bluuebunny/crossref_metadata_2025 huggingface dataset:
Use of imaging-based dosimetry for personalising radiopharmaceutical therapy of cancer
Authors: Beauregard Jean-Mathieu
Published: December 2022

Theranostics – i.e., the combination of molecular imaging and radiopharmaceutical therapy of cancer targeting a common biological feature – is a rapidly expanding field owing the recent successes of novel radiopharmaceutical therapies, such as 177Lu-based prostate-specific membrane antigen radioligand therapy of prostate cancer and peptide receptor radionuclide therapy of neuroendocrine tumours. Despite the ongoing technical developments in imaging-based dosimetry, the existence of tumour absorbed dose-efficacy and organ absorbed dose-toxicity relationships, as well as the high interpatient variability in absorbed doses per unit activity, radiopharmaceutical therapies are still mostly administered in a fixed-activity, one-size-fits-all fashion. This is at odds with the principles of radiation oncology, where the absorbed doses to tissues are prescribed and their delivery is carefully planned and controlled for each individual patient to maximise the clinical benefits. There is a growing body of clinical evidence that dosimetry-based radiopharmaceutical therapy allows to safely optimise tumour irradiation, which translates into improved clinical outcomes. In this narrative review, we will present the reported prospective clinical experience to date on the use of imaging-based dosimetry to personalise radiopharmaceutical therapies.
Series admittance–impedance controller for more robust and stable extension of force control
Authors: Fujiki Takuto , Tahara Kenji
Published: December 2022

To control a robot performing cooperative work between a human and robot, not only the position but also the force must be controlled from the viewpoint of human–robot contact. In addition, when a robot is used for fitting and handling, tasks that are conventionally performed by experienced humans, controlling the grasping force and the force exerted by the joints can produce motions similar to those of humans and contribute to improving the success rate of the work. In the field of force control, in addition to direct force control, admittance control and impedance control are modes based on the relationship between position and force, which are known to be robust and safe. However, admittance control often becomes unstable when the robot comes into contact with a rigid body, and the performance of impedance control is degraded by friction. In this study, we aim to realize safe and accurate force control in cooperative work with humans. As a precursor, we propose admittance and impedance control, which is a series connection of conventional admittance control and impedance control. We show that the proposed force control is more robust, stable, and accurate than impedance control and admittance controls alone, or at least as good as them, when in contact with an unknown environment. Its basic effectiveness and practical usefulness are demonstrated through numerical simulations and experimental results.
Potentially inappropriate medication use in the elderly: physicians’ and hospital pharmacists knowledge, practice, confidence, and barriers
Authors: Akande-Sholabi Wuraola , Fafemi Adeola
Published: December 2022

Background

Inappropriate medication prescribing and dispensing by physicians and pharmacists is a preventable cause of morbidity and mortality in the elderly. Signifying the importance of healthcare professionals’ knowledge of potentially inappropriate prescribing tools/ guidelines which would improve overall health outcomes. Beers Criteria is one of the most used guidelines that list specific potentially inappropriate medications (PIMs). This study aimed to investigate physicians’ and hospital pharmacists’ awareness, knowledge, practice, confidence, and barriers to the use of Beers criteria.

Methods

A cross-sectional survey was carried out among 66 hospital pharmacists and 31 family medicine physicians working in a teaching hospital in Nigeria, between May and September 2021 using a self-administered questionnaire. Knowledge of PIMs was assessed using 11 clinical vignettes based on the 2019 Beers Criteria. Practice behavior towards elderly patients was assessed using a 5-item statement with a 5-point Likert scale. Perceived barriers to the appropriate use of Beers Criteria were assessed using a 15-item statement. Descriptive and inferential statistics were used to analyze the data.

Results

A total of 66 hospital pharmacists and 31 family medicine physicians participated in the study. Only (24; 36.4%) pharmacists and (4; 12.9%) physicians knew guidelines that listed specific PIMs. In all (21; 31.8%) pharmacists and (11; 35.4%) physicians demonstrated good knowledge of Beers Criteria, while most pharmacists (55; 83.3%) and physicians (29; 93.5%) reported good practice when dealing with elderly patients in terms of asking relevant questions and considering their ages while dispensing medications. Knowledge scores were not significantly associated with hospital pharmacists’ socio-demographics. Most of the physicians and pharmacists were confident in the care provided for geriatric patients. The majority (66; 100.0%) pharmacists and (28; 93.5%) physicians suggested training through seminar presentations as a measure to improve the use of Beers’ criteria. Lack of time to counsel patients was a major barrier recounted by both physicians and pharmacists.

Conclusion

Healthcare professionals that participated in this study had satisfactory practice, although a gap in the knowledge of hospital pharmacists and family medicine physicians was noted. In addition to creating awareness among healthcare professionals and training on PIMs and Beers’ criteria, a multidisciplinary approach to reduce potentially inappropriate prescribing and dispensing would greatly help reduce the incidence of potentially inappropriate medication use among elderly patients.
Mindfulness training for community-based psychotherapists: a feasibility study
Authors: Sucich James T. , Lehrer Jeremy , Breitbart Vicki , Julliard Kell N.
Published: December 2022

Background

While mindfulness training’s feasibility has been assessed in many health care settings, the feasibility of teaching mindfulness to psychotherapists of various orientations for both self- and patient-care has not been explored. The objectives of this feasibility assessment were to determine the degree to which clinic psychotherapists were willing to complete a skills-based mindfulness training program; evaluate the acceptability of integrating mindfulness interventions into an urban community mental health clinic; examine the training’s influence on both personal mindfulness practice and integration into patient care; and explore the impact of a support group following the training.

