bluuebunny/crossref_metadata_2025 huggingface dataset:
Harnack's Inequality for Stokes Graph
Authors: Kovaleva Maria O. , Popov Igor Yu.
Published: October 2016

A metric graph model is suggested for the Stokes flow concentrated in a neighborhood of a network. Conditions of

\delta

'-type are assumed at the graph vertices. Sign preserving solutions are studied. The analogue of the Harnack's inequality is proved.
Bounds for the Weighted Hardy-Cesàro Operator and its Commutator on Morrey-Herz Type Spaces
Authors: Chuong Nguyen Minh , Duong Dao Van , Hung Ha Duy
Published: October 2016

In this paper we will prove the boundedness of weighted Hardy-Cesàro operator on Herz and Morrey-Herz spaces with absolutely homogeneous weights. The corresponding operator norms are obtained. We also prove the boundedness of the commutators of Hardy-Cesàro operator on weighted spaces of Morrey-Herz type, with their symbols belong to Lipschitz space. By these we extend and strengthen previous results due to Kuang [15], Fu et al. [9] and Tang et al. [20].
DEFINING SIMPLE nD OPERATIONS BASED ON PRISMATIC nD OBJECTS
Authors: Arroyo Ohori K. , Ledoux H. , Stoter J.
Published: October 2016

Abstract. An alternative to the traditional approaches to model separately 2D/3D space, time, scale and other parametrisable characteristics in GIS lies in the higher-dimensional modelling of geographic information, in which a chosen set of non-spatial characteristics, e.g. time and scale, are modelled as extra geometric dimensions perpendicular to the spatial ones, thus creating a higher-dimensional model. While higher-dimensional models are undoubtedly powerful, they are also hard to create and manipulate due to our lack of an intuitive understanding in dimensions higher than three. As a solution to this problem, this paper proposes a methodology that makes nD object generation easier by splitting the creation and manipulation process into three steps: (i) constructing simple nD objects based on nD prismatic polytopes – analogous to prisms in 3D –, (ii) defining simple modification operations at the vertex level, and (iii) simple postprocessing to fix errors introduced in the model. As a use case, we show how two sets of operations can be defined and implemented in a dimension-independent manner using this methodology: the most common transformations (i.e. translation, scaling and rotation) and the collapse of objects. The nD objects generated in this manner can then be used as a basis for an nD GIS.
FACILITATING THE 3D INDOOR SEARCH AND RESCUE PROBLEM: AN OVERVIEW OF THE PROBLEM AND AN ANT COLONY SOLUTION APPROACH
Authors: Tashakkori H. , Rajabifard A. , Kalantari M.
Published: October 2016

Abstract. Search and rescue procedures for indoor environments are quite complicated due to the fact that much of the indoor information is unavailable to rescuers before physical entrance to the incident scene. Thus, decision making regarding the number of crew required and the way they should be dispatched in the building considering the various access points and complexities in the buildings in order to cover the search area in minimum time is dependent on prior knowledge and experience of the emergency commanders. Hence, this paper introduces the Search and Rescue Problem (SRP) which aims at finding best search and rescue routes that minimize the overall search time in the buildings. 3D BIM-oriented indoor GIS is integrated in the indoor route graph to find accurate routes based on the building geometric and semantic information. An Ant Colony Based Algorithm is presented that finds the number of first responders required and their individual routes to search all rooms and points of interest inside the building to minimize the overall time spent by all rescuers inside the disaster area. The evaluation of the proposed model for a case study building shows a significant improve in search and rescue time which will lead to a higher chance of saving lives and less exposure of emergency crew to danger.
INDOOR A* PATHFINDING THROUGH AN OCTREE REPRESENTATION
OF A POINT CLOUD
Authors: Rodenberg O. B. P. M. , Verbree E. , Zlatanova S.
Published: October 2016

Abstract. There is a growing demand of 3D indoor pathfinding applications. Researched in the field of robotics during the last decades of the 20th century, these methods focussed on 2D navigation. Nowadays we would like to have the ability to help people navigate inside buildings or send a drone inside a building when this is too dangerous for people. What these examples have in common is that an object with a certain geometry needs to find an optimal collision free path between a start and goal point. This paper presents a new workflow for pathfinding through an octree representation of a point cloud. We applied the following steps: 1) the point cloud is processed so it fits best in an octree; 2) during the octree generation the interior empty nodes are filtered and further processed; 3) for each interior empty node the distance to the closest occupied node directly under it is computed; 4) a network graph is computed for all empty nodes; 5) the A* pathfinding algorithm is conducted. This workflow takes into account the connectivity for each node to all possible neighbours (face, edge and vertex and all sizes). Besides, a collision avoidance system is pre-processed in two steps: first, the clearance of each empty node is computed, and then the maximal crossing value between two empty neighbouring nodes is computed. The clearance is used to select interior empty nodes of appropriate size and the maximal crossing value is used to filter the network graph. Finally, both these datasets are used in A* pathfinding.
SWEEPING RASTER CROSS SECTIONS ALONG TRAJECTORIES
IN THREE-DIMENSIONAL VOXEL MODELS
Authors: Gorte B. , Zlatanova S. , Leidner A.
Published: October 2016

