bluuebunny/crossref_metadata_2025 huggingface dataset:
Essential Infantile Esotropia: A Course of Treatment From Our Experience
Authors: Pensiero Stefano , Diplotti Laura , Presotto Marianna , Ronfani Luca , Barbi Egidio
Published: July 2021

Background: Essential infantile esotropia (EIE) is the most common type of childhood esotropia. Although its classical approach is surgical, less invasive techniques have been proposed as an adjunct or alternative to traditional surgery. Among them, chemodenervation with botulinum toxin (BT) has been investigated, showing variable and sometimes conflicting results.

Objectives: To compare the outcomes of bilateral BT injection and traditional surgery in a pediatric population with EIE in order to optimize and standardize the therapeutic approach. Other purposes are to evaluate whether early intervention may prevent the onset of vertical ocular deviation (which is part of the clinical picture of EIE) and/or influence the development of fine stereopsis, and also to assess changes in refractive status over time among the enrolled population.

Methods: A retrospective consecutive cohort study was conducted in 86 children aged 0–48 months who underwent correction of EIE. The primary intervention in naïve subjects was either bilateral BT injection (36 subjects, “BT group”) or strabismus surgery (50 subjects, “surgery group”).

Results: Overall, BT chemodenervation (one or two injections) was effective in 13 (36.1%) subjects. With regard to residual deviation angle, the outcomes at least 5 years after the last intervention were overlapping in children receiving initial treatment with either injection or surgery; however, the success rate of primary intervention in the surgery group was higher, and the average number of interventions necessary to achieve orthotropia was smaller. Both early treatment with chemodenervation and surgery at a later age were not found to prevent the onset of vertical ocular deviation, whereas, surprisingly, the percentage of subjects developing fine stereopsis was higher in the surgery group. Finally, with regard to the change in refractive status over time, most of the subjects increased their initial hyperopia, whereas 10% became myopic.

Conclusions: Our data suggest that a single bilateral BT injection by age 2 years should be considered as the first-line treatment of EIE without vertical component; whereas, traditional surgery should be considered as the first-line treatment for all other cases and in subjects unresponsive to primary single BT injection.
Metformin Alleviates Hepatic Steatosis and Insulin Resistance in a Mouse Model of High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease by Promoting Transcription Factor EB-Dependent Autophagy
Authors: Zhang Dan , Ma Yicheng , Liu Jianjun , Deng Yi , Zhou Bo , Wen Yu , Li Mingke , Wen Daiyan , Ying Yunyan , Luo Sufeng , Shi Chunjing , Pu Guangyu , Miao Yinglei , Zou Chenggang , Chen Yuanli , Ma Lanqing
Published: July 2021

Nonalcoholic fatty liver disease (NAFLD) results from an abnormal accumulation of lipids within hepatocytes, and is commonly associated with obesity, insulin resistance, and hyperlipidemia. Metformin is commonly used to treat type 2 diabetes mellitus and, in recent years, it was found to play a potential role in the amelioration of NAFLD. However, the mechanisms underlying the protective effect of metformin against NAFLD remain largely unknown. Transcription factor EB (TFEB) is a master transcriptional regulator of lysosomal biogenesis and autophagy and, when activated, is effective against disorders of lipid metabolism. However, the role of TFEB in hepatic steatosis is not well understood. In this report, we demonstrate that the activity of TFEB is reduced in the liver of mice fed a high-fat diet. Metformin treatment significantly reverses the activity of TFEB, and the protective effect of metformin against hepatic steatosis and insulin resistance is dependent on TFEB. We show that metformin-induced autophagy is regulated by TFEB, and our findings reveal that TFEB acts as a mediator, linking metformin with autophagy to reverse NAFLD, and highlight that TFEB may be a promising molecular target for the treatment of NAFLD.
Cytokine Release Syndrome Is an Independent Risk Factor Associated With Platelet Transfusion Refractoriness After CAR-T Therapy for Relapsed/Refractory Acute Lymphoblastic Leukemia
Authors: Liu Yadan , Liang Bin , Liu Yan , Wei Guoqing , Wu Wenjun , Yang Luxin , Yang Li , Huang He , Xie Jue , Hu Yongxian
Published: July 2021

Background: Chimeric antigen receptor T cell (CAR-T) therapy is successful in improving treatment outcomes for relapsed/refractory acute lymphoblastic leukemia (R/R ALL). However, toxicities associated with CAR-T therapy are being increasingly identified. Pancytopenia is one of the most common complications after CAR-T therapy, and platelet transfusions are an essential part of its supportive care.

Study Design and Methods: This study aimed to assess the effectiveness of platelet transfusions for R/R ALL patients at our single center and identify associated risk factors. Overall, 44 R/R ALL patients were enrolled in this study, of whom 26 received CAR-T therapy and 18 received salvage chemotherapy.

Result: Patients in the CAR-T group had a higher incidence of platelet transfusion refractoriness (PTR) (15/26, 57.7%) than those in the chemotherapy group (3/18, 16.7%) (p = 0.007). For patients receiving CAR-T therapy, multivariate analysis showed that the grade of cytokine release syndrome (CRS) was the only independent risk factor associated with PTR (p = 0.007). Moreover, higher peak serum IL-6 and IFN-γ levels suggested a higher risk of PTR (p = 0.024 and 0.009, respectively). Patients with PTR received more platelet infusion doses than those without PTR (p = 0.0426). Patients with PTR had more grade 3–4 bleeding events than those without PTR (21.4 vs. 0%, p = 0.230), and the cumulative incidence of grade 3–4 bleeding event was different (p = 0.023).

