bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of Embryological Results of Microinjection in Two Groups of Men with and without Requesting Sperm DNA Fragmentation Index Measurement
Authors: AmirJannati Naser , Mohazzab Arash , Fathalian Manizheh , Akhavizadegan Hamed
Published: January 2024

Introduction. The sperm DNA fragmentation index (DFI) is considered a valuable measure to assess male fertility, but the predictive value of DFI for the outcomes in assisted reproductive technology (ART) is still controversial. Therefore, this study is aimed at investigating the effect of requesting a DFI test or performing ART without DFI on the results observed in the embryology laboratory (number of embryos, fertilization rate, and embryo quality) after intracytoplasmic sperm injection (ICSI). Methods. This retrospective study was conducted on infertile men who underwent ICSI and were referred to the Avicenna Infertility and Recurrent Abortion Treatment Center in Tehran from 2019 to 2022. The samples were categorized into two groups: a case group with DFI measurement and a control group without DFI measurement. We conducted a comparative analysis of the embryology results between the two groups, focusing on parameters such as fertilization rate, number of embryos, and embryo quality. t-tests and Mann–Whitney U tests were used to conduct single variable analysis. Potential confounding effects were adjusted to use the multivariate linear and logistic regression. Results. Data analysis showed no significant statistical difference between the case group and the control group in terms of the number of embryos (95% confidence interval for the regression coefficient β=−0.257‐0.123), and embryo quality (95% confidence interval for β=−0.199‐0.114). There was no significant statistical difference between the two groups due to the fertilization rate (95% confidence interval for β=−3.42‐3.42), except for the variables of woman’s age and sperm count after ICSI, as determined by adjusted linear regression. Conclusions. Although DFI measurement is used to assess male infertility, its importance as a predictor for the embryology outcomes after ICSI requires further evaluation and the determination of a cut-off point for predicting results. This study was based on retrospectively collected DFI data, and prospective studies confirming the superiority of ICSI outcomes are necessary.
Composition-Differentiation Operators on Derivative Hardy Spaces
Authors: Abkar A. , Babaei A.
Published: January 2024

We first explore conditions under which every weighted composition-differentiation operator on the Hardy space H1D is completely continuous. We then discuss necessary and sufficient conditions for these operators to be Hilbert–Schmidt on the derivative Hardy space S2D.
A Review on Bioactive Phytochemical Constituents and Pharmacological Activities of Aegiceras corniculatum: A Pharmaceutically Important Mangrove Plant
Authors: Sarkar Pritam , Ahnaf Tasfiya Rufaidah , Rouf Razina , Shilpi Jamil Ahmad , Uddin Shaikh Jamal
Published: January 2024

Aegiceras corniculatum, commonly referred to as Khalsi, is a member of the mangrove Myrsinaceae family. The various parts of this plant have been used in traditional medicinal systems for their potential therapeutic effects in conditions such as asthma, microbial infections, diabetes, pain relief, inflammation, cancer, and arthritis. A diverse array of bioactive phytochemicals such as flavonoids, benzoquinones, triterpenes, polyphenolic acids, stilbenes, tannins, and macrolides have been identified in different parts of this plant. The aim of this review was to summarize the bioactive phytoconstituents reported from this plant that are accountable for the observed different pharmacological effects of the plant and further elucidate the possible underlying mechanisms by which these chemicals exert their actions. The search was conducted on various widely used database platforms, including Google Scholar, Scopus, Web of Science, SciFinder, and PubMed. Articles published until July 2023 were extracted and all the information was sorted based on the inclusion and exclusion criteria. The data revealed that anti-inflammatory compounds from this plant suppress iNOS, myeloperoxidase, COX, LOX, and cytokines (like TNF-alpha, IL-1ß, LTB4, IL-12, and IL-6) to reduce inflammation. 5-O-Butyl-embelin, 2-hydroxy-5-ethoxy-3-nonyl1, 4-benzoquinone, 5-O-methylembelin, 5-O-methyl-rapanone, s-saponin, and 5-O-ethylembelin are some phytochemicals of A. corniculatum with anticancer properties, although their mechanism is unclear. A. corniculatum has antibacterial, parasitic, and antifungal effects, but no antiviral effects were reported. The plant-isolated coumaric acid and fatty acids interact with bacterial DNA/RNA and limit protein formation, making them antibacterial. Gallocatechin, epicatechin, epigallocatechin-3-O-gallate, epigallocatechin, and other tannins, as well as flavonoids like kaempferol, quercetin, and isorhamnetin, are some of the compounds in A. corniculatum that may depolarize and change bacterial membranes, showing antibacterial effect. These phenolic chemicals also reduce oxidative stress and help treat cancer and other inflammatory diseases. The extract of this plant activates the κ-opioid receptor, causing central antinociception. Catechol components, such as epigallocatechin-3-O-gallate, protect against CNS illnesses including Parkinson’s disease and amnesia. Despite numerous studies demonstrating various pharmacological advantages of this plant and its constituents, the number of clinical trials conducted on humans remains significantly limited.
Defining the Role of Extrachromosomal DNA Amplifications in Medulloblastoma
Authors: Zhao Dacheng , Verhaak Roel G.W.
Published: January 2024

