bluuebunny/crossref_metadata_2025 huggingface dataset:
EGFR Kinase Inhibiting Amino-enones for Breast Cancer; CADD Approach
Authors: Gladies Raymond Mohanraj Deena , Alagumuthu Manikandan , Chellam Subha , Suresh Kumar Abishek , Nagaraj Poojari Tejaswini , Suresh Kumar Jeevitha , Subramaniam Palaniraja
Published: February 2024

Background::

The Computer-Aided Drug Discovery (CADD) approach was used to develop a
few Epidermal Growth Factor Receptor (EGFR) kinase inhibitors. EGFR kinase expression is
highly associated with genomic instability, higher proliferation, lower hormone receptor levels,
and HER2 over-expression. It is more common in breast cancer. Thus, EGFR Kinase is one of
the main targets in discovering new cancer medicine.

Objective::

To computationally validate some amides substituted β-amino enones as EGFR inhibitors
and to carry out associated in vitro anticancer agents

Methods::

We used tools such as molecular docking, MD simulations, DFT calculations, and
ADMET predictions in silico to establish a preliminary SAR. In vitro, we used BT474
(ER+HER2+) and MCF-7 (ER-HER2) cell lines along with normal breast cell epithelial cells
(MFC-10a) for anticancer studies and EGFR kinase inhibition assay studies. As the Reactive
Oxygen Species (ROS) plays the main role in cancer development, we also analyzed the antioxidant
potentials of these compounds.

Results::

Among the family of eleven amides substituted (Z)-β-amino enones (5a-k), compounds
5b, 5c, 5g, and 5h showed valuable in silico and in vitro bio-activity. Remarkably, the in-silico
results almost coincided with in vitro study results.

Conclusion::

We recommend compounds 5b, 5c, 5g, and 5h for pre-clinical and clinical evaluation
to establish them as future cancer therapeutics
Screening of Candidate Inflammatory Markers of Epithelial Cells in Hepatocellular Carcinoma Based on Integration Analysis of TCGA/ICGC
Databases and Single-cell Sequencing
Authors: Huang Zupin , Li Zhuokai , Lv Xinliang , Tan Wei
Published: February 2024

Background:

Hepatocellular Carcinoma (HCC) is closely linked to inflammatory
reactions, with chronic liver diseases acting as major risk factors. In the inflammatory microenvironment,
repeated damage and repair of liver cells lead to genetic mutations, abnormal proliferation,
and tumorigenesis.

Objective:

This study aimed to investigate the expression profile of specific cell clusters under
inflammatory stimulation in HCC and identify potential therapeutic drugs.

Methods:

Comprehensive analysis of HCC transcriptome data and single-cell sequencing data
from TCGA, ICGC, and GEO databases was conducted to explore the specific molecular mechanisms
of epithelial cells. Virtual screening of natural compounds in the ZINC database and in
vitro cell experiments were performed to identify drugs that regulate the expression of inflammatory
factors in epithelial cells.

Results:

Analysis of the single-cell dataset revealed cell clusters closely associated with HCC,
notably Epithelial cells, Hepatocytes, MSC, and iPS cells, with Epithelial cells playing a pivotal
role in HCC development. Further investigation of TCGA data unveiled 83 differentially
expressed genes (DEGs) related to inflammatory responses in HCC. Intersection analysis
of DEGs in epithelial cells and HCC DEGs identified 12 common DEGs, including ADRM1,
ATP2B1, FZD5, GPC3, KIF1B, KLF6, LY6E, MET, NAMPT, SERPINE1, SPHK1, and
SRI. Prognostic analysis revealed that CCL7, GPR132, ITGB8, PTAFR, SELL, and VIP were
influential in the survival prognosis of HCC. A prognostic model based on the expression
levels of these genes demonstrated an increased risk of HCC associated with higher differential
expression of inflammatory response genes. Additionally, molecular dynamics simulations
indicated that compounds NADH and Deferoxamine formed stable docking models
with the inflammatory protein VIP, suggesting their potential as candidates for targeted
therapy.

Conclusion:

Inflammatory factors CCL7, GPR132, ITGB8, PTAFR, SELL, and VIP influence
the inflammatory cascade response in HCC epithelial cells, and their expression correlates
with the survival prognosis of HCC patients. Interfering with VIP expression effectively
suppresses proliferation, migration, and invasion of HCC cells, as well as inhibiting the
occurrence of inflammatory cascade reactions, thus slowing down the progression of hepatocellular
carcinoma. Furthermore, compounds NADH and Deferoxamine have the potential to
target and bind to the inflammatory protein VIP, highlighting their relevance in potential HCC
treatment.
Investigating the Relationship between COVID-19 In-hospital Death and
Acute Kidney Injury
Authors: Haghighi Ramin , Fereyduny Nikoo , Oghazian Mohammad Bagher , Haghighi Ashkan , Bigdeli Amir , Sahebkar Amirhossein
Published: February 2024

Introduction:

Coronavirus Disease 2019 (COVID-19) can induce multiorgan failure, including
acute kidney injury (AKI), which is associated with a poor prognosis. Some of these patients
develop proteinuria, hematuria, and elevated serum creatinine, therefore some require hemodialysis.
This study aimed to investigate the association between in-hospital death due to COVID-19 and the
incidence of AKI.

Methods:

In a retrospective study, the available data of patients who died because of COVID-19
from April 1 to September 22, 2020 in a referral hospital was investigated using the case census
method.

