bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementasi Performance Assessment Berbasis VE.Rubric Pada Kompetensi Making Bed di SMK Akomodasi Perhotelan
Authors: Winona Khoerunnisa  , Yoyoh Jubaedah  , Neni Rohaeni
Published: December 2022

Penelitian ini bertujuan untuk mengetahui capaian hasil peserta didik dalam praktik making bed dan mengetahui respon guru mata pelajaran making bed sebagai pengguna aplikasi VE.Rubric. Penelitian ini menggunakan metode deksriptif untuk mengimplementasikan alat penilaian berbasis VE.Rubric pada praktik making bed. Data yang diperoleh didukung oleh hasil dari observasi langsung dalam penilaian praktik di SMK Akomodasi Perhotelan dan dari angket yang diberikan kepada guru mata pelajaran making bed dalam menggunakan aplikasi VE.Rubric. Hasil capaian peserta didik selanjutnya diuji reliabilitasnya menggunakan aplikasi SPSS dengan metode Cronbach Alpha. Berdasarkan dari hasil implementasi ditemukan bahwa seluruh peserta didik kompeten dalam melaksanakan praktik making bed menggunakan alat penilaian yang dikembangkan oleh peneliti sebelumnya dan aplikasi VE.Rubric memberikan kemudahan pada guru dalam manajemen penilaian peserta didik. Hasil uji reliabilitas capaian peserta didik dinilai reliabel karena berada di atas batas minimal realibilitas dengan nilai 0,747.
ANALISIS PREFERENSI KONSUMEN TERHADAP KEPUTUSAN PEMBELIAN ES KOPI SUSU (STUDI KASUS PADA KONSUMEN OMBE KOFIE SUMMARECON MAL BEKASI)
Authors: Donovan Jessen , Hurdawaty Ramon
Published: December 2022

Coffee served in a coffee shop does not only sell the taste and type of coffee because in a coffee shop there are other attributes. Attributes of coffee shops such as location, facilities, and infrastructure, the atmosphere of the coffee shop are also thought to influence coffee consumers' preferences for visiting and consuming coffee. Consumer preferences will influence the purchasing decisions of coffee consumers. Knowing consumer preferences is one of the strengths of each coffee shop to be able to face competition in the long term. The purpose of this study is to determine consumer preferences in buying iced milk coffee and also want to find out from the preferences that exist, which preference factors are most considered by consumers in deciding to buy the product. This research is a quantitative study using descriptive methods and survey techniques. For the sampling method used in this study is the purposive sampling method. The data collection method used a questionnaire distributed to 91 respondents, which will be analyzed using the chi-square test and also multi-attribute fishbein. Attributes of consumer preferences in this study which refer to several previous studies have been determined by the author, the attributes of taste, price, brand, and packaging. Chi-square test results if X2 count > X2 table, then the null hypothesis (Ho) is rejected and the alternative hypothesis (Ha) is accepted, that with the results of X2 count all items of consumer preference attributes are greater than X2 tables, then Ho is rejected and Ha is accepted. By multiplying the confidence number (bi) and also the evaluation (ei), the consumer attitude index (Ao) is obtained, where the results can be sorted from the most considered are taste, price, packaging, and brand.
Analisis Persepsi Mahasiswa Yogyakarta dan Jawa Tengah tentang Konsep Green Hotel berdasarkan Pengalaman Kunjungan
Authors: Pusfitasari Dewi Vitama , Mukoningah Fuadatul , Rahmawati Rahmawati , Marifah Iis Elia , Javid Elan Mustafa , Zamhari Muhammad
Published: December 2022

Green hotel muncul sebagai salah satu solusi atas permasalahan lingkungan yang terjadi. Akan tetapi, apresiasi positif terhadap pelaksanan green hotel masih diperlukan. Penelitian ini mengkaji apakah green hotel sebagai salah satu solusi permasalahan lingkungan mendapatkan apresiasi positif dan diminati oleh pengunjung hotel. Penelitian dilakukan dengan metode deskriptif kualitatif dengan mengajukan kuesioner pada mahasiswa Yogyakarta dan Jawa Tengah terkait pengalamannya menginap di Hotel Yogyakarta. Berdasarkan hasil penelitian didapat bahwa 34,28% sangat setuju lebih memilih tinggal di green hotel yang peduli dengan persoalan lingkungan, 57,14% setuju, 5,71% tidak setuju, 2,86% sangat tidak setuju. Selain itu, minat untuk dapat tinggal di green hotel sangat tinggi dengan persentase 28,57% sangat berminat, 65,71% berminat, 5,72% tidak berminat, 0% sangat tidak berminat. Sehingga green hotel sebagai solusi atas permasalahan lingkungan mendapat apresiasi positif dan minat yang tinggi dari calon pengunjung dan pengunjung hotel dan memiliki potensi besar untuk berkembang lebih baik.
An Analysis of Winesburg, Ohio from the Perspective of Fromm’s Alienation Theory
Authors: Yongju Yuan
Published: December 2022

Winesburg, Ohio is Sherwood Anderson’s representative collection of short stories, and it occupies an important position in the history of American literature. Since the publication of this collection, many foreign critics have analyzed and interpreted it from various perspectives. Guided by Fromm’s alienation theory, this paper discusses the alienation phenomenon in Winesburg, Ohio from three aspects: self-alienation, alienation of interpersonal relationships, and alienation of the relationship between people and society.
The Role of Teachers in Optimizing Scientific-Based Learning in Elementary Schools
Authors: Khasana Nur , Nurdiansyah Nurdiansyah
Published: December 2022

