bluuebunny/crossref_metadata_2025 huggingface dataset:
Kinetic Model And Effective Diffusivity Of Frozen-Dryed European Blueberry (Vaccinium Myrtillus)
Authors: AYRIKSA Mutlucan , ACAR Bahadir , DAĞDEVİREN Abdullah , ROSHANAEI Khandan , COŞKUN Tuba , KAYATAŞ ONGUN Göknur , ÖZKAYMAK Prof. Dr. Mehmet
Published: June 2021

In current study, the freeze-drying (FD) method has been investigated. This method is the healthiest drying method that used in recent years by extending the shelf life of the products and preserving the beneficial flavors in its content. Antioxidant, antimicrobial, antidiabetic, anti-inflammatory, antiseptic, etc., are the most emphasized role among the berries. Thus, blueberry is one of the great aspects to be a case for drying. Blueberry (Vaccinium Myrtillus), which is an opulent source of many phenolic compounds with known properties, has been determined. In the study, blueberries by the weight of 100 g and with a thickness of 5 mm were placed in the drying device, and the data were processed by observing the weight loss every two hours after being subjected to the drying process for 14 hours. 8 different kinetic drying models were applied to the acquired data using the Matlab program. As a result of the application, the estimated standard errors (RMSE), chi-square (X2), regression coefficients (R2) were calculated, error analysis was performed, R2, X2, and RMSE values were found, as 1.4686 ×10-2, 2.875×10-4 and 9.978 ×10-1. According to these results, it was determined that the most suitable model is the Page model. Also, the effective diffusivity coefficients for blueberries were calculated as 2.57665 × 10-12 m2/s.
Spirit of Balinese Local Heroes Transformed into Puppets Show on YouTube as ELT Media for Building Students' Character
Authors: Purandina I Putu Yoga , Wedananta Kadek Adyatna
Published: June 2021

Balinese Local Heroes should be role models for all children around Bali. The spirit of the heroes is full of positive characters. Those characters are essential in building a good personality in every single kid. This study aims to analyze Balinese local heroes' effect into puppets show on Youtube as ELT media for building students' character. The research was designed as a qualitative study. The data taken from the observed interaction at the puppets showed on YouTube that students watched. The obtained data were students' and parent's data interviews and questionnaires. The study results showed that Balinese Local Heroes' spirit transformed into puppet shows on YouTube affected students accurately because the media was engaging. Some character values were affected, willingness to sacrifice, bravery, defense of truth and justice, noble, responsible, and patriotic. The social function of all of the values was essential. The values transformed into a positive attitude in social life. The student became a good helper to the people who need help. They clean the environment without any intention and have a responsibility to do their duty as a student.
The Effect of Feedback on the Application of Based Chemistry Practicum Modules on Local Content-Students' Science Process Skills
Authors: Sari Ratih Permana , Hasibuan Molani Paulina , Sulastri Sulastri
Published: June 2021

This study aims to analyze the effect of feedback from local content-based practicum modules on students' science process skills. Research subjects for product trials developed in this study were students of class XI using a purposive sampling technique with a sample size of 60 students. The method used in this research is quasi-experimental (quasi-experimental). The research instrument was a feedback rubric on applying a local content-based practicum module, observation sheets, and tests on the results of Science Process Skills (KPS). Data processing and analysis is carried out by comparing the initial and final science process skills scores by looking at the science process skills N-Gain score. Hypothesis testing uses the T-test to apply a local content-based practicum module on science process skills by analyzing the initial and final science process skills scores. The highest percentage result lies in the indicator of planning an experiment or investigation and using experimental tools and materials, namely 90%. There is a difference between a class that implements a local content-based practicum module and is given feedback with a class that uses a regular module for each class. The experimental class had an N-gain value of 0.75 or in the high category, while the control class had an N-gain value of 0.64 or in the moderate category. There are differences in students' Science Process Skills (KPS) using local content-based practicum modules with conventional practicum modules.
Electronic control of the dispatch schedule as means of reduction of emissions of harmful substances by buses
Authors:   Don State Technical University, Rostov-on-Don, Russian Federation, Popov S. I. , Galchenko G. A. ,   Don State Technical University, Rostov-on-Don, Russian Federation, Marchenko Yu. V. ,   Don State Technical University, Rostov-on-Don, Russian Federation, Drozdov D. S. ,   Southern Federal University, Rostov-on-Don, Russian Federation
Published: June 2021

