bluuebunny/crossref_metadata_2025 huggingface dataset:
How to Promote Skin Repair? In-Depth Look at Pharmaceutical and Cosmetic Strategies
Authors: Torres Ana , Rego Liliana , Martins Márcia S. , Ferreira Marta S. , Cruz Maria T. , Sousa Emília , Almeida Isabel F.
Published: April 2023

Skin repair encompasses epidermal barrier repair and wound healing which involves multiple cellular and molecular stages. Therefore, many skin repair strategies have been proposed. In order to characterize the usage frequency of skin repair ingredients in cosmetics, medicines, and medical devices, commercialized in Portuguese pharmacies and parapharmacies, a comprehensive analysis of the products’ composition was performed. A total of 120 cosmetic products, collected from national pharmacies online platforms, 21 topical medicines, and 46 medical devices, collected from INFARMED database, were included in the study, revealing the top 10 most used skin repair ingredients in these categories. A critical review regarding the effectiveness of the top ingredients was performed and an in-depth analysis focused on the top three skin repair ingredients pursued. Results demonstrated that top three most used cosmetic ingredients were metal salts and oxides (78.3%), vitamin E and its derivatives (54.2%), and Centella asiatica (L.) Urb. extract and actives (35.8%). Regarding medicines, metal salts and oxides were also the most used (47.4%) followed by vitamin B5 and derivatives (23.8%), and vitamin A and derivatives (26.3%). Silicones and derivatives were the most common skin repair ingredients in medical devices (33%), followed by petrolatum and derivatives (22%) and alginate (15%). This work provides an overview of the most used skin repair ingredients, highlighting their different mechanisms of action, aiming to provide an up-to-date tool to support health professionals’ decisions.
Synergistic Encapsulation of Paclitaxel and Sorafenib by Methoxy Poly(Ethylene Glycol)-b-Poly(Caprolactone) Polymeric Micelles for Ovarian Cancer Therapy
Authors: Jin Chae Eun , Yoon Moon Sup , Jo Min Jeong , Kim Seo Yeon , Lee Jae Min , Kang Su Jeong , Park Chun-Woong , Kim Jin-Seok , Shin Dae Hwan
Published: April 2023

Ovarian cancer has a high mortality rate due to difficult detection at an early stage. It is necessary to develop a novel anticancer treatment that demonstrates improved efficacy while reducing toxicity. Here, using the freeze-drying method, micelles encapsulating paclitaxel (PTX) and sorafenib (SRF) with various polymers were prepared, and the optimal polymer (mPEG-b-PCL) was selected by measuring drug loading (%), encapsulation efficiency (%), particle size, polydispersity index, and zeta potential. The final formulation was selected based on a molar ratio (PTX:SRF = 1:2.3) with synergistic effects on two ovarian cancer cell lines (SKOV3-red-fluc, HeyA8). In the in vitro release assay, PTX/SRF micelles showed a slower release than PTX and SRF single micelles. In pharmacokinetic evaluation, PTX/SRF micelles showed improved bioavailability compared to PTX/SRF solution. In in vivo toxicity assays, no significant differences were observed in body weight between the micellar formulation and the control group. The anticancer effect of PTX/SRF combination therapy was improved compared to the use of a single drug. In the xenografted BALB/c mouse model, the tumor growth inhibition rate of PTX/SRF micelles was 90.44%. Accordingly, PTX/SRF micelles showed improved anticancer effects compared to single-drug therapy in ovarian cancer (SKOV3-red-fluc).
Nanomaterial-Based Antivascular Therapy in the Multimodal Treatment of Cancer
Authors: Ma Xiaocong , Fang Weimin , Wang Duo , Shao Ni , Chen Jifeng , Nie Tianqi , Huang Cuiqing , Huang Yanyu , Luo Liangping , Xiao Zeyu
Published: April 2023

Abnormal tumor vasculature and a hypoxic tumor microenvironment (TME) limit the effectiveness of conventional cancer treatment. Recent studies have shown that antivascular strategies that focus on antagonizing the hypoxic TME and promoting vessel normalization effectively synergize to increase the antitumor efficacy of conventional therapeutic regimens. By integrating multiple therapeutic agents, well-designed nanomaterials exhibit great advantages in achieving higher drug delivery efficiency and can be used as multimodal therapy with reduced systemic toxicity. In this review, strategies for the nanomaterial-based administration of antivascular therapy combined with other common tumor treatments, including immunotherapy, chemotherapy, phototherapy, radiotherapy, and interventional therapy, are summarized. In particular, the administration of intravascular therapy and other therapies with the use of versatile nanodrugs is also described. This review provides a reference for the development of multifunctional nanotheranostic platforms for effective antivascular therapy in combined anticancer treatments.
Mixed Edge Activators in Ibuprofen-Loaded Transfersomes: An Innovative Optimization Strategy Using Box–Behnken Factorial Design
Authors: Vieira João , Castelo Jéssica , Martins Marta , Saraiva Nuno , Rosado Catarina , Pereira-Leite Catarina
Published: April 2023

