bluuebunny/crossref_metadata_2025 huggingface dataset:
Metabolic and transcriptomic response of two juvenile anadromous brook charr (Salvelinus fontinalis) genetic lines towards a chronic thermal stress
Authors: Jourdain-Bonneau Christophe , Deslauriers David , Gourtay Clémence , Jeffries Kenneth M. , Audet C.
Published: June 2023

Many salmonid species are particularly susceptible to chronic and acute temperature changes caused by global warming. We aimed to study the differences in metabolic and transcriptomic responses of a chronic heat stress on a control and selected (absence of early sexual maturation and growth) line of brook charr Salvelinus fontinalis (Mitchill, 1814). We exposed individuals to different temperatures for 35 days (15, 17, and 19 °C). High temperature reduced the growth rate (in length) and the Fulton condition factor. Both maximal metabolic rate and the aerobic scope were higher in fish reared at 17 °C, while they decreased in fish maintained at 19 °C. The relative gene expression of cytochrome c oxidase was lower at 19 °C than at 15 °C. The relative gene expressions of both liver and gill hsp90 was higher at the highest temperature. The standard metabolic rate, while not affected by temperature, was higher for the control line over the selected line. Only in the control line, the relative expression of catalase and of receptor of insulin-like growth factor-1 increased at 19 °C. Our results showed that the selected line was able to cope more effectively with the oxidative stress caused by the rise in temperature.
Co-management at a crossroads in Canada: issues, opportunities, and emerging challenges in fisheries and marine contexts
Authors: Swerdfager T. , Armitage D.
Published: June 2023

Despite some progress, successful co-management in Canada has remained the exception rather than the rule, and especially so in jurisdictions not covered by a comprehensive land claims agreement. As such, our aim in this perspective is to identify and describe some of the primary factors that may impede more rapid progress toward successful co-management and to explore why they persist, with particular attention to fisheries and marine contexts. Specifically, we outline several institutional conditions that are likely to impede broader adoption of co-management approaches in Canada, including (1) antiquated and incomplete legislative arrangements; (2) a co-management policy vacuum that has not grappled with emerging expectations for co-governance; (3) relative absence of the knowledge co-production systems needed to create the precursors for successful co-management initiatives; and (4) financial and human resource capacity limitations. Such conditions must also be situated in a dynamic context that includes the United Nations Declaration of the Rights of Indigenous Peoples, ongoing reconciliation processes, and shifts in the ownership and use of fisheries and other marine resources. We offer, finally, some suggestions to augment co-management efforts and ultimately achieve its promise.
The effect of cations in electronic, and optical properties of lead-free halide perovskites based on Sn–Ge
Authors: Khademi Tahmineh , Movlarooy Tayebeh
Published: June 2023

In this work, the electronic and optical properties of three-dimensional (3D) lead-free hybrid perovskites [Formula: see text][Formula: see text] with organic and inorganic cations [Formula: see text], Cs ([Formula: see text]) have been investigated using density functional theory (DFT). The nature of the cations in the 3D perovskite structure has a significant impact on the electronic and optical properties of the 3D structures because octahedral [Formula: see text] is so sensitive to them. The results revealed that by replacing the organic cation with the inorganic cation, the band gap has increased, and also in the optical properties, an increase in the absorption coefficient and a decrease in reflection have been observed. According to the obtained results, the [Formula: see text] compound is a better candidate for optoelectronic devices and solar cells applications than [Formula: see text], due to its higher band gap, higher absorption coefficient, lower reflection, and cheaper price. These findings are crucial for comprehending how cations affect lead-free perovskite halides, and we hope it will be a useful guide for improving the photovoltaic efficiency of lead-free perovskite solar cells. In addition to the absorber layer of solar cells, 3D perovskites are used in laser and thermoelectric applications, topological insulation, and radiation detection.
Constructing Faithful Homomorphisms over Fields of Finite Characteristic
Authors: Chatterjee Prerona , Saptharishi Ramprasad
Published: June 2023

We study the question of algebraic rank or transcendence degree preserving homomorphisms over finite fields. This concept was first introduced by Beecken et al. [
3
] and exploited by them, and Agrawal et al. [
2
] to design algebraic independence–based identity tests using the Jacobian criterion over characteristic zero fields. An analogue of such constructions over finite characteristic fields was unknown due to the failure of the Jacobian criterion over finite characteristic fields.

Building on a recent criterion of Pandey et al. [
15
], we construct explicit faithful maps for some natural classes of polynomials in the positive characteristic field setting, when a certain parameter called the
inseparable degree
of the underlying polynomials is bounded (this parameter is always 1 in fields of characteristic zero). This presents the first generalisation of some of the results of Beecken et al. [
3
] and Agrawal et al. [
2
] in the positive characteristic setting.
The Recent Wave of Generative AI Systems: What Does This Tell Us About What AI Can Do Now?
Authors: El-Deeb Ahmed
Published: June 2023

No, this paper content is not generated by AI. Not sure if that question came across my editor's mind while reviewing submissions. It's a rightful question nowadays after the wave of generative AI apps that swamped our lives between chatGPT to King Charles coronation afterparty videos. Finally, AI is here in our hands that everyone of us can touch and integrate in daily life; after long being a fancy research topic. The question now is how this is going to shape our industry? Or more proactively, how generative AI can help us improve our craft and processes. This paper surveys key areas where generative AI can help us shape our industry and the way we work.
A Data-centric AI Framework for Automating Exploratory Data Analysis and Data Quality Tasks
Authors: Patel Hima , Guttula Shanmukha , Gupta Nitin , Hans Sandeep , Mittal Ruhi Sharma , N Lokesh
Published: June 2023

