bluuebunny/crossref_metadata_2025 huggingface dataset:
The Anti-Cancer Properties of Niyog Niogan (Quisqualis indica), Tsaang Gubat (Carmona retusa), and Pansit Pansitan (Peperomia pellucida)
Authors: Jularbal Benjamin
Published: January 2025

Cancer continues to be one of the leading causes of death both in the Philippines and worldwide. Chemotherapeutic agents have long been used to inhibit the growth of cancer cells; however, many of these agents face significant challenges such as drug resistance and toxicity to normal cells. As a result, there has been a growing interest in the development of new classes of anti-cancer agents that exhibit more efficient and selective toxicity. In the Philippines, the Department of Health (DOH) has approved ten herbal medicines for use as home remedies for various diseases. However, of these, Quisqualis indica, Carmona retusa, and Peperomia pellucida have not been extensively studied for their potential anti-cancer properties. Therefore, it is crucial to investigate the potential of these plants in the fight against cancer. This study utilized four biological assays to evaluate the anti-cancer properties of Quisqualis indica, Carmona retusa, and Peperomia pellucida. The results demonstrated that the methanolic extracts from these plants were effective in inhibiting angiogenesis, as shown in both the CAM and HUVEC assays. Additionally, the extracts were found to significantly reduce the expression levels of VEGFR-1, VEGFR-2, and CD-34, while increasing the expression of TGF-β1. Furthermore, the plant extracts exhibited cytotoxic effects on human breast cancer (MCF-7) cells, with a decrease in cell viability attributed to apoptosis, characterized by extensive DNA fragmentation. These findings suggest that Quisqualis indica, Carmona retusa, and Peperomia pellucida hold promise as sources of natural anti-cancer agents. Future studies should aim to identify the specific bioactive compounds present in these plants and further explore their effects on different cancer cell lines.
Female fertility preservation: why it does not always mean preservation of fertility
Authors: Capodanno Francesco , Anastasi Attilio , Bonesi Francesca , Cinti Marialuisa , Gallinelli Andrea
Published: January 2025

The risk of cancer-related infertility is high for some diseases, but still unclear for others. Due to numerous confounding factors, it is difficult to clarify the impact of cancer itself on female fertility. Oocyte and ovarian tissue cryopreservation offer many cancer patients an opportunity to achieve genetic parenthood, but the real efficacy of the method in terms of live births is still unknown. Since not all women with cancer are at risk of infertility, a customized approach, taking into account the type of disease and therapy, is required in order to optimize female fertility preservation method choice, efficacy and cost-effectiveness. This mini-review focuses on the efficacy of female fertility preservation by oocyte and ovarian tissue cryopreservation, in order to provide some useful tips for oncofertility counseling. KEY WORDS: Female fertility, fertility preservation, vitrification, oocytes, male breast cancer, fertility preservation efficacy, ovarian tissue.
Successful in vitro fertilization pregnancy (IVF) after conservative management of endometrial cancer
Authors: Sorce Silvia , Castello Claudio
Published: January 2025

Objective: To report a successful IVF pregnancy in a couple after conservative treatment of endometrial cancer. DesignDesign: Case report and literature review. SettingSetting: ASL città di Torino – SC PMA, Valdese dpt. Patient(s)s): A 32-year-old white woman. Main Outcome Measure(s)s): Successful pregnancy after conservative management of endometrial cancer. Intervention(s)s): Grade 1 endometrial adenocarcinoma diagnosed at hysteroscopy, followed by dilatation and curettage (D&C). On follow-up D&C, pathologic examination was normal after high-dose progesterone therapy. The patient subsequently underwent an IVF cycle with transfer of one embryo. Result(s)s): The patient delivered a baby boy with a vaginal delivery at 37 weeks of gestational age. She is currently undergoing follow-up, and hysterectomy and bilateral salpingo-oophorectomy have not yet been performed. Conclusion(s)s): In carefully chosen situations, deferring surgery in infertile patients with endometrial cancer may be a viable option permitting subsequent successful pregnancy. KEY WORDS: IVF, endometrial cancer, save fertility, pregnancy conservative management.
Modeling Hourly Productivity of Advanced Practice Clinicians in the Emergency Department
Authors: Stenson Bryan A. , Antkowiak Peter S. , Chiu David T. , Sanchez Leon D. , Joseph Joshua W.
Published: January 2025