Results:

A total of 190 patients who died of COVID-19 were evaluated. Of these, 111 (58.42%) had
AKI, with 108 (56.84%) being male. The mean age of the subjects was 66.16±15.43 years old. The
mean time from hospital admission to death was about 9 days in all patients. Although not statistically
significant, the findings showed that patients who developed AKI died sooner. The most frequent
underlying diseases were hypertension [n= 101 (53.16%)] and diabetes [n= 44 (23.16%)]. Moreover,
a higher proportion of subjects with AKI as compared to those without AKI were admitted to the
intensive care unit (ICU), and had abnormal proteinuria profile (p-value=0.045 and 0.025, respectively).

Conclusion:

The incidence of AKI was 58.42% in patients who died from COVID-19 disease.
Moreover, abnormal proteinuria and ICU admission were significantly higher in COVID-19 patients
with AKI than in those without AKI.
Reconstruction identitaire dans La carte postale d’Anne Berest)
Authors: Coca Beatriz
Published: February 2024

In her novel The Postcard, Anne Berest proposes the reconstruction of the identity of her maternal ancestors, the Rabinovitchs. The pretext which relaunches this search for identity and its fictionalization is none other than an anonymous postcard received in 2003 in his parents’ home. This card presents the image of the Opera and on the back are written four first names: Ephraïm, Emma, Noémie, Jacques, who died at Auschwitz in 1942. In 2019, Anne Berest and her mother set out to elucidate the questions surrounding this postcard; the investigation required by the fictionalization of biographical and chronological data is coupled with a quest for identity and memory. Under the guise of a thriller, the story presents the story of the Rabinovitchs doomed to exodus and, therefore, to new foundations, driven by the significant events of the 20th century. In the conquest of the right to likeness, two distinct levels are felt: the other’s view of the protagonists and the Frenchness of the writer. Finally, the fictional devices allow him to show that the past is migrant, as well as the desire for belonging and linguistic and sociocultural resemblance.
Sobre o que podemos não salvar
Authors: Evangelista Lúcia
Published: February 2024

Is the world really worth saving? And what is this world that urges to be saved? This essay considers both these questions and seeks to reflect on how art, especially poetry, can articulate them.
ANALYSIS OF BRAKING SYSTEM ON ENERGY SAVING CARS "SAKERA", MECHANICAL ENGINEERING WORK, UM SURABAYA
Authors: Saifullo Saifullo , Batutah Moh Arif , Rizaly Anastas , Ponidi Ponidi , Kusnanto Hadi , Sofana Ilyas
Published: February 2024

A braking system in a vehicle has a very important role in maintaining the safety of drivers and passengers, and preventing accidents. The brake system functions to reduce speed (slow down) and stop the vehicle. A good braking system provides safety and comfort for the drivers. Therefore, it is necessary to design the right braking system for “Sakera” car. In this study, an analysis and calculation of the braking system was carried out to determine the required braking force at a speed of 50 km/hour and other speeds in a distance of 15 m. The data taken in this study was the specification of the braking system used in the Sakera car. The braking system analysis was carried out on flat roads with varying speeds, namely 30 km/h, 35 km/h, 40 km/h, 45 km/h, and 50 km/h with a distance of 15 m for braking. The conclusions of the analysis were obtained, namely the greater the speed of Sakera's car, the greater the braking force to stop the car, the hydraulic pressure on the hose, and the force of the driver's feet, as well as the braking force needed on road conditions with a slope angle of 20º, which is 839.362 N.
OPTIMIZATION OF SHELL AND TUBE HEAT EXCHANGER DESIGN WITH INCLINED BAFFLES
Authors: Rahman Aulia , Winarto Winarto , Siswanto Eko
Published: February 2024

Shell and tube heat exchanger (STHeX) design development continues to be carried out to increase the effectiveness of a system. One way is to investigate the optimal baffle design. The new structure of STHeX with Inclined-Segmental Baffles is further investigated. The experiment was carried out using the numerical method Computing Fluid Dynamics (CFD) software with three-dimensional modeling. The results show that the heat change coefficient value is lower than conventional STHeX, However, the pressure drop value is reduced quite significantly. Therefore, it is necessary to know the overall heat transfer coefficient value per pressure loss (U/DeltaP). Hence, we get U/DeltaP values of 0.9 and 0.68 for STHeX with Inclined-Segmental Baffle and conventional STHeX, respectively. Thus, there is a significant increase ranging from 37-34%. It is concluded that STHeX with Inclined-Segmental baffles increases the U/DeltaP value significantly compared to conventional STHeX.
Modification Of Coso Internal Control For The Economy Of Indonesian Corn Emblems SMEs
Authors:   Faculty of Computer Science, University of Brawijaya, Kariyoto Kariyoto
Published: February 2024

This study aims to determine the application of raw material control and internal support according to COSO and COSO modifications for Micro, Small and Medium Enterprises (MSMEs). The object under study is the Nusantara Corn Chips SMEs. The research method used in this study is a qualitative method with the type of case study. Based on observations, it is known that the internal control of raw materials and supporting ingredients for Nusantara corn chips is still very simple. Based on the survey, it shows that in the control of raw and supporting materials at Emping Jagung Nusantara, there are 10 principles that are appropriate and 7 that are not in accordance with the COSO internal control components. In accordance with this, there are several principles that are not relevant for MSMEs, such as the absence of a board or audit committee as a supervisor for MSMEs Emping Jagung Nusantara. The above basis is irrelevant and takes into account the principles of cost and benefit, the principles of COSO, so that COSO internal controls are formed for MSMEs.
Strategy for Handling Victims of Sexual Violence and Bullying by Unit Layanan Terpadu Kekerasan Seksual dan Perundungan (ULTKSP) Faculty of Vocational University of Brawijaya
Authors:   fakultas Vokasi, Universitas Brawijaya, Susilowati Susilowati
Published: February 2024

