bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk factors for developing chronic whiplash disorders
Authors: Nedić Dalibor , Pilija Vladimir
Published: August 2021

BACKGROUND: Whiplash injury is one of the most common injuries in traffic accidents. Most of the injured recover within three months, however, a significant number have symptoms much longer. OBJECTIVE: The aim of this study was to determine the basic epidemiological characteristics of whiplash (gender, age, collision type, the type of participants in an accident, clinical signs) on Bosnia and Herzegovina roads and identify risk factors for chronic symptoms. METHODS: The subjects of this retrospective study were traffic accident whiplash patients who were diagnosed, treated and monitored in a single hospital center. The initial examination was performed on the day or the day after the accident and follow-up examinations after four weeks, three months, and six months. RESULTS: Out of the 241 patients in this study, 14.1% had symptoms over six months after the trauma. 54.7% of the injured belong to the third and fourth decade and close to 80% were younger than 50 years. In addition to neck pain, the most common symptoms were limited neck mobility (69.7%), muscle spasms (63.5%), palpable pain of neck muscles (56%), headache (43.6%), nausea (23.7%). Statistical analysis showed a positive impact of age, Quebec Task Force (QTF) grade II, and more injury severity and cervical spine degenerative changes on prolonged recovery. CONCLUSIONS: The overwhelming majority of the injured belong to the working population. QTF2+ score is a useful indicator for prolonged recovery and chronic symptoms. Age, QTF score and degenerative changes of the cervical spine indicate an increased risk for poor recovery and chronic symptoms.
Identification of potential prognostic markers associated with lung metastasis in breast cancer by weighted gene co-expression network analysis
Authors: Zhang Xixun
Published: August 2021

Breast cancer (BC) is an aggressive cancer with a high percentage recurrence and metastasis. As one of the most common distant metastasis organ in BC, lung metastasis has a worse prognosis than that of liver and bone. Therefore, it’s important to explore some potential prognostic markers associated with the lung metastasis in BC for preventive treatment. In this study, transcriptomic data and clinical information of BC patients were downloaded from The Cancer Genome Atlas (TCGA) database. Co-expression modules constructed by weighted gene co-expression network analysis (WGCNA) found the royal blue module was significantly associated with lung metastasis in BC. Then, co-expression genes of this module were analyzed for functional enrichment. Furthermore, the prognostic value of these genes was assessed by GEPIA Database and Kaplan-Meier Plotter. Results showed that the hub genes, LMNB and CDC20, were up-regulated in BC and had a worse survival of the patients. Therefore, we speculate that these two genes play crucial roles in the process of lung metastasis in BC, which can be used as potential prognostic markers in lung metastasis of BC. Collectively, our study identified two potential key genes in the lung metastasis of BC, which might be applied as the prognostic markers of the precise treatment in breast cancer with lung metastasis.
Cognitive Effects of the BET Protein Inhibitor Apabetalone: A Prespecified Montreal Cognitive Assessment Analysis Nested in the BETonMACE Randomized Controlled Trial
Authors: Cummings Jeffrey , Schwartz Gregory G. , Nicholls Stephen J. , Khan Aziz , Halliday Chris , Toth Peter P. , Sweeney Michael , Johansson Jan O. , Wong Norman C.W. , Kulikowski Ewelina , Kalantar-Zadeh Kamyar , Lebioda Kenneth , Ginsberg Henry N. , Winblad Bengt , Zetterberg Henrik , Ray Kausik K.
Published: August 2021

Background: Epigenetic changes may contribute importantly to cognitive decline in late life including Alzheimer’s disease (AD) and vascular dementia (VaD). Bromodomain and extra-terminal (BET) proteins are epigenetic “readers” that may distort normal gene expression and contribute to chronic disorders. Objective: To assess the effects of apabetalone, a small molecule BET protein inhibitor, on cognitive performance of patients 70 years or older participating in a randomized trial of patients at high risk for major cardiovascular events (MACE). Methods: The Montreal Cognitive Assessment (MoCA) was performed on all patients 70 years or older at the time of randomization. 464 participants were randomized to apabetalone or placebo in the cognition sub-study. In a prespecified analysis, participants were assigned to one of three groups: MoCA score≥26 (normal performance), MoCA score 25–22 (mild cognitive impairment), and MoCA score≤21 (dementia). Exposure to apabetalone was equivalent in the treatment groups in each MoCA-defined group. Results: Apabetalone was associated with an increased total MoCA score in participants with baseline MoCA score of≤21 (p = 0.02). There was no significant difference in change from baseline in the treatment groups with higher MoCA scores. In the cognition study, more patients randomized to apabetalone discontinued study drug for adverse effects (11.3% versus 7.9%). Conclusion: In this randomized controlled study, apabetalone was associated with improved cognition as measured by MoCA scores in those with baseline scores of 21 or less. BET protein inhibitors warrant further investigation for late life cognitive disorders.
Chronic Kidney Disease Associated with Worsening White Matter Disease and Ventricular Enlargement
Authors: Vemuri Prashanthi , Davey Cynthia , Johansen Kirsten L. , Zuk Samantha M. , Reid Robert I. , Thostenson Kaely B. , Reddy Ashritha L. , Jack Clifford R. , Knopman David S. , Murray Anne M.
Published: August 2021

