bluuebunny/crossref_metadata_2025 huggingface dataset:
Herbicide strategies for weed control in Wisconsin conventional-tillage corn production systems
Authors: Mobli Ahmadreza , DeWerff Ryan P. , Arneson Nicholas J. , Smith Daniel H. , Werle Rodrigo
Published: December 2024

Selection of effective herbicide strategies (i.e., one-pass versus two-pass and timing [preemergence versus postemergence]) is of great importance to corn growers. Field studies were conducted to evaluate overall end-of-season weed control efficacy of multiple herbicide strategies in conventional tillage corn production systems. These studies were carried out over six site-years at four locations in Wisconsin: Arlington (2018 and 2019), Brooklyn (2019), Lancaster (2019), and Janesville (2018 and 2019). Herbicide strategy treatments included one-pass preemergence, one-pass postemergence, two-pass preemergence followed by (fb) postemergence, and two-pass preemergence fb postemergence with layered residual herbicides. The weed species present at the experimental site-years included common lambsquarters, giant foxtail, giant ragweed, velvetleaf, and waterhemp. Except Arlington-2019, the herbicide strategy was not as influential for the site-years infested with common lambsquarters, giant foxtail, velvetleaf, and waterhemp species (e.g., Arlington-2018, Brooklyn-2019, Lancaster-2019), as effective overall end-of-season control (>90%) was achieved regardless of the herbicide strategy, and no significant differences were observed in the combined weed biomass across strategies. A two-pass strategy (e.g., preemergence followed by postemergence, or preemergence followed by postemergence with layered residual herbicides) was necessary for effective overall end-of-season control at the site-years infested with giant ragweed (Janesville-2018 and -2019). Weed interference reduced corn yield by 11% to 75% across site-years. Although certain weed communities can be effectively controlled by a one-pass herbicide strategy, two-pass strategies provided the greatest and most consistent overall end-of-season weed control and corn yield across all site-years, regardless of weed species composition and environmental conditions. Hence, a two-pass herbicide strategy is recommended for conventional-tillage corn production in Wisconsin to ensure effective end-of-season weed control while protecting yield potential of the crop, particularly in fields infested with moderate to high density of troublesome weeds such as giant ragweed.
Creating a Psychological Test in a Few Seconds
Authors: Krumm Stefan , Thiel Alyce M. , Reznik Nomi , Freudenstein Jan-Philipp , Schäpers Philipp , Mussel Patrick
Published: December 2024

Abstract: The development of Situational Judgment Tests (SJTs) is a multi-step procedure that often requires substantial resources and time. ChatGPT as a large language model has already proven helpful for many complex tasks, including the development of psychological questionnaires. However, ChatGPT has so far not been tested for its ability to develop SJT items, which could speed up SJT development and thus contribute to the dissemination of psychometrically well-designed SJTs in practice and also support research requiring specific SJTs or SJT versions. Thus, the current study ( N = 419) examined whether ChatGPT (2023, Feb 13 version using ChatGPT-3.5) can create SJT items, assessing a facet of personality (i.e., gregariousness), that show similar psychometric properties (examined through confirmatory factor, reliability, and correlational analyses) as human-created SJT items. Results revealed that the measurement model for all eleven SJT items that were created by ChatGPT showed a poor model fit, while a reduced set of eight items yielded an acceptable fit. Reliability estimates as well as convergent and discriminant validity evidence were similar for the human-created and the ChatGPT-created SJT. Implications as well as potential boundary conditions of SJT development through ChatGPT are discussed.
Diurnal Variations in Tropical Cyclone Formation and Associated Convective Features
Authors: Hong Jiacheng , Wu Qiaoyan
Published: December 2024

This study investigates the diurnal variations in the formation of tropical cyclones (TCs) and their linkage to convective features. Using best‐track data from 2001 to 2020, it was found that TC formation shows a clear diurnal variation, peaking between 0300 and 0900 local solar time (LST) in most regions. Before a TC forms, the radial gradient in infrared (IR) brightness temperatures (BT) is mainly influenced by the expansion of clouds with IR BT below 208 K. These clouds are most abundant between 0300 and 0600 LST and least abundant between 1500 and 1800 LST. Clouds within 200 km of the circulation center have a higher fraction and greater diurnal variation compared to those located at radii of 200–500 km. A higher fraction of early morning clouds with IR BT < 208 K within 200 km of the circulation center increases the radial IR BT gradient, enhancing the likelihood of TC formation during morning hours.
Tracing Groundwater‐Surface Water Interactions in a Volcanic Maar Lake Using Stable Isotopes and 222Rn
Authors: Esquivel‐Hernández Germain , Montealegre‐Viales Emanuel , Sánchez‐Gutiérrez Rolando , Villalobos‐Forbes Mario , Pérez‐Salazar Roy , Sánchez‐Murillo Ricardo , Mena‐Rivera Leonardo , Birkel Christian , Ortega Lucía
Published: December 2024

Isotope hydrological studies to understand groundwater‐surface water interactions in tropical, high‐elevation catchments are limited. These interactions are important in controlling lake water residence time, aqueous biogeochemistry, and water availability for downstream communities and ecosystems. To better comprehend the complexity of spatio‐temporal variations in the aquifer‐lake domain in tropical volcanic regions, a multi‐tracer approach including water and inorganic carbon stable isotopes (δ2H, δ18O, δ13CDIC), hydrochemistry, and 222Rn was applied in Lake Hule, northern Costa Rica. Seasonal isotope mass balance calculations using lake, stream, precipitation, and groundwater compositions were supplemented with local hydrometeorological information. Evaporation to inflow ratios (E/I) revealed a small variability between the dry (December–April) and wet seasons (May–November), with relatively low evaporation losses, 2.9 ± 1.0 % and 3.2 ± 1.8 %, respectively. Bayesian end‐member analysis indicated that annual inputs from groundwater, precipitation, and runoff represented 61.3 ± 8.1%, 24.4 ± 8.4, and 14.3 ± 5.9% of total lake inflow, respectively. Temporal variations of δ13CDIC confirmed the key role volcanic carbonate buffering plays in this lake and indicated greater CO2 degassing from groundwater sources in the wet season. This tracer‐aided assessment in a volcanic lake maar of northern Costa Rica provides evidence of previously unknown groundwater‐surface water interactions and illustrates the application of isotopic tools for estimating water balances and seasonal variability of groundwater discharge into natural lakes across the volcanic front of Central America.
Radiation Exposure and Shielding Effects on the Lunar Surface
Authors: Matthiä Daniel , Berger Thomas
Published: December 2024

