bluuebunny/crossref_metadata_2025 huggingface dataset:
The «submarine crisis» and its possible consequences
Authors:   Institute of Europe of Russian Academy Sciences, Rubinskiy Yuri , Fedorov Sergey ,   Institute of Europe of Russian Academy Sciences
Published: November 2021

The creation of a new military and political bloc AUKUS along with breaching «the contract of the century» for construction of 12 submarines by French Naval Group for Australia provoked a serious diplomatic crisis between France and the United States. The hot phase of the crisis was subdued by a telephone conversation between J. Biden and E. Macron, nevertheless, there are reasons to believe it will not disappear without a trace. The authors analyze possible consequences of the «submarine crisis»: its impact on transatlantic and Franco-American relations, European and Indo-Pacific strategies of Paris.
UK National Security Strategy
Authors:   Institute of Europe of Russian Academy Sciences, Ananieva Elena , Godovanyuk Kira ,   Institute of Europe of Russian Academy Sciences
Published: November 2021

The new UK national security strategy review (March 2021) has an integrated character, for the first time uniting the spheres of defense, security, development and foreign policy in one concept. This paper explores the evolution of the Johnson government approaches to the content of the strategy and its implementation in the context of post-Brexit and its implications for UK-Russia bilateral relations.
Italy grasped by US-China rivalry
Authors:   Institute of Europe of Russian Academy Sciences, Alekseenkova Elena
Published: November 2021

Cooperation of the EU members with China is now under increasing supervision of Washington and Brussels. The growing US-China confrontation direct impacts the relations between the EU and PRC, contributing to the adoption by Brussels of tighter control over investments in strategic sectors of economy. EU member states have to adapt their bilateral relations with China to these new developments. Formed in February 2021, the new Italian government of M. Draghi over the past eight months has nearly completed the reversal in relations with Beijing, questioning not only the memorandum of understanding signed in March 2019, but also tightening the mechanisms of control over investments coming from China.
Common Security: Can It Be Reinvented?
Authors:   Institute of Europe of Russian Academy Sciences, Gromyko Alexey
Published: November 2021

In 2021 it is impossible to neglect the fact that our world is moving in a totally wrong direction. Differences between the United States and China are becoming one of the fundamental elements of major powers' competition. Some experts believe that confrontation between the US and China will result in a new edition of bipolarity. Others maintain that the rivalry between the world's two leading economies is a bilateral conflict and cannot evolve into a bipolar world order similar to that of the Cold War. In any case, US-China military tensions are a major risk. These tensions are a time bomb. There is a real risk of a dangerous escalation over Taiwan.
Multiregion segmentation of microcalcificationin mammogram images by using Parametric Kernel Graph Cut algorithm
Authors:   Faculty of Computer and Mathematical Sciences, Universiti Teknologi MARA Cawangan Negeri Sembilan, 70300 Seremban, Negeri Sembilan, Malaysia, Abdul Malek Aminah , Abdul Rahim Nurhanani ,   Faculty of Computer and Mathematical Sciences, Universiti Teknologi MARA Cawangan Negeri Sembilan, 70300 Seremban, Negeri Sembilan, Malaysia, Mushtafa Nor Farah Nabilah ,   Faculty of Computer and Mathematical Sciences, Universiti Teknologi MARA Cawangan Negeri Sembilan, 70300 Seremban, Negeri Sembilan, Malaysia, Zailan Nadhirah Afiqah ,   Faculty of Computer and Mathematical Sciences, Universiti Teknologi MARA Cawangan Negeri Sembilan, 70300 Seremban, Negeri Sembilan, Malaysia, Mohamed Norlyda ,   Faculty of Computer and Mathematical Sciences, Universiti Teknologi MARA Cawangan Negeri Sembilan, 70300 Seremban, Negeri Sembilan, Malaysia
Published: November 2021

Early detection of breast cancer can be detected through screening mammography. However, the potential abnormality such as microcalcification can hardly be differentiated by the radiologists due to the tiny size, which sometimes be hidden behind the density of breast tissue. Therefore, image segmentation technique is required. This paper proposes the potential use of Parametric Kernel Graph Cut Algorithm in segmenting microcalcification. The performances of this method were measured based on accuracy, sensitivity, Dice and Jaccard coefficient. All the experimental results generated satisfying results, whereby all images produced the average of 91.67% for Dice coefficient and 84.72% for Jaccard coefficient. Meanwhile, both accuracy and sensitivity results acquired 97.84% and 96%, respectively. Therefore, Parametric Kernel Graph Cut algorithm had proved its ability to segment the microcalcification robustly and efficiently.
Web Engagement Strategies In Business, Government And Education Sector: Review
Authors:   Kolej Komuniti Paya Besar, Jalan Maran-Gambang, 26600 Gambang, Pahang, Malaysia., Ahmad Norita , Abdullah Aziman ,   Faculty Of Computing, Universiti Malaysia Pahang, 26600 Pahang, Malaysia
Published: November 2021