Circular extrachromosomal DNA (ecDNA), a common mechanism of oncogene amplification, has been identified as a major contributor to intratumoral heterogeneity and patient outcomes. In a recent publication in Nature Genetics, Chapman and colleagues further explored the role of ecDNA in the context of medulloblastoma. Using whole-genome sequencing, they found that 18% of the patients carry ecDNA amplification across a 468 medulloblastoma patient cohort. The presence of ecDNA was associated with worse survival. Single-cell FISH imaging and multiomic sequencing revealed that ecDNA copy number displayed a cell-to-cell variability within the sample, contributing to tumor heterogeneity. Furthermore, through sequencing and CRISPRi experiments, the authors uncovered frequent enhancer rewiring events on ecDNA that drive proliferation.
Supplementary Table 3 from Early-onset Colon Cancer Shows a Distinct Intestinal Microbiome and a Host–Microbe Interaction
Authors: Adnan Darbaz , Trinh Jonathan Q. , Sharma Deepak , Alsayid Muhammad , Bishehsari Faraz
Published: January 2024

Supplementary Table 3: Correlations between microbial abundance and activity of host KEGG pathways in early- versus late-onset CRC.
Supplemental Figure 2 from Intracellular K+ Limits T-cell Exhaustion and Preserves Antitumor Function
Authors: Collier Camille , Wucherer Kelly , McWhorter Matthew , Jenkins Chelsea , Bartlett Alexandra , Roychoudhuri Rahul , Eil Robert
Published: January 2024

Supplemental Figure 2. NAC constrains the function of wild-type and Atp1a1 deficient CD8 T cells
Supplementary Table 2 from A Randomized Phase III Study of Arfolitixorin versus Leucovorin with 5-Fluorouracil, Oxaliplatin, and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer: The AGENT Trial
Authors: Tabernero Josep , Yoshino Takayuki , Stintzing Sebastian , de Gramont Aimery , Gibbs Peter , Jonker Derek J. , Nygren Peter , Papadimitriou Christos , Prager Gerald W. , Tell Roger , Lenz Heinz-Josef
Published: January 2024

Supplementary Table 2. Investigated Genes and Functions of the Corresponding Relevant Proteins
Supplementary Table 11 from A Randomized Phase III Study of Arfolitixorin versus Leucovorin with 5-Fluorouracil, Oxaliplatin, and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer: The AGENT Trial
Authors: Tabernero Josep , Yoshino Takayuki , Stintzing Sebastian , de Gramont Aimery , Gibbs Peter , Jonker Derek J. , Nygren Peter , Papadimitriou Christos , Prager Gerald W. , Tell Roger , Lenz Heinz-Josef
Published: January 2024

Supplementary Table 11. Serious Adverse Events
Supplementary Table 10 from A Randomized Phase III Study of Arfolitixorin versus Leucovorin with 5-Fluorouracil, Oxaliplatin, and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer: The AGENT Trial
Authors: Tabernero Josep , Yoshino Takayuki , Stintzing Sebastian , de Gramont Aimery , Gibbs Peter , Jonker Derek J. , Nygren Peter , Papadimitriou Christos , Prager Gerald W. , Tell Roger , Lenz Heinz-Josef
Published: January 2024

Supplementary Table 10. Summary of Adverse Events
Supplementary Table 1 from A Randomized Phase III Study of Arfolitixorin versus Leucovorin with 5-Fluorouracil, Oxaliplatin, and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer: The AGENT Trial
Authors: Tabernero Josep , Yoshino Takayuki , Stintzing Sebastian , de Gramont Aimery , Gibbs Peter , Jonker Derek J. , Nygren Peter , Papadimitriou Christos , Prager Gerald W. , Tell Roger , Lenz Heinz-Josef
Published: January 2024

Supplementary Table 1. Detailed Inclusion and Exclusion criteria
Supplementary Figure 6 from A Randomized Phase III Study of Arfolitixorin versus Leucovorin with 5-Fluorouracil, Oxaliplatin, and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer: The AGENT Trial
Authors: Tabernero Josep , Yoshino Takayuki , Stintzing Sebastian , de Gramont Aimery , Gibbs Peter , Jonker Derek J. , Nygren Peter , Papadimitriou Christos , Prager Gerald W. , Tell Roger , Lenz Heinz-Josef
Published: January 2024

Association between ERCC1 Expression and Progression-Free Survival (biomarker analysis set)
A Case of Immune-Related Aseptic Meningitis during Atezolizumab plus Bevacizumab for Hepatocellular Carcinoma
Authors: Kawanaka Hiroki , Tajiri Kazuto , Muraishi Nozomu , Murayama Aiko , Nukui Takamasa , Yasuda Ichiro
Published: January 2024

Introduction: Immune checkpoint inhibitors are sometimes associated with immune-related adverse events during or after treatment. Among these, aseptic meningitis is a rare and serious complication. We report the first case of atezolizumab-induced aseptic meningitis, which occurred during treatment for advanced hepatocellular carcinoma (HCC). Case Presentation: A 74-year-old woman diagnosed with advanced HCC and treated with first-line atezolizumab plus bevacizumab developed anorexia, fatigue, and fever, after three treatment cycles. Cerebrospinal fluid examination showed slightly increased cell count and protein level but no infection or malignancy. Contrast enhancement along the cerebral sulcus was evident in contrast-enhanced magnetic resonance imaging, and the patient was diagnosed with aseptic meningitis associated with atezolizumab. Steroid therapy soon improved her clinical symptoms, and the contrast enhancement along the cerebral sulcus disappeared. Conclusion: Clinicians should monitor to avoid serious immune-related adverse events, such as aseptic meningitis, in patients during treatment of HCC with immune checkpoint inhibitors and make the diagnosis as soon as possible.
In vitro Evaluation of DINCH-Plasticized Blood Bags for Red Blood Cell Storage with CPDA-1 Anticoagulant
Authors: Kim Hyungsuk , Lee Kyunghoon , Seo Soo Hyun , Hong Yun Ji , Hwang Sang Mee , Park Jeong Su , Park Kyoung Un , Song Junghan
Published: January 2024

