bluuebunny/crossref_metadata_2025 huggingface dataset:
Perlindungan Hukum bagi Debitor di Indonesia Sehubungan Tidak Adanya Insolvency Test
Authors: Aprita Serlika
Published: March 2023

The embodiment of legal protection for debtors whose companies still have the prospect of continuing but the debtor's financial condition in a state of inability to pay must be declared bankrupt due to the absence of an insolvency test which is considered contrary to the application of the going concern principle, which is related to the existence of expectations regarding the concept of the Indonesian Bankruptcy Law. in the future, especially regarding the shift in the purpose of the Bankruptcy Law, where initially the Bankruptcy Law aimed to liquidate debtor's assets, so it is hoped that in the future the Bankruptcy Law will in its development change as a means of reorganizing debtors in continuing their business activities, where this goal is not embodied in Law Number 37 of 2004 concerning Bankruptcy and PKPU.
Bhinneka Tunggal Ika Sebagai Pilar Kebangsaan Indonesia
Authors: Yunus Nur Rohim
Published: March 2023

Landasan Nasional Pancasila dan HUT RI merupakan bagian yang tidak terpisahkan dari Bhinneka Tunggal Ika dan tidak dapat dipisahkan satu sama lain. Hal ini sejalan dengan unsur-unsur yang terkandung dalam lambang negara Indonesia. Garuda dengan kepala menoleh ke kanan, perisai berbentuk hati yang tergantung di leher garuda dan semboyan yang tertulis di pita yang dipegang garuda adalah tiga komponen yang membentuk lambang negara, sebagaimana tercantum dalam Pasal 1 Tahun 1951 Peraturan Pemerintah Nomor 66 Tahun 2009. Ungkapan "BHINNEKA TUNGGAL IKA" dicetak dalam bahasa Jawa Kuno pada pita dengan huruf latin. Ini adalah moto Kebangsaan Indonesia.
Respon Vanuatu Terhadap Konflik Kekerasan dan Pelanggaran Hak Asasi Manusia Di Papua
Authors: Nujud Yasub Atsyir
Published: March 2023

This research aims to provide a depiction of two views, namely about Vanuatu's role in West Papua's independence and addressing the problems that occur in West Papua related to violence and human rights. Specifically, this study aims to find out (a.) the response provided by the United Nations Human Rights Commission. The research method that the author uses in achieving the purpose of this research is with descriptive research methods with the technique of collecting data through literature studies sourced from books, journals, documents, and valid websites. The results of this study explain how the mass media itself in providing and presenting news to the audience related to the existing responses related to the desire for independence of West Papua from NKRI and how the world responds to human rights-related problems.
Pengaruh Perang Dunia Kedua Terhadap Kemajuan Jepang pasca Perang Dingin
Authors: Sari Suniyyah Puspita , Fatimatuzzahra Ulya
Published: March 2023

The end of World War II led to several changes to the global world order, including japan. The often inferior eastern country motivated Japan to make some progress for its country in World War II, but its defeat led to its misfortune as well as its fortune as a superpower in the field of industrial technology. The economy is the most targeted by the Japanese state in building the progress of the country, especially in the field of science and industrial technology. Post-World War II Japan also experienced changes in Japan's post-World War II Foreign Policy, stemming from several doctrines produced by its Prime Minister, such as the Yoshida Doctrine which focused on economic development, then there was the Fukuda Doctrine which focused on Japanese foreign policy to Southeast Asia. Japan's progress in competing with other western countries, is also supported by the principle of group work and the delivery of a number of academics who are ready to serve their country.
Analysis of Germany's Political Economy During Adolf Hitler's Presidency
Authors: Salsabilla Annisa , Zuhriyah Aminatuz
Published: March 2023

German rule under Adolf Hitler lasted from 1930 to 1944. The prime minister embraced fascism. Fascism is a chisel of extreme nationalism that wants authoritarian rule. Fascism encompasses the theories as well as practices on the political, social, and economic systems of fascist parties in Germany. In a fascist system, everyone must submit to the State, the party-centered government, industry, trade, and companies remain under private but are closely monitored by the government, speech habits, the press, etc. are severely restricted. The study aims to find out Adolf Hitler's political strategy to boost Germany's post-world war 1 economy. The research methods used are historical approach. These historical research steps include: heuristic, criticism, interpretation, and historiography. While the data collection technique used in this study is a literature study. The first policy taken by Adolf Hitler's government in leading Germany was to expand its expansion to attack Poland and the Balkan countries, and the other policy was to join the Axis alliance group and engage in World War II against the U.S.-led allied group.
Filsafat Hukum Sejarah: Konsep dan Aktualisasinya Dalam Hukum Indonesia
Authors: Rahmatullah Indra
Published: March 2023

Abstract: Society has  own legal system, namely customary law which can be a source of national law. It exists and has been legitimized in the Indonesian constitution. With the recognition of customary law, law enforcers and lawmakers must consider it. Customary law is not made by the State, but exists, and develops with the development of society. In certain areas, the application of customary law or compliance with customary law is more binding than state law. The basic concept of customary law is from the thought of Friedrick Karl von Savigny through his various works, thus making him the philosopher who built the foundation for the School of Legal History. Keywords: Society; Customary Law; Legal History
Agama sebagai Pilar Kebangsaan Indonesia
Authors: Yunus Nur Rohim
Published: March 2023

