bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Probability Model for LncRNA–Disease Association Prediction Based on the Naïve Bayesian Classifier
Authors: Yu Jingwen , Ping Pengyao , Wang Lei , Kuang Linai , Li Xueyong , Wu Zhelun
Published: July 2018

An increasing number of studies have indicated that long-non-coding RNAs (lncRNAs) play crucial roles in biological processes, complex disease diagnoses, prognoses, and treatments. However, experimentally validated associations between lncRNAs and diseases are still very limited. Recently, computational models have been developed to discover potential associations between lncRNAs and diseases by integrating multiple heterogeneous biological data; this has become a hot topic in biological research. In this article, we constructed a global tripartite network by integrating a variety of biological information including miRNA–disease, miRNA–lncRNA, and lncRNA–disease associations and interactions. Then, we constructed a global quadruple network by appending gene–lncRNA interaction, gene–disease association, and gene–miRNA interaction networks to the global tripartite network. Subsequently, based on these two global networks, a novel approach was proposed based on the naïve Bayesian classifier to predict potential lncRNA–disease associations (NBCLDA). Comparing with the state-of-the-art methods, our new method does not entirely rely on known lncRNA–disease associations, and can achieve a reliable performance with effective area under ROC curve (AUCs)in leave-one-out cross validation. Moreover, in order to further estimate the performance of NBCLDA, case studies of colorectal cancer, prostate cancer, and glioma were implemented in this paper, and the simulation results demonstrated that NBCLDA can be an excellent tool for biomedical research in the future.
An Essential Tool for Natural Heritage Management: The Geomorphological Map of Valderejo Natural Park
Authors: González-Amuchastegui María José , Serrano Enrique
Published: July 2018

This study supports the usefulness of geomorphological mapping as a tool for gaining an understanding of the landscape and assessing natural heritage. Mapping provides an essentially scientific document with great potential for the diffusion of geomorphological knowledge in that it provides a guide to the user of natural protected areas as well as serving as a tool for its management regarding geotourist itineraries, geodiversity, and geomorphosites. The example of the Valderejo Natural Park is presented, which is located in Álava (Spain) and whose geomorphology has been mapped following a methodology based on fieldwork, desktop work, and the use of Geographic Information Systems. The map’s applications are presented in the areas of tourism, geotourist maps, and for the assessment of natural heritage, geodiversity, and geomorphosites.
Vulnerability and Site Effects in Earthquake Disasters in Armenia (Colombia). I—Site Effects
Authors: Chávez-García Francisco J. , Monsalve Jaramillo Hugo , Gómez Cano Marisol , Vila Ortega José J.
Published: July 2018

The city of Armenia, Colombia has been repeatedly subjected to moderate magnitude earthquakes. Damage in that city for the 1999 (Mw6.2) event was disproportionate (maximum observed EMS-92 intensity of IX), even considering the small epicentral distance (18 km). Two main factors have been invoked: Site effects and vulnerability of the building stock. We re-analyze available data on site effects, including: Records of aftershocks of the 1999 event, ambient noise records obtained using standalone stations, array records of ambient noise, and available shear wave profiles from seismic cone measurements. We estimate local amplification from spectral ratios of earthquake records relative to a reference site, the horizontal relative to the vertical component (HVSR, Horizontal-to-Vertical Spectral Ratios) of earthquakes and ambient noise records, and ratios of response spectra relative to a reference site or to simulated ground motion. These estimates are compared to amplification functions computed for 1D soil models, inverted from microtremor array observations. Our estimates of site effects for Armenia are therefore robust and bring together results previously available only in internal reports. We show that spectral ratios relative to a reference site may fail to estimate the amplification level. Site effects in Armenia are relatively homogeneous. Although site amplification is very significant and contributed to the observed damage, it does not account for the irregular damage distribution observed in 1999.
Suicide Risk among Immigrants and Ethnic Minorities: A Literature Overview
Authors: Forte Alberto , Trobia Federico , Gualtieri Flavia , Lamis Dorian A. , Cardamone Giuseppe , Giallonardo Vincenzo , Fiorillo Andrea , Girardi Paolo , Pompili Maurizio
Published: July 2018

Recent studies have demonstrated that immigrants and ethnic minorities may be at higher risk of suicidal behaviour as compared to the general population. We conducted a literature search to identify studies in English from 1980 to 2017 related to suicide risk among immigrants and ethnic minorities. Six hundred and seventy-eight reports were screened, and 43 articles were included in the qualitative synthesis of the review. Some studies reported lower rates of suicide attempts, while other findings suggested higher rates of suicidal behaviour and deaths among immigrants as compared to the native population. Also, a positive correlation was found between suicidal behaviour and specific countries of origin. Non-European immigrant women were at the highest risk for suicide attempts, a group which included young women of South Asian and black African origin. Risk factors among migrants and ethnic minorities were found to be: language barriers, worrying about family back home, and separation from family. The lack of information on health care system, loss of status, loss of social network, and acculturation were identified as possible triggers for suicidal behaviour. Overall, results suggest that specific migrant populations and ethnic minorities present a higher risk of suicidal behaviour than native populations, as well as a higher risk of death by suicide.
Constructing the Elements of the “Recovery in” Model through Positive Assessments during Mental Health Home Visits
Authors: Raitakari Suvi , Holmberg Suvi , Juhila Kirsi , Räsänen Jenni-Mari
Published: July 2018

