bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of chronic disease in older adults in multitier eye-care facilities in South India: Electronic medical records-driven big data analytics report
Authors: Behera Umesh Chandra , Salzman Brooke , Das Anthony Vipin , Prashanthi Gumpili Sai , Lalakia Parth , Derman Richard , Panigrahy Bharat
Published: November 2021

Purpose:

To study the prevalence of systemic conditions in older adults, either self-reported or discovered during routine eye examinations, at multitier eye-care facilities over the past decade, and to explore their association with vision and common ocular disorders, including cataract, glaucoma, and retinopathy.

Methods:

Retrospective review of a large data set compiled from the electronic medical records of patients older than 60 years who presented to an eye facility of a multitier ophthalmology network located in 200 different geographical locations that included urban and rural eye-care centers spread across four states in India over a 10-year period.

Results:

618,096 subjects aged 60 or older were identified as visiting an eye facility over the 10-year study period. The mean age of the study individuals was 67·28 (±6·14) years. A majority of older adults (66·96%) reported being free of systemic illnesses. Patients from lower socioeconomic status had a lower prevalence of chronic systemic disease, but the presenting vision was poorer. Hypertension (21·62%) and diabetes (18·77%) were the most commonly reported chronic conditions in patients who had concomitant systemic illness with visual concerns.

Conclusion:

The prevalence of chronic systemic illnesses in older adults presenting to multitier eye-care facilities is relatively low, except in those with diabetic retinopathy. These observations suggest a need to include active screening for common chronic diseases in standalone eye-care facilities to achieve a more accurate assessment of chronic disease burden in the older population.
Outcome of large angle exotropia treated by single stage adjustable strabismus surgery with monitored conscious anesthesia
Authors: Asafali Fasna , Rajamani Muralidhar , Periannan Chidambaram , Michael Sekar , Dandapani Ramamurthy
Published: November 2021

Purpose:

To evaluate the outcomes of large-angle exotropia by single-stage adjustable strabismus surgery (SSASS) under monitored conscious anesthesia.

Methods:

A prospective study was done in 33 patients above 14 years with ≥40 prism diopters (PD) of exotropia. All patients underwent SSASS under monitored conscious anesthesia (topical anesthesia plus intravenous sedation). For deviations of ≤55 PD, two horizontal rectus muscles, and for >55 PD, three rectus muscles were operated and a decision on adjustment/operating on an additional rectus muscle was taken after assessing the alignment. Monitored conscious anesthesia allowed us to check our results after surgery and plan further surgery/adjustment to achieve the desired alignment.

Results:

Mean preoperative deviation for distance was 52 ± 11.1 PD. The target alignment was achieved with the initial surgical plan in 10/21 patients with <55 PD exotropia and 4/12 patients with >55 PD exotropia, and one patient in each group needed adjustment. The remaining patients needed additional rectus muscle surgery. One patient with >55 PD exotropia needed both adjustment and additional rectus surgery. The success rate for distance correction was 85% at 6 months and 1 year. The overall success rate was 71% at 6 months. Percentage of patients with binocular single vision improved from 31% preoperatively to 78% by 6 months. Incidence of oculocardiac reflex was 6.1%.

Conclusion:

SSASS under monitored conscious anesthesia is a viable option for large-angle strabismus correction with good patient comfort and safety.
Role of Maternal Nutritional Supplementation on the Hormonal Profile and Immunohistochemical Analysis of Testicular Development of Fetal Rats
Authors: Kusemiju Taiwo O. , Afolayan Olasunmbo O. , Ogunlade Babatunde
Published: November 2021

Introduction:

This study elucidated the role of maternal microelement supplementation on fetal testicular development.

Materials and Methods:

Twenty-eight Wistar rats (21 females and 7 males) were randomly divided into seven groups comprising three females to one male: Group A – standard feed and water; Group B – diet deficient in all the micronutrients (Fe, Cu, Se) and water; Group C – diet fortified with 0.2 mg/kg of selenium and water; Group D – diet enriched with 40 mg/kg of iron and water; Group E – diet fortified with 8 mg/kg of copper and water; and Group F – diet enriched with all nutrients and water. All administration was via oral gavage; thereafter, animals were sacrificed at day 20 of pregnancy. Placenta measurements, testes, and blood serum were obtained for analysis.

Results:

The results showed statically a significant decrease (p<0.05) in placental and fetal weight (WPF), the distance between fetus and mother (DFM), the concentration of trace elements; FSH and LH levels among chaff only group when compared to the Control group. Testicular histomorphology and immunohistochemical studies of the animals in the chaff alone diet showed mild fetal Leydig cells in the interstitium, primitive germ cells in the testicular cord, pre-Sertoli cell necrosis, and decreased positive expression compared with the control.

Conclusion:

Administration of single and combined doses of nutritional supplements diet significantly preserved the fetal parameters, hormone profile, and histochemical analysis of the testis.
Aqueous Extract of Nicotiana tabacum Impaired Serum Testosterone and Testicular Weight in Male Wistar Rats
Authors: Nwaji Azubuike Raphael , Ante Iniobong Ating , Nwoke Favour-Ann Kyrian
Published: November 2021

Background:

Tobacco which is a product of Nicotiana tabacum (N. tabacum) has nicotine as its primary phytochemical. Nicotine has been reported to be an addictive drug and the leading cause of tobacco addiction worldwide. The male reproductive system is known to be highly sensitive to many chemicals and drugs which have been found to pose adverse effects on male reproductive capacity.

