bluuebunny/crossref_metadata_2025 huggingface dataset:
Torus-like Solutions for the Landau-de Gennes Model. Part I: The Lyuksyutov Regime
Authors: Dipasquale Federico , Millot Vincent , Pisante Adriano
Published: October 2020

We study global minimizers of a continuum Landau-de Gennes energy functional for nematic liquid crystals, in three-dimensional domains, under a Dirichlet boundary condition. In a relevant range of parameters (which we call theLyuksyutov regime), the main result establishes the nontrivial topology of the biaxiality sets of minimizers for a large class of boundary conditions including the homeotropic boundary data. To achieve this result, we first study minimizers subject to a physically relevant norm constraint (theLyuksyutov constraint), and show their regularity up to the boundary. From this regularity, we rigorously derive the norm constraint from the asymptotic Lyuksyutov regime. As a consequence, isotropic melting is avoided by unconstrained minimizers in this regime, which then allows us to analyse their biaxiality sets. In the case of a nematic droplet, this also implies that the radial hedgehog is an unstable equilibrium in the same regime of parameters. Technical results of this paper will be largely employed in Dipasquale et al. (Torus-like solutions for the Landau- de Gennes model. Part II: topology of$$\mathbb {S}^1$$S1-equivariant minimizers.https://arxiv.org/pdf/2008.13676.pdf; Torus-like solutions for the Landau- de Gennes model. Part III: torus solutions vs split solutions (In preparation)), where we prove that biaxiality level sets are generically finite unions of tori for smooth configurations minimizing the energy in restricted classes of axially symmetric maps satisfying a topologically nontrivial boundary condition.
A Bayesian approach to analysing cortico-cortical associative stimulation induced increases in the excitability of corticospinal projections in humans
Authors: Carson Richard G. , Capozio Antonio , McNickle Emmet , Sack Alexander T.
Published: October 2020

Repeated pairing of transcranial magnetic stimulation (TMS) over left and right primary motor cortex (M1), at intensities sufficient to generate descending volleys, produces sustained increases in corticospinal excitability. In other paired associative stimulation (PAS) protocols, in which peripheral afferent stimulation is the first element, changes in corticospinal excitability achieved when the second stimulus consists of brief bursts of transcranial alternating current stimulation (tACS), are comparable to those obtained if TMS is used instead (McNickle and Carson 2015). The present aim was to determine whether associative effects are induced when the first stimulus of a cortico-cortical pair is tACS, or alternatively subthreshold TMS. Bursts of tACS (500 ms; 140 Hz; 1 mA) were associated (180 stimulus pairs) with single magnetic stimuli (120% resting motor threshold rMT) delivered over the opposite (left) M1. The tACS ended 6 ms prior to the TMS. In a separate condition, TMS (55% rMT) was delivered to right M1 6 ms before (120% rMT) TMS was applied over left M1. In a sham condition, TMS (120% rMT) was delivered to left M1 only. The limitations of null hypothesis significance testing are well documented. We therefore employed Bayes factors to assess evidence in support of experimental hypotheses—defined precisely in terms of predicted effect sizes, that these two novel variants of PAS increase corticospinal excitability. Although both interventions induced sustained (~ 20–30 min) increases in corticospinal excitability, the evidence in support of the experimental hypotheses (over specified alternatives) was generally greater for the paired TMS-TMS than the tACS-TMS conditions.
The incidence and influence of the donor corneas positive for herpesviridae DNA in keratoplasty
Authors: Qu Jing-hao , Peng Rong-mei , Xiao Ge-ge , Qu Hong-qiang , Yu Ting , Zhang Shuang , Hong Jing
Published: October 2020

Purpose

We detected the DNA of herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), varicella-zoster virus (VZV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) in donor corneas and assessed the clinical outcomes of recipients who received virus-positive grafts.

Method

All donor corneas were analyzed for the presence of HSV-1, HSV-2, VZV, CMV, and EBV by real-time PCR from April 2017 to July 2019. The medical records of the transplant patients who received virus-positive grafts were reviewed.

Result

Twenty-three (2.44%) donor cornea buttons tested positive for herpesviridae DNA. The positivity rates of HSV-1, CMV, VZV, and EBV were 0.74%, 0.85%, 0.64%, and 0.21%, respectively.

Conclusion

We suggest that the corneas from donors who had cancer, donors who were inpatients, and donors who had immunodeficiency or who were on immunosuppressive therapy should be tested for herpesviridae DNA before transplantation. Finally, HSV-1 can be transmitted from graft to recipient, but that CMV cannot be transmitted according to our observations. The donor corneas found to be HSV-1-positive have to be discarded and not used for keratoplasty.
Disease-associated HCN4 V759I variant is not sufficient to impair cardiac pacemaking
Authors: Erlenhardt Nadine , Kletke Olaf , Wohlfarth Franziska , Komadowski Marlene A. , Clasen Lukas , Makimoto Hisaki , Rinné Susanne , Kelm Malte , Jungen Christiane , Decher Niels , Meyer Christian , Klöcker Nikolaj
Published: October 2020

