bluuebunny/crossref_metadata_2025 huggingface dataset:
Examining beverage‐specific trends in youth drinking in Australia before and after the implementation of the alcopops tax
Authors: Mojica‐Perez Yvette , Callinan Sarah , Livingston Michael
Published: January 2020

Introduction and Aims

Alcohol consumption among young Australians has declined markedly since the early 2000s. As yet, there has been no data on how this decline has been spread across different beverages and instead high‐level survey data with significant potential for recall and other bias has been used. Trends in beverage choice among young people following an increase in the ‘alcopops’ tax have also not received much attention.

Design and Methods

Data on ‘yesterday’ drinking occasions were obtained from five waves (2004, 2007, 2010, 2013, 2016) of the National Drug Strategy Household Survey. A total of 23 536 respondents aged 14–29 years were included in this study. Descriptive and regression analyses were conducted to explore trends in alcohol consumption and changes in beverage preferences.

Results

Youth drinking declined by 45% across the study period, with declines of 66% in premix, 48% in spirits, 46% in beer and 33% in wine. Consumption of premix was significantly lower in 2013 and 2016 compared to 2007 amongst the overall sample, males, females, respondents aged 14–21 and 22–29 years, light and heavy drinkers. Significant reductions were also observed in the consumption of premix immediately following the tax (2010) for the younger age group, males and light drinkers.

Discussion and Conclusions

Youth consumption of alcohol has declined during the study period with significant variation across beverage types. We found some evidence of a separate impact for the alcopops tax, although for some groups, declines in premix consumption occurred well after the implementation of the tax.
Global longitudinal strain assessment of the left ventricle by speckle tracking echocardiography detects acute cellular rejection in orthotopic heart transplant recipients: A systematic review and meta‐analysis
Authors: Elkaryoni Ahmed , Altibi Ahmed M. , Khan Muhammad Shahzeb , Okasha Osama , Ellakany Karim , Hassan Adil , Singh Annapoorna , Qarajeh Raed , Mehta Shrushti , Nanda Navin C.
Published: January 2020

Background

In orthotopic heart transplant recipients, surveillance with endomyocardial biopsy is crucial to detect acute cellular rejection (ACR) early. ACR is a common and serious complication of transplantation with substantial morbidity and mortality. Speckle tracking echocardiography with global longitudinal strain (GLS) assessment of the left ventricle has emerged as a possible noninvasive screening modality. We have conducted a systematic literature review and meta‐analysis to evaluate the role of GLS in diagnosing ACR.

Methods

The following databases were queried: PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, and Embase. We compiled all articles evaluating changes in GLS in comparison to endomyocardial biopsy in ACR dated prior to September 2019. Weighted mean differences (WMD) and 95% confidence intervals (CIs) were pooled by using a random effects model. In order to determine the risk of bias, we used the revised version of the Quality Assessment of Diagnostic Accuracy Studies (QUADAS‐2) tool.

Results

Twelve studies met inclusion criteria of which ten were chosen. These studies encompassed 511 patients and 1267 endomyocardial biopsies. There was a significant difference in GLS between patients who did and did not have ACR proven by biopsy (WMD = 2.18; 95% CI: 1.57‐2.78, P = <.001; I2 = 76%). The overall sensitivity for GLS in detecting ACR was 78% (CI: 63%‐90%, P = .123; I2 = 52.2%) while the overall specificity was 68% (CI: 50%‐83%, P = <.001; I2 = 88.3%).

Conclusion

Global longitudinal strain assessment of the left ventricle by speckle tracking echocardiography is useful in detecting ACR and could potentially reduce the burden of frequent endomyocardial biopsies in heart transplant recipients.
Racism, Xenophobia, and Migration in Italy, a Post‐Catholic Country
Authors: Dotti Guido
Published: January 2020

This paper looks at the present situation of xenophobia and racism in Italy through the lenses of land and displacement. It examines the relationship between the homeland and the phenomenon of migration – internal and international – from the beginning of the unitary unified state of Italy (1861) and the Catholic identity of Italian society. Colonialism opened the door to disdain for Black people, while fascism decreed racial laws against Jews without opposition from the Catholic hierarchy. After the Second World War, the Italian Republic banned any form of racism; but more recently the fear of the stranger has led to intolerance of migrants arriving in Italy because of war, violence, hunger, and poverty in their homelands. While Pope Francis, Italian bishops, and many Catholic associations and individuals have called for an attitude toward migrants based on the gospel, sentiments of racism and hate against foreigners are widely present among the population of a formerly Catholic country.
Systemic Evil and Christian Discipleship
Authors: MacDonald Mark
Published: January 2020

Although the churches have focused much of their attention on the individual's encounter with evil, it is urgent and essential that this focus be expanded to consider communal systemic evil. Rediscovering this emphasis in ancient sources – biblical and Indigenous – we begin to see that engagement with systemic evils like racism and colonialism is a central aspect of Christian discipleship. There is a preliminary and important anticipation and realization of this rediscovery in The Arusha Call to Discipleship document of the World Council of Churches. In an age that is beset by the deadly intersection of multiple forms of systemic evil, it is urgent that discipleship confront the principalities and powers that corrupt and destroy life.
Reaching the Champions of Social Justice
Authors: Apawo Phiri Isabel
Published: January 2020

