bluuebunny/crossref_metadata_2025 huggingface dataset:
Surgical resection and overall survival in cT4b sinonasal non‐squamous cell carcinoma
Authors: Patel Aman M. , Haleem Afash , Revercomb Lucy , Brant Jason A. , Kohanski Michael A. , Adappa Nithin D. , Palmer James N. , Douglas Jennifer E. , Carey Ryan M.
Published: October 2024

Objective

Surgical resection is associated with higher overall survival (OS) than definitive radiotherapy (RT) or chemoradiotherapy (CRT) in cT4b sinonasal squamous cell carcinoma (SCC). Our study investigates the survival benefit of surgical resection in cT4b sinonasal non‐SCC.

Methods

The 2004 to 2019 National Cancer Database was queried for patients with cT4b sinonasal non‐SCC undergoing definitive treatment with (1) surgical resection + additional therapy (RT, chemotherapy, or both), (2) RT alone, or (3) CRT. Surgical resection + additional therapy and definitive RT/CRT were compared with Kaplan–Meier and multivariable Cox regression models.

Results

Of 629 patients satisfying inclusion criteria, 513 (81.6%) underwent surgical resection + additional therapy and 116 (18.4%) underwent definitive RT/CRT. The most frequent histologic types were undifferentiated carcinoma (23.7%), adenoid cystic carcinoma (22.6%), and adenocarcinoma (20.7%). Few patients presented with clinical nodal metastasis (15.7%). There were 4 (0.8%) mortalities within 90 days of surgical resection. Patients undergoing surgical resection with positive surgical margins had higher 5‐year OS than those undergoing definitive RT/CRT (56.3% vs. 39.4%, p = .039) and similar 5‐year OS as those with negative margins (56.3% vs. 63.9%, p = .059). Patients undergoing neoadjuvant chemotherapy had similar 5‐year OS as those undergoing definitive RT/CRT (60.9% vs. 39.5%, p = .053). Age at diagnosis, tumor diameter, and surgical resection + additional therapy (aHR 0.64, 95% CI 0.45–0.91) were associated with OS (p < .05).

Conclusion

Surgical resection + additional therapy was associated with higher OS than definitive RT/CRT in cT4b sinonasal non‐SCC. Surgical resection may benefit select patient with cT4b sinonasal non‐SCC.

Level of Evidence

4.
High Luminescence Saturation Y3Al5O12: Ce3+‐Diamond Composite Color Converter for High‐Brightness Laser‐Driven White Lighting
Authors: Yu Zikang , Li Jiayu , Zhao Jiuzhou , Zhang Hongjin , Mou Yun , Dai Jiangnan , Chen Mingxiang , Peng Yang
Published: October 2024

Phosphor‐converted laser lighting confronts enormous challenges in the development of color converters with high luminescence saturation owing to the thermal issues from laser irradiation and phosphor conversion. Herein, a high luminescence saturation Y3Al5O12: Ce3+‐diamond (YAG‐diamond) composite color converter by introducing diamond particles in phosphor‐in‐glass film (PiGF) coated on transparent sapphire substrate is proposed for high‐brightness laser‐driven white lighting. By optimizing the diamond content to 6 wt.%, the YAG‐diamond converter shows a thermal conductivity (TC) of 14.7 W·m−1·K−1 and displays higher luminescence intensity at 175 °C (1.15 times that at 25 °C). Under laser excitation, the YAG‐diamond converter achieves a luminous flux (LF) of 1990 lm at the laser power density (LPD) saturation threshold (ST) of 24.82 W·mm−2, which is far better than the PiGF@sapphire converter with a LF of 1364 lm@17.64 W·mm−2. The laser‐driven converter yields stable white laser light with a correlated color temperature (CCT) of 5714 K and a chromaticity coordinate of (0.3278, 0.3372) at the ST of 24.82 W·mm−2. Furthermore, the working temperature of the converter is decreased by 59 °C (26.6%) under LPD of 10.89 W·mm−2. These results indicate that the proposed YAG‐diamond composite converter displays excellent opto‐thermal performances, which may be a promising luminescence material in high‐brightness white laser lighting.
VA's EHR transition and health professions trainee programs: Findings and impacts of a multistakeholder learning community
Authors: Brunner Julian , Ahlness Ellen A. , Anderson Ekaterina , Molloy‐Paolillo Brianne K. , Braga Alexandre , Cutrona Sarah L. , Helfrich Christian D. , Levy Deborah , Matteau Erin , Walton Edward , Sayre George , Rinne Seppo T.
Published: October 2024

Introduction

The Department of Veterans Affairs (VA) is undergoing an unprecedented electronic health record (EHR) transition, switching from its homegrown EHR to a commercial system. The transition affects nearly every clinical employee but is particularly disruptive to health professions trainees (HPTs)—an often‐overlooked population in EHR transitions. To better understand and address trainee challenges with the EHR transition, we formed a multistakeholder learning community. In this study, we describe the findings of this learning community and the practices and policies developed in response.

Methods

In the qualitative study designed and executed by our learning community, we conducted 51 interviews with HPTs, program leaders, and preceptors before and multiple times after an EHR transition site's go‐live (February 16, 2022 to April 7, 2023). We merged interview transcripts with 125 survey free‐text responses from a survey conducted with preceptors 2 months post‐go‐live and conducted thematic analysis to identify key themes. To complement qualitative findings, we also include a quantitative survey finding, and, where applicable, we note policy and practice responses spurred by our learning community.

