bluuebunny/crossref_metadata_2025 huggingface dataset:
Klasterisasi Manajemen Perkandangan Sapi Bali pada Simantri di Kabupaten Badung
Authors: Suputra Gusde Wahyu Krisna , Sampurna I Putu , Nindhia Tjok Sari , Agustina Kadek Karang
Published: September 2019

Penelitian klasterisasi manajemen perkandangan sapi bali pada sistem pertanian terintegrasi (Simantri) di Kabupaten Badung, bertujuan untuk mengetahui komponen-komponen perkandangan sapi bali yang belum dilakukan secara intensif pada gabungan kelompok tani (Gapoktan) di Kabupaten Badung dan untuk mengetahui Gapoktan mana yang belum melakukan sitem perkandangan sapi bali secara intensif pada Simantri di Kabupaten Badung. Pengambilan sampel manajemen perkandangan sapi bali dilakukan secara teknik sampling jenuh. Data yang diperoleh dianalisis menggunakan Hierarchical cluster dengan Plot dendogram cluster dengan variabel penciri intensif, semi intensif, dan ekstensif. Hasil dari penelitian ini 42 dari 50 Simantri pada Gapoktan di Kabupaten Badung sudah menerapkan manajemen perkadangan secara intensif, komponen manajemen perkandangan yang sebagian besar dilakukan secara intensif meliputi: atap kandang, tempat pakan, tempat minum, lantai kandang, keadaan sekitar kandang, dan pembersihan kandang. Ada delapan Simantri yang manajemen perkandangan masih semi intensif. Komponen manajemen perkandangan yang masih diterapkan secara semi intensif adalah kebersihan kandang. Perlu dilakukan penyuluhan kepada anggota Simantri untuk membenahi manajemen permbersihan kandang
THE PHENOTYPIC PERFORMANCE OF KAMBRO CROSSBREEDS OF FEMALE BROILER COBB 500 AND MALE PELUNG BLIRIK HITAM
Authors: Mahardhika I Wayan Swarautama , Daryono Budi Setiadi
Published: September 2019

This research was conducted to measure the phenotypic performance of Kambro crossbreeds of Pelung Blirik Hitam and Broiler Cobb 500. Based on Body Weight (BT) measurement, Kambro population (n = 17) has an average BT of 1,244.14 ± 453.82 grams significant (p <0.01) to F1 Pelung (n = 7) with an average BT of 602.88 ± 79.93 grams in 8 weeks period with ad libitum diet of standard feed. Phenotypic performance of Kambro significant to F1 Pelung based on the measurement of linear bodyweight parameter, vitality parameter, PPa-PBe parameter and phenotype parameter. Kambro has the phenotype combination of parental generation based on phenotype parameter. PPa parameter was suitable BT estimation model based on non-linear quadratic regression (r = 0.956) with formula 1.84E3 ±3.54E2*x+31.73*x2. Difference between chicken group (p<0.014) was significant to BT and interaction between group and linear bodyweight parameter was not significant based on Analysis of Covariance. The mortality rate of Kambro was lower than F1 Pelung with the absent of vaccination in semi-intensive rearing system. As the size of hybrids population was limited, research findings must be validated with larger population size of hybrids.
Kesembuhan Fraktur Tulang Femur Kelinci Pasca Implantasi Bahan Cangkok Demineralisasi Serbuk Tulang Sapi Bali
Authors: Asih Ni Putu Trisna , Wirata I Wayan , Sudimartini Luh Made , Winaya Ida Bagus Oka , Kardena I Made , Gorda I Wayan
Published: September 2019

Tujuan penelitian ini untuk mengetahui gambaran mikroskopis kesembuhan fraktur tulang femur kelinci pascaimplantasi dengan bahan cangkok demineralisasi serbuk tulang sapi bali. Kelinci lokal jantan  sebanyak 12 ekor digunakan dalam penelitian ini yang dibagi menjadi dua kelompok secara acak. Kelompok A adalah tiga ekor kelinci yang digunakan sebagai kontrol, yaitu kelinci pada diaphysis tulang femurnya dibor dengan diameter 5 mm dan kedalaman bor hingga mencapai medula, tanpa pemberian bahan cangkok. Kelompok B adalah 9 ekor kelinci yang dibor seperti kelompok A dan diberikan serbuk cangkok tulang pada bagian tulang yang dibor. Pada minggu ke-2, ke-4, dan ke-6 pascaoperasi dilakukan biopsi tulang masing-masing satu ekor kelinci pada kelompok A dan tiga ekor kelinci pada kelompok B.  Pengamatan mikroskopis dilakukan dengan membuat sediaan tulang  diwarnai dengan Hematoksilin-Eosin (HE). Hasil penelitian menunjukkan bahwa proses kesembuhan tulang lebih cepat terjadi pada kelompok B yang diamati dari minggu ke-2 sampai minggu ke-6 dengan sel radang terlihat sedikit dan jumlahnya berkurang setiap pengamatan, adanya pertumbuhan osteoblas, osteoklas, osteosit, kartilago, tulang trabekula, neovaskularisasi dan proliferasi fibrolas lebih cepat dibandingkan kelompok A. Dapat disimpulkan, bahan cangkok asal tulang sapi bali mampu menginduksi proses kesembuhan tulang fraktur pada kelinci.
Penentuan Kadar Protein dan Fraksi Protein Crude Antigen Cysticercus cellulosae dari Isolat Lokal
Authors: Nugraha Leksana Aditya Kris , Swacita Ida Bagus Ngurah , Apsari Ida Ayu Pasti
Published: September 2019

