bluuebunny/crossref_metadata_2025 huggingface dataset:
Making Solid Organic Fertilizer as Use of Livestock Waste in Jatisari Village, Kebumen
Authors: Rokhmaniyah Rokhmaniyah , Ardiatama Ghazi Inzanul , Rahmasari Hanidya , Rahayu Shiva Ayusa Kusumaning
Published: January 2024

Tujuan program pengabdian ini adalah memberikan penyuluhan dan praktik pembuatan pupuk organik dengan bahan utama yaitu kotoran kambing. Kegiatan pelatihan dilakukan di Desa Jatisari, Kecamatan Kebumen, Kabupaten Kebumen. Melalui kegiatan ini ditargetkan untuk ibu-ibu PKK, karang taruna, dan masyarakat Desa Jatisari. Pembuatan pupuk organik dilatarbelakangi oleh penggunaan pupuk kimia secara terus-menerus sebagai pupuk tanaman.  Adapun, limbah organik di Desa Jatisari tersedia dalam jumlah yang cukup. Penggunaan pupuk kimia dalam jangka waktu yang lama akan mengubah sifat kimia, fisika, dan biologi tanah sehingga mengurangi kesuburan tanah. Penggunaan pupuk organik secara berkelanjutan akan memperbaiki sifat dan tekstur tanah. Pembuatan pupuk organik dilakukan melalui 3 sesi utama, yaitu sesi penyuluhan, sesi praktik pembuatan, dan sesi penyempurnaan dan evaluasi. Teknik pengumpulan data melalui pelatihan langsung. Hasil yang diharapkan adalah pupuk organik dari kotoran kambing yang siap digunakan di lahan pertanian untuk mengurangi penggunaan pupuk kimia. Untuk itu, penyuluhan dan praktik ini diberikan supaya dapat menjadi salah satu solusi untuk mengembalikkan kesuburan tanah pertanian masyarakat Desa Jatisari dan memanfaatkan limbah kotoran ternak.
Socialization of Manufacturing Methods Traditional Drink from Telang Flowers in The Wonosari Village Community
Authors: Wahyudi Wahyudi , Salma Muthi'ah , Pradana Yoyan Ega , Fitriyaningsih Uchti , Mindandi Zati Hulwani
Published: January 2024

Bunga Telang merupakan jenis tanaman liar yang tumbuh subur di beberapa daerah di Indonesia. Bunga Telang bermanfaat sebagai penyembuh berbagai macam penyakit seperti asma, diabetes, kolesterol, dan juga dapat sebagai bahan minuman, bahan pewarna makanan serta kosmetik. Namun, pemanfaatan bunga Telang tersebut belum banyak diketahui oleh warga Desa. Tujuan kegiatan ini adalah untuk meningkatkan pemahaman masyarakat tentang (1) pemanfaatan bunga Telang, (2) cara pembuatan minuman tradisional dan zat pewarna makanan dari bunga Telang. Kegiatan ini menggunakan metode sosialisasi, demonstrasi, dan praktik membuat minuman dari bunga Telang. Kegiatan ini diikuti oleh warga masyarakat, khususnya ibu-ibu PKK Desa Wonosari. Hasil kegiatan ini adalah (1) meningkatnya pemahaman masyarakat tentang kebaradaan dan pemanfaatan bunga Telang, (2)  meningkatnya pengetahuan masyarakat tentang cara membuat minuman tradisional dan zat pewarna makanan dari bunga Telang. Simpulannya adalah kegiatan ini berjalan dengan lancar dan memberikan manfaat bagi masyarakat tentang pemanfaatan bunga Telang.
Pelatihan Pembelajaran Membaca Al - Qur’an pada Profesi Juru Parkir dan Tukang Becak Berbasis Pondok Pesantren di Baitul Maal Umat Sejahtera Mulia Kebumen
Authors: Sukataman Sukataman , Makmun Syukron
Published: January 2024

Baitul maal Umat Sejahtera Mulia (USM) Kebumen merupakan lembaga nirlaba (lembaga non profit yang konsern dalam seosial keagamaan), juga memberikan perhatian khusus terhadap pendidikan agama islam bagi 8 asnaf. Tujuan dari pengabdian ini adalah agar mereka yang berprofesi sebagai juru parkir dan tukang becak tidak melupakan kewajibannya sebagai seorang muslim, karena kebanyakan dari mereka sibuk mencari rizki dan lupa dengan amalan agamanya.  Metode pengabdian yang digunakan adalah dengan menggunakan CBPR (Community Based Parsipatory Research), dimana penulis memposisikan sebagai jembatan antara USM dengan komunitas orang yang berprofesi juru parkir dan tukang becak. Sedangkan metode pembelajaran yang diterapkan dalam pelatihan berbasis metode pembelajaran di pondok pesantren yaitu sorogan, bandongan dan menghafal. Melalui metode tersebut, peserta pelatihan diharapkan bisa membaca Al - Quran dengan baik dan benar. Hasil pelatihan bahwa 80 % para peserta sangat mudah memahami, mudah mempraktikkan dalam membaca Al-Qur’an secara benar sesuai kaidah tajwid.  Sehingga penulis menyimpulkan bahwa metode pengadbdian CBPR dengan menerapkan metode pembelajaran di Pondok Pesantren sangat membantu para juru parkir dan tukang becak dalam membaca Al – Qur’an dengan benar sesuai kaidah tajwid.
The Influence of Augmented Reality (AR) Based Learning Media on Elementary School Students' Learning Interest in Human Digestive System Material
Authors: Samsiyanawati Umi , Ikebayu Dinda Rizky , R Sandra Ayu , Wijayanti Murwani Dewi
Published: January 2024

