bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact on Patient Management of a Novel Host Response Test for Distinguishing Bacterial and Viral Infections: Real World Evidence from the Urgent Care Setting
Authors: Kalmovich Boaz , Rahamim-Cohen Daniella , Shapiro Ben David Shirley
Published: May 2023

Antibiotic overuse and underuse are prevalent in urgent care settings, driven in part by diagnostic uncertainty. A host-based test for distinguishing bacterial and viral infections (MeMed BV) has been clinically validated previously. Here we examined how BV impacts antibiotic prescription in a real-world setting. The intention to treat with antibiotics before the receipt of a BV result was compared with practice after the receipt of a BV result at three urgent care centers. The analysis included 152 patients, 57.9% children and 50.7% female. In total, 131 (86.2%) had a bacterial or viral BV result. Physicians were uncertain about prescription for 38 (29.0%) patients and for 30 (78.9%) of these cases, subsequently acted in accordance with the BV result. Physicians intended to prescribe antibiotics to 39 (29.8%) patients, of whom 17 (43.6%) had bacterial BV results. Among the remaining 22 patients with viral BV results, antibiotic prescriptions were reduced by 40.9%. Overall, the physician prescribed in accordance with BV results in 81.7% of all cases (p < 0.05). In total, the physicians reported that BV supported or altered their decision making in 87.0% of cases (p < 0.05). BV impacts patient management in real-world settings, supporting appropriate antibiotic use.
Low-Dose Aspirin after ASPRE—More Questions Than Answers? Current International Approach after PE Screening in the First Trimester
Authors: Tousty Piotr , Fraszczyk-Tousty Magda , Dzidek Sylwia , Jasiak-Jóźwik Hanna , Michalczyk Kaja , Kwiatkowska Ewa , Cymbaluk-Płoska Aneta , Torbé Andrzej , Kwiatkowski Sebastian
Published: May 2023

Preeclampsia (PE) is a multi-factorial disorder of pregnancy, and it continues to be one of the leading causes of fetal and maternal morbidity and mortality worldwide. Aspirin is universally recommended for high-risk women to reduce preeclampsia risk. The purpose of this review is to summarize the recommendations of various scientific societies on predicting preeclampsia and their indications for the inclusion of acetylsalicylic acid (ASA) prophylaxis. Fourteen guidelines were compared. The recommended dose, screening method, and gestational age at the start of the test vary depending on the recommendation. The societies are inclined to recommend using increasingly higher doses (>75 mg) of ASA, with many encouraging doses from 100 mg upward. Most societies indicate that the optimal time for implementing aspirin is prior to 16 weeks’ gestation. Following the publication of the Aspirin for Evidence-Based Preeclampsia Prevention (ASPRE) trial results and other papers evaluating the Fetal Medicine Foundation (FMF) screening model, a large number of societies have changed their recommendations from those based on risk factors alone to the ones based on the risk assessment proposed by the FMF. This allows for the detection of a high-risk pregnancy population in whom aspirin will be remarkably effective in preventing preterm PE, thereby decreasing maternal and fetal morbidity.
Development of a Decision Support Tool for Anticoagulation in Critically Ill Patients Admitted for SARS-CoV-2 Infection: The CALT Protocol
Authors: Dubar Victoria , Pascreau Tiffany , Dupont Annabelle , Dubucquoi Sylvain , Dautigny Anne-Laure , Ghozlan Benoit , Zuber Benjamin , Mellot François , Vasse Marc , Susen Sophie , Poissy Julien , Gaudet Alexandre
Published: May 2023

Severe COVID-19 infections are at high risk of causing thromboembolic events (TEEs). However, the usual exams may be unavailable or unreliable in predicting the risk of TEEs at admission or during hospitalization. We performed a retrospective analysis of two centers (n = 124 patients) including severe COVID-19 patients to determine the specific risk factors of TEEs in SARS-CoV-2 infection at admission and during stays at the intensive care unit (ICU). We used stepwise regression to create two composite scores in order to predict TEEs in the first 48 h (H0–H48) and during the first 15 days (D1–D15) in ICU. We then evaluated the performance of our scores in our cohort. During the period H0–H48, patients with a TEE diagnosis had higher D-Dimers and ferritin values at day 1 (D1) and day 3 (D3) and a greater drop in fibrinogen between D1 and D3 compared with patients without TEEs. Over the period D1-D15, patients with a diagnosis of a TEE showed a more marked drop in fibrinogen and had higher D-Dimers and lactate dehydrogenase (LDH) values at D1 and D3. Based on ROC analysis, the COVID-related acute lung and deep vein thrombosis (CALT) 1 score, calculated at D1, had a diagnostic performance for TEEs at H0–H48, estimated using an area under the curve (AUC) of 0.85 (CI95%: 0.76–0.93, p < 10−3). The CALT 2 score, calculated at D3, predicted the occurrence of TEEs over the period D1-D15 with an estimated AUC of 0.85 (CI95%: 0.77–0.93, p < 10−3). These two scores were used as the basis for the development of the CALT protocol, a tool to assist in the decision to use anticoagulation during severe SARS-CoV-2 infections. The CALT scores showed good performances in predicting the risk of TEEs in severe COVID-19 patients at admission and during ICU stays. They could, therefore, be used as a decision support protocol on whether or not to initiate therapeutic anticoagulation.
New Synthesized Activating Transcription Factor 3 Inducer SW20.1 Suppresses Resistin-Induced Metabolic Syndrome
Authors: Tran Tu T. , Huang Wei-Jan , Lin Heng , Chen Hsi-Hsien
Published: May 2023

