bluuebunny/crossref_metadata_2025 huggingface dataset:
A Method for Real-Time Adaptive Propagation Loss Modeling and Estimation over LOS and NLOS Microcellular Radio Communication Links
Authors: Nwelih Emmanuel
Published: April 2022

Wireless cellular communication technology has developed into a very resourceful commodity worldwide. Today, people of all races can hardly live without means of voice and data cellular communication technology. Imprecise propagation loss estimation leads to high power waste, high co-channel interference and poor service quality in cellular communication system networks. This paper proposes a realistic adaptive fine-tuning method for distinctive propagation loss estimation over a microcellular communication radio links based on signal power measurements from Long Term Evolution radio broadband networks, taking non-line of sight (NLOS) and line of sight (LOS) environments into consideration. The methodology is verified by measurements taken in non-line of sight and line of sight signal propagation scenarios. The results showed that the estimated propagation losses using the proposed realistic adaptive tuning models were more accurate than the existing Cost -231 modelling estimation approach.
Flavonoid Profiles and Antioxidant Potential of Monochoria angustifolia (G. X. Wang) Boonkerd & Tungmunnithum, a New Species from the Genus Monochoria C. Presl
Authors: Tungmunnithum Duangjai , Drouet Samantha , Garros Laurine , Lorenzo Jose Manuel , Hano Christophe
Published: April 2022

Plants of the genus Monochoria have long been utilized in food, cosmetics, and traditional herbal treatment. Thailand has the highest species diversity of this genus and a new member, Monochoria angustifolia (G. X. Wang) Boonkerd & Tungmunnithum has been recently described. This plant is called “Siam Violet Pearl” as a common name or “ไข่มุกสีม่วงแห่งสยาม” as its vernacular name in the same meaning in Thai language. Despite their importance, few researches on Monochoria species have been conducted. This study, thus, provided the results to fill in this gap by: i) determining flavonoids phytochemical profiles of 25 natural populations of M. angustifolia covering the whole floristic regions in Thailand, and ii) determining antioxidant activity using various antioxidant assays to investigate the probable mechanism. The results revealed that M. angustifolia presented a higher flavonoid content than the outgroup, M. hastata. Our results also revealed that flavonoids might be used to investigate Monochoria evolutionary connections and for botanical authentication. The various antioxidant assays revealed that M. angustifolia extracts preferentially act through a hydrogen atom transfer antioxidant mechanism. Pearson correlation analysis indicated significant correlations emphasizing that the antioxidant capacity is most probably the result of a complex phytochemical combinations rather than of a single molecule. Altogether, these results showed that this new species provide an attractive alternative starting material with phytochemical variety and antioxidant potential for the phytopharmaceutical industry.
Statistical Modelling and Experimental Design for the Validation of Droplet Digital PCR Methods
Authors: Uhlig Steffen , Weidner Christopher , Colson Bertrand
Published: April 2022

For the in-house validation of a droplet digital PCR method, a factorial experimental design was implemented. This design serves different purposes. On the one hand, it is an efficient design in relation to the workload involved in achieving a desirable level of reliability of variance estimates. On the other hand, it allows a partitioning of total variance into different components, thus providing information regarding the dominant sources of random variation. The statistical modelling reflects the actual measurement mechanism, establishing relationships between nominal target DNA copies per well, the range of variation of copy numbers per droplet, probability of detection values, and estimated numbers of copies.
Factor Analysis of Time Deposits on Customer Interests at BMT UGT Nusantara Banyuanyar Probolinggo Branch
Authors: Maulana Malik Ibrahim Niroh Qonita Tillah , Alwi Bashori
Published: April 2022

Customer satisfaction is very important in improving the quality or customer confidence in the improvement or development of Islamic financial institutions. This research has a purpose to see what the customers' perceptions of satisfaction with the distribution of ratios obtained from BMT UGT Nusantara Banyuanyar Branch and what factors influence customer interest in deposit products at BMT UGT Nusantara Banyuanyar Probolinggo Branch. The approach taken is a quantitative approach. The measuring instrument selected in this research is the Likert scale. The population used is the customers of BMT UGT Nusantara Banyuanyar Branch. Purposive sampling method is used to take samples. There are three sampling techniques based on characteristics, namely 1) Customers aged over 20 years, 2) Having time deposits, and 3) Having savings deposits for 1 year and over. Questionnaires were distributed to customers of BMT UGT Nusantara Banyuanyar Branch. A total of 53 samples is in line with the provisions of the characteristics of the determination of the sample. Testing the data taken in this research consisted the classical assumption testing (normality test, multicollinearity, and heteroscedasticity) as well hypothesis test (multiple regression analysis). The results of research on profit sharing, location, and social environment good impact on consumer interenst. Meanwhile, promotion and religiosity have no impact on customer interest. These results are said to be in the T test and the result are significantly less than 0.05 and greater than the T table.
Baitul Mal Wat Tamwil Architectural Map: Institutional and Regulatory Analysis
Authors: Saepul Rohman Pupun , Laila Nisful , Shofawati Atina
Published: April 2022

