bluuebunny/crossref_metadata_2025 huggingface dataset:
Warming and temperature variability determine the performance of two invertebrate predators
Authors: Morón Lugo Sonia C. , Baumeister Moritz , Nour Ola Mohamed , Wolf Fabian , Stumpp Meike , Pansch Christian
Published: April 2020

In a warming ocean, temperature variability imposes intensified peak stress, but offers periods of stress release. While field observations on organismic responses to heatwaves are emerging, experimental evidence is rare and almost lacking for shorter-scale environmental variability. For two major invertebrate predators, we simulated sinusoidal temperature variability (±3 °C) around todays’ warm summer temperatures and around a future warming scenario (+4 °C) over two months, based on high-resolution 15-year temperature data that allowed implementation of realistic seasonal temperature shifts peaking midpoint. Warming decreased sea stars’ (Asterias rubens) energy uptake (Mytilus edulis consumption) and overall growth. Variability around the warming scenario imposed additional stress onto Asterias leading to an earlier collapse in feeding under sinusoidal fluctuations. High-peak temperatures prevented feeding, which was not compensated during phases of stress release (low-temperature peaks). In contrast, increased temperatures increased feeding on Mytilus but not growth rates of the recent invader Hemigrapsus takanoi, irrespective of the scale at which temperature variability was imposed. This study highlights species-specific impacts of warming and identifies temperature variability at the scale of days to weeks/months as important driver of thermal responses. When species’ thermal limits are exceeded, temperature variability represents an additional source of stress as seen from future warming scenarios.
Trichoderma virens Gl006 and Bacillus velezensis Bs006: a compatible interaction controlling Fusarium wilt of cape gooseberry
Authors: Izquierdo-García L. F. , González-Almario A. , Cotes A. M. , Moreno-Velandia C. A.
Published: April 2020

The combination of Trichoderma virens Gl006 and B. velezensis Bs006 as a consortium has high potential to control Fusarium wilt (FW) of cape gooseberry (Physalis peruviana) caused by Fusarium oxysporum f. sp. physali (Foph). However, the interactions between these two microorganisms that influence the biocontrol activity as a consortium have not been studied. Here, we studied the interactions between Gl006 and Bs006 that keep their compatibility under in vitro and greenhouse conditions. Antagonism tests between Gl006 and Bs006 inoculated both individually and in consortium against Foph strain Map5 was carried out on several solid media. The effect of supernatant of each selected microorganism on growth, conidia germination, biofilm formation and antagonistic activity on its partner was also studied. Biocontrol activity by different combinations of cells and supernatants from both microorganisms against Fusarium wilt was evaluated under greenhouse conditions. In vitro antagonism of the consortium against Foph showed a differential response among culture media and showed compatibility among BCA under nutritional conditions close to those of the rhizosphere. The supernatant of Bs006 did not affect the antagonistic activity of Gl006 and vice versa. However, the supernatant of Bs006 promoted the biocontrol activity of Gl006 in a synergistic way under greenhouse, reducing the disease severity by 71%. These results prove the compatibility between T. virens Gl006 and B. velezensis Bs006 as a potential tool to control Fusarium wilt of cape gooseberry.
Minimum fertilization at the appearance of the first flower benefits cotton nutrient utilization of nitrogen, phosphorus and potassium
Authors: Luo Honghai , Wang Qiang , Zhang Jiekun , Wang Leishan , Li Yabing , Yang Guozheng
Published: April 2020

There are currently many problems related to excessive fertilizer application, low fertilizer-use efficiency and lack of an agricultural labor force for cotton production in China. Therefore, the objective of this paper was to explain the optimal application time for once fertilization based on cotton nutrient accumulation of nitrogen, phosphorus and potassium to provide technical support for simplified fertilization management in cotton production. A 2 yr field experiment and a 1 yr pot experiment were conducted with fertilizer (225, 67.5, and 225 kg ha−1 of N, P2O5, and K2O, respectively) applied once at 0 (FT1), 5 (FT2), 10 (FT3), 15 (FT4), or 20 (FT5) d after the appearance of the first flower and a triple application (preplant 30%, first bloom 40%, and peak bloom 30%) as the conventional control (FT6). The results showed that FT1 exhibited the greatest nutrient accumulation speed for both the average (5.81, 1.22, and 5.74 kg ha−1 of N, P2O5, and K2O, respectively) and the maximum (6.31, 1.44, and 6.24 kg ha−1 of N, P2O5, and K2O, respectively) during the fast accumulation period. Moreover, among the different treatments, FT1 exhibited the greatest nutrient recovery and partial productivity. The results suggest that applying the minimum amount of fertilizer at the appearance of the first flower is optimal for maximizing nutrient utilization while minimizing environmental disturbance.
Selective multi-nanosoldering for fabrication of advanced solution-processed micro/nanoscale metal grid structures
Authors: Oh Y. S. , Lee J. , Choi D. Y. , Lee H. , Kang K. , Yoo S. , Park I. , Sung H. J.
Published: April 2020

Solution-processed metal grid transparent conductors with low sheet resistance, high optical transmittance and good mechanical flexibility have great potential for use in flexible optoelectronic devices. However, there are still remaining challenges to improve optoelectrical properties and electromechanical stability of the metallic structures due to random loose packings of nanoparticles and the existence of many pores. Here we introduce a selective multi-nanosoldering method to generate robust metallic layers on the thin metal grid structures (< a thickness of 200 nm), which are generated via self-pining assisted direct inking of silver ions. The selective multi-nanosoldering leads to lowering the sheet resistance of the metal grid transparent conductors, while keeping the optical transmittance constant. Also, it reinforces the electromechanical stability of flexible metal grid transparent conductors against a small bending radius or a repeated loading. Finally, organic light-emitting diodes based on the flexible metal grid transparent conductors are demonstrated. Our approach can open a new route to enhance the functionality of metallic structures fabricated using a variety of solution-processed metal patterning methods for next-generation optoelectronic and micro/nanoelectronic applications.
The Liver and Kidneys mediate clearance of cardiac troponin in the rat
Authors: Muslimovic Aida , Fridén Vincent , Tenstad Olav , Starnberg Karin , Nyström Susanne , Wesén Emelie , Esbjörner Elin K. , Granholm Kristoffer , Lindahl Bertil , Hammarsten Ola
Published: April 2020