Abstract. The paper presents a new algorithm to reconstruct elongated objects defined by cross sections and trajectories in gridded threedimensional models represented as voxels. Examples of such objects are the elements of underground infrastructure in urban environments, such as pipes, conduits and tunnels. Starting from a basic methodology, which is based on distance transformations, the algorithm is extended in three ways on the basis of Voronoi datasets being produced alongside.
TRENDING TECHNOLOGIES FOR INDOOR FM: LOOKING FOR “GEO” IN INFORMATION
Authors: Gunduz M. , Isikdag U. , Basaraner M.
Published: October 2016

Abstract. Today technological developments in the Architecture Engineering and Construction (AEC) industry provides opportunities to build huge and complex buildings and facilities. In order to operate these facilities and to meet the requirements of the occupants and also to manage energy, waste and to keep all facility services operational, several Facility Management (FM) solutions were developed. This paper starts by presenting a state of art review of research related to Indoor Facility Management Systems. Later, a textual analysis focused to identify the research trends in this field is presented in the paper. The result of the literature review and textual analysis indicates that current research in Indoor FM Systems is underestimating the role of Geoinformation, Geoinformation models and systems.
DEVELOPMENT OF A 3D WEBGIS SYSTEM FOR RETRIEVING AND VISUALIZING CITYGML DATA BASED ON THEIR GEOMETRIC AND SEMANTIC CHARACTERISTICS BY USING FREE AND OPEN SOURCE TECHNOLOGY
Authors: Pispidikis I. , Dimopoulou E.
Published: October 2016

Abstract. CityGML is considered as an optimal standard for representing 3D city models. However, international experience has shown that visualization of the latter is quite difficult to be implemented on the web, due to the large size of data and the complexity of CityGML. As a result, in the context of this paper, a 3D WebGIS application is developed in order to successfully retrieve and visualize CityGML data in accordance with their respective geometric and semantic characteristics. Furthermore, the available web technologies and the architecture of WebGIS systems are investigated, as provided by international experience, in order to be utilized in the most appropriate way for the purposes of this paper. Specifically, a PostgreSQL/ PostGIS Database is used, in compliance with the 3DCityDB schema. At Server tier, Apache HTTP Server and GeoServer are utilized, while a Server Side programming language PHP is used. At Client tier, which implemented the interface of the application, the following technologies were used: JQuery, AJAX, JavaScript, HTML5, WebGL and Ol3-Cesium. Finally, it is worth mentioning that the application’s primary objectives are a user-friendly interface and a fully open source development.
STATE OF THE ART OF THE LANDSCAPE ARCHITECTURE SPATIAL DATA MODEL FROM A GEOSPATIAL PERSPECTIVE
Authors: Kastuari A. , Suwardhi D. , Hanan H. , Wikantika K.
Published: October 2016

Abstract. Spatial data and information had been used for some time in planning or landscape design. For a long time, architects were using spatial data in the form of topographic map for their designs. This method is not efficient, and it is also not more accurate than using spatial analysis by utilizing GIS. Architects are sometimes also only accentuating the aesthetical aspect for their design, but not taking landscape process into account which could cause the design could be not suitable for its use and its purpose. Nowadays, GIS role in landscape architecture has been formalized by the emergence of Geodesign terminology that starts in Representation Model and ends in Decision Model. The development of GIS could be seen in several fields of science that now have the urgency to use 3 dimensional GIS, such as in: 3D urban planning, flood modeling, or landscape planning. In this fields, 3 dimensional GIS is able to support the steps in modeling, analysis, management, and integration from related data, that describe the human activities and geophysics phenomena in more realistic way. Also, by applying 3D GIS and geodesign in landscape design, geomorphology information can be better presented and assessed. In some research, it is mentioned that the development of 3D GIS is not established yet, either in its 3D data structure, or in its spatial analysis function. This study literature will able to accommodate those problems by providing information on existing development of 3D GIS for landscape architecture, data modeling, the data accuracy, representation of data that is needed by landscape architecture purpose, specifically in the river area.
3D GEOVISUALIZATION & STYLIZATION TO MANAGE COMPREHENSIVE AND
PARTICIPATIVE LOCAL URBAN PLANS
Authors: Brasebin M. , Christophe S. , Jacquinod F. , Vinesse A. , Mahon H.
Published: October 2016

Abstract. 3D geo-visualization is more and more used and appreciated to support public participation, and is generally used to present predesigned planned projects. Nevertheless, other participatory processes may benefit from such technology such as the elaboration of urban planning documents. In this article, we present one of the objectives of the PLU++ project: the design of a 3D geo-visualization system that eases the participation concerning local urban plans. Through a pluridisciplinary approach, it aims at covering the different aspects of such a system: the simulation of built configurations to represent regulation information, the efficient stylization of these objects to make people understand their meanings and the interaction between 3D simulation and stylization. The system aims at being adaptive according to the participation context and to the dynamic of the participation. It will offer the possibility to modify simulation results and the rendering styles of the 3D representations to support participation. The proposed 3D rendering styles will be used in a set of practical experiments in order to test and validate some hypothesis from past researches of the project members about 3D simulation, 3D semiotics and knowledge about uses.
Situação da violência contra crianças e adolescentes no Brasil
Authors: Quadros Marciano Nascimento de , Kirchner Rosane Maria , Hildebrandt Leila Mariza , Leite Marinês Tambara , Costa, Marta Cocco da , Sarzi Diana Mara
Published: October 2016

Objetivo: Verificar las ocurrencias de violencia física y psicológica/moral contra niños y adolescentes, en las regiones geográficas de Brasil en el año 2012.

