bluuebunny/crossref_metadata_2025 huggingface dataset:
Suitability of ZnO Nanocomposite of Copolymer (PPy-PNVK-ZnO) (PPy = Polypyrrole;
PNVK = Poly 9-vinyl carbazole) for the Detection of 6-Thioguanine: A DFT Analysis
Authors: Khare Kirtesh Pratap , Kathal Rachana , Shukla Neelima , Srivastava Reena , Srivastava Anurag
Published: January 2023

Conducting polymers have extensively been exploited for the specific drug detection, through diverse
drug responses. 6-Thioguanine (6-TG) is commonly used in the treatment of cancer and its level
monitoring in the human body is essential to avoid the side effects due to its physiological metabolites.
Computational synthesis of a novel sensor material, i.e. ZnO nanocomposite of copolymer
(PPy-PNVK-ZnO) using polypyrrole (PPy-ZnO) and poly 9-vinyl carbazole (PNVK-ZnO) polymers,
has been performed and investigated its sensing ability for 6-TG drug, using the density functional
theory (DFT) based ab initio approach. Generalized gradient approximation (GGA), parameterized
with Perdew, Burke and Ernzerhof (PBE) type parameterization furnishes novel resources on the
studied molecular model. The molecular interactions have been analyzed in terms of the HOMO-LUMO
gap, density of states (DOS), adsorption energy (Eads), recovery time (τ), Mulliken population, electron
density plot and quantum molecular descriptors. The calculated negative adsorption energy confirms
the stability of these polymers and observes the type of interaction with 6-TG, as physical adsorption,
that also confirms the reusability of the prepared sensor and its low operational temperature. It has
also been observed that ZnO nanocomposite of copolymer has favourable stability in comparison to
its host counterparts, whereas the host PNVK has a better recovery time and PPy has a relatively better
range of detection and highly reactive.
Nickel(II) Complexes of Octamethyl Tetraazamacrocycle and its N-Pendent Derivative:
Syntheses, Characterization, Electrolytic Behaviour and Antimicrobial Activities
Authors: Amin Ruhul , Rabi Saswata , Barua Lira , Uddin M. Nasir , Morshed M. Imtiaz , Rahman Ismail M.M. , Roy Tapashi Ghosh
Published: January 2023

Octamethyl tetraazamacrocycle, Me8[14]diene·2HClO4 and its three isomeric ligands (LA, LB and LC)
were synthesized and characterized using analytical and spectroscopic data, and the antibacterial
activities were evaluated against selected bacteria and yeast. Interaction of LC with excess acrylonitrile
resulted in an N-pendent derivative (LCX). Square planar nickel(II) diperchlorate complex of LC,
[NiLCα](ClO4)2, underwent axial addition reactions with KI and NaNO2 to yield six coordinated
octahedral species, [NiLCαI2]·2H2O and [NiLCα(NO2)(ClO4)]. Five coordinated square pyramidal Ni(II)
complexes, [NiLCXCl](ClO4), [NiLCX(NCS)](NO3) and [NiLCXI](NO3), were synthesized from Ni(II)
salts and tetraazamacrocyclic ligand LCX. Among the complexes, [NiLCXCl](ClO4) was synthesized
through the direct interaction of NiCl2 with LCX, followed by the subsequent addition of NaClO4·6H2O.
On the other hand, [NiLCX(NCS)](NO3) and [NiLCXI](NO3) as well as octahedral [NiLCXBr2] and
[NiLCX(NO2)(NO3)] were synthesized by the interaction of LCX with different Ni(II) salts.
Code Ocean “Enabling Reproducibility” SSP – Chicago, June 2-3, 2022
Authors: Grenier Gerry
Published: January 2023

Code Ocean provides researchers a platform to share their computational research, supporting reproducibility. Learn how authors can create, manage, preserve and share the code, data, and environment associated with their journal article. Learn how Code Ocean’s platform enables editors and reviewers to examine an author’s software code before publication – in effect peer reviewing the code. Learn how the software code can easily be embedded into an online journal article as an executable “capsule” – allowing readers to download a copy of the code, examine it, learn from it, and alter the code for their own purposes. Learn how publishers can offer this service to their authors and readers with minimal technology set-up.
Building Bridges during a Global Pandemic: The Story of the SSP-DC Regional Subcommittee and COVID-19
Authors: Farrell Ryan , Guinnessy Paul , Gurstelle Jon , Iglesias Violaine , Lang Jeff , Long John , Orr Christine , Pittman Ginny , Regala Jennifer , Warren John , White Adrienne , Wooden Paige
Published: January 2023

The SSP-DC Regional Subcommittee, co-chaired by Paige Wooden and Jennifer Regala, has always enjoyed a robust, loyal, and enthusiastic following. Pre-pandemic, the group served as an extension of the larger Society for Scholarly Publishing, allowing professionals in the DC area to meet often and in-person to network and partake in educational events and conversation. The group held its last event before the quarantine on January 29, 2020. “Career Development Lab: Professional Development and Transferable Skills in Scholarly Publishing” hosted individuals, including students and professionals in varying stages of their careers, in a career development lab format, which showcased “a networking opportunity and panel-audience discussion on the profession of scholarly publishing, developing your career, and mentoring others.” Of course, no one knew at that
Chemical constituents and in vivo preliminary evaluation of the toxicological activity of Ouratea spectabilis (OCHNACEAE) and Clitoria guianensis (Fabaceae) leaves
Authors: Sousa Frank Bruno Vieira de , Cruz Állefe Barbosa , Soares Daniela Francisca , Cunha Camila Luiza , Holzbach Juliana C.
Published: January 2023

