bluuebunny/crossref_metadata_2025 huggingface dataset:
Agricultural Water Productivity-Based Hydro-Economic Modeling for Optimal Crop Pattern and Water Resources Planning in the Zarrine River Basin, Iran, in the Wake of Climate Change
Authors: Emami Farzad , Koch Manfred
Published: October 2018

For water-stressed regions/countries, like Iran, improving the management of agricultural water-use in the wake of climate change and increasingly unsustainable demands is of utmost importance. One step further is then the maximization of the agricultural economic benefits, by properly adjusting the irrigated crop area pattern to optimally use the limited amount of water available. To that avail, a sequential hydro-economic model has been developed and applied to the agriculturally intensively used Zarrine River Basin (ZRB), Iran. In the first step, the surface and groundwater resources, especially, the inflow to the Boukan Dam, as well as the potential crop yields are simulated using the Soil Water Assessment Tool (SWAT) hydrological model, driven by GCM/QM-downscaled climate predictions for three future 21th-century periods under three climate RCPs. While in all nine combinations consistently higher temperatures are predicted, the precipitation pattern are much more versatile, leading to corresponding changes in the future water yields. Using the basin-wide water management tool MODSIM, the SWAT-simulated water available is then optimally distributed across the different irrigation plots in the ZRB, while adhering to various environmental/demand priority constraints. MODSIM is subsequently coupled with CSPSO to optimize (maximize) the agro-economic water productivity (AEWP) of the various crops and, subsequently, the net economic benefit (NEB), using crop areas as decision variables, while respecting various crop cultivation constraints. Adhering to political food security recommendations for the country, three variants of cereal cultivation area constraints are investigated. The results indicate considerably-augmented AEWPs, resulting in a future increase of the annual NEB of ~16% to 37.4 Million USD for the 65%-cereal acreage variant, while, at the same time, the irrigation water required is reduced by ~38%. This NEB-rise is achieved by augmenting the total future crop area in the ZRB by about 47%—indicating some deficit irrigation—wherefore most of this extension will be cultivated by the high AEWP-yielding crops wheat and barley, at the expense of a tremendous reduction of alfalfa acreage. Though presently making up only small base acreages, depending on the future period/RCP, tomato- and, less so, potato- and sugar beet-cultivation areas will also be increased significantly.
An Adaptive Offloading Method for an IoT-Cloud Converged Virtual Machine System Using a Hybrid Deep Neural Network
Authors: Son Yunsik , Jeong Junho , Lee YangSun
Published: October 2018

A virtual machine with a conventional offloading scheme transmits and receives all context information to maintain program consistency during communication between local environments and the cloud server environment. Most overhead costs incurred during offloading are proportional to the size of the context information transmitted over the network. Therefore, the existing context information synchronization structure transmits context information that is not required for job execution when offloading, which increases the overhead costs of transmitting context information in low-performance Internet-of-Things (IoT) devices. In addition, the optimal offloading point should be determined by checking the server’s CPU usage and network quality. In this study, we propose a context management method and estimation method for CPU load using a hybrid deep neural network on a cloud-based offloading service that extracts contexts that require synchronization through static profiling and estimation. The proposed adaptive offloading method reduces network communication overheads and determines the optimal offloading time for low-computing-powered IoT devices and variable server performance. Using experiments, we verify that the proposed learning-based prediction method effectively estimates the CPU load model for IoT devices and can adaptively apply offloading according to the load of the server.
Analysis of Influencing Factors of Big Data Adoption in Chinese Enterprises Using DANP Technique
Authors: Wang Lei , Yang Mengke , Pathan Zulfiqar Hussain , Salam Shafaq , Shahzad Khuram , Zeng Jianqiu
Published: October 2018

Globally, many enterprises are currently focusing on big data technology to improve their performance and operations. Recent literature points out several factors that influence the adoption of big data. However, enterprises often resist using the business value of big data due to a lack of knowledge. The purpose of this study is to investigate the factors influencing big data adoption by Chinese enterprises and to develop an indicator system based on the Motivation–Opportunity–Ability (MOA) model. Moreover, the Decision-Making Trial and Evaluation Laboratory (DEMATEL) method is used to construct a network relationship map and to analyze its effects. Using the DEMATEL-based Analytic Network Process (ANP) (DANP) method to identify the weight distribution of index, this study quantitatively evaluates the influencing factors. The results show that leadership support, perceived usefulness, financial support, data resources, industrial development, data talents, and technical capability are key elements affecting the application of big data. Accordingly, some targeted suggestions are proposed.
Accessibility Changes: Analysis of the Integrated Public Transport System of Bogotá
Authors: Guzman Luis A. , Oviedo Daniel , Cardona Rafael
Published: October 2018