The study provides a categorization of the different elements of the “recovery in” model (RIM). The objective is to analyze elements of RIM in positive assessments during home visit interactions. RIM approaches mental illness as a long-term condition that people live with in their daily lives in their communities. The model emphasizes the rights of all citizens to be full members of their communities regardless of their mental health problems or other difficulties. Positive assessments are professionals’ encouraging evaluations of the activities, situations, or inner conditions expressed by the clients. They are essential in creating supportive professional-client communication. The data analyzed in this study consists of 17 audio-recorded home visits of 10 different clients. Home visits were provided by a mental health floating support service in 2012. The data was analyzed using coding and ethnomethodological interaction research (EIR). As a result RIM is divided into two upper-categories: “Encouraging Doing the Right Thing” and “Encouraging the Right Kind of Personal Growth”. These categories include a wide spectrum of elements that are relevant for the client’s agency in the community. The elements embed the client’s performance in everyday routines and the client’s progress in becoming a skillful, knowledgeable, and involved agent in the community. The categorization of the elements of RIM could be used in educating practitioners to identify and operationalize RIM in mental health home visits.
Prevalence of Vaccine Type Infections in Vaccinated and Non-Vaccinated Young Women: HPV-IMPACT, a Self-Sampling Study
Authors: Jeannot Emilien , Viviano Manuella , De Pree Charlotte , Amadane Mona , Kabengele Emmanuel , Vassilakos Pierre , Petignat Patrick
Published: July 2018

Background: The human papillomavirus (HPV) vaccination program for young girls aged 11–26 years was introduced in Switzerland in 2008. The objective of this study was to evaluate the prevalence of high- and low-risk HPV in a population of undergraduate students using self-sampling for monitoring the HPV vaccination program’s effect. Methods: Undergraduate women aged between 18–31 years, attending the Medical School and University of Applied Sciences in Geneva, were invited to participate in the study. Included women were asked to perform vaginal self-sampling for HPV testing using a dry cotton swab. Results: A total of 409 students participated in the study—aged 18–31 years—of which 69% of the participants were vaccinated with Gardasil HPV vaccine and 31% did not received the vaccine. About HPV prevalence, 7.2% of unvaccinated women were HPV 16 or 18 positive, while 1.1% of vaccinated women were infected by HPV 16 or 18 (p < 0.01). Prevalence of HPV 6 and 11 was 8.3% in non-vaccinated women versus 2.1% in vaccinated women (p < 0.02). We observed no cross-protection for the other HPV genotypes of a low- and high-risk strain. Conclusions: Prevalence of HPV 6/11/16/18 was lower in vaccinated women versus unvaccinated women. Continued assessment of HPV vaccine effectiveness in real population is needed.
Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data
Authors: Pickart Loren , Margolina Anna
Published: July 2018

The human peptide GHK (glycyl-l-histidyl-l-lysine) has multiple biological actions, all of which, according to our current knowledge, appear to be health positive. It stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and glycosaminoglycan synthesis, as well as supports the function of dermal fibroblasts. GHK’s ability to improve tissue repair has been demonstrated for skin, lung connective tissue, boney tissue, liver, and stomach lining. GHK has also been found to possess powerful cell protective actions, such as multiple anti-cancer activities and anti-inflammatory actions, lung protection and restoration of chronic obstructive pulmonary disease (COPD) fibroblasts, suppression of molecules thought to accelerate the diseases of aging such as NFκB, anti-anxiety, anti-pain and anti-aggression activities, DNA repair, and activation of cell cleansing via the proteasome system. Recent genetic data may explain such diverse protective and healing actions of one molecule, revealing multiple biochemical pathways regulated by GHK.
Antileishmanial Activity of Amphotericin B-loaded-PLGA Nanoparticles: An Overview
Authors: Palma Ernesto , Pasqua Antonella , Gagliardi Agnese , Britti Domenico , Fresta Massimo , Cosco Donato
Published: July 2018

In recent decades, nanotechnology has made phenomenal strides in the pharmaceutical field, favouring the improvement of the biopharmaceutical properties of many active compounds. Many liposome-based formulations containing antitumor, antioxidant and antifungal compounds are presently on the market and are used daily (for example Doxil®/Caelyx® and Ambisome®). Polymeric nanoparticles have also been used to entrap many active compounds with the aim of improving their pharmacological activity, bioavailability and plasmatic half-life while decreasing their side effects. The modulation of the structural/morphological properties of nanoparticles allows us to influence various technological parameters, such as the loading capacity and/or the release profile of the encapsulated drug(s). Amongst the biocompatible polymers, poly(D,L-lactide) (PLA), poly(D,L-glycolide) (PLG) and their co-polymers poly(lactide-co-glycolide) (PLGA) are the most frequently employed due to their approval by the FDA for human use. The aim of this review is to provide a description of the foremost recent investigations based on the encapsulation of amphotericin B in PLGA nanoparticles, in order to furnish an overview of the technological properties of novel colloidal formulations useful in the treatment of Leishmaniasis. The pharmacological efficacy of the drug after nanoencapsulation will be compared to the commercial formulations of the drug (i.e., Fungizone®, Ambisome®, Amphocil® and Abelcet®).
Candidemia in an intensive care unit
Authors: Adukauskienė Dalia , Kinderytė Aida , Dambrauskienė Asta , Vitkauskienė Astra
Published: July 2018

