bluuebunny/crossref_metadata_2025 huggingface dataset:
The Influence of Doi Moi on the Internal Security of Vietnam in the 21st Century
Authors:   Adam Mickiewicz University in Poznań (Poland), Kościelniak Karol
Published: October 2019

The Socialist Republic of Vietnam, just like other countries, functions in determined conditions which influence the way of determining and understanding the security and shaping of the security policy. There prevails a division to problems of an internal and external nature. While talking about and indicating global problems which in consequence can influence the internal security of a country, challenges and threats that countries face need to be noticed. These are ecological, demographic, political, economic and social threats. While looking at factors determining the internal security of a country, special attention needs to be paid to the state of relations and its surroundings, a state of system stability, a level of social peace, a level of public safety and a level of public order.
Book Review: Karolina J. Helnarska, Cultural factor in French Foreign Affairs, Adam Marszałek Publishing House, Toruń 2013, p. 410
Authors:   Lazarski University in Warsaw (Poland), M. Fiszer Józef
Published: October 2019

France with its turbulent history, of foreign affairs and rich culture, has over the centuries been a fascinating topic of academic research for historians, political scientists, lawyers, sociologists, culture experts and publicists. And no wonder, since this country – as a continental superpower – was always conducting its politicson a global scale and was – still is – an important player in the international arena. From medieval times, the 17th century especially, France has been considered an important centre of European and world culture, even of civilisation in general, who’s status and role grew stronger in the Napoleonic era, when the French language became the language of diplomacy and politics, the language of people of science and culture. Culture, its rich content and spiritual values quickly became a part of France’s foreign policy.
Book Review: M. Chmaj, W. Skrzydło, System wyborczy w Rzeczypospolitej Polskiej [The Election System in the Republic of Poland], Wolters Kluwer Polska – LEX, Warsaw 2011, pp. 182
Authors:   Nicolaus Copernicus University in Toruń (Poland), Marszałek–Kawa Joanna
Published: October 2019

In 2011, the long-awaited fourth issue of the book System wyborczy w Rzeczypospolitej Polskiej was published by the Lex publishing house. The issue includes the codification of election law, which was enacted in 2011.The authors of the presented issue are two outstanding Polish constitutionalists.
Book Review: The Civil Bill on Chambers of Commerce and Industry in Poland, ed. Stanisław Wykrętowicz, Scientific Publishing WNPiD UAM, Poznań 2012, pp. 164
Authors:   University of Gdańsk (Poland), Słobodzian Beata
Published: October 2019

Publication on the topic of the economic self-government regime in Poland deserve special cognitive attention. The book The Civil bill on Chambers of Commerce and Industry in Poland, edited by Stanisław Wykrętowicz – expert and researcher of these issues – is the result of years of research conducted by research centres (Adam Mickiewicz University in Poznań, Wrocław University of Economics, Nicolaus Copernicus University in Toruń, University of Gdańsk) and cooperation between circles of researchers and the representatives of chambers of commerce and local government practices.
Citizenship, Migration, and the Nation–State: Exploring UK Policy Responses to Romanian and Bulgarian Migration
Authors:   Queen's University (Canada), Yang Jenny
Published: October 2019

Questions of citizenship and nationhood have increasingly gained prominence given the internationalisation of employment, especially with respect to the free movement of workers within the EU. Scholar Rogers Brubaker has suggested that an absence of a strong identity as a nationstate and the lack of an established national citizenship have contributed to “the confused and bitter politics of immigration and citizenship during the last quarter-century” in Britain. This legacy continues to this day. For instance, on the fi rst of January 2014, migration and employment restrictions on Romanians and Bulgarians were lift ed, provoking mass public outcry in the UK. In a recent poll, three quarters of respondents expressed concern about the possible infl ux of Romanians and Bulgarian migrants. Playing on populist fears, London mayor Boris Johnson quipped: “We can do nothing to stop the entire population of Transylvania – charming though most of them may be – from trying to pitch camp at Marble Arch”. British ministers have even considered launching a negative publicity campaign in Bulgaria and Romania to dissuade migrants, highlighting the dreary weather and lack of job opportunities in Britain.
A Borderland and the Local Authority
Authors:   University of Opole (Poland), Wroniszewska Bożena , Ganowicz Ewa ,   University of Opole (Poland)
Published: October 2019

In the era of globalization, unifi cation and the disappearance of borders, paradoxically, increasingly important is their determination, stressing the diversity, regionalization eff orts to achieve autonomy. Th is is evident in the ongoing scientific discussion at the junction of many areas where there is the issue of the border is quite clearly marked. Th ese considerations place them in the context of politics, and therefore power, but located locally. This authority, its scope, instruments are determined by the nature of the border, which is analyzed in relation to the center. Th us, they are seen as places where all processes are either specific or autonomous in relation to those occurring in the centers, or (as they are parts of a greater whole) underlying causes of phenomena are searched beyond their borders1. In literature, the frontier is treated not as the periphery, located far away from the border territories, but diff erent in many ways, integral components of an organization, equipped with a certain degree of independence regarding the implementation of their own needs.
The Europeanization of the Polish Safety Policy in the Context of its Participation in National Armed Military Forces Missions in the European Union
Authors:   University of Technology in Poznań (Poland), Hoffmann Tomasz
Published: October 2019

