bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison between Frequency Response of Pulsating Partially Premixed and Diffusion Flame
Authors:   Ph.D. Candidate Dept., Fac. Of Eng. Ain Shams University, Egypt., Moustafa A.M. , Kamal M.M. ,   Prof. of Mechanical Power Dept., Fac. Of Eng. Ain Shams University, Egypt., Hamed Ashraf M. ,   Professors (Assistant) Dept., Fac. Of Eng. Ain Shams University, Egypt., Hussin Ahmed E ,   Dept., Fac. Of Eng. Ain Shams University, Egypt.
Published: November 2020

The objective of the current research is investigation of the pulsating flow effect on the size of partially premixed and diffusion flame, experimentally. The pulsation provided through a rotary ball valve in accordance with a variable speed motor arrangement increased the flame temperature and thus more heat is released. The used S-type thermocouple can measure the flame temperature at strouhal number [St] is 0 and 0.005 for the flow, the flame temperature has been measured at five planes as each plane has five radii. Fast Fourier Transform (FFT) has been used to determine the dominant frequency response of the pulsating flame temperatures. Increasing strouhal number of the mixture (LPG fuel and air) flow increases the turbulence intensity and thus the dominant frequency response of the pulsating flame increases. The dominant frequency at St=0 is larger than the dominant frequency at St= 0.005 for all the planes of the combustion chamber. Increasing strouhal number reduces the size of the pulsating partially premixed and diffusion flame by a maximum of 40 and 35 %, respectively. The pulsation process will optimize design of the burners.
Women's Wearable Security and Safety Device
Authors:   Department of Computer Science and Engineering, Nitte Meenakshi Institute of Technology, Bangalore., Anisha S.K. , Chandana S. ,   Department of Computer Science and Engineering, Nitte Meenakshi Institute of Technology, Bangalore., Teresa J.J. ,   Department of Computer Science and Engineering, Nitte Meenakshi Institute of Technology, Bangalore.,   Department of Computer Science and Engineering, Nitte Meenakshi Institute of Technology, Bangalore., Varma S. , Thippeswamy M. N. ,   Department of Computer Science and Engineering, Nitte Meenakshi Institute of Technology, Bangalore.
Published: November 2020

In today’s world, one of the major issues that women all across the globe face is threats to their safety and security. This paper presents a quick safety device that responds immediately when women are in danger. The device is equipped with a button and on pressing the button, a “HELP” message is sent along with the location coordinates to the trusted contacts via an SMS. The device is also capable of capturing an image and a video which can then be analyzed to identify the perpetuator. When a woman feels threatened or she finds herself in a compromising situation, she can use this device for her safety.
Addressing Security Requirements through Onshore Agile Development When Packaging Software in the Distributed Development Domain An empirical study
Authors:   Computer Science, College of Computers and Information Technology, Taif University, Taif, Saudi Arabia., Qahtani Abdulrahman M.
Published: November 2020

Designing software for use by multiple clients has become commonplace in the software sector and has led to many vendors focusing on developing software for a specific sector, marketing the product then modifying it to a customer’s requirements. To fit the software to the client’s needs involves a unique form of teamwork, and it is usually an offshore team that processes the requests and implements the changes to the initial infrastructure. Unfortunately, this contravenes organizations’ information security requirements, due to their multiple structures and infrastructures and their need for privacy as well as swift processing of requests at reasonable cost. This study proposes a hybrid model, the Onshore Agile Security Requirements Development (OASRD) model, which uses Agile to meet the security implications arising from the onshore team working at the client’s site while it processes the customization requirements. It investigates the impact of the model on productivity, measured by the number of security and customization requirements that are processed and the estimated cost in terms of human resources. The evaluation reveals a statistically significant increase in productivity of about 40%, accompanied by a reduction in cost of more than 48% over the entire customization process, demonstrating the advantages of customizing packaged software through distributed development.
Qualitative Analysis of Consumer Redressal Practices in Indian Regulated Sectors
Authors:   Research Associate, Symbiosis Institute of Digital & Telecom Management (SIDTM), Pune (Maharashtra), India., Mujumdar Ms. Mugdha , Prabhu Dr. Sandeep ,   Associate Professor, Symbiosis Institute of Digital & Telecom Management (SIDTM), Pune (Maharashtra), India., Hallur Dr. Giri ,   Associate Professor, Symbiosis Institute of Digital & Telecom Management (SIDTM), Pune (Maharashtra), India.
Published: November 2020

This paper aims to study and analyseconsumer complaint resolution mechanisms and ombudsman frameworks in three Indian regulated sectors and tries to compare it with that of telecom sector. Here an analysis of regulatory data is carried out. The paper is both theoretical and analytical in nature.This research sheds light on complaint resolution frameworks in Indian regulated sectors such as “Banking, Insurance, Electricity and telecom. Role of Ombudsman and alternates dispute resolution mechanism in the sector is also studied. It is necessary for Ombudsman to perform its duties and responsibilities for overall growth of the sector.Visible, sharp complaint resolution structure and noticeable, orderly decision making entity are truly necessary component of complaint solving mechanism. This Paper also analyses statistics, facts of complaint resolution rates etc. Consumer complaint solving framework is a regulatory vehicle for discarding of grievances. This research is indicator of eight principles of effective consumer resolution mechanism.
Design and Development of Microcontroller Based Electromagnetic Induction Injera Mitad Prototype
Authors:   Lecturer, Electrical Power and Control Engineering, ADAMA Science and Technology University, Ethiopia., M. Feleke Fanta
Published: November 2020

