bluuebunny/crossref_metadata_2025 huggingface dataset:
Instantaneous Networking Service Availability for Disaster Recovery
Authors: Teng Rui , Sakano Toshikazu , Suzuki Yoshinori
Published: December 2020

Networking services may be broken down in a disaster situation while people in the disaster area(s) strongly demand networking services for both communication and information sharing among users. This requires the fast restoration of networking services to fulfil the demand–supply gap. Although there are a number of studies on restoring communication and networking in disasters, few studies have explicitly examined the service availability during the temporary and partial recovery process of network restoration. From the perspective of users in the disaster area, it is important to be able to communicate or share information with people whenever they want/need to do so. Therefore, partial and local recovery of the networking services also plays an important role for improving service availability in the disaster situations. To assess the restoration effectiveness of networking services with a measure of user satisfaction level, we propose to use instant networking service availability (I-NSA), a novel metric, and we examine the effectiveness of networking service restoration solutions using the metric. I-NSA allows us to clearly express the instant availability of networking services that drastically changes with the elapsed time from the disaster occurrence in disaster areas. This paper examines the effective improvement of I-NSA when Local-and-Instant Clouds (LI-Clouds) are applied to the disaster situation. LI-Cloud has been designed and practically developed to provide deployable networking services to users. We verify that LI-Cloud enables significant improvement on the I-NSA performance in the fast restoration of networking services.
Development of Post Processing for Wave Propagation Problem: Response Filtering Method
Authors: Koh Hyeong Seok , Lee Jong Wook , Kwon Kiwoon , Yoon Gil Ho
Published: December 2020

This study develops a new response filtering approach for recovering dynamic mechanical stresses under impact loading. For structural safety, it is important to consider the propagation of transient mechanical stresses inside structures under impact loads. Commonly, mechanical stress waves can be obtained by solving Newton’s second law using explicit or implicit finite element procedures. Regardless of the numerical approach, large discrepancies called the Gibb’s phenomenon are observed between the numerical solution and the analytical solution. To reduce these discrepancies and enhance the accuracy of the numerical solution, this study develops a response filtering method (RFM). The RFM averages the transient responses within split time domains. By solving several benchmark problems and analyzing the stresses in the frequency domain, it was possible to verify that the RFM can provide an improved solution that converges toward the analytical solution. A mathematical theory is also presented to correlate the relationship between the filtering length and the frequency components of the filtered stress values.
Dynamics Test Research of Bounce of Carrier-Based Aircraft Arresting Hook
Authors: Peng Yiming , Xie Pengpeng , Wei Xiaohui , Nie Hong
Published: December 2020

The test of arresting hook bounce is one of the most essential technologies in the design and research of arresting hook. In order to research the dynamic performance of the hook after touchdown and impacting with the deck when the aircraft is arrested, an approach for a certain type of aircraft arresting hook bounce test is proposed in this paper. Solutions to critical technique issues arising in the test process such as aircraft sinking velocity control, aircraft horizontal velocity simulation, and simulation of the performance of the damper are derived and verified by the bounce test of the arresting hook. The bounce height, bounce distance, stroke length of the arresting hook damper after the hook is impacted are measured by the test. The test method proposed can be used for researching the bounce of arresting hook and providing reliable test data for the design of carrier-based aircraft and arresting hook.
Enhancement of Power System Transient Stability by the Coordinated Control between an Adjustable Speed Pumping Generator and Battery
Authors: Tamura Junji , Umemura Atsushi , Takahashi Rion , Sakahara Atsushi , Tosaka Fumihito , Nakamoto Ryosuke
Published: December 2020

The penetration level of large-scale wind farms into power systems has been increasing significantly, and the frequency stability and transient stability of the power systems during and after a network fault can be negatively affected. This paper proposes a new control method to improve the stability of power systems that are composed of large wind farms, as well as usual synchronous generators. The new method is a coordinated controlling method between an adjustable-speed pumping generator (ASG) and a battery. The coordinated system is designed to improve power system stability during a disconnection in a fixed-rotor-speed wind turbine with a squirrel cage-type induction generator (FSWT-SCIG)-based wind farm due to a network fault, in which a battery first responds quickly to the system frequency deviation due to a grid fault and improves the frequency nadir, and then the ASG starts to supply compensatory power to recover the grid frequency to the rated frequency. The performance of the proposed system was confirmed through simulation studies on a power system model consisting of usual synchronous generators (SGs), an ASG, a battery, and an SCIG-based wind farm. Simulation results demonstrated that the proposed control system can enhance the stability of the power system effectively.
The Potential of a Tailored Biomimetic Hydrogel for In Vitro Cell Culture Applications: Characterization and Biocompatibility
Authors: Cho Yung-Chieh , Huang Hsiao-Ting , Lan Wen-Chien , Huang Mao-Suan , Saito Takashi , Huang Bai-Hung , Tsai Chi-Hsun , Fan Fang-Yu , Ou Keng-Liang
Published: December 2020

