bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of Chitosan versus Natural Aloe Vera on Candida Adherence in Denture Soft Lining Material
Authors: Memon Muhammad Rizwan , Memon Hina , Shoro Mehwish , Bhurgri Humera , Issrani Rakhi , Iqbal Azhar , Khattak Osama , Altassan Mosa , Almabadi Afaf A. , Sultan Sherif El Sayed , Ismail Hussein Abdelfatth , Baig Muhammad Nadeem , Prabhu Namdeo
Published: January 2024

Background. Soft denture lining materials act as a cushion between the denture base and tissues. Alongside having many advantages, its main problem is candida growth due to its rubbery and porous texture. Many interventions have been performed to halt the growth of candida within soft lining materials such as the use of antifungal therapy and strict oral and denture hygiene but there are consequences such as recurrence, drug resistance, and toxicity related to these interventions. Since natural agents such as aloe vera and chitosan have been proven to have antibacterial and antifungal properties with minimum adverse effects, this study aimed to study the effectiveness of chitosan and aloe vera powders incorporated within denture soft lining materials against candida adherence. Methodology. A total of 60 soft-lining material samples were prepared that were equally divided into three groups, viz., group 1 (chitosan incorporation), group 2 (aloe vera incorporation), and group 3 (control). Candida was obtained from the microbiology lab to form a candidal suspension, diluted in 0.9% NaCl to match the McFarland standard bacteriologic solution. Samples were incubated at 37°C for 24 hours in test tubes containing 100 mL of the candidal suspension and 9.9 mL of the previously prepared Sabouraud dextrose agar. Crystal violet stain was used to stain the adhering cells by fixing them with methanol 80%. For each sample, the adhering candida cells were counted on three standard fields by using an inverted light microscope, and the mean of those fields was recorded. Results. The mean value for samples containing aloe vera was 41.15, while the mean values for samples containing chitosan and the control group were 16.05 and 79.1, respectively. Of all the three groups, aloe vera powder had a significant efficacy against candida growth as compared to the chitosan and control groups (P value = 0.001). Conclusion. Both herbal agents were effective against candida growth. In comparison, aloe vera was more effective against candida growth compared to chitosan.
Pooled CRISPR Screening Identifies P-Bodies as Repressors of Cancer Epithelial–Mesenchymal Transition
Authors: Fang Liang , Zhang Li , Wang Mengran , He Yuhao , Yang Jiao , Huang Zengjin , Tan Ying , Fang Ke , Li Jun , Sun Zhiyuan , Li Yanping , Tang Yisen , Liang Weizheng , Cui Huanhuan , Zhu Qionghua , Wu Zhe , Li Yiming , Hu Yuhui , Chen Wei
Published: January 2024

Epithelial–mesenchymal transition (EMT) is a fundamental cellular process frequently hijacked by cancer cells to promote tumor progression, especially metastasis. EMT is orchestrated by a complex molecular network acting at different layers of gene regulation. In addition to transcriptional regulation, posttranscriptional mechanisms may also play a role in EMT. Here, we performed a pooled CRISPR screen analyzing the influence of 1,547 RNA-binding proteins on cell motility in colon cancer cells and identified multiple core components of P-bodies (PB) as negative modulators of cancer cell migration. Further experiments demonstrated that PB depletion by silencing DDX6 or EDC4 could activate hallmarks of EMT thereby enhancing cell migration in vitro as well as metastasis formation in vivo. Integrative multiomics analysis revealed that PBs could repress the translation of the EMT driver gene HMGA2, which contributed to PB-meditated regulation of EMT. This mechanism is conserved in other cancer types. Furthermore, endoplasmic reticulum stress was an intrinsic signal that induced PB disassembly and translational derepression of HMGA2. Taken together, this study has identified a function of PBs in the regulation of EMT in cancer.

Significance:

Systematic investigation of the influence of posttranscriptional regulation on cancer cell motility established a connection between P-body–mediated translational control and EMT, which could be therapeutically exploited to attenuate metastasis formation.
Data from A Key Role for Early Growth Response-1 and Nuclear Factor-κB in Mediating and Maintaining GRO/CXCR2 Proliferative Signaling in Esophageal Cancer
Authors: Wang Bo , Khachigian Levon M. , Esau Luke , Birrer Michael J. , Zhao Xiaohang , Parker M. Iqbal , Hendricks Denver T.
Published: January 2024

Abstract
Although early growth response-1 (EGR-1) has been shown as a key transcription factor in controlling cell growth, proliferation, differentiation, and angiogenesis, its role in the development of esophageal cancer is poorly understood despite the high frequency of this disease in many parts of the world. Here, immunohistochemistry showed that EGR-1 is overexpressed in 80% of esophageal tumor tissues examined. Furthermore, EGR-1 is constitutively expressed in all esophageal cancer cell lines analyzed. Esophageal squamous carcinoma WHCO1 cells stably transfected with EGR-1 short hairpin RNA displayed a 55% reduction in EGR-1 protein levels, 50% reduction in cell proliferation, a 50% reduction in cyclin-dependent kinase 4 levels, and a 2-fold induction in p27Kip1 levels associated with a G2-M cell cycle arrest. EGR-1 knockdown also caused a marked induction in IκBα expression, an effect also observed in GROβ RNA interference-expressing WHCO1 cells, because EGR-1 lies downstream of GRO/CXCR2 signaling. Furthermore, p65 mRNA levels were also reduced in cells treated with either short hairpin RNA EGR-1 or small interfering RNA EGR-1. Immunohistochemical analysis indicated that p65 is elevated in 78% (n = 61) of esophageal tumor sections analyzed. Moreover, nuclear factor-κB inhibition with either sodium salicylate or p65 RNA interference led to a significant reduction in GROα and GROβ expression. These results indicate that EGR-1 and nuclear factor-κB mediate GRO/CXCR2 proliferative signaling in esophageal cancer and may represent potential target molecules for therapeutic intervention.(Mol Cancer Res 2009;7(5):755–64)
Data from Role of the Protein Tyrosine Kinase Syk in Regulating Cell-Cell Adhesion and Motility in Breast Cancer Cells
Authors: Zhang Xiaoying , Shrikhande Ulka , Alicie Bethany M. , Zhou Qing , Geahlen Robert L.
Published: January 2024