The hyperpolarization-activated cation current If is a key determinant for cardiac pacemaker activity. It is conducted by subunits of the hyperpolarization-activated cyclic nucleotide–gated (HCN) channel family, of which HCN4 is predominant in mammalian heart. Both loss-of-function and gain-of-function mutations of the HCN4 gene are associated with sinus node dysfunction in humans; however, their functional impact is not fully understood yet. Here, we sought to characterize a HCN4 V759I variant detected in a patient with a family history of sick sinus syndrome. The genomic analysis yielded a mono-allelic HCN4 V759I variant in a 49-year-old woman presenting with a family history of sick sinus syndrome. This HCN4 variant was previously classified as putatively pathogenic because genetically linked to sudden infant death syndrome and malignant epilepsy. However, detailed electrophysiological and cell biological characterization of HCN4 V759I in Xenopus laevis oocytes and embryonic rat cardiomyocytes, respectively, did not reveal any obvious abnormality. Voltage dependence and kinetics of mutant channel activation, modulation of cAMP-gating by the neuronal HCN channel auxiliary subunit PEX5R, and cell surface expression were indistinguishable from wild-type HCN4. In good agreement, the clinically likewise affected mother of the patient does not exhibit the reported HCN4 variance. HCN4 V759I resembles an innocuous genetic HCN channel variant, which is not sufficient to disturb cardiac pacemaking. Once more, our work emphasizes the importance of careful functional interpretation of genetic findings not only in the context of hereditary cardiac arrhythmias.
A CRISPR and high-content imaging assay compliant with ACMG/AMP guidelines for clinical variant interpretation in ciliopathies
Authors: Nazlamova Liliya , Thomas N. Simon , Cheung Man-Kim , Legebeke Jelmer , Lord Jenny , Pengelly Reuben J. , Tapper William J. , Wheway Gabrielle
Published: October 2020

Ciliopathies are a broad range of inherited developmental and degenerative diseases associated with structural or functional defects in motile or primary non-motile cilia. There are around 200 known ciliopathy disease genes and whilst genetic testing can provide an accurate diagnosis, 24–60% of ciliopathy patients who undergo genetic testing do not receive a genetic diagnosis. This is partly because following current guidelines from the American College of Medical Genetics and the Association for Molecular Pathology, it is difficult to provide a confident clinical diagnosis of disease caused by missense or non-coding variants, which account for more than one-third of cases of disease. Mutations in PRPF31 are the second most common cause of the degenerative retinal ciliopathy autosomal dominant retinitis pigmentosa. Here, we present a high-throughput high-content imaging assay providing quantitative measure of effect of missense variants in PRPF31 which meets the recently published criteria for a baseline standard in vitro test for clinical variant interpretation. This assay utilizes a new PRPF31+/– human retinal cell line generated using CRISPR gene editing to provide a stable cell line with significantly fewer cilia in which novel missense variants are expressed and characterised. We show that high-content imaging of cells expressing missense variants in a ciliopathy gene on a null background can allow characterisation of variants according to the cilia phenotype. We hope that this will be a useful tool for clinical characterisation of PRPF31 variants of uncertain significance, and can be extended to variant classification in other ciliopathies.
Managing groundwater supplies subject to drought: perspectives on current status and future priorities from England (UK)
Authors: Ascott M. J. , Bloomfield J. P. , Karapanos I. , Jackson C. R. , Ward R. S. , McBride A. B. , Dobson B. , Kieboom N. , Holman I. P. , Van Loon A. F. , Crane E. J. , Brauns B. , Rodriguez-Yebra A. , Upton K. A.
Published: October 2020

Effective management of groundwater resources during drought is essential. How is groundwater currently managed during droughts, and in the face of environmental change, what should be the future priorities? Four themes are explored, from the perspective of groundwater management in England (UK): (1) integration of drought definitions; (2) enhanced fundamental monitoring; (3) integrated modelling of groundwater in the water cycle; and (4) better information sharing. Whilst these themes are considered in the context of England, globally, they are relevant wherever groundwater is affected by drought.
A phase II study of FOLFOXIRI plus bevacizumab as initial chemotherapy for patients with untreated metastatic colorectal cancer: TRICC1414 (BeTRI)
Authors: Shinozaki Katsunori , Yamada Takeshi , Nasu Junichiro , Matsumoto Toshihiko , Yuasa Yasuhiro , Shiraishi Takeshi , Nagano Hiroaki , Moriyama Ichiro , Fujiwara Toshiyoshi , Miguchi Masashi , Yoshida Ryosuke , Nozaka Kimiyasu , Tanioka Hiroaki , Nagasaka Takeshi , Kurisu Yasuro , Kobayashi Michiya , Tsuchihashi Kenji , Inukai Michio , Kikuchi Takashi , Nishina Tomohiro
Published: October 2020

Purpose

FOLFOXIRI plus bevacizumab is regarded as a first-line therapeutic option for selected patients with metastatic colorectal cancer (mCRC). Our aim was to assess the efficacy and safety of induction treatment with FOLFOXIRI plus bevacizumab in patients with untreated mCRC harboring UGT1A1 wild (*1/*1), or single-hetero (*1/*6 or *1/*28) genotypes.

Methods

Twelve cycles of FOLFOXIRI plus bevacizumab were administered to patients with untreated mCRC. The primary endpoint was the overall response rate (ORR) assessed by central independent reviewers. Secondary endpoints included time to treatment failure (TTF), progression-free survival (PFS), overall survival (OS), relative dose intensity (RDI), R0 resection rate, and safety. The exploratory objectives were early tumor shrinkage (ETS) and depth of response (DoR).