Cardiac-specific troponins (cTn), troponin T (cTnT) and troponin I (cTnI) are diagnostic biomarkers when myocardial infarction is suspected. Despite its clinical importance it is still not known how cTn is cleared once it is released from damaged cardiac cells. The aim of this study was to examine the clearance of cTn in the rat. A cTn preparation from pig heart was labeled with fluorescent dye or fluorine 18 (18 F). The accumulation of the fluorescence signal using organ extracts, or the 18 F signal using positron emission tomography (PET) was examined after a tail vein injection. The endocytosis of fluorescently labeled cTn was studied using a mouse hepatoma cell line. Close to 99% of the cTnT and cTnI measured with clinical immunoassays were cleared from the circulation two hours after a tail vein injection. The fluorescence signal from the fluorescently labeled cTn preparation and the radioactivity from the 18F-labeled cTn preparation mainly accumulated in the liver and kidneys. The fluorescently labeled cTn preparation was efficiently endocytosed by mouse hepatoma cells. In conclusion, we find that the liver and the kidneys are responsible for the clearance of cTn from plasma in the rat.
Biopesticide synergy when combining plant flavonoids and entomopathogenic baculovirus
Authors: Hay William T. , Behle Robert W. , Berhow Mark A. , Miller Andie C. , Selling Gordon W.
Published: April 2020

Four crop plants known to be hosts for the lepidopteran Trichoplusia ni (soybean, green bean, cotton, and cabbage) were treated with the biopesticide AfMNPV baculovirus in a dosage response assay. Treated soybean had, on average, a 6-fold increase in virus activity compared with the other crops. Leaf trichomes on soybeans were not found to be responsible for the observed increase of insecticidal activity. Three flavonoid compounds (daidzein, genistein, and kaempferol) were uniquely found only in the soybean crop, and were not detected in cotton, cabbage, or green bean plant matter. The individual flavonoid compounds did not cause T ni. mortality in no-virus assays when incorporated into artificial insect diet. The combination of the three flavonoid compounds at leaf level concentrations significantly increased baculovirus activity in diet incorporation assays. When the daidzein, genistein, and kaempferol were added to artificial diet, at 3.5–6.5 × leaf level concentrations, virus activity increased 1.5, 2.3, and 4.2-fold for each respective flavonoid. The soybean flavonoid compounds were found to synergistically improve baculovirus activity against T. ni.
Dynamic and synchronous changes in metazoan body size during the Cambrian Explosion
Authors: Zhuravlev Andrey Yu. , Wood Rachel
Published: April 2020

Many aspects of the drivers for, and evolutionary dynamics of, the Cambrian Explosion are poorly understood. Here we quantify high-resolution changes in species body size in major metazoan groups on the Siberian Platform during the early Cambrian (ca. 540–510 Million years ago (Ma)). Archaeocyath sponges, hyolith lophophorates, and helcionelloid mollusc species show dynamic and synchronous trends over million-year timescales, with peaks in body size during the latest Tommotian/early Atbadanian and late Atdabanian/early Botoman, and notably small body sizes in the middle Atdabanian and after the Sinsk anoxic extinction event, starting ca. 513 Ma. These intervals of body size changes are also mirrored in individual species and correlate positively with increased rates of origination and broadly with total species diversity. Calcitic brachiopods (rhynchonelliformeans), however, show a general increase in body size following the increase in species diversity through this interval: phosphatic brachiopods (linguliformeans) show a body size decrease that negatively correlates with diversity. Both brachiopod groups show a rapid recovery at the Sinsk Event. The synchronous changes in these metrics in archaeocyath, hyoliths and helcionelloids suggest the operation of external drivers through the early Cambrian, such as episodic changes in oxygenation or productivity. But the trends shown by brachiopods suggests a differing physiological response. Together, these dynamics created both the distinct evolutionary record of metazoan groups during the Cambrian Explosion and determined the nature of its termination.
Gamma glutamyltransferase and risk of dementia in prediabetes and diabetes
Authors: Han Eugene , Lee Ji-Yeon , Han Kyung-do , Cho Hanna , Kim Kwang Joon , Lee Byung-Wan , Kang Eun Seok , Cha Bong-Soo , Younossi Zobair M , Lee Yong-ho
Published: April 2020

Diabetes is associated with cognitive impairment and greater risk for dementia, but the role of gamma-glutamyltransferase (γ-GT) in dementia has not been elucidated. We determined incident dementia including Alzheimer’s disease and vascular dementia, analyzing data from participants aged 40 years or older in the National Health Insurance Database, collected by the National Health Insurance Service in Korea, from January 2009 to December 2015. During a median follow-up of 7.6 years, 272,657 participants were diagnosed as having dementia. Higher serum γ-GT was associated with increased risk of dementia (HR = 1.22, 95% CI = 1.20–1.24), and had a strong positive association with early onset dementia (HR = 1.32, 95% CI = 1.24–1.40). An additive impact of higher γ-GT on dementia was observed regardless of glycemic status, and prevalent diabetes with the highest γ-GT quartile had a 1.8-fold increased dementia risk (HR = 1.82, 95% CI = 1.78–1.85). This effect of γ-GT concentration in diabetes was more prominent in individuals with vascular dementia (HR = 1.94, 95% CI = 1.84–2.04). In subgroup analysis, young age, male sex, and relatively healthy subjects with a higher γ-GT quartile had more increased dementia risk. In conclusion, γ-GT concentration as well as glycemic status could be a future risk factor for dementia in the general population.
Establishment and characterization of 18 human colorectal cancer cell lines
Authors: Kim Soon-Chan , Kim Hyun-Soo , Kim Jae Hyeon , Jeong Nahyun , Shin Young-Kyoung , Kim Min Jung , Park Ji Won , Jeong Seung-Yong , Ku Ja-Lok
Published: April 2020