Since the formation of the World Council of Churches (WCC) in 1948, the ecumenical voice against social injustice in the church and society has been strengthening. As one expression of unity among the fellowship, the WCC embarked in 2013 on a Pilgrimage of Justice and Peace to work, pray, and walk together for life‐affirming economies, climate change, nonviolent peace building, and reconciliation and human dignity. Champions of these issues exist within the ecumenical movement. Yet one also finds that champions of one theme are pushing back on another theme. Sometimes it is due to diversity of contexts and biblical and theological interpretations. At other times it is due to unconscious bias about the holistic nature of God's mission of justice for all God's people and creation. This paper grapples with this question: Why are people who are so alive to economic and ecological injustice sometimes blind to racial and gender injustice? To answer this, I explore the existence of conscious and unconscious bias despite the many powerful ecumenical statements that have been issued on racial justice.
Mesenchymal stem cells for treatment of musculoskeletal disease in horses: Relative merits of allogeneic versus autologous stem cells
Authors: Colbath Aimée C. , Dow Steven W. , McIlwraith C. Wayne , Goodrich Laurie R.
Published: January 2020

Mesenchymal stem cells (MSCs) are widely used for treatment of musculoskeletal diseases in horses, but there is ongoing debate regarding the relative safety and efficacy of allogeneic MSCs, compared with autologous equine MSCs. This review summarises the currently available published data regarding the therapeutic use of autologous and allogeneic MSCs in horses. Arguments that have been advanced against the use of allogeneic MSCs include higher risk of immunological reactions and shorter cell survival times following injection. Arguments favouring the use of allogeneic MSCs include the ability to bank cells and reduce the time to treatment, to collect MSCs from younger donor animals and the ability to manipulate banked cells prior to administration. In vitro studies and a limited set of experimental in vivo studies have indicated that adverse immunological reactions may occur when allogeneic MSCs are administered to horses. However, newer studies lack evidence of inflammatory reactions or adverse clinical responses when allogeneic MSCs are administered and compared with autologous MSCs. Thus, while the relative merits of allogeneic vs autologous MSCs for treatment of musculoskeletal injuries in horses have not been fully established, accumulating evidence from studies in horses suggests that allogeneic MSCs maybe a safe alternative to autologous MSCs. Large, properly designed, randomised trials in addition to careful immunological evaluation of short‐term and long‐term, local and systemic immune responses are needed to more fully resolve the issue.
Broad domains of histone H3 lysine 4 trimethylation in transcriptional regulation and disease
Authors: Park Shinae , Kim Go Woon , Kwon So Hee , Lee Jung‐Shin
Published: January 2020

Histone modifications affect transcription by changing the chromatin structure. In particular, histone H3 lysine 4 trimethylation (H3K4me3) is one of the most recognized epigenetic marks of active transcription. While many studies have provided evidence of the correlation between H3K4me3 and active transcription, details regarding the mechanism involved remain unclear. The first study on the broad H3K4me3 domain was reported in 2014; subsequently, the function of this domain has been studied in various cell types. In this review, we summarized the recent studies on the role of the broad H3K4me3 domain in transcription, development, memory formation, and several diseases, including cancer and autoimmune diseases. The broadest H3K4me3 domains are associated with increased transcriptional precision of cell‐type‐specific genes related to cell identity and other essential functions. The broad H3K4me3 domain regulates maternal zygotic activation in early mammalian development. In systemic autoimmune diseases, high expression of immune‐responsive genes requires the presence of the broad H3K4me3 domain in the promoter‐proximal regions. Transcriptional repression of tumor‐suppressor genes is associated with the shortening of the broad H3K4me3 domains in cancer cells. Additionally, the broad H3K4me3 domain interacts with the super‐enhancer to regulate cancer‐associated genes. During memory formation, H3K4me3 breadth is regulated in the hippocampus CA1 neurons. Taken together, these findings indicate that H3K4me3 breadth is essential for the regulation of the transcriptional output across multiple cell types.
Rethinking geographies of race and austerity urbanism
Authors: Phinney Sawyer
Published: January 2020

Austerity has become a key consideration for studying ongoing state restructuring of the urban since the economic crisis of 2008. However, academic debates have yet to fully interrogate the role of race in this process. This article reviews geographic literature on race and austerity. It outlines the emergence of austerity urbanism, and the geographic, sociological, and political science literatures from which it draws its origins from. Focusing on the interplay between race/racialization and austerity, this article engages with critical theories of race to better understand the “raced” nature of austerity, and how these processes shape cities. Critical theories of race have been influential in linking race to forms of state power and governance in geography, while also exploring racism as a material and discursive formation that is connected across space and time by capital. Austerity urbanism literature has yet to develop a sophisticated analysis of the racialized dimensions of austerity in the U.S. context. Rather, scholarship up to date theorizes race through fixed categories, where racialized groups are seen and mapped onto austerity policy outcomes. In this paper, I propose that critical theories of race can provide an analytical framework for geographers to better understand the relations between race and austerity through the lens of racial capitalism by revealing how periods of neoliberalization are organized along racial lines and operate through and upon terrains of racial domination and empire. This means framing race and racism as a process (i.e., racialization) that is inextricably embedded in the logic of the neoliberal project. This paper concludes with commentary on possible future directions, both empirical and conceptual, that engagements with racial capitalism can offer to the literature on austerity urbanism to interrogate race, power, and justice across the Global North and South.
Ever‐transient FDI and ever‐polarizing regional development: Revisiting conventional theories of regional development in the context of China, Southeast and South Asia
Authors: Zhao Simon X. B. , Wong David W. H. , Wong David W. S. , Jiang Y. P.
Published: January 2020

