bluuebunny/crossref_metadata_2025 huggingface dataset:
Protection against rotenone-induced animal model of Parkinson’s disease: Electrophysiological, behavioral and histological study
Authors: Darbinyan Lilit , Hambardzumyan Lilia , Manukyan Larisa , Sarkisian Vaghinak
Published: February 2022

Parkinson's disease (PD) is an age-related neurodegenerative disease characterized clinically as a movement disorder. A hallmark feature of PD is the degeneration of the dopamine neurons in the substantia nigra pars compacta  and the consequent striatal dopamine  deficiency. The lack of dopamine causes the primary symptoms of PD- tremor, slowness of movement, muscle stiffness and balance problems.  Research is devoted to the study of systemic compensatory reactions of the rat's brain developing in response to rotenone-induced animal model of PD under the conditions of neuroprotective intervention of Curcumin. This has raising expectations for the development of new neuroprotective therapies for the prevention of PD. Male albino rats were treated with rotenone injections (2.5 mg/ml intraperitoneally) for 21 days.We examined the effects of neuroprotector curcumin (200 mg/kg) on behavior and the electrical activity of hippocampus neurons measured in response to high frequency stimulation (HFS) of entorhinal cortex (EC). In the hippocampus, the excitatory and inhibitory synapses between EC and CA3 pyramidal cells expresses robust forms of short-term plasticity, such as frequency facilitation  (post-tetanic potentiation – PTP) and depression (post-tetanic depression – PTD). Motor activity was assessed by cylinder test. The results showed that Rotenone causes significant reduction of neuronal activity, whereas curcumin can improve the motor impairments and electrophysiological parameters and may be beneficial in the treatment of PD. Curcumin significantly prevented rotenone-induced impairment of hippocampal synaptic plasticity, which is likely mediated via dysfunction of mitochondrial complex I. It alleviated the deficits behavior in rats as the rearing frequencies of animals were enhanced.

Keywords:  Parkinson's disease, rotenone-induced animal model, electrophysiological parameters, deficits behavior.
Fear of childbirth and high stress are predictive of psychological disturbances during pregnancy
Authors: Guerroumi Maroua , Aquil Amina , El Kherchi Ouassil , Elgot Abdeljalil
Published: February 2022

Mental health disorders, particularly psychological distress in women in the last trimester of pregnancy, are generally underestimated and under-diagnosed by health professionals. Thus, this quantitative descriptive study has the following main objectives: a) to evaluate depressive and anxiety disorders during the third trimester of pregnancy, b) to identify certain risk factors of these mental problems and, c) to determine the impact of these disorders on the quality of life of pregnant women.

To achieve these objectives, a validated questionnaire translated into dialectal Arabic was used with 178 pregnant women in the third trimester of their pregnancy, the majority of whom were in the last month of gestation. Our study was conducted in the Marrakech-Safi region in two urban health centres: the Oasis, Youssef Ben Tachfine and a delivery unit.

The results we obtained in this work showed that anxiety is proven in 60.11% of pregnant women and only 44.38% are diagnosed as depressed, while a percentage of about 79.21% of parturients showed that they suffer from the anxiety-depression syndrome. High stress levels, body dissatisfaction caused by pregnancy and even fear of childbirth are preliminary risk factors for anxiety and depression in the last trimester of pregnancy, not to mention the the relieving effect of self-esteem against these mental disorders.

As a result of this work, and in order to combat these health problems throughout pregnancy, it has been necessary to integrate preventive and sometimes curative measures in the prenatal medical follow-up.

Keywords: Mental Health, Anxiety, depression, Quality of life
Protective effect of bacterial melanin in the substantia nigra in a rat model of Parkinson's disease
Authors: Danielyan M. H. , Nebogova K.A. , Khachatryan V.P. , Poghosyan M.V. , Karapetyan K.V.
Published: February 2022

The major cause of Parkinson's disease is progressive disturbance of dopaminergic neurons of the substantia nigra, as well as their nerve endings located in the striatum. Therefore, therapy aimed at slowing the death of dopaminergic neurons can be effective. In recent decades, various types of neuroprotective agents have been successfully used in the treatment of neurodegenerative diseases, after which the restoration of structural disfunctions of the CNS is accelerated. In the present study, we used bacterial melanin, the therapeutic effect of which is due to the improvement of the trophic effects of the brain tissue, inhibition of the inflammatory process and gliosis. The comparative study of morphological and functional state of the substantia nigra pars compacta in a rotenone model of Parkinson's disease and combined with introduction of bacterial melanin was carried out. For morphological and histochemical study, the method of detecting the activity of Ca2 + - dependent acid phosphatase was used. The analysis of the data obtained showed that during rotenone intoxication, neuronal death and substantia nigra depigmentation are observed, as well as sharp morphological changes in intracellular structures occur, which indicates gross metabolic and morphological disorders. With the introduction of bacterial melanin, there is a tendency to preserve the normal morphological picture of the neurons of the substantia nigra pars compacta, in comparison with the Parkinson's disease model.  Thus, bacterial melanin acts as a neuroprotective agent and has a supportive role in Parkinson's disease. 

Keywords:  bacterial melanin, Parkinson's Disease, substantia nigra
A new synesthesia-based approach for AI in healthcare
Authors: EL HANDRI Kaoutar , EL AHRACH Sanae , TOUIL Mohamed
Published: February 2022

Recent changes in all fields have rapidly taken place, causing radical changes in various spheres of our society. They have particularly affected artificial intelligence, whose priority is to adopt several human qualities to adapt to the changes.

