bluuebunny/crossref_metadata_2025 huggingface dataset:
Isopropyl Lactate Obtaining by Esterification in a Reactive Distillation System
Authors: Taga (Sapunaru) Olga Valerica , Koncsag Claudia Irina , Mares Alina Monica , Jinescu Gheorghita
Published: February 2020

The reactive distillation is a way for the intensification of chemical processes by thermal integration into a single process of chemical reactions with products separation. Isopropyl lactate is an important intermediate for drug synthesis what can be synthesized through reactive distillation. Based on scientific studies in literature, a preliminary study was performed in a reactive distillation laboratory system, in order to obtain isopropyl lactate by esterification of lactic acid with isopropyl alcohol. The independent variables studied are: the alcohol/lactic acid molar ratio (R), the catalyst concentration (CA) and the number of theoretical trays in the fractionation zone (NTT). The experimental matrix was established for a 23 factorial experiment, by considering two levels for each variable: R=1 and 3 mole/mole; CA= 3 %wt and 5 %wt; NTT=1.9 and 2.9. A linear mathematical model was proposed to correlate the lactic acid conversion with the molar ratio of reactants, catalyst concentration and the number of theoretical plates in the column. The model shows that R and NTT are the important variables of the process while the acid concentration is less important, in the studied range. The correlation coefficient is R2=0.9978 and the statistical analysis ANOVA of the model�s coefficients proved they are significant at a confidence level of 95%, so the model is reliable.
Spectroscopic, Textural and Thermal Characterization Methods of Biostimulants Based on Sodium Humate
Authors: Stoica Rusandica , Oancea Florin , Minca Iulian , Doncea Sanda Maria , Ganea Rodica , Capra Luiza , Senin Raluca , Mateescu Mariana , Ciobanu Irina , Ivan Georgeta , Manolache Mihaela
Published: February 2020

Plant biostimulants, an emerging class of agricultural inputs, are complex products. The reproducibility of their specific action on plant metabolism and plant physiology, which lead to an enhanced nutrient use efficiency, stress tolerance and edible yield quality, is still a challenge. Development of quality insurance systems for plant biostimulants need complex investigation based on adapted analytical, physico-chemical and chemical methods. The objective of this work was to characterize commercial humate biostimulants through different analytical techniques (Fourier transform infrared spectroscopy - FTIR, thermogravimetric analysis- TGA) and to evaluate their textural and chemical (pH, C, N, humic acids, inorganic components) parameters. The first derivative curve from TG analysis showed decomposition of different compounds, classified according to the results obtained by FTIR. The humic substances determined by TGA method was comparable with the results obtained by gravimetric reference method. The inductively coupled plasma-optical emission spectrometry (ICP-OES) technique was applied to determine the inorganic elements either from the production process of humate or from raw materials, as well as for the control of humate in terms of requirements for safety and quality. Their complementary properties obtaining through different analytical techniques provide essential information on the chemical characteristics of the humate plant biostimulant formulations.
Evaluation of the Raphanus Sativus Varieties Response to the Application of Dinitrophenol in Terms of Oxidative Stress Enzymes and DNA Amplification
Authors: Todirascu-Ciornea Elena , Grosu Elena , Dumitru Gabriela , Bucur Diana , Gorgan Lucian
Published: February 2020

The oxidative stress at the vegetable organisms represents a complex chemical and physiologic phenomenon which appears as a result of the different influence of biotic and abiotic stressor factors, the negative strong impact of these ones being due to the massive superproduction and to the accumulation of the oxygen reactive species. The present material demonstrate the dinitrophenol phytotoxicity, chemical agent which enters in composition of lots pesticides, on the Raphanus sativus var. sativus species viability, the M�nchen Bier and French Breakfast varieties cropped in lab conditions through antioxidant enzymes� activity modifications, but also to those appeared at the genome�s level.
Early Degeneration of Aortic Bioprosthetic Valves Chemical interactions, prevention and treatment
Authors: Oancea Andra , Cobzeanu Maria Luiza , Tarus Andrei , Enache Mihail , Perianu Lacramioara
Published: February 2020

Bioprosthetic heart valves ensure a better quality of life compared to mechanical valves but are prone to degeneration with leaflet calcification and tearing. Valvular leaflets mineralization process is initiated within interstitial cells devitalized by glutaraldehyde with formation of calcium phosphate hydroxyapatite crystals. The aim of the current paper is to analyse early bioprosthetic valve degeneration occurring in three patients that needed bioprosthetic valve explantation and reimplantation of a mechanical valve. The three patients, aged 29, 64 and 78 years presented early degeneration of the implanted valve at 30, 36 and 52 months after the intervention in the context of unavoidable risk factors like young age, chronic kidney disease and small stented valve. Computed tomography examination demonstrated calcifications of the bioprosthetic valve and histological examination confirmed the findings by identifying tissue degeneration with calcification in all cases. Early bioprosthetic valve degeneration is a serious issue in cardiovascular surgery and a major cause of valve failure requiring reintervention. Several methods could be used to delay degeneration like systemic therapy with general anti-calcification agents, the use of locally delivered drugs or tissue pretreatment with special substances (ethanol, nonionic detergents, tridecyl alcohol ethoxylate). No optimal decellularization method for all types of tissues has been yet discovered. In conclusion, early bioprosthetic valve degeneration is a reality that should be taken into account in high risk patients. Current tissue pretreatment with glutaraldehyde is not perfect as it accelerates degeneration with formation of hydroxyapatite calcifications. New methods are needed to achieve efficient decellularization while preserving the functional characteristics of the transplanted tissue.
Mild Chronic Hyponatremia and Osteoporotic Fractures Risk in Elderly
Authors: Trifanescu Raluca Alexandra , Soare Dan , Carstoiu Catalin , Popescu Gheorghe , Pascu Alina Mihaela , Poroch Vladimir , Toma Sebastian , Poiana Catalina
Published: February 2020

