bluuebunny/crossref_metadata_2025 huggingface dataset:
Free and paid software on Architecture and Urbanism: Essential tools for the contemporary professional activity
Authors: Francisco dos Santos Neto Alber , Dias Venâncio Gabriel
Published: September 2021

Nowadays, the architect and urban planner’s professional have their professional practices intrinsically tied to the use of computers and software. Besides the acquisition of hardware, the prices of these softwares are a barrier for many professionals that are just now entering the job market, who end up using them by improper means -violating intellectual property laws. Such practice incurs illegal activity and creates distortions in market prices practiced by professionals. That’s why there is a need to study architects’ and urban planners’ workflow to formalize guidelines as to the possibilities of free and paid software. To do so, it’s pursued to creating an infographic about the workflow of architects and the free and paid software that can e used. It’s about raising awareness of the legal aspects of the professional activity, bringing recommendations for the academic environment, and enhancing the role of the architect and urban planner
Restorative justice and the resolution of judicial conflicts: na analysis of the restorative justice Program of the General Department of Social and Education Actions (DEGASE –RJ)
Authors: Vitória Abrahão Cabral Marina , Júnio dos Santos Valdir
Published: September 2021

The analytical and practical field of restorative justice is linked to the debates on the new social conflict management that challenge the institutional design of criminal justice and the Brazilian legal system. When starting from the problematization of the Brazilian criminal justice, we assume that the penalty under neoliberalism presents itself as a societal project that is sustained by the paradox of the potentiation of the police and penitentiary State and the minimization of the economic and social areas of action of the State. Thus, restorative justice emerges as an efficient conflict resolution mechanism, mainly because its criminal approach is based on equating relationships and repairing the damage caused to individuals and communities. In this context, this research aims at analyzing the impact of the implementation of the Restorative Justice Program of the General Department of Social and Education Actions (DEGASE, abbreviation in Portuguese) established by Ordinance 441 of September 13, 2017, within the scope of the social and education units, as well as the challenges presented to those responsible for implementing the law in the state of Rio de Janeiro, Brazil (judges, public defenders, members of the Public Prosecution Service and the DEGASE System) inthe management of restorative practices directed at juvenile offenders deprived of freedom. This problematization raises questions about the limits of the definition of crime and punishment; the relationship between criminal law; and the protection of human rights. The research is structured in three stages: systematic review of the academic field of restorative justice and the Brazilian criminal justice system; elaboration of a framework of the experiences of policies developed in the field of restorativejustice in the state of Rio de Janeiro; and the elaboration of the sociodemographic profile of adolescents and their family structure –analyzing the variables:gender, infraction, age group, monthly family income, education, family structure, and territoriality. It is expected to obtain a critical view of the state of the art of literature on restorative justice in the Brazilian criminal justice system and the debate in the field of conflict resolution criminalized by juvenile offenders served by the Restorative Justice Program of the General Department of Social and Education Actions (DEGASE).
istory and updates on three decades of practice and evolution of the Child and Adolescent Statute –ECA
Authors: Eduarda Paes Rodrigues Maria , Vitória Abrahão Marina , Borsoi Agrizzi de Matos Lorena
Published: September 2021

Result of a scientific initiation project (PROVIC), linked to the Law course of the educational institution ISECENSA, the study aimed to identify the lack of knowledge considered essential for the development of civil society and, given such result, provide the population with access to proposed knowledge. The Seminar took place on April 9, 2021. On the occasion, notions of rights as well as specific updates on the Statute of Children and Adolescents were shared with young people from the Teorema/UENF social entrance exam. The entiremethodology was organized and designed in such a way as to allow the updated information to reach those who, due to various circumstances, would not have access to it otherwise and, on the other hand, using the methods of the inverted classroom, we seek to provide students from the first periods of the Law course at ISECENSA, experiences so that the student could combine the theoretical material covered in the classroom with practical knowledge, teaching and guiding specific groups, through the presentation of seminars. The method chosen to carry out the project was the dialectic one, where prioritization in the construction of knowledge takes place through the relationship between the student with other students and with the world, in which teachers and students work together, reflect and develop content, making the more real and meaningful learning by developing and expanding multiple skills for everyone involved. As a method, dialectics represents reality in motion, going beyond appearances. Change becomes a possibility in the dialectical way of thinking through the overcoming of inequality in the production and distribution of the results of collective work. As a final result of the experience, the importance of disseminating updated legal information wascontacted so that we can obtain better reflections on the development of civil society
Affirmative action and justice policies: an analysis of the understanding of law course students about the legal reservation of places for access to higher education
Authors: Cavalcante de Melo Thamyres , Gomes da Silva Muylaert Monteiro de Castro Bianca
Published: September 2021