This study aims to find out what the teacher's role is in optimizing scientific-based learning at SDN Rangkah Kidul Sidoarjo. This study uses qualitative research using a phenomological approach. This approach uses field research. The findings of the data at SDN Rangkah Kidul in the role of teachers in optimizing scientific-based learning are that all teachers have taught scientific-based learning, namely teachers use several tools in scientific learning such as using the methods they teach and making designs before learning takes place and making evaluation of scientific-based learning. Besides that, teachers also face obstacles in using scientific learning due to the difficulty of teachers finding other methods in understanding their students and the lack of learning media where teachers have difficulty finding ideas in the learning process.
Moral Education Values ​​in Sang Kiai Film (Teun Van Dijk Discourse Analysis)
Authors: Nur Firda Ardianti , Romadlon Dzulfikar Akbar
Published: December 2022

This study aims to find out what the values ​​of moral education are contained in the Sang Kiai film and how the social cognition is behind the scenario writer in making the Sang Kiai film script. The type of research used is descriptive qualitative research with data analysis techniques using discourse analysis of Teun Van Dijk. Based on the results of research that has been analyzed using three elements, namely the macro structure, super structure and micro structure, it is found that several values ​​of moral education are shown or shown in the Sang Kiai film including: sincere behavior, humbleness or humility, responsibility, compassion, fear of Allah SWT. , be devoted both to parents, and stay away from prejudice to others, regarding the social cognition contained in the film Sang Kiai is about the struggle of KH Hasyim Asyari who did not want to compromise with the invaders and the obstacles that KH Hasyim Asyari had to go through. Which in this film is framed with the values ​​of moral education. The value of moral education shown in the film Sang Kiai can be implemented in everyday life both in the family, community, school and other places, so that it is expected to become a good habit.
Identification of Genes in Positive Alleles Marking Type 2 Diabetes Mellitus Using Primer A18
Authors: Firda Aminatul , Mushlih Miftahul
Published: December 2022

Diabetes mellitus type 2 (DMT2) is a disorder characterized by hyperglycemia due to impaired insulin secretion and insulin resistance. The purpose of this study was to identify the gene involved in the positive allele of DMT2 marker using A18 primer and is a type of exploratory descriptive study. The samples used were 2 samples of DMT2 patients from the villages of Taman and Balongbend, and 8 samples of DNA collection at the Molecular Biology Laboratory, Muhammadiyah University of Sidoarj. Based on the genetic analysis carried out, the GATB gene (Glutamyl-tRNA Amidotransferase Sub Unit B) was identified in the positive allele with a homology value of "percentage identity" between the sample sequence and the sequence data in the NCBI Genbank of 80 and 88%. This research hypothesizes that the GATB gene has a relationship with the emergence of DMT2 as evidenced by the relationship between the gene and the performance of mitochondria to produce ATP which is needed by pancreatic beta cells to produce insulin.
Differences in DNA Purity Test Using UV-Vis Spectrophotometer and Nanodrop Spectrophotometer in Type 2 Diabetes Mellitus Patients
Authors: Dewanata Pandu Aji , Mushlih Miftahul
Published: December 2022

DNA quality test is one of the basic techniques in Molecular Biology which aims to determine the presence or absence of protein and RNA contamination. DNA quantity test can be done using a spectrophotometer. Spectrophotometer is a tool used to measure the concentration of a compound based on its ability to absorb light. The purpose of this study was to determine differences in DNA purity as measured by UV-Vis Spectrophotometer and Nanodrop Spectrophotometer. The method used in this research is descriptive exploratory with purposive sampling technique. The number of samples used is 15 samples. The results of this study are that there are differences in the concentration and purity of DNA from quantitative tests with UV-Vis spectrophotometers and Nanodrops obtained based on statistical tests using the T Dependent Test. The result of this research is that in measuring DNA purity there is a difference in DNA purity because the results of Sig (2-Tailed) use 0.001 or below 0.05 (Ha is accepted). And based on statistical tests on DNA concentration measurements, it is known that there are differences in DNA concentrations.
The Effect of Tax Planning, Deferred Tax Expense, Leverage, and Financial Distress on Earnings Management in Manufacturing Companies in the Consumer Goods Industry Sector Listed on the IDX in 2014-2018
Authors: Andayani Fatma Dwi , Setiyono Wisnu Panggah
Published: December 2022

This study aims to examine the effect of tax planning, deferred tax burden, leverage, and financial distress on earnings management. The approach used in this study is a quantitative approach with a sampling technique using purposive sampling method. The sample in the study was 10 manufacturing companies in the consumer goods industry sector listed on the IDX in 2014-2018. The analytical technique used in this study is panel data regression analysis with the help of the Eviews9 program. The results of this study indicate that the tax planning variable has no effect on earnings management, deferred tax expense has a negative effect on earnings management, leverage has a positive effect on earnings management, financial distress has no effect on earnings management and simultaneously tax planning, deferred tax expense, leverage, financial distress has no effect on management.
The Effect of Liquidity and Profitability on Stock Prices With Dividend Policy as Moderation in Manufacturing Companies Listed on the Stock Exchange in 2016-2018
Authors: Mardianti Any , Dewi Santi Rahma
Published: December 2022