Bait al-maal wa al-tamwiil is a sharia microfinance concept that only exists in Indonesia. There is a uniqueness in the concept, namely the merging of social activities with commercial activities in one institution. This institution was born along with the birth of Islamic banking in Indonesia. This study collects a number of literatures to describe the architectural map of BMT in Indonesia. Currently BMTs mostly operate under Law no. 25 of 1992 concerning Cooperatives and a few others operate under the Financial Services Authority (OJK) through Law no. 1 of 2013 concerning Microfinance Institutions (MFIs). The DSN MUI fatwa which is the basis for the existence of BMT is the DSN-MUI Fatwa No. 141/DSN-MUI/VIII/2021 concerning Guidelines for the Establishment and Operation of Sharia Cooperatives.
Threat of Data Theft (Phishing) Amid Trends in Fintech Users During the Covid-19 Pandemic (Study Phishing In Indonesia)
Authors: Nur Latifah Fitri , Mawardi Imron , Wardhana Bayu
Published: April 2022

The purpose of this research is to find out the extent of the crime of data theft (phishing) in fintech and how to anticipate it in Indonesia in the midst of the Coronavirus Pandemic that has hit Indonesia in recent years. The COVID-19 pandemichas had an impact on all community activities. The existence of social distancing and physical distancing policies has made changes to community activities, including financial services. The use of technology-based financial services or what is often termed financial technology has now become a trend and habit in the community. The literature review research method that we use in this study uses sources from several literacies such as books, journal articles, media reports and so on.The results of this study that phishing is currently found in several models of crimeand there are several efforts to prevent this crime from becoming more widespread.
Why promising drugs are shelved and barriers and facilitators to their re-purposing: A systematic literature review
Authors: Krishnamurthy Nithya , Grimshaw Alyssa A. , Axson Sydney A. , Choe Sung Hee , Miller Jennifer E
Published: April 2022

Background: Repurposing is a drug development strategy receiving heightened attention after the FDA granted emergency use authorization of several repurposed drugs to treat Covid-19. There remain knowledge gaps on facilitators and barriers for repurposing and why promising drug candidates get shelved in the outset. Method: This systematic literature review used controlled vocabulary and free text terms to search ABI/Informa, Academic Search Premier, Business Source Complete, Cochrane Library, EconLit, Google Scholar, Ovid Embase, Ovid Medline, Pubmed, Scopus, and Web of Science Core Collection databases for the characteristics, reasons and example of companies deprioritizing development of promising drugs and barriers, facilitators and examples of successful re-purposing. Results: We identified 11,814 articles, screened 5,976 for relevance, found 437 eligible for full text review, 115 of which were included in full analysis. Most articles (66%, 76/115) discussed why promising drugs are abandoned, with lack of efficacy, or superiority to other therapies, for the studied indication (n=59), strategic business reasons (n=35), safety problems (n=28), research design decisions (n=12), the complex nature of a studied disease or drug (n=7) and regulatory bodies requiring more information (n=2) among the top. Repurposing barriers include inadequate resources (n=42), expertise (n=11), intellectual property challenges (n=26), poor data access (n=20), uncertainty about the value of repurposing (n=13), and liability risks (n=5). Repurposing facilitators include multi-partner collaborations (n=38), access to compound databases and corresponding screening tools (n=32), regulatory modifications (n=5), and tax incentives (n=2).Conclusion: Sponsors deprioritize development of promising drugs due to insufficient efficacy or superiority to other therapies for studied indications or populations, perceived market prospects, and industry consolidation. Inadequate resources and data access and challenges negotiating IP are key barriers needing reform for repurposing to reach its full potential as a core approach in drug development. Multi-partner collaborations and the creation, accessibility, and use of compound databases and tax incentives are key facilitators for repurposing. More research is needed on the current value of repurposing in drug development and how to better facilitate resources to support it, where valuable, especially financial, staffing for out-licensing shelved products, and legal expertise to negotiate IP agreements in multi-partner collaborations.Registration: The protocol was registered on Open Science Framework (https://osf.io/f634k/) as it was not eligible for registration on PROSPERO.
Protocol for a hybrid II study exploring the feasibility of delivering, evaluating, and implementing a self-management programme for people with neuromuscular diseases at a specialist neuromuscular centre (ADAPT-NMD)
Authors: Lee Laurence Edward , Kulnik Stefan Tino , Curran Geoffrey M , Boaz Annette , Ramdharry Gita M
Published: April 2022

Background: Self-management support (SMS) forms a central pillar in the management of many long-term conditions. It is firmly aligned with national health policy but there is a paucity of evidence exploring how it is enacted in the context of neuromuscular diseases (NMDs). Bridges is a SMS programme originally developed in stroke. A new version of the programme (Neuromuscular Bridges) has recently been developed in collaboration with people with lived experience of NMD using co-design methods and requires evaluation. The implementation of SMS is inherently complex with potential barriers at the level of the patient, provider, and wider organisation. The success of implementing programmes can be highly dependent on context, indicating a rationale for considering implementation determinants at an early stage. This study aims to explore the feasibility of delivering and evaluating Neuromuscular Bridges, whilst simultaneously testing the feasibility of an implementation strategy bundle for a specialist neuromuscular centre. Methods:This study employs a hybrid II design underpinned by Normalisation Process Theory (NPT), which has been used prospectively to inform the implementation plan and will be invoked in the analysis. The feasibility of delivering and evaluating Neuromuscular Bridges will be assessed using a single-arm pre-post design. We will explore acceptability, demand within the service, performance of outcome measures, recruitment, and retention. Implementation strategies have been selected from a refined taxonomy of strategies, mapped to NPT, and targeted at known barriers and facilitators at the specialist centre that were identified from preliminary stakeholder engagement activities. The impact of the strategy bundle on fidelity, acceptability, appropriateness, and adoption will be evaluated using qualitative interviews, administrative data, surveys, and a notes audit. ConclusionsThis this study will provide valuable feasibility data on a co-designed SMS programme for people with NMDs and enhance understandings of factors and requirements for delivering, evaluating, and implementing it at a specialist centre. Using hybrid methodology at the feasibility stage is unusual and this study will provide important insights into the usefulness of taking this approach at this point in the research pipeline. Trial registration This trial was registered with ISRCTN. Trial ID: ISRCTN14208138 Date registered: 18/08/2021. Link: https://www.isrctn.com/ISRCTN14208138
Natural Resource Rents, Globalisation and Environmental Degradation: New Insight from 5 Richest African Economies
Authors: Aladejare Samson
Published: April 2022

