bluuebunny/crossref_metadata_2025 huggingface dataset:
Invited to dinner, but not to the table: web content accessibility evaluation for persons with disabilities
Authors: Yuh Mirabel Nain , Okwen-Akah Gloria Ndum , Nsaikila Melaine Nyuyfoni , Cockburn Lynn , Atengble Kirchuffs , Stewart Ruth , Okwen Patrick Mbah
Published: December 2023

Disability is very common and yet not well understood within sub-Saharan African countries. There has been growing attention to the use of research evidence to improve social inclusion of persons living with disabilities. This article reports on a process that can be used to monitor and evaluate evidence databases to encourage improvements in website and content accessibility for people with disabilities. We examined five evidence communities’ online databases by: (1) assessing the accessibility of these website databases; and (2) assessing the resources within these websites. Finally, we aimed to provide feedback from the evaluation to these evidence databases. We carried out a cross-sectional study of the online evidence databases using the Web Content Accessibility Guidelines – a universal standard for web content accessibility assessment. We assessed access to the databases using a purposive sample of 25 resources within them. Resources are meant to improve practice, policy and decision making for all, including people with disabilities. They include systematic reviews, reports and articles. Accessibility is being able to obtain, understand and use resources; addressing barriers that could hinder this is important. Even though these evidence databases are considered as enabling inclusion and diversity within the evidence ecosystem, their contents are not fully accessible to people with disabilities, and they only partially met the recommendations of the Web Content Accessibility Guidelines.
Anacronismo conceptual: el pecado del historiador intelectual
Authors: Palti Elías J.
Published: December 2023

Los anacronismos conceptuales fueron siempre considerados como uno de los peores pecados en el que podría incurrir un historiador intelectual. El afán de descubrir cómo se fue modificando el sentido de los conceptos fundamentales del discurso político y social y comprender así qué los especifica históricamente requeriría contextualizar los mismos. Particularmente relevante al respecto es la propuesta “contextualista discursiva” de Quentin Skinner y la llamada Escuela de Cambridge. Sin embargo, recientemente ha sido objeto de severas críticas. No sólo se ha puesto en debate la posibilidad de reconstruir históricamente los diversos contextos discursivos y lograr desprenderse del “presentismo” de nuestras propias perspectivas y presupuestos. Lo que se pone en duda es si tal vocación historicista resulta realmente pertinente para la correcta comprensión de los textos del pasado. La misma llevaría a desconocer esa dimensión trascendente de los discursos que les permite trasponerse a sus contextos originarios de producción y proyectarse en el tiempo. Frente a estas críticas en el presente ensayo se reafirma la necesidad de contextualizar históricamente los discursos, así como las consecuencias perversas, en términos metodológicos, implícitas en las posturas que lo niegan.
Operational properties involving functions with generalized continuity
Authors: Campos Matheus Silveira , Vieira Marcelo Gonçalves Oliveira , Braz José Henrique Souza
Published: December 2023

In the work [11], Vieira introduced a new perspective about continuity of functions, which involves the idea of a suitable type of continuity of a function with respect to another function. The inspiration for this notion of generalized continuity arises naturally from the concept of generalized limit of a function with respect to another function, thus expanding the field of mathematical knowledge about continuity of functions. Initially presented by Vieira and Braz in [1], the concept of generalized limit is relevant, since a Riemann integral is a case of a generalized limit, as can be seen in [11]. This article proposes to further explore this notion of generalized continuity and its main focus is to investigate and present operational properties that arise when we deal with functions that exhibit this generalized continuity, operational properties such as composition, concatenation, among others. Through this study, it is hoped to shed light on the meaning and implications of these properties in this context of generalized continuity, allowing a broader understanding of this notion of continuity.
Educação popular como estratégia para melhoria das informações no sistema e-SUS
Authors: Bezerra Isaac Newton Machado , Santos Thayná Menezes , Araújo Andreza Amanda de , Sousa Fabiana de Oliveira Silva
Published: December 2023

Este estudo retrata a experiencia de residentes com a realização de oficinas junto a profissionais do Sistema Único de Saúde utilizando os princípios da Educação Popular em Saúde como metodologia norteadora. Estudo descritivo do tipo relato de experiencia. Foram realizados seis encontros com os profissionais a fim de auxiliá-los na ampliação do seu processo de trabalho e compreensão do9 seu fazer diário, já este apresentava-se desestimulante e robótico. Os encontros evidenciaram a potencialidade presente da Educação Popular em Saúde, pois, a cada momento vivenciado fica nítido o aumento da participação dos profissionais e seu empenho em contribuir de forma positiva com a construção e partilha dos saberes. Esses momentos também serviram para ampliar a compreensão dos residentes sobre a complexidade existente no dia a dia dos Agentes Comunitários de Saúde e sua relação com o território. A vivência partilhada foi imprescindível para fortalecer os vínculos entre residentes e agentes comunitários, potencializando os espaços e enriquecendo a troca de saberes.
Desafios para educadores populares em tempos de educação remota
Authors: Vieira Maria Clarisse , Acuña-Collado Violeta
Published: December 2023

