bluuebunny/crossref_metadata_2025 huggingface dataset:
Envirotyping within a multi-environment trial allowed identifying genetic determinants of winter oilseed rape yield stability
Authors: Corlouer Erwan , Sauvage Christopher , Leveugle Magalie , Nesi Nathalie , Laperche Anne
Published: June 2024

Key message

A comprehensive environmental characterization allowed identifying stable and interactive QTL for seed yield: QA09 and QC09a were detected across environments; whereas QA07a was specifically detected on the most stressed environments.

A main challenge for rapeseed consists in maintaining seed yield while adapting to climate changes and contributing to environmental-friendly cropping systems. Breeding for cultivar adaptation is one of the keys to meet this challenge. Therefore, we propose to identify the genetic determinant of seed yield stability for winter oilseed rape using GWAS coupled with a multi-environmental trial and to interpret them in the light of environmental characteristics. Due to a comprehensive characterization of a multi-environmental trial using 79 indicators, four contrasting envirotypes were defined and used to identify interactive and stable seed yield QTL. A total of four QTLs were detected, among which, QA09 and QC09a, were stable (detected at the multi-environmental trial scale or for different envirotypes and environments); and one, QA07a, was specifically detected into the most stressed envirotype. The analysis of the molecular diversity at QA07a showed a lack of genetic diversity within modern lines compared to older cultivars bred before the selection for low glucosinolate content. The results were discussed in comparison with other studies and methods as well as in the context of breeding programs.
Association between PD-1 single nucleotide gene variants and the risk of metastatic melanoma
Authors: Boutros Andrea , Carosio Roberta , Campanella Dalila , Banelli Barbara , Morabito Anna , Pistillo Maria Pia , Croce Elena , Queirolo Paola , Tanda Enrica Teresa , Raposio Edoardo , Fontana Vincenzo , Spagnolo Francesco
Published: June 2024

Previous studies showed an association between single nucleotide gene variants (SNVs) of PD-1 and cancer susceptibility. We analyzed PD1.5 C > T and PD1.7 T > C SNVs to investigate their association with the risk of developing metastatic melanoma (MM). Utilizing a cohort of 125 MM patients treated with anti-PD-1 agents and 84 healthy controls, we examined genotype/allele frequencies through a modified Poisson regression model, adjusted for age and sex. Our findings indicate that the PD1.5 T allele is associated with a reduced risk of MM, showing a significantly lower risk in both codominant (RR = 0.56, 95%CL: 0.37–0.87) and dominant (RR = 0.73 95%CL: 0.59–0.90) models. Conversely, the PD1.7 C allele is linked to an increased risk of MM, with the C/C genotype exhibiting a higher risk in the codominant (RR = 1.65, 95%CL: 1.32–2.05) and allelic (RR = 1.23, 95%CL: 1.06–1.43) models. These results are consistent with previous meta-analyses on other cancer types, mainly highlighting the PD1.5 SNV’s potential role in promoting anti-tumor immunity through increased PD1-positive circulating effector T cell activity.
The influence of epidural analgesic techniques on obstetrical outcomes
Authors: Wiesmann Christian , Horky Alex , Hentrich Anna , Bahlmann Franz , Louwen Frank , Al Naimi Ammar
Published: June 2024

Purpose

The aim of this study is to compare and evaluate the obstetrical differences between three techniques, including the programmed intermittent epidural bolus (PIEB), the patient-controlled epidural analgesia (PCEA), and the continuous epidural analgesia (CEA).

Methods

This is a retrospective cohort study that investigates the obstetrical outcomes of 2240 patients who received EA during labor in a tertiary maternal unit over the course of 9 years (2011–2018). The only inclusion criterion was the use of epidural analgesia during childbirth and the only exclusion criteria were multiplets’ gestation. Multivariate logistic regression, Kruskal–Wallis test, and the log-rank test were utilized to compare the differences between the three EA techniques in terms of cesarean section rate, the incidence of perineal tears, the use of Oxytocin, the duration of labor, and the incidence of paresthesia.

Results

Out of the 2240 included deliveries; 1084 utilized PIEB, 1086 PCEA, and 70 CEA techniques. The incidence of Cesarean section was the highest in the CEA group (45.7%) compared to PIEB (24.8%) and PCEA (24.4%) P < 0.001. A significantly shorter duration of labor (vaginal delivery) was observed in the PCEA group (n: 821, 336.7 min) compared to the PIEB group (n: 814, 368.8 min) P < 0.001. There were no statistically significant differences in the incidence of perineal tears, the need of uterotonics, and the incidence of paresthesia.

Conclusion

The results of this study indicate that the PIEB and PCEA techniques are superior to the CEA technique when it comes to analgesia during childbirth. In this study, the PCEA technique seems to be the best-suited technique for childbirth, since it had a significantly shorter duration of labor than the PIEB technique.
Interventional radiology for prevention and management of postpartum haemorrhage: a single centre retrospective cohort study
Authors: Storms Jazz , Van Calsteren Kristel , Lewi Liesbeth , Maleux Geert , van der Merwe Johannes
Published: June 2024

Purpose

Postpartum haemorrhage (PPH) remains a leading cause of maternal death despite current medical management. Surgical interventions are still needed for refractory bleeding. Interventional radiology (IR) can be a successful intermediary that avoids the need for hysterectomy. Nevertheless, IR outcome data in a peripartum setting are limited. The objective of this study is to document the efficacy and safety of IR.

