bluuebunny/crossref_metadata_2025 huggingface dataset:
Language Representation Models: An Overview
Authors: Schomacker Thorben , Tropmann-Frick Marina
Published: October 2021

In the last few decades, text mining has been used to extract knowledge from free texts. Applying neural networks and deep learning to natural language processing (NLP) tasks has led to many accomplishments for real-world language problems over the years. The developments of the last five years have resulted in techniques that have allowed for the practical application of transfer learning in NLP. The advances in the field have been substantial, and the milestone of outperforming human baseline performance based on the general language understanding evaluation has been achieved. This paper implements a targeted literature review to outline, describe, explain, and put into context the crucial techniques that helped achieve this milestone. The research presented here is a targeted review of neural language models that present vital steps towards a general language representation model.
Exact Recursive Calculation of Circulant Permanents: A Band of Different Diagonals inside a Uniform Matrix
Authors: Kocharovsky Vitaly , Kocharovsky Vladimir , Martyanov Vladimir , Tarasov Sergey
Published: October 2021

We present a finite-order system of recurrence relations for the permanent of circulant matrices containing a band of k any-value diagonals on top of a uniform matrix (for k=1,2 and 3) and the method for deriving such recurrence relations, which is based on the permanents of the matrices with defects. The proposed system of linear recurrence equations with variable coefficients provides a powerful tool for the analysis of the circulant permanents, their fast, linear-time computing; and finding their asymptotics in a large-matrix-size limit. The latter problem is an open fundamental problem. Its solution would be tremendously important for a unified analysis of a wide range of the nature’s ♯P-hard problems, including problems in the physics of many-body systems, critical phenomena, quantum computing, quantum field theory, theory of chaos, fractals, theory of graphs, number theory, combinatorics, cryptography, etc.
Chemostratigraphic Analysis of Wufeng and Longmaxi Formation in Changning, Sichuan, China: Achieved by Principal Component and Constrained Clustering Analysis
Authors: Zhang Zhifeng , Huang Yongjian , Ran Bo , Liu Wei , Li Xiang , Wang Chengshan
Published: October 2021

The increasing proportion of unconventional worldwide energy demands have consistently promoted the necessity for exploring a precise, high-resolution, objective, and quantitative stratigraphic division method for macroscopically homogeneous mudstone successions. The chemostratigraphy can resolve this problem well, although it has been applied successfully in North America, but not systematically studied in China for shale gas exploration and development. This work has conducted a chemostratigraphic analysis of Wufeng and Longmaxi Formation on the Changning section of Sichuan Province, southwestern China, to testify its applicability for shale gas exploration in China. Principal component analysis (PCA) was first employed to reduce the dimensionality of datasets. Three chemofacies, including detrital (K, Ti, Fe, Al, Na, Mg, Cr, Zr, Rb), authigenic (Ca, Sr, Mn, Si, S, Ba), and redox-organic (P, V, Ni, Zn, Cu, TOC), were found. Subsequently, constrained clustering analysis was utilized for the zonation of each chemofacies into chemozones. Consequently, the whole Changning section was divided into twelve chemozones (CZ I–CZ Ⅻ). The geochemical interpretation for these chemozones can be resolved from the regional changes in paleogeography and paleoceanography during the Late Ordovician to Early Silurian period. Thus, a three-stage geochemical evolution along the Changning section can be classified: (1) the siliceous and anoxic deposits of Wufeng Formation (CZ I–CZ III) with high TOC contents; (2) the siliceous and anoxic sedimentary rocks of bottom Longmaxi Formation with still higher TOC (CZ Ⅳ); (3) the calcarous-detrital and oxic sediments for the rest of Longmaxi Formation (CZ Ⅴ–CZ Ⅻ). In considering their high content of TOC and abundant brittle siliceous minerals, the CZ (I–Ⅳ, 0 m–33.6 m) are thought to be the most preferable sweet spot for shale gas exploration.
Updates on Evaporation and Condensation Methods for the Performance Improvement of Solar Stills
Authors: Fu He , Dai Min , Song Hanwen , Hou Xiaoting , Riaz Fahid , Li Shuai , Yang Ke , Ali Imran , Peng Changsheng , Sultan Muhammad
Published: October 2021

Solar still, a small equipment using evaporation and condensation processes to get clean water, is expected to be widely used for sea/brackish water desalination, water purification, and wastewater treatment because of its convenient carrying, friendly environment, and low energy consumption. In recent years, considerable progress has been made in improving the productivity of solar still. This paper will reclassify the methods to improve the solar still by elevating the evaporation rate and condensation rate. The main methods increasing evaporation rate are as follows: (i) adding heat storage materials; (ii) using nanoparticles; (iii) changing structure of the absorption plate; and (iv) using photothermal materials. The primary methods increasing the condensation rate are as follows: (i) cooling the condensing surface; (ii) increasing the condensation area; (iii) changing the wettability of the condensing surface; and (iv) using a separate condenser. The advantages and disadvantages of each method are compared. Furthermore, this paper includes an economic analysis of current solar stills and a forecast of future developments. The freshwater cost of solar still is in the range of about USD 0.0061–0.277/L, which provides reference and direction for future researching solar stills on their low cost and high productivity.
Study of the Radiation Flux Distribution in a Parabolic Dish Concentrator
Authors: Cisneros-Cárdenas Nidia Aracely , Cabanillas-López Rafael , Pérez-Enciso Ricardo , Martínez-Rodríguez Guillermo , García-Gutiérrez Rafael , Pérez-Rábago Carlos , Calleja-Valdez Ramiro , Riveros-Rosas David
Published: October 2021