Bogotá, a paradigmatic case of urban (re)development driven by transport interventions, began transforming its public transport system anew in mid-2010. It was not until 2012 when a gradual implementation of the new integrated public transport system of Bogotá (SITP in Spanish) began. By 2015, about 74% of the new bus routes were implemented. The considerable changes in supply and operational models for public transport during this period redefined travel conditions, having a direct impact on accessibility. Our research analyzes observable changes in accessibility to jobs and houses at both the home and work ends of trips as a result of differences in travel time for respondents to a household travel survey in Bogotá between 2011 and 2015. The paper presents a cross-sectional analysis of accessibility changes, pinpointing low accessibility levels facilitated by the current public transport system to the most deprived groups of Bogotá. Results are presented as access curves by socioeconomic levels and zones that estimate the time required to access workplaces via public transport. Results show that the location of low-income settlements implies a disadvantage as a consequence of spatial segregation that increases distances to job-opportunities. Five years after the implementation of the SITP, public transport in Bogotá still fails to improve accessibility, reinforcing gaps between rich and poor groups instead of closing them.
Indicators on the Impacts of Climate Change on Biodiversity in Germany—Data Driven or Meeting Political Needs?
Authors: Schliep Rainer , Walz Ulrich , Sukopp Ulrich , Heiland Stefan
Published: October 2018

When developing new indicators for policy advice, two different approaches exist and may be combined with each other. First, a data-driven, bottom-up approach determines indicators primarily by the availability of suitable data. Second, indicators can be developed by a top-down approach, on the basis of political fields of action and related normative goals. While the bottom-up approach might not meet the needs of an up-to-date policy advice, the top-down approach might lack the necessary data. To discuss these problems and possible solutions, we refer to the ongoing development of an indicator system on impacts of climate change on biodiversity in Germany, where a combination of both approaches has been successfully applied. We describe suitable indicators of this system and discuss the reasons for the remaining gaps. Both approaches, mentioned above, have advantages, constraints, and shortcomings. The scientific accuracy of the indicators, the availability of data and the purpose of policy advice have to be well-balanced while developing such indicator systems.
Integration of 3D Printing and Industry 4.0 into Engineering Teaching
Authors: Chong Siewhui , Pan Guan-Ting , Chin Jitkai , Show Pau Loke , Yang Thomas Chung Kuang , Huang Chao-Ming
Published: October 2018

The rapid emergence of Industry 4.0 implies that our engineering graduates need to acquire new competences to adapt to the digital transformation. This paper evaluates the benefits of integrating 3D printing and Industry 4.0 into engineering undergraduate programs. Surveys were conducted to gather the feedbacks and views from academics and students. 75% and 86% of the participating students and lecturers, respectively, have heard about Industry 4.0. 63% of the students were exposed to modules with such elements. Tangible 3D-printed models enable visualization of fundamental theories and concepts. Enhanced 3D drawing skills and rapid 3D-printed prototypes can greatly help students study common processing equipment, manufacturing, maintenance, logistics, and operations. Some limitations were identified such as budgeting, lack of knowledge, and difficulty in changing from traditional pedagogy. This paper thus proposes a blended learning model for integrating Industry 4.0 into engineering teaching, which consists of traditional, online learning, and flipped classroom approaches. Implementation of the model can be started off with cross-multidisciplinary collaborations or expert-led training for the instructors, followed by traditional face-to-face teaching and online learning. Flipped classroom is one of the essential components of the model which encourages learning-by-making approaches such as ‘bring your own device’ and ‘do it yourself’. Integrating Industry 4.0 into engineering teaching can create a student-based learning environment, where students are gradually trained to become proactive and lifelong learners who are more conscious of the environment and economy.
Interlinked Sustainability Aspects of Low-Rise Residential Family House Development in Slovakia
Authors: Vilčeková Silvia , Selecká Iveta , Burdová Eva Krídlová , Mečiarová Ľudmila
Published: October 2018

This paper compares the sustainability aspects of three family houses according to the Slovak building environmental assessment system (BEAS). Various categories of family houses were evaluated, including site selection, project planning, building construction, indoor environment, energy performance, and water and waste management. Based on the results, Family Houses 3 and 2 are certified as BEAS SILVER, with scores of 2.46 and 2.01, respectively. Family House 1 is certified as BEAS BRONZE, with an overall score of 1.44. The results show, not only the importance of the site in terms of availability, connectivity to the network and the potential to use renewable energy sources, but also the importance of the design and construction of the building, including the application of environmentally friendly building materials, ensuring the quality of the indoor environment and the energy efficiency of the building. The aims of this study were to highlight the current trend in the design and construction of low-rise residential family houses in Slovakia and to identify gaps in the design and construction of key sustainability aspects through the existing building environmental assessment system. In the future, many low-rise residential family houses will be assessed to modify and validate BEAS.
Equipment Maintenance Business Model Innovation for Sustainable Competitive Advantage in the Digitalization Context: Connotation, Types, and Measuring
Authors: Chen Juhong , Zhang Ruijun , Wu Di
Published: October 2018

