bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Pharmacist’s Role in Optimizing Therapy through Drug-Related Problems Identification
Authors: Debora Liana , Susanti Eni , Suharjono Suharjono
Published: February 2022

Clinical pharmacists play an important role in a clinical setting as part of a team. Drug-related problem (DRP) is the main part pharmacist should focus on to achieve the optimal therapy for patients. Therefore, this study aimed to investigate the role of clinical pharmacy in a private hospital of West Java, Indonesia, and describe the prevalence of DRPs and several factors associated with the risk of DRPs. The clinical pharmacist's monthly report was obtained from June to August 2020. Furthermore, problems, causes, and types of DRP were identified using PCNE Classification V9.1. Drug classes and other factors related to DRP were also investigated. This was a descriptive study with a retrospective approach to medical records, where 240 DRPs were identified in 157 patients. Approximately 4.45% experienced DRP, especially in ICU at 45.83% and Stroke Unit or SU-IC at 25.42%. The most common DRPs were incomplete drug treatment, drug interaction, and dose adjustment. Antimicrobial, cardiovascular agents, and PPI were the most commonly involved. In the linear regression analysis, length of stay and number of therapy significantly affect DRP. In this study, pharmacists intervented each DRP, with 57% accepted as fully and partially implemented by the physicians. A total of 22% of interventions ended with unknown status due to limited follow-up time. Meanwhile, reviews on medication by clinical pharmacists lead to improvement in drug treatment. The implementation of clinical pharmacy services shows many DRPs to be prevented and increases therapy optimization.
The Effect of Writing Gratitude in Buku Syukur Beta on Depression Severity in Type-2 Diabetes Mellitus Patients
Authors: Rengga Maria P. E. , Stephani Maria
Published: February 2022

According to the World Health Organization (WHO), diabetes mellitus (DM) is the 6th and 5th cause of death worldwide (2015) and in Indonesia, respectively. Compared to non-diabetic, patients with DM are reported to be about 1.4–3 times to suffer from comorbid depression. Previous research has shown that writing a gratitude journal every day for three weeks affected pure neural altruism. Therefore, this study aimed to provide the effect of writing the expressions of gratitude in Buku Syukur Beta (BSB) on depression severity in type-2 DM patients. This is a single-blind randomized control trial (RCT) study in twelve (12) type-2 DM patients. The research subjects were the members of Program Pengelolaan Penyakit Kronis (Prolanis) at Oepoi Public Health Center, Kupang, Indonesia; mostly classified as elders. The study has the test and control group, consisting of six patients. For 60 days, the test group appreciated the BSB daily for 10 minutes or 2–5 sentences, while the control group wrote their daily activities in a diary (Buku Harian Beta). The depression severity was measured before and after treatment with the Patient Health Questionnaire-9 (PHQ-9). The independent samples t-test showed a significant reduction in depression severity with a p-value of 0.011 (p<0.05). This study concluded that writing the expressions of gratitude for 60 days in BSB reduced depression severity in type-2 DM patients.
Presentación del caso
Authors: Re Rodrigo , Negri Maximiliano
Published: February 2022

Se presenta un paciente de sexo femenino de 8 años que consulta por tumoración en el antebrazo, de 1 año de evolución, ligeramente dolorosa. En el examen físico, se palpa una lesión pétrea, poco móvil, sin dolor a la movilización. Se solicitan radiografías de codo de frente y de perfil, y se completa con una ecografía.
Coding for Pediatrics 2022
Authors:   Committee on Coding and Nomenclature (COCN),   American Academy of Pediatrics
Published: February 2022

The 27th edition of the AAP cornerstone coding publication has been completely updated to include all changes in pediatric-specific Current Procedural Terminology (CPT) and ICD-10-CM codes for 2022—complete with expert guidance for their application. The book's many clinical vignettes and examples, as well as the many coding pearls throughout, provide the added guidance needed to ensure accuracy and payment. (NOTE: This book features a full text reading experience. Click a chapter title to access content.)
Child Adversity and Trauma-Informed Care Teaching Interventions: A Systematic Review
Authors: Steen Mackenzie , Raynor Jennifer , Baldwin Constance D. , Jee Sandra H.
Published: February 2022

OBJECTIVES

Health professionals need training to provide trauma-informed care (TIC) for children with adverse childhood experiences (ACEs), which can affect short- and long-term health. We summarize and evaluate published curricula for health professionals on ACEs and TIC.

METHODS

We searched PubMed, Embase, Web of Science, CINAHL, Cochrane Central Register of Controlled Trials, PsychInfo, and MedEdPORTAL through January 2021. Studies meeting the following criteria were included: Described teaching interventions on ACEs, TIC, and child abuse and maltreatment; included health care providers or trainees as learners; were written in English; included an abstract; and described a curriculum and evaluation. We reviewed 2264 abstracts, abstracted data from 79 studies, and selected 51 studies for qualitative synthesis.

RESULTS

Studies focused on ACEs/TIC (27), child abuse (14), domestic/intimate partner violence (6), and child maltreatment/parental physical punishment (4). Among these 51 studies, 43 were published since 2010. Learners included a mix of health professionals (34) and students (17). Duration, content, and quality of the 51 curricula were highly variable. An analysis of 10 exemplar curricula on ACEs and/or TIC revealed high and very high quality for methods and moderate to very high quality for curriculum evaluation, suggesting that they may be good models for other educational programs. Four of the 10 exemplars used randomized controlled trials to evaluate efficacy. Studies were limited to English language and subject to publication bias.