Clitoria guianensis and Ouratea spectabilis, found in the Brazilian Cerrado, are used in folk medicine, despite the few chemical and biological studies reported in the literature. The present study aims to investigate the toxicity and effect of extracts from both species on the microcrustacean Artemia salina, and to determine the chemical composition of the hexane extract of O. spectabilis leaves and the EtOAc fraction of C. guianensis leaves. Kaempferitrin, a flavonoid isolated from of the EtOAc fraction of C. guianensis leaves, was identified by chemical analysis. Analysis of the hexane extract of O. spectabilis leaves using gas chromatography-mass spectrometry (GC-MS) suggested the presence of twenty-five known substances. The Hex, EtOAc, and EtOH crude extracts of C. guianensis leaves exhibited high and moderate toxicity against Artemia salina, with median lethal dose values (LD50) of 43.7, 25.4, and 233.4 mg.L−1, respectively. The acetone extract of O. spectabilis leaves showed moderate toxicity against Artemia salina with an LD50 value of 115.13 mg.L−1.
Molecular analysis of the prevalence of Acinetobacter baumannii in hospitals and the surrounding environments: a cross-sectional study
Authors: Silva Kerollyn  Fernandes Bernardes , Miguel Camila Botelho , Oliveira Júnior Rony Rocha de , Araujo Marcelo Costa , Agostinho Ferdinando , Ueira-Vieira Carlos , Lazo-Chica Javier Emilio , Rodrigues Wellington
Published: January 2023

Acinetobacter baumannii is widely recognized in clinical environments due to its infectious capacity, antimicrobial adaptability, and lethality. Analyzing the prevalence of this agent in intra- and extra-hospital environments may reveal target indicators for appropriate management interventions. In this observational cross-sectional study, we evaluated the prevalence of A. baumannii within hospitals with intensive care units and in their external surroundings in a macro-health region of Brazil. Samples of Columba livia (pigeon) droppings from the external environment of four hospitals (n = 40), from floor surfaces (n = 20), and door handles (n = 20) of different hospital wards were collected based on random sampling, all of which were evaluated for the presence of A. baumannii using polymerase chain reactions (PCR). The sensitivity and specificity of the technique was verified after the collected samples were contaminated with clinical samples positive for A. baumannii. We detected a significantly higher A. baumannii prevalence (87.50%, CI = 71.29–100.00) in samples collected within the hospital environment compared with those obtained from the external environment (12.50%, CI = 0.00–28. 71) (p = 0.003). In addition, samples collected from floor surfaces contained bacterial densities (181.3 ± 11.58) that exceeded those in environmental (93.32 ± 1.56) and door handle (142.70 ± 17.14) samples by 94% and 78.71%, respectively. The findings of this study will enhance our understanding of the spatial distribution of A. baumannii and additionally, validate the efficiency of PCR for diagnosis of this infectious agent.
Digital Approaches for Public Art Collection Between Conservation and Public Outreach
Authors: Gasparetto Francesca , Baratin Laura , Checcucci Giovanni
Published: January 2023

Digital tools for artworks can offer new opportunities and design new approaches for conservation and public outreach.  This paper presents the experience carried out by the School of Conservation and Restoration of the University of Urbino to preserve a public collection of wooden artistic models assembled by Umberto Mastroianni and used as a project of original bronze and steel sculptures. The digital documentation supported the maintenance protocol and helped design the restoration work. Moreover, thanks to cutting-edge technologies, a virtual exhibition was created, testing an AR application that allows the public to better appreciate the results of the interventions. Digital storytelling about artistic meaning connected the models to original sculptures placed in various Italian landscapes, offering the public an artistic journey into Urbino’s architecture.
Autofiktionale Generationenerzählungen in den aktuellen Romanen über postsowjetische Migration: Zu Sasha M. Salzmanns „Im Menschen muss alles herrlich sein" (2021), Lena Goreliks „Wer wir sind"(2021 ) und Dmitrij Kapitelmans „Eine Formalie in Kiew" (2021)
Authors: Rutka Anna , Dubrowska Małgorzata
Published: January 2023

Der vorliegende Beitrag untersucht drei 2021 erschienenen Prosatexte von Vertreter*innen der russisch-ukrainisch-jüdischen postmigrantischen Generation unter dem Gesichtspunkt der darin problematisierten Konflikte mit der Generation der Eltern.  Die autofiktionalen Familiengeschichten Goreliks, Kapitelmans und Salzmanns rekurrieren aus der Perspektive der Kinder auf die sowjetischen Erfahrungen der Eltern und ergründen die gegenseitige Entfremdung. In diachroner Achse der Generationenerzählung werden Rekapitulationsversuche unternommen, das sowjetische Erbe und die familiäre Migration aus dem transnationalen Blick des Ankommens zu reflektieren. Die synchrone Dimension der Romane  verhandelt komplizierte Prozesse der Selbstermächtigung und kritischer Interventionen in die deutsche Gesellschaft. Mit jeweils unterschiedlichen ästhetischen Mitteln des Satirisch-Ironischen, episodenhaft-diskontinuierlichen Erzählens und Perspektivenwechsel-Spiels dokumentieren die Texte souveräne Selbstbestimmung und Selbsermächtigung der postmigratnischen Autor*innen in der deutschen Literaturszene.
On the Move – Überlegungen zu Carmen Francesca Bancius Langgedicht Lebt wohl ihr Geliebten und Genossen (2018) und Jaroslaw Rudiš Roman Winterbergs letzte Reise (2019)
Authors: Wolting Stephan
Published: January 2023

Innerhalb des Beitrags wird am Beispiel zweier Werke mitteleuropäischer AutorInnen, die in ihrer „Nichtmuttersprache“ Deutsch schreiben, der Versuch unternommen, literarische Darstellungen von Migrationsdiskursen unter dem Fokus zweier extrem gegenläufiger aktueller, theoretischer Positionen zu betrachten: der „Move“ (Khanna 2021), wonach die Migration, als das „Normalitätserwartung“ und die Sesshaftigkeit als Ausnahme gilt. Zum anderen geht es um die Solastalgie als das „Heimweg ohne Exil“. Beide Werke machen darauf aufmerksam, dass in einer globalisierten und sich immer stärker vernetzenden Welt die eigene Umgebung selbst zur Fremde mutiert, sodass als einzige Möglichkeit bleibt, unterwegs. also on the move, zu bleiben.
Zoo-integracje. Śladem Bydlęcego brzemienia Sunaury Taylor
Authors: Jarzyna Anita
Published: January 2023

