bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors influencing readiness and perceptions of Interprofessional Education (IPE) implementation at the Faculty of Medicine, Udayana University
Authors: Darmayani I Gusti Ayu Sri , Manuaba Ida Bagus Amertha Putra , Yani Made Violin Weda , Sadeva I Gede Krisna Arim , Wulandari Putri Ayu , Erawati Ni Kadek Yudit , Tyas Ni Luh Putu Larasati Prabawaning , Supadmanaba I Gede Putu
Published: January 2025

Background: Currently, there is a learning method that includes two or more professions known as Interprofessional Education (IPE), which aims to create cross-disciplinary collaboration regarding principles and improve the quality of health services. However, implementing IPE in medical faculties has several obstacles influenced by various factors. Unfortunately, research related to the implementation of IPE is still minimal.
Objective: To evaluate the factors influencing the readiness and perception of implementing IPE at the Faculty of Medicine, Udayana University.
Methods: This research was carried out at the Faculty of Medicine, Udayana University, from May to October 2023, with first and second-year medical students as subjects. The number of samples is determined by total sampling. Data were analyzed using SPSS version 25.0 software. Univariate analysis consists of a description of the basic characteristics of the subject. The bivariate analysis took the form of a Chi-square comparative test. Statistical values are considered significant if p<0.05.
Results: A total of 379 students, most of whom were 19 years old and female, were obtained as samples. Most of the sample, 265 students (69.9%) and 288 students (76%), had a moderate level of perception and readiness, respectively. Based on bivariate analysis, the level of readiness was not influenced by gender (p=0.216), study program (p=0.069), class (p=0.293), and latest GPA (p=0.798). On the other hand, only the class factor was significantly related to the level of perception (p=0.027).
Conclusion: Force factors are significantly related to the level of readiness for implementing Interprofessional Education (IPE) at the Faculty of Medicine, Udayana University.
Effect of aerobic walking exercise on quality of life in office workers with mechanical chronic low back pain
Authors: Hardiyanto Muhammad Devy , Andriati Andriati , Wardani Nurul Kusuma , Tinduh Damayanti , Melaniani Soenarnatalina
Published: January 2025

Background: Low back pain (LBP) is a musculoskeletal disorder that can reduce quality of life. It commonly occurs in office workers, mainly due to sedentary lifestyles during the COVID-19 pandemic. Aerobic Walking Exercise is expected to be one of the solutions to improve the quality of life in patients with mechanical chronic low back pain with its easy implementation and patient compliance.
Methods: The subjects were 32 office workers equally divided into control and treatment groups. Both groups received conventional low back pain exercises. The treatment group received additional walking aerobic exercise for thirty minutes three times a week for eight weeks. Quality of life was assessed with SF-36, which was taken before and after eight weeks of intervention. Exercise supervision is carried out with the telerehabilitation method.
Results: The results showed significant improvement in all SF-36 domains in both groups (p < 0.05). Comparison of the value of changes in quality of life between groups after treatment showed that there was a significant increase only in the domain of physical function (p = 0.03), an insignificant increase in the domains of physical limitations, pain, vitality, social function, and mental health. In contrast, the domains of general health and emotional limitations were found to decrease. No side effects were found during the treatment.
Conclusion: The addition of walking aerobic exercise for eight weeks can improve the domain of physical function of SF-36 compared to conventional exercise alone.
Unrevealing the role of lacritin in eye disease: An updated systematic review
Authors: Eka Hasnah , Ichsan Andi Muhammad , Massi Muh. Nasrum , Muhiddin Habibah Setyawati , SU Suhardjo , Umar Batari Todja , Miskad Upik , Zairuddin Andi Alfian
Published: January 2025

Link of Video Abstract: https://youtu.be/L9MLcss_SBI
 
Introduction: Lacritin is a potential human tear glycoprotein for treating some diseases involving eye such as bacterial corneal ulcers. However, the specific role of lacritin in improving the condition of eye diseases is still not known with certainty. The purpose of this study is to review the role of lacritin in eye diseases.
Methods: This study used literature from January 2001 until June 2023 according to the (Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA). The literature was from electronic databases; PubMed, PubMed, WileyOnline, Science Direct, and Google Scholar. Full-text articles that evaluate the lacritin effect on bacterial corneal ulcers were included in this systematic review.
Results: A total of 26 studies were included in this review. Lacritin has a potential role in ZO1 expression (ZO1 is a type of protein structure in tight junction), which is essential for the corneal epithelium's structural integrity. Lacritin also induces tear protein secretion, which is an essential step in corneal ulcer healing.
Conclusion: Lacritin is potentially important in alternative modalities for bacterial corneal ulcers. However, a further study investigating the lacritin effect in corneal healing is suggested.
Epidermal growth factor receptor immunoreactivity in cervical squamous cell carcinoma and adenocarcinoma and its correlation with tumor characteristic
Authors: Dewi I Gusti Ayu Sri Mahendra , Sriwidyani Ni Putu , Ekawati Ni Putu Ekawati
Published: January 2025

