bluuebunny/crossref_metadata_2025 huggingface dataset:
DISTANCE MEASUREMENTS BASED ON ROAD INFRASTRUCTURE INDICATORS CHARACTERISTICS AFFECTING PURCHASING DECISION OF AFFORDABLE HOUSING IN NORTHERN STATES OF PENINSULAR MALAYSIA
Authors:   Programme of Estate Management, Department of Built Environment Studies and Technology, College of Built Environment Studies Universiti Teknologi Mara, Perak Branch, 32610, Seri Iskandar, Perak, Malaysia, Mohamad @ Masri Muhamad Hilmi , Sa’ad Mohd Farid ,   Programme of Estate Management, Department of Built Environment Studies and Technology, College of Built Environment Studies Universiti Teknologi Mara, Perak Branch, 32610, Seri Iskandar, Perak, Malaysia, Azman Najma ,   Programme of Estate Management, Department of Built Environment Studies and Technology, College of Built Environment Studies Universiti Teknologi Mara, Perak Branch, 32610, Seri Iskandar, Perak, Malaysia, Aliasak Mohd Hasrol Haffiz ,   Programme of Estate Management, Department of Built Environment Studies and Technology, College of Built Environment Studies Universiti Teknologi Mara, Perak Branch, 32610, Seri Iskandar, Perak, Malaysia, Mohd Lazi Mohd Khairul Afzan ,   Geotechnic and Transportation Department, Faculty of Civil Engineering, Universiti Teknologi Malaysia, 81310, Johor Bahru, Johor, Malaysia, Md Wadzir Mohammad Fitry ,   Programme of Estate Management, Department of Built Environment Studies and Technology, College of Built Environment Studies Universiti Teknologi Mara, Perak Branch, 32610, Seri Iskandar, Perak, Malaysia
Published: December 2024

The research is aimed at distance measurements based on road infrastructure indicators characteristics affecting the purchasing decision of affordable housing in northern states of Peninsular Malaysia. The objectives of this research are to measure road infrastructure indicators relating to distance and affordable housing and to analyse the relationship between road infrastructure indicators on distance and affordable housing. Structural Equation Modelling was utilized in this research for analysis and findings whilst discussions conducted on significant level measurement based on each indicator. The significance of the research is to help everyday commuters in making better decision-making processes to purchase affordable houses that they are comfortable with in their daily travels. Affordable houses at a closer rate therefore can contribute significant positive effects on pollution emissions by private vehicles travelling long distances daily thus achieving greener results.
Assessment of Famers` Adaptation Strategies of Climate Variability: Implication on Arable Crops Yield in Ogoja Agricultural Zone (Northern) Cross River State, Nigeria.
Authors:   Geography Unit, School of Arts and Science, University of The Gambia, AKIM  OGAR OKANG , JOSIAH NWABUEZE OBIEFUNA ,   Department of Geography and Environmental Science, University of Calabar-Nigeria, JOY WILLIAM UNDIE ATSA ,   Department of Environmental Resource Management, University of Calabar, Nigeria
Published: December 2024

The study assessed farmers’ adaptation strategies of climate variability and implication on arable crops yield in Ogoja agricultural zone. Data collection procedure adopted for this study was the used of structured questionnaire, interview and focal group discussion. Four hundred copies of questionnaires were administered and three hundred and eighty eight were retrieved. The result revealed that the following adaptation strategies indicated that changing crop types /improved varieties has 70.6 percent negative and 29.4 percent positive respondent, soil and water conservation with 76.3 percent negative and 37.4 percent positive, changing planting time 62.6 percent negative and 37.4 percent positive respondent, cropping mixture or mixed cropping 32.2 percent negative and 67.8 percent positive, supplementary irrigation 55.9 percent negative and 44.1 percent positive respondent, mulching 30.2 percent negative and 69.8 percent positive, planting distance 68.0 percent negative and 32.0 percent positive, regular weeding 69.3 percent negative and 30.7 percent positive, planting trees 30.9 percent negative and 69.1 percent positive respondent ,early planting season with 41.2 percent negative and 58.8 percent positive and late planting season recorded 61.9 percent negative and 38.1 percent positive respondent. Relevant recommendations were made which includes that government should provide access to credit facilities to farmers. Besides crops that have natural adjustment potentials to climate oscillation should be cultivated and promoted. Finally, sustainable indigenous crops species with high yield and low risk as well as environmental education should be adapted.
Pensar en dictadura. Los intelectuales católicos argentinos entre la revolución y la democracia (1976-1983)
Authors: Zanca José
Published: December 2024

Durante el período inmediatamente anterior a la última dictadura argentina (1976-1983), los intelectuales católicos latinoamericanos experimentaron un intenso clima de debate político y teológico. El objetivo de este artículo es analizar las características que adquirió este debate desde 1976 hasta los primeros años de la reinvención democrática de la década de 1980 en Argentina. La singularidad de este período debe analizarse superponiendo varias capas de significado. Por un lado, la situación política en Argentina, marcada por la acción represiva de la dictadura del Proceso de Reorganización Nacional, que apuntó particularmente a líderes cristianos de izquierda. En segundo lugar, el momento de cambio en el liderazgo eclesiástico a nivel latinoamericano y universal, con la llegada de Karol Wojtyła al trono de Pedro. Y por último, pero no menos importante, el debate que giró en torno al concepto de intelectual, que utilizó un nuevo lenguaje para hablar de la política futura, se alejó en gran medida de las premisas revolucionarias de la década de 1970. El artículo utilizará como insumos las intervenciones de una serie de figuras que se convirtieron en referentes argentinos del pensamiento católico- Jorge Mejía, Lucio Gera, Juan Carlos Scannone, Enrique Dussel – y las revistas culturales y teológicas como espacios de debate y encuentro, fuente tradicional en la historia de las ideas y los intelectuales.
How to decline inequality: A taxation study on the luxury goods market
Authors: Lozhnikova Anna , Kichko Natalia , Xu Yeqiang , Ilina Tatiana
Published: December 2024

