bluuebunny/crossref_metadata_2025 huggingface dataset:
Incidence of ischemic complications and technical nuances of arteries protection for insular gliomas resection.
Authors: Hou Zonggang , Huang Zhenxing , Li Zhenye , Li Gen , Xu Yaokai , Wang Mingran , Sun Shengjun , Zhang Yazhuo , Qiao Hui , Xie Jian
Published: March 2021

Insular gliomas remain surgically challenge due to their complex anatomical position and microvascular supply. The incidence of ischemic complications is a risk that should not be ignored. The goal of this study was to analyze the incidence of ischemia and its risk factors, and also describe a single surgeon's arteries protection experience of insular gliomas resection. The authors studied 75 consecutive cases of insular gliomas that underwent transcortical tumor resection in their division. Analysis included pre- and postoperative demographic, clinical, radiological including diffusion weighted imaging (DWI), as well as intraoperative neurophysiology data, and functional outcomes. Strategies such as “Residual Triangle”, “Basal Ganglia Reconstruction” and “Sculpting Technique” were used to protect lateral lenticulostriate arteries and main branches of M2 for maximal tumor resection according to the different classification of Berger-Sinai. Postoperative diffusion-weighted imaging showed acute ischemia in 44 patients, only 9 of whom developed new motor deficits. Flat inner edge (OR 0.144 95% CI 0.024, 0.876), and motor evoked potentials (MEPs) (<50%) (OR 18.182, 95% CI 3.311, 100.00) were determined to have significant associations with postoperative Critical Ischemia, which located in the posterior limb of the internal capsule or corona radiata. For insular gliomas resection, the protection of main branches of MCA is important. Insular gliomas resection might be with high incidence of ischemia uncovered by DWI which not always result in neurological deficits. Their own strategies maybe the feasible technical nuances allow the surgeon to achieve a thorough and safe resection. Motor evoked potentials is essential for its resection.
Comparison of Times of Synchronization of Chaotic Burke-Shaw Attractor with Active Control and Integer and Optimum Fractional-Order Pecaro Carroll Method
Authors: Durdu Ali , Uyaroğlu Yılmaz
Published: March 2021

Many studies have been introduced in the literature showing that two identical chaotic systems can be synchronized with different initial conditions. Secure data communication applications have also been made using synchronization methods. In the study, synchronization times of two popular synchronization methods are compared, which is an important issue for communication. Among the synchronization methods, active control, integer, and fractional-order Pecaro Carroll (P-C) method was used to synchronize the Burke-Shaw chaotic attractor. The experimental results showed that the P-C method with optimum fractional-order is synchronized in 2.35 times shorter time than the active control method. This shows that the P-C method using fractional-order creates less delay in synchronization and is more convenient to use in secure communication applications.
Idiopathic Pulmonary Fibrosis and Diabetes Mellitus: A Meta-Analysis and Systematic Review
Authors: Bai Le , Zhang Li , Pan Tingyu , Wang Wei , Wang Dian , Turner Cassidy , Zhou Xianmei , He Hailang
Published: March 2021

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse interstitial lung disease, of which the etiology has been poorly understood. Several studies have focused on the relationship between IPF and diabetes mellitus (DM) in the past years but have failed to reach a consensus. This meta-analysis aimed to examine the association between diabetes to IPF.Methods: We accumulated studies investigating the association between DM and IPF from databases including Medline, Cochrane Library, Embase, Web of Science, and China National Knowledge Infrastructure. RevMan 5.3 and the Newcastle-Ottawa Scale (NOS) were utilized to analyze the data and assess the quality of the included studies. The value of odds ratio (OR) with 95% confidence interval (CI) was used as the measure to estimate the risk of DM in IPF. Heterogeneity was assessed by I2 statistics. We also performed subgroup analysis, meta-regression, and Egger’s test for bias analysis. Results: Nine case-control studies with 5,096 IPF patients and 19,095 control subjects were included in the present meta-analysis, which indicated that DM could increase the risk of IPF (OR: 1.65, 95% CI: 1.30-2.10; P < 0.0001). Meta-regression and subgroup analysis negated the influence of covariates like cigarette smoking, age and gender, but the heterogeneity existed and could not be fully explained. Conclusion: The meta-analysis indicated that DM is highly probably related to IPF. Further rigorously designed studies are required to confirm the present findings and investigate the possible mechanisms behind the effect of DM on IPF.
Prognostics significance of small pulmonary vessels alteration measured by chest CT in connective tissue diseases with PAH
Authors: Zhang Yue , Zhang Ning , Sun Xiaoxuan , Liu Qingwen , Yuan Xiaohan , Wang Qiang , Zhou Lei
Published: March 2021

Background

Pulmonary arterial hypertension (PAH) is characterized by structural alterations of the pulmonary vessels. Few studies have explored the clinical significance of quantitative assessment of pulmonary small vessels by chest CT. Our aim was to assess whether the prognosis of connective tissue diseases (CTD)-PAH patients could be asscessed through pulmonary small vessels measured by chest CT.
Methods

42 CTD-PAH patients diagnosed based on right heart catheterization were retrospectively investigated. All patients underwent a chest CT within 1 month before and after RHC examination. Main pulmonary artery (MPA), the cross-sectional area of small pulmonary vessels < 5 mm 2 as a percentage of total lung area (%CSA< 5) were measured. The primary endpoint was a composite clinical worsening endpoint.
Results