Link of Video Abstract: https://youtu.be/41nNqfCOjaE
 
Background: Cervical cancer is the second most common cancer in women and occupies 15% of all cancers in women. The most common types of cervical cancer are squamous cell carcinoma and adenocarcinoma. Epidermal Growth Factor Receptor (EGFR) plays a role in cell differentiation, motility, invasion, and metastasis. Therefore, this study aims to prove the difference in EGFR immunoreactivity in squamous cell carcinoma and adenocarcinoma of the uterine cervix and to prove the association between EGFR immunoreactivity and the degree of tumor differentiation.
Methods: This is a cross-sectional analytical observational study, using biopsy or surgery specimens from patients with squamous cell carcinoma and cervical adenocarcinoma, whose tissues were examined at the Anatomical Pathology Laboratory Universitas Udayana/ Prof. IGNG Ngoerah Hospital Denpasar. Histopathological diagnosis, determination of the type of malignancy, and the degree of differentiation were performed with Hematoxylin and Eosin (H & E) staining. EGFR expression was evaluated by immunohistochemical staining, and data analysis was conducted using a chi-square test.
Results: There was a significant difference in EGFR expression between squamous cell carcinoma and adenocarcinoma (p = 0.026). Squamous cell carcinoma has a risk of prevalence of high EGFR expression of 2.5 times compared to adenocarcinoma. Low EGFR expression was found in 4 (80%) samples of low-grade squamous cell carcinoma, and high EGFR expression in 12 (80%) samples of high-grade squamous cell carcinoma. There was a significant difference in EGFR expression between low and high-grade squamous cell carcinoma (p = 0.015). There were low EGFR expression in 8 (100%) samples of low-grade adenocarcinoma and high EGFR expression in 5 (41.7%) samples of high-grade adenocarcinoma. There was no significant difference in EGFR expression between low and high-grade adenocarcinomas (p = 0.055).
Conclusion: There was a significant difference in EGFR expression between squamous cell carcinoma and adenocarcinoma.
Sensitivity and specificity of thyroid ultrasound for follicular thyroid carcinoma
Authors: Hidayat Muhammad Furqan , Susilo Dwi Hari , Wibowo Marjono Dwi , Wihandono Asdi
Published: January 2025

Link of Video Abstract: https://youtu.be/8J8wJ1fvuaY
 
Introduction: With the advancement of ultrasound examination technology in cases of thyroid nodule malignancy, several criteria and characteristic guidelines were developed, such as TIRADS (Thyroid Imaging, Reporting and Data System) criteria. These criteria assist clinicians in determining the diagnosis earlier than histopathological examination. The accuracy and sensitivity have been widely studied, but not much has been discussed regarding each characteristic item. This study aims to find the sensitivity, specificity, and accuracy of thyroid ultrasound examination against follicular-type thyroid carcinoma.
Method: This research is a retrospective cohort using medical record data of patients at Dr. Soetomo General Hospital Surabaya during the 5-year research period (2017-2021). The conclusion of USG results and characteristics of USG malignancy compared with histopathological results. The summary of USG results consists of TIRADS score, TIRADS score combined with nodule vascularization, TIRADS score combined with lymph node enlargement, and TIRADS score combined with lymph node location. USG characteristics consist of a solid nodule, microcalcification, irregular margin, nodule taller than wider, hypoechoic nodule, vascularization, enlargement of lymph node and location of lymph node
Result: The conclusion of USG results based on TIRADS, TIRADS combined with nodule vascularization, solid nodule characteristics, and lymph node enlargement characteristics have a strong relationship with malignant histopathology results (p-value <0.05), with the highest sensitivity in the conclusion of USG results, which is the TIRADS score combined with nodule vascularization (90.9%), the best specificity is almost the same in all scores, the best positive predictive value (PPV) (74.1%), negative predicted value (NPV) (80.0%) and accuracy (75,7%) is the TIRADS score combined with nodule vascularization. The characteristics of thyroid nodules are the characteristics that have the best sensitivity, namely 68.2%, specificity 68.7%, PPV 75%, NPV 58.8%, and accuracy level 67.5%
Conclusion: Ultrasonography (USG) results, solid nodule characteristics, enlarged lymph node characteristics and TIRADS score above 3 (3.5) can be used as predictors of malignancy in thyroid nodule cases earlier than histopathology results
Infiltration effect of ropivacaine on skin wound healing assessed by collagen density
Authors: Adjinegoro Lahuda , Sahudi  , Ghaib Husnul
Published: January 2025

Link of Video Abstract: https://youtu.be/juiwFS3TxfA
 
Introduction: The wound healing process is characterized by granulation tissue rich in new blood vessel networks and macrophages, granulocytes, endothelial cells, and collagen that fill the wound gap. Ropivacaine infiltration, which can be used as a long-acting local anesthetic, is expected to reduce surgical stress. One of the parameters that can be used to assess wound healing is collagen density. Thus, it needs to be determined whether there are differences in the administration of ropivacaine as a local anesthetic in supporting the improvement of wound healing influenced by collagen density
Methods: This study was an experimental study using a sample of 32 Wistar rats (Rattus norvegicus) which were randomly divided into 2 groups: the treatment group with 2 cm full-thickness wound incisions with 2,52 mg of ropivacaine infiltration, while the control group was given NaCl infiltration 0.9% 1 ml. Furthermore, wound tissue samples were taken on day 5 to calculate Collagen density through immunohistochemical examination.
Results: Anesthetic infiltration of post-surgical wounds can accelerate wound healing. There was a significant difference in collagen density between the control and treatment groups (p = 0.028) and a significant difference between the control and treatment groups (p = 0.011).
Conclusion: The infiltration of ropivacaine in wound healing increases the density of collagen and fibroblasts, triggering the formation of granulation tissue that supports the wound healing process.
The management of ovarian cancer in pregnancy: a rare case report
Authors: Praja Dewangga Wahyu , Primandono Perbowo
Published: January 2025

