bluuebunny/crossref_metadata_2025 huggingface dataset:
The association of inflammatory biomarkers with clinical outcomes in diabetic retinopathy participants: data from NHANES 2009–2018
Authors: Si Yueqiao , Chen Qingwei , Xiong XiaoJing , Zheng Minming
Published: July 2024

Objective

The aim of this study was to assess the association of neutrophil lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR), and system inflammation response index (SIRI) with the all-cause mortality and diabetes-cardiovascular mortality in participants with diabetic retinopathy (DR).

Methods

A total of 572 participants with DR from NHANES were included, and divided into survival group (n = 440) and all-cause death group (n = 132). NLR = neutrophil count/lymphocyte count, MLR = monocyte count/lymphocyte count, SIRI = (neutrophil count × monocyte count)/lymphocyte count. We utilized the NHANES Public-Use Linked Mortality File through April 26, 2022, to determine mortality status. Diabetes-cardiovascular death was defined as death resulting from heart disease, cerebrovascular disease, or diabetes mellitus. The Spearson Correlation Analysis, Kaplan-Meier curves, Cox proportional hazards regression models, Restricted cubic spline plots and Decision Curve Analysis were used.

Results

The all-cause mortality and diabetes-cardiovascular mortality were significantly higher in NLR ≥ 1.516, MLR ≥ 0.309, SIRI ≥ 0.756, and NLR + MLR + SIRI subgroups than NLR < 1.516, MLR < 0.309, SIRI < 0.756 subgroups, and other participants except NLR + MLR + SIRI (all P < 0.05). The HR of NLR, MLR, SIRI, NLR + MLR + SIRI for all-cause mortality were 1.979(1.13–3.468), 1.850(1.279–2.676), 1.821(1.096–3.025), 1.871(1.296–2.703), respectively. The hazard ratio of NLR, MLR, SIRI, NLR + MLR + SIRI for diabetes-cardiovascular mortality were 2.602(1.028–6.591), 2.673(1.483–4.818), 2.001(0.898–4.459), 2.554(1.426–4.575), respectively. In the restricted cubic spline plots, the relationship between NLR, MLR, SIRI and HR of all-cause mortality and diabetes-cardiovascular mortality was overall as “J” shaped. In both age < 60 and age > 60 years participants, the all-cause mortality and diabetes-cardiovascular mortality were significantly higher in NLR ≥ 1.516, MLR ≥ 0.309, SIRI ≥ 0.756, and NLR + MLR + SIRI subgroups than NLR < 1.516, MLR < 0.309, SIRI < 0.756 subgroups, and other participants except NLR + MLR + SIRI (all P < 0.05).

Conclusion

NLR, MLR, and SIRI may be three independent prognostic predictors for all-cause mortality and diabetes-cardiovascular mortality among individuals with DR. In practical clinical applications, combining NLR, MLR, and SIRI may enhance the prediction of all-cause mortality and diabetes-cardiovascular mortality in DR.
Effect of capsular polysaccharide phase variation on biofilm formation, motility and gene expression in Vibrio vulnificus
Authors: Zhang Tingting , Ji Shenjie , Zhang Miaomiao , Wu Fei , Li Xue , Luo Xi , Huang Qinglian , Li Min , Zhang Yiquan , Lu Renfei
Published: July 2024

Vibrio vulnificus, a significant marine pathogen, undergoes opaque (Op)-translucent (Tr) colony switching based on whether capsular polysaccharide (CPS) is produced. CPS phase variation is sometime accompanied by genetic variation or down-regulation of particular genes, such as wzb. In addition, CPS prevents biofilm formation and is important to the virulence of V. vulnificus. However, the extent to which there is a difference in gene expression between Tr and Op colonies and the impact of CPS phase variation on other behaviors of V. vulnificus remain unknown. In this work, the data have shown that CPS phase variation of V. vulnificus is affected by incubation time. Tr and Op strains exhibited similar growth rates. However, Tr strains had enhanced biofilm formation capacities but reduced swimming motility compared to Op strains. The RNA-seq assay revealed 488 differentially expressed genes, with 214 downregulated and 274 upregulated genes, between Tr and Op colonies. Genes associated with Tad pili and CPS were downregulated, whereas those involved in flagellum were upregulated, in Tr colonies compared with Op colonies. In addition, 9 putative c-di-GMP metabolism-associated genes and 28 genes encoding putative regulators were significantly differentially expressed, suggesting that CPS phase variation is probably strictly regulated in V. vulnificus. Moreover, 8 genes encoding putative porins were also differentially expressed between the two phenotypic colonies, indicating that bacterial outer membrane was remodeled during CPS phase variation. In brief, this work highlighted the gene expression profiles associated with CPS phase variation, but more studies should be performed to disclose the intrinsic mechanisms in the future.
Insulin promotes the bone formation capability of human dental pulp stem cells through attenuating the IIS/PI3K/AKT/mTOR pathway axis
Authors: E Lingling , Shan Yanbo , Luo Yuxi , feng Lin , Dai Yawen , Gao Mingzhu , Lv Yan , Zhang Chaoran , Liu Hongchen , Wen Ning , Zhang Rong
Published: July 2024

Background

Insulin has been known to regulate bone metabolism, yet its specific molecular mechanisms during the proliferation and osteogenic differentiation of dental pulp stem cells (DPSCs) remain poorly understood. This study aimed to explore the effects of insulin on the bone formation capability of human DPSCs and to elucidate the underlying mechanisms.

Methods

Cell proliferation was assessed using a CCK-8 assay. Cell phenotype was analyzed by flow cytometry. Colony-forming unit-fibroblast ability and multilineage differentiation potential were evaluated using Toluidine blue, Oil red O, Alizarin red, and Alcian blue staining. Gene and protein expressions were quantified by real-time quantitative polymerase chain reaction and Western blotting, respectively. Bone metabolism and biochemical markers were analyzed using electrochemical luminescence and chemical colorimetry. Cell adhesion and growth on nano-hydroxyapatite/collagen (nHAC) were observed with a scanning electron microscope. Bone regeneration was assessed using micro-CT, fluorescent labeling, immunohistochemical and hematoxylin and eosin staining.

