bluuebunny/crossref_metadata_2025 huggingface dataset:
A novel ligand transfer reaction: Transferring an N3-donor amine ligand from Ni(II) to Cu(II)—structural, spectral, theoretical, and docking studies
Authors: Mardani Zahra , Dorjani Sima , Moeini Keyvan , Darroudi Majid , Carpenter-Warren Cameron , MZ Slawin Alexandra , Woollins J Derek
Published: July 2019

Two complexes of N1-(2-aminoethyl)propane-1,3-diamine (AEPD), [Ni(AEPD)2](NO3)2 (1) and [Cu2( μ-Cl)2(AEPD)2](NO3)2·2H2O (2), are prepared and identified by elemental analysis, Fourier transform infrared spectroscopy and UV–Vis spectroscopy, and single-crystal X-ray diffraction (for 2). Spectral and structural data reveal that the AEPD ligand transfers from nickel to copper in the reaction between 1 and copper chloride. All coordination modes of the AEPD-based ligands are studied by analysis of the Cambridge Structural Database. The nickel atom in 1 has octahedral geometry (NiN6) while X-ray structure analysis revealed that the copper atom in the binuclear structure of 2 has an elongated square-pyramidal geometry with a CuN3OCl2 environment. In the crystal network of 2, water molecules and cationic complex units along with the nitrate ions form different hydrogen bond motifs. The thermodynamic stability of the compounds and their charge distribution patterns is studied by density functional theory and natural bond orbital analysis. The ability of AEPD and its complexes to interact with 10 selected biomacromolecules is investigated by docking calculations.
Drug therapy problems among patients with cardiovascular disease admitted to the medical ward and had a follow-up at the ambulatory clinic of Hiwot Fana Specialized University Hospital: The case of a tertiary hospital in eastern Ethiopia
Authors: Gelchu Tamene , Abdela Jemal
Published: July 2019

Background:

Pharmacotherapy is important in reducing morbidity and mortality related to cardiovascular diseases. However, these advantages are limited by drug therapy problems that can impact on a patient’s quality of life, prolong hospital stays, and increase the overall burden of healthcare expenditures. Therefore, this study was aimed to assess drug therapy problems among patients with cardiovascular diseases who were hospitalized and received follow-up at the ambulatory clinic of Hiwot Fana Specialized University Hospital.

Methods:

An institution-based cross-sectional study design was used to collect data from patients with cardiovascular diseases who were admitted to the medical ward and those who had received follow-up at the ambulatory clinic of Hiwot Fana Specialized University Hospital. The collected data were coded, entered, and analyzed using SPSS version 16. The associations of selected categorical variables were done using binary logistic and multivariate logistic regression analyses.

Results:

Out of 216 study participants, females accounted for 123 (57%), whereas 93 (43%) of them were males. Among cardiovascular diseases identified in the medical ward and ambulatory clinics of Hiwot Fana Specialized University Hospital, congestive heart failure 96 (44.4%) and hypertension 93 (43.1%) were the two most commonly diagnosed disorders. Of the total participants involved in the study, 131 (60.65%) had drug therapy problems. Among the seven classes of drug therapy problems assessed, the most commonly observed was the need for additional drug therapy 76 (58%); followed by cases related to unnecessary drug therapy and noncompliance both of which were estimated to be 16 (12.2%). In addition, of independent variables, only the use of more than three drugs was significantly associated in both binary logistic (crude odds ratio = 0.41, 95% confidence interval = 0.234–0.719, p = 0.002) and multivariate logistic regressions (adjusted odds ratio = 4.86, 95% confidence interval = 1.625–14.536, p = 0.005) as compared with those patients who were using less than three drugs.

Conclusion:

The findings of the study indicated that more than half of the study participants experienced drug therapy problems, for which 58% required additional drug therapy. The risk of drug therapy problem is found to increase with the use of more than three drugs. Since these problems are adversely affecting the treatment outcome of patients, this is an area which requires special attention and the cooperation of healthcare professionals to tackle it.
Negotiating the reuse of health-data: Research, Big Data, and the European General Data Protection Regulation
Authors: Starkbaum Johannes , Felt Ulrike
Published: July 2019

Before the EU General Data Protection Regulation entered into force in May 2018, we witnessed an intense struggle of actors associated with data-dependent fields of science, in particular health-related academia and biobanks striving for legal derogations for data reuse in research. These actors engaged in a similar line of argument and formed issue alliances to pool their collective power. Using descriptive coding followed by an interpretive analysis, this article investigates the argumentative repertoire of these actors and embeds the analysis in ethical debates on data sharing and biobank-related data governance. We observe efforts to perform a paradigmatic shift of the discourse around the General Data Protection Regulation-implementation away from ‘protecting data’ as key concern to ‘protecting health’ of individuals and societies at large. Instead of data protection, the key risks stressed by health researchers became potential obstacles to research. In line, exchange of information with data subjects is not a key concern in the arguments of biobank-related actors and it is assumed that patients want ‘their’ data to be used. We interpret these narratives as a ‘reaction’ to potential restrictions for data reuse and in line with a broader trend towards Big Data science, as the very idea of biobanking is conceptualized around long-term use of readily prepared data. We conclude that a sustainable implementation of biobanks needs not only to comply with the General Data Protection Regulation, but must proactively re-imagine its relation to citizens and data subjects in order to account for the various ways that science gets entangled with society.
The Relation Between Climatic Factors and Malaria Incidence in Sistan and Baluchestan, Iran
Authors: Mohammadkhani Minoo , Khanjani Narges , Bakhtiari Bahram , Tabatabai Seyed Mehdi , Sheikhzadeh Khodadad
Published: July 2019