The Moon will be a primary target for human space exploration in the near future. A limiting factor for a crewed mission to the Moon is the radiation dose during their stay on the lunar surface. While the total dose is expected to be dominated by the galactic cosmic radiation (GCR), the potential occurrence of large solar energetic particle events may lead to severe short‐term effects and endanger the success of the mission. This work investigated the expected dose rates for maximum GCR intensity and the total dose from several historical solar energetic particle events, including the NASA reference event, through the application of numerical simulations with the Geant4 Monte‐Carlo framework. An evaluation of the shielding effect of lunar regolith was carried out. For the solar particle events a shielding of more than 4 g/cm2 of regolith would reduce the expected dose to below the current 30‐day limits and a shielding of more than 10 g/cm2 would result in a safety margin factor of two. For GCR adding additional mass shielding did not reduce the absorbed dose significantly. The estimated total dose equivalent received utilizing around 180 g/cm2 of regolith amounted to 200 mSv/year, which is only about 25% below the corresponding estimates for an unshielded environment. The comparison to model and experimental data from literature showed reasonable agreement to measurements but the analysis of various earlier model results revealed, that substantial differences between the models exist, despite all improvements that have been achieved in recent years.
The Impact of Lower Atmosphere Forecast Uncertainties on WACCM‐X Prediction of Ionosphere‐Thermosphere System During Geomagnetic Storms
Authors: Lee Wonseok , Song In‐Sun , Shim Ja Soon , Liu Guiping , Jee Geonhwa
Published: December 2024

Impacts of lower atmosphere forecast uncertainties on the Ionosphere‐Thermosphere (IT) system are investigated using the Whole Atmosphere Community Climate Model with Thermosphere and Ionosphere eXtension (WACCM‐X) for April 2010 and March 2013 geomagnetic storms. For each storm, a specified‐dynamics simulation (analysis run) is carried out by constraining the model dynamics using reanalysis data. Results of the analysis runs are used as initial conditions for forecast runs initialized on 20, 10, 5, 2, and 1 day before the storm onset time. The forecast runs show that errors in TEC compared to the analysis run appear in the equatorial region within 1–2 days after forecast starts with differences of about 10%. These discrepancies gradually expand to high‐latitudes after 10 days. These errors in TECs could be due to the deviations in the semidiurnal (SW2) and non‐migrating (DE3) tides that also occur within 1–2 days after forecast starts. SW2 and DE3 tides could modify the E‐region wind driven dynamo at low latitudes, affecting the vertical plasma drift in the F‐region, leading to the forecast errors in TEC. The TEC forecast errors at high‐latitudes could be due to the change in the column integrated O/N2, associated with tidal wind variations and resultant delayed change in vertical motions. The SW2 and DE3 tides can be affected by uncertainties in winds in the mesosphere and lower thermosphere (MLT) in the mid‐to‐high latitudes. The MLT wind uncertainties are correlated with gravity wave drag (GWD), suggesting that the uncertainties in GWD can be one of the major sources of IT forecast errors.
Unlocking high-performance near-infrared photodetection: polaron-assisted organic integer charge transfer hybrids
Authors: Iqbal Muhammad Ahsan , Fang Xueqian , Abbas Yasir , Weng Xiaoliang , He Tingchao , Zeng Yu-Jia
Published: December 2024

Room temperature femtowatt sensitivity remains a sought-after attribute, even among commercial inorganic infrared (IR) photodetectors (PDs). While organic IR PDs are poised to emerge as a pivotal sensor technology in the forthcoming Fourth-Generation Industrial Era, their performance lags behind that of their inorganic counterparts. This discrepancy primarily stems from poor external quantum efficiencies (EQE), driven by inadequate exciton dissociation (high exciton binding energy) within organic IR materials, exacerbated by pronounced non-radiative recombination at narrow bandgaps. Here, we unveil a high-performance organic Near-IR (NIR) PD via integer charge transfer between Poly[2,5-bis(3-tetradecylthiophen-2-yl)thieno[3,2-b]thiophene] (C-14PBTTT) donor (D) and Tetrafluorotetracyanoquinodimethane (TCNQF4) acceptor (A) molecules, showcasing strong low-energy subgap absorptions up to 2.5 µm. We observe that specifically, polaron excitation in these radical and neutral D-A blended molecules enables bound charges to exceed the Coulombic attraction to their counterions, leading to an elevated EQE (polaron absorption region) compared to Frenkel excitons. As a result, our devices achieve a high EQE of ∼107%, femtowatt sensitivity (NEP) of ~0.12 fW Hz-1/2 along a response time of ~81 ms, at room temperature for a wavelength of 1.0 µm. Our innovative utilization of polarons highlights their potential as alternatives to Frenkel excitons in high-performance organic IR PDs.
Efficacy and safety of lenvatinib plus gefitinib in lenvatinib-resistant hepatocellular carcinomas: a prospective, single-arm exploratory trial
Authors: Shi Yaoping , Cui Dan , Xia Lei , Shi Donghua , Jin Guangxin , Wang Siying , Lin Yan , Tang Xiaoyin , Chi Jiachang , Wang Tao , Li Meng , Lv Zicheng , Zheng Jiaojiao , Jia Qi , Yang Wu , Sun Zhen , Yang Fan , Feng Hao , Yuan Shengxian , Zhou Weiping , Qin Wenxin , Bernards Rene , Jin Haojie , Zhai Bo
Published: December 2024