Results

Of the 47 patients enrolled, 46 and 44 patients were eligible for the safety and efficacy analysis, respectively. The primary endpoint was met. The ORR was 63.6% (95% CI 47.8–77.6). At a median follow-up of 25.4 months, median TTF, PFS, and OS was 8.1, 15.5, and 34.4 months, respectively. The median RDI of 5-fluorouracil, irinotecan, oxaliplatin, and bevacizumab was 72, 69, 62, and 71%, respectively. R0 resection rate was 22.7%. Grade 3 or higher adverse events (≥ 10%) included neutropenia (65.2%), febrile neutropenia (26.1%), leukopenia (23.9%), anorexia (10.9%), nausea (10.9%), and diarrhoea (10.9%). No treatment-related deaths were observed. ETS and DoR were 70.5 and 45.4%, respectively.

Conclusions

FOLFOXIRI plus bevacizumab induction treatment of Japanese patients was shown to be beneficial and manageable, although caution is required since the treatment causes febrile neutropenia.
Generative Learning: Which Strategies for What Age?
Authors: Brod Garvin
Published: October 2020

Generative learning strategies are intended to improve students’ learning by prompting them to actively make sense of the material to be learned. But are they effective for all students? This review provides an overview of six popular generative learning strategies: concept mapping, explaining, predicting, questioning, testing, and drawing. Its main purpose is to review for what ages the effectiveness of these strategies has been demonstrated and whether there are indications of age-related differences in their effectiveness. The description of each strategy covers (1) how it is supposed to work, (2) the evidence on its effectiveness in different age groups, and (3) if there are age-related differences in its effectiveness. It is found that while all six generative learning strategies reviewed have proven effective for university students, evidence is mixed for younger students. Whereas some strategies (practice testing, predicting) seem to be effective already in lower-elementary-school children, others (drawing, questioning) seem to be largely ineffective until secondary school. The review closes with a call for research on the cognitive and metacognitive prerequisites of generative learning that can explain these differences.
High power and stable P-doped yolk-shell structured Si@C anode simultaneously enhancing conductivity and Li+ diffusion kinetics
Authors: Chen Ming , Zhou Qinnan , Zai Jiantao , Iqbal Asma , Tsega TsegayeTadesse , Dong Boxu , Liu Xuejiao , Zhang Yuchi , Yan Changyu , Zhao Liang , Nazakat Ali , E SharelPeisan , Low CheeTongJohn , Qian Xuefeng
Published: October 2020

Silicon is a low price and high capacity anode material for lithium-ion batteries. The yolk-shell structure can effectively accommodate Si expansion to improve stability. However, the limited rate performance of Si anodes can’t meet people’s growing demand for high power density. Herein, the phosphorus-doped yolk-shell Si@C materials (P-doped Si@C) were prepared through carbon coating on P-doped Si/SiOx matrix to obtain high power and stable devices. Therefore, the as-prepared P-doped Si@C electrodes delivered a rapid increase in Coulombic efficiency from 74.4% to 99.6% after only 6 cycles, high capacity retention of ∼ 95% over 800 cycles at 4 A·g−1, and great rate capability (510 mAh·g−1 at 35 A·g−1). As a result, P-doped Si@C anodes paired with commercial activated carbon and LiFePO4 cathode to assemble lithium-ion capacitor (high power density of ∼ 61,080 W·kg−1 at 20 A·g−1) and lithium-ion full cell (good rate performance with 68.3 mAh·g−1 at 5 C), respectively. This work can provide an effective way to further improve power density and stability for energy storage devices.
Child murder in the Early Bronze Age: proteomic sex identification of a cold case from Schleinbach, Austria
Authors: Rebay-Salisbury Katharina , Janker Lukas , Pany-Kucera Doris , Schuster Dina , Spannagl-Steiner Michaela , Waltenberger Lukas , Salisbury Roderick B. , Kanz Fabian
Published: October 2020

The identification of sex-specific peptides in human tooth enamel by nanoflow liquid chromatography-tandem mass spectrometry (nanoLC-MS/MS) represents a quantum leap for the study of childhood and social relations more generally. Determining sex-related differences in prehistoric child rearing and mortality has been hampered by the insufficient accuracy in determining the biological sex of juveniles. We conducted mass spectrometric analysis to identify sex-specific peptides in the dental enamel of a child from a settlement pit of the Early Bronze Age settlement of Schleinbach, Austria (c. 1950–1850 bc). Four perimortal impression fractures on the skull of a 5–6-year-old child indicate an intentional killing, with a co-buried loom weight as possible murder weapon. Proteomic analysis, conducted for the first time on prehistoric teeth in Austria, determined the child’s sex as male. While we cannot conclusively determine whether the child was the victim of conflicts between village groups or was slain by members of his own community, we suggest that contextual evidence points to the latter. A possible trigger of violence was the follow-on effects of an uncontrolled middle ear infection revealed by an osteological analysis. The boy from Schleinbach highlights the potential for further investigation of gender-biased violence, infanticide and child murder based on the recently developed method of proteomic sex identification.
Perceived Adverse Effects of Separating Government Institutions for Disaster Risk Reduction and Climate Change Adaptation Within the Southern African Development Community Member States
Authors: Nemakonde Livhuwani D. , Van Niekerk Dewald , Becker Per , Khoza Sizwile
Published: October 2020

