bluuebunny/crossref_metadata_2025 huggingface dataset:
Increasing the Efficiency of Turbine Inlet Air Cooling in Climatic Conditions of China through Rational Designing—Part 1: A Case Study for Subtropical Climate: General Approaches and Criteria
Authors: Radchenko Mykola , Yang Zongming , Pavlenko Anatoliy , Radchenko Andrii , Radchenko Roman , Koshlak Hanna , Bao Guozhi
Published: August 2023

The enhancement of gas turbine (GT) efficiency through inlet air cooling, known as TIAC, in chillers using the heat of exhaust gas is one of the most attractive tendencies in energetics, particularly in thermal engineering. In reality, any combustion engine with cyclic air cooling using waste heat recovery chillers might be considered as a power plant with in-cycle trigeneration focused on enhancing a basic engine efficiency, which results in additional power output or fuel savings, reducing carbon emissions in all cases. The higher the fuel efficiency of the engine, the more efficient its functioning as a source of emissions. The sustainable operation of a GT at stabilized low intake air temperature is impossible without using rational design to determine the cooling capacity of the chiller and TIAC system as a whole to match current duties without overestimation. The most widespread absorption lithium-bromide chillers (ACh) are unable to reduce the GT intake air temperature below 15 °C in a simple cycle because the temperature of their chilled water is approximately 7 °C. Deeper cooling air would be possible by applying a boiling refrigerant as a coolant in ejector chiller (ECh) as the cheapest and simplest in design. However, the coefficients of performance (COP) of EChs are considerably lower than those of AChs: about 0.3 compared to 0.7 of AChs. Therefore, EChs are applied for subsequent cooling of air to less than 15 °C, whereas the efficient ACh is used for ambient air precooling to 15 °C. The application of an absorption–ejector chiller (AECh) enables deeper inlet air cooling and greater effects accordingly. However, the peculiarities of the subtropical climate, characterized by high temperature and humidity and thermal loads, require extended analyses to reveal the character of thermal load and to modify the methodology of designing TIAC systems. The advanced design methodology that can reveal and thereby forecast the peculiarities of the TIAC system’s thermal loading was developed to match those peculiarities and gain maximum effect without oversizing.
Perspectives on the Development of Technologies for Hydrogen as a Carrier of Sustainable Energy
Authors: Beschkov Venko , Ganev Evgeniy
Published: August 2023

Hydrogen is a prospective energy carrier because there are practically no gaseous emissions of greenhouse gases in the atmosphere during its use as a fuel. The great benefit of hydrogen being a practically inexhaustible carbon-free fuel makes it an attractive alternative to fossil fuels. I.e., there is a circular process of energy recovery and use. Another big advantage of hydrogen as a fuel is its high energy content per unit mass compared to fossil fuels. Nowadays, hydrogen is broadly used as fuel in transport, including fuel cell applications, as a raw material in industry, and as an energy carrier for energy storage. The mass exploitation of hydrogen in energy production and industry poses some important challenges. First, there is a high price for its production compared to the price of most fossil fuels. Next, the adopted traditional methods for hydrogen production, like water splitting by electrolysis and methane reforming, lead to the additional charging of the atmosphere with carbon dioxide, which is a greenhouse gas. This fact prompts the use of renewable energy sources for electrolytic hydrogen production, like solar and wind energy, hydropower, etc. An important step in reducing the price of hydrogen as a fuel is the optimal design of supply chains for its production, distribution, and use. Another group of challenges hindering broad hydrogen utilization are storage and safety. We discuss some of the obstacles to broad hydrogen application and argue that they should be overcome by new production and storage technologies. The present review summarizes the new achievements in hydrogen application, production, and storage. The approach of optimization of supply chains for hydrogen production and distribution is considered, too.
The Use of Tail as a Minimal-Invasive Method to Detect a Large Set of Biochemical Responses in the Italian Wall Lizard Podarcis siculus (Rafinesque, 1810)
Authors: Moltedo Ginevra , Martuccio Giacomo , Catalano Barbara , Simbula Giulia , Vignoli Leonardo
Published: August 2023

Conventional methods to analyze biochemical processes related to contaminant toxicity usually require the sacrifice of animals to collect tissues and organs. However, for ethical reasons and especially for endangered species, non- or minimal-invasive methods should be preferred. Among vertebrates, reptiles show a general decline worldwide and therefore the use of non- or minimal-invasive methods to measure some biochemical processes in these animals are encouraged. It is well known that most lizards use a common safety behavior implying the natural loss of tail in the case of predation events. Therefore, if common analyses testing contaminant toxicity could be performed in tail tissue, this method, not implying the sacrifice of the animals, could be considered as a good minimal-invasive method. The aim of this study is to test on wild Italian wall lizard Podarcis siculus the use of tail to detect a large set of biomarkers including oxidative stress (TOSCAROO, TOSCAOH, CAT, tGSH, MDA), biotransformation processes (EROD, GSTs) and neurotoxicity (AChE, BChE). All the biochemical responses, excluding EROD and MDA, resulted to be analytically detectable in tail tissues of P. siculus, although the mean values obtained with this minimal-invasive method were significantly lower than those obtained with invasive one.
Reuse of Lake Sediments in Sustainable Mortar
Authors: Martellotta Audrey Maria Noemi , Petrella Andrea , Gentile Francesco , Levacher Daniel , Piccinni Alberto Ferruccio
Published: August 2023