Lenvatinib, a multi-kinase inhibitor, has been approved as first-line treatment for advanced hepatocellular carcinoma (HCC), but its efficacy is limited. We have shown previously that lenvatinib and epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) combination therapy overcomes lenvatinib resistance in HCC with high level of EGFR expression (EGFRhigh). We present here the results of a single-arm, open-label, exploratory study of lenvatinib plus the EGFR-TKI gefitinib for patients with HCC resistance to lenvatinib (NCT04642547; n = 30). Only patients with EGFRhigh HCC and progressive disease after lenvatinib treatment were recruited in the study. The most frequent adverse events of all grades were fatigue (27 patients; 90%), followed by rash (25 patients; 83.3%), diarrhea (24 patients; 80%), and anorexia (12 patients; 40%). Among 30 patients, 9 (30%) achieved a confirmed partial response and 14 (46.7%) had stable disease according to mRECIST criteria. Based on RECIST1.1, 5 (16.7%) achieved a confirmed partial response and 18 (60%) had stable disease. The estimated median progression free survival (PFS) and overall survival (OS) time were 4.4 months (95% CI: 2.5 to 5.9) and13.7 months (95% CI: 9.0 to NA), respectively. The objective response rate (ORR) of the patients in the present study compares very favorable to that seen for the two approved second line treatments for HCC (cabozantinib ORR of 4%; regorafenib ORR of 11%). Given that this combination was well-tolerated, a further clinical study of this combination is warranted.
The comprehensive SARS-CoV-2 ‘hijackome’ knowledge base
Authors: Huuskonen Sini , Liu Xiaonan , Pöhner Ina , Redchuk Taras , Salokas Kari , Lundberg Rickard , Maljanen Sari , Belik Milja , Reinholm Arttu , Kolehmainen Pekka , Tuhkala Antti , Tripathi Garima , Laine Pia , Belanov Sergei , Auvinen Petri , Vartiainen Maria , Keskitalo Salla , Österlund Pamela , Laine Larissa , Poso Antti , Julkunen Ilkka , Kakkola Laura , Varjosalo Markku
Published: December 2024

The continuous evolution of SARS-CoV-2 has led to the emergence of several variants of concern (VOCs) that significantly affect global health. This study aims to investigate how these VOCs affect host cells at proteome level to better understand the mechanisms of disease. To achieve this, we first analyzed the (phospho)proteome changes of host cells infected with Alpha, Beta, Delta, and Omicron BA.1 and BA.5 variants over time frames extending from 1 to 36 h post infection. Our results revealed distinct temporal patterns of protein expression across the VOCs, with notable differences in the (phospho)proteome dynamics that suggest variant-specific adaptations. Specifically, we observed enhanced expression and activation of key components within crucial cellular pathways such as the RHO GTPase cycle, RNA splicing, and endoplasmic reticulum-associated degradation (ERAD)-related processes. We further utilized proximity biotinylation mass spectrometry (BioID-MS) to investigate how specific mutation of these VOCs influence viral–host protein interactions. Our comprehensive interactomics dataset uncovers distinct interaction profiles for each variant, illustrating how specific mutations can change viral protein functionality. Overall, our extensive analysis provides a detailed proteomic profile of host cells for each variant, offering valuable insights into how specific mutations may influence viral protein functionality and impact therapeutic target identification. These insights are crucial for the potential use and design of new antiviral substances, aiming to enhance the efficacy of treatments against evolving SARS-CoV-2 variants.
The antitumor activity of TGFβ-specific T cells is dependent on IL-6 signaling
Authors: Perez-Penco Maria , Byrdal Mikkel , Lara de la Torre Lucia , Ballester Marta , Khan Shawez , Siersbæk Majken , Lecoq Inés , Madsen Cecilie Oelvang , Kjeldsen Julie Westerlin , Svane Inge Marie , Hansen Morten , Donia Marco , Johansen Julia Sidenius , Olsen Lars Rønn , Grøntved Lars , Chen Inna Markovna , Arnes Luis , Holmström Morten Orebo , Andersen Mads Hald
Published: December 2024

