bluuebunny/crossref_metadata_2025 huggingface dataset:
Setting up of an Integrative Center for the Management of Mild-moderate COVID-19
Authors: Nesari Tanuja Manoj , Dharmarajan Prasanth , Mahapatra Arun Kumar , Rajagopala S , Nesari Manoj , Kapoor Alka , Bhati Deepak , Kumar Anil , Kumari Sonam , Arshathjyothi P S , Dileep Aparna
Published: June 2022

Introduction:

Besides the expansion of vaccine drive, the discovery of new strains of corona virus is creating havoc all around the world. Based on the pragmatic trial conducted, there is an increasing recognition that an effective integrated holistic approach is urgently needed to combat the COVID pandemic. During an infectious outbreak, a health-care unit is anticipated to function as a high-level isolation unit. Herein, we describe the execution plan, experiences, observations, and challenges that were encountered during the establishment and functioning of COVID Health-Care Ward at All India Institute of Ayurveda.

Methodology:

Since the situation was novel, standard operative procedures and protocols were developed accordingly. Strategic plans carried out in infrastructure, biomedical waste management, surveillance, and observations were compiled directly from the hospital administration.

Results:

Till date when the 29th team has completed the duty rotation, about 600 COVID mild-to-moderate positive cases have been successfully managed. Zero incidence of nosocomial COVID transmission or death has been reported so far. The recovery speed of patients was found to be remarkably faster at COVID Health Center-AIIA as compared to all other hospitals of the state and a significant number of patients were recovered with the use of Ayurvedic medications alone. On follow-up, only a limited number of patients (two patients) turned up with mild severity of post-COVID complications. Mild respiratory discomfort was noted in these patients for a period of 2 months. The score for Anxiety Depression Scale of among patients and health-care workers reduced significantly.

Conclusion:

Indigenous system of medicines is comparatively less explored in pandemic times. Here, a tertiary care hospital has upgraded to integrative health-care model in the management of mild-to-moderate COVID-19 cases.
Comparison of performance of undergraduate medical students trained in conventional and integrated curriculums
Authors: Abbas Seyyedha , Sadiq Naushaba , Zehra Tabassum , Ullah Ihsan , Adeeb Humera
Published: June 2022

Introduction:

Foundation University Medical College is one of the few institutions in Pakistan that have developed an Integrated Modular Teaching Program. This mode of teaching is a novel addition to our conventional system and needs evaluation. The objective of this study was to compare the overall cumulative results of undergraduates from (Group A/2015) conventional (old) with (Group B/2016) integrated (new curriculum) final professional examinations and to correlate the overall cumulative results of final professional examinations with their admission test results.

Materials And Methods:

We compared the final professional examination results of Group A and Group B undergraduates. Both the groups had identical final examinations in terms of pattern, subjects, examiners, and duration. In addition, a measure of central tendency and standard deviation was calculated and made comparisons between entry and final professional examination results. Finally, the t-test was used to compare the theoretical and practical scores. In addition, it established the reliability and validity of the results.

Results:

The overall performance of undergraduates who trained on integrated curriculum (97.0%) was better than that of undergraduates who had trained on conventional curriculum (85.2%). Comparison between the various components of the professional examinations using the ANOVA test also revealed that the same group of undergraduates performed better with P < 0.05, which is 0.002, which showed significant results. Cronbach's alpha for overall performance was 0.957, whereas for the theoretical and practical examinations, it was 0.792 and 0.897, respectively.

Conclusion:

The results revealed that the undergraduates who had trained on integrated curriculum had improved performance in the final professional examinations both in theory and practical.

The following core competencies are addressed in this article:

Medical Knowledge, Practice-based learning and improvement, Systems-based practice, and Interpersonal and communication skills.
The proportion of hand and knee osteoarthritis and its associated risk factors among an urban diabetic population
Authors: Pathak Barsha Gadapani , Rahini S , Manapurath Rukman Mecca
Published: June 2022

Introduction:

Osteoarthritis (OA) is found to be a leading cause of disability in people with diabetes mellitus (DM). This study aimed to find the proportion of knee OA and hand OA and its risk determinants among people with DM.

Materials and Methods:

A cross-sectional study was conducted among 258 diabetic subjects attending the general outpatient department of a tertiary care hospital over 4 months. A predesigned case record form was used to collect details on sociodemographic profiles and various factors related to OA. The American College of Rheumatology criteria were used for the diagnosis of both knee and hand OA. Data analysis was done using the SPSS version 16. Chi-square/Fisher's exact test was used wherever applicable to find the association of various factors with OA.

Results:

The overall proportion of OA in diabetic subjects was 48.4%. The proportion of only hand OA was 25.2%, only knee OA was 14.3%, and both hand OA and knee OA were 8.9%. Age, female sex, duration of DM, irregularity in taking diabetic medications, hypertension, menopause, and body mass index were found to be significantly associated with both hand and knee OA. Physical inactivity and previous joint injury were found to be associated with knee OA. An inverse association with alcohol consumption was found. On logistic regression, we found irregularity in taking diabetic medication to be a significant risk factor for hand and knee OA. The duration of DM and taking alternate medications for DM were also found to be significant risk factors for hand OA. Prior knee injury is a significant risk factor for knee OA.

Conclusion:

There exists an association between OA and DM, and this suggests the need for early diagnosis, good disease management, and medication adherence and to implement preventive strategies so as to prevent further disabilities and improve quality of life.

