bluuebunny/crossref_metadata_2025 huggingface dataset:
Formation of digital competence of future teachers-psychologists
Authors: Dudina O. V.
Published: October 2022

The relevance of the article is due to the changes taking place today in the world community. Today we are no longer talking about a post-industrial, but about a data-centric world in which data itself, its collection, storage and further application come out on top. Therefore, the presence of digital competence is a necessary element of human existence in the modern information space. This article analyzes the works of authors developing the problem of competence of educational workers in a digital society. The author considers the concept of digital consumption in the process of application in educational activities as one of the components of the digital competence of the future teacher-psychologist. The article highlights the results of diagnostics of the level of formation of digital consumption as a component of digital competence of the future teacher-psychologist at the ascertaining and control stages of the experiment conducted on the basis of the I.Ya. Yakovlev Chuvash State Pedagogical University. The study was conducted between October 2021 and May 2022. In the course of the study, the level of formation of digital consumption of students of the Faculty of Psychology and Pedagogy was checked. The methods of the Russian Center for Internet Technologies, the All-Russian Center for the Study of Public Opinion, and the National Agency for Financial Research were used in the process of diagnosing volunteer students. The ascertaining stage of the experiment on the formation of digital competence revealed that few students use digital technologies at a sufficient level in their activities. During the formative experiment to improve digital competence, students were taught the skills of using modern information technologies and using digital tools in their professional activities. At the control stage of the experiment on the formation of digital competence of the future teacher-psychologist, we found that the indicators of achieving digital consumption in the field of professional activity of a teacher-psychologist significantly increased after lectures and practical classes in the field of digital consumption. The article may be useful for further research in the field of digitalization of vocational education
A study of plasma folate under the influence of [6S]-5-MTHF in women with 677C→T polymorphism of mthfr with different types of inheritance
Authors: R. Prinz-Langenohl  , S. Brämswig  , O. Tobolski
Published: October 2022

Background and purpose: 5,10-Methylenetetrahydrofolate reductase is responsible for the synthesis of 5-methyltetrahydrofolate (5-MTHF). The 677C→T mutation of 5,10-Methylenetetrahydrofolate reductase reduces the activity of this enzyme. The aim of this study was, first, to compare pharmacokinetic parameters of [6S]-5-MTHF and folic acid in women with the homozygous (TT) and wild-type (CC) 677C→T mutation, and second, to explore genotype differences. The metabolism of [6S]-5-MTHF and folic acid was evaluated by measuring plasma folate derivatives.Experimental approach: Healthy females (TT, n = 16; CC, n = 8) received a single oral dose of folic acid (400 microg) and [6S]-5-MTHF (416 microg) in a randomized crossover design.Plasma folate was measured up to 8 h after supplementation. Concentration-time-profile (area under the curve of the plasma folate concentration vs. time), maximum concentration (Cmax) and time-to-reach-maximum (tmax) were calculated.Key results: Area under the curve of the plasma folate concentration vs. time and Cmax were significantly higher, and tmax significantly shorter for [6S]-5-MTHF compared with folic acid in both genotypes. A significant difference between the genotypes was observed for tmax after folic acid only (p < 0.05). Plasma folate consisted essentially of 5-MTHF irrespective of the folate form given. Unmetabolized folic acid in plasma occurs regularly following folic acid supplementation, but rarely with [6S]-5-MTHF.Conclusions and implications: These data suggest that [6S]-5-MTHF increases plasma folate more effectively than folic acid irrespective of the 677C→T mutation of the 5,10-Methylenetetrahydrofolate reductase. This natural form of folate could be an alternative to folic acid supplementation or fortification.
Herbicide mixtures for post-emergence control of horseweed in coffee interrow
Authors: Bornelli Breno Ribeiro , Ferreira Chayenne de Lira , Ferreira Carlos Henrique de Sousa , Carvalho Saul Jorge Pinto de
Published: October 2022

Glyphosate-resistant biotypes of horseweed (Conyza spp.) have been a constant problematic for coffee growers all over Brazil. Therefore, this work was developed with the objective of evaluating efficacy of different herbicides, applied isolated or in mixture, for horseweed control in coffee plantation interrows.  A field trial was performed with the following treatments (g ha-1): glyphosate at 925, glufosinate-ammonium (GA) at 500, saflufenacil at 49, flumioxazin at 50, glyphosate + GA (925 + 500), glyphosate + saflufenacil (925 + 49), glyphosate + flumioxazin (925 + 50), GA + saflufenacil (500 + 49), GA + flumioxazin (500 + 50) and glyphosate + saflufenacil + clethodim (925 + 49 + 108), besides check plots without herbicide application.  The treatment with clethodim was included considering a possible concomitant presence of sourgrass (Digitaria insularis (L) Fedde) in the areas.  At the moment of herbicide application, horseweed was 40 cm tall in pre-flowering.  Percent control was evaluated at 7, 14, 21 and 28 days after application (DAA), as well as mass of dry matter at 28 DAA.  In general, adequate control of horseweed was obtained with glufosinate-ammonium applications, isolated or in mixture with glyphosate, saflufenacil or flumioxazin. Mixture of glyphosate and saflufenacil has also reached high control of horseweed infestation, without difference to GA treatments.  As conclusion, horseweed infestations in coffee interrow may be efficiently controlled with tank mixtures of herbicide.
Comparison of nonlinear models for the description of carbon mineralization in degraded pasture soil and in soils with plant cover
Authors: Vilela Marina de Souza Leonel , Silva Edilson Marcelino , Fruhauf Ariana Campos , Silva Édipo Menezes da , Muniz Joel Augusto , Fernandes Tales Jesus
Published: October 2022

