bluuebunny/crossref_metadata_2025 huggingface dataset:
Measuring the Manasika Prakrti of the Children by the Parent Rating Scale
Authors: Suchitra S. P. , Nagendra H. R.
Published: August 2024

Background:

Inventories to asses guna personality have been developed and validated for adults. However, are not based on Ayurveda concepts. The objective of the study was to develop and standardize an inventory to assess the Manasika prakrti of the children according to Ayurveda.

Methods:

The 70-item Ayurveda guna inventory for children (AGIC) was developed on the basis of the translation of Sanskrit verses describing Sattva (A), Rajas (B), and Tamas prakrti (C) characteristics and by taking the opinions of experts (ten Ayurveda experts and three psychologists). The scale was tested out in Maxwell Public School, Bangalore. The scale was administered on parents of children of the age group 6–12 years.

Results:

The AGIC was associated with excellent internal consistency. The Cronbach’s alpha for the A-, B-, and C-scales was 0.80, 0.55, and 0.56, respectively. Moreover, the split-half reliability was 0.79, 0.56, and 0.64, respectively. Factor validity coefficient scores on each item were above 0.5 on the Sattva, Rajas, and Tamas scale.

Conclusions:

The Manasika prakrti (trigunas) of the children can be measured reliably by this instrument.
Flu-like symptoms following botulinum toxin A application before incisional hernia repair: A case report
Authors: Kulacoglu Hakan , Alptekin Alp , Celasin Haydar
Published: August 2024

Botulinum toxin has been used for the treatment of numerous medical conditions. Recently, preoperative botulinum toxin A (BTA) injections into the lateral abdominal wall muscles are beneficial for facilitating ventral hernia repairs and improving surgical outcomes. Early and late, local and systemic adverse effects of BTA application have been described, some of them are flu-like symptoms (FLS). However, no case of FLS following botulinum toxin injections before ventral hernia repair has been described. In this report, we present a 58-year-old female patient who developed FLS episodes throughout preoperative and postoperative periods following BTA injections.
Nursing Care Challenges for Patients Suffering from COVID-19 from Nurses' Perspective in Iran: A Descriptive Qualitative Study
Authors: Atashi Vajiheh , Safazadeh Shima , Taleghani Fariba , Sami Ramin , Ahmadi Shokoufeh , Pourkermanian Pourandokht
Published: August 2024

Background:

Encountering the coronavirus disease 2019 (COVID-19) pandemic, nurses face many challenges due to various strategies and resources that can compromise the quality of care. This study aimed to identify nursing care challenges for patients with COVID-19 from nurses' viewpoint in Iran.

Materials and Methods:

This descriptive qualitative study was conducted in one of the main admission centers in Isfahan to treat patients with COVID-19. Data were collected through semi-structured in-depth interviews with 19 nurses from April 2020 to June 2020. The recorded interviews were transcribed and then analyzed through inductive content analysis.

Results:

The challenges of nursing care for patients infected with COVID-19 from the nurses' viewpoint were categorized into 11 subcategories and four main categories: work overload in disaster (lack of nurses with adequate clinical qualification and restrictions on the compliance of the infection control protocols), immersion in an ocean of psychological and social tensions (personal and family tensions, work environment tensions, perception of organizational injustice, and social stigma), quality of care in fragile condition (self-preservation rather than patient care and contradictory patient care standards), and disaster preparedness, response, and management (passive resource management, information system challenges, and lack of guideline-supported protocols).

Conclusions:

The findings of this study suggest that policymakers should actively participate in supporting nurses in the form of reducing physical and mental stress in pandemics such as COVID-19. Having the right perception of the challenges nurses face in such crises can contribute to providing patient safety, improving the quality of care, maintaining organizational resources, and properly managing the disaster.
Structural Model of Family Caregiver for Elderly with Dementia
Authors: Sya'diyah Hidayatus , Nursalam Nursalam , Mahmudah Mahmudah , Efendy Ferry
Published: August 2024

Background:

The number of older people with dementia was continuously increasing globally. Unfortunately, many of them had received inappropriate medical treatment to overcome the dementia they suffered. This current research aimed to analyze the factors that affected family-based caregiver empowerment.

Materials and Methods:

An analytic observational method with a cross-sectional approach was applied. The population was all families with dementia elderly in East Java, Indonesia, in 2021, who met the inclusion and exclusion criteria. The sample size was determined to be 100 respondents.

Results:

The results showed that the factors (i.e., elderly factors, family factors, health service factors, family's filial value, family assessment, and the need for care) had significant effects directly or indirectly on the family's ability to do home care.

Conclusions:

Factors that influenced directly (i.e., elderly factors, family factors, family assessment, and care needs) and indirectly (i.e., health service factors) were essential in constructing a structural model of family care for the elderly with dementia.
Comparing the Effect of Premature Infant Care Training and Performing Auriculotherapy Techniques on Anxiety, General Self-Efficacy and Breastfeeding Self-Efficacy of Mothers with Premature Infants
Authors: Rabiee Niloofar , Ghasempour Zahra , Abolhassani Moussa , Haghighi Nahid Bolbol
Published: August 2024

Background:

A preterm birth exposes the mother to many challenges in caring for and supporting the baby. This study aims to use training and auriculotherapy techniques as two simple methods to reduce anxiety and increase the mother's self-efficacy.