In this new age of globalization, regions attempt to attract foreign direct investment (FDI) in order to achieve regionally balanced development. We revisit existing theories of regional development and FDI by analyzing recent data sets on FDI, employment, and trade in China, Southeast Asia, and South Asia. Using Chinese provincial data in 2004, 2008, and 2013 and applying panel estimations, our econometric results demonstrate that FDI remarkably influenced the concentration of employment in manufacturing, financial, and business services industries within the three Chinese macro‐regions. We also find that FDI is ever transient, always moving away from high‐cost to low‐cost production bases across different regions. This transient nature of FDI is spatially selective and biased, and not able to generate the trickle‐down effects to other neighboring regions. That is why FDI recently moved from China to Southeast and South Asia rather than from its coastal to inland regions. Furthermore, we show that this nature of FDI generally leads to polarization development for regions. As a synthesis or extension of the existing theories, we propose aleapfrog polarization pattern and strategyfor vast developing countries in considering their regional development strategies.
Three compartment bioimpedance spectroscopy in the nutritional assessment and the outcome of patients with advanced or end stage kidney disease: What have we learned so far?
Authors: Broers Natascha J. H. , Canaud Bernard , Dekker Marijke J. E. , van der Sande Frank M. , Stuard Stefano , Wabel Peter , Kooman Jeroen P.
Published: January 2020

Bioimpedance spectroscopy (BIS) is an easily applicable tool to assess body composition. The three compartment model BIS (3C BIS) conventionally expresses body composition as lean tissue index (LTI) (lean tissue mass [LTM]/height in meters squared) and fat tissue index (FTI) (adipose tissue mass/height in meters squared), and a virtual compartment reflecting fluid overload (FO). It has been studied extensively in relation to diagnosis and treatment guidance of fluid status disorders in patients with advanced‐stage or end‐stage renal disease. It is the aim of this article to provide a narrative review on the relevance of 3C BIS in the nutritional assessment in this population. At a population level, LTI decreases after the start of hemodialysis, whereas FTI increases. LTI below the 10th percentile is a consistent predictor of outcome whereas a low FTI is predominantly associated with outcome when combined with a low LTI. Recent research also showed the connection between low LTI, inflammation, and FO, which are cumulatively associated with an increased mortality risk. However, studies toward nutritional interventions based on BIS data are still lacking in this population. In conclusion, 3C BIS, by disentangling the components of body mass index, has contributed to our understanding of the relevance of abnormalities in different body compartments in chronic kidney disease patients, and appears to be a valuable prognostic tool, at least at a population level. Studies assessing the effect of BIS guided nutritional intervention could further support its use in the daily clinical care for renal patients.
Altered Hypothalamic Region Covariance in Migraine and Cluster Headache: A Structural MRI Study
Authors: Chong Catherine D. , Aguilar Maria , Schwedt Todd J.
Published: January 2020

Objectives

The hypothalamus plays a key role in both migraine and cluster headache (CH). As brain region‐to‐region structural correlations are believed to reflect structural and functional brain connectivity patterns, we assessed the structural covariance patterns between the volume of the hypothalamic region and vertex‐by‐vertex measurements of cortical thickness in patients with migraine and in those with CH relative to healthy controls (HC).

Methods

T1‐weighted images were acquired on a 3T MRI scanner for a total of 59 subjects including 18 patients with CH (age: mean = 43.8, SD = 12.4), 19 with migraine (age: mean = 40.1, SD = 12.2), and 22 HCs (age: mean = 39.1, SD = 8.2). Imaging was collected between attacks (migraineurs) and during out‐of‐bout phases (CH). Data were post‐processed using FreeSurfer version 6.0 and within‐group correlations between hypothalamic region volume with cortical thickness were explored using a whole‐brain vertex‐wise linear model approach. Between‐group differences in correlation slopes between hypothalamic region volume and vertex‐by‐vertex measurements of cortical thickness were interrogated using post‐hoc comparisons.

Results

There were no significant between‐group differences (migraine vs CH; migraine vs HC; or CH vs HC) for age, sex, total brain volume or volume of the left or right hypothalamic region. For each group, there were significant positive correlations (P < .01) between right and left hypothalamic region volumes with cortical thickness measurements. HC had significant positive correlations between hypothalamic region volume and cortical thickness over large portions of the superior and rostral medial frontal, orbitofrontal cortex and rostral anterior cingulate, and smaller clusters in the superior and middle temporal, posterior cingulate, fusiform, and precentral cortex. Post‐hoc analysis showed significant differences in covariance patterns in those with migraine and CH relative to HC, with both migraine patients and CH having weaker structural covariance of hypothalamic region volume with frontal and temporal cortical thickness.

