bluuebunny/crossref_metadata_2025 huggingface dataset:
INSPECT-SPSW: INelastic Seismic Performance Evaluation Computational Tool for Steel Plate Shear Wall Modeling in OpenSees
Authors: AlHamaydeh Mohammad , Maky Ahmed Mansour , Elkafrawy Mohamed
Published: April 2023

Modeling Steel Plate Shear Wall (SPSW) behavior can be computationally demanding. This is especially true when high-fidelity modeling is carried out via shell or 3D solid elements. It has been shown that SPSW behavior can be captured with adequate accuracy through the strip method via nonlinear truss elements idealization. The widely accepted and reliable analysis platform, OpenSees, requires text-based input (.tcl) files created by a skilled programmer. Hence, a Pre/Post-processing User Interface (UI) software package (INSPECT-SPSW) is introduced herein. With basic input, the INSPECT-SPSW package allows the user to create the OpenSees (.tcl) input file, run different nonlinear analyses, and retrieve and visualize the output. In addition, the UI includes illustrated wrappers for several OpenSees commands for various material definitions, plasticity modeling options, modal analysis, and nonlinear analysis types. Validation and verification were conducted against published results of experimental and numerical cyclic loading specimens. The user-friendly interface successfully created accurate models that capture the SPSW nonlinear behavior, including the various possible failure mechanisms. e.g., beam or column plastic hinging, web plate yielding, etc. With demonstrated performance and intuitive UI, INSPECT-SPSW is expected to facilitate the broad adoption of the strip method for Performance-Based Earthquake Design (PBED) of SPSWs.
Review of the Numerical Simulation of the Wind and Pollutant Diffusion in Urban Street Canyon under the Influence of Trees
Authors: Wang Le , Tian Wenxin , Zheng Peilin
Published: April 2023

Tree is an essential factor affecting airflow and pollutant diffusion in the urban street canyon. The wind environment in the urban street canyon will be effectively improved by expounding the mechanism and implementing greening measures. Moreover, it will help decrease the pollutant concentration around the street canyon. This paper reviews the airflow and pollutant diffusion numerical simulation in the street canyon under the tree influence. Firstly, the numerical mathematical model used for pollutant diffusion and airflow in urban street canyons under the influence of trees is summarized. The representation of trees’ numerical mathematical model in the simulation domain is mainly proposed. Secondly, the wind environment and pollutant distribution factors influencing urban street canyons are elaborated and analyzed, including tree characteristics, layout, street canyon shape, and thermal. Furthermore, current research progress and deficiencies are discussed. Finally, the future research direction of wind environment and pollutant distribution simulation in urban streets under the influence of trees is pointed out.
Cyclooxygenase and Lipoxygenase Gene Expression in the Inflammogenesis of Colorectal Cancer: Correlated Expression of EGFR, JAK STAT and Src Genes, and a Natural Antisense Transcript, RP11-C67.2.2
Authors: Kennedy Brian M. , Harris Randall E.
Published: April 2023

We examined the expression of major inflammatory genes, cyclooxygenase-1, 2 (COX1, COX2), arachidonate-5-lipoxygenase (ALOX5), and arachidonate-5-lipoxygenase activating protein (ALOX5AP) among 469 tumor specimens of colorectal cancer in The Cancer Genome Atlas (TCGA). Among 411 specimens without mutations in mismatch repair (MMR) genes, the mean expression of each of the inflammatory genes ranked above the 80th percentile, and the overall mean cyclooxygenase expression (COX1+COX2) ranked in the upper 99th percentile of all genes. Similar levels were observed for 58 cases with MMR mutations. Pearson correlation coefficients exceeding r = 0.70 were observed between COX and LOX mRNA levels with genes of major cell-signaling pathways involved in tumorigenesis (Src, JAK STAT, MAPK, PI3K). We observed a novel association (r = 0.78) between ALOX5 expression and a natural antisense transcript (NAT), RP11-67C2.2, a long non-coding mRNA gene, 462 base pairs in length that is located within the terminal intron of the ALOX5 gene on chromosome 10q11.21. Tumor-promoting genes highly correlated with the expression of COX1, COX2, ALOX5 and ALOX5AP are known to increase mitogenesis, mutagenesis, angiogenesis, cell survival, immunosuppression and metastasis in the inflammogenesis of colorectal cancer. These genes and the novel NAT, RP1167C2.2 are potential molecular targets for chemoprevention and therapy of colorectal cancer.
Immobilized KDN Lipase on Macroporous Resin for Isopropyl Myristate Synthesis
Authors: Song Ming , Xin Yuhan , Cai Sulan , Xu Weizhuo , Xu Wei
Published: April 2023

Free enzymes often face economic problems because of their non-repeatability and variability, which limit their application in industrial production. In this study, KDN lipase was immobilized with the macroporous resin LXTE-1000 and glutaraldehyde. The optimal conditions of enzyme immobilization were defined by a single factor experiment and response surface methodology (RSM). The concentration of the cross-linking agent glutaraldehyde was 0.46% (v/v), the cross-linking temperature was 25.0 °C, and the cross-linking time was 157 min. The enzyme activity of the immobilized KDN lipase after adsorption/cross-linking was 291.36 U/g, and the recovery of the enzyme activity was 9.90%. The optimal conditions for the synthesis of isopropyl myristate were catalyzed by the immobilized KDN lipase in a solvent-free system: immobilized enzyme 53 mg, reaction temperature 36.1 °C, myristic acid 228.4 mg, isopropanol 114 µL, and reaction time 18 h. The yield of isopropyl myristate was 66.62%. After ten cycles, the activity of the immobilized KDN lipase preserved more than 46.87% of its initial enzyme activity, and it demonstrated high tolerance to solvents compared to free KDN lipase.
Reversing Dysdynamism to Interrupt Mitochondrial Degeneration in Amyotrophic Lateral Sclerosis
Authors: Dorn Gerald W.
Published: April 2023