Aim:

The aim of this study is to investigate the effect of the aqueous extract of N. tabacum on serum testosterone and testicular weight in male Wistar rats.

Materials and Methods:

A total of 18 male rats weighing (140–230 g) were used for this study. The animals were randomly divided into three groups (A, B, and C), containing six rats each. Group A served as control, whereas Group B and C were orally administered sublethal doses of 20 and 30 mg/kg body weight of the N. tabacum extract, respectively, once per day for 21 days. At the end of the experimental period, all the animals were sacrificed. Blood samples were collected for hormonal assay and both testes were excised and weighed immediately.

Results:

There was a significant decrease (P < 0.05) in the serum testosterone levels of rats treated with the extract in a dose-dependent manner when compared with the control, there was also a significant reduction in the testicular weight of the treated groups when compared to the control group (P < 0.05).

Conclusion:

The results suggest that aqueous extract of N. tabacum at doses of 20 mg/kg and 30 mg/kg when administered for a period of 3-week impaired serum testosterone level, testicular weight, and bodyweight of male Wistar rats.
Oncological Outcomes of High-Risk Prostate Cancer Patients between Robot-Assisted Laparoscopic Radical Prostatectomy and Laparoscopic Radical Prostatectomy in Taiwan
Authors: Liao Chieh-Chun , Lu Yu-Chuan , Tai Huai-Chin , Chen Chung-Hsin , Pu Yeong-Shiau , Huang Chao-Yuan
Published: November 2021

Objective:

To compare pathological and oncological outcomes between robotic-assisted laparoscopic radical prostatectomy (RaLRP) and laparoscopic radical prostatectomy (LRP) among high-risk prostate cancer patient in a tertiary center in Taiwan.

Materials and methods:

From November 2003 to October 2013, 129 high-risk prostate cancer patients receiving minimally-invasive radical prostatectomy were included. The Kaplan–Meier analysis was used for measuring biochemical recurrence-free survival (BFS). Multivariate logistic regression models and Cox proportional hazards regression models were used to determine predictors of positive surgical margin and BFS.

Results:

Among the 129 high-risk prostate cancer patients included, 80 (62%) patients received LRP and 49 (38%) patients received RaLRP. There was no significant difference of positive surgical margin and biochemical recurrence rate between RaLRP and LRP group (P = 0.802 and 0.292). Higher pathological T stage predicted an increased likelihood of positive margins (OR = 3.44, 95% CI [1.45, 8.18], P = 0.005). Higher initial PSA level (HR = 2.88, 95% CI [1.04, 7.94], P = 0.041) and positive surgical margin (HR = 2.55, 95% CI [1.20, 5.44], P = 0.015) were poor prognostic factors for BFS.

Conclusion:

RaLRP can be considered among high-risk prostate cancer in Asian people with comparable oncological outcomes to LRP. Higher pathological T stage was associated with increased likelihood of positive margins, patients with higher iPSA level and positive surgical margin had worsen biochemical recurrence-free survival.
Management of Urinary Tract Injuries Following Total Hysterectomy
Authors: Hsu Chao-Yu , Law Kim-Seng , Tai Hao-Ping , Chen Hsiang-Lai , Tse Siu-San , Huang Zhon-Min , Weng Wei-Chun , Huang Li-Hua , Lee I-Yen , Tung Min-Che
Published: November 2021

Objective:

This study elaborated on the clinical experience of patients who underwent urologic management due to urologic complications after receiving a total hysterectomy at a regional hospital.

Materials and methods:

A total of 696 female patients received the four types of total hysterectomy including total abdominal hysterectomy, transvaginal hysterectomy, lapaparoscopic hysterectomy or robotic hysterectomy for variant gynecologic pathologies. Only 22 cases (3.2%) had urologic procedures performed during or after the operations from 2012/1/1 to 2016/6/30.

Results:

Of the 22 cases, thirteen (1.9%) received a series of conservative managements only, including cystoscopy, ureteroscopy, endoscopic ureterotomy, ureteral catheterization or double J stenting during the follow-up period. Nine more complicated cases (1.3%) eventually had definitive management, including repair of the urinary bladder rupture, repair of the vesicovaginal fistula, ureteroureterostomy or ureteroneocystostomy. However, five of these nine cases had both conservative and definitive management. The mean delay interval between the initial management and gynecologic procedure was 19.3 days. For definitive management and the gynecologic procedure, the period was 52.8 days.

Conclusions:

Compared to previous studies, the incidence of urologic injuries following a total hysterectomy in our hospital was similar. From the paper review, it seems early recognition does not improve the outcome but we found a 100% good outcome in patients with definitive management. Copyright © 2017, Taiwan Urological Association. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Long-term Outcomes of Nephrectomy and Inferior Vena Cava Thrombectomy in Patients with Advanced Renal Cell Carcinoma
Authors: Lien Chi-Chih , Liu Kao-Lang , Chou Po-Ming , Lin Wei-Chou , Tai Hui-Ching , Huang Chao-Yuan , Wang Shuo-Meng , Huang Kuo-How , Pu Yeong-Shiau
Published: November 2021

Background/Purpose:

This study evaluated the long-term outcomes of nephrectomy and inferior vena cava (IVC) thrombectomy in patients with advanced renal cell carcinoma (RCC).

