bluuebunny/crossref_metadata_2025 huggingface dataset:
MEMORY AS BELONGING: EXISTENTIAL CONCRETIZATION IN THE WORK “THE TRUTH ABOUT ME: A HIJRA LIFE STORY” BY A. REVATHI
Authors: Galdino Natália , Carvalho Rocha Ana Lilia
Published: February 2025

This work seeks to discuss the concepts of memory, resistance and belonging, through reflections on some authors such as Alfredo Bosi (1996), Augusto Sarmento-Pantoja (2022), Tânia Sarmento-Pantoja (2022) with regard to resistance; Maurice Halbwachs (1990), Michael Pollak (1992) on the concepts of memory; Sandra Regina Lestinge (2004) and Lucimara Valdambrini Moriconi (2014) on belonging, among others who corroborate the development of this work. The aim of this research is to understand relations of resistance as a way of existing and to understand the process of memory for existential realization. The corpus of this research is chapters 1, 2 and 3 of the autobiographical work “The Truth About Me: A Hijra Life Story by A. Revathi”. To develop this research, we used the method of qualitative bibliographical research based on a theoretical-critical analysis of the selected work. As a result, we witness through Revathi's narrative a resistance based on the need for survival, where we are introduced to her trajectory as a Hijra and how these memories were/are essential for existential fulfillment, in order to be who you have always been.
LITERATURAS AFRICANAS DE EXPRESSÃO EM LÍNGUA INGLESA E ALGUMAS FORMAS DE AUTOINSCRIÇÃO
Authors: De Oliveira Valeria Silva
Published: February 2025

O presente artigo objetiva apresentar algumas formas de autoinscrição de existências e subjetividades de mulheres africanas. Entre essas formas, destacam-se romances, poemas, ensaios, contos e testemunhos. Para o presente estudo, foram analisadas principalmente algumas obras da somali-britânica Nadifa Mohamed que através de romances, poemas, ensaios e contos (re)inscreve narrativas e memórias individuais e coletivas que surgem tanto a partir da terra natal quanto da diáspora. Constata-se que o trabalho de escrita de Nadifa Mohamed resulta em um corpus cujo conteúdo vai de encontro a uma histórica prática de simplificação da complexidade. Neste artigo, há também um breve estudo de alguns testemunhos apresentados na obra Somalia – the Untold Story: the war through the eyes of somali women organizados e editados por Judith Gardner e Judy El Bushra. Nessa obra, observa-se que o testemunho enquanto gênero narrativo se apresenta por meio das vozes das mulheres africanas, mais especificamente da África Oriental, das mais variadas formas, inclusive no formato de um poema. Por fim, cabe destacar que as escritas selecionadas para o presente estudo encenam múltiplos formatos de representações das vozes, trajetórias, vivências e olhares das mulheres africanas e revelam a necessidade de um olhar atento para as especificidades de cada forma de autoinscrição.
MEDO, HOMOSSOCIABILIDADE E FRUSTRAÇÃO EM FILHO NATIVO
Authors: Diniz Douglas
Published: February 2025

O presente artigo tem por objetivo apresentar uma leitura crítica da primeira parte do romance Native Son, intitulada Fear, sob a perspectiva dos estudos sobre homens negros e masculinidades. Por meio da percepção de um mundo negro e um mundo branco figurados na obra, o artigo explora três aspectos fundamentais para composição da primeira parte do romance de Richard Wright: o medo do personagem principal Bigger Thomas, que se reproduz em atos violentos aparentemente ilógicos, mas fundamentais à sua composição enquanto homem e indivíduo; a homossociabilidade de homens negros em uma Chicago segregada durante a década de 1930, como espaço para reiteração de suas masculinidades, em oposição e contradição perante uma lógica hipermasculina, violenta e disfuncional; além da frustração do protagonista, que se demonstra desiludido frente as espectativas de um mundo branco pouco receptivo em uma realidade anti-negra.
ECOFEMINISMO E RESISTÊNCIA DISCURSIVA NA POESIA DE MAYA ANGELOU
Authors: Dos Santos Esteves Natacha , Fujita Gabriela , dos Santos Coqueiro Wilma
Published: February 2025

O presente estudo, partindo da obra poética Poesia completa (2020), da autora afro-americana Maya Angelou, apresenta considerações estéticas e temáticas sobre os poemas “África” e “Minha culpa”. Ambas as poesias, que apresentam as reverberações do colonialismo, machismo e racismo, são analisadas pelo viés do ecofeminismo e da resistência discursiva. Para tanto, a metodologia utilizada é bibliográfica, centrada em pesquisas advindas dos Estudos Culturais e pós-coloniais, tendo ênfase na Crítica Feminista, partindo de autores como, Gaard e Murphy (1998), Soares (2005), Ashcroft (2001), Lorde (2019) e hooks (2019), dentre outros.
Giant epidermal cyst in the breast requiring reconstruction with the bilobed flap technique: case report
Authors: Araújo Juliana Lopes de Aguiar , Navarro Diana Taissa Sampaio Marinho , Dantas Macerly Laise de Menezes , Brunet Gabrielly de Sousa , Ferreira Larissa dos Santos Lourenço , Sousa Ubiratan Wagner de
Published: February 2025