Results

Insulin enhanced the proliferation of human DPSCs as well as promoted mineralized matrix formation in a concentration-dependent manner. 10− 6 M insulin significantly up-regulated osteogenic differentiation-related genes and proteins markedly increased the secretion of bone metabolism and biochemical markers, and obviously stimulated mineralized matrix formation. However, it also significantly inhibited the expression of genes and proteins of receptors and receptor substrates associated with insulin/insulin-like growth factor-1 signaling (IIS) pathway, obviously reduced the expression of the phosphorylated PI3K and the ratios of the phosphorylated PI3K/total PI3K, and notably increased the expression of the total PI3K, phosphorylated AKT, total AKT and mTOR. The inhibitor LY294002 attenuated the responsiveness of 10− 6 M insulin to IIS/PI3K/AKT/mTOR pathway axis, suppressing the promoting effect of insulin on cell proliferation, osteogenic differentiation and bone formation. Implantation of 10− 6 M insulin treated DPSCs into the backs of severe combined immunodeficient mice and the rabbit jawbone defects resulted in enhanced bone formation.

Conclusions

Insulin induces insulin resistance in human DPSCs and effectively promotes their proliferation, osteogenic differentiation and bone formation capability through gradually inducing the down-regulation of IIS/PI3K/AKT/mTOR pathway axis under insulin resistant states.
Leveraging oncovirus-derived antigen against the viral malignancies in adoptive cell therapies
Authors: Zhang Wei , Zeng Miao , Li Yisheng , Yu Li
Published: July 2024

Adoptive cell therapies (ACTs) have revolutionized cancer immunotherapy, prompting exploration into their application against oncoviruses. Oncoviruses such as human papillomavirus (HPV), hepatitis B virus (HBV), hepatitis C virus (HCV), and Epstein-Barr virus (EBV) contribute significantly (12-25%) to human malignancies through direct or indirect oncogenic mechanisms. These viruses persistently or latently infect cells, disrupt cellular homeostasis and pathways, challenging current antiviral treatment paradigms. Moreover, viral infections pose additional risks in the setting of long-term cancer therapy and lead to morbidity and mortality. Virally encoded oncoproteins, which are tumor-restricted, immunologically foreign, and even uniformly expressed, represent promising targets for patient-tailored ACTs. This review elucidates the rationale for leveraging viral antigen-specific ACTs in combating viral-associated malignancies. On this basis, ongoing preclinical studies consolidate our understanding of harnessing ACTs against viral malignancies, underscoring their potential to eradicate viruses implicated in cancer progression. Furthermore, we scrutinize the current landscape of clinical trials focusing on virus-specific ACTs and discuss their implications for therapeutic advancement.
Development of an opto-electrochemical sensor for the detection of malathion using manganese metal–organic framework (Mn-MOF)
Authors: Sankhla Lakshya , Kushwaha Himmat Singh
Published: July 2024

This paper presents a new method for detecting malathion pesticides using a modified screen-printed electrode (SPE) with a fluorescence quenching technique. The manganese-based MOF was synthesized using the solvothermal method. The synthesized MOFs were characterized by transmission electron microscopy (TEM), x-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and Raman spectroscopy. The material’s electrocatalytic properties were assessed via electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). Within the concentration range of 0.89 µM to 5.95 µM, the material’s response to malathion was analyzed with square wave voltammetry (SWV), giving rise to a detection limit of 39.097 nM. Fluorescence quenching studies have been carried out between 0.039 and 0.56 µM, with a lower detection limit of 62.03 nM. A sensor with good anti-interference properties was tested for selectivity and practicability in detecting malathion in real samples, proving its potential use in this area.
Pancreaticoduodenectomy after postoperative gastric tube reconstruction for esophageal cancer with median arcuate ligament syndrome: a case report
Authors: Izumi Hideki , Yoshii Hisamichi , Fujino Rika , Takeo Shigeya , Kojima Yukiko , Kaneko Junichi , Mukai Masaya , Chino Osamu , Makuuchi Hiroyasu
Published: July 2024

Background

Pancreaticoduodenectomy (PD) is considered a challenging surgery for resecting the gastroduodenal artery (GDA), right gastric artery (RGA), and lymph node tumors. In cases of pancreatic head cancer surgery, vascular anastomosis or right gastroepiploic artery (RGEA)/GDA preservation is necessary after postoperative gastric tube reconstruction for esophageal cancer. Therefore, we report for the first time an extremely rare case of PD in a patient with pancreatic head cancer and median arcuate ligament syndrome (MALS) after gastric tube reconstruction following esophageal cancer surgery, in which the entire pancreatic head arcade was preserved.

Case presentation

The patient was a 76-year-old man who had undergone esophageal cancer surgery after sternal gastric tube reconstruction 7 years ago. He was referred to our hospital because of the suspicion of intraductal papillary mucinous carcinoma (IPMC) owing to an enlarged cystic lesion and a substantial component in the uncinate process of the pancreas. Preoperative three-dimensional computed (3D-CT) tomography angiography showed celiac axis stenosis and pancreatic head arcade dilation. The diagnosis was IPMC without evidence of invasion; therefore, gastric tube blood flow was maintained by preserving the GDA and RGEA. Due to MALS, the GDA blood flow was supplied through the pancreatic head arcade, necessitating its preservation. The GDA-RGEA, right gastroepiploic vein, and anterior superior pancreaticoduodenal artery were taped over the entire pancreatic head for preservation. The inferior pancreaticoduodenal artery (IPDA) was also taped on the dorsal pancreas and the posterior or anterior IPDA, which further bifurcates were taped to preserve them. Subsequently, PD was performed.