Link of Video Abstract: https://youtu.be/gGzNJpCiosc
 
Introduction: Ovarian tumors are found in approximately 1 in 1000 pregnancies. The simultaneous management of three separate yet interconnected entities: the mother, the fetus, and the disease complicates cancer care during pregnancy. The treatment of a pregnant woman with ovarian cancer is described in this paper.
Case Presentation: A 24-year-old pregnant lady (G2P0A1, 24 weeks gestational age, [GA]) was brought to our hospital after a routine prenatal ultrasound revealed a 15x18 cm left adnexal tumor. We discovered the complex adnexal mass, which was approximately 20x13.3x16 cm in size, in the left ovary, producing severe bilateral hydronephrosis on magnetic resonance imaging (MRI). The laboratory tests performed were within normal limits except for higher serum lactate dehydrogenase levels. At 34 weeks GA, the pregnancy was terminated via cesarean section. The baby (female, 1,600 g) was born alive with no congenital defects and an Apgar score of 3-5-7. Following that, a unilateral salpingo-oophorectomy was performed.  Pathology indicated a high-grade serous carcinoma of the left ovary with positive ascites fluid but no evidence of metastases to the pelvic lymph nodes, omentum, or peritoneum (stage IC). We had planned to treat the woman with a paclitaxel-carboplatin combination, but she declined because she preferred to breastfeed her infant. She had no abdominal issues at 15 months and was still breastfeeding the baby.
Conclusion: Pregnancy-related epithelial ovarian cancer is uncommon but is a possibility. Clinical findings, diagnostic, and treatment strategies are roughly similar to non-pregnant patients, except for the timing of chemotherapy initiation. Further research is needed to give evidence regarding these mother-infant dyads' survival and health outcomes.
Analysis of determinant factors of referral to maternal mortality in Indonesia: a retrospective cross-sectional study
Authors: Mahyul Indra , Muhammad Ardian Cahya Laksana  , Budi Prasetyo
Published: January 2025

Introduction: Maternal mortality is still quite high in Indonesia. It recorded 305 per 100,000 live births in 2015. An effective and efficient referral system can reduce maternal mortality by up to 80%. The problem in the referral system that is often faced is the limited accessibility to health services. This study analyzed the referral determinants factors that influence maternal mortality at Dr. Soetomo Hospital and Airlangga University Hospital for 2021-2022.
Methods: This is a retrospective cross-sectional study conducted at Dr. Soetomo Hospital and Airlangga University Hospital on 113 cases of maternal mortality that met the inclusion and exclusion criteria. The data was then processed and analyzed using the Structural Equation Modeling (SEM) test with JASP software.
Result: Patient as a factor significantly correlates to maternal mortality (p < 0.001). Patient factors contribute 70% to maternal mortality. Decision-making time, economic status, and travel time correlated with patient factors (p < 0.001) with contributions of 72.5%, 27.5%, and 38.1%. Patient factors and health system factors were able to explain 29.2% of maternal mortality, while other risk factors explained 70.8%.
Conclusion: Patient and health system factors contributed to maternal mortality at Dr. Soetomo General Hospital and Airlangga University Hospital.
Expression of Bax and Bcl-2 in mice lens epithelial cells to compare the anti-UV-B protection effect between anti-UV-B glasses and anti-UV-B contact lenses
Authors: Nurfahri Rifat , Nurwasis  , Indri Wahyuni
Published: January 2025

UV-B radiation has been widely proven to play a role in the occurrence of cataracts in addition to other degenerative processes. Protective equipment from UV-B radiation is thought to help prevent cataracts. However, there is no clear evidence that protective equipment such as anti-UV-B glasses and anti-UV-B contact lenses have the same protective effect. Meanwhile, UV-B radiation has been proven to increase apoptosis of lens capsule epithelial cells through the intrinsic apoptotic pathway involving Bax and Bcl-2. Bax as a pro-apoptotic factor and Bcl-2 as an anti-apoptotic factor will be affected by UV-B radiation and there will be a change in the Bax/Bcl-2 ratio which will cause damage to mitochondrial membrane permeability resulting in the release of cytochrome C which interacts with APAF-1 to form the apoptosome and activates caspase-9 which leads to apoptosis. Damage to mitochondrial membrane permeability is the point of no return in the apoptosis process and must occur in the intrinsic apoptosis pathway. Therefore, measuring Bax and Bcl-2 expression levels is expected to measure quantitatively the protective effect of anti-UV-B glasses and anti-UV-B contact lenses at the molecular level.
Assessment of factors associated with NLR, PWR, PLR, and LMR values in COVID-19 patients
Authors: Wikanningtyas Tri Ariguntar , Fachri Muhammad , Shabariah Rahmini , Resdyanugraha Diaz
Published: January 2025