The equipment maintenance services have become a new profit center and an important way to gain sustainable competitive advantage for manufacturing enterprises. The business model is an important tool for manufacturing enterprises to derive economic benefits from sustainable competitive advantage in the context of digitalization technologies, such as IoT, big data, and cloud computing. At present, the concept of equipment maintenance business model innovation is still vague, and it is rare to report on the innovation behaviors and types of equipment maintenance business models adopted by manufacturing enterprises. Based on literature analysis of equipment maintenance services and business model innovation, following business model gestalt theory, the concept of equipment maintenance business model innovation is analyzed at the business-level, the types are divided into novel and efficient following value sources—“innovation and efficiency”. The initial scale is developed through literature investigation, semi-structured interviews and expert reviews, and tested by exploratory and confirmatory factor analysis by using the data of two independent large-sample questionnaires. The results indicate that the behavior and types of equipment maintenance business model innovation can be described by two types and 19 items.
Impact of Construction IT Technology Convergence Innovation on Business Performance
Authors: Kim Dae Geon , Choi Sang Ok
Published: October 2018

As the era of the fourth Industrial revolution begins, there is high demand for new information technology (IT) innovation to address the challenges of a dramatically changing industrial landscape. The construction industry, which is one the most important traditional industries in Korea, has adopted new IT innovation in their products to meet customer demand, regulation from government, energy efficiency, security, and so on. The aim of our study is to empirically clarify the impact of technology innovation on the business performance for Korean domestic construction conglomerates. The study performs an empirical analysis with time series analysis on business performance from the perspective of client satisfaction with the services the target companies provide and the production process improvement, as well as from a financial perspective. As analysis data, statistical data from the Ministry of Science, ICT, and Future Planning; Brand Stock; Bank of Korea; and each company are utilized, and the target companies for our study are limited to 19 construction companies with an apartment brand. Multiple regression analysis is used as a fundamental analysis methodology of our study. For Time Series Analysis, the Box Jenkins Model, namely, ARIMA is utilized. According to our results, it is found that any improvement of IT convergence innovation competence such as business efficiency IT index, collaboration IT index, and strategy management IT index has a positive impact on the production process, financial performance, and customer satisfaction with the services the companies provide.
‘Āina Kaumaha: The Maintenance of Ancestral Principles for 21st Century Indigenous Resource Management
Authors: Kurashima Natalie , Jeremiah Jason , Whitehead A. Nāmaka , Tulchin Jon , Browning Mililani , Duarte Trever
Published: October 2018

Globally, there is growing recongition of the essential role indigneous people have in biocultural conservation. However, there are few cases of applied indigenous resource management today, especially from the indigenous standpoint. In this paper, we provide an example of the maintenance and adaptation of an indigenous resource management system in Hawai‘i from the perspective of an instrumental ‘Ōiwi (Indigenous Hawaiian) social institution, Kamehameha Schools. Kamehameha Schools is not only the largest private landowner in Hawai‘i, but is uniquely tied to a lineage of traditional ali‘i (chiefs) resulting in present-day influence, decision-making authority, and wealth to fund a perpetual vision for its ancestral lands and communities. Notably, we share our journey from the perspective of indigenous resource managers, using the ‘Ōiwi methodology of mo‘okū‘auhau (genealogy and continuity) to guide our (re)discovery of what it means to steward in an indigenous way. First, we ground ourselves in ‘Ōiwi worldviews, recognizing our genealogical and reciprocal connections to ‘āina (land and sea). Then, we examine the functions of the traditional institution of the ali‘i and the chiefly principle of ‘āina kaumaha—a heavy obligation to steward the biocultural health of lands and seas in perpetuity. We detail how ‘āina kaumaha has manifested and transferred over generations, from traditional ali‘i to the royal Kamehameha line, to Kamehameha Schools as an ali‘i institution. Finally, we discuss how we endeavor to meet inherited obligations through Kamehameha Schools’ resource management approach today, which includes active stewardship of vast tracts of native ecosystems and Hawai‘i’s most important cultural sites, influencing biocultural well-being through representing ‘Ōiwi perspectives in diverse industries, and developing the next generation of ‘Ōiwi stewards. We provide a guide for indigenous organizations (re)defining their ancestral ways of stewardship, as well as for the many non-indigenous agencies with obligations to native lands and people today working to incorporate indigenous systems into their current management. Given that much of the world’s lands are indigenous spaces, we argue that the restoration of effective biocultural resource management systems worldwide requires the maintenance, and in some cases reestablishment, of indigenous institutions at multiple levels.
How Green Building Product Decisions from Customers Can Be Transitioned to Manufacturers: An Agent-Based Model
Authors: Meng Qingfeng , Zhu Hongming , Li Zhen , Du Jianguo , Wang Xiangyu , Jeong Kim Mi
Published: October 2018

The development of green building products is of great significance to the sustainability of construction projects. Both the financial ability and adoption behavior of customers have a great influence on the decisions made by manufacturers regarding the development of green building products. To clarify how customer behavior related to green building products can be transitioned to manufacturers, this paper presents a multiagent model that considers the interactions between customers and manufacturers, describing the decision process of manufacturers through the swarm intelligence algorithm and taking complex characteristics of agents into account. Results show that the customer’s financial ability has a positive impact on the green decisions of manufactures. In addition, the average greenness of products produced by manufacturers is found to be lower than that required by customers. Furthermore, building products within a certain range of greenness has strategic advantages in market competition, leading to higher sales and a monopoly position.
Experimental Study of Thermal and Catalytic Pyrolysis of Plastic Waste Components
Authors: Anene Azubuike Francis , Fredriksen Siw Bodil , Sætre Kai Arne , Tokheim Lars-Andre
Published: October 2018