Tree planting is an important way to restore degraded areas, however, the quality of the plant residue added to the soil influences the organic matter decomposition rate and, consequently, carbon availability. Carbon mineralization curves over time make it possible to understand the decomposition of organic residues and improve soil management. Nonlinear regression models have been used to describe the dynamics of carbon mineralization over time, as they summarize the information contained in the data in just a few parameters with practical interpretations. Thus, this study aimed at evaluating the nonlinear models Cabrera, Juma and Stanford & Smith to describe the soil carbon mineralization in the following plantations: Secondary forest, Acacia auriculiformis, Mimosa caesalpiniifolia and Pasture, obtained from the first to the twentieth week. All the computational part involved in the adjustments and analyses was performed using the R statistical software. The most suitable regression model was selected for the description of soil carbon mineralization for each vegetation cover based on the following criteria: adjusted coefficient of determination (R2adj), residual standard deviation (RSD) and Akaike information criterion (AIC). For Acacia, the Cabrera model was indicated as the best to describe this treatment. For Forest and Pasture, the Juma model had the best fit, and the Stanford & Smith model best described the Mimosa treatment.
Social wasps (Vespidae, Polistinae) in a Cerrado agrosystem in the state of Minas Gerais, southeastern Brazil
Authors: Dutra Barbosa Leonardo , De Castro Jacques Gabriel , Magalhães de Souza Marcos
Published: October 2022

The survey and identification of social wasps, mainly in predominantly agricultural environments, is the first step to identify the ideal species to be used in biological pest control programs. The present work aims to inventory the social wasp fauna in an agrosystem in the Cerrado, Minas Gerais and identify species with potential to be used in biological control. Through active search, 478 wasps of 8 genera and 17 species were collected. The dominance of some species such as Protopolybia sedula, Polybia ignobilis, Polybia paulista, Polybia fastidiosuscula and Polybia occidentalis reinforces the importance of these species in agricultural environments and their potential use in biological pest control. In addition, this work confirms that some species of social wasps benefit from the anthropized environment, such as Polistes versicolor, which uses human constructions for nesting.
Social and cultural practices as a means of self-actualization of students of the supplementary education institutions
Authors:   Ilya Ulyanov State Pedagogical University, Shustova Lyubov P. , Danilov Sergey V. ,   Ilya Ulyanov State Pedagogical University, Bodina Natalya S. ,   Regional Model Center for Additional Education for Children of the Ulyanovsk Region, Chenakina Anna G. ,   Children’s and Youth Center No. 3
Published: October 2022

The relevance of the work is determined by the insufficient previous study of the influence of socio-cultural practices on the selfactualization of students of the supplementary education institutions. The purpose of the research is to study the influence of socio-cultural practices on the self-actualization of students of the supplementary education institutions. Hypothesis: participation of students in sociocultural practices will contribute to their self-actualization. The study sample was formed by adolescents aged 12–18. The experimental sample (n = 109) is represented by the students of DUC (Children-Adolescents Center) No. 3, the control one (n = 98) is formed by the students of SOSH (secondary school) No. 27, CDT (Center of Children’s Creative Work) No. 4, CRTDIU (Center of Children’s and Youth’s Creativity Development) named after A. Matrosov in Ulyanovsk. To study self-actualization, the following methods were used: the questionnaire “Success Motivation and Fear of Failure” by A. A. Rean, the Personal Orientation Inventory by E. Shostrom (adapted by A. Jones and R. Crandall). It has been found out that the use of socio-cultural practices in the supplementary education institutions leads to a noticeable increase in motivation for success and a decrease in motivation for avoiding failures among adolescents, and also to an increase in the number of students with a high level of self-actualization. Simultaneously, an increase in these indicators was also observed in the control group, but it was less significant. This is manifested in an increase in the number of winners and prize-winners of competitions, exhibitions, Olympiads among children who have been actively participating in socio-cultural practices for a long time. The authors make a conclusion about the positive impact of socio-cultural practices on the adolescents’ motivation and self-actualization. This experience can be recommended for use in schools and supplementary education institutions.
Professional self-development of future domestic science teachers as a relevant problem in the process of their training
Authors:   Saratov State University, Sayapin Nikolay V.
Published: October 2022

