bluuebunny/crossref_metadata_2025 huggingface dataset:
In-vitro Evaluation of Antioxidant Activity of Glabridin in Combination with Oroxylin-A
Authors: Vyas Ujwal B , KS Khobragade , PU Vyas
Published: April 2024

There has been a significant increase in interest in the study of free radicals due to shifting dietary and environmental patterns. Our bodies can become exposed to diverse physiochemical circumstances, pathogenic states, or distinct endogenous systems that produce free radicals. Oxidative stress is a condition caused by the body’s exposure to free radicals. We have to give the body an antioxidant source when it can’t handle more oxidative stress. A material that prevents oxidative damage to a target molecule, which is mostly brought on by free radicals, is referred to be an antioxidant. Antioxidants are essential for treating numerous ailments or are used as a supportive treatment for a wide range of disorders brought on by or made worse by oxidative stress. Glabridin and oroxylin-A are well-known active phytoconstituents with high anti-obesity activity. Antioxidants’ hypolipidemic action and potential are very helpful in the treatment of disorders associated with obesity. The current investigation attempts to assess the antioxidant capacity of both oroxylin-A and glaciridin. Ascorbic acid was utilized as the reference antioxidant agent for comparison while evaluating the antioxidant activity. According to the findings, both active ingredients exhibit substantial antioxidant activity more than 65% greater than regular ascorbic acid. When combined with oroxylin-A, glabridin exhibits even greater antioxidant activity more than 80% higher than that of regular ascorbic acid.
Clonidine Enhances Bupivacaine-Lignocaine Supraclavicular Block for Upper Limb Surgery in Tertiary Care Hospital, Salem, Tamil Nadu: A Prospective Study
Authors: Ganesan Arjun , Viveka K , M Rasikapriya , Sabapathy VA
Published: April 2024

Background and Aims: The novel amides bupivacaine and lignocaine are long-acting local anesthetics with distinct blocking properties. The quality of blocking peripheral nerve is enhanced when clonidine is combined with local anesthetics. This investigation aims to evaluate clonidine’s effects on the features of the brachial nerve plexus supraclavicular block induced by ropivacaine. Material and Methods: Two groups of thirty adults each were randomly selected from a total of 60 patients. Group I: About 60 subjects will receive 15 mL each of lignocaine and 0.5% bupivacaine 2% with adrenaline (1:200000) combination. Group II: 30 subjects will receive a mixture of 15 mL each 0.5 and 2% bupivacaine and lignocaine, respectively with adrenaline (1:200000) combined with clonidine (30 mcg). Results: Group II experienced sensorimotor block onset earlier than group I, with sensory block starting at 11.28 ± 1.53 minutes and motor block starting at 9.53 ± 1.32 minutes (19.06 ± 1.7 minutes for blocking sensory nerve and 15.33 ± 2.09 minutes for blocking motor nerve). p < 0.05 determined that both differences were statistically significant. The need for rescue analgesia was significantly higher in group A (p < 0.05). Blocking both sensory and motor nerve blocks occurred more quickly and lasted longer than expected. Hemodynamic measurements, including SPO2 (oxygen saturation), heartbeat, and cardiovascular blood pressure measurements (systolic and diastolic), did not show any discernible variation. Conclusion: The supraclavicular brachial plexus block quality is greatly improved when clonidine is added to ropivacaine as an adjuvant. This results in a quicker onset of anesthesia, increased post-operative pain relief, an extended period of sensory and motor blockage, and none at all at the dose that is given.
Assessment of balance and fear of falling in individuals with acute ankle sprain: A cross-sectional pilot study
Authors: Patil Mandira B. , Holla Shobhalakshmi S. , Ajoy S. M. , Patel Manisha R.
Published: April 2024

Objectives:

The primary objective of this research was to assess balance, pain, and fear of falling (FOF) among individuals with an acute ankle sprain. The secondary objective was to correlate FOF with pain and balance.

Methods:

The research was conducted among individuals with acute ankle sprain —two to three days after removal of two weeks of casting at M S Ramaiah hospitals, Bengaluru. The primary outcome measures were the Short Falls Efficacy Scale-International (Short FES-I) and the star excursion balance test (SEBT), and the secondary outcome measure was the numerical pain rating scale (NPRS). Cutoff points for Short FES-I defined in prior research using receiver operator characteristic plots were used in this study. For Short FES-I, frequencies and percentages were employed. The NPRS and SEBT were measured using means and standard deviations.

Results:

The results showed that among 21 individuals, 76.2% had FOF. Among those with FOF, 56.25% had moderate FOF, and 43.75% had severe FOF. Mean SEBT scores were greater for the uninvolved limb than for the involved limb. Spearman’s Rho test showed that the Short FES-I and NPRS showed no correlation (P = 0.102 > 0.05), and Short FES-I and SEBT showed a significant correlation (P = 0.003 < 0.05).