Epidermal cysts are one of the most common benign skin lesions, originating in the pilosebaceous unit, and are very common on the scalp, back, and trunk. They usually measure from millimeters to a few centimeters and require surgical treatment only depending on the patient's discomfort. Cases that mimic breast neoplasms are rare. Treatment consists of a minimal incision, with removal of the contents and their capsule, without major complications. We report here the case of a woman with an epidermal cyst in her left breast, which had grown progressively over the years, reaching 6 cm. Because of its size, location, and unfavorable relationship between tumor size and breast size, surgery using an oncoplastic breast remodeling technique was chosen, opting for the use of a bilobed flap to achieve a satisfactory cosmetic result, without loss of breast volume.
Prevenção de agravos e tratamentos de úlceras diabéticas
Authors:   , SANTOS RODRIGO PIA DOS
Published: February 2025

A Diabetes Mellitus é caracterizada como uma síndrome metabólica de origem multifatorial, causada pela produção inadequada de insulina no pâncreas, resultando em hiperglicemia. Nesse contexto, a úlcera diabética é uma das principais complicações da doença, sendo caracterizada por infecção, ulceração e/ou perda de tecidos moles, decorrente de alterações neurológicas e da presença de doença arterial periférica nos membros inferiores. O objetivo deste estudo foi identificar as ações de prevenção de úlceras diabéticas, além de descrever as principais formas de tratamento. Trata-se de uma revisão integrativa de literatura, utilizando como fontes de dados a Biblioteca Virtual em Saúde, o Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde, a Base de Dados de Enfermagem e o Medical Literature Analysis and Retrieval System Online. A amostra final foi composta por nove artigos que atenderam ao objetivo proposto para a revisão, selecionados após leitura e análise dos títulos e resumos de 71 artigos encontrados na primeira etapa de busca e seleção. A partir da análise dos artigos, foram identificadas importantes ações realizadas pelos enfermeiros na prevenção e tratamento de úlceras diabéticas, tais como a higiene e inspeção dos pés, ações educativas em saúde e o incentivo à adesão ao tratamento medicamentoso para o controle da doença, entre outras.
Inseminação Caseira na Perspectiva da Bioética Jurídica no Brasil
Authors: Silva Karla De Mello , Cabral Hildeliza Boechat , Almeida João Carlos De Aquino
Published: February 2025

A inseminação caseira é uma nova forma de conceber, utilizada por pessoas que não conseguem engravidar de forma natural e sem condições de arcar com os custos das técnicas de reprodução medicamente assistidas. É um procedimento que não conta com amparo legal, ético ou médico, o que por consequência pode gerar inúmeros inconvenientes, como os analisados na presente obra. Dentre eles, a possibilidade de perfuração ou lesão do útero, transmissão de doenças sexuais, reconhecimento de filiação, disputas pela convivência familiar com a criança e dificuldade de registro da prole. A obra analisa a importância das redes sociais digitais para a concretização do procedimento de inseminação caseira, o crescimento do número de adeptos, os riscos à saúde da mulher e da criança fruto da concepção e os desafios
ético-jurídicos da adoção do referido procedimento. Investiga-se a possibilidade de riscos para os adeptos, ao expô-los à condição de
vulnerabilidade, pois grande é o número de pessoas que vêm utilizando o procedimento reprodutivo, apesar das peculiaridades e dos riscos tanto no aspecto médico, como no jurídico. Na seara jurídica, os efeitos nefastos já podem ser verificados nas decisões proferidas nos casos concretos. Portanto, diante das consequências, constatou-se que a inseminação caseira tem um potencial danoso para os adeptos que não pode ser desconsiderado e, em sua maioria, não cientes dos riscos e consequèncias, optam pelo procedimento. Para compreender os desdobramentos na sociedade contemporânea, o tema foi analisado ainda à luz da Bioética da Proteção e da
Intervenção.
Meninas do Rio de Ouro:
Authors: Rocha Igor de Oliveira , LIMA NARA MACIEL FALCAO , Custódio Tânia Valéria De Oliveira , Santos Andrya Dionele Pinheiro dos , Falcão Charles Maciel , Rodrigues Cristinana Nunes , Souza Daniela Gomes de , Souza Diana França de , PIRES FABRICIA DA SILVA , Lopes Graziela de Oliveira , Yamaguchi Kleinicy Kazumi de Lima , Furtado Maria Aparecida Silva , Oliveira Rayane dos Santos , Vieira Regina Coeli da Silva , Araújo Rodrigo Alves de , Coelho Tereza de Jesus de Souza , Silva Uenderson Alivad Oliveira da , Oliveira Urlânia Alves de
Published: February 2025

O eBook "Meninas do Rio de Ouro" destaca a necessidade de metodologias
participativas, como a pesquisa-ação, e da promoção da educação e formação profissional
como ferramentas para o empoderamento social e econômico dessas populações. Ao
longo de suas seções, o livro oferece uma visão abrangente sobre os desafios enfrentados
por essas comunidades e propõe soluções baseadas na integração entre conhecimento
tradicional e práticas educacionais inovadoras. Mais do que uma análise teórica, a obra
apresenta experiências concretas que demonstram o impacto positivo da educação e da
capacitação para o fortalecimento das mulheres ribeirinhas e para a construção de uma
sociedade mais justa e inclusiva.
Prevenção e Agravos e tratamentos de úlceras diabéticas
Authors: SANTOS RODRIGO PIA DOS
Published: February 2025

