bluuebunny/crossref_metadata_2025 huggingface dataset:
Reproductive Health of Female Patients with Connective Tissue Dysplasia
Authors: Karachentsova Irina V. , Goryainova Anastasia V. , Sibirskaya Elena V. , Alekhina Marina Yu. , Askerova Amina F.
Published: July 2023

Connective tissue dysplasia is congenital anomaly manifesting as different organ's and system's alterations: locomotor, skin, visceral dysfunctions. This article presents literature review covering such topical issues as female reproductive system features affected by mesenchymal pathology (undifferentiated forms of connective tissue dysplasia) and its medicamentous management (microelements, hormonal drugs, adaptogens). The analysis of original studies on this topic has revealed that connective tissue dysplasia has significant effect on female reproductive function development and can be complicated by various menstrual dysfunctions (hypomenorrhea syndrome, oligomenorrhea, opsomenorrhea, uterine bleedings, and secondary amenorrhea) as well as by endocrine changes (anti-Mullerian hormone deficiency, hypoprolactinaemia, hypoestrogenemia, etc.). Gestation and delivery features in patients with connective tissue dysplasia (preeclampsia, premature birth, and fetal abnormalities) were also revealed.
Cobalt-supported activated biochar in the co-pyrolysis of cattle manure and rice husk
Authors: Qiu Wen , Liu Ying , Tian Longjin , Fan Guozhi , Song Guangsen , Cheng Qunpeng
Published: July 2023

It is crucial to develop an efficient catalyst for catalytic co-pyrolysis. In this paper, the catalytic co-pyrolysis of cattle manure and rice husk over a catalyst loaded with cobalt (Co) using potassium hydroxide-activated biochar as the support was conducted in a two-stage fixed-bed reactor. The results showed that the cobalt/potassium rice husk char (KRHC) catalyst displayed a good catalytic pyrolysis process with a large specific surface area and a developed pore structure. Loading with cobalt not only improved the quality of syngas but also increased syngas yield. Hydrogen content increased from 4.55 to 13.68% and carbon monoxide content increased from 19.78 to 32.25%, whereas carbon dioxide content decreased from 7.32 to 5.3% and methane content decreased from 8.01 to 6.07%. Syngas yield increased from 3.68 to 4.58 N m3/kg. The catalyst promoted the breaking of C–C and C–O bonds in tar, increased the content of phenols, ketones and aldehydes, and reduced the content of oxygen in the syngas. The catalysts also maintained good performance after five catalytic cycles, with hydrogen and carbon monoxide contents of approximately 10 and 27.5%, respectively.
Rule capture of automated compliance checking of building requirements: a review
Authors: Zhang Zijing , Ma Ling , Broyd Tim
Published: July 2023

In the architectural, engineering and construction industry, building design needs to be checked against regulations before it can be finalised and progress to the construction stage. The traditional manual compliance-checking process is error prone and time consuming. As a solution, automated compliance checking (ACC) was proposed. Rule capture is a crucial bottleneck of ACC. Despite many studies in this domain, no research has synthesised the themes and identified future research opportunities. This paper aims to fill this gap by conducting a systematic literature review and identifying challenges facing this field. The findings revealed that the rule capture process had attracted interest in the past years, and more semi-automated and automated methods have been proposed. The current representation development process lacks a methodological backdrop. The existing representations cannot represent ‘unknowns’ and ‘side effects’, lack the ability to deal with ambiguous rules and are typically restricted by the rule engine and/or target data model. The understanding of rules, representations and the relationships between them is insufficient. Further research is required to address these issues.
Ceo’s Financial Sophistication and R&D Investments
Authors: Silva Márcio Fernando da , Bortoli Cassiana , Paiva Azevedo Francisco Gleisson , Oliveira Soares Rodrigo
Published: July 2023

This study analyzed the relationship between CEO’s Financial Sophistication (FS) and the investments made in Research and Development (R&D), disclosed in the profit and loss statement and intangible assets. To this end, data were collected from companies listed on B3 from 2011 to 2019 on R&D and the personal characteristics of the CEO (experiences and training) from various sources. Factor analysis methods, probit regression models, and panel data with fixed effects were used for the analyses. It was found that, of the total sample, less than 20% of companies spend on R&D. Among the economic sectors, what most invest resources in R&D is information technology. As for the CEO’s FS, the evidence found does not confirm the hypothesis of the relationship with R&D. However, the tests conducted with the academic and professional dimensions of FS pointed out that the CEO with higher levels of the professional dimension is likely to disclose R&D in the profit and loss statement. In contrast, the academic dimension of the FS has a weak negative relationship with levels of resources applied in R&D and recorded in the intangible assets.
Estimation of multistage hydraulic fracturing parameters using 4D simulation
Authors: Bosikov I. I. , Klyuev R. V. , Silaev I. V. , Pilieva D. E.
Published: July 2023