Methods

Retrospective study reviewed the records of consecutive patients who underwent peripartum IR from 01/01/2010 until 31/12/2020 in a tertiary academic centre. Patients were divided in a prophylactic and a therapeutic group. Information about interventions before and after IR, and IR specific complications was retrieved. Efficacy was defined by the number of transfusions and additional surgical interventions needed after IR, and safety was assessed by the incidence of IR related complications.

Results

Fifty-four patients, prophylactic group (n = 24) and therapeutic group (n = 30), were identified. In both groups, IR was successful with 1.5 ± 2.9 packed cells transfused post-IR (1.0 ± 2.1 prophylactic vs 1.9 ± 3.3 therapeutic; p = 0.261). Additional surgical interventions were required in n = 5 patients (9.2%), n = 1 (4.2%) in the prophylactic vs. n = 4 (13.3%) in the therapeutic group. Complications were reported in n = 12 patients (22.2%), n = 2 (8.3%) prophylactic vs. n = 10 (33.3%) in therapeutic group. Mostly minor complications, as puncture site hematoma or bleeding, were reported in n = 4 (7.4%). Severe complications as necrosis and metabolic complications were reported in n = 2 patients (3.9%).

Conclusion

IR for prevention and treatment of PPH was highly successful and associated with minor complications.
Identification and validation of the role of ZNF281 in 5-fluorouracil chemotherapy of gastric cancer
Authors: Li Yifan , Zhou Chengying , Wang Guoxu , Xin Huiru , Xiao Yafei , Qin Changjiang
Published: June 2024

Background

The early diagnosis of gastric cancer (GC) and overcoming chemotherapy resistance is challenging. The aberrant expression of zinc finger protein 281 (ZNF281) and the over-activation of the Wnt/β-catenin pathway are oncogenic factors and confer tumor chemoresistance. ZNF281 modulates the Wnt/β-catenin pathway to influence malignant tumor behavior. However, the role of ZNF281 in GC chemotherapy and the relationship with the Wnt/β-catenin pathway have not been elucidated by researchers.

Methods

We explored differences in ZNF281 expression in Pan-cancer and normal tissues, the effect of its expression on prognosis of patients treated with 5-fluorouracil (5-FU). Cox regression was utilized to determine whether ZNF281 is an independent prognostic factor. Enrichment analysis was performed to explore the mechanism underlying ZNF281’s role in 5-FU treatment. We assessed the relationship between ZNF281 and the tumour microenvironment (TME) and combined bulk-RNA and single-cell RNA data to analyse the relationship between ZNF281 and immune infiltration. In vitro experiments verified the effects of ZNF281 knockdown on proliferation, invasion, migration, apoptosis, DNA damage of GC cells with 5-FU treated and the Wnt/β-catenin pathway proteins.

Results

ZNF281 was highly expressed in seven cancers and correlates with the prognosis. It is an independent prognostic factor in 5-FU treatment. ZNF281 correlates with TME score, CD8T cell abundance. ZNF281 is primarily associated with DNA repair and the Wnt/β-catenin pathway. ZNF281 knockdown enhanced the effect of 5-FU on phenotypes of GC cells.

Conclusion

We identified and verified ZNF281 as one of the potential influencing factors of 5-FU treatment in GC and may be associated with the Wnt/β-catenin pathway. Low ZNF281 may contribute to improved 5-FU sensitivity in GC patients.
Intermittend pneumatic venous thrombembolism (VTE) prophylaxis during neurosurgical procedures
Authors: Oberle Linda , Tatagiba Marcos , Naros Georgios , Machetanz Kathrin
Published: June 2024

Background

The management of perioperative venous thrombembolism (VTE) prophylaxis is highly variable between neurosurgical departments and general guidelines are missing. The main issue in debate are the dose and initiation time of pharmacologic VTE prevention to balance the risk of VTE-based morbidity and potentially life-threatening bleeding. Mechanical VTE prophylaxis with intermittend pneumatic compression (IPC), however, is established in only a few neurosurgical hospitals, and its efficacy has not yet been demonstrated. The objective of the present study was to analyze the risk of VTE before and after the implementation of IPC devices during elective neurosurgical procedures.

Methods

All elective surgeries performed at our neurosurgical department between 01/2018–08/2022 were investigated regarding the occurrence of VTE. The VTE risk and associated mortality were compared between groups: (1) only chemoprophylaxis (CHEMO; surgeries 01/2018–04/2020) and (2) IPC and chemoprophylaxis (IPC; surgeries 04/2020–08/2022). Furthermore, general patient and disease characteristics as well as duration of hospitalization were evaluated and compared to the VTE risk.

Results

VTE occurred after 38 elective procedures among > 12.000 surgeries. The number of VTEs significantly differed between groups with an incidence of 31/6663 (0.47%) in the CHEMO group and 7/6688 (0.1%) events in the IPC group. In both groups, patients with malignant brain tumors represented the largest proportion of patients, while VTEs in benign tumors occurred only in the CHEMO group.

