bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH FOOD ESTATE DI DESA TAHAI BARU TERHADAP PERTUMBUHAN EKONOMI DI KABUPATEN PULANG PISAU
Authors: SN Triwid , Krisdayanti Lia , Irkamna Siti Ana , Veronika Nur
Published: January 2024

Afandi, A.G dan Soesatyo, Y. 2014. Pengaruh Industri Pengoahan, Perdagangan, Hotel, dan Restoran, dan Pertanian Terhadap PRODUK DOMESTIK REGIONAL BRUTO Kabupaten Mojokerto, (Online), (https://jurnalmahasiswa.unesa.ac.id/index.php/jupe/article/download/9348/9263, diakses 12 April 2019)
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Andy, P. dan Ady S. Pengaruh Sektor Basis dan Non Basis Terhadap Pertumbuhan Ekonomi di Kabupaten Pasuruan. (online),  (https://jurnalmahasiswa.unesa.ac.id/index.php/jupe/article/download/16900/15356), diakses 13 Maret 2019
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Prasetyo, P.E. 2009. Fundamental Makro Ekonomi. Betta Offset: Yogyakarta
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Purnami, N.M.S. dan Saskara, I.A.N. 2016. Analisis pengaruh pendidikan dan kontribusi sektor pertanian terhadap pertumbuhan ekonomi serta jumlah penduduk miskin, (online), Vol. 5, No. 11,  (https://ojs.unud.ac.id/index.php/eep/article/download/24082/16077, diakses 12 April 2019)
Rizieq, R. 2008. Analisis Keterkaitan Sektor Pertanian Dengan Sektor-Sektor Lainnya Dalam Perekonomian Kalimantan Barat. (online), Vol. 5, No. 1, (https://www.academia.edu/6544065/Analisis_KETERKAITAN_SEKTOR_PERTANIAN_DENGAN_SEKTOR-SEKTOR_LAINNYA_DALA_PEREKONOMIAN_KALIMANTAN_BARAT_1, diakses 12 April 2019
Saragih, B. 2010. Paradigma Baru Pembangunan Ekonomi Berbasis Pertanian. IPB Press :Bogor https://mmc.kalteng.go.id/berita/read/30570/mentan-lakukan-penanaman-perdana-pada-areal-food-estate-di-desa-tahai-baru-kab-pulang-pisau
https://www.borneonews.co.id/berita/183027-menteri-pertanian-hadiri-tanam-perdana-food-estate-di-desa-tahai-baru
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KONTRIBUSI MASYARAKAT MUSLIM TERHADAP KEGIATAN KEAGAMAAN DI DESA LAHEI MANGKUTUP
Authors: Muliansyah Ainol , Janah Anisa Minal , Munika Masti , Bahraini Nurul , Wilujeng Rani
Published: January 2024

Partisipasi dapat diartikan sebagai keterlibatan baik pikiran, perasaan, dan fisik yang bertujuan untuk memberikan sumbangan kepada kelompok dalam usaha mencapai tujuan yang diinginkan terhadap kegiatan yang diadakan. Metode penelitian yang digunakan adalah penelitian deskriptif dengan pendekatan kualitatif. Penelitian ini dilakukan di Desa Lahei Mangkutup Kecamatan Mantangai kabupaten Kapuas Provinsi Kalimantan Tengah. Sumber data yang digunakan sumber data primer. Subjek dalam penelitian ini berjumlah dua orang yang terdiri dari pengurus masjid, dan Kepala Desa Lahei Mangkutup. Hasil dari penelitian ditemukan bahwa masyarkat masih minim kesadaran akan keikutsertaan terhadap kegiatan keagaamaan salah satu contoh yang bisa menjadi tolak ukur adalah ketika mahasiswa melakukan kegiatan perihal pemberian materi serta praktek tentang fardhu kifayah masyarakat setempat sudah di berikan pengumuman tentang pelaksanaan kegiatan tersebut baik secara lisan mau secara tertulis. Walaupun demikian tetapi masyarakat masih belum sadar dan berkeinginan untuk hadir dalam kegiatan tersebut. Hal itu dapat dibuktikan melaui cerita dari beberapa masyrakat setempat salah satunya seperti yang di sampaikan oleh salah satu pengerus masjid dan didapatkan bahwa masih belum kesadaran masyarakat akan kegiatan tersebut, padahal di desa tersebut sangat dibutuhkan masyarakat yang paham dan mengerti tentang pelaksanaan fardhu kifayah.
Le plan d’intervention influence-t-il l’implication des parents auprès des élèves en difficulté ? Étude comparative selon les perspectives des parents
Authors: Arapi Enkeleda , Tremblay Philippe , Larivée Serge J.
Published: January 2024

The individualized education plan is a pedagogical tool designed to support the educational progress of pupils with difficulties. To be relevant, the implementation of the intervention plan must involve the parents. The objective of this paper is to compare the forms of parental involvement with primary school pupils with and without an intervention plan. A comparative quantitative and qualitative analysis is carried out on the dimensions of parental involvement and parents’ perceptions of the school-family-community relationship with 108 parents. The results indicate that the intervention plan does not bring significant differences in the forms of parental implication.
Les pratiques de gestion de classe des enseignants : efficacité perçue par les élèves présentant des difficultés comportementales
Authors: Bernier Vincent , Gaudreau Nancy , Massé Line
Published: January 2024