This article investigates the income and expenditure patterns of individuals, with a specific focus on investments in luxury items, real estate, and expensive modes of transportation. Using global databases such as “Luxury Goods—Worldwide/Statista Market Forecast” and “Data—WID—World Inequality Database”, the authors explore the correlation between high demand for luxury items and economic inequality. The study emphasizes the role of luxury tax as essential for implementing a progressive personal income tax system in Russia. By examining country-specific factors, particularly in China and Russia, and conducting a comparative analysis of progressive tax systems globally, the research highlights the potential of luxury tax to enhance the efficacy of income tax in reducing inequality.
The implementation of ijarah muntahiyah bittamlik in infrastructure project financing within the public-private partnership models: A collaborative governance perspective
Authors: Sulistyowarno Lasarus Bambang , Susamto Akhmad Akbar , Hadna Agus Heruanto , Nurhadi Nurhadi
Published: December 2024

This paper investigates the implementation of ijarah muntahiyah bittamlik (IMBT) as an infrastructure project financing scheme within the Public-Private Partnership (PPP) models from a collaborative governance perspective. This paper follows a case study methodology. It focuses on two Indonesian non-toll road infrastructure projects, i.e., the preservation of the East Sumatra Highway projects, each in South Sumatra province and Riau province. The findings revealed that Indonesia’s infrastructure development priorities and its vision to become a global leader in Islamic finance characterized the system context that shaped the implementation of IMBT as an infrastructure project financing scheme within the PPP-AP model. Key drivers include leadership from the government, stakeholder interdependence, and financial incentives for the partnering business entity to adopt off-balance sheet solutions. Principled engagement, shared motivation, and the capacity for joint action characterized the collaboration dynamics, leading to detailed collaborative actions crucial for implementing IMBT as a financing scheme.
Robust competency-based evaluation matrix for directive PMO services in construction projects
Authors: Ismaeil Esam M. H. , Sobaih Abu Elnasr E.
Published: December 2024

The interest in using project management office (PMO) services in organizations to manage their construction projects is growing in light of rising economic, technological, and social developments based on their ability to achieve organizational goals while avoiding risks. Accordingly, organizations use PMO services to manage their technical and financial project issues to periodically evaluate PMO performance and services in a scientific, practical, and measurable way to ensure successful project path via PMO. Therefore, this research aims to develop a performance evaluation system that enables organizations to follow up and evaluate the PMO performance to ensure that PMO manages the organizations’ expectations and goals successfully according to certain quality, scope, and cost. The study builds on significant findings in PMO competence indexes as evaluation matrix, which includes five basic categories with 136 indexes covering the project life cycle. The matrix was developed based on literature analysis and supplemented with experts’ interviews in construction management. The developed robust competency-based index (RCI) for directive PMO supports the organizations to conduct client satisfaction, correction, or partial/total change of the PMO’s competence flow within five construction project life cycle and process, i.e. governance, portfolio, information, execution, and contract issues.
(In) constitucionalidade na confissão do acordo de não persecução penal regulamentado pela lei 13.964/19
Authors: Ratochinski Gustavo , Ambrosio Felipe Augusto Rodrigues
Published: December 2024

A incorporação do Acordo de Não Persecução Penal (ANPP) ao ordenamento jurídico brasileiro, apesar de se tratar de algo novo, tem gerado uma série de polêmicas. Em virtude de o instituto configurar uma forma de justiça penal negocial, submete-se a alguns princípios norteadores, como o devido processo legal, ampla-defesa e contraditório, presunção de inocência e não autoincriminação. Nesse sentido, o presente artigo analisa uma possível inconstitucionalidade do papel obrigatório da confissão para a celebração do acordo. Primeiramente será abordado os aspectos do acordo, passando pela forma de justiça negocial que o instituto se enquadra, pelo modelo ao qual este foi inspirado e seus requisitos, tendo em foco o da confissão. Prossegue com o estudo aos princípios constitucionais junto à possível infração que o papel obrigatório da confissão possa trazer a estes. E finaliza com uma consideração final a qual aponta contradições e inconsistências em relação aos mecanismos do acordo, visando uma maior necessidade ao aprofundamento nos estudos para que assim o instituto atinja sua máxima efetividade. Além disso, o trabalho se baseia por meio do método estruturalista, com uma abordagem dialética, e enquanto a técnica de pesquisa, documentação bibliográfica e legislativa.
Medidas protetivas de urgência terapêuticas no Planalto Norte Catarinense
Authors: Froggel Esheley , Taporosky Filho Paulo Silas
Published: December 2024