Democratisation of machine learning (ML) has been an important theme in the research community for the last several years with notable progress made by the model-building community with automated machine learning models. However, data play a central role in building ML models and there is a need to focus on data-centric AI innovations. In this article, we first map the steps taken by data scientists for the data preparation phase and identify open areas and pain points via user interviews. We then propose a framework and four novel algorithms for exploratory data analysis and data quality for AI steps addressing the pain points from user interviews. We also validate our algorithms with open source datasets and show the effectiveness of our proposed methods. Next, we build a tool that automatically generates python code encompassing the above algorithms and study the usefulness of these algorithms via two user studies with data scientists. We observe from the first study results that the participants who used the tool were able to gain 2× productivity and  6% model improvement over the control group. The second study is performed in a more realistic environment to understand how the tool would be used in real-world scenarios. The results from this study are coherent with the first study and show an average of 30–50% of time savings that can be attributed to the tool.
Repair of an Extensive External Cervical Resorption Lesion Using Intentional Replantation with Crown Rotation
Authors: Okamoto Motoki , Asahi Yoko , Duncan Henry Fergus , Kuriki Nanako , Takahashi Yusuke , Hayashi Mikako
Published: June 2023

Treatment of large external cervical resorption (ECR) lesions may be compromised, rendering the tooth unrestorable. Intentional replantation is a potential treatment option depending on the site and extent of ECR. We present a case of a large ECR successfully managed with intentional replantation with rotation of the tooth. The female patient consulted the hospital clinic, with an extensive palatal ECR on the maxillary lateral incisor. Routine planar radiographs and cone-beam computed tomography demonstrated a larger palatal than the ECR lesion (Heithersay Class III and Patel’s Class 2Bp) not amenable to nonsurgical treatment. Intentional replantation after short-term extrusion was planned. The defect was restored, then a palatal ferrule was achieved by rotating the tooth by 180°. At the 18-month follow-up, the periradicular and periodontal tissues remained healthy, and no other symptoms were reported. In conclusion, this successful video-illustrated clinical case highlights the benefits of intentional replantation in saving teeth with advanced ECR.
Potential Assessment and Economic Analysis of Concentrated Solar Power against Solar Photovoltaic Technology
Authors: Orangzeb Sahil , Qaisrani Mumtaz A. , Shafiq M. Basit , Ahmed N. , Sahar M. Sana Ullah , Ullah Sana , Farooq Muhammad Umer , Jiabin Fang
Published: June 2023

Competition between concentrated solar power and solar photovoltaic has been the subject of frequent debate in recent years based on their cost of fabrication, efficiency, storage, levelized cost of energy, reliability, and complexity of respective technologies. Taking Pakistan as a testbed, a study was conducted to determine which technology is economical in a particular location and climate. The study assesses the meteorological, orographic, and spatial factors that impact the performance and cost of both renewable energy systems. A SWOT analysis, followed by technoeconomic analyses, was conducted to determine suitable sites for setting up solar power plants in Pakistan. A detailed assessment of siting factors for solar power plants was conducted to shortlist the most suitable sites. Based on the results, economic analysis was performed to install 100 MW photovoltaic and parabolic trough power plants at selected locations. The levelized cost of energy for the 100 MW parabolic trough is 10.8 cents/kWh and 12 cents/kWh in best-case scenarios, i.e., for locations of Toba and Quetta, respectively, whereas the LCOEs of 100 MW photovoltaic systems stand comparatively low at 7.36 cents/kWh, 7.21 cents/kWh, 7.01 cents/kWh, 6.82 cents/kWh, 6.02 cents/kWh, and 5.95 cents/kWh in Multan, Bahawalpur, Rahim Yar Khan, Hyderabad, Quetta, and Toba, respectively. The results favor choosing solar PV plants over solar CSP plants in terms of finances in the selected regions. The findings will assist financiers and policymakers in creating better policies in terms of long-term goals.
Psychosocial Problems among Psychiatric Nurses for Caring Patients with Mental Disorders during the COVID-19 Pandemic
Authors: Rahmat Ibrahim , Pawestri Fajar , Saputro Ragil Aji , Widianingrum Setiyati , Hanifah Triana
Published: June 2023

COVID-19 has a negative effect on the psychological well-being of psychiatric nurses. Thus, examining the psychosocial response of nurses is important for preventing more serious mental health problems and disruption of the quality of nursing care. This study aimed to evaluate the psychosocial problems of nurses who provided nursing care to patients with mental health disorders during the COVID-19 pandemic. A quantitative study with a cross-sectional design was conducted. The 101 nurses at Central Mental Health Hospital who provide nursing care to patients with mental health disorders were recruited through consecutive sampling. The instruments used were the demographic questionnaire, the Expanded Nursing Stress Scale, Zung Self-Rating Anxiety Scale, and The Connor–Davidson Resilience Scale 25. Univariate and bivariate analyses were used to process the data. The mean score of 45.1 (±24.3) was obtained for the ENSS; around 97% of nurses have a work stress score below the average, 4.95% have mild-moderate anxiety, and 28.7% have a low level of resilience. Work stress and contact frequency, work stress and gender, anxiety and contact frequency, as well as resilience and contact frequency all correlated significantly (

p

value <0.05). The Pearson test showed a significant positive correlation between work stress and anxiety (

p

: 0.002, r: 0.299). However, there was no significant correlation between anxiety and resilience (

p

: 0.643, r: 0.47), nor between work stress and resilience (

p

: 0.643; r: 0.47). Psychosocial disorders that psychiatric nurses face include occupational stress, mild-moderate anxiety, and low resilience. The government can create specific infection control guidelines for the mental health setting, and hospital management or ward leaders can also provide support to psychiatric nurses to increase resilience in reducing psychosocial problems.
Comparison of Pregnancy Outcome between 4 and 6 cm Cervical os Dilatation to Demarcate Active Phase of Labour: A Cross-Sectional Study
Authors: Mohd Fathil Nadzirah , Abd Rahman Rahana , Mohd Nawi Azmawati , Kamisan Atan Ixora , Kalok Aida Hani , Mohamed Ismail Nor Azlin , Abdullah Mahdy Zaleha , Masra Farin , Muhammad Zuhailah , Ahmad Shuhaila
Published: June 2023