Transfersomes have been highlighted as an interesting nanotechnology-based approach to facilitate the skin delivery of bioactive compounds. Nevertheless, the properties of these nanosystems still need to be improved to enable knowledge transfer to the pharmaceutical industry and the development of more efficacious topical medicines. Quality-by-design strategies, such as Box–Behnken factorial design (BBD), are in line with the current need to use sustainable processes to develop new formulations. Thus, this work aimed at optimizing the physicochemical properties of transfersomes for cutaneous applications, by applying a BBD strategy to incorporate mixed edge activators with opposing hydrophilic–lipophilic balance (HLB). Tween® 80 and Span® 80 were used as edge activators and ibuprofen sodium salt (IBU) was selected as the model drug. After the initial screening of the IBU solubility in aqueous media, a BBD protocol was implemented, and the optimized formulation displayed appropriate physicochemical properties for skin delivery. By comparing the optimized transfersomes to equivalent liposomes, the incorporation of mixed edge activators was found to be beneficial to upgrade the storage stability of the nanosystems. Furthermore, their cytocompatibility was shown by cell viability studies using 3D HaCaT cultures. Altogether, the data herein bode well for future advances in the use of mixed edge activators in transfersomes for the management of skin conditions.
Dispersion Engineering of Waveguide Microresonators by the Design of Atomic Layer Deposition
Authors: Wang Pei-Hsun , Hou Nien-Lin , Ho Kung-Lin
Published: April 2023

In this work, we demonstrate dispersion engineering of silicon nitride waveguide resonators with atomic layer deposition (ALD). We conducted theoretical and experimental analyses on the waveguide dispersion with air cladding, hafnium oxide (HfO2) cladding, and aluminum oxide (Al2O3) cladding. By employing ALD HfO2 as the cladding layer, the dispersion of waveguide can be tuned to a finer degree in the normal regime at a wavelength of 1550 nm. On the other hand, using ALD Al2O3 cladding provides the waveguide dispersion that spans regimes in normal, near-zero, and anomalous dispersion.
Reduction in the Use of Some Herbicides Favors Nitrogen Fixation Efficiency in Phaseolus vulgaris and Medicago sativa
Authors: Paniagua-López Mario , Jiménez-Pelayo César , Gómez-Fernández Germán Orlando , Herrera-Cervera José Antonio , López-Gómez Miguel
Published: April 2023

In recent decades, the quality of agricultural soils has been seriously affected by the excessive application of pesticides, with herbicides being one of the most abundant. Continuous use of herbicides alters the soil microbial community and beneficial interactions between plants and bacteria such as legume-rhizobia spp. symbiosis, causing a decrease in the biological nitrogen fixation, which is essential for soil fertility. Therefore, the aim of this work was to study the effect of two commonly used herbicides (pendimethalin and clethodim) on the legume-rhizobia spp. symbiosis to improve the effectiveness of this process. Phaseolus vulgaris plants grown in pots with a mixture of soil:perlite (3:1 v/v), showed a 44% inhibition of nitrogen fixation rate with pendimethalin. However, clethodim, specifically used against monocots, did not induce significant differences. Additionally, we analyzed the effect of herbicides on root exudate composition, detecting alterations that might be interfering with the symbiosis establishment. In order to assess the effect of the herbicides at the early nodulation steps, nodulation kinetics in Medicago sativa plants inoculated with Sinorhizobium meliloti were performed. Clethodim caused a 30% reduction in nodulation while pendimethalin totally inhibited nodulation, producing a reduction in bacterial growth and motility as well. In conclusion, pendimethalin and clethodim application reduced the capacity of Phaseolus vulgaris and Medicago sativa to fix nitrogen by inhibiting root growth and modifying root exudate composition as well as bacterial fitness. Thus, a reduction in the use of these herbicides in these crops should be addressed to favor a state of natural fertilization of the soil through greater efficiency of leguminous crops.
Experimental Hardware-in-the-Loop Centrifugal Pump Simulator for Laboratory Purposes
Authors: Gevorkov Levon , Domínguez-García José Luis
Published: April 2023

A hardware-in-the-loop (HIL) experimental test-bench is suggested for a rotodynamic pump in this paper. The HIL simulator is composed of two separate modules and two variable-speed drive (VSD) systems that are connected with the help of a programmable logical controller (PLC) and a process field bus unit. One of the fundamental components of the suggested simulation approach is the mathematical representation of a rotodynamic pump system embedded into HIL. A number of tests were conducted in order to study the suggested simulation approach. The experiments demonstrated the developed system’s adaptability and precision in replicating the behavior of the rotodynamic pump in various operation modes. A special user interface for the HIL simulation allows for changing the types of preloaded pump characteristics, reading the output data, and controlling operational parameters. The obtained simulation results showed that the proposed approach can be suitable for research purposes.
Frequent Alarm Pattern Mining of Industrial Alarm Flood Sequences by an Improved PrefixSpan Algorithm
Authors: Yang Songbai , Zhang Tianxing , Zhai Yingchun , Wang Kaifa , Zhao Guoxi , Tu Yuanfei , Cheng Li
Published: April 2023

Alarm systems are essential to the process safety and efficiency of complex industrial facilities. However, with the increasing size of plants and the growing complexity of industrial processes, alarm flooding is becoming a serious problem and posing challenges to alarm systems. Extracting alarm patterns from an alarm flood database can assist with an alarm root cause analysis, decision support, and the configuration of an alarm suppression model. However, due to the large size of the alarm database and the problem of sequence ambiguity in the alarm sequence, existing algorithms suffer from excessive computational overhead, incomplete alarm patterns, and redundant outputs. In order to solve these problems, we propose an alarm pattern extraction method based on the improved PrefixSpan algorithm. Firstly, a priority-based pre-matching strategy is proposed to cluster similar sequences in advance. Secondly, we improved PrefixSpan by considering timestamps to tolerate short-term order ambiguity in alarm flood sequences. Thirdly, an alarm pattern compression method is proposed for the further distillation of pattern information in order to output representative alarm patterns. Finally, we evaluated the effectiveness and applicability of the proposed method by using an alarm flood database from a real diesel hydrogenation unit.
Weather Radar Super-Resolution Reconstruction Based on Residual Attention Back-Projection Network
Authors: Yu Qiu , Zhu Ming , Zeng Qiangyu , Wang Hao , Chen Qingqing , Fu Xiangyu , Qing Zhipeng
Published: April 2023