Conclusion

We report a case of PD after gastric tube reconstruction for esophageal cancer with MALS, in which the pancreatic head arcade vessels were successfully preserved using 3D-CT to confirm the operation of the vessels.
Influence of enhanced self-efficacy on English performance through English medium instruction: a mixed methods research
Authors: Huang Wen-Chi
Published: July 2024

The adoption of English-Medium Instruction (EMI) has gained global traction, spurred on by higher education internationalization trends. Despite the widespread usage of EMI, its influence on students’ language development remains relatively unexplored. This study investigated the impact of EMI instruction on the self-efficacy and English performance of Taiwanese English as a Foreign Language (EFL) undergraduates. The research aimed to discern whether EMI courses improve EFL undergraduates’ self-efficacy and how this self-efficacy can predict English performance. 272 Taiwanese EFL undergraduates were recruited for the study, and all of them joined the EMI courses for at least one semester. Data collection instruments included a revised questionnaire and TOEIC test, and a mixed approach was applied for data analyses. Quantitative analyses of repeated measure of ANOVA revealed a significant enhancement in the students’ self-efficacy across all four English skills (listening, speaking, reading, and writing) following EMI instruction. Moreover, the regression analysis established a moderate to strong positive relationship between English self-efficacy and English performance. The qualitative analysis of structured interview specifically elaborated on what participants’ attitudes were toward the implementation of EMI. These findings underscore the positive influence of EMI instruction on EFL undergraduates’ English self-efficacy and performance, substantiating the role of self-efficacy as a significant predictor of performance. These insights offer valuable implications for curriculum design, learner motivation, and academic success in EFL contexts.
Theory of Mind and physical bullying in preschool children: the role of peer rejection and gender differences
Authors: Zhou Yanfang , Deng Xiaojie , Wang Sihui , Shi Leishan
Published: July 2024

Background

Preschool represents the budding and initial stage of bullying behavior, where perpetration of physical bullying predominates as the primary form of bullying. An in-depth understanding of the factors linked to preschool physical bullying behavior is crucial for enabling early prevention and intervention strategies.

Objective

The purpose of this study was to examine the relationship between Theory of Mind and physical bullying behavior in 4–6 years old children in kindergarten and the mediating role of peer rejection and gender in this relationship.

Methods

Data on perpetration of physical bullying and peer rejection were obtained from 310 preschool children (age range = 52–79 months, M = 66.85, SD = 7.04) by the peer nomination method, and their Theory of Mind was measured by the Theory of Mind Development Scale.

Results

The results showed that Theory of Mind negatively predicted perpetration of physical bullying in preschool children and that Theory of Mind was related to perpetration of physical bullying in preschool children only through peer rejection. Boys were also found to have a stronger association between peer rejection and perpetration of physical bullying in preschool children than girls.

Conclusion

Peer rejection may play a mediating role between Theory of Mind and perpetration of physical bullying in preschool children. In addition, the relationship between peer rejection and perpetration of physical bullying appears to be stronger for boys than for girls. This contributes to our understanding of the relationship between Theory of Mind and perpetration of physical bullying in preschool children and has implications for how bullying prevention and intervention can be tailored to the gender of young children.
Overstory and fuel traits drive moisture dynamics of mesophytic and pyrophytic leaf litter and 10-h woody debris fuels in a mixed longleaf pine-hardwood woodland
Authors: Gonçalves Lazzaro Luiza , Alexander Heather D. , Cannon Jeffery B. , Aspinwall Michael J.
Published: July 2024

Background

Following decades of fire exclusion, many open pine and oak forests across the central and eastern US are shifting to closed-canopy forests that are increasingly dominated by shade-tolerant, fire-sensitive species (i.e., mesophytes). As mesophytes encroach into historically pyrophytic landscapes, changes in crown traits and understory microclimate may interact with fine fuel traits to influence fuel moisture retention, and ultimately, fire behavior. To better understand potential interactions among overstory trees and underlying fine fuels that occur during mesophyte encroachment, we measured in situ drying rates of leaf litter and 10-h woody debris of three functional groups (pyrophytic pine, pyrophytic oak, and mesophytic oak) in gaps and beneath overstory trees of each functional group within a longleaf pine-mixed oak woodland along with crown (area, volume, cover), leaf litter (curling, thickness, specific leaf area, volume), and woody debris (density) traits of each functional group and understory microclimate (vapor pressure deficit (VPD)).

Results

We found that leaf litter from pyrophytic and mesophytic oaks had higher initial moisture content than pyrophytic pines, but pyrophytic pine and pyrophytic oak leaf litter dried 1.5 times faster than that of mesophytic oaks, likely due to their greater leaf curl, thickness, and volume. Initial moisture content of mesophytic oak woody fuels was lower than that of pyrophytic pine and pyrophytic oak, potentially because of higher wood density, but there were no differences in fuel drying rates. Regardless of fuel functional type, leaf litter and woody fuels dried 1.5 times faster in gaps and underneath pyrophytic pine compared to mesophytic oaks, likely due to the more open conditions in these areas. Notably overstory functional group and time of the day interacted to influence VPD, with VPD increasing throughout the day for all groups, but more so for gaps and beneath pyrophytic pines than either oak functional group.

Conclusions

Thus, fuel and crown traits differentially impacted understory microclimate and leaf litter and 10-h woody debris drying rates, leading to slower drying of fuels of encroaching mesophytes compared to pyrophytic pines and oaks, which could lead to reduced forest flammability, and consequently, the continued encroachment of mesophytic species into fire-dependent pine and oak forests.
Role of mechanical thrombectomy among large vessel stroke patients during the coronavirus disease (COVID-19) pandemic
Authors: Sammak Dena Abd El Aziz El , Nada Mohamad Gamal , Lakouz Karim Khaled , Libda Yasmin Ibrahim
Published: July 2024

Purpose

The aim of our study is to provide insights derived from experience at multiple centers regarding the outcomes of mechanical thrombectomy (MT) for large vessel occlusion (LVO) in COVID-19 patients and compare them with those in non-COVID-19 patients during the coronavirus disease (COVID-19) pandemic.