The radiation flux distributions produced by the concentrating solar systems used to produce thermal/electrical power are usually non-homogeneous. This results in non-uniform temperature distributions on the solar receivers, causing adverse effects on the system’s overall performance. An approach to better understand the problem is to study the surfaces around the focal zone where the radiation density is homogeneous (isosurfaces), generating them from experimental data. For this, it is necessary to superimpose built volumes of the different irradiance levels using parallel planes in different directions from the focal point of a concentrator. These volumes are known as effective volumes. This study presents the model used to generate effective volume produced by a point focus concentrator, comparing it with experimental results in a direction perpendicular to the focal axis. The effective volumes were developed considering a global optical error of the system of 2.8 mrad. The set of methods used to generate effective volumes has not been previously presented in the literature. The theoretical-experimental research consisted of the combination of the camera-target method and the simulations by the ray-tracing technique. The results showed effective volumes with the highest value of 10 MW/m2 and the lowest value of 4.5 MW/m2.
Drivers of Sustainable Performance in European Energy Sector
Authors: Wieczorek-Kosmala Monika , Marquardt Dorota , Kurpanik Jarosław
Published: October 2021

The main purpose of this study is to identify the drivers of sustainable performance in firms that operate in the energy sector. Under the assumption of bidirectional impacts, we empirically tested the trade-offs between sustainable and financial performance, in light of neoclassical theory, the natural-resources-based view, and instrumental stakeholder theory. We hypothesize that, in the energy sector, sustainable performance is positively associated with firms’ financial performance and that sustainability reporting is an important driver of sustainable performance. We add primarily by considering the relevance of sustainability-policy-oriented factors and revising the role of sustainability reporting within. We provide empirical evidence based on a large panel of firm-year observations within the 2013–2020 time span, for firms that operate in the energy sector and are located in Europe. We have found strong support for the positive link between sustainable performance (proxied with ESG score) and returns, which conforms to the assumptions of the natural-resources-based view. However, we have also found some evidence that more sustainable firms face greater costs input, which is considered in neoclassical theory. We have also confirmed no relevance of the slack-resources-based view. Finally, we found sustainability reporting to be the most influential among the set of sustainability-policy-oriented factors. This evidence demonstrates that stakeholders’ pressure on firms’ transparency could be an important driver of sustainable performance in the energy sector.
Simulating the Impact of Daytime Calibration in the Behavior of a Closed Loop Proportional Lighting Control System
Authors: Tsangrassoulis Aris , Doulos Lambros , Mylonas Angelos
Published: October 2021

A daylighting control system that uses the closed loop proportional algorithm needs to be calibrated both during nighttime and daytime. The selection of the daytime calibration time can affect the behavior of the system and is usually performed when the ratio of the illuminance of the ceiling sensor (SD,tc) to the illuminance at a point on the working plane (ED,tc) is relatively large without sunlight patches in the ceiling photo-sensor’s field of view (FOV). However, this requirement is not associated with a specific value and can be achieved under a wide range of conditions related to the sky luminance distribution. In the present work, four ceiling sensors with different field of views (FOVs) were examined in a typical north-facing office space. The effect of daytime calibration on the system’s performance was estimated through the calculation of lighting energy savings and the overdimming percentage. The results show that the effect of both the FOV of the ceiling sensor and the daytime calibration period is small except for the case of the sensor without cover, especially when it is close to the opening. In an attempt to quantify the SDtc/IDtc ratio, a new magnitude (RR) is proposed by dividing the illuminance ratios of the ceiling photo-sensor by that on the working surface during daytime and nighttime calibration. Thus, the daily calibration of the sensors with cover can be performed when RR > 1.
An Experimental Performance Evaluation for a Swirl-Vane Separator Using an Air-Water Test Facility
Authors: Kim Kihwan , Kim Woo-Shik , Lee Jae-Bong
Published: October 2021

The most important design parameters of a moisture separator to optimize the efficiency of a nuclear power plant are the moisture carry over and pressure drop. An air-water test facility was constructed to evaluate the design parameters for various types of conventional moisture separators in Korea. In this study, a half scale of swirl-vane separator was designed, and test conditions were defined based on the scaling law to cover a wide range of operating conditions. The moisture carry over was measured using an isokinetic sampling system for 34 different flow conditions. The MCO was in range of 0.30–7.05% according to the test conditions. Single and two-phase flow experiments were also carried out to identify the two-phase pressure drop characteristics. Based on the obtained results, the proposed empirical correlation model was extended to a submerged separator and applying these results to a full scale system is discussed in this paper.
Introduction to the Special Issue on Longleaf Pine
Authors: Johnsen Kurt
Published: October 2021

Longleaf pine (Pinus palustris Mill [...]
Determinants of Farmers’ Intention of Straw Recycling: A Comparison Analysis Based on Different Pro-Environmental Publicity Modes
Authors: Zhu Hao , Ao Yibin , Xu Hong , Zhou Zhongli , Wang Yan , Yang Linchuan
Published: October 2021