Although interleukin (IL)-6 is considered immunosuppressive and tumor-promoting, emerging evidence suggests that it may support antitumor immunity. While combining immune checkpoint inhibitors (ICIs) and radiotherapy in patients with pancreatic cancer (PC) has yielded promising clinical results, the addition of an anti-IL-6 receptor (IL-6R) antibody has failed to elicit clinical benefits. Notably, a robust TGFβ-specific immune response at baseline in PC patients treated solely with ICIs and radiotherapy correlated with improved survival. Recent preclinical studies demonstrated the efficacy of a TGFβ-based immune modulatory vaccine in controlling PC tumor growth, underscoring the important role of TGFβ-specific immunity in PC. Here, we explored the importance of IL-6 for TGFβ-specific immunity in PC. In a murine model of PC, coadministration of the TGFβ-based immune modulatory vaccine with an anti-IL-6R antibody rendered the vaccine ineffective. IL-6R blockade hampered the development of vaccine-induced T-cells and tumoral T-cell infiltration. Furthermore, it impaired the myeloid population, resulting in increased tumor-associated macrophage infiltration and an enhanced immunosuppressive phenotype. In PC patients, in contrast to those receiving only ICIs and radiotherapy, robust TGFβ-specific T-cell responses at baseline did not correlate with improved survival in patients receiving ICIs, radiotherapy and IL-6R blockade. Peripheral blood immunophenotyping revealed that IL-6R blockade altered the T-cell and monocytic compartments, which was consistent with the findings in the murine model. Our data suggest that the antitumor efficacy of TGFβ-specific T cells in PC depends on the presence of IL-6 within the tumor. Consequently, caution should be exercised when employing IL-6R blockade in patients receiving cancer immunotherapy.
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease
Authors: Jamialahmadi Oveis , De Vincentis Antonio , Tavaglione Federica , Malvestiti Francesco , Li-Gao Ruifang , Mancina Rosellina M. , Alvarez Marcus , Gelev Kyla , Maurotti Samantha , Vespasiani-Gentilucci Umberto , Rosendaal Frits Richard , Kozlitina Julia , Pajukanta Päivi , Pattou François , Valenti Luca , Romeo Stefano
Published: December 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by an excess of lipids, mainly triglycerides, in the liver and components of the metabolic syndrome, which can lead to cirrhosis and liver cancer. While there is solid epidemiological evidence that MASLD clusters with cardiometabolic disease, several leading genetic risk factors for MASLD do not increase the risk of cardiovascular disease, suggesting no causal relationship between MASLD and cardiometabolic derangement. In this work, we leveraged measurements of visceral adiposity identifying 27 previously unknown genetic loci associated with MASLD (n = 36,394), six replicated in four independent cohorts (n = 3,903). Next, we generated two partitioned polygenic risk scores based on the presence of lipoprotein retention in the liver. The two polygenic risk scores suggest the presence of at least two distinct types of MASLD, one confined to the liver resulting in a more aggressive liver disease and one that is systemic and results in a higher risk of cardiometabolic disease. These findings shed light on the heterogeneity of MASLD and have the potential to improve the prediction of clinical trajectories and inform precision medicine approaches.
Soundboard-trained dogs produce non-accidental, non-random and non-imitative two-button combinations
Authors: Bastos Amalia P. M. , Houghton Zachary N. , Naranjo Lucas , Rossano Federico
Published: December 2024

Early studies attempting interspecies communication with great apes trained to use sign language and Augmented Interspecies Communication (AIC) devices were limited by methodological and technological constraints, as well as restrictive sample sizes. Evidence for animals’ intentional production of symbols was met with considerable criticisms which could not be easily deflected with existing data. More recently, thousands of pet dogs have been trained with AIC devices comprising soundboards of buttons that can be pressed to produce prerecorded human words or phrases. However, the nature of pets’ button presses remains an open question: are presses deliberate, and potentially meaningful? Using a large dataset of button presses by family dogs and their owners, we investigate whether dogs’ button presses are (i) non-accidental, (ii) non-random, and (iii) not mere repetitions of their owners’ presses. Our analyses reveal that, at the population level, soundboard use by dogs cannot be explained by random pressing, and that certain two-button concept combinations appear more often than expected by chance at the population level. We also find that dogs’ presses are not perfectly predicted by their owners’, suggesting that dogs’ presses are not merely repetitions of human presses, therefore suggesting that dog soundboard use is deliberate.
Optimal thresholds and key parameters for predicting influenza A virus transmission events in ferrets
Authors: Kieran Troy J. , Sun Xiangjie , Maines Taronna R. , Belser Jessica A.
Published: December 2024

Although assessments of influenza A virus transmissibility in the ferret model play a critical role in pandemic risk evaluations, few studies have investigated which virological data collected from virus-inoculated animals are most predictive of subsequent virus transmission to naïve contacts. We compiled viral titer data from >475 ferrets inoculated with 97 contemporary IAV (including high- and low-pathogenicity avian, swine-origin, and human viruses of multiple HA subtypes) that served as donors for assessments of virus transmission in the presence of direct contact (DCT) or via respiratory droplets (RDT). A diversity of molecular determinants, clinical parameters, and infectious titer measurements and derived quantities were examined to identify which metrics were most statistically supported with transmission outcome. Higher viral loads in nasal wash (NW) specimens were strongly associated with higher transmission frequencies in DCT, but not RDT models. However, viruses that reached peak titers in NW specimens early (day 1 p.i.) were strongly associated with higher transmission in both models. Interestingly, viruses with ‘intermediate’ transmission outcomes (33–66%) had NW titers and derived quantities more similar to non-transmissible viruses (<33%) in a DCT setting, but with efficiently transmissible viruses (>67%) in a RDT setting. Machine learning was employed to further assess the predictive role of summary measures and varied interpretation of intermediate transmission outcomes in both DCT and RDT models, with models employing these different thresholds yielding high performance metrics against both internal and external datasets. Collectively, these findings suggest that higher viral load in inoculated animals can be predictive of DCT outcomes, whereas the timing of when peak titers are detected in inoculated animals can inform RDT outcomes. Identification that intermediate transmission outcomes should be contextualized relative to the transmission mode assessed provides needed refinement towards improving interpretation of ferret transmission studies in the context of pandemic risk assessment.
The role of ER exit sites in maintaining P-body organization and integrity during Drosophila melanogaster oogenesis
Authors: Milano Samantha N , Bayer Livia V , Ko Julie J , Casella Caroline E , Bratu Diana P
Published: December 2024

Processing bodies (P-bodies) are cytoplasmic membrane-less organelles which host multiple mRNA processing events. While the fundamental principles of P-body organization are beginning to be elucidated in vitro, a nuanced understanding of how their assembly is regulated in vivo remains elusive. Here, we investigate the potential link between ER exit sites and P-bodies in Drosophila melanogaster egg chambers. Employing a combination of live and super-resolution imaging, we find that P-bodies associated with ER exit sites are larger and less mobile than cytoplasmic P-bodies, indicating that they constitute a distinct class of P-bodies. Moreover, we demonstrate that altering the composition of ER exit sites has differential effects on core P-body proteins (Me31B, Cup, and Trailer Hitch), suggesting a potential role for ER exit sites in P-body organization. Furthermore, we show that in the absence of ER exit sites, P-body integrity is compromised and the stability and translational repression efficiency of the maternal mRNA, oskar, are reduced. Together, our data highlights the crucial role of ER exit sites in governing P-body organization.
State of the interactomes: an evaluation of molecular networks for generating biological insights
Authors: Wright Sarah N , Colton Scott , Schaffer Leah V , Pillich Rudolf T , Churas Christopher , Pratt Dexter , Ideker Trey
Published: December 2024