Methods

Data on six aspects of feasibility were gathered through quantitative surveys, semi-structured qualitative interviews, and group observation and feedback, analyzed using grounded theory.

Results

Sixteen therapists and one administrator attended at least one session of this voluntary program and responded to the associated surveys. At 1-year post-training, 7 participants had attended one or more group support sessions, and 4 more than 50% of sessions. The following factors were identified as contributing to the training’s success: significant interest on the part of clinic staff to receive the training; diversity of the teaching staff, buy-in from clinic administration, provision of meditation scripts, role-play exercises, the variety of practices taught, and case presentations. Therapists indicated that the training helped them create a personal mindfulness practice, and several proceeded to integrate mindfulness into client sessions. A bi-weekly support group organized after the training encompassed group practice, discussion, case presentations, and information about trauma-sensitive mindfulness. Clinicians identified the following challenges to integrating mindfulness into sessions: lack of scripts in client languages other than English, the unacceptability of mindfulness to some clients’ religious beliefs, the lack of appropriateness for clients facing ongoing psychosocial crises, the lack of interest on the part of some clients, and the time constraints posed by brief therapy sessions.

Conclusions

These findings indicate that such training may be feasible in community mental health settings given support from leadership and the presence of qualified facilitators within the organization. Adaptations to the training based on participant feedback can inform a larger scale trial that compares our protocol with another intervention in the treatment of a psychological disorder or condition identified by the participants as having responded favorably to the program.
Feasibility of testing the effectiveness of a theory-informed intervention to reduce imaging for low back pain: a pilot cluster randomised controlled trial
Authors: Jenkins Hazel J. , French Simon D. , Young Anika , Moloney Niamh A. , Maher Chris G. , Magnussen John S. , Dear Blake F. , Hancock Mark J.
Published: December 2022

Background

General medical practitioner (GP) recruitment and subsequent data collection in clinical practice are challenging and may limit successful completion of a large-scale trial. The aim of this study was to assess the feasibility of undertaking a cluster randomised controlled trial to test an intervention to reduce non-indicated imaging for low back pain in general medical practice.

Methods

A pilot cluster randomised controlled trial was performed, with recruitment of GPs and randomisation of GP clinics. All GPs attended a training session and were asked to record low back pain codes in electronic medical records for any low back pain presentations. Intervention group GPs were trained in the use of a patient education booklet to be used during low back pain patient visits. Control group GPs provided usual care. Outcomes for the proposed trial were collected to determine feasibility. GP recruitment was assessed as the proportion of GPs approached who consented to participate. Low back pain imaging outcomes were collected from electronic medical records (counts of patients presenting with low back pain) and from Australian healthcare administrative (Medicare) data (counts of imaging use). GP compliance with study procedures was assessed and qualitative data reported.

Results

Thirty-four GP clinics were approached, with four participating (12%). At these clinics, 13/19 (68%) GPs consented to participate, and 10/19 (53%) started the study. Outcome data were collected from medical records for all GPs. Three GPs (30%) withdrew consent to access Medicare data, limiting reporting of imaging outcome measures. Three GPs (30%) self-reported low compliance entering low back pain codes.

Conclusions

This pilot cluster randomised controlled trial demonstrated the feasibility of many aspects of a full-scale effectiveness study, while also identifying a number of challenges that need to be resolved. Recommendations related to GP recruitment, study compliance, data collection, and outcome measures were made to increase the success of a future trial.

Trial registration

Australia and New Zealand Clinical Trials Register (ANZCTR), Trial ID: ACTRN12619000991112; Registered 11 July 2019, https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=376973
Reconstruction of mandibular defects in osteoradionecrosis and medication-related osteonecrosis of the jaw using fibula free flap and management of postoperative wound infections
Authors: Oh Hyemin , Kwon Dohyun , Ahn Jaemyung , Paeng Jun-Young
Published: December 2022

Background

Complications from osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ) include oro-cutaneous fistulas, necrotic bone exposure, soft-tissue defects, and pathologic fractures. The fibula free flap (FFF) is a common free flap method used to reconstruct the mandible in severe cases. Recently, we have used the FFF successfully for the reconstruction of ORN and MRONJ mandibular defects. We report this method as a recommended technique for the treatment of ORN and MRONJ and the management method of postoperative infections.

Methods

Four patients who were diagnosed with ORN of the mandible and 3 patients who were diagnosed with MRONJ of the mandible were included in the study. Among the 7 patients, 3 patients also had pathologic fractures. Partial mandibulectomy and FFF reconstruction were performed at the Department of Oral and Maxillofacial Surgery, Samsung Medical Center from April 2019 to March 2021.

Results

All 7 patients recovered following the reconstruction of the defect by FFF. Four patients experienced infections after surgery and pus cultures were performed. All were well healed without flap damage after changing the antibiotics by consultation with infectious medicine experts.

Conclusion

FFF is a widely used method and can provide an extensive flap to reconstruct the mandible, especially those affected by ORN or MRONJ. If an infection occurs after surgery, appropriate antibiotic changes should be made through cooperation with the infectious medicine department. Therefore, FFF is a well-established and recommended method even in cases of challenging reconstruction.
Guillain–Barré syndrome following different COVID-19 vaccines: a case series
Authors: Shalash Ali , Belal Nourhan , Zaki Amr S. , Georgy Shady S. , Doheim Mohamed Fahmy , Hazzou Ahmed , Abdelnasser Azza
Published: December 2022

Background

The COVID-19 vaccine-related Guillain–Barré syndrome (GBS) has been described for both messenger-RNA vaccine and adenovirus-vectored types in a few cases with great public concern and the necessity to inform physicians about the variations of its presentations given its life-threatening consequences.