Conclusion: We found for the first time that PTR is associated with the CRS grade. Improved knowledge on the mechanisms of PTR after CAR-T therapy is needed to design a rational therapeutic strategy that aims to improve the efficiency of transfusions.
Molecular Characterization and Elucidation of Pathways to Identify Novel Therapeutic Targets in Pulmonary Arterial Hypertension
Authors: Yao Xiaoting , Jing Tian , Wang Tianxing , Gu Chenxin , Chen Xi , Chen Fengqiang , Feng Hao , Zhao Huiying , Chen Dekun , Ma Wentao
Published: July 2021

Background: Pulmonary arterial hypertension (PAH) is a life-threatening chronic cardiopulmonary disease. However, there are limited studies reflecting the available biomarkers from separate gene expression profiles in PAH. This study explored two microarray datasets by an integrative analysis to estimate the molecular signatures in PAH.

Methods: Two microarray datasets (GSE53408 and GSE113439) were exploited to compare lung tissue transcriptomes of patients and controls with PAH and to estimate differentially expressed genes (DEGs). According to common DEGs of datasets, gene and protein overrepresentation analyses, protein–protein interactions (PPIs), DEG–transcription factor (TF) interactions, DEG–microRNA (miRNA) interactions, drug–target protein interactions, and protein subcellular localizations were conducted in this study.

Results: We obtained 38 common DEGs for these two datasets. Integration of the genome transcriptome datasets with biomolecular interactions revealed hub genes (HSP90AA1, ANGPT2, HSPD1, HSPH1, TTN, SPP1, SMC4, EEA1, and DKC1), TFs (FOXC1, FOXL1, GATA2, YY1, and SRF), and miRNAs (hsa-mir-17-5p, hsa-mir-26b-5p, hsa-mir-122-5p, hsa-mir-20a-5p, and hsa-mir-106b-5p). Protein–drug interactions indicated that two compounds, namely, nedocromil and SNX-5422, affect the identification of PAH candidate biomolecules. Moreover, the molecular signatures were mostly localized in the extracellular and nuclear areas.

Conclusions: In conclusion, several lung tissue-derived molecular signatures, highlighted in this study, might serve as novel evidence for elucidating the essential mechanisms of PAH. The potential drugs associated with these molecules could thus contribute to the development of diagnostic and therapeutic strategies to ameliorate PAH.
Occurrence and Prevention of Delayed Autonomous Selfing in Salvia umbratica (Lamiaceae)
Authors: Xiao Han-Wen , Huang Yan-Bo , Chang Yu-Hang , Chen Yun , Abbott Richard J. , Wei Yu-Kun , Ma Yong-Peng
Published: July 2021

Delayed autonomous selfing (DAS) provides reproductive assurance under conditions of pollinator and/or pollen-limitation. Few plant species have been investigated to determine if DAS is terminated when a flower is sufficiently pollinated by a pollen vector, thereby saving plant resources for other purposes. We examined this possibility in bumblebee-pollinated Salvia umbratica. We first showed that DAS resulting in high fruit set (100%) and seed set (>80%) per flower occurred in the absence of insect pollinators by means of style recurvature and was completed in 94% of flowers 72 h after they opened. In contrast, in flowers pollinated immediately after opening, DAS was prevented by corollas dropping away before styles recurve toward the upper thecae. We next showed that hand-pollination of flowers immediately after they opened resulted in high fruit set (100%) and seed set (>80%) when 5–10 pollen grains or more were deposited on their stigmas, whereas fruit set and seed set were reduced to 45.00 and 22.50%, respectively, when pollen loads were reduced to 1–3 pollen grains. Finally, we showed that on average single pollinator visits deposited 26 pollen grains on stigmas of flowers that had just opened, which is more than enough to ensure high fruit and seed set. Our results indicate that flower longevity is highly correlated with the pollinator environment and female fitness of S. umbratica, with extended flower longevity allowing DAS to occur being advantageous when pollinators are absent, while reduced floral longevity and prevention of DAS being favored when flowers are pollinated by pollinators. Thus, flower longevity in S. umbratica varies so as to optimize reproductive output and resource efforts, and is dependent on the availability and effectiveness of pollinators to pollinate flowers.
Major QTLs and Potential Candidate Genes for Heat Stress Tolerance Identified in Chickpea (Cicer arietinum L.)
Authors: Jha Uday Chand , Nayyar Harsh , Palakurthi Ramesh , Jha Rintu , Valluri Vinod , Bajaj Prasad , Chitikineni Annapurna , Singh Narendra P. , Varshney Rajeev K. , Thudi Mahendar
Published: July 2021