Agama merupakan pedoman hidup keseharian rakyat Indonesia. Tanpa agama maka seseorang tidak dapat hidup sebagai warga negara Indonesia, karena jiwa bangsa Indonesia adalah masyarakat religious yang percaya akan adanya Tuhan yang Maha Esa. Oleh karenanya pandangan hidup masyarakat Indonesia harus dilandasi dengan semangat beragama yang mengajarkan kebeneran dan toleransi terhadap pemeluk agama lain.
Zemenfes Tsighe, Saleh Mahmud Idris, Yonas Mesfun Asfaha, Senai Woldeab Andemariam, Rediet Kifle Taddese, Ghebrebrhan Ogubazghi, eds, International Conference on Eritrean Studies, 20–22 July 2016: Proceedings
Authors: Nosnitsin Denis
Published: March 2023

Review
The Gǝʿǝz Manuscripts Collection from the Monastery of Däbrä Ṣǝyon (Abunä Abrǝham, Tǝgray, Ethiopia)
Authors: Abrha Abay Hagos
Published: March 2023

The monastery of Däbrä Ṣǝyon (Abunä Abrǝham), situated on a peak of the eastern chains of the Gärʿalta mountains, is one of the well-known medieval Ethiopian monasteries. It is said to have been established in the fourteenth century by St Abrǝham of Tǝgray. According to his own gädl, Abunä Abrǝham was not only the founder of the monastery, but was also known to be an active participant and director of the architectural work of the rock-hewn church. It is known that Gärʿalta is endowed with reflections of Aksumite culture, and the monastery of Däbrä Ṣǝyon also seems to have had its own share in its continuation. Many places and monasteries (in Tǝgray) are linked to this monastery in terms of shared monastic culture and land granting. Däbrä Ṣǝyon is a rock-hewn church in which many Christian historical artefacts have been preserved. Among the non-codex written artefacts, it has preserved, in particular, a ṭawos manuscript. Seventy-two Gǝʿǝz manuscripts, most of which of hagiographical and liturgical genre, are kept in the church. All were digitized, foliated, with quire number and structure sorted out in 2018, via a project carried out by the St Yared Center for Ethiopian Philology and Manuscript Studies (SYCEPMS) of Mekelle University. Material, physical, and chemical analysis of the manuscripts was not applied due to a lack of equipment and skill. The manuscripts are now in the process of being catalogued and examined for dating, and the article provides a synthetic survey of the whole collection. The ṭawos manuscript, that is, a peacock-type manuscript from the fifteenth century, is part of the collection; its format calls for consideration regarding the definition and significance of a special style of Ethiopic manuscript culture. As a result, this article aims at introducing the monastery and its manuscript collection.
New Readings and Interpretations on the Inscribed Stele from Ḥənzat (HS1)
Authors: Bulakh Maria , Yohannes Gebre Selassie
Published: March 2023

In 1974 the renowned Ethiopianist Lanfranco Ricci inspected the site of Ḥǝnzat in central Tǝgray. Inter alia, he inspected and photographed a stele with a lengthy inscription. In 2014, Yohannes Gebre Selassie published an article on an inscription which he labelled HS1, and which he believed to be a second inscription on a stele found in Ḥǝnzat. However, close inspection reveals that HS1 is the same stele which Ricci saw and described. The contribution here presents evidence to support this claim. In addition, some new interpretations are offered as alternatives to Yohannes Gebre Selassie’s first translation.
Marie-Laure Derat, L’énigme d’une dynastie sainte et usurpatrice dans le royaume chrétien d’Éthiopie du XIe au XIIIe siècle
Authors: Valieva Nafisa
Published: March 2023

Review
Yoḥannǝs IV and the Patriarchate of Alexandria: Obtaining Four Coptic Bishops while Ceding Nothing on Jerusalem Issue (1876–1882)
Authors: Ancel Stéphane
Published: March 2023

This article connects two events that occurred in 1881: the arrival of four Coptic bishops in Ethiopia and the attempt by the Copts to remodel the Dayr al-Sulṭān monastery in Jerusalem. First, connecting these two events contradicts the idea that the Copts agreed to appoint four bishops without any compensation—on the contrary they sought a compensation in Jerusalem. Second, it sheds light on Yoḥannǝs’s diplomatic policy, which enabled him to thwart the Coptic ambitions in Jerusalem and to kill two birds with one stone: he obtained four Coptic bishops, while preserving the rights of the Ethiopians in Jerusalem, and this without any compensation to be given in exchange to the Copts or anyone else. This article shows that behind a friendship demonstrated at the time by Ethiopians and Copts were hidden elements of deep discord. It therefore suggests the need, in the future, to rethink the place to be given to the 1881 agreement in the history of relations between Copts and Ethiopians and its influence on subsequent events.
Melaku Geboye Desta, Dereje Feyissa Dori, and Mamo Esmelealem Mihretu, eds, Ethiopia in the Wake of Political Reforms
Authors: Howard Sarah
Published: March 2023

Review
The Confession of King Gälawdewos (r. 1540–1559): A Sixteenth-Century Ethiopian Monophysite Document against Jesuit Proselytism
Authors: Solomon Gebreyes Beyene
Published: March 2023

The Jesuit mission in Ethiopia represented one of the most serious challenges of Ethiopian Christianity during the early modern times. The mission had two phases. In the first phase, from 1555 to 1603, the missionaries undertook to convert King Gälawdewos and his court in return for military support from Portugal but had to face opposition from his successor, Minas (r.1559–1563). The second period ran from 1603 to 1632 and marked the major success of the mission. The missionaries managed to convert King Susənyos (r.1607–1632) as well as important nobles and dignitaries. In the first phase of the mission, even though the Christian kingdom had been heavily weakened by the wars with Imām Aḥmad b. Ibrāhīm al-Ġazī, called ‘Grañ’ by Christians, the political and religious leaders resolutely opposed Jesuit proselytism. Their opposition took the form of theological debates, wherein local religious leaders, including the ruler, confronted the foreigners and their alien dogmas. In this paper, I will analyse a contemporary Ethiopian religious text popularly known as the Confession of King Gälawdewos. The piece was composed in 1555 under the order of Gälawdewos to face the Jesuit challenge. The paper will show that this important literary work was instrumental in defending the indigenous Orthodox religion and local customs.
Annegret Marx, When Images Travel to Ethiopia … Impact of the Evangelium Arabicum printed 1590 in Rome on a 17th Century Ethiopian Gospel: Documentation and Synoptic Presentation of their Images
Authors: Gnisci Jacopo
Published: March 2023

