bluuebunny/crossref_metadata_2025 huggingface dataset:
Fuel for thought? Developments in CMA local merger assessment
Authors: Gore Daniel
Published: February 2022

This article considers ongoing developments in the Competition and Markets Authority's approach to local merger assessment as highlighted by its recent EG/Asda Phase I decision. The CMA appears to be moving away from its traditional two-stage approach of applying initial competition filters augmented by detailed local assessment of cases identified by those filters, and towards a binary system determined solely on the basis of mechanical rules. This shift has been justified on the grounds of procedural efficiency and as providing a more systematic approach to local merger review. This article demonstrates that the CMA's decisional practice shows that the move away from two-stage filtering is not justified by efficiency considerations, and that the emerging approach of using mechanical rules reduces the quality of merger control by disregarding relevant evidence at the expense of relatively crude structural thresholds. Whereas merger control over the past two decades has generally moved away from thresholds based on numbers of firms or market shares, the CMA's adoption of mechanical decision rules appears to be moving back towards such an approach for the Phase I assessment of local mergers. The new approach may be related to a more general CMA shift towards avoiding the risk of under-intervention in merger review, even if this is at the expense of increasing over-intervention. While the new approach to local merger review may be expected to generate greater intervention, however it will not address any perceived risk of under-intervention.
Roedores da Bacia do Alto Paraguai: uma revisão do conhecimento do planalto à planície pantaneira
Authors: Antunes Pâmela Castro , Miranda Cleuton Lima , Hannibal Wellington , Godoi Maurício Neves , Aragona Mônica , Mozerle Hugo Borghezan , Rademaker Vitor , Santos-Filho Manoel , Layme Viviane M. G. , Brandão Marcus Vinicius , B. F. Semedo Thiago
Published: February 2022

A ordem Rodentia representa aproximadamente 39% da diversidade mundial de mamíferos, sendo que para o Brasil são reconhecidos atualmente 76 gêneros e 263 espécies. Para a Bacia do Alto Paraguai (BAP), foi registrada a ocorrência de 42 espécies, distribuídas em oito famílias: Sciuridae (2 gêneros, 2 espécies), Cricetidae (15, 27), Caviidae (3, 3), Ctenomyidae (1, 1), Cuniculidae (1, 1), Dasyproctidae (1, 1), Erethizontidae (1, 1) e Echimyidae (5, 6). Dentre as espécies registradas na BAP, duas foram recentemente descritas, Akodon kadiweu e Oecomys matogrossensis, uma revalidada em nível de espécie, Coendou boliviensis, e três são alvo de caça, Cuniculus paca, Dasyprocta azarae e Hydrochoerus hydrochaeris. A proposta deste artigo foi fazer um levantamento de todas as espécies de roedores registradas na BAP até o presente momento, trazendo, na medida da disponibilidade de dados, a descrição morfológica de cada uma das 42 espécies, bem como a comparação com espécies congêneres ou assemelhadas, a revisão dos dados de ecologia e de história natural e informações específicas de suas populações e de seus graus de ameaça. Por fim, este estudo traz informações inéditas, que podem ser utilizadas para a tomada de decisões em políticas públicas e para o norteamento de pesquisas básicas para esse grupo zoológico nessa região tão pouco conhecida e fortemente ameaçada.
Müzelerde Etkileşimli Bilgilendirme Tasarımı: Anadolu Medeniyetleri Müzesi ile Frankfurt Tarih Müzesi’nin Karşılaştırılması
Authors: ÖZDEN Kansu
Published: February 2022

Müzeler yıllardır süregelen somut yaşantıların gerçekleştirilebileceği kalıcı öğrenmelerin sağlanabileceği okul dışı bir eğitim kurumu görevi üstlenmektedir. Bu görevi üstlenirken de klasik sergileme biçimlerini değiştirerek, modern müzecilik anlayışı çerçevesinde etkileşime girilebilecek cihazlar yardımıyla, çevrim içi platformlarıyla ziyaretçilerin deneyim kalitelerini artırmayı hedeflemektedir. Son yıllarda teknolojinin gelişimi ve özellikle pandemi sebebiyle müzelerin çevrim içi ziyaretleri; ziyaret öncesi ve sonrası etkileşim için önem kazanmıştır. Çevrim içi kullanımın çeşitli sınırlılıkları ortadan kaldırması fiziki ziyaretler kadar çevrim içi ziyaretleri de önemli hale getirmiştir. Fakat çevrim içi müzelerin etkili şekilde kullanılabilmesi amacıyla web sitelerinin anlaşılır, ilgi çekici, kullanışlı, ulaşılabilir, kapsamlı ve ziyaretçi niteliklerine göre düzenlenmesi gerekmektedir. Bu çalışma da yurt dışından ve yurt içinden birer müze örneklem şeklinde kullanılarak müzelerin, fiziki ve çevrim içi etkileşimli bilgilendirme tasarımı uygulamalarını değerlendirmek, her iki müzenin mevcut durumdaki farklılıklarını, ortak yanlarını ortaya koymayı ve çıkan sonuçları karşılaştırmayı amaçlamıştır. Müze, sanal müze ve etkileşimli bilgilendirme tasarımı gibi kavramlar ve bu kavramların ilişkili bulunduğu diğer kavramların tanımlarına da çalışma da yer verilmiştir. Nitel araştırma yöntemlerinden doküman analizi kullanılmıştır. Çalışmanın gerçekleştirilmesi için Frankfurt Tarih Müzesi ve Anadolu Medeniyetleri Müzesi fiziki etkileşimli bilgilendirme tasarım imkânları, web siteleri, sosyal medya hesapları incelenmiş bilgiler detaylı şekilde ortaya konmuştur. Ulaşılan bilgiler tartışılmış ve sonuç bölümünde belirtilmiştir.
The effect of fenugreek seeds (Trigonella foenum-Gracecum) supplementation on glycemic status, androgens, and lipid profile in letrozole induced polycystic ovarian syndrome (PCOS) model
Authors: Lodhi Bushra manzoor , Uzma Firdous
Published: February 2022