Background: Chronic kidney disease (CKD), a growing public health issue in the elderly, is associated with increased risk of cognitive impairment. Objective: To investigate the mechanisms through which CKD impacts brain health using longitudinal imaging. Methods: We identified 97 participants (74 CKD and 23 non-CKD) from the BRINK (BRain IN Kidney Disease), a longitudinal study of CKD with two MRI scans (baseline and 3-year follow-up). We measured the associations between baseline and change in kidney disease biomarkers of estimated glomerular filtration rate (eGFR) and urinary albumin to creatinine ratio (UACR), considered a measure of microvascular inflammation, and imaging outcomes of cortical thickness and ventricular volume from structural MRI, white matter hyperintensities (WMH) volume from FLAIR images, and fractional anisotropy of the corpus callosum (FACC). Results: There were white matter-specific changes as observed by increased WMH volume and decreased FACC in CKD participants, as well as ventricular volume increase in both CKD and non-CKD groups reflective of aging-related changes. Decline in eGFR was associated with decrease in the FACC, suggesting that subtle early white matter changes due to kidney disease can be captured using DTI. An increase in UACR was associated with increase in ventricular volume. Conclusion: Our results support the role of eGFR as a measure of kidney microvascular disease which is associated with concurrent white matter damage in CKD. Future work is needed to investigate the possible link between endothelial microvascular inflammation (as measured by an increased UACR) and ventricular volume increase.
Optimization of cogging torque in permanent magnet motors based on parameter sensitivity and Kriging model
Authors: Liu Chengwu , Wu Ming , Wu Ping , Zhu Zhiliang
Published: August 2021

The weakening of cogging torque in permanent-magnet synchronous motors brings about the problem of low efficiency optimization. To solve this problem, an optimization-simulation scheme for the response surface model based on the parameter sensitivity screening is proposed. A surface-mounted motor having 12 poles and 48 slots is used to obtain the law of the influence on cogging torque caused by multiple electromagnetic parameters. Additionally, the Spearman correlation is used to analyze significant factors that affect the cogging torque. The sample is collected by an OSF optimal space filling design. A Kriging model is applied to construct the relationship between the cogging torque and significant factors, and to modify the model accuracy. The multi-island genetic algorithm is used to find an optimal solution to the cogging torque. The results show that the result of the finite element analysis after optimization only has an error of 1.5% compared with the predicted value of the pseudo model, which is 62% lower than the initial value. Therefore, the sharp reduction in cogging torque in the motor verifies the effectiveness of the optimization scheme.
Knowledge graph construction based on knowledge enhanced word embedding model in manufacturing domain
Authors: Dong Jin , Wang Jian , Chen Sen
Published: August 2021

Manufacturing industry is the foundation of a country’s economic development and prosperity. At present, the data in manufacturing enterprises have the problems of weak correlation and high redundancy, which can be solved effectively by knowledge graph. In this paper, a method of knowledge graph construction in manufacturing domain based on knowledge enhanced word embedding model is proposed. The main contributions are as follows: (1) At the algorithmic level, this paper proposes KEWE-BERT, an end-to-end model for joint entity and relation extraction, which superimposes the token embedding and knowledge embedding output by BERT and TransR so as to improve the effect of knowledge extraction; (2) At the application level, knowledge representation model ManuOnto and dataset ManuDT are constructed based on real manufacturing scenarios, and KEWE-BERT is used to construct knowledge graph from them. The knowledge graph constructed has rich semantic relations, which can be applied in actual production environment. Other than that, KEWE-BERT can extract effective knowledge and patterns from redundant texts in the enterprise, which providing a solution for enterprise data management.
Early Changes in Skeletal Muscle of Young C22 Mice, A Model of Charcot-Marie-Tooth 1A
Authors: Deres Friederike , Schwartz Stephanie , Kappes-Horn Karin , Kornblum Cornelia , Reimann Jens
Published: August 2021

Background: The C22 mouse is a Charcot-Marie-Tooth 1A transgenic model with minimal axonal loss. Objective: To analyse early skeletal muscle changes resulting from this dysmyelinating neuropathy. Methods: Histology of tibialis anterior muscles of C22 mice and wild type litter mate controls for morphometric analysis and (immuno-)histochemistry for known denervation markers and candidate proteins identified by representational difference analysis (RDA) based on mRNA from the same muscles; quantitative PCR and Western blotting for confirmation of RDA findings. Results: At age 10 days, morphometry was not different between groups, while at 21 days, C22 showed significantly more small diameter fibres, indicating the onset of atrophy at an age when weakness becomes detectable. Neither (immuno-)histochemistry nor RDA detected extrajunctional expression of acetylcholine receptors by age 10 and 21 days, respectively. RDA identified some mRNA up-regulated in C22 muscles, among them at 10 days, prior to detectable weakness or atrophy, integral membrane protein 2a (Itm2a), eukaryotic initiation factor 2, subunit 2 (Eif2s2) and cytoplasmic phosphatidylinositol transfer protein 1 (Pitpnc1). However, qPCR failed to measure significant differences. In contrast, Itm2a and Eif2s2 mRNA were significantly down-regulated comparing 21 versus 10 days of age in both groups, C22 and controls. Western blotting confirmed significant down-regulation of ITM2A protein in C22 only. Conclusion: Denervation-like changes in this model develop slowly with onset of atrophy and weakness at about three weeks of age, before detection of extrajunctional acetylcholine receptors. Altered Itm2a expression seems to begin early as an increase, but becomes distinct as a decrease later.
An overview on therapeutic role of Diferuloylmethane (Curcumin) in Azheimer’s disease and sleep disorders
Authors: Shumail Hoor , Khalid Shah , Alqahtani Taha , Algahtany Mubarak , Azhar Ud Din M. , Alqahtani Ali
Published: August 2021

