bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementation of Novel Autochthonous Microencapsulated Strains of Lactiplantibacillus plantarum, Lactococcus lactis, and Lamb’s Rennet in the Production of Traditional “Paški Sir” Cheese
Authors: Kiš Marta , Zdolec Nevijo , Kazazić Snježana , Vinceković Marko , Jurić Slaven , Dobranić Vesna , Oštarić Fabijan , Marić Ivan , Mikulec Nataša
Published: May 2023

This study aimed to implement a microencapsulated form of selected autochthonous lactic-acid bacteria (LAB) isolated from the cheese-production chain and natural rennet obtained from suckling lambs in the traditional production of hard sheep cheese, “Paški sir”, from the island of Pag, Croatia. Two different formulations of microparticles were prepared: (i) microparticles containing the strain of both Lactiplantibacillus plantarum and Lactococcus lactis (S2) and (ii) microparticles containing both strains and natural rennet (S3). These formulations were used in the production of Paški sir cheese simultaneously with standard production using non-encapsulated commercial starter cultures and commercial rennet (S1). The number of Lc. lactis isolates decreased at day 30 and were not isolated during the remaining ripening process, whereas the number of L. plantarum remained stable throughout the ripening process. The level of LAB and the release of the rennet from microsphere formulations at the end allowed for the production of cheese with the same characteristics as the commercial product, indicating no negative interactions of natural rennet, bacterial culture, and chemical components of microparticles. To our knowledge, this is the first report of a microencapsulated L. plantarum (isolated from the abomasum of lambs) coupled with natural lamb’s rennet used in the production of hard sheep cheese. This pilot study showed the great potential for maintaining authenticity in cheese production by combining traditional and sustainable innovative technologies.
The Power Grid/Wildfire Nexus: Using GIS and Satellite Remote Sensing to Identify Vulnerabilities
Authors: Farnes Alyssa , Weber Keith , Koerner Cassie , Araújo Kathy , Forsgren Christopher
Published: May 2023

The effects of wildfire on the power grid are a recurring concern for utility companies who need reliable information about where to prioritize infrastructure hardening. Though there are existing data layers that provide measures of burn probability, these models predominately consider long-term climate variables, which are not helpful when analyzing current season trends. Utility companies need data that are temporally and locally relevant. To determine the primary drivers of burn probability relative to power grid vulnerability, this study assessed potential wildfire drivers that are both readily accessible and regularly updated. Two study areas in Idaho, USA with contrasting burn probabilities were compared. Wildfire drivers were obtained and differentiated between the study areas across the 2018–2021 growing seasons. This study determined that mean wind speed, cumulative growing season precipitation, and the mean Normalized Difference Vegetation Index (NDVI) for an area of interest may be reliable indicators of burn probability on a temporally relevant scale. This assessment demonstrates a method and variables that may be utilized by municipal electric utilities, electric cooperatives, and other power utilities to determine where to harden power grid infrastructure within wildfire-prone areas.
Effects of Annona muricata Extract on Trypsin, Cathepsin B and Collagenase Activities and Textural Changes in Chilled Macrobrachium rosenbergii
Authors: Ibrahim Amalina , Bakar Kamariah , Bakar Jamilah , Nirmal Nilesh Prakash , Ikhwanuddin Mhd , Karim Nurul Ulfah
Published: May 2023

Texture is an important sensory attribute for overall quality and consumer acceptance of prawns. However, texture is affected during cold storage due to the proteolytic activity of endogenous proteases, resulting in poor quality and a short shelf life. The objective of this study is to determine the inhibitory effects of Annona muricata leaves extract (AMLE) (0, 3, 10 and 20%) on the trypsin, cathepsin B and collagenase activities extracted from the cephalothorax of Macrobrachium rosenbergii. In addition, the textural changes in M. rosenbergii during 20 days of cold storage (4 °C) were also determined. M. rosenbergii were soaked in four different treatments: 0, 3, 10 and 20% AMLE and 1.25% sodium metabisulphate for 10 min at 4 °C. Protease activity was significantly (p < 0.05) reduced at 10 and 20% AMLE. Similarly, cathepsin B showed a significant (p < 0.05) low after treatment at 20% AMLE. The maximum inhibitory activity of trypsin was achieved at 20% AMLE and the standard inhibitor (Tosyl-L-lysyl-chloromethane hydrochloride (TLCK)) compared to the control. Whereas, the lowest collagenase activity was obtained at 20% AMLE compared to the control. These inhibitory effects further maintain the firmness of M. rosenbergii coated with 20% AMLE up to the eighth day of storage when compared to the control. Meanwhile, the highest penetration work was found in the M. rosenbergii coated with 20% AMLE at the twentieth day of storage. In conclusion, treatment at 20% AMLE could be used as a natural preservative to inhibit protease, trypsin and collagenase activity of M. rosenbergii and thus can maintain firmness for up to 8 days of storage.
Enological Suitability of Indigenous Yeast Strains for ‘Verdejo’ Wine Production
Authors: Vázquez Jennifer , Mislata Ana Maria , Vendrell Victor , Moro Carlos , de Lamo Sergi , Ferrer-Gallego Raúl , Andorrà Imma
Published: May 2023

