bluuebunny/crossref_metadata_2025 huggingface dataset:
A survey of post-polypectomy colonoscopy surveillance knowledge among general practitioners.
Authors: Kobiela Jarek , Spychalski Piotr , Graff Krzysztof , Marek Iwona , Siebert Janusz , Adrych Krystian , Kobiela Paulina , Wieszczy Paulina , Reguła Jarosław , Kamiński Michał F.
Published: October 2019

Background
Screening has been shown to be effective in reducing CRC incidence and mortality. Adherence to the guidelines of surveillance after polypectomy is considered key. In most countries including Poland general practitioners (GPs) are responsible for referring patients for surveillance colonoscopy.
The aim of the study was to examine the knowledge of post-polypectomy surveillance among GPs in Poland.
Methods
We have designed five scenarios of post-polypectomy surveillance based on European guidelines adapted by the Polish Society of Gastroenterology. The scenarios described different risk groups based on the characteristics of the removed polyps requiring different time intervals of surveillance colonoscopy. They were supplemented with basic demographic data of the surveyed GP. The questionnaire was carried out by surveyors during a national congress of GPs.
Results
A total of 340 questionnaires were filled by GPs. None of the surveyed doctors gave correct answers in all questions. The knowledge of post-polypectomy surveillance is very unsatisfactory (correct answers 1.2%-55.0%). One year surveillance interval was the most commonly chosen interval regardless risk groups based on the characteristics of the removed polyps. In 4 of 5 scenarios the surveillance overuse ranged 42.1%-98.5%. In a high risk group scenario surveillance was underused in 45.0%.
Conclusions
Post-polypectomy surveillance schemes are not known to GPs with a significant trend towards overuse. Strict adherence to guidelines should be pursued to include written recommendation on surveillance program in the final endoscopy report. Efforts should be made by public health policy makers to increase knowledge of surveillance schemes among GPs.
Investigation on Intervention Effects of Applying Proton Pump Inhibitors in Inpatients
Authors: Qing Guotong , Wu Jian , Wei Runfong , Wu Di , Gou Yipping , Huonh Lizheng , Wu Shenjun , Jiesisibieke Zhu Liduzi , Chien Ching-Wen
Published: October 2019

Background. To investigate the intervention effect of clinical pharmacists on irrational use of proton pump inhibitors (PPIs) in clinicians. Methods. A cross-sectional study was used to through the hospital information management system survey, before intervention (July 15th, 2016, Aug 15th, 2016 and Sep 15th 2016) and dry prognosis (July 15th, 2017, Aug 15th, 2017 and Sep 15th, 2017) all the use of PPIs inpatients related information. According to the guidelines of "drug instructions" and "experts on stress ulcer prevention and treatment experts", the standard of drug use was formulated, and the use of PPIs before and after intervention was evaluated and analyzed in accordance with the standard, and the results of intervention were evaluated. Results. The total number of hospitalized patients surveyed before the intervention was 1,693, the average utilization rate of proton pump inhibitors was 27.05% and the coincidence rate was 52.40%. The total number of hospitalized patients investigated after the intervention was 2,095, the average utilization rate of proton pump inhibitors was 8.54%, and the coincidence rate was 68.16%. Before and after the intervention, there was no difference in gender ratio and age distribution, the decrease of the utilization rate and the improvements of the qualified rate after intervention were statistically significant.Conclusion. According to the standards of PPIs, clinical pharmacists strictly implement the special prescription review system and other intervention measures, which can significantly improve the level of PPIs rational clinical medication.
Evaluating Developmental Stages of Total Health Expenditures in China
Authors: jie Qiu lei , Li Xu , Wang Yan , Liu Qian , Ma Anning , Ma Guifeng
Published: October 2019

Objective This study evaluated developmental stages and trends of Total Healthcare Expenditure (THE) of 18 provinces in China. We explored characteristics of different development stages during healthcare expenditure, to provide scientific reference for China's healthcare policy making and regional healthcare planning.Methods Firstly, curve fitting and parameter estimation using SPSS21 software were carried out for the Logistic function model, and then the three-point or four-point method was applied to estimate the value of saturation K. Finally the Logistic function equation and fitting graph were obtained. According to the nature of Logistic curve, the study divided THE into three stages, gradual, rapid and slow growth, and predicted and analyzed THE developments in 18 provinces.Results By 2019, 15 provinces have entered a period of rapid THE growth. Regionally, the time to enter fast growth period early to late are in the order of northeast ( in 2005), east China ( in 2008), northwest ( in 2010), south China ( in 2013), north China ( in 2015) and southwest ( in 2015). The earliest province to enter rapid growth period is Liaoning province (in 2005), Shandong province enter the period at latest (in 2045). In 2027, all 18 provinces will enter the rapid growth period, and end in 2045. In this period, rapid growth in total health expense will last for about 23 years, with an average annual growth rate of 8.69%. Conclusions THE growth pattern is in line with typical trend of "slow-fast-slow" growth function. The expense developments vary between regions. Eastern region entered rapid and slow growth period later than the central and western regions. THE development stages and duration of the rapid growth period is correlated to regional economic level. The earlier it enters the fast growth period, the shorter it lasts, and vice versa. The government should take advantage of this period, from 2015 to 2029, to make policy preparations to respond THE rapid growth in China.
Exploring women’s perceptions of pain when breastfeeding using online methods
Authors: Caes Line , Abbott Katie , Currie Sinead
Published: October 2019