This article discusses the perceptions of students with emotional and behavioral difficulties (EBD) regarding the effectiveness of teachers’ classroom management practices. The interviews with fourteen PDC students enrolled in secondary school special class were analyzed using a qualitative thematic analysis approach. Based on the model of the five components of classroom management, the results offer an unprecedented perspective on classroom management and reveal a large inventory of practices perceived effective by participants to manage the classroom. They also reveal that the type of school attended and attitudes towards it particularly influence their perceptions. Finally, the perceptions of students with EBD are quite consistent with the practices recommended by research in the field.
Mise à l’épreuve d’un modèle interactionniste d’enseignement explicite des stratégies d’écriture
Authors: Falardeau Erick , Lord Marie-Andrée , Sauvaire Marion
Published: January 2024

Our research aims to build an interactionist model of explicit teaching of writing strategies for the primary and secondary levels adapted to Quebecois programs. The objective of this contribution is to present this model, implementation results, as well as the limits inherent in implementing explicit teaching on a large scale, particularly in the field of writing. Starting with a critique of behaviourist models of explicit teaching, we show how numerous researchers have adapted this pedagogical model to competency-based approaches, anchoring their work in cognitivist and socioconstructivist theories. The results obtained through our experimentations bring forward a reflection on the conditions that can facilitate the successful implementation of explicit teaching.
La planification dans l’action : les trois actions du personnel enseignant pour planifier une activité maker
Authors: Ciocca Jean-Luc , Cotnam-Kappel Megan
Published: January 2024

The article explores how teachers in francophone Ontarian schools conceptualize the planning of a Maker activity. Anchored in the do-it-yourself tradition, the unprecedented enthusiasm in education for this type of activity raises certain planning challenges and issues. The results of our qualitative analyses of interviews with two teachers (6th grade and 11th grade technical) underscore that teachers undertake three actions when planning a Maker activity: 1) create a Maker community spirit; 2) implement a Maker mentality through actions; and 3) adopt a planning-in-action approach. Our research underscores that a form of planning that we define as planning-in-action seems specific to Maker activities in a classroom at the primary or secondary level.
Analyse des savoirs mobilisés par des stagiaires en enseignement pour évaluer leurs élèves
Authors: Monney Nicole , Simard-Côté Alexandra , Smith Jennifer , Gagné Andréanne
Published: January 2024

This paper presents the results of a qualitative-interpretative study on the mobilization of assessment knowledge of five teacher candidates. The data was collected by the conduct of 10 in-class observations and 10 self-confrontation interviews. Based on the analysis of the results, teacher candidates primarily face challenges associated with knowledge of learning design and targeting learning objectives. As a result, the assessment activities are only carried out at the end of each lesson to confirm what has been learned. This article concludes by proposing a model that ranks the different types of assessment knowledge while proposing accompaniment strategies destined to teacher candidate supervisors.
Rencontre entre l’enseignant de deuxième carrière et son établissement scolaire : un mariage sans idylle
Authors: Coppe Thibault , März Virginie , Raemdonck Isabel
Published: January 2024

This contribution documents the professional integration of novice second-career teachers working in technical and vocational schools. We studied the experiences of this particular population of teachers through a qualitative study design with seven participants. The results highlight the harshness, difficulty, and complexity of this process. They experience institutional, organizational, and individual difficulties. In particular, the familiarization with the school as a new workplace is experienced as a complex process. The conclusions of the study provide insights on the consequences of the legal framework regulating access for second-career teachers to the teaching profession and the necessary training and support for these kinds of teachers.
Performance organisationnelle : le rôle du sentiment d’efficacité personnelle des enseignants
Authors: Levasseur Alice , Clément Louise
Published: January 2024

This study examines the distinct and complementary roles of the components of teachers’ sense of personal efficacy (SPE) (instructional strategies deployment, classroom management, student engagement) in relation to their organizational performance (subjective performance, organizational citizenship behaviours individuals [OCBI] and organizations [OCBO]). Data were collected from 250 college teachers in Quebec. The results of the analyses show that only the instructional strategies deployment component of the SPE predict a single component of performance, namely OCBI. The study’s findings support the separate study of SPE components in relation to teachers’ organizational performance, as they do have distinct and complementary roles on organizational performance.
La collaboration intersectorielle en soutien aux pratiques éducatives inclusives, qu’en pensent les milieux de garde ?
Authors: Paquet Annie , Dionne Carmen , Rousseau Michel , Lemire Colombe , Dubé Annie-Claude
Published: January 2024

Collaboration is considered to be a key element of inclusive early childhood practices. To ensure effective collaboration, it is important to provide facilitating conditions as teams often encounter many challenges. The purpose is to describe intersectoral collaborative experiences from the perspective of childcare centres. One hundred and fifty-four childcare educators and 94 supervisors responded to an online survey. The results show that collaboration with partners from institutions or organizations to support the inclusion of young children is perceived positively. Despite the challenges, it is seen as helpful, particularly in terms of joint intervention planning.
Revue systématique : stratégies d’intervention des enseignants auprès des élèves ayant des besoins particuliers en situation d’intimidation
Authors: Tremblay Kelly , Poulin Marie-Hélène , Guimond Fanny-Alexandra
Published: January 2024

Bullying in primary schools is a concern, especially for students with special needs. Despite the implementation of preventative programmes, teachers are lacking intervention strategies. This review focuses on teachers’ interventions in bullying situations experienced by students with special needs and their effects on bullying and victimization rates. Four databases were searched for a total of 417 articles. Ten of these articles (2008 to 2019) were selected and none report results specific to students with special needs. Teachers prioritize strategies that are not supported by research, such as punishment. The results are discussed in relation to research and real-live needs.
Le concept de représentations professionnelles : l’exemple des préceptrices sages-femmes
Authors: Lafrance Josée
Published: January 2024