Pemanfaatan teknologi dalam dunia pendidikan sangat diperlukan karena pembelajaran dituntut untuk menggunakan media yang menarik salah satunya yaitu dengan memanfaatkan teknologi Augmented Reality (AR). Tujuan penelitian ini adalah mengkaji penggunaan media pembelajaran berbasis Augmented Reality (AR) terhadap minat belajar siswa sekolah dasar. Metode penelitian yang digunakan adalah pendekatan kualitatif yang bersifat deskriptif melalui teknik pengumpulan data kajian literatur. Hasil dari penelitian ini adalah penggunaan media Augmented Reality (AR) dapat memberikan pengaruh terhadap minat belajar siswa sekolah dasar, dimana siswa merasa tertarik dan senang dalam mengikuti pembelajaran. Dengan demikian, dapat disimpulkan bahwa penggunaan media pembelajaran berbasis Augmented Reality (AR) dapat mempengaruhi minat belajar siswa sekolah dasar.
Implementation of the Quantum Learning Model for Improving Science Content Learning Outcomes for Class IV Students at SD Inpres Kampung Baru
Authors: Abdillah Widy , Rahayu Dewi Puji , Purwanty Ratna
Published: January 2024

Tujuan penelitian ini yaitu meningkatkan hasil belajar Muatan IPA Siswa Kelas IV SD Inpres Kampung Baru dengan mengimplementasikan model pembelajaran Quantum Learning. Jenis penelitian ini yaitu penelitian tindakan kelas (PTK) dan dilakukan sebanyak 2 siklus. Setiap siklus terdiri dari perencanaan, pelaksanaan, observasi, dan refleksi. Subjek penelitian ini yaitu siswa kelas IV SD Inpres Kampung Baru yang berjumlah 16 siswa. Teknik pngumpulan data menggunakan tes dan observasi. Hasil penelitian menunjukan bahwa impelementasi model pembelajaran Quantum Learning dapat meningkatkan hasil belajar siswa Kelas IV SD Inpres Kampung Baru. Siklus I terdapat 11 yang tuntas (68,75%),dan 5 siswa yang belum tuntas (31,25%) dengan nilai rata-rata 65,87. Sedangkan pada siklus II terdapat 15 siswa yang tuntas (93,75%) dan 1 siswa yang belum tuntas (6,25%) dengan nilai rata-rata 80,25.
Profil Kemampuan Literasi Sains Siswa Kelas V Sekolah Dasar Negeri Padarek III
Authors: Handayani Teny Okty , Wijayanti Murwani Dewi , Suryandari Kartika Chrysti
Published: January 2024

IPA merupakan Ilmu pengetahuan yang mempelajari tentang alam semesta beserta isinya oleh karena itu IPA sangat penting untuk di pelajari sama seperti  literasi sains dalam IPA. Penelitian ini bertujuan untuk mendeskripsikan profil kemampuan literasi sains dan kemampuan kognitif siswa kelas V SD Negeri Padarek III Majalengka.  SD Negeri Padarek III merupakan pendidikan formal dasar bagi siswa untuk mendapatkan pembelajaran sains dan mengenal apa yang dimaksud dengan sains dalam pembelajaran. Sains merupakan ilmu yang berhubungan dengan alam yang di perkenalkan kepada siswa sejak usia dini. Penelitian ini memiliki sampel siswa di SD sebanyak 25 siswa. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif. Hasil penelitian menunjukan bahwa literasi sains dan kognitif pada siswa kelas V SD Negeri Padarek III Majalengka masih rendah yaitu pada tahun 2023 hanya terdapat 32% siswa kelas V yang memiliki kemampuan literasi sains. Rendahnya literasi sains dan kognitif, disebabkan siswa cenderung belum memahami konsep-konsep sains dan kognitif secara benar. Siswa memiliki latar belakang yang masih minim dalam pengetahuan IPA, terutama dalam literasi sains. Siswa juga terkendala oleh faktor internal dan eksternal yang dapat mempengaruhi dalam kemampuan literasi sains.
Movement Analysis of Water Rocket Game as Supporting Motivation and Problem Solving Skills of Elementary Students
Authors: Farudin Firman Wahyu , Rusydi Fahmi Muafa , Asirwada Putra Nadzif Yuanditama
Published: January 2024

Permainan roket air adalah  salah  satu  jenis  permainan edukatif yang banyak mengandung konsep fisika.  Meskipun  pembuatan  roket  air  menggunakan  teknik dan bahan  yang sederhana  namun diperlukan  analisis  tinggi  dalam  setiap  pergerakkan  roket air.Penelitian ini bertujuan untuk merancang alat peragaroket air dan menganalisis faktor-faktor yang mempengaruhi  gerak peluncuran  roket  air  sebagai  sarana  untuk  mengembangkan  keterampilan problem solving. dan  keterampilan  berpikir kreatif. Hasil  eksperimen  menunjukkan  bahwa:  1)  untuk menghasilkan jarak peluncuran terjauh,  roket air didesain menggunakan baling-baling berbentuk  trapesium  dan  volume  botol  sebesar  1500  mL  serta  sudut  lempar  45°.  2) Percepatan  gravitasi  bumi  menghasilkan  nilai rata-rata sebesar (menunggu perhitungan) m/s2.Hasil  penelitian ini dapat  digunakan  sebagai  bahan  referensi  bagi  guru  untuk  merancang  media pembelajaran  IPA  yang kreatif sehingga dapat meningkatkan motivasi belajar siswa dan mengembangkan  keterampilan  problem  solving.
Utilizing Used Galon as Green Technology Innovation for Science Learning at Sanggar Bani
Authors: Haryanto Ridho Tri , Istaqimi Faizuna , Wijayanti Murwani Dewi
Published: January 2024