Low serum sodium levels were associated with increased prevalence of osteoporosis and fractures. The aim of the study was to assess the relationship between serum sodium and bone mineral density and/or osteoporotic fractures� prevalence in elderly people. A total number of 260 patients (23 men / 237 women), aged 66.5 � 12.8 years, were retrospectively assessed. Serum sodium levels were measured in all patients. Bone mineral density (BMD) was measured by dual X-ray absorptiometry (DXA). Results: serum natremia was 140.3 � 4.4 mmol/L; prevalence of hyponatremia was 7.3%; frailty fractures were present in 117 out of 260 patients (45%). Patients with fractures had lower serum sodium levels as compared to patients without fractures (139 � 3.9 vs. 141.5 � 4.6 mmol/L, p [ 0.001). Patients with osteoporosis (n = 179) also showed lower natremia as compared to patients with normal BMD and osteopenia (n = 81): 139.9 � 4.7 vs. 141.2 � 3.8 mmol/L, p = 0.035. In patients admitted in the hospital for fractures (n = 92), prevalence of hyponatremia was 13.04%. Hyponatremic patients had significantly higher prevalence of fractures (73.7% vs. 42.7%, p = 0.0147) as compared to normonatremic patients. Odds ratio (OR) for fractures in patients with hyponatremia was 3.75 [95% C.I.: 1.3-10.75], p = 0.0138; OR for hip fractures in patients with hyponatremia was 3.65 [95% C.I.: 1.38-9.64], p = 0.0089. Both incidence and prevalence of hyponatremia increase with age, especially in patients treated with diuretics. Several clinical studies found an association between mild chronic hyponatremia in elderly and increased odds ratio of osteoporosis at the total and at femoral neck; the study also showed an increased odds ratio for all fractures and for hip fractures in hyponatremic patients. Elderly people at risk of osteoporotic fractures should have sodium serum measured.
2-Substituted Benzimidazole Synthesis in Dry Medium Mediated by Pyridine N-oxide
Authors: Bratulescu George
Published: February 2020

Substituted benzimidazoles were obtained from o-phenylenediamine and organic halides in solvent-free medium. The procedure involves pyridine N-oxide as mild oxidizing agent. The benzimidazoles were prepared without the separation of the intermediates. The absence of catalysts and good yields are important benefits of the method.
Evaluation of Rremineralization Capacity of Non-fluoride Home Products
Authors: Negraia Dan , Stoleriu Simona , Iovan Gianina , Nica Irina , Georgescu Andrei , Topoliceanu Claudiu , Andrian Sorin , Lacatusu Diana
Published: February 2020

The aims of the study were to characterize enamel, dentine and cementum surface aspect after using non-fluoride remineralization toothpastes containing calcium carbonate and calcium glycerophosphate by SEM evaluation, to determine chemical composition of enamel, dentin and cement after remineralization products application by EDX assessment, and to compare the remineralization capacity of the tested products. Ten extracted teeth having no dental caries, erosive or wear lesions were selected for the study. The teeth were split bucco-lingually and mesio-distally in four pieces. A free window of enamel, dentine, and cementum (4X4 mm) in the cervical area of the slices was preserved. In control group the slices were subjected to a artificial caries lesion formation. In study groups EcoBio� (President Company), Bio-natural (Dentissimo, Swiss Biodent), and Arthrodont Cassic (Pierre Fabre Oral Care) toothpastes were applied two times a day, for 3 minutes during caries lesion formation. The surface topography has been analyzed using a scanning electron microscope and the quantitative and qualitative chemical composition has been evaluated using an EDX detector. Interprismatic and intraprismatic mineral loss is clearly visible at higher magnification in enamel samples in control group. Some areas of demineralization are still present, and also small areas of extern deposits are visible on enamel, dentine and cementum samples in the groups were tested products were applied. All the tested toothpastes increased calcium and phosphorous ion concentrations in enamel, dentine and cementum. The highest remineralization effect was recorded in enamel by Dentissiomo, followed by Arthrodent and EcoBio toothpastes. In dentine and cementum the highest remineralization effect was registered by Arthrodent, followed by Dentissiomo and EcoBio toothpastes.
Specific Adverse Effects of Bevacizumab in the Treatment of Non-Squamous Non-Small Cell Lung Cancer (NSCLC) in Clinical Practice
Authors: Mazilu Laura , Stanculeanu Dana Lucia , Gheorghe Andreea Daniela , Suceveanu Adrian Paul , Hainarosie Razvan , Parepa Irinel Raluca , Bratu Ovidiu , Diaconu Camelia Cristina , Manuc Daniela , Stoian Anca Pantea , Suceveanu Andra Iulia
Published: February 2020

