bluuebunny/crossref_metadata_2025 huggingface dataset:
Paziente con scompenso cardiaco: cosa aggiunge la risonanza magnetica cardiaca?
Authors: Leo Isabella , Scatteia Alessandra , Torella Daniele , Dellegrottaglie Santo
Published: April 2024

Nonostante i progressi nella prevenzione, diagnosi e trattamento, lo scompenso cardiaco rimane una condizione ad alta morbidità e mortalità. L’imaging cardiovascolare è uno step essenziale nel processo diagnostico e terapeutico. In particolare, la risonanza magnetica cardiaca (RMC) risulta fondamentale, offrendo non solo un’accurata misurazione dei volumi e della funzione cardiaca ma anche una caratterizzazione tissutale dettagliata. Accanto al ruolo diagnostico, con la possibilità di discriminare tra le differenti eziologie sottostanti la disfunzione cardiaca, la RMC ha un ruolo crescente nella stratificazione del rischio e nella valutazione prognostica. In questo documento verrà descritto il ruolo della metodica nel paziente affetto da scompenso cardiaco.
A protocol for tissue clearing and three-dimensional imaging of human sigmoid mucosal biopsies v2
Authors: Yuan Pu-Qing , Li Tao , Taché Yvette
Published: April 2024

This protocol was developed for tissue clearing and 3D imaging of human sigmoid mucosal biopsies by adapting and modifying the original CLARITY tissue clearing technique/immunofluorescence protocols that we established for 3D imaging and phenotyping of human colonic enteric nervous system.By using this new protocol, a piece of entire human sigmoid mucosal biopsy specimen with the volume about 6x3x1-2 mm (length x wide x thickness) can be completely cleared within 3-4 days. The 3D images and videos generated from cleared biopsy samples showed clear spatial views of nerve innervation, distributions of mast cells and enteric glial cells, and configurations of mast cells with nerve fibers in the sigmoid colonic mucosa.
Pengaruh Latihan Drill Terhadap Kemampuan Servis Backhand Bulutangkis Mahasiswa
Authors: Apriliani Alma , Arifin Zaenal , Sonjaya Azhar Ramadhana
Published: April 2024

This research was motivated by the high number of short backhand servis errors made by badminton athletes who took part in activities at the Garut University Student Activity Unit, Physical Education class of 2019. One of the factors identified as the cause of these errors was the athlete's poor foot position when making the shot. . Therefore, improvement is needed through continuous training, one of which is by using drill exercises. The problem formulation for this research is whether there is an effect of drill training on backhand servis ability, with the aim of assessing the impact of drill practice on badminton athletes' backhand servis ability.The concepts and theories used as references include training concepts, training principles, drilling practice concepts, and badminton game concepts. The results of the research show that there is a positive influence of drill training on backhand servis ability. This is proven by an increase in the average value of the backhand serve after participation in drill practice. Statistical analysis produces a calculated t value = -20.716 and t table = -2.160, with -t calculated -t table (-20.716 -2.160). Apart from that, the probability value (P value) 0.05 or 0.000 0.05, so the null hypothesis (Ho) is rejected. This means that there is a significant difference in backhand servis ability before and after drill practice.Recommendations for this research were given to the UNIGA Student Activity Unit (UKM) Manager to improve the management of UKM activities, the Badminton UKM Manager to improve the quality and quantity of training, and to the campus to further improve the guidance of UNIGA UKM as an implementation of the Tri Darma of Higher Education.
Urgency of Addressing the Problem of State Ideology: Divergent Perspectives from Scholars and Politicians
Authors: Okhotsky Evgeny V.
Published: April 2024

Throughout its centuries-long history, Russia has repeatedly attempted to define its historical purpose, determine the course and strategy of sociopolitical development, and articulate the value preferences guiding its society. It is evident that addressing such a complex undertaking, burdened with profound objectives, necessitates an appropriate framework of ideas, perspectives, and theories. This article substantiates the possibility, necessity, and practical significance of a state ideology, while also questioning the relevance, in contemporary historical conditions, of maintaining the constitutional prohibition on a state or mandatory ideology. Russia possesses an ideology of statehood, with its main substantive components enshrined in the country’s Constitution, relevant legal statutes, annual presidential addresses to the Federal Assembly, and relevant programs, doctrines, and other political documents. Central to this ideological framework is the concept of a federal democratic legal social secular state harmoniously integrated with the traditional ideals, values, and priorities of Russian civilization. This study adopts a comparative institutional and functional approach.
Fetvalar ve Türk Hukukundaki Emsal Kararların İşlev Benzerlikleri Ve Temel Farklılıkları
Authors: Gökçen Fezanur
Published: April 2024