At the present stage, most oil and gas condensate fields in the southern part of the East Siberian oil and gas province are characterized by an increasing proportion of difficult oil reserves in tight reservoirs. Multistage hydraulic fracturing (MHF) is proposed for the offshore Challenger Sea field (Southeast Dome). The implementation of this technique at a shelf will be a source of additional risks. For example, the properties of the RR-2 overlying seal have not been unambiguously assessed, and there are a number of geological uncertainties, such as the tectonic regime. However, there are a number of arguments in favor of MHF: heterogeneity of the reservoir; low permeability; low water cut of the field; sufficient thickness of the pay zone; and the overlying seal. One more positive factor is that sand ingress is not observed in the process of oil production. The selection of a principal well completion scheme on the eastern side of the RR-7 formation is aimed at effectively recovering the remaining reserves. The objectives of the study performed are: to create a geological and hydrodynamic model of the Challenger Sea (Southeast Dome); develop 1D and 3D geomechanical models; evaluate oil production forecasts based on fundamentally different well completion schemes; and determine the optimum parameters for multistage hydraulic fracturing. The research methods included: petrophysical methods; logging methods; core studies; drilling reports and formation testing data; and 3D, 4D geomechanical simulation. Other geophysical methods included acoustic logging, density logging, and gamma-ray logging. After building a geomechanical model of the reservoir at the beginning of drilling, a hydrodynamic calculation was performed. This established the reservoir pressures and saturations at certain points in time. The results made it possible for the principal stress directions, the values of effective and principal stresses, and the values of elastic strains to be determined. In order to assess MGF process efficiency, production forecasts were made using a hydrodynamic model for an exploration well with conventional completion (perforated liner) and with five-stage MGF. In the first case, the accumulated production was 144 kt over 15 years, and in the second case, 125 kt over 17 years. The difference in cumulative production is due to different initial well flow rates, as well as the rate of oil withdrawal during the first few years of development. Thereafter, the production and daily flow rate curves showed similar behavior. In order to select the most effective option, an economic analysis of the efficiency was performed.
Russian zirconium industry: current issues in raw material supply
Authors: Khatkov V. Yu. , Boyarko G. Yu. , Bolsunovskaya L. M. , Dibrov A. M. , Dibrova Yu. A.
Published: July 2023

The relevance of the research is connected with Russia’s long-term import dependence on zirconium raw materials.

Goal of this research: to study the dynamics of commodity flows (production, import, export, consumption) of Russian zirconium raw materials; its prices (world and Russian); the raw material base of zirconium in Russia and the prospects for national production of its extraction and processing.

Methods: statistical, graphic, logical.

Results: Russia imports the vast majority (3.5–14.9 kt/year or 98–100 % of consumption) of consumed zircon concentrate. At the same time, almost all of the baddeleyite mined in Russia (4.0–9.3 kt/year or (96–100 % of production) is exported. Since 2018 has there been a decrease in its export supplies and an increase in the national consumption (up to 60 % of production).

Russia has existing deposits, including a useful zirconium component, but all are connected with a certain economic and technological complexity in their development.

In 2022, the national production of selective zircon concentrate began during the development of the Tugan titanium-zirconium deposit. This deposit covers up to 30 % of Russia’s demand for zirconium raw materials up to 2023. Furthermore, the construction of the 2-nd stage of the Tugan mining and processing plant will increase its supply to 15 kt/year. This will completely cover Russian demand for zirconium raw materials. Work is in progress on Zashikhinsky field preparation, where, in the course of enrichment of tantalum-rare-earth ores, up to 8 kt/year of zircon concentrate will be additionally extracted. The emerging trend of reducing Russia’s import dependence on zirconium raw materials, and in the future its complete elimination will allow consumption of zircon and zirconium oxides to be increased in the most demanding area of their use – for dampening the glaze of ceramic tiles. The presence of an independent and sufficient national mining base of zirconium raw materials will allow Russian production of metal zirconium, zirconium refractory and abrasive products, solid fuel energy cells and other zirconiumcontaining applications to be developed.
Relevancia de la tradición oral en la narración oral urbana contemporánea.
Authors: Fernández García Irene
Published: July 2023

El artículo se propone analizar la relación que con el relato de tradición oral tienen las narradoras y narradores «urbanos y contemporáneos» (profesionales que durante las últimas décadas han visibilizado la práctica de la narración en diferentes espacios culturales y educativos) que residen en Argentina y España. Se atiende al grado de presencia que tienen los relatos de tradición oral en los repertorios y a los modos en que son transmitidos y seleccionados, con especial atención al carácter de las fuentes. Ello nos lleva a profundizar en la consideración que este material tiene dentro de la profesión y a plantear si la narración de estos relatos en un contexto urbano y contemporáneo implica su revitalización.
Quantitative ratio of mRNA expression of IGF/INS system receptors in multiple myeloma
Authors: Shushanov S. S. , Chernykh Yu. B. , Zakharova T. A. , Akentieva N. P.
Published: July 2023

Background. Individuals with increased expression of components of the IGF/INS system, are more likely to develop various malignancies. And in the case when the components of the IGF/INS system are overexpressed in tumors, this adversely affects the prognosis of the disease, including leading to a decrease in relapse-free survival. A characteristic feature of the IGF/INS system is the ability of the same ligands to bind to different receptors and vice versa (cross interactions) and activate different signaling pathways in the cell. This feature of the system requires an integrated approach to the study of the expression of its components, namely, the study of the quantitative ratio of the expression of individual components. The result obtained will make it possible to determine possible combinations of ligand-receptor bonds and, ultimately, will have both prognostic and evaluative value: in terms of a therapeutic target.

