bluuebunny/crossref_metadata_2025 huggingface dataset:
Holistic Care in the Us Military I—-The Epidaurus Project: An Initiative in Holistic Medicine for the Military Health System, 2001—2012
Authors: Foote Frederick O. , Bulger Roger J. , Frampton Susan B. , Pellegrino Edmund D.
Published: August 2012

This article describes the history and findings of the Epidaurus Project, a Uniformed Services University—affiliated project to bring holistic care and evidence-based design into the Military Health System (MHS). A distinguished group of civilian thought leaders contributed. The 2005 Base Realignment and Closure process offered a chance to implement the Epidaurus agenda. A new integrated healthcare delivery system, centered around the Walter Reed National Military Medical Center at Bethesda, Maryland, was the result. These facilities will be templates for a new generation of MHS “healing environments” and a model for innovative systems of healthcare nationwide. The Epidaurus Project represents a significant collaboration between civilian medicine and the military in times of war.
Uniformly Porous MgTi2O5 with Narrow Pore‐Size Distribution: XAFS Study, Improved In Situ Synthesis, and New In Situ Surface Coating
Authors: Suzuki Yoshikazu , Suzuki Tohru S. , Shinoda Yutaka , Yoshida Katsumi
Published: August 2012

Porous MgTi2O5 ceramics with pseudobrookite‐type structure have been prepared by in situ processing (viz. reactive sintering). In this communication, further studies have been carried out in order to evolve the porous MgTi2O5, viz., (1) X‐ray absorption fine structure (XAFS) study of porous MgTi2O5, (2) improved in situ synthesis (i.e., more precise stoichiometric control), and (3) new “in situ surface coating,” which enables in situ MgTi2O5 synthesis, in situ uniform pore formation, and in situ surface coating in only one‐step heating.
Gd3+‐Ion‐Doped Upconversion Nanoprobes: Relaxivity Mechanism Probing and Sensitivity Optimization
Authors: Chen Feng , Bu Wenbo , Zhang Shengjian , Liu Jianan , Fan Wenpei , Zhou Liangping , Peng Weijun , Shi Jianlin
Published: August 2012

Paramagnetic gadolinium (Gd‐III)‐ion‐doped upconversion nanoparticles (UCNPs) are attractive optical‐magnetic molecule imaging probes and are a highly promising nanoplatform for future theranostic nanomedicine design. However, the related relaxivity mechanism of this contrast agent is still not well understood and no significant breakthrough in relaxivity enhancement has been achieved. Here, the origin and optimization of both the longitudinal (r1) and transverse (r2) relaxivities are investigated using models of water soluble core@shell structured Gd3+‐doped UCNPs. The longitudinal relaxivity enhancement of the nanoprobe is demonstrated to be co‐contributed by inner‐and outer‐sphere mechanisms for ligand‐free probes, and mainly by outer‐sphere mechanism for silica‐shielded probes. The origin of the transverse relaxivity is inferred to be mainly from an outer‐sphere mechanism regardless of surface‐coating, but with the r2 values highly related to the surface‐state. Key factors that influence the observed relaxivities and r2/r1 ratios are investigated in detail and found to be dependent on the thickness of the NaGdF4 interlayer and the related surface modifications. A two orders of magnitude (105‐fold) enhancement in r1 relaxivity and 18‐fold smaller r2/r1 ratio compared to the first reported values are achieved, providing a new perspective for magnetic resonance (MR) sensitivity optimization and multimodality biological imaging using Gd3+‐doped UCNPs.
Composite Dissolving Microneedles for Coordinated Control of Antigen and Adjuvant Delivery Kinetics in Transcutaneous Vaccination
Authors: DeMuth Peter C. , Garcia‐Beltran Wilfredo F. , Ai‐Ling Michelle Lim , Hammond Paula T. , Irvine Darrell J.
Published: August 2012

Transcutaneous administration has the potential to improve therapeutics delivery, providing an approach that is safer and more convenient than traditional alternatives, while offering the opportunity for improved therapeutic efficacy through sustained/controlled drug release. To this end, a microneedle materials platform is demonstrated for rapid implantation of controlled‐release polymer depots into the cutaneous tissue. Arrays of microneedles composed of drug‐loaded poly(lactide‐co‐glycolide) (PLGA) microparticles or solid PLGA tips are prepared with a supporting and rapidly water‐soluble poly(acrylic acid) (PAA) matrix. Upon application of microneedle patches to the skin of mice, the microneedles perforate the stratum corneum and epidermis. Penetration of the outer skin layers is followed by rapid dissolution of the PAA binder on contact with the interstitial fluid of the epidermis, implanting the microparticles or solid polymer microneedles in the tissue, which are retained following patch removal. These polymer depots remain in the skin for weeks following application and sustain the release of encapsulated cargos for systemic delivery. To show the utility of this approach the ability of these composite microneedle arrays to deliver a subunit vaccine formulation is demonstrated. In comparison to traditional needle‐based vaccination, microneedle delivery gives improved cellular immunity and equivalent generation of serum antibodies, suggesting the potential of this approach for vaccine delivery. However, the flexibility of this system should allow for improved therapeutic delivery in a variety of diverse contexts.
Alcohol Dehydrogenase‐Catalyzed Synthesis of Enantiomerically Pure δ‐Lactones as Versatile Intermediates for Natural Product Synthesis
Authors: Fischer Thomas , Pietruszka Jörg
Published: August 2012

Starting from ethyl 4‐bromobutyrate, the chemoenzymatic synthesis of 6‐vinyl‐tetrahydro‐pyran‐2‐one has been accomplished. A screening of a number of available alcohol dehydrogenases and intense optimization of reaction parameters enabled us to establish an efficient synthesis of either enantiomer of the vinyllactone with excellent enantiomeric excess (>99%). The scope of possible applications of enantiopure vinyllactones has been verified by subjection to cross‐metathesis resulting in the total synthesis of the insect pheromone (S)‐5‐hexadecanolide and the cytotoxic styryllactone goniothalamine as well as derivatives thereof.
Copper Complex of Aminoisoborneol Schiff Base Cu2(SBAIB‐d)2: An Efficient Catalyst for Direct Catalytic Asymmetric Nitroaldol (Henry) Reaction
Authors: Boobalan Ramalingam , Lee Gene‐Hsian , Chen Chinpiao
Published: August 2012