Bu makalenin konusu, tez çalışmalarımız sırasında fetvalar ile Türk hukukunda yer alan emsal kararların işlev olarak birbirine oldukça benzediğini fark etmemiz üzerine ortaya çıkmıştır. Mer’i hukukta emsal karar denilen bir olgu vardır. Emsal karar, benzer hukuki uyuşmazlıklarda örnek olarak uygulanabilme serbestisidir. Yargıtay ve Danıştay kararlarının emsal karar olma özelliği oldukça yüksektir. Taraflar henüz görülmekte olan bir davada mahkemeden lehlerine karar çıkabilmesi için benzer davalarda daha önce verilmiş kararları örnek olarak mahkemeye sunabilme olanağına sahiptir. Mahkemenin hâkimi de emsal karara dayanarak hüküm verebilmektedir. Fetvaların da Osmanlı hukukunda böyle bir işlevi vardır. Osmanlı mahkemelerine başvurmadan önce veya dava sırasında taraflar ilgili konuda daha önce verilmiş bir fetvaya dayanarak veya dava için özel olarak müftîden fetva isteyerek kâdıya sunma imkanına sahip idi. Aynı şekilde kâdı da kendisine gelen bu dava için müftîye danışıp fetva isteyebilmekteydi. Bu makale günümüz hukukunda yer alan emsal kararlar ile Osmanlı hukukunda fetvaların hem mahkemede tarafların lehine ve aleyhine delil olabilmesi bakımından hem de mahkemeyi gören hâkimin ve kâdının hüküm verirken dikkate alması bakımından aynı işlev ile kullanıldığını iddia etmektedir. Bu iddianın temelinde ise Ali Himmet Berki’nin “İslam’da Kaza” eserinde ortaya koyduğu fetvalar ve emsal kararların aynı amaçla derlendiği iddiası yer almaktadır. Bu iddiadan hareketle fetvalar ve emsal kararların sadece aynı amaçla derlendiği değil aynı zamanda mahkemelerde aynı işlevde de kullanıldığı ortaya konulmaya çalışılacaktır. Bu nedenle sicillerde mahkeme kararlarına örneklik teşkil eden fetvalar mer’i hukuktaki emsal kararlar ile mukayese edilip mahkemenin hükme bağlanmasındaki etkisi ortaya konulacaktır. Bu amaçla 18.yy İstanbul ve Diyarbakır Sicilleri kaynak olarak kullanılacaktır. Bu sicillerde yer alan davalarda tarafların hangi fetvaları mahkemeye sundukları ve mahkemenin bu fetvaları dikkate alıp almadığı üzerinde durulacaktır. Aynı zamanda mer’i hukuktaki emsal kararlar da bu bakımdan incelenecektir. Bu işlev benzerliğinin yanı sıra bu iki hukuki olguyu temelden ayıran farklılıklar da bulunmaktadır. Bu metinde işlev benzerlikleri örneklerle zikredildikten sonra aralarındaki farklar da maddeler halinde listelenecektir. Böylece fetva ve emsal karar arasındaki işlev uyumu örnekler üzerinden ortaya konulacak ve aralarında var olan farklılıklar da gün yüzüne çıkmış olacaktır.
The long-term results of proximal interphalangeal joint arthroplasty of the hand
Authors: Fedotov P. V. , Kovalev D. V. , Rybakov S. N.
Published: April 2024

Introduction Small joints replacement is a valid treatment for deforming osteoarthritis and traumatic injuries to  the  phalangeal joints of the hand to restore motor hand functions. Various types of implants differing in shape, biomechanics and material composition have been developed.

The purpose of the study was to evaluate long-term results of the proximal interphalangeal joint arthroplasty of the hand using various implants and identify their advantages.

Material and methods We retrospectively reviewed 78 cases of proximal interphalangeal joint replacement in 64 patients. Outcomes were assessed at 6 months and at follow-up stages with preoperative and postoperative measurements of the range of motion in the joint evaluating pain, radiographs and outcomes measures using the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire.

Results The range of motion in the prosthetic joint increased significantly at different follow-up periods with all types of implants. The pain syndrome decreased. Radiographs revealed 10 cases of aseptic instability in  the  group of constrained prostheses. The DASH assessment showed high subjective satisfaction with the treatment.

Discussion We could not find papers reporting PIP joint arthroplasty using SBI D.G.T. implant system. A retrospective study of RM Finger arthroplasty of the PIP joint indicated restored joint stability with AROM improvement and with low pain, although it had a high rate of complications. We recorded no complications with this implant model. Some authors would not recommend the RM Finger implant (Mathys) for PIP joint replacement. Arthroplasty of small joints of the hand with MOJE kermik-implantate showed satisfactory outcomes for 82 % of patients at a long term.

Conclusion Arthroplasty of the PIP joint of the hand using various implant designs resulted in greater mobility of the upper limbs, a lower pain due to subjective improvement in the functionality at a long term. Although the procedures were effective with all implant designs the reliability of changes in the parameters was more evident with nonconstrained implants.
Validation and evaluation of the Russian version of the SEFAS questionnaire for assessing foot and ankle in surgically treated patients with forefoot disorders
Authors: Akulaev A. A. , Ivanov A. A. , Ionova T. I. , Nikitina T. P. , Tishchenkov K. A. , Povaliy A. A.
Published: April 2024

Introduction The Self-reported Foot and Ankle Score (SEFAS) is one of the foot health assessment tools in Sweden. Validation procedures, reliability, validity, sensitivity, approval are essential for the Russian version of the questionnaire with a new language environment.

The objective was to validate the Russian version of the SEFAS questionnaire and approve the tool in the Russian surgical patients with foot disorders.

Material and methods The questionnaires the patients completed preoperatively included SEFAS, SF‑36, a general health survey questionnaire, and the Lower Extremity Functional Scale (LEFS). Patients were requested to  complete the SEFAS questionnaire at 2 months of surgery to assess the sensitivity of the instrument. Based on the case histories clinical researcher recorded general and physical parameters of the patients to include gender, age, socio-demographic data, nature of the foot disorder, a dorsiflexion angle of  the  first metatarsophalangeal joint. To  assess the reproducibility of  the  Russian version of the questionnaire, some patients were requested to complete the SEFAS questionnaire twice preoperatively with an interval of one day.

Results The questionnaire was characterized by good internal consistency and reproducibility indicating acceptable reliability of the Russian version of SEFAS. Statistically significant correlations of varying strength were seen between the SF-36 scores and nearly all the selected questions of the SEFAS Russian version. Statistically significant correlations (moderate to weak) were observed between the LEFS total score and the selected SEFAS questions. Minimal clinically significant changes in MCID scored 3 in the assessment of clinical interpretability of the Russian version of SEFAS.