Methods:

From January 1996 to December 2013, we retrospectively collected the clinical data of 31 patients with pathologically confirmed RCC and IVC tumor thrombus. All patients received nephrectomy and IVC thrombectomy. We examined the clinical outcomes, including cancer-specific survival, progression-free survival, and postoperative complications, during a 90-day period. The associated prognostic factors were also analyzed. This study is registered with the National Taiwan University Hospital Research Ethics Committee (number 201305059RINC).

Results:

The median follow-up period was 24 months. Of 20 patients with nonmetastatic disease, 15 developed metastases during the study period. The overall 5-year cancer-specific survival rate was 30.8% in the nonmetastatic group versus 12.5% in the metastatic group. The level of IVC thrombus (Levels I–II vs. Levels III–IV) was not significantly associated with the 5-year cancer-specific survival (P = 0.43). The Fuhrman grade and sarcomatoid type were statistically significant predictors of cancer-specific survival (Fuhrman Grades III–IV vs. Grades I–II: Hazard ratio [HR] = 0.11, P = 0.04; sarcomatoid type: HR = 0.136, P = 0.001). Fuhrman grade, capsular invasion, and positive surgical margins were associated with 1-year progression-free survival (Fuhrman Grades III–IV vs. Grades I–II: HR = 0.08, P = 0.04; capsular invasion: HR = 0.15, P = 0.04; positive surgical margins: HR = 0.16, P = 0.05). The most common perioperative complication was massive blood loss. The most common recurrence sites were bones, liver, and lungs.

Conclusion:

The pathologic Fuhrman grade, sarcomatoid type, positive surgical margins, and capsular invasion were significant predictors of oncological outcomes in patients with advanced RCC and IVC thrombus.
Comparative Analysis between Radical Cystectomy and Trimodality Therapy for Clinical Stage II Bladder Cancer
Authors: Hong Jian-Hua , Lin Yu-Hua , Lu Yu-Chuan , Chiang Yun , Tai Huai-Ching , Huang Kuo-How , Cheng Chia-Hsien , Pu Yeong-Shiau
Published: November 2021

Objectives:

To analyze the clinicopathologic characteristics and oncologic outcomes between radical cystectomy (RC) and trimodality therapy (TMT) for patients with clinical stage II bladder urothelial carcinoma (UC).

Methods:

Between January 2004 and September 2013, the medical records of 93 consecutive patients with clinical stage II bladder cancer (cT2N0M0) diagnosed at National Taiwan University Hospital were retrospectively reviewed, including 66 with RC and 27 with TMT. Univariate and multivariate Cox regression analyses were performed to determine prognostic factors.

Results:

The median follow-up time was 34.1 months. There were no significant differences between the TMT and RC group with respect to age, gender, cancer grade and the presence of hydronephrosis. The 5-year overall survival rate (74%) and the 5-year cancer specific survival rate (76%) showed comparable results between RC and TMT group. The overall recurrence rate was 38 % (RC: 41% vs. TMT: 30%, p=0.35). Presence of hydronephrosis demonstrated statistically significant association with tumor recurrence (HR: 2.05, 95% CI 1.04-4.04, p=0.04). Patients with diabetes mellitus (DM) were independently correlated with poorer overall survival (HR: 2.73, 95% CI 1.09-6.82, p= 0.03) and cancer-specific survival (HR: 3.32, 95% CI 1.28-8.65, p= 0.01.)

Conclusions:

TMT is an optimal therapeutic option in selected patients with clinical stage II bladder UC. In our study, despite the method of treatment, presence of hydronephrosis increased cancer recurrence risk and DM demonstrated a significantly negative effect on overall survival and cancer-specific survival.
Videourodynamic Precision Diagnosis and Treatment of Lower Urinary Tract Symptoms in Women
Authors: Kuo Hann-Chorng
Published: November 2021

Lower urinary tract symptoms (LUTSs) in women are common in urological practice but are usually uninformative for diagnosing the underlying lower urinary tract dysfunction. To obtain a precise diagnosis and devise a precise treatment strategy, a videourodynamic study (VUDS) is an essential tool for investigating the bladder and bladder outlet dysfunction, especially when LUTS cannot be relieved after initial medical treatment. An accurate VUDS diagnosis can guide effective treatment and prevent unnecessary or incorrect surgical intervention. This article reviews updated applications of VUDS in the diagnosis and treatment of LUTS in women.
Evaluation of Perioperative Complications and Outcomes of Robot-assisted Radical Nephroureterectomy and Bladder Cuff Excision in a Tertiary Center
Authors: Tai Meng-Che , Chung Hsiao-Jen , Wei Tzu-Chun , Lin Tzu-Ping , Huang Eric Yi-Hsiu , Lu Shing-Hwa , Chang Yen-Hwa , Lin Alex T.L.
Published: November 2021

Purpose:

For patients with localized upper tract urothelial carcinoma (UTUC), radical nephroureterectomy with ipsilateral bladder cuff excision (RNU + BCE) is the standard treatment. In recent years, robot-assisted RNU with BCE (RaRNU + BCE) has been another choice of surgical intervention. This article was aimed to analyze the efficacy and perioperative outcomes regarding RaRNU + BCE through a single institutional experience.

Patients and Methods:

From March 2012 to November 2015, a total of 54 patients with UTUC were treated with RaRNU + BCE at Taipei Veterans General Hospital. We collected demographic data, histopathological reports, perioperative complications, and oncologic outcomes.