Conclusion:

The FOF was present in two-thirds of those with acute ankle sprains, and balance impairment was present in individuals with Grade II ankle sprains. Among individuals with FOF, the degree of FOF was moderate to severe. There was a significant negative correlation between FOF and balance, but no correlation was found between FOF and pain.
Victimological aspects of the digital transformation of society
Authors: Pavlova A. A. , Nikolaeva A. A.
Published: April 2024

The article is devoted to the victimological aspects of the digital transformation of society in connection with high criminological risks for users of information and communication technologies, the need for active development of a security mechanism in the cyber environment.
THE PROBLEM OF FUNCTIONAL GENRE IN AZERBAIJANI FOLKLORE STUDIES
Authors:   Institute of Folklore Azerbaijan National Academy of Sciences, Shahla HUSEYNLI
Published: April 2024

In this article the problem of functional genre, which is an important issue in folklore studies, is studied scientifically and theoretically. The formation of a new genre as a result of the process of deriving a genre from a genre has been brought to attention on the basis of specific texts. These genres are called functional genres and it has been considered on the basis of which specifics functionalize the genres such as “bayati”, “gerayli”, “goshma”, “temsil” and fairy tales. Thus, it was initially noted that the genre of “bayati” (quatrain) is not a specific genre, like many other genres, but, in fact, a literary formula. Because many genres are formed on the basis of the genre “bayati”. Among them are quatrains, lullabies, folk songs, ceremonial songs, elegy and other folklore genres are studied in the article and brought to the attention, due to this functionality, even before it was also considered that it was called a literary kind by A. Abid. In particular, it has been observed that the genres created on the basis of “bayati” are widely included in the ceremonial folklore and from the genres of “bayati” forms created in this direction such as wishes, lullabies, Novruz songs, beliefs, occasions, religious holidays, laments, etc. have been looked through. As a functional genre “garayli” like the genre “bayati” has been put forward as a new problem in theoretical and methodological research and garayli, folk songs and important parts of epics, which appeared on the basis of the genre garayli can serve as an example of it as the main genre component. In the article the genre “goshma” is also studied as a functional genre. So, on the basis of this genre “goshma”, “tajnis”, the verse part of epics, “ustadname”, “vujudname”, “gifilbend”, “baghlama” and other genres were formed. Fables have also been brought to the attention as a functional genre, such as representation derived from this genre, allegorical narrative, examples that arise in written and oral literature, etc. can be examples for it. At the same time the representation is manifested both in fairy tales and the fairy tale itself has spawned many genres from itself. The genres of fairy tales, garavelli, anecdotes, jokes and other genres have been reviewed. The theoretical problem proposed in the study is rich in important innovations for the scientific community.
On the formation of vocabulary and the organization of a dictionary entry in the dictionary of the Olonkho language
Authors:   Institute for Humanitarian Research and Problems of Indigenous Peoples of the North, Liya ROBBEK
Published: April 2024

The article presents the result of the procedure for resolving the issue of forming dictionary vocables, as well as organizing a dictionary entry in the dictionary of the language of the Yakut heroic epic Olonkho, proclaimed by UNESCO in 2005 as a masterpiece of the oral and intangible cultural heritage of humanity. The question was one of the rather complex problems in the theoretical development of a dictionary of the Olonkho language. The high degree of formulaicity of the language of the Yakut epic, the originality of the stylistics of the epic narrative and the characteristic features of the language of the Turkic peoples generated a complex of original properties of the Olonkho language, which determined the problematic character of lexicographic works. However, when developing the macro- and microstructure of dictionaries of the language of folklore, an unconventional solution to the problem is allowed, and therefore the work proposes a special structure of a dictionary entry, as well as methods for forming non-standard forms of dictionary vocables. To achieve the goal, we analyzed the functional and semantic features of the lexeme aghys ʻeightʼ in the olonkho text Nurgun Bootur the Swift by K. G. Orosin (1947). As a result of the analysis, the following points were clarified and determined: 1. it was decided to present stable verbal complexes of the Olonkho language (i. e. epic formulas, formulaic constructions, constructions of a formulaic nature), phraseological units, single lexemes and epic periods as vocabulary vocables. The main factors that served as support for making such a decision were the distinctive feature of the Turkic languages – the law of synharmonism, as well as the diffuse nature of the meaning of folk expressions, which requires an integrated approach to the compilation of dictionary definitions, including in the design of the lemma part of the dictionary. The basic principles of the structure of dictionary entries in the Olonkho language dictionary are indicated: the order of presentation of units of lexicographic description, the order of presentation of stable verbal complexes, principles of presentation of material, features of presentation of illustrative material. In developing the described principles, we relied on individual aspects of the theoretical positions expressed in the works of our predecessors, specializing in the field of Russian lingua-folkloristics, Russian folklore lexicography, in Turkic studies, as well as the result of a comprehensive analysis of materials from the K. G. Orosin’s olonkho text of Nurgun Bootur the Swift. In the course of further lexicographical work, it will obviously be possible to make minor adjustments, since the language material of the Yakut epic is extremely diverse. However, the result obtained in this article, in this aspect, will definitely form the basis of lexicography.
La production de la sémiosis. Une mise au point théorique
Authors: Badir Sémir
Published: April 2024

L’appréhension des arts du faire suppose que les objets d’analyse soient considérés selon un registre plus large et plus diversifié que ne les prend la sémiotique classique. Cet élargissement ne va pas toutefois sans poser un certain nombre de problèmes théoriques. Il faut d’abord s’assurer que la sémiotique possède les moyens conceptuels nécessaires pour y procéder. Il faut ensuite s’enquérir des conditions dans lesquelles l’élargissement envisagé est compatible aux états antérieurs de l’analyse. Il faut enfin s’inquiéter des obstacles rencontrés dans l’analyse d’objets aussi globaux que les pratiques culturelles. La présente étude mène cet examen d’un point de vue fidèle à l’enseignement théorique de Hjelmslev. Partant de l’hypothèse que les arts du faire relèvent du plan de l’expression, elle enquête sur les problèmes théoriques évoqués en discutant les tenants d’une synthèse récente proposée par J. Fontanille en vue de l’établissement d’une sémiotique des cultures.
Faire avec le faire communicationnel
Authors: Jeanneret Yves
Published: April 2024