Discussion The study demonstrated the reliability, validity and sensitivity of the Russian version of the SEFAS questionnaire. The questionnaire appeared to be an informative and clinically interpretable instrument for assessing foot in surgical adult patients with foot disorders.

Conclusion The SEFAS questionnaire can be recommended for Russian trauma and orthopaedic practice to learn the patient's opinion of the condition.
Current state of the treatment problem in the patients with elbow joint contractures due to ossification
Authors: Petlenko I. S. , Shubnyakov I. I. , Fedyunina S. Yu. , Aliyev A. G. , Bilyk S. S. , Ryabinin M. V.
Published: April 2024

Introduction Surgical treatment of stiff elbow caused by ossification often result in poor outcomes due to anatomical and physiological characteristics, significant functional load and higher patient requirements for the elbow functionality.

The purpose was to determine ways of improved surgical treatment for patients with elbow contractures caused by ossification, based on an analysis of literature reporting surgical strategy and outcomes.

Material and methods An internet search of PubMed, Medline, Elibrary.ru, CyberLeninka, Google Scholar, International Clinical Trials Registry of the US National Institutes of Health, ISRCTN Registry of International Standard Randomized Clinical Trial Numbers, German Clinical Trials Registry DRKS, WHO Registry was performed. Search words and phrases included elbow contracture, ossification, surgical treatment, stiff, elbow, surgical treatment, ossification. The search depth was 10 years.

Results and discussion Some important parameters (recurrence of stiffness, pain, decreased quality of life, etc.) are reported as “very unassertive” in patients with stiff elbow due to ossification at mid and long terms (12–24 months or greater). Poor outcomes are reported in approximately 50 % of the cases due to the range of  motion decreased to the preoperative level or less. Many patients (more than 90 % according to some authors) need a repeated surgery and are at risk for the stiff joint.

Conclusion A critical analysis of the literature indicates lack of preoperative instrumentation examination of patients with use of new visualization methods (3D modeling). Preoperative examination and surgical planning based on additive technologies are essential for surgically treated patients with stiff elbow caused by ossification.
Lumbosacral transitional vertebrae in children and adolescents (literature review, illustrated with clinical observations)
Authors: Skryabin E. G. , Krivtsov A. Yu. , Kicherova O. A. , Klokov I. N. , Zotov P. B. , Akselrov M. A.
Published: April 2024

Introduction An analysis of the medical literature devoted to various aspects of transitional lumbosacral vertebrae shows that there are very few publications covering the course of this disease in  the  pediatric and adolescent population.

Aim To study the issues of epidemiology, diagnosis, treatment and prevention of transitional lumbosacral vertebrae in paediatric and adolescent patients based on the analysis of current medical literature and illustrate the material with our own clinical observations.

Material and methods To analyze the literature on the topic, 75 papers published between 1984 and 2023 were selected. Among them, there were 7 (9.3 %) domestic literary sources, 68 (90.7 %) were foreign. In the process of searching for scientific articles, the resources of the electronic databases of current medical information PubMed and CyberLeninka were used.

Results and discussion The incidence of transitional vertebrae in children and adolescents is 16.8 % of clinical observations, as reported. In the structure of the transitional vertebrae in children, type II of  the  disease predominates according to the classification Castellvi et al (1984), 43.2 % of cases. The main clinical symptom of the pathology is pain of lumbosacral location, the intensity of which on the visual analog scale in children corresponds to an average of 3.0 points. In adult patients with similar pathology, the average pain intensity measured with the same scale is 7.5 points. The most informative method for  diagnosing the  disease is computed tomography, which allows obtaining both 3D images and sections at the level of pseudarthrosis between the enlarged transverse process (or processes) of the suprasacral vertebra and the wing of the sacrum. To  relieve pain in children with transitional vertebrae, both conservative and surgical methods are used. The most commonly used procedure is pseudarthrectomy. The study of  long-term results one year after the intervention allowed us to record the absence of pain in children who underwent surgery. Prevention measures for transitional lumbosacral vertebrae have not been developed.

Conclusion The analysis of the published literature shows that transitional vertebrae are a frequently diagnosed pathology in children and adolescents. Current methods of imaging are able to accurately detect not only the  presence of the disease, but also to differentiate its type. The main clinical symptom of  transitional vertebrae is pain in the lumbosacral spine which is difficult to relieve with conservative therapy. Pseudarthrectomy is the most frequent surgical method of treatment in children and adolescents that provides stable relief of vertebrogenic pain syndrome. Measures for specific prevention of the disease have not been developed.
Evolution of the first metatarsophalangeal joint replacement
Authors: Kotelnikov G. P. , Nikolaenko A. N. , Grankin I. O. , Ivanov V. V. , Isaykin P. Yu. , Doroganov S. O. , Zgirsky D. O.
Published: April 2024

Introduction The diseases of the first metatarsophalangeal (1 MTP) joint that require surgical treatment include osteoarthritis (69 %), rheumatoid arthritis (26 %), tumors, tumor-like diseases and purulent arthritis (5 %). The treatment of arthritic 1 MTP is aimed at reducing pain and improving function. Joint replacement implants are meant to support body weight, maintain the length of the first metatarsal, provide metatarsal‑sesamoid joint functioning and restore joint motion. The purpose of the work was to analyze data from foreign and domestic literature on endoprosthetics of the 1 MTP, and briefly present analytical data on the results of using various implants.

Material and methods The article presents the summary of the Russian and foreign publications on  1 MTP joint replacement. The original literature search was conducted on key resources including PubMed, eLIBRARY, MedLine, Scopus. The search strategy was comprised of keywords: “replacement of  the  first metatarsophalangeal joint”, “surgical treatment of hallux rigidus”, “osteoarthrosis of the first metatarsophalangeal joint”, “results of endoprosthetics of the 1st metatarsophalangeal joint”, "modernization of implants of the 1st metatarsophalangeal joint". Publications brought out between 1968 and 2022 inclusive were analyzed.