Introduction: PCOS the most common endocrinopathy of reproductive-aged females is hallmarked by characteristics of polycystic ovary syndrome and biological hyperandrogenism and hyperinsulinism. Fenugreek seeds have proven to be beneficial in the treatment of PCOS because of their antiandrogenic and anti-hyperglycaemic effects. The present study was aimed to evaluate the effect of aqueous extract of fenugreek seed in PCOS rats. Materials and method: Twenty-four female Wistar rats were divided into two groups: Group 1 served as a (control group, n=10) received saline (0.9%NaCl) while Group 2 (PCOS control group, n=30) received letrozole (1mg/kg) to induce PCOS. After 21 days, PCOS-induced rats were divided into two groups. One group was treated with the aqueous extract of fenugreek seeds and another group was treated with metformin (300mg/Kg) for 21 consecutive days while the control group continued to receive saline. At the end of the experiment ovaries were removed for histological examination and blood collected for the estimation of Insulin, Testosterone, and Lipid profile. Result: Compared with the control group, Letrozole administration in rats exhibited significant alterations in serum testosterone, insulin activity, glucose and Lipid profile (P<0.001). Acyclicity of the estrus cycle with cysts were also detected. In Fenugreek and metformin groups restoration of normal ovarian stroma, normalization of estrous cycle with reduced levels of testosterone (P<0.001), insulin (P<0.001), glucose (P<0.001), and cholesterol (P<0.0001) were observed. Discussion: These findings suggest that aqueous extract of fenugreek showed better amelioration in the regulation of impaired insulin resistance, hyperandrogenaemia, and ovarian dysfunction in PCOS.
A Journal for a Culture of Collaborative, Science-Oriented, Clinical Thinking
Authors: Laddis Andreas
Published: February 2022

This editorial is to announce ending the publication of Frontiers in the Psychotherapy of Trauma and Dissociation and to share my sadness, pride, and hopes as the Editor of Frontiers. With much pride and deep sadness I will reminisce about the vision and ambitions presented with the inaugural issue three years ago. Then, I will highlight a few particular collections of articles to demonstrate how, I believe, a clinical journal could become a great asset for ISSTD moving forward. It could be a powerful means for a culture of collaborative, science-oriented, clinical thinking in the Society. My hope is that Frontiers has stirred the ISSTD members’ interest and expectations for a clinical journal dedicated to psychotherapy for complex, trauma-related mental disorders.
Bienestar psicológico durante la pandemia Covid-19 en mujeres de una asociación del municipio de Zacapa
Authors: Chó Paiz Nataly Mercedes
Published: February 2022

OBJETIVO: evaluar los grados de bienestar psicológico de las integrantes de una asociación de mujeres del municipio de Zacapa durante la pandemia Covid-19; evidenciando los factores asociados a los niveles de bienestar psicologico. MÉTODO: se desarrolló un estudio descriptivo transversal en 105 mujeres pertenecientes a una asociación del municipio de Zacapa. RESULTADOS: por medio del presente estudio se evidenció que el rango etario con mayor frecuencia de las mujeres participantes fue de 37 a 48 años que prevaleció con un 60% (N=63), de acuerdo al estado civil en su mayoría las mujeres indicaron ser unidas con un 46.7% (N=49), el 50.5% (N=53) de las mujeres ha concluido únicamente el nivel académico primario y el área laboral que desempeña el 60.9% (N=64) de las mujeres es en el sector privado. Mediante la evaluación de bienestar psicológico de acuerdo a la escala de Ryff la mayor cantidad de mujeres manifestaron un grado de bienestar psicológico bajo, lo cual se representa con el 39.1% (N=41) de la población y se determinó que el incremento de deudas presenta una mayor incidencia durante la Covid-19, lo cual se representa con el 68.6 % (N=72) de la población. CONCLUSIÓN: existe una relación entre los niveles bajos de bienestar psicológico y el incremento de deudas durante la pandemia Covid-19 en las mujeres participantes del presente estudio, representado con un valor de p menor de 0.00001; siendo estadísticamente significativo.
Factors and Reasons That Influenced The Misyar Marriage Phenomenon in Surabaya Urban Communities
Authors: Rochman Firdian Mochamad
Published: February 2022

This study aims to analyze the factors and reasons behind the Misyar marriage phenomenon in Surabaya urban communities. The practice of misyar marriage is a marriage in which the husband visits the wife's residence, but the wife is reluctant to move to the husband's residence. In the context of the phenomenon of marriage agreement (a study of the practice of misyar marriage in the urban community of Surabaya), each party also has a different background and purpose. This study used descriptive qualitative studi, it describes in a structured, accurate, and factual manner related to the problems that occur, which include cases of misyar marriage practices in the urban community of Surabaya. The results show that the practice of misyar marriage in the urban community of Surabaya has unique characteristics that are different from the initial form of misyar marriage carried out by the Arab community. Based on the information obtained from the perpetrators and informants, in the practice of misyar marriage in the urban community of Surabaya the factors behind this phenomenon are factors of family social needs, factors of religious understanding, biological factors, life choices factors, socio-cultural factors, and economic factor
Management of Academic Services in Building Student Satisfaction in Private Islamic Religious College: A Descriptive Qualitative Analysis Study at STAI Al Musaddadiyah, STAI Darul Arqam, And Stai Persis in Garut Regency
Authors: Nasrullah Yufi Mohammad , Tb. Abin Syamsudin  , Sauri Sofyan , Warta Waska
Published: February 2022