Link of Video Abstract: https://youtu.be/t7r9Nvg_-q0
 
Background: Coronavirus Disease 19 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Parameters that support the diagnosis and assess the immune status and inflammation process crucial for the prognosis of COVID-19 patients include Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), Platelet to White Blood Cell Ratio (PWR), and Lymphocyte Monocyte Ratio (LMR). Age and comorbidities can also influence these values. This study assesses factors associated with NLR, PWR, PLR, and LMR values.
Methods: A cross-sectional study using the medical records of confirmed COVID-19 patients in Rumah Sakit Islam Jakarta Cempaka Putih and Sukapura from July to December 2020, with a total sample of 229 taken through a total sampling technique. For each patient, patient characteristics, including age, gender, comorbidity history, hospitalization, in-hospital death, NLR, PWR, PLR, and LMR values, were collected. Then, the relationship between these patient characteristics and NLR, PWR, PLR, and LMR values was analyzed using the chi-square test with SPSS version 22.0 for Windows.
Results: Patients aged 60 and above (84.7%) with a median age of 48 years, comorbidities (54.7%), in hospitalized non-ICU (92.3%), and mostly survivors (94.9%). Age is associated with NLR, PWR, PLR, and LMR values; gender is associated with LMR values, and comorbidity and hospitalization are associated with NLR, PLR, and LMR values. In-hospital death is not associated with these four values.
Conclusion: Age is associated with NLR, PWR, PLR, and LMR values, underscoring the importance of considering age as a critical factor in patient risk assessment and care. Medical teams should consider age-related differences in patient management and monitoring, especially for older patients.
Cuprum insertion in Cavernous Hemangioma: a case report
Authors: Purnama I Made Candra , Susilo Dwi Hari
Published: January 2025

Link of Video Abstract: https://youtu.be/LCgbzk6OYuo
 
Background: Hemangioma is the most common benign vascular tumor in infants and young children. Early treatment of hemangioma may potentially prevent complications. Various treatment approaches for hemangiomas have been reported and widely used, including a wait-and-see policy, laser treatment, drug treatment, sclerotherapy, radiotherapy, and surgery. However, no treatment can be used for all hemangiomas. The use of copper wire might be used as an alternative therapy for cavernous hemangioma.
Case Presentation: A 21-year-old male complained of a reddish, rubbery, and pulsating lump on the left cheek and neck. Physical examination and radiologic examination were performed to diagnose the patient. A suspicion of vascular lesions was made. A copper wire insertion approach was used for therapy management.
Conclusion: The use of percutaneous copper needles to induce therapeutic coagulation is an effective option for cavernous hemangioma treatment
Analysis of sociodemographic factors associated with adverse drug-drug interaction in patients with stable angina pectoris prescribed polypharmacy at outpatient cardiology clinic Ulin Public Hospital Banjarmasin
Authors: Akhlis Fuad Fajar , Bakhriansyah Mohammad , Yustikasari Intan , Nurikhwan Pandji Winata , Adiputro Dwi Laksono
Published: January 2025

Link of Video Abstract: https://youtu.be/K2LLRuJLoco
 
Background: Drug interactions can lead to either adverse or beneficial effects due to concomitant administration of drugs. The prevalence of drug interactions in patients with cardiovascular diseases has been reported to be high by 83-91%, especially in stable angina pectoris (SAP) patients. Various sociodemographic factors, including age, sex, education level, occupation, marriage status, and hypertension status, have been identified to influence drug interactions. This study aims to determine sociodemographic factors (age, sex, educational background, occupational status, marital status, and history of hypertension) that influence adverse drug-drug interactions in patients with SAP by using medical records.
Methods: It was a retrospective observational study with a cross-sectional approach conducted at the Outpatient Cardiology Clinic, Ulin Public Hospital Banjarmasin, Indonesia, from 2020 to 2021. The drug-drug interactions were determined by using the Lexicomp tool from the UpToDate® website. Prevalence odds ratios (PORs) and 95% confidence intervals (95%CI) were calculated using a logistic regression test.
Results: We identified 84 SAP patients prescribed 335 drug-drug interactions. Most patients were prescribed major polypharmacy (44 patients, 52.38%), and most interactions were under category C, i.e., close monitoring of therapy (220 interactions, 65.67%). Our study demonstrated that a year increase in age was associated with a significantly increased event of adverse drug-drug interaction by 1.106 times (adjusted POR 1.106, 95%CI 1.003-1.220, p=0.043).
Conclusion: In conclusion, among any other sociodemographic factors, only age was significantly associated with an increased event of adverse drug-drug interactions among SAP patients with polypharmacy at Ulin Public Hospital Banjarmasin, Indonesia.
Mortality prevalency of trauma patients with COVID-19 infection who underwent tracheostomy at dr. Soetomo General Hospital in 2022 – 2023
Authors: Adjinegoro Lahuda , Wibowo Maryono Dwi
Published: January 2025

Link of Video Abstract: https://youtu.be/DzBbHSVJGxI
 
Introduction: A tracheostomy procedure may be necessary to speed up the weaning process because of the high prevalence of endotracheal extubation and ventilator weaning failure during the COVID-19 pandemic. In trauma patients, severe respiratory failure, upper airway blockage, inability to wean off mechanical ventilation, and copious secretions are common reasons for tracheostomy procedures. This study aims to examine the prevalence of mortality of trauma patients with COVID-19 who are undergoing tracheostomy to see if tracheostomy can help the therapy of trauma cases, especially for weaning from mechanical ventilation and airway complications.
Methods: This research is a descriptive observational study. We used the cross-sectional method to collect data. Information was extracted from the medical records of COVID-19 trauma patients who had tracheostomies at Dr. Soetomo General Hospital, Surabaya, between January 2022 and December 2023. A descriptive data analysis was conducted to determine each research variable's frequency and proportion. Version 26 of the IBM Statistics Desktop Software (SPSS) was used for this investigation.
Results: 50 trauma patients underwent tracheostomy at Dr. Soetomo General Hospital, consisting of 33 male and 17 female patients. Of these 50 patients, 12 had positive covid-19 and 38 had negative covid-19. Of the total 50 patients who underwent tracheostomy, 30 patients died, while 20 patients lived.
Conclusion: The prevalence of mortality in COVID-19 patients with tracheostomy treated at RSUD Dr. Soetomo Surabaya from 2022 to 2023 was 60%. Of the 50 patients, 28% of patients with positive covid-19 status were obtained, and 72% of patients had negative covid-19 status.
Exploring the complex interplay of herpes simplex virus and HIV/AIDS - a comprehensive narrative review
Authors: Yunita Ira , Hidayati Afif Nurul , Widyantari Septiana , Astindari  , Sari Maylita , Agusni Regitta Indira , Indrawati Ditya , Huda Berliana Kurniawati Nur , Murtiastutik Dwi
Published: January 2025