Curcumin is widely used in spices in Asia. It has been widely explored for various diseases as therapeutic agent. Alzheimer’s disease (AD) is a neurodegenerative disease associated with dementia and cognitive disabilities. With the progression of disease, various changes appear in the brain cells that greatly affect the daily routine of the patient including sleep-wake disturbances. In the last few decades, extensive research has been carried out on this disease suggesting the development of non-steroidal anti-inflammatory drugs for its treatment. Since long, turmeric has been used in Asian countries as a home remedy for treating various ailments. Curcumin is an active ingredient isolated from the turmeric plant and is composed of curcuminoids. Because of its anti-inflammatory, antioxidant, anti-apoptotic and neuroprotective properties, curcumin can be safely administered to stop the progression of dementia and can be used for the development of such drugs that can reverse the neurotic damage caused by AD. This review article provides a comprehensive overview on the research carried out for AD using curcumin as active model drug.
HOMO-LUMO photosensitization analyses of coronene-cytosine complexes
Authors: Mirzaei Mahmoud , Rasouli Amir Hossein , Saedi Afsoon
Published: August 2021

Photosensitization analyses of models of (–HC = CH–)n assisted coronene-cytosine complexes assigned by Cor-n-Cyt; n varying by 0, 1, 2, and 3, were investigated in this work by performing density functional theory (DFT) calculations. The investigated models were optimized and chemical descriptors were evaluated. To achieve the goal of this work, energy levels of the highest occupied and the lowest unoccupied molecular orbitals (HOMO and LUMO) were evaluated to reach the absorption energy requirement for innovating photosensitizer (PS) compounds. The models indicated that the complex formations could help the structures to participate in interactions easier than the singular models, in which HOMO-LUMO descriptors indicated lower required absorption energy for them to increase their safety for human health level. The required absorption energies of complexes with n = 0, 1, and 2, were in ultraviolet (UV) region whereas that of complex with n = 3 was moved to visible region. In this regard, the idea of new PS compounds innovation was examined here to introduce Cor-n-Cyt complexes for possible applications in photodynamic therapy (PDT).
The impact of different medical complications on the feasibility of removing the feeding tube from infants with dysphagia
Authors: Fukatsu Hikari , Nohara Kanji , Tanaka Nobukazu , Fujii Nami , Sakai Takayoshi
Published: August 2021

PURPOSE: This study examined whether certain medical complications influence the feasibility of tube removal. METHODS: 42 subjects with dysphagia who were under the age of 2.5 years were nourished entirely through feeding tubes. Additionally, they were judged to have no aspiration. The following data about the infants were collected through a retroactive survey: age at which oral feeding training commenced, gender, and whether certain medical complications (cardiovascular, respiratory, digestive, neurological, or oral) had been present at birth. The data were analyzed to determine which type of medical complication affected the likelihood of removing the feeding tube from the infant at 3 years of age. RESULTS: Of the five medical complications examined, cardiovascular complications significantly affected the feasibility of tube removal (p = 0.049). CONCLUSION: Pediatric dysphagia patients with cardiac complications, compared to those with other complications, may take longer to transition off tube feeding.
Tele-rehabilitation of upper-extremity hemiparesis after stroke: Proof-of-concept randomized controlled trial of in-home Constraint-Induced Movement therapy
Authors: Uswatte Gitendra , Taub Edward , Lum Peter , Brennan David , Barman Joydip , Bowman Mary H. , Taylor Andrea , McKay Staci , Sloman Samantha B. , Morris David M. , Mark Victor W.
Published: August 2021

Background:

Although Constraint-Induced Movement therapy (CIMT) has been deemed efficacious for adults with persistent, mild-to-moderate, post-stroke upper-extremity hemiparesis, CIMT is not available on a widespread clinical basis. Impediments include its cost and travel to multiple therapy appointments. To overcome these barriers, we developed an automated, tele-health form of CIMT.

Objective:

Determine whether in-home, tele-health CIMT has outcomes as good as in-clinic, face-to-face CIMT in adults ≥1-year post-stroke with mild-to-moderate upper-extremity hemiparesis.

Methods:

Twenty-four stroke patients with chronic upper-arm extremity hemiparesis were randomly assigned to tele-health CIMT (Tele-AutoCITE) or in-lab CIMT. All received 35 hours of treatment. In the tele-health group, an automated, upper-extremity workstation with built-in sensors and video cameras was set-up in participants’ homes. Internet-based audio-visual and data links permitted supervision of treatment by a trainer in the lab.

Results:

Ten patients in each group completed treatment. All twenty, on average, showed very large improvements immediately afterwards in everyday use of the more-affected arm (mean change on Motor Activity Log Arm Use scale = 2.5 points, p < 0.001, d′ = 3.1). After one-year, a large improvement from baseline was still present (mean change = 1.8, p < 0.001, d′ = 2). Post-treatment outcomes in the tele-health group were not inferior to those in the in-lab group. Neither were participants’ perceptions of satisfaction with and difficulty of the interventions. Although everyday arm use was similar in the two groups after one-year (mean difference = –0.1, 95% CI = –1.3–1.0), reductions in the precision of the estimates of this parameter due to drop-out over follow-up did not permit ruling out that the tele-health group had an inferior long-term outcome.

Conclusions:

This proof-of-concept study suggests that Tele-AutoCITE produces immediate benefits that are equivalent to those after in-lab CIMT in stroke survivors with chronic upper-arm extremity hemiparesis. Cost savings possible with this tele-health approach remain to be evaluated.
Implementasi Blackbox Testing Pada Aplikasi Real-Time Thermal Video Detection (Studi Kasus Deteksi Demam/Covid-19)
Authors: Yudhistiro Kukuh , Sulaksono Aditya Galih , Pratama Aditya Hidayat
Published: August 2021