Introduction. Environmental contamination by vehicles is one of the main and important questions. Road transport is on the first place by quantity of harmful substances released into the atmosphere. The railway transportation pollutes environment by 3 %, planes — by 6 % from the total amount of pollution. The rest is motor transport. As it is known, the maximum quantity of harmful substances is thrown out in an idle mode of work of the engine, i.e. at idle times at stops. The improvement of an ecological situation on transport highways is possible by the optimization of movement of city public transport. Problem Statement. The task was to develop a project that allows you to eliminate violations of the dispatch schedule of city buses. It is proposed to use the computer program "Line Dispatcher" developed by the authors and a mobile application to monitor the compliance with the dispatch schedule. Theoretical Part. The field observations carried out on one of the most intense sections of the transport arteries of Rostov-on-Don — the ring at the intersection of Vavilova and Koroleva streets — show how many buses produce harmful emissions only on one section, stand idle at the stop, do not fulfill the dispatching schedule, and, thereby, worsen the environmental situation in the city. The authors have developed a computer program "Line Dispatcher", which allows you to: download a map of the city or a district, the information about the stops on the route and the timetable; choose the desired route; monitor the movement of the bus according to the schedule. The mobile app can be installed on any smartphone of the driver and dispatcher. Conclusion. A practical solution is proposed to optimize the activity of public transport, which will eliminate downtime at stops due to electronic control of the dispatch schedule and reduce emissions of harmful substances by urban public transport.
Methods for determining the effective height of the pipe taking into account the dispersion of emissions in the production facilities working area
Authors:   Voronezh State Technical University, Voronezh, Russian Federation, Manokhin V. Ya. , Ivanova I. A. ,   Voronezh State Technical University, Voronezh, Russian Federation, Golovina E. I. ,   Voronezh State Technical University, Voronezh, Russian Federation
Published: June 2021

Introduction. In order to determine the height of the rise of the polluted substances above the source of the pollution, it is important to know the exact distribution of the gas plume. Problem Statement. The determination of the dust concentration in the working area of asphalt concrete plants should take into account the assessment of the concentration of harmful substances in the working area of the asphalt concrete plant. The study is the analysis of methods for determining the effective height of the pipe, taking into account the dispersion of emissions in the working area. Theoretical Part. The paper considers the dependences of the estimation of the initial rise of the gas jet, proposed by Berland, Holland, Briggs, and the specialists of the Tennessee Valley. The value of the initial rise of the impurity jet depends on the moment of the amount of gas movement, the thermal power of the wind speed carrying the jet, and the conditions of thermophoresis. The paper presents the comparative graphs of the calculation of the level of the initial rise of the gas jet at different rates of gas exit from the pipe and constant wind speed. Conclusion. The method of taking into account the initial rise of the heated gas jet gives us better convergence in the calculations of the maximum surface concentrations of harmful substances and in the estimation of distances to them.
The Contribution Value of Conservation Institution to Animal Welfare Aspects at Serulingmas Wildlife Recreation Park, Banjarnegara
Authors: Setiawan Wibiyanto , Sunarminto Tutut , Masy'ud Burhanuddin
Published: June 2021

The main functionof conservation institutions is to control breeding and wild plants and rescue wild plants and animals while maintaining the species purity. This role requires conservation institutions to contribute toanimal conservation to save and conserve wild animals ex-situ. This research aims to determine the contribution value of Serulingmas Wildlife Recreation Park as an implementationof animal welfare. The data was collected through interviews and field observations. The results showed that the implementation achievement of animal welfare at Serulingmas Wildlife Recreation Park was classified as good with an achievement value of 76.61.However, the contribution value of Serulingmas Wildlife Recreation Park to the animal conservation aspects was still categorized as low, which was mainly due to the low animal births. Increasing the success of animal births could be carried out through coaching on technical aspects such as improving animal health management and facilities.Keywords: animal welfare, ex-situ conservation, conservation institution, wildlife conservation
Technology Transfer for Climate Change Mitigation: A Perspective from Kenya
Authors: Mwaura Caroline
Published: June 2021

The impact of climate change continues to be experienced worldwide. Treaties such as the UN Framework Convention on Climate Change (UNFCCC) of 1992 and the UNFCCC Paris Agreement of 2015 demonstrate the value that UN Member States attach to reaching consensus on climate change mitigation steps. In this thematic report, the author looks at the issue of climate change mitigation technology transfer (TT) from a Kenyan perspective, specifically with reference to Kenya’s National Climate Change Action Plan (NCCAP), and to provisions in Kenya’s patent law that are relevant to TT licensing agreements between foreign and Kenyan entities.
CLINICAL RESULTS OF COMPLEX THERAPY ОF PATIENTS WITH ACNE - RESIDENTS OF IODINE DEFICIENCY REGION
Authors: Karvatska Yu.P. , Denysenko O.I.
Published: June 2021

The аim of research – the clinical results of complex therapy in patients with acne vulgaris- residents of the iodine deficiency region should be determined and analyzed consideringthe state of their pituitary-thyroid system, intestinal microbiota and immunologicalparameters.Material and methods. The study involved 109 patients with moderate to severe acnevulgaris, who are the residents of Chernivtsi region - a region with natural iodinedeficiency. Examination of the patients revealed changes in the pituitary-thyroid system,immunological parameters and intestinal biocenosis, which corresponded to the severityof dermatosis. During treatment, patients were divided into 3 groups: I comparative - 36people who received conventional acne therapies and medicines to normalize thyroidhomeostasis; group II comparative - 36 patients who were additionally prescribedprobiotics, and ІІІ (main) - 37 persons who received complex treatment with the additionaladministration of probiotics and immunotropic drug. The effectiveness of treatment ofpatients was evaluated by their earliest and long-term clinical results using statisticalanalysis methods.Results. It has been established that complex therapy of patients with moderate and severeacne vulgaris - residents of the iodine deficiency region with the administration alongsidewith the conventional acne therapy of medicines that normalize detected changes in thepituitary-thyroid system, immunotropic drug glucosaminylmuramyl dipeptide (licopid))and probiotic (lacium) reliably reduces (p <0.01) in comparison with conventional acnetherapy or conventional acne therapy with additional probiotics administration the termsof regress of acute inflammatory elements of acne with the achievement of the state ofclinical remission of dermatosis, (respectively: by 1,54 and 1,41 times). The frequency ofexacerbations acne process of patients with moderate and severe acne vulgaris duringthe year were also reduced (respectively: 1.59 and 1.26 times) relatively to patients in thecomparison groups.Conclusion. The complex therapy of patients with moderate to severe acne - residentsof the iodine deficiency region with administration of medicines to normalize thyroidhomeostasis, immunotropic drug glucosaminylmuramyl dipeptide (licopid) and probiotic(lacium) reliable improves the earliest and long-term clinical results of their treatment incomparison with conventional treatment or treatment using only the probiotic additionalprescription.
TEACHING OF CLINICAL ANATOMY AND OPERATIVE SURGERY TO FOREIGN STUDENTS IN REMOTE CONDITIONS: ADVANTAGES AND DISADVANTAGES
Authors: Gargula T.I.
Published: June 2021