A Diabetes Mellitus é caracterizada como uma síndrome metabólica de origem multifatorial, causada pela produção inadequada de insulina no pâncreas, resultando em hiperglicemia. Nesse contexto, a úlcera diabética é uma das principais complicações da doença, sendo caracterizada por infecção, ulceração e/ou perda de tecidos moles, decorrente de alterações neurológicas e da presença de doença arterial periférica nos membros inferiores. O objetivo deste estudo foi identificar as ações de prevenção de úlceras diabéticas, além de descrever as principais formas de tratamento. Trata-se de uma revisão integrativa de literatura, utilizando como fontes de dados a Biblioteca Virtual em Saúde, o Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde, a Base de Dados de Enfermagem e o Medical Literature Analysis and Retrieval System Online. A amostra final foi composta por nove artigos que atenderam ao objetivo proposto para a revisão, selecionados após leitura e análise dos títulos e resumos de 71 artigos encontrados na primeira etapa de busca e seleção. A partir da análise dos artigos, foram identificadas importantes ações realizadas pelos enfermeiros na prevenção e tratamento de úlceras diabéticas, tais como a higiene e inspeção dos pés, ações educativas em saúde e o incentivo à adesão ao tratamento medicamentoso para o controle da doença, entre outras.
Reducing postgreSQL read and write latencies through optimized fillfactor and hot percentages for high-update applications
Authors: Murali Natti
Published: February 2025

In PostgreSQL, optimizing performance [1] for high-transaction, high-update applications is crucial for maintaining low latency and high throughput. One of the primary challenges faced in these environments is the default behavior of PostgreSQL, which can lead to row migration, the accumulation of dead tuples, and increased vacuum overhead due to frequent updates to the same rows. When data is updated frequently, PostgreSQL typically writes updated rows into new locations, which can result in row migration and the creation of "dead tuples" (old versions of rows that are no longer needed). This can slow down database performance because the system has to manage and clean up these dead tuples, which requires additional processing time and resources. Furthermore, PostgreSQL’s vacuum process, which is responsible for cleaning up these dead tuples, can add significant overhead, especially during peak transaction times. This paper proposes a performance-tuning strategy aimed at addressing these challenges by optimizing PostgreSQL’s fillfactor and Heap-Only Tuple (HOT) percentages. The fillfactor determines how much space is left in each data page for future updates, and by adjusting it to leave more space, we reduce the need for row migration. Additionally, by maximizing the efficiency of HOT updates—updates that allow changes to be made within the same data block rather than creating new tuples and moving them—we significantly reduce the overhead caused by dead tuples and row migration. By leveraging these two adjustments, this strategy leads to significant reductions in both read and write latencies, improving query performance and overall application responsiveness. This approach is particularly beneficial for applications with high-frequency updates, such as real-time data systems, where data is frequently modified, and transactional workloads, where consistent, low-latency performance is essential. In these environments, even small performance improvements can have a substantial impact on system efficiency and user experience. By focusing on reducing the time spent managing dead tuples and minimizing the need for row migration, PostgreSQL can be tuned to provide better performance and scalability in high-update, high-transaction settings.
AI-powered nano formulation: revolutionizing drug development and delivery
Authors: Amar Abubaker Edriss  , Sravani Yarra  , Joshua Anthony Vomo  , Kateregga Ismael  , Yassin Babkir Elshiekh
Published: February 2025

This study examines the revolutionary potential of AI-driven nanotechnology in redefining drug development and delivery systems. Nano formulations offer numerous advantages over traditional methods, including enhanced drug efficacy, targeted delivery, and reduced side effects. However, limitations like batch-to-batch variability hinder their widespread adoption. AI integration addresses these challenges by enabling data-driven design optimization, predictive modelling, and streamlined quality control in nano-formulation manufacturing processes. AI-powered algorithms can utilize large datasets to develop nanoparticles tailored for targeted drug delivery, and to foresee their interactions with biological entities. This approach can significantly accelerate the development of innovative nanomedicines and improve their clinical translation. Despite promising advancements, technical challenges related to data quality and regulatory hurdles remain. Additionally, ethical considerations regarding privacy, bias, and transparency in AI algorithms need to be addressed. The future of AI-driven nanomedicine holds exciting possibilities, such as autonomous nano formulation design and smart nanoparticles with controlled drug release. Further research focusing on advanced AI models, improved data integration, and interdisciplinary collaboration is crucial to fully realize the potential of this technology and bring us closer to achieving personalized and effective treatments.
Design and development of natural powder hand wash for skin care
Authors: Sneha Suhas Gawali  , Bhavana Dnyandeo Tambe
Published: February 2025

Hands are primary site of inspection transmission and route for micro-organisms. Hand wash is one of the types of cosmetics which is widely used in daily life. The main aim is to develop natural and effective poly-herbal hand wash. In the present research works focuses drying powder of lemon grass (Cymbopogon), Tulsi, Aloe vera, lemon peels, Reetha, Shikakai and Mentha they have antibacterial, antifungal, antiseptic agents, with the herbal ingredients developed and evaluates as herbal powder hand wash. Herbal powder hand wash was developed by using Carbopol 930 as jelling agent, methyl paraben as neutralizer, and Sodium lauryl sulphate as surfactant. The hand wash showed multipurpose effects and all these herbal ingredients significant different activities. The ingredients use in herbal powder hand wash having properties cleaning, remove dirt as well as promote healing. The prepared formulation was evaluated based on number of criteria including consistency, pH test, stability, cleaning test, foam ability and grittiness.
Low-power frequency divider in 180 nm CMOS technology for 2.4 GHz phase locked loop applications
Authors: Ezzidin Hassan Aboadla  , Ali Hassan
Published: February 2025