The following core competencies are addressed in this article:

Patient care and procedural skills, Medical knowledge, Systems-based practice, Practice-based learning and improvement.
Development and training of mental health professionals in providing psychological intervention and support for women survivors of intimate partner violence – A pre–post evaluation study
Authors: Vranda Mysore Narasimha , Kumar Channaveerachari Naveen , Janardhana Navaneetham
Published: June 2022

Context:

Health care providers play a significant role as they are the first contact for seeking help for intimate partner violence (IPV) survivors.

Aims:

This research aimed toward developing a comprehensive culturally appropriate intervention package for the mental health professionals (MHPs) to provide psychological intervention and support for women survivors of IPV and test the training impact on the level of attitude, knowledge, and preparedness to respond to IPV disclosure among MHPs.

Settings and Design:

A single group, pre–post intervention study, was conducted at Tertiary Mental Health Hospital in the Southern part of India, Bengaluru.

Materials and Methods:

A total of 30 MHPs were recruited for the study using purposive sampling. MHP Attitude, Knowledge, Preparedness to Manage IPV (MAP–IPV) questionnaire was used to collect the data.

Statistical Analysis Used:

Descriptive statistics were used to assess the sociodemographic characteristics of the participants. The pre–post evaluation was analyzed using the independent “t” test by comparing the means scores of the MAP–IPV questionnaire. The data were analyzed using the Statistical Package for the Social Sciences (SPSS) – 20 version of the software.

Results:

The results revealed a lack of attitude, knowledge preparedness, and available resources materials among MHPs in addressing IPV cases. Pre–post evaluation showed statistically significant improvement in attitude, knowledge, and preparedness to identify and respond to IPV disclosure among MHPs after the intervention program.

Conclusion:

The comprehensive IPV intervention package effectively brings gain in attitude, knowledge, and preparedness among MHPs in addressing survivors of IPV. Practice guidelines and clear referral pathways following IPV disclosure need to be implemented to support the gains made through the training.
A Rare Case of the Right Atrial Diverticulum Encroaching the Left Ventricle
Authors: Kodandarama Usha Mandikal , Chaudhury Arnab Ghosh , Bhat Prabhavathi , Nanjappa Manjunath Cholenahally
Published: June 2022

Single diverticulum of the right atrium is a rare congenital malformation. We describe echocardiographic and computed tomography scan findings of a congenital right atrial diverticulum and its successful surgical resection in a 5-year-old boy. A review of available literature is also done discussing the possible etiology and management of this disease entity.
Adenoid Cystic Carcinoma of Palate
Authors: Datta Mainak , Sinha Rupam , Sarkar Soumyabrata , Shome Sayani
Published: June 2022

Adenoid cystic carcinoma (ADCC) is one of the malignant salivary gland neoplasm and constitutes for 1% of head and neck malignancies and 22% of all salivary gland malignancies. Palate is the most common site to be involved in the oral cavity followed by parotid region, tongue, and floor of mouth. It is commonly seen in middle age population with slight female predilection. It usually appears as asymptomatic, slow growing infiltrative growth with high recurrence, often presence of perineural invasion which appears as pain. In this present case of ADCC, a 65-year-old female patient reported with a swelling on the left side of hard palatal area since 3 months with occasional pain and history of epistaxis, which was diagnosed clinically, radiographically, and histopathologically and confirmed by immunohistochemistry as Grade III solid variety of ADCC with a poor prognosis.
Quantitative and Qualitative Palatal Rugae Pattern Analysis in Population of Punjab
Authors: Behl Ashima B. , Vinod VC , Kaur Jaswinder , Vohra Puneeta , Kaur Sumit , Bali Vikram
Published: June 2022

Background:

Palatal rugae are irregular, asymmetric ridges of mucous membrane extending laterally from incisive papillae and anterior part of palatal raphe. Palatal rugae patterns are unique to individuals.

Aim and Objectives:

The aim of the study was to identify a pattern of palatal rugae in terms of size, shape, number, and to compare rugae patterns in males and females of Punjab population.

Material and Methods:

A total of 420 diagnostic maxillary casts (210 men and 210 women) were randomly collected from various dental clinics and were subjected to visualization using graphite pencil and magnifying glass under adequate light. Student t test using SPSS software version 20 was utilized for statistical analysis.

Results:

Total of 3,465 rugae were observed. Out of the total rugae examined, primary type of rugae were found to be more followed by secondary and fragmentary/tertiary. On the basis of shape, it was found to be straight followed by wavy, curved, and circular. On the basis of modified Kapali classification, converging type of rugae were found to be more in men and diverging type were found to be more in women. The mean rugae were found to be more in women than men. Statistically significant values were observed in relation to size (secondary type), and shape (curved and circular).

Conclusion:

The present study was localized to the population of Punjab. Not many studies with such a large sample size have been done for this region. Palatal rugae pattern is definitely a sufficient characteristic to discriminate between genders.
Analysis Report of Adherence to Consort Statement for Reporting Randomized Controlled Trials (RCTs) Associated with Temporomandibular Disorders (TMDs)
Authors: Shete-Motgi Anagha , Shete Mrinal , Bhate Kalyani , Kshirsagar Kapil , Kakodkar Pradnya
Published: June 2022

Purpose:

Temporomandibular disorders (TMDs) and their management are widely sought after by clinicians. They often refer to the reported randomized controlled trials (RCTs) in the literature. The Consolidated Standards of Reporting Trials (CONSORT) statement aims to improve the quality of published RCTs and is endorsed by healthcare journals. Despite the widespread acceptance of CONSORT, its use for reporting clinical trials in the journals remains suboptimal. The purpose of this study was to evaluate, to what extent RCTs related to TMDs have adhered to the CONSORT statement.