Conclusion

The use of combined mechanical and pharmacologic VTE prophylaxis can significantly reduce the risk of postoperative thromboembolism after neurosurgical procedures and, therefore, reduce mortality and morbidity.
Forest management plan pathways for non-industrial private forest owners in Norway: from acquisition to implementation
Authors: Bashir Altamash , Sjølie Hanne K. , Solberg Birger
Published: June 2024

Forest management plans (FMP) are key decision-support tools for forest managers and a central policy instrument in many countries. Despite its pivotal importance in forest management, there is a lack of studies that analyze the acquisition, familiarity and implementation of the FMP. These steps collectively contribute to making FMP a successful decision-support tool and forest policy instrument. We surveyed a sample representative of the population of Norwegian non-industrial private forest (NIPF) owners to quantify the importance of a broad set of factors, including ownership objectives, socio-demographic, property and information sources variables on the FMP pathway, i.e. acquisition of FMP, awareness of its content and implementation of the plans’ proposals. Applying principal component analysis on twelve ownership objectives, we found that most forest owners are multiobjective. We combined conditional classification trees and logistic regression analyses on the FMP pathway to unveil familiarity and use of FMP in forest owner subgroups as well as individual drivers. The results indicate that 37% of Norwegian NIPF owners have a FMP. Among the owners having FMP, 66% have good knowledge of its content and 40% implement its proposals. The strongest variables to predict FMP familiarity and use were previous harvests, productive area, advice about forestry from the public management, knowledge of public support schemes for forestry and perceived relevance of the FMP. We conclude that FMP suppliers, consultants, forestry bureaucracy and policy-makers should emphasize information dissemination and relevance of the FMP to increase its success as a decision-support tool and forest policy instrument.
Catalytic Nanomedicine: Coated bionanocatalysts for Catalytic Antineoplastic activity
Authors: López-Goerne Tessy , Ortiz-Islas Emma , Rodríguez-Reinoso Francisco , Monroy Hugo , Gómez-López Esteban , Padilla-Godínez Francisco J.
Published: June 2024

Glioma tumors are the most common form of central nervous system tumors, and there is a pressing need for innovative methods that can precisely target cancer cells while leaving healthy tissues unharmed. In this study, progressing in the field of Catalytic Nanomedicine, we investigated the cytotoxic effects of a novel class of bionanocatalysts on glioma cancer cells. These bionanocatalysts were constructed from a catalytic matrix of oxides with evenly dispersed superficial copper-coating nanoparticles. This design optimizes both the inherent catalytic characteristics of the matrix and instills cytotoxic properties. The bionanocatalysts coated with copper demonstrated a significant reduction in cancer cell viability when compared to reference bionanocatalysts without the transition metal. We also observed structural damage to the cytoskeleton and alterations in mitochondrial activity. These findings suggest that these pathways are integral to the mechanisms through which these nanostructures execute their bionanocatalytic activities, particularly in breaking chemical bonds. Importantly, our physicochemical analyses verified that the coating with copper species, primarily CuO, did not disrupt the individual structure of the bionanocatalysts: instead, it enhanced their catalytic cytotoxic potential. This research aims to deepen our understanding of the mechanisms underlying this promising antineoplastic treatment and underscore the effectiveness of superficial copper-coating nanoparticles as agents for amplifying the inherent properties of bionanocatalysts through nanocatalysis.
Shea tree (Vitellaria paradoxa C.F. Gaertn.) agroforestry systems in Northern Ghana: population structure, management of trees and impact of below canopy microclimate
Authors: Jepsen Thea , Stopponi Gaia , Jørgensen Niels O. G.
Published: June 2024

The shea tree (Vitellaria paradoxa C.F. Gaertn.) is an important tree species in agroforestry systems in West Africa and shea nuts constitute a fundamental resource for rural livelihoods in this area. This study investigated the sustainability and interactions in agroforestry systems of shea trees around the village Nakpalli in Northern Ghana. The focus of the study was the population structures and densities of shea trees on different land types, below-canopy microclimate and co-cultivation of yams (Dioscorea rotundata (Poir.) J. Miége) under shea tree canopies, and water stress of the trees in the driest season. Shea tree populations are overall well-conserved in this area, but Weibull-distributions of the tree populations and quantification of seedlings showed a lower tree density in both cultivated and fallowed lands, as compared to undisturbed bushlands. Although farmers may deliberately manage the density of larger trees, the low densities of seedlings and saplings indicate that intensified management practices, including shortened fallow periods and intentional clearing of land by fire before sowing, might negatively affect the long-term regeneration of the shea trees. Co-cultivation of yams below shea tree canopies allowed production of 11.5 t/ha as compared to 20.8 t/ha at open field conditions. The lower yields may have been caused by an almost 74% reduction of photosynthetically active radiation below canopies, relative to outside the canopies. Shea trees in the fields, fallows and bushlands had close-to-zero predawn leaf water potentials, indicating low water stress, even in the middle of the dry season. Thus, shea trees are both well-adapted and highly valued in this area, which underlines the importance of conserving this indigenous tree species in the agroforestry systems of northern Ghana.
Intimate Partner Violence and HIV Outcomes Among Women Living with HIV in Durban, South Africa
Authors: Ojeaburu Sheila O. , Dorward Jienchi , Violette Lauren R. , Gibbs Andrew , Shozi Hlengiwe , Sookrajh Yukteshwar , Mhlongo Thobile , Ngobese Hope , Garrett Nigel , Drain Paul K.
Published: June 2024