Método: Estudio documental de abordaje cuantitativo y descriptivo. Los datos fueron colectados en el Sistema de Información de Agravios de Notificación en el cual se utilizó la modalidad “violencia física y psico/moral” en intervalos de edad de <1 año a 14 años en las diferentes regiones de Brasil en el 2012. El análisis de los datos se realizó con ayuda de la estadística descriptiva (tablas simples y cruzadas, figuras y tasas), utilizando el Microsoft Office Excel, versión 2007.

Resultados: De las 8397 ocurrencias de violencia psicológica/moral, 62,7% fueron dirigidos a ambulatorios y en 6,3% ocurrió el ingreso hospitalario, siendo la mayor frecuencia en el sexo femenino. En los 14125 casos registrados de violencia física, 54,2% fueron dirigidos a ambulatorios y 13,6% tuvieron ingreso hospitalario, ocurriendo con mayor incidencia también en el sexo femenino. En cerca de 1/3 de los atendidos ocurrió falta de registros.

Conclusión: Existe la necesidad de políticas específicas y soporte profesional que vengan a prevenir, combatir y asistir la violencia contra niños y adolescentes pudiendo reducir el grado de inseguridad, así como el incremento del número de notificaciones.
Prevalencia de la Lactancia Materna en Huelva, duración y factores relacionados
Authors: Tierra Burguillo María del Pilar , Villa Campos Zahira , Marín Sánchez Carmen , Pedregal González Miguel , Muñoz Soriano Mª Isabel , Álvarez Palacios Mª del Pino
Published: October 2016

Objetivos: Conocer la prevalencia y duración de la Lactancia Materna (LM), así como la relación con las variables sociodemográficas, obstétricas y de educación materno infantil.

Diseño: Estudio observacional descriptivo. Emplazamiento: siete centros de salud de Huelva capital. Participantes: 268 mujeres con niños de 1 a 2 años. La selección se hizo consecutiva, por orden de llegada. Mediciones principales: prevalencia y duración de LM, características sociodemográficas, características perinatales y alimentación complementaria.

Resultados: Iniciaron la LM exclusiva un 52,9 % (IC:46,99-58,91). A los seis meses permanecen un 19,7% (IC:15,33-24,87). Un 63,4% (IC:57,54-69,04) comienzan lactancia materna total (exclusiva o mixta), un 47,7% (IC:41,82-53,75) continúa con ella a los 3 meses y un 26,1% (IC:21,12-31,63) a los 6 meses. La LM está relacionada con: la formación académica de la madre, el número de hijos, asistir a los talleres de preparación al parto, número de sesiones, nivel de satisfacción con respecto a la educación materno infantil, haber solicitado ayuda sobre LM, conocer el grupo de apoyo a la lactancia y haber asistido al mismo.

Conclusiones: La prevalencia de LM es baja con respecto a lo esperado por los datos nacionales, la duración de la misma se aparta de las recomendaciones de la OMS y el nivel educativo de la madre favorece la prevalencia y duración de la LM. Los profesionales de la salud debemos continuar con su promoción y apoyo.
Expressões da violência institucionalizada ao parto: uma revisão integrativa
Authors: Cassiano Alexandra Do Nascimento , Santos Milena Gabriela dos , Santos Flávia Andréia Pereira Soares dos , Holanda Cristyanne Samara Miranda de , Maranhão Tércia Maria de Oliveira , Enders Bertha Cruz , Leite de Carvalho Jovanka Bitencourt
Published: October 2016

Este estudio tuvo como objetivo sintetizar la literatura científica publicada en artículos sobre las formas de violencia institucionalizada que se producen durante el parto. Se trata de una revisión integradora realizada en bases SCIELO, SCOPUS, PubMed y LILACS, utilizando los descriptores Childbirth AND “Parturition” AND “Obstetric” AND “Violence”. 13 artículos fueron seleccionados tras atender los criterios de inclusión y exclusión. Del análisis de los estudios emergieron cinco categorías, a saber: violencia institucional en las relaciones de poder; violencia institucional al cuerpo femenino; violencia institucional a través de la comunicación; violencia institucional en la modalidad de servicio; y violencia institucional como una violación de los derechos. A pesar de que la literatura científica sobre el tema va en aumento, la cantidad de estudios es todavía incipiente y bajo el nivel de evidencia científica.
Análisis bibliométrico de los artículos sobre cuidado de enfermería publicados en revistas colombianas
Authors: Camacho Rodríguez Doriam Esperanza , Oviedo Córdoba Haidy Rocio , Ramos de la Hoz Ediltrudis , Gonzalez Noguera Tatiana Cecilia
Published: October 2016

Objetivo: Realizar un análisis bibliométrico de los artículos sobre cuidado de enfermería, publicados en revistas Colombianas.

Materiales y método: Estudio bibliométrico descripti¬vo, retrospectivo. Se analizaron 95 artículos publicados en 18 revistas colombianas indexadas en Publindex, durante los años 2010 a 2015. La búsqueda se realizó mediante los descriptores: cuidado, modelos de enfermería, teoría de enfermería. El análisis descriptivo se realizó mediante una hoja de Excel y se analizaron los indicadores bibliométricos de productividad, citación, contenido y metodológicos.

Resultados: Se observa un incremento en la publicación en los últimos 5 años, siendo los artículos de investigaciones originales los que más se publican y las Instituciones que más publican son las Universidades de Bogotá y Antioquia. En relación con los indicadores de citación, el Índice de Price fue de 37,45%, en tanto que el índice de aislamiento fue de 33,67%  y el índice de auto citación fue de 1,85%. Sobre los indicadores de colaboración, el índice de coautoría fue de 2,7 y  el índice de colaboración institucional fue de 1,3.