Thermal and catalytic pyrolysis of virgin low-density polyethylene (LDPE), high-density polyethylene (HDPE), polypropylene (PP) and mixtures of LDPE/PP were carried out in a 200 mL laboratory scale batch reactor at 460 °C in a nitrogen atmosphere. Thermogravimetric analysis (TGA) was carried out to study the thermal and catalytic degradation of the polymers at a heating rate of 10 °C/min. The amount of PP was varied in the LDPE/PP mixture to explore its effect on the reaction. In thermal degradation (TGA) of LDPE/PP blends, a lower decomposition temperature was observed for LDPE/PP mixtures compared to pure LDPE, indicating interaction between the two polymer types. In the presence of a catalyst (CAT-2), the degradation temperatures for the pure polymers were reduced. The TGA results were validated in a batch reactor using PP and LDPE, respectively. The result from thermal pyrolysis showed that the oil product contained significant amounts of hydrocarbons in the ranges of C7–C12 (gasoline range) and C13–C20 (diesel range). The catalyst enhanced cracking at lower temperatures and narrowed the hydrocarbon distribution in the oil towards the lower molecular weight range (C7–C12). The result suggests that the oil produced from catalytic pyrolysis of waste plastics has a potential as an alternative fuel.
Exploring Driving Forces of Innovation in the MSEs: The Case of the Sustainable B&B Tourism Industry
Authors: Liu Chia-Wei , Cheng Jen-Son
Published: October 2018

The purpose of this study is to explore the driving forces of innovation in micro and small enterprises (MSEs) in the tourism industry and to understand how these drivers help allocate and utilize resources, thereby increasing innovations’ success and sustainable development. This study focused on Taiwan’s bed and breakfast (B&B) industry. In-depth interviews were conducted with the owners of 20 B&Bs that displayed innovation activities and were selected following a strict evaluation procedure. A content analysis was then performed to obtain the seven driving forces of innovation: B&B owners’ lifestyles, customers, market information, external knowledge, business expansion needs, policy, and familiar partners. The results show that the B&B owners’ lifestyles and customers are key drivers of innovation. On the other hand, employees, family and friends are less frequently mentioned. Our results can serve as a reference for innovation in both the B&B industry and MSEs.
Let There Be Light! Investigating Vernacular Daylighting in Moroccan Heritage Hammams for Rehabilitation, Benchmarking and Energy Saving
Authors: Sibley Magda
Published: October 2018

This paper provides the first study of vernacular daylighting provision in Moroccan heritage public bathhouses in order to rehabilitate it for experiential authenticity, energy saving and improved users’ well-being. The analysis of a representative sample of 13 still working hammams reveals recurrent patterns of oculi numbers and configurations. These consist of one to three rows of eight circular roof openings (oculi) of 18 to 20 cm diameter, arranged along the roof vault of each bathing space. The ratio of total roof openings’ area to internal floor area rarely exceeds 2%. Synchronised measurements of horizontal illuminance on the roof and inside the bathing spaces in a case study hammam were conducted in July and August 2016, after rehabilitating all roof oculi. Recorded levels indicated that maximum horizontal illuminance never exceeds 60 lx. The calculation and plotting of daylight factor based on real data reveal levels under 2% and a sudden decline in the hot room early afternoon due to steam accumulation. The paper provides the first benchmark of vernacular daylight rehabilitation in Moroccan heritage hammams and the illuminance it affords. It introduces an innovative combination of historical, architectural and building science methodologies that can be extended to other heritage building types.
Sustainable Activity of Cultural Service Consumers of Social Media Users—Influence on the Brand Capital of Cultural Institutions
Authors: Wróblewski Łukasz , Bilińska-Reformat Katarzyna , Grzesiak Mateusz
Published: October 2018

In the second decade of the 21st century, social media changed the nature of communication and cooperation between participants of the culture services market. They became, among other things, an important marketing instrument in the area of contact with the customers of the cultural offer. However, despite their growing importance in various areas of activity of organisations in the cultural sector, the issue of building the cultural institution’s brand equity by social media users is relatively seldom raised. Research on the impact of online consumer activity on brand equity is at an early stage of development. Therefore, this article is an attempt to fill the research gap in this area. The article presents the results of a survey that was conducted in 2018 on a group of 1021 consumers of cultural services, who at the same time regularly used social media. The statistical analysis carried out and the research results obtained prove that the 3C sustainable system (3C means: consumer Consumption, Contribution, Creation) developed by the authors, concerning the activity of consumers of cultural services in social media, stimulates the consumer-based brand equity (CBBE). Statistically significant relations have been observed in particular for CBBE components that are related to the awareness of a cultural institution’s brand and for the relationship related to the perception of its quality.
Streptomyces roseolus, A Promising Biocontrol Agent Against Aspergillus flavus, the Main Aflatoxin B1 Producer
Authors: Caceres Isaura , Snini Selma P. , Puel Olivier , Mathieu Florence
Published: October 2018