Injera is flat, thin, soft, usually circular bread like staple food for most Ethiopians. Its cooking process islong and sensitive to environmental conditions. Injera baking requires temperature ranging from 150oC to 180oC. To generate this temperature, most people use biomass products, whereas thosehaving access to grid connection use locally manufactured traditional electric injera mitad which uses Nickel–Chrome resister as heat source. This electric clay mitad consumesat an average 3 – 3.5 KWand has low efficiency. To improve power consumption and efficiency of injera cooking mitad, the author developed Electromagnetic Induction Injera Mitad prototype. The prototype operation is based on laws of electromagnetic induction. After complete assembly of the components, a series of lab and field tests were conducted and it was observed that, for a similar injera quality, the initial heating up time was reduced to 45%, the power consumption was reduced to 50%, and the efficiency was increased around 30% comparedto that of traditional electric injera mitad.
Designing Time Series Crime Prediction Model using Long Short-Term Memory Recurrent Neural Network
Authors:   Department of Computer Science and Engineering, Adama Science and Technology University, Adama, Ethiopia., Meskela Tsion Eshetu ,   Department of Information Systems, Wolkite University, Wolkite, Ethiopia., Afework Yidnekachew Kibru , Ayele Nigus Asres ,   Department of Information Technology, Wolkite University, Wolkite, Ethiopia., Teferi Muluken Wendwosen ,   Department of Information Technology, Wolkite University, Wolkite, Ethiopia., Mengist Tagele Berihun ,   Department of Software Engineering, Wolkite University, Wolkite, Ethiopia.
Published: November 2020

Crime influences people in many ways. Prior studies have shown the relationship between time and crime incidence behavior. This research attempts to determine and examine the relationship between time, crime incidences types and locations by using one of the neural network models for time series data that is, Long Short-Term Memory network. The collected data is pre-processed, analyzed and tested using Long Short-Term Memory recurrent neural network model. R-square score is also used to test the accuracy. The study results show that applying Long Short-Term Memory Recurrent Neural Network (LSTM RNN) enables to come up with more accurate prediction about crime incidence occurrence with respect to time. Predicting crimes accurately helps to improve crime prevention and decision and advance the justice system.
Concordancia de la filtración glomerular estimada según las fórmulas utilizadas en Colombia en pacientes con enfermedad renal crónica no en diálisis
Authors: Coronado Daza Jorge Antonio , Fragozo Ramos María Carolina , Reyes Fontalvo Lina Fernanda
Published: November 2020

Introducción: las guías colombianas de enfermedad renal crónica (ERC) recomiendan estimar la filtración glomerular (FG) con la fórmula de Epidemiología de la Enfermedad Renal Crónica (CKD-EPI). No se han realizado estudios que comparen en la población colombiana la exactitud de esta fórmula con otras utilizadas en la práctica clínica.

Diseño y Métodos: En 757 pacientes adultos evaluamos el desempeño para estimar la FG por las fórmulas de la Modificación de la Dieta en la Enfermedad Renal (MDRD4), Cockroft-Gault (CG) y Cockroft-Gault corregida para la superficie corporal (CG-SC) comparada con la fórmula de CKD-EPI. El desempeño se evaluó con mediciones del sesgo, precisión y exactitud.

Resultados: La media de la FG por CKD-EPI fue 37.32±12.71 ml/min/1.73m2, por MDRD4 de 39.8±13.2 ml/min/1.73m2, por CG fue 35±12.6 ml/min y por CG-SC de 34.52±11.34 ml/min/1.73m2.  Todas las fórmulas tuvieron un sesgo con relación a la FG por CKD-EPI. La fórmula más precisa y más exacta fue la MDRD4 que sólo difirió una proporción>15% y del 30% en el 2.9% y 0.26% de las mediciones respectivamente y la menos exacta fue la FG estimada por CG que difirió en el 40.3% y 18.23% de las mediciones. El coeficiente de correlación entre la FG por CKD-EPI y MDRD4 fue de 0.97, con CG y CG-SC de 0.78 y 0.85, respectivamente.

Conclusiones: la fórmula alterna más exacta para estimar la filtración glomerular en esta población colombiana es la MDRD-4 que tiene una alta concordancia con la fórmula de CKD-EPI. Se sugiere no utilizar la estimación de la FG con la fórmula de CG.
Caracterización de los pacientes con endocarditis infecciosa en población de Boyacá
Authors: Barón-Barón Javier Orlando , Rozo-Ortiz Edwar Jassir , Martínez-Mariño María Mónica , Najar-Molano Fransol , Vargas Rodriguez Ledmar Jovanny , Márquez-Rosales Benjamín Alexánder
Published: November 2020

La endocarditis infecciosa (EI) es una enfermedad multisistémica que resulta de una infección, generalmente bacteriana, de la superficie endocárdica. Su incidencia es de tres a nueve casos por cada 100 000 personas.

Objetivo: realizar una caracterización de los pacientes atendidos en el Hospital Universitario San Rafael de Tunja con diagnóstico de endocarditis infecciosa.

Material y métodos: estudio observacional descriptivo. Pacientes atendidos en el Hospital Universitario San Rafael de Tunja entre el 1º. de enero del 2010 a 1º. de enero del 2019. Se tomaron variables sociodemográficas, clínicas, paraclínicas, imagenológicos, terapéuticas y de desenlaces.

Resultados: en total se atendieron 87 personas que presentaron diagnóstico confirmado de endocarditis infecciosa. La edad promedio fue 38.77 años con una DE ± 13.32 años. Se observó leucocitosis en 90%, neutrofilia en 85%, linfocitosis en 3%, trombocitopenia en 4%, aumento de los valores séricos de PCR en 85%, transaminitis en 45%, hiponatremia en 2% e hipernatremia en 4%. Todos los pacientes recibieron manejo antibiótico, tan solo 23% requirieron manejo quirúrgico.