The use of indigenous yeasts for the production of wines is a tool to defend the typicity of a particular region. The selection of appropriate indigenous yeasts ensures the maintenance of oenological characteristics by simulating spontaneous alcoholic fermentation (AF) while avoiding the risks of stuck or sluggish fermentations. In this study, autochthonous yeasts from Verdejo grape juice (Appellation of Origin Rueda) were selected, identified, and characterized to exploit the characteristics of the ‘terroir’. The fermentation capacity of seven strains was studied individually at the laboratory scale. The most suitable strains (Saccharomyces cerevisiae: Sacch 1, Sacch 2, Sacch 4, and Sacch 6) and Sacch 6 co-inoculated with Metschnikowia pulcherrima were characterized at the pilot scale. The fermentation kinetics, bioproduct release, volatile composition, and sensory profile of the wines were evaluated. Significant differences were found, especially in the aroma profile. In particular, Sacch 6 and Sacch 6 co-inoculated with M. pulcherrima produced higher amounts of ethyl esters and acetates and lower amounts of higher alcohols than the spontaneous AF. Wines inoculated with indigenous yeasts had higher sensory scores for fruit aromas and overall rating. The selection of indigenous yeasts improved the aroma of Verdejo wines and could contribute to determining the wine typicity of the wine region.
Advanced Smartphone-Based Identification of Transport Modes: Resilience under GNSS-Based Attacks
Authors: Munoz Diaz Estefania , Rubio Hernan Jose Manuel , Jurado Romero Francisco , Karite Aicha , Vervisch-Picois Alexandre , Samama Nel
Published: May 2023

One of the main challenges for ticketing in Mobility as a Service is the integration of the public and individual transport modes into a unified ticketing service. To realize this concept, a trustworthy identification of transport modes that is resilient to possible attacks is required. In this work, we propose two smartphone-based methods to seamlessly identify the use of trams, buses, subways, walking and bicycles, which are able to detect GNSS-based attacks and continue to provide a trustworthy identification of transport modes. We have recorded real-world measurements with commercial smartphones using the transport network in Munich and Paris. Our results show that it is possible to provide trustworthy identification of transport modes even when the system is under attack. In conclusion, in this work we demonstrate the vulnerability of smartphone-based ticketing to GNSS-based attacks, propose two methods to overcome this vulnerability and demonstrate the validity of our methods with real-world measurements.
Large-Scale Ejecta of Z CMa—Proper Motion Study and New Features Discovered
Authors: Liimets Tiina , Kraus Michaela , Cidale Lydia , Karpov Sergey , Marston Anthony
Published: May 2023

Z Canis Majoris is a fascinating early-type binary with a Herbig Be primary and a FU Orionis-type secondary. Both of the stars exhibit sub-arcsecond jet-like ejecta. In addition, the primary is associated with the extended jet as well as with the large-scale outflow. In this study, we investigate further the nature of the large-scale outflow, which has not been studied since its discovery almost three and a half decades ago. We present proper motion measurements of individual features of the large-scale outflow and determine their kinematical ages. Furthermore, with our newly acquired deep images, we have discovered additional faint arc-shaped features that can be associated with the central binary.
Gelation Time of Network-Forming Polymer Solutions with Reversible Cross-Link Junctions of Variable Multiplicity
Authors: Tanaka Fumihiko
Published: May 2023

The gelation time tg necessary for a solution of functional (associating) molecules to reach its gel point after a temperature jump, or a sudden concentration change, is theoretically calculated on the basis of the kinetic equation for the stepwise cross-linking reaction as a function of the concentration, temperature, functionality f of the molecules, and multiplicity k of the cross-link junctions. It is shown that quite generally tg can be decomposed into the product of the relaxation time tR and a thermodynamic factor Q. They are functions of a single scaled concentration x≡λ(T)ϕ, where λ(T) is the association constant and ϕ is the concentration. Therefore, the superposition principle holds with λ(T) as a shift factor of the concentration. Additionally, they all depend on the rate constants of the cross-link reaction, and hence it is possible to estimate these microscopic parameters from macroscopic measurements of tg. The thermodynamic factor Q is shown to depend on the quench depth. It generates a singularity of logarithmic divergence as the temperature (concentration) approaches the equilibrium gel point, while the relaxation time tR changes continuously across it. Gelation time tg obeys a power law tg−1∼xn in the high concentration region, whose power index n is related to the multiplicity of the cross-links. The retardation effect on the gelation time due to the reversibility of the cross-linking is explicitly calculated for some specific models of cross-linking to find the rate-controlling steps in order for the minimization of the gelation time to be easier in the gel processing. For a micellar cross-linking covering a wide range of the multiplicity, as seen in hydrophobically-modified water-soluble polymers, tR is shown to obey a formula similar to the Aniansson–Wall law.
Productive Psychoses: Views on Terrorism and Politics in Homeland
Authors: Houwen Janna
Published: May 2023

