bluuebunny/crossref_metadata_2025 huggingface dataset:
Factores epidemiológicos, sociales y ecológicos del dengue en Ecuador [Epidemiological, social and ecological factors of dengue in Ecuador]
Authors: Alvarado-Velez Ashley Katheryn , Ibarra-Guevara Joel Zahaid , Mosquera-Freire Edison German , Valverde-González Carlos Alberto
Published: February 2025

Objetivo: analizar los factores epidemiológicos, sociales y ecológicos del dengue en Ecuador. Método: Revisión sistemática en 15 articulos científicos. Resultados y Conclusión: El dengue en Ecuador representa un desafío significativo para la salud pública, determinado por la interacción de factores epidemiológicos, sociales y ecológicos. La circulación simultánea de múltiples serotipos del virus, las condiciones climáticas favorables para la proliferación del vector Aedes aegypti y las inequidades sociales, como la pobreza y el acceso limitado a servicios básicos, son determinantes clave en su persistencia y expansión.
Comparison of the effects of different aerobics training modes on sports injury risk of college students
Authors: Tian Rong , Feng Xin
Published: February 2025

Aerobic exercise is recognized for its multiple health advantages, which include increased cardiovascular endurance, metabolic efficiency, and mental well-being. Aerobic exercise is important for college students because it promotes general physical health and stress management during a pivotal period in their lives. The objective of this research is to analyze and compare the impact of different types of aerobics training on sports injury risk among college students. A total of 235 college students participated in this analysis; they were randomized and separated into four distinct groups: three experimental groups (EG), such as traditional aerobics training, high-intensity interval (HII) aerobics training, and dance-based aerobics training, and a control group (CG) received no aerobics training. The research consumed 8 weeks, with each group completing their allocated training mode two times per week. Self-reports, physical examinations (muscle tiredness, joint strain), and fitness tests were utilized to evaluate the risk of injuries. The data was analyzed using statistical methods and SPPS software. The findings suggest that high-intensity interval aerobics significantly increased fitness; they also increased the risk of injury, especially to the lower limbs. While traditional aerobics training showed modest improvements and a decreased injury rate, dance-based aerobics offered balanced fitness and injury prevention advantages, as well as increased joint mobility and flexibility. The CG demonstrated no significant changes in injury rates or fitness improvements. This analysis emphasizes how crucial it is to customize aerobics programs to each participant’s level of fitness reduce the risk of injury and maximize health benefits.
Exploration of structural mechanics and biomimetic design in sculpture art creation
Authors: Guo Jing , Zu Jinxiu
Published: February 2025

With the development of economy, the public’s demand for cultural life is increasing. Sculpture brings a dynamic experience to the urban landscape, enabling people to actively participate and integrate into the landscape space, thus adding to the urban cultural construction and enhancing the variability and depth of space. Based on the principle of bionic design, this paper compares the degree of similarity of the original organisms, and divides the morphology bionic into figurative bionic, abstract bionic, and metaphorical bionic. Combined with the structural stress characteristics, the spatial finite element model is established, and according to D’Alembert’s principle, the vibration equilibrium equation is associated, and the vibration mode superposition method power analysis method is applied to analyze the modal state of a sculpture. The results show that: The horizontal direction of the vibration mode coefficient has reached more than 0.9, the period and frequency of the sixth and seventh order vibration modes are the same, both are 0.3948 s and 2.5699 Hz. Calculating the ultimate bearing capacity of the structure under all the conditions, the maximum stress ratio of the strength of each member of the sculpture is 0.96987, which indicates that the strength of all the structural members meets the requirements of the design of the sculpture. The overall stability of the sculpture is analyzed, when the order is 5, the buckling factor under three kinds of loading conditions are 208.5974, 114.1648, 124.9748, which indicates that the sculpture structure designed according to bionics has good overall stability.
The impact of enterprise digital transformation on employee health management: A study of physiological responses from biomechanics perspective
Authors: Wang Xinyan , Zhang Aiyanwen , Ma Xiaohan , He Senbo , Kong Weibo , Hu Haipeng , Han Xuetao
Published: February 2025

This paper discusses the impact of enterprise digital transformation on employee health management from the perspective of biomechanics, especially the change law of employee physiological response and the underlying mechanism under the new work mode and technology application. By introducing a theoretical framework of biomechanics, this study evaluates the specific impact of changes such as office automation, remote work and the use of smart devices on the physical load of employees, and uses computer modeling technology to predict the potential health risks under different working conditions. In this study, a hybrid model combining Probabilistic neural Network (PNN) and Gated Recurrent Unit (GRU) was used to deal with complex time-series data analysis tasks to improve the prediction accuracy of employee health status. Experimental results show that the proposed PNN-GRU model performs well in the task of health state recognition, especially in fatigue and pain detection, with the accuracy of 94.7% and 97.1% respectively, which is significantly better than other algorithms.
Interactive motion graphics development: User experience design themed on the 24 solar terms integrating biological rhythms
Authors: Xia Yueman
Published: February 2025

