bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of machine learning algorithms to identify people with low bone density
Authors: Xu Rongxuan , Chen Yongxing , Yao Zhihan , Wu Wei , Cui Jiaxue , Wang Ruiqi , Diao Yizhuo , Jin Chenxin , Hong Zhijun , Li Xiaofeng
Published: April 2024

Background

Osteoporosis is becoming more common worldwide, imposing a substantial burden on individuals and society. The onset of osteoporosis is subtle, early detection is challenging, and population-wide screening is infeasible. Thus, there is a need to develop a method to identify those at high risk for osteoporosis.

Objective

This study aimed to develop a machine learning algorithm to effectively identify people with low bone density, using readily available demographic and blood biochemical data.

Methods

Using NHANES 2017–2020 data, participants over 50 years old with complete femoral neck BMD data were selected. This cohort was randomly divided into training (70%) and test (30%) sets. Lasso regression selected variables for inclusion in six machine learning models built on the training data: logistic regression (LR), support vector machine (SVM), gradient boosting machine (GBM), naive Bayes (NB), artificial neural network (ANN) and random forest (RF). NHANES data from the 2013–2014 cycle was used as an external validation set input into the models to verify their generalizability. Model discrimination was assessed via AUC, accuracy, sensitivity, specificity, precision and F1 score. Calibration curves evaluated goodness-of-fit. Decision curves determined clinical utility. The SHAP framework analyzed variable importance.

Results

A total of 3,545 participants were included in the internal validation set of this study, of whom 1870 had normal bone density and 1,675 had low bone density Lasso regression selected 19 variables. In the test set, AUC was 0.785 (LR), 0.780 (SVM), 0.775 (GBM), 0.729 (NB), 0.771 (ANN), and 0.768 (RF). The LR model has the best discrimination and a better calibration curve fit, the best clinical net benefit for the decision curve, and it also reflects good predictive power in the external validation dataset The top variables in the LR model were: age, BMI, gender, creatine phosphokinase, total cholesterol and alkaline phosphatase.

Conclusion

The machine learning model demonstrated effective classification of low BMD using blood biomarkers. This could aid clinical decision making for osteoporosis prevention and management.
Be sensei, my friend: Aikido training with a remotely controlled proxy trainer
Authors: Suzuki Takashige , Uhde Alarith , Nakamura Takuto , Narumi Takuji , Amemiya Tomohiro , Kuzuoka Hideaki
Published: April 2024

Contact sports such as Aikido are preferred to be trained in person with an experienced trainer, as the attempts of remote training before and during the COVID-19 pandemic failed to reproduce the quality of the in-person training benefiting from the trainer’s physically present body. To address this issue of replicating in-person experience remotely, we proposed “Sensei possession,” an xReality-based training method for contact sports in which the trainer remotely guides a person who performs the physical interaction with the trainee on behalf of the real trainer in real-time. In this study, to test the effectiveness of “Sensei possession” on training performance and examine the concerns about its possible side effects on motivation, we conducted a between-participants experiment with an Aikido training task [N = 10 pairs (20 people)]. We compared the groups with or without live feedback on the proxy trainers under our hypothesis that live feedback would enhance trainees’ performance gain. As a result, the trainees in the group with live feedback on proxy trainers had more performance gain than those without live feedback, and no indication of negative effects on motivation was shown. We discussed our results concerning the previous research on micro-adaptive training and reported technical insights to improve the design of Sensei possession further.
Development of sustainable tourism in the BRICS countries
Authors:   High school of management Peoples’ Friendship University of Russia named after Patrice Lumumba, Moscow, Russia, Zlatovchena N. , Zeveke O. Yu. ,   High school of management Peoples’ Friendship University of Russia named after Patrice Lumumba, Moscow, Russia
Published: April 2024

The article discusses aspects of adaptation of sustainable development goals in tourism of the BRICS countries. An analysis of the main components of sustainable tourism was carried out in the context of the Russian Federation, Brazil, China, India, and South Africa.
Current state of medical tourism services in the Moscow agglomeration
Authors:   Graduate School of Management, People’s Friendship University of Russia named after Patrice Lumumba, Moscow, Motik V. A. , Zeveke O. Yu. ,   Graduate School of Management, People’s Friendship University of Russia named after Patrice Lumumba, Moscow
Published: April 2024

The article discusses the main problems of providing services in the Moscow agglomeration. An assessment of the current situation regarding the provision of medical tourism services was carried out. The characteristics of internal and external environment for the implementation of medical tourism services, directions for using existing opportunities to prevent threats have been identifi
South Korea as a promising cinema tourism destination
Authors:   Graduate School of Management, People’s Friendship University of Russia named after Patrice Lumumba, Moscow, Sahakyan A. A. , Zeveke O. Yu. ,   Graduate School of Management, People’s Friendship University of Russia named after Patrice Lumumba, Moscow
Published: April 2024

This article examines the factors that prove that the country is becoming a promising destination for film tourism in the world. Currently, South Korea attracts an increasing number of tourists from all over the world. In the country, in addition to standard types of tourism, new holiday destinations are becoming popular. Thanks to the Korean Wave and the Korean film industry in particular, the country is emerging as an attractive destination for film tourists. The purpose of the work was to study the potential of South Korea as a new center for film tourism.
Perfil autístico e funcional de crianças com TEA, recém-matriculadas em uma APAE
Authors: Gonçalves Maria Fernanda , Esteves Vilela Nayane , Afif Rezende Pollyana Heliane , Dos Reis Luciana Maria , Silva Santos Adriana Teresa , Ribeiro Rosário Lívia Maria
Published: April 2024