Materials and Methods:

This single-blind three-group clinical trial study was conducted in the Bahar Hospital in Shahroud, Iran, in 2019. The target group of primiparous mothers was premature infants. For the first group, premature infant care training was provided, and for the second group, auriculotherapy techniques were performed, and the third group (the control group) received routine care. Anxiety, general self-efficacy, and maternal breastfeeding self-efficacy were measured at the beginning of the study and before neonatal discharge.

Results:

Before the intervention, three groups were not significantly different in demographic characteristics, obvious and hidden anxiety scores, and general self-efficacy and lactation (p > 0.05). There was a significant difference between the control group and the two intervention groups with ANOVA test for self-efficacy (F2,87 = 6.60, p = 0.002), breastfeeding self-efficacy (F2,87 = 15.20, p < 0.001), obvious anxiety (F2,87 = 56.20, p < 0.001), hidden anxiety (F2.87 = 62.90, p < 0.001), after the intervention. In addition, there was no significant difference in the length of hospital stay in the neonatal intensive care unit (p = 0.732). Still, the neonate's infant's mean weight before discharge in the two intervention groups was significantly different from the control group (p = 0.034).

Conclusions:

Teaching mothers how to care for premature infants and implement auriculotherapy techniques reduces anxiety and increases mothers' general self-efficacy and breastfeeding.
Informal Caregivers and Care Burden in Iran: Systematic Review and Meta-Analysis
Authors: Amiresmaili Mohammadreza , Goudarzi Reza , Agoush Leila
Published: August 2024

Background:

The increase in the average age of the population, the decrease in the size of the household and rising in the number of working women impose an increasing burden on home caregivers in Iran. The aim of this study was to measure care burden of informal caregivers in Iran through systematic review and meta-analysis of existing literature.

Materials and Methods:

A systematic review was conducted by using national and international databases of Scopus, PubMed, Embase, Web of Science, SID, Magiran, and IranDoc papers in English and Persian language up to the first half of 2020. In this meta-analysis, we calculated the pooled care burden and 95% confidence intervals in Statistical Software For Data Science (STATA) V.15.

Results:

Forty-four papers were included in the current study based on inclusion and exclusion criteria comprising of 8626 samples. Pooled mean of Burden of Care was 52.01 (95% CI: 48.21-55.82). Highest pooled mean(SD) of care burden (64.37) was related to caregivers of schizophrenia patients (95% CI: 56.09–72.64). Highest care burden (53.45) was observed in most deprived areas (95%CI = 47.05–59.86). A statistically significant relationship was observed between caregivers gender and care burden (p < 0.05).

Conclusions:

The reported care burden of informal caregivers requires the establishment of a support system to control mental and physical stress. Due to the dispersion and cultural diversity in Iran, more studies are needed to obtain more accurate data.
Knowledge, Attitudes, and Anxiety of Midwives Toward Maternal Care During the COVID-19 Pandemic: A Descriptive Study on Midwives Who Experience the Perinatal and Breastfeeding Phases
Authors: Ocktariyana  , Lestari Dian
Published: August 2024

Background:

People all over the world, including pregnant women, have experienced stress and anxiety due to the coronavirus disease 2019 (COVID-19) pandemic. Providing services during the pandemic is something that midwives in primary health care cannot avoid. This study assesses a midwife's knowledge, attitude, and anxiety toward providing maternal care during the pandemic.

Material and Method:

A cross-sectional design was used in this study, which involved 183 midwives who provided midwifery services at hospitals and health centers and had experience with the perinatal and breastfeeding phases. Using the Google Forms tool, respondents completed a questionnaire regarding their knowledge, attitudes, and anxiety toward maternal care during the COVID-19 pandemic.

Results:

One hundred eighty-two midwives (99.50%) understood maternal care well during the COVID-19 pandemic. In addition, the maternal care provided during the COVID-19 pandemic was viewed favorably by almost all the participants. The percentage of midwives working in primary care in the perinatal phase who had moderate-to-severe anxiety levels during the COVID-19 pandemic was 17 women (27.42%).

Conclusions:

The knowledge and attitudes of midwives about the COVID-19 pandemic in this study were good, and there was a smaller percentage of midwives with an extreme level of anxiety.
Evaluation of effect of various drinks on tooth surface morphology under scanning electron microscope
Authors: Dixit Seema , Goyal Siddhi , Singh Anshdeep , Dhingra Anil , Grover Sheetal , Gupta Pulkit
Published: August 2024

Aim and Objectives:

The study aimed to evaluate and compare the effect of various beverages carbonated drinks, i.e., thumps up, fresh fruit juice (apple and pomegranate) and packaged fruit juice (apple and pomegranate) on tooth surface morphology under scanning electron microscope.

Materials and Methods:

Thirty recently extracted intact caries-free human permanent teeth were disinfected with 5.25% of sodium hypochlorite solution and autoclaved at 240°F, 20 psi pressure for 40 min. Each tooth was sectioned into 4 enamel sections yielding 120 sections which were embedded in resin using a prefabricated mold. Prepared samples were immersed as Group I - thumps up, Group II - fresh apple juice, Group III - packaged apple juice, Group IV - fresh pomegranate juice, Group V - packaged pomegranate juice, and Group VI - normal saline. Each immersion was done daily for 30 min over 14 days after which samples were scanned under scanning electron microscope (SEM). The data obtained were subjected to statistical analysis using Statistical Package for the Social Sciences (SPSS Version 23; Chicago Inc., IL, USA).