In the eight seasons of Showtime’s television show Homeland, leading character Carrie suffers from a bipolar disorder which repeatedly results in psychotic episodes. During these psychotic breakdowns, her grip on reality is disturbed by delusions. However, her psychotic disposition also leads to abilities and insights that make her a valuable agent in international secret agencies such as the CIA. This essay examines how the productivity of Carrie’s psychoses can be related to the political, military-industrial order within which she operates as a spy fighting terrorism and other threats to national and international security. What does the fact that a person suffering from psychoses is able to comprehend complex international political processes tell us about these processes and the context in which they occur? To answer this question, I turn to two scholars, both of whom have theorized subjectivity in relation to psychosis: psychoanalyst Jacques Lacan and philosopher Mauricio Lazzarato. The radically different notions of Lacan and Lazzarato lead to different interpretations of Homeland. However, although Lazzarato is a critical opponent of Lacanian psychoanalysis, I demonstrate that Lacan’s psychoanalytical ideas and Lazzarato’s machine theories can to some extent be read as complementary in an analysis of Homeland, for what the two distinct theorists have in common is that they both relate subjectivity to sign systems—to the emergence and assignment of meaning, as well as to the suspension and absence thereof. This paper argues that the psychoses of Homeland’s lead character produce political meanings because of the condition’s specific relation to meaninglessness.
Spiritual Needs of Older Adults Living with Dementia: An Integrative Review
Authors: Britt Katherine Carroll , Boateng Augustine C. O. , Zhao Hui , Ezeokonkwo Francesca C. , Federwitz Chad , Epps Fayron
Published: May 2023

Older adults living with dementia experience progressive decline, prompting reliance on others for spiritual care and support. Despite a growing interest in studying persons living with dementia (PLwDs), empirical evidence on the spiritual needs of PLwDs has not been synthesized. Using the Whittemore and Knafl method, this integrative review examined the literature from 2000 to 2022 on the spiritual care needs of PLwDs. We sought to identify characteristics of the spiritual needs of PLwDs and ways to address them. The ATLA Religion, CINAHL, PsycINFO, PubMed, and Socindex databases were used to search the literature, and 12 peer-reviewed articles met the inclusion criteria. Spiritual care needs varied across studies. Overall, findings support the importance of identifying PLwDs’ religious and spiritual backgrounds to inform person-centered care. Spiritual needs were identified as verbal and non-verbal expressions related to past meaning and religious and spiritual background and were not consistently addressed in care. Providers reported observing spiritual distress in the mild stage prompting the need for spiritual care. There is a great need for dementia-specific spiritual assessment tools and spiritual care interventions to support spiritual well-being in dementia care. Spiritual care involves facilitating religious rituals and providing spiritual group therapy and religious and spiritual activities.
Intervention to Increase Cervical Cancer Screening Behavior among Medically Underserved Women: Effectiveness of 3R Communication Model
Authors: Asare Matthew , Elizondo Anjelica , Dwumfour-Poku Mina , Mena Carlos , Gutierrez Mariela , Mamudu Hadii M.
Published: May 2023

Human Papillomavirus (HPV) self-sampling has the potential to increase Cervical Cancer Screening (CCS) and reduce the cervical cancer burden in Medically Underserved Women (MUW). However, interventions promoting self-sampling are limited. We examined the effectiveness of an intervention study in increasing CCS among MUW. We conducted a quasi-experimental intervention study. A face-to-face verbal approach was used to recruit MUW (n = 83, mean age 48.57 ± 11.02) living in a small city in the US. Behavioral intervention based on reframing, reprioritizing, and reforming (3R model) was used to educate the women about CCS in a group format. The women (n = 83) completed pre-and post-intervention assessments, and 10 of them were invited for follow-up interviews. The primary outcome was CCS uptake. Mixed methods analyses were conducted using a t-test for the primary outcome, PROCESS for mediation analysis, and NVivo for interview data. The majority of women (75%) completed self-testing. High-risk HPV among women was 11%, and of those, 57% followed up with physicians for care. We found that the significant increase in the women’s post-intervention screening behaviors was mediated by the increase in knowledge (Indirect Effect [IE] = 0.1314; 95% CI, 0.0104, 0.4079) and attitude (IE = 0.2167; 95% CI, 0.0291, 0.6050) scores, (p < 0.001). Interview analyses offered further explanations why MUW found the intervention messages acceptable (encourages proactive behavior), feasible (simple and easy to understand), and appropriate (helpful and informative). Barriers, including lack of trust and fear of results, were identified. The findings suggest that an intervention that combines the 3R model and self-sampling may increase CCS among MUW.
Aspects Regarding Sustainability among Private Dental Practitioners from Bucharest, Romania: A Pilot Study
Authors: Țâncu Ana Maria Cristina , Didilescu Andreea Cristiana , Pantea Mihaela , Sfeatcu Ruxandra , Imre Marina
Published: May 2023