Convolutional neural networks (CNNs) have been utilized extensively to improve the resolution of weather radar. Most existing CNN-based super-resolution algorithms using PPI (Plan position indicator, which provides a maplike presentation in polar coordinates of range and angle) images plotted by radar data lead to the loss of some valid information by using image processing methods for super-resolution reconstruction. To solve this problem, a weather radar that echoes the super-resolution reconstruction algorithm—based on residual attention back-projection network (RABPN)—is proposed to improve the the radar base data resolution. RABPN consists of multiple Residual Attention Groups (RAGs) connected with long skip connections to form a deep network; each RAG is composed of some residual attention blocks (RABs) connected with short skip connections. The residual attention block mined the mutual relationship between low-resolution radar echoes and high-resolution radar echoes by adding a channel attention mechanism to the deep back-projection network (DBPN). Experimental results demonstrate that RABPN outperforms the algorithms compared in this paper in visual evaluation aspects and quantitative analysis, allowing a more refined radar echo structure, especially in terms of echo details and edge structure features.
High-Resolution Resistivity Imaging of a Transversely Uneven Gas Hydrate Reservoir: A Case in the Qiongdongnan Basin, South China Sea
Authors: Liu Chenggong , Jing Jianen , Zhao Qingxian , Luo Xianhu , Chen Kai , Wang Meng , Deng Ming
Published: April 2023

Marine controlled-source electromagnetics (MCSEM) is an effective method to map the spatial distribution of gas hydrate and calculate gas hydrate saturation. An MCSEM survey is conducted in the Lingnan low uplift (LNLU), Qiongdongnan Basin (QDNB), South China Sea (SCS), and then the measured data are processed to obtain the geoelectric structure. The estimated gas hydrate stability zone (GHSZ) ranges from 0 to 320 mbsf, and shallow high-conductive sediments serving as gas hydrate caps are at depths ranging from 0 to 100 mbsf (meters below the seafloor). The 2D resistivity model reveals multiple high-resistivity bodies at depths ranging from 100 to 320 mbsf, and BSRs are at depths of 240 mbsf to 280 mbsf, indicating a transversely uneven gas hydrate reservoir in the study area. Moreover, two high-resistivity bodies are detected beneath the GHSZ, implying the presence of potential gas transport pathways. The gas hydrate saturation with a variation of 0–68.4% is calculated using the MCSEM resistivity and Archie’s law. According to the resistivity model and geological data, the transversely uneven gas hydrate reservoir may be associated with multiple gas sources, including shallow biogenic gas and deep pyrolytic gas. The shallow biogenic gas is transported to the GHSZ via short-distance migration and free diffusion, and the deep pyrolytic gas is transported to the GHSZ via two microcracks. In addition, this case emphasizes that the dynamic accumulation of gas hydrate is an important factor causing reservoir heterogeneity.
Combined Improved CEEMDAN and Wavelet Transform Sea Wave Interference Suppression
Authors: Luo Jianping , Liang Xingdong , Guo Qichang , Zhang Liqi , Bu Xiangxi
Published: April 2023

Cross water–air interface acoustic and electromagnetic integrated communication (AEIC) technology refers to an underwater speaker that excites the water surface micro-amplitude wave (WSAW) on the water’s surface, and millimeter wave radar detects the vibrations of the WSAW to realize the transmission of information. The research on cross-media communication meets many challenges due to the large amplitude of the water surface disturbance and the small amplitude of the WSAW. In this paper, a novel sea wave interference suppression method based on improved complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN) and wavelet transform (WT) is presented. This method divides the phase change into different intrinsic mode functions (IMFs) and obtains a reconstructed scale of the WSAW signal through wavelet decomposition and correlation procession to separate the WSAW signal and the sea wave interference. It is proved to be better than the reference filtering method by experiment. By using this novel method, the bit error rate (BER) of the communication system can be reduced effectively.
Appraisal of Ancient Quarries and WWII Air Raids as Factors of Subsidence in Rome: A Geomatic Approach
Authors: Celauro Angela , Palenzuela Baena José Antonio , Moriero Ilaria , Maass Alexander , Guerrero Tello José Francisco , D’Aranno Peppe Junior Valentino , Marsella Maria
Published: April 2023

Ancient mining and quarrying activities left anthropogenic geomorphologies that have shaped the natural landscape and affected environmental equilibria. The artificial structures and their related effects on the surrounding environment are analyzed here to characterize the quarrying landscape in the southeast area of Rome in terms of its dimensions, typology, state of preservation and interface with the urban environment. The increased occurrence of sinkhole events in urban areas has already been scientifically correlated to ancient cavities under increasing urban pressure. In this scenario, additional interacting anthropogenic factors, such as the aerial bombardments perpetrated during the Second World War, are considered here. These three factors have been investigated by employing a combined geomatic methodology. Information on air raids has been organized in vector archives. A dataset of historical aerial photographs has been processed into Digital Surface Models and orthomosaics to reconstruct the quarry landscape and its evolution, identify typologies of exploitation and forms of collapse and corroborate the discussion concerning the induced historical and recent subsidence phenomena, comparing these outputs with photogrammetric products obtained from recent satellite data. Geological and urbanistic characterization of the study area allowed a better connection between these historical and environmental factors. In light of the information gathered so far, SAR interferometric products allowed a preliminary interpretation of ground instabilities surrounding historical quarries, air raids and recent subsidence events. Various sub-areas of the AOI where the presence of the considered factors also corresponds to areas in slight subsidence in the SAR velocity maps have been highlighted. Bivariate hotspot analysis allowed substantiating the hypothesis of a spatial correlation between these multiple aspects.
Validation of EMI-2 Radiometric Performance with TROPOMI over Dome C Site in Antarctica
Authors: Su Jingming , Si Fuqi , Zhao Minjie , Zhou Haijin , Hong Yan
Published: April 2023