Results:

The highest surface roughness was noted in the fresh pomegranate and packaged pomegranate groups with a mean of 2.9000 ± 0.30779 followed by thumbs up group. The greatest mean of cracks was noted in thumbs up group with a mean of 2.500 ± 0.51299 which was significant at P = 0.000. The greatest mean of score was noted in thumbs up group with a mean of 2.3000 ± 0.65695 which was significant at P = 0.000.

Conclusion:

The present study demonstrated that all drinks were erosive in nature with thumps and pomegranate juice showing significantly higher erosiveness than apple juice (P < 0.01).
Quantitative evaluation of the apically extruded debris from root canals prepared by single-file rotary and reciprocating file systems: An in vitro study
Authors: Sharma Ayisha , Nirupama Duddi Narendra , Nainan Mohan Thomas , Vijay R. , Thomas Helen , Yasin Sohail
Published: August 2024

Aim:

The aim is to investigate and compare the amount of apically extruded debris after root canal preparation using single rotary and reciprocating file system.

Materials and Methods:

Forty single-rooted human mandibular premolars with straight canals were randomly assigned to four groups (n = 10). The root canals were instrumented according to the manufacturers’ instructions using single-rotary file systems Hyflex EDM (HEDM), One Shape (OS) and single-reciprocating file systems Wave OneGold (WOG) and OneRECI (OR). The apically extruded debris was collected in preweighed glass vials using the Myers and Montgomery method. After drying, the mean weight of the extruded debris was assessed using a microbalance.

Results and Conclusions:

Multiple comparison between groups demonstrated that the mean weight of apically extruded debris in the HEDM group was significantly less compared to all other study groups, and the differences were statistically significant (P < 0.001). Under the condition of this study, all file systems caused apical debris extrusion. The mean apically extruded debris was significantly least in HEDM, followed by WOG, OneRECI and highest in the OS group.
Comparative evaluation of dual-cure resin (TheraCal PT) and Biodentine in coronal pulpotomy of patients with symptoms indicative of irreversible pulpitis: A randomized clinical trial
Authors: Baranwal Harakh Chand , Mittal Neelam , Samad Silviya , Ayubi Aiyman , Aggarwal Harshitaa , Kharat Shubham M.
Published: August 2024

Background:

New and innovative materials are being marketed for the treatment of coronal pulpotomy. It is crucial to compare their efficacy with already-established materials. TheraCal PT (TP) is such a new material that studies are scarce.

Aim:

This study aim to compare and evaluate the outcome of coronal pulpotomy using Biodentine and a newly introduced calcium silicate-based dual-cure resin cement, TP, in patients with symptoms of irreversible pulpitis.

Materials and Methods:

Sixty patients with exposed carious pulp and symptomatic irreversible pulpitis were included, aged 18–40, randomly allocated to two groups: TP (group I) and Biodentine (group II). Coronal pulpotomy was performed following a standardized protocol, with TP or Biodentine applied accordingly. The pain was recorded using Visual Analog Scale preoperatively for up to 1 week. Success was assessed clinically and radiographically for up to 12 months.

Statistical Analysis Used:

The data were analyzed using the Friedman test and the Mann–Whitney U-test. Intragroup pain was analyzed using the Wilcoxon signed-rank test.

Results:

Among 60 patients, intervention was done in 53. By removing dropout patients, 47 were analyzed, with 38 available for follow-up at 3, 6, and 12 months. The Biodentine group exhibited a 12-month success rate of 84%, while the TP group revealed 77.3%, with statistically insignificant difference (P = 0.563).

Conclusion:

TP can be effectively utilized as a pulpotomy material in cases of symptomatic irreversible pulpitis in mature permanent teeth, offering rapid setting and ease of use, although Biodentine yielded slightly better results in this study.
Influence of diode laser irradiation on microtensile bond strength of etch-and-rinse adhesive to dentin using two different etchants: An in vitro study
Authors: Naik Asmita Sadanand , De Ataide Ida De Noronha , Fernandes Marina
Published: August 2024

Aim:

The aim of this study was to evaluate the influence of 970 nm diode laser (DL) irradiation on the microtensile bond strength (µTBS) of etch-and-rinse adhesive (ERA) to dentin using phosphoric acid (PA) or alpha-hydroxy glycolic acid (GA) as etchants.

Materials and Methods:

A total of 32 human third molars were selected and assigned randomly among two different groups and four subgroups based on etching protocols and DL irradiation: PA, PA-DL, GA, and GA-DL. After tooth preparation and subsequent incremental composite build-up, the samples were stored in distilled water for 24 h at 37°C. µTBS values were obtained using the universal testing machine. The failure modes observed in dentin were categorized as adhesive, cohesive within dentin/resin, or mixed.

Statistical Analysis:

The data were analyzed using one-way analysis of variance, followed by Tukey’s post hoc test (P ≤ 0.001).

Results:

GA showed better or similar bond strength values to PA. Furthermore, irradiation of DL increased the µTBS to dentin when both PA or GA are used as etchants.

Conclusion:

GA can be used as an alternative etchant to PA. DL irradiation stands as a promising approach for elevating the performance of ERA adhesive systems to dentin.
Spectrophotometric evaluation of color stability of novel composites following exposure to antioxidant beverages: An in vitro study
Authors: Priya Bharti , Arora Anshul , Taneja Sonali
Published: August 2024

Background:

Color matching and stability are the essential considerations in restorative dentistry, as they contribute to the longevity and esthetic appeal of the restorations. Composites with nanoparticles and more filler content are anticipated to be more color-stable.