Introduction: Advance practice clinicians (APC) play signiﬁcant roles in academic and community emergency departments (ED). In attendings and residents, prior research demonstrated that productivity is dynamic and changes throughout a shift in a predictable way. However, this has not been studied in APCs. The primary outcome of this study was to model productivity for APCs in community EDs to determine whether it changes during a shift similar to the way it does for attendings and residents. Methods: This was a retrospective, observational analysis of 10-hour APC shifts at two suburban hospitals, worked by 14 total individuals. We examined the number of patients seen per hour of the shift by experienced APCs who see all acuity and staff all patients with an attending. We used a generalized estimating equation to construct the model of hour-by-hour productivity change. Results: We analyzed 862 shifts over one year across two sites, with three shift start times. Site 1 10 AM–8 PM saw an average of 13.31 (95% conﬁdence interval [CI] 13.02–13.63) patients per shift; Site 2 8 AM–6 PM saw an average of 12.64 (95% CI 12.32–13.06) patients per shift; Site 2 4 PM–2 AM saw an average of 12.53 (95% CI 12.04–12.82) patients per shift. Across all sites and shifts, hour 1 saw the highest number of patients. Each subsequent hour was associated with a small, statistically signiﬁcant decrease over the previous hours. This was most pronounced in the shift’s last two hours. Conclusion: The productivity of APCs demonstrates a similar pattern of hourly declines observed in both resident and attending physicians. This corroborates prior ﬁndings that patients per hour is a dynamic variable, decreasing throughout a shift. This provides further external validity to prior research to include both APCs and community EDs. These departments must take this phenomenon into account, as it has scheduling and operational consequences.
Analisis Perkerasan Kaku (Rigid Pavement) dengan Mutu Beton Fs’45 terhadap Kuat Tekan dan Lentur
Authors: Setiawan Riki , Supratman Odih
Published: January 2025

Penelitian ini bertujuan untuk menganalisis penggunaan beton mutu FS 45 pada perkerasan kaku (rigid pavement) dalam rekonstruksi ruas Jalan Baros-Petir. Beton FS 45, dengan kuat tekan minimum 45 MPa dan kuat lentur 5–6 MPa, dirancang untuk menangani beban lalu lintas berat, khususnya kendaraan berat seperti truk. Pengujian melibatkan analisis kuat tekan dan lentur beton menggunakan sampel silinder berdiameter 150 mm dan tinggi 300 mm serta balok berukuran 150 mm x 150 mm x 600 mm pada umur 7 dan 28 hari. Proses pencampuran beton mengacu pada formula desain (Design Mix Formula) dengan proporsi material yang disesuaikan untuk memastikan kekuatan optimal. Hasil menunjukkan bahwa beton FS 45 memiliki kuat tekan rata-rata sebesar 42,81 MPa dan kuat lentur rata-rata sebesar 5,5 MPa, memenuhi standar mutu minimum yang disyaratkan, yaitu masing-masing 39,7 MPa dan 4,4 MPa. Beton ini terbukti memberikan daya tahan tinggi terhadap beban lalu lintas berat, meningkatkan umur layanan perkerasan, dan mengurangi biaya pemeliharaan jangka panjang. Faktor-faktor seperti kondisi tanah dasar, drainase, dan proses konstruksi diidentifikasi sebagai elemen penting dalam keberhasilan implementasi perkerasan kaku. Penelitian ini memberikan kontribusi penting dalam meningkatkan infrastruktur transportasi yang lebih tahan lama dan efisien, terutama pada jalan-jalan dengan intensitas lalu lintas tinggi.
Results for SL (2, p), p=3,5 and 7
Authors: Jasim Niran Sabah , Kirdar Mohammed Serdar I. , Yasin Mohammed , Smeein Shrooq Bahjat , Al Hajri Amal Rashid
Published: January 2025

The collection of whole  - account grade maps respecting a restricted group G of commutative group cf (G,Z) beneath spot wise addendum. Into these one group own  - account generalized characters a subgroup indicate R(G).
Whole invertible   ´  model form a group on a field F indicate ( ,F). A homo. of GL(n,F) to F-{0} is the determinant of these model, ( ,F) indicate the kernel of it. Thus ( ,F) is a subgp. of ( ,F) include whole models of determinant 1 on F.
Let  vector void on F,  indicate whole linear isomo. of V  upon same, a representation of G for representation void  is a homo. of  to . A representation model of  is a homo. of  to , where  is the degree of the representation model.
From the rational representations character table (CTRR) we compute the cyclic decomposition (CD) for , and 7 to  (2, ).
Chemical Reaction and Activation Energy Impacts on Unsteady Radiative Flow of Sisko Fluid
Authors: Rehman Wahid , De Azevedo Fabio Souto , Ullah Shakir
Published: January 2025

In this work, we study the two-dimensional boundary layer flow of Sisko fluid over stretching surface. Further we have observed, the effect of chemical reaction and activation energy on unsteady radiative flow of Sisko fluid. The suitable transformations are used to convert non-linear partial differential equations (PDEs) into ordinary differential equations (ODEs). Numerical solutions are obtained for the velocity, temperature and concentration profiles by utilizing the bvp4c technique. The effect of various parameters on the heat transfer and concentration profiles are depicted in the graphs and tables are briefly discussed.
Innovating Coffee Production: Integrating Anaerobic Carbonic Maceration Technology to Achieve International Standards
Authors: Wardani Dyah Kusuma , Ambarkahi Ratih Puspitorini Yekti , Chairina Raden Roro Lia , Andini Paramita , Putra Dhanang Eka
Published: January 2025