Malaria is a major health problem in many tropical and subtropical countries and in the south of Iran. In this study, due to the importance of the disease in Sistan and Baluchestan province, the influence of temperature, humidity, and rainfall on malaria has been evaluated in areas with a high incidence of malaria. Malaria incidence data were inquired from the Province Health Authority, and climatic variables were inquired from the Bureau of Meteorology from 2000 to 2012 and were analyzed on a monthly basis. Changes in incidence of malaria with climatic factors were analyzed by negative binomial regression by Stata 11, and the correlations were calculated with Minitab15 for determining the potential impact of meteorological variables with and without lags on malaria transmission. The incidence of malaria had a significant positive correlation with the average, minimum, and maximum monthly temperatures and a negative correlation with rainfall and low humidity (<60%). However, humidity >60% had a positive impact on incidence; as in the town of Chabahar after adjusting variables such as rainfall and temperature; every one percent increase in humidity caused a 4% increase in malaria incidence in the same month and a significant 6% increase in the next month. Temperature and humidity over 60% are effective climate parameters in the incidence of malaria. These factors should be considered in planning for controlling and preventing malaria.
Intestinal lipid droplets as novel mediators of host-pathogen interaction inDrosophila
Authors: Harsh Sneh , Heryanto Christa , Eleftherianos Ioannis
Published: July 2019

Lipid droplets (LDs) are lipid carrying multifunctional organelles, which might also interact with pathogens and influence the host immune response. However, the exact nature of these interactions remains currently unexplored. Here we show that systemic infection of Drosophila adult flies with non-pathogenic E. coli, the extracellular bacterial pathogen P. luminescens or the facultative intracellular pathogen P. asymbiotica results in intestinal steatosis marked by lipid accumulation in the midgut. Accumulation of LDs in the midgut also correlates with increased whole-body lipid levels characterized by increased expression of genes regulating lipogenesis. The lipid enriched midgut further displays reduced expression of enteroendocrine secreted hormone, Tachykinin. The observed lipid accumulation requires the Gram-negative cell wall pattern recognition molecule PGRP-LC, but not PGRP-LE, for the humoral immune response. Altogether, our findings indicate that Drosophila LDs are inducible organelles, which can serve as marker for inflammation and depending on the nature of the challenge they can dictate the outcome of the infection.
Case Report: Penile necrosis associated to paraphimosis with calciphylaxis due to terminal chronic kidney disease
Authors: Grandez-Urbina J. Antonio , Corrales-Acosta Elizabeth , Tejeda-Mariaca J. Eduardo , Pichardo-Rodriguez Rafael , Garcia-Perdomo Herney
Published: July 2019

Background: Penile necrosis is a rare condition that may present in patients with diabetes mellitus or chronic kidney disease (CKD). The recommended treatment is controversial. We report a case of penile necrosis in a diabetic patient caused by episode of paraphimosis associated with uremic arteriopathy treated with partial amputation.

Clinical Case: A 53-year-old male with a background of arterial hypertension, diabetes mellitus and CKD in hemodialysis. The patient presented with paraphimosis and glans necrosis. An emergency circumcision was carried out. A doppler ultrasound found fluid collection in the left corpus cavernosum, parietal vascular calcifications and vascular insufficiency in the corpus cavernosum that suggested necrosis. A partial amputation of the penis was carried out. After three years of follow-up, the outcome has remained favorable.

Conclusions: Penile necrosis is a rare but serious complication of terminal CKD. In these patients, systemic calciphylaxis is usually observed. The main take-away lesson is that a multidisciplinary approach is necessary.
Iron Hack - A symposium/hackathon focused on porphyrias, Friedreich’s ataxia, and other rare iron-related diseases
Authors: Ferreira Gloria C. , Oberstaller Jenna , Fonseca Renée , Keller Thomas E. , Adapa Swamy Rakesh , Gibbons Justin , Wang Chengqi , Liu Xiaoming , Li Chang , Pham Minh , Dayhoff II Guy W. , Duong Linh M. , Reyes Luis Tañón , Laratelli Luciano Enrique , Franz Douglas , Fatumo Segun , Bari ATM Golam , Freischel Audrey , Fiedler Lindsey , Dokur Omkar , Sharma Krishna , Cragun Deborah , Busby Ben , Jiang Rays H.Y.
Published: July 2019

Background: Basic and clinical scientific research at the University of South Florida (USF) have intersected to support a multi-faceted approach around a common focus on rare iron-related diseases. We proposed a modified version of the National Center for Biotechnology Information’s (NCBI) Hackathon-model to take full advantage of local expertise in building “Iron Hack”, a rare disease-focused hackathon. As the collaborative, problem-solving nature of hackathons tends to attract participants of highly-diverse backgrounds, organizers facilitated a symposium on rare iron-related diseases, specifically porphyrias and Friedreich’s ataxia, pitched at general audiences.

Methods: The hackathon was structured to begin each day with presentations by expert clinicians, genetic counselors, researchers focused on molecular and cellular biology, public health/global health, genetics/genomics, computational biology, bioinformatics, biomolecular science, bioengineering, and computer science, as well as guest speakers from the American Porphyria Foundation (APF) and Friedreich’s Ataxia Research Alliance (FARA) to inform participants as to the human impact of these diseases.

