bluuebunny/crossref_metadata_2025 huggingface dataset:
Pulsed Radiofrequency Neuromodulation of the Sciatic Nerve in the Management of Posttraumatic Sciatic Neuritis
Authors: Matche Pratibha , Deva Radhika , Sowmya L. N.
Published: August 2024

Accidental intraneural injection causing nerve injury is an iatrogenic catastrophe. Intramuscular injection (IM) is a common injury affecting the sciatic nerve. Sciatic nerve injury manifests as radicular pain with paraesthesia accompanied by an immediate onset of motor and sensory deficits. Treatment options include medical management with corticosteroids, neuropathic medications, and surgical exploration with or without anastomosis. We report a case of a young boy who presented with shooting pain with Numerical Rating Scale of 8/10 from the left buttock up to the left foot following accidental IM injection. The pain was associated with sensory loss over the left foot. Since he was unresponsive to medical management with corticosteroids and neuropathic medications, he was treated with pulsed radiofrequency neuromodulation of the left sciatic nerve. He responded well for the treatment and was discharged with good pain relief.
Experience with Gore’s Block in Patients with Lower Lumbar Radiculopathy
Authors: Devalkar Priti , Salgaonkar Sweta , Kothari Kailash , Singhal Isha
Published: August 2024

Lower lumbar radiculopathy is one of the most common presentations in the pain clinic outpatient department (OPD). A thorough history, physical examination, neurological assessment, and imaging help in the diagnosis and management. The inability to identify the correct pain generator often causes a failure of treatment. Dr. Satishchandra Gore has proposed a new method for the diagnosis of affected lower lumbar nerve root (L5 and S1) at a peripheral level. His hypothesis is that in an inflamed nerve root, sodium channels are upregulated at both proximal and distal ends (central and peripheral). This results in tenderness at the distal peripheral end of the nerve on palpation. We can block the sodium channels at the distal portion of the same inflamed nerve, which may be able to abolish pain. This procedure is called “Gore’s Block” and the result is called “Gore’s sign.” We used this technique in 10 patients with suspected L5-S1 radiculopathy. Out of 10 patients, seven patients had pain relief after Gore’s block. These seven patients also responded well to a Caudal epidural steroid injection. Two patients did not have significant pain relief with Gore’s block and had poor responses to epidural steroid injections. One patient got therapeutic pain relief after Gore’s block, probably due to the natural resolution of the disease. Gore’s block is a simple, OPD procedure, helpful in diagnosing the level of nerve affection in lower lumbar radiculopathy. It is diagnostic and has a good correlation with epidural blocks. Whether it is therapeutic in nature needs to be further investigated.
The effect of oral sodium bicarbonate on the improvement of interdialytic acidosis and hyperkalemia in prevalent hemodialysis patients
Authors: Abd El Wahab Khaled G. , El Hamid El Shennawy Howaida A. , El Wahab Saeed Saeed A. , El Deeb Manal , Soliman Ammar Y. , Mansour Amr M.
Published: August 2024

Background

Uremic toxins closely fit the saw-toothed profile including electrolytes, such as potassium, which is statistically associated with peri-dialytic morbidity and mortality. Acidosis follows a similar inverse pattern, with the bicarbonate levels gradually falling during the inter-dialytic period, before rapid supplementation during dialysis. Observational studies of clinical outcomes support the view that acidosis is harmful, showing that, after adjustment for comorbidity, pre-dialysis bicarbonate levels (HCO3) below 22 mmol/l are associated with excess mortality. The aim of this work is to study the effect of oral sodium bicarbonate supplementation on improvement of interdialytic acidosis, and hyperkalemia in patients on regular hemodialysis (HD).

Patients and methods

This was a one-arm interventional study that was conducted on a group of 50 adult end-stage renal disease patients on regular HD 3 times weekly at least for 3 months.

Results

Our study population’s mean ages were 41.8 ± 10.5 years, with male predominance 58%. PH value before and after sodium bicarbonate supplementation was 7.29 ± 0.07 and 7.38 ± 0.05, respectively, with level change 0.09 ± 0.06, which was statistically significant. Bicarbonate levels before and after sodium bicarbonate supplementation were 18.0 ± 1.8 and 23.4 ± 2.1(mmol/l), respectively, with level change 5.4 ± 1.7 (mmol/l), which was statistically significant. Also, potassium level (K) before and after sodium bicarbonate supplementation was 5.4 ± 0.5 and 5.0 ± 0.4 (mmol/l) respectively with level change –0.4 ± 0.3 (mmol/l), which was statistically significant. Regarding interdialytic body weight before and after sodium bicarbonate supplementation was 75.6 ± 6.5 and 75.5 ± 6.7 (kg), respectively, its change was –0.1 ± 0.5 (kg), which was statistically nonsignificant. As regards systolic blood pressure before and after sodium bicarbonate supplementation was 123.8 ± 11.4 and 125.6 ± 14.3 (mmHg), respectively, its change was 1.8 ± 9.4 (mmHg), which was statistically nonsignificant. Diastolic blood pressure before and after sodium bicarbonate supplementation was 76.0 ± 7.6 and 77.0 ± 8.1 (mmHg), respectively, and its change was 1.0 ± 9.5 (mmHg), which was statistically nonsignificant.