Amyotrophic lateral sclerosis is one of several chronic neurodegenerative conditions in which mitochondrial abnormalities are posited to contribute to disease progression. Therapeutic options targeting mitochondria include enhancing metabolism, suppressing reactive oxygen production and disrupting mitochondria-mediated programmed cell death pathways. Herein is reviewed mechanistic evidence supporting a meaningful pathophysiological role for the constellation of abnormal mitochondrial fusion, fission and transport, collectively designated mitochondrial dysdynamism, in ALS. Following this is a discussion on preclinical studies in ALS mice that seemingly validate the idea that normalizing mitochondrial dynamism can delay ALS by interrupting a vicious cycle of mitochondrial degeneration, leading to neuronal die-back and death. Finally, the relative benefits of suppressing mitochondrial fusion vs. enhancing mitochondrial fusion in ALS are speculated upon, and the paper concludes with the prediction that the two approaches could be additive or synergistic, although a side-by-side comparative trial may be challenging to perform.
High-Fat Diet Modulates the Excitability of Neurons within the Brain–Liver Pathway
Authors: Molinas Adrien J. R. , Desmoulins Lucie D. , Davis Roslyn K. , Gao Hong , Satou Ryousuke , Derbenev Andrei V. , Zsombok Andrea
Published: April 2023

Stimulation of hepatic sympathetic nerves increases glucose production and glycogenolysis. Activity of pre-sympathetic neurons in the paraventricular nucleus (PVN) of the hypothalamus and in the ventrolateral and ventromedial medulla (VLM/VMM) largely influence the sympathetic output. Increased activity of the sympathetic nervous system (SNS) plays a role in the development and progression of metabolic diseases; however, despite the importance of the central circuits, the excitability of pre-sympathetic liver-related neurons remains to be determined. Here, we tested the hypothesis that the activity of liver-related neurons in the PVN and VLM/VMM is altered in diet-induced obese mice, as well as their response to insulin. Patch-clamp recordings were conducted from liver-related PVN neurons, VLM-projecting PVN neurons, and pre-sympathetic liver-related neurons in the ventral brainstem. Our data demonstrate that the excitability of liver-related PVN neurons increased in high-fat diet (HFD)-fed mice compared to mice fed with control diet. Insulin receptor expression was detected in a population of liver-related neurons, and insulin suppressed the firing activity of liver-related PVN and pre-sympathetic VLM/VMM neurons in HFD mice; however, it did not affect VLM-projecting liver-related PVN neurons. These findings further suggest that HFD alters the excitability of pre-autonomic neurons as well as their response to insulin.
A Medical Equipment Lifecycle Framework to Improve Healthcare Policy and Sustainability
Authors: Mang Bruce , Oh YeonJae , Bonilla Chabelly , Orth Jennifer
Published: April 2023

The healthcare sector is struggling to become more environmentally friendly compared to other industries, evidently seen by the contribution to global emissions. These struggles have elicited some research on sustainable methods regarding the lifecycle of medical devices. Indeed, the World Health Organization (WHO) encourages the reuse of equipment and ethical donations, namely for the sake of the environment and sustainable global health. However, there is a lack of synthesis–multiple greener alternatives to the current healthcare system are developing without a connection to each other, hindering an increase in sustainability. Thus, there is a lack of global organization and standardization in medical equipment lifecycles. Inspired by the findings and guidelines of the Safe and Sustainable Medical Equipment Supply Subgroup (SASMES) of the International Rotary Fellowship of Healthcare Professionals, we created the Re-processing Medical Equipment: Rotarian Research Group for the Environment (Re-MERGE) to expand on these challenges. Re-MERGE follows the life cycle of medical devices in the United States of America through its initial stages of classification and various regulatory pathways, the middle stage of post-market requirements, and the end stage of disposal or donation and reprocessing. Our findings indicate that current medical device end-stages are inefficient, damaging to the environment, and burdensome to donation recipients; however, existing processes can provide improvements to medical device end-stage methods by drastically reducing environmental damage, improving healthcare globally, and increasing sustainability in the field. We identify that more research is needed to connect the implications of different medical device end stages. Additionally, we encourage the findings to be implemented to create more sustainable, effective methods of medical device disposal, donation, and reprocessing.
LFA: The Mysterious Paper-Based Biosensor: A Futuristic Overview
Authors: Singh Saumitra , Hasan Mohd. Rahil , Jain Akshay , Pilloton Roberto , Narang Jagriti
Published: April 2023

