bluuebunny/crossref_metadata_2025 huggingface dataset:
Net Economic Benefits from Shifting Consumption, Labor Elasticity, and Productivity Gains During an Accelerated Renewable Energy Transition in China
Authors: Chen Yidan , Lin Jiang , Roland-Holst David , Wang Can
Published: September 2020

China is the world’s largest greenhouse gas (GHG) emitter, but declining wind and solar energy costs present opportunities to transform its electric power sector. In 2017, China launched a national emission trading scheme (ETS). Evidence to date suggests that the ETS mitigates CO2 emissions and promotes renewable energy deployment but constrains economic growth. These studies, however, do not account comprehensively for economic impacts. Ours is the first to account for three multiplier effects—shifting consumption patterns, job growth with elastic labor supply, and higher total factor productivity (TFP)—when modeling accelerated renewable electricity growth with the ETS in China. Results from a detailed economic forecasting model show low renewable energy costs interacting with the ETS to slash GHG emissions while directly stimulating incremental net positive economic growth by 2030, compared with a business-as-usual scenario that assumes slower renewable cost reductions and no ETS. Accounting for the multiplier effects reveals larger potential benefits, including up to 15.6% of additional GDP growth (over business as usual) by 2030 when shifting consumption patterns, job growth with elastic labor supply, and higher TFP are all considered. These results suggest that China should accelerate its clean energy transition, not only for the air-quality and climate benefits, but also for the broad and positive impact on innovation, employment, and economic growth.
Guided Imagery for Treatment (GIFT): Protocol of a Pilot Trial of Guided Imagery Versus Treatment as Usual to Address Radiotherapy-related Distress in Head and Neck Cancer
Authors: Kolva Elissa , Karam Sana D , Carr Alaina , Roberts Sydneyjane , Torkko Kathleen , Lanning Ryan , Cox-Martin Emily
Published: September 2020

Background: Cancers of the head and neck region are associated with high symptom burden and elevated levels of psychological distress. Radiotherapy (RT) is a common treatment for patients with head and neck cancer (HNC) that is associated with psychological distress related to the immobilizing nature of the treatment, frequency of treatment delivery, and side effects. Guided imagery is a relaxation technique that is beneficial in reducing psychological distress in patients with other cancer diagnoses but has not been studied in this patient population. The purpose of this study is to evaluate the feasibility and acceptability of a brief guided imagery intervention (Guided Imagery for Treatment; GIFT) to reduce RT-related anxiety and depression in patients with HNC relative to treatment as usual (TAU).Methods: Patients with HNC planning to receive RT will be recruited to participate in a randomized controlled trial evaluating a brief, two-session guided imagery intervention (GIFT) relative to TAU alone. Primary aims include acceptability and feasibility evaluated through quantitative and qualitative methods. Measures of anxiety and depression, symptom burden, health-related quality of life, and anxiolytic medication use will be collected at baseline, during treatment, and at one-month follow-up. Discussion: There are no published interventions of guided imagery for anxiety and depression in patients with HNC despite its efficacy in other populations of patients with cancer. This proposed project evaluates the feasibility and acceptability of an intervention that has the potential to reduce psychological distress in a vulnerable population. Additionally, we will preliminarily examine the impact of behavioral intervention on psychological distress and the use of anxiolytic medication, a novel area of study. Trial registration: Clinicaltrials.gov NCT03662698;registered on 9/6/2018. https://clinicaltrials.gov/ct2/show/NCT03662698?term=guided+imagery&cond=Head+and+Neck+Cancer&rank=1
Effects of the Oocyte Maturation Rate on Clinical Outcomes of Conventional IVF and ICSI in Female Patients Aged ≥38 Years
Authors: liu shuang , Yu Hongjun , Li Baoshan , Li Chunyi , Cheng Dongkai
Published: September 2020

Research Question: The average female reproductive potential peaks at age 25 and then begins to decline. As women are delaying childbearing, the prevalence of infertility has risen, leading to increasing demand for assisted reproductive technology (ART). Oocyte quality remains the most important issue during in vitro fertilization (IVF) cycles. This study investigated the effects of the oocyte maturation rate (OMR) on clinical outcomes of conventional IVF and intracytoplasmic sperm injection (ICSI) in female patients aged ≥38 years. Design: A retrospective analysis of 6562 infertile patients who were treated with IVF/ICSI at the reproductive medicine center of our hospital from January 2011 to December 2017 was performed. According to the oocyte maturity (the ratio of the number of mature oocytes to the number of oocytes) on the day of egg collection, the patients were divided into three groups: group A (oocyte maturity ≤30%, n=422), and group B (oocyte maturity from 30-75%, n=1290), and group C (oocyte maturity ≥75%, n=4850). The patient age, years of infertility years, days of gonadotropin (Gn), Gn dosage, serum luteinizing hormone (LH), estradiol (E2), and progesterone (P) levels on the day of human chorionic Gn (HCG) injection, E2 levels per mature oocyte, E2 levels per oocyte, number of mature oocytes, oocyte recovery rate, fertilization rate, cleavage rate, excellent embryo rate, blastocyst formation rate, pregnancy rate, and live birth rate were compared among the three groups. Results: Factors including age, years of infertility, number of eggs obtained, number of mature eggs, normal fertilization rate, cleavage rate, excellent embryo rate, blastocyst formation rate, pregnancy rate, and live birth rate were all found to be related to oocyte maturity on the day of HCG administration (P<0.05). Conclusions: There is a close relationship between oocyte maturity and embryo quality, and a low OMR may be related to a poor ovarian response or decreased sensitivity to Gn. Therefore, a low OMR may affect the fertilization and embryonic development potential in elderly patients undergoing IVF/ICSI, thus affecting the pregnancy rate.
Hsa-miRNA-143-3p Regulates Differentiation of Human Stem Cells From The Apical Papilla Through Targeting Nuclear Factor I-C
Authors: Gao Shuo , Li Pei , Zhao Yuming , Li Yao-yin , Ge Li-Hong , Zhao Wei
Published: September 2020