The study analyses the possible valorisation of lake sediments for sustainable mortar, in accordance with the principles of the circular economy, to obtain a sustainable material, since reuse occurs without any kind of preliminary treatment and preserves the consumption of virgin raw materials in the mix design. Moreover, it reduces the amount of water to be used in the mix since part of it is already contained in the sediments. The research was performed on sediments dredged from two artificial reservoirs, Camastra and San Giuliano, located in Basilicata, a region in southern Italy. Cement mortar was prepared by completely replacing, at different quantities, the fine aggregate and, for some of it, partially replacing, at a constant quantity, part of the binder. Workability, mechanical strength, and density were measured, as well as the possible release of contaminants. The investigations made it possible to assess the influence of replacing aggregate with sediment on mortar performance, showing that San Giuliano sediment produces mortar with great workability (~140%), comparable to that of normalised mortar. Similarly, the mechanical strengths of some specimens (SG_s1 and SG_s2) were approximately 60 MPa and 52 MPa, respectively (about 15% higher than that of normalised mortar). On the contrary, for the mortar prepared with the Camastra sediments, both workability and mechanical strength were ~50% lower than normalised mortar. Furthermore, the leaching test did not reveal contaminant release.
Fire Incidents, Trends, and Risk Mitigation Framework of Electrical Vehicle Cars in Australia
Authors: Hassan Md Kamrul , Hameed Nazra , Hossain Md Delwar , Hasnat Md Rayhan , Douglas Grahame , Pathirana Sameera , Rahnamayiezekavat Payam , Saha Swapan
Published: August 2023

Electric Vehicles (EVs) offer a promising solution to reduce the environmental impact compared to internal combustion engine vehicles. However, EV adoption in Australia has been hindered by concerns over fire safety. This study aims to comprehensively analyse EV fire risks and trends in Australia, including those related to charging stations and lithium-ion batteries. The research utilises secondary data from various reputable sources to develop statistical forecasting models, which estimate that Australia will have approximately 1.73 million EVs by 2030 and 15.8 million by 2050. The study reveals an average EV fire frequency of six fires per million EVs in Australia, aligning with the global average. Consequently, Australia is expected to experience 9 to 10 EV fire incidents annually in 2030, 37 to 42 EV fire incidents annually in 2040, and 84 to 95 EV fire incidents annually in 2050. To address these risks, an EV fire risk control framework is considered to identify and recommend appropriate measures for life safety, lithium-ion batteries, charging, EV handling, and EV locations. This research provides vital evidence for regulators, policymakers, and the fire industry to effectively manage EV fire risks and enhance preparedness for the growing EV market in Australia.
Morphological and Trophic Features of the Invasive Babka gymnotrachelus (Gobiidae) in the Plain and Mountainous Ecosystems of the Dniester Basin: Spatiotemporal Expansion and Possible Threats to Native Fishes
Authors: Afanasyev Sergey , Hupalo Olena , Tymoshenko Nataliia , Lietytska Olena , Roman Anatolii , Manturova Oksana , Bănăduc Doru
Published: August 2023

Over the last few years, the racer goby B. gymnotrachelus quickly expanded in the mountainous rivers of the Dniester basin at aheight of 300 m a.s.l. and above. The occurrence frequency of the racer goby in fish communities in the mountainous rivers of the Carpathian ecoregion remains low (up to 20%), as compared with the plain rivers, where the species occurs in 70–100% of cases. The major prey groups in its diet in both plain and mountainous were Chironomidae, Diptera, and Crustacea. Chironomidae formed the maximal portion (35% at an occurrence frequency of 72.5%), and Trichoptera formed 18%at an occurrence frequency of 41%, whereas fish larvae were absent in their diet in mountainous rivers. The peculiar environmental conditions of mountainous rivers caused the adaptive modifications of the morphological features of the racer goby at the subpopulation level, which compriseda decrease inthe specimens’ size in rivers with a flow velocity of above 1.5 m/s and rivers with pebble contentsof above 50%in the bottom sediments.The modifications showed an increase inbody streamlining as an adaptation to flow velocity and turbulence and the stony substrate of the river’s bottom. Thus, the morphological adaptation of B. gymnotrachelus to the conditions of the mountainous rivers is in progress, and the formationof astable population in these rivers can be expected. In contrast, the native fish species’ resilience in the face of newcomers is still high, and this is because their alevins are not food for invaders.
Effect of Serpentine Flow Field Channel Dimensions and Electrode Intrusion on Flow Hydrodynamics in an All-Iron Redox Flow Battery
Authors: Krishnappa Rakesh Basavegowda , Subramanya S. Gowreesh , Deshpande Abhijit , Chakravarthi Bharatesh
Published: August 2023