Vigentes em legislação específica desde o ano de 2020, as medidas protetivas de urgência de caráter terapêutico possuem o objetivo de superar, mas sem desconsiderar, o aspecto repressivo que se faz presente nas medidas em geral, intencionando assim um viés que pode ser chamado de terapêutico ao considera que se busca a reeducação e a recuperação do sujeito agressor no cenário da violência doméstica e familiar contra a mulher. Ao levar em conta o fator tempo passado desde quando entraram em vigência na Lei Maria da Penha, surgiu o questionamento sobre a aplicabilidade dessas medidas no âmbito da justiça catarinense na região do planalto norte, de modo que foi com base nessa indagação que o problema de pesquisa foi definido e delimitado, assim se pontuando: as medidas protetivas de urgência terapêuticas têm sido implementadas e aplicadas pela justiça catarinense? O objetivo da pesquisa se pautou pelo levantamento em determinadas comarcas catarinenses (Mafra, Papanduva, Porto União e Canoinhas) de informações ou dados sobre a aplicabilidade das medidas protetivas de urgência de caráter terapêutico nos fóruns desde que entraram em vigor na Lei Maria da Penha. A metodologia empregada é a exploratória de revisão bibliográfica. Os resultados obtidos se deram no sentido de confirmar a hipótese negativa da pesquisa, tendo em vista que na maioria das comarcas não se tem aplicado as medidas terapêuticas. A conclusão se dá no sentido de apontar para a necessidade de adoção de políticas públicas para além da legislação temática, pois somente com programas específicos implementados nas comarcas é que se faz possível a adoção das medidas terapêuticas em decisões judiciais.
Generation of primary feline chimeric antigen receptor T cells
Authors: Cockey James R. , Zhou Gavin M. , Kulp Emily N. , Urbina Christian A. , Kerkenpaß Christina , Leifer Cynthia A.
Published: December 2024

OBJECTIVE

The purpose of this study was to develop procedures to engineer feline chimeric antigen receptor (CAR) T cells.

METHODS

6 healthy cats were used in this study. Blood was collected, and CD3+ primary T cells were enriched by magnetic activated cell sorting, expanded, and used to generate CAR T cells.

RESULTS

Phorbol myristate acetate plus ionomycin and concanavalin A induced similar early proliferation of CD3-enriched feline CD4+ and CD8+ T cells but phorbol myristate acetate plus ionomycin induced greater expansion over 12 days. Chimeric antigen receptor T cells were engineered by transduction with an FIV-based lentiviral system to express a human CD19 CAR. Feline CD19 CAR T cells demonstrated specific cytotoxicity against human CD19+ target cells. Conditions were developed to polarize the T cells to THelper subsets.

CONCLUSIONS

We generated functional and specific primary feline CAR T cells and demonstrated conditions to polarize the cells, which may be therapeutically advantageous for CAR T-cell use in a variety of disease contexts.

CLINICAL RELEVANCE

CAR T therapy has been used with great success for human hematologic malignancies and is under development for use in canines. Our study is the first demonstration of functional feline CAR T cells and describes the procedures for their engineering. These findings lay the foundation for future development of CAR T therapy for multiple feline diseases.
Bovine Lung Peptides after Trypsinolysis Reveal Anti-Exudative Activity
Authors: Ishimov U. J. , Gafurova N. , Asrorov A. M. , Wali A. , Mukhamedov N. , Olimjonov S. O. , Vypova N. , Khamidov S. , Abdirahimova S. Sh. , Ziyavitdinov J. F.
Published: December 2024

Enzymatic hydrolysates of proteins isolated from cow lungs are used as anti-inflammatory agents for the growth and regeneration of new tissues. Hydrolysates were observed to inhibit the production of free radicals in cells and have a high anti-exudative activity even in low doses. In this study, we established the anti-exudative activity of peptides of protein hydrolysates isolated from bovine lungs. The anti-exudative activity of the peptides sum was compared with acetylsalicylic acid (ASA) and prednisolone, and the dynamics of inflammation were studied by tumour formation using carrageenan and formalin. Between 1 h and 24 h after administration of the drug, the effect of the peptides sum showed a significantly better indicator than the rest of the means. In general, the anti-exudative activity of the peptides sum was 2–3 times higher than the rest of the preparations. Biochemical indicators of prednisolone and peptides sum in two doses of 10−6 μg/kg and 10−4 μg/kg were studied. As a result of the study, it was found that the peptides sum at 10−6 μg/kg dose enhanced alanine aminotransferase (ALT) activity by 17.1% compared to those resulting from prednisolone treatment. In C-reactive protein (CRP) and antistreptolysin O (ASO) indicators, 10−4 μg/kg dose showed high activity. The sum of isolated peptides reduced ALT and ASO levels. This study provides additional support for preparing anti-inflammatory means from the peptides sum isolated from bovine lungs.
Being and Experiencing: Jamasan Tombak Kyai Upas Sebagai Ritual Warisan Mataram Yogyakarta di Kabupaten Tulungagung dalam Perspektif David N. Elkins
Authors: Santosa Bagus , Lestari Sri , Sulistyo Hary , Indianto S Dimas
Published: December 2024

This study examines the Jamasan Kyai Upas ritual, a Mataram Yogyakarta heritage still practiced by the Tulungagung community. While traditionally associated with the Yogyakarta Sultanate, the Kyai Upas spear, a symbolic heirloom of Tulungagung, remains a significant cultural element. The study explores the ritual’s historical continuity, its symbolic meaning, and the community’s beliefs surrounding the heirloom. Using a qualitative ethnographic approach, this research employs Elkins’ (1998) theory of spirituality, which emphasizes being and experiencing as awareness of transcendence and core values in life. Data was collected through interviews to link cultural beliefs (being) and experiences (experiencing) with the ritual. Findings reveal that (1) the Kyai Upas spear connects Tulungagung’s identity with the Yogyakarta Sultanate and (2) the spear symbolizes good fortune and safety for the Tulungagung community, grounded in historical and contemporary contexts.
Coordenadoras pedagógicas iniciantes: a formação e os desafios da função no Maranhão
Authors: Diniz Camila Castro , Moraes Lélia Cristina Silveira de
Published: December 2024