Promoting the intention of farmers to participate in straw recycling is an effective way to alleviate the contradiction between environmental pollution, scarcity of environmental resources, and sustainable development. In this study, social trust and value perception were integrated into the theory of planned behavior to build a theoretical framework of farmers’ intention to participate in straw recycling, considering the influences of three different pro-environmental publicity modes. A field investigation was used to collect research data in six sample villages. Finally, 761 valid questionnaires were collected, and partial least squares structural equation modeling was applied to test the research hypotheses. The results showed that the influence of attitudes, subjective norms, perceived behavior control, value perception, and social trust on farmers’ straw recycling intentions was different among different pro-environmental publicity modes. Among the three pro-environmental publicity modes, the concentrated pro-environmental publicity mode has the best effect of promoting straw recycling intentions among farmers. This study introduces some targeted suggestions on the aspects of pro-environmental publicity theory and management practice based on the above research results.
Adherence to Oral Contraception in Young Women: Beliefs, Locus of Control, and Psychological Reactance
Authors: Fumero Ascensión , Marrero Rosario J. , Peñate Wenceslao , Bethencourt Juan M. , Barreiro Pedro
Published: October 2021

Background: There is a high dropout rate of oral contraceptive pills (OCP), mainly due to a lack of adherence to treatment. The aim of this study was to identify the psychological processes and attitudes toward medication involved in adherence to OCP, depending on the prescription, to avoid unintended pregnancies (AUP) or gynecological problems (GP). Methods: This cross-sectional study was conducted by asking 689 young women in the fertile period, mean age 23.41 (SD = 5.90), to complete questionnaires related to attitudes, beliefs, psychological reactance, locus of control, and adherence to contraceptive medication. Descriptive analyses and a binary logistic regression were performed. Results: The results confirmed that different beliefs and psychological processes were involved in adherence to oral contraception, based on women’s reasons for taking contraceptive medication. More psychological processes were involved in non-adherence in the AUP group than in the GP group. Psychological reactance contributed most to explaining non-adherence in women who used the OCP to prevent unintended pregnancies. Conversely, women with gynecological problems reported difficulties in adherence, mainly due to their beliefs about contraceptive pills. Conclusions: These findings indicate that attitudes toward medication and psychological processes can play an important role in adherence to OCP, including reasons for using the pill. Identifying the psychological factors and beliefs linked with contraception could guide health professionals to provide counseling to women, thus increasing their adherence to medication and maximizing their health and well-being.
Factors Associated with the Detection of Inappropriate Prescriptions in Older People: A Prospective Cohort
Authors: Molist-Brunet Núria , Sevilla-Sánchez Daniel , Puigoriol-Juvanteny Emma , Espaulella-Ferrer Mariona , Amblàs-Novellas Jordi , Espaulella-Panicot Joan
Published: October 2021

(1) Background: Ageing is associated with complex and dynamic changes leading to multimorbidity and, therefore, polypharmacy. The main objectives were to study an older community-dwelling cohort, to detect inappropriate prescriptions (IP) applying the Patient-Centred Prescription model, and to evaluate the most associated factors. (2) Methods: This was a prospective, descriptive, and observational study conducted from June 2019 to October 2020 on patients ≥ 65 years with multimorbidity who lived in the community. Demographic, clinical and pharmacological data were assessed. Variables assessed were: degree of frailty, using the Frail-VIG index; therapeutical complexity and anticholinergic and sedative burden; and the number of chronic drugs to determine polypharmacy or excessive polypharmacy. Finally, a medication review was carried out through the application of the Patient-Centred Prescription model. We used univariate and multivariate regression to identify the factors associated with IP. (3) Results: We recruited 428 patients (66.6% women; mean age 85.5, SD 7.67). A total of 50.9% of them lived in a nursing home; the mean Barthel Index was 49.93 (SD 32.14), and 73.8% of patients suffered some degree of cognitive impairment. The prevalence of frailty was 92.5%. Up to 90% of patients had at least one IP. An increase in IP prevalence was detected when the Frail-VIG index increased (p < 0.05). With the multivariate model, the relationship of polypharmacy with IP detection stands out above all. (4) Conclusions: 90% of patients presented one IP or more, and this situation can be detected through the PCP model. Factors with higher association with IP were frailty and polypharmacy.
Validation of the Korean Version of Impact of Event Scale—Revised (IES-R) in Korean Nurses during the COVID-19 Pandemic
Authors: Park Young Suk , Park Kwang-Hi , Lee Juna
Published: October 2021