This study aims to determine the effect of liquidity, and profitability on stock prices with dividend policy as a moderating variable on the Indonesia Stock Exchange in 2016 – 2018. The method used is purposive sampling and produces 38 sample companies, so the total research data is 114 data. Hypothesis testing is done by using multiple linear regression analysis and regression analysis. The results show that liquidity has a significant positive effect on stock prices, profitability has a significant positive effect on stock prices, dividend policy has a significant positive effect on stock prices. Dividend policy weakens the relationship between liquidity and firm value. Dividend policy strengthens the relationship between profitability and firm value. The results of the coefficient of determination test show that the independent variable, moderating variable and the interaction of the two variables are only able to explain the dependent variable by 22.9%, while the remaining 78.1% is explained by other variables not explained in this study.
Effect of Capital Adequacy Ratio, Non Performing Loan and Loan to Deposit Ratio on Return On Assets in Banks listed on the Indonesia Stock Exchange for the 2015-2019 Period
Authors: Fakhiroh Silvi Zakiyatul , Hariasih Misti
Published: December 2022

The technique of taking is using purposive sampling method. The sample in this study were 20 companies listed on the Indonesia Stock Exchange in 2015-2019.The data used in this study is secondary data taken from the Indonesia Stock Exchange. Data analysis uses Eviews 9 analysis with the aim of testing the capital adequacy ratio (X1), non performing loans (X2), loan to deposit ratio (X3), to return on assets (Y). The results of this study indicate that simultaneously there is a significant influence between the capital adequacy ratio, non-performing loans and loan to deposit ratios on return on assets. Meanwhile, partially non performing loans have a negative and significant effect on return on assets. The capital adequacy ratio has a negative and insignificant effect on return on assets.
Analysis of Sales and Cash Receipt Accounting Information Systems To Improve Internal Control Over Revenue At PT. Indomarco Prismatama Sidoarjo Branch Office
Authors: Astutik Yuli , Nurasik Nurasik
Published: December 2022

The accounting system for sales and cash receipts operated at PT Indomarco Prismatama is used to improve internal control over revenue at PT Indomarco Prismatama in Sidoarjo branch offices. This accounting system is carried out to minimize errors and fraud in the process of selling and receiving cash, because there are executors in the field who deliberately cheat in carrying out their duties, but there are also executors who make mistakes but they do not intentionally or have no intention. The error is due to a procedure that was not executed. Therefore, the existence of an accounting system will be able to support the performance of employees in carrying out their duties properly.
The Influence of Intellectual Intelligence, Emotional Intelligence, and Spiritual Intelligence on Employee Performance with Intervening Variable Job Satisfaction CV. Kirana Bahari.
Authors: Yuda Faiz Wachida , Sumartik Sumartik
Published: December 2022

This study aims to determine Intellectual Intelligence, Emotional Intelligence, and Spiritual Intelligence on Employee Work Performance with Job Satisfaction Intervening Variable CV. Kirana Bahari. This research is a type of quantitative research with hypothesis testing. The sample used in this study were 50 employees of CV. Kirana Bahari. The analytical tool used in this research is partial least square (PLS). The term PLS specifically means the calculation of the optimal least square fit of the correlation or variance matrix. The primary data in this study were obtained from a questionnaire whose measurement was using a Likert scale which was tested for validity and reliability. The results of this study prove that intellectual intelligence affects job satisfaction, emotional intelligence affects job satisfaction, spiritual intelligence affects job satisfaction, intellectual intelligence affects work performance, emotional intelligence affects work performance, spiritual intelligence affects job performance, job satisfaction affects job performance. work performance, intellectual intelligence affects job performance mediated by job satisfaction, emotional intelligence affects job performance mediated by job satisfaction, emotional intelligence affects job performance mediated by job satisfaction.
The Influence of Voluntary Disclosure, Independent Commissioners and Information Asymmetry on Cost of Debt in Metal Sub-Sector Manufacturing Companies Listing on the IDX for the 2013-2018 Period
Authors: Khoiri Amalia , Sriyono Sriyono
Published: December 2022

This study aims to examine the effect of voluntary disclosure, independent commissioners and information asymmetry on the cost of debt. The approach used in this study is a quantitative approach. The population used in this study is the company. The sampling technique used purposive sampling method. The sample in the study was 12 companies listed on the IDX for the period 2013-2018. The data used in this study is secondary data taken from the Indonesia Stock Exchange. Data analysis uses Eviews 10 analysis with the aim of testing voluntary disclosure, independent commissioners, and information asymmetry on the cost of debt. The results of this study indicate that voluntary disclosure has a significant effect on the cost of debt, independent commissioners have no significant effect on the cost of debt, information asymmetry has a significant effect on the cost of debt, and voluntary disclosure, independent commissioners and information asymmetry have a joint effect on the cost of debt.
Ways to Develop the Creative Qualities of Technological Education Teacher
Authors: Chorshanbiyevich Dusyarov Xudoymurod
Published: December 2022

This article analyzes ways to develop the creative qualities of technological education teacher and emphazises the development of world civilization. Therefore, there are the concepts of "innovation" and "innovation", and it is necessary to point out the main differences between them. At the same time, new directions of activity will be opened in this article.
Cognitive Approach to Synonymic Relationship in Terminology
Authors: Khujakulov Sunnatullo Anvar ugli
Published: December 2022

