bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictive Value of the Velocity of Collateral Filling in Patients with Acute Ischemic Stroke
Authors: Beyer Sebastian E , von Baumgarten Louisa , Thierfelder Kolja M , Rottenkolber Marietta , Janssen Hendrik , Dichgans Martin , Johnson Thorsten RC , Straube Andreas , Ertl-Wagner Birgit , Reiser Maximilian F , Sommer Wieland H
Published: November 2014

The velocity of collateral filling can be assessed in dynamic time-resolved computed tomography (CT) angiographies and may predict initial CT perfusion (CTP) and follow-up lesion size. We included all patients with an M1± internal carotid artery (ICA) occlusion and follow-up imaging from an existing cohort of 1791 consecutive patients who underwent multimodal CT for suspected stroke. The velocity of collateral filling was quantified using the delay of time-to-peak (TTP) enhancement of the M2 segment distal to the occlusion. Cerebral blood volume (CBV) and mean transit time (MTT)-CBV mismatch were assessed in initial CTP. Follow-up lesion size was assessed by magnetic resonance imaging (MRI) or non-enhanced CT (NECT). Multivariate analyses were performed to adjust for extent of collateralization and type of treatment. Our study comprised 116 patients. Multivariate analysis showed a short collateral blood flow delay to be an independent predictor of a small CBV lesion ( P<0.001) and a large relative mismatch ( P<0.001) on initial CTP, of a small follow-up lesion ( P<0.001), and of a small difference between initial CBV and follow-up lesion size ( P=0.024). Other independent predictors of a small lesion on follow-up were a high morphologic collateral grade ( P=0.001), lack of an additional ICA occlusion ( P=0.009), and intravenous thrombolysis ( P=0.022). Fast filling of collaterals predicts initial CTP and follow-up lesion size and is independent of extent of collateralization.
Enteral Supplements of a Carbon Monoxide Donor CORM-A1 Protect against Cerebrovascular Dysfunction Caused by Neonatal Seizures
Authors: Liu Jianxiong , Fedinec Alexander L , Leffler Charles W , Parfenova Helena
Published: November 2014

Cerebral blood flow dysregulation caused by oxidative stress contributes to adverse neurologic outcome of seizures. A carbon monoxide (CO) donor CORM-A1 has antioxidant and cytoprotective properties. We investigated whether enteral supplements of CORM-A1 can improve cerebrovascular outcome of bicuculline-induced seizures in newborn piglets. CORM-A1 (2 mg/kg) was given to piglets via an oral gastric tube 10 minutes before or 20 minutes after seizure onset. Enteral CORM-A1 elevated CO in periarachnoid cerebrospinal fluid and produced a dilation of pial arterioles. Postictal cerebral vascular responses to endothelium-, astrocyte-, and vascular smooth muscle-dependent vasodilators were tested 48 hours after seizures by intravital microscopy. The postictal responses of pial arterioles to bradykinin, glutamate, the AMPA receptor agonist quisqualic acid, ADP, and heme were greatly reduced, suggesting that seizures cause injury to endothelial and astrocyte components of the neurovascular unit. In contrast, in the two groups of piglets receiving enteral CORM-A1, the postictal cerebral vascular responsiveness to these dilators was improved. Overall, enteral supplements of CORM-A1 before or during seizures offer a novel effective therapeutic option to deliver cytoprotective mediator CO to the brain, reduce injury to endothelial and astrocyte components of cerebral blood flow regulation and to improve the cerebrovascular outcome of neonatal seizures.
Cotton cytochrome P450 CYP82D regulates systemic cell death by modulating the octadecanoid pathway
Authors: Sun Longqing , Zhu Longfu , Xu Li , Yuan Daojun , Min Ling , Zhang Xianlong
Published: November 2014

Plant oxylipins are derived from unsaturated fatty acids and play roles in plant growth and development as well as defence. Although recent studies have revealed that fatty acid metabolism is involved in systemic acquired resistance, the precise function of oxylipins in plant defence remains unknown. Here we report a cotton P450 gene SILENCE-INDUCED STEM NECROSIS (SSN), RNAi suppression of which causes a lesion mimic phenotype. SSN is also involved in jasmonate metabolism and the response to wounding. Fatty acid and oxylipin metabolite analysis showed that SSN overexpression causes hyperaccumulation of hydroxide and ketodiene fatty acids and reduced levels of 18:2 fatty acids, whereas silencing causes an imbalance in LOX (lipoxygenase) expression and excessive hydroperoxide fatty acid accumulation. We also show that an unknown oxylipin-derived factor is a putative mobile signal required for systemic cell death and hypothesize that SSN acts as a valve to regulate HR on pathogen infection.
Patients’ experience of identifying and managing exacerbations in COPD: a qualitative study
Authors: Williams Veronika , Hardinge Maxine , Ryan Sara , Farmer Andrew
Published: November 2014

Background:

Effective self-management in chronic obstructive pulmonary disease (COPD) is crucial to reduce hospital admissions and improve outcomes for patients. This includes early detection and treatment of exacerbations by patients themselves.

Aims:

To explore patients’ current understanding and experience of managing and identifying COPD exacerbations at home.

Methods:

A qualitative, interview-based study was carried out in patients’ homes. Interviews were audio-recorded, transcribed and analysed using a grounded theory approach. Forty-four patients (17 women, 27 men; age range 55–85 years), with moderate-to-very-severe COPD, were recruited to the interview study from primary and secondary care settings in Oxford, UK, during 2012–2013.

Results:

Patients identified exacerbations on the basis of measurable, ‘visible’ symptoms, such as cough and sputum and ‘invisible’ symptoms, such as chest sensations and bodily knowledge. Most patients seemed to use a combination of these approaches when identifying exacerbations, according to the symptoms that had the most impact on their well-being. Patients used additional self-management strategies during an exacerbation, such as self-medication (antibiotics and steroids) and monitored their recovery. Contact with health-care professionals usually occurred when patients felt no longer able to manage themselves.

