bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of Robot-Assisted Laparoscopic Partial Nephrectomy with Laparoscopic Cryoablation in the Treatment of Localised Renal Tumours: A Propensity Score-Matched Comparison of Long-Term Outcomes
Authors: Liu Hui-Ying , Kang Chih-Hsiung , Wang Hung-Jen , Chen Chien-Hsu , Luo Hao-Lun , Chen Yen-Ta , Cheng Yuan-Tso , Chiang Po-Hui
Published: April 2021

Preserving renal function and controlling oncological outcomes are pertinent when managing renal neoplasms. Cryoablation is the recommended treatment only for clinical T1a stage renal tumour. Here, we compared the outcomes of robot-assisted laparoscopic partial nephrectomy (RaPN) and laparoscopic cryoablation (LCA) in the treatment of patients with localised T1-T2 renal tumours. Overall, 86 patients who received RaPN and 78 patients underwent LCA were included in this study. The intraoperative, postoperative, and oncological outcomes in the LCA group were non-inferior to the RaPN group. Moreover, LCA demonstrated shorter operative time (267.45 ± 104.53 min vs. 138.56 ± 45.28 min, p < 0.001), lower blood loss (300.56 ± 360.73 mL vs. 30.73 ± 50.31 mL, p < 0.001), and slight renal function deterioration because of the reduced invasiveness, without compromising on the oncological outcomes.
Statistical Analysis of the Effectiveness of Wearable Robot
Authors: Lee Giwhyun , Cha Dowan
Published: April 2021

In this paper, we present a new statistical approach for evaluating the time-dependent effectiveness of wearable robots without real work. In total, 10 subjects participated in three phases of the experiment; not equipped with a wearable robot without any load, not equipped with the wearable robot with a 15 kg load, equipped with the wearable robot with a 15 kg load. A higher limb wearable robot called LEXO-W was utilized. We measured the time taken to complete a 10 m round trip 10 times as a lap time, and each participant was measured multiple times under all conditions. An increasing number of round trips causes an increment in lap times. In particular, the load-carrying group showed a rapid upward trend in lap time over the number of round trips. However, the robot-assisted group showed a slightly upward trend of lap time over the number of round trips. This study statistically shows that the LEXO-W helps reduce physical fatigue by using repeated measure ANOVA analysis. Furthermore, we employed the generalized additive model(GAM) model to predict and evaluate the effectiveness of the wearable robot.
Antenna Array with TEM-Horn for Radiation of High-Power Ultra Short Electromagnetic Pulses
Authors: Fedorov Vladimir M. , Efanov Mikhail V. , Ostashev Vasiliy Ye. , Tarakanov Vladimir P. , Ul’yanov Aleksander V.
Published: April 2021

An antenna array with short shielded transverse electromagnetic horns (S-TEM-horns) for emitting high-power radiation of ultra-short electromagnetic pulses (USEMP) has been created and researched. The antenna unit consists of an ultra-wideband antenna array with four S-TEM horns, with each connected to a two-wire HF transmission line, and these four lines are connected to an antenna feeder. This feeder is connected to a semiconductor generator with the following parameters: a 50 Ohm connector, 10–100 kV high-voltage monopolar pulses, a rise time of about 0.1 ns, FWHM = 0.2–1 ns, and pulse repetition rates of 1–100 kHz. The antenna array was designed and optimized to achieve a high efficiency of about 100% for the antenna aperture by using a 2 × 2 array with S-TEM-horns, with shielding rectangular plates for the return current. The transient responses were studied by simulation using the electromagnetic 3D code “KARAT” at the time domain and experimentally with the use of our stripline sensor for measurement of the impulse electrical field with a 0.03 ns rise time and a 7 ns duration at the traveling wave. The radiators were emitting USEMP waves with a hyperband frequency spectrum of 0.1–6 GHz. The radiation with an amplitude of 5–30 kV/m of the E-field strength at a distance of up to 20 m was successfully applied to test the electronics for immunity to electromagnetic interference.
Machine Learning in Wireless Sensor Networks for Smart Cities: A Survey
Authors: Sharma Himanshu , Haque Ahteshamul , Blaabjerg Frede
Published: April 2021

Artificial intelligence (AI) and machine learning (ML) techniques have huge potential to efficiently manage the automated operation of the internet of things (IoT) nodes deployed in smart cities. In smart cities, the major IoT applications are smart traffic monitoring, smart waste management, smart buildings and patient healthcare monitoring. The small size IoT nodes based on low power Bluetooth (IEEE 802.15.1) standard and wireless sensor networks (WSN) (IEEE 802.15.4) standard are generally used for transmission of data to a remote location using gateways. The WSN based IoT (WSN-IoT) design problems include network coverage and connectivity issues, energy consumption, bandwidth requirement, network lifetime maximization, communication protocols and state of the art infrastructure. In this paper, the authors propose machine learning methods as an optimization tool for regular WSN-IoT nodes deployed in smart city applications. As per the author’s knowledge, this is the first in-depth literature survey of all ML techniques in the field of low power consumption WSN-IoT for smart cities. The results of this unique survey article show that the supervised learning algorithms have been most widely used (61%) as compared to reinforcement learning (27%) and unsupervised learning (12%) for smart city applications.
Understanding Vietnamese Farmers’ Perception toward Forest Importance and Perceived Willingness-to-Participate in REDD+ Program: A Case Study in Nghe An Province
Authors: Khuc Quy Van , Pham Linh , Tran Mai , Nguyen Thuy , Tran Bao Quang , Hoang Tri , Ngo Thang , Tran Trung-Duc
Published: April 2021