A new bifunctional copper complex of the aminoisoborneol Schiff base – Cu2(SBAIB‐d)2 – has been developed for the effective direct catalytic asymmetric Henry reaction. One mol% of this catalyst produces the expected Henry products in high yields (up to 99%) with excellent enantioselectivities (up to 98% ee). The utility of the present catalyst was also extended to the Henry reaction with nitroethane and 1‐nitropropane that furnished the corresponding products in moderate to high yields (up to 99%) with moderate to high enantioselectivities of syn (up to 98% ee) and anti (up to 98% ee) diastereomers. The highlights of this catalytic system are easy manipulation, air and moisture tolerance, the need for 1 mol% of an easily synthesizable catalyst and the high enantioselectivities achieved for a wide range of substrates.
Improved experimental method for measuring gas diffusivity through thin porous media
Authors: Unsworth Grant , Dong Lu , Li Xianguo
Published: August 2012

Gas diffusion through porous media is critical for the high current density operation of a polymer electrolyte membrane fuel cell, where the electrochemical reaction becomes rate limited by the diffusive flux of reactants. Precise knowledge of the diffusivity through various components in a fuel cell is necessary for accurate modeling and analysis. However, many experimental measurements of diffusivity in literature have high measurement uncertainty. In this study, an improvement to the accuracy of the Loschmidt cell method is presented for measuring the diffusivity through materials with a submillimeter thickness. The diffusivity through various gas diffusion layers (GDLs) is measured, and the relative differences between GDLs are explained using scanning electron microscopy and the method of standard porosimetry. The experimental results from this study and others in current literature are used to develop a generalized correlation for the diffusibility as a function of porosity in the through‐plane direction of GDLs. © 2012 American Institute of Chemical Engineers AIChE J, 59: 1409–1419, 2013
In‐line jet mixing of liquid‐pulp‐fiber suspensions: Effect of fiber properties, flow regime, and jet penetration
Authors: Yenjaichon Wisarn , Grace John R. , Lim Choon Jim , Bennington Chad P.J.
Published: August 2012

Mixing effectiveness was determined experimentally for side jet injection into pipe flow for water and pulp suspensions for a range of fiber mass concentrations (0–3.0%), mainstream velocities (0.5–5.0 m/s), and side‐stream velocities (1.0–12.7 m/s). The mixing quality was measured in cross‐sectional planes along the pipe using electrical resistance tomography and quantified by a modified mixing index, derived from the coefficient of variation of conductivity. Mixing depended strongly on the flow regime and jet penetration. For turbulent flow, the criteria for in‐line jet mixing in water are applicable to the mixing in suspensions, with small differences likely due to differences in fiber network strength and influences of fiber‐turbulence interactions in modifying turbulent structures in the bulk. When a suspension flows as a plug, however, the mixing differs greatly from that in water, depending on the fiber network strength in the core of the pipe. © 2012 American Institute of Chemical Engineers AIChE J, 59: 1420–1430, 2013
Surface plasmon‐enhanced molecular fluorescence induced by gold nanostructures
Authors: Teng Y. , Ueno K. , Shi X. , Aoyo D. , Qiu J. , Misawa H.
Published: August 2012

The authors report on surface plasmon‐enhanced fluorescence of Eosin Y molecules induced by gold nanostructures. Al2O3 films deposited by atomic layer deposition with sub‐nanometer resolution were used as the spacer layer to control the distance between molecules and the gold surface. As the thickness of the Al2O3 film increased, the fluorescence intensity first increased and then decreased. The highest enhancement factor is achieved with a 1 nm Al2O3 film. However, the trend for the fluorescence lifetime is the opposite. It first decreased and then increased. The changes in the fluorescence quantum yield were also calculated. The yield shows a similar trend to the fluorescence intensity. The competition between the surface plasmon‐induced increase in the radiative decay rate and the gold‐induced fluorescence quenching is responsible for the observed phenomenon. In addition, this competition strongly depends on the thickness of the spacer layer between Eosin Y molecules and the gold surface.
Frontal polymerization of a cyanate ester
Authors: Viner Veronika
Published: August 2012

Thermal frontal polymerization is an exothermic process that uses a propagating wave to polymerize monomers via an external heat source, such as a soldering iron, to initiate front propagation. Herein, for the first time, the curing of a cyanate ester via thermal frontal polymerization is described with two different external heat sources. However, issues of bubbling due to vaporization of the amine catalyst generally resulted in incomplete frontal polymerization when a soldering iron was used as the external heat source. To counter this issue, dual‐strip polymerization systems were used, wherein the heat from the exothermic polymerization of a free‐radical system was used to initiate the frontal polymerization of a cyanate ester system with an amine catalyst. As a result, complete frontal polymerization occurred. Additionally, the effect of the width of the acrylate strip and its impact on the front temperature, initial velocity, and steady‐state velocity of the adjacent cyanate ester system were studied. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Preparation of nanostructured porous carbon composite fibers from ferrum alginate fibers
Authors: Wang Bingbing , Kong Qingshan , Quan Fengyu , Ji Quan , Xia Yanzhi
Published: August 2012

Nano‐microstructured porous carbon composite fibers (Fe2O3@C/FeO@C/Fe@C) were synthesized by the thermal decomposition of ferrum alginate fibers. The ferrum alginate fiber precursors were prepared by wet spinning, and calcined at 300–1000°C in high purity nitrogen. The resulting composite fibers consist of carbon coated Fe2O3/FeO/Fe nanoparticles and porous carbon fibers. All the prepared nanostructures were investigated using thermal gravimetry, X‐ray diffraction (XRD), Fourier transform infrared spectroscopy, transmission electron microscope (TEM), and nitrogen adsorption–desorption isotherm. The results show that there are five stages in the decomposition process of the ferrum alginate fibers. Transitions between the five stages are affected by the decomposition temperature. XRD results show that maghemite (Fe2O3), wüstite (FeO), martensite (Fe) nanoparticles were formed at 300–500°C, 600–700°C, 800–1000°C, respectively. Scanning electron microscopy and TEM results indicate that the composite fibers consist of nanoparticles and porous carbon. The diameter of the nanosized particles increased from 100 to 500 nm with increasing reaction temperature. The nitrogen adsorption–desorption results also show that the composite fibers have a micro‐ and mesoporous structure. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Preparation, characterization, antifungal activity, and mechanism of chitosan/TiO2 hybrid film against bipolaris maydis
Authors: Huang Qunzeng , Jiao Zhujin , Li Min , Qiu Dongfang , Liu Kecheng , Shi Hengzhen
Published: August 2012