Abstract
The expression of the Syk protein tyrosine kinase in breast cancer cells is inversely correlated with invasive growth and metastasis. The expression of Syk inhibits cell motility while supporting the formation of cell clusters by enhancing cell-cell contacts and promoting the redistribution of the adhesion proteins cortactin and vinculin to these contacts. Syk associates physically with cortactin and catalyzes its phosphorylation on tyrosine. The clustering of integrins leads to the phosphorylation of Syk and of numerous cellular proteins in a manner dependent on the activity of the kinase and on the presence of tyrosine 342 located in the linker B region. The ability of Syk to participate in integrin-mediated protein tyrosine phosphorylation correlates well with its ability to inhibit cell motility. (Mol Cancer Res 2009;7(5):634–44)
Supplementary Figure 7 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
Authors: Taylor Martin S. , Wu Connie , Fridy Peter C. , Zhang Stephanie J. , Senussi Yasmeen , Wolters Justina C. , Cajuso Tatiana , Cheng Wen-Chih , Heaps John D. , Miller Bryant D. , Mori Kei , Cohen Limor , Jiang Hua , Molloy Kelly R. , Chait Brian T. , Goggins Michael G. , Bhan Irun , Franses Joseph W. , Yang Xiaoyu , Taplin Mary-Ellen , Wang Xinan , Christiani David C. , Johnson Bruce E. , Meyerson Matthew , Uppaluri Ravindra , Egloff Ann Marie , Denault Elyssa N. , Spring Laura M. , Wang Tian-Li , Shih Ie-Ming , Fairman Jennifer E. , Jung Euihye , Arora Kshitij S. , Yilmaz Osman H. , Cohen Sonia , Sharova Tatyana , Chi Gary , Norden Bryanna L. , Song Yuhui , Nieman Linda T. , Pappas Leontios , Parikh Aparna R. , Strickland Matthew R. , Corcoran Ryan B. , Mustelin Tomas , Eng George , Yilmaz Ömer H. , Matulonis Ursula A. , Chan Andrew T. , Skates Steven J. , Rueda Bo R. , Drapkin Ronny , Klempner Samuel J. , Deshpande Vikram , Ting David T. , Rout Michael P. , LaCava John , Walt David R. , Burns Kathleen H.
Published: January 2024

Genomics analysis of lung cancer patient cohort.
Supplementary Figure 4 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
Authors: Taylor Martin S. , Wu Connie , Fridy Peter C. , Zhang Stephanie J. , Senussi Yasmeen , Wolters Justina C. , Cajuso Tatiana , Cheng Wen-Chih , Heaps John D. , Miller Bryant D. , Mori Kei , Cohen Limor , Jiang Hua , Molloy Kelly R. , Chait Brian T. , Goggins Michael G. , Bhan Irun , Franses Joseph W. , Yang Xiaoyu , Taplin Mary-Ellen , Wang Xinan , Christiani David C. , Johnson Bruce E. , Meyerson Matthew , Uppaluri Ravindra , Egloff Ann Marie , Denault Elyssa N. , Spring Laura M. , Wang Tian-Li , Shih Ie-Ming , Fairman Jennifer E. , Jung Euihye , Arora Kshitij S. , Yilmaz Osman H. , Cohen Sonia , Sharova Tatyana , Chi Gary , Norden Bryanna L. , Song Yuhui , Nieman Linda T. , Pappas Leontios , Parikh Aparna R. , Strickland Matthew R. , Corcoran Ryan B. , Mustelin Tomas , Eng George , Yilmaz Ömer H. , Matulonis Ursula A. , Chan Andrew T. , Skates Steven J. , Rueda Bo R. , Drapkin Ronny , Klempner Samuel J. , Deshpande Vikram , Ting David T. , Rout Michael P. , LaCava John , Walt David R. , Burns Kathleen H.
Published: January 2024

Circulating ORF1p levels in patients with IPMN
Supplementary Figure 27 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
Authors: Taylor Martin S. , Wu Connie , Fridy Peter C. , Zhang Stephanie J. , Senussi Yasmeen , Wolters Justina C. , Cajuso Tatiana , Cheng Wen-Chih , Heaps John D. , Miller Bryant D. , Mori Kei , Cohen Limor , Jiang Hua , Molloy Kelly R. , Chait Brian T. , Goggins Michael G. , Bhan Irun , Franses Joseph W. , Yang Xiaoyu , Taplin Mary-Ellen , Wang Xinan , Christiani David C. , Johnson Bruce E. , Meyerson Matthew , Uppaluri Ravindra , Egloff Ann Marie , Denault Elyssa N. , Spring Laura M. , Wang Tian-Li , Shih Ie-Ming , Fairman Jennifer E. , Jung Euihye , Arora Kshitij S. , Yilmaz Osman H. , Cohen Sonia , Sharova Tatyana , Chi Gary , Norden Bryanna L. , Song Yuhui , Nieman Linda T. , Pappas Leontios , Parikh Aparna R. , Strickland Matthew R. , Corcoran Ryan B. , Mustelin Tomas , Eng George , Yilmaz Ömer H. , Matulonis Ursula A. , Chan Andrew T. , Skates Steven J. , Rueda Bo R. , Drapkin Ronny , Klempner Samuel J. , Deshpande Vikram , Ting David T. , Rout Michael P. , LaCava John , Walt David R. , Burns Kathleen H.
Published: January 2024