Case presentation

This case series highlighted the presentation with GBS following different COVID-19 vaccinations in seven cases with ages ranging from 29 to 59 years. Three patients received the AstraZeneca vaccine, two received the Pfizer vaccine, one received Sinopharm, and one received the Janssen vaccine. Latency ranged from 5 to 60 days and cases achieved either partial or complete improvement after treatment trials. Patients responded to plasmaphereses, but not pulse steroid therapy.

Conclusion

This case series highlights the variable presentations and outcomes of GBS following different COVID-19 vaccination from one center. The early identification and appropriate management of such cases can lead to better outcomes.
Effect of gender difference on psychiatric outcomes for hepatitis C virus patients receiving direct-acting antivirals in Egyptian population: a cohort study
Authors: Mahran Zainab Gaber , Khalifa Hossam , Makhlouf Nahed A. , Mostafa Dina K. , Aboalam Hani Sayed , Moustafa Ehab F. , Ahmed Gellan K.
Published: December 2022

Background

Chronic liver disease is primarily caused by hepatitis C virus (HCV). HCV produces extrahepatic psychiatric problems. So, patients with CHC who received sofosbuvir-based direct-acting antiviral agents (DAAs) were evaluated for psychiatric manifestations, specifically depression and anxiety symptoms. Additionally, evaluate the impact of gender on psychiatric manifestations of sofosbuvir-based DAAs and identify their potential risk factors for psychiatric manifestations. In this prospective study, 170 CHC patients without prior treatment received DAA therapy who categorized into 2 groups, group 1 comprised male participants (Nb = 97), and group two comprised female participants (Nb = 73). All participants were evaluated with the five-factor model of personality (SIFFM), Hamilton Depression Rating Scale (HDS), and Hamilton Anxiety Rating Scale (HAS) at baseline and repeated follow up until 3 months after treatment end.

Results

Our findings indicated that, a progressive decline in the mean HADS-A and HADS-D scores between baseline (before treatment) and consequence follow-up (during and after treatment) measurements without significant difference regarding gender. No statistically significant difference between the groups regarding the mean values of SIFFM. High levels of extraversion were more likely to increase depression levels.

Conclusions

DAA treatment significantly improved anxiety and depression symptoms in CHC patients. Gender did not affect sofosbuvir-based DAA psychiatric symptoms. High extraversion increased depression risk.
Microbiological characteristics of bread dough and nutritional quality of “Tabnen-naow,” ethnic artisan bread in Burkina Faso
Authors: Tapsoba François , Ouédraogo Nicolas , Kagambèga Boureima , Ouédraogo Ali , Zongo Oumarou , Nikièma Fulbert , Savadogo Aly
Published: December 2022

This study aimed to evaluate the microbiological characteristics of bread dough and the nutritional quality of “Tabnen-naow,” an ethnic artisan bread consumed mainly in Burkina Faso. Originating in Boussé, this bread is spreading to the outskirts of Ouagadougou for several reasons, such as the increase in the price of industrial bread and especially the supposed low glycemic index of artisan bread. However, there is insufficient information in the literature about the nutritional quality and technology of artisan bread in Burkina Faso. For this purpose, surveys were conducted among artisan bakers in five artisan bread production units in Ouagadougou, using survey forms to draw the production diagram. The microbiological characteristics of bread dough were evaluated using standard microbiology methods. Lastly, the nutritional quality of ethnic artisan bread was determined using standard techniques. All the bakers were male, between 22 and 34 years old, with an average age of 27.8 ± 5.1 years. They all used wheat flour, mainly (80%) from the Grand Moulin du Faso (GMF). The Baker’s dough fermentation was done at room temperature using dry or lyophilized yeast. The interesting microorganisms (yeasts, lactic acid bacteria) were present in all the bread dough samples. The yeast (2.5 108 CFU/g) and lactic acid bacteria (2.27 107 CFU/g) were abundant apart from the one bread dough, which had a low lactic acid bacterial load. The ethnic artisan bread contains carbohydrates (88.20–89.05%), proteins (9.60–10.60%), and minerals such as iron (11.56 to 89.27 mg/kg), calcium (00.00–290.03 mg/kg), and zinc (69.18 ± 36.74 to 389.10 ± 32.89 mg/kg). The nutritional composition revealed that ethnic artisan bread could contribute significantly to a healthy diet and food security.
Evaluation of seasonal catchment dynamic storage components using an analytical streamflow duration curve model
Authors: Huang Chia-Chi , Yeh Hsin-Fu
Published: December 2022