Crop contamination by aflatoxin B1 is a current problem in tropical and subtropical regions. In the future, this contamination risk may be expanded to European countries due to climate change. The development of alternative strategies to prevent mycotoxin contamination that further contribute to the substitution of phytopharmaceutical products are thus needed. For this, a promising method resides in the use of biocontrol agents. Several actinobacteria strains have demonstrated to effectively reduce the aflatoxin B1 concentration. Nevertheless, the molecular mechanism of action by which these biological agents reduce the mycotoxin concentration has not been determined. The aim of the present study was to test the potential use of Streptomyces roseolus as a biocontrol agent against aflatoxin B1 contamination. Co-cultures with Aspergillus flavus were conducted, and the molecular fungal response was investigated through analyzing the q-PCR expression of 65 genes encoding relevant fungal functions. Moreover, kojic and cyclopiazonic acid concentrations, as well as morphological fungal changes were also analyzed. The results demonstrated that reduced concentrations of aflatoxin B1 and kojic acid were respectively correlated with the down-regulation of the aflatoxin B1 gene cluster and kojR gene expression. Moreover, a fungal hypersporulated phenotype and a general over-expression of genes involved in fungal development were observed in the co-culture condition.
Diarrhetic Shellfish Toxin Monitoring in Commercial Wild Harvest Bivalve Shellfish in New South Wales, Australia
Authors: Farrell Hazel , Ajani Penelope , Murray Shauna , Baker Phil , Webster Grant , Brett Steve , Zammit Anthony
Published: October 2018

An end-product market survey on biotoxins in commercial wild harvest shellfish (Plebidonax deltoides, Katelysia spp., Anadara granosa, Notocallista kingii) during three harvest seasons (2015–2017) from the coast of New South Wales, Australia found 99.38% of samples were within regulatory limits. Diarrhetic shellfish toxins (DSTs) were present in 34.27% of 321 samples but only in pipis (P. deltoides), with two samples above the regulatory limit. Comparison of these market survey data to samples (phytoplankton in water and biotoxins in shellfish tissue) collected during the same period at wild harvest beaches demonstrated that, while elevated concentrations of Dinophysis were detected, a lag in detecting bloom events on two occasions meant that wild harvest shellfish with DSTs above the regulatory limit entered the marketplace. Concurrently, data (phytoplankton and biotoxin) from Sydney rock oyster (Saccostrea glomerata) harvest areas in estuaries adjacent to wild harvest beaches impacted by DSTs frequently showed elevated Dinophysis concentrations, but DSTs were not detected in oyster samples. These results highlighted a need for distinct management strategies for different shellfish species, particularly during Dinophysis bloom events. DSTs above the regulatory limit in pipis sampled from the marketplace suggested there is merit in looking at options to strengthen the current wild harvest biotoxin management strategies.
The Protective Role of Bacillus velezensis A2 on the Biochemical and Hepatic Toxicity of Zearalenone in Mice
Authors: Wang Nan , Li Peng , Wang Mingyang , Chen Si , Huang Sheng , Long Miao , Yang Shuhua , He Jianbin
Published: October 2018

Zearalenone (ZEN) is an estrogen-like mycotoxin produced by Fusarium that seriously compromises the safety of animal and human health. In this study, our aim was to evaluate the protective effect of Bacillus velezensis A2 against biochemical and pathological changes induced by zearalenone in mice. Kunming mice (n = 40; 25 ± 2 g) were allotted to four treatment groups: a control group (basic feed); a ZEN group (basic feed with a ZEN dose of 60 mg/kg); an A2 strain fermented feed group (150 g of feed mixed with 150 mL of sterile distilled water and inoculated with 5 mL of phosphate buffer salt (PBS) resuspended A2 strain); and an A2 strain fermented ZEN-contaminated feed group. (A2 strain group 150 mL pure bacterial distilled water system mixed with 150 g ZEN-contaminated feed.) Our results showed that the Bacillus velezensis A2 strain can completely degrade the ZEN-contaminated feed within 5 days. (The concentration of ZEN in fermentation was 60 μg/mL.) After the mice fed for 28 days, compared with the control group, the activities of AST and ALT were increased, the activities of glutathione peroxidase (GSH-PX) and total superoxide dismutase (T-SOD) were decreased, and the amount of creatinine (CRE), blood urea nitrogen (BUN), uric acid (UA), and malondialdehyde (MDA) in the ZEN group were increased in the mice serum (p < 0.05; p < 0.01). However, compared with the ZEN group, these biochemical levels were reversed in the A2 strain fermented feed group and in the A2 strain fermented ZEN-contaminated feed group (p < 0.05; p < 0.01). Furthermore, histopathological analysis only showed pathological changes of the mice liver in the ZEN group. The results showed that Bacillus velezensis A2 as additive could effectively remove ZEN contamination in the feed and protect the mice against the toxic damage of ZEN. In conclusion, Bacillus velezensis A2 has great potential use as a microbial feed additive to detoxify the toxicity of zearalenone in production practice.
Silvestrol Inhibits Chikungunya Virus Replication
Authors: Henss Lisa , Scholz Tatjana , Grünweller Arnold , Schnierle Barbara S.
Published: October 2018