Nurses working amid the COVID-19 pandemic are at increased risk of developing post-traumatic stress disorder (PTSD). This study was conducted to verify the reliability and validity of the Korean version of Impact of Event Scale—Revised (IES-R), one of the most used tools for assessing trauma. Secondary data of 249 nurses who performed face-to-face nursing tasks during the COVID-19 pandemic, collected through an online survey, were analyzed by conducting a factor analysis of the K-IES-R and testing the internal consistency and concurrent validity with the Perceived Stress Scale (PSS), Generalized Anxiety Disorder Screener (GAD-7), and Dimensions of Anger Reactions-5 (DAR-5). The result of an exploratory factor analysis of the K-IES-R supported a three-factor structure of intrusion, avoidance, and sleep disturbance, with CMIN/DF = 2.98, RMSEA = 0.09, SRMR = 0.03, CFI = 0.93, and TLI = 0.90. The Cronbach’s alpha of each subscale was 0.88–0.94. The total K-IES-R score and each factor’s value showed a significant correlation (moderate or higher) with the PSS, GAD-7, and DAR-5. The K-IES-R was verified as a useful tool for assessing post-traumatic stress symptoms in nurses who directly perform nursing tasks in crises such as COVID-19. This study suggests the tool be used for early assessment of post-traumatic stress symptoms in nurses and providing appropriate interventions.
Changes in Cultivated Land Area and Associated Soil and SOC Losses in Northeastern China: The Role of Land Use Policies
Authors: Fang Haiyan
Published: October 2021

Land use policy is the driving factor influencing land use; however, little research has been conducted to identify the role of agricultural policy in influencing land cultivation and associated soil and soil organic carbon (SOC) losses. The aims of this study were to explore temporal changes in cultivated land, soil erosion, and SOC loss and to identify the role of land use policy. The present study was conducted using the revised universal soil loss equation by integrating remote sensing images from 1980, 1990, 2000, and 2017. The study found that cultivated land areas increased from 275.11 thousand km2 in 1980, to 300.03 thousand km2 in 2000, and to 344.16 thousand km2 in 2010, and then decreased by 326.94 thousand km2. The mean soil loss rates changed from 590.66 t·km−2·yr−1 in 1980 to 634.25 t·km−2·yr−1 in 2010, and then decreased to 495.66 t·km−2·yr−1 in 2017. Soil loss rate increased with increasing slope gradient. The changes in SOC loss rates demonstrated the same pattern as that of soil loss, with the largest loss rate of 728.27 kg·km−2·yr−1. These changes can be explained by changed land use policy and population growth. In future land use management, reasonable implementation of soil conservation measures should be undertaken to reduce soil and SOC losses in the black soil region of northeastern China.
Access to Mental Health and Substance Use Resources for 2SLGBTQ+ Youth during the COVID-19 Pandemic
Authors: Chaiton Michael , Musani Iman , Pullman Mari , Logie Carmen H. , Abramovich Alex , Grace Daniel , Schwartz Robert , Baskerville Bruce
Published: October 2021

Previous research has established that gender and sexual minority (2SLGBTQ+) youth experience worse mental health and substance use outcomes than their heterosexual and cisgender counterparts. Research suggests that mental health and substance use concerns have been exacerbated by the COVID-19 pandemic. The current study used self-reported online survey responses from 1404 Canadian 2SLGBTQ+ youth which included, but were not limited to, questions regarding previous mental health experiences, diagnoses, and substance use. Additional questions assessed whether participants had expressed a need for mental health and/or substance use resources since the beginning of the COVID-19 pandemic (March 2020) and whether they had experienced barriers when accessing this care. Bivariate and multinomial logistic regression analyses were conducted to determine associations between variables and expressing a need for resources as well as experiencing barriers to accessing these resources. Bivariate analyses revealed multiple sociodemographic, mental health, and substance use variables significantly associated with both expressing a need for and experiencing barriers to care. Multinomial regression analysis revealed gender identity, sexual orientation, ethnicity, and level of educational attainment to be significantly correlated with both cases. This study supports growing research on the mental health-related harms that have been experienced during the COVID-19 pandemic and could be used to inform tailored intervention plans for the 2SLGBTQ+ youth population.
ClimApp—Integrating Personal Factors with Weather Forecasts for Individualised Warning and Guidance on Thermal Stress
Authors: Kingma B. R. M. , Steenhoff H. , Toftum J. , Daanen H. A. M. , Folkerts M. A. , Gerrett N. , Gao C. , Kuklane K. , Petersson J. , Halder A. , Zuurbier M. , Garland S. W. , Nybo L.
Published: October 2021

This paper describes the functional development of the ClimApp tool (available for free on iOS and Android devices), which combines current and 24 h weather forecasting with individual information to offer personalised guidance related to thermal exposure. Heat and cold stress assessments are based on ISO standards and thermal models where environmental settings and personal factors are integrated into the ClimApp index ranging from −4 (extremely cold) to +4 (extremely hot), while a range of −1 and +1 signifies low thermal stress. Advice for individuals or for groups is available, and the user can customise the model input according to their personal situation, including activity level, clothing, body characteristics, heat acclimatisation, indoor or outdoor situation, and geographical location. ClimApp output consists of a weather summary, a brief assessment of the thermal situation, and a thermal stress warning. Advice is provided via infographics and text depending on the user profile. ClimApp is available in 10 languages: English, Danish, Dutch, Swedish, Norwegian, Hellenic (Greek), Italian, German, Spanish and French. The tool also includes a research functionality providing a platform for worker and citizen science projects to collect individual data on physical thermal strain and the experienced thermal strain. The application may therefore improve the translation of heat and cold risk assessments and guidance for subpopulations. ClimApp provides the framework for personalising and downscaling weather reports, alerts and advice at the personal level, based on GPS location and adjustable input of individual factors.
Nationwide Rate of Adult ADHD Diagnosis and Pharmacotherapy from 2015 to 2018
Authors: Lee Sang-Min , Cheong Hyeon-Kyoung , Oh In-Hwan , Hong Minha
Published: October 2021

