bluuebunny/crossref_metadata_2025 huggingface dataset:
[RETRACTED] [Warning] Prima Weight Loss UK-[10 Facts]-Side Effects 100% Natural "Wieght Loss Pills"Price v1
Authors: Weight Loss UK Prima
Published: July 2022

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[RETRACTED] Total Health ACV Keto Gummies Fat Melting Morning Diet Exposed Or Know Reality About This Formula(Work Or Hoax) v1
Authors: Health ACV Keto Gummies Total
Published: July 2022

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[RETRACTED] Prima Weight Loss Reviews UK [Shark Tank Alert]: Does “Prima Weight Loss“ Work & Price? v1
Authors: not provided maryjsikorski
Published: July 2022

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[RETRACTED] Are There Any Benefits to Using BuzzBGone? v1
Authors: Mcdowell Monee
Published: July 2022

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[RETRACTED] Total Health ACV+Keto Gummies #1 Weight Loss Supplement v1
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[RETRACTED] Prime Choice CBD Gummies (Scam Alert Review) Pain Relief Pill Or Waste Of Money? v1
Authors: not provided pibigi
Published: July 2022

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[RETRACTED] Immunity Advanced Immune Boost Review Natural & Organic Booster UK, US, AU v1
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The importance of applying the statement of assent to children and adolescents: a qualitative study
Authors: Da Silva Varejão Cristiane , Do Espírito Santo Fátima H. , De Souza Ribeiro Maria de Nazaré
Published: July 2022

Objective. To describe the importance of the Statement of Assent for children and adolescents invited to participate in a clinical study and their main reactions to its explanation.

Methods. This is an exploratory descriptive qualitative study of 17 children and adolescents, who were invited to participate in a clinical study in the field of oncology in a hospital located in Rio de Janeiro (Brazil). Data were analyzed using thematic analysis.

Results. Two thematic units were generated after data interpretation: signing the statement of assent, in which participants felt their main role when faced with the possibility of expressing their agreement or not to take part in the study; and understanding of the study, when they showed that they understood the steps of the study by asking pertinent questions to clarify their doubts. Children and adolescents understood the steps of the study contained in the Statement of Assent, were interested and asked questions to clarify their doubts about the study.

Conclusion. The Statement of Assent was important for participants understanding the study and having autonomy over their participation. As the statement strengthened the main role of children and adolescents in the research process, the conclusion was that its use in studies involving the pediatric population should be encouraged.
Proactive Metering of Mobile Internet User Experience
Authors: UZUN Mete , ABUL Osman
Published: July 2022

Having 67% worldwide share, mobile internet is very important for Internet Service Providers (ISPs). Since mobile Internet access is a collective service, Key Performance Indicators (KPIs) measuring quality of data traffic on select network segments/servers may not correctly indicate true user experience. For this reason, mobile ISPs are investing in sophisticated high-end commercial speed analysis systems which typically collect and analyze network traffic data from key network segments/servers. Unfortunately, their utility is quite limited as long as the proactive network intervention is considered. In this work, we develop a MapReduce based network speed analysis system which measures end-to-end network speed to quantify true user experience across multiple geographic regions and service categories. Also functioning as an online decision support system, it enables network administrators with timely ISP network intervention right before potential arrival of mass number of user complaints. The system has been tested with a leading mobile ISP in Turkey. The results confirm its effectiveness.
Development of a Counterfeit Vehicle License Plate Detection System by Using Deep Learning
Authors: AĞGÜL Burak , ERDEMİR Gökhan
Published: July 2022

In this study, a deep learning-based counterfeit plate detection system that compares and detects vehicles with the make, model, color, and license plate is designed. As known that the relevant government institutions are responsible for keeping all detailed information about all motor vehicles in their database. All registration details are stored in the database. It is possible to find unregistered vehicles by comparing database records with detected details. In general, vehicles with counterfeit license plates are used in illegal actions. Therefore, it is of great importance to detect them. Generally, license plate recognition systems successfully detect counterfeit license plates that are randomly generated. Security units typically use such systems at toll roads, bridge crossings, parking lot entrances and exits, sites, customs gates, etc. This kind of system only checks the plate is exists or not in the database. But it is unsuccessful if the vehicle uses existing plate numbers such as stolen ones. In this study, the developed system can detect not only vehicles' plate numbers but also make, model, year, and color information by using deep learning. Thus, the system can also detect randomly generated plates and stolen plates that belong to another vehicle.
Aggression and Autonomy in Adolescence
Authors: Khlomov K.D. , Bochaver A.A. , Fomenko M.S. , Selivanova E.I. , Shemshurin A.A.
Published: July 2022