CONCLUSIONS

ACEs and TIC are increasingly relevant to teaching health professionals, especially pediatricians, and related teaching curricula offer good examples for other programs.
ProtoThinking®: El diseño como conector entre una idea y su prototipo
Authors: Martínez Nel
Published: February 2022

Toda intención de innovación se gesta en el pensamiento y se consolida en la versión de una experiencia, una estrategia, un servicio, un producto, un modelo de negocio, una marca, etc. No hay versión final, todo resulta estar en un ciclo constante de validación, una suerte de estado beta permanente. ProtoThinking® es concepto y método. En cuanto concepto es una construcción mental o intención de aterrizar una idea al mundo real; en cuanto método, es consolidación y propone que esa idea sea estructurada y evaluada, para luego ser validada por los usuarios. El diseño como articulador entre una idea y su prototipo es la base de esta metodología derivada del concepto de pensamiento de diseño o design thinking (Brown, 2008), cuyo valor agregado es una combinación entre la sensibilidad del diseñador y la agudeza del gestor de negocios para ofrecer estrategias de innovación. Este artículo se centra en la descripción de la metodología ProtoThinking® y procura ofrecer aprendizajes y reflexiones derivados de su aplicación en las diferentes sesiones de workshop que, según sus objetivos y alcances, han sido validadas en empresas y organizaciones de diferentes sectores económicos.
Compression and Encryption of Vital Signals Using an SoC-FPGA
Authors: Gómez García Carlos Andres , Velasco Medina Jaime
Published: February 2022

This article presents the implementation of a remote monitoring system of biomedical signals with cybersecurity support and compression of vital sign signals and data of the patient. This system uses a low-cost microsystem for encrypting and compressing the information using the Lempel–Ziv–Welch (LZW) lossless compression algorithm and the Advanced Encryption Standard (AES). In this case, WolfSSL library is used for the implementation of the Transport Layer Security (TLS) protocol, whose encryption function is accelerated by the AES processor designed on a System on Chip - Field Programmable Gate Array (SoC-FPGA) device. A multiparameter board and an SoC-FPGA development board make up the vital signs measurement system, which was calibrated and verified by a commercial patient simulator. Data transmission tests were carried out from the measurement system to the monitoring application developed in LabVIEW and implemented on a personal computer (PC), where vital signs and data of the patient are decrypted and decompressed. Also, it was possible to verify a significant improvement in the performance of the TLS connection. From the results obtained, it can be concluded that the designed microsystem allows to compress, encrypt, and transmit biomedical data in real-time and without loss of information. The microsystem is very suitable for e-health platforms and/or e-health devices that use unsecured communication networks with limited bandwidth.
Application of biodegradable coatings on ‘Tommy Atkins’ mango for export
Authors: Bispo Coelho Paloma , Figueiredo Neto Acácio , Sousa Costa Marylia , Pereira Filho Antonio , Damasceno da Silva Tamires , Sánchez-Sáenz Carolina Maria
Published: February 2022

This study evaluates the effect of a low-cost biodegradable coating formulated with potato starch, rice starch, cassava starch, and gelatin on the postharvest quality of ‘Tommy Atkins’ mango. The experimental design was completely randomized, arranged in a 7x6 factorial scheme with four replications per treatment. The data were subjected to analysis of variance using the Tukey test at 5% probability. After coating, the fruits were stored under ambient conditions (25 ± 3 ºC and 65 ± 5% RH) for 10 days, with analysis every two days. The variables analyzed were: fruit firmness, weight loss, total soluble solids, total titratable acidity, total soluble solids/titratable acidity ratio, delta absorbance (DA) index, colorimetric analysis of the peel and pulp, and ascorbic acid content. The application of biodegradable coatings did not extend the shelf life of ‘Tommy Atkins’ mango during storage.
Permeability measurement in porous media under unsaturated paths
Authors: Galvis Luis Carlos , Ruge Cárdenas Juan Carlos , Galvis-Salamanca Luis Carlos , Pulgarín Morales Laura , Bastidas Juan Gabriel , Olarte Garzón María Camila
Published: February 2022

Understanding the flow through porous media when it is part of geotechnical-hydraulic structures has been a scenario calculated from the most unfavorable situation. The passage of water through the porous skeleton of the soil is considered in a saturated condition. Few studies to date consider partially saturated trajectories regarding the influence on the stability of a dam, reservoir, embankment, among others. Estimating the speed with which the fluid under analysis flows through a partially saturated media is challenging to perform by conventional methods. By contrast, nowadays, it is easy to obtain for saturated soil. This study aimed to measure hydraulic conductivity (coefficient of permeability) in granular soils using easily accessible laboratory techniques. The permeability in unsaturated conditions will be measured, varying the suction in the sample, which is an essential requirement when there is a situation of partial saturation. The results provided data on the permeability values that allow to obtain a very evident difference between both proposed conditions.
Survey and calculation of the energy potential and solar, wind and biomass EROI: application to a case study in Argentina
Authors: Camargo Federico Gabriel
Published: February 2022