Web engagement is a user experience related to emotional, cognitive and behavioural interaction that connect to the goals and interests of the customers. There are seven (7) engagement metrics listed that used to measure web engagement. However, not all of these engagement metrics will help to achieve the objectives because each website have different purpose. There are various web engagement strategies used in business, government and education sectors that has their own way of engaging the web to ensure their success. In business sector, positive communication and experience with customers can make the customers stay long with the brand. In government, most of the services provided are to facilitate the people and to maintain the trust and support of the people. The E-Government 2.0 model was presented with an additional element of Web 2.0 technology. In education, Learning Management System (LMS) and Massive Open Online Courses (MOOCs) are some of the approach in online learning. There are four (4) main features of online learning that are distance learning, connectivity and involvement, support and flexibility control to ensure the continuity of online learning. This reviewing will lead having in attention the aim of developing high-performance in online engagement.
Se-LMS: Secured learning management systems for smart school
Authors:   Department of Computer Science, Federal University of Agriculture Abeokuta, Nigeria., Falana Olorunjube James , Ebo Ife Olalekan ,   Department of Computer Science and Mathematics, Mountain Top University, Ibafo, Nigeria, Odom Ifeanyi Shadrach ,   Department of Computer Science and Mathematics, Mountain Top University, Ibafo, Nigeria
Published: November 2021

One of the research topics that focus on Information Communication Technology in Education is Learning Management System (LMS). LMS is a web-based software application developed to create, manage, and delivered e-learning courses. Many research works have been conducted on different learning options in LMS. However, the increased use of LMS has brought with it the security issues such as the denial of service attack, malware and privacy. In order to protect the different actors of LMS such as students, instructors and controlling authorities, this paper proposes a multi-factor authentication and identity management for securing LMS. Se-LMS is capable of dynamically authenticating users using different methods such as a seamless combination of Oauth2.0 and 2FA or Username/Password and 2FA as proposed. Also, the paper explains the situation and existing research relating to security in Learning Management Systems in smart school. The proposed framework has been applied to cloud-based LMS to show the ability to mitigate an attack.
Improving the Accuracy of Static Source Code Based Software Change Impact Analysis Through Hybrid Techniques: A Review
Authors:   Department of Computer Sciece, Kwara State University, Malete, Kwara State, Nigeria., SHAKIRAT YUSUFF , BAJEH AMOS ,   Department of Computer Science,University of Ilorin, Ilorin, Nigeria., Aro T.O ,   Departmentof Mathematical and Computing Sciences,KolaDaisi University, Ibadan, Oyo State,Nigeria, ADEWOLE KAYODE ,   Department of Computer Science,University of Ilorin, Ilorin, Nigeria.
Published: November 2021

Change is an inevitable phenomenon of life. This inevitability of change in the real world has made a software change an indispensable characteristic of software systems and a fundamental task of software maintenance and evolution. The continuous evolution process of software systems can greatly affect the systems’ quality and reliability if proper mechanisms to manage them are not adequately provided. Therefore, there is a need for automated techniques to effectively make an assessment of proposed software changes that may arise due to bug fixes, technological advancements, changing user requirements etc., before their implementation. Software Change Impact Analysis (CIA) is an essential activity for comprehending and identifying potential change impacts of software changes that can help prevent the system from entering into an erroneous state. Despite the emergence of different CIA techniques, they are yet to reach an optimal level of accuracy desired by software engineers. Consequently, researchers in recent years have come up with hybrid CIA techniques which are a blend of multiple CIA approaches, as a way of improving the accuracy of change impacts analysis techniques. This study presents these hybrid CIA techniques and how they improve accuracy. They are also compared and areas for further research are identified.
Fake news identification
Authors: Racsko Peter
Published: November 2021

Fake news, deceptive information, and conspiracy theories are part of our everyday life. It is really hard to distinguish between false and valid information. As contemporary people receive the majority of information from electronic publications, in many cases fake information can seriously harm people’s health or economic status. This article will analyze the question of how up-to-date information technology can help detect false information. Our proposition is that today we do not have a perfect solution to identify fake news. There are quite a few methods employed for the discrimination of fake and valid information, but none of them is perfect. In our opinion, the reason is not in the weaknesses of the algorithms, but in the underlying human and social aspects.
Ruscogenin alleviates cognitive dysfunction by inhibiting the activation of isoflurane-induced NLRP3 inflammasome in aged mice
Authors: Liang Xiaohu , Luo Xiaoqun , Li Danping , Kong Lingqiong
Published: November 2021

Ruscogenin exerts an anti-inflammatory effect in the pathogenesis of various human diseases, including pulmonary hypertension, acute lung injury, acute pancreatitis and cerebral ischemia. Its role in isoflurane-induced rats with postoperative cognitive dysfunction (POCD) was investigated in this study. Aged rats were exposed to isoflurane for establishing a model of POCD, and administered with ruscogenin by gavage. Cognitive dysfunction was evaluated by the Morris water maze test. Hematoxylin and Eosin (H&E) staining was designed to assess neuronal damage. Markers of brain damage and neuroinflammation were detected by enzyme-linked-immunosorbent serologic assay. Isoflurane exposure caused impaired cognitive function by increasing escape latency, decreasing the time taken for crossing target and time in target quadrant. However, administration of ruscogenin reversed these cognitive dysfunctions. Abnormal morphological phenomena on neurons and enhanced levels of serum calcium-binding protein β (S-100β) and neuron-specific enolase (NSE) were identified in mice post-isoflurane exposure. Administration of ruscogenin ameliorated the neuronal morphological damages and reduced the levels of S-100β and NSE in the hippocampi of isoflurane-induced aged mice. Ruscogenin also attenuated isoflurane-induced enhancements in the levels of Interleukin (IL)-1β, IL-6 and tumor necrosis factor-alpha in the hippocampi of mice. Isoflurane-induced enhancements in the mRNA expression levels of NLR family pyrin domain containing 3 (NLRP3), ASC, IL-1β and IL-18 proteins were also restored by administration of ruscogenin. Ruscogenin exerted neuroprotective effects against isoflurane-induced cognitive dysfunction and neuroinflammation through blocking of NLRP3 pathway.
Juglanin alleviates myocardial injury in rats with acute myocardial infarction through modulating MAPK signaling pathway
Authors: Sun Jing , Song Lei
Published: November 2021