Aim:

The aim of the study was to assess and contrast the color stability of esthetic restoration materials following exposure to various antioxidant beverages.

Materials and Methods:

A Class V cavity was prepared on the buccal surface of 40 maxillary premolars. The specimens were divided into two groups: microhybrid (MH) and nanohybrid (NH) composite. The baseline color of each tooth sample was measured and then, the samples were categorized into four subgroups based on the immersion solution (pomegranate juice, beetroot juice, black plum juice, and distilled water) and evaluated on day 1, day 7, day 14, and day 21 using a spectrophotometer-based on CIE L*a*b* color scale. For spectrophotometer analysis, CIE XYZ data were obtained and converted to CIELAB. The samples mean difference in ΔE values before and after being immersed in various beverages.

Statistical Analysis:

The data were statistically analyzed using an independent t-test and one-way analysis of variance.

Results:

MH and NH composite materials showed color change after being exposed to the test beverages.

Conclusion:

MH composite causes more color change than NH composite at all-time intervals. Black plum showed the greatest discoloration in both composites.
Monte Carlo Model Validation of 6MV Beam of OMID, the First Iranian Linear Accelerator
Authors: Abdoli Mohammad Amin , Hassanvand Maryam , Nejatbakhsh Navid
Published: August 2024

Monte Carlo (MC) techniques are regarded as an accurate method to simulate the dose calculation in radiotherapy for many years. The present paper aims to validate the simulated model of the 6-MV beam of OMID linear accelerator (BEHYAAR Company) by EGSnrc codes system and also investigate the effects of initial electron beam parameters (energy, radial full width at half maximum, and mean angular spread) on dose distributions. For this purpose, the comparison between the calculated and measured percentage depth dose (PDD) and lateral dose profiles was done by gamma index (GI) with 1%-1 mm acceptance criteria. MC model validating was done for 3 cm × 3 cm, 5 cm × 5 cm, 8 cm × 8 cm, 10 cm × 10 cm, and 20 cm × 20 cm field sizes. To study the sensitivity of model to beam parameters, the field size was selected as 10 cm × 10 cm and 30 cm × 30 cm. All lateral dose profiles were obtained at 10 cm. Excellent agreement was achieved with a 99.2% GI passing percentage for PDD curves and at least 93.8% GI for lateral dose profiles for investigated field sizes. Our investigation confirmed that the lateral dose profile severely depends on the considered source parameters in this study. PDD only considerably depends on the initial electron beam energy. Therefore, source parameters should not be specified independently. These results indicate that the current model of OMID 6-MV Linac is well established, and the accuracy of the simulation is high enough to be used in various applications.
Immune-related gene characteristics: A new chapter in precision treatment of gastric cancer
Authors: Gao Lei , Lin Qiang
Published: August 2024

Gastric cancer ranks as the sixth most prevalent cancer worldwide. In recent research within the realm of gastric cancer treatment, the identification and application of immune-related genetic features have emerged as groundbreaking advancements. The study by Ma et al , which developed a prognostic model based on 10 genes, categorizes patients into high and low-risk groups to predict their responsiveness to immune checkpoint inhibitor therapy. This research underscores the potential of immune-related genes as biomarkers for personalized treatment, offering insights into tumor mutation burden and immune phenotype scores. We advocate for further validation, understanding of biological mechanisms, and integration of diverse datasets to enhance the model's predictive accuracy and clinical application, marking a significant step towards personalized and precise treatment for gastric cancer.
Navigating the labyrinth of long non-coding RNAs in colorectal cancer: From chemoresistance to autophagy
Authors: Yu Jia-Mei , Sun Chong-Qi , Xu Huan-Huan , Jiang Ya-Li , Jiang Xing-Yu , Ni Si-Qi , Zhao Ting-Yu , Liu Ling-Xiang
Published: August 2024

Long non-coding RNAs (lncRNAs), with transcript lengths exceeding 200 nucleotides and little or no protein-coding capacity, have been found to impact colorectal cancer (CRC) through various biological processes. LncRNA expression can regulate autophagy, which plays dual roles in the initiation and progression of cancers, including CRC. Abnormal expression of lncRNAs is associated with the emergence of chemoresistance. Moreover, it has been confirmed that targeting autophagy through lncRNA regulation could be a viable approach for combating chemoresistance. Two recent studies titled “Human β-defensin-1 affects the mammalian target of rapamycin pathway and autophagy in colon cancer cells through long non-coding RNA TCONS_00014506” and “Upregulated lncRNA PRNT promotes progression and oxaliplatin resistance of colorectal cancer cells by regulating HIPK2 transcription” revealed novel insights into lncRNAs associated with autophagy and oxaliplatin resistance in CRC, respectively. In this editorial, we particularly focus on the regulatory role of lncRNAs in CRC-related autophagy and chemoresistance since the regulation of chemotherapeutic sensitivity by intervening with the lncRNAs involved in the autophagy process has become a promising new approach for cancer treatment.
Analysis of vascular thrombus and clinicopathological factors in prognosis of gastric cancer: A retrospective cohort study
Authors: Chen Guo-Yue , Ren Ping , Gao Zhen , Yang Hao-Ming , Jiao Yan
Published: August 2024

BACKGROUND

Gastric cancer (GC) is one of the most common malignant tumors in the world, and its prognosis is closely related to many factors. In recent years, the incidence of vascular thrombosis in patients with GC has gradually attracted increasing attention, and studies have shown that it may have a significant impact on the survival rate and prognosis of patients. However, the specific mechanism underlying the association between vascular thrombosis and the prognosis of patients with GC remains unclear.