Dynamic storage refers to groundwater storage that is sensitive to rainfall infiltration, streamflow generation, evapotranspiration, and other variables involving groundwater gain or loss. It plays a crucial role in habitat maintenance and the mitigation of environmental impacts on regional hydrological behaviors. Dynamic storage can be separated into direct storage, which contributes to the river channel, and indirect storage, which is insensitive to streamflow. The combination of diverse approaches would provide an estimation of the two storage types. This study estimated optimal baseflow coefficients and direct storage in the wet and dry seasons using an analytical streamflow duration curve model in eight catchments of the Choushui River Basin from 2013 to 2017. The water balance approach was then combined to assess indirect storage for evaluating seasonal dynamic storage components. The model applicability for each catchment of the Choushui River Basin in the wet and dry seasons was assessed using the similarity between observed and simulated flow duration curves, namely Kolmogorov–Smirnov distance. We also applied it to assess the performance difference between model and streamflow recession analysis, which is typically used to estimate baseflow coefficients. The results demonstrated that seasonal differences in baseflow coefficients were related to catchment characteristics as well as the aquifer extent through which groundwater flows. The model utilizing maximum likelihood estimation exhibited superior performance than streamflow recession analysis and was highly applicable in our study area in wet and dry seasons. Dynamic storage components demonstrated a considerable difference in the additional groundwater storage between dry and wet seasons and a loss of direct storage was observed in most catchments during the dry season.
Plant bioactive compounds and their mechanistic approaches in the treatment of diabetes: a review
Authors: Anshika  , Pandey Rupesh Kumar , Singh Lubhan , Kumar Sokindra , Singh Prabhat , Pathak Manish , Jain Shruti
Published: December 2022

Background

Diabetes mellitus (DM) is a growing disease across the world; diabetes is a complex metabolic disorder in which blood glucose concentration level increases and continue for a prolonged period due to a decrease secretion of insulin or action, resulting in the disorder of carbohydrate, lipid, and protein metabolism. The plant-related bioactive compounds have proven their efficacy with least toxicities and can be utilized for the disease treatment. Our objective is to elucidate the mechanism of action of plant bioactive compounds which can give future direction in diabetes treatment.

Main body

In this review paper, we briefly study more than 200 research papers related to disease and bioactive compounds that have therapeutic applicability in treatment. The plant contains many bio-active compounds which possess in vitro and in vivo anti-diabetic effect which may be responsible for the hypoglycaemic property by inhibiting the digestive enzyme i.e. alpha-amylase and alpha-glucosidase, by producing mimetic action of insulin, by reducing the oxidative stress, by showing antihyperglycemic activity and hypolipidemic activity, by inhibition of aldose reductase, and by increasing or enhancing glucose uptake and insulin secretion.

Conclusion

Our study revealed that terpenes, tannin, flavonoids, saponin, and alkaloids are important bioactive constituents for anti-diabetic activity. The mechanistic approach on alpha-glucosidase and alpha-amylase, hypolipidemic activity, and AR inhibitory action clear-cut explain the therapeutic applicability of these bioactive compounds in disease. Plants that contain these bioactive compounds can be good drug candidates for future research on diabetes treatment.
Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study
Authors: Du Yang , Zhu Ya-Juan , Zhou Yi-Xin , Ding Jing , Liu Ji-Yan
Published: December 2022

Metformin, a biguanide drug, is the most commonly used first-line medication for type 2 diabetes mellites due to its outstanding glucose-lowering ability. After oral administration of 1 g, metformin peaked plasma concentration of approximately 20–30 μM in 3 h, and then it mainly accumulated in the gastrointestinal tract, liver and kidney. Substantial studies have indicated that metformin exerts its beneficial or deleterious effect by multiple mechanisms, apart from AMPK-dependent mechanism, also including several AMPK-independent mechanisms, such as restoring of redox balance, affecting mitochondrial function, modulating gut microbiome and regulating several other signals, such as FBP1, PP2A, FGF21, SIRT1 and mTOR. On the basis of these multiple mechanisms, researchers tried to repurpose this old drug and further explored the possible indications and adverse effects of metformin. Through investigating with clinical studies, researchers concluded that in addition to decreasing cardiovascular events and anti-obesity, metformin is also beneficial for neurodegenerative disease, polycystic ovary syndrome, aging, cancer and COVID-19, however, it also induces some adverse effects, such as gastrointestinal complaints, lactic acidosis, vitamin B12 deficiency, neurodegenerative disease and offspring impairment. Of note, the dose of metformin used in most studies is much higher than its clinically relevant dose, which may cast doubt on the actual effects of metformin on these disease in the clinic. This review summarizes these research developments on the mechanism of action and clinical evidence of metformin and discusses its therapeutic potential and clinical safety.
Catecholamines modulate the hypoxic ventilatory response of larval zebrafish (Danio rerio)
Authors: Kevin Pan Yihang , Julian Tess , Garvey Kayla , Perry Steve F.
Published: December 2022

The hypoxic ventilatory response (HVR) in fish is an important reflex that aids O2 uptake when low environmental O2 levels constrain diffusion. In developing zebrafish (Danio rerio), the acute HVR is multiphasic, consisting of a rapid increase in ventilation frequency (fV) during hypoxia onset, followed by a decline to a stable plateau phase above fV under normoxic conditions. In this study, we examined the potential role of catecholamines in contributing to each of these phases of the dynamic HVR in zebrafish larvae. We showed that adrenaline elicits a dose-dependent β-adrenoreceptor (AR)-mediated increase in fV that does not require expression of β1-ARs, as the hyperventilatory response to β-AR stimulation was unaltered in adrb1−/− mutants, generated by CRISPR/Cas9 knockout. In response to hypoxia and propranolol co-treatment, the magnitude of the rapidly occurring peak increase in fV during hypoxia onset was attenuated (112±14 breaths min−1 without propranolol to 68±17 breaths min−1 with propranolol), whereas the increased fV during the stable phase of the HVR was prevented in both wild type and adrb1−/− mutants. Thus, β1-AR is not required for the HVR and other β-ARs, although not required for initiation of the HVR, are involved in setting the maximal increase in fV and in maintaining hyperventilation during continued hypoxia. This adrenergic modulation of the HVR may arise from centrally released catecholamines because adrenaline exposure failed to activate (based on intracellular Ca2+ levels) cranial nerves IX and X, which transmit O2 signals from the pharyngeal arch to the central nervous system.
Η ηγεσία και η σχέση της με το μοντέλο των πέντε παραγόντων
Authors: Δαμιανού Αικατέρινη
Published: December 2022