The complex and least studied aspects of the study of terms include questions of their systemic organization at the level of lexico-semantic paradigmatics. An important problem that requires a detailed study on the material of various term systems is the implementation of the semantic process of synonymy in terminology. Based on this, the article reveals the content of the term "terminological synonymy". The main attention of the author is drawn to the generalization of theoretical views on the essence of the phenomenon of synonymy in terminology. The study analyzes the cognitive approach to synonymic relationship in terminology, including the interpretation of the concepts of "synonym", "doublet" and "variant", also offers its own understanding of these concepts.
Bukhara-India Relations during the Ashtarkhanid Dynasty
Authors: Jalolidinug’li Davronov Mukhammad
Published: December 2022

This article deals with the foreign diplomatic relations of the Ashtarkhanid dynasty with India, which ruled the Bukhara Khanate in the middle of the XVII-XVIII centuries. When the Ashtarkhanid dynasty came to power, it maintained active diplomatic relations with its closest neighbors in the region, the Khiva Khanate, Iran, the later Kokand Khanate, and other countries. In this regard, in the diplomatic relations with the Baburid dynasty we are talking about, the relations between the Baburid rulers Jahangir, Shah Jahan and subsequent rulers of Imamqulikhan, Nadir Muhammad and other Ashtarkhani rulers were discussed.
Speaking From Reading Science by Working on Text
Authors: Bakhtiyorovna Sattarova Marjona , Ravshanovna Sheranova Guzal
Published: December 2022

The article analyzes the methodological rules and principles of speech development in primary school reading lessons.
The Political Map of the World and its Specific Features
Authors: Eshmamatovich Boymatov Bahrom
Published: December 2022

The article discusses the world political map and its specific aspects, including quantitative changes in the world political map, qualitative changes, political and geographical changes on the map, evolutionary, revolutionary, military -Political conditional changes are briefly studied.
The Issue of Artistic Image of Nature and Method In The Works Of Isajan Sultan (On The Example Of “The Missing Motherland”)
Authors: Davronova Shohsanam G'aybulloevna
Published: December 2022

The article describes the views of the writer Isajon Sultan on the art of creating an artistic image, his methodological research on the example of the story "Ona yurt sog’inchi".
Use of Digital Cadastral Map in Land Information Systems.
Authors: Asadova Manzura Akhatovna  , Khamraev Salahitdin Ataevich  , K.M.Mukhamadov
Published: December 2022

This paper presents the problem of cadastral maps. The cadastre that existed until now, consisting of paper maps and land books, is now becoming insufficient. Its shortcomings cause developments leading to its improvement. One way is to create a Land Information System.
Using of Case Technology in Educational Systems as an Interactive Method
Authors: Laylo Gulomjonovna Sattorova,
Published: December 2022

The case study method (analysis of specific situations) is one of the options for applying modern pedagogical technologies in the practice of education aimed at solving the problems of the SES. Analysis of specific learning situations (case study) is a teaching method designed to improve skills and gain experience in the following areas: identifying, selecting and solving problems; work with information - understanding the meaning of the details described in the situation; analysis and synthesis of information and arguments; work with assumptions and conclusions; evaluation of alternatives; making decisions; listening and understanding other people are group work skills.
Stepwise Lithospheric Delamination Leads to Pulsed Cenozoic Uplifts of Central Tien Shan
Authors: Zhao Haixiang , Huang Zhouchuan , Yuan Xiaohui
Published: December 2022

The Tien Shan provides an ideal site to study mechanism of intracontinental orogeny due to distant effect of Indo-Asian collision. We investigate lithospheric structures, in particular the lithosphere-asthenosphere boundary (LAB), of Central Tien Shan (CTS) using S wave receiver functions. The results show distinct structures across the orogen. Under the southern CTS, the LAB is shallower than that of the Tarim Basin; a 50 km vertical offset implies that part of the lithosphere has been delaminated. Under the middle CTS, two phases of negative velocity gradient are obtained, which may indicate a new LAB and an ongoing delamination underneath. Under the northern CTS and Kazakh Shield northward, the lithosphere is stable although the LAB inclines southward slightly. The two periods of lithospheric delamination under the southern and middle CTS account well for pulsed uplifts of the Tien Shan at ~11-8 Ma and ~5-0 Ma, respectively.
On using undirected graph techniques for directed graphs through Category Theory
Authors: Guerra Sebastian Prado , George Vivek Kurien , Morar Vikash , Joshua Roldan , Silva Gabriel
Published: December 2022

Many complex systems are modeled as graphs. Depending on the setting, graphs can be either directed or undirected.While many computational tools have been developed for both types of graphs, some tools only exist for undirected graphs.Thus, creating a 'bridge' that connects directed graphs to undirected graphs would unlock the potential for using undirected graph techniques in appropriate directed graph contexts.We used Category Theory in a novel way to map a simple directed graph to a bipartite undirected graph that we call a prime graph.Formally, we show that there exists an isomorphism between the category of simple directed graphs and a category of prime graphs whose objects are labeled undirected bipartite graphs. The labeling is what gives the notion of direction to an undirected graph. By taking advantage of the isomorphism between these two categories, we extend undirected graph techniques to directed graph contexts by converting the directed graphs into prime graphs. We demonstrate this framework by applying it to the problems of network alignment and spectral graph clustering.
Risk factor analysis and a new prediction model of venous thromboembolism after pancreaticoduodenectomy
Authors: Yin ZhiJie , Huang YingJie , Chen QiLong
Published: December 2022