University level midwifery education programs include theoretical contents and practical experiences. In Quebec (Canada), a practising midwife, called preceptor, is responsible for supervising students in the clinical setting. The aim of this paper is to present the concept of professional representations to all professionals who contribute to the practical education of students. In order to do so, numerous texts support the explanations on preceptorship and the concept of professional representations. This concept is presented in relation to midwifery, but more specifically using the example of preceptorship in midwifery training. The concept of professional representations is presented according to its functions, its content, and its levels of analysis.
El Índice de Desarrollo Socioeducativo (IDSEDU): un nuevo indicador para una educación ciudadana, integral y holística
Authors: Molina-Luque Fidel
Published: January 2024

El presente artículo es fruto de una investigación cualitativa, en el marco de un trabajo previo de Teoría Fundamentada (2011-2021), aprovechada para la elaboración de un Proyecto Educativo de Ciudad (PEC), en el que se ha incluido un innovador Índice de Desarrollo Socioeducativo (IDSEDU, 2021) que tiene por objetivo evaluar y validar las diferentes políticas educativas desde las diversas concejalías del ayuntamiento de una ciudad educadora. Se ha realizado un análisis bibliográfico y documental preliminar durante dos años (2022 y 2023) para consolidar el marco teórico y conceptual, y la comparación con otros ejemplos de ciudades educadoras. Se han organizado 4 equipos de trabajo para analizar la información y debatir alrededor de la pregunta inicial sobre lo que significa ser una ciudad educadora y la finalidad de un PEC, en el marco de un análisis DAFO, buscando las Debilidades, Amenazas, Fortalezas y Oportunidades, en un diagnóstico lo más completo posible. En este sentido, se han realizado un total de 45 entrevistas en profundidad y 2 Focus Group. El resultado es un índice que no es prescriptivo, sino orientativo, que ofrece un marco de comprensión de la realidad y, al mismo tiempo, un marco para la acción y para la transformación social. Es un índice que también es un decálogo de principios de acción, para procurar una ciudad Inclusiva, Intercultural e Intergeneracional, que supere las discriminaciones (los -ismos: racismo, clasismo, patriarcalismo/sexismo y edadismo), y que identifica los ejes de la Educación en la Solidaridad, la Sostenibilidad y la Socialización Profigurativa.
High-pressure synthesized perovskite-type CeTaN2O and its magnetic and electrical properties
Authors: Chen Zhao-Liang , Lu Da-Biao , Ye Xu-Bin , Zhao Hao-Ting , Zhang Jie , Pan Zhao , Chi Zhen-Hua , Cui Tian , Shen Yao , Long You-Wen ,   Institute of High Pressure Physics, School of Physical Science and Technology, Ningbo University, Ningbo 315211, China,   Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China,   School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China,   Institute of Plasma Physics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China,   Songshan Lake Materials Laboratory, Dongguan 523808, China
Published: January 2024

Recently, it has been discovered that the AB(N,O)3-type perovskite oxynitrides exhibit excellent dielectric, ferroelectric, and photocatalytic properties, promising for applications in the fields of optoelectronics, energy storage, and communication. Due to the differences in charge, ionic radius, and covalent bonding between N3– ion and O2– ion, the N substitution for O enhances the B(N,O)6 octahedron tilting, giving rise to exotic properties and functionalities. However, the current fabrication process for this type of material is rather time-consuming, leading to products with an appreciable quantity of impurities. In this study, using oxide precursors and sodium amide as the nitrogen source, high-purity perovskite-type oxynitride CeTaN2O bulk materials are successfully synthesized under high-temperature and high-pressure conditions provided by a cubic-anvil press. The synthesis time decreases to 1 h, achieving rapid production. The lattice structure and physical properties of the obtained samples are comprehensively investigated. X-ray powder diffraction experiments and subsequent Rietveld refinement indicate that the title material shows an orthorhombic crystal structure with the space group of Pnma. The X-ray absorption spectra confirm the charge configuration and the anion composition as Ce3+Ta5+N2O. Magnetization and specific heat measurements reveal that the exchange interactions are mainly antiferromagnetic, with a potential magnetic transition below 2 K. The electrical transport data demonstrate typical semiconductor behaviors, which can be further explained by a three-dimensional variable-range hopping model. Our study paves the way for putting this exotic perovskite oxynitride into practical applications.
Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet
Authors: de la Fuente Carla , Grondin Alexandre , Sine Bassirou , Debieu Marilyne , Belin Christophe , Hajjarpoor Amir , Atkinson Jonathan A , Passot Sixtine , Salson Marine , Orjuela Julie , Tranchant-Dubreuil Christine , Brossier Jean-Rémy , Steffen Maxime , Morgado Charlotte , Dinh Hang Ngan , Pandey Bipin K , Darmau Julie , Champion Antony , Petitot Anne-Sophie , Barrachina Celia , Pratlong Marine , Mounier Thibault , Nakombo-Gbassault Princia , Gantet Pascal , Gangashetty Prakash , Guedon Yann , Vadez Vincent , Reichheld Jean-Philippe , Bennett Malcolm J , Kane Ndjido Ardo , Guyomarc'h Soazig , Wells Darren M , Vigouroux Yves , Laplaze Laurent
Published: January 2024