A chitosan/TiO2 hybrid film, as a powerful antifungal material for controlling southern corn leaf blight, which is caused by the fungus Bipolaris maydis (B. maydis), was prepared and characterized. Its antifungal activity toward B. maydis was studied, and the experimental results indicate that it had multiple attractive antifungal properties as follows: (1) it displayed strong antifungal activity against B. maydis, with an inhibition ratio of 100% under both visible‐light irradiation and in a dark environment; (2) it exhibited a superior antifungal efficacy of 100%, even after 4 h under the irradiation of visible light; and (3) its antifungal activity included the effect of hydroxyl radicals generated by the photocatalysis of TiO2. The antifungal mechanism was attributed to the action of a large amount of positive charges on the structure of the hybrid film, which interacted with the negative charges from the cell and finally resulted in the inactivation of B. maydis. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Damage modeling of degradable polymers under bulk erosion
Authors: Tang C. Y. , Wang Z. W. , Tsui C. P. , Bai Y. F. , Gao B. , Wu H.
Published: August 2012

Unit micro‐cell models with different architectures were designed to simulate the degradation process and chemical damage behavior of degradable polymers under bulk erosion. The pores in the micro‐cell models were introduced to mimic the state of rapid water diffusion into the polymers under bulk erosion, while three different arrangements of pores were considered to investigate their effects on the degradation rate of different polymers with the same molecular weight. Different porosity levels were also used to study the degradation responses of the polymers having different molecular weights. A heat and mass transfer analogy was adopted to enable the analysis to be run on a general purpose finite element (FE) code. In the present work, a finite element software package ABAQUS incorporated with a user‐defined material subroutine was used to perform the analysis, in which a heat transfer function was utilized to simulate Fickian mass diffusion for the polymers through analogy. With the proposed method, the effects of chemical damage on the mechanical properties of the degradable polymers under bulk erosion could be predicted and the predicted trend of the mass loss of the polymers followed experimental results obtained from the open literature. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Millifluidic synthesis of polymer core‐shell micromechanical particles: Toward micromechanical resonators for acoustic metamaterials
Authors: Lukyanova L. , Séon L. , Aradian A. , Mondain‐Monval O. , Leng J. , Wunenburger R.
Published: August 2012

We present two routes of millifluidic‐based synthesis of solid core–solid shell particles with submillimeter size. These particles, which behave as mechanical resonators, are key components of targeted three‐dimensional locally resonant acoustic metamaterials working in the ultrasonic frequency range. The first route involves the encapsulation of a solid core into a liquid shell, which is then in‐line solidified through gelation. The second route involves two successive coflows followed by two solidifications triggered by UV irradiation and complexation, respectively. Original solutions to several practical issues are presented. The advantages and drawbacks of both routes are analyzed in the light of the targeted specifications of the resonators. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Nanocomposites of ethylene vinyl alcohol copolymer with thermally resistant cellulose nanowhiskers by melt compounding (I): Morphology and thermal properties
Authors: Martínez‐Sanz Marta , Lopez‐Rubio Amparo , Lagaron Jose M.
Published: August 2012

In this study, ethylene‐vinyl alcohol copolymer (EVOH) nanocomposites were prepared by melt compounding both plant cellulose nanowhiskers (CNW) and bacterial cellulose nanowhiskers (BCNW) as nanofillers. Electrospinning and a “dissolution precipitation” method were used as strategies for the incorporation of CNW in EVOH before melt compounding with the aim of enhancing the degree of dispersion of the nanocrystals when compared with direct melt‐mixing of the freeze‐dried product with the polymer. As revealed by morphological characterization, the proposed preincorporation methods led to a significant improvement in the dispersion of the nanofiller in the final nanocomposite films. Furthermore, it was possible to incorporate concentrations as high as 4 wt % BCNW without causing significant agglomeration of the nanofiller, whereas increasing the CNW concentration up to 3 wt % induced agglomeration. Finally, DSC studies indicated that the crystalline content was significantly reduced when the incorporation method led to a poor dispersion of the nanocrystals, whereas high‐nanofiller dispersion resulted in thermal properties similar to those of the neat EVOH. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Elongational flow mixing for manufacturing of graphite nanoplatelet/polystyrene composites
Authors: Oxfall Henrik , Rondin Jérôme , Bouquey Michel , Muller René , Rigdahl Mikael , Rychwalski Rodney W.
Published: August 2012

Manufacturing strategy is of prime importance for the appropriate incorporation of filler into a polymeric matrix, and this in particular refers to nanofillers. Herein, direct‐graphite nanoplatelets are used as filler in polystyrene. The as‐received filler material contained microscopic size agglomerates formed by nanoscopic size graphite nanoplatelets. Refining of the microagglomerates (break‐up) and production of, desirably, single graphene layers (exfoliation) is the ultimate target for controlling production and thus properties of the present materials. Several processing methods including microcompounding, roll‐milling/calendering, Brabender mixing chamber, and solvent processing are used and compared with elongational flow mixing by a newly developed mixer. For the present system, sonication with surfactant assistance solvent processing yields both good micro deagglomeration and production of thin graphene nanostacks/layers. Also the elongational flow mixing efficiently refines the microagglomerates. Solvent processing and microcompounding are more efficient than the other processes in the production of exfoliated thin graphene stacks/layers. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Benzo[1,2‐d:4,5‐d′]bisimidazoles as a Convenient Platform Towards Dyes that are Capable of Excited‐State Intramolecular Proton Transfer and of Two‐Photon Absorption
Authors: Tasior Mariusz , Hugues Vincent , Blanchard‐Desce Mireille , Gryko Daniel T.
Published: August 2012

New, strongly fluorescent benzo[1,2‐d:4,5‐d′]bisimidazoles have been prepared by the reaction of Bandrowski′s base with various aldehydes. Their structures were carefully designed to achieve efficient excited‐state intramolecular proton transfer and good two‐photon‐absorption (2PA) cross‐sections. Functional dyes that possessed both high fluorescence quantum yields and large Stokes shifts were prepared. A π‐expanded D‐A‐D derivative that possessed Φfl=50 % and σ2=230 GM in the spectroscopic area of interest for biological imaging is an excellent candidate as a fluorescent probe. Thanks to the presence of two reactive amino groups, such compounds can be easily transformed into probes for bioconjugation. All of these benzo[1,2‐d:4,5‐d′]bisimidazoles were also strongly fluorescent in the solid state.
Interior‐Point Method to Optimize Tire Force Allocation in 4‐Wheeled Vehicles Using High‐Level Sliding Mode Control with Adaptive Gain
Authors: Tavasoli Ali , Naraghi Mahyar
Published: August 2012