Conclusiones: en esta serie de casos se encontraron características clínicas y microbiológicas similares a lo reportado en otras investigaciones nacionales e internacionales. Afectando con mayor frecuencia a personas del sexo masculino, siendo el principal agente causal el Staphylococcus aureus, el agente causal. La fiebre y los signos de vasculitis infecciosa fueron las principales manifestaciones clínicas, afectado con mayor frecuencia la válvula mitral.
A STUDY TO COMPARE THE EFFECTIVENESS OF TIMOLOL 0.5% VERSUS BRIMONIDINE 0.2% FOR CONTROL OF RISE IN INTRAOCULAR PRESSURE AFTER ND-YAG LASER CAPSULOTOMY
Authors: kalla Chandan , Prasnnta Prasnnta
Published: November 2020

Purpose: A study to compare the effectiveness of Timolol 0.5% eye drops versus Brimonidine 0.2 % eye drops for control of rise in intraocular pressure after Nd-YAG laser capsulotomy.
Study design: Randomized controlled trial.
Methods: The study was done on 80 patients (one eye of each patient) of age group 45 to 70 year with posterior capsular opacification planned for Nd-YAG laser capsulotomy in the Department of Ophthalmology Mathuradas Mathur Hospital (Dr S. N. M. C.) Jodhpur. Patients were divided into two groups X and Y of 40 each. The baseline intraocular pressure of all patients was measured by applanation tonometer before instillation of eye drops. Group X instilled one drop of Timolol 0.5% and group Y instilled 1drop of Brimonidine 0.2% one hour before capsulotomy. Intraocular pressure was noted 1 and 4 hour after the laser procedure.
Results: There were 40 patients in each group. The baseline IOP was 16±2.16 for group X, and 15±2.56 for group Y. There was no statistically significant reduction between the two groups in the mean IOP changes at 1 hour after Nd-YAG laser capsulotomy but after 4 hours, the mean reduction in IOP was -1.54 mmHg for group X and -1.85 for group Y (p<0.5).
Conclusion:
Our study revealed that both Timolol 0.5% eye drops and Brimonidine 0.2% eye drops are comparatively equally effective in controlling raised intraocular pressure after Nd-YAG laser capsulotomy.
Adalberto Alves e l'aforisma
Authors: Graziani Michela
Published: November 2020

The aphorism is the literary form choosen by the Portuguese poet Adalberto Alves in the collection A presença dos dias / La presenza dei giorni. The essay aims to analyse the concept of aphorism in Adalberto Alves with an eastern and western philosophical view.
TINGKAT PENGETAHUAN PASIEN TENTANG EFEK SAMPING OBAT CAPTOPRIL DAN AMLODIPIN DI PUSKESMAS SUNGAI JINGAH
Authors:   Akademi Farmasi ISFI Banjarmasin, Ariani Novia , Febrianti Dwi Rizki , Niah Rakhmadhan
Published: November 2020

Hypertension is an increase in systolic and diastolic blood pressure of more than 140 mmHg and90 mmHg. Captopril and Amlodipin are the most commonly used antihypertensive drugs, especially in Sungai Jingah Health Center. Long-term use is most likely to cause side effects. The level of knowledge of patients about side effects is very influential in knowing the early signs of the emergence of side effects and can prevent complications caused by side effects. The purpose of this study was to determine the level of patient knowledge about the side effects of captopril and amlodipine drugs at Sungai Jingah Health Center. This research is a non-experimental observational study. The population used was all hypertensive patients who received captopril and amlodipine drugs at the Sungai Jingah Health Center in April-May 2019. Samples were taken with consecutive sampling techniques that met the inclusion criteria of 55 patients. The research instrument used a questionnaire sheet that had been tested for validity and reliability consisting of 4 statements about the side effects of captopril and 5 items about the side effects of amlodipine. The data obtained is recapitulated and calculated using the percentage formula for each statement then presented descriptively. The results of the research on the level of knowledge about the side effects of captopril and amlodipine showed that out of 55 respondents 80.00% had a low level of knowledge, 3.64% had sufficient knowledge and 16.36% had good knowledge. The conclusion of this study is that the level of knowledge of patient knowledge about the side effects of captopril and amlodipine is in the low category (80.00%).
EVALUASI RASIONALITAS PENGGUNAAN DAN PEMBERIAN OBAT PADA PASIEN HIPERTENSI GERIATRI DI PUSKESMAS TAJINAN PERIODE JANUARI – DESEMBER 2019
Authors:   STIKes Panti Waluya Malang, Anisyah Luluk , Wibowo Wibowo
Published: November 2020

Increasing the number of elderly causes an increase in health problems one of which is associated with hypertension which can cause complications and death. The purpose of this study was to determine the description and accuracy of the use of antihypertensive drugs in geriatric patients who were diagnosed with hypertension at the Tajinan Primary Health in Malang in the period January-December 2019. This study was an observational or non-experimental study conducted using retrospective medical record data. The measuring instrument used was the data collection sheet from the medical record, the Consensus for Hypertension Management 2019 to see the accuracy of indications, patient accuracy, drug accuracy, and dose accuracy. Data analysis using Correlation Test. The results of the correlation analysis showed that the resulting Standardize estimates were 0.002 (p <0.05) which showed that there was a significant relationship between sexes with the occurrence of hypertension. The results of the correlation analysis showed that the resulting Standardize estimates were 0.001 (p <0.05) which means that there was a significant relationship between the accuracy of the types of antihypertensive drugs used in hypertensive patients. The conclusion is that the rationality evaluation of the use and administration of drugs in hypertensive patients at the Tajinan Primary Health in Malang based on the 2019 Hypertension Management Consensus guidelines shows the accuracy both in terms of indication, drug, patient and dose.
Physician engagement in regularly scheduled rounds
Authors: Bass Adam , Armson Heather , McLaughlin Kevin , Lockyer Jocelyn
Published: November 2020

Background: Physician participation in regularly scheduled series (RSS), also known as grand rounds, was explored with a particular focus on physician perceptions about the elements that affected their engagement in RSS and the unanticipated benefits to RSS.