Results:

A total of 54 patients were included in our study. The mean age was 71.9 ± 9.9 (range 48–88) and the mean body mass index was 23.5 ± 2.9 (range: 16.4–30.8). The mean operating time was 314 min (RaRNU: 133.9 ± 41.4 min and RaBCE: 72.9 ± 25.7 min). The mean first docking time was 26.8 ± 7.7 min and the mean second docking time was 16.5 ± 6.7 min. The mean EBL was 87.7 ml. Pathological stage distribution was 22.2%, 27.8%, 13.0%, 31.5%, and 5.6% in pTa, pT1, pT2, pT3, and pT4, respectively. Complications occurred in 7 cases (13%), with 4 Grade I and 3 Grade II by Clavien-Dindo classification. Positive tumor involvement at bladder cuff was noted in three patients, and the bladder recurrence rate was 29.6%. Local recurrence, lymph node metastasis, and distant metastasis were all noted for two patients, respectively. The cancer-specific and overall survival rate was 98.1% and 96.3%.

Conclusions:

Our experience showed that RaRNU + BCE is a technically feasible and safe procedure for selected patients with UTUC.
О концентрации значений чисел независимости случайных гиперграфов
Authors: Denisov Ilya Olegovich , Shabanov Dmitry Aleksandrovich
Published: November 2021

В работе исследуется асимптотическое поведение общих чисел независимости случайных гиперграфов в биномиальной модели. Доказано, что в определенной области изменения параметров имеет место предельная концентрация числа независимости в двух соседних значениях.
О разложении многочленов с помощью операции сдвиг-композиции
Authors: Nozdrunov Vladislav Igorevich
Published: November 2021

В работах В.И.Солодовникова при помощи операции сдвиг-композиции были исследованы гомоморфизмы регистров сдвига в линейные автоматы и указаны условия отсутствия нетривиальных внутренних гомоморфизмов регистров сдвига. При этом существенным являлось условие линейности левой компоненты в операции сдвиг-композиции в соответствующем разложении многочлена. В данной работе рассматривается случай, когда левая компонента является функцией из класса, большего по мощности и включающего в себя класс линейных функций.
Восстановление неограниченного входного воздействия системы дифференциальных уравнений
Authors: Maksimov Vyacheslav Ivanovich
Published: November 2021

Рассматривается задача восстановления неограниченного негладкого входного воздействия системы нелинейных по фазовым переменным и линейных по управлению обыкновенных дифференциальных уравнений. Задача имеет две особенности. Во-первых, предполагается, что измеряются (с ошибкой) в дискретные моменты времени фазовые координаты заданной системы. Во-вторых, предполагается, что неизвестное воздействие является элементом пространства функций, суммируемых с квадратом евклидовой нормы, т.е. может быть негладким и неограниченным. С учетом данной особенности задачи конструируется устойчивый к информационным помехам и погрешностям вычислений алгоритм ее решения, основанный на комбинации конструкций теории некорректных задач с известным в позиционных дифференциальных играх методом экстремального сдвига.
Общая теорема о неявной функции для близких отображений
Authors: Avakov Evgeny Rachievich , Magaril-Il'yaev Georgii Georgievich
Published: November 2021

Доказывается теорема достаточно общего вида о существовании неявной функции для отображений, которые близки к исходному в равномерной метрике пространства непрерывных отображений. Выводится важное для приложений следствие, связанное с возмущением линейных отображений.
The translation field in Serbia 1960-1990
Authors: Eraković Borislava
Published: November 2021

The paper presents a chronological overview of diverse translation related activity in Serbia be­tween 1960 and 1990 that led to a successful interplay of four types of perspectives on translation enquiry: Policy, Public, Scientific and Critical (Koskinen 2010). It is based on the data available in periodicals, conference proceedings and other publications issued by two major translator associa­tions and book-length publications on translation theory in Serbia during this period. The analysis presents the events, topics, participants and publications on translation as well as the role of state ideology in the promotion of translation activities. Finally, it is argued that the continuous dialogue between practitioners and scholars on numerous pragmatic questions (translator training, develop­ment of terminologies, the status of the profession and others), as well as on theoretical ones (on the nature of translation theory) led to the emergence of theoretical discourse on translation in Serbia.
Tarihi Yapıların 3 Boyutlu Belgelenme Sürecinde Nokta Bulutu Yönteminin Rolü: Yaylak Ulu Camii Örneği
Authors: ÇALIŞIR Kadir
Published: November 2021

Tarihi yapıların üç boyutlu belgelendirme yöntemleri arasında, hızlı ve doğru veri elde etme özellikleriyle Işık Tespiti ve Mesafe Ölçme (Light Detection and Ranging - LiDAR) sistemleri giderek ön plana çıkmaktadır. Teknolojinin gelişimi ile birlikte özellikle son yıllarda öğrenimi kolay ve kullanıcı dostu olan ara yüzler ile bu ara yüzleri destekleyen yazılımların sayıları giderek artmaktadır. Korunması gereken taşınmaz kültür varlıkları kapsamında olan tarihi yapıların belgelenme sürecinde yersel lazer tarama (YLT) sistemininkullanılması, karmaşık yapıların kısa sürede modellenmesi için umut verici bir teknolojidir.

