bluuebunny/crossref_metadata_2025 huggingface dataset:
The Livestock Frontier in the Paraguayan Chaco: A Local Agent-based Perspective
Authors: Milán María José , González Elizabeth , López-i-Gelats Feliu
Published: March 2024

Deforestation is one of the most relevant transformations characterizing global environmental change in the tropics at present. There is wide consensus in pointing the context-dependent nature of tropical deforestation. In this sense, a better characterization of the phenomenon considering the social context could provide a more accurate picture of tropical deforestation. With this aim, a Q-methodology discourse analysis was conducted to characterise the different discourses that coexist in the particular region of the Paraguayan Chaco concerning the development of cattle ranching and derived deforestation. Four different discourses were identified as making sense the wide range of interests and values coexisting and clashing in the Paraguayan Chaco, namely: the Environmentalist discourse, the Business discourse, the Resigned discourse, and the Possibilist discourse. The results point that the fundamental differences between the discourses are largely explained by the different positions on three specific domains: (i) the socio-economic benefits the expansion of cattle ranching brings about; (ii) the environmental impacts the expansion of cattle ranching and the derived deforestation brings on; and, finally (iii) the degree to which an active intervention from the side of policy making to regulate the expansion of cattle ranching and to minimize possible detrimental effects is seen as necessary. The position of the different discourses in relation to these domains could help policy makers to make measures and regulations more widely accepted and followed.
Baricitinib for anti-melanoma differentiation-associated protein 5 antibody-positive dermatomyositis-associated interstitial lung disease: a case series and literature review on Janus kinase inhibitors for the disease
Authors: Harada Hiroaki , Shoda Hirofumi , Tsuchiya Haruka , Misaki Makoto , Sawada Takayuki , Fujio Keishi
Published: March 2024

Anti-melanoma differentiation-associated protein 5 antibody-positive dermatomyositis (anti-MDA5-DM) is frequently complicated by progressive interstitial lung disease (ILD), the prognosis of which is poor, and management is a major challenge. We treated three patients with anti-MDA5-DM-associated ILD (anti-MDA5-DM-ILD) using the Janus kinase (JAK) inhibitor, baricitinib, which improved lung opacities and saved two patients. We reviewed 6 patients with anti-MDA5-DM-ILD who had been treated with tofacitinib at our institution. Five of the patients survived, although discontinuation of tofacitinib due to complications was frequently observed. In addition, a literature search of patients with anti-MDA5-DM-ILD who were treated with JAK inhibitors yielded 21 articles involving 79 cases. All patients except one were treated with tofacitinib, and the survival rate was 75.9%. Although not statistically confirmed, the deceased patients tended to be older and had higher ferritin levels. A total of 92 complications were observed, 11 of which resulted in JAK inhibitor discontinuation. Cytomegalovirus reactivation comprised a substantial percentage of all complications and of those patients who required JAK inhibitor discontinuation. Five cases with fatal infective complications were also observed. While tofacitinib has been proposed to be a therapeutic option for anti-MDA5-DM-ILD, other JAK inhibitors, including baricitinib, are a treatment option. Further investigation is warranted to optimize treatment of anti-MDA5-DM-ILD.
Altered probe pressure and body position increase diagnostic accuracy for men and women in detecting hepatic steatosis using quantitative ultrasound
Authors: Byenfeldt Marie , Kihlberg Johan , Nasr Patrik , Grönlund Christer , Lindam Anna , Bartholomä Wolf C. , Lundberg Peter , Ekstedt Mattias
Published: March 2024

Objectives

To evaluate the diagnostic performance of ultrasound guided attenuation parameter (UGAP) for evaluating liver fat content with different probe forces and body positions, in relation to sex, and compared with proton density fat fraction (PDFF).

Methods

We prospectively enrolled a metabolic dysfunction-associated steatotic liver disease (MASLD) cohort that underwent UGAP and PDFF in the autumn of 2022. Mean UGAP values were obtained in supine and 30° left decubitus body position with normal 4 N and increased 30 N probe force. The diagnostic performance was evaluated by the area under the receiver operating characteristic curve (AUC).

Results

Among 60 individuals (mean age 52.9 years, SD 12.9; 30 men), we found the best diagnostic performance with increased probe force in 30° left decubitus position (AUC 0.90; 95% CI 0.82–0.98) with a cut-off of 0.58 dB/cm/MHz. For men, the best performance was in supine (AUC 0.91; 95% CI 0.81–1.00) with a cut-off of 0.60 dB/cm/MHz, and for women, 30° left decubitus position (AUC 0.93; 95% CI 0.83–1.00), with a cut-off 0.56 dB/cm/MHz, and increased 30 N probe force for both genders. No difference was in the mean UGAP value when altering body position. UGAP showed good to excellent intra-reproducibility (Intra-class correlation 0.872; 95% CI 0.794–0.921).

Conclusion

UGAP provides excellent diagnostic performance to detect liver fat content in metabolic dysfunction-associated steatotic liver diseases, with good to excellent intra-reproducibility. Regardless of sex, the highest diagnostic accuracy is achieved with increased probe force with men in supine and women in 30° left decubitus position, yielding different cut-offs.