The aim of this study was to investigate the protective role of Juglanin in rats suffering from acute myocardial infarction (AMI). Male Sprague–Dawley (SD) mice were used to construct the AMI model. Hematoxylin and Eosin staining was used to observe the morphological changes of cardiomyocytes. Changes in lactate dehydrogenase (LDH), caspase-3 and caspase-9 were measured using commercial kits. Enzyme-linked immunosorbent assay was used to measure the serum level of creatine kinase myocardial band (CK-MB), Interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), IL-10 and IL-1β. Protein expression and phosphorylation were determined by Western blotting test. The morphology of cardiomyocytes suffered great changes because of AMI, which included focal myocardial necrosis, severe inflammatory cell infiltration, and myocardial fiber dissolution, disorder, and partial rupture. The morphological changes in cardiomyocytes were significantly ameliorated through treatment with Juglanin (10 mg/kg and 30 mg/kg). Increment of serum CK-MB, LDH, IL-6, TNF-α, IL-10 and IL-1β was reduced in AMI rats treated with 10-mg/kg and 30-mg/kg Juglanin. Cell apoptosis was also inhibited by Juglanin treatment. AMI-induced phosphorylation of p38, extracellular signal-regulated kinase (p-ERK) and c-Jun N-terminal kinase (p-JNK) was suppressed through treatment with Juglanin. This study demonstrated that Juglanin alleviated myocardial injury in rats because of AMI through inactivation of mitogen-activated protein kinase signaling pathway, thus indicating a protective role in rat AMI model.
Coinoculaton of endophytic diazotroph with PGPR and AM fungi for enhancing sugarcane production
Authors: Jamuna E. , Thiruvarassan S. , Sridhar P.
Published: November 2021

The field experiment was conducted at Sugarcane Research Station, Cuddalore during 2010 – 2012, to evaluate the response of sugarcane variety CoC 24 to the application of bioinoculants viz., Gluconoacetobacter diazotrophicus, AM fungi and Azophos (Azospirillum and phosphobacteria), under different levels of N, P2O5 and K2O inorganic fertilizer in plant and ratoon crop. The results revealed that the application of mycorrhizae, G. diazotrophicus, Azospirillum and phosphobacteria significantly produced higher cane yield in plant crop. The application of Gluconoacetobacter diazotrophicus @10 kg + AM fungi + Azophos @10 kg + 75 % NPK recorded the maximum germination and tiller population and also maximum mean millable cane population of 1.32 lakhs /ha, cane yield (137.45 t/ha) and sugar yield (16.96 t/ha). Similar results were recorded with the ratoon crop. The population of Azospirillum and Pseudomonas are higher compared to that of Glucanoacetobacter diazotrophicus and phosphobacteria. The application of bioinoculants improves soil microbial biomass and their by enhancing soil organic matter content. The applied bacterial sources helps in nitrogen fixation and also in continuous mobilizing and solubilisation of nutrients and their persistence and colonization in soil is an added advantage and also enhances the soil fertility. The usage of these bioinoculants inturn reduces the inorganic fertilizer input and thereby reduces the cost of cultivation.
Impact of integrated weed management on growth, yield and economics of onion (Allium cepa L.)
Authors: Tyagi S. K. , Kulmi G. S. , Khire A. R.
Published: November 2021

An experiment was conducted in the Rabi season of two consecutive years of 2019-20 and 2020-21, respectively to determine find out practically convenient and economic weed control measure for the onion growers. Treatments comprised T1 Farmers’ practice (pendimethalin 30% EC 1 kg ai/ha before transplanting+ 1HW at 25 DAT) and T2 (oxyflurofen 23.5% EC @ 0.10 kg ai/ha + quizalofop ethyl 5% EC @ 0.05 kg ai/ha at 25 DAT + 1 HW at 45 DAT) replicated at ten farmers’ field. Treatment T2 (oxyflurofen 23.5% EC @ 0.10 kg ai/ha + quizalofop ethyl 5% EC @ 0.05 kg ai/ha at 25 DAT + 1 HW at 45 DAT) recorded significantly lowest weed density (32.59/m2), highest plant height (52.50 cm), neck thickness (1.12 cm),bulb diameter (6.38 cm), bulb weight (92.57 g) and bulb yield (304.85 q/ha) as compared to treatment T1. The highest net returns (Rs 2,04,391/ha) and B:C (3.04) were obtained with T2.
Assessing efficiency of seed hardening treatments in blackgram
Authors: Parameswari K. , Sangeetha S. , Vijayageetha V.
Published: November 2021