Sistiserkosis merupakan penyakit parasitik yang disebabkan oleh larva cacing pita yang disebut Cysticercus. Cysticercus yang ditemukan pada babi adalah Cysticercus cellulosae yang merupakan larva dari cacing pita Taenia solium. Tujuan penelitian ini adalah untuk mengetahui kadar dan fraksi protein Crude antigen C. cellulosae. C. cellulosae yang digunakan adalah isolat lokal yang diperoleh dari babi terinfeksi yang berasal dari Karangasem – Bali. Penentuan kadar protein larva dilakukan dengan menggunakan alat Invitrogen Quibit Fluorometer dan penentuan fraksi protein larva dengan teknik elektroforesis menggunakan SDS-PAGE. Hasil penelitian menunjukan bahwa kadar protein C. cellulosae isolat lokal sebesar 867 µg/ml. Sedangkan untuk fraksinasi protein larva diperoleh 6 bands protein dengan berat molekul:  bands 1 = 120,5 kDa, bands 2 = 99,8 kDa, bands 3 = 60,8 kDa, bands 4 = 47,7 kDa, bands 5 = 35,6 kDa, dan bands 6 = 23,3 kDa.
DETECTION AND SEQUENCING GENES IRON, IUTA, AND HLYF IN AVIAN PATHOGENIC ESCHERICIA COLI
Authors: Ramaditya Nyoman Anandiya , Besung I Nengah Kerta , Mahardika I Gusti Ngurah Kade
Published: September 2019

Research has been carried out to detect pathogenic gene markers of Avian Pathogenic Eschericia coli (APEC) iroN, iutA, and hlyF in Escherichia coli bacteria isolated from organs of sick chickens in Bali, and to determine phylogenetic relationships between those marker genes in Bali and in the other countries in the world. Six isolates of E. coli bacteria with codes E2, E3, E7, E8, E9, and E10 were used in this study. The isolates were isolated from domestic chicken in 2018. All genes were detected using the Polymerase Chain Reaction (PCR) method. The genes of iroN, iutA, and hlyF could be detected from all isolates. Well readable sequence of iroN, hlyF, and iutA was 659 bp, 518 bp, and 250 bp, respectively. All three genes were homogenous. Phylogical analysis shows that all pathogenic markers share same cluster with the pathogenic E. coli from all countries in the world.
Reaksi Pasar Terhadap Pelemahan Nilai Rupiah Pada Nilai Tukar US Dollar
Authors: Putra R. Egi Pradnya , Wirawati Ni Gusti Putu
Published: September 2019

The sampling method used was purposive sampling with a total sample of 39 companies from the LQ45 stock index for the period February-July 2018. The data analysis technique used paired sample t-test with a significance level of 5% on normal distributed data and the Wilcoxon test on data not normal distribution. This study produces a significant difference between the abnormal return and trading volume activity before and after the weakening of the rupiah value on the US Dollar exchange rate against the LQ45 company stock listed on the IDX. The results of this study support the theory of market efficiency where the market responds to incoming information, and how that information can further influence the movement of securities prices towards new equilibrium prices.

Keywords: Market reaction, event study, weakening rupiah value, abnormal return, trading volume activity.
Pengaruh Penerapan E-Filling Pada Kepatuhan WPOP Pegawai Negeri Sipil Dengan Pemahaman Internet Sebagai Variabel Pemoderasi
Authors: Putra Agniveda I Gusti Ngurah Agung , Supadmi Ni Luh
Published: September 2019

This study aims to determine the effect of the application of e-filling on the compliance of the civil servant taxpayers with an understanding of the internet as a moderating variable in the East Denpasar Primary Tax Office. The number of samples used in this study were 100 respondents out of 16,732 effective civil servant populations in East Denpasar Primary Tax Office. The method of determining the sample used was non-probability sampling with a purposive sampling technique. Data collection in this study was conducted by questionnaire method. The data analysis technique used is the analysis of Moderated Regression Analysis (MRA). The results showed that the application of e-filling had a positive effect on the compliance of the civil servant taxpayers and understanding the internet was not able to moderate the effect of implementing e-filling on the compliance of the civil servant taxpayers at East Denpasar Primary Tax Office.

Keywords: E-filling, understanding of the internet, taxpayers compliance.
Pengaruh Penerapan Akuntansi Pertanggungjawaban, Kompetensi dan Komitmen Organisasi Terhadap Kinerja Manajerial
Authors: Cahyani Kadek Novita , Damayanthi I Gst Ayu Eka
Published: September 2019

Managerial performance is very important for a company because it can be used to measure the success of the company. A manager needs to implement a managerial control system that can be used to achieve the company goals. The purpose of this study is to obtain empirical evidence regarding the effect of applying accountability accounting, competence and organizational commitment to the managerial performance of the financial division on PT Pegadaian Kota Denpasar. Sampling technique that used in this study is non probability sampling with purposive sampling method. The amount of sample in this study are 52 samples. The analysis technique is multiple linear regression. Based on the results of the analysis shows that accountability accounting, competence, and organizational commitment have a positive effect on the managerial performance of financial division on PT. Pegadaian Kota Denpasar.

Keywords : Accountability accounting, competence, organizational commitment, managerial performance.
Pengaruh Komponen Kecerdasan Emosional pada Pemahaman Akuntansi
Authors: Sukma Mutiara Pramita Sari Made , Wirama Dewa Gede
Published: September 2019

Accounting education in college is intended to educate students to work as professional accountants with knowledge in accounting. Understanding of accounting is the process to understand accounting both as knowledge and as a process or practice. Understanding of accounting can be influenced by emotional intelligence of each individual. The purpose of this study is to determine the effect of the components of emotional intelligence on accounting understanding. This research was conducted at the Faculty of Economics and Business, Udayana University. The number of samples was 111 students, using non probability sampling methods. Data collection is conducted through a questionnaire. The data analysis technique used is multiple linear regression analysis. Based on the results of the analysis it was found that the components of emotional intelligence had positive effects on accounting understanding. The higher self-recognition, self-control, motivation, empathy and social skills, the higher the understanding of accounting.