Clinical relevance statement

The ultrasound method ultrasound-guided attenuation parameter shows excellent diagnostic accuracy and performs with good to excellent reproducibility. There is a possibility to alter body position and increase probe pressure, and different performances for men and women should be considered for the highest accuracy.

Key Points

• There is a possibility to alter body position when performing the ultrasound method ultrasound-guided attenuation parameter.

• Increase probe pressure for the highest accuracy.

• Different performances for men and women should be considered.

Graphical Abstract
Introduction, spread and selective breeding of crops: new archaeobotanical data from southern Italy in the early Middle Ages
Authors: Fiorentino Girolamo , Grasso Anna Maria , Primavera Milena
Published: March 2024

This paper presents a summary of the record of the cultivated plant macroremains from southern Italy during the early Middle Ages, with a focus on the recent discoveries of crop remains in Sicily. These have shed light on the introduction of new plants in the central Mediterranean region at ca. 500–1100ce. Specifically, we are dealing with the first evidence of the adoption of two new varieties of crops, one of flax (Linum usitatissimumcf. conv.mediterraneum) and the other of broad (or faba) bean (Vicia fabacf. var.equina) during the 8th century, a period of Byzantine domination, and also the introduction of exotic plants such asSolanum melongena(aubergine) andGossypium herbaceum/arboreum(cotton) following the Islamic conquest. In some cases these developments were to have long term impacts, for example in Sicily with regard to cotton, which became an important cash crop there in the 13th century, and throughout southern Italy with regard to a new variety ofVicia faba(Vicia fabacf. var.major), which was grown in Puglia from the late Middle Ages onwards.
Die Subanalyse von Rheuma-VOR zeigt den erheblichen Bedarf der rheumatologischen Versorgung auf
Authors: Hirsch Stefanie , Hoeper K. , Meyer-Olson D. , Schwarting A. , Gente K. , Dreher M. , Hoeper J. , Witte T. , Thiele T.
Published: March 2024

Hintergrund

Eine frühe Diagnose und Behandlung entzündlich-rheumatischer Erkrankungen kann Folgeschäden wie dauerhafte Einschränkungen der Mobilität und Gelenk- oder Organschäden verhindern. Gleichzeitig besteht ein größer werdendes Versorgungsdefizit aufgrund fehlender rheumatologischer Kapazitäten. Betroffen sind besonders die ländlichen Regionen.

Ziel der Arbeit

Die vorliegenden nicht bestätigten Diagnosen der Studie Rheuma-VOR wurden hinsichtlich des Vorliegens einer anderen definitiven entzündlich-rheumatischen Erkrankung analysiert.

Material und Methoden

Die eingegangenen Fragebögen der an der Rheuma-VOR-Studie teilnehmenden Rheumatolog:innen wurden nach Vermerken anderer entzündlich-rheumatischer Erkrankungen als der geforderten Diagnose einer rheumatoiden Arthritis, Psoriasis-Arthritis oder Spondyloarthritis gescreent.

Ergebnisse

Von 910 „nicht bestätigten“ Diagnosen waren bei 245 Patient:innen andere gestellte Diagnosen auszuwerten. Insgesamt 29,8 % der Diagnosen entsprechen degenerativen Gelenkveränderungen oder chronischen Schmerzsyndromen, bei 26,1 % lagen verschiedene Formen entzündlicher Arthritiden vor. Der Großteil der Diagnosen (40,5 %) entfiel auf Kollagenosen und Vaskulitiden, wobei die Polymyalgia rheumatica mit 20 % am häufigsten diagnostiziert wurde (49 Patient:innen).

Diskussion

Die vorliegenden Daten zeigen, dass bei einem Großteil der Patient:innen die rheumatologische Vorstellung indiziert war. Aufgrund der ambulanten Versorgungsdefizite ist eine vorherige Selektion des Patientenguts essenziell, um die eingeschränkten Kapazitäten bestmöglich zu nutzen.
Investigation of lacrimal gland and extraocular muscle in thyroid eye disease patients with severe subjective dry eye disease: a multiparametric magnetic resonance imaging study
Authors: Liao Xulin , Aljufairi Fatema Mohamed Ali Abdulla , Sebastian Jake Uy , Jia Ruofan , Wong Hanson Yiu Man , Lai Kenneth Ka Hei , Chen Wanxue , Hu Zhichao , Wei Yingying , Chu Winnie Chiu Wing , Tham Clement Chee Yung , Pang Chi Pui , Chong Kelvin Kam Lung
Published: March 2024

Purpose

To analyze the radiological features of the lacrimal gland (LG) and extraocular muscle (EOM) in thyroid eye disease (TED) patients with severe subjective dry eye disease (DED) using magnetic resonance imaging (MRI) measurements.

Methods

In this cross-sectional study, mechanical ocular exposure, dry eye assessment and MRI data were collected. Patients were classified into non-severe subjective DED group with ocular surface disease index (OSDI) < 33 and severe subjective DED group with OSDI ≥ 33. Linear regression model was applied for comparing the OSDI < 33 and OSDI ≥ 33 group in TED patients. The predictive performance of MRI parameters and models was assessed by receiver operating characteristic curve (ROC) analysis.