Methods: A qualitative study using semi-structured interviews and thematic analysis examined physicians’ perception of their knowledge and educational needs and the factors that contributed to engagement in their local hospital RSS.

Results: Physician engagement in RSS was affected by four major themes: Features that Affect the RSS’ Quality; Collegial Interactions; Perceived Outcomes of RSS; and Barriers to participation in RSS. Features that Affect RSS’ Quality were specific modifiable features that impacted the perceived quality of the RSS. Collegial Interactions were interactions that occurred between colleagues directly or indirectly as a result of attending RSS. Outcomes of RSS were specific outcome measures used in RSS sessions. Barriers were seen as reasons why physicians were unwilling or unable to participate in RSS. All of the elements identified within the four themes contributed to the development of physician engagement. Physicians also identified changes directly and indirectly due to RSS.

Discussion: Specific features of RSS result in enhanced physician engagement. There are benefits that may not be accounted for in continuing medical education (CME) outcome study designs
Covid-19: Distanciamiento Social, sus Efectos Psicológicos y 10 Estrategias para Sobrellevarlo
Authors: Vides Alonzo Rory René , Alegria Barrow Eileen Mariemilia , Morales Guerra Isolina Janeth , Sagastume Roque Carlos Junior , Montejo Galdámez Juan Danilo
Published: November 2020

El estado de alerta decretado por el gobierno para hacer frente a la crisis sanitaria en la que nos encontramos en relación a la expansión del coronavirus (COVID-19), obligó a cambios en los patrones de comportamiento y detenimiento del funcionamiento habitual del dí­a a dí­a. Cuando la situación dura más de unas pocas semanas, a menudo surgen problemas de salud relacionados con el aislamiento social. El brote de la enfermedad por coronavirus 2019 (COVID-19) puede causar estrés en algunas personas, la ansiedad por la pandemia puede ser abrumadora y causar fuertes emociones en adultos y niños. En efecto, esta situación tiene una potente carga psicológica sobre nosotros.

Durante la pandemia, es razonable esperar que las enfermedades mentales se vean afectadas de diferentes formas por aislamiento prolongado. Los efectos más frecuentes son: Depresión paranoide, Esquizofrenia residual, Trastorno esquizoide de la personalidad, entre otras. Demasiada información puede provocarnos estrés, ansiedad u angustia que afecta nuestro estado emocional, que nos lleva a realizar diversas comprobaciones, como buscar información nueva y actualizada. Para mitigar estos factores estresores y sus posibles consecuencias, existen algunas estrategias que pueden utilizarse para prevenir y reducir los efectos del aislamiento.
La Medicina Tradicional entre los Maya-Kiché de San Andrés Xecul, Totonicapán
Authors: Osorio López Carlos Romeo
Published: November 2020

En esta tesis, se conjuga la investigación antropológica con la experiencia de campo, ofreciendo un material de reflexión acerca de la medicina tradicional entre los Maya-K’iche’ del Occidente de Guatemala. En este trabajo de investigación están presentes temas de gran relevancia como los referentes a la relación entre los conocimientos locales, propios de las comunidades indí­genas herederas de un saber ancestral a lo largo de la historia, pero también se ve atacada ante el peso económico de la medicina occidental.
Monogeneans and Trematodes of some Fishes from Lake Hamrin in Diyala Province, Iraq
Authors: Al-Jawda Jawdat M. , Ali Maan H.
Published: November 2020

Between January and December 2019, a total of 368 fish specimens were collected from Lake Hamrin in Diyala province, Iraq. Eight species of these fishes belonged to the family Cyprinidae, five to the family Leuciscidae as well as one species each to Bagridae, Heteropneustidae, Siluridae, Mugilidae and Mastacembelidae. After the laboratory examination these fishes were found to be infected with 30 monogeneans and two trematode species. The monogeneans included one species each of Mastacembelocleidus, Paradiplozoon, Solostamenides, and Thaparocleidus, two species of Dogielius, four species of Gyrodactylus and 20 species of Dactylogyrus, while the trematodes included one species each of Ascocotyle which infects eight fish species and Clinostomum which infect nine fish species. Clinostomum complanatum infected nine host species, also, the results of the present study revealed that 15 parasite species infect only one host species each. Carassius auratus was infected with 18 parasite species and Cyprinus carpio with nine species. Eight fish species are reported here as new host records in Iraq for 13 parasite species.
Complete Genome Sequence and Evaluation of Expression Level for Genes Associated with Virulence for a Clinical Brucella Melitensis Strain C-573 Isolated in Russia
Authors: Dmitry A. Kovalev  , Sergey V. Pisarenko  , Anna Yu. Evchenko  , Dmitry G. Ponomarenko  , Olga V. Bobrysheva  , Andrei M. Zhirov  , Irina V. Kuznetsova  , Diana V. Rusanova  , Alexander N. Kulichenko
Published: November 2020

Brucellosis is one of the most pressing global zoonotic diseases, which is endemic in many regions of the world. It is believed that Brucella melitensis is the most pathogenic species of Brucella genus for humans. However, the processes underlying the pathogenicity of this pathogen remain not fully understood. In our study, we report on the first complete genome of the clinical B. melitensis strain isolated in Russia, perform structural and functional analysis of the genomic sequence, and evaluate the expression level of genes associated with virulence based on Next Generation Sequencing (NGS) data. The obtained information on the genetic similarities and differences between B. melitensis strains can be used to study the mechanisms responsible for the pathogenicity of Brucella spp., as well as in the process of developing new therapeutic and preventive strategies for controlling brucellosis.
PROFESSOR ANATOLY ANDREEVICH BABANIN (THE 80TH ANNIVERSARY)
Authors: Fominykh T. A. , Kutsevol B. L. , Kisel’ev V. V. , Zakharova A. N. , Ulanov V. S. , Saenko A. G. , Gritskevich O. Yu.
Published: November 2020