The practical application of renewable energies to solve current environmental problems is still under discussion today. In this article, he surveyed the biomass and biogas potential available in Entre Ríos and usable in Concepción del Uruguay. In the first, the forestry, agro-industry and in the second the organic residues of the chickens are studied. A novel contribution is presented in relation to the Energy Return On Investment for renewable generation sources in Argentina, which measures its energy profitability, through the life cycle analysis for its calculation, by measuring energy expenses in different stages. This article seeks to reveal the main data that will be used in subsequent optimization work, especially in determining the energy profitability of generators and the optimization of distributed generation in medium voltage.
Poder soberano y control social: disciplinamiento y dominación durante la génesis del Estado colombiano, 1821-1850
Authors: Chaparro-Rodríguez Juan-Carlos
Published: February 2022

este artículo describe la situación social que se generó en Colombia durante las tres décadas siguientes a la consumación de la Independencia y analiza el propósito y alcance de los mecanismos de control que los legisladores y gobernantes crearon con el fin de mantener bajo dominio a la población y, especialmente, a los individuos y grupos que consideraron peligrosos para el orden social e institucional. A tal efecto, buscamos identificar el vínculo que se tejió entre esa empresa y la pretensión de constituir e imponer la soberanía del naciente Estado colombiano. Para realizar esta tarea, y apoyándonos en la documentación bibliográfica que se ha producido sobre la situación social de la época, lo mismo que en la legislación que las autoridades colombianas expidieron con el fin de llevar a cabo esa mentada obra, hemos examinado tanto el contenido de esas leyes como el sentido y propósito de los discursos e imaginarios que los autores y promotores de esa empresa construyeron con el fin de legitimar los dictámenes que emitieron sobre la materia en cuestión. Al proceder en estos términos hemos podido colegir que, aunque sus decisiones estuvieron legalmente amparadas en la autoridad del Estado, a efecto de esta misma esos hombres también pretendieron establecer un régimen de disciplinamiento, control y dominación social, funcional a los particulares intereses de algunos sectores dominantes.
La dictadura como concepto utilitario (Antioquia, 1813-1814)
Authors: Peña-Aristizábal Cindy
Published: February 2022

a inicios del siglo XIX se dieron en los territorios americanos una serie de revoluciones que conllevaron a la independencia de las antiguas colonias y a la creación de nuevas naciones, por lo que surgieron diversas ideas de gobierno y proyectos políticos basados en los ideales conocidos provenientes, en gran medida, del mundo europeo. Es por eso que en el presente artículo se establecen los motivos y posibles influencias —tanto sociales como culturales— que llevaron a la élite política del Nuevo Reino de Granada a recurrir a la implementación del concepto de dictadura en el año de 1813, aunque se hará especial énfasis en el discurso político surgido en torno a la figura de Juan del Corral, quien fue nombrado como dictador durante este período convulso en la provincia de Antioquia. En este sentido, se ha recurrido al análisis de archivos, gacetas, periódicos y textos constitucionales para estudiar la historicidad del concepto e identificar los motivos y fines políticos por los cuales este fue implementado, así como los debates que generó en la opinión pública sobre las posibles consecuencias que podrían derivarse de esta práctica.
Amigos en las alturas: José Figueres, Estados Unidos y la construcción de la Costa Rica de la posguerra
Authors: Fink Leon
Published: February 2022

El ascenso a la presidencia de Costa Rica de José Figueres en 1953, las actividades de sus enemigos en Nicaragua para darle un golpe de Estado y sus enfrentamientos con Somoza son hechos bien conocidos. En cambio, se conoce menos el papel de ciertos políticos en los Estados Unidos -especialmente “demócratas liberales”- en el sostenimiento y ayuda al gobierno de Figueres en contra de posibles actores hostiles en los Estados Unidos y en la región latinoamericana, así como dentro de Costa Rica. Este artículo se concentra en el papel de amigo de Figueres que tuvo el influyente economista del New Deal y Secretario de Estado para los asuntos latinoamericanos: Adolf Berle.
Molina Jiménez, I. y Díaz Arias, D., eds. (2021). El héroe de la discordia. Juan Rafael Mora Porras y la cultura costarricense. San José: Editorial de la Universidad de Costa Rica/CIHAC.
Authors: Gobat Michel
Published: February 2022

El héroe de la discordia: Juan Rafael Mora Porras y la cultura costarricense, editado por Iván Molina y David Díaz, es un libro muy rico, así que hay muchas maneras de analizarlo. Es cierto que el libro se centra en la figura de Juan Rafael Mora Porras. Pero al situar Mora en su contexto histórico y explorar las políticas de memoria que rodean su figura desde el siglo XIX hasta el presente, el libro ofrece una visión fascinante de la historia moderna de Costa Rica. Y el libro destaca no sólo por su amplio recorte temporal, sino también por sus diversos enfoques metodológicos, ya que tiene cosas importantes que decir sobre la historia política, la historia social, la historia literaria, y los estudios de la memoria.
Mega-Niño de 1925-1926 y sus repercusiones en la sociedad costarricense durante la segunda administración de Ricardo Jiménez Oreamuno (1924-1928)
Authors: Alfaro-Martínez Eric J. , Madriz-Sojo Gabriel , Díaz Bolaños Ronald E.
Published: February 2022