Conclusions:

Patients use both assessment of objective biomarkers, which are aligned with medical knowledge, and subjective symptoms based on their experience, to identify and manage exacerbations of COPD. Health-care professionals and clinicians should acknowledge this ‘expert patient’ knowledge and integrate this into patients’ care plans to facilitate early recognition and treatment of exacerbations.
Quantum magnetic phase transition in square-octagon lattice
Authors: Bao An , Tao Hong-Shuai , Liu Hai-Di , Zhang XiaoZhong , Liu Wu-Ming
Published: November 2014

Quantum magnetic phase transition in square-octagon lattice was investigated by cellular dynamical mean field theory combining with continuous time quantum Monte Carlo algorithm. Based on the systematic calculation on the density of states, the double occupancy and the Fermi surface evolution of square-octagon lattice, we presented the phase diagrams of this splendid many particle system. The competition between the temperature and the on-site repulsive interaction in the isotropic square-octagon lattice has shown that both antiferromagnetic and paramagnetic order can be found not only in the metal phase, but also in the insulating phase. Antiferromagnetic metal phase disappeared in the phase diagram that consists of the anisotropic parameter λ and the on-site repulsive interaction U while the other phases still can be detected at T = 0.17. The results found in this work may contribute to understand well the properties of some consuming systems that have square-octagon structure, quasi square-octagon structure, such as ZnO.
A new potentiometric sensor for the determination of ketamine hydrochloride in ampoules and urine
Authors: Abu Shawish Hazem M. , Saadeh Salman M. , Tamos Hassan , Abed-Almonem Khalid I. , Al khalili Osama
Published: November 2014

Ketamine drug in urine and pharmaceutical preparations was determined by a new chemically modified carbon paste electrode (CMCPE) based on an ion-exchanger of ketamine hydrochloride with sodium tetraphenylborate (KT-TPB) as a chemical modifier.
Insight into the efficient transfection activity of a designed low aggregated magnetic polyethyleneimine/DNA complex in serum-containing medium and the application in vivo
Authors: Xie Li , Jiang Qian , He Yiyan , Nie Yu , Yue Dong , Gu Zhongwei
Published: November 2014

In vitro fate of designed low aggregated magnetic polyethyleneimine/DNA (MPD-cc) complexes and in vivo study via systemic administration.
Tunable photoluminescence and direct white-light emission in Mg-based coordination networks
Authors: Wu Zhao-Feng , Tan Bin , Wang Jin-Yun , Du Cheng-Feng , Deng Zhong-Hua , Huang Xiao-Ying
Published: November 2014

The bpy, dpe and dppe were introduced, respectively, to construct Mg-NDC CPs exhibiting tunable photoluminescence and even direct white-light emission.
Stereochemistry of cage amine complexes – probing the ligand conformational flexibility with hydrogen bonds
Authors: Ling Irene , Sobolev Alexandre N. , Hashim Rauzah , Harrowfield Jack M.
Published: November 2014

Structure determinations for some Co(iii) sarcophagine complexes show that there is no evidence that the H-bonding involving the NH centres of the complex cations is influenced by electronic effects due to the substituents.
Performance improvement of Li-rich layer-structured Li1.2Mn0.54Ni0.13Co0.13O2 by integration with spinel LiNi0.5Mn1.5O4
Authors: Feng Xin , Yang Zhenzhong , Tang Daichun , Kong Qingyu , Gu Lin , Wang Zhaoxiang , Chen Liquan
Published: November 2014

Spinel LiNi0.5Mn1.5O4 integration helps to suppress such degradation and that the integrated LiNi0.5Mn1.5O4 “absorbs” the cations that would otherwise form a LiMn2O4-like phase.
Visible-light sensitization of boron-doped nanocrystalline diamond through non-covalent surface modification
Authors: Krysova Hana , Vlckova-Zivcova Zuzana , Barton Jan , Petrak Vaclav , Nesladek Milos , Cigler Petr , Kavan Ladislav
Published: November 2014

The boron-doped diamond electrode is efficiently sensitized with a light-harvesting molecule using a facile and versatile synthetic method.
Kinetic dielectric decrement revisited: phenomenology of finite ion concentrations
Authors: Sega Marcello , Kantorovich Sofia , Arnold Axel
Published: November 2014

A phenomenological theory describes how water is dynamically depolarized by the motion of ions in finite concentration solutions.
Oxygen vacancy and hole conduction in amorphous TiO2
Authors: Pham Hieu H. , Wang Lin-Wang
Published: November 2014

The amorphous titanium dioxide (a-TiO2) has drawn attention recently due to the finding that it holds promise for coating conventional photoelectrodes for corrosion protection while still allowing the holes to transport to the surface.
Spectro-microscopic photoemission evidence of charge uncompensated areas in Pb(Zr,Ti)O3(001) layers
Authors: Popescu Dana Georgeta , Huşanu Marius Adrian , Trupinǎ Lucian , Hrib Luminiţa , Pintilie Lucian , Barinov Alexei , Lizzit Silvano , Lacovig Paolo , Teodorescu Cristian Mihail
Published: November 2014

Uncompensated ferroelectric layers with large voltage differences between faces: photoinduced electron–hole pairs build progressively charged sheets screening the depolarization field.
Developing an aqueous approach for synthesizing Au and M@Au (M = Pd, CuPt) hybrid nanostars with plasmonic properties
Authors: Du Jingshan , Yu Junjie , Xiong Yalin , Lin Zhuoqing , Zhang Hui , Yang Deren
Published: November 2014

A general route for controllably synthesizing Au-based nanostars was developed in an aqueous solution containing CTAB and ethanolamine.
Synthesis, structure, and magnetism of non-planar heptanuclear lanthanide(iii) complexes
Authors: Goura Joydeb , Walsh James P. S. , Tuna Floriana , Chandrasekhar Vadapalli
Published: November 2014