Background : Dental root development is independent and time-space-specific. Nuclear factor I-C (NFIC) plays a key role in human root development through regulating the differentiation of stem cells from the apical papillary (SCAPs). The function of microRNAs during the differentiation of SCAP and post-transcriptional regulation of NFIC remain unclear. Methods : We examined the microRNA expression profiles in human immature permanent teeth and SCAPs differentiation. hSCAPs were treated with miR-143-3p over/low-expression viruses, and the odonto/osteogenic differentiation of these stem cells and the involvement of NFIC pathway were investigated. Next, luciferase reporter and its mutant plasmids were used to confirm direct target gene of miR-143-3p. Mineralization induction assays ex vivo and in vitro were used to investigate the functional significance of miR-143-3p. Results : MiR-143-3p was screened by microarray expression profiling and bioinformatics technology, which decreased during hSCAPs differentiation. Overexpression of miR-143-3p inhibited the odontogenic differentiation of hSCAPs and downregulated the related genes, whereas the functional inhibition of miR-143-3p yielded the opposite effect. The luciferase reporter gene detection and bioinformatics approach identified NFIC as a potential target of miR-143-3p. Furthermore, NFIC Overexpression reversed the inhibitory effect of miR-143-3p on the odontogenic differentiation of hSCAP. Conclusions : MiR-143-3p maintains the stemness of hSCAPs and negatively modulates their differentiation and mineralization by directly targeting transcription factor NFIC, which serves as an contribution towards a better understanding of the developmental mechanisms of root formation.
The Bacterial Communities of Alaskan Mosses and Their Contributions to N2-Fixation
Authors: Holland-Moritz Hannah , Stuart Julia E. M. , Lewis Lily R. , Miller Samantha N. , Mack Michelle C. , Ponciano Jose Miguel , McDaniel Stuart F. , Fierer Noah
Published: September 2020

Background: Mosses in high latitude ecosystems harbor diverse bacterial taxa, including N2-fixers which are key contributors to nitrogen dynamics in these systems. Yet, the relative importance of moss host species, and environmental factors, in structuring these microbial communities and their N2-fixing potential remains unclear. We studied 26 boreal and tundra moss species across 24 sites in Alaska, USA from 61º to 69º N. We used cultivation-independent approaches to characterize the variation in moss-associated bacterial communities as a function of host species identity and site characteristics. We also measured N2-fixation rates via 15N2 isotopic enrichment and identified potential N2-fixing bacteria using available literature and genomic information. Results: Host species identity and host evolutionary history were both highly predictive of moss microbiome composition, highlighting strong phylogenetic coherence in these microbial communities. Although less important, light availability and temperature also influenced composition of the moss microbiome. Finally, we identified putative N2-fixing bacteria specific to some moss hosts, including potential N2-fixing bacteria outside well-studied cyanobacterial clades. Conclusions: The strong effect of host identity on moss-associated bacterial communities demonstrates mosses’ utility for understanding plant-microbe interactions in non-leguminous systems. Our work also highlights the likely importance of novel bacterial taxa to N2-fixation in high-latitude ecosystems.
Antiretroviral Therapy–Related Experiences Predict Mental Health Status Among People Living with HIV in China: A Prospective Observational Cohort Study
Authors: Xie Jinzhao , Wang Zixin , Li Quanmin , He Qiangsheng , Xu Guohong , Li Yonghong , Zhou Kai , Li Linghua , Gu Jing
Published: September 2020

Background: Antiretroviral therapy (ART) coverage has increased sharply. This prospective observational cohort study investigated the association between experiences related to ART and mental health problems among a sample of people living with HIV in China.Methods: The participants were 400 people living with HIV who had started ART for the first time in Guangzhou city. They were followed-up one-year after ART initiation. Probable depression and moderate/severe anxiety were measured at baseline and Month 12, while experiences related to ART were measured at Month 6. Univariate and multivariate logistic regressions were used to explore the predictors of mental health status.Results: Among the 300 participants (75.0%) who completed all three surveys, a significant decline in prevalence of probable depression (23.0% at baseline vs. 14.0% at Month 12, P = 0.002) and moderate/severe anxiety (14.7% at baseline vs. 8.7% at Month 12, P = 0.023) was observed during the follow-up period. After adjustment for mental health status and potential confounders at baseline, a number of ART-related experiences at Month 6 were associated with probable depression and/or moderate/severe anxiety measured at Month 12. Improved physical health, relationships with sexual partners, and self-confidence were associated with decreased mental health issues, while the side effects of ART, AIDS-related symptoms, and inconvenience in daily life due to ART use were associated with increased mental health issues.Conclusions: ART-related experiences were predictors of mental health problems, tailored mental health promotion interventions targeting these experiences are needed.
Association Between Triglyceride Glucose Index and Risk of New-onset Diabetes Among Chinese Adults: Findings From the China Health and Retirement Longitudinal Study
Authors: Chen Chaolei , Liu Lin , LO Kenneth , HUANG Jiayi , Yu yuling , HUANG yuqing , Yingqing Feng
Published: September 2020