This study aims to explore the development of interactive motion graphics themed around the “24 solar terms” from a biomechanical perspective, integrating user experience design with biorhythm concepts. Biorhythms refer to the biomechanical changes in humans, animals, and plants in response to different solar terms. The 24 solar terms, a significant part of traditional Chinese culture, not only reflect the ecological behaviors of animals and the biomechanical adaptations of plants to environmental changes but are also closely linked to the biomechanical variations in human physiological states. By incorporating biomechanical principles and bionic technology into motion graphic design, the study seeks to create interactive experiences that are more aligned with biological adaptability, catering to users’ physiological needs and cultural identity. The study begins by analyzing the cultural significance of the 24 solar terms and their impact on human life, revealing their critical connection to the biomechanics of human physiological states, such as dietary habits, sleep patterns, and emotional conditions. Based on these findings, a novel motion graphic design method is proposed, leveraging deep learning techniques grounded in bionic principles (e.g., the VGG-19 model) to monitor and analyze users’ biorhythms in real-time. This enables dynamic adjustments to graphic content and interaction modes, enhancing user immersion and engagement. Furthermore, the study explores how information modeling and reverse engineering techniques can digitize traditional cultural elements and biomechanical characteristics associated with different solar terms, creating interactive graphics that combine cultural depth with biological adaptability. This design not only improves user experience but also provides new perspectives and methods for the preservation of cultural heritage. The effectiveness of the proposed method is validated through analysis in terms of user satisfaction, interactivity, and information transmission efficiency.
Structural Investigation and Photocatalytic Application of Sol-Gel Auto-Combustion Derived ZnAl2O4 Spinel for the Degradation of Organic Dye
Authors: Muhammad Javed  , Naeem Akbar
Published: February 2025

Herein, we have synthesized ZnAl2O4 aluminate by the sol-gel auto-combustion method and sintered at 900 °C. Rietveld refinement analysis of XRD data confirmed the formation of the normal spinel structure with the Fd3m space group. The crystallite size was calculated by using the Debye-Sherrer and W-H plots and was found to be 78 and 91 nm, respectively. Field emission scanning electron microscopy (FESEM) investigation revealed the polyhedral texture of synthesized aluminates with considerable porosity. The optical properties were investigated by using a UV-Vis spectrometer and the band gap was approximated to be 3.4 eV. The synthesized aluminate was also employed for the degradation of Crystal violet (CV) organic dye pollutant under solar light irradiation. It has been observed that the percentage degradation of dye was increased with contact time and significant removal of 80 % was achieved after 120 minutes. The degradation process followed the pseudo-first-order kinetic model. These insights might be significantly advantageous for environmental applications, including dye removal from aqueous solutions for wastewater remediation.
Determinants of Rotavirus among diarrheal children (0-5yrs) attending some health facilities in Sokoto Town, Nigeria
Authors: Salisu Garba  , Malami Dikko  , Barga Isiyaka Bala  , Zayyanu Malami  , Yusuf Sarkingobir
Published: February 2025

This study was carried out to molecularly detect and characterize Rotaviruses from children attending selected hospitals in Sokoto State. A total of 350 stools were collected from diarrheic children under five years of age.  Samples were analyzed for the presence of Group A rotavirus antigens using CUSABIO Human Rotavirus (RV Ag) ELISA kit. Result reveals that, children that were fed with breast milk and solid foods had the highest prevalence (39.6%) while children that were fed with solid food recorded only 15.1% prevalence. Chi-square analysis indicated statistical significant relationship between Rotavirus diarrhea and type of food fed, P<0.05 (0.0204). Major sources of water of the family of infected children is Tap water (54.75%) and well water (39.6%) respectively, while River and Pond water was 3.8% and 1.9%. respectively and there is statistical association between rotavirus diarrhea and source of water (p<0.05). Children that often had contact with animals have high prevalence (69.8%) than their counterparts (5.7%). Chi-square analysis indicated significant association of Rotavirus diarrhea and child’s contact with animals (P<0.05). The percentage positive was higher in children whose parents are civil servants (47.2%) and is lower in children of un employed parents (28.3%). Children whose parents had primary level of educations had the highest number of rotavirus disease. There is significant association between Rotavirus disease and type of food, source of water, contact with animals and level of education of the parents. Interventions including should be provided to safeguard public health against the Rotavirus.
ATUALIZAÇÕES NO TRATAMENTO DA INSUFICIÊNCIA CARDÍACA: TERAPIAS EMERGENTES E PROTOCOLOS CLÍNICOS
Authors: Brugnera Carla Guerra , Abreu Marciely Maria de Lima , Cisne Ana Gabriela Vasconcelos , Freitas Neto Maurício Medeiros de , Pereira Yasmim Figueiredo , Battisti Gabriel Augusto Mattei , Damasceno Bárbara de Pinho Prisco , Murad Gabriel Fernandes , Santana Catiane Ferreira , Melo Carlos Daniel Spindola , Santos Filho Marcos Gonçalves Amorim Dos , Baratta Lys Ponte Moreira , Batista Guilherme Sousa , Sena Antonio Victor Azevedo , Silva Ana Paula Rodrigues da Silva e
Published: February 2025