Results and discussion The ideal implant should restore functional range of motion, improve function, maintain joint stability, distribute the stress across joint surfaces being wear-resistant. Over the years, various materials have been used to provide simple and reliable designs. Implants have been improved and divided into groups based on material and design, limited degrees of freedom, tribological pair composition, and the amount of articular surface replacement.

Conclusion New generation implants have a more durable design, anatomical shape and improved osseointegration. The advances in joint replacement have resulted in greater patient satisfaction and increased service life. The complication rate for replacement of the 1 MTP joint remains high. This indicates the need for continued research and further work to improve implants to make them more effective and easier to use.
Autotutela ejecutiva de la Administración
Authors: Calvo Rojas Eduardo
Published: April 2024

Ponencia presentada en el seminario anual entre la Revista de la Administración Pública y la Sala de lo Contencioso-Administrativo del Tribunal Supremo. En el texto se hace una breve exposición sobre las prerrogativas de autotutela de la Administración, incidiendo en la relación secuencial que existe entre la autotutela declarativa y la ejecutiva; y se hacen comentarios específicos sobre vía de hecho, los límites a la autotutela ejecutiva y los diferentes medios de ejecución forzosa, todo ello con cita de la más reciente jurisprudencia referida a esas cuestiones.
La adjudicación de espacios comerciales en los aeropuertos: a propósito de los alquileres de AENA
Authors: Guimerá Rico Juan José
Published: April 2024

n el presente trabajo se aborda la naturaleza jurídica de la adjudicación de locales destinados a actividades comerciales en los aeropuertos. Tradicionalmente autorizaciones demaniales, la liberalización del sector trajo consigo la desafectación parcial del dominio público aeroportuario y su gestión mediante contratos de arrendamiento, negocios patrimoniales excluidos de la legislación de contratos públicos. Esto plantea el problema del control del cumplimiento de los principios de publicidad, transparencia, objetividad y concurrencia en la explotación de bienes patrimoniales, problema que la STS 317/2021, de 8 de marzo, resolvió considerándolos contratos de concesión de servicios. Aunque no ha sido reiterada, las dudas que plantea justifican un intento de revisión del régimen aplicable. A tal fin, se analizan la jurisprudencia clásica sobre estos negocios, sus particularidades en el sector aeroportuario, la incidencia de las directivas y las dificultades de su transposición al derecho interno.
On one solution of the problem of vibrations of
mechanical systems with moving boundaries
Authors: Litvinov V. L. , Litvinova K. V.
Published: April 2024

An analytical method of solving the wave equation describing the oscillations of systems with moving boundaries is considered. By changing the variables that stop the boundaries and leave the equation invariant, the original boundary value problem is reduced to a system of functional-difference equations, which can be solved using direct and inverse methods. An inverse method is described that makes it possible to approximate quite diverse laws of boundary motion by laws obtained from solving the inverse problem. New particular solutions are obtained for a fairly wide range of laws of boundary motion. A direct asymptotic method for the approximate solution of a functional equation is considered. An estimate of the errors of the approximatemethod was made depending on the speed of the boundary movement.
On the boundary conditions for a thin circular plate
conjugated to a massive body
Authors: Ustinov K. B. , Gandilyan D. V.
Published: April 2024

The problem of deformation under the action of uniform pressure of a circular plate coupled with a massive base is considered, while the condition for the coupling of the plate with the base is modeled using boundary conditions of the generalized elastic embedding type, i.e. the relationship between the bending moment and forces at the edge of the plate with displacements and rotation angles through the compliance matrix. The main goal of the work is to study the influence of the elasticity of the embedding on the elastic response of the plate. The solution to the problem was obtained in the formulation of the linear theory of plates, the theory of membranes in the approximation of homogeneity of longitudinal forces, and the Foppl — von Karman theory, also in the approximation of the assumption of homogeneity of longitudinal forces. The values of the coefficients of the compliance matrix were obtained using the finite element method for the auxiliary problem and compared with the values of the coefficients obtained for related problems by analytical methods. Numerical results were obtained for an aluminum wafer on a silicon base. The obtained solution was compared with the solution obtained for the rigid embedment condition for all three models used. It is shown that in the case of large deflections (several plate thicknesses), taking into account the compliance of the embedment becomes essential.
Hemşirelerin Algıladığı Örgütsel Desteğin ve Temel Benlik Değerlendirmesinin İşe Tutkunluk Üzerindeki Etkisinde İş Becerikliliğinin Aracılık Rolü
Authors: Seçkin Şeyda Nur , Çağlın Cahit
Published: April 2024

Bu çalışmada hemşirelerin algıladığı örgütsel desteğin (AÖD) ve temel benlik değerlendirmesinin (TBD) işe tutkunluk üzerindeki etkisinde iş becerikliliğinin aracılık rolünün belirlenmesi amaçlanmıştır. Şırnak ilindeki devlet hastanelerinde görev yapan hemşireler, mevcut çalışmanın ana kütlesini oluşturmaktadır. Basit tesadüfi örnekleme yöntemiyle 249 hemşireyle anket çalışması yürütülmüştür. Elde edilen veriler SPSS, AMOS ve PROCESS Macro programlarında kullanılmak üzere kodlanmıştır. Yapılan analizler neticesinde hemşirelerin AÖD’in ve TBD’sinin iş becerikliliklerini ve işe tutkunluklarını olumlu yönde etkilediği; AÖD’in ve TBD’sinin işe tutkunlukları üzerindeki etkisinde iş becerikliliklerinin kısmi aracılık rolünün olduğu belirlenmiştir.
Antileukemia Activity of Human Natural Killer Cell-Derived Nanomagic Bullets against Acute Myeloid Leukemia (AML)
Authors: Khatib Zahra Kashani , Maleki Asma , Pourfatollah Ali Akbar , Hamidieh Amir Ali , Ferdowsi Shirin
Published: April 2024