In the context of climate change, heat stress during the reproductive stages of chickpea (Cicer arietinum L.) leads to significant yield losses. In order to identify the genomic regions responsible for heat stress tolerance, a recombinant inbred line population derived from DCP 92-3 (heat sensitive) and ICCV 92944 (heat tolerant) was genotyped using the genotyping-by-sequencing approach and evaluated for two consecutive years (2017 and 2018) under normal and late sown or heat stress environments. A high-density genetic map comprising 788 single-nucleotide polymorphism markers spanning 1,125 cM was constructed. Using composite interval mapping, a total of 77 QTLs (37 major and 40 minor) were identified for 12 of 13 traits. A genomic region on CaLG07 harbors quantitative trait loci (QTLs) explaining >30% phenotypic variation for days to pod initiation, 100 seed weight, and for nitrogen balance index explaining >10% PVE. In addition, we also reported for the first time major QTLs for proxy traits (physiological traits such as chlorophyll content, nitrogen balance index, normalized difference vegetative index, and cell membrane stability). Furthermore, 32 candidate genes in the QTL regions that encode the heat shock protein genes, heat shock transcription factors, are involved in flowering time regulation as well as pollen-specific genes. The major QTLs reported in this study, after validation, may be useful in molecular breeding for developing heat-tolerant superior lines or varieties.
Endophytic Colonization by the Entomopathogenic Fungus Beauveria Bassiana Affects Plant Volatile Emissions in the Presence or Absence of Chewing and Sap-Sucking Insects
Authors: González-Mas Natalia , Gutiérrez-Sánchez Fernando , Sánchez-Ortiz Araceli , Grandi Luca , Turlings Ted C. J. , Manuel Muñoz-Redondo José , Moreno-Rojas José Manuel , Quesada-Moraga Enrique
Published: July 2021

Entomopathogenic fungi are gaining acceptance in Integrated Pest Management (IPM) systems as effective and environmental safety biological control agents to protect a great variety of crops against pest insects. Many of these insect-pathogenic fungi can establish themselves as endophytes and thereby may induce the plant immune system. The activation of plant defenses by the fungal endophytic colonization can have a direct impact on herbivores and plant pathogens. An integral component of many plant defense responses is also the release of volatile organic compounds, which may serve as an indirect defense by attracting the natural enemies of herbivores. Here we investigated the effect of endophytic colonization by the entomopathogenic fungus Beauveria bassiana on the volatile emission by melon and cotton plants, either unharmed or after being damaged by sap-sucking aphids or leaf chewing caterpillars. We found that when the plants are colonized by B. bassiana they emit a different blend of volatile compounds compared to uncolonized control plants. Some of the emitted compounds have been reported previously to be released in response to herbivory and have been implicated in natural enemy attraction. Several of the compounds are also known to have antimicrobial properties. Therefore, endophytic colonization by B. bassiana might help to not only direct control insect pests but also increase the resistance of plants against agronomically important pests and phytopathogens.
ExoS/ChvI Two-Component Signal-Transduction System Activated in the Absence of Bacterial Phosphatidylcholine
Authors: Geiger Otto , Sohlenkamp Christian , Vera-Cruz Diana , Medeot Daniela B. , Martínez-Aguilar Lourdes , Sahonero-Canavesi Diana X. , Weidner Stefan , Pühler Alfred , López-Lara Isabel M.
Published: July 2021

Sinorhizobium meliloti contains the negatively charged phosphatidylglycerol and cardiolipin as well as the zwitterionic phosphatidylethanolamine (PE) and phosphatidylcholine (PC) as major membrane phospholipids. In previous studies we had isolated S. meliloti mutants that lack PE or PC. Although mutants deficient in PE are able to form nitrogen-fixing nodules on alfalfa host plants, mutants lacking PC cannot sustain development of any nodules on host roots. Transcript profiles of mutants unable to form PE or PC are distinct; they differ from each other and they are different from the wild type profile. For example, a PC-deficient mutant of S. meliloti shows an increase of transcripts that encode enzymes required for succinoglycan biosynthesis and a decrease of transcripts required for flagellum formation. Indeed, a PC-deficient mutant is unable to swim and overproduces succinoglycan. Some suppressor mutants, that regain swimming and form normal levels of succinoglycan, are altered in the ExoS sensor. Our findings suggest that the lack of PC in the sinorhizobial membrane activates the ExoS/ChvI two-component regulatory system. ExoS/ChvI constitute a molecular switch in S. meliloti for changing from a free-living to a symbiotic life style. The periplasmic repressor protein ExoR controls ExoS/ChvI function and it is thought that proteolytic ExoR degradation would relieve repression of ExoS/ChvI thereby switching on this system. However, as ExoR levels are similar in wild type, PC-deficient mutant and suppressor mutants, we propose that lack of PC in the bacterial membrane provokes directly a conformational change of the ExoS sensor and thereby activation of the ExoS/ChvI two-component system.
The Influence of Focus Marking on Pronoun Resolution in Dialogue Context
Authors: Blything Liam P. , Järvikivi Juhani , Toth Abigail G. , Arnhold Anja
Published: July 2021