Conclusion

Oral sodium bicarbonate supplementation is effective in correcting interdialytic metabolic acidosis (PH and bicarbonate level) and hyperkalemia in HD patients without causing any significant increase in interdialytic body weight or systolic-diastolic blood pressure.
Convulsive Patients Transported by a Physician-staffed Helicopter in Japan Had Better Outcomes in the Keyword-triggered Dispatch Compared to Postcontact Emergency Medical Technician-triggered Dispatch
Authors: Kawai Kenji , Nagasawa Hiroki , Nomura Tomohisa , Sugita Manabu , Yanagawa Youichi
Published: August 2024

Introduction:

We retrospectively analyzed convulsive patient outcomes transported by a physician-staffed Helicopter Emergency Medical Service (doctor helicopter [DH]) using the keyword-triggered dispatch with data from the Japan DH Registry System (JDRS). Upon receiving an emergency call containing critical keywords, such as an ongoing convulsion at the firefighting central command room, immediate dispatch of the DH is requested, in addition to dispatching an ambulance. The keyword-triggered dispatch relied on data obtained from the JDRS.

Methods:

Details from the JDRS database included patient age, sex, cardiac arrest presence upon DH contact, vital signs, DH dispatch timing (keyword-triggered dispatch/emergency medical technician [EMT]-triggered dispatch), medical intervention details, and 1-month outcomes (cerebral performance category [CPC]; CPC1, 2: Good; CPC 3–5: Poor). Subjects were divided into keyword (keyword-triggered dispatch) and control (EMT-triggered dispatch) groups for comparison.

Results:

Of 1201 patients, all evacuated from the scene, 617 were in the keyword group, and 584 in the control group. No significant differences existed between groups for cardiac arrest, respiratory and heart rates, CPC, or mortality. The keyword group had lower average age, systolic blood pressure, and medical intervention ratio but a higher median Glasgow Coma Scale and good outcome ratio.

Conclusion:

This first report on the keyword-triggered dispatch as a prognostic factor for convulsive patients evacuated by DH using the JDRS.
Lemierre’s Syndrome Complicated by Venous Stroke due to a Massive Cerebral Venous Thrombus
Authors: Nakahara Sayaka , Obata Kaoru , Ikegami Tetsunori
Published: August 2024

Lemierre’s syndrome is a rare disease characterized by thrombophlebitis of the internal jugular vein and metastasis to distant organs. It occurs after an anaerobic infection of the larynx or dental region; the central nervous system involvement is infrequent. A 50-year-old woman presented with impaired consciousness. She had undergone several days of dental treatment for a toothache before presentation. Contrast-enhanced computed tomography (CT) revealed a head-and-neck abscess and a massive thrombus in the internal jugular vein, and a diagnosis of Lemierre’s syndrome was made. After symptoms improved with surgical drainage and antimicrobial therapy, the patient was discharged on day 58. In this case, Lemierre’s syndrome was complicated by a venous stroke caused by venous congestion due to a massive cerebral venous thrombus. Venous stroke due to thrombi may occur in patients with Lemierre’s syndrome, and magnetic resonance imaging or CT with venous phase imaging may aid in the diagnosis.
Comparative Effect of Chair Calisthenics, Yoga, and Chest Physiotherapy on Exercise Tolerance, Quality of Life, and Duration of Hospital Stay in Hospitalized Chronic Obstructive Pulmonary Disease Patients
Authors: Gurudut Peeyoosha , Ozha Sakshi , Passanha Risia , Patel Shivani
Published: August 2024

Aims:

Previous studies have inferred that calisthenics, yoga, and chest physiotherapy (CPT) are effective in managing chronic obstructive pulmonary disease (COPD) patients. However, there are no studies done to compare calisthenics, yoga, and CPT. The aim of this study was to compare the effect of calisthenics exercises, yoga, and CPT on exercise tolerance, fatigue level, quality of life (QOL), and duration of hospital stay in COPD patients.

Subjects and Methods:

This study was an assessor-blinded, randomized, controlled trial. Data were collected from the inpatient department of a tertiary care hospital in Belagavi. Thirty-three patients diagnosed with COPD were divided randomly into calisthenics, yoga, and CPT groups. Outcomes were assessed for exercise tolerance, breathlessness, lung capacity, and QOL. Within-group analysis was done using the Wilcoxon signed-rank test/paired t-test. Between-group comparison was done using the ANOVA/Kruskal–Wallis test. Post hoc test was used to find which specific group was better than the others.

Results:

Between-group analyses showed that calisthenics was better than CPT (P < 0.001) to improve lung capacity, whereas calisthenics and yoga showed equal effect in improving lung capacity.

Conclusions:

Calisthenics, yoga, and CPT are equally effective in improving exercise tolerance, QOL, and perceived exertion. Calisthenics and yoga are equally effective and better than CPT in improving lung capacity of patients with COPD.
Palmar Dermatoglyphic Pattern in Relation to Blood Group and Gender in Saudi Population
Authors: Ghaffar Usama B.
Published: August 2024

ABSTRACT

Background:

Forensic medicine deals with the identification of individuals, but it also involves legal documents, financial transactions, and civil affairs. One of the most established and trustworthy biometric techniques is the fingerprint, which is accepted as valid identification documentation for individuals.

Methods:

This cross-sectional research involved 420 Saudi students, including 300 males and 120 females, aged between 18 and 27. On a white A4-sized Performa, rolled imprints of each participant’s ten fingers were obtained, and these were categorized into loops, whorls, arches, and composites. The relationship between the ABO and Rh blood groups and fingerprint patterns were compared using the Chi-square test to see for any correlation.