We examined the impact of past-year intimate partner violence (IPV) on HIV outcomes among women living with HIV (WLHIV) in Durban, South Africa. We assessed past-year IPV using the WHO Violence Against Women Questionnaire. We conducted logistic regression to assess associations between demographic variables and IPV at baseline, and between IPV at baseline and longitudinal HIV outcomes. Among 235 WLHIV, 17% reported past-year emotional, physical, or sexual IPV. At baseline, HIV-disclosure to partner was associated with 4.35-fold odds of past-year IPV (95% CI 1.17–16.10) after controlling for children, education, and harmful alcohol use. In the prospective analysis, IPV was associated with not achieving the co-primary outcome of retention in care and viral suppression in univariate (OR = 2.32, 95% CI 1.04–5.18), but not in the multivariate model. In the context of rapid treatment scale-up, the high burden of IPV among WLHIV needs to be prioritized, with an emphasis on disclosure support.
Men’s Satisfaction with General Health Services is Associated with Future Use of HIV Testing in Malawi: A Community-Representative Survey
Authors: Thorp Marguerite , Balakasi Kelvin , Khan Shaukat , Stillson Christian , van Oosterhout Joep J. , Nichols Brooke E. , Cornell Morna , Dovel Kathryn
Published: June 2024

Across sub-Saharan Africa, men are less likely to know their HIV status than women, leading to later treatment initiation. Little is known about how experiences with general health services affect men’s use of HIV testing. We used data from a 2019 community-representative survey of men in Malawi to understand frequency and cause of men’s negative health service experiences (defined as men reporting they “would not recommend” a facility) and their association with future HIV testing. We conducted univariable and multivariable logistic regressions to determine which aspects of health facility visits were associated with would-not-recommend experiences and to determine if would-not-recommend experiences 12–24 months prior to the survey were associated with HIV testing in the 12 months prior to the survey. Among 1,098 men eligible for HIV testing in the 12 months prior to the survey, median age was 34 years; 9% of men reported at least one would-not-recommend experience, which did not differ by sociodemographics, gender norm beliefs, or HIV stigma beliefs. The factors most strongly associated with would-not-recommend experiences were cost (aOR 5.8, 95%CI 2.9–11.4), cleanliness (aOR 4.2, 95%CI 1.8–9.9), medicine availability (aOR 3.3, 95%CI 1.7–6.4), and wait times (aOR 2.7, 95%CI 1.5-5.0). Reporting a would-not-recommend experience 12–24 months ago was associated with a 59% decrease in likelihood of testing for HIV in the last 12 months (aOR 0.41; 95% CI:0.17–0.96). Dissatisfaction with general health services was strongly associated with reduced HIV testing. Coverage of high-priority screening services like HIV testing may benefit from improving overall health system quality.
Multi-level Factors Associated with HIV Late Presentation with Advanced Disease and Delay Time of Diagnosis in South Carolina, 2005–2019
Authors: Shi Fanghui , Zhang Jiajia , Chen Shujie , Yang Xueying , Li Zhenlong , Weissman Sharon , Olatosi Bankole , Li Xiaoming
Published: June 2024

This study explored individual- and county-level risk factors of late presentation with advanced disease (LPAD) among people with HIV (PWH) and their longer delay time from infection to diagnosis in South Carolina (SC), using SC statewide Enhanced HIV/AIDS Reporting System (eHARS). LPAD was defined as having an AIDS diagnosis within three months of initial HIV diagnosis, and delay time from HIV infection to diagnosis was estimated using CD4 depletion model. 3,733 (41.88%) out of 8,913 adult PWH diagnosed from 2005 to 2019 in SC were LPAD, and the median delay time was 13.04 years. Based on the generalized estimating equations models, PWH who were male (adjusted prevalence ratio [aPR]: 1.22, 95% CI: 1.12 ∼ 1.33), aged 55+ (aPR: 1.76, 95% CI: 1.62 ∼ 1.92), were Black (aPR: 1.09, 95% CI: 1.03 ∼ 1.15) or Hispanic (aPR: 1.42, 95% CI: 1.26 ∼ 1.61), and living in counties with a larger proportion of unemployment individuals (aPR: 1.02, 95% CI: 1.01 ∼ 1.03) were more likely to be LPAD. Among PWH who were LPAD, Hispanic (adjusted beta: 1.17, 95% CI: 0.49 ∼ 1.85) instead of Black (adjusted beta: 0.11, 95% CI: -0.30 ∼ 0.52) individuals had significant longer delay time compared to White individuals. Targeted and sustained interventions are needed for older, male, Hispanic or Black individuals and those living in counties with a higher percentage of unemployment because of their higher risk of LPAD. Additionally, specific attention should be paid to Hispanic individuals due to their longer delay time to diagnosis.
A lightweight CNN-transformer model for learning traveling salesman problems
Authors: Jung Minseop , Lee Jaeseung , Kim Jibum
Published: June 2024

Several studies have attempted to solve traveling salesman problems (TSPs) using various deep learning techniques. Among them, Transformer-based models show state-of-the-art performance even for large-scale Traveling Salesman Problems (TSPs). However, they are based on fully-connected attention models and suffer from large computational complexity and GPU memory usage. Our work is the first CNN-Transformer model based on a CNN embedding layer and partial self-attention for TSP. Our CNN-Transformer model is able to better learn spatial features from input data using a CNN embedding layer compared with the standard Transformer-based models. It also removes considerable redundancy in fully-connected attention models using the proposed partial self-attention. Experimental results show that the proposed CNN embedding layer and partial self-attention are very effective in improving performance and computational complexity. The proposed model exhibits the best performance in real-world datasets and outperforms other existing state-of-the-art (SOTA) Transformer-based models in various aspects. Our code is publicly available at https://github.com/cm8908/CNN_Transformer3.
Modelling impacts to water quality in salmonid-bearing waterways following the introduction of emerald ash borer in the Pacific Northwest, USA
Authors: Maze Dominic , Bond Julia , Mattsson Monte
Published: June 2024