The reaction of 2-methoxy-6-(pyridine-2-yl-hydrazonomethyl) phenol (LH) with lanthanide(iii) salts (Gd, Tb, Dy, Ho and Er) in the presence of an excess of triethylamine afforded a series of non-planar heptanuclear homometallic complexes. The Gd(iii) analogue shows good MCE behaviour (−ΔSm(T) = 27.7 J kg−1 K−1 at 3 K over 0–7 T).
Improving the carrier balance of light-emitting electrochemical cells based on ionic transition metal complexes
Authors: Su Hai-Ching , Hsu Jia-Hong
Published: November 2014

Improved carrier balance of a light-emitting electrochemical cell reduces exciton quenching near the doped layers, rendering a higher device efficiency.
The role of solvents in framework dimensionality and their effect on band gap energy
Authors: Asha K. S. , Kavyasree P. R. , George Anu , Mandal Sukhendu
Published: November 2014

Solvents play a crucial role towards the dimensionality and band gap energy of hybrid framework materials.
Influence of the central metal ion in controlling the self-assembly and magnetic properties of 2D coordination polymers derived from [(NiL)2M]2+ nodes (M = Ni, Zn and Cd) (H2L = salen-type di-Schiff base) and dicyanamide spacers
Authors: Das Lakshmi Kanta , Gómez-García Carlos J. , Ghosh Ashutosh
Published: November 2014

Three new 2D coordination polymers of different networks with significant variation in magnetic properties have been synthesized by changing the central metal in the trinuclear nodes.
p-Type mesoscopic NiO as an active interfacial layer for carbon counter electrode based perovskite solar cells
Authors: Liu Zonghao , Zhang Meng , Xu Xiaobao , Bu Lingling , Zhang Wenjun , Li Wenhui , Zhao Zhixin , Wang Mingkui , Cheng Yi-Bing , He Hongshan
Published: November 2014

Replacement of the ZrO2insulator layer in the state-of-the-art TiO2/ZrO2/carbon structure by mesoscopic p-type NiO particles led to 39% increase of energy conversion efficiency of perovskite solar cells.
Ancillary ligand assisted self-assembly of coordination architectures of Mn(ii): the effect of the N-alkyl group on a tridentate ligand
Authors: Khullar Sadhika , Mandal Sanjay K.
Published: November 2014

For the first time it is shown that a subtle change in the N-alkyl group (methyl or ethyl) of a tridentate ancillary ligand, bis(2-pyridylmethyl)alkylamine, is responsible for the diversity of product formation under similar conditions. Through their water vapor adsorption study, a structure-property correlation is established.
Emission energy of azole-based ionic iridium(iii) complexes: a theoretical study
Authors: Pla Paula , Junquera-Hernández José M. , Bolink Henk J. , Ortí Enrique
Published: November 2014

Tuning the emission color of azole-based iridium(iii) complexes by changing the number and position of nitrogen atoms in the azole ring.
Structural diversity of five new bitriazole-based complexes: luminescence, sorption, and magnetic properties
Authors: Du Li-Yun , Wang Hui , Liu Ge , Xie Dong , Guo Fu-Sheng , Hou Lei , Wang Yao-Yu
Published: November 2014

Employing a new bitriazole ligand, five complexes were assembled that display diverse structures, selective CO2/CH4 adsorption, luminescent sensing, and antiferromagnetic properties.
Cleavage of an aryl carbon–nitrogen bond of a phosphazido iron(ii) complex promoted by hydride metathesis
Authors: Ogawa Takahiko , Suzuki Tatsuya , Hein Nicholas M. , Pick Fraser S. , Fryzuk Michael D.
Published: November 2014

The unexpected reaction of a Fe(ii) enamidophosphazide complex with KBEt3H, which results in the elimination of N2 and 1,3-Me2C6H4 to generate a dinuclear Fe(ii) derivative with bridging phosphinimido units, is presented along with mechanistic studies.
Stabilization of Si microwire arrays for solar-driven H2O oxidation to O2(g) in 1.0 M KOH(aq) using conformal coatings of amorphous TiO2
Authors: Shaner Matthew R. , Hu Shu , Sun Ke , Lewis Nathan S.
Published: November 2014

Stable water oxidation for >2200 h using Si microwires conformally coated with an amorphous TiO2 protective coating and NiCrOx electrocatalyst.
Environmental and economic assessment of lactic acid production from glycerol using cascade bio- and chemocatalysis
Authors: Morales Merten , Dapsens Pierre Y. , Giovinazzo Isabella , Witte Julia , Mondelli Cecilia , Papadokonstantakis Stavros , Hungerbühler Konrad , Pérez-Ramírez Javier
Published: November 2014

The viability of a novel bio-/chemocatalytic process for lactic acid production from crude glycerol is demonstrated in terms of sustainability and economics.
Bioelectrochemical systems for nitrogen removal and recovery from wastewater
Authors: Rodríguez Arredondo M. , Kuntke P. , Jeremiasse A. W. , Sleutels T. H. J. A. , Buisman C. J. N. , ter Heijne A.
Published: November 2014

Removal of nitrogen compounds from wastewater is essential to prevent pollution of receiving water bodies. Bioelectrochemical systems enable energy-efficient nitrogen removal and even recovery of ammonia from wastewaters.
Recent advances in catalysis in micellar media
Authors: La Sorella Giorgio , Strukul Giorgio , Scarso Alessandro
Published: November 2014

Micellar catalysis is nowadays a well established approach to convert traditional catalytic reactions commonly run in organic solvents into more efficient, selective, recyclable green catalytic reactions.
Riboregulation of the bacterial actin-homolog MreB by DsrA small noncoding RNA
Authors: Cayrol Bastien , Fortas Emilie , Martret Claire , Cech Grzegorz , Kloska Anna , Caulet Stephane , Barbet Marion , Trépout Sylvain , Marco Sergio , Taghbalout Aziz , Busi Florent , Wegrzyn Grzegorz , Arluison Véronique
Published: November 2014