Results:

The study included 420 participants in total. Of these 420, there were males 300 (71.4%), and females 112 (28.6%) participants, respectively. Of the 420 participants, blood groups, such as A, B, AB, and O, were represented by 112 (26.7%), 75 (17.8%), 20 (4.8%), and 213 (50.7%) of the participants, respectively. Out of the 4200 fingerprints, 127 (3.0%) were composite, 1547 (36.8%) were whorl, 197 (4.7%) were arch, and 2329 (55.5%) were loop. An analysis of the fingerprint patterns of the ABO blood group revealed a statistically significant variance (P = 0.0002).

Conclusion:

According to this study, the most common fingerprints were loop (55.5%) and whorl (36.8%). ABO blood group differences in fingerprint patterns were found to be statistically significant.
Case Report on Ocular Prosthesis: A Comprehensive Review
Authors: Almudarris Ban Ahmed , Sharma Rakesh , Sreenivasalu Pavan K. Pavagada , Naik Rutika , Kharat Swati , Laddha Rashmi
Published: August 2024

ABSTRACT

Ocular prostheses play a crucial role in restoring the form, function, and esthetics of individuals who have undergone trauma or have congenital defects. This case report presents the fabrication and successful application of a ocular prosthesis for a patient who had suffered loss of eye due to trauma in his childhood days. The prosthesis provided the patient with improved facial symmetry, and psychological well-being. The fabrication process, materials used, and clinical outcomes are discussed in detail, along with a review of relevant literature on ocular prostheses.
Estimation of Total Length of the Femur from its Distal Segmental Measurements in Adult Population: A Morphometric Study
Authors: Kaur Swarnjeet , Kaur Harsimarjit , Agnihotri Gaurav
Published: August 2024

ABSTRACT

Aims and Objectives:

The aim of the study was to estimate the entire length of the femur from the parameters of its lower end after determining their association.

Methods and Materials:

The study used 200 mature, dry, completely ossified femora from an unknown sex. Twelve parametric variables related to the lower end were discovered. The measurements collected were statistically examined.

Results:

The measurements differed on both sides; however, the differences were not statistically significant except for the distal segment’s total length, lateral condyle height, and circumference. All of the parametric factors at the lower end of the femur show a positive relationship with the overall length of the distal segment, and a regression equation has been established.

Conclusions:

The study provides a thorough analysis of the morphometry of the lower end of the femur. These criteria can be utilized to develop knee prostheses and plates appropriate for the adult population.
Retrospective Review of Treatment Outcomes in Epilepsy Patients: Seizure Control and Medication Side Effects
Authors: Naveen P , Sarala G , Chandra D. Manoj , Dutta Riddhiman , Satodiya Vimal , Imran Rangraze , Pandey Pritee Rajkumar
Published: August 2024

ABSTRACT

Background:

Epilepsy management requires balancing seizure control with minimizing medication side effects. This retrospective review examines treatment outcomes in epilepsy patients, focusing on seizure control and medication-related adverse effects.

Methods:

Medical records of epilepsy subjects treated tertiary care center between 2017 and 2022 were retrospectively reviewed. Data on demographic characteristics, seizure control, medication regimen, and side effects were collected and analyzed.

Results:

A total of 200 subjects were included. Sixty percent of subjects achieved total seizure independence, 30% reduced seizure frequency, and 10% did not improve or deteriorate. The kind of antiepileptic medicine provided substantially affects prescription side effects (P < 0.05), with drug X causing more dizziness than drug Y (P = 0.02). Elderly individuals were more likely to suffer weariness than younger ones (P = 0.03).

Conclusion:

This review provides valuable insights into epilepsy treatment outcomes, emphasizing the need for personalized management strategies to optimize seizure control while minimizing medication-related adverse effects.
Effectiveness of Different Behavior Management Techniques in Pediatric Dentistry
Authors: Verma Rajnish Kumar , Sindgi Rutuja , Gavarraju Deepthi Nirmal , Manasa Pappu Lakshmi , Bakkuri Prashanth Kumar , Dubey Alok , Ravula Sandeep Reddy
Published: August 2024

ABSTRACT

Background:

Pediatric dentistry necessitates efficient behavior management methods to ensure successful treatment outcomes and positive experiences for young patients. This research aims to evaluate the comparative effectiveness of “Tell-Show-Do (TSD)”, positive reinforcement, nitrous oxide sedation, and pharmacological sedation in pediatric dental practice.

Methods:

A retrospective analysis was conducted on pediatric patients aged 3-12 years who underwent dental treatment at a designated dental center over a 1-year period. Patients were categorized based on the behavior management method utilized: TSD, positive reinforcement, nitrous oxide sedation, or pharmacological sedation. Treatment success rates and patient cooperation levels were evaluated for each method.

Results:

Positive reinforcement and TSD demonstrated the highest treatment success rates (85% and 80%, respectively) and patient cooperation levels (90% and 85%, respectively). Nitrous oxide sedation exhibited moderate effectiveness with a treatment success rate of 70% and a patient cooperation level of 75%. Pharmacological sedation had the lowest treatment success rate (60%) and patient cooperation level (65%). Statistical analysis revealed significant differences in treatment success rates (P < 0.05) and patient cooperation levels (P < 0.05) among the behavior management methods.