Η αυθεντική ηγεσία αποτελεί ένα μοντέλο ηγεσίας που προέκυψε ως απάντηση στην κρίση με την οποία ήρθε αντιμέτωπη η ηγεσία στις αρχές του αιώνα σε επίπεδο επιχειρηματικό, οικονομικό, αξιακό και ηθικό (Gardner, Avolio, Luthans, May & Walumbwa, 2005). Η αυθεντική ηγεσία αφορά την ευθυγράμμιση αξιών, λόγων και πράξεων του ηγέτη. Όταν αυτή η ευθυγράμμιση είναι αληθινή, γίνεται φανερή στην ομάδα και τους ακόλουθους του ηγέτη με ευεργετικά αποτελέσματα για τους στόχους του οργανισμού αλλά και την ευεξία των εργαζομένων (Begley, 2001). Ο αυθεντικός ηγέτης αποτελεί πρότυπο και φάρο έμπνευσης για τους εμπλεκόμενους στον οργανισμό και δημιουργεί τις συνθήκες για την επίτευξη των στόχων (Northouse, 2010).Η προσωπικότητα του ηγέτη αποτελεί μια σημαντική παράμετρο και ουσιαστική προϋπόθεση για την ανάπτυξη της ηγεσίας. Το μοντέλο των πέντε παραγόντων αποτελεί την πιο ολοκληρωμένη και διαδεδομένη ως τώρα προσέγγιση στην προσωπικότητα. Η αποτύπωση των χαρακτηριστικών της προσωπικότητας χρησιμεύει σε όλους τους τομείς που αφορούν την εργασία καθώς θεωρείται ότι επηρεάζει την ηγεσία ποικιλοτρόπως (Barrick & Mount, 1991).Η σχολική ηγεσία αποτελεί ίσως τον πιο κρίσιμο τομέα στην εκπαίδευση, καθώς επηρεάζει καταλυτικά όλους τους τομείς δραστηριότητας στο σχολείο, την κουλτούρα, την απόδοση και την ψυχολογική κατάσταση των εμπλεκόμενων αλλά και τα μαθησιακά αποτελέσματα (Bush & Glover, 2014). Στη χώρα μας είναι άγνωστο κατά πόσο οι διευθυντές σχολικών μονάδων πρωτοβάθμιας και δευτεροβάθμιας εκπαίδευσης ασκούν αυθεντική ηγεσία. Είναι επίσης άγνωστα τα χαρακτηριστικά της προσωπικότητάς τους και κατά πόσον αυτά σχετίζονται με την αυθεντική ηγεσία.Για να προσπελαστεί αυτό το ζήτημα, χρησιμοποιήθηκαν το ερωτηματολόγιο αυθεντικής ηγεσίας (ALQ) και το ερωτηματολόγιο των πέντε παραγόντων (BFI). Η παραγοντική ανάλυση κατέδειξε επαρκή αξιοπιστία και εγκυρότητα των εργαλείων. Τα αποτελέσματα έδειξαν ότι οι διευθυντές παρουσιάζουν υψηλές τιμές στον παράγοντα της ευσυνειδησίας, η οποία ακολουθείται από την συγκαταβατικότητα, τη δεκτικότητα στην εμπειρία και την εξωστρέφεια, ενώ παράλληλα ο νευρωτισμός έχει χαμηλές τιμές. Επίσης οι διευθυντές εμφανίζουν στοιχεία αυθεντικής ηγεσίας, με τον παράγοντα της εσωτερικευμένης ηθικής προοπτικής να προπορεύεται. Συνδυαστικά, η ευσυνειδησία φαίνεται να επηρεάζει τον παράγοντα της αυτογνωσίας αλλά και την αυθεντική ηγεσία συνολικά. Το φύλο, η ηλικία, η εμπειρία, το έτος αποφοίτησης από το πανεπιστήμιο, η επιμόρφωση και τα χρόνια προϋπηρεσίας επίσης επηρεάζουν την αυθεντική ηγεσία των διευθυντών.
The genome sequence of the high brown fritillary, Fabriciana adippe (Dennis & Schiffermüller, 1775)
Authors: Lohse Konrad , Vila Roger , Hayward Alex , Laetsch Dominik R ,   Wellcome Sanger Institute Tree of Life programme,   Wellcome Sanger Institute Scientific Operations: DNA Pipelines collective,   Tree of Life Core Informatics collective, Wahlberg Niklas ,   Darwin Tree of Life Consortium
Published: December 2022

We present a genome assembly from an individual female Fabriciana adippe (the high brown fritillary; Arthropoda; Insecta; Lepidoptera; Nymphalidae). The genome sequence is 485 megabases in span. Most of the assembly (99.98%) is scaffolded into 29 chromosomal pseudomolecules with the Z sex chromosome assembled. The complete mitochondrial genome was also assembled and is 15.1 kilobases in length. Gene annotation of this assembly in Ensembl identified 13,536 protein coding genes.
The genome sequence of the common mini-mining bee Andrena minutula (Kirby, 1802)
Authors: Falk Steven ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life programme,   Wellcome Sanger Institute Scientific Operations: DNA Pipelines collective,   Tree of Life Core Informatics collective, Blomfield-Smith Hermione ,   Darwin Tree of Life Consortium
Published: December 2022

