bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessing Healthcare Workers’ Knowledge and Their Confidence in the Diagnosis and Management of Human Monkeypox: A Cross-Sectional Study in a Middle Eastern Country
Authors: Sallam Malik , Al-Mahzoum Kholoud , Al-Tammemi Ala’a B. , Alkurtas Mohammed , Mirzaei Fatemeh , Kareem Nariman , Al-Naimat Hala , Jardaneh Laila , Al-Majali Laith , AlHadidi Akram , Al-Salahat Khaled , Al-Ajlouni Eyad , AlHadidi Nadin Mohammad , Bakri Faris G. , Harapan Harapan , Mahafzah Azmi
Published: September 2022

The ongoing multi-country human monkeypox (HMPX) outbreak was declared as a public health emergency of international concern. Considering the key role of healthcare workers (HCWs) in mitigating the HMPX outbreak, we aimed to assess their level of knowledge and their confidence in diagnosis and management of the disease, besides the assessment of their attitude towards emerging virus infections from a conspiracy point of view. An online survey was distributed among HCWs in Jordan, a Middle Eastern country, during May–July 2022 using a questionnaire published in a previous study among university students in health schools in Jordan. The study sample comprised 606 HCWs, with about two-thirds being either physicians (n = 204, 33.7%) or nurses (n = 190, 31.4%). Four out of the 11 HMPX knowledge items had <50% correct responses with only 33.3% of the study respondents having previous knowledge that vaccination is available to prevent HMPX. A majority of study respondents (n = 356, 58.7%) strongly agreed, agreed or somewhat agreed that the spread of HMPX is related to a role of male homosexuals. Confidence in the ability of diagnosis based on the available monkeypox virus diagnostic tests was reported by 50.2% of the respondents, while the confidence levels were lower for the ability to manage (38.9%) and to diagnose (38.0%) HMPX cases based on their current level of knowledge and skills. Higher confidence levels for HMPX diagnosis and management were found among physicians compared to nurses. The endorsement of conspiracy beliefs about virus emergence was associated with lower HMPX knowledge, the belief in the role of male homosexuals in HMPX spread, and with lower diagnosis and management confidence levels. The current study highlighted the gaps in knowledge regarding HMPX among HCWs in Jordan as well as the lack of confidence to diagnose and manage cases among physicians and nurses. Raising the awareness about the disease is needed urgently considering the rapid escalation in the number of cases worldwide with reported cases in the Middle East. The attitude towards male homosexuals’ role in HMPX spread necessitates proper intervention measures to prevent stigma and discrimination among this risk group. The adoption of conspiratorial beliefs regarding virus emergence was widely prevalent and this issue needs to be addressed with proper and accurate knowledge considering its potential harmful impact.
Actions Speak Louder Than Words: Health Behaviours and the Literacy of Future Healthcare Professionals
Authors: Chawłowska Ewelina , Staszewski Rafał , Zawiejska Agnieszka , Giernaś Bogusz , Domaradzki Jan
Published: September 2022

Our everyday behaviours in life can positively and negatively impact our health, thus cumulatively shaping our lifestyles as more or less healthy. These behaviours are often determined by our knowledge, literacy, motivations and socioeconomic backgrounds. The authors aimed to assess health behaviours and explore variables that may affect persons studying to become future healthcare professionals in Poland. This study was conducted with a group of 275 undergraduate students attending the Poznan University of Medical Sciences representing six different majors of study. We used self-reported, cross-sectional survey conducted through the use of a questionnaire that consisted of one standardised scale (Juczyński’s Health Behaviour Inventory) as well as a self-developed health literacy measure. The students showed average to high levels of health-promoting behaviours (mean HBI = 82.04 ± 11.26). Medium to strong associations were found between these behaviours and high scores on the health literacy scale (p = 0.001, r = 0.45 between total scores of the two scales). Dietetics students and female respondents scored significantly better on both scales, which suggests that their self-reported behaviours and health literacy were higher than those of other participants. Exhibiting health-protective behaviours and high health literacy is likely to result in the better individual health of our respondents, but, more importantly, will also influence their future professions. As members of the healthcare workforce they will be responsible for the health of the population and it is crucial for them not only to provide care, education, and guidance, but also to act as role-models for their patients and society.
Effect of Lockdown and Mass Testing for the SARS-CoV-2 Omicron Epidemic on Reducing New Infections in Shenzhen, China
Authors: Han Xinxin , Li Xiaotong , Zhu Bin , Zhao Wenjing , Huang Jie , Liu Gang , Gu Dongfeng
Published: September 2022

On 14 March 2022, China’s tech hub Shenzhen, a mega-city with more than 18 million inhabitants, imposed a one-week citywide lockdown immediately after it observed a surge in infections. We assessed the effect of this one-week lockdown, coupled with mass testing, on reducing the daily number of new confirmed cases and asymptomatic cases during the Omicron wave, using an interrupted time series analysis approach. Our analysis suggests that the one-week citywide lockdown in Shenzhen was effective at lowering both daily new confirmed cases and asymptomatic cases during the Omicron wave. Early detection ensures timely isolation and treatment of infected patients in designated hospitals, and therefore helps lower the prevalence of confirmed cases and asymptomatic cases. Our findings of the immediate increase in asymptomatic cases after lockdown warrant further verifications in other city epidemic scenarios.
A Cross-Sectional Assessment of Complementary and Alternative Medicine (CAM) Use among Patients with Chronic Diseases (CDs) in Qassim, Saudi Arabia
Authors: Farooqui Maryam , Alreshidi Hanan , Alkheraiji Jana , Abdulsalim Suhaj , Alshammari Mohammed Salem , Kassem Lamyaa , Hussein Samah , Ismail Wan Ismahanisa
Published: September 2022