The article is dedicated to the 80th anniversary of the Doctor of Medical Sciences (MD), Professor Anatoly Andree- vich Babanin. The article highlights the main events in the life of the famous scientist, lists the main achievements and scientific achievements. The life and scientific activities of Anatoly Andreevich are inextricably linked with the Crimean Medical Institute (University), within the walls of which the future professor first received a higher medical education, and then, after years of successful scientific activity, headed the university as a rector for many years. Thanks to the talented leadership, the Crimean Medical University has reached a high level of scientific and technological develop- ment and international recognition. For long productive work and scientific achievements, Professor A.A. Babanin awarded numerous government and international awards and titles, and currently continues active work for the benefit of higher medical education in Crimea.
FEATURES OF METABOLIC COUPLING IN THE «SUPERORGANISM» SYSTEM (HOST – MICROBIOTA)
Authors: Shestopalov A. V. , Shatova O. P. , Komarova E. F. , Rumyantsev S. A.
Published: November 2020

Today, it is believed that the human body and the intestinal microbiota exist in a metabolic coupling based on the principle of mutualism. The main metabolic function of the intestinal microbiotic population is the hyperproduction of short-chain fatty acids, which perform an energy function for both microorganisms and human cells, regulate the quo- rum and participate in the response of immune cells of the macroorganism through specific signaling mechanisms. Also, a characteristic link in the metabolic coupling of the «superorganism» is the metabolic pathways of tryptophan and, respectively, indoles, kynurenines and serotonin. Indole acts as an interspecific signaling molecule and is respon- sible for both the bacterial quorum and, for example, regulates the differentiation of nerve tissue. Many metabolic path- ways of tryptophan conversion are amplified by the microbiotic community, but the formation of kynurenic acid, which is a signal molecule in energy metabolism, is characteristic only for the macroorganism. It should be noted the role of membrane bacterial vesicles in the interaction of the host and the microbiota as carriers of virulence factors and other modulators of the function of macroorganism cells. Despite a significant amount of research, the metabolic coupling of the «macroorganism – gut microbiota» system remains poorly understood. In this regard, the purpose of this review was to highlight some aspects of the metabolic interaction of the macroorganism and its microbiota.
THE MULTILINGUAL TURN IN SLA AND THE PRAXIS OF DECOLONIAL FISSURE
Authors: Sugiharto Setiono
Published: November 2020

Recent debates over the notion of the multilingual turn in applied linguistics in general and Second Language Acquisition (SLA) in particular clearly reflect the robustness of the notion in the fields. Yet, what is often ignored in the debate is the fact the notion itself is by nature problematic, and, as a consequence, the discussion of its realization in the fields of applied linguistics and SLA is fraught with disputes. In this article, I will first revisit the notion of the multilingual turn in order to show the contentious nature of the term, and then go on to suggest that we need to shy away from creating a division of labor between scholars from the global South and North, as has been propounded by Mendoza (2019); instead, we need to invest our efforts to ponder over more nuanced and situated actions which must be carried out by scholars from the global South to reform the above disciplines through “the praxis of decolonial fissure” (Walsh, 2018).
ROLE OF SCREENING IN EPIDEMIOLOGY MANAGEMENT FOR LUNG CANCER IN THE KRASNOYARSK REGION
Authors: Safontsev Ivan , Zukov Ruslan , Modestov Andrey , Slepov Yevgeniy , Son Irina , Laricheva I.
Published: November 2020

The paper presents data of multifactorial Cancer Registry analysis of lung cancer incidence in the city of Krasnoyarsk and the Krasnoyarsk Region for the period from 2004 till 2014. The authors show the economic efficiency of the screening programs for the lung cancer risk target group, among the inhabitants of the city of Krasnoyarsk. The group was determined on the base of long-term analysis of register data, as well as international experience. The article shows the economic calculations of the cost and effectiveness of screening program that are proposed for the target population as early lung cancer detection.
DYNAMICS OF OBSERVED AND RELATIVE SURVIVAL OF COLON CANCER PATIENTS IN ST. PETERSBURG AND THE REPUBLIC OF BELARUS (ACCORDING TO POPULATION-BASED CANCER REGISTRIES)
Authors: Merabishvili Vakhtang , Okeanov Aleksey , Yevmenenko Alesya
Published: November 2020

Actuality of problem. Analysis of observed and relative survival is related to important criteria for evaluation of cancer control at the population-based level covering all patients on the administrative territory as well as the group of treated patients. Comparison of the effectiveness of treatment of patients in different countries allows revealing more adequate methods of complex anti-cancer activities. In this paper such study was carried out with respect to colon cancer according to population-based cancer registries of the Republic of Belarus and St. Petersburg.
Purpose of study is to compare dynamics of observed and relative survival rates in colon cancer patients in the Republic of Belarus and St. Petersburg.
Materials and methods. In the basis of the study there were taken databases of population-based cancer registries of the Republic of Belarus and St. Petersburg and also there was used standard methodology by constructing expectancy tables and estimating the significance of differences in rates. Analysis of obtained data. There was performed in-depth comparative analysis of dynamics of survival rates by sex, age and histological tumor types.
Conclusion. Conducted comparative study of survival colon cancer patients in the Republic of Belarus and St. Petersburg showed significant growth of rates however relative survival in Europe was much higher than in the Republic of Belarus and western regions of Russia.
METASTATIC COLORECTAL CANCER MCRC WITH WILD-TYPE RAS: THE CONTINUATION OF ANTI-EGFR THERAPY WITH A CHANGE OF CHEMOTHERAPY AFTER DISEASE PROGRESSION
Authors: Kit Oleg , Vladimirova Lyubov , Abramova Nataliya , Storozhakova Anna , Popova Irina , Tikhanovskaya Natalya
Published: November 2020