Using visual world eye-tracking, we examined whether adults (N= 58) and children (N= 37; 3;1–6;3) use linguistic focussing devices to help resolve ambiguous pronouns. Participants listened to English dialogues about potential referents of an ambiguous pronoun he. Four conditions provided prosodic focus marking to the grammatical subject or to the object, which were either additionally it-clefted or not. A reference condition focussed neither the subject nor object. Adult online data revealed that linguistic focussing via prosodic marking enhanced subject preference, and overrode it in the case of object focus, regardless of the presence of clefts. Children’s processing was also influenced by prosodic marking; however, their performance across conditions showed some differences from adults, as well as a complex interaction with both their memory and language skills. Offline interpretations showed no effects of focus in either group, suggesting that while multiple cues are processed, subjecthood and first mention dominate the final interpretation in cases of conflict.
How Do Spelling, Handwriting Speed, and Handwriting Quality Develop During Primary School? Cross-Classified Growth Curve Analysis of Children's Writing Development
Authors: Gosse Claire , Parmentier Michael , Van Reybroeck Marie
Published: July 2021

Aim: Longitudinal studies are rare in the field of writing research, and little is known about the concurrent development of the two transcription skills: spelling and handwriting. This study was designed to provide a comprehensive picture of the development and the longitudinal relations between spelling, handwriting speed, and handwriting quality at the word level.

Method: Over a period of 3 years (coh1: Grades 2–4; coh2: Grades 3–5), 117 French-speaking children were assessed on a single-word dictation task. At each testing time, measures of spelling accuracy, handwriting speed, and handwriting quality were collected on 40 words. Words varied in both orthographic and graphic complexity, making it possible to investigate the influence of these levels of complexity on transcription abilities.

Results: Linear growth analyses using cross-classified Bayesian structural equation modeling (CC-BSEM) revealed that spelling and speed continued to improve until Grade 5, while handwriting quality reached an early plateau in Grade 2. In the younger cohort, graphic complexity had a significant influence on the pace of development of handwriting speed and on spelling and handwriting quality performance in Grade 2. In the older cohort, a positive relation between spelling and speed and a negative relation between handwriting speed and handwriting quality were found, indicating that fast handwriting is associated with high spelling ability and that fast handwriting is detrimental to handwriting quality. By providing a better understanding of writing development, this study yields innovative findings not only regarding the development of transcription skills but also regarding how spelling, handwriting speed, and handwriting quality can influence each other's performance throughout primary school.
Investigating the Youth Sports Development Pathway Within a South African Context
Authors: van den Berg Liandi , Jonck Petronella , Surujlal Jhalukpreya
Published: July 2021

The past two decades witnessed increased participation in professional as well as amateur sport, giving impetus to concomitant amplified interest in long-term athlete development (LTAD). LTAD has been described as the structured and progressive growth of an athlete through different stages of development resulting in some athletes achieving elite sport status. Furthermore, the interest in athletic career development from a holistic perspective has contributed to management approaches underscoring sustainable talent development and participation in sport. The current study investigated youth sports development pathways through both models of development within a South African context. A descriptive quantitative cross-sectional design was used to generate a convenient sample of athletes (N= 267). The Talent Development Environment Questionnaire (TDEQ) was administered, which in previous studies produced acceptable psychometric properties. Principal factor analysis, confirmatory factor analysis, Monte Carlo parallel simulation, MANOVA, and hierarchical regression were performed to analyze the data. The TDEQ was validated for the South African context and was found to measure four components, namelysupportive and challenging environment,development fundamentals,support networks, andlong-term development. Respondents in the various developmental categories of novice, advanced and elite student-athletes were not statistically significantly influenced by any of the four factors. Controlling for the talent developmental phase, the model proposed did not statistically significantly predict the development pathway of youth athletes. The results provide evidence with some practical significance as supportive and challenging environment and long-term development focus reported a small effect. Further research is warranted to develop a more suitable measuring instrument to measure the talent development pathway within the investigated athlete environment.
The Influence of Cognitive Load on Distractor-Response Bindings
Authors: Singh Tarini , Schubert Torsten
Published: July 2021

Binding theories postulate an integration of stimulus and response features into temporary episodic traces or event files. In general, in the visual binding literature, attention is considered to be necessary to feature binding, and a higher cognitive load can lead to worse performance. On the other hand, in stimulus-response binding theories, central attention is not regarded as necessary in binding effects. A possible discrepancy between the visual feature binding findings and the findings in stimulus-response binding studies could lie in the amount of central load implemented, whereas another discrepancy was related to a specific type of process that was manipulated. In the present study, load was manipulated in three levels, such as no load, low load, and high load, and the binding effects were tested under each condition. Load was manipulated by using a secondary task, which was to be carried out simultaneously with the primary task. Additionally, the influence of targeting different working memory processes (maintenance and updating) was examined by varying the time point of the presentation of the secondary task. The results indicate that, under high load, binding effects are observed if memory contents are merely maintained, but not observed when memory contents are actively updated.
Depression in the Mirror: Depression Severity and Its Link to Negative Judgments of Symptoms
Authors: Visco-Comandini Federica , Gragnani Andrea , Giacomantonio Mauro , Romano Giuseppe , Petrucci Manuel , Mancini Francesco
Published: July 2021

Background and Objectives: Depressive states represent a normal and physiological response to the experience of loss. However, it is possible to identify some elements that allow distinguishing physiological depressive states from pathological ones. Over the years, research has confirmed that a stable tendency to negative self-evaluation is a transdiagnostic factor that triggers and amplifies dysfunctional emotional reactivity, thus contributing to the shift from normal to pathological reaction. In this sense, the secondary problem, or meta-emotional problem, referring to the negative evaluation of one's depressive state and the consequent dysfunctional attempts to solve it, seems to play an important role. The aim of the present study is to investigate how dysfunctional beliefs and the evaluations of depressive symptoms (meta-emotional problems) are related to depression severity.