For some time now, an issue of the Europeanization has been quite deeply explored in literature on political science. Numerous authors take on that subject in a variety of contexts, which means that it is a problem that is very interesting from a scientifi c point of view. Th ere are plenty of Polish scientists researching this area, as well as a great number of foreign publications. An interest of Europeanization’s processes is most often investigated in the context of public politics. In this article, by the use of a nomological – deductive approach, the author endeavors to make an explanation of the term Europeanization and also to show to what extend and how the Europeanization of Polish armed forces succeeded in the context of their participation in missions lead by the European Union.
The U.S. Secret Service History, Mission and Role in the Homeland Security Strategy
Authors:   University of Humanities and Sciences in Kielce (Poland), Wiśniewska Magdalena
Published: October 2019

The United States Secret Service is an American federal law enforcement agency that is part of the U.S. Department of Homeland Security. Until March 1, 2003, the Secret Service was part of the U.S. Department of the Treasury. The Secret Service has two distinct areas of responsibility: Financial Crimes, covering missions such as prevention and investigation of counterfeiting of U.S. currency and U.S. treasury securities, and investigation of major fraud; Protection, which entails ensuring the safety of current and former national leaders and their families, such as the President, former presidents, vice presidents, presidential candidates, visiting heads of state and foreign embassies. Protecting national leaders, visiting heads of state and government, designated sites and National Special Security Events has become more complex with the evolution of conventional and non-conventional weapons and technology. In meeting new challenges, the Secret Service will continue to provide progressive training, devise and implement sound security plans, measures, equipment and systems to ensure the safety of individuals, sites and events under Secret Service protection. Th e Secret Service’s unique investigative and protective mission is sustained by a strong, multi-tiered infrastructure of science, technology and information systems; administrative, professional and technical expertise; and management systems and processes.
Research Methods in Safety and Defence Studies, a Pragmatic Approach
Authors:   University of Technology in Poznań (Poland), Hoffmann Tomasz , Hoffmann Joanna ,   University of Technology in Poznań (Poland)
Published: October 2019

Safety and defence studies have a very short history, as they were created quite recently. Hence the possible assumption that research methods that are used in them are in a sowing stage. In spite of it, there are researchers that decided to undertake a variety of explorative challenges and they try to use different research method, very often choosing them in reference to investigated reality. Therefore, it can be assumed that the methodology of safety and defence studies has not completely developed (yet). Borrowing methods from different sciences is a very difficult venture which causes situations when research results are false or they do not support any of the stated hypotheses. In the objective article, a review of research methods used for now in safety studies has been made. Of course, it can not be suggested that they are the only and the best ones. Actually, scarcely the quantity of conducted researches and investigated issues can let researchers make an observation which method is a leading one. For now, researchers try to look for accurate solutions for them and the investigated matter at the same time. It is very similar to a promotional work (such as essays, researches). In universities, where degree dissertations and Masters’ theses are being created, different research methods are used to apply to them. It happens quite often that the used methodology derives from pedagogical sciences. Some of the universities use research methods borrowed from political sciences. Another ones use methods that are quite sophisticated and very often draw from a variety of scientific disciplines. To recapitulate, one can hope that it is only the matter of time until together with maturating of the new discipline which is safety and defence studies, some methodological patterns will also be created.
Expansive Conflict
Authors:   Maria Curie–Skłodowska University in Lublin (Poland), Litwin–Lewandowska Dorota
Published: October 2019

The paper discusses the problem of difficult conflicts, whose dynamics is characterised by intensifi cation of factors influencing the course of a conflict, and conflicts which are considerably difficult to resolve. Among many conflicts of high intensity and escalation it is legitimate to identify a specific group of conflicts which can be viewed in a special way due to their parameters. The author of the paper suggests that they should be distinguished and regarded as a specific type of conflict called an expansive conflict. Expansive means expanding in size or scope, aiming at extension of influence or power, or in another sense: insistent and intemperate in expression of feelings, quick-tempered, effusive. Expansiveness means striving for enhancement of one’s impact, impulsiveness and effusiveness, as well as a kind of possessiveness manifested in extending one’s influence to more and more new areas. Therefore, asking about expansiveness, we pose questions: why – who – where – how strong – how fast. Th ese are the questions about the origin, parties to the confl ict, its place, force and rate of spreading. This uncomplicated model can be used to describe a conflict. The introduction of the notion of an expansive conflict can be justified and applied in practice for conflict processes of the extraordinary course, especially in relation to macro conflicts originating in the sphere of politics (superpower policy versus democratisation), economy (corporations) or culture (expansion of mass culture).
The Influence of the Common Agricultural Policy and EU Funds on Rural Development after the Accession of Poland to the European Union
Authors:   University of Szczecin (Poland), Rdzanek Dorota
Published: October 2019

The basic function of agricultural areas is, according to the European Charter for Rural Areas, agriculture and preservation of the natural environment based on a well-functioning agricultural sector that operates in harmony with nature. The Council Regulation (EC) 1257/1999 on support for rural development from the European Agricultural Guidance and Guarantee was adopted in 1999. The programmes that are currently binding in the territory of Poland were developed in accordance with the EU policy expressed in the abovementioned acts and other documents concerning development of rural areas. These included: the Rural Development Programme that focused on social and environmental aspects, as well as a part of the Sectoral Operational Programme devoted to the development of rural areas, as well as restructuring and modernisation of the food sector. Based on the priorities of the Council regulation, two strategic objectives have been set: 1) Improvement of competitiveness of the agriculture and food economy, 2) Sustainable development of rural areas. Implementation of these objectives requires the support of the Common Agricultural Policy. Polish European Union membership contributed to setting its objectives and increasing the ability to subsidise economic entities, as well as develop both the food and rural areas economy.
“The Property Has Been Fiercely Divided” between the Authorities in Russia and the Capital Is a “Tasty Morsel” for the People Who Govern it – the current economic situation in Moscow
Authors:   Nicolaus Copernicus University in Toruń (Poland), Gburzyńska Natalia
Published: October 2019