Results

COVID‐19 positive patients were younger than COVID‐19 negative patients (62.1 ± 2.69 versus 69.5 ± 2.2, P < 0.001). There was a significant difference between COVID-19 and non-COVID-19 groups in the median D-dimer levels (6 vs. 4.5; P < 0.001), median ESR levels (63 vs. 38; P < 0.001) and median CRP levels (110 vs. 48.5; P < 0.001), respectively. Median time from stroke symptoms onset to hospital admission was significantly higher among COVID-19 positive patients (366 vs. 155 min; P < 0.001). COVID‐19 positive patients with LVO presented with a higher median NIH Stroke Scale score at presentation (16 versus 8, P < 0.001) and lower median Alberta Stroke Program Early CT Score (ASPECTS) on admission (6 versus 8, P < 0.001). Patients with COVID-19 had significantly higher percentages of poor functional outcomes as scored using the mRS grades 3–5 in comparison to non-COVID-19 patients (69.2% vs. 13.6%; P = 0.002), but there was no significant difference between both groups in complications such as early cerebral re-occlusion, intracerebral hemorrhage, or in-hospital mortality (P > 0.05).

Conclusion

Mechanical thrombectomy has effectively managed patients with LVO stroke. LVO stroke in COVID-19 patients occur at a young age, and have multi-territory vascular involvement. Poor functional outcomes post thrombectomy in COVID-19 patients, irrespective of timely, successful angiographic recanalization.
A Kinky Consistency: Experimental Evidence of Behavior under Linear and Nonlinear Budget Constraints
Authors: Huet-Vaughn Emiliano , McClure Ethan M. L. , Serrato Juan Carlos Suárez
Published: July 2024

Individuals face nonlinear incentives in myriad situations. We test a fundamental assumption in such settings: that individuals display stable preferences when facing linear and nonlinear incentives. We use a laboratory experiment to characterize how revealed preferences are affected by changes in the budget set environment. Choices under kinked budgets exhibit the same very high levels of internally consistent behavior as they do under linear budgets. However, for about half the subjects, choices across settings are inconsistent with the maximization of a stable preference. Subjects displaying arbitrary consistency exhibit large and significant changes in utility parameters, risk premiums, and price elasticities across settings. (JEL C91, D12, D81, D91)
Ερημοποίηση και διεθνής περιβαλλοντική διακυβέρνηση
Authors: Πλιάτσικας Χρήστος
Published: July 2024

Η ερημοποίηση είναι ένα σύνθετο φαινόμενο καθώς παρότι αφορά το περιβάλλον, οι ευρύτερες επιπτώσεις του το καθιστούν αναπτυξιακό πρόβλημα. Για το λόγο αυτό, η καταπολέμησή του συνιστά μία πρόκληση για την ανθρωπότητα και ιδιαίτερα για τις αναπτυσσόμενες χώρες που το υφίστανται σε μεγάλο βαθμό. Η υιοθέτηση του θεσμικού πλαισίου καταπολέμησης, έδωσε τη δυνατότητα της καταγραφής των προβλημάτων και της χάραξης εθνικών στρατηγικών αντιμετώπισης, τόσο με την οικονομοτεχνική στήριξη του ανεπτυγμένου Βορρά προς τις χώρες του αναπτυσσόμενου Νότου που το βιώνουν εντονότερα, όσο και με την στήριξη των εθνικών προσπαθειών των αναπτυσσόμενων χωρών. Οι προσπάθειές τους ενισχύονται από τη μεταξύ τους συνεργασία σε επίπεδο υποπεριφέρειας και περιφέρειας. Έτσι, δημιουργούνται προοπτικές μιας αυτοδύναμης και βιώσιμης αναπτυξιακής πορείας με οικοδόμηση αλληλεγγύης και συνδυασμένης αξιοποίησης της παραδοσιακής και επιστημονικής γνώσης υπό το πρίσμα της bottom-up προσέγγισης με την ενεργή συμμετοχή των τοπικών πληθυσμών. Σκοπός της παρούσας διατριβής είναι η ανάδειξη των διεθνών προσπαθειών καταπολέμησης της ερημοποίησης με έμφαση στον αναπτυσσόμενο Νότο και στην ανάπτυξη περιφερειακών πρωτοβουλιών Νότου-Νότου καθώς οι επιπτώσεις της στις χώρες αυτές είναι εντονότερες λόγω των οικονομικών, τεχνικών και ευρύτερα αναπτυξιακών αδυναμιών που αντιμετωπίζουν. Για το λόγο αυτό, επιχειρήθηκε η ολιστική προσέγιση της ερημοποίησης ως φυσικό φαινόμενο με τις προεκτάσεις της σε όλο το φάσμα της βιώσιμης ανάπτυξης, καθώς επίσης και η εξέταση της λειτουργίας του θεσμικού καθεστώτος, ώστε να διαπιστωθεί η εφαρμοσιμότητα των περιφερειακών παρεμβάσεων των αναπτυσσόμενων χωρών στη στήριξη των τοπικών δράσεων, του μέσου αντιμετώπισης της ερημοποίησης λόγω της προσιτής διαχείρισής της σε αυτό το επίπεδο, με προοπτική να αποτελέσουν θετικά ή αρνητικά παραδείγματα για αντίστοιχες πρωτοβουλίες.
Η επίδραση της προπονητικής επιβάρυνσης κατά τη διάρκεια της προαγωνιστικής περιόδου στο εργομετρικό και βιοχημικό προφίλ αθλητών και αθλητριών καλαθοσφαίρισης υψηλού επιπέδου
Authors: Μέξης Δημήτριος
Published: July 2024