Introdução. O Transtorno do Espectro Autista (TEA) caracteriza-se por déficits na comunicação e interação social, que causam prejuízos à funcionalidade do indivíduo. Objetivo. Traçar o perfil autístico e funcional de crianças com TEA, recém ingressas em uma Associação de Pais e Amigos dos Excepcionais. Método. Pesquisa transversal, realizada na Fundação Varginhense de Assistência aos Excepcionais (FUVAE), em Varginha-MG. Foram recrutadas crianças matriculadas entre os meses de agosto de 2022 a fevereiro de 2023. Foram aplicados um questionário contendo variáveis sociodemográficas, a escala Childhood Autism Rating Scale, para classificação dos níveis de autismo e o Inventário de Avaliação Pediátrica de Incapacidades - Testagem Computadorizada Adaptativa (PEDI-CAT), para análise funcional. Os dados foram tratados e foi aplicado o teste de normalidade de Shapiro Wilk e correlação de Pearson. O nível de significância adotado foi de p<0,05. Resultados. Foram selecionados 10 participantes, com idade média de 4,10 anos, classificados com autismo leve. Referente ao escore contínuo do PEDI-CAT, o domínio responsabilidade foi mais acometido. A amostra possui desempenho funcional esperado para a idade em todas as habilidades avaliadas pelo PEDI-CAT, através do escore normativo. Não houve correlação entre níveis de autismo e desempenho funcional. Conclusão. A amostra possui perfil funcional esperado para faixa etária, em relação às crianças típicas, no que concerne aos itens: atividades diárias, mobilidade e atividades sociais/cognitivas. Entretanto, a responsabilidade se constitui como o aspecto funcional mais acometido, de acordo com o escore contínuo do PEDI-CAT.
Le cimetière de Jebel Sahaba (site 117, Nubie) : nouvel examen des traces de violences interpersonnelles
Authors: Dias-Meirinho Marie-Hélène , Crevecoeur Isabelle , Antoine Daniel , Bon François
Published: April 2024

The debate on the traces of prehistoric interpersonal violence is heavily reliant on the early 1960s excavations of the Late Pleistocene cemetery of Jebel Sahaba (Nubia) by F. Wendorf. The publication of his work remains a key reference on the subject. However, no integrative study of the traces of violence left on the human remains was undertaken to better understand the extent of the phenomenon identified at this prehis-toric site. Founded by several research programs in 2013, this present reassessment has allowed for a fully integrated analysis of all of the human remains curated/held at the British Museum in London. These detailed studies have been combined with an evaluation of the lithic assemblage associated with each grave. The study reveals further evidence of trauma and demonstrates that violence was not restricted to adult males – both sexes were affected as well as children. This article also highlights differences in funerary prac-tices, particularly with the presence of individual, double, multiple, or successive burials.
Le portail FranceArchives
Authors: Restif Manonmani
Published: April 2024

Agrégateur national pour les archives françaises, le portail FranceArchives est, depuis sa mise en ligne en mars 2017, une porte d’entrée vers un réservoir de métadonnées archivistiques qui s’enrichit au fur et à mesure de l’adhésion de services publics et privés d’archives français. Site de référence pour l’information professionnelle sur les archives, il est avant tout chargé d’offrir un accès fédéré aux instruments de recherche en archives, à tout utilisateur quel que soit son profil, mais aussi de valoriser les collections et les activités des services d’archives. Œuvrant comme un outil de décloisonnement et de rediffusion d’informations, le portail intègre les instruments de recherche produits par ses contributeurs, en extrait les éléments d’indexation pour les transformer en autorités agent, lieu et sujet dans une optique tendant vers un modèle de données entités/ relations. Ces entités dotées d’identifiants pérennes sont enrichies par des alignements vers des référentiels et bases de connaissance partagés, harmonisées et groupées. Ces travaux d’amélioration de la qualité des données doivent faire de FranceArchives le portail de référence pour les archives françaises dans le web de données liées à destination des internautes, mais aussi de ses partenaires qui peuvent récupérer et réutiliser les données enrichies à leur profit.
Comment accompagner les usagers ? L’expérience du service de questions et de réponses Eurêkoi
Authors: Lamotte Caroline
Published: April 2024

Inflation de l’information sur le web et inflation éditoriale suscitent un certain désarroi des personnes en recherche d’information. Un accompagnement des publics du web paraît nécessaire. Mais quelle médiation mettre en place ? Le service de questions / réponses Eurêkoi, qui constitue aussi un réseau, se positionne à un double niveau : une réponse à toute question, mais également une médiation pour aider l’usager à mieux appréhender la méthode de recherche documentaire et les modes d’accès aux ressources comme de garantie de leur fiabilité. Eurêkoi reste néanmoins toujours en réflexion sur le positionnement du service en matière de délai de réponse, d’adéquation des outils ainsi que de modalité d’accompagnement. Face à des usages en évolution, le service, qui n’a lieu d’être que par cette adéquation aux besoins, doit se montrer capable de se renouveler.
Archives et techniques : retour du corps, retour du lieu
Authors: Cuer Georges
Published: April 2024

En pensant le matériau archivistique comme appréhendable par une toile de données qui peuvent être traitées directement ou indirectement par des machines, on peut facilement oublier qu’il est d’abord une constellation en expansion constante de fonds hybrides très partiellement en ligne malgré de considérables réalisations et qu’il importe d’abord de localiser. Un retour critique sur les définitions des archives données par les philosophes contemporains – obérées par l’absence de toute analyse sociale – ou par le législateur et les ouvrages de la pratique, limitées celles-ci par leur objet normatif et utilitariste, permet de prendre à revers nombre d’idées reçues sur une numérisation généralisée des archives, possible ou souhaitable, qui serait un cas particulier de la numérisation du monde.