Affirmative actions reflect the ideal of achieving equal opportunities and represent the realization of cultural transformations in order to reduce the effects of historically accumulated inequalities. Such actions are capableof implementing greater representation of minority groups in the most diverse domains of public and private activity. In the case of quotas instituted to guarantee minority access to higher education, the reservation of places is one of the forms of social justice that tries to guarantee a minimum level of education for the most disadvantaged, trying to compensate and equalize the opportunities for access to education. This research aimed to analyze the perception of students in the ISECENSA Law course about the affirmative action policy, with an emphasis on the quota modality that promotes the legal reserve of places for the so-called “minorities”. Therefore, the methodology used was qualiquantitative and had as its starting point the bibliographical review to situate the quota policy as an object in the field of socio-legal studies. Documentary analysis of laws on the subject was carried out, as well as field research, through which the questionnaire was used as a data collection instrument to verify the position of ISECENSA law students on the quota policy and to identify whether the students understand the meaning of the quota policy. Thus, 115 questionnaires were applied to students from the 1st to the 5th period of the Isecensa Law course and the data collected showed the students' concern with Social Justice, even with the initial lack of knowledge about the concept of “affirmative action”. In this way, it was possible to analyze the perception of law students at ISECENSA regarding the quota policy and also to promote awareness of the reasons and effects of the implementation of that policy. It is expected then, to contribute to the humanization of educational institutions by encouraging diversity in order to build a society that respects difference, seeking to achieve peace and equality
The impacts of the Digital Age on the formation of readers in the early years of Elementary School
Authors: Estéfany Freitas Barbosa Glória , da Silva Gomes Larissa , Fernandes Coelho de Oliveira Margaret , Raquel de Souza Pourbaix Diniz Ana
Published: September 2021

The theme aboutreader formation in Brazil is recurrent in different debates throughout history, considering its importance for the construction of a literate society.This study aimed to draw the reader's profileaged 6 to 10 yearsof the literary text, making an interface with the influence of the Digital Age in the choice of textual genres (fairy tales, legends, fables, among others) and in the formats of reading adhered to by students.Therefore, we aimed to identify the different styles of reading, as well as the ideological aspects inherent to this phenomenon, based on the frequency and formats of reading, namely: on screen and on paper.As a methodology, we carried out a bibliographic survey and applied exploratory research to private school teachers, in a city in the interior of the State of Rio de Janeiro.The survey data point to the great challenge of waking up children's appetite for the universe of reading in the Digital Age. Of the interviewed teachers,most defend the importance of literary reading, however most prefer videos and movies to reading.According to the teachers' testimony, children who like to read develop more creativity and criticality. The research revealed that the option for the act ofreading in detriment to other possibilities of access to culture receives a lot of influence from the encouragement of the school and the family.The sampling highlighted the importance of the literary ambience. We hope that the studywill contribute to the thought of new strategies to encourage reading, by portraying the students' inclination towards audiovisual language
Subjectivity and media production on drug addiction
Authors: Ribeiro Siqueira Milena , Villaça Azeredo Cezar , Fonseca Braga de Melo Raphael , Rodrigues Cedro de Brito Rebecca , Henrique Ribeiro-Andrade Érica
Published: September 2021

The present study analyzes the phenomenon of drug addiction concerning how it is affected by the media and its ways of representing reality. This study aimed to identify articles about drug addiction published in information media of great national circulation, namely VEJA online Magazine, Folha de São Paulo online newspaper and Scielo Brasil website. Leading off from the hypothesis that the influence of media in society impacts the ways of coping with the issue studied. A theoretical survey was then carried out on media productions and social representations, as well as a general concept on drug addiction. The selected time criterion was of five years from January 2016 to December 2020. The research data were treated using the Content Analysis method proposed by Bardin (2011). It was possible to perceive a profile in these publications with regard to their vulnerabilities, such as the use of stigmatizing terms to refer to the drug addict. A great disproportionality between the total number of publications and the number of productions that addressed the topic of drug addiction could be observed in all three information vehicles. All three platforms demonstrated a limited view on the importance of the emotional aspects linked to drug addiction, and on the urgency of attention to the addict's support network. The power of influence that the information media has on social action could be verified. It is recommended that information sources in Brazil make better use of this provision, in addition to the knowledge acquired in Psychology for a better basis and greater range of the required problematizations
Os desafios dos cuidados paliativos na atenção primária à saúde
Authors: Ordonho Laura Comeli , Dias Isadora Correia , Bernardino Julia de Oliveira , Almeida Jullyana Lopes , Junior Lucio Mendes , Paula Mariana Martins de Mello , Quintão Marina Perigolo Barros , Miranda Nayara Lima de , Mendes Talita de Oliveira Côrtes , Corrêa Mônica Isaura
Published: September 2021

Objetivo: Revisar e descrever o papel da Atenção Primária em Saúde (APS) no manejo ao paciente em Cuidado Paliativo (CP), a partir da análise da literatura atual sobre o tema. Revisão bibliográfica:  O CP está associado à melhora da qualidade de vida de pacientes que enfrentam doenças graves e de seus familiares. Nesse contexto, a APS é vista como o melhor local para a prática do CP, uma vez que tem como objetivo o cuidado integral do paciente e sua família, a partir de uma relação mais próxima com a equipe de saúde. Entretanto, o CP ainda é um desafio para o Sistema Único de Saúde devido, principalmente, à alta demanda decorrente do envelhecimento populacional e aumento dos agravos crônicos, a não disponibilidade de recursos tecnológicos e humanos capacitados e a escassez de programas governamentais específicos. Considerações finais: É de suma importância que haja a implementação de diretrizes e protocolos de saúde voltadas para desenvolver os CP, maior capacitação profissional e estímulo para maior consciência social e envolvimento da comunidade como um todo com as questões de saúde da população.
Psychiatric comorbidities in dermatitis artefacta: A systematic review and meta-analysis
Authors: Rajkumar Ravi Philip
Published: September 2021