In this study, the Pluronic F127 with modified tripeptide Gly-Arg-Gly-Asp copolymer (hereafter defined as 3BE) hydrogel was evaluated in terms of its biocompatibility potentials. The fibroblasts (Swiss 3T3 cell line) and human hair follicles-derived mesenchymal stem cells (HFMSCs) were cultured in different concentrations of the 3BE hydrogel (0%, 0.05%, 0.1%, 0.25%, and 0.5%, respectively). The cell morphology and differentiation potential of HFMSCs were observed through optical microscopy, and the cell viability was investigated via Live/Dead Kit and Cell Counting Kit-8 assay. Analytical results showed that HFMSC can differentiate into adipogenic, chondrogenic, and osteogenic lineages. The HFMSC and Swiss 3T3 cells would properly assemble into a spherical shape as cultured with the 3BE hydrogel. Most importantly, cell viability could be maintained above 70%. The formation of spheroid structures of cells within this hydrogel is predicted to promote cell differentiation potentials of HFMSC that benefit in generating functional adipocytes, chondrocytes, and osteoblasts. Therefore, these findings demonstrate that the 3BE hydrogel has great potential as a three-dimensional cell culture scaffold for tissue engineering applications.
Dynamic Topology Model of Q-Learning LEACH Using Disposable Sensors in Autonomous Things Environment
Authors: Cho Jae Hyuk , Lee Hayoun
Published: December 2020

Low-Energy Adaptive Clustering Hierarchy (LEACH) is a typical routing protocol that effectively reduces transmission energy consumption by forming a hierarchical structure between nodes. LEACH on Wireless Sensor Network (WSN) has been widely studied in the recent decade as one key technique for the Internet of Things (IoT). The main aims of the autonomous things, and one of advanced of IoT, is that it creates a flexible environment that enables movement and communication between objects anytime, anywhere, by saving computing power and utilizing efficient wireless communication capability. However, the existing LEACH method is only based on the model with a static topology, but a case for a disposable sensor is included in an autonomous thing’s environment. With the increase of interest in disposable sensors which constantly change their locations during the operation, dynamic topology changes should be considered in LEACH. This study suggests the probing model for randomly moving nodes, implementing a change in the position of a node depending on the environment, such as strong winds. In addition, as a method to quickly adapt to the change in node location and construct a new topology, we propose Q-learning LEACH based on Q-table reinforcement learning and Fuzzy-LEACH based on Fuzzifier method. Then, we compared the results of the dynamic and static topology model with existing LEACH on the aspects of energy loss, number of alive nodes, and throughput. By comparison, all types of LEACH showed sensitivity results on the dynamic location of each node, while Q-LEACH shows best performance of all.
Aveiro Canyon Head (Portugal) Submarine Slope Instability Assessment
Authors: Lapa Nuno , Marques Fernando M. F. S. , Rodrigues Aurora
Published: December 2020

Mass wasting events are the main processes of sedimentary dynamics that affect the marine environment and which, due to their spatial and temporal variability, are difficult to study and evaluate. Affecting the marine floor, between the coastline and the abyssal plain, these processes are triggered by multiple causes, having different magnitudes and causing drastic changes and impacts on the marine environment and human activities. In this paper, the submarine landslide susceptibility affecting the upper course of the Aveiro canyon (West Iberian Margin) is addressed using statistical models which are based on the statistical relations between a landslide inventory and the landslide predisposing factors bathymetry, sediment cover, slope angle, aspect and curvature. The statistical methods were the widely proven bivariate information value (IV) and the multivariate logistic regression (LR). The model results were validated against the landslide inventory using receiver operating characteristic (ROC) curves and the corresponding area under the curve (AUC), which provided satisfactory results, with IV AUC = 0.79 and LR AUC = 0.83, in spite of the limitations of the databases used in this study. The results obtained suggest that these methods may be useful for the preliminary assessment of sea floor slope instability at a regional scale of analysis, enabling the selection of sites to be studied with much more detailed and expensive methods.
In Vitro Comparison of Bioactive Silicon Nitride Laser Claddings on Different Substrates
Authors: Marin Elia , Zanocco Matteo , Boschetto Francesco , Yamamoto Toshiro , Kanamura Narisato , Zhu Wenliang , McEntire Bryan J. , Bal Bhajanjit Sonny , Ashida Ryutaro , Mazda Osam , Pezzotti Giuseppe
Published: December 2020

The performance, durability, and bio-integration of functional biomedical coatings can be enhanced by changing or improving their substrate properties. In this study, we applied silicon nitride powder-based laser claddings to various substrates and undertook an in vitro assessment of their osteoconductive and antibacterial properties. The substrates included common arthroplasty materials: polyethylene, titanium, zirconia-toughened alumina, and zirconia. Multiple analytical techniques were used to characterize the physical and chemical structure of the claddings after deposition. Partial decomposition of the silicon nitride powders occurred during the cladding process, resulting in nitrogen loss during intermetallic formation phases under some substrate and treatment conditions. The osteoconductive capabilities of various laser-cladded substrates were evaluated in a SaOS-2 osteosarcoma cell culture by measuring the amount of bone formation on the coated surface. Antibacterial testing was performed using Gram-positive Staphylococcus epidermidis at 24 and 48 h of incubation. Silicon nitride coating enhanced both osteoconductive and antibacterial properties.
Model of Complex Heat Transfer in the Package of Rectangular Steel Sections
Authors: Wyczółkowski Rafał , Gała Marek , Bagdasaryan Vazgen
Published: December 2020