Environmental degradation has continued to be a major global challenge; hence, it is consistently drawing attention from policymakers and academics. Therefore, this study further contributes to the literature by investigating the contributions of natural resource rents and globalisation to environmental degradation in the 5 richest African economies from 1990 to 2019. Four techniques were applied: the fixed and random effect, feasible generalised least squares and the augmented mean group. The Hausman test was used to affirm the supremacy of the feasible generalised least squares outcomes and, consequently, its use to derive the study inferences. A Dumitrescu and Hurlin causality test was also employed to determine the direction of causality between the subject variables. Findings from the study showed that natural resource rents significantly contribute to environmental degradation. In contrast, globalisation reduces environmental degradation. Urbanisation, which served as a control measure, enhanced environmental sustainability. Robustness checks on the study models revealed the validity and reliability of the models' inferences. The Additional outcomes from the robustness checks revealed that while economic growth has no substantial effect on environmental degradation, human capital development significantly worsens the environment. The study highlights relevant policy actions that could substantially reduce environmental degradation.
Derivation of 1.064 μm albedo on the C-type asteroid Ryugu from laser pulse intensity measurement of the Hayabusa2 LIDAR
Authors: Yamada Ryuhei , Yamamoto Keiko , Oshigami Shoko , Araki Hiroshi , Senshu Hiroki , Noda Hirotomo , Namiki Noriyuki , Matsumoto Koji , Yoshida Fumi , Abe Shinsuke , Hirata Naru , Sasaki Sho , Mizuno Takahide
Published: April 2022

Japanese asteroid explorer Hayabusa2 arrived at C-type asteroid 162173 Ryugu in June 2018. Laser altimeter (LIDAR) onboard Hayabusa2 measured its own transmitted laser pulse intensity and returned pulse intensity from the surface of Ryugu until November 2019. Because the Ryugu surface is extremely rough, topography dominates material property in the conventional derivation of normal albedo. We develop a method to derive the albedo from the rough surface of the C-type asteroid at the LIDAR laser wavelength of 1.064 μm. Using the intensity data obtained before the conjunction of the spacecraft with the Sun, the albedo map covering an equatorial band between – 40˚ and + 20˚ in the latitude is created with 2˚ by 2˚ resolution. The average of the albedo is 0.0406 [[EQUATION]] 0.0031, while about half of them are in the range between 0.04 and 0.045. The low and uniform albedo feature is common to other remote-sensing observations of Ryugu by visible and near-infrared cameras onboard the Hayabusa2.
Supercapsular percutaneously-assisted approach versus conventional posterolateral approach for primary total hip arthroplasty: a prospective randomized controlled trial
Authors: Gan Feng-Ping , Yang Ke-Qin , Zhang Qi-Biao , Lin Xin-Xin , Xie Zhao-Lin , Luo Xiang , Zeng Yi-Rong
Published: April 2022

Background
Supercapsular percutaneously-assisted total hip (SuperPATH) approach has been regarded as as one of minimally invasive and muscle sparing technique, whcih accesses the hip maintaining integrity of the external rotators and capsule.The purpose of this study was to compare the SuperPATH approach with the conventional posterolateral approach in terms of early clinical outcomes and radiological results.
Methods
This prospective randomized controlled single blinded study enrolled patients who underwent unilateral primary THA between March 2018 and December 2019.The demographic data,perioperative status [operative time, incision length, total blood loss, serum marker, and length of hospital stay (LHS)], pain visual analog scale (VAS), and Harris Score (HS) were evaluated and compared between the groups.
Results
Compared with the PLA group, the SuperPATH group had a shorter incision length, lower pain VAS sores within 1 months and better HS within 3 months after operation,the difference was statistically significant(P < 0.05).However, the SuperPATH group had a longer operative time ,more total blood loss,the difference was statistically significant(P < 0.05).The mean complication rate, blood transfusion rate and LHS were similar between two groups(P > 0.05).The VAS and HS were similar between the two groups at 1 year after surgery(P > 0.05). Serum levels of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and creatine kinase(CK) (within 2 weeks postoperatively) were similar between the groups(P > 0.05). The SuperPATH group had a larger acetabular inclination and anteversion(P < 0.05),but it was all within Lewinnek’s safe zone.Leg length discrepancy > 1 cm were more common in the SuperPATH group,but the difference was not significant(P > 0.05).
Conclusion
This study reveals that the SuperPATH technique was associated with lower pain levels, and higher physical function than conventional posterolateral approach .However, it had a longer operative time and more blood loss.
Palliative Care Outpatients in a German Comprehensive Cancer Center - Identifying Indicators for Early and Late Referral
Authors: Mueller Sandy , Fink Madeleine , Hense Joerg , Comino Maria Rosa Salvador , Schuler Martin , Teufel Martin , Tewes Mitra
Published: April 2022