Kaplan-Meier Survival Analysis by ORF1p.
Supplementary Figure 26 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
Authors: Taylor Martin S. , Wu Connie , Fridy Peter C. , Zhang Stephanie J. , Senussi Yasmeen , Wolters Justina C. , Cajuso Tatiana , Cheng Wen-Chih , Heaps John D. , Miller Bryant D. , Mori Kei , Cohen Limor , Jiang Hua , Molloy Kelly R. , Chait Brian T. , Goggins Michael G. , Bhan Irun , Franses Joseph W. , Yang Xiaoyu , Taplin Mary-Ellen , Wang Xinan , Christiani David C. , Johnson Bruce E. , Meyerson Matthew , Uppaluri Ravindra , Egloff Ann Marie , Denault Elyssa N. , Spring Laura M. , Wang Tian-Li , Shih Ie-Ming , Fairman Jennifer E. , Jung Euihye , Arora Kshitij S. , Yilmaz Osman H. , Cohen Sonia , Sharova Tatyana , Chi Gary , Norden Bryanna L. , Song Yuhui , Nieman Linda T. , Pappas Leontios , Parikh Aparna R. , Strickland Matthew R. , Corcoran Ryan B. , Mustelin Tomas , Eng George , Yilmaz Ömer H. , Matulonis Ursula A. , Chan Andrew T. , Skates Steven J. , Rueda Bo R. , Drapkin Ronny , Klempner Samuel J. , Deshpande Vikram , Ting David T. , Rout Michael P. , LaCava John , Walt David R. , Burns Kathleen H.
Published: January 2024

Calibration curve for the large-volume (500 µL) MOSAIC assay.
Supplementary Figure 22 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
Authors: Taylor Martin S. , Wu Connie , Fridy Peter C. , Zhang Stephanie J. , Senussi Yasmeen , Wolters Justina C. , Cajuso Tatiana , Cheng Wen-Chih , Heaps John D. , Miller Bryant D. , Mori Kei , Cohen Limor , Jiang Hua , Molloy Kelly R. , Chait Brian T. , Goggins Michael G. , Bhan Irun , Franses Joseph W. , Yang Xiaoyu , Taplin Mary-Ellen , Wang Xinan , Christiani David C. , Johnson Bruce E. , Meyerson Matthew , Uppaluri Ravindra , Egloff Ann Marie , Denault Elyssa N. , Spring Laura M. , Wang Tian-Li , Shih Ie-Ming , Fairman Jennifer E. , Jung Euihye , Arora Kshitij S. , Yilmaz Osman H. , Cohen Sonia , Sharova Tatyana , Chi Gary , Norden Bryanna L. , Song Yuhui , Nieman Linda T. , Pappas Leontios , Parikh Aparna R. , Strickland Matthew R. , Corcoran Ryan B. , Mustelin Tomas , Eng George , Yilmaz Ömer H. , Matulonis Ursula A. , Chan Andrew T. , Skates Steven J. , Rueda Bo R. , Drapkin Ronny , Klempner Samuel J. , Deshpande Vikram , Ting David T. , Rout Michael P. , LaCava John , Walt David R. , Burns Kathleen H.
Published: January 2024

Circulating ORF1p levels in breast cancer patients.
Supplementary Figure 17 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
Authors: Taylor Martin S. , Wu Connie , Fridy Peter C. , Zhang Stephanie J. , Senussi Yasmeen , Wolters Justina C. , Cajuso Tatiana , Cheng Wen-Chih , Heaps John D. , Miller Bryant D. , Mori Kei , Cohen Limor , Jiang Hua , Molloy Kelly R. , Chait Brian T. , Goggins Michael G. , Bhan Irun , Franses Joseph W. , Yang Xiaoyu , Taplin Mary-Ellen , Wang Xinan , Christiani David C. , Johnson Bruce E. , Meyerson Matthew , Uppaluri Ravindra , Egloff Ann Marie , Denault Elyssa N. , Spring Laura M. , Wang Tian-Li , Shih Ie-Ming , Fairman Jennifer E. , Jung Euihye , Arora Kshitij S. , Yilmaz Osman H. , Cohen Sonia , Sharova Tatyana , Chi Gary , Norden Bryanna L. , Song Yuhui , Nieman Linda T. , Pappas Leontios , Parikh Aparna R. , Strickland Matthew R. , Corcoran Ryan B. , Mustelin Tomas , Eng George , Yilmaz Ömer H. , Matulonis Ursula A. , Chan Andrew T. , Skates Steven J. , Rueda Bo R. , Drapkin Ronny , Klempner Samuel J. , Deshpande Vikram , Ting David T. , Rout Michael P. , LaCava John , Walt David R. , Burns Kathleen H.
Published: January 2024

First round of screening of newly developed monoclonal antibody and dimeric nanobody reagent pairs in patient plasma.
Supplementary Figure 14 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
Authors: Taylor Martin S. , Wu Connie , Fridy Peter C. , Zhang Stephanie J. , Senussi Yasmeen , Wolters Justina C. , Cajuso Tatiana , Cheng Wen-Chih , Heaps John D. , Miller Bryant D. , Mori Kei , Cohen Limor , Jiang Hua , Molloy Kelly R. , Chait Brian T. , Goggins Michael G. , Bhan Irun , Franses Joseph W. , Yang Xiaoyu , Taplin Mary-Ellen , Wang Xinan , Christiani David C. , Johnson Bruce E. , Meyerson Matthew , Uppaluri Ravindra , Egloff Ann Marie , Denault Elyssa N. , Spring Laura M. , Wang Tian-Li , Shih Ie-Ming , Fairman Jennifer E. , Jung Euihye , Arora Kshitij S. , Yilmaz Osman H. , Cohen Sonia , Sharova Tatyana , Chi Gary , Norden Bryanna L. , Song Yuhui , Nieman Linda T. , Pappas Leontios , Parikh Aparna R. , Strickland Matthew R. , Corcoran Ryan B. , Mustelin Tomas , Eng George , Yilmaz Ömer H. , Matulonis Ursula A. , Chan Andrew T. , Skates Steven J. , Rueda Bo R. , Drapkin Ronny , Klempner Samuel J. , Deshpande Vikram , Ting David T. , Rout Michael P. , LaCava John , Walt David R. , Burns Kathleen H.
Published: January 2024