Integration of disaster risk reduction (DRR) and climate change adaptation (CCA) is widely recognized as a solution for reducing the risk and impacts of disasters. However, successful integration seems elusive, and the two goals continue to function in isolation and in parallel. This article provides empirical insights into the perceived effects of separating government institutions for DRR and CCA within the Southern African Development Community member states. A mixed method research design was applied to the study. A total of 40 respondents from Botswana, Eswatini (until April 2018 Swaziland), Madagascar, Malawi, Namibia, South Africa, Tanzania, Zambia, and Zimbabwe participated in face-to-face interviews or an online survey. Five major effects of separating the organizations for DRR and CCA that impede efforts to reduce disaster risk coherently were identified: duplication of services, polarization of interventions, incoherent policies, competition for the same resources, and territorial contests. Given the continued fragmentation of institutions for DRR and CCA, highlighting these effects is important to emphasize the need for integrated approaches towards the reduction of disaster risk.
Using mobile technology in assessment of entrustable professional activities in undergraduate medical education
Authors: Duggan Norah , Curran Vernon R. , Fairbridge Nicholas A. , Diana Deacon Diana , Coombs Heidi , Stringer Katherine , Pennell Stephen
Published: October 2020

Background The adoption of competency-based medical education requires objective assessments of a learner’s capability to carry out clinical tasks within workplace-based learning settings. This study involved an evaluation of the use of mobile technology to record entrustable professional activity assessments in an undergraduate clerkship curriculum.

Approach A paper-based form was adapted to a mobile platform called eClinic Card. Students documented workplace-based assessments throughout core clerkship and preceptors confirmed accuracy via mobile phones. Assessment scores for the 2017–2018 academic year were collated and analyzed for all core rotations, and preceptors and students were surveyed regarding the mobile assessment experience.

Evaluation The mobile system enabled 80 students and 624 preceptors to document 6850 assessment submissions across 47 clinical sites over a 48-week core clerkship curriculum. Students’ scores demonstrated progressive improvement across all entrustable professional activities with stage-appropriate levels of independence reported by end of core clerkship. Preceptors and students were satisfied with ease of use and dependability of the mobile assessment platform; however, students felt quality of formative coaching feedback could be improved.

Reflection Our preliminary evaluation suggests the use of mobile technology to assess entrustable professional activity achievement across a core clerkship curriculum is a feasible and acceptable modality for workplace-based assessment. The use of mobile technology supported a programmatic assessment approach. However, meaningful coaching feedback, as well as faculty development and support, emerged as key factors influencing successful adoption and usage of entrustable professional activities within an undergraduate medical curriculum.
Alcohol-Induced Neuropathy in Chronic Alcoholism: Causes, Pathophysiology, Diagnosis, and Treatment Options
Authors: Dudek Iga , Hajduga Danuta , Sieńko Cezary , Maani Amr , Sitarz Elżbieta , Sitarz Monika , Forma Alicja
Published: October 2020

Purpose of the Review

Alcohol abuse causes a wide range of disorders that affect the nervous system. These include confusion, cerebellar ataxia, peripheral neuropathy, and cognitive impairment. Chronic and excessive alcohol consumption is the primary cause of peripheral neuropathy. It is worth noting that peripheral neuropathy has no reliable treatment due to the poor understanding of its pathology.

Recent Findings

Coasting is a major feature of alcoholic neuropathy, largely due to chronic alcohol abuse. Its major features are hyperalgesia, allodynia, and burning pain. Even though much research was done in this area, still we do not have a full understanding of the mechanism of alcoholic neuropathy. However, some theories have been proposed. These include direct or indirect effects of alcohol metabolites, impaired axonal transport, suppressed excitatory nerve pathway activity, or imbalance in neurotransmitters. Activation of spinal cord microglia, mGlu5 spinal cord receptors, and hypothalamic-pituitary-adrenal axis also seem to be implicated in the pathophysiology of this alcoholic neuropathy. The goal of treatment is to impede further damage to the peripheral nerves while also restoring their normal physiology. Alcohol abstinence, intake of balanced diets, and treatment with medications are suggested including benfotiamine, alpha-lipoic acid, acetyl-l-carnitine, vitamin E, methylcobalamin, myo-inositol,N-acetylcysteine, capsaicin, tricyclic antidepressants, or antiepileptic drugs.

This review focuses on the many pathways that play a role in the onset and development of alcohol-induced neuropathy, as well as present the possible treatment strategies of this disorder, providing insights into a further search of new treatment modalities.
Immunomodulatory Therapies for COVID-19 in Solid Organ Transplant Recipients
Authors: Fernández-Ruiz Mario , Aguado José María
Published: October 2020

Purpose of Review

Severe coronavirus disease 2019 (COVID-19) is characterized by the development of a deleterious hyperinflammatory response, in which the pleiotropic cytokine interleukin (IL)-6 plays a pivotal role. The administration of immunomodulatory therapies has been proposed to revert the tissue damage induced by COVID-19-related cytokine release syndrome (CRS). The present review summarizes the biological rationale and available clinical experience with this therapeutic strategy in the specific scenario solid organ transplantation (SOT).