Artykuł stanowi kontekstowe omówienie pionierskiej książki Sunaury Taylor Bydlęce brzemię. Wyzwolenie ludzi z niepełnosprawnościami i zwierząt, poświęconej paralel- nej krytyce antropocentryzmu i ableizmu jako dwu zazębiających i wspierających się systemów opresji. W recenzji zwrócono uwagę na perspektywy (krytycznego) wykorzystania tez amerykańskiej badaczki w studiach literaturoznawczych, wskazane zostały przykłady konkretnych utworów, zasługujących na reinterpretacje w tak zakreślonych ramach.
„Wielu chłopców stąd uciekało”. Migracje nietypowe w artystyczno-literackich ujęciach Szopienic Kazimierza Kutza, Henryka Bereski i Hilarego Krzysztofiaka
Authors: Tomczok Marta
Published: January 2023

Artykuł jest próbą prześledzenia migranckich losów urodzonych w Szopienicach (dzielnicy Katowic) artystów: Kazimierza Kutza, Henryka Bereski i Hilarego Krzysztofiaka na podstawie ich twórczości. Sięgając po pojęcie migracji nietypowych, autorka analizuje przyczyny powojennych wyjazdów mieszkańców katowickiej dzielnicy (rodzinne, tożsamościowe, edukacyjne, zdrowotne) na szerokim tle migracji Ślązaków po 1945 roku, zwłaszcza do Niemiec. Migracje artystyczne stają się w tym układzie rozbudowaną refleksją na temat zjawiska badanego dotąd rzadko i rozproszonego, dostarczając materiału nie tylko historykom literatury czy sztuki, ale też socjologom. Na analizę składają się część poświęcona pograniczu, jałowej ziemi i estetyce przedstawień migracji. W konkluzji pojawia się propozycja rozumienia jej ujęć poza autobiografią, na kilku poziomach – w tym biografii zbiorowej mieszkańców dzielnicy (Kutz) i ponadindywidualnych obserwacji (Bereska), osadzających doświadczenie granic, nawet po ich usunięciu, w biografiach ludzi XX i XXI wieku.
Słupskie dyskursy migracyjne. Konteksty literaturoznawcze i teatralne
Authors: Sobiecka Anna
Published: January 2023

Artykuł prezentuje narracje migracyjne (założycielskie i tożsamościowe) kulturowej przestrzeni miasta Słupska oraz ich konteksty teatralne. Punktem wyjścia staje się analiza porównawcza mikrohistorii lokalnych zapisanych w tekstach dokumentu osobistego: nieopublikowanych dotąd Wspomnieniach pierwszych słupszczan i opublikowanych wspomnieniach słupskich osadników Mój nowy dom (2009). Przykłady lokalnych narracji migracyjnych skonfrontowane zostają z ustaleniami teoretycznoliterackimi w zakresie literackich świadectw dyskursu tożsamościowego i memorialnego.
Degenerate time-fractional diffusion equation with initial and initial-boundary conditions
Authors: Smadiyeva Asselya G.
Published: January 2023

In this paper, we study initial and initial-boundary problems for the time-fractional degenerate diffusion equations in bounded and unbounded domains. We obtain the existence and uniqueness of solutions using Fourier methods.
The
R
∞
R_{\infty}
property for nilpotent quotients of Generalized Solvable Baumslag–Solitar groups
Authors: Sgobbi Wagner C. , Silva Dalton C. , Vendrúscolo Daniel
Published: January 2023

We say a group 𝐺 has property

R
∞

R_{\infty}

if the number

R
⁢

(
φ
)

R(\varphi)

of twisted conjugacy classes is infinite for every automorphism 𝜑 of 𝐺.
For such groups, the

R
∞

R_{\infty}

-nilpotency degree is the least integer 𝑐 such that

G
/

γ

c
+
1

⁢

(
G
)

G/\gamma_{c+1}(G)

has property

R
∞

R_{\infty}

.
In this work, we compute the

R
∞

R_{\infty}

-nilpotency degree of all Generalized Solvable Baumslag–Solitar groups

Γ
n

\Gamma_{n}

.
Moreover, we compute the lower central series of

Γ
n

\Gamma_{n}

, write the nilpotent quotients

Γ

n
,
c

=

Γ
n

/

γ

c
+
1

⁢

(

Γ
n

)

\Gamma_{n,c}=\Gamma_{n}/\gamma_{c+1}(\Gamma_{n})

as semidirect products of finitely generated abelian groups and classify which invertible integer matrices can be extended to automorphisms of

Γ

n
,
c

\Gamma_{n,c}

.
Isolated tortuous ductus arteriosus in a fetus: HDlive Flow with spatiotemporal image correlation (STIC) study
Authors: Hata Toshiyuki , Kawahara Tomomi , Konishi Miyu , Bouno Saori , Yamanishi Tomomi , Koyanagi Aya , Miyake Takahito
Published: January 2023

Objectives

To describe prevalence, outcome, color Doppler, and HDlive Flow (Silhouette) with spatiotemporal image correlation (STIC) features of isolated tortuous ductus arteriosus in Japanese fetuses at 28–31 + 6 weeks of gestation.

Methods

During a 37-month period, 3,150 fetal screenings were performed at 28–31 + 6 weeks of gestation. Isolated tortuous ductus arteriosus was evaluated using color Doppler and HDlive Flow (Silhouette) with STIC. Prevalence and outcomes were also assessed.

Results

There were 22/3,150 fetuses (0.7%) had isolated tortuous ductus arteriosus at 28–31 + 6 weeks of gestation. According to color Doppler and HDlive Flow findings, two types of isolated tortuous ductus arteriosus (Right-angled and Loop shapes) were classified. There were 20 Right-angled and 2 Loop shapes. One fetus with a Right-angled shape was associated with aortic tortuosity. HDlive Flow with STIC revealed spatial relationships of tortuous ductus arteriosus, aortic arch, and descending aorta. All fetuses with isolated tortuous ductus arteriosus had good neonatal outcomes.