Nonlinear vehicle control allocation is achieved by distributing the control task to tire forces with nonlinear saturation constraints. The overall vehicle control is accomplished by developing a hierarchical scheme. First, a high‐level sliding mode control with adaptive gain is considered to obtain the body force/moment for stable vehicle motion. The proposed controller only requires online adaptation of control gains without acquiring the knowledge of upper‐bounds on system uncertainties. Then, optimal distribution of tire forces (ODF) with nonlinear saturation constraints is considered. The high‐level control objectives are mapped to individual tire forces by formulating a nonlinear optimization problem. The interior‐point (IP) method is adopted for a nonlinear programming task at each time step. Evaluation of the overall system is accomplished by simulation testing with a nine‐degrees‐of‐freedom vehicle nonlinear model. Comparison with a well‐recognized control system shows the effect of saturation constrained ODF (SCODF) on improving vehicle handling and stability.
Clinical profile and outcome of patients with severe aortic stenosis at high surgical risk: Single‐center prospective evaluation according to treatment assignment
Authors: Dvir Danny , Sagie Alexander , Porat Eyal , Assali Abid , Shapira Yaron , Vaknin‐Assa Hana , Shafir Gideon , Bental Tamir , Nevzorov Roman , Battler Alexander , Kornowski Ran
Published: August 2012

Background

The study sought to assess the clinical profile, outcome, and predictors for mortality of “real‐world” high‐risk severe aortic stenosis patients according to the mode of treatment assigned.

Methods

Patients were referred to a dedicated clinic for meticulous screening and multidisciplinary team assessment and 343 were finally assigned treatment (age 81.3 ± 7.2 years, 42.3% men): transcatheter aortic valve replacement (TAVR) with the Edwards SAPIEN or CoreValve device, 100 (29.2%); surgical aortic valve replacement (SAVR), 61 (17.8%); balloon valvuloplasty (as definitive therapy), 27 (7.9%); medication only, 155 (45.2%). No patient was lost to follow‐up.

Results

The balloon valvuloplasty group had a significantly higher 1‐month mortality rate (18.5%) than the TAVR group (3%, P = 0.006) and medical therapy group (3.9%; P = 0.004), without significant difference from the SAVR group (11.5%, P = 0.5). One‐year cumulative survival was significantly higher in the TAVR group (92%) than in the other groups (SAVR 71%, balloon valvuloplasty 61.5%, medication 65%; all P < 0.001). Among survivors, 1‐year rates of high functional class (NYHA I/II) were as follows: TAVR, 84.6%; SAVR, 63.3%; balloon valvuloplasty, 18.2%; medication, 21.4% (TAVR vs. SAVR, P = 0.04; SAVR vs. balloon valvuloplasty or medical therapy, P = 0.01). On multivariate regression analysis, renal failure (hazard ratio [HR] = 5.3, P < 0.001), not performing TAVR (HR = 4.9, P < 0.001), and pulmonary pressure (10 mm Hg, HR = 1.2, P = 0.02) were independent predictors of 1‐year mortality.

Conclusions

TAVR, performed in carefully selected high‐risk patients, is associated with an excellent survival rate and high functional class. Patients treated with another of the available modalities, including SAVR, had a worse outcome, regardless of which alternative treatment they receive. © 2012 Wiley Periodicals, Inc.
Methods of studies on quantitative structure–activity relationships for chiral compounds
Authors: Zhang Qing‐You , Xu Li‐Zhuang , Li Jing‐Ya , Zhang Dan‐Dan , Long Hai‐Lin , Leng Ji‐Yan , Xu Lu
Published: August 2012

Chiral compounds are very important in drug development, organic synthesis, materials science, toxicology, or environmental chemistry. Therefore, for creating new drugs, several methods have been suggested in recent years. In several laboratories in the world, some new methods for the derivations of the parameters were constructed and used for studies on quantitative structure–activity/property relationships of chiral molecules. The algorithms reviewed in this paper involve Zargeb group chiral indices, chiral molecular connectivity index, chiral topological charge index, chiral Am index, chiral indices based on the matrixes, chiral indices based on chiral product, conformation‐independent chirality code, conformation‐dependent chirality code, quantitative two‐dimensional chirality degrees of benzenoids, and so on. Copyright © 2012 John Wiley & Sons, Ltd.
ChemInform Abstract: Order/Disorder in YbNi1.+‐.xGa2.+‐. x (x ≤ 0.08): Crystal Structure, Thermal Expansion and Magnetic Properties.
Authors: Vasylechko L. , Burkhardt U. , Schnelle W. , Borrmann H. , Haarmann F. , Senyshyn A. , Trots D. , Hiebl K. , Grin Yu.
Published: August 2012

The title compound (‐0.08 ≤ x ≤ 0.08) is characterized by powder and single crystal XRD, neutron diffraction, XAS, NMR spectroscopy, magnetic measurements, and TB‐LMTO‐ASA band structure calculations.
ChemInform Abstract: Synthesis, Crystal Chemistry, and Magnetic Properties of RE7Li8Ge10 and Ln11Li12Ge16 (Ln: La—Nd, Sm): New Members of the [LnGe2]n[LnLi2Ge]m Homologous Series.
Authors: Guo Sheng‐Ping , You Tae‐Soo , Jung Ya‐Ho , Bobev Svilen
Published: August 2012

The title compounds are prepared from stoichiometric mixtures of the elements (Nb tubes, 1223—1273 K, 5 h) and characterized by powder and single crystal XRD, magnetic measurements, and TB‐LMTO‐ASA calculations.
ChemInform Abstract: Syntheses, Structures, Optical and Magnetic Properties of Ba2MLnSe5 (M: Ga, In; Ln: Y, Nd, Sm, Gd, Dy, Er).
Authors: Yin Wenlong , Feng Kai , Wang Wendong , Shi Youguo , Hao Wenyu , Yao Jiyong , Wu Yicheng
Published: August 2012