Herpes simplex virus (HSV) infections are highly prevalent globally and are attributed to two distinct kinds of HSV. The primary clinical presentations are mucocutaneous infections, with HSV type 1 (HSV-1) predominantly linked to orofacial ailments, and HSV type 2 (HSV-2) typically connected with genital infections. Herpes simplex is a highly prevalent disease due to its persistent nature, frequent recurrences, and the potential for transmission from individuals who may not exhibit symptoms or be asymptomatic. The reactivation of HSV can result in substantial elevations in morbidity and mortality rates among patients with impaired immune systems, especially those affected by human immunodeficiency virus (HIV). HSV is classified into two distinct kinds, namely HSV-1 and HSV-2. HSV-1 is mostly linked to orofacial pathology, whereas HSV-2 typically induces genital infection. However, it is important to note that both types of herpes simplex virus have the ability to infect both oral and genital regions, leading to the development of acute and recurring infections. Recurrent infections of HSV are prevalent among individuals with HIV infection. These episodes can be more severe and longer, resulting in significant morbidity and mortality. The severity of these recurrent infections is associated with low CD4 cell counts, whereas higher CD4 cell counts are associated with a reduced likelihood of recurrence. The aim of this review is to thoroughly study the Herpes Simplex virus (HSV), understand the differences between the types of HSV, find out why this virus still exists, and discuss its impact on health.
Prognostic factors of peritoneal dialysis-related to peritonitis at Hasan Sadikin General Hospital, Bandung, Indonesia
Authors: Kurniawan Aninditho Dimas , Tjahjodjati
Published: January 2025

Link of Video Abstract: https://youtu.be/qhS-THemVqM
 
Background: Peritoneal dialysis (PD)-associated peritonitis is the most concerning PD-related infection as it carries significant morbidity, mortality, and added treatment costs and is a leading cause of PD technique failure. Many factors are linked to an increase in the risk of mortality peritonitis-related CAPD, but the data were inconsistently reported. Our study was conducted to determine the association between the onset of peritonitis and prognostic factors related to CAPD patients.
Methods: This was a retrospective observational cohort study. Nineteen peritonitis-related CAPD patients (8.40%) were screened from 226 patients who underwent CAPD insertion at Hasan Sadikin General Hospital, Bandung West Java, between January 2016 and December 2021. Patients included in this study were 18 or older, and those with incomplete medical records were excluded. Statistical methods used Fisher exact and Kolmogorov-Smirnov for categorical data. Chi-square tests were used to test relative risk and prognostic factors.
Results: A total of 19 patients (early onset of peritonitis, n = 16; late onset of peritonitis, n = 3) were analyzed in our study, with most of the subjects between 35-50 years old, consisting of males 63.2% and 12 patients (63.2%) with CAPD insertion by open technique. Patients who were underweight or overweight had an increased risk of peritonitis (RR 1.288 and 0.833, respectively, p=0.047). There was a significant association between diabetes melitus with increased risk of peritonitis (RR 1.157 p=0.041).
Conclusion: This study showed that early-onset peritonitis patients are related to poorer prognosis compared to late-onset peritonitis. Diabetes Mellitus and underweight or overweight were significantly increasing poor prognostic factors of peritonitis-related CAPD patients.
Alpha-blocker administration after Transurethral Resection of Prostate (TURP) procedure
Authors: Ardiansyah Novan , Abriansyah Aryo Teguh , Santoso Jumadi
Published: January 2025

Link of Video Abstract: https://youtu.be/bcavIohiMKI
 
Background: Benign prostatic hyperplasia (BPH) is one of the most prevalent urological conditions that affect aging men. Alpha-1 adrenergic receptor inhibition medications such as Tamsulosin treat the dynamic component of benign prostatic hyperplasia. Transurethral Resection of the Prostate (TURP) is a procedure for patients who meet relative or absolute indications for surgery. This study aims to investigate whether the administration of Alpha blocker prevents acute urinary retention in patients post-TURP.
Methods: This is a randomized experimental study. The inclusion criteria include BPH patients and post-TURP procedures. A total of 60 Patients were divided into 2 groups: a tamsulosin group (30 patients) and a placebo group (30 patients). The urinary catheter was removed two days after the procedure. The patient followed up with an episode of urinary retention until seven days after the procedure. Data were analyzed using SPSS version 26.0 for Windows.
Results: There was 10% (3 of 30 patients) from the first group (Tamsulosin group) and 6.6% (2 of 30 patients) from the second group (placebo group) experienced urinary retention. Both patients from the second group experienced immediate acute urinary retention after the urinary catheter was removed. In the first group, the first patient experienced urinary retention on the fifth day, and the second and third patients experienced urinary retention on the seventh day.
Conclusion: Administration of Alpha-blocker (Tamsulosin 0.4mg) had no significant benefit in preventing acute urinary retention in patients post-TURP.
Costae rib resection and bypass right caroticosubclavian artery for thoracic outlet syndrome and follow up after 6 months: a rare case
Authors: Septiandi Yohannes , Winarno Dhihintia Jiwangga Suta , Rizki Mohamad
Published: January 2025