Recent Findings

A number of case reports, case series, and non-controlled cohort studies have assessed the efficacy and safety of the anti-IL-6-receptor monoclonal tocilizumab in SOT (namely kidney transplantation) recipients with COVID-19 pneumonia and CRS. Although the heterogeneity in patient management and the lack of a control group limit the interpretation of these results, tocilizumab therapy appears to provide some clinical benefit in post-transplant COVID-19 and to be reasonably safe in terms of bacterial superinfection. A large randomized clinical trial (RCT) has shown survival benefit with adjuvant corticosteroids in non-transplant patients, but supporting evidence is scarce for SOT recipients and confounded by the variable adjustment of baseline immunosuppression. Anecdotal experiences have been reported with the use of the anti-IL-1 agent anakinra and the NLRP3 inflammasome inhibitor colchicine in this population.

Immunomodulation has emerged as a promising option for SOT recipients with COVID-19-related CRS, with available experience mainly restricted to the anti-IL-6 agent tocilizumab. However, the supporting evidence is scarce and of low quality. In the absence of RCT, observational studies including well-matched control groups should be designed in future.
Modeling on naturalization of inflow and outflow nutrients sources of Blue Nile River at the Lake Tana in Basaltic Plateau of Ethiopia
Authors: Asitatikie Asimamaw Nigusie , Nigussie Endalkachew Diress
Published: October 2020

Lake Tana is the largest natural reservoir in Ethiopia and the head water of Abbay basin. However, after building of an irrigation weir and further lying Tunnel to Tana Belles, Lake Tana maximum amplitude of water level canges from 2.18 to 3.56 m that differ substantially in 1.38 m from amplitude of natural water level fluctuation. Understanding the natural characteristics of the Lake is important to know its water balance and for sustainable development. But it is difficult to study the natural characteristics of the Lake and its water balance using the regulated water level and outflow data sets. Thus it is evident that the regulated water level and outflow data sets have to be first naturalized before they are used for any analysis and modeling. Lake level and outflow data that have been collected since 1976 were considered to assess the regulation effect and then for naturalization. Inflows to the Lake from the main tributaries have also been collected to find if there are any correlations with either the Lake Level and/or the outflow. Regression analyses were used to develop the naturalization models. The regression analyses of flows from Gilgel Abay and Gummar with Lake Level shows that there is a very good correlation between them in different seasons. Besides, same has also been observed between Lake Level and out flow. These relationships can be used to naturalize the regulated outflow and water level.
Influence of growth kinetics on graphene domains shape under atmospheric pressure chemical vapor deposition
Authors: Fabiane Mopeli Samuel , Madito Moshawe Jack , Manyala Ncholu
Published: October 2020

In this work, the role of gas kinetics in the growth of lobed graphene domains by atmospheric pressure chemical vapor deposition (AP-CVD) is elucidated by sandwiching Cu foil between Si/SiO2 wafers. Two different growths were carried out: (1) A Cu foil was placed at the center of a quartz tube in AP-CVD for graphene growth and (2) another Cu foil was sandwiched between Si/SiO2 wafers to alter the nucleation growth kinetics of graphene domains to mimic those in low-pressure chemical vapor deposition (LP-CVD). From the scanning electron microscopy (SEM) images, the graphene domains of the sandwiched Cu foil displayed mostly four-lobed, parallel-sided domains which are usually obtained under LP-CVD as compared to Cu foil without sandwiching which showed typical hexagonal graphene domains of AP-CVD. The Raman spectroscopy confirmed that the domains are single-layer graphene. An electron backscatter diffraction (EBSD) showed that the Cu foil is predominantly (001). The results of this study agree with the theoretical predictions of growth kinetics in graphene synthesis by CVD and showed that it is possible to obtain single-layer graphene domains which are usually obtained under LP-CVD by restricting the gas flux through the boundary layer.

Graphic abstract
Trustworthy COVID-19 Mapping: Geo-spatial Data Literacy Aspects of Choropleth Maps
Authors: Juergens Carsten
Published: October 2020

Since the COVID-19 (coronavirus disease 2019) pandemic is a global phenomenon, many scientists and research organizations create thematic maps to visualize and understand the spatial spread of the disease and to inform mankind. Nowadays, Geographic Information Systems (GIS) and web mapping technologies enable people to create digital maps on demand. This fosters the permanent update of COVID-19 map products, even by non-cartographers, and their publication in news, media and scientific publications. With the ease and speed of map-making, many map creators seem to forget about the fundamental principles of good and easy-to-read thematic choropleth maps, which requires geo-spatial data literacy. Geo-spatial data literacy is an important skill, to be able to judge the reliability of spatial data, and to create ingenuous thematic maps. This contribution intends to make people of disciplines other than those that are map-related aware of the power of thematic maps and how one can create trustworthy thematic maps instead of misleading thematic maps which could, in a worst case,  lead to misinterpretation.
Gain Selection for Attitude Stabilization of Earth-Pointing Spacecraft Using Magnetorquers
Authors: Celani Fabio
Published: October 2020

This paper considers a feedback control law that achieves attitude stabilization for Earth-pointing spacecraft using only magnetorquers as torque actuators. The control law is proportional derivative (PD)-like with matrix gains, and it guarantees asymptotic stability. The PD matrix gains are determined through the numerical solution of a periodic linear quadric regulator problem. A case study shows the effectiveness of the considered control law, and specifically of the gain selection method, in a simplified simulation scenario.
Brahms's A German Requiem
Authors: Lott R. Allen
Published: October 2020

Examines in detail the contexts of Brahms's masterpiece and demonstrates that-contrary to recent consensus-it was performed and received as an inherently Christian work during the composer's life.
Houses and Society in Norwich, 1350–1660
Authors: King Chris
Published: October 2020