After a median follow-up time of 30.5 (IQR, 8.5-45.25) months, endpoint events occurred in 16 (38.1%) patients after 19.5 (IQR 10.0-45.5) months. Cox univariate proportional hazard analysis showed that pulmonary vascular resistance, MPA diameter, and %CSA< 5 were associated with the endpoint. A combination of MPA diameter and %CSA< 5 was the independent risk factor for the prognosis (hazard ratio, 2.180 [95% CI, 1.405–3.383], P = 0.001). Kaplan-Meier analysis showed that CTD-PAH patients satisfying %CSA< 5 less than 0.382 and MPA greater than 36.75 mm had the highest risk of experiencing the endpoint.
Conclusion

Among the pulmonary vascular indicators measured by chest CT, in addition to MPA, %CSA< 5 may be a potential independent risk factor for poor long-term prognosis in Chinese CTD-PAH patients.
Aedes Aegypti: Morphology the Egg and Embryonic Development
Authors: Mundim-Pombo Ana Paula Miranda , León Marisol , Carvalho Hianka Jasmyne Costa de , Maria Durvanei Augusto , Miglino Maria Angelica
Published: March 2021

Background: Aedes aegypti (Diptera: Culicidae) has great relevance in public health worldwide due to its performance as a vector of arboviruses, which makes the knowledge about its cycle fundamental. It is known that the acquaintance of embryonic kinetics has great potential to assist in the development of new vector control technologies and, consequently, in the control of arboviruses. Methods: This research proposes to analyze the egg morphology and embryonic development of Aedes aegypti. Eggs from the insectary of the Institute of Biomedical Sciences of the University of São Paulo (n = 46) were used. The methodological procedure involved morphological and ultrastructural analyzes using equipment for optical microscopy (light and confocal) and electronic (scanning). Eggs and embryos were observed in initial, intermediate and final thirds of development, kept at a temperature of 28°C, 1°C until collection for processing. Results: The embryos had different morphological characteristics according to the stage of gestation, in the initial and intermediate stages of development. In the initial third, the presence of primordial epithelium and characteristics suggestive of intense cellular activity were found. Conclusion: According to the results obtained in the eggs, it is concluded that the great resistance of the chorion in the embryo is a factor that generates difficulties for microscopic analysis of the embryo (mainly in fixation), with a strong protective barrier.
A high positive correlation between the distance and temperature of the hottest nearby space objects
Authors: Kalhor Bahram , Mehrparvar Farzaneh , Kalhor Behnam
Published: March 2021

The paper uses the distance and temperature of 47,111 hottest nearby space objects including stars, quasars, white dwarf, and carbon stars. We have used SIMBAD Astronomical Database and obtained this information from 930,000 records. The range of temperature of the hottest objects is between 6158 and 99,575 K. Also, the distance of the objects is between 231.7375 and 1 (mas). We report the correlation between the distance and temperature of these hot objects at the temperature upper than 6632 K is equal to 0.135063 and will be increased to 0.32001 at temperatures upper than 9860 K. Also, the correlation between the temperature and distance of objects hotter than 12,000 K is equal to 0.270218.
Determinants of Acculturation Preferences between Ethiopian Majority in Shashemene, and Rastafarian Community
Authors: Badasa Gamachu Gishe , Bedada Mekonnen Sime
Published: March 2021

Background

Acculturation is learning and adopting cultural traits different from the ones with which the person was originally growing up.
Methods

The researchers employed a transformative mixed research design. We randomly selected 349 participants from both the majority and their counterparts. Item measures acculturation choices of native and Rastafarians which were adapted from Navas et al. (2005) Relative Acculturation Extended Model. We computed multinomial logistic regression analysis to identify determinants of majorities' and minorities' acculturation preferences. A p-value < 0.05 considered significant.
Results

The study has shown that most of the respondents preferred the marginalization approach 54.7%. This result also highlighted that the second-largest preferred acculturation was assimilation 22.6%. Over 26.8% of the Rastafarians, pick separation preference. in the condition where the Rastafarians were to speak the local language, their likelihood of making integration to marginalization increased by 0.37 unit while holding all other variables in the model constant (AOR = 0.374, 95% CI (.146,.959). If a majority were to increase smoking Ganja by one point, the odds of preferring integration to marginalization enhanced by 0.008 points (AOR = 0.008, 95% CI (.001, 072). As for factors related to Rastafarians’ acculturation decision, divorce is one factor because many Ethiopian women who have a relationship with local men marry and bear children to Rasta men just to share their resources. In this study, the likelihood of making integration to marginalization optimized by 41.95 points if the local people had the habit of smoking Ganja (AOR = 41.95, 95% CI (2.51,.701.69). The Rastafarian reported that the town leaders have been continuously accusing them of planting and smoking Ganja, marijuana, and others.
Conclusion

The research suggested that there are some individuals working against the Rastafarians; therefore, elders and Abba Gedas have to work together to protect the vulnerable group as the Oromo culture, nurture togetherness and peaceful coexistence not to displace their neighborhood. We found that the Rastafarian people lack unity among themselves because there are some individuals often creating problems and paving the way for other intruders to discriminate against the Rasta community. Therefore, before blaming others it is a good idea if you first clean your houses.
Highly Sensitive Terahertz Non-destructive Testing Technology for Stone Relics Deterioration Prediction Using SVM-Based Machine Learning Models
Authors: Meng Tianhua , Huang Rong , Lu Yuhe , Liu Hongmei , Ren Jianguang , Zhao Guozhong , Hu Weidong
Published: February 2021