Review
Meron T. Gebreananye, Logan Williams, and Francis Watson, eds, Beyond Canon: Early Christianity and the Ethiopic Textual Tradition
Authors: Samuelson Calum
Published: March 2023

Review
Critical Edition (with translation) and Textual Analysis of Gädlä Yǝmʕatta
Authors: Abrha Abay Hagos
Published: March 2023

Dissertation abstract
Bibliography of Ethiopian Semitic, Cushitic, and Omotic Linguistics XXV: 2021
Authors: Bulakh Maria , Krżyzanowska Magdalena , Panini Francesca
Published: March 2023

Bibliography of Ethiopian Semitic, Cushitic, and Omotic Linguistics XXV: 2021
Le texte syriaque de la ṭablītō éthiopienne : une réponse aux remarques du Pr. Dr. Michael Waltisberg
Authors: Desreumaux Alain
Published: March 2023

We thank Prof. Dr Waltisberg for his correction of vocalization and for his grammatical contribution. He confirms the unusual form of the verb in the formula and the meaning of bad as a shortcut of which he lists many examples. We take this opportunity to add three Maronite ṭablyōtō found in Lebanon.
Aaron Michael Butts, new Professor of Semitic Studies with a focus on Ethiopian and Eritrean studies at Universität Hamburg, with the project BeInf—Beyond Influence: The Connected Histories of Ethiopic and Syriac Christianity
Authors: Butts Aaron
Published: March 2023

Academic News
Static analysis for languages with exception handling
Authors: Afanasyev Vitaly Olegovich , Dvortsova Varvara Viktorovna , Borodin Alexey Evgenevich
Published: March 2023

This paper describes static analysis for the languages with exception handling. A low level intermediate representation, which supports exceptions, is proposed in this study. Data flow analyses for unreachable code detection were described. А general scheme of static analysis that takes exception related paths into account was given. The algorithms were implemented as a part of the static analysis tool Svace for C++, Java and Kotlin languages.
Automatic data labeling for document image segmentation using deep neural networks
Authors: Mikhaylov Andrey Anatolievitch
Published: March 2023

The article proposes a new method for automatic data annotation for solving the problem of document image segmentation using deep object detection neural networks. The format of marked PDF files is considered as the initial data for markup. The peculiarity of this format is that it includes hidden marks that describe the logical and physical structure of the document. To extract them, a tool has been developed that simulates the operation of a stack-based printing machine according to the PDF format specification. For each page of the document, an image and annotation are generated in PASCAL VOC format. The classes and coordinates of the bounding boxes are calculated during the interpretation of the labeled PDF file based on the labels. To test the method, a collection of marked up PDF files was formed from which images of document pages and annotations for three segmentation classes (text, table, figure) were automatically obtained. Based on these data, a neural network of the EfficientDet D2 architecture was trained. The model was tested on manually labeled data from the same domain, which confirmed the effectiveness of using automatically generated data for solving applied problems.
Irbis: static taint analyzer for vulnerabilities detection in C/C++
Authors: Shimchik Nikita Vladimirovich , Ignatyev Valery Nikolayevich , Belevantsev Andrey Andreevich
Published: March 2023

Static taint analysis can be used to find various security weaknesses and vulnerabilities in programs by discovering dataflow paths from taint sources to taint sinks. In most cases the data is called ”tainted” if it was obtained from an untrusted source without proper sanitization. In this paper we present a static taint analyzer Irbis. It implements analysis based on IFDS (Interprocedural Finite Distributive Subset) dataflow problem, as well as various extensions aimed at improving accuracy and completeness of the analysis. It supports different definitions of tainted data, which enables it to find such weaknesses as out of buffer access, use of freed memory, hardcoded passwords, data leaks and discover dataflow paths between user-defined sources and sinks. All sources, sinks and propagators definitions are stored in JSON format and can be adjusted to meet the users’ needs. We compare analysis results on Juliet Test Suite for C/C++ with several other analyzers, such as Infer, Clang Static Analyzer and Svace. Irbis manages to demonstrate 100% coverage on taint-related subset of tests for implemented CWEs, while suppressing all the false positives using heuristics. We also show performance and false positive rate on real projects, with examples of real vulnerabilities, which can be detected by Irbis.
Mathematical and software models of technical vision tasks of robotic complexes based on “Elbrus” microprocessors
Authors: Bocharov Nikita Alekseevich , Paramonov Nikolay Borisovich , Slavin Oleg Anatolyevich , Suminov Konstantin Alexandrovich
Published: March 2023

The creation of new generations of autonomous robotic complexes, recognition systems and vision systems in general is impossible without the use of modern computer technologies. This article presents models of the robot vision system based on Elbrus microprocessors. Models of detection, classification and segmentation tasks were developed. The models are based on the number of arithmetic operations required to perform a forward pass. The models take into account such features of Elbrus microprocessors as: number of executing devices, pipeline, data pre-pumping, clock frequency, etc. Theoretical and experimental results were obtained on existing and promising "Elbrus" microprocessors. It is shown that Elbrus microprocessors can be the basis of an on-board vision system. The results obtained by the authors indicate the prospects of import substitution in the field of robotics.
HOW DO YOU FIND OUT IF THE PRICE YOU HAVE SET IS CORRECT?
Authors: Kostova Iv.
Published: March 2023