Conclusion

Recent evidence suggests hypothalamic region connectivity to frontal and temporal areas to be relevant for regulating pain perception. Thus, the diminished structural covariance in migraineurs and CH might suggest abnormal functioning of the pain control circuitry and contribute to mechanisms underlying central sensitization and chronification of pain.
Sensory Hypersensitivity Symptoms in Migraine With vs Without Aura: Results From the American Registry for Migraine Research
Authors: Pearl Talia A. , Dumkrieger Gina , Chong Catherine D. , Dodick David W. , Schwedt Todd J.
Published: January 2020

Background and Objectives

Migraine with aura (MwA) is associated with increased brain hyper‐responsiveness to visual stimuli and increased visual network connectivity relative to migraine without aura (MwoA). Despite this, prior studies have provided conflicting results regarding whether MwA is associated with higher photophobia symptom scores compared to MwoA. The relationships between MwA and other types of sensory hypersensitivity, such as phonophobia and cutaneous allodynia (CA), have not been previously investigated. The purpose of this cross‐sectional observational study was to investigate whether MwA is associated with greater symptoms of photophobia, phonophobia, and CA compared to MwoA.

Methods

This analysis included 321 migraine patients (146 MwA; 175 MwoA) who had been enrolled into the American Registry for Migraine Research. The diagnosis of either MwoA or MwA was determined by headache specialists using ICHD diagnostic criteria. Patients completed the Photosensitivity Assessment Questionnaire, the Hyperacusis Questionnaire, and the Allodynia Symptom Checklist. Mean or median values were compared between groups. Regression models were created to analyze the relationship between MwA with photophobia scores, hyperacusis scores, and the presence of interictal CA.

Results

Those with MwA had higher mean photophobia scores than those with MwoA (4.1 vs 3.0, P = .0003). MwA was positively associated with photophobia symptom severity (B = 0.50 [SE = 0.14], P = .0003), after controlling for age, patient sex, and headache frequency. Aura was not associated with hyperacusis symptom severity (B = 0.07 [SE = 0.08], P = .346) or the presence of interictal CA (OR 1.33 [95% CI 0.70‐2.53], P = .381).

Conclusion

MwA is associated with higher photophobia symptom scores compared to MwoA. Aura is not associated with greater hyperacusis or interictal allodynia scores. These findings complement prior imaging and neurophysiologic studies that demonstrated MwA to be associated with hyper‐responsiveness of brain visual processing regions. The findings suggest that MwA is associated specifically with visual hypersensitivity, as opposed to being associated with a general hypersensitivity to multiple types of sensory stimuli.
Very high pacing thresholds during long‐term follow‐up predicted by a combination of implant pacing threshold and impedance in leadless transcatheter pacemakers
Authors: Tolosana José M. , Guasch Eduard , San Antonio Rodolfo , Apolo Jose , Pujol‐López Margarida , Chipa‐Ccasani Fredy , Trucco Emilce , Roca‐Luque Ivo  , Brugada Josep , Mont Lluís
Published: January 2020

Background

Micra transcatheter pacemaker system (TPS) usually achieves low implant pacing threshold (IPT). However, IPT may increase in some patients during follow‐up.

Aim

To apply implant parameters in predicting long‐term occurrence of very high pacing threshold (VHPT) in patients with Micra‐TPS.

Methods

A cohort of 110 consecutive patients implanted with a Micra‐TPS from 2014 to 2018 was evaluated at discharge and at 1, 12, 24, 36, and 48 months follow‐up. VHPT was defined as greater than 2 V/0.24 ms. VHPT predictors were identified.

Results

Micra‐TPS was implanted successfully in 108 patients (98.2%). During a mean follow‐up of 24 ± 16 months, 18 patients (16.7%) died of causes nonpacemaker‐related, and 4 (3.8%) developed VHPT. Patients with VHPT had higher IPT and lower implant impedance than patients with non‐VHPT: 1 ± 0.31 vs 0.55 ± 0.29 V/0.24 ms (P = .003) and 580 ± 59 vs 837 ± 232 Ω (P = .03), respectively. IPT and impedance had excellent discriminative power to predict VHPT (area under the curve: 0.85 ± 0.07 and 0.91 ± 0.05, respectively). Negative predictive value (NPV) of IPT ≤ 0.5 V/0.24 ms was 100%; positive predictive value (PPV) was 8% throughout follow‐up. Implant impedance ≤ 600 Ω had NPV of 99% throughout follow‐up, whereas PPV varied: 16%, 21%, 16%, and 28% at 1, 12, 24, and 36 months, respectively. Sequential combination of IPT greater than 0.5 V/0.24 ms and impedance ≤ 600 Ω improved PPV to 25%, 35%, 27%, and 44%, respectively, whereas NPV remained 99% throughout follow‐up.