This paper presents a study on flow hydrodynamics for single-channel serpentine flow field (SCSFF) and cross-split serpentine flow field configurations (CSSFF) for different geometric dimensions of channel and rib width ratios with electrode intrusion over varying compression ratios (CRs) in an all-iron redox flow battery. Pressure drops (Δp) measured experimentally across a cell active area of 131 cm2 for different electrolyte flow rates were numerically validated. A computational fluid dynamics study was conducted for detailed flow analyses, velocity magnitude contours, flow distribution, and uniformity index for the intrusion effect of a graphite felt electrode bearing a thickness of 6 mm with a channel compressed to varying percentages of 50%, 60%, and 70%. Experimental pressure drops (Δp) over the numerical value resulted in the maximum error approximated to 4%, showing good agreement. It was also reported that the modified version of the cross-split serpentine flow field, model D, had the lowest pressure drop, Δp, of 2223.4 pa, with a maximum uniformity index at the electrode midplane of 0.827 for CR 50%, across the active cell area. The pressure drop (Δp) was predominantly higher for increased compression ratios, wherein intrusion phenomena led to changes in electrochemical activity; it was found that the velocity distribution was quite uniform for a volumetric uniformity index greater than 80% in the felt.
Determining the Possibilities of Reducing Visible Quality Defects in Commercial Elements of Turkey Carcasses Using an Alternative Stunning Device
Authors: Banach Joanna Katarzyna , Żywica Ryszard , Grzywińska-Rąpca Małgorzata , Grzybowska-Brzezińska Mariola
Published: August 2023

The development of the quality and commercial value of poultry meat is related to the formation of visible quality defects (hemorrhages) in muscles during the first stage of production (stunning). The production of meat with an unusual appearance for the consumers affects their purchasing decisions and, consequently, the company’s economics. The aim of this research was to determine the possibility of reducing visible quality defects (large and small hemorrhages) in commercial turkey carcass elements (fillet, loin, wing) using an alternative device (AD) for the electrical stunning of animals in comparison to the quality effects obtained using the conventional device (CD) in plant X. The factors differentiating the experiment were the electrical current frequency (AD: 125, 400, 800, and 1600 Hz; CD: 50 Hz) and process time (9 and 18 s). The increase in electrical current frequency used in the alternative device stunner (own construction) resulted in changing the percentage share of defective turkey meat production. The greatest reduction of minor and severe meat defects and improvement of its quality were obtained for the alternative device at f = 800 Hz and t = 9 s—considered optimal for specific industrial conditions. Extending the time of stunning turkeys to 18 s had a positive effect on visible quality defects in the evaluated commercial elements of the carcass; however, its application in practice will depend on the efficiency of the slaughter line of the plant. A comparative analysis of the results of the impact of the frequency of electric current in the alternative device and plant X on the improvement of meat quality showed a justified need to commercialize the research results and replace the device currently used in the plant with an alternative one.
Salacia reticulata Extract Suppresses Fat Accumulation by Regulating Lipid Metabolism
Authors: Jung Jaeeun , Park Jeongjin , Lee Minhee , Kim Jinhak , Oh Dongchan , Jun Woojin , Kim Ok-Kyung , Lee Jeongmin
Published: August 2023

The excessive storage of triglycerides in adipose tissue is a characteristic feature of obesity, which arises from an imbalance between energy intake and expenditure. In this study, we aimed to explore the potential anti-obesity effects of Salacia reticulata extracts (SC) in a high-fat diet (HFD)-induced in obese mice and 3T3-L1 adipocytes, with a specific focus on understanding the underlying lipid mechanisms. Mice were fed with a normal diet (NC; normal control), HFD (60% high-fat diet), Met (HFD containing metformin 250 mg/kg b.w.), SC25 (HFD containing SC 25 mg/kg b.w.), SC50 (HFD containing SC 50 mg/kg b.w.), or SC 100 (HFD containing SC 100 mg/kg b.w.) for 12 weeks. Notably, SC supplementation led to significant reductions in body weight gain, adipose tissue weight, adipose tissue mass, and adipocyte size in HFD-fed mice. Furthermore, SC supplementation exerted inhibitory effects on the adipogenesis and lipogenesis pathways while promoting lipolysis and thermogenesis pathways in the adipose tissues of HFD-fed mice. In vitro experiments using 3T3-L1 cells demonstrated that SC treatment during the differentiation phase suppressed adipogenesis and lipogenesis, whereas SC treatment after differentiation, activated lipolysis and thermogenesis. Collectively, these findings indicate that SC exhibits a direct influence on the lipid metabolism of adipocytes, making it an effective candidate for weight loss interventions.
The Scoop on SCOBY (Symbiotic Culture of Bacteria and Yeast): Exploring Consumer Behaviours towards a Novel Ice Cream
Authors: Mehta Annu , Serventi Luca , Kumar Lokesh , Torrico Damir Dennis
Published: August 2023

With the growing demand for sustainable practises, the food industry is increasingly adopting circular economy approaches. One example is recycling the symbiotic culture of bacteria and yeast (SCOBY) used in kombucha fermentation to create value-added products. However, consumer acceptance of such novel products remains unclear. To address this, the present study examined consumer attitudes towards ice cream made with SCOBY as an ingredient and how this affected their intention to consume it. Drawing on the theory of planned behaviour (TPB) and additional constructs such as emotions and food neophobia, an online survey was conducted with New Zealand consumers (N = 170). Results showed that the TPB constructs significantly predicted the intention to consume SCOBY ice cream. Moreover, by adding emotions to the constructs, the model’s explanatory power was enhanced. Attitudes, subjective norms, and emotions were the main predictors of intention, which in turn was found to be the main predictor of behaviour. Participants’ beliefs about the safety and taste of SCOBY ice cream were significantly correlated with their intention and behaviour, as were the opinions of nutritionists/dietitians, friends, and family. The model accounted for 21.7% of the variance in behaviour and 57.4% of the variance in intention. These findings can be used to plan marketing strategies related to waste-to-value-added products such as SCOBY ice cream.
Predictive Modeling of Riboflavin Production in Lactiplantibacillus plantarum MTCC 25432 Using Fuzzy Inference System
Authors: Kumar Vikram , Arora Vinkel Kumar , Rana Ananya , Kumar Ankur , Taneja Neetu Kumra , Ahire Jayesh J.
Published: August 2023