This article refers to the contemporary situation in the Russian economy and in the Russian capital economy. Economy in Russia is based on the extraction of raw materials. However, in 2010 economic forecasts for the country were optimistic. In this period economic development was strong and the country became a member of the BRICS group. One of the issues of the Russian Federation economy was the backing of the old system. Most investments were focused on the energy sector when in the public sector the changes were smaller. To increase revenues and funds big reforms are necessary and new investments. One possibility to improve the economic situation is to focus on greater extraction of raw materials. Another option is to resign from a monocultural economy. The situation in Moscow is better than the general economic situation in the Russian Federation. GDP increased regularly. In 2008 Russia took 15th place in the ranking of the hundred largest cities GDP. Th e Moscow economy is based especially on the trade of energy resources. Moreover, profi t is gained from business activities and industry. The level of unemployment in Moscow is the lowest in comparison to all regions. In the capital city it fluctuates between 0,5% and 1%. A major problem in the capital city is the constant immigration from other part of the Federation and other foreign countries. In majority, people who come to Moscow are the job seekers. Also the signifi cant problem is ubiquitous corruption.
Report on the Scientific Conference Świnoujście LNG Terminal and the energy security of the region and Poland, Szczecin, 13–14 November 2013
Authors:   University of Szczecin (Poland), Czapiewski Tomek
Published: October 2019

The Scientific Conference under the name “Świnoujście LNG Terminal and the energy security of the region and Poland” was held at the Institute of Political and European Studies in Szczecin on 13th-14th November 2013. The Conference was attended by many eminent scientists and practitioners from all over Poland. Employees of inter alia AGH University of Science and Technology, Warsaw University, Jagiellonian University, Graduate School of Humanities and Journalism, Adam Mickiewicz University in Poznan, Western Institute and University of Wroclaw were present. Lack of experience in the execution of such investments in Poland and lack of national legislation adapted to the task required preparation and introduction of new laws and organizational solutions. Adopting the relevant legislation was treated as a priority by the Polish government and it helped to improve energy security and intensify the development of the Polish gas market. The location of the Świnoujście Terminal LNG in the Baltic Sea will provide the possibility of importing LNG from anywhere in the world and the distribution to operators in the country. The adoption of such solutions will be a viable diversifi cation of gas resources. This is important from the point of view of strategic Polish interests.
Seminar Legislative experiences of Poland and Kazakhstan in the scope of the territorial self-government and national minority policy, Warsaw, Senate of the Republic of Poland, 9 July 2014
Authors:   Katowice School of Economics (Poland), Bisztyga Andrzej
Published: October 2019

The seminary was a joint undertaking of the two committees of the Senate of the Republic of Poland and the Embassy of the Republic of Kazakhstan in Warsaw. It was held by the Senate Legislation Committee, Senate Territorial Self-Government and State Administration Committee and a team of the Embassy of Kazakhstan led by Ambassador Dr Yerik Utembaev. The seminary’s guests were Members of the Mazylis, Kazakhstan’s lower chamber of parliament chaired by Mazylis Deputy Chair – Mr Sergey A. Dyachenko. Besides, the seminary was participated by deputies, senators as well as representatives of business, academic and political communities, interested in and taking action for the development of the relations between Poland and post-Soviet states of Central Asia, including President of Adam Marszałek Publishing House, Dr Adam Marszałek, Doctor of Honoris Causa, Kyrgyz Russian Slavic University in in Bishkek, Kyrgyzstan. The organization of the seminary had several aims. The main aim of the event was the exchange of experiences between Poland and Kazakhstan in the scope of legislation concerning the activity of both countries’ territorial self-governments as well as in the scope of safeguarding freedoms and rights of national minorities. Of no less importance was enabling the Polish participants to learn the specific characteristics of the functioning of Kazak administration, which comes to pursue its tasks within a very extensive area inhabited by approximately 140 nations.
Book Review: Anna Potyrała, Unia Europejska wobec międzynarodowych sądów karnych. Geneza, istota i praktyka współpracy [European Union towards international criminal courts. Origins, nature and practice of cooperation], Wydawnictwo Naukowe WNPiD
Authors:   Adam Mickiewicz University in Poznań (Poland), Malendowski Włodzimierz
Published: October 2019

‘The EU towards international criminal tribunals. Genesis, Concept and Practice of Cooperation’ is a study that focuses on the important research question of the broad and multi-aspectual problem of criminal tribunals on the international arena. This has been tackled in many Polish and foreign publications, however, to date no work has studied the EU cooperation with the three international criminal tribunals – two ad hoc ones and a permanent one. Therefore, it is necessary to recognise the ambitious and pioneering task and venture that the chosen research field is highly appropriate not only if one casts an eye at the monograph title, but foremost the case put forward in the introductory part.
Book Review: Łukasz Zaborowski, Podział kraju na województwa. Próba obiektywizacji [Division of Poland into Voivodeships. An attempt at Objectivisation], Wydawnictwo Naukowe Scholar, Warsaw 2013, pp. 164
Authors:   University of Gdańsk (Poland), Słobodzian Beata
Published: October 2019