Methodology:

RCTs related to TMDs, published in PubMed from January 2017 to March 2021 were retrieved. Each article was assessed for its adherence to the CONSORT statement by four trained and calibrated investigators.

Results:

88 articles were evaluated. Out of 37 items in the checklist, only 4 items demonstrated 100% adherence (item 2a, 2b, 5, 12a, and 16). The most under-reported items were 7a, 8b, 9, 10, 17a, 17b, 19, 23, and 24 (less than 50%). The mean percentage of adherence remained 71.2 ± 12.6. Only one study showed 100% adherence and three studies had less than 50% adherence. Considering adherence of abstract checklist, three items demonstrated 100% adherence (items 4, 5, and 6). Poor reporting was noted with items 8, 13, 15, and 16. The mean percentage of adherence to abstract reporting remained 68.60 ± 11.79.

Conclusion:

The present study indicates good adherence to CONSORT statement in reporting RCTs related to TMD management. Probably the mandatory instructions from the journals and increasing awareness among the researchers about CONSORT reporting might have done the trick.
Evaluation of Ayurvedic Treatment Modalities for Oral Lichen Planus – A Systematic Review
Authors: Gupta Subhadeep A. , Khare Vikram V. , Gaikwad Trupti V. , Chavan Mahesh S.
Published: June 2022

Oral lichen planus (OLP), a chronic inflammatory disease that affects the oral mucosa, may cause pain or discomfort along with increased burning sensation. There are numerous treatment modalities available that have several side effects. The aim of this study was to determine the effectiveness of Ayurvedic management for oral Lichen Planus. Two sources of Internet were used to search appropriate articles which satisfied the purpose of study including PubMed and Google scholar. Studies which were done on Indian population, PubMed search including articles that were published between January 1, 2000 and October 31, 2019, Studies published in English or which could be translated to English, randomized clinical trials, controlled clinical trials and longitudinal studies with essential data on Ayurvedic approach were included. Patients having Oral Lichen Planus where ayurvedic approach was used for treatment. Out of 09 articles, included in systematic review, in almost all the studies improvement in pain, erythema and burning sensation were reported in score scale. Administration of topical herbal antioxidants and topical application of herbal medicines prove to be effective approach in minimizing the signs and symptoms of Oral Lichen Planus. Long-term use of steroids has many side effects while the herbal medicines almost have none. So, herbal medicines can be used for better efficacy with least side effects for OLP.
The patient with obesity and super-super obesity
Authors: Kaye Alan D. , Lingle Brock D. , Brothers Jordan C. , Rodriguez Jessica R. , Morris Anna G. , Greeson Evan M. , Cornett Elyse M.
Published: June 2022

Obesity is associated with increased morbidity and mortality related to many complex physiologic changes and the rise worldwide has had far ranging implications in healthcare. According to the World Health Organization, over 2.8 million people die each year from being overweight or obese. Patients who are obese often need surgical procedures or interventional pain procedures and are at higher risk of complications. Patients with super-super obesity are those with body mass index greater than 60 kg/m2 and are at even greater risk for complications. The present investigation reviews epidemiology, pathophysiology, and anesthesia considerations for best practice strategies in managing these higher risk patients. Clinical anesthesiologists must utilize careful assessment and consultation in developing safe anesthesia plans. Improvements in technology have advanced safety with regard to airway management with advanced airway devices and in regional anesthesia with ultrasound-guided nerve blocks that can provide increased flexibility in formulating a safe anesthetic plan. As well, newer drugs and monitors have been developed for perioperative use to enhance safety in patients with obesity.
Contribuições para a harmonização de estimativas de atributos florestais por área de inventários florestais de larga escala
Authors: Vibrans Alexander Christian , Oliveira Laio Zimermann , Lingner Débora Vanessa , Gasper André Luís de
Published: June 2022

Em inventários florestais de larga escala, regionais ou nacionais, dados de campo são coletados em unidades amostrais (UAs) de área fixa, alocadas sistemática ou aleatoriamente, sendo elas total ou parcialmente cobertas por florestas. Nesta nota científica, são abordadas diferenças entre a predição de um atributo florestal por unidade de área que leva em consideração outros usos da terra além de floresta, e quando se considera apenas a área efetivamente florestada. A primeira é uma predição mais realista para um ponto amostral, enquanto a segunda é comparável a estudos clássicos de fitossociologia.
Oat, Buckwheat and Whole Brown Rice Flours as a Potential Prebiotic for Lactobacillus acidophilus (LA5), Lactobacillus casei and Bifidobacterium animalis subsp. lactis (BB-12)
Authors: DAŞNİK ŞEKER Feride , AKIN Mutlu
Published: June 2022

The object of this study was to determine whether oat, buckwheat and whole brown rice flours have a prebiotic effect on Lactobacillus casei, Lactobacillus acidophilus (LA5), and Bifidobacterium animalis subsp lactis (Bifidobacterium BB-12). In the study, skimmed milk was inoculated with the above-mentioned bacteria fortified with oat, buckwheat and whole brown rice flours. According to the results, oat and buckwheat flours stimulated all bacteria investigated, whereas whole brown rice flour had no prebiotic effect for L. casei.
Riesgos asociados con el trabajo y sus efectos en la salud, responsabilidad social empresarial. Ordenamiento jurídico Mexicano.
Authors: Almada Quintero María , Medina Wahnnatah Armando , Reyes Robles Marina , López Esquerra Luis , Medina Almada María , Medina Almada Ana
Published: June 2022