Este artigo busca analisar a formação e os desafios existentes na mudança da função de professora para a de coordenadora pedagógica, no Maranhão. Tomamos como referência algumas constatações extraídas de uma pesquisa de Mestrado[1], de natureza qualitativa e exploratória, pautada no método histórico-dialético, concluída no ano de 2018. O aporte teórico teve a contribuição de: Lima (2017); Melo (2015), entre outros. Os achados desse estudo, que recorreu a entrevistas semiestruturadas realizada com três coordenadoras pedagógicas, de Rosário e Santa Inês, no Maranhão, apontam que, quando iniciantes, além de questões burocráticas e emergenciais estas coordenadoras enfrentaram outros desafios, como: ausência de formação específica, falta de autonomia e relacionamento interpessoal. Concluímos que mais políticas de apoio e de valorização devem ser construídas para que a identidade e prática destes profissionais sejam consolidadas nas escolas
[1] Mestrado em Educação, do Programa de Pós- Graduação em Educação, da Universidade Federal do Maranhão (PPGE- UFMA).
Exploring user perceptions: The impact of ChatGPT on high school students' physics understanding and learning
Authors: Fadillah Muhammad Aizri , Usmeldi Usmeldi , Lufri Lufri , Mawardi Mawardi , Festiyed Festiyed
Published: December 2024

Artificial intelligence (AI) in education is increasing, including ChatGPT as a learning tool in physics subjects. This study aims to analyze high school students' perceptions of using ChatGPT in physics learning, focusing on demographic factors such as gender, academic level, and duration of use. Involving 167 students, the study used a survey to evaluate students' views on various aspects of the learning experience with ChatGPT, including effectiveness, clarity, consistency of information, and the tool's ability to enrich understanding of physics concepts. Results showed that students' perceptions were positive overall, with ChatGPT perceived as helping to deepen concept understanding, improving the ability to correct misconceptions, and providing an enjoyable learning experience. Significant differences were found based on gender and academic level, while the duration of ChatGPT use showed no overall significant effect, though longer use enhanced specific benefits. These findings highlight the potential of ChatGPT to support physics education by addressing students' diverse needs and improving learning outcomes, offering insights for educators in integrating AI tools effectively into classrooms.
O MODELO DE DECISÕES APOIADAS EM INTELIGÊNCIA ARTIFICIAL PARA O EXERCÍCIO DO CONTROLE EXTERNO PELOS TRIBUNAIS DE CONTAS
Authors: Barros Herbert Correa , Destro Carla Roberta Ferreira
Published: December 2024

Este trabalho aborda a aplicação da inteligência artificial (IA) no controle externo exercido pelos Tribunais de Contas brasileiros, a fim de automatizar rotinas e aprimorar a fiscalização dos entes e órgãos fiscalizados. No entanto, a adoção dessas ferramentas enfrenta desafios como a modificação de rotinas administrativas internas, o treinamento e qualificação de servidores, bem como a necessidade de investimentos constantes. O propósito do texto é diagnosticar vantagens e desafios para a implementação dessa tecnologia, bem como sustentar o modelo de decisões apoiadas em inteligência artificial, a fim de preservar a supervisão e a decisão humana. O texto defende que a implementação da IA está em sintonia com o princípio da eficiência e poderá trazer maior celeridade e assertividade para o controle externo. Adota-se uma metodologia hipotético-dedutiva, com a pesquisa bibliográfica em livros, periódicos, bem como em sites institucionais dos Tribunais de Contas brasileiros. Por fim, o artigo conclui ao ressaltar a necessidade de uma abordagem cautelosa na aplicação da IA, que, embora ela tenha o potencial de tornar a atividade fiscalizatória mais eficiente, é fundamental que a decisão final seja tomada por profissionais experientes e qualificados, levando em consideração a complexidade das questões jurídicas e sociais envolvidas.
The cyclic vector of realization of cultural memory in the novel "Chagin" by Evgeny Vodolazkin
Authors: Bezrukov Andrey Nikolaevich
Published: December 2024