This study shows riboregulation by DsrA sRNA that binds the mreB 5′-region to alter MreB levels and cell morphology during stresses.
Selection of aptamers specific for glycated hemoglobin and total hemoglobin using on-chip SELEX
Authors: Lin Hsin-I , Wu Ching-Chu , Yang Ching-Hsuan , Chang Ko-Wei , Lee Gwo-Bin , Shiesh Shu-Chu
Published: November 2014

Selection of blood glycated hemoglobin (HbA1c)- and total hemoglobin (Hb)-specific single-stranded DNA aptamers was performed on a microfluidic chip to continuously and automatically carry out multiple rounds of systematic evolution of ligands by exponential enrichment (SELEX) processes.
Targeting FR-expressing cells in ovarian cancer with Fab-functionalized nanoparticles: a full study to provide the proof of principle from in vitro to in vivo
Authors: Quarta Alessandra , Bernareggi Davide , Benigni Fabio , Luison Elena , Nano Giuseppe , Nitti Simone , Cesta Maria Candida , Di Ciccio Luciano , Canevari Silvana , Pellegrino Teresa , Figini Mariangela
Published: November 2014

Specific targeting of Fab-functionalized nanoparticles has been achieved both in vitro and in vivo.
Real-time monitoring for the morphological variations of single gold nanorods
Authors: Xie Tao , Jing Chao , Ma Wei , Ding Zhifeng , Gross Andrew James , Long Yi-Tao
Published: November 2014

The morphological characteristics of metal nanoparticles, particularly the shape, play an essential role in the optical, physical and chemical properties.
A photo-stable and electrochemically stable poly(dumbbell-shaped molecules) for blue electrophosphorescent host materials
Authors: Li Lu , Hu Tian-Qing , Yin Cheng-Rong , Xie Ling-Hai , Yang Yang , Wang Chao , Lin Jin-Yi , Yi Ming-Dong , Ye Shang-Hui , Huang Wei
Published: November 2014

Hindrance functionalization at the reactive sites makes π-stacked polymers highly stable with the potential applications related to organic electronic devices.
A room-temperature synthesis of 2,2′-bisoxazoles through palladium-catalyzed oxidative coupling of α-isocyanoacetamides
Authors: Wang Jian , Luo Shuang , Li Jing , Zhu Qiang
Published: November 2014

A novel one-step synthesis of both symmetric and unsymmetric 2,2′-bisoxazoles starting from simple acyclic α-isocyanoacetamides was achieved.
FTIR study and bioadsorption kinetics of bioadsorbent for the analysis of metal pollutants
Authors: Rahman Nik Norulaini Nik Abd. , Shahadat Mohammad , Won Chew Ann , Omar Fatehah Mohd
Published: November 2014

Elevated concentrations of heavy metals in groundwater cause many environmental problems. This paper reports adsorption behavior of a green bioadsorbent (Trichoderma sp.) for the removal of heavy metal ions from industrial effluents.
Augmentation of properties on sparingly loaded nanocomposites via functionalized single-walled carbon nanotubes using a covalent approach
Authors: Murali Adhigan , Gurusamy-Thangavelu Senthil A. , Jaisankar Sellamuthu N. , Mandal Asit Baran
Published: November 2014

Polymer nanocomposites are developed, for the first time, as transparent film by covalent addition of [OH]n–SWCNTs with PU via an efficient route. PU nanocomposites, which were augmented, show enhanced mechanical, thermal and conductivity properties.
Zinc, copper and nickel derivatives of 2-[2-bromoethyliminomethyl]phenol as topoisomerase inhibitors exhibiting anti-proliferative and anti-metastatic properties
Authors: Lee Sze Koon , Tan Kong Wai , Ng Seik Weng
Published: November 2014

Transition metal (Zn, Cu and Ni) derivatives of (2-[2-bromoethyliminomethyl]phenol), were found to inhibit topoisomerase I activity, induce DNA cleavage and bind to calf thymus DNA. The compounds are also cytotoxic and anti-invasive against PC3.
A magnetically recyclable Fe3O4@SiO2/Mn(iii) chiral salen complex as a highly selective and versatile heterogeneous nanocatalyst for the oxidation of olefins and sulfides
Authors: Allahresani Ali , Nasseri Mohammad Ali
Published: November 2014

An efficient system for the selective oxidation of alkenes using TBHP and sulfides using aqueous 30% H2O2 catalyzed by a new magnetically recoverable Mn(iii) salen complex with high selectivity and excellent yields was developed.
Facile synthesis of graphene-clamped nanostructured SnO2 materials for lithium-ion batteries
Authors: Hong Yanzhong , Zhang Jianyin , Wang Zhiyong , Stankovich Joseph J. , Jin Xianbo
Published: November 2014

Facile preparation of high-performance graphene/SnO2 nano-composites for Li-ion batteries based on expansion and exfoliation of SIGO is demonstrated.
A styryl-containing aza-BODIPY as a near-infrared dye
Authors: Jiang Xin-Dong , Xi Dongmei , Zhao Jiuli , Yu Haifeng , Sun Guo-Tao , Xiao Lin-Jiu
Published: November 2014

A novel styryl-containing pyrrole was developed by the reaction of E-4-phenylbut-3-en-2-one with 3-phenyl-2H-azirine in the presence of LDA. Utilizing this pyrrole, asymmetric styryl-containing aza-BODIPYs have been prepared in the NIR region as a result of the extension of conjugation.
A study of buried channel formation in oxidized porous silicon
Authors: Dang Z. Y. , Liu D. Q. , Azimi S. , Breese M. B. H.
Published: November 2014