BackgroundThe triglyceride glucose (TyG) index has been proposed to be a simple surrogate of insulin resistance. We aimed to examine the relationship between TyG index and risk of incident diabetes in middle-age and elderly adults in China.MethodsNationally representative data from the China Health and Retirement Longitudinal Study 2011-2015 were used. Sociodemographic, medical, anthropometric, and laboratory information were collected following a standard protocol. Cox proportional hazards models and restricted cubic spline regression were performed to estimate hazard ratio (HR) with 95% confidence interval (CI) of diabetes for TyG index. Subgroup analyses were also conducted to examine potential interactions. ResultsOf 7428 participants without at baseline diabetes, 791 (10.6%) participants developed diabetes over 3.4 years of follow-up. The multivariate HR for every SD increase in TyG index was 1.22 (95% CI, 1.14-1.31). When dividing TyG index into quartiles, the multivariate HRs for new-onset diabetes were 1.22 (0.96-1.54) for Q2, 1.61 (1.28-2.01) for Q3, and 1.73 (1.38-2.16) for Q4 (P for trend < 0.001) compared with Q1. The restricted cubic spline regression confirmed a linear association. No interaction was found between subgroup variables and association of TyG index with risk of diabetes.ConclusionTyG index was significantly and positively associated with risk of new-onset diabetes in middle-aged and elderly adults. TyG index may be a useful predictive marker for predicting new-onset diabetes.
Validation of the Functions and Prognostic Values of Synapse Associated Proteins in Lower-Grade Glioma
Authors: Lin Han , Yang Yong , Hou Chongxian , Zheng Jiantao , Lv Guangzhao , Mao Rui , Xu Peihong , Chen Shanwei , Zhou Yujun , Wang Peng , Zhou Dong
Published: September 2020

BackgroundSynapse and synapse associated proteins (SAPs) play critical roles in various neurodegeneration diseases and brain tumors. However, in lower-grade gliomas (LGG), SAPs have not been explored systematically. Herein, we are going to explore SAPs expression profile and its clinicopathological significance in LGG which can offer new insights to glioma therapy. MethodIn this study, we used five sources including, Venkatesh, Shen, Colón, Jüttner R, Gene Ontology (GO) project to integrate a list of SAPs that covered 231 proteins with synaptogenesis activity and post synapse formation. The LGG RNA-seq data were downloaded from gene expression omnibus (GEO) database, The Cancer Genome Atlas (TCGA), and Chinese Glioma Genome Atlas (CGGA). The differentially expressed SAPs were filtered out and constructed PPI to search for key modules and SAPs. Then, using Kaplan–Meier survival analysis, least absolute shrinkage and selection operator (LASSO), and multicox regression analysis, the prognostic significance of these key SAPs was evaluated. CGGA database, Human Protein Altas (HPA) and quantitative real-time PCR were used to verify our findings. ResultData from function enrichment analysis revealed functions of differentially expressed SAPs in synapse organization and glutamatergic receptor pathway in LGGs. Survival analysis revealed four SAPs, GRIK2, GABRD, GRID2, ARC that were correlate with the prognosis of LGG patients and used to construct the prognostic models. Among them, the expression of GABRD was lower in glioma tissue than normal brain tissue, but higher in seizure LGG patients than non-seizure patients. The four-SAPs signature was revealed as an independent prognostic factor in gliomas. ConclusionOur study presented a novel strategy to assess the prognostic risks of LGGs, based on the expression of SAPs. Also, we revealed that several SAPs upregulated in patients with seizures, indicating that they are linked to the pathogenesis of seizures in glioma patients.
Evaluation of Intracranial Pressure by Ultrasound of the Optic Nerve Sheath in an Animal Model of Intracranial Hypertension
Authors: Jeng Brasil P , Andrade Almir F , Bor-Seng-Shu Edson , Belon Alessandro R , Robertis Maira , Oliveira Marcelo L , Rubiano Andres M , Godoy Daniel A , Teixeira Manoel J , Paiva Wellingson Silva
Published: September 2020

Background: Invasive monitoring of intracranial pressure is currently the only accepted method for the safe diagnosis and treatment of intracranial hypertension, but it is subject to hemorrhage, infection and malfunction. Ultrasound of the optic nerve sheath diameter is a non-invasive alternative that is cost effective and available at the bedside. The objective of this study was to correlate intracranial pressure and ultrasonography of the optic nerve sheath in an experimental animal model of cerebral hematoma. Materials and Methods: An experimental study was conducted on 30 male and female pigs wighing about 20 kg. The diameter of the optic nerve sheath was measured by ultrasound at different points of intracranial pressure. Intracranial pressure was simultaneously measured with an intraparenchymal catheter, and laboratory and hemodynamic data was collected from the animals. The values were correlated with each other to explore the application of this procedure in different clinical situations involving intracranial hypertension. Results: All the variables obtained by ONSD ultrasonography (Left Optic nerve LON, Rigth optic nerve RON and Avarage of Optic Nerve sheath AON) were statistically significant to predict the ICP value. AON presentation changes in relation to baseline from the moment of balloon inflation. AON proved to be the best parameter for predicting ICP and presented the best correlation. AON showed a delay of 30 minutes compared to ICP decrease, as it maintained values higher than baseline values at the ballon deflation moment (p = 0.016). Thus, intracranial pressure can be predicted using the linear function: -80.5 + 238.2 × the optic nerve sheath diameter. Conclusion: Optic nerve sheath diameter ultrasound is a reliable method for predicting intracranial pressure.
Increased Bone Formation and Bone Resorption in Patients with Hemophilic Arthropathy: A Cross-Sectional Study
Authors: Zhang Shengyang , He Bangjian , Xu Huihui , Shi Zhenyu , Tong Peijian , Mao Qiang
Published: September 2020