The introduction of distance learning in higher educational medical estalishments underconditions of pandemia has led to a reorganization of the educational process usingnew teaching methods, information and communication technologies (online platforms,video communication programs). In the system of training a qualified physician, clinicalanatomy and operative surgery occupy a leading place, as it develops clinical thinking,stimulates teamwork and is the basis for further study of surgery.The aim of the article - to highlight the advantages and disadvantages of teachingclinical anatomy and operative surgery to foreign students in terms of distance learningand ways to improve them.Conclusions. The study of clinical anatomy and operative surgery by foreign studentsin the context of distance learning has a number of advantages and disadvantagescompared to the traditional form. The use of the online platform Moodle (with studymaterials) and the Microsoft Teams service made it possible to conduct video lecturesand seminars online using interactive teaching methods that promote the motivationincrease and independence of foreign students. "Virtual" operational interventions usingan interactive method is a business game which allows not only to study the stages ofoperations but also to consolidate the algorithm of actions in different circumstances. Theuse of virtual and augmented reality technologies in the educational process becomes theclinical anatomy mastering better, makes it possible to improve its surgical component,which is especially important in the absence of the possibility of training operations.
REFLEXIONES A PROPOSITO DE LA REALIDAD SOCIAL, LA TRADICIÓN JURÍDICA Y LA MORAL CRISTIANA EN EL MATRIMONIO ROMANO ( I )
Authors: Fernández de Buján Antonio
Published: June 2021

El matrimonio como toda institución que tiene una tradición de siglos es un producto histórico. Constituye la expresión en cada época de una moral y de unos usos sociales, en la que se refl ejan, si bien en una mayor medida en unas etapas que en otras, las tensiones, equilibrios, resistencias y oscilaciones, que las nuevas realidades o los cambios de mentalidad en una parte del universo social, producen en la valoración intrínseca de la institución, así como en el juego de fuerzas contrarias que aspiran a su conservación o remodelación. Sólo desde la interpretación de las fuentes de conocimiento que conforman la experiencia histórica que supuso la clásica, y siempre latente, tensión entre una concepción laica y secularizadora del matrimonio y otra concepción propia de una moral sacralizada y canónica, podrá procederse con fundamento a una adecuada valoración de la realidad presente, de su regulación jurídica y, en su caso, a su eventual reforma. El modelo matrimonial que caracteriza, en buena medida, en sus diferentes perspectivas, la denominada tradición de pensamiento occidental europeo y americano, tiene sus principales fuentes en el Derecho romano y en el Derecho canónico . Pero sentada esta afi rmación, que parece tener un carácter indubitable, no se ponen de acuerdo los autores sobre el papel y el grado de infl uencia ejercido por cada una de éstas. Se llegado incluso a afi rmar por algunos autores que la institución del matrimonio romano constituye la más grande de las creaciones de su genio jurídico, frente a otros estudiosos que, ubicados en el polo opuesto, opinan que es el matrimonio la institución en la que más se ha echado en falta el genio jurídico de Roma.
ALOÍSIO SURGIK. VIAJANDO PELA HISTÓRIA. DO DIREITO ROMANO AO DIREITO CONTEMPORÂNEO.
Authors: Montero Ramón Rodríguez
Published: June 2021

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Guided discovery learning, personality traits, and speaking confidence of Iranian Intermediate EFL Students
Authors: Darakhani Leili , Rajabi Peyman , Mahmoodi Keivan
Published: June 2021

The current work aims to examine the association between Guided Discovery Learning (GDL) and personality traits and speaking confidence of Iranian EFL learners in terms of their gender. The study was conducted based on a quantitative-descriptive research method and quasi-experimental design. Accordingly, 60 participants were chosen in terms of convenience-random sampling from two language institutes in Tehran. They included both female (N=30) and male (N=30) of general English courses and were in the age range of 15 to 34 years. The results revealed that extraversion made a significant contribution to the self-confidence of Iranian EFL learners. Also, the guided discovery resulted in a more realistic classroom with an atmosphere like daily life as the learners were more active and responsible. Our findings might have significant implications for the curriculum and material designers to incorporate the GDL principles and students’ personality traits.
Analysis of Hublot’s development strategy in the watch market
Authors: Butov Aleksandr , Velikorossov Vladimir , Maksimov Maksim , Prodanova Natalia , Akulinin Feodor , Zanguttina Gulnar
Published: June 2021