Lung cancer is the most common cause of cancer-related mortality, and non-small cell lung cancer (NSCLC) represents about 85% of all lung cancers. In the last years, novel targeted therapies have been developed and approved in the treatment of NSCLC. Angiogenesis is a very complex process, and cancer angiogenesis is the most important event concerning cancer growth, invasion and metastasis. VEGF signalling pathway plays a significant role in cancer angiogenesis, and it is demonstrated that VEGF levels are correlated with increased angiogenesis and with poor prognosis and metastasis in NSCLC patients. Bevacizumab is a recombinant humanised monoclonal IgG1 antibody, it is one of the first agent used for anti-angiogenic treatment, and it was approved for the treatment of non-squamous NSCLC in combination with chemotherapy.
Quantification of N-Terminal Procollagen I Propeptide in Patients With Occlusal Trauma Induced by Prosthetic Factors
Authors: Pendefunda Arina Alice Ciocan , Popa Cosmin Gabriel , Anistoroaei Daniela , Luchian Ionut , Iftene Gabriela , Martu Silvia , Forna Norina Consuela
Published: February 2020

Occlusal trauma can be generated by a number of local factors, including incorrect dental prosthetic systems. Proper therapy can lead to improved tissue homeostasis, with an increase in bone neoformation, whose markers include the N-terminal procollagen I propeptide (PINP). The purpose of the study was to determine serum N-terminal procollagen I propeptide levels in patients with occlusal trauma caused by incorrect prosthetic systems, performed before and after the establishment of perio-prosthetic complex therapy. The study was performed on a group of 56 patients with periodontal disease and prosthetic systems generating nonphysiological, traumatic occlusal forces. These patients underwent the clinical examination, appropriate multidisciplinary therapy, and N-terminal procollagen I propeptide levels were evaluated in the serum at baseline, 6 months, and 12 months after the therapy completion. The results demonstrated significant improvements for periodontal parameters in both post-treatment assessments and an increase in N-terminal procollagen I propeptide, more significant at one year after treatment.
DSC and FT-IR Analysis for the Formulation of Dermal Films with Meloxicam in Bioadhesive Polymeric Matrices
Authors: Todoran Nicoleta , Antonoaea Paula , Rusu Aura , Ciurba Adriana , Birsan Magdalena , Redai Emoke
Published: February 2020

The film forming polymers have a primary role in controlling the diffusion of the drug molecules and the bioavailability, its compatibility with the drug being an essential factor of the formulation. This study aimed the thermal analysis by Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared Spectroscopy (FTIR) evaluation of meloxicam associated with HPMC E5, HPMC 15000 and ethylcellulose, in order to identify the compatibility of associations. The results showed that meloxicam has minor interactions in binary or ternary physical mixtures with the three studied polymers, proving that the mixtures are suitable for obtaining bioadhesive matrices by casting and solvent evaporation method.
Effects of Statin Therapy in Patients with Stroke and Atheromatosis
Authors: Grosu Cristina , Mastaleru Alexandra , Nita Otilia , Cobzaru Roxana Gabriela , Rapa Carmen Valerica , Leon-Constantin Maria Magdalena , Cojocaru Elena
Published: February 2020

Recent studies have shown that as the average life expectancy increases, more people will suffer a stroke in their lives, diminishing their quality of life. Secondary stroke prevention involves reducing the cardiovascular risk factors and administering medication for preventive purposes, where statins play an important role. The purpose of this study is to highlight the correlations of statins dosage with cardiovascular risk factors (atheromatosis, uric acid value, obesity, etc), in stroke patients receiving hypolipidemic treatment with statins.
Effects of Electromagnetic Field Use on Jaw Bone Densification
Authors: Bechir Edwin Sever , Bechir Farah , Vladila Bogdan
Published: February 2020

The working hypothesis started from the premise of the benefits of the electromagnetic field therapy (EMFT) benefits in order to densify the periodontal bone tissues. The objective of this study was to quantify the results of using this therapy with the Electronic Doctor Stem Generator (EDSG) in the densification of affected alveolar bone tissues by clinical and radiological examinations. The study was performed on 30 patients, who benefited from adjuvant therapy in the electromagnetic field (EMF) with the EDSG device after performing the specific dental treatments. We applied these very low-frequency EMF bioactivation treatment delivered by EDSG device, 30 daily exposures for a 2-hour interval. The results proved the appreciable reduction of teeth mobility, the reduction of periodontal pockets depth and the bone regeneration in the regions exposed to the EMF produced by EDSG device. EMF adjuvant therapy with EDSG device is an innovative, atraumatic and non-invasive therapy.
Stress-induced Perioperative Depressive Symptoms
Authors: Scarinci Fabio , Saponaro Angelo , Patacchioli Francesca Romana , Ghiciuc Cristina Mihaela , Cozma Sebastian , Damian Lisandra , Cozma Lucia Corina Dima
Published: February 2020

Sustained stress has been correlated with increases in cortisol levels and decreased levels of brain transmitters including serotonin or dopamine. As a result of better understanding of human pathophysiology and pain physiology, the fields of surgery and anesthesia have seen major advances in the last years.However, a high percentage of patients develop depressive symptoms following major surgery and pathogenic perspective is very complex and require an holistic approach.
The Role of Tranexamic Acid in Controlling Bloodloss During PCNL for Staghorn Calculi
Authors: Barbilian Raluca Costina , Cauni Victor , Mihai Bogdan , Buraga Ioana , Dragutescu Mihai , Jinga Mariana , Mischianu Dan
Published: February 2020