AIM

To analyze the relationships between vascular cancer support and other clinicopathological factors and their influence on the prognosis of patients with GC.

METHODS

This study retrospectively analyzed the clinicopathological data of 621 patients with GC and divided them into a positive group and a negative group according to the presence or absence of a vascular thrombus. The difference in the 5-year cumulative survival rate between the two groups was compared, and the relationships between vascular cancer thrombus and other clinicopathological factors and their influence on the prognosis of patients with GC were analyzed.

RESULTS

Among 621 patients with GC, the incidence of vascular thrombi was 31.7% (197 patients). Binary logistic regression analysis revealed that the degree of tumor differentiation, depth of invasion, and extent of lymph node metastasis were independent influencing factors for the occurrence of vascular thrombi in GC patients (P < 0.01). The trend of the χ 2 test showed that the degree of differentiation, depth of invasion, and extent of lymph node metastasis were linearly correlated with the percentage of vascular thrombi in GC patients (P < 0.01), and the correlation between lymph node metastasis and vascular thrombi was more significant (r = 0.387). Univariate analysis revealed that the 5-year cumulative survival rate of the positive group was significantly lower than that of the negative group (46.7% vs 73.3%, P < 0.01). Multivariate analysis revealed that age, tumor diameter, TNM stage, and vascular thrombus were independent risk factors for the prognosis of GC patients (all P < 0.05). Further stratified analysis revealed that the 5-year cumulative survival rate of stage III GC patients in the thrombolase-positive group was significantly lower than that in the thrombolase-negative group (36.1% vs 51.4%; P < 0.05).

CONCLUSION

Vascular cancer status is an independent risk factor affecting the prognosis of patients with GC. The combination of vascular cancer suppositories and TNM staging can better judge the prognosis of patients with GC and guide more reasonable treatment.
Microvascular structural changes in esophageal squamous cell carcinoma pathology according to intrapapillary capillary loop types under magnifying endoscopy
Authors: Shu Wei-Yang , Shi Yan-Yan , Huang Jiu-Tian , Meng Ling-Mei , Zhang He-Jun , Cui Rong-Li , Li Yuan , Ding Shi-Gang
Published: August 2024

BACKGROUND

The intrapapillary capillary loop (IPCL) characteristics, visualized using magnifying endoscopy, are commonly assessed for preoperative evaluation of the infiltration depth of esophageal squamous cell carcinoma (ESCC). Japan Esophageal Society (JES) classification is the most widely used classification. Microvascular structural changes are evaluated by magnifying endoscopy for the presence or absence of each morphological factor: tortuosity, dilatation, irregular caliber, and different shapes. However, the pathological characteristics of IPCLs have not been thoroughly investigated, especially the microvascular structures corresponding to the deepest parts of the lesions' infiltration.

AIM

To investigate differences in pathological microvascular structures of ESCC, which correspond to the deepest parts of the lesions' infiltration.

METHODS

Patients with ESCC and precancerous lesions diagnosed at Peking University Third Hospital were enrolled between January 2019 and April 2023. Patients first underwent magnified endoscopic examination, followed by endoscopic submucosal dissection or surgical treatment. Pathological images were scanned using a three-dimensional slice scanner, and the pathological structural differences in different types, according to the JES classification, were analyzed using nonparametric tests and t -tests.

RESULTS

The 35 lesions were divided into four groups according to the JES classification: A, B1, B2, and B3. Statistical analyses revealed significant differences (aP < 0.05) in the short and long calibers, area, location, and density between types A and B. Notably, there were no significant differences in these parameters between types B1 and B2 and between types B2 and B3 (P > 0.05). However, significant differences in the short calibers, long calibers, and area of IPCL were observed between types B1 and B3 (aP < 0.05); no significant differences were found in the density or location (P > 0.05).

CONCLUSION

Pathological structures of IPCLs in the deepest infiltrating regions differ among various IPCL types classified by the JES classification under magnifying endoscopy, especially between the types A and B.
Aggressive fibromatosis of the sigmoid colon: A case report
Authors: Yu Pan-Pan , Liu Xin-Chun , Yin Lu , Yin Guang
Published: August 2024

BACKGROUND

Aggressive fibromatosis (AF), also known as desmoid tumor or desmoid-type fibromatosis, is a rare soft tissue neoplasm that can occur in almost any part of the body. Although it is a benign disease, AF is aggressive and infiltrative and has a high recurrence rate after surgery. Common sites for intra-abdominal AF are the small bowel mesentery, retroperitoneum, and pelvis. AF in the colon is extremely rare.

CASE SUMMARY

Here, we report the first case of sigmoid colon AF, which was accidentally discovered in a 27-year-old woman during laparoscopic myomectomy. Computed tomography confirmed a slightly enhanced mass in the sigmoid colon. Subsequent colonoscopy did not reveal a mass in the colonic lumen, but a suspected external compress was found in the sigmoid colon. Surgical disease involving a gastrointestinal stromal tumor was suspected. The patient underwent laparoscopic exploration, and sigmoidectomy with a negative margin was performed to excise the mass. Postoperative immunohistochemistry revealed that the mass was an AF. The patient recovered well and was recurrence-free at the 30-month follow-up without adjuvant therapy.