Methods: We asked to a community sample to focus on the depressive symptoms they regard as most distressful and evaluate them through specific questionnaires. One-hundred and eighty nine participants were asked to complete a set of questionnaires: (1) the Meta-Emotional Problem Questionnaire; (2) the Center for Epidemiologic Studies Depression Scale; (3) the Beck Depression Inventory; (4) the Dysfunctional Attitude Scale-24 in order to investigate the relation between dysfunctional beliefs, meta-emotional problems, and depressive symptoms severity.

Results: Our results show that higher levels of depression are associated both to more pervasive dysfunctional attitudes and increased evaluation of meta-emotional problem. In addition, we conduct a regression analysis to disentangle the impact of the two different measures of depressive symptoms (i.e., BDI-II and CES-D) with two explanatory variables (dysfunctional attitudes and meta-emotional problem). Results show that meta-emotional problem remains a significant and robust predictor of the severity of depressive symptomatology, while dysfunctional beliefs has a rather weak and non-significant relation with the criterion. In other words, meta-emotional problem consistently explains the higher variance of depressive symptoms than dysfunctional beliefs. In conclusion, our study shows a clear link between meta-emotional problem and depression severity. This is relevant for clinical practice, as it highlights the importance of specifically targeting beliefs about the depressive condition in cognitive-behavioral treatment of depression, since they represent crucial factors maintaining depressive symptomatologies.
Postinfectious COVID-19 Catatonia: A Report of Two Cases
Authors: Torrico Tyler , Kiong Timothy , D'Assumpcao Carlos , Aisueni Uyi , Jaber Fouad , Sabetian Katayoun , Molla Mohammed , Kuran Rasha , Heidari Arash
Published: July 2021

Neuropsychiatric symptoms are a common complication of COVID-19, with symptoms documented both during acute COVID-19 infection (parainfectious) and persisting or developing after the resolution of respiratory symptoms (postinfectious). Patients have presented with a variety of symptoms such as anosmia, thrombotic events, seizures, cognitive and attention deficits, new-onset anxiety, depression, psychosis, and rarely catatonia. Etiology appears to be related to disruption of regular neurotransmission and hypoxic injury secondary to systemic inflammation and cytokine storm. Although rare, catatonia and each of its subtypes have now been reported as complications of COVID-19 and therefore should be considered known to occur in both the parainfectious and postinfectious states. Diagnosis of catatonia in the context of COVID-19 should be considered when work-up for more common medical causes of encephalopathy are negative, there is no identifiable psychiatric etiology for catatonia, and there is a positive response to benzodiazepines.
Equity Effects of Dietary Nudging Field Experiments: Systematic Review
Authors: Schüz Benjamin , Meyerhof Hannah , Hilz Lisa Karla , Mata Jutta
Published: July 2021

Background: Dietary behaviours are among the key modifiable risk factors for non-communicable diseases. Importantly, dietary behaviours vary substantially between groups and individuals with different socioeconomic positions, with more disadvantaged groups and individuals being exposed to more dietary risk factors. The goal of this review is to summarise the existing research on equity effects of dietary nudging interventions.

Methods: Systematic review of nudging interventions conducted in a field setting that report an observable indicator of dietary behaviour, include a control group, and report effect sizes stratified by indicators of socioeconomic status as outlined in the PROGRESS-Plus framework. Two databases (scopus, Pubmed) were searched (last search June 2021), and 18 articles with 19 studies (k = 46 equity comparisons) were included. Risk of bias was assessed using the ROBINS-I tool. Due to heterogeneity in equity dimensions and study outcomes, a harvest plot was used to summarise data.

Results: The majority of equity comparisons (38 out of 46) were available for cognitive nudges. Most of these (22 out of 38 comparisons) found that cognitive nudges worked equally well in more and less disadvantaged populations; however, in 12 out of the 38 comparisons, they favoured those who were less disadvantaged. Two out of four comparisons on behavioural nudges favoured more disadvantaged persons.

Conclusions: The differential effects of dietary nudging interventions in this review can contribute to increases in health inequalities. At the same time, a substantial number of interventions showed no equity effects. Importantly, this review suggests that more research on nudging interventions and health equity is needed. Future interventions should report effect sizes stratified by indicators of social inequality.

Systematic Review Registration: PROSPERO (CRD42019137469)
Knowledge and Use of PEP and PrEP Among Key Populations Tested in Community Centers in Portugal
Authors: Simões Daniel , Meireles Paula , Rocha Miguel , Freitas Rosa , Aguiar Ana , Barros Henrique
Published: July 2021

Background: Pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) have been increasingly available in Europe. Due to the high burden of HIV in key populations, these could benefit from their use. In 2016, in Portugal, an open, non-interval, prospective cohort study was established in a network of 26 community-based voluntary HIV/STI counseling and testing centers. Data collected included questions on PEP and PrEP knowledge and use. We aimed to estimate the proportion of PEP and PrEP knowledge and its use among key populations, visiting the centers between 2016 and 2019.