Lateral flow assay (LFA) is emerging as one of the most popular paper-based biosensors in the field of the diagnostic industry. LFA fills all the gaps between diagnosis and treatment as it provides beneficial qualities to users such as quick response, Point-of-care appeal, early detection, low cost, and effective and sensitive detections of various infectious diseases. These benefits increase LFA’s dependability for disease management because rapid and accurate disease diagnosis is a prerequisite for effective medication. Only 2% of overall healthcare expenditures, according to Roche Molecular Diagnostics, are spent on in vitro diagnostics, even though 60% of treatment choices are based on this data. To make LFA more innovative, futuristic plans have been outlined in many reports. Thus, this review reports on very knowledgeable literature discussing LFA and its development along with recent futuristic plans for LFA-based biosensors that cover all the novel features of the improvement of LFA. LFA might therefore pose a very significant economic success and have a significant influence on medical diagnosis.
Upper Limb Changes in DMD Patients Amenable to Skipping Exons 44, 45, 51 and 53: A 24-Month Study
Authors: Brogna Claudia , Pane Marika , Coratti Giorgia , D’Amico Adele , Pegoraro Elena , Bello Luca , Sansone Valeria , Albamonte Emilio , Messina Sonia , Pini Antonella , D’Angelo Maria , Bruno Claudio , Mongini Tiziana , Ricci Federica , Berardinelli Angela , Battini Roberta , Masson Riccardo , Bertini Enrico , Politano Luisa , Mercuri Eugenio ,   Italian DMD Group
Published: April 2023

Introduction: The Performance of Upper Limb version 2.0 (PUL 2.0) is increasingly used in Duchenne Muscular Dystrophy (DMD) to study longitudinal functional changes of motor upper limb function in ambulant and non-ambulant patients. The aim of this study was to evaluate changes in upper limb functions in patients carrying mutations amenable to skipping exons 44, 45, 51 and 53. Methods: All DMD patients were assessed using the PUL 2.0 for at least 2 years, focusing on 24-month paired visits in those with mutations eligible for skipping exons 44, 45, 51 and 53. Results: 285 paired assessments were available. The mean total PUL 2.0 12-month change was −0.67 (2.80), −1.15 (3.98), −1.46 (3.37) and −1.95 (4.04) in patients carrying mutations amenable to skipping exon 44, 45, 51 and 53, respectively. The mean total PUL 2.0 24-month change was −1.47 (3.73), −2.78 (5.86), −2.95 (4.56) and −4.53 (6.13) in patients amenable to skipping exon 44, 45, 51 and 53, respectively. The difference in PUL 2.0 mean changes among the type of exon skip class for the total score was not significant at 12 months but was significant at 24 months for the total score (p < 0.001), the shoulder (p = 0.01) and the elbow domain (p < 0.001), with patients amenable to skipping exon 44 having smaller changes compared to those amenable to skipping exon 53. There was no difference within ambulant or non-ambulant cohorts when subdivided by exon skip class for the total and subdomains score (p > 0.05). Conclusions: Our results expand the information on upper limb function changes detected by the PUL 2.0 in a relatively large group of DMD patients with distinct exon-skipping classes. This information can be of help when designing clinical trials or in the interpretation of the real world data including non-ambulant patients.
Protein Profiling in Human Papillomavirus-Associated Cervical Carcinogenesis: Cornulin as a Biomarker for Disease Progression
Authors: Kumarasamy Gaayathri , Ismail Mohd Nazri , Tuan Sharif Sharifah Emilia , Desire Christopher , Mittal Parul , Hoffmann Peter , Kaur Gurjeet
Published: April 2023

Nearly 90% of cervical cancers are linked to human papillomavirus (HPV). Uncovering the protein signatures in each histological phase of cervical oncogenesis provides a path to biomarker discovery. The proteomes extracted from formalin-fixed paraffin-embedded tissues of the normal cervix, HPV16/18-associated squamous intraepithelial lesion (SIL), and squamous cell carcinoma (SCC) were compared using liquid chromatography-mass spectrometry (LC-MS). A total of 3597 proteins were identified, with 589, 550, and 1570 proteins unique to the normal cervix, SIL, and SCC groups, respectively, while 332 proteins overlapped between the three groups. In the transition from normal cervix to SIL, all 39 differentially expressed proteins were downregulated, while all 51 proteins discovered were upregulated in SIL to SCC. The binding process was the top molecular function, while chromatin silencing in the SIL vs. normal group, and nucleosome assembly in SCC vs. SIL groups was the top biological process. The PI3 kinase pathway appears crucial in initiating neoplastic transformation, while viral carcinogenesis and necroptosis are important for cell proliferation, migration, and metastasis in cervical cancer development. Annexin A2 and cornulin were selected for validation based on LC-MS results. The former was downregulated in the SIL vs. normal cervix and upregulated in the progression from SIL to SCC. In contrast, cornulin exhibited the highest expression in the normal cervix and lowest in SCC. Although other proteins, such as histones, collagen, and vimentin, were differentially expressed, their ubiquitous expression in most cells precluded further analysis. Immunohistochemical analysis of tissue microarrays found no significant difference in Annexin A2 expression between the groups. Conversely, cornulin exhibited the strongest expression in the normal cervix and lowest in SCC, supporting its role as a tumor suppressor and potential biomarker for disease progression.
Perception and Knowledge of Algerian Students about Climate Change and Its Putative Relationship with the COVID-19 Pandemic: A Preliminary Cross-Sectional Survey
Authors: Lounis Mohamed , Madani Azzeddine , Boutebal Saad
Published: April 2023