El presente trabajo consiste en una revisión teórica sobre  los riesgos asociados a la actividad laboral y sus efectos en la salud de los trabajadores, llevando a cabo una selección y análisis de trabajos o estudios realizados que guardan relación con el tema de este trabajo y que sirven como punto de referencia. Hoy en día las personas que laboran en escenarios productivos convierten a la empresa en un segundo hogar, pues ahí es donde se pasa la mayor parte de su tiempo. Actualmente es habitual encontrar que un trabajador, realice tareas ajenas a su puesto, así como también, con frecuencia se le pide realizar actividades fuera del horario establecido. En este sentido, cuando las exigencias son excesivas, la sobrecarga de trabajo puede repercutir en graves problemas, atentando la integridad física y salud del trabajador. Considerando estas situaciones como parte de la responsabilidad social de las organizaciones y su relación con las disposiciones del marco normativo en materia de riesgos laborales en México.
ACCEPTANCE, CONCERNS AND KNOWLEDGE OF COVID-19 VACCINE: AN EARLY BATTLE AGAINST THE PANDEMIC
Authors:   Universiti Sains Islam Malaysia, ISMAIL SHAHRINA , SYED MOHAMAD SHARIFAH FAIRUZ ,   Universiti Sains Islam Malaysia, SYED MOHAMAD SHARIFAH NAJWA ,   Universiti Sains Islam Malaysia, ROSLI FATIN AHZA ,   Universiti Sains Islam Malaysia
Published: June 2022

Many COVID-19 vaccine candidates were clinically tested in response to the coronavirus pandemic. This study aims to determine the acceptance rate of, main concerns about and knowledge of COVID-19 vaccination among the Malaysian population based on different sociodemographic characteristics during the early stages of vaccine arrival in Malaysia. A cross-sectional online survey was performed between January 25, 2021 and February 1, 2021 using descriptive statistics, Likert scale analysis, hypothesis testing, correlation and regression. These statistics assessed the correlation between sociodemographic characteristics, exposure to COVID-19 vaccine information, as well as the perceived risk of infection and acceptance towards COVID-19 vaccines. There exist significant differences across sociodemographic variables. More than half of the respondents (58.85%) voted safety as their primary concern. Moreover, a medium correlation exists between knowledge and acceptance, r = 0.444, N = 2051, p<0.01. The linear regression equation of acceptance predicted by knowledge was Acceptance = 2.873 + 0.981 (Knowledge). This study’s findings can help the government design the best way to execute COVID-19 vaccination campaigns in Malaysia, for example, the National COVID-19 Immunisation Programme. It also demonstrates that online questionnaires are appropriate for assessing health literacy skills and attitudes towards vaccination during infectious disease epidemics. It can also aid in the adaptation of medical communication tactics to better comprehend vaccination values.
PLASTICIZED CMC-AMMONIUM ACETATE BASED SOLID BIOPOLYMER ELECTROLYTE: IONIC CONDUCTIVITY AND TRANSPORT STUDY
Authors:   Universiti Sains Islam Malaysia, AHMAD SOHAIMY MOHD IBNU HAIKAL , ZAINUDDIN NURUL IZZATI ,   Universiti Sains Islam Malaysia, MOHAMAD ISA IKMAR NIZAM ,   Universiti Sains Islam Malaysia
Published: June 2022

In this work, a plasticised carboxymethyl cellulose (CMC) solid biopolymer electrolytes (PSBEs) system was prepared via solution casting technique with ammonium acetate (NH4CH3COO), ethylene glycol (EG) as doping salt and plasticiser respectively. Upon addition of 35 wt.% of EG (PSBE 4), the ionic conductivity obtained is 1.81 × 10-5 Scm-1 which represents the optimum value for the system. The PSBE also tested at elevated temperatures and fitted to an Arrhenius equation. Fourier Transform Infrared Spectroscopy (FTIR) analysis found no significant changes to the molecular structure of CMC with addition of EG. Jonscher’s power law indicates that quantum tunnelling is the well-matched model to describe ionic conduction for PSBE 4 and it appears that it is also highly ionic with good transference number obtain from dc polarisation analysis technique.
Radiofrequency Current at 448 Khz For Female Pattern Hair Loss: Cellular Bases For Redensification Improvement
Authors: Pablo Naranjo
Published: June 2022

Objective: Capacitive-Resistive Electrothermal Therapies (CRET) have proven effective in tissue regeneration. This study analyzes the response to 448-kHz CRET treatment in 20 patients with Female Pattern Hair Loss (FPHL) and in woman’s Dermal Papilla Cells (DPC).

Methods: Patients received ten 20-minute CRET sessions over an 8-week interval. Three months after the last session, the effects of the treatment were trichoscopically analysed. DPC were CRET stimulated intermittently for 12, 24 or 48 h and the effects on cell proliferation and expression of several proteins involved in cell proliferation were analysed.

Results: Trichoscopic data revealed generalized, statistically significant hair redensification (10 – 15 % over pre-treatment values) in all the treated scalp areas. In-vitro electrostimulation significantly increased DPC proliferation and expression of the proteins involved in cell proliferation. Since dysregulation of DPC proliferation is the main factor underlying abnormal hair loss, it is likely that electrically-induced DPC proliferation is involved in the redensifying effects obtained in the trichological study.