Advancements in genomic and proteomic technologies have powered the creation of large gene and protein networks (“interactomes”) for understanding biological systems. However, the proliferation of interactomes complicates the selection of networks for specific applications. Here, we present a comprehensive evaluation of 45 current human interactomes, encompassing protein-protein interactions as well as gene regulatory, signaling, colocalization, and genetic interaction networks. Our analysis shows that large composite networks such as HumanNet, STRING, and FunCoup are most effective for identifying disease genes, while smaller networks such as DIP, Reactome, and SIGNOR demonstrate stronger performance in interaction prediction. Our study provides a benchmark for interactomes across diverse biological applications and clarifies factors that influence network performance. Furthermore, our evaluation pipeline paves the way for continued assessment of emerging and updated interaction networks in the future.
Self-assembled eumelanin nanoparticles enhance IFN-I activation and cilia-driven intercellular communication to defend against Tulane virus, a human norovirus surrogate
Authors: Song Wen , Toh Jillinda , Chen Shurui , Xing Ronge , Li Dan
Published: December 2024

A diagram illustrating the mode of action of EmNPs on cells. The figure depicts the interaction of EmNPs with the cell membrane, their intracellular transport pathways as well as the main mechanisms and pathways of action.
Applications and prospects of indirect 3D printing technology in bone tissue engineering
Authors: Qiao Mingxin , Wu Weimin , Tang Wen , Zhao Yifan , Wang Jian , Pei Xibo , Zhang Bowen , Wan Qianbing
Published: December 2024

This review summarizes the current research advancement and clinical prospects of indirect 3D printing technology in bone tissue engineering, followed by a discussion of its challenges and outlook.
Correction: Stabilizing Ni catalysts in biogas reforming via in situ carbon deposit removal by CeO2 oxygen vacancies
Authors: Gang Yonggang , Zhao Zijiang , Long Yanhui , Li Xiaodong , Zhang Hao
Published: December 2024

Correction for ‘Stabilizing Ni catalysts in biogas reforming via in situ carbon deposit removal by CeO2 oxygen vacancies’ by Yonggang Gang et al., Chem. Commun., 2024, https://doi.org/10.1039/d4cc04453c.
Achieving efficiency above 30% with new inorganic cubic perovskites X2SnBr6 (X = Cs, Rb, K, Na) via DFT and SCAPS-1D
Authors: Rahman Md. Ferdous , Al Galib Tanvir , Rahman Md. Azizur , Rahman Md. Hafizur , Harun-Or-Rashid Md. , Islam Md. Al Ijajul , Islam Md. Monirul , Dhahri N. , Irfan Ahmad
Published: December 2024

The solar sector is shifting towards lead-free, inorganic cubic halide perovskites due to their superior structural, electronic, and optoelectronic properties.
GOCIA: a grand canonical global optimizer for clusters, interfaces, and adsorbates
Authors: Zhang Zisheng , Gee Winston , Lavroff Robert H. , Alexandrova Anastassia N.
Published: December 2024

A versatile, general-purpose, and efficient grand canonical global optimizer for clusters, interfaces, and adsorbates.
Singlet (1Δg) O2 initiated gas phase oxidation as a potential tropospheric decay channel for ketene
Authors: Sarkar Saptarshi , Dhiman Ashray , Bandyopadhyay Biman
Published: December 2024

The title reaction could be adequately fast to play key role in the tropospheric loss mechanism of simplest ketene in locations where concentration of singlet oxygen significantly exceeds that of hydroxyl radical.
Twin hydrogen bonds with phosphine oxide: anticooperativity effects caused by competing proton donors
Authors: Kostin Mikhail A. , Alkhuder Omar , Asfin Ruslan E. , Tolstoy Peter M.
Published: December 2024

The anticooperativity of two H-bonds with phosphine oxide increases nonlinearly with the bond strength and can be estimated from the shifts of 1H, 31P NMR signals and PO stretching frequency.
Improved thermoelectric efficiency of Sb2Si2Te6 through yttrium-induced nanocompositing
Authors: Saglik Kivanc , Tan Xian Yi , Dong Jinfeng , Suwardi Ady , Wang Xizu , Xu Jianwei , Zhu Qiang , Liu Hongfei , Cao Jing , Yan Qingyu
Published: December 2024

Sb2Si2Te6 is a promising 2D material for medium-temperature thermoelectric applications, with the thermoelectric figure of merit zT approaching 1 at 823 K.
MatFold: systematic insights into materials discovery models' performance through standardized cross-validation protocols
Authors: Witman Matthew D. , Schindler Peter
Published: December 2024

A general-purpose, featurization-agnostic toolkit, MatFold, is provided to automate reproducible generation of cross-validation splits to assess out-of-distribution generalization and encourage further community use in materials model benchmarking.
27Al NMR chemical shifts in zeolite MFI via machine learning acceleration of structure sampling and shift prediction
Authors: Willimetz Daniel , Erlebach Andreas , Heard Christopher J. , Grajciar Lukáš
Published: December 2024

Accurate prediction of 27Al NMR chemical shifts in zeolites at operating conditions via a combination of neural network potential-driven dynamics sampling relevant structures and regression models for shift prediction.
Comprehensive sampling of coverage effects in catalysis by leveraging generalization in neural network models
Authors: Schwalbe-Koda Daniel , Govindarajan Nitish , Varley Joel B.
Published: December 2024