Results

Interviews yielded six key themes: (1) High satisfaction with HPT programs, despite negative impacts of the EHR transition; (2) early delays, then substantial improvements, in HPTs' EHR access; (3) persistent challenges with HPTs' EHR training and support, mitigated by local and national efforts; (4) the challenge of learning to use a rapidly evolving EHR during clinical training; (5) reduced visit volume as a continuing barrier to education; and (6) an impression that HPTs' relative lack of exposure to the prior EHR facilitated their proficiency with the new EHR.

Conclusions

Findings highlighted challenges for HPT programs related to the EHR transition, which spurred important changes including the creation of a national VA council to represent the needs of HPTs in the EHR transition, and improvements to HPTs' EHR training and access.
Withania coagulans root powder effect on growth, hematology, digestive enzyme activity, antioxidant status, serum immune response, and tolerance against Aeromonas hydrophila in Common Carp
Authors: Afzal Wajeeha , Naz Saira , Ujan Javed Ahmed , Rind Khalid Hussain , Habib Syed Sikandar , Ullah Mujeeb , Zahid Muhammad , Attaullah Sobia , Mohany Mohamed , Nazir Shahid
Published: October 2024

Objective

The use of plant-derived products in aquaculture has garnered considerable attention due to their potential benefits. This study investigated the impact of supplementing Withania coagulans root powder (WCRP) in the diet of Common Carp Cyprinus carpio on various parameters, including growth performance, digestive enzymes, hematology, antioxidant activity, and immunological aspects.

Methods

Common Carp (mean weight ± standard deviation = 11.69 ± 0.48 g) were divided into four groups in triplicate, receiving different WCRP concentrations (0.0, 1.0, 1.5, and 2.0%; labeled as WCRP0, WCRP1.0, WCRP1.5, and WCRP2.0, respectively) over a 60-day period, followed by an experimental challenge with Aeromonas hydrophila to assess the relative percentage survival (RPS) over 14 days.

Result

Results showed that Common Carp receiving WCRP1.5 and WCRP2.0 demonstrated significantly improved growth performance, with reduced feed conversion ratios (FCRs) being particularly evident in WCRP1.5. Polynomial contrasts indicated significant linear and quadratic effects on weight gain and FCR. Additionally, WCRP1.5 and WCRP2.0 supplementation led to significantly higher activity of digestive enzymes (lipase and protease). Hematological parameters, including white blood cells, red blood cells, hemoglobin, and hematocrit, were significantly elevated in fish that were fed WCRP1.5 and WCRP2.0 compared to the control group. Moreover, serum parameters, such as total protein, albumin, globulin, lysozyme, catalase, superoxide dismutase, and total immunoglobulins, were significantly enhanced in WCRP1.5- and WCRP2.0-treated fish. Notably, the WCRP1.5 group showed the lowest serum cortisol levels. The RPS was highest in WCRP1.5 (73.77%), followed by WCRP2.0 (70.43%), compared to the other groups.

Conclusion

In conclusion, supplementation with WCRP1.5 and WCRP2.0 effectively improved both growth and health parameters in Common Carp.
Transitioning to oral feeding: A retrospective cohort study of a family‐centered, hunger‐based tube weaning program
Authors: Stokes Rochelle H. , Willms Anna L. , Cowie Heather K. , Browes Alison , Karamali Soleina , Avinashi Vishal , Zwicker Jill G.
Published: October 2024

Background

We investigated the effectiveness of a novel, hunger‐based outpatient tube weaning program for children with feeding‐tube dependency.

Methods

This interdisciplinary program induced hunger via rapid reduction in tube‐fed calories, followed by 2 weeks of daily outpatient mealtime support and regular follow‐up. Forty‐one children (6.9 months to 12.8 years) participated in this retrospective cohort study.

Results

Before the program, children received a median of 90.0% (interquartile range [IQR]: 75.0%–100%) of caloric intake via tube feeds. At the end of the 2‐week program, children received 16.0% (IQR: 0.0%–30.0%) of caloric intake via tube feeds, which further reduced to 1.5% (IQR: 0.0%–33.0%) at 6‐months, and 0.0% (IQR: 0.0%–35.0%) at 1‐year follow‐up. The percentage of participants who ate >30 different foods increased from 4.9% at baseline to 81.5% at 1‐year follow‐up. The baseline median weight z score of −1.24 (IQR: −1.69 to −0.69) decreased to −1.81 (IQR: −2.77 to −1.02) at 1‐year follow‐up. A linear mixed‐effects model demonstrated that weight z score was significantly higher at baseline and 2‐weeks compared to the 1‐year follow‐up (P < 0.001 and P = 0.001, respectively), but was not significantly different between 6 months and 1 year (P = 0.44). Age was not associated with percentage of caloric intake via tube feeds or number of foods eaten.