(1) The Environmental Trace Gases Monitoring Instrument-2(EMI-2) is a high-quality spaceborne imaging spectrometer that launched in September 2021. To evaluate its radiometric calibration performance in-flight, the UV2 and VIS1 bands of EMI-2 were cross-calibrated by the corresponding bands (band3 and band4) of TROPOMI over the pseudo-invariant calibration site Dome C. (2) After angle limitation and cloud filtering of the Earth radiance data measured by EMI-2 and TROPOMI over Dome C, the top of atmosphere (TOA) reflectance time series were calculated. The spectral adjustment factors (SAF) were derived from the solar spectrum measured by the sensor to minimize the uncertainties caused by the different spectral response functions (SRF) of sensors. In addition, a correction method based on the radiative transfer model (RTM) SCIATRAN was used to suppress unaccounted angular dependence of atmospheric scattering. The radiation performance of EMI-2 is evaluated using the TOA reflectance ratio of EMI-2 and TROPOMI, combining the SAF correction and RTM-based correction methods. (3) It was shown that the time series trending of the TOA reflectance ratio between EMI-2 measurements and TROPOMI demonstrate flat characteristics and strong correlation. The mean reflectance ratios range from 0.998 to 1.09. The standard deviation of the reflection ratio is less than 3%. For 328 nm, 335 nm, 340 nm, 460 nm, and 490 nm, the mean values are close to one, and the relative radiometric bias estimated through EMI-2 and TROPOMI intercalibration is less than 3%, and for other wavelengths, the biases are less than 6%, except for 416 nm, which behaves higher than 7%. The cross-calibration results show that the radiometric calibration of EMI-2 is within the relative accuracy requirement.
Transition to Distance Learning: Student Experience and Communication during the COVID-19 Pandemic in the United Arab Emirates
Authors: Abdellatif Soumaya , Shomotova Aizhan , Trabelsi Safouane , Husain Salwa , Alsalhi Najeh , Eltahir Mohamed
Published: April 2023

The COVID-19 pandemic in 2020 prompted higher education institutions in the United Arab Emirates (UAE) to switch to online learning for the safety of their citizens. The main purpose of this study is to determine the relationship between four indicators of digital learning experience and the intensity of student socio-pedagogical communication after the transition to distance learning. The data were collected from Ajman University, a private university in the UAE, during the spring of 2020. The sample consisted of 381 students who were surveyed using an online survey tool or email. First, this study found that the majority of students had access to digital tools and the Internet; however, a small number struggled with weak and unreliable Internet connection. Most students had a moderate to high ability to use digital technology, but some encountered difficulties and required assistance. Most students utilised digital communication tools for over five hours daily. The study also found a general lack of digital competency among students and difficulties in using digital tools for remote learning, highlighting the importance of investing in the development of digital skills. The study also found an intensification of social relationships and an increase in communication frequency between students and instructors; however, inadequate instructor–student communication remained a challenge. Finally, the multiple linear regression model showed that indicators such as the communication dimension of the lessons and the participatory nature of the courses positively impacted the intensity of student communication after the transition to distance learning.
Toward Practical Integration of Omic and Imaging Data in Co-Clinical Trials
Authors: Alkim Emel , Dowst Heidi , DiCarlo Julie , Dobrolecki Lacey , Hernández-Herrera Anadulce , Hormuth David , Liao Yuxing , McOwiti Apollo , Pautler Robia , Rimawi Mothaffar , Roark Ashley , Srinivasan Ramakrishnan , Virostko Jack , Zhang Bing , Zheng Fei , Rubin Daniel , Yankeelov Thomas , Lewis Michael
Published: April 2023

Co-clinical trials are the concurrent or sequential evaluation of therapeutics in both patients clinically and patient-derived xenografts (PDX) pre-clinically, in a manner designed to match the pharmacokinetics and pharmacodynamics of the agent(s) used. The primary goal is to determine the degree to which PDX cohort responses recapitulate patient cohort responses at the phenotypic and molecular levels, such that pre-clinical and clinical trials can inform one another. A major issue is how to manage, integrate, and analyze the abundance of data generated across both spatial and temporal scales, as well as across species. To address this issue, we are developing MIRACCL (molecular and imaging response analysis of co-clinical trials), a web-based analytical tool. For prototyping, we simulated data for a co-clinical trial in “triple-negative” breast cancer (TNBC) by pairing pre- (T0) and on-treatment (T1) magnetic resonance imaging (MRI) from the I-SPY2 trial, as well as PDX-based T0 and T1 MRI. Baseline (T0) and on-treatment (T1) RNA expression data were also simulated for TNBC and PDX. Image features derived from both datasets were cross-referenced to omic data to evaluate MIRACCL functionality for correlating and displaying MRI-based changes in tumor size, vascularity, and cellularity with changes in mRNA expression as a function of treatment.
Quantitative Analysis of the Clinical Reasons Influencing the Frequency of Pediatric Head CT Examinations: A Single-Center Observation Study
Authors: Yoshitake Takayasu , Miyazaki Osamu , Kitamura Masayuki , Ono Koji , Kai Michiaki
Published: April 2023