Obesity is an emerging concern globally with increasing prevalence. Obesity is associated with many diseases, such as cardiovascular disease, dyslipidemia, and cancer. Thus, effective new antiobesity drugs should be urgently developed. We synthesized SW20.1, a compound that induces activating transcription factor 3 (ATF3) expression. The results of Oil Red O staining and quantitative real-time polymerase chain reaction revealed that SW20.1 was more effective in reducing lipid accumulation in 3T3-L1 preadipocytes than the previously synthesized ST32db, and that it inhibited the expression of the genes involved in adipogenesis and lipogenesis. A chromatin immunoprecipitation assay indicated that SW20.1 inhibited adipogenesis and lipogenesis by binding to the upstream promoter region of resistin at two sites (−2861/−2854 and −241/−234). In mice, the intraperitoneal administration of SW20.1 reduced body weight, white adipocyte weight in different regions, serum cholesterol levels, adipogenesis-related gene expression, hepatic steatosis, and serum resistin levels. Overall, SW20.1 exerts antiobesity effects by inhibiting resistin through the ATF3 pathway. Our study results indicate that SW20.1 is a promising therapeutic drug for diet-induced obesity.
The Level of Intima-Media Thickness in Patients with Metabolic Syndrome in Poland Depending on the Prevalence of Type 2 Diabetes
Authors: Gierach Marcin , Junik Roman
Published: May 2023

Background: Metabolic syndrome (MetS), increasingly diagnosed among the Polish population, is a combination of factors that are associated with an increased risk of atherosclerosis and cardiovascular diseases. Intima-media thickness (IMT) of the common carotid artery has been suggested as, simply, a non-invasive and reproducible marker of the early stages of the atherosclerotic process. The carotid IMT can also be a strong predictor of future cerebral and cardiovascular events. The aim of our study was to evaluate atherosclerotic lesions in carotid vessels in patients with MetS depending on the presence of DMt2 and to assess which demographic factors affect the level of IMT. The study involved 335 subjects diagnosed with MetS, including 211 females (65%) and 124 males (37%) aged 37–82. The diagnosis of MetS was made on the basis of the International Diabetes Federation (IDF) criteria. The patients were divided into two subgroups: with DMt2 and without DMt2. The value of IMT depended on gender, education, and smoking status. We noticed that patients with DMt2 had the highest measurement of IMT compared with other groups (1.01 vs. 0.98). Additionally, a statistically significant difference between the subgroup with DMt2 and those without DMt2 was found (1.01 vs. 0.92; p < 0.005). Ultrasound assessment of the carotid IMT should be used more often in the diagnosis and monitoring of high cardiovascular risk and early progression of atherosclerosis, especially in patients with MetS with current DMt2.
Noninvasive Electrical Stimulation Neuromodulation and Digital Brain Technology: A Review
Authors: Zhang Shuang , Qin Yuping , Wang Jiujiang , Yu Yuanyu , Wu Lin , Zhang Tao
Published: May 2023

We review the research progress on noninvasive neural regulatory systems through system design and theoretical guidance. We provide an overview of the development history of noninvasive neuromodulation technology, focusing on system design. We also discuss typical cases of neuromodulation that use modern noninvasive electrical stimulation and the main limitations associated with this technology. In addition, we propose a closed-loop system design solution of the “time domain”, “space domain”, and “multi-electrode combination”. For theoretical guidance, this paper provides an overview of the “digital brain” development process used for noninvasive electrical-stimulation-targeted modeling and the development of “digital human” programs in various countries. We also summarize the core problems of the existing “digital brain” used for noninvasive electrical-stimulation-targeted modeling according to the existing achievements and propose segmenting the tissue. For this, the tissue parameters of a multimodal image obtained from a fresh cadaver were considered as an index. The digital projection of the multimodal image of the brain of a living individual was implemented, following which the segmented tissues could be reconstructed to obtain a “digital twin brain” model with personalized tissue structure differences. The “closed-loop system” and “personalized digital twin brain” not only enable the noninvasive electrical stimulation of neuromodulation to achieve the visualization of the results and adaptive regulation of the stimulation parameters but also enable the system to have individual differences and more accurate stimulation.
Bionic Artificial Neural Networks in Medical Image Analysis
Authors: Wang Shuihua , Chen Huiling , Zhang Yudong
Published: May 2023

Bionic artificial neural networks (BANNs) are a type of artificial neural network (ANN) [...]
Adaptive Image Enhancement Algorithm Based on Variable Step Fruit Fly Optimization Algorithm and Nonlinear Beta Transform
Authors: Huang Huajuan , Tao Dao , Wei Xiuxi , Zhou Yongquan
Published: May 2023