Method and results: Individuals who self-identify as being among at least one key population for HIV, men who have sex with men (MSM), people who inject drugs (PWID), sex workers (SW), migrants, and male-to-female transgender individuals (MTF), responded to questions on PEP and PrEP knowledge and use while waiting for their test results between 2016 and 2019 (n = 12,893 for PEP; n = 10,973 for PrEP). Reported knowledge was low in all key populations for both tools: 15.7% of respondents reported knowing about PEP and 10.9% about PrEP over the course of 4 years. PEP was used by 1.8% and PrEP by 0.4% of the respondents, MSM being 88.9% of PrEP users, and 52.8% of PEP users. Multivariate logistic regression showed multiple factors associated with knowing the tools, including age, education, country of birth, gender, year of test, having a reactive HIV test in the same visit, reporting an STI or condomless sex in the last 12 months, and identifying with being MSM or SW.

Conclusions: Knowledge and use of PEP and PrEP remain low among key populations in Portugal. The need remains to increase knowledge and use among those at risk for HIV infection.
Higher Leptin-to-Adiponectin Ratio Strengthens the Association Between Body Measurements and Occurrence of Type 2 Diabetes Mellitus
Authors: Liao Pei-Ju , Ting Ming-Kuo , Wu I-Wen , Chen Shuo-Wei , Yang Ning-I , Hsu Kuang-Hung
Published: July 2021

Aim: This case–control study aimed to investigate the interrelations of body measurements and selected biomarkers in type 2 diabetes mellitus (T2DM).

Methods: We recruited 98 patients with T2DM and 98 controls from 2016 to 2018 in Taiwan. Body measurements were obtained using a three-dimensional body surface scanning system. Four biomarkers related to insulin resistance, adipokines, and inflammation were assayed. A multiple logistic regression model was used to perform multivariable analyses.

Results: Four body measurements, namely waist circumference (odds ratio, OR = 1.073; 95% confidence interval, CI = 1.017–1.133), forearm circumference (OR = 1.227; 95% CI = 1.002–1.501), thigh circumference (OR = 0.841; 95% CI = 0.73–0.969), and calf circumference (OR = 1.25; 95% CI = 1.076–1.451), were significantly associated with T2DM. Leptin (OR = 1.09; 95% CI = 1.036–1.146) and adiponectin (OR = 0.982; 95% CI = 0.967–0.997) were significantly associated with T2DM. Six body measurement combinations, namely body mass index, waist-to-hip ratio, waist-to-height ratio, waist-to-thigh ratio, forearm-to-thigh ratio, and calf-to-thigh ratio (CTR), were significantly associated with T2DM. CTR had the strongest linear association with T2DM. Moderating effects of significant biomarkers, namely leptin and adiponectin, were observed. Participants with high leptin-to-adiponectin ratios and in the fourth CTR quartile were 162.2 times more prone to develop T2DM.

Conclusions: We concluded that a combination of leptin and adiponectin modulated the strength of the association between body measurements and T2DM while providing clues for high-risk group identification and mechanistic conjectures of preventing T2DM.
Psychosocial Factors Influencing Outdoor Recreation During the COVID-19 Pandemic
Authors: Mateer Timothy J. , Rice William L. , Taff Brendan Derrick , Lawhon Ben , Reigner Nathan , Newman Peter
Published: July 2021

The COVID-19 pandemic has created an unprecedented disruption to daily life for large swaths of individuals and resulted in potentially widespread implications for individuals' health and wellbeing. This study utilized an online survey of avid outdoor recreationists to understand the psychosocial factors influencing recreationist behaviors during the COVID-19 pandemic across rural, urban cluster, and urban communities in the United States. Confirmatory factor analyses indicate that the five studied psychosocial factors–perceived risk, social norms, recommendations from authority, health benefits, and lifestyle adjustments–exist as unique constructs influencing individuals' outdoor recreation behaviors. Repeated measures analyses suggest individuals rated seeking benefits to their general health as most important when making outdoor recreation decisions, followed by recommendations from authority, then perceptions of risk, with lifestyle adjustments and social norms rated as least important. Lastly, analysis across community types indicated individuals across the rural-urban gradient weighed perceptions of risk and recommendations from authority differently when making outdoor recreation decisions. Managerial implications and future directions for research are discussed.
Diagnosing Norms Surrounding Sexual Harassment at a Jordanian University
Authors: Bergenfeld Irina , Cislaghi Beniamino , Yount Kathryn M. , Essaid Aida A. , Sajdi Jude , Taleb Rand Abu , Morrow Grace L. , D’Souza Janice S. , Spencer Rachael A. , Clark Cari Jo
Published: July 2021