Dermatitis artefacta, also known as factitious or factitial dermatitis, is a rare and difficult-to-treat condition characterized by self-inflicted skin lesions. Despite the well-documented psychological disturbances that characterize this condition, little is known about the relative frequency of specific psychiatric disorders in this patient group. The current systematic review was undertaken to address this gap in our knowledge and was conducted in accordance with PRISMA guidelines. The PubMed and Scopus databases were searched using the terms “dermatitis artefacta,” “factitious dermatitis,” and “factitial dermatitis” in combination with “psychiatry,” “psychiatric diagnosis,” “psychiatric disorder,” “mental illness,” “depression,” and “anxiety.” After screening a total of 215 citations, a total of 11 papers were included in the final review. All the included studies were of low to very low quality as per the GRADE guidelines, and there was substantial heterogeneity among them (I2= 50.4). It was observed that 46.2% of patients (95% CI: 35.4–57.4%) with dermatitis artefacta had a comorbid psychiatric disorder, with the most common diagnoses being depression, somatoform disorders, anxiety disorders, substance use disorder, and intellectual disability. About 20.1% of patients refused a psychiatric evaluation, while 40.9% reported a significant stressful life event. These results suggest that a significant proportion of patients with dermatitis artefacta suffer from psychiatric disorders, which may be related to their self-infliction of lesions either biologically or psychologically. Treatment of these disorders may lead to a partial or complete improvement in their dermatological condition. A sensitive, non-confrontational approach is essential when evaluating these patients to minimize the chances of refusal and improve patient compliance.
Supercoiling Theory and Model of Chromosomal Structures in Eukaryotic Cells
Authors: Zhang Hao , Li Tianhu
Published: September 2021

About six billion base pairs of DNA reside highly orderly in each human cell’s nucleus through their manifestation as twenty-three pairs of chromosomes. Delicate patterns of spatial organizations of DNA macromolecules in these eukaryotic chromosomes as well as their associated physical driving forces have, however, not been fully understood thus far. On the basis of (1) our four recent discoveries about supercoiling properties of histone H1, nucleosomes, linker DNA and polynucleosomes and (2) well-established axioms about signs, shapes and handedness of DNA supercoils, we formulate new theories and models of eukaryotic chromosomal structures. It is our conclusion that three-dimensional structures of eukaryotic chromosomes and their sublevel architectures are govern mainly by negative supercoils that are present in their naked linker DNA regions.
Supercoiling Theory and Model of Chromosomal Structures in Eukaryotic Cells
Authors: Zhang Hao , Li Tianhu
Published: September 2021

About six billion base pairs of DNA reside highly orderly in each human cell’s nucleus through their manifestation as twenty-three pairs of chromosomes. Delicate patterns of spatial organizations of DNA macromolecules in these eukaryotic chromosomes as well as their associated physical driving forces have, however, not been fully understood thus far. On the basis of (1) our four recent discoveries about supercoiling properties of histone H1, nucleosomes, linker DNA and polynucleosomes, (2) well-accepted six axioms about signs, shapes and handedness of DNA supercoils, and (3) our three new prepositions about correlations between DNA supercoils and chromosomal structures, we formulate new theories and models of eukaryotic chromosomal structures in the current report. It is our conclusion that all levels of chromosomal structures in eukaryotic cells are governed mainly by negative supercoils that are present in their naked linker DNA regions.
Influence of successful psychopharmacotherapy of anxiety-depressive spectrum disorders on the severity of chronic fatigue in patients with rheumatoid arthritis
Authors: Abramkin Anton A. , Lisitsyna Tatiana A. , Veltishchev Dmitrii Y. , Seravina Olga F. , Kovalevskaya Oksana B. , Glukhova Svetlana I. , Nasonov Evgeny L.
Published: September 2021

Aim. To assess the influence of psychopharmacotherapy (PPT) of anxiety and depressive disorders on fatigue severity in patients with rheumatoid arthritis (RA). Materials and methods. 128 RA-patients were included. Severity of fatigue was measured with fatigue severity scale (FSS), clinically important fatigue was diagnosed in patients with FSS4. Anxiety and depressive disorders (ADD) were diagnosed by a licensed psychiatrist in 123 (96.1%) of RA-patients in accordance with ICD-10 in semi-structured interview. Severity of depression and anxiety was evaluated with MontgomeryAsberg Depression Rating Scale (MADRS) and Hamilton Anxiety Rating Scale (HAM-A). RA-patients with ADD were divided into the following treatment groups: 1 сDMARDs (n=39), 2 сDMARDs+PPT (sertraline or mianserine), n=43, 3 сDMARDs+bDMARDs (n=32), 4 сDMARDs+bDMARDs+PPT (sertraline or mianserine), n=9. Biologics treatment duration varied from 1 to 5 years, antidepressants from 6 to 96 weeks. 83 (67.5%) RA patients were assessed at five-years follow-up. Multinominal logistic regression analysis was conducted to determine factors associated with clinically important fatigue. Results. Multinominal logistic regression analysis showed clinically important fatigue at baseline to be positively associated (OR 13.57; 95% CI 3.04460.486; p=0.01) and remission of ADD negatively associated (OR 0.162; 95% CI 0.0320.809; p=0.027), with clinically important fatigue at 5 years follow-up (R2=0.385, p0.0001). Conclusion. Due to significant relationship between mental health status, antidepressants treatment and clinically important fatigue in RA-patients, all patients reporting clinically important fatigue should be recommended mental health counselling by a licensed psychiatrist.
Difficulties in the diagnosis and treatment of comorbid infections with rheumatoid arthritis. Case report
Authors: Ryabkova Nadezhda L. , Marusenko Irina M. , Ryabkov Vadim A.
Published: September 2021