Conclusion: The results of the trichological study in FPHL patients and those of the experimental study in woman’s DPC are consistent with each other and suggest that 448-kHz CRET could be effective both for hair redensification and hair loss prevention.
Kritická teorie v kontextu informačních a komunikačních technologií a velkých dat
Authors: Rakowski Roman
Published: June 2022

The study analyzes the theory presented in the book Critical Theory and Social Media: Between Emancipation and Commodification by Thomas Allmer. The primary goal of the study is to place this work in the broader context of the critical theory of technology. The first part analyzes the context and the requirement for the philosophy of technology in the current digital age. Subsequently, Allmer’s methodology is described as an offshoot of critical theory. This theory is set in the context of the book’s primary sources of thought, especially the critical theory of technology and Andrew Feenberg’s theory. Based on this theoretical understanding, research areas in critical media and technology theory are defined. The critical theory of technology shows that in the society of big data, there are similar contradictions of capitalism as we can find in the material world. Finally, there requirement for a political theory of technology is theorized, contrary to the widespread view that the current contradictions of digital capitalism can be solved by the ethics (design) of new technologies. In this context, critical theory is compared with the – so-called – ethics of new technologies.
Comparison of Diagnostic Accuracy of CT scan and USG in Right Upper Quadrant Pain: A Review Analysis
Authors:   Mayo Hospital, Lahore, Maryam Laiba
Published: June 2022

Purpose: Acute right upper quadrant (RUQ) pain is a common presenting symptom in emergency departments and outpatient medical practices, and is most commonly attributable to biliary and hepatic pathology. The main objective of the study is to systematically analyse the comparison of diagnostic accuracy of ultrasound and computed tomography in right upper quadrant pain. Material and methods: This study was conducted using a systematic search on Google scholar, Pubmed and Web of science published until 20th June 2020. The cited references of retrieved articles and previous reviews were also manually checked to identify any additional eligible studies with indexed search terms for cholecystitis, US, cholescintigraphy, CT, and MR imaging. Results: After excluding duplicates and articles that did not meet the inclusion criteria, we obtained 30 articles with full-texts which were read for further evaluation, where another 60 were excluded as irrelevant. Overall, we included 30 articles that directly match on the inclusion criteria. Conclusion: It is concluded that RUQ pain were not as good as sensitivities reported in prior studies. CT was statistically significantly better for the diagnosis of RUQ pain than US, most likely because of an unclear clinical picture, the patient population, and a high proportion of poor-quality US examinations. However, US is still our first test of choice if RUQ pain is suspected clinically, whereas CT is performed when the clinical picture is unclear.
Comparing Different Permutation Tests with Dickey-Fuller Tests for Unit Toot in the Autoregressive Time Series
Authors: Li Jiexiang
Published: June 2022

Abstract
Three permutation tests based Tn (Li et al. (2013)), KSn and BKRn (Blum et
al.(1961)) for unit root in the AR(1) time series are investigated and compared to
Dickey-Fuller tests with white noise from distributions at different levels of skewness
(symmetric distributions such as standard normal; slightly skewed distributions
such as Chisq (1); highly right skewed distributions such as Weibull (shape=1/3,
scale=1); highly left skewed distributions such as negative lognormal (µ = 0, σ = 2))
and two moderately skewed F distributions with numerator degree of freedom 1
and denominator degrees of freedom 7 and 4. As expected, Dickey-Fuller tests
overperform the permutation tests when white noise is from symmetric distributions
or slightly skewed distributions. The permutation tests based on BKRn perform
at least comparable to and most of the time overperform the permutation tests
based on KSn regardless of the levels of skewness of white noise distributions. The
permutation tests based on Tn could not compare to Dickey-Fuller tests when white
noise is from symmetric distributions and it could not compare to the permutation
tests based on BKRn when white noise is from skewed distributions.

JEL classification numbers: C12, C14, C15.
Keywords: Permutation tests, Autoregressive, Unit root.
LINGUISTAS ESTRUTURALISTAS:
Authors: Benicio de Andrade Dias Juliana , Pereira de Carvalho Gleyce , Gonçalves de Andrade Moreira Raissa , Lopez Estivalet Gustavo
Published: June 2022

O presente trabalho apresenta uma relação de linguistas importantes para o estruturalismo. Ao estudarmos essa teoria, percebemos que os mesmos autores são permanentemente citados, como Saussure e Bloomfield. Contudo, ao investigarmos de forma direcionada os linguistas que contribuíram para o desenvolvimento do estruturalismo, percebemos que diversos outros nomes complementam os estudos linguísticos para o desenvolvimento desta abordagem. Portanto, nosso objetivo principal foi apresentar um compilado dos principais autores estruturalistas e, como objetivos específicos, nosso trabalho pretendeu i) organizar cronologicamente os linguistas estruturalistas, ii) apresentar brevemente suas biografias, iii) pontuar suas principais contribuições para a linguística e iv) introduzir autores estruturalistas pouco (re)conhecidos. Dito isso, a metodologia deste trabalho está organizada em quatro etapas: pesquisa prévia dos autores, organização por local de trabalho, cronologia de publicação e discussão sobre suas contribuições. Como resultados, obtivemos uma lista com 25 linguistas estruturalistas, suas biografias e principais contribuições para a linguística.
AVALIAÇÃO E PERCEPÇÃO DAS FORMAS NÓS E A GENTE E DOS PADRÕES DE CONCORDÂNCIA POR FALANTES ESCOLARIZADOS DE FORTALEZA - CEARÁ
Authors: Freitas Maylle Lima , Favacho Larissa de Lima , Macedo de Carvalho Hebe
Published: June 2022