Climate change continues to pose a constant threat to nature and human beings, and thus demands adaptability and flexibility in forestry and domestic land use management. In this context, the Reducing Emission from Deforestation and Forest Degradation (REDD+) project was introduced to harness forests to curb greenhouse gas emissions in an effort to combat climate change. As of 2020, REDD+ was implemented in 65 countries across the world, including Vietnam. While the missions of afforestation and forest protection cannot be accomplished without the aid of local residents, low participation from stakeholders, particularly poor farmers, is an obstacle in climate mitigation projects. To contribute to improving REDD+ with a useful Vietnam reference, this study uses a random sample approach coupled with a face-to-face interview method to survey 215 households in Chau Thai, one of 206 poor communes in Nghe An province, to learn about (1) residents’ perception towards the importance of forests, (2) how forests contribute as a source of livelihood, (3) potential for household engagement in REDD+. The research findings show that the important role of forests is well acknowledged, the majority of forestland was allocated to plantation forests, and the seeds are carefully selected to satisfy market demand. In addition, forests are recorded to make major contributions to residents’ income and roughly four-fifths of households revealed their willingness to get involved in the REDD+ project with a monthly subsidy of 500–2000 kVND (22.3–89.2 USD). The study provides valuable information about forest-based rural livelihood and policy options to facilitate REDD+ participation among farmers. This, in turn, helps devise more appropriate policies for climate change mitigation and sustainable rural mountainous development nationwide and beyond.
IoT Technologies during and Beyond COVID-19: A Comprehensive Review
Authors: Yousif Mohamed , Hewage Chaminda , Nawaf Liqaa
Published: April 2021

The COVID-19 pandemic provided a much-needed sanity check for IoT-inspired frameworks and solutions. IoT solutions such as remote health monitoring and contact tracing provided support for authorities to successfully manage the spread of the coronavirus. This article provides the first comprehensive review of key IoT solutions that have had an impact on COVID-19 in healthcare, contact tracing, and transportation during the pandemic. Each sector is investigated in depth; and potential applications, social and economic impact, and barriers for mass adaptation are discussed in detail. Furthermore, it elaborates on the challenges and opportunities for IoT framework solutions in the immediate post-COVID-19 era. To this end, privacy and security concerns of IoT applications are analyzed in depth and emerging standards and code of practices for mass adaptation are also discussed. The main contribution of this review paper is the in-depth analysis and categorization of sector-wise IoT technologies, which have the potential to be prominent applications in the new normal. IoT applications in each selected sector are rated for their potential economic and social impact, timeline for mass adaptation, and Technology Readiness Level (TRL). In addition, this article outlines potential research directions for next-generation IoT applications that would facilitate improved performance with preserved privacy and security, as well as wider adaptation by the population at large.
Effect of Medicago sativa Addition on Physicochemical, Nutritional and Functional Characteristics of Corn Extrudates
Authors: Igual Marta , Chiş Maria Simona , Socaci Sonia Ancuța , Vodnar Dan Cristian , Ranga Floricuța , Martínez-Monzó Javier , García-Segovia Purificación
Published: April 2021

Currently, extrudates are considered unhealthy products, being characterized as high in calories; rich in fat, sugar, and salt; and low in nutritional compounds. The aim of this study was to assess the influence of lucerne (Medicago sativa) on the physicochemical, nutritional, and functional characteristics of corn extrudates. In order to achieve these goals, water content, water activity, expansion index, bulk density, porosity, hygroscopicity, optical properties, antioxidant activity, individual phenolic acids, folates, individual flavonoids, and volatile compounds were analyzed. The results showed that the typical characteristics of corn extrudates such as expansion, crunchiness, and density were maintained with 10% lucerne addition, highlighting a strong negative Pearson correlation (p < 0.05) between all studied parameters and lucerne addition. On the other hand, the lucerne addition caused a linear increase of bioactive compounds, showing positive Pearson correlations between flavonoids, folates, and antioxidant activity. The volatile profile of corn extrudates improved with the addition of lucerne leading to volatile compounds such as limonene, β-mircene, and hexanal. Overall, considering the textural, nutritional, and functional characteristics of corn extrudates, we determined that a percentage addition on 10% lucerne could be successfully used in the manufacturing of corn extrudates.
Influence of Two Innovative Packaging Materials on Quality Parameters and Aromatic Fingerprint of Extra-Virgin Olive Oils
Authors: Farris Stefano , Buratti Susanna , Benedetti Simona , Rovera Cesare , Casiraghi Ernestina , Alamprese Cristina
Published: April 2021