Representative SPR sensorgrams of ORF1 “3rd Gen.” nanobody multimers with “5xCys Tail.
Supplementary Figure 10 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
Authors: Taylor Martin S. , Wu Connie , Fridy Peter C. , Zhang Stephanie J. , Senussi Yasmeen , Wolters Justina C. , Cajuso Tatiana , Cheng Wen-Chih , Heaps John D. , Miller Bryant D. , Mori Kei , Cohen Limor , Jiang Hua , Molloy Kelly R. , Chait Brian T. , Goggins Michael G. , Bhan Irun , Franses Joseph W. , Yang Xiaoyu , Taplin Mary-Ellen , Wang Xinan , Christiani David C. , Johnson Bruce E. , Meyerson Matthew , Uppaluri Ravindra , Egloff Ann Marie , Denault Elyssa N. , Spring Laura M. , Wang Tian-Li , Shih Ie-Ming , Fairman Jennifer E. , Jung Euihye , Arora Kshitij S. , Yilmaz Osman H. , Cohen Sonia , Sharova Tatyana , Chi Gary , Norden Bryanna L. , Song Yuhui , Nieman Linda T. , Pappas Leontios , Parikh Aparna R. , Strickland Matthew R. , Corcoran Ryan B. , Mustelin Tomas , Eng George , Yilmaz Ömer H. , Matulonis Ursula A. , Chan Andrew T. , Skates Steven J. , Rueda Bo R. , Drapkin Ronny , Klempner Samuel J. , Deshpande Vikram , Ting David T. , Rout Michael P. , LaCava John , Walt David R. , Burns Kathleen H.
Published: January 2024

Representative SPR sensorgrams of ORF1 nanobodies.
Supplementary Data 2 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
Authors: Taylor Martin S. , Wu Connie , Fridy Peter C. , Zhang Stephanie J. , Senussi Yasmeen , Wolters Justina C. , Cajuso Tatiana , Cheng Wen-Chih , Heaps John D. , Miller Bryant D. , Mori Kei , Cohen Limor , Jiang Hua , Molloy Kelly R. , Chait Brian T. , Goggins Michael G. , Bhan Irun , Franses Joseph W. , Yang Xiaoyu , Taplin Mary-Ellen , Wang Xinan , Christiani David C. , Johnson Bruce E. , Meyerson Matthew , Uppaluri Ravindra , Egloff Ann Marie , Denault Elyssa N. , Spring Laura M. , Wang Tian-Li , Shih Ie-Ming , Fairman Jennifer E. , Jung Euihye , Arora Kshitij S. , Yilmaz Osman H. , Cohen Sonia , Sharova Tatyana , Chi Gary , Norden Bryanna L. , Song Yuhui , Nieman Linda T. , Pappas Leontios , Parikh Aparna R. , Strickland Matthew R. , Corcoran Ryan B. , Mustelin Tomas , Eng George , Yilmaz Ömer H. , Matulonis Ursula A. , Chan Andrew T. , Skates Steven J. , Rueda Bo R. , Drapkin Ronny , Klempner Samuel J. , Deshpande Vikram , Ting David T. , Rout Michael P. , LaCava John , Walt David R. , Burns Kathleen H.
Published: January 2024

Contains all Tables and Figures in one file
Data from Product Attributes of CAR T-cell Therapy Differentially Associate with Efficacy and Toxicity in Second-line Large B-cell Lymphoma (ZUMA-7)
Authors: Filosto Simone , Vardhanabhuti Saran , Canales Miguel A. , Poiré Xavier , Lekakis Lazaros J. , de Vos Sven , Portell Craig A. , Wang Zixing , To Christina , Schupp Marco , Poddar Soumya , Trinh Tan , Warren Carmen M. , Aguilar Ethan G. , Budka Justin , Cheng Paul , Chou Justin , Bot Adrian , Shen Rhine R. , Westin Jason R.
Published: January 2024

Abstract
Treatment resistance and toxicities remain a risk following chimeric antigen receptor (CAR) T-cell therapy. Herein, we report pharmacokinetics, pharmacodynamics, and product and apheresis attributes associated with outcomes among patients with relapsed/refractory large B-cell lymphoma (LBCL) treated with axicabtagene ciloleucel (axi-cel) in ZUMA-7. Axi-cel peak expansion associated with clinical response and toxicity, but not response durability. In apheresis material and final product, a naive T-cell phenotype (CCR7+CD45RA+) expressing CD27 and CD28 associated with improved response durability, event-free survival, progression-free survival, and a lower number of prior therapies. This phenotype was not associated with high-grade cytokine release syndrome (CRS) or neurologic events. Higher baseline and postinfusion levels of serum inflammatory markers associated with differentiated/effector products, reduced efficacy, and increased CRS and neurologic events, thus suggesting targets for intervention. These data support better outcomes with earlier CAR T-cell intervention and may improve patient care by informing on predictive biomarkers and development of next-generation products.
Significance:
In ZUMA-7, the largest randomized CAR T-cell trial in LBCL, a naive T-cell product phenotype (CCR7+CD45RA+) expressing CD27 and CD28 associated with improved efficacy, decreased toxicity, and a lower number of prior therapies, supporting earlier intervention with CAR T-cell therapy. In addition, targets for improvement of therapeutic index are proposed.