The problem of professional self-development of future domestic science teachers in the process of their training is relevant due to the fact that modern educational institutions need teachers who are able to quickly adapt to sweeping changes and are able to develop independently in the professional field. University training of future domestic science teachers is one of the stages of their professional self-development. The objective of the study is to determine to what extent university training of future domestic science teachers is important for their professional self-development. The objective is achieved through the analysis of regulatory documents, the analysis of scientific research and the results of student questionnaires. The presence or absence of aspects affecting the professional self-development of future domestic science teachers were determined while conducting the analysis of the federal regulatory documents that govern the training process of future domestic science teachers at the university. The analysis was carried out in accordance with the Federal State Educational Standard of Higher Education and the “Teacher” Professional Standard. The Federal State Educational Standard for Bachelor’s and Master’s degrees includes a directive to develop a competence closely related to the professional development of future domestic science teachers – Universal Competence-6 (UC-6). The analysis of the professional standard of a teacher allows us to distinguish two fundamental roles teachers perform at work. These roles indicate those actions, skills and knowledge that are collectively associated with the professional self-development of teachers. The empirical research was carried out on a sample of students (N = 52, aged 18 to 30 years, women = 60%), majoring in pedagogy (44.03.01 Pedagogical Education with the major in “Domestic Science”) at Saratov State University (the city of Saratov). A questionnaire (prepared by N. V. Sayapin) was used to determine to what extent professional self-development is significant. The posi tive dynamics of the parameters of time spent on professional self-development for senior courses has been revealed. There is a consensus among respondents that professional self-development is an integral component of professional growth and part of competitiveness in the profession. The presented empirical materials can be used in creating pedagogical conditions for the implementation of effective training aimed at professional self-development of students.
Results of the scientific dialogue: Problems of psychological services development and functioning in the system of professional education
Authors:   Psychological Support Center of Saratov State Law Academy, Klenova Milena A. , Yakovleva Kseniya A. ,   Psychological Support Center of Saratov State Law Academy, Lyubakova Alina K. ,   Saratov State University
Published: October 2022

The article presents the results of the interregional round table with international participants “Problems of Psychological Services Development and Functioning in the System of Professional Education”. The round table was organized by Saratov State Law Academy, the Center of Psychological Support of Saratov State Law Academy, on the one hand, and the Institute of Youth, the Institute of Psychoanalysis and the Philosophy Department of the State Academic University for the Humanities, on the other hand. The paper shows the results of the round table meeting and master classes. It indicates the problems of the psychological services formation and their functioning in the system of professional education. Moreover, the article presents the urgent tasks of psychological services in the system of professional education. The results of the round table are summarized.
Class teacher and student group curator: Updating the training strategy and methodology: All-Russian scientific and practical conference
Authors:   Novosibirsk State Pedagogical University, Romm Tatyana A.
Published: October 2022

The article provides information about the upcoming on October 25–27, 2022 All-Russian scientific and practical conference with international participation “Class Teacher and Student Group Curator: Updating the Training Strategy and Methodology”. The purpose of the conference is to determine the specifics and methods of training class teachers and student group curators, to generalize advanced pedagogical experience, scientific and methodological support in the course of training class teachers and student group curators. The conference will be held on the basis of Novosibirsk State Pedagogical University.
Nieznośna lekkość realnego – próba lacanowskiej (para-)ontologii
Authors: Michalik Grzegorz
Published: October 2022

Realne stanowi jeden z najciekawszych i zarazem najbardziej „filozoficznych” konceptów Lacana. I choć odkrycie Realnego wiąże się przede wszystkim z kliniką, to nie można zaprzeczyć, że teoria trzech rejestrów niesie ze sobą implikacje niemal metafizyczne. W niniejszym artykule autor opisuje rozwój pojęcia Realnego w nauczaniu Lacana, próbując jednocześnie odpowiedzieć na pytanie o możliwość psychoanalitycznej (para-)ontologii. Okazuje się, ze tym, co wyróżnia lacanowski realizm jest specyficzny ruch – od transcendencji do immanencji.
​Avian Diversity in Agricultural Mosaics in District Ludhiana, Punjab, India
Authors: Thind Sandeep Kaur , Kumar Charn , Kaleka Amritpal Singh
Published: October 2022

Background: The birds constitute one of the most popular and easily recognizable groups of animals. They constitute the largest class of terrestrial chordates. The present paper deals with the documentation of number of avian species from agricultural mosaics in Ludhiana district of Punjab along with their residential and IUCN status 2020. Methods: During the present study, periodic monthly as well as random surveys were conducted to document various bird species occurring in the study area from May 2016 to April 2019. The study area was categorized into agricultural, aquatic and forest habitats. Result: A total of 173 species of birds referable to 17 orders and 56 families have been documented from the study area and identified on the basis of various morphological features and calls. During this study, maximum number of species have been recorded from agricultural habitat (118 species), followed by aquatic habitat (114 species) and the area covering the forest habitat and roadside plantations (71 species). However, some species have been found as common in these habitats.
​Effect of Hoof Trimming Intervention on Milk Yield and Composition in Dairy Lame Cows
Authors: Saikiran Jettaboina , Prasanna S.B. , Gouri Mahadevappa D. , Kumar G. Mahesh , Umashankar B.C. , Kumar G.K. Anil , Nagesh A.M. , Patil Vivek M.
Published: October 2022