Green Technology merupakan ilmu praktis yang berguna secara berkelanjutan bagi manusia menggunakan prinsip 3R ( Reduce, Reused, and Recycle). Galon bekas merupakan contoh jenis sampah plastik yang tidak cepat terurai sehingga perlu proses daur ulang untuk mengurangi pencemarannya. Penelitian ini menerapkan konsep Green Technology dengan memanfaatkan galon bekas menjadi media hidroponik. Hidroponik merupakan media yang edukatif yang banyak mengandung konsep IPA. Media hidroponik berbahan galon bekas sebagai peraga pembelajaran IPA dalam mengembangkan pemahaman siswa dan kemampuan literasi saintifik anak-anak. Penelitian ini bertujuan untuk mengetahui proses pembuatan media pembelajaran hidroponik berbahan dasar galon bekas sekaligus memahami struktur bagian tubuh tumbuhan. Penelitian juga bertujuan untuk memudahkan dalam melakukan pengamatan pertumbuhan tumbuhan yang ditanam. Penelitian menggunakan metode deskriptif kualitatif. Hasil yang didapat pada penelitian ini, yaitu 1) anak-anak menjadi memahami cara membuat dan merawat tanaman pada media hidroponik,dan  2) anak-anak menjadi mengetahui struktur bagian tumbuhan dan proses pertumbuhannya secara langsung. Hasil penelitian dapat digunakan sebagai bahan referensi bagi guru untuk merancang media pembelajaran IPA yang kreatif sehingga dapat mengembangkan pemahaman dan kemampuan literasi saintifik anak.
Assistance in Creating Scientific Based Pop Up Book Learning Media for Elementary Teachers
Authors: Winarni Endang Widi , Yusnia Yusnia , Agusdianita Neza
Published: January 2024

Pendampingan pembuatan media pop up book berbasis saintifik bagi guru sekolah dasar bertujuan untuk meningkatkan pemahaman tentang media pembelajaran, media pembelajaran berbasis saintifik, dan keterampilan dalam pembuatan media pop up book berbasis saintifik. Metode yang digunakan adalah observasional dan modelling dengan empat fase, yaitu: fase perhatian, fase retensi, fase reproduksi, dan fase motivasi. Teknik pengumpulan data yang digunakan adalah observasi, dokumentasi, dan penyebaran angket. Hasil kegiatan pendampingan menunjukkan peningkatan, yakni: (1) pemahaman guru tentang media pembelajaran dengan rata-rata pretest sebesar 80,84 dan posttest sebesar 92,85; (2) pemahaman tentang media pembelajaran berbasis saintifik dengan rata-rata pretest sebesar 80,67 dan posttest sebesar 95,33, dan (3) keterampilan guru dalam pembuatan media pop up book berbasis saintifik dengan rata-rata pretest sebesar 70,22 dan posttest sebesar 89,92. Simpulan dari artikel ini adalah pendampingan pembuatan media pop up book berbasis saintifik dapat meningkatkan pemahaman tentang media pembelajaran, media pembelajaran berbasis saintifik, dan keterampilan dalam pembuatan media pop up book berbasis saintifik.
ANALISIS RUGI-RUGI HEAT RATE PLTU BANTEN 3 LONTAR AKIBAT DEVIASI PARAMETER PADA KONDISI AKTUAL MENGGUNAKAN ANALISIS GAP
Authors: Wahyudi Teguh , Yuriadi Kusuma
Published: January 2024

Steam power plant (PLTU) is one type of energy conversion technology to generate electricity from fossil materials. The performance of a PLTU unit will begin to decline as the unit ages. In addition to age, performance degradation can also be caused by deviation of operating parameters, which can cause heat rate losses. The purpose of this study is to determine the performance of PLTU Banten 3 Lontar unit 2 by analyzing heat rate losses due to parameter deviations according to actual conditions and calculating cost savings and possible improvements. The research methodology used is an evaluation method where the actual data of operating parameters will be compared with the baseline data. The comparison will produce a deviation value, which is then used to obtain the value of heat loss, cost loss, and improvement recommendations for the plant. Baseline data is obtained from the interpolation equation of commissioning testing at 3 different variation loads. From the study, it is known that there was an increase in Nett Plant Heat Rate (NPHR) with an average of 561 kCal / kWh. The increase in NPHR occurred due to heat rate losses, where the decrease in turbine HP efficiency was the main cause, with an average loss of 87.96 kCal / kWh or 24.53% of total losses. Assuming that all heat rate losses during testing can be corrected, the average potential energy savings per day is 8,604,802 kCal/kWh, while the average cost savings are Rp1,534,046,000/month.
INOVASI DESAIN KUNCI PAS MENGGUNAKAN CATIA V5R20 DENGAN PENDEKATAN ANTROPOMETRI (STUDI KASUS PADA PT. KARYA BAHANA UNIGAM DIVISI PEMELIHARAAN MESIN)
Authors: Medikano Alsen , Anissa Aprilya  , Azisah Nur Aini
Published: January 2024

Since the occurrence of the Covid-19 pandemic in early 2020 in Indonesia, it has been necessary to maintain the body's immunity so that it remains stable so that the body is not easily exposed to the virus. For that, PT Karya Bahana Unigam needs to do something that can facilitate the maintenance of press machines by innovating on wrenches as a tool to simplify the machine maintenance process. The innovation that was carried out on this spanner started with distributing questionnaires to machine maintenance operators at PT Karya Bahana Unigam with the aim of knowing the needs of users and knowing the technical characteristics of these innovative products. After making the House of Quality (HOQ), anthropometric calculations are carried out to determine the dimensions of the Wrench innovation product to be made. The results of anthropometric calculations show that the spanner product length is 32.2 cm, the spanner innovation product width is 5 cm, and the spanner product width is 1.34 cm. The design was made using CATIA V5R20 software with a 3-dimensional design form, and drafting was also carried out to find out the design from various views. The folding wrench design consists of 3 components, namely a size 17 spanner, a size 13 spanner, and a pin as a key hinge.
SIMULASI ALIRAN FLUIDA PADA INSTALASI GASIFIKASI TIPE DOWNDRAFT
Authors: Wijianto Agus , Alfitrah Fajar
Published: January 2024