Conclusiones: Se observa un incremento en la producción científica de Enfermería en Colombia, no obstante, se hace necesario ampliar los indicadores de colaboración.
S.VA.M.Di.: a new opportunity for the National Health System
Authors: De Simoni Simona , Arriga Cecilia , Dari Silvia , Cimarello Giuseppe
Published: October 2016

Multi-dimensional assessment is still evolving today. Object of our study is not only the transition from the S.Va.M.A form («Scheda per la valutazione multidimensionale dell’anziano» – Questionnaire for multidimensional evaluation of the elderly) to the S.Va.M.Di form («Scheda di valutazione multidimensionale del disabile» – Questionnaire for the multidimensional assessment of disabled individuals), but the administration of S.VA.M.Di to subjects included in a «PAI» («Piano assistenziale individuale» – Individual Assistance Plan). This integration is designed to facilitate the access of patients to home care, integrated home care and residential and semi-residential care.During 2015 the S.VA.M.Di questionnaire was administered on an experimental basis within the Adult Disability Service of ASL Viterbo to a random mode selected sample of 108 residents of the Viterbo province with a diagnosis of mental retardation (mild, moderate, moderate/severe and severe).S.VA.M.Di is an anamnestic, diagnostic, evaluative and prescriptive tool, useful for an integrated approach in the patient’s care in the health, social health and / or social dimensions; it is a tool that describes the decision processes and allows statistical and epidemiological analysis.The analysis of the results showed that the S.VA.M.Di is certainly a very complex questionnaire to be completed, in terms of working hours devoted to the writing and the complexity in processing. However, it has considerable advantages as regards the completeness and accuracy of the data collected. Essential for its implementation and adoption is the adequate training of health professionals involved.
A multi-protein receptor-ligand complex underlies combinatorial dendrite guidance choices in C. elegans
Authors: Zou Wei , Shen Ao , Dong Xintong , Tugizova Madina , Xiang Yang K , Shen Kang
Published: October 2016

Ligand receptor interactions instruct axon guidance during development. How dendrites are guided to specific targets is less understood. The C. elegans PVD sensory neuron innervates muscle-skin interface with its elaborate dendritic branches. Here, we found that LECT-2, the ortholog of leukocyte cell-derived chemotaxin-2 (LECT2), is secreted from the muscles and required for muscle innervation by PVD. Mosaic analyses showed that LECT-2 acted locally to guide the growth of terminal branches. Ectopic expression of LECT-2 from seam cells is sufficient to redirect the PVD dendrites onto seam cells. LECT-2 functions in a multi-protein receptor-ligand complex that also contains two transmembrane ligands on the skin, SAX-7/L1CAM and MNR-1, and the neuronal transmembrane receptor DMA-1. LECT-2 greatly enhances the binding between SAX-7, MNR-1 and DMA-1. The activation of DMA-1 strictly requires all three ligands, which establishes a combinatorial code to precisely target and pattern dendritic arbors.
C. elegans GLP-1/Notch activates transcription in a probability gradient across the germline stem cell pool
Authors: Lee ChangHwan , Sorensen Erika B , Lynch Tina R , Kimble Judith
Published: October 2016

C. elegans Notch signaling maintains a pool of germline stem cells within their single-celled mesenchymal niche. Here we investigate the Notch transcriptional response in germline stem cells using single-molecule fluorescence in situ hybridization coupled with automated, high-throughput quantitation. This approach allows us to distinguish Notch-dependent nascent transcripts in the nucleus from mature mRNAs in the cytoplasm. We find that Notch-dependent active transcription sites occur in a probabilistic fashion and, unexpectedly, do so in a steep gradient across the stem cell pool. Yet these graded nuclear sites create a nearly uniform field of mRNAs that extends beyond the region of transcriptional activation. Therefore, active transcription sites provide a precise view of where the Notch-dependent transcriptional complex is productively engaged. Our findings offer a new window into the Notch transcriptional response and demonstrate the importance of assaying nascent transcripts at active transcription sites as a readout for canonical signaling.
Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice
Authors: Cavanagh Sean E , Wallis Joni D , Kennerley Steven W , Hunt Laurence T
Published: October 2016

Correlates of value are routinely observed in the prefrontal cortex (PFC) during reward-guided decision making. In previous work (Hunt et al., 2015), we argued that PFC correlates of chosen value are a consequence of varying rates of a dynamical evidence accumulation process. Yet within PFC, there is substantial variability in chosen value correlates across individual neurons. Here we show that this variability is explained by neurons having different temporal receptive fields of integration, indexed by examining neuronal spike rate autocorrelation structure whilst at rest. We find that neurons with protracted resting temporal receptive fields exhibit stronger chosen value correlates during choice. Within orbitofrontal cortex, these neurons also sustain coding of chosen value from choice through the delivery of reward, providing a potential neural mechanism for maintaining predictions and updating stored values during learning. These findings reveal that within PFC, variability in temporal specialisation across neurons predicts involvement in specific decision-making computations.
Eficácia do imazapic no controle de capim-camalote aplicado em solos de diferentes texturas
Authors: Guimarães Ana Carolina Dias , Takeshita Vanessa , Catissi Fabrício , Nicolai Marcelo , Christoffoleti Pedro Jacob
Published: October 2016