Purpose. Despite that early integration of palliative care is recommended in advanced cancer patients, referrals to specialised palliative care (SPC) frequently occur late. Well-defined referral criteria are still missing. We analysed indicators associated with early (ER) and late referral (LR) to SPC of a high volume outpatient unit of a German comprehensive cancer center.Methods. Characteristics, laboratory parameters and symptom burden of 281 patients at first SPC referral were analysed. Timing of referral was categorized as early, intermediate and late (>12, 3-12 and < 3 months before death). Ordinal logistic regression analysis was used to find factors related to referral timing. Kruskal-Wallis test was used to determine symptom severity and laboratory parameter in each referral category. Results. LRs (50.7%) had worse scores of weakness, loss of appetite, drowsiness, assistance of daily living (all p < 0.001) and organisation of care (p < 0.01) in contrast to ERs. The mean symptom sum score was significantly higher in LRs than ERs (13.03 vs. 16.08; p < 0.01). Parameters indicative of poor prognosis, such as elevated LDH, CRP and neutrophil-to-lymphocyte ratio (NLR) (p < 0.01) as well as the presence of ascites (p < 0.05), were significantly higher (all p < 0.001) in LRs. In univariable analyses, psychological distress (p < 0.05) and female gender (p < 0.05) were independently associated with an ER.Conclusion. A symptom sum score and parameters of poor prognosis like NLR or LDH might be useful to integrate into palliative care screening tools.
Comparison of Primary Radiographic Patterns of Ameloblastoma in Patients with and without Recurrence of Tumor
Authors: Razmara Farnoosh , Aleedawi Zainab Abdulkareem , Mosavat Farzaneh , Kharazifard Mohammad Javad
Published: April 2022

Background: Due to the lack of comprehensive research on the relationship between preliminary radiographs and tumor recurrence, this study was conducted to bring light to the correlation between radiographic findings and ameloblastoma lesion recurrence, surgical method, and jaw reconstruction. Methods: The medical records of 96 patients who were surgically treated for ameloblastoma tumor in Shariati and Sina hospitals in Tehran, over a span of 8 years; 2014-2021, were collected both manually and electronically from the hospitals’ archives. Only 50 patients were included, 27 female and 23 male patients. The mean age of the patients was 36 years (range, 10 to 82 years). Each case has been evaluated and reviewed based on the CBCT Scans and Panoramic radiographs by a specialized oral and maxillofacial radiologist. The patients have been contacted for a follow up to the specialized clinic of maxillofacial surgery of Shariati hospital to assess for a recurrence. Results: Our study revealed that the primary treatment modality (p= 0.051), the primary reconstruction treatment (p=0.007), tumor localization (p= 0.032), primary radiographic patterns (p=0.009), bone expansion (p=0.016) and cortical bone invasion (p=0.029) have a significant association with tumor recurrence. Conclusion: To accomplish accurate results regarding risk factors of ameloblastoma recurrence; a larger number of subjects and studies required, as well as extended long term follow up. We propose to bring the light on which each of primary radiographic patterns, primary treatment modality, primary reconstruction treatment, tumor localization, bone expansion and cortical bone invasion is related to the recurrence of the tumor to be considered during surgical treatment plan and to be collected in one meta-analysis in the future.
Anti-apoptotic effect of adrenomedullin gene delivery on Leydig cells by suppressing TGF-β1 via the Hippo signaling pathway
Authors: Hu Wei , Luo You-wen , Zhu Xia-lian , Li Ming-yong , Zhou Jian-hua , Yang Zhi-min , Tong Tao , Chen Bing-hai , Qin Song-lin , Liu Bo-long
Published: April 2022

To investigate whether adrenomedullin (ADM) rescues the steroidogenic functions of Leydig cells by suppressing transforming growth factor-β1 (TGF-β1) via the Hippo signaling. Primary Leydig cells were treated with lipopolysaccharide (LPS), an adeno-associated virus vector that expressed ADM (Ad-ADM) or sh-RNA of TGF-β1 (Ad-sh-TGF-β1). Cell viability and medium concentrations of testosterone were detected. Gene expression and protein levels were detected for steroidogenic enzymes, TGF-β1, RhoA, YAP, TAZ and TEAD1. Role of Ad-ADM in the regulation of TGF-β1 promoter was confirmed by ChIP and Co-IP. Like Ad-sh-TGF-β1, Ad-ADM reversed the decreased number of Leydig cells and plasma concentrations of testosterone by rescuing the gene and protein levels of SF-1, LRH1, Nur77, StAR, P450scc, 3β-HSD, CYP17 and 17β-HSD. Similar to Ad-sh-TGF-β1, Ad-ADM inhibited the LPS-induced cytotoxicity and cell apoptosis and rescued the gene and protein levels of SF-1, LRH1, Nur77, StAR, P450scc, 3β-HSD, CYP17, 17β-HSD and the medium concentrations of testosterone in LPS-induced Leydig cells. Like Ad-sh-TGF-β1, Ad-ADM ameliorated LPS-induced TGF-β1 expression. In addition, Ad-ADM inhibited RhoA activation, enhanced the phosphorylation of YAP and TAZ, decreased TEAD1 expression which interacted with HDAC5 and then bound to TGF-β1 gene promoter in LPS-exposed Leydig cells. ADM may exert anti-apoptotic effect to rescue the steroidogenic functions of Leydig cells by suppressing TGF-β1 via the Hippo signaling.
ERRα protects against sepsis-induced acute lung injury in rats
Authors: Xia Wenfang , Pan Zhou , Zhang Huanming , Zhou Qingshan , Liu Yu
Published: April 2022