The new title compounds are prepared from mixtures of BaSe, Ga2Se3 or In2Se3, Ln, and Se (1323—1373 K, 48 h) and characterized by single crystal XRD, diffuse reflectance spectroscopy, magnetic susceptibility, and second harmonic generation measurements.
ChemInform Abstract: Dipolar Antiferromagnetism and Quantum Criticality in LiErF4.
Authors: Roennow Henrik M. , et al. et al.
Published: August 2012

The magnetic order, the classical phase transition, and the transition and fluctuations about the quantum critical point of the dipolar‐coupled antiferromagnet LiErF4 are characterized by neutron scattering, specific heat, and magnetic susceptibility measurements.
ChemInform Abstract: Microwave Assisted Preparation of Eu2+‐Doped Aakermanite Ca2MgSi2O7.
Authors: Birkel Alexander , Darago Lucy E. , Morrison Alasdair , Lory Laurianne , George Nathan C. , Mikhailovsky Alexander A. , Birkel Christina S. , Seshadri Ram
Published: August 2012

The title compound is prepared by a rapid and energy efficient microwave assisted solid state reaction of stoichiometric amounts of CaCO3, MgO, SiO2, and Eu2O3 using small amounts of H3BO3 as flux (domestic microwave oven).
ChemInform Abstract: [C7H10N][In3Se5]: A Layered Selenide with Two Indium Coordination Environments.
Authors: Ewing Sarah J. , Powell Anthony V. , Vaqueiro Paz
Published: August 2012

[3,5‐Me2PyH][In3Se5] (I) is solvothermally synthesized from a mixture of In, Se, and 3,5‐dimethylpyridine (3,5‐Me2Py) in a molar ratio of 1.46:2.5:66 (autoclave, 185 °C, 10 d).
ChemInform Abstract: Quaternary Tellurides with Different Valent Ge Centers: Cs2Ge3M6Te14 (M: Ga, In).
Authors: Zhang Cheng‐Yi , Zhou Liu‐Jiang , Chen Ling
Published: August 2012

The new title compounds are synthesized by solid state reaction of Ga or In, Ge, Te, and excess CsCl acting as both Cs source and flux (sealed silica tube, 820 °C, 5 d; about 90% yield).
ChemInform Abstract: Synthesis of Cu2Mo6S8 Powders and Thin Films from Intermediate Oxides Prepared by Polymeric Precursor Method.
Authors: Boursicot S. , Bouquet V. , Peron I. , Guizouarn T. , Potel M. , Guilloux‐Viry M.
Published: August 2012

The title compound is prepared by an alternative chemical route derived from the polymeric precursor method based on the Pechini process.
ChemInform Abstract: High‐Pressure Synthesis, Crystal Structure, and Electromagnetic Properties of CdRh2O4: An Analogous Oxide of the Postspinel Mineral MgAl2O4.
Authors: Guo Yanfeng , et al. et al.
Published: August 2012

A postspinel phase of CdRh2O4 is prepared by solid state reaction of a stoichiometric mixture of CdO and Rh2O3 (Au capsule, 6 GPa, 1400 °C, 1 h).
ChemInform Abstract: Self‐Assembly of Polyoxotungstate with Tetrarhodium‐oxo Core: Synthesis, Structure and 183W NMR Studies.
Authors: Sokolov Maxim N. , Adonin Sergey A. , Abramov Pavel A. , Mainichev Dmitry A. , Zakharchuk Nina F. , Fedin Vladimir P.
Published: August 2012

The new sandwich‐type polyoxometalate Na12 [{Rh4(μ3‐O)2 (H2O)2} (H2W9O33)2] ·38H2O is synthesized hydrothermally from an aqueous solution of Rh2(OAc)4 and Na10[H2W12O42] or Na2WO4 (Parr digestion bomb, pH 5.8, 125 °C, 24 h; 90% yield).
ChemInform Abstract: Pseudoephenamine: A Practical Chiral Auxiliary for Asymmetric Synthesis.
Authors: Morales Marvin R. , Mellem Kevin T. , Myers Andrew G.
Published: August 2012

Pseudoephenamine (PEA) is introduced as a versatile chiral auxiliary and an alternative to pseudoephedrine in asymmetric synthesis.
ChemInform Abstract: Catalytic Enantioselective Conjugate Addition of Grignard Reagents to Cyclic Enones Using C1‐1,1′‐Bisisoquinoline‐Based Chiral Ligands.
Authors: Qi Gao , Judeh Zaher M. A.
Published: August 2012

A new family of highly strained bisisoquinoline ligands is tested in the asymmetric conjugate addition of Grignards reagents towards cyclic α,β‐unsaturated ketones.
ChemInform Abstract: Asymmetric Hydrovinylation of 1‐Vinylcycloalkenes. Reagent Control of Regio‐ and Stereoselectivity.
Authors: Page Jordan P. , RajanBabu T. V.
Published: August 2012

In the presence of methylalumoxane and catalytic amounts of a chiral Co(II) complex, the vinylcycloalkenes undergo a highly regio‐and enantioselective 1,4‐hydrovinylation reaction.
ChemInform Abstract: Rh2(S‐PTTL)3TPA — A Mixed‐Ligand Dirhodium(II) Catalyst for Enantioselective Reactions of α‐Alkyl‐α‐diazoesters.
Authors: Boruta David T. , Dmitrenko Olga , Yap Glenn P. A. , Fox Joseph M.
Published: August 2012

Title ligand (I) is readily prepared and its structure is determined by computational and crystallographic studies to be similar to that of the known chiral crown complex Rh2((S)‐PTTL)4.
ChemInform Abstract: Organocatalytic Asymmetric Oxy‐Michael Addition to a γ‐Hydroxy‐α,β‐Unsaturated Thioester via Hemiacetal Intermediates.
Authors: Okamura Takaaki , Asano Keisuke , Matsubara Seijiro
Published: August 2012

Michael addition of carbonyl compounds (II) towards γ‐hydroxy‐α,β‐unsaturated thioester (I) proceeds smoothly in the presence of a bifunctional Cinchona alkaloid—thiourea catalyst to afford hemiacetals (III)/(IV) with moderate diastereo‐ and high enantioselectivity.
ChemInform Abstract: Enantioselective Rh(I)‐Catalyzed Cyclization of Arylboron Compounds onto Ketones.
Authors: Low Darryl W. , Pattison Graham , Wieczysty Martin D. , Churchill Gwydion H. , Lam Hon Wai
Published: August 2012