Background: Hoof lesions and lameness in cattle is currently a serious problem in the dairy industry and significantly affects the health and welfare of animals. High milk yield has been associated with lameness and claw lesions. It was found that 87.5% of lame animals were suffered from claw lesions and hoof lesions were present in all the cows having lameness. Hoof trimming is performed to prevent hoof lesions and improve gait by correction and maintenance of the hoof symmetry and shape. Lameness caused by hoof disorders can be treated by correct hoof trimming. The aim of this study was to know the production performance in dairy cattle before and after hoof trimming. Methods: In this study twenty lame cows were selected and lameness index score was given to them (0-5 score). The nutrient requirements of the animals were met as per ICAR (2013) through concentrate feed and ad libitum green fodder. Care was taken to ensure that feed was provided at same levels throughout the study period and to nullify any effects of feed on lameness. Milk yield in kg/day were recorded before week of hoof trimming (HT) and after hoof trimming intervention it was recorded on 0th day, 3rd day, 6th day, 8th day, 11th day, 14th day. Result: Our results showed that significant difference (P≤0.05) in milk yield was on 0th day, 3rd day, 6th day and 8th day when compared with before week of HT (13.25±0.83). Significant increase in milk Fat % (P≤0.05) was observed on 11th day and 14th day (4.10±0.04), significant decrease (P≤0.05) in milk SNF % was observed on 0th day, 3rd day, 6th day and 8th day (8.45±0.03), whereas significant difference (P≤0.05) in milk protein % was observed on 0, 3 and 6th day (2.64±0.04) when compared with before week of HT. From this study it was concluded that the hoof trimming intervention has an immediate effect on production performance of dairy cows. Further this is a novel improved intervention using angle cutter modified to trim the hoof which is safe and painless compared to conventional Hoof cutter which caused a lot of cutting and bleeding hooves.
Effect of Lactation on Haematological and Metabolic Profile in Zobawng Cattle
Authors: Das Hemen , Ali M. Ayub , Doley Probal Jyoti , Das Biren Kumar , Newmai Kekungwi , Debnath Ashmita , Azyu R. Zapaw
Published: October 2022

Background: Zobawng is a local non-descript cattle of Mizoram, a hilly state of North-east India.Current study was carried out to investigate the haemato-biochemical profile of Zobawng cattle with the purpose of analyzing the physiological variations under the influence of different lactation stages in terms of determining possible biomarkers to monitor the energy balance and the metabolic adequacy during lactation. Methods: Eighteen clinically healthy lactating Zobawng cattle were categorized into three groups based on the length of their lactation: group-I (early stage), group-II (mid stage) and group-III (late stage). Haematological analysis was carried by automated blood analyzer (Melet Schlosing4e, France); whereas, metabolic parameters were evaluated by using automated clinical chemistry analyzer (Fuji Dry Chem 4000i, Fujifilm, Tokyo, Japan). Result: Haematological parameters varied non-significantly amongst the three groups of animals. The value of packed cell volume (PCV), RBC count and haemoglobin (Hb) concentration were found to be lowest during early stage of lactation. Other parameters viz. total leucocyte count (TLC), differential leucocyte count (DLC), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and platelet count were within the normal limits. Similarly, metabolic parameters also differed apparently, but the differences were statistically non significant amongst the groups. The glucose level was recorded to be the lowest in the early stage of lactation; whereas, protein and creatinine concentrations were slightly higher in this stage. No significant alteration in the concentration of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) was noticed amongst the three groups of cattle. Data generated during the study may be useful as reference values for the scientific community as this is the first study of its kind in Zobawng cattle.
Molecular Characterisation of Cryptosporidium parvum among Cattle and Cattle Handlers from Tripura (India) and the Associated Risk Factors
Authors: Das Prasenjit , Deka Devajani , Lalrinkima H.
Published: October 2022

Background: Cryptosporidium parvum is major protozoan parasite of both animals and humans with zoonotic significance. There is a paucity of information on its occurrence and associated risk factors in North Eastern states, India. The present study aimed at the molecular characterization of Cryptosporidium from cattle and cattle handlers in West district of Tripura and risk associates analysis. Methods: Faecal samples were randomly collected from cattle and cattle handlers (100 each), of West district, Tripura. The samples were subjected to sheather’s sucrose flotation, modified Zeihl Neelsen (mZN) staining and PCR assay targeting the 18S SSUr-RNA gene for detection of Cryptosporidium. The polemerised chain reaction- Restriction length polymorphism (PCR-RFLP) was done to detect Cryptosporidium spp. and C. parvum genotypes. Association of the epidemiological variables in relation to host and environment were studied for comparative analysis. Result: The incidence of Cryptosporidium was 16 per cent and 7 per cent in cattle and cattle handlers, respectively. The molecular characterisation based on PCR-RFLP analysis revealed 14 C. parvum and two C. andersoni and three C. parvum in cattle handlers. All the 14 C. parvum from cattle and one C. parvum from cattle handlers belonged to bovine genotype (genotype II) and other two C. parvum from cattle handlers belonged to the human genotype (genotype I). Cryptosporidiosis in both cattle and cattle handlers were strongly associated with younger age group and diarrhoeic faecal consistency with significantly (p less than 0.01) higher occurrence. However, significantly (p less than 0.05) higher predominance of monsoon season in occurrence of the disease was observed in cattle and sex predominance was not observed in both cattle and cattle handlers.
Diseño y construcción de sistema de muebles inteligentes para ayudar a conciliar el sueño
Authors: Gómez-Leitón Andrés , Guzmán-Reuben Hermann , Leiva-Mata Moisés , Morera-Solís Marco
Published: October 2022