Introduction: Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer commonly used in blood bags. Despite its protective effects on red blood cell (RBC) storage, concerns about its reproductive toxicity exist. This study investigated the in vitro quality of RBC concentrates stored in bags using di(isononyl) cyclohexane-1,2-dicarboxylate (DINCH) as an alternative plasticizer. Methods: Using a pool-and-split study design, we produced 20 matched homogenous quintets of RBC concentrates in two DINCH bags and three DEHP bags with citrate phosphate dextrose adenine (CPDA-1) anticoagulant. RBC storage quality was assessed weekly for 35 days. Results: On day 35, the median hemolysis levels in the DINCH bags (0.297–0.342%) were marginally higher (p < 0.05) than the DEHP bags (0.204–0.240%). All DINCH bags showed <0.8% hemolysis. RBCs in the DINCH bags showed increased mean corpuscular volume and decreased eosin 5′ maleimide binding than in the DEHP bags. Higher pO2 and lower pCO2 levels in the DINCH bags indicated better gas permeability than in DEHP bags. Other metabolic parameters were comparable in both bags. Compared to DEHP, DINCH exhibited considerably lower levels of plasticizer leaching into blood bags. Conclusion: The quality of RBC concentrates stored for 35 days in DINCH-plasticized blood bags with CDPA-1 is generally comparable to those in DEHP bags. Hence, DINCH can be a viable alternative to DEHP in blood bags for nonleukoreduced RBC storage even without the use of next-generation additive solutions to improve RBC preservation quality.
Trockenes Auge bei Typ-2-Diabetikern: GLP-1-Agonisten scheinen einen protektiven Effekt zu haben
Authors: Bachmann Björn
Published: January 2024

The glucagon-like peptide 1 (GLP-1) agonist showed anti-hyperglycemic and anti-inflammatory effects, which may retard the risk of external eye disease. The protective effect of GLP-1 agonist and dry eye disease (DED) was found, while the relationship between GLP-1 agonist and other corneal diseases was not clear. Herein, we aim to evaluate the association between the usage of GLP-1 agonists and the development of the following external eye disease in type 2 diabetes mellitus (T2DM) patients. A retrospective cohort study using the National Health Insurance Research Database (NHIRD) of Taiwan was conducted. The T2DM patients were divided into those with GLP-1 treatment and those without GLP-1 treatment and matched with a 1:2 ratio. The main outcomes were the development of dry eye disease (DED), superficial keratitis, and infectious keratitis. The Cox proportional hazard regression was adopted to produce the adjusted hazard ratio (aHR) with a 95% confidence interval (CI) of external eye diseases between groups. There were 115, 54, and 11 episodes of DED, superficial keratitis, and infectious keratitis in the GLP-1 group. Another 280, 168, and 31 events of DED, superficial keratitis, and infectious keratitis were recorded in the control group. The GLP-1 group demonstrated a significantly lower incidence of DED (aHR: 0.853, 95% CI: 0.668–0.989, p = 0.0356) and superficial keratitis (aHR: 0.670, 95% CI: 0.475–0.945, p = 0.0107) compared to the control group. In the subgroup analyses, the correlation of GLP-1 agonist and DED development was more prominent in patients younger than 60 years old (p = 0.0018). In conclusion, the GLP-1 agonist treatments are significantly associated with a lower incidence of subsequent DED and superficial keratitis, while the relationship was not significant between GLP-1 agonist usage and infectious keratitis.
A independência do Brasil na fronteira meridional: uma análise do projeto de defesa da província de Santa Catarina, 1822
Authors: Schmitt Ânderson Marcelo
Published: January 2024

This article analyzes the content of the defense project for the province of Santa Catarina, written on November 16, 1822 by the Commander of Arms of this province, the engineer Aureliano de Souza e Oliveira. By doing so, the strict content itself was extrapolated, and it was possible to understand the military, territorial and political dynamics in which this project was created, so being able to observe its ways of implementation and limitations. Thus, this article aims to understand, from a specific case, the context of the southern border during the most critical moments of the military dispute that, although not generalized, marked the rupture between the two sides of the United Kingdom of Portugal, Brazil and Algarves. In the end, it is concluded that the effective defense responded to conjunctural imperatives and was limited to needs for which the province did not have an immediate solution.
OPW and de Ste. Croix: the Past and Present Views of a Pupil
Authors: Lane Fox Robin
Published: January 2024

This survey, by a pupil of Geoffrey de Ste. Croix and eventual successor in his Oxford job, combines personal recollections of de Ste. Croix’s horizons and intellectual range with a penetrating study of his Origins of the Peloponnesian War, its underlying debts and detailed contentions. It addresses his, and Thucydides’, engagement with origins and causes, his central contention about votes by the Spartans and their allies on whether to go to war, the roles of Corinth, Megara and the much-discussed Megarian decree. It also presents a close reading of an Athenian involvement in Macedon and the north and its relevance to de Ste. Croix’s views on Athenian imperialism. It then sets the book’s conclusions in a wider context, ranging from modern writings on the origins of war to its concluding echo of Lenin.
Ivo Andrić: Bosnian and Serbian Nationalism (Book review: Zoran Milutinović, Bitka za prošlost. Ivo Andrić i bošnjački nacionalizam, Beograd: Geopoetika, 2018. 384 pp. ISBN: 978–86–6145–296–3 & Zoran Milutinović, Fantom u biblioteci. Postoji li srpski nacionalistički diskurs o Ivi Andriću?, Beograd: Geopoetika, 2022. 256 pp. ISBN: 978–86–6145–388–5)
Authors: Száz Pavol
Published: January 2024