A insuficiência cardíaca (IC) é uma condição clínica complexa e progressiva que afeta milhões de pessoas em todo o mundo, com alta morbidade e mortalidade. Apesar dos avanços no entendimento da patofisiologia e no desenvolvimento de tratamentos ao longo das últimas décadas, a insuficiência cardíaca continua a representar um grande desafio médico e uma carga significativa para os sistemas de saúde. O presente artigo tem como objetivo geral revisar as atualizações mais recentes no tratamento da insuficiência cardíaca. A pesquisa é fundamentada em uma revisão abrangente da literatura existente, para a coleta dos dados, foi utilizada a base de dados PubMed e Scielo, a pesquisa foi conduzida com os termos “Insuficiência Cardíaca”, “Terapias Emergentes”, “Protocolos Clínicos “, aplicando o operador booleano “AND”. A revisão bibliográfica revelou que as atualizações no tratamento da insuficiência cardíaca têm proporcionado avanços significativos na melhora do prognóstico e na qualidade de vida dos pacientes. Terapias emergentes, como os inibidores de SGLT2, antagonistas de mineralocorticoides e medicamentos moduladores da resposta inflamatória, têm mostrado eficácia no controle dos sintomas e na redução da mortalidade, especialmente quando combinadas com dispositivos terapêuticos avançados, como marcapassos e sistemas de ressincronização cardíaca. Além disso, a personalização do tratamento, com base em biomarcadores e uma abordagem multidisciplinar, tem se mostrado crucial para otimizar o manejo da insuficiência cardíaca. Contudo, apesar dos avanços, ainda existem desafios a serem superados, como a acessibilidade a essas terapias inovadoras e a necessidade de estratégias de manejo das comorbidades associadas. A continuidade do desenvolvimento de tratamentos e a ampliação do acesso a terapias eficazes são essenciais para garantir que os benefícios dessas novas abordagens sejam disseminados de maneira equitativa, melhorando os resultados para todos os pacientes com insuficiência cardíaca. A implementação de políticas públicas e o investimento em educação e infraestrutura de saúde são fundamentais para maximizar o impacto positivo dessas inovações no tratamento da doença.
Impacto da catarata congênita no desenvolvimento visual infantil
Authors: D'Apolito Nicoly Layla Bonifácio , Borges Jhonatan Lucas Ferreira , Sales Hemily da Silva , Morera Chabely Sanchez , Brito Jussara da Silva , Mendonça Flávia Silva , Lins Letícia da Costa , Discacciati Renato , Surlo Heitor Filipe , Gurgel Felipe Moraes Cortez , Silva Ana Beatriz Monteiro Correa da Costa e , Ramos Clara Alvarenga Moreira Carvalho , Lima Rebeca Maria Amorim Alves de , Tavares Mayane Freire
Published: February 2025

O presente estudo revisou o impacto da catarata congênita no desenvolvimento visual infantil, utilizando uma abordagem de revisão integrativa. O objetivo foi   avaliar como a presença da catarata congênita afeta o desenvolvimento visual da criança e quais são os impactos no desenvolvimento neurovisual e funcional. A metodologia consistiu em uma revisão integrativa realizada nas bases de dados Scientific Electronic Library Online (SCIELO), Cochrane e Medline, utilizando descritores de ciências da saúde relacionados ao tema, como “Cataract”, “Child Development” e “Early Diagnosis”. Os resultados mostraram que a catarata congênita é uma causa significativa de deficiência visual infantil, frequentemente resultando em ambliopia. O diagnóstico e tratamento precoces são essenciais para prevenir danos permanentes à visão.
PERANCANGAN SISTEM INFORMASI POSYANDU BERBASIS WEB DESA SAMBIHARJO DENGAN METODE PENGEMBANGAN WATERFALL
Authors: Pamungkas Nanda Putra , Setiyawan Muhammad , Widiati Ina Sholihah
Published: February 2025

Perkembangan teknologi informasi yang pesat saat ini sangat dibutuhkan untuk membantu kinerja suatu organisasi. Salah satu organisasi yang membutuhkan sistem informasi adalah pos pelayanan terpadu (posyandu) merupakan layanan kesehatan untuk ibu dan anak. Kegiatan posyandu seperti mengukur berat badan dan tinggi anak, pemberian vitamin dan imunisasi, penyuluhan kesehatan, serta pemberian makanan tambahan balita. Permasalahan yang terjadi pada posyandu di desa Sambiharjo, kecamatan Paranggupito, kabupaten Wonogiri adalah pencatatan data balita masih manual atau tulis tangan sehingga proses input dan pencarian data balita memerlukan waktu yang lebih lama. Tujuan penelitian adalah membuat sistem informasi posyandu untuk memudahkan kader posyandu. Metode pengembangan sistem yang digunakan adalah metode waterfall. Hasil penelitian ini adalah sistem informasi posyandu desa Sambiharjo yang digunakan oleh kader posyandu dalam melakukan pencatatan kegiatan, monitoring balita, dan pelaporan kegiatan posyandu.
Implementasi Sistem Absensi Berbasis Pengenalan Wajah Menggunakan Metode CNN dan Model FaceNet
Authors: Meldyantono Anggara Putra , Poetro Bagus Satrio Waluyo
Published: February 2025

Penelitian ini mengimplementasikan sistem absensi berbasis pengenalan wajah menggunakan metode Convolutional Neural Networks dan model FaceNet. Topik ini dipilih karena pengenalan wajah merupakan metode identifikasi yang efektif untuk aplikasi absensi, tetapi seringkali menghadapi tantangan pencahayaan rendah dan jarak objek yang bervariasi, terutama pada perangkat dengan spesifikasi menengah ke bawah. Sistem ini menggunakan Convolutional Neural Networks untuk ekstraksi fitur wajah, FaceNet untuk meningkatkan akurasi representasi wajah, dan Local Binary Patterns Histogram untuk menganalisis tekstur wajah guna meningkatkan performa pengenalan. Langkah-langkah yang dilakukan meliputi pengumpulan dataset wajah, penerapan model Convolutional Neural Networks dan FaceNet, serta evaluasi sistem dalam kondisi pencahayaan rendah dan berbagai jarak objek. Hasil pengujian menunjukkan akurasi 100% dengan tiga citra wajah meskipun dalam kondisi pencahayaan rendah. Sistem ini tetap menunjukkan performa yang baik meskipun ada variasi intensitas cahaya dan jarak objek. Kontribusi utama dari penelitian ini adalah pengembangan sistem pengenalan wajah berbasis Convolutional Neural Networks dan FaceNet yang efisien dan dapat diterapkan pada perangkat dengan spesifikasi terbatas untuk aplikasi absensi, dengan fokus pengembangan pada kestabilan di pencahayaan buruk dan uji coba di lingkungan nyata.
PERANCANGAN UI/UX TOKO BAJU MANUVESHKO BERBASIS MOBILE MENGGUNAKAN METODE USER CENTERED DESIGN
Authors: Ahmadi Rohani Nur , Saputro Indrawan Ady
Published: February 2025