Conclusion:

Positive reinforcement and TSD emerge as highly efficient behavior management methods in pediatric dentistry, promoting high treatment success rates and patient cooperation levels. Nitrous oxide sedation offers a valuable adjunct for managing anxiety and enhancing patient comfort. Pharmacological sedation, while efficient in certain cases, should be used judiciously due to associated risks.
Comparative Study of Mini-implants versus Standard Implants in Orthodontic Anchorage for Space Closure
Authors: Sahoo Sanjay Kumar , Chekka Manjunath , Chawla Riddhi , Naimatullah Mohammed Nehal , Misra K. Kumar , Kandikatla Pradeep , Prashant M. C.
Published: August 2024

ABSTRACT

Background:

In order to obtain satisfactory treatment outcomes, orthodontic space closure frequently requires trustworthy anchoring devices. Because they are easier to install and smaller than regular implants, mini-implants have become a viable option. The purpose of this study was to evaluate the effectiveness of regular implants versus mini-implants as orthodontic anchoring devices for closing gaps in a tertiary care context.

Methods:

A total of 100 patients who needed space closure were split into two groups at random and given regular implants (group B, n = 50) or mini-implants (group A, n = 50). The rate of space closure, anchoring loss, and patient pain were measured using visual analog scales as the primary end measures. Resonance frequency analysis was used to assess implant stability. Based on implant survival and the lack of peri-implant problems, success rates were calculated.

Findings:

Mini-implants showed much lower rates of patient pain (P < 0.001) and anchoring loss (P < 0.05) than normal implants; however, they did show comparable rates of space closure (P = 0.42). In addition, mini-implants had comparable success rates (P = 0.78) and greater implant stability (P < 0.01) when compared to normal implants.

Conclusion:

In conclusion, mini-implants have benefits in anchorage preservation, patient comfort, and implant stability over regular implants when used as orthodontic anchoring devices for space closure. They also offer equivalent effectiveness. These results provide credence to the use of mini-implants as practical substitutes in orthodontic practice.
Analysis of the Effects of Different Orthodontic Appliances on Salivary pH Levels: An In vitro Approach
Authors: Alam Mohammad K. , Hajeer Mohammad Y. , Alfuhigi Mashael Z. , Alrubaysh Mohammed A. , Alsabilah Abdulmajeed F. , Alslai Moath A.
Published: August 2024

ABSTRACT

Background:

Orthodontic appliances can influence the oral environment, including salivary pH levels, which play a crucial role in maintaining oral health. Understanding how different orthodontic appliances affect salivary pH levels can help in improving treatment outcomes and minimizing potential side effects.

Materials and Methods:

In this in vitro study, we evaluated the effects of various orthodontic appliances on salivary pH levels using a simulated oral environment. Four different types of orthodontic appliances were tested: traditional metal braces, ceramic braces, lingual braces, and clear aligners. Saliva samples were collected and subjected to pH measurements using a standardized method. The pH measurements were recorded at three different time intervals: immediately after appliance placement, after 24 hours, and after 48 hours.

Results:

The initial pH values varied among the different orthodontic appliances: metal braces (pH 7.2), ceramic braces (pH 7.4), lingual braces (pH 7.1), and clear aligners (pH 7.5). After 24 hours, there was a decrease in pH levels for all groups: metal braces (pH 6.8), ceramic braces (pH 7.0), lingual braces (pH 6.7), and clear aligners (pH 7.2). After 48 hours, the pH levels continued to decrease: metal braces (pH 6.5), ceramic braces (pH 6.8), lingual braces (pH 6.4), and clear aligners (pH 6.9).

Conclusion:

Our findings suggest that different orthodontic appliances have varying effects on salivary pH levels. Metal braces and lingual braces tend to cause a more pronounced decrease in salivary pH compared to ceramic braces and clear aligners. Monitoring salivary pH levels during orthodontic treatment may be beneficial in identifying potential risks to oral health and implementing appropriate interventions.
Early Diagnosis of Neonatal Sepsis Using Hematological Profiles
Authors: Patil Nanda J. , Tuli Shreya , Kanetkar Sujata R. , Mishra Shefali , Saad Khaled
Published: August 2024

ABSTRACT

Preterm and extremely low-birth-weight newborns are at a higher risk for early-onset neonatal sepsis (NN-SP). This condition is often linked to intrapartum fever, PROM, and sepsis occurring within the first day of life. The causal pathogen can be acquired through intrauterine transmission or from the mother’s flora. Therefore, our study aimed to evaluate PC and PI in cases involving NN-SP. Therefore, we can conclude that analyzing the PC and its indices can improve the prognosis of sepsis in NN. Studying NN using this method is a cost-effective approach that helps prevent mortality and morbidity. Early identification of newborn sepsis can help reduce the associated medical tests and medical bills. Clinical correlation with specific indicators and tools is a method for achieving this.
Genetic Characterization of Extended-Spectrum Beta-Lactamase (ESBL) and Metallo-Beta-Lactamase (MBL) Producing Klebsiella pneumoniae from Diabetic Foot Ulcer (DFU)
Authors: Kale Dipak S. , Karande Geeta S. , Kale Kalpana D. , Patil Satish R. , Datkhile Kailas D.
Published: August 2024

ABSTRACT

Background:

Antibiotic resistance in common pathogenic bacteria is linked with the genetic makeup. The genetic basis of antibiotic resistance may vary in different species or pathophysiological conditions.

Objectives:

We studied the antibiotic resistance in Klebsiella pneumonia isolates from DFU in the western Indian population. We also studied the presence of ESBL and MBL mechanisms of antibiotic resistance along with the prevalence of the genes involved in ESBL (TEM
ESBL
, SHV
ESBL
, and CTX-M
ESBL
) and MBL (NDM-1
bla
, KPC
bla
, OXA-48
bla
, and VIM
bla
) production.