This is a cross-sectional study comparing pregnancy outcomes between participants with 4 and 6 cm of cervical os dilatation at the diagnosis of the active phase of labour. It was conducted in a single tertiary centre involving low-risk singleton pregnancies at or beyond 37 weeks with spontaneous onset of labour. A total of 155 participants were recruited, 101 in group 1 (4 cm) and 54 in group 2 (6 cm). Both groups were similar in mean maternal age, mean gestational age at delivery, ethnicity, median haemoglobin level at delivery, body mass index, and parity. There were significantly more participants in group 1 who needed oxytocin augmentation (

p
<
0.001

) for the longer mean duration (

p
=
0.015

), use of analgesia (

p
<
0.001

), and caesarean section rate (

p
=
0.002

). None of the women had a postpartum haemorrhage or a third- or fourth-degree perineal tear, and none of the neonates required admission to the neonatal intensive care unit. There were significantly more nulliparas who had a caesarean section as compared to multiparas. A cervical os dilatation of 6 cm reduces the risk of caesarean section by 11% (95% CI, 0.01-0.9) and increases three times more the need for analgesia (

AOR
=
3.44

, 95% CI, 1.2-9.4). In conclusion, the demarcation of the active phase of labour at a cervical os dilatation of 6 cm is feasible without an increase in maternal or neonatal complications.
Supplementary Table S4 from C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3-Mutant Leukemia
Authors: Sabatier Marie , Birsen Rudy , Lauture Laura , Mouche Sarah , Angelino Paolo , Dehairs Jonas , Goupille Léa , Boussaid Ismael , Heiblig Maël , Boet Emeline , Sahal Ambrine , Saland Estelle , Santos Juliana C. , Armengol Marc , Fernández-Serrano Miranda , Farge Thomas , Cognet Guillaume , Simonetta Federico , Pignon Corentin , Graffeuil Antoine , Mazzotti Céline , Avet-Loiseau Hervé , Delos Océane , Bertrand-Michel Justine , Chedru Amélie , Dembitz Vilma , Gallipoli Paolo , Anstee Natasha S. , Loo Sun , Wei Andrew H. , Carroll Martin , Goubard Armelle , Castellano Rémy , Collette Yves , Vergez François , Mansat-De Mas Véronique , Bertoli Sarah , Tavitian Suzanne , Picard Muriel , Récher Christian , Bourges-Abella Nathalie , Granat Fanny , Kosmider Olivier , Sujobert Pierre , Colsch Benoit , Joffre Carine , Stuani Lucille , Swinnen Johannes V. , Guillou Hervé , Roué Gael , Hakim Nawad , Dejean Anne S. , Tsantoulis Petros , Larrue Clément , Bouscary Didier , Tamburini Jerome , Sarry Jean-Emmanuel
Published: June 2023

Table S4: GSEA results in FLT3-ITD PDX AML cells ex vivo-treated with QUIZ or Veh.
Supplementary Table S3 from C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3-Mutant Leukemia
Authors: Sabatier Marie , Birsen Rudy , Lauture Laura , Mouche Sarah , Angelino Paolo , Dehairs Jonas , Goupille Léa , Boussaid Ismael , Heiblig Maël , Boet Emeline , Sahal Ambrine , Saland Estelle , Santos Juliana C. , Armengol Marc , Fernández-Serrano Miranda , Farge Thomas , Cognet Guillaume , Simonetta Federico , Pignon Corentin , Graffeuil Antoine , Mazzotti Céline , Avet-Loiseau Hervé , Delos Océane , Bertrand-Michel Justine , Chedru Amélie , Dembitz Vilma , Gallipoli Paolo , Anstee Natasha S. , Loo Sun , Wei Andrew H. , Carroll Martin , Goubard Armelle , Castellano Rémy , Collette Yves , Vergez François , Mansat-De Mas Véronique , Bertoli Sarah , Tavitian Suzanne , Picard Muriel , Récher Christian , Bourges-Abella Nathalie , Granat Fanny , Kosmider Olivier , Sujobert Pierre , Colsch Benoit , Joffre Carine , Stuani Lucille , Swinnen Johannes V. , Guillou Hervé , Roué Gael , Hakim Nawad , Dejean Anne S. , Tsantoulis Petros , Larrue Clément , Bouscary Didier , Tamburini Jerome , Sarry Jean-Emmanuel
Published: June 2023