Silvestrol, a natural compound that is isolated from plants of the genus Aglaia, is a specific inhibitor of the RNA helicase eIF4A, which unwinds RNA secondary structures in 5′-untranslated regions (UTRs) of mRNAs and allows translation. Silvestrol has a broad antiviral activity against multiple RNA virus families. Here, we show that silvestrol inhibits the replication of chikungunya virus (CHIKV), a positive single-stranded RNA virus. Silvestrol delayed the protein synthesis of non-structural (nsPs) and structural proteins, resulting in a delayed innate response to CHIKV infection. Interferon-α induced STAT1 phosphorylation was not inhibited nor did eIF2α become phosphorylated 16 h post infection in the presence of silvestrol. In addition, the host protein shut-off induced by CHIKV infection was decreased in silvestrol-treated cells. Silvestrol acts by limiting the amount of nsPs, and thereby reducing CHIKV RNA replication. From our results, we propose that inhibition of the host helicase eIF4A might have potential as a therapeutic strategy to treat CHIKV infections.
Research Models and Tools for the Identification of Antivirals and Therapeutics against Zika Virus Infection
Authors: Alves Marco P. , Vielle Nathalie J. , Thiel Volker , Pfaender Stephanie
Published: October 2018

Zika virus recently re-emerged and caused global outbreaks mainly in Central Africa, Southeast Asia, the Pacific Islands and in Central and South America. Even though there is a declining trend, the virus continues to spread throughout different geographical regions of the world. Since its re-emergence in 2015, massive advances have been made regarding our understanding of clinical manifestations, epidemiology, genetic diversity, genomic structure and potential therapeutic intervention strategies. Nevertheless, treatment remains a challenge as there is no licensed effective therapy available. This review focuses on the recent advances regarding research models, as well as available experimental tools that can be used for the identification and characterization of potential antiviral targets and therapeutic intervention strategies.
Impact of Two Reoviruses and Their Coinfection on the Rice RNAi System and vsiRNA Production
Authors: Li Zhanbiao , Zhang Tong , Huang Xiuqin , Zhou Guohui
Published: October 2018

Both Southern rice black-streaked dwarf virus (SRBSDV) and Rice ragged stunt virus (RRSV) belong to the family Reoviridae, and synergistic infection of these two viruses commonly occurs in the field. This study revealed that both SRBSDV and RRSV affect the RNA interference (RNAi) pathway and form different virus-derived interfering RNA (vsiRNA) profiles in rice. Co-infection of rice by SRBSDV and RRSV up-regulated the expression of rice DICER-like (DCL) proteins but down-regulated the expression of rice RNA-dependent RNA polymerases (RDRs), and the accumulation of vsiRNAs of either RBSDV or RRSV was decreased compared with that in singly infected plants. The majority of SRBSDV vsiRNAs were 21 nt or 22 nt in length, whether plants were singly infected with SRBSDV or co-infected with RRSV. On the other hand, the majority of RRSV vsiRNAs were 20 nt, 21 nt, or 22 nt in length, among which those 20 nt in length accounted for the largest proportion; co-infection with SRBSDV further increased the proportion of 20 nt vsiRNAs and decreased the proportion of 21 nt vsiRNAs. Co-infection had no effects on the strand favoritism and hot spots of the vsiRNAs, but changed the bias of the 5′ terminal nucleotide significantly. This study provides a reference for further study on the pathogenesis and synergistic mechanism of SRBSDV and RRSV.
Animal Models of Zika Virus Infection during Pregnancy
Authors: Caine Elizabeth A. , Jagger Brett W. , Diamond Michael S.
Published: October 2018

Zika virus (ZIKV) emerged suddenly in the Americas in 2015 and was associated with a widespread outbreak of microcephaly and other severe congenital abnormalities in infants born to mothers infected during pregnancy. Vertical transmission of ZIKV in humans was confirmed when viral RNA was detected in fetal and placental tissues, and this outcome has been recapitulated experimentally in animals. Unlike other flaviviruses, ZIKV is both arthropod- and sexually-transmitted, and has a broad tissue tropism in humans, including multiple tissues of the reproductive tract. The threats posed by ZIKV have prompted the development of multiple in vivo models to better understand the pathogenesis of ZIKV, particularly during pregnancy. Here, we review the progress on animal models of ZIKV infection during pregnancy. These studies have generated a foundation of insights into the biology of ZIKV, and provide a means for evaluating vaccines and therapeutics.
EBV and KSHV Infection Dysregulates Autophagy to Optimize Viral Replication, Prevent Immune Recognition and Promote Tumorigenesis
Authors: Cirone Mara
Published: October 2018