Seed is a biological entity and its quality is improved through seed hardening. Seed hardening is a simple method to alter the physiological and biochemical nature of the seeds. Any successful technology could be performed well in farmer field and their feedback will be helpful for fine tuning of the technology. On farm trial was conducted in farmers field with two seed hardening treatments viz., (i) Seed hardening with Zinc sulphate @ 0.1g/lit for 3 hr and (ii) Seed hardening with Sodium molybdate @ 0.5g/lit for 3 hr along with untreated seeds as a control during Rabi, 2017-18. The results revealed that seed hardening with Sodium molybdate @ 0.5g/lit performed better interms of yield (678 kg/ha), net return (Rs.23,125/ ha) and benefit cost ratio (1.81) compared to seed hardening with Zinc sulphate @ 0.1g/lit and control and which was 669 kg/ha, Rs.21913/ha, 1.77 and 514 kg/ha, Rs.12159 /ha, 1.45, respectively. However, the minimum yield difference was observed between the seed hardening treatments but both seed hardening treatment were excelled over the control. Hence, seed hardening with Sodium molybdate @ 0.5g/lit or Zinc sulphate @ 0.1g/lit for 3 hr found effective in increasing the yield in blackgram. The knowledge level of farmers on seed hardening treatments increased from 13 to 70 per cent which was made through on farm testing programme.
Impact of integrated weed management practices soil microbial count and grain yield in black gram (Phaseolus mungo L.)
Authors: Bholane J. P. , Rajput Kavita D. , Bhale V.M.
Published: November 2021

A field investigation was carried out during Kharif season in 2010 at Agronomy Department Farm, Dr.Panjabrao Deshmukh Krishi Vidyapeeth, Akola, to evaluate the effect of four herbicides (imazethapyr, pendimethalin, fenoxyprop-p-ethyl and quizalofop -p-ethyl ) applied at different rates with different time of application (pre-emergence,post emergence and combination of both) and cultural practices on soil microflora and yield of black gram (Phaseolus mungo). Data revealed that different chemicals and cultural weed control practices were exhibited their superiority over weedy check and reduced the crop weed competition by controlling the annual and broad leaved weeds. Among all the weed control treatments, pre-emergence application of pendimethalin @ 1.5 kg/ha showed higher yield per ha (10.05) and in case of in microbial study, bacterial, fungal and actinomycetes count before spraying of herbicide was non-significant but microbial count was reduced after spraying of herbicides as compared to before spraying of herbicides,as a result(before and after spraying of herbicide) pre-emergence application of imazethapyr at 75 g ha-1[(25.11, 17.10 ) ,( 19.50, 10.84) and (22.30,16.10)] showed the lower microbial count. In case of weedy check(26.90, 20.60 and 23.98) showed maximum microbial count followed by weed free (26.50, 20.30 and 22.60 ), among all the weed control practices.
Indian oilseed sector : Need for self-sufficiency in oilseed production
Authors: Singh Rajkaranbir
Published: November 2021

Oil crops are an ideal component in the sustainable production system in Indian agriculture. But, the area under oilseeds has experienced a deceleration in general, due to their relative lower profitability against competing crops like maize, cotton, chickpea, etc. under the prevailing crop growing and marketing situations. Despite being the fifth largest oilseed crop producing country in the world, India is also one of the largest importers of vegetable oils today. The country now imports nearly 60 per cent of the annual consumption of 259.22 million tonnes. However, increasing demand for edible oils necessitated the imports in large quantities leading to a substantial drain on foreign exchange. Edible oil consumption in the country has been consistently rising faster than production due to growth in population, increasing income levels and the emerging dietary changes are driving increasing use of edible oils. An immediate action towards this sector is utmost required or the dependency on import will certainly increase in the days to come due to mushrooming population and increased per capita consumption. It is, therefore, necessary to exploit domestic resources to maximize production to ensure edible oil security for the country.
Impact of integrated weed management on yield and economics of Kharif maize (Zea mays L.)
Authors: Bade A. S. , Patil J. B. , Gajbhiye P. N. , Sarwar I. , Yadav Kiran
Published: November 2021

A field experiment conducted to evaluate the impact of integrated weed management on economics of Kharif maize (Zea mays L.) during Kharif, 2020 at Post Graduate Research Farm, RCSM College of Agriculture, Kolhapur. The field experiment was laid out in Randomized Block Design (RBD) having eight treatments replicated thrice.Weed free check and tank mixure application of Tembotrinone 42 SC @ 120gm a.i.ha-1 + Atrazine 50 WP @ 500 gm a.i.ha-1 + surfactant @ 2ml/l of water EPoE At 20-25 DAS + fb hand weeding at 40 DAS were on par with each other and recorded significantly increase in grain and straw yields of maize as compared to remaining weed management treatments. Significantly lowest values for yield and yield attributes was observed in weedy check treatment.Maximum gross monetary returns and net monetary returns were observed in weed free check treatment was Rs. 183225.5 ha-1 and Rs. 126320.7 ha-1, respectively. Tank mixure application of Tembotrinone 42 SC @ 120gm a.i.ha-1 + Atrazine 50 WP @ 500 gm a.i.ha-1 + surfactant @ 2ml/l of water EPoE At 20-25 DAS recorded maximum B: C ratio (3.34).
Scope and future perspectives of phytoremediation
Authors: Tallapragada Sridevi , Lather Rajesh , Vandana  , Singh Gurnam
Published: November 2021