Candidemia is becoming more actual because of better survival of even critically ill patients, wide use of antimicrobials, and increased numbers of invasive procedures and manipulations. Diagnosis of candidemia remains complicated, and costs of treatment and mortality rates are increasing. Objective. To evaluate the pathogens of candidemia, risk factors and their influence on outcome. Material and methods. Data of 41 patients with positive blood culture for Candida spp., who were treated in the intensive care units at the Hospital of Kaunas University of Medicine, were analyzed retrospectively. Results. Candidemia was caused by Candida albicans (C. albicans) in 48.8% (n=20) of patients and by non-albicans Candida in 51.2% (n=21) of patients. The main cause of candidemia was C. albicans in 2004 (83.3%, n=5), but in 2005 (63.6%, n=7), in 2006 (57.1%, n=4), and in 2007 (52.9%, n=9), the main cause was non-albicans Candida spp. The number of candidemia cases caused by C. albicans was decreased in 2005, 2006, and 2007 as compared with 2004, and the number of candidemia caused by non-albicans Candida spp. was decreased, respectively (P<0.05). More than 65% (n=34) of patients had severe disease (P<0.05). Lethal outcome was recorded in 58.5% of patients with candidemia. Mechanical ventilation was used in 76.9% (n=20) and urinary bladder catheter in 72.1% (n=19) of non-survivors and in 23.1% (n=6) and 26.9% (n=7) of survivors, respectively (P<0.05). Conclusions. There is an increase in the prevalence of candidemia in the intensive care units during the 4-year period; half of candidemia cases were caused by non-albicans Candida spp., and patients with candidemia caused by non-albicans Candida spp. are at higher risk of mortality. Therefore, for the empirical treatment of septic conditions in an intensive care unit, when invasive fungal infection is suspected, we recommend using an antifungal agent of non-azole class until a pathogen of candidemia is determined. Severe disease is evaluated as a risk factor for candidemia. Patients with oncological diseases are at significantly higher risk for candidemia caused by non-albicans Candida spp. Use of mechanical ventilation and urinary bladder catheter is a risk factor for lethal outcome.
Investigation of contribution of individual constituents to antioxidant activity in herbal drugs using postcolumn HPLC method
Authors: Raudonis Raimondas , Jakštas Valdas , Burdulis Deividas , Benetis Raimondas , Janulis Valdimaras
Published: July 2018

The most important attention is paid to the search of natural antioxidants and their evaluation in medicinal and food raw materials of plant origin. A number of plants, their extracts, food products, and medicinal preparations appear to be the objects of scientific research. Effectiveness and informative character of research, undoubtedly, depend on relevance, sensitivity, and efficiency of the methods chosen. The aim of this work was to develop and validate the postcolumn high-performance liquid chromatography (HPLC)-DPPH method as well as its application in the evaluation of antioxidant activity of known and unknown compounds scavenging free radicals and existing in medicinal plant raw materials. HPLC-separated compounds were identified at the wavelength of 275 nm, and then the mobile phase with analytes flowed through a mixing tee to the reaction coil, where DPPH reagent solution was supplied. The solution flow rate was 0.4 mL/min. The reaction coil was connected with UV/VIS type detector, which measured absorption of flowing solution at the wavelength of 520 nm. It was determined that vitexin rhamnoside, the dominant compound in the leaves of Crataegus monogyna, was not a significant radical scavenger. The most active antioxidant in the leaves and flowers of Crataegus monogyna was chlorogenic acid. The most active antioxidant in Origanum vulgare raw material was rosmarinic acid. Identified analytes in the extracts of Achillea millefolium that possessed radical-scavenging properties were chlorogenic acid, luteolin-7-Oglucoside, rutin, and luteolin.
Associations between schoolchildren’s educational load and health, and the day’s routine
Authors: Sketerskienė Rita , Šurkienė Genė , Žagminas Kęstutis
Published: July 2018

Objective. To estimate the associations between educational load and health, and elements of day’s routine among Lithuanian schoolchildren, attending classes of first stage of basic education curriculum. Material and methods. During 14–28 November, 2005, the study was performed in 108 secondary schools, providing basic secondary education in Lithuanian language. A total of 3744 schoolchildren and 1601 parents filled in an original, specially designed questionnaire. Results. More than two-thirds of the schoolchildren (69.2%) estimated their health as very good or good, and 19.2% indicated that they were not ill during the last year. Schoolchildren who reported educational load to be too high estimated their health worse (P<0.001), were ill more frequently (P<0.001), and due health disorders had to limit their regular activities. Educational load had an impact on schoolchildren’s well-being and relationships with parents. Elements of day’s routine depended on gender, grade, and place of residence. Less than one-third (32.8%) of schoolchildren reported 9–10-hour night’s sleep, 33.8% – spending 3 hours outdoors on workdays. Passive activities dominate during schoolchildren’s leisure time. More than half of schoolchildren (60.3%) spend 2–3 hours watching television, 30.7% – 2 or more hours working with computer on workdays. Conclusions. Too high educational load have a negative impact on schoolchildren’s health and well-being, relationships with parents. Schoolchildren with an adequate educational load follow recommendations of the day’s routine more frequently.
The risk of cancer among Lithuanian medical radiation workers in 1978–2004
Authors: Samerdokienė Vitalija , Atkočius Vydmantas , Valuckas Konstantinas
Published: July 2018