The purpose of the presented article is to study the strategy of the Hublot company at all stages of its life cycle, and the tasks of the study include the study of the history of the company's development and its competitive advantages in the watch market. Aspects of competition in the luxury watch sector are reviewed, as well as measures taken by the company's management to mitigate the effects of the coronavirus pandemic in 2020.
The role of secondary use of building materials in the circular economy
Authors: Magomedov Kemran Abdullaevich , Gundareva Alexandra Andreevna , Komarov Vladislav Alekseevich , Abukov Shamil Zabitovich
Published: June 2021

The article considers the role of secondary use of building materials in the circular economy. The paper considers the method of cascading use of wood, used in the practice of European specialists, which allows to increase the period of use of building materials. The author concludes that nowadays the problems of resource shortage and rapid climate change are encouraging society to move towards more sustainable solutions for the construction sector. Wood, as a widely available and naturally grown material, is of particular importance for achieving the environmental goals set by the EU and national authorities. The use of wood in construction has increased in recent decades. However, the use of a secondary method of wood processing in the circular economy is rarely used in practice, although the economic effect of this process is quite high.
De Viena a Compostela. Libros y lecturas de la condesa de Eril
Authors: Mena Acevedo Daniel
Published: June 2021

El pleito que se inició en 1765 como consecuencia de la muerte del conde de Amarante nos ofrece una concentración excepcional de fuentes para el estudio de los libros y lecturas de su viuda, la condesa de Eril: inventarios, correspondencia epistolar, memoriales e interrogatorios. Nuestro objetivo es conocer el tamaño y los espacios de la biblioteca, su formación y, sobre todo, los contenidos de los libros.
Motivações de estudantes de pedagogia para a escolha do curso
Authors: Alves Iron Pedreira , Ribeiro Marinalva Lopes , Gomez Daboin Maria Mercedes
Published: June 2021

A escolha de uma carreira é um passo importante na formação profissional, pois os motivos que sustentam essa decisão afetam o investimento pessoal na aprendizagem e o compromisso com a sua realização. O presente trabalho, oriundo de uma pesquisa de abordagem qualitativa, teve como objetivo conhecer as motivações de estudantes de Licenciatura em Pedagogia para a escolha do curso. Para a produção dos dados, foram realizadas entrevistas semiestruturadas com a participação voluntária de seis estudantes do primeiro semestre de uma universidade pública da Bahia, as quais receberam nomes fictícios a fim de terem suas identidades preservadas. As respostas das participantes foram transcritas e analisadas mediante aproximações com a técnica análise de conteúdo. Os resultados corroboraram os achados de outros estudos, demonstrando a importância dos motivos altruístas e intrínsecos para a escolha da docência. Os motivos extrínsecos, entretanto, não parecem ter afetado a decisão das estudantes.
Respons Pedagang Kaki Lima Terhadap Surat Edaran Bupati Ponorogo Nomor 713/235/405.01.3/2021 Tentang Pemberlakuan Pembatasan Kegiatan Masyarakat Untuk Pengendalian Penyebaran Covid-19 di Kabupaten Ponorogo
Authors: Imamudin Iqbal Akbar , Sari Sismonika Pupita , Pamungkas Sujud Tri Fajar , Mahardhani Ardhana Januar
Published: June 2021

Implementasi dari Surat Edaran Bupati Ponorogo nomor 713/235/405.01.3/2021 tentang Pemberlakuan Pembatasan Kegiatan Masyarakat Untuk Pengendalian Penyebaran Covid-19 di Kabupaten Ponorogo menimbulkan pro dan kontra di masyarakat terutama untuk pelaku usaha yaitu pedagang kaki lima yang berdampak secara langsung. Penelitian ini dilakukan di Jalan Suromenggolo Kabupaten Ponorogo. Metode penelitian menggunakan kualitatif dengan metode pengumpulan data adalah observasi, wawancara, dan dokumentasi. Hasil dari penelitian diketahui bahwa 44,8% pelaku usaha setuju dengan pemberlakuan jam malam dan 55,2 % pelaku usaha tidak setuju dengan pemberlakukan jam malam. Selanjutnya 92,1% para pelaku usaha setuju dengan kebijakan yang PPKM dan 7.9% pelaku usaha yang tidak setuju dengan kebijakan PPKM.  Ada dua alternatif untuk mengatasi keluarnya surat edaran tersebut, yaitu: pertama pemerintah melakukan peninjauan ulang dan merevisi surat edaran dan kedua adalah pemerintah hendaknya menyiapkan aplikasi order online agar kegiatan jual beli pdagang kaki lima tetap bisa dijalankan.
Cardiotoxicity of antiangiogenic drugs: causes and mechanisms
Authors: Tomaszewska Beata , Muzolf Małgorzata , Grabysa Radosław , Bodnar Lubomir
Published: June 2021

Therapy with angiogenesis inhibitors is undoubtedly an advancement in cancer treatment; however, it is associated with a risk of developing cardiotoxicity, which most often manifests in myocardial contractile dysfunction or an increased risk of thromboembolic events. Heart failure is observed in 2–4% of patients treated with bevacizumab and in 3–8% of patients on antiangiogenic tyrosine kinase inhibitors.