The hollowing deterioration of stone relics required effective non-destructive testing (NDT) methods for their timely restoration and maintenance. To this end, a new NDT method based on terahertz (THz) technology by using support vector machine (SVM)-based machine learning models was developed to assess and diagnose the hollowing deterioration of the Yungang Grottoes. According to experiment design, a series of hollowing deterioration samples with various thicknesses of hollowing deterioration were prepared and then measured by using THz time-domain spectroscopy (THz-TDS). Based on the THz-TDS results of 30 randomly selected samples, a SVM-based hollowing deterioration prediction model (SVM-HDPM) was established by analyzing the relationship between the hollowing samples and the THz spectral information. The reliability and accuracy of the model was further proved by verified and compared with using the THz spectral data of the remaining 10 samples. The experimental results with the linear kernel function greatly demonstrated that the SVM-HDPM can have superior prediction accuracy with a mean square error (MSE) of 3.303E-4, implying that the model is feasible for the prediction the hollowing deterioration of the stone relics. Moreover, one data preprocess was introduced into SVM-HDPM to meet the needs of field-based test. The predicted results of five different hollowing deterioration with different flaked stone thickness revealed good performance with MSE value as low as 4.46E-4. Therefore, it is believed that the proposed method can be regarded as an effective NDT technique with practical applications in analyzing cultural relics and have promising future prospects in inspection stone relics-like ancient heritage for hidden flaws.
Cytotoxicity and Toxicological Studies of Artocarpus altilis Extracts,
Inducing Apoptosis and Cell Cycle Arrest via CASPASE-3 and CASPASE-8 Pathways against Human Breast MCF-7 Cells
Authors: Jalal Tara , Natto Hatim Abdullah , Wahab Ridhwan Abdul
Published: March 2021

Background:

In recent biomedical research, the area of cancer and infectious diseases occupies a leading position in the utilization of medicinal plants as a source of drug discovery. Malaysia has a diversity and a large number of underutilized fruits that are rich in phenolic compounds. Artoarpus altilis is considered an underutilized fruit that is rich in phenolic compounds. Methanol extracts of A. altilis have been previously found to contain a high content of antioxidant phytochemicals.

Objective:

The purpose of the study was to evaluate the cytotoxicity and toxicological effect of methanol fruit extracts against MCF-7 cells. To determine the least concentration that might kill or suppress the growth of the cancer cells was in a concentration-dependent manner.

Methods:

The variation in the cytotoxic activity among the extracts was indicated by determining the IC50 of each extract against cells at 72 h. The IC50 of the samples was measured using a trypan blue exclusion assay. The methanol extract of the pulp part showed the least inhibition concentration of 15.40±0.91 μg/mL on MCF-7 cells. In the study, the molecular mechanism of methanol extracts-induced apoptosis and cell cycle arrested in human cancer cells were investigated in a time-dependent-manner by using flow cytometry. The treated cells were stained with nexin to detect early and late apoptosis and with propidium iodide (PI) for cell cycle arreste associated with the DNA fragmentation; various cell arrests occurred at G1/S, S, and G2/M phases. Lastly, the gene expression analysis by RT-qPCR method was carried out by analyzing the expression of the gene of interest for the quantification of mRNA levels.

Results:

Results after cells were treated with IC50 were revealed by upregulating anti-apoptotic genes/downregulated of pro-apoptotic BCL-2 gene expressions triggered the treated cells into CASPASE-3, intrinsic and extrinsic pathways.

Conclusion:

These findings suggest that the methanol extracts of three parts of A. altilis fruit have potential anticancer activity against MCF-7 cells mainly the pulp part of the fruit.
Antimycobacterial Assessment and Microwave-assisted Synthesis of 2-aryl-
3-(4-methylphenylamino)thiazolidin-4-one Derivatives
Authors: Alghamdi Saad , Kamal Mehnaz , Asif Mohammad
Published: March 2021

This article reports the microwave-assisted synthesis, characterization, and evaluation of some -4-one derivatives (2a-2h) for their in-vitro antimycobacterial activities against Mycobacterium tuberculosis H37Rv strain by microplate Alamar blue assay (MABA) method. All these final compounds (2a-2h) were synthesized from Schiff’s bases, 1-arylidene-2-(4-methylphenyl)hydrazines (1a-1h), and thioglycolic acid by using zinc chloride as a catalyst. Compounds (1a-1h) were synthesized from the reaction of 4-methylhydrazine and appropriate aromatic aldehydes by Schiff’s reaction. Among the target compounds, 2-(4-ethoxyphenyl)-3-(4-methylarylamino)thiazolidin-4-one (2f) and 2-(4-ethylphenyl)-3-(4-methylarylamino)thiazolidin-4-one (2g) were promising with a minimum inhibitory concentration (MIC) of 12.5 μg/mL against M. tuberculosisH37Rv. Based on the preliminary results, compounds 2f and 2g were considered as lead compounds for the advanced design and development of antimycobacterial agents.
Calculation of the dependence of friction coefficient of locomotive composite ridge brake shoes on pressing force and braking speed
Authors: Gabidullin A. E. , Gorskiy D. V. , Nazarov I. V. , Nikitin V. A.
Published: February 2021