The development of energy is very important to maintain oil reserves and also substitute for fossil fuels. Agricultural waste can be used as an alternative raw material to assist in the depletion of petroleum reserves and increase the use value of agricultural waste. Gasification is a process that converts energy into syngas that can be used for fuel. Fluid flow simulation research in the downdraft was conducted to determine the effect of the heat distribution or temperature on the gasification equipment installation and the effect of the cooling water mass flow rate on the airflow out of the reactor. Numerical study method using computational fluid dynamic solidworks flow simulation software. The fixed variables in the simulation are inlet air velocity 1.27, 1.36, and 1.49 m/s where this figure is obtained from an experiment to test the characterization of the downdraft actual the simulation in the reactor shows the temperature of the combustion reactor is 800-850ºC to be 400-450ºC at the reactor output. The simulation on the heat exchanger is carried out to reduce the air temperature to the temperature operating engine. The heat exchanger uses water fluid with a mass flow rate of 0.05 kg/s. The best simulation is obtained at the variation of air velocity 1.27 m/s and temperature reactor 900ºC where the output temperature is 92.11ºC. Doing a new experiment on gasification, then doing a simulation first, will make the gasification work easier.
Influência da temperatura na resistividade elétrica do concreto e na cinética de corrosão da armadura
Authors: Chaves Chiaradia Lucas , Rosa Almeida Fernando do Couto , Paulino Aguilar Maria Teresa , Pazini Figueiredo Enio José
Published: January 2024

O trabalho avaliou a influência da variação de temperatura nas medidas de resistividade elétrica e na cinética de corrosão em estruturas de concreto armado sujeitos a cloretos. Os concretos foram caracterizados fisicamente e mecanicamente aos 28 e 90 dias. Após 204 dias, as amostras foram submetidas a ciclos de ida e volta de temperatura partindo dos 55°C até   -5°C. Os resultados indicaram que a cinética de corrosão e a resistividade elétrica variaram com a alteração da temperatura. Em temperaturas mais elevadas, os traços contaminados com Cl- demonstraram uma alta probabilidade de corrosão e uma diminuição dos valores de resistividade elétrica. Porém, na temperatura negativa a probabilidade de corrosão foi insignificante e os valores de resistividade elétrica os mais elevados.
Diagnóstico y proyecto de recalce estructural del Palacio Tampieri
Authors: Zanni Enrique Santiago , Capdevila Julio Alfredo
Published: January 2024

Se detalla el diagnóstico y recalce estructural del Palacio Tampieri, dentro de un proyecto de restauración integral. El edificio posee alto valor patrimonial, constituyendo uno de los dos palacios existentes en la Provincia de Córdoba, Argentina. Presenta fracturas en mamposterías portantes, provocadas por asentamientos diferenciales, al estar fundado sobre limos colapsables afectados por variaciones cíclicas del nivel freático. La metodología consistió en relevar las lesiones existentes, realizar cateos e indagación técnica e histórica de su construcción para diagnosticar su estado estructural y constructivo. La intervención se dividió en dos etapas: A) estabilizar y hermetizar el edificio, y B) rehabilitar y restaurar fachadas e interiores. Se concluye que los micropilotes hincados constituyen una alternativa válida para refundar edificios en suelos saturados, con intervenciones mínimamente destructivas.
Health education and self-care in primary health care in patients with type 2 diabetes mellitus: protocol for a randomized clinical trial
Authors: Ceretta Luciane Bisognin , Miranda Vanessa , Helal Lucas , Vieira Andriele , Tuon Lisiane Generoso , de Farias Joni Marcio , Tomasi Cristiane Damiani
Published: January 2024

Objective: Testing a model of Health Education and self-care, based on the transtheoretical model of behavior change by Prochaska and DiClemente, on glycemic control, and important clinical and behavioral variables, against usual care, in patients with difficult-to-manage Type 2 Diabetes Mellitus.
Methods: randomized, parallel, phase III clinical trial, with allocation ratio of 1:1, duration of 6 months, with primary endpoint HbA1c (%) between groups at the end of 6 months. The RCT will be conducted in the assigned territory of the patients, in order to reinforce the student-educator bond and the adherence of patients to the trial.
Statistical Analysis Plan: descriptive analyses will be presented in continuous and categorical data, accompanied by the respective dispersion measures. Hypothesis tests will be performed for inferential analysis. For all conclusions related to primary and secondary endpoints, the intention-to-treat principle will be used as the primary analysis, accompanied by per-protocol analyses. Generalized linear models or mixed effects models will be used depending on the pattern of missing data found arising from intra-unit variability. Three interim safety reviews will be scheduled, performed by an independent panel, for potential early termination due in the case of harm, in accordance with the rules established by the study for patient safety. Stata 17.0.0 and R 4.3.1 statistical packages will be used for analysis, graphs, and figures.
Test registration number: Brazilian Registry of Clinical Trials (RBR-5w2sqt); Pre-results.
The Relationship Between Low T3 and Disease Severity in Patients With Acute Pancreatitis
Authors: can Başak , Kahvecioğlu Esra Deniz
Published: January 2024