Aim
The present study aimed to identify risk factors for venous thromboembolism (VTE) after pancreaticoduodenectomy (PD) and to develop and externally validate a predictive model for the risk of venous thrombosis.
Methods
We retrospectively collected data from 352 patients who visited our hospital to undergo PD from January 2018 to March 2022. The number of patients recruited was divided in an 8:2 ratio by using the random split method, with 80% of the patients serving as the training set and 20% as the validation set. The least absolute shrinkage and selection operator (LASSO) regression model was used to optimize feature selection for the VTE risk model. Multivariate logistic regression analysis was used to construct a prediction model by incorporating the features selected in the LASSO model. C-index, receiver operating characteristic curve, calibration plot, and decision curve were used to assess the accuracy of the model, to calibrate the model, and to determine the clinical usefulness of the model. Finally, we evaluated the prediction model for external validation.
Results
The predictors included in the prediction nomogram were sex, age, gastrointestinal symptoms, hypertension, diabetes, operative method, intraoperative bleeding, blood transfusion, neutrophil count, prothrombin time (PT), activated partial thromboplastin time (APTT), aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AST/ALT), and total bilirubin (TBIL). The model showed good discrimination with a C-index of 0.827, had good consistency based on the calibration curve, and had an area under the ROC curve value of 0.822(P < 0.001, 95%confidence interval:0.761–0.882). A high C-index value of 0.894 was reached in external validation. Decision curve analysis showed that the VTE nomogram was clinically useful when intervention was decided at the VTE possibility threshold of 10%.
Conclusion
The novel model developed in this study is highly targeted and enables personalized assessment of VTE occurrence in patients who undergo PD. The predictors are easily accessible and facilitate the assessment of patients by clinical practitioners.
“Factors associated with mediastinal lymph node positivity in proximal gastric tumor patients undergoing curative surgery”
Authors: Parsak Cem Kaan , Topal Uğur , Altiok Merih , Capkinoglu Emir , Bali Cagla , Yalav Orcun , Rencuzogullari Ahmet
Published: December 2022

Purpose: This study investigated the risk factors associated with mediastinal lymph node metastases due to proximal gastric cancer.
Methods The study included patients who had surgical resection and Transcrural lymphadenectomy for proximal gastric tumors between January 2012 and January 2020. The patients were divided into Group1 (negative) and Group2 (positive) according to the positivity of mediastinal lymph nodes. These groups were compared for clinical variables. The diagnostic value of composite immunonutritional and inflammatory indices in predicting lymph node positivity was examined.
Results There were 88 patients in our study. Group1 included 54 and Group2 included 34 patients.Among the laboratory parameters, only CRP was higher in Group 2 (4.58 vs. 10.7, p= 0.044). The rate of postoperative respiratory complications (5.6% vs. 29.4%, p:0.002) was higher in Group2 The tumor size (25.3 vs. 33 mm, p:0.0001), was higher in Group2. Tumors were more advanced in Group2 (p<0.001). Among the composite indices, only the neutrophil-to-lymphocyte ratio had a diagnostic value, with a sensitivity of 67.65% and a specificity of 55.56% at a cut-off point of >2.19. According to the multivariate analysis, a tumor size of >3 cm, a CRP value of >7, and tumor localization were independent risk factors.
Conlusion Our study found that mediastinal lymph node positivity was associated with elevated CRP and that these patients had more advanced tumors and poor histopathological characteristics. Knowing the relationship between clinicopathological characteristics and mediastinal lymph node positivity in proximal gastric tumors can be useful in determining the surgical strategy for EGJ tumors.
Treatment of Glucocorticoid- induced hyperglycemia in hospitalized patients - A Systematic Review and Meta- Analysis
Authors: Struja Tristan , Nitritz Neele , Alexander Islay , Kupferschmid Kevin , Hafner Jason F. , Spagnuolo Carlos C. , Schuetz Philipp , Mueller Beat , Blum Claudine A.
Published: December 2022

Purpose:Glucocorticoid (GC)-induced hyperglycemia is a frequent issue, however there are no specific guidelines for this diabetes subtype. Although treat-to-target insulin is recommended in general to correct hyperglycemia, it remains unclear which treatment strategy has a positive effect on outcomes. We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess whether treating GC-induced hyperglycemia improves clinical outcomes.
Methods: MEDLINE and EMBASE were systematically searched for RCTs on adults reporting treatment and outcomes of GC-induced hyperglycemia since the beginning of the data bases until August 2020. Glucose-lowering strategies as compared to usual care were investigated.
Results: We found 14 RCTs with 595 patients and included seven trials in the quantitative analysis. Patients with an intensive glucose-lowering strategy had lower standardized mean glucose levels of – 0.42 mmol/l (95%CI -0.65 to -0.19) compared to usual care group patients. There was no increase in hypoglycemic events in the intensively treated groups (RR 0.87, 95%CI 0.48-1.56). Overall, we did not have enough trials reporting clinical outcomes for a quantitative analysis with only one trial reporting mortality.
Conclusion: In GC-induced hyperglycemia, tight glucose control has a moderate effect on mean glucose levels with no apparent harmful effect regarding hypoglycemia, but there is insufficient data whether an intensive glucose-lowering strategy improves clinical outcomes.
Systematic review registration
Registered as CRD42020147409 at PROSPERO (https://www.crd.york.ac.uk/prospero/) on April 28, 2020
Early initiation of breastfeeding and associated factors among mothers with children <2 years in Simiyu region, Tanzania
Authors: Shirima Laura J , Mlay Henry L , Mkuwa Serafina , Fabian Agatha , Mushy Stella E. , Ngalesoni Frida N , Mboya Innocent B , Manongi Rachel N
Published: December 2022