Aim. To establish the quantitative ratio of mRNA expression of the IGF/INS system receptors: IR-A, IR-B, IGF-1R, and IGF-2R in the IM9 lymphoblastoid cell line and in three myeloma cell lines: RPMI1640, RPMI8226, H929, and to identify frequency of expression of these receptors in the mononuclear fraction of bone marrow aspirates obtained from treated patients with multiple myeloma.

Materials and methods. We used human lymphoblastoid cells and 3 types of human myeloma cells, differing in the degree of differentiation and, as well as bone marrow aspirates obtained from 19 treated patients with stage III multiple myeloma. Expression of mRNA in cells was studied by quantitative real-time reverse transcription polymerase chain reaction and in bone marrow aspirate samples by semi-quantitative reverse transcription polymerase chain reaction.

Results. During the study, we found that within each cell line, the receptor IR-A is predominant compared to the receptor IR-B. Patients with MM have a high frequency of IR-A expression compared to IR-B. The minimum ratio of IGF-1R:IR-A and IGF-1R:IR-B mRNA is in IM9 lymphoblastoid cells, and for myeloma cells these ratios are high. The ratio of IGF-2R:IR-A is maximum for IM9 lymphoblastoid cells, and for myeloma cells this ratio is three or more times less.

Conclusion. Based on the study of the quantitative ratio of receptor mRNA, we state that in myeloma cells there is a high probability of the presence of IGF-1R/IGF-1R and IR-A/IR-A homodimers, and an IGF-1R/IR-A heterodimer. These data have both prognostic and evaluative value, since these combinations of receptors suggest a significant increase in the mitogenic effect due to activation by three ligands: IGF-1, IGF-2 and INS, which is an unfavorable factor, especially when a patient with multiple myeloma with concomitant Diabetes mellitus was prescribed insulin therapy along with chemotherapy. Based on our findings, we recommend simultaneously inhibiting both the IGF-1R receptor and the IR-A receptor as a therapeutic target.
Preparation and investigation of properties of resveratrol and solubilizers compositions
Authors: Krechetov S. P. , Maslennikova M. S. , Kuksin A. Yu. , Malinkin A. D. , Solovieva N. L. , Krasnyuk I. I.
Published: July 2023

Background. The search for technology or the use of excipients for the development of drugs containing poorly soluble pharmaceutical substances is an urgent task of pharmacy. According to the biopharmaceutical classification system, resveratrol belongs to group 4: the substance has low solubility and low permeability. Therefore, one of the priorities in the development of drugs with resveratrol is to increase its solubility and, as a result, increase its permeability. The article presents the results of physicochemical studies of resveratrol compositions with solubilizers (poloxamer 407, polysorbate 80, methyl-beta-cyclodextrin) after dissolution in a common solvent followed by evaporation.

Aim. Obtaining compositions of resveratrol with solubilizers and auxiliary formations with an exclusive study of their properties for the development of solid dosage forms.

Materials and methods. Trans-resveratrol, poloxamer 407, polysorbate 80, methyl-beta-cyclodextrin, citric and ascorbic acids, glycerin, methanol; high performance liquid chromatography, differential scanning calorimetry.

Results. Physical and chemical studies of the obtained compositions of resveratrol with excipients were carried out. Excipients used: citric and ascorbic acids for all compositions, as well as glycerin for compositions with tween 80. Stability studies were carried out under conditions of «accelerated aging», as a result of which a noticeable decrease in the amount of resveratrol was found (80 % of the original). Studies of the stability of resveratrol have shown that at low pH, inherent in the stomach, its content remains practically unchanged for two days. And at pH close to neutral, the content of resveratrol is reduced to 90 % of the original amount. The obtained results indicate the feasibility of developing drugs that promote the absorption of resveratrol in the stomach and are stored at low temperatures (in the refrigerator).

Conclusion. Compositions of resveratrol with solubilizers were obtained and the choice of excipients for the development of solid dosage forms was substantiated. Recommendations are given for obtaining solid dosage forms for each of the developed formulations and storage conditions are determined.
Improving Collaboration in Ambiguous Settings by Recognizing the Importance of a Common Domain Vocabulary: An Active Learning Exercise
Authors:   College of Business Administration Bowling Green State University, McKinney Earl , Green Steve ,   Department of Management United States Air Force Academy, Heppard Kurt ,   Department of Management United States Air Force Academy, Wu Jun ,   School of Economics and Management Tiangong University
Published: July 2023

This paper investigates the impact of an active learning exercise designed to help undergraduate IT/IS (Information Technology/Information Systems) and business students recognize the importance of a common domain vocabulary for collaboration in the ambiguous settings which will be endemic in their careers as IT/IS professionals. We provide preliminary results to promote further research. We also investigated and assessed the robustness of our learning exercise with students with high exam performance and with low performance, and with students in the US and China, all showing improved recognition of the importance of a common domain vocabulary for collaboration. We present relevant literature, provide a detailed description of our active learning exercise, discuss our preliminary findings, identify limitations, and suggest future research.
Giving to Get Well: Patients’ Willingness to Manage and Share Health Information on AI-Driven Platforms
Authors:   University of Memphis, Raddatz Nirmalee , Kettinger William ,   Powers College of Business, Clemson University, Coyne Joshua ,   Accounting Department, Texas Tech University
Published: July 2023