Keywords: Accounting, emotional intelligence, accounting students.
Pengaruh Profitabilitas, Struktur Aset, Likuiditas, Dan Pertumbuhan Penjualan Terhadap Struktur Modal Perusahaan Makanan Dan Minuman
Authors: Gunadhi Gede Bagus Dwiputra , Putra I Made Pande Dwiana
Published: September 2019

The purpose of this research is to understand the effect of profitability, asset structure, liquidity, and sales growth on the capital structure of food and beverage companies listed on the IDX. This research was conducted at 19 food and beverage companies listed on the Indonesia Stock Exchange (IDX) in 2015-2017 by accessing the website www.idx.co.id. The sample used in this study was determined using a non probability sampling method by used purposive sampling technique, so the final sample used in this study amounted to 15 companies. The data collection method used is the nonparticipant observation method. The data analysis technique used is multiple linear regression analysis. The results of this study are that profitability and liquidity have a negative influence on the capital structure, while the asset structure and sales growth have a positive influence on capital structure.

Keywords: Profitability, asset structure, liquidit,  sales growth, capital structure.
Pengaruh Kesadaran, Kualitas Pelayanan, Pengetahuan Perpajakan, Dan Sanksi Perpajakan Pada Kepatuhan Wajib Pajak Reklame
Authors: Permatasari Mirah , Lely Aryani M Ni Ketut
Published: September 2019

Public awareness to comply with taxation obligations  play an important role in tax revenue revenue. This study is intended to determine whether taxpayer awareness, service quality, tax knowledge, and perceptions of tax sanctions have an effect on advertisement taxpayer compliance in the Regional Revenue Board of Badung Regency.. The method of determining the sample in this study using incidental sampling techniques with the number of respondents as many as 54 taxpayers. The data analysis technique used is multiple linear regression analysis. The effect of taxpayer awareness, service quality, tax knowledge and perceptions about tax sanctions on advertisement tax compulsory compliance of 98.3%. The effect of taxpayer awareness on advertisement taxpayer compliance is 1%. The effect of service quality on advertisement taxpayer compliance is 2.2%. Knowledge of taxation on advertisement taxpayer compliance is 4.8%. The influence of taxpayer perceptions about tax sanctions on advertisement taxpayer compliance is 92% .

Keywords: Taxpayer Compliance, Taxpayer Awareness, Service Quality, Tax Knowledge, Taxpayer Perception About Tax Sanctions.
POLA PENGELUARAN WISATAWAN DI BANGKA BELITUNG
Authors: Sitorus Berlian
Published: September 2019

Tourism is the main sectors for driven a sustainable economy through the multiplier impacts of tourism expenditures. However, we don't know yet how much the impact of changes in the structure and the expenditure on income. This paper aims to explore data from Tourism Satellite Account (TSA) in the Province of Bangka Belitung Islands in 2011 and 2017. Results from this study found the increasing 346 percent of tourist spending for increased 200% visitor thus it was concluded that tourism activities had a major impact on income creation. This means that tourism activities in Bangka Belitung have been integrated into the regional economic system and have a tremendous impact on the lives of the people of Bangka Belitung.
WANPRESTASI PERJANJIAN PERJALANAN WISATA LUAR NEGERI OLEH WISATAWAN INDONESIA
Authors: Kusuma Sanjiwani Putri , Kerti Pujani Ni Luh
Published: September 2019

The development of tourism, supported by a breakthrough in the development of industry 4.0, has brought great changes to people in all parts of the world.Tourism is a secondary need for millennial today. They have different motivations individually towards the destination they dream of. People who buy overseas travel packages in travel agents have an escape mode by separating themselves from the tour group at certain destinations.The writing method used in this study is empirical legal research methods supported by primary and secondary data with data collection techniques carried out by observation, interviews, and literature studies.The form of default carried out by Indonesian tourists is classified as doing something in an agreement that is prohibited/ cannot be done.Defaults are made by tourists who will separate themselves from the group and disappear during the tour.They do not return to the hotel or appear within 24 hours so they can be declared lost and reported missing.This activity can broaden the image of the Unitary State of Indonesia in general and the image of travel agents in particular.There needs to be coordination between the community, the government and businessmen of travel agents in suppressing the practices or activities of illegal immigrants.
COMMUNITY-BASED CULTURAL TOURISM AND LOCAL TOURISM IN THE GLOBALIZATION CENTER
Authors: Darmana K.
Published: September 2019

Cultural tourism is an important issue in the global tourism industry, in a global context claimed to distort customs and traditions as local wisdom. The main problem to be answered is (1) What is the form of community-based Using cultural tourism ?, (2) How is the management of the global tourism market management? (3) What is the development strategy in global competition? The purpose of this study is to understand the forms of Using culture tourism, its management techniques, and its development strategies. Qualitative methods to answer the problems and objectives of this study involving a number of informants. Data collection is based on in-depth interview techniques, participatory observation, and document study. Qualitative data analysis through the stages of reduction, categories and classifications, determining themes, and drawing conclusions. The framework of cultural tourism theory in ecotourism, community-based cultural tourism, and management of cultural tourism management support analysis and writing. The results of this study are 2 forms of Using cultural tourism: tangible and intangible tours. Tangible tourist attraction objects are: Using home architecture, Using tourist parks, rice fields, Balai Paseban Buyut Chili, and culinary. Intangible attractions such as Using customs, life cycle ceremonies, and Using art. All forms of tourism are managed by the synergy of three components of Using tourism, namely: Using traditional institutions, Using tourism conscious groups (pokdarwis), and private parties. Using traditional institutions of representation of citizens of the Using community, Pokdarwis representation from the government, and private representation from investors. The form of development strategies such as the accessibility and amenities of tourism by the government, customs, traditions, and Using arts are synergies between local communities and government, marketing and human resources synergy tourism between local, government and private communities. Community and government participation is more dominant in its development. Internet support, and social media networks appear to play a lot in development, especially marketing, promotion, storytelling and service. The issue of conservation, preservation, and sustainability of Using tourism resources, has not been considered development because the economic aspects are the targets and objectives. In the future, the mainstreaming of this aspect is prioritized so that community-based Using cultural tourism and local wisdom can be dynamic in the global era.
Demographic and Clinical Profile of Tuberculous Mastitis Patients at Tebet General Hospital, Jakarta
Authors: Pramegia Desak Ketut Nari Swari , Faried Rio Putratama Achmad , Setiawan Kelvin , Rosadi Bramastha Aires , Lawanto Terry Renata
Published: September 2019