Business owners should look at it as a struggle of views. Customers strive to reduce everything to the simplest possible comparable level. Businesses, on the other hand, must strive to prevent this. If the prevention process is successful, the customer cannot make a reasonable comparison based on price alone. Create in the customer's mind the feeling that the business, product or service is different and success in the long run can be yours. Create in the client a sense of differences that have real value for him. The article has examples of perceived value and how it can be converted into better prices and greater profits. Before we can follow this topic, we need to know if pricing is an issue in your business. This article shows you several ways to find out if your prices are too low.
CORRELATION OF THE BALL SPEED AND RELATIVE STRENGTH POTENTIAL AND EXPLOSIVE POWER OF THE LOWER LIMBS OF IN-STEP KICK OF ELITE FOOTBALL PLAYERS
Authors: Gadev M. , Peev P.
Published: March 2023

The purpose of this study was to reveal the significance of the strength component of major muscle groups and explosive power of lower limbs of elite football players in relation to ball speed upon execution of in-step kick. Methods The research was done among 42 football players aged between 18 and 19 years. The following methods were used: speed metric, tensometry, and dynamometry. The data were processed with math-statistical methods (descriptive statistics and correlation analyses). Results The structural interdependencies between different indicators influencing ball speed were revealed. The data analysis established a strong direct ratio correlation dependence between ball speed and the relative strength of hip muscles of left and right legs (r=0,703 and r=0,720 respectively). We found that the strength component affecting ball speed was more significantly influenced by the relative strength of the muscles of the hip flexors and less influenced by those of the hip extensors. There was a strong interdependence with speed-strength abilities which are related to the magnitude of the power.
Conclusions All in all, we believe that the revealed specifics and guidelines for strength and explosive power influence in conditional training sessions will help increase ball speed upon execution of in-step kick.
DYNAMIC CHANGES IN THE TERRITORIAL AND SECTORAL STRUCTURE OF EMPLOYMENT IN BULGARIA
Authors: Stoycheva Iv.
Published: March 2023

The present study aims to determine the efficiency of a given industry in the regions of the country by identifying the sectors for which comparative advantages can be derived. This study will focus on the dynamic changes in the territorial and sectoral structure of employment, as those sectors that have the potential for development have been determined through defined criteria. The localization coefficient is used to determine the industries with a high degree of concentration and the effect of national and regional trends on the industry structure is established through a “shift-share” analysis of employment. As a result of the analysis, the need to increase the efficiency of the industries, for which the region has comparative advantages, is highlighted, as this is a prerequisite for increasing its competitiveness. The impact on the industries identified in the development in the direction of stimulation would have a favorable effect on the growth of the economy in the region, respectively on the economy of the country as a whole.
Menyingkap Polemik Historisitas Tafsir Corak Lughawi
Authors: Putriyani Siti Nur Umdati , Qalbah Ira Nazhifatul
Published: March 2023

Tafsir lughawi merupakan ittijah yang dilakukan oleh seorang mufasir ketika menjelaskan suatu makna yang terkandung dalam berbagai ayat Al-Qur’an melalui pendekatan bahasa Arab. Latar belakang metode yang digunakan mufasir dalam tafsir lughawi yaitu tahlili-tajzi’i, dengan meliputi etimologis, leksikal, morfologis, retorikal, serta gramatikal. Tujuan penelitian ini yaitu untuk mengetahui perkembangan tafsir lughawi beserta berbagai polemik ulama di dalamnya. Metode penelitian yang digunakan yaitu deskriptif kualitatif dengan jenis penelitian studi pustaka. Hasil penelitian ini yaitu untuk mengetahui bahwa tafsir lughawi memiliki sejarahnya sendiri seiring dengan sejarah pertumbuhan dan perkembangan ilmu bahasa Arab. Secara embrional, tafsir lughawi sudah mulai tumbuh pada masa kenabian, terutama pada periode Madinah. Pada periode ini, umat Islam sudah banyak berinteraksi secara intens dengan Al-Qur’an. Adapun polemik ulama di dalamnya, berpendapat bahwa penafsiran lughawi cenderung memihak pada golongan tertentu. Selain itu, penafsirannya pun tidak kreatif karena seringkali mengulang penafsiran yang ada. Polemik inilah yang kemudian dapat menghilangkan esensi dari penafsiran Al-Qur’an sebagai petunjuk bagi seluruh umat. Pembahasan ini diteliti agar dapat dikaji oleh para pengkaji keilmuan Al-Qur’an, sedikitnya mendapatkan manfaat yang terkandung didalamnya, serta kekurangannya dapat disempurnakan oleh penelitian berikutnya.
Implementasi Stabilitas Sosial Menurut Penganut Agama Buddha, Tao, dan Konghucu di Kota Bandung
Authors: Nurjanah Siti
Published: March 2023