Η μελέτη αυτή εξέτασε την επίδραση 3 πρωτοκόλλων φυσικής κατάστασης προαγωνιστικής περιόδου, στις φυσικές ικανότητες των αθλητών και αθλητριών καλαθοσφαίρισης όπως αυτές εκφράζονται μέσα απ’ την εργομετρική αξιολόγηση, αλλά και στους βιοχημικούς δείκτες μέσω ανάλυσης δειγμάτων σίελου και αίματος. Επίσης, πραγματοποιήθηκε σύγκριση και αναζήτηση συσχετίσεων ανάμεσα στις φυσιολογικές και βιοχημικές μεταβολές που προκλήθηκαν απ’ το κάθε πρωτόκολλο, αρχικά ανάμεσα σε άντρες και γυναίκες και στη συνέχεια ανάμεσα στις γυναίκες αθλήτριες της μέλετης. Τέλος, στο πλαίσιο των βιοχημικών μετρήσεων και επειδή η λήψη και η μέτρηση βιοχημικών δεικτών στο αίμα είναι επίπονη, χρονοβόρα διαδικασία που απαιτεί εξειδικευμένο προσωπικό κατά τη διάρκεια της προετοιμασίας, ήταν ιδιαίτερα σημαντικό μέσω της παρούσας μελέτης να αναδειχτούν δείκτες και σε πιο εύκολα προσβάσιμα βιολογικά δείγματα όπως είναι ο σίελος. Το δείγμα αποτελούνταν από 38 αθλητές και αθλήτριες καλαθοσφαίρισης υψηλού επιπέδου (28 γυναίκες – 10 άνδρες), οι οποίοι αγωνίζονταν σε 4 διαφορετικές ομάδες (3 ομάδες γυναικών – 1 ομάδα ανδρών). Οι εργομετρικοί δείκτες που μετρήθηκαν είναι: αερόβια ικανότητα, αναερόβια ικανότητα, αλτικότητα, ταχύτητα, επιτάχυνση, εκρηκτικότητα και μέγιστη δύναμη κάτω άκρων. Οι βιοχημικές μετρήσεις αποτελούνταν από: βασικές αιματολογικές εξετάσεις, δείκτες μεταβολικού προφίλ, δείκτες ασκησιογενούς μυϊκής βλάβης και φλεγμονής, δείκτες οξειδωτικού στρες, δείκτες ορμονολογικού προφίλ, δείκτες ενυδάτωσης. Τα πρωτόκολλα φυσικής κατάστασης που χρησιμοποιήθηκαν έδειξαν ότι είναι ικανά μετά από 6 εβδομάδες προαγωνιστικής περιόδου να βελτιώσουν την απόδοση των αθλητών και αθλητριών καλαθοσφαίρισης υψηλού επιπέδου, ενώ το μέτριο πρωτόκολλο φάνηκε να παρουσιάζει καλύτερη ισορροπία βελτίωσης του εργομετρικού και βιοχημικού προφίλ σε σύγκριση με τα υπόλοιπα 2. Βασικός στόχος της μελέτης ήταν όλα τα παραπάνω ευρήματα να προσδώσουν περισσότερες γνώσεις και εφόδια στους προπονητές και στους γυμναστές καλαθοσφαίρισης, να βελτιστοποιήσουν την προπονητική διαδικασία κατά την προαγωνιστική περίοδο, και κατ’ επέκταση να μεγιστοποιήσουν την απόδοση των αθλητών και αθλητριών μέσω της ελάττωσης της συστηματικής κόπωσης.
Technanukowe jest polityczne. Próba ANT-owskiego pomyślenia ludzkiej sprawczości w świecie nie(do)rzeczy.
Authors: Wąż Rafał
Published: July 2024

Celem tekstu jest próba ujęcia sprawczości człowieka osadzonego w świecie, w którym coraz większą rolę odgrywają technologie cyfrowe – przez Byung-Chul Hana nazywane nie(do)rzeczami. Sprawczość rozumiem jako zdolność do uprawiania polityki w Latourowskim sensie tego słowa. Dla francuskiego filozofa, polityka jest to: „stopniowa kompozycja wspólnego świata”. To również ANT (Actor-Network Theory) – koncepcja rozwijana przez Bruno Latoura – będzie dostarczycielką pojęć służących realizacji celu artykułu. Inspirację dla pierwszej części tytułu niniejszego tekstu tj. Technonaukowe jest polityczne stanowi esej The personal is political. Uważam bowiem, że wytwory współczesnej technonauki, czyli wspomniane nie(do)rzeczy w pewnych obszarach mają ogromną zdolność kształtowania naszej rzeczywistości. Podobnie jak zdaniem Hanisch sfera publiczna ma ogromną zdolność do kształtowania sfery uważanej za prywatną czy intymną.
Czy Putin „mówi Duginem”? Porównanie myśli politycznej Aleksandra Dugina z myślą Władimira Putina w świetle radykalizacji światopoglądu prezydenta Federacji Rosyjskiej
Authors: Kwiatkowski Sebastian
Published: July 2024

Celem niniejszego artykułu jest określenie poziomu korelacji pomiędzy myślą polityczną Aleksandra Dugina oraz Władimira Putina na przestrzeni ich działalności. Charakteryzując myśl polityczną Aleksandra Dugina oraz Władimira Putina, odnosząc się do zachodzącej ewolucji poglądów u Prezydenta Federacji Rosyjskiej, jesteśmy w stanie określić w jakim stopniu myśl polityczna badanych podmiotów jest ze sobą zbieżna. Dokonując analizy treści publikacji Aleksandra Dugina oraz treści wystąpień Władimira Putina wskazujemy, że zachodzi zbieżność w fundamentalnych celach obu badanych obiektów, jakim jest odrestaurowanie potęgi Rosji. Wskazujemy jednak, że myśl polityczna Dugina jest zdecydowanie wysoce rozbudowana, przez co jej implementacja wydaje się niemożliwa. Zarazem plany imperialne Dugina obejmują szerszy zakres geograficzny, wychodzący poza obszar poradziecki, a nawet były Blok Wschodni. Różnica także polega w interpretacji inwazji Rosji na Ukrainę z roku 2022. Putin w narracji wskazuje, że to było uderzenie wyprzedzające, a celem politycznym było zmuszenie Zachodu do przyjęcia rosyjskich roszczeń. Dugin z kolei interpretuje inwazję jako emanację Radykalnego Podmiotu - bogonoścy.
Anarchizm a polityki prefiguracyjne
Authors: Drabiński Maciej
Published: July 2024