Em 2020 o mundo foi surpreendido com a emergência da pandemia Covid-19. Diante dos desafios decorrentes da crise sanitária, a Faculdade de Educação da Universidade de Brasília buscou alternativas para dar prosseguimento às ações educativas do projeto de extensão na área da educação de jovens e adultos (EJA). Este artigo tem como objetivo compreender, a partir dos conceitos de situações-limites e inédito viável de Freire (1987), os significados da formação e da prática das educadoras populares, em 2021, diante dos desafios do ensino remoto. A metodologia, de base qualitativa, fez uso do método da pesquisa-ação e da sistematização de experiências, por meio de entrevistas e questionários realizados com as educadoras envolvidas no projeto. O texto dialoga com as contribuições de Freire e com autores da área da EJA e da formação de professores. O artigo aponta os desafios vividos no contexto da pandemia, em face da deterioração das condições de vida e saúde, bem como do acesso precário às novas tecnologias, enfrentados por educandos e educadores do projeto. Além disso, mostra que o apoio recebido pelas educadoras populares para o desenvolvimento das atividades pedagógicas foi fundamental para continuarem persistindo nas atividades deles, mesmo em tempos tão incertos.
Biografía de la bioestadística o estadística aplicada. Caso en la FBCB
Authors: Walz María Florencia , Diego Carlos Manni , Ávila Olga Beatriz , Berta Eugenia
Published: December 2023

En este artículo se hace un racconto histórico del surgimiento de la Bioestadística como ciencia per se y, también, de su inserción y evolución didáctico-pedagógica como asignatura en los planes de estudio de las primeras carreras de grado de la Facultad de Bioquímica y Ciencias Biológicas.
Educación de adultos y psicología evolutiva en la transferencia de la DINEA a la Provincia de Entre Ríos entre 1980-1982
Authors: Facciano Jonatan Ruben
Published: December 2023

En este trabajo, inscripto dentro de la historia de la educación y la historia reciente de la Provincia de Entre Ríos, me propongo indagar en los cambios y continuidades en que se inscribe la transferencia a la provincia de Entre Ríos entre los años 1980-82 de los servicios educativos de la  Dirección Nacional de Educación del Adulto (DINEA) enmarcado en un contexto de tensiones internas dentro de la Fuerzas Armadas (FFAA), con la mayor participación de los actores civiles del Proceso de Reorganización Nacional (PRN) y de consolidación del modelo económico y social Neoliberal. En este contexto, las FFAA construyen su rol como actor político en el ensayo de políticas educativas afines a criterios educativos vinculados a su propia estructura de formación y como alternativa a los lineamientos curriculares preexistentes, que daban sentido a la Educación de Adultos, para poder enmarcarla dentro del proceso disciplinador de las Doctrinas de Seguridad Nacional.
Caracterización microbiológica, sensorial y bromatológica de la fermentación de cacao en los genotipos CCN 51 E ICS 95
Authors: Rodriguez Silva Lucero Gertrudis , Sánchez López Diana Beatriz , Espinosa Carvajal Manuel Ramón , Coronado Silva Roberto Antonio
Published: December 2023

La fermentación del cacao es un proceso clave y relevante en la síntesis de moléculas precursoras de aroma y sabor. El objetivo de este estudio fue la caracterización microbiológica, sensorial y bromatológica de la fermentación de los granos de cacao en los genotipos CCN 51 e ICS 95. Se realizó la extracción del grano llevándose a fermentadores semi-escalera durante siete días, tomándose muestras cada 24h para identificación. En laboratorio, se efectuó el aislamiento de los microorganismos e identificación, para levaduras, con la amplificación de la región ITS (Internal Transcribed Spacer) y las bacterias mediante la secuenciación del gen 16S ARN ribosomal. Para el análisis sensorial y bromatológico, se llevó, ha secado el grano hasta obtener 7% de humedad, identificando el perfil sensorial a partir de licor de cacao, a través de evaluadores entrenados. Se identificaron microorganismos como: Candida orthopsilosis, Hanseniaspora opuntiae, Issatchenkia orientalis, Saccharomyces cerevisiae, Kodamaea ohmeri, Tatumella sp., Tatunella ptyseos, Lysinibacillus, Lactiplantibacillus plantarum, Acetobacter pasteurianus, Acetobacter sp., Gluconobacter sp., Gluconacetobacter sp., Bacillus sp., Bacillus cereus y Serratia marcescens. Como resultado sensorial se determinó que el ICS 95 presentó mayores descriptores sensoriales positivos como nuez, frutal y floral en comparación al CCN 51, que refleja sabores básicos más intensos. Por el contrario, CCN 51 se resaltó en mayor proporción los polifenoles, la teobromina y carbohidratos. Estos resultados serán el punto de partida sobre la potencialidad que brindan los microorganismos en la calidad sensorial, para así mejorar de manera significativa los procesos de fermentación a nivel industrial.
Subjetividad e historia en el debate Foucault-Derrida
Authors: Routier Pablo Martín
Published: December 2023

El presente artículo se propone analizar el debate que enfrentó a Jacques Derrida y Michel Foucault en torno a la Historia de la locura escrita por este último. En primer lugar, se ofrecerá una reconstrucción de las posiciones y argumentos sostenidos por cada autor, poniendo de relieve la problemática en torno a los modos de pensar y escribir la historia por parte de cada uno. En segundo lugar, se intentará aportar una respuesta diferente a la dada por Foucault en 1972 al problema planteado por Derrida sobre la posibilidad de una historia crítica de la razón. En efecto, Foucault se centró en la discusión del texto cartesiano y en la importancia de las modificaciones al nivel del sujeto que, en dicho texto, implicaron la exclusión de la locura. En este artículo, sin embargo, aunque de manera complementaria, se retomará el acontecimiento del “Gran Encierro” atendiendo allí a las marcas de la conformación de una subjetividad moral. Se espera, a través de este análisis, poner de relieve la relación entre subjetividad e historia como eje de la historización crítica desarrollada por Foucault y atender a la objeción derridiana desde un enfoque distinto al planteado por el propio Foucault.
La atención a la diversidad desde la tutoría
Authors: Torres Marrero Elena
Published: December 2023