The paper is devoted to the question of whether there is a connection between aggression and autonomy in adolescence, and whether aggressive behavior can be considered as a tool for solving the age-related problem of developing autonomy. We present results of a study on the relationship between aggressive behavior and the level of autonomy in adolescents aged 13—16 years. At the first stage of the study, the sample consisted of 499 respondents. At the second stage, we compared aggression and autonomy in adolescents with and without school records of aggressive behavior, and the sample consisted of 192 respondents. The research tools included the physical aggression scale from the Buss-Perry Aggression Questionnaire, the Legitimized Aggression Questionnaire by S.N. Enikolopov and N.P. Tsibulsky, the Violent Extremism Dispositions technique by D.G. Davydov and K.D. Khlomov, as well as the Autonomy Questionnaire by N.N. Poskrebysheva and O.A. Karabanova. The results showed significant low negative correlations of autonomy indicators with indicators of physical aggression, legitimized aggression and dispositions of violent extremism, which does not confirm the hypothesis of aggressive behavior as a manifestation of autonomy. A comparison of adolescents with and without school records of aggressive behavior showed significant differences in indicators of physical aggression, legitimized aggression and dispositions of violent extremism (they are higher among those who have no such records), but not in autonomy: thus, an attempt to operationalize aggressive behavior through intra-school records showed an unexpected result, problematizing questions about the normalization of aggressive behavior in the school environment and about the role of school records in the prevention of maladaptive behavior. The results obtained do not confirm positive relationship between adolescent autonomy and aggression. At the same time, the limitations of the study necessitate further studies of this problem, requiring a different operationalization of aggressive behavior and an expansion of the range of variables studied.
Growing Up of Youth: Separation from Parents, Subjective Adulthood and Psychological Well-being at the Age of 18—27
Authors: Manukyan V.R.
Published: July 2022

The article explores the process of growing up in young people in the period of “emerging adulthood” from the perspective of psychological separation from parents and its relationship with the formation of adult identity (subjective adulthood) and psychological well-being. The study was conducted on a sample of 126 subjects aged 18—27 years (M=22.3) with different work and family status. Indicators of psychological separation (Hoffman PSI Questionnaire), psychological well-being (Riff Scale), life satisfaction (Diener scale), happiness level (Fordis scale), indicators of spatial and functional separation, subjective adulthood (survey questions) were measured. The study revealed the heterogeneity of the separation process and the dominance of functional and behavioral aspects over the affective and cognitive ones. Also, the separation from father was more expressed in comparison with the separation from mother. Behavioral components of psychological separation from parents are viewed as predictors of a decrease in satisfaction, happiness, and purposefulness of life. Subjective adulthood is not related to the degree of separation, but it is related to psychological well-being: the highest levels of psychological well-being scales were found in young people with developed adult identity.
Biometric Face Recognition Based on Enhanced Histogram Approach
Authors: Al-Shayea Qeethara Kadhim , Al-Ani Muzhir
Published: July 2022

Biometric face recognition including digital processing and analyzing a subject's facial structure. This system has a certain number of points and measures, including the distances between the main features such as eyes, nose and mouth, angles of features such as the jaw and forehead with the lengths of the different parts of the face. With this information, the implemented algorithm creates a unique model with all the digital data. This model can then be compared with the huge databases of images of the face to identify the subject. The recognition features are retrieved here using histogram equalization technique. A high-resolution result is obtained applying this algorithm under the conditions of a specific image database.
Securing One Time Password (OTP) for Multi-Factor Out-of-Band Authentication through a 128-bit Blowfish Algorithm
Authors: Reyes Ariel Roy L , Festijo Enrique D , Medina Ruji P
Published: July 2022

Authentication and cryptography have been used to address security issues on various online services. However, researchers discovered that even the most commonly used multi-factor out-of-band authentication mechanism was vulnerable to attacks and traditional crypto-algorithms were characterized to have some drawbacks making it crucial to choose desirable algorithms for a particular purpose. This study introduces an innovative modification of the Blowfish algorithm designed to capitalize on its strengths but supports 128-bits block size text input using dynamic selection encryption method and reduction of cipher function execution through randomly determined rounds. Experimentation results on 128-bit input text revealed significant performance improvements with utmost 5.91 % in terms of avalanche effect, 38.97 % for integrity, and 41.02 % in terms of execution time. Results also showed that the modification introduced extra security layer, thus, displaying higher complexity and stronger diffusion at faster execution time making it more difficult and complex for an unauthorized individual to decipher the information and desirable to be used for applications with multiple users respectively. This is a good contribution to the continuous developments in the field of information security particularly in cryptography and towards providing a secure OTP for multifactor out-of-band authentication.
OpenDaylight vs. Floodlight: Comparative Analysis of a Load Balancing Algorithm for Software Defined Networking
Authors: Porras Jonier , Ducuara Daniel , Puerto Gustavo
Published: July 2022