Seedling root traits impact plant establishment under challenging environments. Pearl millet is one of the most heat and drought tolerant cereal crops that provides a vital food source across the sub-Saharan Sahel region. Pearl millet’s early root system features a single fast-growing primary root which we hypothesize is an adaptation to the Sahelian climate. Using crop modeling, we demonstrate that early drought stress is an important constraint in agrosystems in the Sahel where pearl millet was domesticated. Furthermore, we show that increased pearl millet primary root growth is correlated with increased early water stress tolerance in field conditions. Genetics including genome-wide association study and quantitative trait loci (QTL) approaches identify genomic regions controlling this key root trait. Combining gene expression data, re-sequencing and re-annotation of one of these genomic regions identified a glutaredoxin-encoding gene PgGRXC9 as the candidate stress resilience root growth regulator. Functional characterization of its closest Arabidopsis homolog AtROXY19 revealed a novel role for this glutaredoxin (GRX) gene clade in regulating cell elongation. In summary, our study suggests a conserved function for GRX genes in conferring root cell elongation and enhancing resilience of pearl millet to its Sahelian environment.
The ability to sense the environment is heterogeneously distributed in cell populations
Authors: Goetz Andrew , Akl Hoda , Dixit Purushottam
Published: January 2024

Channel capacity of signaling networks quantifies their fidelity in sensing extracellular inputs. Low estimates of channel capacities for several mammalian signaling networks suggest that cells can barely detect the presence/absence of environmental signals. However, given the extensive heterogeneity and temporal stability of cell state variables, we hypothesize that the sensing ability itself may depend on the state of the cells. In this work, we present an information-theoretic framework to quantify the distribution of sensing abilities from single-cell data. Using data on two mammalian pathways, we show that sensing abilities are widely distributed in the population and most cells achieve better resolution of inputs compared to an ‘average cell’. We verify these predictions using live-cell imaging data on the IGFR/FoxO pathway. Importantly, we identify cell state variables that correlate with cells’ sensing abilities. This information-theoretic framework will significantly improve our understanding of how cells sense in their environment.
Optogenetic stimulation of the locus coeruleus enhances appetitive extinction in rats
Authors: Lui Simon , Brink Ashleigh , Corbit Laura
Published: January 2024

Extinction is a specific example of learning where a previously reinforced stimulus or response is no longer reinforced, and the previously learned behaviour is no longer necessary and must be modified. Current theories suggest extinction is not the erasure of the original learning but involves new learning that acts to suppress the original behaviour. Evidence for this can be found when the original behaviour recovers following the passage of time (spontaneous recovery), or reintroduction of the reinforcement (i.e., reinstatement). Recent studies have shown that pharmacological manipulation of noradrenaline (NA) or its receptors can influence appetitive extinction, however, the role and source of endogenous NA in these effects is unknown. Here, we examined the role of the locus coeruleus (LC) in appetitive extinction. Specifically, we tested whether optogenetic stimulation of LC neurons during extinction of a food-seeking behaviour would enhance extinction evidenced by reduced spontaneous recovery in future tests. LC stimulation during extinction trials did not change the rate of extinction but did serve to reduce subsequent spontaneous recovery suggesting that stimulation of the LC can augment reward-related extinction. Optogenetic inhibition of the LC during extinction trials reduced responding during the trials where it was applied, but no long-lasting changes in the retention of extinction were observed. Since not all LC cells expressed halorhodopisn, is possible that more complete LC inhibition or pathway-specific targeting would be more effective at suppressing extinction learning. These results provide further insight into the neural basis of appetitive extinction, and in particular the role of the LC. A deeper understanding of the physiological bases of extinction can aid development of more effective extinction-based therapies.
Nifuroxazide Suppresses PD-L1 Expression and Enhances the Efficacy of Radiotherapy in Hepatocellular Carcinoma
Authors: Zhao Tiesuo , Wei Pengkun , Zhang Congli , Zhou Shijie , Liang Lirui , Guo Shuoshuo , Yin Zhinan , Cheng Sichang , Gan Zerui , Xia Yuanling , Zhang Yongxi , Guo Sheng , Zhong Jiateng , Yang Zishan , Tu Fei , Wang Qianqing , Bai Jin , Ren Feng , Feng Zhiwei , Jia Huijie
Published: January 2024

Radiation therapy is a primary treatment for hepatocellular carcinoma (HCC), but its effectiveness can be diminished by various factors. The over-expression of PD-L1 has been identified as a critical reason for radiotherapy resistance. Previous studies have demonstrated that nifuroxazide exerts antitumor activity by damaging the Stat3 pathway, but its efficacy against PD-L1 has remained unclear. In this study, we investigated whether nifuroxazide could enhance the efficacy of radiotherapy in HCC by reducing PD-L1 expression. Our results showed that nifuroxazide significantly increased the sensitivity of tumor cells to radiation therapy by inhibiting cell proliferation and migration while increasing apoptosis
in vitro
. Additionally, nifuroxazide attenuated the up-regulation of PD-L1 expression induced by irradiation, which may be associated with increased degradation of PD-L1 through the ubiquitination-proteasome pathway. Furthermore, nifuroxazide greatly enhanced the efficacy of radiation therapy in H22-bearing mice by inhibiting tumor growth, improving survival, boosting the activation of T lymphocytes, and decelerating the ratios of Treg cells in spleens. Importantly, nifuroxazide limited the increased expression of PD-L1 in tumor tissues induced by radiation therapy. This study confirms, for the first time, that nifuroxazide can augment PD-L1 degradation to improve the efficacy of radiation therapy in HCC-bearing mice.
Structural insights into the GTP-driven monomerization and activation of a bacterial LRRK2 homolog using allosteric nanobodies
Authors: Galicia Christian , Guaitoli Giambattista , Fislage Marcus , Gloeckner Christian Johannes , Versées Wim
Published: January 2024