The performance of two innovative packaging materials was investigated on two Sardinian extra-virgin olive oils (Nera di Gonnos and Bosana). In particular, a transparent plastic film loaded with a UV-blocker (packaging B) and a metallized material (packaging C) were compared each other and to brown-amber glass (packaging A). During accelerated shelf-life tests at 40 and 60 °C, the evolution of quality parameters (i.e., acidity, peroxide value, K270, and phenolic content) was monitored, together with the aromatic fingerprint evaluated by electronic nose. Packaging B resulted in the best-performing material in protecting oil from oxidation, due to its lower oxygen transmission rate (0.1 ± 0.02 cm3/m2 24 h) compared to packaging C (0.23 ± 0.04 cm3/m2 24 h). At the end of storage, phenolic reduction was on average 25% for packaging B and 58% for packaging C, and the aromatic fingerprint was better preserved in packaging B. In addition, other factors such as the sanitary status of the olives at harvesting and the storage temperature were demonstrated to have a significant role in the shelf life of packaged extra-virgin olive oil.
Anticholinesterase Activities of Different Solvent Extracts of Brewer’s Spent Grain
Authors: Birsan Rares I. , Wilde Peter , Waldron Keith W. , Rai Dilip K.
Published: April 2021

Cholinesterases, involved in acetylcholine catabolism in the central and peripheral nervous system, have been strongly linked with neurodegenerative diseases. Current therapeutic approaches using synthetic drugs present several side effects. Hence, there is an increasing research interest in naturally-occurring dietary polyphenols, which are also considered efficacious. Food processing by-products such as brewer’s spent grain (BSG) would be a potential bio-source of polyphenols. In this study, polyphenol-rich BSG extracts using 60% acetone and 0.75% NaOH solutions were generated, which were further subjected to liquid–liquid partitioning using various organic solvents. The water-partitioned fractions of the saponified extracts had the highest total polyphenol content (6.2 ± 2.8 mgGAE/g dw) as determined by Folin–Ciocalteu reagent, while the LC-MS/MS showed ethyl acetate fraction with the highest phenolics (2.9 ± 0.3 mg/g BSG dw). The best inhibitions of acetyl- (37.9 ± 2.9%) and butyryl- (53.6 ± 7.7%) cholinesterases were shown by the diethyl ether fraction of the saponified extract. This fraction contained the highest sum of quantified phenolics (99 ± 21.2 µg/mg of extract), and with significant (p < 0.01) inhibitory contribution of decarboxylated-diferulic acid. Amongst the standards, caffeic acid presented the highest inhibition for both cholinesterases, 25.5 ± 0.2% for acetyl- and 52.3 ± 0.8% for butyryl-cholinesterase, respectively, whilst the blends insignificantly inhibited both cholinesterases. The results showed that polyphenol-rich BSG fractions have potentials as natural anti-cholinesterase agents.
Identification of Potential Key lncRNAs in the Context of Mouse Myeloid Differentiation by Systematic Transcriptomics Analysis
Authors: Lan Yongqing , Li Meng , Mi Shuangli
Published: April 2021

Hematopoietic differentiation is a well-orchestrated process by many regulators such as transcription factor and long non-coding RNAs (lncRNAs). However, due to the large number of lncRNAs and the difficulty in determining their roles, the study of lncRNAs is a considerable challenge in hematopoietic differentiation. Here, through gene co-expression network analysis over RNA-seq data generated from representative types of mouse myeloid cells, we obtained a catalog of potential key lncRNAs in the context of mouse myeloid differentiation. Then, employing a widely used in vitro cell model, we screened a novel lncRNA, named Gdal1 (Granulocytic differentiation associated lncRNA 1), from this list and demonstrated that Gdal1 was required for granulocytic differentiation. Furthermore, knockdown of Cebpe, a principal transcription factor of granulocytic differentiation regulation, led to down-regulation of Gdal1, but not vice versa. In addition, expression of genes involved in myeloid differentiation and its regulation, such as Cebpa, were influenced in Gdal1 knockdown cells with differentiation blockage. We thus systematically identified myeloid differentiation associated lncRNAs and substantiated the identification by investigation of one of these lncRNAs on cellular phenotype and gene regulation levels. This study promotes our understanding of the regulation of myeloid differentiation and the characterization of roles of lncRNAs in hematopoietic system.
Palliative Care in Advanced Dementia: Comparison of Strategies in Three Countries
Authors: Sternberg Shelley A. , Shinan-Altman Shiri , Volicer Ladislav , Casarett David J. , van der Steen Jenny T.
Published: April 2021

Palliative care including hospice care is appropriate for advanced dementia, but policy initiatives and implementation have lagged, while treatment may vary. We compare care for people with advanced dementia in the United States (US), The Netherlands, and Israel. We conducted a narrative literature review and expert physician consultation around a case scenario focusing on three domains in the care of people with advanced dementia: (1) place of residence, (2) access to palliative care, and (3) treatment. We found that most people with advanced dementia live in nursing homes in the US and The Netherlands, and in the community in Israel. Access to specialist palliative and hospice care is improving in the US but is limited in The Netherlands and Israel. The two data sources consistently showed that treatment varies considerably between countries with, for example, artificial nutrition and hydration differing by state in the US, strongly discouraged in The Netherlands, and widely used in Israel. We conclude that care in each country has positive elements: hospice availability in the US, the general palliative approach in The Netherlands, and home care in Israel. National Dementia Plans should include policy regarding palliative care, and public and professional awareness must be increased.
Student Health Implications of School Closures during the COVID-19 Pandemic: New Evidence on the Association of e-Learning, Outdoor Exercise, and Myopia
Authors: Liu Ji , Li Baihuiyu , Chen Qiaoyi , Dang Jingxia
Published: April 2021