Penelitian ini bertujuan untuk merancang dan mengembangkan antarmuka pengguna (UI) dan pengalaman pengguna (UX) aplikasi toko baju Manuveshko agar lebih optimal sesuai dengan kebutuhan pengguna. Metode yang digunakan dalam penelitian ini adalah User Centered Design (UCD), yang terdiri dari lima tahapan utama: Research, Concept, Design, Develop, dan Test. Pada tahap Research, dilakukan observasi dan wawancara terhadap pemilik toko serta pelanggan untuk mengidentifikasi kebutuhan utama dalam aplikasi. Tahap Concept berfokus pada penyusunan persona pengguna, alur pengalaman pengguna, serta fitur utama yang akan diintegrasikan. Selanjutnya, tahap Design mencakup pembuatan wireframe, flowchart, dan prototipe UI menggunakan Figma. Setelah itu, pada tahap Develop, rancangan UI/UX diimplementasikan ke dalam aplikasi. Terakhir, tahap Test dilakukan menggunakan metode Usability Testing dengan alat bantu Maze, yang melibatkan pemilik toko dan beberapa pengguna untuk menguji efektivitas navigasi dan kemudahan penggunaan aplikasi. Hasil pengujian menunjukkan bahwa 88% penguji dapat menyelesaikan tugas yang diberikan dalam waktu yang sesuai dengan standar keberhasilan, yang mengindikasikan bahwa rancangan UI/UX yang dibuat bersifat intuitif dan mudah digunakan. Simpulan, bahwa penerapan metode UCD dalam pengembangan UI/UX aplikasi Manuveshko berhasil meningkatkan pengalaman pengguna. Ke depan, penyempurnaan UI/UX, pengembangan fitur baru, serta evaluasi berkala direkomendasikan untuk menjaga kualitas dan relevansi aplikasi dengan kebutuhan pasar.
Kata Kunci: User Centered Design, UI/UX, Usability Testing, Aplikasi Manuveshko
PEMBUATAN LANSKAP FANTASI BERBASIS DIFFUSION MODELS DENGAN FINE-TUNING LOW-RANK ADAPTATION (LoRA)
Authors: Gholib Tsabit , Mulyono Sri
Published: February 2025

Adanya peningkatan jumlah pemain video game membuat industri game bersaing untuk menciptakan video game yang menarik, salah satunya dengan cara set-up lanskap secara imersif. Penelitian ini bertujuan untuk mengembangkan sistem yang mampu menciptakan lanskap fantasi dari deskripsi teks menggunakan Diffusion models dan Low Rank Adaptation sebagai metode fine-tuning. Stable Diffusion adalah jenis generative models yang dapat menghasilkan gambar dari teks. Low Rank Adaptation merupakan salah satu teknik fine-tuning yang hanya mengambil beberapa layer untuk dilatih. Dengan kolaborasi antara Stable Diffusion 2.1 dan fine-tuning Low Rank Adaptation (LoRA) mampu menghasilkan gambar lanskap fantasi yang dapat digunakan untuk menjadi landasan dalam pembuatan konsep art pada sebuah video game. Hasil pengujian menggunakan CLIP-based Maximum Mean Discrepancy (CMMD) adalah 0.726 yang menunjukkan bahwa skor model yang dihasilkan lebih rendah daripada model awal yang belum melalui proses fine-tuning yang memiliki skor 0.867. Serta nilai skor Fréchet Inception Distance (FID) yaitu 32.35 yang menandakan model cukup belajar dan mirip dengan konteks dataset asli.
IMPLEMENTASI STABLE DIFFUSION DAN FINE-TUNING LOW RANK ADAPTATION UNTUK PEMBUATAN LOGO
Authors: Mukaromah Naela , Mulyono Sri
Published: February 2025

Penelitian ini bertujuan untuk mengembangkan sistem yang mampu menghasilkan logo berdasarkan deskripsi teks menggunakan model Stable Diffusion versi 1.5 dan teknik Fine-Tuning Low Rank Adaptation (LoRA). Studi literatur dilakukan untuk memahami pendekatan terbaik dalam implementasi text-to-image, model stable diffusion, dan metode evaluasi gambar. Dataset yang digunakan terdiri dari 50 gambar logo yang dikumpulkan dari berbagai sumber dan dilengkapi dengan image captioning. Dataset ini kemudian diproses melalui tahap preprocessing yang mencakup resize, standarisasi format, cropping, serta rotation dan flipping untuk meningkatkan variasi data. Pengembangan model melibatkan pelatihan Stable Diffusion 1.5 dengan fine-tuning LoRA, yang memungkinkan model beradaptasi dengan tugas spesifik tanpa memerlukan sumber daya komputasi yang besar. Proses pelatihan dilakukan dengan 400 iterasi untuk menghindari overfitting pada dataset yang terbatas. Pengujian sistem dilakukan dengan menghasilkan gambar berdasarkan teks deskripsi yang sama dengan caption data uji, kemudian dievaluasi menggunakan metrik CLIP-MMD dan Frechet Inception Distance (FID). Hasil penelitian menunjukkan bahwa model yang telah dilatih dapat menghasilkan gambar logo yang sesuai dengan deskripsi teks, dengan nilai CLIP-MMD dan FID yang menunjukkan kesesuaian gambar dengan dataset uji. Penelitian ini berkontribusi dalam pengembangan teknologi AI generatif untuk kebutuhan desain logo bagi pelaku UMKM, sehingga memungkinkan pembuatan logo secara efisien tanpa memerlukan keahlian desain grafis. Dengan penerapan teknik LoRA, penelitian ini juga membuktikan efektivitas fine-tuning dalam meningkatkan performa model generatif dengan sumber daya yang lebih rendah.
Kata Kunci: Text-to-Image, Stable Diffusion, LoRA Fine-Tuning, AI Generatif, Evaluasi Gambar
APPLICATION OF LOGISTIC REGRESSION TO THE ASSESSMENT OF THE RELATIONSHIP BETWEEN TENANTS' SOCIO-ECONOMIC CHARACTERISTICS AND LEASE PERFORMANCE IN THE AKURE PRIVATE RENTED SECTOR
Authors: OLUWASOLA STEPHEN ADEBISI
Published: February 2025