Sexual harassment (SH) is a form of gender-based violence (GBV) that negatively impacts women’s physical, mental, social, and financial well-being. Although SH is a global phenomenon, it also is a contextualized one, with local and institutional norms influencing the ways in which harassment behavior manifests. As more women attend institutions of higher education in Jordan, these women are at increased risk of experiencing SH in university settings, with potential implications for their health and future employment. Social norms theory, which examines the informal rules governing individual behavior within groups, has been a useful framework for understanding and developing interventions against GBV globally. We sought to apply a social-norms lens to the understanding and prevention of SH at a Jordanian university. To gain a comprehensive and nuanced picture of social norms surrounding SH, we collected qualitative data using three complementary methods: focus group discussions (n = 6) with male and female students (n = 33); key informant interviews with staff and faculty (n = 5); and a public, participatory event to elicit anonymous short responses from students (n = 317). Using this data, we created a codebook incorporating social-norms components and emergent themes. As perceived by participants, SH was unacceptable yet common, characterized as a weak norm primarily because negative sanctioning of harassers was unlikely. Distal norms related to gender and tribal affiliation served to weaken further norms against SH by blaming the victim, preventing reporting, discouraging bystander intervention, and/or protecting the perpetrator. The complexity of the normative environment surrounding SH perpetration will necessitate the use of targeted, parallel approaches to change harmful norms. Strengthening weak norms against SH will require increasing the likelihood of sanctions, by revising university policies and procedures to increase accountability, increasing the acceptability of bystander intervention and reporting, and fostering tribal investment in sanctioning members who harass women. Creating dialogue that emphasizes the harmful nature of SH behaviors and safe spaces to practice positive masculinity also may be an effective strategy to change how male students interact in the presence of peers. Any social norms change intervention will need to consider the various reference groups that dictate and enforce norms surrounding SH.
Progress, but at the Expense of Male Power? Institutional Resistance to Gender Equality in an Irish University
Authors: Hodgins M. , O’Connor P.
Published: July 2021

Gender equality is a whole-organization endeavor. Building on Agócs (Journal of Business Ethics, 1997, 16 (9), 917–931) concept of institutionalized resistance this article undertakes a feminist critique of policy and practice around internal promotions to the equivalent of Associate Professor level in one Irish university (called the Case Study University). This university was selected because of its low proportion of women in senior academic positions. The methodology is a single case study design, employing documentary analysis, including secondary data. Since 2013 the proportion of women at Associate Professor in the Case Study University increased significantly (bringing them close to the national average): this being associated with increased transparency, with the cascade model in the background. However, men’s “chances” have varied little over time and at 1:4 are the highest in Irish universities. This article uses Agócs (Journal of Business Ethics, 1997, 16 (9), 917–931) stages of institutional resistance to show that while some changes have been made, ongoing institutionalized resistance is reflected in its failure to accept responsibility for change as reflected in its refusal to challenge the “core mission” and restricting the focus to “fixing the women”; and its failure to implement change by focusing on “busy-ness” which does not challenge power and colluding with foot-dragging and slippage in key areas. It is suggested that such institutional resistance reflects the enactment of hidden or stealth power. The article implicitly raises questions about the intractability and the covertness of men’s power and privilege and the conditions under which women’s “chances” are allowed to improve, thus providing insights into the extent and nature of institutional resistance.
Chlorella Vulgaris Photobioreactor for Oxygen and Food Production on a Moon Base—Potential and Challenges
Authors: Detrell Gisela
Published: July 2021

A base on the Moon surface or a mission to Mars are potential destinations for human spaceflight, according to current space agencies’ plans. These scenarios pose several new challenges, since the environmental and operational conditions of the mission will strongly differ than those on the International Space Station (ISS). One critical parameter will be the increased mission duration and further distance from Earth, requiring a Life Support System (LSS) as independent as possible from Earth’s resources. Current LSS physico-chemical technologies at the ISS can recycle 90% of water and regain 42% of O2 from the astronaut’s exhaled CO2, but they are not able to produce food, which can currently only be achieved using biology. A future LSS will most likely include some of these technologies currently in use, but will also need to include biological components. A potential biological candidate are microalgae, which compared to higher plants, offer a higher harvest index, higher biomass productivity and require less water. Several algal species have already been investigated for space applications in the last decades, being Chlorella vulgaris a promising and widely researched species. C. vulgaris is a spherical single cell organism, with a mean diameter of 6 µm. It can grow in a wide range of pH and temperature levels and CO2 concentrations and it shows a high resistance to cross contamination and to mechanical shear stress, making it an ideal organism for long-term LSS. In order to continuously and efficiently produce the oxygen and food required for the LSS, the microalgae need to grow in a well-controlled and stable environment. Therefore, besides the biological aspects, the design of the cultivation system, the Photobioreactor (PBR), is also crucial. Even if research both on C. vulgaris and in general about PBRs has been carried out for decades, several challenges both in the biological and technological aspects need to be solved, before a PBR can be used as part of the LSS in a Moon base. Those include: radiation effects on algae, operation under partial gravity, selection of the required hardware for cultivation and food processing, system automation and long-term performance and stability.
Poultry Response to Heat Stress: Its Physiological, Metabolic, and Genetic Implications on Meat Production and Quality Including Strategies to Improve Broiler Production in a Warming World
Authors: Nawaz Ali H. , Amoah Kwaku , Leng Qi Y. , Zheng Jia H. , Zhang Wei L. , Zhang Li
Published: July 2021