Colorectal cancer (CRC) represents the third most frequently diagnosed malignancy worldwide and is the second most common cause of tumor-associated mortalities in Korea. Due to the disease’s aggressive behavior, the 5-year survival rate for CRC patients remains unpromising. Well-characterized cell lines have been used as a biological model for studying the biology of cancer and developing novel therapeutics. To assist in vitro studies, 18 CRC cell lines (SNU-1566, SNU-1983, SNU-2172, SNU-2297, SNU-2303, SNU-2353B, SNU-2359, SNU-2373B, SNU-2407, SNU-2423, SNU-2431, SNU-2465, SNU-2493, SNU-2536C, SNU-2621B, SNU-NCC-61, SNU-NCC-376, and SNU-NCC-377) derived from Korean patients were established and characterized in the present study. General characteristics of each cell line including doubling time, in vitro morphology, mutational profiles, and protein expressions of CRC-related genes were described. Whole exome sequencing was performed on each cell line to configure mutational profiles. Single nucleotide variation, frame shift, in-frame deletions and insertions, start codon deletion, and splice stop codon mutation of various genes were found and classified based on their pathogenicity reports. In addition, cell viability was assayed to measure their sensitivities to 24 anti-cancer drugs including anti-metabolites, kinase inhibitors, histone deacetylase inhibitors, alkylating inhibitors, and topoisomerase inhibitors, all widely used for various cancers. On testing, five CRC cell lines showed MSI, of which MLH1 or MSH6 gene was mutated. These newly established CRC cell lines can be used to investigate biological characteristics of CRC, particularly for investigating gene alterations associated with CRC.
Delayed effects of acute whole body lethal radiation exposure in mice pre-treated with BBT-059
Authors: Sharma Neel K. , Holmes-Hampton Gregory P. , Kumar Vidya P. , Biswas Shukla , Wuddie Kefale , Stone Sasha , Aschenake Zemenu , Wilkins William L. , Fam Christine M. , Cox George N. , Ghosh Sanchita P.
Published: April 2020

The threat of nuclear exposure is heightened and it is imperative to identify potential countermeasures for acute radiation syndrome. Currently no countermeasures have been approved for prophylactic administration. Effective countermeasures should function to increase survival in the short term as well as to increase the overall prognosis of an exposed individual long term. Here we describe the use of a promising radiation countermeasure, BBT-059, and the results of a long term mouse study (up to 12 months) in the male CD2F1 strain using 60Co gamma irradiation (~0.6 Gy/min, 7.5–12.5 Gy). We report the dose reduction factor of 1.28 for BBT-059 (0.3 mg/kg) compared to control administered 24 h prior to irradiation. In the long term study animals showed accelerated recovery in peripheral blood cell counts, bone marrow colony forming units, sternal cellularity and megakaryocyte numbers in drug treated mice compared to formulation buffer. In addition, increased senescence was observed in the kidneys of animals administered control or drug and exposed to the highest doses of radiation. Decreased levels of E-cadherin, LaminB1 and increased levels of Cyc-D and p21 in spleen lysates were observed in animals administered control. Taken together the results indicate a high level of protection following BBT-059 administration in mice exposed to lethal and supralethal doses of total body gamma-radiation.
A prospective study comparing water only with positive oral contrast in patients undergoing abdominal CT scan
Authors: de Wit Pascale A. M. , Tielbeek Jeroen A. W. , van Diepen Pascal R. , Oulad Abdennabi Ikrame , Beenen Ludo F. M. , Bipat Shandra
Published: April 2020

Consecutive adults scheduled to undergo abdominal CT with oral contrast were asked to choose between 1000 ml water only or positive oral contrast (50 ml Télébrix-Gastro diluted in 950 ml water). Two abdominal radiologists independently reviewed each scan for image quality of the abdomen, the diagnostic confidence per system (gastrointestinalsystem/organs/peritoneum/retroperitoneum/lymph nodes) and overall diagnostic confidence to address the clinical question (not able/partial able/fully able). Radiation exposure was extracted from dose reports. Differences between both groups were evaluated by Student’s t-test, Mann-Whitney-U-test or chi-square-test. Of the 320participants, 233chose water only. All baseline characteristics, image quality of the abdomen and the diagnostic confidence of the organs were comparable between groups and both observers. Diagnostic confidence in the water only group was more commonly scored as less than good by observer1. The results were as follows: the gastrointestinal system(18/233vs1/87; p = 0.031), peritoneum (21/233vs1/87; p = 0.012), retroperitoneum (11/233vs0/87; p = 0.040) and lymph nodes (11/233vs0/87; p = 0.040). These structures were scored as comparable between both groups by observer2. The diagnostic confidence to address the clinical question could be partially addressed in 6/233 vs 0/87 patients (p = 0.259). The water only group showed a tendency towards less radiation exposure. In summary, most scan ratings were comparable between positive contrast and water only, but slightly favored positive oral contrast for one reader for some abdominal structures. Therefore, water only can replace positive oral contrast in the majority of the outpatients scheduled to undergo an abdominal CT.
Assessing the motivation to learn in cattle
Authors: Meagher Rebecca K. , Strazhnik Emma , von Keyserlingk Marina A. G. , Weary Daniel M.
Published: April 2020