Roco proteins entered the limelight after mutations in human LRRK2 were identified as a major cause of familial Parkinson’s disease. LRRK2 is a large and complex protein combining a GTPase and protein kinase activity, and disease mutations increase the kinase activity, while presumably decreasing the GTPase activity. Although a cross-communication between both catalytic activities has been suggested, the underlying mechanisms and the regulatory role of the GTPase domain remain unknown. Several structures of LRRK2 have been reported, but structures of Roco proteins in their activated GTP-bound state are lacking. Here, we use single-particle cryo-electron microscopy to solve the structure of a bacterial Roco protein (CtRoco) in its GTP-bound state, aided by two conformation-specific nanobodies: NbRoco1 and NbRoco2. This structure presents CtRoco in an active monomeric state, featuring a very large GTP-induced conformational change using the LRR-Roc linker as a hinge. Furthermore, this structure shows how NbRoco1 and NbRoco2 collaborate to activate CtRoco in an allosteric way. Altogether, our data provide important new insights into the activation mechanism of Roco proteins, with relevance to LRRK2 regulation, and suggest new routes for the allosteric modulation of their GTPase activity.
New genera of Afrotropical Chalcidoidea (Hymenoptera: Cerocephalidae, Epichrysomallidae, Pirenidae and Pteromalidae)
Authors: Mitroiu Mircea-Dan , Rasplus Jean-Yves , van Noort Simon
Published: January 2024

As a preliminary step towards the development of a key to genera of several families of Afrotropical Chalcidoidea, seven new genera in four families are described: Cerocephalidae–Milokoa Mitroiu, gen. nov. (type species: Milokoa villemantae Mitroiu, sp. nov.); Epichrysomallidae–Delvareus Rasplus, Mitroiu & van Noort, gen. nov. (type species: Delvareus dicranostylae Rasplus, Mitroiu & van Noort, sp. nov.); Pirenidae–Afrothopus Mitroiu, gen. nov. (type species: Afrothopus georgei Mitroiu, sp. nov.); Pteromalidae–Kerangania Mitroiu, gen. nov. (type species: Kerangania nuda Mitroiu, sp. nov.), Pilosalis Mitroiu, Rasplus & van Noort, gen. nov. (type species: Pilosalis barbatulus Mitroiu, sp. nov.), Scrobesia Mitroiu & Rasplus, gen. nov. (type species: Scrobesia acutigaster Mitroiu & Rasplus, sp. nov.), and Spiniclava Mitroiu & Rasplus, gen. nov. (type species: Spiniclava baaiensis Mitroiu & Rasplus, sp. nov.). Additionally, the following new species are described: Pilosalis bouceki Mitroiu & Rasplus, sp. nov., Pilosalis eurys Mitroiu & van Noort, sp. nov., Pilosalis minutus Mitroiu, sp. nov., Pilosalis platyscapus Mitroiu, Rasplus & van Noort, sp. nov., Scrobesia pondo Mitroiu, sp. nov., and Spiniclava setosa Mitroiu, sp. nov. All taxa are illustrated and the relationships with similar taxa are discussed. For each non-monotypic genus a key to species is provided.
The prognostic significance of lymph nodes in patients with pT1c33N0M0 non-small cell lung cancer: a retrospective study
Authors: Yang Wei , Wang Luyi
Published: January 2024

Objective

The objective of this study was to appraise the prognostic impact of lymph nodes in patients diagnosed with pT1c33N0M0 non-small cell lung cancer (NSCLC) and to delve into the prognostic significance of lymph nodes located at the N1 lymph node station in this patient cohort.

Methods

A retrospective analysis of clinical data was conducted for 255 patients diagnosed with pT1c33N0M0 NSCLC. Lymph nodes were tabulated and categorized into three groups (0–10 nodes, 11–16 nodes, >16 nodes). Clinical data among these three groups of pT1c33N0M0 NSCLC patients were compared. We conducted both univariate and multivariate analyses to pinpoint the factors that impact the prognosis of patients with pT1c33N0M0 non-small cell lung cancer (NSCLC). Additionally, we employed receiver operating characteristic (ROC) curve analysis to pinpoint the optimal lymph node criteria at the N1 station for prognostic prediction in pT1c33N0M0 NSCLC patients.

Results

Within the cohort of 255 individuals afflicted with pT1c33N0M0 non-small cell lung cancer (NSCLC), a comprehensive tally of 3,902 lymph nodes was diligently established, yielding an average of 15.3 nodes for each patient. Multivariate analysis demonstrated that tumor size, T stage, and lymph nodes were independent factors significantly impacting the prognosis of pT1c33N0M0 NSCLC patients (P < 0.05). ROC curve analysis revealed an area under the curve of 0.6982 for predicting prognosis using N1 station in pT1c33N0M0 NSCLC patients. The maximum Youden index was observed at an N1 station of 2.7 nodes. Patients with N1 station ≥ three nodes had significantly better prognoses compared to those with < 3 nodes (both P < 0.05).