Stabilitas sosial yaitu keseimbangan pada suatu keadaan dimana sedang terjadinya masalah namun tetap pada posisinya dan dapat merubah sesuai dengan keadaan. Durkheim membagi stabilitas sosial ini menjadi empat pola yaitu pola pertama adanya kontrak sosial pada masyarakat eropa tradisional; pola yang kedua mengenai kebahagiaan di dunia pada individu; pola ketiga, dalam bidang politik ketika sistem demokrasi lebih dominan dikuasai oleh penguasa; dan pola keempat yaitu mengenai urusan yang dimiliki individu secara pribadi dengan melepaskan semua pola pikir yang terdapat di masa lalu. Kerangka tersebut dipakai dalam analisis penelitan ini, yaitu mengenai kestabilan pada ketiga agama yaitu Agama Buddha, Konghucu, dan Tao. Analisis kelembagaan pun dimunculkan dalam rangka melihat pola interaksi lembaga keagamaan dengan pemerintah. Tercapainya sebuah kedamaian dan toleransi pada ketiga agama tersebut di Kota Bandung telah memunculkan terjalinnya hubungan yang terus berkembang dan luas dalam peranan masyarakat dan umat lainnya.
Analisis Penafsiran Tokoh Feminis Terhadap Ayat-Ayat Nusyuz dalam Al-Qur’an
Authors: Sidik Azis Abdul , Imaduddin Ihsan
Published: March 2023

Penelitian ini membahas tentang penafsiran nusyuz oleh tokoh feminis dengan metode deskriptif analitik dan berbasis library research, hasil dari penelitian ini adalah bahwa penafsiran dua teks Al-Qur’an tentang penanganan nusyuz yang dilakukan oleh suami dan istri selama ini dipahami secara terpisah. Nusyuz oleh istri ditangani menggunakan tafsiran surat annisa ayat 34 sedangkan nusyuz oleh suami ditangani oleh tafsiran surat Annisa ayat 128. Studi pada beberapa literatur memperlihatkan bahwa perbedaan penanganan ini terkesan lebih berpihak kepada laki-laki, dimana wanita ditempatkan dalam posisi yang lemah dan berada pada pihak yang harus lebih banyak berkorban. Dalam periode awal, penafsiran pernikahan dipahami sebagai akad peralihan kepemilikan (aqd tamlik) lelaki atas wanita. Peralihan kepemilikan wanita dari walinya kepada suami dalam konteks saat ini dapat dimaknai bahwa wanita adalah properti yang bisa dimiliki lelaki. Qiraah mubadalah menawarkan kosep kesetaraan antara suami dan istri di atas lima pilar pernikahan yaitu mitsaqon ghlidzo, zawaj, taradhin, mu’asyarah bil ma’ruf, dan musyawarah. Prinsip kesetaraan yang ditawarkan qiraah mubadalah membawa penelitian ini untuk membaca kembali annisa ayat 34 dan 128 dengan semangat emansipatoris. Hasilnya menunjukan bahwa penanganan nusyuz pada kedua ayat tersebut bersifat komplementer dan berlaku secara bersamaan untuk suami dan istri. Annisa ayat 34 merupakan penangan bertahap atas prilaku nusyuz, sedangkan ayat 128 merupakan petunjuk dalam rangka resolusi konflik dengan renegoisasi atas kesepahaman dan kesepakatan dalam pernikahan.
STRUKTUR KOMUNITAS MANGROVE DI PULAU PEMAGARAN, KEPULAUAN SERIBU, DKI JAKARTA
Authors: Hakim Muhammad Romdonul , Kusdinar Afriana , Kiswandi Malika Felizia , Yusri Safran
Published: March 2023

Pengamatan mangrove di Pulau Pemagaran, Kepulauan Seribu mengambil lokasi stasiun pengamatan di bagian utara, timur, selatan, dan barat Pulau Pemagaran dengan substrat berupa pasir berlumpur. Ekosistem mangrove di Pulau Pemagaran memiliki Indeks Nilai Penting (INP) berkisar dari 32,02 – 300,00. Pada stasiun 1 Rhizophora mucronata menjadi jenis mangrove yang paling dominan untuk stadia pohon dan anakan dengan INP masing-masing 250,00 dan 165,74; sedangkan untuk stadia semai Rhizophora stylosa menjadi jenis mangrove yang paling dominan dengan INP sebesar 81,41. Pada stasiun 2 mangrove jenis Sonneratia alba adalah yang paling dominan untuk stadia pohon dengan INP sebesar 106,09; sedangkan untuk stadia anakan dan semai Rhizophora mucronata menjadi mangrove yang paling dominan dengan INP masing-masing sebesar 174,58 dan 82,89. Pada stasiun 3 hanya terdapat 1 individu mangrove yaitu dalam stadia pohon sehingga Rhizophora stylosa memiliki INP sebesar 300,00. Terakhir, pada stasiun 4 hanya terdapat satu jenis mangrove yaitu Rhizophora stylosa pada stadia anakan dan semai sehingga INPnya sebesar 300,00. Rhizophora stylosa merupakan jenis mangrove yang sebarannya terdapat di seluruh stasiun, sekaligus menandakan merupakan mangrove baru yang sengaja ditanam di Pulau Pemagaran. Pulau Pemagaran memiliki nilai indeks keanekaragaman berkisar antara 0 – 1,30. Hal ini menunjukkan keanekaragaman jenis mangrove yang tumbuh di Pulau Pemagaran tergolong rendah atau bersifat seragam.Observations of mangroves on Pemagaran Island, Seribu Islands took the location of observation stations in the north, east, south, and west of Pemagaran Island with the substrate in the form of muddy sand. The mangrove ecosystem on Pemagaran Island has an Important Value Index (INP) ranging from 32.02 – 300.00. At station 1 Rhizophora mucronata became the most dominant mangrove species for tree and tiller stages with INPs of 250.00 and 165.74, respectively; while for the seedling stage, Rhizophora stylosa became the most dominant mangrove species with an INP of 81.41. At station 2, the Sonneratia alba mangrove species was the most dominant for the tree stage with an INP of 106.09; while for the tiller and seedling stages, Rhizophora mucronata became the most dominant mangrove with INPs of 174.58 and 82.89, respectively. At station 3 there is only 1 individual mangrove, namely in the tree stage so that Rhizophora stylose has an INP of 300.00. Finally, at station 4 there is only one type of mangrove, namely Rhizophora stylosa at the tiller and seedling stages so that the INP is 300.00. Rhizophora stylose is a type of mangrove whose distribution is found in all stations, as well as indicating that it is a new mangrove deliberately planted on Pemagaran Island. Pemagaran Island has a diversity index value ranging from 0 to 1.30. This shows that the diversity of mangrove species growing on Pemagaran Island is low or uniform.
The role of Human Development Index in the epidemiology of asthma in adolescents in Kosovo
Authors: Ahmetaj Luljeta , Martínez-Torres A. Elena , Ahmetaj Ylli , Ismajli Ibadete , Kurhasani Xhevat , Lokaj-Berisha Violeta , Lumezi Besa , Lumezi Leonora , Pajaziti Laura , Shahini Mirsije , Gashi Valbona , Alvarez Luis
Published: March 2023