Le présent texte se veut une apologie sans retenue des archives comme conglomérats de textes et d’objets, «qui prennent leur sens dans une série matérielle objective » (Anheim), sont situés dans le temps et l’espace des sociétés et ne sont pas seulement des textes ou des témoignages ; une apologie également des salles de lecture et d’une conception humaine, sensible, de l’approche des archives. La référence à Francis Ponge marque le souvenir d’une oeuvre inclassable incitant à se mettre à l’écoute du monde comme une symphonie, par l’attention portée à «quelques pêches sur une assiette » , «la serviette-éponge » au lavabo du restaurant, une chèvre…

Vouée à la popularisation des inventaires regardés comme les chevaux de trait de l’archivistique, l’entreprise qui a abouti au portail Online archives of California mérite toute notre attention. Elle a permis d’articuler efficacement l’accès aux archives en ligne et un balayage global des fonds eux-mêmes, qui les débordent. Sa commande «browse » (browse collections, browse institutions, browse maps), croisée avec la commande search qui nous est plus familière, permet de signaler d’ensemble les originaux là où on les conserve. L’évocation du portail californien s’accompagne ici de plusieurs propositions de dispositifs informatiques adaptés au cas des archives françaises.
Le Grand équipement documentaire du Campus Condorcet. Réunir archives et collections documentaires
Authors: Groudiev Stéphanie , Le Brech Goulven
Published: April 2024

Le Grand équipement documentaire du Campus Condorcet a ouvert l’ensemble de ses espaces en décembre 2021. Instrument au service de la recherche et outil de travail quotidien des chercheuses et chercheurs, le GED associe dans une synergie étroite des collections éditées, qu’elles soient imprimées ou numériques, et des archives. Ces dernières étaient auparavant conservées aussi bien dans les services archives des établissements membres du Campus Condorcet, que dans les centres et bibliothèques de recherche des unités qui le rejoignent, où elles côtoyaient déjà les collections documentaires. Tout dans le bâtiment et son offre de services est donc conçu pour faciliter dialogue et fluidité entre collections et archives : mutualisation des espaces de consultation, formations croisées des archivistes, documentalistes et bibliothécaires, développement d’interfaces de recherche communes… La construction de ce nouveau bâtiment a été l’occasion de s’interroger sur les fondamentaux du service rendu, sur l’enjeu du passage à l’échelle de fonctionnements existants dans des structures de plus petite taille, et sur la mutualisation possible tant en termes de compétences, d’espaces que de services. L’enjeu bâtimentaire s’est doublé d’une ambition environnementale spécifique : entièrement bioclimatique, le GED fonctionne sans climatisation, favorisant inertie et brassage d’air dans l’ensemble de ses espaces.
Le design de services, au service des archives (l’expérience des Archives municipales de Saint-Étienne)
Authors: Françon Sophie , Longin Cyril
Published: April 2024

Les Archives municipales et métropolitaines de Saint-Étienne sont engagées dans un projet de nouveau bâtiment, dont la livraison est prévue fin 2025. Dans une ville où le design tient historiquement une place importante, les Archives s'appuient sur le design de service à travers une assistance à maîtrise d'usage (AMU) intégrée à la maîtrise d'œuvre. Cette expérience en cours porte essentiellement sur la salle de lecture dont les enjeux sont nombreux (mutualisation, dimension citoyenne de l''équipement et anticipation sur les usages). Le designer interroge le fonctionnement et les pratiques et tente d''apporter des solutions. La révolution ? Non, mais davantage diversifier l''offre, donner le choix, entrer dans une démarche culturelle et pas seulement de travail. Qui a dit tiers-lieu ?
La conservation des archives historiques du groupe BNP Paribas, d’un bâtiment à l'autre
Authors: Osseland Gauthier
Published: April 2024

Archiver, c’est notamment conserver, et conserver dans de bonnes conditions. Les archives historiques de BNP Paribas ont été constituées au fur et à mesure des années par la concentration d’entités. Leur regroupement puis leur déménagement sur un même site en novembre 2019 parachève une histoire parfois mouvementée. Les modalités de conservation ont été variées mais aussi variables selon les époques et selon les entités. Les politiques à l’égard du patrimoine documentaire n’ont pas toujours été identiques. De même, si la constitution de centres d’archives n’a pas été mise en œuvre avant l’entre-deux-guerres, c’est surtout grâce aux politiques de décentralisation et d’aménagement du territoire qu’est mise en œuvre la centralisation des archives à l’échelle nationale. Ainsi, chaque entité se dote d’un centre qui sert notamment à la conservation des archives historiques. Avec les transformations des vingt dernières années, ces documents ont été déménagés trois fois. Mais la décision, en 2018, de les transférer de Combs-la-Ville, en banlieue parisienne, vers le site historique de Taden, commune limitrophe de Dinan en Bretagne, tend à prouver que le groupe a la volonté d’investir pour la conservation de son patrimoine documentaire dans des conditions optimales comme l’avait entrepris la Banque de Paris et des Pays-Bas dès la fin des années 1920. Retour sur un continuel transfert.
Quand un bâtiment d’archives se transforme en lieu d’exposition
Authors: Joulia Romain , Leiser Carine
Published: April 2024