Conclusion

Lymph nodes serve as an independent prognostic factor for pT1c33N0M0 NSCLC patients. Detecting at least three or more lymph nodes at the N1 station is associated with a more favourable prognosis in pT1c33N0M0 NSCLC patients.
Tackling Infectious Diseases with Special Reference to India: Need for Multidimensional Approach
Authors: Hassan Yasmeena , Dar Ishfaq Majeed , Uddin Jahangir Mohi , Saleem Sadaf , Rather Mohd Younis , Waza Ajaz Ahmad
Published: January 2024

Infectious diseases have long been a major cause for concern since they frequently result in pandemics. Undoubtedly, we have some degree of infection control, but the recent COVID-19 outbreak has reduced us to powerless bystanders watching people perish. The majority of infection-related deaths are caused by respiratory viral diseases, including tuberculosis. The oncovirus as a cause of cancer is a severe health issue that demands attention. The emergence of new harmful forms worsens the problem of infectious diseases. The antigenic profile of pathogens is constantly shifting, which reduces the effectiveness of vaccines or encourages the emergence of medication resistance. The necessity for an all-inclusive strategy is apparent after undertaking a thorough analysis of the scientific knowledge now in existence regarding genesis, transmission, pathophysiology, and availability, as well as the efficacy of medications against infections. There are many grey regions that require attention. For instance, we need to comprehend the biology of the diseases that new infections cause as well as the origin of those infections, the processes and factors that make some hosts vulnerable while others are resistant, the comorbid factors in a population that favours certain infections, and the potential oncogenic viruses of common cancers. We only have a few antimicrobial medicines or vaccines, and many of them are losing their efficacy daily due to bacteria' development of clever neutralizing defences. To find novel therapeutic targets, we must launch a comprehensive research effort. As an alternative, we must go the other way by utilizing passive immunity strategies or researching antiviral medicinal plant products, created chemical analogues, probiotics, and their derived bacteriocins that will demonstrate effective effects against pathogenic bacteria. The action's mechanism can then be understood. As a result, it is imperative that everyone work together to complement one another's skills in order to launch a multifaceted strategy to fill in all the knowledge gaps related to infectious diseases.
SILENT REVOLUTION IN NORTHERN SONG: THE POWER LOGIC BEHIND ZUNWANG RANGYI
Authors: Huo Xiaobin
Published: January 2024

This article examines the formation logic behind the principle of Zunwang Rangyi in early Northern Song dynasty (960－1127) of China. A common interpreting mode for the formation of the theory of Zunwang Rangyi is the externality approach that it’s the threat of military lords and “barbarian” invasion that promoted the formation of the institutional devices based on the principles of Zunwang Rangyi in the Song dynasty. I propose another internality approach by studying how Zunwang Rangyi theory has been transformed in early Northern Song by internally driven factors caused by the Shidafu crisis and how its core principles were mirrored in early Northern Song’s institutional design and state building. With a historical and documentation methodology with a focus on the work of several thinkers of early Northern Song, this research would enrich the current scholarship on the formation and evolution of institutional and state building of early Northern Song and its intellectual background.
Adolescent induced abortion in Benin City, Nigeria
Authors: Omu A.E. , Oronsaye A.U. , Faal M.K.B. , Asuquo E.E.J.
Published: April 2004

Induced adolescent abortion is a major cause of maternal and gynecologic death in the University of Benin Teaching Hospital, where 244 out of 349 such cases seen from January 1, 1974 to December 31, 1979 were reviewed. Ignorance and lack of contraceptive facilities were contributory factors. To deal with this problem that has been pervasive throughout Nigeria for the past decade, the authors advocate sex education, systematic dissemination of information for planned and conscientious parenthood as well as free availability of alternative methods of contraception. Interruption of early pregnancy should be an essential component of a national family planning program.
Obstetric performance of patients with my asthenia gravis
Authors: Giwa‐Osagie O.F. , Newton J.R. , Larcher V.
Published: April 2004

Over a 10‐year period, there were nine pregnancies in six myasthenic patients. In six of the nine pregnancies, there was an exacerbation of the disease, usually during the second trimester; in two pregnancies, drug requirements did not alter. One patient improved during pregnancy. Labor was efficient and uneventful, resulting in nine live babies, including one set of twins. Breastfeeding is not contra‐indicated. The previously reported puerperal deterioration of myasthenia gravis is not a feature of this series.
Pregnancy and delivery at the age of forty and over
Authors: Kujansuu Erkki , Kivinen Seppo , Tuimala Risto
Published: April 2004

One hundred and eighty‐six deliveries from mothers of age 40 and over at Oulu University Central Hospital during 1975–1977 are summarized. The commonest maternal complications were pre‐eclampsia (25.8%) and pathological glucose tolerance (7.0%). The cesarean section rate of the whole group was 16.7%, and for the primiparas, 47%. Placental complications were slightly but not significantly more common among parturients over 40 compared with our general obstetric population. The pregnancies did not adversely affect the mothers' health despite commonly occurring maternal diseases.