First full archaeological study of the urban environment of Norwich when its power was at its height.
Estimation of aerodynamic parameters near stall using maximum likelihood and extreme learning machine-based methods
Authors: Verma H.O. , Peyada N.K.
Published: October 2020

The stability and control derivatives are essential parameters in the flight operation of aircraft, and their determination is a routine task using classical parameter estimation methods based on maximum likelihood and least-squares principles. At high angle-of-attack, the unsteady aerodynamics may pose difficulty in aerodynamic structure determination, hence data-driven methods based on artificial neural networks could be an alternative choice for building models to characterise the behaviour of the system based on the measured motion and control variables. This research paper investigates the feasibility of using a recurrent neural model based on an extreme learning machine network in the modelling of the aircraft dynamics in a restricted sense for identification of the aerodynamic parameters. The recurrent extreme learning machine network is combined with the Gauss–Newton method to optimise the unknowns of the postulated aerodynamic model. The efficacy of the proposed estimation algorithm is studied using real flight data from a quasi-steady stall manoeuvre. Furthermore, the estimates are validated against the parameters estimated using the maximum likelihood method. The standard deviations of the estimates demonstrate the effectiveness of the proposed algorithm. Finally, the quantities regenerated using the estimates present good agreement with their corresponding measured values, confirming that a qualitative estimation can be obtained using the proposed estimation algorithm.
The Monetary Gold Principle: Back to Basics
Authors: Mollengarden Zachary , Zamir Noam
Published: October 2020

In The Case of the Monetary Gold Removed from Rome in 1943, the International Court of Justice concluded that it cannot decide a dispute in which a third party's legal interests “would form the very subject-matter of the decision.” This Article argues that what has become known as the Monetary Gold principle conflicts with the Court's obligation to decide cases submitted by consenting parties and should be abandoned.
Adapting a Federal Disaster Medical Assistance Team to Operate During a Pandemic
Authors: Garrett Andrew L.
Published: October 2020

After Hurricane Laura struck the southeast coast of Louisiana in August 2020, the National Disaster Medical System (NDMS), a component of the US Department of Health and Human Services, Office of the Assistant Secretary for Preparedness and Response, deployed several 35-person disaster medical assistance teams in response to requests for medical support at 3 hospital locations that had been severely damaged in the storm. This was the first natural disaster medical deployment for NDMS during the coronavirus disease (COVID-19) pandemic. This article describes the modifications to the standard operating procedures that were made at 1 site to reduce the risk of infection to our patients and NDMS responders, including changes to the physical layout of the tenting, and alterations to the triage and treatment process.
Greater autism knowledge and contact with autistic people are independently associated with favourable attitudes towards autistic people
Authors: Shand Alanna J. , Close Scarlett A. D. , Shah Punit
Published: October 2020

Understanding individual differences in attitudes to autism is crucial for improving attitudes and reducing stigma towards autistic people, yet there is limited and inconsistent research on this topic. This is compounded by a lack of appropriate measures and multivariate analyses. Addressing these issues, using up-to-date measures and multiple linear regression, we examined the relative contributions of participant age, sex, autism knowledge, level of contact with autistic people, and autistic traits to attitudes towards autistic people. We found that greater autism knowledge and higher levels of contact, but no other variables, were uniquely predictive of attitudes towards autistic people. We conclude that, in addition to public awareness campaigns to raise knowledge of autism, it may be important to increase contact between autistic and non-autistic people to improve public attitudes towards autistic people.
ERRATUM: CONTINUITY OF HILBERT–KUNZ MULTIPLICITY AND F-SIGNATURE
Authors: POLSTRA THOMAS , SMIRNOV ILYA
Published: October 2020

Unfortunately, there is a mistake in [PS, Lemma 3.10] which invalidates [PS, Theorem 3.12]. We show that the theorem still holds if the ring is assumed to be Gorenstein.
A 3000-year record of vegetation changes and fire at a high-elevation wetland on Kilimanjaro, Tanzania
Authors: Courtney Mustaphi Colin J. , Kinyanjui Rahab , Shoemaker Anna , Mumbi Cassian , Muiruri Veronica , Marchant Laura , Rucina Stephen M. , Marchant Rob
Published: October 2020

Kilimanjaro is experiencing the consequences of climate change and multiple land-use pressures. Few paleoenvironmental and archeological records exist to examine historical patterns of late Holocene ecosystem changes on Kilimanjaro. Here we present pollen, phytolith, and charcoal (>125 μm) data from a palustrine sediment core that provide a 3000-year radiocarbon-dated record collected from a wetland near the headwaters of the Maua watershed in the alpine and ericaceous vegetation zones. From 3000 to 800 cal yr BP, the pollen, phytolith, and charcoal records show subtle variability in ericaceous and montane forest assemblages with apparent multicentennial secular variability and a long-term pattern of increasing Poaceae and charcoal. From 800 to 600 cal yr BP, montane forest taxa varied rapidly, Cyperaceae abundances increased, and charcoal remained distinctly low. From 600 yr cal BP to the present, woody taxa decreased, and ericaceous taxa and Poaceae dominated, with a conspicuously increased charcoal influx. Uphill wetland ecosystems are crucial for ecological and socioeconomic resilience on and surrounding the mountain. The results were synthesized with the existing paleoenvironmental and archaeological data to explore the high spatiotemporal complexity of Kilimanjaro and to understand historical human-environment interactions. These paleoenvironmental records create a long-term context for current climate, biodiversity, and land-use changes on and around Kilimanjaro.
The comparison of standard and fully recursive multivariate models for genetic evaluation of growth traits in Markhoz goat: predictive ability of models and ranking of animals
Authors: Razmkabir Mohammad , Mokhtari Morteza , Mahmoudi Peyman , Rashidi Amir
Published: October 2020