Due to the traditional use of manual methods for the parameter adjustment of a nonlinear beta transform, which is inefficient and unstable, an adaptive image enhancement algorithm based on a variable step size fruit fly optimization algorithm and a nonlinear beta transform is proposed. Utilizing the intelligent optimization characteristics of the fruit fly algorithm, we automatically optimize the adjustment parameters of a nonlinear beta transform to achieve better image enhancement effects. Firstly, the dynamic step size mechanism is introduced into the fruit fly optimization algorithm (FOA) to obtain a variable step size fruit fly optimization algorithm (VFOA). Then, with the adjustment parameters of the nonlinear beta transform as the optimization object, and the gray variance of the image as the fitness function, an adaptive image enhancement algorithm (VFOA-Beta) is obtained by combining the improved fruit fly optimization algorithm with the nonlinear beta function. Finally, nine sets of photos were used to test the VFOA-Beta algorithm, while seven other algorithms were used for comparative experiments. The test results show that the VFOA-Beta algorithm can significantly enhance images and achieve better visual effects, which has a certain practical application value.
Changes in Distance between a Wearable Robotic Exoskeleton User and Four-Wheeled Walker during Gait in Level and Slope Conditions: Implications for Fall Prevention Systems
Authors: Tan Koki , Koyama Soichiro , Sakurai Hiroaki , Kanada Yoshikiyo , Tanabe Shigeo
Published: May 2023

When walking with wearable robotic exoskeletons (WRE) in people with spinal cord injury, the distance between the user and the walker is one of the most important perspectives for ensuring safety. The purpose of this study was to clarify the distance between WRE users and four-wheeled walkers (4WW) while walking on level and sloping surfaces. To eliminate the effects of variation in neurological conditions, 12 healthy subjects participated. All participants ambulated using the WRE and the 4WW on level and sloping surfaces. The outcomes were the mean distances between the WRE users and the 4WWs in the level and slope conditions. To examine the influence of uphill and downhill slopes on distance, comparisons were conducted between the uphill or downhill conditions and the respective transitional periods. In the uphill condition, the mean distances were significantly greater than that in the level condition. Conversely, the mean distance moving downhill was significantly shorter than that in the level condition. Changes in the distance between the WRE user and the 4WW might increase the risk of falling forward on an uphill slope and backward on a downhill slope. This study’s results will assist in developing a new feedback system to prevent falls.
Cost of Transport of Undulating Fin Propulsion
Authors: Vercruyssen Tim G. A. , Henrion Sebastian , Müller Ulrike K. , van Leeuwen Johan L. , van der Helm Frans C. T.
Published: May 2023

Autonomous robots are used to inspect, repair and maintain underwater assets. These tasks require energy-efficient robots, including efficient movement to extend available operational time. To examine the suitability of a propulsion system based on undulating fins, we built two robots with one and two fins, respectively, and conducted a parametric study for combinations of frequency, amplitude, wavenumber and fin shapes in free-swimming experiments, measuring steady-state swimming speed, power consumption and cost of transport. The following trends emerged for both robots. Swimming speed was more strongly affected by frequency than amplitude across the examined wavenumbers and fin heights. Power consumption was sensitive to frequency at low wavenumbers, and increasingly sensitive to amplitude at high wavenumbers. This increasing sensitivity of amplitude was more pronounced in tall rather than short fins. Cost of transport showed a complex relation with fin size and kinematics and changed drastically across the mapped parameter space. At equal fin kinematics as the single-finned robot, the double-finned robot swam slightly faster (>10%) with slightly lower power consumption (<20%) and cost of transport (<40%). Overall, the robots perform similarly to finned biological swimmers and other bio-inspired robots, but do not outperform robots with conventional propulsion systems.
Ultimate Strength Study of Structural Bionic CFRP-Sinker Bolt Assemblies Subjected to Preload under Three-Point Bending
Authors: Qin Zhengqi , He Ying , Wang Shengwu , Meng Cunying
Published: May 2023

Countersunk head bolted joints are one of the main approaches to joining carbon fiber-reinforced plastics, or CFRP. In this paper, the failure mode and damage evolution of CFRP countersunk bolt components under bending load are studied by imitating water bears, which are born as adult animals and have strong adaptability to life. Based on the Hashin failure criterion, we establish a 3D finite element failure prediction model of a CFRP-countersunk bolted assembly, benchmarked with the experiment. The analysis shows that the simulation results under specified parameters have a good correlation with the experimental results, and can better reflect the three-point bending failure and fracture of the CFRP-countersunk bolted assembly. Based on the specified parameter of the carbon lamina material change, we used the countersunk bolt preload to investigate the stress distribution near the counterbore zone, and to investigate the effect of bolt load on the three-point bending limit load. The results obtained using FEA calculations indicate that the stress distribution around the countersunk hole is related to the laminate direction. The bolt preloading force increasing reduces the load value at the initial damage, and the appropriate preload force will increase the ultimate load of the joint.
Time-Dependent Demineralization of Tilapia (Oreochromis niloticus) Bones Using Hydrochloric Acid for Extracellular Matrix Extraction
Authors: Nisperos Michael John , Bacosa Hernando , Lumancas Gladine , Arellano Fernan , Aron Jemwel , Baclayon Lean , Bantilan Zesreal Cain , Labares Marionilo , Bual Ronald
Published: May 2023