Background: Despite benefits, many mothers stop breastfeeding soon after birth. A common reason for this is the experience of pain or discomfort. One resource which women use to share their breastfeeding challenges and seek support are online forums. This study aimed to collect data from online forums to explore 1) usage of forums as social support for breastfeeding related pain; 2) experiences of breastfeeding related pain; 3) perceptions and strategies to deal with breastfeeding related pain; and 4) the impact of pain on breastfeeding duration. Methods : This secondary analysis of data involved searches of online forums: Netmums, What to Expect and Mumsnet using key terms including ‘ painful breastfeeding’ and ‘sore breastfeeding’ . Data included 123 posts and 193 replies, which were analysed using thematic analysis. Results: The first theme identified was ‘variation in types of pain’, highlighting the variety of painful experiences and their descriptions. Secondly, ‘perceived causes and explanations for pain’ revealed pain ascribed being due to a recognised condition or behavioural cause. The third theme ‘cessation of breastfeeding related to pain’ identified both physical and psychological struggles related to breastfeeding and cessation. Finally, ‘shared experiences and support’ identified practical or emotional support to deal with pain. Conclusion: Pain was a key reason for breastfeeding cessation, commonly associated with strong feelings of guilt. The online forums provide a unique form of social support for breastfeeding women to find ways to cope with the pain, while highlighting the urgent need for more appropriate antenatal education on realistic expectation surrounding breastfeeding.
Allogeneic human umbilical cord-derived mesenchymal stem cells for severe bronchopulmonary dysplasia in children: study protocol for a randomized controlled trial(the MSC-BPD Trial)
Authors: Wu Xian , Xia Yunqiu , Zhou Ou , Song Yan , Zhang Xianhong , Tian Daiyin , Li Qubei , Shu Chang , Liu Enmei , Yuan Xiaoping , He Ling , Liu Chengjun , Li Jing , Liang Xiaohua , Yang Ke , Fu Zhou , Zou Lin , Bao Lei , Dai Jihong
Published: October 2019

Background : Bronchopulmonary dysplasia (BPD) is a complex lung pathological lesion secondary to multiple factors, and one of the most common chronic lung diseases with poor prognosis, especially in preterm infants with severe BPD. However, there is lack of effective therapies for this disease. Stem cell therapy has been shown a promising way for improving lung injury and abnormal alveolarization, and human umbilical cord (hUC) is a good resource for mesenchymal stem cells (MSCs), which have demonstrated in some other diseases. We hypothesis that intravenous allogeneic hUC-MSCs is safe and effective for severe BPD.
Methods/design: The MSC-BPD trial is a randomized single-center open-label and dose-escalation phase II trial designed to investigate the safety and efficacy of hUC-MSCs in children with severe BPD. In this study, 48 patients will be enrolled and randomly divided into two intervention groups and one control group. Patients in the intervention groups will be receive a low dose of hUC-MSCs (n=16, 2.5 million cells/kg) or a high dose of hUC-MSCs (n=16, 5 million cells/kg) in combination with traditional supportive treatments for BPD. The patients in the control group (n=16) will be treated with traditional supportive treatments alone without receiving hUC-MSCs treatment. The primary outcome measures will be the cumulative duration of oxygen therapy. Follow-up assessments will be performed at 1, 3, 6, 12, 24 months after interventions, and the key outcome during follow-up will be the chest radiography changes. Statistical analyses will evaluate the efficacy of the hUC-MScs treatment.
Discussion: This study will be the first randomized controlled trial to evaluate the safety and efficacy of intravenous hUC-MSCs in children with severe BPD. Results of the trial will provide a new evidence-based therapy for severe BPD.
Trial registration: ClinicalTrials.gov, NCT03601416. Registered on 26th July 2018.
Key words: bronchopulmonary dysplasia, human umbilical cord-derived mesenchymal stem cells, clinical trial, protocol.
Examination of preterm babies for ROP referred to an eye department from an urban and semi-urban neonatal intensive care unit: implications for practice.
Authors: Venkatesh Ramesh , Dave Prachi Abhishek , Gurav Prachi , Agarwal Manisha , Jajoo Mamta , Gupta Vidit
Published: October 2019

Background: To study and analyse the factors affecting the proportion of retinopathy of prematurity (ROP) distribution between the urban and semi-urban regions in North India.
Methods: Retrospective, observational, cross-sectional study. All babies referred for ROP examination by paediatricians or other general ophthalmologists between 2013 – 2016 were included in the study. Demographic, clinical and treatment related findings were recorded.
Results: Five hundred and fifty-eight (467: urban & 91: semi urban) babies were examined for ROP. The mean birth weight in the urban and semi-urban setting was 1348.6 ± 395.21 gm and 1703.77 ± 401.76 gm respectively. The mean gestational age was 30.99 ± 2.93 weeks and 30.73 ± 2.08 weeks in the urban and semi-urban cohorts respectively. The average time for first ophthalmic examination following birth was 23.82 ± 13.69 (range: 3-77) days in the urban and 101.16 ± 238.26 (range: 13- 330) days in the semi-urban setting. 94% of the babies completed all screening examination visits. Any ROP was identified in 11.6% and 33.0% of the urban and semi-urban cohorts respectively; Type 1 was detected in 7.5% of urban babies and 23.1% of semi-urban babies
Conclusion: Differences in the proportion of babies developing any ROP and Type 1 ROP between the semi-urban and urban groups is likely due to selection bias, as a high proportion of semi-urban babies did not attend for examination or failed to complete all the examinations necessary. This was particularly true for females. More needs to be done to increase access to regular, systematic screening of preterm babies within neonatal units.
Pretreatment Neutrophil-to-Lymphocyte Ratio Predicts Prognosis in Patients with Diabetic Macular Edema Treated with Ranibizumab
Authors: Hu Yuxiang , Cheng Yi , Xu Xiaoxuan , Yang Bo , Mei Feng , Zhou Qiong , Yan Li , Wang Jun , Wu Xiaorong
Published: October 2019