Cognitive challenges may provide a form of enrichment to improve the welfare of captive animals. Primates, dolphins, and goats will voluntarily participate in learning tasks suggesting that these are rewarding, but little work has been conducted on livestock species. We investigated the motivation of 10 pairs of Holstein heifers to experience learning opportunities using a yoked design. All heifers were trained to perform an operant response (nose touch) on a variable interval schedule. Learning heifers then performed this response to access a discrimination learning task in which colour and texture of feed-bin lids signified a preferred reward (grain) vs. a non-preferred reward (straw). Control heifers received the same feed without a choice of bins or association of feed with lid type. Learning heifers approached the target to begin sessions faster (p = 0.024) and tended to perform more operant responses (p = 0.08), indicating stronger motivation. Treatments did not differ in the frequency with which heifers participated in voluntary training sessions. We conclude that heifers are motivated to participate in learning tasks, but that aspects of the experience other than discrimination learning were also rewarding. Cognitive challenges and other opportunities to exert control over the environment may improve animal welfare.
Author Correction: Quantitative biparametric analysis of hybrid 18F-FET PET/MR-neuroimaging for differentiation between treatment response and recurrent glioma
Authors: Lohmeier Johannes , Bohner Georg , Siebert Eberhard , Brenner Winfried , Hamm Bernd , Makowski Marcus R.
Published: April 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Telomere shortening associates with elevated insulin and nuchal fat accumulation
Authors: Mangge Harald , Herrmann Markus , Almer Gunter , Zelzer Sieglinde , Moeller Reinhard , Horejsi Renate , Renner Wilfried
Published: April 2020

Obesity and relative leucocyte telomere length (RTL) are both linked to accelerated aging and premature mortality. We examined if nuchal subcutaneous adipose tissue (SAT) thickness, a surrogate marker of central trunk-weighted obesity, is an independent predictor of RTL that provides information beyond BMI, metabolic and inflammatory markers. RTL and nuchal SAT thickness were determined in 362 participants of the STYJOBS/EDECTA study (STYrian Juvenile Obesity Study, Early DEteCTion of atherosclerosis), which included overweight individuals and matched eutrophic controls. Fasting plasma samples were used for the measurement of leptin, resistin, adiponectin, glucose, insulin, high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), liver enzymes, creatinine, cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, oxidized LDL, triglycerides, homocysteine and uric acid. Furthermore, all participants underwent carotid artery ultrasound. Obese individuals had markedly higher body mass index (BMI), nuchal SAT thickness, hip and waist circumferences and carotid intima media thickness (IMT) than eutrophic controls. In addition, they showed typical biochemical abnormalities related to energy metabolism, systemic inflammation and liver function. RTL was inversely correlated with nuchal SAT thickness, IMT, hs-CRP, alkaline phosphatase, insulin, resistin, and leptin. Positive correlations were seen with homocysteine and creatinine. Stepwise linear regression analyses identified nuchal SAT thickness and insulin as the only significant predictors of RTL. In conclusion, nuchal SAT thickness is a robust predictor of RTL that provides information beyond traditional obesity-related metabolic and inflammatory biomarkers. This suggests an important role of fat depots at the neck for accelerated telomere shortening.
A proximity-labeling proteomic approach to investigate invadopodia molecular landscape in breast cancer cells
Authors: Thuault Sylvie , Mamelonet Claire , Salameh Joëlle , Ostacolo Kevin , Chanez Brice , Salaün Danièle , Baudelet Emilie , Audebert Stéphane , Camoin Luc , Badache Ali
Published: April 2020

Metastatic progression is the leading cause of mortality in breast cancer. Invasive tumor cells develop invadopodia to travel through basement membranes and the interstitial matrix. Substantial efforts have been made to characterize invadopodia molecular composition. However, their full molecular identity is still missing due to the difficulty in isolating them. To fill this gap, we developed a non-hypothesis driven proteomic approach based on the BioID proximity biotinylation technology, using the invadopodia-specific protein Tks5α fused to the promiscuous biotin ligase BirA* as bait. In invasive breast cancer cells, Tks5α fusion concentrated to invadopodia and selectively biotinylated invadopodia components, in contrast to a fusion which lacked the membrane-targeting PX domain (Tks5β). Biotinylated proteins were isolated by affinity capture and identified by mass spectrometry. We identified known invadopodia components, revealing the pertinence of our strategy. Furthermore, we observed that Tks5 newly identified close neighbors belonged to a biologically relevant network centered on actin cytoskeleton organization. Analysis of Tks5β interactome demonstrated that some partners bound Tks5 before its recruitment to invadopodia. Thus, the present strategy allowed us to identify novel Tks5 partners that were not identified by traditional approaches and could help get a more comprehensive picture of invadopodia molecular landscape.
Author Correction: Genetic structure of Mycoplasma ovipneumoniae informs pathogen spillover dynamics between domestic and wild Caprinae in the western United States
Authors: Kamath Pauline L. , Manlove Kezia , Cassirer E. Frances , Cross Paul C. , Besser Thomas E.
Published: April 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Pretreatment of ovaries with collagenase before vitrification keeps the ovarian reserve by maintaining cell-cell adhesion integrity in ovarian follicles
Authors: Kawai Tomoko , Shimada Masayuki
Published: April 2020

The mammalian ovarian follicle is comprised of the germ cell or oocyte surrounded by the somatic cells, the granulosa and theca cells. The ovarian stroma, including the collagen-rich matrix that supports the three-dimensional disk-like follicular structure, impacts the integrity of the ovarian follicle and is essential for follicular development. Maintaining follicular integrity during cryopreservation has remained a limiting factor in preserving ovarian tissues for transplantation because a significant proportion of developed follicles in the frozen-thawed ovaries undergo atresia after transplantation. In this study, we show for the first time that during vitrification of the mouse ovary, the attachment of the oocyte to the granulosa cells was impaired by the loss of the cadherin adhesion molecules. Importantly, exposure to a high osmotic solution greatly decreased the ratio of oocyte diameter to the diameter of its follicle but did not alter the collagen-rich matrix surrounding the follicles. By treating ovaries briefly with collagenase before exposure to the hyper-osmotic solution the ratio of oocyte diameter to follicle diameter was maintained, and cadherin adhesion junctions were preserved. When frozen-thawed ovaries were transplanted to the bursa of recipient hosts, pretreatment with collagenase significantly increased serum levels of AMH, the number of intact follicles and the total number of viable offspring compared to frozen-thawed ovaries without collagenase pretreatment, even 6 months after transplantation. Thus, the collagenase pretreatment could provide a beneficial approach for maintaining the functions and viability of cryopreserved ovaries in other species and clinically relevant situations.
Orthosteric muscarinic receptor activation by the insect repellent IR3535 opens new prospects in insecticide-based vector control
Authors: Moreau Eléonore , Mikulska-Ruminska Karolina , Goulu Mathilde , Perrier Stéphane , Deshayes Caroline , Stankiewicz Maria , Apaire-Marchais Véronique , Nowak Wieslaw , Lapied Bruno
Published: April 2020