There is a paucity of published literature on the epidemiology of adult attention-deficit/hyperactivity disorder (ADHD). We investigated the time trends of the diagnostic and pharmacotherapy incidence of ADHD, including the first used medication, in the adult population based on a Korean population-based database from 2015 to 2018. The number of diagnosed cases of ADHD significantly increased from 7782 in 2015 to 17,264 in 2018 (p = 0.03), which is 0.02% to 0.04% of the total population. Similarly, the number of pharmacotherapy cases of ADHD significantly increased from 3886 in 2015 to 12,502 in 2018 (p = 0.01), which is 0.01% to 0.03% of total population. The most commonly used medication at the initiation of pharmacotherapy shifted from Penid in 2015 to Concerta in 2018. Furthermore, combination therapy with two or more drugs was the preferred method in 2016–2018. In conclusion, the identified diagnoses and pharmacotherapy incidences were very low, highlighting the need to improve the public’s awareness of adult ADHD.
Generic Drug Usage in Dentistry across Japan: Analysis Using a Japanese National Database
Authors: Ono Sachie , Komatsuzaki Akira , Iguchi Asami , Kikuchi Hitomi , Motoi Shiho , Susuga Mio
Published: October 2021

The aim of this study was to identify regional disparities in generic drug usage and to examine related factors. The database used for the analysis was the 2018 national health insurance claims data published on the Japanese Ministry of Health, Labour, and Welfare. The drugs that were targeted were a combination of brand-name and generic tetracycline ointments for periodontal treatment and lidocaine injection solution used for dental anesthesia. The usage of generic drugs was calculated and compared by prefecture based on the number of health insurance claims. The comparison of related factors was conducted using data from other national statistical survey. The results showed that the mean generic drug usage of tetracycline for periodontal treatment in all prefectures was 71.2 ± 8.1%, ranging from 45.8% to 85.3%. The mean generic lidocaine used for dental anesthesia was 47.6 ± 10.0%, ranging from 30.5% to 66.2%. The rank correlation coefficient between the two was 0.359 (p < 0.05), and the tendency of using both generic drugs was low in major metropolitan areas. Generic drug usage in Japan is low; thus, in order to reduce healthcare costs, generic drugs need to be actively used in dentistry.
Representations of Research among Newly Graduated Paramedical Professionals: A Qualitative Study
Authors: Decullier Evelyne , Chauliaguet Mathilde , Siméone Arnaud , Haesebaert Julie , Witko Agnès
Published: October 2021

Despite a keen interest in clinical research, most paramedical professionals are unwilling to play an active role. Our objective was to explore paramedical professionals’ representations of research. Using an existing database of final year paramedical students (speech therapy, occupational therapy, psychomotricity, audiometry, physiotherapy, orthoptics), we deployed a qualitative approach composed of two successive steps: (1) a free word association task, and (2) semi-structured individual interviews. Out of the 54 students who agreed to be contacted, we received 21 responses to the free word association questionnaire, and 11 interviews were conducted. The hierarchical evocation matrix revealed that the scientific representation of research is based on words defining the research and the purpose of the research. “Collaboration” was identified as being an essential part of the research process. The central core of the representation is coherent with all its components perceived as positive. The content analysis of the interviews showed a polarization around two key points: (1) participants are interested in accessing and using evidence in their practice (2) but feel less confident about and/or motivated to generate evidence themselves. This study highlights the need to develop more research-friendly environments, especially in training institutions.
Fear of Infection and the Common Good: COVID-19 and the First Italian Lockdown
Authors: Balbuena Lloyd , Monaro Merylin
Published: October 2021

In the first quarter of 2020, Italy became one of the earliest hotspots of COVID-19 infection, and the government imposed a lockdown. During the lockdown, an online survey of 2053 adults was conducted that asked about health behaviors and about the psychological and overall impact of COVID-19. The present study is a secondary analysis of that data. We hypothesized that self-control, higher socio-economic status, existing health conditions, and fear of infection were all inversely related to actions (or intentions) that violated the lockdown (i.e., infractions). Using partial least squares structural equation modeling (PLS-SEM), we found that only the fear of infection significantly dissuaded people from violating lockdown rules. Since it is not practical or ethical to sow a fear of infection, our study indicates that enacting rules and enforcing them firmly and fairly are important tools for containing the infection. This may become more important as vaccines become more widely available and people lose their fear of infection.
Adverse Childhood Experiences Distinguish Violent Juvenile Sexual Offenders’ Victim Typologies
Authors: Baglivio Michael T. , Wolff Kevin T.
Published: October 2021