Conclusions

The incidence of isolated tortuous ductus arteriosus in Japanese fetuses was low compared with those in previous reports. HDlive Flow with STIC provides precise information for spatial recognition and differentiation of isolated tortuous ductus arteriosus, resulting in two type classifications. Isolated tortuous ductus arteriosus in a fetus may be a transient, benign finding in utero.
Crystal structure of E-7-fluoro-2-(4-methoxy-3-(trifluoromethyl)benzylidene)-3,4-dihydronaphthalen-1(2H)-one, C19H14F4O2
Authors: Liu Yi-Bin , Xu Yang-Rong , Wang Wen-Shui , Jiang Sheng , Zhao Feng-Lan , Meng Qing-Guo
Published: January 2023

C19H14F4O2, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 8.3798(6) Å, b = 9.2019(7) Å, c = 10.4504(7) Å, α = 77.941(6)°, β = 85.712(6) , γ = 79.078(6)°, V = 773.25(10) Å3, Z = 2, R

gt
(F) = 0.0458, wR

ref
(F
2) = 0.1165, T = 100 K.
The crystal structure of cis-Dicyano-bis(2,2′-bipyridine)k2
N,N′-chromium(III) hexafluorophosphate, C22H16N6F6PCr
Authors: Zhuo Linhai , Zhang Jinjun
Published: January 2023

C22H16N6F6PCr, orthorhombic, P212121 (no. 19), a = 11.3511(7) Å, b = 12.1350(8) Å, c = 17.3820(11) Å, V = 2394.3(3) Å3, Z = 4, R

gt
(F) = 0.0388, wR

ref
(F
2) = 0.1023, T = 293 K.
Crystal structure of 4-((6-bromohexyl)oxy)-2-hydroxybenzaldehyde, C13H17BrO3
Authors: Zhao Wen-Ze
Published: January 2023

C13H17BrO3, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 8.5759(12) Å, b = 9.1690(12) Å, c = 9.9698(12) Å, α = 81.677(4)°, β = 76.029(4)°, γ = 63.441(4)°, V = 679.87(16) Å3, Z = 2, R
gt(F) = 0.0433, wR
ref(F
2) = 0.1253, T = 302(2) K.
Crystal structure of 1-(2-iodobenzoyl)-6-methoxy-1H-indole-3-carbaldehyde, C17H12INO3
Authors: Sun Yi-Fan , Tang Qian-Qian , Zhang Yue , Yang Fan , Liu Yong-Jun , Cong Wei
Published: January 2023

C17H12INO3, monoclinic, P21/n (no. 14), a = 7.5319(5) Å, b = 7.9745(5) Å, c = 25.1313(17) Å, β = 98.459(7)°, V = 1493.04(17) Å3, Z = 4, R

gt
(F) = 0.0272, wR

ref
(F
2) = 0.0595, T = 199.98(10) K.
Nitric acid-potassium hydroxide fractionation of rice straw: an integrated biorefinery initiative
Authors: Rahman M. Mostafizur , Rafsan Nur-Al-Sarah , Nayeem Jannatun , Popy Razia Sultana , Moniruzzaman Mohammad , Jahan M. Sarwar
Published: January 2023

Pulping of rice straw was studied using mild nitric acid in mild conditions. Spent nitric acid was chosen as soil nutrient rather than followed by the liquor recovery. The rice straw was treated with 11.03% nitric acid at 90 °C for 3 h, yielded 53.09% pulp. Nitric acid treated rice straw pulp had high residual lignin and minerals. However, further treatment with 7% potassium hydroxide reduced the residual lignin and produced pulp with kappa number 20.36. The papermaking properties of the nitric acid followed by KOH treated pulp showed better quality than the nitric acid pulp. The spent nitric acid liquor was reused repeatedly, pulp yield decreased and residual lignin content increased in each step of spent nitric acid reusing. The spent nitric acid liquor and potassium hydroxide liquor-mixed together to get a neutral effluent liquor which was rich with potassium, nitrogen and biomass. The nutritional capacity of the effluent liquor was assessed by incubation with control soil. The labile form of organic carbon, nitrogen, potassium phosphorous and iron increased in the incubated soil.
Sustainable amidation through acceptorless dehydrogenative coupling by pincer-type catalysts: recent advances
Authors: Montag Michael , Milstein David
Published: January 2023

The amide functional group is ubiquitous in living organisms, and is of particular importance in bioactive compounds and pharmaceuticals. Because of the prevalence and significance of the amide bond, considerable efforts have been invested throughout the years in developing new synthetic methodologies for its formation. Nevertheless, amide synthesis still largely relies on variants of the traditional condensation of carboxylic acids and amines, mediated by stoichiometric coupling reagents. This poses a sustainability challenge, since such reactions suffer from unfavorable atom and step economies, involve harmful chemicals and produce chemical waste. Hence, establishing sustainable approaches to amide synthesis is of great importance. Over the last two decades, we have developed homogeneous catalytic reactions for sustainable synthetic transformations, primarily based on transition metal complexes of pincer ligands. A considerable portion of these efforts has been devoted to acceptorless dehydrogenative coupling, including that of alcohols and amines through ruthenium-catalyzed reactions. These latter processes generate amides without resorting to coupling reagents and typically produce no waste, with their only byproduct being H2 gas, which is itself a valuable resource. In the present review, we chronicle our progress in this area of research since 2014. This includes the use of water and ammonia as amidation reagents, expanding the scope of amidation substrates and target amides, achieving milder reaction conditions, development of amidation-based liquid organic hydrogen carrier systems, and introduction of manganese-based catalysts.
Inflammation parameters, monocyte subgroups and toll-like receptor expression before and after dialysis in patients with chronic kidney disease
Authors: Kivanc Demet , Savran Oguz Fatma , Senturk Ciftci Hayriye , Aydin Filiz , Sever Mehmet Sukru
Published: January 2023

Objectives

The data of the monocyte subgroups and expressed toll like receptors (TLR) in the innate immune system response, which develop against chronic inflammation in patients with predialysis chronic kidney disease (CKD) and in patients who undergo dialysis treatment, are limited. We aimed to investigate the effect of the dialysis procedure on the current chronic inflammatory condition and which role of monocyte subgroups ratios, the expressions of TLR2/4 and serum Tumor necrosis factor alpha (TNF-α) levels involved in the innate immune response process.