This paper presents the proposal of a load balancing algorithm implemented in two of the most popular controllers for Software Defined Networks (SDN): OpenDaylight and Floodlight. A comparative study in terms of the available bandwidth and delay time of the packet forwarding was performed by means of simulation modeling in a base network in which a shortest path algorithm was implemented as well. The results show that the proposed load balancing algorithm improves significantly the performance of a SDN in terms of the offered QoS of a OpenDaylight based controller. The effect of the proposed load balancing algorithm in the Floodlight controller shows a smaller impact mainly on the bandwidth allocation due to its in-build modules that by default perform specific routing and forwarding operations efficiently according to the traffic demand.
PMSS: Producer Mobility Support Scheme Optimization with RWP Mobility Model in Named Data Networking
Authors: Hussaini Muktar , Nor S. A. , Ahmad A.
Published: July 2022

Abstract: The movement pattern of mobile producer plays an important role in mobility performance analysis of the wireless and mobile network. However, the producer mobility behavior is directly affecting the handoff latency and signaling overhead cost. Many researchers provide analytical investigation to analyze and solve the handoff problems and compared with the simulation result. To justify between simulation and analytical investigation, movement behavior of mobile node needs to be included in the analytical investigation to make it possible to compare with the simulation-based result. This paper incorporated Random WayPoint Mobility (RWPM) model, to determine the behavior of mobile producer, for analytical solution of producer mobility support in NDN. In this paper, we introduce mobility Interest packets to conveyed new prefix or location of mobile producer, a broadcasting strategy to facilitate the handoff process and the immobile anchor router was modified to perform a dual function that is, tagging of anchors and broadcasting of tagged mobility Interest packets. The performance analysis for mobile producer behavior and handoff latency shows that our proposed Producer Mobility Support Scheme (PMSS) reduces handoff latency compared to DNS-like and Home Agent routing approach.
Hygienic approaches to the assessment of occupational morbidity in the Republic of Bashkortostan in the context of the COVID-19 pandemic
Authors: Kazak Anna А. , Shaykhlislamova Elmira R. , Yamaliev Alfred R. , Valeeva Elvira T. , Sandakova Irina V. , Galimova Rasima R. , Suleymanova Irina F.
Published: July 2022

BACKGROUND: In the tense economic and epidemiological conditions that have developed in the country, Rospotrebnadzor bodies and Occupational pathology centers in the Republic of Bashkortostan consider monitoring and analysis of the state of the production environment, indicators of occupational morbidity to be significant areas of their activities.
AIM: To study the state of working conditions and occupational morbidity in the Republic of Bashkortostan during the COVID-19 pandemic.
MATERIAL AND METHODS: The analysis of the main hygienic parameters of harmful factors of the production environment, indicators of occupational morbidity at industrial and agricultural enterprises of the Republic of Bashkortostan for 20202021 was carried out.
RESULTS: According to the data of the Rospotrebnadzor department for the Republic of Bashkortostan, the number of objects with the status of extremely high and high risk at enterprises of the manufacturing, agricultural sectors and the construction industry is significantly higher than the national average. The largest number of registered jobs in the same industries do not meet the hygienic standards in terms of qualitative and quantitative characteristics. The most harmful production factors affecting the formation of the working environment at almost all industrial and agricultural facilities of the republic are factors of the physical nature and the labor process and, as a consequence, the development of occupational diseases in workers. During 20202021, 122 occupational diseases and poisoning cases were registered in the republic. For the first time in the practice of hygienists and occupational pathologists of the republic, the biological factor significantly impacted on the qualitative and quantitative components of occupational morbidity.
CONCLUSION: Against the background of the ongoing pandemic of new coronavirus infection, there is a deterioration in working conditions and occupational health of workers, which requires the development of effective mechanisms that provide for the responsibility of interested government agencies and employers for the attitude to the working environment and the health of workers.
Antiamyloid therapy of Alzheimer’s disease: origins, current state and prospects of development
Authors: Vorobev Sergey V. , Emelin Andrey Yu. , Yanishevskij Stanislav N. , Kostina Elena V. , Galaeva Anna A.
Published: July 2022

Over the past historical period, views on Alzheimers disease therapy have undergone significant changes. This was facilitated by new research in the framework of studying the mechanisms of its development. Currently, the amyloid hypothesis remains prevalent, the central link of which is the accumulation of insoluble beta-amyloid protein, which provokes a subsequent cascade of pathochemical reactions leading to the formation of dementia. The presence of reliable evidence of a significant contribution of -amyloid in the processes of neurodegeneration contributed to the development of therapeutic strategies aimed at leveling its pathological influence. In this regard, attempts are being made to develop antibodies to -amyloid, to create -secretase and -secretase inhibitors, -secretase stimulants, as well as the synthesis of drugs capable of blocking zinc- and copper-induced formation of toxic forms of oligomers and aggregation of -amyloid. The greatest success was achieved with the introduction of monoclonal antibodies to the protein -amyloid. It is in this direction that the greatest efforts of scientists are focused on creating a new effective treatment for Alzheimers disease.
Detection and Characterization of Microseismic Events from Fiber-Optic DAS Data Using Deep Learning
Authors: Huot Fantine , Lellouch Ariel , Given Paige , Luo Bin , Clapp Robert G. , Nemeth Tamas , Nihei Kurt T. , Biondi Biondo L.
Published: July 2022