The double review deals with two books by Zoran Milutinović. Bitka za prošlost [The Battle for the Past] (2018) explores the Bosnian nationalist reception of Ivo Andrić in the form of an in-depth discourse analysis. Milutinović points out the biases of this discourse, the unsoundness of its arguments and the unprofessionalism of its reading. Notable among the reactions to the book was a study by Nenad Veličković, in which he argued that the Bosnian nationalist reception was merely a reaction to Andrić’s Serbian nationalist reception. Milutinović has devoted his book Fantom u biblioteci [Phantom in the Library] (2022) to a thorough examination of this claim, in which he takes stock of the critical reception and points out its unfoundedness.
Cultural Policy of the Democratic Republic of Georgia (1918–1921)
Authors: Shatberashvili Vazha
Published: January 2024

Culture, cultural heritage is a kind of text allowing us to “read” about the identity and genetic code of a nation, or, in other words, providing a key to understanding the “personality” and mindset of the nation and, at the same time, creating a path to the future. Therefore, protecting and developing culture to ensure cultural continuity is an essential prerequisite for ensuring the existence and progress of each nation and country – this is the firmly held axiom on which the cultural policy of states is based. This becomes all the more relevant for Georgia, which, due to its unique location and geopolitical, cultural and strategic importance, already in the distant past embraced the cultural achievements of the eastern and western civilisations and succeeded in creating its uniquely distinct and diverse national culture, thus putting itself firmly on the map of world culture. Of utmost importance in this process is the brief transitional period of existence of the Democratic Republic of Georgia (1918–1921), during which the country actively set about defining and implementing state cultural policy and establishing a national administration system in this sphere. The article argues that the state vision of culture or, in modern terms, cultural policy corresponding to the political system then in place, existed within the aforesaid time frame long before the world, including modern Georgia, saw the need to develop a cultural policy. Considering the country’s legislative framework, the institutional administration system of the cultural sphere, the dynamics of cultural life and its peculiarities, and internationally recognised concepts and models, we tentatively define the cultural policy model of the Democratic Republic of Georgia in the last part of the article. We liken it, to a certain extent, to the Architect State model as developed by Harry Hillman Chartrand and Claire McCaughey. The bureaucratic-educational concept model offered by Milena Dragićević-Šešić and Branimir Stoykovich also proved to be of interest. The international models put forward by the aforesaid scholars undoubtedly differ from the historically existing ktitoric/protective model of Georgian culture, as well as from the protective model established by the Democratic Republic of Georgia. There are, however, some common features between them: centralised patronage/support of culture by the state, non-intervention in the content of art; considering culture and art as one of the precursors to the social wellbeing of society; highlighting the priority importance of the educational function of culture and art. With due regard for the foregoing, we have tentatively designated the cultural policy model applied by the Democratic Republic of Georgia as the educational model of the Architect State.
Lettre de Ladislas Mickiewicz. List Władysława Mickiewicza. Letter of Władysław Mickiewicz
Authors: Sajkowski Wojciech
Published: January 2024

The text is a transcription and translation into Polish and English of a French-language letter from Wladysław Mickiewicz (1838–1926), son of the great poet, Adam Mickiewicz (1798–1855), to the Bulgarian poet, modernist associated with the group “Thought” and the magazine Mis'l [Thought] (1892–1907).
Wavelength-Dependent Nonlinear Optical Activities of Near-Infrared Boron-Dipyrromethene Derivatives
Authors: Ren Can , Hu Ju-Guang
Published: January 2024

Near-infrared (NIR) organic dyes with strong ultrafast nonlinear optical (NLO) activities are important for various applications. However, the study of the wavelength-dependent NLO properties of NIR dyes is still ongoing. In this work, we present the first comparison of the NLO properties
of two NIR boron-dipyrromethene (BODIPY) derivatives at different excitation wavelengths, in which strong electron-donating groups, namely 4-(N,N-dimethylamino)phenyl and 1-ethyl-1,2,3,4-tetrahydroquinoline groups, are connected through the BODIPY cores. Results obtained from Z-scan
experiments show that the two BODIPY derivatives exhibit strong saturable absorption and large modulation depth when excited by femtosecond pulses at 800 nm. With 1300 nm excitation, both derivatives exhibit strong nonlinear refraction. In addition, the derivatives also display effective two-photon
action cross-sections in the wavelength range of 1200–1600 nm. They are potentially excellent nonlinear optical materials. This comprehensive comparison of the NLO properties of BODIPY derivatives can suggest new possibilities for the design and development of NIR NLO materials.
Analysis of Cargo Sorting Robot Based on Multiple Photoelectric Sensors
Authors: Xue Yuxia , Li Junhong , Liu Jiaxin , Yang Jie , Li An
Published: January 2024