Seiring munculnya pandemi Covid-19 yang vaksinnya belum tersebar secara merata, seluruh negara di dunia khususnya Indonesia telah melakukan beberapa langkah preventif guna menghambat penyebaran virus tersebut. Salah satu tindakan awal adalah melakukan deteksi setiap orang yang keluar masuk ke dalam negeri melalui bandara maupun transportasi darat. Tindakan dini tersebut dilakukan dengan mendeteksi suhu tubuh dari warga yang melalui lokasi-lokasi keluar masuk seperti bandara udara, dan stasiun kereta api. Deteksi pada umumnya dilakukan menggunakan thermal gun berbentuk alat tembak infrared yang diarahkan ke individu yang melewati pemeriksaan. Pada riset ini dibahas rangkaian alat yang terdiri dari kamera dengan sensor thermal dimana data hasil capture akan diolah melalui perangkat lunak yang menampilkan histogram suhu bagian dada hingga kepala seseorang secara realtime. Setiap hasil capture digunakan sebagai dataset yang dapat digunakan untuk kebutuhan tracing pengunjung tempat publik. Pada riset ini akan membahas pengujian fungsional (blackbox) dari aplikasi thermal video detection pada studi kasus deteksi demam.
Perbandingan Hasil Klasifikasi Jenis Daging Menggunakan Ekstraksi Ciri Tekstur Gray Level Co-occurrence Matrices (GLCM) Dan Local Binary Pattern (LBP)
Authors: Neneng Neneng , Puspaningrum Ajeng Savitri , Aldino Ahmad Ari
Published: August 2021

Daging memiliki nilai gizi tinggi yang banyak dikonsumsi oleh manusia. Kandungan yang terdapat dalam daging meliputi protein, vitamin, mineral, lemak, dan zat lainnya yang sangat dibutuhkan di dalam tubuh sehingga dapat melaksanakan kegiatan setiap harinya. Akan tetapi sayangnya tidak semua masyarakat bisa membedakan jenis daging tersebut, dikarenakan tekstur dan warnanya yang hampir mirip. Hal ini juga kerap dimanfaatkan oleh penjual daging yang tidak bertanggungjawab dengan mencampur jenis daging tersebut atau dengan jenis daging lain untuk mendapatkan keuntungan yang besar. Padahal tidak semua orang bisa mengkonsumsi jenis daging tertentu karena alasan penyakit yang diderita.  Penelitian yang dilakukan ini membandingkan metode GLCM dan LBP untuk klasifikasi citra jenis daging berdasarkan analisis tekstur. Jenis citra daging yang diklasifikasi adalah daging kambing, kerbau, dan kuda. Data citra daging tersebut diperoleh dengan cara mengambil gambar secara manual menggunakan kamera digital yakni Nikon D3200. Citra tersebut diambil dengan jarak 20 cm. Pengujian dan pelatihan data dilakukan dengan metode Support Vector Machine (SVM). Ciri tekstur yang digunakan adalah ASM, IDM, entropi, kontras, serta korelasi. Hasil akurasi klasifikasi citra daging kambing, kerbau, dan kuda menggunakan metode GLCM adalah sebesar 75,6%. Sedangkan hasil akurasi klasifikasi menggunakan metode LBP adalah sebesar 85,6%. Dengan demikian, metode ekstraksi ciri tekstur LBP lebih direkomendasikan untuk klasifikasi jenis daging menggunakan ciri tekstur.
Lean-Exzellenz im OP Management
Authors: Angerer Alfred , Brand Tim , Gurnhofer Ines , Mattmann Oliver , Juchler Isabelle , Martens Rutger
Published: August 2021

Der OP-Bereich ist als Herzstück des Leistungsportfolios von zentraler Bedeutung für die Behandlungsqualität wie auch die wirtschaftlichen Ergebnisse des Krankenhauses. So steht auch der OP im Zentrum der Aufmerksamkeit bei der kontinuierlichen Optimierung von Prozessen und Abläufen.

Dieses Buch ist eine praxisorientierte Anleitung für die Prozessoptimierung mit der Lean Management-Methode im OP-Bereich - mit dem Ziel beste Qualität für den Patienten und reibungslose Abläufe zu kombinieren. Gute Prozesse sind nicht nur die Voraussetzung für ökonomische Effizienz, sondern auch die Basis für eine hohe Mitarbeiterzufriedenheit. Das Buch bündelt und vermittelt anwendungsorientiert das Wissen von Praktikern und Akademikern verschiedener Organisationen. Dabei steht nicht die radikale Veränderung des OPs nach dem Big-Bang-Ansatz im Mittelpunkt. Vielmehr sollen die Veränderungen Schritt für Schritt Eingang in den OP finden. Das Buch behandelt die wichtigsten Elemente einer solchen OP-Transformation:

1. Einführung in die Lean-Philosophie

2. Projektplan zur Schaffung einer Lean-Organisation und -Kultur

3. Ausführliches Wissenskompendium mit Konzepten und Werkzeugen

4. Fallbeispiele aus der Praxis

Die zahlreichen Abbildungen sowie die Arbeitsformulare im Anhang erleichtern die Umsetzung in die Praxis. Das Buch richtet sich sowohl an Mitarbeitende mit einem betriebswirtschaftlichen als auch mit einem medizinischen Hintergrund, die das Arbeiten in ihrem OP besser gestalten wollen.
Personalmanagement im Krankenhaus
Authors: Naegler Heinz , Garbsch Marlies
Published: August 2021

Fachkräftemangel, steigende Ansprüche an die Attraktivität des Arbeitsplatzes und der weiter zunehmende Wettbewerb um die besten Talente erfordern neue und bessere Strategien seitens der Führungskräfte und Personalmanager in Krankenhäusern. Sie sind gefordert, Arbeitsbedingungen zu schaffen, die den Bedürfnissen der Belegschaft sowohl nach einer bestmöglichen Behandlung der Patienten als auch nach individuellen Vereinbarungen gerecht werden, und damit eine positive Arbeitgebermarke zu entwickeln.