Conclusion

Children who participated in the hunger‐based tube‐weaning program had increased and more varied oral intake 1 year following the intervention. The median weight z score decreased over the year after intervention but did not significantly decrease between 6 and 12 months after the program.
Lightweight Flow‐Based Policy Enforcement for SDN‐Based Multi‐Domain Communication
Authors: Sabur Abdulhakim
Published: October 2024

Although software‐defined networking (SDN) is commonly employed for intra‐domain communication, inter‐domain communication still heavily relies on conventional routing methods, specifically BGP‐based routers. The BGP router plays a crucial role in managing control and data planes, but this traditional approach hinders the exploitation of SDN advantages. Previous studies demonstrated the use of BGP for inter‐domain and end‐to‐end communication. This paper advocates for the adoption of a fully SDN‐based data plane packet switching strategy through the introduction of LPEES, a lightweight policy framework tailored for SDN‐based inter‐domain communication. LPEES strategically confines BGP's functionality to the control plane, preserving SDN benefits. Evaluation results confirm the effectiveness of LPEES compared to the BGP routing approach, as measured by throughput and various network quality of service (QoS) metrics. Additionally, LPEES streamlines inter‐domain communication by utilizing a trust‐based routing policy approach that can establish trust between communicating domains. The presented solution's main advantage is that it loosens the burden on the administrator by requiring less human interference to check the inter‐domain communication security and privacy. Our evaluations show LPEES outperform the BGP‐based in terms of throughput as LPEES achieves a 27 Gbps versus 22 Gbps in the traditional approach. Based on our experiments, LPEES also enhances the communication delay by an average of 17% compared to the traditional BGP‐based approach.
An Improved Two‐Step Method for Inverse Eigenvalue Problems
Authors: Yang Xinge , Shen Weiping , Guo Rui , Lou Enping
Published: October 2024

In this article, we investigate the numerical solutions of the inverse eigenvalue problem (IEP). Motivated by the techniques of Aishima in 2018, we propose here an improved two‐step method for the IEP. Compared with other existing methods, the proposed method has higher convergence order and/or requires less operations. Under the assumption that the relative generalized Jacobian matrices at a solution are nonsingular, the proposed method is proved to be convergent with cubic root‐convergence rate. Numerical examples demonstrate the effectiveness of the improved method.
Topological transport of a classical droplet in a lattice of time
Authors: Simula Tapio , Kjærgaard Niels , Pfau Tilman
Published: October 2024

Thouless charge pumps are quantum mechanical devices whose operation relies on topology. They provide the means for transporting quantum matter in space lattices with a single quantum precision. Contrasting space crystals that spontaneously break a continuous spatial translation symmetry and form crystals in space, time crystals have emerged as novel states of matter that organise into time lattices and spontaneously break a discrete time translation symmetry. The utility of Thouless pumps that enable topologically protected quantised transport of electrons and neutral atoms in spatial superlattices leads to the question if corresponding devices exist for time crystals. Here we show that topological pumps can be realised for time solids by transporting droplets of a liquid forward and backward in time lattices and we measure the topological index that characterises such pumping processes. By exploiting a synthetic time dimension, classical time crystals can circumvent the quantum tunnelling that underpins Thouless charge pumps. Our results establish topological pumping through time instead of space and pave the way for applications of time crystals.

Key Points

Periodically driven fluid droplets can be made to bounce persistently in a gravitational field and may undergo spontaneous time translation symmetry breaking forming classical time crystals.

These classical time crystals can be pumped from one time site to another, and this pumping process is characterised by a topological index.

Our observations establish a classical temporal counterpart to Thouless pumping of quantum particles in space lattices.
Preference Signals and Interview Invitations: Insight Into Recent Updates to the Oto‐HNS Residency Application Process
Authors: Duggal Radhika , Osborne Kyra , Kominsky Alan , Tierney William S.
Published: October 2024

Objective

While students in the 2023 Otolaryngology–Head and Neck Surgery (Oto‐HNS) residency match were allowed 7 preference signals, this number increased to 25 for the 2024 match with the goal of reducing the overall application volume. We sought to understand the impact of this change to application volume and interview patterns.

Study Design

Cross‐sectional survey.

Setting

Program directors of US Oto‐HNS residency programs were invited to participate in an anonymous, electronic survey.

Methods

An anonymous REDCap questionnaire was sent via email to all current Oto‐HNS program directors in January 2024. Data were analyzed using R Version 4.3.1.

Results

Forty‐four program directors completed the survey. While programs received a median [interquartile range] of 400 [363, 445] applications last year, this year they reported receiving 295 [233, 339] applications of which a median of 110 applicants (40%) signaled the program. While the median percent of applicants who were interviewed by a program was 16%, the percent of interviews among applicants who had signaled the program was 37%. Of all interviews, nearly all (median 100% [91, 100]) were of applicants who had signaled the program. Finally, 40 (91%) of program directors reported that signaling played an important role in deciding to interview a candidate.

Conclusion

Preference signals play an important role in a residency program's decision to interview a candidate. Our findings suggest that the implementation of preference signals successfully decreased the average number of applications received by each program and that medical students applying to more programs than available signals may experience diminishing returns.
Systematic Review of the Profunda Artery Perforator Free Flap for Head and Neck Reconstruction
Authors: Wilson Renita , Cave Taylor , Entezami Payam , Ware Erin , Chang Brent A.
Published: October 2024

Objective

The profunda artery perforator (PAP) flap has gained popularity in head and neck reconstruction with a favorable donor site providing a relatively hidden scar and the ability to harvest a large amount of pliable tissue with consistent vascular anatomy. The primary aim of this study is to evaluate the safety and efficacy of this PAP flap in head and neck reconstruction.

Data Sources

PUBMED, EMBASE, Web of Science, Google Scholar (January 1948‐February 2022).

Review Methods

A systematic review of the English language literature was conducted for studies with at least 3 patients 18 years or older undergoing head and neck reconstruction utilizing the PAP. Study quality and risk of bias were evaluated using the MINORS scoring system. Main analysis endpoints were flap failure rate, donor site morbidity, and complication rate.