This article is featured in Selected Articles from This Issue, p. 4
Duration and Efficiency of Combined versus Isolated Aerobic Training Interventions in Post-Stroke Cognition: A Systematic Review
Authors: Maeneja Reinaldo , Ferreira Inês Saraiva , Abreu Ana Maria
Published: January 2024

Background: This study aimed to evaluate the effects of physical activity on the cognition of patients with stroke, comparing the effectiveness of using isolated or combined rehabilitation, as well as the duration and intensity of training, to identify the characteristics of optimal training programs for post-stroke cognitive rehabilitation. Methods: For this systematic review, we followed PRISMA guidelines and searched Web of Science, Scopus, PEDRo, SPORTdiscus, PubMed, Trial Registries, and Google Scholar for studies published between 2013 and April 12, 2023. We included randomized controlled trials (RCTs) of interventions that measured the effect of physical activity on cognition in patients with stroke. We restricted our search to reports published in the English language. Evidence from the RCTs was synthesized. The risk of bias was assessed using the Cochrane risk of bias tool. Results: Of the 1,755 records identified, 34 were eligible, and data were available, with mainly low to moderate risk of general bias. The combined rehabilitation training programs proved more efficient when compared with isolated rehabilitation training programs in several cognitive domains. A moderate-intensity, 12-week intervention duration, with three weekly sessions, proved adequate. Discussion: It seems that combined rehabilitation training programs are efficient for patients with stroke as these alter neuroplastic conditions due to synergistic or additional onset of action. Future research should investigate combined rehabilitation training programs, with follow-up, to assess how long the recorded improvements last. The protocol of this study is registered in PROSPERO, number CRD42021248533.
Endoscopic Kyoto and Kimura-Takemoto Classifications Are Comparable in Predicting High-Risk Gastric Precancerous Lesions
Authors: Nguyen Doan Thi Nha , Quach Duc Trong , Le Quang Dinh , Vu Nhu Thi Hanh , Dang Ngoc Le Bich , Le Huy Minh , Le Nhan Quang , Oka Shiro , Tanaka Shinji , Hiyama Toru
Published: January 2024

Introduction: Severe and extensive gastric atrophy, extensive or incomplete gastric intestinal metaplasia, and gastric dysplasia are considered high-risk gastric precancerous lesions (HGPLs). Endoscopic findings based on the endoscopic Kyoto classification (EKC) and the Kimura-Takemoto classification (KTC) have been reported to be significantly associated with HGPLs. This study aimed to compare these two classifications in predicting active Helicobacter pylori (H. pylori) infection and HGPLs. Methods: This is a cross-sectional study conducted on naïve dyspeptic patients who underwent upper gastrointestinal endoscopy at a tertiary hospital. Endoscopic findings were scored according to the EKC and KTC. Mapping biopsies were taken, and H. pylori infection was determined using a locally validated rapid urease test and histology. The performance of EKC was compared with that of KTC using the area under the receiver operating characteristic curve (AUC) in predicting active H. pylori infection and HGPLs. Results: There were 292 patients with a median age of 46 and a male-to-female ratio of 1:1. The rates of active H. pylori infection and HGPLs were 61.3% and 14.0%, respectively. The EKC was better than the KTC in predicting active H. pylori infection (AUC: 0.771 vs. 0.658, respectively; p < 0.001). However, these two classifications had comparable performance in predicting HGPLs (AUC: 0.792 vs. 0.791, respectively; p = 0.956). Conclusion: Compared to EKC, KTC is inferior in predicting active H. pylori infection but has comparable performance in predicting HGPLs.
Hidradenitis Suppurativa Is Associated with Severe Sexual Impairment
Authors: Krajewski Piotr K. , Strobel Alexandra , Schultheis Michael , Staubach Petra , Grabbe Stephan , Hennig Katharina , Matusiak Lukasz , von Stebut Esther , Garcovich Simone , Bayer Hans , Heise Marcus , Kirschner Uwe , Nikolakis Georgios , Szepietowski Jacek C.
Published: January 2024

Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory disorder of the pilosebaceous unit, often affecting and deforming intimate regions. HS is associated with severe pain, pruritus, and constant, purulent, malodorous discharge expected to impair sexual health of patients. Methods: We performed a cross-sectional, multicentric study involving 199 German patients from the health services research project “Epidemiology and Care in Acne inversa (EpiCAi).” The sexual health, HS severity, and quality of life of the studied group were evaluated using a specially designed questionnaire. Results: Regardless of gender, HS has an enormous impact on patients’ sexual health. The patients scored, on average, 28.8 ± 5.3 points on the Relation and Sexuality Scale (RSS). Multiple linear regression revealed that females and patients with Hurley III stage had higher sexual dysfunction (p = 0.012). Sexual dysfunction is associated with pain (β = 0.25), the number of active lesions, the affected areas (β = 0.14), and psychosocial aspects, including low quality of life (β = 0.404), stigmatization (β = 0.411), depression (β = 0.413), and anxiety (β = 0.300). Patients already see a substantial decrease in sexual frequency in the early stages of HS, while functional impairment and fear increase with the severity of the disease. Conclusion: Sexual health and management of its dysfunctions should be part of a holistic approach to HS patients.
Mortality and Autopsy Findings in Patients with Pyoderma Gangrenosum: A Multi-Institutional Series
Authors: Shakshouk Hadir , deCampos-Stairiker Mallory , Kody Shannon , Stenzel Peter , Xia Eric , Mostaghimi Arash , Wu Bicong , Shinohara Michi M. , Marzano Angelo V. , Polly Samantha , Fernandez Anthony P. , Ortega-Loayza Alex G.
Published: January 2024

Introduction: Pyoderma gangrenosum (PG) is a rare ulcerative skin condition with an increased risk of mortality compared to the general population. The causes of this increased risk are not well understood. Misdiagnosis is common in PG, and many studies are limited by the inclusion of misdiagnosed cases. The goal of this study was to review autopsy findings, identify causes of death, and identify factors that may worsen outcomes among deceased patients confirmed to have PG. Methods: Data was retrospectively reviewed from the electronic medical records at five academic hospitals. A search was conducted for deceased patients with a diagnosis of PG who had an autopsy performed between 2010 and 2020. We report a descriptive analysis of 11 patients and their clinical characteristics, causes of death, and autopsy findings. Results: The average age of death was 62.9 years. Seven patients had at least one underlying condition known to be associated with PG including inflammatory bowel disease, inflammatory arthritis, or a hematologic disorder. The most common cause of death was infection (n = 6, 54.5%), followed by pulmonary embolism (n = 3, 27.3%), and myelodysplastic syndrome (n = 2, 18.2%). Six patients (54.5%) were taking systemic steroids at the time of death. Conclusion: The development of PG may shorten life expectancy among those with underlying conditions associated with PG, and common treatments for PG may contribute to the risk of fatal complications. Awareness of the risk of infection, thrombosis, and malignancy among those with PG is necessary for proper management. Further research is needed to explore the relationship between PG and thromboembolism.
Clinical Utilization of Generic Drugs and Biosimilars for Ulcerative Colitis Treatment: Insights from a Nationwide Database Study in Japan
Authors: Moroi Rintaro , Kakuta Yoichi , Nagai Hiroshi , Shimoyama Yusuke , Naito Takeo , Shiga Hisashi , Kinouchi Yoshitaka , Masamune Atsushi
Published: January 2024