In the presence of appropriate chiral Rh catalysts, boron compounds of type (I), (V), (VII), and (IX) undergo cyclization to afford isoquinoline, dibenzoazepine, fluorene, or benzofuran derivatives with high enantioselectivity.
ChemInform Abstract: Synthesis of Ketone from Alkyl Halide Using α‐Chloro Nitrone as Oxidizing Reagent: A New Approach.
Authors: Chakraborty Bhaskar , Sharma Prawin Kumar
Published: August 2012

Compound (IV), formed as by‐product during the oxidation of isopropyl bromide (Ia) with N‐phenyl α‐chloronitrone in low yield, can itself undergo cycloaddition reaction.
ChemInform Abstract: Synthesis of Tertiary Alkyl Amines from Terminal Alkenes: Copper‐Catalyzed Amination of Alkyl Boranes.
Authors: Rucker Richard P. , Whittaker Aaron M. , Dang Hester , Lalic Gojko
Published: August 2012

The one‐pot reaction involves the hydroboration of the alkenes, followed by a novel amination of the formed alkylboranes with O‐benzoyl hydroxylamines in the presence of a copper‐carbene catalyst to give the tertiary amines exclusively as anti‐Markovnikov products.
ChemInform Abstract: Gold(I)‐Catalyzed Stereoconvergent, Intermolecular Enantioselective Hydroamination of Allenes.
Authors: Butler Kristina L. , Tragni Michele , Widenhoefer Ross A.
Published: August 2012

The reaction of disubstituted chiral and racemic allenes with N‐unsubstituted carbamates provides N‐allylic carbamates in good yields and with high enantioselectivities.
ChemInform Abstract: Cross‐Coupling of Aryllithiums with Aryl and Vinyl Halides in Flow Microreactors.
Authors: Nagaki Aiichiro , Moriwaki Yuya , Haraki Suguru , Kenmoku Akira , Takabayashi Naofumi , Hayashi Atsushi , Yoshida Jun‐Ichi
Published: August 2012

The coupling of aryl bromides with vinyl bromides in a flow microreactor is best performed via Br/Li exchange of the aryl bromide with BuLi, followed by the Pd(OAc)2‐catalyzed Murahashi coupling of the lithiated arene with the vinyl bromide.
ChemInform Abstract: E/Z‐Selectivity in Ruthenium‐Mediated Cross Metathesis.
Authors: Lujan Cristina , Nolan Steven P.
Published: August 2012

A detailed investigation on the influence of the ancillary ligand on the activity of Ru/NHC indenylidene complexes in cross metathesis reactions (CM) is presented.
ChemInform Abstract: Highly Efficient Asymmetric anti‐Mannich Reactions of Carbonyl Compounds with N‐Carbamoyl Imines Catalyzed by Amino‐Thiourea Organocatalysts.
Authors: Gao Jiuzhi , Chuan Yongming , Li Jiali , Xie Fang , Peng Yungui
Published: August 2012

The designed catalyst is effectively applied to the title reaction.
ChemInform Abstract: Mild and Ligand‐Free Pd(II)‐Catalyzed Conjugate Additions to Hindered γ‐Substituted Cyclohexenones.
Authors: Jordan‐Hore James A. , Sanderson James N. , Lee Ai‐Lan
Published: August 2012

The process can also be applied to the cyclopentenone (VIIa).
ChemInform Abstract: Facile and Efficient Method for the Debromination of vic‐Dibromides to Alkenes with BiCl3/Ga System.
Authors: Yoo Byung Woo , Kim Seo Hee , Park Young Kwang
Published: August 2012

A mild and efficient method for the debromination of aromatic vic‐dibromides (I) affords a diversity of functionalized (E)‐styrene and (E)‐stilbene derivatives in high yields.
ChemInform Abstract: Copper‐Mediated Aerobic Fluoroalkylation of Arylboronic Acids with Fluoroalkyl Iodides at Room Temperature.
Authors: Qi Qingqing , Shen Qilong , Lu Long
Published: August 2012

Under optimized conditions using a stoichiometric amount of copper powder (Cu foil is equally effective), polyfluoroalkyl iodides are coupled with a variety of arylboronic acids in the absence of a ligand.
ChemInform Abstract: Selective Elemental Fluorination in Ionic Liquids.
Authors: Hirschberg M. E. , Ignat'ev N. V. , Wenda A. , Willner H.
Published: August 2012

Elemental fluorination of disulfide (I) and iodides (III) and (V) are carried out.
ChemInform Abstract: Air Oxidation of N‐Cyclopropylanilines.
Authors: Blackburn Anthony , Bowles Daniel M. , Curran Timothy T. , Kim Hui
Published: August 2012

Compounds (I) decompose to (II) and (III) even when exposed to light of the laboratory and air.
ChemInform Abstract: Direct Synthesis of Organic Azides from Alcohols Using 2‐Azido‐1,3‐dimethylimidazolinium Hexafluorophosphate.
Authors: Kitamura Mitsuru , Koga Tatsuya , Yano Masakazu , Okauchi Tatsuo
Published: August 2012

Azide transfer of the title reagent to alcohols proceeds under mild conditions which have to be slightly changed depending on the substrate.
ChemInform Abstract: Electrochemical Selective Oxidation of Aromatic Alcohols with Sodium Nitrate Mediator in Biphasic Medium at Ambient Temperature.
Authors: Christopher C. , Lawrence S. , Kulandainathan M. Anbu , Kulangiappar K. , Raja M. Easu , Xavier N. , Raja S.
Published: August 2012

The method is advantageous with regards to simple handling, reuse of the spent mediator and high selectivity.
ChemInform Abstract: Direct Asymmetric Aldol Reactions Catalyzed by L‐Proline/PEG/SiO2 Composite Catalyst.
Authors: Xu Na , Xue Dong , Liu Ling , Liu Zhao‐Tie , Lu Jian , Liu Zhong‐Wen
Published: August 2012

A composite catalyst formed from L‐proline and PEG 1000 immobilized on silica is successfully applied in the aldol reaction of p‐nitrobenzaldehyde with simple ketones.
ChemInform Abstract: A New Entry for the Oxidation of Fluoroalkyl‐Substituted Methanol Derivatives: Scope and Limitation of the Organoiodine(V) Reagent‐Catalyzed Oxidation.
Authors: Tanaka Yusuke , Ishihara Takashi , Konno Tsutomu
Published: August 2012