Results

Nine articles and 206 total PAP flaps were included. The rate of flap‐related and medical complications was 33%, with only 2 (0.97%) instances of complete flap failure. Other complications included partial flap failure (10, 4.86%) and donor site wound complications (12, 5.83%). A total of 16 flaps (7.77%) required subsequent revision in the operating room. Average MINORS score of the studies suggested a moderate to high risk of bias.

Conclusion

Based on limited quality evidence, this review suggests that the PAP flap is a safe and feasible tool for head and neck reconstruction, with comparable complication and success rates as other free flaps. Further large‐scale studies are warranted.
Legal Constraints or Aggregate Individual Characteristics? Examining Factors of State R&D Intensity and Spending in the United States
Authors: Kim Koomin
Published: October 2024

This study empirically examines the impacts of legal constraints and aggregate individual characteristics on the funding and expenditure related to states' research and development (R&D). A system generalized method of moments (GMM) analysis is performed over a 20‐year period (2000–2019). The budgetary institutions, including rainy‐day funds, TELs, and debt limitations, significantly affect states' overall innovative capacity and R&D spending. They can hinder improvements in states' innovative capacity and R&D expenditure. On the other hand, states can circumvent these institutions and increase their R&D intensity and spending. States' development and human capacity foster their innovative capacity and R&D spending. Catholic work ethic is also crucial for enhancing state governments' innovative capacity and R&D expenditure. Legislative term limits reduce states' R&D intensity and expenditure. Meanwhile, economic downturns may motivate additional spending on R&D activities to promote states' innovative capacity and R&D spending. Fiscal burdens can prevent states from investing in R&D.
On a drift‐diffusion model for perovskite solar cells
Authors: Glitzky Annegret
Published: October 2024

We introduce a vacancy‐assisted charge transport model for perovskite solar cells. This instationary drift‐diffusion system describes the motion of electrons, holes, and ionic vacancies and takes into account Fermi–Dirac statistics for electrons and holes and the Fermi–Dirac integral of order for the mobile ionic vacancies in the perovskite. The free energy functional we work with corresponds to that choice of the statistical relations. To verify the existence of weak solutions, we consider a problem with regularized state equations and reaction terms on any arbitrarily chosen finite time interval. We motivate its solvability by time discretization and passage to the time‐continuous limit. A priori estimates for the chemical potentials that are independent of the regularization level ensure the existence of solutions to the original problem. These types of estimates rely on Moser iteration techniques and can also be obtained for solutions to the original problem.
An explicit time integration method for Boussinesq approximation
Authors: Rueda Castillo Dandy , Kaya Utku , Richter Thomas
Published: October 2024

This paper presents a novel approach to the discretization of the Boussinesq equation using finite elements, coupled with an explicit pressure correction scheme. The entire numerical scheme is formulated exclusively in terms of matrix‐vector products, enabling a highly efficient numerical solution. The key advantage of this approach lies in its suitability for fast computations and seamless parallelization on graphics processing units (GPUs). We present the numerical scheme and discuss different computational examples.
Low‐rank approximations of frequency‐limited discrete‐time Gramians
Authors: Kürschner Patrick
Published: October 2024

We consider the approximate computation of Gramians of large‐scale linear discrete‐time state‐space systems. Of particular interest are the Gramians which arise in frequency‐limited balanced truncation model order reduction. While there are many results for the continuous‐time situation, the discrete‐time scenario is usually considered to a much lesser extent. The Gramians are solutions of discrete‐time Lyapunov matrix equations (also called Stein matrix equations) which, if the reduction is restricted to smaller frequency intervals, also incorporate matrix functions in the form of matrix logarithms. We discuss the efficient numerical handling of these matrix function as well as the computation of low‐rank Gramian approximation by rational Krylov subspace and related iterative methods.
Catatonia in Intellectual Disability: A Case Discussion Exploring Confounding Factors and Challenges in Diagnosis
Authors: Gibbard Harriet , Cole Jenny , Varnish Ella , Muthukrishnan Sabarigirivasan
Published: October 2024

The rare psychiatric phenomenon of catatonia has recently been decoupled from schizophrenia in the ICD‐11 and DSM‐V and is now a stand‐alone syndrome. This article explores a complex case of catatonia in intellectual disability, considering a broad array of differential diagnoses for the underlying pathology. The authors also explore evolutionary theories of catatonia and consider the compounding factors resulting in delayed diagnosis and treatment.
Olanzapine‐Induced Pedal Oedema With Delayed Resolution: A Case Report and Review of Literature
Authors: Ogungbemi Oluwabunmi , Alex Rajesh K.
Published: October 2024

Olanzapine can have a better impact on negative symptoms of schizophrenia with reduced motor side effects compared to other atypical antipsychotics, according to some literature. Here, the authors describe a case of a woman with a diagnosis of schizophrenia who developed the rare side effect of bilateral pedal oedema while on oral olanzapine. The possible mechanism behind the condition and the clinical management measures taken to resolve the oedema is discussed.
Tailoring the Mechanical Properties and Foaming Behaviors of PLA/P4HB Blends by Using P4HB‐g‐GMA as Compatibilizer
Authors: Li Mingjiao , Chen Xinyi , Feng Qiyang , Fan Wanyi , Ding Yitong , Kan Ze , Li Zhibo
Published: October 2024