Results

Consecutive 88 TED patients (176 eyes) were included in this study. In the OSDI < 33 group, 52 TED patients (104 eyes) with a mean clinical activity score (CAS) of 0.63 ± 0.75. In the OSDI ≥ 33 group, there are 36 TED patients (72 eyes), with a mean CAS of 1.50 ± 1.54. The age and sex of the patients were matched between the two groups. The OSDI ≥ 33 group had shorter tear break-up time, larger levator palpebrae superioris / superior rectus (LPS/SR), inferior rectus and lateral rectus, smaller LG, more inflammatory LPS/SR and inferior rectus than OSDI < 33 DED group (P < 0.05). In the linear regression analysis, compare to the OSDI < 33 DED group, the OSDI ≥ 33 group had larger medial rectus cross-sectional area (β = 0.06, 95%CI: (0.02, 0.10), P = 0.008), larger inferior rectus cross-sectional area (β = 0.06, 95%CI: (0.00, 0.12), P = 0.048), smaller LG cross-sectional area (β = -0.14, 95%CI: (-0.25, -0.04), P = 0.008). In the ROC analysis, the area under curve of medial rectus, inferior rectus, LG, and combined model are 0.625, 0.640, 0.661 and 0.716, respectively.

Conclusion

Multiparametric MRI parameters of the LG and EOM in TED patients with severe subjective DED were significantly altered. Novel models combining the cross-sectional area of LG, medial rectus and inferior rectus showed good predictive performance in TED patients with severe subjective DED.
Glucose ingestion before and after resistance training sessions does not augment ribosome biogenesis in healthy moderately trained young adults
Authors: Lian Kristian , Hammarström Daniel , Hamarsland Håvard , Mølmen Knut Sindre , Moen Sara Christine , Ellefsen Stian
Published: March 2024

Purpose

Resistance training-induced skeletal muscle hypertrophy seems to depend on ribosome biogenesis and content. High glucose treatment may augment ribosome biogenesis through potentiating resistance training-induced adaptations. This was investigated with total RNA and ribosomal RNA abundances as main outcomes, with relevant transcriptional/translational regulators (c-Myc/UBF/rpS6) as a secondary outcome.

Methods

Sixteen healthy, moderately trained individuals [male/female, n = 9/7; age, 24.1 (3.3)] participated in a within-participant crossover trial with unilateral resistance training (leg press and knee extension, 3 sets of 10 repetitions maximum) and pre- and post-exercise ingestion of either glucose (3 × 30 g, 90 g total) or placebo supplements (Stevia rebaudiana, 3 × 0.3 g, 0.9 g total), together with protein (2 × 25 g, 50 g total), on alternating days for 12 days. Six morning resistance exercise sessions were conducted per condition, and the sessions were performed in an otherwise fasted state. Micro-biopsies were sampled from m. vastus lateralis before and after the intervention.

Results

Glucose ingestion did not have beneficial effects on resistance training-induced increases of ribosomal content (mean difference 7.6% [− 7.2, 24.9], p = 0.34; ribosomal RNA, 47S/18S/28S/5.8S/5S, range 7.6–37.9%, p = 0.40–0.98) or levels of relevant transcriptional or translational regulators (c-MYK/UBF/rpS6, p = 0.094–0.292). Of note, both baseline and trained state data of total RNA showed a linear relationship with UBF; a ∼14% increase in total RNA corresponded to 1 SD unit increase in UBF (p = 0.003).

Conclusion

Glucose ingestion before and after resistance training sessions did not augment ribosomal RNA accumulation during twelve days of heavy-load resistance training in moderately trained young adults.
The emergence of the Medical University of Vienna 20 years ago
Authors: Schütz Wolfgang , Grimm Markus
Published: March 2024

At the beginning of the 2000s the Austrian public universities were characterized by staffing rigidities, little competitive research, outdated study curricula and free access to all fields of study, the latter combined with high dropout rates and long study durations. As a countermeasure the universities were granted full legal capacity. For new employees the status of civil servants was herewith cancelled and, being now subject to the Employment Act, tenured employments for anyone who wanted to stay at the university were no longer possible. Medical faculties always had special provisions which would be difficult to reconcile with the full legal capacity of the universities: (i) the requirements of the hospitals affiliated to universities for research and teaching in addition to patient care had to be reimbursed to the Austrian federal states maintaining the hospitals, (ii) the physicians of university-affiliated hospitals were largely employed by the respective university and (iii) to ensure financing of clinical research and teaching at the hospital, the medical faculties received a budget separated from the rest of the university. As it was neither politically possible nor foreseeable that universities would be able to form a subcorporation with the affiliated hospital (integration model) or at least a close cooperation with the hospital if that has legal capacity per se (cooperation model), the necessary budgetary sovereignty of the medical faculties could only be guaranteed by their transition to medical universities. Nonetheless, reservations about this spin-off of medicine were enormous, but quickly fell silent, as the newly established medical universities maintained close cooperations with their parent as well as other universities and achieved, for Austrian standards, favorable positions in international rankings.
Are there gender-specific differences in hip and knee cartilage composition and degeneration? A systematic literature review
Authors: Di Martino Alberto , Barile Francesca , D’Agostino Claudio , Castafaro Vanita , Cerasoli Tosca , Mora Paolo , Ruffilli Alberto , Traina Francesco , Faldini Cesare
Published: March 2024