The phenomenon of sexual violence and bullying that occurs on campus is often carried out by educated people, both fellow students, lecturers and education staff. With the increase in sexual violence that occurs in tertiary institutions, it will directly or indirectly have an impact on the less than optimal implementation of the Tridharma of Higher Education and reduce the quality of higher education. University of Brawijaya established Unit Layanan Terpadu Kekerasan Seksual dan Perundungan (ULTKSP), a unit that functions as an integrated service provider for victims of Sexual Violence and/or Bullying which is managed by University of Brawijaya and carried out by the Faculty, Postgraduate and Study Programs Outside the Main Campus. The strategy used to handle victims of sexual violence and/or bullying, namely services; Inspection; Protection; Recovery; Accompaniment; Prosecution of Perpetrators and Supervision.
Mumbul Park and Lele Village: Tourism and Creative Economy Potential in Bojonegoro Regency
Authors:   Department of Nutrition, Faculty of Health Sciences, Universitas Brawijaya, Rahmawati Widya
Published: February 2024

Kalianyar, Kalirejo and Pacul villages were three villages in the Bojonegoro Regency that have tourism and creative economy potential. Kalianyar Village had Mumbul Park tourist destination, while Kalirejo and Pacul Villages have the potential in the form of community fishponds which can become tourist destinations and producers of catfish. This Strategic Community Service Activity aimed to strengthen facilities and improve community skills in utilising their potential. These community service activities included: 1) Revitalization of Mumbul Park; 2) Training on making souvenirs; 3) Improvement of fish pond and foodstalls facilities; 4) Training on catfish feed from Moringa leaves; 5) Training on making flossed catfish; 6) Improvement of catfish pond facilities and installation of biopores; 7) Catfish cultivation in buckets training; 8) Training on making catfish nuggets and chicken dimsum; 9) Socialization of food diversification and fish-eating movement; 10) Socialization of applications for halal certification.
Business Model Value Chain: Competitiveness Entrepreneurial Retailing Traditional Second-hand Fashion
Authors: Sakti Trenggono Pujo
Published: February 2024

The research aims to utilize the business model value chain to analyze the competitiveness of entrepreneurial retailing of traditional second-hand fashion that potential strategies in Jember. Design qualitative research method case studies with single-case to in-depth interviews with owner/managers retail. The results showed formulating a business model retailing traditional second-hand fashion provides a new lens for competency area, and behavior focus on goal orientation that correlates to reducing surplus waste products and apparel through resale rather than being allocated to the waste system. Thus, research findings utilize the business model value chain on based-oriented: a) sorting, refurbishing, and cleaning as operations, b) innovative redistribution as outbound logistics, c) word-of-mouth as advertising, and d) fitting room simple as service. Therefore, revelatory of the competitiveness highlights the core competency of retailing traditional second-hand fashion on rethinking reducing post-consumer textile waste and further contributing to learning existing business practices.
PRISLAMISM, RADICALIZATION AND DERADICALIZATION IN CANADA
Authors: Shaikh Mubin
Published: February 2024

On November 13, 2023, Professor Mubin Shaikh presented Prislamism, Radicalization, and Deradicalization in Canada at the West Coast Security Conference. The presentation was followed by a question-and-answer period with questions from the audience and CASIS Vancouver executives. The key points discussed were that Prislamism, thought of as a route to radicalization, is a blend of Islamic theory and concepts that advocates for violence toward institutions of incarceration. The prison systems in both Muslim and Western nations provide a breeding ground for radicalization through both their physical conditions and the social dynamics of custody. Combating radicalization in prisons requires robust training and a steadfast adherence to the law on the part of practitioners.

 

Received: 12-11-2023

Revised: 01-26-2024
JOINT INTEROPERABILITY AND THE IMPORTANCE OF STRATEGIC COORDINATION GROUPS
Authors: Price Liam
Published: February 2024

On November 14, 2023, Director General Liam Price, International Special Services, International Policing, Royal Canadian Mounted Police (RCMP), presented Joint Interoperability and the Importance of Strategic Coordination Groups for this year’s West Coast Security Conference. The key points discussed were that the nature of criminality is evolving to increasingly encompass cross-border, technologically adept, and highly adaptable strategies, and policing organizations must advance and expand their tactics and training to create effective solutions. This involves creating common legal frameworks, emphasizing shared policing values and enhancing information sharing capabilities.

 

Received: 12-18-2023

Revised: 01-26-2024
DEVELOPING THEORY ON THE INSURGENT USE OF INTELLIGENCE
Authors: Strachan-Morris David
Published: February 2024

On November 15, 2023, Dr. David Strachan-Morris, presented on Developing Theory on the Insurgent Use of Intelligence for this year’s West Coast Security Conference. The presentation was followed by a question-and-answer period with questions from the audience and CASIS Vancouver executives. The key points discussed were uncertainty towards the global threat environment, counterintelligence strategies in vulnerable regions, and the treatment of intelligence as a public good.