Microseismic analysis is a valuable tool for fracture characterization in the Earth’s subsurface. Distributed acoustic sensing (DAS) fibers are deployed at depth inside wells, so they hold vast potential for high-resolution microseismic analysis. However, the accurate detection of microseismic signals in continuous DAS data is challenging and time consuming. We designed, trained, and deployed a deep learning model to detect microseismic events in DAS data automatically. We created a curated dataset of nearly 7000 manually selected events and an equal number of background noise examples. We optimized the deep learning model’s network architecture together with its training hyperparameters by Bayesian optimization. The trained model achieved an accuracy of 98.6% on our benchmark dataset and even detected low-amplitude events missed during manual labeling. Our methodology detected more than 100,000 events, allowing for a far more accurate and efficient reconstruction of spatiotemporal fracture development than would have been feasible by traditional methods.
CubeNet: Array-Based Seismic Phase Picking with Deep Learning
Authors: Chen Guoyi , Li Junlun
Published: July 2022

In recent years, a variety of deep learning (DL) models for seismic phase picking have attracted considerable attention and are widely adopted in many earthquake monitoring projects. However, most current DL models pick P and S arrivals trace by trace without simultaneously considering the spatial coherence of seismic phases among different stations in a seismic array. In this study, we develop a generalized neural network named CubeNet based on 3D U-Net to properly consider the spatial correlation of individual picks at different stations and thus improve the picking accuracy. To deal with data acquired by irregularly distributed stations, seismic data are first regularized into data cubes, which are then fed into CubeNet to calculate probability distributions of P arrivals, S arrivals, and noise. In addition, a variable trace resampling method for optimizing the differential sampling points between P and S arrivals in a trace for varying array apertures is also proposed to further improve the picking accuracy. CubeNet is trained by 47,000 microseismic data cubes and then tested by three data sets from different arrays with varying apertures and station intervals. It is found that CubeNet is rather resilient to impulsive noise and can avoid misidentifying most of the abnormal picks, which are challenging for the signal-trace based phase picking methods such as PhaseNet. We believe the newly proposed CubeNet is especially suitable for processing seismic data collected by large-N arrays.
Novel Therapies in BCMA-exposed Relapsed/Refractory Multiple Myeloma: The Anti-BCMA Therapy-refractory Patient
Authors: Golden Emma ,   Sarah Cannon Research Institute at the Colorado Blood Cancer Institute, Denver, CO, USA, Ingram Sara ,   Sarah Cannon Research Institute at the Colorado Blood Cancer Institute, Denver, CO, USA, Schade Henning ,   Sarah Cannon Research Institute at the Colorado Blood Cancer Institute, Denver, CO, USA, Matous Jeffrey ,   Sarah Cannon Research Institute at the Colorado Blood Cancer Institute, Denver, CO, USA, Gregory Tara K ,   Sarah Cannon Research Institute at the Colorado Blood Cancer Institute, Denver, CO, USA
Published: July 2022

Multiple myeloma (MM) is a haematologic malignancy resulting from the malignant overgrowth of monoclonal plasma cells in the bone marrow. Nearly 35,000 new cases are expected in the USA each year. In the last two decades there have been many clinical advances with the approvals of many new drugs and their combinations, which have improved survival statistics. Despite this, MM remains incurable, and patients with relapsed/refractory MM remain vulnerable. The development of chimeric antigen receptor T-cell (CAR-T) therapy has shown promising results utilizing several target antigens; of note, B-cell maturation antigen (BCMA) is most prominent, due to its universal expression on the surface of malignant plasma cells. While anti-BCMA CAR-T therapies are inspiring, most patients eventually relapse and require further treatment. With these patients progressing through standard-of-care therapies, and more recently through novel anti-BCMA CAR-T therapies, we are faced with exploring novel treatment regimens to challenge their diseases. In this review, we discuss the different mechanisms of resistance to anti-BCMA therapies, effective retreatment with anti-BCMA-targeted therapies in MM, and advances in therapies utilizing other novel targets for patients who have progressed through anti-BCMA treatment.
COVID Coagulopathy and Thrombosis: A Systematic Review
Authors: Asrani Roshan ,   Department of Medicine/Hematology, Stony Brook University, Stony Brook, NY, USA, Bahou Wadie F ,   Department of Medicine/Hematology, Stony Brook University, Stony Brook, NY, USA
Published: July 2022