JSC “FRITEX” has developed non-asbestos ridge composite brake shoes UR 01-01 with a reduced coefficient of friction, which, in contrast to the cast iron ridge brake shoes currently used on locomotives, have high wear resistance and more stable frictional properties at high speeds. They are much lighter than traditional cast iron shoes, resulting in lower logistics costs and easier replacement by service departments. However, the new materials used for the production of the shoe, as well as its innovative design, which combines the two types of materials, require a detailed study of its frictional properties. For this, the braking modes of a locomotive equipped with UR 01-01 shoes were simulated in a full-scale unit of a brake mechanism on an inertial stand at fixed pressures and speeds. Based on the results of the experiments, the values of the friction coefficients of the brake shoes were determined and the dependence of the friction coefficient of the shoes on the pressing force and braking speed was established. The data obtained were used in braking calculations for an electric locomotive of the VL80 series, including the determination of the braking distance, holding a single locomotive by the parking brake on a slope, and ensuring the antiskid braking due to higher values of the friction coefficient of the UR 01-01 shoe at high speeds. The composite ridge brake shoe ensures compliance with the standard values of the braking distance, antiskid braking and slope parking for the VL80 series electric locomotive. In this case, the use of these composite shoes is possible without changes in the device of the lever transmission of the electric locomotive. It is necessary to conduct running brake tests to make approbation of obtained empirical dependence of the friction coefficient of new shoes on the pressing force and the braking speed of the locomotive and its widespread use in the calculation of brake systems.
Aksilarna kirurgija u liječenju invazivnog karcinoma dojke
Authors: Car Peterko Ana
Published: March 2021

U posljednjih nekoliko desetljeća prisutan je konstantan trend deeskalacije aksilarne kirurgije u liječenju invazivnog karcinoma dojke. Početkom stoljeća biopsija sentinel limfnog čvora postaje zlatni standard i do danas gotovo potpuno zamjenjuje aksilarnu disekciju kod liječenja ranog stadija raka dojke. Istraživanja koja su u tijeku pokušavaju utvrditi postoji li u ovoj populaciji opravdanost ikakvog kirurškog postupka u aksili. Istovremeno se šire indikacije za preoperativno sistemsko onkološko liječenje, međutim, sve do 2017. godine vrlo je konzervativan kirurški pristup u okviru neoadjuvantnog liječenja, s aksilarnom limfadenektomijom kao jedinom opcijom. Iako je biopsija limfnog čvora čuvara nakon neoadjuavntnog liječenja već tri godine preporučena svim relevantnim smjernicama za liječenje karcinoma dojke, još uvijek je prisutan velik otpor u prihvaćanju ovog koncepta u svakodnevnu kliničku praksu. Ovaj pregled je prikaz znanstveno utemeljenog razvoja smjernica u aksilarnoj kirurgiji, postojećih kontroverzi i istraživanja koja ih pokušavaju riješiti.
Improving Human Happiness Analysis Based on Transfer Learning: Algorithm Development and Validation (Preprint)
Authors: Yu Lele , Zhang Shaowu , Zhang Yijia , Lin Hongfei
Published: February 2021

BACKGROUND

Happiness refers to the joyful and pleasant emotions that humans produce subjectively. It is the positive part of emotions, and it affects the quality of human life. Therefore, understanding human happiness is a meaningful task in sentiment analysis.

OBJECTIVE

We mainly discuss 2 facets (Agency/Sociality) of happiness in this paper. Through analysis and research on happiness, we can expand on new concepts that define happiness and enrich our understanding of emotions.

METHODS

This paper treated each happy moment as a sequence of short sentences, then proposed a short happiness detection model based on transfer learning to analyze the Agency and Sociality aspects of happiness. First, we utilized the unlabeled training set to retrain the pretraining language model Bidirectional Encoder Representations from Transformers (BERT) and got a semantically enhanced language model happyBERT in the target domain. Then, we got several single text classification models by fine-tuning BERT and happyBERT. Finally, an improved voting strategy was proposed to integrate multiple single models, and “pseudo data” were introduced to retrain the combined models.

RESULTS

The proposed approach was evaluated on the public dataset happyDB. Experimental results showed that our approach significantly outperforms the baselines. When predicting the Agency aspect of happiness, our approach achieved an accuracy of 0.8653 and an F1 score of 0.9126. When predicting Sociality, our approach achieved an accuracy of 0.9367 and an F1 score of 0.9491.

CONCLUSIONS

By evaluating the dataset, the comparison results demonstrated the effectiveness of our approach for happiness analysis. Experimental results confirmed that our method achieved state-of-the-art performance and transfer learning effectively improved happiness analysis.
A Smartphone App for Engaging Patients With Catheter-Associated Urinary Tract Infections: Protocol for an Interrupted Time-Series Analysis (Preprint)
Authors: Bentvelsen Robbert Gerard , Veldkamp Karin Ellen , Chavannes Niels H
Published: March 2021

BACKGROUND

Catheter-associated urinary tract infections (CAUTIs) are the main cause of health care–associated infections, and they increase the disease burden, antibiotic usage, and hospital stay. Inappropriate placement and unnecessarily prolonged usage of a catheter lead to an elevated and preventable risk of infection. The smartphone app Participatient has been developed to involve hospitalized patients in communication and decision-making related to catheter use and to control unnecessary (long-term) catheter use to prevent CAUTIs. Sustained behavioral changes for infection prevention can be promoted by empowering patients through Participatient.

OBJECTIVE

The primary aim of our multicenter prospective interrupted time-series analysis is to reduce inappropriate catheter usage by 15%. We will evaluate the efficacy of Participatient in this quality improvement study in clinical wards. Our secondary endpoints are to reduce CAUTIs and to increase patient satisfaction, involvement, and trust with health care services.