Table S3: Clinical characteristics of samples from patients with AML used in PDX assays
Supplementary Table S11 from C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3-Mutant Leukemia
Authors: Sabatier Marie , Birsen Rudy , Lauture Laura , Mouche Sarah , Angelino Paolo , Dehairs Jonas , Goupille Léa , Boussaid Ismael , Heiblig Maël , Boet Emeline , Sahal Ambrine , Saland Estelle , Santos Juliana C. , Armengol Marc , Fernández-Serrano Miranda , Farge Thomas , Cognet Guillaume , Simonetta Federico , Pignon Corentin , Graffeuil Antoine , Mazzotti Céline , Avet-Loiseau Hervé , Delos Océane , Bertrand-Michel Justine , Chedru Amélie , Dembitz Vilma , Gallipoli Paolo , Anstee Natasha S. , Loo Sun , Wei Andrew H. , Carroll Martin , Goubard Armelle , Castellano Rémy , Collette Yves , Vergez François , Mansat-De Mas Véronique , Bertoli Sarah , Tavitian Suzanne , Picard Muriel , Récher Christian , Bourges-Abella Nathalie , Granat Fanny , Kosmider Olivier , Sujobert Pierre , Colsch Benoit , Joffre Carine , Stuani Lucille , Swinnen Johannes V. , Guillou Hervé , Roué Gael , Hakim Nawad , Dejean Anne S. , Tsantoulis Petros , Larrue Clément , Bouscary Didier , Tamburini Jerome , Sarry Jean-Emmanuel
Published: June 2023

Table S11
Supplementary Table S1 from Mitochondrial-Encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hürthle Cell Carcinoma of the Thyroid
Authors: Frank Anderson R. , Li Vicky , Shelton Spencer D. , Kim Jiwoong , Stott Gordon M. , Neckers Leonard M. , Xie Yang , Williams Noelle S. , Mishra Prashant , McFadden David G.
Published: June 2023

Supplementary Table S1 shows key mtDNA mutations identified through whole-exome sequencing and targeted mtDNA sequencing.
Supplementary Tables 1-3, 7-9 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities
Authors: McNicholas Michael , De Cola Antonella , Bashardanesh Zahedeh , Foss Amelia , Lloyd Cameron B. , Hébert Steven , Faury Damien , Andrade Augusto Faria , Jabado Nada , Kleinman Claudia L. , Pathania Manav
Published: June 2023

Tables describing statistical analyses, median survivals, IC50 values calculated from cell viability assays, primer sequences and antibodies.
Supplementary Table 2 from NCI 7977: A Phase I Dose-Escalation Study of Intermittent Oral ABT-888 (Veliparib) plus Intravenous Irinotecan Administered in Patients with Advanced Solid Tumors
Authors: Cecchini Michael , Walther Zenta , Wei Wei , Hafez Navid , Pilat Mary Jo , Boerner Scott A. , Durecki Diane E. , Eder Joseph P. , Schalper Kurt A. , Chen Alice P. , LoRusso Patricia
Published: June 2023

A full list of all adverse events.
Figure S5 from Immunological characterization and T-cell receptor repertoires of expanded tumor-infiltrating lymphocytes in renal cell carcinoma patients
Authors: Lee Moon Hee , Theodoropoulos Jason , Huuhtanen Jani , Bhattacharya Dipabarna , Järvinen Petrus , Tornberg Sara , Nísen Harry , Mirtti Tuomas , Uski Ilona , Kumari Anita , Peltonen Karita , Draghi Arianna , Donia Marco , Kreutzman Anna , Mustjoki Satu
Published: June 2023

Figure S5 shows representative gating strategies for the co-culture assays with different timepoints (6h, 48h) and conditions (baseline, unstimulated, T-cell stimulated).
Figure S4 from Immunological characterization and T-cell receptor repertoires of expanded tumor-infiltrating lymphocytes in renal cell carcinoma patients
Authors: Lee Moon Hee , Theodoropoulos Jason , Huuhtanen Jani , Bhattacharya Dipabarna , Järvinen Petrus , Tornberg Sara , Nísen Harry , Mirtti Tuomas , Uski Ilona , Kumari Anita , Peltonen Karita , Draghi Arianna , Donia Marco , Kreutzman Anna , Mustjoki Satu
Published: June 2023

Figure S4 shows representative gating strategies for the different marker expressions in the CD4+ and CD8+ T-cells for the different samples (healthy kidney, tumor, pre-REP TIL and REP TIL).
Figure S2 from Immunological characterization and T-cell receptor repertoires of expanded tumor-infiltrating lymphocytes in renal cell carcinoma patients
Authors: Lee Moon Hee , Theodoropoulos Jason , Huuhtanen Jani , Bhattacharya Dipabarna , Järvinen Petrus , Tornberg Sara , Nísen Harry , Mirtti Tuomas , Uski Ilona , Kumari Anita , Peltonen Karita , Draghi Arianna , Donia Marco , Kreutzman Anna , Mustjoki Satu
Published: June 2023

Figure S2 shows representative flow gating strategies for the immunophenotyping of various sample types (tumor, healthy kidney, pre-REP TILs and REP TILs), as well as the co-culture assays.
Figure S13 from Immunological characterization and T-cell receptor repertoires of expanded tumor-infiltrating lymphocytes in renal cell carcinoma patients
Authors: Lee Moon Hee , Theodoropoulos Jason , Huuhtanen Jani , Bhattacharya Dipabarna , Järvinen Petrus , Tornberg Sara , Nísen Harry , Mirtti Tuomas , Uski Ilona , Kumari Anita , Peltonen Karita , Draghi Arianna , Donia Marco , Kreutzman Anna , Mustjoki Satu
Published: June 2023

Figure S13 shows analyses from the scRNA+TCRab-seq data, including the different UMAP clusters, differentially expressed genes and canonical marker gene expressions.
Detection of Modified Histones from Oral Mucosa of a Patient with DYT-KMT2B Dystonia
Authors: Sugeno Naoto , Hasegawa Takafumi , Haginoya Kazuhiro , Kubota Takafumi , Ikeda Kensuke , Nakamura Takaaki , Ishiyama Shun , Sato Kazuki , Yoshida Shun , Koshimizu Eriko , Uematsu Mitsugu , Miyatake Satoko , Matsumoto Naomichi , Aoki Masashi
Published: June 2023