AI algorithms inspired by human characteristics and behavioral patterns vary with the paradigms of big data for satisfying individual requirements and treating the problems of the development of creative reasoning. Therefore, getting inspired by highly complex neurological phenomena and behaviors, whether typical or atypical such as synesthesia, is recommended in learning.  The evolution of science confirms the theory and methodology of synesthesia. Therefore, it has been focused on the individual's problem identifying different neuroscientific characteristics and explaining their specific potential in developing creativity.  Inspired by this, our work focuses on understanding the phenomenon of sound synesthesia in creative thinking, which is a kind of additional mechanism for the perception and development of skills and abilities to analyze the relationship between sound and color in the text.

The approach based on the system-activity correlation was applied in work, ensuring the research's integrity, complexity, structure, and purpose.  Finally, we aim to find the symbolism of sounds that supports the semantic core of the meaning of linguistic signs.

The NLP (Natural Language Processing) is producing new based models while developing the creative thinking of machines to evolve that of people, aiming to help them reach the rapid changes of the modern world.

Key words:  synesthesia, artificial intelligence, algorithms, neurodiverse, learning, correlation.
Radiation dose and image quality in abdominal CT: Phantom Study
Authors: EL MANSOURI M'hamed , CHOUKRI Abdelmajid , TALBI Mohammed , KHALLOUKI Othmane
Published: February 2022

The purpose of this study was to evaluate and compare the effect of acquisition parameters of the abdominal computed tomography protocol on image quality and dose quantities, including contrast-to-noise ratio (CNR), noise, spatial resolution (SR) as well as volumetric computed tomography dose index (CTDIv).

The measurements have been done on a HITACHI 16-slice scanner using two phantoms (PMMA and Catphan 500), two tube voltages of 120KVp and 100KVp have been analyzed while varying the tube current settings from 155 to 300 (mAs) in order to measure the abdominal image quality quantities and dose (CTDIv).

The scanning at 100KVp compared to 120KVp has resulted in a dose reduction up to 38% at mAs ranging from 100 to 300, a decrease in CNR of 28%, a slight decrease in spatial resolution accompanied with an increase in noise.

This study has shown that despite the increase in noise at low tube voltages, it is possible to reduce the dose without affecting the quantities of spatial resolution and the contrast/noise ratio by lowering the tube voltage from 120KVp to 100KVp.

Keywords: Abdominal CT; CTDIv; Image Quality; Phantom.
Molecular diagnosis of Duchene Muscular dystrophy
Authors: Berrada Sarah , Tazzite Amal , Dehbi Hind
Published: February 2022

Dystrophinopathies are the most common forms of muscular dystrophy in childhood, characterize by a progressive muscle weakness. Mutations in the DMD gene result in Duchenne Muscular Dystrophy (DMD) or Becker Muscular Dystrophy (BMD), inherited in X-linked recessive mode with a frequency of 1 in 3500 live born males. The present retrospective study aims to describe the mutation spectrum of DMD gene observed in 19 boys with muscular dystrophy without any clinical or familial information addressed to our laboratory between 2016 and 2020.  Mutation analysis was performed by PCR multiplex using a primer set of Chamberlain and Beggs. DNA was extracted from peripheral blood and PCR products were separated on 1% agarose gel and detected in U.V light after ethidium bromide staining.  The DMD gene is the largest human gene (2.4Mb) on Xp2. It consists of 79 exons encoding for dystrophin. Deletions were observed in 60% of patients, especially in the exons 3–7 and 44–55. To discern between the DMD and DMS diseases we can use a clinical approach or immunohistochemistry techniques. However, the protein-based strategy followed by molecular analysis is probably the most efficient way to approach diagnosis and to propose a correct genetic counselling. 

Keywords: Dystrophinopathies, Polymerase chain reaction, Duchene Muscular Dystrophy, Becker Muscular Dystrophy.
Assessment of the impact of anxiety and depression disorders on the quality of life of hemodialysis patients
Authors: Touil Driss , Ahami Ahmed .O.T
Published: February 2022

Patients with high anxiety or depression express low physical and mental quality of life, more symptoms and problems related to the disease, the effects of kidney disease more present in their daily lives and a greater sense of burden. This relationship between anxiety/depression and quality of life led us to conduct a study to identify the impact of anxiety and depression disorders on quality of life in haemodialysis patients. This cross-sectional descriptive study was conducted on a sample of 70 patients in the dialysis unit in Regional hospital center of Kenitra. Using psychiatric assessment scales: The Hospital Anxiety and Depression Scale to assess anxiety and depression and the KDQOL scale to assess quality of life, the results obtained are as follows: The mean age was 51.66±15.96 years. The average length of time on haemodialysis was 5.20±3.23 years. The study found a significant correlation between the patient's "effect of kidney disease on daily life" domain and anxiety, and a significant correlation of depression with the patient's "physical and psychological health", "kidney disease symptoms" and "effect of kidney disease on daily life" domains.This impact of anxiety and depression on quality of life makes the prevention of the risks of anxiety and depression disorders a necessity for improving the quality of life of haemodialysis patients.