The commonest pathological findings among the newborns were hyperbilirubinemia (7.9%), neonatal infections (4.2%), clavicular fractures (3.2%) and postpartum asphyxia (2.6%). Congenital anomalies occurred in 2.6% of the children and were the main cause of the perinatal mortality, which was 5/189 (2.6%). Prematurity and low birth weight were not increased.
Multiple primary neoplasms of the ovary and uterus
Authors: Choo Yew Cheong , Naylor Bernard
Published: April 2004

Multiple primary neoplasms arising in the ovary and uterus were analyzed in 55 patients: 49 synchronous and 6, metachronous. When they occurred synchronously, 74.5% of the ovarian carcinomas and 93.6% of the uterine carcinomas were stage I lesions. The endometrial carcinomas were invariably well differentiated and superficial. It was the stage of the ovarian carcinomas that determined the prognosis of these patients. Ways of their identification as separate neoplasms are discussed. The potential to develop further neoplasms in the gastrointestinal tract and breasts should be borne in mind.
Morphological and immunohistochemical evidence of human papilloma virus (HPV) involvement in the dysplastic lesions of the uterine cervix
Authors: Syrjänen K. , Väyrynen M. , Castrén O. , Mäntyjärvi R. , Pyrhönen S. , Yliskoski M.
Published: April 2004

A series of 110 biopsies of the uterine cervix containing dysplastic and/or in situ changes were assessed morphologiccally with reference to presence or absence of the coexistent condylomatous lesions, and using the immunoperoxidase‐PAP technique to disclose the HPV (human papilloma virus) antigens in the cells.

Morphologically, 79 biopsies contained condylomatous (CO) lesions (63 flat, 12 inverted and 4 papillomatous ones), and 31 were non‐condylomatous (NCO) dysplasias/ in situ carcinomas. The mean age of the CO group was more than 10 years less than that of NCO women (P < 0.0001). Of the papillomatous COs, 75% were associated with mild or moderate dysplasia only, whereas 42% of the inverted ones contained an associated in situ carcinoma. Most of the flat lesions were found in very young women (10–39 years of age).

HPV antigens were demonstrated in all papillomatous lesions (100%), in 83% of the inverted ones, and in 67% of the flat COs. In generally, the frequency of the HPV‐positive cases decreased when epithelial atypia increased. None of the NCO lesions showed HPV positive cells.

The results support earlier morphological findings on the frequent association of cervical condylomas and epithelial dysplasias, as well as those on the HPV as the etiologic agent of the former. The role of HPV as a possible etiologic agent of the cervical squamous cell neoplasia deserves further attention.
Frozen section biopsy of ovarian neoplasms
Authors: Da Cunha Bastos Alvaro , Salvatore Carlos Alberto , Faria Roberto Mazza
Published: April 2004

In a study of the frozen section biopsy of 120 ovarian neoplasms, correct results were obtained in 94.16%, incorrect in 4.16%, and inconclusive in 1.66% of the 120 cases. The “incorrect” results were all “false‐negative.” No inverse “false‐positive” results were recorded, and the “incorrect” results occurred in cases of encapsulated neoplasms of a macroscopically benign appearance with small areas of malignant changes detected only by paraffin block technique. The authors conclude that frozen section biopsy of ovarian neoplasm is plausible so long as a pathologist is available who can be provided with the proper equipment during the surgery and that the technique is more indicated in patients up to the age of 40 because of the necessity of conservative management in this age group.
Human placental lactogen, pregnancy‐specific beta‐1‐glycoprotein and alpha‐fetoprotein in serum in threatened abortion
Authors: Hertz Jens B. , Schultz‐Larsen Peter
Published: April 2004

The predictive value of HPL, SP1 and AFP in serum were determined in 109 women admitted to hospital because of vaginal bleeding in the 6th to 19th gestational week. The prediction of abortion based on the initial analysis from the day of admission was found to be 91.7%, 75.9% and 81.8% for HPL, SP1 and AFP, respectively. The corresponding values for prediction of successful outcome were 68.7%, 73.6% and 65.4%. The HPL and AFP determinations were, however, found to be valid only after the 9th and 12th gestational week, respectively. A highly significant positive correlation (r = 0.84, P < 0.001) was demonstrated between HPL and SP1 suggesting that SP1 measurements might replace HPL in the evaluation of the prognosis in threatened abortion.
Carbon dioxide hysteroscopy immediately after second trimester abortion
Authors: Van Lith D.A.F. , Beekhuizen W. , Van Schie K.J. , Van Der Pas H. , Lindemann H.J.
Published: April 2004

The use of hysteroscopy has been restricted a.o. by the need for general anesthesia. This applies in particular to the pre‐ or postpartum period, because the hyperemic atonic uterus is easily over‐inflated to a dangerous level. Over‐inflation did not occur following 50 aspirotomy D & E procedures in the second trimester, using a para‐ and intracervical block with lidocaine 1% with adrenaline 1:200,000 only. The uterine cavity was always thoroughly evacuated in these cases in which final check suction had been performed. We recommend that postabortum hysteroscopy should be performed preferably under local anesthesia.
Cephalopelvic disproportion at term involving a lithopedion: A case report
Authors: Leke R.J.I. , Nasah B.T. , Shasha W. , Monkam G.
Published: April 2004

A case of obstructed labor in a term pregnancy caused by cephalopelvic disproportion as a result of a lithopedion retained in a sacculus of the lower uterine segment is reported. Detection and management of this condition are discussed, and a review of relevant literature is also presented.
A rare cause of cholecystitis in pregnancy
Authors: Lewis Graham John
Published: April 2004

A case of typhoid cholecystitis presenting in pregnancy with acute symptoms and signs is reported. The patient failed to respond adequately to conservative treatment, and surgical intervention was required. The outcome of the pregnancy was satisfactory. The management of such a case is discussed.
Dysmenorrhea in women with intrauterine contraceptive device. Treatment with a prostaglandin synthetase inhibitor, naproxen
Authors: Lalos Othon , Nilsson Berit
Published: April 2004