Results:

A total of 161 K. pneumoniae isolates were analyzed; among which 50.93% were positive for ESBL and 45.96% were positive for MBL production. Most of the isolates were resistant to antibiotics used in the present study and partially resistant to Imipenem and Amikacin. There was no relation between the antibiotic resistance of the isolates and the production of ESBL or MBL mechanism of antibiotic resistance. Further, TEM
ESBL
was the most prevalent gene in K. pneumoniae isolates followed by CTX-M
ESBL
, NDM-1
bla
, SHV
ESBL
, and KPC
bla
. VIM
bla
was the least prevalent gene found in K. pneumoniae isolates. There was no difference in the prevalence of the genes with respect to the presence or absence of ESBL and MBL mechanism of resistance. Further, there was no relation between the prevalence of the genes and antibiotic resistance in K. pneumoniae isolates.

Conclusion:

These results along with the literature review suggest that the prevalence of the genes involved in antibiotic resistance mechanisms are widespread in India and their distribution varies in different studies.
Feracrylum—An Unexplored Aspect of Local Drug Delivery in Treating Chronic Periodontitis: An Original Research
Authors: Janardhan Karthika , Parikh Hiral
Published: August 2024

ABSTRACT

Background:

Targeted and efficient therapy strategies are necessary to address the global threat that chronic periodontitis poses to oral health. Antibiotic resistance is one drawback of traditional methods like scaling and root planing in conjunction with systemic antibiotics.

Techniques:

A study with 120 people who had been diagnosed with chronic periodontitis was done using randomized controlled trials. The subjects were grouped as the Feracrylum group and the placebo group. Clinical measures were measured at baseline and again after 12 weeks. These parameters included gingival index, clinical attachment level, and “probing pocket depth (PD).” A 3% solution was locally applied to periodontal pockets in the Feracrylum group, whereas a saline solution was given to the placebo group.

Findings:

As compared with other cohorts, the Feracrylum group showed a substantial improvement in clinical attachment level and a significant decrease in PD (P < 0.05). Although not statistically significant, the gingival index reduction in the Feracrylum group showed a tendency in the direction of better gingival health.

Conclusion:

In summary, feracrylum has the potential as a localized medication delivery adjunct for chronic periodontitis, leading to positive clinical results. Larger sample numbers and longer follow-up times are required for future studies to confirm these results and maximize the use of feracrylum in periodontal treatment.
Characterization of Lemongrass Extract (Cymbopagon citratus) Nanoemulsion and Its Application as an Antibiofilm Agent in Acrylic Resin
Authors: Sugiaman Vinna K. , Saputri Rosalina I. , Naliani Silvia , Wibisono Jane A. V. , Jeffrey  , Demolsky Wayan L. , Widowati Wahyu , Novianto Agung
Published: August 2024

ABSTRACT

Background:

An antimicrobial agent is needed for denture cleaning, such as lemongrass (LG), which has a bioactive antimicrobial component.

Methods:

This research analyzed LG extract nanoparticles with a particle size analyzer, ZPA, and biofilm formation inhibition on resin acrylic surfaces.

Results:

We found that there is high stability in nanoparticle size, while other concentrations, including chlorhexidine as a positive control, did not show any statistical differences.

Conclusion:

Lemongrass oil nanoemulsion has proved to be an antibiofilm and effective as a denture cleaning agent because of its ability to inhibit Streptococcus mutans and Candida albicans growth.
Longitudinal Analysis of Risk Factors and Outcomes in Patients with Atrial Fibrillation: Stroke and Bleeding Events
Authors: Gandhi Nayan Manish , Patel Ishan , Shukla Krutarth , Gami Nihar
Published: August 2024

ABSTRACT

Background:

“Atrial fibrillation (AF)” is a prevalent cardiac arrhythmia connected with augmented risk of stroke and bleeding events. Despite advancements in treatment strategies, managing AF remains challenging due to its multifactorial nature.

Objective:

This longitudinal research aimed to assess the risk factors and outcomes in subjects with AF over a specified period, focusing on stroke and bleeding events.

Methods:

Electronic health records of AF subjects were analyzed over a defined research period. Demographic information, comorbidities, medication history, and laboratory parameters were extracted. Stroke and bleeding events were identified, and statistical analyses were performed.

Results:

The research cohort comprised 800 AF subjects with a mean follow-up duration of 3 years. Significant risk factors for stroke and bleeding events included advancing age, hypertension, and anticoagulant use. The incidence of stroke and bleeding events augmented over the follow-up period, with notable differences in rates between patient subgroups.

Conclusion:

This longitudinal analysis provides valuable insights into the risk factors and outcomes connected with AF, particularly stroke and bleeding events. The findings underscore the importance of proactive management strategies and personalized care approaches to optimize patient outcomes in AF.
Effect of Orthodontic Treatment on Endodontically Treated Teeth
Authors: Devi Arti , Rao Srerama J. , Kedia Esha , Grover Sheetal , Das Debojyoti , Sachdeva Harmeet S.
Published: August 2024

ABSTRACT

Background:

This research has been conducted to assess the effect of orthodontic treatment on endodontically treated tooth.