Conclusion

Despite favorable long‐term electrical performance of Micra‐TPS, a small percent of patients developed VHPT during follow‐up. A sequential combination of IPT and impedance could allow the implanter to identify patients who will develop VHPT during long‐term follow‐up.
Identification of late‐stage pollen‐specific promoters for construction of pollen‐inactivation system in rice
Authors: Wang Menglong , Yan Wei , Peng Xiaoqun , Chen Zhufeng , Xu Chunjue , Wu Jianxin , Deng Xing Wang , Tang Xiaoyan
Published: January 2020

Large‐scale production of male sterile seeds can be achieved by introducing a fertility‐restoration gene linked with a pollen‐killer gene into a recessive male sterile mutant. We attempted to construct this system in rice by using a late‐stage pollen‐specific (LSP) promoter driving the expression of maize α‐amylase gene ZM‐AA1. To obtain such promoters in rice, we conducted comparative RNA‐seq analysis of mature pollen with meiosis anther, and compared this with the transcriptomic data of various tissues in the Rice Expression Database, resulting in 269 candidate LSP genes. Initial test of nine LSP genes showed that only the most active OsLSP3 promoter could drive ZM‐AA1 to disrupt pollen. We then analyzed an additional 22 LSP genes and found 12 genes stronger than OsLSP3 in late‐stage anthers. The promoters of OsLSP5 and OsLSP6 showing higher expression than OsLSP3 at stages 11 and 12 could drive ZM‐AA1 to inactivate pollen, while the promoter of OsLSP4 showing higher expression at stage 12 only could not drive ZM‐AA1 to disrupt pollen, suggesting that strong promoter activity at stage 11 was critical for pollen inactivation. The strong pollen‐specific promoters identified in this study provided valuable tools for genetic engineering of rice male sterile system for hybrid rice production.
Expression of α3β2β4 nicotinic acetylcholine receptors by rat adrenal chromaffin cells determined using novel conopeptide antagonists
Authors: Hone Arik J. , Rueda‐Ruzafa Lola , Gordon Thomas J. , Gajewiak Joanna , Christensen Sean , Dyhring Tino , Albillos Almudena , McIntosh J. Michael
Published: January 2020

Adrenal chromaffin cells release neurotransmitters in response to stress and may be involved in conditions such as post‐traumatic stress and anxiety disorders. Neurotransmitter release is triggered, in part, by activation of nicotinic acetylcholine receptors (nAChRs). However, despite decades of use as a model system for studying exocytosis, the nAChR subtypes involved have not been pharmacologically identified. Quantitative real‐time PCR of rat adrenal medulla revealed an abundance of mRNAs for α3, α7, β2, and β4 subunits. Whole‐cell patch‐clamp electrophysiology of chromaffin cells and subtype‐selective ligands were used to probe for nAChRs derived from the mRNAs found in adrenal medulla. A novel conopeptide antagonist, PeIA‐5469, was created that is highly selective for α3β2 over other nAChR subtypes heterologously expressed in Xenopus laevis oocytes. Experiments using PeIA‐5469 and the α3β4‐selective α‐conotoxin TxID revealed that rat adrenal medulla contain two populations of chromaffin cells that express either α3β4 nAChRs alone or α3β4 together with the α3β2β4 subtype. Conclusions were derived from observations that acetylcholine‐gated currents in some cells were sensitive to inhibition by PeIA‐5469 and TxID, while in other cells, currents were sensitive only to TxID. Expression of functional α7 nAChRs was determined using three α7‐selective ligands: the agonist PNU282987, the positive allosteric modulator PNU120596, and the antagonist α‐conotoxin [V11L,V16D]ArIB. The results of these studies identify for the first time the expression of α3β2β4 nAChRs as well as functional α7 nAChRs by rat adrenal chromaffin cells.

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The effectiveness of nurse‐led interventions for preventing urinary tract infections in older adults in residential aged care facilities: A systematic review
Authors: Wu Min‐Lin (Winnie) , Pu Lihui , Grealish Laurie , Jones Cindy , Moyle Wendy
Published: January 2020

Aims and Objectives

To explore the effectiveness of nurse‐led interventions to prevent urinary tract infections in older adults living in residential aged care facilities.

Background

While most empirical studies focus on the treatment of urinary tract infections, few studies have examined the effectiveness of nurse‐led interventions in preventing urinary tract infections.

Design

Systematic review.

Methods

Eight electronic databases were searched for relevant studies published between 2008–2018. The inclusion criteria were as follows: (a) a focus on older adults, (b) evaluation of nurse‐led interventions, focusing on prevention of urinary tract infection, (c) implemented in residential aged care facilities, and (d) outcomes reported as incidence or prevalence of urinary tract infection. The selected papers were critically appraised using the Mixed Methods Appraisal Tool. The data were analysed with narrative synthesis, and findings were reported following the PRISMA guidelines.

Results

A review of 1,614 titles and abstracts identified four studies that met the inclusion criteria. Three types of nurse‐led interventions were identified: (a) the appointment of advanced practice nurses, (b) those focused on a single specific nursing intervention, and (c) implementation of a multicomponent nursing intervention. All included studies reported at least some positive outcomes. However, the included studies were highly heterogeneous and it was impossible to determine the most effective intervention approach.

Conclusions

Nurses are leaders in health care and are well placed to lead prevention of urinary tract infections in residential aged care; however, evidence of the effectiveness of a nurse‐led approach is limited. High‐quality randomised controlled trials are warranted to address the knowledge gap and advance practice in this area.