Background: Cancer is among the serious health problems of the medical world, for treatment of which severe treatments are used. However, the prognosis of cancer patients is still poor. The application of NK cell-derived exosomes (NK-Exo) is a new method for cancer immunotherapy. These nanoparticles with a size range of 30-120 nm are a small model of mother cells. In this study, the anti-tumor activity of NK-Exo and LAK-Exo (activated NK cell-derived exosome) against acute myeloid leukemia (AML) is investigated in vitro.
Materials and Methods: The MACS method was performed for the separation of NK cells from the buffy coats of healthy donors, and an EXOCIBE kit was used for the isolation of NK-Exo. After treating the KG-1 cell line with different doses of NK-Exo, MTT assay, and annexin V-PE were done to evaluate cell proliferation and apoptosis, respectively, and for confirmation of involved proteins, Real-Time PCR and western blotting were performed.
Results: Anti-tumor activity of NK-Exo and LAK-Exo was dose- and time-dependent. Their highest activities were observed following 48 hours of incubation with 50 µg/ml exosome (p<0.0001). However, this cytotoxic activity was also seen over a short period of time with low concentrations of NK-Exo (p<0.05) and LAK-Exo (p<0.001).The cytotoxic effect of LAK-Exo on target cells was significantly higher than NK-EXO. The induction of apoptosis by different pathways was time-point dependent. Total apoptosis was 34.56% and 51.6% after 48 hours of tumor cell coculture with 50µg/ml NK-Exo and LAK-Exo, respectively. Significant expression of CASPASE3, P38, and CYTOCHROME C genes was observed in the cells treated with 50 µg/ml NK-Exo and LAK-Exo.
Conclusion: Our study confirmed the antileukemia activity of NK-Exo against AML tumor cells in vitro. Therefore, NK-Exo can be considered as a promising and effective treatment for leukemia therapy.
Effect of Melissa officinalis on Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Randomized Trial
Authors: Ehsani Zohreh , Salehifar Ebrahim , Habibi Emran , Alizadeh-Navaei Reza , Moosazadeh Mahmoud , Tabrizi Nasim , Zaboli Ehsan , Omrani-Nava Versa , Shekarriz Ramin
Published: April 2024

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a significant cancer treatment side effect that can influence both quality of life and treatment course. Melissa Officinalis (MO), due to its high content of flavonoids, has antioxidant, anti-inflammatory, and neuroprotective properties. 
Materials and Methods: The cancer patients diagnosed with CIPN attended a referral center in Sari (Iran). The hydroalcoholic extract of MO leaves was extracted by the maceration method. The control group received a placebo along with gabapentin as the standard treatment, and the intervention group received 500 mg Melissa officinalis 2 times daily for 3 months plus gabapentin. Patients were evaluated at the baseline and 3 months later, according to Common Terminology Criteria for Adverse Effects (CTCAE) and EORTC QLQ-C30 (Integrated System for Quality of Life Assessment). 
Results: A total of 40 patients were considered as group D (intervention group), and 35 patients completed the study. Out of 40 subjects in the placebo group (P), 3 patients could not tolerate the drug due to gastrointestinal disturbances. The final values of CTCAE showed a statistically significant difference (p=0.010). Indicators related to the quality of life in both groups showed a significant improvement. In the intervention group, the pain perception and diarrhea experience were significantly reduced.
Conclusion: Quality of life indicators were improved by prescribing gabapentin with and without Melissa officinalis. The addition of Melissa officinalis to the chemotherapy regimen may improve diarrhea and pain perception.
Silibinin, Synergistically Enhances Vinblastine-Mediated Apoptosis in Triple Negative Breast Cancer Cell Line: Involvement of Bcl2/Bax and Caspase-3 Pathway
Authors: Dariushnejad Hassan , Roshanravan Neda , Wasman Hunar Mustafa , Cheraghi Mostafa , Pirzeh Lale , Ghorbanzadeh Vajihe
Published: April 2024

Background: Triple-negative breast cancer (TNBC) with a poor prognosis and survival is the most invasive subtype of breast cancer.  Usually, TNBC requires a chemotherapy regimen at all stages, but chemotherapy drugs have shown many side effects. We assumed that combination therapy of vinblastine and silibinin might reduce the vinblastine toxicity and dose of vinblastine.
Materials and Methods: The MDA-MB-231 were cells subjected to MTT assay for IC50 determination and combination effects, which were measured based on Chou-Talalay's method. The type of cell death was determined by using a Flow-cytometric assay. Cell death pathway markers, including Bcl-2, Bax, and caspase-3 were analyzed by western blot and Real-Time PCR.
Results: The treatment of MDA-MB-231 cells exhibited IC50 and synergism at the combination of 30 µM of silibinin and 4 µm of vinblastine in cell viability assay (CI=0.69). YO-PRO-1/PI double staining results showed a significant induction of apoptosis when MDA-MB-231 cells were treated with a silibinin and vinblastine combination (p<0.01). Protein levels of Bax and cleaved caspase-3 were significantly upregulated, and Bcl-2 downregulated significantly. Significant upregulation of Bax (2.96-fold) and caspase-3 (3.46-fold) while Bcl-2 was downregulated by 2-fold.
Conclusion: Findings established a preclinical rationale for the combination of silibinin and vinblastine. This combination produces synergistic effects in MDA-MB-231 cells by altering pro- and anti-apoptotic genes, which may reduce the toxicity and side effects of vinblastine.
Hemoglobin C Disorder in Anemic Patients Referred to the National Center for Thalassemia and Genetic Counseling in Damascus
Authors: Ahmad Aya , Fattoum Karam , Imam Wael , Mukhalalaty Mhd Yasser , Murad Musab , Al Quobaili Faizah Ali
Published: April 2024