The effeciency and safety of continuing of EGFR-inhibition while switching the chemotherapy (CT) for patients with RAS wild-type metastatic colorectal cancer (mCRC) were analyzed. 20 patients were recruited. The therapy included: the 1st-line with FOLFOX-6+Cetuximab until progression, then FOLFIRI+ Cetuximab as the 2nd-line therapy. Response rate (RR), toxicity, PFS and OS were evaluated. The control group (20 patients) with 1st-line with FOLFOX-6+anti-EGFR drugand changing of chemotherapy on irinotecan-containing regimen with Bevaci-zumab after progression was used for the comparison of RR, PFS, and OS. OS in patients of study group was higher than in historical control: 29.0±3.4vs22.0±3.1 months, р=0.0458. Continued therapy anti-EGFR drugs in mCRC with wild-type RAS while switching chemotherapy deserves futher evaluation in additional studies in EGFR-dependent mCRC pts.
POSSIBILITY TO REDUCE THROMBOCYTOPENIA AFTER CHEMORADIOTHERAPY IN ONCOLOGICAL PATIENTS
Authors: Korytova Luiza , Meshechkin Aleksey , Korytov Oleg , Krasnikova V.
Published: November 2020

Objective was to establish efficiency of sodium nucleospermat in correcting thrombocytopenia after chemoradiotherapy in oncological patients.
Methods and materials. The study included data on 32 patients that had undergone combined treatment from January till May 2016. After detecting thrombocytopenia patients were randomized into two groups (16 patients in each): treated group, where patients received sodium nucleospermat, and control group, where sodium nucleospermat was not used. Thrombocyte level control was done on 5th, 10th and 15th day after treatment was over.
Results and discussion. All 16 patients showed positive dynamics in increasing thrombocyte level after Sodium nucleospermat injection course was finished. This was proven by first (5th day) blood analysis. On average thrombocyte level after sodium nucleospermat treatment has risen to normal, at 161х109/1. Only 3 patients from this group had to pause radiotherapy for 5 days. Control group patients, which did not receive sodium nucleospermat, showed evidence of thrombocyte level recovery by 10th day only. On average thrombocyte level increase was insignificant, and median number was 111*109/l. Low thrombocyte level was main reason to pause radiotherapy for 11 (69%) patients in control group.
Conclusion. Sodium nucleospermat allowed raising thrombocyte level to the lower normal range, which surpassed by 40%-50% in control group patients. Use of sodium nucleospermat did not show any cases of allergic reactions, toxicity or complications in oncological patients.
GLIOBLASTOMA MULTIFORME: PATHOGENESIS AND MOLECULAR MARKERS
Authors: Kit Oleg , Vodolazhskiy Dmitriy , Frantsiyants Yelena , Panina Svetlana , Rastorguev E. , Porksheyan D.
Published: November 2020

Glioblastoma multiforme (GBM) is the most common and invasive poorly differentiated brain tumor with nearly 100 % rate of recurrence and unfavorable prognosis. The aim of the present review is to analyze recent studies and experimental results (Scopus, Web of Science, PubMed) concerning somatic mutations in glioblastoma, aberrant regulation of gene expression of signal pathways including EGFR, TGFß, etc. and markers for GBM progression. Particularly the molecular subtypes of glioblastoma and NGS results are considered in this review.
MULTI-RESISTANT CARBAPENEM-INSENSITIVE GRAMNEGATIVE BACTERIA IN PATIENTS WITH SOLID TUMORS
Authors: Polishchuk Anna , Yakubovich Yelena , Osovskikh Viktor , Yevtushenko Vladimir , Polukhina O.
Published: November 2020

Infections caused by multiresistant gram-negative bacteria are one of the major problems in the treatment of cancer patients. Strains with mechanisms of resistance mediated by carbapenemases represent a particular threat since they spread rapidly and are characterized by high frequency of occurrence of multiresistance to antimicrobial agents. Here we show that 14 out of 399 gram-negative bacteria (3,5 %), isolated from clinical specimens of 11 patients with solid tumors (n=581) in a hospital of federal level in January 2015-April 2016 were carbapenem-insusceptible. Among them 3 isolates of Klebsiella pneumonia, 2 Enterobacter cloacae, 2 Pseudomonas aeruginosa and 7 Acinetobacter baumannii. All 14 strains were resistant to a wide range of antimicrobial agents including beta-lactams, aminoglycosides, monobactams and fluoroquinolones. The only antimicrobial agent to which all but one Exloacae strain remained susceptible was colistin. This strain was insusceptible to all 10 antimicrobial agents tested in the study, including tigecycline. We observed two cases of infection of a single patient by 2-3 distinct species of multidrug-resistant gram-negative bacteria. In 79 % of the strains the genes encoding carbapenemases of OXA40/24, KPC, VIM and NDM types were detected. Despite the fact that multidrug-resistant car-bapenem-insusceptible strains of gram-negative bacteria were isolated from a relatively small number of cancer patients, the majority of these strains represent a particular epidemiological and clinical threat.
MODELING OF SOLID LIVER CANCER IN A RABBIT
Authors: Panchenko Andrey , Plakhov Yevgeniy , Gubareva Yekaterina , Guzevatykh Lyudmila , Khitrin K. , Balabanyan V.
Published: November 2020

Possibilities of the liver tumor modeling were assessed in rabbits of Soviet Chinchilla strain by implantation into the left lobe of the liver slices of squamous cell VX2 tumor obtained from donor rabbits inoculated with the tumor in the thigh muscles. The basic parameters of the model were established - the dynamics of tumor growth, inoculation rate, incidence of concomitant abdominal tumors. There was offered a method for minimally invasive monitoring of the development of the tumor after implantation to the liver by means of the level of venous blood granulocytes. It was found that the most appropriate way to diagnose liver tumors in rabbits was computed tomography scan.
POLYSACCHARIDES OF TUSSILAGO FARFARA L. AS COMPONENTS OF CHEMOTHERAPY SCHEME
Authors: Safonova Yelena , Lopatina Kseniya , Fedorova Yelena , Rybalkina Olga , Razina Tatyana , Gurev Artem , Belousov Mikhail , Zueva Yelena
Published: November 2020