The coronavirus disease 2019 (COVID-19) pandemic forced many education systems to consider alternative remote e-learning modalities, which have consequential behavioral and health implications for youth. In particular, increased e-learning engagement with digital screens and reduction in outdoor activities are two likely channels posing adverse risks for myopia development. This study investigated the association between e-learning screen use, outdoor activity, lighting condition, and myopia development among school-age children in China, during the first wave of the COVID-19 pandemic. Data were collected from 3405 school-age children attending primary, lower-secondary, and upper-secondary schools in China. Univariate parametric and nonparametric tests, and multivariate logistic regression analysis were used. Findings show that each diopter hour increase in daily e-learning screen use is significantly associated with progression of myopia symptoms (OR: 1.074, 95% CI: 1.058–1.089; p < 0.001), whereas engaging in outdoor exercise four to six times per week (OR: 0.745, 95% CI: 0.568–0.977; p = 0.034) and one to three times per week (OR: 0.829, 95% CI: 0.686–0.991; p = 0.048) is associated with a lower likelihood of myopia progression than none at all. In addition, we found that indoor lighting that is either “too dim” (OR: 1.686, 95% CI: 1.226–2.319; p = 0.001) or “too bright” (OR: 1.529, 95% CI: 1.007–2.366; p = 0.036) is significantly associated higher likelihood of myopic symptoms. Findings in this study uncover the less observable vision consequences of the COVID-19 pandemic on youths through digital online learning and highlight the importance of considering appropriate mitigation strategies to deal with this emerging public health challenge.
Implementation of Physical Activity in US Elementary Schools: The Role of Administrative Support, Financial Resources, and Champions
Authors: Densley Blake , Calvert Hannah G. , Boedeker Peter , Turner Lindsey
Published: April 2021

The intentional integration of physical activity in elementary school classrooms—including brief instructional breaks for activity, or integration into lessons—can benefit children’s physical activity and education outcomes. Teachers are key implementation agents, but despite physical activity in the classroom being an evidence-informed practice, many teachers do not regularly implement it. The aim of this study was to obtain updated nationally representative prevalence estimates in United States public elementary schools, regarding four key outcomes: (1) school adoption of physically active lessons (PA lessons); (2) school adoption of physical-activity breaks (PA breaks); (3) penetration in the classroom, defined as ≥50% of teachers using PA breaks; and (4) dose, defined as an average of at least 50 min per week of PA breaks. We examined variations in outcomes by school demographic characteristics, and by three factors hypothesized to be implementation facilitators (administrative support, financial resources, and presence of a wellness champion at the school). In the 2019–20 school year, surveys were distributed to a nationally representative sample of 1010 public elementary schools in the US; responses were obtained from 559 (55.3%). The weighted prevalence of schools reporting adoption of PA lessons was 77.9% (95% CI = 73.9% to 81.9%), and adoption of PA breaks was nearly universal at 91.2% (95% CI = 88.4% to 94.1%). Few demographic differences emerged, although adoption of PA lessons was less prevalent at higher-poverty schools (73.9%) and medium-poverty schools (77.0%) as compared to schools with lower poverty levels (87.1%; p < 0.01). Across all four outcomes, associations emerged with facilitators in multivariable logistic regression models. The prevalence of adoption of PA lessons, adoption of PA breaks, and dose of PA breaks were all significantly higher at schools where administrative encouragement occurred more frequently. Financial support was associated with implementation outcomes, including adoption of PA lessons, and penetration and dose of PA breaks. Presence of a champion was associated with higher prevalence of reporting adoption of PA lessons. School leaders can play a crucial role in supporting teachers’ implementation of PA breaks and lessons in the classroom, through providing financial resources, encouragement, and supporting champions. Effective school-leadership practices have the potential to positively impact students at a large-scale population level by supporting implementation of PA lessons and breaks.
Muscle Performance Changes with Age in Active Women
Authors: Miller Ryan M. , Freitas Eduardo D. S. , Heishman Aaron D. , Peak Keldon M. , Buchanan Samuel R. , Kellawan J. Mikhail , Pereira Hugo M. , Bemben Debra A. , Bemben Michael G.
Published: April 2021

The purpose of this study was to examine age-related differences in muscle performance in women divided into young (YW, 20–39 years, n = 29) middle-aged (MAW, 40–59 years, n = 33), and older (OW, ≥60 years, n = 40) age groups. Methods: Hand grip strength, vertical jump performance, and knee extensor (KE) strength (0 deg/s, 60 deg/s, and 240 deg/s), speed of movement (SoM; at 1 Nm, 20%, 40%, and 60% isometric strength), and endurance (30-repetition test at 60 degs/s and 240 deg/s) were assessed. Computed tomography-acquired muscle cross-sectional area (mCSA) was measured and included to determine specific strength (KE strength/mCSA). Results: Hand grip strength was similar across groups, while jump performance declined with age (YW and MAW > OW, p < 0.001). KE strength declined significantly with age (all conditions p < 0.01), while specific strength was similar across groups. SoM was significantly higher for YW and MAW compared to OW (both p < 0.01). An age × velocity interaction revealed YW KE endurance was similar between conditions, whereas MAW and OW displayed significantly better endurance during the 60 deg/s condition. OW displayed impaired KE endurance at 240 deg/s (vs. YW and MAW, p < 0.01) but improved at 60 deg/s (vs. YW, p < 0.01). Dynamic torque decline increased with age (YW < OW, p = 0.03) and was associated with intramuscular adipose tissue (r = 0.21, p = 0.04). Conclusions: Performance declines were most evident among OW, but few performance deficits had emerged in MAW. Interestingly, strength declines disappeared after normalizing to mCSA and endurance appears to be velocity-dependent.
Greenhouse Gas Emission Inefficiency Spillover Effects in European Countries
Authors: Kutlu Levent , Wang Ran
Published: April 2021