Background: Very limited information is available on the prevalence and risk factors of asthma in adolescents in Kosovo, and no study has previously addressed the role of Human Development Index (HDI) on asthma in the region. The present study addresses these two issues.Methods: Following the Global Asthma Network (GAN) methodology, a cross-sectional survey, through standardised self-completed questionnaires, was conducted in the following six centres of Kosovo: Ferizaj, Gjakova, Gjilan, Peja, Prishtina and Prizren. Current asthma symptoms (CAS) and severe current asthma symptoms (sCAS) were defined according to the GAN standards. Environmental questionnaire inquired about gender, exercise, screening time, siblings, truck traffic, use of paracetamol, pet ownership, and smoking habits. Height and weight were also measured. Multivariate logistic regression analyses were performed in each centre along with meta-analyses to summarise the overall effects of each factor in the centres as a whole. Meta-regression of the prevalence rates was calculated using HDI as a moderator.Results: Participation rate was high (80.0–99.9%). Prevalence of CAS ranged from 4.6% to 11.3%, and sCAS from 1.7% to 4.5%. Factors associated with CAS were exercise, computer time, paracetamol use and dog ownership. sCAS was associated with paracetamol use and physical exercise. HDI explained 46% and 80% of prevalence variability of CAS and sCAS between centres, respectively.Conclusions: Prevalence of CAS and sCAS in Kosovo varies highly between centres. This variability is explained partly by HDI. Individual risk factors are common, with some determined inother studies conducted in other regions.
ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and inflammation by regulating miR-23a-3p/TLR4 axis
Authors: Yang Xin , Lu Liqun , Wu Chan , Zhang Feng
Published: March 2023

Background: Sepsis is a life-threatening disease with dominant mortality. Its early diagnosis and treatment can improve prognosis and reduce mortality. Long noncoding RNAs (lncRNAs) ATPase plasma membrane Ca2+ transporting 1 antisense RNA 1 (ATP2B1-AS1) is dysregulated and is involved in the progression of various diseases. Nevertheless, the role of ATP2B1-AS1 in sepsis remains unclear.
Methods: A human monocytic cell line, THP-1 cells, was stimulated to induce a model of sepsis in vitro. The levels of ATP2B1-AS1, miR-23a-3p, and TLR4 were assessed by real-time quantitative polymerase chain reaction. The role of ATP2B1-AS1 in cell apoptosis and inflammation was explored by flow cytometry, Western blot analysis and enzyme-linked immunosorbent serologic assay. The binding sites between ATP2B1-AS1 and miR-23a-3p, and between miR-23a-3p and TLR4 were predicted by BiBiServ and the Encyclopedia of RNA Interactomes (ENCORI) online sites, respectively, and confirmed by the luciferase assay.
Results: The level of ATP2B1-AS1 was increased in lipopolysaccharide (LPS)-treated THP-1 cells. LPS increased apoptosis ratio, relative protein expressions of pro-apoptotic factors, and relative messenger RNA (mRNA) level and concentrations of pro-inflammatory cytokines, but decreased the relative expression of anti-apoptosis protein and relative mRNA level and concentrations of anti-inflammatory factor. All these alterations were reversed with transfection of shATP2B1-AS1 into THP-1 cells. Moreover, ATP2B1-AS1 directly bound miR-23a-3p and negatively modulated the level of miR-23a-3p. Meanwhile, TLR4 was directly targeted by miR-23a-3p, and negatively and positively modulated by miR-23a-3p and ATP2B1-AS1, respectively.
Conclusion: ATP2B1-AS1 aggravated apoptosis and inflammation by modulating miR-23a-3p/TLR4 axis in LPS-treated THP-1 cells.
STUDY OF TIME CHARACTERISTICS OF GRAIN RECEIVING FROM AUTO TRANSPORT AT PROCUREMENT ELEVATORS
Authors: Dmytrenkо L. , Sokolovskaya O. , Valevskaya L.
Published: March 2023