Autophagy is a catabolic process strongly involved in the immune response, and its dysregulation contributes to the onset of several diseases including cancer. The human oncogenic gammaherpesviruses, Epstein—Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV), manipulate autophagy, either during the de novo infection or during the lytic reactivation, in naturally latently-infected lymphoma cells. In particular, the gammaherpesvirus infection reduces autophagy in immune cells, such as monocytes, resulting in the impairment of cell survival and cell differentiation into dendritic cells (DCs), which are essential for initiating and regulating the immune response. In the case of EBV, the reduction of autophagy in these cells, leading to p62 accumulation, activated the p62-NRF2-antioxidant response, reducing ROS, and further inhibiting autophagy. KSHV inhibits autophagy in monocytes by de-phosphorylating JNK2, altering the calpains–calpastatin balance and increasing the calpain activity responsible for the cleavage of ATG5. To further impair the immune response, KSHV also inhibits autophagy in differentiated DCs by hyper-phosphorylating STAT3. Conversely, when the lytic cycle is induced in vitro in latently-infected lymphoma B cells, both EBV and KSHV promote autophagy to enhance their replication, although the final autophagic steps are blocked through the down-regulation of Rab7. This strategy allows viruses to avoid the destructive environment of lysosomes, and to exploit the autophagic machinery for intracellular transportation. EBV and KSHV encode for proteins that may either inhibit or promote autophagy and, in addition, they can modulate the cellular pathways that control this process. In this review we will discuss the findings that indicate that autophagy is dysregulated by gammaherpesvirus to promote immune suppression, facilitate viral replication and contribute to the onset and maintenance of gammaherpesvirus-associated malignancies.
A Bi-Objective Pseudo-Interval T2 Linear Programming Approach and Its Application to Water Resources Management Under Uncertainty
Authors: Jin Lei , Fu Haiyan , Kim Younggy , Long Jiangxue , Huang Guohe
Published: October 2018

In realistic water resource planning, fuzzy constraints can be violated but still allowed to certain acceptance degrees. To address this issue, in this study, a bi-objective pseudo-interval type 2 (T2) linear programming approach with a ranking order relation between the intervals is proposed for water system allocation. This developed approach can transform normal T2 fuzzy sets, including both trapezoidal and triangular types, into the bi-objective linear programming approach solved with the proposed algorithm with mathematical rigor, which improves the flexibility of the decision supports. The new model is applied in the utilization of regional water resource management in Xiamen city, China. Concurrently, a local water system model is established by considering the aspects of industrial, agricultural, and municipal requirements. Thus, by analysis of the solution algorithm, decision-makers can obtain different optimal results by selecting different acceptance degrees. The results also demonstrate the superiority of the proposed method. Therefore, this approach not only augments the theory of the optimal allocation method in water resource management, but also provides the support for meeting the requirements of the 13th five-year plan for Xiamen ecological planning.
Multi-Criteria Evaluation for China Low-Impact Development Based on Principal Component Analysis
Authors: Li Nan , Xie Lina , Du Pengfei , Huang Xiaochan
Published: October 2018

Multiple benefit evaluation may become complicated due to varied and unquantifiable indicators. This study presents a multicriteria approach to evaluate Low Impact Development (LID) performance through an aggregation of principal component analysis and correlation analysis (PCCA). The approach is based on the rule of triple bottom line and complies with the China-specific planning land-use type and site-specific hydrologic and hydrologic condition. The quantitative indicators are coupled with the Stormwater Management Model (SWMM) software and filed investigation; the qualitative indicators are valued by a numerical unit system that converts the level of importance to numbers 5, 4, 3, 2 and 1. The results indicate that the PCCA approach could evaluate the LID performance with fewer dimensions of variables based on environmental, economic and social concerns comprehensively. The principal components concentrated on three streams: (1) runoff quantity and quality control; (2) minimize cost and improve robustness; and (3) improve system management and aesthetic enhancement. Taken together, these streams match the objective of sponge city construction with LID techniques. The PCCA approach is a multicriteria decision-aid tool that helps the decision maker choose the appropriate LID technique.
Improved Process Representation in the Simulation of the Hydrology of a Meso-Scale Semi-Arid Catchment
Authors: Saraiva Okello Aline M. L. , Masih Ilyas , Uhlenbrook Stefan , Jewitt Graham P. W. , Van der Zaag Pieter
Published: October 2018

The variability of rainfall and climate, combined with land use and land cover changes, and variation in geology and soils makes it a difficult task to accurately describe the key hydrological processes in a catchment. With the aim to better understand the key hydrological processes and runoff generation mechanisms in the semi-arid meso-scale Kaap catchment in South Africa, a hydrological model was developed using the open source STREAM model. Dominant runoff processes were mapped using a simplified Height Above the Nearest Drainage approach combined with geology. The Prediction in Ungauged Basins (PUB) framework of runoff signatures was used to analyse the model results. Results show that in the headwater sub-catchments of Noordkaap and Suidkaap, plateaus dominate, associated with slow flow processes. Therefore, these catchments have high baseflow components and are likely the main recharge zone for regional groundwater in the Kaap. In the Queens sub-catchment, hillslopes associated with intermediate and fast flow processes dominate. However, this catchment still has a strong baseflow component, but it seems to be more impacted by evaporation depletion, due to different soils and geology, especially in drier years. At the Kaap outlet, the model indicates that hillslopes are important, with intermediate and fast flow processes dominating and most runoff being generated through direct runoff and shallow groundwater components, particularly in wetter months and years. There is a high impact of water abstractions and evaporation during the dry season, affecting low flows in the catchment. Results also indicate that the root zone storage and the parameters of effective rainfall separation (between unsaturated and saturated zone), quickflow coefficient and capillary rise, were very sensitive in the model. The inclusion of capillary rise (feedback from the saturated to unsaturated zone) greatly improved the simulation results.
Numerical and Experimental Comparative Study on the Flow-Induced Vibration of a Plane Gate
Authors: Shen Chunying , Wang Wei , He Shihua , Xu Yimin
Published: October 2018