Epidemiological studies on radiation exposure from pediatric CT scans have attracted attention in terms of radiological protection. These studies have not taken into account the reasons why CT examinations were performed. It is presumed that there are clinical reasons that justify more frequent CT examinations in children. The purpose of this study was to characterize the clinical reasons why relatively high numbers of head CT examinations (NHCT) are frequently performed and to conduct a statistical analysis to determine the factors governing the NHCT. Patient information, the date of examination, and medical conditions for examination data stored on the radiology information system were used to investigate the reasons for undergoing CT examinations. The target facility was National Children’s Hospital; data were obtained from March 2002 to April 2017, and the age of the study population was less than 16 years old. Quantitative analysis of the factors associated with frequent examinations was conducted by Poisson regression analysis. Among all patients who had a CT scan, 76.6% had head CT examinations, and 43.4% of children were under 1 year old at the time of the initial examination. There were marked differences in the number of examinations depending on the disease. The average NHCT was higher for children younger than 5 days of age. Among children less than 1 year of age with surgery, there was a marked difference between hydrocephalus, with a mean = 15.5 (95% CI 14.3,16.8), and trauma, with a mean = 8.3 (95% CI 7.2,9.4). In conclusion, this study revealed that NHCT was significantly higher in children who had undergone surgery than in those who had not been to the hospital. The clinical reasons behind patients with higher NHCT should be considered in investigating a causal relationship between CT exposure and brain tumors.
Pratique d’allaitement des enfants du Moyen Age à l’époque contemporaine
Authors: Le Luyer Mathilde , Le Luyer Bernard
Published: April 2023

De l’antiquité au milieu du XVIIIe siècle, l’allaitement artificiel comme nous l’entendons, c’est-à-dire dès la naissance et au moyen d’un lait animal, a été rarement employé. Quand les mères ne peuvent allaiter, régnent les nourrices sur place dans les familles riches et bourgeoises, sur lieu pour les gens de conditions plus modestes. Exceptionnellement sont notés dans la mythologie ou la littérature le récit d’allaitement directement au pis de l’animal. Le lait rentre dans la composition des bouillies : les textes, les inventaires, l’iconographie attestent de l’existence de Pailete pour faire le papin (la bouillie). Au milieu du XVIIIe siècle, la composition du lait animal et du lait de femme commence a être connue. La mortalité effrayante des enfants assistés placés, en nourrice entraîne les hospices à proposer les premières expériences scientifiques d’allaitement artificiel. Toutes seront des échecs. La situation restera voisine pendant un siècle. La hantise de la dépopulation du fait de l’hécatombe des nourrissons placés va conduire d’abord les médecins, puis les politiques à envisager, d’une part à mieux contrôler l’activité des nourrices, d’autre part à rendre l’allaitement artificiel plus sur.
Alternative ways of organizing distance practical classes for future music art teachers
Authors: Yalovskyi Pavlo , Lotsman Ruslana , Yurieva Kateryna , Parfentieva Iryna , Sokolova Alla
Published: April 2023

The aim of this research was to find and study the effectiveness of alternative ways of organizing practical classes in Musical Art for Pedagogy students in the context of distance learning. The research involved semi-structured interviews with teachers and student surveys using a close-ended questionnaire. The content analysis of the answers revealed the main difficulties that the teachers had to deal with when organizing distance practical classes in Musical Art. It also enabled finding optimal ways to eliminate them. Their high efficiency was verified by conducting a pedagogical experiment. It was established that traditional methods of education are impossible during distance learning. They need to be replaced with new ones that are effective in technology-mediated learning. It was found that music teachers used special software, digital musical instruments as an alternative to traditional ones. Teachers also recorded video instructions and video lessons, and students recorded video reports on the work done.

Teachers began to use new teaching methods. Distance learning yielded higher learning outcomes than the traditional one, as technologies are interesting to students and contribute to their motivation and engagement. This article was reduced to the study of the peculiarities of the organization of distance learning of students — future teachers of Musical Art. Further research should be aimed at identifying ways of organizing Music Art education in general secondary educational institutions.
Digital transformations in culture and art: new opportunities and challenges
Authors: Bannikova Kateryna , Fryz Petro , Voronova Nadiia , Voronova Nadiia , Bondarenko Andrii , Bilozub Liudmyla
Published: April 2023

Digitalization covers all areas of social activity. For a long time, cultural and artistic life has been incorporating practical elements of the digital world into its arsenal, while traditionally leaving its creative components unchanged. Technologization, informatization, and digitalization have been used at the stage of production or broadcasting of cultural and artistic content (digital culture, cultural technologies) since their introduction. However, the digital world is gradually beginning to claim the role of a direct creator of cultural elements. Such digital transformations in culture have become a relevant subject of research in the innovation cluster of this sphere of human activity. The purpose of the article is to search for new principles of the process of digitalization of the cultural and artistic cluster in the current conditions of development of the socio-cultural space. It is proposed to find the principles by which the digitalization of culture and art is implemented in two key dimensions: creative and organizational. These principles focus on the flexibility, dynamism and synergy of the cultural and artistic space in the context of digitalization. The research methodology is based on general scientific and cultural methods, as well as synergistic methodological principles. The results of the study indicate that cultural and artistic development in the digital environment is gaining qualitatively new opportunities in the technical, organizational, information, communication, and logistical aspects while demonstrating the potential ability to be realized in the creative segment. Thus, digitalization as a powerful global trend in the development of society shapes innovative trends in the cultural and artistic sphere. The author traces the prospects for synergy of the digital segment in the cultural environment with the actualization of innovative principles.
ARTIFICIAL INTELEGENCE DALAM SISTEM INFORMASI MANAJEMEN DAN KINERJA BERKELANJUTAN
Authors: Riswanto Ari , Rachmadi R. Edy
Published: April 2023