Background: To investigate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in patients with diabetic macular edema (DME) treated monthly with ranibizumab.

Methods: We retrospectively analyzed the medical records of all patients who received intravitreal ranibizumab (IVR) treatment for DME at the First Affiliated Hospital of Nanchang University between December 2015 and December 2017. Clinicopathological parameters, including NLR, were evaluated to identify predictors of better outcomes of IVR monotherapy.

Results: Ninety-one treatment-naïve eyes treated with IVR for DME were retrospectively analyzed in this study. Baseline best-corrected visual acuity (BCVA), neutrophils, NLR, monocyte-to-lymphocyte ratio, and platelet-to-lymphocyte ratio were negatively correlated with the changes in BCVA at 24 weeks compared with the baseline, while baseline central retinal thickness and lymphocytes were positively correlated with the changes in BCVA at 24 weeks compared with the baseline. Multiple linear regression analysis revealed that NLR was independently associated with the mean change of BCVA between baseline and week 24. In addition, patients with NLR < 2.27 showed a better improvement in letter score than those with NLR > 2.27.

Conclusion: Pretreatment NLR is independently associated with the BCVA in DME patients treated with IVR, and higher pretreatment NLR may contribute to inferior BCVA outcomes.
HLA-B*5701 Allele Prevalence in Treatment-Naïve HIV-Infected Patients from Colombia
Authors: Martínez-Buitrago Ernesto , Oñate José Millán , García-Goez José Fernando , Álvarez Jorge , Lenis William , Sañudo Luz Marina , Rubiano Luisa Consuelo
Published: October 2019

IBackground: The HLA-B*57:01 allele is associated with a hypersensitivity reaction to abacavir. Due to the lack of knowledge of HLA-B*57:01 prevalence in Colombia, routine screening is not performed and is not recommended by the national guidelines. We aimed to determine the prevalence of HLA-B*57:01 in HIV population from Colombia. Methods: This cross-sectional study included naïve HIV-infected adults from 13 cities of the country. The presence of HLA-B*57:01 was determined by using SSP-PCR in blood samples. Prevalence rates were stratified by sex, race, and region of origin. Results: HLA-B*57:01 allele prevalence in Colombian HIV-infected individuals was 2.7%. When stratifying for the race, the prevalence was 4% for whites, 2.6% for other race (mainly mestizo), and 1.9% for Afro-Colombians. The prevalence varied from 0% up to 11.4% depending on the department of origin. The highest prevalence rates were found in Caldas (11.4%), Antioquia (5%), Risaralda (4.8%), and Valle del Cauca (4.3%). When distributed by country zones, the central, with a racial predominance of Caucasians and mestizos, was the highest (6.0%, 0R=4.1, CI 1.2 – 12.8, p=0,016). Conclusions: The overall prevalence of HLA-B*57:01 in Colombia was lower than the reported rates for other Latin American countries such as Brazil, Costa Rica, and Argentina, but similar in comparison to Chile and Mexico. The diversity in the racial and ethnic heritage shown in our data supports the recommendation to implement routine screening for the HLA-B*57:01 allele before initiation of abacavir-containing antiretroviral therapy in the Colombian HIV management guidelines.
Mechanisms of Gene Rearrangement in 13 Bothids Based on Comparison with a Newly Completed Mitogenome of the Threespot Flounder, Grammatobothus polyophthalmus (Pleuronectiformes: Bothidae)
Authors: Luo Hairong , Kong Xiaoyu , Chen Shixi , Shi Wei
Published: October 2019