Evgeny Vodolazkin has firmly established himself in the latest Russian prose as a master of the realization of artistic intrigue. His novels are a vivid confirmation of this. The writer, in addition to forming a very dense intriguing plot, adding a figurative series, manifesting a point of view, deliberately uses the technique of artistic collision, but in an admittedly realistic way. For Evgeny Vodolazkin, the course of novel events is not only a literal combination of situational episodes, it is also a carefully thought-out dialogue with the reader. The subject of the research in the article is the deciphering of the theme of memory on the example of E.G. Vodolazkin's novel "Chagin". The object of study correlates with the main issue of the text, which builds a narrative, a figurative series, a genre structure. The purpose of the work is a parametric analysis of the manifestation of cultural memory in the specified text. The assessment of the imaginative thinking of the main character, Isidor Chagin, is not excluded in the study, since memory cannot be considered separately from the feeling and perception of reality by the character. The methodological basis of the work is focused on the comparative principles of text evaluation, conceptual verification of the work, taking into account the systematization of receptive connotations. In the novel "Chagin", the main character is going through a crisis state – he cannot forget what he has read, seen, and experienced. Memory is syncretically soldered to the existence of the hero as such, it ontologically sets the metaphysics of the character's existence. The scientific novelty of the study lies in the fact that the novel has not yet been practically studied within the framework of this category, there is no proper assessment of the topic in the critical-analytical type mode. The materials can be useful practically in verifying the style, manner of writing, and artistic thinking of Evgeny Vodolazkin. The conclusions of the work are focused on the fact that memory in the novel "Chagin" is a formula of irreversibility. But the actions and deeds of the hero are in many ways a demonstration of multiplicity. Although Vodolazkin's writing style and poetics do not gravitate towards postmodernism, the influence of modern trends is clearly evident in this work. The plot of the novel is not accidental, the figure of the main character is composed in a special way, but the context itself, clearly expanding, has a multiplicity of excuses. Cultural memory is cyclically oriented, for Evgeny Vodolazkin it is an impulse to destabilize meanings, because it is an ontological task of artistic creation.
The The relationship between injury severity, grip strength and functionality in traumatic hand injuries
Authors: Duman Şahin Zehra , AYYILDIZ Aylin , Çiftci İnceoğlu Selda , Kuran Banu
Published: December 2024

Purpose: This study aimed to investigate the relationship between injury severity and functionality in traumatic hand injuries.Methods: Forty-four patients with traumatic injuries to the hand were included. Patients who were grouped as minor, moderate, and severe-major by Modified Hand Injury Severity Score (mHISS) score, were evaluated with grip strength, lateral grip strength, and Sollerman Hand Function Test (SHFT) at the 4th and 12th weeks. Among the functional scales, The Disabilities of the Arm, Shoulder and Hand questionnaire (DASH) and the Patient-Rated Hand and Wrist Evaluation (PRWHE), Health Assessment Questionnaire (HAQ) were used.Results: According to the patients’ total mHISS score, 27.2% were classified as having minor injuries, 43.1% as having moderate injuries, and 29.4% as having serious-major injuries. The first 4 weeks of the rehabilitation period showed a statistically significant increase in both grip strength and SHFT scores. Furthermore, grip strength and SHFT scores were significantly lower across all mHISS groups, with greater reductions observed in the group with more severe injuries. A significant positive correlation was observed between the total mHISS score and PRWHE, DASH, and HAQ scores in all follow-ups. As the severity score increased, functionality worsened.Conclusion: Assessing the severity of injury and functionality in these patients allows for effective management of treatment and rehabilitation, ultimately improving their functional status and general health.
Intervención en salud sexual y reproductiva en mujeres privadas de libertad de Uruguay
Authors: Ben Sebastian , Fiol Verónica , Viroga Stephanie , Tarigo Josefina , Arribeltz Gualberto , Briozzo Leonel
Published: December 2024

En mujeres privadas de libertad de Uruguay existe un déficit asistencial en Salud Sexual y Reproductiva. El objetivo del estudio es mejorar el ejercicio de los Derechos Sexuales y Reproductivos en mujeres privadas de libertad, brindando acceso a servicios ginecológicos integrales dentro de las cárceles.Estudio descriptivo retrospectivo, se incluyeron todas las mujeres privadas de libertad en cárceles uruguayas. La intervención consistió en una consulta clínica ginecológica integral, se abordaron aspectos de salud sexual y reproductiva con diagnóstico y tratamiento. Las consultas se realizaron en cárceles de Montevideo e interior.
Se realizó la consulta clínica a 513 mujeres privadas de libertad (83% del total) en 800hs de atención médica y 640hs de gestión, con participación de 52 profesionales médicos. Se realizaron 401 colpocitologías oncológicas, 74 patológicas (18%). Se realizaron 108 Test Virus Papiloma Humano, 16 positivos para Alto Riesgo oncogénico (14%). Se realizaron 103 colposcopías y detectando 11 lesiones escamosas de alto grado, realizándose tratamiento quirúrgico. En anticoncepción se realizaron acciones específicas en 166 pacientes: 55 implantes subdérmicos; 27 Dispositivos Intrauterinos, 62 anticonceptivos orales y 23 inyectables. En 61 mujeres se brindaron preservativos masculinos y femeninos.Se desarrolló una intervención en salud sexual y reproductiva al 83% de las mujeres privadas de libertad de Uruguay con especial abordaje en prevención del cancer genitomamario y anticoncepción. Puede ser un insumo para el desarrollo de políticas públicas en esta población.
Eventos adversos de la vacuna contra SARS-CoV-2 en una muestra pediátrica uruguaya
Authors: Trujillo Janet , Correa Matías , Madamo Agustina , Alvarez Cecilia Beatriz , Pintos Javier , Aguirrezábal Patricia , Inthamoussu Maite , Speranza Noelia , Pujadas Mónica , Alemán Alicia
Published: December 2024