CONCLUSION

AF should be considered in the differential diagnosis of subepithelial colon masses. Radical resection alone can achieve good outcomes.
Current and future research directions in cellular metabolism of colorectal cancer: A bibliometric analysis
Authors: Jiang Bo-Wen , Zhang Xiu-Hua , Ma Rui , Luan Wen-Yu , Miao Yan-Dong
Published: August 2024

The primary aim of this study was to analyze the evolving trends and key focal points in research on cellular metabolism of colorectal cancer (CRC). Relevant publications on cellular metabolism in CRC were sourced from the Science Citation Index Expanded within the Web of Science Core Collection database. Bibliometric analysis and visualization were conducted using VOSviewer (version 1.6.18) software and CiteSpace 6.1.R6 (64-bit) Basic. A comprehensive compilation of 4722 English-language publications, covering the period from January 1, 1991 to December 31, 2022, was carefully identified and included in the analysis. Among the authors, “Ogino, Shuji” contributed the most publications in this field, while “Giovannucci, E” garnered the highest number of citations. The journal “Cancer Research ” ranked first in both publication volume and citations. Institutionally, “Shanghai Jiao Tong University” emerged as the top contributor in terms of published articles, while “Harvard University” led in citation impact. In country-based analysis, the United States held the top position in both publication output and citations, closely followed by China. The increasing recognition of the significance of cellular metabolism in CRC underscores its potential for novel therapeutic approaches aimed at improving CRC management and prognosis.
Changes in serum levels of pro- and anti-inflammatory cytokines in women with papillomavirus infection before and after therapy”
Authors: Nevezhkina T. А. , Markelova E. V. , Knysh С. V. , Tulupova M. S. , Matyshkina L. S.
Published: August 2024

Papillomavirus infections (PVI) are among the most common sexually transmitted diseases in the young population. A long, sluggish inflammatory process sufficiently worsens adequate preparation for normal pregnancy. Herpesvirus and Chlamydia infections are the most frequent associations with papillomavirus infection. Many authors believe that PVI may cause dysregulation of pro- and anti-inflammatory cytokines revealed in blood serum. Currently, there are no uniform standards for management and treatment of women with papillomavirus infection without pronounced clinical manifestations, in order to prevent morphofunctional disorders of genitourinary system leading to reproductive disorders. However, most authors believe that antiviral and immunomodulatory drugs are the main tool of therapy against expansion of pathogens in the body. The aim of our study was to compare changes in the levels of IL-17, IL-12 p70, IL-12 p40, IL-13 and TGF-p1 in blood serum of women with papillomavirus infection before and after therapy with Inosine pranobex (IP) and Solanum tuberosum (ST).
We conducted a survey of 137 patients with papillomavirus infection treated with drugs containing Inosine pranobex and Solanum tuberosum as active substances. The levels of IL-17, IL-12 p70, IL-12 p40, IL-13, and TGF-p1 in blood serum were determined using specific reagents from RD Diagnostics Inc. (USA).
Changes in pro- and anti-inflammatory cytokines before therapy were as follows: decreased levels were found for IL-12 p70, p40; increased values were revealed for IL-13, IL-17, and TGF-p1. After the courses of therapy, we have registered the following changes in PVI-infected patients treated with synthetic drug Inosine pranobex (IP): the levels of IL-12 p70, IL-12 p40 were increased, along with decrease in IL-13 and TGF-p1. Meanwhile, ST therapy was associated with increase in IL-12 p70, IL-12 p40, and a decrease in IL-13 and TGF-p 1. With IP therapy, patients with combined HPV + HV infection showed an increase in IL-12 p70, IL-12 p40 and a decrease in IL-13, while TGF-p1 did not change. Following ST therapy, these patients exhibited higher IL-12 p70, IL-12 p40, decreased IL-13, whereas TGF-p 1 remained unchanged. In the group of women with HPV + Chlamydia infection, an increase in IL-12 p70, IL-12 p40 and a decrease in IL-13 and TGF-p1 was associated with IP therapy. An increase in IL-12 p70, IL-12 p40 and a decrease in IL-13 and TGF-p 1 were shown after ST therapy. In all groups of patients, IL-17 remained at high levels after therapy without significant differences between the mentioned subgroups. In the groups of patients treated with IP. we have recorded a general normalization of immune disorders.
Immuno-hormonal regulation of tumor proliferation in breast cancer patients
Authors: Glushkov A. N. , Polenok E. G. , Gordeeva L. A. , Antonov A. V. , Bayramov P. V. , Verzhbitskaya N. E. , Kolpinskiy G. I.
Published: August 2024