In our study, we examine whether spatial spillover effects exist for greenhouse gas emission efficiency for 38 European countries between 2005 and 2014. We find that inefficiencies of other countries would lead to lower efficiency levels for a country. This negative inefficiency spillover effect goes down till 2008 then goes up till 2011, then stays relatively stable after 2011. Any strategy to reduce inefficiencies of other countries could potentially improve the efficiency levels. We find that human development index shows significant positive impact on greenhouse gas emission efficiency levels. In particular, one standard deviation increase in human development index would lead to a 11.12 percentage points increase in the greenhouse gas emission efficiencies on average. Different countries show different efficiency levels and efficiency growth patterns over time. However, the pattern of spatial spillover is quite similar among all countries over time.
Understanding the Health Behavior Decision-Making Process with Situational Theory of Problem Solving in Online Health Communities: The Effects of Health Beliefs, Message Credibility, and Communication Behaviors on Health Behavioral Intention
Authors: Xu Xiaoting , Li Honglei , Shan Shan
Published: April 2021

Online health communities (OHCs) offer users the opportunity to share and seek health information through these platforms, which in turn influence users’ health decisions. Understanding what factors influence people’s health decision-making process is essential for not only the design of the OHC, but also for commercial health business who are promoting their products to patients. Previous studies explored the health decision-making process from many factors, but lacked a comprehensive model with a theoretical model. The aim of this paper is to propose a research model from the situational theory of problem solving in relation to forecasting health behaviors in OHCs. An online questionnaire was developed to collect data from 321 members of online health communities (HPV Tieba and HPV vaccina Tieba) who have not received an HPV vaccination. The partial least squares structural equation modeling (PLS-SEM) method was employed for the data analysis. Findings showed that information selection and acquisition is able to forecast HPV vaccination intentions, perceived seriousness and perceived susceptibility can directly impact HPV vaccination intention and have an indirect impact by information selection and acquisition, and perceived message credibility indirectly affected HPV vaccination intention via information selection. The current paper supports health motivations analysis in OHCs, with potential to assist users’ health-related decision-making.
Activated Olive Stones as a Low-Cost and Environmentally Friendly Adsorbent for Removing Cephalosporin C from Aqueous Solutions
Authors: León Gerardo , Saura Francisco , Hidalgo Asunción María , Miguel Beatriz
Published: April 2021

In this paper, we describe the removal of cephalosporin C (CPC) from aqueous solutions by adsorption onto activated olive stones (AOS) in a stirred tank. For comparative purposes, several experiments of adsorption onto commercial granular activated carbon were carried out. A quantum study of the different species of cephalosporin C that, depending on the pH, exist in aqueous solution pointed to a favorable mass transfer process during adsorption. Activated olive stones were characterized by SEM, EDX and IR techniques and their pHzc was determined. A 10−3 M HCl cephalosporin C solution has been selected for the adsorption experiments because at the pH of that solution both electrostatic and hydrogen bond interactions are expected to be established between the adsorbate and the adsorbent. The adsorption process is best described by the Freundlich isotherm model and the pseudo-second-order kinetic model, while the adsorption mechanism is mainly controlled by film diffusion. Under the conditions studied, the adsorption process is of a physical nature, endothermic and spontaneous. Comparison of the adsorption results obtained in this paper with those of other authors shows that the efficiency of AOS is 20% of that of activated carbon but 65% higher than that of the XAD-2 adsorbent. Considering its low price, abundance, easy accessibility and eco-compatibility, the use of activated olive stones as adsorbents for the removal of emerging pollutants from aqueous solutions represents an interesting possibility from both the economic and the environmental points of view.
Exploring Dog-Assisted Interventions in Higher Education: Students’ Attitudes and Perceived Effects on Well-Being
Authors: Rothkopf Cathrin , Schworm Silke
Published: April 2021

Both, in the transition to university and during it, students experience a multitude of different changes. Thus, it is no surprise that many students in higher education report suffering from mental health problems. To address their concerns, animal-assisted interventions (AAIs) have gained more and more attention over the past few years. Nonetheless, AAIs have neither yet been used nor researched at German universities. Two studies were carried out to address this issue. In Study I, 709 university students answered a questionnaire evaluating their attitude towards dogs, AAIs and interest in its use at their home university. In Study II, 27 students participated in a dog-assisted intervention (DAI) in which they were allowed to interact with a qualified dog for 15 min. To gain information about their well-being, blood pressure was measured and the Basler Befindlichkeitsskala had to be answered before and after the intervention. Results showed a positive attitude among German students toward dogs, AAIs, and the use of DAIs at their home university. Although an effect on physical well-being could not be found, results showed that a 15-min DAI can improve students’ psychological well-being. Thus, higher education administrators should consider using DAIs as a way to improve student well-being.
Mood States and Performance in Elite Canoe Polo Players: The Mediating Role of Stress
Authors: Di Corrado Donatella , Buscemi Andrea , Magnano Paola , Maldonato Nelson Mauro , Tusak Matej , Coco Marinella
Published: April 2021