Background: Previous studies have revealed that hemophilia patients with severe osteoporosis have more arthropathy symptoms and that their bone metabolism is frequently abnormal. However, it is unclear how to achieve an early diagnosis of hemophilic arthropathy (HA) through abnormalities in bone metabolism.Methods: This study includes 46 patients with HA, 48 healthy controls (HC) and 43 hemophilia without arthropathy (HWA) patients (5 patients were excluded). We measured and compared bone turnover markers (BTMs) including osteocalcin (OC), n-terminal procollagen 1 elongating pro-peptide (t-P1NP) and β-isomerized collagen I-c-terminal peptide breakdown product (β-CTx) of three groups. Receiver operating characteristic (ROC) curve was drawn to obtain the critical value of BTMs for the diagnosis of HA. One-way ANOVA was used to compare the BTMs levels in different degrees of hemophilia. Multivariate linear regression was performed to analyze the correlation between BTMs and clinical severity of HA. Results: The t-P1NP, β-CTx and OC levels of HA and HWA patients were higher than HC, and HA patients had higher t-P1NP and β-CTx levels than HWA patients (p<0.001). But there was no significant difference in OC levels between HA and HWA groups. Logistic regression analysis revealed that high β-CTx and high t-P1NP were significantly associated with HA. ROC curve showed the highest area under the curve was the t-P1NP+β-CTx model (area under the curve was 0.686, the sensitivity was 54.5% and the specificity was 82.5%, the cut-off value was 0.578). Multivariate linear regression analysis indicated that β-CTx was positively correlated with the clinical severity of HA, and t-P1NP levels was negatively correlated with the clinical severity of HA. β-CTx levels decreased with the degree of hemophilia. Conclusions: Increased bone resorption and bone formation were associated with the onset of HA, and the t-P1NP+β-CTx model (β-CTx >775.200 ng/mL and t-P1NP>55.100 ng/mL) contributed to the diagnosis of HA.
Perfusion Technique in Total Arch Replacement to Prevent Cerebral Stroke in Patients Over 75 Years Old a Single Center Retrospective Cohort Study
Authors: kasama keiichiro , Uchida Keiji , Goda Motohiko , Suzuki Shinishi , Imoto Kiyotaka , Takebayashi Shigeo , Misumi Toshihiro , Masuda Munetaka
Published: September 2020

BackgroundTo evaluate the efficacy of isolated cerebral perfusion (ICP) for the prevention of cerebral infarction and the occurrence of early mortality, we retrospectively compared the outcomes between old patients with or without ICP in total arch replacement (TAR)MethodsBetween January 2003 and March 2019, 74 patients aged older than 75 years underwent elective TAR for arch aneurysm. The participants were divided into two groups according to the brain protection method used: the ICP method (ICP group, n = 46) and the selective antegrade cerebral perfusion method (non-ICP group, n = 28). ResultsThe 30-day mortality rates of both groups were zero. The in-hospital mortality rates of the ICP and non-ICP groups were 4.3% and 3.5%, respectively. The median follow-up duration was 34 months, and the 1-year survival rates were 90.1% in the ICP group and 90.7% in the non-ICP group. The incidence of postoperative cerebral infarction was significantly lower in the ICP group (n = 1, 2.1%) than in the non-ICP group (n = 5, 17.8%).ConclusionsICP could result in a lower incidence of postoperative cerebral infarction in old patients who undergo TAR.
The Effects of Chronic Branched-Chain Amino Acid Supplementation on Running Kinematics: Single Case Research
Authors: Whiton Tara K. , Sato Kimitake , Bazyler Caleb , DeWeese Brad , Stone Michael H
Published: September 2020

Purpose: To monitor the effects of chronic branched-chain amino acid (BCAA) supplementation on running kinematics in a trained ultra-endurance runner. Methods: One well-trained ultra-endurance runner followed three 10-day cycles of an AB design consuming a BCAA drink (SUP) or placebo (PLA) surrounding daily key workouts leading up to a 50-mile race (dosage = 0.08g/kg/day = 3.52g BCAA/day and 10.32g AA/day). During each 10-day cycle, the athlete completed a 5km run on an outdoor track at 6:30min/mile pace. A 10-meter capture zone was measured and marked with two orange cones for video recording and analysis. Kinovea open-source software (Version 0.8.15) was used to measure running kinematic variables: ground contact time (GCT), flight time (FT), and vertical oscillation (VO). Results: Vertical oscillation (VO) during a constant-pace run was significantly reduced from 88mm to 76mm when athlete was on SUP vs PLA condition (p = 0.00, Tau-U = 0.40). Statistical significance was not achieved for differences in GCT and FT between SUP and PLA (p = 0.06, Tau-U = 0.-17 and p = 0.28, Tau-U = 0.10 for GCT and FT, respectively). Weighted Tau-U results suggest that the BCAA supplement was overall 11% effective in improving combined measures of running kinematics (p = 0.04, Tau-U = 0.11). Discussion: A decrease in VO can indicate less overall muscle support requirements during stance phase and a reduced aerobic demand for a given task. We observed decreased VO during the 5km running tests on SUP indicating a reduction in wasteful vertical motion. Possible explanations for this could relate to improvement in muscle recovery characteristics from increased availability of BCAAs resulting in less chronic fatigue. Less fatigue can allow greater coactivation between two-joint muscles of the leg during stance resulting in more efficient joint rotations that are transferred into desired external forces, promoting more efficient movement and a more economical runner.
Comparison of the efficiency, safety and survival outcomes in two stem cells mobilization regimens with cyclophosphamide plus G-CSF or G-CSF alone in multiple myeloma: a meta-analysis
Authors: Wang Liwen , Xiang Hongxian , Yan Yuhan , Deng Zuqun , Li Hui , Li Xin , Liu Jing
Published: September 2020