METHODS

We will conduct a multicenter interrupted time-series analysis—a strong study design when randomization is not feasible—consisting of a pre- and postintervention point-prevalence survey distributed among participating wards to investigate the efficacy of Participatient in reducing the inappropriate usage of catheters. After customizing Participatient to the wards’ requirements, it will be implemented with a catheter indication checklist among clinical wards in 4 large hospitals in the Netherlands. We will collect clinical data every 2 weeks for 6 months in the pre- and postintervention periods. Simultaneously, we will assess the impact of Participatient on patient satisfaction with health care services and providers and the patients’ perceived involvement in health care through questionnaires, and the barriers and facilitators of eHealth implementation through interviews with health care workers.

RESULTS

To reduce the inappropriate use of approximately 40% of catheters (currently in use) by 15%, we aim to collect 9-12 data points from 70-100 patients per survey date per hospital. Thereafter, we will conduct an interrupted time-series analysis and present the difference between the unadjusted and adjusted rate ratios with a corresponding 95% CI. Differences will be considered significant when P<.05.

CONCLUSIONS

Our protocol may help reduce the inappropriate use of catheters and subsequent CAUTIs. By sharing reliable information and daily checklists with hospitalized patients via an app, we aim to provide them a tool to be involved in health care–related decision-making and to increase the quality of care.

CLINICALTRIAL

Netherlands Trial Register NL7178; https://www.trialregister.nl/trial/7178

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/28314
Social Networks Marketing in COVID-19 Epidemic Storm-A Case Study from Cultural and Creative Parks in Middle Taiwan
Authors: YEN Chia Sung
Published: February 2021

In order to attract more consumers, cultural and creative parks in Taiwan has launched new media marketing methods in recent years, hoping to attract more tourists. Starting in 2020, in the global COVID-19 epidemic storm, cultural and creative parks had tried so hard to keep customers’ concern. So they have strengthened the social networks links to social media. This study used group networks connection and qualitative methods, such as in-depth interview. Try to understand cultural and creative industries business promotion methods and effects.The results of this study found that starting from social networks is an important way to attract crowds, but there must be three supporting methods. 1) The function of social networks must be communicated with community groups to be effective. 2) Each marketing promotion must have certain issues before it can exert influence. 3) The characteristics of the topic must be combined with the local particularity.
Implementasi Metode Association Rule Mining Dengan Algoritma Apriori Untuk Rekomendasi Promo Barang
Authors: Christyan Putra Andreas Aditya , Haryanto Hanny , Dolphina Erlin
Published: March 2021

Perkembangan teknologi sangatlah cukup terasa bagi semua lini kehidupan tidak terkecuali dalam sektor dunia usaha perdagangan. Menjamurnya toko online merupakan salah satu dampak dari perkembangan teknologi yang merubah cara pola berpikir konsumen dalam bertransaksi. Walaupun banyak muncul toko online baru setiap tahun namun faktanya banyak juga toko online yang tidak bertahan lama, karena persaingan yang sangat ketat dan salah dalam strategi pemasaran. Kesalahan dalam promosi barang harus selalu diwaspadai oleh perusahaan supaya perusahaan tidak terlalu banyak mengeluarkan biaya promosi yang sebenarnya barang tersebut tidak disukai konsumen. Membaca pola transaksi konsumen merupakan salah satu cara dalam menghadapi masalah ini, oleh sebab itu pemanfaatan data mining tidak bisa dianggap remeh. Dalam proses data mining, metode asosiasi dengan algoritma apriori bisa menjadi solusi dalam masalah ini, dimana cara kerja algoritma ini yaitu mencari pola keterkaitan antar barang dari data transaksi penjualan, sehingga hasil dari penelitian ini dengan batasan minimal support 10% dan confidence 70% pada 30 data transaksi diketahui bahwa keterkaitan produk 34 dengan 33 sebesar 80% dan produk 49 dengan 51 sebesar 75% serta produk 51 dengan 49 sebesar 75% sehingga hasil informasi yang dihasilkan algoritma ini dapat dimanfaatkan dalam membuat sebuah promo barang yang sesuai oleh keinginan konsumen sendiri.
EKSISTENSI BRAHMAVIHARA ARAMA SEBAGAI DESTINASI WISATA EDUKASI DAN SPIRITUAL DI DESA BANJAR TEGEHA, KECAMATAN BANJAR, KABUPATEN BULELENG
Authors: Jayendra Putu Sabda , Sudiarta I Nyoman
Published: February 2021

Brahmavihara Arama yang berlokasi di Desa Banjar Tegeha, Kecamatan Banjar, Kabupaten Buleleng merupakan vihara Buddha terbesar di Bali. Vihara ini merupakan tempat suci yang diperuntukkan bagi umat Buddha yang didirikan sejak tahun 1969. Brahmavihara Arama merupakan salah satu destinasi wisata bernuansa religi, edukatif, dan spiritual yang banyak dikunjungi wisatawan mancanegara. Keberadaan vihara ini sangat unik dan menarik karena berada di tengah-tengah komunitas masyarakat Hindu Bali. Terlebih arsitektur vihara tersebut tidak sama dengan vihara yang bercorak kebudayaan Tiongkok, namun lebih dominan menggunakan arsitektur Bali. Fenomena ini tentu memiliki aspek historis dan filosofis yang sarat akan muatan edukatif. Fenomena lainnya adalah adanya aktivitas pelatihan meditasi yang melibatkan wisatawan mancanegara secara terstruktur yang terpusat di vihara ini. Hal tersebut menarik dan penting untuk dikaji lebih jauh, sehingga penelitian ini akan berfokus pada permasalahan materi edukasi yang disosialisasikan kepada wisatawan, serta aktivitas implementasi spiritualitas yang terjadi di Brahmavihara Arama. Penelitian ini mempergunakan Teori Interaksionisme Simbolik dan Teori Fungsionalisme Struktural dalam menganalisis permasalahannya. Hasil penelitian mengungkapkan bahwa aspek-aspek edukatif yang didapat wisatawan adalah toleransi (respect) dan filosofi pendakian spiritual melalui tahapan-tahapan dalam tiap struktur bangunan suci vihara yang dikunjungi. Sedangkan pola spiritualitas yang diterapkan pada wisatawan yang memang ingin mempelajari meditasi dilakukan secara bertahap. Tahap pertama adalah pengenalan ajaran Metta (kasih sayang universal), kemudian Samatha, yaitu melatih ketenangan melalui anapanasati, yaitu pengaturan napas. Setelah pengaturan napas dan posisi tubuh telah dikuasai barulah lanjut ke tahap Vipassana.
Artificial size selection experiment reveals telomere length dynamics and fitness consequences in a wild passerine
Authors: Pepke Michael , Kvalnes Thomas , Rønning Bernt , Jensen Henrik , Boner Winnie , Sæther Bernt-Erik , Monaghan Pat , Ringsby Thor Harald
Published: February 2021