This paper presents the design and analysis of a low-power programmable frequency divider implemented in 180 nm CMOS technology, optimized for applications in the 2.4 GHz Bluetooth band. In the proposed architecture, a 32/33 dual-modulus prescaler, a main counter, and a swallow counter are integrated, utilizing true single-phase clock (TSPC) flip flops that enable high-speed operation with minimal power consumption. The design was simulated and evaluated using PSPICE software under a 2V supply voltage, demonstrating stable frequency division with low phase noise. Simulation results revealed a total power consumption of 0.58 mW, with efficient distribution across the prescaler and counter circuits. This work addresses key challenges in power efficiency, operational speed, and circuit area, making it a strong candidate for energy-constrained applications such as Bluetooth transceivers, wireless sensor networks, and IoT devices. With the proposed frequency divider, wireless communications systems can easily integrate PLL-based frequency synthesizers into their next-generation systems. This is a scalable, energy-efficient solution.
Safeguarding childhood: Raising awareness on the protection of children from sexual offences (POCSO) Act
Authors: Suraj Singh  , Praveena  , Sudhakar PVB  , Maruthi Krishna Goud. K
Published: February 2025

Child sexual abuse is a pervasive issue that has severe and long-lasting consequences on a child's physical, emotional, and psychological well-being. Recognizing the urgency of addressing this matter, the Government of India enacted the Protection of Children from Sexual Offences (POCSO) Act in 2012, which was later amended in 2019 to introduce stricter punishments. Despite the comprehensive legal framework, many cases of abuse remain unreported due to fear, stigma, and lack of awareness among children, parents, and communities. This paper aims to provide an in-depth analysis of the POCSO Act, highlighting its key provisions, legal amendments, and implementation challenges. By reviewing statistical data and comparing global child protection laws, this study identifies gaps in enforcement and explores how socio-cultural barriers impact reporting and justice delivery. The research also delves into the rise of digital crimes against children, the effectiveness of special courts, and the need for multi-sectoral collaboration to strengthen child protection. Additionally, the study presents evidence-based recommendations for policymakers, educators, parents, and law enforcement agencies to enhance awareness and ensure a safer environment for children. Ultimately, this paper underscores the importance of collective responsibility in eradicating child sexual abuse and ensuring justice for victims.
Solar Panel Installation Engineering for Energy Conversion Optimization in Solar Power Plants
Authors: Yandri Valdi Rizki , Mayura Yona , Wiharti Wiwik , Hendri Zulka , Hendri Lenny Novi , Mufid Ulfiah
Published: February 2025

The sunlight absorption is the main technical factor of solar power plants performance because it affects to the amount of solar energy conversion. In order to optimize this absorption, the position of solar panel should be adapted to the direction of sunlight so it can improve the economic factor of solar power plants utilization. Furthermore, in this research, we have designed and tested three serial connection solar panels with single solar tracker (SST) to optimize the absorption of sunlight and its conversion to electricity, where the electrical current from panel with SST (1.41 – 2.52 A) is higher than panel without SST (0.89 – 1.59 A). Another parameter, namely electrical power of solar power plants, is proportional to electrical current and also higher than without SST (65.2 – 102.4 W), so the stored electrical energy in battery can be also increased. The utilization of Arduino Mega 2560, driver motor BTS7960, and linear actuator can optimize the solar panel absorption and finally this control circuit addition can increase the solar energy conversion to electricity. Besides that, this control circuit will reset the position of solar panel at 6.30 pm to the starting position. It means the solar energy conversion can be maximized by using SST and this advantage can increase the efficiency and support the transition to renewable energy.
The effects of Lean and people’s behaviours on Occupational Safety
Authors: Sá José Carlos , Oliveira Ana , Hines Peter , Mourão Filipa , McDermott Olivia , Marques Pedro Alexandre , Zouari Alaeddine , Pathania Abhilash , Ulewicz Robert
Published: February 2025

Lean methodologies have been implemented in various sectors, helping to improve the overall efficiency and performance of organisations. The aim of this research is to investigate the relationship between Lean and occupational safety and its impact on people’s behaviour. To this end, a survey was developed and a statistical study carried out. The survey was sent to 4381 companies, from which 289 responses were received from 12 different countries. The Cronbach’s alpha value obtained was greater than 0.86, which indicates that the internal reliability/consistency of the results is very good. Through the statistical study it was possible to conclude that the approaches with the greatest contribution to cultural change in terms of occupational safety are 5S, Standard Work and TPM. It was also concluded that the implementation of Lean practices has a positive impact on people’s behaviour, and that these results differ depending on whether the company is located in Portugal or not. Furthermore, Lean proved to have a very positive impact on performance indicators, especially in companies located in Portugal, regardless of the sector of activity. The results also show that the contribution of Lean management to occupational safety system is very important in different sectors and is influenced by the sector of activity and by the company’s location, and that the impact of the occupational safety system on people’s behaviour was considered very important, with little influence from the company’s location and no influence from the sector of activity. This comprehensive research provides a body of knowledge that is expected to provide positive insights for Lean practitioners, managers and academics.
Analgesic Efficacy of Oral Carprofen-Treated Gel and Tablets for an Incisional Pain Model in NSG Mice
Authors: Alamaw Eden D , Tien Krystal , Zhang Mingyun , Ge Yufei , Gorman Gregory , Nagamine Claude M , Jampachaisri Katechan , Ray Ryann R , Pacharinsak Cholawat , Huss Monika K
Published: February 2025