This research is motivated by student dissatisfaction with academic services, who are often dissatisfied with the academic services provided, such as facilities and staff performance that are not in line with the expectations of students as customers. This study aims to provide an overview of academic service management in building student satisfaction which includes: (1) Planning; (2) Implementation; (3) Evaluation; (4) Results and achievements; (5) Supporting factors; (6) Inhibiting factors; (7) Hope; (8) Solution. This research method used a descriptive method with a qualitative approach and case study design, in the process by observation, interviews and documentation. The management theory appropriate for the service is the modern management theory. Terry. G. clarifies these management functions in four parts, namely as follows: planning (Planning), organizing (Organizing), actuating, and controlling (Controlling). The results of the study show that there was a different understanding and implementations where STAI Al Musaddadiyah established the process of academic services in the expanding student’s satisfaction which was supported by an academic service information system, STAI Darul Arqam was supported by an integrated program from the centre, a program of learning supports STAI Persis. All components, policymakers, authorities, and interested parties were required to support the realization of good quality academic services. The achievement of quality academic services would build creative, innovative, productive resources and had the value of independence to build self-potential in creating a quality culture in private Islamic religious colleges
Pengaruh Sistem Informasi Penerimaan Pajak Reklame terhadap Peningkatan Pendapatan Asli Daerah Kabupaten Bengkalis
Authors: Mahalizikri Irawan Fakhrudin , Arnabilla Nurfaizana
Published: February 2022

This article aims to determine the effect of the advertisement tax revenue information system on increasing the local revenue of Bengkalis Regency. The information system applied is still using the advertisement information system manually. Where the manual information system is applied: the first is the information system for the management and calculation of the advertisement tax, the second is the information system for the appeal of the taxpayer and the organizer of the advertisement tax through electronic media and the third banner is the information system for the recapitulation of targets and realization of the advertisement tax using the standard application of Microsoft Excel. The researcher used the collection techniques: interviews, documentation, questionnaires, and literature studies. The data analysis technique used: respondent's data test, data quality test, classical assumption test, hypothesis test and simple linear regression test, while the results studied were known in the t-test (partial) that the value of tcount 8.168> ttable 1.983. Meanwhile, based on the significant value of the t-test (partial) it can be seen in the sig table column that the significant value is 0.000 <0.05. So it can be concluded that there is an influence between the Advertising Tax Revenue Information System variable (X) on the Regional Original Income Increase variable (Y) by 39.3%, the rest is influenced by other variables of 60.7%
Produksi Tempe Kedelai dalam Perspektif Ekonomi Islam
Authors: Nurhayati Ana , Siagian Seri Yanti , Sai'in Sai'in
Published: February 2022

The production of soybean tempeh is a business run by the owner of soy tempeh in Tembilahan city using fermented soybean as raw material and has good nutritional value for human health. This study aims to determine the production of soybean tempeh in the city of Tembilahan and to determine the production of soybean tempeh from an Islamic economic perspective. This type of research is qualitative research. The subject of this research is the owner of the soybean tempe production site in the city of Tembilahan, totaling 4 tempe owners. While the object of research is the production of soybean tempe in the city of Tembilahan in the perspective of Islamic economics. The data was collected by interview, observation and documentation. The conclusion of this research is the soybean tempeh production has not fully carried out the production process according to the perspective of Islamic economics, this can be seen from the discrepancy in the application of work in fields that are permitted by Allah, namely in one of the production sites, namely the application of the system. wages to workers and reduction of scales that have been regulated in Surah Al-Hadid verse 25 and Al-Isra verse 35
Motivasi Peternak Melakukan Pemurnian Sapi Bali
Authors: Saleh Ikrar Mohammad , Rasyid Tanri Giling , Siregar Ahmad Ramadhan , Amrullah  , Hatta Muhammad , Darwis Muhammad , Astaman Putra
Published: February 2022

Upaya untuk menjaga potensi sapi bali di Kabupaten Barru yang harus dijaga sebagai plasma nutfah adalah bagaimana peternak tetap termotivasi untuk melakukan pemurnian sapi bali. Sapi bali memiliki strategi signifikan dan peran penting, serta peluang pasar yang menjanjikan karena merupakan sapi asli penghasil daging nasional yang terbukti mampu beradaptasi dengan kondisi lokal yang patut mendapat perhatian. Tujuan penelitian ini adalah untuk mengetahui motivasi peternak melalukan pemurnian Sapi Bali di Kecamatan Tanete Riaja Kabupaten Barru Provinsi Sulawesi Selatan. Penelitian ini dilakukan pada empat kelompok tani ternak dengan populasi peternak sebanyak 140 orang. Jumlah sampel mengunakan rumus slovin dan metode stratified random sampling sebanyak 58 orang dengan sebaran yaitu Kelompok Tani Ternak Lempangeng 12 orang, Makkawaru 22 orang, Sipurennue 12 orang dan Lempang 12 orang yang diambil secara acak. Data dikumpulkan melalui wawancara dengan bantuan kuisioner yang diukur dengan menggunakan skala likert yaitu skor 1 sampai 3 dengan kategori 1 = tidak baik; 2 = sedang; dan 3 = baik serta dianalisis dengan menggunakan analisis deskriptif. Hasil penelitian menunjukkan bahwa peternak di Kecamatan Tanete Riaja Kabupaten Barru termotivasi dalam melakukan pemurnian sapi bali karena adanya tuntutan ekonomi keluarga, dapat meningkatkan status sosial, adanya waktu luang yang dimiliki peternak, peluang mendapatkan hasil yang lebih besar, dan tambahan pendapatan.
A Study of Bullying on Social Media among Senior Secondary School Students With Reference to Gender and Type of School
Authors:   Post Doctoral Fellow, ICSSR, New Delhi, India, Fatima Dr. Tabassum
Published: February 2022