Oral health professionals’ knowledge of sustainability is essential for promoting environmental protection in dental healthcare. This pilot study involved an online survey addressed to 70 dental private practitioners from Bucharest, Romania, to evaluate their awareness of the concept of sustainability in dentistry. The performed statistical analysis revealed that 41.4% of the participants were well aware of sustainability in dentistry, with older participants demonstrating significantly higher levels of such awareness (p = 0.001). Sustainability awareness among participants correlates positively with their knowledge of the negative environmental impacts of dental activity (p < 0.001) and with the concern for sustainable dentistry implementation in their workplace (p = 0.037). Improper biohazardous waste disposal was identified as the primary cause of negative environmental impact of dental practices by 87.1% of participants. Installing high energy-efficient dental equipment was selected as the most important action to implement sustainability in participants’ dental practices (64.3%). Overall, 51.4% of the participants reported that the COVID-19 pandemic had a medium impact on their dental activity in terms of sustainability. Our study found that participants have a moderate level of awareness regarding sustainability in dentistry, highlighting the need for education on sustainability for oral health professionals.
A Histogram Analysis of the Pixel Grayscale (Luminous Intensity) of B-Mode Ultrasound Images of the Subcutaneous Layer Predicts the Grade of Leg Edema in Pregnant Women
Authors: Ikuta Eri , Koshiyama Masafumi , Watanabe Yumiko , Banba Airi , Yanagisawa Nami , Nakagawa Miwa , Ono Ayumi , Seki Keiko , Kambe Haruki , Godo Taiki , Sakamoto Shin-ichi , Hara Yoko , Nakajima Akira
Published: May 2023

The technique most widely used to quantitatively measure leg edema is only a pitting edema method. It has recently become possible to digitize B-mode ultrasound images and accurately quantify their brightness using an image-analysis software program. The purpose of this study was to find new indices of the grade of leg skin, to study whether or not analyses of the subcutaneous layer of leg skin on ultrasound images using image-editing software program can be used to evaluate it and to digitize it. Images of 282 subcutaneous layers of leg skin in 141 pregnant women were obtained using a B-scan portable ultrasound device. Rectangular photographs (vertical: skin thickness; horizontal: width of probe) were obtained using an image-editing program, and the luminous intensity (pixel grayscale: 0–255) and thickness of the skin were calculated using a histogram. We investigated the correlation between these parameters and the grade of pitting edema (0–3). There was a significant positive correlation between the grade of pitting edema and the average luminous intensity value, its standard deviation, and the skin thickness (ρ = 0.36, ρ = 0.22, ρ = 0.51, p < 0.0001, respectively). In particular, there was strong positive correlation between the grade of pitting edema and both the total number of pixels in a rectangle × (multiplied by) the average luminous intensity value and the total number of pixels in a rectangle × the standard deviation of the average luminous intensity value (ρ = 0.58 and ρ = 0.59, p < 0.0001, respectively). We could quantitatively evaluate the grade of leg edema by analyzing ultrasound photographs of the subcutaneous layer of the leg skin using an image-editing software program and found new indices to digitize it.
Enhancement and Communication of Ancient Human Remains through VR: The Case Study of Sexual Dimorphism in the Human Skull
Authors: Manzollino Roberta , Malatesta Saverio Giulio , Avola Danilo , Cinque Luigi , Del Bove Antonietta , Leopardi Laura , Marini Marco Raoul
Published: May 2023

Over the last years, the exponential progress of technology introduced a broader population of researchers and developers to the use of Virtual Reality (VR) devices in numerous contexts, e.g., gaming, simulations, and culture dissemination. Recently, cultural heritage has also been supported by motivational experiences and other improvements designed explicitly for specific users (visitors, researchers, and domain experts). In this context, we propose a protocol within a digital environment, using innovative, non-invasive, and non-destructive methods for the technological enhancement, education, and dissemination of ancient human remains. The presented case study is focused on sexual dimorphism in the human skull; several 3D models are digitally generated from female and male skull references exploiting an algorithmic approach with statistical analysis, e.g., Principal Component Analysis (PCA); then, the models are made available in a virtual environment with a Head Mounted Display (HMD) and can also be interacted with via a touchless approach (hands-free). Tests conducted with segmented populations provided promising results.
Documenting COVID-19 for Posterity: A Review of the Types of Fitted Face Masks Worn in Albury (Australia)
Authors: Spennemann Dirk H. R.
Published: May 2023

As the COVID-19 pandemic begins to abate and national public health systems are treating the SARS-CoV-2 virus as endemic, many public health measures are no longer mandated but remain recommended with voluntary participation. One of these is the wearing of fitted face masks, initially mandated to contain, or at least slow, the spread of SARS-CoV-2, which is primarily transmitted via aerosols emitted while breathing, coughing, or sneezing. Although the habit of once wearing fitted face masks recedes into memory for much of the population, so does the knowledge of the various types of masks that were once en vogue. To create a record for the future, this paper provides the first comprehensive documentation of the nature and range of fitted facemasks that circulated during the COVID-19 pandemic.
Importance of Protected Areas by Brazilian States to Reduce Deforestation in the Amazon
Authors: Sousa Marcos V. L. , Melo Silas N. , Souza Juciana C. B. , Silva Carlos F. A. , Feitosa Yuri , Matias Lindon F.
Published: May 2023

Protected areas (PAs) help in strategies for maintaining biodiversity and inhibiting deforestation of the Amazon rainforest. However, there are few studies that evaluate the effectiveness of lands protected by states (or federation units). Our goal was to compare land use change over 35 years in state-level PAs with another area of protection, both in the Amazon of the Maranhão state, Brazil. We employed remote sensing techniques, the geographic information system (GIS), and statistical analysis with the use of analyses of covariance (ANCOVAS) to analyze the presence of the classes of land use and change in the PA. The results indicate that the state PAs were effective in preserving forest cover and decelerating grazing. The implications of the results are discussed in the context of supporting public policies at the state level for the protection of the Amazon.
Assessing Head Check Crack Growth by Eddy-Current Testing
Authors: Marschnig Stefan , Loidolt Markus , Knabl Dieter , Steinecker Alwine , Popp Reinhard
Published: May 2023