Tilapia (Oreochromis niloticus) is a widely cultivated fish in tropical and subtropical regions such as the Philippines, generating substantial waste during processing, including bones that are a valuable source of extracellular matrix (ECM). However, the extraction of ECM from fish bones requires an essential step of demineralization. This study aimed to assess the efficiency of tilapia bone demineralization using 0.5 N HCl at different time durations. By evaluating the residual calcium concentration, reaction kinetics, protein content, and extracellular matrix (ECM) integrity through histological analysis, composition assessment, and thermal analysis, the effectiveness of the process was determined. Results revealed that after 1 h of demineralization, the calcium and protein contents were 1.10 ± 0.12% and 88.7 ± 0.58 μg/mL, respectively. The study found that after 6 h, the calcium content was almost completely removed, but the protein content was only 51.7 ± 1.52 μg/mL compared to 109.0 ± 1.0 μg/mL in native bone tissue. Additionally, the demineralization reaction followed second-order kinetics with an R2 value of 0.9964. Histological analysis using H&E staining revealed a gradual disappearance of the basophilic components and the emergence of lacunae, which can be attributed to decellularization and mineral content removal, respectively. As a result, organic components such as collagen remained in the bone samples. ATR-FTIR analysis showed that all demineralized bone samples retained collagen type I markers, including amide I, II, and III, amides A and B, and symmetric and antisymmetric CH2 bands. These findings provide a route for developing an effective demineralization protocol to extract high-quality ECM from fish bones, which could have important nutraceutical and biomedical applications.
A New View on the Global Redox-Cycle of Biosphere Carbon
Authors: Ivlev A. A.
Published: May 2023

The global carbon cycle model is presented as a natural self-regulating machine that provides renewable biomass synthesis during evolution. The machine consists of two parts, geological and biosphere. Between the parts, there is an interaction. The geological part is controlled by the movement of lithosphere plates, which is under the guidance of gravitational forces from celestial bodies acting on the Earth. The movement of the lithosphere plates is divided into a phase of a relatively quick movement, occurring in the tectonically active state of the Earth’s crust, named the orogenic period, and a phase of a relatively slow movement, occurring in the phase of the tectonically quiet state of the crust, named geosynclinal period. In the orogenic period, the energy of moving plates’ collisions is sufficient to initiate sulfate reduction, proceeding in the subduction zone. This is the reaction where sedimentary organic matter is oxidized. Resultant CO2 is injected into “atmosphere—hydrosphere” system of the Earth. Its concentration achieves maximal values, whereas oxygen concentration drops to a minimum since it reacts with the reduced sulfur forms that evolve in the thermochemical sulfate reduction and due to binding with reduced forms of metals, coming to the Earth’s surface with volcanic exhalations. Carbon dioxide initiates photosynthesis and the associated biosphere events. In the geosynclinal period, the sulfate reduction ceases, and CO2 does not enter the system anymore, though photosynthesis in the biosphere proceeds in the regime of CO2 pool depletion. Under such conditions, the surface temperature on the Earth decreases, ending with glaciations. The successive depletion of the CO2 pool results in a regular sequence of climatic changes on the Earth. The ratio of CO2/O2 is the key environmental parameter in the orogenic cycle providing climatic changes. They consistently vary from hot and anaerobic in the orogenic period to glacial and aerobic by the end of the geosynclinal period. The climatic changes provide biotic turnover. Especially abrupt changes accompany the transition to a new orogenic cycle, resulting in mass extinction of organisms and the entry of huge masses of biogenic material into the sediment. This provided the conditions for the formation of rocks rich in organic matter (“black shales”). It is shown that the suggested model is supported by numerous geological and paleontological data evidencing the orogenic cycles’ existence and their relationship with the evolution of photosynthesis.
V6O13 Micro-Flower Arrays Grown In Situ on Ni Foam as Efficient Electrocatalysts for Hydrogen Evolution at Large Current Densities
Authors: Xie Yajie , Huang Jianfeng , Wang Yufei , Cao Liyun , Zhao Yong , Kajiyoshi Koji , Liu Yijun , Feng Liangliang
Published: May 2023

Developing a high-activity, robust and economic electrocatalyst for large-scale green hydrogen production is still of great significance. Herein, a novel V6O13 nanosheets self-assembled micro-flower array self-supporting electrode is synthesized using a facile one-pot hydrothermal route. Owing to the large electrochemically active surface area of a unique hierarchical micro-flower and the stable all-in-one structure, the as-prepared V6O13/NF electrode delivers impressive HER activity with extremely low overpotentials of 125 and 298 mV at large current densities of 100 and 1000 mA cm−2, respectively, and a long-term durability for at least 90 h in an alkaline condition. This work extends the application of vanadium oxides to the realm of electrocatalytic hydrogen fuel production.
Visible-Light-Induced Difunctionalization of the C-C Bond of Alkylidenecyclopropanes with Acyl Chlorides
Authors: Ding Chuan , Huang Peng-Fei , Xiong Biquan , Tang Ke-Wen , Liu Yu
Published: May 2023

A new and powerful visible-light-induced difunctionalization of the C-C σ-bond of alkylidenecyclopropanes via a ring-opening process was developed. Importantly, acyl chlorides are used as both acyl and Cl sources. This strategy provides an effective route for the difunctionalization of the C-C bond with an acyl radical and Cl− to construct a new C-C bond and a C-Cl bond in one pot. In addition, it has a wide range of substrates and can tolerate various functional groups.
Roles of Aging, Circular RNAs, and RNA Editing in the Pathogenesis of Amyotrophic Lateral Sclerosis: Potential Biomarkers and Therapeutic Targets
Authors: Hosaka Takashi , Tsuji Hiroshi , Kwak Shin
Published: May 2023