Aim: Objective of the study is to find out the demographic and clinical profile of tuberculous mastitis (TM) patients. Methods: The study was carried out for a period of one year from August 2017 to August 2018 at Tebet General Hospital. Histopathologically diagnosed cases of TM were retrospectively studied. Results: All eight patients diagnosed as suffering from TM were females with the mean age of 37.25 years. Of these, two patients were lactating, six others were not, and 75% were multiparous. Unilateral involvement was observed in all cases. The right breast was affected in 62.5% and left breast in 37.5% cases. Patients presented with a solitary lump on one breast (87.5%), swelling of the breast (37.5%), and breast pain (100%). In the present study, two of the patients had previous positive tuberculosis (TB) contact and more than half found to be below an average economic level. All the patients were negative on the HIV test; also, there was no focus of TB elsewhere in the body. Conclusion: Tuberculosis should be considered as one possible cause of either mastitis or breast abscess. Histopathology examination played an important role in the diagnosis of TM. Standardized sequence for the diagnosis of TM is needed to increase awareness of the disease.
Patterns of Fracture Site and Management of Maxillofacial Trauma Cases in The Department of Trauma and Acute Care Surgery in Sanglah General Hospital
Authors: Wiargitha I Ketut , Wiradana AAGA Anom Arie
Published: September 2019

Aim: To know the patterns of fracture site and management of maxillofacial cases in the Department of Trauma and Acute Care Surgery in Sanglah General Hospital Denpasar Bali. Methods: this is a retrospective study, based on medical record were concluded, samples taken in Sanglah General Hospital from January 2012 to December 2018. All of maxillofacial trauma medical records were taken. The data of age, gender, patterns of fractures site and management were taken and described. Results: There were total of 257 cases of maxillofacial trauma managed in the Department of Trauma and Acute Care Surgery in Sanglah General Hospital. Two-hundred and forty-one medical records of maxillofacial trauma were included in this study. About 16 medical records were excluded due to incomplete medical records and could not be contacted. Mostly cases found in male, aged 18-40 years old. The site of fractures majorly located in the mandible (60.12%). About 48% fractures were identified at symphysis or parasymphysis of mandible, followed by the body and angular of mandible. Open reduction and internal fixation (ORIF) were the gold standard of the treatment (83,73%) followed by Archbarr (16,27%). Conclusion: The most common site of maxillofacial fracture was mandible, specifically at symphysis or parasymphysis part. ORIF miniplate, together with Archbarr and interdental wiring fixation were the most common modality of management.
SPESIASI DAN BIOAVAILABILITAS Pb DAN Cu DALAM TANAH PERTANIAN ORGANIK DI BEDUGUL SERTA KANDUNGAN LOGAM TOTALNYA DALAM SAYUR BROKOLI
Authors: Siaka I M. , Nurcahyani H. , Manuaba I B. P.
Published: September 2019

Bedugul area is a vegetable producing center in Bali that also develops organic farming. This study aimed to determine the bioavailability of Pb and Cu in an organic farm in Bedugul and the content of both metals in broccoli before planting and at harvest. Metal extraction was carried out through wet digestion and its bioavailability was determined by the application of the sequential extraction methods. The measurement of the two metals was accomplished by using AAS. The total Pb content in the organic soils before and after harvesting were found to be 746.102-897.3754 mg/kg and 277.778-328.88217 mg/kg, while Cu were of  93.1212-11-114.3259 mg/kg, and 48,608-92.3708 mg/kg, respectively. The bioavailability of Pb and Cu in soils before planting was different from that of at harvest. Pb metal in organic soil before planting which were readily bioavailable, bioavailable, and nonbioavailable were were found to be (17.80-21.62)%, (44.07-47.65)%, and (30.73-36, 89 )%, while Cu were of (5.02-7.89)%, (55.73-60.57)%, and (32.81-39.25)%, respectively. The total Pb and Cu contents in broccoli were of (27,2968-30,3621) mg/kg and (27,0303-30,0223) mg/kg, respectively.

Keywords: bioavailability, broccoli, organic agriculture soil, Pb and Cu, speciation
KADAR Fe DAN Zn DALAM KRIM KENTAL MANIS KEMASAN KALENG EXPIRE DAN NON EXPIRE MENGGUNAKAN HIDROGEN PEROKSIDA (H2O2) UNTUK DESTRUKSI BASAH SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA)
Authors: Go Putri , Sudiarta I W. , Suarya P.
Published: September 2019