Sepsis-induced acute lung injury (ALI) is associated with poor survival rates. The identification of potential therapeutic targets for preventing sepsis-induced ALI has clinical importance. Here, we show that estrogen-related receptor alpha (ERRα) protects against sepsis-induced ALI through ERRα-mediated apoptosis and autophagy. ERRα was upregulated in inflammation models from lipopolysaccharides (LPS)-treated rat pulmonary microvascular endothelial cells (PMVECs) and cecal ligation and puncture (CLP)-induced septic rats. In vitro , overexpression of ERRα ameliorated LPS-induced degradation of adherens junctional molecules, upregulation of bax, cleaved caspase 3 and cleaved caspase 9 levels and downregulation of anti-apoptotic protein Bcl-2 level, and promoted the formation of autophagic flux, while the knockdown of ERRα exacerbated LPS-induced apoptosis and inhibited the activation of autophagy. Rats injected with ERRα agonist were subjected to CLP to elucidate the role of ERRα in sepsis-induced ALI in vivo . Administration of ERRα agonist alleviated the pathological damage of lung tissue, increased the levels of tight junction proteins and adherens junction proteins, and decreased the expression of apoptosis-related proteins. Promoting the expression of ERRα significantly enhanced the process of autophagy and reduced CLP-induced ALI. Mechanistically, ERRα is essential to regulate the balance between autophagy and apoptosis to maintain the adherens junctional integrity. These findings indicate that activation of ERRα provides a new therapeutic opportunity to prevent sepsis-induced ALI.
Evaluation of the performance of Chilean nursing homes against COVID-19
Authors: Singer Marcos
Published: April 2022

Background: The COVID-19 pandemic hit Chile in March 2020, in the midst of the worst political and social crisis it had suffered in the last 40 years. The causes of the crisis, related to weak social cohesion, were in part the cause of Chile's poor performance in terms of deaths from the pandemic. Unlike the rest of the country, in the case of Chilean nursing homes, three levels of cohesion were achieved: the state, businesses and civil society. We explained in detail how each of these groups provided strategic capabilities that achieved a much higher than expected performance.Methods: Based on information from 18 developed countries and 60 regions (states of the USA, countries of the UK and regions of Spain), we postulated a number of statistical models, quadratic and exponential, to explain deaths in nursing homes as a function of deaths in their geographical area.Results: Knowing that by September 2020, 1,258 elderly people had died, with 95% confidence we deduce that slightly more than 400 were saved. Compared to the 78 countries and regions considered, this makes Chile's nursing homes the fourth best performers.Conclusions: This study demonstrates the importance of social cohesion in facing major challenges such as the battle against COVID-19 in Chile's care homes.
Transplantation of human adipose derived stem cells with co- overexpressed Leukemia inhibitory factor and beta interferon promote recovery in experimental autoimmune encephalomyelitis (EAE)
Authors: Yousefi Mahdieh , Nabipour Abolghasem , Hakemi Mazdak Ganjalikhani , Ashja-Arvan Mehnoosh , Amirpour Noushin , Salehi Hossein
Published: April 2022

Multiple Sclerosis (MS) is the most common demyelinating disease with inflammatory demyelination in central nerve system (CNS). Beside the defect in myelin repair process, the balance change in inflammatory and anti- inflammatory cytokines is one of the most significant factors in MS pathogenesis. This study aimed at evaluating the effects of co-overexpressing beta interferon (IFN-β) and Leukemia inhibitory factor (LIF) in human adipose derived stem cells (IFN-β/LIF-hADSCs) on the experimental autoimmune encephalomyelitis (EAE). 12 days after the induction of EAE on female mice C57Bl/6 with MOG35-55 and the emergence of primary clinical signs, the IFN-β/LIF-hADSCs were injected though the mice tail vein of the EAE mice. The mice were sacrificed after 32 days and the spinal cords of the experimental groups were dissected out for the histopathologic and real time RT-PCR studies. Here, we showed that the clinical scores and infiltration of mononuclear cells of treated mice with IFN-β/LIF-hADSCs were decreased significantly. Remyelination and oligodendrogenesis were significantly increased in the test (IFN-β/LIF-hADSCs) group. The findings revealed that the pattern of inflammatory and anti- inflammatory cytokines gene expression in the IFN-β/LIF-hADSCs group was reversed comparing to control group. Overexpression of LIF as a neurotrophic and IFN-β as an anti-inflammatory cytokine in hADSCs increases the immunomodulatory effect of hADSCs and improves remyelination and oligodendrogenesis in EAE model. This, besides hADSCs capacity for proliferation and differentiation might enhance the treatment efficacy and provide a promising candidate for stem cell-based gene therapy of MS therapy in future.
Boosting ionic conductivity of antiperovskite solid electrolyte by potassium ions substitution for cation clusters
Authors: Gao Lei , Zhang Hao , Han Songbai , Zhu Jinlong , Wang Liping , Li Shuai , Zhao Ruo , Gao Song , Wang Yonggang , Zou Ruqiang , Zhao Yusheng
Published: April 2022