Residential property investment has significantly contributed to the overall performance of the real estate sector in the economy. However, it has been bewildered by non-lease performance due to the high rate of rental default despite the adoption of tenant selection procedures. This study assessed the relationship between residential property tenants' socioeconomic characteristics and lease performance in the Akure private rented sector. The target populations for this study are registered Estate Surveying and Valuation firms in Akure and tenants in their management portfolio. The researcher gathered data with structured copies of questionnaires administered to twenty-five (25) registered Estate Surveying and Valuation firms, as this aided in gathering data on the socio-economic characteristics of five hundred and twenty-seven tenants in their management portfolio. The data gathered on each tenant was matched with his lease performance. The data gathered by the researcher were analyzed using both descriptive (frequency distribution analysis) and inferential statistics (logistic regression analysis). The logistic regression analysis revealed that socio-economic characteristics such as gender, marital status, and nature of employment are more likely to influence lease performance in the private rented sector. The study, therefore, recommends that investors, Estate Surveyors, and Valuers pay close attention to tenants’ socio-economic characteristics in tenant selection in order to enhance residential property lease performance in the private rented sector.
MATHEMATICAL ASSESSMENT ON THE IMPACT OF INSECTICIDE SPRAY ON THE DYNAMICS OF MALARIA TRANSMISSION USING NON LINEAR MATHEMATICAL MODEL
Authors: ALHASSAN CHARITY JUMAI  , KENNETH OJOTOGBA ACHEMA
Published: February 2025

Malaria is a life threatening illness that affect millions of people all over the world even though significant effort have been implemented with the treatment of insecticide treated net, the disease remains chronic. In this work, we   used nonlinear mathematical model to analyzed the transmission dynamics of malaria disease. An insecticide control strategy was incorporated, using system of ordinary differential equations and established that the model is locally asymptotically stable when the associated reproduction number is less than unity. Numerical simulation was carried out and pertinent findings were displayed graphically. It was found that insecticide spray has a significant impact on malaria transmission.
SERVIÇOS E BENEFÍCIOS ECOSSISTÊMICOS DA PESCA ARTESANAL MARINHA EM SÃO GONÇALO DO AMARANTE – CEARÁ
Authors: Casemiro Maria Bonfim , Vasconcelos Fábio Perdigão , Matos Fábio de Oliveira , Rocha Cristiano da Silva , Barra Otávio Augusto de Oliveira Lima
Published: February 2025

Os serviços e benefícios ecossistêmicos são bens tangíveis e intangíveis produzidos pelos ecossistemas na busca pelo bem-estar humano, e vem utilizados de maneira direta e/ou indireta pela sociedade ao longo do tempo. A análise deles vem sendo cada vez mais discutida no âmbito da ciência geográfica, em função da pressão populacional e da busca por desenvolvimento econômico que os ambientes costeiros vêm sofrendo nos últimos anos. O trabalho objetiva analisar a relação dos serviços e benefícios ecossistêmicos gerados pela pesca artesanal na área marinha de São Gonçalo do Amarante-Ce. Para tanto, a metodologia consistiu em um estudo qualitativo a partir da aplicação de questionários aos atores sociais da área de estudo. Os resultados revelaram que a pesca artesanal contribui como fonte alimentar e possui papel importante na economia local e na preservação cultural. No entanto, há desafios significativos a serem superados, como reconhecimento social da profissão e a busca por formas sustentáveis de gerar renda e preservar tradições em um ambiente em constante mudança.
SIV-specific neutralizing antibody induction following selection of a PI3K drive-attenuated nef variant
Authors: Yamamoto Hiroyuki , Matano Tetsuro
Published: February 2025

HIV and simian immunodeficiency virus (SIV) infections are known for impaired neutralizing antibody (NAb) responses. While sequential virus-host B cell interaction appears to be basally required for NAb induction, driver molecular signatures predisposing to NAb induction still remain largely unknown. Here we describe SIV-specific NAb induction following a virus-host interplay decreasing aberrant viral drive of phosphoinositide 3-kinase (PI3K). Screening of seventy difficult-to-neutralize SIV
mac239
-infected macaques found nine NAb-inducing animals, with seven selecting for a specific CD8
+
T-cell escape mutation in viral
nef
before NAb induction. This Nef-G63E mutation reduced excess Nef interaction-mediated drive of B-cell maturation-limiting PI3K/mammalian target of rapamycin complex 2 (mTORC2).
In vivo
imaging cytometry depicted preferential Nef perturbation of cognate Envelope-specific B cells, suggestive of polarized contact-dependent Nef transfer and corroborating cognate B-cell maturation post-mutant selection up to NAb induction. Results collectively exemplify a NAb induction pattern extrinsically reciprocal to human PI3K gain-of-function antibody-dysregulating disease, and indicate that harnessing the PI3K/mTORC2 axis may facilitate NAb induction against difficult-to-neutralize viruses including HIV/SIV.
Activation of autophagy is required for clearance of mitochondrial ROS in patients with asthenozoospermia
Authors: Wang Xiaona , Huang Shiyuan , Zhao Yu , Chen Hua , Yan Linzhi , Ge Hongshan , Wu Xinmei
Published: February 2025