Amyotrophic lateral sclerosis (ALS) is an incurable motor neuron disease caused by upper and lower motor neuron death. Despite advances in our understanding of ALS pathogenesis, effective treatment for this fatal disease remains elusive. As aging is a major risk factor for ALS, age-related molecular changes may provide clues for the development of new therapeutic strategies. Dysregulation of age-dependent RNA metabolism plays a pivotal role in the pathogenesis of ALS. In addition, failure of RNA editing at the glutamine/arginine (Q/R) site of GluA2 mRNA causes excitotoxicity due to excessive Ca2+ influx through Ca2+-permeable α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors, which is recognized as an underlying mechanism of motor neuron death in ALS. Circular RNAs (circRNAs), a circular form of cognate RNA generated by back-splicing, are abundant in the brain and accumulate with age. Hence, they are assumed to play a role in neurodegeneration. Emerging evidence has demonstrated that age-related dysregulation of RNA editing and changes in circRNA expression are involved in ALS pathogenesis. Herein, we review the potential associations between age-dependent changes in circRNAs and RNA editing, and discuss the possibility of developing new therapies and biomarkers for ALS based on age-related changes in circRNAs and dysregulation of RNA editing.
Double Positive CD4+CD8+ (DP) T-Cells Display Distinct Exhaustion Phenotype in Chronic Hepatitis C
Authors: Kochanowicz Anna Maria , Osuch Sylwia , Berak Hanna , Kumorek Aleksandra , Caraballo Cortés Kamila
Published: May 2023

In chronic hepatitis C (CHC), characterized by exhaustion of T-cell function, increased frequencies of double-positive (DP) (CD4+CD8+) cells are present in peripheral blood. We compared the exhaustion phenotype between DP and single positive (SP) T-cells, including HCV-specific cells, and assessed the effect of successful HCV treatment on inhibitory receptors expression. Blood samples from 97 CHC patients were collected before and six months post-treatment. PD-1 (programmed cell death protein 1) and Tim-3 (T-cell immunoglobulin and mucin domain-containing molecule-3) expression was assessed by flow cytometry. DP T-cells displayed significantly higher PD-1 expression, lower Tim-3 expression than CD8+ SP T-cells and lower percentages of PD-1−Tim-3− cells than CD4+ SP T-cells, both before and after treatment. PD-1+Tim-3+ DP T-cells decreased following treatment. HCV-specific cells were more frequent among DP than SP T-cells, both before and after treatment. HCV-specific DP T-cells were characterized by lower PD-1 expression, higher PD-1 and Tim-3 co-expression, and lower percentages of PD-1−Tim-3− cells (both before and after treatment) and higher post-treatment Tim-3 than HCV-specific SP T-cells. Their percentages decreased following treatment, but the exhaustion phenotype remained unchanged. DP T-cells in CHC exhibit a distinct exhaustion phenotype from SP T-cells, and these changes mostly persist following successful treatment.
Sports Games and Motor Skills in Children, Adolescents and Youth with Intellectual Disabilities
Authors: Aksović Nikola , Dobrescu Tatiana , Bubanj Saša , Bjelica Bojan , Milanović Filip , Kocić Miodrag , Zelenović Milan , Radenković Marko , Nurkić Filip , Nikolić Dejan , Marković Jovan , Tomović Milena , Vulpe Ana-Maria
Published: May 2023

(1) Background: Sports games are one of the best ways of engaging in physical activity for individuals with intellectual disabilities (ID) and Down syndrome (DS). This systematic review of the current literature aims to identify and sum relevant data on motor skills and clarify whether there are positive effects of sports programs in motor skills games in children, adolescents, and youth with ID and DS. (2) Methods: The systematic review of the papers was carried out following the methodological guidelines and by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) consensus. The following electronic databases were researched: PubMed, MEDLINE, Google Scholar, ScienceDirect, and ERIC from 2001 to 2023. (3) Results: The basketball test battery can be used to improve and monitor basketball training. Basketball players with lower levels of ID achieved better results, especially those with disabilities of the II and III degrees. Futsal has a positive impact on the coordination, and the differences between the test results of the vertical jump with and without an arm swing, that can be seen indirectly as a coordination factor, were statistically significant. (4) Conclusions: Basketball is recommended as an effective and practical rehabilitation program for children, adolescents, and youth with ID and DS. Futsal is an interesting and helpful activity for individuals with ID as well.
Supporting Depressed Mothers of Young Children with Intellectual Disability: Feasibility of an Integrated Parenting Intervention in a Low-Income Setting
Authors: Chaudhry Nasim , Sattar Rabia , Kiran Tayyeba , Wan Ming Wai , Husain Mina , Hidayatullah Sobia , Ali Bushra , Shafique Nadia , Suhag Zamir , Saeed Qamar , Maqbool Shazia , Husain Nusrat
Published: May 2023