Results: As a result of this hackathon, we developed resources that are relevant not only to these specific disease-models, but also to other rare diseases and general bioinformatics problems. Within two and a half days, “Iron Hack” participants successfully built collaborative projects to visualize data, build databases, improve rare disease diagnosis, and study rare-disease inheritance.

Conclusions: The purpose of this manuscript is to demonstrate the utility of a hackathon model to generate prototypes of generalizable tools for a given disease and train clinicians and data scientists to interact more effectively.
Which Healthy Eating Nudges Work Best? A Meta-Analysis of Field Experiments
Authors: Cadario Romain , Chandon Pierre
Published: July 2019

The effectiveness of healthy eating nudges in field settings increases as they shift from focusing on influencing cognition to affect to behavior.
M Analisis Manajemen Strategik Kepala MTs Ishlahul Muslimin Senteluk Lombok Barat Perspektif SWOT
Authors: Hanan Abdul
Published: July 2019

This research is a qualitative descriptive field research which examines the Principal’s Strategic Management Based on SWOT Analysis at the Islamic Junior High School ‘Ishlahul Muslimin’ in Senteluk, West Lombok. Data is collected through through observations, interviews, and documentation which is then analysed through data reduction, data display, and verification. The reseach subjects are the chairman of the school committee, the headmaster, the vice principals (curriculu affai; student affairs; public relations, facilities and infrastructure affairs) and teachers. This research aims to (1) describe the procedure of the MTs Ishlahul Muslimin’s Principal’s Strategic Management, (2) identify the implementation of SWOT analysis at MTs Ishlahul Muslimin Senteluk Lombok Barat, and (3) identify the internal and external factors related to MTs Ishlahul Muslimin’s program implementation. The results of this study indicate that : (a) the principal’s Strategic Management is considered to be innovative and flexible, (b) the implementation of SWOT analysis at MTs Ishlahul Muslimin Senteluk Lombok Barat has three phases: strategy formulation, strategy implementation, and strategy evaluation, and (c) the internal factors related to the program implementation at MTs Ishlahul Muslimin are learner analysis, educators analysis and curriculum analysis. The external factors include the analysis of the social environment of the community and the analysis of the role of government.
Economic Analysis: Trickling Filter/Activated Sludge or Nitrifying Trickling Filter/Activated Sludge?
Authors: Jafarinejad Shahryar
Published: July 2019

The performance and economic simulation and modeling are crucial for accurate and rapid designing, construction, and forecasting future economic needs of municipal wastewater treatment plants (MWWTPs). In this study, combined nitrifying trickling filter/activated sludge (NTF/AS) process was suggested for the modernization of a MWWTP and the performance and economics of MWWTPs based on the combined TF/AS process and combined NTF/AS process were analyzed and compared. In real, the performance, total project construction, total operation labor, total maintenance labor, total material, total chemical, total energy, and total amortization costs of these proposed MWWTPs were calculated and compared. Under the used design criteria and operational conditions in this study, the project construction cost of the MWWTP based on TF/AS was 15.25 % higher than that of the MWWTP based on NTF/AS. Also, MWWTP based on NTF/AS was cost effective and the material and amortization costs for both plants were higher in comparison with the operation, maintenance, energy, and chemical costs. It is necessary to note that this study is a computer simulation for a case and drawing general conclusions only on the basis of this simulation may be insufficient.
Physicochemical and Antimicrobial Properties of Hydroxypropyl Methylcellulose-Cinnamon Essential Oil Emulsion: Effects of Micro- and Nanodroplets
Authors: Li Shuzhi , Zhou Jingyang , Wang Yanan , Teng Anguo , Zhang Kai , Wu Zinan , Cheng Shan , Wang Wenhang
Published: July 2019

Emulsion is an efficient encapsulation tool for enhancing the functional properties of essential oils (EOs). Herein, two two-dimensional cinnamon essential oil emulsions (from micro- to nanoscales) were emulsified by hydroxypropyl methylcellulose, and their antimicrobial and physicochemical properties were investigated. For the models of Escherichia coli CGMCC 1.0907, Salmonella enterica subsp. Enterica serovar Typhi (CICC 10867), Staphylococcus aureus CGMCC 1.0089, and Listeria monocytogene CGMCC 1.9144, the minimum inhibitory concentration (MIC) of the nanoemulsion was 31.25 μL/mL compared to that of the microemulsion (62.5–125 μL/mL) and pure oil (125–250 μL/mL), indicating the superiority of nanoemulsion as an antibacterial agent. The results showed that the highest activity was seen in the gram-positive L. monocytogenes whereas the lowest was in the gram-negative S. enterica. The identified properties of HPMC (hydroxypropyl methylcellulose) provide the potential for emulsifying and enhancing essential oils in light industries, especially for food processing.
Comparison and assessment of zeolite catalysts performance dimethyl ether and light olefins production through methanol: a review
Authors: Kianfar Ehsan
Published: July 2019

The present review focuses on a comparison and assessment of zeolite catalyst performance of dimethyl ether and light olefin production through methanol. Dimethyl ether is a clean fuel which needs diverse processes to be produced. Methanol to dimethyl ether is a very novel process which offers considerable advantages versus additional processes for the production of dimethyl ether. The corresponding fixed-bed reactors compose the most important section of such a process. Production of dimethyl ether by the mentioned process is of high importance since it can be catalytically transferred to a substance with the value of propylene. Furthermore, in case of capability to transfer low-purity methanol into dimethyl ether, less expensive methanol can be consequently achieved with higher value added. In the petrochemical industry, light olefins, for example, ethylene and propylene, can be used as raw materials for the production of polyolefin. The present review aims to produce dimethyl ether in order to reach olefin substances, initially conducting a compressive assessment on production methods of olefin substances.
APLICACIONES EDUCATIVAS EN SECUNDARIA PARA LA PREVENCIÓN DE LA CRIMINALIZACIÓN ESTUDIANTIL: UN ENFOQUE DESDE LA JUSTICIA RESTAURATIVA Y LOS DERECHOS HUMANOS
Authors: De Mézerville López Claire , Meza Rodríguez Ana Estrella , Ochoa Theresa A , Ovares Fernández Yanúa
Published: July 2019