Introduction: DYT-KMT2B is a rare childhood-onset, hereditary movement disorder typically characterized by lower-limb dystonia and subsequently spreads into the craniocervical and laryngeal muscles. Recently, KMT2B-encoding lysine (K)-specific histone methyltransferase 2B was identified as the causative gene for DYT-KMT2B, also known as DYT28. In addition to the fact that many physicians do not have sufficient experience or knowledge of hereditary dystonia, the clinical features of DYT-KMT2B overlap with those of other hereditary dystonia, and limited clinical biomarkers make the diagnosis difficult. Methods: Histone proteins were purified from the oral mucosa of patients with de novo KMT2B mutation causing premature stop codon, and then trimethylated fourth lysine residue of histone H3 (H3K4me3) which was catalyzed by KMT2B was analyzed by immunoblotting with specific antibody. We further analyzed the significance of H3K4me3 in patients with DYT-KMT2B using publicly available datasets. Results: H3K4me3 histone mark was markedly lower in the patient than in the control group. Additionally, a reanalysis of publicly available datasets concerning DNA methylation also demonstrated that KMT2B remained inactive in DYT-KMT2B. Discussion: Although only one case was studied due to the rarity of the disease, the reduction of H3K4me3 in the patient’s biological sample supports the dysfunction of KMT2B in DYT-KMT2B. Together with informatics approaches, our results suggest that KMT2B haploinsufficiency contributes to the DYT-KMT2B pathogenic process.
Delivering Personalized, Goal-Directed Care to Older Patients Receiving Peritoneal Dialysis
Authors: Wu Henry H.L. , Poulikakos Dimitrios , Hurst Helen , Lewis David , Chinnadurai Rajkumar
Published: June 2023

Background: An aging population living with chronic kidney disease and progressing to kidney failure, subsequently receiving peritoneal dialysis (PD) is growing. A significant proportion of these patients are also living with multi-morbidities and some degree of frailty. Recent practice recommendations from the International Society of Peritoneal Dialysis advocate for high-quality, goal-directed PD prescription, and the Standardized Outcomes of Nephrology-PD initiative emphasized the need for an individualized, goal-based care approach in all patients receiving PD treatment. In older patients, this approach to PD care is even more important. A frailty screening assessment, followed by a comprehensive geriatric assessment (CGA) prior to PD initiation and when dictated by change in relevant circumstances is paramount in tailoring PD care and prescription according to the needs, life goals, as well as clinical status of older patients with kidney failure. Summary: Our review aimed to summarize the different dimensions to be taken into account when delivering PD care to the older patient – from frailty screening and CGA in older patients receiving PD to employing a personalized, goal-directed PD prescription strategy, to preserving residual kidney function, optimizing blood pressure (BP) control, and managing anemia, to addressing symptom burden, to managing nutritional intake and promoting physical exercise, and to explore telehealth opportunities for the older PD population. Key Messages: What matters most to older PD patients may not be simply extending survival, but more importantly, to be living comfortably on PD treatment with minimal symptom burden in a home environment and to minimize treatment complications.
The Relationship between Metabolic Comorbidities and Post-Surgical Weight Loss Outcomes in Adolescents Undergoing Laparoscopic Sleeve Gastrectomy
Authors: Burghard Anne Claire , Rahming Virginia L. , Sonnett Fisher Anna , Zitsman Jeffrey L. , Oberfield Sharon E. , Fennoy Ilene
Published: June 2023

Introduction: Little is known about the relationship between metabolic factors and weight loss success in adolescents undergoing bariatric surgery. Methods: The objective of this study was to assess if baseline metabolic characteristics associate with weight loss in adolescents undergoing laparoscopic sleeve gastrectomy. A retrospective study was conducted in a comprehensive adolescent bariatric surgery center of 151 subjects (34 male, 117 female). Anthropometric measurements and metabolic factors including blood pressure, fasting glucose, hemoglobin A1c (HbA1c), metabolic syndrome (MeS), liver function, triglycerides, and waist circumference were collected at one pre-surgical visit and at 6- and/or 12-month post-laparoscopic sleeve gastrectomy. Weight loss was compared between subjects with normal or abnormal baseline metabolic factors. Absolute BMI change was used to measure successful weight loss. Results: Higher baseline systolic blood pressure (SBP) was associated with greater weight loss as measured by body mass index (BMI) change and BMI standard deviation score (BMI-SDS) change at 6 and 12 months. Those patients in the 6-month follow-up group with an abnormal HbA1c at baseline had significantly more weight loss as measured by BMI-SDS. None of the other parameters, including fasting glucose, MeS, liver function, triglycerides, and waist circumference showed a predictive relationship. Conclusion: Elevated SBP and HbA1c in adolescents with morbid obesity may reflect a population more likely to achieve successful weight loss and, thus, may be a good target for bariatric surgery, specifically laparoscopic sleeve gastrectomy, as an intervention for severe obesity. An assessment of behavioral differences in patients with and without elevated BP and HbA1c might explain the mechanism for the improved weight loss.
Internet of things time saving and management system for bus passengers
Authors: Alawad Ali Abdulaziz , Chughtai Muhammad Tajammal , Alanzi Majid Faleh
Published: June 2023