As a lifelong condition, intellectual disability (ID) remains a public health priority. Parents caring for children with ID experience serious challenges to their wellbeing, including depression, anxiety, stress and health-related quality of life. Integrated parenting interventions, which have been well evidenced for depressed mothers, may also effectively support depressed parents with a child with ID in low-resource settings such as Pakistan, and in turn optimise child outcomes. We conducted a mixed-method rater-blind feasibility randomised controlled trial, which assessed the feasibility and acceptability of the Learning Through Play in My Own Way Plus (LTP-IMOW Plus) intervention. Mothers who screened positive for depression (n = 26) with a young child (age 3–6 years) with ID were recruited from two low-resource community settings. Participants in the intervention arm (n = 13) received 12 group sessions of LTP-IMOW Plus and others (n = 13) received routine care. The intervention was feasible and acceptable with 100% retention and 100% session attendance. The intervention improved depression, anxiety, parenting stress and child socialisation score outcomes relative to the routine care arm. The framework utilised to analyse the qualitative interviews with seven participants at pre-intervention identified a range of struggles experienced by the mothers, and at post-intervention, found improved knowledge of child development and practices, improved mother–child relationships, recommendations for the intervention and perceived practical barriers and facilitators. The findings highlight the prospects for a clinical and cost-effective trial of an integrated parenting intervention to manage long-term parental mental health needs and improve child outcomes.
Determining Positive Behavioral Skills in Different Age Groups of Young Basketball Players during the Pandemic
Authors: Pocius Eimantas , Malinauskas Romualdas
Published: May 2023

Assessing psychological indicators such as positive behavioral skills in the context of adolescent personality development during the pandemic era is highly relevant: the growing problem of peer disrespect among adolescents who participate in sports has recently become an undeniable scientific issue. This study aimed to analyze positive behavioral skills in the cadet (U16) and junior (U18) age groups of young basketball players during the COVID-19 pandemic. The participants were 378 male athletes (age 16.36 ± 1.15 years). Results revealed that U18 athletes are more capable of taking responsibility, positively evaluating themselves, behaving pro-socially with teammates, cooperating, demonstrating assertiveness, demonstrating self-control, and managing emotions than U16 adolescent athletes. When comparing the effect sizes in the current study during the pandemic with similar studies by other authors, the pandemic may have had a larger negative effect on some positive behavioral skills (ability to control emotions, social responsibility skills, cooperation skills) in U16 athletes than in U18 athletes, as the effect sizes were small before the pandemic and moderate during the pandemic in the current study. This study’s results may be useful for developing and implementing a young athletes’ education program based on a comprehensive model of positive behavioral skills that include the indicators analyzed.
Interstitial Lung Disease in Neonates: A Long Road Is Being Paved
Authors: Gabitova N. Kh. , Cherezova I. N. , Arafat Ahmed , Sadykova Dinara
Published: May 2023

Background: Interstitial lung disease (ILD) is one of the most difficult conditions in pulmonology due to difficulties in diagnosing, classifying, and treating this condition. They require invasive approaches to diagnose (e.g., lung biopsy), non-applicable methods (e.g., lung function tests in newborns), or potentially non-accessible methods (e.g., genetic testing in not-well-equipped facilities, and several weeks are required for results to be announced). They represent a heterogeneous group of diseases in which the alveolar epithelium, parenchyma, and capillaries of the lungs are damaged, which leads to changes in the pulmonary interstitium, proliferation of connective tissue, and thickening of the alveolar-capillary membranes and alveolar septa. These changes are accompanied by impaired oxygen diffusion, progressive respiratory failure, and radiographic signs of bilateral dissemination. Although adult and child classifications for ILD have evolved over the years, classification for ILD in neonates remains a challenge. Case presentation: Here we discuss ILD in neonates briefly, and report two rare cases of ILD (a male white neonate, two-day-old with fibrosing alveolitis, and another male white neonate, one-day old with desquamative interstitial pneumonitis), with these diagnoses initially thought to be presented only in adulthood. Lung biopsy and histopathological findings of the two neonates have shown mononuclear cells in the alveolar spaces, and thickening of the alveolar walls confirmed the diagnosis of fibrosing alveolitis in one neonate, and desquamation of the large mononuclear cells in the intra-alveolar space in the other neonate, with the diagnosis of desquamative interstitial pneumonitis being confirmed. Interstitial lung disease lacks a consensus guideline on classification and diagnosis in neonates, rendering it one of the greatest challenges to pediatricians and neonatologists with remarkable morbidity and mortality rates. Conclusions: Fibrosing alveolitis and desquamative interstitial pneumonitis (DIP) are not adult-only conditions, although rare in neonates, histopathological examination and clinical practice can confirm the diagnosis. Based on our clinical practice, prenatal and maternal conditions may serve as potential risk factors for developing IDL in neonates, and further studies are needed to prove this hypothesis.
Immune Response and Immune Checkpoint Molecules in Patients with Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy: A Review
Authors: Koukourakis Ioannis M. , Platoni Kalliopi , Tiniakos Dina , Kouloulias Vassilis , Zygogianni Anna
Published: May 2023