Methods

We investigated monocyte subgroups, TLR2/TLR4 expressions and serum TNF-α levels in 30 predialysis CKD patients, 90 CKD patients undergoing dialysis and 30 healthy control subjects. Monocyte subgroup percentages and TLR2/TLR4 expressions were determined using the flow cytometry, serum TNF-α levels were investigated using the enzyme-linked immunosorbent assay (ELISA).

Results

In the dialysis patients, the percentages of classical (p=0.0001) and non-classical (p=0.078) monocytes were found to be higher when compared with the predialysis CKD patients. The percentages of TLR4 expression on non-classical monocytes was higher in dialysis and predialysis patients compared with the healthy controls (p<0.0001, p=0.796). Serum TNF-α level was significantly higher in dialysis and predialysis patients compared with the healthy controls (p=0.013, p=0.022) and a positive correlation between the classical monocyte subgroup and TNF-α was observed (r=0.285, p=0.006).

Conclusions

Increased percentages of non-classical monocytes, TLR4 expressions and serum TNF-α levels observed in the predialysis CKD patients and dialysis patients might be related to inflammation.
La aeroterapia como reivindicación de la fisiología de las alturas, 1893-1907
Authors: Serrano Juárez José Daniel
Published: January 2023

A mediados del siglo XIX se desató una polémica sobre la capacidad intelectual de los habitantes de las altiplanicies. Con base en la metodología fisiológica se estableció que el volumen de oxígeno inhalado disminuye en las grandes altitudes, por lo que el raciocinio disminuía en esas condiciones. En 1899, a través del uso de instrumentos de medición, Daniel Vergara Lope y Alfonso Luis Herrera refutaron los principios de la “fisiología de las alturas” y enviaron su investigación al Instituto Smithsoniano, del que recibieron una distinción. Sin embargo, el trabajo del primero no se detuvo ahí, sino que en los siguientes años sostuvo que incluso el “aire enrarecido” incluso podría aprovecharse para el tratamiento de algunas enfermedades. A través del estudio de los trabajos que Vergara Lope publicó en la Memorias de la Sociedad Científica “Antonio Alzate” este trabajo tiene el objetivo de mostrar el intento del médico mexicano por fundar una nueva terapéutica que reivindicara la fisiología de las alturas a finales del siglo XIX.
Un mosaico de ideas: explicaciones en torno a la etiología de las enfermedades gastrointestinales durante el último tercio del siglo XIX
Authors: Olguín Ortiz Sheila , Martínez Rivera Luz del Carmen
Published: January 2023

Durante el último tercio del siglo XIX, los médicos, preocupados por el alto índice de mortandad y su repercusión en el desarrollo económico del país, intentaron explicar los principales padecimientos que afectaban a la población, entre ellos, las enfermades gastrointestinales: enteritis, colitis, enterocolitis, gastroenteritis y diarrea. Ideas como la influencia de la alimentación, las bacterias, el medio ambiente y los miasmas, fueron el marco del que se sirvieron estos profesionales para intentar dar cuenta de su etiología, En ese tenor, lejos de suscribir una postura, retomaron de cada una los elementos que, consideraban respondían acertadamente sus interrogantes respecto a la mortandad causada por esas afecciones.
Martín Escobedo Delgado y Almudena Gómez Ortiz, La Quemada. El sitio arqueológico según Edmond Guillemin-Tarayre (1866)
Authors: Domínguez Cardiel Jesús
Published: January 2023

Reseña a: Martín Escobedo Delgado y Almudena Gómez Ortiz, La Quemada. El sitio arqueológico según Edmond Guillemin-Tarayre (1866), Zacatecas: Taberna Libraria Editores, 2019, 219 pp.
Elizabeth Jelin y Ricard Vinyes, Cómo será el pasado. Una conversación sobre el giro memorial
Authors: Flores Miranda Víctor Adán
Published: January 2023

Reseña a: Elizabeth Jelin y Ricard Vinyes, Cómo será el pasado. Una conversación sobre el giro memorial, Barcelona: Ned Ediciones, 2021, 122 pp.
Esther Acevedo, Desde qué mirada vieron los franceses a México: L´Illustration, Journal Universel, 1843-1875
Authors: Hernández Guzmán Arturo
Published: January 2023

Reseña a: Esther Acevedo, Desde qué mirada vieron los franceses a México: L´Illustration, Journal Universel, 1843-1875, México, Secretaria de Cultura, Instituto Nacional de Antropología e Historia, 2019, 255 pp.
Development of the Functional Connectome Topology in Adolescence: Evidence from Topological Data Analysis
Authors: Gracia-Tabuenca Zeus , Díaz-Patiño Juan Carlos , Arelio-Ríos Isaac , Moreno-García Martha Beatriz , Barrios Fernando A. , Alcauter Sarael
Published: January 2023