This article presents a novel type of mobile phone application approach using the wireless fidelity (WiFi) system. Which is capable of facilitating the public transport user and its drivers efficiently. The application support passengers when there are scenarios where commuters face problems while using public transport. If users get bus information beforehand, such as bus location and arrival time, the number of passengers in the public transportation system. This application has been developed for the Android operating system. The application includes bus details like real-time bus location, bus arrival time, bus routes, bus stops, bus numbers, and so on. After the trip is booked, users' devices allow real-time geolocation to be shared in the application, helping the bus driver decide to stop at one stop or move to another when there are no users.
Moth diversity of Guindy, Chennai, India and DNA barcoding of selected erebid moths
Authors: Bhuvaragavan Sreeramulu , Meenakumari Mani , Nivetha Ramanathan , Janarthanan Sundaram
Published: June 2023

In this study, diversity of moths has been documented from Chennai, the capital city of Tamil Nadu. During the study, over 100 specimens were collected from which 59 moth species were identified from the commercial hub of Chennai, Guindy. The species identified belonged to 52 genera, 11 families, and 25 subfamilies. Erebidae was a front runner, followed by Crambidae, Geometridae, Sphingidae, and Noctuidae. Furthermore, Eupterotidae, Uraniidae, Nolidae, Lasiocampidae, Pterophoridae, and Thyrididae were the least recorded families. Among 26 erebids, 14 species were subjected for identification through mitochondrial cytochrome oxidase subunit 1 gene to resolve the ambiguity. The sequences resulted were deposited in GenBank and BOLD system where they received accession numbers and process IDs. Further, phylogenetic analysis categorized Metanastria hyrtaca Cramer, 1782 in a separate clade.
On the occurrence of Nitella myriotricha A.Braun ex Kützing, 1857 ssp. acuminata D.Subramanian, 1999 (Charophyceae: Charales: Characeae), from eastern India
Authors: Mondal Kailash , Keshri Jai Prakash
Published: June 2023

Nitella myriotrichia A.Braun ex Kützing ssp. acuminata D.Subramanian 1999 has been recorded from different localities of West Bengal, eastern India. It is the first report of the taxon outside its original locality of occurrence at Kummidipoondi (Tamil Nadu) by Subramanian in 1999. The possibilities of endemism and origin of variations in this species have been discussed.
War prompts distress symptoms in Israeli Blind Snake
Authors: Dubiner Shahar , Meiri Shai , Levin Eran
Published: June 2023

During a series of explosions in a recent eruption of violence between Israel and Gaza, the metabolic rate of a Syrian Blind Snake Xerotyphlops syriacus peaked acutely, and its breathing pattern changed. This is the first record of a wild animal’s real-time physiological response to the noise of an incoming rocket attack and highlights the gap in our understanding of how anthropogenic noise – and military activity in general – affects individual wildlife.
Plastral deossification zones in the Endangered Spiny Hill Turtle Heosemys spinosa (Testudines: Geoemydidae) on Borneo
Authors: Baizurah Siti Nor , Das Indraneil
Published: June 2023

Studies of the evolution of turtle shell morphology have raised numerous questions. In this study, five adult females and two adult males of the Endangered Spiny Hill Turtle Heosemys spinosa from two localities in western Sarawak in East Malaysia (Borneo) were examined for the presence of plastral deossification zones, reported as indicative of kinesis in earlier studies. A total of 52 (34 females, 18 males) radiographs demonstrated distinct poorly-ossified areas across the hyo-hypoplastral and the hypo-xiphiplastral junctures in females of straight carapace length (SCL) 143.4–211.4 mm. The feature is here interpreted as a permanent plastral hinge, which was not observed in either of the males examined. The smallest female with a weak but discernible line at the contact of these bones had a SCL of 125 mm, suggestive of minimum size of maturity in Heosemys spinosa in this population.
New state records of some Dermaptera De Geer, 1773 (Insecta) species in India
Authors: Das Tanusri , Kochumackel George Emiliyamma  , Sarkar Subhankar Kumar
Published: June 2023

The insect order Dermaptera is globally composed of approximately 2,000 species distributed over 245 genera and 16 families, of which approximately 285 species composed within 72 genera and 16 families are known from India until now. A recent examination of some unidentified Dermaptera species housed in the National Zoological Collection of the Zoological Survey of India revealed new state records for six Dermaptera species in India. All the six species are dealt herein with material examined, diagnostic characters, distribution, remarks, and photographs of adult male and female, penultimate sternite and ultimate tergite with forceps, and male genitalia.
Optimal design and control of hybrid synchronous generator regulating turbine angular speed for turbine protection
Authors: Tounsi Souhir
Published: June 2023

In this paper is presented a methodology of systemic design and control of a synchronous generator with hybrid excitation for the generation of wind energy. The design of the generator is made by the analytical method taking into account the interactions of the global system. Indeed, the regulation of the speed of the turbine is ensured by adjustment of the excitation current to regulate the electromagnetic torque and in this case the excitation current is limited to a fixed value since the increase of excitation current leads to an increase generator’s phase currents magnitude. The increase of the phase’s currents of the generator is linked to the increase of the amplitude of the electromotive forces depending on the excitation current. Therefore, to limit the amplitude of the phase’s currents to the value of the design current fixed by the note book specifications for a given power of the wind turbine, it is necessary to limit the excitation current by limiting the supply voltage of the DC-DC converter used to vary the excitation current for the regulation of the electromagnetic torque.