Après huit décennies de bons et loyaux services (1890-1972), le pavillon des Archives départementales, édifice installé dans la cour d’honneur de la préfecture du Var (devenue sous-préfecture en 1974), aurait pu sombrer dans l’oubli ou faire l’objet de réutilisations hasardeuses. Il a longtemps été présenté comme une référence par le ministère de l’Instruction publique. C’était sans compter sur la volonté du département du Var de créer un établissement culturel d’exception à l’est de son territoire. Positionné sur une artère centrale, ce bâtiment aux proportions avantageuses a fait l’objet d’une réhabilitation soignée pour aboutir à la création d’un hôtel départemental des expositions. Sur trois niveaux, des salles à la scénographie étudiée ont vocation à accueillir des expositions temporaires d’envergure sur la thématique de l’histoire et des civilisations. Grâce à cet ambitieux projet et la proximité de la médiathèque et des Archives départementales, Draguignan offre un véritable potentiel d’animation culturelle partagée pour la collectivité.
Un nouveau bâtiment pour les Archives nationales du Luxembourg
Authors: Kirps Josée
Published: April 2024

Après des années d’attentes et de revirements, le Conseil de gouvernement du Grand-Duché de Luxembourg décida, au mois de mai 2016, d’inscrire le projet de construction d’un nouveau bâtiment pour les Archives nationales sur la liste des grands projets d’infrastructures à soumettre à la Commission du contrôle de l’exécution budgétaire et de charger le Fonds Belval à entamer les études préliminaires d’APS et d’APD et de finaliser le projet de loi y afférent. Au cours de la séance publique du 23 juillet 2020, la Chambre des députés a adopté le projet de loi relative à la construction et à l’équipement d’un nouveau bâtiment pour les Archives nationales, et à l’aménagement des alentours. Implanté sur l’ancien site industriel Esch-Belval, dans le sud du pays, à 20 km de la capitale, le nouveau bâtiment s’étend sur quelque 16 000 m 2 et se compose de trois volumes qui se différencient par leurs fonctions et leur architecture : le volume abritant les surfaces de dépôts, le volume abritant les fonctions administratives, les locaux logistiques ainsi que les espaces publics de consultation et enfin le volume tampon. Le bâtiment est conçu comme un bâtiment à énergie positive et met en œuvre des matériaux écologiques et des techniques constructives à faible empreinte environnementale ainsi que des concepts d’économie circulaire notamment par l’emploi de matériaux recyclables et/ou recyclés.
Au-dessous du volcan de la Soufrière, les Archives départementales de la Guadeloupe. Les anciens bâtiments
Authors: Jullien Benoît
Published: April 2024

Ajoutées aux risques volcaniques et sismiques et plus encore aux fréquents cyclones, les conditions climatiques de la Guadeloupe et des îles de la Caraïbe – une chaleur et une humidité permanentes – ont rendu plus aigües les difficultés posées par la conservation physique des documents et plus incertaines les réponses apportées à ce défi. L’exemple des bâtiments dévolus aux Archives coloniales puis aux Archives départementales de la Guadeloupe a paru significatif de la manière, conventionnelle ou innovante, dont on a progressivement formulé les enjeux et pris en compte dans leur ampleur les spécificités matérielles de la conservation du patrimoine archivistique guadeloupéen. Outre les difficultés liées à la précarité des espaces dévolus aux archives, ce premier article souligne l’absence persistante d’une gestion organisée des documents avant la transformation en départements des «vieilles colonies » de la Guadeloupe, de la Guyane, de la Martinique et de La Réunion et aux premiers effets de la départementalisation qui entraîne la création officielle d’un service départemental d’archives en 1951 et son installation à Basse-Terre dans une caserne désaffectée.
En quête de nouvelles expériences aux archives : visites insolites et jeux de lieu(x)
Authors: Wacrenier Thibault
Published: April 2024

Dans le prolongement d’un travail de recherche sur les activités ludiques aux archives, l’article démontre que les services d’archives sont des espaces qui peuvent s’adapter à des propositions culturelles insolites et ludiques, peu compatibles au premier abord avec les missions de conservation. La volonté des archivistes de moderniser l’image de leur métier auprès des citoyens est démontrée à travers une présentation de différents types d’expériences permettant de découvrir d’une autre manière les lieux où sont conservés les documents d’archives. La plupart du temps, ces animations sont reliées à l’univers des archives puisque les problématiques logistiques et les enjeux de conservation sont des points d’attention essentiels pour leur conception au même titre que le contenu didactique qui se rapporte aux missions des archivistes. L’étude questionne également la pertinence de ces actions, qui sortent de l’ordinaire, et l’adhésion qu’elles peuvent susciter auprès des usagers, des pouvoirs publics et des archivistes eux-mêmes.
L’imbrication des voix dans les Métamorphoses d’Apulée
Authors: Dalbera Joseph
Published: April 2024

The aim of this paper is to examine the different narrative voices that occur in Apuleius’ novel, that alternate or overlap in the Metamorphoses. After having shown how the arrangement of these voices structurally shapes the novel, we will try to describe the syntactic and enunciative processes used by the narrator to insert the characters’ words in his narrative, reported speeches oscillating between imitation and representation.
La guerre civile en 49 avant J.-C. : Étude d’histoire militaire
Authors: Le Bohec Yann
Published: April 2024

During the first year of the civil war, the Roman could see two good armies and two great generals. Caesar had less soldiers, but soldiers militarily well educated by the Gallic War. Superiority of Caesar became evident when he conquered first Italy and then Spain. To secure the roads for logistics and information, he had to besiege Marseille ; this city made an alliance with Pompey.
A Landscape of Control ? Aeneid 8 and Environmental Agency
Authors: Seider Aaron M.
Published: April 2024