During heat treatment of rectangular steel sections, a heated charge in the form of regularly arranged packages is placed in a furnace. The article presents a model of a complex heat transfer in such a package using the thermo-electric analogy. The model considers the following types of heat transfer: conduction in section walls, conduction and natural convection within gas, heat radiation between the walls of a section, as well as contact conduction between the adjacent sections. The results of our own experimental research were used for calculations of heat resistance applying to natural convection and contact conduction. We assumed that the material of sections was low-carbon steel and the gas was air. The result of the calculations of the presented model is total thermal resistance Rto. The calculations were performed for the temperature range 20–700 °C for four geometrical cases. Due to the variability of conditions for contact heat conduction, we assumed that total thermal resistance for a given charge is contained within a value range between Rto-min and Rto-max. We established that the value of Rto depends significantly on the section’s geometry. The larger the section sizes, the greater the changes of Rto. The minimal and maximal values of Rto for all packages were 0.0051 (m2·K)/W and 0.0238 (m2·K)/W, respectively. The correctness of model calculations was verified with the use of experimental data.
Pollution Caused by Potentially Toxic Elements Present in Road Dust from Industrial Areas in Korea
Authors: Jeong Hyeryeong , Choi Jin Young , Lim Jaesoo , Ra Kongtae
Published: December 2020

We examined the pollution characteristics of potentially toxic elements (PTEs) in road dust (RD) from nine industrial areas in South Korea to assess PTE pollution levels and their environmental risks for devising better strategies for managing RD. The median concentrations (mg/kg) were in the order Zn (1407) > Cr (380) > Cu (276) > Pb (260) > Ni (112) > As (15) > Cd (2) > Hg (0.1). The concentration of PTEs was the highest at the Onsan Industrial Complex, where many smelting facilities are located. Our results show that Onsan, Noksan, Changwon, Ulsan, Pohang, and Shihwa industrial areas are heavily polluted with Cu, Zn, Cd, and Pb. The presence of these toxic elements in RD from the impervious layer in industrial areas may have a moderate to severe effect on the health of the biota present in these areas. The potential ecological risk index (Eri) for PTEs was in the decreasing order of Cd > Pb > Hg > Cu > As > Zn > Ni > Cr, indicating that the dominant PTE causing ecological hazards is Cd owing to its high toxicity. Our research suggests the necessity for the urgent introduction of an efficient management strategy to reduce RD, which adds to coastal pollution and affects human health.
Rainfall Threshold for Shallow Landslides Initiation and Analysis of Long-Term Rainfall Trends in a Mediterranean Area
Authors: Roccati Anna , Paliaga Guido , Luino Fabio , Faccini Francesco , Turconi Laura
Published: December 2020

The effects of climate change on landslide activity may have important environmental, socio-economic, and political consequences. In the last decades, several short-term extreme rainfall events affected Mediterranean regions, resulted in damaging geo-hydrological processes and casualties. It is unequivocal that the impact of landslides in several Mediterranean countries is increasing with time, but until now, there has been little or no quantitative data to support these increases. In this paper, both rainfall conditions for the occurrence of shallow landslides and rainfall trends were investigated in the Portofino promontory, which extends in the Ligurian Sea, where heavy rainfall and related ground effects often occur. Adopting a frequentist approach, the empirical intensity-duration threshold was estimated. Our findings highlight that the rainfall intensity required to trigger landslides is lower for the same duration than those expected in other similar environments, suggesting a high susceptibility to rainfall-induced landslides in the Portofino territory. Further, the Mann-Kendall test and Hurst exponent were used for detecting potential trends. Analysis of long-term rainfall time series showed statistically significant increasing trends in short duration precipitation occurrence and rainfall rates, suggesting a possible future scenario with a more frequent exceedance of the threshold triggering value and an increase of landslide risk.
Carbonaceous Aerosols in PM1, PM2.5, and PM10 Size Fractions over the Lanzhou City, Northwest China
Authors: Zhang Xin , Li Zhongqin , Wang Feiteng , Song Mengyuan , Zhou Xi , Ming Jing
Published: December 2020

Carbonaceous particles have been confirmed as major components of ambient aerosols in urban environments and are related to climate impacts and environmental and health effects. In this study, we collected different-size particulate matter (PM) samples (PM1, PM2.5, and PM10) at an urban site in Lanzhou, northwest China, during three discontinuous one-month periods (January, April, and July) of 2019. We measured the concentrations and potential transport pathways of carbonaceous aerosols in PM1, PM2.5, and PM10 size fractions. The average concentrations of OC (organic carbon) and EC (elemental carbon) in PM1, PM2.5, and PM10 were 6.98 ± 3.71 and 2.11 ± 1.34 μg/m3, 8.6 ± 5.09 and 2.55 ± 1.44 μg/m3, and 11.6 ± 5.72 and 4.01 ± 1.72 μg/m3. The OC and EC concentrations in PM1, PM2.5, and PM10 had similar seasonal trends, with higher values in winter due to the favorable meteorology for accumulating pollutants and urban-increased emissions from heating. Precipitation played a key role in scavenge pollutants, resulting in lower OC and EC concentrations in summer. The OC/EC ratios and principal component analysis (PCA) showed that the dominant pollution sources of carbon components in the PMs in Lanzhou were biomass burning, coal combustion, and diesel and gasoline vehicle emissions; and the backward trajectory and concentration weight trajectory (CWT) analysis further suggested that the primary pollution source of EC in Lanzhou was local fossil fuel combustion.
The Use of Gaussian Mixture Models with Atmospheric Lagrangian Particle Dispersion Models for Density Estimation and Feature Identification
Authors: Crawford Alice
Published: December 2020