The aim of this paper is to assess the efficiency and safety of the tranexamic acid in reducing blood loss and the need for transfusion in patients diagnosed with staghorn calculi treated by percutaneous nephrolithotomy. Percutaneous nephrolithotomy (PCNL) is a minimally invasive technique used for large kidney stones. Hemorrhagic complications and urinary sepsis are serious complications associated with this type of surgery. Tranexamic acid is an antifibrinolytic drug that has the property of reducing intra or postoperative bleeding. The experience with tranexamic acid in preventing blood loss during percutaneous nephrolithotomy for is limited. The use tranexamic acid in percutaneous nephrolithotomy for staghorn type stones is safe and is associated with reduced blood loss and a lower transfusion rate.
A Rare Case of a Lower Lip Merkel Cell Carcinoma Diagnosis and treatment
Authors: Raducu Laura , Cozma Cristina Nicoleta , Balcangiu Stroescu Andra Elena , Panduru Mihaela , Avino Adelaida , Tanasescu Maria Daniela , Badita Daniela Gabriela , Jecan Cristian Radu
Published: February 2020

Merkel cell carcinoma is (MCC) a rare type of skin malignancy that appears as a result of a disorganized multiplication of the Merkel cells and has a high rate of recurrence and metastases even from early stages. We describe the case of an 84-year old women diagnosed with Merkel cell carcinoma of the lower lip. Surgical treatment was realised with tumor excision and reconstruction using advancement flaps. Postoperative cosmetic and functional results were excellent, but invasion of the lateral margins, the patient�s decision of refusing re-excision and delayed radiotherapy lead to a rapid recurrence within 3 weeks. Responsiveness to subsequent radiotherapy was very good with regression of the recurrent tumor and decreasing of the local discomfort. Surgical treatment Merkel cell carcinoma of the lip is sometimes very challenging for a surgeon due to the necessity of wide resection and of the patient�s cosmetic concern. Radiotherapy remained an efficient therapy of Merkel cell carcinoma and should be used as a single or adjuvant therapy in situations where surgery cannot be applied, cisplatin chemotherapy being used for metastasis.
Numerical Modelling of a Town Water Distribution Network Optimum location of quality sensors
Authors: Lazar Gheorghe I. , Constantin Albert Titus , Ghitescu Marie Alice , Nicoara Serban Vlad
Published: February 2020

The analysis following a numerical simulation aims to establish the water distribution system vulnerability to a contaminant release and so to estimate the optimum locations of several quality sensors to warn against the pollution effects. The TEVA-SPOT software toolkit (as specific EPANET extension) was engaged upon a study case regarding the water distribution network of Ortisoara Town in Timi� County (4385 inhabitants). Five sets of sensors were consecutively considered for the numerical modelling, the engaged sensors being set for three values of the detection limit and of the response time. Assumed as a possible scenario, the designed sensors had to monitor the impact of injecting (at different given moments and network nodes) two types of contaminants (chemical and biological).
Salivia Officinalis L. and Verbascum Phlomoides L. Chemical, Antimicrobial, Antioxidant and Antitumor Investigations
Authors: Marian Eleonora , Vicas Laura Gratiela , Jurca Tunde , Muresan Mariana , Pallag Annamaria , Stan Roxana Liana , Sevastre Bogdan , Diaconeasa Zorita , Ionescu Corina Maria Lucia , Hangan Adriana Corina
Published: February 2020

Due to the fact that the therapeutic activity of the Salvia officinalis L. is well-known, we aim to evaluate the therapeutic properties of the Verbascum phlomoides L. In the present study, we conducted extractive solutions of the both plant species after having undergone lyophilization for a better preservation of the active extracted ingredients. Lyophilized extracts were evaluated in terms of chemical composition. The polyphenolic content of the extracts was obtained using HPLC method, while the total polyphenol content (expressed in gallic acid) and total flavonoids content (expressed in quercetin) were quantified using spectrophotometric methods. The studies carried out have shown the protective effect of plant extracts against free radicals � antioxidant properties assessed by various methods (DPPH method, FRAP method, TEAC method, SOD-like activity in vivo), the antimicrobial activity and cytotoxicity assays. After evaluating the therapeutic properties of freeze-dried extracts of the two plants, they will be associated in the formulation of a mouthwash with known therapeutic properties.
Effect of Osteoplasty with Bioactive Glass (S53P4) in Bone Healing - In vivo Experiment on Common European Rabbits (Oryctolagus cuniculus)
Authors: Arpad Solyom , Trambitas Cristian , Matei Ecaterina , Vasile Eugeniu , Pal Fodor , Antoniac Iulian Vasile , Voicu Stefan Ioan , Bataga Tiberiu , Fodor Raluca
Published: February 2020

Osteoplasty, is a procedure mostly applied in complicated bone fractures. Nowadays this method is widely used in primary fracture treatment while the native bone graft is progressively replaced with various synthetic bone substitutes. From the numerous bone grafts we�d like to mention a representative of ceramics, the S53P4 bioactive glass. (BonAlive�). The aim of this study was to investigate the healing process of different fracture types generated on rabbit femurs. During this experiment we used seven common European rabbits. We separated these animals into two groups; in the first group we surgically generated a total fracture in the middle 1/3 of the femur, while in the second group, we produced only a bone defect on the femur. The osteoplasty was carried out with bioactive glass and autologous bone grafts. The radiographic follow-up was immediate after the operation and after 3, 6 and 7 weeks. The animals were euthanized after 19, 20 and 21 weeks, for histomorphometric examination of the femur. It was also studied the ionic release from the used bioactive glass at physiological pH and the etching of the glass was studied by Scanning Electron Microscopy.
Electrochemical Characterization of Some Pyrrolo[1,2-c]Pyrimidine Derivatives
Authors: Tatu Marian Laurentiu , Harja Florian , Ungureanu Eleonora Mihaela , Georgescu Emilian , Popa Marcel Mirel
Published: February 2020