Sweetened condensed milk is generally packaged in a can which is made from iron and zinc. Iron and zinc can have corrosion with the increasing of contact time and changing condition so that they will contaminate the milk. The purpose of this research are to determine the best wet destruction method, find out the effect of adding 30% H2O2 at varied volume in the process of wet destruction, to find out Fe and Zn content in expire and non-expired sweetened condensed milk and to compare the results with the national quality standard. Sample was wet destructed by using variation of 70% HNO3: 30% H2O2 which is 3:0 (method A); 3:0.5 (method B) 3:1 (method C); 3:2 (method D) then the results were measured by using Atomic Absorption Spectrophotometer. Analysis of Fe used standard addition curve method whereas the analysis of Zn used calibration curve method. The results of the analysis showed that the best variation of HNO3:H2O2 in wet destruction method was 3:0.5 for Fe analysis and 3:2 for Zn analysis. The addition of 30% H2O2 at varied volume in wet destruction for Fe analysis gave significantly different results for non-expired sweetened condensed milk but were not significantly different for expired sweetened condensed milk. Whereas, the analysis of Zn gave significantly different results for both non-expired and expired sweetened condensed milk. The metal content in the expired and non-expired sweetened condensed milk which were wet destructed by using the best solvent compotition obtained  0,2759 and 0,7126 mg/kg for Fe and 4,1645 and 2,4367 mg/kg for Zn metal. The Fe and Zn content in the sweetened condensed milk are still below the maximum limit that set by SNI.

Keywords: Fe, H2O2, Atomic Absorption Spectrophotometer, sweetened condensed milk, Zn
AKTIVITAS DARI KUERSETIN SEBAGAI AGEN PENCERAH KULIT SECARA IN SILICO
Authors: Adnyani K. D. , Lestari L. W. E. , Prabowo H. , Siaka P. A. I. A. , Laksmiani N. P. L.
Published: September 2019

Increasing melanogenesis process causes excessive melanin synthesis resulting in darkening of the skin color. The melanogenesis process requires mealnogenesis enzymes, one of which is tyrosinase-related protein 1. One of the flavonoid compounds that has the potential as a skin lightening agent is quercetin. The antioxidant activity of quercetin plays a very important role in antimelanogenesis. This study aims to determine the affinity and molecular mechanism of quercetin on the target protein tyrosinase-related protein 1 using in silico molecular docking method. Molecular docking is carried out through stages including optimization of the structure of quercetin compounds, preparation of the target protein tyrosinase-related protein 1, validation of the molecular docking method, and docking of quercetin on the tyrosinase-related protein 1. Docking of quercetin with tyrosinase-related protein 1 produces binding energy values of -7.81 kcal/mol, while docking of native ligand with tyrosinase-related protein 1 produces binding energy values of -5.39 kcal/mol. Quercetin has a strong affinity for tyrosinase-related protein 1 which is indicated by the binding energy from the docking results. Quercetin has activity as a skin whitening agent with in silico test with molecular mechanisms through inhibition of the activity of tyrosinase-related protein 1 enzyme. 

Keywords: skin whitening agent, in silico, quercetin, tyrosinase-related protein 1
MOLECULAR DOCKING TERPINEN-4-OL SEBAGAI ANTIINFLAMASI PADA ATEROSKLEROSIS SECARA IN SILICO
Authors: Susanti N. M. P. , Laksmiani N. P. L. , Noviyanti N. K. M. , Arianti K. M. , Duantara I K.
Published: September 2019

Atherosclerosis is a chronic inflammatory disease that begins with endothelial dysfunction, it caused fat accumulation and plaque growth in the inner arteries walls. Endothelial dysfunction will activate the Mitogen Activated Protein Kinase (MAPK) pathway involving ERK1, ERK2, JNK1, JNK2, and p38MAPK proteins, as well as the Nuclear Factor Kappa B (NF-kB) pathway involving IKK proteins. Terpinen-4-ol is constituent found in the bangle rhizome. The purpose of this study were to determine the affinity and mechanisms of terpinen-4-ol against ERK1, ERK2, JNK1, JNK2, and p38MAPK proteins as anti-inflammatory in atherosclerosis performed using molecular docking method. The study was conducted exploratively with several steps such as preparation and optimization of terpinen-4-ol structure, preparation of 3D ERK1, ERK2, JNK1, JNK2, and p38MAPK proteins, validation method of molecular docking, and docking terpinen-4-ol in these proteins. The docking result are assessed from the binding energy and hydrogen bonds formed between terpinen-4-ol and proteins. The smaller value of binding energy terpinen-4-ol with target proteins showed the complex that form more stable. The result showed that terpinen-4-ol and has activity in inhibiting the inflammatory process because it is able to disturb ERK1, ERK2, JNK1, JNK2, and p38MAPK proteins with respective bond energy values -5,12; -5,24; -5,08; -5,88; and -4,99 Kcal/mol. The molecular mechanism in inhibiting the activity of ERK1, ERK2, JNK1, JNK2, and p38MAPK proteins is through the formation of hydrogen bonds in these proteins. These results show that terpinen-4-ol have the potential to inhibit inflammatory process and the formation of atherosclerotic plaque can be obstructed.

Keywords : atherosclerosis, terpinen-4-ol, molecular docking, in silico
SGLT-2 INHIBITOR: PILIHAN TERAPI BARU UNTUK PENDERITA DIABETES MELITUS TIPE 2
Authors: AMANDARI EKAJAYA
Published: September 2019