In the coffee industry, product quality is a key factor in competing in the international market. The Teaching Factory (TEFA) at Polije faces challenges in maintaining quality consistency and meeting international standards. This study aims to implement Anaerobic Carbonic Maceration (ACM) technology in the coffee fermentation process at TEFA Polije to enhance the quality of the produced coffee. The methods used include technical training for workers on the operation and maintenance of ACM technology, the application of strict quality protocols, and the optimization of the logistics system from raw material management to product distribution. Data were collected through sensory evaluation and interviews with workers. The results indicate that the implementation of ACM technology significantly improves the coffee’s aroma and flavor profile, as well as the consistency of bean texture, aligning with international standards. The evaluation shows that 80% of workers were able to operate the technology correctly, and 75% of the products met premium standards after implementation. The conclusion of this study is that ACM technology is effective in improving the quality of TEFA Polije coffee while also creating opportunities for expansion into the international market.
Pengaruh Konsep Diri terhadap Asertivitas Siswa SMA Negeri 15 Padang
Authors: Firdaus Hariandi Viky , Rusli Devi
Published: January 2025

Socialization is one of the human social developments. Social development refers to an individual's ability to behave or act in interactions with social elements in society that meet social demands. The elements of socialization in society include family, friends, school, and mass media. In the school environment, students learn to build relationships with their peers from various family social statuses. To face the problems in the school environment, students must be brave in expressing their feelings and opinions, which is often referred to as assertiveness. This study aims to determine the influence of self-concept on assertiveness in students at SMA Negeri 15 Padang. This research uses a quantitative method. The population in this study consists of 700 students from classes XI and XII at SMA Negeri 15 Padang. Sampling was conducted using purposive sampling with 140 respondents. The study used self-concept and assertiveness scales as measuring instruments. Data analysis was performed using simple regression analysis with IBM SPSS 27. The results of the hypothesis testing showed a significance value (Sig.) of 0.001 < 0.05 with a coefficient of 0.425 and an R Square value of 0.181, indicating that the alternative hypothesis (Ha) is accepted and the null hypothesis (H0) is rejected. This means that there is a positive influence of self-concept on assertiveness among students at SMA Negeri 15 Padang, with an effect size of 18.1%, while the remaining influence is shaped by other factors such as gender, parenting style, culture, and social economic status. In conclusion, the higher the self-concept, the higher the assertiveness.
Level of interest in modular housing in view of survey of real estate professionals
Authors: Bartkowiak Piotr , Koszel Maciej , Pawłowski Łukasz
Published: January 2025

The main purpose of the paper is to assess the level of interest in modular housing in the residential market from the perspective of those involved in the production and sale of houses and apartments manufactured with this technology. The spatial scope of the study covered the Wielkopolskie Voivodeship. The research was conducted in February 2024 using an online survey questionnaire distributed to respondents via email. Three main research questions were posed for the research conducted: (1) What is the level of interest in buying housing manufactured with modular technology? (2) What factors influence the choice of modular technology when buying housing? (3) What is the age of buyers of housing manufactured with modular technology? According to the results obtained young people (aged up to 35) choose modular apartments relatively more often than people over this age. According to respondents, most relevant advantages of this type of technology is that it allows for saving time and construction costs. The research results can be used in the policy of planning and shaping housing in Poland, in the development of entrepreneurship, as well as by people associated with the real estate market. The first of them are developers and producers of modular housing, who can use the results as a source of information for planning subsequent projects. Thus, the study indicates the interest in modular apartments and informs sellers about the key factors that guide consumers when making purchasing decisions. Moreover, using the research conducted, real estate agents can better understand modular technology and offer it to consumers more often. Moreover, results indicate the changing reality of residential market and find out what advantages and disadvantages the modular technology has. This may influence the choice of the best way to meet housing needs and aspirations.
Türkiye'de Belediye Personel Sistemi: Sorunlar ve Çözüm Önerileri
Authors: Yetkin Ozan
Published: January 2025

Yerel yönetimler, bir yerleşim yerinde yaşayan halkın yerel ve ortak nitelikte olan ihtiyaçlarını karşılamak üzere kurulan, karar organları seçimle belirlenen, idarî ve malî özerkliği olan kamu tüzel kişileridir. Türkiye’de “belediye, il özel idaresi ve köy” olmak üzere üç temel yerel yönetim birimi bulunmaktadır. Bu yapı içerisinde başat konumda olan belediyeler, “büyükşehir belediyeleri” ile “büyükşehir dışındaki belediyeler” şeklinde ikiye ayrılmaktadır.
Vatandaşların gündelik hayatına etki eden pek çok kamu hizmeti belediyeler tarafından sunulmaktadır. Bu noktada belediyeler tarafından sunulan kamu hizmetlerinin etkinliği, verimliliği ve kalitesi önem kazanmakta, bu konuda sağlanacak başarı ise büyük ölçüde nitelikli yönetici ve personele bağlı olmaktadır. Bu durum belediye personeli ve belediye personel sistemi konusunun önemini arttırmaktadır.
Bu çalışmada, belediye personel sisteminin sorunları üzerinde durulmakta ve çözüm önerileri üretilmeye çalışılmaktadır. Bu kapsamda ilk olarak 30 büyükşehir belediyesinin faaliyet raporları, stratejik planları, performans programları, personel alım ilanları ve bu belediyelere yönelik Sayıştay denetim raporları incelenmiş ve bulgulara ulaşılmıştır. İkinci aşamada ise büyükşehir belediyelerinde insan kaynakları biriminde yönetici pozisyonunda olan kamu görevlileri ile görüşmeler gerçekleştirilmiştir. Çalışmanın sonuç kısmında her iki yöntemle elde edilen bulgular, belediye personel sisteminin sorun alanları olarak tartışılmış ve çözüm önerileri geliştirilmeye çalışılmıştır.
Implementation of The JKN Program Related to Patient Admission, Medical Data Processing, Reporting and JKN Funding at Murni Teguh Medan Hospital
Authors: Njoto Lina , Nasution Sri Lestari Ramadhani , Girsang Ermi
Published: January 2025