The purpose of this study is to determine the extent to which Artificial Intelligence (AI) variables can moderate the influence between Management Information Systems and Sustainable Performance in Small and Medium Enterprises (SMEs) in West Java - Indonesia. The approach using quantitative descriptive methods through simple linear regression analysis with SPSS was used in this study while for analysis using Structural Equation Modeling (SEM) with Coefficient Product Analysis Strategy: Simple Moderation Model, with a sample of 209 respondents, namely SMEs in West Java Province, Indonesia. The results of the study show that the variable Artificial Intelligence can moderate the influence between Management Information Systems and Sustainable Performance in Small and Medium Enterprises (SMEs) in West Java - Indonesia. In addition, the Management Information System has a positive effect on sustainable performance. The implication of the results of this study is that the performance of SMEs can be improved by increasing the involvement of SMEs in managing their accounting information systems. The value of novelty in this study is that this study uses Artificial Intelligence variables that no one has conducted the same research, besides that IA is used to measure the extent of involvement in the influence of Management Information Systems and Sustainable Performance in small and medium enterprises (SMEs). Further researchers can carry out further research by developing the use of other variables in larger and wider business entities and industries as research samples.

Key words: Artificial Intelligence (AI), Management Information Systems, Sustainable Performance, SMEs.
Some Subclasses of q-Analytic Starlike Functions
Authors: Yalçın Sibel , Bayram Hasan
Published: April 2023

We define two new subclasses, $\mathcal{S}_{q}^{\ast }(\alpha )$ and $\mathcal{TS}_{q}^{\ast }(\alpha )$, of analytic univalent functions. We obtain a sufficient condition for analytic univalent functions to be in $\mathcal{S}_{q}^{\ast }(\alpha )$ and we prove that this condition is also necessary for the functions in the class $\mathcal{TS}_{q}^{\ast }(\alpha )$. We also obtain extreme points, distortion bounds, covering result, convex combination and convolution properties for the functions in the class $\mathcal{TS}_{q}^{\ast }(\alpha )$.
Racismo, el extremo de la desigualdad
Authors: Russo Juan
Published: April 2023

"La premisa (y promesa) fundamental sobre la que se asienta el edificio ideal (y parcialmente real) de la democracia, es la igualdad de los integrantes de la comunidad política. La ciudadanía es la forma jurídica de esa igualdad, en política y en otros campos. La participación electoral, y la participación política en general, son posibles, como lo mostró Alessandro Pizzorno, sólo si se acepta la igualdad ciudadana. Las propias libertades pueden expandirse a medida que la igualdad se expande hacia distintas esferas, para usar la expresión de Michael Walzer. Libertad y participación, derechos y deberes ciudadanos se efectivizan y concretan en la misma medida en que se efectiviza y concreta la igualdad entre quienes integran la comunidad política. La dura constatación que se presenta en los trabajos que componen el dossier del numero 6 de RELASP, “Afrodescendientes de América Latina. Racismo y desigualdad estructural desde una perspectiva postcolonial” coordinado por Rocío Vera Santos, Sérgio H. Rocha Franco y Eduardo Luis Espinosa, es que las oscuras facetas del racismo, ocurren a la luz del día en democracias de América Latina. La región no sólo es un continente destacado por los niveles altos de desigualdad socioeconómica, sino también por no poder superar todavía el extremo de la desigualdad..."
“A lo mejor yo soy auto-racista”
Authors: Moreno Figueroa Mónica G. , Nicte-Ha López Chávez América
Published: April 2023

En este artículo exploraremos el racismo internalizado como una condición inevitable de las estructuras de opresión racista en el contexto mexicano y de su proyecto racial, el mestizaje. El racismo internalizado da cuenta de la capacidad de los grupos blanco-mestizos dominantes para conseguir el consentimiento de las personas subordinadas racialmente para ‘aceptar’ su propia opresión, es decir, las formas en las que las personas y colectivos somos coaccionados a aceptar la inferioridad y la superioridad racial. El análisis que presentamos se basa en una serie de entrevistas con personas negras e indígenas en México. Las formas en las que el racismo internalizado apareció en los datos nos ayudan a explorar la perversidad de los sistemas opresivos y las maneras insidiosas en las que se distribuye su efectividad y afectividad en las prácticas y discursos sociales. Hemos identificado una serie de tres dinámicas o lógicas que demuestran las formas de operación del racismo internalizado: lógicas de inmovilización, de desarticulación y de distracción. Todas estas lógicas abonan al proceso de deshumanización racista. Estas lógicas no tienen límites rígidos, sino que se van empalmando, encontrando, amalgamando y todas contribuyendo al conglomerado de experiencias acumulativas que van cimentando la experiencia de inferiorización.
Design of Hybrid Energy System for Railway Application (Case Study of People Mover System in Doha, Qatar)
Authors: Nugroho Sri , Mauludin Luthfi Muhammad , Sirait Togar , Mujiman Mujiman , Sofyan Ahmad , Tohir Toto
Published: April 2023