Link of Video abstract: https://youtu.be/6Ii8V3P1_Ys  
 
Introduction: The condition known as TOS is brought on by pressure on the nerve plexuses and blood vessels in the upper thoracic aperture region. Congenital or acquired abnormalities may be cause for this. The symptoms of TOS, which are caused by compression of the brachial plexus or subclavian artery or vein. Depending on the arteries, veins, nerves, or anatomical anomalies that are impacted, different symptoms may manifest. This study aims to increase our familiarity with the symptoms of TOS and follow-up postoperative outcomes after 6 months.
Case Presentation: A 32-year-old man was referred to a tertiary hospital in Surabaya from a secondary hospital in Surabaya. Patients complain of right arm pain about 1 month before. The CTA evaluation right subclavian artery stenosis, right radial artery stenosis, right posterior interosseus artery stenosis. The patient underwent elective surgery for costae rib resection and bypass right caroticosubclavian artery. Evaluation postoperative after surgery, the patient was treated in the low care room with early extubated conditions. Extubation is done immediately in OT. Three days after extubation the patient went home. 6 days postoperatively patient controls into the outpatient department of cardiothoracic surgery. Progress was followed up to 6 months and yielded a good result.
Conclusion: Surgical intervention is a possibility for treating the symptoms that patients describe suffering. Decompress the thoracic outlet by removing the first rib, either alone or in conjunction with additional vascular reconstructive surgeries.
Relationship of passive legs raising with inferior vena cava distensibility index in children with shock
Authors: Pribadi Muhammad Ibrahim , Martuti Sri , Siregar Rustam
Published: January 2025

Background: Shock is a clinical syndrome resulting from the body's circulatory system failure, which requires fluid administration and/or vasopressors. Passive leg raising (PLR) examination and inferior vena cava distensibility index (IVCDI) examination are necessary to determine the need for fluid resuscitation in children with shock. The relationship between PLR and IVCDI in children with shock is very important to research. This study aims to find out the relationship between PLR and IVCDI in children with shock.
Methods: This research was a quasi-experimental study and employed one group pre-test post-test design. The research subjects were children aged 5 - 18 years with a diagnosis of shock in the PICU of Dr. Moewardi Hospital from June 2022 to July 2022. Data were analyzed using SPSS version 25.0 for Windows.
Results: There were 12 children who experienced shock; 9 patients had a positive fluid responsiveness (FR), and 3 patients had a negative FR. In the positive FR group, there was a significant decrease in IVCDI (-50.15 ± 37.34, p=0.008). In the negative FR group, there was an increase in IVCDI (2.50 ± 5.55, p = 0.517), although it was not significant.
Conclusion: There is a relationship between PLR and IVCDI in pediatric patients with shock
Combined ipsilesional excitation and contralesional inhibition of Repetitive Transcranial Magnetic Stimulation (rTMS) as a motor rehabilitation in ischemic stroke patient: a case report
Authors: Tammasse Jumraini , Gunawan Anthony
Published: January 2025

Link of Video Abstract: https://youtu.be/Unt1HueFSEE
 
Background: Stroke is one of the major health problems in the world, with high mortality and disability rates. Transcranial Magnetic Stimulation (TMS) is a non-invasive and safe method of stimulating neurons in the brain. Various studies have used rTMS as an adjunctive modality to enhance motor restoration after stroke.
Case Presentation: A 35-year-old man was brought to the hospital with sudden weakness in the right side of his body since 9 days ago. On neurological examination, there was paresis of right cranial nerves VII and XII and left internuclear ophthalmoplegia. His motor strength in the right extremities was 1 for the deltoid and iliopsoas and 0 for other muscles. He received combined ipsilesional excitation in C3, left dorsolateral prefrontal cortex (DLPFC), and contralesional inhibition in C4. His proximal motor strength and diplopia slightly improved after treatment.
Conclusion: Combined ipsilesional excitation in the ipsilesional motor cortex and DLPFC and inhibition in the contralesional motor cortex can improve motor strength and diplopia in ischemic stroke patients.
Comparison of the immunomodulatory potential of tuber extracts Purple Sweet Potato (Ipomoea batatas L) and Sembung leaf extract (Blumea balsamifera L) in an oxidative stress rat model induced by maximum physical activity
Authors: Yasa I Wayan Putu Sutirta , Subawa Anak Agung Ngurah , Jawi I Made
Published: January 2025