The National Health Insurance Program is an effort made by the government to support comprehensive health development and has the goal of ensuring that the Indonesian population gets their right to health. According to data obtained from BPJS Kesehatan with Murni Teguh Medan Hospital, it was found that the average waiting time for polyclinic services exceeded the national quality indicator, where the waiting time for outpatient treatment did not exceed 60 minutes. Polyclinics for some oncology specialties are still past the expected limits, with Surgical Oncology recording an average wait time of 1 hour 33 minutes, Hematology Oncology reaching 1 hour 49 minutes, and Gynaecological Oncology even reaching 1 hour 58 minutes. The purpose of this study is to analyze the obstacles to the implementation of the JKN program related to patient admission, medical data processing, reporting and JKN funding at Murni Teguh Medan Hospital. This type of research is qualitative descriptive. This study has resource persons as key informants of 3 PICs and supporting informants of 6 staff from the Registration, Medical Records and Billing units of JKN. From the results of the study, it was found that the obstacles in terms of Man: the available human resource registration unit was not in accordance with the qualifications that should have come from medical records, causing several obstacles in the reporting section, Materials.
Gestão de Desempenho Dinâmico e Não Linear nas Linhas de Cuidados Integrais
Authors: Ramalho Andre
Published: January 2025

O editorial aborda a estratégia de gestão de desempenho dinâmico e não linear nas Linhas de Cuidados Integrais, relembrando conceitos que devem ser de apoio para a efetividade dos cuidados nos territórios.
Film watching habits of journalism students from the perspective of the theory of utilities and satisfaction
Authors: Vujović Marija , Obradović Neven
Published: January 2025

Films are the most popular and most visited cultural program in Serbia. According to research by the Institute for the Study o f Cultural Development, the largest audience group in Serbia is the cinema audience. In this paper, film is viewed as a medium, but also as media content, which has its own active audience. The film watching habits o f journalism students at the Faculty o f Philosophy, University o f Niš, are viewed from the perspective o f the theory o f utilities and satisfaction, and the needs whose satisfaction is investigated in this paper are cognitive, affective, personal integrative, social integrative, and the need for releasing tension. The essence o f the theory o f utilities and satisfaction is the transfer o f power from the hands o f senders to the hands o f recipients o f messages. It no longer matters what the sender o f the message wants to achieve, but what benefits and pleasures the recipients o f the media content have. The audience becomes "active", and the premise "what the media does to people" has turned into "whatpeople do to the media". The research was conducted in January 2023 and included 138 journalism students, from all four years o f undergraduate studies. For the purposes o f the research, a special questionnaire was created as a data collection instrument, and the data obtained were processed using the SPSS statistical data processing program. The results o f the research show that watching movies is a frequent activity for journalism students, that they most often watch movies online, on a computer and/or mobile phone, that most journalism students go to the cinema with friends, and that journalism students cite entertainment and socializing with friends, partners or family as the most common reason for going to the cinema. Comedy is the most common film genre that students watch in the cinema, and the opinion o f friends and acquaintances is the most common reason for choosing a film to watch. The results o f the research also show that journalism students satisfy affective needs and tension release needs the most when watching a film, and personal integrative needs the least.
Artificial intelligence, media and journalism: Between a good servant and a bad master
Authors: Tomić Boban , Bajić Predrag
Published: January 2025

The increasingly rapid development o f tools and capabilities provided by generative artificial intelligence is influencing media and journalistic practices, with tendencies towards a drastic transformation o f media structures, and even entire media ecosystems. The use o f generative artificial intelligence tools in media production, as well as in other related professions, can bring significant benefits to the process of data collection, processing, fact-checking, technical refinement o f text, creating headline blocks, and other segments. It can also assist in generating and promoting pre-created authentic journalistic content on social media. However, it is crucial to always keep in mind that behind everything is human input, meaning that artificial intelligence is not the creator o f something entirely new but a processor based on available data and information previously stored by humans in online systems, emphasizing the ongoing essential role o f humans in these processes. On the other hand, there are limitations and potential dangers concerning the infinite possibilities o f misuse o f artificial intelligence, necessitating a more thorough regulatory framework to govern this area. This is not only due to the potential danger o f artificial intelligence surpassing humans but generally to establish order in a new human practice that exceeds previous potentials and capacities. Therefore, it is necessary to address ethical, regulatory, and self-regulatory issues, as well as media literacy.
Local media reporting and influence on political communication in the North of Kosovo and Metohija
Authors: Jakšić Teodora , Marjanović Milica
Published: January 2025