La atención a la diversidad en el aula es un trabajo en equipo orientado a conocer al alumno en profundidad, descubrir sus intereses, sus estilos de aprendizaje y de todas aquellas características que dificultan y potencian su aprendizaje. Un claustro que se forma en dificultades de aprendizaje, necesidades educativas especiales y metodologías activas y que busca distintos modos de atender a la diversidad unido a la implicación de las familias, son las piezas claves para conseguir que cada alumno pueda llegar, desde su propia situación, a conseguir los objetivos propuestos.
Pedagogía terapéutica, la individualización de la educación como respuesta a la diversidad
Authors: Ruiz López José David
Published: December 2023

Dentro de la atención a la diversidad en los centros educativos, el trabajo con el alumnado con necesidades educativas especiales cobra especial importancia, de manera que el profesorado del programa de pedagogía terapéutica debe asumir la responsabilidad de liderar la atención a este tipo de alumnado y a sus familias, siempre en estrecha colaboración con el resto de los miembros del departamento de orientación y el profesorado del centro escolar y bajo las directrices del equipo directivo.
Application of fluorescence spectroscopy as a field method in the determination of varietal differences after tomato harvesting
Authors: MASHEVA Veselina , SLAVOVA Vanya
Published: December 2023

The study’s purpose is to establish the application based on fluorescence spectroscopy as a field method in the determination of varietal differences after tomato harvesting. The tomato fruits will be compared to determine the spectral distribution due to the varietal differences of a particular genotype. This will allow the approach to be practiced non-invasively in the quality control of tomato production in unspecified rooms and outdoors.The experimental studies have been conducted locally at the Institute of Plant Genetic Resources “K. Malkov” - Sadovo for three varieties.The spectral installation for the generation of emission fluorescence spectra is mobile. In its adjustment (optical adjustment), a system engineering approach based on the classical principles of modern optoelectronics was applied. The results of the experiment can be used to optimize the time for the analysis of the varietal difference of tomato genotypes after harvesting, under uncontrolled conditions. This will support the process of determining the belonging of a specific аccession to a given variety (even for аccessions of unknown origin) when it is necessary to qualify a score of samples in a short time.
Transforming the Subaltern Voices of the Global World
Authors: Nellas Suzette
Published: December 2023

The purpose of this article is to highlight the significance of an encounter culture from the standpoint of globalization as a major challenge to modern evangelization. It turns out that the missiological concept of dialogue can act as a catalyst for the transformation and restoration of the dignity of people living on the periphery of modern societies. Dialogue of life and action as one of the tools of evangelization and promotion of good can lead to the formation of structurally stable societies rooted in the Gospel.
The impact of the crusade ideas in Western Pomerania (from the twelfth to the first quarter of the thirteenth century )
Authors: Wasilkiewicz Kamil
Published: December 2023

The paper outlines the impact of the crusade ideas in Western Pomerania from the twelfth to the end of the first quarter of the thirteenth century, showing how it affected the region in three essential stages. The Western Pomeranians – attached to a traditional, native belief system – first encountered the crusade movement in the first half of the twelfth century, initially as its victims. Subsequently, the crusade ideas spread among the Western Pomeranian knights in the second half of the twelfth century as an element of the new, Christian culture. In the third stage, the region’s inhabitants became directly involved in the Fifth Crusade. In keeping with the historical methodology, the study is an attempt at a new, more comprehensive approach to the propagation of the crusade ideas in Western Pomerania and its effect on the locals. Also, the findings demonstrate that further research into the issue would be highly recommended.
Археологічні пам’ятки Любеча
Authors: Веремейчик Олена
Published: December 2023

The archaeological heritage of Liubech (Lyubech, Chernihiv region, Ukraine) includes various monuments and objects from the Bronze Age to early Modernity (2000 BC – 17th century) with small time gaps. Archaeological surveys in Liubech began in the late 19th century and have continued until today with certain interruptions. Despite the close attention paid by scholars to the archaeological monuments of Liubech, it should be noted that the area of the city within its administrative boundaries (both the floodplain part of the Dnieper River and the densely developed part of the town) has not been sufficiently studied.
Verificação de modelo computacional para placas com enrijecedores do tipo viga-caixão submetidas à carga transversal uniformemente distribuída
Authors: Alvarenga Alves Mariana , Machado Rodrigues Eduarda , Camargo Vieira Diulia , Torres Pinto Vinícius , Oliveira Rocha Luiz Alberto , Domingues dos Santos Elizaldo , André Isoldi Liércio
Published: December 2023

A utilização de modelos computacionais para avaliar o comportamento mecânico em estruturas de aço é amplamente difundida para aplicações acadêmicas e comerciais/industriais. Este trabalho propõe um modelo numérico desenvolvido no software ANSYS Mechanical APDL, que é baseado no Método dos Elementos Finitos, para analisar a deflexão de placas de aço com enrijecedores do tipo viga-caixão com formato trapezoidal, também conhecidas como hat-stiffened plates. O objetivo deste estudo é verificar o modelo computacional proposto, que emprega o elemento finito do tipo SHELL281, comparando seus resultados com os de dois estudos anteriores que adotam elementos finitos tipo SHELL63, SHELL93, SHELL181 e/ou BEAM3, analisando o comportamento mecânico das placas em termos da deflexão máxima na estrutura. Para isso, dois estudos de caso encontrados na literatura foram aqui reproduzidos. A diferença máxima encontrada em relação aos resultados da literatura para o estudo de caso 1 foi de 1,40% para uma placa simplesmente apoiada; já o estudo de caso 2 apresentou uma diferença média de 3,30% para a placa simplesmente apoiada e 2,43% para a placa engastada. Portanto, a partir destes resultados foi possível considerar o modelo computacional proposto como devidamente verificado.
Product Differentiation and Trade
Authors: Pi Jiancai , Fan Yanwei
Published: December 2023