 

Received: 12-30-2023

Revised: 01-26-2024
BALANCING NATIONAL SECURITY INTERESTS WITH PRIVACY, THE CHARTER AND RULE OF LAW: BUILDING CHECKLISTS INTO OPERATION PLANNING
Authors: Dubois Justin
Published: February 2024

On November 17, 2023, Justin Dubois, Executive Director and General Counsel of the Office of the Intelligence Commissioner, presented Balancing National Security Interests with Privacy, the Charter and Rule of Law: Building Checklists into Operation Planning for this year’s West Coast Security Conference. The presentation was followed by a question-and-answer period with questions from the audience and CASIS Vancouver executives. The key points discussed were the Intelligence Commissioner Act, the role of the Intelligence Commissioner in providing quasi-judicial review of certain activities of intelligence agencies, and the Intelligence Commissioner’s use of the principles of necessity, proportionality, and reasonableness to guide its decision-making process.

 

Received: 01-04-2024

Revised: 01-29-2024
Victor Hugo e a tradução. Todo um “caminho de pedra” que conduz ao paraíso
Authors: Chantal Louchet
Published: February 2024

O objetivo é seguir a evolução do próprio pensamento de Victor Hugo sobre a conceção da tradução e do tradutor. De facto, em 1819, Victor Hugo ficou indignado com uma tradução de Homero em verso em língua francesa: “É monstruoso e insustentável”, declarando que “uma tradução em verso de qualquer pessoa, por qualquer pessoa parece-[lhe] absurda, impossível e quimérica”, sugerindo a priori que Victor Hugo é um defensor da intraduzibilidade. Na sua juventude, Victor Hugo entendia que qualquer tradução era proibida, um tabu, dando toda a importância ao próprio autor. Mas o seu ponto de vista irá evoluir com o tempo. O trabalho desenvolvido pelo seu filho François-Victor Hugo, de 1858 a 1866, trar-lhe-á um novo horizonte no campo da tradução. Labor severo, revalorizando assim a tarefa do tradutor, percorrendo um caminho árduo, mas estimulante. Tributário da sua época, com Victor Hugo, é todo um processo de renovação de ideias do discurso francês sobre a tradução que nos é entregue. O objetivo deste artigo é mergulhar no universo de Victor Hugo a fim de clarificar esta sua perspetiva evolutiva ao longo do século XIX. Fá-lo-emos analisando os seus escritos cronologicamente, desde as obras da primeira juventude, até às obras do seu exílio.
Ursula Wölfel, obras publicadas, livros traduzidos e retraduzidos en España
Authors: Springer Andrea H.L.
Published: February 2024

Este trabajo es un preludio de nuestro proyecto de tesis doctoral en la que investigamos la recepción de Ursula Wölfel (1922–2014), autora alemana de literatura infantil y juvenil en una doble vertiente: diacrónicamente, a partir de 1963, a través de los medios de comunicación y la crítica literaria y, sincrónicamente, mediante un estudio de caso con estudiantes, como destinatarios primarios. El propósito de este artículo es recopilar la obra traducida, editada y publicada de Ursula Wölfel en España. Durante esta parte de la investigación hemos realizado búsquedas en las bases de datos de las bibliotecas nacionales alemana y española, en la de libros editados en España, el Catálogo Colectivo de Bibliotecas Públicas, así como en el catálogo de Red Automatizada de Bibliotecas de Castilla y León, siempre en línea. Procedimos a comparar la información disponible y unificarla. Durante el proceso nos percatamos de que no solo se han traducido libros de Ursula Wölfel en primera edición, sino que también hay reediciones, que han sido reilustradas, pero mantienen el texto original; e incluso existen retraducciones reilustradas. Ello nos lleva a reflexionar brevemente sobre el concepto de retraducción y sobre si esta es una oportunidad para mantener vivo el legado de Ursula Wölfel.
Protocolo de prueba física en agua en la Escuela Militar de Cadetes
Authors: Perdomo-Becerra Kevin Santiago , Pérez-Cuesta Jeffry Santiago , Ramírez-Hernández German , Umbarila-Espinosa Luz  Marina
Published: February 2024

El presente artículo expone el protocolo de prueba física de agua a alumnos de la Escuela Militar de Cadetes, con miras a mejorar el nivel y rendimiento físico en medio acuático de los futuros oficiales del Ejército Nacional de Colombia. La metodología presenta enfoque mixto: cuantitativo, al recoger datos de la primera prueba física 2023-II; cualitativo, al considerar elementos descriptivos de las pruebas, y documental y de campo, al examinar la realidad donde ocurren los hechos. El protocolo busca indicarle al alumno la correcta ejecución de los ejercicios; servirle de guía para mejorar su condición física; subsanar los índices de bajo rendimiento en pruebas en medio acuático de la Esmic, y demostrar la importancia de estas en la vida militar.
Exploring the Regenerative Potential of Stem Cells for Treating Eye Diseases: A Review of the New Findings
Authors: Akbaribazm Mohsen
Published: February 2024

The escalating prevalence of vision loss due to eye diseases has instigated a quest for innovative therapies, given that conventional approaches often fall short in repairing and regenerating damaged eye tissues, particularly the retina. Stem cell-based interventions have emerged as a promising avenue, with numerous studies in animal models and human trials exploring their potential to enhance visual acuity. Beyond addressing conditions like age-related macular degeneration (AMD) and diabetic retinopathy (DR), stem cell therapies demonstrate efficacy in treating genetic disorders such as retinitis pigmentosa (RP). In severe eye damage necessitating regeneration, stem cells play a pivotal role, leveraging their regenerative capabilities. Noteworthy is the transplantation of retinal pigment epithelial (RPE) cells derived from embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), showcasing promising results in preclinical models and clinical studies, leading to improved retinal function without severe side effects. Mesenchymal stem cells (MSCs) have successfully treated optic neuropathy, RP, DR, and glaucoma, yielding positive clinical outcomes. The safety of adult stem cells, particularly MSCs derived from adipose tissue or bone marrow, has been firmly established. This review highlights significant advancements in utilizing human ESC-derived retinal pigmented epithelium and iPSCs for treating eye injuries. While cell-based therapy is relatively nascent, with numerous clinical trials pending review, stem cells' regenerative potential and clinical applications in addressing eye diseases offer substantial promise. This study aims to comprehensively examine the applications of stem cells in the context of eye diseases and their potential role in regenerative medicine.
Formulasi Dan Uji Fisik Sediaan Lip Balm Dari Ekstrak Biji Alpukat (Persea americana Mill) Sebagai Pelembab
Authors: Hayati Mih , Nusantari Candra Saka , Shinta Wulandari
Published: February 2024