Phytoremediation is the plant-based technology that has emerged as a novel cost effective and ecofriendly technology in which green plants are used for extraction, sequestration and/or detoxification of the pollutants. Plants possess the natural ability to degrade heavy metals and this property of plants to detoxify contaminants can be used by genetic engineering approach. Currently, the quality of soil and water has degraded considerably due heavy metal accumulation through discharge of industrial, agricultural and domestic waste. Heavy metal pollution is a global concern and a major health threat worldwide. They are toxic, and can damage living organisms even at low concentrations and tend to accumulate in the food chain. The most common heavy metal contaminants are: As, Cd, Cr, Cu, Hg, Pb and Zn. High levels of metals in soil can be phytotoxic, leading to poor plant growth and soil cover due to metal toxicity and can lead to metal mobilization in runoff water and thus have a negative impact on the whole ecosystem. Phytoremediation is a green strategy that uses hyperaccumulator plants and their rhizospheric micro-organisms to stabilize, transfer or degrade pollutants in soil, water and environment. Mechanisms used to remediate contaminated soil includes phytoextraction, phytostabilization, phytotransformation, phytostimulation, phytovolatilization and rhizofiltration. Traditional phytoremediation method presents some limitations regarding their applications at large scale, so the application of genetic engineering approaches such as transgenic transformation, nanoparticles addition and phytoremediation assisted with phytohormones, plant growth-promoting bacteria and Arbuscular mycorrhizal fungi (AMF) inoculation has been applied to ameliorate the efficacy of plants for heavy metals decontamination. In this review, some recent innovative technologies for improving phytoremediation and heavy metals toxicity and their depollution procedures are highlighted.
Drought stress and its impact on plant mechanism
Authors: Tiwari Anjali , Punetha Shailaja , Kesarvani Kapil
Published: November 2021

Drought is one the most common adverse environmental problem is increasing as a result of increasing population of world and intensive use of natural resources. Drought stress has major constraints to agricultural productivity worldwide, particularly in warm, arid and semi-arid areas. It adversely affects plants Morphological, Physiological and Biochemical processes and prolonged drought stress limits plant growth and productivity. The effect of drought stress at a whole plant level results non-normal physiological process that impact one or a combination of biological and environmental factors. That is why this review paper is mainly focused on recent information about the influence of water stress on plants, as well as its mechanisms of adaptation. It is shown that plants have evolved physiological and biochemical adaptations to cope with water stress. Plant used molecular mechanism to increase tolerance against drought are discussed. The literature analysed in this review shows an understanding of how these systems are regulated and upgrade the effect of drought stress on plants mechanism. The provided information needed to improve plants tolerance against drought stress by using biotechnological tools.
Theater Reform and the Masque in Marvell's Upon Appleton House
Authors: Laam Kevin
Published: November 2021

The signature scene shifts, pastoral settings, and perspectival instabilities of Andrew Marvell’s Upon Appleton House squarely align the poem with the theatrical tradition of the court masque, a tradition that was effectively moribund at the at the time of the poem’s composition in 1651.  The influence of the masque on Upon Appleton House (and other Marvell works) has been widely noted, but the significance of his poem in the longer history of English theater—specifically, in the discourse of theatrical reform—has not been fully considered.  In Upon Appleton House, Marvell not only applies the strategies and techniques of the masque, but he also engages with ideas central to the ongoing debate between opponents and defenders of the stage.  As such, his poem anticipates the reforms and innovations attempted by William Davenant, Richard Flecknoe, and others who campaigned to revive theater in Interregnum England.  However, Marvell’s appropriation of masque theatrics is not tethered to the goals of reform.  His poem is distinctly the product of the post-regicide, pre-Protectorate imagination, when the theaters are shuttered, dramatic performance is driven underground, and the fate of the Commonwealth is precarious.  Accordingly, his method is not to establish a mode of theater palatable to republican interests, but instead to defamiliarize theatrical representation in a way that responds to the uncertainty of the moment.
Análisis del clima urbano por teledetección en el Altiplano peruano
Authors: Quispe Diana Karen Pari , Silva Joára Cronemberger Ribeiro , Silva Caio Frederico e
Published: November 2021

El altiplano Sudamericano es una amplia planicie situada a 3800 metros sobre el nivel del mar, se caracteriza por tener bajas temperaturas sobre todo en los meses más fríos con grandes amplitudes térmicas diarias pudiendo llegar por debajo de los 0°C. Este artículo propone el análisis del clima urbano por el método de teledetección a través de QGIS y la calculadora ráster para determinar la temperatura superficial y radiación solar en un sector de viviendas sociales existentes asentadas a orillas del lago Titicaca. Los resultados indican que temperatura superficial para el mes de julio del 2019 varia de 14,63 °C a 18,95 °C y la radiación en el área de estudio es de 706 W/m2. Con ello se señala factores que influyen en el microclima urbano, así como la ventaja solar presente en el contexto Andino.
Confort térmico en viviendas sociales en la zona Mesoandina de Perú – soluciones para mejorar la calefacción pasiva usando materiales autóctonos
Authors: Quispe Diana Karen Pari , Silva Joára Cronemberger Ribeiro , Silva Caio Frederico e
Published: November 2021