O capim-camalote (Rottboelia exaltata L.f.) é uma planta daninha com rápida capacidade de disseminação nas áreas canavieiras do Brasil, causando significativas perdas de produtividade na cultura. Assim, esta pesquisa teve como objetivo avaliar a suscetibilidade do capim-camalote ao herbicida imazapic, quando aplicado em pré-emergência, por meio de curvas de dose-resposta. O experimento foi desenvolvido no delineamento experimental do tipo blocos ao acaso com quatro repetições em esquema fatorial entre dois tipos de solo (franco argilo-arenoso e franco arenoso) e nove doses do herbicida imazapic. As doses utilizadas foram: 0; 9,19; 18,38; 36,75; 50; 73; 147; 294; 588 e 1176 g i.a. ha-1 e testemunha sem aplicação. O uso do imazapic causou maior controle e menor matéria seca do capim-camalote quando aplicado em solo franco arenoso, em relação ao solo franco argilo-arenoso. A textura do solo tem influência direta na eficiência de controle, de modo que a dose de 18,38 g i.a. ha-1 demonstrou maior controle do capim-camalote em solo franco arenoso, já para solo franco argilo-arenoso foi de 294 g i.a. ha-1. Os níveis de controle indicam a viabilidade de aplicação de imazapic em pré-emergência para controle do capim-camalote.
Waiting at Nemi: Wellhausen, Gunkel, and the World Behind Their Work
Authors: Kurtz Paul Michael
Published: October 2016

In the first edition of his now fabled Golden Bough, James George Frazer began with the tale of an unnamed priest-king waiting for his slayer and successor in the sacred grove at Nemi. “A candidate for the priesthood could only succeed to office by slaying the priest,” wrote the armchair anthropologist, “and having slain him he held office till he was himself slain by a stronger or a craftier.” Scholars of the Hebrew Bible have often cast their own history in these terms: if the established August Dillmann or Franz Delitzsch fell to a trailblazing Julius Wellhausen, Wellhausen himself succumbed to a pathfinding Hermann Gunkel. For the period after “the triumph of Wellhausen”—to use language from John Rogerson's classic history—the scope then usually narrows, with Wellhausen and Gunkel forming legendary foils. Which of them, exactly, has rightful claim to the crown or represents the true hierarch of the Hebrew Bible muse depends upon the narrator's own disposition. Indeed, experts in biblical studies have long juxtaposed the two as intellectual opposites. In the process, they appear, ofttimes, as almost mythic figures, largely bereft of context—historical milieu otherwise being a crucial component of biblical scholarship for well over a century.
Nivaĉle (shichaam lhavos variety)
Authors: Gutiérrez Analía
Published: October 2016

Nivaĉle [niβaˈe] (ISO 639-3: cag) is a Mataguayan language spoken in the Argentinean and Paraguayan Chaco by approximately 16,350 speakers in Paraguay (DGEEC 2012) and 553 in Argentina (INDEC 2004–2005).
Shared Genetic Factors in the Co-Occurrence of Depression and Fatigue
Authors: Corfield Elizabeth C. , Martin Nicholas G. , Nyholt Dale R.
Published: October 2016

Depression and fatigue have previously been suggested to share an underlying genetic contribution. The present study aims to investigate and characterize the familiality and genetic relationship between depression and fatigue. The familiality of depression and fatigue was assessed by calculating relative risks, measured by the prevalence ratio, within 643 monozygotic (MZ) and 577 dizygotic (DZ) twin pairs. Bivariate twin modeling was utilized to assess the magnitude of shared heritability between depression and fatigue. Finally, the relationship between depression and fatigue was investigated using the co-twin control method, to determine whether the association is explained by causal or non-causal models. We observed an increased risk of fatigue in co-twins of probands with depression and increased risk of depression in co-twins of probands with fatigue. Higher risks were observed in MZ compared to DZ twin pairs, and bivariate heritability analyses indicated significant genetic components for depression and fatigue, with heritability estimates of 48% and 41%, respectively. Importantly, a significant additive genetic correlation of 0.71 [95% CI = 0.51–0.92) and bivariate heritability of 21% [95% CI = 10–35%] was observed between depression and fatigue. Furthermore, results from the co-twin control method indicate a non-causal genetic relationship that likely explains the association between depression and fatigue. Notably, the contribution of shared genetic factors remained significant, independent of the overlapping symptoms, indicating that the relationship between co-occurring depression and fatigue is primarily due to shared genetic factors rather than overlapping symptomatology.
Evaluation of intoxicating effects of liquor products on drunken mice
Authors: Wu Zhiqiang , Tian Xiaofei , He Songgui , Quan Lei , Wei Yunlu , Wu Zhenqiang
Published: October 2016

Consumption of alcoholic beverages increases the risk of human health problems such as liver, heart and blood vessel diseases. This study provided insights and new data for the evaluation of the risks of alcohol consumption on proper behaviour and organ function and increased the awareness of the health risks associated with moderate and heavy drinking.
Photocatalytic degradation of phenol using a new developed TiO2/graphene/heteropoly acid nanocomposite: synthesis, characterization and process optimization
Authors: Rafiee Ezzat , Noori Elham , Zinatizadeh Ali Akbar , Zanganeh Hadis
Published: October 2016

A heteropoly acid-modified TiO2/graphene nanocomposite can be introduced as a promising efficient visible driven photocatalyst to reclaim polluted water.
Oxidized starch as a superior binder for silicon anodes in lithium-ion batteries
Authors: Bie Yitian , Yang Jun , Nuli Yanna , Wang Jiulin
Published: October 2016