Issues related to the administrative division of Poland are among those problems that are intriguing to various social circles: researchers, scientists, economists, politicians. Disputes as to the number of voivodeships and their shape have been going on uninterruptedly since the introduction of the new administrative division of Poland in 1999. Every now and then we are faced with recurring debates, disputes about the need to introduce changes in Poland’s territorial organisation, yet with no effects. That is why issuing the publication “Division of Poland into Voivodeships. An attempt at Objectivisation” in 2013 seems justified and necessary. This study might spur deliberations on the reorganisation of territorial space on a voivodeship level.
Otfried Höffe’s Theory of Social Justice
Authors:   National Academy of Sciences of Ukraine (Ukraine), Sytnichenko Liudmyla
Published: October 2019

The problem of justice, one of the key problems of contemporary political philosophy, is reconsidered in the light of a new paradigm: Otfried Höffe’s theory of transcendental exchange. The main research question is how this theory influences our understanding of the ways of formation of just moral and legal grounds in contemporary society. In order to understand justice adequately, it is important to regard it as personal responsibility, deeply related to attitudes of solidarity and recognition. There is an attempt to fuse moral and material grounds of social existence in order to overcome social injustice. Freedom and justice are rooted in the living world and are based on formal norms and procedures of morality and law. This gives us methodological grounds for understanding Höffe’s philosophy of political justice, which regards freedom and justice as the main conditions of human existence.
Experience of European Integration in the Former Soviet Union: Political and Legal Aspects
Authors:   Al–Farabi Kazakh National University (Kazakhstan), L. Baideldynov Daulet
Published: October 2019

The article is devoted to the political and legal analysis of integration processes in the post-Soviet states – Russia, Kazakhstan and Belarus. It reviews the activities of the Customs Union and its economic and political expediency, as well as the creation and functioning of the Eurasian Economic Union. The author has revealed the reasons for the ineffectiveness of the EAEC activities and proposed a number of legal, political and economic measures to improve it. The paper provides examples of internal economic and political contradictions of the Eurasian Economic Union and offers a legal mechanism to resolve them, and further regulation on the basis of creating a single legal space.
Relations between the Europeanization and a Development of Public Policy on the Example of Cohesion Policy
Authors:   Koszalin University of Technology (Poland), Hoffmann Tomasz
Published: October 2019

The article presents basic relations which happen among Europeanization and the public politics on the example of the politics of the cohesion. The author makes the broad exploration objective concepts and also postulates determined conclusions and recommendations.
Individual Differences and Attitudes towards the Government’s Remembrance Policy
Authors:   Nicolaus Copernicus University in Toruń (Poland) & University of Rostock (Germany), Schattkowsky Ralph , Czarnek Gabriela ,   Jagiellonian University in Kraków (Poland), A. Muszyński Marek ,   Jagiellonian University in Kraków (Poland) & Educational Research Institute in Warsaw (Poland), Wawrzyński Patryk ,   Nicolaus Copernicus University in Toruń (Poland)
Published: October 2019

The paper presents results of the experimental study on the government's remembrance policy, attitudes towards it, and the influence of remembrance narratives. It discusses individual differences of participants on three different grounds: (1) interest in history or politics, and level of historical knowledge, (2) features of cognitive motivation measured by the need for closure questionnaire: preference of order, desire for predictability, discomfort with ambiguity, closed-mindedness and decisiveness, and (3) response to the presented narrative, including inspired emotions and an assessment of a story. Collected data and research observations offer an interesting and valuable insight into relationships between various factors and citizen's support for the remembrance policy. They also lead the team to formulate three conclusions which may be used to develop theoretical understandings of this aspect of politics within political science and related disciplines.
The Process of Social Reintegration of Convicts on the Background of World Penitentiary System. The Analytical and Synthetic Outline of the Issue
Authors:   School of National Economy in Kutno (Poland), Pierzchała Kazimierz
Published: October 2019

The following text shortly outlines some basics terms and difficulties connected with social rehabilitation term of some people who had a staying in the prison; beginning from the short explanation of the term, through highlighting the characteristic of reintegration process, to main problems which a person has when comes back to the society and also some
Legal and Political Determinants of Implementation of the Principle of Subsidiarity in the Federal Republic of Germany
Authors:   University of Opole (Poland), Wroniszewska Bożena
Published: October 2019

It is not surprising that subsidiarity is very often discussed with autonomy and federation (equally multidimensional concepts, similarly discussed in science). It is clearly evident taking into account, for example, results of analysis of the key words (tags) in scientific publications. The European Union has significantly contributed in popularizing of the concept so it is no surprise that strongly linked with EU's problems has become a central point of the discussion of its organizational structure and internal relationships between forming elements. It is difficult to imagine analysis of the conditions for implementing of subsidiarity in Germany without prior presentation of the state political system's solutions. Studying the structure and functioning of public administration enables to identify the place and role of the local government, to measure degree of independence of the local authority as a central point of discussion in relation to the subsidiarity.
LNG Terminal in Świnoujście as an Element of Poland’s Energy Security
Authors:   University of Szczecin (Poland), Kamola–Cieślik Małgorzata
Published: October 2019