The digitalization of healthcare makes for the widespread availability of patient-provided data. Artificial Intelligence (AI) relies on this data. In this information-intensive environment, it is imperative to understand the contributing factors of an individual’s willingness to manage and share personal health information (PHI). Drawing from the health belief model, we identify the factors that motivate individuals to manage and share their PHI in an AI-driven health platform to obtain its intended benefits. We recognize security risks and present the use of a blockchain database as a representative means of securely managing and controlling an individual’s PHI. Data collected from a nationally representative sample of allergy sufferers indicate that the health belief model strongly predicts willingness to share PHI on a personalized AI-supported platform. Our study makes significant contributions by investigating the factors that motivate patients to use an AI-driven health platform to manage their health.
Expression profile of plasma microRNAs and target genes in patients with complicated pregnancy
Authors: Umerova M. D. , Alyadinova S. S. , Khonjonova M. J. , Balakadasheva R. A. , Menadzhiev E. E. , Kharchuk D. I. , Leus D. O. , Islyamova G. I. , Islyamova M. I. , Abkarimova S. L. , Kasabyan D. S. , Sorokina L. E.
Published: July 2023

Aim: to assess features of placental transcriptome in patients with complicated pregnancy course and outcome.

Materials and Methods. A prospective observational comparative study in parallel groups was carried out by examining 44 patients divided into three groups: group 1 included 13 pregnant women with moderate and severe preeclampsia (PE), group 2 consisted of 12 patients with fetal growth retardation (FGR), control group included 19 clinically healthy women with uncomplicated pregnancy and delivery. All women enrolled to the study underwent a comprehensive examination, including history collection, general and obstetric-gynecological examination, laboratory and instrumental studies. Special research methods were used during the study, which included placental tissue sampling followed by analyzed expression profile of 12 microRNAs using real-time polymerase chain reaction (PCR).

Results. The PCR data indicated about lack of expression for analyzed miR-210-3p, miR-320-3p, miR-1304-5p and miR-375-5p in placental tissue samples in FGR patients. No significant differences in placental miRNA levels were observed in FGR vs. PE and control group. Analysis of placenta-specific microRNAs in women with PE vs. control group showed a significantly down modulated expression level for miR-517a-3p (p = 0.025), miR-517c-3p (p = 0.036), miR-574-5p (p = 0.015) along with upregulated expression of miR-20a-5p (p = 0.046).

Conclusion. The data obtained evidence that pregnancy-related complications are characterized by specific molecular changes at placental transcriptome level.
Specialization of Judicial Activity in Foreign Legal Orders2
Authors: Pechegina Polina D. , Diakonova Maria O.
Published: July 2023

The article analyzes such a trend in the development of modern civil procedure as the specialization of judicial activity. The authors identify judiciary and judicial aspects of the specialization of judicial activity, different mechanisms of such specialization are given, their variability is justified. On the basis of the experience of different legal orders (Australia, England and Wales, Germany, India, Spain, Italy, Russia, USA, France, etc.) the forms of judicial specialization are shown. Thus, examples of functioning of independent courts for administrative, intellectual, labor, family, land, bankruptcy, financial, and patent disputes are shown. Mechanisms of judicial specialization are also formulated, in particular, branch division of procedural order of consideration and resolution of cases; division into kinds and subspecies of proceedings according to substantial-legal or procedural-legal feature; creation of procedural peculiarities of consideration and resolution of certain categories of cases caused by substantial-legal feature of a case; creation of procedural peculiarities of cases consideration in reviewing instances courts.
Estimation of maternal serum albumin at term to determine its correlation with birth weight of babies
Authors: Akter Syma , Tabassum Erina , Luna Sharmin Akter , Khatun Salma , Biswas Mitra , Begum Beauty
Published: July 2023

Background: Serum albumin is a vital laboratory indicator of nutrition status. Fetal weight depends upon the nutritional status of mothers. Indeed, the serum albumin status at term may help to assume the fetal weight. We do have not enough research-based data regarding this issue. The aim of this study was to estimate maternal serum albumin at term and to observe its correlation with the birth weight of babies.
Methods: This cross-sectional analytical study was done at department of gynaecology and obstetrics, Sir Salimullah medical college and Mitford hospital, Dhaka, Bangladesh from July 2019 to June 2020. A total of 96 mother-baby pairs were selected using purposive sampling method. Women with single full-term pregnancy based on fundal height on Naegele’s rule irrespective of any mode of delivery was included in this study. Mothers with normal albumin levels (3.6-5.2 gm/dl) were defined as group A and mothers with low albumin levels (<3.6 gm/dl) in group B. Statistical analyses of the results were obtained by using window-based computer software devised with SPSS-22.
Results: In analyzing the maternal serum albumin level, we observed that majority of the participants were with normal albumin levels which were 81% and the rest 19% of patients were low albumin levels. In this study, it was observed that more than half (56.4%) of babies were male in group A and 9 (50.0%) in group B. The majority (94.9%) of babies’ birth weights were ≥2.5 kg in group A and 4 (22.0%) in group B. The difference of birth weight was statistically significant (p<0.05) between the two groups. Maternal serum albumin was significantly associated with birth weight of babies in multivariate analysis. But negatively correlated with newborn birth weight which is statistically significant.   
Conclusions: Maternal albumin was observed to be directly proportional to the birth weight of babies.
Influence of Organizational Factors on In-House Software Quality Assurance in Strategic State Corporations in Kenya
Authors: Kimuyu James J. , Ogalo a James O. , . Kiura Selesio M
Published: July 2023