This paper presents the conceptual design of hybrid energy system used in railway application. The hybrid system with batteries and energy storage double-layer capacitor is a new technology that is used under extreme climatic conditions, especially in daytime temperature up to 50°C, high relative humidity, dust and heavy rain. It is a combination of double-layer capacitors and traction batteries. It draws power both externally and from braking energy. In order to reduce CO2 emissions to the environment, energy-saving drives and energy storage are used. Also, in public transportation, Sitras Hybrid Energy System (HES), hybrid energy storage system for trams, has been developed which combines a double-layer capacitor with a nickel-metal hydride battery. The storage not only allows driving without overhead lines, it also enables braking energy to be recovered. A reliable cooling system is required to ensure that the performance of the battery and the capacitor storage is maintained for as long as possible. The results of finite element model showed the robustness for railway application. The computational model refers to proof of static and dynamic strength in accordance with EN12663. A cooling system for a tram using this innovative technology was designed and qualified for the "Qatar Education City People Mover System (PMS)" project.
Characterization Of Oil Palm Empty Fruit Bunch and Coconut Shell for The Production of Fuel Briquettes
Authors: Manga Gila Layindeh , Abioyec Adekunle Moshood , Mohammed Jibril , Markus Markus
Published: April 2023

In this study, characterization of agricultural waste (oil palm empty fruit bunch, coconut shell and cassava peel) was done before and after carbonization. Briquettes were produced from the carbonized OPEFB and CS blends with CP as binder. Muffle furnace was used for the carbonization of both biomass; CS was carbonized at 7000C at 60 minutes residence time and OPEFB was carbonized at 4000C at 30 minutes residence time. Proximate analysis showed that raw OPEFB and CS had volatile matter of 70.89 and 63.76wt% which indicates easy ignition but high burning rate. They had low fixed carbon of 18.13 and 17.60wt% for OPEFB and CS respectively which accounted for their low calorific value of 19.61 and 20.70 MJ/kg respectively. Ultimate analysis showed insignificant nitrogen and sulfur content from both biomass. The carbonized OPEFB and CS showed improved Calorific value of 28.38 and 27.91 MJ/kg respectively. This was as a result of devolatilization of the biomass with enrichment of carbon from 45.04 to 69.28wt% for OPEFB and 48.02 to 75.50wt% for CS. The briquettes formed had a mean calorific value, compressive strength, burning rate and density of 27.40 MJ/kg, 2.138 N/mm2, 1.110 g/min and 912.26 kg/m3respectively. With these performance indicators, these selected agricultural wastes biomass could be helpful for production of fuel alternatives for domestic heating in developing and underdeveloped countries that produce such waste.
Opioid-Related Side Effects and Complications After Intrathecal Morphine Trial or Pump Implantation
Authors: Sul Jung Hoon , Hong Da Hoon , Yang Joo Chul , Kim Tae Wan , Park Kwan Ho
Published: April 2023

Objective: A few cases of post-surgical spine syndrome (PSSS) are resistant to standard treatment. Intrathecal morphine (ITM) therapy can be used to achieve improved pain control with fewer side effects compared to systemic analgesics alone. ITM-associated complications may be associated with the intrathecal catheter, implanted pump, device management, and the drugs themselves.Methods: Twenty-six patients with PSSS were retrospectively evaluated. All patients had visual analog scale (VAS) scores of 7 or higher, which continued for more than 6 months, and all received a single dose of the ITM trial. If the VAS score was reduced by 50%, and there were no side effects from the trial, ITM pump (ITMP) implantation was performed for continuous morphine injection to control pain. Of the 26 patients, 19 underwent only the ITM trial, and 7 in whom the VAS decreased by more than 50% after the trial further underwent ITMP implantation. Patients who underwent only the trial were observed for an average of 5.4 days (range: 3–14 days), and those who underwent ITMP implantation were observed for an average of 55.9 months (range: 15–123 months). The occurrence of side effects following ITM injection and complications related to the ITM trial or ITMP implantation were analyzed. Results: The most common complications were drug side effects (n=11), followed by procedural (n=1) and equipment (n=1) side effects. The most common symptoms were urinary difficulty (n=8) and pruritus (n=3). Serious complications included a large lumbosacral subdural hematoma, intradural fibrotic tissues at the lumbar puncture site, and urinary retention (n=1). A case of mid-catheter occlusion caused by precipitated morphine crystals and skin infection on an implantable pulse generator was also reported (n=1). In another case, skin necrosis was observed in the surgical area (n=1). Conclusion: The most common drug-related side effect is urination difficulty, and patients generally recover within a few days after the ITM trial. Complications, such as procedure-related subdural bleeding or IT catheter blockage, may also occur. A better understanding of IT drugs, equipment, and meticulous procedural techniques, can allow a reduction of complications.
SOSYAL SERMAYE VE İNOVASYON: OECD ÜLKELERİ ÜZERİNE AMPİRİK BİR ANALİZ
Authors: ERCAN Mahmure
Published: April 2023