Introduction: Limited data exist regarding the prevalence and clinical practice involving generic drugs and biosimilars for treating ulcerative colitis (UC) in Japan. We aimed to clarify the clinical usage of these generic drugs and biosimilars for UC treatment in Japan using a nationwide database. Methods: We collected data from 30,675 UC cases, along with their prescriptions for both generic drugs or biosimilars and their original counterparts, using a medical claim database provided by DeSC Healthcare, Inc. We calculated the prescription and penetration rates of generic drugs and biosimilars and demonstrated the transition of these rates. Additionally, the cumulative retention rates between infliximab originator and biosimilar were compared using the Kaplan-Meier method. Results: The prescription rate of generic mesalazine increased from approximately 10% in 2015 to over 30% in 2021. Although the prescription rate of generic molecular targeting drugs (MTDs) also increased from approximately 0.15% in 2014 to 2.5% in 2021, the increment was lower than that of generic mesalazine. The penetration rates of generic 5-aminosalicylic acid and tacrolimus ranged from over 30% to approximately 50%. Infliximab biosimilar achieved an approximate 20% penetration rate, whereas adalimumab achieved <5%. The cumulative retention rates did not differ between infliximab originator and biosimilar. Conclusions: The penetration rates of generics and biosimilars for UC treatment are relatively low compared with those for treatment in other fields and the goal of the Ministry of Health, Labor, and Welfare. Several countermeasures are necessary for the widespread use of generics and biosimilars, ultimately contributing to cost-effective and sustainable healthcare delivery.
Why Do Real Wages Stagnate in Japan and Korea?
Authors: Chun Hyunbae , Fukao Kyoji , Kwon Hyeog Ug , Park Jungsoo
Published: January 2024

This study investigates the reasons behind the slowdown in real wages for Japan and Korea based on the aggregate and industry-level data for the respective countries. The findings suggest the following. First, both at the aggregate and industry level, there is a significant slowdown in both countries in the post-1995 period regarding labor productivity, which explains the overall slowdown in real wages. Second, the main reason for the gap between the growths in real wages and labor productivity is found to be the changes in the labor's terms of trade, which is defined as the consumer price index to GDP deflator ratio. Thus, the wage–labor productivity gap is not systematically connected to changes in labor income shares. Finally, the fall in the labor's terms of trade may be potentially related to an emphasis on exports and strong technological upgrading toward higher productivity growth products in both countries’ economic development.
Topics in the Haystack: Enhancing Topic Quality through Corpus
Expansion
Authors: Thielmann Anton , Reuter Arik , Seifert Quentin , Bergherr Elisabeth , Säfken Benjamin
Published: January 2024

Extracting and identifying latent topics in large text corpora have gained increasing importance in Natural Language Processing (NLP). Most models, whether probabilistic models similar to Latent Dirichlet Allocation (LDA) or neural topic models, follow the same underlying approach of topic interpretability and topic extraction. We propose a method that incorporates a deeper understanding of both sentence and document themes, and goes beyond simply analyzing word frequencies in the data. Through simple corpus expansion, our model can detect latent topics that may include uncommon words or neologisms, as well as words not present in the documents themselves. Additionally, we propose several new evaluation metrics based on intruder words and similarity measures in the semantic space. We present correlation coefficients with human identification of intruder words and achieve near-human level results at the word-intrusion task. We demonstrate the competitive performance of our method with a large benchmark study, and achieve superior results compared with state-of-the-art topic modeling and document clustering models. The code is available at the following link: https://github.com/AnFreTh/STREAM.
Common Flaws in Running Human Evaluation Experiments in NLP
Authors: Thomson Craig , Reiter Ehud , Belz Anya
Published: January 2024

While conducting a coordinated set of repeat runs of human evaluation experiments in NLP, we discovered flaws in every single experiment we selected for inclusion via a systematic process. In this squib, we describe the types of flaws we discovered, which include coding errors (e.g., loading the wrong system outputs to evaluate), failure to follow standard scientific practice (e.g., ad hoc exclusion of participants and responses), and mistakes in reported numerical results (e.g., reported numbers not matching experimental data). If these problems are widespread, it would have worrying implications for the rigor of NLP evaluation experiments as currently conducted. We discuss what researchers can do to reduce the occurrence of such flaws, including pre-registration, better code development practices, increased testing and piloting, and post-publication addressing of errors.
Notes on Albizia (Leguminosae—Caesalpinioideae—mimosoid clade) in China
Authors: BAI LIN
Published: January 2024