Based on analysis of the research material shown Council of Ministers actions for the implementation of the project for the construction of the LNG terminal. The purpose of the article was to obtain answers to the following research questions: What are the reasons of delaying the opening of the LNG terminal in Świnoujście? In what extent the activities of the gas terminal in Świnoujście enhance the Polish energy security? After the analysis, it was found that there are several reasons for not giving to use LNG terminal in Świnoujście. One of them was and is the lack of involvement of the Polish government in this investment. Poland is still dependent on Russian natural gas. Activity of LNG terminal in Świnoujście would increase gas safety of Poland and limit its dependence on the Russian Federation.
Report on the 2nd Asian Congress
Authors:   University of Gdańsk (Poland), Bielawski Kornel
Published: October 2019

II Asian Congress took place on 21st and 22nd of May, 2015. It was the largest event of its kind in Europe. Once again, it was a great opportunity to meet representatives of science, business and politics who deal with Asian affairs daily. The event appeared to be so spectacular that it was impossible to organize it in one place. Therefore, many panels were held simultaneously in the Kuiavian-Pomeranian Voivodeship Marshall’s Office building, Torun City Council’s building and the Modern Art Centre „Signs of Time”. The event management of this magnitude would not be possible if not for the professional and efficient coordination led by Professor Joanna Marszałek-Kawa and a number of cooperating institutions, such as Asia-Pacific Society, KuiavianPomeranian Voivodeship Marshall’s Office, Torun City Council, and Professor Czesław Mojsiewicz Fund for International Cooperation Support, Eastern Studies Center, Political Science and International Studies Division of NCU.
Polish–Kazakh Seminar, Warsaw, Senate of the Republic of Poland
Authors:   University of Zielona Góra (Poland), Bisztyga Andrzej
Published: October 2019

The Senate of the Republic of Poland hosted another seminar in a series of Polish-Kazakh seminars. These seminars are an effect of the cooperation of Polish Senate, including the Senate Legislative Committee run by Senator Doctor Piotr Zientarski and the Embassy of the Republic of Kazakhstan in Poland headed by Ambassador Yerik Utembayev. These seminars serve the purpose of mutual closing and getting to know of the representatives of both countries’ parliamentary, scientific and cultural environments. The leading subjects of the June seminar were the issues of deportation of Polish people to Kazakhstan under Stalin rule and the relations of the Kazakh state with European countries – especially with Poland – in Middle Ages. In the seminar participated among others Vice Director of the Eastern Department Ministry of Foreign Affairs Mr Zdzisław Raczyński, Head for the Senate Legislative Committee and Deputy Head for Kazakh-Polish Parliamentary Group Dr Piotr Zientarski, Ambassador of the Republic of Kazakhstan in Poland Mr Yerik Utembayev, Head for the Department of Legal Systems and Human Rights of Zielona Góra University Faculty of Law and Administration Professor Andrzej Bisztyga, Head for the Department of Public Law, Human Rights and European Law of the University of Social Sciences and Humanities Faculty of Law and Administration and President of the Asia-Pacific Society Doctor Adam Marszałek. The active participants of the seminar were Doctor Władysław Sokołowski, former Ambassador of the Republic of Poland in Kazakhstan and Professor Andrzej Wierzbicki of Warsaw University. The seminar was attended by numerous Members of Parliament and representatives of various academic centres.
The Determinants of Electoral Volatility
Authors:   Silesian University in Katowice (Poland), Stelmach Katarzyna
Published: October 2019

The last presidential elections gave rise numerous questions and doubts – particularly in the scientific and media environments – regarding the conditions for electoral behaviours in Poles, as signalled by the results achieved by particular candidates. The media discourse abounded in more or less definite statements regarding voter turnout data for particular population groups, the destabilization of the electorate’s political preferences and the phenomenon of the transfer of votes in between the supporters of particular candidates, both in the historical approach and in the course of the election campaign. The intensity and temperature of these discussions were indicative of the fact how poorly this area is penetrated empirically
The European Medicines Agency Review of Kymriah (Tisagenlecleucel) for the Treatment of Acute Lymphoblastic Leukemia and Diffuse Large B-Cell Lymphoma
Authors: Ali Sahra , Kjeken Rune , Niederlaender Christiane , Markey Greg , Saunders Therese S. , Opsata Mona , Moltu Kristine , Bremnes Bjørn , Grønevik Eirik , Muusse Martine , Håkonsen Gro D. , Skibeli Venke , Kalland Maria Elisabeth , Wang Ingrid , Buajordet Ingebjørg , Urbaniak Ania , Johnston John , Rantell Khadija , Kerwash Essam , Schuessler-Lenz Martina , Salmonson Tomas , Bergh Jonas , Gisselbrecht Christian , Tzogani Kyriaki , Papadouli Irene , Pignatti Francesco
Published: October 2019