Managing head checks is a crucial task for an infrastructure manager as in case of deep cracks, rails can break and, thus, accidents might be the consequence. Many infrastructure managers use vehicle-mounted eddy-current testing for detecting cracks. This is sufficient for guaranteeing safe railway operation in applying a reactive maintenance regime removing cracks of a pre-defined depth. Moving this towards a predictive maintenance regime is only possible through assessing the crack growth. Establishing a stable deterioration function needs a sound data basis including a proper re-positioning of the test results of consecutive testing campaigns. This paper presents the results achieved from analysing the eddy-current testing campaigns of 10 years on a main line of the Austrian railway network and calculating a crack growth function as regression to field data. While it is possible to derive stable functions, the testing frequency needs to be shortened in order to move further to predictive maintenance.
Provisioning Australian Seed Carrot Agroecosystems with Non-Floral Habitat Provides Oviposition Sites for Crop-Pollinating Diptera
Authors: Davis Abby E. , Schmidt Lena Alice , Harrington Samantha , Spurr Cameron , Rader Romina
Published: May 2023

The addition of floral resources is a common intervention to support the adult life stages of key crop pollinators. Fly (Diptera) crop pollinators, however, typically do not require floral resources in their immature life stages and are likely not supported by this management intervention. Here, we deployed portable pools filled with habitat (decaying plant materials, soil, water) in seed carrot agroecosystems with the intention of providing reproduction sites for beneficial syrphid (tribe Eristalini) fly pollinators. Within 12 to 21 days after the pools were deployed, we found that the habitat pools supported the oviposition and larval development of two species of eristaline syrphid flies, Eristalis tenax (Linnaeus, 1758) and Eristalinus punctulatus (Macquart, 1847). Each habitat pool contained an average (±S.E.) of 547 ± 117 eristaline fly eggs and 50 ± 17 eristaline fly larvae. Additionally, we found significantly more eggs were laid on decaying plant stems and carrot roots compared to other locations within the pool habitat (e.g., on decaying carrot umbels, leaves, etc.). These results suggest that deploying habitat pools in agroecosystems can be a successful management intervention that rapidly facilitates fly pollinator reproduction. This method can be used to support future studies to determine if the addition of habitat resources on intensively cultivated farms increases flower visitation and crop pollination success by flies.
Editorial: Kinin 2022 Meeting, Annecy, France
Authors: Schmaier Alvin H. , Ghannam Arije , Drouet Christian
Published: May 2023

The Kinin 2022 meeting took place at the Imperial Palace, Annecy, France, from 5–8 June 2022 [...]
Rehabilitation of Gait and Balance in Cerebral Palsy: A Scoping Review on the Use of Robotics with Biomechanical Implications
Authors: Bonanno Mirjam , Militi Angela , La Fauci Belponer Francesca , De Luca Rosaria , Leonetti Danilo , Quartarone Angelo , Ciancarelli Irene , Morone Giovanni , Calabrò Rocco Salvatore
Published: May 2023

Cerebral palsy (CP) is a congenital and permanent neurological disorder due to non-progressive brain damage that affects gross motor functions, such as balance, trunk control and gait. CP gross motor impairments yield more challenging right foot placement during gait phases, as well as the correct direction of the whole-body center of mass with a stability reduction and an increase in falling and tripping. For these reasons, robotic devices, thanks to their biomechanical features, can adapt easily to CP children, allowing better motor recovery and enjoyment. In fact, physiotherapists should consider each pathological gait feature to provide the patient with the best possible rehabilitation strategy and reduce extra energy efforts and the risk of falling in children affected by CP.
Impact of Invasive Pulmonary Aspergillosis in Critically Ill Surgical Patients with or without Solid Organ Transplantation
Authors: Dubler Simon , Etringer Michael , Weigand Markus A. , Brenner Thorsten , Zimmermann Stefan , Schnitzler Paul , Budeus Bettina , Rengier Fabian , Kalinowska Paulina , Hoo Yuan Lih , Lichtenstern Christoph
Published: May 2023

Background: Critically ill patients, especially those who have undergone solid organ transplantation (SOT), are at risk of invasive pulmonary aspergillosis (IPA). The outcome relevance of adequately treated putative IPA (pIPA) is a matter of debate. The aim of this study is to assess the outcome relevance of pIPA in a cohort of critically ill patients with and without SOT. Methods: Data from 121 surgical critically ill patients with pIPA (n = 30) or non-pIPA (n = 91) were included. Cox regression analysis was used to identify risk factors for mortality and unfavourable outcomes after 28 and 90 days. Results: Mortality rates at 28 days were similar across the whole cohort of patients (pIPA: 31% vs. non-pIPA: 27%) and did not differ in the subgroup of patients after SOT (pIPA: 17% vs. non-pIPA: 22%). A higher Sequential Organ Failure Assessment (SOFA) score and evidence of bacteraemia were identified as risk factors for mortality and unfavourable outcome, whereas pIPA itself was not identified as an independent predictor for poor outcomes. Conclusions: Adequately treated pIPA did not increase the risk of death or an unfavourable outcome in this mixed cohort of critically ill patients with or without SOT, whereas higher disease severity and bacteraemia negatively affected the outcome.
A Case Report of Pediatric Patient with Tuberous Sclerosis and Radiologically Isolated Syndrome
Authors: Sforza Giorgia , Monte Gabriele , Voci Alessandra , Figà Talamanca Lorenzo , Papetti Laura , Ferilli Michela Ada Noris , Proietti Checchi Martina , Valeriani Massimiliano , Moavero Romina
Published: May 2023