Atmospheric Lagrangian particle dispersion models, LPDM, simulate the dispersion of passive tracers in the atmosphere. At the most basic level, model output consists of the position of computational particles and the amount of mass they represent. In order to obtain concentration values, this information is then converted to a mass distribution via density estimation. To date, density estimation is performed with a nonparametric method so that output consists of gridded concentration data. Here we introduce the use of Gaussian mixture models, GMM, for density estimation. We compare to the histogram or bin counting method for a tracer experiment and simulation of a large volcanic ash cloud. We also demonstrate the use of the mixture model for automatic identification of features in a complex plume such as is produced by a large volcanic eruption. We conclude that use of a mixture model for density estimation and feature identification has potential to be very useful.
The Transient Mechanics of Muscle Require Only a Single Force-Producing Cross-Bridge State and a 100 Å Working Stroke
Authors: Knupp Carlo , Squire John M.
Published: December 2020

An informative probe of myosin cross-bridge behaviour in active muscle is a mechanical transient experiment where, for example, a fully active muscle initially held at constant length is suddenly shortened to a new fixed length, providing a force transient, or has its load suddenly reduced, providing a length transient. We describe the simplest cross-bridge mechanical cycle we could find to model these transients. We show using the statistical mechanics of 50,000 cross-bridges that a simple cycle with two actin-attached cross-bridge states, one producing no force and the other producing force, will explain much of what has been observed experimentally, and we discuss the implications of this modelling for our understanding of how muscle works. We show that this same simple model will explain, reasonably well, the isotonic mechanical and X-ray transients under different loads observed by Reconditi et al. (2004, Nature 428, 578) and that there is no need to invoke different cross-bridge step sizes under these different conditions; a step size of 100 Å works well for all loads. We do not claim that this model provides a total mechanical explanation of how muscle works. However, we do suggest that only if there are other observations that cannot be explained by this simple model should something more complicated be considered.
On the Liquid Chemistry of the Reactive Nitrogen Species Peroxynitrite and Nitrogen Dioxide Generated by Physical Plasmas
Authors: Bruno Giuliana , Wenske Sebastian , Lackmann Jan-Wilm , Lalk Michael , von Woedtke Thomas , Wende Kristian
Published: December 2020

Cold physical plasmas modulate cellular redox signaling processes, leading to the evolution of a number of clinical applications in recent years. They are a source of small reactive species, including reactive nitrogen species (RNS). Wound healing is a major application and, as its physiology involves RNS signaling, a correlation between clinical effectiveness and the activity of plasma-derived RNS seems evident. To investigate the type and reactivity of plasma-derived RNS in aqueous systems, a model with tyrosine as a tracer was utilized. By high-resolution mass spectrometry, 26 different tyrosine derivatives including the physiologic nitrotyrosine were identified. The product pattern was distinctive in terms of plasma parameters, especially gas phase composition. By scavenger experiments and isotopic labelling, gaseous nitric dioxide radicals and liquid phase peroxynitrite ions were determined as dominant RNS. The presence of water molecules in the active plasma favored the generation of peroxynitrite. A pilot study, identifying RNS driven post-translational modifications of proteins in healing human wounds after the treatment with cold plasma (kINPen), demonstrated the presence of in vitro determined chemical pathways. The plasma-driven nitration and nitrosylation of tyrosine allows the conclusion that covalent modification of biomolecules by RNS contributes to the clinically observed impact of cold plasmas.
High-Density Lipoprotein-Targeted Therapies for Heart Failure
Authors: Mishra Mudit , De Geest Bart
Published: December 2020

The main and common constituents of high-density lipoproteins (HDLs) are apolipoprotein A-I, cholesterol, and phospholipids. Biochemical heterogeneity of HDL particles is based on the variable presence of one or more representatives of at least 180 proteins, 200 lipid species, and 20 micro RNAs. HDLs are circulating multimolecular platforms that perform divergent functions whereby the potential of HDL-targeted interventions for treatment of heart failure can be postulated based on its pleiotropic effects. Several murine studies have shown that HDLs exert effects on the myocardium, which are completely independent of any impact on coronary arteries. Overall, HDL-targeted therapies exert a direct positive lusitropic effect on the myocardium, inhibit the development of cardiac hypertrophy, suppress interstitial and perivascular myocardial fibrosis, increase capillary density in the myocardium, and prevent the occurrence of heart failure. In four distinct murine models, HDL-targeted interventions were shown to be a successful treatment for both pre-existing heart failure with reduced ejection fraction (HFrEF) and pre-existing heart failure with preserved ejection fraction (HFrEF). Until now, the effect of HDL-targeted interventions has not been evaluated in randomized clinical trials in heart failure patients. As HFpEF represents an important unmet therapeutic need, this is likely the preferred therapeutic domain for clinical translation.
The Role of Corticotropin-Releasing Hormone at Peripheral Nociceptors: Implications for Pain Modulation
Authors: Zheng Haiyan , Lim Ji Yeon , Seong Jae Young , Hwang Sun Wook
Published: December 2020