Chimeric antigen receptor (CAR)–engineered T-cell therapy is becoming one of the most promising approaches in the treatment of cancer. On June 28, 2018, the Committee for Advanced Therapies (CAT) and the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Kymriah for pediatric and young adult patients up to 25 years of age with B-cell acute lymphoblastic leukemia (ALL) that is refractory, in relapse after transplant, or in second or later relapse and for adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) after two or more lines of systemic therapy. Kymriah became one of the first European Union–approved CAR T therapies. The active substance of Kymriah is tisagenlecleucel, an autologous, immunocellular cancer therapy that involves reprogramming the patient's own T cells to identify and eliminate CD19-expressing cells. This is achieved by addition of a transgene encoding a CAR. The benefit of Kymriah was its ability to achieve remission with a significant duration in patients with ALL and an objective response with a significant duration in patients with DLBCL. The most common hematological toxicity was cytopenia in both patients with ALL and those with DLBCL. Nonhematological side effects in patients with ALL were cytokine release syndrome (CRS), infections, secondary hypogammaglobulinemia due to B-cell aplasia, pyrexia, and decreased appetite. The most common nonhematological side effects in patients with DLBCL were CRS, infections, pyrexia, diarrhea, nausea, hypotension, and fatigue. Kymriah also received an orphan designation on April 29, 2014, following a positive recommendation by the Committee for Orphan Medicinal Products (COMP). Maintenance of the orphan designation was recommended at the time of marketing authorization as the COMP considered the product was of significant benefit for patients with both conditions.
Farklı anaçların ‘Akko XIII’ yenidünya çeşidinde meyve kalitesi üzerine etkileri
Authors: TEPE Seyla , KOYUNCU Mehmet Ali
Published: October 2019

Çalışmada, Serik (Antalya) yöresinde
yenidünya, akdiken ve ayva çöğür anaçları üzerine aşılı ‘Akko XIII’ yenidünya
çeşidinde, anaçların meyve kalitesi üzerine etkilerinin belirlenmesi
amaçlanmıştır. Kullanılan anaçların etkilerini belirlemek için meyve kabuk
rengi, meyve sertliği, meyve ağırlığı, meyve/çekirdek oranı, olgunluk indeksi,
suda çözünebilir kuru madde miktarı, titre edilebilir asitlik, etilen üretimi
ve solunum hızı ölçümleri ile duyusal analiz yapılmıştır. Tesadüf parselleri
deneme desenine göre 3 tekerrürlü olarak yürütülen araştırmadan elde edilen
verilere göre; akdiken anacının meyve ağırlığı ve sertliğini azaltıcı, meyve
çekirdek oranını artırıcı etkisi olduğu belirlenmiştir. Ayva ve yenidünya
anaçlarının bu özellikler üzerinde etkileri akdiken anacına göre daha iyi ve
birbirlerine benzer bulunmuştur. Suda çözünebilir kuru madde miktarı yenidünya
çöğür anacı üzerinde yetişen meyvelerde daha yüksek olurken, titre edilebilir
asit ve olgunluk indeksi akdiken anacı üzerinde yetişen meyvelerde diğerlerine
göre daha düşük olmuştur. Yenidünya anacı üzerinde yetiştirilen meyvelerde
kabuk renginin, akdiken ve ayva anaçları üzerindekilere kıyasla daha canlı
olduğu (yüksek C* değeri) ve sarı ile kırmızı renk tonlarını daha yüksek oranda
(yüksek a* ve b* değeri) içerdiği belirlenmiştir. Sonuç olarak, ayva ve
yenidünya anaçları üzerinde yetişen meyvelerin akdiken üzerinde yetişen
meyvelere göre daha kaliteli ve aromalı olduğu belirlenmiştir.
Araşidonik asidin patlıcan kallus süspansiyon kültüründe fitoaleksin uyartımı üzerine etkisi
Authors: KIRAN Sevinç , ELLİALTIOĞLU Ş.şebnem
Published: October 2019

Bu çalışmanın amacı; Verticillium solgunluğuna dayanımın, bitki dokularında sentezlenen fitoaleksin miktarıyla ilişkisini araştırmaktır. Çalışmada Long Purple patlıcan çeşidi (hastalığa duyarlı) ile S. sisymbriifolium yabani türü (hastalığa dayanıklı) bitkisel materyal olarak kullanılmıştır. Elisitör olarak, araşidonik asit (5 ve 10 mM) çalışmada yer almıştır. Elisitör ile uyarım işlemi 24, 48 ve 72 saat olarak uygulanmıştır. Ekstrakte edilen maddeler gaz likit kromotografisi (GLC) cihazında analiz edilmiştir. Dayanıklı türün kallus süspansiyon kültüründe fitoaleksin oluşumu yeterli düzeyde uyarılamamıştır. Elde edilen bulgular araşidonik asidin kallus süspansiyon kültüründe sadece Long Purple çeşitinde fitoaleksinlerin oluşumunu uyarmada etkili olduğu, in vitro koşularda doku fazında solavetivon ve süzüntü fazında ise lubimin maddelerinin biriktiği belirlenmiştir. En yüksek madde birikimleri her iki fazda ‘10 mM araşidonik asit x 72 saat uyarı süresi’ kombinasyonunda elde edilmiş, ‘doz x uygulama süresi’ etkileşimi önemli bulunmuştur.
Real-time Historical Estimates of the Output Gap
Authors: Van Cleve Luke , Laforte Jean-Philippe , Stella Andrea
Published: October 2019

The purpose of this note is to highlight the recent availability of an expanded set of historical data of the staff's estimates of the real-time output gap at the Real-Time Data Research Center of the Federal Reserve Bank of Philadelphia.
Igualdad de oportunidades en los procesos electorales y la regulación del gasto electoral. Examen de la ley n° 19.884 sobre transparencia, límite y control del gasto electoral
Authors: Cépeda Gladys Camacho
Published: October 2019