Dans cet article, je m’inspire des travaux du champ de l’écocritique pour examiner comment Énéide 8 soulève des questions sur l’organisation de l’environnement. Trois groupes de passages mettent en évidence la relation des personnages avec le monde qu’ils habitent : la défaite d’Hercule contre Cacus ; deux présages naturels livrés à Énée ; et la visite de Pallantée par Évandre. Dans chacun de ces cas, l’engagement des humains dans leur environnement montre comment ils tentent de le contrôler à la fois physiquement et mentalement. Ici, je soutiens qu’Énéide 8 met simultanément en évidence ces aspirations de maîtrise tout en révélant la futilité de telles tentatives. Alors même que les personnages de l’Énéide prennent le contrôle du paysage et en tirent des avantages, les perspectives changeantes du récit et de la focalisation temporelle de l’épopée soulignent que ce contrôle n’est que temporaire et a souvent un prix.
Varron, Ennius et l’étymologie
Authors: Margelidon Cécile
Published: April 2024

The focus of this article is to understand why, in the seventh book of the De Lingua Latina, the Latin grammarian Varro severely criticizes Ennius for having used two etymological wordplays. Which is the scope of this scanty blame on the tragedian ? We will try to perceive the way Varro understood and detected etymological wordplays in Ennius’ tragedies, but also to appreciate the evolution of this stylistic figure in Rome.
Peindre l’Antiquité romaine à l’heure du pacifisme victorien : considérations sur un portrait d’Hadrien par Alma-Tadema
Authors: Le Pape Yannick
Published: April 2024

Roman antiquity was a major reference for artists all along the 19th century. In this time of European crisis, critics as public did appreciate how striking pictures (battles and sacrifices) depicted heroism and bravery. Although Sir Lawrence Alma-Tadema was the flagship of the British Classic Revival, he definitely chose to paint a different kind of serene Antiquity that was known to illustrate, at the very end, the current mood of English society. Hadrian in England Visiting a Romano-British Pottery, a 1884 painting, let us guess how Alma-Tadema used Antiquity that way, as Hadrian was the only emperor who came to England, not to mention that it was quite significant to figure the main actor of the pax Romana whereas European pacifist expectations were challenging British imperialism. Full of archeological details, this puzzling painting will help us to understand why ancient Rome became a prime model as well as an

ideological authority for Victorian England in search of legitimacy.
Plaute traducteur : poétique de la traduction ludique dans la comédie romaine
Authors: Daniel Clara
Published: April 2024

Considering contemporary literary standards, many studies of Roman comedy assume that Plautus is not a mere translator, or is more than a translator, because of his freedom in adapting Greek plays. However, rather than applying contemporary terminology to an ancient author, we reevaluate his relationship with the Greek source based upon his own theatrical poetics and the Roman conception of translation. We examine the transfer of Greek comedy to Roman games. By exploring the way Plautus presents his work in the prologues of his comedies and with examples from one play (Miles gloriosus), we aim at showing that the playwright plays with the process of linguistic and cultural translation which he exhibits to make his audience laugh. Between Greek source and Latin target, Plautinian uertere reveals a poetics of ludic translation.
Les remedia doloris chez Sénèque : exercices spirituels contre la douleur physique dans le stoïcisme et l’épicurisme
Authors: Courtil Jean-Christophe
Published: April 2024

Both Epicureanism and Stoicism proposed spiritual techniques for dealing with physical pain. For the Stoics, it is the practice of premeditation, which aims to imagine suffering in order to gradually become familiar with the idea of its necessity. This practice is part of a polemic with Epicurus, who categorically rejects it as useless, ineffective and even dangerous. However, this same criticism can be found in the work of the Stoic Seneca, who seems to speak as an Epicurean when he also states that it is useless to fear something that may not happen. In fact, Seneca distinguishes the useless and uncertain fear of future suffering from praemeditatio doloris which, properly conducted and subject to the moral judgement that identifies dolor as an indifferent, is a rational use of the imagination.
Study on serum uric acid concentration and serum uric acid/creatinine ratio in patients with type 2 diabetes
Authors: Vo Thai Duong , Nguyen Hoang Thanh Van
Published: April 2024

Objectives: 1. Determination of serum uric acid concentration and serum uric acid/creatinine ratio in patients with type 2 diabetes. 2. Find out correlations between serum uric acid, serum uric acid/creatinine ratio and some clinical and paraclinical characteristics in patients with type 2 diabetes.

Materials and methods: 141 patients with type 2 diabetes, at the Examination Department of Khanh Hoa Provincial General Hospital from April 2022 to June 2023; method: cross-sectional descriptive study, data processing using SPSS 18.0 software.

Results: men account for 56%, women account for 44%. The average age was 55.3 ± 9.7 year. The average time to detect diabetes is 9.4 ± 6.6 year. The rate of hypertension is 42.6%. The obesity rate is 26.2%. Average waist circumference: 81.06 ± 8.9 cm. Good fasting blood glucose control accounts for 39.0%, good HbA1c control accounts for 36.9%. The average GFR is: 83.42 ± 22.81 (ml/min/1.73m2), GFR reduction accounts for 11.3%, CKD accounts for 43.9%. The average serum UA concentration was: 345.87 ± 98.57 mmol/l, the average serum UA/Cre value was: 4.23 ± 1.3, with 23.4% increased serum UA. There is a negative correlation between UA and GFR, r = - 0.409. UA concentration in the group with CKD was higher than the group without CKD, p < 0.05. There is an association between UA according to CKD stage, p < 0.001. There is a relationship between UA/Cre according to CKD stage, p < 0.0001. There is a statistically significant relationship (p < 0.001) between UA concentration and urinary ACR level. Multivariable linear regression equation: GFR = 118.122 + 5.449*UA/Cre – 0.674*Age - 3.563*Urea - 0.014*ACR, with R2 = 64.1%, B = 5.449, p < 0.001. ROC curve analysis: Serum UA value: AUC = 0.767, p < 0.001, PI: 433.5, Se: 56.3%, Sp: 87.2%). Serum UA/Cre value: AUC = 0.131, p < 0.05.