Introduction: Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous disease with central nervous system (CNS) involvement. Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the CNS characterized by symptomatic episodes that occur months or years apart and affect different anatomic locations. In the absence of symptomatic episodes, radiologically isolated syndrome (RIS) could be diagnosed. Here, we report the case of a 10-year-old boy followed-up for TSC and diagnosed with RIS after a routine neuroimaging assessment. Case description: The patient was diagnosed with TSC after seizure onset at the age of 4 years. The follow-up magnetic resonance imaging (MRI) showed multiple asymptomatic demyelinating lesions. Brain and spinal cord MRI was performed after 2 months and showed additional lesions in the right frontal white matter and left cerebral peduncle, the latter with contrast enhancement. Therefore, he received a diagnosis of RIS. Visual evoked potentials were normal. Cerebrospinal fluid examination showed oligoclonal bands. The search for AQP4-IgG and MOG-IgG antibodies was negative. He was treated with interferon beta-1a. Six months later, follow-up MRI revealed no new demyelinating lesions and resolution of contrast enhancement. Conclusion: To the best of our knowledge, this is the third reported patient presenting a co-occurrence of TSC and demyelinating disease. Although we cannot state if the described comorbidity is casual or not, some clinical and preclinical data suggest that the mTOR complex might be the link between TSC and demyelinating disease.
Metrics of Gender Differences in Mortality Risk after Diabetic Foot Disease
Authors: Seghieri Giuseppe , Gualdani Elisa , Francia Piergiorgio , Campesi Ilaria , Franconi Flavia , Di Cianni Graziano , Francesconi Paolo
Published: May 2023

Background: The aim of this study was to clarify any gender differences in the mortality risk of people with DFD since patients with diabetic foot disease (DFD) are at a high risk of mortality and, at the same time, are more likely to be men. Methods: From regional administrative sources, the survival probability was retrospectively evaluated by the Kaplan-Meier method and using the Cox proportional-hazards model comparing people with DFD to those without DFD across the years 2011–2018 in Tuscany, Italy. Gender difference in mortality was evaluated by the ratio of hazard ratios (RHR) of men to women after initial DFD hospitalizations (n = 11,529) or in a cohort with prior history of DFD hospitalizations (n = 11,246). Results: In both cohorts, the survival probability after DFD was lower among women. Compared to those without DFD, after initial DFD hospitalizations, the mortality risk was significantly (18%) higher for men compared to women. This excess risk was particularly high after major amputations but also after ulcers, infections, gangrene, or Charcot, with a lower reduction after revascularization procedures among men. In the cohort that included people with a history of prior DFD hospitalizations, except for the risk of minor amputations being higher for men, there was no gender difference in mortality risk. Conclusions: In people with DFD, the overall survival probability was lower among women. Compared to those without DFD after a first DFD hospitalization, men were at higher risk of mortality. This excess risk disappeared in groups with a history of previous DFD hospitalizations containing a greater percentage of women who were older and probably had a longer duration of diabetes and thus becoming, over time, progressively frailer than men.
Adolescents’ Out-of-School Physical Activity Levels and Well-Being during the COVID-19 Restrictions in Greece: A Longitudinal Study
Authors: Lazaridis Alexandros , Syrmpas Ioannis , Tsatalas Themistoklis , Krommidas Charalampos , Digelidis Nikolaos
Published: May 2023

The present study aimed to identify the impact of social distancing measures on adolescents’ physical activity (PA) levels and well-being during the implementation of COVID-19 restrictive measures. There were 438 participants (207 boys and 231 girls), aged 12 to 15 years old (M = 13.5, SD = 0.55). They completed online questionnaires on well-being and PA in three waves (December 2020, February 2021, and June 2021). Correlation analyses were conducted to examine the relationship between well-being and PA variables in the three measurements. Additionally, separate three-way repeated-measures ANOVAs were conducted to capture possible differences in students’ moderate to vigorous physical activity (MVPA) levels, life satisfaction, and subjective vitality among the three measurements due to gender, age, and interaction between gender and age. A significant relation emerged between the MVPA variables and well-being. In all measurements, adolescents’ PA levels did not meet the World Health Organization (WHO) recommendations of at least 60 min per day in MVPA. Students’ MVPA levels, life satisfaction, and subjective vitality were significantly higher in the third measurement compared to the first and second ones. Moreover, significant differences emerged in life satisfaction and subjective vitality between boys and girls in the first and third measurements, respectively. The COVID-19 restrictions appeared to negatively influence adolescents’ PA and well-being. Policymakers aimed at facilitating adolescents’ well-being in a similar situation in the future should not adopt measures restricting the participation of adolescents in PA.
Biomechanical Analysis of the Unaffected Limb While Using a Hands-Free Crutch
Authors: Kim Jaewook , Kim Yekwang , Moon Juhui , Kong Joo , Kim Seung-Jong
Published: May 2023