Autophagy is regarded as an essential process for maintaining cell homeostasis. However, its role in the regulation of sperm motility is still less understood. In this study, we found that mitochondrial oxidative species (mROS) levels were elevated, but ATP levels and mitochondrial membrane potential (MMP) levels were reduced in human sperm with low motility (also called asthenozoospermia, AS) as compared to normal human sperm (normal sperm, NS). Immunocytochemistry staining showed that LC3 was mainly located in the neck of sperm. Western blot analysis showed that AS patients had elevated levels of the autophagy-related proteins LC3, Atg5, Atg7, and Beclin1. Flow cytometry showed that 3-MA treatment reduced sperm motility and MMP, but increased mROS. The results indicate that autophagy is essential for the clearance of mROS in sperm and the maintenance of mitochondrial function.
Corporate Social Responsibility, Good Corporate Governance and Financial Sustainability: A Financial Stability Role
Authors: Rahim Sabila Aulia , Aisyah Esy Nur
Published: February 2025

Corporate social responsibility and good corporate governance are elements in Sharia bank operations that balance social responsibility and business interests. Financial sustainability is also an important indicator in assessing the long-term performance of financial institutions, including Islamic banks. Meanwhile, financial stability plays a role in strengthening the relationship between CSR, GCG and financial sustainability This raaesearch aims to analyze the influence of CSR and GCG on financial sustainability with financial stability as intervening variable in Sharia Commercial Banks in Indonesia. The sampling technique used was purposive sampling, with a total sample of 9 Islamic commercial banks in Indonesia in 2019-2023, and panel data path analysis was used. The indicator of the CSR variable uses the Corporate Social Responsibility Disclosure Index ( ) according to GRI standards, GCG is measured using the GCG score indicator, financial sustainability uses the SFR (Sustainability Financial Ratio) and financial stability is measured using the z-Score. The research results show that CSR does not affect financial sustainability directly or through financial stability. GCG also does not affect financial sustainability directly or through financial stability. Financial stability itself does not affect financial sustainability. Besides, CSR does not affect financial stability, but GCG affects financial stability. From the results of this study, Islamic banking sector companies must strengthen the implementation of GCG in order to maintain long-term financial stability. In good GCG there is transparency, accountability, and good management in the company so that it can increase investor confidence and reduce financial risk.
Synthesis, Characterization and Biological Activity of New Pyrimidine Schiff Base and Its Cu(II), Ni(II) Complexes
Authors: Sakhare D.T.
Published: February 2025

The novel Schiff base ligand (E)-2-(((2-hydroxynaphthalen-1-yl)methylene)amino)-6-methylpyrimidin-4-ol has been attained through the condensation of 2-amino-4-hydroxy-6-methylpyrimidine and 2-hydroxy-1-naphthaldehyde. Metal complexes of the Schiff base were formed by the interaction of the Schiff base and metal nitrate in an ethanol solution. The complexes were isolated, cleaned, and dried. The Schiff base appears pale yellow, whereas the Cu(II) and Ni(II) complexes exhibit a light yellow color. The synthesized compounds have been characterized by FT-IR, 1H-NMR, and UV-Vis techniques for the ligands, while FT-IR, UV-Vis, along with all reactions monitored by TLC, molar conductivity, and magnetic susceptibility measurements were employed for the corresponding complexes. The complexes are paramagnetic. The results from the molar conductivity measurements indicated that all complexes are non-electrolytes in (DMSO). An octahedral geometry is anticipated for all the complexes. The ligands are bidentate (L) through phenolic (OH) and azomethine nitrogen. The ligand and its complexes were evaluated for their antifungal and antibacterial efficacy against Aspergillus niger, Penicillium chrysogenum, Fusarium moniliforme, Aspergillus flavus, Escherichia coli, Salmonella typhi, Staphylococcus aureus, and B. subtilis. The results demonstrated that the complexes exhibited significant antifungal and antibacterial activities.
Mortality in Patients Hospitalized for COVID-19 vs Influenza in Fall-Winter 2023-2024
Authors: Xie Yan , Choi Taeyoung , Al-Aly Ziyad
Published: May 2024

This cohort study evaluates the risk of death in patients hospitalized for COVID-19 or seasonal influenza following the emergence of the JN.1 variant in winter 2023.
Autofluorescence-Guided Total Thyroidectomy in Low-Volume, Nonparathyroid Institutions
Authors: Abood Ali , Rolighed Lars , Triponez Frédéric , Vestergaard Peter , Bach Jacob , Ovesen Therese
Published: May 2024

Importance

Hypoparathyroidism following thyroid surgery is a serious complication that occurs frequently when surgery is performed by low-volume thyroid surgeons without experience in parathyroid surgery.

Objective

To evaluate the occurrence of hypoparathyroidism following total thyroidectomy after the introduction of autofluorescence in low-volume, nonparathyroid institutions.

Design, Setting, and Participants

This prospective, multicenter cohort study, with a follow-up period of up to 1 year, was conducted in Denmark at 2 low-volume nonparathyroid institutions between January 2021 and November 2023. All adult patients referred for total thyroidectomy were assessed for eligibility (n = 90). Only patients with no history of thyroid surgery were considered (n = 89). Patients who only underwent lobectomy (n = 6) or declined to participate (n = 5) were excluded. All included patients completed follow-up. The prospective cohort was compared with a historical cohort of successive patients undergoing primary total thyroidectomy from 2016 to 2020 (before autofluorescence was available).

Intervention

Included patients underwent autofluorescence-guided total thyroidectomy.

Main outcomes and Measures

Rate of hypoparathyroidism. Immediate hypoparathyroidism was defined as the need for active vitamin D postoperatively, whereas permanent hypoparathyroidism was considered when there still was a need for active vitamin D 1 year after surgery.