It is well-established that tumor antigens and molecules expressed and secreted by cancer cells trigger innate and adaptive immune responses. These two types of anti-tumor immunity lead to the infiltration of the tumor’s microenvironment by immune cells with either regulatory or cytotoxic properties. Whether this response is associated with tumor eradication after radiotherapy and chemotherapy or regrowth has been a matter of extensive research through the years, mainly focusing on tumor-infiltrating lymphocytes and monocytes and their subtypes, and the expression of immune checkpoint and other immune-related molecules by both immune and cancer cells in the tumor microenvironment. A literature search has been conducted on studies dealing with the immune response in patients with rectal cancer treated with neoadjuvant radiotherapy or chemoradiotherapy, assessing its impact on locoregional control and survival and underlying the potential role of immunotherapy in the treatment of this cancer subtype. Here, we provide an overview of the interactions between local/systemic anti-tumor immunity, cancer-related immune checkpoint, and other immunological pathways and radiotherapy, and how these affect the prognosis of rectal cancer patients. Chemoradiotherapy induces critical immunological changes in the tumor microenvironment and cancer cells that can be exploited for therapeutic interventions in rectal cancer.
Paleoclimate and Paleoenvironment Reconstructions from Middle Eocene Successions at Beni-Suef, Egypt: Foraminiferal Assemblages and Geochemical Approaches
Authors: Sayed Mostafa Mohamed , Heinz Petra , Abd El-Gaied Ibrahim Mohamed , Wagreich Michael
Published: May 2023

The Eocene deposits of Egypt provide a wide variety of shallow marine facies and fossil assemblages, allowing paleoenvironmental reconstructions in this warmhouse climate interval. Forty-three rock samples have been collected from two middle Eocene sections, exposed at southeast Beni-Suef area in northern Egypt. The studied outcrops are lithologicsally subdivided into two rock units named from base to top as follows: (1) the Qarara Formation (Lutetian) and (2) the El Fashn Formation (Bartonian). Most investigated rock samples showed richness in benthic foraminiferal assemblages and only rare occurrences of index planktonic foraminifera. They yielded 160 foraminifera species which belong to 4 suborders, 19 superfamilies, 34 families, and 59 genera. The stratigraphic distribution of the identified species allowed us to define four local benthic bio-ecozones: (1) Bolivina carinata Lowest Occurrence Zone (Lutetian), (2) Cibicides mabahethi/Cancris auriculus primitivus Concurrent-Range Zone, (3) Nonion scaphum Lowest Occurrence Zone, and (4) Brizalina cookei/Nonionella insecta Concurrent-Range Zone (Bartonian). These biozones are described and discussed in detail and correlated to stratigraphic equivalents in Egypt. The rareness of index planktonic foraminifera through the studied sections does not allow a precise biostratigraphic and chronostratigraphic correlation. The shale samples show low TOC values, which may be related to low productivity, high sediment influx, and/or prevailing oxic conditions. Bulk rock geochemistry, consistent with the benthic foraminifera ecological preferences, indicated that the studied sections were deposited in moderate to high oxygen levels and warm climatic conditions in a typical shelf marine setting. The identified species showed strong similarities with nearby southern Tethys areas, reflecting migration via the trans-Sahara seaway, and minor similarities with those identified from the northwestern Tethys and the North Atlantic province attributed to the change in the environmental and climatic conditions, such as cooler, latitudinal zoned climatic conditions along the northwestern Tethys, which was unsuitable for their biological demands. The warming trend identified from Lutetian to Bartonian intervals corresponds to the onset of the Middle Eocene Climatic Optimum (MECO).
Reduction of Cancer Stem Cells and Invasiveness of Human Melanoma and Breast Cancer by Cucurbitacin B from Lagenaria siceraria
Authors: Huang Cheng-Chen , Balding Kiera K. , Zimmerman Sydney J. , Chang Che-Yuan , Lu Si-Min , Huang Hui-Chi
Published: May 2023

Cucurbitacins are secondary metabolites that are commonly found in the Cucurbitacae family. Many biological properties have been reported for cucurbitacins, including anti-inflammatory, antioxidant, antiviral, anti-malaria, and anticancer properties. While studies for the anticancer property of cucurbitacins focus mostly on the cell-cycle progression and apoptosis, no study has considered the effect of cucurbitacin on other cancer behaviors. Here, we report cell-proliferation-based drug testing on random herbal extracts leading to the identification of cucurbitacin B as an anticancer compound. Interestingly, cucurbitacin B had no effect on the proliferation of rat embryonic myoblast cells. We also found that cucurbitacin B significantly reduced the invasiveness of at least two highly metastatic breast cancer and melanoma cells. Using known cancer stem-cell markers, we observed a significant reduction of the melanoma stem cells. Molecularly, cucurbitacin B caused reduction of the metastasis-promoting gene Snail in melanoma and one of the cancer stem cell markers, ALDH1A1 (aldehyde dehydrogenase 1 A1), in breast cancer. Finally, we report the potential toxicity of cucurbitacin B in developing skin tissue and the olfactory organ using zebrafish embryo. In summary, our study suggests the potential use of cucurbitacin B for cancer metastasis and relapse treatment.
How Far Have We Developed Antibody–Drug Conjugate for the Treatment of Cancer?
Authors: Lim Yu Jun , Clarissa Lau Pei Sze , Low Shi Xuan , Ng Shong Li , Ong Min Yee , Pang Huey Ming , Lee Zheng Yang , Yow Hui Yin , Hamzah Sharina Binti , Sellappans Renukha , Foo Jhi Biau
Published: May 2023