This technique of speed adjustment is simpler and less expensive than techniques using mechanical and hydraulic braking systems.
Application of cell laden hydrogels with temporally tunable stiffness in biomedical research
Authors: AhmadianKia Naghmeh , Goli-Malekabadi Zahra , Pournaghmeh Shayan
Published: June 2023

Extracellular matrix (ECM) is a dynamic and complex environment regulating the cell fate and behavior. It is characterized by biophysical and biochemical properties specific for each tissue. Interestingly, hydrogels can serve as exceptional artificial cellular microenvironments as they can be designed to mimic the key features of the native ECM. They are valuable tools to understand how cells respond to complex microenvironments in normal and pathologic conditions. However, unlike the highly dynamic structure of ECM, nearly all of the conventional hydrogel platforms are primarily static and lack the dynamic properties of native extracellular matrices. Thus, it is necessary to develop dynamic hydrogels to better understand the mechanisms by which dynamic changes of ECM contribute to biological processes. Stiffness is one of the significant dynamic components of ECM which must be appropriately mimicked over time in vitro. In this review, we cover recent advances in engineering strategies to make cell laden hydrogels with temporally tunable stiffness. We also highlight the applications of these hydrogel systems in biomedicine focusing on specific examples in cancer, cardiovascular system, tissue fibrosis and stem cell research. Finally, the challenges regarding the development and application of cell laden hydrogels with temporally tunable stiffness are proposed.
Multi-axis and cornering stiffness properties of non-pneumatic wheels with symmetric helical honeycomb spokes
Authors: Zheng Zhou , Dorugade Darshan , Rakheja Subhash , Sedaghati Ramin
Published: June 2023

Current non-pneumatic wheel (NPW) designs with non-helical honeycomb spokes generally show too high cornering stiffness and thereby rapid saturation of the cornering force, which may lead to inferior handling and directional control of the vehicle, particularly under high operating speeds. The design concept of NPWs with symmetric helical honeycomb spokes is thus proposed in this paper. Three-dimensional (3D) finite element (FE) models of a honeycomb NPW with symmetric helical spokes configurations of different cell and helix angles were developed in order to fundamentally study its multi-axis and cornering stiffness properties under a constant normal load. The validities of the developed NPW models with 0° helix angle and three different cell angles were demonstrated through comparisons of predicted wheel responses with results available in published studies. 3D simulations were conducted under two design constraints in terms of identical cell-wall thickness and identical load carrying capacity. The results suggest that increasing helix angle results in significantly greater in-plane shear stiffness of the honeycomb spokes and thus could effectively yield higher longitudinal and vertical stiffness of the NPW. An increase in helix angle also causes lower lateral stiffness for the wheel designs with 15.8° and 31.5° cell angles resulting from increases in the out-of-plane compliance of the spokes, apart from the notably lower cornering stiffness, particularly when it is increased to 30° and 45°. The cell-wall thickness, however, shows positive influences on multi-axis stiffness of the honeycomb wheel but negative effects on its cornering stiffness. The design concept of helical honeycomb spokes could offer better vehicle performances than the current designs in terms of braking/traction and handling characteristics. These are particularly important for promoting applications of the NPW in high-speed vehicles.
The Efficacy of Volumetric Modulated Arc Therapy Combined With Chemotherapy, Brachytherapy, and Local Hyperthermia on Patients with Locally Advanced Cervical Cancer: A Retrospective Study
Authors: Jiang Ping , Wei Shuhua , Bai Yan , Qu Ang , Jiang Weijuan , Sun Haitao , Wang Junjie
Published: June 2023

Objective

To evaluate the clinical outcomes of volumetric modulated arc therapy (VMAT) followed by brachytherapy (BT), combined with chemotherapy, and local hyperthermia (HT) on locally advanced cervical cancer (LACC).

Methods

In total, 40 patients with FIGO stage IB1-IVB cervical cancer from January 2016 to December 2018 were selectively enrolled in this study. All patients were treated with VMAT (50.4 Gy/1.8 Gy/28 f) concurrent with cisplatin-based chemotherapy (40 mg/m2, q1w, 6 cycles) and local HT (40.5-41°C for 60 min, BIW). BT (30-36 y/5-6 f, 2 f/w) was conducted after VMAT. Objective response rate (ORR), local control (LC) time, LC rate, progression-free survival (PFS) rate, cancer-specific survival (CSS) rate, overall survival (OS), median time to tumor progression and treatment-related toxicity were evaluated.

Results

The median follow-up time was 31 months (8-48). The ORR was 100% at 3 months after treatment and 92.1% at 6 months, respectively. The 1-year, 2-year, and 3-year LC rates were 87.4%, 81.9%, and 70.9%, respectively. The average LC time was 31.50 ± 1.89 months (95% CI 27.79-35.21). The 1-year, 2-year, and 3-year PFS rates were 75.85%, 61.2%, and 51.3%, respectively, while the median PFS was 27.07 months. The 1-year, 2-year, and 3-year OS rates were 95%, 84%, and 79.6%, respectively. In total, 12(30%) patients had grade 3/4 bone marrow suppression. One patient had grade 4 leukopenia. In total, 17 patients had grade 1/2 bone marrow suppression. Two patients had grade 3 nausea and grade 3 vomiting reaction, respectively. No grade 3/4 proctitis and bladder reaction were observed. In the late period of treatment, 1 patient had a rectal hemorrhage. In total, 13 patients had vaginal stenosis.