Background: The previously characterized mitogenomes of 12 teleost fish of the bothid family (order Pleuronectiformes) indicated that the genomic-scale rearrangements occurred in this teleost lineage. A novel mechanism of genomic rearrangement called the Dimer-Mitogenome and Non-Random Loss (DMNL) model was used to account for the rearrangement found in one of these bothids, Crossorhombus azureus. Results: The 18170 bp mitogenome of G. polyophthalmus contains 37 genes, two control regions (CRs), and the origin of replication of the L-strand (OL). This mitogenome is characterized by genomic-scale rearrangements: genes located on the L-strand are grouped in an 8-gene cluster (Q-A-C-Y-S1-ND6-E-P) that does not include tRNA-N; genes found on the H-strand are grouped together (F-12S … CytB-T) except for tRNA-D that was translocated inside the 8-gene L-strand cluster. Compared to non-rearranged mitogenomes of teleost fishes, gene organization in the mitogenome of G. polyophthalmus and in that of the other 12 bothids characterized thus far is very similar. These rearrangements could be sorted into four types (Type I, II, III and IV), differing in the particular combination of the CR, tRNA-D gene and 8-gene cluster and the shuffling of tRNA-V. The DMNL model was used to account for all but one gene rearrangement found in all 13 bothid mitogenomes. Translocation of tRNA-D most likely occurred after the DMNL process in 10 bothid mitogenomes and could have occurred either before or after DMNL in the three other species. During the DMNL process, the tRNA-N gene was retained rather than the expected tRNA-N′ gene. tRNA-N appears to assist in or act as OL function when the OL secondary structure could not be formed from intergenic sequences. A striking finding was that each of the non-transcribed genes has degenerated to a shorter intergenic spacer during the DMNL process. These findings highlight a rare phenomenon in teleost fish. Conclusions: This result provides significant evidence to support the existence of dynamic dimeric mitogenomes and the DMNL model as the mechanism of gene rearrangement in bothid mitogenomes, which not only promotes the understanding of mitogenome structural diversity, but also sheds light on mechanisms of mitochondrial genome rearrangement and replication.
Kinetic and equilibrium studies on the adsorption of Direct Red 23 dye from aqueous solution using montmorillonite nanoclay
Authors: Mahvi Amir Hossein , Dalvand Arash
Published: October 2019

In this research, the adsorption of the Direct Red 23 dye from synthetic textile wastewater using nanoclay was studied in a batch system. The properties of nanoclay were investigated by scanning electron microscope, Fourier transform infrared, and EDX analysis. The specific surface area of the nanoclay was determined using Sear's method. The results revealed that with increasing adsorbent dose and contact time and decreasing pH, ionic strength, and adsorbate concentration, dye removal efficiency has increased. Nanoclay could remove 99.4% dye from the solution containing 50 mg/L dye at 30 min. The results indicated that dye removal followed pseudo-second-order kinetic (R2 > 0.99) and the Langmuir isotherm. According to the findings, nanoclay is an effective adsorbent for direct dye removal from wastewater.
Water quality monitoring: from conventional to emerging technologies
Authors: Ahmed Umair , Mumtaz Rafia , Anwar Hirra , Mumtaz Sadaf , Qamar Ali Mustafa
Published: October 2019

The rapid urbanization and industrial development have resulted in water contamination and water quality deterioration at an alarming rate, deeming its quick, inexpensive and accurate detection imperative. Conventional methods to measure water quality are lengthy, expensive and inefficient, including the manual analysis process carried out in a laboratory. The research work in this paper focuses on the problem from various perspectives, including the traditional methods of determining water quality to gain insight into the problem and the analysis of state-of-the-art technologies, including Internet of Things (IoT) and machine learning techniques to address water quality. After analyzing the currently available solutions, this paper proposes an IoT-based low-cost system employing machine learning techniques to monitor water quality in real time, analyze water quality trends and detect anomalous events such as intentional contamination of water.
O Papel do Entendimento na Aceitação de Teorias Científicas
Authors: Brito Breno Pascal de Lacerda
Published: October 2019

O critério de aceitação de uma teoria científica deve ser pautado no Entendimento da mesma. Isso porque a concepção de aceitação de teorias científicas com base na expressão dos valores epistêmicos não é possível, dado o problema da incomensurabilidade. Para resolver essa questão devemos considerar as competências de um agente epistêmico e como as mesmas sustentam sua aceitação. Ao analisar o processos de escolha de teorias científica, se pode concluir que o mesmo não está associado a mera formação de crenças em sua adequação empírica. Sendo um processo não vinculado com a verdade, e sim associado com a melhor explicação, consequentemente gerando melhor Entendimento, o qual é, logicamente e conceitualmente, quesito necessário para Aceitação de dado estado cognitivo consequente de uma Explicação. Como o Entendimento é uma característica de um agente virtuoso, podemos crer que a teoria escolhida seria resultado da habilidade de um agente virtuoso, e consequentemente uma teoria confiável.
Correlation of Warm and Cold Ischemic Time to Graft Function in Kidney Transplant: A Single Centre Report
Authors: Nugroho Eriawan A. , Hidayat Arif , Hidayat Ahsanu T.
Published: October 2019

Background:

Kidney transplantation has been known as a major advancement of modern medicine which provides high-quality life years to patients with irreversible kidney failure (end-stage renal disease, ESRD) worldwide. The first kidney transplantation in Semarang was carried out at Telogorejo Hospital in 1985. Dr. Kariadi Hospital, has also undertaken kidney transplantation 28 times since January 2014 until September 2018. Kidney ischemic time is one of the most important factors which can affect the outcome of kidney transplantation. Prolonged ischemia of the graft can be related to transplantation’s effects. This study aimed to evaluate the influence of warm and cold ischemic time on the outcome of kidney transplantation in Dr. Kariadi Hospital Semarang.

Material and Methods:

This is an observational, cross-sectional study. The data was collected from medical record of all patients who underwent kidney transplantation from January 2014 until December 2018 and the level of creatinine and urine production before and after transplantation was documented. A total of 28 patients were registered and completed the inclusion criteria. The results of the study were tabulated and statistical analysis was performed using SPSS 23.0. The relationship was declared meaningful if p = 0.05 was obtained.

Result:

From the analysis of the research that has been done using the Pearson correlation test and hypothesis test Wilcoxon, it was found that there was a relationship between ischemic time and a decrease in creatinine level from r = -0.4489 with a value of p = 0.008. From the analysis of the research, a relationship between ischemic time and urine production was found after transplantation with a value of r = -0.562 and a value of p = 0.002.