A numerical method is applied here to simulate the unstable flow and the vibration of a plane gate. A combination of the large eddy simulation (LES) method and the volume of fluid (VOF) model is used to predict the three-dimensional flow field in the vicinity of a plane gate with submerged discharge. The water surface profile, the streamline diagrams, the distribution of turbulent kinetic energy, the power spectrum density curve of the fluctuating pressure coefficient at typical points underneath the gate, and the complete vortex distribution around the gate are obtained by LES-VOF numerical calculation. The vibration parameters of the gate are calculated by the fluid-structure coupling interface transferring the hydrodynamic load. A simultaneous sampling experiment is performed to verify the validity of the algorithm. The calculated results are then compared with experimental data. The difference between the two is acceptable and the conclusions are consistent. In addition, the influence of the vortex in the slot on the flow field and the vibration of the gate are investigated. It is feasible to replace the experiment with the fluid-structure coupling computational method, which is useful for studying the flow-induced vibration mechanism of plane gates.
Analyzing Changes in the Flow Regime of the Yangtze River Using the Eco-Flow Metrics and IHA Metrics
Authors: Gao Bing , Li Jie , Wang Xiaoshu
Published: October 2018

Changes in the flow regime of the Yangtze River were investigated using an efficient framework that combined the eco-flow metrics (ecosurplus and ecodeficit) and Indicators of Hydrologic Alteration (IHA) metrics. A distributed hydrological model was used to simulate the natural flow regime and quantitatively separate the impacts of reservoir operation and climate variation on flow regime changes. The results showed that the flow regime changed significantly between the pre-dam and post-dam periods in the main channel and major tributaries. Autumn streamflow significantly decreased in the main channel and in the tributaries of the upper Yangtze River, as a result of a precipitation decrease and reservoir water storage. The release of water from reservoirs to support flood regulation resulted in a significant increase in winter streamflow in the main channel and in the Minjiang, Wujiang, and Hanjiang tributaries. Reservoir operation and climate variation caused a significant reduction in low flow pulse duration in the middle reach of the Yangtze River. Reservoir operation also led to an increase in the frequency of low flow pulses, an increase in the frequency of flow variation and a decrease in the rate of rising flow in most of the tributaries. An earlier annual minimum flow date was detected in the middle and lower reaches of the Yangtze River due to reservoir operation. This study provides a methodology that can be implemented to assess flow regime changes caused by dam construction in other large catchments.
Pain management in acute otitis media: a qualitative study exploring GPs’ views and expectations parallel to a trial of an educational intervention
Authors: van Uum Rick T , Sjoukes Alies , Venekamp Roderick P , Schilder Anne GM , de Groot Esther , Damoiseaux Roger AMJ , Anthierens Sibyl
Published: October 2018

Background

Optimal pain management is accepted as the cornerstone of acute otitis media (AOM) management, but analgesics are neither prescribed routinely nor explicitly recommended in day-to-day practice.

Aim

To explore GPs views on and expectations regarding pain management in children with AOM, and how a multifaceted educational intervention aimed at optimising pain management shapes these perceptions.

Design & setting

Qualitative study conducted alongside a cluster randomised controlled trial (cRCT), the PIMPOM study, in the Netherlands.

Method

Twelve GPs were purposefully sampled from primary care centres allocated to the intervention group and were interviewed, using semi-structured, audio-recorded interviews. The intervention comprised a blended GP educational programme (internet-based and face-to-face training) aimed at discussing pain management proactively with parents using a parent information leaflet, and prescribing paracetamol and ibuprofen according to current guidelines. Interviews were transcribed verbatim and analysed thematically by a multidisciplinary team.

Results

GPs considered AOM a very painful condition. Initially, GPs felt unable to offer adequate treatment for AOM-related ear pain. The intervention provided tools, such as knowledge, communication skills, and an information leaflet, which reduced their feelings of helplessness and empowered them to manage childhood AOM more adequately. GPs indicated that the intervention led to a shift in focus from treating the infection with antibiotics to treating symptoms with analgesics. There was a general lack of knowledge about the possibility of prescribing ibuprofen to children. GPs expressed mixed views on prescribing this drug to children.

Conclusion

A primary-care based multifaceted educational intervention aimed at optimising pain management in childhood AOM offered GPs tools to optimise management of this condition and changed GPs perceptions, namely from treating the infection with antibiotics to treating symptoms.
Propriétés optiques et spectres de diffusion des cristaux d'anthracène
Authors: Colombo L. , Mathieu Jean-Paul
Published: October 2018

Détermination des polarisabilités principales de la molécule d'anthracène. Etude du spectre Raman d'un monocristal. Interprétation du spectre de basse fréquence par la théorie de Kastler et Rousset.