Stress in research animals affects their welfare and alters physiologic responses, potentially impacting research outcomes. Laboratory rodents often experience stress from repeated parenteral drug administrations due to handling and needle punctures. In this study, we compared the efficacy of oral carprofen tablets and carprofen-treated nutritional gels compared with injectable carprofen for alleviation of postoperative mechanical and thermal hypersensitivity in NSG mice. Male and female mice (n = 59) were randomly assigned to one of 5 groups: 1) placebo (Placebo tablets or NutraGel, daily); 2) carprofen tablets (CarpTab; 2 mg, daily); and 3) carprofen injection (Carp25SC; 25 mg/kg SC, daily), low-dose carprofen-treated gels (CarpGel-low; 0.11 mg/mL, daily); and high-dose carprofen-treated gels (CarpGel-high; 0.22 mg/mL, daily). Mechanical and thermal hypersensitivities were assessed before surgery on D-1 and at D0 (4 h), D1, and D2 afterward. Plasma carprofen concentration (n = 56) was assessed over 1 to 4 d. Daily clinical observations, fecal occult blood testing, and gross necropsies were performed. Results showed that mechanical and thermal hypersensitivity persisted in the placebo group throughout the study (D0 to D2). CarpTab and Carp25SC groups effectively attenuated mechanical hypersensitivity compared with the baseline (D0 to D2). Compared with baseline, CarpGel-low attenuated mechanical hypersensitivity on D1 and CarpGel-high attenuated mechanical hypersensitivity on D2. All carprofen treatment groups, except CarpGel-high at D0, attenuated mechanical hypersensitivity compared with placebo. Thermal hypersensitivity persisted in all carprofen treatment groups compared with baseline values. However, compared with placebo, CarpTab, Carp25SC, and CarpGel-low provided attenuation of thermal hypersensitivity. Plasma carprofen concentrations did not significantly differ among oral formulations. Fecal occult blood testing was positive only in 1 of 6 mice in the CarpGel-high group at 1 and 2 d after administration. These findings support the use of orally administered CarpTab as an alternative analgesic to Carp25SC for incisional pain in NSG mice.
POLÍTICAS PÚBLICAS E VIOLÊNCIA OBSTÉTRICA:
Authors: Gevehr Daniel Luciano , Tomasini Ana Cristina
Published: February 2025

A violência contra a mulher possui distintas formas de expressão, sendo uma delas a violência obstétrica. O sistema jurídico brasileiro não possui uma lei federal específica sobre a violência obstétrica, apenas legislações genéricas sobre a temática. Esta forma de violência acarreta sofrimento na população do gênero feminino pelo mundo todo, desencadeando, inclusive, a mortalidade materna. O objetivo central foi analisar a percepção da experiência de parto de duzentas e quatorze mulheres. O problema de pesquisa pretende responder se a violência obstétrica é recorrente e banalizada durante o trabalho de parto. Para isso, utilizou-se a pesquisa documental e de campo com aplicação de questionário virtual às mulheres que vivenciaram a experiência de gerar vida. Verificou-se que 39% das pesquisadas foram vítimas de atos agressivos durante a assistência de parto; 7,5% confirmam ter vivenciado situações de constrangimento, recebendo apelidos, deboches ou xingamentos dentro da instituição hospitalar; e 14,5% das mulheres não foram ouvidas em suas queixas e dúvidas, percebendo a naturalização da dor por parte da equipe médica. Ouvindo às evidências, conclui-se que os atos de violência obstétrica foram recorrentes nas assistências de parto e que existe uma banalização desta forma de violência pela equipe de cuidado e atendimento à gestante/parturiente.
POR UMA EPISTEMOLOGIA CONSTITUCIONAL FEMINISTA:
Authors: Maliska Marcos , Santana Pereira Ticiane Louise
Published: February 2025

O constitucionalismo moderno ocidental, em sua origem marcadamente liberal e androcêntrico, forjou um ambiente propício para uma produção jurídica largamente influenciada pelas doxas do senso comum, que talharam uma ideia normalizante das desigualdades arbitrárias entre homens e mulheres. Em meados do século XX, no entanto, novas perspectivas inclusivas e redimensionadoras do sentido de igualdade substancial, impactaram os estudos de gênero, colocando a necessidade de uma revisão epistemológica do fenômeno jurídico, em prestígio à equidade e ao pluralismo. Desta forma, questiona-se, como foram moldadas estas desigualdades percebidas, se detectadas em um contexto histórico de prestígio às liberdades individuais? Quão estruturantes se apresentam estes discrímens arbitrários e em que fundamentos se apoiam essas narrativas justificantes? A ausência de uma percepção do fenômeno sociopolítico do gênero foi decisiva para se tecer uma realidade jurídica carente de abordagem isonômica e, efetivamente, democrática para homens e mulheres? Sob este viés, tem-se como base o uso do método de pesquisa de revisão bibliográfica de modo a priorizar o ponto focal da discussão: é possível, no atual cenário constitucional, o desenvolvimento de uma epistemologia feminista, garantidora da isonomia substancial de homens e mulheres, por meio da análise do fenômeno jurídico sob a perspectiva de gênero?
Problems and solutions of composite machining by electro-diamond methods for materials based on zirconium diboride
Authors: Yanyushkin Andrey , Lobanov Dmitriy , Yanyushkin Aleksandr , Skripnyak Vladimir , Skripnyak Vladimir
Published: February 2025