Keywords: hemodialysis -anxiety -depression -quality of life -Kenitra
Neurological manifestations in Tuberous Sclerosis Complex
Authors: Bouzroud Wafaa , Berrada Sarah , Ibenbrahim Youssra , Maarouf Fatima , Tazzite Amal , Dehbi Hind
Published: February 2022

Tuberous Sclerosis Complex (TSC) is a rare multisystemic neurocutanous autosomal dominant syndrome. The cause of this disorder is a germinal mutation in TSC1 or TSC2 genes. Here, we report a case of a patient presenting tuberous sclerosis complex with TSC2 gene mutation. Our patient is aged 2 years and 6 months old, youngest of two siblings from a non-related marriage. The symptoms are neonatal hypotonia, epilepsy, psychomotor retardation, intellectual deficiency, dolichocephaly, above-average height, facial dysmorphia, and diffuse achromic spots on the chest and abdomen. The family survey found multiple siblings with various symptoms such as bony deformities, epilepsy, language delay, partial deafness, congenital renal malformation, and intellectual disability. The patient's brain MRI showed areas of cortico-subcortical hypodensity and subependymal nodules. The exome sequencing has detected a probably pathogenic heterozygous nonsense variant in the TSC2 gene: NM_000548.3: c.965C>A p.(ser322*). The variant identification was not performed in the parents due to lack of resources. TSC1 and TSC2 genes encode for hamartin-tuberin complex. Mutations in these genes cause hyperactivation of the mTOR pathway leading to the tumor development in several organs including the brain. The neurological manifestations of TSC can be epilepsy, intellectual deficiency, autism and behavioral disorders. The epilepsy is considered the main neurological symptom found in 70-90% of cases. Moreover, mutations in the TSC2 gene lead to severe epilepsy compared to TSC1 mutation.  The TSC is a disorder with an important neurological component. Investigations of epilepsy, brain MRI and genetic analysis may play an essential role in TSC diagnosis.

Keywords: Tuberous Sclerosis Complex, Neurology, Genetic mutation, TSC2.
Fragile X Syndrome: role of the FMR1 gene in neurodevelopmental disorders
Authors: Ibenbrahim Youssra , Bouzroud Wafaa , Berrada Sarah , Maarouf Fatima , Tazzite Amal , Dehbi Hind
Published: February 2022

Fragile X syndrome (FXS) is a multisystem disorder characterized by a large clinical spectrum including neuropsychological and behavioral disturbances such as intellectual deficiency (ID), global developmental delay, seizures and autism spectrum disorders (ASD). This syndrome is the result of a full mutation of the FMR1 gene. Here, we report the case of two patients with FXS.

Patient 1 is a 9-years-old child with ID, psychomotor developmental delay and facial dysmorphia. The family survey found a history of school failure in maternal uncle and cousin. FMR1 gene analysis identified pre-mutation and full mutation.

Patient 2, aged 10, presents ID, epilepsy, absence of language, psychomotor retardation, behavioral disorder and facial dysmorphia. The brothers and three maternal cousins have ID. FMR1 gene analysis revealed full mutation.

The FMR1 gene, located on Xq27.3, is involved in the development and maintenance of neural circuits essential for cognitive functions. FMR1 encodes the fragile X mental retardation protein (FMRP). This protein has a local role in synaptic plasticity, dendrite and axon development, and underlying learning and memory. The trinucleotide repeat expansions inactivate the FMR1 gene leading to the absence of FMRP and RNA/proteins dysregulation that causes alterations in synaptic connectivity clearly observed in FXS patient brains and a decrease in the number of dendrites and spines. FXS research emerged as a model of translational neuroscience. Therefore, deeper knowledge of FMRP functions would lead to rational therapeutic approaches. Furthermore, understanding the role of FMRP at synapses offers hope for the treatment of other ASD affecting learning and behavior.

Keywords: X Fragile Syndrome, FMR1, FMRP, Neurodevelopmental disorders.
Particle emissions from a modern heavy-duty diesel engine as ice nuclei in immersion freezing mode: a laboratory study on fossil and renewable fuels
Authors: Korhonen Kimmo , Kristensen Thomas Bjerring , Falk John , Malmborg Vilhelm B. , Eriksson Axel , Gren Louise , Novakovic Maja , Shamun Sam , Karjalainen Panu , Markkula Lassi , Pagels Joakim , Svenningsson Birgitta , Tunér Martin , Komppula Mika , Laaksonen Ari , Virtanen Annele
Published: February 2022

Abstract. We studied ice-nucleating abilities of particulate
emissions from a modern heavy-duty diesel engine using three different types
of fuel. The polydisperse particle emissions were sampled during engine
operation and introduced to a continuous-flow diffusion chamber (CFDC)
instrument at a constant relative humidity RHwater=110 %, while
the temperature was ramped between −43 and −32 ∘C (T scan). The
tested fuels were EN 590 compliant low-sulfur fossil diesel, hydrotreated
vegetable oil (HVO), and rapeseed methyl ester (RME); all were tested without
blending. Sampling was carried out at different stages in the engine exhaust
aftertreatment system, with and without simulated atmospheric processing
using an oxidation flow reactor. In addition to ice nucleation experiments,
we used supportive instrumentation to characterize the emitted particles for
their physicochemical properties and presented six parameters. We found that
the studied emissions contained no significant concentrations of ice-nucleating particles likely to be of atmospheric relevance. The substitution
of fossil diesel with renewable fuels, using different emission
aftertreatment systems such as a diesel oxidation catalyst, and
photochemical aging of total exhaust had only minor effect on their
ice-nucleating abilities.
Minimal CMIP Emulator (MCE v1.2): a new simplified method for probabilistic climate projections
Authors: Tsutsui Junichi
Published: February 2022