Riboflavin (Vitamin B2) is an essential vitamin and a microbial metabolite produced by some lactic acid bacteria (LAB). This investigation aims to study the overproduction of riboflavin in selected Lactiplantibacillus plantarum strain by using the one factor at a time (OFAT) tool coupled with the Fuzzy Inference System (FIS) and its validation through fermentative production in semi-defined media. Out of three Lactiplantibacillus strains used in this study, the maximum riboflavin producing strain was selected based on its ability to grow and produce higher levels of riboflavin. In results, Lactiplantibacillus plantarum strain MTCC 25432 was able to produce 346 µg/L riboflavin in riboflavin deficient assay medium and was investigated further. By using the OFAT–fuzzy FIS system, casamino acid in the range of 5–20 g/L, GTP 0.01–0.04 g/L, sodium acetate 5–15 g/L, and glycine 5–15 g/L were used to predict their effect on riboflavin production. The conditions optimized with modeling showed a 24% increment in riboflavin production (429 µg/L) by Lactiplantibacillus plantarum MTCC 25432 vis-a-vis the unoptimized counterpart (346 µg/L). In conclusion, an FIS-based predictive model was effectively implemented to estimate the riboflavin within an acceptable limit of 3.4%. Riboflavin production enhancing effects observed with various levels of sodium acetate, casamino acid, and GTP could be useful to re-design matrices for riboflavin production.
Effects of Hydroxyethyl Cellulose and Sulfated Rice Bran Polysaccharide Coating on Quality Maintenance of Cherry Tomatoes during Cold Storage
Authors: Liu Guige , Chen Bingjie , Liu Hongru , Wang Xiao , Zhang Yi , Wang Cunfang , Liu Chenxia , Zhong Yaoguang , Qiao Yongjin
Published: August 2023

Cherry tomatoes are easily damaged due to their high moisture content. A composite coating was developed to delay deterioration and prolong storage by mixing antibacterial sulfated rice bran polysaccharides (SRBP) and edible hydroxyethyl cellulose (HEC) with film-forming properties. The effects of HEC, HEC-5% SRBP, and HEC-20% SRBP preservative coatings on the maintenance of the quality of cherry tomatoes (LycopersivonesculentumMill., Xiaohuang F2) during cold storage were investigated. The HEC-20% SRBP coating significantly reduced tomato deterioration and weight loss, delayed firmness loss, decreased polyphenol oxidase activity, and increased peroxidase activity. Furthermore, cherry tomatoes treated with HEC-20% SRBP maintained high levels of titratable acid, ascorbic acid, total phenols, and carotenoids. Cherry tomatoes coated with HEC-SRBP also had higher levels of volatile substances and a greater variety of these substances compared to uncoated tomatoes. In conclusion, the HEC-20% SRBP coating effectively delayed deterioration and preserved cherry tomatoes’ nutrient and flavor qualities during postharvest cold storage, suggesting it could be a novel food preservation method.
Entropy Generation and Control: Criteria to Calculate Flow Optimization in Biological Systems
Authors: Bicudo José , Nogueira-de-Sá Pedro , Chaui-Berlinck José
Published: August 2023

Living beings are composite thermodynamic systems in non-equilibrium conditions. Within this context, there are a number of thermodynamic potential differences (forces) between them and the surroundings, as well as internally. These forces lead to flows, which, ultimately, are essential to life itself, but, at the same time, are associated with entropy generation, i.e., a loss of useful work. The maintenance of homeostatic conditions, the tenet of physiology, demands the regulation of these flows by control of variables. However, due to the very nature of these systems, the regulation of flows and control of variables become entangled in closed loops. Here, we show how to combine entropy generation with respect to a process, and control of parameters (in such a process) in order to create a criterium of optimal ways to regulate changes in flows, the coefficient of flow-entropy (CJσ). We demonstrate the restricted possibility to obtain an increase in flow along with a decrease in entropy generation, and the more general situation of increases in flow along with increases in entropy generation of the process. In this scenario, the CJσ aims to identify the best way to combine the gain in flow and the associated loss of useful work. As an example, we analyze the impact of vaccination effort in the spreading of a contagious disease in a population, showing that the higher the vaccination effort the higher the control over the spreading and the lower the loss of useful work by the society.
A Mechanical Picture of Fractal Darcy’s Law
Authors: Damián Adame Lucero , Gutiérrez-Torres Claudia del Carmen , Figueroa-Espinoza Bernardo , Barbosa-Saldaña Juan Gabriel , Jiménez-Bernal José Alfredo
Published: August 2023