The proposed pathomechanisms underlying the impairment in systolic function during antiangiogenic drug treatment include mitochondrial dysfunction, a secondary reduction in cardiomyocyte ATP production and redox imbalance, which may contribute to pathological states known as “free radical diseases”. Additionally, therapy with angiogenesis inhibitors may also cause cardiac oxidative stress.

The risk factors for cardiac complications include arterial hypertension, which is a known “class effect” of this class of drugs, as well as a number of other factors such as age, comorbidities, prior radiotherapy and baseline left ventricular ejection fraction.

The cardiovascular diseases are still the first cause of death in the world. The more effective oncological treatment becomes, the more often comorbidities occur. This fact seems to demand interdisciplinary approach from investigators and practitioners.

This article presents the current state of knowledge on the molecular mechanisms of cardiotoxicity of antiangiogenic drugs used in routine clinical practice.
Small animal general practice veterinarians' use and perceptions of synchronous video-based telemedicine in North America during the COVID-19 pandemic
Authors: Bishop Greg T. , Rishniw Mark , Kogan Lori R.
Published: June 2021

OBJECTIVE

To assess small animal general practice veterinarians' use and perceptions of synchronous video-based telemedicine before and during the coronavirus disease 2019 (COVID-19) pandemic.

SAMPLE

550 respondent veterinarian members of the Veterinary Information Network (VIN).

PROCEDURES

An anonymous online survey was used to gather data from VIN-member veterinarians in small animal general practice regarding their perceptions and use of synchronous video-based telemedicine. Two emails to all VIN members were used to distribute the web-based questionnaire. For consistency, only responses from North American veterinarians who reported working in small animal general practice were included in analyses. Responses were collected between September 28, 2020, and October 21, 2020.

RESULTS

There were 69,488 recipients and 680 respondents (1.0% response rate), 550 of whom had North American internet protocol addresses and reported working in small animal general practice. Not all respondents answered all questions. Use of video-based telemedicine substantially increased among respondents during the COVID-19 pandemic, and most (86/130 [66.2%]) reported little to no difficulty in adopting videoconferencing. Respondents also reported that telemedicine took less time (61/135 [45.2%]) and resulted in less financial compensation (103/135 [76.3%]) than in-person consultation. Several respondents reported concerns regarding legal issues and potential inferiorities of telemedicine.

CONCLUSIONS AND CLINICAL RELEVANCE

Our results indicated that a substantial proportion of respondents incorporated synchronous video-based telemedicine into their practices during the COVID-19 pandemic. Despite low perceived difficulty in adopting videoconferencing telemedicine, many planned to discontinue it for some clinical applications once the pandemic is over. Further research is required to elucidate the perceptions and challenges in successful use of veterinary telemedicine.
Concept of Biohydrogen Production by Agricultural Enterprises
Authors: Kukharets Savelii , Hutsol Taras , Glowacki Szymon , Sukmaniuk Olena , Rozkosz Anna , Tkach Oleg
Published: June 2021

Biohydrogen production in agricultural enterprises is an urgent matter. It is appropriate to utilize two methods of biohydrogen production: a thermochemical method – from crop-based biomass and anaerobic digestion (fermentation) method – from animal-based biomass.. It is appropriate to use gasifiers for the thermochemical method and biore-actors for fermentation method.

The theoretical potential of biohydrogen was established with due regard to the amount of biomass which is necessary for utilization in livestock agriculture, for fields fertilization as well as with the consideration of the coefficients of concordance with hydrogen equivalent and loss factor under biohydrogen production. The theoretical potential of biohydrogen from crop-based biomass in Ukraine amounts to 77 billion m3, during the period of three years (on average 25.6 billion m3 per year).
The Analysis of Opinions About Teaching Profession on Twitter Through Text Mining
Authors: Gündüzalp Seda , Şener Gönül
Published: June 2021

Billions of data in social media have provided a very influential platform for researchers to make research on data analysis. In the digital age, it has become essential for conducting an analysis of written things in social media in which the individuals express easily themselves without any pressure and for studying big data. It has been known that there are shared subjects on the education like almost every subject on the Twitter platform. Accordingly, it is often shared about many issues relating to education. The purpose of the present study is to analyze shared ideas on the ‘teaching’ profession through this program, which has become popular recently. It was observed that the shared tweets were often related to the current problems about education and Twitter was used as a platform by the individuals to explain their problems. It was a considerable finding that most of the tweets focused on contracted teaching, the positions of appointment, public personnel selection exam and the system of exams, issues about assignation, paid to teach and interview issues that there are a great number of reaction tweets against negative evaluation about vacations of teacher and particularly, against the situations just like damaging the sanctity the teaching profession and these tweets take place in the category the most retweeted. With this research, it is suggested to make analyses on social media platforms with other data mining techniques on the same subject or different subjects, to analyze the shares of institutions and to examine the sharing of the Ministry of National Education
Social Networking Site Use: Implications for Health and Wellness
Authors: Wright Robert R. , Evans Austin , Schaeffer Chad , Mullins Rhett , Cast Laure
Published: June 2021