El objetivo del presente artículo consiste en caracterizar el evento extremo del Mega-Niño costero de 1925-1926 en el sur de América Central a partir de una serie de anomalías geofísicas calculadas mediante los registros meteorológicos de estaciones ubicadas en Costa Rica y Panamá. También, estudiar sus repercusiones en la sociedad costarricense durante la segunda administración de Ricardo Jiménez Oreamuno (1924-1928) a través del análisis documental de fuentes primarias oficiales y hemerográficas. Los hallazgos de este artículo permiten afirmar que este Mega-Niño se manifestó en Costa Rica a través de un incremento en la magnitud del viento alisio, temperaturas superficiales del aire y del océano más cálidas de lo usual y una disminución de las precipitaciones respecto a su valor promedio. Asimismo, que el fenómeno tuvo un impacto social ligado a condiciones de sequía; expresado en plagas de langostas, carestías de agua potable, descensos en los rendimientos de las cosechas y prolongaciones en las actividades de veraneo. También, se dio una afección de vientos fuertes y oleaje alto al comercio de cabotaje en el litoral pacífico, así como daños a infraestructuras costeras y urbanas. Se concluye que estas repercusiones sociales se concentraron a una escala local del país, y fueron moderadas en los distintos sitios de afección.
Análisis de la obra: ¿La rebeldía se volvió de derecha? Cómo el antiprogresismo y la anticorrección política están construyendo un nuevo sentido común (y por qué la izquierda debería tomarlos en serio), de Pablo Stefanoni
Authors: Sequeira Sofía Cortés
Published: February 2022

El avance electoral y la conquista de escaños en los parlamentos europeos es la expresión más visible del reciente auge de las extremas derechas en el mundo occidental, luego de la derrota del fascismo y la caída de las dictaduras militares de la segunda mitad del siglo XX. La fuerte crisis económica del 2008 fue el combustible y, desde ese entonces, el foco de atención se ha dirigido hacia los principales partidos y figuras políticas, como las caras de un fenómeno que es mucho más profundo y que se ha enquistado en las entrañas mismas de estas sociedades. En el continente americano, las recientes administraciones de Donald Trump en Estados Unidos, y de Jair Bolsonaro en Brasil, son las expresiones electorales domésticas más importantes de este fenómeno (Cano, 2021).
COVID-19 and ophthalmic herpes zoster co-infection in immunocompetent patient
Authors: Sissy Sissy , Santoso Adeline , Gotama Dewi , Rusyati Luh Made Mas
Published: February 2022

Background: Varicella-zoster virus (VZV) is a virus of human neurotropic that remains within ganglionic neurons in a latent state after the primary infection throughout the entire neuroaxis.Case: A male patient, 32 years old Javanese, consulted from the pulmonary division with complaints of vesicular eruption in the facial area on September 27, 2020. The patient was diagnosed with ophthalmic herpes zoster and a mild COVID-19 infection since 2 days ago and was hospitalized. Management in patients was acyclovir, methylprednisolone, with analgesics and vitamins. COVID-19 as co-infection and other viruses has been known, but infrequently affect the respiratory tract.Conclusion: Herpes zoster patient should ruled out the COVID-19 and maximize the precaution for personal safety equipment until the SARS-CoV-2 is excluded.
Study of neutrophil-lymphocyte ratio (NLR) in recent onset type 2 diabetes mellitus
Authors: Dudani Sharmila , Poodury Sanjiti , Mangalesh Sridhar
Published: February 2022

Introduction:Â The prevalence of type 2 diabetes mellitus (T2DM) is increasing steadily, assuming an epidemic proportion throughout the world. Most of this increased burden will come from developing countries. Studies show an increasing role of inflammation in the pathophysiology of diabetes. Estimation of neutrophil-lymphocyte ratio (NLR) could be a simple, inexpensive marker to stratify at-risk diabetes patients. This study aimed to estimate the NLR and CRP levels as a measure of systemic inflammation in diabetics compared to healthy controls. We also investigated if NLR was lower in diabetics with good glycemic control.Â Methods:Â A cross-sectional comparative study, conducted in a tertiary hospital on 60 patients with T2DM and 69 healthy controls after voluntary informed consent. Anthropometric parameters, fasting plasma glucose, Lipid profile, CBC, CRP, and HbA1c were measured for all participants.Â Results:Â The diabetic group showed significantly higher waist circumference(p=0.007) mean TG (p=0.003), VLDL-c (p=0.001), LDL-c (p=0.010), TG/HDL-c (p=0.001), HbA1c (p=0.00001), MPV (p=0.002), NLR (p=0.006), and CRP (p=0.004) values and lower HDL-c values (p=0.039) as compared to the control group. No significant difference was seen in BMI, Waist -Hip ratio, total cholesterol, and total cholesterol/HDL-c values between the two groups. Among the diabetics, only HDL-c (p=0.018) and TG/HDL-c ratio (p=0.049) differed significantly with glycemic control.Conclusion:Â Diabetics had higher inflammatory markers (NLR, CRP) as compared to controls. Dyslipidemia (high TG, low HDL-c with high TG/HDL-c) and a higher waist circumference were seen in diabetics. Diabetics with fair control of glycemia (HbA1c < 7%) did not demonstrate lower NLR levels indicating that meticulous glycemic control may not ameliorate the chronic inflammation seen in diabetics until dyslipidemia is corrected.Â
Intracranial stenosis in patients with post-ischemic stroke: a case-control study Rizaldy Pinzon1, Andre Dharmawan Wijono1
Authors: Pinzon Rizaldy , Wijono Andre Dharmawan
Published: February 2022