The electrochemical characterization of two pyrrolo[1,2-c]pyrimidine derivatives (I1 and I2) was realized by cyclic, differential pulse, and rotating disk electrode voltammetric methods. The character of redox processes was established by scanning on different domains and with different scan rates. The diffusion coefficients were determined. Modified electrodes have been obtained by cycling the potential or by controlled potential electrolysis at anodic potentials. The electrodes obtained with polyol1 and polyI2 films were characterized by cyclic voltammetry in ferrocene solution.
Implications of Digital Image Processing in the Paraclinical Assessment of the Partially Edentated Patient
Authors: Antohe Magda Ecaterina , Forna Doriana Agop , Dascalu Cristina Gena , Forna Norina Consuela
Published: February 2020

The application of certain digital processing techniques offers the possibility of extra accuracy in the interpretation of paraclinical examinations of this type, with profound implications in the diagnosis as well as in the hierarchy of the treatment plan. The purpose of this study is to identify the type of imaging processing for the identification of pathological elements from orthopantomographies and articular tomographies. A number of 20 orthopantomographies and 15 temporo-mandibular joint tomography have undergone through various image enhancement techniques. Various methods of image enhancement (enhancement) have been used for those procedures whereby it becomes more useful in the following aspects: specific details are highlighted; noise is eliminated; the image becomes more visually attractive. The workings were done in Corel PhotoPaint 7.0, using the automatic procedures available.The choice of a particular type of image enhancement technique has been selected for each type of pathology found in orthopantomographies or articular tomography, providing the best accuracy for an optimal imaging interpretation that underpins a precision diagnosis.Of the most useful imaging processing in the optimization of the orthopantomographic image accuracy the point-to-point transformations are to be noted. The image processing proposed in this article focused primarily on improving the radiological image attributes to highlight specific anatomical structures, and secondly, the contour detection, where it was necessary for the diagnostic purposes as well.
Determination of Isocyanates in Workplace Atmosphere by HPLC
Authors: Hegedus Ondrej , Smotlakova Zuzana , Hegedusova Alzbeta , Dubajova Jarmila , Andrejiova Alena , Jakabova Silvia , Tonk Szende , Szep Robert , Pernyeszi Timea
Published: February 2020

Determination of diisocyanates in the laboratories of the Authorities of Public Health was described and verified. Air samples collected in the breathing zone of workers exposed to diisocyanates were analyzed in an automotive industry. Diisocyanates (2,4-toluene diisocyanate, 2,6-toluene diisocyanate, 4,4�-methylenediphenyl isocyanate, and 1,6-hexamethylene diisocyanate) were measured by HPLC and the validation characteristics were determined. Diisocyanate exposure was monitored in the workplace atmosphere of 25 workers. Air samples from the breathing zone were collected and analyzed by HPLC after extraction. The results were compared to the occupational exposure limit. Reliability of the method was confirmed by validation characteristics for the diisocyanates. The repeatability of the method ranged from 2.98 to 4.51%, the calculated relative standard uncertainty was 11 � 12% for the parameters, and the recovery was between 99 and 103%. The low LOD and LOQ ensured the determination of the diisocyanates in the harmful concentration. Monitoring of diisocyanate exposure was performed on four different workplaces. The results showed that 2,4-toluene diisocyanate and 2,6-toluene diisocyanate were present in the concentration range from 6.3 to 13.2 �g m-3. The 1,6-hexamethylene diisocyanate was found in all cases below the limit of detection and the 4,4�-methylenediphenyl isocyanate was found only at two workplaces (between 8.3 and 44.8 �g m-3). The HPLC method was found to be appropriate for the determination of diisocyanates. Applying the method for the determination of diisocyanate exposure in four different workplaces, which produce car accessories, showed that the diisocyanate level did not exceed the occupational exposure limit set for average exposure.
Structure and Properties of Some Metallic Biomaterials from System Ti-Nb-Fe Used in Implantology
Authors: Predescu Cristian , Ciuca Sorin , Predescu Andra , Banu Alexandra , Pantilimon Cristian , Matei Ecaterina , Sohaciu Mirela , Berbecaru Andrei , Coman George
Published: February 2020

In this study special biomaterials from Ti-Nb-Fe system are obtained under two conditions of cooling from the liquid state. As a result of structural investigations, the constitution is biphasic a+ b with a proportion of b phase increasing with cooling rate. Also, the corrosion tests demonstrate that obtained alloy by fast cooling rate had a better corrosion resistance.
The Influence of Progesterone on Immunohystochemical Markers in Endometriosis
Authors: Mehedintu Claudia , Antonovici Marina , Brinduse Lacramioara , Bratila Elvira , Stanculescu Ruxandra , Berceanu Costin , Bratu Ovidiu , Pituru Silviu , Onofriescu Mircea , Matasariu Daniela Roxana
Published: February 2020