A combination of generalization in neural networks and fast data pipelines enables comprehensive sampling coverage and co-adsorption effects in heterogeneous catalyst models.
Extraction and complexation of trivalent americium and lanthanides using an asymmetric picolinic acid-derived tridentate N,O-hybrid ligand
Authors: Cao Hong , Guo Yuxiao , Li Bin , Tang Qilong , Hao Huaixin , Wang Zhipeng , Xu Chao
Published: December 2024

The extraction and complexation of trivalent americium (Am) and lanthanides (Ln) using an asymmetric picolinic acid-derived tridentate N,O-hybrid ligand, DOAPA, have been studied through both experimental and theoretical methods.
Of perfluorinated aryllead(ii) complexes
Authors: Someşan Adrian-Alexandru , Roisnel Thierry , Sarazin Yann
Published: December 2024

The new organometallic lead(ii) plumbate 1 and the polymer [Pb(C6F5)2(dx)]∞ (2) are validating once again that Pb(ii) chemistry has its own particularities with respect to its lighter congener, Sn(ii).
Determination of Pb2+ in natural water with a polymer electrode coupled with a flow analysis device
Authors: Zhang Guiyun , Lai Zhiwei
Published: December 2024

A designed flow analysis device was used for the determination of Pb2+ in natural water coupled with a poly(pyrrole thiourea) electrode, and this method is suitable for application to drinking water detection.
Complexation of starch and konjac glucomannan during screw extrusion exhibits obesity-reducing effects by modulating the intestinal microbiome and its metabolites
Authors: Liu Fanrui , Wan Hao , Fan Honghao , Zhang Zhihong , Dai Hua , He Hai
Published: December 2024

The ERS–KGM complex improves gut health, reduces obesity markers, enhances glucose metabolism, and positively alters gut microbiota, showing potential as an obesity-preventive supplement.
Polymer-based solid electrolyte interphase for stable lithium metal anodes
Authors: Airoldi Martino , Berrocal José Augusto , Gunkel Ilja , Steiner Ullrich
Published: December 2024

Lithium metal battery anodes have been stabilized by grafting a polymer brush onto a hydroxide layer formed by controlled exposure to water vapor, effectively preventing dead lithium aggregates and dendritic growth during cycling.
Polydopamine-assisted decoration of silver nanoparticles on gold nanorods for photothermal and chemical antimicrobial applications
Authors: Zhao Yuting , Zhan Ke , Geng Pengshan , Jiang Shan
Published: December 2024

AuNRs@PDA@AgNPs were prepared by assembling AgNPs on AuNRs with the assistance of PDA, realizing synergistic photothermal and chemical sterilization.
Manganese carbonyl-encapsulated Fe-MOFs as a H2O2-responsive CO gas nanogenerator for synergistic gas/chemodynamic therapy
Authors: Wang Fengqin , An Jian , Zhang Shiyue , Ma Jingjing , Liang Xufeng , Zhang Jianxia , Pu Jia , Meng Yujia , Bai Yiqiao , Yu Wenqiang , Gao Yunhan , Jiang Yingfang , Chen Tingting , Yao Yong , Wang Yang
Published: December 2024

A glucose oxidase-amplified CO gas-releasing nanoplatform was designed using a manganese carbonyl-caged metal–organic framework for synergistic gas/chemodynamic therapy of cancer cells.
Harnessing mixed-phase MoS2 for efficient room-temperature ammonia sensing
Authors: Jalil M. A. , Hassan Kamrul , Tran Anh Tuan Trong , Tung Tran Thanh , Panda Manas Ranjan , El Meragawi Sally , Kida Tetsuya , Majumder Mainak , Losic Dusan
Published: December 2024

Hydrothermally synthesized Mixed-phase MoS2 (1T@2H-MoS2), with sulfur vacancies, enables rapid (7 s) and selective NH3 sensing (2–100 ppm) at 20 °C, overcoming MoS2’s insulating limits and highlighting potential for industrial safety monitoring.
A roller-type triboelectric nanogenerator based on rotational friction between wool and stacked interfaces for omnidirectional wind energy harvesting
Authors: Su Xiaonan , Su Yuxiang , Yan Hongjun , Zhang Xinyao , Dai Guanyu , Dong Xin , Wu Jinlin , Zhao Xizeng , Zhao Keyang , Li Zhenhua
Published: December 2024

It is urgently desired to develop high-performance wind energy collectors to power numerous microelectronic devices along with the Internet of Things (IoT).
Correlating photochemical H2 production and excited state lifetimes of heterostructured and doped ZnCdS nanoparticles
Authors: Fortunato Mathew T. , O'Shea Joseph M. , Huang Jie , Chandrasiri Hashini , Kim Eun Byoel , Jamhawi Abdelqader M. , Ayitou A. Jean-Luc , Snee Preston T. , Turro Claudia
Published: December 2024

A variety of ZnCdS-based semiconductor nanoparticle heterostructures with extended exciton lifetimes were synthesized to enhance the efficacy of photocatalytic hydrogen production in water.
Gelation-free synthesis of high-molecular-weight hyperbranched aromatic polymers containing silicon by Suzuki–Miyaura polycondensation of tri- or tetra(bromoaryl)silane with arylenediboronate
Authors: Shimada Ryusuke , Kubota Masato , Ohta Yoshihiro , Yokozawa Tsutomu
Published: December 2024

The titled polycondensation in the presence of tBu3PPd precatalyst proceeds through intramolecular Pd catalyst transfer on the silyl group and π-face of the bromide, affording silicon-containing hyperbranched aromatic polymers without gelation.
Effect of macromonomer chemical structure on the rate of grafting-through ring-opening metathesis polymerization
Authors: McCleary-Petersen Keelee C. , Feng Yating , Guironnet Damien
Published: December 2024