Technological advances such as smartphones and tablets have made social media and social networking sites (SNS; e.g., Facebook, Snapchat) increasingly accessible and popular. The literature, however, contains mixed results as to the effects associated with the increased use of SNS, with some studies suggesting benefits and others pointing to detriments to users’ overall wellness (e.g., social, mental, physical). As such, the current investigation examined the wellness of different SNS users among internet users solicited through Amazon’s MTurk (N = 2,083). Participants completed an online questionnaire that assessed their daily use of several SNS and constructs related to social, mental, and physical health. Results suggest that users of image-based SNS (e.g., Snapchat) show the most significant (p < .05) and substantial (d > .20) deficits and users of video-based (e.g., Marco Polo, WhatsApp) and professional (e.g., LinkedIn) SNS manifested the best wellness profiles. However, regardless of SNS type, increased total daily use of SNS was significantly (p < .05) related to worse health and wellness. Thus, differential health and wellness associated with SNS use may be at least partially explained by the type of SNS used such that using certain platforms may be more detrimental or beneficial than others.
Influence of B16/F10 melanoma growth variant on the level of cytochrome C in mitochondria in various organs of female mice
Authors: Frantsiyants E. M. , Neskubina I. V. , Cheryarina N. D. , Surikova E. I. , Nemashkalova L. A.
Published: June 2021

Introduction. Cytochrome C in mitochondria transfers electrons from complex III to complex IV, and it is a signaling molecule in the apoptosis realization.

The objective was to evaluate the level of cytochrome C in cell mitochondria in various organs of female mice with standard and stimulated growth of experimental B16/F10 melanoma.

Methods and materials. The experiment was performed on female C57BL/6 mice (n=168). The groups were: intact animals (n=21); controls with a model of chronic neurogenic pain (CNP) (n = 21); group M — standard B16/F10 melanoma transplantation (n=63), group CNP + M — B16/F10 melanoma transplantation 3 weeks after CNP model creation (n=63). The level of cytochrome C (ng / mg protein) were measured by ELISA (Bioscience, Austria). Statistical analysis of results was performed using the «Statistica 10.0» program.

Results. After 1 week of standard melanoma growth, an increase in the level of cytochrome C by 2.7 and 1.7 times was detected in mitochondria of the brain and liver; by the 3rd week, it decreased in the liver and skin by 1.7 times. In melanoma mitochondria, the level of cytochrome C was lower than in the skin of intact animals: by 2.5 times after week 1, by 4.5 times after week 2, and by 4.6 times after week 3. After 1 week of stimulated melanoma growth, the level of cytochrome C decreased compared control values: by 2.2 times in the brain, by 1.9 times in the liver, by 1.4 times in the skin; by week 3, it decreased by 4.8 times in mitochondria of the brain, by 4.7 times — in the liver, by 2.3 times — in the heart, by 1.9 times — in the skin. In melanoma mitochondria, the level of cytochrome C was lower than in the skin of intact animals: by 15.3 times after week 1, by 10.3 times after week 2, and by 8.8 times after week 3.

Conclusion. Low level of cytochrome C were found in melanoma mitochondria in standard and stimulated tumor growth. The data can be used in the experiment and in clinic for using exogenous cytochrome C as an agent slowing down the malignant process.
Application of categories of the International classification of functioning in the organization of medical rehabilitation of patients who have suffered a new coronavirus infection COVID-19
Authors: Afanasyeva V. V. , Potapchuk A. A. , Chernysh N. V.
Published: June 2021

The objective was to determine the most significant categories of ICF that allow us to provide objective information about the biopsychosocial state of patients who have suffered a new coronavirus infection COVID-19 and to choose the most effective methods of rehabilitation based on the rehabilitation diagnosis of each group of patients.

Methods and materials. On the basis of the clinic of the Pavlov University, a course of medical rehabilitation was conducted for 2 weeks for patients who had suffered a new coronavirus infection in severe and moderate degree of course. 2 groups were formed: EG1-25 people participating in the rehabilitation program with the use of physical exercises and EG2 — 39 people with the use of physical exercises and physiotherapy. A categorical rehabilitation profile of patients by ICF domains was compiled.

Results. As a result of the application of the medical rehabilitation program, a statistically significant improvement in the indicators in EG 2 was revealed. The respiratory function (the Barbell test) improved by 14.6%, the functional state of the cardiovascular system according to the DBP indicator by 3.9%. The analysis of the results of the ICF category «activity and participation» revealed a statistically significant improvement in the motor test parameters (6MSHT) in both groups: by 11.9 % in EG2 and by 20.6 % in EG1.