Sick euthyroid syndrome is a change in thyroid hormones because of functional deterioration in the hypothalamic-pituitary-thyroid axis in critically ill patients. We aimed to show that deterioration in thyroid function tests can be used as an indicator of severity and prognosis in pancreatitis despite a healthy thyroid gland. The study was designed as retrospective, single center. Patients diagnosed with acute pancreatitis between May 2020 and June 2021 were evaluated. Acute pancreatitis was classified according to the 2012 revised Atlanta criteria. Patients were categorised as sick euthyroid syndrome and euthyroid group and compared in terms of biochemical parameters and, scorings such as Ranson 0, Ranson 48, Glasgow, Balthazar, Bisap. A total of 152 patients were included in the study. Eighty-three patients (54%) were euthyroid. Sixty-nine patients (46%) had sick euthyroid syndrome with low serum free T3 level and high/normal TSH level. Free T3 was lower in the sick euthyroid syndrome group than in the euthyroid group. (1.5 ± 0.04 vs 2.6 ± 0.04, respectively p < 0.0001) In the sick euthyroid syndrome group, Ranson 0 (1.5 ± 0.1 vs 0.9 ± 0.1 p = 0.001), Ranson 48th Hour (1.8 ± 0.1 vs 1.1 ± 0.1 p < 0.0001 ), Glasgow (2.4 ± 0.2 vs 1.3 ± 0.1 p < 0.0001), Atlanta (p = 0.007) and Balthazar (2.1 ± 0.1 vs 1.4 ± 0.1) p = 0.001) scores were found to be significantly higher than the euthyroid group. Sick euthyroid syndrome gives an idea about the prognosis in acute pancreatitis. We showed that free T3 value is a significant parameter that may be used to indicate the prognosis of acute pancreatitis.
Robust Optimal Generalized Backstepping Approach to Stabilize and Control Hyper-Chaotic System
Authors: Fallah-Morteza-Nejad S.A. , Mazinan Amir Hooshang , Siahkali H.
Published: January 2024

The issue of controlling non-linear systems is one of the most challenging and attractive topics in all applied sciences and industries. So, it has drawn the attention of many researchers and industrialists. One of the challenges in this field is the lack of a comprehensive and structured control method that can be implemented. Therefore, in this paper presents a novel back-stepping method to stabilize and control hyper-chaotic systems considering the uncertainty in chaotic parameters. The proposed algorithm comprises of an improved backtracking method which applies Lyapunov's theory. In This work, the simulation time is optimized and the tracking error is reduced while the robustness feature is improved. The proposed robust optimal generalized backstep method (ROGBM) is validated by a FMND hyper-chaotic system which is controlled by the internal stabilization and tracking the reference signal. The simulation is performed by MATLAB software. The simulation result reveals the higher efficiency of the proposed controller. The proposed design has an improved performance in reference signal tracking and internal stabilization compared with the conventional GBM method.
Fingerprint Based Localization Enabled by Low-Rank Matrix Reconstruction in Intelligent Reflective Surface Assisted Networks
Authors: duan shiru , zhang yuexia , Liu Ruiqi
Published: January 2024

The intelligent Reflective Surface (IRS) is a novel network node that consists of a large-scale passive reflective array to obtain customized reflected wave direction by modulating the amplitude, phase, which can be easy deployed to change the wireless signal propagation environment and enhance the communication performance under Non-Line-of Sight (NLOS) environment where location services cannot be performed accurately. In this paper, a low-rank matrix reconstruction enabled fingerprint-based localization algorithm for IRS-assisted networks is proposed. Firstly, a 5G positioning system based on IRSs is constructed using multiple IRSs deployed to reflect signals. This enables the base station to overcome the influence of NLOS and thus receive the positioning signal of the point to be positioned. Then, the angular domain power expectation matrix of the received signal is extracted as fingerprint to form a partial fingerprint database. As a next step, the complete fingerprint database is reconstructed using the low-rank matrix fitting algorithm, thereby considerably reducing the workload of building the fingerprint database. Finally, maximal ratio combining is used to increase the gap between the fingerprint data, and the Weighted K-Nearest Neighbor (WKNN) algorithm is used to match the fingerprint data and estimate the location of the points to be located. The simulation results demonstrate the feasibility of the proposed method to achieve a sub-meter accuracy in a NLOS environment.
Dynamic control simulation of a new lower limb prosthesis model with energy recovery during walking, using magnetorheological fluids
Authors: Cojocaru Dorian , Vladu Ionel Cristian , Pană Cristina Floriana , Copilusi Cristian , Manta Liviu Florin , Mariniuc Alexandru Marin
Published: January 2024

Researchers can now utilize new materials to create innovative models for lower limb prostheses and explore novel ways to use them for efficient dynamic control. To achieve user-friendliness, one area of research focuses on recovering and reusing kinetic walking energy for dynamic control. This paper proposes a new design for a magnetorheological (MR) valve, along with a rotary actuator which offers a dynamic control for a lower limb prosthesis. The design will allow the storage of the energy during heel and mid-foot contact phases and to utilize it during toe support to lift the foot off the ground and establish a balance for the lower limb prosthesis. The energy is transferred through a magnetorheological hydraulic circuit and stored using a pneumatic system. The speed of energy transfer is regulated by magnetorheological valves. A series of MR valve designs were proposed and evaluated experimentally, which allowed the identification of the most suitable variant in the targeted application context. The design of the lower limb prosthesis was simulated using SolidWorks, and its dynamic behaviour was analysed in ANSYS.
Adverse Event Profiles of CDK4/6 inhibitors: A pharmacovigilance analysis of the FDA Adverse Event Reporting System (FAERS) database
Authors: Tian Xiaojiang , Chen Lin , Chen Yonghong , He Yi , Zhang Ni
Published: January 2024