Abstract. Climate model emulators have a crucial role in assessing
warming levels of many emission scenarios from probabilistic climate
projections based on new insights into Earth system response to CO2
and other forcing factors. This article describes one such tool, MCE, from
model formulation to application examples associated with a recent model
intercomparison study. The MCE is based on impulse response functions and
parameterized physics of effective radiative forcing and carbon uptake over
ocean and land. Perturbed model parameters for probabilistic projections are
generated from statistical models and constrained with a Metropolis–Hastings
independence sampler. Some of the model parameters associated with
CO2-induced warming have a covariance structure, as diagnosed from
complex climate models of the Coupled Model Intercomparison Project (CMIP).
Perturbed ensembles can cover the diversity of CMIP models effectively, and
they can be constrained to agree with several climate indicators such as
historical warming. The model's simplicity and resulting successful
calibration imply that a method with less complicated structures and fewer
control parameters offers advantages when building reasonable perturbed
ensembles in a transparent way. Experimental results for future scenarios
show distinct differences between CMIP-consistent and observation-consistent
ensembles, suggesting that perturbed ensembles for scenario assessment need
to be properly constrained with new insights into forced response over
historical periods.
Surveying the Surveyors to Address Risk Perception and Adaptive Behaviour Cross-study Comparability
Authors: Rufat Samuel , Madruga de Brito Mariana , Fekete Alexander , Comby Emeline , Robinson Peter J. , Armaș Iuliana , Botzen Wouter J. W. , Kuhlicke Christian
Published: February 2022

Abstract. One of the key challenges for risk, vulnerability, and resilience research is how to address the role of risk perceptions and how perceptions influence behaviour. It remains unclear why people fail to act adaptively to reduce future losses, even when there is ever richer information available on natural and human-made hazards (flood, drought, etc.). The current fragmentation of the field makes it an uphill battle to cross-validate the results of existing independent case studies. This, in turn, hinders comparability and transferability across scales and contexts and hampers recommendations for policy and risk management. To improve the ability of researchers in the field to work together and build cumulative knowledge, we question whether we could agree on (1) a common list of minimal requirements to compare studies, (2) shared criteria to address context-specific aspects of countries and regions, and (3) a selection of questions allowing for comparability and long-term monitoring. To map current research practices and move in this direction, we conducted an international survey – the Risk Perception and Behaviour Survey of Surveyors (Risk-SoS). We find that most studies are exploratory in nature and often overlook theoretical efforts that would enable the comparison of results and an accumulation of evidence. While the diversity of approaches is an asset, the robustness of methods is an investment. Surveyors report a tendency to reproduce past research design choices but express frustration with this trend, hinting at a turning point. To bridge the persisting gaps, we offer several recommendations for future studies, particularly grounding research design in theory, improving the formalisation of methods, and formally comparing theories and constructs, methods and explanations while collecting the most-in-use themes and variables and controlling for the most-in-use explanations.
Evidencia sobre las vacunas para COVID-19 en niñas, niños y adolescentes
Authors: Risso Agostina , Chiaborelli Malena , Ciapponi Agustin
Published: February 2022

En Argentina, tres de las vacunas contra el COVID-19 autorizadas por la entidad regulatoria local se aplican en menores de edad: la vacuna desarrollada por Sinopharm (BBIBP-CorV) para niños de 3 años o más, y las desarrolladas por Moderna (ARNm 1273) y Pfizer (BNT162b2) a partir de los 12 años. Dado que estas recomendaciones no coinciden exactamente con las emitidas por diferentes organismos internacionales y debido al corto plazo de seguimiento de los ensayos publicados, surgieron dudas fundamentalmente en relación a su seguridad. En este artículo, los autores sintetizan la evidencia disponible hasta el momento sobre las vacunas aplicadas en niños, niñas y adolescentes en nuestro país, basada en informes preliminares de ensayos clínicos y reportes de vigilancia epidemiológica.
Cartafol de poesía, de Celso Emilio Ferreiro. La verdadera historia de una obra minúscula
Authors: Dasilva Fernández Xosé Manuel
Published: February 2022

En este artículo se abordan los problemas que presenta Cartafol de poesía, iniciativa literaria de Xosé Velo y Celso Emilio Ferreiro de la que se posee una percepción poco clara aún hoy en día. Tales problemas afectan fundamentalmente a su configuración, de contornos imprecisos, y a la fecha de publicación, 1935 o 1936. Inicialmente se estudia la recepción de Cartafol de poesía antes de la Guerra Civil y en el período posterior al conflicto bélico. Después se examinan, por una parte, los testimonios de Celso Emilio Ferreiro relativos a este título y, por otra, la presencia del mismo en las ediciones sucesivas de su obra. Realizadas estas labores, se arroja luz sobre la historia de Cartafol de poesía en el contexto de la producción poética del autor de Celanova antes de 1936. Las dos conclusiones que se alcanzan, a partir de la comparación de tres ejemplares originales, es que Cartafol de poesía se trata de una obra minúscula constituida por unas tapas de cartulina para guardar paulatinamente una colección de poemas, de la cual solo se distribuirían dos, que tiene como fecha la primera mitad del año 1936.
O libro da filla ou a promesa da (in)felicidade segundo Inma López Silva
Authors: Moszczyńska-Dürst Katarzyna
Published: February 2022

O obxectivo deste artigo consiste en analizar a representación da (in)felicidade performativa, cos seus mandatos, promesas, tabús e fracasos, tal como quedou codificada en O libro da filla (2020), a última novela ata a data da escritora galega Inma López Silva. Partindo da teoría crítica das emocións elaborada por Sara Ahmed en La promesa de la felicidad (2019), veremos como os personaxes do texto analizado asocian a felicidade con determinados roles sociais, lugares, rituais ou estilos de vida, ou, incluso con determinadas maneiras de ver e vivir o mundo. Estes “obxectos felices” sonlles impostos pola lóxica cultural dominante como garantes da “boa vida” e “guións” de conduta normativa. Do mesmo xeito, comprobaremos de que maneira e baixo que condicións sociais o fomento da feliz normatividade oculta os “mecanismos psíquicos do poder” e provoca o xurdimento da melancolía. Por último, a análise de O libro da filla revelará o potencial político que radica nos arquivos da infelicidade e na escritura.
Escola, ressignificação, descolonização: narrativas de estudantes Kaingang na fronteira Sul do Brasil
Authors: Vicenzi Renilda , Picoli Bruno Antonio
Published: February 2022