Objectives. To describe the cohort of Lithuanian medical radiation workers and to estimate the risk of cancer during 1978–2004. Methods. Analysis of cancer risk evaluation was done using the retrospective cohort method, an indirect standardization. The observed numbers of cancer cases were obtained from the National Cancer Registry. The expected numbers were based on the age- and gender-specific incidence rates for the general Lithuanian population in 5-year periods. The standardized incidence ratios and 95% confidence intervals (assuming that the incidence of cancer follows the Poisson distribution) were calculated. Results. During the follow-up of 1978–2004, 159 cases of cancer were observed. There was no increased overall cancer risk in men (SIR=0.92, 95% CI=0.62–1.33, based on 29 cases) and women (SIR=0.97, 95% CI=0.81–1.15, based on 130 cases). The risk of leukemia among men and women was insignificantly increased. Conclusions. During the follow-up period, the overall cancer risk among medical radiation workers was the same as in the general population of Lithuania
Recent Development of Genetic Code Expansion for Posttranslational Modification Studies
Authors: Chen Hao , Venkat Sumana , McGuire Paige , Gan Qinglei , Fan Chenguang
Published: July 2018

Nowadays advanced mass spectrometry techniques make the identification of protein posttranslational modifications (PTMs) much easier than ever before. A series of proteomic studies have demonstrated that large numbers of proteins in cells are modified by phosphorylation, acetylation and many other types of PTMs. However, only limited studies have been performed to validate or characterize those identified modification targets, mostly because PTMs are very dynamic, undergoing large changes in different growth stages or conditions. To overcome this issue, the genetic code expansion strategy has been introduced into PTM studies to genetically incorporate modified amino acids directly into desired positions of target proteins. Without using modifying enzymes, the genetic code expansion strategy could generate homogeneously modified proteins, thus providing powerful tools for PTM studies. In this review, we summarized recent development of genetic code expansion in PTM studies for research groups in this field.
Correction: Huang, H.W.; et al. Sinularin Selectively Kills Breast Cancer Cells Showing G2/M Arrest, Apoptosis, and Oxidative DNA Damage. Molecules 2018, 23, 849
Authors: Huang Hurng-Wern , Tang Jen-Yang , Ou-Yang Fu , Wang Hui-Ru , Guan Pei-Ying , Huang Chiung-Yao , Chen Chung-Yi , Hou Ming-Feng , Sheu Jyh-Horng , Chang Hsueh-Wei
Published: July 2018

The authors wish to make the following correction to their paper [1].[...]
Convenient Synthesis and Physiological Activities of Flavonoids in Coreopsis lanceolata L. Petals and Their Related Compounds
Authors: Nakabo Daisuke , Okano Yuka , Kandori Naomi , Satahira Taisei , Kataoka Naoya , Akamatsu Junpei , Okada Yoshiharu
Published: July 2018

Chalcones, flavanones, and flavonols, including 8-methoxybutin isolated from Coreopsis lanceolata L. petals, were successfully synthesized with total yields of 2–59% from O-methylpyrogallols using the Horner–Wadsworth–Emmons reaction as a key reaction. Aurones, including leptosidin, were also successfully synthesized with 5–36% total yields using the Aldol condensation reaction as a key reaction. Each chalcone, flavanone, flavonol, and aurone with the 3,4-dihydroxy groups in the B-ring showed high antioxidant activity. Additionally, each of the chalcones, flavanones, flavonols, and aurones with the 2,4-dihydroxy groups in the B-ring showed an excellent whitening ability.
Mechanism of Two-/Four-Electron Reduction of Nitroaromatics by Oxygen-Insensitive Nitroreductases: The Role of a Non-Enzymatic Reduction Step
Authors: Valiauga Benjaminas , Misevičienė Lina , Rich Michelle H. , Ackerley David F. , Šarlauskas Jonas , Čėnas Narimantas
Published: July 2018

Oxygen-insensitive NAD(P)H:nitroreductases (NR) reduce nitroaromatics (Ar-NO2) into hydroxylamines (Ar-NHOH) through nitroso (Ar-NO) intermediates. Ar-NO may be reduced both enzymatically and directly by reduced nicotinamide adenine dinucleotide or its phosphate NAD(P)H, however, it is unclear which process is predominant in catalysis of NRs. We found that E. coli NR-A (NfsA) oxidizes 2 mol of NADPH per mol of 2,4,6-trinitrotoluene (TNT) and 4 mol of NADPH per mol of tetryl. Addition of ascorbate, which reduces Ar-NO into Ar-NHOH, changes the stoichiometry NADPH/Ar-NO2 into 1:1 (TNT) and 2:1 (tetryl), and decreases the rate of NADPH oxidation. Ascorbate does not interfere with the oxidation of NADPH during reduction of quinones by NfsA. Our analysis of ascorbate inhibition patterns and both enzymatic and non-enzymatic reduction of nitrosobenzene suggests that direct reduction of Ar-NO by NADPH rather than enzymatic reduction is the predominant mechanism during nitroaromatic reduction.
Failure Characteristics and Mechanism of Nano-Modified Oil-Impregnated Paper Subjected to Repeated Impulse Voltage
Authors: Sun Potao , Sima Wenxia , Zhang Dingfei , Jiang Xiongwei , Zhang Huangjing , Yin Ze
Published: July 2018