Introduction: Since the onset of the SARS-CoV-2 pandemic, haematological laboratory abnormalities and thrombotic complications have been observed among infected patients. We aimed to highlight key pathophysiological mechanisms of COVID-19-associated coagulopathy and to summarize incidence rates of venous and arterial thrombotic events, comorbidities conferring risk, and current treatment guidelines including data from ongoing clinical trials. Methods: A systematic review was performed according to PRISMA recommendations of case–control studies, cohort studies, observational studies and randomized clinical trials (RCTs) published between 1 December 2019 and 30 September 2021 within PubMed and Web of Science. Inclusion criteria were English language, adult patients and at least one coagulation parameter described. Results: 2,554 records were screened, from which 59 studies were included. Abnormalities in several laboratory parameters were associated with worse clinical outcomes including elevations in prothrombin time, activated partial thromboplastin time, D-dimer, fibrinogen, von Willebrand factor antigen/activity and lupus anticoagulant antibodies. Rates of venous and arterial thromboembolism varied significantly among studies performed early in the pandemic and across different nations. Pathophysiological mechanisms included vascular endotheliopathy, increased inflammation and macrophage activation, neutrophil extracellular traps, antiphospholipid antibody production and obesity/adipose tissue signalling. Current recommendations for management of COVID coagulopathy from various societies include the use and dosing of systemic anticoagulation to prevent thrombotic sequelae in the outpatient, inpatient and critical care settings. The optimal anticoagulant dose for thromboprophylaxis in the inpatient and critical care settings is currently not well established. Conclusions: SARS-CoV-2 infection can cause a distinct form of coagulopathy, with thromboembolic complications leading to significant morbidity and mortality. The optimal treatment requires further refinement pending the results from key ongoing RCTs
The Role of Self-management in Inflammatory Arthritis
Authors: Nikiphorou Elena ,   King's College London, London, UK
Published: July 2022

Self-management in inflammatory arthritis (IA) is a multi-component and complex intervention, presenting an unmet need in the care of people with IA. The ability to self-manage in IA is an essential component of care that goes beyond drug therapy and allows the patient to work on managing the practical, physical and psychological impacts of disease. Self management is useful to support an individual to achieve and maintain independence. Healthcare professionals should be given adequate guidance and professional training to support patients in self-management of their disease. Recently, the European Alliance of Associations for Rheumatology (EULAR) produced guidelines for the implementation of self-management strategies in patients with inflammatory arthritis,1 this editorial discusses the key recommendations in the guidelines.
Experience with stereotactic r adiation therapy for liver oligometastases of colorectal cancer
Authors: Moskalenko A. N. , Chernykh M. V. , Sagaidak I. V. , Ishchanov D. G. , Garipov M. R. , Lyadov V. K.
Published: July 2022

Introduction: The problem of treating patients with unresectable liver metastases of colon cancer is currently far f rom being solved. One possible approach is the use of stereotactic body radiotherapy.

The purpose of this study was to evaluate the immediate and long-term results of stereotactic radiotherapy in patients with colorectal cancer and oligometastatic liver metastases.

Methods: This study was designed as a retro-prospective, open-label, controlled, non-randomized clinical trial. We assessed one-year local control, one-year overall survival, progression-free survival, and toxicity in 60 patients with oligometastatic liver disease from colorectal cancer who underwent stereotactic body radiotherapy, with median dose of 54 Gy.

Results: The median follow-up was 20,1 months. One-year local control (LC) was 73,7 % (95 % CI = 62,7–86,6 %). Oneyear overall survival (OS) was 92,8 % (95 % CI = 86,3–99,9 %), one-year progression-free survival (PFS) was 31,3 % (95 % CI = 21,1–46,4 %) with a median of 8,1 months. Grade ≥ 3 toxicity was not noted. No cases of radiation-induced liver failure were observed. Radiation dose (HR = 0.88, 95 % CI = 0.81–0.95, p = 0.00087), metastasis size (HR = 1.51, 95 % CI = 1.07–2.12, p = 0.01858) and their number (HR = 1.8, 95 % CI = 1.01–3.22, p = 0.04669) are significant risk factors for LC. Metastasis size > 3 cm is a significant risk factor for LC (HR = 5.5, 95 % CI = 1.7–17.9, p = 0.005) and OS (HR = 3.8, 95 % CI = 1.3–11.7, p = 0.02).

Conclusion: Stereotactic body radiotherapy is an effective and safe method of providing local control of oligometastatic liver metastases in colorectal cancer as part of a combined treatment approach. Further studies are required to individualize the indications for this treatment method.
Case report: treatment of metastatic renal cell carcinoma with nivolumab plus cabozantinib in routine clinical practice
Authors: Menshikov K. V. , Sultanbaev A. V. , Izmailov A. A. , Musin Sh. I. , Menshikova I. A. , Chalov V. S. , Sultanbaeva N. I. , Lipatov D. O.
Published: July 2022