Bu çalışma kapsamında taşınmaz kültür varlıkları olarak değerlendirilen tarihi eserlerin belgelenmesinin önemi, bu belgeleme sürecinde kullanılan yöntemlerden biri olan yersel lazer tarama sisteminin neden tercih edildiği ve sistem hakkında geniş bir bilgi verilmektedir. Yersel lazer tarama sistemleri ile elde edilen nokta bulutları ile Şanlıurfa ili Bozova ilçesine bağlı Yaylak beldesinde yer alan tarihi Yaylak Ulu Cami’nin 3 boyutlu modeli çıkarılarak belgelenmesi yapılmıştır. Yaylak Ulu Cami’nin 3 boyutlu modelinin oluşturulma sürecinde YLT sistemi ile elde edilen nokta bulutları, ortofoto görüntü verileri kullanılmış olupSCENE yazılımından yararlanılarak 3 boyutlu model oluşturulmuştur.
Ludicidade como estratégia didática no processo de ensino-aprendizagem em bioquímica
Authors: Lima Ketyline Lira de , Calaça Priscilla Régia de Andrade , Moura Yanara Alessandra Santana , Porto Ana Lúcia Figueiredo , Bezerra Raquel Pedrosa
Published: November 2021

Jogos tornam o ensino-aprendizado mais dinâmico e poucos trabalhos sobre o ensino de bioquímica na educação superior com auxílio de jogos são publicados. Neste trabalho objetivou-se conhecer a perspectiva docente sobre jogos no ensino-aprendizagem em bioquímica. A metodologia seguiu viés qualitativo com entrevista a oito professores de bioquímica nos cursos Ciências da Saúde, Ciências Biológicas e Ciências Agrárias de Instituições de Ensino Superior reconhecidas pelo Ministério da Educação. Quatro professores entrevistados não conheciam jogos como ferramenta didática. Contudo, os que utilizaram os jogos relataram melhora na compreensão dos estudantes e maior participação tornando o processo prazeroso. Portanto, são necessários investimentos em produtos e métodos facilitem o ensino-aprendizagem. Jogos são importantes para viabilizar experiências prazerosas e enriquecedoras no ensino de bioquímica.
Centro Oeste Mineiro, biodiversidade e o ensino de biologia
Authors: Silva Thais Ferreira Bessas , Rédua Laís de Souza
Published: November 2021

O presente relato de experiência objetiva produzir uma Bionarrativa Social (BIONAS) em diálogo com temáticas sobre a biodiversidade salientadas em jornais digitais da região de Divinópolis (MG). Assim, foi feito a produção da BIONAS intitulada “Memórias do Rio Itapecerica e os conflitos sobre a água em Divinópolis” e um levantamento das temáticas ambientais em reportagens jornalísticas. A BIONAS traz um conjunto de narrativas envolvendo o principal rio regional, abrangendo questões históricas, culturais, artísticas, científicas e políticas, contribuindo para reflexões sobre a biodiversidade local no ensino de biologia e para resoluções de conflitos socioambientais protagonizados pelos sujeitos locais. Em diálogo com a BIONAS, a temática mais frequente no levantamento foi a questão hídrica, evidenciando um conflito socioambiental sobre a água em Divinópolis e região.
Brazilian Consensus Guidelines for Hematopoietic Stem Cell Transplantation - Inborn errors of metabolismo
Authors: Gomes Alessandra Araujo , Mello Rodrigues Adriana , Folloni Fernandes Juliana , Daudt Liane , Bonfim Carmem
Published: November 2021

Hematopoietic stem cell transplantation (HSCT) has the potential to cure a significant proportion of patients with malignant and nonmalignant diseases. The main rationale for HSCT in inborn errors of metabolism (IEM) is based on correcting the decreases enzymes by the donor cells within and outside the intravascular compartment.

In this article, Brazilian Group for Pediatric Bone Marrow Transplantation of the Brazilian Society of Bone Marrow Transplantation and Cellular Therapy (SBTMO) provides a review of HSCT indications in IEM.
Hematopoietic Stem Cell Transplantation for Pediatric Chronic Myeloid Leukemia
Authors: Vasconcelos Gouveia Roseane , Azenha Milani Soriano Paola , Santos Domingues Luciana , Vaz de Macedo Antonio
Published: November 2021

Chronic myeloid leukemia (CML) accounts for approximately 2 to 3% of all pediatric leukemias. Compared to adults, children tend to present with more aggressive features, such as higher leukocyte counts and massive splenomegaly, and are more likely to be diagnosed with advanced stage disease. Before the advent of tyrosine kinase inhibitors, a couple of decades ago, allogeneic hematopoietic stem cell transplantation (allo-HSCT) was the mainstay of treatment for this disease. This, however, was associated with considerable treatment-related morbidity and mortality. Even so, despite its secondary and somewhat limited indication today, allo-HSCT remains an important alternative and the only curative treatment for CML. In 2020, the Brazilian Group for Pediatric Bone Marrow Transplantation of the Brazilian Society for Blood and Marrow Transplantation and Cellular Therapy (SBTMO) convened a task force to provide evidence-based guidance on the use of allo-HSCT for the appropriate management of childhood CML, the results of which are presented here.
Hematopoietic Stem Cell Transplantation for Pediatric Acute Lymphoblastic Leukemia - SBTMO/SOPOBE 2020 Consensus Guidelines
Authors: Daudt Liane Esteves , Macedo Antonio Vaz de , Guimaraes Renata Fittipaldi , Fernandes Junior Virginio Climaco de Araujo , Colturato Maura R V Ikoma , Castro Junior Claudio Galvão de , Domingues Luciana dos Santos , Seber Adriana
Published: November 2021