Oregon ash (Fraxinus latifolia Benth.) wetlands and riparian forests are an important economic, cultural, and ecological resource in the Pacific Northwest, USA, and are threatened by the invasive insect, emerald ash borer (Agrilus planipennis Fairmmaire) (EAB). Following the discovery of EAB in Forest Grove, Oregon in June of 2022, it is predicted that EAB-induced ash mortality will alter vegetation communities and modify hydrology of wetlands and streams in the Pacific Northwest. Of primary concern is an increase in solar loading of already degraded waterways and wetlands that support Endangered Species Act-listed salmonids and other cold-water species following canopy dieback of Oregon ash. Our study, which began before the first detection of EAB on the West Coast, models potential impacts of EAB-mediated Oregon ash canopy loss to temperature-related water quality on two waterways in the vicinity of Portland, Oregon. Our results indicate a significant increase in solar loading with likely negative impacts to Endangered Species Act-listed salmonids, other aquatic wildlife, and associated habitat. We forecast greater impacts to these resources outside our study scope and include considerations for entities with water quality-related regulatory obligations.
Invasive black rats menacing endangered lizards
Authors: López-Darias Marta , López-González Mercedes , Padilla David P. , Martín-Carbajal Javier , Piquet Julien C.
Published: June 2024

Despite the pernicious impacts that invasive black rats Rattus rattus have on island ecosystems, little is known about their effect upon insular reptiles, which are a highly vulnerable but pivotal element of island biota. To bring to light these effects, we evaluated the threat posed by R. rattus on the critically endangered Canarian spotted lizard Gallotia intermedia by analyzing its frequency of occurrence on rat feces, estimating rat abundance and density, and correlating these parameters with previous lizard censuses. We genetically detected that 14.96% of all rat feces contained G. intermedia, with 27.27% of individual R. rattus consuming this lizard. Rat density varied from 0.740 ± 0.474 to 2.183 ± 1.137 rats/ha and was correlated with larger declines of G. intermedia between past censuses and those of 2019. These results confirm for the first time that R. rattus consumes and impacts this endemic and endangered lizard species. From a broader perspective, this is one of the first studies detecting rat impact on a large-sized reptile, which calls for further attention to the interaction between invasive rats and a highly vulnerable but essential component of island ecosystems.
Parenting as a Moderator of the Relation Between Child Inhibited Temperament and Anxiety in Western Contexts: A Systematic Review
Authors: Aaron Elizabeth M. , Caley Emma , Kiel Elizabeth J.
Published: June 2024

The literature on the role of parenting in the relation between child inhibited temperament and child anxiety is inconsistent, with some literature supporting a moderating role and some literature supporting alternative (e.g., mediating) roles. A systematic review of the evidence that parenting moderates the longitudinal relation between child inhibited temperament and child anxiety is needed. A systematic review of the literature was conducted in February and March of 2022 and repeated in January of 2024. Ten articles met criteria for inclusion, with 39 moderation analyses of interest among them. All included studies were conducted in Western contexts with predominately White, middle-class families. Thus, the current review can only be generalized to this population. Despite inconsistent findings, some evidence indicated that avoidance-promoting parenting behaviors such as overprotection and overinvolvement moderate the relation between child inhibited temperament and social anxiety symptoms, in particular. There was a lack of evidence that parenting behaviors moderate the relation between child inhibited temperament and anxiety disorders, and that affect-related parenting behaviors (e.g., negativity) moderate the relation between child inhibited temperament and non-social anxiety symptoms. There was mixed evidence regarding the moderating role of control-related parenting behaviors in the relation between child inhibited temperament and non-social anxiety symptoms, with some evidence that encouraging behaviors moderate this relation. Future research is needed to clarify these inconsistent and nuanced findings and investigate this moderation in non-Western, non-White, and low-income populations.
Tail-dependence clustering of time series with spatial constraints
Authors: Benevento Alessia , Durante Fabrizio , Pappadà Roberta
Published: June 2024

We introduce a clustering method for time series based on tail dependence. Such a method also considers spatial constraints by means of a suitable procedure merging temporal and spatial dependence via extreme-value copulas. The cluster composition depends on the choice of the hyper-parameter $$\alpha \in (0,1)$$

α
∈
(
0
,
1
)

used to calibrate the contribution of the spatial dependence to the overall dissimilarity. A novel heuristic approach to select $$\alpha$$
α
based on a suitable connectedness index associated to each cluster of the  partition is proposed.
Structure of the assemblage of fruit-feeding butterflies in a high Andean anthropogenic landscape
Authors: Álvarez Carlos Federico , Freitas André Victor Lucci , Iserhard Cristiano Agra , Giraldo Carlos Eduardo , Uribe Sandra Inés , Marín Mario Alejandro
Published: June 2024