Background: Climate changes (CC) is one of the most important insidious crises affecting all countries in the world in the 21st century, including Algeria, and it is projected to affect many people in the future. Mitigation of the effects of this phenomenon will certainly involve environmental education, especially among university students. Therefore, evaluating their level of knowledge could help us understand to what extent they are prepared to contribute in the global efforts to fight against this catastrophe. Objective: The current study aims to investigate the perception and knowledge of Algerian students about climate change and its potential relationship with the COVID-19 pandemic. Methods: An online cross-sectional survey was conducted on a sample of 204 Algerian students by adopting snowball sampling during the academic year (2022/2023), with a questionnaire based on Google Forms. Data were analyzed using SPSS software. Results: The results obtained showed that 95.6% of the students asked had heard about this phenomenon and more than 90% perceived that it was really happening. The level of knowledge is significantly associated with age, where students aged between 20 and 30 years old had a lower level of knowledge than those over 30 years old (OR = 0.22, p = 0.027). Furthermore, students of the Humanities have shown the lowest level of knowledge compared to those of other domains. Regarding their attitude, only 31.8% of the asked students declared that they changed their attitude positively during the COVID-19 pandemic. The change in attitude and concern is statistically associated neither with the level of knowledge and perception nor COVID-19 affection, psychological impact, and uptake of the COVID-19 vaccine. Conclusion: The study concluded that there was a high level of awareness and a medium level of knowledge about CC among Algerian university students. However, most of them were either very worried or a little worried about this phenomenon. It was also suggested that the average level of knowledge about cause and effect and pandemic resistance could be attributed to the scientific study path of students from the study sample. The results of this study could be used as a baseline for future research into CC knowledge and perception in Algeria.
Effect of High-Temperature Annealing on Raman Characteristics of Silicon Nanowire Arrays
Authors: Wang Shanshan , Zhang Yan
Published: April 2023

We demonstrate two distinct experimental processes involving the large-area growth of ordered and disordered silicon nanowire arrays (SiNWs) on a p-type silicon substrate using the metal-assisted chemical etching method. The two processes are based on the etching of monocrystalline silicon wafers by randomly distributed Ag films and ultra-thin Au films with ordered nano-mesh arrays, respectively, wherein the growth of SiNWs is implemented using a specific proportion of a HF-containing solution at room temperature. In this study, the microstructural change mechanisms for the two morphologically different arrays before and after annealing were investigated using Raman spectra. The effects of various mechanisms on the observed Raman scattering peak’s deviation from symmetry, redshift and broadening were analyzed. The evolution of the unstable amorphous structures of nanoscale materials during the high-temperature annealing process was observed via high-resolution scanning electron microscope (SEM) observations. The scattering peak parameters determined from the Raman spectra led to conclusions concerning the various mechanisms by which high-temperature annealing influences the microstructures of the two morphologically different SiNWs fabricated on the p-type silicon substrate. Therefore, the deviation of SiNWs from the monocrystalline silicon scattering peak at 520.05 cm−1 when changing the diameter of the nanowire columns was calculated to further analyze the effect of thermal annealing on Raman characteristics.
Development of Hetero-Junction Silicon Solar Cells with Intrinsic Thin Layer: A Review
Authors: Chuchvaga Nikolay , Zholdybayev Kairat , Aimaganbetov Kazybek , Zhantuarov Sultan , Serikkanov Abay
Published: April 2023

This paper presents the history of the development of heterojunction silicon solar cells from the first studies of the amorphous silicon/crystalline silicon junction to the creation of HJT solar cells with novel structure and contact grid designs. In addition to explanation of the current advances in the field of research of this type of solar cells, the purpose of this paper is to show possible ways to improve the structure of the amorphous silicon/crystalline silicon-based solar cells for further improvement of the optical and electrical parameters of the devices by using of numerical simulation method and current hypotheses. This paper briefly describes the history, beginning from the first studies of and research of HJT-structure solar cells. It raises questions about the advantages and existing problems of optimization of HJT solar cells. The authors of this paper are proposing further ways of design development of HJT solar cells.
A Study of the Laser-Assisted Alloying Effect on Plasmonic Properties of Au-Pd Nanostructured Film Using Surface-Enhanced Raman Spectroscopy
Authors: Awada Chawki , Ruffino Francesco
Published: April 2023

In this work, we report a study on the effect of the laser-assisted alloying effect on plasmonic properties of Pd and Au-Pd nanostructures using surface-enhanced Raman spectroscopy (SERS). The monometallic and bimetallic nanostructures are formed by nanosecond-laser induced de-wetting and the alloying of pure Pd and bimetallic Au-Pd nanoscale-thick films deposited on a transparent and conductive substrate. The morphological characteristics of the nanostructures were changed by controlling the laser fluence. Then, 4-nitrithiophenol (4-NTP) was used as an adsorbed molecule on the surface of the nanostructures to analyze the resulting SERS properties. A quantitative analysis was reported using the SERS profile properties, such as FWHM, amplitude, and Raman peak position variation. An excellent correlation between the variation of SERS properties and the nanostructures’ size was confirmed. The optical enhancement factor was estimated for Pd and Au-Pd nanostructures for the laser fluence (0, 0.5, 0.75, 1, and 1.5 J/cm2).
Effect of Pre-Germinative Treatments on Eight Priority Native Species for Reforestation in the Tropical Deciduous Forest
Authors: De Jesús-Velázquez Juan , Cisneros-Villaseñor Alejandro , Tamayo-Bustamante Ricardo Armando , Girón-Gutiérrez Dioseline , Luna-Soria Hugo , Cambrón-Sandoval Víctor Hugo
Published: April 2023