Materials and Methods:

Overall, fifty subjects had been recruited. The participants received root canal therapy within 3 months as well as had an appointment for fixed orthodontic therapy. All candidates underwent an intraoral investigation. Radiographic evaluation as well as therapy planning were completed. Fixed orthodontic therapy had been initiated. All of the participants had been recalled. Endodontically restored teeth had been evaluated. All outcomes were assessed via Statistical Package for the Social Sciences (SPSS) software.

Results:

In this study, there were 25 males and 25 females. Pulp stones were seen in 15 subjects. Apical periodontitis was seen in nine subjects. Apical root resorption was seen in seven subjects, and enamel decalcification was seen in four subjects. Overall, 35 out of 50 subjects showed negative effects of orthodontic treatment on endodontically treated teeth.

Conclusion:

Excessive orthodontic force may result in increased pulp and peri-apical inflammation.
A Prospective Clinical Study Investigating the Relationship between Periodontal Disease and the Progression of Chronic Kidney Disease in Renal Transplant Recipients
Authors: Priya Pallavi , Raina Sakshi , Pathak Manisha , Kumar Subhash , Chhabra Parul , Raaj Vaibhava , Bagde Hiroj
Published: August 2024

ABSTRACT

Background:

Periodontal disease and chronic kidney disease (CKD) are both prevalent conditions with significant implications for public health. This prospective clinical study aimed to explore the potential relationship between periodontal disease and the progression of CKD in renal transplant recipients.

Materials and Methods:

A total of 150 renal transplant recipients with varying degrees of periodontal disease were enrolled in this study. Baseline periodontal assessments, including probing depth, clinical attachment loss, and bleeding on probing, were conducted. The estimated glomerular filtration rate (eGFR) was measured at baseline and followed up at regular intervals over 24 months. Participants were divided into groups based on the severity of periodontal disease for comparative analysis.

Results:

At baseline, the mean eGFR was 60.5 ± 10.2 mL/min/1.73 m2 in the mild periodontal disease group, 58.3 ± 9.8 mL/min/1.73 m2 in the moderate periodontal disease group, and 55.7 ± 8.5 mL/min/1.73 m2 in the severe periodontal disease group. Over the 24-month follow-up period, participants with severe periodontal disease experienced a significant decline in eGFR compared to those with mild or moderate periodontal disease (P < 0.05). In addition, individuals with severe periodontal disease exhibited a higher incidence of CKD progression, defined as a decline in eGFR greater than 10% from baseline.

Conclusion:

This prospective clinical study suggests a potential association between severe periodontal disease and the progression of CKD in renal transplant recipients.
Effectiveness of Brassica juncea (Mustard) Plaster on Reduction of Knee Pain and Inability among Geriatrics with Osteoarthritis
Authors: Priya D Padma , Preetha S
Published: August 2024

ABSTRACT

Pre-experimental one-group pretest posttest research design was adopted to investigate the effectiveness of Brassica juncea (mustard) plaster on reduction of knee pain and inability among 60 geriatrics with osteoarthritis. The inability was assessed using the Western Ontario McMaster University (WOMAC) Index, which includes 24 parameters under three major headings: joint pain, joint stiffness, and difficulty in performing daily activities, and the severity of pain level was assessed using a numerical pain rating scale. Mustard plaster is applied against the knee for 15 minutes once a day for seven days. On day 8, study participants were re-assessed using the WOMAC Osteoarthritis Index in the interventional group. The pretest mean score of pain was 77.80 ± 5.65, and the posttest mean score was 38.88 ± 11.76. The mean difference score was 38.92. The calculated paired ‘t’ test value of t = 24.428 was statistically significant at P < 0.001 level.
Impact of Mindfulness through Smartphone Applications on the Anxiety among B.Sc. Nursing Students
Authors: Priyadarsini A , Sangavi H , Jagadeeswari J , Cecyli C , Dayana BAA
Published: August 2024

ABSTRACT

Smartphone addiction among undergraduate students has become a pressing concern due to its association with perceived stress levels and negative impacts on their well-being and academic performance. Quasi-experimental design with nonequivalent control group samples was 100 students. Mindfulness training by using the smartphone application in four meetings for four weeks, whereas the control group was given mindfulness training after the study in the eight weeks. Anxiety is measured by the Zung Self-Rating Anxiety Scale instrument. Data were analyzed by using Mann–Whitney and Wilcoxon tests. The study found that anxiety levels decreased after mindfulness training while in the control group, anxiety increased at posttest, indicating a significant difference. Mindfulness training through smartphone devices SIMBA application has a significant effect on reducing anxiety levels in third-year nursing students. These findings demonstrate the necessity of educating students about the detrimental consequences of smartphone addiction on mental health, especially perceived stress and promoting the adoption of coping mechanisms.
The Study to Assess the Effectiveness of Cissus Quadrangularis among Postmenopausal Women with Osteopenia
Authors: Priya R Sindhu , Swathi R , Selvi S Tamil , Anitha D , Kavitha M , Hemavathi R , Keerthika C
Published: August 2024

ABSTRACT

Background:

Osteopenia refers to bone density that is not only normal but also not as low as that noted in osteoporosis. Osteopenia leads to osteoporosis and increases the risk of fractures. Current research is focused on agents that will prevent or slow the progression of bone loss.

The Objectives of the Study:

To assess the pretest and posttest levels of osteopenia among postmenopausal women, and to assess the effectiveness of Cissus quadrangularis (CQ) on postmenopausal women with osteopenia.

Methodology:

A true experimental study design using targeted sampling techniques was used to conduct 60 patients with osteopenia. The data were collected with the help of structured questionnaires. Confidentiality was maintained throughout the process. The data collected were analyzed using descriptive and inference statistics.