Peripheral nociceptors and their synaptic partners utilize neuropeptides for signal transmission. Such communication tunes the excitatory and inhibitory function of nociceptor-based circuits, eventually contributing to pain modulation. Corticotropin-releasing hormone (CRH) is the initiator hormone for the conventional hypothalamic-pituitary-adrenal axis, preparing our body for stress insults. Although knowledge of the expression and functional profiles of CRH and its receptors and the outcomes of their interactions has been actively accumulating for many brain regions, those for nociceptors are still under gradual investigation. Currently, based on the evidence of their expressions in nociceptors and their neighboring components, several hypotheses for possible pain modulations are emerging. Here we overview the historical attention to CRH and its receptors on the peripheral nociception and the recent increases in information regarding their roles in tuning pain signals. We also briefly contemplate the possibility that the stress-response paradigm can be locally intrapolated into intercellular communication that is driven by nociceptor neurons. Such endeavors may contribute to a more precise view of local peptidergic mechanisms of peripheral pain modulation.
Effects of Juvenile or Adolescent Working Memory Experience and Inter-Alpha Inhibitor Protein Treatment after Neonatal Hypoxia-Ischemia
Authors: Bradford Aaron , Hernandez Miranda , Kearney Elaine , Theriault Luke , Lim Yow-Pin , Stonestreet Barbara S. , Threlkeld Steven W.
Published: December 2020

Hypoxic-Ischemic (HI) brain injury in the neonate contributes to life-long cognitive impairment. Early diagnosis and therapeutic interventions are critical but limited. We previously reported in a rat model of HI two interventional approaches that improve cognitive and sensory function: administration of Inter-alpha Inhibitor Proteins (IAIPs) and early experience in an eight-arm radial water maze (RWM) task. Here, we expanded these studies to examine the combined effects of IAIPs and multiple weeks of RWM assessment beginning with juvenile or adolescent rats to evaluate optimal age windows for behavioral interventions. Subjects were divided into treatment groups; HI with vehicle, sham surgery with vehicle, and HI with IAIPs, and received either juvenile (P31 initiation) or adolescent (P52 initiation) RWM testing, followed by adult retesting. Error rates on the RWM decreased across weeks for all conditions. Whereas, HI injury impaired global performance as compared to shams. IAIP-treated HI subjects tested as juveniles made fewer errors as compared to their untreated HI counterparts. The juvenile group made significantly fewer errors on moderate demand trials and showed improved retention as compared to the adolescent group during the first week of adult retesting. Together, results support and extend our previous findings that combining behavioral and anti-inflammatory interventions in the presence of HI improves subsequent learning performance. Results further indicate sensitive periods for behavioral interventions to improve cognitive outcomes. Specifically, early life cognitive experience can improve long-term learning performance even in the presence of HI injury. Results from this study provide insight into typical brain development and the impact of developmentally targeted therapeutics and task-specific experience on subsequent cognitive processing.
Features of Action Potentials from Identified Thalamic Nuclei in Anesthetized Patients
Authors: Pastor Jesús , Vega-Zelaya Lorena
Published: December 2020

Our objective was to describe the electrophysiological properties of the extracellular action potential (AP) picked up through microelectrode recordings (MERs). Five patients were operated under general anesthesia for centromedian deep brain stimulation (DBS). APs from the same cell were pooled to obtain a mean AP (mAP). The amplitudes and durations for all 2/3 phases were computed from the mAP, together with the maximum (dVmax) and minimum (dVmin) values of the first derivative, as well as the slopes of different phases during repolarization. The mAPs are denominated according to the phase polarity (P/N for positive/negative). We obtained a total of 1109 mAPs, most of the positive (98.47%) and triphasic (93.69%) with a small P/N deflection (Vphase1) before depolarization. The percentage of the different types of mAPs was different for the nuclei addressed. The relationship between dVmax and the depolarizing phase is specific. The descending phase of the first derivative identified different phases during the repolarizing period. We observed a high correlation between Vphase1 and the amplitudes of either depolarization or repolarization phases. Human thalamic nuclei differ in their electrophysiological properties of APs, even under general anesthesia. Capacitive current, which is probably responsible for Vphase1, is very common in thalamic APs. Moreover, subtle differences during repolarization are neuron-specific.
3D Concrete Printing Sustainability: A Comparative Life Cycle Assessment of Four Construction Method Scenarios
Authors: Mohammad Malek , Masad Eyad , Al-Ghamdi Sami G.
Published: December 2020