Conclusion:

The results of this study show a strong correlation between the length of total ischemic time with a decrease in creatinine and urine production which means that the longer ischemic time, the lower the decrease in creatinine levels and the lesser the urine production.
Advances in Strain Engineering for Improved Bio-fuel Production- a Perspective
Authors: Ratnaparkhe Supriya , Ratnaparkhe Milind B.
Published: October 2019

Bio-fuels are ecologically sustainable alternates of fossil fuel and have attracted interest of research
community in the last few decades. Microorganisms such as bacteria, fungi and microalgae have important
roles to play at various steps of bio-fuel production. And therefore several efforts such as genetic engineering
have been made to improve the performance of these microbes to achieve the desired results. Metabolic engineering
of organisms has benefitted immensely from the novel tools and technologies that have recently been
developed. Microorganisms have the advantage of smaller and less complex genome and hence are best suitable
for genetic manipulations. In this perspective, we briefly review a few interesting studies which represent
some recent advances in the field of metabolic engineering of microbes.
On the electoral punishment/rewarding of the incumbent Can voters do it?
Authors: Caleiro António Bento
Published: October 2019

The article analyzes the possibility of voters penalizing or rewarding the incumbent (economic) performance at the polls. For this, it is considered that voters have limited rationality. This does not prevent them from performing this task without bias, which should serve as an obligation to use the elections to eectively penalize or reward the incumbent and/or not elect those who do not deserve it.
Resumo

O artigo analisa a possibilidade de os eleitores penalizarem, ou recompensarem, nas urnas, o desempenho (económico) do governo. Para tal, considera-se que os eleitores dispõem de racionalidade limitada. Tal não os impede de desempenharem aquela tarefa sem enviesamento, o que deveria servir de obrigação de utilização das eleições para, efectivamente, penalizar, ou recompensar, o governo e/ou não elegerem quem não o merece.
Functional condition of the thyroid gland of newborns from methers with a diffuse toxic goiter
Authors: Vorokhobina N. V. , Lovkova Y. S. , Kuznetsova A. V. , Kovalyova Yu. V. , Baranov V. L.
Published: October 2019

Objective: to study the functional state of the thyroid gland in newborns from mothers with diffuse toxic goiter, depending on the level of antibodies to thyroid stimulating hormone receptors (AB-rTSH).

Materials and methods: 68 newborns from 67 mothers with diffuse toxic goiter were examined. The control group included 49 newborns from 49 mothers without thyroid pathology. To assess the functional state of the thyroid gland of newborns, we determined the levels of thyroid stimulating hormone, free thyroxine (fT4), and AB-rTSH in cord blood and calculated the TSH/fT4 coefficient, which allows us to differentiate congenital hypothyroidism from neonatal thyrotoxicosis. On the 4-7th day of life, all newborns underwent ultrasound examination (ultrasound) of the thyroid gland.

Results: newborns from mothers with diffuse toxic goiter had lower growth-weight indices in comparison with the same indices of the control group and they often showed thyroid hyperplasia. It was shown that the increased content of AB-rTSH in the blood serum of pregnant women with diffuse toxic goiter and in the umbilical cord blood of newborns can contribute to the development of neonatal thyrotoxicosis, detected in 16.2 % of newborns.

Conclusions: increased levels of AB-rTSH in the blood serum of mothers with DTG, especially in the second half of pregnancy, and in the umbilical cord blood of newborns affect the formation of thyroid hyperplasia in newborns and contribute to the development of neonatal thyrotoxicosis.
The experience of a comprehensive assessment of the effectiveness of antihypertensive therapy in clinical practice
Authors: Solgalova S. A. , Glukhova T. V. , Znamenskaya I. A. , Romanova I. B.
Published: October 2019

Objective:to study the antihypertensive efficacy of a new dosage form of perindopril A — tablets dispersed in the oral cavity — in the group of patients with arterial hypertension (AH) on an outpatient basis.

Material and methods:the study included 30 patients (mean age 53.8 ± 0.9 years) with the presence of arterial hypertension, diagnosed initially, or with no control of blood pressure at the background of previous antihypertensive therapy. All investigators were administered perindopril A in the form of a dispersible form in a dose of 10 mg in monotherapy or in combination with indapamide – in case of failure to achieve target blood pressure after 2 weeks of observation. The total duration of the study is 3 months.

Results:by the end of the observation, the SBP / DBP decreased by 35.6 ± 2.3 / 16.5 ± 1.0 mm Hg. Correction of therapy with the addition of indapamide-retard was required in 6 (20%) patients. Effective antihypertensive therapy was accompanied by a significant decrease in daily (according to ICBP data), intravisit, and visit-to-visit variability of the SBP, which was 4.4 mm Hg in terms of standard deviation by the end of the observation. The use of a new dosage form of perindopril A was accompanied by a significant increase in adherence to therapy.

Conclusion:the use of a new dosage form of perindopril A — tablets dispersed in the oral cavity — in monotherapy or in combination with indapamide-retard can improve the treatment of patients with hypertension who do not have target BP values.
Paraneoplastic neuromuscular syndromes at the outpatient level
Authors: Chertousova A. E. , Chernikova I. V.
Published: October 2019

Objective: to develop tactics for the differential diagnosis of paraneoplastic neuromuscular syndromes in patients at the outpatient level.