Results

Seventy-eight patients underwent autofluorescence-guided surgery (mean [SD] age, 55.6 [13.1] years; 67 [86%] female) and were compared with 89 patients in the historical cohort (mean [SD] age, 49.7 [12.8] years; 78 [88%] female). The rate of immediate hypoparathyroidism decreased from 37% (95% CI, 27%-48%) to 19% (95% CI, 11%-30%) after the introduction of autofluorescence (P = .02). Permanent hypoparathyroidism rates decreased from 32% (95% CI, 22%-42%) to 6% (95% CI, 2%-14%) (P < .001), reaching 0% at the end of the study. More parathyroid glands were identified with autofluorescence (75% [95% CI, 70%-80%] vs 61% [95% CI, 56%-66%]) (P < .001) and less parathyroid glands were inadvertently excised (4% [95% CI, 1%-11%] vs 21% [95% CI, 13%-31%]) (P = .001).

Conclusions and Relevance

In this cohort study of autofluorescence-guided thyroid surgery in low-volume, nonparathyroid institutions, the use of autofluorescence was associated with a significant decrease in both immediate and permanent hypoparathyroidism. When autofluorescence was used, hypoparathyroidism rates were comparable with those of high-volume surgeons who also perform parathyroid surgery.
Opioid Coprescription Through Risk Mitigation Guidance and Opioid Agonist Treatment Receipt
Authors: Min Jeong Eun , Guerra-Alejos Brenda Carolina , Yan Ruyu , Palis Heather , Barker Brittany , Urbanoski Karen , Pauly Bernie , Slaunwhite Amanda , Bach Paxton , Ranger Corey , Heaslip Ashley , Nosyk Bohdan
Published: May 2024

Importance

At the onset of the COVID-19 pandemic, the government of British Columbia, Canada, released clinical guidance to support physicians and nurse practitioners in prescribing pharmaceutical alternatives to the toxic drug supply. These alternatives included opioids and other medications under the risk mitigation guidance (RMG), a limited form of prescribed safer supply, designed to reduce the risk of SARS-CoV-2 infection and harms associated with illicit drug use. Many clinicians chose to coprescribe opioid medications under RMG alongside opioid agonist treatment (OAT).

Objective

To examine whether prescription of hydromorphone tablets or sustained-release oral morphine (opioid RMG) and OAT coprescription compared with OAT alone is associated with subsequent OAT receipt.

Design, Setting, and Participants

This population-based, retrospective cohort study was conducted from March 27, 2020, to August 31, 2021, included individuals from 10 linked health administrative databases from British Columbia, Canada. Individuals who were receiving OAT at opioid RMG initiation and individuals who were receiving OAT and eligible but unexposed to opioid RMG were propensity score matched at opioid RMG initiation on sociodemographic and clinical variables. Data were analyzed between January 2023 and February 2024.

Exposure

Opioid RMG receipt (≥4 days, 1-3 days, or 0 days of opioid RMG dispensed) in a given week.

Main Outcome and Measures

The main outcome was OAT receipt, defined as at least 1 dispensed dose of OAT in the subsequent week. A marginal structural modeling approach was used to control for potential time-varying confounding.

Results

A total of 4636 individuals (2955 [64%] male; median age, 38 [31-47] years after matching) were receiving OAT at the time of first opioid RMG dispensation (2281 receiving ongoing OAT and 2352 initiating RMG and OAT concurrently). Opioid RMG receipt of 1 to 3 days in a given week increased the probability of OAT receipt by 27% in the subsequent week (adjusted risk ratio, 1.27; 95% CI, 1.25-1.30), whereas receipt of opioid RMG for 4 days or more resulted in a 46% increase in the probability of OAT receipt in the subsequent week (adjusted risk ratio, 1.46; 95% CI, 1.43-1.49) compared with those not receiving opioid RMG. The biological gradient was robust to different exposure classifications, and the association was stronger among those initiating opioid RMG and OAT concurrently.

Conclusions and Relevance

This cohort study, which acknowledged the intermittent use of both medications, demonstrated that individuals who were coprescribed opioid RMG had higher adjusted probability of continued OAT receipt or reengagement compared with those not receiving opioid RMG.
Drop‐on‐Demand Electrohydrodynamic Printing of Nematic Liquid Crystals
Authors: Kamal Waqas , Li Mengmeng , Sykes Thomas C. , Castrejón‐Pita Alfonso A. , Elston Steve J. , Morris Stephen M.
Published: May 2024

Electrohydrodynamic (EHD) printing of nematic liquid crystals (LCs) is demonstrated. Miniscule LC droplets, as small as 1 micron, are generated with the EHD printing system and deposited with high precision onto a glass substrate. Herein, we show how the voltage waveform and pulse frequency applied to the print nozzle influences the dynamics of the deposition process and the final landed footprint diameter of the printed spherical‐cap‐shaped LC droplets at the glass substrater. To complement results from high‐speed shadowgraphy imaging, simulations are employed to model the jetting process and the formation of the Taylor cone. Using EHD printing, results for two different printing modes, cone jetting and microdripping, are shown. The benefits and drawbacks of each mode are highlighted, and the paper is concluded with the demonstration of a printed alphanumeric pattern that showcases the capability of EHD printing to deposit very small volumes of nematic LC in order to form well‐defined spatial patterns.
Personalized Piezoresistive Anti‐Scar Orthosis with Precise Pressure Monitoring Function Based on Embedded 3D Printing
Authors: Wang Yilin , Zhou Xi , Zhong Jing , Zhan Jianan , Kong Yueying , Yin Junfeiyang , Gong Haihuan , Chen Qiwei , Li Shiyu , Zhao Hong , Wu Yaobin , Huang Wenhua
Published: May 2024