This study aims to investigate CAM use among CD patients from Qassim, Saudi Arabia and to compare CAM practice with different demographic and disease characteristics of the participants. A cross-sectional study was conducted among CD patients. During the three-months of data collection period, a total of 377 patients were approached and 208 patients participated in the study, giving a response rate of 55.17%. A p value of <0.05 was considered as significant. Among the study population, 94 (45.2%) patients were CAM users. Diabetes mellitus patients were the majority (48 (51.06%)) followed by hypertensive patients (34 (36.17%)). Spiritual therapies were the most common CAM followed by herbal products. Among CAM users, 41 (19.7%) patients reported disclosing CAM use to their health care providers. Among all the sociodemographic variables, gender (p = 0.029), marital status (p = 0.034) and education level (p = 0.047) were significantly associated with CAM use. In conclusion, the use of CAM among CD patients was relatively high in Qassim. Patients reported using CAM without disclosing to their health care providers which is a major health risk. It is critical to counsel CD patients regarding rational and informed CAM use in order to prevent harmful and unwanted effects.
Cultivar-Specific Assessments of Almond Nutritional Status through Foliar Analysis
Authors: Pica Aniello Luca , Silvestri Cristian , Cristofori Valerio
Published: September 2022

Mediterranean almond growing is increasing, as confirmed in Italy where new almond orchards in areas not previously interested in this nut crop have been recently established. In these new areas, as in the coastal of Latium region, the knowledge of eco-physiological behavior as a complex interaction among cultivars, pedoclimate conditions and orchard management is still poor. Optimizing fertilization strategies according to cultivar needs is one of the main key factors to guarantee high yields and nut quality, as well as to reduce environmental pollution. With this aim, an almond field collection has been established planting medium- and late-bloom cultivars. During the growing seasons 2019–2020, leaf samples were collected at 90 and 120 days after full bloom (DAFB) analyzed for biometrical and eco-physiological traits and leaf nutrients content through foliar diagnostics. Differences in foliar nutrient content depend on both cultivar and phenological stage. According to Pearson correlation heatmap, leaf nitrogen content showed a medium–high positive correlation with Nitrogen Balance Index (NBI) either at 90 or 120 DAFB, highlighting reciprocal influences among leaf nutrient contents and some eco-physiological traits. The findings of this study will help to develop novel environmentally friendly nutrition and fertigation strategies supported by foliar diagnostics which also consider accurate cultivar requirements.
Development of Questionnaire on the Sense of Workplace Involution for Newly Recruited Employees and Its Relationship with Turnover Intention
Authors: Chen Qi , Zhang Yuzhu
Published: September 2022

The term “involution” has become a buzzword in people’s daily communication and online discussion in recent years, and it has been used in many different contexts. However, the concept and structure of workplace involution are still unclear, and there is a lack of valid measurement tools. Objective: To explore the connotation and psychological structure of newly recruited employees’ sense of workplace involution, compile the Questionnaire on the Sense of Workplace Involution for Newly Recruited Employees, and examine its relationship with turnover intention. Methods: Through in-depth interviews with 30 newly recruited employees and based on qualitative research of the data collected by web crawler technology, the entries were compiled, 282 newly recruited employees were initially tested, and 571 newly recruited employees were given a formal questionnaire survey. The findings were analyzed using SPSS 22.0 and AMOS 24.0 for item analysis, exploratory factor analysis, and confirmatory factor analysis. Results: The newly recruited employees’ sense of workplace involution and its dimensions were significantly and positively correlated with turnover intention. Newly recruited employees’ sense of workplace involution was a significant and positive predictor of turnover intention. Conclusions: The reliability and validity of the Questionnaire on the Sense of Workplace Involution for Newly Recruited Employees met the needs of psychometric criteria, and the sense of workplace involution of newly recruited employees had a significant positive predictive effect on turnover intention.
Quo Vadis Nordic Hamstring Exercise-Related Research?—A Scoping Review Revealing the Need for Improved Methodology and Reporting
Authors: Alt Tobias , Severin Jannik , Schmidt Marcus
Published: September 2022