It is well known that tumor cells proliferation is regulated by sex steroid hormones, estradiol and progesterone (E2 and Pg) in breast cancer patients (BCP). Moreover, specific auto-antibodies to estrogen receptor (ERα) were detected in blood serum of BCP. Their levels positively correlated with the percentage of Ki-67 expressing breast cancer cells. We proposed that antiidiotypic auto-antibodies to E2 and Pg (IgG2-E2 and IgG2-Pg) could act as antibodies against membrane ER and progesterone receptor (PR). Our study aimed for research of IgG2-E2 and IgG2-Pg according to E2 and Pg serum levels in association with Ki-67 positive tumors in BCP. Antiidiotypic antibodies were studied in ER-positive patients with breast cancer (stage I, n = 374, and stage II-IV, n = 379,) using ELISA technique with monoclonal antibodies against E2 and Pg as adsorbed antigens. Blood serum concentrations of E2 and Pg were measured using “ImmunoEA-Estradiol” and “ImmunoEA-Progesterone” test-systems (“Immunotech”, Russia). Tumor Ki-67 was studied by standard immunohistochemical technique at the Kemerovo Oncological Hospital. Higher percentage of Ki-67 positive breast cancer cells (Ki-67 30) was increased in BCP II-IV stages compared with stage I patients (50.7% vs 29.8%, p 0,001). Such increased values were detected for the BCP with low levels of both IgG2-E2 and IgG2-Pg antibodies in the following subgroups: 1) at low serum E2 concentration of ≤ 200 pmol/L (50.9% vs 21.3%, р 0.001); 2) at the E2 exceeding 200 pmol/L (74.2% vs 34.1%, р = 0.003); 3) at the Pg levels under 600 pmol/L (60.6% vs 22.2%, р 0.001); 4) at Pg values exceeding 600 pmol/L (58.5% vs 30.8%, р = 0.02). Similar differences were not revealed between stage II-IV and stage I BCP with low levels of both IgG2-E2 and IgG2-Pg. Corresponding Ki-67 30 indices were as follows: 1) 36.9% vs 22.0% (р = 0.14); 2) 48.4% vs 34.5% (р = 0.08); 3) 34.0% vs 27.7% (р = 0.75). Significant differences were detected in BCP with Pg 600 pmol/L and high IgG2-E2 and IgG2-Pg levels only: 48.1% vs 26.6%, (р = 0.01). Hence, antiidiotypic auto-antibodies to steroid hormones may participate in regulation of tumor proliferation in BCP. Immunoassay of IgG2-E2 and IgG2-Pg may be used for prognosis of tumor proliferation upon breast cancer progression.
The Systematic Review of the Studies Conducted in Turkey on the Topic of Applying 3D Printing in Mathematics Education
Authors: Akın Ayça , Sezgin H. Seda
Published: August 2024

3D printing technology is increasingly widely used in all areas of STEM education. Many researchers emphasize that 3D printing in the context of mathematics education unpacks students' mathematical and design thinking, as well as helps them develop spatial skills, and is a key tool for visualizing mathematical concepts, especially in calculus and geometry. However, when the relevant literature is examined, it is seen that there is no existing systematic review that comprehensively describes and synthesizes the findings in the literature on how 3D printers are applied in mathematics education in the context of studies conducted in Turkey. The purpose of this research is to make a systematic review of the studies conducted between 2015-2023 in Turkey on the topic of applying 3D printing in mathematics education. The results of this study show that qualitative research method is more preferred in the analyzed studies. The predominant dependent variable employed in these investigations is mathematics achievement, with the majority of participants being middle school students. The results of this systematic review indicated that applying 3D printing in mathematics instruction usually helps to improve students’ mathematical literacy, and mathematical skills in the context of studies conducted in Turkey.
„O revoluție care merge pe vârfuri”. De la Întâlnirea Școlilor de Teatru la reorientarea mediului academic după 1990
Authors:   Facultatea de Teatru și Film a Universității Babeș-Bolyai din Cluj, Runcan Miruna
Published: August 2024

After the 80s, an entire decade of crisis and chaos brought by Ceausescu’s politics of reducing the number of students and even the several domains of study in Theatre and Film Schools, the 90s witnessed not only the rebirth of the two traditional Universities in Bucharest and Targu Mureș, but also the emergence of many other new schools, public or private, in Cluj, Iasi, Timisoara, Sibiu, Craiova, Constanta, Galati etc. In this dynamic landscape, in 1993 opens at Targu Mures the European Meeting of Theatre Schools and Academies, as well as The International Festival of Young Professional Theatre in Sibiu. The paper follows the direct and indirect connections between the newborn international festivals dedicated to students and the evolution of academic theatre education in Romania.
Cotidianul „Steaua roșie”, observator al activității Teatrului Studio în perioada comunistă
Authors:   University of Arts Târgu Mureş, Precup Angela
Published: August 2024

The informative publication “Steaua roșie” (“The Red Star”) appeared between 1952 and 1989 in Târgu-Mureș, generating, through its articles, a detailed inventory of the activity within the “Szentgyörgyi István” Theatre Institute, an aspect which transforms the publication into a vital documentary source. The history of the “Studio” Theatre, recorded by the newspaper during its almost four decades of daily appearance, presents a high relevance because, generally speaking, during the communist period, the cultural articles were the only ones managing to limit the ideological invasion in the journalistic pieces, unlike the informative, political or sports articles. Thus, “Red Star” monitored and described in detail all the events, the personalities, the artistic productions and the institutional changes that marked the existence of the “Studio” Theatre, using a different perspective from the strictly professional one offered by the theatrical publications of the period. This day-to-day perspective outlines the ”Studio” Theatre’s profile as an institution that influenced the development of Romanian theatre and theatrical pedagogy, but also as a space of communication and expression for the entire local community.
Kosztolányi Dezső „Édes Anna” című regényének színpadi adaptációja a Marosvásárhelyi Nemzeti Színház Tompa Miklós Társulatának előadásában
Authors:   Eötvös Loránd Tudományegyetem, Budapest, Varga Kinga
Published: August 2024