Background: Cyclin-dependent kinase 4/6 inhibitors (CDK4/6 inhibitors) have changed the therapeutic landscape of HR+ and HER2− advanced breast cancer. The safety profile of CDK4/6 inhibitors has not yet been systemically analysed in the real world. This study aimed to provide a comprehensive understanding of AEs associated with CDK4/6 inhibitors andthe factors that influence them using the FAERS database.
Methods: FAERS data (2014Q1 to 2022Q4) were searched for reports of all FDA-approved CDK4/6 inhibitors across all indications. We used the standardized MedDRA query (SMQ) generalized search AEs on the preferred term (PT) level based on case reports. After filtering duplicate reports, disproportionality analysis was used to detect safety signals by calculating reporting odds ratios (RORs). Reports were considered statistically significant if the 95% confidence interval did not contain the null value.
Results: Within the standardized MedDRA queries, significant safety signals were found, including those for palbociclib [haematopoietic leukopenia (ROR=14.93), erythropenia (ROR=11.12)], ribociclib [haematopoietic leukopenia (ROR=10.81), conduction defects (ROR=8.40)], and abemaciclib [eosinophilic pneumonia (ROR=7.86), dehydration (ROR=5.88)]. For AEs at the PT level, we found several significant blood and lymphatic system disorders for both palbociclib and ribociclib, such as abnormal full blood count (ROR=46.45) and decreased white blood cell count (ROR=33.13) for palbociclib and anisocytosis (ROR=54.84), neutropenia (ROR=14.88) for ribociclib. Palbociclib also had high RORs for pseudocirrhosis, stomatitis, oral pain, and alopecia, while ribociclib had high RORs for electrocardiogram PR shortened, sinus arrhythmia, and blood bilirubin abnormal. However, the RORs were significant for abemaciclib in terms of diarrhoea (ROR=15.06), vena cava thrombosis (ROR=10.45), thrombophlebitis migrans (ROR=27.08) and pneumonitis (ROR=10.05).
Conclusion: CDK4/6 inhibitors differed in their safety profile reports; for example, neutropenia mainly occurs with palbociclib and ribociclib, diarrhoea and venous thromboembolism mainly occur with abemaciclib, and QTc prolongation mainly occurs with ribociclib. Individualized drug administration according to patients' conditions is needed in clinical practice.
Oral NAC and post-infectious symptoms of COVID-19 and its biological role
Authors: Yang Jingjing , Shan Lina
Published: January 2024

Background
N-acetylcysteine (NAC), as a precursor of glutathione, may decrease oxidative stress in the body when the body's immunity is disrupted and may play an anti-inflammatory and immune-regulating function to safeguard the body's stability. In clinical practice, the qualities of NAC are also employed to patients with viral hepatitis and sepsis and are now being aggressively stressed in the treatment of coronavirus disease 2019 (COVID-19). NAC supplementation might restore this redox balance and decrease adverse evolution in individuals with COVID-19. to explore if there is a change in patients' symptoms after infection when taking the drug before infection.
Methods
This study was done at the Affiliated Hospital of Jinzhou, Liaoning, China, to explore whether medication may affect symptoms after coronavirus disease 2019 (COVID-19). In this study, 219 patients who were infected with COVID-19 and have been on NAC for a while.They were questioned about their cough and sputum, myalgia, fever, dizziness, exhaustion, and anxiety after infection by telephone.
Results
After stratification, there were no significant changes in age, gender, and comorbidities among the three groups of varied age groups, and the baseline values were equal.Our results found that the relationship between NAC administration and symptoms was significant in patients who had few external interfering factors and were well themselves.
Conclusions
NAC may have a favorable impact on the symptoms of COVID-19. The feedback impact of NAC is more prominent in individuals who have a preponderance of their own health state, lifestyle behaviors, and age.
Long-term effects of local radiotherapy on growth and vertebral features in children with high-risk neuroblastoma
Authors: YANG KYUNGMI , Ahn Joong Hyun , Woo Sook-Young , Jung Sang Hoon , Sung Ki Woong , Lee Ji Won , Lim Do Hoon
Published: January 2024

Background To evaluate the effects of local radiotherapy (RT) on growth, we evaluated the chronological growth profiles and vertebral features of children with high-risk neuroblastoma.
Methods Thirty-eight children who received local photon or proton beam therapy to the abdomen or retroperitoneumbetween January 2014 and September 2019 were included. Simple radiography of the thoracolumbar spine was performed before and every year after RT. The height and vertical length of the irradiated vertebral bodies (VBs) compared with the unirradiated VBs (vertebral body ratio, VBR) were analyzed using the linear mixed model. Shape feature analysis was performed to compare the irradiated and unirradiated vertebrae.
Results The follow-up was a median of 53.5 months (range, 21-81­ months) after RT. A decline in height z-scores was mainly found in the early phase after treatment. In the linear mixed model with height, the initial height (fixed, p < 0.001), sex (time interaction, p = 0.008), endocrine dysfunction (time interaction, 0.019), and age at diagnosis (fixed and time interaction, both p = 0.002) were significant. Unlike the trend in height, the change in VBR (ΔVBR) decreased gradually (p < 0.001). The ΔVBR in the group that received more than 30 Gy decreased more than in the group that received smaller doses. In the shape feature analysis, the irradiated VBs changed to a more irregular surface that were neither round nor rectangular.
Conclusion The irradiated VBs in children were gradually restricted compared to the unirradiated VBs in long-term follow-up, and higher RT doses were significantly affected. Radiation-induced irregular features of VBs were observed.
Effects of Fire on Physical and Chemical Properties of Soil on Burned and Unburned Sample in Fwangnin Bokkos District, Nigeria
Authors: Wuyep Solomon Zitta , Rampedi Isaac Tebogo , Ifegbesan Ayodeji Peter , Muhire Innocent
Published: January 2024