Three-dimensional concrete printing (3DCP) has become recognized as a possible alternative to conventional concrete construction, mainly due to its potential to increase productivity and reduce the environmental impact of the construction industry. Despite its up-and-coming popularity within the field, limited research has quantitively investigated the environmental benefits that 3DCP brings. This paper investigates the environmental tradeoff of utilizing 3DCP over conventional construction by conducting a detailed cradle-to-gate life cycle assessment (LCA) study of four case-scenarios (conventional concrete construction, 3DCP with reinforcement elements, 3DCP without any reinforcement, and 3DCP without any reinforcement and utilizing a lightweight printable concrete material.) These case-scenarios were carefully selected to quantify the environmental impact of 3DCP while emphasizing the importance of the material composition. The LCA was conducted for a 1 m2 external load-bearing wall in all four scenarios. The LCA analysis showed that 3DCP significantly reduced environmental effects in terms of global warming potential (GWP), acidification potential (AP), eutrophication potential (EP), smog formation potential (SFP), and fossil fuel depletion (FFD), as compared to conventional construction methods. However, these environmental improvements diminished when 3DCP was coupled with the use of conventional reinforcement elements. Moreover, the use of an alternative concrete mixture in 3DCP showed a further decrease in the GWP, AP, EP, and FFD impact. Ultimately, the findings in this paper support the advantages of 3DCP technology and recommend the investigation of the development of (i) sustainable printable concrete materials and (ii) novel reinforcement techniques that are suitable for 3DCP rather than adopting conventional reinforcement techniques.
The Effect of Packing Material Properties on Tars Removal by Plasma Catalysis
Authors: Cimerman Richard , Cíbiková Mária , Satrapinskyy Leonid , Hensel Karol
Published: December 2020

Plasma catalysis has been utilized in many environmental applications for removal of various hydrocarbons including tars. The aim of this work was to study the tars removal process by atmospheric pressure DBD non-thermal plasma generated in combination with packing materials of various composition and catalytic activity (TiO2, Pt/γAl2O3, BaTiO3, γAl2O3, ZrO2, glass beads), dielectric constant (5–4000), shape (spherical and cylindrical pellets and beads), size (3–5 mm in diameter, 3–8 mm in length), and specific surface area (37–150 m2/g). Naphthalene was chosen as a model tar compound. The experiments were performed at a temperature of 100 °C and a naphthalene initial concentration of approx. 3000 ppm, i.e., under conditions that are usually less favorable to achieve high removal efficiencies. For a given specific input energy of 320 J/L, naphthalene removal efficiency followed a sequence: TiO2 > Pt/γAl2O3 > ZrO2 > γAl2O3 > glass beads > BaTiO3 > plasma only. The efficiency increased with the increasing specific surface area of a given packing material, while its shape and size were also found to be important. By-products of naphthalene decomposition were analyzed by means of FTIR spectrometry and surface of packing materials by SEM analysis.
Redox-Mediated Polymer Catalyst for Lithium-Air Batteries with High Round-Trip Efficiency
Authors: Kim Min-Cheol , Song Jung Hyun , Lee Young-Woo , Sohn Jung Inn
Published: December 2020

Lithium-air batteries (LABs) continue to receive attention as a promising power source because they possess a high theoretical energy density of 3436 Wh L−1. However, the remaining Li2O2 resulting from the irreversible decomposition of Li2O2 during the charge process is one of the key challenges so as to address the deterioration of the cycling performance of LABs. In this study, we propose and report a redox-mediated polymer catalyst (RPC) as a cathode catalyst being composed of LiI and poly (vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) with multi-wall carbon nanotubes (MWCNTs) as the cathode material. In the RPC, iodine molecules are chemically combined with the PVDF-HFP chain. The as-prepared RPC exhibits increased cycling performance by 194% and decreased overpotential by 21.1% at 0.1 mA cm−2 compared to the sample without LiI molecules. Furthermore, these results suggest that the RPC consisting of a polymer chain and redox mediators will be extensively utilized as highly efficient catalysts of LABs.
Antihistamines Increase Body Mass Index Percentiles and Z-Scores in Hispanic Children
Authors: Saad Michelle , Syed Sabeen , Ilyas Maheen , Gashev Anatoliy A.
Published: December 2020

The prevalence of childhood obesity has increased over the years in the United States and contributed to a rise in metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Animal studies suggested the role of histamine blockade on mesenteric lymphatics tone, contributing to weight gain and hepatic steatosis. This study aimed to investigate an association between antihistamines (AH) use in children and obesity. A single-center retrospective cohort study on children with a diagnosis of NAFLD, followed in the gastroenterology clinic, was performed between January 2018 and April 2019. The demographics, medications, and body mass index (BMI) were assessed. Participants were divided into an AH group with documented use and comparison group, antihistamine naïve. Of the 32 participants in the study, 13 used AH, and 19 did not. Antihistamine users had a mean increase in BMI percentile per year of 1.17 compared to a decrease of 0.06 in comparison group (p = 0.0008). AH usage correlated with a mean increase in BMI z-score of 0.23 per year, as opposed to a decrease by 0.012 in comparison group (p = 0.0016). No difference was found in triglycerides (TG), glucose, and liver enzymes. AH use increases BMI percentiles and z-scores over time and is associated with obesity in children.
Reinforced Superhydrophobic Anti-Corrosion Epoxy Resin Coating by Fluorine–Silicon–Carbide Composites
Authors: Zhang Zhicai , Zhao Nie , Qi Fugang , Zhang Biao , Liao Bin , Ouyang Xiaoping
Published: December 2020