Endometriosis, one of the most common gynecologic pathologies, is defined as an inflammatory, estrogen-dependent disease characterized by the growth of endometrial stroma and glands outside the uterine cavity. It is a multifactorial disease, conditioned by genetic and immune factors and triggered by hormonal and environmental factors. Estrogen receptors (ER) and progesterone receptors (PR) expression is significantly modified in endometriotic tissue, compared to normal endometrium. We performed a prospective study that included 16 patients with endometriosis: 9 patients that underwent progesterone treatment with 0.075 mg desogestrel, daily for 24 weeks prior to the surgical procedure, and 7 patients that did not follow any kind of treatment. The purpose of the study was to evaluate the changes that occurred in the expression of ER, PR, B-cell lymphoma 2 (Bcl-2) and Ki-67 from the endometriotic tissue. Oral 0.075 mg desogestrel administration proved its benefits in the management of endometriomas.
Fish Ladder Numerical Modelling
Authors: Constantin Albert Titus , Ghitescu Marie Alice , Lazar Gheorghe I. , Nicoara Serban Vlad
Published: February 2020

The paper presents a 1D numerical modeling of the sanitary water flow passing through a fish ladder designed for the low head step built across the Alb (White) River near Coroiesti Vilage in Hunedoara County. The model aims to evaluate the water velocity spectrum, emphasizing the maximum values, in the cross sections along this passing structure and in the same time to establish the water levels development. In order to reach this goal, the numerical model will consider a sinthetical hydrograph based on the maximum value of the sanitary water flow required on the river.
ZnO and TiO2 Nanoparticles Genotoxicity According to their Structural and Morphological Characteristics Used for Medical Purposes
Authors: Glod Mihai , Damir Daniela , Nichitus Simona , Calin Gabriela , Duceac Letitia Doina , Gorgan Dragos Lucian , Tascu Sorin , Ciuhodaru Madalina Irina
Published: February 2020

Defined by their small size, nanomaterials rapidly developed due to their physicochemical properties at nanoscale. Nanoparticles possess a high biological reactivity compared to their bulk size suggesting a high toxicity when the genetic material is involved. Nanogenotoxicity field refers to multidisciplinary sciences relevant for evaluation of genotoxic effect of various nanostructured materials. Due to their widespread use in medical area, zinc oxide and titanium dioxide nanoparticles are receiving researcher�s attention. The major objective of this work was to find a relationship between the structure and morphology of ZnO and TiO2 nanoparticles and their genotoxic potential.
Flammability of Some Vegetal Oils on Hot Surface
Authors: Georgescu Constantin , Cristea George Catalin , Solea Catalin Liviu , Deleanu Lorena , Sandu Ioan Gabriel
Published: February 2020

Vegetal oils could be a solution to replace mineral oils, but their atypical behavior constrains users to test them. Tests on hot surface were done with the help of an original test equipment. The method is designed to imitate the worst scenario that could happen when fluid leakage reaches hot surfaces. The ignition temperature on hot surface for the tested vegetal oils is in a narrow range (495...510oC), higher than most mineral oils, this being due to the similar composition in fat acids.
The Prophylactic Orthodontic Treatment with Removable Appliances in Children
Authors: Romanec Cristian , Dragomir Bogdan , Bica Cristina
Published: February 2020

Childhood and adolescence include periods of growth in which the pediatrician meets multiple challenges in terms of cooperation, compliance with treatment, and the patient�s family, thus constituting the pedodontic triangle. The importance of long-term patient monitoring should not be neglected, especially for those in the stage of growth and development of temporary or permanent dentition, when a real cascade of bad events can be triggered. Mobile dental appliances with the indication to be worn both day and night, less during meals and when tooth cleaning is taking place. They are used for a relatively short period as part of a wider treatment plan. The efficiency of an orthodontic appliance is appreciated by the possibilities it offers to reach the desired result in a minimum treatment time, without affecting the biological integrity of the substrate on which it operates. Ortodontic mobilisable devices used to correct dento-maxillary abnormalities, requires plates with orthodontic force, retention and anchoring. If these are used as contention devices, is needed only retention. Study group regards the selection, examination and orthodontic treatment of 46 cases at the Orthodontic Clinic of the University of Medicine and Pharmacy T�rgu Mure� between 2014-2016.The study deals with the theoretical aspects regarding biomechanics and the principles of orthodontic treatment and at the same time represents a synthetic exposure characteristics of the orthodontic devices, considering the development of new techniques. Orthodontic treatment begins in childhood, around the age of 6 years old or when the child has 4-6 milk teeth, when we already can see problems in growing of jaw and permanent teeth.
The Role of Chromogenic and Immunoturbidimetry Assays in Diagnostic of Thrombotic State in Myeloproliferative Disorders
Authors: Badulescu Oana Viola , Vintila Dan , Sirbu Paul Dan , Ciuntu Bogdan Mihnea
Published: February 2020

Polycythaemia vera (PV) is a monoclonal myeloproliferative disorder characterized by a haemostatic imbalance resulting in increased risk for thrombotic events. In PV there is an important affection of the vascular endothelium, so we analized in our study three markers of endothelium disfunction- von Willbrand factor (vWF), Protein C (PC) and the inhibitor plasminogen activator type-1. (PAI-1) The study comprised 40 patients and the objective of the study was to investigate the level of the mentioned parameters in two groups of patients-the group of polycytemic patients without cardiovascular diseases (PV) and the group of polycitemic patients with cardiovascular pathology associated (PV+CVD). The levels of the studied parameters were found significantly modified in the PV group (p[0.05); for the PV+CVD group the level of vWF was higher (p[0.001), but the levels of the other parameters, didn�t show a significant statistic difference compared with the first group (p]0.05). In accordance with the presented results, the conclusions of our study was that in PV the risk of thrombotic accidents is related by the increase of the vWF level, as the vascular endothelium plays a key role in this pathology.
Salivary and Serum Biochemical Alterations in Patients with Acute Viral Hepatitis
Authors: Badita Daniela Gabriela , Stanescu Iulia Ioana , Stroescu Andra Balcangiu , Sianu Dan Piperea , Miricescu Daniela , Calenic Bogdan , Greabu Maria
Published: February 2020