Increasing the germination percentages from chemical and/or mechanical processes in native species is vital for the conservation of the species. The objective was to evaluate the effect of different treatments on the germination process of species belonging to the tropical deciduous forest (TDF) in a forest nursery. Eight species of trees and shrubs reported to be native to the TDF were selected; the seeds were collected from various sites of the state of Queretaro, Mexico. A randomized design of four replicates with 25 seeds was used, for which three pre-germinative scarification treatments were evaluated for each species: (1) thermal scarification (TS), (2) mechanical scarification (MS), and (3) chemical scarification (CS). Germination was considered as the protrusion of cotyledons onto the substrate and was recorded every 48 h for 60 days. A significant difference was observed between treatments (p ≤ 0.05). The mechanical treatment (MS) obtained the highest germination percentage and the least variation, in contrast to the thermal, chemical, and control treatments, which presented the lowest amount of germinated seeds. The MS treatment was the most effective for all the species studied because it allowed for 100% of the germination to be achieved.
Crystal Structures of 3,3′,5,5′-Tetrabromo-4,4′-bipyridine and Co(II) Coordination Polymer Based Thereon
Authors: Sakhapov Ilyas F. , Zagidullin Almaz A. , Dobrynin Alexey B. , Litvinov Igor A. , Yakhvarov Dmitry G. , Bondarenko Mikhail A. , Novikov Alexander S. , Fedin Vladimir P. , Adonin Sergey A.
Published: April 2023

The crystal structure of 3,3′,5,5′-tetrabromo-4,4′-bipyridine (BrBipy, 1) was determined, and the features of non-covalent interactions in solid state were investigated by theoretical methods. Using BrBipy as a linker ligand, 1D coordination polymer {[Co(BrBipy)(NO3)2(CH3OH)2]} (2) was obtained and characterized.
‘Targeting’ Improved Outcomes with Antibody-Drug Conjugates in Non-Small Cell Lung Cancer—An Updated Review
Authors: Verma Saurav , Breadner Daniel , Raphael Jacques
Published: April 2023

Antibody-Drug conjugates (ADCs) are a relatively new class of drugs with a promise to improve the outcomes in specific cancers. By delivering the cytotoxic agent to tumor cells expressing specific antigens, ADCs achieve a better therapeutic index and more potency. ADCs have been approved for several hematological and solid malignancies, including breast, urothelial and gastric carcinoma. Recently, trastuzumab deruxtecan (TDXd) was the first ADC approved for previously treated metastatic HER2-mutant non-small cell lung cancer (NSCLC). Many promising ADCs are in the pipeline for clinical development in non-small cell lung cancer, including sacituzumab govitecan, patritumab deruxtecan, datopotamab deruxtecan and tusamitamab ravtansine. There is a hope that these drugs would cater to the unmet need of specific patient populations, including patients with currently untargetable mutations. We hope these drugs, e.g., TROP2 targeted ADCs, will also give more options for therapy in NSCLC to improve outcomes for patients. In this comprehensive review, we will be discussing the recent evidence including targets, efficacy and the safety of newer ADC candidates in NSCLC. We will also briefly discuss the specific toxicities, novel biomarkers, overcoming resistance mechanisms, challenges and the way forward, as these new ADCs and combinations find a way into the clinical practice.
Exploration Behaviour of European Bison (Bison bonasus) after Its Reintroduction to Żednia Forest District in North-Eastern Poland
Authors: Sobczuk Maria , Klich Daniel , Uciechowska-Grakowicz Anna , Olech Wanda
Published: April 2023

Reintroduction of European bison into the natural environment is one of the most important conservation measures applied for this species. After creating a free herd of European bison, spatial monitoring is crucial. It allows for observation of the population, as well as the detection of potential threats and needs for intervention. In 2016, a new free herd of European bison was introduced to the Żednia District in Knyszyńska Forest. After a few months spent in the acclimation enclosure, the animals were released. The course of their acclimatisation was observed with GPS collars during the next 7 years. Thanks to telemetry monitoring, we could determine the moment when the herd stabilised its home range within available habitats. Monitoring performed for 7 years after the release of the herd confirmed the previously established home range. The fact that the animals remain close to the release site and that there is no damage to the winter crops confirms that the reintroduction site was well chosen.
Initial Population Analysis and Mycorrhizal Fungi of the Leafless Epiphytic Orchid, Campylocentrum pachyrrhizum, in Florida
Authors: Herdman Adam R. , Mújica Ernesto B. , Danaher Mark W. , Zettler Lawrence W. , Schulz Kurt , Esselman Elizabeth
Published: April 2023