Background: Despite its remained position as the main culprit of stroke worldwide, studies on intracranial stenosis in Indonesia are still very limited. It is necessary to research to measure the prevalence and risk factors of intracranial stenosis in post-ischemic stroke. Method: We conducted case-control research with participants of 234 ischemic stroke patients. Each patient was listed for their risk factors and analyzed for their association with intracranial stenosis. Intracranial circulation was determined by transcranial doppler (TCD) sonography TD-DOP 9000 with a 2-MHz probe. A peak systolic velocity (PSV) of >140cm/s or mean systolic velocity of (MSV) >80cm/s were used as criteria for middle cerebral artery (MCA) stenosis. In contrast, PSV>90 cm/s or MSV>60cm/s were used to determine the posterior circulation stenosis. Statistical analysis used SPSS 18.0 software which The Independent t-test and chi-square test were used to assess significant differences in correlation to intracranial stenosis. P-value <0.05 was statistically significant.Result: Intracranial stenosis cases were 38%, with the anterior circulation being the most common stenosis location. Hypertension, diabetes mellitus and dyslipidemia were the most often risk factors. Only hypertension with OR=2.97 (95%CI=1.76-4.98) and diabetes mellitus with OR=1.48 (95%CI=1.12-2.43) were positively correlated with increased risk intracranial stenosis.Conclusion: The occurrence of intracranial stenosis in ischemic stroke patients was high and increased with the presence of hypertension or diabetes mellitus.
The relationship between self-esteem and husband support with body image perception in post-vaginal delivery primiparous mother in independent Delima midwife practice in Denpasar
Authors: Bomba Ignasius Yulianus Jagkson , Lesmana Cok Bagus Jaya , Diniari Ni Ketut Sri , Aryani Luh Nyoman Alit , Wahyuni Anak Ayu Sri , Ariani Ni Ketut Putri , Wardani Ida Ayu Kusuma , Ardani I Gusti Ayu Indah
Published: February 2022

Background: Childbirth is a big, happy event for a mother. In post-partum mothers, physical changes and psychological changes can occur. It is reported that 50% to 70% of post-partum mothers experience psychological disorders, such as a mother can feel uncomfortable with body image perception changes, which result in feelings of lack of husband support. Body image perception itself can cause an effect on self-esteem. This study aimed to analyze the relationship between self-esteem and husband's support with body image perception among primiparous mothers after vaginal delivery.Methods: An observational analytic study was conducted among 30 post-vaginal delivery primiparous mothers in independent Delima midwife practice in Denpasar. Data regarding respondentsâ€™ characteristics, self-esteem, husbandâ€™s support and body image perception were obtained using the Rosenberg self-esteem questionnaire, the Revised Dyadic Adjustment Scale (R-DAS) questionnaire Multidimensional Body-Self Relations Questionnaire Appearance Scales (MBSRQ-AS). The relationship between self-esteem and husband's support with body image perception was analyzed using SPSS version 23 for Windows.Results: The average age of the respondents were 24.73 years old, and most of them were graduated from high school (50%), employed (53.3%) and have no conflict in their marriage (80%), have normal self-esteem (96.6%), didnâ€™t get enough husbandâ€™s support (56.7%) and have positive perception regarding the evaluation of physical appearance (96.6%). We found a significant relationship between self-esteem and body image perception (p = 0.001), husband's support and body image perception (p = 0.001) and husband's support and self-esteem (p = 0.010) in post-vaginal delivery primiparous mother in independent Delima midwife practice in Denpasar.Conclusion: Self-esteem, husband's support and body image perception were essentials factors that contributed to post-partum woman mental health stability that should be understood by family and health workers to avoid psychological disorder in post-partum woman.
Simultaneous resection on the patient with synchronous colorectal liver metastasis: two cases report
Authors: Martino Celine , Tendean Michael , Mambu Toar Deliezer Bram , Tjandra Ferdinand , Iskandar Michael
Published: February 2022

Background:Â Colorectal cancer (CRC) is ranked as the third most common cancer worldwide.One ofÂ the leading causes of death in CRC patients is due to its metastasis. The liver is the most common site of metastasis.Â The best treatment to achieve long-term survival and cure patients with CRC liver metastasis is surgery, whether itâ€™s sequential, delayed, or simultaneous resection.This case study aims to evaluate the simultaneous resection on the patient with synchronous colorectal liver metastasis.Case Presentation:Â From January-June 2020, in Prof. Dr. R. D. Kandou General Hospital, Manado, 2 patients were treated with simultaneous resection for CRC with resectable synchronous liver metastasis. Blood loss, bile leak, ascites, and post hepatectomy liver failure (PHLF) were observed asÂ outcome parameters.Conclusion:Â Simultaneous resection is safe and exhibits advantages in the long-time survival of patients.Â However, the incidence of complications and mortality are higher in simultaneous resection than in staged resection.
Patientsâ€™ characteristics following reoperation after Modified Blalock-Taussig Shunt (MBTS) in Cardiac Centre National General Hospital Cipto Mangunkusumo from 2018-2020
Authors: Wardoyo Suprayitno , Pardede Joshua Parsaoran Partogi , Asari Hari Agung
Published: February 2022