Viral hepatitis represents a major health problem worldwide. Approximately 1.4 million people are infected with hepatitis A virus every year, although given that most of the cases evolve asymptomatically the real number could be even higher. At the same time, hepatitis B virus affects up to 30% of the world population and represents one of the main causes of cirrhosis and hepatocellular carcinoma. Thus, it is very important to understand the physiopathology of viral hepatitis A and B not only for the diagnosis, but also for the therapeutic protocol. The present research aimed to determine if HAV and HBV can alter serum and salivary levels of total protein and of 2 important electrolytes: calcium and potassium.
The Role of Anticoagulant Therapy with Heparine in Treatment of Acute Hand Ischemia
Authors: Zeca Cristina Elena Berbecar , Iordache Madalina Elena , Muraru Iulia , Muraru Dragos , Stanciulescu Elena Luminita , Jinescu George , Maciuceanu Zarnescu Mircea Bogdan , Mares Alina Monica
Published: February 2020

Hand ischaemia has multiple causes. The Methadone (C21H27NO) - opioid family of drugs and Alprazolam (C17H13Cl1N4) microcrystals, available under the trade name Xanax - benzodiazepine anxiolytic, when using in case of drugs abuser, are very powerful embolic agents which can cause thrombosis of small vessels. Microvascular embolization caused by microcrystals of the injectable powder has contributed to the process of ischaemia. This paper brings into discussions a case of acute ischaemia of the right hand due to intra-arterial injection of suspended tablets of Methadone and Alprazolam microcrystals into the right radial artery, in the distal 1/3 of the forearm.The therapeutic management consisted of restoring the arterial circulation at the ischaemic segment to prevent the propagation of thromboembolic complications by using of i.v. heparine and to preserve the function of the hand by preventing delayed ischaemia and compartment syndrome followed by necrosis. Heparin is a drug widely used in the treatment and prevention of arterial and venous thrombosis. The main effect of heparins lies in their anticoagulant activity. Heparins are involved in different pathways of the coagulation cascade with anticoagulant, antithrombotic, profibrinolytic, anti-aggregative, as well as anti-inflammatory effects.This paper aims to discuss a severe case of ischaemia which demonstrates that intra-arterial injection of oral drugs can lead to limb loss with currently accepted therapy.
Study of the Drug Diffusion Through Polymeric Membranes
Authors: Grosu Elena , Trifoi Ancuta , Rapa Maria , Gherman Timea , Turcanu Andreea , Filip Petru
Published: February 2020

We present the studies carried out on the transport properties of some membranes obtained from synthetic polymers: polyurethane and ethylene-vinyl acetate copolymer, for use in the development of transdermal therapeutic systems with limiting membranes of speed. The properties of drug active substances transport through membranes were highlighted by performing studies with a diffusion cell. Experimental drug active substances were paracetamol and tetracycline. The experimental data obtained was processed using a general mathematical model for drug release from non-porous, non-swellable transdermal devices, which starts from Fick�s second law and has terms that also take into account the possibility of retaining the drug in the membrane polymer. Even though the mathematical model does not take into account neither the swelling phenomenon nor the possibility of membrane erosion, a good agreement between model and experimental data was obtained. The values of effective diffusion coefficients of drug in the polymeric membranes were also determined.
Assessment of the Thermal Stability of Patulin in Apple Puree and of Possibilities for Reduction of Patulin Contamination Level Through Apple Processing
Authors: Catana Monica , Catana Luminita , Iorga Enuta , Culetu Alina , Ionescu Valentin , Belc Nastasia
Published: February 2020

Apples are an important raw material for the production of puree, nectar, jam, and a widely used ingredient in composition of pastry products. Patulin is a mycotoxin that appears in moldy apples, especially, attacked by Penicillium, Aspergillus and Byssochlamys. This study aimed to evaluate the thermal stability of patulin in apple puree and the possibilities to reduce the patulin contamination level through processing apples to apple puree and nectar. Within the experiments, samples of apple puree from Jonathan apple cultivar, spiked with patulin at four concentration levels (10 mg/kg, 20 mg/kg 40 mg/kg and 80 mg/kg) were heat treated at 100 �C for 10, 15, 20 and 25 min, respectively. It was found a reduction of the patulin level, due to the thermal degradation of this mycotoxin. Apples from Golden Delicious cultivar, attacked by Penicillium expansum and contaminated with native patulin were processed to puree and nectar. Through processing of apples contaminated with patulin it was registered an important decrease of it.
A Novel Jump-start System Based on Reconditioned Li-polymer Batteries
Authors: Benga Florin Mihai , Vaireanu Danut Ionel , Ciobotaru Ioana Alina , Ciobotaru Irina Elena
Published: February 2020