Background Autologous stem cell transplantation as a frontline treatment for patients with multiple myeloma (MM), it requires an adequate peripheral blood stem cells (PBSC) collection before processing. Granulocyte-colony stimulating factor (G-CSF) with or without cyclophosphamide (CTX) are common regimens for PBSC mobilization, their benefits and risks are controversial. Methods To compare the efficiency, safety, and survival outcomes between the two regimens, we conducted a meta-analysis including 18 studies with 4 prospective and 14 retrospective studies, a total of 2770 patients with MM analyzed. Results The CTX plus G-CSF regimen had higher yields of total CD34+ cells (SMD = 0.39, 95% CI (0.30, 0.49)), and higher mobilization rates of the target ⩾ 2x106/kg (OR = 3.34, 95% CI (1.82, 6.11)) and 4x106/kg (OR = 2.16, 95% CI (1.69, 2.76)) cells. A favorable EFS (HR = 0.73, 95% CI (0.58, 0.93), p = 0.01) and better 3-year EFS rate (OR = 1.65, 95% CI (1.1, 2.47), p = 0.02) were also reached in the patients with CTX plus G-CSF mobilization, although the risks of admission (OR = 26.49, 95% CI (7.31, 95.97)) and fever (OR = 13.66, 95% CI (6.21, 30.03)) during mobilization were increased, the treatment-related mortality were consistent (p = 0.26). Conclusions The CTX plus G-CSF regimen was superior to the G-CSF-alone regimen for PBSC mobilization in patients with MM.
Ultra-early indicators of acute hypertriglyceridemic pancreatitis may affect treatment decision-making
Authors: Wu Jing , Tang Xiaoting , Li Chaowei , Rao Zilan , Liang Yizhi , Pan Xiaoping , Fang Taiyong
Published: September 2020

Background: The present study aimed to investigate whether the ultra-early indicators can predict severity of acute hypertriglyceridemic pancreatitis (HTGP) and affect clinical decisions. Methods: We performed an observational retrospective study with data from 110 enrolled patients with HTGP from January 2017 to February 2020. According to the final clinical outcome, HTGP patients were divided into MAP group and MSAP-SAP group. Demographic and clinical data were collected, and ultra-early indicators (serum calcium, TG, IL-6, D-dimer, HbAc1, arterial lactate) levels were measured within 6 h of admission. A multivariate logistic regression analysis model and receiver operating characteristic curve were adopted to evaluate the value of ultra-early indicators for identifying high-risk patients. The chi-square test method was used to estimate the time of hospitalization and complications in MSAP-SAP group after plasma exchange within or more than 24 hours. Results: Of the 110 HTGP patients, a total of 56 patients with mild AP and 54 MSAP-SAP HTGP patients included. TG, IL-6, D-dimer, HbAc1, and arterial lactate levels which measured within 6 h after admission were significantly higher in the MSAP-SAP group, but serum calcium was significantly lower, versus the mild AP group. IL-6, D-dimer, and serum calcium were found to be risk factors for MSAP-SAP and could ultra-early predict HTGP severity, particularly within 6 hours of admission. We found that patients of MSAP-SAP treated with Blood purification within 24 hours of admission have shorter hospital stay time than over 24 hours of admission. Conclusion: Ultra-early indicators of IL-6, D-dimer, and serum calcium may be useful biomarkers for assessing AP severity in HTGP patients within 6 hours. Early blood purification therapy should be taken for MSAP-SAP patients within 24 hours, because fewer patients could suffer from complications and more patients had shorter hospital stay time. While traditional treatment could be implemented for MAP patients to reduce medical expenses and still obtain good therapeutic effect. Keywords: Hypertriglyceridemic pancreatitis, Ultra-early indicators, Clinical decisions, Therapeutic effect
Circulating long non-coding RNAs as potential biomarkers for stomach cancer: A systematic review and meta-analysis
Authors: Cao Fang , Hu Yongwei , Chen Zaichang , Han Wei , Lu Weijie , Xu Jianhao , Ding Houzhong , Shen Xiaojun
Published: September 2020

Background: Recent researches have suggested that long non-coding RNA (lncRNA) is involved in the tumorigenesis and development of stomach cancer (SC). This meta-analysis aimed to identify the diagnostic performance of circulating lncRNAs in SC.Methods: All relevant studies were systematically searched through PubMed, Web of Science, Cochrane Library and EMBASE databases. The diagnostic values of lncRNAs were mainly assessed by pooled sensitivity (SEN), specificity (SPE), and summary receiver operating characteristic area under the curve (SROC AUC). Meta-DiSc 1.4, Review Manager 5.3 and STATA 12.0 were used for statistical analysis. Results: A total of 42 eligible studies were included in this meta-analysis. The pooled SEN, SPE, and AUC were 0.78 (95%CI: 0.75-0.81), 0.75 (95%CI: 0.71-0.78), and 0.83 (95%CI: 0.80-0.86) respectively, suggesting that the lncRNAs test had a high accuracy for the diagnosis of SC. Obvious heterogeneity might come from the type of lncRNA through subgroup and meta-regression analysis. Fagan diagram showed the clinical value of lncRNAs test in SC. Conclusions: Abnormal expression of circulating lncRNAs exhibits a high efficacy for diagnosing SC, which is promising in clinical application.
The Effectiveness Of Application Of The Leadership Style And Entrepreneurial Orientation To Improve Business Performance
Authors: Siregar Budi Alamsyah
Published: September 2020