The high Andean mountains are ecosystems subject to high human pressure activities, resulting in disturbed areas increasingly dominating the landscapes. However, there needs to have more knowledge about the contributions of different vegetation coverages and species to global diversity at the local level. For three consecutive years, we studied a guild of fruit-feeding butterflies in four different land covers (cloud forests, paramo, mixed anthropogenic habitats, and cattle pastures) in the northern Andes in Colombia, analyzing the diversity and structure of the butterfly assemblage in the region. The assembly showed significant differences between land covers. The mixed habitat was the most diverse in order q1 (exponential of Shannon entropy) and q2 (inverse of Gini-Simpson dominance index) diversity, and the cloud forest contained the higher abundance and species richness. Abundance decreased from forest to pasture, significantly reducing diversity in pastures, with cloud forest and paramo containing the key endemic species. These results indicate the value of landscape diversity in providing resources and conditions required for the diversity conservation of high Andean butterflies.
Influence of the rate of flow of argon on the optical properties of the MnSmO3 films prepared by magnetron sputtering technique
Authors: Abd El‑Raheem M. M. , Ahmed Mahrous R. , Mohamed Sara A.
Published: June 2024

MnSmO3 thin films were deposited by radio frequency magnetron sputtering method with pure argon flow rate (20, 30, 45, 50, and 60 sccm). The crystalline and morphological structures of MnSmO3 thin films were examined using X-ray diffraction and scanning electron microscopy revealing amorphous nature. Optical properties MnSmO3 thin films showed direct transition and normal dispersion of the refractive index at all rate of flow. The optical energy gap decreased with increasing the rate of flow, whereas the plasma behaved contrary to that of the optical gap. The dispersion energies deduced from Drude models are found to be larger than that of the single-oscillator energies. Non-linear refractive index is found to decrease with increasing the rate of flow. The linear and non-linear optical susceptibilities showed a tendency of decreasing with increasing the rate of flow.
Optimizing alkaline hydrothermal treatment for biomimetic smart metallic orthopedic and dental implants
Authors: Hadady Hanieh , Alam Arefin , Khurana Indu , Mutreja Isha , Kumar Dhiraj , Shankar Mamilla Ravi , Dua Rupak
Published: June 2024

Orthopedic and dental implant failure continues to be a significant concern due to localized bacterial infections. Previous studies have attempted to improve implant surfaces by modifying their texture and roughness or coating them with antibiotics to enhance antibacterial properties for implant longevity. However, these approaches have demonstrated limited effectiveness. In this study, we attempted to engineer the titanium (Ti) alloy surface biomimetically at the nanometer scale, inspired by the cicada wing nanostructure using alkaline hydrothermal treatment (AHT) to simultaneously confer antibacterial properties and support the adhesion and proliferation of mammalian cells. The two modified Ti surfaces were developed using a 4 h and 8 h AHT process in 1 N NaOH at 230 °C, followed by a 2-hour post-calcination at 600 °C. We found that the control plates showed a relatively smooth surface, while the treatment groups (4 h & 8 h AHT) displayed nanoflower structures containing randomly distributed nano-spikes. The results demonstrated a statistically significant decrease in the contact angle of the treatment groups, which increased wettability characteristics. The 8 h AHT group exhibited the highest wettability and significant increase in roughness 0.72 ± 0.08 µm (P < 0.05), leading to more osteoblast cell attachment, reduced cytotoxicity effects, and enhanced relative survivability. The alkaline phosphatase activity measured in all different groups indicated that the 8 h AHT group exhibited the highest activity, suggesting that the surface roughness and wettability of the treatment groups may have facilitated cell adhesion and attachment and subsequently increased secretion of extracellular matrix. Overall, the findings indicate that biomimetic nanotextured surfaces created by the AHT process have the potential to be translated as implant coatings to enhance bone regeneration and implant integration.

Graphical Abstract
18q Deletion Syndrome Presenting with Late-Onset Combined Immunodeficiency
Authors: Hashiguchi Sho , Tomomasa Dan , Nishikawa Takuro , Ishikawa Shuji , Akaike Harumi , Kobae Hidehiko , Shirai Tsuyoshi , Nagao Toshikage , Noma Kosuke , Okada Satoshi , Kamuro Kazuhiro , Okamoto Yasuhiro , Kanegane Hirokazu
Published: June 2024

Patients with chromosome 18q deletion syndrome generally experience hypogammaglobulinemia. Herein, we describe two patients with chromosome 18q deletion syndrome who presented with late-onset combined immune deficiency (LOCID), which has not been previously reported. Patient 1 was a 29-year-old male with 18q deletion syndrome, who was being managed for severe motor and intellectual disabilities at the Yamabiko Medical Welfare Center for 26 years. Although the patient had few infections, he developed Pneumocystis pneumonia at the age of 28. Patient 2, a 48-year-old female with intellectual disability and congenital malformations, was referred to Tokyo Medical and Dental University Hospital with abnormal bilateral lung shadows detected on her chest radiography. Computed tomography showed multiple lymphadenopathies and pneumonia. A lymph node biopsy of the inguinal region revealed granulomatous lymphadenitis, and a chromosomal examination revealed 18q deletion. Array-based genomic hybridization analysis revealed deletion at 18q21.32-q22.3 for patient 1 and at 18q21.33-qter for patient 2. Immune status work-up of the two patients revealed panhypogammaglobulinemia, decreased number of memory B cells and naïve CD4+ and/or CD8+ cells, reduced response on the carboxyfluorescein diacetate succinimidyl ester T-cell division test, and low levels of T-cell receptor recombination excision circles and Ig κ-deleting recombination excision circles. Consequently, both patients were diagnosed with LOCID. Although patients with 18q deletion syndrome generally experience humoral immunodeficiency, the disease can be further complicated by cell-mediated immunodeficiency, causing combined immunodeficiency. Therefore, patients with 18q deletion syndrome should be regularly tested for cellular/humoral immunocompetence.
Including ‘Work as a Treatment Goal’ in the Care for Patients with Chronic Diseases
Authors: Dona Desiree J. S. , Peters Marlies E. W. J. , Senden Theo F. , Bloem Sjaak , Bartstra Herman , Jacobs Marieke T. , Schaafsma Frederieke G. , Jeurissen Patrick
Published: June 2024