Commercial oxidized starch (OS) containing oxidized amylose and oxidized amylopectin is proposed as a superior binder for silicon anodes.
Bundesrat-Vorstoss: Keine Extraspritze für Unikliniken
Authors: Ankowitsch Eugenie
Published: October 2016

Nur ein halbes Jahr nach Inkrafttreten der Klinikreform (KHSG) hat der Bundesrat finanzielle Verbesserungen für Unikliniken und Maximalversorger gefordert. Doch das Gesundheitsministerium lehnt einen Strukturzuschlag erneut ab. Krankenhausverbände wie CKiD, IVKK und BDPK werfen dem Bundesrat indes Einseitigkeit vor.
Two-Stage Indicators to Assess Learning Curves for Minimally Invasive Ivor Lewis Esophagectomy
Authors: Wang Qi , Wu Zixiang , Chen Gang , Zhang Sai , Shen Gang , Wu Ming
Published: October 2016

Background Minimally invasive esophagectomy (MIE) Ivor Lewis has been increasingly performed over the last two decades. To guide the implementation of this technically demanding procedure, a comprehensive assessment of MIE-Ivor Lewis learning curves should include both the general competence to accomplish the procedure and the ability to generate oncological benefits. These objectives are believed to be associated with different phases of the learning curve.

Methods A retrospective review of the first 109 patients who underwent MIE-Ivor Lewis by a single qualified surgeon was conducted. Relevant variables were collected and assessed by regression analysis to identify suitable indicators for patient stratification and learning curve assessment. Thereafter, the differential analysis was performed among groups to validate the learning curve model.

Results Two variables, intrathoracic gastroesophageal anastomosis time and bilateral recurrent laryngeal nerve (RLN) lymphadenectomy number, which plateaued, respectively, after the 26th and 88th cases, were selected as meaningful indicators to identify different competence levels. Therefore, 109 patients were chronologically subcategorized into three groups (the first 26 MIEs as the early group, the next 62 cases as the middle group, and 21 most recent cases as the late group). Perioperative data were compared between groups with positive results to indicate a three-phase model for a learning curve for MIE-Ivor Lewis.

Conclusions An MIE-Ivor Lewis learning curve should include three discrete phases that indicate, successively, unskilled operation (general competence to accomplish, less proficiency), surgical proficiency, and oncological efficacy. Intrathoracic anastomosis time and bilateral RLN lymphadenectomy were identified as suitable indicators delineate the different stages of an MIE-Ivor Lewis learning curve.
How seabirds plunge-dive without injuries
Authors: Chang Brian , Croson Matthew , Straker Lorian , Gart Sean , Dove Carla , Gerwin John , Jung Sunghwan
Published: October 2016

Significance

Plunge-diving is a very unique foraging method in the animal kingdom. A limited set of water birds exhibit this behavior, and only one family of seabirds (Sulidae) exhibit this behavior at high speeds. We studied the stability of the bird’s slender and seemingly fragile neck during a plunge-dive by conducting simple experiments that mimic this behavior. An elegant analysis of the interaction among hydrodynamic forces, neck elasticity, and muscle contraction reveals that seabirds dive at appropriate speeds to avoid injury. Considering the popular recreational sport of diving, we also find a diving speed limit for humans to avoid injury.
Impact of BMI on Ability to Successfully Create an IPAA
Authors: Khasawneh Mohammad A. , McKenna Nicholas P. , Abdelsattar Zaid M. , Johnson Angela , Dozois Eric J. , Pemberton John H. , Mathis Kellie L.
Published: October 2016

BACKGROUND:

IPAA is the surgical treatment of choice for patients with ulcerative colitis. Limited data exist on how obesity impacts the ability of the surgeon to successfully create an IPAA.

OBJECTIVE:

We aimed to determine how BMI affects the ability to successfully complete the operation.

DESIGN:

This was a retrospective cohort study.

SETTINGS:

The study was conducted at a single tertiary care center.

PATIENTS:

We included all of the patients undergoing an IPAA for ulcerative colitis between January 2002 and August 2013 at our institution. A total of 1175 patients underwent proctocolectomy for ulcerative colitis during the study period; 129 were not offered IPAA (reasons included patient preference (n = 53), advanced age/comorbidity (n = 28), obesity (n = 23), incontinence (n = 8), suspicion of Crohn’s disease (n = 8), rectal cancer (n = 3), and other (n = 6)). Twenty-six patients had a concurrent cancer diagnosis, and 5 had a polyposis syndrome.

MAIN OUTCOME MEASURES:

We used logistic regression modeling to estimate the association between BMI and unsuccessful pouch attempts.

RESULTS:

Of the 1046 patients offered IPAA, 19 (1.82%) could not be technically completed at the time of surgery. Increasing BMI was associated with a higher risk of not being able to technically perform IPAA (OR = 1.26 (95% CI, 1.17–1.34)). The chance of an unsuccessful pouch rose from 2.0% at a BMI of 30 to 5.7% at a BMI of 35 and 15.0% at a BMI of 40 (p < 0.01). The area under the receiver operator characteristics curve was 0.82. BMI explained 21% of the variation in pouch success rate.

LIMITATIONS:

This study is limited in its generalizability. Also, the verbosity within the operative dictations varied among surgeons, making it impossible to be certain which maneuvers were performed to gain length in each patient. In addition, we were limited to BMI as a surrogate for visceral obesity, and we did not include medical therapy at the time of IPAA attempt.