Niniejszy artykuł poszukuje źródeł polityk prefiguracyjnych w doktrynie klasycznego anarchizmu. Teza artykułu zakłada, iż aksjologiczne, epistemologiczne, a także ontologiczne założenia anarchizmu stanowiły przyczynę rozwoju oraz faworyzowania w doktrynie i w praktyce ruchu anarchistycznego polityk prefiguracyjnych. W konsekwencji klasyczny anarchizm stanowił jedno z istotniejszych źródeł wspomnianej strategii. Tym samym artykuł zmierza do wypełnienia luki badawczej jaka wykształciła się w polskiej politologii zarówno wokół anarchizmu, jak i polityk prefiguracyjnych. W artykule stosowana jest jakościowa analiza treści oraz metoda porównawcza.
Polski i litewski model samorządu terytorialnego w ujęciu historycznym - analiza porównawcza ze szczególnym uwzględnieniem stosowania budżetu obywatelskiego
Authors: Przestrzelska Katarzyna
Published: July 2024

Zarówno Polska, jak i Litwa to państwa, które na przestrzeni lat przechodziły dynamiczne zmiany ustrojowe. Były one spowodowane niestabilną sytuacją polityczną i wpływami sowieckimi. W artykule przeprowadzono analizę porównawczą funkcjonowania samorządu terytorialnego w Polsce i na Litwie, mającą na celu wskazanie podstawowych różnic i podobieństw w tym obszarze z uwzględnieniem aspektów historycznych. Analiza porównawcza została oparta na przykładzie funkcjonowania polskiej wiejsko-miejskiej Gminy Wyszków oraz litewskiego Samorządu Rejonu Solecznickiego. Przeprowadzona analiza porównawcza ostatecznie pozwoliła na wskazanie instrumentów konsultacji społecznych stosowanych przez polski samorząd gminny, które mogłyby być wykorzystane przez samorząd rejonu litewskiego.
Comprehensive Management of Child Maltreatment Syndrome: A Case Study and Clinical Implications in An Infant
Authors: Kowalczyk Emilia , Koziej Sylwia , Borkowska Joanna , Bajorek Julia
Published: July 2024

Introduction and purpose
 
The World Health Organization (WHO) defines violence against children as “all forms of physical and emotional maltreatment, sexual abuse, neglect and exploitation that result in actual or potential harm to a child's health, development or dignity.” In Poland, 17,392 cases of violence against children and adolescents were reported in 2015. In the U.S. in 2012, 3.4 million children were reported to facilities for maltreatment. Violence against children leads to serious health problems, both physical and mental, as well as long-term social consequences. Despite its prevalence, many cases remain unreported, with victims, particularly infants, being highly vulnerable.
In the case described, a boy born at 36 weeks gestation was admitted to the hospital with symptoms of apathy. Examination revealed neurological symptoms, multiple intracranial hematomas, skull bone fractures and hearing loss. The ophthalmic consultation and examination revealed the presence of retinal hemorrhages, confirming the diagnosis of child maltreatment syndrome. Prompt medical and legal intervention allowed the child's condition to be stabilized, allowing for proper further development in foster care.
This article presents a clinical case of maltreatment syndrome in an infant, with a discussion of complications and abnormalities in the performed investigations and a discussion of the treatment administered. 
 
Conclusion 
 
Prompt recognition of such cases is vital, considering the potential long-term physical and psychological consequences. Practical implications for medical personnel and the need to cooperate with social and legal institutions to provide adequate care for abused children are discussed. The presented case underscores the need for comprehensive approaches to address child maltreatment, involving medical, legal, and social interventions to safeguard the welfare of affected children.
Impact of Modern Lifestyle on Circadian Rhythms
Authors: Zaucha Radosław , Anczyk Stanisław , Silldorff Julia , Dudek Marcin , Gajkiewicz Magdalena , Zając Małgorzata , Fura Tomasz , Iszczuk Oliwia , Felińska Zuzanna
Published: July 2024

Introduction and purpose: Circadian rhythms are internal processes that regulate the sleep-wake cycle and repeat roughly every 24 hours. These rhythms are driven by a biological clock, primarily located in the suprachiasmatic nucleus (SCN) of the brain. Synchronized with environmental cues such as light and darkness, they play a crucial role in regulating sleep-wake patterns, hormone secretion, metabolism, and other physiological functions. Disruptions in circadian rhythms can have wide-ranging effects on health. This review aims to synthesize the current state of knowledge on how lifestyle factors affect circadian rhythms and explore the subsequent implications for both mental and physical health.
Description of the state of knowledge: Modern lifestyles factors characterized by artificial lighting, shift work, noise pollution, excessive caffeine use, worldwide traveling and irregular eating habits can significantly disrupt natural circadian rhythms. Such disruptions are associated with a spectrum of pathologies, such as sleep dysregulation, mood disorders (e.g., depression and bipolar disorder), metabolic impairments, and suboptimal immune responses.
Summary: This review synthesizes current research findings on the impacts of lifestyle-induced circadian misalignment, highlighting the complex interactions between modern life and circadian biology. Maintaining circadian rhythm integrity is crucial not just for enhancing overall well-being but also as a preventive strategy against a wide range of diseases. Integrating this understanding into health practices is essential for addressing the pervasive impact of circadian disruptions in modern society.
The influence of physical activity, diet, and lifestyle of patients on the course of polycystic ovary syndrome (PCOS) in women
Authors: Różańska-Smuszkiewicz Gabriela , Smuszkiewicz-Różański Paweł , Kmiotek Weronika , Ragan Dagmara , Oronowicz Radosław , Staszczak Paweł , Jaworska Barbara , Długosz Joanna , Bara Maciej , Jama Grzegorz
Published: July 2024