Indonesia adalah negara dengan kekayaan alam dan sumber daya alam yang sangat melimpah, baik sumber daya yang berasal dari pertanian, perkebunan, atau pertambangan. Buah alpukat (Persea americana Mill) adalah salah satu tanaman yang banyak tumbuh di berbagai daerah di Indonesia, dan dapat dimanfaatkan dalam bidang kosmetik. Bagian dari buah alpukat yang jarang dimanfaatkan adalah biji alpukat. Biji alpukat mengandung nilai gizi yang tidak kalah dibandingkan dengan bagian daging alpukat, salah satunya adalah kandungan vitamin E yang dimanfaatkan sebagai bahan pelembab. Pada penelitian ini, ekstrak biji buah alpukat akan dimanfaatkan sebagai salah satu komponen penyusun dari pelembab bibir, untuk mengetahui apakah ada pengaruh perbedaan konsentrasi terhadap stabilitas ekstrak biji buah alpukat sebagai lip balm, dan mengevaluasi variasi konsentrasi dengan stabilitas fisik paling baik, dengan variasi 0%, 3%, 6%, 9%. Ekstrak biji buah alpukat dibuat dengan metode homogenisasi (pencampuran), uji sifat fisik yang dilakukan meliputi uji organoleptik (warna, bau, dan tekstur), uji homogenitas, uji pH, dan uji titik leleh. Dari hasil penelitian yang telah dilakukan diperoleh bahwa biji buah alpukat dapat dimanfaatkan sebagai pelembab bibir (lip balm) dan memenuhi syarat kestabilan sifat fisik.
Development and Usability Testing of a Mobile App–Based Clinical Decision Support System for Delirium: Randomized Crossover Trial
Authors: Wang Jiamin , Ji Meihua , Han Yuan , Wu Ying
Published: February 2024

Background

The 3-Minute Diagnostic Interview for Confusion Assessment Method–Defined Delirium (3D-CAM) is an instrument specially developed for the assessment of delirium in general wards, with high reported sensitivity and specificity. However, the use of the 3D-CAM by bedside nurses in routine practice showed relatively poor usability, with multiple human errors during assessment.

Objective

This study aimed to develop a mobile app–based delirium assessment tool based on the 3D-CAM and evaluate its usability among older patients by bedside nurses.

Methods

The Delirium Assessment Tool With Decision Support Based on the 3D-CAM (3D-DST) was developed to address existing issues of the 3D-CAM and optimize the assessment process. Following a randomized crossover design, questionnaires were used to evaluate the usability of the 3D-DST among older adults by bedside nurses. Meanwhile, the performances of both the 3D-DST and the 3D-CAM paper version, including the assessment completion rate, time required for completing the assessment, and the number of human errors made by nurses during assessment, were recorded, and their differences were compared.

Results

The 3D-DST included 3 assessment modules, 9 evaluation interfaces, and 16 results interfaces, with built-in reminders to guide nurses in completing the delirium assessment. In the usability testing, a total of 432 delirium assessments (216 pairs) on 148 older adults were performed by 72 bedside nurses with the 3D-CAM paper version and the 3D-DST. Compared to the 3D-CAM paper version, the mean usability score was significantly higher when using the 3D-DST (4.35 vs 3.40; P<.001). The median scores of the 6 domains of the satisfactory evaluation questionnaire for nurses using the 3D-CAM paper version and the 3D-DST were above 2.83 and 4.33 points, respectively (P<.001). The average time for completing the assessment reduced by 2.1 minutes (4.4 vs 2.3 min; P<.001) when the 3D-DST was used.

Conclusions

This study demonstrated that the 3D-DST significantly improved the efficiency of delirium assessment and was considered highly acceptable by bedside nurses.
Barriers to Postdischarge Smartphone App Use Among Patients With Traumatic Rib Fractures
Authors: Berrigan Margaret T , Beaulieu-Jones Brendin R , Baines Rachel , Berkowitz Seth , Evans Heather , Brat Gabriel A
Published: February 2024

Rib fractures commonly result from traumatic injury and often require hospitalization for pain control and supportive pulmonary care. Although the use of mobile health technology to share patient-generated health data has increased, it remains limited in patients with traumatic injuries. We sought to assess the feasibility of mobile health tracking in patients with rib fractures by using a smartphone app to monitor postdischarge recovery. We encountered patient, institutional, and process-related obstacles that limited app use. The success of future work requires the acknowledgment of these limitations and the use of an implementation science framework to effectively integrate technological tools for personalized trauma care.
mHealth Apps for the Self-Management of Low Back Pain: Systematic Search in App Stores and Content Analysis (Preprint)
Authors: Zhou Tianyu , Salman David , McGregor Alison
Published: February 2024

BACKGROUND

With the rapid development of mobile health (mHealth) technology, many health apps have been introduced to the commercial market for people with back pain conditions. However, little is known about their content, quality, approaches to care for low back pain (LBP), and associated risks of use.