Materials and methods: the study included 50 patients with classical neuromuscular paraneoplastic syndromes (experimental group) and 50 patients with neuromuscular syndromes of non-paraneoplastic nature (control group). All patients underwent a comprehensive laboratory and instrumental examination at the Regional Consultative and Diagnostic Center of the Ministry of Health of the Rostov Region from 2014 to 2018.

Results: the evaluation of clinical differences in patients of the experimental and control groups was created. When comparing the laboratory parameters, it was revealed that the SFMC, D-dimer, CRP-2 levels significantly increased in patients with paraneoplastic lesions (p <0.05). In the experimental group, a significant increase in the amplitude of the M-response from the sensory nerves (> 5.25 mV) was noted. Based on obtained data, differential diagnosis algorithms for patients with studied neuromuscular lesions at the outpatient level have been developed.

Conclusions: the conducted study allows the implementation of non-serological diagnostics algorithms for classical neuromuscular paraneoplastic syndromes in outpatient practice.
Determinant Factors of Public Acceptance of Stress Management Apps: Survey Study
Authors: Apolinário-Hagen Jennifer , Hennemann Severin , Fritsche Lara , Drüge Marie , Breil Bernhard
Published: October 2019

Background

Chronic stress is a major public health concern. Mobile health (mHealth) apps can help promote coping skills in daily life and prevent stress-related issues. However, little is known about the determinant factors of public acceptance of stress management in relation to preferences for psychological services.

Objective

The aim of this survey study was to (1) assess determinant factors of public acceptance (behavioral use intention) of stress management apps based on an adapted and extended version of the Unified Theory of Acceptance and Use of Technology (UTAUT) model and (2) explore preferences for mHealth apps compared with other mental health services.

Methods

Using convenience sampling, participants completed a multiscale 54-item Web-based survey. Based on significant correlations with acceptance, hierarchical stepwise regression analysis was performed within three blocks: (1) background and stress-related control variables, (2) beliefs and attitudes toward using mHealth, and (3) the core UTAUT determinants. The preference for mHealth apps in comparison with nine other mental health services (operationalized as readiness to use) was analyzed using paired t tests.

Results

Of 141 participants, nearly half (69/141, 48.9%) indicated prior mHealth use. Acceptance of stress coping apps was moderate (mean 3.10, SD 1.03, range 1-5). Hierarchical stepwise regression including four of 11 variables (R2=.62; P=.01, f2=1.63) identified positive attitudes toward using mHealth for stress coping (beta=0.69, P<.001, 46% R2 increase above block 1, f2=0.85), skepticism/perceived risks (beta=−0.14, P=.01, f2=0.16), and stress symptoms (beta=0.12, P=.03, f2=0.14) as significant predictors of acceptance. UTAUT determinants added no predictive contribution beyond attitudes (all P>.05, R2 increase of 1%), whereas post hoc analysis showed significant R2 increases of attitudes and skepticism/perceived risks beyond UTAUT determinants (all P<.001, R2 increase of 13%). The readiness to use apps was equivalent to or significantly higher than most service types, but lower than information websites.

Conclusions

Attitudes may be at least as predictive for the acceptance of stress management apps as for more elaborated outcome beliefs. Efforts aimed at improving the public adoption of mHealth could put more emphasis on the pleasant aspects of app use, address misconceptions, offer stress screening tools on health websites, and increase options to try high-quality apps.
Toward a Taxonomy for Analyzing the Heart Rate as a Physiological Indicator of Posttraumatic Stress Disorder: Systematic Review and Development of a Framework (Preprint)
Authors: Sadeghi Mahnoosh , Sasangohar Farzan , McDonald Anthony D
Published: October 2019

BACKGROUND

Posttraumatic stress disorder (PTSD) is a prevalent psychiatric condition that is associated with symptoms such as hyperarousal and overreactions. Treatments for PTSD are limited to medications and in-session therapies. Assessing the way the heart responds to PTSD has shown promise in detecting and understanding the onset of symptoms.

OBJECTIVE

This study aimed to extract statistical and mathematical approaches that researchers can use to analyze heart rate (HR) data to understand PTSD.

METHODS

A scoping literature review was conducted to extract HR models. A total of 5 databases including Medical Literature Analysis and Retrieval System Online (Medline) OVID, Medline EBSCO, Cumulative Index to Nursing and Allied Health Literature (CINAHL) EBSCO, Excerpta Medica Database (Embase) Ovid, and Google Scholar were searched. Non–English language studies, as well as studies that did not analyze human data, were excluded. A total of 54 studies that met the inclusion criteria were included in this review.

RESULTS

We identified 4 categories of models: descriptive time-independent output, descriptive and time-dependent output, predictive and time-independent output, and predictive and time-dependent output. Descriptive and time-independent output models include analysis of variance and first-order exponential; the descriptive time-dependent output model includes a classical time series analysis and mixed regression. Predictive time-independent output models include machine learning methods and analysis of the HR-based fluctuation-dissipation method. Finally, predictive time-dependent output models include the time-variant method and nonlinear dynamic modeling.

CONCLUSIONS

All of the identified modeling categories have relevance in PTSD, although the modeling selection is dependent on the specific goals of the study. Descriptive models are well-founded for the inference of PTSD. However, there is a need for additional studies in this area that explore a broader set of predictive models and other factors (eg, activity level) that have not been analyzed with descriptive models.