Campylocentrum pachyrrhizum Rchb.f. Rolfe, also known as the ribbon orchid, is native to southern Florida, the West Indies, and northern South America. In Florida, it is restricted to the Fakahatchee Strand and is currently state-listed as endangered, but virtually nothing is known about the orchid’s biology, ecology, and current status. The purpose of this study was to document ribbon orchid populations within the northern portion of the Fakahatchee Strand (Florida Panther NWR) and to identify some of the biotic and abiotic factors critical to its survival. During 2016–2022, a total of 118 ribbon orchids were recorded at five sites on 21 host trees comprising two species (Annona glabra, Fraxinus caroliniana). The majority (80%) were rooted on pop ash, and over half (54%) were rooted at the base of trees 100–150 cm above the high water mark. The number of orchids decreased from year to year, with the largest drop (2017–2018) coinciding with damage from Hurricane Irma. At the end of the 2022 survey, only 44 orchids remained. Mycorrhizal fungi isolated from two plants were identified as a Ceratobasidium species. We urge land managers to take immediate action to safeguard this species throughout southern Florida.
Digital Twin Application and Bibliometric Analysis for Digitization and Intelligence Studies in Geology and Deep Underground Research Areas
Authors: Ahn Eun-Young , Kim Seong-Yong
Published: April 2023

As deep underground digital twins have not yet been established worldwide, this study extracted keywords from national or city-led digital twin practices and elements of digital twins and through these keywords selected research papers and topics that could contribute to the establishment of deep underground digital twins in the future. We applied the concept of digital twins in geology and underground research to collect 1702 papers from the Web of Science and conducted semantic network analysis and topic modeling. The keywords digital, three dimensions, and real time were placed in the middle and have many links in the word network. Artificial intelligence, deep learning, and neural networks all showed a low degree of centrality. As a result of topic modeling using Latent Dirichlet allocation (LDA), topics related to topography, geological structure, and rock distribution, which are the basic data for building a deep underground digital twin, were noted, and topics related to earthquakes/vibrations, landslides, groundwater, and volcanoes were identified. Energy resources and space utilization have emerged as the main themes.
Idiopathic Granulomatous Mastitis or Breast Cancer? A Comparative MRI Study in Patients Presenting with Non-Mass Enhancement
Authors: Soylu Boy Fatma Nur , Esen Icten Gul , Kayadibi Yasemin , Tasdelen Iksan , Alver Dolunay
Published: April 2023

Objective: To compare and determine discriminative magnetic resonance imaging (MRI) findings of idiopathic granulomatous mastitis (IGM) and breast cancer (BC) that present as non-mass enhancement. Materials and Methods: This retrospective study includes 68 IGM and 75 BC cases that presented with non-mass enhancement on breast MRI. All patients with a previous history of breast surgery, radiotherapy, or chemotherapy due to BC or a previous history of mastitis were excluded. On MRI images, presence of architectural distortion skin thickening, edema, hyperintense ducts containing protein, dilated fat-containing ducts and axillary adenopathies were noted. Cysts with enhancing walls, lesion size, lesion location, fistulas, distribution, internal enhancement pattern and kinetic features of non-mass enhancement were recorded. Apparent diffusion coefficient (ADC) values were calculated. Pearson chi-square test, Fisher’s exact test, independent t test and Mann–Whitney U test were used as needed for statistical analysis and comparison. Multivariate logistic regression model was used to determine the independent predictors. Results: IGM patients were significantly younger than BC patients (p < 0.001). Cysts with thin (p < 0.05) or thick walls (p = 0.001), multiple cystic lesions, (p < 0.001), cystic lesions draining to the skin (p < 0.001), and skin fistulas (p < 0.05) were detected more often in IGM. Central (p < 0.05) and periareolar (p < 0.001) location and focal skin thickening (p < 0.05) were significantly more common in IGM. Architectural distortion (p = 0.001) and diffuse skin thickening (p < 0.05) were associated with BC. Multiple regional distribution was more common in IGM, whereas diffuse distribution and clumped enhancement were more common in BC (p < 0.05). In kinetic analysis, persistent enhancement was more common in IGM, whereas plateau and wash-out types were more common in BC (p < 0.001). Independent predictors for BC were age, diffuse skin thickening and kinetic curve types. There was no significant difference in the diffusion characteristics. Based on these findings, MRI had a sensitivity, specificity and accuracy of 88%, 67.65%, and 78.32%, respectively, in differentiating IGM from BC. Conclusions: In conclusion, for non-mass enhancement, MRI can rule out malignancy with a considerably high sensitivity; however, specificity is still low, as many IGM patients have overlapping findings. Final diagnosis should be complemented with histopathology whenever necessary.
New Technologies in the Assessment of Carotid Stenosis: Beyond the Color-Doppler Ultrasound—High Frame Rate Vector-Flow and 3D Arterial Analysis Ultrasound
Authors: David Emanuele , Martinelli Ombretta , Pacini Patrizia , Di Serafino Marco , Huang Pintong , Dolcetti Vincenzo , Del Gaudio Giovanni , Barr Richard G. , Renda Maurizio , Lucarelli Giuseppe T. , Di Marzo Luca , Clevert Dirk A. , Solito Carmen , Di Bella Chiara , Cantisani Vito
Published: April 2023