Conclusions: Serum UA/Cre ratio has prognostic value for CKD in patients with type 2 diabetes (R2 = 64.1%, B = 5.449). Serum UA concentration is valuable in predicting the occurrence of CKD in patients with type 2 diabetes (AUC = 0.767, cut-off point is 434 (µmol/l), with Se: 56.3% and Sp: 87.2%.

Key words: diabetes, serum uric acid, serum uric acid/ creatinine ratio.
Root and canal morphology of mandibular second molar
Authors: Hoang Minh Phuong , Nguyen Thanh Nhan , Chau Ngoc Phuong Thanh , Van Thi Nhung , Vo Tran Nha Trang
Published: April 2024

Background: The mandibular second molar is the main chewing tooth and often suffer from pulp damage due to the misalignment of the mandibular third molar. In addition, it’s C-shaped root canal system is a challenge for endodontic treatment. This emphasizes the significance of tooth morphology and root canal system study which can contribute to anthropology, as well as Odonto-Stomatology. Purpose: The objective of this study was explore the morphology and root canal system of the mandibular second moalar in order to provide indicators dentistry applications.

Materials and methods: Preclinical (in vitro) study was conducted on 48 mandibular socond molars which was collected in Thua Thien Hue province from December 2021 to June 2022. The teeth were measured externally and determine the shape of the roots. The canal system was examined with two methods including clearing technique and Cone Beam CT.

Results: The average length of mandibular second molar was 20.37 ± 1.28 mm. 81.2% of teeth had one root, and 18.8% had two. The teeth with C-shaped roots accounted for 31.2%. The majority of distal roots possessed a simple type I (single canal) configuration. While the canal system of mesial roots was more complex which contained two canals, of which type I, II, III, IV were the most prevalent. C-shaped canal morphology was observed in 31.2% of the examined teeth.

Conclusion: The root canall system of mandibular second molar was complex, the percentage of C-shaped canal was high (31.2%). There was similarlu results of two methods of clearing technique and Cone Beam CT in examining the root canal system of mandibular second molars.

Key words: mandibular second molar, root canal system, C-shaped root, C-shaped root canal.
Research of beliefs about medicines by BMQ scale and related factors in hypertensive patients
Authors: Duong Thi Thuy Vy , Le Thi Thanh Tinh , Ngo Thi Kim Cuc , Tran Thi Thuy Nhi , Nguyen Thi Hai Yen , Nguyen Thi To , Le Chuyen
Published: April 2024

Introduction: Hypertension is a chronic disease that requires regular monitoring and treatment. Medication adherence and medication trust assessment play an important role in understanding the underlying causes and developing solutions to improve treatment outcomes for patients.

Objective: To assess medication trust in hypertensive patients and to explore the factors associated with medication trust according to the Beliefs about Medicines Questionnaire (BMQ) scale.

Methods: A cross-sectional study was conducted on 607 outpatients with hypertension who visited and received treatment at the University of Medicine and Pharmacy of Hue Hospital from July to November 2022.

Results: The mean age of patients was 69.7 ±11 years. The proportion of patients who agreed that taking medication is necessary was 99%. Only 3.1% of patients believed that doctors placed too much trust in medication, and about 5.1% believed that medication was harmful. About 62.8% of patients did not fully understand the medications they were taking.

Conclusions: We found that medication trust is closely associated with demographic characteristics, disease-related characteristics, knowledge about hypertension, the provision of health information and treatment medications.

Key words: beliefs about Medication, hypertension, BMQ scale
Formulating extended-release Meloxicam Pellets using the membrane coating technique
Authors: Nguyen Hong Trang , Ho Hoang Nhan , Nguyen Dang Thuy Anh , Ngo Thi Thu Thuy , Phan Thi Giang , Le Hoang Hao
Published: April 2024

Background: Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) with potent anti-inflammatory and analgesic effects but is associated with various side effects such as inducing gastrointestinal ulcers. Extended-release meloxicam pellets offer several advantages, including reducing the frequency of daily medication intake and providing sustained drug release over time, thereby minimizing gastrointestinal side effects. The study was conducted to formulate and develop the manufacturing process for meloxicam pellets, while simultaneously evaluating the physicochemical properties of the formulated pellets.

Materials and methods: Meloxicam, HPMC E5, and Ethyl Cellulose N7 were used in the study. Meloxicam pellets were formulated using the layering technique, initially depositing the drug onto inert pellets and subsequently extending the coating with Ethyl Cellulose N7.

Results: The pellet formula utilizes EC N7 with the role of providing extended-release kinetics following zero-order kinetics. The pellets exhibit uniform and attractive appearance, with dimensions ranging from 0.7 - 1 mm. The drug content is 2.38% ± 0.11% (w/w), demonstrating the ability to release the drug according to a zero-order kinetic model.

Conclusions: The study successfully formulated extended-release meloxicam pellets using a coating technique that involved a gradual deposition phase of the drug onto inert pellets, followed by an extended coating phase using a controlled-release excipient.