Basic human ambulation relies on a bipedal gait, which has been reported to be directly related to quality of life. However, injuries to the lower limb can cause an inability to walk and require non-weightbearing periods to heal. Among the many ambulatory aids, standard axillary crutches are prescribed. However, due to the disadvantages of having to use both hands, a slow gait, pain, nerve damage, and gait patterns that differ from that of healthy subjects, currently, a new generation of ambulatory aids has emerged. Among such aids, hands-free crutches (HFCs) are of particular interest due to their form factor, which does not require the use of the hands and facilitates a bipedal gait. In this study, we present an assessment of whether any different gait patterns, compared to overground gait, appeared on the unaffected limb during walking with an HFC. The spatiotemporal parameters, plantar force, lower-limb joint angles, and EMG patterns were evaluated. In conclusion, the results from 10 healthy subjects suggest that wearing an HFC causes only slight changes in the biomechanical gait patterns examined in the unaffected limb compared with overground walking without an HFC.
Advances in Numerical Modeling of Coupled CFD Problems
Authors: Ryzhakov Pavel B. , Marti Julio , Hashemi Mohammad R.
Published: May 2023

The development and application of numerical models to the simulation of coupled CFD problems has been the focus of research in various areas of science and engineering since the first decade of the 21st century [...]
Low Lung Function Is Associated with Low Baseline Calcaneus Ultrasound T-Score but a Slow Decline in T-Score in a Taiwanese Follow-Up Population with No History of Smoking, Bronchitis, Emphysema, or Asthma
Authors: Tsai Yu-Lin , Wang Hao-Ping , Wu Da-Wei , Huang Jiun-Chi , Wu Pei-Yu , Chen Szu-Chia
Published: May 2023

Osteoporosis is a common disease, and the prevalence is increasing in patients with chronic respiratory diseases, with important implications with regard to fractures, hospitalization, and death. Due to inconsistent data and a lack of large cohort follow-up studies on the association between lung function and osteoporosis, the aim of this study was to investigate this issue. We enrolled and followed for a median of 4 years a total of 9059 participants with no history of smoking, bronchitis, emphysema, or asthma from the Taiwan Biobank. Spirometry data, including forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC), were used to assess lung function. Changes in the calcaneus ultrasound T-score (ΔT-score) were calculated as follow-up T-score—baseline T-score. A ΔT-score ≤ −3 (median value of ΔT-score) meant a fast decline in T-score. Multivariable analysis showed that lower values of FEV1 (β, 0.127, p < 0.001), FVC (β, 0.203, p < 0.001), and FEV1/FVC (β, 0.002, p = 0.013) were significantly associated with a low baseline T-score. In addition, after follow-up, higher values of FEV1 (odds ratio (OR), 1.146, p = 0.001), FVC (OR, 1.110, p = 0.042), and FEV1/FVC (OR, 1.004, p = 0.002) were significantly associated with ΔT-score ≤ −3. FEV1/FVC < 70% (OR, 0.838, p < 0.001) was significantly associated with ΔT-score ≤ −3. In conclusion, lower FEV1, FVC, and FEV1/FVC were associated with a low baseline T-score, and higher FEV1, FVC, and FEV1/FVC were associated with a rapid decline in T-score in follow-up. This suggests that lung disease may be associated with bone mineral density in the Taiwanese population with no history of smoking, bronchitis, emphysema, or asthma. Further research is needed to establish causality.
Difficult-to-Treat Pathogens: A Review on the Management of Multidrug-Resistant Staphylococcus epidermidis
Authors: Siciliano Valentina , Passerotto Rosa Anna , Chiuchiarelli Marta , Leanza Gabriele Maria , Ojetti Veronica
Published: May 2023

Multidrug-resistant Staphylococcus epidermidis (MDRSE) is responsible for difficult-to-treat infections in humans and hospital-acquired-infections. This review discusses the epidemiology, microbiology, diagnosis, and treatment of MDRSE infection and identifies knowledge gaps. By using the search term “pan resistant Staphylococcus epidermidis” OR “multi-drug resistant Staphylococcus epidermidis” OR “multidrug-resistant lineages of Staphylococcus epidermidis”, a total of 64 records have been identified from various previously published studies. The proportion of methicillin resistance in S. epidermidis has been reported to be as high as 92%. Several studies across the world have aimed to detect the main phylogenetic lineages and antibiotically resistant genes through culture, mass spectrometry, and genomic analysis. Molecular biology tools are now available for the identification of S. epidermidis and its drug resistance mechanisms, especially in blood cultures. However, understanding the distinction between a simple colonization and a bloodstream infection (BSI) caused by S. epidermidis is still a challenge for clinicians. Some important parameters to keep in mind are the number of positive samples, the symptoms and signs of the patient, the comorbidities of the patient, the presence of central venous catheter (CVC) or other medical device, and the resistance phenotype of the organism. The agent of choice for empiric parenteral therapy is vancomycin. Other treatment options, depending on different clinical settings, may include teicoplanin, daptomycin, oxazolidinones, long-acting lipoglycopeptides, and ceftaroline. For patients with S. epidermidis infections associated with the presence of an indwelling device, assessment regarding whether the device warrants removal is an important component of management. This study provides an overview of the MDRSE infection. Further studies are needed to explore and establish the most correct form of management of this infection.
Reconfiguration Analysis and Characteristics of a Novel 8-Link Variable-DOF Planar Mechanism with Five Motion Modes
Authors: Kong Xianwen , Wang Jieyu
Published: May 2023