The hypervalent iodine‐catalyzed oxidation of various types of fluoroalkylated alcohols is performed and compared with other oxidation systems such as Dess‐Martin, PDC, and Swern oxidation.
ChemInform Abstract: Synthesis and Fungicidal Activity of New Fluorine‐Containing Mandelic Acid Amide Compounds.
Authors: Li Shuai , Cui Can , Wang Man‐Yi , Yu Shui‐Jing , Shi Yan‐Xia , Zhang Xiao , Li Zheng‐Ming , Zhao Wei‐Guang , Li Bao‐Ju
Published: August 2012

A series of title compounds is synthesized in which the methyl group of catecholamine is replaced by a trifluoromethyl moiety.
ChemInform Abstract: N‐Heterocyclic Carbene‐Catalyzed Aerobic Oxidative Direct Esterification of Aldehydes with Organoboronic Acids.
Authors: Meng Jing‐Jing , Gao Min , Wei Yu‐Ping , Zhang Wen‐Qin
Published: August 2012

Under optimized conditions, various arylboronic acids react with aryl/heteroaryl aldehydes to give carboxylic esters.
ChemInform Abstract: Unexpectedly Ligand‐Free Copper‐Catalyzed C—S Cross‐Coupling of Benzothiazole with Aryl Iodides in Aqueous Solution.
Authors: Feng Yi‐Si , Qi Hong‐Xia , Wang Wei‐Cheng , Liang Yu‐Feng , Xu Hua‐Jian
Published: August 2012

Treatment of benzothiazole with iodobenzenes under conditions A) produces unexpectedly 2‐aminophenyl sulfide derivatives instead of the expected 2‐arylated heterocyclic derivatives (mechanism).
ChemInform Abstract: IBX/I2‐Mediated Reaction of Sodium Arenesulfinates with Alkenes: Facile Synthesis of β‐Keto Sulfones.
Authors: Samakkanad Natthapol , Katrun Praewpan , Techajaroonjit Thanachart , Hlekhlai Sornsiri , Pohmakotr Manat , Reutrakul Vichai , Jaipetch Thaworn , Soorukram Darunee , Kuhakarn Chutima
Published: August 2012

The one‐pot procedure for a direct synthesis of the target compounds from nonactivated aliphatic alkenes or styrenes represents an important alternative to known methods.
ChemInform Abstract: Bromodimethylsulfonium Bromide (BDMS)‐Mediated Lossen Rearrangement: Synthesis of Unsymmetrical Ureas.
Authors: Yadav Deepak K. , Yadav Arvind K. , Srivastava Vishnu P. , Watal Geeta , Yadav Lal Dhar S.
Published: August 2012

BDMS serves as a safe and efficient reagent for in situ generation of isocyanates via Lossen rearrangement of hydroxamic acids.
ChemInform Abstract: Continuous Flow Processing of Gaseous Ammonia Using a Teflon AF‐2400 Tube‐in‐Tube Reactor: Synthesis of Thioureas and In‐Line Titrations.
Authors: Browne Duncan L. , O'Brien Matthew , Koos Peter , Cranwell Philippa B. , Polyzos Anastasios , Ley Steven V.
Published: August 2012

During reaction, the amount of ammonia taken up by the solvent DME is measured by a colorimetric in‐line titration technique.
ChemInform Abstract: Mild and Efficient Allylation of Indoles and Amides Using Amberlyst‐15 as a Recyclable Heterogeneous Catalyst.
Authors: Liu Zhe , Wang Dong , Wu Yanchao , Chen Yongjun
Published: August 2012

The catalyst can be recycled and reused for at least seven runs without significant loss of activity.
ChemInform Abstract: Palladium(0)‐Catalyzed Cyclization of 1,6‐Diyn‐3‐yl Carbonates with a Nucleophilic Functionality: Efficient Synthesis of Polycyclic Benzo[b]fluorene Derivatives via Allene Intermediates.
Authors: Zhu Shugao , Wu Luling , Huang Xian
Published: August 2012

A convenient sequential method for the facile and efficient synthesis of the title compounds (II) and (IV) from easily accessible starting materials is developed under mild conditions.
ChemInform Abstract: Trifluoromethyl Derivatives of C88 (33) Fullerene
Authors: Lanskikh Maria A. , Chang Kaichin , Tamm Nadezhda B. , Kemnitz Erhard , Troyanov Sergey I.
Published: August 2012

synthesis, separation, and X‐ray crystallographic analysis of C88(CF3)nderivatives (n = 16, 18, 20)
ChemInform Abstract: An Organocatalytic Michael—Aldol Cascade: Formal [3 + 2] Annulation to Construct Enantioenriched Spirocyclic Oxindole Derivatives.
Authors: Duan Shu‐Wen , Li Yang , Liu Yi‐Yin , Zou You‐Quan , Shi De‐Qing , Xiao Wen‐Jing
Published: August 2012

The presented approach provides a facile access to a new family of polyfunctionalized spirooxindoles bearing three consecutive stereogenic centers.
ChemInform Abstract: Alkylation of N‐Arylcyanamides and Electron‐Deficient Phenols with (Chloromethyl)thiirane.
Authors: Butkevich A. N. , Zibinsky M. , Sokolov V. V. , Tomashevskii A. A.
Published: August 2012

The title reaction in aqueous alkaline solutions provides a convenient access to novel thietane derivatives (III) and (VI), respectively.
ChemInform Abstract: Efficient Ce(III)‐Catalyzed cis‐Selective Synthetic Approach to γ‐Lactones in Aqueous Media.
Authors: Rai Vijai K. , Tiku Priya , Kumar Anil
Published: August 2012

A CeCl3‐catalyzed one‐pot synthesis of title compounds (III) (10 examples) becomes possible via a regioselective epoxide ring‐opening and subsequent mercaptoacetylative cyclization in water.
ChemInform Abstract: Facile and Efficient Synthesis of γ‐Lactone and Butenolide Derivatives.
Authors: Zhang Xingxian , Guo Jincai , Hu Shenghui
Published: August 2012