This study clarifies taxonomic issues related to some frequently confused Albizia species in China which were referred as A. calcarea, A. duclouxii, A. garrettii, A. kalkora and A. lebbeck in Flora of China, but which were later reduced to A. garrettii, A. kalkora and A. lebbeck in the Catalogue of Life China. Based on a literature review, herbarium specimen examinations and field observations, six species are now recognised for this group. It is confirmed that the name A. kalkora had long been misapplied to the most widely distributed Albizia species in China. The correct name for this species is A. macrophylla, which was previously treated as a synonym of A. lebbeck. The identity of A. kalkora, which was based on material from Bihar Province, northern India, remains unknown, but a brief summary of its taxonomic history is provided. Albizia henryi and A. duclouxii are resurrected from the synonymy of A. kalkora. Albizia simeonis, which was formerly a synonym of A. kalkora, is here treated a synonym of A. henryi. Albizia calcarea is resurrected from the synonymy of A. garrettii and is newly reported from Guangdong, Guizhou and Hunan Provinces of China, and from northern Vietnam. The close relationship between A. calcarea, A. duclouxii and A. henryi is discussed. Further study of A. duclouxii is needed to better-assess its rank and its relationship to its two close relatives. Lectotypes are designated for A. calcarea, A. garrettii, A. henryi, and A. esquirolii. Former holotype citations are corrected to lectotypes for A. duclouxii and A. simeonis. A key to species, distinctive features, habitat, phenology, distribution and taxonomic notes for each species, and maps showing the distribution of the species that are native to China, together with a comparative table summarising the more important characters of each species are provided. Colour plates for four of the species are provided.
Contribution to Cynoglossum species (Boraginaceae) in Turkey
Authors: SUTORÝ KAREL
Published: January 2024

Three overlooked taxa, all of them with a rather extensive distribution range, from the group of Cynoglossum species of the western part of the Irano-Turanian (I-T) region are discussed. Cynoglossum teheranicum is distributed from Iran through Armenia and Georgia to the northeast of Turkey. The two newly proposed endemic species C. anatolicum is distributed over almost the entire territory of Turkey, while C. longeglochidiatum grows dispersed in a ring of localities flanking the Central Anatolian plateau. All three species belong to the group of hard to distinguish Cynoglossum species commonly classified in Turkey under C. montanum. Their distribution areas are shown on maps and the main characters used for identification are presented and illustrated. Emphasis is put on nutlet characters: length/width ratio, length of glochidia and their arrangement on the nutlet surface.
Religion-making in South Asia: An interstitial perspective
Authors: Singh Nirvikar
Published: January 2024

The study of ‘Hinduism’ in contemporary academia has generated considerable controversy. Many scholars have argued that the idea of a single ancient religion is difficult to substantiate based on the historical record. A common alternative position is that Hinduism is a colonial construct, without well-defined historical antecedents. This paper contributes to a scholarly middle ground, which provides an empirically based yet still contingent analysis of the evolution of ‘Hinduism’, by drawing on evidence from the Sikh tradition. In doing so, it also draws on approaches which interpret Islam as a discursive tradition, subject to contestable representations, shaped by conditions of knowledge and power, as well as by collective aspirations. Sikh attempts at self-definition included distinguishing their tradition from the two larger, pre-existing traditions of Muslims and Hindus in an explicit and self-conscious manner. In doing so, Sikh leaders recognised ‘Hindu’ as a religious category to some degree, well before the colonial period.
Intestinal Translocation of Live Porphyromonas gingivalis Drives Insulin Resistance
Authors: Niu C. , Lv W. , Zhu X. , Dong Z. , Yuan K. , Jin Q. , Zhang P. , Li P. , Mao M. , Dong T. , Chen Z. , Luo J. , Hou L. , Zhang C. , Hao K. , Chen S. , Huang Z.
Published: January 2024

Periodontitis has been emphasized as a risk factor of insulin resistance–related systemic diseases. Accumulating evidence has suggested a possible “oral–gut axis” linking oral infection and extraoral diseases, but it remains unclear whether periodontal pathogens can survive the barriers of the digestive tract and how they play their pathogenic roles. The present study established a periodontitis mouse model through oral ligature plus Porphyromonas gingivalis inoculation and demonstrated that periodontitis aggravated diet-induced obesity and insulin resistance, while also causing P. gingivalis enrichment in the intestine. Metabolic labeling strategy validated that P. gingivalis could translocate to the gastrointestinal tract in a viable state. Oral administration of living P. gingivalis elicited insulin resistance, while administration of pasteurized P. gingivalis had no such effect. Combination analysis of metagenome sequencing and nontargeted metabolomics suggested that the tryptophan metabolism pathway, specifically indole and its derivatives, was involved in the pathogenesis of insulin resistance caused by oral administration of living P. gingivalis. Moreover, liquid chromatography–high-resolution mass spectrometry analysis confirmed that the aryl hydrocarbon receptor (AhR) ligands, mainly indole acetic acid, tryptamine, and indole-3-aldehyde, were reduced in diet-induced obese mice with periodontitis, leading to inactivation of AhR signaling. Supplementation with Ficz (6-formylindolo (3,2-b) carbazole), an AhR agonist, alleviated periodontitis-associated insulin resistance, in which the restoration of gut barrier function might play an important role. Collectively, these findings reveal that the oral–gut translocation of viable P. gingivalis works as a fuel linking periodontitis and insulin resistance, in which reduction of AhR ligands and inactivation of AhR signaling are involved. This study provides novel insight into the role of the oral–gut axis in the pathogenesis of periodontitis-associated comorbidities.
End of Cycle or Continuity of Bolivia’s Democratic-Cultural Revolution?
Authors: González Paredes Jorge Hugo
Published: January 2024

Despite running for a fourth term as president and winning in the first round in October 2019’s presidential elections, Evo Morales was violently overthrown in a civilian, police, and military coup. This event provided rationales for the leftist detractors of the MAS government to float the end-of-cycle theory with regard to Bolivia. Various perspectives were involved in this debate: the approach of the postextractivist/postdevelopmentalist left, the critique of the autonomist left, the approach of the doctrinaire/revolutionary left, and the perspective of the progressive left, which is sympathetic to the Morales government. Because of a lack of understanding of the reconfiguration under way of international dependency relations under neoliberalism, the end-of-cycle theory distorts reality, specifically with regard to Bolivian politics.