We have studied the formation of buried, hollow channels in oxidized porous silicon produced by a process based on focused high-energy ion irradiation of low resistivity, p-type silicon.
Reduction of ferrylmyoglobin by cysteine as affected by pH
Authors: Libardi S. H. , Pindstrup H. , Amigo J. M. , Cardoso D. R. , Skibsted L. H.
Published: November 2014

Herein we report the kinetics and mechanism by which hypervalent heme-iron species formed in the gut may be deactivated by thiols like cysteine and glutathione.
Synthesis and characterization of fully biobased aromatic polyols – oxybutylation of condensed tannins towards new macromolecular architectures
Authors: Arbenz Alice , Avérous Luc
Published: November 2014

New fully biobased macropolyols obtained by oxybutylation of different tannins.
Ultrasonic assisted dimeric cinchona based chiral phase transfer catalysts for highly enanatioselective synthesis of epoxidation of α,β-unsaturated ketones
Authors: Sivamani Jayaraman , Ashokkumar Veeramanoharan , Sadhasivam Velu , Duraimurugan Kumaraguru , Siva Ayyanar
Published: November 2014

New types of bis-quaternary ammonium bromide as chiral multisite phase transfer catalysts derived from cinchona alkaloids have been developed and evaluated for the enantioselective epoxidation of chalcones in the presence of lower concentrations of various oxidants, bases and ultrasonic irradiation conditions.
Transition from rings to spots in a precipitation reaction–diffusion system
Authors: Dayeh Malak , Ammar Manal , Al-Ghoul Mazen
Published: November 2014

We report for the first time the transition from rings to spots with squared/hexagonal symmetry in a periodic precipitation system, which consists of sulfide/hydroxide ions diffusing into a gel matrix containing dissolved cadmium(ii) ions.
Design and synthesis of novel carbazolo–thiazoles as potential anti-mycobacterial agents using a molecular hybridization approach
Authors: Shaikh Mahamadhanif S. , Palkar Mahesh B. , Patel Harun M. , Rane Rajesh A. , Alwan Wesam S. , Shaikh Mahidansha M. , Shaikh Iqbal M. , Hampannavar Girish A. , Karpoormath Rajshekhar
Published: November 2014

A series of novel carbazolo–thiazoles was synthesized and evaluated for in vitro anti-mycobacterial activity.
A continuous flow microfluidic-MS system for efficient OBOC screening
Authors: Wang Weizhi , Wei Zewen , Wang Zihua , Ma Huailei , Bu Xiangli , Hu Zhiyuan
Published: November 2014

A microfluidic chip based method utilized for effective screening of high-throughput peptide libraries was achieved. 105beads was processed within 4 hours and peptide ligands towardtarget protein AHA and APN were successfully discovered.
Silver incorporated antibacterial, cell compatible and bioactive titania layer on Ti metal for biomedical applications
Authors: Rajendran Archana , Pattanayak Deepak K.
Published: November 2014

Surface modification of titanium metal incorporated with silver to improve the antibacterial activity, cell compatibility and biological affinity of orthopaedic and dental devices.
A peptide from human semenogelin I self-assembles into a pH-responsive hydrogel
Authors: Frohm B. , DeNizio J. E. , Lee D. S. M. , Gentile L. , Olsson U. , Malm J. , Åkerfeldt K. S. , Linse S.
Published: November 2014

The 11-residue peptide GSFSIQYTYHV from human semenogelin I forms a hydrogel with optimal stability at pH 7–9.
Polydispersity and gelation in concentrated colloids with competing interactions
Authors: Zhang Tian Hui , Kuipers Bonny W. M. , Tian Wen-de , Groenewold Jan , Kegel Willem K.
Published: November 2014

In colloids with competing interactions, an electric field-induced column-like structure relaxes back to the microcrystalline gel spontaneously as the field is switched off. Computer simulations show that even a very small polydispersity destabilizes ordered periodic structures that would have been stable in a monodisperse system.
Microwave-assisted preparation of self-doped TiO2 nanotube arrays for enhanced photoelectrochemical water splitting
Authors: Li Hui , Chen Jiangqiong , Xia Zhengbin , Xing Junheng
Published: November 2014

Bulk abundant Ti3+ self-doped TiO2 nanotube arrays are prepared by a microwave-assisted chemical reduction method with NaBH4.
Enhancement of thermoelectric properties of Yb-filled skutterudites by an Ni-Induced “core–shell” structure
Authors: Fu Liangwei , Yang Junyou , Peng Jiangying , Jiang Qinghui , Xiao Ye , Luo Yubo , Zhang Dan , Zhou Zhiwei , Zhang Mingyang , Cheng Yudong , Cheng Fuqiang
Published: November 2014

For the first time, we introduced a “core–shell” microstructure into Yb single-filled skutterudite thermoelectric materials by Ni doping.
Reaction pathway and wiring network dependent Li/Na storage of micro-sized conversion anode with mesoporosity and metallic conductivity
Authors: Cui Zhonghui , Li Chilin , Yu Pengfei , Yang Minghui , Guo Xiangxin , Yin Congling
Published: November 2014

Highly mesoporous and conductive micro-sized nitride is used as potential conversion LIB and NIB anodes. Superior rate and cycling performances (e.g. 600 mA h g−1 and 100 mA h g−1 at 2 C for Li- and Na-storage, respectively) benefit from self-reconstruction and preservation of conductive networks.
Effects of fluorine on the structure of fluorohydroxyapatite: a study by XRD, solid-state NMR and Raman spectroscopy
Authors: Chen Jinshuai , Yu Zhiwu , Zhu Peizhi , Wang Junfeng , Gan Zhehong , Wei Jie , Zhao Yinghui , Wei Shicheng
Published: November 2014