Problematic issues related to the development, machinability and application of new high-strength ceramic materials are viewed. Such materials possess high hardness comparable to the hardness of abrasive materials. Therefore, it makes difficult to produce such materials using traditional techniques. To solve this problem, we have proposed the modernization of the PP 600F machine with the implementation of combined electro-diamond processing of high-strength ceramic materials with diamond wheels on a binder metal. The modernization provides for the development of special components and structures of a current collector, a cathode for straightening a circle, a circuit for a technological current source and constructive solutions for automatic control of the straightening current. Based on the results of the study, rational cutting modes have been established to guarantee the quality of products made of high-strength composite materials. The experiments were performed with standard techniques using optical and electron microscopy. The tasks were solved taking into account the study of diamond wheels flow density on a metallic binder, as well as forces, power, cutting temperature, defects on the surface of the grinding wheel and the machined product. The solution for controlling the cutting capacity of a grinding wheel and the conditions of their operation in the self-sharpening mode is shown. Based on the stabilization of cutting power, the self-sharpening mode of diamond wheels on a metallic binder and grinding modes are switched on:Vgwh = 35 m/s; Spr = 0.5.1.5 m/min; Spr = 0,5…1,5 m/min; Spop = 0,02…0,05 mm/dv.stroke ipr = 0,2…0,6 A/cm2; itr = 4…6A/cm2. Using the example of grinding zirconium diboride with an A C 6 diamond wheel with a grain size of 125/100 in these modes, it guarantees the absence of micro, macro cracks, and the roughness of the machined surface within 0.2…0.4 microns.
The acrosome integration as a key prognostic factor of fertility (review)
Authors: Berelet T. , Korochkina E.
Published: February 2025

Purpose: study of data from domestic and foreign authors on the morphofunctional features of the acrosome, methods for assessing the acrosomal reaction and comparison of fertility data. Fertility is the ability of a sexually mature organism to produce viable offspring.

Fertility can be determined by various criteria, but one of the key factors is the assessment of the integrity of the acrosome. The acrosome is a part of the sperm, located at the top of its head. There are two main functions of the acrosome: the isolation of proteolytic and hydrolytic enzymes for the sperm to pass through the transparent shell of the egg, and ensuring the fusion of the sperm with the membrane of the female germ cell. Golgi apparatus, cytoskeleton, Sertoli cells and various proteins are involved in the formation of the acrosome. The acrosomal reaction is the exocytosis of the contents of the acrosome, as a result of which the sperm penetrates through the egg shells. The integrity of the acrosome can be assessed by several methods: electron microscopy with differentiated staining of the acrosome using different techniques, functional tests, fluorescence microscopy, radioimmunoanalysis.
Metabolic indicators in hens of different ages and at different reproductive states
Authors: Lebedeva I. Yu. , Mityashova O. , Montvila E.
Published: February 2025

The decline in the reproductive potential of hens by the end of the first productive period is closely related to the biological process of ovarian aging. At the same time, the functioning of the reproductive system is de termined by the intensity and direction of metabolic processes in the body of females.

Objective: The aim of the presented work was to study the relationship between biochemical markers of metabolic status and the manifestation of age-related decline in egg production in domestic hens.

Materials and methods. We performed a comparative study of blood biochemical indicators in young laying hens with long egg clutches (YLC, n=17) and in middle-aged hens at different reproductive states: with long egg clutches (MLC, n=10), with anovulatory long clutches (MALC, n=9), with short clutches (MSC, n=15) and with short clutches after molting (MSC-M, n=9). Biochemical blood parameters were determined simultaneously in all samples using an automatic biochemical analyzer.

Results. The concentration of total protein in the blood plasma of young birds was 1.2 times lower (p<0.01 0.05) than that of older birds in the three groups (MLC, MSC and MSC-M). The blood content of lipid metabolism components in hens of different ages and reproductive status did not differ. In young birds, the activity of alanine aminotransferase in the blood was 1.5 times higher (p<0.05) than in hens after molting (MSC-M), and the de Ritis coefficient was 1.4 times lower (p<0.05) than in hens of the MLC group. At the same time, in aged individuals in the MLC and MSC-M groups, the levels of phosphorus and iron were 1.4 times higher (p<0.01-0.05) compared to those in individuals in the YLC (phosphorus) and MSC (iron) groups.

Conclusions. The findings indicate that in laying hens, the content of total protein in the blood increased with age, which did not depend on the presence of signs of reproductive aging. Furthermore, they point to com pensatory changes in mineral metabolism indicators and the aminotransferase activity in aged hens that main tain a high intensity of egg laying, as well as in birds that have resumed egg laying after molting.
i. can. teach.
Authors: Jeong Dong Hyeon
Published: February 2025

"Who am i/I? And what is with the capitalization of i/I? Jione Havea did say that this is driven by Western/colonial ego that centers upon the self above un-capitalized others. To start this writing journey with self-aggrandizement buttressed by MS Word’s “red squiggly lines” fumigates my anathemized quest for organic relationality with the other..."
Can We Breathe? : Exploring a Pedagogy of Breath for Theological Education
Authors: Williams Khalia
Published: February 2025