The article presents the case of the diagnosis of sepsis as a variant of a comorbid infection in a patient with cross syndrome (systemic lupus erythematosus and rheumatoid arthritis) on the background of the debut of coronary heart disease (acute myocardial infarction complicated by external rupture of the heart).
Review of the experience of using herbal drugs for the treatment of acute rhinosinusitis from the standpoint of evidence-based medicine
Authors:   University Hospital Ghent, Ghent, Belgium, Bachert Claus
Published: September 2021

General background. The overuse of antibiotics, including for the treatment of uncomplicated acute rhinosinusitis (ARS), has contributed to the emergence of antibiotic-resistant bacterial strains and has led to the need for alternative therapies. The review provides an assessment of the quality of evidence for the use of phytotherapy in ARS in order to determine its position among other therapies and future directions of research. The MEDLINE database was searched for randomized controlled studies of Sinupret®, Pelargonium sidoides extract (pelargonium), Cyclamen europaeum (cyclamen), cineole and GeloMyrtol®. We also searched for results from studies of a nasal spray with N-acetylcysteine and mometasone furoate (MF) in order to compare the effectiveness of herbal preparations with these traditional agents indicated for ARS. Main content. The strongest evidence was obtained for Sinupret®, followed by Pelargonium sidoides extract. Their use for treatment of ARS is supported by double-blind, placebo-controlled studies demonstrating both clinical efficacy and safety. Comparisons with traditional treatments such as topical glucocorticosteroids were found only for Sinupret® and they showed comparable efficacy, but in a small group of patients. For other herbal drugs, the pooled level of evidence was low. The search identified 2 small, placebo-controlled, randomized studies of cyclamen nasal spray. In two studies, it was impossible to make conclusions about the safety and efficacy of cyclamen nasal spray and reported no efficacy of cyclamen in reducing symptoms. We found only one randomized placebo-controlled study of GeloMyrtol® and cineol. The mention studies have showed a reduction in ARS symptoms with these two drugs, but larger studies are needed to confirm these findings. There are few studies that directly compared herbal drugs. In one randomized study, cineol was compared with Sinupret®, but the results need to be confirmed in further studies. Studies of N-acetylcysteine are limited to small clinical trials, while the use of MF nasal spray has been confirmed with results comparable in evidence to Sinupret® for the respective indications. Conclusions. There are modern studies that demonstrate the efficacy and safety of herbal drugs for ARS treatment. Given that the evidence for Sinupret® is the strongest and comparable to that for the widely available topical corticosteroid, MF, Sinupret could be considered for the treatment of uncomplicated ARS.
Extracellular traps as an important part of the pathogenesis in chronic rhinosinusitis
Authors:   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia, Svistushkin Valery M. , Nikiforova Galina N. ,   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia, Vorobyeva Nina V. ,   Lomonosov Moscow State University, Moscow, Russia, Dekhanov Artem S. ,   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
Published: September 2021

Chronic rhinosinusitis is one of the most common diseases in the structure of ENT pathology. A combination of several factors often leads to the chronicity of this disease, which significantly complicates the choice of treatment tactics while maintaining persistent inflammation in the mucous membrane of the nasal cavity and paranasal sinuses. The emergence of new data on changes occurring at the cellular-molecular level significantly affects the understanding of the processes occurring during the pathogenesis of chronic rhinosinusitis and other diseases of the ENT organs. In recent years, more and more information has been accumulating on the role of neutrophils and eosinophils, as well as on such an immune response mechanism as the formation of extracellular traps in the structure of diseases of the upper and lower respiratory tract. The review presents current information on the effect of neutrophilic and eosinophilic extracellular traps on the chronic inflammatory process in the mucous membrane of the respiratory tract using the example of chronic rhinosinusitis.
Smoking effect in patients following benign laryngeal lesions excision
Authors:   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia, Rakunova Ekaterina B. , Starostina Svetlana V. ,   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia, Svistushkin Valery M. ,   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
Published: September 2021