The aim of the present review is to systematically analyse the current literature about gender differences in hip or knee cartilage composition and degeneration, to help explaining how and why osteoarthritis affects women more often and more severely than men. A systematic review of the literature in English was performed. Eleven studies on 1962 patients (905 females and 787 males) that reported differences on cartilage composition between males and females were included. Nine evaluated the knee, one the hip, and one both. They were heterogeneous in their methods: one conducted histological analyses, and all the others evaluated cartilage characteristics (volume, width, and composition) through magnetic resonance imaging. All authors reported gender differences in both volume and morphology of the cartilage, from infancy to menopause. In fact, a study on 92 healthy children statistically showed significant gender differences in cartilage thickness at all sites, even after adjustment for age, body, and bone size. Gender differences become more evident after menopause, when women have a lower cartilage volume and a higher cartilage loss. Men show significantly higher knee and hip cartilage volumes than women, and women carry a significantly greater risk to develop osteoarthritis. This is in part due to body and bone size, but also depends on qualitative and quantitative differences in the composition of cartilage and its degeneration rate after menopause. Structural changes in cartilage that occur between genders during ageing have significance in the development of osteoarthritis.
The legal incidence of ad valorem taxes matters
Authors: Pauwels Wilfried , Schroyen Fred
Published: March 2024

It is well known that, for a specific tax, its economic incidence does not depend on which side of the market has the legal obligation to pay the tax. In this paper, we show that, for an ad valorem tax, this legal incidence does matter for the economic incidence. In particular, when a government imposes an ad valorem tax rate on the sale of a commodity, the resulting reduction in the market equilibrium level of sales will be larger when sellers are obliged to pay the tax than when buyers are obliged to pay the tax.
Assessment of music performance anxiety in a virtual auditorium through the study of ambient lighting and audience distance
Authors: Gómez-Sirvent José L. , Fernández-Sotos Alicia , Fernández-Caballero Antonio , Fernández-Sotos Desirée
Published: March 2024

Performance anxiety is a common problem affecting musicians’ concentration and well-being. Musicians frequently encounter greater challenges and emotional discomfort when performing in front of an audience. Recent research suggests an important relationship between the characteristics of the built environment and people’s well-being. In this study, we explore modifying the built environment to create spaces where musicians are less aware of the presence of the audience and can express themselves more comfortably. An experiment was conducted with 61 conservatory musicians playing their instrument in a virtual auditorium in front of an audience of hundreds of virtual humans. They performed at different distances from the audience and under different levels of ambient lighting, while their eye movements were recorded. These data, together with questionnaires, were used to analyse the way the environment is perceived. The results showed that reducing the light intensity above the audience made the view of the auditorium more calming, and the same effect was observed when the distance between the audience and the musician was increased. Eye-tracking data showed a significant reduction in saccadic eye movements as the distance from the audience increased. This work provides a novel approach to architecture influence on musicians’ experience during solo performances. The findings are useful to designers and researchers.
Enhancing weight perception in virtual reality: an analysis of kinematic features
Authors: Moosavi Mahdiyeh Sadat , Raimbaud Pierre , Guillet Christophe , Mérienne Frédéric
Published: March 2024

This study investigates weight perception in virtual reality without kinesthetic feedback from the real world, by means of an illusory method called pseudo-haptic. This illusory model focuses on the dissociation of visual input and somatosensory feedback and tries to induce the sensation of virtual objects' loads in VR users by manipulating visual input. For that, modifications on the control-display ratio, i.e., between the real and virtual motions of the arm, can be used to produce a visual illusionary effect on the virtual objects' positions as well. Therefore, VR users perceive it as velocity variations in the objects' displacements, helping them achieve a better sensation of virtual weight. A primary contribution of this paper is the development of a novel, holistic assessment methodology that measures the sense of the presence in virtual reality contexts, particularly when participants are lifting virtual objects and experiencing their weight. Our study examined the effect of virtual object weight on the kinematic parameters and velocity profiles of participants' upward arm motions, along with a parallel experiment conducted using real weights. By comparing the lifting of real objects with that of virtual objects, it was possible to gain insight into the variations in kinematic features observed in participants' arm motions. Additionally, subjective measurements, utilizing the Borg CR10 questionnaire, were conducted to assess participants' perceptions of hand fatigue. The analysis of collected data, encompassing both subjective and objective measurements, concluded that participants experienced similar sensations of fatigue and changes in hand kinematics during both virtual object tasks, resulting from pseudo-haptic feedback, and real weight lifting tasks. This consistency in findings underscores the efficacy of pseudo-haptic feedback in simulating realistic weight sensations in virtual environments.
Exploring the Use of Interleaved Stimuli to Measure Cochlear-Implant Excitation Patterns
Authors: Guérit François , Middlebrooks John C. , Gransier Robin , Richardson Matthew L. , Wouters Jan , Carlyon Robert P.
Published: March 2024

Purpose

Attempts to use current-focussing strategies with cochlear implants (CI) to reduce neural spread-of-excitation have met with only mixed success in human studies, in contrast to promising results in animal studies. Although this discrepancy could stem from between-species anatomical and aetiological differences, the masking experiments used in human studies may be insufficiently sensitive to differences in excitation-pattern width.

Methods

We used an interleaved-masking method to measure psychophysical excitation patterns in seven participants with four masker stimulation configurations: monopolar (MP), partial tripolar (pTP), a wider partial tripolar (pTP + 2), and, importantly, a condition (RP + 2) designed to produce a broader excitation pattern than MP. The probe was always in partial-tripolar configuration.