CLINICALTRIAL
Wooden Temple Construction in the Russian North of the Late 18th — Early 20th Century
Authors: Ходаковский Евгений , Hodakovskiy Evgeniy , Бодэ Андрей , Bode Andrey , Зинина Ольга , Zinina Ol'ga , Носкова Арина , Noskova Arina
Published: October 2019

The paper explores the basic fundamental and applied objectives associated with the study of the wooden church architecture of the Russian North of the last centuries (late 18th — early 20th) — a period understudied in the domestic science. The authors provide sources for the research; specific examples show the features of the ongoing archival and field studies of the wooden monuments in Onega and Kargopol districts of Arkhangelsk region, identify the core theoretical areas of research focused on the wooden temple construction in the Russian North of the late period.
Comparison and Classification of World Economies by E-Commerce Level
Authors: Архипова Марина , Arhipova Marina , Ямбуренко Елена , Yamburenko Elena
Published: October 2019

The fast-paced digitalization of the global economy takes place along the growing importance and share of e commerce in the global trade. International organizations and governments consider e commerce a potential driver of economic growth and improvements in the national welfare, as well as a smart tool for overall catch-up effect. However, there is little agreement among the todays’ academic and political communities about any factors that are key to the development of digital commerce and better ways helping to tackle political and regulatory issues that affect it.
Researchers aim at comparing and classifying national economies by the level of e commerce with due regard to the main aspects of their functioning, as well as testing the hypothesis that the level of digital commerce varies significantly by the world economies driven by diffe­rent key factors in the formation of the digital economy. The research methods are goal-dependent and relate to benchmarking performed using multidimensional classification of objects under study, in particular, using agglomerative hierarchical algorithms. Interpreting outcomes involves the logical-intuitive method of generalizing and concluding.
The findings of this study are of interest to international and national governmental and non-governmental organizations driving the global, regional and/or national economies, and can serve as a springboard for further research using the insights obtained in the course of this project.
MODELS OF POLITICAL BEHAVIOR OF YOUTH MIDDLE CLASS OF MODERN AGGLOMERATIONS: ON THE EXAMPLE OF THE MAIN REGIONS OF THE NORTH]WEST AND SOUTH SIBERIA
Authors: Lagutin Oleg V , Negrov Eugene O
Published: October 2019

The article deals with the peculiarities of the models of political behavior of young people, which can be attributed to the middle class. The relevance of the study is in the combination of a well-founded review of the main directions of research of the role of youth participation in the social and political process and the involvement of a specific empirical study conducted in the autumn of 2018, which allows to highlight various aspects of the situation. The empirical part of the study is based on the study “Ideas of Youth about Possibilities of Youth Leaders and Youth Organizations in Russia”, which was conducted in late September and early October 2018 in four regions of the Russian Federation: Altai, Leningrad and Novosibirsk Regions and St. Petersburg. The method of research was a personal standardized interview, the sample size was 1000 respondents (250 in each of the regions), who were representatives of young people aged 14 to 30 that permanently reside in the territory of the studied subjects of the federation. Based on factor and cluster analyzes, the research presents the main models of the political behavior of young people belonging to the middle class. The article is of interest to researchers of interconnections between the real political process and youth as a significant group of the population.
THE MAIN FEATURES OF APPLICATION OF POLITICAL TECHNOLOGIES IN THE RUSSIAN INTERNET SPACE
Authors: Emelianov Anton I
Published: October 2019

The article discusses the impact of Internet technologies on the political process in Russia and in the world. The author draws attention to the emergence of new trends in the field of IT, which bring new to the electoral process, PR-activities, agitation, propaganda and counter-propaganda. It is suggested that political actors should act within the framework of the new rules of the game, without neglecting the transfer of political struggle in the Internet space. The article draws attention to the fact that the Internet activity of political actors can be both positive and negative in perception and goals. Given the impact that the Internet has on the political sphere of society, we can assume that the virtual environment will be the main stage of political struggle. The author emphasizes that modern political technologists should take this factor into account in their activities. Thus, the author concludes that the online space significantly expands the tools of political campaigns and radically transforms the relationship between citizens and the state, forming the real prerequisites for the development of democracy.
THE IMPACT OF MIGRATION FROM VENEZUELA ON THE DOMESTIC POLITICAL SITUATION IN THE UNITED STATES
Authors: Belokonev Sergey Yu , Vodopetov Sergey A , Ivanov Vladimir G
Published: October 2019

The authors analyze the impact of migration from Venezuela on the domestic policy of the United States. According to the data for 2017, more than 11 percent of immigrants to the United States from South America are Venezuelans, and the same figure for 2016 was close to 9 percent, which indicates a fairly sharp increase in the number of refugees. An active influx of Venezuelans may be one of the key factors in the future US 2020 presidential elections. The largest diaspora of Venezuelans in the United States lives in Florida, which will be one of the key states in the future presidential election campaign. In connection with the potential loss of Republican’s positions in such an important region as Florida, it is necessary for the administration of Donald Trump to reconsider its policy in the state. In addition, representatives of the Democratic party are greatly interested in increasing influence in the state. Thus, the authors conclude that the administration of Donald Trump generally benefits from the crisis in Venezuela, as it will help to carry out a number of domestic political reforms aimed at economic protectionism and tackling of immigration.
RESILIENCE CONCEPT AS A METHODOLOGICAL BASIS OF A NEW APPROACH TO COUNTERING INTERNATIONAL TERRORISM
Authors: Tulupov Dmitriy S , Kotsur Gleb V
Published: October 2019