Conclusions. The results of the study indicate the positive impact of the proposed program of medical rehabilitation and confirm the relevance of the problem, unsolved problems and prospects for scientific research on this topic.
Invasive fungal infection of the central nervous system caused by rare yeast pathogen Malassezia spp. in patients with acute leukemia: case reports and literature review
Authors: Rogacheva Yu. A. , Popova M. O. , Markova I. V. , Paina O. V. , Shmidt D. I. , Pinegina O. N. , Nikolaev I. Yu. , Zubarovskaya L. S. , Klimko N. N.
Published: June 2021

Malassezia spp.is a commensal yeast that represents normal microflora in humans and some animals. However,Malassezia spp.can cause life-threatening invasive mycosis. Evidence on Malassezia spp. infections is limited mostly to a case reports describing disease in newborns and premature infants, because lipid infusions (total parenteral nutrition) given through central venous catheter is a major risk factor. Here, we report two cases of CNS infection caused by Malassezia species in non-neonates with acute leukemia.
Design Of 4DOF 3D Robotic Arm to Separate the Objects Using a Camera
Authors: Fahruzi Akhmad , Agomo Bimo Satyo , Prabowo Yulianto Agung
Published: June 2021

Nowadays robotic arm is widely used in various industries, especially those engaged in manufacturing. Robotic arms are usually used to perform jobs such as picking up and moving goods from their place of origin to the location desired by the operator. In this study, a 3d 4 DOF (Degree of Freedom) robotic arm. The prototype was made to move goods with random coordinates to places or boxes whose coordinates were determined in advance. The robot can know the coordinates of the object to be taken or moved. The arm robot prototype design is completed with a camera connected to a computer, where the camera is installed statically (fixed position) above the robot's work area. The camera functions like image processing to detect the object's position by taking the coordinates of the object. Then the object coordinates will be input into inverse kinematics that will produce an angle in every point of the servo arm so that the position of the end effector on the robot arm can be founded and reach the intended object. From the results of testing and analysis, it was found that the error in the webcam test to detect object coordinates was 2.58%, the error in the servo motion test was 12.68%, and the error in the inverse kinematics test was 7.85% on the x-axis, the error was 6.31% on the y-axis and an error of 12.77% on the z-axis. The reliability of the whole system is 66.66%.
Bezier Curve Collision-Free Route Planning Using Meta-Heuristic Optimization
Authors: Machmudah Affiani , Parman Setyamartana
Published: June 2021

A collision-free route is very important for achieving sustainability in a manufacturing process and vehicle robot trajectories that commonly operate in a hazardous environment surrounded by obstacles. This paper presents a collision avoidance algorithm using a Bezier curve as a route path. The route planning is modeled as an optimization problem with the objective optimization is to minimize the route length considering an avoiding collision constraint. The collision-avoidance algorithm based on curve point analysis is developed incorporating metaheuristic optimizations, namely a Genetic Algorithm (GA) and a Grey Wolf Optimizer (GWO). In the collision avoidance algorithm, checking of curve point's position is important to evaluate the individual fitness value. The curve points are analyzed in such a way so that only the paths which are outside the obstacle area are selected. In this case, besides the minimum length as a fitness function, the constraint is the position of curve points from an obstacle. With the help of meta-heuristic optimization, the developed collision avoidance algorithm has been applied successfully to different types of obstacle geometries. The optimization problem is converted to the maximization problem so that the highest fitness value is used to measure the performance of the GA and GWO. In general, results show that the GWO outperforms the GA, where it exhibits the highest fitness value. However, the GA has shown better performance for the narrow passage problem than that of the GWO. Thus, for future research, implementing the hybrid technique combining the GA and the GWO to solve the advanced path planning is essential.
Perspektif digital marketing communication dalam memasarkan skincare di indonesia
Authors: Hapsara Osrita , Casmudi Casmudi , Sjuchro Dian Wardiana , Murtono Taufik , Asfar Dedy Ari
Published: June 2021

The rapid development of skin care products (Skincare) through social media has changed the paradigm of the digital marketing model in general. This article discusses digital marketing models that skin care products use in marketing their products. The method used was Krippendorff content analysis which was carried out through digital observation on the Instagram account of skin care products (Skincare) Elvicto @ elvicto.id from March 1, 2021 to March 31, 2021. The results of this study indicate that Elvicto is more engaged in a digital marketing communication strategy through marketing. Instagram @ elvicto.id which is dominated by personal selling strategies.
CURRÍCULOS PRATICADOSPENSADOS E EMANCIPAÇÃO SOCIAL NA EDUCAÇÃO DE JOVENS E ADULTOS (EJA)
Authors: Silva Francisco Canindé da , Palhares Emanuella de Azevedo
Published: June 2021

Este trabalho tem como sistema-de-interesse de estudo, contextos de práticas pedagógicas curriculares cotidianas na Educação de Jovens e Adultos (EJA), desenvolvidas por praticantespensantes desta modalidade educativa, e tem como cerne de discussão concepções de currículos praticadospensados na EJA na perspectiva de emancipação social. Nosso campo de pesquisa se relaciona aos contextos em que é desenvolvida esta modalidade – Escola Estadual José Rufino, no município de Angicos/RN. Compreender esta modalidade educativa, amparado pela perspectiva de paradigmas emergentes que propõem outras maneiras de racionalidade, contrapondo-se a arranjos tradicionais e hegemônicos de sociedade e educação constitui objetivo articulador do trabalho. Como forma de subverter a ordem socialmente imposta de saber e de conhecer que se materializa nos currículos praticados, esta pesquisa indagou de que maneira a EJA da Escola Estadual José Rufino vem produzindo conhecimento na perspectiva da emancipação social. Para este fim, recorremos a abordagem qualitativa de pesquisa incorporando a concepção de mergulho com todos os sentidos e narrar a vida e literaturizar a ciência, a fim de apreender a realidade complexa do cotidiano escolar. Cada mergulho durante o percurso desta pesquisa nos possibilitou por meio do olhar atento e sensível, perceber até que ponto práticas curriculares cotidianas produziam sentidos reguladores e emancipatórios. Os relatos das professoras e dos alunos, as interações, relações e ações pedagógicas assumidas em sala de aula se traduziram em solos férteis para captura das práticas curriculares, possibilitando compreendê-las enquanto emancipação e/ou regulação, enquanto situações-limites e/ou inéditos-viáveis.
Vitamin responsive conditions in pediatric neurology
Authors: Bhagwat Chandana , Sankhyan Naveen
Published: June 2021