El proyecto consistió en desarrollar un sistema de muebles que buscaban facilitar la conciliación del sueño en la población joven adulta en Costa Rica. A partir del problema y requerimientos, previamente planteados; se desarrolló una investigación para determinar las causas del problema y una serie de posibles soluciones que fueran de la mano con la tecnología. Luego se plantearon posibles conceptos tomando en cuenta todos los resultados de la investigación para desarrollar una serie de propuestas por concepto y luego gracias a los requerimientos previos se seleccionó una propuesta que cumpliera con cada uno de estos más uno requisito formal. En el cual se tuvo en cuenta la simpleza, adaptabilidad, factibilidad constructiva y apego del diseño al problema a solucionar. De esa manera se depuró por la mejor solución la cual fue construida para una posible validación posterior.
Assessement of the heavy metal contamination of soils in Kondopoga and Kostomuksha (Republic of Karelia)
Authors: Novikov S. G.
Published: October 2022

Surveys were carried out in Kondopoga and Kostomuksha, where the main industries are pulp-and-paper making and iron ore mining and concentration, respectively. Samples were taken from the top 0–10 cm soil layer in sites belonging to different land use categories and the content of heavy metals (Pb, Cu, Zn, Ni, Co, Cr, Mn) in the samples was determined by atomic absorption spectrophotometry (Aqua Regia extract). In addition, subsidiary soil pits were made for sampling at 0–5, 5–10, and 10–20 cm depths. These samples were analyzed for physico-chemical properties and heavy metal content. The results showed a relatively low level of heavy metal pollution of soil in the mentioned towns. Surveys in Kondopoga revealed limited general-use areas containing some elements in concentrations exceeding Russian national maximum allowable (MAC) and tentative allowable (TAC) levels (Pb – 6x MAC, Cu – 9x TAC, Zn – 16x TAC), and with labile copper and zinc concentrations up to 2x–3x MAC. Soils of Kostomuksha exhibited relatively low levels of the analyzed heavy metals with concentrations generally not exceeding the regional background in all land use categories. It was only occasionally that pollutant concentrations (Pb, Ni, Cu, Zn) reached 1–2x MAC/TAC. The resultant data can be used in the monitoring of urban soils and for working out recommendations for environmental protection.
Recognition of arable soils from photographs obtained as part of crowdsourcing technologies
Authors: Prudnikova E. Yu. , Savin I. Yu. , Vindeker G. V.
Published: October 2022

The study focuses on the possibilities of using photographs obtained using crowdsourcing technologies for the operational inventory of arable soils. The object of the study is the spectral reflectance of the open surface of arable soils of the test plots, measured using a HandHeld-2 spectroradiometer operating in the range of 325–1 075 nm, and their image in photographs taken with conventional cameras. Test sites are located in the Tula, Moscow and Tver regions. The soils of the test plots are sod-podzolic, gray forest, and leached chernozems. Based on the analysis of photographs of the surface and information obtained using a spectroradiometer, a set of spectral parameters in the RGB, YMC and HSI color systems, as well as their ratios (45 parameters), was calculated. These parameters were used to separate the analyzed soil types using classification trees. The accuracy of classification based on the results of validation varies from 63–100%. At the same time, the parameters of the HSI and YMC color systems turned out to be more informative than the parameters of the RGB color system. The established classification rules can later be used to determine the classification position of soils from images collected using crowdsourcing technologies.
A Exposição ao Chumbo na Base de um Quadro de Arritmias Cardíacas
Authors: Coelho Margarida , Abreu Diogo , Silva Laura , Pereira Miguel , Mautempo Fernando
Published: October 2022

A reciclagem de baterias usadas tem suscitado preocupações de saúde pública uma vez que esta atividade está associada à exposição ocupacional e ambiental ao chumbo. Descreve-se o caso de uma mulher de 26 anos que iniciou quadro de palpitações associado a cefaleias, fadiga e insónias, cerca de quatro meses após iniciar funções numa empresa de reciclagem de baterias. Analiticamente, observou-se anemia (Hb 11,9 g/dL) e plumbémia de 59 μg/dL. Cessou funções na empresa e, após um mês, referiu uma diminuição progressiva da sintomatologia. O estudo analítico revelou uma normalização dos valores da hemoglobina (12,2 g/dL) e uma diminuição do valor de chumbo no sangue para 23,4 μg/dL. Os efeitos na saúde da exposição ao chumbo são inespecíficos e o seu diagnóstico requer um alto grau de suspeição. Neste âmbito revela-se importante a articulação entre o médico assistente e os serviços de Saúde, Higiene e Segurança no Trabalho das empresas.
Collagen synthesis in the skin: genetic and epigenetic aspects
Authors: Potekaev N. N. , Borzykh O. B. , Shnayder N. A. , Petrova M. M. , Karpova E. I. , Nasyrova R. F.
Published: October 2022

One of the most important functions of the skin, mechanical, is provided by collagen fibers and their interaction with other elements of the extracellular matrix. Synthesis of collagen fibers is a complex multistep process. At each stage, disturbances may occur, leading, as a result, to a decrease in the mechanical properties of the connective tissue. In clinical practice, disorders of collagen synthesis are manifested through increased skin laxity and looseness and premature aging. In addition to the clinical presentation, it is important for the cosmetologist and dermatologist to understand the etiology and pathogenesis of collagenopathies. The present review summarizes and systematizes available information about the role of genetic and epigenetic factors in the synthesis of collagen fibers in the skin. Understanding the etiology of collagen synthesis disorders can allow doctors to prescribe pathogenetically grounded treatment with the most effective results and minimize adverse reactions.
Features of the attitude to vaccination against COVID-19 in Russia
Authors: Galkin S. A. , Naidenko D. G. , Kornetov A. N. , Goiko V. L. , Myagkov M. G.
Published: October 2022

Background. 1.5 years after the registration of the first vaccine against COVID-19 in Russia, national herd immunity reached only 49.7%. It is obvious that the success of vaccination measures depends on the readiness of the population for immunization and their attitude to the vaccine.