We present a genome assembly from an individual female Andrena minutula (the common mini-mining bee; Arthropoda; Insecta; Hymenoptera; Andrenidae). The genome sequence is 380 megabases in span. Most of the assembly (92.19%) is scaffolded into seven chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 17.7 kilobases in length. Gene annotation of this assembly on Ensembl has identified 10,936 protein coding genes.
‘Pretie conveyance’: Jack Juggler and the Idea of Play
Authors: Matuska Agnes
Published: December 2022

This essay addresses the controversy around the antitheatrical epilogue to the anonymous Tudor play Jack Juggler. Based on a close reading of heterogenous voices in the prologue combined with analysis of diverse traditions of playing invoked by the drama, it argues that the audience’s communal authority, centred in a shared experience of watching this comedy, threatens the epilogue’s pedantic, single-voice authority.
‘Riddling Shrift': Confession, Speech, and Power in Romeo and Juliet and ‘Tis Pity She’s a Whore
Authors: Wanninger Jane
Published: December 2022

This essay maps the complex intersubjective dynamics of confession as illuminated in William Shakespeare’s Romeo and Juliet and John Ford’s ‘Tis Pity She’s a Whore, plays in which the ritual of shrift has a pivotal narrative and thematic role. The essay focuses on the friar characters and the office of shrift with which they were associated, and argues that Shakespeare and Ford draw on the durable cultural currency of auricular confession in post-Reformation England to ultimately disruptive ends, as characters consistently and increasingly reconfigure the intersubjective scripts of confession, using its conventions to draft new architectures of performative power.
Introduction: Repertory, Dramaturgy, and Embodiment
Authors: Tavares Elizabeth , Johnson Laurie
Published: December 2022

This introduction outlines the essays in the Early Theatre Issues in Review forum ‘Playing in Repertory’, placing them in the context of new movements in the study of early modern English repertories for contemporaneous and contemporary performance.
Premodern Critical Race Studies and the Question of History
Authors: Corredera Vanessa I.
Published: December 2022

N/A
Percentage of swimmer's coach needs for the development of applications for the physical conditions of swimming
Authors: Falaahudin Ardhika , Suharjana Suharjana , Sumarjo Sumarjo
Published: December 2022

Swimming is a great sport for keeping fit and fresh because it requires all parts of the body to remain actively moving in the water and because of the weight of the body's resistance to water. The trainer's inability to provide an understanding of physical exercise, design a training program, and comprehend the dosage of athlete training is the root cause of the athlete's diminished physical ability. The purpose of this research is to find out percentage of swimmer's coach needs for the development of applications for the physical conditions of swimming. A survey based quantitative descriptive approach is utilized in this study. The participants in this study were 5 Yogyakarta swimming club coaches. The total sampling method was used to select 5 club coaches for this study's sample. In this study, a questionnaire instrument with a Likert scale. The data in this study were analyzed using descriptive analysis with SPSS version 25. Based on the research results obtained data percentage of trainer needs regarding the application of the physical condition of swimming in the high category, obtaining a percentage of 80% with a total of 4 trainers and a moderate percentage of 20% consisting of 1 trainer. Therefore, it can be concluded that the swimmer's coach is highly dependent on the application of the swimming sport's physical condition.
Social Media as a Recipient and Creator of Political Actions in the Context of the Security Crisis
Authors: Danek Magdalena
Published: December 2022

Social media is not only an increasingly popular communication channel or business tool, but also one of the arsenals of information warfare. The next phase of Russia’s war against Ukraine, launched on February 24, 2022, showed once again that the content disseminated through it is used not only to provide actual information or to improve the organisation of assistance to refugees, but also to spread disinformation and propaganda. The aim of the article is to analyse the current status of social media platforms as tools of influence and power – particularly during the war in Ukraine – as well as activities aimed at combating disinformation, especially in the context of the activities of the EU, selected state actors and the owners of these platforms themselves (in this aspect, the analysis will include the activities of Meta and Twitter). The research hypothesis is based on the assumption that social media is, in the scope of the present issue, not only the recipient of political decisions made by legitimised actors, but – by virtue of their power over the flow of a significant amount of information – it become an important actor in these activities in terms of influencing political processes and decision-making centres (e.g., by arbitrarily deciding on the visibility of hate speech content in situations of armed conflict).
The Russia-Ukraine War. Two Strategies of Communication?
Authors: Ślufińska Monika
Published: December 2022

In the aftermath of the Russian invasion of Ukraine, reflections on the communication strategies and tactics used to perform tasks that form part of an information war have again become a topical question. The objective of this paper is, therefore, to analyse the strategic communication practices used during the Russia-Ukraine war. It also attempts to examine the wartime effectiveness of using such forms of communication as propaganda, disinformation, or fake news, as well as techniques used to uncover the false information being spread. The article formulates the following research hypotheses: H1. The Russia-Ukraine war is an example of a new approach to information war. H2. Both sides of the Russian-Ukrainian conflict use different communication strategies. H3. The information war waged during the Russian-Ukrainian conflict is a method of pursuing military, political and economic goals.
Bilevel Memetic Search Approach to the Soft-Clustered Vehicle Routing Problem
Authors: Zhou Yangming , Kou Yawen , Zhou MengChu
Published: December 2022

This work addresses a soft-clustered vehicle routing problem that extends the classical capacitated vehicle routing problem with one additional constraint, that is, customers are partitioned into clusters and all customers of the same cluster must be served by the same vehicle. Its potential applications include parcel delivery in courier companies and freight transportation. Due to its NP-hard nature, solving it is computationally challenging. This paper presents an efficient bilevel memetic search method to do so, which explores search space at both cluster and customer levels. It integrates three distinct modules: a group matching-based crossover (to generate promising offspring solutions), a bilevel hybrid neighborhood search (to perform local optimization), and a tabu-driven population reconstruction strategy (to help the search escape from local optima). Extensive experiments on three sets of 390 widely used public benchmark instances are conducted. The results convincingly demonstrate that the proposed method achieves much better overall performance than state-of-the-art algorithms in terms of both solution quality and computation time. In particular, it is able to find 20 new upper bounds for large-scale instances while matching the best-known upper bounds for all but four of the remaining instances. Ablation studies on three key algorithm modules are also performed to demonstrate the novelty and effectiveness of the proposed ideas and strategies.