En nuestro país, se recomendó el uso de la vacuna Pfizer/BioNTech en niños/as de 5 y 11 años desde diciembre/2021, en dos dosis separadas por seis semanas. Es necesario una mayor valoración de la vacuna debido a su rápido proceso de aprobación.El objetivo del estudio fue determinar la ocurrencia de eventos supuestamente atribuibles a la vacunación e inmunización (ESAVI) contra SARS-CoV-2 en niños/as de 5 y 11 años.Se realizó un estudio descriptivo. Se incluyeron niños/as menores de 12 años con exámenes de sangre por indicación médica en el laboratorio del Centro Hospitalario Pereira Rossell entre noviembre de 2021/2022. Fueron colectados datos de: ESAVI, estado vacunal, edad y sexo mediante encuesta e historia clínica. Las variables se analizaron por estadística descriptiva.Participaron del estudio 141 niños/as entre 5 y menores de 12 años, de estos, un 53,9% (n=74) recibieron la vacuna. Su edad media fue 8,4 (2,1) años y 47,3% eran de sexo femenino. Los ESAVI más frecuentes tras la primera dosis fueron: malestar general (n=8) y cefalea (n=9). En la zona de vacunación fueron: dolor (n=30) y endurecimiento (n=10). En la segunda dosis, los más frecuentes fueron: cefalea y fiebre (n= 3) y los locales fueron: dolor (n=13) y endurecimiento (n=4). Estos síntomas se presentaron más frecuentemente en los primeros tres días post-vacunación en ambas dosis.Estos resultados nos permiten concluir que los ESAVI encontrados fueron leves, más frecuentemente locales y en un periodo corto post-vacunación.
Use of ionized plasma jet therapy in the treatment of xanthelasma palpebrarum
Authors: Thobde Mallika , Borkar Milind , Oke Manjiri Abhijit , Dodeja Ajay
Published: December 2024

Objectives:

To evaluate the safety and efficacy of ionized plasma therapy for the treatment of xanthelasma palpebrarum.

Material and Methods:

A total of 35 patients were enrolled for the study. Patients were screened as per the predefined inclusion and exclusion criteria. The patients were treated with ionized plasma jet therapy (IPJT) plasma machines. Pre- and post-sizes of the xanthelasma lesions were noted along with the side effects, and the patients were followed up for a period of 90 days.

Results:

The complete resolution of the xanthelasma lesion was observed in 28 out of 35 patients, with two patients requiring two sessions, five patients developing hypopigmentation, and 1 patient having hyperpigmentation as a side effect, which was resolved after 4 weeks.

Conclusions:

Based on the results, ionized plasma therapy for xanthelasma palpebrarum can be recommended as a safe and effective option.
Efektivitas Teknik Self-Instruction Untuk Meningkatkan Kepercayaan Diri Pada Santri
Authors: Putri Navion Febranti , Khasanah Zakiyah
Published: December 2024

Penelitian ini bertujuan untuk mengetahui sejauh mana keefektifan teknik self instruction untuk meningkatkan kepercayaan diri pada santri Pondok Pesantren Mambaus Sholihin 2 Blitar. Pelaksanaan kegiatan dilakukan melalui pemberian konseling individu dengan mendukung adanya perubahan kepercayaan diri santri yang rendah menjadi kepercayaan diri yang lebih tinggi dengan ditandai yaitu cara berfikir yang lebih positif, berani mengambil keputusan dan optimis dalam menjalankan kewajiban. Dalam penelitian ini, metode eksperimen subjek tunggal diterapkan dalam bentuk single subject research (SSR) dalam desain A-B-A. Pada kondisi baseline 1 (A1) dilakukan sebanyak 3 kali pertemuan dengan mean skor 136, pada kondisi intervensi (B) sebanyak 4 kali pertemuan dengan mean skor 172 dan pada fase baseline 2 (A2) dilakukan 3 kali dengan mean skor 199. Pemberian teknik self-instruction terbukti mampu untuk meningkatkan kepercayaan diri santri. Dari uji N-Gain Score didapatkan skor 0,52 atau 52%, sehinggaÂ dapat disimpulkan bahwa teknik self instruction cukup efektif untuk meningkatkan kepercayaan diri padaÂ santri.
Surgical treatment of patients with coronary heart disease in combination with methods of extracardial myocardial vascularization
Authors:   St. George thoracic and cardiovascular surgery clinic Pirogov National Medical and Surgical Center, Moscow, Shevchenko Yu.L. , Borshchev G.G. ,   St. George thoracic and cardiovascular surgery clinic Pirogov National Medical and Surgical Center, Moscow, Miminoshvili L.G. ,   St. George thoracic and cardiovascular surgery clinic Pirogov National Medical and Surgical Center, Moscow
Published: December 2024

Over the years, surgical treatment techniques for patients with coronary heart disease (CHD) have undergone changes. This literature review examines the relevance of surgical treatments, the history of the development of methods for stimulating extracardiac blood supply, and the cell technologies used in patients with coronary artery disease. Particular attention is paid to the development of a surgical and biotechnological technique called «YurLeon», developed by academician Y.L. Shevchenko. Early intervention methods have become relevant due to the rapid development of cellular technologies, allowing for significant improvement and expansion of methods for stimulating vasculogenesis.
Hybrid approach of revascularisation for chronic critical limb ischemia
Authors:   Municipal Сlinical Hospital №15 named O.M. Filatov, Moscow, Maytesyan D.A. ,   Pirogov Russian National Research Medical University, Moscow, Khazamov Sh.A. ,   Municipal Сlinical Hospital №15 named O.M. Filatov, Moscow, Papoyan S.A. ,   Pirogov Russian National Research Medical University, Moscow,   Municipal Сlinical Hospital named F.I. Inozemtsev, Moscow,   Research Institute of Health Care Organization and Medical Management, Moscow, Shchegolev A.A. ,   Pirogov Russian National Research Medical University, Moscow,   Municipal Сlinical Hospital named F.I. Inozemtsev, Moscow, Mzokov H.T. ,   Municipal Сlinical Hospital №15 named O.M. Filatov, Moscow
Published: December 2024