SiC was modified by fluorine-containing organic substance 1H,1H,2H,2H-trifluoro-noctyltriethoxysilane (FAS) to change its hydrophilicity from hydrophilic to superhydrophobic nanoparticles, and the optimum conditions for hydrophobicity were effectively explored. Then, different content of fluorine-modified SiC (F–SiC) nanoparticles were added to the epoxy resin (EP) matrix to prepare composite coating samples. The results showed that the surface of SiC was modified by FAS to show superhydrophobicity, and the dispersion in EP was significantly improved. After adding F–SiC, the hydrophobicity, wear resistance and corrosion resistance of the coating were significantly improved. In addition, the corrosion resistance of the composite coating containing different contents of F–SiC was analyzed through electrochemical and salt spray tests. The results showed that the corrosion resistance of the coating was the best when the addition amount was 3 wt %. In general, the composite coating with 3 wt % F–SiC had the best overall performance. Compared with the EP coating, the water contact angle of 3 wt % F–SiC/EP composite coating was increased by 62.9%, the friction coefficient was reduced by 73.5%, and the corrosion current was reduced by three orders of magnitude. This study provides a new idea for the development of ultra-wear-resistant and anti-fouling heavy-duty coatings.
5-Iodo-1-Arylpyrazoles as Potential Benchmarks for Investigating the Tuning of the Halogen Bonding
Authors: Dumitrescu Denisa , Shova Sergiu , Man Isabela C. , Caira Mino R. , Popa Marcel Mirel , Dumitrascu Florea
Published: December 2020

5-Iodo-1-arylpyrazoles are interesting templates for investigating the halogen bond propensity in small molecules other than the already well-known halogenated molecules such as tetrafluorodiiodobenzene. Herein, we present six compounds with different substitution on the aryl ring attached at position 1 of the pyrazoles and investigate them in the solid state in order to elucidate the halogen bonding significance to the crystallographic landscape of such molecules. The substituents on the aryl ring are generally combinations of halogen atoms (Br, Cl) and various alkyl groups. Observed halogen bonding types spanned by these six 5-iodopyrazoles included a wide variety, namely, C–I⋯O, C–I⋯π, C–I⋯Br, C–I⋯N and C–Br⋯O interactions. By single crystal X-ray diffraction analysis combined with the descriptive Hirshfeld analysis, we discuss the role and influence of the halogen bonds among the intermolecular interactions.
Local and Landscape Compositions Influence Stingless Bee Communities and Pollination Networks in Tropical Mixed Fruit Orchards, Thailand
Authors: Wayo Kanuengnit , Sritongchuay Tuanjit , Chuttong Bajaree , Attasopa Korrawat , Bumrungsri Sara
Published: December 2020

Stingless bees are vital pollinators for both wild and crop plants, yet their communities have been affected and altered by anthropogenic land-use change. Additionally, few studies have directly addressed the consequences of land-use change for meliponines, and knowledge on how their communities change across gradients in surrounding landscape cover remains scarce. Here, we examine both how local and landscape-level compositions as well as forest proximity affect both meliponine species richness and abundance together with pollination networks across 30 mixed fruit orchards in Southern Thailand. The results reveal that most landscape-level factors significantly influenced both stingless bee richness and abundance. Surrounding forest cover has a strong positive direct effect on both factors, while agricultural and urbanized cover generally reduced both bee abundance and diversity. In the local habitat, there is a significant interaction between orchard size and floral richness with stingless bee richness. We also found that pollinator specialization in pollination networks decreased when the distance to the forest patch increased. Both local and landscape factors thus influenced meliponine assemblages, particularly the forest patches surrounding an orchard, which potentially act as a key reservoir for stingless bees and other pollinator taxa. Preservation of forest patches can protect the permanent nesting and foraging habitat of various pollinator taxa, resulting in high visitation for crop and wild plants.
Immune Checkpoint Inhibitors with or without Radiotherapy in Non-Small Cell Lung Cancer Patients with Brain Metastases: A Systematic Review and Meta-Analysis
Authors: Kim Dong Yeong , Kim Pyeong Hwa , Suh Chong Hyun , Kim Kyung Won , Kim Ho Sung
Published: December 2020

This study aimed to evaluate the radiologic response and adverse event rates of immune checkpoint inhibitor (ICI) therapy with or without radiotherapy for the treatment of non-small cell lung cancer (NSCLC) brain metastases. A systematic literature search was performed up to January 3, 2020. Studies evaluating the intracranial objective response rates (ORR) and/or disease control rates (DCR) of ICI with or without radiotherapy for treating NSCLC brain metastases were included. Consequently, twelve studies satisfied inclusion criteria. ICI combined with radiotherapy (pooled ORR, 95%; DCR, 97%) showed better local efficacy compared to ICI monotherapy (pooled ORR, 24%; DCR, 44%; p < 0.01 for both ORR and DCR). Grade 3 or 4 central nervous system (CNS)-related adverse event rates were not different (5% vs. 4%; p = 0.93). In conclusion, ICI combined with radiotherapy showed better intracranial efficacy than ICI monotherapy for treating NSCLC brain metastases. CNS-related grade 3 or 4 adverse event rate was not statistically different between the two groups. Several prospective trials are needed to compare the efficacy of ICI combined with radiotherapy and ICI monotherapy.
Characteristics of Fluorescent Intraoperative Dyes Helpful in Gross Total Resection of High-Grade Gliomas—A Systematic Review
Authors: Mazurek Marek , Kulesza Bartłomiej , Stoma Filip , Osuchowski Jacek , Mańdziuk Sławomir , Rola Radosław
Published: December 2020