The objective of this scoping review is to assess Nordic Hamstring Exercise quality (ANHEQ) of assessments and interventions according to the ANHEQ rating scales and to present practical recommendations for the expedient design and reporting of future studies. A total of 71 Nordic Hamstring Exercise (NHE) assessments and 83 NHE interventions were selected from the data sources PubMed, Scopus, and SPORTDiscus. Research studies which were presented in peer-reviewed academic journals and implemented the NHE during laboratory-based assessments or multi-week interventions met the eligibility criteria. NHE assessments analyzed force (51%), muscle activation (41%), knee angle kinematics (38%), and bilateral symmetry (37%). NHE interventions lasted 4–8 weeks (56%) and implied an exercise volume of two sessions per week (66%) with two sets per session (41%) and ≥8 repetitions per set (39%). The total ANHEQ scores of the included NHE assessments and interventions were 5.0 ± 2.0 and 2.0 ± 2.0 (median ± interquartile range), respectively. The largest deficits became apparent for consequences of impaired technique (87% 0-point-scores for assessments) and kneeling height (94% 0-point-scores for interventions). The 0-point-scores were generally higher for interventions compared to assessments for rigid fixation (87% vs. 34%), knee position (83% vs. 48%), kneeling height (94% vs. 63%), and separate familiarization (75% vs. 61%). The single ANHEQ criteria, which received the highest score most frequently, were rigid fixation (66% of assessments) and compliance (33% of interventions). The quality of NHE assessments and interventions was generally ‘below average’ or rather ‘poor’. Both NHE assessments and interventions suffered from imprecise reporting or lacking information regarding NHE execution modalities and subsequent analyses. Based on the findings, this scoping review aggregates practical guidelines how to improve the design and reporting of future NHE-related research.
Spatial Evolutionary Characteristics and Influencing Factors of Urban Industrial Carbon Emission in China
Authors: Zhang Xinyu , Shen Mufei , Luan Yupeng , Cui Weijia , Lin Xueqin
Published: September 2022

Climate warming caused by carbon emissions is a hot topic in the international community. Research on urban industrial carbon emissions in China is of great significance for promoting the low-carbon transformation and spatial layout optimization of Chinese industry. Based on ArcGIS spatial analysis, Markov matrix and other methods, this paper calculates and analyzes the temporal and spatial evolution characteristics of industrial carbon emissions in 282 cities in China from 2003 to 2016. Based on the spatial Dubin model, the influencing factors of urban industrial carbon emissions in China and different regions are systematically analyzed. The study shows that (1) China’s urban industrial carbon emissions generally show a trend of first growth and then slow decline. The trend of urban industrial carbon emissions in the western, central, northeastern and eastern regions of China is basically consistent with the overall national trend; (2) In 2003, China’s urban industrial carbon emissions were dominated by low carbon emissions. In 2016, China’s urban industrial carbon emissions were dominated by high carbon emissions, and the spatial trend is gradually decreasing from the eastern region to the central region to the northeast region to the western region; (3) In 2003, the evolution pattern of China’s urban industrial carbon emissions was “low carbon-horizontal expansion” dominated by positive growth, and in 2016, it was “low carbon-vertical expansion” dominated by scale growth; (4) China’s urban industrial carbon emissions have spatial viscosity, and the spatial viscosity decreases with the increase of industrial carbon emissions. (5) In 2004, the relationship between urban industrial carbon emissions and gross industrial output value in China is mainly weak decoupling. In 2016, various types of decoupling regions are more diversified and dispersed, and strong decoupling cities are mainly formed from weak decoupling cities in southwest China and eastern coastal areas; (6) From a national perspective, indicators that are significantly positively correlated with industrial carbon emissions are urban industrial structure, industrial agglomeration level, industrial enterprise scale and urban economic development level, in descending order. Indicators that are significantly negatively correlated with urban industrial carbon emissions are industrial structure and industrial ownership structure, in descending order. Due to the different stages of industrial development and industrial structure in different regions, the influencing factors are also different.
Physical Activity and Mental Health Declined during the Time of the COVID-19 Pandemic: A Narrative Literature Review
Authors: Amo Christina , Almansour Najla , Harvey Idethia S.
Published: September 2022

(1) Introduction: Mental health (MH) and physical activity (PA) share a bi-directional relationship, but most studies report MH as the outcome. With diminishing pandemic-related MH, this review examines the impact of diminished MH on PA. (2) Methods: This narrative literature review included 19 empirical studies published since the COVID-19 pandemic. Electronic databases such as MEDLINE, PsycINFO, and CINAHL were searched for English language articles in peer-reviewed journals using equivalent index terms: “anxiety”, “depression”, “stress”, “mental health”, “exercise”, “activity”, “COVID-19”, “coronavirus”, and “2019 pandemic”. The search reviewed 187 articles with double-rater reliability using Covidence. A total of 19 articles met the inclusion criteria. (3) Results: MH themes that impacted PA were depression and/or anxiety (n = 17), one of which identified inadequate coping and excessive pandemic stress (n = 2). In addition, women are more likely to suffer diminished MH and reduced PA throughout the pandemic. (4) Conclusion: Current research suggests that individuals with pre-pandemic MH episodes are correlated with more effective coping skills and fewer adverse effects from COVID-19 than expected. As we emerge from this pandemic, equipping all individuals, especially women, with positive coping strategies may accelerate a seamless return to PA.
Reactions to Pictorial and Text Cigarette Pack Warning Labels among Chinese Smokers
Authors: Wang Liu , Yao Xi , Wang Gang , Du Kecheng
Published: September 2022