El presente trabajo analiza el marco jurídico institucional del financiamiento de las campañas electorales regidas por la Ley Sobre Transparencia, Límite y Control del Gasto Electoral Nº 19.884. Con tal fin, examina los tipos de financiamiento, las atribuciones y mecanismos de control que el Servicio Electoral (SERVEL) puede ejercer para asegurar el cumplimiento de las normas del gasto electoral junto a las garantías institucionales que se reconocen al órgano fiscalizador y las condiciones que inciden tanto en la imparcialidad como en la eficiencia del control. Finalmente, el trabajo describe el proceso general del control de ingresos y gastos electorales que establece la norma legal en lo que respecta a fiscalización, rendición de cuentas y el correspondiente sistema sancionatorio
Contribuição para o fomento da radiodifusão pública - uma análise à luz da recente decisão do tribunal constitucional federal alemão
Authors: Fossati Gustavo Schneider
Published: October 2019

RESUMO: O objetivo geral desta pesquisa é avaliar a legitimidade do custeio da intervenção estatal na comunicação social por meio de uma contribuição interventiva. Com relação aos objetivos específicos, a investigação enfrenta a constitucionalidade da Contribuição para o Fomento da Radiodifusão Pública no Brasil, motivada pelo ainda recente julgamento da correspondente contribuição na Alemanha, pela Corte Constitucional deste País. Para tanto, são avaliados criteriosamente os requisitos de validade das contribuições interventivas, fazendo-se um alerta sobre os riscos da sua indistinta utilização. Propõe-se enfrentar os problemas relativos aos requisitos de validade das contribuições, à possibilidade de as contribuições interventivas serem cobradas indistintamente, como se fossem impostos, à referibilidade como requisito de validade das contribuições interventivas, à possibilidade de se encontrar um equilíbrio entre as exigências formais da praticabilidade e a rígida tipologia das espécies tributárias, à forma mais adequada de se realizar o custeio da intervenção do Estado na comunicação social e à forma como a decisão da Corte Constitucional alemã pode contribuir para o debate da contribuição no Brasil, inclusive tendo em vista a expectativa de futura manifestação dos tribunais superiores pátrios acerca da sua legitimidade. A pesquisa foi desenvolvida a partir da ainda recente decisão do Tribunal Constitucional alemão e com base na doutrina tributária brasileira e alemã. A análise conclui que a Contribuição para o Fomento da Radiodifusão Pública no Brasil, nos moldes em que hoje se apresenta, é inconstitucional, porquanto a cobrança das empresas privadas de prestação de serviços de telecomunicação e de radiodifusão sonora e de sons e imagens apresenta um evidente problema de referibilidade. A decisão do Tribunal Constitucional Federal alemão sugere para o Direito brasileiro um novo e arrojado formato de cobrança deste tributo, pautado nos ideais de praticabilidade e de eficiência na arrecadação.
Analítica e hermenêutica: duas faces de uma mesma solução para a garantia da racionalidade na aplicação do direito
Authors: Da Silva Willy Potrich , Freire Júnior Américo Bedê
Published: October 2019

O anseio na busca pela racionalidade das decisões judiciais passa, de modo mais profundo, pela busca de sua legitimidade, especialmente em decisões de grande repercussão e relevância, quando os limites de atuação do Poder Judiciário se confunde com os limites estabelecidos para os Poderes Democráticos. Hermenêutica e Analítica, duas formas distintas de se ver o direito, mostram-se também como duas formas distintas de se enxergar a legitimidade da aplicação do direito, na tentativa de desenhar caminhos que permitam algum tipo de controle sobre a subjetividade inerente a qualquer ato volitivo de decidir. No âmbito da justificação das decisões, surgem as teorias da argumentação jurídica, muito bem condensadas na obra de Manuel Atienza, como mecanismo de exteriorização das razões articuladas no campo da consciência. Em face destas, levanta-se a crítica hermenêutica do direito, trazida na obra de Lênio Streck a partir da hermenêutica filosófica de Gadamer, preocupada com a chancela à indeterminação que se pratica ao considerar suficiente um exercício individual de argumentação em detrimento das verdadeiras razões das decisões. As objeções não anulam ou invalidam qualquer das duas formas de se ver o direito, mas certamente as deve forçar a repensar suas deficiências em uma relação complementar mútua. A resposta, na acepção deste trabalho, está em uma base de argumentação dialética, capaz de permitir a melhor depuração das premissas adotadas e, consequentemente, a aproximação do chamado contexto de descoberta.
La prohibición universal de la trata de personas
Authors: Amezúa Luis-Carlos
Published: October 2019

El Derecho internacional prohíbe la trata de seres humanos y la moderna esclavitud, conceptos que incluyen la esclavitud estricta y otras modalidades de explotación como son el trabajo forzoso o la servidumbre, ya sea la servidumbre por deudas o el matrimonio forzoso. Todas estas conductas configuran la definición jurídica de trata de personas. En este artículo mostraremos cómo la situación actual ha hecho necesario expandir el concepto legal de esclavitud para castigar las formas contemporáneas de esclavitud, desarrolladas con la creciente precariedad en el ámbito de la economía globalizada. El TEDH y la CIDH están contribuyendo a configurar esa nueva etapa abolicionista.
Creating Differential Transcript Expression Results with DESeq2 v1
Authors: A Eccles David
Published: October 2019