Results

We found a significant effect of stimulation configuration on both the amount of on-site masking (mask and probe on same electrode; an indirect indicator of sharpness) and the difference between off-site and on-site masking. Differences were driven solely by RP + 2 producing a broader excitation pattern than the other configurations, whereas monopolar and the two current-focussing configurations did not statistically differ from each other.

Conclusion

A method that is sensitive enough to reveal a modest broadening in RP + 2 showed no evidence for sharpening with focussed stimulation. We also showed that although voltage recordings from the implant accurately predicted a broadening of the psychophysical excitation patterns with RP + 2, they wrongly predicted a strong sharpening with pTP + 2. We additionally argue, based on our recent research, that the interleaved-masking method can usefully be applied to non-human species and objective measures of CI excitation patterns.
A Fibrin-Thrombin Based In Vitro Perfusion System to Study Flow-Related Prosthetic Heart Valves Thrombosis
Authors: Kreinin Yevgeniy , Talmon Yahel , Levi Moran , Khoury Maria , Or Itay , Raad Mahli , Bolotin Gil , Sznitman Josué , Korin Netanel
Published: March 2024

Prosthetic heart valve (PHV) replacement has increased the survival rate and quality of life for heart valve-diseased patients. However, PHV thrombosis remains a critical problem associated with these procedures. To better understand the PHV flow-related thrombosis problem, appropriate experimental models need to be developed. In this study, we present an in vitro fibrin clot model that mimics clot accumulation in PHVs under relevant hydrodynamic conditions while allowing real-time imaging. We created 3D-printed mechanical aortic valve models that were inserted into a transparent glass aorta model and connected to a system that simulates human aortic flow pulse and pressures. Thrombin was gradually injected into a circulating fibrinogen solution to induce fibrin clot formation, and clot accumulation was quantified via image analysis. The results of valves positioned in a normal versus a tilted configuration showed that clot accumulation correlated with the local flow features and was mainly present in areas of low shear and high residence time, where recirculating flows are dominant, as supported by computational fluid dynamic simulations. Overall, our work suggests that the developed method may provide data on flow-related clot accumulation in PHVs and may contribute to exploring new approaches and valve designs to reduce valve thrombosis.
Generalizing actions with the subtraction-compensation property: primary students’ algebraic thinking with tasks involving vertical towers of blocks
Authors: Wilkie Karina J. , Hopkins Sarah
Published: March 2024

An important approach for developing children’s algebraic thinking involves introducing them to generalized arithmetic at the time they are learning arithmetic. Our aim in this study was to investigate children’s attention to and expression of generality with the subtraction-compensation property, as evidence of a type of algebraic thinking known as relational thinking. The tasks involved subtraction modelled as difference and comparing the heights of towers of blocks. In an exploratory qualitative study, 22 middle primary (9–11-year-old) students from two schools participated in individual videoed interviews. The tasks were designed using theoretical perspectives on embodied visualization and concreteness fading to provide multiple opportunities for the students to make sense of subtraction as difference and to advance their relational thinking. Twelve out of 22 students evidenced conceptual understanding of the comparison model of subtraction (subtraction as difference) and expression of the compensation property of equality. Four of these students repeatedly evidenced relational thinking for true/false tasks and open equivalence tasks. A proposed framework for levels of attention to/expression of generality with the subtraction-compensation property is shared and suggestions for further research are presented.
Reverse-Engineering Risk
Authors: O’Sullivan Angela , Mace Lilith
Published: March 2024

Three philosophical accounts of risk dominate the contemporary literature. On the probabilistic account, risk has to do with the probability of a disvaluable event obtaining; on the modal account, it has to do with the modal closeness of that event obtaining; on the normic account, it has to do with the normalcy of that event obtaining. The debate between these accounts has proceeded via counterexample-trading, with each account having some cases it explains better than others, and some cases that it cannot explain at all. In this article, we attempt to break the impasse between the three accounts of risk through a shift in methodology. We investigate the concept of risk via the method of conceptual reverse-engineering, whereby a theorist reconstructs the need that a concept serves for a group of agents in order to illuminate the shape of the concept: its intension and extension. We suggest that risk functions to meet our need to make decisions that reduce disvalue under conditions of uncertainty. Our project makes plausible that risk is a pluralist concept: meeting this need requires that risk takes different forms in different contexts. But our pluralism is principled: each of these different forms are part of one and the same concept, that has a ‘core-to-periphery’ structure, where the form the concept takes in typical cases (at its ‘core’) explains the form it takes in less typical cases (at its ‘periphery’). We then apply our findings to epistemic risk, to resolve an ambiguity in how ‘epistemic risk’ is standardly understood.
Reflective Awareness, Phenomenal Conservatism, and Phenomenal Explanationism
Authors: McCain Kevin , Moretti Luca
Published: March 2024

According to Phenomenal Conservatism (PC), if a subject S has an appearance that P, in the absence of defeaters, S has justification for believing P by virtue of her appearance’s inherent justifying power. McCain and Moretti (2021) have argued that PC is affected by the problem of reflective awareness: if a subject S becomes reflectively aware of an appearance, the appearance loses its inherent justifying power. This limits the explanatory power of PC and reduces its anti-sceptical bite. This article provides a novel argument to the same conclusion and contends that it does not apply to Phenomenal Explanationism, the appearance-based account of justification alternative to PC defended by McCain and Moretti (2021).
No Trespassing! Abandoning the Novice/Expert Problem
Authors: Levy Neil
Published: March 2024