Hyperplastic scars, especially keloids, have posed a significant clinical challenge due to their high recurrence rate. Compression therapy, a cost‐effective treatment, has demonstrated efficacy in reducing scarring and preventing recurrence. However, the compression methods exhibit limitations in adapting to the complex contours and accurately adjusting the treatment pressure, resulting in unsatisfactory treatment effects. In this study, silicone is chosen as the substrate layer ink, while the conductive ink is developed by incorporating nano‐carbon black into the polymer composite. These are printed alternately within the supported gels to construct an integrated orthotic device with precise pressure control capabilities and complex structures. Results demonstrated the printed orthosis displayed excellent mechanical properties, durability and biocompatibility. It can successfully detect various stress changes with short response times. The utilization of finite element analysis aided in the design of personalized orthosis to achieve optimal pressure for scar treatment. Finally, orthosis‐mediated pressure treatment is performed on rat tail scar models. By monitoring resistance value, it can be inferred whether the treatment pressure applied by orthosis fell within an optimal range. Overall, personalized piezoresistive anti‐scar orthoses offer an accurate and effective treatment method for scar. This innovative approach presents a novel strategy in the realm of personalized scar management.
Amoeba‐Inspired Self‐Healing Electronic Slime for Adaptable, Durable Epidermal Wearable Electronics
Authors: Feng Yu , Wu Cong , Chen Meng , Sun Hui , Vellaisamy Arul Lenus Roy , Daoud Walid A. , Yu Xinge , Zhang Guanglie , Li Wen Jung
Published: May 2024

Epidermal electronics has garnered significant research attention due to its promising applications in wearable human‐machine interfaces and intelligent healthcare sensing. However, their widespread use faces challenges due to complex manufacturing processes, high material costs, inadaptability to different skin surfaces, and inadequate reusability. Herein, inspired by the biological reshapability and environmental adaptability of amoeba, an ultra‐deformable (≈2600% strain), bioadhesive (adhesive strength ≈3 kPa), strong self‐healing (fastest recovery time ≈1s, maximum wound distance ≈5 mm), and electromechanical‐durable wearable electronic slime (E‐slime) is proposed, which can instantaneously form on‐skin electronics in situ to detect body motion and physiological signals. E‐slime demonstrates desired sensing performance with high sensitivity (gauge factor 2.95), wide sensing range (up to 400% strain), and low detection limit (≈1% strain), which can seamlessly adhere to the skin and can be easily reused multiple times (≈100 cycles usage). E‐slime also enables on‐the‐fly deployment of motion monitoring tasks at various body locations, showcasing its versatility and reliability for body motion recognition and personal health monitoring. This study holds potential for next‐generation green electronics, motion sensing devices, and wearable human‐machine interfaces, ultimately helping to ensure healthy lives and promote well‐being.
Reversible Polarity Control in 2D MoTe2 Field‐Effect Transistors for Complementary Logic Gate Applications
Authors: Yu Byoung‐Soo , Kim Wonsik , Jang Jisu , Lee Je‐Jun , Hong Jung Pyo , Kwon Namhee , Kim Seunghwan , Ha Aelim , Kim Hong‐Kyu , Ahn Jae‐Pyoung , Jeong Kwangsik , Taniguchi Takashi , Watanabe Kenji , Wang Gunuk , Ahn Jongtae , Park Soohyung , Hwang Do Kyung
Published: May 2024

Precise control over polarity in field‐effect transistors (FETs) plays a pivotal role in the design and construction of complementary metal–oxide–semiconductor (CMOS) logic circuits. In particular, achieving such precise polarity control in 2D semiconductors is crucial for the further development of advanced electronic applications beyond unit devices. This paper presents a systematic investigation on the reversible transition of carrier types in a 2D MoTe2 semiconductor under different annealing atmospheres. Photoemission spectroscopy and density functional theory (DFT) calculations demonstrate that annealing processes in vacuum and in ambient air induce a modification in the density of states, resulting in alterations in p‐type or n‐type characteristics. These reversible changes are attributed to the physisorption and elimination of oxygen on the surface of MoTe2. Furthermore, it is found that the device geometry affects the polarity of the transistor. By strategically manipulating both the annealing conditions and the geometric configuration, the n‐ and p‐type unipolar characteristics of MoTe2 FETs are successfully modulated and ultimately demonstrating that the functionality of not only a complementary inverter with a high voltage gain of ≈20, but also more complex logic circuits of NAND and NOR gates.
Interlayer Interaction of Excitons and Magnons in Graphene/WS2/Néel‐Type Manganese Phosphorus Trichalcogenide Heterostructures
Authors: Zhao Shou‐Xin , Wang Jia‐Peng , Liu Yue , Han Hui , Li Hui , Zhang Jia , Zhen Liang , Li Yang , Xu Cheng‐Yan
Published: May 2024

2D materials, particularly 2D semiconductors, and layered antiferromagnetic (AFM) compounds, exhibit rich light‐matter coupling phenomena in low‐dimensional systems. In this work, the occurrence of interlayer exciton–magnon coupling (EMC) is observed in Néel‐type AFM of MnPX3 (X = S or Se) and monolayer (1L) WS2 heterostructures. The energy of neutral exciton in 1L WS2 can be tuned by the adjacent AFM order, resulting in an additional energy shift of 10–14 meV. Furthermore, by filtering the photoluminescence spectrum with graphene and conducting magnetic measurements, the correlation is elucidated between the interlayer EMC and AFM transition process. In MnPS3, this coupling behavior exhibits sensitivity to the changes of magnetic structures, manifesting with a correlated length ξ of 8.34 Å at temperatures higher than Néel temperature (TN). The decoupling process in WS2/MnPS3 heterostructure below 50 K is originated from a weak out‐of‐plane ferromagnetic order, confirming the presence of an XY‐type magnetic phase transition in MnPS3 at sub‐TN temperature. This study provides a fundamental understanding of EMC and its potential applications in the integration of optical and magnetic devices.