Work-Life-Balance, veränderte Altersstrukturen der Belegschaften, steigende Anforderungen an Qualifikation, Motivation und Effizienz, eine zunehmende Digitalisierung sowie soziale und gesundheitliche Vorsorge am Arbeitsplatz sind weitere vitale Herausforderungen für das Personalmanagement im Krankenhaus.

Das Standardwerk erscheint in der 5. Auflage umfangreich aktualisiert und um neue Schwerpunkte und aktuelle Themen erweitert.
Analyzing Complex Predicates in Karo Language using Syntactic Parsing
Authors: Tarigan Karisma Erikson , Stevani Margaret
Published: August 2021

This study characterized the complex predicate and multiple events where the multi-verb single clause realises a single event in syntax and examined the complex sentences containing multiple verbal predicates. This study used the descriptive qualitative method. The data sources used were sentences containing karo sentence clauses and was classified based on the elements of complex Predicates in a tree diagram and the RRG account of nexus-juncture relations theory by Nolan, 2005 & Van Valin, 2005. The findings showed that event, argument, and semantic could be realized in syntactic meaning to reveal complex predicates. The tightest syntactic linkages embodied the closer semantic relations and it was signaled by word order. Most of the complex predicates in Karo language have an embedded object.  The core in the nucleus could be appeared not only as one core but two or more complex predicates and it followed by an argument with the form V+V+N and in the form of V+V+N. One argument (Participant/Actor) that involved one core. It assumed that there might be one participant in two events, and there may be two participants in one event. All of Karo language sentences have at least one NP + one VP and they consisted of more than one complex predicates.
La tributación sobre la renta en Colombia
Authors: Polania Bello Wilminton Richard Harrison , Ome Barahona Anayibe , Sabí Ramírez Evelia
Published: August 2021

El presente artículo tiene por objetivo analizar los aspectos más sobresalientes del Impuesto sobre la renta, desde su nacimiento internacional y nacional hasta los acontecimientos actuales. En Colombia, es un tributo que grava la renta de las personas naturales y los beneficios de las personas jurídicas, basándose en los principios de equidad, justicia y progresividad. Nace en Inglaterra durante el siglo XVIII con el fin de financiar las guerras de expansión del imperio británico. Es acogido en Colombia durante la tercera década del siglo XIX, pocos años después se abolió, pero, en 1918 tomó de nuevo vida jurídica hasta nuestros días que permanece vigente.
Reliability of Early Ambulation after Intradural Spine Surgery : Risk Factors and a Preventive Method for Cerebrospinal Fluid Leak Related Complications
Authors: Lee Subum , Cho Dae-Chul , Kim Kyoung-Tae , Lee Young-Seok , Rhim Seung Chul , Park Jin Hoon
Published: August 2021

Objective : Cerebrospinal fluid leakage related complications (CLC) occasionally occur after intradural spinal surgery. We sought to investigate the effectiveness of early ambulation after intradural spinal surgery and analyze the risk factors for CLC.Methods : For this retrospective cohort study, we enrolled 314 patients who underwent intradural spinal surgery at a single institution. The early group contained 79 patients who started ambulation after 1 day of bedrest without position restrictions, while the late group consisted of 235 patients who started ambulation after at least 3 days of bed rest and were limited to the prone position after surgery. In the early group, Prolene 6–0 was used as the dura suture material, while black silk 5–0 was used as the dura suture material in the late group.Results : The overall incidence rate of CLC was 10.8%. Significant differences between the early and late groups were identified in the rate of CLC (2.5% vs. 13.6%), surgical repair required (1.3% vs. 7.7%), and length of hospital stay (2.99 vs. 9.29 days) (p<0.05). Logistic regression analysis revealed that CLC was associated with practices specific to the late group (p=0.011) and the revision surgery (p=0.022).Conclusion : Using Prolene 6–0 as a dura suture material for intradural spinal surgery resulted in lower CLC rates compared to black silk 5–0 sutures despite a shorter bed rest period. Our findings revealed that suture - needle ratio related to dura defect was the most critical factor for CLC. One-day ambulation after primary dura closure using Prolene 6–0 sutures appears to be a cost-effective and safe strategy for intradural spinal surgery.
Avaliação do tratamento integrativo no controle de parasitas gastrintestinais de ovinos
Authors: Pereira Jairo Edésio Gonçalves , Pereira Michelli , Magalhães Rebeca Gonçalves de Lima , Melotti Ricardo Passamani , Rizzomi Leandro Becalete , Guedes Elizângela , Garcia José Antônio Dias
Published: August 2021

Um dos principais entraves para o crescimento do rebanho ovino são as perdas ocasionadas pelas helmintoses gastrintestinais. Deste modo, o presente estudo teve como objetivo avaliar o efeito de dois tratamentos antiparasitários para ovinos infectados naturalmente, usando um tratamento alopático Cloridrato de Levamisol 5% e um tratamento homeopático com o produto Homeocapriovi Verm 100, comparando as diferenças da contagem de ovos por grama de fezes (OPG) e oocistos por grama de fezes (OOPG) dos tratamentos e as concentrações séricas de proteínas totais, globulinas, albumina e a relação albumina/globulina dos tratamentos alopático e o homeopático na resposta imunológica frente às infecções parasitárias.  Após análise dos resultados, tanto o produto alopático quanto o produto homeopático utilizado neste estudo preveniram o aumento de OPG para infecção por helmintos da ordem Strongylida e ambos os grupos não manifestaram sinais clínicos de coccidiose. Não houve diferença significativa entre os dois grupos na análise da média da concentração sérica das proteínas totais, albumina, globulina e a relação albumina/globulina. Embora o custo tenha sido mais elevado no tratamento homeopático, pode-se concluir que, o mesmo é uma alternativa eficiente no controle de parasitas do trato gastrintestinal de ovinos.
Reconhecimento dos sinais e sintomas e dos fatores de risco do acidente vascular cerebral por leigos: uma revisão integrativa
Authors: Moita Sued Magalhães , Cardoso Andressa Nogueira , Guimarães Ingred Pimentel , Rodrigues Karine Souza , Gomes Manoelise Linhares Ferreira , Amaral Vitória Ferreira do , Pinto Francisco José Maia , Linard Cybelle Façanha Barreto Medeiros
Published: August 2021