Synthetic poly(4‐hydroxybutyrate) (P4HB), a flexible and biodegradable polymer, shows great promise in improving the toughness of poly(lactic acid) (PLA), but the inherent immiscibility of PLA and P4HB compromises the toughening efficiency. To address this issue, P4HB grafted glycidyl methacrylate (P4HB‐g‐GMA) is synthesized for the purpose of enhancing the compatibility within the PLA/P4HB blend. The epoxy groups on P4HB‐g‐GMA can form strong chemical bonds with PLA chains and remain compatible with P4HB. Rheological data confirm that adding P4HB‐g‐GMA enhances polymer chain entanglement. Therefore, the phase interface of the blend becomes more diffuse, leading to improved mechanical performance. Specifically, a 3D‐printed PLA/P4HB/P4HB‐g‐GMA blend containing 8% P4HB‐g‐GMA (PLA/P4HB/G8) achieves an elongation at break of 161.5%, approximately 22.7 times higher than that of a PLA/P4HB blend without the modifier. Moreover, the PLA/P4HB/G8 blends show a higher volume expansion ratio (VER) and better cell morphology due to the increased melt strength from P4HB‐g‐GMA. This study demonstrates a simple and efficient method to improve the compatibility between PLA and P4HB, resulting in superior mechanical performance of PLA/P4HB blends and broadening their potential applications in foaming.
Effects of Mobile Application‐Based Cognitive Behavioral Therapy on Psychological Outcomes in Women Treated for Breast Cancer: A Randomized Controlled Pilot Trial in Germany
Authors: Heinrich Ria , Schilling Georgia , Wojtyna Ewa , Arnold Dirk , Geisler Mareike , Kley Susanne , Grudzinski Piotr , Księżak Małgorzata , Schoenfelder Tonio
Published: October 2024

Objective

Breast cancer has a strong impact on the mental state of those affected. Cognitive behavioral therapy (CBT) is one effective approach to reduce disease burden. This randomized controlled pilot trial aimed to assess the effect of the digital CBT‐based application Living Well on psychological outcomes in a German female breast cancer population.

Methods

Female breast cancer patients (n = 70) with ongoing or finished oncological treatment that is who were receiving or had received any type of oncological treatment were included in the study and randomized to an intervention group (IG, n = 32) receiving Living Well in addition to care as usual, and a control group (CG, n = 38) receiving care as usual only. Participants completed standardized questionnaires at baseline and after 2, 4, 8, and 12 weeks to assess anxiety and depression (HADS) as primary outcomes, distress (DT), health‐related quality of life (HRQoL, AQoL‐8D), and illness perception (B‐IPQ) as secondary outcomes.

Results

After 12 weeks, significant (p < 0.05) higher improvements in the IG could be observed in anxiety levels, HRQoL, and illness perception, when compared to the CG. Age and time since diagnosis were found to be relevant covariates for anxiety levels. In distress levels, the IG showed a clinically relevant and nearly significant reduction compared to the CG (p = 0.057). No effects could be observed in depression levels.

Conclusions

The results demonstrate the potential of Living Well to improve psychological outcomes of female breast cancer patients and encourage further studies evaluating the effectiveness of the digital application.

Trial Registration: The trial has been registered in the German Clinical Trials Register (DRKS00029918)
Recent Advances (2018–2023) and Research Opportunities in the Study of Groundwater in Cold Regions
Authors: Lemieux Jean‐Michel , Frampton Andrew , Fortier Philippe
Published: October 2024

Increasing greenhouse gas levels drive extensive changes in Arctic and cold‐dominated environments, leading to a warmer, more humid, and variable climate. Associated permafrost thaw creates new groundwater flow paths in cold regions that are causing unprecedented environmental changes. This review of recent advances in groundwater research in cold environments has revealed that a new paradigm is emerging where groundwater is at the center of these changes. Groundwater flow and associated heat and solute transport are now used as a basis to understand hydrological changes, permafrost dynamics, water quality, integrity of infrastructure along with ecological impacts. Although major advances have been achieved in cold regions' cryohydrogeological research, the remaining knowledge gaps are numerous. For example, groundwater as a drinking water source is poorly documented despite its social importance. Lateral transport processes for carbon and contaminants are still inadequately understood. Numerical models are improving, but the highly complex physical‐ecological changes occurring in the arctic involve coupled thermal, hydrological, hydrogeological, mechanical, and geochemical processes that are difficult to represent and hamper quantitative analysis and limit predictive capacity. Systematic long‐term observatories where measurements involving groundwater are considered central are needed to help resolve these research gaps. Innovative transdisciplinary research will be critical to comprehend and predict these complex transformations.
Improving implementation and team communication by integrating a cystic fibrosis transition readiness (CF R.I.S.E.) program into electronic health records
Authors: Enochs Catherine , Filbrun Amy G. , Hjelm Michelle , Lehrmann Julie , Mullen Lisa , Packard Rebeca , Roach Jessica , Saulitis Anna K. , Nasr Samya Z.
Published: October 2024

Background

The cystic fibrosis (CF) Responsibility. Independence. Self‐care. Education. (R.I.S.E.) program was developed to provide assessment and education, supporting transition readiness for people with cystic fibrosis (pwCF). Lack of integration within electronic health records (EHR) was a barrier to implementation of CF R.I.S.E. University of Michigan was able to integrate CF R.I.S.E. into EHR.

Aim

To improve implementation and EHR documentation of CF R.I.S.E. module completion by pwCF across two (CF) programs from baseline (10.5%) to 75% per month in 6 months (January through June 2023).