Adolescence is a crucial developmental period in terms of behavior and mental health. Therefore, understanding how the brain develops during this stage is a fundamental challenge for neuroscience. Recent studies have modeled the brain as a network or connectome, mainly applying measures from graph theory, showing a change in its functional organization, such as an increase in its segregation and integration. Topological Data Analysis (TDA) complements such modeling by extracting high-dimensional features across the whole range of connectivity values instead of exploring a fixed set of connections. This study inquires into the developmental trajectories of such properties using a longitudinal sample of typically developing human participants (N = 98; 53/45 female/male; 6.7–18.1 years), applying TDA to their functional connectomes. In addition, we explore the effect of puberty on individual developmental trajectories. Results showed that the adolescent brain has a more distributed topology structure compared with random networks but is more densely connected at the local level. Furthermore, developmental effects showed nonlinear trajectories for the topology of the whole brain and fronto-parietal networks, with an inflection point and increasing trajectories after puberty onset. These results add to the insights into the development of the functional organization of the adolescent brain.
The Amyloid Precursor Protein Modulates the Position and Length of the Axon Initial Segment
Authors: Ma Fulin , Akolkar Himanshu , Xu Jianquan , Liu Yang , Popova Dina , Xie Jiaan , Youssef Mark M. , Benosman Ryad , Hart Ronald P. , Herrup Karl
Published: January 2023

The amyloid precursor protein (APP) is linked to the genetics and pathogenesis of Alzheimer's disease (AD). It is the parent protein of the β-amyloid (Aβ) peptide, the main constituent of the amyloid plaques found in an AD brain. The pathways from APP to Aβ are intensively studied, yet the normal functions of APP itself have generated less interest. We report here that glutamate stimulation of neuronal activity leads to a rapid increase inAppgene expression. In mouse and human neurons, elevated APP protein changes the structure of the axon initial segment (AIS) where action potentials are initiated. The AIS is shortened in length and shifts away from the cell body. The GCaMP8f Ca2+reporter confirms the predicted decrease in neuronal activity. NMDA antagonists or knockdown ofAppblock the glutamate effects. The actions of APP on the AIS are cell-autonomous; exogenous Aβ, either fibrillar or oligomeric, has no effect. In culture, APPSwe(a familial AD mutation) induces larger AIS changes than wild type APP. Ankyrin G and βIV-spectrin, scaffolding proteins of the AIS, both physically associate with APP, more so in AD brains. Finally, in humans with sporadic AD or in the R1.40 AD mouse model, both females and males, neurons have elevated levels of APP protein that invade the AIS.In vivoasin vitro, this increased APP is associated with a significant shortening of the AIS. The findings outline a new role for the APP and encourage a reconsideration of its relationship to AD.

SIGNIFICANCE STATEMENTWhile the amyloid precursor protein (APP) has long been associated with Alzheimer's disease (AD), the normal functions of the full-length Type I membrane protein have been largely unexplored. We report here that the levels of APP protein increase with neuronal activity.In vivoandin vitro, modest amounts of excess APP alter the properties of the axon initial segment. The β-amyloid peptide derived from APP is without effect. Consistent with the observed changes in the axon initial segment which would be expected to decrease action potential firing, we show that APP expression depresses neuronal activity. In mouse AD models and human sporadic AD, APP physically associates with the scaffolding proteins of the axon initial segment, suggesting a relationship with AD dementia.
The Role of Causal Attributions in Observational Conditioning
Authors: Kasran Sarah , Hughes Sean , De Houwer Jan , Beckers Tom
Published: January 2023

Our behavior towards a stimulus can change as a result of observing a regularity between that stimulus and someone else’s emotional reaction, a type of social learning referred to as observational conditioning. We explore the idea that causal attributions (i.e., the extent to which the observer attributes the model’s reaction to the stimulus) play an important role in observational conditioning effects. In three experiments (total N = 665), participants watched videos in which one cookie was followed by a positive reaction and another cookie was followed by a negative reaction, after which their own evaluations of each cookie were measured via self-reports and an implicit association test (IAT). Critically, we manipulated whether the observed reactions were high or low in terms of distinctiveness (Experiments 1a and 1b) or consensus and consistency (Experiment 2). These three variables are known to influence stimulus attributions and were therefore predicted to moderate observational conditioning effects. In line with our predictions, high distinctiveness (Experiments 1a and 1b) and high consensus and consistency (Experiment 2) both resulted in larger observational conditioning effects, with one exception: high distinctiveness did not lead to larger changes in automatic evaluations (i.e., IAT effects). Taken together, our findings suggest that causal attributions play an important role in observational conditioning. We outline more elaborate analyses of the attributional processes that are involved and suggest potential future directions for research on observational conditioning.
Pentecostalism and Power in Guatemala
Authors: Garrard Virginia
Published: January 2023

Guatemala is the most Protestant country in Latin America, with a rising population of Pentecostals. Although evangelicals have had substantial social and political influence for decades—one of them was a military dictator at the height of the country’s civil war in the early 1980s, and was later tried for genocide—many remain ambivalent about direct engagement with secular power. Instead, evangelical groups have been active in addressing gaps left by the state in a society struggling with violence, in areas such as education, social services, and security.
Colombia Tries a Transformative Left Turn
Authors: Freeman Will
Published: January 2023

In 2022, Colombia elected its first leftist president in decades, Gustavo Petro. For decades, Colombian politics had been characterized by strong center-right parties, the hard-right populism of ex-president Álvaro Uribe, and regional family dynasties. Under Petro’s predecessor, however, each of these structures weakened and Colombia entered an accelerated period of change. Petro won on the promise of shepherding Colombia through a dual transition: from endemic violence to “total peace,” and from reliance on fossil fuels to green development. But even with a pro-government majority in Congress, mounting debt and inflation constrained his ability to deliver.
TSC2 regulates tumor susceptibility to TRAIL‐mediated T‐cell killing by orchestrating mTOR signaling
Authors: Lin Chun‐Pu , Traets Joleen J H , Vredevoogd David W , Visser Nils L , Peeper Daniel S
Published: January 2023