The insect repellent IR3535 is one of the important alternative in the fight against mosquito-borne disease such as malaria, dengue, chikungunya, yellow fever and Zika. Using a multidisciplinary approach, we propose the development of an innovative insecticide-based vector control strategy using an unexplored property of IR3535. We have demonstrated that in insect neurosecretory cells, very low concentration of IR3535 induces intracellular calcium rise through cellular mechanisms involving orthosteric/allosteric sites of the M1-muscarinic receptor subtype, G protein βγ subunits, background potassium channel inhibition generating depolarization, which induces voltage-gated calcium channel activation. The resulting internal calcium concentration elevation increases nicotinic receptor sensitivity to the neonicotinoid insecticide thiacloprid. The synergistic interaction between IR3535 and thiacloprid contributes to significantly increase the efficacy of the treatment while reducing concentrations. In this context, IR3535, used as a synergistic agent, seems to promise a new approach in the optimization of the integrated vector management for vector control.
Hemodynamic effects of Vernakalant in cardio-surgical ICU-patients treated for recent-onset postoperative atrial fibrillation
Authors: Schnaubelt S. , Niederdöckl J. , Simon A. , Schütz N. , Holaubek C. , Edlinger-Stanger M. , Niessner A. , Steinlechner B. , Sulzgruber P. , Spiel A. O. , Domanovits H.
Published: April 2020

Postoperative atrial fibrillation (POAF) is one of the most frequent complications after cardiothoracic surgery and a predictor for postoperative mortality and prolonged ICU-stay. Current guidelines suggest the multi-channel inhibitor Vernakalant as a treatment option for rhythm control. However, rare cases of severe hypotension and cardiogenic shock following drug administration have been reported. To elucidate the impact of Vernakalant on hemodynamics, we included ten ICU patients developing POAF after elective cardiac surgery, all of them awake and breathing spontaneously, in this prospective trial. Patients received the recommended dosage of Vernakalant and were clinically observed and monitored (heart rate, invasive blood pressure, pulse oximetry, central venous pressure) in 1-minute-intervals for 20 minutes before- and 120 minutes after the first dose of Vernakalant. The median time from the end of surgery until occurrence of POAF amounted up to 52.8 [45.9–77.4] hours, it took 3.5 [1.2–10.1] hours from occurrence of POAF until the first application of Vernakalant. All patients received catecholamine support with epinephrine that was held steady and not dynamic throughout the observational phase. We noted stable hemodynamic conditions, with a trend towards a reduction in heart rate throughout the 120 minutes after drug administration. In 7 patients (70%), conversion to sustained sinus rhythm (SR) occurred within 8.0 minutes [6.0–9.0]. No serious adverse events (SAEs) were noted during the observation period. In this prospective trial in ICU-patients showing POAF after cardiac surgery, intravenous Vernakalant did not induce clinically relevant negative effects on patients’ hemodynamics but resulted in conversion to sustained SR after a median of 8.0 minutes in 7 out of ten patients.
Author Correction: Asthma and/or hay fever as predictors of fertility/impaired fecundity in U.S. women: National Survey of Family Growth
Authors: Turkeltaub Paul C. , Lockey Richard F. , Holmes Katie , Friedmann Erika
Published: April 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Core–shell particles for drug-delivery, bioimaging, sensing, and tissue engineering
Authors: Jenjob Ratchapol , Phakkeeree Treethip , Crespy Daniel
Published: April 2020

Core–shell particles offer significant advantages in their use for bioimaging and biosensors.
Humin based resin for wood modification and property improvement
Authors: Sangregorio Anna , Muralidhara Anitha , Guigo Nathanael , Thygesen Lisbeth G. , Marlair Guy , Angelici Carlo , de Jong Ed , Sbirrazzuoli Nicolas
Published: April 2020

Focus on humins, a co-product from sugar conversion, to highlight their capacity to impregnate wood cell walls for making durable wood products.
Catalytic activity of Mg–Al hydrotalcites and derived mixed oxides for imination reactions via an oxidative-dehydrogenation mechanism
Authors: Vala Naresh , Joshi Pradyuman A. , Mishra Manish
Published: April 2020

A Mg–Al hydrotalcite derived mixed oxide (Mg/Al ratio = 3.0) showed excellent catalytic activity in imination and tandem reactions via an oxidative-dehydrogenation mechanism.
Ligand engineering of immobilized nanoclusters on surfaces: ligand exchange reactions with supported Au11(PPh3)7Br3
Authors: Truttmann Vera , Herzig Christopher , Illes Ivonne , Limbeck Andreas , Pittenauer Ernst , Stöger-Pollach Michael , Allmaier Günter , Bürgi Thomas , Barrabés Noelia , Rupprechter Günther
Published: April 2020

Ligand exchange on Au nanoclusters has been proven to be a powerful tool for tuning their properties, but has so far been limited to dissolved clusters in solution. Within this work, ligand exchange has been extended to supported Au11 nanoclusters.
The key entity of a DCAR agonist, phosphatidylinositol mannoside Ac1PIM1: its synthesis and immunomodulatory function
Authors: Arai Yohei , Torigoe Shota , Matsumaru Takanori , Yamasaki Sho , Fujimoto Yukari
Published: April 2020