The aim of the study was to research the attitude to vaccination against a new coronavirus infection among various socio-demographic population groups in Russia.

Materials and methods. The study was conducted online by distributing via social networks a direct link to an electronic form with questions about the attitude to the COVID-19 pandemic and vaccination. A total of 2,786 people (of whom 66.9% were women) aged 16 to 77 years took part in the online survey.

Results. It was shown that distrust of vaccination was more often expressed by women and younger people.  A targeted approach to these population groups can improve the results of awareness-raising and preventive measures in the context of an ongoing pandemic.
Сalprotectin in the blood plasma as a new biomarker for assessing the activity of rheumatoid arthritis
Authors: Korolkova A. A. , Khizha V. V. , Kozlova D. I. , Maslyanskiy A. L. , Vavilova T. V.
Published: October 2022

Aim. To study the potential use and information value of calprotectin in the blood plasma as a new biomarker for determining the activity of rheumatoid arthritis (RA).

Materials and methods. The study included 113 people. The treatment group consisted of 79 patients diagnosed with RA; the average age was 58 (± 11.66) years, the median duration of the disease was 10 [6; 15] years. The control group encompassed 34 healthy volunteers; the average age was 40 (± 11.14) years. RA activity was determined according to the Disease Activity Score (DAS) 28 and the Clinical Disease Activity Index (CDAI). The concentration of calprotectin in the blood plasma was determined by the solid-phase enzyme-linked immunosorbent assay. The obtained results were compared with laboratory and clinical parameters, as well as with composite indices (DAS28, CDAI) of RA activity. For mathematical data processing, Spearman’s rank correlation coefficient, linear discriminant analysis, and ROC analysis were used.

Results. In the group of patients with RA, the level of calprotectin in the blood was higher than in the control group. A statistically significant relationship was revealed between the level of calprotectin in the blood and all standard parameters of RA activity. The ROC analysis showed that the sensitivity, specificity, and diagnostic accuracy in assessing articular syndrome, as well as moderate and high RA activity according to the composite indices DAS28 and CDAI were higher for calprotectin than for erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). The linear discriminant analysis showed that a combination of ESR and calprotectin levels was the most informative; following it, the probability of correct classification of RA activity, according to the DAS28 index, was 71%. For the CDAI index, only one marker, calprotectin, resulted in a statistically significant classification with a probability of 70.5 %.

Conclusion. Сalprotectin in the blood plasma is a promising laboratory biomarker for assessing synovitis activity in RA demonstrating higher accuracy, sensitivity, and specificity than traditional acute-phase reactants.
The Potential Implementation of Biomass Co-firing with Coal in Power Plant on Emission and Economic Aspects: A Review
Authors: Triani Meiri , Tanbar Fefria , Cahyo Nur , Sitanggang Ruly , Sumiarsa Dadan , Lara Utama Gemilang
Published: October 2022

Applying coal-biomass co-firing power generation is the strategy to accelerate the renewable energy share in the energy mix to reach 23% by 2025. Although biomass co-firing trials have been carried out at several Coal-Fired Power Plants (CFPP), the potential for implementing biomass co-firing on a larger scale and for the long-term propose still needs to be identified. This article evaluates emission characteristics and economic aspects of implementing biomass and coal in power plants. The traditional review method is used by identifying journal articles as data sources and further elaborating according to the context of the study. The primary emissions from co-firing biomass with coal contain CO, SO2, NOx, and particulate matter. The coal-biomass co-firing power generation has been widely adopted due to its various positive effects. However, it is still necessary to consider the cost of retrofitting, OM, biomass prices, and incentives in its application.
The CSHQ-DE Questionnaire Uncovers Relevant Sleep Disorders in Children and Adolescents with Long COVID-19
Authors: Werner Sarah , Doerfel Claus , Biedermann Richard , Lorenz Michael , Rasche Marius , Proquitté Hans , Newman Lars , Vilser Daniel
Published: October 2022

Acute SARS-CoV-2 infections in children and adolescents are usually mild. However, they can suffer from ongoing symptoms generally referred as long COVID. Sleep disorders are one of the most frequent complaints in long COVID although precise data are missing. We assessed the sleep behavior of children and adolescents who presented at our outpatient clinic between January 2021 and May 2022 with the Children's Sleep Habits Questionnaire (CSHQ-DE). We compared sleep behavior at three different time points: pre-COVID-19, post-COVID-19 at initial presentation and post-COVID-19 at re-presentation. Data from 45 patients were analyzed. Of those, 64% were female and the median age was 10 years (range 0-18 years). Asymptomatic or mild COVID-19 disease was experienced in 89% of patients, whilst 11% experienced moderate disease. Initial presentation occurred at a median of 20.4 weeks (6 weeks - 14 months) after infection. The CSHQ-DE score increased significantly from pre-COVID-19 (45.82+8.7 points) to post-COVID-19 (49.40+8.3 points; p=<0.01). The score then normalized at re-presentation (46.98+7.8; p=0.1). The greatest changes were seen in the CSHQ-DE subscale score "daytime sleepiness". Our data show that children and adolescents with long COVID often suffer from sleep disturbance. For most children and adolescents these sleep disorders decreased over time without further medical intervention, aside from a basic sleep consultation.
Antioxidants and Long Covid
Authors: Chambers Patrick
Published: October 2022