Objectives. This study aims at examining the impact of graphic pictorial warning labels on inten-tion to quit smoking and perceived harms among Chinese working-age adults (n = 661). Methods. A randomized controlled trial is utilized as the research design by comparing three scenarios: Group 1 as baseline (n = 193) and presented with real market tobacco products with text-only la-bels, Group 2 as price group and with hypothetical scenarios of manipulated prices, and Group 3 as the imaging group and with hypothetical scenarios of graphic pictorial cigarette warning la-bels. Both bivariate and multivariate analyses are utilized to determine the effectiveness of warn-ing labels. Results. Graphic pictorial cigarette warning labels are associated with stronger inten-tion to quit smoking and greater perceived harms. Smokers have a greater number of attempts if they are less nicotine dependent and express greater smoking risk perceptions. Conclusions. This study adds to the evidence that graphic pictorial warning labels are more effective than text-only labels in increasing intention to quit smoking. As China strives to achieve a reduction in smoking to meet the goal of the Healthy China 2030 initiative, this work strengthens the evidence base for policy makers, practitioners, and researchers to design low-cost warning labels on cigarette packs to promote tobacco control.
Impacts of Pesticides on Oral Cavity Health and Ecosystems: A Review
Authors: Salazar-Flores Joel , Lomelí-Martínez Sarah M. , Ceja-Gálvez Hazael R. , Torres-Jasso Juan H. , Torres-Reyes Luis A. , Torres-Sánchez Erandis D.
Published: September 2022

Pesticides are chemical substances used to control, prevent, or destroy agricultural, domestic, and livestock pests. These compounds produce adverse changes in health, and they have been associated with the development of multiple chronic diseases. This study aimed to present a detailed review of the effect of pesticides on the oral cavity and the oral microbiome. In the oral cavity, pesticides alter and/or modify tissues and the microbiome, thereby triggering imbalance in the ecosystem, generating an inflammatory response, and activating hydrolytic enzymes. In particular, the imbalance in the oral microbiome creates a dysbiosis that modifies the number, composition, and/or functions of the constituent microorganisms and the local response of the host. Pesticide exposure alters epithelial cells, and oral microbiota, and disrupts the homeostasis of the oral environment. The presence of pesticides in the oral cavity predisposes the appearance of pathologies such as caries, periodontal diseases, oral cancer, and odontogenic infections. In this study, we analyzed the effect of organochlorines, organophosphates, pyrethroids, carbamates, bipyridyls, and triazineson oral cavity health and ecosystems.
Sociodemographic and Socioeconomic Factors Influencing the Body Mass Composition of School-Age Children
Authors: Baran Rafał , Baran Joanna , Leszczak Justyna , Bejer Agnieszka , Wyszyńska Justyna
Published: September 2022

The purpose of the study was to evaluate the components of overweight, obesity, and body mass components among children aged 7 to 13 years against important sociodemographic factors. The analyses considered 315 school-age children from 7 to 13 years of age (164 boys and 151 girls). Each subject was assessed for body weight and height, body weight category, and main sociodemographic factors. Body mass components of body mass (body-fat percentage (BFP), muscle tissue, fat-free mass (FFM), and total body water (TBW) levels) were evaluated using the electrical bioimpedance method (BIA) and the TANITA 780 MC analyzer. A statistical analysis showed significant differences between the body composition of children living in cities in relation to children living in small towns and villages, and no significant differences were found between the results of children living in small towns and children living in villages. The presence of statistically significant differences between the values of the parameters of body composition of the studied children was demonstrated depending on the level of education of their fathers. The presence of statistically significant relationships between BMI of mothers and BFP of their children (p = 0.003), FFM (p = 0.003), muscle tissue (p = 0.001), and TBW (p = 0.001) has been demonstrated. The higher content of adipose tissue in children is strongly dependent on the higher BMI and body mass category of the mother, as well as the lower level of education of the father. The place of residence also significantly affects both the body fat content and the total body water content of body hydration. Living in the city is associated with better body composition.
Comparison of Three Comorbidity Measures for Predicting In-Hospital Death through a Clinical Administrative Nacional Database
Authors: Oterino-Moreira Iván , Lorenzo-Martínez Susana , López-Delgado Ángel , Pérez-Encinas Montserrat
Published: September 2022