"It was the fifth week of the fall semester, and I was teaching my Womanist/Feminist Spirituality and Worship course. A student walked into our Wednesday afternoon class a few minutes early, plopped down into her chair, and let out a deep sigh – “Hhhaaa!” She then said, “Now I can feel human” to the classmate seated beside her..."
War and Water: An Ecowomanist Perspective on Expanding Casualties of War in Gaza
Authors: Laughinghouse Candace
Published: February 2025

"A time comes when silence is betrayal. War is the enemy of the poor.
Social change comes most meaningfully through nonviolent action.
...the greatest purveyor of violence in the world today – my own government..."
Beyond Monoculture: Humanities and the Root of Land Grant Universities
Authors: Dees Sarah
Published: February 2025

"As I write, I’m sitting at the edge of a reconstructed prairie near Ames, Iowa, sipping a tart local beer and soaking in the view. Native grasses and wildflowers sway in the breeze. A variety of birds flit about, carrying on whatever important bird business the day requires. When the sun dips down, the sound of frogs and cicadas intensifies..."
Prevalence and Risk Factors for Neck and Upper Limb Musculoskeletal Disabilities Among Postpartum Women
Authors: Algabbani Maha F. , Alazmi Abeer A. , Alqabbani Samiah , Almurdi Muneera M. , Abdelkader Samiha M. I. , Alruwaili Maram , Alhammad Saad A. , AlHumaid Lolwah AlRashed , Alrushud Asma , Almuwais Afrah , Shaheen Afaf A. M.
Published: February 2025

Background: Postpartum women often experience musculoskeletal pain due to physiological and biomechanical changes during pregnancy and childbirth, which can result in disability. This study assessed the prevalence of neck and upper limb pain and disability in postpartum women, as well as the factors associated with these conditions. Methods: A descriptive cross-sectional study was conducted to collect data from postpartum women through an online self-administered questionnaire. The questionnaire included items on the demographic variables, the Nordic Musculoskeletal Symptoms Questionnaire, the Neck Disability Index, the Disabilities of the Arm, Shoulder, and Hand scale, as well as the Pain Intensity Numeric Rating Scale. Results: Among a sample of 400 postpartum women aged 20–50 years, 82.5% reported experiencing pain in at least one part of their upper body. Neck pain was the most prevalent (65.5%), followed by pain in the shoulders (63.3%), arms (58.3%), and hands (57.0%). Cesarean section delivery and moderate-to-severe pain intensity were identified as significant risk factors for developing mild disability among women who reporting neck pain. Upper limb pain and being aged 41–50 years were significant risk factors for mild disabilities among postpartum women. Conclusions: Disability was prevalent among the sample of postpartum women, highlighting the importance of healthcare providers in addressing this issue.
The Role of Serum Low-Density Lipoprotein and Gamma-Glutamyl Transferase Levels in Missed Miscarriage among Women over 35: A Case-Cohort Study
Authors: Zhou Ni , Hou Yue-min , Ma Miao-yan , Qi Yan-hua , Lu Xiao-ning , Wu Jin-fang
Published: February 2025

Background: Current research on the characteristics of missed miscarriage (MM) in women over the age of 35 is limited. This study investigates the role of serum metabolites for MM among women in this age group. Methods: This study included a total of 80 women over the age of 35 who experienced MM and 66 women over the age of 35 with healthy pregnancies, conducted between March 2021 and June 2022. General information, including age, gestational age, body mass index (BMI), gravidity, live birth, history of spontaneous miscarriage, drug or radiation exposure, occupation, and pregnancy-related complications, was collected. The recorded serum indicators included total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), lactate dehydrogenase (LDH), and gamma-glutamyl transferase (GGT). Potential risk factors for MM in the case-cohort were identified using univariate and multivariate logistic regression analyses. The diagnostic relevance of serum markers for MM was examined through receiver operating characteristics (ROC) curve analysis. Results: The incidence of MM increased with higher LDL and GGT values (p < 0.05). The area under the curve (AUC) was 0.709 for LDL and 0.792 for GGT. An LDL value >2.31 identified MM with a sensitivity of 72.5% and a specificity of 66.7%, while a GGT value >15.5 identified MM with a sensitivity of 78.8% and a specificity of 72.7%. However, the combined diagnostic accuracy of the two indicators was superior of that of either single index (AUC = 0.880, sensitivity = 92.5%, specificity = 72.7%; Z = 4.238, 2.813, p < 0.001, p < 0.01). Conclusions: In women over the age of 35, serum LDL and GGT are high-risk factors for MM, each potentially playing a significant role in its diagnosis. The combination of these two markers may improve diagnostic accuracy. The preliminary results of this study warrant further investigation through a well-designed, multicenter prospective study.
Exploring Molecular Pathways in Refractive Errors Associated with Inherited Retinal Dystrophies
Authors: D’Esposito Fabiana , Gagliano Caterina , Avitabile Alessandro , Gagliano Giuseppe , Musa Mutali , Capobianco Matteo , Visalli Federico , Dammino Edoardo , Zeppieri Marco , Cordeiro Maria Francesca
Published: February 2025