This paper introduces a method of reconditioning lithium-polymer batteries which are no longer performing as expected. The reconditioning process consists of consecutive charging/discharging steps at controlled currents and is followed by an evaluation procedure, in order to determine the actual performances of the reconditioned batteries. For the evaluation of the characteristics of the Li-polymer batteries, one has measured the charging capacity, the discharging capacity and the internal resistance. However, after the reconditioning stage, one must look for a new application for these batteries, as the reconditioned batteries are seldom behaving as the new ones to be used for the same initial designated application. We manufactured and tested a cold jump-start system, particularly useful in the case of cars flat batteries or cars batteries starting failure. The advantages of this system consist in their reduced mass and volume and a very powerful starting current, comparable to that of high capacity lead acid batteries, the system being able to act as multiple starting aids.
The Determination of the Noise Pollution in a Production Hall and the Diseases Produced by It
Authors: Chivu Oana Roxana , Mederle Ovidiu , Semenescu Augustin , Mates Ileana , Babis Claudiu , Demetrian Camelia , Negoita Olivia , Demetrian Alin
Published: February 2020

The paper describes how to determine the noise in a production hall where there are production machines and equipment. The chosen plant is a production unit where filling of the polyurethane foam tubes is performed. The main activity is the production of professional insulators and wholesale of other products from the same range enumerating the following: wholesale chemical products; production of professional insulators; trade in chemicals and chemical industry. The recommended maximum admissible value for a normal 8h work program is 85 dB (A). The objective is to determine the level of noise in the factory and how it acts as a physical professional risk factor and its effects on the human body. The way in which the proposed objective was achieved was to determine the value of the noise level with the specialized equipment. Following the determinations that will be presented in the following chapters, appropriate protective measures have been taken.
Odontal and Protetic Reconstruction in Total Coronar Fractures
Authors: Caraiane Aureliana , Raftu Gheorghe , Leata Razvan , Cerghizan Diana , Macovei Luana Andreea , Focsaneanu Sergiu Ciprian , Covaci Antonela Magdalena , Rusu Negraia Magdalena , Ilie Mariana , Dimofte Alina Ramona , Decusara Mioara
Published: February 2020

Beyond the acute character, two important aspects confer specificity to the dento-periodontal traumas: the age of the patients and the multidisciplinary attend of the therapeutic approach. The traumas, together with the dento-periodontal infections, are real pedodontic emergencies. Dento-periodontal traumas are lesions requiring careful examination to establish a correct diagnosis and a rapid establishment of appropriate treatment. They require a rapid diagnosis, an optimal therapeutic attitude, to resolve dento-periodontal structures and further harmonious development of the jaws. The coronary traumas that amputate the dental crown result from trauma that develop high intensity forces, with a point of application to the tooth cervical area, accompanied by other types of injuries. Radical status evaluation is performed paraclinically by imaging exploration methods. Information on root length, implantation, absence or presence of periapical diseases, endodontic treatment quality are fully provided by these methods.Clinically, the diameter of the roots of the teeth is evaluated. The analysis and synthesis of these data will allow the determination of the method of substitution and the planning of working methods. Material and Method: The study group comprises 39 children aged 6-16, most of them present for emergency treatment. Results and Discussion: The traumatic agent�s force exceeds the resistance and elasticity of tissues, causing discontinuities in the tissue structure, whether soft or rough. Conclusions: The provisional or final treatment of dento-periodontal traumas aims at restoring the morphological, functional and psychological integrity of the traumatized individual.
Chemical Senses- Smell and Olfaction
Authors: Decusara Mioara , Caraiane Aureliana , Macovei Luana Andreea , Ilie Mariana , Focsaneanu Sergiu Ciprian , Covaci Antonela Magdalena , Negraia Magdalena Rusu , Raftu Gheorghe
Published: February 2020

The mucosa of most of the nasal cavity has no olfactory function. The olfactory receptors are found in the nasal mucosa in a reduced region - the olfactory area, represented by the walls of a narrow niche formed by the upper nasal cornet, the upper septum and the roof of the nasal cavity (the cryobriform lamina of the etmoid). The smell is very similar to taste, being described by some as �taste at a distance�. Olfactive recipients adapt quickly. It is common that an unpleasant smell, at first very difficult to bear, becomes quickly inacceptable. Generally, the olfactory potential of some chemical compounds belonging to a homologous series grow progressively from the lower compounds of the series to the upper ones. The division of odors by category is a very difficult problem. In case of olfaction there are no fundamental qualities that can be compared with taste sensations: sweet, sour, bitter salty . The large number of perceptible odors asks a question to which the answer has not yet been found, namely: What is the mechanism behind the olfactory differentiation? .What can we distinguish between two odors?
Chemical Composition Assessment of Sulphurous Waters
Authors: Murarescu Ovidiu , Pehoiu Gica , Radulescu Cristiana , Dulama Ioana Daniela , Teodorescu Sofia , Stirbescu Raluca Maria , Muratoreanu George
Published: February 2020

The study aims to assess the chemical composition of sulphurous spring waters collected from Pucioasa � Vulcana Bai balneotherapeutical area, Dambovita County. The sampling were achieved from active and preserved sulphurous sources (i.e. five springs), during the summer period of the year 2016. The content of nine metals (i.e. Cr, Mn, Fe, Co, Ni, Cu, Cd, Zn, and Pb) in water samples was determined by Inductively Coupled Plasma - Mass Spectroscopy (ICP-MS). The relationships between physicochemical parameters (i.e. pH, conductivity, TDS, salinity, total hardness and dissolved oxygen) and metal concentrations were investigated, as well.