The main goal of this manuscript is to generalize Darcy’s law from conventional calculus to fractal calculus in order to quantify the fluid flow in subterranean heterogeneous reservoirs. For this purpose, the inherent features of fractal sets are scrutinized. A set of fractal dimensions is incorporated to describe the geometry, morphology, and fractal topology of the domain under study. These characteristics are known through their Hausdorff, chemical, shortest path, and elastic backbone dimensions. Afterward, fractal continuum Darcy’s law is suggested based on the mapping of the fractal reservoir domain given in Cartesian coordinates xi into the corresponding fractal continuum domain expressed in fractal coordinates ξi by applying the relationship ξi=ϵ0(xi/ϵ0)αi−1, which possesses local fractional differential operators used in the fractal continuum calculus framework. This generalized version of Darcy’s law describes the relationship between the hydraulic gradient and flow velocity in fractal porous media at any scale including their geometry and fractal topology using the αi-parameter as the Hausdorff dimension in the fractal directions ξi, so the model captures the fractal heterogeneity and anisotropy. The equation can easily collapse to the classical Darcy’s law once we select the value of 1 for the alpha parameter. Several flow velocities are plotted to show the nonlinearity of the flow when the generalized Darcy’s law is used. These results are compared with the experimental data documented in the literature that show a good agreement in both high-velocity and low-velocity fractal Darcian flow with values of alpha equal to 0<α1<1 and 1<α1<2, respectively, whereas α1=1 represents the standard Darcy’s law. In that way, the alpha parameter describes the expected flow behavior which depends on two fractal dimensions: the Hausdorff dimension of a porous matrix and the fractal dimension of a cross-section area given by the intersection between the fractal matrix and a two-dimensional Cartesian plane. Also, some physical implications are discussed.
Fractional Polynomial Models as Special Cases of Bayesian Generalized Nonlinear Models
Authors: Hubin Aliaksandr , Heinze Georg , De Bin Riccardo
Published: August 2023

We propose a framework for fitting multivariable fractional polynomial models as special cases of Bayesian generalized nonlinear models, applying an adapted version of the genetically modified mode jumping Markov chain Monte Carlo algorithm. The universality of the Bayesian generalized nonlinear models allows us to employ a Bayesian version of fractional polynomials in any supervised learning task, including regression, classification, and time-to-event data analysis. We show through a simulation study that our novel approach performs similarly to the classical frequentist multivariable fractional polynomials approach in terms of variable selection, identification of the true functional forms, and prediction ability, while naturally providing, in contrast to its frequentist version, a coherent inference framework. Real-data examples provide further evidence in favor of our approach and show its flexibility.
Production of Hydrogels from Microwave-Assisted Hydrothermal Fractionation of Blackcurrant Pomace
Authors: Inthalaeng Natthamon , Dugmore Tom I. J. , Matharu Avtar S.
Published: August 2023

The exploitation of unavoidable food supply chain wastes resulting from primary and secondary processing for chemicals, materials, and bioenergy is an important concept in the drive towards circular-based, resource-efficient biorefineries rather than petroleum refineries. The potential production of hydrogels (materials) from unavoidable food supply chain wastes, which are naturally rich in biopolymers such as cellulose, hemicellulose, pectin, and lignin, represents an interesting opportunity. However, these intertwined and interconnected biopolymers require separation and deconstruction prior to any useful application. Thus, this study aims to explore the formation of hydrogels from defibrillated celluloses (MW-DFCs) produced via acid-free stepwise microwave hydrothermal processing of blackcurrant pomace residues. Initially, pectin was removed from blackcurrant pomace residues (MW, 100–160 °C), and the resultant depectinated residues were reprocessed at 160 °C. The pectin yield increased from 2.36 wt.% (MW, 100 °C) to 3.07 wt.% (MW, 140 °C) and then decreased to 2.05 wt.% (MW, 160 °C). The isolated pectins were characterized by attenuated total reflectance infrared spectroscopy (ATR-IR), thermogravimetric analysis (TGA), and 13C NMR (D2O). The cellulosic-rich residues were reprocessed (MW, 160 °C) and further characterized by ATR-IR, TGA, and Klason lignin analysis. All the MW-DFCs contained significant lignin content, which prevented hydrogel formation. However, subsequent bleaching (H2O2/OH−) afforded off-white samples with improved gelling ability at the concentration of 5% w/v. Confocal laser microscopy (CLSM) revealed the removal of lignin and a more pronounced cellulosic-rich material. In conclusion, the microwave-assisted defibrillation of blackcurrant pomace, an exploitable unavoidable food supply chain waste, affords cellulosic-rich materials with the propensity to form hydrogels which may serve useful applications when put back into food products, pharmaceuticals, cosmetics, and home and personal care products.
Composite Hydrogel Modulates Intrinsic Immune-Cascade Neovascularization for Ocular Surface Reconstruction after Corneal Chemical Injury
Authors: Zhang Jun , Xi Kun , Deng Guohua , Zou Xi , Lu Peirong
Published: August 2023

Ocular alkali burns recruit neutrophils and triggers neutrophil extracellular trap (NET)-neovascularization cascade effects that limit ocular surface reconstruction and functional repair. However, effective inhibition of the release of neutrophil extracellular traps after a corneal chemical injury, coordination of intrinsic immunity with corneal repair, and exploration of more effective and non-invasive drug-delivery modes are still urgently needed. Using an in vitro coculture system, we found that an alkaline environment stimulates neutrophils to release NETs, which can be regulated by deoxyribonuclease I (DNase I). Inspired by this, we loaded DNase I, which effectively regulates NETs, onto chitosan nanoparticles and combined them with silk fibroin to construct a composite hydrogel that can sustainably regulate NETs. The hydrogel reduced neutrophil extracellular trap production by 50% and neovascularization by approximately 70% through sustained DNase I release after a corneal alkali burn. The complex hydrogel promotes ocular surface reconstruction by modulating the intrinsic immune-cascade neovascularization effect, providing a new research basis for the construction of nanobiomaterials that modulate pathological neovascularization.
Temporal Autocorrelation of Sentinel-1 SAR Imagery for Detecting Settlement Expansion
Authors: Kapp James , Kemp Jaco
Published: August 2023