According to GLOBOCAN, there were about 18 million new cases of cancer and 9.6 million deaths from malignancies worldwide in 2018. Renal cell carcinoma is a malignant tumor characterized by the loss of the VHL gene, which leads to increased angiogenesis. The potential of immuno-oncology and anti-angiogenic drugs has significantly improved outcomes for patients with metastatic renal cell carcinoma. The phase III CheckMate 9ER study compared the efficacy and safety of nivolumab plus cabozantinib versus sunitinib in the first-line treatment of patients with metastatic clear cell renal cell carcinoma. The advantages of nivolumab plus cabozantinib over sunitinib in terms of progression-free survival, overall survival, and objective response rate were generally similar across subgroups based on IMDC risk, PD-L1 expression, and the presence or absence of bone metastases. We present a case report of metastatic renal cell carcinoma. The patient has been on cabozantinib plus nivolumab therapy for 12 months, with a partial response achieved. Treatment was well tolerated; the profile of adverse events was consistent with that in the clinical study.
Refrigerant progression - an investigation into eco-sustainability with evolution and viability of fourth generation refrigerants
Authors: KHATOON Salma , NAWAB KARIMI Munawar
Published: July 2022

Global warming is one of the most pressing issues the world is facing today. The refrigeration sector, one of the major contributors to global warming, needs to follow a methodological approach to address this issue. This paper evaluates the overall warming impact along with the thermodynamic performance of the different generations of refrigerants in the cascade refrigeration system. The main aim of this comparative study is to present a comprehensive outlook on the environmental impact of refrigerants. A different perspective on refrigerant selection to reduce global warming is also discussed. R600a, R290, R12, R22, R134a, R152a, R245fa, R1234yf, and R1234ze are used in the high-temperature circuit, while R32 is used in the low-temperature circuit. Exergy and energy analyses are done for thermodynamic performance, and total equivalent warming impact (TEWI) assessment is carried out to show global warming produced. While the refrigerant couple R152a/R32 shows the best thermodynamic performance with maximum COP, minimum exergy destruction, and maximum second law efficiency, R1234yf/R32 displays the worst thermodynamic performance. R12/R32 shows maximum TEWI while R290/R32 shows minimum TEWI. The first-generation refrigerants are found to be most environmentally friendly followed by the third and fourth. Fourth-generation refrigerants have the highest indirect emissions, which make their TEWI comparable to R134a. It is concluded that thermodynamic performance plays a significant role in reducing TEWI as indirect emissions account for the major part of the TEWI, and therefore, the global warming potential cannot be the only basis for refrigerant selection. This study suggests that first-generation refrigerants and R152a can be better alternatives.
The Effect of Sunnah Fasting on Blood Pressure and Oral Hygiene Level
Authors: Mahanani Erlina Sih , Hapsari Hana Aulia , Ahyati Dinda Triani
Published: July 2022

The Monday-Thursday fasting, as one of the sunnah highly recommended by Rasulullah, can be a key to maintaining health. This research aims to determine the difference in blood pressure and oral health among the santriwati in Madrasah Mu’allimat Muhammadiyah Yogyakarta who have gotten used to doing and those who have not gotten used to doing Monday-Thursday fasting. It is an observational quantitative research using a cross-sectional design. They were 48 santriwati of 14-18 years old as subjects. Blood pressure was measured thrice with a minimum measurement interval of 15 minutes. The dental and oral hygiene level was obtained using the OHI-S measurement index. The students who habitually carried out sunnah fasting had a normal blood pressure of 20.8% (of a total of 27.1%), and all students had a good level of OHI (27.1%). Meanwhile, among students who are not accustomed to fasting, 45.8% had abnormal blood pressure (a total of 72.9%), and the good level of OHI was only 47.9%. The analysis of Mann-Whitney data showed a significant value for the blood pressure category variable of 0.015 and the OHI-S category of 0.015. The significance level of p 0.05 for each measurement variable (blood pressure and OHI-S categories) illustrated that there were differences in blood pressure and oral hygiene among the santriwati who had gotten used to doing and those who had not gotten used to doing Monday-Thursday fasting.
A review on role of autopsy in the diagnosis of sudden arrhythmic deaths
Authors: Mada Prashanth , Parmar Pragnesh , S Yadukul , Pannala Divya Reddy
Published: July 2022

Sudden death (SD) is described as “death within 24 hours from the earliest manifestation, without any proof of violence and with no pre-existing disease, where no cause of death can be identified clinically”. In about 5%–10% of cases of sudden cardiac death (SCD), no underlying heart disease can be found at autopsy. Mostly these are the arrhythmic SCD and have a morphologically normal heart. There is a scope for uncertainty among relatives and/or investigating authorities regarding the cause & manner of death specifically in unattended sudden cardiac death. The postmortem examination must include detailed history or clinically relevant information of the deceased, his/her family members, macroscopic, microscopic, toxicological & molecular examination.
An autopsy study of fatal electrocution
Authors: Rao Dinesh
Published: July 2022

Electrical Fatality is not Uncommon in Low voltage and High voltage despite rapid advances in its Transmission and usage. It is essential to understand the Injuries and the manner of Death in all Electric Fatalities.

To Understand the Manner of Death, Pattern of injuries, Site of Injuries and Cause of Death in Fatal Electrocution.

All the cases Electrical Fatalities Referred by the Police for Autopsies were Analyzed & Examined.