Data of 2780 Markhoz kids originated from 1216 dams and 211 sires during 1993–2016 in Markhoz Goat Breeding Station, located in Sanandaj, Iran, were used. Traits investigated were body weights at birth, weaning, six-month age [six months weight (6MW)], nine-month age and yearling age [yearling weight (YW)]. Two considered multivariate models including standard multivariate model (SMM) and fully recursive multivariate model (FRM) were compared using deviance information criterion (DIC) and predictive ability measures including mean square of error (MSE) and Pearson's correlation coefficient between the observed and predicted values $(r(y,\hat{y}))$ of records. Spearman's rank correlation coefficients between posterior means of direct genetic effects of the studied traits of kids under SMM and FRM were also calculated across all, 50, 10 and 1% top-ranked animals. In general, FRM performed better than SMM in terms of lower DIC and MSE and also higher $r\lpar y\comma \;\hat{y}\rpar$. For all traits, the lowest MSE and the highest $r\lpar y\comma \;\hat{y}\rpar$ were obtained under FRM. All structural coefficients estimated under FRM were statistically significant except for that of 6MW on YW. Comparisons of Spearman's rank correlations between posterior means of direct genetic effects of kids for growth traits under SMM and FRM revealed that taking the causal relationships among the studied growth traits of Markhoz goat into account may cause considerable re-ranking for the animals in terms of estimated breeding values, especially for the top-ranked animals. It may be concluded that FRM had more plausibility over SMM for genetic evaluation of the studied growth traits in Markhoz goat.
A new molecular nomenclature for Taenia hydatigena: mitochondrial DNA sequences reveal sufficient diversity suggesting the assignment of major haplotype divisions
Authors: Ohiolei John Asekhaen , Yan Hong-Bin , Li Li , Li Wen-Hui , Wu Yao-Dong , Alvi Mughees Aizaz , Zhang Nian-Zhang , Fu Bao-Quan , Wang Xue-Lin , Jia Wan-Zhong
Published: October 2020

Cysticercosis caused by the metacestode larval stage of Taenia hydatigena formerly referred to as Cysticercus tenuicollis is a disease of veterinary importance that constitutes a significant threat to livestock production worldwide, especially in endemic regions due to condemnation of visceral organs and mortality rate of infected young animals. While the genetic diversity among parasites is found to be potentially useful in many areas of research including molecular diagnostics, epidemiology and control, that of T. hydatigena across the globe remains poorly understood. In this study, analysis of the mitochondrial DNA (mtDNA) of adult worms and larval stages of T. hydatigena isolated from dogs, sheep and a wild boar in China showed that the population structure consists of two major haplogroups with very high nucleotide substitutions involving synonymous and non-synonymous changes. Compared with other cestodes such as Echinococcus spp., the genetic variation observed between the haplogroups is sufficient for the assignment of major haplotype or genotype division as both groups showed a total of 166 point-mutation differences between the 12 mitochondrial protein-coding gene sequences. Preliminary analysis of a nuclear protein-coding gene (pepck) did not reveal any peculiar changes between both groups which suggests that these variants may only differ in their mitochondrial makeup.
Disentangling the beta-diversity in anuran parasite communities
Authors: D'Bastiani Elvira , Campião Karla M.
Published: October 2020

There is great heterogeneity in parasite communities among hosts, understanding the nature and drivers of such variations is still a great scientific quest. Here, we analyse the variation in parasite communities by addressing the following questions: (i) What is the beta-diversity component (nestedness or turnover) that most contributes to beta diversity in parasite communities among anuran species? (ii) Does the beta diversity of parasite communities follow a non-random pattern? (iii) Is the dissimilarity in composition of parasite communities related to the phylogenetic or functional dissimilarity among hosts? We found that turnover in parasite assemblages was the main component of beta diversity, but the variation observed both in the total beta diversity and in its components did not differ from the respective null models. The dissimilarity among parasite communities was not related to the phylogenetic species variability or functional dissimilarity among anuran species for most localities. In short, our findings may indicate a process of resource tracking by the parasite species, in which the resource may not necessarily be conserved phylogenetically in their hosts.
Shovelling snow in Finnish Lapland: Social and aesthetic perspectives on an everyday activity
Authors: Strauss-Mazzullo Hannah
Published: October 2020

For residents of Finnish Lapland, snow frames outdoor and indoor activities during the entire year, both in its presence and in its absence. This article focuses on people’s social and aesthetic perspectives on what is commonly referred to as “snow work”, lumityö. In ethnographic tradition, the aim is to understand “doing living with snow” in contemporary urban society – with snow that falls and, unlike other forms of precipitation, stays around for many months to come, thus creating physical, mouldable obstacles that have mental, social and environmental consequences. The shovelling of snow is considered an important physical activity that allows people to practice their individual expert knowledge and lets them socialise during long annual periods of potential isolation. Hence, apart from its restricting features, snow and ice enhance the meaning of homeowners’ dwelling in the open. In this context, aesthetic and creative concepts are essential where they draw on people’s gardening and artistic skills, and bring satisfaction to those engaging with this mundane and unavoidable activity.
Chronological quarantine and ageism: COVID-19 and gerontology's relationship with age categorisation
Authors: Fletcher James Rupert
Published: October 2020