Long Covid has many symptoms that overlap with ME(myalgic encephalomyelitis)/CFS(chronic fatigue syndrome), FM(fibromyalgia), EBV(Epstein-Barr virus), CMV(cytomegalovirus), CIRS (chronic inflammatory response syndrome), MCAS(mast cell activation syndrome), POTS(postural orthostatic tachycardia syndrome), and post viral fatigue syndrome. They all portend a “long haul” with an antioxidant shortfall and elevated Ca:Mg. Oxidative stress is the root cause. Linkage between TGF(transforming growth factor)-β, IFN(interferon)-γ, the RAS(renin angiotensin system), and the KKS(kallikrein kinin system) is discussed. Technical explanations for the renin aldosterone paradox in POTS, the betrayal of TGF-β, and the commonality of markers for the Warburg effect are offered. The etiology of the common Long Covid symptoms of post exertional malaise, fatigue, and brain fog as well as anosmia, hair loss, and GI symptoms is technically discussed. Ca:Mg is critical to the glutamate/GABA balance. The role of GABA and butyrates from the “good” intestinal bacteria in the gut-brain axis and its correlation with chronic fatigue diseases are explored. The crosstalk between the ENS(enteric nervous system) and the ANS(autonomic nervous system) and the role of the vagus in both are emphasized. HRV(heart rate variability), the fifth vital sign, points to an expanded gut-brain-heart/lung axis. A suggested approach to all of these - Long Covid, chronic fatigue diseases, post viral fatigue syndrome, and general health - is presented.
Recent Advances in Double-Lumen Tube Malposition in Thoracic Surgery: A Bibliometric Analysis and Narrative Literature Review
Authors: Zhang Xi , Wang Dong-Xu , Wei Jing-Qiu , Liu He , Hu Si-Ping
Published: October 2022

The thoracic surgery has increased drastically in recent years, especially in the light of the severe outbreak of 2019 novel coronavirus disease (COVID-19). Routine “passive” computed tomography of the chest screening of inpatients detects some pulmonary disease requiring thoracic surgeries timely. As an essential equipment for thoracic anesthesia, the double-lumen tube (DLT) in precise position is particularly important for anesthesia and surgery. With the continuous up-grading of the DLTs and the widespread use of the fiberoptic bronchoscopy (FOB), the position of DLT in thoracic surgery is gradually becoming more stable and easier to observe or adjust. However, for reasons such as transferring the patient to the lateral position, the DLT malposition still occurs in thoracic surgery, leading to lung isolation failure and hypoxemia during one-lung ventilation (OLV). Recently some innovative DLTs based on traditional have shown good results in reducing the incidence of DLT malposition, and some studies also found a lower malposition rate through improved intervention methods. This review aims to discuss and summarize the recent rates of left-sided DLT malposition, the reasons and effects of malposition, and to sum up current methods of reducing DLT malposition as well as prospects for possible approaches. Meanwhile, we use bibliometric analysis to summarize the research trends and hot spots of the DLT research.
Copaiba Oilresin Exerts an Additive Effect to the Babassu Oil on Behavioral Changes in Human Endometriotic Cell Cultures
Authors: Silva Julianna Henriques da , Abreu Leticia Coli Louvisse de , Ferrari Renato , Palmero Célia Yelimar , Barros Eliane Gouvêa de Oliveira , Cordeiro Natália de Moraes , Pontes Bruno , Sousa Valeria Pereira de , Cabral Lucio Mendes , Fernandes Patricia Dias , Nasciutti Luiz Eurico
Published: October 2022

Background: Current drug for the treatment of endometriosis is not able of completely cure and significant side effects hinder the continuation of treatment. So, the search for new drug candidates is necessary, and the use of plants extracts is highlighted. Babassu oil and copaiba oilresin have several therapeutic properties. We investigated the in vitro effects of two nanoemulsions containing babassu oil (Orbignya speciosa) (SNEDDS-18) and/or copaiba oilresin (Copaifera langsdorffii) (SNEDDS-18/COPA) on cultured human eutopic endometrium stromal cells from endometrial biopsies of patients without (CESC) and with (EuESC) endometriosis, and human stromal cells from biopsies of endometriotic lesions (EctESC). Methods: CESC, EuESC and EctESC were established and treated with SNEDDS-18 and SNEDDS-18/COPA to evaluate its effects on cytotoxicity, cell morphology, proliferation, and signaling pathways. Results: After 48 hours incubation with SNEDDS-18 and SNEDDS-18/COPA, cell viability and proliferation were inhibited, especially in EctESC. The lowest concentration of both nanoemulsions reduced cell viability and proliferation and breakdown the cytoskeleton in EctESCs. After 24h treatment it was observed a decrease in IL-1, TNF-α, and MCP-1, and an increase in IL-10 production. Conclusions: Both nanoemulsions can affect the endometriotic stromal cell behaviors, thus revealing two potential candidates for new phytotherapeutic agents on the management of endometriosis.
Nasopharyngeal Carcinoma Ecology Theory: Cancer as Multidimensional Spatiotemporal “Unity of Ecology and Evolution” Pathological Ecosystem
Authors: Luo Weiren
Published: October 2022