Penyakit diabetes melitus tipe 2 (DMT2) merupakan suatu kondisi medis yang ditandai dengan adanya peningkatan kadar glukosa darah melebihi batas normal. World Health Organization (WHO) menyebutkan bahwa jumlah penderita DM di Indonesia mengalami peningkatan dari 8,4 juta penderita pada tahun 2000 menjadi 21,3 juta penderita pada tahun 2030, dimana 90% diantaranya merupakan penderita DMT2. Patofisiologi dari penyakit DMT2 adalah suatu proses yang kompleks dan melibatkan banyak faktor. Konsep ominous octet yang dikemukakan oleh Ralph DeFronzo memegang peranan penting untuk menjelaskan patofisiologi dari DMT2. Ginjal merupakan organ yang memiliki peran signifikan untuk mengendalikan glukosa darah agar tetap dalam batas yang normal, sehingga dipertimbangkan untuk menjadi target terapi obat baru. Sodium  glucose co-transporters (SGLTs) diantaranya SGLT-2 memfasilitasi reabsorbsi glukosa kedalam plasma. Farmakokinetika dari SGLT-2 inhibitor secara umum menunjukkan bioavailabilitas yang baik saat diberikan melalui oral. Diabetes melitus merupakan faktor risiko terjadinya penyakit ginjal kronik (PGK) dan penyakit kardiovaskuler (PKV). Adanya mekanisme penghambatan pada SGLT-2 akan memberikan manfaat terhadap sistem reno-kardiovaskuler melalui penurunan glukosa darah, berat badan, dan tekanan darah. Penghambat SGLT-2 memiliki beberapa efek tambahan yang menguntungkan untuk sindrom metabolik, seperti penurunan berat badan, penurunan tekanan darah (terutama sistolik), serta penurunan asam urat serum
STANDARISASI SPESIFIK DAN NON-SPESIFIK SIMPLISIA DAN EKSTRAK ETANOL RIMPANG KUNYIT (Curcuma domestica Val.)
Authors: Cahya Dayu , Prabowo Heny
Published: September 2019

Turmeric is a plant that included in Zingiberaceae. Turmerics often used as a traditional medicine to heal wounds, antibacterial, reduces intestine motility, reduce unpleasant body odor, treats fever, diarrhea, and many more. Standardization is performed by examining turmeric rhizome simpicia and extract. Standardization is carried out to guarantee the quality of traditional raw materials and requirements for reproducibility of pharmaceutical and therapeutic qualities. Parameters that have been used in this research are macroscopic test, microscopic test, total ash content test, acid insoluble ash content test, water soluble simplicia content test, ethanol soluble simplicia content test, shrinkage drying test, and Phytochemistry screening qualitatively. From the results, turmeric simplicia has met the requirements, while turmeric extract has  not eligible in requirements, because its acid insoluble ash content are not eligible. This expected because of the impurities which contamine the extract are silica and sand.  Silica can cuts the mucosa of the throat when used it orally. Turmeric extract in this research does not eligible and cannot be used for the next step.
Molecular Docking Terpinen-4-ol pada Protein IKK sebagai Antiinflamasi pada Aterosklerosis secara In Silico
Authors: Dewi Putu Pradnya Pramita
Published: September 2019

ABSTRACT

 

Atherosclerosis is a chronic inflammatory disease that begins with endothelial dysfunction, it caused fat accumulation and plaque growth in the inner arteries walls. Endothelial dysfunction will activate the Nuclear Factor Kappa B (NF-kB) pathway involving IKK proteins. Terpinen4-ol is constituent found in the bangle (Zingiber cassumunar) rhizome. The purpose of this study were to determine the affinity and mechanisms of terpinen-4-ol against IKK protein as anti-inflammatory in atherosclerosis performed using molecular docking method. The docking result are assessed from the binding energy and hydrogen bonds formed between terpinen-4-ol and protein. The result showed that terpinen-4-ol has activity in inhibiting the inflammatory process because it is able to disturb IKK protein with bond energy values -4.89 kcal/mol. The molecular mechanism in inhibiting the activity of IKK protein through the formation of hydrogen bonds in these proteins. These result show that terpinen-4-ol has the potential to inhibiting inflammatory process and it caused the formation of atherosclerotic plaque can be obstructed.

 

Keywords: Atherosclerosis, Terpinen-4-ol, Molecular Docking, In Silico
Pengaruh Persepsi Kegunaan, Kemudahan Penggunaan dan Norma Subyektif pada Minat Berperilaku Penggunaan E-Billing
Authors: Ratnadi Ni Made Dwi , Widanaputra Anak Agung Gde Putu
Published: September 2019

This study aims to examine the behavior of individual taxpayers that use e-billing. The study was conducted at the Primary Tax Office in the Province of Bali. Data was collected using surveys. The sample was selected using convenience non-probability sampling technique. The number of respondents analyzed was 120 people. A variance based structural equation modeling approach with the calculation process supported by the partial least square was used in data analysis. The results show that perceived usefulness has a positive effect on attitude toward using e-billing, ease of use has a positive effect on attitude toward e-billing, ease of use has a positive effect on the perceived usefulness. The attitude and subjective norms positively influence the interest of individual taxpayers in using the e-billing system in paying taxes.

Keyword: E-billing, perceived ease of used, usefulness, attitude
Pengaruh Karakteristik Perusahaan Pada Pengungkapan Tanggung Jawab Sosial Perusahaan
Authors: Suprasto Herkulanus Bambang , Haryanti Angelia Putri Surya
Published: September 2019

Tujuan penelitian ini untuk memberi bukti empiris pengaruh karakteristik perusahaan yang meliputi umur perusahaan, ukuran perusahaan, profitabilitas, dan ukuran dewan komisaris pada corporate social responsibility disclosure. Penelitian ini dilakukan pada perusahaan yang terdaftar di Bursa Efek Indonesia dengan periode pengamatan selama 3 tahun yaitu dari tahun 2015-2017. Sampel penelitian ini berjumlah 52 perusahaan dengan jumlah pengamatan sebanyak 110. Metode penentuan sampel menggunakan teknik purposive sampling. Hasil penelitian ini menunjukkan bahwa umur perusahaan dan ukuran perusahaan berpengaruh positif pada corporate social responsibility disclosure, sedangkan profitabilitas dan ukuran dewan komisaris tidak dapat dibuktikann berpengaruh pada corporate social responsibility disclosure.