The influence of the media on the formation of public opinion is undeniable, regardless of which sphere of social and public importance is in focus. The political theory sees public opinion as a phenomenon of political practice essential for political activities, which was emphasized by some of our theoreticians (e.g. T. Đorđević). What is new in this work is the analysis of social structures in the areas that were covered by war events and in which we have a permanent state of frozen conflict. The text presents the results of empirical research among students of the University of Pristina with a temporary seat in Kosovska Mitrovica. The aim was to determine the influence of local media in the Serbian language from the North of Kosovo and Metohija in creating public opinion, the degree of trust in media reporting, as well as the existence of cooperation between political activists and professional communicators. The research method was applied, along with interview and survey techniques. Journalists from media companies in the municipalities of Kosovska Mitrovica and Zvečan were interviewed, and a total of 200 students from each faculty of the University of Pristina were surveyed. The sample is random according to the "snowball sampling" technique. The initial hypothesis was that there is a low level of cooperation and trust in reporting between representatives of local political parties and the media.
Analysis of the development of China's long-term care system
Authors: Čen Mengsuan
Published: January 2025

China is entering a stage of rapid population aging. Due to its large population base and the one-child policy implemented for over 30 years, the country is aging faster than most others, with a higher number of elderly people and more pressing elderly care challenges. Traditional home care is no longer sustainable, which increases the need for long-term care. China began exploring long-term care with the introduction of the "Long-Term Medical Care Insurance System" in Qingdao in 2012. In 2016, pilot cities were initiated in 15 regions, expanding to 49 cities in September 2020 following a directive issued for further expansion. However, there is still no unified long-term care system at the national level, and no long-term care law has been established to provide a legal safeguard. Although everyone may eventually require long-term care, given the current coverage of China's longterm care system, this paper focuses on the elderly. The purpose of this paper is to review the development and problems of China's long-term care system over the past ten years. It will address two questions: What is the current status of China's long-term care, and what are the concerns surrounding its long-term care system?
Silent enemy of the hand: The Viking disease
Authors: Stoiljković Vera
Published: January 2025

Dupuytren's contracture (DK) is the most common progressive idiopathic fibrosis of the superficial palmar fascia, often asymptomatic at its onset, caused by changes in the palmar aponeurosis, resulting in flexion contractures in the fingers of the hand. The disease has been known since the Viking Age and is present in about 1-2% of the world's population, with a prevalence that rises to about 20% at the age of 65. This paper aims to present current knowledge related to DK. It is more common in Caucasian men, and heredity, which shows variable expression, plays a vital role in its aetiology. The etiopathogenesis of DK is still unclear and includes the formation of collagen nodules, which progress into fibrous bands between the dermis and fascia at pressure points. The diagnosis is most commonly made by clinical examination, and the treatment can be conservative or surgical. Conservative treatment is reserved for patients with mild symptoms and no finger contracture, while surgical treatment, despite frequent recurrences, is still the gold standard in therapy in situations when the contracture limits hand function and/or flexion of the metacarpophalangeal joint ≥30 degrees and/or proximal interphalangeal joint to any degree. New knowledge about the aetiology of DK would significantly contribute to more effective treatment of this relapsing progressive disease.
From an idea to its realization: A new training centre at the institute for emergency medicine Belgrade
Authors: Anđelić Slađana , Čolaković Goran , Pavlović Aleksandar
Published: January 2025

The idea to create a training centre at the Institute for Emergency Medicine Belgrade was conceived at an unofficial meeting between Prim. Dr Goran Čolaković, the Institute for Emergency Medicine in Belgrade (IEM) General Manager; Prof. Dr Sladjana Andjelić, the IEM Education Center Coordinator; and Prof. Dr Aleksandar Pavlović, the initiator and founder of the Center for Simulation at the University of Pristina Faculty of Medicine Pristina based in Kosovska Mitrovica towards the end of 2015. The need to create a training centre stems from the necessity to provide a contemporary approach to education in treating various emergency medical conditions. This vision requires a new spatial and technical structure with modern phantom mannequins (rescue dummies), medical devices, and equipment. Based on the project financed by the European Union and the European Bank for Reconstruction and Development (EBRD), the reconstruction of the IEM building with a 2000m2 training centre began in July 2021. The Centre aims to integrate all medical knowledge and skills necessary to treat emergency medical conditions in realistic scenarios. It will, therefore, have two simulation centres, five training rooms, two rooms containing vehicles and a large amphitheatre and library.
PRELIMINARY ANALYSIS OF THE DIAGNOSTIC VALUE AND MECHANISM OF ACTION OF TGFΒI AND S100A4 IN HEPATOCELLULAR CARCINOMA
Authors: Zhang Yufeng , Zhao Liang , Shu Qinghua , Sha Bowen , Wu Miao
Published: January 2025