Sport performance is characterized by competitive stressful conditions that elicit emotional states. The purpose of the study was to examine whether stress mediated the relationship between mood states and performance. Thirty-two elite canoe polo players from four different Italian teams (16 senior males and 16 senior females), aged between 29 and 38 years old (M = 32.3, SD = 2.71), participated in the study. Measures included level of psychological stress, six mood dimensions, and performance outcome. We also detected the digit ratio—the lower second-to-fourth digit length (2D:4D) ratio—as it was demonstrated to be correlated to high sports performance. The assessment took place one day before the first game of the national competition “ITALY CUP”. Male athletes reported lower scores on dysfunctional emotion-related states and on 2D:4D ratio than female athletes. The results of the mediation analysis showed that psychological stress plays a mediating role between moods and performance. Overall, given the limited literature, the findings supported an integrative approach to the study of the linkage between emotion and action in canoe polo.
Unraveling Urban Form and Collision Risk: The Spatial Distribution of Traffic Accidents in Zanjan, Iran
Authors: Kalantari Mohsen , Zanganeh Shahraki Saeed , Yaghmaei Bamshad , Ghezelbash Somaye , Ladaga Gianluca , Salvati Luca
Published: April 2021

Official statistics demonstrate the role of traffic accidents in the increasing number of fatalities, especially in emerging countries. In recent decades, the rate of deaths and injuries caused by traffic accidents in Iran, a rapidly growing economy in the Middle East, has risen significantly with respect to that of neighboring countries. The present study illustrates an exploratory spatial analysis’ framework aimed at identifying and ranking hazardous locations for traffic accidents in Zanjan, one of the most populous and dense cities in Iran. This framework quantifies the spatiotemporal association among collisions, by comparing the results of different approaches (including Kernel Density Estimation (KDE), Natural Breaks Classification (NBC), and Knox test). Based on descriptive statistics, five distance classes (2–26, 27–57, 58–105, 106–192, and 193–364 meters) were tested when predicting location of the nearest collision within the same temporal unit. The empirical results of our work demonstrate that the largest roads and intersections in Zanjan had a significantly higher frequency of traffic accidents than the other locations. A comparative analysis of distance bandwidths indicates that the first (2–26 m) class concentrated the most intense level of spatiotemporal association among traffic accidents. Prevention (or reduction) of traffic accidents may benefit from automatic identification and classification of the most risky locations in urban areas. Thanks to the larger availability of open-access datasets reporting the location and characteristics of car accidents in both advanced countries and emerging economies, our study demonstrates the potential of an integrated analysis of the level of spatiotemporal association in traffic collisions over metropolitan regions.
Reaching out for Help: Calls to a Mental Health Helpline Prior to and during the COVID-19 Pandemic
Authors: Scerri Josianne , Sammut Alexei , Cilia Vincenti Sarah , Grech Paulann , Galea Michael , Scerri Christian , Calleja Bitar Daniela , Dimech Sant Stephania
Published: April 2021

The COVID-19 pandemic is a major health crisis associated with adverse mental health consequences. This study examined 2908 calls made to a national mental health helpline over a 10 month period, 2 months prior to (Pre-COVID) and 8 months during the pandemic phase, that incorporated the imposition of a partial lockdown, followed by the removal and reintroduction of restrictive measures locally. Data collected included reason/s for call assistance, gender, age and number of daily diagnosed cases and deaths due to COVID-19. In the Pre-COVID phase, calls for assistance were related to information needs and depression. With the imposition of a partial lockdown, coupled with the first local deaths and spikes in number of diagnosed cases, a significant increase in number of calls targeting mental health, medication management and physical and financial issues were identified. Following the removal of local restrictions, the number of calls decreased significantly; however, with the subsequent reintroduction of restrictions, coupled with the rise in cases and deaths, assistance requested significantly targeted informational needs. Hence, whilst calls in the initial phase of the pandemic mainly targeted mental health issues, over time this shifted towards information seeking requests, even within a context where the number of deaths and cases had significantly risen.
Response of Knee Extensor Muscle-Tendon Unit Stiffness to Unaccustomed and Repeated High-Volume Eccentric Exercise
Authors: Muanjai Pornpimol , Mickevicius Mantas , Snieckus Audrius , Jones David A. , Zachovajevas Pavelas , Satkunskiene Danguole , Venckunas Tomas , Kamandulis Sigitas
Published: April 2021