Changes in telomere dynamics could underlie life-history trade-offs
among growth, size and longevity, but our ability to quantify such
mechanistic processes in natural, unmanipulated populations is limited.
We investigated how 4 years of artificial selection for either larger or
smaller body size affected early-life telomere length in two insular
populations of wild house sparrows. A negative correlation between
telomere length and structural size was evident under both selection
regimes. The study also revealed that male sparrows had longer telomeres
than females, after controlling for size, and there was a significant
negative effect of harsh weather conditions on telomere length. The
long-term fitness consequences of these changes in early-life telomere
length induced by the artificial size selection were explored over a
period of 11 years. These analyses indicated disruptive selection on
telomere length because both short and long early-life telomere length
tended to be associated with the lowest mortality rates and highest life
expectancy. There was also weak evidence for a negative association
between telomere length and annual reproductive success, but only in the
population where body size was increased experimentally. Our results
suggest that natural selection for optimal body size in wild animals
will affect early-life telomere length during growth, which is known to
be linked to longevity in birds, but also that the importance of
telomeres for long-term somatic maintenance and fitness is complex in a
wild bird species.
Engineered Lego®-like microphysiological models of the human airway clearance phenomena
Authors: Pedersoli Lucia , Zhang Shuaizhong , Briatico-Vangosa Francesco , Petrini Paola , Cardinaels Ruth , Toonder Jaap den , Pacheco Daniela
Published: February 2021

Mucociliary clearance is a crucial event that supports the elimination
of inhaled particles, bacteria, pollution and hazardous agents from the
human airways, and it also limits the diffusion of aerosolized drugs
into the airway epithelium. In spite of its relevance, few in vitro
models sufficiently address the cumulative effect of the steric and
interactive barrier function of mucus on the one hand, and the dynamic
mucus transport imposed by ciliary mucus propulsion on the other hand.
Here, ad hoc mucus models of physiological and pathological mucus are
combined with magnetic artificial cilia to model mucociliary transport
in both physiological and pathological states. The Lego®-like concept
adopted, in this study, enables the development of mucociliary clearance
models with high versatility, since these can be easily modified to
reproduce phenomena characteristic of healthy and diseased human
airways, while allowing to determine the effect of each parameter and/or
structure separately on the overall mucociliary transport. These
Lego®-like airway models can be available off-the-shelf because they are
exclusively made of readily available materials, thus ensuring
reproducibility across different laboratories.
Cardiac lipoblastoma of the pulmonary valve: A rare tumour in an unusual location
Authors: Tong Feng , Guo Zhangke , Bai Song
Published: February 2021

Lipoblastoma is a rare, benign, fatty tissue tumour that occurs in
infancy and early childhood. Intrathoracic and mediastinal involvement
of this tumour is rare, and an intracardiac location is even rarer. In
this study, we report the case of a 15-month-old girl who presented with
a tumour in the pulmonary valve. A complete resection of the tumour was
undertaken, with a histopathology report confirming the diagnosis of
lipoblastoma.
A modeled radiological dispersive device release and the impact to decision-making in an urban environment
Authors: Oliveira Paulo , Oliveira Ubiratan , Stenders Ricardo , Silva Ademir , Vital Helio , Prah Matjaz , Andrade Edson
Published: March 2021

A radiological dispersion device is a weapon that combines radioactive
material with conventional explosives for spreading radioactive material
across an inhabited area. This study is focused on evaluating key
parameters in an radiological dispersion device scenario. The calculations
were performed to include two different situations: by using explosives and
by simple mechanical release. Simulations were conducted with the use of the
HotSpot Health Physics Codes. The results suggest the existence of
significant correlations between stability classes in scenarios where they
evolve with time, producing alternations between them. As long as the
stability class remains constant, this latter finding offers the possibility
of creating a suitable response, based on temporal evolutions. Therefore,
the purpose of this study is to: estimate the size of the potentially
affected population, estimate absorbed doses, and estimate the
cost-effectiveness in order to help initial responses by providing
time-sensitive information about the event. A methodology capable of
providing useful information allows prompt decisions and initial
assessments of future risks to be made efficiently. This approach can also
provide a training environment for the personnel responsible for the
decision-making at an early stage of the response.
Factors Influencing the Quality of Life in Patients with Chronic Kidney Failure Subject To Hemodialysis
Authors: Insfrán José Luis Gamarra , Dias Renato Soares Sanches , Sanches Cristina José Fernandes
Published: February 2021