Background: To analyze the diagnostic value of transforming growth factor-beta-induced protein (TGFβI) and S100 calcium-binding protein A4 (S100A4) on hepatocellular carcinoma (HCC), and to further explored the effects of TGFβI and S100A4 on ferroptosis in HCC cells. Methods: We retrospectively analyzed 76 patients with HCC admitted to our hospital from October 2022 to June 2023, and detected the differences in the expression of TGFβI and S100A4 in cancerous tissues and paracancerous tissues to analyze their diagnostic and prognostic assessment value for HCC. Additionally, the HCC cell line HepG2 was purchased and transfected with TGFβI and S100A4 abnormal expression plasmids to check changes in cell viability, oxidative stress damage, mitochondrial damage, and ferroptosis. Results: TGFβI and S100A4 were upregulated in HCC tissues (P<0.05), and their combined detection exhibited excellent diagnostic effects for HCC. The levels of TGFβI and S100A4 in patients who died prognostically were higher than those in surviving patients (P<0.05). An increase in the levels of TGFβI and S100A4 indicates an elevated risk of prognostic death in patients. In cell experiments, upregulating TGFβI and S100A4 expression activated HepG2 activity, inhibited apoptosis, mitochondrial and oxidative stress damage, and improved cell ferroptosis. Conclusions: TGFβI and S100A4 are elevated in HCC and they have the potential to be clinical diagnostic indicators of HCC.
A contribution to the study of the sacral topography of medieval Belgrade: Archaeological and geophysical perspectives
Authors: Bikić Vesna , Pavlović Marina , Vojvodić Uglješa , Ropkić-Đorđević Antonija , Šil Hanes , Točnig Ralf , Bistrović Ivan
Published: January 2025

Returning to the studies of the topography of the Belgrade Fortress from the perspective of archaeological and geophysical research unveiled a number of valuable insights regarding the structure and chronology of constructions within the spatial unit of the Lower Town. In the light of the newly obtained precise layouts of the objects, and harking back to the indicative narrative sources, a reexamination of the available artistic and archaeological material was undertaken. In addition to the confirmation of the presumed position of the Metropolitan Church of the Assumption, new light is shed on the siting of the Franciscan monastery of St. Mary. Based on the features of the floor plan, a possible period of establishment of the Franciscan church and monastery complex in the late 13th or early 14th century, shortly after the first mention of the presence of their community in Belgrade, is considered. Erected in its immediate vicinity was a caravanserai, a building of massive architectural proportions, with an atrium courtyard surrounded by rows of relatively spacious rooms. Its remains were partly destroyed by the construction of infantry barracks by the Austrians (1723-1739), while later, after 1740, Hasan Pasha's mosque was built over the remains of both voluminous buildings.
Urban heritage: The Sunca settlement in New Belgrade
Authors: Mecanov Dragana
Published: January 2025

The aim of the paper is to investigate the urban heritage of the Sunce (Sun) settlement in New Belgrade. A historical methodology was applied to the work. Alongside background research of previous literature and materials related to the topic of the Sunce settlement, the research was divided into four large units, each of which contribute to an understanding of the urban heritage. The four research perspectives (theoretical, urban, architectural and ecological) overlap and complement one another, evidencing the complexity of the situation in which Sunce finds itself, half a century after its construction, in a completely altered context in terms of its relationship to public space. Higher-order plans were also studied, as well as the competition for Blocks 45 and 70, on the basis of which the Sunce settlement was designed and implemented. The architecture itself is investigated, alongside the applied design principles of the Belgrade School of Housing. Through the research of theoretical ideas on urbanism, from Hilbersheimer to Van Eyck, it is recognized that structuralism is the most dominant principle championed throughout the planning of the Sunce settlement. The hierarchy of public spaces and the creation of cohesive centers is considered both an authentic element and the greatest attribute of the planning and design strategy, as well as a major urban characteristic of the Sunce blocks.
Increase of soybean yield using aqueous extracts from plant material
Authors: Đukić Vojin , Miladinović Jegor , Mamlić Zlatica , Đorđević Vuk , Latković Dragana , Ćeran Marina , Bajagić Marija
Published: January 2025

Fertilizer application is requirement for achieving high and stable, economically justified soybean products. Foliar application of aqueous extracts from plant material had a positive effect on soybean yield in both observed years. The lowest soybean yields were on the control variant, which is statistically significantly lower in comparison to other variants of foliar fertilization of soybean. Foliar application of banana peel aqueous extract increased soybean yield by 23.46%, foliar application of banana fruit aqueous extract increased soybean yield by 21.06%, and foliar application of nettle aqueous extract by 18.96%. Compared to the water-treated test variant, foliar application of aqueous extract of banana peel increased soybean yield by 16.80%, foliar application of aqueous extract of banana fruit increased soybean yield by 14.54%, and foliar application of aqueous extract of nettle by 12.55%.
Violent behaviour during sports event or public gathering: Disscutable questions in doctrine and court practice
Authors: Marjanović Đorđe
Published: January 2025