La zona Mesoandina peruana va desde los 3500 a 4000 metros sobre el nivel del mar, se caracteriza por tener viviendas sin sistemas de calefacción y el uso de materiales de construcción convencionales sin protección térmica. La Totora, una planta acuática que crece en el Lago Titicaca a 12,500 pies (3810 metros sobre el nivel del mar), constituye un material disponible y económico. Este articulo propone soluciones de acondicionamiento térmico con materiales autóctonos como laTotora para incrementar el confort en viviendas sociales existentes tomando como caso la Ciudad de Puno a orillas del lago Titicaca, por medio de estrategias pasivas de calentamiento y haciendo uso de simulaciones termoenergéticas con la herramienta Design Builder versión 6.1.0. Los resultados obtenidos indican que con las soluciones de acondicionamiento pasivo se logra un 50.0% al 58.3% de porcentaje de horas ocupadas en confort (POC) para el día típico de invierno. La combinación EnTI_3 alcanzan un incremento en promedio para los ambientes estudiados de la temperatura operativa en 7.6 °C con respecto a su estado actual. Con ello se pone de manifiesto la importancia del empleo de la calefacción solar en relación directa con el desempeño térmico de las viviendas sociales estudiadas.
Kırklareli Kavaklımeşe Korusu Tabiat Parkının rekreasyon potansiyelinin belirlenmesi
Authors: ASLAN Fürüzan , ATEŞ Oğuz , BÜYÜKBAYRAKTAR Nehar , KABATAŞ Engin
Published: November 2021

Bu araştırmada Kırklareli ilinde bulunan Kırklareli Kavaklımeşe Korusu Tabiat Parkı’nın rekreasyon potansiyelinin belirlenmesi amaçlanmıştır. Rekreasyon potansiyelinin belirlenebilmesi için ülkemizdeki pek çok çalışmada kullanılmış Gülez yönteminden yararlanılmıştır. Çalışma alanına 2020 yılı Eylül, 2021 yılı Mayıs ve Haziran aylarında 4 hafta içi ve 5 hafta sonu olmak üzere toplamda 9 kere gidilmiş ve yerinde gözlemler yapılarak rekreasyon potansiyeli belirlenmeye çalışılmıştır. Araştırma sonucunda Kırklareli Kavaklımeşe Korusu Tabiat Parkı’nın rekreasyon potansiyelinin %59 (orta düzey) olduğu ortaya konmuştur. Alanda bulunan yapı ve tesisler iyileştirilerek, rekreatif kolaylıklar arttırılarak, olumsuz etmenler giderilerek Kırklareli Kavaklımeşe Korusu Tabiat Parkı’nın rekreasyon potansiyelinin arttırılabileceği sonucuna ulaşılmıştır.
617.1 URMC HTC BSL2+ Non-Inflated Fresh-Frozen Embedded Lung and Associated Tissue v1
Authors: S Pryhuber Gloria , Huyck Heidie , Rogers Lisa , Poole Cory
Published: November 2021

Purpose and Scope of the Procedure - Safe work with unfixed potentially or known SARS CoV2 / COVID-19+ infected tissue - Rapid blocking, embedding and freezing of human lung tissue in no freezing media, 100% OCT or 5% CMC - Rapid freezing of non-lung tissue in no freezing media, 100% OCT or 5% CMC
Research on low birth weight v1
Authors: Wang Jun
Published: November 2021

An low-birth-weight model was established with malnutrition during pregnancy. The machanism of LBW underlying in adult diseases was explored.
Kinovea tracking guide and distance calculationR script v1
Authors: Benmaamar Simon
Published: November 2021

This protocol can be used to determine the travelled distances of larvae on a black-stained agar plate. For this purpose, videos of the moving animals are recorded, the movement is then tracked using the Kinovea program and the resulting files are evaluated using an R script.
Cluster approach to organization of genomic research
Authors: Volkova N. S. , Putilo N. V.
Published: November 2021

The accelerated development of genetic technologies in the Russian Federation and their consistent use in health care, agriculture and industry for full implementation require the availability of effective organizational tools that allow not only to develop new genomic technologies but also their practical application. The article explores the legal aspects of the functioning of medical and pharmaceutical clusters; analyzes the possibilities of using a cluster approach to the organization of genomic research; it is stated that the advantage of the cluster is the concentration in a small territory of interconnected scientific organizations, educational institutions and innovative industries.
Methological aspets of assessing the quality of medical care
Authors: Kolokolov A. V.
Published: November 2021

One of the most urgent areas of Russian health care is the organization of medical care in the new socio-economic conditions, aimed at providing affordable high-quality and safe medical care to the population, therefore, a new approach to the formation of control over both the quality of medical care and its safety is of particular interest. At all stages of the treatment and diagnostic process, serious mistakes can be made that can have a negative impact on the life and health of patients.The article discusses the methodological aspects of assessing the quality of medical care at all stages of the treatment and diagnostic process. Requirements for the formation of an expert opinion, which is prepared based on the results of the examination of the quality of medical care, have been formulated. In order to effectively manage the quality of medical care, the author proposes the creation of a digital “smart” system for monitoring defects in medical care.
Gene doping and bioethics: legal regulation. Prospects, forecasts, obstacles
Authors: Shevchenko O. A.
Published: November 2021