Este artigo mobiliza narrativas de estudantes indígenas de comunidades Kaingang localizadas no Noroeste do Rio Grande do Sul e Oeste catarinense, realizadas em ambiente universitário, quando estudantes de Graduação na Universidade Federal da Fronteira Sul – campus Chapecó rememoraram suas experiências escolares na Educação Básica em escolas indígenas e/ou em escolas não indígenas. Problematiza-se a escola, a hegemonia epistemológica eurocêntrica e as possibilidades de que um grupo étnico vítima de epistemicídio e de genocídio se aproprie dessa instituição e, ao fazer isso, transforme-a em um lugar de “tempo liberto”, de proteção e de reafirmação de si, como um lugar de descolonização. Procura-se contribuir na reflexão sobre o acesso aos processos educacionais formais de estudantes indígenas e os significados da escolarização com vistas à preservação de suas origens, cultura na perspectiva de uma educação para a pluralidade e para a alteridade balizada pela literatura descolonial e crítica.
A imprensa internacional e a crítica folhetinesca aos espetáculos: um entrecruzamento de leituras da série “Semana Lírica” (1846-1847), de Martins Pena
Authors: Gimenez Priscila Renata
Published: February 2022

O folhetim sobre o teatro lírico foi uma seção de muito sucesso nos periódicos desde a primeira metade do século XIX. No Brasil, entre 1846 e 1847, Martins Pena produziu a série “Semana Lírica”, no rodapé do Jornal do Commercio. Vilma Arêas (1987), estudiosa da obra do comediógrafo, inaugura o estudo específico desses folhetins, explanando desde seu conteúdo ao estilo do folhetinista. Pretende-se, neste estudo, levantar os principais pontos abordados por Arêas, aprofundando e complementando a análise da elaboração crítica de Pena, observando seus procedimentos e métodos à luz das práticas folhetinescas da imprensa transnacional.
Uma Proposta de Modelo Metacognitivo de Aquisição da Escrita no Ensino Universitário Moçambicano
Authors: Ernesto Nelson Maurício
Published: February 2022

A metacognição sempre esteve presente nos modelos processuais de produção escrita (ROHMAN, 1965 FLOWER; HAYES, 1980 BEREITER; SCARDAMALIA, 1987), com destaque à presença de estratégias de aprendizagens (metacognitivas) que auxiliam a produção textual, através de uma frequente monitorização e autorregulação da cognição na produção textual. Este artigo propõe um modelo metacognitivo de tratamento da escrita, tomando em consideração que a aprendizagem da escrita também circunscreve-se ao ensino universitário, assumindo também que um ótimo produtor de escrita é o que faz uso das estratégias metacognitivas no desenvolvimento da produção escrita, o que não é operado pelo produtor de escrita menos eficiente.
Abordagens cognitivistas na aquisição da língua escrita: revisitando O mapa do pezinho
Authors: Silva Leosmar Aparecido da , Cerqueira Mirian Santos de , Rauber André Luiz
Published: February 2022

Este estudo tem como objetivo revisitar, teórica e metodologicamente, o artigo intitulado “Aquisição da escrita: a construção textual em O mapa do pezinho”, de Rauber (2008). Para isso, toma como ponto fundamental as abordagens cognitivistas para o estudo da aquisição da língua escrita, tanto numa perspectiva baseada no uso (funcionalista) quanto noutra de viés mentalista (gerativista). A metodologia utilizada para a realização deste trabalho concentra-se na análise qualitativa de um texto produzido por uma criança em idade escolar. Os resultados mostraram que, independentemente das divergências quanto ao processo de desenvolvimento da linguagem escrita, as ciências cognitivas ancoradas no gerativismo e no funcionalismo têm muito a contribuir para os estudos sobre a aprendizagem da escrita.
PENGARUH PEMBERIAN EKSTRAK CIPLUKAN (Physalis angulata L.) TERHADAP JUMLAH FIBROBLAS PADA IMIQUIMOD-IN DUCED PSORIASIS MICE MODEL
Authors: Musa Irse Priyaganda Bani , Sylviningrum Thianti , Novrial Dody , Salman Muhamad
Published: February 2022

Imiquimod menginduksi terjadinya aktivasi sel Th17 dan sel dendritik yang berperan dalam terjadinya psoriasis. Ekstrak ciplukan ( Physalis angulata L.) mengandung senyawa steroid, flavonoid, alkaloid, dan saponin seperti Physalin B, Physalin F, Physalin G yang memiliki aktivitas antiinflamasi dalam patofisiologi psoriasis. Penelitian ini merupakan penelitian eksperimental dengan post test only with control group design. Tiga puluh lima ekor mencit betina dibagi dalam 7 kelompok. Kelompok A: kontrol negatif, kelompok B: kontrol positif, kelompok C yang diinduksi imiquimod dan diberikan ekstrak ciplukan 400 mg/kgBB selama 7 hari, kelompok D yang diinduksi imiquimod dan diberikan ekstrak ciplukan 800 mg/kgBB selama 7 hari , kelompok E yang diinduksi imiquimod dan diberikan ekstrak ciplukan 1.200 mg/kgBB selama 7 hari, kelompok F yang diinduksi imiquimod dan diberikan methotreksat 1 mg/kgBB selama 7 hari, dan kelompok G yang diinduksi imiquimod dan diberikan kombinasi ekstrak ciplukan 1.200 mg/kgBB dan methotreksat 1mg/kgBB selama 7 hari. Jumlah sel fibroblas dihitung pada hari ke lima belas dengan mengambil sampel kulit mencit dan dilakukan pembuatan preparat histologi kemudian dihitung secara manual menggunakan mikroskop. Rerata jumlah sel fibroblas pada kelompok A,B,C,D,E,F,dan G masing- masing adalah 21,6±2,3; 39,2±5,5; 30,6±1,3; 24,0±2,8; 24,8± 2,9; 28,4±3,0;28,2±3,2. Hasil uji One Way ANOVA menunjukkan nilai p=0,000(p<0,05) sehzingga menunjukkan hasil signifikan.
PERFORMANCE AND FORECAST OF INDONESIAN RUBBER EXPORTS TO THE CENTRAL EUROPEAN COUNTRIES
Authors: Nugroho Agus Dwi , Prasada Imade Yoga , Lakner Zoltan
Published: February 2022