A pesar de postularse para un cuarto mandato como presidente y ganar en la primera vuelta de las elecciones presidenciales de octubre de 2019, Evo Morales fue derrocado violentamente en un golpe de estado civil, policial y militar. Este evento sirvió de base para que los detractores izquierdistas del gobierno del MAS plantearan la teoría del fin de ciclo con respecto a Bolivia. En este debate se involucraron varias perspectivas: el enfoque de la izquierda posextractivista/posdesarrollista, la crítica de la izquierda autonomista, el enfoque de la izquierda doctrinaria/revolucionaria y la perspectiva de la izquierda progresista, que de hecho simpatiza con el gobierno de Morales. Debido a la falta de comprensión en torno a la reconfiguración en curso de las relaciones de dependencia internacional bajo el neoliberalismo, la teoría del fin de ciclo distorsiona la realidad, particularmente en lo que respecta a la política boliviana.
Can Cryptocurrencies Provide Better Diversification Benefits? Evidence from the Indian Stock Market
Authors: Jana Susovon , Nandi Ankita , Sahu Tarak Nath
Published: January 2024

Cryptocurrency has recently emerged as a financial asset among policymakers, investors and academics as a new alternative asset in the financial landscape. This research intends to empirically evaluate the safe haven, diversification and hedging potentials of digital currencies against the Indian equity market during different time frames. Four cryptocurrencies (Bitcoin, Ethereum, Binance Coin and Ripple) and Nifty 50 index data have been collected on a daily basis, from 26 July 2017 to 31 August 2023, for this purpose. Using wavelet-based methods, the study has discovered higher volatility in Nifty 50 and cryptocurrency prices during the crisis and stronger co-movement between pairs of equities and cryptocurrencies. Furthermore, the study finds that, under normal economic conditions, cryptocurrency can hedge the Indian stock market over short-term, medium-term and long-term investment horizons. However, investing in cryptocurrencies in the Indian stock portfolio for the short term does not give any safe haven or diversification advantages during times of economic crisis. Finally, we anticipate that the findings of our study will provide valuable insights into the potential usage of cryptocurrencies in the Indian stock market, both in stable and turbulent economic conditions.

JEL Codes: G01, G41, N2, P34
Book review: Sara Rizvi Jafree, Social Policy for Women in Pakistan
Authors: Iqbal Nasir
Published: January 2024

Sara Rizvi Jafree, Social Policy for Women in Pakistan (Cham: Palgrave Macmillan, 2023), xxv + 382 pp.
A critical review on deformation-induced transformation kinetics of austenitic stainless steels
Authors: Jain Ashish , Varshney Abhinav
Published: January 2024

Deformation-induced austenite to martensite transformation is an important phenomenon during the deformation of metastable fully austenitic transformation induced plasticity (TRIP) steels. The kinetics of austenite to martensite transformation influence the deformation behaviour of austenitic stainless steels but is often neglected by the materials community. In this paper, after an initial discussion on thermodynamics and mechanism, the importance of deformation-induced transformation kinetics is briefly outlined and the influence of various parameters like grain size, deformation temperature, strain rate, stress state and prior austenite deformation on the transformation kinetics is critically assessed. Variation of transformation kinetics with various parameters has been identified and justified. These variations could act as a ready reference for designing austenitic stainless steels with the desired set of mechanical properties and deformation behaviour. Further in this paper, selected models that can predict the transformation kinetics are reviewed and compared. In the end, research fronts related to transformation kinetics that can be further explored have been identified.
The microstructure and mechanical properties of Mg-Sn-based alloy processed by differential-thermal equal channel angular pressing
Authors: Guo Feifei , Li Yaqin , Zhou Tianshui , Zhang GuoFeng , Hu Shiwen , Liu Dexue
Published: January 2024

Numerous studies of equal channel angular pressing (ECAP) considered the sample and mould temperatures as a whole, ignoring their different control effects during ECAP deformation. In this paper, the microstructure and mechanical properties of Mg-Sn-Zn-Zr (TZK) alloys were investigated after ECAP deformation at different mould and sample temperatures. The results revealed that higher mould temperatures controlled the actual deformation temperatures and lower sample temperatures prevented grain growth during preheating. After ECAP deformation at mould temperature of 300 °C and sample temperature of room temperature, the alloy consisted of abundant dynamical recrystallisation grains, with an elongation of 30% and a strength of 251.49 MPa. This study would provide a novel idea for the optimisation of the ECAP process.
Laser powder bed fusion of crack-free 6061Al alloy using nano-sized TiO2 modified powders
Authors: Yuan Chao , Ding Rengen , Hou Xiaodong , Guo Qiujuan , Gao Xuexu
Published: January 2024

Growth of coarse columnar grains during solidification easily leads to hot cracking during laser powder bed fusion (LPBF) of Al alloys. This work offers an alternative route to inhibit the formation of coarse columnar grains during LPBF process. The crack-free 6061Al alloy with a refined microstructure was obtained using nano-sized TiO2 modified feedstock powders. After HIPPing, a nearly defect-free sample was obtained with a fracture elongation of 19.5 ± 0.14%. After artificially peak ageing treatment, the TiO2 modified 6061Al alloy fabricated by LPBF exhibits a tensile strength of 336.1 ± 3.5 MPa and the fracture elongation is still 8.1 ± 0.92%. It is believed that the approaches used in this work are also effective for other LPBF fabrication of low-printability Al alloys.
Microstructure evolution of in-situ synthesised (TiB + TiC) particulate reinforced titanium matrix composites casting
Authors: Bong-Jae Choi
Published: January 2024

This research article focuses on the microstructure evolution and crystallisation sequence of particulate-reinforced titanium matrix composites (TMCs) prepared through the investment casting process. Boron carbide (B4C) was added to the titanium melts using vacuum induction melting, resulting in an in-situ reaction, 5Ti + B4C = 4TiB + TiC, that produced 5, 10 and 20 vol.-% (TiB + TiC) reinforcements. The results showed that the size and distribution of the in-situ reinforcements varied with the B4C size and content. Additionally, the presence of carbon element in graphite crucible affected the crystallisation sequence of TiB and TiC, leading to different morphologies and sizes. The study also investigated the interaction between the TMCs and mould materials, demonstrating the feasibility of achieving alpha-case controlled TMC castings.