The novice/expert problem is the problem of knowing which apparent expert to trust. Following Alvin Goldman’s lead, a number of philosophers have developed criteria that novices can use to distinguish more from less trustworthy experts. While the criteria the philosophers have identified are indeed useful in guiding expert choice, I argue, they can’t do the work that Goldman and his successors want from them: avoid a kind of testimonial scepticism. We can’t deploy them in the way needed to avoid such scepticism, because it would take genuine expertise to do so. I argue that attempts to deploy them in this sort of deep way involve a kind of transgression akin to, and at least as unreliable as, epistemic trespassing. We should give up trying to solve the novice/expert problem and instead promote better epistemic trust.
The Right to Climate Adaptation
Authors: Byskov Morten Fibieger
Published: March 2024

The Intergovernmental Panel for Climate Change has over the past decade repeatedly warned that we are heading towards inevitable and irreversible climate change, which will negatively affect the lives, livelihoods, and well-being of millions of people around the world, both at present and in the future. In fact, many people, especially vulnerable and marginalized communities in low- and middle-income countries, already live with the effects of climate change in their daily lives. While adaptation – along with mitigation and compensation for loss and damage as a consequence of climate change – was identified as the central pillars of a just climate policy in the Paris Agreement it is unclear whether this entails a right to adaptation – that some people are owed, as a matter of justice, to have the ability to adapt to climate change – and, if so, what such a right would look like. In this paper, I argue that individuals and communities who are or will be negatively affected by climate change through no fault of their own should have the right to adaptation. I argue that the right to adaptation should be specified through four questions: (i) who has a right to adaptation; (ii) what is it a right to; (iii) how much is it a right to; and (iv) who has the duty to uphold the right to adaptation?
Long-term analysis of a psychoeducational course on university students’ mental well-being
Authors: Hobbs Catherine , Jelbert Sarah , Santos Laurie R. , Hood Bruce
Published: March 2024

Although many higher educational institute (HEI) psychoeducational courses teaching positive psychology interventions report benefits to mental well-being upon completion, they have not typically addressed whether such beneficial effects are sustained long-term beyond the period of the courses. Here, we report a pre-registered follow-up of 228 undergraduate students, from a variety of disciplines, who took a positive psychology course 1 or 2 years previously. Overall, group analysis revealed that students who had taken the course did not continue to show the originally reported benefits at follow-up. Students who had taken the course scored higher on mental well-being than other students tested using a university-wide survey, but they were also higher at baseline 1–2 years earlier indicating a sampling bias. An exploratory analysis, however, revealed that 115 students (51% of the group) who had continued to practice the recommended activities taught during the course maintained their increased mental well-being over the period of follow-up. We therefore suggest that continued engagement is a key factor in sustaining the long-term benefits of positive psychology courses. Implementation of such courses should therefore include provision and mechanisms for maintaining future student engagement.
Factors driving the bioavailability of particulate organic matter in the Ross Sea (Antarctica) during summer
Authors: Misic Cristina , Bolinesi Francesco , Castellano Michela , Olivari Enrico , Povero Paolo , Fusco Giannetta , Saggiomo Maria , Mangoni Olga
Published: March 2024

The biochemical composition and bioavailability of particulate organic matter (POM) were studied in relation to abiotic (water column stratification, macronutrient concentrations) and biotic factors (phytoplankton biomass and functional groups) in the open Ross Sea and coastal area of Terra Nova Bay, Antarctica, during the austral summer 2017. The presence of different sub-systems was highlighted by spatial and temporal variations of all the considered variables, characterised by higher concentrations of particulate organic carbon and nitrogen in Terra Nova Bay, where diatoms dominated, while in the open Ross Sea was higher the contribution of haptophytes (Phaeocystis antarctica Karsten, 1905). The southernmost Ross Sea was characterised by significantly higher concentrations of carbohydrates in the entire water column. High lipid contribution and low photosynthetic activity indicated aged POM, suggesting that POM was composed mainly by the remnants of previous haptophytes production. The higher lability of the carbohydrates indicated that an increase of haptophytes in the area could alter the biogeochemical C cycle, reducing the storage of refractory carbon in the depths, and favouring the transfer and respiration of C in the trophic web, with a decrease of export rate in the Ross Sea.
Visible-light optical limiting of vanadia–polyvinylpyrrolidone nanofibers
Authors: Pepe Yasemin , Tutel Yusuf , Akkoyun Serife , Asci Nurcan , Cevik Eda , Karatay Ahmet , Unalan Husnu Emrah , Elmali Ayhan
Published: March 2024