Variable-DOF (or kinematotropic) mechanisms are a class of reconfigurable mechanisms that have varying degrees of freedom (DOF) in different motion modes and can be reconfigured without disassembly. However, the number of proposed variable-DOF multi-loop planar mechanisms is currently limited. This paper introduces a new 8-link variable-DOF planar mechanism that has five motion modes. Firstly, the 8-link variable-DOF planar mechanism is described. Then, reconfiguration analysis of the mechanism is performed using a hybrid approach that combines elimination and computer algebraic geometry methods. The analysis reveals that the 8-link mechanism has one 2-DOF motion mode and four 1-DOF motion modes. It can switch among three motion modes at four transition configurations and between two motion modes at the remaining four transition configurations. The paper also highlights the geometric characteristics of the mechanism in different motion modes. In contrast to variable-DOF planar mechanisms presented in the literature, the proposed 8-link mechanism has two inactive joints in one of its 1-DOF motion modes. Moreover, both closed-loop 4R kinematic sub-chains of the mechanism must appear as either a pair of parallelograms or a pair of anti-parallelograms in the same motion mode. As a by-product of this research, a method for factoring trigonometric functions in two angles is also proposed.
Diesel Engine Fault Prediction Using Artificial Intelligence Regression Methods
Authors: Viana Denys P. , de Sá Só Martins Dionísio H. C. , de Lima Amaro A. , Silva Fabrício , Pinto Milena F. , Gutiérrez Ricardo H. R. , Monteiro Ulisses A. , Vaz Luiz A. , Prego Thiago , Andrade Fabio A. A. , Tarrataca Luís , Haddad Diego B.
Published: May 2023

Predictive maintenance has been employed to reduce maintenance costs and production losses and to prevent any failure before it occurs. The framework proposed in this work performs diesel engine prognosis by evaluating the absolute value of the failure severity using random forest (RF) and multilayer perceptron (MLP) neural networks. A database was implemented with 3500 failure scenarios to overcome the problem of inducing destructive failures in diesel engines. Diesel engine failure signals were developed with the zero-dimensional thermodynamic model inside a cylinder coupled with the crankshaft torsional vibration model. Artificial neural networks and random forest regression models were employed for classifying and quantifying failures. The methodology was applied alongside an engine simulator to assess effectiveness and accuracy. The best-fitting performance was obtained with the random forest regressor with an RMSE value of 0.10 ± 0.03%.
On a New Characterization of Harris Recurrence for Markov Chains and Processes
Authors: Glynn Peter , Qu Yanlin
Published: May 2023

This paper shows that Harris recurrent Markov chains and processes can be characterized as the class of Markov chains and processes for which there exists a random time T at which the distribution of the chain or process does not depend on its initial condition. In particular, no independence assumptions concerning the post-T process or T play a role in the characterization. Since Harris chains and processes are known to contain infinite sequences of regeneration times exhibiting various independence properties, it follows that the existence of this single T implies the existence of infinitely many times at which regeneration occurs.
Erlang-Distributed SEIR Epidemic Models with Cross-Diffusion
Authors: Chebotaeva Victoria , Vasquez Paula A.
Published: May 2023

We explore the effects of cross-diffusion dynamics in epidemiological models. Using reaction–diffusion models of infectious disease, we explicitly consider situations where an individual in a category will move according to the concentration of individuals in other categories. Namely, we model susceptible individuals moving away from infected and infectious individuals. Here, we show that including these cross-diffusion dynamics results in a delay in the onset of an epidemic and an increase in the total number of infectious individuals. This representation provides more realistic spatiotemporal dynamics of the disease classes in an Erlang SEIR model and allows us to study how spatial mobility, due to social behavior, can affect the spread of an epidemic. We found that tailored control measures, such as targeted testing, contact tracing, and isolation of infected individuals, can be more effective in mitigating the spread of infectious diseases while minimizing the negative impact on society and the economy.
Application of Fuzzy PID Based on Stray Lion Swarm Optimization Algorithm in Overhead Crane System Control
Authors: Fu Jie , Liu Jian , Xie Dongkai , Sun Zhe
Published: May 2023

To solve the problem of crane anti-swing, fuzzy PID is a common method. However, the parameter configuration of fuzzy PID requires a lot of time and effort from professionals. Based on this, we introduce the LSO algorithm and add the stray operator, which effectively improves its global search performance. By combining SLSO and fuzzy PID and comparing them with other methods, this paper confirms that even without the targeted optimization by professionals, the optimization algorithm can find the appropriate parameter configuration for fuzzy PID which can be effectively used in the crane anti-swing problem.