The term inherited retinal dystrophies (IRDs) refers to a diverse range of conditions characterized by retinal dysfunction, and mostly deterioration, leading to a gradual decay of the visual function and eventually to total vision loss. IRDs have a global impact on about 1 in every 3000 to 4000 individuals. However, the prevalence statistics might differ significantly depending on the exact type of dystrophy and the demographic being examined. The cellular pathophysiology and genetic foundation of IRDs have been extensively studied, however, knowledge regarding associated refractive errors remain limited. This review aims to clarify the cellular and molecular processes that underlie refractive errors in IRDs. We did a thorough search of the current literature (Pubmed, accession Feb 2024), selecting works describing phenotypic differences among genes-related to IRDs, particularly in relation to refractive errors. First, we summarize the wide range of IRDs and their genetic causes, describing the genes and biological pathways connected to the etiology of the disease. We then explore the complex relationship between refractive errors and retinal dysfunction, including how the impairment of the vision-related mechanisms in the retina can affect ocular biometry and optical characteristics. New data about the involvement of aberrant signaling pathways, photoreceptor degeneration, and dysfunctional retinal pigment epithelium (RPE) in the development of refractive errors in IRDs have been examined. We also discuss the therapeutic implications of refractive defects in individuals with IRD, including possible approaches to treating visual impairments. In addition, we address the value of using cutting-edge imaging methods and animal models to examine refractive errors linked to IRDs and suggest future lines of inquiry for identifying new targets for treatment. In summary, this study presents an integrated understanding of the cellular and molecular mechanisms underlying refractive errors in IRDs. It illuminates the intricacies of ocular phenotypes in these conditions and offers a tool for understanding mechanisms underlying isolated refractive errors, besides the IRD-related forms.
Advances in the Treatment of Epilepsy by Electrostimulation of the Pulvinar
Authors: Shan Bingyang , Dai Yang , Liu Quanlei , Hou Changkai , Wang Yihe , Wei Penghu , Zhao Guoguang
Published: February 2025

Neuroregulatory therapy, encompassing deep brain stimulation and responsive neurostimulation, is increasingly gaining attention for the treatment of drug-resistant temporal and occipital lobe epilepsy. Beyond the approved anterior nucleus of the thalamus, the pulvinar nucleus of the thalamus is a potential stimulation target. Through a confluence of animal studies, electrophysiological research, and imaging studies, the pulvinar has been identified as having extensive connections with the visual cortex, prefrontal cortex, limbic regions, and multimodal sensory associative areas, playing a pivotal role in multisensory integration and serving as a propagation node in both generalized and focal epilepsy. This review synthesizes recent research on the pulvinar in relation to cortical and epileptic networks, as well as the efficacy of neuroregulatory therapy targeting the pulvinar in the treatment of temporal and occipital lobe epilepsy. Further research is warranted to elucidate the differential therapeutic effects of stimulating various subregions of the pulvinar and the specific mechanisms underlying the treatment of epilepsy through pulvinar stimulation.
Recent Clinical Updates of Hypertrophic Cardiomyopathy and Future Therapeutic Strategies
Authors: Zhao Mengya , He Xianzhen , Min Xinwen , Yang Handong , Wu Wenwen , Zhong Jixin , Xu Hao , Chen Jun
Published: February 2025

Hypertrophic cardiomyopathy (HCM) is the most prevalent inherited cardiomyopathy transmitted in an autosomal dominant manner to offspring. It is characterized by unexplained asymmetrical hypertrophy primarily affecting the left ventricle and interventricular septum while potentially causing obstruction within the left ventricular outflow tract (LVOT). The clinical manifestations of HCM are diverse, ranging from asymptomatic to severe heart failure (HF) and sudden cardiac death. Most patients present with obvious symptoms of left ventricular outflow tract obstruction (LVOTO). The diagnosis of HCM mainly depends on echocardiography and other imaging examinations. In recent years, myosin inhibitors have undergone clinical trials and gene therapy, which is expected to become a new treatment for HCM, has been studied. This article summarizes recent clinical updates on the epidemiology, pathogenesis, diagnostic methods, treatment principles, and complication prevention and treatment of HCM, to provide new ideas for follow-up research.
Control of Pulse Pressure and Factors Affecting it among the Geriatric Population Suffering from Hypertension within the Community
Authors: Yang Qianfeng , Xu Lishuang , Gao Qingxia , Gao Zhiguang
Published: February 2025

Background: To explore the impact of employing the Knowledge, Attitude, and Practice (KAP) model within a unified community physician intervention aimed at managing pulse pressure among elderly individuals with hypertension in Shenyang, along with its associated influencing variables. Methods: 2660 hypertensive patients were recruited in the community of Shenyang City in January 2020. After a 1-year KAP intervention by a unified community physician, KAP changes and pulse pressure levels were compared before and after the intervention. Meanwhile, the relevant influences affecting pulse pressure control were explored. Descriptive analysis and multifactorial logistic regression were used. Results: A significant decrease in pulse pressure by 10.71 mmHg (95% CI: 10.09, 11.33 mmHg) was noted among elderly individuals with hypertension in the community after undergoing a rigorous one-year intervention program (t = 33.79, p < 0.05). Pulse pressure control increased from 32.59% at baseline to 64.92% (χ2 = 556.43, p < 0.01). Compared to pre-intervention, knowledge about hypertension, awareness of prevention, medication and behavioural adherence improved significantly. A multifactorial logistic regression analysis revealed that the risk factors for pulse pressure control were female sex, a history of comorbid diabetes mellitus and poor adherence to medication due to forgetfulness. Conclusions: Unified community physician interventions can change the perceptions of elderly hypertensive patients, improve medication adherence, and improve poor lifestyle habits, thereby improving pulse pressure control in the geriatric population with hypertension residing in local communities.