Kata Kunci : corporate social responsibility disclosure, umur perusahaan, ukuran perusahaan, profitabilitas, ukuran dewan komisaris.
Peran Akuntan terhadap Implementasi Sustainable Development Goals: Perspektif Akademisi
Authors: Firmansyah Irman
Published: September 2019

Penelitian ini bertujuan untuk memberikan gambaran secara umum mengenai peran akuntan terhadap implementasi sustainable development goals. Metode penelitian menggunakan metode analytic network process. Hasil penelitian menunjukkan bahwa peran akuntan dalam implementasi Sustainable Development Goals yang terbagi ke dalam tiga aspek, yaitu peran organisasi profesi akuntansi yaitu harus memberikan masukan kepada pemerintah tentang SDGs. Sedangkan peran kedua yaitu akuntan profesional adalah bahwa seorang akuntan harus memberikan pesan-pesan unsur SDGs dalam memberikan rekomendasi atas laporan keuangan. Adapun peran ketiga yaitu akuntan pendidik adalah akuntan pendidik harus menyusun kurikulum Pendidikan yang menyesuaikan dengan tujuan SDGs.
Authors: Bhawana Kadek Weda Ari , Faiqoh Elok , Putra Dirgayusa I Gusti Ngurah
Published: September 2019

Lamun merupakan penyerap karbon terbesar kedua setelah terumbu karang di laut, dan sebagai penangkap sedimen yang menuju ke laut jadi lamun dapat dijadikan sebagai penyeimbang segala ekosistem di laut. Ekosistem padang lamun, berasosiasi dengan berbagai jenis biota laut yang bernilai penting yang mempunyai tingkat keragaman yang sangat tinggi. Lamun dapat mengalami kerusakan dipengaruhi oleh kondisi lingkungan dan aktivitas manusia seperti adanya proyek reklamasi di pulau serangan menyebabkan hilangnya habitat padang lamun. Hilangnya habitat lamun dapat menyebabkan biota-biota di sekitarnya juga ikut hilang khususnya biota biota yang menggunakan lamun sebagai makanan utamanya, seperti dugong dan penyu. Penelitian ini bertujuan untuk tingkat kelangsungan hidup lamun jika di transplantasi di wilayah perairan Serangan Utara dan untuk mengetahui laju pertumbuhan dari Rhizoma lamun jenis Thallasia hemprichii, Cymodocea rotundata, Halodule ununervis, dan Halophila ovalis yang ditransplantasi  di wilayah perairan Serangan Utara. Penelitian ini dilakukan pada bulan pebruari – april 2018. Lokasi penelitian terdiri dari  2 stasiun dengan stasiun 1 pada kawasan padat aktivitas manusia dan stasiun 2 tanpa aktivitas manusia. Transplantasi lamun dilakukan dengan menggunakan frame yang berbahan besi dengan ukuran 1x1 meter. Hasil penelitian menunjukan bahwa pada stasiun 1 tingkat kelangsungan hidup lamun lebih rendah dari stasiun 2, hal itu disebabkan karena aktivitas manusia yang padat pada stasiun 1.  Begitu juga laju pertumbuhan di stasiun 1 lebih rendah dari stasiun 2. Hal ini juga dapat dikarenakan dari kualitas air yang lebih rendah pada stasiun 1.
Authors: Prabaswari Dewa Ayu Mira , Nurweda Putra I Dewa Nyoman , Karim Widiastuti
Published: September 2019

ABSTRACT

 

DEWA AYU MIRA PRABASWARI. 1414511013. Identification and Abundance of Bacteria Enterococcus spp. on Mucus Coral in Pemuteran Waters, Bali (Supervisor: I Dewa Nyoman Nurweda Putra dan Widiastuti).

 

Indonesia's geographical location in the area of the world's coral triangle causes the high number of hard coral species. Coral reefs have various functions as habitats of various marine biota such as spawning and natural protection from abrasion hazard. Domestic pollution has a relatively large contribution to coral reef damage. Human activities and river flows carry particulates from land in the form of sediments or organic materials that enter into the sea so that it can lead to the occurrence of pollution of domestic waste. Bacteria Enterococcus spp. is a bacteria found in domestic waste that is used as an indicator of domestic waste pollution. The method of sampling of coral mucus is done by purposive sampling method, where the determination is based on the existence of coral reefs and different coastal conditions. Sampling of coral mucus at each station is by randomly selecting 3 genus of corals in each of 3 replicates of belt 20 x 2 m. Coral mucus samples of 10 ml will be inoculated on Slanetz and Bartley selective media. The presence of Enterococcus spp. which grows on the media is indicated by a colony that grows red. Bacterial identification was analyzed using descriptive analysis, whereas bacterial abundance was analyzed by One Way Anova to determine the difference of bacterial abundance in each station. The result showed that Enterococcus spp. were identified in the dominant coral colonies in Pemuteran waters which sampling stations characterized by the growth of red bacterial colonies on selective media and there was no difference in the abundance of Enterococcus spp. bacteria between different coral genus in each sampling station showing domestic contamination spread evenly on all coral species.
PEMETAAN LAHAN POTENSIAL BUDIDAYA LAUT IKAN KERAPU BEBEK Cromileptes Altivelis DI DESA PEMUTERAN, KECAMATAN GEROKGAK, KABUPATEN BULELENG, BALI
Authors: Pratama Hendra Yoga , Nurweda Putra I Dewa Nyoman , Ria Puspitha Ni Luh Putu
Published: September 2019