Bullying on various social media platforms is a new societal issue that has gotten a lot of attention from academics. It has been recognized as a serious health issue among adolescents. Cyber bullying can take many different forms. It doesn't always imply breaking into someone's accounts or pretending to be someone else. It also includes making disparaging remarks about someone or circulating rumors in order to slander them. Because everyone is engrossed in social media, it is quite easy for anyone to abuse their access. The present study is an attempt to analyze various aspects of bullying on social media among senior secondary school students. The study has also taken into consideration the type of school (government and private) and gender variables which was carried out on the sample of 305 senior secondary school adolescents of Aligarh district. The study has revealed mixed results which have been interpreted with some suggestive measures.
Smart Policing of Madhy Pradesh Dial-100 (Special reference to Sagar District)
Authors:   Research Scholar (Criminology) Department of Criminology and Forensic Science Dr. Harisingh Gour University, Upadhyay Rupesh Kumar
Published: February 2022

Police and public depend on each other; without one another can’t survive. Madhya Pradesh became India’s first state for using this effective modern technology for crime prevention & providing emergency help to victim at crime scene. It got tag of India’s first & largest integrated police emergency response service. This study explores the system, strategy and functional techniques of dial-100 at Sagar district of Madhya Pradesh state. It also analysis about cases reported through dial- 100 as road accident, children related, women related crime body etc. This project stands to police having GPS, GIS, and MDT at victim’s door within a little minute at one call or miscall. The police are one of the most visible and recognizable institution in modern society. Dial-100 team works also as surveillance, spot counseling and vigilance and FRV works as surveillance vehicle through event and round events. The team controls crime and help victims in the district with 26 FRV over 2378458 populations and one FRV covers 91479.15 populations. This smart policing not only reduces crime but also puts an example of humanity in society.
Factores pronósticos en nefritis lúpica
Authors: Alba Paula
Published: February 2022

El compromiso renal es reconocido como una de las complicaciones más serias en el LES, que ocurre a menudo dentro de los primeros cinco años de la enfermedad y es uno de los factores predictores de morbilidad y mortalidad. El pronóstico de pacientes con LES ha mejorado significativamente en las últimas décadas. La sobrevida de pacientes con NL también se ha incrementado a más del 80% a los 5 años en la década del 90 comparado con el 50% previo reportado en los años 604. La mejoría es particularmente marcada en los tipos proliferativos de glomerulonefritis y puede ser atribuido al reconocimiento y diagnóstico temprano así como al uso de terapias como los agentes citotóxicos y un mayor acceso a la diálisis y al trasplante. Numerosos estudios epidemiológicos en pacientes con NL han sido publicados y más de trece factores de riesgo independientes predictores de progresión han sido identificados.
Osteólisis multicentrica no hereditaria con nefropatia
Authors: Ferreyra-Garrott Leandro , Meneses Gabriel , Plantalech Luisa
Published: February 2022

La osteólisis idiopática multicéntrica (OIM) se caracteriza por el com-promiso de carpos y de tarsos, con inﬂamación y dolor; se inicia en la infancia y se autolimita en la 2a o 3a década de la vida. Según Har-degger, se describen tipos hereditarios dominantes (tipo I) o recesivos asociados a osteoporosis (tipo II), OIM esporádicas con compromiso renal (tipo III) u osteólisis masiva monocéntrica (tipo IV). El tipo V se caracteriza por clínica similar al tipo II asociada a lesiones oculares o dermatológicas y talla baja.
To Evaluate Clinical Efficacy of Ashtang Lavan Churnin Alcohol Addiction.
Authors: Charak Sandeep , Sharma Dharminder Kumar , Sharma Monika
Published: February 2022

Background-Alcoholism is a growing public health and socioeconomic problem around the world. Around 20% of the alcohol drank is absorbed by the stomach. The remaining 80% is mostly absorbed by the small intestine. The circulatory system also delivers alcohol to the liver, which uses a process known as "metabolizing" to remove it from the bloodstream by converting it to a harmless molecule. Because the liver can only digest a certain amount at a time, the rest circulates throughout the body. Aim-To assess the clinical efficacy of Ashtang Lavanin Alcohol addiction and withdrawal symptoms. Materials and Methods-The clinical efficacy of Ashtang Lavanin the treatment of alcohol addiction and withdrawal symptoms was evaluated using a randomized single blind technique. Ashtang Lavanwas administered to one group to help with hepatotoxicity and withdrawal symptoms such as sleeplessness, anxiety, and agitation. Before and after therapy, the Clinical Institute Withdrawal Assessment-Alcohol revised (CIWA-Ar) scale was used to examine the clinical symptoms of alcohol withdrawal. Clinical manifestations of alcohol withdrawals recorded between 5 and 10 hours after ceasing to drink were used as a baseline for before therapy, while clinical manifestations of withdrawals after 1 month were used as a baseline for after treatment. Result-There were 26.66 percent of patients in one group who reported excellent alleviation. Conclusion-Throughout the clinical trial, 36.00 percent of patients in one group were found to be de-addicted.
DESARROLLO DE LA INTELIGENCIA EMOCIONAL EN EL EMPRENDIMIENTO EDUCATIVO EN LOS ESTUDIANTES DE BACHILLERATO GENERAL DE LA UNIDAD EDUCATIVA "LIBERTAD”
Authors: García Mera María Estela , Rodríguez Loor Grace Beatriz
Published: February 2022

La presente investigación tiene como objetivo establecer la influencia del desarrollo de habilidades de inteligencia emocional en el emprendimiento educativo de los estudiantes de la Unidad Educativa Libertad. La metodología tiene un enfoque cuantitativo, utilizando los métodos: científico, deductivo y analítico, con la participación de 86 estudiantes y 10 docentes, el instrumento utilizado fue la encuesta en formato online, mediante Google forms. Los resultados obtenidos, determinaron la carencia en el desarrollo de habilidades de inteligencia emocional con respecto al emprendimiento formativo como habilidad que contribuye al crecimiento personal y educativo del alumnado. Se precisa que los estudiantes son conscientes que el adecuado manejo de sus emociones, constituye una competencia esencial en el ámbito personal como profesional.
PENGARUH PENAMBAHAN BAHAN ADITIVE ANTI STRIPPING TERHADAP KINERJA CAMPURAN ASPAL
Authors: Simanjuntak Refanti Angelia , Radam Iphan Fitrian
Published: February 2022