Este estudo investiga a avaliação e percepção da alternância de nós e a gente e a concordância verbal com essas formas pronominais por participantes escolarizados de Fortaleza/CE. Parte da premissa laboviana (LABOV, 2008 [1972]) de que os falantes atribuem valores e julgamentos às variantes linguísticas, sendo esses valores passíveis de mensuração em testes de reação subjetiva. Foram elaborados e aplicados formulários de percepção e avaliação linguística inspirados em Eckert (2008), Campbell-Kibler (2009) e Oushiro (2015) para a investigação dos significados sociais atribuídos às variantes. Os formulários foram aplicados e disponibilizados pela plataforma Google forms, divulgados nas redes sociais WhatsApp, Telegram, Facebook, Instagram e Twitter e compartilhados entre amigos de amigos. Os resultados estatísticos foram computados pela plataforma RStudio para a geração de frequência e proporção das respostas e para a criação da árvore de distâncias mínimas (OUSHIRO, 2019). As formas nós e a gente com concordância recebem avaliação positiva, sendo o nós associado a prestígio-escolarização-bairros centrais, e a gente a informalidade-periferia urbana. A variante inovadora (a gente) não sofre estigma pelos participantes escolarizados de Fortaleza, no entanto os ouvintes associam a ausência de concordância (nós sem -mos) a não escolarização, informalidade e uso de periferia urbana.
LITERATURA INFANTIL E VALORES INCLUSIVOS
Authors: Gomes dos Santos Bessa Luiza
Published: June 2022

Este artigo tem como propósito discutir a importância da literatura infantil para o desenvolvimento social, cognitivo, emocional e afetivo da criança, bem como observar de que forma essa literatura pode ser usada para construção de valores como a aceitação, o respeito, o acolhimento e a empatia enquanto sujeito de uma sociedade multicultural. Demanda também verificar como as histórias infantis, elaboradas de forma lúdica, abrem leques de oportunidades para expor temas delicados e conflituosos como: deficiências físicas, preconceito racial, exclusão, bullying, etc. A problemática será analisada a partir de duas obras direcionadas ao público infantil que trazem reflexões significativas sobre a inclusão, são elas: O coelho sem orelhas de Til Schweiger e Klaus Baumgart e Tudo Bem Ser Diferente, de Todd Parr, que abordam a temática de forma ampla e divertida, visando uma convivência mais tolerante na sociedade.
JORGE MEDAUAR E ADONIAS FILHO:
Authors: Santos França Ítalo Yan , Silva Cristiano Augusto da
Published: June 2022

O artigo possui como hipótese de trabalho a ideia de que as narrativas nos livros Água Preta (1958), de Jorge Medauar, e Corpo vivo (1962), de Adonias Filho, são representações profundamente divergentes quanto às relações sociais no espaço sul-baiano, divergências percebidas na presença do narrador e na apresentação das personagens. O objetivo principal é compreender o ponto de vista dos narradores no que se refere às relações de poder na região sul-baiana. Para tanto, fez-se necessário analisar o romance Corpo vivo em sua individualidade, a partir da leitura de uma violência alienante, que intenta ser “trágica”. No caso de Água Preta, procura-se compreender os contos ”Jagunços”, “O pontilhão” e “Esperança” a partir da ótica do narrador descentrado (GINZBURG, 2012) e da representação da melancolia na trama (GINZBURG, 2013). Nessa perspectiva, o referencial teórico está composto de estudos sobre o ponto de vista na ficção (FRIEDMAN, 2002; GINZBURG, 2012) bem como trabalhos acerca da violência e relações de poder (BENJAMIN, 1986; ELIAS; SCOTSON, 2000; GINZBURG, 2013).
CONCEPTUALIZAÇÃO DO NOVO CORONAVÍRUS EM MEMES MULTIMODAIS DE REDES SOCIAIS:
Authors: Costa Rios Jonedson
Published: June 2022

Neste artigo, apresentam-se resultados obtidos mediante um estudo acerca das conceptualizações metafóricas e metonímicas do novo coronavírus em memes multimodais publicados em redes sociais, como Twitter e Facebook. Para a realização do estudo, foram utilizados os pressupostos teóricos da Linguística Cognitiva, principalmente da subárea Semântica Cognitiva, e foram feitos diálogos com autores como Lakoff e Johnson (2002), Sánchez (2009), Soriano (2012), Andrade (2016), Almeida (2020), entre outros. Sendo assim, a pesquisa partiu de uma revisão bibliográfica e de técnicas metodológicas da área, e realizou, por fim, discussões sobre as metáforas e metonímias conceptuais acionadas a partir do corpus, bem como os domínios experienciais envolvidos nesses processamentos.
The role of cytochromes CYP1A and CYP3A in the genotoxic effect of benzo(a)pyrene
Authors: Malygina Daria Alexandrovna , Rogovskaya Nadezhda Yurievna , Beltyukov Petr Petrovich , Babakov V. N.
Published: June 2022