Cancer, also known as malignant tumour or neoplasm, is a leading cause of death worldwide. One distinct feature from normal cells is that cancerous cells often overexpress protein on the cell membrane—for instance, the overexpression of human epidermal growth factor receptor 2. The expression of a specific protein on the cancerous cell surface acts as a marker that differentiates the normal cell and facilitates the recognition of cancerous cells. An emerging anticancer treatment, Antibody–Drug Conjugates (ADCs), utilises this unique feature to kill cancerous cells. ADCs consist of an antibody linked with a cytotoxic payload, mainly targeting the antigen found on cancerous cells. This design can increase the specificity in delivering the cytotoxin to the drug target, thus increasing the drug efficacy and reducing the side effect of cancer treatment due to off-target toxicities. There are tremendous quantities of clinical trials conducted to evaluate the safety and effectiveness of this magic drug in treating different types of cancers. However, only 12 ADCs have been approved by the FDA until now. This review provides the principles of ADCs and highlights the ADCs that FDA has approved. In addition, some of the ADCs that undergo clinical trials are discussed in this review. The application of computational techniques in addressing ADCs’ challenges and neoantigen-targeted cancer vaccines is also highlighted. Although ADCs have been seen as promising magic drugs in cancer treatment, the problems such as toxicity, the stability of the linker, the specificity of an antibody with antigen, and so on, remain a challenge in developing ADCs.
Formation and Flocking Control Algorithms for Robot Networks with Double Integrator Dynamics and Time-Varying Formations
Authors: Montañez-Molina Carlos , Pliego-Jiménez Javier , Martínez-Clark Rigoberto
Published: May 2023

In this work, we study the problem of designing control laws that achieve time-varying formation and flocking behaviors in robot networks where each agent or robot presents double integrator dynamics. To design the control laws, we adopt a hierarchical control approach. First, we introduce a virtual velocity, which is used as a virtual control input for the position subsystem (outer loop). The objective of the virtual velocity is to achieve collective behaviors. Then, we design a velocity tracking control law for the velocity subsystem (inner loop). An advantage of the proposed approach is that the robots do not require the velocity of their neighbors. Additionally, we address the case in which the second state of the system is not available for feedback. We include a set of simulation results to show the performance of the proposed control laws.
Regional Time-Series Coding Network and Multi-View Image Generation Network for Short-Time Gait Recognition
Authors: Sun Wenhao , Lu Guangda , Zhao Zhuangzhuang , Guo Tinghang , Qin Zhuanping , Han Yu
Published: May 2023

Gait recognition is one of the important research directions of biometric authentication technology. However, in practical applications, the original gait data is often short, and a long and complete gait video is required for successful recognition. Also, the gait images from different views have a great influence on the recognition effect. To address the above problems, we designed a gait data generation network for expanding the cross-view image data required for gait recognition, which provides sufficient data input for feature extraction branching with gait silhouette as the criterion. In addition, we propose a gait motion feature extraction network based on regional time-series coding. By independently time-series coding the joint motion data within different regions of the body, and then combining the time-series data features of each region with secondary coding, we obtain the unique motion relationships between regions of the body. Finally, bilinear matrix decomposition pooling is used to fuse spatial silhouette features and motion time-series features to obtain complete gait recognition under shorter time-length video input. We use the OUMVLP-Pose and CASIA-B datasets to validate the silhouette image branching and motion time-series branching, respectively, and employ evaluation metrics such as IS entropy value and Rank-1 accuracy to demonstrate the effectiveness of our design network. Finally, we also collect gait-motion data in the real world and test them in a complete two-branch fusion network. The experimental results show that the network we designed can effectively extract the time-series features of human motion and achieve the expansion of multi-view gait data. The real-world tests also prove that our designed method has good results and feasibility in the problem of gait recognition with short-time video as input data.
Threshold of the CAPB That Can Be Attributed to Fiscal Consolidation Episodes in South Africa
Authors: Buthelezi Eugene Msizi , Nyatanga Phocenah
Published: May 2023

This paper investigates the threshold of the cyclical adjusted primary balance (CAPB) that can be attributed to fiscal consolidation in South Africa. The CAPB framework is used in the threshold autoregressive regime (TAR) from 1979 to 2022. The contribution of the paper is the estimation of the CAPB in the context of South Africa to find fiscal consolidation episodes. Moreover, we identify the threshold of CAPB that can be attributed to fiscal consolidation, which the available literature is silent on. The TAR, first-order derivative and dummy variables are employed to find thresholds that can be attributed to fiscal consolidation episodes. By doing so, we provide valuable insights into the underlying dynamics of fiscal consolidation in the country, which can help policymakers develop more effective strategies for managing fiscal consolidation episodes. We estimated the success of fiscal consolidation on government debt in South Africa. There is a threshold of −1.28168%, 1.9182%, and 1.9270% for the CAPB of total government revenue increase, government expenditure cut, and the CAPB as a sum of both revenue and expenditure, respectively. These thresholds are different from the threshold of 1.5% advocated in the literature. It is recommended that a country-based threshold be used to find fiscal consolidation episodes. No or less fiscal consolidation is needed, as it results in less chance of reduction in government debt. Fiscal authorities must establish and execute a strategy for managing domestic government debt to avoid increasing its risk.