Resistance to cancer immunotherapy continues to impair common clinical benefit. Here, we use whole‐genome CRISPR‐Cas9 knockout data to uncover an important role for Tuberous Sclerosis Complex 2 (TSC2) in determining tumor susceptibility to cytotoxic T lymphocyte (CTL) killing in human melanoma cells. TSC2‐depleted tumor cells had disrupted mTOR regulation following CTL attack, which was associated with enhanced cell death. Wild‐type tumor cells adapted to CTL attack by shifting their mTOR signaling balance toward increased mTORC2 activity, circumventing apoptosis, and necroptosis. TSC2 ablation strongly augmented tumor cell sensitivity to CTL attack in vitro and in vivo, suggesting one of its functions is to critically protect tumor cells. Mechanistically, TSC2 inactivation caused elevation of TRAIL receptor expression, cooperating with mTORC1‐S6 signaling to induce tumor cell death. Clinically, we found a negative correlation between TSC2 expression and TRAIL signaling in TCGA patient cohorts. Moreover, a lower TSC2 immune response signature was observed in melanomas from patients responding to immune checkpoint blockade. Our study uncovers a pivotal role for TSC2 in the cancer immune response by governing crosstalk between TSC2‐mTOR and TRAIL signaling, aiding future therapeutic exploration of this pathway in immuno‐oncology.
Downregulated ETV4 inhibits the proliferation, migration, and invasion of trophoblast cells in preeclampsia
Authors: Jie Qiuling , Chen Lijun , Liang Jiangying , Yang Xiaohui , Sun Fei , Ma Yanlin
Published: January 2023

In brief

Preeclampsia is a pregnancy complication that can lead to severe adverse maternal and fetal outcomes, but the mechanisms underlying the development of preeclampsia are not fully understood. This study shows that ETV4 plays an essential role in the proliferation, invasion, and migration of trophoblast cells by regulating MMP-2 and MMP-9 and is involved in the pathogenesis of preeclampsia.

Preeclampsia (PE) is a pregnancy complication that can lead to severe adverse maternal and fetal outcomes. However, the mechanisms underlying the development of PE are not fully understood. ETS Variant Transcription Factor 4 (ETV4) plays an important role in cell proliferation, migration, and invasion. In this study, we aimed to explore the potential function of ETV4 in placental trophoblast cells. We analyzed the expression and location of ETV4 in PE and uncomplicated placental tissues using RT-qPCR, Western blotting, immunohistochemistry, and immunofluorescence staining. The results showed that both the mRNA and protein levels of ETV4 were markedly decreased in PE placental tissues compared with placental tissues from women with uncomplicated pregnancies (P < 0.05). Then, the effects of ETV4 on HTR-8/SVneo and Bewo cell proliferation, migration, and invasion were evaluated by MTT, 5-ethynyl-2-deoxyuridine (EdU), wound healing, and Transwell assays, respectively. The results showed that ETV4 knockdown inhibited both HTR-8/SVneo and Bewo cell proliferation, migration, and invasion (P < 0.05). Conversely, overexpression of ETV4 promoted both HTR-8/SVneo and Bewo cell proliferation, migration, and invasion (P < 0.05). We then measured the expression of MMP-2 and MMP-9 in HTR8/SVneo cells. We found that ETV4 knockdown decreased the mRNA and protein expression of MMP-2 and MMP-9, while ETV4 overexpression increased MMP-2 and MMP-9 mRNA and protein expression (P < 0.05). In conclusion, ETV4 plays an essential role in the proliferation, invasion, and migration of trophoblast cells by regulating MMP-2 and MMP-9. Our findings provide novel insight into the mechanisms underlying the occurrence of PE.
Manejo de la mola hidatiforme. Reporte de un caso
Authors: Cuaresma-González María , Barrero-Real Laura , García-García Elena , Pérez-Gallego Lucía , Gobernado-Tejedor Julio Alberto , Ibáñez-Nieto Marta
Published: January 2023

Resumen
Introducción. La mola hidatiforme es un tipo de enfermedad trofoblástica gestacional que se presenta como resultado de la fertilización anormal de un ovocito y que ocasiona síntomas inespecíficos como amenorrea, metrorragia y aumento del tamaño del útero. Aunque infrecuentes, sus síntomas más característicos incluyen hiperémesis, preeclampsia de inicio temprano, anemia y distrés respiratorio.
Presentación del caso. Mujer marroquí de 47 años que consultó al servicio de urgencias del Hospital Clínico Universitario de Valladolid debido a que había presentado tos y vómitos por un mes. La paciente refirió haber sufrido epigastralgia y amenorrea por dos meses, así como escaso sangrado vaginal en los últimos dos días. Teniendo en cuenta que la paciente dio positivo en una prueba de embarazo, que en la ecografía transvaginal se observó una masa intrauterina heterogénea de 124x120mm, que no se reportaron hallazgos anormales en la ecografía Doppler y que sus niveles séricos de βhCG alcanzaron un valor de 772.110 mUI/mL, se sospechó un diagnóstico de mola hidatiforme. Una vez informada sobre las posibles alternativas terapéuticas, la paciente decidió someterse a una histerectomía total, pues refirió que ya había cumplido su deseo de ser madre. Luego de realizar procedimiento, la condición clínica de la paciente mejoró; además, el informe de patología de la masa permitió confirmar el diagnóstico de mola hidatiforme parcial.
Conclusiones. El diagnóstico temprano de la mola hidatiforme es de gran importancia para ofrecer un tratamiento adecuado y, de esta forma, mejorar el pronóstico de estas pacientes. Por tanto, a pesar de su baja incidencia y sus manifestaciones clínicas inespecíficas, se debe considerar como diagnóstico diferencial de las metrorragias del primer trimestre.
Sources of conflicts in the execution of projects in companies of the oil sector in the Eastern Coast of the Lake of Zulia state
Authors: González-Quintero Emmanuel José , Rondón-Ríos Melissa Carolina
Published: January 2023