With the rise of e-commerce, dangerous goods such as flammable and explosives carried in logistics goods have a negative impact on the development of the logistics industry and seriously threaten staff safety. Infrared is widely used in the logistics cargo security inspection system,
which can detect the goods’ shape and internal temperature and analyze the type of goods through spectra. These characteristics help to determine whether it is a hazardous material. In this research, a photoelectric intelligent sorting robot based on an infrared sensor and a Charge Coupled
Device (CCD) sensor is designed. The robot’s hardware system is first developed, and then its important components’ model selection is made. The cargo loading module is designed according to the size of the cargo to be sorted. The cargo information collection module comprises multi-infrared
sensors and CCD sensors, and the robot’s hardware is logically connected. In the sorting process, the cargo information is required for model training, the SSD_inception network model is used for training, and the Sort_target data structure is defined to label different cargo information.
In the test, the design-based robot, with the increase of measurement distance, the relative distance error of detecting cargo shows an increasing trend, but the error is within 5%. The cargo ID can be determined through the information received by multiple photoelectric level sensors, and
they are placed in the designated area, thus successfully achieving the sorting of cargo.
Influence of Oxa-Nano-Liposome on the Drug Resistance of Gastric Cancer Cells Under p53-Mediated Autophagy
Authors: Sun Zicheng , Chen Haijun , Liu Yan
Published: January 2024

The influence of oxaliplatin (Oxa)-nano-liposomes on the drug resistance of gastric cancer cells (GCCs) and the role of p53-mediated autophagy in this process were investigated in this research. Oxa-nano-liposomes were prepared and their quality was evaluated. GCCs treated with Oxa-nano-liposomes
were selected and rolled into a negative control (NC) group (cells+ culture medium), a positive control (PC) group (standard Oxa-nano-liposome), and a Oxa-nano-liposome sample group. Cell inhibition rates (IRs) at changeable drug concentrations (DCs) were compared and analyzed. Furthermore,
levels of p53 and autophagy-related proteins (ARPs) (such as LC3-II and p62) in the cells were assessed using Western blotting. The results indicated that Oxa-nano-liposomes prepared (Oxa):natural soy phospholipids (NSP):cholesterol:polyethylene glycol (PEG) 2000 = 1:2:1:1 exhibited the best
performance. The Oxa-nano-liposome sample group exhibited a higher cell IR to the NC group, showing a great difference (P <0.05). Additionally, the Oxa-nano-liposome sample group demonstrated superior efficacy compared to the PC group. With increasing DC, p53 and LC3-II were upshifted,
while p62 was downshifted. In conclusion, Oxa-nano-liposomes effectively inhibited the growth of GCCs, exhibited improved efficacy, and contributed to reducing drug resistance in GCCs towards Oxa-nano-liposomes. Therefore, the Oxa-nano-Liposomes hold significant potential for clinical application.
Moreover, p53 regulated the cellular autophagy, enhancing autophagic activity of GCCs.
Synergizing Material Chemistry and Biomechanics for Enhanced Sports Equipment: Optimization of Carbon Nanotubes/Mg Nanocomposites
Authors: Li Bo , Jing Huaiguo
Published: January 2024

The production of sports equipment necessitates a delicate balance between comfort, performance, and safety. Achieving this equilibrium depends on a profound understanding of material chemistry and the biomechanical considerations that come into play as athletes push their bodies to
the limits. In recent years, composite materials have gained substantial attention for their impressive mechanical and physical properties. Among these, carbon nanotube (CNT) reinforced magnesium matrix composites (MMCs) have emerged as promising contenders. These materials are synthesized
using powder metallurgy and hot extrusion techniques, capitalizing on CNTs’ unique properties to enhance the mechanical characteristics of magnesium-based materials. This study delves into the parametric optimization of CNT-reinforced MMCs, particularly focusing on microstructure design.
Leveraging a homogenization-based optimization system, we investigate both material properties and shape optimization. Finite element numerical simulations validate our predictions, showcasing significant improvements in various parameters, most notably alterations in fiber layup angles, which
contribute to enhanced performance characteristics. This approach serves as an invaluable tool for streamlining composite structure design while simultaneously reducing the costs associated with traditional experimental methods. By harnessing the potential of CNT-reinforced MMCs and optimization
techniques, this research advances sports equipment design, ultimately ensuring athletes’ safety and the optimization of their performance.
Estimating Tiotropium Wasted Doses After Adding Revefenacin to an Inpatient Formulary: A Single-Center Cross-Sectional Study
Authors: Boylan Paul M. , Fuller Jordan A. , Guidry Corey M. , Neely Stephen
Published: January 2024

Introduction: Revefenacin is a once-daily nebulized long-acting muscarinic antagonist (LAMA). Revefenacin is supplied as single-use nebulized vials, which may be preferable and less costly for hospital and health-system pharmacies to dispense versus multidose tiotropium inhalers. Estimates of LAMA multidose inhaler wasted doses remains unknown. Methods: This was a single-center descriptive cross-sectional study conducted between January 1 2021 and December 31 2021. Adult patients 18 years and older admitted to a 500-bed academic medical center in the southern United States and were ordered multidose tiotropium packages or single-use revefenacin vials during the study period were included. Results: Among 602 inpatients, there were 705 LAMA orders: 541 tiotropium (76.7%) and 164 revefenacin (23.3%). Four hundred ninety-five tiotropium orders (91.5%) wasted between 20% and 90% of multidose packages. Approximately $24,000 tiotropium doses were wasted versus single-use revefenacin vials. Conclusion: Multidose inhalers of tiotropium dispensed to hospitalized patients contributed to wasted doses compared to nebulized single-use revefenacin vials. Opportunities exist to minimize wasted doses of multidose long-acting inhalers dispensed to hospitalized patients.
Long-Term Performance of Soybean-Based Concrete Surface Protectant under Laboratory Accelerated Aging Conditions
Authors: Houshmand Khaneghahi Mohammad , Mutua Angela , He Jialuo , Mishra Geetika , (Amir) Farnam Yaghoob
Published: January 2024