Methods

Two CF programs utilized quality improvement (QI) methods and tools and ad hoc support by a CF Learning Network (QI) specialist. Eligibility included pwCF ≥16 years old seen in CF clinics who accepted CF R.I.S.E. participation. Beginning January 2, 2023, programs met in biweekly, virtual meetings to discuss implementation. Deidentified data were collected monthly tracking modules completed by pwCF and number of team members engaging with CF R.I.S.E. and documenting in EHR. Data timelines were baseline (November–December 2022), project period (January–June 2023), and post‐project (July–December 2023).

Results

Completion rates increased from baseline (10.5%) to 48% (range 33% to 81%) through December 2023. During the project, an average 7.7 team members completed an average 19.2 modules per month. Post‐project, an average 8 team members completed an average 16.5 modules per month.

Conclusions

This collaboration demonstrated how utilization of EHR allowed for successful CF R.I.S.E. improvement at both programs. Shared software utilization and QI initiatives may be a way to facilitate timely dissemination of best practices through learning health systems.
Artists' satisfaction with telerehabilitation in physiotherapy during the COVID‐19 pandemic: A cross‐sectional study
Authors: Jiang Coco , de Youngster Sesinam , Hawkins Vicki , Li Shelly‐Anne
Published: October 2024

Background and Purpose

To our knowledge, there is currently no research on telerehabilitation concerning artists. This study aims to assess the feasibility, acceptability, and effectiveness of utilizing video‐based telerehabilitation in physiotherapy among artists during the COVID‐19 pandemic.

Methods

Fifty‐one artists who accessed virtual physiotherapy between November 2020 and February 2022 at a healthcare center that provides specialized healthcare services to artists of all disciplines who reside or work in Ontario, Canada were asked to complete a 26‐item online questionnaire about their experience with virtual physiotherapy.

Results

The 51 respondents were from a range of artistic disciplines, with the largest portion being musicians (n = 22; 43%). Of the respondents, 86% (n = 44) felt the virtual physiotherapy met their expectations in therapeutic benefits, 78% (n = 40) were confident in performing all the exercises that the physiotherapist demonstrated on the virtual platform, 80% (n = 41) did not run into many technological challenges when booking or attending virtual sessions, and 54% (n = 20) reported similar treatment outcomes between virtual and in‐person sessions. Although artists liked the convenience of accessing physiotherapy from home, 53% (n = 17) of respondents rated the lack of physical contact as a major limitation in telerehabilitation.

Conclusion

Telerehabilitation for artists during the COVID‐19 pandemic has shown potential to be an effective and viable alternative to in‐person physiotherapy, as demonstrated by high satisfaction levels and comparable treatment outcomes, especially when public health restrictions were in place. Future research can explore hybrid models (mix of in‐person and virtual sessions) in physiotherapy to meet the needs for physical contact during sessions.
Real‐Time Nuclear Magnetic Resonance Detection Using Maximum Likelihood Estimation with Single‐Shallow‐Nitrogen‐Vacancy Centers in Quantum Heterodyne Measurements
Authors: Chanuntranont Akirabha , Saito Daiki , Otani Kazuki , Ota Tomoki , Ueda Yuki , Tsugawa Masato , Usui Shuntaro , Miyake Yuto , Teraji Tokuyuki , Onoda Shinobu , Shinada Takahiro , Kawarada Hiroshi , Tanii Takashi
Published: October 2024

Single‐nitrogen‐vacancy (NV) centers in diamond are highly promising quantum nuclear magnetic resonance (NMR) sensors. However, their exposure to many sources of noise, such as surface impurities, shot noise from avalanche photodiode overlaps, and spin‐state projection errors inherent in quantum systems, limits their usefulness. Often, long measurement durations are required to accumulate sufficient data for NMR signal detection via fast Fourier transform spectrometry. For practical reasons, methods to shorten the necessary accumulation time for NMR signal detection are greatly desired. In this article, an on‐line formulation of maximum likelihood estimation (MLE) signal processing for quantum heterodyne NMR measurements is presented as a step toward this goal. This MLE method reduces the required data accumulation time by orders of magnitude and provides good estimates of target frequency locales in real time. These results are significant to practitioners of NMR detection with single‐NV centers in diamond who require a quick litmus test for potential signals when probing a wide area.
Bridging the Technology Gap for Cost‐Effective and Sustainable Treatment of Per‐ and Polyfluoroalkyl Substances in Surface Water and Stormwater
Authors: Gamlin Jeff D. , Javed Hassan , Newell Charles J. , Stockwell Emily , Caird Renee , Scalia Joseph , Navarro Divina , Awad John
Published: October 2024

This article addresses the urgent need for cost‐effective and sustainable methods to mitigate per‐ and polyfluoroalkyl substances (PFAS) contamination in surface water and stormwater. Although the majority of PFAS research and development to date has focused on groundwater and soil treatment technologies, in some cases there may be a greater risk posed by the high mobility and potential for direct contact with PFAS in surface water and stormwater. Based on the evolving regulatory landscape and the elevated PFAS concentrations observed in available stormwater data near some fire training facilities, additional attention to this topic is needed to support the development of effective and practical treatment technologies for PFAS in surface water and stormwater. We propose addressing the need to bridge the current technology gap between (1) expensive mechanical and/or construction‐intensive technologies and (2) the development of cost‐effective and sustainable surface water and stormwater PFAS treatment options. We envision a future where nature‐based approaches could be employed for stand‐alone PFAS treatment. Alternatively, nature‐based approaches could be used for initial PFAS mass removal as a pretreatment step within a treatment train followed by engineered adsorbents or other technologies, if needed to achieve low concentration cleanup thresholds. We provide an example of a potential nature‐based treatment train that would rely on the natural propensity of PFAS to accumulate in surface water foams using foam‐enhancing weirs and flumes (FWFs), combined with the demonstrated treatment potential of constructed floating wetlands (CFWs). Additional research into the validation, optimization, and site‐specific design factors of nature‐based treatment trains, such as the FWF+CFW approach, warrants future research and development.
A methodology for prioritizing sustainable development goals targets at the local level: The case of Barcelona City Council
Authors: Urquijo‐Reguera Julia , Illán Sailer José Carlos , Trobat Llompart Miquel , Canal Oliveras Ramon
Published: October 2024