En dépit de la formule "pragmatique", qui tend à replier le signifier sur le faire, la question de la pratique signifiante est extrêmement complexe. L’étude s'emploie à décrire la façon dont cette question est mobilisée, en sciences de la communication, à propos des pratiques médiatiques courantes. L’invocation des pratiques suscite dans cette discipline une stigmatisation de la sémiotique, dont on pourra comprendre qu'elle marque des questions pertinentes, tout en remuant l’illusion d'une communication presque sans le sens (CPSS). Ce qui conduira à discuter la fausse évidence de la notion de "trace", centrale dans cette querelle, à partir des acquis de la recherche sur l’écriture. C'est sur le terrain de l'écriture, modifiée par la métamorphose contemporaine des médias, que pourront être  discutés quelques-uns des efforts actuels pour intégrer une problématique des pratiques dans la description des dispositifs et des textes, à partir des notions de prétention (intervention dans le processus de communication), préfiguration (écriture anticipée des pratiques) et prédilection (mobilisation d’une histoire des formes).
Politique des formes
Authors: Blanc Nathalie , Lolive Jacques
Published: April 2024

La proposition que nous développons ici part d’un double constat : la prise en considération de critères esthétiques, notamment paysagers dans l’action publique et les mobilisations associatives ; l’importance du sentiment esthétique dans la relation à l’environnement. La politique des formes est une expérimentation politique qui vise à promouvoir une conception sensible de l’environnement exprimant un engagement corporel imaginatif et participatif avec la nature. Elle s’enracine dans l’expérience des habitants qui révèle la force et la richesse des attaches qui les relient à leurs milieux de vie. Elle tente d’introduire le jugement esthétique comme un critère démocratique, non expert dans les débats publics. Elle utilise ainsi les formes d’énonciation et de représentation commune (paysage, ambiance, récit) comme des outils d’appréhension de ce qui nous lie à l’environnement et comme des ressorts d’action collective selon des modalités partagées.
Histopathological Changes in Oral Submucous Fibrosis: Updated Review
Authors:   PhD Scholar, Department of Oral Medicine and Radiology, Saveetha Dental College and Hospitals, India, RP Santosh , G Maragathavalli ,   Department of Oral Medicine and Radiology, Saveetha Dental College and Hospitals, India, DNSV Ramesh ,   Department of Oral Medicine and Radiology, AMES Dental College and Hospital, India, K Tejaswi ,   Department of Oral Medicine and Radiology, SVS Institute of Dental Sciences Mahbubnagar, India, S Ankita ,   Department of Oral Medicine and Radiology, New Horizon Dental College and Research Institute, India, MK Alam ,   Department of Orthodontics, College of Dentistry, Jouf University, Kingdom of Saudi Arabia
Published: April 2024

Oral submucous fibrosis is a collagen metabolic condition characterised by excessive collagen formation and reduced collagen breakdown. According to the studies, in addition to increased collagen build-up, there was also an increase in the level of muscle injury. The muscle change might be a symptom of the disease, with atrophy occurring as a result of the muscles’ reduced functional activity caused by fibrosis, or it could be a necessary aspect of the disease’s progression. As a result, histological alterations in OSMF patients will aid in future disease treatment interventions. The objective of the review is to consolidate the various histopathological changes seen in oral submucous fibrosis reported in literature. Various electronic databases like Google Scholar, EMBASE, PubMed, SCOPUS, and Web of Science were searched for articles published until March 2022. Keywords, oral submucous fibrosis, histology, pathology, dysplasia, atrophy were used to search the data base.
Past and Present Progress in the Management of Oral Submucous Fibrosis
Authors:   PhD Scholar, Department of Oral Medicine and Radiology, Saveetha Dental College and Hospitals, India, RP Santosh , G Maragathavalli ,   Department of Oral Medicine and Radiology, Saveetha Dental College and Hospitals, India, DNSV Ramesh ,   Department of Oral Medicine and Radiology, AMES Dental College and Hospital, India, K Tejaswi ,   Department of Oral Medicine and Radiology, SVS Institute of Dental Sciences Mahbubnagar, India, KS Reddy ,   Department of Public Health Dentistry, Navodaya Dental College and Hospital, India, MK Alam ,   Department of Orthodontics, Jouf University, Kingdom of Saudi Arabia
Published: April 2024

As the prevalence of oral submucous fibrosis and its associated morbidity rises, a complete evaluation is needed to examine the efficacy of current and rapidly developed treatment methods, as well as to propose strategies for future notable research. Several studies regarding different treatment modalities have been carried out previously. Hence, this review was undertaken to consolidate existing oral submucous fibrosis therapeutic strategies, update the literature with recent clinical data, and add insight into the field. Various electronic databases like Google Scholar, EMBASE, PubMed, SCOPUS, and Web of Science were searched for articles published until March 2022. Keywords, oral submucous fibrosis, management, medicinal interventions, surgical interventions were used to search the data base.
The Unwonted Veil: A Pediatric Case of a Dermatologic Complication Following a COVID-19 Infection
Authors:   School of Medicine, Texas Tech University Health Sciences Center, USA, Meltan Shakira , Alam Nimat ,   School of Medicine, Texas Tech University Health Sciences Center, USA
Published: April 2024