Atherosclerotic plaque in the carotid artery is the main cause of ischemic stroke, with a high incidence rate among people over 65 years. A timely and precise diagnosis can help to prevent the ischemic event and decide patient management, such as follow up, medical, or surgical treatment. Presently, diagnostic imaging techniques available include color-Doppler ultrasound, as a first evaluation technique, computed tomography angiography, which, however, uses ionizing radiation, magnetic resonance angiography, still not in widespread use, and cerebral angiography, which is an invasively procedure reserved for therapeutically purposes. Contrast-enhanced ultrasound is carving out an important and emerging role which can significantly improve the diagnostic accuracy of an ultrasound. Modern ultrasound technologies, still not universally utilized, are opening new horizons in the arterial pathologies research field. In this paper, the technical development of various carotid artery stenosis diagnostic imaging modalities and their impact on clinical efficacy is thoroughly reviewed.
Mandibular Reconstruction after Resection of Ameloblastoma by Custom-Made CAD/CAM Mandibular Titanium Prosthesis: Two Case Reports, Finite Element Analysis and Discussion of the Technique
Authors: Cortese Antonio , Spirito Francesca , Claudio Pier Paolo , Lo Muzio Lorenzo , Ruggiero Alessandro , Gargiulo Maurizio
Published: April 2023

Virtual surgical planning for CAD/CAM mandibular reconstruction by titanium prosthesis was recently reported for resected cases. Even if some advantages are evident, difficulties that may arise for TMJ function after reconstruction originate from prosthesis contamination through oral mucosa dehiscence. In these two cases reported of mandibular reconstruction after resection of ameloblastoma by custom-made CAD/CAM titanium prosthesis, the procedures were aimed to preserve the TMJ glenoid cavity and articular disc avoiding functional problems for hemi-mandibular resections that included the condyle (as in case #1) or with condylar preservation (as in case #2) and avoiding intraoral incisions in both cases. The entire surgical planning and prosthetic fabrication were explained with specifications and the sequence of the surgical procedure. Finite elements analysis (FEA) was performed to check the force distribution and efficacy of the prosthetic device (case 1 with hemi-mandibular resection and rehabilitation). Although successful in these two cases, surgical reconstruction of the mandibular defect after resection by a CAD-CAM custom-made prosthesis still shows some drawbacks and failure risks. Several advantages of this technique and the surgical success in these two cases were presented, but limitations and side effects must be considered when cases are selected.
Network Synchronization of MACM Circuits and Its Application to Secure Communications
Authors: Méndez-Ramírez Rodrigo , Arellano-Delgado Adrian , Murillo-Escobar Miguel Ángel
Published: April 2023

In recent years, chaotic synchronization has received a lot of interest in applications in different fields, including in the design of private and secure communication systems. The purpose of this paper was to achieve the synchronization of the Méndez–Arellano–Cruz–Martínez (MACM) 3D chaotic system coupled in star topology. The MACM electronic circuit is used as chaotic nodes in the communication channels to achieve synchronization in the proposed star network; the corresponding electrical hardware in the slave stages receives the coupling signal from the master node. In addition, a novel application to the digital image encryption process is proposed using the coupled-star-network; and the switching parameter technique is finally used to transmit an image as an encrypted message from the master node to the slave coupled nodes. Finally, the cryptosystem is submitted to statistical tests in order to show the effectiveness in multi-user secure image applications.
Spatio-Temporal Analysis of Marine Water Quality Data Based on Cross-Recurrence Plot (CRP) and Cross-Recurrence Quantitative Analysis (CRQA)
Authors: Li Zhigang , Sun Ting , Wang Yu , Liu Yujie , Sun Xiaochuan
Published: April 2023

In recent years, with the frequency of marine disasters, water quality has become an important environmental problem for researchers, and much effort has been put into the prediction of marine water quality. The temporal and spatial correlation of marine water quality parameters directly determines whether the marine time-series data prediction task can be completed efficiently. However, existing research has only focused on the correlation analysis of marine data in a certain area and has ignored the temporal and spatial characteristics of marine data in complex and changeable marine environments. Therefore, we constructed a spatio-temporal dynamic analysis model of marine water quality based on a cross-recurrence plot (CRP) and cross-recurrence quantitative analysis (CRQA). The time-series data of marine water quality were first mapped to high-dimensional space through phase space reconstruction, and then the dynamic relationship among various factors affecting water quality was visually displayed through CRP. Finally, their correlation was quantitatively explained by CRQA. The experimental results showed that our scheme demonstrated well the dynamic correlation of various factors affecting water quality in different locations, providing important data support for the spatio-temporal prediction of marine water quality.
Stochastic Ordering of Stationary Distributions of Linear Recurrences: Further Results and Economic Applications
Authors: Di Pietro Christian , Pietroluongo Mariafortuna , Sorge Marco
Published: April 2023

We investigate pairwise stochastic comparisons of stationary solutions to the linear recurrence Xt+1=AtXt+Bt, where At and Bt are non-negative random variables. We establish novel order-preserving properties, which enable us to obtain comparison theorems about well-known measures of conditional size, tail variability and skewness across probability distributions. While useful in studies of ergodic wealth accumulation processes and the persistence of inequality, our results can fruitfully be exploited to conduct comparative statics exercises in structural models entailing Kesten-type reduced-form representations. An application of our analysis to a dynamic asset accumulation model uncovers the qualitatively similar effects of capital income and earnings taxation on expected wealth concentration over higher quantiles as well as on conditional upper tail dispersion of wealth holdings, qualifying previous results that solely rely on the determination of Pareto exponents.
Undergraduate Students’ Conceptualization of Critical Thinking and Their Ideas for Critical Thinking Acquisition
Authors: Pnevmatikos Dimitrios , Christodoulou Panagiota , Georgiadou Triantafyllia , Lithoxoidou Angeliki
Published: April 2023