Urban areas are rapidly expanding globally. The detection of settlement expansion can, however, be challenging due to the rapid rate of expansion, especially for informal settlements. This paper presents a solution in the form of an unsupervised autocorrelation-based approach. Temporal autocorrelation function (ACF) values derived from hyper-temporal Sentinel-1 imagery were calculated for all time lags using VV backscatter values. Various thresholds were applied to these ACF values in order to create urban change maps. Two different orbital combinations were tested over four informal settlement areas in South Africa. Promising results were achieved in the two of the study areas with mean normalized Matthews Correlation Coefficients (MCCn) of 0.79 and 0.78. A lower performance was obtained in the remaining two areas (mean MCCn of 0.61 and 0.65) due to unfavorable building orientations and low building densities. The first results also indicate that the most stable and optimal ACF-based threshold of 95 was achieved when using images from both relative orbits, thereby incorporating more incidence angles. The results demonstrate the capacity of ACF-based methods for detecting settlement expansion. Practically, this ACF-based method could be used to reduce the time and labor costs of detecting and mapping newly built settlements in developing regions.
Korean Medicine Clinical Practice Guideline Update for Temporomandibular Disorders: An Evidence-Based Approach
Authors: Kim Hyungsuk , Shim Jae Woo , Shin Woo-Chul , Lee Yoon Jae , Ha In-Hyuk , Kim Koh-Woon , Cho Jae-Heung
Published: August 2023

Many updated clinical research results have been published since the Korean Medicine Clinical Practice Guidelines (KMCPGs) for temporomandibular disorders (TMDs) were published in 2018. Therefore, it is necessary to update the existing clinical practice guidelines (CPGs). This study presents updated recommendations for TMD treatment based on current research data published up to February 2020. The draft version of the level of evidence and grade of recommendation was determined through an assessment of the risk of bias and a meta-analysis of selected literature based on the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). The final guidelines were derived using the Delphi method. Eighteen recommendations were derived for eight items of Korean medicine treatment for TMDs. Compared with previous Korean medicine CPGs for TMDs, the grades of seven recommendations, including acupuncture, pharmacopuncture, and Chuna manual therapy, were increased. The grades of the two recommendations have been changed. Six new recommendations were added to fully reflect clinical reality. Acupuncture, pharmacopuncture, and Chuna manual therapy are recommended for TMD patients in clinical practice. Concurrent conventional conservative therapy with Korean medicine or a combination of Korean medicines should be considered in clinical practice in patients with temporomandibular disorders.
Wearables for Stress Management: A Scoping Review
Authors: González Ramírez Maria Luisa , García Vázquez Juan Pablo , Rodríguez Marcela D. , Padilla-López Luis Alfredo , Galindo-Aldana Gilberto Manuel , Cuevas-González Daniel
Published: August 2023

In recent years, wearable devices have been increasingly used to monitor people’s health. This has helped healthcare professionals provide timely interventions to support their patients. In this study, we investigated how wearables help people manage stress. We conducted a scoping review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) standard to address this question. We searched studies in Scopus, IEEE Explore, and Pubmed databases. We included studies reporting user evaluations of wearable-based strategies, reporting their impact on health or usability outcomes. A total of 6259 studies were identified, of which 40 met the inclusion criteria. Based on our findings, we identified that 21 studies report using commercial wearable devices; the most common are smartwatches and smart bands. Thirty-one studies report significant stress reduction using different interventions and interaction modalities. Finally, we identified that the interventions are designed with the following aims: (1) to self-regulate during stress episodes, (2) to support self-regulation therapies for long-term goals, and (3) to provide stress awareness for prevention, consisting of people’s ability to recall, recognize and understand their stress.
An Enhanced Methodology for Creating Digital Twins within a Paleontological Museum Using Photogrammetry and Laser Scanning Techniques
Authors: Konstantakis Markos , Trichopoulos Georgios , Aliprantis John , Michalakis Konstantinos , Caridakis George , Thanou Athina , Zafeiropoulos Anastasios , Sklavounou Stamatina , Psarras Christos , Papavassiliou Symeon , Koskeridou Efterpi
Published: August 2023

In recent years, researchers in the field of natural heritage have intensified their efforts to develop new ways to enhance the promotion and accessibility of natural content in order to attract more audiences using virtual representations of physical objects (digital twins). Therefore, they are increasingly incorporating new technologies and digital tools in their operations since their usage by the general public and in the natural heritage (NH) museums is considered particularly effective. Simultaneously, the increasing quality of the produced digitizations has opened up new opportunities for the exploitation of the outcomes of digitization beyond the initial anticipations. Responding to the growing demand of museum visitors for a personalized digital tour experience, especially amidst the recent COVID-19 pandemic, the v-PalM project aims to develop a digital platform to offer virtual guidance and education services at the Museum of Paleontology and Geology, which is hosted at the National Kapodistrian University of Athens. The development of the platform will be based on collecting data through various methods, including crowdsourcing, innovative information, and communication technologies, taking advantage of content digitization using 3D scanning devices. This paper demonstrates an enhanced methodology for the digitization of paleontological exhibits. The methodology uses photogrammetry and laser scanning methods from various devices, such as drones, laser scanners, and smartphones. These methods create digital twins that are suitable for various scenarios, including research, education, and entertainment. The proposed methodology has been applied to over fifty paleontological museum exhibits of varying sizes and complexities, and the resulting 3D models exhibit high accuracy in both their material and geometric aspects, while they also feature crucial details that assist researchers and the scientific community.
Effects of 1-Methylcyclopropene Treatment on the Quality and Malic Acid Metabolism of ‘Xiangjiao’ Plum under Low-Temperature Storage
Authors: Wu Shutong , Zhu Zhiqiang , Han Yunze , Ji Shujuan , Cheng Shunchang , Zhou Qian , Zhou Xin , Li Meilin , Wei Baodong
Published: August 2023