Anti Stripping Agent adalah aditif yang dapat merubah sifat aspal dan agregat serta meningkatkan daya lekat sehingga memperpanjang umur rencana, mengurangi efek negatif dari air dan kelembaban. Hal ini akan mengurangi terjadinya pelepasan butiran pada aspal. Penelitian dilakukan di laboratorium. Dibuat benda uji untuk pengujian Marshall. Tujian penelitian adalah mengetahui nilai optimum penggunaan Anti Stripping Agent jenis T-MEN L300A dengan kadar 0%, 0,3%, 0,5%, 0,7%, 0,9%, dan 2%. Hasil penelitian dengan Anti Stripping Agent didapat nilai optimum sebesar 0,45%. Berdasarkan analisis didapat bahwa aditif memepengaruhi nilai VIM dan flow. Batas penggunaan maksimal aditif sebesar 0,9% yang memenuhi Spesifikasi Umum Bina Marga 2018.
Assessment of Interleukin_10 level in Sudanese Patients with Chronic Lymphocytic Leukemia in Khartoum State
Authors:   Department of Hematology, Faculty of Medical Laboratory Science, International University Khartoum, Sudan, Yahia Abdelmula Waha Ismail , Taher Gorish Babbiker Mohammed ,   Department of Microbiology, Faculty of Medical Laboratory Science, Omdurman, Islamic University, Sudan
Published: February 2022

Background: Chronic lymphocytic leukemia (CLL) is the most predominant leukemia among adults. Interleukin‑10 (IL‑10) secretion has potent immunosuppressive effects and it has a strong stimulating impact on B-lymphocytes, inducing proliferation and differentiation. This study was conducted to investigate the serum levels of IL-10 in patients with CLL (cases) and comparing them with apparently healthy age and gender match volunteers as control group. Method: A total of 88 blood samples were randomly collected. 44 blood samples were withdrawn from cases, while the rest were obtained from control. Serum samples after centrifugation of blood were obtained for IL-10 level evaluation. Human IL-10 ELISA max Deluxe kit was used to determine IL-10 in each sample following manufacture instructions. The Data was analyzed through statistical package for the social science (SPSS) version 20. Results: Our results showed that the mean of IL_10 level among CLL patients (22.7±5.34 pg\ml) was significantly higher (P-value: 0.002) than the mean of IL_10 level among control group (4.99±0.55 pg\ml). Among case groups females showed IL-10 mean of 29.09±10.85 pg/ml that was significantly higher than male’s 18.22±5.04 pg/ml with p-value 0.023. Our result finds no significant difference between cases below 55years (23.62±8.03 pg/ml) and above55 years (22.07±7.19 pg/ml) in the level of IL-10 with P-value 0.893. Conclusion: In conclusion, this study determined higher serum IL-10 levels in CLL patients compared with healthy controls. Gender and duration of disease have significant effect on serum IL-10 level among CLL cases. However, sample size in this study was small and larger scale research is needed in this field with the inclusion of several factors such as disease, grade and outcome.
Inhibition in Proper Ser and In Plcγ2 Synthesis Are the Main for Causing Osteoarthritis, Diabetes, and C-Lymphocytic Leukemia Diseases
Authors:   Biomedical Molecular Studies Pathologies and Cancer Diseases Canada, Toronto, Goldwin Avenue west and Egypt, El Tantawi Ashraf Marzouk
Published: February 2022

Proper S6K /BTK and PLCγ2 synthesis (which regulated by Ser phosphorylation pathway) are main regulations for thromboxane-A “TXA2” synthesis, and necessary for B-cell maturations and T-cells modulations and functions. The main reasons for causing Osteoarthritis “OA” and diabetes diseases (that are linked together) are the deficiency of Ser amino acids and decreasing of Ser phosphorylation signalling pathway which necessary for proper S6K productions, where normally the Ser phosphorylation signalling pathway is the basis of Ser /Thr phosphorylation signalling and is necessary for proper Akt, S6K1 synthesis and necessary for RORs and IFNs synthesis and also necessary for running proper BTK for PLCγ2 productions , where S6K is main regulator for ATPase and for proper PLCγ1 and for PLCγ2 synthesis which necessary for bone growth and for modulating immune efficiency. Osteoarthritis “OA” is characterized by a sharp expression in Gamma-Phospholipase C-1 “PLCγ1”, with decreasing “or inhibition” in PLCγ2 “PLC beta” productions due to inhibition or mutation in S6K and then in BTK. The increasing in PLCγ1 with Deficiency in Ser amino acids will lead to deficiency in Ser phosphorylation signalling, and decreasing in synthase activity that will reflect down regulations in BTK pathways and lead to inhibition in PLCγ2 productions which will reflect diabetes (inhibition in Estrogen with the production of Androgen instead of estrogen) and can reflect Osteoarthritis “OA” prognosis depend on the percentage of Deficiency or inhibition in basic amino acids and its basic necessary signaling pathways.
Smart Mucoadhesive Film Former from Seeds of Arachis Hypogea and Its In-Built Properties for Pharmaceutical Applications
Authors:   Faculty of Pharmacy, Dit University, Mussoorie Diversion Road, Guru Nanak College of Pharmaceutical Sciences, Banshiwala, Jhajra, Dehradun, India, Varshney Sugandha , Satheesh Madhav Nookala Venkala ,   Faculty of Pharmacy, Dit University, Mussoorie Diversion Road, Formulation research development, vital therapeutics and formulations, Telangana, India
Published: February 2022