Electric Fatalities Contributed to 4% of the Autopsies. Major Age Group Affected was 21-40 years in 75% of cases. Males to Females Ratio 14.5:1. Accidental Deaths were the Major Number of Fatalities in 96.8% of cases. Low Voltage Electrical Current contributed to 79% of Fatalities. Right Hand was involved in contact injury in 51.7% of Deaths and in 9.7% of Fatal Electrocution No Contact or Exit Injuries were Present.
Bomb explosions fatalities in civilian area: Two unusual cases
Authors: Varu Pratik R. , Trangadia Mahesh M , Kyada Hetal C. , Dhruv Sarthak Hitesh
Published: July 2022

While bomb blasts are often associated with wars and terrorism in military and terrorism-prone areas, these events are incredibly rare in other civilian areas. Consequently, forensic medicine experts are rarely exposed to such cases. Explosion injuries produce a distinctive pattern on the body that can help determine the cause of death and reconstruct the crime scene. As such, it is imperative for an autopsy surgeon to be aware of the pattern of bomb blast injuries as well as their mechanisms. In this article, we present autopsy findings of two scrape yard workers who were killed by a bomb blast while breaking scrapes that they received from an army firing range. Furthermore, we have tried to correlate autopsy findings with the circumstances of the blast.
DETERMINING THE STATUS OF THE ONTOLOGY OF THE DAKWAH STRATEGY
Authors: Setiawan Ariadi Yury , Maulida Siti Zumrotul
Published: July 2022

Determining the ontology status of a science becomes important. Especially if the science is used as a study or theoretical basis to explore the object of research. Da'wah strategy as a science at this time is needed by a religious institution or preacher to spread religion. For this reason, the spread of various religions in Indonesia requires a different strategy from each religion. Writing this article aims to determine the ontology status of the da'wah strategy carried out by the Malang Prayer Center Foundation (YSC) and as a pre-research activity prior to field research. The success of YSC's da'wah strategy in Tugurejo Village is an interesting research object to know so that it can be used as a da'wah strategy for other religious groups, especially those motivated by religious conversion. Spreading religion (preaching) to fellow believers is indeed necessary to achieve the degree of piety. However, there will be conflicts between religious communities if the da'wah is intended for religious conversion. For this reason, an appropriate da'wah strategy is needed in accordance with the nature of its ontology as a science. The research in writing this article is based on a type of qualitative research literature study which has seven steps in the research process. From this literary research, it can be concluded that at this time there are various da'wah strategies, including smart da'wah, wasahtiyah da'wah, al Bayanuni da'wah. Based on the three da'wah strategies, the ontology of YSC Malang's da'wah strategy leads to wasahtiyah da'wah.
Distribution of Fee between Blockchain Nodes and the Rule of their Motivation
Authors: Bardin A.P. , Novitsky A.V. , Shumilov Yu.Yu.
Published: July 2022

The article сconsiders the proposed approach for assessing the possibility of equitable receipt of fees by blockchain nodes for closing blocks. The theory of random processes is applied to describe transaction flows and block closings. The distribution of fees received by the nodes for closing a block is analyzed. The fees are the values of a normally distributed random variable and they differ slightly in value. The concept of a master node and an empty block is specified. An estimate of the probability of fee receiving by blockchain nodes for closing a block which are close to the average value is proposed based on the law of large numbers. The variant of the operation of the blockchain network, in which some of the nodes are disconnected from the network, is considered. In this case, the distribution of fees between the nodes is changed, but the equality of the nodes can still be preserved if the proposed additional conditions are met. A rule is formulated for motivating nodes to maintain their constant connection to the network by transferring fees intended for nodes that did not respond to the request to become a master node and summing them with the fee for the first node that responded to the request. Special penalty functions regulating the amount of the fee are applied, which makes it possible to maintain the equality of nodes in this case as well. The more general case allowing temporary shutdown of a part of the nodes of the blockchain network is considered. The analysis of the situation when the nodes are forced to shut down for technical reasons is performed
Improving the Organization of Metrological Support Based on Methods of Operation Research
Authors: Bejseev S.A. , Naukenova A.S. , Korsun O.N. , Ivakhnyuk G.K. , Tulekbaeva A.K. , Goro S.
Published: July 2022

The article considers the problem of improving the methods of organizing the metrological support of enterprises based on the methods of operation research as well as the problem of optimizing the traveling routes of metrological groups mathematically reduced to the classical traveling salesman problem. A brief overview of the methods used in this task is presented, and the relationships between them are shown. Solving the problems based on contemporary geographic information systems and standard software modules from the Python application libraries are proposed. Much attention is paid to simple methods for checking the correctness of the results obtained by standard methods, used by metrological service employees not specialized in the field of programming and geographic information systems, which increases the likelihood of errors. To identify errors occurring when working with geoinformation systems, allowing the matrix of distances between points to be determined, a simple formula borrowed from topography is proposed for calculating the distances between points with known coordinates. With a developed road network, the distances calculated in this way are close to the results obtained in geoinformation systems taking into account the location of highways. The results of solving the problem are given on the example of the organization of verification and repair of measuring instruments at food industry enterprises in the city of Chimkent and he Turkestan region of the Republic of Kazakhstan
Spiritual Farming: A Tool for a Sustainable Agriculture Revolution: A Review
Authors: Ajaykumar R. , Balamurali B. , Sivasabari K. , Vigneshwaran R.
Published: July 2022