Background: Hemoglobinopathies are common inherited blood disorders in our Mediterranean area. The main structural hemoglobin variants are hemoglobin S and hemoglobin C, due to their prevalence.
We conducted this retrospective study to investigate and characterize hemoglobin C patients referred to the National Center for Thalassemia and Genetic Counseling and the management of hemoglobin C disease in Damascus.
Materials and Methods: The study included patients referred to the National Center for Thalassemia and Genetic Counseling in Damascus between 2000 and 2022 for hemoglobin C detection. Gender, age, geographical origin, hemoglobin electrophoresis profile, and blood transfusion were considered for hemoglobin C patient classification. Blood transfusion in five consecutive years and linear regression with hemoglobin S and C values were determined.
Results: 30 (14 males and 16 females) out of 624 patients between 3 and 46 years old (mean ± SD: 17.3 ± 9.7 years) showed hemoglobin C disease. Only eight patients (one male and seven females) received blood transfusions, and the remaining patients (13 males and 9 females) did not receive any transfusion. Only one patient with 100% hemoglobin C was detected; 19 showed HbSC, and 10 had HbAC. There was a significant correlation between hemoglobin S and geographical origin (P-value=0).
Conclusion: A Homozygote hemoglobin C patient has mild hemolytic anemia, whereas the hemoglobin C 100% patient has only a one-time blood transfusion (he was 17 years old) in our study. The inherited combination of hemoglobin C and S is less severe than hemoglobin S alone. There is a significant relationship between hemoglobin S and geographical origin (p-value=0).
A Case of Deep Venous Thrombosis in an HIV-Infected Patient despite Therapeutic Anticoagulation
Authors: Aiman Wajeeha , Ashar Ali Muhammad , Grewal Navjot , Bethel Nyan , Savopoulos Andreas A. , Guron Gunwant
Published: April 2024

Patients with human immunodeficiency virus (HIV) infection have an increased likelihood of venous thromboembolism (VTE) owing to factors such as acquired protein C and S deficiency, antiphospholipid antibody syndrome, and heightened levels of pro-inflammatory cytokines. This case report highlights an exceptionally uncommon occurrence of deep venous thrombosis in an HIV-infected patient receiving a therapeutic dose of enoxaparin. This underscores the need for cautious consideration of the risk of VTE in HIV-infected individuals, even with preventive or therapeutic anticoagulant treatment. Further research is recommended to investigate HIV as a potential risk factor of prophylactic anticoagulation.
The Role of Digitalization in Enhancing Legal Competencies of Sharia Economic Law Graduates: A Case Study of graduate users in South Kalimantan
Authors: Rahmaniah Amelia , Luthfi Fuad , Haris Muhammad
Published: April 2024

Abstract: This study aims to identify the needs of graduate users and also show the strategies adopted by the Sharia Economic Law Study Program at Antasari State Islamic University in designing innovative curriculum and learning processes to produce graduate standards that are under the needs and desires of users. The informants in this study were graduate users who were selected based on the criteria of having alumni working in both government and non-government (private) agencies in South Kalimantan. The results showed that the needs of graduate users of the Sharia Economic Law Study Program include integrity, professionalism, foreign language skills, information technology skills, communication skills, cooperation skills, and self-development skills. In addition, the integration of technology in the learning process has also increased efficiency and effectiveness in transferring legal knowledge and skills to students.Keywords: Legal Competence, Sharia Economic Law, Graduate Users, Science Integration. Abstrak: Penelitian ini bertujuan untuk mengidentifikasi kebutuhan pengguna lulusan dan juga menunjukkan strategi yang ditempuh oleh Program Studi  Hukum Ekonomi Syariah Universitas Islam Negeri Antasari dalam merancang kurikulum dan proses pembelajaran inovatif untuk menghasilkan standar lulusan yang sesuai dengan kebutuhan dan keinginan para pengguna. Informan dalam penelitian ini adalah para pengguna lulusan yang dipilih berdasarkan kriteria adanya alumni yang bekerja baik di instansi pemerintah dan non pemerintah (swasta) yang ada di Kalimantan Selatan. Hasil penelitian menunjukkan bahwa kebutuhan pengguna lulusan terhadap Program Studi Hukum Ekonomi Syariah meliputi integritas, profesionalisme, kemampuan bahasa asing, kemampuan teknologi informasi, kemampuan komunikasi, kemampuan kerjasama, dan kemampuan pengembangan diri. Selain itu, integrasi teknologi dalam proses pembelajaran juga telah meningkatkan efisiensi dan efektivitas dalam mentransfer pengetahuan dan keterampilan hukum kepada mahasiswa.Kata Kunci: Kompetensi Hukum, Hukum Ekonomi Syariah, Pengguna Lulusan, Integrasi Ilmu.
Legal Consequences For A Notary Public With Double Professions As A Rector Of A Private University Based On Law On Office Of Notary Public
Authors: Effendy Jaraputri Rabi'ah Adawiyah Phonna , Rahayu Sri Walny , Din Mohd. , Ghifari Muhammad Suhail
Published: April 2024