One week after contracting COVID-19, an 8-year-old African American girl developed a rash covering her face and parts of her arm. This rash resolved after four weeks after treatment with Pimecrolimus cream and barrier repair cream. While no unique exanthem is associated with COVID-19, it has been linked to various cutaneous symptoms. As a result, healthcare providers must be aware of this potential link while examining their patients and be prepared to give counseling to help patients cope with any psychological stress connected with these symptoms.
Cone-Bean Computed Tomography and Light Microscopic Examination of Human Extracted Molars - An in Vitro Study
Authors:   Department of Conservative Dentistry, Faculty of Dental Medicine, Medical University - Sofia, Bulgaria, E Gyulbenkiyan , R Borisov ,   Assistant Professor in Department of Imaging and Oral Diagnostic, Faculty of Dental Medicine, Medical University - Sofia, Bulgaria, R Vasileva ,   Department of Conservative Dentistry, Faculty of Dental Medicine, Medical University - Sofia, Bulgaria, A Gusiyska ,   Department of Conservative Dentistry, Faculty of Dental Medicine, Medical University - Sofia, Bulgaria
Published: April 2024

Introduction: For appropriate root canal therapy, understanding the anatomical and morphological aspects of the endodontic area is critical. Therefore, the study and analysis of images is an important step in the assessment and current clinical treatment of endodontic problems. Furthermore, microscopic-assisted endodontic therapy, particularly for multirooted teeth, is becoming more common in contemporary endodontic clinical practice. The aim of this in vitro study was to examine the distinct types of isthmuses using a light microscope and Cone-Beam Computed Tomography (CBCT). Method: Fifty-five extracted human molars were used for this study. CBCT was used to realize the study. After the CBCT analysis, all teeth were inspected under a light microscope, and the results were compared with those of the CBCT examination. Results: The results from the CBCT at the coronary third of the root canals were as follows: Types I, II, III, IV, and V isthmuses were found in 50.9%, 16.4%, 1.8%, 7.3%, and 23.6% of all samples, respectively. For the middle third, we found Types I, II, III, IV, and V isthmuses in 40.0%, 23.6%, 1.8%, 16.4%, and 18.2% of the samples, respectively. For the apical third, we found Types I, II, III, IV, and V isthmuses in 60.0%, 29.1%, 5.5%, 1.8%, and 3.6% of all samples, respectively. The results obtained from the microscopic examination were similar to those from the CBCT study. There is no confirmed statistically significant difference between the examination methods (p = 0.07). Conclusion: Three-dimensional examinations have a significant role among the methods for diagnosing and detecting an isthmus in the complex root canal system, especially in the apical part.
Aspirin-NHS Ester Mediated Acetylation of Lysine Residues in β-Conglycinin: Implications for Cancer Research in NF-κB
Authors: Schlecht Syon , Gunderson Emily , Aguilar Takara
Published: April 2024

Post-translational modifications (PTMs) represent a dynamic and intricate layer of cellular regulation that significantly contributes to the diversification of protein functions (1). Among these modifications, lysine acetylation stands out as a crucial regulatory mechanism that modulates protein activities, subcellular localization, and interactions (2). This study focuses on expanding the role of lysine acetylation, a significant post-translational modification, within the nuclear factor-kappa B (NF-κB) transcription factor complex. NF-κB plays a crucial role in inflammation, immune responses, and cell survival, making it a pertinent target for cancer research (3). Dysregulation of NF-κB is implicated in various pathological conditions, emphasizing the need to explore lysine acetylation within this context. To perform the acetylation, we would aempt to use a common medication, Aspirin. Aspirin, or acetylsalicylic acid, is a widely studied non-steroidal anti-inflammatory drug (NSAID) that has been extensively used for its anti-inflammatory, analgesic, and antipyretic effects. In addition, the presence of an acetyl group on Aspirin results in a versatile molecule that can acetylate various proteins. (4). We synthesized Aspirin NHS ester (Aspirin-NHS) to capitalize on this versatility in acetylating biomolecules. This tailored approach allows for the selective targeting of lysine residues within proteins, offering a specific tool to examine the functional consequences of lysine acetylation within the NF-κB complex. For this study, a model protein system was used. We selected β-Conglycinin, a soy protein, that offers a pragmatic platform for investigating lysine acetylation within the NF-κB complex. β-Conglycinin is rich in lysine residues, similar to NF-κB, making it homologous to this line of inquiry (5). We can examine the theoretical considerations of lysine acetylation with practical experimental observations, providing a comprehensive understanding of the regulatory dynamics within the NF-κB complex. This research contributes not only to the expanding toolkit for precise protein acetylation modulation but also enhances our understanding of NF-κB's regulatory dynamics in the context of cancer, establishing a bridge between chemical synthesis and biological investigation.
Una revisión sistemática de literatura sobre implementaciones de sistemas de control de tráfico
Authors: Wong Leon Eduardo Rodrigo , Coral Ygnacio Marco Antonio
Published: April 2024