Solid-state electrolytes (SSEs) with high ionic conductivities are crucial for the development of all-solid-state lithium batteries (ASSLBs), and there is a strong correlation between the ionic conductivities and underlying lattice structures of SSEs. Here, we report a novel lattice manipulation method of replacing < Li6OH>+ octahedral clusters with potassium ions in antiperovskite SSEs (Li2OH)0.99K0.01Cl, which leads to its ionic conductivity at room temperature two orders of magnitude higher than that of Li2OHCl. The mechanisms analysis indicates that the novel lattice manipulation method leads to the stabilization of cubic phase and lattice contraction for antiperovskite, and causes significant changes in Li-ion transport paths and migration barriers. Also, the Li | Li symmetric cell and LiFePO4 | Li ASSLB employing (Li2OH)0.99K0.01Cl electrolyte exhibit long-term stable cycling performance, which indicates the application prospects of antiperovskite electrolyte in ASSLBs.
Label-free biocompatible detection and quantification of airborne particulate matter (PM2.5) and chronic tissue injury in heart and lung of mouse
Authors: Hameed Saira , Pan Kun , Su Wenhua , Trupp Miles , Mi Lan , Zhao Jinzhuo
Published: April 2022

While it is known that air borne particulate matter (PM2.5) may pass through the pulmonary circulation of blood at the alveolar level between lung and heart and cross the air-blood barrier, the mechanism and effects are not completely clear. In this study the imaging method fluorescence lifetime imaging microscopy (FLIM) is adopted for visualization with high spatial resolution and quantification of PM particles in mouse lung and heart tissues. The results showed that the median numbers of particles in lung of mice exposed to particulate matter of diameter less than 2.5 µm (PM2.5) was about 2.0 times more than that in the filtered air (FA)-treated mice, and about 1.3 times more in heart of PM2.5-treated mice than in FA-treated mice. Interestingly, PM2.5 particles were more abundant in heart than lung, likely due to how PM particles are cleared by phagocytosis and transport via circulation from lungs. It is proposed that the powerful flow of blood through the heart may contribute to invasion of PM2.5 particles into heart muscles. The histopathological evaluations revealed that exposure of PM2.5 to lungs dilated air spaces and showed signs of inflammation. Moreover, heart tissues showed inflammation and amyloid deposition. The component analysis of concentrated airborne PM2.5 particles suggested traffic exhausts and industrial emissions as predominant sources. Our results strongly suggest association of PM2.5 exposure to chronic lung and heart tissue injuries. The current study supports the contention that industrial air pollution is one of the causative factors for rising levels of chronic pulmonary and cardiac diseases.
A unique case of Central Neurocytoma and Concomitant Brain AVM in a 12- year-old girl with long term follow up and review of the literature.
Authors: Amirjamshidi Abbas , Abbasioun Kazem , Ghasemi Seyyed Babak , Taemeh Darya Goudarzi
Published: April 2022

Central neurocytoma (CNCy) is an exceedingly rare brain tumor occurring mainly within the ventricles in young adults. Anecdotal cases of CNCy occurring simultaneously with other brain lesions have been reported but to the best of our knowledge, no one was accompanied by brain AVM. A 12-year-old girl presented with signs of increased intracranial pressure. A multi-bleb CNCy originated from the septum in the midline, expanding to the lateral and third ventricles, back to the incisura and infratentorial- supra-cerebellar cistern concomitant with a left frontal parafalx AVM. The tumor was removed successfully, and hydrocephalus controlled by ventriculoperitoneal shunting. The AVM bled after 7 years and was extirpated surgically. She is tumor free after 15 years. Presenting the first case of CNCy concomitant with brain AVM in a 12-year-old girl with more than 15 years surgical follow up. Even though we could not find any evidence regarding a genetic problem in our case but “Concomitance of CNCY and AVM” can suggest a congenital origin and a common genetic basis only as a hypothesis.
Optimization of bacterial separation techniques in sepsis for third-generation sequencing
Authors: Lipták Róbert , Tamáš Michal , Strečanský Tomáš , Konečná Barbora , Tóthová Ľubomíra , Hodosy Julius
Published: April 2022

Background:Sepsis is a common serious condition worldwide and diagnostics are still slow. Nanopore sequencing is a promising tool in point of care medicine. However, high ratio of host to bacterial DNA decreases utility of nanopore. Fast, cheap, and easy techniques to separate host from bacterial DNA are required. Aim:The aim was to compare three different separation methods of blood for bacterial DNA enrichment and isolation with subsequent products readily suitable for nanopore sequencing. Methods: Blood was collected from healthy subjects and spiked with either gram-negative or gram-positive bacteria. Three different separation methods alongside negative control were performed. The performance of each method was evaluated by RT-qPCR of 16S gene and B2 microglobulin. Results: 16s RT-qPCR showed similar Ct value for tested methods in comparison to Standard method.However, the host DNA depletion was significantly higher for the centrifugal method compared to others. Reproducibility, based on variability measured by the standard deviation and RT-qPCR results, was highest using the centrifugation method compared to the other three methods. Conclusion: From all tested methods, centrifugation outperformed other basic isolation techniques considering turnaround time, reliability, and effectiveness. Further investigation is needed to confirm our promising results in a real-life scenario.
Spatio-Temporal Analysis of Archived Web News for Precise Political Event Detection and Impact Analysis in India's Southern States
Authors: Muthamizharasan M. , Ponnusamy R.
Published: April 2022