The article analyzes the correlation between the development of genetic science and bioethics issues. In the context of the rapid and steady development of genetic engineering and biomedicine, there is a lag in legal research in this area. Determining the vector of development of legal regulation of gene therapy and gene doping is currently one of the most important issues of modern science, which needs to be resolved from a legal and ethical point of view. In regulatory legal acts in the field of international sports and at the national level, a ban on the use of gene doping has been established, as well as responsibility for its use is provided. However, the measures taken are not enough.The article considers some existing problematic aspects of the correlation between the development of genetic science and bioethics and suggests ways to solve them. Thus, it is proposed to build a system of principles for preventing and countering the use of the gene doping method and to differentiate the concepts of gene therapy and gene doping in order to comply with the principles of Olympism and preserve the health of future generations.
Legal means of protecting the rights to the results of intellectual activities in healthcare in international business
Authors: Sushkova O. V.
Published: November 2021

The author analyzes the legal means of protecting the rights to the results of intellectual activity through the TRIPS agreement and its impact on the development of international business in the field of healthcare. Attention is paid to the national patent policies of different legal orders, exploring the theoretical differences in the policies of different countries. It also addresses key domestic implementation policy issues as the new rules move from the international to the national level. Finally, it examines the implications of TRIPS for managing innovation in ICT-based industries, including pharmaceuticals, and where ICT has enabled global value chains, where the speed and distributed nature of innovation makes intellectual outcomes both less efficient and more necessary
Violation of sanitary and epidemiological rules: issues of criminalization and legislative regulation
Authors: Norvartyan Yu. S.
Published: November 2021

The article discusses some problems of criminalization and lawmaking in the field of countering crimes involving violations of sanitary and epidemiological rules. From the point of view of the legal and technical approach, Part 1 of Article 236 of the Criminal Code of the Russian Federation contains a construction of a complex composition, which can be called «delinquent-material». In such a composition there is both a mass disease (poisoning of people) and the threat of a mass disease (poisoning of people) they are considered not as acts, but as a socially dangerous consequence. In other words, this kind of criminal-legal construction includes, firstly, the violation of the rules itself and, secondly, socially dangerous consequences in the form of mass illness or poisoning of people or creating a real threat of the onset of these consequences. At the same time, violation of sanitary and epidemiological rules without the occurrence of socially dangerous consequences or the threat of such consequences entails administrative responsibility under Articles 6.3 — 6.7 of the Administrative Code of the Russian Federation.The author notes that an act that creates a real threat to law enforcement facilities provided for in Part 1 of Article 236 of the Criminal Code of the Russian Federation has a lower degree of public danger compared to such actions (inaction) that inadvertently lead to mass illness or poisoning of people. Equalizing the limits of criminal liability for the commission of the two abovementioned torts is a violation of the principle of justice. In this regard, the author of this article proposes in Part 1 of Article 236 of the Criminal Code of the Russian Federation to establish responsibility for violation of sanitary and epidemiological rules if such violation created a threat of mass illness or poisoning of people. In turn, criminal liability for violation of sanitary and epidemiological rules, which inadvertently caused mass illness or poisoning of people, should be established in Part 2 of Article 236 of the Criminal Code of the Russian Federation, which provides for a more severe punishment.
On the issue of changes in labor legislation on remote (remote) work (experience of the COVID-19 pandemic)
Authors: Kashekhlebova E. A.
Published: November 2021

The sphere of social and labor rights has undergone a large-scale transformation due to the COVID-19 pandemic and related restrictive measures. Almost all enterprises and organizations during the period of restrictive measures were forced to switch to a remote (remote) mode of operation. Some, and sometimes all, employees of organizations were forced to perform their labor function, stipulated by an employment contract, at home.At the same time, before the introduction of the above-mentioned forced measures and subsequent amendments to the labor legislation regarding the regulation of the work of “homeworkers”, there were no provisions in the domestic labor legislation that would allow establishing legal regulation of the emergence of this kind of relationship between an employee and an employer.In December 2020, the Federal Law “On Amendments to the Labor Code of the Russian Federation regarding the regulation of remote (remote) work and temporary transfer of an employee to remote (remote) work on the initiative of the employer in exceptional cases” was adopted.This article is devoted to a conceptual review of the amendments to the Labor Code of the Russian Federation adopted in 2020, aimed at establishing the regulation of remote (remote) work, as well as the procedure for temporary transfer of an employee to remote (remote) work on the initiative of the employer in strictly exceptional cases.
On the problems of implementing measures of social support for health workers during the COVID-19 pandemic
Authors: Shalberkina M. N.
Published: November 2021

The article is devoted to the study of problems related to the implementation of social support measures for healthcare workers in the context of the development of the COVID-19 pandemic and its consequences. In order to assess the current system of social support measures for medical workers, the author turns to a retrospective analysis of social support measures contained in the previously existing legislation. From the author’s point of view, today the most effective mechanism is the measures of material incentives taken, carried out in the form of payments.Attention is drawn to the lack of unified approaches to the implementation of incentive measures in practice, in particular, in the constituent entities of the Federation. The author emphasizes the imperfection of the current system of compulsory medical insurance and the importance of introducing a regime of “special regulation of health protection”. A positive assessment of the financial budgeting system is given, with the help of which it was possible to launch the mechanism of “payments to medical workers during the COVID-19 pandemic” in a timely manner.
Dmitry Oskarovich Ott and his contribution to obstetrics and gynecology
Authors: Ailamazyan E. K. , Tsvelev Yury V. , Bezhenar V. F.
Published: November 2021