Background. Patients with benign laryngeal lesions usually complain on hoarseness, increased vocal effort, fatigue, stain, and if the lesion is large enough, a feeling of dyspnea with phonation. These symptoms considerably deteriorate the quality of life of the patients especially voice professionals. Aim. To optimize the treatment of patients with benign laryngeal lesions. Materials and methods. In the ENT Department of Sechenov First Moscow State Medical University (Sechenov University) a total of 90 patients presented with BLL were studied. All patients underwent microlaryngoscopy under general anesthesia and were divided into 3 groups depending on the surgical method that has been used: ʺcold-steelʺ instruments (n=30), radiofrequency ablation (n=30) and semiconductor laser (n=30) with wavelength of 1.94 mkm. Patients of each group were divided into smokers and non-smoking persons. We assessed preoperative and postoperative fibrolaryngoscopy during 6 month follow up period. Results. Earlier involution of postoperative reactive inflammation of vocal cord tissue (in 7 days after surgery) was observed in group 3, comparing with 14 days and longer period in group 1 and group 2 (p<0.0001). Reactive tissue inflammation was significantly higher in all smokers comparing to non-smoking patients (p<0.0001). Conclusion. The data we have obtained provide the basis for choosing semiconductor laser as a better surgical instrument while performing phonosurgical procedures. The proposed surgical technique makes it possible to reduce the recovery period in patients with benign laryngeal lesions. At the same time, it is important to recommend to quit smoking for the patients undergoing phonosurgery.
Relationship between the state of the lymphoid-pharyngeal ring and xerostomia syndrome
Authors:   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia, Morozova Svetlana V. , Pawlushina Ekaterina M. ,   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
Published: September 2021

Xerostomia is a condition that develops with a decrease in saliva secretion (hyposialia) or cessation of saliva secretion (asialia) and is characterized by dryness in the oral cavity. Xerostomia is widespread in different age groups, but is most common in older age groups. In a number of diseases, for example, in Sjogren's disease, xerostomia is the leading symptom complex and determines the severity of the clinical picture. Chronic inflammatory diseases of the pharynx, such as chronic tonsillitis and chronic pharyngitis, may be accompanied by a pronounced decrease in saliva secretion. Timely conservative treatment of inflammatory diseases of the pharynx has a positive effect on the dynamics of the course of xerostomia. To diagnose this condition, patients are advised to undergo sialometry. Xerostomia can be observed in the long term after bilateral tonsillectomy and, which forces patients to seek medical help. To eliminate dryness in the oral cavity after otorhinolaryngological interventions, in particular after bilateral tonsillectomy, saliva substitutes are widely used in practical otorhinolaryngology. Data on the relationship between the state of the lymphoid-pharyngeal ring and xerostomia syndrome are presented in the modern literature by single publications, and therefore, studies of the relationship between inflammatory diseases of the pharynx and the level of saliva secretion are certainly of significant scientific and practical interest. Treatment of patients suffering from both subjective and objective xerostomia requires an interdisciplinary approach with the participation of a dentist, otorhinolaryngologist and doctors of other specialties (gerantologist, endocrinologist, rheumatologist, psychotherapist). Modern methods of surgical treatment of patients with chronic tonsillitis and xerostomia using radio wave methods, highenergy laser radiation, coblator should be considered as an alternative to classical bilateral tonsillectomy.
The relevance of the situational use of nasal decongestants in modern clinical practice
Authors:   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia, Morozova Svetlana V. , Keda Lina A. ,   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
Published: September 2021

Nasal decongestants (ND) are representatives of the pharmacological group of α-adrenomimetics and are widely used in clinical practice. These drugs are successfully used as symptomatic therapy of acute rhinosinusitis (AR), as well as as part of the complex therapy of acute otitis during unloading therapy for the auditory tube. The use of ND is necessary before conducting an endoscopic examination of the nasal cavity, for a better assessment of the state of the ostiomeatal complex, the olfactory cleft, as well as differential diagnosis of various forms of rhinitis and dysosmia. ND are indispensable in the prevention of complications of AR, such as acute eustachiitis, exudative otitis media and acute otitis media. Also, these drugs are used in the prevention of the development of aerotitis and ear barotrauma. The most commonly used nasal medications of medium and long duration of action, such as xylometazoline and oxymetazoline. This article presents clinical studies demonstrating the high efficacy and safety of these drugs as part of the treatment of AR. It is shown that oxymetazoline and xylometazoline are well tolerated by patients with a minimum number of adverse events. Modern representatives of ND are such drugs as Otrivin express 0.05% with the aroma of menthol, the main active ingredient of which is oxymetazoline, Otrivin 0.1% Moisturizing formula and Otrivin 0.1% with menthol and eucalyptus, which includes xylometazoline as the main active ingredient. These drugs have confirmed their effectiveness and safety in a large number of clinical studies and can be recommended as local vasoconstrictors.
Gradual compaction of the central spindle decreases its dynamicity in PRC1 and EB1 gene-edited cells
Authors: Asthana Jayant , Cade Nicholas I , Normanno Davide , Lim Wei Ming , Surrey Thomas
Published: September 2021