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative approach to children and adolescents with high-risk acute lymphoblastic leukemia (ALL) at diagnosis or relapsed disease. Nonetheless, despite the graft versus leukemia (GVL) effect, treatment-related morbidity and mortality remains a major challenge. Moreover, the significant heterogeneity of the available data on the selection of patients, type of conditioning regimen, and type of donor hampers any definitive conclusions in the pediatric population. In 2020, the Brazilian Group for Pediatric Bone Marrow Transplantation of the Brazilian Society of Bone Marrow Transplantation and Cellular Therapy (SBTMO) and the Brazilian Society for Pediatric Oncology (SOBOPE) convened a task force to provide general guidance on HSCT for childhood ALL to providing evidence-based guidance for the appropriate management of this disease.
Long-Term Follow-Up of Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation
Authors: Lopes Garcia Júlia , Vaz de Macedo Antonio , Dorini Pelegrina Polliany Roberta , Barbosa Tavares Rita de Cássia , Vasconcelos Gouveia Roseane , Seber Adriana
Published: November 2021

Hematopoietic stem cell transplantation (HSCT) offers the opportunity for cure to patients with malignant and non-malignant diseases. Given the myriad advances in the past few decades, coupled with the rising numbers of transplants worldwide, the number of long-term survivors, many of whom are free of the disease for which they were transplanted, is constantly increasing. Despite the improved prognosis observed overall, long-term outcome may be undermined by transplant-associated morbidity and mortality. Long-term survivors may present a variety of complications, comprising physical, psychological, social, and economic arenas, with a deep impact on quality of life. Therefore, drawing greater attention to and raising awareness of the potential long-term effects of HSCT is key to providing a tailored approach to pretransplant counseling and to devising appropriate recommendations for post-transplant screening, prevention, and timely treatment of secondary events. In 2020, the Brazilian Group for Pediatric Bone Marrow Transplantation of the Brazilian Society for Blood and Marrow Transplantation and Cellular Therapy (SBTMO) convened a task force to provide updated, evidence-based guidance for the long- term follow-up of pediatric patients undergoing HSCT, the results of which are presented here.
AS PESQUISAS EM ENSINO DE GEOGRAFIA E A CATEGORIA ESPACIAL DE PAISAGEM:
Authors: Fonseca Ricardo Lopes
Published: November 2021

Neste texto é apresentado o Estado da Arte das pesquisas em ensino de Geografia que abordaram a categoria espacial de paisagem, a partir da análise dos artigos publicados em periódicos nacionais, considerando toda a série histórica disponível de forma on-line até o ano de 2016. O objetivo é investigar, a partir das publicações de artigos em periódicos nacionais on-line possibilitando inferir acerca das perspectivas e das tendências das pesquisas no ensino de Geografia que versaram a respeito da paisagem. Foram localizados 1.458 artigos acerca do ensino de Geografia, sendo 35 destes referentes à paisagem, em 187 periódicos avaliados na área de Geografia, considerando-se o Qualis Periódicos quadriênio 2013-2016. Os resultados estão discutidos em dois momentos, o primeiro como um perfil quantitativo e o segundo a partir do tratamento qualitativo, por meio do método de Análise de Conteúdo, de Bardin (1977). Por fim, por ser considerada uma atividade árdua e complexa, o Estado da Arte desenvolve uma ação bastante criteriosa e reflexiva.
Palavras-chave
Paisagem, Pesquisa, Estado da Arte, Ensino de Geografia, Epistemologia.
 

RESEARCH IN TEACHING GEOGRAPHY AND THE SPACE CATEGORY LANDSCAPE: notes from a literature review

This paper presents a literature review about on teaching Geography from the analysis of articles about landscape published in national journals, considering the entire historical series until 2016, that is available online. The objective is to investigate, from the publication of articles in national journals online, the entire historical series, allowing to infer about the perspectives and trends of research on place. We found 1,458 articles on this theme, 35 of which refer to the landscape, in 187 journals evaluated in the Geography area, considering the Qualis Periodicals quadrennium 2013-2016. The results were discussed in two moments, the first from a quantitative profile and the second as a qualitative treatment, using Bardin's Content Analysis method (1977). Research on the State of the Art has critical and reflective character that assist in the development of new research demands, concepts and paradigms.
Keywords
Landscape, Research, Literature review, Teaching Geography, Epistemology.
A DSGE model with partial euroization: the case of the Macedonian economy
Authors:   National Bank of Romania, Copaciu Mihai , Madjoska Joana ,   National Bank of the Republic of North Macedonia, Miteski Mite ,   National Bank of the Republic of North Macedonia
Published: November 2021

This paper describes the theoretical structure and estimation results for a DSGE model for the Macedonian economy. Having as benchmark the model of Copaciu et al. (2015), modified to allow for a fixed exchange rate, we are able to match relatively well the volatility observed in the data. Given the monetary policy regime in place, the debt deflation channel is more important relative to the financial accelerator one when compared to the flexible exchange rate case. The lack of balance sheet effects results in no significant differences in terms of net worth evolution across the two types of entrepreneurs when impulse response functions are evaluated. However, the shocks related to the financial sector appear to be especially important for investment, for the domestic interest rate and interest rate spreads, illustrating the relevance of including financial frictions in the model. With the exchange rate not acting as a shock absorber, the external shocks are more relevant for the CPI inflation and the domestic interest rate. The drop in GDP associated with the pandemic mainly reflects the negative innovations to the consumption preference shock and to the permanent technology shock.
Gingival Pyogenic Granuloma -Clinical Case Report
Authors:   Reader, Department of Periodontics Santosh Dental College, Ghaziabad, Aggarwal Dr. Priyanka
Published: November 2021