An owner's leadership style determines how the company carries out the activities in achieving its performance. The entrepreneurial orientation behavior present in an owner also determines how higher business performance can improve success. This study aims to understand how the role of a manager's leadership style and entrepreneurial orientation in improving his business performance. This research used a qualitative Delphi method by collecting in-depth data from 20 company owner. The results indicate the owner's transformational leadership style, a group of medium-sized enterprises that have developed and are beginning to be established, directly determines the applied entrepreneurial orientation. Finally, the application can affect the performance of the business. Behavior entrepreneurial orientation; not only promotes business growth medium, but it can also affect large enterprises' profitability due to the indirect impact achieved by large companies through cooperation in the supply of raw materials for products. The impact of increasing innovation power, proactive power, and risk-taking power on business performance arise from the support of a transformational leadership style. When transformational leadership styles and entrepreneurial orientations combine, medium-sized enterprises will achieve higher performance.
HASSAN HANAFI’S OCCIDENTALISM
Authors: Al-Hamdi Ridho
Published: September 2020

This paper examines Hanafi’s concept of Occidentalism in the epistemological approach. It aims to investigate the character, study source, research method, validity, and objectives of Occidentalism. The paper findings demonstrate that Occidentalism is a science which aims to dismantle the myth of Western superiority and, in turn, to build an equal civilization. The study root of Occidentalism is the formation, structure, and fate of the European consciousness. The formation comprises the exposed and unexposed sources of the European consciousness. The structure encompasses the ideologies of nationalism, Zionism, Nazism, Facism, and racialism. Fate relies on the model of the relationship between the East and the West. Afterward, Hanafi employs two research methods: historical-dialectical and phenomenology. Lastly, science can be recognized as Occidentalism if it has a fivefold standard: there is the dialectic of the East and the West, positioning European consciousness as the study object, self-liberation as the spirit to liberate the East from Western hegemony, dismantling the myth of cosmopolite culture, and the accomplishment of an equal civilization.
THE SOCIOPOLITICAL ENTANGLEMENT OF SUFISM
Authors: Al Abza M Thohar , Kamsi Kamsi Kamsi , Ismail Nawari
Published: September 2020

Sufi group (tarekat) mainly dictates its followers to distance themselves from worldy affairs and to live in religious seclusion (zuhud). This article offers a distinct perspective on the study of sufism through examining the political activities of the sufi group the Tarekat Qa>diriyah wa Naqsyabandiyah of Cukir in Indonesia and the group’s political patron, the Partai Persatuan Pembangunan (PPP). The article benefits form a French philosopher Michel Foucault’s concept of geneology and the notion of knowledge to better comprehend the nature of political activism of a sufi group. It further argues that basic concept of student and master (murshid) relationship in Sufism is explaining the politics of sufism in contemporary Indonesia. The mutual relation between leaders of the sufi group and the PPP has facilitated the crossing boundaries of Sufi basic principle of non-participatory politics.
THE QUR’ANIC JESUS
Authors: Ghafur Waryono Abdul , Prasojo Zaenuddin Hudi , Bin Haji Masri Mohammed Sahrin
Published: September 2020

This article examines the theological polemics between Islam and Christianity focusing on the prophetic attribution of Isa al-Masih in Islamic tradition. It takes a close look at the Qur’anic construction upon the Prophet Isa al-Masih as a human being who served as a messenger of God, while briefly comparing the Islamic construction to the Christian tradition projecting Isa-al-Masih as the son of God. Rather than emphasising differences between the two traditions, this article, through the Quranic concept kalimatun sawa’ (the shared principle or meeting point), sheds a new light on a shared belief between Islam and Christian traditions. Both Islam and Christianity believe that Isa al-Masih is the saviour for humanity, the liberator for the weak and the oppressed. The Qur’an maintains Isa al-Masih as one of the ulul azmi meaning that the prophets who successfully liberated his people.
Fotogafias, prova e contexto
Authors: Guerra Claudia Bucceroni , André Marques Junior Jairo
Published: September 2020

Este artigo tem como objetivo refletir sobre as fotografias dos campos de concentração e sobre as possibilidades de re-utilização dessas imagens em novos contextos que possibilitem restituir seu valor histórico e informativo. A representação visual do que ocorria nos campos de concentração é majoritariamente composta de fotografias que foram tiradas quando os soldados aliados invadiram os campos e libertaram os poucos prisioneiros que sobreviveram às atrocidades que ali ocorreram. Passados mais de setenta anos, de tão divulgadas em sites de diversos assuntos e redes sociais e arquivadas sem critérios de descrição corretos, percebe-se o problema da descontextualização, dos equívocos e do apagamento de importantes informações de muitas dessas fotos.
Gestão da Informação no sistema de Processo Judicial Eletrônico em um Tribunal Regional do Trabalho
Authors: Diniz Bárbara Carvalho , Silva Alzira Karla Araújo da
Published: September 2020

Reconhecendo a importância de a informação ser um elemento basilar para o poder judiciário, analisa a gestão da informação no Sistema de Processo Judicial Eletrônico (PJe) do Tribunal Regional do Trabalho (TRT) da 13ª Região. Caracteriza-se como pesquisa exploratória-descritiva, do tipo documental e de campo, com abordagem qualiquantitativa. Os dados foram coletados por meio de entrevista semiestruturada e observação sistemática, analisadas a luz da técnica de análise do discurso do sujeito coletivo. Os resultados refletem que o sistema gera agilidade, acessibilidade e melhora no fluxo processual. No entanto, apesar de o sistema gerenciar processos judiciais, considerado documentos arquivísticos, apresenta ausência dos princípios e critérios arquivísticos que podem prejudicar a gestão e o fluxo da informação do sistema. Conclui-se que, embora o sistema PJe traga vantagens, a ausência do cumprimento de requisitos da gestão de informação e da gestão de documentos poderá, futuramente, ocasionar problemas no acesso, uso e preservação das informações.
Criação de conhecimento na liderança e desenvolvimento de novos líderes
Authors: Biegelmeyer Uiliam Hahn , Vacari Gissele , Bernardi Flavia Camargo , Camargo Maria Emilia , Craco Tania
Published: September 2020