During mitosis, the spindle undergoes morphological and dynamic changes. It reorganizes at the onset of the anaphase when the antiparallel bundler PRC1 accumulates and recruits central spindle proteins to the midzone. Little is known about how the dynamic properties of the central spindle change during its morphological changes in human cells. Using gene editing, we generated human cells that express from their endogenous locus fluorescent PRC1 and EB1 to quantify their native spindle distribution and binding/unbinding turnover. EB1 plus end tracking revealed a general slowdown of microtubule growth, whereas PRC1, similar to its yeast orthologue Ase1, binds increasingly strongly to compacting antiparallel microtubule overlaps. KIF4A and CLASP1 bind more dynamically to the central spindle, but also show slowing down turnover. These results show that the central spindle gradually becomes more stable during mitosis, in agreement with a recent “bundling, sliding, and compaction” model of antiparallel midzone bundle formation in the central spindle during late mitosis.
Fragmentation Typology of Sumatran Tropical Lowland Forest, Labuhanbatu Selatan - Indonesia
Authors: Samsuri Samsuri , Sitorus Febrianti , Anita Zaitunah Anita , Ahmad Alfan Gunawan
Published: September 2021

Forest land cover experienced changes caused by various factors. Deforestation and forest degradation decreased forest structure and size that produce forest fragmentation. This study aimed to determine spatial distribution patterns and typology of forest fragmentation in the Labuhanbatu Selatan district. The study uses land cover image analysis, forest fragmentation analysis, correlation analysis, and typology analysis. Forest fragmentation is determined based on patch area (CA), patch density (PD), contiguity index (CONTIG), and proximity index (PROX). The study analyzes the correlation between variable factors and the degrees of forest fragmentation to develop a typology of fragmentation forest. The variables used to construct the typology of forest fragmentation are population density, productive age ratio, income, and slope. The classification of forest fragmentation has been completed to create a forest fragmentation typology. To determine the typology of forest fragmentation, the K-Means Cluster analysis method is used. Typology of forests fragmentation of Labuhanbatu Selatan district is three typologies. Typology 1 is the low forest fragmentation of Torgamba, Silangkitang, and Kota Pinang sub-district, typology 2 is moderate forest fragmentation are the Kampung Rakyat, and Typology 3 is high forest fragmentation of Sungai Kanan sub-district.
A Persistent Blindness: A Post-Curation National Museum
Authors:   , Mcknight George
Published: September 2021

Since the industrial revolution, technology has had a defining role in society. From the built environment to domestic needs, technology has increasingly automated the world; the world has become immersed and increasingly in service to these advancements. However, in a world saturated in technology, the real-world still matters; a persistent blindnessto social, discriminatory and racial matters is still heavily ingrained and needs addressing.

This thesis is an investigation of the current machine age - a development of the First and Second Machine ages described by Banham, then Pawley, in the second half of last century. Today's 'Third Machine Age' is less mechanical - our machines are commercial, silent, and out-of-sight algorithms that use our own personal data as fuel: for the convenience of social media, we blindly provide our identities as grist to this mill.

But there are also opportunities for a socially-engaged architecture in this digitally saturated and persistently blind Third Machine Age. This research explores the idea of a national museum for the twenty-first century (with its Third Machine Age implications), offering an alternative to the singular, authoritative (colonial) interpretation of national identity and it’s curation in static ('iconic') built form. The objective is a nimble, critically-engaged, digitally augmented and ephemeral place-based intervention that foregrounds multiple and competing cultural and personal histories.

In an age where the idea of 'place' is being challenged by the architectures of 'non-place' and physical experience is increasingly supplanted by virtual engagement, it is difficult for architecture to remain relevant. This thesis is a provocative statement of one such way that architects can take a stand and make socially meaningful contributions to the Third Machine Age.
Assessment of The Difficulty of Mathematics High-Level Reasoning Using Focus Group Discussion and Program Item Approaches
Authors: Rukli Rukli , Ma'rup Ma'rup
Published: September 2021

This study aims to estimate the difficulty level of high-level reasoning math problems by comparing the estimated difficulty level of the Focus Group Discussion (FGD) approach and the Iteman program. The estimation of the FGD approach uses a semantic differential scale on a scale of 1-7, while the Iteman program uses version 4.0. The study used a quantitative-comparative approach involving 79 FGDs of students and teachers of SMP/MTs in Soppeng Regency. Each FGD consisted of four people, one teacher and three students of class VIII. The comparative of difficulty level using Scheffe test with a significance level of 0.05. The results showed that the average level of difficulty in the FGD approach had significant similarity with the average level of difficulty in the output of the Iteman program approach. This means that the estimated level of difficulty of the FGD examinees has a similarity with the output of the Iteman program from the response data of the FGD examinees. This shows that examinees  from FGD in assessing the level of difficulty of high-level reasoning questions can be the teacher’s choice in schools other than the Iteman program.
Yükseköğretim Kurumlarının Sürdürülebilir Rekabet Avantajı Elde Edebilmelerinde İlişkisel Pazarlamanın Rolü: Kaynak Avantajı Teorisi Bağlamında Nicel Bir İnceleme
Authors: ŞAHİN Fatih , TAŞKIN Ercan
Published: September 2021