Background: Modified Blalock-Taussig shunt (MBTS) is a common palliative procedure for congenital heart defect to connect the systemic to the pulmonary circulation via a synthetic shunt from a subclavian artery to a pulmonary artery. However, certain postoperative complications do exist, such as blockage. Early identification of modifiable risk factors is important to prompt early intervention for better outcomes.Material: This article is a descriptive narrative retrospective study. We gather data from the Cipto Mangunkusumo Hospital Cardiovascular Center medical report of 8 patients having undergone reoperation post-MBTS surgery as their first operation between January 2018 and October 2020. Data were analyzed using SPSS version 20 for Windows.Results: The patientâ€™s age ranged from 3 months to 30 years old. Seven of them suffered from shunt occlusion complications, while the other suffered from the bleeding problem. The laboratory results showed that preoperative hemoglobin (18.9Â±4.1 g/dL vs. 16.90 (10.80-19.20) g/dL), hematocrit (58.8Â±12.40% vs. 42.9Â±14.30%), platelet counts (284.487Â±147.003 vs. 210.625Â±104.688) 103/uL, and oxygen saturation (86.00 (75.00-89.00) vs. 70.00Â±17.00) levels were higher than the pre-reoperative. The coagulation markers showed that PT value has increasing trend (1.10 (0.90-2.30) vs. 1.30Â±0.20) while aPTT (5.90 (2.90-6.30) vs. 2.30 (1.60-5.30)) seconds and activated clotting time (ACT) (205.00Â±86.00 vs. 165.00 (114.00-255.00)) showed the opposite.Conclusion: MBTS remains the first-choice bridging palliation surgery to increase the pulmonary blood flow in congenital heart defects. The cause of shunt failure remains inconclusive in this study. Other studies suggest that graft material choice, S/PA ratio, S/W ratio, operative approach, thrombus formation, and aPTT value contribute to shunt failure, thus needing a reoperation.
Penile gangrene as a priapism sequele due to Chronic Myeloid Leukemia (CML): the first report in Indonesia
Authors: Yulizar Deddy Rasyidan , Maulani Eka Putri , Prasetya Heru , Sutapa Hendra , Rahman Eka Yudha
Published: February 2022

Background: Priapism is defined as a prolonged erection of the penis lasting over 6 hours in the absence of sexual stimulation. Priapism is divided into two types, Low-Flow (ischemic priapism) and High-Flow (trauma). This case study aims to evaluate penile gangrene as a priapism sequele due to Chronic Myeloid Leukemia (CML) as the first report in Indonesia.Case Presentation: A 45-years old male patient admitted at Muara Teweh hospital before referred to Ulin Hospital presented with Fournier gangrene with unconfirmed leukemia as comorbidities used in this case report. In his medical history, â€œSnake Maneuver Shuntingâ€ has been carried out in this patient as an indication for priapism lasting more than 24 hours.Conclusion: Hyperleukocytosis is thought to be the cause of priapism in patients with leukemia. Leukostasis is the most common medical emergency seen on CML patients in blast crisis.
The effects of cyclophosphamide, adriamycin and 5-fluorouracil chemotherapy on blood cells and cardiac hemodynamics in breast carcinoma patients: a case study at Dr. Kariadi General Hospital, Semarang, Indonesia
Authors: Chandra Sibin , Handojo Djoko
Published: February 2022

Background: One of the treatment modalities for breast malignancy is chemotherapy. Chemotherapy could kill cancer cells as well as normal cells, including blood cells and cardiac cells. Early detection of adverse events includes myelosuppression and cardiotoxicity could reduce morbidity and mortality rates. This study aims to determine a decrease in blood cells and cardiac hemodynamics in breast carcinoma patients who underwent Cyclophosphamide, Adriamycin, and 5-Fluorouracil (CAF) chemotherapy.Methods: Analytical prospective observational study with breast carcinoma. The measurements were Haemoglobin (Hb), Hematocrit (Ht), Erythrocyte (Ery), Leukocyte (Leu), Platelet (Plt), Left Ventricle Ejection Fraction (LVEF), Stroke Volume (SV), and Cardiac Output (CO) until 3rd cycles of chemotherapy. Data were analyzed using SPSS version 17 for Windows.Results: There were 35 subjects enrolled in this study. Decreases in Hb, Ht, Ery, Leu, and Plt after the 1st, 2nd, and 3rd cycles of chemotherapy were statistically significant (p<0.05). There was a statistically significant decrease in LVEF, SV, and CO after the 1st, 2rd and 3rd cycles of chemotherapy (p<0.05). Besides, the SV and CO after the 2nd and 3rd cycles of chemotherapy were also decreased significantly (p<0.05).Conclusions: There is a decrease in blood cells (Hb, Ht, Ery, Leu, Plt) and cardiac hemodynamics (LVEF, SV, and CO) in breast carcinoma patients who underwent CAF chemotherapy.
Comparison of skin hydration degrees based on moisturizing time in children's atopic dermatitis
Authors: Wulandari Puteri , Lubis Syahril Rahmat , Paramita Deryne Anggia
Published: February 2022

Background: Atopic dermatitis (AD) is a skin disease accompanied by an inflammatory reaction influenced by heredity and environment. Atopic dermatitis commonly occurs in infants and children. Overcoming dryness of the skin is an important strategy in the management of AD. One way is by using a moisturizer (emollient) to increase the skin barrier function. This study aimed to compare the degree of skin hydration based on moisturizing time in children with AD, immediately after bathing and 30 minutes after bathing.Methods: This analytical study's design was quasi-experimental (pre-post clinical trial) conducted in dermatology-venereology policlinic of Universitas Sumatra Utara Hospital. Subjects who met inclusion criteria were children with AD, 2-14 years who met William's criteria,Â  no recent use of topical preparations, and informed consent approved. The bath soap and moisturizer used were Johnson'sÂ® baby milk soap and those containing ceramide-3 (AtocalmÂ®), respectively, applied twice a day.Â  Moisturizing time is given immediately and 30 minutes after bathing on the volar part of the right forearm and left forearm, respectively. The degree of skin hydration was measured by Corneometer CM 825Â®, taken four times on the 1st, 8th, 15th, and 21st day, and categorized into very dry skin, dry skin, and normal skin.Â  Test analysis using SPSS software with p<0.05 was significant.Result: Thirty-seven children with AD followed this study. The median age was 5 (2-13) years, female sex (21 children [56.8%]). There were differences in skin hydration between these groups. There was also significant right forearm volar skin hydration measured immediately after bathing, 1st, 8th, 15th, 21st day (42.3; 48.0; 55.3; 61.3 AU (Arbitrary Unit); p<0.001), respectively. Skin hydration on the left forearm's volar part is significant between 30 minutes after bathing, respectively 1st, 8th, 15th, 21st day (42.3; 44th,7th; 47.7; 52.0 AU; p<0.001). The total amount of dry skin and very dry skin was more in the moisturizing group 30 minutes after bathing than immediately after bathing.Â Conclusion: Significant difference in skin hydration degrees found between immediately after the bathing group (on the right forearm volar) and 30 minutes after bathing (on the left forearm volar).
Melatonin prevented the increased serum lactate levels and the reduced hemoglobin levels in burn-induced Wistar rats
Authors: Dhea Graciela , Utami Sulistiyati Bayu , Fulyani Faizah , Kresnoadi Erwin , Wicaksono Satrio Adi
Published: February 2022