Higher education institutions are responsible for preparing and equipping undergraduate students with the skills required by the labor market, such as critical thinking. However, academics should consider students’ pre-existing ideas before designing and implementing an instructional intervention regarding critical thinking. Drawing on the literature for conceptual change, the current study aimed to map students’ conceptualization of critical thinking and their ideas regarding the acquisition of critical thinking. In total, 243 first-year social sciences students participated in the study. To explore students’ ideas, the authors constructed an instrument with 20 scientific and non-scientific statements about critical thinking. The instrument was a two-tier questionnaire, and participants indicated their level of agreement with each statement using a 5-point Likert scale as well as their confidence in their answers. Students’ ideas were categorized into six groups depending on their endorsements for the statement and their level of confidence in their decision. Results revealed that students had insufficient conceptualization of critical thinking, and their ideas regarding how critical thinking might be acquired were not consistently aligned with those of academics. Implications for instruction are discussed considering students’ ideas on critical thinking.
Arab Teachers’ Well-Being upon School Reopening during COVID-19: Applying the Job Demands–Resources Model
Authors: Awwad-Tabry Sawsan , Levkovich Inbar , Pressley Timothy , Shinan-Altman Shiri
Published: April 2023

Once the major threat of the COVID-19 pandemic diminished, schools reopened, and teachers once again had to cope with unprecedented challenges. The impact of these challenges on the emotional well-being of Arab teachers, who have a unique set of challenges within the Israeli school educational system, has received little attention in the recent literature. In this cross-sectional study, we examined 300 Arab teachers’ well-being in Israel in May 2021, three months after schools were reopened. All study hypotheses were confirmed. Findings indicate the need to promote a sense of well-being among Arab teachers in stressful conditions and to design solutions specifically tailored to support them in accordance with their cultural and social characteristics. Israel’s Ministry of Education should encourage school administrators to seek ways to provide a supportive environment for Arab teachers in school environments in order to improve their performance and retention, and maintain their well-being.
A Review–Unguided Optical Communications: Developments, Technology Evolution, and Challenges
Authors: Raj A. Arockia Bazil , Krishnan Prabu , Darusalam Ucuk , Kaddoum Georges , Ghassemlooy Zabih , Abadi Mojtaba Mansour , Majumdar Arun K. , Ijaz Muhammad
Published: April 2023

This review paper discusses the complete evolution of free-space optical (FSO) communication, also known as unguided optical communication (UOC) technologies, all the way back to ancient man’s fire to today’s machine-learning-supported UOC systems. The principles, significance, and developments that have happened over the past several decades, as well as installation methodologies, technological limitations, and today’s challenges of UOCs are presented. All the subsets of UOC: FSO communication, underwater optical wireless communication (UOWC), and visible light communication (VLC), with their technology/system developments, potential applications, and limitations are reviewed. The state-of-the-art developments/achievements in (i) FSO channel effects and their mitigation techniques; (ii) radio-over-FSO techniques; (iii) wavelength division multiplexing and sub-carrier multiplexing techniques; (iv) FSO for worldwide interoperability for microwave access applications; (v) space optical satellite communication (SOSC); (vi) UWOC; (vii) photoacoustic communication (PAC); (viii) light-fidelity; (ix) VLC; (x) vehicular VLC (V2LC); and (xi) optical camera communication are reviewed. In addition, the current developments on emerging technologies such as artificial intelligence (to improve the performance of UOC systems), energy harvesting (for the effective utilization of UOC channels), and near-future communication network scenarios (mandatory for secured broadband digital links) are covered. Finally, in brief, to achieve the full potential of UOC systems, challenges that require immediate research attention are summarized.
Methodology for an Audit of Institutional Projects in the Energy Sector
Authors: Fedchenko Elena , Gusarova Lyubov , Timkin Timur , Gryzunova Natalie , Bilczak Michał , Frumina Svetlana
Published: April 2023

Auditing activity, in the last decade, is one of the most dynamically changing types of economic activity, on the one hand, due to an increase in the number of state projects implemented by many countries, and on the other hand, due to technological innovations and digitalization. Russian auditing practices are also being actively reformed. For example, the Ministry of Energy is updating their audit methodology. The subject of this study is to ensure the efficiency of spending public funds for the implementation of strategic projects. The object of this study is the methodology of a state audit. An analysis of the currently used Russian and international standards for public audits shows that there are many opportunities to improve the methodology for conducting financial, strategic and performance audits. First of all, there is a need to solve methodological problems in monitoring the efficiency of investment developments, since partnerships between private investors and government bodies for the implementation of strategic projects have expanded. The main difficulty of audit methodology is the definition of a system of target criteria in long-term projects. Quite often it is difficult to determine the main expected result, for example, financial, or social efficiency or the adequacy of multi-unit tariffs. All these circumstances determine the relevance of methodological changes. The aim of this study is to develop a new audit methodology as, first of all, a management technology. We use a result-oriented approach that is based on the developed system of indicators, to evaluate the effectiveness of an institutional project and to evaluate the effectiveness of environmental costs and technological innovations to reduce anthropogenic emissions and to create a single Asian energy space.