Background

The Netherlands faces 60% prevalence of chronic conditions by 2040, impacting societal participation and quality of life. Current clinical care inadequately addresses these consequences, and most hospitals do not integrate occupational health in their care.

Objectives

To develop a generic person- and work-oriented medical care model (WMCM) based on real life experiences with work-oriented care and supporting the chronically ill in active societal participation.

Methods

A qualitative research project with a participative approach in one hospital (November 2019 until March 2020). In an expert meeting, a schematic representation of a work-oriented care model was developed. Subsequent discussion rounds, with professionals from different patient groups, iteratively refined the model to a WMCM.

Results

Consensus was reached after seven rounds of discussion, defining the model’s core elements (1) a combination of biomedical and biopsychosocial approaches, (2) involvement of a clinical occupational physician in the treatment team, (3) a coordinating role for nursing specialists, and (4) incorporation of a work-oriented intervention plan (WoIP) into the treatment plan. Advocating early attention to societal participation, the model emphasises the WoIP and consensus on monitoring indicators. The final goal is a sustainable return to societal participation, considering both quality of life and work.

Conclusion

It is feasible to develop a generic person- and work-oriented care model for patients with chronic illness within a hospital care setting. Collaboration between healthcare professionals and a specialised occupational physician, with a central role for nurses, is deemed crucial.
Return to Work Following Hip or Knee Arthroplasty: A One-Year Prospective Cohort Study in Participants with Direct Referral from Hospital to Occupational Health Care Services
Authors: Kangas Pauliina , Soini Satu , Pamilo Konsta , Kervinen Visa , Kinnunen Marja-Liisa
Published: June 2024

Purpose

In a new Finnish Coordinated Return to Work (CRTW) model, patients are referred to occupational health care after hip or knee arthroplasty. This study evaluated the CRTW model’s effect on return to work (RTW), activities used in occupational health care and in the workplace, and the patient- and work-related factors affecting early RTW.

Methods

209 participants with occupational health care service underwent primary hip (THA) or total/unicondylar knee (KJA) arthroplasty and completed self-reported questionnaires after arthroplasty and at time of RTW. Factors affecting RTW, and the roles of occupational health care and the workplace in RTW were evaluated. Time to RTW was determined as days between the arthroplasty and RTW.

Results

Mean time to RTW was 69 days after THA and 87 days after KJA. For easing RTW, work arrangements were made for 56% of the participants. The most utilized adjustments of work were enabling remote work and arranging limitations in work tasks. Participants with earlier RTW had lower physical workload, higher professional status and motivation to work, less pre-arthroplasty sick leave, and more positive personal expectations about the time to RTW compared to participants with later RTW (p < 0.001 for all). The linear regression and dominance analyses showed participants’ own expectations and pre-arthroplasty sick leave as the strongest factors affecting time to RTW.

Conclusions

The CRTW model seems to shorten time to RTW after THA and KJA. Occupational health care and workplace play important roles in supporting RTW. Patients’ own expectations should be noted when giving pre-arthroplasty information.
National Identity Development Among Minority Youth: Longitudinal Relations with National Fit Perceptions and School Belonging
Authors: Gharaei Nadya , Fleischmann Fenella , Phalet Karen
Published: June 2024

Across Western Europe, immigrant-origin minority youth often struggle to belong socially and to develop national self-identification. Yet, almost no research to-date has asked how these youth perceive the cultural contents of the national identity in their residence country—or rather, to what extent they perceive youth like them to (mis)fit the national identity. The present study addressed this research gap by centering schools as developmental contexts of evolving belonging and national self-identification and newly inquiring into minority youth’s perceptions of national (mis)fit as critical levers of their national identity development. Drawing on data from two annual waves of the Leuven-Children of Immigrants Longitudinal Study (Leuven-CILS), a sample of 942 Moroccan- and Turkish-origin youth (Mage-T1 = 14.98, SD = 1.22; 52% female) in 62 Belgian schools was used. Cross-lagged analysis combined repeated measures of school belonging and national self-identification with vignette measures of the perceived national fit of (imagined) culturally different peers. While school belonging and national self-identification were unrelated over time, earlier perceived national fit uniquely enabled more national self-identification one year later, over and above evolving school belonging. These findings suggest that experiencing belonging in school does not suffice for minority youth to develop national self-identification. Schools may, however, promote national identity development through redefining national identities to include cultural diversity—thereby signaling to minority youth that they can fit the national identity.
Landscape configuration and storm characteristics drive spatial patterns of wind disturbance in boreal forest landscapes
Authors: Kulha Niko , Heikkinen Juha , Holder Jonathan , Honkaniemi Juha , Kuronen Mikko , Laapas Mikko , Suvanto Susanne , Peltoniemi Mikko
Published: June 2024

Context

Wind is an important disturbance in circumboreal forests, and its frequency and severity may change with climate change, highlighting the need to understand the drivers of wind disturbance. Currently, how landscape configuration drives wind disturbance is poorly understood.