Link of Video Abstract: https://youtu.be/PAliBnEh_Ac
 
Background: Heavy physical activity causes changes in the distribution of leukocyte subpopulations due to oxidative stress. Research shows decreased CD4 due to heavy physical activity and increased pro-inflammatory interleukins. This study aimed to compare the benefits of exogenous antioxidants from two medicinal plant extracts, purple sweet potato tuber extract and sembung leaf extract, in the maximal swimming rat model.
Methods: The research subjects were 27 adult Wistar rats divided into 3 groups using a randomized posttest-only control group design. The mice were divided into 3 groups, namely the control group (9 animals), which was not given purple sweet potato tuber extract or sembung leaf extract. Treatment group 1 (9 animals) was given 200 mg/day of purple sweet potato tuber extract for 2 weeks. Treatment group 2 (9 animals) was given sembung leaf extract at 4 mg/day for 2 weeks. After 2 weeks of administering the extract, all mice swam for 30 minutes (until they nearly drowned). After swimming, blood was examined for TNF-α, CD4, hematopoietic stem cells, and MDA. The data obtained was analyzed using the ANOVA test to see differences between groups.
Results: The results showed that CD4 cells for the group given sembung leaf extract were higher but not significant (p>0.05). HSC (Hematopoietic Stem Cell) cells were higher than the control group (p<0.05) in both treatment groups. MDA and TNFα levels were highest in the control group compared to the treatment group (p<0.05) and did not differ between the two treatment groups (p>0.05).
Conclusion: The conclusion of the research was that giving purple sweet potato tuber extract and sembung leaf extract both caused higher HSC and lower MDA and TNFα, so both test ingredients were immunostimulators, antioxidants, and anti-inflammatory.
Evaluation of the accordance of dermoscopy and histopathological examination results in patients who were clinically diagnosed as basal cell carcinoma
Authors: Huda Berliana Kurniawati Nur , Listiawan Muhammad Yulianto , Murtiastutik Dwi , Utomo Budi , Kusumaputra Bagus Haryo , Sari Maylita , Citrashanty Irmadita
Published: January 2025

Introduction: The incidence of basal cell carcinoma (BCC) has increased in recent decades, especially in people of color. Early diagnosis is needed as a preventive measure. The use of dermoscopy increases the sensitivity of diagnosis when combined with clinical examination using the naked eye. Histopathological examination is used as the gold standard examination to confirm the diagnosis. This retrospective study was conducted to evaluate the suitability of the results of dermoscopic and histopathological examinations in patients clinically diagnosed as BCC, to increase knowledge, help to train approaches to BCC diagnosis and serve as a consideration in making decisions on histopathological examination and further management for patients with BCC.
Method: A cross-sectional retrospective study design with an analytic observational study. A total sampling technique was performed from the patient’s medical records with a diagnosis of BCC. Analysis of the concordance of the results of dermoscopic and histopathological examinations in patients clinically diagnosed as BCC was analyzed using Fisher's exact test.
Result: There were 29 subjects in total. Dermoscopically, 23 subjects and 6 subjects were diagnosed as BCC and non-BCC. Histopathologically, 20 subjects and 9 subjects were confirmed as BCC and non-BCC. The concordance of dermoscopy and histopathological diagnosis showed k = 0.56 with 95% sensitivity, 55.6% specificity, 82.76% accuracy, 2.14 positive likelihood ratio (LR+), and 0.09 negative likelihood ratio (LR-). Dermoscopic features with shiny white areas were the most dominant feature (RR= 8,167).
Conclusion: Dermoscopy and histopathology have a significant concordance in diagnosing BCC. Dermoscopy can sharpen clinical examination in diagnosing BCC. The appearance of shiny white structures can increase our awareness of the diagnosis of BCC through dermoscopy, especially in people of color.
Secretome derived from umbilical-cord mesenchymal stem cell enhances the effectiveness of autogenous bone graft in mandibula: a study in rabbit model
Authors: Arista Timotius Hansen , Saputro Iswinarno Doso , Hutagalung Magda Rosalina
Published: January 2025

Introduction: To the best of our knowledge, research has primarily focused on investigating secretome from bone marrow mesenchymal stem cells (BM-MSCs) for autogenous bone graft; umbilical-cord mesenchymal stem cell  (UC-MSCs) secretome remains unexplored. Herein, the aim of the study was to assess the effect of UC-MSCs secretome injection in autogenous bone grafts in rabbit models.
Methods: An experimental study using post-test-only control group design was conducted at Biochemistry Laboratory, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia from August 2023 to January 2024 on six male New Zealand rabbits (Oryctolagus cuniculus). Each rabbit underwent autogenous bone graft on the left and right mandibula. The right mandibula received UC-MSCs secretome injection, serving as an intervention group, while the left mandibula served as control group. UC-MSCs secretome was percutaneously injected into the intervention group every 3 days for 21 days. The following parameters were evaluated: number of osteoblast cells and collagen density.
Results: The intervention group exhibited a statistically significant difference in the number of osteoblast cells (p<0.001), with intervention group showing higher mean values (mean±SD=53.0±9.80) than control group (mean±SD=20.5±8.66). Similarly, for collagen density, a statistical difference was obtained in the intervention group (p=0.002), with the intervention group displaying higher mean values (mean=9.5) than control group (mean=3.5).
Conclusion: UC-MSCs secretome demonstrates significant osteogenic potential and safe application, making it a potential recommendation for bone defect repair. Percutaneous injections of UC-MSCs secretome into autogenous bone grafts every 3 days for 21 days enhance bone healing, indicated by higher osteoblast cell production and collagen density compared to standard of care.
Effects of transcutaneous auricular vagus nerve stimulation (TVNS) on heart rate variability (HRV) in chronic low back pain patients
Authors: Sau Pratiwi Tenri , Poerwandari Dewi , Prawitri Yudith Dian , Melaniani Soenarnatalina
Published: January 2025