Aim: Isolation of novel biopolymer from Arachis hypogea seeds to be used as bio-excipient in formulation of nanosized Topiramate loaded bio-flexy films for epilepsy treatment. Method: Formulations containing nanosized Topiramate: Arachis hypogea biopolymer (in ratios of 1:0.5, 1:1; 1:3, 1:5, 1:6, 1:10) (FAO1-FAO6) were prepared by solvent casting method. Results: Arachis Hypogea Biopolymer showed percentage yield of 20% ±0.01. The biopolymer was brown in color, odourless, partially soluble in water. Its colour changing point was found to be 210ºC±2. It was tested positive for proteins and carbohydrates, amino acids were not present. Evaluation parameters of nanosized Topiramate loaded bio-flexy films containing Arachis hypogea biopolymer (FAO1-FAO6) revealed Thickness: 0.022 mm±0.004 to 0.044±0.003 mm, Folding Endurance: 140-169, Surface pH: 7.01±0.03 to 7.01±0.02, Weight Uniformity: 0.006±0.04 to 0.036±0.02, Drug Content Uniformity: 85.4%±0.68 to 93.4%±0.50, Swelling Percentage: 73%±0.6 to 89%±0.4, Percentage Moisture Uptake (PTU): 1.8%±0.10 to 2.4%±0.08, Mucoadhesion time: 45-150 minutes, Mucoretention time: 75-210 minutes. The drug release pattern for formulations FAO1-FAO6 containing Arachis hypogea biopolymer based on the T50% and T80% was found to be FAO2 (1:1) > FAO5 (1:6) > FAO6 (1:10) > FAO1 (1:0.5)> FAO4 (1:5) > FAO3 (1:3). Conclusion: Based on all above-mentioned evaluation parameters, FAO2 (containing Topiramate: Arachis hypogea biopolymer (1:1)) Bio-flexy film having R2 =0.9215, Higuchi Matrix as best fit model, follows Fickian Diffusion (Higuchi Matrix) release mechanism, T50%: 44.52 hrs., T80%: 46.14 hrs. using BITS Software. Stability study revealed stable formulations. Isolated Arachis hypogea biopolymer showed in-built filmability, mucoadhesivity properties, was non-reactive and suitable for Soft Palatal Drug Delivery.
Nanotechnology and Treatment of Covid-19
Authors:   Department of Chemistry, Faculty of Natural Sciences, University of Guyana, Turkeyen Campus, South America, RC Jagessar
Published: February 2022

Nanotechnology has indeed fulfill many roles in many fields in contemporary science, such as electronic and IT applications, medical and health care applications, including COVID-19, Energy applications, environmental remediation, nanocomposites, herbal nano-particles. Research in this field needs to further proliferate, because of the novel properties of nano-based materials. Nanotechnology, will continue to solve many technologically driven process in contemporary science. It remains the vision of contemporary nanotechnologist to proliferate this research to other dimensions such as finding a cure for COVID-19. Nanotechnology/nanoparticles is the way forward to neutralize and eradicate SARS-COV-2 virus. Nanoparticles are of the same dimension as the SARS-COV-2 virus and thus this will promote effective interaction with the virus. Research in this area is continually increasing. In addition, a relatively large number of nanomolecules can be in effective contact with the virus of nanodimensions. Of greater significance, the use of plant extracts in synthesis of plant based nanoparticles to eradicate the viruses because of their easier synthesis, environmentally friendly nature and superior nature, as selective plants possess antiviral activities on their own.
Improved Performance of MoS2 FETs using AlN/Al2 O3 dielectric and Plasma Enhanced Atomic Layer Deposition (PEALD)
Authors:   International College of Semiconductor Technology, National Yang Ming Chiao Tung University, 1001 University Road, Hsinchu 30010, Taiwan (ROC), Lee Tsu-Ting , Chang Edward Yi ,   Institute of Microengineering and Nanoelectronics (IMEN), University of Kebangsaan Malaysia 43600 Bangi, Selangor, Malaysia
Published: February 2022

Molybdenum disulfide (MoS2 ) transistors are emerging as an exciting material system for future electronics due to their unique electrical properties, twodimensional (2D) nature and atomically thin geometry. This ultra-thin-body (UTB) semiconductor considerably reduces current leakage and enables gate-to-channel control. The homogeneous growth of sub-10 nm dielectrics on 2D materials remains challenging. We demonstrate high-performance MoS2 FETs at low temperature (150°C) using the plasma-enhanced Atomic layer deposition (PEALD) technique. The device exhibits a high on/off current ratio of about 106 , the field-effect mobility of 9.5 cm2 /Vs, and a subthreshold swing (SS) of 171 mV/dec, which is comparable to the similar structure of the top gate device. In addition, we have demonstrated contact resistance on back-gate MoS2 FETs with and without dielectric capping
Determinants of depression among undergraduate medical students of a private medical college in Lahore
Authors: Uzma Zafar  , Seema Daud  , Attiqa Khalid
Published: February 2022

Objective: To assess the prevalence and determinants of depression in undergraduate medical students within their learning environment.

Methods: The descriptive cross-sectional study was conducted at the Lahore Medical and Dental College, Lahore, Pakistan, from May to June 2015, and comprised medical students of all the five professional years. A structured questionnaire was used to collect data. Section one of the questionnaire related to demographic information, section two comprised Patient health questionnaire-9 for screening depression, and section three was the Dundee ready education environment measure inventory to gather students' perceptions of their learning environment. Data was analysed using SPSS 22.

Results: Of the 533 students, 206(39%) were males, 327(61%) were females, 213(40%) were of preclinical years and 320(60%) were of clinical academic years. Overall, 399(75%) students were found to be depressed. Of them, 255(64%) were females and 144(36%) were males. Among the students, 96(18%) had negative perception of their learning environment, and out of these, 91(95%) were found to be depressed. There was significant association of depression with female gender (p=0.037) and negative perception of the students of their learning climate (p<0.001).