CONCLUSIONS:

There is a strong association between increasing BMI and the ability to technically perform IPAA. Obese patients should be counseled to lose weight preoperatively to increase the probability of successful IPAA construction at the time of operation.
Contemporary thromboprophylaxis of trauma patients
Authors: Van Philbert Y. , Schreiber Martin A.
Published: October 2016

Purpose of review

The traumatically injured patient is at high risk for developing venous thromboembolism. Clinical practice guidelines developed by the American College of Chest Physicians and the Eastern Association for the Surgery of Trauma recognize the importance of initiating thromboprophylaxis, but the guidelines lack specific recommendations regarding the timing and dose of pharmacologic thromboprophylaxis. We review the literature regarding initiation of thromboprophylaxis in different injuries, the use of inferior vena cava filters, laboratory monitoring, dosing regimens, and the use of antiplatelet therapy.

Recent findings

Use of pharmacologic thromboprophylaxis with invasive intracranial monitors is not associated with increased bleeding complications. The initiation of low-molecular-weight heparin (LMWH) prophylaxis 48 h postinjury in blunt solid organ injury is not associated with an increase in the rate of failed nonoperative management. Antiplatelet therapy in conjunction with LMWH may help to prevent venous thromboembolism.

In the setting of blunt traumatic brain and solid organ injury, initiation of pharmacologic thromboprophylaxis 48 h after injury is not associated with increased bleeding complications. There is no consensus or clear data showing which dosing regimen of LMWH is most effective or whether routine laboratory measurements are beneficial for determining effective thromboprophylaxis.
Wound induced Ca2+ wave propagates through a simple Release and Diffusion mechanism
Authors: Handly Naomi , Wollman Roy
Published: October 2016

Damage associated molecular patterns (DAMPs) are critical mediators of information concerning tissue damage from damaged cells to neighboring healthy cells. Adenosine triphosphate (ATP) acts as an effective DAMP when released into extracellular space from damaged cells. Extracellular ATP receptors monitor tissue damage and activate a Ca2+ wave in the surrounding healthy cells. How the Ca2+ wave propagates through cells following a wound is unclear. Ca2+ wave activation can occur extracellularly via external receptors or intracellularly through GAP junctions. Three potential mechanisms to propagate the Ca2+ wave are: Source and Sink, Amplifying Wave, and Release and Diffusion. Both Source and Sink and Amplifying Wave regulate ATP levels using hydrolysis or secretion, respectively, while Release and Diffusion relies on dilution. Here we systematically test these hypotheses using a microfluidics assay to mechanically wound an epithelial monolayer in combination with direct manipulation of ATP hydrolysis and release. We show that a Release and Diffusion model sufficiently explains Ca2+ wave propagation following an epithelial wound. A Release and Diffusion model combines the benefits of fast activation at length-scales of ~1-5 cell diameters with a self-limiting response to prevent unnecessary inflammatory responses harmful to the organism.
How Transcranial Magnetic Stimulation over Early Visual Cortex impacts short-term memory precision and guess rate
Authors: Rademaker Rosanne L. , van de Ven Vincent G. , Tong Frank , Sack Alexander T.
Published: October 2016

Neuroimaging studies have demonstrated that activity patterns in early visual areas predict stimulus properties actively maintained in visual short-term memory. Yet, the mechanisms by which such information is represented remain largely unknown. In this study, observers remembered the orientations of 4 briefly presented gratings, one in each quadrant of the visual field. A 10Hz Transcranial Magnetic Stimulation (TMS) triplet was applied directly at stimulus offset, or midway through a 2-second delay, targeting early visual cortex corresponding retinotopically to a sample item in the lower hemifield. Memory for one of the four gratings was probed at random, and participants reported this orientation via method of adjustment. Replication errors were smaller when the visual field location targeted by TMS overlapped with that of the cued memory item, compared to errors for stimuli probed diagonally to TMS. This implied topographic storage of orientation information, and a memory-enhancing effect at the targeted location. Furthermore, early pulses impaired performance at all four locations, compared to late pulses. Next, response errors were fit empirically using a mixture model analysis to characterize memory precision and guess rates. Memory was more precise for items proximal to the pulse location, irrespective of pulse timing. Guesses were more probable with early TMS pulses, regardless of stimulus location. Thus, whereas TMS administered at the offset of the stimulus array might disrupt early-phase consolidation in a topographically unspecific manner, TMS also boosts the precise representation of an item at its targeted retinotopic location, perhaps by increasing attentional resources or by injecting a beneficial amount of noise.
Inuit Knowledge of beluga whale (Delphinapterusleucas) foraging ecology in Nunavik (Arctic Quebec), Canada
Authors: Breton-Honeyman K. , Hammill M.O. , Furgal C.M. , Hickie B.
Published: October 2016