Juvenile perpetrators account for over 25% of all sexual offenses, and over one-third of such offenses are against victims under the age of 18. Given empirical connections between adverse childhood experience (ACE) exposure and perpetration of violence, we create victim typologies based on the juveniles’ relationship to their victims among 5539 justice-involved adolescents who have committed violent against-person sexual felonies. Multinomial logistic regression is used to assess which covariates, including individual ACE exposures and cumulative traumatic exposures, are associated with victim typologies. This approach allows for better targeting of violence prevention efforts, as a more nuanced understanding of the increased likelihood to victimize specific victim groups lends to potential differences in treatment provision, beyond simplistic findings regarding ACE exposure increasing offending. Results indicate five classes of victim types, ranging from a low of 6.4%, with primarily strangers as victims, to 31.3%, with predominately acquaintances as victims, and only 12.9% with a diverse array of relationships to victims. Importantly, many demographic and individual risk factors, and specific traumatic exposures were related to victimizing one’s sibling, while cumulative trauma as measured by an ACE score decreased the likelihood of victimizing classmates, while increasing the likelihood of victimizing siblings and other relatives compared to victimizing acquaintances.
Systematic Review of Clinical Applications of CAD/CAM Technology for Craniofacial Implants Placement and Manufacturing of Orbital Prostheses
Authors: Tanveer Waqas , Ridwan-Pramana Angela , Molinero-Mourelle Pedro , Forouzanfar Tymour
Published: October 2021

This systematic review was aimed at gathering technical and clinical applications of CAD/CAM technology for the preoperative planning of craniofacial implants placement, designing of molds and substructures and fabrication of orbital prostheses. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, an electronic search was executed. Human studies that utilized digital planning systems for the prosthetic rehabilitation of orbital defects were included. A total of 16 studies of 30 clinical cases, which were virtually planned through various digital planning and designing software, were included. The most common preoperative data required for digital planning were CT scans in 15 cases, the 3DSS-STD-II scanning system in 5 cases, an Artec Color 3D scanner in 3 cases and a NextEngine Desktop 3D laser scanner in 2 cases. Meanwhile, the digital designing software were Ease Orbital Implant Planning EOIPlan software in eight cases, Geomagic software in eight cases, Simplant software in four cases and Artec Studio 12 Professional in three cases. Surgical templates were fabricated for 12 cases to place 41 craniofacial implants in the orbital defect area. An image-guided surgical navigation system was utilized for the placement of five orbital implants in two cases. Digital designing and printing systems were reported for the preoperative planning of craniofacial implants placement, designing of molds and substructures and fabrication of orbital prostheses. The studies concluded that the digital planning, designing and fabrication of orbital prostheses reduce the clinical and laboratory times, reduces patient visits and provide a satisfactory outcome; however, technical skills and equipment costs are posing limitations on the use of these digital systems.
New Avenues for Prevention of Work-Related Diseases Linked to Psychosocial Risks
Authors: Guillemin Michel P.
Published: October 2021

The epidemic of psychosocial risks continues to increase and the COVID-19 pandemic has even worsened this threat on workers’ health. This inexorable and evidence-based rise seems to be impervious to the preventive strategies proposed for more than 40 years. Hypotheses are proposed to explain this serious problem that drastically impacts public health and the economy. The objectives of this paper are to present, in this broad context of societal and cultural changes, how the present shift in management paradigms may represent opportunities to reduce work-related diseases. In the first part of this paper, we will summarize the situation on three main issues and their relation with psychosocial risks: (1) evolution of the occupational safety and health field, (2) change in the nature of work, and (3) emerging models of governance. In the second part, we will describe, through a few examples (among many others), how emerging models of corporate governance may reduce and prevent stress and burnout. Work is changing fundamentally, and this impacts workers’ (and managers’) health and well-being; that is why approaches in line with these changes are necessary. The COVID-19 pandemic has produced major changes in work organization. This may offer promising opportunities to reanalyze working conditions for a better control of occupational diseases and stress with all the benefits these improvements will bring for society and for individuals.
Principles of Rapid Weight Loss in Female Sambo Athletes
Authors: Todorović Nikola , Ranisavljev Marijana , Tapavički Borislav , Zubnar Andrea , Kuzmanović Jovan , Štajer Valdemar , Sekulić Damir , Veršić Šime , Tabakov Sergey , Drid Patrik
Published: October 2021

In combat sports, competitors are separated into weight divisions, to create equality between the athletes. Consequently, rapid weight loss (RWL) is a common practice in combat sports. Although the methods used to induce RWL are similar among athletes, currently, there are limited data concerning the RWL methodologies used by sambo athletes. Therefore, this study aimed at determining RWL procedures among female sambo athletes. Participants in the study were top-level athletes competing at the World Sambo Championship held in Novi Sad. A total sample of 47 female sambo athletes, of whom 24 were seniors (27.3 ± 4 year/age, 1.61 ± 0.09 m/height, 61.8 ± 8.87 kg/weight) and 23 juniors (18.7 ± 0.8 year/age, 1.66 ± 0.07 m/height, 63.7 ± 12.1 kg/weight), were examined in the study. To determine RWL methods, data were collected through a standardized questionnaire. As a result, 88.7% of the female sambo athletes declared that they intentionally cut their weight before the competition. The most commonly used methods were gradual dieting, followed by sauna, fluid restriction, and skipping meals. The most considerable influence on the RWL strategies of athletes came from coaches and personal trainers, while physicians and dietitians were far less influential. The results obtained from this representative sample highlight the most common practices concerning weight cutting prior to competition among females. Therefore, there is a need to inform and educate both athletes and coaches about the potentially harmful effects of RWL in combat sports.
Increasing Heart Rate Variability through Progressive Muscle Relaxation and Breathing: A 77-Day Pilot Study with Daily Ambulatory Assessment
Authors: Groß Daniel , Kohlmann Carl-Walter
Published: October 2021