Pyogenic granuloma is a vascularized non neoplastic lesion, in the oral cavity, caused by trauma, local irritants or hormonal factors, with a higher prevalence in women, present more frequently in the mandible than in the maxilla. It is not associated with pus as its name suggests and histologically it resembles an angiomatous lesion rather than a granulomatous lesion. It is known by a variety of names such as Crocker and Hartzell’s disease, granuloma pyogenicum, granuloma pediculatum benignum, benign vascular tumor and during pregnancy as granuloma gravidarum Treatment consists of removal of local irritant, if any followed by excisional biopsy. This clinical case report presents the clinical and histopathological characteristics of the large pyogenic granuloma in a 36-year-old female, who reported to the Department of Santosh Dental College, Ghaziabad. Intraoral examination revealed a lesion mainly non tender, sessile, soft in consistency and measuring approximately 16by 9 mm in diameter in the posterior side of maxillary first quadrant. Keeping in view the characteristics of the lesion, anamnesis and the literature, the pyogenic granuloma and giant cell granuloma were defined as diagnostic hypotheses. Excisional biopsy was done and specimen was sent for histopathological evaluation.
Adoption of Team Coaching Competencies for Innovative Translation and Foreign Language Instruction: Polylingual and Polycultural Dimensions in Higher Education
Authors:   National University of Life and Environmental Sciences of Ukraine, 15, Heroyiv Oborony St., Kyiv 03041, Ukraine, Chaika Oksana
Published: November 2021

The contemporary world is subject to waves of highly rated turbulences and demand volatility in the market of educational services. In the recent decades, Ukraine as a developing state has witnessed varied response from educators, students, observers, bloggers as to the content and quality of education. The paper aims to elaborate the surface scratching recommendations for the development of an educational policy, which may be eligible for adoption at universities, endorsing modernisation of content and structure of higher education inside and outside Ukraine by means of developing, growing and applying coaching mind-set for teaching and learning processes. First, this refers to growing efficiency in communication models by foreign language (FL) teachers (irrespective of the field) and foreign language instructors (teaching foreign languages, languages for specific purposes in foreign languages, and translation) in giving lectures and moderating polycultural and polylingual classes. Second, it links to fostering culturological, axiological, intercommunicative values for polycultural communication in various languages, if applicable, between the teacher and the student and vice versa, the teacher and the teacher, the student and the student, etc. Team coaching may be treated one of the fastest growing disciplines in the coaching profession; and for the higher education, it is becoming increasingly important Team coaching competencies as hard skill of a modern FL / LSP teacher may enable a U-turn in the educational market as viewed in the light of demotivated students, losing interest in an academic degree, or gaining qualifications within the university walls. Team coaching defined as partnering in a co-creative and reflective process with a team (class) on its dynamics and relationships in a way that inspires them to maximize their abilities and potential in order to reach their common purpose and shared goals, may well fit into class instruction of the modern era.
Time-Series Statistical Model for Forecasting Revenue and Risk Management
Authors: Kelkar Mihir , Borsa Cosmin , Kim Lina
Published: November 2021

Following a Low-Cost Carrier (LCC) model, Southwest Airlines has consistently demonstrated growing annual revenues up until the start of the COVID-19 pandemic. Southwest’s quarterly revenue shows that there exists a strong seasonal component with the revenue in the first quarter of the fiscal year (September) significantly higher than other quarters. Using the quarterly revenue data we constructed a time-series model: a seasonal autoregressive integrated moving average (SARIMA) model to forecast Southwest’s revenue over 2020. We then performed a cost and solvency risk analysis using the company’s financial results from its annual reports to analyze Southwest’s financial performance due to COVID-19, and proposed business strategies to keep Southwest financially stable.
STUDY OF THE ANTIHELMINTH PROPERTIES OF COMMON TANSY IN HETERACIDOSIS AND CAPILLARIOSIS OF TURKEYS
Authors: Saroka A. M.
Published: November 2021

The helminthic diseases of birds are widespread and cause great economic damage. Deworming of birds is one of the effective measures to combat them. For these purposes, mainly chemical synthesis preparations are used. It is established that some plants have antiparasitic properties, among them − Tanacetum vulgare L., widely spread in natural agrophytocoenoses of the Republic of Belarus. Antihelminthic properties of this plant have been studied during heterakidosis and capillaryosis disease of turkeys.