La congestión vehicular es una problemática que se manifiesta frecuentemente en ciudades con alta población y puede deberse a diversos factores, como la incorrecta planificación civil o el transporte público deficiente. Esto provoca un incremento en los accidentes de tránsito, la contaminación del aire, la pérdida de combustible y el descontento ciudadano. Por ello, se considera importante la implementación de sistemas de control de tráfico que genere fluidez en el tránsito vehicular y reduzca los tiempos de viaje. Este trabajo desarrolla una revisión sistemática de la literatura con el propósito de identificar los métodos, algoritmos y modelos más eficientes para la construcción de un sistema de control de tráfico. Los resultados identifican tres métodos y tres algoritmos considerados muy eficientes para el desarrollo de estos sistemas, de los cuales se resaltan el filtro bayesiano y las redes neuronales convolucionales. También se demuestra que You Only Look Once, conocido como YOLO, es el modelo de procesamiento de imagen más eficiente para estas implementaciones.
Isolated metastasis to the scalp in occult breast cancer: a clinical case
Authors: Ognerubov Nikolai A. , Sergeev Ruslan S. , Hizhnyak Aleksej O. , Ognerubova Marina A. , Dzhabrailov Magomed A.
Published: April 2024

Malignancies remain a serious socio-economic health problem worldwide. Among them, breast cancer (BC) in women ranks 1st in the structure and 4th in mortality. Occult breast cancer accounts for 0.1 to 1% of all BC. In this type, metastases to the scalp are extremely rare. This article presents a case of metastatic lesion of the scalp in occult breast cancer. Patient S., 82 years old, presented with a skin tumor in the parietal region, which she noticed about 2 years ago. It has grown recently, with local alopecia and hyperemia around the lesion. A comprehensive examination was performed. Cytology of the punctate showed malignant cells. Mammography and ultrasound showed no specific changes in the breast and lymph nodes. Spiral computed tomography of the chest and abdomen showed no signs of tumor. The lesion was surgically removed. Histological examination revealed adenocarcinoma metastasis. Immunohistochemical examination revealed tumor cells with diffuse and strong expression of estrogen receptors, diffuse and weak expression of progesterone receptors, strong and focal-diffuse expression of cancer embryonic antigen (CEA), and epithelial membrane antigen (EMA). The proliferative activity index of Ki-67 was less than 20%, Her2-neu 0. Considering the morphology and immunohistochemical data, the lesion was a metastasis of breast cancer with a luminal type A molecular biological variant. Skeletal bone scintigraphy revealed no metastatic lesions. The patient was diagnosed with an occult type of breast cancer, stage IV cTxN0M1, with metastasis to the scalp. Hormone therapy with aromatase inhibitors was administered. There were no signs of recurrence during the follow-up for 6 months. Isolated scalp metastasis in occult breast cancer is extremely rare. Practitioners should consider this type of distant metastasis of malignancies in differential diagnosis.
Benefits and limitations of breastfeeding for mothers
with malignant tumors
Authors: Ladodo Olga B. , Iurova Mariia V. , Khokhlova Svetlana V. , Rodionov Valerii V. , Sheshko Elena L. , Zubkov Viktor V. , Makieva Mziya I. , Chutkova Dar’ia A. , Akhapkina Elena S. , Degtyarev Dmitriy N.
Published: April 2024

In the modern world breastfeeding (BF) is considered as a significant factor in reducing the risk of developing malignant tumors of the mammary gland and ovaries. However, the problem of maintenance or refusing BF in malignant neoplasms (malignant neoplasms) still remains open. In recent years, there has been a steady increase in breast cancer (BC), especially in developed countries, with more than 10% of all breast malignancies (BC) diagnosed in women under 40 years of age. The presented article highlights aspects of maintaining lactation in different periods of the relevance of BF in relation to the timing of manifestation of cancer, and also presents data from the multicenter study POSITIVE (Pregnancy Outcome and Safety of Interrupting Therapy for women with endocrine responsIVE breast cancer) on the possibilities of implementing reproductive function and BF in women receiving therapy for hormone-receptor positive (HR+) BC stages I–III. BF with cancer detected in the postpartum period depends on the treatment of the underlying disease. In patients undergoing surgical treatment, BF is not contraindicated, but it is not always technically possible. During chemotherapy, BF is not recommended. When carrying out radiotherapy, it is possible to undergo BF using a healthy mammary gland. There is currently no evidence to suggest that BF woman diagnosed with cancer may have any negative effects. In general, it has been shown that preserving and maintaining lactation in women with a history of cancer is safe for both mother and child.
Efficacy and safety of alpelisib in patients with HR+HER2-negative metastatic breast cancer in real clinical practice: Results of a single-center observational retrospective study
Authors: Sultanbaev Alexander V. , Kolyadina Irina V. , Menshikov Konstantin V. , Musin Shamil I. , Nasretdinov Ainur F. , Sultanbaeva Nadezda I. , Rakhimov Radmir R. , Lipatov Danila O. , Menshikova Irina A. , Izmailov Adel A. , Lipatova Elena E.
Published: April 2024