Vitamin responsive conditions can be either due to inherited defects in the metabolic pathways resulting in vitamin dependency or due to acquired deficiency states. Due to widespread malnutrition and predominantly vegetarian population in India, vitamin deficiency state is quite common and early identification is essential. Inherited defects, if treated earlier, lead to reduced morbidity and mortality and improvement in long-term neurocognitive outcomes. Various vitamin responsive conditions in pediatric neurology shall be discussed in this review. Infantile presentation of thiamine deficiency results in beriberi, and in adults, it leads to Wernicke’s encephalopathy and Korsakoff psychosis. Biotin thiamine-responsive basal ganglia disease is a defect of thiamine transporter 2, which leads to neuroregression and characteristic neuroimaging features of basal ganglia involvement, it responds to high doses of biotin and thiamine. Riboflavin is an enzyme involved in mitochondrial energy synthesis and is supplemented in various mitochondrial metabolic conditions. Brown-Vialetto-Van Laere syndrome is progressive pontobulbar palsy caused by defect in riboflavin transporters responsive to high doses of riboflavin. Pyridoxine responsive epilepsy presents with pharmacoresistant seizures in neonatal or early infantile age, biotinidase deficiency also presents with similar neurological manifestations, but typical cutaneous symptoms of rash and seborrheic dermatitis also occur. Both are epileptic encephalopathies and any infant presenting with epilepsy not responding to conventional AEDs must be given a trial of pyridoxine, biotin, and folinic acid. Vitamin B12 responsive conditions can include deficiency states, such as those manifesting with peripheral neuropathy and the syndrome of infantile tremor syndrome (developmental delay or regression, tremors, and megaloblastic anemia) as well as inherited disorders of homocysteine and cobalamin metabolism. These disorders are differentiated on the basis of clinical phenotype and laboratory parameters (serum B12, homocysteine levels, methylmalonic acid levels, etc.). Infantile tremor syndrome responds drastically to mega doses of Vitamin B12 and other multivitamins. Vitamin E deficiency causes ataxia with Vitamin E deficiency, other vitamins which can neurological symptoms include Vitamin C (pseudoparalysis) and Vitamin K (central nervous system bleeds). It is imperative for a practicing pediatrician to be well versed with these conditions, as these are potentially treatable conditions.
Epileptic Spasms-West syndrome secondary to Dravet syndrome due to SCN gene mutation from India
Authors: Gowda Vykuntaraju K. , Vegda Hemadri , Amoghimath Raghavendraswami , Battina Manojna , Shivappa Sanjay K. , Benakappa Naveen
Published: June 2021

Objectives:

West syndrome (WS) is a triad of epileptic spasms, developmental delay/regression, and hypsarrhythmia. SCN related epileptic encephalopathy is a rare epilepsy syndrome characterized by an early-onset, severe, and epileptic encephalopathy. The causes of WS are multiple and diverse ranging from genetic to structural, metabolic, and unknown causes. The objectives of the study were to report SCN related epileptic encephalopathies with epileptic spasms.

Materials and Methods:

This is retrospective chart review of children presenting with epileptic spasms secondary to SCN gene variants from January 2015 to March 2020 in a tertiary care referral center.

Results:

Out of 15 children, ten were boys. The mean age of presentation was 5 months. Thirteen children had preceded seizures before epileptic spasms in the 1st year of life, two children presented initially with epileptic spasms. No neuro-deficits were noted in all the children. In all the cases electroencephalogram was suggestive of hypsarrhythmia. Routine testing, neuroimaging, and metabolic tests were normal in all the cases. Various pathogenic variants seen in next-generation sequencing were SCN1A in 11, SCN1B and SCN2A in two children each. Three children responded for vigabatrin and five children responded for steroids but all of them had relapse and were refractory to other antiepileptic drugs.

Conclusion:

SCN related epileptic encephalopathy should be considered in the differential diagnosis of epileptic spasms. These infants present earlier compare to classical Dravet syndrome children.
An unusual presentation of biotinidase deficiency in infant: High anion gap metabolic acidosis
Authors: Wali Pooja Shashidhar , Tauro Preetham , Hegde Pavan , Khan Habeeb Ullah , Jaidev M. D
Published: June 2021

Biotinidase deficiency (BTD) is hereditary autosomal recessive disorder with higher morbidity and mortality if left untreated. We report this case to increase awareness about BTD, presenting with infantile seizures, encephalopathy with high anion gap metabolic acidosis, eczema and to emphasize the importance of early diagnosis in reversal of metabolic acidosis and seizures refractory to multiple anticonvulsants with biotin replacement.