“Édes Anna”, the novel by the famous Hungarian writer Dezső Kosztolányi, written in 1926, has had twenty-seven stage adaptations throughout the Carpatian Basin in Hungarian. It is about a female servant in the 1920’s in Budapest, who serves at a middle-classed family, and finally she kills her masters. On the 19th of September 2003, the Miklós Tompa Company of the National Theatre of Târgu-Mureș staged their own adaptation of the novel which was directed by László Gali, based on the script by Tibor Solténszky. This adaptation had already been staged in Komárom two years earlier. What were the particularities of the performance in Târgu-Mureș? In my paper I will outline this question in the context of other Édes Anna adaptations and show the peculiarities of this one in light of Hungarian theatre history, that are not sufficiently visible at first sight.
„Dansul sergentului Musgrave” sau primul pas spre un tărâm necunoscut
Authors:   University of Arts Târgu Mureş, Blaga Raluca
Published: August 2024

The paper entitled “Serjeant Musgrave's Dance” or the First Step Into an Unknown Realm aims to bring into the limelight how the only performance signed by Radu Penciulescu at Târgu-Mureș State Theatre, Romanian department (1969) was set for the stage. Our paper will follow the local theatrical environment that absorbs the production (how does it absorb it? is another question that will be addressed). We will also follow the new artistic direction advanced by Radu Penciulescu, a new creative course for which this precise performance represented just the first step. In this endeavour, we’ll try to capture the characteristics of the above-mentioned performance, bearing in mind one of Ion Fiscuteanu’s statements which in an interview, labelled “Serjeant Musgrave's Dance” as a unique theatre experience.
Monument o monstre. La memorialització de Rodoreda com a cos absent/present
Authors: Bru-Dominguez Eva
Published: August 2024

This article draws on Jacques Derrida’s notion of the spectre from Specters of Marx (1993) to examine the process of patrimonialization and simultaneous invisibiliza­tion of certain aspects of Mercè Rodoreda’s work and personal life, focusing on a selec­tion of the commemorative acts organized for the centenary of her birth in 2008. It sit­uates the spectre in relation to Memory and Feminist Studies, paying particular atten­tion to Jo Labanyi’s (2000; 2002) recasting of this concept for the analysis of Spanish cultural production and Angela McRobbie’s (2011) critique to postfeminism’s ghosting of the feminist agenda at the turn of the 21st century. My analysis explores the socio­political and cultural dimension of domestic, natural and visual environments. Firstly, it looks at the ways in which the history of the Senyal Vell, the first house in Romanyà de la Selva where the author lived on her return from exile, has been narrated, arguing that they exemplify the dynamics of selection and appropriation in processes of cultural transmission and commemoration. Secondly, my analysis follows the literary routes drawn around the village and the choice of texts related to the suggested locations, not­ing the repeated omission of her unfinished novel La mort i la primavera. Finally, I draw the study to a conclusion through discussion of the portrayal of Rodoreda in the poster for the play Un dia. Mirall trencat, adapted and directed by Ricard Salvat in 2008, where the author is represented as a witch-like master puppeteer.
Mort i posteritat públiques de Maria Aurèlia Capmany i Montserrat Roig
Authors: Subirana Jaume
Published: August 2024

The treatment of the deaths of Maria Aurèlia Capmany and Montserrat Roig both in the media and in the various commemorative events and initiatives organised in the months and years that followed generate rich and nuanced understanding of the public weight of these two women writers as well as providing insights into approaches to literary afterlives and commemoration in the Catalan cultural scene of the 1990s. This article is based on careful scrutiny of the various texts and discourses produced in memory of two emblematic women writers and public figures who themselves recognised the political and ethical importance of such practices of commemoration. It is followed by reproduction of an article written by Roig herself in memory of Capmany shortly before her own passing.
Les batalles de Roses i de les illes Formigues en els "Gesta Comitum" i en les "Cròniques" de Bernat Desclot i Ramon Muntaner
Authors: Orazi Veronica
Published: August 2024

This paper contains a study of the narration of the naval battles of Roses and the Formigues Islands, transmitted by three fundamental works of Catalan histo­riography, namely Bernat Desclot’s Crònica (1288), the Gesta Comitum (definitive Latin version, early 14th century), and Ramon Muntaner’s Crònica (1325–1328). The collation of the different versions of the events described, crucial moments of the crusade against the Catalan-Aragonese Crown (1285), makes it possible to identify the key aspects of the differences considered irreconcilable by the scholars who have studied them previously, to deepen the theme, shed new light on it and suggest a new interpre­tation.
Das iberische Werk von Otto Denk, Historiker der mittelalterlichen katalanischen Literatur im 19. Jahrhundert
Authors: Friedlein Roger
Published: August 2024

The author of the first German-language history of Catalan literature, Otto Denk (pseud. Otto von Schaching, 1845–1918), has remained an unknown figure in German Catalan studies despite his pioneering historiographical work. The Iberian Peninsula is only one of the many aspects of the Bavarian polygraph’s large oeuvre. His literary and historiographical texts relating to Spain and Catalonia are briefly reviewed in this miscellany on the history of Catalan studies and the main features of his 1893 history of Catalan literature are presented.