‘Xiangjiao’ plum (Prunus salicina Lindl.) is a stone fruit that is vulnerable to the chilling injury (CI) that is caused by low-temperature stress. The effects of 1-methylcyclopropene (1-MCP) and ethylene absorbent (EA) treatments on the fruit quality and malic acid metabolism of ‘Xiangjiao’ plum stored at 4 °C were compared in this study. Compared with the control check (CK) and EA treatment, fumigation with 1.0 mg·L−1 of 1-MCP for 24 h could more significantly maintain the sensory and physiological quality of the fruit, increase the activity of antioxidant enzymes, and prolong the storage time of plums. Furthermore, 1-MCP treatment can regulate the high expression of the tonoplast dicarboxylate transporter (tDT) and phosphoenolpyruvate carboxylase (PEPC) gene, regulate the high expression of the NAD-malate dehydrogenase (NAD-MDH) gene at the end of storage, and inhibit the expression of the NADP-malic enzyme (NADP-ME) gene. These changes resulted in increased NAD-MDH enzyme activity and decreased NADP-ME enzyme activity, which inhibited the degradation of malic acid that is caused by CI. As a result, 1-MCP can effectively maintain the storage quality of ‘Xiangjiao’ plum, reduce the loss of pleasant sour taste, and improve the edible flavor and commercial value of the fruit.
A Cold Case—Glucosinolate Levels in Kale Cultivars Are Differently Influenced by Cold Temperatures
Authors: Hahn Christoph , Müller Anja , Kuhnert Nikolai , Albach Dirk C.
Published: August 2023

Among the Brassica oleracea L. crops, kale has gained increased global recognition in recent years as a healthy food item due to its high nutritional value and versatility. Additionally, the diversity of different kale varieties has started to be explored across large latitudes from the Mediterranean to north temperate climates. Specifically, glucosinolates are the predominant phytochemicals found in kale leaves, contributing to the specific taste of this vegetable, and they are affected by environmental factors such as temperature. To date, no study has investigated the effect of chilling on glucosinolate diversity and, thus, the taste in genetically different kale cultivars at the same time. Given the variability of glucosinolates observed among cultivars, we evaluated the impact of acclimation to cold temperatures on glucosinolate levels in curly kale, Lacinato kale, and a feral type using high-performance liquid chromatography coupled with time-of-flight mass spectrometry (HPLC-ESI-qTOF-MS). We targeted the short-term impact (after 12 h) on glucosinolates as well as the longer-term effect (after seven days) of cold acclimation. Our results revealed different molecular patterns regarding the change in glucosinolates in the feral type compared to curly kale and Lacinato-type kale. In the latter ones, primary aliphatic glucosinolates were induced (the glucoraphanin in Lacinato kale increased by more than 200%). The indole glucobrassicin was not significantly affected. Conversely, in the feral type the indole glucobrassicin was reduced by 35% after cold acclimation, whereas aliphatic glucosinolates were hardly affected. The results indicate that both genetic and environmental factors are important for the composition of glucosinolate patterns in kale. In conclusion, to obtain plants with an improved nutritional value, considering both temperature and the choice of cultivar is crucial during kale cultivation. Future breeding attempts of kale should also emphasize the cultivar-dependent cold acclimation patterns reported here.
L-Tryptophan-Dependent Auxin-Producing Plant-Growth-Promoting Bacteria Improve Seed Yield and Quality of Carrot by Altering the Umbel Order
Authors: Noor Anam , Ziaf Khurram , Naveed Muhammad , Khan Khuram Shehzad , Ghani Muhammad Awais , Ahmad Iftikhar , Anwar Raheel , Siddiqui Manzer H. , Shakeel Amir , Khan Azeem Iqbal
Published: August 2023

Carrot (Daucus carota L.) seed quality is affected by umbel position due to uneven maturation of carrot seeds produced in different umbel orders. However, keeping this in view, we tested whether seed quality could be improved with the suppression of tertiary umbels under exogenous auxin application. Using auxin-producing bacterial isolates, i.e., Bacillus sp. MN54, Enterobacter sp. MN17, Pantoea sp. MN34, and Burkholderia phytofirmans PsJN, the arrangements of carrot umbel order were evaluated in terms of quality carrot seed production. The results revealed that auxin production by plant-growth-promoting rhizobacteria showed significant differences among measured growth indices, yield, and seed quality attributes. The selected endophytic strains co-applied with auxin via foliar application improved all growth- and yield-related traits, as well as the enzymatic activities of carrots. Noticeably, MN17+L-tryptophan and MN34+L-tryptophan effectively minimized the number of tertiary umbels by increasing the number of secondary umbels. Furthermore, treating with PsJN+L-tryptophan and MN34+L-tryptophan resulted in reduced conductivity of seed leachates and malondialdehyde levels in primary, secondary, and tertiary umbel seeds. These findings collectively indicate the potential of the foliar application of PsJN+L-tryptophan and MN34+L-tryptophan to effectively alter umbel arrangement, leading to improved yield and seed quality. This study implies that carrot seed producers can consider employing specific PGPB strains, particularly MN34+L-tryptophan, to suppress tertiary umbels and achieve higher yields of high-quality carrot seeds.
Assimilating Soil Moisture Information to Improve the Performance of SWAT Hydrological Model
Authors: Kofidou Maria , Gemitzi Alexandra
Published: August 2023