The implementation of the 2030 Agenda relies heavily on the active involvement of local governments. The concept of “Localization”—the process of adapting and customizing the SDGs and translating them into local development plans and strategies—has gained prominence as governments address emerging challenges, necessitating innovative approaches. Practical insights from local governments are essential for guiding others in this process. A key debate focuses on “prioritization,” emphasizing the need to focus on a specific set of SDG targets based on available resources, the local government's experience with sustainable policies or the normative framework in which it operates. Prioritization is crucial to prevent fragmentation of efforts that could hinder the local government's contribution to the 2030 Agenda. This paper aims to introduce a methodology for prioritizing SDG targets within local governments. Using a multicriteria analysis tool, the paper shows the process undertaken by the Barcelona City Council to cluster the SDG targets around four priority groups based on four criteria: (i) distance to the goal, (ii) strategic coverage, (iii) normative competence, and (iv) budgetary effort. The prioritization approach contributes to a better monitoring and evaluation process to assess progress towards the SDGs and enhance collaborative efforts across municipal policy and management levels. The findings provide valuable insights and serve as a reference for other local governments aiming at contributing to the 2030 Agenda. The approach is adaptable and can be applied to different subnational governments by tailoring to their specific scope and requirements of the context of application.
Metal Ions Modified Azo‐Linked Porous Polymers for High Performance CO2 Capture
Authors: Pei Bo , Chu Dongdong , Huang Jiajia
Published: October 2024

Porous polymer show great potential for CO2 capture owing to its high specific surface area, adjustable porous structure and chemical structure. Herein, a novel CO2 adsorption materials ALP−M (M: Cu2+, Mg2+, Ni2+) were prepared through coordination between azo‐linked porous polymer (ALP) synthesized by oxidative coupling polymerization of tris(4‐aminophenyl)amine and metal ions. The structures and morphology of as‐prepared materials were demonstrated by FT‐IR, XRD, XPS, BET and SEM, the CO2 capture performance and mechanism of ALP−M were also investigated through static adsorption and column adsorption experments, the results show that metal ions can enhance the CO2 adsorption and desorption performance of ALPs by coordination adsorption. ALP−M showed a highest static CO2 adsorption capacity of 2.67 mmol g−1 at 273 K (1 bar), which is 35.5 % higher than that of ALP. The metal ions served as Lewis acid sites can enhance the affinity of adsorbent for CO2. In column adsorption experiments, the ALP−M showed a higher saturated adsorption capacity 4.99 mmol g−1 at 273 K (1 bar) than that of static adsorption, and excellent cycling stability after 500 adsorption and desorption cycles, the adsorption capacity retention rate of ALP−M for CO2 can reach 98 %.
In Silico Screening of FDA‐Approved Anthelmintic Drugs Against LuxR Protein as Quorum‐Sensing Inhibitors and Exploration of Their Binding Mechanism and Electronics Properties
Authors: Paswan Uttam , Basak Hriday Kumar , Saha Soumen , Chatterjee Abhik
Published: October 2024

Treating bacterial infections triggered by multidrug‐resistant bacteria is a global priority. Issue of multidrug resistance can be managed by inhibiting bacterial quorum sensing mechanism. Quorum‐sensing inhibitors (QSIs) are promising alternatives to antibiotics. Herein, a library of FDA‐approved anthelmintic medications was screened using in silico techniques for LuxR protein associated with the quorum‐sensing (QS) mechanism of Staphylococcus aureus. Drug repurposing can reduce the time and financial risk of drug development. Seven FDA‐approved drugs (Fenbendazole, Mebendazole, Flubendazole, Praziquantel, Oxyclozanide, Rafoxanide, and Albendazole) showed strong binding affinity to the LuxR protein with binding free energy less than −6.00 kcal/mol. Molecular dynamic simulation (100 ns) of the docked complexes revealed that Fenbendazole and Rafoxanide remain at the binding pocket of the LuxR protein most of the time. During the whole simulation period, backbone of all seven complexes displayed small fluctuation in the RMSD and Rg. The free energy landscape of LuxR–Rafoxanide and LuxR–Fenbendazole complexes showed promising stability compared to the rest of the complexes. Both the complexes showed excellent MMPBSA binding free energy: −92.882 ± 15.636 kJ/mol (LuxR–Rafoxanide) and −74.873 ± 9.233 kJ/mol (LuxR–Fenbendazole). The reactivity of the ligands was ascertained from their DFT‐based various descriptors.
Simple and Highly Sensitive Electrochemical Sensor for Sunset Yellow Detection Based on Co3O4/g‐C3N4 Nanocomposite Modified Gold Electrode
Authors: Sundaresan Sumi , Sowmya Subramanian , Vijaikanth Vijendran
Published: October 2024