Treatment of patients with atherosclerosis of the lower limbs with an outcome in critical ischemia despite the achievements of modern medicine is a complex process. Critical limb ischemia (CLI) is often accompanied by multi-level artery lesions, which necessitates complex multi-storey arterial reconstructions to rescue limbs. The results of open and endovascular operations are not always optimal. Hybrid Interventions allow you to instantly restore blood flow in several segments, increasing the chances of limb recovery and reducing surgical risks in somatic heavy patients. This overview article presents a comparative analysis of hybrid interventions in patients with critical lower limb ischemia with an emphasis on multi-level artery lesions.
Global risk factors for morbidity among students: decreased physical activity and sedentary lifestyle
Authors:   «State University of Education», Moscow region, Mytishchi, Pivovarova O.A. ,   «National Research Institute of Public Health named after N.A. Semashko» Moscow, Kulikov D.A. ,   «State University of Education», Moscow region, Mytishchi,   «National Research Institute of Public Health named after N.A. Semashko» Moscow, Konyaeva O.E. ,   Pirogov National Medical and Surgical Center, Moscow, Borshchev G.G. ,   Pirogov National Medical and Surgical Center, Moscow, Oleynikova V.S. ,   «State University of Education», Moscow region, Mytishchi
Published: December 2024

The article discusses the issues of reducing the physical activity of students. Statistical studies by domestic and foreign authors on the causes of physical inactivity among students in higher educational institutions, the risks of diseases as a result of a sedentary lifestyle and ways to overcome it are analyzed.
Surgical treatment of a large extracranial aneurysm of the internal carotid artery
Authors:   City Hospital Korolev, Korolev, Sukhareva T.V. , Batrashov V.A. ,   Pirogov National Medical and Surgical Center, Moscow, Morozov K.M. ,   MMS Clinic, Moscow, Yudaev S.S. ,   Pirogov National Medical and Surgical Center, Moscow, Zakurdaev I.A. ,   City Hospital Krasnogorsk, Krasnogorsk, Zabaznov K.G. ,   Rostov State Medical University, Rostov-on-don
Published: December 2024

A case of ICA aneurysm is presented, all possible pathogenesis mechanisms that led to the formation of an aneurysm are analyzed. In the analysis of the clinical case, mathematical modeling confirmed the assumption of the relationship between biomechanical conditions in the aneurysm area, regardless of etiology.
Application of endovascular and hybrid techniques of surgical treatment of traumatic gunshot arteriovenous fistulas of the extremities
Authors:   Main military clinical hospital named after N.N.Burdenko, Moscow, Petrov K.Yu. , Zamskij K.S. ,   Main military clinical hospital named after N.N.Burdenko, Moscow, Gajdukov A.V. ,   Main military clinical hospital named after N.N.Burdenko, Moscow, Pecherskaya M.S. ,   Main military clinical hospital named after N.N.Burdenko, Moscow, Kranin D.L. ,   Main military clinical hospital named after N.N.Burdenko, Moscow, Zaslavskaya M.A. ,   Main military clinical hospital named after N.N.Burdenko, Moscow, Golovushkina G.V. ,   Main military clinical hospital named after N.N.Burdenko, Moscow
Published: December 2024

There is an increase in the number of victims with damage of the main arteries due to the escalation of armed conflicts.

The frequency of vascular injuries varies from 2–3% in peacetime and increases in war up to 6–17%.

The outcome of all cases of vascular injuries in 48.9% to 68.7% is the formation of traumatic arteriovenous fistulas (AVF) and false aneurysms.

This article describes clinical cases of successful treatment of traumatic (gunshot) arteriovenous fistulas of the extremities using endovascular technologies and hybrid techniques.
Multidisciplinary strategy for the treatment of mine blast injury of the forearm
Authors:   Pirogov National Medical and Surgical Center, Moscow, Anankin A.A. , Kinzyagulov B.R. ,   Pirogov National Medical and Surgical Center, Moscow, Ratush S.V. ,   Hospital «Bavaria reha», Moscow, Kondratiev I.A. ,   Pirogov National Medical and Surgical Center, Moscow, Semenov A.H. ,   Pirogov National Medical and Surgical Center, Moscow, Gavrilchenko V.S. ,   Pirogov National Medical and Surgical Center, Moscow, Ivanova A.O. ,   Pirogov National Medical and Surgical Center, Moscow, Chernyshev R.S. ,   Pirogov National Medical and Surgical Center, Moscow, Dzhojua A.V. ,   Pirogov National Medical and Surgical Center, Moscow
Published: December 2024

Mine blast injuries of the upper limb are difficult to classify, which makes every reconstructive surgery after such injuries unpredictable. A clinical observation of a 24-year-old patient who was wounded in the left forearm by a shell fragment is presented. After a complete diagnosis, surgical intervention was performed in the volume — transposition of m. brachioradialis to the common extensors of the fingers, tendon plasty of the radial extensors of the hand. Neurolysis of the median nerve. Due to the lack of standard algorithms for the treatment of such injuries, even careful preoperative planning cannot guarantee a favorable outcome. We are deeply convinced that such reconstructive interventions need a multidisciplinary strategy, and also need high technological support of the operation theater.
Diagnosis and treatment of diverticular colon disease complicated by fistula formation
Authors:   Pirogov National Medical and Surgical Center, Moscow, Levchuk A.L. , Abdullaev A.E. ,   GKB SMP, Vladimir
Published: December 2024

Objective. To improve the results of surgical treatment of patients with urogenital-colonic, small-colonic and large-intestinal-vaginal fistulas of diverticular origin by improving the diagnostic program and surgical tactics.