OBJECTIVE

The aims of this research were to (1) identify apps for the self-management of LBP currently on the market and (2) assess their quality, intervention content, theoretical approaches, and risk-related approaches.

METHODS

The UK iTunes and Google Play stores were initially searched for apps related to the self-management of LBP in May 2022. A repeat search in June 2023 was conducted to ensure that any relevant new apps developed in the last year were incorporated into the review. A total of 3 keywords recommended by the Cochrane Back and Neck Group were used to search apps “low back pain,” “back pain,” and “lumbago.” The quality of the apps was assessed by using the 5-point Mobile App Rating Scale (MARS).

RESULTS

A total of 69 apps (25 iOS and 44 Android) met the inclusion criteria. These LBP self-management apps mainly provide recommendations on muscle stretching (n=51, 73.9%), muscle strengthening (n=42, 60.9%), core stability exercises (n=32, 46.4%), yoga (n=19, 27.5%), and information about LBP mechanisms (n=17, 24.6%). Most interventions (n=14, 78%) are consistent with the recommendations in the National Institute for Health and Care Excellence (NICE) guidelines. The mean (SD) MARS overall score of included apps was 2.4 (0.44) out of a possible 5 points. The functionality dimension was associated with the highest score (3.0), whereas the engagement and information dimension resulted in the lowest score (2.1). Regarding theoretical and risk-related approaches, 18 (26.1%) of the 69 apps reported the rate of intervention progression, 11 (15.9%) reported safety checks, only 1 (1.4%) reported personalization of care, and none reported the theoretical care model or the age group targeted.

CONCLUSIONS

mHealth apps are potentially promising alternatives to help people manage their LBP; however, most of the LBP self-management apps were of poor quality and did not report the theoretical approaches to care and their associated risks. Although nearly all apps reviewed included a component of care listed in the NICE guidelines, the model of care delivery or embracement of care principles such as the application of a biopsychosocial model was unclear.
Effect of Synthesis Temperature on Adsorbent Performance of Blending Anionic and Cationic Gels in Divalent Metal Ions Adsorption
Authors: Ningrum Eva Oktavia , Suprapto Suprapto , Altway Saidah , Triastuti Warlinda Eka , Hamzah Afan , Surono Agus , Taji Lulu Sekar , Ardiansyah Erlangga
Published: February 2024

In this study, the anionic and cationic gels were synthesized separately using copolymerization between N-isopropylacrylamide (NIPAM) and acrylic acid or chitosan through a polymerization reaction using N,N'-methylenebisacrylamide (MBAA) as a cross-linker with various monomer concentrations and synthesis temperature. The anionic and cationic gels were blended to minimize inter-intra particle association and to improve the adsorption ability. The FTIR analysis found that the synthesis of the NIPAM-co-acrylic acid and NIPAM-co-chitosan gels was successfully carried out, indicating no presence of a vinyl group in the functional group. The result showed that the ion adsorption amount of Pb2+ ions blending gels increased significantly, almost twice compared to the adsorption before blending. The adsorption amount of Pb2+ ions increased with increasing the gel synthesis temperature. The adsorption amount follows the order of Pb2+ > Fe2+ > Ni2+. The adsorption amount of Pb2+ tends to decrease with increasing sedimentation volume. The higher the synthesis temperature, the larger the porous diameter formed. These results demonstrate that blending gel of NIPAM-co-chitosan and NIPAM-co-acrylic acid is a feasible alternative for removing heavy metal ions owing to its good adsorption performance.
Fast and Simple Au3+ Colorimetric Detection Using AgNPs and Investigating Its Reaction Mechanism
Authors: Rachmawati Faathir Al Faath , Rusdiarso Bambang , Kunarti Eko Sri
Published: February 2024

One of the precious metals that has numerous applications is gold. Although it is non-toxic and biocompatible, the oxidized form, Au3+, is toxic and can cause damage to human organs. Detection of Au3+ becomes a necessary and interesting topic to be conducted. Colorimetric analysis using metal nanoparticles such as silver nanoparticles (AgNPs) can analyze metal ions more simply, sensitively, and selectively than traditional methods. In this research, AgNPs were synthesized using polyvinyl alcohol (PVA) and ascorbic acid as stabilizers and reducing agents. The interaction between Au3+ and AgNPs selectively decreased the absorbance intensity of AgNPs and altered the color of colloidal AgNPs from yellow to colorless. These two phenomena indicated a redox reaction between Au3+ and AgNPs, leading to the decomposition of AgNPs. The decomposition of AgNPs (the proposed mechanism) was confirmed by TEM images and UV-vis spectra. The decrease in AgNPs’ absorbance intensity correlated linearly with the increase in added Au3+ concentration. The calibration curve of ∆A versus Au3+ ion concentration yielded LOD and LOQ of 0.404 and 1.347 μg/mL, respectively.
Design, Synthesis of New Imidazolium-1,2,3-triazole Hybrid Derivatives as Antimicrobial Agents
Authors: Muttaleb Ameer Salem , Berto Nardeen Adnan , Mamoori Sahar Adeeb , Alaridhee Zaman Abdalhussein Ibadi , Obaid Ehab Kareem , Radhi Ali Jabbar
Published: February 2024