The national political system has the directly impacts the economy. Every political party has their own economic policies. This has the major impact on the economic stability of the nation. Sometimes, few political parties rule either the state or national Governments. Their policies directly reflect in the state or national level financial systems. In general political parties, pay more attention to the state in which they control or aspire to establish their party's rule. Political discourse has an unspoken impact on the state's financial stability. Data from unstructured political events (1200 records) produced for accurate political event prediction; data was pulled from the archives of web news accumulated over the last 5 years to better understand the impact of such impact discovered in this article. This recommended work includes the advantages of Spatiotemporal Analysis of Web News Archives for forecasting network features modeled through political events and converting them into possible information based on natural language processing qualities. The suggested approach constructs a spatial analysis based on hotspots for estimating the sequence of political events in India. Lastly, the resulting data is nurtured into several classifiers for a more reliable prediction and identification procedure. This proposed technique reached a maximum frequency of 78.21 percent and 93.58 percent, respectively, when compared to the Random forest method and the K-neighbor neighbour (KNN) algorithms.
Ultrasound Indicated- and Physical Exam Indicated Cervical Cerclage in Twins versus Singleton Gestations
Authors: Komem Daphna Amitai , Meyer Raanan , Yagel Itai , Shai Daniel , Mashiach Roy , Hendler Israel , Mazaki-Tovi Shali , Yinon Yoav
Published: April 2022

Background: The use of cervical cerclage in singleton gestations is a well-established method to prevent preterm birth. Although cervical cerclage is becoming more frequently used among twin pregnancies, it is still a matter of great controversy. The purpose of this study was to compare the safety and efficacy of physical examination- and ultrasound-indicated cervical cerclage in twin versus singleton gestations.Methods: A retrospective cohort study of all ultrasound (cervical length ≤25 mm) and physical examination indicated cerclage cases performed over a 9-year period. The primary outcome was the time interval from cerclage placement to delivery. Results: The study cohort included 100 singleton and 16 twin pregnancies. Time interval from cerclage placement to delivery was comparable in twin and singleton gestations (14.1 versus 16.3 weeks, p=0.11), as well as the rates of preterm births <28 and <32 weeks. The rate of alive newborns >24 weeks was lower in the twin group (62% versus 89%, p=0.045). Regression analysis identified that cervical dilation, but not twin gestation, was the only factor independently associated with increased risk for birth before 32 weeks.Conclusion: Ultrasound-indicated and physical examination-indicated cerclage in twin and singleton gestations have comparable efficacy.
A Novel Estimation of Tearing Limit in Deep Drawing Process Based on Strain Energy; Experimental Characterization and Numerical Validation
Authors: Aminzadeh Ahmad , Khaboushani Mohammad , Parvizi Ali
Published: April 2022

Deep drawing is a forming process widely used in aerospace, military, automotive, and various industries. One of the essential useful parameters in the quality of deep-drawn products is Blank Holder Force (BHF). By Controlling BHF during the process, formability has been improved, reduced forming energy, and sheet thickness. Tearing is one of the most common and crucial defects in this process due to high radial stress in the cup's wall, resulting in many limitations in this field. In this process, the blank holder force plays an indispensable role in causing tearing. Therefore, controlling blank holder force during the process would be inevitable to avoid tearing or even wrinkling. This study aims to calculate the tearing limit with new criteria in analytical dominating plasticity Equations based on the slab Method. The St14 sheet with 1 mm thickness and 200 mm diameter is used in this study. The maximum blank holder force in each stage of punch stroke with new criteria based on strain energy with three different frictional coefficients is calculated, compared, and verified with FEM simulation and experimental results. Analytical results with new criteria are also compared with previous procedures. Finally, it is realized that results related to energy criteria have a lot more similarity with FEM simulation and experimental results in comparison with the previous ones.
Association between atherogenic index of plasma and carotid artery plaque in patients with coronary heart disease in different glucose metabolism states: a RCSCD-TCM study in China
Authors: Yu Chunquan , He Yuanyuan , Li Zhu , Yu Lu , Liu Yijia , Li Lin , Yang Rongrong , Wang Xianliang , Gao Shan
Published: April 2022