Result:

A total of 60 participants completed this study. The percent BMD changes in the CQ-treated groups did not differ at any site after 24 weeks compared to the placebo. Reduced bone remodeling activity was detected in both CQ-treated groups. These results correlated with the within-group comparison, which showed a continuously significant increase in both BTMs in the placebo group.

Conclusion:

This is the first clinical report that showed a promising effect on delaying bone loss of oral administration of CQ for 24 weeks, as indicated by a slower bone remodeling process via a reduction in BTMs. However, no change in BMD was observed.
Impact of Mind-Body Interventions on Psychosocial and Bio Physiological Markers among Elderly
Authors: Lakshmanan Jayalakshmi , Gopalakrishnan Bhuvaneswari , Rajendran Shankar Shanmugam
Published: August 2024

ABSTRACT

Background:

The global demographic shift toward an older population is witnessing an increase in age-related psychological disorders and chronic illnesses, particularly among those residing in old age homes. Mind-body interventions (MBIs) have shown promise in enhancing mental and physical health without the adverse effects associated with pharmaceuticals.

Materials and Methods:

This quasi-experimental study involved 42 elderly participants from two old age homes in South India. Participants were divided into an experimental group, which received interventions including Benson’s Relaxation Technique, Guided Imagery, and various mindfulness exercises, and a control group, which received routine care. Assessments of stress, anxiety, depression, and quality of life were conducted at baseline and post-intervention using standardized scales.

Results:

The experimental group exhibited significant improvements, with reductions in stress scores from an average of 23.71 to 10.86, anxiety scores from 27.62 to 12.71, and depression scores from 10.05 to 5.24. The quality of life scores improved from an average of 37.81 to 54.24. In contrast, the control group showed minimal changes in these psychological parameters, with only slight modifications in quality of life scores from 37.24 to 38.38. Physiological and biochemical markers remained largely unchanged across both groups.

Conclusion:

The study highlights the critical role of nurses in implementing MBIs to enhance the psychological health and overall well-being of the elderly. Integrating these interventions into regular nursing care can significantly improve the quality of life for elderly individuals, suggesting the adaptation of MBIs as primary non-pharmacological interventions in elderly care practices.
Dermatitis artefecta: Effectively managed with psychotherapy and counselling
Authors: Mahanta Debasish , Mohanty Nitya Gopal
Published: August 2024

A 20-year-old female presented to the psychiatry outpatient department with multiple lesions at various stages of healing over accessible parts of the body, not improving with multiple dermatological treatments over 6 months. A diagnosis of dermatitis artefacta was made. The patient effectively managed with psychotherapy and counseling with complete resolution of symptoms.
Heart rate variability and fasting plasma glucose as trait marker of psychosis: A comparative study between drug naive patients with psychosis and healthy volunteers
Authors: Samantray Swayanka , Mishra Suvendu Narayan , Jitendriya Biswal , Debadatta Mohapatra
Published: August 2024

BACKGROUND:

To date, mixed results have been obtained regarding the metabolic and cardiovascular changes in drug-naïve psychotic patients. Moreover, very few Indian studies are available on this subject. The current study adds to the Indian research on metabolic and cardiovascular factors associated with psychotic disorders.

AIM:

The aim of the study is to determine that metabolic abnormalities such as “impaired glucose tolerance, abnormal lipid profile, and cardiovascular risks are associated with the pathophysiology of the disease itself, i.e., psychosis.

MATERIALS AND METHODS:

The present study was a hospital-based cross-sectional study conducted over 2 years that included 30 drug-naïve psychotic patients as per ICD-10 DCR and 20 healthy volunteers. Purposive sampling was done. The patients and matched healthy volunteers fulfilling the inclusion and exclusion criteria were assessed to obtain the sociodemographic data, and a mental state examination was done. Positive and Negative Syndrome Scale was applied to patients only. The required investigations, such as lipid profile, sugar profile, body mass index, and electrocardiogram (ECG) for root mean square standard deviation (RMSSD) (heart rate variability [HRV]-time domain), heart rate, and corrected QT interval, were done in both the groups after obtaining written informed consent. The ECGs of all subjects in both groups were obtained mostly in the morning between 10 am and 12 am. The subjects were asked to avoid coffee and nicotine for 1 h before the ECG recording. The patient was asked to rest for 10 min before the recording and 1 min 6-lead ECG recording was obtained in a supine position at complete rest. RMSSD was calculated from the reading of lead II on 1 min resting ECG.

RESULTS:

Most of the metabolic and cardiovascular factors showed no statistically significant difference between the two groups except fasting blood sugar (FBS) (t = 0.843, P = 0.033), and median value of HRV (P = 0.008). Mean FBS was higher in the patient group compared to the control, and mean HRV was lower in the patient group compared to the control.