It was found that the addition of polysaccharides of Tussilago farfara L. to chemotherapy scheme “cisplatin + etoposide” lead to more pronounced inhibition of the Lewis lung carcinoma growth in mice due to the reduction of its mass in comparison with these parameters in animals treated according to the same scheme isolated. A use of polysaccharides of Tussilago farfara L. could reduce the hematotoxic effect of polychemotherapy with the “cisplatin + etoposide” scheme, which was expressed in a decrease of leukopenia and anemia.
MENOPAUSAL HORMONOTHERAPY IN ONCOGYNECOLOGIC PATIENTS
Authors: Novikova Olga , Ulrikh Yelena , Nosov V. , Charkhifalakyan A.
Published: November 2020

There is presented the review of domestic and foreign references on the conserved oncological safety of the use of menopausal hormone therapy after treatment for endometrial cancer, cervical cancer, borderline and malignant ovarian tumors, various variants of sarcomas of the uterus, vulva and vaginal cancer. To the opinion of the authors the refusal to prescribe menopausal hormone therapy to patients with oncogynecologic diseases in the anamnesis is usually not justified, the category of patients, to whom hormone replacement therapy is contraindicated, is well described and mentioned in the text. In other cases sex hormones can be used to treat menopausal symptoms and improve the quality of life of patients.
MAMMOGRAPHY AND MAMMOSCINTIGRAPHY WITH 99M TC-MIBI IN THE DIAGNOSIS OF MULTICENTRIC BREAST CANCER
Authors: Chernaya Antonina , Shumakova Tatyana , Busko Yekaterina , Popova Nadezhda , Artemeva Anna , Krivorotko Petr , Krzhivitskiy Pavel , Novikov Sergey , Kanaev Sergey , Bashlyk Viktoriya
Published: November 2020

Objective: To compare diagnostic capability of mammography and mammoscintigraphy with 99mTc-methoxyisobutylisonitrile (MIBI) in diagnostic of multicentric breast cancer. Material and Methods: We respectively analyzed 437 consecutive women with suspected breast cancer between 2014 to 2016. All of them underwent mammography and mammoscintigraphy. Craniocaudal and mediolateral oblique images were obtained. Mammoscintigraphy was performed 15-20 min. after intravenous injection 740 MBq of 99mTc-methoxyisobutylisonitrile (MIBI). Final interpretation of the data was done according to histological examination. Results: Breast cancer was detect in 367(84%) of patients. Most of them 320(87%) had single node breast cancer and 47(13%) - multicentric breast cancer. Sensitivity, specificity and accuracy in diagnostic of multicentric breast cancer were 40,4%, 95,3%, 88% for mammography and 83%, 98%, 96% for mammoscintigraphy respectively. The combination of these methods allowed significantly increase sensitivity of breast cancer detection up to 93,6%. Specificity was 93,4%.
EFFECTIVENESS OF ENDOBRONCHIAL PHOTODYNAMIC THERAPY IN COMBINATION WITH CHEMOTHERAPY IN NON-SMALL CELL LUNG CANCER
Authors: Akopov Andrey , Rusanov Anatoliy , Urtenova Margarita , Kazakov Nikita , Cheremnykh A. , Chistyakov I. , Gerasin A. , Romanikhin A.
Published: November 2020

Aim. To evaluate safety and effectiveness of combined treatment of non-small cell lung cancer (NSCLC) including chemotherapy and endobronchial PDT.
Methods. Results of treatment for two groups of patients with central advanced NSCLC were compared, 75 patients in each. In arm A first line chemotherapy with endobronchial photodynamic therapy (PDT) was done, in arm B - chemotherapy only. PDT was performed with the use of chlorine based photosensitizers in the dose of 1 mg/kg body weight.
Results. Investigated groups were comparable. No serious PDT complications were observed. The number of patients progression (p=0,05) was significantly different in favour of arm A. Remission in arm A was noted in 90% of patients, in arm B - in 76% (p=0,02). One-year survival was 60% and 41% for groups A and B, respectively (р=0,03).
Conclusion. Combination of endobronchial PDT and chemotherapy is safe and effective, makes possible to improve results of treatment and survival in central advanced NSCLC.
INFLUENCE OF CLINICAL CHARACTERISTICS AND VOLUME OF CYTOREDUCTION IN PATIENTS WITH PRIMARY GLIOBLASTOMA ON OVERALL SURVIVAL
Authors: Matsko Marina , Matsko Dmitriy , Volkov Nikita , Ulitin Aleksey , Ievleva Aglaya
Published: November 2020

Patients with glioblastoma (GB) rarely survive more than 3 years. This study aimed to analyze clinical characteristics of long-term GB survivors. 69 patients with primary GB who were treated at the A.L. Polenov Neurosurgical Institute since 2009 and had sufficient follow-up were analyzed; survival of 11 of these patients exceeded 3 years, while the remaining 58 failed to achieve this threshold. An immunohistochemical study was performed using Ki-67 and GFAP antibodies. Patients were divided into two groups: the first included 11 patients with a survival rate of more than 3 years, the second (comparison group) with a survival rate of less than 3 years included 58 patients. Long-term survival correlated with the younger patients age (p = 0.002) and tumor response to temozolomide (p = 0.004). Other clinical features, including gender (p = 0.484), Karnovsky status (p = 0.322); tumor location (p = 0.078), volume of the lesion and the number of affected lobes (p = 0.132), the number of surgical interventions (p = 0.278) and the volume of cytoreduction (p = 0.105) were not prognostic in this small patient cohort.
ANALYSIS OF CLASSIFICATIONS AND ALGORITHMS OF SURGICAL TREATMENT FOR SPINAL TUMORS, MODERN APPROACH IN PLANNING
Authors: Ptashnikov Dmitriy , Magomedov Shamil , Rominskiy Sergey , Tatarintsev A.
Published: November 2020