Funding: This work was supported by the Macau Young Scholars Program [Grant AM2020011], Fundo para o Desenvolvimento das Cienciase da Tecnologia (FDCT) [Grant 0047/2021/A1], the National Natural Science Foundation of China [Grants 61903144, 71871142, and 71931007], and the Open Project of the Shenzhen Institute of Artificial Intelligence and Robotics for Society [Grant AC01202005002].

Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2022.1186 .
Penegakan Hukum terhadap Penyelesaian Tindak Pidana Penganiayaan oleh Anak melalui Restorative Justice
Authors: Wibisono Arya , Wedowaty Yeni
Published: December 2022

Indonesia merupakan salah satu negara yang memiliki populasi manusia yang tinggi, maka dari itu di dalam seluruh lapisan masyarakat memiliki pemikiran serta taraf hidup yang berbeda-beda. Dengan adanya kemajuan teknologi informasi maka setiap orang dengan mudah memperoleh informasi berbeda-beda dari mana saja. Tak dapat dipungkiri dikarenakan kemajuan teknologi yang pesat membuat masyarakat semakin tahu akan beberapa ilmu dan peristiwa yang sedang terjadi di tengah masyarakat. Dilihat dari sisi negatif dari perkembangan teknologi yaitu semakin maraknya tingkat kejahatan karena banyak cara untuk melakukan segala tindak pidana apapun. Selain dari teknologi informasi yang berkembang sangat pesat, ada beberapa faktor lain mempengaruhi tindak kejahatan seperti keimanan, ilmu pengetahuan, serta pengaruh dari lingkungan sekitar. Biasanya tindak pidana terutama tindak pidana penganiayaan banyak dilakukan oleh orang yang sudah dewasa, tetapi dengan adanya beberapa faktor pendorong maka anak-anak dibawah umur pun melakukan tindak penganiayaan tersebut tanpa melihat siapa yang menjadi sasaran nya. Dikarenakan yang melakukan tindak pidana penganiayaan tersebut adalah seorang anak-anak maka harus diperlakukan secara khusus, mengingat seorang anak masih memiliki masa depan. Maka dari itu perlu ditekan kan nya penyelesaian masalah secara restoratif justice, agar di dalam penyelesaian nya mencapai keadilan yang dapat dirasakan kedua belah pihak. Dalam pelaksanaan nya pun harus mendapatkan dukungan dari aturan yang berlaku itu sendiri serta lingkungan masyarakat tersebut.
Pentingnya Perlindungan Data Pribadi Konsumen dalam Transaksi Online pada Marketplace terhadap Kepuasan Konsumen
Authors: Aryani Almira Putri , Susanti Liana Endah
Published: December 2022

Marketplace adalah platform yang berperan sebagai pihak ketiga atau perantara antara penjual dan pembeli untuk mempermudah transaksi jual beli secara online. Jenis–jenis dari marketplace terbagi menjadi dua, yaitu murni dan konsinyasi. Marketplace murni mempunyai peran penting sebagai fasilitator antara penjual dan pembeli, sedangkan marketplace konsinyasi merupakan jenis pasar daring yang mana penjual hanya memiliki akses untuk menitipkan produk. Marketplace sangatlah menguntungkan bagi banyak pihak dan kegiatan bertransaksi melalui online marketplace juga memiliki dampak negatif yang dapat menimbulkan kerugian bagi pihak konsumen pengguna marketplace. Salah satu contoh adanya ancaman kejahatan pada e-commerce seperti halnya cyber law dan masih banyak lagi. Konsumen marketplace harus mengetahui tata cara bertransaksi secara online dengan benar dan tepat guna meminimalisir adanya resiko-resiko seperti kecurangan-kecurangan atau penipuan utamanya terkait penyalahgunaan data konsumen yang dapat merugikan pihak konsumen itu sendiri. Artikel ini bertujuan mengkaji pentingnya perlindungan data konsumen dalam transaksi online pada marketplace terhadap kepuasan konsumen, dikarenakan perlindungan data pribadi konsumen belum dapat diwujudkan. Hal ini dapat dilihat adanya berbagai kasus terkait penyalahgunaan data pribadi konsumen dan untuk mencapai tujuan tersebut maka dilakukan kajian menggunakan penelitian hukum normatif atau doktrinal dengan bahan hukum primer, sekunder dan tersier yang diperoleh melalui studi pustaka yang kemudian dianalisis. Hasil kajian menunjukkan bahwa keamanan data pribadi konsumen sangat berpengaruh terhadap kepuasan konsumen dan keamanan data pribadi merupakan hal yang penting bagi pengguna E-Commerce.
UNICEF dan Perekrutan Tentara Anak di Republik Demokrasi Kongo: Studi Hukum Humaniter Internasional
Authors: Setyaningrum Wita , Fitriyandi Gusti , Khakim Mufti
Published: December 2022