Purpose: The purpose of the study was to determine the influence of organizational factors on in-housesoftware quality assurance in Strategic state corporations in Kenya.Methodology: The study used quantitative research method and applied Survey research design. Theresearch population and target group comprised 6large Strategic state corporations, three in Transport andInfrastructure sector and three in the Energy sector. These are playing a critical to the Kenyan economyand the attainment of Vision 2030. These corporations have a combined ICT work force of approximately300 personnel. From the research population, a sample of 169 respondents was scientifically selected andadministered with questionnaires using a drop and pick method. A multiple linear regression model wasused to analyze the data using statistical package for the social sciences (SPSS).Results: The study found that 38.5% of the variation in In-house Software Quality Assurance in Strategicstate corporations can be explained by Organizational factors. The result of coefficients to the estimateswas 0.000 and hence significant at the 0.05 level of significance. This indicated that Organizational factorspositively and significantly influence In-house Software Quality Assurance in Strategic state corporations.The results also found that Government regulation had a partial intervening effect on the relationshipbetween Organizational factors and in-house Software Quality Assurance in Strategic state corporations.Unique contribution to theory, practice and policy: The findings of this study are useful to theGovernment, Strategic state corporations, Policy makers, Scholars, Software developers, IT consultantsand other state corporations. There is need to develop policies and software development frameworkthatwill be create a conducive Organizational environment that supports in-house development of qualitysoftware
Dowry, Its Causes and Consequences: A Sociological Study of Dowry Harassment and Death Cases in Aligarh District of UP
Authors: Salim Saira
Published: July 2023

Dowry refers to “the property, money, ornaments or any other form of wealth which a man or his familyreceives from his wife or her family at the time of marriage. Dowry is both a practice and a problem withIndian marriage” (Haveripeth, 2013).The practice of giving dowry was meant to assist a newly-wed coupleto start their life together with ease; however, now it has become a commercial transaction in whichmonetary considerations receive priority over the personal merits of the bride. Dowry system has given riseto many socio economic problems with very serious consequences. Numerous incidents of bride burning,harassment and physical torture of newlywed women and various kinds of pressure tactics being adopted bythe husbands/in-laws‟ pressurizing for more dowry have compelled the social reformers and theintelligentsia to give serious thoughts to various aspects associated with the institution of dowry (Sachdeva,1998).Government of India enacted “Dowry Prohibition Act” in 1961, which was further amended in 1985to control this menace. In spite of this Act, the “give and take” phenomenon of dowry is practiced widelythroughout India, irrespective of caste and class (Grantham, 2002). In many cases, when dowry amount isnot considered sufficient, the bride is often harassed, abused and tortured (Singh, 2005). Dowry relatedviolence and bride burning (dowry death) are only peculiar to our country and beside husband, his kin alsojoin together in persecuting the bride as the dowry and related customs provide a good excuse to them forhumiliating, insulting and even beating up of woman (Haveripeth, 2013)
Management as a science and art
Authors: Mrs.Rohini Gaikwad Dr.Vinaykumar Nimbalkar, Mr.Mithun Jadhav
Published: July 2023

The management itself is the iterative process which revolves under itself. This is infinite time process where each iteration gives birth to new system or new concept. One has to stir so much, so that one can feel the destination has been achieved. But the rigorous efforts are to be poured to achieve maximum gain through maximum revenue and with great efficiency. To have maximum efficiency the execution of system and  time rate of each execution of every module or segment must be efficient more than 100% and it is the high level synchronizing process amongst all steps in the final product making in entire process to execute and  to trigger at perfect time to get best possible results
Method Development and Validation of Simultaneous Estimation of Pseudoephedrine Ambroxol Desloratadine in Tablet Dosage Form and Degradation Studies By Rp-Hplc Method
Authors: Dr.K.Sujana Mohammad Mubina
Published: July 2023