Nano-modification is a prospective method for improving the electrical properties of transformer oil. In most situations, transformer oil combined with cellulose paper is used to construct an insulation system for power equipment, such as power transformers. However, the influence of nanoparticles on the electrical performance of oil-impregnated paper is still unclear. Therefore, in this paper, we identify the failure characteristics of both fresh and nano-modified oil/paper. Specifically, the accumulative failure characteristics of nano-oil-impregnated paper (NOIP) are experimentally determined. The space charge distribution and trap characteristics of fresh paper and NOIP were measured, and the effect of nanoparticles on the space charge behavior are then analyzed. Finally, we measure the microstructure of fresh paper and NOIP subjected to repeated impulses. The test results indicate that nano-titanium oxide (TiO2) particles have a limited effect on the breakdown voltage of NOIP. However, the particles can dramatically improve the resistant ability of NOIP against repeated impulses. For the NOIP with a nano-concentration of 0.25 g/L, the improvement reaches 62.5% compared with fresh paper. Under repeated applications of impulse voltages, the space charge density of NOIP is much lower than that of fresh paper. The deep trap density of NOIP is much higher than that of fresh OIP, whereas shallow trap density is relatively lower. Micropores are generated in paper insulation subjected to repeated impulses. The amount of the generated micropores in NOIP is lower than that in fresh paper. Nano-TiO2 particles suppress the accumulation of space charge in the oil paper insulation, which weakens the electric field distortion in the dielectric. However, nanoparticles reduce the accumulative damage caused by repeated impulses. The above two points are considered the main reasons to improve the resistant ability against repeated impulses.
The Effect of Food Unit Sizes and Meal Serving Occasions on Eating Behaviour Characteristics: Within Person Randomised Crossover Studies on Healthy Women
Authors: Langlet Billy , Tang Bach Mona , Odegi Dorothy , Fagerberg Petter , Ioakimidis Ioannis
Published: July 2018

Manipulating food properties and serving environment during a meal can significantly change food intake at group level. However, the evaluation of the usefulness of such manipulations requires an understanding of individual behavioural changes. Three studies were conducted to explore the effect of unit size and meal occasion on eating behaviour characteristics (food intake, meal duration, number of bites and chews). All studies used a randomised crossover design, with a one-week wash-out period, starting with a familiarisation meal, with the participation of healthy, normal weight females between the ages of 18–35 years. In Study 1 (n = 19) three cube sizes (0.5, 1.0 and 1.5 cm3) of vegetable hash and chicken were compared. In Study 2 (n = 18) mashed potatoes and mincemeat were compared to whole potatoes and meatballs. In Study 3 (n = 29) meals served at lunch time (11:00–13:00) were compared to identical meals served at dinner time (17:00–19:00). The largest food unit size lead to significantly increased meal duration in Study 2 (mean difference 0.9 min, 95% confidence interval (CI) 0.0–1.8), but not in Study 1 (mean difference 1 min, 95% CI 0.1–2.0). There was a significant increase in number of chews in the large unit size condition of both Study 1 (mean difference 88, 95% CI 12–158) and Study 2 (mean difference 95, 95% CI 12–179). Different serving occasions did not significantly change any of the eating behaviours measured. Except for number of bites in Study 2 (R2 = 0.60), most individuals maintained their eating behaviour relative to the group across unit sizes and serving occasions conditions (R2 > 0.75), which suggests single meal testing can provide information about the behavioural characteristics of individual eating styles under different conditions.
A Review on the Relationship between Tocotrienol and Alzheimer Disease
Authors: Chin Kok-Yong , Tay Shu Shen
Published: July 2018

Alzheimer’s disease (AD) is plaguing the aging population worldwide due to its tremendous health care and socioeconomic burden. Current treatment of AD only offers symptomatic relief to patients. Development of agents targeting specific pathologies of AD is very slow. Tocotrienol, a member of the vitamin E family, can tackle many aspects of AD, such as oxidative stress, mitochondrial dysfunction and abnormal cholesterol synthesis. This review summarizes the current evidence on the role of tocotrienol as a neuroprotective agent. Preclinical studies showed that tocotrienol could reduce oxidative stress by acting as a free-radical scavenger and promoter of mitochondrial function and cellular repair. It also prevented glutamate-induced neurotoxicity in the cells. Human epidemiological studies showed a significant inverse relationship between tocotrienol levels and the occurrence of AD. However, there is no clinical trial to support the claim that tocotrienol can delay or prevent the onset of AD. As a conclusion, tocotrienol has the potential to be developed as an AD-preventing agent but further studies are required to validate its efficacy in humans.
Bioavailability Enhancement of Poorly Water-Soluble Drugs via Nanocomposites: Formulation–Processing Aspects and Challenges
Authors: Bhakay Anagha , Rahman Mahbubur , Dave Rajesh N. , Bilgili Ecevit
Published: July 2018