We present unexpected observations where the rate of ring-opening metathesis polymerization (ROMP) is affected by the macromonomer polymer chain rather than the anchor group. We also observe that faster ROMP rate does not ensure better “livingness”.
LuCl3/ZnI2 cocatalyzed 1,1-diborylation of terminal alkynes to 1,1-diborylalkenes with pinacolborane
Authors: Zhou Rongrong , Wang Wenli , Zhang Jianping , Wang Qi , Chen Ziyan , Shao Yinlin , Zhang Fangjun
Published: December 2024

A method was developed using LuCl3/ZnI2 to cocatalyze the 1,1-diboration of simple terminal alkynes, producing from moderate-to-good yields of 1,1-diborylalkenes.
Efficient light-induced reactive oxygen species production from a far-red ER-targeting BODIPY dye
Authors: Swavey Shawn , Quentel Arnaud , Grzesiak Matthew , Hawkins Cate , Vidi Pierre-Alexandre
Published: December 2024

One-pot synthesis of a new ER-localizing BODIPY photosensitizer operates by a Type I and Type II mechanism.
Sunlight-activated heterostructure MoS2/CdS nanocomposite photocatalyst with enhanced photocatalytic activity: band alignment and mechanism study
Authors: Hamid Kaysar , Bin Mukhlish Muhammad Zobayer , Uddin Md. Tamez
Published: December 2024

Charge separation mechanism at the interface of MoS2/CdS hetrojunction.
Influence of ultrafast laser processing on amorphous structures – based on molecular dynamics simulation
Authors: Liu Shijia , Liu Jiaqi , Liu Jialin , Chen Jiuye
Published: December 2024

Molecular dynamics simulations of ultrafast laser processing show alloy nucleation and growth in 10 nanoseconds, with rapid energy deposition shortening phase transformation and higher temperatures reducing the amorphous phase.
Advances in nanotechnology-based approaches for the treatment of head and neck squamous cell carcinoma
Authors: Tang Bicai , Huang Rui , Ma Wenjuan
Published: December 2024

Emerging nanoparticles (NPs), including biomembrane-based, polymeric, metallic, and non-metallic inorganic NPs, have offered powerful and promising approaches for the diagnosis and treatment of head and neck squamous cell carcinoma (HNSCC).
Metallic nickel-anchored biochar with non-metallic heteroatom modification: remarkably effective catalyst for steam reforming of methane
Authors: Zhao Yu-e , Li Jinxiao , Xu Ao , Liu Yulong , Lian Minghui , Zhang Jing , Zhong Hexiang , Yang Chunhua , Song Rensheng , Pan Liwei
Published: December 2024

In this paper, the effect of H3PO4-activated biochar on nickel-based catalysts for steam methane reforming (SMR) was explored. FTIR, BET, XRD, Raman, TEM, HRTEM, H2-TPR and XPS analyses were used to characterize supports and catalysts.
Competition between ammonia and nitrogen oxides during nitrogen fixation using N2 and H2O plasma without catalysis
Authors: Wang Yuanyuan , Sun Bing , Yu Zhonglin , Sun Shaohua , Liu Jinglin , Xin Yanbin , Zhu Xiaomei
Published: December 2024

The H2O content in the gas phase can affect the distribution of nitrogen fixation products in the gas–liquid mixed discharge plasma.
Advances in metal/zeolite catalysts for C1–C8 alkane dehydroaromatization
Authors: Zhai Yi , Li Wenqian , Wu Qinming , Sheng Na , Xiao Feng-Shou
Published: December 2024

The development of metal/zeolite catalysts for C1–C8 alkane dehydroaromatization was reviewed. The outlook for the design of metal/zeolite catalysts for alkane dehydroaromatization and deep understanding of the reaction mechanism were proposed.
A review of large language models and autonomous agents in chemistry
Authors: Ramos Mayk Caldas , Collison Christopher J. , White Andrew D.
Published: December 2024

This review examines the roles of large language models (LLMs) and autonomous agents in chemistry, exploring advancements in molecule design, property prediction, and synthesis automation.
Potassium escaping balances the degree of graphitization and pore channel structure in hard carbon to boost plateau sodium storage capacity
Authors: LeGe Niubu , Zhang Ying-Hao , Lai Wei-Hong , He Xiang-Xi , Wang Yun-Xiao , Zhao Ling-fei , Liu Min , Wu Xingqiao , Chou Shu-Lei
Published: December 2024

This work revealed the dual beneficial roles of potassium, acting as a self-template to create pore channels and balancing the degree of graphitization.
Hydroformylation, hydroaminomethylation and related tandem reactions of bio-derived renewable olefins: a step closer to sustainability
Authors: Prajapati Rupali S. , Bhanage Bhalchandra M.
Published: December 2024

Biomass-derived renewable olefins act as sustainable and cost-effective starting materials in the production of industrially valuable chemicals, such as aldehydes, amines and other compounds, through hydroformylation and related one-pot reactions.
Multi-scale quantitative investigation of the early structural transformation mechanism in alkali-activated materials: insights from molecular dynamics and first-principles calculations
Authors: Huang Jiazhi , Wang Baomin , Zhang Shipeng
Published: December 2024

The polycondensation process of alkali-activated materials has been evaluated in real-time at the molecular level.
Solvent-free lithium-ion battery electrodes with ultrahigh loading using a reactive epoxy nanobinder
Authors: Zhu Pingwei , Liu Siqi , Zhao Lei , Liu Li , Huang Yudong , Li Jun , Li Fujun
Published: December 2024