Objetivo: Investigar o nível de conhecimento dos leigos acerca da identificação dos sinais e sintomas e dos fatores de risco referentes ao AVC. Materiais e métodos: Foi realizada pesquisa bibliográfica em bases de dados internacionais, sendo selecionados 9 estudos publicados entre os anos de 2017 e 2021, compreendendo os idiomas inglês e português. Resultados: Ao analisar os artigos elencados, percebeu-se que a maioria fez uso de questionário como instrumento de coleta de dados (88,9%) e entrevistas presenciais (66,7%). Com relação aos sinais e sintomas, os principais abordados pelos estudos foram: fraqueza ou formigamento na face, no braço ou na perna; confusão, alteração da fala ou compreensão da linguagem; alteração na visão e dor de cabeça súbita, intensa e sem causa aparente. Quanto aos fatores de risco, os mais abordados foram hipertensão e tabagismo. Conclusões: Percebeu-se que o nível de conhecimento dos leigos acerca da identificação dos sinais e sintomas e fatores de risco do AVC não é satisfatório, devido ao baixo nível educacional dos participantes, poucas campanhas educativas e diminuto vínculo entre os usuários e as equipes interdisciplinares de saúde.
Physicochemical, antioxidant and sensory properties of Kombucha beverages obtained from oolong or yerba mate tea fermentation
Authors: Tsuru Vitor Hugo , Gomes Rodrigo José , Silva José Renato , Prudencio Sandra Helena , Costa Giselle Nobre , Spinosa Wilma Aparecida
Published: August 2021

Kombucha is a non-alcoholic fermented beverage traditionally produced from a sugared tea that presents a sour and refreshing taste This work aimed to develop, characterize and evaluate the sensory acceptance of Kombucha beverages made from oolong, a traditionally tea used for Kombucha production, or yerba mate tea, which is very popular and easily found herb in Brazil. The characterization was related total soluble solids (TSS), sugars, pH, titratable acidity (TA), organic acids (OA), alcohol content (AC), phenolics (PHE), flavonoids (FL), antioxidant activity (AA), besides, the sensory acceptance by potential consumers. Total soluble solids decreased 8.3% in formulation with oolong and 7.0% in formulation with yerba mate tea. The pH ranged from 4.3 and 4.5 to 2.8 and 3.1 after 14 days, respectively. Titratable acidity reached 8.97 g.L-1 in oolong tea and 6.75 g.L-1 in yerba mate tea. Acetic acid was the highest organic acid identified and quantified at the end of fermentation time. Flavonoids decreased during fermentation in both samples, while reducing capacity did not differ throughout fermentation time. Regarding the antioxidant capacity, in the formulations with oolong and yerba mate, it presented higher inhibitory capacity of the ABTS radical of 90.22 and 68.75%, while the DPPH radical inibitory capacity was 89.74% in oolong and 86.72% in yerba mate. Kombucha formulated with yerba mate tea resulted in a sour and refreshing beverage, with higher global acceptance compared to oolong tea, both drinks exhibiting antioxidant potential in vitro.
Estrus induction in the non-breeding season is not associated with hydrometra in dairy goats
Authors: Maia Ana Lucia Rosa e Silva , Souza-Fabjan Joanna Maria Gonçalves , Rangel Paulo Sergio Cerqueira , Côrtes Luana Rangel , Oliveira Maria Emilia Franco , Fonseca Jeferson Ferreira da
Published: August 2021

This study aimed to compare the prevalence of hydrometra (HD) at the end of the reproductive season in goats subjected (HORM and LIGHT) or not (Control-HORM and Control-LIGHT) to estrus induction by either hormonal protocol or light program, respectively, in the non-breeding season. HORM-goats received intravaginal sponges (six days) associated with cloprostenol plus eCG 24 h before sponge removal while LIGHT-goats were submitted to 16 h of light and 8 h of darkness for 60 days. Pregnant goats from both groups gave birth at the early reproductive season and were evaluated by transrectal ultrasound ~45 days after the end of the season. The control goats (Control-HORM and Control-LIGHT) were also examined. There was no difference in the prevalence of HD between goats from HORM (8/31; 25.8%) compared to Control-HORM (4/26; 15.4%), or LIGHT (9/54; 16.7%) compared to Control-LIGHT (7/51; 13.7%), as well as between HORM and LIGHT groups. In conclusion, estrus induction with both hormonal and light protocols is not associated with the development of HD in dairy goats.
Indústria 4.0 e Sociedade 5.0: visões comparadas
Authors: Glória Júnior Irapuan , Reis João Gilberto Mendes dos
Published: August 2021