Conclusion: The prevalence of depression was found to be high among the medical students and it was associated with female gender and negative perception of the learning environment.

Keywords: Patient health questionnaire-9, Depressive symptoms, Environmental determinants, DREEM inventory
Vers une autre anthropologie de la prière
Authors: Mathys Chloé
Published: February 2022

Cet article propose le repérage et l’analyse de trois manières distinctes de conceptualiser la prière dans les travaux de sciences humaines et sociales qui la prennent pour objet à compter de la publication de l’essai de Marcel Mauss (1909). Ces trois conceptualisations de prière mises en débat dès le XXe siècle sont déterminées par une variation des stratégies discursives et des rapports au théologico-religieux. Normalisée, la prière est définie selon sa forme jugée idéale. Enchantée, elle est mise au service des théories de l’homo religiosus. Désenchantée, elle est ramenée à une construction socio-psychologique. En relevant les intérêts comme les limites analytiques de chacune de ces options théoriques, l’objectif est de faire apparaître leur complémentarité afin d’esquisser les traits d’une nouvelle manière possible d’étudier la prière.
D’un relationnel personnel au cœur du théologique
Authors: Gisel Pierre
Published: February 2022

L’article part du contemporain et de ce qui en affecte le religieux, un effondrement des médiations sociales et la montée de religiosités privées vivant d’un rapport direct à la vérité. Il reprend ensuite certains des motifs en cause, décalant les oppositions reçues. Ainsi sur les médiations, à repenser en lien à ce que sont tant le religieux que le social, sur l’extériorité, à repenser en lien à ce qu’est le sujet, sur ce qu’est une tradition, à repenser comme cristallisation culturelle et institutionnelle d’une voie d’accomplissement de l’humain, à investir et valider comme telle, hors système auto-référencié. L’article fait enfin retour sur ce qu’il en est du christianisme, dans sa consistance propre, en principe faite d’une suite d’acculturations au creux des sociétés et des cultures, et vivant d’instances diverses et irréductibles. L’article y reprend le motif de l’expérience dite religieuse et en rapport à ce qui peut être une transcendance, mais cristallisée en corps à corps avec le monde et ce qui s’en éprouve et s’en dit, une expérience alors féconde, mais ainsi seulement.
Passer de l’expression à l’inapprobriable
Authors: Constantinescu Stefan
Published: February 2022

Dans le Sermon 74 sur le Cantique des Cantiques, Bernard de Clairvaux fait part de son expérience, exprimée en termes de « visites du Verbe ». De son propre aveu, il vise le dévoilement d’une ontologie de la personne qui se réalise pleinement par l’expérience immédiate du Verbe. La construction de la théologie bernardine est reprise dans cet article à partir du mouvement alternatif entre expérience et expression. La capacité humaine de produire de nouvelles formes de langage ne s’épuise pas dans la mise en œuvre de la langue. Pour mettre en exergue cette idée, les termes d’inoperosità (désœuvrement) et d’inappropriable, forgés par Giorgio Agamben, sont utilisés pour montrer dans quelle mesure le cistercien emploie l’art des paroles pour produire l’effet de son expérience personnelle avec Dieu. L’article tente ainsi de montrer que les mots bernardins entrent dans un mode de désœuvrement, afin de nous introduire dans la contemplation du Verbe en tant que forme de vie et transformation intérieure.
Pandemide öğretmen olmak: sınıf öğretmenlerinin uzaktan eğitim deneyimleri
Authors: UZUN Selda , UZUNÖZ Abdulkadir
Published: February 2022

Pandemi süreciyle birlikte eğitim-öğretim sistemimizin gündemi haline gelen uzaktan eğitimin önemi ve uygulanması tüm dünyada artarak devam etmektedir. Salgın, uzaktan eğitimin sunduğu bazı fırsatları da görme şansı vermiştir. Kısıtlamaların zorunlu olduğu benzer durumlarda, eğitim-öğretimin aksamasının önüne geçecek bir alternatif olarak görülmesi dışında önümüzdeki yıllarda yüz yüze eğitimle birlikte uygulanarak kalıcı olması beklenmektedir. Bu nedenle pandemi sürecinde uygulanan uzaktan eğitimin değerlendirilmesi, kalitesi ve verimliliğin ortaya konulması, eksikliklerin giderilmesi açısından öğretmen deneyimleri önem arz etmektedir. Buradan yola çıkarak çalışmanın amacı Covid 19 pandemisi sürecinde sınıf öğretmenlerinin uzaktan eğitim deneyimlerini ortaya koymaktır. Çalışmada nitel araştırma yöntemlerinden görüngübilim (fenomenoloji) deseni kullanılmıştır. Çalışma grubu olarak Konya ili Meram ilçesindeki bir devlet okulunda çalışan 15 sınıf öğretmeni belirlenmiştir. Katılımcıların belirlenmesinde amaçlı örnekleme yöntemlerinden ölçüt örnekleme yöntemi kullanılmıştır. Veri toplama aracı olarak araştırmacı tarafından geliştirilen yarı yapılandırılmış görüşme formu kullanılmıştır. Görüşmeler online platformda görüntülü olarak yapılmıştır. Verilerin analizinde içerik analizi kullanılmıştır. Çalışma sonuçlarına göre Sınıf öğretmenlerinin pandemi sürecinde deneyimledikleri uzaktan eğitime genel anlamda olumlu baktıkları görülmüştür. Öğretim ortamlarına yönelik olarak teknolojik fırsatlar, içeriğin zenginliği, esneklik, devamlılık, sorumluluk alma, uygulanabilirlik, veli desteği, verim ve konfor gibi olumlu deneyimler dışında teknik sorunlar, ulaşılabilirlik, sınıf yönetimi zorluğu, akran eğitiminin eksik kalması, uygulamalı derslerin zorluğu, öğrenci sağlığını olumsuz etkilemesi, sosyalliği azaltması şeklinde problemler belirlenmiştir. Ölçme değerlendirme uygulamalarını yetersiz buldukları, daha çok bireysel değerlendirmeleri tercih ettikleri tespit edilmiştir. İletişim ve etkileşime yönelik olarak görüntülü sınıf ortamı, sosyal medya, ulaşılabilirlik olumlu deneyimler olarak yer alırken, teknik sorunlar, ortamdan kaynaklı sıkıntılar, derslere giremeyen öğrenciler iletişim ve etkileşim problemleri olarak tespit edilmiştir. Mesleki yeterliliğe yönelik sonuçlar ise teknolojiye uyum, özgüven artışı, yenilikçi bakış, kendini başarılı bulma şeklinde belirlenmiştir.
GAMBARAN TINGKAT KECEMASAN PADA PASIEN STROKE DI RUANG BELIBIS RSUD WANGAYA DENPASAR
Authors: Ketut Saputra Dewa , Sri Muryani Ni Made , Sukarja I Made , Krisnayani Ni Made Wina
Published: February 2022