El siguiente artículo aborda la intervención desde la disciplina positiva como una alternativa a las reacciones punitivas comunes ante las faltas escolares calificadas como graves y muy graves, que aboga por un abordaje más humano. Este se respalda desde una perspectiva de derechos humanos basada en un encuadre de justicia restaurativa. El artículo enfatiza la importancia de 1) procesos justos centrados en el estudiante; 2) participación estudiantil activa en los procesos disciplinarios, 3) apoyo en lugar de solo sanción hacia adolescentes con problemas de conducta y 4) un enfoque destinado a fortalecer las relaciones entre estudiantes con esta problemática y docentes que previenen o atienden las faltas. Casos selectos de un colegio público costarricense se utilizan para ilustrar los beneficios de prácticas más humanizadas. El artículo propone que un abordaje restaurativo no es necesariamente sustituto para las medidas correctivas acostumbradas, sino más bien una manera de mayor efectividad para contribuir a que las personas consideradas perpetradoras, asuman la responsabilidad por sus actos y se mantengan involucradas en el sistema educativo, en lugar de aislarlas al punto en que se impliquen en faltas más frecuentes y severas.
Centrifuge study on the effect of pile bending stiffness on the slope stabilised by piles
Authors: Lei Guoping , Wu Wei
Published: July 2019

The stability and failure of a slope stabilised by piles are influenced by the pile bending stiffness. In this paper, the effect of the bending stiffness is studied by centrifuge model tests. Two kinds of piles made of aluminium and acrylic tubes are chosen to represent relatively rigid and flexible piles, respectively. The piles are installed in a row at various pile-spacing ratios in a slope with an inclination of 45°. The model slope consists of a compacted inclined soil layer sliding on a stable wooden structure along a prescribed slip surface. Strain gauges are installed on an aluminium pile to obtain the bending moment. Images taken during the test from the side and the top are used to monitor the soil and pile displacements. The results show that the slope is well stabilised by aluminium piles with small spacing. In the case of relatively flexible piles, the top part of the pile becomes ineffective and the slope stability is reduced.
Creencias sobre salud y prácticas de autocuidado en adultos jóvenes: estudio biográfico de estilos de vida
Authors: Galdames Cruz Susan , Jamet Rivera Paulina , Bonilla Espinoza Alexander , Quintero Carvajal Francisca , Rojas Muñoz Valerie
Published: July 2019

El abundante acceso a información y recomendaciones para el autocuidado de la salud a través de los medios de comunicación y los programas de salud pública no han logrado aumentar la adherencia de la población a estilos de vida saludables. A pesar de los avances en esta materia, las enfermedades no trasmisibles asociadas a estilos de vida insanos siguen siendo una epidemia a nivel mundial. Objetivo: Para comprender uno de los factores psicosociales relevantes para el autocuidado de la salud se estudió en profundidad las creencias de profesionales jóvenes chilenos sobre salud y sobre sus prácticas de autocuidado. Materiales y métodos: Mediante un estudio cualitativo basado en el paradigma fenomenológico y el método biográfico se analizó las historias de vida de 14 adultos jóvenes profesionales que trabajan en distintas áreas laborales. Resultado: En base a un análisis de contenido se muestra que los jóvenes manifiestan creencias favorables hacia un estilo de vida saludable, pero a nivel de sus prácticas de autocuidado ellos mantienen algunas conductas no saludables. Es así como, independientemente del conocimiento científico que manejan sobre salud, los jóvenes generan una estructura argumentativa personal que les permite autojustificar la inconsistencia entre sus creencias y sus prácticas de autocuidado. Conclusiones: Estos hallazgos plantean la necesidad de redirigir el foco de las intervenciones de promoción de estilos de vida saludables.
Mentoring Characteristics and Functions Important to Men and Women within Intercollegiate Athletic Administration
Authors: Bower Glenna , Hums Mary , Williams Sarah
Published: July 2019

Female athletic administrators were asked about the role of mentoring in their careers as women while male athletic administrators were asked about the role of mentoring in their careers as men working in intercollegiate athletic administration.  The researchers gathered and compared information on mentor characteristics as well as career and psychosocial benefits of having a mentor. Participants were 518 female and 778 male athletic administrators working at NCAA Division I, II, and IIII, NAIA, NCCAA, and NJCAA schools. A three-step content-analytic procedure was used to analyze the qualitative data.