Relevance to clinical practice

When developing an effective nurse‐led intervention programme, the programme should be grounded in nurse‐led principles and consider the complex staffing factors to ensure that nurse‐led programmes are tailored to an effective level.
Behavioral Repertoire of Families for Coping with Individuals with Hikikomori (Prolonged Social Withdrawal) in Japan1
Authors: Nonaka Shunsuke , Shimada Hironori , Sakai Motohiro
Published: January 2020

This study aimed to examine the characteristics of families’ behavioral repertoires in hikikomori (prolonged social withdrawal) cases. We asked 243 parents of individuals with hikikomori (hikikomori group) to complete the Family Behavioral Repertoire Scale for Coping With Hikikomori (FBS‐H), the Negative Evaluation of Hikikomori Scale, and a self‐efficacy measure of coping with problem behaviors of hikikomori in order to develop the FBS‐H and to examine its reliability and validity. Additionally, we examined the characteristics of hikikomori cases regarding the families’ behavioral repertoires using data from the hikikomori group and from 458 parents of individuals with no experience of hikikomori (control group). The results of the analysis indicated the acceptable reliability and validity of the FBS‐H. The hikikomori group did not have lower FBS‐H scores than the control group. This result indicates the possibility that a family's behavioral repertoire does not strongly influence the “expression” of hikikomori. Further research is needed to clarify the influence of families’ behavioral repertoires to refine family support.
Revisiting Australian Ectocarpus subulatus (Phaeophyceae) From the Hopkins River: Distribution, Abiotic Environment, and Associated Microbiota
Authors: Dittami Simon M. , Peters Akira F. , West John A. , Cariou Thierry , KleinJan Hetty , Burgunter‐Delamare Bertille , Prechoux Aurélie , Egan Suhelen , Boyen Catherine
Published: January 2020

In 1995 a strain of Ectocarpus was isolated from Hopkins River Falls, Victoria, Australia, constituting one of few available freshwater or nearly freshwater brown algae, and the only one belonging to the genus Ectocarpus. It has since been used as a model to study acclimation and adaptation to low salinities and the role of its microbiota in these processes. To provide more background information on this model, we assessed if Ectocarpus was still present in the Hopkins river 22 years after the original finding, estimated its present distribution, described its abiotic environment, and determined its in situ microbial composition. We sampled for Ectocarpus at 15 sites along the Hopkins River as well as 10 neighboring sites and found individuals with ITS and cox1 sequences identical to the original isolate at three sites upstream of Hopkins River Falls. The salinity of the water at these sites ranged from 3.1 to 6.9, and it was rich in sulfate (1–5 mM). The diversity of bacteria associated with the algae in situ (1312 operational taxonomic units) was one order of magnitude higher than in previous studies of the original laboratory culture, and 95 alga‐associated bacterial strains were isolated from algal filaments on site. In particular, species of Planctomycetes were abundant in situ but rare in laboratory cultures. Our results confirmed that Ectocarpus was still present in the Hopkins River, and the newly isolated algal and bacterial strains offer new possibilities to study the adaptation of Ectocarpus to low salinity and its interactions with its microbiome.
Thermal and porosity properties of meteorites: A compilation of published data and new measurements
Authors: Soini A.‐J. , Kukkonen I. T. , Kohout T. , Luttinen A.
Published: January 2020

We report direct measurements of thermal diffusivity and conductivity at room temperature for 38 meteorite samples of 36 different meteorites including mostly chondrites, and thus almost triple the number of meteorites for which thermal conductivity is directly measured. Additionally, we measured porosity for 34 of these samples. Thermal properties were measured using an optical infrared scanning method on samples of cm‐sizes with a flat, sawn surface. A database compiled from our measurements and literature data suggests that thermal diffusivities and conductivities at room temperature vary largely among samples even of the same petrologic and chemical type and overlap among, for example, different ordinary chondrite classes. Measured conductivities of ordinary chondrites vary from 0.4 to 5.1 W m−1 K−1. On average, enstatite chondrites show much higher values (2.33–5.51 W m−1 K−1) and carbonaceous chondrites lower values (0.5–2.55 W m−1 K−1). Mineral composition (silicates versus iron‐nickel) and porosity control conductivity. Porosity shows (linear) negative correlation with conductivity. Variable conductivity is attributed to heterogeneity in mineral composition and porosity by intra‐ and intergranular voids and cracks, which are important in the scale of typical meteorite samples. The effect of porosity may be even more significant for thermal properties than that of the metal content in chondrites.
Breastfeeding initiation or duration and longitudinal patterns of infections up to 2 years and skin rash and respiratory symptoms up to 8 years in the EDEN mother–child cohort
Authors: Davisse‐Paturet Camille , Adel‐Patient Karine , Forhan Anne , Lioret Sandrine , Annesi‐Maesano Isabella , Heude Barbara , Charles Marie Aline , de Lauzon‐Guillain Blandine
Published: January 2020