As organizações têm sido apresentadas a uma nova forma de organização produtiva, a chamada de Indústria 4.0, com a promessa de integralização de seus processos, alta customização, alta produção e redução dos custos de produção. Baseado nos conceitos da Industria 4.0 surgiram diversas variações como a Logística 4.0, Saúde 4.0, e Agricultura 4.0. Porém, foi no Japão que surgiu a ideia Sociedade 5.0 que promete a aplicação de todos os aspectos da quarta revolução e seus desdobramentos em uma sociedade totalmente autônoma. O presente trabalho compara a Indústria 4.0 e a Sociedade 5.0 em relação a origem, elementos estruturantes e uso da tecnologia. A metodologia empregada foi uma pesquisa bibliográfica. O resultado apresenta uma lista de 10 características que comparam ano de criação do conceito, país de origem, necessidade motivadora, nível de urgência, foco, escopo de aplicação, emprego de tecnologia, grau de uso da inteligência artificial, elementos fundamentais e desdobramentos provenientes do conceito. As contribuições para a prática são do estabelecimento das diferenciações que podem contribuir para que estrategistas, investidores e gestores de produção possam compreender as diferenças e vislumbrarem um futuro próximo.
O uso de óleos essenciais associado à fisioterapia para o alívio da dor na dismenorreia: uma revisão sistemática
Authors: Aragão Mona Indianara da Costa , Correia Sabrina Amorim , Gomes Sylvia Christina Leite , Pereira Amanda Silva , Azevedo Kryzia de Moraes , Lima Williams Silva , Dias Sávia Francisca Lopes
Published: August 2021

Esta revisão tem como objetivo reunir evidências para identificar os possíveis benefícios do uso de OEs associado à fisioterapia para o alívio da dor na dismenorreia. Para a definição da questão de pesquisa de forma estruturada foi utilizado o formato do acrônimo PICO e o processo de busca de publicações apropriadas foi totalmente documentado pelos itens de Relatórios Preferenciais para Revisões Sistemáticas e Meta-Análise (PRISMA). Os artigos selecionados estudaram a utilização de variados OEs, sejam sozinhos ou em associação. Além da massagem como principal técnica, também foi encontrada a utilização de compressas quentes associadas a OEs para o alívio da dor. De maneira geral, os manuscritos revisados encontraram resultados positivos, mostraram que os OEs apresentam grandes benefícios no tratamento da DP. O uso dos OEs associado à fisioterapia, potencializa o tratamento e ameniza o quadro álgico nas mulheres acometidas por DP. Por outro lado, nenhum dos estudos mencionou ou apresentou dados a respeito da DS.
Caracterização epidemiológica da mortalidade por Alzheimer no Brasil entre 2010 a 2019
Authors: Matos Dalton Ferreira , Paz Wandklebson Silva da , Santos Allan Bruno Alves de Sousa , Silva Mikaelle Alves , Oliveira Samuel Felício de , Leite Carla Conrado Barbosa , Silva Millena Carla Rosa , Tavares André Cardoso , Oliveira Debora Kallyne Da Silva , Teles Mayara Martins , Silva Geovanna Magalhaes da , Balbino Rafael dos Santos , Pinto Mariana Marques , Melo Robert Lincoln Barros , Silva Andressa Cabral , Adão Marcos Benedito , Santos Maria Gisely Martins dos , Santos Joyce Francielle Ferreira , Almeida Delma Holanda de
Published: August 2021

O Alzheimer é uma doença do cérebro que está relacionada à idade do paciente, na qual a compreensão de sua progressão pode ser favorável para prevenir a doença através de uma intervenção precoce. As diferentes taxas de mortalidade nas grandes regiões do país apresentam desigualdades no desenvolvimento socioeconômico, necessitando de políticas públicas mais eficientes. Com isso está pesquisa é um estudo descritivo transversal epidemiológico, com o intuito de verificar a mortalidade por Doença de Alzheimer no Brasil durante os anos de 2010 a 2019, empregando dados de base populacional, de acordo a Secretaria de Vigilância em Saúde do Ministério da Saúde (SVS/MS) a partir dos bancos de dados do Sistema de Informação de Agravos de Notificação (SINAN). Onde no Brasil as características sociodemográficas predominantes foram: sexo feminino (64,54%), faixa etária ≥ 80 (74,99%); pessoas brancas (73,80%) e pessoas viúvas (50,66%), no entanto, alguns dados foram ignorados (9,42%) em que não se sabe o gênero, a faixa etária, a raça e o estado civil de alguns pacientes. Dessa forma, esse trabalho enfatiza a necessidade de investimentos em saúde pública, pois só assim os pacientes que possuem a doença de Alzheimer poderão ter atenção ao atendimento e adesão ao tratamento referente a essa doença.
Sobrevida de pacientes com doença falciforme diagnosticados durante a triagem neonatal: revisão sistemática
Authors: Pompeo Carolina Mariano , Ferreira Júnior Marcos Antonio , Cardoso Andreia Insabralde de Queiroz , Souza Mercy da Costa , Mota Felipe Machado , Ivo Maria Lúcia
Published: August 2021

Objetivo: Analisar os dados relativos à sobrevida de pacientes com doença falciforme diagnosticados durante o processo de triagem neonatal. Método: Revisão sistemática, realizada nas bases eletrônicas Current Index to Nursing and Allied Health Literature, Cochrane Library, National Library of Medicine, Scopus e Web of Science com descritores controlados indexados no Medical Subject Headings. Sem delimitação temporal ou de idioma. Resultados: Sete artigos compuseram a amostra final, todos publicados em inglês e de delineamento de coorte. A avaliação de risco de vieses pelo Newcastle Otawa Scale indicou que seis artigos foram considerados de alta qualidade. Foram estudadas as taxas de sobrevida global, estratificadas por genótipos, eventos clínicos agudos, sexo e níveis de hemoglobina, além da sobrevida livre de eventos. A sobrevida global apresentou variação entre 100% aos seis meses e 85,6% aos 18 anos, enquanto para o genótipo Sβº foi estimada em 55,2% aos 40 anos. Conclusão: Houve diminuição da sobrevida após os 30 anos de idade, entretanto, com aumento anual entre os períodos estudados. A elaboração de políticas públicas com inserção da comunidade no contexto de suas ações pode auxiliar na manutenção das estratégias de melhoria da sobrevida desta população.
Avanços no tema genes da prolificidade ou fertilidade em ovinos: revisão
Authors: Maciel Marilene dos Santos , Ribeiro Apolônio Gomes , Calvacante Paulo Otávio Silva , Carvalho Chrislanne Barreira de Macêdo , Marinho Jéssica Berly Moreira , Macambira Gabriel Miranda , Oliveira Helia Sharlane de Holanda , Silva Dayane Albuquerque da , Santos Ana Carolina Ferreira dos , Pessoa Diana Valadares , Silva Gabriela Duarte , Carvalho Yanne Cibelle Vieira de
Published: August 2021