In March 2020, the government of the United Kingdom advised all people aged 70 and above to self-isolate stringently for a minimum of 12 weeks in response to COVID-19. The British Society of Gerontology criticised the government for ignoring individual differences, deeming the approach ageist. Former British Geriatrics Society president David Oliver contested accusations of ageism, arguing that the approach was pragmatic discrimination based on epidemiological evidence. This debate catalyses core gerontological tensions regarding ageism, discrimination, categorisation and heterogeneity. A critical realist perspective reveals that both the government and gerontology are struggling to negotiate these irresolvable tensions. Contrary to the binary debate, age-based isolation simultaneously represents pragmatic discrimination and value-driven ageism. However, it does so partly because it relies on a chronologic epistemology that positions age as a potent biosocial axis of meaningful difference, thereby reflecting gerontology's own ageism. The ethical purism of gerontological accusations of ageism is thus somewhat misplaced, potentially obscuring an opportunity for reflection on value-laden engagements with age in social research.
Word learning in monolingual and bilingual children: The influence of speaker eye-gaze
Authors: Gangopadhyay Ishanti , Kaushanskaya Margarita
Published: October 2020

The current study examined the impact of a speaker's gaze on novel-word learning in 4-5-year old monolingual (N = 23) and bilingual children (N = 24). Children were taught novel words when the speaker looked at the object both times while labeling it (consistent) and when the speaker looked at the object only the first time (inconsistent). During teaching, bilingual children differentiated between the target object (that matched the label) and non-target object (that did not match the label) earlier than the monolingual children on trials without eye-gaze information. However, during testing, monolingual children showed more robust retention of novel words than bilingual children in both conditions. Findings suggest that bilingualism shapes children's attention to eye-gaze during word learning, but that, ultimately, there is no bilingual advantage for utilizing this cue in the service of word retention.
Magnetic Properties of Ferritchromite and Cr‐Magnetite and Monitoring of Cr‐Spinels Alteration in Ultramafic and Mafic Rocks
Authors: Hodel F. , Macouin M. , Trindade R. I. F. , Araujo J. F. D. F. , Respaud M. , Meunier J. F. , Cassayre L. , Rousse S. , Drigo L. , Schorne‐Pinto J.
Published: October 2020

Spinel is a ubiquitous mineral in mafic/ultramafic rocks. Spinel cores chemistry is extensively used as a petrogenetic proxy while their alteration phases, ferritchromite, and Cr‐magnetite, are used as metamorphic grade indicators. However, the magnetic properties and composition of these phases are still ill‐defined and no consensus exists concerning the metamorphic conditions involved in their formation. Here, we use the magnetic properties of these Cr‐spinel alteration phases, via field‐dependent parameters and observations with a magnetic microscope coupled with mineral chemistry and Mössbauer spectroscopy, to better constrain their composition. We identify Cr‐magnetite by a Curie point of ca. 520°C. We show that it is characterized by an n between 0.1 and 0.2 in the Fe‐Cr spinel formula [Fe2+(Fe1−nCrn)2O4], which corresponds to 6–13 wt.% of Cr2O3. The abundance of Cr‐magnetite indicates a strong alteration of Cr‐spinels that could reflect a significant hydrothermal activity rather than a high metamorphism grade. Normalized variation curves of the magnetic susceptibility during heating allow a relative quantification of the contributions of different magnetic phases to the magnetic susceptibility. This highlights a link between ferritchromite destabilization into maghemite at ca. 130°C followed by the destabilization of this maghemite starting at 300°C. We identify specific covariation trends between these two magnetic species characterizing different alteration processes. This study opens the door to magnetic monitoring of the Cr‐spinel alteration state in mafic and ultramafic rocks. It constitutes a new, fast, and weakly destructive way to study the petrological history of both terrestrial and extraterrestrial rocks.
Geodetic Source Modeling of the 2019 Mw 6.3 Durrës, Albania, Earthquake: Partial Rupture of a Blind Reverse Fault
Authors: Govorčin M. , Wdowinski S. , Matoš B. , Funning G. J.
Published: October 2020

We address geometric and kinematic properties of the Mw 6.3 26 November 2019 Durrës earthquake, the strongest earthquake in Albania in the past 40 years. Using coseismic surface displacements from Sentinel‐1 Differential Interferometric Synthetic Aperture Radar (DInSAR) and nearby Global Navigational Satellite System (GNSS) stations, we invert for the geometry and slip of the causative fault. We find that both a steep SW‐dipping fault (dip 71°) and a shallow NE‐dipping fault (dip 15°) can fit the data equally well. However, the slip on the SW‐dipping fault occurs at depths 11–23 km, similar to the depths of the mainshock and aftershock seismicity, and thus, we prefer that model. The location of our preferred fault plane correlates with the mapped SW‐dipping backthrust, the Vore fault. The fault rupture did not reach the surface, which implies that an updip stress propagation onto the unruptured shallow portion of the Vore fault and its secondary structures pose an increased seismic hazard for cities in Albania, including the capital, Tirana.