This paper analyzes the impacts of product differentiation in general oligopolistic equilibrium with trade. With constant wages, when product differentiation increases, the extensive margins of home and foreign exports decrease, and the domestic and foreign scopes of variety in each industry increase unambiguously. However, the impact of product differentiation on the labor requirement of each firm is mixed. In general equilibrium, an increment of product differentiation increases the wage rate unambiguously if the total variety of goods is large enough in all industry. However, if all firms are single-product ones, an increment of product differentiation increases the wage rate unambiguously in general equilibrium.
Image Acts of the Virgin of Vladimir
Authors: Yu Runsheng
Published: December 2023

The Virgin of Vladimir is one of the most historically, artistically, and religiously significant icons in Russia. From an art historical perspective, it belongs to the category of Eleusa icons, using vivid depictions of the mother-child relationship to convey religious doctrine. It represents the highest level of 12th-century Byzantine and Russian religious art. From the perspective of image act, this icon’s pluralistic nature challenges the conventional notion of a work of art having a singular and authentic identity, as well as the idea of aesthetic contemplation. The icon’s mobile characteristics not only explain various miracle legends associated with icons but also provide insights into image act theory. Furthermore, analyzing the image act of this icon can contribute to a deeper understanding of the theories proposed by Bredekamp, distinguishing between passive act in non-autonomous images and active acts in autonomous images.
Association of ITPA 94C>A genetic polymorphisms with azathioprine induced adverse effects in the South Indian population
Authors: Deva Reka , Rajendran Priyadharsini , Ramasamy Sivaranjini , Selvan Senthamizh , Ramasamy Kesavan
Published: December 2023

Objectives

Azathioprine (AZA) is an effective immunosuppressant commonly used for malignancy and immune-mediated disorders. The association between genetic polymorphisms and AZA-induced adverse effects has not been elucidated. Hence this study aimed to evaluate the relationship between single nucleotide polymorphisms of ITPA (C94A) with azathioprine-induced adverse effects.

Methods

A cross-sectional study was performed on 120 patients who were on AZA therapy for immunobullous disorders and inflammatory bowel disease (IBD). Eligible patients were enrolled from outpatient Departments of dermatology and medical gastroenterology and five mL of blood was collected after obtaining written informed consent. DNA extraction and genotyping were done by phenol–chloroform method and real-time polymerase chain reaction (RT-PCR), respectively.

Results

The minor allele frequency of ITPA (A allele) was 30.8 %. The mutant genotypes of ITPA (C94A) were found to have no significant association with overall adverse effects in the South Indian patients on AZA therapy.

Conclusions

We report no significant association between ITPA rs1127354 genetic polymorphism and adverse effects in the South Indian patients on AZA therapy.
The optimization of hydrogel strength from cassava starch using oxidized sucrose as a crosslinking agent
Authors: Kayati Fitri Nur , Purnomo Chandra Wahyu , Kusumastuti Yuni , Rochmadi
Published: December 2023

The mechanical properties of hydrogels are crucial in wound dressing application. Starch-based hydrogels have deficiencies in mechanical strength and gel stability. These shortcomings can be addressed by employing crosslinking techniques with oxidized sucrose. A design of experiments approach was used to optimize the tensile strength of the product. The results indicated that both the composition of oxidized sucrose and glycerol significantly impact tensile strength (p-value < 0.05). The optimal tensile strength achieved was 27 MPa, using 0.9762 mL of oxidized sucrose and 0.0624 g of glycerol per gram of starch. The hydrogel products underwent a series of characterizations, including optical microscope examination, Fourier Transform Infrared Spectroscopy (FTIR), Proton Nuclear Magnetic Resonance (1H NMR), swelling test, Water Vapor Transmission Rate (WVTR), contact angle, and cytotoxicity test. The FTIR and 1H NMR analyses confirmed the crosslinking of hydroxyl groups within starch molecules with aldehyde groups from oxidized sucrose. Characterization of this hydrogel revealed that it had a swelling capacity of 95%, a WVTR of 714.92 g per m2 per 24 h, a contact angle of 74.76°, and a cell viability value greater than 100%. Thus, this hydrogel is suitable for wound dressing due to its strength, exudate-absorbing capabilities, moisture retention properties, hydrophilicity, and non-toxicity.
The Chaîne Opératoire Approach for Interpreting Personal Ornament Production: Marble Beads in Copper Age Tuscany (Italy)
Authors: Vassanelli Alice , Petrinelli Pannocchia Cristiana , Starnini Elisabetta
Published: December 2023

This article discusses the chaîne opératoire concept in prehistoric archaeology, traditionally employed for the study of lithic industries and ceramic production, and focuses on personal ornament manufacture. This category of non-functional objects has been analysed with the operational sequence approach in the framework of a research project aimed at the techno-functional study of prehistoric marble artefacts. Throughout an experimental approach, the study presents the actions and choices made by the artisans to produce marble beads and tries to understand the role and social-cultural meaning that these items had for the Copper Age communities in Tuscany. Finally, our study proved that the beginning of the use of the Apuan marble can be traced back to the sixth millennium BC, and it was connected with the production of personal ornaments, reaching its peak during the Copper Age.
What is long-term survival in patients with peritoneal metastasis from gastric, pancreatic, or colorectal cancer? A study of patients treated with systemic chemotherapy and pressurized intraperitoneal aerosol chemotherapy (PIPAC)
Authors: Kryh-Jensen Charlotte G. , Fristrup Claus W. , Ainsworth Alan P. , Detlefsen Sönke , Mortensen Michael B. , Pfeiffer Per , Tarpgaard Line S. , Graversen Martin
Published: December 2023

Objectives

A definition of long-term survival (LTS) in patients with peritoneal metastasis (PM) from gastric cancer (GC), pancreatic cancer (PC) or colorectal cancer (CRC) treated with systemic chemotherapy and pressurized intraperitoneal aerosol chemotherapy (PIPAC) is lacking. We aimed to define LTS and investigate characteristics and treatment response in patients who reached LTS in data from two prospective trials.