Background
Breast milk provides infants with complete nutrition for immune development and protection against childhood diseases. Lack of breastfeeding increases the risk of infant and child morbidity and mortality. Early initiation of breastfeeding (EIBF) aids in the provision of colostrum to newborns, which provides protection against infection and improves newborn and infant survival.
Objective
To determine the prevalence of EIBF and associated factors among mothers with children < 2 years in the Simiyu region, Tanzania.
Methodology:
The study utilized data from a cross-sectional study conducted by AMREF Health Africa among women of reproductive age (15–49 years) in Simiyu region, Tanzania. An interviewer-administered questionnaire was used for data collection. The dependent variable was early breastfeeding initiation, measured by asking women on the time they started to breastfeed their child after birth. Stata 15 was used for data cleaning and analysis. Continuous variables were summarised using mean and standard deviation, while categorical variables using frequency and percentage. A multilevel logistic regression analysis was used to determine factors associated with EIBF.
Results
The mean age of 669 women analyzed was 28.29 years (SD = 6.8). The prevalence of EIBF was 62.2%, ranging from 52.7% in Bariadi district to 73.3% in Maswa district. Lower odds of EIBF were among women who had a caesarian section (OR = 0.41; 95% CI = 0.17–0.98) and those who gave birth to male children (OR = 0.57; 95%CI = 0.39–0.82). And higher odds of EIBF were among mothers who had their babies placed on their chest/abdomen (skin-to-skin-contact) (OR = 2.40; 95%CI = 1.53–3.83) and women from Maswa district (OR = 2.73; 95%CI = 1.09–6.89).
Conclusion
The prevalence of EIBF in Simiyu is slightly lower than the national target (65% by 2025) and good according to the WHO classification. Nonetheless, it’s low in comparison to the global target (70% by 2030). The practice of skin-to-skin contact between mother and child should be encouraged immediately after delivery. Education emphasising EIBF without child sex discrimination should be provided to women at antenatal care (ANC) and in the community at large.
Effectiveness of an Artificial Intelligence Clinical Assistant Decision Support System to Improve the Incidence of Hospital-Associated Venous Thromboembolism: A Prospective, Randomised Controlled Study
Authors: Huang Xiaoyan , Zhou Shuai , Ma Xudong , Jiang Songyi , Xu Yuanyuan , You Yi , Qu Jieming , Shang Hanbing , Lu Yong
Published: December 2022

Background

Thromboprophylaxis has been determined to be safe, effective, and cost-effective for hospitalised patients at venous thromboembolism (VTE) risk. However, Chinese medical institutions have not yet fully utilised or improperly used thromboprophylaxis given the lack of prospective studies; thus, more trials are needed.

Methods

All hospitalised patients aged >18 years not discharged within 24 h from 1 September 2021 to 31 May 2021 were prospectively enrolled. Patients were randomly assigned to the control (9,890 patients) or intervention group (9,895 patients). The control group implemented conventional VTE prevention programmes; the intervention group implemented an Artificial Intelligence Clinical Assistant Decision Support System (AI-CDSS) on the basis of conventional prevention. Intergroup demographics, disease status, hospital length of stay (LOS), VTE risk assessment, and VTE prophylaxis were compared using the chi-square test, Fisher’s exact test, t-test, or Wilcoxon rank-sum test.

Results

The control and intervention groups had similar baseline characteristics. The mean age was 58.32±15.41 years, and mean LOS was 7.82±7.07 days. In total, 5027 (25.40%) and 2707 (13.67%) patients were assessed as having intermediate-to-high VTE risk and high bleeding risk, respectively The incidence of hospital-associated VTE (HA-VTE) was 0.38%, of which 86.84% had DVT. Compared to the control group, the incidence of HA-VTE decreased by 46.00%, mechanical prophylaxis rate increased by 24.00%, and intensity of drug use increased by 9.72% in the intervention group. However, AI-CDSS use did not increase the number of clinical diagnostic tests, prophylaxis rate, or appropriate prophylaxis rate.

Conclusions

AI-CDSS showed a positive role in VTE risk management. Thus, it is necessary to implement evidence-based education programmes to increase physicians’ awareness of thromboprophylaxis and appropriate thromboprophylaxis rates.