A liderança deve comunicar, motivar, delegar e planejar ações para que seus liderados apresentem comprometimento e demonstrem empenho em alcançar os objetivos propostos nesse sentido, o objetivo deste estudo foi identificar a percepção dos principais gestores da empresa, sobre a liderança e a importância da comunicação para atingir os resultados organizacionais, bem como identificar as possibilidades de aprimoramento e melhorias. Para tanto, a metodologia de pesquisa aplicada foi de caráter exploratório e abordagem qualitativa, por meio de um roteiro semiestruturado e entrevistas em profundidade conduzidas junto a seis gerentes. Os resultados da pesquisa evidenciam a necessidade de a empresa investir no desenvolvimento de líderes para aprimorar a comunicação interna e o processo de feedback, que foram citados pelos gestores como principais pontos de melhoria. Além disso, os resultados apontam para o desenvolvimento dos atuais e futuros líderes que atuam na organização.
Evidenciação do capital intelectual no Relato Integrado de empresas brasileiras participantes de programa piloto internacional
Authors: Ferreira Alves Nadson Jaime , Athayde Márcia , Nascimento Ivan Carneiro do , Croelhas Leandro Galvão
Published: September 2020

Diante da crescente exigência por uso responsável dos recursos, a comunicação corporativa, por meio do Relato Integrado (RI), avança na busca da efetividade da informação, integrando diferentes conteúdos para evidenciar como a organização cria valor, em linguagem clara, enxuta e útil aos usuários. Desta forma, esta pesquisa objetiva analisar como o capital intelectual (CI) está sendo evidenciado no RI de empresas brasileiras participantes do programa piloto do International Integrated Reporting Council (IIRC), sob os princípios da conectividade, completude, concisão e coerência. Metodologicamente, é uma pesquisa qualitativa, realizada por meio de análise de conteúdo de informações coletadas em 21 Relatos Integrados de sete empresas brasileiras, no período de 2016 a 2018. Os resultados evidenciaram conectividade de informações do próprio relato em todas as empresas, mas falham na conexão aos relatórios específicos (Financeiro, Sustentabilidade, Governança Corporativa e da Administração); no quesito completude, os relatos se apresentam completos, com exceções em valores monetários distintos quanto a cada tipo de investimento; no quesito concisão, há divergências na representatividade do capital intelectual em relação ao total de informações divulgadas; em relação à coerência, todos apresentaram coerência das informações divulgadas em relação a anos anteriores, mas, apenas duas empresas projetam o capital intelectual no futuro. Conclui-se, que todos os relatos cumpriram os requisitos básicos de evidenciação esperados, e descrevem o capital intelectual de forma menos quantitativa (monetária) e mais qualitativa, ainda que alguns sejam mais dispersos que outros, necessitando maior interação com outros relatórios da organização, além da necessidade de evidenciar os planos futuros de gestão do capital intelectual.
Competências e habilidades da indústria 4.0 no contexto dos cursos de Administração e Comércio Exterior
Authors: Zilli Julio Cesar , Silvério Leopoldo André Luís , De Sá Freire Patrícia , Carvalho Pinto Vieira Adriana , Boiani Estela
Published: September 2020

Este estudo objetivou identificar a percepção dos acadêmicos dos cursos de Administração e Comércio Exterior da Unesc, diante das suas competências e habilidades frente àquelas requeridas pela Indústria 4.0. Caracterizou-se como uma pesquisa quantitativa, descritiva, de cunho bibliográfico e de campo. A população foi composta por 203 acadêmicos, com a participação efetiva de 80 que responderam um questionário. Optou-se pela frequência simples com vínculo a literatura. Os acadêmicos concordam com o fato de que a quarta revolução criará uma produção mais precisa e personalizável, e também uma nova demanda de profissionais, mas discordam do fato de que os modelos atuais de educação e capacitação precisam de atualização. Os impactos na profissão do Administrador são conhecidos pelos acadêmicos, e os mesmos sabem quais profissões serão as mais afetadas. Por fim, percebe-se que os acadêmicos possuem em parte nos seus perfis, as competências e habilidades necessárias à Indústria 4.0.
Preface
Authors: Lima Clóvis Ricardo Montenegro de
Published: September 2020

Preface.
Nanomedicine and Early Cancer Diagnosis: Molecular Imaging using Fluorescence Nanoparticles
Authors: Jin Ke-Tao , Yao Jia-Yu , Ying Xiao-Jiang , Lin Yan , Chen Yun-Fang
Published: September 2020