This paper aimed to examine the effect of breastfeeding on longitudinal patterns of common infections up to 2 years and respiratory symptoms up to 8 years. To assess the incidence and reoccurrence of infections and allergic symptoms in the first years of life among 1,603 children from the EDEN mother–child cohort, distinct longitudinal patterns of infectious diseases as well as skin rash and respiratory symptoms were identified by group‐based trajectory modelling. To characterize infections, we considered the parent‐reported number of cold/nasopharyngitis and diarrhoea from birth to 12 months and otitis and bronchitis/bronchiolitis from birth to 2 years. To characterize allergy‐related symptoms, we considered the parent‐reported occurrence of wheezing and skin rash from 8 months to 8 years and asthma from 2 to 8 years. Then associations between breastfeeding and these longitudinal patterns were assessed through adjusted multinomial logistic regression. Compared with never‐breastfed infants, ever‐breastfed infants were at a lower risk of diarrhoea events in early infancy as well as infrequent events of bronchitis/bronchiolitis throughout infancy. Only predominant breastfeeding duration was related to frequent events of bronchitis/bronchiolitis and infrequent events of otitis. We found no significant protective effect of breastfeeding on longitudinal patterns of cold/nasopharyngitis, skin rash, or respiratory symptoms. For an infant population with a short breastfeeding duration, on average, our study confirmed a protective effect of breastfeeding on diarrhoea events in early infancy, infrequent bronchitis/bronchiolitis and, to a lesser extent, infrequent otitis events up to 2 years but not on other infections, skin rash, or respiratory symptoms4.
Applicability of machine learning to a crack model in concrete bridges
Authors: Okazaki Yuriko , Okazaki Shinichiro , Asamoto Shingo , Chun Pang‐jo
Published: January 2020

The growing demand for a more efficient maintenance of concrete bridges requires a model that tracks the deterioration of each bridge based on inspection data. Although it has been expected that machine learning could be applied to this problem, inspection data sparsely distributed over time are not suitable for machine learning in contrast to the continuous big data usually targeted. This study applies machine learning to a regression model of crack formation and propagation using inspection data to confirm the applicability. It includes the selection of the optimal algorithm, development of the model based on a novel methodology, and factor analysis using the model. Accordingly, the model was constructed by Gaussian process regression and it could appropriately extract the differences in the progress of crack damage due to multiple influential factors. The results demonstrate the excellent applicability of machine learning even to sparse data.
Nitric oxide as a developmental and metabolic signal in filamentous fungi
Authors: Zhao Yanxia , Lim Jieyin , Xu Jianyang , Yu Jae‐Hyuk , Zheng Weifa
Published: January 2020

The short‐lived hydrophobic gas nitric oxide (NO) is a broadly conserved signaling molecule in all domains of life, including the ubiquitous and versatile filamentous fungi (molds). Several studies have suggested that NO plays a vast and diverse signaling role in molds. In this review, we summarize NO‐mediated signaling and the biosynthesis and degradation of NO in molds, and highlight the recent advances in understanding the NO‐mediated regulation of morphological and physiological processes throughout the fungal life cycle. In particular, we describe the role of NO in molds as a signaling molecule that modulates asexual and sexual development, the formation of infection body appressorium, and the production of secondary metabolites (SMs). In addition, we also summarize NO detoxification and protective mechanisms against nitrooxidative stress.
Radical Orthodoxy on Catholicism, Protestantism and Liberalism/Liberality: On the Use of Historical Narratives and Quantitative Methods in Political Theology
Authors: Rasmusson Arne
Published: January 2020

Political theology assumes or depends, implicitly or explicitly, on historical narratives and empirical claims. For theologians making historical, socio‐cultural and economic claims an interdisciplinary use of several different methods is helpful, including a theologically and philosophically informed combination of historical narratives with social and economic quantitative methods. This argument is fleshed out by a critical analysis of historical and sociological claims about Catholicism, Anglicanism, and Protestantism in relation to liberalism and liberality, which are central to the argument of John Milbank’s and Adrian Pabst’s book The Politics of Virtue. They find the roots of an increasingly untenable abstract atomistic liberalism both in late medieval and Protestant (especially Calvinist) theology as well as in the dissenting nonconforming traditions that worked for the disestablishment of the Church. This very disestablishment is part of what creates modern liberalism. This article both sketches a partly alternative history to the one Milbank and Pabst provide, pointing to the role of creative minorities in certain dissenting Protestant churches and movements for the emergence of the type of liberality Milbank and Pabst defend, and tests these claims against quantitative social science studies on democracy, social trust, and corruption.
A puzzle about the experience of left and right
Authors: Cutter Brian
Published: January 2020

Imagine your mirror‐inverted counterpart on Mirror Earth, a perfect mirror image of Earth. Would her experiences be the same as yours, or would they be phenomenally mirror‐inverted? I argue, first, that her experiences would be phenomenally the same as yours. I then show that this conclusion gives rise to a puzzle, one that I believe pushes us toward some surprising and philosophically significant conclusions about the nature of perception. When you have a typical visual experience as of something to your left, the following three claims seem very plausible: (1) No one could have an experience phenomenally just like yours without thereby having an experience as of something to her left. (2) Your experience is veridical. (3) Your experience doesn't differ from that of your mirror‐inverted counterpart with respect to veridicality. But (1)‐(3) jointly contradict the claim that you and your mirror‐inverted counterpart would have the same experiences. I argue that any viable response to this puzzle will embrace the following disjunction: either there is a degree of independence between perceptual phenomenology and representational content, contrary to popular intentionalist views of perception, or spatial subjectivism is true, where spatial subjectivism is the view that the spatial properties presented in perception are either mind‐dependent or illusory.
Sputum transcriptomics: A tool for identifying gene expression underlying mechanistic pathways in severe asthma
Authors: Hodge Sandra
Published: January 2020