Trial registration

This was a randomised controlled single-centre prospective study , which has been reviewed by the World Health Organization International Clinical Trial Registration Platform (11/8/2020, ChiCTR2000035452).
Outcome-adaptive randomisation in a multi-arm breast cancer trial
Authors: Hong Wei , McLachlan Sue-Anne , Moore Melissa , Mahar Robert K.
Published: December 2022

Background
To perform virtual re-executions of a breast cancer clinical trial with a time-to-event outcome to demonstrate what would have happened if the trial had used outcome-adaptive randomisation instead.
Methods
We aimed to retrospectively “re-execute” a randomised controlled trial that compared three chemotherapy regimens for women with metastatic breast cancer (ANZ 0001) using outcome-adaptive randomisation. We used computer simulations to estimate the power and mean number of participants randomised to inferior treatment of a large number of different candidate designs and shortlisted designs with the either highest power or the lowest number randomised to inferior treatment. Using the real-world data, we explored what would have happened had ANZ 0001 been conducted using these shortlisted designs.
Results
We shortlisted seven adaptive randomisation designs that had higher power and a lower number of participants allocated to inferior treatment compared to the original trial design. Adaptive randomised designs were able to reduce the average sample size of the control arm by up to 8.2% when one experimental arm was effective by up to 11.4% when both experimental arms were equally effective. The performance of the adaptive designs when applied to the real-world ANZ 0001 data was consistent with the simulations.
Conclusion
The shortlisted adaptive randomisation designs allocated somewhat fewer participants to inferior treatment while offering the same or better type I and II error rates compared to fixed designs.
Prevalence of hypothyroidism in rheumatoid arthritis and its correlation with disease activity
Authors: jeha Mohamad , jeha Sosana
Published: December 2022

Background: Several recent studies have shown an increased incidence of hypothyroidism in many chronic inflammatory diseases, especially rheumatoid arthritis, and others studies have shown a relationship between hypothyroidism in patients with rheumatoid disease and the degree of disease activity.
Aim of the study: To know the extent of hypothyroidism in a sample of patients with rheumatoid arthritis in Al-Assad and Al-Mowasat University Hospital in Damascus, to link this to the effectiveness of rheumatoid disease, and to compare with a group of healthy controls.
Materials and methods: a cross-sectional/case-control study was conducted on 134 patients diagnosed with rheumatoid arthritis, and a healthy cohort of 134 people from the University Hospitals in Damascus. The presence of hypothyroidism was compared between the two groups of patients and controls. Hypothyroidism in patients was also compared with the disease activity index, after dividing them according to the effectiveness index (DAS28-ESR) into three groups: mild, moderate, and severe disease activity. The data was analyzed using the statistical analysis program (SPSS) version (25) and the variable was considered statistically significant when the P-Value is less than (0.05).
Results: The average age of both patients and controls was (50.6±3.9) and (44.3±2.01) years, respectively. The proportion of females in the sample of patients was (%84.3) and the percentage of females in the control sample (%80.6), the number of patients with hypothyroidism was 43 patients (%32), and the number of infected controls was 10 people (%7.5) P-Value < 0.000. The type of hypothyroidism in patients was classified into clinical hypothyroidism (%67.44) and subclinical hypothyroidism (%32.56). %24.6 of patients and %6 of controls had positive TPO antibodies (P-Value < 0.000). The study has shown a positive correlation between hypothyroidism and disease efficacy indicator (DAS28-ESR).
Conclusion: Increased incidence of hypothyroidism and TPO antibodies in patients with rheumatoid disease compared to healthy subjects, and an increase in the degree of disease activity in patients with rheumatoid disease diagnosed with hypothyroidism compared to patients with rheumatoid disease without hypothyroidism.
A rapid and effective method for obtaining ardicrenin from Ardisia crenata Sims var. bicolor plants
Authors: Lin Zhen , Yang Xiuling , Li Lin , Ma Chunyan , Kong Lingjuan , Li Huancheng , Xiong Shican , Zhong Haiyan , Pu Shangrao , Liang Fang , Hu Ju
Published: December 2022

Ardisia crenata Sims var. bicolor has high ornamental and medical value, especially because it contains the compound ardicrenin, which is a possible alternative drug for Taxol/camptothecin. To protect wild germplasm resources and obtain more ardicrenin, a plant regeneration system was established via calli, and ardicrenin content was quantified by reversed-phase high-performance liquid chromatography (RP-HPLC). The results showed that a Murashige and Skoog (MS) medium with 2,4-dichlorophenoxyacetic acid (2,4-D, 1.0 mg L− 1) and kinetin (KT, 0.01 mg L− 1) was suitable for callus induction, with an induction rate of 95.31 ± 1.62%; a MS medium with 2,4-D (0.5 mg L− 1) and 6-benzylaminopurine (6-BA, 0.2 mg L− 1) was suitable for callus multiplication, with a multiplication coefficient of 359.26; a MS medium with 6-BA (1.0 mg L− 1) and 1-naphthaleneacetic acid (NAA, 0.5 mg L− 1) was suitable for callus differentiation, with a differentiation rate of 89.36 ± 1.39%; and 1/2 MS with indole-3-butyric acid (IBA, 0.2 mg L− 1) was suitable for rooting, with a rooting rate of 93.74 ± 1.38%. Additionally, garden soil: vermiculite: perlite (v: v: v = 1:1:1) was appropriate for acclimatization and transplanting, with a survival rate of 87.38%. RP-HPLC analysis revealed that the ardicrenin content in one-month-old plantlets was higher than that in one-year-old plants and was nearly the same as the content observed in three-year-old plants and two-month-old transplanted plantlets, especially in the roots (17.69 mg g− 1 DW, 1.77% DW). In summary, a rapid propagation system for A. crenata Sims var. bicolor was successfully established for the first time, and the roots of one-month-old plantlets were used to effectively obtain ardicrenin.
Reproductive adverse events in patients with non-Hodgkin lymphoma treated with chemotherapeutic regimens including cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP) or CHOP with rituximab (R-CHOP): A systematic review and meta-analysis
Authors: Han Rong , Zhao Jie , Yu Chengjun , Wang Ling , Chen Long , Hu Yang , Lin Tao , He Dawei , Wei Guanghui , Wu Shengde
Published: December 2022