Conclusion

VMAT concurrent with chemotherapy, BT, and local HT had a favorable short-term efficacy and acceptable toxicity on cervical cancer, which was an alternative option for LACC.
Players Just Want to Have Fun? An Exploratory Survey on Hedonic and Eudaimonic Game Motives
Authors: Possler Daniel , Daneels Rowan , Bowman Nicholas D.
Published: June 2023

Research has shown that seeking fun and enjoyment (i.e., hedonic reasons) motivates playing digital games. However, recent scholarship revealed that gaming also evokes eudaimonic entertainment experiences, such as meaningfulness and being moved. Yet, it is unclear whether players turn to games to have such eudaimonic experiences. Hence, the present study explored potential eudaimonic gaming motives in an online survey among fans ( N = 894) of five yet-to-be-released games. Specifically, it was examined whether eudaimonic motives, derived from gaming research and scholarship in positive psychology, complement an existing scale measuring gaming motives. Exploratory and confirmatory factor analysis (split-half method) demonstrated that “Eudaimonia” represents a distinct reason to play—alongside the well-known motives of “Absorption” and “Social Interaction.” Moreover, the Eudaimonia motive for using the five games was positively related to general eudaimonic orientations in life and trait-like eudaimonic game preferences. The results suggest that digital gaming may also be eudaimonically motivated.
Managing Fear During Pandemics: Risks and Opportunities
Authors: Mertens Gaëtan , Engelhard Iris M. , Novacek Derek M. , McNally Richard J.
Published: June 2023

Fear is an emotion triggered by the perception of danger and motivates safety behaviors. Within the context of the COVID-19 pandemic, there were ample danger cues (e.g., images of patients on ventilators) and a high need for people to use appropriate safety behaviors (e.g., social distancing). Given this central role of fear within the context of a pandemic, it is important to review some of the emerging findings and lessons learned during the COVID-19 pandemic and their implications for managing fear. We highlight factors that determine fear (i.e., proximity, predictability, and controllability) and review several adaptive and maladaptive consequences of fear of COVID-19 (e.g., following governmental health policies and panic buying). Finally, we provide directions for future research and make policy recommendations that can promote adequate health behaviors and limit the negative consequences of fear during pandemics.
Tourists’ Compliance With Public Policy and Government Trust: An Application of Protection Motivation Theory
Authors: Subedi Swechchha , Kubickova Marketa
Published: June 2023

Based on the Protection Motivation Theory (PMT), this study investigates the impact of risk perception (threat appraisal and coping appraisal) and trust in the destination government on tourists’ self-protective behavior. Survey data from 450 international tourists from the United States were collected through mTurk and analyzed using structural equation modeling (SEM) with SmartPLS 3.0. The results suggest that tourists’ self-protective behavior is directly influenced by their perception of threats and the appraisal of coping mechanisms, but not by trust in the destination government. However, trust in the destination government has an indirect effect on self-protective behavior mediated by threat appraisal and coping appraisal. Thus, tourism stakeholders must focus on building and maintaining trust in government to encourage compliance and self-protective behavior of tourists. Limitations, implications, and suggestions for future research are further discussed.
Using the TIDieR checklist to describe development and integration of a web-based intervention promoting healthy eating and regular exercise among older cancer survivors
Authors: Rogers Laura Q. , Pekmezi Dori , Schoenberger-Godwin Yu-Mei , Fontaine Kevin R. , Ivankova Nataliya V. , Kinsey Amber W. , Hoenemeyer Teri , Martin Michelle Y. , Pisu Maria , Farrell David , Wall Jonathan , Waugaman Kaitlyn , Oster Robert A. , Kenzik Kelly , Winters-Stone Kerri , Demark-Wahnefried Wendy
Published: June 2023

Objective

To facilitate replication and future intervention design of web-based multibehavior lifestyle interventions, we describe the rationale, development, and content of the Ai M, Plan, and act on LIFest Yles (AMPLIFY) Survivor Health intervention which provides healthy eating and exercise behavior change support for older cancer survivors. The intervention promotes weight loss, improvements in diet quality, and meeting exercise recommendations.

Methods

The Template for Intervention Description and Replication (TIDieR) checklist was used to provide a comprehensive description of the AMPLIFY intervention, consistent with CONSORT recommendations.

Results

A social cognitive theory web-based intervention founded on the core components of efficacious print and in-person interventions was conceptualized and developed through an iterative collaboration involving cancer survivors, web design experts, and a multidisciplinary investigative team. The intervention includes the AMPLIFY website, text and/or email messaging, and a private Facebook group. The website consists of: (1) Sessions (weekly interactive e-learning tutorials); (2) My Progress (logging current behavior, receiving feedback, setting goals); (3) Tools (additional information and resources); (4) Support (social support resources, frequently asked questions); and (5) Home page. Algorithms were used to generate fresh content daily and weekly, tailor information, and personalize goal recommendations. An a priori rubric was used to facilitate intervention delivery as healthy eating only (24 weeks), exercise only (24 weeks), or both behaviors concurrently over 48 weeks.

Conclusions

Our TIDieR-guided AMPLIFY description provides pragmatic information helpful for researchers designing multibehavior web-based interventions and enhances potential opportunities to improve such interventions.
Atomic simulation of crystal orientation and workpiece composition effect on nano-scratching of SiGe alloy
Authors: Liu Changlin , To Suet , Sheng Xuexiang , Wang Ruoxin , Xu Jianfeng
Published: June 2023

Silicon–germanium (SiGe) alloy is a new semiconductor material of great interest in thermoelectric devices, optoelectronic devices, infrared detectors, and semiconductor industry. In the present work, molecular dynamics simulation was conducted to investigate the deformation behavior in nano-scratching of SiGe alloy. The effect of scratching direction and Ge composition on material removal mechanism was discussed, aiming to understand the nanoscale deformation mechanism of SiGe alloy. The simulation results indicate that the machining direction and Ge composition have significant influences on the atomic flow and chip formation during nano-scratching. Besides, less subsurface damage and elastic recovery are observed when scratching along the (011)[100] direction with higher Ge composition. The highest crystal purity of the machined surface is achieved when scratching on the Si60Ge40 workpiece. Furthermore, the Ge composition has a significant influence on the workpiece temperature due to the variation of the thermal conductivity of the workpiece. This work could enrich the understanding of the deformation mechanism of SiGe alloy during nanoscale machining and open a potential to improve the machining performance of multicomponent semiconductor materials.