A simple, Accurate, precise method was developed for the simultaneous estimation of the Pseudoephedrine, Ambroxol and Desloratadine in Tablet dosage form. Chromatogram was run through ODS 250mm x 4.6 mm, 5m. Mobile phase containing Buffer, Acetonitrie and Methanol in the ratio of 50:20A:30M was pumped through column at a flow rate of 1ml/min. Buffer used in this method was 0.01N KH2PO4 buffer at pH 3.2. Temperature was maintained at 30°C. Optimized wavelength for Pseudoephedrine and Ambroxol was 225nm. Retention time of Pseudoephedrine, Ambroxol and Desloratadine were found to be 2.417min, 4.518min and 7.464min respectively. %RSD of the Pseudoephedrine, Ambroxol and Desloratadine were and found to be 1.03 0.64 and 1.15respectively. %Recover was Obtained as 99.92%, 100.21% and 99.92% for Pseudoephedrine, Ambroxol and Desloratadine respectively. LOD, LOQ values are obtained from regression equations of Pseudoephedrine(0.01ppm, 0.02ppm), Ambroxol(0.15ppm, 1.44ppm) and Desloratadine(0.06ppm, 0.17ppm). Regression equation of Pseudoephedrine is y = 16947x + 319.2 Ambroxol is y = 19401x + 3236.and Desloratidine y = 38993x +2051.
Topological Structures on Fuzzy Multisets
Authors: Moshahary Jwngsar
Published: July 2023

In this paper the concept of fuzzy topological space extended into fuzzy multiset topological space, closed fuzzy multiset, open fuzzy multisets, interior fuzzy multisets, closure of fuzzy multisets and their various properties discuss. Further, we extended the continuous functions to fuzzy multiset continuous function and also discussed subspace of fuzzy multiset topological space
Spiritual Well-being of Tribal Women Residing at Kottarankundru Village, Perambalur (DT)
Authors: Maheswari. K Tharani. V,
Published: July 2023

Spirituality is referred as a religious process of re-formation which aims to recover the original shape of man and oriented at “the image of God” as exemplified by the founders and sacred texts of the religions of the world. As other communities, the tribal communities also have some religious rules and regulations for their day to day life. The tribal community people believe the in truth of god and fear about gods‟ blessing and punishments. They are moreover suppressed with tribal culture. The spirituality is one of important part of their life, feel that there is meaning and purpose to their life; anywhere they believe in god and spiritual well-being. Hence, the present study has focused on spiritual well-being of tribal women. The main aim and objectives of the study is to inspect the socio-economic status and spiritual well-being among tribal women residing at Kottarankundru Village, Perambalur District. The researcher has adopted descriptive research design and has used simple random sampling method to select a sample of 54 respondents. Standardized tool on inner (spiritual) well-being developed by Yogesh Mohan was applied and interview schedule method was adopted to collect the data. The major findings of the study revealed that nearly majority of the respondents (57.4%) have low level of spiritual well-being
Some Operators on Interval Valued Intuitionistic Fuzzy Sets of Second Type
Authors: R. Srinivasan K. Rajesh
Published: July 2023

In this paper, we define some operators on Interval Valued Intuitionistic Fuzzy Sets of Second Type and establish some of their relations.
RMG Industry in Bangladesh: In search of Strategies for Creating and Sustaining Competitive Advantages Using Business Model Canvas
Authors: Jahan Sheikh Morshed , Rahman Gazi Mueedur , Islam Rummanun
Published: July 2023

Ready-made Garments (RMG) industry is one of the major drivers of the economy of Bangladesh as it accounts for more than 80% of the national export revenue of Bangladesh and employs about 5 million people, mostly women. This sector is becoming more exposed to the competition in global market, while it is haunted by tragedies such as Rana Plaza fire incidence. Most of the firms in this industry used to adopt cost-leadership strategy at the expense of good workplace practices and compliance. This approach no longer works because of the increased monitoring of international activists, suppliers, buyers, and the government of Bangladesh. To overcome this challenge, firms need to develop new strategies by redesigning their business model. Given the major competitive challenges that the industry is facing today, this study identifies some strategic imperatives for the firms to keep pace with the changing local and global dynamics involving the RMG industry
Psycholgical Therapies for Severe Mantal Health Problems. Training Delivery Evaluation
Authors:   Coventry University, Centre for Healthcare Research, Kneafsey Rosie , Pezaro Sally , Maravic de Silva Ksenija , Presley Vickie , Russell Sean , Bluteau Patricia , Bayes Natasha , Martin Faith
Published: July 2023

In Autumn 2021, Health Education England established a commissioned evaluation of the national provision of training for psychological therapies for severe mental health problems, known as the PTSMHP National Curriculum Delivery. A research team from Coventry University were commissioned to undertake this work, which has been undertaken with Coventry University research ethics approval (ref: P131322). This report sets out the methods, activities, findings and recommendations as requested by commissioners.
Evaluation of Pediatric Immune Thrombocytopenia (ITP) Cases and Risk Factors for Chronic ITP - Single Center Experience
Authors: ERDOĞAN Selçuk , KASAP Tuba , TAKÇI Şahin , GÜL Ali , SÖNMEZGÖZ Ergün , KARAASLAN Erhan , GÜMÜŞER Rüveyda , DEMİR Osman
Published: July 2023

Aim: Immune thrombocytopenia (ITP) is the most common acquired bleeding disorder in childhood. The study aimed to assess the demographic and clinical characteristics, and treatment responses and to evaluate their effects on chronicity in pediatric ITP cases.

Material and Methods: Primary ITP patients aged 1 month to 18 years, who were diagnosed and followed up in the Pediatrics Clinic of Tokat Gaziosmanpaşa University Hospital between January 2010 and December 2018, were retrospectively analyzed.