The purposes of this study were to investigate the muscle-tendon unit stiffness response and to compare the stiffness with those of other indirect markers induced by two bouts of unaccustomed eccentric exercise. Eleven untrained men performed two bouts of 200 maximal eccentric contractions of the right quadriceps 4 weeks apart. Changes in stiffness, pain evoked by stretching and pressure, plasma creatine kinase (CK) activity, and muscle thickness were followed for 7 days after each bout. Stiffness and pain peaked immediately and 1 day after the first exercise bout, whereas CK and thickness were highest 4 and 7 days after the first exercise bout, respectively (p < 0.05 for all). Muscular pain, thickness, and stiffness responses were lower by 53.3%, 99%, and 11.6%, respectively, after the repeated bout compared to after the first bout (p < 0.05 for all), while CK activity response did not differ significantly between bouts. High responders for an increase in muscle-tendon unit stiffness showed a repeated-bout effect for stiffness, pain, and CK activity (by 29%, 65%, and 98%, p < 0.05 for all), but the repeated-bout effect was not that clear in low responders. These findings suggest that a repeated eccentric exercise bout effect on stiffness in quadriceps is mostly not associated with muscle pain and CK activity, but there are large individual differences.
Contribution of Plantar Fascia and Intrinsic Foot Muscles in a Single-Leg Drop Landing and Repetitive Rebound Jumps: An Ultrasound-Based Study
Authors: Morikawa Masanori , Maeda Noriaki , Komiya Makoto , Hirota Arisu , Mizuta Rami , Kobayashi Toshiki , Kaneda Kazuki , Nishikawa Yuichi , Urabe Yukio
Published: April 2021

The plantar fascia and intrinsic foot muscles (IFM) modulate foot stiffness. However, it is unclear whether the corresponding ultrasonography findings reflect it. This study aimed to examine the effect of the plantar fascia and IFM morphologies on force attenuation during landing and reactivity when jumping in healthy adults (n = 21; age, 21–27 years). Thickness, cross-sectional area (CSA), and hardness of the plantar fascia, abductor hallucis (AbH), and flexor hallucis brevis (FHB) muscles were measured using ultrasonography. Single-leg drop landing and repetitive rebound jumping tests assessed the ground reaction force (GRF) and reactive jump index (RJI), respectively. The CSA of FHB was negatively correlated with maximum vertical GRF (r = −0.472, p = 0.031) in the single-leg drop landing test. The CSA of AbH was negatively correlated with contact time (r = −0.478, p = 0.028), and the plantar fascia thickness was positively correlated with jump height (r = 0.615, p = 0.003) and RJI (r = 0.645, p = 0.002) in the repetitive bound jump test. In multivariate regression analysis, only the plantar fascia thickness was associated with RJI (β = 0.152, 95% confidence interval: 7.219–38.743, p = 0.007). The CSA of FHB may contribute to force attenuation during landing. The thickness of the plantar fascia and CSA of AbH may facilitate jumping high with minimal contact time.
The Health and Development of Young Children Who Witnessed Their Parent’s Arrest Prior to Parental Jail Incarceration
Authors: Poehlmann-Tynan Julie , Muentner Luke , Pritzl Kaitlyn , Cuthrell Hilary , Hindt Lauren A. , Davis Laurel , Shlafer Rebecca
Published: April 2021

Most U.S. incarceration occurs in jails, with more than 10 million annual admissions, and most individuals in jail are parents of minor children. In this short-term longitudinal study, we examined the health and development of young children who did or did not witness their parent’s arrest prior to parental jail incarceration. 228 individuals in 76 triads (incarcerated parents, children, at-home caregivers) were enrolled from four jails in two states. Jailed parents and caregivers reported on whether the child witnessed the parent’s arrest or crime. Children’s caregivers completed questionnaires about children’s emotional symptoms during the prior 6 months and demographics, as well as children’s emotional reactions to separation from the parent and child health at the initial assessment and 2 weeks later. Trained researchers conducted a developmental assessment with children while waiting to visit parents. Results of regression-based moderated mediation analyses indicated that when their emotional symptoms were high, children who witnessed parental arrest were more likely to have poorer health initially and more intense negative reactions to the parent leaving for jail. In addition, when children’s general emotional symptoms were low, children who witnessed their parent’s arrest were more likely to exhibit developmental delays, especially in their early academic skills, compared to children who did not witness the arrest. Witnessing the parent’s crime related to missed milestones in social and adaptive development. Findings have implications for policies regarding safeguarding children during parental arrest and referrals for health- and development-promotion services following parental criminal justice system involvement.
3D Visibility Analysis for Evaluating the Attractiveness of Tourism Routes Computed from Social Media Photos
Authors: Mor Matan , Fisher-Gewirtzman Dafna , Yosifof Roei , Dalyot Sagi
Published: April 2021

Social media is used nowadays for various location-based applications and services, aspiring to use the vast and timely potential of user-generated content. To evaluate the correctness, reliability and potential of these applications and services, they are mostly evaluated in terms of optimization or compared to existing authoritative data sources and services. With respect to route planning, criterion optimization is mostly implemented to evaluate the service effectiveness, in terms of, e.g., length, time or visited places. These evaluations are mostly limited in their effectiveness at presenting the complete experience of the route, since they are limited to a predefined criterion and are mostly implemented in two-dimensional space. In this research, we propose a comprehensive evaluation process, in which a tourism walking route is analyzed with respect to three-dimensional visibility that measures the attractiveness of the route relating to the user perception. To present our development, we showcase the use of Flickr, a social media photo-sharing online website that is popular among travelers that share their tourism experiences. We use Flickr photos to generate tourism walking routes and evaluate them in terms of the visible space. We show that the 3D visibility analysis identifies the various visible urban elements in the vicinity of the tourism routes, which are more attractive, scenery and include many tourism attractions. Since urban attractivity is often reflected in the photo-trails of Flickr photographers, we argue that using 3D visibility analysis that measures urban attractiveness and scenery should be considered for the purpose of analysis and evaluation of location-based services.
Transthyretin Misfolding, A Fatal Structural Pathogenesis Mechanism
Authors: Si Jin-Beom , Kim Bokyung , Kim Jin Hae
Published: April 2021