Introduction: The patient with terminal chronic renal insufficiency in treatment with Dialysis, usually undergoes psychological and social changes, in his lifestyle and also in his spiritual life, which not only affect him, but the whole family of the. For this reason, it is essential to study the quality of life of this type of patient, since it allows us to analyze to what extent a patient's life is affected by the different interventions they require and by the damage caused by the disease and treatment. Objective: To describe the factors that influence the quality of life of patients with chronic renal failure undergoing hemodialysis in nephrology services. Materials and methods: A descriptive, retrospective and cross-sectional study was undertaken. Results: The research allowed determining that in the group of patients under study predominates: the older adult age range, married, presence of family support network, with complete basic education, of urban origin, with more than two pathologies associated with patient and in treatment for a period greater than one year. According to the Areas of the SF-36 health questionnaire, the Functional State Area is perceived as from Fair to Poor (90%); the Welfare Area as Good (70%), the General Health Perception as Good to Fair (92%) and the Health Change over time as Good to Fair (55%). Conclusion: In general, it was concluded that the perception of quality of life is Good. The factors considered to have an influence on this perception are: education, presence of a support network, marital status, origin, associated chronic pathologies and time on hemodialysis.
Strategi Tata Kelola Keamanan di Wilayah Rawan Tindak Kriminalitas Pada Masa Pandemi Covid 19
Authors:   Universitas Lampung, Nasrulloh Dicky Huda , Hutagalung Simon Sumanjoyo ,   Universitas Lampung, Atika Dewie Brima ,   Universitas Lampung
Published: February 2021

Security and orderliness is a basic need that is always expected by the community carrying out their daily activities. Lampung Province is one of the provinces in Indonesia with a fairly high crime rate. Especially in the Bandar Lampung area, the security and public order situation (Kamtibmas) is dominated by the problem of criminal acts of theft with violence and theft of motor vehicles or what is often called Curat, Curas and Curanmor (C3). The Bandar Lampung City Police is one of the state institutions that has the duty and obligation to maintain and at the same time create security and order in the area which is its responsibility. The research method used is descriptive with a qualitative approach, data collection is done by observation, documentation and interviews. The results show that the implementation of the strategy carried out by the Bandar Lampung City Police in realizing security governance has not been maximally achieved because based on the data obtained, the crime rate has increased by 5% in the current Covid-19 pandemic era.
Cytotoxic Potential from the Extracellular Filtrate from Aspergillus niveus Cultured in YPD Medium against Human Tumor Cells
Authors: Alves Thaís Barboni , Roberto Gabriela Molinari , Brassesco Maria Sol , Guimarães Luis Henrique Souza
Published: February 2021

Different fungal species, especially from the genus Aspergillus, have been reported as producers of small molecules, including proteins, with biological activity and a better understanding of their sources, structure, function and toxicity is essential for their biotechnological applications. According to this, our aim was to evaluate the cytotoxic activity of the extracellular filtrate produced by A. niveus. The crude filtrate obtained in YPD medium containing 18 kDa protein, after cultivation for 120 h, was selected for cytotoxic assay, assessed by Giemsa staining, against different human tumor cell lines. Crude filtrate inhibited (from 27% to 50%) the ONS-76 (medulloblastoma), HT144T (melanoma), HOS (osteosarcoma), T98G (glioblastoma) human tumor cell lines and MRC-5 (fibroblasts) human normal cells, at 20 µg/mL for 72 h treatment. According to this, the 18 kDa protein band and the fractions obtained after DEAE-Cellulose procedure were evaluated through mass spectrometry (MS/MS) analysis, revealing the presence of peptides with similarity to the alpha-sarcin, mitogillin and Aspf1 ribotoxins described for other Aspergillus species. In conclusion, the A. niveus extracellular filtrate containing ribotoxin-like proteins reduced, in vitro, the growth of human tumor cell lines indicating their biotechnological potential, indicating a possible future application in the elaboration of immunotoxins.
Plasma-catalytic Efficiency on the Discolouration of Sunset Yellow FCF in a Glidarc Plasma Reactor in Presence of WO₃ Used as Catalyst
Authors: Ndiffo Gervais B. Y. , Djepang Serges A. , Seutcha Romaric L. , Laminsi Samuel
Published: February 2021

In this work, we highlight the plasma-catalytic effect of gliding arc discharge on the bleaching of azo dye sunset yellow FCF in aqueous solution. The effect has been studied in the presence of tungsten oxide as a catalyst in the glidarc reactor. The catalyst has been synthesized via acid precipitation process. The product obtained was  characterized by X-ray powder diffraction (XRD), Fourier Transform Infrared (FTIR) and Nitrogen Physisorption. The results showed firstly monoclinic structure of WO3 catalyst.  The maximum bleaching rates obtained are 17% and 52.5% after 30 min for initial dye concentration of 25 mg.L-1 for plasma alone and plasma-catalyst, respectively. These results have clearly shown that gliding arc discharge has a double effect, in on hand as a source of hydroxyl radical and on other hands as a source of radiation able to excite the catalyst. The effects of initial pH and photocatalyst loading have been studied.
Parameters Affecting the Synthesis of X and A Zeolites from Coal Fly Ash
Authors: Korpa A. , Teneqja V. , Gjyli S. , Andoni A.
Published: February 2021