Bireylerin çevresi ile iş birliği içerisinde ve koordineli hareket etmesini sağlayan her türlü ilişkisi sosyal sermaye olarak tanımlanır. Sanayi devrimi sonrasında ekonomide yaşanan hızlı gelişmeler, sosyal sermayenin de değişmesine neden olmuştur. Bireyler arası ilişkileri temsil eden sosyal sermaye giderek zayıflamıştır. 1980’li yıllarda, zayıflayan sosyal sermayenin ekonomiyi olumsuz etkilediği gerçeğinin fark edilmesi ile sosyal sermaye önem kazanmaya başlamıştır. Bu alanda pek çok çalışma yapılmıştır. Ancak yapılan çalışmalar sosyal sermayenin neden azaldığı, neden kıt kaynak haline dönüştüğü sorularını araştırmak yerine, sosyal sermayenin inovasyon ve ekonomik büyümeye pozitif etkisi üzerine yoğunlaşmıştır. Üstelik ekonomi için önemli olduğu kabul edilmesine ve ekonomi üzerindeki etkisi devamlı araştırılmasına rağmen, tersine ilişkinin durumu ihmal edilmiştir. Çalışma, literatürdeki bu eksikliği gidermek amacıyla hazırlanmıştır. İnovasyonun sosyal sermaye üzerindeki etkisi OECD ülkeleri üzerinden analiz edilmiştir. 2013-2017 yıllarına ait seçilen örneklem panel regresyon analizi ile tahmin edilmiştir. Tahmin sonucunda, inovasyonun sosyal sermaye üzerinde anlamlı ve negatif etkisi olduğu bulgusuna ulaşılmıştır. Buna göre çıkar üzerine kurulu bir iş ilişki, iş birliği de içerse sosyal sermayeyi beslememektedir.
АНАЛІЗ ДИНАМІЧНОЇ СТРУКТУРИ ОБ’ЄКТА
Authors: Димова Г. О.
Published: April 2023

Стаття присвячена обговоренню постановки задачі і схеми її розв’язання в найпростішому варіанті аналізу динамічної структури об’єкта – виділення в класі динамічних операторів D, що враховується при цьому заздалегідь відомим, оператором D0 , відповідного статистичним властивостям зареєстрованого сигналу. На етапі аналізу – виділення класу – необхідно вирішити загальні питання: за апріорними даними про досліджуваний об’єкт обґрунтовано обираємо один з типів оператора (функціональний, диференціальний, інтегральний або інтегро-диференціальний). При цьому необхідно враховувати і попередню інформацію, отримувану з сигналу. При дослідженні нерегульованого об’єкта має значення те, що сигнали завжди описують поведінку об’єкта як цілого і відображують індивідуальні рухи великого числа його однотипних мікрочастин. Аналіз структури автономного об’єкта за його встановленим сигналом недостатній, якщо враховувати тільки динамічну залежність від часу, навіть сама детальна реєстрація єдиного розв’язання динамічного рівняння, що встановилося не дозволяє в реальних ситуаціях розкрити структуру оператора D0 . Непристосованість звичайної схеми чорної скриньки для вивчення нерегульованого об’єкта за сигналом, що встановився, призводить до необхідності обліку внутрішніх флуктуацій в рівняннях сигналу об’єкта. Тому у статті обмежуємося розглядом автономних об’єктів, в динамічні рівняння яких час t у явному вигляді не входить. Сформульовано і обґрунтовано загальний простий принцип опису сигналу, властивості якого кількісно суттєві і регулярно проявляються за даних умов спостереження. Згідно основним положенням властивості сигналу зв’язуються між собою деякою динамічною структурою об’єкта. Дослідження статистичних властивостей відгуку динамічної системи на флуктуаційне обурення F t дозволяє оцінювати за сигналом, що встановився, динамічні характеристики нерегульованого об’єкта.
СТРАТЕГІЧНІ ПЕРСПЕКТИВИ РОЗВИТКУ АПК УКРАЇНИ НА МІЖНАРОДНОМУ РИНКУ
Authors: Дунська А. Р. , Білих М. С.
Published: April 2023

В умовах глобалізації економіки, високого рівня мінливості зовнішнього середовища та посилення галузевої конкуренції аграрний бізнес залишається важливою складовою національної економіки та рушієм розвитку на зовнішніх ринках. Саме тому, в статті досліджено питання розвитку агропромислових компаній України на міжнародному ринку у рамках визначення їх стратегічних перспектив. Авторські результати дослідження ґрунтуються на опрацюванні значної кількості джерел відкритого доступу, наукових робіт вітчизняних та зарубіжних вчених, а також нормативно-правових актів. Проведене дослідження, що викладене у статті, надає можливість визначити, що до початку повномасштабного вторгнення Росії на територію України вітчизняний сектор виробництва аграрної продукціє вважався ключовим гравцем на світовому ринку та щорічно нарощував дохід від здійснення експортної діяльності. Окреслено основні тенденції та ключові проблеми розвитку вітчизняного сектору АПК, який більшою мірою орієнтований на реалізацію сировини, що є негативним фактором. Охарактеризовано актуальний стан функціонування та тенденції розвитку галузі АПК на глобальному ринку, що передбачає постійні цінові коливання, перевищення пропозиції над попитом та вимагає дотримання міжнародних стандартів якості та безпечності продукції. Досліджено вплив війни на функціонування вітчизняного сектору агропромисловості та виявлено, що через воєнні діє втрачено велику кількість посівних площ і поголів’я птахів та великої рогатої худоби на півдні України, розірвано логістичні сполучення, зруйновано та пошкоджено виробничі потужності і заміновано поля на територіях бойових дій. Як результат окреслено основні цілі та стратегічні перспективи розвитку АПК України до яких відносяться диверсифікація логістичних сполучень з країнами-експортерами, забезпечення високого рівня якості продукції, відповідно до міжнародних стандартів, створення доданої вартості продукції АПК за рахунок переробки сировини та підвищення рівня державного сприяння розвитку сектору АПК.