Soy methyl ester-polystyrene (SME-PS) is an organic material derived from soybeans, which has proven to be an effective protectant for concrete surfaces. This study investigated the long-term performance of cement paste samples treated with SME-PS under laboratory accelerated aging conditions (AAC). The specimens were subjected to cyclic conditions: 8 h of UVA radiation (simulating solar radiation), followed by 6 h of darkness with water condensation and a high temperature of 40°C for 28 days. After the AAC exposure, the samples were immersed in a deicing salt solution, specifically a 29.8 wt. % calcium chloride solution, for 7 days. To evaluate the long-term behavior of SME-PS, a series of experiments, including visual observation, thermogravimetric analysis (TGA), and low-temperature differential scanning calorimetry (LT-DSC) was conducted. Visual observations revealed slight damage in SME-PS-treated samples after AAC exposure, while control samples experienced microcrack formations. SME-PS chemical compositions remained unaffected by AAC, in contrast to the control samples where a decrease in the quantity of calcium hydroxide and an increase in calcium carbonate content were observed as a result of carbonation during AAC exposure. LT-DSC results indicated that SME-PS-treated samples showed a significant reduction in the enthalpy of fusion associated with calcium oxychloride (CAOXY) formation, indicating that the SME-PS remained effective after AAC exposure, while control samples exhibited higher CAOXY enthalpy of fusion.
Robot-assisted partial nephrectomy using the novel Hugo™ RAS system: Feasibility, setting and perioperative outcomes of the first off-clamp series
Authors: Prata F , Ragusa A , Civitella A , Tuzzolo P , Tedesco F , Cacciatore L , Iannuzzi A , Callè P , Raso G , Fantozzi M , Pira M , Ricci M , Pino M , Minore A , Basile S , Testa A , Crimi VG , Deanesi N , Travino A , D’Addurno G , Scarpa RM , Papalia R
Published: January 2024

Introduction:

Hugo Robot-Assisted Surgery (RAS) System has been conceived with enhanced modularity but its role for nephron-sparing surgery setting still remains poorly explored. We aimed to describe our experience in robot-assisted partial nephrectomy (RAPN) with a three-arms setting for the first off-clamp series using the new Hugo RAS System.

Methods:

Patients were placed on an extended flank position at the margin of the surgical bed with a slightly flexion (45°). The first 11 mm robotic trocar (camera port) was placed along the pararectal line 14 ± 2 cm far from the umbilicus. The pneumoperitoneum was then induced through the AirSeal system (SurgiQuest, Milford, Connecticut, USA©). Two more 8 mm operative robotic ports were placed under direct vision, either 8 ± 1 cm far from optic’s port. Two 12 mm laparoscopic ports for bed-assistant were placed between robotic ports. Monopolar curved shears, fenestrated grasper, and large needle driver were used in a three-instruments configuration.

Results:

Off-clamp RAPN was successfully performed in seven patients with cT1 renal masses using a trans-peritoneal route. Median port placement and docking time was 6 min (IQR, 4–8 min). Hemostasis was achieved through renorraphy using a single transfix stitch with sliding clips technique. There was no need for additional ports placement. No intraoperative complications occurred, no clashing of robotic instruments or between the robotic arms was observed. No technical failures of the system occurred. Median console time was 83 min (IQR, 68–115 min). Median estimated blood loss were 200 ml (IQR, 50–400 ml). All patients were discharged between post-operative day 2 and 3, without the need of hospital readmission. No complications were recorded within the first 30 post-operative days.

Conclusions:

We performed the first series of off-clamp RAPN using the novel HUGO RAS System. This novel robotic platform showed an easy-friendly docking system, providing excellent perioperative outcomes with a simple three-arms configuration.
Religious Involvement and the Impact on Living Alone and Depression: An Examination of Gendered Pathways Post-Widowhood
Authors: Hawes Frances M. , Tavares Jane L.
Published: January 2024

This study analyzed data from the nationally representative Health and Retirement Study (HRS) to examine the association between widowhood and depression. The results revealed that both men and women experienced increased depression after widowhood, with women exhibiting a better recovery pattern over time. Religiosity, especially attending religious services, was found to be a beneficial coping mechanism for both genders, although men were less religious than women. Living alone was a significant factor associated with depression in widowhood for both men and women. High religious service attendance moderated the association between living alone and depression for women, while both high and moderate religious service attendance moderated this association for men. These findings emphasize the importance of considering gender differences and the potential benefits of religious involvement in addressing depression during widowhood, highlighting the need for tailored interventions and support services for widows and widowers, particularly those living alone.
Estimation of road adhesion coefficient and sideslip angle for electric vehicles with slip-aware constraints using strong tracking unscented Kalman filter
Authors: Wang Lei , Pang Hui , Zuo Ruxuan , Zheng Lizhe , Hu Chuan
Published: January 2024