Differential expression analysis of transcript count tables using DESeq2
Fatty acid extraction and derivatisation v1
Authors: Dusseldorf Igem
Published: October 2019

This protocol enables direct, one-pot fatty acid extraction and derivatisation of plant and bacterial samples for preparation for GC-MS analysis. The protocol was established by the Weber lab for plant seedlings and seeds, but was successfully used for cyanobacteria and E.coli as well.
Phenotypic Characterization of the Working Heart v2
Authors: Dale Abel E.
Published: October 2019

Summary: This protocol describes the procedure used by the DiaComp for cardiac performance, oxygen consumption and substrate metabolic rates in isolated working mouse hearts. Diabetic Complication: References: 1. Belke, D.D., Larsen, T.S., Gibbs, E.M., Severson, D.L. 2001.Glucose metabolism in perfused mouse hearts overexpressing human GLUT-4 glucose transporter. Am J Physiol Endocrinol Metab.280:E420-7. 2. Belke, D.D., Larsen, T.S., Gibbs, E.M., Severson, D.L. 2000.Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice. Am J Physiol Endocrinol Metab.279:E1104-13. 3. Belke, D.D., Larsen, T.S., Lopaschuk, G.D., Severson, D.L. 1999.Glucose and fatty acid metabolism in the isolated working mouse heart. Am J Physiol.277:R1210-7. 4. Larsen, T.S., Belke, D.D., Sas, R., Giles, W.R., Severson, D.L., Lopaschuk, G.D., Tyberg, J.V. 1999.The isolated working mouse heart: methodological considerations. Pflugers Arch.437:979-85. 5. Belke D.D., Betuing S, Tuttle M.J., Graveleau C, Young M.E., Pham M., Zhang D., Cooksey R.C., McClain D.A., Litwin S.E., Taegtmeyer H., Severson D., Kahn C.R., Abel E.D. 2002. Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. J Clin Invest 109:629-639. 6. Mazumder P.K., O’Neill B.T., Roberts M.W., Buchanan J., Yun U.J., Cooksey R.C., Boudina S., Abel E.D. 2004. Impaired Cardiac Efficiency and Increased Fatty Acid Oxidation in Insulin Resistant ob/ob mouse hearts. Diabetes. 53: 2366-2374. 7. Suga H: Ventricular energetics. Physiol Rev 70:247-277, 1990
Production of AAV Virus by Iodixanol Gradient Ultracentrifugation v1
Authors: Institute for Brain Science Allen
Published: October 2019

This protocol is used to produce AAV of any serotype with high purity and high titer.
Protocol of HIV TDR and Subtype test in Beijing v2
Authors: Ye Jingrong
Published: October 2019

We analyzed the demographic, clinical, and virological data of residents newly diagnosed with HIV in Beijing. We did population-based sequencing of the pol gene on plasma specimens and identified drug resistance mutations using the World Health Organization (WHO) list for surveillance of drug resistance mutations. HIV-1 subtype analyses utilized the automated subtyping tool COMET.
OD and GFP Plate Reader Assay (72 h Measurement) v1
Authors: Balletbó Alba
Published: October 2019

Fluorescence measurements of Optical Density (OD) and Green fluorescent protein (GFP) in Escherichia coli.
Cell Counting v1
Authors: Sánchez Laura
Published: October 2019

Bacterial concentration can be measured by several methods. One of them is turbidity. Turbidity, or light scattering, is measured in a spectrophotometer such as a Spectronic 20. This method has the advantage of being the quickest method at the lab bench.
Chitin binding + Bradford assay v1
Authors: Hooftman Robert
Published: October 2019

This protocol can be used to measure the binding capacity of chitin binding proteins and visualizing this using a Bradford assay. The protocol has been adapted from: F. Labroussaa, A. R. Zeilinger, and R. P. P. Almeida, “Blocking the Transmission of a Noncirculative Vector-Borne Plant Pathogenic Bacterium,” Mol. Plant-Microbe Interact., vol. 29, no. 7, pp. 535–544, Jul. 2016.
Nanopore Data Analysis v2
Authors: A Eccles David
Published: October 2019

This is a collection of protocols that I use frequently for the analysis of long read data
Western Analysis used in Oxidative Stress Protocols v2
Authors: Feldman Eva
Published: October 2019

Summary: This is the general protocol used for western analysis of samples from the Oxidative Stress Protocols. There are no specific antibodies described for use, rather a general procedure for creating the western. See the specific assay for the details about the antibodies used. Diabetic Complications:
Removal of gDNA from totalRNA v1
Authors: Dusseldorf Igem
Published: October 2019

Removal of genomic DNA from RNA preparations
Novel Immuno-assay for Detection of Lipophilic Substances v1
Authors: Warkentin Ruben , Doubleday Caitlin
Published: October 2019

Novel Immuno-assay for Detection of Lipophilic Substances Here we provide a methodology for testing antibodies for their binding ability to a lipophilic antigen. This approach was tested using a recombinantly expressed anti-THC-mNG antibody.
Reverse transcription of RNA to cDNA v1
Authors: Dusseldorf Igem
Published: October 2019

Synthesizing cDNA (for qPCR)
Lesion Size v1
Authors: B. Cleo
Published: October 2019

Measuring the lesion size in Brassica oleracea after infection with Xanthomonas campestris pv. campestris.