Methods

Retrospective study of patients with GC-, PC-, or CRC-PM from the prospective PIPAC-OPC1 and PIPAC-OPC2 studies. The definition of LTS was based on published systematic reviews and randomized controlled trials. LTS was defined at the time point where 25 % of the patients were alive in these studies. Histology based response was evaluated by the mean Peritoneal Regression Grading Score (PRGS) using biopsies obtained prior to PIPAC 3, and defined by a mean PRGS of ≤2.0 or a decrease of mean PRGS of ≥1, compared to baseline.

Results

LTS was defined at 21 (GC), 15 (PC), and 24 (CRC) months. Fifty-one (47.2 %) patients (nine GC, 17 PC, 25 CRC) reached LTS calculated from the date of PM diagnosis. All but one received palliative chemotherapy before PIPAC, and 37 % received bidirectional treatment. More than 90 % of the LTS patients had response according to PRGS. The mOS from PIPAC 1 was 23.3, 12.4, and 28.5 months for GC, PC, and CRC LTS patients.

Conclusions

Patients with PM from GC, PC, and CRC treated with systemic chemotherapy and PIPAC can reach LTS and most show histological response. Causality must be further investigated.
Green bonds as a tool for sustainable development of the EU’ oil and gas companies
Authors:   Primakov National Research Institute of World Economy and International Relations, Russian Academy of Sciences, Seminog Artem
Published: December 2023

In recent years, green bonds have become an increasingly attractive financial instrument for companies that shape their strategies in accordance with sustainable development. In this regard, the purpose of this study was to analyze the use of this tool by EU oil and gas companies facing challenges on the way to transition to eco-friendly production in view of the specifics of the industry that pollutes the environment. It was revealed that green bonds are more profitable for issuers compared to classic securities issued to finance projects. Also, their release has a positive effect on the competitiveness of companies, in particular, by attracting environmental investors. Green bonds are most successfully used by European oil and gas companies, which are distinguished by high quality of information disclosure. In addition, green bonds contribute to the entry of EU oil and gas companies into new markets through the implementation of environmental projects in new territories.
Relations between Sofia and Moscow against the background of domestic political processes in Bulgaria
Authors:   Primakov National Research Institute of World Economy and International Relations, Russian Academy of Sciences, Podchasov Nikolay
Published: December 2023

The article analyses the development of Russian-Bulgarian relations after February 24, 2022. The author draws attention to the fact that in the post-socialist period Sofia has developed a practice of viewing bilateral relations with Moscow not as an independent direction of foreign policy, but as a secondary part of a more general task of integrating the country into Euro-Atlantic community. Because of that the reaction of the Bulgarian political mainstream to the beginning of a special military operation of the Russian armed forces in Ukraine does not represent anything fundamentally new, but rather looks like a logical development of the traditions of Bulgarian diplomacy of recent decades. At the same time, the article emphasizes the presence of political players in Sofia who are interested in adjusting the course of Bulgarian-Russian relations by reducing their dependence on ideological and geopolitical factors.
Formation of the government in Montenegro
Authors:   Institute of Europe, RAS, Kandel Pavel
Published: December 2023

This article examines the protracted and controversial process of government formation in Montenegro in the aftermath of the presidential (19.03–02.04.2023) and early parliamentary elections (11.06.2023), although their results had already indicated who won, who lost. The problems revealed during the negotiations between the candidates for participation in power, which clearly characterize the mores of the subjects of the political scene of the country and the prospects of the new cabinet, are analyzed. Its structure and program are considered. The balance of power in the parliament is correlated with the sentiments of citizens revealed by polls. The forecast of Montenegro’s foreign policy orientation under the new government and the likelihood of its early admission to the EU are given. It was stated that normalization of relations with Serbia is possible, but in any case, no change in the general anti-Russian vector of foreign policy should be expected.
European Union and Middle East crisis 2023: between values and pragmatism
Authors:   Institute of Europe, RAS, Shumilin Alexander
Published: December 2023

The article examines the features of the Middle East policy of the European Union regarding the confrontation between Israel and the extremist organization Hamas in the Palestinian Gaza Strip. It is emphasized that such a large-scale and bloody confrontation between the mentioned antagonists is happening for the first time: until now, the clashes have been limited and shortlived. Due to the traditionally high sensitivity of the Palestinian problem for European societies (primarily as a stigmatization of the thesis about the «historical injustice of Europeans towards the Palestinian Arabs»), Brussels’ position in situations of aggravation of relations between Israel and Hamas was almost always formulated as equidistant from the conflicting parties, limited to calls for reconciliation. This time, much is different: after the brutal Hamas terrorist attack on Israeli territory on October 7, 2023, the EU leadership condemned the Islamist atrocities and reaffirmed Israel’s right to defense. Later, however, this position began to undergo a transformation towards traditional balance. The article examines the reasons and parameters of disagreements between the political elites of a number of EU countries on this issue, as well as conflict situations within the leading institutions of the European Union.
Development of the Alpha Rhythm Is Linked to Visual White Matter Pathways and Visual Detection Performance
Authors: Caffarra Sendy , Kanopka Klint , Kruper John , Richie-Halford Adam , Roy Ethan , Rokem Ariel , Yeatman Jason D.
Published: December 2023