Background: Various authors have validated scales to measure comorbidity. However, the prognosis capacity variation according to the comorbidity measurement index used needs to be determined in order to identify which is the best predictor. Aims: To quantify the differences between the Charlson (CCI), Elixhauser (ECI) and van Walraven (WCI) comorbidity indices as prognostic factors for in-hospital mortality and to identify the best comorbidity measure predictor. Methods: A retrospective observational study that included all hospitalizations of patients over 18 years of age, discharged between 2017 and 2021 in the hospital, using the Minimum Basic Data Set (MBDS). We calculated CCI, ECI, WCI according to ICD-10 coding algorithms. The correlation and concordance between the three indices were evaluated by Spearman’s rho and Intraclass Correlation Coefficient (ICC), respectively. The logistic regression model for each index was built for predicting in-hospital mortality. Finally, we used the receiver operating characteristic (ROC) curve for comparing the performance of each index in predicting in-hospital mortality, and the Delong method was employed to test the statistical significance of differences. Results: We studied 79,425 admission episodes. The 54.29% were men. The median age was 72 years (interquartile range [IQR]: 56–80) and in-hospital mortality rate was 4.47%. The median of ECI was = 2 (IQR: 1–4), ICW was 4 (IQR: 0–12) and ICC was 1 (IQR: 0–3). The correlation was moderate: ECI vs. WCI rho = 0.645, p < 0.001; ECI vs. CCI rho = 0.721, p < 0.001; and CCI vs. WCI rho = 0.704, p < 0.001; and the concordance was fair to good: ECI vs. WCI Intraclass Correlation Coefficient type A (ICCA) = 0.675 (CI 95% 0.665–0.684) p < 0.001; ECI vs. CCI ICCA = 0.797 (CI 95% 0.780–0.812), p < 0.001; and CCI vs. WCI ICCA = 0.731 (CI 95% 0.667–0.779), p < 0.001. The multivariate regression analysis demonstrated that comorbidity increased the risk of in-hospital mortality, with differences depending on the comorbidity measurement scale: odds ratio [OR] = 2.10 (95% confidence interval [95% CI] 2.00–2.20) p > |z| < 0 using ECI; OR = 2.31 (CI 95% 2.21–2.41) p > |z| < 0 for WCI; and OR = 2.53 (CI 95% 2.40–2.67) p > |z| < 0 employing CCI. The area under the curve [AUC] = 0.714 (CI 95% 0.706–0.721) using as a predictor of in-hospital mortality CCI, AUC = 0.729 (CI 95% 0.721–0.737) for ECI and AUC = 0.750 (CI 95% 0.743–0.758) using WCI, with statistical significance (p < 0.001). Conclusion: Comorbidity plays an important role as a predictor of in-hospital mortality, with differences depending on the measurement scale used, the van Walraven comorbidity index being the best predictor of in-hospital mortality.
Voluntary Carbon Disclosure (VCD) Strategy under the Korean ETS: With the Interaction among Carbon Performance, Foreign Sales Ratio and Media Visibility
Authors: Kim Sun Ae , Kim Jong Dae
Published: September 2022

While there has been a sufficient amount of research and empirical evidence on the factors that influence a company’s decisions to voluntarily disclose carbon information, little research has been done on the carbon disclosure practices of ETS-affected companies, in Asian countries, in particular. Considering this, it is essential to shed light on more diverse linkages between carbon performance and voluntary carbon disclosure (VCD) under ETSs taking into account the specific context of each individual country. Drawing on the Korean ETS-affected companies with a contents analysis of their sustainable reports from 2015 to 2019, the present research seeks to address the existing knowledge gaps in the current literature on carbon disclosure. In doing so, hierarchical ordinary least square (OLS) regression analysis is used to infer causality and assess the findings. The findings empirically prove a positive relationship between carbon performance and VCD, which means that the affected companies under the Korean ETS are likely to disclose more when they have favorable carbon reduction performance. Furthermore, this link tends to be amplified for companies with a high percentage of foreign sales, while the role of media visibility interacts differently with carbon performance in influencing VCD.
Assessment of Enamel Color Stability of Resins Infiltration Treatment in Human Teeth: A Systematic Review
Authors: Saccucci Matteo , Corridore Denise , Di Carlo Gabriele , Bonucci Elisa , Cicciù Marco , Vozza Iole
Published: September 2022

(1) The evolution of techniques and materials used in dentistry has led to the introduction of a technique known as micro-infiltration, using ICON infiltrating resin. The purpose of this study was to evaluate whether the resin infiltrant can remain stable in the enamel color of human teeth over time or if it causes discoloration and review current knowledge on color stability based on the literature selected solely on studies performed on human teeth and to provide a perspective on the methods proposed by clinicians in the infiltration procedure; (2) Methods: This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement; (3) Results: Twelve studies were selected for this review. The study results suggest that the device content is sufficiently comprehensive. The reviewers expressed strong support for the device’s content for assessing the quality of reviews. The paper summarizes current reports regarding the color stability assessment of enamel treated by in- filtration resin confirmed in in vitro and in vivo studies; (4) Conclusions: Based on these considerations, the resin infiltration method can be recommended to improve the appearance of enamel lesions. The infiltrated lesions remained chromatically stable, showing no significant color changes in the long term.
The Prevalence of Oral Mucosa Lesions in Pediatric Patients
Authors: Owczarek-Drabińska Joanna Elżbieta , Nowak Patrycja , Zimoląg-Dydak Małgorzata , Radwan-Oczko Małgorzata
Published: September 2022

The prevalence of oral mucosa lesions (OMLs) among children varies from 4.1% up to 69.5%. There is a lack of sufficient epidemiological data and adequate knowledge about OMLs in relation to minors’ gender and age. The aim of the study was to evaluate the prevalence of OMLs in children, patients of the oral pathology clinic in south-western parts of Poland, and to investigate the potential correlation between the occurrence of particular types of OMLs and the gender and age. A retrospective study was performed using a total of 2474 clinical charts from 2015 to 2019. Data collected included age, gender, and OMLs’ type. The prevalence of OMLs in minors was 5.21%. Aphthae was the most frequent diagnosis. Boys were more commonly affected, and traumatic erosion and ulcers were significantly more often detected in males. The mean age of children was 8 y/o, preschoolers were significantly more often diagnosed with geographic tongue, while Morsicatio buccarum was significantly more common in school children and adolescents. Clinicians should be familiar with OMLs prevalence and with its specific frequency in connection to age and gender of children. Furthermore, they should be aware of the diversity of OMLs found in the oral cavity of children and that their frequency in the pediatric population is different from that in adults.
The Impact of the Green Credit Policy on the Short-Term and Long-Term Debt Financing of Heavily Polluting Enterprises: Based on PSM-DID Method
Authors: Yang Yan , Zhang Yingli
Published: September 2022