BackgroundThe atherogenic index of plasma (AIP) index can be used as a powerful biomarker of dyslipidemia and atherosclerosis (AS). However, there is limited evidence on the relationship between AIP index and carotid artery plaque (CAP) in patients with coronary heart disease (CHD).MethodsThis is a retrospective study of 9281 CHD patients who underwent carotid ultrasound. Participants were divided according to AIP index tertiles (T1: AIP index < 1.02, T2: 1.02≤ AIP index < 1.25, T3: AIP index ≥ 1.25). The presence or absence of CAP was determined by carotid ultrasonography. Logistic regression was used to analyze the relationship between AIP index and CAP in CHD patients . The relationship between AIP index and CAP was also assessed according to sex, age, and glucose metabolic status.ResultsThe baseline analysis showed that there were significant differences in related parameters among CHD patients who were divided into three groups according to the tertiles of AIP index. Compared with T1 of AIP index, the odds ratio (OR) of the T3 of AIP index in CHD patients was 2.19 (95% confidence interval [CI]: 1.91-2.52). The association between the AIP index and the CAP was higher in female (OR: 2.42; 95%CI: 2.02-2.90) than in male (OR: 1.89; 95%CI: 1.52-2.35). OR value of patients less than 60 years old (OR: 2.11; 95% CI: 1.70-2.63) is lower than that of patients over 60 years old (OR: 2.18; 95%CI: 1.83-2.61). AIP index was significantly associated with CAP risk in different glucose metabolic states, with diabetes having the highest OR values (OR: 4.18; 95%CI: 2.97-5.88).ConclusionAIP index and CAP were significantly associated in CHD patients.In CHD patients, the association between AIP index and CAP was higher in female than in male, and lower in patients aged less than or equal to 60 than in patients aged more than 60. Under different glucose metabolism conditions, the association between AIP index and CAP in CHD patients was the highest in diabetes.
Common solution of split null point, split variational inequality and fixed point problems for a nonexpansive semigroup
Authors: Furkan Mohd , Husain Shamshad , Khan Faizan Ahmad , Khairoowala M. U.
Published: April 2022

The primary goal of this paper is to find a common solution of a split null point problem, split variational inequality problem and fixed point problem for a nonex-pansive semigroup with the help of new type of iterative algorithm. We construct that the sequences induced by the proposed iterative method to solve the above stated problems in the setting of real Hilbert spaces and obtain a strong convergence theorem. We also deduce certain consequences from the main convergence result. At the end, a numerical experiment is shown to demonstrate the convergence analysis of proposed iterative method. The methodology and conclusion described in this work extend und unify previously published findings in this field.
Postoperative and Postdischarge Nausea & Vomiting following Ambulatory Surgery: A Retrospective Cohort Study comparing Incidence and Associated factors
Authors: Xiao Mark , Yao Dongdong , Fields Kara Gayle , Sarin Pankaj , Macias Andres , Sunil Sunil , Juang Jeremy
Published: April 2022

BackgroundAmbulatory surgery is often followed by the development of nausea & vomiting (N/V). Although risk factors for postoperative nausea & vomiting (PONV) are often studied, PONV is not well understood in context of a patient’s home. This is especially troublesome given the potential consequences of postdischarge nausea & vomiting (PDNV), which include major discomfort and hospital readmission.MethodsIn this retrospective cohort study, data from 10,231 adult patients undergoing ambulatory surgery with general anesthesia were collected and analyzed. Multivariable multinomial logistic regression was used to assess the association between patient & operative characteristics (including age, body mass index (BMI), American Society of Anesthesiologists (ASA) classification, current smoker status, and intra & postoperative opioid usage) and the odds of experiencing N/V only in the postanesthesia care unit (PACU), only at home, or in the PACU and at home, as compared to not experiencing N/V at all. ResultsIn this study, 17.8% of all patients developed N/V in at least one location following ambulatory surgery with general anesthesia. Patients who experienced N/V in the PACU had 3.05 (95% confidence interval: 2.55-3.65) times the risk of reporting N/V at home than those who did not. Multivariable multinomial logistic regression found that younger age, greater hydromorphone use, and female sex were associated with increased likelihood of experiencing N/V in all settings. Increased morphine usage was found to be associated with greater odds of experiencing Home only and PACU plus Home N/V, but not PACU only N/V. Greater oxycodone and volatile anesthetic usage were associated with lower and higher odds of experiencing PACU only N/V respectively, but neither were significantly associated with Home only and PACU plus Home N/V.ConclusionsPatients experiencing N/V in the PACU are observed to develop PDNV disproportionately. N/V at home and N/V in the PACU, while having some overlap, are associated with several unique indicators, including usage of oxycodone, morphine, and volatile anesthetics. More investigation into PDNV specific indicators and prevention strategies is warranted. Trial RegistrationN/A
Determining levels of linguistic deficit by applying cluster analysis to the aphasia quotient of Western Aphasia Battery in post-stroke aphasia
Authors: Yan Zhijie , Xu Shuo , Zhang Jingna , Li Chong , Zhang Yongli , Chen Mengye , Li Xiaofang , Jie Jia
Published: April 2022

Background The aphasia quotient of Western Aphasia Battery (WAB-AQ) has been used as an inclusion criterion and as an outcome measure in clinical, research, or community settings. Although the WAB-AQ is commonly used to measure recovery, there was no quantitative relationship between WAB-AQ and severity classification. This study aimed to quantitatively determine levels of linguistic deficit by using a cluster analysis of the WAB-AQ in post-stroke aphasia (PSA). Methods 308 patients were extracted from the database. Cutoff scores defined by mean overlap WAB-AQ scores of clusters by systematic cluster analysis, the method of which is the farthest neighbor element, and the metrics are square Euclidean distance and Pearson correlation, performed on the full sample of WAB-AQ individual subitem scores. A 1-way analysis of variance, with post hoc comparisons conducted, was used to determine whether clusters had significantly difference. Results Three clusters were identified. The scores for severe, moderate and mild linguistic deficit levels ranged from 0 to 30, 30.1 to 50.3, and 50.4 to 93.7, respectively. Conclusions For PSA, the cluster analysis of WAB-AQ supports a 3-impairment level classification scheme.