Konflik di Republik Demokratik Kongo adalah sebuah konflik antar suku yang menewaskan banyak warga sipil sehingga menyebabkan pelanggaran Hak Asasi Manusia (HAM), konflik tersebut terjadi selama dua dekade yaitu tahun 1996-1997 dan 1998-2003 yang mana dalam konflik tersebut menggunakan tentara anak, hal ini membuat United Nations Children’s Fund (UNICEF) dan mitranya bergerak untuk menyelamatkan mereka dari genggaman angkatan bersenjata pemerintah dan kelompok milisi bersenjata. Penelitian ini membahas dua pokok permasalahan, yaitu mengenai mekanisme perekrutan tentara anak dan peranan UNICEF dalam mencegah eksploitasi anak. Penelitian ini mempunyai dua tujuan utama yakni, 1) untuk mengetahui mekanisme perekrutan tentara anak; dan 2) untuk mengetahui peranan United Nations Children’s Fund (UNICEF) dalam mencegah eksploitasi anak di Republik Demokratik Kongo. Penelitian ini merupakan penelitian hukum normatif. Sumber data yang digunakan dalam penelitian ini yaitu bahan hukum primer dan bahan hukum sekunder serta tersier. Kemudian teknik analisis data dilakukan berdasarkan kepustakaan (Library Research), jurnal dan internet selanjutnya disimpulkan. Berdasarkan hasil penelitian yang penulis lakukan bahwa perekrutan tentara anak menggunakan cara penculikan dan propaganda, bergabungnya anak-anak juga karena sukarela sebab tekanan terhadap orang terdekatnya. Selanjutnya United Nations Children’s Fund (UNICEF) dalam penyelamatan bekerja sama antar mitra kerja yaitu melaksanakan program negosiasi dengan kelompok bersenjata yang merekrut anak-anak, menjaga perdamaian serta pengembalian kondisi kesehatan dan pendidikan anak-anak di Republik Demokratik Kongo dengan acuan hukum internasional yang berlaku.
APPLICATION OF AHP AND GIS FOR OPTIMAL SOLAR SITE IDENTIFICATION IN MADHESH PROVINCE, NEPAL
Authors: Shrestha Ravi Raj , Acharya Anushilan , Karmacharya Niroj , Sapkota Mira , Paudyal Binay , Basnet Prasant , Timilsina Sushil , Shakya Hitendra Dev
Published: December 2022

Solar-based renewable energy adoption is in its early stage in the power system of Nepal complying with its commitment to carbon neutrality. The government of Nepal has declared a goal of setting up solar power plants of at least 200 MW in Madhesh Province, but the selection of optimal sites will be the decisive factor in achieving this goal. Therefore, rigorous investigation is necessary for optimal site selection. A three-step framework combining the Analytic Hierarchy Process (AHP) and the Geographical Information System (GIS) has been adopted to identify the optimal location for solar power plant installation in Madhesh Province. The framework includes the creation of weighted individual raster images for the different criteria, images of restricted areas for solar installation, and a combination of all the rasters into a single raster using GIS-based software. The weights of the criteria and sub-criteria have been evaluated using the AHP model, which is an expert judgments-based model. The criteria considered were solar irradiance, annual mean temperature, distance from the road, distance from the substation, distance from the urban area, elevation, aspect, and land use. The results were graded from the least preferred area to the most highly suitable area. The most highly suitable areas were in the Saptari, Siraha, Dhanusa, and Mahottari districts, while the districts in the western region of the province had less suitable areas. Thus, the province’s eastern region is most suitable for installing solar power plants.
A Novel Integrative Methodology for Research on Pot-honey Variations During Post-harvest
Authors: Vit Patricia , Chuttong Bajaree , Zawawi Norhasnida , Diaz Maria , Van der Meulen Jane , Ahmad Hajar F. , Tomas-Barberan Francisco A. , Meccia Gina , Danmek Khanchai , Moreno Jorge Enrique , Roubik David W. , Barth Ortrud Monika , Lachenmeier Dirk W. , Engel Michael S.
Published: December 2022

This novel review of analytical methods for pot-honey research was intended to provide concise references to a 35-day post-harvest experiments at 30 °C, in an integrated study. Diverse methods were selected from specialized literature, from the AOAC (Association of Official Analytical Chemists), and the International Honey Commission. Besides the geographical and seasonal origin, the pot-honey I.D. consists of entomological and botanical identifications, the latter performed by acetolyzed or natural melissopalynology. The methods of this integrative study included: 1. Physicochemical analysis (Aw, color, moisture, pH, free acidity, lactone acidity, total acidity, hydroxymethylfurfural (HMF), and sugars by highperformance liquid chromatography HPLC), 2. Targeted proton nuclear magnetic resonance 1H-NMR metabolomics (sugars, ethanol, HMF, aliphatic organic acids, amino acids, and botanical markers), 3. Biochemical composition (flavonoids, polyphenols), 4. Antioxidant activity (ABTS 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid-free radical scavenging assay, DPPH 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay, ferric reduction assay FRAP), 5. Microbial counts (aerobic plate, yeast and mold, Bacillus, and lactic acid bacteria count), 6. Honey microbiome profiling via independent-culture method: high-throughput bacteria and fungi based on amplicon sequencing approaches, 7. Sensory evaluation (odor, aroma, taste, persistence), and 8. Honey authenticity and biosurfactant tests by an interphase emulsion. A further section was included to provide basic information on the results obtained using each method. This was needed to explain the interacting components derived from pot-honey processing within the stingless bee nest and post-harvest transformations.