Bu araştırmanın amacı güncel gelişmeler kapsamında yükseköğretim kurumlarının pazarlama faaliyetlerine yönelik ihtiyaçlarını ortaya koymak ve kaynak avantajı teorisi kapsamında iş birliklerinin başarısına ve yükseköğretim kurum performansına etki eden faktörleri yetkinlik temelli, kaynak temelli ve ilişkisel pazarlama bütünleşik modeli ile incelemektir. Yükseköğretim kurumlarının iş birliği başarısı ve kurum performansları üzerindeki etkisi olan faktörler kaynak avantajı teorisinin öne sürdüğü bütünleşik model kullanılarak "Bölgesel Kalkınma Odaklı İhtisaslaşma" projesi kapsamında yer alan kurumlardan birisi olan Uşak Üniversitesi özelinde incelenmiştir. Araştırmada kullanılan veriler Uşak Üniversitesi'nde çalışmakta olan toplam 513 akademik ve idari personelden elde edilmiştir. Araştırmanın varsayımlarının analizinde yapısal eşitlik modellemesi kullanılmıştır. Elde edilen bulgulara göre uzun dönemli ilişkiler kapsamında oluşturulan iş birlikleri, ortaklık yetkinlikleri ve özgün kaynakların rekabette konum avantajı elde edebilmede önemli bir rolü olduğu sonucuna ulaşılmıştır.
Економічна оцінка Черемського болота на основі екосистемних послуг
Authors: Andreieva Valentyna , Voitiuk Vasyl , Kychyliuk Oleksandr , Shepeliuk Mariia , Hetmanchuk Anatolii , Derkach Vitalii
Published: September 2021

Унікальністю Черемського природного заповідника є не тільки збереження рідкісних і типо-вих природних комплексів Українського Полісся, але й те, що його територія входить до складу водно-боло-тного угіддя міжнародного значення «Заплава р. Стоходу», яке, згідно з критеріями Рамсарської конвенції, має велику цінність. Оскільки із загальної площі Черемського природного заповідника болота займають 33,7% території, актуальним є вивчення їх екосистемного значення. Методика інтегральної вартісної оцінки екосистемних послуг базується на теорії екологічної ренти і механізмі її вираження – альтернативної вартості з урахуванням ефективності відтворення в економічній та екологічній сферах. Поелементна вартісна оцінка екосистемних послуг заснована на оцінці величини депо-нування вуглекислоти лісовими й природними болотними екологічними системами, сорбційної функції боліт, асиміляційного потенціалу лісових екологічних систем. Представлені результати апробації методики варті-сної оцінки екосистемних послуг Черемського болота у Черемському природному заповіднику. Показано, що Черемське болото забезпечує виконання екосистемних послуг на суму 3696003 грн/рік, а також сорбційну (водоочисну) функцію на суму 11560951 грн/рік та поглинання діоксиду вуглецю на суму 244048 грн/рік.
Список лікарських рослин ботанічного заказника «Воротнів»
Authors: Kuzmishyna Iryna , Voytiuk Vasyl , Volgin Serhiy , Dyakiv Svitlana , Kormosh Natalia
Published: September 2021

Збільшення антропогенного навантаження на довкілля, нерегульовані збір і заготівля лікарської сировини призводять до зростання значення природно-заповідних територій, сприяючи збереженню флоро-фонду. На сучасному етапі спостерігають тенденцію до розширення переліку лікарських рослин та сировини як альтернативних засобів для лікування та профілактики багатьох захворювань за рахунок відкриття нових власти-востей, а отже, внесення до списку нових видів рослин. Тому виявлення місцезростань лікарських рослин під час проведення інвентаризації флори резерватів і зумовило актуальність теми дослідження. Збереженню флори сприяє створення природно-заповідних територій, однією з яких у межах Волинської області (Україна) є ботанічний заказник загальнодержавного значення «Воротнів». Метою роботи було вивчення судинних рослин із лікувальними властивостями природної флори резервату «Воротнів», сировина з яких вико-ристовується чи може бути використана в медицині, завдання – скласти список лікарських рослин природної флори урочища та виявити види, що підлягають охороні. Основний список складено за монографічним виданням В. М. Мінарченко. Флору урочища вивчали автори загальноприйнятими геоботанічними методами впродовж 20 років. На вказаній території виявлено та вперше представлено список із 281 виду судинних рослин з лікувальними властивостями (92,4 % від загальної кількості видів). З них система споживчої кооперації України проводить за-готівлю сировини 24 лікарських рослин (8,5 % від кількості видів у представленому списку), 60 видів рослин (21,4 %) є офіцинальними. Перебувають під загальнодержавною та місцевою охороною дев’ять видів рослин із лікувальними власти-востями (Allium ursinum L., Cypripedium calceolus L., Dactylorhiza majalis(Rchb.) P.F. Hunt & Summerh., Epipactis helleborine (L.) Crantz, Lilium martagon L., Neottia nidus-avis (L.) Rich., Platanthera bifolia (L.) Rich.; Melittis sarmatica Klok., Hepatica nobilis Mill). Сучасний стан рідкісних видів рослин, сировина з яких використовується чи може бути використана в медицині, потребує подальшого постійного моніторингу, що є основою созологічного менеджме-нту.
La insustentabilidad en las áreas marginales de México: Policías comunitarias y grupos de autodefensa
Authors: Monroy Ojeda Carla
Published: September 2021

La historia de México, sobre todo con la imposición de las políticas neoliberales, ha dejado en evidencia cómo el Estado, ha permitido la exclusión y el abandono a la ciudadanía, sobre todo este México rural. Y de manera paralela, ante una desigualdad social y económica, pareciera que, en consecuencia, se vive una fuerte carencia del Estado de Derecho.