Introduction. Benzo(a)pyrene metabolites are genotoxic compounds, the accumulation of which contributes to carcinogenesis. The main mechanism of metabolite formation is the benzo(a)pyrene oxidation by cytochromes P450 (CYP). Inhibitors of the main cytochromes can reduce the rate of metabolite formation and, as a result, to decrease the genotoxic effects of benzo(a)pyrene metabolites. In contrast, inducers of cytochromes contribute to the enhancement of genotoxicity. Objective. The aim of the work was to develop a cell model based on the HepaRG cells to study the role of cytochromes activity in the genotoxic effect of benzo (a) pyrene. Material and methods. To assess the effect of inhibitors of cytochromes CYP3A and CYP1A on the genotoxic effect of benzo(a)pyrene in HepaRG cells, the content of active forms of proteins of the DNA damage detection and repair system, phosphorylated forms of signaling cascade proteins was determined by immunoassay using Luminex xMAP technology. The cytotoxicity of benzo(a)pyrene was assessed by real-time cell analysis on xCelligence analyzer. Results. Inhibitors of CYP3A and CYP1A cytochromes, ketoconazole and α-naphthoflavone demonstrate the ability to diminish the toxic effects of benz (a) pyrene, reduce the activation of the DNA repair system, and have a multidirectional effect on the different tyrosine kinases phosphorylation in signaling pathways. Conclusion. HepaRG human hepatoma cells are a suitable cell model both to assess the contribution of cytochromes to the metabolism of xenobiotics and to study of the cell protection from the genotoxic effect of benzo (a) pyrene by cytochrome inhibitors. Limitations. The study was performed on a cell culture. To extrapolate the data to the organism, it is necessary to take into account the data of toxicodynamics and toxicokinetics.
Experimental substantiation of the tentatively safe level of diethyl disulfide in the air of the working area and the atmospheric air of populated areas
Authors: Kucherskoy Semen Alexandrovich , Alikbaeva Liliya Anatolievna , Karmanov Evgenii Yrievich , Ermakova Irina Borisovna , Oskina Diana Gaevna , Radilov Andrej Stanislavovich
Published: June 2022

Introduction. Diethyl disulfide belongs to the group of dialkyl disulfides, is a part of disulfide oil and a mixture of dialkyl disulfides. As a result of industrial purification of hydrocarbon raw materials from mercaptans, tens of thousands of tons of dialkyldisulfides and their mixtures are accumulated annually, the toxicity and danger of which have not been fully studied. No hygiene standards have been developed for diethyl disulfide. Materials and methods. Studies of the effects of diethyl disulfide were carried out in non-linear animals (rats and mice). The toxic properties of diethyl disulfide were studied under the conditions of single and repeated exposure to the intragastric, intraperitoneal, inhalation and cutaneous routes of entry into the body. Results. Based on the studies carried out, the toxicometric parameters of diethyl disulfide were established. Average lethal dose with intragastric administration LD50 = 1575 mg/kg, average lethal concentration CL50 = 18700 mg/m3, coefficient of possible inhalation poisoning CPIP = 1.3, limit of acute inhalation action (Limac) is set at 120 mg/m3, acute zone Zac = 156, cumulation coefficient was 3.2. Diethyl disulfide does not have a skin-resorptive toxic effect, but it has a moderately pronounced irritating effect on the mucous membrane of the eyes. Limitations of the study. The results of the diethyl disulfide exposure assessment are given for two animal species and four main routes of entry. Conclusion. The data obtained indicate that diethyl disulfide is a moderately hazardous substance with a single intragastric, inhalation and cutaneous route of entry into the body. The cumulative properties of diethyl disulfide are moderately expressed. Based on the analysis of literature data, the results of experimental studies and mathematical forecasting, a value of 4.0 mg/m3 is recommended as an approximate safe level of exposure in the air of the working area, in the atmospheric air of urban and rural settlements - 0.04 mg/m3.
Asociatividad empresarial como alternativa para el éxito competitivo de las MIPYMES en Costa Rica
Authors: Salas  León Carlos
Published: June 2022

Dado el insuficiente conocimiento documentado sobre los factores que inciden en la asociatividad empresarial y cómo ésta puede afectar positivamente la posición competitiva de las MIPYMES, existe una gran necesidad por conocer más a fondo su potencial para contribuir con la competitividad y la sostenibilidad de los grupos empresariales. El método de investigación seguido toma en cuenta proyectos asociativos que se encuentran ubicados geográficamente en Costa Rica, para lo cual se siguió un esquema de investigación mixto (cualitativo-cuantitativo), con revisión de fuentes secundarias existentes y obtención de información primaria mediante el método estadístico de proporciones para poblaciones finitas. Esta investigación contribuye con el estado del conocimiento acerca de los motivos que influyen en las MIPYMES de Costa Rica para asociarse y las condiciones de apoyo para que esos grupos asociativos lleguen a ser exitosos. El éxito competitivo de los grupos empresariales depende de una serie de factores que involucra tanto aspectos intrínsecos (aquellos propios e internos de las asociaciones de MIPYMES, tales como las ventajas competitivas grupales alcanzadas por la asociación), como aspectos extrínsecos (aquellos externos o propios del entorno de las asociaciones). Las relaciones de confianza, el liderazgo de los integrantes y los beneficios percibidos por éstos, emergen como los principales factores identificados.
La Gestión Ambiental en la Sede Interuniversitaria de Alajuela a través del Equipo Asesor Ambiental y el Programa Galardón Ambiental
Authors: Ruiz Siles Yanina , Acuña Acosta Enrique
Published: June 2022

La investigación ha evidenciado que, pese a las diferencias administrativas de las distintas universidades estatales, el Equipo Asesor Ambiental (EAA) ha logrado una participación y colaboración interuniversitaria en materia ambiental, permitiendo procesos de innovación en dicha área. Este estudio pretende analizar el quehacer del EAA y su gestión ambiental en la Sede Interuniversitaria de Alajuela (SIA), generando datos que permitan replicar esta relación en otros espacios. Debido a la naturaleza mixta de esta indagación, se optó por centrarse en el programa Galardón Ambiental, lo que permitió profundizar sobre este proceso. La información se recopiló de fuentes oficiales, como el EAA y la Universidad de Costa Rica (UCR). Se determinó que la integración de diversas entidades y de la comunidad cumplen un rol fundamental en la gestión ambiental. Los avances de la SIA-UCR han contribuido al desarrollo de nuevos proyectos, asimismo otros se han adaptado a las especificidades de la SIA y del contexto. Una investigación de este tipo de nexos resulta estratégica, pues permite entender y reflexionar sobre el papel que podrían desempeñar los programas de gestión ambiental en diferentes ámbitos.
Xalqaro baholash dasturlarida moliyaviy savodxonlikni aniqlashning ahamiyati
Authors: Yusupova Shahzoda
Published: June 2022