Sunset Yellow (SY) is an azo dye used in various food and pharmaceutical industries that deserves special attention because of its allergic and carcinogenic properties. Recently, electrochemical techniques have come to the spotlight because of their high sensitivity, simplicity and rapidity as compared to other techniques. In this work, we have developed a cost‐effective and stable electrochemical sensor by a simple method using Vitamin B12‐derived cobalt oxide coupled with g‐C3N4 (V12‐CoO/gCN) modified Au electrode. The composite prepared for the sensor was characterized using techniques such as FTIR, Powder XRD, SEM analysis, EDAX, and mapping. For electrochemical sensing of the dye Sunset Yellow, CV, DPV, and LSV techniques have been used, out of which DPV shows a better detection limit of 1.39 nM followed by LSV and CV that displayed detection limits of 3.3 nM and 4.14 nM respectively. When 5 real samples obtained from the local market are analyzed using the DPV technique, the detection limit is obtained in the range between 2.1 nM and 6.9 nM. This method leads to the development of an electrochemical sensor for the detection of Sunset Yellow to get a lower detection limit that can be used in food toxicology and related fields.
Phytochemical Analysis and Anti‐inflammatory Potential of Floscopa Scandens Lour. and Exploring Ecdysterone as Promising Therapeutic Agent: An HR‐LCMS Screening and Molecular Docking Analysis
Authors: Nambaaru Sailaja , Sahu Preeti Nanda , Katta Sunitha , Ganapavarapu Veera Raghava Sarma , Kancharla Bhanukiran , Sen Anik
Published: October 2024

This study delved into the exploration of bioactive constituent profiling of Floscopa scandens Lour. by using HRLC‐MS. The plant is well‐known as a folklore herb. It is extensively utilized in traditional medicine to address various ailments such as fractures, sore eyes, fevers, abscesses, pyoderma, and acute nephritis. This study aimed to explore the phytochemical composition of F. scandens and assess the anti‐inflammatory activity of the ecdysterone marker compound by molecular docking studies followed by MD simulations. Extracts were prepared using hexane, chloroform, and methanol solvents. Chromatographic techniques were applied to isolate compounds from the methanol extract, which underwent phytochemical screening via HR‐LCMS. Functional groups were assessed using NMR and Fourier transform infrared (FTIR), confirming the presence of bioactive compounds. HR‐LCMS analysis identified 21 phytoconstituents in the methanolic fraction, with ecdysterone being a prominent component characterized through spectroscopic techniques. Our findings confirm known molecules while unveiling new bioactive constituents, particularly highlighting the potential of ecdysterone as a novel chemical entity. Molecular docking and molecular dynamic simulation analysis further show the anti‐inflammatory properties of ecdysterone with various enzymes in the body.
Fluorescence Sensing of Cu2+ Ion and Some Organic Pollutants by Using Katiragum Dialdehyde‐α‐Amino Acid Schiff Bases in Aqueous Medium
Authors: Saren Rakesh Kumar , Tripathy Tridib
Published: October 2024

Efficient and selective fluorescence sensors based on katiragum dialdehyde‐ amino acid Schiff's base is developed for fluorometric sensing to detect vanillin, Cu2+ ions and 4‐nitrophenol (4NP) in their aqueous solution. Two Schiff bases namely katiragum dialdehyde‐ arginine (KGDR) and katiragum dialdehyde‐ tryptophan (KGDT) are developed in the author's laboratory between which KGDR can detect vanillin with a detection limit of 60.29 nM whereas KGDT can detect both Cu2+ ion and 4NP with a detection limit of 72.6 nM and 97.83 nM respectively. KGDR and KGDT show significant quantum yields of 0.47 % and 0.25 % compared to a standard known substance fluorescein (0.97 %). The detection limit of vanillin, Cu2+ ions and 4NP are lower than other reported sensors. The developed Schiff base KGDR and KGDT show excellent recovery percentage and relative standard deviation (RSD) values in real sample analysis.
Assessing Yield Disparities: Anticipated versus Optimal Rooftop Photovoltaic Systems and Implications for Prosumer Viability
Authors: Keiner Dominik , Bogdanov Dmitrii , Krauter Stefan , Breyer Christian
Published: October 2024

Solar photovoltaics, especially rooftop systems also called distributed solar photovoltaics, are crucial in the ongoing energy transition. Modeling these systems is vital to understanding their role in a decentralized energy system. While ground‐mounted photovoltaic power plants are easier to model, generalizing yield profiles for rooftop systems is challenging. This study aims to estimate yield loss effects for rooftop solar photovoltaic systems compared to optimized ground‐mounted systems. Anticipated yield losses are 18% for residential, 7% for commercial, and 4% for industrial rooftop systems. The impact on residential prosumers’ viability is assessed by comparing prosumer system optimization results with and without yield losses. Results show a non‐uniform change in installed solar photovoltaic and battery capacities, with a tendency to compensate for reduced yields by increasing photovoltaic capacity by up to 20%, given favorable cost prospects by 2050. The annualized total cost of energy for prosumer households could therefore increase by up to 20% by 2050. Despite yield reductions, installing a solar photovoltaic prosumer system remains more favorable than relying entirely on‐grid electricity. This study highlights the importance of considering yield losses in rooftop solar photovoltaics and the significant role of prosumers despite identified yield losses.
Understanding the benefits and pitfalls of artificial intelligence
Authors: McCarthy Claudine
Published: October 2024

About half of the people who use artificial intelligence (AI) don’t want anyone else to know they use it. That's because they’re worried about seeming replaceable in their jobs, especially if they work in academia. Or they’re concerned that AI use might not be permitted or that it qualifies as some form of cheating, according to Beth Ziesenis, owner of yournerdybestfriend.com.