This paper summarizes the investigation results on the main parameters affecting the synthesis of type X and A zeolites using coal silicious fly ash (FA) as raw material. The synthesis was performed by dissolution of alkali-fused alumino-silicates, followed by hydrothermal treatment. The experimental data confirm that fly ash SiO2/Al2O3 ratio, NaOH/FA ratio, acid treatment of pre-fused fly ash, salinity of solution have a significant effect on type and properties of newly formed zeolites. In summary, the results show that A and X-type zeolite form with FA SiO2/Al2O3 ratio < 1.12 and > 1.86, respectively. Moreover, FA characterized by SiO2/Al2O3 mole ratio of 3.15 is suitable for X-type zeolite synthesis while A-type zeolite does not form without NaAlO2 addition. The crystallization occurs faster at higher temperatures although above 90°C X-type zeolite evolves into more stable phases whereas increasing the crystallization time from 1 to 72 hours, the yield of the synthetic products enhances from 60 to 75%. The use of seawater is responsible for the synthesis of X-type showing both lower purity and specific surface area. However, the synthetic products are characterized by high exchange capacity (> 320 meq/100 g), thus suggesting their successful application as adsorbents and catalysts in different types of wastewater and industrial waste treatments.
Islands with Zero Net Carbon Footprint due to Electricity Use. The Case of Crete, Greece
Authors: Vourdoubas John
Published: February 2021

European islands are pioneers in the development of renewable energy technologies. Aim of the current research is to investigate the possibility of zeroing the net annual carbon emissions due to electricity generation in the island of Crete, Greece. Crete, with population 634,930 permanent residents, has abundant solar and wind energy resources while electricity generation from solar-PV systems and wind farms is highly profitable. The electric grid of Crete was autonomous so far but currently its interconnection with the grid of continental Greece is under construction. This will allow soon the transfer of large amounts of electricity between Crete and the mainland. When excess electricity will be generated by solar and wind energy systems in the island it could be transferred in mainland and vice-versa. Carbon neutrality due to electricity generation in Crete can be achieved with local generation of “green solar and wind electricity” combined with electricity transfer via two electric cables with the mainland. Annual electricity generation in Crete is currently at 3,043 GWh while 21.22% of it is generated by renewable energies. Carbon emissions due to electricity generation are calculated at 3.22 tnCO2/capita. It has been estimated that the required size of solar-PV systems generating annually the electricity currently produced by fossil fuels in Crete is at 1,698 MWp while their cost is at 2.04 bil. €. The required size of wind farms generating annually the electricity currently produced by fossil fuels is at 950.6 MWel while their cost is at 0.914 bil. €. It is concluded that carbon neutrality due to electricity generation in Crete is technically and economically feasible.
Do Companies with Female on the Board have Effects on the Earning Management? Evidence Indonesia Manufacturing Listed Firms
Authors: Trisanti Theresia
Published: February 2021

This study aims to examine the influence of the presence of women on the board such as chief executive officer, chief financial officer and chief audit committee on the earning management (EM) practices and also to examine whether the educational backgrounds of women executive officials have a moderating effect on the earning management practice. The data used is secondary data from Indonesian listed manufacturing companies, hypothesis testing using regression model with partial least square test. Sampling was carried out using a purposive sampling method. The results showed that female chief executive officer and female chief financial officer did not affect earning management practice, but woman as chief audit committee affect the company's earnings management practices. Education background capable as moderating variable to strengthen the influence women as chief executive officer, chief financial officer and women as chief audit committee to earnings management practices. This research can provide contribution for users of financial statements about the possibility of differences in earnings management practices due to the presence of women in top management positions.
سلوكيات القيادة الروحية و دورها في تعزيز الاخلاقيات المهنية
Authors: Ahmed Mohamed E. , Alani Alaa A. , Massoudi Aram H.
Published: March 2021

هدف البحث تحديد مدى التزام الأفراد المبحوثين بأخلاقيات المهنة ، فضلاً عن قياس  طبيعة العلاقة والاثر بين القيادة الروحية بأبعادها الخمسة واخلاقيات المهنة في الميدان المبحوث المتمثل بالمعهد التقني في الموصل، ولتحقيق هذا الهدف تم استطلاع اراء (92) فردًا من التدريسيين العاملين في المنظمة المبحوثة ، ومن خلال توزيع استمارة الاستبيان تم جمع بيانات الجانب العملي ، وقد تبنى البحث عدة فرضيات احصائية ومنها "يوجد علاقة ارتباط معنوية بين القيادة الروحية بأبعادها الخمسة وأخلاقيات المهنة " ولغرض اختبار هذه الفرضية وفرضيات البحث الأخرى تم اعتماد المنهج الوصفي التحليلي في قراءة البيانات ومعالجتها ميدانياً. وانتهى البحث بتقديم جملة من النتائج  كان منها وجود التزام لدى الافراد عينة البحث بأخلاقيات المهنة في المنظمة المبحوثة ، فضلاً عن اثبات فرضيات البحث.
ANALYSIS OF THE EFFECT OF INFLATION, INTEREST RATE, THE MONEY SUPPLY ON RUPIAH EXCHANGE RATE PERIOD 1996-2014
Authors: Siregar Novrida , Nugrahadi Eko Wahyu
Published: February 2021

The data source is from Bank Indonesia (BI), the result of this research shows that the domestic inflation has a significant positive influence to rupiah exchange rate toword American Dollar, and cash rate ratio has a negative influence to Rupiah exchange rate with American Dollar, while overseas inflation, domestic interest rate , overseas interest rate they do not have significant influence toword Rupiah exchange rate with American Dollar. From the determination coefficient result (R2) show that the subject which has been researched can explain 93,11 percent toword Rupiah exchange rate while the rest 3,89 percent can be explained by other subject out of model.