Key words: Meloxicam, pellet, coating technology.
A survey of post COVID-19 symptoms from the perspective of traditional medicine
Authors: Le Hoang Minh Quan , Do Thi Thuy Nhan , Le Gia Quoc Dat , Ngo Quang Vinh
Published: April 2024

Background: Individuals experiencing post-COVID-19 syndrome may endure lingering health deterioration, leading to challenges in daily activities and impacting mental and physical health, thus potentially burdening themselves, their families, and society. According to traditional medicine (TM), post-COVID-19 represents a recovery period following the flu in COVID. At this stage, the body remains incompletely restored, characterized by depleted vital energy and damaged body fluids, thus affecting the functions of various organ systems. To comprehensively understand post-COVID-19 symptoms from the perspective of traditional medicine and offer valuable insights for diagnosis, treatment, and prevention, this study conducted a survey of post-COVID-19 symptoms using the latent tree model.

Methods: A cross-sectional descriptive study was conducted. Data were collected through direct interviews with 282 post-COVID-19 patients over three months at the Ho Chi Minh City Traditional Medicine Hospital from January 2023 to May 2023.

Results: Among the collected samples, 38 post-COVID-19 symptoms were recorded, with the five most common symptoms being forgetfulness (58.2%), fatigue (47.5%), hair loss (42.6%), sleep disorders (25.9%), and shortness of breath (25.5%). Analysis using a latent tree model unveiled that within the kidney viscera, forgetfulness and hair loss emerged as primary symptoms, accompanied by tinnitus, anxiety, and hearing impairment. In the spleen viscera, fatigue prevailed as the main symptom, alongside muscle soreness, abdominal fullness, diarrhea, and constipation. In the lung viscera, shortness of breath was identified as the predominant symptom, accompanied by rapid breathing, coughing, breathing difficulties, and a sore throat. In the liver viscera, insomnia was the most perceived symptom, with secondary symptoms including anxiety, headache, and dizziness. In the heart viscera, primary symptoms included attention disorders and insomnia, with secondary symptoms being chest tightness.

Conclusion: The most common symptoms observed were forgetfulness, fatigue, hair loss, sleep disorders, and shortness of breath. Post-COVID-19 symptoms affect all five visceras according to traditional medicine.

Key words: Post COVID-19 symptoms; Traditional Medicine; Latent tree model.
Study the factors associated with mortality in sepsis adult patients at Hue Central Hospital 2021 - 2022
Authors: Nguyen Thi Phuong Thao , Nguyen Duy Binh , Pham Van Duc , Tran Xuan Chuong
Published: April 2024

Background: Sepsis has a high risk of death. Diagnosing and prognosing sepsis in the early stage play an important role, helping to reduce mortality and shorten the time of hospital stay of patients.

Aims: Study the factors associated with mortality in sepsis adult patients. Materials and method: 110 patients over 15 years old were diagnosed with sepsis, at the Department of Tropical Diseases and Intensive Care Unit, Hue Central Hospital from 1/2021 to 12/2022. Tracked cross-sectional descriptive study.

Results: The median age of sepsis patients was 66.4 ± 17.5. Male/female: 62/48. The duration of onset of the disease was about 4 days. The average length of hospital stay was 2 weeks. The rates of septic shock and multi-organ failure were 32.0% and 35.5%, respectively. The mortality rate was 20.0%. The heart, liver, respiratory, and kidney are the organs with the highest rates of dysfunction. There was a statistically significant difference in the time of hospital stay and the number of dysfunction organ, serum urea and creatinine between the two groups of death and survivors (p < 0.01). The SOFA score of patients who died gradually increased compared to the SOFA score at the admission, the survivors had a decrease in SOFA scores over time.

Conclusion: The majority of sepsis patients > 60 years old (66.4%), the proportion of males was higher than females. The rates of septic shock and multiple organ failure were 31.8% and 35.5%, respectively. The mortality rate was 20.0%. The heart, liver, respiratory, and kidney are the organs with the highest rates of organ failure. Factors that were independently associated with mortality in sepsis patients were time of hospital stay, serum creatinine, and SOFA_T24.

Key words: Sepsis, prognostic factor, mortality.
Antibiotic resistance’s of Staphylococcus aureus strains isolated at Hue University Hospital of Medicine and Pharmacy (3/2022 - 3/2023)
Authors: Nguyen Thi Chau Anh , Hoang Nhu Quynh , Nguyen Duc Hoang Sang , Nguyen Thi Tuyen , Hoang Thi Minh Ngoc , Duong Thi Ngoc Mai , Nguyen Thi Khanh Linh
Published: April 2024

Background: Staphylococcus aureus is one of the major causes of infections in hospitals. Many studies have pointed out the fact that Staphylococcus aureus is resistant to many antibiotics, especially Methicillin-Resistant Staphylococcus aureus (MRSA).

Objectives: To determine the frequency of Staphylococcus aureus and the frequency of the antibiotic resistance of S. aureus strains isolated at Hue University Hospital of Medicine and Pharmacy in 2022.

Materials and methods: A cross-sectional descriptive study on S. aureus strains isolated at Hue University Hospital of Medicine and Pharmacy from March 2022 to March 2023, determining antibiotic resistance by Kirby-Bauer technique.

Results: The frequency of S. aureus infections is 18.0%. The frequency of MRSA infections was 61.7%, the antibiotic resistance rates of S. aureus strains were the highest in the beta-lactam antibiotic group (61.7%-95.8%), followed by erythromycin 65.1%, clindamycin (59.9%). The rates of resistance of MRSA to penicillin, erythromycin, clindamycin, trimethoprim-sulfa antibiotics were higher than that of MSSA and this difference was statistically significant (p < 0.05). The rate of multi-resistance to over 6 antibiotics of MRSA accounted for 9.3%.