As características de reprodução relativamente têm baixa ou média herdabilidade e não exibem uma resposta notável à seleção fenotípica. Portanto, a inclusão de informações genéticas dos genes associados à capacidade reprodutiva pode melhorar eficientemente a resposta de seleção. Os principais genes importantes que afetam a prolificidade e suas diversidades genéticas em diferentes raças de ovelhas vem sendo estudados em uma escala global. Onde, diferentes mutações associadas as características reprodutivas, incluindo taxa de ovulação e tamanho da ninhada, foram encontradas em várias raças de ovelhas em todo o mundo. Uma visão geral dos estudos sobre os principais genes da prolificidade mostrou que alguns alelos podem expressar diferentes efeitos fenotípicos em diferentes raças e, portanto, estudos adicionais sobre efeitos de interação são necessários para uma maior compreensão do controle genético da reprodução em ovinos. Com relação a metodologia de avaliação para as características de prolificidade, a aplicação de novas tecnologias torna-se necessário para encontrar novas variantes, que é essencial para estudos futuros. A metodologia adotada foi um estudo descritivo, resultando em uma revisão bibliográfica embasada em artigos científicos mundiais.
Peer-mentoring na educação em saúde: quais as suas aplicações, limitações e estratégias para o sucesso?
Authors: Silva Natanias Macson da , Freire Leonel Francisco de Oliveira , Aires Anne Itamara Benigna Evangelista , Silva Marcos Daniel Oliveira e , Souza Stheshy Vieira e , Andrade Micássio Fernandes de , Nascimento Ellany Gurgel Cosme do , Fernandes Thales Allyrio Araújo de Medeiros
Published: August 2021

Este estudo buscou investigar a contribuição do Peer-Mentoring na formação acadêmica de base e educação continuada de profissionais da saúde, bem como identificar as principais limitações, desafios e alternativas para atingir o sucesso de sua implementação. Trata-se de um estudo de revisão integrativa com busca sistemática, realizada nas bases de dados PubMed, Scopus, Web Of Science, Education Resources Information Center (ERIC) e Biblioteca Virtual em Saúde (BVS). Foram incluídos artigos eletrônicos, disponíveis na íntegra, nos idiomas português, inglês e/ou espanhol e publicados nos últimos 5 anos. Excluiu-se os estudos do tipo revisão de literatura, resumos, carta ao editor, manuscritos duplicados e estudos que não apresentaram relação com a temática. Os seguintes descritores foram combinados com os operadores booleanos AND e OR: “Peer-Mentoring”, “Peer Group”, “Mentoring”, “Mentors”, “Health Education” e "Education, Medical”. Foram coletados 31 artigos elegíveis, que passaram por uma análise na íntegra e fichamento dos dados. Os estudos foram agrupados em cinco categorias de análise: (1) contribuição do Peer-Mentoring no processo de formação acadêmica; (2) impacto do Peer-Mentoring na educação continuada de profissionais da saúde educação continuada; (3) limitações são encontradas durante a execução do Peer-Mentoring; (4) desafios pedagógicos que devem ser vencidos, no transcurso da mentoria entre pares; (5) Como atingir o sucesso durante a implantação e execução de programas de Peer-Mentoring?. O Peer-Mentoring mostrou-se capaz de melhorar significativamente o processo de ensino em saúde. Perspectivas futuras apontam para uma maior adesão, por parte das instituições de ensino, em inserir a mentoria entre pares nos programas pedagógicos.
Antimicrobial potential of a bioactive coating based on chitosan incorporated with clove essential oil in hamburger-like meat product
Authors: Alves Pâmela Inchauspe Corrêa , Radünz Marjana , Borges Caroline Dellinghausen , Bastos Caroline Peixoto , Timm Cláudio Dias , Gandra Eliezer Avila
Published: August 2021

The food industry is looking for strategies to prevent microbial growth in order to ensure food safety and shelf life. However, the use of synthetic preservatives, such as nitrate and nitrite in meat products, entails risks to human health. An alternative is the utilization of essential oils, widely known for their antimicrobial properties. This work aimed the antimicrobial potential of a bioactive coating based on chitosan incorporated with clove essential oil in in hamburger-like meat product. Through the analysis of antimicrobial activity by diffusion in agar and broth, there was an action against Gram-positive and Gram-negative bacteria. Regarding Staphylococcus aureus and Escherichia coli, the minimum inhibitory concentration (MIC) was 3.74 mg/mL and the minimum bactericidal concentration (MBC) was 374.33 mg/mL for both. In the micro atmospheric diffusion test, CEO reduced by up to 70 and 76% of the E. coli and S. aureus bacteria development, respectively. CEO was applied as an active component in chitosan-based coatings in hamburger-like meat, in which it was able to promote the control of microbial proliferation of Total Coliforms, Coliforms at 45 ⁰C and Coagulase-Positive Staphylococcus throughout 7 days of storage under refrigeration. It is concluded that the bioactive coating based on chitosan incorporated with clove essential oil promotes microbiological control in hamburger-like meat product.