Background: Stroke is a major cause of disability in adults, where four million Americans experience neurological deficits due to stroke, two-thirds of these deficits are moderate to severe. This disease has become a worldwide health problem and is increasingly important, with two-thirds of strokes now occurring in developing countries. Stroke sufferers themselves will experience a psychological response, namely anxiety because in addition to being a life threat, patients will feel anxious about their future. The purpose of this study was to determine the description of the level of anxiety in stroke patients in the Belibis Room of Wangaya Hospital Denpasar. Methode: The type of design used is descriptive design. Data collection was carried out by the researchers themselves using a standard questionnaire sheet, the Hamilton Anxiety Rating Scale (HARS), with the number of respondents 30 people who were Stroke patients in the Belibis room of Wangaya Hospital Denpasar. Result: The results of this study indicate that the majority of stroke patients in the Belibis room of Wangaya Hospital Denpasar experienced moderate anxiety, namely as many as 17 (56.7%) respondents, mild anxiety as many as 6 (20%) respondents, severe anxiety as many as 6 (20%) respondents, panic 0%, and only 1 (3.3%) respondents who did not experience anxiety. Conclusion: Individuals who experience anxiety are mostly aged over 50 years, female sex, high school education, and have private jobs. It is expected that families can provide motivation and positive encouragement to patients.
FAKTOR - FAKTOR YANG BERHUBUNGAN DENGAN TERJADINYA HIPERTENSI PADA LANSIA DI PUSKESMAS III DENPASAR UTARA TAHUN 2012
Authors: Wulandari Ratna , Putra Kadek Agus Dwija , Sandi I Wayan
Published: February 2022

Background: The prevalence of isolated systolic hypertension (HST) is expected to occur approximately 25% in the age group of 60-90 years, and found as much as 59.1% in males and 61.9% in females. This research aims to determine the factors related to the incidence of hypertension in the elderly. Methods: This study uses a descriptive analytical design with the Cross Sectional approach. The research samples used are seniors aged ? 60 years and older with Consecutive Sampling technique in the working area of Puskesmas III North Denpasar. Data retrieval takes place from April to May 2012 by filling out questionnaires, measuring weight, height and blood pressure. The Data obtained is analyzed univariate and bivariate using Chi-Square test. Results: Based on the analysis gained that the factors associated with the occurrence of hypertension in the elderly are The age factor (OR: 10,833; 95% CI: 1,961-59,834), Gender factor (OR: 7,467; 95% CI: 1,400-39,837), Genetic factor (OR: 10,083; 95% CI: 1,658-61,330), Activity factors (OR: 0,095; 95% CI: 0,017-0,529), and the habit of drinking coffee (OR: 15,556; 95% CI: 2,586-93,571). Conclusion: Age, gender, genetic, activity and coffee habits are factors related to hypertension in the elderly. Expected parties are more promoting health programs in the elderly, especially on hypertensive diseases Keywords: hypertension; elderly; activities; drinking coffee
ANALISIS PEMBIAYAAN PENCEGAHAN STUNTING DI KABUPATEN BADUNGDENGAN PENDEKATAN DISTRICT HEALTH ACCOUNT
Authors: Sugianto Made Agus , Rumiati I Gusti Ayu Ngurah Lita
Published: February 2022

Background: Stunting rates in Badung Regency show an upward trend while information on funding and utilization and who is the beneficiary is still very limited. Therefore, through the District Health Account, it is expected that decision makers will be able to overcome the problem of adequacy, equity, efficiency, effectiveness and sustainability. Objective: to analyze the cost of stunting prevention using the District Health Account Approach. Method: This research is descriptive using cross-sectional studies, data collection through in-depth interviews to the manager of the District Health Office in Bandung District and the manager of the Provincial Health Department of Bali Nutrition and documentation studies. Results: Most stunting prevention costs came from the central government (70.16%), and the highest proportion of the budget was managed by puskesmas (56.74%). Most of the stunting prevention funding was used for operational expenditure (79.43%), and the financing was mainly directed towards all age groups (48.53%). In the lowest 40% (poor families) the average monthly expenditure is only Rp.438,944 or equivalent to 1,962.55 Kcal per person per day, this figure is below the stipulated calorie adequacy rate of 2,200 - 2,500 Kcal per person per day. Conclusion: The cost of stunting prevention program is only sourced from the government, where most costs come from the central government (70.16%), far exceeding the Badung Regency Government (21.16%) and the Provincial Government of Bali (8.69%). The cost of puskesmas stunting prevention program is used for operational expenses for the bottom 40% (poor families) whose average monthly expenditure is only equivalent to consuming 1,962.55 Kcal of food per person per day. Badung Regency Government to increase the financing of stunting prevention which is prioritized for the lowest 40% population (poor population). Keywords: Stunting; Financing; Badung Regency