Men identified being trustworthy, supportive, respected, and a good listener while women identified being supportive, hardworking, and knowledgeable as the most important mentor characteristics. Men most frequently named coaching and challenging assignments as career benefits from mentors while women named exposure/visability and coaching. Both men and women most frequently identified counseling and role modeling as psychosocial benefits from mentors.
DEL ESPEJO DE AGUA A LA GLOBALIZACIÓN 2.0
Authors: Barbosa Fernando
Published: July 2019

Lo que se pretende en este ensayo no es otra cosa que aproximar una reflexión sobre la China de ayer y hoy. Y, específicamente, sobre lo que sabemos y lo que se nos está informando ahora con tanto entusiasmo por todos los medios, entramando los desarrollos actuales, pero también de la imagen y del pensamiento tal como han ido evolucionando a través del tiempo. De otra parte, se busca incentivar la autocrítica frente a los estudios e investigaciones que se llevan a cabo en nuestro entorno y que con frecuencia reflejan un cierto acomodo a tesis y teorías que se aceptan con poca resistencia. Si China constituye un gran reto en términos de su capacidad para conformar el mundo del mañana, el reto que tenemos para ajustar nuestras herramientas analíticas parece ser aún mayor. De tal manera, lo que se quiere es invitar a una reflexión sosegada a partir de elementos que se han acumulado en varios siglos y que ayudan a explicar algunos de los sesgos con que tratamos de descifrar lo sínico.
China-Japan bilateral relations: the unforgettable result of history
Authors: Aristizábal Carolina
Published: July 2019

This research has the purpose of analyzing the sino-japanese bilateral relations since World War II until now, specifically from the aspects and facts that have affected it politically. In that sense, first, the Second Sino-japanese War is presented as the initial point for evaluating this relationship in the XX century; afterwards, the article evidences the main characteristics of the chinese and japanese foreign policy in the first two decades of the XXI century; finally, the text examines both countries position towards the North Korean nuclear program.
A multi-scale model of cardiac electrophysiology v1
Authors: clancy Colleen , not provided Pei-Chi , Aghasafari Parya
Published: July 2019

Multi-scale computational modeling is a major branch of computational biology as evidenced by the US federal interagency Multi-Scale Modeling Consortium and major international projects. It invariably involves specific and detailed sequences of data analysis and simulation, often with multiple tools and datasets, and the community recognizes improved modularity, reuse, reproducibility, portability and scalability as critical unmet needs in this area. Scientific workflows are a well-recognized strategy for addressing these needs in scientific computing. While there are good examples if the use of scientific workflows in bioinformatics, medical informatics, biomedical imaging and data analysis, there are fewer examples in multi-scale computational modeling in general and cardiac electrophysiology in particular. Cardiac electrophysiology simulation is a mature area of multi-scale computational biology that serves as an excellent use case for developing and testing new scientific workflows. In this dataset, we develop, describe and test a computational workflow that serves as a proof of concept of a platform for the robust integration and implementation of a reusable and reproducible multi-scale cardiac cell and tissue model that is expandable, modular and portable. The workflow described leverages Python and Kepler-Python actor for plotting and pre/post-processing. During all stages of the workflow design, we rely on freely available open-source tools, to make our workflow freely usable by scientists.
The Exiles: Native Survivance and Urban Space in Downtown Los Angeles
Authors: Black Liza
Published: July 2019

The 1961 independent film The Exiles is remarkable for many reasons. Nonprofessional Native actors played themselves, created their own dialogue, and developed the storyline, for example, and the film positions itself as documentary and ethnography in ways that validate these Native interventions. Although The Exiles is fundamentally a portrait of American Indian life in Los Angeles, readings from film and urban studies primarily focus on filmmaking technique. As a result of this critical focus, the film's significance in regard to the cultural agency and urban history of Native peoples becomes secondary, and urban Natives are erroneously depicted as anomalous as well. Looking closely at Yvonne Williams, the female Native protagonist, I find that the film embodies Native American survivance through capturing an urban experience that was controlled by Native people more than any other filmic representation up to that point. This article argues for the tremendous import of The Exiles by highlighting the ways in which it challenges expectations of modern Indian people.
Painting Native America in Public: American Indian Artists and the New Deal
Authors: Rosenthal Nicolas G.
Published: July 2019

The New Deal represents a critical period in the development of American Indian art. Shifts in policy created opportunities for American Indians to study art, and New Deal commissions for murals in post offices and other public spaces enabled artists to develop skills, establish their reputations, and make a living. American Indian artists also faced challenges in the form of dominant expectations for Native art and paternalism from officials and administrators. The benefits of New Deal commissions and the struggles with their limitations nonetheless formed a foundation for subsequent generations of Native artists who claimed more control over their art.
Introduction
Authors: Rosenthal Nicolas G. , Black Liza
Published: July 2019

Together, the articles in this special issue of the American Indian Culture and Research Journal offer a discussion of how Indigenous peoples have represented themselves and their communities in different periods and contexts, as well as through various media. Ranging across anthropology, art history, cartography, film studies, history, and literature, the authors examine how Native people negotiate with prominent images and ideas that represented Indians in the dominant culture and society in the United States and the Americas. These essays go beyond the problems of cultural appropriation by non-Indians to probe the myriad ways Native Americans and Indigenous people have challenged, reinforced, shifted, and overturned those representations.
Synthesis of Poly-Sodium-Acrylate (PSA) Coated Magnetic Nanoparticles for Use in Forward Osmosis Draw Solutions
Authors: Ban Irena , Markuš Sabina , Gyergyek Sašo , Drofenik Miha , Korenak Jasmina , Helix-Nielsen Claus , Petrinić Irena
Published: July 2019