The present work aims to highlight the possibility of improving model performance by assimilating soil moisture information in the calibration and validation process. The Soil and Water Assessment Tool (SWAT) within QGIS, i.e., QSWAT, was used to simulate the hydrological processes within the test basin, i.e., Vosvozis River Basin (VRB) in NE Greece. The model calibration and validation were conducted via SWAT-CUP for a four-year period from 2019 to 2022, in three different ways, i.e., using the traditional calibration process with river flow measurements, using satellite-based soil moisture only in the calibration, and finally incorporating satellite-based soil moisture datasets and calibrating using simultaneously flow and soil moisture information. All modeling approaches used the same set of input data related to topography, land cover, and soil information. This study utilized the recently released global scale daily downscaled soil moisture at 1 km from the Soil Moisture Active Passive (SMAP) mission to generate soil moisture datasets. Two performance indicators were evaluated: Nash Sutcliffe (NS) and coefficient of determination (R2). Results showed that QSWAT successfully simulated river flow in VRB with NS = 0.61 and R2 = 0.69 for the calibration process using river flow measurements at the outlet of VRB. However, comparing satellite-based soil moisture, NS and R2 were considerably lower with an average derived from the 19 subbasins (NS = 0.55, R2 = 0.66), indicating lower performance related to the simulation of soil moisture regime. Subsequently, introducing satellite-derived soil moisture as an additional parameter in the calibration process along with flow improved the acquired average soil moisture results of the 19 subbasins (NS = 0.85, R2 = 0.91), while preserving the satisfactory performance related to flow simulation (NS = 0.57, R2 = 0.66). Our work thus demonstrates how assimilating available satellite-derived soil moisture information into the SWAT model may offer considerable improvement in the description of soil moisture conditions, keeping the satisfactory performance in flow simulation.
The Impact of Podiatric Intervention on the Quality of Life and Pain in Children and Adolescents with Hypermobility
Authors: Maarj Muhammad , Pacey Verity , Tofts Louise , Clapham Matthew , Coda Andrea
Published: August 2023

The purpose of this study was to evaluate the effect of custom-made orthotics on pain, health-related quality of life (HRQoL), function and fatigue in children and adolescents with generalised joint hypermobility (GJH) and lower limb pain. Fifty-three children aged 5–18 years were fitted with custom-made polypropylene orthotics. Visual analogue scale (VAS) assessed lower limb pain severity, Paediatric Quality of Life Inventory assessed HRQoL and fatigue and six-minute walk test (6 MWT) measured functional endurance at baseline, at 1 month and 3 months post-intervention. A mixed model including a random intercept for participant and a fixed effect for time was used to assess differences in outcomes over time. Fifty-two children completed the study (mean age 10.6-years). Children reported significantly reduced pain (mean VAS reduction −27/100, 95%CI: −33, −21), improved HRQoL (mean total improvement 11/100, 95%CI: 7, −15), functional capacity (mean 6MWT improvement 27 m, 95%CI: 18, −36) and fatigue (mean total improvement 13/100, 95%CI: 9, −17) after 1 month of wearing the custom-made orthotics. From 1 month to 3 months there was further statistically but not clinically significant reduction in pain while benefit on other outcomes was maintained. In this study, children with GJH reported reduced lower limb pain, improved HRQoL, functional endurance and fatigue after a month post-fitting of custom-made orthotics which was maintained over a 3 month period. Orthotics were well-tolerated with no serious adverse events reported.
Indocyanine Green (ICG) Fluorescence Is Dependent on Monomer with Planar and Twisted Structures and Inhibited by H-Aggregation
Authors: Chon Bonghwan , Ghann William , Uddin Jamal , Anvari Bahman , Kundra Vikas
Published: August 2023

The optical properties of indocyanine green (ICG) as a near-infrared (NIR) fluorescence dye depend on the nature of the solvent medium and the dye concentration. In the ICG absorption spectra of water, at high concentrations, there were absorption maxima at 700 nm, implying H-aggregates. With ICG dilution, the main absorption peak was at 780 nm, implying monomers. However, in ethanol, the absorption maximum was 780 nm, and the shapes of the absorption spectra were identical regardless of the ICG concentration, indicating that ICG in ethanol exists only as a monomer without H-aggregates. We found that emission was due to the monomer form and decreased with H-aggregate formation. In the fluorescence spectra, the 820 nm emission band was dominant at low concentrations, whereas at high concentrations, we found that the emission peaks were converted to 880 nm, suggesting a new form via the twisted intramolecular charge transfer (TICT) process of ICG. The NIR fluorescence intensity of ICG in ethanol was approximately 12- and 9-times brighter than in water in the NIR-I and -II regions, respectively. We propose an energy diagram of ICG to describe absorptive and emissive transitions through the ICG structures such as the monomer, H-aggregated, and TICT monomer forms.