Background. The combination of alpelisib with fulvestrant is the optimal targeted endocrine therapy for patients with hormone-positive (HR+) HER2-negative (HER2-) metastatic breast cancer (mBC) with mutations in the PIK3CA gene. This regimen has been shown to be highly effective in large phase II and III studies. However, randomized clinical trials cannot fully cover all possible clinical populations of pre-treated patients. Therefore, the real-world study of the efficacy and safety of the alpelisib + fulvestrant is warranted.
Aim. A retrospective analysis of the real-world efficacy and safety of alpelisib in patients with pre-treated luminal HER2- mBC.
Materials and methods. The study included 33 patients diagnosed with HR+ HER- mBC who received alpelisib in combination with fulvestrant in routine practice from 2020 to 2023. Twelve (36.4%) patients had a mutation in exon 9 of the PIK3CA gene, and 21 (63.6%) patients had a mutation in exon 20. Alpelisib was administered to pre-treated patients in different therapy lines: the median number of mBC treatment lines before alpelisib was 5 (1–8), 1 patient received alpelisib in line 1, 4 in line 2, 6 in line 3, 5 in line 4, 8 in line 5, 1 in line 6, 7 in line 7, and 1 in line 8. Patients with luminal B-type BC accounted for 72.7% (n=24). The ECOG status of 0, 1, and 2 points had 9.1%, 75.7%, and 15.2% of patients, respectively.
Results. The median overall survival was 14.0±2.5 months (95% confidence interval 9–18.9), and the median progression-free survival was 6.0±2.7 months (95% confidence interval 0.7–11.3). The prognostic factor was an interruption of drug therapy for any reason, which increased the risk of mortality. The adverse event profile was consistent with data from previous randomized trials.
Conclusion. The outcomes of therapy with alpelisib and fulvestrant show the effectiveness of this regimen in real-world settings in patients with HR+ HER2- advanced BC with a somatic mutation in the PIK3CA gene.
In – Silico Biological Evaluation of Anticancer Drugs - SWISS ADME
Authors: ND Nizamuddin , D Roopa , Alla Pramodini , Shaik Afshin Shams , P Vamshi Kumar Achari , Kapu Sudhakar Reddy
Published: April 2024

The aim of the present work is to prepare anti-cancer drugs through In – Silico Biological Evaluation using SWISS ADME. The new Swiss ADME web tool, which includes in-house expert methods like the BOILED-Egg, Ilogp, and Bioavailability Radar, provides free access to a pool of quick yet reliable predictive models for physicochemical properties, pharmacokinetics, drug-likeness, and medicinal chemistry friendliness. It is developed to predict various pharmacodynamics and pharmacokinetics properties of small molecules, helping researchers in the drug discovery and development process. Researchers can use this tool to assess the potential success of a drug in terms of its ADME. Swiss ADME offers predictive model for various pharmacokinetic properties such as solubility, lipophilicity, and bioavailability this helps researchers assess how a drug candidate will be absorbed, distributed, metabolized, and excreted in the body.
DIGITAL MARKETING STRATEGIES TO INCREASE BRAND AWARENESS
Authors: da Hil , Gusti Girang Permata , lia Yu
Published: April 2024

This research aims to understand the influence of digital marketing on consumer behavior and increase brand awareness in the context of modern business. The research method used is a quantitative descriptive analysis using secondary data from the 2021 E-Commerce Survey conducted by the Indonesia Central Statistics Agency (BPS). The research results show that around 63.52 percent of e-commerce business actors have used internet services for digital marketing, with the benefits of reaching a wider market and marketing cost-effectiveness. However, there are still challenges related to the lack of training in digital marketing. The use of the Internet has also helped increase supply chain efficiency in the production process and facilitate internal company communication.
EXPLORING THE MEDIATING EFFECT OF CONSUMERS' BEHAVIORAL INTENTION TO SHOP ONLINE IN THE RELATIONSHIP BETWEEN FACILITATING CONDITIONS AND ONLINE SHOPPING IN DEVELOPING NATIONS EMPIRICAL EVIDENCE FROM UGANDA’S E-COMMERCE SECTOR
Authors: Jannat Namakula Sarah , Al Sammarraie Najeeb Abbas , Mubuke Faisal
Published: April 2024

The study’s focus was to find out the mediating effect of consumers’ behavioral intention to shop online in the relationship between facilitating conditions and online shopping in Uganda’s e-commerce sector. The study adopted the cross-sectional and correlation approaches to realize the objectives of the study. A sample of 385 respondents was considered given the existing total population of online shoppers in Uganda. The collected data was analyzed using SPSS. Correlation results revealed that there exists a strong significant positive relation between facilitating conditions, intentions to shop online and actual online shopping. The mediation results show that the intention to shop online partially mediated the relationship between facilitating conditions and online shopping. In order to ensure sustainable online purchasing in Uganda, e-commerce owners and their management, the government of Uganda and policymakers need to highly consider the facilitating condition as a key enabling factor that influences consumers’ behavioral intentions and actual online shopping. Like any other study, the researchers were limited in monitoring the real behavioral intentions of the consumers to shop online. To the researcher’s observation, this study is positioned as the first of its kind in Uganda to examine the mediating effect of consumers’ behavioral intentions to shop online in the relationship between facilitating conditions and actual online shopping in Uganda’s e-commerce sector.
CUSTOMER BEHAVIOR ANALYSIS THROUGH DATA ANALYTICS IN THE BANGLADESHI RETAIL INDUSTRY
Authors: Aziz Fardin , Al Haque Tausif , Hossain Maria Bentha , Rahman Abdur , Jalal Siam Saleh Ahmed
Published: April 2024