The price and consumption of rubber experienced a decline due to the global economic crisis, the US-China trade war, and coronavirus. This situation is unprofitable for Indonesia, and it must develop new target markets. Central Europe is one of the potential markets for Indonesian rubber. This study aims to ascertain the performance of the Indonesian rubber exports to Central European countries and forecast its future. The research used Indonesian rubber export data to Hungary, Poland, and Romania from January 1999 to March 2021. Descriptive statistics and autoregressive integrated moving averages were used to analyze the data. In the last three decades, Indonesian rubber exports to Central Europe have risen. The short-term forecasting indicates that Indonesian rubber exports to Poland will increase; on the other hand, exports to Romania will experience a decline. Meanwhile, exports to Hungary were relatively stable. This result was obtained using ARIMA estimation with different models for each country, respectively ARIMA(1,0,5) in Poland, ARIMA(2,0,1) in Romania, and ARIMA(2,0,1) in Hungary.
Captación de energía limpia para el suministro eléctrico en la UNTELS
Authors: Vilchez Ochoa Guillermo Lorenzo
Published: February 2022

La finalidad de este proyecto es poder brindar a la Universidad Nacional Tecnológica de Lima Sur (UNTELS) dos fuentes de energía que puedan abastecer diversas actividades. Estas fuentes serán de energía limpia y de energía convencional. La fuente de energía renovable estará compuesta por un generador fotovoltaico y un inversor; este último trabajará de manera automática para interrumpir el uso de la energía convencional cuando se esté suministrando energía limpia. Así, este trabajo de investigación pretende evaluar el dimensionamiento y la viabilidad económica para poder suministrar energía limpia a la UNTELS. Para ello, se realizó la cuantificación de la energía limpia para las actividades en la UNTELS, se estimó la viabilidad del proyecto usando indicadores económicos y se analizó  la reducción de dióxido de carbono con el generador fotovoltaico. Con base en el desarrollo del proyecto, se puede afirmar que tener un sistema híbrido que aporte tanto energía convencional como energía limpia si es viable desde el punto de vista técnico y económico.
Perfiles asociados al nivel de ingreso laboral de los egresados universitarios – análisis multivariable de la encuesta nacional INEI 2014
Authors: PELAEZ OSORIO MARIO ROGELIO , MANCO CAYCHO MYRNA
Published: February 2022

Se realizaron los análisis de construcción de conglomerados, de correspondencias múltiples y de tablas cruzadas múltiples sobre la Encuesta Nacional a Egresados Universitarios del INEI. El objetivo fue relacionar las condiciones educativas con los niveles de ingreso laboral de profesionales universitarios. Los egresados se agruparon en 2 niveles socioeconómicos familiares (bajo y medio-alto) y en 3 categorías de ingreso laboral (bajo,  medio y alto). El nivel socioeconómico de la familia del egresado se utilizó como variable de control y determina de manera significativa los niveles de ingreso laboral de los egresados universitarios. El 73% del total de egresados conservan el mismo nivel económico de su familia. Se encontraron los perfiles educativos para cada uno de los 6 grupos resultantes. En el estrato socioeconómico bajo, el perfil del graduado universitario que logra obtener ingresos laborales medios o altos se determina por la carrera que eligió estudiar (ingeniería, tecnológica o de salud), pertenece al cuadro de méritos, estudia postgrado, ya tiene título profesional y que el primer empleo que logró se corresponde con su nivel de calificación. En el estrato socioeconómico alto, el perfil del graduado que logra obtener ingresos laborales altos, es muy similar al perfil del estrato bajo; sin embargo intervienen además la calidad excelente de infraestructura y servicios universitarios de su institución universitaria y el desarrollo de competencias profesionales, como el uso de software específico de su carrera.
Bioensayos de toxicidad aguda de extractos vegetales con Daphnia magna: un camino eficaz hacia el desarrollo sostenible
Authors: BRACHO PEREZ JULIIO CESAR , TACZA VALVERDE IGNACIO RUBÉN , VÁSQUEZ CASTRO JAVIER ALBERTO
Published: February 2022