Transthyretin (TTR) is an essential transporter of a thyroid hormone and a holo-retinol binding protein, found abundantly in human plasma and cerebrospinal fluid. In addition, this protein is infamous for its amyloidogenic propensity, causing various amyloidoses in humans, such as senile systemic amyloidosis, familial amyloid polyneuropathy, and familial amyloid cardiomyopathy. It has been known for over two decades that decreased stability of the native tetrameric conformation of TTR is the main cause of these diseases. Yet, mechanistic details on the amyloidogenic transformation of TTR were not clear until recent multidisciplinary investigations on various structural states of TTR. In this review, we discuss recent advancements in the structural understanding of TTR misfolding and amyloidosis processes. Special emphasis has been laid on the observations of novel structural features in various amyloidogenic species of TTR. In addition, proteolysis-induced fragmentation of TTR, a recently proposed mechanism facilitating TTR amyloidosis, has been discussed in light of its structural consequences and relevance to acknowledge the amyloidogenicity of TTR.
The Effects of Cryogenic Storage on Human Dental Pulp Stem Cells
Authors: Pilbauerova Nela , Schmidt Jan , Soukup Tomas , Koberova Ivancakova Romana , Suchanek Jakub
Published: April 2021

Dental pulp stem cells (DPSCs) are a type of easily accessible adult mesenchymal stem cell. Due to their ease of access, DPSCs show great promise in regenerative medicine. However, the tooth extractions from which DPSCs can be obtained are usually performed at a period of life when donors would have no therapeutic need of them. For this reason, it is imperative that successful stem cell storage techniques are employed so that these cells remain viable for future use. Any such techniques must result in high post-thaw stem cell recovery without compromising stemness, proliferation, or multipotency. Uncontrolled-rate freezing is not a technically or financially demanding technique compared to expensive and laborious controlled-rate freezing techniques. This study was aimed at observing the effect of uncontrolled-rate freezing on DPSCs stored for 6 and 12 months. Dimethyl sulfoxide at a concentration of 10% was used as a cryoprotective agent. Various features such as shape, proliferation capacity, phenotype, and multipotency were studied after DPSC thawing. The DPSCs did not compromise their stemness, viability, proliferation, or differentiating capabilities, even after one year of cryopreservation at −80 °C. After thawing, they retained their stemness markers and low-level expression of hematopoietic markers. We observed a size reduction in recovery DPSCs after one year of storage. This observation indicates that DPSCs can be successfully used in potential clinical applications, even after a year of uncontrolled cryopreservation.
Role of Virally-Encoded Deubiquitinating Enzymes in Regulation of the Virus Life Cycle
Authors: Proulx Jessica , Borgmann Kathleen , Park In-Woo
Published: April 2021

The ubiquitin (Ub) proteasome system (UPS) plays a pivotal role in regulation of numerous cellular processes, including innate and adaptive immune responses that are essential for restriction of the virus life cycle in the infected cells. Deubiquitination by the deubiquitinating enzyme, deubiquitinase (DUB), is a reversible molecular process to remove Ub or Ub chains from the target proteins. Deubiquitination is an integral strategy within the UPS in regulating survival and proliferation of the infecting virus and the virus-invaded cells. Many viruses in the infected cells are reported to encode viral DUB, and these vial DUBs actively disrupt cellular Ub-dependent processes to suppress host antiviral immune response, enhancing virus replication and thus proliferation. This review surveys the types of DUBs encoded by different viruses and their molecular processes for how the infecting viruses take advantage of the DUB system to evade the host immune response and expedite their replication.
Optimization Model for the Supply Volume of Bike-Sharing: Case Study in Nanjing, China
Authors: Yu Jiajie , Ji Yanjie , Yi Chenyu , Kuai Chenchen , Samal Dmitry Ivanovich
Published: April 2021

In order to solve the oversupply and repositioning problems of bike-sharing, this paper proposes an optimization model to obtain a reasonable supply volume scheme for bike-sharing and infrastructure configuration planning. The optimization model is constrained by the demand for bike-sharing, urban traffic carrying capacity (road network and parking facilities carrying capacities), and the flow conservation of shared bikes in each traffic analysis zone. The model was formulated through mixed-integer programming with the aim of minimizing the total costs for users and bike-sharing enterprises (including the travel cost of users, production and maintenance costs of shared bikes, and repositioning costs). CPLEX was used to obtain the optimal solution for the model. Then, the optimization model was applied to 183 traffic analysis zones in Nanjing, China. The results showed that not only were user demands met, but the load ratios of the road network and parking facilities with respect to bike-sharing in each traffic zone were all decreased to lower than 1.0 after the optimization, which established the rationality and effectiveness of the optimization results.