“Green economy and sustainable development” has become the focus of contemporary world economic development. As an important part of green financial instruments, green credit has become a hot topic. This paper investigates whether the Green Credit Policy has had any impact. Does it have a binding effect on the debt financing of heavily polluting enterprises? Using the Green Credit Guidelines as the starting point for the implementation of the Green Credit Policy, this paper takes Chinese A-share listed enterprises from 2004 to 2020 as the research sample, and applies the propensity score matching combined with difference-in-difference (PSM-DID) method to analyze the impact of green credit policies on the long- and short-term financing scale of heavily polluting enterprises. The study found that the implementation of the Green Credit Policy significantly suppressed the long-term financing of heavily polluting enterprises, but allowed for the expansion of short-term financing for heavily polluting enterprises. Compared with the state-owned enterprises, the Green Credit Policy has a more significant impact on non-state-owned enterprises in terms of suppressing long-term financing and increasing short-term financing, suggesting that the Green Credit Policy is affected by the “credit discrimination” of non-state-owned enterprises. Therefore, the Green Credit Policy still needs to be improved. This study provides empirical evidence of the effectiveness of green credit policies in China, and offers suggestions for further green credit policies in the future.
Multimodal Diabetes Empowerment for Older Adults with Diabetes
Authors: Park Keumok , Song Youngshin
Published: September 2022

Systematically improving empowerment is not easy when operating a diabetes program for older adults. This study aimed to develop and test the feasibility of the diabetes empowerment (Dia-Empower) program for older adults with type 2 diabetes. A non-randomized controlled study with a matched sampling design was conducted. Community-dwelling older adults with diabetes were allocated to either the Dia-Empower program group or a control group. Changes in the primary (diabetes self-care and empowerment) and secondary outcomes (body composition and physical function) were compared between the groups. The scores for diabetes self-care and empowerment were significantly higher in the experimental group than in the control group. Changes in skeletal muscle mass and body fat ratio were significantly different between the groups. Handgrip strength and shoulder flexibility positively changed in the experimental group. The Dia-Empower program was feasible for older adults with diabetes in the community. In the future, it is necessary to study the long-term effects of the program and its effects on blood sugar control.
Spatial-Temporal Pattern Evolution of Public Sentiment Responses to the COVID-19 Pandemic in Small Cities of China: A Case Study Based on Social Media Data Analysis
Authors: Zhou Yuye , Xu Jiangang , Yin Maosen , Zeng Jun , Ming Haolin , Wang Yiwen
Published: September 2022

The impact of the COVID-19 pandemic on public mental health has become increasingly prominent. Therefore, it is of great value to study the spatial-temporal characteristics of public sentiment responses to COVID-19 exposure to improve urban anti-pandemic decision-making and public health resilience. However, the majority of recent studies have focused on the macro scale or large cities, and there is a relative lack of adequate research on the small-city scale in China. To address this lack of research, we conducted a case study of Shaoxing city, proposed a spatial-based pandemic-cognition-sentiment (PCS) conceptual model, and collected microblog check-in data and information on the spatial-temporal trajectory of cases before and after a wave of the COVID-19 pandemic. The natural language algorithm of dictionary-based sentiment analysis (DSA) was used to calculate public sentiment strength. Additionally, local Moran’s I, kernel-density analysis, Getis-Ord Gi* and standard deviation ellipse methods were applied to analyze the nonlinear evolution and clustering characteristics of public sentiment spatial-temporal patterns at the small-city scale concerning the pandemic. The results reveal that (1) the characteristics of pandemic spread show contagion diffusion at the micro level and hierarchical diffusion at the macro level, (2) the pandemic has a depressive effect on public sentiment in the center of the outbreak, and (3) the pandemic has a nonlinear gradient negative impact on mood in the surrounding areas. These findings could help propose targeted pandemic prevention policies applying spatial intervention to improve residents’ mental health resilience in response to future pandemics.
How Are Sociodemographic, Health, Psychological, and Cognitive Factors Associated with Dementia Worry? An Online Survey Study among Israeli and Australian Laypeople
Authors: Werner Perla , Kim Sarang
Published: September 2022

Background: Dementia worry is a widespread phenomenon and the most common emotional reaction elicited by the threat of developing dementia in the future. The cultural factors of dementia worry have not been examined widely, although dementia can be perceived differently between cultures and lead to varying levels of dementia worry. The purpose of this study was to examine the level of dementia worry and factors associated with it cross-nationally in Israel and Australia. Methods: A cross-sectional, online survey was conducted with two age-matched adult samples (447 participants in Israel and 290 in Australia). The primary outcome measure was the 12-item Dementia Worry Scale. Results: Israeli participants (mean age = 42.5 years; 50.1% female) reported statistically significantly (p < 0.05) higher levels of concern about developing dementia in comparison to Australian participants (mean age = 43.7 years; 49.8% female). Increased ageism and increased perceptions about the likelihood of developing dementia were the most important factors associated with increased worry. Conclusions: Our findings suggest that country may not be the best criterion to assess cultural differences and should be accompanied by the participants’ assessment of their cultural tendencies. Our study also stresses the importance of conceptualizing and assessing affective and cognitive aspects of dementia worry, as people from different cultures might perceive dementia worry cognitively differently but affectively similar and vice-versa.
Storyboarding HIV Infected Young People’s Adherence to Antiretroviral Therapy in Lower- to Upper Middle-Income Countries: A New-Materialist Qualitative Evidence Synthesis
Authors: Hendricks Lynn A. , Young Taryn , Van Wyk Susanna S. , Matheï Catharina , Hannes Karin
Published: September 2022