The continuous increase in poultry production over the last decades to meet the high growing demand and provide food security has attracted much concern due to the recent negative impacts of the most challenging environmental stressor, heat stress (HS), on birds. The poultry industry has responded by adopting different environmental strategies such as the use of environmentally controlled sheds and modern ventilation systems. However, such strategies are not long-term solutions and it cost so much for farmers to practice. The detrimental effects of HS include the reduction in growth, deterioration of meat quality as it reduces water-holding capacity, pH and increases drip loss in meat consequently changing the normal color, taste and texture of chicken meat. HS causes poor meat quality by impairing protein synthesis and augmenting undesirable fat in meat. Studies previously conducted show that HS negatively affects the skeletal muscle growth and development by changing its effects on myogenic regulatory factors, insulin growth factor-1, and heat-shock proteins. The focus of this article is in 3-fold: (1) to identify the mechanism of heat stress that causes meat production and quality loss in chicken; (2) to discuss the physiological, metabolic and genetic changes triggered by HS causing setback to the world poultry industry; (3) to identify the research gaps to be addressed in future studies.
Intelligent Network Intrusion Prevention Feature Collection and Classification Algorithms
Authors: Selva Deepaa , Nagaraj Balakrishnan , Pelusi Danil , Arunkumar Rajendran , Nair Ajay
Published: July 2021

Rapid Internet use growth and applications of diverse military have managed researchers to develop smart systems to help applications and users achieve the facilities through the provision of required service quality in networks. Any smart technologies offer protection in interactions in dispersed locations such as, e-commerce, mobile networking, telecommunications and management of network. Furthermore, this article proposed on intelligent feature selection methods and intrusion detection (ISTID) organization in webs based on neuron-genetic algorithms, intelligent software agents, genetic algorithms, particulate swarm intelligence and neural networks, rough-set. These techniques were useful to identify and prevent network intrusion to provide Internet safety and improve service value and accuracy, performance and efficiency. Furthermore, new algorithms of intelligent rules-based attributes collection algorithm for efficient function and rules-based improved vector support computer, were proposed in this article, along with a survey into the current smart techniques for intrusion detection systems.
Using the Nonlinear Duffing Effect of Piezoelectric Micro-Oscillators for Wide-Range Pressure Sensing
Authors: Zengerle Tobias , Stopp Michael , Ababneh Abdallah , Seidel Helmut
Published: July 2021

This paper investigates the resonant behaviour of silicon-based micro-oscillators with a length of 3600 µm, a width of 1800 µm and a thickness of 10 µm over a wide range of ambient gas (N2) pressures, extending over six orders of magnitude from 10−3 mbar to 900 mbar. The oscillators are actuated piezoelectrically by a thin-film aluminium-nitride (AlN) layer, with the cantilever coverage area being varied from 33% up to 100%. The central focus is on nonlinear Duffing effects, occurring at higher oscillation amplitudes. A theoretical background is provided. All relevant parameters describing a Duffing oscillator, such as stiffness parameters for each coverage size as well as for different bending modes and more complex modes, are extracted from the experimental data. The so-called 2nd roof-tile-shaped mode showed the highest stiffness value of −97.3∙107 m−2s−2. Thus, it was chosen as being optimal for extended range pressure measurements. Interestingly, both a spring softening effect and a spring hardening effect were observed in this mode, depending on the percentage of the AlN coverage area. The Duffing-effect-induced frequency shift was found to be optimal for obtaining the highest pressure sensitivity, while the size of the hysteresis loop is also a very useful parameter because of the possibility of eliminating the temperature influences and long-term drift effects of the resonance frequency. An reasonable application-specific compromise between the sensitivity and the measurement range can be selected by adjusting the excitation voltage, offering much flexibility. This novel approach turns out to be very promising for compact, cost-effective, wide-range pressure measurements in the vacuum range.
Tracking Model Predictive Control for Docking Maneuvers of a CubeSat with a Big Spacecraft
Authors: Stesina Fabrizio
Published: July 2021

The release and retrieval of a CubeSat from a big spacecraft is useful for the external inspection and monitoring of the big spacecraft. However, docking maneuvers during the retrieval are challenging since safety constraints and high performance must be achieved, considering the small dimensions and the actual small satellites technology. The trajectory control is crucial to have a soft, accurate, quick, and propellant saving docking. The present paper deals with the design of a tracking model predictive controller (TMPC) tuned to achieve the stringent docking requirements for the retrieval of a CubeSat within the cargo bay of a large cooperative vehicle. The performance of the TMPC is verified using a complex model that includes non-linearities, uncertainties of the CubeSat parameters, and environmental disturbances. Moreover, 300 Monte Carlo runs demonstrate the robustness of the TMPC solution.
Decentralized Control of Nanosatellite Tetrahedral Formation Flying Using Aerodynamic Forces
Authors: Ivanov Danil , Monakhova Uliana , Guerman Anna , Ovchinnikov Mikhail
Published: July 2021

A decentralized control algorithm for the construction of a tetrahedral configuration using differential lift and drag forces is proposed in this paper. Four 3U CubeSats launched in LEO are considered. Satellite attitude-controlled motion relative to the incoming airflow provides the required differential forces in order to change the relative translational motion. The developed control algorithm allows one to track the relative reference trajectories for the satellites at the vertices of the tetrahedron of the required shape and size. The influence of the initial launch conditions on the controlled tetrahedral motion is studied in this paper.