EPs provide strong bonding to LTO through covalent bonds. A series of HDEs with gradient mass loadings were prepared, achieving a maximum mass loading of 31 mg cm−2, corresponding to an areal capacity of 3.6 mA h cm−2.
Mode of electroactive species evolution from Fe3X4 (X = Se, S, O): guidelines from the redox chemistry of chalcogen anions
Authors: Kundu Avinava , Gautam Simmi , Chakraborty Biswarup
Published: December 2024

The redox and aqueous speciation chemistry of chalcogenides present in the Fe3X4 (X = Se, S, O) structure also controls the electrochemical evolution of the reactive phase for alkaline oxygen evolution reaction.
Iridium-incorporated cobalt hydroxide electrodeposited on titanium meshes enabling electroreduction of nitrate and nitrobenzene to ammonia and aniline
Authors: Yan Jingwen , Wu Song , Zhao DongLin , Li Dandan , Fan Guangyin , Long Yan , Yu Xiaojun
Published: December 2024

An Ir-incorporated cobalt hydroxide electrodeposited on titanium meshes (Ir@Co(OH)2/TM) is developed to achieve efficient removal of nitrogen-containing pollutants, while simultaneously synthesizing high-value ammonia and aromatic amines.
Reverse design of high-detonation-velocity organic energetic compounds based on an accurate BPNN with wide applicability
Authors: Wu Qiong , Dong Guan-chen , Wang Shuai-yu , Wang Xin-yu , Yan Bin , Zhu Wei-hua , Lv Jing , Tan Ling-hua
Published: December 2024

Key factors affecting detonation velocity (D) are identified with machine learning (2% error), and high-D energetic compounds are designed.
Application of downshifting and antireflection stacked layers synthesized using a wet chemistry method with broad UV excitation for silicon heterojunction solar cells
Authors: Zhao Xiaowen , Xu Chuangen , Wei Jindi , Wang Haobo , Yang RuiPeng , Wang Xiaoliang , Ye Xiaojun
Published: December 2024

Downshifting and antireflection materials enhance the short-circuit current density of the solar cell module while reducing ultraviolet degradation in SHJs.
A robust, efficient ion transport polytetrafluoroethylene fibrous membrane-based separator with superior stability for ultralong-life zinc ion hybrid supercapacitors
Authors: Wei Zhiqian , Huang Biao , Song Lixin , Chen Yijian , Du Pingfan , Zhu Hailin , Xiong Jie , Guo Yuhai
Published: December 2024

A robust and efficient ion transport PTFE-based separator with superior stability was fabricated for zinc ion hybrid supercapacitors, demonstrating excellent electrochemical performance.
Selective gas phase pulsed etching of oxides with NbCl5
Authors: Ojala Juha , Vehkamäki Marko , Chundak Mykhailo , Vihervaara Anton , Mizohata Kenichiro , Ritala Mikko
Published: December 2024

NbCl5 was found to be a highly selective vapor phase etchant for Ta2O5, TiO2 and ZrO2. The mechanism of Ta2O5 etching was proven with thermodynamic and QMS studies, and selectivity was demonstrated on a patterned Al2O3/Ta2O5 double layer.
Aerogel for random lasing and sensors with thermal insulation
Authors: Hu Zhijia , Wang Zhiruo , Li Xiaoyu , Qu Guangyin , Cao Zhigang , Li Siqi , Kuai Yan , Xia Jiangying , Yu Benli
Published: December 2024

This work produced a polymer aerogel with excellent thermal insulation properties that can be applied to random lasing and fiber optic sensing.
Device Use Among Spanish–English Bilingual and English Monolingual Children Who Are Deaf and Hard of Hearing
Authors: Wiseman Kathryn B. , Cowan Tiana M. , Calandruccio Lauren , Walker Elizabeth A. , Rodriguez Barbara , Oleson Jacob J. , McCreery Ryan W. , Leibold Lori J. , Buss Emily
Published: December 2024

Purpose:

This report compares device use in a cohort of Spanish–English bilingual and English monolingual children who are deaf and hard of hearing, including children fitted with traditional hearing aids, cochlear implants (CIs), and/or bone-conduction hearing devices.

Method:

Participants were 84 Spanish–English bilingual children and 85 English monolingual children from clinical sites across the United States. The data represent a subset obtained in a larger clinical trial. Device use obtained via data logging was modeled as a function of language group, device type, child age, sex, and parental education.

Results:

Among children with traditional hearing aids, bilingual children wore their devices significantly fewer hours per day than monolingual children, but this group difference was not observed for children with CIs or bone-conduction hearing devices. In the monolingual group, older children wore their devices significantly more hours than younger children, but this effect of age was not present in the bilingual group. Parent report was consistent with data logging for bilingual and monolingual children.

Conclusions:

Spanish–English bilingual hearing aid users wore their devices less than their English monolingual peers, particularly among older children. This group effect was not observed for children with CIs or bone-conduction hearing devices. Additional studies are needed to identify factors that contribute to device use among bilingual children with hearing aids.
12b 500MS/s successive‐approximation‐register‐assisted pipeline analogue‐to‐digital convertor using a four‐stage ring amplifier with coarse‐analogue‐to‐digital convertor embedded
Authors: Liu Linghao , Ren Junyan , Ye Fan
Published: December 2024

This article presents a 12b 500MS/s successive‐approximation‐register‐assisted pipeline analogue‐to‐digital converter. By adopting a new auto‐zero scheme, a calibration‐free four‐stage ring residue amplifier with a small offset cancellation capacitor is proposed. In addition, the coarse‐analogue‐to‐digital converter of the second stage is embedded into the amplification phase, which relaxes the comparison periods of the first and second stages by 25.0% and 17.4%, respectively. Post‐simulated in 28‐nm CMOS technology with a 0.9 V supply, the analogue‐to‐digital converter achieves 62.2 dB SNDR and 78.1 dB SFDR. It consumes 8.45 mW with an on‐chip reference voltage buffer, resulting in Schreier's figure of merit (FoMS) of 166.9 dB.