At harvesting elevators and grain receiving enterprises, the operation of receiving grain from motor vehicles is the main one. Many elevators of other types also accept grain from motor vehicles due to the fact that it allows to improve the economic performance of the enterprise, and in general, the combination of functions inherent in elevators of different types is a feature of enterprises in the elevator industry of our country. For almost all elevators or grain terminals, the issue of car queues before the entrance is acute. The introduction of various high-performance car unloaders helps to increase the capacity of elevators for unloading grain from cars and road trains of all types. The process of receiving grain from vehicles consists of several operations, and each operation in this chain is important in reducing the time the vehicle stays at the enterprise, and therefore, increasing its throughput. We analyzed the process of unloading cars on U-15URAG-U car unloaders installed at two procurement elevators in the Mykolaiv and Zhytomyr regions. In the course of carrying out this scientific study, we timed the unloading process of 20 single cars (that is, without trailers), which were used to deliver grain to the enterprise. The main stages of unloading cars in the reception facilities of the studied enterprises were highlighted and the average (most reliable), minimum and maximum execution time of each stage was determined. Schedules of the unloading of vehicles with wheat grain at the harvesting elevators, where the research was carried out, were constructed. The results of the timing of the unloading of cars in the receiving device showed that the longest stage is the lifting of the platform of the car loader and the pouring of grain, and the least lasting is the exit of the driver from the cab. The average unloading time was 561.5 seconds for the first enterprise (Mykolaiv Region) and 565 seconds for the second (Zhytomyr Region). It should be noted that the time of raising and lowering the platforms of U15-URAG-U truck unloaders at both considered enterprises corresponds to the passport data, that is, the truck unloaders are not working at maximum efficiency.
GLOBAL FEED PRODUCTION REMAINS STEADY IN 2022
Authors: Https://www.alltech.com/ Alltech
Published: March 2023

Pet feed shows most significant growth while reduction in beef feed production begins to moderateAn assessment of compound feed production and prices was conducted using information gathered by Alltech's global sales team in partnership with local feed associations.The Alltech Agri-Food Outlook also offers a holistic view of the state of the industry, using responses from our corresponding qualitative survey to identify trends and technologies impacting the agri-food industry, highlight growth opportunities and assess expectations for 2023.
Frontiers and Structural Transformations of the Global Pharmaceutical Market
Authors: Starodubov Vladimir  I. , Kobyakova O. S. , Deev Ivan  A. , Kanev Alexander  F. , Kurakova Natalia  G. , Tsvetkova Liliya  A.
Published: March 2023

Background. In order to achieve the technological sovereignty of the Russian Federation, the transformation of existing scientific reserves into in-demand technologies and technologically independent sectors of the economy, special attention is paid to the frontier areas of world science. At the same time, frontiers are understood as thematic areas on the basis of which Russian critical technologies will be developed in the import-saving paradigm. Aims the purpose of the study is to identify the most promising niches of the global pharmaceutical market and research areas focused on their expansion. Methods. Analysis of the volume of RD financing by the worlds leading pharmaceutical companies in the period 20152022, multi-criteria scientometric analysis and thematic mapping of the collection of the most highly cited reviews published in 20202022 and indexed in the Scopus database. Results. The analysis of the volume of RD financing by the worlds leading pharmaceutical companies in the period 20152022, and their average annual growth rates, was carried out. It is shown that with an annual increase in the corporate RD budget of 2.8%, by 2022 the total RD expenditures of key players in the global pharmaceutical market reached $182 billion per year. At the same time, 60% of these funds ($109.4 billion) fell in 2022 to the top 20 global pharmaceutical companies investing in the development of new medicines. For comparison, the internal costs of research and development of the Russian Federation are given, which, taking into account the GDP deflator as of 08.04.2022, are estimated at $48 billion, of which the amount of budget funding provided in 2023 for the priority direction of the Strategy of Scientific and Technological Development of the Russian Federation Transition to personalized medicine, high-tech healthcare and technologies health savings, including through the rational use of medicines (primarily antibacterial), will amount to 39.5 billion rubles. Given the relatively low level of funding for domestic research and development of new medicines (compared to the budgets for RD of pharmaceutical companies in the world), it seemed important to identify the most promising niches of the global pharmaceutical market and research areas focused on their expansion. Conclusion. As a result of multi-criteria scientometric analysis and thematic mapping of the collection of the most highly cited reviews published in 20202022 and indexed in the Scopus database, 10 frontier research areas have been identified that have the potential to transform the structure of the global pharmaceutical market until 2030.
From Molecule to Drug. Pharmaceutical Logistics Approach
Authors: Petrov Vladimir I. , Tyurenkov Ivan N. , Kurkin Denis V.
Published: March 2023

The development of original drugs is a complex, time-consuming, labor-intensive, costly, and risky process. The pharmaceutical industry is a critically important area of technological sovereignty of the country. Effective functioning of the drug supply system is impossible without original drug development process, which provide the foundation for progressive evolution of a number of branches of the socio-economic sector of the countrys economy. Domestic pharmacology faces several unresolved problems, many of which must be viewed through the prism of pharmacological disciplines, primarily theoretical and clinical pharmacology, and considering the evolution of approaches used in them. Pharmacology is a system of thought for pharmacologists and experts in drug development, aiming not only to improve the quality and quantity of drugs created, but also to accelerate this process. This article describes the essence of the pharmacological approach, briefly describing the main stages of the development of an original drug from the idea to research conducted, after the widespread introduction of the drug into clinical practice. At the end of the article the authors presented the successful experience of pharmacological approach application by pharmacologists of Volgograd State Medical University on the example of the development of an original drug for the treatment of diabetes mellitus and its complications.
Antiaging Klotho Protein as a Prospective Novel Tumor Suppressor
Authors: Nesterova Kristina I. , Glinka Yelena Yu. , Perfilova Valentina N. , Nesterova Alla A. , Kaplanov Kamil D.
Published: March 2023