Link of Video Abstract: https://youtu.be/CdSLXupKkQcBackground: Chronic low back pain (LBP) is the second cause of disability. LBP often causes recurrence, which causes disability, affecting productivity and daily activities and affecting quality of life. Transcutaneous auricular vagus nerve stimulation (tVNS) is a technique of electrical stimulation of vagus nerve afferents that is used as a therapy for chronic pain.
Methods: This research is an experimental study with a pretest-posttest randomized controlled group study with 22 subjects with chronic mechanical LBP aged 16-55 years who were randomly allocated into an exercise group (control group) and exercise with an additional tVNS group (treatment group). Heart Rate Variability (HRV) parameters assessed were Root Mean Square of Successive Differences Between Normal Heartbeats (RMSSD), Standard Deviation of Normal to Normal R-R intervals (SDNN), Low Frequency/ High Frequency (LF/HF) ratio before and after the intervention.
Results: There was a significant improvement in Heart Rate Variability for both groups before and after the intervention, but the treatment group was higher than the control group. Intervention group components RMSSD (p= 0.01), SDNN (p= 0.01), and LF/HF ratio (p= 0.00). In the control group, there were significant differences in RMSSD (p=0.02), SDNN (p=0.06), and LF/HF ratio (p=0.01). Comparison values of Δ RMSSD, Δ SDNN, and Δ LF/HF ratio between groups after 2 weeks of training did not show a significant improvement in RMSSD (p=0.53), SDNN (p=0.87), LF/HF ratio 0.98. The effect size values in the treatment and control groups were small for RMSSD and very small for SDNN and LF/HF ratio.
Conclusions: The addition of tVNS to exercise therapy on the HRV parameters of chronic LBP patients for 2 weeks shows better improvements compared to exercise therapy alone. Both tVNS addition to exercise therapy and exercise therapy alone can have a positive effect on improving HRV parameters, although there are no significant differences between the two groups.
Plantar pressure and level of risk stratification for foot ulcers in type II diabetes mellitus patients
Authors: Primalia Tirandan Menoer Elliza , Pawana I Putu Alit , Utami Ditaruni Asrina , Utomo Budi
Published: January 2025

Link of Video Abstract: https://youtu.be/Cb5Q1E2lIME
 
Background: One of the complications of diabetes mellitus is diabetic foot, both with and without ulcers. The International Working Group on the Diabetic Foot (IWGDF) in 2019 established risk stratification of foot ulcers for diabetes mellitus patients based on clinical appearance. Quantitative measurements, such as measuring plantar pressure distribution to assess ulcer risk, are also recommended. This study aims to prove the relationship between plantar pressure and the level of risk stratification of ulcers on the feet of patients with type 2 diabetes mellitus.
Methods: This study is an analytical observational study with a cross-sectional design. The subjects were 41 type 2 diabetes mellitus patients aged 18-59 years without active foot ulcers and a history of amputation. All subjects underwent an assessment of the level of ulcer risk stratification based on IWGDF criteria and received plantar pressure distribution measurements in one visit using an in-shoe measurement system (Pedar-X).
Results: The peak pressure, maximum force, and contact area values of the right and left foot did not have significant differences for each level of risk stratification, except for the peak pressure forefoot of the right foot (p = 0.01 and r = -0.39), maximum force all foot of the right foot (p = 0.03 and r = -0.34), and contact area toes of the right foot (p = 0.04 and r = -0.31), as well as the contact area of the toes and big toes of the left foot (p = 0.01 and r = -0. 39; p = 0.28 and r = -0.32). The level of foot ulcer risk stratification has a significant correlation with HbA1C (p=0.02).
Conclusions: There was no significant correlation of peak pressure, maximum force, and contact area values of the right and left feet, except for peak pressure of the forefoot of the right foot, maximum force of all feet of the right foot, contact area toes of the right foot, contact area toes and big toes of the left foot. A significant correlation was found between HbA1C and the level of foot ulcer risk stratification.
Chordoma in pregnancy: case report
Authors: Aspiannur Syaiful , Wicaksono Budi , Basuki Muhammad Hardian
Published: January 2025

Introduction: Chordoma represents an uncommon form of bone cancer frequently manifesting within the spinal column or cranium. Most often occurs at the top of the spine (basis cranial) or at the bottom of the spine (sacrum). The clinical manifestations of chordoma vary according to the location of the tumor because the lesion grows slowly and can be locally destructive. Typically, chordomas in the spinal column and sacrum manifest with pain and symptoms of nerve compression, including radiculitis, urinary and bowel incontinence, and sexual dysfunctions.
Case Report: A 44-year-old woman, elderly primigravida, was referred by a peripheral hospital with suspicion of a mass in the rectum. The patient was then referred to the Surgical Clinic of the Referral Hospital and a Pelvic MRI examination was planned. The patient was then consulted at the maternity clinic at the Tertiary Referral Hospital. Treatment was administered for the preterm rupture of membranes during the 30th/31st week of gestation in the patient. MRI showed a Primary bone tumor destroying Sacral Vertebrae 2,3,4,5 and Part of Sacral Vertebrae 1 with a size of 15.8 x 13.1 x 14.33 cm; Intrauterine Fetus. The patient was planned to be delivered by cesarean section and a core biopsy was performed by an orthopedic colleague. Core Biopsy results showed Chordoma. The patient was planned for surgery by Orthopedics.
Conclusion: Chordoma in pregnancy is rare, demanding meticulous management to minimize morbidity. Its obstruction of the birth canal necessitates planned cesarean sections for safe delivery. Pregnant women with Chordoma face challenges like urinary and bowel issues due to pressure from the enlarged uterus. Despite physiological changes during pregnancy, Chordoma exacerbates these problems. An emergency cesarean section was performed in one case due to premature membrane rupture, resulting in an initially unfavorable outcome. However, the baby's condition improved with three weeks of treatment, allowing outpatient care.