Alpha is the strongest electrophysiological rhythm in awake humans at rest. Despite its predominance in the EEG signal, large variations can be observed in alpha properties during development, with an increase in alpha frequency over childhood and adulthood. Here, we tested the hypothesis that these changes in alpha rhythm are related to the maturation of visual white matter pathways. We capitalized on a large diffusion MRI (dMRI)-EEG dataset (dMRIn = 2,747, EEGn = 2,561) of children and adolescents of either sex (age range, 5–21 years old) and showed that maturation of the optic radiation specifically accounts for developmental changes of alpha frequency. Behavioral analyses also confirmed that variations of alpha frequency are related to maturational changes in visual perception. The present findings demonstrate the close link between developmental variations in white matter tissue properties, electrophysiological responses, and behavior.
Izazovi u provođenju online nastave za vrijeme pandemije Covid-19: Perspektiva šest europskih zemalja
Authors: Dadić Fruk Lorena
Published: December 2023

Online nastava može pružiti nastavnicima i studentima mnogobrojne koristi ako se poznaju alati, tehnike i metode u njezinu provođenju. Zbog situacije uzrokovane pandemijom virusa COVID-19, nastavnici su sve aktivnosti u vrlo kratkom vremenu morali prebaciti u online okruženje, neovisno o tome poznaju li i imaju li iskustva s poučavanjem na daljinu. Zbog toga su se nastavnici našli u nepovoljnoj situaciji i susreli se s nizom izazova koje su morali prevladati u što kraćem roku ne narušavajući kvalitetu online nastavnog procesa. Iz navedenog proizlazi cilj ovoga rada koji se ogleda u sagledavanju izazova u online nastavi za vrijeme pandemije iz perspektive visokoškolskih nastavnika iz šest europskih zemalja. U tu je svrhu od svibnja do listopada 2021. provedeno online istraživanje s pomoću strukturiranoga anketnog upitnika na uzorku od 525 nastavnika visokoobrazovnih institucija iz šest europskih zemalja. Rezultati su pokazali da se najveći izazovi s kojima se nastavnici susreću u online okruženju uglavnom odnose na provedbu ispitivanja i poznavanje rada putem određenih softvera i aplikacija. U online poučavanju nastavnicima je najizazovnije bilo studentima prenijeti znanja koja se tiču općih vještina poput sposobnosti samostalnog rada, vještina rješavanja problema, vještina prikupljanja i obrade podataka, ali i vještina koje se odnose na učenje, primjerice kako se pripremiti za predavanje te kako pisati i čitati znanstvene radove. S obzirom na širok spektar izazova s kojima su se nastavnici morali suočiti, pozitivno je da su uglavnom sve izazove mogli riješiti samostalnim pronalaženjem informacija na webu i konzultacijama s kolegama, a od velikog značaja bila im je i pomoć sveučilišta, fakulteta i tehničke službe.
The GLP-1 receptor is expressed in vivo by human metastatic prostate cancer
Authors: Stein Mark S , Kalff Victor , Williams Scott G , Murphy Declan G , Colman Peter G , Hofman Michael S
Published: December 2023

Objectives

The glucagon-like peptide-1 (GLP-1) receptor agonist, liraglutide, reduces human prostate cancer incidence, and similar GLP-1 receptor agonists reduce in vitro proliferation and in vivo growth of prostate cancer cell lines. Primary human prostate cancer expresses the GLP-1 receptor (GLP-1R) in vitro. Cancer evolves with stage, and whether advanced-stage human prostate cancer expresses GLP-1R is unknown. We hypothesised and aimed to prove that human metastatic castrate-resistant prostate cancer (mCRPC) expresses the GLP-1R in vivo. We hypothesised that mCRPC would thus be detectable by positron emission tomography/computed tomography (PET/CT) using a radiotracer bound to a GLP-1R ligand, as in exendin PET/CT.

Materials and methods

Men with mCRPC, with more than one prostate-specific membrane antigen (PSMA)-avid lesion on PET/CT scanning (pathognomic in that setting for prostate cancer lesions), were approached to undergo PET/CT with gallium68-Dota-exendin-4. We documented PET/CT PSMA-avid lesions, which were also PET/CT exendin avid, as evidence of in vivo GLP-1R expression.

Results

Out of the 24 men referred, three did not meet the inclusion criteria. Seventeen declined, largely because the study offered them no therapeutic benefit. Among the four men imaged, three had no exendin-avid lesions, while one had six osseous PSMA-avid lesions, three of which were also exendin avid.

Conclusions

We demonstrated in vivo GLP-1R expression by human mCPRC, detecting PET/CT lesions avid for both PSMA and exendin, in one of four participants. GLP-1R expression may thus occur even in advanced-stage prostate cancer. Our data contribute to growing evidence supporting the testing of GLP-1 receptor agonists for therapeutic benefit in prostate cancer.
La gestión académico-pedagógica: Una mirada desde la satisfacción personal y el desarrollo humano
Authors: Pino Montoya José Wilmar , Álvarez Gallego Mónica María , Peláez Henao Oscar Alberto , Castaño Gómez Melina
Published: December 2023