The synthesis of magnetic nanoparticles (MNPs) coated with hydrophilic poly-sodium-acrylate ligands (PSA) was studied to assess PSA-MNP complexes as draw solution (DS) solutes in forward osmosis (FO). For MNP-based DS, the surface modification and the size of the MNPs are two crucial factors to achieve a high osmolality. Superparamagnetic nanoparticles (NP) with functional groups attached may represent the ideal DS where chemical modifications of the NPs can be used in optimizing the DS osmolality and the magnetic properties allows for efficient recovery (DS re-concentration) using an external magnetic field. In this study MNPs with diameters of 4 nm have been prepared by controlled chemical co-precipitation of magnetite phase from aqueous solutions containing suitable salts of Fe2+ and Fe3+ under inert atmosphere and a pure magnetite phase could be verified by X-ray diffraction. Magnetic colloid suspensions containing PSA coated MNPs with three different molar ratios of PSA : MNP = 1:1, 1:2 and 1:3 were prepared and assessed in terms of osmotic pressure, aggregation propensity and magnetization. FTIR confirmed the presence of PSA on coated MNPs and pristine PSA-MNPs with a molar ratio PSA : MNP = 1:1 exhibited an osmotic pressure of 30 bar. Molar ratios of PSA : MNP = 1:2 and 1:3 lead to formation of less stabile magnetic colloid solutions which led to formation of aggregates with larger average hydrodynamic sizes and modest osmotic pressures (5.5 bar and 0.2 bar respectively). After purification with ultrafiltration, the 1:1 nanoparticles exhibited an osmotic pressure of 9 bar with no aggregation and a sufficient magnetization of 25 emu/g to allow for DS regeneration using an external magnetic field. However, it was observed that the amount of PSA molecules attached to the MNPs decreased during DS recycling steps leaving only strong chelate bonded core-shell PSA as coating on the MNPs. This demonstrates the crucial role of MNP coating robustness in designing an efficient MNP-based DS for FO.
N-Heterocyclic Carbene-Platinum Complexes Featuring an Anthracenyl Moiety: Anti-Cancer Activity and DNA Interaction.
Authors: Harlepp Sébastien , Chardon Edith , Bouché Mathilde , Dahm Georges , Maaloum Mounir , Bellemin-Laponnaz Stéphane
Published: July 2019

A platinum (II) complex stabilized by a pyridine and a N-heterocyclic carbene ligand featuring an anthracenyl moiety was prepared. The compound was fully characterized and its molecular structure was determined by single-crystal X-ray diffraction. The compound demonstrated high in vitro antiproliferative activities against cancer cell lines with IC50 ranging from 10 to 80 nM. The presence of the anthracenyl moiety on the NHC Pt complex was used as a luminescent tag to probe the metal interaction with the nucleobases of the DNA through a pyridine-nucleobase ligand exchange. Such interaction of the platinum complex with DNA was corroborated by optical tweezers techniques and liquid phase AFM microscopy. The results revealed a two-state interaction between the platinum complex and the DNA strands. This two-state behaviour was quantified from the different experiments due to contour length variations. At 24h incubation, the stretching curves revealed multiple structural breakages, and AFM imaging revealed a highly compact and dense structure of platinum complexes bridging the DNA strands.
SERAPAN KARBON LAMUN Thalassia hemprichii PADA BEBERAPA KEDALAMAN
Authors: Mashoreng Supriadi , Alprianti Sheryl , Samad Wasir , Isyrini Rantih , Inaku Dwi Fajriati
Published: July 2019

Ekosistem padang lamun merupakan ekosistem yang umum ditemukan di Kepulauan Spermonde, salah satunya adalah Gusung Bonebatang. Lamun mempunyai kemampuan menyerap karbon untuk proses fotosintesis sehingga berpotensi dalam  mitigasi perubahan iklim.  Penelitian dilakukan pada bulan Agustus 2017 untuk membandingkan penyerapan karbon oleh jenis Thalassia hemprichii  pada beberapa kedalaman perairan. Sampel lamun diambil pada daerah subtidal, kemudian daun lamun dibersihkan dari sedimen dan epifit. Metode perubahan oksigen digunakan untuk mengestimasi serapan karbon. Sebanyak 1 tunas T. hemprichii diinkubasi menggunakan botol kaca bening 70 ml. Inkubasi dilakukan pada jam 09.00-12.00 WITA pada kedalaman 50, 100, 150, 200 dan 250 cm dengan masing-masing 5 kali ulangan setiap kedalaman. Sebelum inkubasi, dilakukan pengukuran konsentrasi oksigen terlarut di perairan sebagai kandungan oksigen awal. Pengukuran oksigen di dalam botol bening kembali dilakukan setelah inkubasi. Selain oksigen terlarut, dilakukan juga pengukuran konsentrasi bikarbonat pada awal dan akhir inkubasi. Sebagai kontrol, inkubasi juga dilakukan pada air laut (mengandung fitoplankton) dengan 5 kali ulangan. Daun lamun yang telah digunakan untuk pengamatan serapan karbon diukur luasnya dengan cara men-scan daun lamun dan dianalisis menggunakan software Imaje-J. Selanjutnya dilakukan pengeringan menggunakan oven dan ditimbang untuk mengetahui biomassa keringnya. Hasil penelitian menunjukkan bahwa serapan karbon per tunas berkisar antara 0,928-1,476 mgCO2/tunas/jam, per biomassa berkisar 10,647-25,745 mgCO2/gbk/jam, dan per luas daun berkisar 0,010-0,024 mgCO2/cm2/jam. Serapan karbon tertinggi didapatkan pada kedalaman 200 cm, baik serapan karbon per tunas, biomass maupun luas daun.
APLIKASI EDIBLE FILM MAIZENA DENGAN PENAMBAHAN EKSTRAK JAHE SEBAGAI ANTIOKSIDAN ALAMI PADA COATING SOSIS SAPI
Authors: Manuhara Godras Jati , Kawiji Kawiji , E Heny Ratri
Published: July 2019