We achieved the first synthesis of phosphatidylinositol mannoside Ac1PIM1, and a very potent agonist of an innate immune receptor DCAR is demonstrated.
Sustained in vitro interferon-beta release and in vivo toxicity of PLGA and PEG-PLGA nanoparticles
Authors: Fodor-Kardos Andrea , Kiss Ádám Ferenc , Monostory Katalin , Feczkó Tivadar
Published: April 2020

Interferon-beta-1a (IFN-β-1a) can diminish the symptoms of relapsing-remitting multiple sclerosis.
Variational model for a rippled graphene sheet
Authors: Aljedani Jabr , Chen Michael J. , Cox Barry J.
Published: April 2020

A variational model is proposed to describe rippled graphene on a substrate, and obtain the relationship between total energy and substrate length.
Isolation ssDNA aptamers specific for both live and viable but nonculturable stateVibrio vulnificususing whole bacteria-SEILEX technology
Authors: Liu Dejing , Hu Bo , Peng Dingfa , Lu Shan , Gao Shunxiang , Li Zhengang , Wang Lianghua , Jiao Binghua
Published: April 2020

With whole-bacteria SELEX, we got aptamers that can bind toV. vulnificusin VBNC Status for the first time.
Logic-signal-based multiplex detection of MiRNAs with high tension hybridization and multiple signal amplification
Authors: Tang Yaqin , He Xiao , Yuan Rui , Liu Xingming , Zhao Yi , Wang Tingting , Chen Hui , Feng Xuli
Published: April 2020

A multiplex miRNA detection scheme with simultaneous multiple signal output by single excitation has been reported.
The design and synthesis of two imidazole fluorescent probes for the special recognition of HClO/NaHSO3 and their applications
Authors: Ding Hong-Lin , Pu Yan-Qing , Ye Da-Ying , Dong Zi-Yue , Yang Man , Lü Cheng-Wei , An Yue
Published: April 2020

The design and synthesis of two imidazole fluorescent probes for the special recognition of HClO/NaHSO3 and their applications are shown.
Protein cages and virus-like particles: from fundamental insight to biomimetic therapeutics
Authors: Steinmetz Nicole F. , Lim Sierin , Sainsbury Frank
Published: April 2020

Protein cages found in nature have evolved for a variety of purposes and this review focuses on how they are being co-opted for use in immunotherapy and therapeutic delivery.
Modulating neutrophil extracellular traps for wound healing
Authors: Kaur Tejinder , Dumoga Shweta , Koul Veena , Singh Neetu
Published: April 2020

An alginate-GelMa scaffold for modulating neutrophil extracellular traps using a PAD4 inhibitor could be a novel therapeutic approach for wound healing.
A multifunctional metal-biopolymer coordinated double network hydrogel combined with multi-stimulus responsiveness, self-healing, shape memory and antibacterial properties
Authors: Yan Kun , Xu Feiyang , Wang Chunyu , Li Yingying , Chen Yuanli , Li Xiufang , Lu Zhentan , Wang Dong
Published: April 2020

A universal, straightforward macroscale assembly technology has been presented for fabrication of polysaccharide-based multifunctional DN gels based on metal coordination chemistry.
A novel design strategy of a practical carbon anode material from a single lignin-based surfactant source for sodium-ion batteries
Authors: Li Changhao , Sun Yi , Wu Qiujie , Liang Xin , Chen Chunhua , Xiang Hongfa
Published: April 2020

A schematic illustration showing the preparation of HCM from a single sodium lignin sulfonate source and the process of Na storage.
A difluoroboron β-diketonate based thermometer with temperature-dependent emission wavelength
Authors: Wang Jian-Xin , Yu Yi-Shuai , Niu Li-Ya , Zou Bo , Wang Kai , Yang Qing-Zheng
Published: April 2020

Difluoroboron β-diketonate complexes that manifested temperature-dependent emission wavelength are reported.
Ba6BO3Cl9and Pb6BO4Cl7: structural insights intoortho-borates with uncondensed BO4tetrahedra
Authors: Li Wei , Wu Hongping , Yu Hongwei , Hu Zhanggui , Wang Jiyang , Wu Yicheng
Published: April 2020

Two new halogen-richortho-borates, Ba6BO3Cl9and Pb6BO4Cl7, were synthesized and characterized. Interestingly, Pb6BO4Cl7contains rare uncondensed BO4tetrahedra.
Identifying the role of excess electrons and holes for initiating the photocatalytic dissociation of methanol on a TiO2(110) surface
Authors: Yu Fengdu , Hu Ziyu
Published: April 2020

As a prototype for the catalytic oxidation of organic contaminants, photocatalytic methanol dissociation on rutile TiO2(110) has drawn much attention, but its reaction mechanism remains elusive.
Direct imaging of direction-controlled molecular rotational wave packets created by a polarization-skewed double-pulse
Authors: Mizuse Kenta , Sakamoto Naoya , Fujimoto Romu , Ohshima Yasuhiro
Published: April 2020

High-resolution molecular movies of direction-controlled rotational wave packets are reported, providing insights into the creation process and detailed dynamics of wave packets.
Photon-mediated charge exchange reactions between 39K atoms and 40Ca+ ions in a hybrid trap
Authors: Li Hui , Jyothi S. , Li Ming , Kłos Jacek , Petrov Alexander , Brown Kenneth R , Kotochigova Svetlana
Published: April 2020

We present experimental evidence of charge exchange between laser-cooled potassium 39K atoms and calcium 40Ca+ ions in a hybrid atom–ion trap and give quantitative theoretical explanations for the observations.
Complementary interpretation of ET(30) polarity parameters of ionic liquids
Authors: Spange Stefan , Lienert Caroline , Friebe Nadine , Schreiter Katja
Published: April 2020