Nasopharyngeal carcinoma (NPC) is generally regarded as a genetic disease with diverse extent of intertumor and intratumor heterogeneity. Here we propose that, NPC is not only a genetic disease; it could be conceptualized as a multidimensional spatiotemporal “unity of ecology and evolution” pathological ecosystem. In the text, we first discuss NPC cells an invasive species and its metastasis as a multidirectional ecological dispersal, which consisting of four interdependent parts: primary ecosystem, circulating ecosystem, metastatic ecosystem and multidirectional ecosystem. We then interpreter the foundational ecological principles to understand NPC progression. The model of “mulberry-fish-ponds” can well illustrate the dynamic reciprocity of cancer ecosystem. Subsequently, we demonstrate that tumor-host interface is the ecological transition zone in cancers, and tumor buddings should be recognized as ecological islands separated from the mainland. Selection driving factors and ecological therapy including hyperthermia for NPC patients, and future perspectives of “ecological pathology”, “multidimensional spatiotemporal tumoriecology” and “integrated tumoriecology” are also pointed out. We advance that “nothing in cancer evolution or ecology makes sense except in the light of the other”. The essence of NPC and other human neoplasms should be pathological an “unity of ecology and evolution”. The establishment of “NPC ecology” might open up a new horizon, and provide a comprehensive framework for our understanding of the complex progression of this disease and development of potential preventive and therapeutic strategies for patients.
Using Biomimicry Science in the Design of a Kinetic Façade to Regulate the Amount of Daylight Entering a Working Space
Authors: Sankaewthong Sukhum , Horanont Teerayut , Miyata Kazunori , Karnjana Jessada , Busayarat Chawee , Xie Haoran
Published: October 2022

Today, buildings are increasingly designed with transparent materials, with glass paneling being especially popular as an installation material for its architectural allure. However, its major drawback is admitting impractical amounts of sunlight to interior spaces. Office buildings with excessive sunlight in indoor areas result in worker inefficiency. This article studied kinetic façades as means to providing suitable sunlight for interior spaces integrated with a triple identity of DNA structure, photosynthetic behavior, and the twist used, which was divided into generation and evaluation. The generating phase first used an evolutionary engine to produce potential strip patterns. The kinetic façade was subsequently evaluated by Climate Studio software to validate daylight admission in an indoor space with Leadership in Energy and Environmental Design (LEED) version 4.1 criteria. To analyze the kinetic façade system, the building envelope was divided into four types: glass panels, static façades, kinetic façade (version 1, rotating movement), and kinetic façades (version 2, twisting movement). In addition, for kinetic façades, degrees of simulation for versions 1 and 2 were 20, 50, 80, and 100 degrees, in order to ascertain potential for both façades to the same degree. Comparing all façades receiving the daylight factor (DF) into the space from more or less sunlight resulted in the decreasing order of potential as follows: entirely glass façade, kinetic façade version 2, kinetic façade version 1, and static façade. By receiving daylight factor (DF), the façade filtered appropriate amounts of daylight into the working space moderately and beneficially. Daylight simulation results indicated that the newly designed kinetic façade (version 2) had more potential than other building envelope types in terms of filtering beneficial daylight in indoor areas. This article also experimented with the kinetic façade prototype in an actual situation to test conditional environmental potential. The kinetic façade (version 2) was explored in the building envelope with varied adaptability in order to provide sunlight and for private-to-public, public-to-private, or semi-public working areas.
Mechanisms of Male Reproductive Toxicity of Polybrominated Diphenyl Ethers
Authors: Arowolo Olatunbosun , Pilsner J. Richard , Sergeyev Oleg , Suvorov Alexander
Published: October 2022

Polybrominated diphenyl ethers (PBDE) are a group of flame retardants used in a variety of artificial materials. Despite phasing out in most industrial countries, they persist in the environment and human tissues due to their persistence, lipophilicity, and bioaccumulation. Populational and experimental studies demonstrate male reproductive toxicity of PBDEs including increased incidence of genital malformations (hypospadias and cryptorchidism), altered weight of testes and other reproductive tissues, altered testes histology and transcriptome, decreased sperm production and sperm quality, altered epigenetic regulation of developmental genes in spermatozoa and altered secretion of reproductive hormones. A broad range of mechanistic hypotheses of PBDE reproductive toxicity has been suggested. Among these hypotheses, oxidative stress, disruption of estrogenic signaling, and mitochondria disruption are affected by PBDE concentrations much higher, than concentrations found in human tissues, making them unlikely links between exposures and adverse reproductive outcomes in the general population. Robust evidence suggests that at environmentally relevant doses, PBDEs and their metabolites may affect male reproductive health via mechanisms including AR antagonism and the disruption of a complex network of metabolic signaling.