Introduction: The therapeutic regimen of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or CHOP with rituximab (R-CHOP) is the first-line treatment regimen for non-Hodgkin lymphoma (NHL). NHL patients treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or CHOP with rituximab (R-CHOP) have a high risk of reproductive adverse events. The aim of this systematic review and meta-analysis was to evaluate the reproductive toxicity of this regimen and make further reasonable suggestions on reproductive protection.
Methods: We systematically searched with appropriate terms from January 1980 to June 2021 for observational studies in adult patients who had the risk of reproductive toxicity associated with the CHOP/R-CHOP regimen, without any language or publication-type restriction. We conducted meta-analyses of one-sample proportions of patients suffering reproductive adverse events after using CHOP/R-CHOP. In addition, subgroup analyses were performed to determine the effect of sex.
Result: A total of 9 articles involving 331 patients were included in the meta-analysis, and the pooled proportion of reproductive adverse events was computed to be 22.3% (95% confidence interval [CI] 11.4%–33.2%; heterogeneity test Q=65.3; τ²=0.0231; I²=87.70%; p<0.001) using the random-effects model. A total of 205 male patients were included in this meta-analysis, which used a random-effects model. The pooled proportion of male gonadal toxicity was 29.2% (95% CI 11. 0%– 47.4%; heterogeneity test Q=46.65; τ²=3.055; I²=89.3%; p<0.0001). The pooled proportion of female gonadal toxicity was 16.5% (95% CI 8.5%– 24.5%; heterogeneity test Q=18.6; τ²=0.0112; I²=67.8%; p=0.005).
Conclusion: The findings suggest that NHL patients have a relatively high risk of reproductive adverse events after treatment with CHOP/R-CHOP. Men are more likely to have gonadal damage than women. Evaluation of reproductive function is particularly necessary both before and after treatment. Some reproductive protection strategies implemented for those patients who want to preserve their fertility.
Multiple myeloma and t(11;14): prognostic significance and impact of novel agents on response and survival.
Authors: Puertas Borja , González-Calle Verónica , Sobejano Eduardo , Escalante Fernando , Rey-Bua Beatriz , Padilla Irene , García-Sanz Ramón , Puig Noemí , GUTIERREZ NORMA , Manteca Maria Victoria Mateos
Published: December 2022

Multiple myeloma (MM) patients with t(11;14) present unique biological features and their prognosis is not well established. We report a retrospective study of 591 MM patients, 17.6% of whom had t(11;14). It was designed to determine the prognostic impact of this abnormality and the effect of novel agents on the response and outcomes. Three groups were established based on their cytogenetics: 1) t(11;14); 2) high-risk chromosomal abnormalities; and 3) standard risk (SR). After 80.1 months (1.2-273.8 months) of follow-up, no differences were observed in overall survival (OS) between the t(11;14) and SR groups (75.8 vs. 87.2 months; P = 0.438). However, in ISS-1 stage patients, MM t(11;14) individuals had shorter OS than those in the SR group (62.9 vs. 126.7 months; P = 0.004). Treatment of MM t(11;14) with novel agents did not improve their overall response rate (ORR) or complete response (CR) compared with those who received conventional therapy (ORR: 87.2% vs. 79.5%, P = 0.336; CR: 23.4% vs. 12.8%, P = 0.215). This effect translated into similar PFS (39.6 vs. 30.0 months; P = 0.450) and OS (107.6 vs. 75.7 months; P = 0.175). In summary, MM t(11;14) patients did not benefit from the introduction of novel agents as much as SR patients did, indicating that other therapies are needed if their outcome is to be improved.
Design and Fabrication of Ag 2 O@CuFe 2 O 4 @g-C 3 N 4 Photocatalysts for the Degradation of Organic Dyes Under Visible Light
Authors: WANG Jianhua
Published: December 2022

A new series of Ag2O@CuFe2O4@g-C3N4 composite photocatalyst has been synthesized by a facile one pot hydrothermal reaction approach using urea, g-C3N4, FeCl3 and Cu(AC)2 as precursors. Urea was decomposed over 90oC and adjusted the pH value of reaction solution over 10. In Ag2O@CuFe2O4@g-C3N4−3%, the decomposition rate of MB was 99.93% under visible light within 35 minutes. In the composites, Ag2O and CuFe2O4 have been uniformly dispersed in g-C3N4 matrix, inducing more enhanced efficiency of Ag2O@CuFe2O4@g-C3N4 heterostructure in photo-degradation methylene blue (MB) under visible light. The photocatalytic activity of Ag2O@CuFe2O4@g-C3N4 was enhanced based on the p-n structure between Ag2O, CuFe2O4 and g-C3N4. The decomposition rate of MB was reduced from 99.08–93.59% for several recycling use, thus Ag2O@CuFe2O4@g-C3N4 show high catalytic activity and excellent stability. The photocatalytic mechanism of Ag2O@CuFe2O4@g-C3N4 was discussed based on the active species •OH during photocatalytic process.