CONCLUSION:

The findings of the current study, in conjunction with the findings from other methodologically similar studies, suggest that lower HRV and abnormal fasting glucose may be associated with the psychopathology of psychotic illnesses.
Perfect sampling of $q$-spin systems on $\mathbb{Z}^{2}$ via weak spatial mixing
Authors: Anand Konrad , Jerrum Mark
Published: August 2024

We present a perfect marginal sampler of the unique Gibbs measure of a spin system on

\mathbb{Z}^{2}

. The algorithm is an adaptation of a previous “lazy depth-first” approach by the authors, but relaxes the requirement of strong spatial mixing to weak. Our result is a step towards methods of efficient sampling using only weak spatial mixing. The work exploits a classical result in statistical physics relating weak spatial mixing on

\mathbb{Z}^{2}

to strong spatial mixing on squares. When the spin system exhibits weak spatial mixing, the run-time of our sampler is linear in the size of sample. Applications of note are the ferromagnetic Potts model at supercritical temperatures and the ferromagnetic Ising model with consistent non-zero external field at any non-zero temperature.
Titanium Alloy, Sheet, Strip, and Plate, 6Al - 4V, Annealed
Authors:   AMS G Titanium and Refractory Metals Committee
Published: August 2024

This specification covers a titanium alloy in the form of sheet, strip, and plate up through 4.000 inches (101.60 mm), inclusive, in thickness (see 8.6).
Optical Equipment Safety in Aircraft Fuel Tanks
Authors:   AE-5A Aerospace Fuel, Inerting and Lubrication Sys Committee
Published: August 2024

The recommended practices of this document are intended for optical devices and associated optical cables and connectors installed inside transport category aircraft or environments of equivalent ignitability.

This document covers optical radiation in the wavelength range from 380 nm to 10 μm. As explained in this document, wavelengths below this range are capable of igniting fuel-air mixtures through an ignition mechanism not considered at this issue of ARP7977. Use of wavelengths outside the range 380 nm to 10 μm should be discussed with the relevant Certification Authority.
ANALISIS PERHITUNGAN PAJAK PENGHASILAN PASAL 23 DAN PAJAK PERTAMBAHAN NILAI ATAS JASA PENGANGKUTAN PADA PT. ANUGERAH KREASI SELARAS MEDAN
Authors: Andini Retno Putri , Septriawan M. Reza , Marviana Ratna Dina
Published: August 2024

The duty to pay the taxes of Anugerah Kreasi Selaras Medan pursuant to the established rate, with a reduction of the income tax of Article 23 of 2% of the tax base. (DPP). Respect for payments and reporting reflects professionalism, social responsibility, and positive contributions to economic development. Focus on the tax cuts, calculation, and reporting aspects of the Harmonized Creative Awards, related to Value Added Tax (PPN). Despite a VAT rate of 11%, the company exempts VAT on transport services under government regulations. And regardless of the purpose of this study, How the calculation, reduction, and deposition of income tax and value added tax on PT. And despite payments being delayed for several months due to falls on Sunday, the company is still showing good faith. PT Anugerah Kreasi Selaras adheres to the cut-off exemption rules for service companies with tax-free declarations.Annual evaluation shows an increase in the amount of DPP and VAT owed paid. The VAT exemption on transport services is aimed at keeping land transport tariffs affordable to the public and encouraging economic growth and job creation. The positive impact involves strengthening the public transport sector and preventing the transition of the public to other modes of transport that may occur as a result of the increase in tariffs due to the burden of VAT
ANALISIS LAPORAN KEUANGAN UNTUK MENILAI KINERJA SEBELUM DAN SAAT PANDEMI COVID-19 PADA PT ZONA PROPERTY
Authors: Istiarsih Fitri , Nursidin M. , Risuhendi Risuhendi
Published: August 2024

Companies in the property or real estate sector are starting to experience the impact of the slowdown due to the onset of the Covid-19 outbreak. In this case, it is necessary to have an assessment of financial performance by analyzing the company's financial statements in a given period. Generally, the ratio that is often used to measure the performance of a company is the liquidity ratio, the solvency ratio and the profitability ratio. The problem formula in this study is how the financial condition if measured from the liquidity ratio covers the current ratio and the cash ratio? How does the financial condition if measured from the solvency ratio include the debt to equity ratio and the Debt to asset ratio? How do financial conditions be measured from the profitability ratio to include the gross profit margin and the net profit margin? And the purpose of this research is to find out and analyze the financial performance of the Property Zone if measured by the liquidity ratio (current ratio and cash ratio), to know and analyse the financial performances of the property zone if measurable by the solvency ratio, and to learn and analyse financial performance at the Properties Zone when measuring by the profitability ratio. (gross profit margin dan net profit margin). The results of this study showed that the liquidity ratio and solvency ratio of PT Zone Property was rated very well because the total average ratio was in accordance with industry average standards.
PADAMSHIKA KRAMA: A CRITICAL EVALUATION OF TRANSITION STRATEGY
IN SUBSTANCE DEPENDENCY
Authors: Nikiben Manubhai Patel , Nagesh K A Sri
Published: August 2024

"Padamshika Krama" is a unique concept described in the Bruhatrayees for changing bad habits to good ones. It
comprises a step-by-step plan for gradually adopting good habits and avoiding bad ones. This transition from
Ahita to Hita has been designed to be smooth and maintain the body’s equilibrium. Different Acharyas have outlined various patterns of Padamshika Krama, completing the process within 7, 10, 15, 46, or 63 days.
This strategy prevents Dosha imbalance and diseases caused by incompatibility, which can occur when new habits are abruptly adopted, and old ones are discarded. Padamshika Krama applies to a variety of addictions, including opiates, caffeine, alcohol, tobacco, and cannabis. Gradually quitting these addictive substances, along with
providing replacements, helps to prevent withdrawal symptoms. The article's primary goal is to compile a review
of Padamshika Krama from Bruhatrayees and apply specific patterns of Padamshika Krama based on the severity
level of drug dependence. In parallel, Ayurvedic principles are used to select replacements to create a false sensation of addiction as well as balance Doshas.