Drug nanoparticles embedded in a dispersant matrix as a secondary phase, i.e., drug-laden nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and bioavailability of poorly water-soluble drugs. Drug nanoparticles are prepared by top-down, bottom-up, or combinative approaches in the form of nanosuspensions, which are subsequently dried to prepare drug-laden nanocomposites. In this comprehensive review paper, the term “nanocomposites” is used in a broad context to cover drug nanoparticle-laden intermediate products in the form of powders, cakes, and extrudates, which can be incorporated into final oral solid dosages via standard pharmaceutical unit operations, as well as drug nanoparticle-laden strip films. The objective of this paper is to review studies from 2012–2017 in the field of drug-laden nanocomposites. After a brief overview of the various approaches used for preparing drug nanoparticles, the review covers drying processes and dispersant formulations used for the production of drug-laden nanocomposites, as well as various characterization methods including quiescent and agitated redispersion tests. Traditional dispersants such as soluble polymers, surfactants, other water-soluble dispersants, and water-insoluble dispersants, as well as novel dispersants such as wet-milled superdisintegrants, are covered. They exhibit various functionalities such as drug nanoparticle stabilization, mitigation of aggregation, formation of nanocomposite matrix–film, wettability enhancement, and matrix erosion/disintegration. Major challenges such as nanoparticle aggregation and poor redispersibility that cause inferior dissolution performance of the drug-laden nanocomposites are highlighted. Literature data are analyzed in terms of usage frequency of various drying processes and dispersant classes. We provide some engineering considerations in comparing drying processes, which could account for some of the diverging trends in academia vs. industrial practice. Overall, this review provides rationale and guidance for drying process selection and robust nanocomposite formulation development, with insights into the roles of various classes of dispersants.
Self-Erasable Nanocone Antireflection Films Based on the Shape Memory Effect of Polyvinyl Alcohol (PVA) Polymers
Authors: Li Peng , Han Yu , Wang Wenxin , Chen Xinlong , Jin Peng , Liu Shengchun
Published: July 2018

Arrays of nanostructure that are capable of broadband antireflection and light trapping properties are implemented in photovoltaic and photonic devices. However, most of the existing antireflection films have been hindered by a complicated fabricated method and structurally rigid. Here, we report a simple preparation method for self-erasable nanocone antireflection films using the surface replication method. Arrays of nanocone with sub-100 nm surface features could be replicated easily on the shape memory polyvinyl alcohol (PVA) film, and are erased by thermal stimulation. The reflectivity of self-erasable antireflection film can be switched from the 4.5% to 0.6% averaged over the visible spectral range by controlling the temperature below or above 80 °C. Theoretical simulations have been demonstrated. The unique smart film is expected to be used to further extend the application of smart optical windows and digital screens.
On the Xiapu Ritual Manual Mani the Buddha of Light
Authors: Ma Xiaohe , Wang Chuan
Published: July 2018

This paper first introduces Mani the Buddha of Light—a collection of ritual manuals of the Religion of Light from Xiapu county, Fujian Province, China and Diagram of the Universe—a Manichaean painting produced in South China in the late 14th to early 15th century. It then gives a detailed description of Mani the Buddha of Light with some illustrations of Diagram of the Universe. This paper further compares Mani the Buddha of Light and Buddhist worship and repentance ritual to demonstrate that the former utilized the form of the latter. It also analyzes the similarities and differences between the pantheons of Mani the Buddha of Light and other Manichaean materials. Ultimately it discusses the hypothesis that many pieces of the original texts in Mani the Buddha of Light should have come into being during the 9th–11th centuries and have been handed down generation after generation because of the strong vitality of its rituals.
Sea Surface Monostatic and Bistatic EM Scattering Using SSA-1 and UAVSAR Data: Numerical Evaluation and Comparison Using Different Sea Spectra
Authors: Zheng Honglei , Khenchaf Ali , Wang Yunhua , Ghanmi Helmi , Zhang Yanmin , Zhao Chaofang
Published: July 2018

The microwave scatterometer is one of the most effective instruments in ocean remote sensing, which urges the need for some theoretical models to accurately estimate the scattering coefficient of the sea surface. For the simulation of the scattering from an ocean surface, the sea spectrum, or its inverse Fourier transform, autocorrelation function is essential. Currently, many sea spectral models have been proposed for describing sea waves. However, which spectrum should be adopted during electromagnetic (EM) computations? A systematic comparison of these models is needed to evaluate their accuracies. In this paper, we focus on numerical simulations of scattering from a rough sea surface in monostatic and bistatic configurations by using six different sea spectral models and the first-order small slope approximation (SSA-1). First, sea spectral models proposed by Elfouhaily et al., Hwang et al., Romeiser et al., Apel et al., Fung et al., and Pierson et al., are compared with each other from different points of view, e.g., the omnidirectional parts, the angular spreading functions, the autocorrelation functions, and the slope variances. We find that the spectra given by Elfouhaily and Hwang could reflect realistic wind sea waves more accurately. Then, the scattering coefficients are simulated in fully monostatic and bistatic configurations. Regarding the monostatic scattering, the results simulated using EM scattering models are compared with those obtained from the measured UAVSAR data in the L band and the empirical model CMOD5 in the C band. Comparisons are made for various incident angles, wind speeds, and wind directions. Meanwhile, special attention is paid to low to moderate incident angles. The comparisons show that, it is difficult to find one certain spectral model to simulate scattering coefficient accurately under all wind speeds or wind directions. Accurate estimations will be obtained using different methods according to different situations.
Knowledge and Behavior of Saudi College Athletes toward Energy and Sports Drinks with an Emphasis on Microbial Quality and Safety
Authors: Aljaloud Sulaiman Omar
Published: July 2018