La revalorización de la biodiversidad peruana utilizando extractos vegetales ricos en metabolitos secundarios para utilizarlos en el control de plagas requiere, en primera instancia, el conocimiento de su toxicidad ambiental para evitar el posible impacto ambiental y sus cadena tróficas que sin duda alguna es el camino requerido hacia el desarrollo sostenible. Por tal motivo, este trabajo de investigación tiene como objetivo evaluar la toxicidad de los extractos acuoso, etanólico y hexánico de tres especies vegetales provenientes de la Amazonía peruana: mucura (Petiveria alliacea), huito (Genipa americana) y teta de vaca (Solanum mammosum); a través de bioensayos de toxicidad aguda con Daphnia magna durante 48 h de exposición se determinaron los valores de concentración letal media (CL50). Los resultados obtenidos para cada especie vegetal y sus extractos respectivos fueron: P. alliacea (711.18, 255.50, 65.36) mg.L-1, G. americana (508.07, 154.35, 20.64) mg.L-1, S. mammosum (380.07, 90.59, 3.37) mg.L-1. Estos resultados permiten el empleo de las especies vegetales de manera efectiva para el desarrollo futuro de productos naturales para el control de plagas con el mínimo impacto ambiental.
ARTICULACIÓN DE LOS SISTEMAS DE GESTIÓN HSEQ EN LA EMPRESA SL RESEARCH COLOMBIA SAS.
Authors: Amador Pinilla Ariana Valentina , Sierra Varón Laura Camila , Trujillo  Suarez Juan David
Published: February 2022

El objetivo del presente trabajo es evidenciar el resultado de la investigación que se ha realizado entorno a la aplicación de diferentes herramientas diagnosticas que nos ayudaran a determinar el cumplimiento de la organización frente a un sistema de gestión de calidad, ambiental y seguridad y salud en el trabajo, adicional determinar las brechas de cumplimiento del modelo del sistema viable en la empresa SL RESEARCH COLOMBIA SAS, para de esta manera poder determinar las diferentes medidas que puede adoptar la organización para el mejoramiento e integración de cada uno de estos. Mediante la metodología y análisis de los resultados encontrados se identificaron falencias o fallas a mejorar en la organización basados en la evaluación de los requisitos legales de las normas en estudio, para de esta manera poder determinar un modelo y enfoque adecuado mediante planes de acción como propuesta de un sistema de gestión integrado HSEQ.
SISTEMA DE GESTIÓN INTELIGENTE PARA SUMINISTROS DE AGUA Y ENERGÍA ELÉCTRICA EN UN EDIFICIO MILITAR BASADO EN EL INTERNET DE LAS COSAS.
Authors: Cardenas Chavez Juan Carlos , Elkhy Berenice Raymundo Roque , Carrasco Valderrama Alan
Published: February 2022

Con el incremento de las tarifas de los suministros de agua y energía eléctrica, el tema del inadecuado uso de recursos en un edificio militar por parte de los usuarios ha recibido mucha atención. Con el objetivo de monitorear el entorno de las instalaciones del edificio militar, controlar los aparatos eléctricos para reducir el consumo de energía, controlar el dispensado de agua, y analizar el entorno y la utilización en la instalación, este documento desarrolla el sistema de gestión inteligente para suministros de agua y energía eléctrica en un edificio militar basado en el internet de las cosas. En este sistema, el conjunto de sensores tales como: módulos sensores para Arduino y tarjetas de sensores personalizadas, como también el conjunto de actuadores tales como: módulos actuadores para Arduino y tarjetas de actuadores se utiliza como conjunto básico del internet de las cosas. El modelo de almacenamiento lo establece la base de datos relacional MYSQL. Además de la aplicación móvil que servirá de interfaz de usuario. Los gastos de agua y energía eléctrica en el edificio militar se reducen hasta cierto punto y el desaprovechamiento de recursos en el edificio militar se reduce satisfactoriamente.
Distribution of Corynepteris Baily in Dobrudzha Coalfield, NE Bulgaria
Authors: Tenchov Yanaki
Published: February 2022

Most of the specimens of Corynepteris collected from the Dobrudzha Coalfield sequence are small parts of pinnae. Two species – C. angustissima and C. coralloides predominate. The habitat of Corynepteris had been studied for a long time. The genus occurs in several units of clastic sediments deposited under fluviatile conditions across the prospected part of the depression, but is absent above the coal seam m9 (middle Bolsovian). When the swamp conditions were restored briefly (coal seams n1–n4) or for a longer time (Gurkovo Formation) the genus did not resettle in the depression. The nearest basin with the genus Corynepteris presented at that time is in the Czech Republic, more than 800 km away, which was too far for an effective reintroduction of the genus to the Dobrudzha Coalfield. Spores of the genus range up into the Westphalian D coal seam n3.
METHODOLOGICAL APPROACHES AND THEIR USE IN STUDYING RADIOCARBON IN SOIL OF THE «EXPERIMENTAL FIELD» SITE
Authors: Raimkanova A. M. , Lyakhova O. N. , Aidarkhanova A. K. , Serzahnova Z. B.
Published: February 2022

The paper describes experimental works, based on liquid-scintillation method of determining 14С concentration. Methodological approaches were developed for radiocarbon analysis using Pyrolyser-6 Trio system for samples ignition and ashing. Accuracy of researches performed was assessed by means of analysis of certified radiocarbon standards. As the result of experimental activities, for the first time the quantitative data was obtained for 14С concentration in soil of the «Experimental Field» testing site of Semipalatinsk Test Site. Radiocarbon was found to have a non-uniform character of distribution at the territory researched. The highest concentration of the radionuclide was registered directly in the epicenters of surface nuclear tests.
DETERMINATION OF POLONIUM-210 IN URINE SAMPLES, RADIATION EXPOSURE ASSESSMENT
Authors: Umarova A. V. , Shatrov A. N. , Umarov M. A. , Shakenova Yu. A.
Published: February 2022