Young people living with perinatal infections of Human Immunodeficiency Virus (YLPHIV) face a chronic disease, with treatment including adherence to lifelong antiretroviral treatment (ART). The aim of this QES was to explore adherence to ART for YLPHIV as an assemblage within the framework of the biopsychosocial model with a new materialist perspective. We searched up to November 2021 and followed the ENTREQ and Cochrane guidelines for QES. All screening, data extraction, and critical appraisal were done in duplicate. We analysed and interpreted the findings innovatively by creating images of meaning, a storyboard, and storylines. We then reported the findings in a first-person narrative story. We included 47 studies and identified 9 storylines. We found that treatment adherence has less to do with humans’ preferences, motivations, needs, and dispositions and more to do with how bodies, viruses, things, ideas, institutions, environments, social processes, and social structures assemble. This QES highlights that adherence to ART for YLPHIV is a multisensorial experience in a multi-agentic world. Future research into rethinking the linear and casual inferences we are accustomed to in evidence-based health care is needed if we are to adopt multidisciplinary approaches to address pressing issues such as adherence to ART.
Volatile Dimethyl Disulfide from Guava Plants Regulate Developmental Performance of Asian Citrus Psyllid through Activation of Defense Responses in Neighboring Orange Plants
Authors: Ling Siquan , Qiu Hualong , Xu Jinzhu , Gu Yanping , Yu Jinxin , Wang Wei , Liu Jiali , Zeng Xinnian
Published: September 2022

Intercropping with guava (Psidium guajava L.) can assist with the management of Asian citrus psyllid (ACP, Diaphorina citri Kuwayama), the insect vector of the huanglongbing pathogen, in citrus orchards. Sulfur volatiles have a repellent activity and physiological effects, as well as being important components of guava volatiles. In this study, we tested whether the sulfur volatiles emitted by guava plants play a role in plant–plant communications and trigger anti-herbivore activities against ACP in sweet orange plants (Citrus sinensis L. Osbeck). Real-time determination using a proton-transfer-reaction mass spectrometer (PTR-MS) showed that guava plants continuously release methanethiol, dimethyl sulfide (DMS), and dimethyl disulfide (DMDS), and the contents increased rapidly after mechanical damage. The exposure of orange plants to DMDS resulted in the suppression of the developmental performance of ACP. The differential elevation of salicylic acid (SA) levels; the expression of phenylalanine ammonia lyase (PAL), salicylate-O-methyl transferase (SMT), and pathogenesis-related (PR1) genes; the activities of defense-related enzymes PAL, polyphenol oxidase (PPO), and peroxidase (POD); and the total polyphenol content were observed in DMDS-exposed orange plants. The emission of volatiles including myrcene, nonanal, decanal, and methyl salicylate (MeSA) was increased. In addition, phenylpropanoid and flavonoid biosynthesis, and aromatic amino acid (such as phenylalanine, tyrosine, and tryptophan) metabolic pathways were induced. Altogether, our results indicated that DMDS from guava plants can activate defense responses in eavesdropping orange plants and boost their herbivore resistance to ACP, which suggests the possibility of using DMDS as a novel approach for the management of ACP in citrus orchards.
Obstructive Sleep Apnea Syndrome In Vitro Model: Controlled Intermittent Hypoxia Stimulation of Human Stem Cells-Derived Cardiomyocytes
Authors: Regev Danielle , Etzion Sharon , Haddad Hen , Gopas Jacob , Goldbart Aviv
Published: September 2022

Cardiovascular morbidity is the leading cause of death of obstructive sleep apnea (OSA) syndrome patients. Nocturnal airway obstruction is associated with intermittent hypoxia (IH). In our previous work with cell lines, incubation with sera from OSA patients induced changes in cell morphology, NF-κB activation and decreased viability. A decrease in beating rate, contraction amplitude and a reduction in intracellular calcium signaling was also observed in human cardiomyocytes differentiated from human embryonic stem cells (hESC-CMs). We expanded these observations using a new controlled IH in vitro system on beating hESC-CMs. The Oxy-Cycler system was programed to generate IH cycles. Following IH, we detected the activation of Hif-1α as an indicator of hypoxia and nuclear NF-κB p65 and p50 subunits, representing pro-inflammatory activity. We also detected the secretion of inflammatory cytokines, such as MIF, PAI-1, MCP-1 and CXCL1, and demonstrated a decrease in beating rate of hESC-CMs following IH. IH induces the co-activation of inflammatory features together with cardiomyocyte alterations which are consistent with myocardial damage in OSA. This study provides an innovative approach for in vitro studies of OSA cardiovascular morbidity and supports the search for new pharmacological agents and molecular targets to improve diagnosis and treatment of patients.
Analysis of Microorganism Colonization, Biofilm Production, and Antibacterial Susceptibility in Recurrent Tonsillitis and Peritonsillar Abscess Patients
Authors: Klagisa Renata , Racenis Karlis , Broks Renars , Balode Arta Olga , Kise Ligija , Kroica Juta
Published: September 2022