An atomic snapshot of fluorohydroxyapatites with different fluorine contents by solid state NMR.
A salt-assisted acid etching strategy for hollow mesoporous silica/organosilica for pH-responsive drug and gene co-delivery
Authors: Wu Meiying , Chen Yu , Zhang Lingxia , Li Xiaoyu , Cai Xiaojun , Du Yanyan , Zhang Linlin , Shi Jianlin
Published: November 2014

Hollow mesoporous organosilica nanoparticles have been developed by a salt-assisted acid etching strategy and employed to co-deliver DOX and shRNA.
Self-assembly of metal ion induced highly emissive fluorophore-triphenylamine nanostructures: enhanced two-photon action cross-section for bioimaging applications
Authors: Kong Lin , Tian Yu-peng , Chen Qi-yu , Zhang Qiong , Wang Hui , Tan Dong-qin , Xue Zhao-ming , Wu Jie-ying , Zhou Hong-ping , Yang Jia-xiang
Published: November 2014

Metal induced self-aggregation of an AIEE type TPA material enhanced the two-photon action cross-section for bioimaging in HepG2 cells.
Preparation of structurally colored, monodisperse spherical assemblies composed of black and white colloidal particles using a micro-flow-focusing device
Authors: Teshima Midori , Seki Takahiro , Kawano Ryuji , Takeuchi Shoji , Yoshioka Shinya , Takeoka Yukikazu
Published: November 2014

Monodisperse-spherical-assemblies displaying various structural-colors in air can be prepared from white and black colloidal particles using a micro-flow-focusing device.
Red emissive diarylboron diketonate crystals: aggregation-induced color change and amplified spontaneous emission
Authors: Wang Lu , Zhang Zhenyu , Cheng Xiao , Ye Kaiqi , Li Feng , Wang Yue , Zhang Hongyu
Published: November 2014

The present study not only provides a rare example of organic crystals with highly efficient red fluorescence but also indicates the possible application of four-coordinate boron materials in organic solid-state lasers.
Two-step-route to Ag–Au nanoparticles grafted on Ge wafer for extra-uniform SERS substrates
Authors: Wang Tao , Hu Fei , Ikhile Emmanuel , Liao Fan , Li Yanqing , Shao Mingwang
Published: November 2014

Ag–Au nanoparticles grafted on Ge wafer were fabricated as SERS substrates to detect 200 random spots and the lowest relative standard deviation of less than 7% was obtained.
Thienoisoindigo-based copolymer with fused thieno[3,2-b]thiophene as a donor in thin film transistor applications with high performance
Authors: Chen Chi-Min , Sharma Sunil , Li Yi-Lun , Lee Jey-Jau , Chen Show-An
Published: November 2014

A thienoisoindigo-based copolymer with thieno[3,2-b]thiophene as a donor shows a temperature-dependent orientation of its chains, and a hole mobility up to 0.69 cm2 V−1 s−1 has been achieved.
The Hepatic Reductase Null (HRN™) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants
Authors: Arlt Volker M. , Henderson Colin J. , Wolf C. Roland , Stiborová Marie , Phillips David H.
Published: November 2014

This review describes the applicability of the Hepatic Reductase Null (HRN) and Reductase Conditional Null (RCN) mouse models to study carcinogen metabolism.
The structural basis of DNA binding by the single-stranded DNA-binding protein from Sulfolobus solfataricus
Authors: Gamsjaeger Roland , Kariawasam Ruvini , Gimenez Adrian X. , Touma Christine , McIlwain Elysse , Bernardo Ray E. , Shepherd Nicholas E. , Ataide Sandro F. , Dong Qihan , Richard Derek J. , White Malcolm F. , Cubeddu Liza
Published: November 2014

Canonical single-stranded DNA-binding proteins (SSBs) from the oligosaccharide/oligonucleotide-binding (OB) domain family are present in all known organisms and are critical for DNA replication, recombination and repair. The SSB from the hyperthermophilic crenarchaeote Sulfolobus solfataricus (SsoSSB) has a ‘simple’ domain organization consisting of a single DNA-binding OB fold coupled to a flexible C-terminal tail, in contrast with other SSBs in this family that incorporate up to four OB domains. Despite the large differences in the domain organization within the SSB family, the structure of the OB domain is remarkably similar all cellular life forms. However, there are significant differences in the molecular mechanism of ssDNA binding. We have determined the structure of the SsoSSB OB domain bound to ssDNA by NMR spectroscopy. We reveal that ssDNA recognition is modulated by base-stacking of three key aromatic residues, in contrast with the OB domains of human RPA and the recently discovered human homologue of SsoSSB, hSSB1. We also demonstrate that SsoSSB binds ssDNA with a footprint of five bases and with a defined binding polarity. These data elucidate the structural basis of DNA binding and shed light on the molecular mechanism by which these ‘simple’ SSBs interact with ssDNA.
Anaemia in chronic obstructive pulmonary disease: an insight into its prevalence and pathophysiology
Authors: Boutou Afroditi K. , Hopkinson Nicholas S. , Polkey Michael I.
Published: November 2014

Chronic obstructive pulmonary disease (COPD) is a major health problem, with increasing morbidity and mortality. There is a growing literature regarding the extra-pulmonary manifestations of COPD, which can have a significant impact on symptom burden and disease progression. Anaemia is one of the more recently identified co-morbidities, with a prevalence that varies between 4.9% and 38% depending on patient characteristics and the diagnostic criteria used. Systemic inflammation seems to be an important factor for its establishment and repeated bursts of inflammatory mediators during COPD exacerbations could further inhibit erythropoiesis. However, renal impairment, malnutrition, low testosterone levels, growth hormone level abnormalities, oxygen supplementation, theophylline treatment, inhibition of angiotensin-converting enzyme and aging itself are additional factors that could be associated with the development of anaemia. The present review evaluates the published literature on the prevalence and significance of anaemia in COPD. Moreover, it attempts to elucidate the reasons for the high variability reported and investigates the complex pathophysiology underlying the development of anaemia in these patients.
Altered profile of circulating microparticles in rheumatoid arthritis patients
Authors: Rodríguez-Carrio Javier , Alperi-López Mercedes , López Patricia , Alonso-Castro Sara , Carro-Esteban Santiago R. , Ballina-García Francisco J. , Suárez Ana
Published: November 2014