Abstract: This research discusses juridical consequences for a notary with double professions as a rector of a private university according to Law on office of notary public. The purpose of this research is to explore and analyze the juridical consequences and sanctions for a notary with double professions as a rector or lecturer of a private university according to Law on office of notary public and code of ethics. This is normative legal research. This research shows that Article 17 Letter f of UUJN explicitly mentions the prohibition for a notary to has double professions as a manager or an employee of a State-owned Enterprise, a Municipally-owned Corporation, or a private company. A notary public who becomes a rector or lecturer at a private university is not assumed to violate the provision of Article 17 letter f UUJN. However, a notary with double professions can get administrative sanction in the form of a written warning, temporary layoff, honorably or dishonorably discharge.Keywords: Doubling for a notary; Rector of Private University  Abstrak: Penelitian ini membahas mengenai konsekuensi yuridis bagi notaris yang merangkap jabatan sebagai pimpinan perguruan tinggi swasta menurut undang-undang jabatan notaris. Penelitian ini bertujuan untuk mengkaji dan menganalisis mengenai konsekuensi yuridis serta penerapan sanksi bagi notaris yang merangkap jabatan sebagai pimpinan atau dosen di perguruan tinggi swasta menurut undang-undang jabatan notaris dan kode etik. Jenis Penelitian ini ialah penelitian yuridis normatif. Hasil Penelitian menunjukkan bahwa dalam Pasal 17 huruf f UUJN secara eksplisit disebutkan bahwa adanya larangan bagi pengemban profesi Notaris untuk merangkap jabatan sebagai pemimpin atau pegawai BUMN, BUMD atau badan usaha swasta. Seseorang yang mengemban jabatan Notaris menjadi pimpinan dan dosen pada Perguruan Tinggi Swasta tidak melanggar ketentuan Pasal 17 huruf f UUJN. Serta terkait notaris yang melakukan rangkap jabatan dapat dikenakan sanksi administratif berupa peringatan tertulis, pemberhentian sementara, pemberhentian dengan hormat atau tidak hormat.Kata Kunci: Rangkap Jabatan Notaris, Pimpinan Perguruan Tinggi Swasta.
Podjetniška demografija in značilnosti podjetništva mladih: Slovenski podjetniški observatorij 2023
Authors: Širec Karin , Bradač Hojnik Barbara , Močnik Dijana
Published: April 2024

V okviru Slovenskega podjetniškega observatorija 2023 smo proučevali demografijo slovenskih podjetij in značilnosti podjetništva mladih v Sloveniji in primerjalno z Evropo. Kot vsako leto, smo tudi tokrat v prvem delu raziskave Slovenskega podjetniškega observatorija analizirali demografske značilnosti slovenskih podjetij, medtem ko smo drugi del posvetili aktualni temi tako v slovenskem kot evropskem gospodarstvu, analizi podjetništva mladih. Demografska analiza je bila usmerjena v razumevanje profilov slovenskih podjetij na podlagi različnih kriterijev, kot so število podjetij, njihova velikost, ustvarjen prihodek, stroški dela in dodana vrednost, razčlenjeno po dejavnosti, regiji in velikosti podjetja. Proučevanje značilnosti podjetništva mladih je zagotovilo vpogled v dinamiko podjetništva v izbrani ciljni skupini z namenom oblikovanja učinkovitih ukrepov spodbujanja razvoja podjetništva mladih.
Self-Rated Health and Medically Diagnosed Chronic Disease Association among Adults in Puerto Rico
Authors: Gago Cristina , O’Neill H. June , Tamez Martha , López-Cepero Andrea , Rodríguez-Orengo José F. , Mattei Josiemer
Published: April 2024

Introduction

Latinos report lower self-rated health (SRH) than non-Hispanic White persons. However, the association between SRH and medically diagnosed chronic diseases (MDCDs) remains understudied in Latino populations. This study assessed the relationship between a single-item SRH indicator and MDCD status among predominantly Latino adults in Puerto Rico.

Methods

Participants (30–75 years; n=965) of the Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic Disease Trends (PROSPECT) reported SRH (excellent/very good, good, or fair/poor) and MDCD (ever vs never). We performed multivariate logistic regressions to evaluate the association between SRH and MDCD, which adjusted for key socioeconomic, demographic, and behavioral confounders.

Results

Twenty-seven percent of participants reported excellent/very good SRH, 39% good, and 34% fair/poor. Participants with fair/poor SRH (vs excellent/very good) were more likely to report MDCD for painful inflammation (odds ratio [OR]=4.95 [95% CI, 3.27–7.48]), kidney disease (4.64 [2.16–9.97]), sleep disorder (4.47 [2.83–7.05]), migraine headaches (4.07 [2.52–6.58]), overweight/obesity (3.84 [2.51–5.88]), depression (3.61 [2.28–5.74]), hypertension (3.59 [2.43–5.32]), high blood sugar (3.43 [2.00–5.89]), cardiovascular disease (3.13 [2.01–4.87]), anxiety (2.87 [1.85–4.44]), arthritis (2.80 [1.83–4.30]), diabetes (2.46 [1.57–3.83]), respiratory problems (2.45 [1.59–3.79]), stomach problems (2.44 [1.57–3.81]), eye disease (2.42 [1.44–4.06]), gallbladder disease (2.34 [1.35–4.05]), liver disease (2.26 [1.38–3.70]), heartburn (2.25 [1.55–3.26]), hyperlipidemia (2.10 [1.44–3.06]), and thyroid conditions (2.04 [1.30–3.21]).

Conclusions

SRH may reflect MDCD burden and serve as a valid screener to efficiently identify Latino individuals in high need of clinical services. This is relevant in Puerto Rico, where chronic disease rates remain high amid limited, disparate access to health care.
The Use of Navigators to Increase Patient Portal Enrollment among Patients in a Federally Qualified Health Care System
Authors: Matthews Alicia K. , Steffen Alana D. , Burke Larisa A. , Donenberg Geri , Duangchan Cherdsak , Akufo Jennifer , Opuada Hope , Oyaluade Damilola , Vilona Brittany Harris , Diaz Hilda , Dodd Darcy
Published: April 2024

Purpose

To describe the training, preliminary results, and lessons learned from using patient navigators to increase the enrollment of low-income patients in a health system–supported and electronic health record–linked patient portal.