Penambahan ekstrak jahe yang mengandung antioksidan alami ke dalam pembuatan edible coating sosis diharapkan mampu mengurangi kerusakan lemak pada produk sosis. Penelitian ini memiliki dua tujuan. Pertama, Mengetahui konsentrasi penambahan ekstrak jahe pada edible coating sosis yang paling disukai oleh panelis.
Kedua, mengetahui pengaruh penambahan ekstrak jahe pada edible coating sosis terhadap tingkat kerusakan lemak sosis selama penyimpanan. Berdasarkan uji yang dilakukan pada aplikasi edible coating sosis, yakni uji organoleptik, uji susut
berat, dan uji kerusakan oksidatif lemak, diketahui bahwa perlakuan paling baik adalah penambahan ekstrak jahe pada edible coating sosis sebesar 10%.
Kata Kunci: antioksidan,edible film, maizena
PENGARUH KONSENTRASI AGAR-AGAR DAN KARAGENAN TERHADAP KARAKTERISTIK FISIK, KIMIA, DAN SENSORI SELAI LEMBARAN JAMBU BIJI MERAH (Psidium guajava L.)
Authors: Septiani Ika Nur , Basito Basito , Widowati Esti
Published: July 2019

Selai lembaran jambu biji merah (Psidium guajava L.) dalam penelitian ini dibuat dengan variasi jenis
(agar-agar dan karagenan) dan konsentrasi (1,5%, 2,0%, dan 2,5%) hidrokoloid dengan tujuan untuk mengetahui
pengaruh konsentrasi agar-agar dan karagenan terhadap karakteristik fisik, kimia, dan sensori serta mengetahui
perlakuan yang menghasilkan karakteristik selai lembaran terbaik. Analisis yang dilakukan meliputi evaluasi
karakteristik fisik (nilai pH dan total padatan terlarut), kimia (kadar air dan serat pangan), dan sensori. Metode
penelitian menggunakan Rancangan Acak Lengkap satu faktor yaitu kombinasi jenis hirdokoloid dengan
konsentrasinya. Berdasarkan hasil penelitian, perbedaan jenis hidrokoloid berpengaruh signifikan terhadap nilai
pH, total padatan terlarut, dan kadar serat pangan, serta berpengaruh namun tidak signifikan terhadap kadar air
dan sensori. Perbedaan konsentrasi hidrokoloid berpengaruh signifikan terhadap kadar serat pangan serta
berpengaruh namun tidak signifikan terhadap pH, total padatan terlarut, kadar air, dan sensori selai lembaran.
Penambahan kedua jenis hidrokoloid tersebut menyebabkan peningkatan nilai pH, kadar air, dan kadar serat
pangan total namun menurunkan total padatan terlarut. Perlakuan agar-agar konsentrasi 1,5% menghasilkan selai
lembaran terbaik dengan nilai pH 3,25, total padatan terlarut 31 Brix sukrosa, kadar air 35,3264% wb, kadar
serat pangan total 5,0979%, dan memiliki aroma, rasa, dan overall yang paling disukai.
PENGARUH PENGEMASAN VAKUM TERHADAP KUALITAS BANDENG PRESTO SELAMA PENYIMPANAN
Authors: Purnamayati Lukita , Wijayanti Ima , Dwi Anggo Apri , Amalia Ulfah , Sumardianto Sumardianto
Published: July 2019

Softbone milkfish is a fishery product that easily damaged during storage. One of the efforts to inhibit the
damage of softbone milkfish was using vacuum packaging. The purpose of this study was to determine the
changes quality of softbone milkfish which were vacuum packed during storage at room temperature. Fresh
milkfish was heating with high pressure by using a pressure cooker. Softbone milkfish was then stored at room
temperature for six days. Analysis was carried out every three days for the parameters of free fatty acids, TVBN,
and organoleptics. The results showed that the number of free fatty acids and TVBN increased during storage.
Free fatty acids and TVBN of softbone milkfish with vacuum packaging after sixth days of storage were 2.95%
and 15.95 mgN/100g, respectively. This value was lower than the non-vacuum softbone milkfish. Based on
organoleptic analysis, softbone milkfish with vacuum packaging was still suitable for consumption until the third
day of storage. This showed that vacuum packaging can extend the shelf life of softbone milkfish.
Linkage to Hepatitis C Care After Incarceration in Jail: A Prospective, Single Arm Clinical Trial
Authors: Akiyama Matthew Jiro , Columbus Devin , MacDonald Ross , Jordan Alison O , Schwartz Jessie , Litwin Alain H , Eckhardt Benjamin , Carmody Ellie
Published: July 2019

Background: Hepatitis C virus (HCV) is a major public health problem in correctional settings. HCV treatment is often not possible in U.S. jails due to short lengths of stay. Linkage to care is crucial in these settings, but competing priorities complicate community healthcare engagement and retention after incarceration.

Methods: We conducted a single arm clinical trial of a combined transitional care coordination (TCC) and patient navigation intervention and assessed the linkage rate and factors associated with linkage to HCV care after incarceration.

Results: During the intervention, 84 participants returned to the community after their index incarceration. Most participants were male and Hispanic, with a history of mental illness and a mean age of 45 years. Of those who returned to the community, 26 (31%) linked to HCV care within a median of 20.5 days; 17 (20%) initiated HCV treatment, 15 (18%) completed treatment, 9 (11%) had a follow-up lab drawn to confirm sustained virologic response (SVR), and 7 (8%) had a documented SVR. Among those with follow-up labs the known SVR rate was (7/9) 78%. Expressing a preference to be linked to the participant’s existing health system, being on methadone prior to incarceration, and feeling that family or a loved one were concerned about the participant’s wellbeing were associated with linkage to HCV care. Reporting drinking alcohol to intoxication prior to incarceration was negatively associated with linkage to HCV care.