New imidazolium salts with 1,2,3-triazole rings (rm1-rm5) were prepared in the current work using a design-driven synthetic procedure scheme. By using analytical techniques such as NMR, IR and spectral information, the chemical structures of target synthesized products were identified using results that were discovered in perfect accord with their assigned structures. The microorganism used in the current study were bacterial strains of Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Bacillus subtilis and Micrococcus luteus, as well as the fungal strains of Aspergillus niger and Candida albicans. All the end products were estimated for their antibacterial activity. The values for the minimum inhibitory concentration (MIC) were confirmed by comparison to the widely used antibiotics fluconazole and ciprofloxacin as control drugs. Particularly, the compounds (rm5) and (rm4) showed observable antibacterial activity. These compounds might offer a brand-new place to start when looking for new antibacterial medications.
Controllable Cetrimide – Assisted Hydrothermal Synthesis of MoFe2O4 and Coupling with Al2O3 as an Effective Photocatalyst for Decolorization of Indigo Carmine Dye
Authors: Hameed Mohammed Ali , Ahmed Luma Majeed
Published: February 2024

This research focuses on the MoFe2O4 nanoparticles synthesized via the hydrothermal method in the presence of positive surfactant- Cetrimide (CT) as a template and stabilizer. This is vital to prevent the agglomeration and reducing its activity. The mean crystal sizes of MoFe2O4 and its composite with alumina system were observed to be 23.97 and 47.41 nm, respectively. The shapes of MoFe2O4 and its composite are nanoplate and like-popcorn nanoparticles. The EDX spectra demonstrated that the MoFe2O4 and its composite are truly synthesized with high purity. The FTIR proved the MoFe2O4 is normal spinel. Based on the Tauc equation, band gaps were measured and found to be 2.78 and 4.05 eV for MoFe2O4 and its nanocomposite. The photo decolorization efficiency (PDE) of indigo carmine dye (IC) using MoFe2O4 nanoparticles and its nanocomposite was discovered to be 90.84 and 91.50%, respectively, at pH 5.3, 10 °C for 50 min. This photoreaction obeys the pseudo-first order, exothermic, spontaneous, and negative activation energy, that attitude to the multi-step occurs in chain reactions. This behavior depends on the speed of the binding step of the dye with Fe3+, Mo6+, or Al3+ in the crystal lattice of MoFe2O4 nanoparticle and its nanocomposite.
Energy Efficiency of the Carbonate Hydroxyapatite Nanoparticle Synthesis Using Microwave Heating Treatment and Its Effect on Material Characteristics
Authors: Aziz Saifuddin , Pranowo Harno Dwi , Ana Ika Dewi , Yusuf Yusril
Published: February 2024

This work aimed to study the energy efficiency of the synthesis process of carbonated hydroxyapatite (CHA) nanoparticles using microwave heating treatment and its effect on material characteristics. Microwaves can provide heat quickly, so it is expected to increase the efficiency of CHA synthesis through the heat provided. The CHA nanoparticles were synthesized using precipitation and heated using a microwave oven. The unheated and hydrothermal-heated precipitation methods were also conducted for comparison purposes. The microwave-heated precipitations were done at 270 W for 0.05, 0.10, and 0.15 h, while the hydrothermal-heated precipitations were done at 100 °C for 1, 2, and 3 h. The CHA materials were characterized using an infrared spectrophotometer, X-ray diffractometer, and electron microscope. The X-ray diffractogram and infrared spectra confirmed that the synthesized materials had a hydroxyapatite crystal phase with a CO32− functional group in their spectra. Microscopic images revealed that the materials were nanometer-sized grain aggregates. The heat treatment and duration increased the material characteristics, i.e., crystallinity, crystallite, and grain size. The CHA with microwave heat treatment had the highest crystallinity and crystallite size. The electrical energy calculation revealed microwave heating had better energy efficiency than hydrothermal heating.
Molecular Docking and Molecular Dynamic Investigations of Xanthone-Chalcone Derivatives against Epidermal Growth Factor Receptor for Preliminary Discovery of Novel Anticancer Agent
Authors: Kurniawan Yehezkiel Steven , Yudha Ervan , Nugraha Gerry , Fatmasari Nela , Pranowo Harno Dwi , Jumina Jumina , Sholikhah Eti Nurwening
Published: February 2024

Epidermal growth factor receptor (EGFR) is found to be overexpressed in cancer cells as it controls angiogenesis, cell signaling, and proliferation mechanisms. Therefore, EGFR has been known as a common target for the initial screening of new anticancer agents. Either xanthone or chalcone has been evaluated as the anticancer agents, and their activity strongly depends on the type and position of the attached functional group. Therefore, molecular hybridization between xanthone and chalcone could yield novel anticancer agents through the EGFR inhibition mechanism. Herein, a series of xanthone-chalcone derivatives with hydrogen-bond-acceptor or hydrogen-bond-donor substituents at ortho, meta, and para positions was evaluated as the EGFR inhibitor. Thirty-seven xanthone-chalcones were designed and docked in the active site of EGFR. Compared to the native ligand, pristine xanthone-chalcone gave a 1.215× stronger binding energy and a 13.97× lower binding constant. Compound 3SH was found to be the most promising candidate due to its strongest binding energy (−9.71 kcal/mol) and the lowest binding constant (0.08 µM). Furthermore, molecular dynamic studies demonstrated that complex EGFR-3SH was stable for 100 ns simulation. These in silico investigations show that the xanthone-chalcone derivative is a promising novel anticancer agent to be examined through in vitro and in vivo assays.
RESISTIN GENE POLYMORPHISMS: POTENTIAL BIOMARKER FOR ORAL SQUAMOUS CELL CARCINOMA
Authors: TANDON DIVYA
Published: February 2024