The ET(30) parameter of ionic liquids is determined by the hydrogen bond donating ability of the cation and the number of dipole ion pairs per volume.
Impact of edge structures on interfacial interactions and efficient visible-light photocatalytic activity of metal–semiconductor hybrid 2D materials
Authors: Singh Deobrat , Panda Pritam Kumar , Khossossi Nabil , Mishra Yogendra Kumar , Ainane Abdelmajid , Ahuja Rajeev
Published: April 2020

The present work systematically investigates the structural, electronic, and optical properties of MoS2/Si2BN heterostructures based on first-principles calculations.
From cellulose to 1,2,4-benzenetriol via catalytic degradation over a wood-based activated carbon catalyst
Authors: Wu Qiong , Zhao Baozheng , Liu Shiwei , Yu Shitao , Huang Lang , Ragauskas Arthur J.
Published: April 2020

1,2,4-Benzenetriol was obtained from cellulose hydrothermal degradation using phosphoric acid-activated wood-based AC as the catalyst.
Site-specific catalytic activities to facilitate solvent-free aerobic oxidation of cyclohexylamine to cyclohexanone oxime over highly efficient Nb-modified SBA-15 catalysts
Authors: Ding Wei , Peng Haoyu , Zhong Wenzhou , Mao Liqiu , Yin Dulin
Published: April 2020

The development of highly active and selective heterogeneous catalysts for efficient oxidation of cyclohexylamine to cyclohexanone oxime is a challenge associated with the highly sensitive nitrogen center of cyclohexylamine.
Bimetallic scorpionate-based helical organoaluminum complexes for efficient carbon dioxide fixation into a variety of cyclic carbonates
Authors: Navarro Marta , Sánchez-Barba Luis F. , Garcés Andrés , Fernández-Baeza Juan , Fernández Israel , Lara-Sánchez Agustín , Rodríguez Ana M.
Published: April 2020

The binuclear aluminum complexes [AlR2(κ2-NN′;κ2-NN′)AlR2] with TBAB/PPNCl behave as excellent systems for cyclic carbonate formation from CO2with challenging epoxides.
On the formation of the Gd3Ru4Al12versusthe Y2Co3Ga9type structure – M3Rh4Al12(M = Ca, Eu)versusM2T3Al9(M = Ca, Sr, Eu, Yb; T = Ir, Pt)
Authors: Stegemann Frank , Zhang Yuemei , Fokwa Boniface P. T. , Janka Oliver
Published: April 2020

Structure, bonding and stability investigations of seven new ternary alkaline-earth transition metal aluminum intermetallics.
Syntheses, characterization and properties of two new dodeca-niobates presenting unprecedented features
Authors: Zhang Ting-Ting , Lin Po-Han , Yu Gui-Yang , Zhang Xiao , Cui Xiao-Bing
Published: April 2020

Two new dodeca-niobate materials, K3[Nb2O2][H7SiNb12O40]·16H2O (1) and [Cu(en)2]9[(VNb12V1.69Nb0.31O42en0.31)2]·20.69H2O (2), have been obtained and characterized by IR, UV-Vis, XRD, and single crystal X-ray diffraction analysis.
Lysine inhibits apoptosis in satellite cells to govern skeletal muscle growthviathe JAK2-STAT3 pathway
Authors: Song Zhi-wen , Jin Cheng-long , Ye Mao , Gao Chun-qi , Yan Hui-chao , Wang Xiu-qi
Published: April 2020

Apoptosis is programmed cell death that can be stimulated by external stress or nutrition restrictions.
Secoisolariciresinol diglucoside alleviates hepatic lipid metabolic misalignment involving the endoplasmic reticulum–mitochondrial axis
Authors: Wei Liping , Zhao Caicai , Dong Shan , Yao Shundi , Ji Bing , Zhao Beita , Liu Zhigang , Liu Xuebo , Wang Yutang
Published: April 2020

The potential mechanism of SDG against HFFD-induced insulin resistance and hepatic lipid metabolic disorders in mice.
Curcumin micelles suppress gastric tumor cell growth by upregulating ROS generation, disrupting redox equilibrium and affecting mitochondrial bioenergetics
Authors: Lin Xiaokun , Wang Lihua , Zhao Liqian , Zhu Zheng , Chen TongZuan , Chen Shinuo , Tao Yecheng , Zeng Tianni , Zhong Yaoyao , Sun Hanxiao , Wang Zhixiang , Zheng Weisheng , Zhang Yuhao , Wu Wencan , Nan Kaihui , Chen Tongke
Published: April 2020

A proposed novel mechanism of anticancer activity of curcumin micelles through redox equilibrium in gastric cancer.
Effects of steam explosion pretreatment on the composition and biological activities of tartary buckwheat bran phenolics
Authors: Li Weizhou , Zhang Xiaoli , He Xiaoqin , Li Fuhua , Zhao Jichun , Yin Ran , Ming Jian
Published: April 2020

Steam explosion (SE) is an efficient technology to disrupt materials for improving their quality.
Lipophilic ferulic acid derivatives protect PC12 cells against oxidative damage via modulating β-amyloid aggregation and activating Nrf2 enzymes
Authors: Wu Yu , Shi Yu-gang , Zheng Xiao-liang , Dang Ya-li , Zhu Chen-min , Zhang Run-run , Fu Yu-ying , Zhou Tian-yi , Li Jun-hui
Published: April 2020

Ferulic acid (FA) has been shown to have a neuroprotective effect on Alzheimer's disease induced by amyloid-beta (Aβ) neurotoxicity.
Multiplexed homogeneous digital immunoassay based on single-particle motion analysis
Authors: Akama Kenji , Noji Hiroyuki
Published: April 2020