In the Criminal Code of the Republic of Serbia, the Serbian lawmaker prescribed the crime of violent behavior during sports events or other public gatherings in the group of criminal offenses against public peace and order. The subject of this work research, which the author analyzes for the purpose of clarifying all perceived dilemmas in the doctrine and domestic judicial practice. In the first part of the paper, the author points out that there was a disagreement bet ween criminal law doctrine and court practice regarding the issue of the place of execution of the crime, as well as the possibility of athletes and other mandatory participants of the sports event being its perpetrators. The author analyzes the emergent forms of the act as well as the di lemmas in their interpretation, showing a large number of unpublished court judgments made in the past ten years in which the defendants were athletes. In the second part of the paper, the author points to the challenge faced by the subjects of the application of norms when distinguishing bet ween the criminal offense of violent behavior at a sports event and the misdemeanors provided for in the Law on Prevention of Violence and Misbehavior at Sports Events. The author points out that the distinction is important especially if the perpetrators are professional athletes, sports experts and experts in the field of sports, and in terms of possible labor law consequences if a criminal offense was committed and not a misdemeanor. In the third part of the paper, the author analyzes the position of the article of the Criminal Code in which violent behavior during sports events or other public gatherings is criminalized, and which obligates the courts to impose the security measure of prohibition from attending certain sports events on the perpetrators of this act at sports events. In this part, the questions of the justification of the mandatory imposition of the measure are analyzed, as well as the validity of the decision to impose the measure on all persons. The author concludes that the perpetrators of the criminal act of violent behavior at sports events or other public gatherings can be athletes, that the legislator should make an effort to specify certain concepts from the legal description of the act, such as the concept of a sports event, that is, in demarcating the actions of committing a criminal act from misdemeanors that can be committed by violent behavior at a sports event, as well as that it is necessary to make the imposition of a security measure prohibition from attending at sports events optional.
Grade students attending classes in primary schools and at gymnasiums at national mathematics competitions
Authors: Vulović Nenad , Milenković Aleksandar , Milikić Milan
Published: January 2025

For decades, mathematics education researchers have been focusing on students with special abilities in mathematics and mathematics competitions, and examining the impact of various organizational forms of work, such as grouping students and enriching teaching and learning programs, on students' success in competitions. Considering the lack of similar research in the Republic of Serbia, as well as the tradition of grouping students with special abilities in mathematics into specialized (SM) classes, this study aimed to investigate whether there is a trend in the increased participation of SM class students in national competitions and to determine whether there are differences in the achievements of students from SM and regular classes. The research sample consists of all seventh and eighth-grade students who participated in national competitions from 2007 to 2024. The results indicate that there is a trend of increasing the number of SM class students in national competitions, as well as a statistical difference in the achievements of students attending regular and specialized mathematics classes in favor of students grouped in homogeneous (SM) classes. Moreover, over the past 18 years, SM class students have statistically significantly outperformed their peers 11 times in seventh and 12 times in eighth grade. Based on the obtained results, it can be concluded that grouping mathematically gifted students into homogeneous, specialized classes positively affects their performance in national competitions.
Problems in defining the motor space of children
Authors: Šekeljić Goran , Marković Jovan
Published: January 2025

The aim of the study is to define the structure of motor abilities on the selected sample and compare the obtained model with the model determined by nine motor abilities. Testing was performed on a sample of 220 girls and 180 boys aged 10, using a battery of 18 motor tests. Based on the results obtained, factor analysis determined 5 vectors in the boys' group and 4 vectors in the girls' group, carrying the most information about the measured characteristics. For a certain number of variables, it was found that they do not belong to any constituted vector. The results indicate differences in the structure of the motor space between the obtained and tested model; differences in the structure of the motor space between girls and boys; and a greater number of hypothetical models that can explain the structure of the motor space in children. The research results contribute to a better understanding of structural theories in the field of motor abilities; they point out deficiencies in the scientific methodology dealing with the study of motor space and its structure; and indicate the necessity of an interdisciplinary anthropological approach to solve this problem.
Extracción de Reglas en Redes Neuronales Profundas Feedforward Entrenadas: Integración de la Similitud del Coseno y la Lógica para la Explicabilidad
Authors: Negro Pablo , Pons Claudia
Published: January 2025