The potential of aquaculture in Indonesia is very large, especially fish and mollusks. Around 1.052.720 ha total potential sea area for fish cultivation such as snapper, beronang, and grouper. One potential that needs to be developed in the field of fisheries is duck grouper (Cromileptes altivelis). One area in Indonesia especially in Bali, which conducting marine aquaculture using floating net cage system is Pemuteran Village, Gerokgak District, Buleleng Regency, Bali. This study aimed to determine the right information and improve the potential of the tap nets for the activity of duck grouper at Pemuteran Village level can be done with floating net cage system. In this study three stages were carried out, namely interpolation, reclassification, and overlay. Based on the result of overlay of all spatial information, a potential map for the activity of duck grouper cultivation with KJA system is divided into 2 conformity classes, namely: S1 for the appropriate category (very suitable),  S2 (quite appropriate category ) and T (for not suitable category). Based on the map in figure (3), it shows that suitable results for agriculture in Pemuteran village indicate that proper resources for aquaculture are in the right system KJA is Very suitable (S1) of 1,67 km2,  quite appropriate (S2) of 6,25 km2 and not suitable (T) of 1,31 km2.
Competition Law and Policy Harmonisation: Its Relation to Fair Competition Realisation in ASEAN Single Aviation Market
Authors: Surya Putra A. A. B. N. A.
Published: September 2019

A well-functioning ASEAN Single Aviation Market Requires a level-playing field and fair competition. ASEAN does not have a multilateral agreement on competition related issues but opts to harmonise its Member States’ domestic legislation. This article asks whether this approach is appropriate to realise fair competition in ASEAN Single Aviation Market. It finds that mere harmonisation of laws and policies is insufficient without being complemented by effective implementation and enforcement. While regional enforcement is the ideal way of preventing and opposing unfair competition, this article also proposes the adoption of the concept of international comity as an achievable alternative to currently unequal ASEAN competition laws or the absence thereof.
Indigenous Whaling Tradition in Faroe Islands under International Law
Authors: Setyonugroho Olivia Martha , Wisanjaya I Gede Pasek Eka , Yasa Made Maharta
Published: September 2019

The issue of whaling has been extensively debated in various international occasions since it causes a declines in many of the world’s whale population. Presently, Faroe Islands is one of the few regions in Denmark that still adamantly practiced whaling for traditional purposes, even though Denmark itself has prohibit it. This writing aims to analyze the whaling tradition in Faroe Islands from the International Law perspective. Further, to examine whether Denmark has an international obligation to end whaling activities in Faroe Islands. The method that is used in this writing is the normative legal research. The result of this analysis shows that the tradition in Faroe Islands is consistent with International Law, thus Denmark has no international obligation to end the tradition.
Has Financial Policy Intervention Benefited Local Society Affected by Natural Disaster?: Questioning the Utilitarian Approach
Authors: Putra Perbawa Ketut Sukawati Lanang
Published: September 2019

Mount Agung eruptions have an impact on economic losses, especially the banking sector in Bali. Entrepreneurs and bank debtors, especially in Karangasem Regency and its surroundings, ask for relief from the implementation of the provisions of their credit agreements in terms of time, interest and also obligations performance.  It is a legal research that focuses on analyzing the utilitarian approach used by the Indonesian Financial Services Authority (Otoritas Jasa Keuangan/OJK) in the form of Banking-relaxation policy in supporting the local society who affected by natural disaster. It has been concluded that local society who affected by the eruption of Mount Agung in Karangasem Regency Bali may use ‘force majeure’ to suspend their obligation performance in any economic matters, including loan banking. In addressing this issue, OJK plays a role by issuing financial policy for the 3 years period that is expected to give a margin of appreciation for local society to re-arrange their economic situation after the disaster. Such policy, seems has not properly been implemented by all banks in related area. Therefore, a utilitarian approach that inspired the OJK financial relaxation policy should be improved by taking into consideration the concerns on cultural-economic issues, the real declining and uncertain situation of the local economy, and the fragile tourism industry in Karangasem regency.
O estágio na formação de professores: um relato de experiência e sua contribuição para o aprimoramento da prática docente
Authors: Giuliani Caroline dos Santos , Medeiros Angélica Pott de , Dillenburg Andreia Inês
Published: September 2019

Devido às dificuldades encontradas ao exercer a profissão docente, universidades de diversos países vêm discutindo sobre os cursos de formação de professores/pedagógica. Assim, este trabalho objetivou relatar as experiências vividas, desafios e dificuldades encontradas durante um estágio curricular e analisar a influência do curso de formação de professores para o desenvolvimento da prática docente. As práticas foram propostas no curso de formação pedagógica e desenvolvidas em cursos de nível técnico da Universidade Federal de Santa Maria. Verificou-se que os cursos de formação pedagógica são importantes ferramentas, assim como uma oportunidade de desenvolvimento aos bacharéis e tecnólogos, enquanto futuros professores, de desenvolver as habilidades necessárias para a prática docente.
Concepções e relações estabelecidas entre planejamento e avaliação: o papel do coordenador pedagógico
Authors: Gallon Mônica da Silva , Madruga Zulma Elizabete de Freitas , Silva Carla Melo , Rocha Filho João Bernardes
Published: September 2019

O artigo apresenta uma análise das concepções e relações que professores integrantes de uma escola localizada na região metropolitana de Porto Alegre, RS, mantêm sobre planejamento e avaliação. As ideias desses docentes são investigadas a partir do foco no papel do coordenador pedagógico e de como este influencia o espaço escolar. O estudo foi de caráter qualitativo e, para o tratamento dos dados, empregou-se a Análise Textual Discursiva. Como resultado, observou-se convergências quanto à forma de perceber a avaliação, não como produto final, mas como modo de redirecionar as práticas e repensar a atuação docente.
Expansion in the absence of crossbite – rationale and protocol
Authors: Krishnaswamy N. R.
Published: September 2019

Transverse maxillomandibular discrepancies are a major component of several malocclusions. Clinically, posterior crossbite is a common and valid indicator of maxillary transverse problems and orthopedic and orthodontic forces are routinely used to correct maxillary transverse deficiency. However, crossbite and transverse discrepancies are not a homologous group but must be viewed as a continuum with varying degree of abnormality. The etiology, diagnostic protocol, rationale, and procedures employed for correcting maxillary transverse discrepancy in the absence of crossbite are discussed in the article.