Experience in studying parasitocidal activity of powder from the inflorescences of Tanacetum vulgare L. was conducted on turkeys spontaneously invaded by capillaries and heterakids. It was found out that this preparation is an effective antihelminthic remedy providing complete release of turkeys from nematodes.
CURATIVE AND PROPHYLACTIC FEATURES OF ALECOST (TANACETUM VULGARE L.) FOR LAMBS WITH CRYPTOSPORIDIOSIS
Authors: Starovoitova M. V.
Published: November 2021

The medicinal and prophylactic properties of powder from inflorescences of common tansy for cryptosporidiosis of lambs were studied. Recommended for use in lambs as an anti-cryptosporidiosis agent.
The Effects of Performance Expectancy, Effort Expectancy, Facilitating Condition, and Habit on Behavior Intention in Using Mobile Healthcare Application
Authors: Utomo Prio , Kurniasari Florentina , Purnamaningsih Purnamaningsih
Published: November 2021

South Tangerang Health Office had the responsibility in giving outstanding healthcare services to its resident’s despite of its limitation due Covid-19 pandemic. Some programs were initiated to reduce maternal, babies and toddler mortality, and in the same time reduce the number of malnourished children. The integrated healthcare mobile application called Si Pandai Kemas TangSel had been launched and can be downloaded easily through smartphone. The study is expected to measure the effectiveness of Si Pandai Kemas TangSel using UTAUT approach by measuring the influence of performance expectancy, effort expectancy, facilitating condition and habit toward behavior intention in using Si Pandai Kemas TangSel mobile application. The study showed that the effort expectancy and habit can increase the intention to use Si Pandai Kemas TangSel application. Meanwhile, performance expectancy and facilitating conditions did not affect behavioral intention in using Si Pandai Kemas TangSel application.
Relationship between Madrasah Head Leadership and Teacher Performance
Authors: Islahuddin Islahuddin , Wildan Wildan , Baehaqi Baehaqi
Published: November 2021

The purpose of this study is to find out the relationship between the leadership of the head of Madrasah Ibtidaiyah and the performance of Madrasah teachers in Lingsar District of West Lombok Regency in 2021. This research is quantitative research using survey methods. The population in this study is all teachers in madrasah-Ibtidaiyah in Lingsar district of West Lombok Regency which amounted to 102 teachers. This research sample amounted to 50 teachers spread across Ibtidaiyah madrassa of Lingsar District of West Lombok Regency. The data analysis technique used in this study is regression analysis, both simple regression and double regression. The results showed that there was a positive and significant relationship between the leadership of the head of Madrasah Ibtidaiyah and the performance of Madrasah Ibtidaiyah teachers in Kacamatan Lingsar West Lombok Regency with a contribution of 57%.
Equality without equity: The gender pay gap at the National University of Colombia
Authors: Neira Carolina , Rodríguez Eduardo , Valdés Álvaro
Published: November 2021

The National University of Colombia boasts a clear and egalitarian salary regime for its academic staff. Apart from rules concerning maternity and paternity leaves, which follow national Colombian legislation, the Academic Personal Statute is completely free of gender-based norms. Salaries are assigned through a points system that considers training level, productivity, and academic rank. With this in mind, one might expect to find egalitarian male and female salary conditions free of the gender-related gaps existing in other, more arbitrary private work environments. In this article, we present the results of a variance decomposition analysis of the gross salaries of all full-time professors and report the existence of an unadjusted gender pay gap of 0.12 and adjusted or unexplained gaps of 0.07-0.09 obtained through a Mincer earnings regression and a Blinder-Oaxaca decomposition. Partial correlations between these gaps and the different factors that come into play are examined and analyzed. The high impact of professors’ research track record on their salaries appears as the main contribution to the gender differences. It seems plausible that the crucial need for time to dedicate to research opens the window to the patriarchal society to permeate the otherwise egalitarian salary regime of the University, especially for the highest range of salaries corresponding mainly to male full professors who are very active in research.
FAMILY PLANNING KNOWLEDGE, ATTITUDE AND PRACTICE AMONG WOMEN OF REPRODUCTIVE AGE IN NIMULE PAYAM, SOUTH SUDAN
Authors: Drici Andrew , Eremugo Isaac , Akello Sarah , Andinda Maureen
Published: November 2021

Purpose: The purpose of this study was to examine family planning Knowledge, Attitude and Practice (KAP) among women of reproductive age in Nimule Payam, South Sudan.

Method: The study used a descriptive cross-sectional design and quantitative approach to explore family planning knowledge, attitude and practice among women of reproductive age in Nimule Payam. The study population consisted of 6,621 women of reproductive age in the Bomas of Anzara (1,930), Jalei(,1521), Olikwi (1,536) and Nimule Central (1,634). A sample size of 342 was determined from the population using the formulae of Leslie. Stratified simple random sampling was employed through a researcher administered structured questionnaire to collect data from the respondents. The data was cleaned, coded and analyzed using EPI-INFO version 7 to generate descriptive statistics and the results were presented in tables.

Results: The study revealed that women of reproductive age in Nimule Payam had high 273 (79.82%) level of family planning knowledge, good 233 (68%) family planning practices and positive attitude towards family planning. The positive attitude towards family planning was because majority 270 (78.97%) believed family planning was safe to use, could not cause infertility 252 (73.82%), cancer 264 (76.93%) and future abortion 251 (73.36%). The respondents also generally agreed that 319 (93.07%) family planning could prevent unwanted pregnancy. However, the majority of the respondents acknowledged that the practice of family planning was against their God/Allah 268 (78.31%) and culture 229 (67.03%).

Unique contribution to theory, practice and policy: The study found that women of reproductive age in Nimule Payam had a high level of family planning knowledge, a fairly positive attitude with a moderate number practicing family planning methods. Increased sensitization of the respondents and their partners on family planning is required to improve their attitude and practice. Future studies should focus on the factors influencing the Knowledge, Attitude and Practice of family planning methods among women of reproductive age in Nimule Payam.