La explicabilidad es un aspecto fundamental en el campo del aprendizaje automático, en particular para garantizar la transparencia y la confianza en los procesos de toma de decisiones. A medida que aumenta la complejidad de los modelos de aprendizaje automático, la integración de enfoques neuronales y simbólicos ha surgido como una solución prometedora al problema de la explicabilidad. En este contexto, se ha demostrado que la utilización de métodos de búsqueda para la extracción de reglas en redes neuronales profundas entrenadas es eficaz. Esto implica el examen de los valores de ponderación y sesgo generados por la red, normalmente mediante el cálculo de la correlación entre los vectores de ponderación y las salidas. La hipótesis desarrollada en este artículo establece que, al incorporar la similitud de cosenos en este proceso, el espacio de búsqueda se puede reducir de manera eficiente para identificar la ruta crítica que conecta las entradas con los resultados. Además, para proporcionar una comprensión más completa e interpretable del proceso de toma de decisiones, este artículo propone la integración de la lógica de primer orden (FOL) en el proceso de extracción de reglas. Aprovechando la similitud coseno y la FOL, se diseñó e implementó un algoritmo innovador que es capaz de extraer y explicar los patrones de reglas aprendidos por una red neuronal entrenada feedforward. El algoritmo se probó en tres casos de uso y demostró su eficacia a la hora de proporcionar información sobre el comportamiento del modelo.
Pola Pengembangan Paragraf Pada Majalah Neotech
Authors: Julpandi Julpandi , Gunawan Kristian , Fauzi Fikri , Kurniawan Eva Dwi
Published: January 2025

This research examines paragraph development patterns in the text of the July 2001 edition of Neotech Magazine using qualitative descriptive methods. Data was obtained through documentation studies and note-taking techniques, with a focus on analyzing the structure and linguistic elements of paragraphs. The research results identified five dominant paragraph development patterns: chronology, illustration, definition, comparison, and cause and effect. The chronology pattern is used to show the time sequence in technological development, the illustration pattern provides a concrete picture of technological concepts, the definition pattern explains technical terms, the comparison pattern contrasts various technologies, and the cause-and-effect pattern explains causal relationships in technological development. The use of these patterns helps writers convey technology information effectively to readers, with each pattern having a specific function in increasing reader understanding. This research contributes to the development of more effective technology text writing strategies and can be used as a reference in technology journalistic writing.
Developed Algorithm for Optimization of Critical Parts of Technical Systems in the Process Industry
Authors: Brankovic Dejan , Milovanovic Zdravko
Published: January 2025

Maintenance, as an integral part of the production process, plays a major role in ensuring optimal conditions in which the production process is carried out. The paper presents an example of the optimization of a part of the technical system of a paper machine, an industrial plant for the production of hygienic paper, with the aim of increasing the degree of reliability and reducing total maintenance costs. The starting point for the modernization of part of the production system is the setting up of an optimization algorithm for critical parts of technical systems, the application of which should result in concrete positive effects in the maintenance and production sector. The model considered the criticality analysis of parts of the technical system from the point of view of maintenance, as well as the analysis of technological parameters that have the potential to achieve savings by reducing energy consumption in the technological process. The most significant positive result of the optimization is the reduction of energy consumption per unit of produced goods, which is certainly a priority goal today, given the high costs and unavailability of certain energy sources.
El cromo: un tóxico para la salud humana
Authors: Garzón Raygoza Nancy Lorena , Bojórquez Sánchez Carolina , Osuna Martínez Carmen Cristina , Delgado Alvarez Carolina G. , Escobar Sánchez Ofelia , Aguilar Juárez Marisela , Frías Espericueta Martín Gabriel
Published: January 2025

Potentially toxic elements (PTEs) are a group of chemical compounds that are present in nature as part of the earth's crust in small quantities. Among these PTEs we find the chromium (Cr); which is required for human metabolism. However, this element could affect human health at relative high concentrations. Unfortunately, chromium levels have increased significantly due to the industrial human activities increase; which causes a human health increases in that populations around industrial zones. In this context, the present manuscript is a review regarding the potential human risk by chromium.
Itching Wigs, Fallen Masks
Authors: Steinbeis Maximilian
Published: January 2025

At the End of a Historic Week
Effects of Radiochemotherapy on Muscle Oxygen Saturation in Locally Advanced Lung Cancer Patients
Authors: SAHIN YIlmaz , Zortul Abdulsamet , OZTURK Deniz
Published: January 2025

Objective: This study aimed to investigate the effects of curative radio chemotherapy on muscle oxygen saturation dynamics using the Moxy oxygen monitor in individuals with locally advanced lung cancer. Materials and Methods: A prospective study was conducted at Atatürk University Sports Sciences Application and Research Centre. Male patients aged 30–70 years with a diagnosis of locally advanced lung cancer were recruited from the Radiation Oncology Clinic of Erzurum Regional Training and Research Hospital. Before and after curative radio chemotherapy, participants performed a low-intensity acute aerobic walking exercise protocol on a treadmill for 10 minutes. Muscle oxygen saturation (SmO₂) and total hemoglobin (tHb) levels in the rectus femoris muscle were monitored during and after the test using near infrared spectroscopy with the Moxy monitor. Data were analysed using SPSS 26.0 software. Results: The results demonstrated a significant increase in total hemoglobin values in both the right and left legs following curative radio chemotherapy. Conclusion: Curative radio chemotherapy positively influenced muscle oxygen saturation and total hemoglobin levels, suggesting a potential improvement in muscle oxygenation dynamics in patients with locally advanced lung cancer.