Background: Burns are the most common and devastating form of trauma yet constitute a common cause of morbidity worldwide. Complications of burns such as sepsis and tissue hypoperfusion may increase serum lactate and reduce hemoglobin. Measuring lactate levels has been proven to be a useful predictive marker of hypoperfusion and sepsis in patients with burns. Melatonin which acts as an anti-inflammatory and antioxidant, has been proposed to be used as pharmacological adjuvant in patients with burns, reducing oxidative damage. The study aims to investigate the effects of melatonin supplementation on serum lactate and hemoglobin levels in burn-induced male Wistar rats.Method: This was an experimental animal study with randomized control group design. All samples (n=12 male Wistar rats) were randomized and divided into two groups. Each rat was exposed to a hot metal rod for 10 seconds to induce 30% burns injury. Rats in the control group were administered with placebo (aquadest), while rats in the experimental group were administered with melatonin intraperitoneally at 0, 8, and 16 hours after burns injury. Blood samples were collected from the retro-orbital sinuses at 0, 3, and 24 hours after treatment. Data were statistically analyzed using Paired t-Test, Independent t-Test Mann-Whitney Rank Test and Wilcoxon test.Results: There were no significant differences in lactate and hemoglobin levels between melatonin group and control group 0 hours after treatment (T0), 3 hours after treatment (T3), and 24 hours after treatment (T24) (p>0.05). There were increased lactate levels and decreased hemoglobin levels in both melatonin and control groups, however the increment of lactate and the decrement of hemoglobin were steeper in control group compared to melatonin group. There were higher serum lactate increments and higher hemoglobin decrement at 24 hours (âˆ†T0â€“T24) in control compared to melatonin group (p<0.05).Conclusion: Melatonin might prevent dramatic rise of serum lactate levels and decrease of hemoglobin levels until 24 hours after treatment in burns injury. If confirmed by further studies, melatonin might have a role as adjuvant therapy in burns.
The relationship between the brain gym and the changes in interleukin 6 levels and the cognitive function in the elderly
Authors: Juswanto Gerard , Rahmawati Dani , Husni Amin , Widiastuti Widiastuti , Kustiowati Endang , Suryawati Herlina , Pudjanarko Dwi
Published: February 2022

Background: The prevalence of cognitive impairment increased by 10% that is doubling every 20 years. Brain gym is one of the non-pharmacological cognitive stimulation therapies that effectively increases brain neuroplasticity and is easy to do. The interleukin 6 biomarker is a pro-inflammatory blood marker that is sensitive to cognitive impairment. This research aims to analyze the relationship between the brain gym and the changes in interleukin 6 levels and the cognitive function in the elderly.Methods: This research is a quasi-experimental observational study with a pretest and post-test approach without controls. The subjects are the elderly from the Tresna Werdha Social Home, Semarang. For comparative hypothesis test between categorical and numerical scale variables, normal data distribution was conducted by Independent T-test.Results: In this research, 33 subjects had the average age of 70.06 Â± 6.43 years and the dominant sex was male. There was a significant difference between interleukin 6 levels in pre and post brain gym (p<0.001). There was also a significant difference between the MoCA-Ina values in pre and post brain gym (p<0.001).Conclusion: Interleukin 6 levels decreased after doing brain gym compared to before while the MoCA-Ina value increased after doing brain gym compared to before. Brain gym is safe, easy to do, and effective as a non-pharmacological therapy of neuroplasticity in cognitive impairment.
Correlation between nail psoriasis severity index score with quality of life in nail psoriasis
Authors: Arif Abdul , Roesyanto Mahadi Irma Damayanti , Yosi Ariyati
Published: February 2022