Objectives

We investigated whether and how landscape configuration is related to the extent and spatial pattern of wind disturbance, and how these relationships vary between windstorms and thunderstorms.

Methods

We used salvage logging data after 16 storms that occurred in Finland between 2011 and 2021. We placed a total of 301 landscapes, each encompassing an area of 8024 ha, within the storm tracks and used regression models to test how wind disturbance extent, disturbance patch size, number of disturbance patches, and disturbance patch clustering were related to landscape configuration and storm characteristics.

Results

Increasing mean gap size and edge density, including permanent openings (e.g., lakes) and recent harvest gaps, increased disturbance extent, disturbance patch size, and number of disturbance patches. Conversely, increasing mean harvest gap size decreased disturbance patch clustering. Increasing wind speed had the largest contribution to increasing disturbance extent and number of disturbance patches, and decreasing disturbance patch clustering, with the magnitude of the effect varying between windstorms and thunderstorms.

Conclusions

The extent and spatial pattern of wind disturbances varied with landscape configuration and storm characteristics. Disturbance patches were larger in landscapes with large canopy gaps, resulting in a greater disturbance extent, exacerbated by increasing wind speed and thunderstorm development.
Rights, Wronging, and Equality of Status
Authors: Fornaroli Giulio
Published: June 2024

Two problems about rights have received so far little attention. One is the problem of identifying a general value in the practice of rights. The second is to see when, if at all, rights violations wrong the right-holder, in a morally significant sense. In the present essay, I address the first question by investigating the second. I first show that if we commit to the two ideas, common in the contemporary philosophy of rights, that claim-rights always correlate with directed duties and that rights aspire to protect interests of the right-holder, we make it hard to explain why rights violations, in general, wrong right-holders. In the final section, I present what I see as a promising solution to the puzzle. I describe a particular social environment (the society of equals) where interacting with others through rights is indeed valuable because respecting rights communicates that one takes seriously others’ equal moral status. In such a society and only in such a society, I conclude, moral agents are required to treat all rights violations as wrongs perpetrated against the right-holder.
Which ‘Intensional Paradoxes’ are Paradoxes?
Authors: Tennant Neil
Published: June 2024

We begin with a brief explanation of our proof-theoretic criterion of paradoxicality—its motivation, its methods, and its results so far. It is a proof-theoretic account of paradoxicality that can be given in addition to, or alongside, the more familiar semantic account of Kripke. It is a question for further research whether the two accounts agree in general on what is to count as a paradox. It is also a question for further research whether and, if so, how the so-called Ekman problem bears on the investigations here of the intensional paradoxes. Possible exceptions to the proof-theoretic criterion are Prior’s Theorem and Russell’s Paradox of Propositions—the two best-known ‘intensional’ paradoxes. We have not yet addressed them. We do so here. The results are encouraging. §1 studies Prior’s Theorem. In the literature on the paradoxes of intensionality, it does not enjoy rigorous formal proof of a Gentzenian kind—the kind that lends itself to proof-theoretic analysis of recondite features that might escape the attention of logicians using non-Gentzenian systems of logic. We make good that lack, both to render the criterion applicable to the formal proof, and to see whether the criterion gets it right. Prior’s Theorem is a theorem in an unfree, classical, quantified propositional logic. But if one were to insist that the logic employed be free, then Prior’s Theorem would not be a theorem at all. Its proof would have an undischarged assumption—the ‘existential presupposition’ that the proposition $$\forall p(Qp\!\rightarrow \!\lnot p)$$

∀
p
(
Q
p

→

¬
p
)

exists. Call this proposition $$\vartheta $$
ϑ
. §2 focuses on $$\vartheta $$
ϑ
. We analyse a Priorean reductio of $$\vartheta $$
ϑ
along with the possibilitate $$\Diamond \forall q(Qq\!\leftrightarrow \!(\vartheta \!\leftrightarrow \! q))$$

◊
∀
q
(
Q
q

↔

(
ϑ

↔

q
)
)

. The attempted reductio of this premise-pair, which is constructive, cannot be brought into normal form. The criterion says we have not straightforward inconsistency, but rather genuine paradoxicality. §3 turns to problems engendered by the proposition $$\exists p(Qp\wedge \lnot p)$$

∃
p
(
Q
p
∧
¬
p
)

(call it $$\eta $$
η
) for the similar possibilitate $$\Diamond \forall q(Qq\!\leftrightarrow \!(\eta \!\leftrightarrow \! q))$$

◊
∀
q
(
Q
q

↔

(
η

↔

q
)
)

. The attempted disproof of this premise-pair—again, a constructive one—cannot succeed. It cannot be brought into normal form. The criterion says the premise-pair is a genuine paradox. In §4 we show how Russell’s Paradox of Propositions, like the Priorean intensional paradoxes, is to be classified as a genuine paradox by the proof-theoretic criterion of paradoxicality.