There are collected and analyzed recognized and claimed in the work scales and algorithms used to evaluate the prognosis and condition of cancer patients with metastatic spine damage. An attempt was made to generalize and combine multidisciplinary approaches to improve prognosis in treatment of patients of this category.
SURGICAL TREATMENT OF PATIENTS WITH CANCER OF THE VULVA
Authors: Zharov Aleksandr , Kravchenko Galina , Saevets Valeriya , Vazhenin Ilya , Mukhin A. , Chernova L. , Gubaydullina T. , Taratonov A.
Published: November 2020

The article presents historical aspect of radical surgical treatment of patients with cancer of the vulva from the beginning of the XX century to nowadays. Article presents positive and negative aspects of different surgical techniques in reconstructive plastic component and lymph circulation paths. Question about conducting the inguinal-femoral lymphadenec-tomy always evoked mixed controversial disputes various authors, which leads to index decline or rejection of this type of operation.
STUDY OF RETINOBLASTOMA PENETRANCE AND PHENOTYPE
Authors: Kazubskaya Tatyana , Alekseeva Yekaterina , Ushakova Tatyana , Yarovaya Vera , Trofimov Yevgeniy , Mikhaylova Svetlana , Lyubchenko Lyudmila , Kozlova V. , Strelnikova V.
Published: November 2020

In this study we characterized hereditary forms of retinoblastoma (RB). Mutational analysis was conducted among 85 RB patients and 156 their relatives. Using a combination of NGS (next generation sequencing) and MLPA (Multiplex Ligation-dependent Probe Amplification) assays we found RB1 germinal mutations in majority of RB patients (96,4% - 27/28) with binocular disease and in 21% (12/57) with monocular RB.A relationship between different types of RB1 germline mutations and clinical manifestation was analyzed. Mainly., hereditary RB developed into severe binocular clinical form with high penetrance. However in some families low penetrance was observed (when patients carrying germline mutation didn’t develop RB). We confirmed that 3 mutations at splice sites: с.607 + 1G>T (intron 6); c.1422-8delT (exon 16); g.61807 G>A (exon 9); and 2 missense mutations: p. 1364 G>C (14 exon); с.1981 C>T (20 exon) were inherited from not affected fathers. These RB cases were less severe (unilateral RB developed later in life). Of the 85 tested RB patients, germline mutations were detected in 45.8% (39/85), 41% (16/39) among which were localized in exons 12-18, 19-23. Hence, different RB mutations were associated with various phenotype. We suggest conducting genetic testing among all RB patients. This will allow identification of asymptomatic carriers with low penetrance mutations, germline mosaicism, lead to early diagnosis, facilitate development of individual treatment plans and determine genetic risk among affected families.
PRIMARY MELANOMA OF THE GALLBLADDER MANIFESTED BY ACUTE CHOLECYSTITIS. DESCRIPTION OF A SINGLE CASE
Authors: Kit Oleg , Kolesnikov Yevgeniy , Myagkov Roman , Kharin Leonid , Nepomnyashchaya Yevgeniya
Published: November 2020

Most of melanomas of the gallbladder are metastatic lesions of cutaneous melanoma. Primary melanomas of the gallbladder are described as single, polypoid, intraluminal masses emanating from the mucous membrane. The most important characteristic is the absence of melanoma damage to the skin. If it is not possible to localize primary melanoma a multidisciplinary approach to diagnostic search comes to the fore. Predicting for primary melanoma of the gallbladder is a difficult task due to the small number of cases and the absence of long-term follow-up for this category of patients.
RADIATION BOOST AFTER WHOLE-BREAST IRRADIATION: DOSIMETRIC COMPARISON OF HIGH DOSE RATE INTERSTITIAL BRACHYTHERAPY AND IRRADIATION WITH ELECTRONS
Authors: Kanaev Sergey , Bykova Ye. , Akulova I. , Popova Nadezhda , Krzhivitskiy Pavel , Krivorotko Petr , Ponomareva Olga , Bryantseva Zhanna , Novikov Sergey , Melnik Yu.
Published: November 2020

Purpose: dosimetric comparison of high dose rate interstitial brachytherapy (HDR) and irradiation with electrons for radiation boost after whole-breast irradiation.
Material and methods: in 62 patients with рТ1N0М0-рТ2№М0 breast cancer we used HDR brachytherapy for delivering boost to tumor bed. In all cases insertion of plastic needles was performed under CT control with subsequent 3D planning. Pre-insertion CT were used for 3D planning of boost delivery with electrons.
Results: Boost delivery with HDR brachytherapy had several important advantages when compared with boost with electrons. HDR brachytherapy demonstrated more accurate irradiation of tumor bed: D90 HDR - 93,1 % (69,1 % - 118 %), D90 electrons - 86,2 % (47,6 % - 104,1 %). Boost delivery with HDR brachytherapy help to minimize radiation burden to left main coronary artery - Dmax electrons - 14.8 % (0.2 %-71.8%), Dmax HDR - 5.2 % (0.7 %-14.2 %). Radiation burden to left anterior descending artery is also decreasing: Dmax electrons - 21.9 % (0.8 %-94.1 %), Dmax HDR - 10.5 % (1.9 %-31.5 %). Radiation dose absorbed in ip-silateral lung also significantly lower with HDR brachytherapy: Dmed electrons - 6,5 % (0,5 % - 19,3 %), Dmed HDR - 2,3 % (0,8 % - 10,8 %).
Conclusions: the present dosimetric analysis indicated that boost delivery with HDR brachytherapy is more accurate than irradiation with electrons.