Background: Psoriasis is a recurring chronic inflammatory disease, which can involve the skin, nails and joints. Nail psoriasis occurred in 50% of psoriasis patients. Nail psoriasis can interfere with the quality of life (QoL) due to its physical, mental, and social impacts. To determine the correlation between Nail Psoriasis Severity Index (NAPSI) score and QoL in nail psoriasis patients.Methods: This was a correlative analytical study with a cross-sectional approach that involved nail psoriasis subjects aged â‰¥18 years. Data accessed from the recording of basic data. The examination of subjects included an assessment of NAPSI scores and the Nail Psoriasis Quality of Life (NPQ10) questionnaire. Statistical analyses were performed using Pearsonâ€™s correlation coefficients, with P<0.05 was considered statistically significant.Results: A total of 26 subjects with nail psoriasis, with the highest proportion, were female (57.7%), age group of 48â€“57 years (34.6%), duration of psoriasis >5 years (76.9%), NAPSI score 81-100 (30.8%), the mean NAPSI score was 89.42Â±32.01, and the mean NPQ10 score was 6.96Â±3.30. There was a significant moderate positive correlation between the NAPSI score and QoL (r=0.632, p=0.001).Conclusion: The higher the NAPSI scores, the worse the quality of life for nail psoriasis patients.
Fractional erbium: YSGG laser compared to the combination of fractional erbium: YSGG laser and topical autologous platelet-rich plasma for treatment of atrophic acne scars: a case report
Authors: Mawardi Prasetyadi , Nareswari Adniana
Published: February 2022

Background: Acne scar is the most common complication in acne that occurs in about 49% of acne individuals. Fractional resurfacing lasers such as CO2 laser and erbium-doped yttrium aluminum garnet (Er: YAG) have been widely used for acne scar treatment and give satisfying results have complications such as pain, hyperpigmentation, infection, prolonged erythema, and scarring. Fractional erbium: yttrium scandium gallium garnet (Er: YSGG) laser solves previous laser techniques' disadvantages. It has an ideal wavelength of 2790 nm, which balances the epidermis layer's vaporization and thermal damage in the dermis's superficial layer. Platelet Rich Plasma (PRP) is an autologous concentration of human platelets in a small plasma volume that secreted various growth factors that can speed up the scar healing process.Case report: A-24 years old male student came with a chief complaint of acne scars on his face four years before the examination. The patient's condition is classified as moderate-severe acne scarring based on Goodman and Baron's criteria (qualitative global acne scarring system). Acne scars treatment plan was single fractional erbium: YSGG laser for the left side of the face and combined fractional Er: YSGG laser with topical autologous PRP on the right side. This procedure was performed in 2 sessions with an interval of 4 weeks, the final evaluation at 12 weeks after the first procedure. Clinical improvement of acne scars was assessed using qualitative and quantitative scales based on Goodman and Baron's, patient and observer scar assessment scale (POSAS), quartile grading scale, and patient satisfaction level.Conclusion: In the final evaluation, there was an improvement on the entire grading scale on the right side of the face (Er: YSGG laser + PRP) and the face's left side (Er: YSGG laser only). Post-treatment erythema was found on both sides of the patient's face but disappeared within three days on the face's right side and five days on the face's left side.
Difficulties in establishing a definitive diagnosis of intracerebral hemorrhage in patients with HIV/AIDS
Authors: Bakhtiar Yuriz , Arifin Muhamad Thohar , Pratama Adrian
Published: February 2022

Introduction: Neurological disorders are observed in about 70% of HIV/AIDS cases, of which intracranial mass lesions characterize 10-20%. In addition, the incidence of intracerebral hemorrhage is frequently associated with several etiologies, including toxoplasmosis and cerebral tuberculosis. This manifestation has been attributed the most common opportunistic infections in developing countries. Therefore, a CT scan of the head is commonly used to provide similar images, and consequently mimic SOL or general brain tumors. Meanwhile, laboratory examinations merely use rapid tests without any serologic assessment for opportunistic infections, which prompts difficulties in the confirmatory diagnostics process.Method: This paper reports two HIV/AIDS cases with neurological disorders. The first involved two patients with multiple SOLs, while the second was a patient with both SOL and intracerebral hemorrhages. Furthermore, the difficulties in establishing an SOL diagnosis by merely relying on head CT scans are observed in these reports, as only toxoplasmosis and tuberculoma were detected. The dilemma of performing a brain biopsy has also been considered an impeding factor.Conclusion: intracerebral hemorrhage is prevalent and is also considered another cause of neurological disorders and is still a challenging diagnosis in person with HIV/AIDS.
Predicting factors for walking ability of postoperative patients with hemiarthroplasty at Wahidin Sudirohusodo Hospital in Makassar
Authors: Sakti Muhammad , Saleh Ruksal , Yudha Khrisna , Akbar Taufiq
Published: February 2022

Background: The ability to make early predictors in post-surgery includes health workers preparing patients for outpatient care. The purpose of this study is to determine the factors that influence the ability to walk postoperative hemiarthroplasty patients when patients are admitted. We hypnotized that age, sex, preoperative walking status, time interval between injury to surgery, preoperative hemoglobin level, muscle weakness, muscle atrophy, anxiety level and body mass index would be predictive factors for walking ability post hemiarthroplasty surgery.Method: An descriptive-analytic study with a cross sectional retrospective approach was conducted at the Wahidin Sudirohusodo Hospital in Makassar 2020. Patients with fractures of the proximal femur had undergone hemiarthroplasty surgery and were over 50 years of age at admission from September 2019 to October 2020. Bivariate and multivariate with logistic regression was usedResult: 39 samples according to inclusion criteria were analyzed. Muscle atrophy has a significant correlation with p = 0,04 (p<0,05). Body mass index and muscle atrophy have the most dominant factors for predict walking ability post hemiarthroplasty (EXP (B) 7,282 & EXP (B) 0,083) eventhough not significant statistically (p = 0,116 & p = 0,073)Conclusion: The muscle atrophy variable in this study was the most significant factor in prediction walking ability post hemiarthroplasty surgery. Also, patient with normal BMI will encourage early walk after surgery better than abnormal BMI in the same muscle-wasting condition