This qualitative study aims to investigate the state of customer behavior analysis in the Bangladeshi retail industry, with a particular focus on the role of data analytics. The research seeks to explore the current practices, challenges, opportunities, and best strategies employed by retailers in understanding and responding to customer behavior. The Bangladeshi retail industry has witnessed substantial growth driven by factors such as economic development, urbanization, and evolving consumer preferences. In this evolving landscape, retailers increasingly rely on data analytics to gain valuable insights into customer behavior, optimize business operations, and enhance customer experiences. Understanding customer behavior is vital for retailers to tailor their strategies to meet the ever-changing needs and preferences of Bangladeshi consumers. This study employs qualitative research methods, including in-depth interviews with key stakeholders in the Bangladeshi retail industry. The sample size comprises 40 participants, and data analysis involves a thematic approach. The study explores the current state of customer behavior analysis, challenges, opportunities, best practices, and strategies related to data analytics within the retail sector. The findings reveal a growing integration of data analytics in customer behavior analysis, with retailers utilizing various data sources such as point-of-sale data, online transactions, and customer surveys. Challenges include data security concerns and the need for skilled data analysts, while opportunities encompass improved customer retention, enhanced personalization, and more effective marketing campaigns. Best practices emphasize fostering a data-driven culture, collaborating with external data analytics experts, and continuous staff training. The study’s insights have implications for the Bangladeshi retail industry, highlighting the transformative potential of data analytics in adapting to evolving customer preferences and remaining competitive. Recommendations include clear objective setting, investment in data security measures, and the pursuit of external expertise when needed.
ADOPTION OF ELECTRONIC PAYMENT MODE AMONG CONSUMERS OF SELECTED MEDIUM ENTERPRISES IN THE THIRD DISTRICT OF LAGUNA
Authors: E. Enverga Alvin , B. Almario Arthur
Published: April 2024

The study was carried out to ascertain the parameters influencing the use of electronic payment mechanisms to selected medium enterprises in Laguna. Descriptive – survey research method was employed in the study. A researcher-made questionnaire was used to collect the data and information needed for this investigation. The study’s participants include 374 consumers of selected medium enterprises who previously used electronic payment methods. Frequency, percentage, mean, Kruskal Wallis t-test, and effect size were the statistical methods employed. According to the findings of the study, the majority of the respondents were young and highly educated. Surprisingly, consumers were enthusiastic about utilising electronic payment methods. Consumers, on the other hand, perceived technological impediments to using electronic payment systems. Furthermore, there is a significant test of difference in perceptions of electronic payment acceptance based on age and educational attainment among medium-sized business consumers in in the third district of Laguna. Similarly, the study discovered that age is a significant factor that determines customers’ perceptions of barriers to adopting electronic payment in terms of technology in the third district of Laguna. Based on the findings, the researcher recommended that medium-sized businesses may conduct additional research, improve the platform’s usefulness and accessibility, and consider the age factor when promoting electronic payment modes in the third district of Laguna.
Disney's Non-Screen Character and Transmedia Story World Building
Authors: 齐 伟 , 王 亦冰
Published: April 2024

近年来,玲娜贝儿及其所隶属的达菲家族的火爆显示了迪士尼建构跨媒体故事世界的新探索。作为大型媒体娱乐集团,迪士尼通过家族化、系列化和互文性的机制,打造了一批与经典银幕形象具有弱关联的非银幕形象,作为其强大品牌价值和经典IP的副文本。这些非银幕形象在参与式文化表达和现实空间的栖身身份方面具有独特优势,扩展和补充了原有故事世界。同时,银幕和非银幕两种形象生产路径不断相互开放和融合,表征了以迪士尼为代表的大型媒体娱乐集团在建构跨媒体故事世界维度的新趋势。
Creating loyalty through relationship marketing in mobile financial service industry: Moderating role of client demographics
Authors: Rajesh Kumar Saha
Published: April 2024

This study seeks to examine how age and gender influence the relationship between trust, satisfaction, commitment, and loyalty in the context of Mobile Financial Services (MFS). Data for this research were acquired from clients of three major MFS providers using systematic random sampling. The paper utilized Partial Least Squares-Based Structural Equation Modelling (PLS-SEM) to assess the reliability and validity of the data and to evaluate the direct impact of the relationship marketing component on loyalty. The PROCESS macro in SPSS was utilized to assess the moderation effect of age and gender on the connection between relationship marketing components and loyalty. The findings indicate a direct correlation between trust, commitment, and loyalty. Furthermore, it is observed that client demographics do not have a moderating effect on these associations. The impact of satisfaction on loyalty is surprisingly not significant, while age differences play a substantial role in the satisfaction to loyalty link. This research uncovers novel insights that have not yet been explored in earlier studies. This research will be beneficial for MFS providers who are aiming to maintain a consistent clientele.
Evolution and recent advances in RF/microwave transistors
Authors: Liou Juin J. , Schwierz Frank
Published: April 2024

Most applications for radio frequency/microwave (thereafter called RF) transistors had been military oriented in the early 1980s. Recently, this has been changed drastically due to the explosive growth of the markets for civil wireless communication systems. This paper gives an overview on the evolution, current status, and future trend of transistors used in RF electronic systems. Important background, development and major milestones leading to modern RF transistors are presented. The concept of heterostructure, a feature frequently used in RF transistors, is discussed. The different transistor types and their figures of merit are then addressed. Finally an outlook of expected future developments and applications of RF transistors is given.
An adaptive hidden Markov model for indoor OFDM based wireless systems
Authors: Verikoukis Christos V.
Published: April 2024