Accurate estimation of road adhesion coefficient and sideslip angle are crucial for safer driving and ride quality of electric vehicles (EVs). To that end, an estimation algorithm of road adhesion coefficient and sideslip angle for EVs with slip-aware constraints and strong tracking unscented Kalman filter (SSTUKF) algorithm is designed in this paper. First, a vehicle system model is established as the basis for deriving the desirable estimation algorithm. Then, a strong tracking unscented Kalman filter (STUKF) algorithm with fading factor is presented to strengthen the correction effect of error covariance matrix used in unscented Kalman filter (UKF) algorithm. Meanwhile, slip-aware constraints are considered to calculate the adaptive compensated steering angle, which is obtained by repeated iteration of the fitness function. Additionally, a data fusion estimator is established based on the extremum theory to solve the problem of inaccurate estimation of sideslip angle under complex driving conditions. Finally, the CarSim-MATLAB/Simulink simulation platform is used to simulate under different driving conditions, and the simulation results reveal that the presented SSTUKF algorithm can enhance the estimation performance.
Cognitive and Neurodiversity in Groups: A Systemic and Integrative Review
Authors: van Rijswijk Jan , Curșeu Petru Lucian , van Oortmerssen Lise A.
Published: January 2024

This paper reviews the literature on cognitive and neurodiversity in groups as they relate to group processes, emergent states, and outcomes. We build on a taxonomy of convergent and divergent process gains and losses in groups, put forward an integrative framework for the empirical research results, and distinguish between cognitive and neurodiversity as horizontal and vertical differentiation in groups. We argue that when conceptualized as vertical differentiation, cognitive and neurodiversity trigger convergent and divergent process losses, whereas when conceptualized as horizontal differentiation, they chiefly trigger convergent and divergent process gains. Building on this framework, we identify directions for future research on cognitive and neurodiversity in groups.
Clinicopathological, Immunohistochemical, and Molecular Characteristics of Pigmented Microcystic Chromophobe Renal Cell Carcinoma with Favorable Prognosis
Authors: Guo Xingmei , Xiao Zhini , Xu Haimin , Ren Kai , Li Xiangyun , Wu Yuan Kai , Liu Yang , Zhou Luting , Wang Lei , Liu Hengan , Dong Lei , Dong Hui , Yang Xiaoqun
Published: January 2024

Background. Pigmented microcystic chromophobe renal cell carcinoma (RCC) is a subtype of chromophobe RCC. Its distinct histopathologic features are microcystic and microtubular pattern, pigmentation, and microcalcifications. Pigmented microcystic chromophobe RCC has ultrastructure, immunophenotypic structure, and molecular results similar to chromophobe RCC. Methods. We report five tumors of pigmented microcystic chromophobe RCC. Morphological observation and immunohistochemical examination were performed, and clinical and molecular features were analyzed. Results. Microscopically, all five tumors showed brown pigmentation, microcystic, and tubular cystic structures, one tumor presented microscopic calcifications. All tumors were positive for EMA, AE1/AE3, PAX8, KRT7, KIT (CD117), claudin 7, KRT8, and E-cadherin, and three tumors expressed P504S. All tumors were negative for vimentin, CA9, KRT20, TFE3, TFEB, Melan-A, HMB45, FH, SDHB, and GATA3. Ki-67 index varied from less than 1% to 2%. In three tumors, next-generation sequencing of the 688 gene was performed, the results found gene variants with potential clinical significance such as JMJD1C, MYCL, TP53, PI3KCA, KRAS, APC, GLI1, LRRK2, and gene variants with unclear clinical significance such as NTRK1 and RAD50; All patients remained alive over a follow-up period of 8–46 months without tumor recurrence and sarcomatoid transformation. Conclusions. Pigmented microcystic chromophobe RCC has a relatively benign biological behavior, and distant metastases and sarcomatoid transformation are rare. This overview of five additional tumors of pigmented microcystic chromophobe RCC offers further insight into this special subtype of chromophobe RCC.
Treatment Patterns and Healthcare Resource Utilization of Patients With Paroxysmal Nocturnal Hemoglobinuria: A Retrospective Claims Data Analysis
Authors: Clayton Denise , Shafrin Jason , Yen Glorian , Lee Soyon , Geevarghese Lincy , Shi Yulin , He Luyang , Shen Ying , Waheed Anem
Published: January 2024

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired hematologic disorder commonly treated with complement inhibitors such as eculizumab, ravulizumab, and pegcetacoplan. This study aims to describe treatment patterns, healthcare resource utilization, and cost for newly diagnosed PNH patients in 2 large, health insurance claims databases: MarketScan and Optum. Among the 271 patients meeting the inclusion criteria in MarketScan, 57.9% were female, and the average age was 46.6 years. Among these newly diagnosed patients, 25.1% ( n = 68) of patients received a PNH-specific pharmacologic treatment, and the average time from diagnosis to treatment was 4.7 months. The medication possession ratio was 97.0%, but discontinuation was common (58.8%). The average per-patient-per-month costs were $18,978, driven by pharmacy and infusion ($11,182), outpatient ($4086), and inpatient ($3318) costs. Despite the availability of multiple treatments, 39.9% of patients had an inpatient stay, and 50.9% had an emergency department visit. Better care management and the introduction of new treatment options are needed to address delays between diagnosis and treatment, and high rates of hospitalization and emergency department use among patients with PNH.
Political knowledge of youth and their proneness to prejudice: Empirical test of direct and indirect effect via right-wing authoritarianism
Authors: Matić Bojić Jelena , Bovan Kosta
Published: January 2024