Results: Thirty-eight patients with a diagnosis of primary ITP were included in the study. The mean age of the patients was 94.3±53.4 (14-199) months. The female/male ratio was 1. Twenty (57.1%) patients had acute ITP, and 15 (42.9%) patients had chronic ITP. There was no significant difference between the acute ITP group and the chronic ITP group in demographic, clinical features, laboratory findings, and treatment responses. In the first 12 months, the number of admissions with a platelet count of
Seed Quality of Perennial Grasses and Forage Legumes in Relation to Dormancy, Storage, Presence of Pathogens and Possible Improvements
Authors: Stanisavljević Rade , Štrbanović Ratibor , Poštić Dobrivoj , Andjelković Snežana , Djokić Dragoslav , Milenković Jasmina
Published: July 2023

The manuscript presents the review of the impact of dormancy, seed storage, and pathogens on seed quality of perennial grasses and forage legumes. The outcomes of earlier studies to enhance the germination of seeds from these species are listed. Numerous studies around the world show that seed dormancy, environmental conditions, storage time after seed harvest, and the presence of pathogens on seeds, affecting the reduction of seed quality of these two groups of plants. This article discusses the possibility to partially or fully controlling impact of different factors on seed quality. Tests and experience of the presence of pathogens (especially Fusarium spp.) indicates a small percentage of infected seed of perennial grasses and legumes, which would not justify the cost of fungicides during seed processing. By applying the optimal concentration of acid in the seed, in combination with the time of exposure, it is possible to improve seed germination for more than 25% in forage grasses and legumes. Similar effects on the increase seed germination of both groups of plants can be achieving by optimal temperature treatments. Mechanical damage to the seed coat on the seeds of these crops can potentially increase germination, but new approaches are also being investigated.
A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle cell Anaemia
Authors: Aboderin Florence Ifechukwude , Oduola Taofeeq , Davison Glenda Mary , Oguntibeju Oluwafemi Omoniyi
Published: July 2023

Abstract
Sickle cell anaemia (SCD) is a life-threatening haematological disorder which is predominant in sub-Saharan Africa and is triggered by a genetic mutation of the β-chain haemoglobin gene resulting in the substitution of glutamic acid with valine. This mutation leads to the production of an abnormal haemoglobin molecule called haemoglobin S (HbS). When deoxygenated, haemoglobin S (HbS) polymerizes and results in a sickle-shaped red blood cell which is rigid and has a significantly shortened life span. Various reports have shown a strong link between oxidative stress, inflammation, the immune response, and the pathogenesis of sickle cell disease. The consequence of these processes lead to the development of vasculopathy (disease of the blood vessels) and several other complications. The role of the immune system, particularly the innate immune system, in the pathogenesis of SCD has become increasingly clear in recent years of research, However, little is known about the roles of the adaptive immune system in this disease. This review examines the interaction between the immune system, inflammation, oxidative stress, blood transfusion, and their effects on the pathogenesis of sickle cell anaemia
Drought Stress-Related Reprogramming of Gene Expression in Barley Leaves Involves Loading of ABA-Related Genes with Euchromatic Marks H3K4me3 and H3K9ac
Authors: Ost Charlotte , Cao Xuan Hieu , Nguyen Thuy Linh , Himmelbach Axel , Mascher Martin , Stein Nils , Humbeck Klaus
Published: July 2023

Plants respond to drought by major reprogramming of gene expression enabling the plant to survive this threatening environmental condition. One major upstream signal inducing this multifaceted process is the phytohormone abscisic acid (ABA). In this report, we investigate the drought response in barley plants (Hordeum vulgare, cv. Morex) at both epigenome and transcriptome levels. Leaves of barley plants after 10 days of drought treatment, when soil water content was decreased by about 40%, were compared to well-watered controls. Due to the drought treatment, chlorophyll content and photosystem II-efficiency were decreased by about 10% and some known drought-related genes were already induced. Global ChIPseq analyses were used to identify genes where histones 3 associated with promoter or gene body were modified with euchromatic K4 trimethylation or K9 acetylation during drought. Using stringent exclusion criteria, 129 genes loaded with H3K4me3 and 2008 genes loaded with H3K9ac in response to drought were identified, indicating that H3K9 acetylation reacts to drought more sensitive than H3K4 trimethylation. Comparison with differentially expressed genes enabled to identify those genes, which are loaded with the euchromatic marks and are induced in response to the drought treatment. The results show that a major part of these genes is involved in ABA-signaling and related pathways. Intriguingly, two members of the protein phosphatase 2C family (PP2Cs), which are involved in the central regulatory machinery of ABA signaling, were also identified by this approach.
Invariant Attribute-driven Binary Bi-branch Classification for Hyperspectral and LiDAR Images
Authors: Zhang Jiaqing , Lei Jie , Xie Weiying , Li Daixun
Published: July 2023