The aim of this study was to examine whether it is possible to gradually increase heart rate variability (HRV) in healthy individuals (21 participants, M = 21.24 years, SD = 1.57, range 19 to 26) through regular exercises of average resonance frequency training (RFT; 6 breaths/min; 5 min each day) and progressive muscle relaxation (PMR; three times a week for 20 min). The effects were tested against an active control group using a linear mixed effect model with random slopes (day), random intercepts (participants) and an autoregressive error term. The special feature of this pilot study is that HRV was measured every day in an ambulatory assessment over 77 days, so that graduate long-term effects on HRV can be mapped. The results indicated that the PMR group significantly increased their HRV compared to the active control group. However, no effect was observed for the RFT group. Possible explanations for these results and important recommendations for subsequent studies are provided.
Differential Effects of Human P301L Tau Expression in Young versus Aged Mice
Authors: Hunsberger Holly C. , Setti Sharay E. , Rudy Carolyn C. , Weitzner Daniel S. , Pfitzer Jeremiah C. , McDonald Kelli L. , Hong Hao , Bhattacharya Subhrajit , Suppiramaniam Vishnu , Reed Miranda N.
Published: October 2021

The greatest risk factor for developing Alzheimer’s disease (AD) is increasing age. Understanding the changes that occur in aging that make an aged brain more susceptible to developing AD could result in novel therapeutic targets. In order to better understand these changes, the current study utilized mice harboring a regulatable mutant P301L human tau transgene (rTg(TauP301L)4510), in which P301L tau expression can be turned off or on by the addition or removal of doxycycline in the drinking water. This regulatable expression allowed for assessment of aging independent of prolonged mutant tau expression. Our results suggest that P301L expression in aged mice enhances memory deficits in the Morris water maze task. These behavioral changes may be due to enhanced late-stage tau pathology, as evidenced by immunoblotting and exacerbated hippocampal dysregulation of glutamate release and uptake measured by the microelectrode array technique. We additionally observed changes in proteins important for the regulation of glutamate and tau phosphorylation that may mediate these age-related changes. Thus, age and P301L tau interact to exacerbate tau-induced detrimental alterations in aged animals.
C-Reactive Protein Controls IL-23 Production by Human Monocytes
Authors: Geyer Chiara E. , Newling Melissa , Sritharan Lathees , Griffith Guillermo R. , Chen Hung-Jen , Baeten Dominique L. P. , den Dunnen Jeroen
Published: October 2021

C-reactive protein (CRP) is an acute-phase protein in humans that is produced in high quantities by the liver upon infection and under inflammatory conditions. Although CRP is commonly used as a marker of inflammation, CRP can also directly contribute to inflammation by eliciting pro-inflammatory cytokine production by immune cells. Since CRP is highly elevated in serum under inflammatory conditions, we have studied the CRP-induced cytokine profile of human monocytes, one of the main innate immune cell populations in blood. We identified that CRP is relatively unique in its capacity to induce production of the pro-inflammatory cytokine IL-23, which was in stark contrast to a wide panel of pattern recognition receptor (PRR) ligands. We show that CRP-induced IL-23 production was mediated at the level of gene transcription, since CRP particularly promoted gene transcription of IL23A (encoding IL-23p19) instead of IL12A (encoding IL-12p35), while PRR ligands induce the opposite response. Interestingly, when CRP stimulation was combined with PRR ligand stimulation, as for example, occurs in the context of sepsis, IL-23 production by monocytes was strongly reduced. Combined, these data identify CRP as a unique individual ligand to induce IL-23 production by monocytes, which may contribute to shaping systemic immune responses under inflammatory conditions.
Oleil Hydroxytyrosol (HTOL) Exerts Anti-Myeloma Activity by Antagonizing Key Survival Pathways in Malignant Plasma Cells
Authors: Todoerti Katia , Gallo Cantafio Maria Eugenia , Oliverio Manuela , Juli Giada , Rocca Carmine , Citraro Rita , Tassone Pierfrancesco , Procopio Antonio , De Sarro Giovambattista , Neri Antonino , Viglietto Giuseppe , Amodio Nicola
Published: October 2021

Polyphenols from olive oil are endowed with several biological activities. Chemical modifications have been recently applied to these compounds to improve their therapeutic activity in different pathological settings, including cancer. Herein, we describe the in vitro effects on multiple myeloma (MM) cells of oleil hydroxytyrosol (HTOL), a synthetic fatty ester of natural hydroxytyrosol with oleic acid. HTOL reduced the viability of various human MM cell lines (HMCLs), even when co-cultured with bone marrow stromal cells, triggering ER stress, UPR and apoptosis, while it was not cytotoxic against healthy peripheral blood mononuclear cells or B lymphocytes. Whole-transcriptome profiling of HTOL-treated MM cells, coupled with protein expression analyses, indicate that HTOL antagonizes key survival pathways for malignant plasma cells, including the undruggable IRF4–c-MYC oncogenic axis. Accordingly, c-MYC gain- and loss-of-function strategies demonstrate that HTOL anti-tumor activity was, at least in part, due to c-MYC targeting. Taken together, these findings underscore the anti-MM potential of HTOL, providing the molecular framework for further investigation of HTOL-based treatments as novel anti-cancer agents.
Growth of Biological Complexity from Prokaryotes to Hominids Reflected in the Human Genome
Authors: Vinogradov Alexander E. , Anatskaya Olga V.
Published: October 2021