Methods

Patient navigators (n=4) were trained to assist patients in a federally qualified health center to enroll in and use patient portals. Patient navigators were stationed at 3 clinic locations. Data from the electronic health record system (Epic) were used to compare MyChart patient portal activation rates and use among patients for the 8 months before and after patient navigation services were offered.

Results

Navigators offered 83% of eligible patients with activation assistance. Sixty-four percent of the patients (n=1062) offered MyChart enrollment assistance accepted help. Seventy-four percent of assisted patients with no prior MyChart enrollment activated their accounts during that clinic visit. The primary reason for declining MyChart assistance was a lack of access to or comfort with technology. Patient portal activation increased during the 8 months when navigators were at the clinics (51%) compared to the previous 8 months (44%). Most new users viewed lab results and read a message [χ2(1)=49.3, p<.001], with significant increases evident for African Americans [44% before, 49% during; χ2(1)=40.4, p<.001] and Latinx patients [52% before, 60% during; χ2(1)=6.15, p=.013].

Conclusion

Study results suggest that using patient navigators is feasible and beneficial for increasing patient enrollment in the Federally Qualified Health Centers context. However, patient-, clinic-, and system-level factors were identified as barriers and should be addressed in future research studies.
Impurity composition of beryl from spodumene pegmatites of Pashki deposit (Nuristan province, Afghanistan)
Authors: Skublov Sergey , Hamdard N. , Ivanov M. , Gavrilchik A. , Stativko V.
Published: April 2024

The SIMS method (secondary ions mass-spectrometry) determined the impurity composition of a beryl crystals (aquamarine) from the pegmatites of the Pashki lithium deposit (Nuristan province, Afghanistan). 12 local determinations of the content of 20 chemical elements (including halogens and water) were performed. In comparison with aquamarine from rare metals, including spodumene pegmatites from other regions of the world, the studied beryl is significantly enriched with large ion lithophile elements: Li (about 1100 ppm), Na (4500 ppm) and K (300 ppm). High concentrations of alkaline elements in the beryl of lithium pegmatites are considered as a genetic sign of the high potential of alkalis created during the crystallization of spodumene associated with beryl and other lithium minerals. This well-known genetically determined feature of beryl, characteristic of productive lithium pegmatites, therefore is promising in the development of search and evaluation criteria for lithium pegmatites of Nuristan and other pegmatite provinces.
Dijital Çağın Potansiyel Çalışanlarının Yapay Zekâ Kaygılarının Belirlenmesi
Authors: ULUKAPI YILMAZ Hande , YILMAZ Abdullah
Published: April 2024

Yapay zekâ bireylerin hayatını kolaylaştırmanın yanında birtakım endişeleri de beraberinde getirmektedir. Bu endişeler literatürde yapay zekâ kaygısı olarak yer almaktadır. Dijital teknolojilerin, mevcut çalışanlara rakip olarak, onların işleri ve mesleklerini tehdit etmekle birlikte, potansiyel çalışanların da istihdam olanakları açısından ciddi bir tehlike yaratabileceği tartışılmaktadır. Bu doğrultuda çalışmada, dijital çağın potansiyel çalışanları olarak görülen gençlerin yapay zekâ kaygılarının belirlenmesi ve bu kaygının demografik özelliklere göre farklılık gösterip göstermediğinin ortaya konulması amaçlanmıştır. Araştırma kapsamında veriler anket tekniği kullanılarak kolayda örnekleme yöntemiyle 318 üniversite öğrencisinden toplanmış, bağımsız örneklem t-testi ve tek yönlü ANOVA testi ile analiz edilmiştir. Analiz sonuçlarına göre üniversite öğrencilerinin yapay zekâ kaygılarının orta seviyede olduğu bulgusu elde edilmiştir. Bunun yanında öğrencilerin sınıfları, akademik başarıları, iş tecrübeleri ve dijital teknolojilere sahip olma durumlarına göre yapay zekâ kaygılarının istatistiksel bakımdan anlamlı farklılıklar gösterdiği tespit edilmiştir. Elde edilen bulguların henüz gelişmekte olan literatüre katkı sağlayacağı ve gelecek çalışmalarda araştırmacılara tartışma imkânı sunacağı düşünülmektedir.
Platelet Biorheology and Mechanobiology in Thrombosis and Hemostasis: Perspectives from Multiscale Computation
Authors: Tuna Rukiye , Yi Wenjuan , Crespo Cruz Esmeralda , Romero JP , Ren Yi , Guan Jingjiao , Li Yan , Deng Yuefan , Bluestein Danny , Liu Z. Leonardo , Sheriff Jawaad
Published: April 2024

Thrombosis is the pathological clot formation under abnormal hemodynamic conditions, which can result in vascular obstruction, causing ischemic strokes and myocardial infarction. Thrombus growth under moderate to low shear (<1000 s-1) relies on platelet activation and coagulation. Thrombosis at elevated high shear rates (>10,000 s-1) is predominantly driven by unactivated platelet binding and aggregating mediated by von Willebrand factor (VWF), while platelet activation and coagulation are secondary in supporting and reinforcing the thrombus. Given the molecular and cellular level information it can access, multiscale computational modelling informed by biology can provide new pathphysiological mechanisms that are otherwise not accessible experimentally, holding promise for novel first-principle-based therapeutics. In this review, we summarize the key aspects of platelet biorheology and mechanobiology, focusing on the molecular and cellular scale events and how they build up to thrombosis through platelet adhesion and aggregation in the presence or absence of platelet activation. In particular, we highlight recent advancements in multiscale modeling of platelet biorheology and mechanobiology and how they can lead to better prediction and quantification of thrombus formation, exemplifying the exciting paradigm of digital medicine.