Ante esta situación de olvido, los habitantes han tenido que ver diferentes formas de organización, por ejemplo, en las zonas rurales e indígenas han decidido armarse para protegerse de la creciente delincuencia común y organizada. Al menos en la región de La Montaña de Guerrero, ya tienen más de 2 décadas que conformaron su policía comunitaria; los grupos de autodefensa presentes en 10 estados más han ido tomando presencia casi de forma paralela a la creciente violencia relacionada con la delincuencia organizada.

Los grupos de autodefensa se pueden observar como síntoma de hartazgo y que refleja el deterioro de la sustentabilidad entre el gobierno, el Estado y la ciudadanía. Por otro lado, la policía comunitaria es un sistema de justicia basada en sus usos y costumbres, fortalecida por la ineptitud y corrupción de las autoridades, ambas son formas de vida que han tomado muchas de las áreas marginales.

Es necesario conocer y difundir lo que significan estos movimientos y qué es lo que los impulsa antes de que su existencia sea criminalizada y desvirtualizada, como ocurrió en Michoacán (Tierra Caliente) en donde buscaban la paz y seguridad que no lograban tener.
Analisis Kepuasan Pengunjung Program Agroeduwisata Taman Teknologi Pertanian (TTP) Cigombong, Kabupaten Bogor
Authors: Puspita Dara , Ismail Ahyar , Burhanuddin Burhanuddin
Published: September 2021

Along with the Indonesian government project to develop science technopark, the Ministry of Agriculture of Indonesia has established Cigombong Agricultural Technopark (ATP). Agroeduwisata program is one of the Cigombong Agricultural Techno Park (ATP) programs as a tool for agricultural technology dissemination as well as become one of the business units for income-generating. To increase the number of visitors, the manager should explore the existing weaknesses and strengths to define the priorities of improvement to increase the visitor’s satisfaction. This study aims (1) to measure the satisfaction level of visitors on the Cigombong ATP agroeduwisata program, and (2) to identify the importance and performance level of the program. The research was conducted in September-October 2020 by a survey of 34 visitors to the Cigombong ATP agroeduwisata program. A descriptive analysis was developed by using the Customer Satisfaction Index (CSI) and Importance Performance Analysis (IPA). The results suggested that visitors were satisfied with a CSI value of 78.79 per cent. Furthermore, according to IPA, the improvement of the safety of location and accommodation facilities should be prioritized and further developed Meanwhile, the attributes including the benefits of agroeduwisata, the responsiveness of services, comfort of the location, politeness and friendliness. guides, ease of communication for carrying out activities, agroeduwisata activity packages offered, supporting facilities, consumption facilities and tidiness of guides were found to perform quite good and therefore should be consistently maintained. In addition, the attributes such as ticket prices, promotions, the response of complaints and access to the location were found to be less prioritized.
Strategi Bisnis PT Crowde Membangun Bangsa dengan Pendekatan Business Model Canvas (BMC)
Authors: Putri Astari Nanda , Nurmalina Rita
Published: September 2021

PT Crowde Membangun Bangsa is a financial technology company that offers capital services for agricultural activities. With the concept of peer to peer lending (P2P), the company functions as a platform are to bring investors and customers together. To continue to grow and face competition in the future, PT Crowde Membangun Bangsa requires preparation and improvement of business models. This study aims to (1) map the business model applied at PT Crowde Membangun Bangsa, (2) Identify strengths, weaknesses, opportunities, and threats of the nine elements of the Business Model Canvas based on PT Crowde Build the Nation, (3) Formulate alternative Business Model strategies The right canvas to be applied to PT Crowde Membangun Bangsa. The data collection method is carried out by direct observation and using the qualitative method. The conclusion of this study is the improvement in the new Business Model Canvas, especially in the customer segment elements by adding plantations as a new segment and beef cattle commodities as an improvement to existing segments so that the company's targets are met, improvements in these elements need to be supported by improvements in other elements. namely reactivating individual investors as additional corporate financial key resources, additional types of loan facilities to increase the value proposition, and optimizing the use of technology in customer relationship elements and key activities so that additional consumer segments are followed by maximum service and efficient key activities.
Solidariedade ou conflito
Authors: Bingemer Maria Clara Lucchetti
Published: September 2021

O presente artigo se propõe estudar as possibilidades de diálogo entre estes dois saberes a partir de dois conceitos-chave: solidariedade e conflito. Num primeiro momento, trabalharemos a maneira como estes dois conceitos aparecem respectivamente na DSI e na TdL. Num segundo momento, procuraremos ver as possibilidades concretas de diálogo entre DSI e TdL a partir da conflitividade colocada no centro do saber, como proposta da TdL e desafio à DSI. Finalmente, procuraremos demonstrar como Jesus Cristo, paradigma da DSI e conteúdo primordial da TdL, fornece a possibilidade concreta de integração entre os dois conceitos de solidariedade e conflito, ao mesmo tempo em que delimita as bases do diálogo entre DSI e TdL.