Twenty‐one women with intrauterine contraceptive devices (IUCD) and severe dysmenorrhea were studied. All the women who participated in the study had primary dysmenorrhea of varying intensities. The insertion of IUCD increased the intensity of dysmenorrheic pain. The effect of naproxen (Naprosyn®) on pain alleviation was studied in a double‐blind cross‐over trial using naproxen and placebo. The effect of naproxen was significantly better than that of placebo (P < 0.01). No severe side effects occurred during the treatment. There was no difference in the duration and amount of the menstrual blood flow during naproxen treatment compared to placebo according to the women's own judgement.
Intrapartum rupture of uterus diagnosed by ultrasound: A case report
Authors: Suonio S. , Saarikoski S. , Kääriäinen J. , Virtanen R.
Published: April 2004

A case of ruptured uterine scar of a previous cesarean section diagnosed by ultrasound is presented. Because of the severity of the complication and the great variation of symptoms in connection with it, the authors encourage the use of ultrasound screening in the detection of this rare, but often catastrophic complication.
The treatment of rupture of the pregnant uterus. Analysis of 93 cases treated in a rural hospital in Zambia
Authors: Heij H.A. , Te Velde E.R. , Cairns J.M.
Published: April 2004

In this study 93 cases of uterine rupture, treated in a rural hospital in Zambia have been analyzed. Clinical characteristics and mortality rate were found to be comparable to those reported in other series from developing countries. An attempt was made to compare the outcome of various surgical procedures. No statistically significant differences were found between the mortality rates after repair, subtotal and total hysterectomy (12%, 13% and 28%, respectively). A survey of recent literature on the treatment of uterine rupture in developing countries revealed a wide divergence of opinions and criteria of selection, precluding reliable comparisons. A proposition for individualized treatment is outlined, concluding that repair should be performed when suitable but that hysterectomy is preferable when the tear is extensive, bruised and contaminated.
Low serum selenium concentration in patients with cervical or endometrial cancer
Authors: Sundström Helena , Yrjänheikki Erkki , Kauppila Antti
Published: April 2004

Serum concentrations of selenium were determined in 37 patients with cervical and 64 patients with endometrial cancer. The patients had lower (P < 0.001) serum concentrations of selenium than the age‐, weight‐ and place of residence‐matched paired control women. There was no difference in the selenium concentration between various age groups or different clinical stages of cervical or endometrial cancer. A low serum concentration of selenium might be a contributing factor in uterine carcinogenesis.
Quantitation of immunoglobulin A in the human chorioamniotic membrane
Authors: Berezowski A.T. , Cunha S.P. , Costa J.C. , Santos R.R. , Duarte G.
Published: April 2004

Thirty‐eight chorioamniotic membranes were obtained from normal patients divided into three groups according to time of rupture. A protein extract was obtained by destruction and differential centrifugation and immunoglobulin A was measured by the method of Mancini. The authors demonstrated that it is possible to quantitate immunoglobulin A. No statistically significant differences were observed between groups.
The value of laparoscopy in women with chronic pelvic pain and a “normal pelvis”
Authors: Levitan Zohar , Eibschitz Izu , de Vries Karl , Hakim Marwan , Sharf Mordechai
Published: April 2004

During the period January 1976–December 1982 laparoscopy was performed on 186 women complaining of pelvic pain of at least 6 months' duration. In all these cases, the routine pelvic examination and other medical and laboratory tests were negative. Laparoscopy revealed pelvic pathology in only 8.2%: in the vast majority (91.8%) entirely normal pelvic organs were seen. Evidence from the literature is compiling as to the psychogenic origin of most cases of chronic pelvic pain. Recently, it has been shown that laparoscopically negative pelvic pain can be relieved or abolished by psychological intervention. Since pathological findings on laparoscopy are of very low percentage and since the pain is psychogenic in most cases, the value of routine laparoscopy in chronic pelvic pain is very low. We propose that all women with chronic pelvic pain and normal pelvic examination should undergo psychological assessment and treatment if necessary. Laparoscopy should then be reserved for only those cases who show no amelioration on psychological intervention. Our estimation is that this approach would reduce the rate of laparoscopies performed for chronic pelvic pain by about 90%.
The use of bromocriptine in hyperprolactinemia and galactorrhea in Singapore
Authors: Tsakok F.H.M. , Yong Y.M. , Ng C.S.A.
Published: April 2004

Ninety‐four women and seven men were treated with low dose bromocriptine for (a) hyperprolactinemia or (b) normoprolactinemia but with galactorrhea and a pituitary adenoma. All the pituitary adenomas became smaller or remained the same. Prolactin levels decreased with treatment and inappropriate galactorrhea improved in the 53 patients except for 7 where there was no change. Of the 41 women with premenstrual mastalgia 78% improved with treatment. Of the 74 women with ovulatory problems, a biphasic pattern was restored in 65 patients. Thirty‐two patients out of the 92 trying to conceive achieved a pregnancy with an abortion rate of 12.5% and non‐lethal congenital abnormality of 9.8% (2.1% in Singapore population). Fertility was restored in 3 hyperprolactinemic oligospermic males and improved libido was professed by most of the treated men. Side effects were present but were on the whole tolerable.

Pregnancy rate was better in those with high levels of prolactin (>1000 miU/l) than in those with hyperprolactinemia of between 500 and 1000 miU/l although this was not statistically significant χ2 = 0.69. In the lower hyperprolactinemic range there was noticeable number of patients with endometriosis and increased luteinizing hormone (LH) levels.