Agriculture is extremely important in a developing country like India. Apart from fulfilling the food requirement of the growing Indian population, it also helps to improve the country’s economy. By 2050, 60% of India’s population would have severe food insecurity. Increased food production is critically needed, but high production costs and market price fluctuations are forcing farmers into debt. The usage of chemical fertilizers and pesticides has expanded in India since the green revolution. Excessive chemical use has a negative influence on the ecosystem, soil, human health and groundwater purity. Spiritual farming or Zero Budget Natural Farming (ZBNF) is the most effective way to lower farmers’ input costs. Subhash Palekar practised and advocated Zero Budget Natural Farming (ZBNF) in India. Building elements of ZBNF are jeevamrith, bijamrith, mulching and soil aeration. These four approaches contribute to improved soil health, microbial population and crop output. Intercropping, contour bunds, crop rotation, green manures, compost, and biological pest management is some of the other fundamental elements. Spiritual farming as the potential to reduce pollution while also preserving productivity in our agroecosystem and has the ability to improve agricultural viability and food security.
Detection of Multiple Hepatic Peribiliary Cysts in Captive Lions (Panthera leo)
Authors: Manjunatha V. , Rout M. , Jaisingh N. , Shankar B.P. , Umashankar K.S.
Published: July 2022

Background: Hepatic lesions in non-domestic felids are poorly characterized. The present study reports multiple hepatic peribiliary cysts in 9 out of 32 lions (Panthera leo) at Bannerghatta Biological Park, Bengaluru. Methods: The animals were presented for necropsy after the history of clinical signs of lethargy, anorexia, weakness, debilitated body conditions and all animals are in old age (between 15 to 25 years old). Systematic necropsy with gross and histopathological examination was carried out. Result: Post-mortem examination grossly revealed multiple cysts in liver (varying in each case) with the cystic masses filled with clear fluid, sometimes mixed with bile. A diagnosis for the presence of spontaneous peribiliary cysts was made on the basis of gross and microscopic lesions. Histologically, the cysts were surrounded and composed of compact collagenous tissue. The inner cystic single layer resembled biliary mucosa and composed of columnar epithelial lining, while the submucosa was composed of connective tissue with loss of hepatic cord structure.
Pathology of PMWS Associated with Classical Swine Fever Virus, Porcine Parvo Virus and Multidrug Resistant Enteric Escherichia coli Infections in an Organized Swine Farm, Rajasthan, India
Authors: Das T. , Sethi M. , John J.K. , Tomar N. , Chavan A.S. , Pathak M. , Saikumar G.
Published: July 2022

Background: Postweaning multisystemic wasting syndrome (PMWS) is caused by porcine circovirus type 2 (PCV2). It is a globally emerging clinical condition which affects nursing piglets and growing pigs. PCV2 requires various cofactors for fully development of PMWS. The present report describes the pathology of PMWS associated with classical swine fever virus (CSFV), porcine parvo virus (PPV) and multidrug resistant enteric Escherichia coli infections in an organized swine farm, Rajasthan. In India, this is the first report on pathology of PMWS associated with all the three viruses and multidrug resistant enteric colibacillosis. Methods: Detailed necropsy was conducted on pig carcass submitted to Post-mortem Facility, Division of Pathology, ICAR-Indian Veterinary Research Institute (IVRI), Izatnagar in the year 2017 from an organized swine farm, Rajasthan, India. Heart blood and diarrhoeic intestinal contents were collected aseptically and stored separately at 4°C for bacteriological examination and antibiotic sensitivity test. Tissue samples were collected in sterile container and stored at -40°C for DNA and RNA extraction and polymerase chain reaction (PCR) and also collected in 10% neutral buffered saline for histopathological processing. Result: The organized farm was having history of 33% (200/600) of mortality among 2 months to 6 months old piglets. Gross lesions were wasting, lymphadenopathy, non-collapsed lungs, hydropericardium, hepatomegaly, icterus, enteritis and pale kidneys, button shaped ulcers in the caecum and colon etc. Histopathologically, lymphoid depletion, reticuloendothelial cell proliferation in lymphoid tissue, fibrin thrombi in spleen, severe hepatitis, interstitial pneumonia, interstitial nephritis, severe necrosis in large intestine, meningitis, perivascular cuffing (PVC), gliosis, neuronal degeneration in cerebrum etc were observed. Molecular diagnosis and bacteriological examination confirmed presence of PCV2, PPV, CSFV and multidrug resistant Escherichia coli.