Incorporating nanotechnology into fluorescent imaging and magnetic resonance imaging
(MRI) has shown promising potential for accurate diagnosis of cancer at an earlier stage than the conventional
imaging modalities. Molecular imaging (MI) aims to quantitatively characterize, visualize, and
measure the biological processes or living cells at molecular and genetic levels. MI modalities have been
exploited in different applications including noninvasive determination and visualization of diseased
tissues, cell trafficking visualization, early detection, treatment response monitoring, and in vivo visualization
of living cells. High-affinity molecular probe and imaging modality to detect the probe are the
two main requirements of MI. Recent advances in nanotechnology and allied modalities have facilitated
the use of nanoparticles (NPs) as MI probes. Within the extensive group of NPs, fluorescent NPs play a
prominent role in optical molecular imaging. The fluorescent NPs used in molecular and cellular imaging
can be categorized into three main groups including quantum dots (QDs), upconversion, and dyedoped
NPs. Fluorescent NPs have great potential in targeted theranostics including cancer imaging, immunoassay-
based cells, proteins and bacteria detections, imaging-guided surgery, and therapy. Fluorescent
NPs have shown promising potentials for drug and gene delivery, detection of the chromosomal
abnormalities, labeling of DNA, and visualizing DNA replication dynamics. Multifunctional NPs have
been successfully used in a single theranostic modality integrating diagnosis and therapy. The unique
characteristics of multifunctional NPs make them potential theranostic agents that can be utilized concurrently
for diagnosis and therapy. This review provides the state of the art of the applications of
nanotechnologies in early cancer diagnosis focusing on fluorescent NPs, their synthesis methods, and
perspectives in clinical theranostics.
Hyaluronan-based Multifunctional Nano-carriers for Combination Cancer Therapy
Authors: Gao Menghan , Deng Hong , Zhang Weiqi
Published: September 2020

Hyaluronan (HA) is a natural linear polysaccharide that has excellent hydrophilicity, biocompatibility,
biodegradability, and low immunogenicity, making it one of the most attractive biopolymers
used for biomedical researches and applications. Due to the multiple functional sites on HA and its intrinsic
affinity for CD44, a receptor highly expressed on various cancer cells, HA has been widely engineered
to construct different drug-loading nanoparticles (NPs) for CD44-targeted anti-tumor therapy.
When a cocktail of drugs is co-loaded in HA NP, a multifunctional nano-carriers could be obtained,
which features as a highly effective and self-targeting strategy to combat cancers with CD44 overexpression.
The HA-based multidrug nano-carriers can be a combination of different drugs, various therapeutic
modalities, or the integration of therapy and diagnostics (theranostics). Up to now, there are many
types of HA-based multidrug nano-carriers constructed by different formulation strategies, including
drug co-conjugates, micelles, nano-gels and hybrid NP of HA and so on. This multidrug nano-carrier
takes the full advantages of HA as an NP matrix, drug carriers and targeting ligand, representing a simplified
and biocompatible platform to realize the targeted and synergistic combination therapy against
the cancers. In this review, recent progress of HA-based multidrug nano-carriers for combination cancer
therapy is summarized and the potential challenges for translational applications have been discussed.
Stereospecific Synthesis of (4E,10Z)- 4,10-Tetradecadienyl Acetate, the Major Sex Pheromone of Apple Leaf Miner Moth, Phyllonorycter ringoniella
Authors: Awalekar Ramchandra , Jagadhane Kishor , Usmani Shams , Salunkhe Shilpa , Jamale Dattatray , Hangirgekar Shankar , Kolekar Govind , Anbhule Prashant
Published: September 2020

:

The main component of the sex pheromone of many lepidopteran pests, (4E,10Z)-4,10-tetradecadienyl acetate
(1) has been synthesized stereoselectively by using a simple route with 4-pentynol as a starting material. The stereoselective
formation of the 4E double bond is based on the stereospecific reduction of internal alkyne with lithium aluminium hydride
(LAH) while Wittig reaction was used to achieve 10Z double bond in the target pheromone component. The GC purity of
the final acetate was achieved 97.87% while isomeric purities are more than 99%. The green chemistry principle shows a
new concept towards for the multistep pheromone synthesis via green metrics calculations.
An Efficient Rapid Synthesis of Benzoxazoles and Benzothiazoles Using PMA.SiO2 at Room Temperature under Heterogeneous Conditions
Authors: Sudhakar Chithaluri , Shekar Vanam , Shyamsunder Manchi , Suryakumari Adurthi , Manojkumar Vala
Published: September 2020

:

Treatment of 2-aminophenol (or 2-aminothiophenol) with aromatic aldehydes in the presence of phosphomolybdic acid on silica at room temperature affords the corresponding benzoxazoles (or benzothiazoles) in excellent yields (88-
96%) under heterogeneous conditions. Benzoxazoles and benzothiazoles are formed less than 10 min.
Investigation and Analytical Applications of the Reaction of N1-methylnicotinamide and Active Methylene Containing Drugs
Authors: Elsebaie Heba A. , Elhamamsy Mervat H. , Elokely Khaled M. , Eldawy Mohammed A.
Published: September 2020

Background:

The reaction between N1-methylnicotinamide iodide (NMNI) and the active
methylene group-containing compounds yields a fluorescent product, which can be used in the
quantitative determination of certain drugs.

Objective:

The objective is to develop, adapt, and validate a simple spectrofluorometric method for
the quantitative analysis of modafinil 1, budesonide 2, allicin 3, and florfenicol 4.

Methods:

Spectral analysis (elemental analysis, 1H, 13C NMR, MS), computational methods (geometry
optimization, Gibbs free energy and pKa calculations) and spectrofluorometric approaches
were conducted.

Results:

A C4 cyclization pathway was confirmed for the formation of the fluorophore. The spectrofluorometric method showed good linearity (R2= 0.996-0.999) over concentrations of 1-50 ng/mL, 0.5-5 ng/mL, 60-150 pg/mL, and 1-15 ng/mL of the standard solutions of 1, 2, 3, and 4, respectively.

Conclusion:

The proposed method is simple and suitable for quality control and assurance studies