Conclusion: We demonstrate that an integrated strategy with combined TCC and patient navigation may be effective in achieving timely linkage to HCV care. Additional multicomponent interventions aimed at treatment of substance use disorders and increasing social support could lead to further improvement.
SAFE Hi-C: A Simplified, Amplification-free and Economically Efficient High-throughput Chromosome Conformation Capturing Method
Authors: Niu Longjian , Huang Yingzhang , Hou Chunhui
Published: July 2019

PCR amplification of Hi-C libraries introduces unusable duplicates and results in a biased representation of chromatin interactions. We present a simplified, fast, and economically efficient Hi-C library preparation procedure that generates sufficient non-amplified ligation products for deep sequencing. Comprehensive analysis of the resulting data indicates that amplification-free Hi-C preserves higher complexity of chromatin interaction and lowers sequencing depth dramatically for the same number of unique paired reads. With amplification bias avoided, our method may produce a chromatin interaction network more faithfully reflecting the real three-dimensional genomic architecture.
Pediatric congenital buttock sinus tract: 10-year experience in a single institution
Authors: Wang Kai , Peng Chunhui , Pang Wenbo , Wang Dayong , Zhang Tingchong , Wang Zengmeng , Wu Dongyang , Chen Yajun
Published: July 2019

Background: Pediatric congenital buttock sinus tract has rarely been reported, and the manifestations, treatments, and prognosis of such patients remain unknown. The purpose of this study is to review our experience with this disease, and to conclude the clinical characteristics and management of the disease.
Methods: Twenty-two pediatric patients diagnosed with congenital buttock sinus tract were included. Medical records were reviewed, and the patients were followed up. Data were presented using the mean ± standard deviation, median (first quartile, third quartile), frequencies and percentages as appropriate.
Results: Among the 22 patients, there were 8 boys (36.4%) and 14 girls (63.6%). First onset age was 42.00 (12.00, 84.00) months, admission age was 77.77 ± 40.73 months, and overall prior treatment time was 11.00 (6.50, 33.75) months. Twenty-one patients had definite congenital dimples since birth, and later manifested with infection through the dimple. All patients came to the doctor with complaint of the infection. The number of invasive procedures ranged from 0 to 5, with an average of 2. Radiology could exactly display the morphology and show the termination as a retrorectal cyst. The surgical procedure was adopted trans-fistula tract, and the pathological results showed a dermoid cyst in 11 patients and an epidermoid cyst in 10 patients. During the follow-up period of 34.50 (24.25, 87.50) months, 19 patients were uneventful and 3 patients suffered recurrence. Two of them underwent a second operation and had no recurrence ever since. The third patient did not receive a second operation, and the refractory infection was still present.
Conclusions: Pediatric congenital buttock sinus tract is rare and has a female predominance in the morbidity. Patients have a distinctive congenital dimple on the buttock with recurrent infection, and there usually exists a congenital sinus tract from the dimple to the retrorectal space. Total excision is the only method for the cure. The nature of the disease is a retrorectal developing dermoid cyst or epidermoid cyst.
Keywords: Pediatric, Buttock sinus tract, Retrorectal cyst, Treatment, Prognosis
Neonatal Mortality and its Determinates in Public Hospitals of Gamo and Gofa Zones, Southern Ethiopia: Prospective Follow up Study
Authors: Mersha Abera , Bante Agegnehu , Shibiru Shitaye
Published: July 2019

Background

The neonatal period is the most vulnerable time for a child survival. The declines in the neonatal mortality rate have been slower than post-neonatal under-five mortality rate in the majority of countries. This this trend is also similar in Ethiopia, that neonatal mortality was high as compare to post neonatal mortality rate. A large proportion of neonatal deaths occur during the 48 hours after delivery. Different studies was conducted in assessing determinates for neonatal mortality but there is a need to assess the immediate post-partum (within two days following delivery) cause of neonatal mortality that the majority of deaths occurred that time. So, this study is to fill those gaps of aforementioned studies, in assessing the determinate factors affecting neonatal mortality in public hospitals of Gamo and Gofa Zones, Southern Ethiopia.

Methods

A prospective follow up study was conducted among 6,986 study participants from April 5, 2018 to March 5, 2019. Data on causes of neonatal death were collected by using structured verbal autopsy questionnaire. Data were entered in to Epi data version 3.1 and exported to Stata version 15 for analysis. Crude and adjusted estimate β with 95%CI was calculated in the binary logistic regression model. The goodness of fit was tested by log likelihood ratio (LR). In this study P-value < 0.05 was considered to declare a result as statistically significant association.

Results

In this study neonatal mortality incidence ratio was 9.6 (95%CI: 7.5%, 12.2%) per 1000 live births. Age of the mother, number of antenatal care, hemorrhage, sex of the neonate, presentation, gestational age and birth weight were identified as the significant determinates for neonatal mortality cases. Prematurity, infection and birth asphyxia were the most common causes of neonatal mortality cases.

Conclusions

This study indicated that a significant number of neonates were died during neonatal period. Both maternal and neonatal factors were identified. Therefore, early identification of obstetric complications and immediate interventions, strengthening the provision of quality antenatal and postnatal care services are recommended.