Baeyer—Villiger rearrangement of cyclobutanone derivatives (I) provides the corresponding γ‐lactones (II) which can be further transformed to butenolide (VIII) via δ‐lactone (III).
ChemInform Abstract: Gold‐Catalyzed Carbene Transfer to Alkynes: Access to 2,4‐Disubstituted Furans.
Authors: Kramer Soeren , Skrydstrup Troels
Published: August 2012

Carbon ylides (I) and (IV) stabilized by a carbonyl group are used as the carbene equivalent in the title reaction, which represents a formal [3 + 2] cycloaddition.
ChemInform Abstract: Organocatalytic Sequential α‐Aminoxylation and cis‐Wittig Olefination of Aldehydes: Synthesis of Enantiopure γ‐Butenolides.
Authors: Devalankar Dattatray A. , Chouthaiwale Pandurang V. , Sudalai Arumugam
Published: August 2012

A simple procedure for the synthesis of the title compounds (III) is developed from readily available starting materials.
ChemInform Abstract: Heck‐Type Coupling of Intramolecularly‐Generated Thiopalladacycles with Alkenes: One Pot Syntheses of 3‐Alkenylbenzo[b]thiophenes.
Authors: Karkhelikar Manjusha , Racharlawar Shailesh S. , Salian Subhas M. , Sridhar B. , Likhar Pravin R.
Published: August 2012

A new methodology for the synthesis of the title compounds and the seleno analogues (IX) is developed.
ChemInform Abstract: Addition of Pyrroles onto Terminal Alkynes Catalyzed by a Dinuclear Ruthenium(II) Complex.
Authors: Tan Sze Tat , Teo Yew Chin , Fan Wai Yip
Published: August 2012

Conditions are elaborated which allow the preparation of vinylpyrrole structures with a potential for further functionalization including the construction of dipyrromethane skeletons.
ChemInform Abstract: Dinuclear Zinc Catalyzed Asymmetric Spirannulation Reaction: An Umpolung Strategy for Formation of α‐Alkylated‐α‐hydroxyoxindoles.
Authors: Trost Barry M. , Hirano Keiichi
Published: August 2012

Treatment of oxindoles of type (I) with α,β‐unsaturated esters in the presence of ZnEt2 and the chiral amino alcohol results in efficient, highly diastereo‐ and enantioselective formation of spirocyclic oxindoles.
ChemInform Abstract: Synthesis of 3‐Carboxylated Indoles Through a Tandem Process Involving Cyclization of 2‐Ethynylanilines Followed by CO2 Fixation in the Absence of Transition Metal Catalysts.
Authors: Inamoto Kiyofumi , Asano Narumi , Nakamura Yuka , Yonemoto Misato , Kondo Yoshinori
Published: August 2012

The efficient approach can be extended to 3‐carboxylated benzofurans.
ChemInform Abstract: Mild and Efficient C2‐Alkenylation of Indoles with Alkynes Catalyzed by a Cobalt Complex.
Authors: Ding Zhenhua , Yoshikai Naohiko
Published: August 2012

N‐Pyrimidylindole and its derivatives substituted at the 3‐ to 7‐position are stereoselectively alkenylated using the phosphine‐pyridine bidentate ligand PEP and an optimized amount of Grignard compound NPMB to give exclusively the (E)‐alkenyl isomers.
ChemInform Abstract: A Catalytic Metal‐Free Ritter Reaction to 3‐Substituted 3‐Aminooxindoles.
Authors: Zhou Feng , Ding Miao , Zhou Jian
Published: August 2012

The simple and metal‐free title reaction is presented from easily available starting materials and by using a cheap and easily to handle catalyst.
ChemInform Abstract: Direct and Highly Enantioselective Iso‐Pictet—Spengler Reactions with α‐Ketoamides: Access to Underexplored Indole Core Structures.
Authors: Schoenherr Heike , Leighton James L.
Published: August 2012

A simple, new, and highly stereoselective approach to pyrroloisoquinoline and pyrazinoindole derivatives is reported.
ChemInform Abstract: Cycloaddition of CO2 to Epoxides Catalyzed by N‐Heterocyclic Carbene (NHC)—ZnBr2 System under Mild Conditions.
Authors: Liu Xiang , Cao Changsheng , Li Yunfei , Guan Pei , Yang Longguang , Shi Yanhui
Published: August 2012

An efficient catalytic system is developed for the fixation of carbon dioxide.
ChemInform Abstract: Organocatalytic Sequential α‐Amination/Corey—Chaykovsky Reaction of Aldehydes: A High Yield Synthesis of 4‐Hydroxypyrazolidine Derivatives.
Authors: Kumar B. Senthil , Venkataramasubramanian V. , Sudalai Arumugam
Published: August 2012

The title reaction allows a new and highly stereoselective access to the target compounds; epoxides are not obtained.
ChemInform Abstract: Enantioselective Synthesis of Dihydropyrazoles by Formal [4 + 1] Cycloaddition of in situ Derived Azoalkenes and Sulfur Ylides.
Authors: Chen Jia‐Rong , Dong Wan‐Rong , Candy Mathieu , Pan Fang‐Fang , Joerres Manuel , Bolm Carsten
Published: August 2012

The efficient and scalable title transformation is presented for the first time.
ChemInform Abstract: Pd‐Catalyzed Direct Arylation of Phenylpyrazole: Synthesis of Fipronil Derivatives with Aryl Boronic Acids Promoted by a Stoichiometric Amount of NIS.
Authors: Lv Ting , Zhang Xiao‐Hong , Han Jiang‐Sheng , Zhong Ping
Published: August 2012

N‐Iodosuccinimide promotes the generation of 4‐iodo‐1‐phenylpyrazole in situ, compared to iodine and ICI, which is subsequently reacted with phenyl boronic acid to afford the arylated product.
ChemInform Abstract: Design and Synthesis of 3‐(2‐Ethyl‐4‐{2‐ [2‐(4‐fluorophenyl)‐5‐methyloxazol‐4‐yl]ethoxy}phenyl)propanoic Acid: A Novel Triple‐Acting PPARα, ‐γ, and ‐δ Agonist.
Authors: Zhang Qijun , Sun Peng , Zheng Guojun , Wang Yaping , Wang Xiangjing , Wei Hegeng , Xiang Wensheng
Published: August 2012

The synthetic route to the title compound, involving the formation of the oxazole ring as the key step, starts from 3‐oxopentanoic acid methyl ester and 3‐hydroxyacetophenone to afford the target compound with an overall yield of 32%.