Microparticles (MPs) could be considered biomarkers of cell damage and activation as well as novel signalling structures. Since rheumatoid arthritis (RA) is characterized by immune and endothelial activation, the main aim of the present study was to analyse MP counts in RA patients. Citrated-blood samples were obtained from 114 RA patients, 33 healthy controls (HC) and 72 individuals with marked cardiovascular (CV) risk without autoimmune manifestations (CVR). MPs were analysed in platelet-poor plasma (PPP) and different subsets were identified by their surface markers: platelet- (CD41+), endothelial- (CD146+), granulocyte- (CD66+), monocyte- (CD14+) and Tang- (CD3+CD31+) derived. Disease activity score (DAS28), clinical and immunological parameters as well as traditional CV risk factors (diabetes, hypertension, dyslipidaemia and obesity) were registered from clinical records and all data were integrated using Principal Component Analysis (PCA). Absolute MP number was increased in RA patients compared with HC and positively correlated with traditional CV risk factors, similar to that of CVR subjects. In addition, frequency of the different MP subsets was different in RA patients and significantly associated with disease features. Moreover, in vitro assays revealed that MPs isolated from RA patients were able to promote endothelial activation and exhibited detrimental effects on human microvascular endothelial cells (HMEC-I) endothelial cell functionality. Circulating MPs from RA patients displayed quantitative and qualitative alterations that are the result of both disease-specific and traditional CV risk factors. Accordingly, this MP pool exhibited in vitro detrimental effects on endothelial cells, thus supporting their role as biomarkers of vascular damage.
Favorable Effects of Vitamin D Supplementation on Pregnancy Outcomes in Gestational Diabetes: A Double Blind Randomized Controlled Clinical Trial
Authors: Asemi Z. , Karamali M. , Esmaillzadeh A.
Published: November 2014

Gestational diabetes mellitus (GDM) has been recognized as a significant risk factor for unfavorable pregnancy outcomes. Prevalence of vitamin D deficiency is highly prevalent among women with GDM. This study was designed to assess the effect of vitamin D supplementation on pregnancy outcomes of pregnant women with GDM who were not on oral hypoglycemic agents. This randomized controlled clinical trial was performed among 45 pregnant women diagnosed with GDM at 24–28 weeks’ gestation. Subjects were randomly assigned to consume either vitamin D supplements (cholecalciferol) or placebo. Individuals in the vitamin D group (n=22) received 50 000 IU vitamin D3 pearl 2 times during the study: at study baseline and day 21 of intervention and those in placebo group (n=23) received 2 placebos at the mentioned times. Fasting blood samples were taken at baseline to measure fasting plasma glucose. Participants underwent a 3-h oral glucose tolerance tests (OGTT) and the blood samples were collected at time 60, 120, and 180 min to measure plasma glucose levels. Newborn’s weight, height, head circumference, Apgar score, and hyperbilirubinemia were determined. Taking vitamin D supplements, compared with placebo, resulted in improved pregnancy outcomes; such that those in the vitamin D group had no case of polyhydramnios, while 17.4% of subjects in placebo group had this condition (p=0.04). In addition, newborn’s hyperbilirubinemia was significantly lower in vitamin D group than that in placebo group (27.3% vs. 60.9%, p=0.02). In conclusion, vitamin D supplementation for 6 weeks among pregnant women with GDM resulted in decreased maternal polyhydramnios and infant hyperbilirubinemia compared with placebo.

Clinical trial registration number

www.irct.ir:IRCT201305115623N7.
Gamma-ray momentum reconstruction from Compton electron trajectories by filtered back-projection
Authors: Haefner A. , Gunter D. , Plimley B. , Pavlovsky R. , Vetter K.
Published: November 2014

Gamma-ray imaging utilizing Compton scattering has traditionally relied on measuring coincident gamma-ray interactions to map directional information of the source distribution. This coincidence requirement makes it an inherently inefficient process. We present an approach to gamma-ray reconstruction from Compton scattering that requires only a single electron tracking detector, thus removing the coincidence requirement. From the Compton scattered electron momentum distribution, our algorithm analytically computes the incident photon's correlated direction and energy distributions. Because this method maps the source energy and location, it is useful in applications, where prior information about the source distribution is unknown. We demonstrate this method with electron tracks measured in a scientific Si charge coupled device. While this method was demonstrated with electron tracks in a Si-based detector, it is applicable to any detector that can measure electron direction and energy, or equivalently the electron momentum. For example, it can increase the sensitivity to obtain energy and direction in gas-based systems that suffer from limited efficiency.
Thermodynamic aspects of dehydrogenation reactions on noble metal surfaces
Authors: Svane K. L. , Hammer B.
Published: November 2014

The reaction free energy for dehydrogenation of phenol, aniline, thiophenol, benzoic acid, and 1,4-benzenediol on the close packed copper, silver, and gold surfaces has been studied by density functional theory calculations. Dehydrogenation of thiophenol is found to be favourable on all three surfaces while aniline does not dehydrogenate on any of them. For phenol, benzenediol and benzoic acid dehydrogenation is favourable on copper and silver only, following the general trend of an increasing reaction free energy when going form gold to silver to copper. This trend can be correlated with the changes in bond lengths within the molecule upon dehydrogenation. While copper is able to replace hydrogen, leaving small changes in the bond lengths of the aromatic ring, the metal-molecule bond is weaker for silver and gold, resulting in a partial loss of aromaticity. This difference in bond strength leads to pronounced differences in adsorption geometries upon multiple dehydrogenations.
Quantum chemical approach for condensed-phase thermochemistry: Proposal of a harmonic solvation model
Authors: Nakai Hiromi , Ishikawa Atsushi
Published: November 2014