Polycystic ovary syndrome (PCOS) is an endocrine disorder caused by multiple genetic and environmental factors, affecting women of reproductive age but extending across all stages of a woman's life [1]. Major symptoms in many PCOS patients include menstrual cycle irregularities, difficulties in maintaining normal body weight, excessive body hair growth, acne, and fertility problems. The prevalence of PCOS varies depending on the definition used, ranging between 6-20%, making it the most common endocrine disorder among women of reproductive age [2,3]. It accounts for approximately 80% of cases of anovulatory infertility, disrupting various stages of the reproductive axis. Evidence from numerous studies suggests that lifestyle modification should be the first-line therapy for women with PCOS [4]. This paper focuses on research evaluating the treatment of this condition through lifestyle changes, physical activity, and diet. Such therapeutic interventions can significantly improve clinical outcomes and the health profile of PCOS patients by promoting favorable changes in body composition, partially normalizing sex hormone levels, reducing inflammatory parameters, and improving mental health. Therefore, the adoption of comprehensive lifestyle modifications is crucial in the treatment of polycystic ovary syndrome.
Overview of available vitamin and supplement products used to improve immune system function
Authors: Cąkała Marlena , Zajkowska Aleksandra , Kozioł Magdalena , Podgórniak Kamila , Błaszczak Karolina , Skotnicka Joanna , Witkowska Maria
Published: July 2024

Introduction:
Questioning how we can boost our immunity during the infectious season often arises in the general practicioner’s office. Patients report issues with recurring infections, affecting not only children but also adults, particularly those in professionally exposed groups such as teachers. Therefore, is it worthwhile to recommend over-the-counter (OTC) products available in pharmacies to patients, aiming to strengthen their immunity? This article discusses the most commonly used supplements and immune-boosting preparations by patients and physicians, along with scientific evidence regarding their effectiveness.
Material and methods: The basis of the work were medical articles collected in the PubMed database. The research was conducted by analyzing key words such as: vitamin D3, immunity improvement, zinc, bacterial lysates, lactoferrin, fish oil, omega-3 fatty acids, Echinacea purpurea, Spirulina maxima, curcumin, probiotics, ginseng.
Results: In the pharmaceutical market, there are many supplements aimed at boosting the immune system. However, most of them lack sufficient scientific evidence regarding their effectiveness. The studies conducted so far are of low quality and limited in number. Further research is necessary to demonstrate the efficacy and safety of immune-boosting supplements.
De víctimas y excombatientes, una revisión de los esfuerzos de las IES de Neiva-Huila por la inclusión de cara al posconflicto.
Authors: Pinzón Silva Angela , Angarita Calderón Camilo , Armenta Arrieta Natalia
Published: July 2024

Este estudio examina el papel de las Instituciones de Educación Superior (IES) en Neiva, Huila, en la implementación de ambientes inclusivos para víctimas y excombatientes post Acuerdo de Paz de La Habana. El objetivo general es evaluar la contribución de las IES a la construcción de entornos inclusivos en el contexto postconflicto. El problema aborda la necesidad de comprender el impacto de estas instituciones en la reintegración social, buscando responder a la pregunta ¿Cómo las Instituciones de Educación Superior (IES) del municipio de Neiva, Huila han sido parte de los procesos de construcción e implementación de ambientes inclusivos para las víctimas y excombatientes del conflicto armado luego de firmado el Acuerdo de Paz de La Habana? La metodología se basa en un enfoque cualitativo, incluyendo análisis normativo y revisión de acuerdos de inclusión universitaria para comprender la participación de las IES en el proceso de paz.
AVALIAÇÃO COMPARATIVA DA ATIVIDADE ESTROGÊNICA EM ALGUMAS PRAIAS DA ENSEADA DE JURUJUBA NO ANO DE 2012 E NO ANO DE 2016 E POTENCIAIS RISCOS PARA SAÚDE HUMANA E AMBIENTAL
Authors: Nascimento Marilia Teresa Lima , Santos Ana Dalva de Oliveira , Dos Santos Rejany Ferreira , Da Cunha Danieli Lima , De Freitas Alex da Silva , Da Fonseca Estefan Monteiro , Bila Daniele Maia , Baptista Neto José Antônio
Published: July 2024

Ambientes costeiros são muito afetados por diversos poluentes. Substâncias com potenciais estrogênicos causam efeitos adversos mesmo em baixas concentrações da ordem de µg L-1 e ng L-1. Em humanos, entre os riscos associados estão: cânceres, ovários policísticos, redução na quantidade de esperma, resistência bacteriana, entre outros. Em animais, masculinização, feminização, condições de intersex e até extinção da espécie. O objetivo deste estudo é comparar os resultados obtidos na avaliação da atividade estrogênica nos anos de 2012 e 2016 nas praias de São Francisco, Charitas, Jurujuba, Adão e Eva. Na metodologia foram realizados: ensaio in vitro Yeast Estrogen Screen (YES), com levedura de Saccharomyces; toxicidade aguda com a bactéria Vibrio fischeri e os parâmetros físico-químicos. Em 2012 a atividade estrogênica em E2-EQ variou de não detectada (ND) a 3,2 ng L-1 e em 2016 de 72,0 - 77,8 ng L-1. A toxicidade aguda não foi observada e os parâmetros físico-químicos, apresentaram-se dentro dos padrões estabelecidos pela legislação brasileira. O significativo aumento da atividade estrogênica quatro anos após a primeira análise, aponta para graves impactos e potenciais riscos ambientais, tanto para a biota quanto para a saúde dos indivíduos que usufruem destas praias.
ESTIMATIVA DOS BAIRROS DEFICITÁRIOS EM SANEAMENTO BÁSICO NA REGIÃO METROPOLITANA DO RIO DE JANEIRO EM 2020
Authors: Arouca Maria Clara , Canton Cardoso Sandra , Mercedes Strauch Julia Celia
Published: July 2024