Homogeneous digital immunoassay is a powerful analytical method for highly sensitive biomarker detection with a simple protocol. By using this method, we demonstrated the simultaneous multiple protein detection.
MXene interlayered crosslinked conducting polymer film for highly specific absorption and electromagnetic interference shielding
Authors: Bora Pritom J. , Anil Amith G. , Ramamurthy Praveen C. , Tan Daniel Q.
Published: April 2020

In this work, the electromagnetic interference (EMI) shielding properties of an MXene interlayered crosslinked conducting poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) polymer film are investigated.
Defining the plasmonic cavity performance based on mode transitions to realize highly efficient device design
Authors: Devaraj Vasanthan , Lee Jong-Min , Lee Donghan , Oh Jin-Woo
Published: April 2020

The NPOM nanostructure with a combination of an unchanged dipolar mode and edge effect property can uplift the efficiency of devices in multiple applications.
Self-assembly of Janus Au:Fe3O4branched nanoparticles. From organized clusters to stimuli-responsive nanogel suprastructures
Authors: Reguera Javier , Flora Tatjana , Winckelmans Naomi , Rodríguez-Cabello José C. , Bals Sara
Published: April 2020

Novel suprastructures, from small clusters to micelle-like structures, are obtained by self-assembly of Janus Au:Fe3O4nanostars under external stimuli.
Assessing the role of plasma-engineered acceptor-like intra- and inter-grain boundaries of heterogeneous WS2–WO3 nanosheets for photocurrent characteristics
Authors: Gopakumar Gopika , Nair Shantikumar V. , Shanmugam Mariyappan
Published: April 2020

Acceptor-like intra-/inter-grain boundaries in heterogeneous WS2–WO3 impede its charge transport kinetics, and can be engineered via plasma treatment.
Cellulose paper support with dual-layered nano–microstructures for enhanced plasmonic photothermal heating and solar vapor generation
Authors: Huang Yintong , Morishita Yoshitaka , Uetani Kojiro , Nogi Masaya , Koga Hirotaka
Published: April 2020

Light absorption and photothermal heating performance of plasmonic nanoparticles are enhanced by a cellulose paper support with dual-layered nano/microstructures of cellulose nanofibers and pulp fibers for efficient solar vapor generation.
Effects of oxidation treatment by KClO3/H2SO4systems on the chemical, crystal and microscopic structures of polyacrylonitrile fibers
Authors: Zhang Cheng , Xiao Shijie , Shen Zhigang , Li Runping , Liu Jianhua , Guo Shenghui , Xu Lei
Published: April 2020

Oxidation treatment of PAN fibers (PFs) in a KClO3/H2SO4system as a new pretreatment method for carbon fiber oxidation stabilization.
Ultrasound-assisted extraction of bioactive alkaloids from Phellodendri amurensis cortex using deep eutectic solvent aqueous solutions
Authors: Li Yuanbin , Pan Zuchen , Wang Binshen , Yu Wen , Song Siwei , Feng Huanhuan , Zhao Weiwei , Zhang Jiaheng
Published: April 2020

ChCl/citric acid-based DESs are demonstrated to be effective green solvents for the ultrasound-assisted extraction of bioactive alkaloids from herbs.
Synthesis of one dimensional Cu2S nanorods using a self-grown sacrificial template for the electrocatalytic oxygen evolution reaction (OER)
Authors: Kale Shital B. , Babar Pravin T. , Kim Jin-Hyeok , Lokhande Chandrakant D.
Published: April 2020

The oxygen evolution reaction (OER) is critical in electrochemical water splitting and requires an efficient, sustainable, and cheap catalyst for successful practical applications.
Electrochemical detection of 2-nitroaniline at a novel sphere-like Co2SnO4 modified glassy carbon electrode
Authors: Palpandi Karuppaiya , Raman Natarajan
Published: April 2020

A novel electrochemical sensor, based on a Co2SnO4 (CoSnO) modified glassy carbon electrode (GCE), has been successfully developed for the determination of 2-nitroaniline (2-NA).
Copper(ii) complexes containing enoxacin and heterocyclic ligands: synthesis, crystal structures and their biological perspectives
Authors: Kumar Manish , Kumar Gyanendra , Masram Dhanraj T.
Published: April 2020

Two copper-based complexes with a distorted square pyramidal geometry show excellent binding and cleavage affinity towards DNA and proteins. Also, these complexes have potential cytotoxicity against MCF-7 cancer cells.
Water-soluble poly(N-isopropylacrylamide) nanoparticles grafted to trivalent lanthanide complexes as highly sensitive ratiometric nanothermometers
Authors: Sobrinho Josiane Aparecida , Brito Júnior Gilmar Araújo , Mazali Italo Odone , Sigoli Fernando Aparecido
Published: April 2020

A new water-soluble, luminescent ratiometric nanothermometer with a tunable temperature-responsive range, high thermal sensitivity and good repeatability was designed and synthesized by grafting lanthanide complexes to pNIPAM polymeric nanoparticles.
Physicochemical properties of a urea/zinc chloride eutectic mixture and its improved effect on the fast and high yield synthesis of indeno[2,1-c]quinolines
Authors: Peña-Solórzano Diana , Kouznetsov Vladimir V. , Ochoa-Puentes Cristian
Published: April 2020

An environmentally friendly and efficient method for the synthesis of indeno[2,1-c]quinolines is developed using a urea/zinc chloride eutectic mixture as a green mildly acidic medium.
Synthesis, characterization and staining performance of peripherally and non-peripherally substituted metallo-phthalocyanines bearing 1,3-bis-(trimethylamino)-2-propoxy groups
Authors: Özçeşmeci Mukaddes , Sancar Baş Serap , Akkurt Barbaros , Bolkent Şehnaz , Hamuryudan Esin
Published: April 2020

In this study, water-soluble symmetrical phthalocyanines having cationic 1,3-bis-(trimethylamino)-2-propoxy groups at the peripheral and non-peripheral positions were synthesized and characterized.