The aim of this study was to assess the knowledge and behavior of university athletes in Saudi Arabia regarding energy drinks (EDs) and sports drinks (SDs). In addition, the microbiological quality of available local drinks was also assessed. The presence of total bacterial coliform count, Escherichia coli, Salmonella, and Staphylococcus aureus on these drinks was also determined. Of the 120 university athletes surveyed, 69 were currently using SDs, and 51 were using EDs. The study consisted of a 10-question survey assessing the athletes’ sociodemographic characteristics, personal habits, and SD- and ED-related knowledge and habits. With regard to the question about the primary reason for using EDs, n = 26 respondents (50.98%) reported that providing energy (speed, strength, and power) was the main reason for consuming these beverages. Conversely, n = 25 respondents (36.23%) believed that recovery from injury or illnesses was the main reason for the consumption of SDs. A majority of university athletes (n = 43, 62.32%) who used SDs believed that SDs were safe to use, while n = 22 respondents (43.14%) were unaware of any adverse health effects associated with the consumption of EDs. Of the total of 26 SDs and EDs tested, microbial contamination was present in only two products. Microbial levels and the total bacterial count for most of the samples were very low (<1 log CFU/mL). However, some drinks had a slightly higher microbial level, which could be harmful or cause spoilage with improper storage. Thus, our findings suggest that improvements in microbial quality are needed for these beverages.
Applying Data Mining to China’s Swine Farming Industry: A Compromise Perspective of Economic, Environmental and Overall Performances
Authors: Huang Diejun , Ma Qiuzhuo , Feng Liangyu , Wen Xiaowei , Li Hua
Published: July 2018

The economic and environmental performances of the swine farming industry have always resulted in heated discussions in developing countries. Exploring the relationship between these features and the producers’ overall performance is the focus of this paper. For constructing multi-objective features that include the above features, a compromise approach for optimization is taken into consideration. For classifying the overall performance into different levels and detecting the effect of economic and environmental features on such features, an iteration scheme is developed in which the overall performance is treated as a target label. By neglecting this target label, a k-means clustering method is then used to help predict the producer’s overall performance given their economic and environmental features. In data pre-processing, correlation analysis for feature selection shows that the producer’s pollution emission and received regulation intensity largely affect its overall performance, while profit is found to be negatively correlated with pollution emission as regulation intensity is neglected. The classification result derived from the Silhouette Coefficient shows that the data set can be efficiently split into different groups in terms of the producer’s overall performance. The average distance between the objects in the low-performance group is larger than that of the high-performance group. The threshold position between the two groups is found to be largely dependent on the features of pollution emission and regulation intensity. The clustering result obtained by the k-means method shows good effectiveness and efficiency in separating the objects into different groups based on various features other than the overall performance. In 2- and 3-cluster cases, the result also shows evidence of the impact of economic and environmental features on the clustering result. The cross-validation analysis under a set of randomly chosen splitting points shows an increasing out-of-sample prediction quality with increases in training sample size. As one of the by-products of this paper, the geographical distribution in the clustering result is found partially consistent with the official report from Chinas central government regarding advantageous regions within the industry. In addition to current research, the ease of using the knowledge obtained in this paper for transfer learning is discussed.
Potential Sources of Anthropogenic Copper Inputs to European Agricultural Soils
Authors: Panagos Panos , Ballabio Cristiano , Lugato Emanuele , Jones Arwyn , Borrelli Pasquale , Scarpa Simone , Orgiazzi Alberto , Montanarella Luca
Published: July 2018

In the European Union (EU), copper concentration in agricultural soil stems from anthropogenic activities and natural sources (soil and geology). This manuscript reports a statistical comparison of copper concentrations at different levels of administrative units, with a focus on agricultural areas. Anthropogenic sources of diffuse copper contamination include fungicidal treatments, liquid manure (mainly from pigs), sewage sludge, atmospheric deposition, mining activities, local industrial contamination and particles from car brakes. Sales of fungicides in the EU are around 158,000 tonnes annually, a large proportion of which are copper based and used extensively in vineyards and orchards. Around 10 million tonnes of sewage sludge is treated annually in the EU, and 40% of this (which has a high copper content) is used as fertilizer in agriculture. In the EU, 150 million pigs consume more than 6.2 million tonnes of copper through additives in their feed, and most of their liquid manure ends up in agricultural soil. These three sources (sales of fungicides, sewage sludge and copper consumption for pigs feed) depend much on local traditional farming practices. Recent research towards replacing copper spraying in vineyards and policy developments on applying sewage and controlling the feed given to pigs are expected to reduce copper accumulation in agricultural soil.
Dual Chains Competition under Two Recycling Modes Based on System Dynamics Method
Authors: Xue Renzheng , Zhang Fengbin , Tian Feng , Oloruntoba Richard , Miao Shidi
Published: July 2018