Conclusion: The frequency of S. aureus infections was 18.0%. The rate of MRSA accounts for 61.7%, the rate of multi-antibiotic resistant MRSA (over 6 antibiotics) was low, with 9.3%.

Key words: Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus, Atibiotic Resistance.
Evaluation of the effects of lyophilization and post-reconstitution stability of plasma samples containing PT, APTT, and Fibrinogen parameters
Authors: Le Van Chuong , Ngo Quoc Dat , Nguyen Kim Trung , Dang Le Bao Ngoc , Nguyen Tien Huynh , Nguyen Khanh Cuong , Nguyen Thi Thuy , Tran Nhat Nguyen
Published: April 2024

Objective: To evaluate the effects of lyophilization and post-reconstitution stability of plasma samples containing PT (Prothrombin Time), aPTT (activated Partial Thromboplastin Time), and fibrinogen parameters.

Research method: Experimental study was conducted on lyophilized plasma samples containing PT, aPTT, and fibrinogen parameters. The homogeneity of sample set before and after lyophilization was evaluated, then the stability of the sample set was assessed in variable time and temperature reservation conditions by Paired–samples t–test.

Results: Plasma samples containing 3 parameters PT, aPTT and fibrinogen were not significantly affected by the lyophilization process, shown through repeated measurements with p-value of 0.912, 0.699 and 0.334 respectively. Lyophilized plasma samples after reconstitution are stored at -20°C to achieve stability for 8 weeks, at 2 - 8°C stable for 24 hours, at laboratory temperature stable for 8 hours with all PT, aPTT, and fibrinogen parameters.

Conclusion: The freeze-drying process does not change the values of PT, aPTT, fibrinogen parameters in plasma samples, so it can be applied to produce coagulation proficiency testing samples by lyophilization. The reconstituted sample is stable in different time and reservation conditions, met the requierment of reservation condition of reconstituted sample.

Key words: Lyophilization, reconstitution, PT, aPTT, fibrinogen.
Evaluation of surgical outcomes in mechanical aortic valve replacement at Hue Central Hospital
Authors: Le Quang Thuu
Published: April 2024

Background: Mechanical aortic valve replacement (AVR) is the preferred treatment for young patients with severe aortic valve disease. Objective: To assess the outcomes of mechanical AVR.

Methods: This study included 41 patients who underwent mechanical AVR at the Department of Cardiovascular and Thoracic Surgery, Hue Central Hospital, from January 2021 to January 2023.

Results: The average age was 49.17 ± 10.78 years, with a male-to-female ratio of 4:3. Pre-surgery, 51.23% were in NYHA class I-II, and 48.77% in NYHA III-IV. Key measurements included a left ventricular ejection fraction (LVEF) of 56.17 ± 9.23%, a left ventricular end-diastolic diameter (LVEDD) of 52.66 ± 8.35 mm, and a left ventricular end-systolic diameter (LVESD) of 36.88 ± 8.02 mm. At 6 months, 87.81% were in NYHA I-II, and 12.19% in NYHA III-IV; LVEF was 61.68 ± 2.55%, LVEDD was 44.15 ± 4.08 mm, and LVESD was 29.0 ± 3.77 mm. Complications of acute kidney failure 7.31%, cardiac arrhythmia 4.88%. There were no deaths after surgery.

Conclusion: Mechanical AVR surgery is a safe and effective treatment option.

Key words: mechanical aortic valve replacement, aortic valve replacement, aortic valve.
İsmail Hikmetî’nin Farsça-Türkçe Manzum Sözlüğü: Tuhfe-i Nâdîde
Authors: Kaplan Yunus
Published: April 2024

Klasik Türk edebiyatının sahip olduğu renkli zenginliği yansıtan edebî türlerden biri olan ve genel itibarıyla Türkçe dışında farklı bir dilin öğretimini kolaylaştırmak için tanzim edilen manzum sözlük türünde birçok eser kaleme alınmıştır. Bunlardan biri de 18. yüzyıl mutasavvıf şairlerinden İsmail Hikmetî’nin (öl. 1773) Farsça-Türkçe şeklinde kaleme aldığı Tuhfe-i Nâdîde’dir. 1161/1748 yılında telif edilen eserin şimdilik bilinen tek yazma nüshası, Süleymaniye Kütüphanesi Hacı Mahmud Efendi Koleksiyonu 3638 numarada kayıtlıdır.
Müellifinin ifadesiyle Farsça-Türkçe manzum sözlüklerin en meşhuru olan Tuhfe-i Şâhidî’de bulunmayan bazı kelimeleri ihtiva eden Tuhfe-i Nâdîde, mensur bir mukaddime ve kelime anlamlarının verildiği beyit sayısı 13 ile 34 arasında değişkenlik gösteren beş kıtʻadan müteşekkildir. Beyit sayısı 99’u bulan kıt‘aların tanziminde herhangi bir tertip hususiyeti gözetilmemiş, kahir ekseri isim kökenli olan 280 civarında Farsça kelime ve ibarenin Türkçe karşılığına yer verilmiştir.
Bu çalışmada manzum sözlükler hakkında özet mahiyetinde bilgilendirmede bulunulduktan sonra, Tuhfe-i Nâdîde’nin sahip olduğu şekil ve muhteva özelliklerine temas edilmiş ve çeviri yazılı metnine yer verilmiştir.