Hyperspectral image and LiDAR image fusion plays a crucial role in remote sensing by capturing spatial relationships and modeling semantic information for accurate classification and recognition. However, existing methods, like Graph Convolutional Networks (GCNs), face challenges in constructing effective graph structures due to variations in local semantic information and limited receptiveness to large-scale contextual structures. To overcome these limitations, we proposed a invariant attribute-driven binary bi-branch classification (IABC) method which is a unified network that combines binary Convolutional Neural Network (CNN) and GCN with invariant attributes. Our approach utilizes a joint detection framework that can simultaneously learn features from small-scale regular regions and large-scale irregular regions, resulting in an enhanced structured representation of HSI and LiDAR images in the spectral-spatial domain. This approach not only improves the accuracy of classification and recognition but also reduces storage requirements and enables real-time decision-making, which is crucial for effectively processing large-scale remote sensing data. Extensive experiments demonstrates the superior performance of our proposed method in hyperspectral image analysis tasks. The combination of CNNs and GCNs allows for accurate modeling of spatial relationships and effective construction of graph structures. Furthermore, the integration of binary quantization enhances computational efficiency, enabling real-time processing of large-scale data. Therefore, our approach presents a promising opportunity for advancing remote sensing applications using deep learning techniques.
The Yin and the Yang of Hemostasis in End-Stage-Liver-Disease
Authors: Saner Fuat H. , Scarlatescu Ecaterina , Broering Dieter , Bezinover Dmitri
Published: July 2023

Patients with end stage liver disease (ESLD) undergoing liver transplantation are prone to thromboses both while on the waiting list or in the perioperative period. This hypercoagulability is associated with significant endothelial dysfunction (ED) due to nitric oxide dysregulation. ED in combination with increased thrombin generation are the main factors responsible for this hypercoagulability. Sepsis itself can significantly change the coagulation profile, but in combination with ESLD, sepsis, and septic shock is responsible for very complex changes in the patients coagulation making both assessment and management of coagulation in patients with ESLD very challenging. Viscoelastic testing (VET) is a preferred method of coagulation management in patients with cirrhosis because, as with standard laboratory testing, VET can assess the entire coagulation system including the interaction between both pro- and anticoagulants and platelets.
Net Energy Gain from a Berry Geometrical Phase – Low-Energy Perturbations of the Strong Interaction and the QCD Mass Gap
Authors: Gibbons Mark
Published: July 2023

Berry curvature is deemed responsible for generating work in a strongly metastable system containing dynamically responsive clathrate hydrate structures. Hyperbolic curvature produces non-extensive volume changes and is attributed to gluon emission and reabsorption in a U(2) electroweak symmetry group synchronized across the condensed matter system, the embedding vacuum manifold and associated quantum interactions. The property of asymptotic freedom is evident across these three domains. Pressure perturbations of the low-energy system initiate ‘rolling’ critical responses that establish conservation of energy and momentum across the synchronized U(2) group and reveal an emergent gauge field. The corresponding emergence of a Ginzberg-Landau superconducting phase transition is consistent with gauge-invariant coupling of this scalar field to the Yang-Mills action of QCD. The discovery of an energy gap in the gradient energy term of the system Lagrangian is associated with a critical correlation length and is consistent with a complex energy band gap in the Berry phase. Coupled with the emergence and absorption of the Higgs-like scalar field, a mechanism for describing the QCD mass gap arises.
Brain-Derived Reconstituted Lipid Nanoparticles Show Selective Homing to Ischemic Brain
Authors: Han Dan , Wang Cheng
Published: July 2023

Lipid nanoparticles (LNPs) are promising carriers for constructing drug delivery systems (DDSs) in disease treatments. Previous studies have suggested that lipid composition and biophysical properties of LNPs can significantly impact their interaction with cells and tissues, allowing for the development of suitable LNPs for precise drug delivery. Our previous study proposed the concept and facile preparation of reconstituted lipid nanoparticles (rLNPs), which not only have the advantages of traditional LNPs but also contain the lipids of mother cell/tissue. In this study, we have found that brain-derived rLNPs (B-rLNPs) can have much better accumulation to the ischemic area of the ischemic stroke (IS) model than liver-derived rLNPs (L-rLNPs). This homing effect hopefully makes rLNPs a useful tool for developing highly accessible devices with homologous targeting ability for precise drug delivery.
PP-JPEG: A Privacy-Preserving JPEG Image Tampering Localization
Authors: Jena Riyanka , Singh Priyanka , Mohanty Manoranjan
Published: July 2023

The widespread availability of digital image processing softwares has given rise to various forms of image manipulation and forgery which can pose a significant challenge in different fields such as law enforcement, journalism etc,. it can also lead a privacy concern. We are proposing a privacy-preserving framework to encrypt images before processing them is vital to maintain the privacy and confidentiality of sensitive images, especially those used for purpose of Investigation. To address these challenges, we propose a novel solution that detects image forgeries while preserving the privacy of the images. Our method proposes a privacy-preserving framework that encrypts the images before processing them, making it difficult for unauthorized individuals to access them. The proposed method utilizes a compression quality analysis in the encrypted domain to detect the presence of forgeries in images if the forged portion (dummy image) has a compression quality different from the original image (featured image) in the encrypted domain. This approach effectively localizes the tampered portions of the image, even for small pixel blocks of size 10x10 in the encrypted domain. Furthermore, the method identifies the featured image's JPEG quality using the first minima in the energy graph.