La investigación tiene por objetivo reconocer la incidencia del desarrollo humano como estrategia pedagógica para fortalecer los procesos académicos de las instituciones educativas. El paradigma es interpretativo, desde el enfoque cualitativo; la estrategia es documental. Los hallazgos arrojaron como resultado que el desarrollo humano, de los docentes participantes del estudio, son un factor determinante para ayuda a mejorar los procesos académicos pedagógicos de la institución, ya que este los dota de las competencias para que los estudiantes perciban en ellos un ejemplo, un apoyo y una persona en la que pueden confiar. Como conclusión de evidencia, la satisfacción personal es un componente relevante del desarrollo humano, pues esta lleva a los docentes a sentirse felices, ajusto en su trabajo, lo que se observa en una actitud más abierta, conciliadora, responsable, ética y creadora de los docentes, convirtiéndose su propio ser en una estrategia pedagógica motivadora que facilita el proceso de aprendizaje de los estudiantes.
¿Clases sociales en la clase?
Authors: Unás Camelo Viviam Stella , Satizabal Reyes Melania
Published: December 2023

Este artículo explora la manera en que las diferencias de clases sociales participan de las interacciones que docentes y estudiantes establecen en el aula. Se realizó una investigación cualitativa, a través de entrevistas en profundidad a un grupo de docentes de instituciones públicas y privadas de la ciudad de Cali. En concreto, se examinó el modo en que este grupo de docentes interpreta su posición de clase, la de sus estudiantes y las tensiones que estas posiciones diferenciadas suponen para el desarrollo del trabajo educativo. El estudio identificó tres tensiones: primero, el desafío de concebir a la Escuela como un dispositivo de movilidad social en regímenes de estratificación que, como el colombiano, presentan una movilidad restringida; el segundo, el reto de alimentar el entusiasmo respecto al trabajo educativo en contextos en los que se atribuye a los estudiantes un bajo capital ambicioso; por último, los efectos que el origen de clase de los estudiantes tiene sobre el estatuto y contenido del trabajo docente.  A modo de conclusión, es notable el hecho de que para los docentes entrevistados la Escuela se presenta como una institución incapaz de revertir el régimen de distribución de las expectativas que las clases sociales instauran.
El ethos del maestro en la paradoja de la inclusión
Authors: Vallejo Merino Isabel Cristina , Álvarez Bahena Eyesid , Viveros Chavarría Edison
Published: December 2023

El artículo es derivado de la investigación Narrativas de estudiantes, padres de familia, docentes y directivos acerca de procesos de inclusión-exclusión educativa en estudiantes de extraedad en la Institución Educativa Monseñor Francisco Cristóbal Toro de la ciudad de Medellín, Colombia, durante la pandemia por COVID 19. En este sentido, este texto tiene como intención, problematizar el discurso de la inclusión en el contexto educativo desde la teoría sociológica de la reproducción que plantean autores como Bourdeau y Francoi Dubet y desde algunos postulados filosóficos de la teoría kantiana. Se sostiene a modo de tesis que los procesos de inclusión y exclusión al interior de la escuela no son ajenos a los procesos de desigualdad que se tejen en la sociedad, de ahí la dificultad de poner en práctica el discurso legal de la inclusión y la necesidad de volver la mirada sobre esta, como una apuesta ética del maestro.
İŞKENCENİN ÖNLENMESİ BAĞLAMINDA HUKUKUN ÜSTÜNLÜĞÜ VE AHLAK İLİŞKİSİ
Authors: ÜNÜVAR Güneş Atay
Published: December 2023

Lon L. Fuller'a göre hukuk, ancak insanları kendi düzenine tabi kılabilecek durumdaysa hukuk olabilir.

Bunu başarabilmek için hukuk, kişileri genel kurallar aracılığıyla yönetmeli ve bu kurallar ilan edilmiş,

anlaşılabilir, ileriye dönük, birbiriyle uyumlu, uygulanabilir, istikrarlı olmalı ve resmi işlemler ile ilan edilen

kurallar arasında bir örtüşme bulunmalıdır. Hukukun üstünlüğünün prensipleri olarak kabul edilen bu

sekiz ilke bir düzeni hukuk sistemine dönüştürmek için olmazsa olmazdır. Hukukun üstünlüğü, Fuller'ın

görüşünde, kişileri haysiyet sahibi failler olarak değerlendirdiğinden ve keyfi yönetimlerin ahlaki talepleri

ihlal etmeye yönelik uygulamalarını sınırlayabileceğinden ahlaki bir değer taşır. Hukuki pozitivistler ise bu

prensiplerle etik arasında zorunlu bir ilişki kurulamayacağını ileri sürerek hukukun üstünlüğünü araçsal bir

konuma indirgerler. Bu çalışmada ilk olarak Fuller'ın prosedürel doğal hukuk teorisiyle pozitivistlerin karşı

argümanları değerlendirilmekte, daha sonra Bush yönetiminin soruşturmalarda işkence yöntemleri

kullanabilmesinin ancak Fuller'ın ortaya koyduğu prensiplerin ihlali ile mümkün olduğu ortaya konarak

hukukun üstünlüğünün işkencenin önlenmesi bağlamında ahlaki değeri haiz olduğu savunulmaktadır
Velázquez's "Bodegones" and the Art of Emulation
Authors: Tiffany Tanya J.
Published: December 2023

Este ensayo explora el concepto de la imitación artística en el Siglo de Oro español a través de un análisis de los bodegones de Velázquez. Los historiadores del arte italiano y francés han reconocido desde hace mucho tiempo que la invención artística en el siglo XVII se basaba en gran parte en la emulación, por la cual los artistas competían con los maestros antiguos y modernos a través de la apropiación selectiva de aspectos de sus obras. Utilizando los escritos de los biógrafos tempranos de Velázquez, este ensayo propone a la emulación como marco histórico para considerar la innovación en el joven Velázquez a la vez que su implicación en las tradiciones artísticas de su tiempo. El examen de los bodegones también aclara el reto de Velázquez a Caravaggio, al adoptar y adaptar el estilo del italiano en sus escenas de la vida cotidiana, vertidas en un potente claroscuro y con agudas alusiones a fuentes literarias.
La restauración del Palacio Arzobispal de Alcalá de Henares en el siglo XIX
Authors: Llull Peñalba Josué
Published: December 2023