In this work, vanadium pentoxide (V2O5) nanoparticles-filled electrospun polyvinylpyrrolidone (PVP) nanofibers were investigated systematically at various nanofiller weight percentages (8 and 10 wt%) and input intensities to reveal the effective optical limiting feature in the visible spectrum. XRD analysis demonstrated the purity of the produced V2O5 nanoparticles. According to SEM findings, V2O5 nanoparticles were effectively integrated into the PVP nanofibers. Two distinct absorption bands were observed at around 400 and 217 nm. These bands were related to PVP and V2O5 nanoparticles in linear absorption measurements, respectively. Moreover, an increased Urbach energy value was obtained with an increase in V2O5 nanofiller content within PVP. Open-aperture Z-scan measurements were taken at 532 nm considering the band gap energy of the V2O5 nanofillers in PVP composite nanofibers. In 8 wt% V2O5 nanofilled PVP nanofibers, one-photon absorption (OPA) was the main nonlinear absorption (NA) mechanism, and the defect states of the V2O5 nanoparticles had no contribution to NA. On the other hand, sequential two-photon absorption was the main NA mechanism, and the defect states of the nanoparticles caused more efficient NA behavior in 10 wt% V2O5 nanofilled PVP nanofibers. The effective optical limiting behavior was obtained for this composite nanofiber with lower limiting threshold as 1.49 × 10–5 J/cm2. The V2O5 nanofilled PVP nanofibers presented strong potential optical limiters in the visible wavelength region. This was attributed to their high linear transmittance at low input intensities and their robust NA behavior at higher input intensities.
Rough Differential Equations Containing Path-Dependent Bounded Variation Terms
Authors: Aida Shigeki
Published: March 2024

We consider rough differential equations whose coefficients contain path-dependent bounded variation terms and prove the existence and a priori estimate of solutions. These equations include classical path-dependent stochastic differential equations containing running maximum processes and normal reflection terms. We apply these results to determine the topological support of the solution processes.
Exosomes derived from human umbilical cord mesenchymal stem cells decrease neuroinflammation and facilitate the restoration of nerve function in rats suffering from intracerebral hemorrhage
Authors: Nan Chengrui , Zhang Yan , Zhang Aobo , Shi Yunpeng , Yan Dongdong , Sun Zhimin , Jin Qianxu , Huo Haoran , Zhuo Yayu , Zhao Zongmao
Published: March 2024

Exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSC-ex) have become a hopeful substitute for whole-cell therapy due to their minimal immunogenicity and tumorigenicity. The present study aimed to investigate the hypothesis that hUCMSC-ex can alleviate excessive inflammation resulting from intracerebral hemorrhage (ICH) and facilitate the rehabilitation of the nervous system in rats. In vivo, hemorrhagic stroke was induced by injecting collagenase IV into the striatum of rats using stereotactic techniques. hUCMSC-ex were injected via the tail vein at 6 h after ICH model establishment at a dosage of 200 µg. In vitro, astrocytes were pretreated with hUCMSC-ex and then stimulated with hemin (20 μmol/mL) to establish an ICH cell model. The expression of TLR4/NF-κB signaling pathway proteins and inflammatory factors, including TNF-α, IL-1β, and IL-10, was assessed both in vivo and in vitro to investigate the impact of hUCMSC-ex on inflammation. The neurological function of the ICH rats was evaluated using the corner turn test, forelimb placement test, Longa score, and Bederson score on the 1st, 3rd, and 5th day. Additionally, RT-PCR was employed to examine the mRNA expression of TLR4 following hUCMSC-ex treatment. The findings demonstrated that hUCMSC-ex downregulated the protein expression of TLR4, NF-κB/P65, and p-P65, reduced the levels of pro-inflammatory cytokines TNF-α and IL-1β, and increased the expression of the anti-inflammatory cytokine IL-10. Ultimately, the administration of hUCMSC-ex improved the behavioral performance of the ICH rats. However, the results of PT-PCR indicated that hUCMSC-ex did not affect the expression of TLR4 mRNA induced by ICH, suggesting that hUCMSCs-ex may inhibit TLR4 translation rather than transcription, thereby suppressing the TLR4/NF-κB signaling pathway. We can conclude that hUCMSC-ex mitigates hyperinflammation following ICH by inhibiting the TLR4/NF-κB signaling pathway. This study provides preclinical evidence for the potential future application of hUCMSC-ex in the treatment of cerebral injury.
Accurate detection of coronavirus cases using deep learning with attention mechanism and genetic algorithm
Authors: Kara Ahmet
Published: March 2024

The novel coronavirus disease has caused severe threats to the daily life and health of people all over the world. Hence, early detection and timely treatment of this disease are significant to prevent the coronavirus's spread and ensure more effective patient care. This work adopted an integrated framework comprising deep learning and attention mechanism to provide a more effective and reliable diagnosis. This framework consists of two convolution neural network (CNN), a bidirectional LSTM, two fully-connected layers (FCL), and an attention mechanism. The main aim of the proposed framework is to reveal a promising approach based on deep learning for early and timely detection of coronavirus disease. For greater accuracy, the framework's hyperparameters are tuned by means of a genetic algorithm. The effectiveness of the proposed framework has been examined utilizing a public dataset including 18 different blood findings from Albert Einstein Israelita Hospital in Sao Paulo, Brazil. Additionally, within the experimental studies, the proposed framework is subjected to comparison with the state-of-the-art techniques, evaluated across various metrics. Based on the derived consequences, the proposed framework has yielded enhancements in accuracy, recall, precision, and F1-score, registering approximate improvements of 1.27%, 4.07%, 3.20%, and 2.88%, respectively, as measured against the second-best rates.
Exploring the potential of topsoil pellets to improve native seedling establishment on degraded agricultural land
Authors: Munro Thomas P. , Erickson Todd E. , Nimmo Dale G. , Dadzie Frederick A. , Muñoz-Rojas Miriam , Price Jodi N.
Published: March 2024

Background and aims

Agricultural activities can degrade soils and promote weeds, posing challenges to native species restoration. In agricultural restoration, removing contaminated topsoil is a method designed to reduce elevated soil nutrients caused by fertilisation. This strategy targets weed control by eliminating both aboveground weeds and their soil seed bank before direct seeding. However, it also diminishes native soil seed banks and beneficial soil microbes. We investigated the potential of fresh topsoil pellets containing seeds to improve seedling performance in a degraded grassy woodland where topsoil had been removed.