In this paper, we explored how political knowledge related to generalised prejudice, defined as the common variance of three highly correlated specific prejudice concerning ethnicity, gender and sexual orientation. We aligned our hypotheses with the Cognitive Ability and Style to Evaluation (CASE) model, which postulates the mechanism underlying the relationship between individual-level cognitive variables and intergroup outcomes. As knowledge in its many forms correlates with and serves as a proxy of cognitive abilities, we hypothesised that political knowledge, when considered a precursor of prejudice, can be expected to act similarly to cognitive variables within the CASE model. We performed an empirical test of the hypothesised relationships on a nationally representative sample of Croatian students in their final year of secondary education (aged 17–19). As expected, there was a significant negative association between political knowledge and generalised prejudice, both direct and indirect via right-wing authoritarianism. Youth with higher political knowledge had significantly lower levels of generalised prejudice. In addition, while there were differences in the overall levels of political knowledge, right-wing authoritarianism and generalised prejudice between students attending different secondary education programmes, the pattern of relationships between these concepts was found to be stable across educational settings.
Factions and the Redistributive Effects of Reform in Japan
Authors: Carlson Matthew M , Nakabayashi Masaki
Published: January 2024

Campaign finance and other political reforms often have redistributive consequences when they improve the position of one group over another. When potentially redistributive reforms are debated or passed, groups may resist or support such reforms depending on their belief about whether the reforms will be advantageous or not to their own position. In dominant party systems such as Japan, we expect that major reforms will have heterogeneous effects for different factions within Japan’s Liberal Democratic Party (LDP). In 1975 and 1994, reformers in Japan introduced major changes that they hoped would reduce corruption and strengthen political parties over factions. In this article, we empirically investigate the asymmetrical impact of the reforms on the total amount of revenue and contributions disclosed by factions in the LDP. We find that the 1975 reform had significant redistributive effects, including a relatively adverse impact on the faction linked to Tanaka Kakuei in terms of total revenue. The 1994 reforms, in contrast, reveal that the Tanaka faction did the best among the factions in collecting revenues and consolidating its power.
Parents’ and Caregivers’ Support for in-School COVID-19 Mitigation Strategies: A Socioecological Perspective
Authors: Prichett Laura , Berry Andrea A. , Calderon Gabriela , Wang June , Hager Erin R. , Klein Lauren M. , Edwards Lorece V. , Liu Yisi , Johnson Sara B.
Published: January 2024

Informed by the social ecological model, which asserts that health behaviors and beliefs are the result of multiple levels of influence, we examined factors related to parents’ support for in-school COVID-19 mitigation strategies. Using data from a survey of 567 parents/caregivers of public elementary and middle school students in eight Maryland counties, we employed regression models to examine relationships between parent-, child-, family-, school-, and community-level factors and acceptability of mitigation strategies. Acceptance of COVID-19 mitigation strategies was positively correlated with child- and family-level factors, including child racial identity (parents of Black children were more accepting than those of White children, odds ratio [ OR]: 2.5, 95% confidence interval [CI] = [1.5, 4.1]), parent receipt of the COVID-19 vaccine ( OR: 2.4, 95% CI = [1.5, 3.7]), and parent Democrat or Independent political affiliation (compared with Republican affiliation, OR: 4.2, 95% CI = [2.6, 6.7]; OR: 2.2, 95%CI = [1.3, 3.8], respectively). Acceptance was also positively associated with parents’ perceptions of their school’s mitigation approach, including higher school mitigation score, indicating more intensive mitigation policies ( OR: 1.1, 95% CI = [1.0, 1.1]), better school communication about COVID-19 ( OR: 1.7, 95% CI = [1.4, 1.9]) and better school capacity to address COVID-19 ( OR: 1.9, 95% CI = [1.5, 2.4]). Community-level factors were not associated with acceptance. Child- and parent-level factors identified suggest potential groups for messaging regarding mitigation strategies. School-level factors may play an important role in parents’ acceptance of in-school mitigation strategies. Schools’ capacity to address public health threats may offer an underappreciated and modifiable setting for disseminating and reinforcing public health guidance.
Periprocedural thromboembolic complications of LEO baby stent in endovascular treatment of intracranial aneurysms: Experience in 149 patients
Authors: Shen Yunan , Ni Heng , Jia Zhenyu , Cao Yuezhou , Lu Guangdong , Liu Xinglong , Wang Bin , Zhou Chun , Shi Haibin , Liu Sheng , Zhao Linbo
Published: January 2024

Objective

To report periprocedural thromboembolic complications of LEO Baby stent-assisted coiling of wide-necked intracranial aneurysms and to analyze the possible influencing factors.

Methods

We retrospectively identified 149 patients with aneurysms who underwent LEO Baby stent-assisted embolization between October 2018 and March 2022. Clinical and radiographic data of patients were reviewed to determine whether a thromboembolic event had occurred. Multivariate logistic analysis was performed to identify significant factors associated with thromboembolic events.

Results

Successful stent deployment of the stent was achieved in all patients in the target artery. There were 66 patients (44.3%) with acutely ruptured aneurysms and 83 patients (55.7%) with unruptured aneurysms. Fourteen (9.4%, 95% confidence interval: 4.7%–14.1%) patients were confirmed to have developed a thromboembolic event, including nine patients with acute intraoperative thrombosis and five patients with postoperative thromboembolic events. The rate of thromboembolic events was 6.0% (5/83) in patients with unruptured aneurysms and 13.6% (9/66) in patients with acutely ruptured aneurysms. There was a trend toward an increased rate of thromboembolic events in patients with acute ruptured aneurysms ( p = 0.087). Thromboembolic events were significantly associated with the parent-artery diameter ( p = 0.010).

Conclusions

Our study demonstrates a low rate of thromboembolic complications in unruptured aneurysms treated with LEO Baby stent. Thromboembolic events appear to be more common in ruptured aneurysms. A small diameter of the parent artery is associated with an increased risk of thromboembolic complications, and more relevant studies are still needed.