Background: Despite the widespread use of antibiotics to treat infected tonsils, episodes of tonsillitis tend to recur and turn into recurrent tonsillitis (RT) or are complicated by peritonsillar abscesses (PTAs). The treatment of RT and PTAs remains surgical, and tonsillectomies are still relevant. Materials and methods: In a prospective, controlled study, we analyzed the bacteria of the tonsillar crypts of 99 patients with RT and 29 patients with a PTA. We performed the biofilm formation and antibacterial susceptibility testing of strains isolated from study patients. We compared the results obtained between patient groups with the aim to identify any differences that may contribute to ongoing symptoms of RT or that may play a role in developing PTAs. Results: The greatest diversity of microorganisms was found in patients with RT. Gram-positive bacteria were predominant in both groups. Candida species were predominant in patients with a PTA (48.3% of cases). Irrespective of patient group, the most commonly isolated pathogenic bacterium was S. aureus (in 33.3% of RT cases and in 24.14% of PTA cases). The most prevalent Gram-negative bacterium was K. pneumoniae (in 10.1% of RT cases and in 13.4% of PTA cases). At least one biofilm-producing strain was found in 37.4% of RT cases and in 27.6% of PTA cases. Moderate or strong biofilm producers were detected in 16 out of 37 cases of RT and in 2 out of 8 PTA cases. There was a statistically significant association found between the presence of Gram-positive bacteria and a biofilm-formation phenotype in the RT group and PTA group (Pearson χ2 test, p < 0.001). S. aureus and K. pneumoniae strains were sensitive to commonly used antibiotics. One S. aureus isolate was identified as MRSA. Conclusions: S. aureus is the most common pathogen isolated from patients with RT, and Candida spp. are the most common pathogens isolated from patients with a PTA. S. aureus isolates are susceptible to most antibiotics. Patients with RT more commonly have biofilm-producing strains, but patients with a PTA more commonly have biofilm non-producer strains. K. pneumoniae does not play a major role in biofilm production.
Novel Splicing Mutation in MTM1 Leading to Two Abnormal Transcripts Causes Severe Myotubular Myopathy
Authors: Bosco Luca , Leone Daniela , Costa Comellas Laura , Monforte Mauro , Pane Marika , Mercuri Eugenio , Bertini Enrico , D’Amico Adele , Fattori Fabiana
Published: September 2022

X-linked myotubular myopathy (XLMTM) is a severe form of centronuclear myopathy, characterized by generalized weakness and respiratory insufficiency, associated with pathogenic variants in the MTM1 gene. NGS targeted sequencing on the DNA of a three-month-old child affected by XLMTM identified the novel hemizygous MTM1 c.1261-5T>G intronic variant, which interferes with the normal splicing process, generating two different abnormal transcripts simultaneously expressed in the patient’s muscular cells. The first aberrant transcript, induced by the activation of a cryptic splice site in intron 11, includes four intronic nucleotides upstream of exon 12, resulting in a shift in the transcript reading frame and introducing a new premature stop codon in the catalytic domain of the protein (p.Arg421SerfsTer7). The second aberrant MTM1 transcript, due to the lack of recognition of the 3′ acceptor splice site of intron 11 from the spliceosome complex, leads to the complete skipping of exon 12. We expanded the genotypic spectrum of XLMTM underlying the importance of intron–exons boundaries sequencing in male patients affected by XLMTM.
Identification of the Key Functional Domains of Bombyx mori Nucleopolyhedrovirus IE1 Protein
Authors: Hu Zhi-Gang , Dong Zhan-Qi , Miao Jiang-Hao , Li Ke-Jie , Wang Jie , Chen Peng , Lu Cheng , Pan Min-Hui
Published: September 2022

The immediate early protein 1 (IE1) acts as a transcriptional activator and is essential for viral gene transcription and viral DNA replication. However, the key regulatory domains of IE1 remain poorly understood. Here, we analyzed the sequence characteristics of Bombyx mori nucleopolyhedrovirus (BmNPV) IE1 and identified the key functional domains of BmNPV IE1 by stepwise truncation. Our results showed that BmNPV IE1 was highly similar to Autographa californica nucleopolyhedrovirus (AcMNPV) IE1, but was less conserved with IE1 of other baculoviruses, the C-terminus of IE1 was more conserved than the N-terminus, and BmNPV IE1 was also necessary for BmNPV proliferation. Moreover, we found that IE1158–208 was a major nuclear localization element, and IE11–157 and IE1539–559 were minor nuclear localization elements, but the combination of these two minor elements was equally sufficient to fully mediate the nuclear entry of IE1. Meanwhile, IE11–258, IE1560–584, and the association of amino acids 258 and 259 were indispensable for the transactivation activity of BmNPV IE1. These results systematically resolve the functional domains of BmNPV IE1, which contribute to the understanding of the mechanism of baculovirus infection and provide a possibility to synthesize a small molecule IE1-truncated mutant as an agonist or antagonist.