The aim of this article is to identify actual and prospective opportunities for the use of “resilience” concept in counter-terrorism warfare. The resilience is usually defined as an ability of an individual, society or ecosystem to recover or adapt after a shock. Discourse-analysis of the local periodical press enabled authors to draw two important conclusions. Firstly, resilience as a strength feature of a (city) community is internally generated, rather than imposed from top down. Secondly, the resilience of urban population to terrorism both in Russia and in European countries has similar features, namely the high degree of low-level civil self-organization and active use of social networks potential. The relevance of resilience serves as an indicator that this concept has become a core element of a new public security paradigm in the West. At the same time, resilience is not featuring in the Russian social-political discourse at all. However, authors have identified a number of provisions in the 2009 Concept of combating against terrorism, which might be considered as feasible prerequisites for the articulation of resilience in the Russian discourse in the future. Filling this gap might be a strategically important task in context of enhancement of the Russian Federation’s strategy of counter-terrorism activity.
formação de clusters criativos e a coexistência nas cidades contemporâneas
Authors: Falcão Christianne Soares , Barros Alberico Paes Barreto , Leão Gabriela Viana
Published: October 2019

Uma cidade criativa é regida, entre outras coisas, por conexões e, por isso, a coexistência se torna um fator relevante para seu publicness. O artigo ora apresentado tem como objetivo lançar um olhar para as mudanças sociais e econômicas ocorridas na sociedade contemporânea que fizeram com que se deslocasse o foco das atividades industriais para as atividades intensivas em conhecimento. Dessa forma, procura compreender o contexto de formação de uma nova economia cuja cadeia produtiva se estabelece sobre criatividade e inovação. Essa nova economia, no qual o capital tem base intelectual, fundamenta-se no indivíduo, na formação de redes sociais e na troca de conhecimentos, levando ao surgimento de uma estrutura econômica baseada na concentração geográfica de empresas inter-relacionadas com foco em produtos culturais e criativos, que estabelecem a coexistência no ambiente urbano onde se instalam e a consequente transformação das cidades: os Clusters Criativos.
rap na cidade:
Authors: Mendes Gabriel Gutierrez , Neiva Gabriel Chavarry
Published: October 2019

O propósito do artigo é mobilizar o conceito de “quinto elemento” da cultura Hip Hop, entendido como arma em potencial contra confinamentos cognitivos e relevante gatilho estético de resistência no ambiente urbano, para investigar a intervenção das Rodas de Rap do Circuito Carioca de Ritmo e Poesia (CCRP) na cidade do Rio de Janeiro. O artigo atesta a dimensão comunitária do rap nas Rodas, definindo-a como resultado da “criatividade social” das "neotribos" que giram no entorno do Hip Hop carioca. Inspirado pela noção de “quinto elemento”, o rap é se apresenta como uma linguagem capaz de produzir um élan comunitário na vida da cidade, a partir de sua música. Assim como em sua origem em NY, quando jovens do sul do Bronx redefiniram suas identidades culturais num espaço urbano violento e empobrecido, o rap, através das Rodas no Rio de Janeiro, segue emergindo com energia e vitalidade para intervir na dinâmica da cidade.
cobertura de cidades devastadas em testemunhos paralisantes e interpretativos de correspondentes internacionais no projeto Memória Globo
Authors: Farias Almeida Simão
Published: October 2019

As representações da cidade no discurso midiático fogem dos sentidos funcionalistas e racionalistas, legitimando a fragmentação das experiências de sujeitos no construto de narrativas sobre os lugares a partir dos quais falam (MARTÍN-BARBERO, 2004, p.277). Seguindo o método de pragmática do discurso jornalístico (RODRIGUES, 2011, p.20), defenderemos que os relatos dos correspondentes internacionais são ininterruptos, não hierárquicos podendo aparecer fora das produções jornalísticas e combinatórios de perspectivas políticas, econômicas, sociais e ambientais. Neste sentido, analisaremos testemunhos de repórteres no projeto Memória Globo (2018) a respeito de coberturas de catástrofes ambientais, demonstrando que o jornalismo interpretativo contraria a mera apresentação de consequências dos fatos e permite o apontamento de soluções à comunidade nacional de origem dos correspondentes, necessárias ao restabelecimento de cidades devastadas.
Hayao Miyazaki:
Authors: E Silva Raphael Parreira , Mendes Conrado Moreira
Published: October 2019

Com o intuito de depreender o estilo autoral do japonês Hayao Miyazaki, são analisados, neste trabalho, seus seguintes filmes: Porco Rosso (1992), A Viagem de Chihiro (2001) e Vidas ao Vento (2013). Tais obras são examinadas à luz do conceito de estilo, conforme propõe Discini (2014), articulando-se tal concepção à teoria do autor de Stam (2003), além de debater os alicerces em torno da caracterização de personagens centrais de acordo com Brait (2005) e Brecht (2002). Por meio das análises realizadas, pôde-se concluir que o estilo autoral de Miyazaki se constrói a partir de recorrências observadas tanto no plano do conteúdo, quanto no plano da expressão.