En este artículo se propone un análisis sistemático de las obras de restauración monumental que se desarrollaron en el Palacio Arzobispal de Alcalá de Henares durante el siglo XIX, con el fin de convertirlo en sede del Archivo General Central. Primeramente se hace una descripción de los principales elementos y del proceso constructivo de este singular edificio, poniendo especial atención en el Salón de Concilios. A continuación se valora el estado de conservación en que se hallaba su arquitectura a mediados del siglo XIX. Finalmente se analiza cada una de las etapas del proceso de rehabilitación, deteniéndose en las intervenciones más significativas.
La ficción distópica de Gregor Schneider
Authors: Moriente David
Published: December 2023

La juventud del artista alemán Gregor Schneider (Rheydt, 1969) no ha supuesto un obstáculo para construir durante dos décadas un inquietante universo extremadamente personal. En este microcosmos se superponen trayectos temáticos que van de lo siniestro a lo sublime, de lo cotidiano a lo extraordinario o de lo real a lo ficticio. En los últimos años, no obstante, hemos detectado un giro conceptual en el que se reflexiona de manera sistemática sobre la duplicación. A ello hay que añadir la paulatina visibilidad del trabajo de Schneider unida a un desplazamiento hacia la crítica de un espacio político cada vez más tenebroso y amenazador. En el siguiente texto, intentamos hacer un balance de la obra del artista mediante el análisis de unos pocos ejemplos: Haus u r (La casa u r), Die Familie Schneider (La familia Schneider) y los proyectos cúbicos en distintos países.
Guerrilleros, bandoleros y facciosos: el imaginario romántico de la lucha marginal
Authors: Reyero Carlos
Published: December 2023

Rara vez se pone en relación a guerrilleros, bandoleros y luchadores políticos. Aunque su papel moral es diferente, por supuesto, tienen un aspecto común en el imaginario romántico: los tres parecen evidenciar una fascinación subconsciente hacia la lucha marginal, particularmente en las imágenes. Su comportamiento es interpretado como una tendencia natural por la libertad. Sin embargo, cuando los ideales románticos decaen, o cuando las imágenes tienen un uso oficial, algunos aspectos iconográficos, originariamente atractivos, cambian su significado.
El "oratorio" de al-Hakam II en la mezquita de Córdoba
Authors: Abad Castro Concepción
Published: December 2023

En este trabajo abordamos una nueva interpretación del proceso constructivo de la ampliación de al-Hakam II en la mezquita de Córdoba. Basándonos en los textos árabes, proponemos una cronología más detallada para las diferentes fases en las que se fueron configurando el "oratorio" y las "maqsuras" del califa. Finalmente, presentamos una interpretación iconográfica del tramo que precede al mihrab.
...Eppur si muove. La pintura sevillana después de la peste negra (1650-1655)
Authors: Quiles García Fernando
Published: December 2023

La peste negra tuvo un efecto muy negativo sobre la ciudad. Es un hecho reconocido. Sin embargo, apenas se ha estudiado su incidencia sobre las comunidades artísticas locales. De ahí el interés por acometer su estudio a través de un colectivo tan representativo como el de pintores
El marqués de Zenete y sus posesiones valencianas: Mentalidad arquitectónica y artística de un noble del Renacimiento
Authors: Gómez-Ferrer Lozano M. Mercedes
Published: December 2023

A partir de documentación inédita se analizan las obras que patrocinó el Marqués de Zenete (h. 1473-1523) en sus posesiones valencianas: la casa y huerto de Alcócer, el castillo de Ayora y el palacio arzobispal de la ciudad de Valencia. Se estudian tanto sus conocimientos sobre arquitectura, como también otros intereses artísticos, en especial los relativos a las obras pictóricas.
Sebastián Serlio y el virreinato de Nueva España: usos y recepción
Authors: Cuesta Hernández Luis Javier
Published: December 2023

El de Serlio, tal vez el definidor último del sistema de órdenes clásicos, que después cristalizará Viñola, fue el más importante de entre los sistemas teóricos de arquitectura que llegaron al Virreinato de la Nueva España a lo largo de su existencia. Pero, a la vista de las realizaciones prácticas a que los alarifes novohispanos llegaron a lo largo de ese periodo ¿podemos realmente hablar de un sistema teórico de arquitectura? En este artículo esperamos poder arrojar algo de luz sobre la oposición de dos formas distintas de entender el mundo, en este caso, desde el imaginario arquitectónico: el relato escrito que constituyen los textos teóricos que llegaron hasta el virreinato; y las obras construidas en definitiva. Este artículo estudiará las huellas de Serlio en Nueva España. Al presentar estas fuentes esperamos poder mostrar los diferentes usos y tipos de recepción que la arquitectura virreinal tuvo para con la obra de Serlio Boloñés.
Diego de Urbina (1516-1595): Pintura y mecenazgo antes de 1570
Authors: Collar de Cáceres Fernando
Published: December 2023

La dilatada labor pictórica desarrollada por Diego de Urbina (1516-1595) con anterioridad a 1569 se nos ha mostrado hasta ahora esquiva por la pérdida o destrucción de buena parte de su obra. El presente artículo viene a dotar de contenido a un periodo extenso y esencial de su trayectoria en el que ocupa un lugar primordial el capítulo de su trabajo al servicio de don Pedro Álvarez Acosta, obispo de Osma.