Methods

We tested various pellet recipes, including one using commercial ingredients and three with different topsoil proportions (30%, 50%, and 70%). The study was conducted in a degraded grassy woodland in southeastern Australia, where topsoil was removed for restoration. We explored the effect of these pellet varieties on seedling emergence and growth of six native species common in this community, as well as microbial activity in the soil surrounding the seedlings.

Results

Pellets significantly improved the emergence of Chrysocephalum apiculatum, providing evidence of their effectiveness. However, pellets significantly reduced Arthropodium milleflorum and Glycine tabacina emergence. Linum marginale and Rytidosperma caespitosum emergence remained unaffected by pellets. One species, Bothriochloa macra, had insufficient emergence for analysis. The microbial activity of the soil surrounding Rytidosperma caespitosum seedlings was significantly improved by pellets, with no significant effects observed for other species.

Conclusion

Our results demonstrate that topsoil pellets improved the emergence of one native species, but reduced emergence for two others, indicating species-specific responses to pelleting.
Bolzano’s Tortoise and a loophole for Achilles
Authors: Kappes Yannic
Published: March 2024

This paper discusses a novel response to two closely related regress arguments from Bolzano’s Theory of Science and Carroll’s What the Tortoise Said to Achilles. Bolzano’s argument aims to refute the thesis that full grounds must include propositions involving notions such as entailment, grounding or lawhood which link the respective grounds to their groundee. This thesis is motivated, Bolzano’s argument is reconstructed, and a response based on self-referential linking propositions is developed and defended against objections concerning self-reference and Curry’s paradox. Finally, the idea is applied to a reading of Carroll’s dialogue and a corresponding solution to the so-called infinite regress problem of inference is proposed.
Roughness Evolution Induced by Third-Body Wear
Authors: Garcia-Suarez Joaquin , Brink Tobias , Molinari Jean-François
Published: March 2024

Surface roughness is a key factor when it comes to friction and wear, as well as to other physical properties. These phenomena are controlled by mechanisms acting at small scales, in which the topography of apparently flat surfaces is revealed. Roughness in natural surfaces has been reported to conform to self-affine statistics in a wide variety of settings (ranging from earthquake physics to micro-electro-mechanical devices), meaning that the height profile can be described using a spectrum where the amplitude is proportional to its wavelength raised to a constant power, which is related to a statistical parameter named Hurst exponent. We analyze the roughness evolution in atomistic surfaces during molecular dynamics simulations of wear. Both pairs of initially flat and initially rough surfaces in contact are worn by a third body formed by particles trapped between them during relative sliding. During the first sliding stages, the particles trapped between the first bodies scratch the surfaces. Once the former becomes coated with atoms from the latter, the wear process slows down and becomes “adhesive like.” The initial particle sizes are consistent with the minimum size to be expected for the debris, but tend to grow by material removal from the surfaces and to agglomerate. We show that, for the particular configurations under consideration, the surface roughness seems to converge to a steady state characterized by Hurst exponent close to 0.8, independently of the initial conditions.
Unsupervised Point Cloud Representation Learning by Clustering and Neural Rendering
Authors: Mei Guofeng , Saltori Cristiano , Ricci Elisa , Sebe Nicu , Wu Qiang , Zhang Jian , Poiesi Fabio
Published: March 2024

Data augmentation has contributed to the rapid advancement of unsupervised learning on 3D point clouds. However, we argue that data augmentation is not ideal, as it requires a careful application-dependent selection of the types of augmentations to be performed, thus potentially biasing the information learned by the network during self-training. Moreover, several unsupervised methods only focus on uni-modal information, thus potentially introducing challenges in the case of sparse and textureless point clouds. To address these issues, we propose an augmentation-free unsupervised approach for point clouds, named CluRender, to learn transferable point-level features by leveraging uni-modal information for soft clustering and cross-modal information for neural rendering. Soft clustering enables self-training through a pseudo-label prediction task, where the affiliation of points to their clusters is used as a proxy under the constraint that these pseudo-labels divide the point cloud into approximate equal partitions. This allows us to formulate a clustering loss to minimize the standard cross-entropy between pseudo and predicted labels. Neural rendering generates photorealistic renderings from various viewpoints to transfer photometric cues from 2D images to the features. The consistency between rendered and real images is then measured to form a fitting loss, combined with the cross-entropy loss to self-train networks. Experiments on downstream applications, including 3D object detection, semantic segmentation, classification, part segmentation, and few-shot learning, demonstrate the effectiveness of our framework in outperforming state-of-the-art techniques.