Slash and burnt method of agriculture have both detrimental and beneficial effects on soil fertility. Hence this study examined the effects of bush burning on soil fertility. Purposive sampling technique was used to select four samples of 500 grams of soil, two each for burned and unburned soil were collected within a depth of 0-15cm. These sampled were tested to determine their physio-chemical properties using various methods. Student’s T test was used to evaluate the significant difference of burned and unburned samples. Study revealed an increased level in soil pH, EC; N, P, exchangeable bases (Ca, Mg and Na) and coarse soil texture (sand). However, there is a decrease in soil OC, CEC, OM, K, clay and silt properties such as texture and mineralogy in the burned soil. The T test analysis indicated that there is significant difference between burned and unburned soil samples on the physical and chemical properties at p<0.021 with a mean square of -2.622. Results of the study shows that physio-chemical properties differed between burned and unburned soil samples. It is recommended that farmers should be sensitized on the implications of slash and burnt to fertility of the soil.
Multicenter Propensity Score-Matched Analysis to Compare Perioperative Morbidity After Laparoscopic or RoboticComplex Hepatectomy for Solitary Hepatocellular Carcinoma
Authors: Huang Xiao-Kun , Fu Tian-Wei , Xu Zhu-Ding , Jin Lei , Du Cheng-Fei , Gao Zhen-Yu , Wang Kai-Di , Dai Mu-Gen , Liu Si-Yu , Lu Wen-Feng , Zhong Zhi-Han , Ye Tai-Wei , Xiao Zun-Qiang , Cheng Jian , Shen Guo-Liang , Liu Jie , Liu Jun-Wei , Huang Dong-Sheng , Zhang Cheng-Wu , Liang Lei
Published: January 2024

Background & Aims Postoperative complications are vital factors affecting the prognosis of patients with hepatocellular carcinoma (HCC), especially for complex hepatectomy. The present study aimed to compare perioperative complications between laparoscopic and robotic complex hepatectomy (LCH vs. RCH).
MethodsPatients with solitary HCC after complex hepatectomy were collected from a multicenter database. Intraoperative variables and postoperative morbidity were compared to assess perioperative risk. Propensity score-matched (PSM) analysis was adopted to overcome selection bias. Multivariable logistic regression was performed to determine the independent risk factors.
Results 436 patients were included eventually. Among them, 385 patients received LCH, and 51 patients received RCH. After PSM, the results showed that compared to LCH, RCH had lower rates of intraoperative blood loss and transfusion, as well as lower postoperative 30-day, major mortality, and post-hepatectomy liver failure (PHLF) (all P < 0.05). Additionally, the length of hospital stay was shorter in the RCH group (P = 0.026). Multivariable analysis showed RCH is an independent protective factor for reducing the 30-day mortality (OR 0.657, 95%CI 0.361-0.983, P = 0.046), major mortality (OR 0.709, 95%CI 0.512-0.899, P = 0.043) and PHLF (OR 0.765, 95%CI 0.221-0.978, P = 0.044).
Conclusion RCH has advantages over LCH in the minimally invasive treatment of complex HCC, as it can reduce the incidence of intraoperative blood loss and postoperative mortality, especially for major mortality and PHLF. Therefore, robotic surgery should be considered for patients with HCC who require complex hepatectomy.
Identification of NEK6 as a potential biomarker for prognosis in glioma
Authors: Wang Danwen , Wang Zisong , Xu Jian , Cai Yuxiang , Liu Xiaoping , Li Zhiqiang
Published: January 2024

Never in mitosis gene A-related kinase 6 (NEK6) is involved in mitotic cell cycle. However, the characteristics and roles of NEK6 in pan-cancer remain incomplete. The objective of the present study is to comprehensively explore the prognostic value of NEK6 and its potential functions in multiple cancers, especially in gliomas. In this study, we conducted of comprehensive analyses of NEK6 in pan-cancer, including expression profile, immune characteristics and its relationship with clinical prognosis. We found that NEK6 was significantly upregulated in gliomas. And the increased level of NEK6 was significantly associated with poor clinical prognoses of tumor patients. Moreover, the single-cell analysis revealed that NEK6 overexpression was highly related to malignant cells and Mono/Macrophages in glioma tissue. spebrutinib and barasertib were identified to be targeted therapeutic drugs for gliomas. Then, the prognostic role of NEK6 was further validated using an independent glioma cohort, and confirmed that the highly expression of NEK6 in glioma was positively correlated with poor prognosis in patients with glioma. In vitro experiment demonstrated that knockdown of NEK6 hindered the growth and migration capacity of the glioma cells, leading to a halt in the G2/M phase of the cell cycle and triggering apoptosis in glioma cell lines. Taken together, our data uncovered the prognostic value, therapeutic potential, and molecular insight of NEK6 in glioma.
Impact and Resiliency of the Early Phase of the COVID-19 pandemic on Healthcare Providers and their Household Members
Authors: Kim Hannah J. , Nguyen Minh , Duck Meghan , Lo Yin , Huang Vivian , Kennedy Lori , Dawson-Rose Carol , Hong OiSaeng
Published: January 2024

The COVID-19 pandemic has a significant impact on the health of healthcare providers and their families. The purpose of this study is to assess the impact of COVID-19 on the resiliency of frontline healthcare providers and their household members. A cross-sectional survey was conducted in 2 different medical centers. The Brief Resilience Scale (BRS) assessed resiliency, and the Impact of Event Scale-Revised (IES-R) assessed subjective self-reported distress caused by traumatic events. Fisher tests was used hypothesis testing of differences in BRS and IES-R scores, between healthcare vs. non-healthcare providers. Random forest models were used to identify the top contributors to BRS and IES-R scores. Participants also provided free text responses to describe main losses in social and support networks. A total of 1271 participants completed the surveys. The majority (95%) of the participants were self-identified healthcare providers. The mean (SD) BRS and IES-R score for non-healthcare providers (n = 63) were 20.1 (SD 5.2) and 24.0 (SD 16.4), respectively. The average score of IES-R indicated a concern for post-traumatic stress disorder (PTSD). The average score of the BRS was under the range of normal resilience (18–25.9). There were no statistically significant differences in resiliency (p = 0.90) and impact of event (p = 0.59) between healthcare and non-healthcare provider household members. Having someone to confide in is one of the most important factors contributing to resiliency and impact of event. The average IES-R score suggested that all participants were impacted by the COVID-19 pandemic and demonstrated same level of resiliency.
Exploring the potential differences local anesthesia in dental treatment by pharmacokinetic approaches
Authors: Li Yanchen , Liu Shupeng , Yu Mengyang , Ou Minyi , Wu Xiaofei , Wan Kuo , Wang Hongyun
Published: January 2024