The history of St. Petersburg keeps many great names that made the glory of Russian science and medicine, including such giants as N.I. Pirogov, S.P. Botkin, I.P. Pavlov, V.M. Bekhterev. The name of Dmitry Oskarovich Ott is certainly in this row.
Surgical correction of congenital malformations of the fetus and newborn
Authors: Kulakov V. I.
Published: November 2021

Over the past decade, the problem of congenital malformations has acquired great medical and social significance. The urgency of the problem and the priority of the development of this direction has increased in connection with the introduction into practice of methods of prenatal diagnostics, which created the basis for the active prevention of the birth of children with multiple developmental anomalies or their timely surgical correction. The significance and state of this problem is evidenced by statistics. According to the National American Center for Birth Defects, 10 to 20 million babies with congenital anomalies are born annually in the world.
Modern views on some topical issues of laparoscopic surgery in gynecology
Authors: Savelieva G. M.hj , Kurtser M. A. , Aziev O. V. , Shtyrov S. V. , Bugerenko A. E.
Published: November 2021

To date, more than 30,000 laparoscopic operations have been performed at the clinical bases of the department (31st City Clinical Hospital and TsPSiR). The widespread introduction into clinical practice of laparoscopic interventions for various pathologies of the genitals and the accumulated experience of their implementation made it necessary to revise some approaches and determine the most optimal, scientifically grounded positions when choosing an operative access and methods for performing gynecological operations.
Diagnostic accuracy of fertiloscopy in the examination of patients with infertility
Authors: Dubnitskaya L. V. , Bakanova D. N. , Nazarenko T. A.
Published: November 2021

The urgency of the problem. Clinical studies indicate that the tuboperitoneal factor is the most common cause of infertility (40 - 70%). It is known that the informative value of the indirect methods for assessing the state of the pelvic organs (ultrasound scanning, GHA, EchoGss), widely used to date, does not exceed 60 - 70%. The direct visualization method - transabdominal laparoscopy (LS) - is highly informative, almost 100%. However, at the diagnostic stage, the use of this method is not always justified, because requires hospital conditions, general anesthesia, is quite aggressive and invasive. In this regard, the endoscopic method - fertiloscopy (a combination of transvaginal hydrolaparoscopy, chromohydrotubation and hysteroscopy), which is distinguished by simplicity and ease of implementation, seems to be promising.The aim of the study was to study the availability and information content of fertiloscopy in the examination of patients with infertility.
Emergency surgery for complicated inflammatory diseases of the uterine appendages
Authors: Balakshina N. G. , Koh L. I.
Published: November 2021

The relevance of research. The problem of diagnostics and treatment of purulent inflammatory diseases of the uterine appendages (UHPD) remains relevant.The purpose of this study: to study the quality of care for patients with HVHPM at the prehospital and hospital stages
Symptom of stress incontinence: pathogenesis, differential diagnosis and treatment problems
Authors: Aylamazian Е. К. , Savitskiy G. A. , Niaury D. А. , Sednev О. V. , Ziyatdinova G. М.
Published: November 2021

The symptom of stress incontinence can be the manifestation of the organic and functional pathology of the bladder and urethra. Consequently, there is necessity of the differential approach to the choice of treatment methods. In present article, the problem of stress incontinence is discussed according to pathophysiological point of view.
The microbiological investigations in the diagnostics of infections affecting human reproduction
Authors: Savicheva A. М. , Bashmakova М. A.
Published: November 2021

In the article there are data concerning the development of research activity in the field of reproductive tract infections fulfilled at the laboratory of microbiology, the D.O.Ott Research Institute of Obstetrics and Gynecology, for last one hundred years. The importance of microbiological investigations in diagnosing genital, perinatal and neonatal infections is underlined. Own data on diagnostics, epidemiology, clinical manifestations of listeriosis, toxoplasmosis, viral and bacterial infections are present in the article.
Hemostasis system and immunomorphologic state of placenta under presence of antiphospholipid antibodies in plasma with consideration of their class and pregnancy outcome
Authors: Kosheleva N. G. , Zubzhitskaia L. В. , Arzhanova О. N. , Tyshkevich О. V. , Gromyko Y. , Shlyakhtenko Т. N. , Pluzhnikova Т. A. , Shapovalova Е. А.
Published: November 2021

The present study was undertaken to investigate hemostasis system of 197 women with recurrent miscarriage: Analysis placentas by immunomorphology are studied of 41 women and of 52 women with autoimmune antibodies to 2-glycoprotein-I (2-GPI) in placenta. There was exposed hyperactivation platelets blood of all women with antiphospholipid antibodies irrespective of groups with significantly was increased at the beginning of pregnancy and progressed with growing gestation. As result of investigation it is determined certain connection between outcome of pregnancy and activation degree platelets blood in vasculars. Was found absence influence anticardiolipin antibodies (aCL) on plasmocoagulative link hemostasis. The circulation of lupus anticoagulant (LA) was accompanied indication of hypercoagulation. In all research groups was determined significant oppression of fibrinolisis. Analysis placentas by immunomorphology was determined significantly tissue damages with LA and 2-GPI-dependent aCL.
Development of the conception about universe hemodynamic reactions in the functional system: mother-placenta-fetus
Authors: Konstantinova N. N. , Pavlova N. G.
Published: November 2021

In this article, one discusses the development of conceptions concerning the functional system motherplacentafetus and the pathogenic fnechanisms of hemodynamic reactions happening in it during pregnancy.