Background: A very important aspect in the treatment of high-grade glioma is gross total resection to reduce the risk of tumor recurrence. One of the methods to facilitate this task is intraoperative fluorescence navigation. The aim of the study was to compare the dyes used in this technique fluorescent intraoperative navigation in terms of the mechanism of action and influence on the treatment of patients. Methods: The review was carried out on the basis of articles found in PubMed, Google Scholar, and BMC search engines, as well as those identified by searched bibliographies and suggested by experts during the preparation of the article. The database analysis was performed for the following phrases: “glioma”, “glioblastoma”, “ALA”, “5ALA”, “5-ALA”, “aminolevulinic acid”, ”levulinic acid”, “fluorescein”, “ICG”, “indocyanine green”, and “fluorescence navigation”. Results: After analyzing 913 citations identified on the basis of the search criteria, we included 36 studies in the review. On the basis of the analyzed articles, we found that 5-aminolevulinic acid and fluorescein are highly effective in improving the percentage of gross total resection achieved in high-grade glioma surgery. At the same time, the limitations resulting from the use of these methods are marked—higher costs of the procedure and the need to have neurosurgical microscope in combination with a special light filter in the case of 5-aminolevulinic acid (5-ALA), and low specificity for neoplastic cells and the dependence on the degree of damage to the blood–brain barrier in the intensity of fluorescence in the case of fluorescein. The use of indocyanine green in the visualization of glioma cells is relatively unknown, but some researchers have suggested its utility and the benefits of using it simultaneously with other dyes. Conclusion: The use of intraoperative fluorescence navigation with the use of 5-aminolevulinic acid and fluorescein allows the range of high-grade glioma resection to be increased.
Multimodality Approach for Endovascular Left Atrial Appendage Closure: Head-To-Head Comparison among 2D and 3D Echocardiography, Angiography, and Computer Tomography
Authors: Italiano Gianpiero , Maltagliati Anna , Mantegazza Valentina , Fusini Laura , Mancini Maria Elisabetta , Gasperetti Alessio , Brusoni Denise , Susini Francesca , Formenti Alberto , Pontone Gianluca , Fassini Gaetano , Tondo Claudio , Pepi Mauro
Published: December 2020

Background: Percutaneous left atrial appendage closure (LAAC) requires accurate pre- and intraprocedural measurements, and multimodality imaging is an essential tool for guiding the procedure. Two-dimensional (2D TOE) and three-dimensional (3D TOE) transoesophageal echocardiography, cardiac computed tomography (CCT), and conventional cardiac angiography (CCA) are commonly used to evaluate left atrial appendage (LAA) size. However, standardized approaches in measurement methods by different imaging modalities are lacking. The aims of the study were to evaluate the LAA dimension and morphology in patients undergoing LAAC and to compare data obtained by different imaging modalities: 2D and 3D TOE, CCT, and CCA. Methods: A total of 200 patients (mean age 70 ± 8 years, 128 males) were examined by different imaging techniques (161 2D TOE, 103 3D TOE, 98 CCT, and 200 CCA). Patients underwent preoperative CCT and intraoperative 2D and 3D TOE and CCA. Results: A significant correlation was found among all measurements obtained by different modalities. In particular, 3D TOE and CCT measurements were highly correlated with an excellent agreement for the landing zone (LZ) dimensions (LZ diameter: r = 0.87; LAA depth: r = 0.91, p < 0.001). Conclusions: Head-to-head comparison among imaging techniques (2D and 3D TOE, CCT, and CCA) showed a good correlation among LZ diameter measurements obtained by different imaging modalities, which is a parameter of paramount importance for the choice of the LAAC device size. LZ diameters and area by 3D TOE had the best correlation with CCT.
Changes in Short-Term and Ultra-Short Term Heart Rate, Respiratory Rate, and Time-Domain Heart Rate Variability Parameters during Sympathetic Nervous System Activity Stimulation in Elite Modern Pentathlonists—A Pilot Study
Authors: Gąsior Jakub S. , Hoffmann Bartosz , Silva Luiz Eduardo Virgilio , Małek Łukasz , Flatt Andrew A. , Baranowski Rafał , Werner Bożena
Published: December 2020

Monitoring of markers reflecting cardiac autonomic activity before and during stressful situations may be useful for identifying the physiological state of an athlete and may have medical or performance implications. The study aimed to determine group and individual changes in short-term (5 min) and ultra-short-term (1 min) heart rate (HR), respiratory rate (RespRate), and time-domain heart rate variability (HRV) parameters during sympathetic nervous system activity (SNSa) stimulation among professional endurance athletes. Electrocardiographic recordings were performed in stable measurement conditions (Baseline) and during SNSa stimulation via isometric handgrip in 12 elite modern pentathlonists. Significant increases in short-term HR and decreases in time-domain HRV parameters with no changes in RespRate were observed during SNSa stimulation. Significant differences were observed between Baseline (all minutes) and the last (i.e., 5th) minute of SNSa stimulation for ultra-short-term parameters. Analysis of intra-individual changes revealed some heterogeneity in responses. The study provides baseline responses of HR, RespRate, and time-domain HRV parameters to SNSa stimulation among elite pentathlonists, which may be useful for identifying abnormal responses among fatigued or injured (e.g., concussed) athletes. More attention to individual analysis seems to be necessary when assessing physiological responses to sympathetic stimuli in professional endurance athletes.