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A study of igneous rocks related to Zn–Pb mineralization in the Shinyemi and Gagok deposits of the Taebaeksan Basin, South Korea
Authors: Seo Jieun , Choi Seon‐Gyu , Koo Minho , Oh Chang Whan , Ryu In–Chang , Lee Gilljae
Published: January 2020

The Shinyemi and Gagok deposits, located in the Taebaeksan Basin, South Korea, display Zn–Pb mineralization along a contact between Cretaceous granitoids and Cambrian–Ordovician carbonates of the Joseon Supergroup. The Shinyemi mine is one of the largest polymetallic skarn‐type magnetite deposits in South Korea and comprises Fe and Fe–Mo–Zn skarns, and Zn–Cu–Pb replacement deposits. Both deposits yield similar Cretaceous mineralization ages, and granitoids associated with the two deposits displaying similar mineral textures and compositions, are highly evolved, and were emplaced at a shallow depth. They are classified as calc‐alkaline, I‐type granites (magnetite series) and were formed in a volcanic arc. Compositional variation is less in the Shinyemi granites and aplites (e.g., SiO2 = 74.4–76.6 wt% and 74.4–75.1 wt%, respectively) than in the Gagok granites and aplites (e.g., SiO2 = 65.6–68.0 wt% and 74.9–76.5 wt%, respectively). Furthermore, SiO2 vs K/Rb and SiO2 vs Rb/Sr diagrams indicate that the Shinyemi granitoids are more evolved than the Gagok granitoids. Shinyemi granitoids had been already differentiated highly in deep depth and then intruded into shallow depth, so both granite and aplite show the highly evolved similar chemical compositions. Whereas, less differentiated Gagok granitoids were separated into two phases in the last stage at shallow depth, so granite and aplite show different compositions. The amounts of granites and aplite are similar in the Shinyemi deposit, whereas the aplite appears in an amount less than the granite in the Gagok deposit. For this reason, the Shinyemi granitoids caused not only Fe enrichment during formation of the dolomite‐hosted magnesian skarn but also was associated with Mo mineralization in the Shinyemi deposit. Zn mineralization of the Gagok deposit was mainly caused by granite rather than aplite. Our data suggest that the variation in mineralization displayed by the two deposits resulted from differences in the compositions of their associated igneous intrusions.
Mobile money, risk sharing, and educational investment: Panel evidence from rural Uganda
Authors: Tabetando Rayner , Matsumoto Tomoya
Published: January 2020

We examine the impact of the rapidly expanding mobile banking service “mobile money” on rural households' ability to smooth investment in schooling after a negative shock. We find that a negative shock induces a 9.3‐percentage point decrease in per school‐age child educational expenditure for households who do not use mobile money compared to an 8.3‐percentage point decrease for households that have adopted mobile money. The underlying mechanism is an increase in remittance receipt and the diversity of senders owing to the reduction in transactions cost provided by mobile money. We show that our results are robust to alternative mechanisms. We use the expansion in mobile money agent network as an exogenous variation in access to mobile money.
Elections and Policy Responsiveness: Evidence from Environmental Voting in the U.S. Congress
Authors: McAlexander Richard J. , Urpelainen Johannes
Published: January 2020

Do elections affect legislators' voting patterns? We investigate this question in the context of environmental policy in the U.S. Congress. We theorize that since the general public is generally in favor of legislation protecting the environment, legislators have an incentive to favor the public over industry and vote for pro‐environment legislation at election time. The argument is supported by analyses of data on environmental roll call votes for the U.S. Congress from 1970 to 2013 where we estimate the likelihood of casting a pro‐environment vote as a function of the time to an election. While Democrats are generally more likely to cast a pro‐environment vote before an election, this effect is much stronger for Republicans when the legislator won the previous election by a thinner margin. The election effect is maximized for candidates receiving substantial campaign contributions from the (anti‐environment) oil and gas industry. Analysis of Twitter data confirms that Congressmembers make pro‐environmental statements and highlight their roll call voting behavior during the election season. These results show that legislators do strategically adjust their voting behavior to favor the public immediate prior to an election.
Going beyond a positive–negative dichotomy in judgment and decision‐making research: Insights for framing, counterfactual thinking, and ambivalence
Authors: Sparks Jehan
Published: January 2020

Many areas of judgment and decision‐making research have historically relied on a simple positive–negative dichotomy (e.g., positive vs. negative framing). Although this classic assumption about the conceptual space has contributed to some of the field's more impactful findings (e.g., framing effects), it may also have mistakenly led us to believe that these findings told a complete story about biases in processing positive and negative information. Building on a tradition of theoretical accounts outlining how positive and negative information is more complex, the first part of this paper considers how the following three elements jointly help to tell a more complete story about framing effects: (a) regulatory focus theory's concept of the domain (loss vs. gain) of an outcome, (b) the sequencing of positive and negative frames, and (c) the asymmetric influences of positive and negative evaluative processes. Next, the paper reviews research that has contributed to integrating these elements, highlighting opportunities for further integration to generate new insights for framing effects, risky decision‐making, counterfactual thinking, and ambivalence. The reviewed studies suggest that a more sophisticated conceptualization of positive and negative information contributes to a deeper understanding of the basic processes that govern human judgment and decision‐making.