We propose a novel quantum chemical method, called the harmonic solvation model (HSM), for calculating thermochemical parameters in the condensed phase, particularly in the liquid phase. The HSM represents translational and rotational motions of a solute as vibrations interacting with a cavity wall of solvent molecules. As examples, the HSM and the ideal-gas model (IGM) were used for the standard formation reaction of liquid water, combustion reactions of liquid formic acid, methanol, and ethanol, vapor–liquid equilibration of water and ethanol, and dissolution of gaseous CO2 in water. The numerical results confirmed the reliability and applicability of the HSM. In particular, the temperature dependence of the Gibbs energy of liquid molecules was accurately reproduced by the HSM; for example, the boiling point of water was reasonably determined using the HSM, whereas the conventional IGM treatment failed to obtain a crossing of the two Gibbs energy curves for gaseous and liquid water.
High resolution coherent diffractive imaging with a table-top extreme ultraviolet source
Authors: Vu Le Hoang , Ba Dinh Khuong , Hannaford Peter , Van Dao Lap
Published: November 2014

We demonstrate a resolution of 45 nm with a sample size down to 3 μm × 3 μm is achieved in a short exposure time of 2 s, from the diffraction pattern generated by a table-top high harmonic source at around 30 nm. By using a narrow-bandwidth focusing mirror, the diffraction pattern's quality is improved and the required exposure time is significantly reduced. In order to obtain a high quality of the reconstructed image, the ratio of the beam size to the sample size and the curvature of the focused beam need to be considered in the reconstruction process. This new experimental scheme is very promising for imaging sub-10 nm scale objects with a table-top source based on a small inexpensive femtosecond laser system.
Microwave eddy-current shielding effect in metallic films and periodic nanostructures of sub-skin-depth thicknesses and its impact on stripline ferromagnetic resonance spectroscopy
Authors: Maksymov Ivan S. , Kostylev Mikhail
Published: November 2014

A strong microwave shielding effect due to the excitation of microwave eddy-currents exists for metallic films of sub-skin-depth thickness (10–100 nm). If the film is ferromagnetic, this effect strongly influences results of the broadband stripline ferromagnetic resonance (FMR) spectroscopy. It also potentially hampers the development of magnetically tuneable metamaterials. By means of rigorous numerical simulations, we address an important problem of the dependence of the eddy current effect on the width of the stripline used for driving magnetisation dynamics in the broadband FMR spectroscopy. We study theoretically electrodynamics of realistic striplines and also extend the main result from the case of continuous conductive films to periodic conductive nanostructures—magnonic crystals. Based on these findings, we also give recommendations on improving performance of magnetically tuneable metamaterials, which are based on conductive ferromagnetic films and nanostructures. In our simulations, we consider examples of microstrip lines which are 5 μm to 1.5 mm wide. However, the simulation results should be equally applicable to coplanar waveguides with the same width of the signal line.
Study of narrowband single photon emitters in polycrystalline diamond films
Authors: Sandstrom Russell G. , Shimoni Olga , Martin Aiden A. , Aharonovich Igor
Published: November 2014

Quantum information processing and integrated nanophotonics require robust generation of single photon emitters on demand. In this work, we demonstrate that diamond films grown on a silicon substrate by microwave plasma chemical vapor deposition can host bright, narrowband single photon emitters in the visible—near infra-red spectral range. The emitters possess fast lifetime (∼several ns), absolute photostability, and exhibit full polarization at excitation and emission. Pulsed and continuous laser excitations confirm their quantum behaviour at room temperature, while low temperature spectroscopy is performed to investigate inhomogeneous broadening. Our results advance the knowledge of solid state single photon sources and open pathways for their practical implementation in quantum communication and quantum information processing.
Scattering mechanical performances for brittle bulk metallic glasses
Authors: Qiao J. W. , Meng M. M. , Wang Z. H. , Huang C. J. , Li R. , Wang Y. S. , Yang H. J. , Zhang Y. , Li L. F.
Published: November 2014

Scattering mechanical performances of brittle La- and Mg-based BMGs are found in the present study. Upon dynamic loading, there exist largely scattered fracture strengths even if the strain rates are under the same order, and the BMG systems are the same. The negative strain rate dependence for La- and Mg-based BMGs is obtained, i.e., a decreased fracture strength is dominating from quasi-static to dynamic compression. At cryogenic temperatures, distinguishingly low fracture strengths are available for these two brittle BMGs, and decreased tolerance to accommodate strains makes BMGs more and more brittle. It is concluded that the scattering mechanical performances of brittle BMGs should be carefully evaluated before actual applications.
Amelioration of alkaline phytotoxicity by lowering soil pH
Authors: Brautigan D. J. , Rengasamy P. , Chittleborough D. J.
Published: November 2014

Highly alkaline soils (pH >9) may adversely affect agricultural crop productivity. At pH >9.2, aluminium (Al) phytotoxicity may further retard plant development. Most alkaline soils have little alkaline buffering capacity, making it feasible to use acid to lower soil pH to <9.2. Many methods of lowering soil pH have been trialled; however, little research has been done on their relative effectiveness and longevity. Methods trialled in this study as means of lowering soil pH were chemical additives (gypsum), organic additives (glucose, molasses, horse manure, green manure, humus) and leguminous plants. Gypsum was also used in conjunction with plants to determine any synergistic effects of combining treatments. All ameliorants trialled except humus and horse manure proved effective at lowering soil pH to <9.2. The reduction achieved with biological amendments was temporary, with pH returning to pre-amendment levels over the course of the study. Gypsum was most effective amendment for lowering soil pH and sustaining the lowered pH level. The use of plants to lower soil pH, in conjunction with gypsum to sustain the lowered pH, may be an effective and economic method of remediating Al phytotoxicity in alkaline soils.