Objective: Mastering the characteristics of local anesthetic techniques is essential for dentists to make appropriate anesthetic protocols. Different from the supraperiosteal infiltration anesthesia, periodontal ligament anesthesia appears to provide faster onset and shorter duration, and has the potential to be the first-choice for supplemental anesthesia according to clinical observations. However, there has been few fundamental scientific data to support it. Here, we aimed to explore the differences between periodontal ligament and supraperiosteal infiltration anesthesia in view of pharmacokinetics.
Materials and Methods: A total of 10 participants were sequentially administered 0.3ml of 4% articaine with 1:100,000 epinephrine by periodontal ligament, supraperiosteal and intravenous injection in 3 cohorts, with a wash-out period of 1 week. Serial blood samples were collected for pharmacokinetic evaluation. Meanwhile, we initially explored the anesthesia effect and safety for these local anesthesia approaches.
Results: The pharmacokinetic parameters of articaine by periodontal ligament and supraperiosteal injection were as follows: AUC0-t (55.5 and 67.3 h·ng/mL), Cmax (192.6 and 142.5ng/mL), t1/2 (26.8 and 28.5 min) and CL/F (254.3 and 161.6 L/h). There was no significant statistical difference in these pharmacokinetic parameters except for Tmax (1.0 vs 10.0 min), which may be closely related to the onset of action. The bioavailability obtained by intravenous injection as reference were 55.7% and 66.9% respectively.
Conclusions: Our study may explain that periodontal ligament anesthesia had faster onset than supraperiosteal infiltration anesthesia in view of pharmacokinetics, and provided initial evidence that periodontal ligament anesthesia could be the first-choice for supplemental anesthesia.
Clinical Relevance: This study provided the novel approach to explore the local anesthetic effect from the pharmacokinetic characteristics of systemic circulation. Based on our results, the dentists would benefit from the perception of the difference between periodontal ligament and supraperiosteal infiltration anesthesia, as this information might capture important scientific information when managing the dental anesthesia technique. Additionally, periodontal ligament anesthesia presented a faster onset of action than supraperiosteal infiltration anesthesia, which would be the first choice for supplemental anesthesia.
Relationship between helium isotopes and focal depths of low-frequency earthquake, Northeastern Japan
Authors: Yamazaki Yukino , Narita Arisa , Umeda Koji , Sumino Hirochika , Maeda Takuto , Amano Tadashi
Published: January 2024

Low-frequency earthquakes (LFEs) observed around volcanoes are often interpreted as reflecting the boundary of the magma transport channels or magma reservoirs. On the other hand, the occurrence of mantle-derived helium is closely related to current or recent magmatism in subduction zones, owing to mantle melting being the primary mechanism for the transfer of primordial 3He from the mantle to the lithosphere. The elevated 3He/4He ratios observed surrounding volcanoes could indicate the presence of a magmatic plumbing system. Therefore, it is meaningful to to investigate the relationship between the helium isotope variations and the location of LFEs in volcanic regions. There appears to be good correlation between helium isotope ratios and focal depths of LFEs observed in 31 volcanic regions of Northeast Japan. These findings indicate that the shallower the depth of the magma reservoir, the smaller the contamination of primordial helium with crustal radiogenic helium, resulting in higher helium isotopes observed at the surface. Many volcanic hazard factors, such as the probability and duration of an eruption, the eruption style, and the probability of triggering large landslides or caldera collapses, are related to the depth of the magma source. As a result, helium isotope monitoring surrounding volcanoes could provide an early clue to the behavior of ascending magma and future volcanic eruptions.
High prevalence of severe pain is associated with low opioid availability in patients with advanced cancer: Combined database study and nationwide questionnaire survey in Japan
Authors: Hasegawa-Moriyama Maiko , Morioka Yasuhide , Hiroi Shinzo , Naya Noriyuki , Suzuki Yura , Koretaka Yuichi , Hara Erina , Abe Hiroaki , Uchida Kanji , Sumitani Masahiko
Published: January 2024

Objectives
Opioid availability for the palliative care of patients with advanced cancer is increasing globally. However, opioid availability remains extremely low in Japan. We investigated whether pain is appropriately controlled by low-dose opioid prescriptions in patients with advanced cancer in Japan.
Methods
A web-based nationwide survey for caregivers from 2000 community comprehensive support care centers was performed in Japan to assess details about pain in the 30 days before patients died of end-stage cancer. Separately, the data for opioid prescription doses and medical services in the 90 days before the death of patients with cancer were extracted from a health insurance claim database.
Results
Responses from 1034 responders were retrieved and 665 patients were included. In total, 254 patients (38.2%) complained of severe-to-intolerable cancer-related pain. The median cumulative prescription dose of opioids in the 90 days before patient death was 311/0 mg by oral morphine equivalent doses. Multiple regression analyses across prefectures revealed that the proportion of patients with severe-to-intolerable cancer-related pain was negatively associated with the cumulative opioid consumption expressed as morphine-equivalent doses within 90 days before death.
Conclusions
The very low availability of opioids for patients with end-stage cancer could result in high rate of severe-to-intolerable cancer-related pain patients. The increase in the absolute dose of opioids could improve the palliative care framework to the pain-control levels of the global standard.