Based upon present ideas of physical-chemical properties of polonium and its up-to-date determination techniques, a technique of 210Po radiochemical determination in urine samples was developed followed by alpha-spectrometry. The technique was tested on 24-hour urine samples collected from the personnel of the branch “Institute of Radiation Safety and Ecology” RSE NNC RK. The range of 210Po absolute activity per a 24-hour urine sample was determined to be 1.8·10-3÷0.12 Bq. 210Po contribution to the total dose of personnel internal exposure was estimated to be equal to 0.3 mSv/year.
RADIATION DAMAGE TO BERYLLIUM UNDER LOW-TEMPERATURE NEUTRON IRADIATION
Authors: Orazgaliyev N. A. , Sapatayev Ye. Ye. , Kozhakhmetov Ye. A. , Dauletkhanov Ye. D. , Uazyrkhanova G. K.
Published: February 2022

In this work, to assess the radiation damage of beryllium under low-temperature neutron irradiation, samples from beryllium grade TShG-200 with an oxide phase concentration of about 1 wt % were studied, which were kept in the IVG.1M research reactor for a long time and were irradiated to fluences 0.8–4·1020 neut./cm2. Also, unirradiated original witness samples of the same brand were tested to compare the results.The aim was to establish the level of radiation degradation of beryllium samples during their tests in the IVG.1M reactor. Mechanical tests for three-point bending and tension were performed to determine the strength of beryllium samples, and their microhardness was also measured. To determine the degree of swelling of the beryllium samples their densities were measured by the method of hydrostatic weighing in the medium of distilled water.According to the results of short-term bending and tensile tests, it was found that the beryllium material after reactor irradiation softens in the range of 9.3–16.7%. And the results of measuring the microhardness showed an increase of up to 23%. Density results did not reveal swelling of the samples after low-temperature neutron irradiation.After mechanical tests, special studies of fractures and microstructural analysis were carried out, which did not reveal noticeable changes in the microstructure of beryllium after irradiation.
EXERGETIC ANALYSIS OF THE EFFICIENCY OF NPP OPERATING ON BINARY CYCLE
Authors: Sungatova T. S. , Stepanova O. A. , Yermolenko M. V. , Kassymov A. B.
Published: February 2022

The paper considers a scheme for increasing the efficiency of generating electricity at nuclear power plants based on the implementation of binary cycles. The energy and exergy analysis of the effectiveness of such cycles has been carried out. The main performance indicators are obtained. On the basis of exergy analysis the main sources of losses at nuclear power plants operating on a binary cycle have been obtained.
Gambaran Lama Hari Rawat Inap Pasien Covid-19 Berdasarkan Karakteristik Demografi, Klinis dan Hasil Laboratorium Pasien di Ruang Perawatan Covid-19 RSUD H. Boejasin Pelaihari Tahun 2021
Authors: Jamini Theresia
Published: February 2022

Corona virus (SARS-CoV-2) is a severe acute respiratory syndrome that moves quickly from human to human through direct contact which spreads so fast every day that the number of infected people continues to increase. Increased impact on length of stay, which is an indicator to determine hospital care, quality control, use of hospital services that can be assessed from various aspects. Find out the description the length of stay of covid-19 patients based on demographic, clinical and laboratory characteristics of patients in the medical ward of covid-19 H. Boejasin Pelaihari Hospital. This type of research is observational with retrospective descriptive design using with total sampling method. The number of samples is 208 medical record date of patients. Instruments for data collection of documentation sheets. Data analysis using frequency distribution table.The results showed that the number of days hospitalized for Covid-19 patients from all dominant characteristics was 14 days, the most cases were in the elderly 97 respondents (46.6%), gender of male 110 respondents (52.9%), had commorbid 125 respondents (60.1%), did not have fever when they entered the hospital, 130 respondents (62.5%), and low lymphocyte values 99 respondents (47.65%). The length of days of hospitalization for Covid-19 patients from all dominant characteristics is 14 days. More than patients whose length of stay is > 14 days.
أساليب الدعوة في حياة بعض الرسل و الأنبياء
Authors: حسن إبراهيم إبراهيم
Published: February 2022

أساليب الدعوة في حياة بعض الرسل و الأنبياء

This research (The methods of “Dawa” in the life of some prophets and messengers) is composed of introduction, three themes and a number of inquiries.

The first theme illustrated the concept of methods (linguistically and terminologically) and also the most important methods of “Dawa” of those prophets.

The second theme is concerned with the task or function of prophets and messengers, with a full illustration to their struggling in order to execute this task.

In the last theme there wfre some samples of these methods through studying the life of some prophets and messengers.
شروط المفسر في مقدمة الكشاف للإمام الزمخشري
Authors: محمد سليمان حيدر
Published: February 2022

شروط المفسر في مقدمة الكشاف للإمام الزمخشري

The most important conditions that occupied the talents of Qura’n Sciences of the commentators and the most important reason of putting these conditions is the great care of the savants of Islam about the Holy Qura’n which Alla, the Mighty, has promised to.

Many savants have written in this field and they have mentioned a number of conditions for competence to talk about Holy Qura’n and its interpretation.

One of those who were competent to this was the Imam Gar Alla Az zamakhshari who chose the most important tool of an interpreter is to be familiar with Arabic Language and to have the ability of eloquent extractions and literal constructions and there is no doubt he had been excellent in this field of eloquent interpretation where his interpetation “AlKashafT was considered as master in this respect
خضوع القرار الإداري لمبدأ المشروعية : دراسة قانونية فقهية مقارنة
Authors: عبد الإله عبد اللطيف محمد حامد
Published: February 2022

خضوع القرار الإداري لمبدأ المشروعية : دراسة قانونية فقهية مقارنة

The research sheds light on the problem of the administrative conducts concerned with administrative decisions one issues and the extent of their conformity to the legislations organising the work and acquiring the common interest and to what extent they should be sticked to.

The research tackles the definition of administrative decision and the concept of the principle of the legislation and the effect of deviation of the administrative authority .

The study attained several principles aiming at linking the administrative decision with the legal responsibility