The objective of the investigation was to describe the sources of conflicts in the execution of projects in companies of the oil sector in the Eastern Coast of the Lake of Zulia state. The type of research was descriptive, with a non-experimental field design. The population was made up of 22 subjects who hold the positions of Managers, Leaders and Project Engineers. The data collection technique used was the survey, subjected to a validation process by the judgment of seven experts in the area, and reliability was determined by means of the Alpha-Cronbach Coefficient, which was 0.92, being very high reliability. Subsequently, descriptive and inferential statistics were used by obtaining measures of central tendency and variability, allowing the corresponding analysis and discussion of results to be generated. As a proposal, the strategic guideline was generated for the identification of the sources of conflicts in the execution of projects.
Role of Ocean-Atmosphere Interface in Annual and Semiannual SST Cycles in the Indian Ocean
Authors: De Oliveira Carvalho-Junior Oldemar
Published: January 2023

A long-term analysis of temperature can be used to describe the main mechanisms that operate at the surface of the ocean. The average sea surface temperature (SST) contour plots for the Indian Ocean are produced based on the World Ocean Atlas Data Set (1994). SST, together with the independent variables wind (Wx, zonal component of pseudo-stress wind and Wy, meridional component of pseudo-stress wind), net-down-fresh-water-flow (NDFF), and Ekman pumping, are included in a multiple regression analysis to define the relative importance of each one of these variables in the physical processes at the surface of the Indian Ocean. The NDFF data set is based on COADS (Comprehensive Ocean-Atmosphere Data Set). The wind data is obtained from the Florida State University (FSU). The harmonic terms of the variables are calculated, which is considered to be stationary and expressed by a Fourier series as a cosine function. The harmonic terms are multiplied by the maximum amplitude of the variables and then added to their mean annual values. The isotherms are mainly meridional along the western boundary, but zonal in the southern Indian Ocean. The annual component is seen to have a maximum in July, Summer Monsoon (SW Monsoon) and a minimum in January, during the Winter Monsoon (NE Monsoon). The amplitude of the semiannual component is smaller, with two maxima in May and October and two minima in February and August. The small magnitude of these residuals errors is an indication that the temperature variability during this period and for this area can be explained reasonably well by the two harmonic terms. In the Arabian Sea, the final regression equations for SST variability show that it is mainly affected by the Wx, Ekman pumping and NDFF. For most of the areas of the Bay of Bengal, as well as for most of the locations in the southern tropical Indian Ocean, the entered independent variables can explain SST. Two components fit to observation can be used to predict SST together with the regression equations. Although harmonic analysis can be used to study SST variability, a multiple regression analysis is required to identify and quantify the variables related to areas of large annual and semiannual variability. Different techniques are therefore used together to provide more reliable results in SST configuration in the Indian Ocean.
Seismic properties of the permafrost layer using the HVSR method in Seymour-Marambio Island, Antarctica
Authors: Vargas Jimenez Carlos Alberto , Solano Juan M. , Gulisano Adriana M. , Santillana Sergio , Casallas Edwin A.
Published: January 2023

Authors have calculated the H/V spectral ratios using seismic-noise recordings in the uppermost layers north of the Seymour-Marambio Island, Antarctic. Sixty-seven seismic site-response measurements near and far from the Argentinean Marambio Base runway suggest geotechnical works on the uppermost sedimentary layers due to maintenance, landing, and taxi of large loads and aircraft during decades could contribute to changes in their seismic dynamic response. Two horizontal images of Vp, Vs, and Vp/ Vs ratios at 1.0 m and 35.0 m depth show lateral variations in the permafrost properties. Authors interpret that permafrost is emplaced in rocks with different porosities and contrasting fluids saturation at those depths. In shallow strata, the saturation of gases affects mainly the elastic properties. In deeper strata, where the location of water reservoirs is detected, the primary mechanism of seismic dissipation is anelastic.
Life on Mars (LoMars): History, advances, current research, and perspectives
Authors: Ali Arshad , Shahid Muhammad S. , Jabeen Iffat , El-Ghali Mohamed A.K.
Published: January 2023

A quest for life on Mars (LoMars) started in the early 1960s when the most prestigious scientific journals published several research articles. According to Elsevier’s Scopus database, the rise in annual literature production started in the late 1990s, most likely associated with the launch of the National Aeronautics and Space Administration’s (NASA) first rover, Sojourner, in 1996. The number of articles on Mars will likely continue to rise sharply, given that the launch and landing of the Mars 2020 Perseverance Rover are critical to discovering and understanding the present or past life on the planet. Thus far, the USA has dominated in the number of citations and collaborations related to Mars research, given its facilities equipped with relevant infrastructure and researchers’ capacity to explore the Solar System beyond Earth. Most of these frequently cited papers report observational and theoretical research results. However, a highly cited article is based on analytical studies of a unique Martian meteorite (i.e., Allan Hills 84001) found in Antarctica. It is expected that the future sample return mission associated with the Perseverance Rover caching system could increase the LoMars research exponentially in the coming decades if Martian samples are successfully brought to Earth. Based on the total number of publications on LoMars, the most influential institute, the author, and the journal are Caltech, C.P. McKay, and Icarus, respectively. Both the institute and the author are directly affiliated with NASA, indicating the leadership offered by the organization in LoMars research.
El diario de Mohamed Chukri: nocturbanidad y duelo
Authors: Mesmoudi Mehdi
Published: January 2023

Mohamed Chukri (1935-2003) es un escritor mediterráneo clave en cuanto al género autobiográfico se refiere. Su trilogía autobiográfica y otros escritos han sido traducidos al inglés, francés, y español, lo cual ha hecho posible una amplia recepción de su obra por parte de la crítica literaria internacional. En virtud de lo anterior, este trabajo explora el diario de Mohamed Chukri como una práctica escritural asociada a una doble dimensión decadente: por un lado la nocturbanidad orientada a la práctica de un flâneur a la deriva y, por otro, el duelo como una puesta en escena fallida. Esta odisea es imposible sin la dupla formada con el escritor estadounidense Tennessee Williams, con quien estableció un diálogo recíproco, sus retratos como de otras figuras presentes en este diario son un contexto histórico-político de Marruecos y Tánger de posguerra; es decir, la dimensión beat y contracultural del discurso chukriano.