The beluga whale (Delphinapterus leucas (Pallas, 1776)) is expected to be influenced by changes in the environment. In Nunavik, the Arctic region of Quebec, Nunavimmiut (Inuit of Nunavik) have depended on beluga for centuries, developing an extensive understanding of the species and its ecology. Forty semidirective interviews were conducted with Inuit hunters and Elders from four Nunavik communities, who had a range of 28–47 years of beluga hunting experience. Interviews followed an ethnocartographic format and were analyzed using a mixed methods approach. Hunters most commonly reported prey species from the sculpin (Cottidae), cod (Gadidae), salmon (Salmonidae), and crustacean families; regional variations in prey and in foraging habitat were found. Hunters identified significant changes in body condition (i.e., blubber thickness), which were associated with observations about the seasonality of feeding. The timing of fat accumulation in the late fall and winter coupled with the understanding that Hudson Bay is not known as a productive area suggest alternate hypotheses to feeding for the seasonal movements exhibited by these whales. Inuit Knowledge of beluga foraging ecology presented here provides information on diet composition and seasonality of energy intake of the beluga and can be an important component of monitoring diet composition for this species into the future. An Inuttitut version of the abstract is available ( Appendix A ).
A DFT study of structural and electronic properties of Zn1−xSbxTe with x = (0.25,0.50,0.75)
Authors: Diwaker  , Kumar Ashwani
Published: October 2016

In the present work, we report the structural and the electronic properties of the alloy [Formula: see text] with [Formula: see text] and [Formula: see text]. Ab initio calculations are based upon the density functional theory with generalized gradient approximation and Perdew–Burke–Ernzerhof (PBE) exchange–correlation functional. In our calculations, we found that antimony (Sb) doping in zinc telluride (ZnTe) system introduces some bands which mainly originate from [Formula: see text]- and [Formula: see text]-states of Te and Sb atom and are primarily responsible for [Formula: see text]-type and [Formula: see text]-type conductivity.
JRSP of three-particle state via three tripartite GHZ class in quantum noisy channels
Authors: Falaye Babatunde James , Sun Guo-Hua , Camacho-Nieto Oscar , Dong Shi-Hai
Published: October 2016

We present a scheme for joint remote state preparation (JRSP) of three-particle state via three tripartite Greenberger–Horne–Zeilinger (GHZ) entangled states as the quantum channel linking the parties. We use eight-qubit mutually orthogonal basis vector as measurement point of departure. The likelihood of success for this scheme has been found to be [Formula: see text]. However, by putting some special cases into consideration, the chances can be ameliorated to [Formula: see text] and 1. The effects of amplitude-damping noise, phase-damping noise and depolarizing noise on this scheme have been scrutinized and the analytical derivations of fidelities for the quantum noisy channels have been presented. We found that for [Formula: see text], the states conveyed through depolarizing channel lose more information than phase-damping channel while the information loss through amplitude damping channel is most minimal.
Fibroblast Subtypes Regulate Responsiveness of Luminal Breast Cancer to Estrogen
Authors: Brechbuhl Heather M. , Finlay-Schultz Jessica , Yamamoto Tomomi M. , Gillen Austin E. , Cittelly Diana M. , Tan Aik-Choon , Sams Sharon B. , Pillai Manoj M. , Elias Anthony D. , Robinson William A. , Sartorius Carol A. , Kabos Peter
Published: October 2016

Purpose: Antiendocrine therapy remains the most effective treatment for estrogen receptor–positive (ER+) breast cancer, but development of resistance is a major clinical complication. Effective targeting of mechanisms that control the loss of ER dependency in breast cancer remains elusive. We analyzed breast cancer–associated fibroblasts (CAF), the largest component of the tumor microenvironment, as a factor contributing to ER expression levels and antiendocrine resistance.

Experimental Design: Tissues from patients with ER+ breast cancer were analyzed for the presence of CD146-positive (CD146pos) and CD146-negative (CD146neg) fibroblasts. ER-dependent proliferation and tamoxifen sensitivity were evaluated in ER+ tumor cells cocultured with CD146pos or CD146neg fibroblasts. RNA sequencing was used to develop a high-confidence gene signature that predicts for disease recurrence in tamoxifen-treated patients with ER+ breast cancer.

Results: We demonstrate that ER+ breast cancers contain two CAF subtypes defined by CD146 expression. CD146neg CAFs suppress ER expression in ER+ breast cancer cells, decrease tumor cell sensitivity to estrogen, and increase tumor cell resistance to tamoxifen therapy. Conversely, the presence of CD146pos CAFs maintains ER expression in ER+ breast cancer cells and sustains estrogen-dependent proliferation and sensitivity to tamoxifen. Conditioned media from CD146pos CAFs with tamoxifen-resistant breast cancer cells are sufficient to restore tamoxifen sensitivity. Gene expression profiles of patient breast tumors with predominantly CD146neg CAFs correlate with inferior clinical response to tamoxifen and worse patient outcomes.

Conclusions: Our data suggest that CAF composition contributes to treatment response and patient outcomes in ER+ breast cancer and should be considered a target for drug development. Clin Cancer Res; 23(7); 1710–21. ©2016 AACR.
Dos Classics Illustrated à Edição Maravilhosa: Victor Hugo entre textos e paratextos (1949-1959)
Authors: Silva-Reis Dennys , Lucatelli Bárbara Guimarães
Published: October 2016

O presente artigo analisa quatro HQs inspiradas nos romances de Victor Hugo e suas respectivas traduções para o português: O Corcunda de Notre Dame (1949) – The Hunchback of Notre Dame (1946), Os miseráveis (1951) – Les Miserables (1943), Os Trabalhadores do Mar (1952) – The Toilers of the Sea (1949), e O Homem que Ri (1952) – The Man Who Laughs (1950). Para tal empreendimento nos detemos na observação do texto traduzido e na comparação entre paratextos que acompanham a tradução e o texto fonte. Desta forma, mostramos que enquanto as HQs em inglês eram produzidas como motivação para leitura dos clássicos, os brasileiros tentavam alcançar o status de Literatura.