-Isomer of Klotho Protein has been actively studied over the past 20 years. It has been found that -Klotho is closely associated with aging and has anti-aging properties. Besides, it is involved in development of malignant tumor diseases. Its universal influence on many biological mechanisms leading to hyperplastic changes in cells and tissues has been proven experimentally. Recent studies demonstrated inhibitory effect of -Klotho on the classical carcinogenic pathways such as insulin-like growth factor 1 (IGF1), fibroblast growth factor (FGFs), transforming growth factor 1 (TGFb1), Wnt, P53/p21, oxidative stress response pathways. Impeding effect of -Klotho protein on the development of such types of malignant tumors as breast, pancreatic, lung, stomach, hepatocarcinoma, and others is proven in a number of cases. This review describes the role of -Klotho in oncogenesis, its involvement and influence on the main signaling pathways known for their role in the development of malignant tumors, and the possibility of regulating its expression.
Immune Landscape Characteristics in Endometriosis
Authors: Patsap Olga I. , Khabarova Marina B. , Buyanova Anastasiia A. , Mikhalev Sergey A. , Atyakshin Dmitriy A. , Babkina Alexandra  V. , Mikhaleva Liudmila M.
Published: March 2023

This review is devoted to endometriosis-associated immune cells and immune molecules, analysis of various databases, new insights, theories, biomarkers, reviews of research in this area. To date, many attempts have been made to establish a certain role of immune cells and the microenvironment in the development of endometriosis. Nevertheless, despite intensive studies of endometriosis, the role of inflammatory cells and molecules has not yet been fully studied. As we know, the pathobiology of endometriosis is not fully understood, and its progression is associated with a local and systemic inflammatory reaction. It is important to clarify the role of the immune system to better understand its significance in the pathogenesis of endometriosis, especially in the case of atypical and endometriosis-associated ovarian tumors. The above requires further study of this problem in order to optimize the pathogenetically justified modern therapy of endometriosis.
MRI for Quantitative Determination of Iron in the Liver and Heart in Patients with Primary and Secondary Hemochromatoses in Association with Serrum Ferritin: Single-Stage Observational Study
Authors: Titova Anna M. , Fokin Vladimir A. , Trufanov Gennadii E. , Shalygina Ksenia S. , Tsvetkova Nadezhda V.
Published: March 2023

Background. An extremely small number of studies have been devoted to the study of differences in LIC (liver iron concentration) and MIC (myocardium iron concentration) indicators, as well as their correlation with each other and with ferritin levels in patients with various nosological forms. Aims to study the relationship of ferritin, LIC and MIC levels in patients with various causes of hemochromatosis (hereditary hemochromatosis (HH), aplastic anemia (AA), primary myelofibrosis (PMF), thalassemia (TL), myelodysplastic syndrome (MDS)). Methods. The design of the study is a singlestage observational one. The study included 91 patients with primary hemochromatosis and secondary transfusion-dependent hemochromatosis receiving regular blood transfusion and iron chelate therapy from 2015 to 2018. The studies were carried out on 1.5 T MR-scanner Magnetom Espree (Siemens, Germany), and myocardial iron concentration (MIC) was calculated using the formula MIC = 45 (T2*) 1.22. Liver iron concentration (LIC) was calculated using the formula LIC = 0.03 R2* + 0.74. The ferritin level was determined by enzyme immunoassay. Statistical processing of the results obtained was carried out using the SPSS software package. Results. Connections between LIC and ferritin (r = 0.867; p 0.001), MIC and ferritin (r = 0.759; p = 0.004) and LIC and MIC (r = 0.737; p = 0.006) were found in patients with primary hemochromatosis, while in patients with secondary hemochromatosis significant correlations were found only between LIC and MIC (r = 0.503; p 0.001), while the relationship was average. Links between LIC and ferritin were found in patients with AA (r = 0.656; p = 0.040), an average relationship, in patients with TL (r = 0.714; p = 0.020), an average relationship. The relationship between MIC and ferritin was revealed in patients with AA (r = 0.703; p = 0.050), an average relationship, in patients with TL (r = 0.757; p = 0.018), an average relationship. At the same time, in patients with MDS and PMF in this study, there was no association between ferritin and LIC, ferritin and MIC. Conclusions. In patients with hereditary hemochromatosis, LIC and MIC are associated with ferritin, and MIC is also associated with LIC (medium bond). In patients with iron overload due to thalassemia, an average correlation between LIC and ferritin, MIC and ferritin was revealed. In patients with iron overload due to aplastic anemia, an average correlation between LIC and ferritin, MIC and ferritin was revealed.
To the 70th Anniversary of Academician of the Russian Academy of Sciences Evgeny Lhamatsyrenovich Choynzonov
Authors: Reshetov Igor V. , Sergeeva Natalia V. , Serikov Alexei A.
Published: March 2023

On December 14, 2022, Yevgeny Lhamatsyrenovich Choinzonov, Doctor of Medical Sciences, Professor, Academician of the Russian Academy of Sciences, Honored Scientist of the Russian Federation, Director of the Research Institute of Oncology of the Tomsk National Research Medical Center of the Russian Academy of Sciences, Head of the Department of Oncology of the Siberian State Medical University (Tomsk), turned 70 years old.
Teaching Forensic Social Work: Innovative Education through Service-Learning
Authors: Eaton-Stull Yvonne , Potts Noelle , Pridgen Serena , Farren Doris
Published: March 2023

The high impact, experiential education of service-learning was utilized in a Forensic Social Work class to enhance students’ social work skills.  Students and faculty, along with another community partner provided animal-assisted grief support groups to individuals who were incarcerated.  Two support groups were provided to individuals who suffered a recent or unresolved loss, one with women and one with men.  Social work skills of empathy, professional boundaries, social justice, group facilitation, and applying theory to practice were greatly enhanced through this service-learning, high impact practice.  The added value of therapy dogs in enhancing the therapeutic process was also noted.