Detailed physical layer simulation of orthogonal frequency division multiplexing (OFDM) systems requires programs that execute too slowly due to long coherence time of the indoor mobile channel. Evaluation of higher layers of such systems is simplified if suitable models for reproduction of channel errors statistics are available. An adaptive hidden Markov model (HMM) for indoor OFDM based systems that accurately reproduces error statistics of the real system with less computational effort than the exact simulation is presented in this paper. The standard HMM methodology has been modified in order to reproduce the periodicity in the error positions of the OFDM systems. The proposed model is validated by comparison of three statistical parameters: number of errors, length of the errors run and length of the error-free intervals in a frame of bits.
Approximate performance analysis of slotted downlink channel in a wireless CDMA system supporting integrated voice and data services
Authors: Świderski Jacek
Published: April 2024

This paper is concerned with the performance analysis of a slotted downlink channel in a wireless CDMA communication system with integrated packet voice and data transmission. The system model consists of mobile terminals (MT) and a single base station (BS). It is assumed that the voice (data) packet error rate (PER) does not exceed 10-2 (10-5). With this requirement the number of simultaneous transmissions over the downlink channel is limited. Therefore, the objective of the call admission control is to restrict the maximum number of CDMA codes available to voice and data traffic. Packets of accepted voice calls are transmitted immediately while accepted data packets are initially buffered at the BS. This station distinguishes between silence and talkspurt periods of voice sources, so that data packets can use their own codes for transmission during silent time slots. Data packets are buffered in queues created separately for each destination. Discrete-time Markov processes are used to model the system operation. Statistical dependence between queues is the main difficulty which arises during the analysis. This dependence leads to serious computational complexity. The aim of this paper is to present an approximate analytical method based on the restricted occupancy urn model which enables to evaluate system performance despite the dependence. Numerical calculations compared with simulation results show excellent agreement for the average system throughput and the blocking probability of data packets for higher system loads. On the other hand, when the average data packet delay is considered, analytical results underestimate simulation and therefore only approximate system performance evaluation is possible.
Boolean feedback functions for full-length nonlinear shift registers
Authors: Janicka-Lipsk Izabela , Stokłos Janusz
Published: April 2024

In the paper a heuristic algorithm for a random generation of feedback functions for Boolean full-length shift register sequences is presented. With the help of the algorithm one can generate n-stage Boolean full-length shift register sequences for (potentially) arbitrary n
Comparison of the barrier height measurements by the Powell method with the φMS measurement results
Authors: Piskorski Krzysztof
Published: April 2024

In this work, we have compared the barrier height measurements carried out using the Powell method with the photoelectric effective contact potential difference (φMS) measurement results. The photoelectric measurements were performed on the samples that were previously applied in the investigation of the influence of stress on the duration of annealing in nitrogen. This paper shows that the results of barrier height measurement using the Powell method differ significantly from the φ(MS) measurement results.
Gas micro-flow-metering with the in-channel Pt resistors
Authors: Łysko Jan M.
Published: April 2024

Standard thermo-conductive gas flow meters have the side-channel integrated with the temperature detector and heater coils, both winded around the tube. This design suffers from a high thermal capacity, reduced sensitivity in the lower limit flow range, high thermal inertia, long response time and necessity to amplify electronically the output signal. The newly designed TCD detector can be applied as a precise gas flow meter. To identify the composition of the unknown gas, the TCD unit requires a connection to the separation column, application of the reference channel and highly stable flow rate regulator. To measure flow rates, the same TCD unit requires only one flow channel application, with active resistors inside it, and a definition of the gas type. In this work principles of the TCD design, technology and flow rate sensitivity tests are presented.
TSSOI as an efficient tool for diagnostics of SOI technology in Institute of Electron Technology
Authors: Barańsk Mateusz , Sapor Maria , Niemiec Halina , Marczewski Jacek , Kucharski Krzysztof , Kucewicz Wojciech , Kociubiński Andrzej , Jaroszewicz Bohdan , Grodner Mirosław , Domański Krzysztof , Tomaszewski Daniel
Published: April 2024

This paper reports a test structure for characterization of a new technology combining a standard CMOS process with pixel detector manufacturing technique. These processes are combined on a single thick-film SOI wafer. Preliminary results of the measurements performed on both MOS SOI transistors and dedicated SOI test structures are described in detail.
Ultra-wideband 3D image processing for improving landmine detection with GPR
Authors: Ligthart Eveline E. , Yarovoy Alexander G. , Roth Friedrich , Ligthart Leo P.
Published: April 2024

This paper describes a new landmine detection algorithm starting from high resolution 3D ground penetrating radar (GPR) images. The algorithm consists of two procedures, object detection and object classification; both strongly depend on the properties of 3D GPR images. The algorithm has been tested on data measured with an ultrawideband (UWB) video impulse radar (VIR) system developed by the International Research Centre for Telecommunications and Radar (IRCTR). It was found that the algorithm is able to detect all landmines (including difficult to detect M14 mines) and classifies almost all landmines correctly with a large reduction in the number of false alarms caused by clutter. It turns out that for clutter removal it is most effective to eliminate detected objects with a small height.