A precariedade no acesso ao saneamento básico afeta a saúde, o meio ambiente e a qualidade de vida da população excluída desse direito. Os dados do Censo de 2010 já demonstravam as desigualdades inter e intramunicipais do saneamento na Região Metropolitana do Rio de Janeiro (RMRJ). Contudo, considerando a inexistência de dados recentes do Censo Demográfico, o presente trabalho objetiva identificar para o ano de 2020 os grupos de bairros que necessitam de prioridade no acesso aos serviços de água e esgotamento sanitário na RMRJ. Para isso, a metodologia proposta estima os dados de saneamento para 2020 a partir dos dados de saneamento do Censo de 2010 e do mapeamento dasimétrico que emprega como dado auxiliar o mapa de uso e cobertura da terra e a seguir efetua análise de agrupamento para identificar os grupos de bairros prioritários. Os bairros de prioridade máxima totalizaram 13, nos municípios de Magé, Belford Roxo, Duque de Caxias, Itaboraí, Nova Iguaçu e Rio Bonito. Os resultados evidenciaram as desigualdades entre os bairros e também entre os municípios, além de possibilitar identificar as diferentes necessidades de cada bairro, enquadrando-os em sete grupos distintos, para que seja possível promover políticas públicas adequadas.
EDUCAÇÃO GEOGRÁFICA POR IMAGENS: AS FOTOGRAFIAS COMO POSSIBILIDADES PARA PENSAR RELAÇÕES ESPACIAIS COM CRIANÇAS
Authors: Pauli Marieli Maria
Published: July 2024

As fotografias, cada vez mais presentes em nosso cotidiano, nos mais diversos contextos, pode potencializar as leituras, a construção de conhecimentos, produção de pensamentos e imaginações geográficas sobre os lugares e o mundo que nos cerca. Nesse sentido, tendo em vista a importância das fotografias, bem como, da centralidade do conceito de lugar na educação geográfica, o objetivo deste trabalho é verificar as potencialidades das imagens fotográficas de lugares de vivência, a exemplo de bairros e comunidades, presentes em livros didáticos de Geografia para os anos iniciais do Ensino Fundamental para abordar o conceito de lugar com esses estudantes. Para tanto, analisamos cinco conjuntos de fotografias de bairros e comunidades presentes nos livros didáticos de Geografia do 2º e 3º ano de uma das coleções aprovadas no PNLD de 2019, identificando limites e possibilidades para discutir sobre o lugar com e a partir delas. Por meio desse exercício, identificou-se a necessidade de problematizar essas fotografias presentes no contexto escolar de modo a promover discussões sobre os lugares e o mundo, entendendo-as como potencializadoras e criadoras de pensamento e imaginações geográficas e, portanto, para a educação geográfica.
O RICO E CRIATIVO DEBATE DE CARLOS WALTER PORTO-GONÇALVES COM MARX
Authors: Alentejano Paulo Roberto Raposo , Fontes Virginia
Published: July 2024

Este texto busca resgatar, a partir das relações pessoais do autor e da autora com o homenageado e da leitura de alguns de seus textos, o rico e criativo debate estabelecido por Carlos Walter Porto-Gonçalves, com o pensamento marxiano. Como Carlos nos disse inúmeras vezes, Marx era seu ponto de partida fundamental para a crítica ao capitalismo e às mazelas, violências e destruições produzidas por este. Mas, tal como a melhor tradição de autores marxistas, Carlos não se limitava a repetir as ideias de Marx, apoiava-se nelas para dar sua contribuição à compreensão dos desafios da atualidade, em diálogo com as lutas e os sujeitos destas nos dias de hoje no Brasil e na América Latina.
Self-neglect as a significant public health issue: exploring the responsibility of the SPCDN
Authors: McCabe Georgia , Lavery Joanna
Published: July 2024

Self-neglect is a recognised form of abuse affecting individuals across the lifespan. Gaps are evident within current data to support its prevalence; thus, it is considered to be an under-researched and under-reported phenomenon. Evidence suggests that there are multiple risk factors which contribute to self-neglect and sources recognise it leads to poorer health outcomes. Specialist Community Practitioner District Nurses (SCPDNs) deliver care across a diverse demographic and continuously assess risk for individuals in complex environments leading and managing the care of individuals who self-neglect. It is therefore essential that SCPDNs are equipped with the knowledge and skills required to therapeutically assess the health needs of this patient group and lead on the coordination of care. This article aims to explore the subject of self-neglect as a public health concern and appraise the role and responsibilities of the SCPDN within community nursing practice.
Texting triumph
Authors: Garner Mark
Published: July 2024

Mark Garner emphasises the use of text messaging in keeping patients connected.
A learning opportunity
Authors: Wake Charlotte
Published: July 2024

Charlotte Wake emphasises the importance of meeting the requirements of the ECPD.

Aim

For dental nurses to understand the GDC requirements for ECPD.

Objectives

To explain what is required to meet GDC registration relating to ECPD. To discuss the value of ECPD. To show where ECPD can be accessed.
Assessing the impact
Authors: Symons Anne
Published: July 2024

Anne Symons reviews alcohol's impact on oral health.
The bear necessities
Authors: Brown Clementine Rees , Cassar Paul
Published: July 2024

Clementine Rees Brown speaks with dentist Paul Cassar about his animal rescue mission to help Misha the bear.
Predictors of prognosis in Alzheimer’s disease: The role of cognitive dysfunction, immune abnormalities, and advanced neuroimaging
Authors: Raja Hafsa Arshad , Nashwan Abdulqadir J
Published: July 2024

Alzheimer’s disease (AD) is a grave illness that results in cognitive and social issues. A recent study examined the association between neuroimaging results, cognitive dysfunction, atypical cellular immune function, and poor prognostic factors in AD patients who demonstrated poor prognosis. Poor prognosis was associated with abnormal cellular immune function, extrapyramidal symptoms, altered consciousness, abnormal electroencephalogram, modified Rankin scale, increased neutrophil lymphocyte ratio, and severe pneumonia. The impaired cellular immune function characterized by a reduction in the blood T lymphocytes’ proportion predicted poor prognosis as an independent risk factor in AD. Early initiation and maintenance of AD medications is associated with better outcomes.