The fast-growing accumulation of electronic waste (e-waste) around the world is resulting in environmental pollution and adverse human health and, thus, has become a global area of concern. As the world’s second largest producer of e-waste, China suffers significant pollution from e-waste because of inefficient recycling and management. This paper is a comparative systems dynamics study of two big home appliance manufacturers in China: Haier (Haier Group of Qingdao, China) and Gree (Gree Electric Appliances Inc. of Zhuhai, China). We used systems dynamics modeling to examine and compare the impact of closed-loop supply chain recycling and remanufacturing strategies on the total revenue of the supply chain and market shares of both manufacturers. Results show that an increase in third party service coverage and increased environmental awareness enhanced the total revenue of supply chain. Retailers showed more enthusiasm for recycling through contract development with manufacturers, thus resulting in reduced time of payment in closed-loop supply chains. We also found that an improvement of the recycling mechanism of retailers results in an increase in the share of the supply chain market. Hence, we propose a better supply chain mode.
The Effects of Inter-Partner Trust on Third-Country Relocation of International Joint Ventures in China
Authors: Hwang Yong-Sik , Kim Kidong
Published: July 2018

This study explores how inter-partner trust in international joint ventures (IJV) affects third country relocation decisions as foreign partners face an uncertain business environment in China due to wage increases and competition from local companies intensifies. As the concept of third-country relocation is relatively new compared to other international business concepts, it is crucial to find a solid framework that can explain this phenomenon. A study of 232 Korean IJVs operating in China was used to assess the relationship between inter-partner trust and third-country relocation intention. Also, we measured moderating variables that strengthen (plant performance, asset specificity, coercive pressure) and weaken (mimetic pressure and normative pressure) the negative relationship between trust and third-country relocation intention. The main effect and interaction effects were significant in showing that inter-partner trust hinders decisions on IJV’s third-country relocation. In addition, the results show that trust and third-country relocation relationship interact with other moderating variables. In conclusion, our study suggests that foreign IJVs should explore various aspects such as inter-partner relationships and internal and institutional factors before making decisions on IJV relocation.
Development of an Index of Transport-User Vulnerability, and its Application in Enschede, The Netherlands
Authors: Glensor Kain
Published: July 2018

An index of accessibility-based vulnerability is created based on a definition of transport-user vulnerability regarding transport accessibility created for the EMPOWER project, in order to assess the project’s key performance indicator of the inclusion of vulnerable people in the project’s scheme. The objective of the index is to account for various individual vulnerability aspects, but also for the ‘multi-dimensionality’ of vulnerability, i.e. individuals may be vulnerable because of one specific aspect (e.g., disability), or they may be vulnerable because of multiple aspects which, if assessed in isolation, wouldn’t classify the individual as vulnerable. Users of the project scheme in the Dutch city of Enschede are surveyed on, inter alia, their vulnerability based on this definition, according to their income, mobility budget, physical mobility, age, gender, living situation, nation of birth, and education. According to individual questions, 1% to 54% (single parents and females, respectively) of respondents have some level of vulnerability. According to the index, 23–36% of respondents can be considered to be vulnerable. Suitably modified for local conditions, the index is relevant to cities, especially quickly developing cities where congestion reduction is or has been a priority, insofar as it offers a way of measuring and monitoring the vulnerability of the users of their transport system. Finally, steps to adapt the index to other settings (cities or countries) are discussed.
Flow Partitioning Modelling Using High-Resolution Isotopic and Electrical Conductivity Data
Authors: Mosquera Giovanny M. , Segura Catalina , Crespo Patricio
Published: July 2018

Water-stable isotopic (WSI) data are widely used in hydrological modelling investigations. However, the long-term monitoring of these tracers at high-temporal resolution (sub-hourly) remains challenging due to technical and financial limitations. Thus, alternative tracers that allow continuous high-frequency monitoring for identifying fast-occurring hydrological processes via numerical simulations are needed. We used a flexible numerical flow-partitioning model (TraSPAN) that simulates tracer mass balance and water flux response to investigate the relative contributions of event (new) and pre-event (old) water fractions to total runoff. We tested four TraSPAN structures that represent different hydrological functioning to simulate storm flow partitioning for an event in a headwater forested temperate catchment in Western, Oregon, USA using four-hour WSI and 0.25-h electrical conductivity (EC) data. Our results showed strong fits of the water flux and tracer signals and a remarkable level of agreement of flow partitioning proportions and overall process-based hydrological understanding when the model was calibrated using either tracer. In both cases, the best model of the rainstorm event indicated that the proportion of effective precipitation routed as event water varies over time and that water is stored and routed through two reservoir pairs for event and pre-event. Our results provide great promise for the use of sub-hourly monitored EC as an alternative tracer to WSI in hydrological modelling applications that require long-term high-resolution data to investigate non-stationarities in hydrological systems.