The growth of complexity in evolution is a most intriguing phenomenon. Using gene phylostratigraphy, we showed this growth (as reflected in regulatory mechanisms) in the human genome, tracing the path from prokaryotes to hominids. Generally, the different regulatory gene families expanded at different times, yet only up to the Euteleostomi (bony vertebrates). The only exception was the expansion of transcription factors (TF) in placentals; however, we argue that this was not related to increase in general complexity. Surprisingly, although TF originated in the Prokaryota while chromatin appeared only in the Eukaryota, the expansion of epigenetic factors predated the expansion of TF. Signaling receptors, tumor suppressors, oncogenes, and aging- and disease-associated genes (indicating vulnerabilities in terms of complex organization and strongly enrichment in regulatory genes) also expanded only up to the Euteleostomi. The complexity-related gene properties (protein size, number of alternative splicing mRNA, length of untranslated mRNA, number of biological processes per gene, number of disordered regions in a protein, and density of TF–TF interactions) rose in multicellular organisms and declined after the Euteleostomi, and possibly earlier. At the same time, the speed of protein sequence evolution sharply increased in the genes that originated after the Euteleostomi. Thus, several lines of evidence indicate that molecular mechanisms of complexity growth were changing with time, and in the phyletic lineage leading to humans, the most salient shift occurred after the basic vertebrate body plan was fixed with bony skeleton. The obtained results can be useful for evolutionary medicine.
Constitutive Oxidative Stress by SEPHS1 Deficiency Induces Endothelial Cell Dysfunction
Authors: Jung Jisu , Kim Yoomin , Na Jiwoon , Qiao Lu , Bang Jeyoung , Kwon Dongin , Yoo Tack-Jin , Kang Donghyun , Kim Lark Kyun , Carlson Bradley A. , Hatfield Dolph L. , Kim Jin-Hong , Lee Byeong Jae
Published: October 2021

The primary function of selenophosphate synthetase (SEPHS) is to catalyze the synthesis of selenophosphate that serves as a selenium donor during selenocysteine synthesis. In eukaryotes, there are two isoforms of SEPHS (SEPHS1 and SEPHS2). Between these two isoforms, only SEPHS2 is known to contain selenophosphate synthesis activity. To examine the function of SEPHS1 in endothelial cells, we introduced targeted null mutations to the gene for SEPHS1, Sephs1, in cultured mouse 2H11 endothelial cells. SEPHS1 deficiency in 2H11 cells resulted in the accumulation of superoxide and lipid peroxide, and reduction in nitric oxide. Superoxide accumulation in Sephs1-knockout 2H11 cells is due to the induction of xanthine oxidase and NADPH oxidase activity, and due to the decrease in superoxide dismutase 1 (SOD1) and 3 (SOD3). Superoxide accumulation in 2H11 cells also led to the inhibition of cell proliferation and angiogenic tube formation. Sephs1-knockout cells were arrested at G2/M phase and showed increased gamma H2AX foci. Angiogenic dysfunction in Sephs1-knockout cells is mediated by a reduction in nitric oxide and an increase in ROS. This study shows for the first time that superoxide was accumulated by SEPHS1 deficiency, leading to cell dysfunction through DNA damage and inhibition of cell proliferation.
Identification of Signaling Pathways for Early Embryonic Lethality and Developmental Retardation in Sephs1−/− Mice
Authors: Bang Jeyoung , Han Minguk , Yoo Tack-Jin , Qiao Lu , Jung Jisu , Na Jiwoon , Carlson Bradley A. , Gladyshev Vadim N. , Hatfield Dolph L. , Kim Jin-Hong , Kim Lark Kyun , Lee Byeong Jae
Published: October 2021

Selenophosphate synthetase 1 (SEPHS1) plays an essential role in cell growth and survival. However, the underlying molecular mechanisms remain unclear. In the present study, the pathways regulated by SEPHS1 during gastrulation were determined by bioinformatical analyses and experimental verification using systemic knockout mice targeting Sephs1. We found that the coagulation system and retinoic acid signaling were most highly affected by SEPHS1 deficiency throughout gastrulation. Gene expression patterns of altered embryo morphogenesis and inhibition of Wnt signaling were predicted with high probability at E6.5. These predictions were verified by structural abnormalities in the dermal layer of Sephs1−/− embryos. At E7.5, organogenesis and activation of prolactin signaling were predicted to be affected by Sephs1 knockout. Delay of head fold formation was observed in the Sephs1−/− embryos. At E8.5, gene expression associated with organ development and insulin-like growth hormone signaling that regulates organ growth during development was altered. Consistent with these observations, various morphological abnormalities of organs and axial rotation failure were observed. We also found that the gene sets related to redox homeostasis and apoptosis were gradually enriched in a time-dependent manner until E8.5. However, DNA damage and apoptosis markers were detected only when the Sephs1−/− embryos aged to E9.5. Our results suggest that SEPHS1 deficiency causes a gradual increase of oxidative stress which changes signaling pathways during gastrulation, and afterwards leads to apoptosis.