Objective: The objective of the work is to study the association between Resistin Gene polymorphisms and susceptibility of Oral Squamous Cell carcinoma.
Methods: In the present study, we scrutinize the connection between four genetic polymorphisms present in RETN gene with the susceptibility, progression, and clinical outcome of OSCC among 200 OSCC patients and 200 healthy controls.
Results: The results of the study reveal that among 260 smokers, the risk of developing OSCC is significantly more among the subjects having history of using betel quid in comparison to those who are not habitual users of betel quid.
Conclusion: The study reveals that patients with OSCC exhibiting G/A heterozygous genotype of RETN rs3219175 polymorphism have lesser risk for developing high-grade tumor compared to the patients with G/G homozygotes in North Indian population.
The Value of Political Status in a Liberalizing China
Authors:   Binghamton University, Acker Kevin
Published: February 2024

Because political party membership could potentially confer large economic benefits, economists have increasingly turned their attention to the role of political and social status in one’s life. The Chinese Communist party is the biggest political party in the world, and members are often motivated to join for economic reasons. Previous studies examine the relationship between Communist party membership and earnings and find positive correlation but this correlation may be partly or totally spurious, thereby generating upwards-biased estimates of the importance of political party membership – political party membership is likely to be correlated with a variety of other variables, which may well drive the correlation between political party membership and earnings. Using a 1993 housing dataset, this paper estimates the causal effect of Chinese party membership on monthly earnings in two major cities in China by employing a more robust estimation technique than previously used. I contribute to the existing literature by estimating the true causal effect of Communist party membership on wages with a propensity score matching technique, a quasi-experimental method which mimics a randomized control trial by constructing statistically similar control and treatment groups. I find that, on average, membership in the Communist party of China increases monthly earnings by 9 percent.
Performance Study of a Mems Low-Noise Sound Pressue Gradient Microphone Under an AC Bias
Authors:   Binghamton University, Michelson Jonathan
Published: February 2024

An AC bias was introduced into microelectromechanical system (MEMS) low-noise sound pressure gradient microphone by Miles, Cui, Su and Hormentcovschi (2014), and its implications for the device's noise performance and directivity readings are discussed. The schematic involved demodulation of the microphone output with external circuitry, and subsequent computer software analysis of the microphone and circuitry outputs. Although insights into noise improvement were frustrated due to subpar noisy components used in the demodulation circuitry, the simultaneous measuring of the microphone's varying directivity patterns was shown to be achievable with this AC bias scheme.
Challenging Linguistic Superiority Through Social Attitudes: Language Complexities of the Ukrainian Diaspora in the United States
Authors:   Binghamton University, Pinchuk Anna
Published: February 2024

The English language in the United States has a strong legacy of linguistic imperialism that started with bans on the use of languages spoken by indigenous people in the early 1800s. The assumptions behind those policies were that the English language was civilized and progressive, while all other languages were barbaric and improper. In this paper, I examine how the historic language policies in the United States continue to create barriers in non-native speakers’ success and achievement in social and political spheres. I proceed by discussing the English-only policies and native language bans that started the legacy of English superiority in the United States. Secondly, I examine their impact on society at large, focusing on cultural stereotypes and attitudes toward non-native English speakers, and their influence on non-native individuals’ inability to achieve the American Dream and be exemplary citizens. Thirdly, I explore how such social attitudes create feelings of inferiority as well as shame and refusal to speak in individuals’ native languages. Fourthly, I discuss a case study of Ukrainian Diaspora in the United States, and Ukrainians’ complex relationship with language policies in Ukraine and the United States. I conclude with how a more pluralistic and cross-cultural approach to linguistic acceptance and how ethnic language studies could improve relations within the Ukrainian Diaspora and society at large.
Nontraditional Students: An Exploratory Study of College Students Raising Families
Authors:   Binghamton University, Barnes Mindy
Published: February 2024

Research on nontraditional students is lacking, and studies that do exist tend to view nontraditional students as a single group. In response to this issue, I conducted a study focusing on Binghamton University and SUNY Broome students who were in their twenties, married, non-married but living with a partner, and/or raising children. Snowball sampling was used to recruit participants for an interview. The interview questions were open-ended and focused on the students’ educational experiences, as well as their views on how their academic career affected their familial roles and vice versa. A total of five students were interviewed. All of the participants encountered some form of role conflict, were stressed, and felt like outsiders on campus. Some faced financial burdens, had little physical and sometimes emotional support in the home, and did not know what services were available to them on campus. The married and non-married cohabiting students felt that school often interfered with their ability to be a good partner. The parenting students often encountered conflicting school and childcare schedules. All of the participants claimed time management is key, with family obligations coming first. Binghamton University and its faculty were seen as less accommodating than SUNY Broome and its faculty. These students will continue to be marginalized if their needs are not addressed.
Efficacy of Occipital Neuralgia Pain Management Injections
Authors:   Binghamton University, McDonough Samantha
Published: February 2024

This study examined the efficacy of one treatment option for chronic headache pain caused by occipital neuralgia (ON). The treatment is an injection containing a mixture of local anesthetic Marcaine and corticosteroid Depo-Medrol. The efficacy was determined according to the treatment’s impact on each patient’s pain level and quality of life, assessed via phone questionnaire. Electronic medical records (EMRs) were accessed, using the Epic EMR system, for adult patients who received at least one injection for the treatment of ON. Of 27 patients fitting the study criteria, 19 were successfully contacted, and 18 chose to participate in the study. This treatment was found to decrease a patient’s pain level, on average, from 4.7/5.0 to 2.0/5.0. This quantitative result, along with patient testimonies and other qualitative information gathered through the questionnaire, leads to the conclusion that these injections are an effective option for relief of ON symptoms.