Ushbu maqola O‘zbekiston va jahon hamjamiyati aholisining moliyaviy savodxonligini baholashda qo‘llaniladigan ma’lumot-larni tahlil qilish usullariga qaratilgan. Xususan, baholash dasturlarining moliyaviy savodxonligini aniqlash uchun foyda-laniladigan ma’lumotlar hamda tahlil qilingan yondashuvlarini moliyaviy savodxonlikning ta’lim ehtiyojlarini maqsadli tarzda qamrab olish ahamiyatini ko‘rib chiqishga harakat qilamiz.
SATELLITE IMAGE PROCESSING AND HEADS-UP DIGITIZATION METHOD FOR THE ASSESSMENT OF WATERBODY ENCROACHMENT USING GEOSPATIAL TECHNOLOGY
Authors: K Anitha
Published: June 2022

Water bodies like lakes or tanks or ponds play a significant role in preserving and restoring the ecological stability. They are in existence for several centuries, serving the water needs of communities. Encroachment of water bodies for development human settlements and farming has been increased due to population growth and public attitude. This research focused on the water bodies encroachment in Manapparai Taluk, which covers an area of 1090 sq.km that encompasses 108 revenue villages and located in the central part of Tamil Nadu, India. The remote sensing techniques were used to assess the land-use land cover (LULC) changes, The visual interpretation techniques were used to prepare the LULC map and investigated the changes between topographic sheets of 1976 and Quick Bird satellite imagery of 2019. The vector layers of LULC were created by using heads-up digitization method in open-source geospatial software environment i.e. QGIS and GRASS. The LULC changes were assessed according to revenue villages, also predicted the total number of water bodies encroached by the public. The results of LULC layers between 1976 and 2019 confirm that the extent of human settlement increased from 3.52% to 5.98% of the total area, while vegetation cover also increases from 1.38% to 2.12%. Besides, the lakes and ponds decreased from 4.11% (44.94 sq.km) to 3.82 % (39.14 sq.km). The research has demonstrated the advantages of QuickBird satellite imagery to provide an exact, cost-effective contribution to prepare a map and investigate LULC changes over an interval.
Case Report: Pulmonary Tuberculosis Reactivation in Patients with Human Immunodeficiency Virus: A Case Report
Authors: Hogea Elena , Manolescu Diana-Luminita , Muntean Alexandra-Cristina , Teoteoi-Popa Madalina-Amalia , Moisil Teodora , Bica Mihai-Calin , Pilut Ciprian-Nicolae , Miclau Andreea-Maria , Oancea Cristian-Iulian , Bujor Georgeta-Cristiana
Published: June 2022

We present one case of co-infection with Mycobacterium tuberculosis (MTB) in a patient with Human Immunodeficiency Virus (HIV). It`s a case of a 27-year-old woman admitted at the Clinical Hospital of Infectious Disease and Pneumology ”Dr. Victor Babeș” Timișoara. The patient was known to be HIV-positive since 2019 and developed pulmonary tuberculosis during the therapy. The patient was non-compliant at antiretroviral therapy and developed pulmonary tuberculosis first time in December 2020. One year later, the same patient was admitted in the hospital with pulmonary manifestations and a reactivation of pulmonary tuberculosis was once again confirmed.
In Memoriam: Robert Killick-Kendrick
Authors: Hamarsheh Omar
Published: June 2022

Robert Killick-Kendrick was born on 29 June 1929, Hampton, UK. He is a dedicated and outstanding parasitologist specialized in infectious diseases and tropical medicine, particularly in the parasites that cause diseases in humans and other mammals, including malaria, African trypanosomiasis (sleeping sickness) and leishmaniasis. His early research was on African trypanosomiasis and malaria. In 1972, he set up a research unit at Imperial College funded by the Wellcome Trust and the Medical Research Council of the United Kingdom to study leishmaniasis and phlebotomine sandflies. He joined the London School of Hygiene and Tropical Medicine in 1949 as a laboratory assistant, on 1963 He joined the London School to continue research on malaria parasites (Lainson et al. 2011). Bob extended his interest into leishmaniasis disease in Latin America, Middle East and southern France, where he collaborating with Professor Rioux at the University of Montpellier, France. Bob married with Mireille Bailly; a sand fly specialist gaining much more interest in the study of Leishmania vectors. His major wok in Monpellier was concentrated.on the eco-epidemiology of L. (L.) infantum and role of Phlebotomus ariasi as the vector of visceral leishmaniasis in France and neighboring countries, resulted in a number of research papers concerning the sand fly-parasite relationship, mechanism of sand fly bite transmission, ecology and wind dispersal, sugars meals of the sand flies from plants and "honey-dew" from aphids. He has invaluable contribution in sand fly control demonstrating the effectiveness of insecticide impregnated dog collars in killing or repelling sand fly vectors attempting to bite the major, canine reservoir host of L. infantum (Rioux et al. 2012). During his scientific life, he authored/coauthored 300 research papers and several specialized books in infectious diseases.