Materials and methods. A study was conducted with the participation of 82 patients treated at the State Clinical Hospital in Vladimir from 2012-2022 with DPC complicated by the formation of fistulas. There were 38 (46.3%) patients with internal intestinal fistulas, of which 22 (57.9%) were men and 16 (42.1%) were women. The mandatory diagnostic program included: general clinical studies, ultrasound of the abdominal cavity, pelvis, in women transvaginal ultrasound, CT of the abdominal cavity with intravenous contrast enhancement and MRI of the pelvis, cystoscopy, FCS, irrigography, including simultaneous fistulography through an external fistula opening.

Results. The clinical picture of a colovesical fistula was found in 19 (50%) cases, sigmo-vaginal in 14 (36.8%), and ileo-sigmoid in 5 (13.2%) cases. Abdominal ultrasound was performed in all patients (n-82), transvaginal ultrasound in 23 (28%), and ultrasound in 38 (46.3). Irrigoscopy was performed in 68 (82.9%) patients. Cystoscopy was performed in 19 (23.2%) cases. FCS was performed in 68 (82.9%) patients. MSCT in 77 (93.9%) cases. Dissection of the fistula, resection of the sigmoid colon according to Hartmann with the removal of a single-stem colostomy with planar resection and suturing of the bladder wall was performed in 6 (7.3%) patients. LGE was performed in 28 (34.1%) patients. Sigmoid colon resection with primary colonic anastomosis and the imposition of an interventional colostomy was performed in 9 (11%) patients. In 23 (28%) cases, sigmoid colon resection was performed with primary anastomosis without removal of the interventional stoma, in 10 (12.2%) patients with external intestinal fistulas, and 13 (15.9%) with sigmovesical fistula. In 5 (6.1%) cases, resection of the sigmoid colon was performed with resection of the small intestine bearing the fistula, with the imposition of small and large intestinal anastomoses. Complications occurred in 6 (7.3%) cases (Table 5).

Conclusion: The treatment of diverticular colon disease complicated by the formation of fistulas is one of the most urgent and time-consuming tasks. The incidence of this complication is 15.7%. The most severe category of patients are patients with external colon fistulas, since their occurrence was facilitated by previous surgical interventions for complications of DBTC. The only radical method of treatment for this category of patients is only surgical intervention. Given the need to involve related specialists in the treatment of internal DBTC fistulas, the strategy for the diagnosis and treatment of this difficult category of patients should be multidisciplinary. And the method of performing surgical intervention in this case should be strictly personalized.
Dynamics of cellular immunity indicators in patients with parallel pelvic injuries
Authors:   Saratov State Medical University named after V.I. Razumovsky, Saratov, Maslyakov V.V. ,   Private institution educational organization of higher education «Medical University «Reaviz», Salov I.A. ,   Saratov State Medical University named after V.I. Razumovsky, Saratov, Kapralov S.V. ,   Saratov State Medical University named after V.I. Razumovsky, Saratov, Parshin A.V. ,   Saratov State Medical University named after V.I. Razumovsky, Saratov, Dralina O.I. ,   Private institution educational organization of higher education «Medical University «Reaviz», Barsukov V.G. ,   Private institution educational organization of higher education «Medical University «Reaviz», Polidanov M.A. ,   Private institution educational organization of higher education «Medical University «Reaviz»
Published: December 2024

Goal. To study changes in cellular immunity indicators in patients with penetrating gunshot wounds of the pelvis in the immediate postoperative period.

Materials and methods. The study included 40 female patients from the civilian population who were treated for penetrating gunshot wounds of the pelvis received as a result of local hostilities. All patients were female, the average age was 36±4 years. Two clinical groups were formed. In the first (A), the wounded were selected in the number of 20 (50%) people, whose time interval did not exceed 60 minutes, in the second (B) — 20 (50%) wounded, whose time interval exceeded 60 minutes. To achieve this goal, a study of laboratory parameters characterizing cellular immunity was conducted: the total number of leukocytes in peripheral blood, lymphocytes (%), determining changes in subpopulations of both T-lymphocytes and B-lymphocytes. The number of mature T lymphocytes (CD3+); T helper cells (CD4+); cytotoxic T cells (CD8+); natural killers (CD16+); B cells (CD20+) was calculated.

Results. As a result of the study, it was found that changes in the cellular link of the immune system in gunshot wounds of the pelvis depend on the time elapsed from the moment of injury to the beginning of surgical intervention. At the same time, if surgical intervention was performed up to one hour from the moment of injury, changes in the subjects occurred later and recovered earlier compared to the group of wounded who underwent surgical intervention later than one hour from the moment of injury.
The importance of determining the viable myocardium in the patients with chd and diffuse lesion of coronary arteries
Authors:   Pirogov National Medical and Surgical Center, Moscow, Shevchenko Yu.L. , Borshchev G.G. ,   Pirogov National Medical and Surgical Center, Moscow, Vahromeeva M.N. ,   Pirogov National Medical and Surgical Center, Moscow, Vahrameeva A.Yu. ,   Pirogov National Medical and Surgical Center, Moscow, Ulbashev D.S. ,   Pirogov National Medical and Surgical Center, Moscow, Ermakov D.Yu. ,   Pirogov National Medical and Surgical Center, Moscow
Published: December 2024

Coronary heart disease is currently one of the main causes of mortality, temporary and permanent disability of the population in the developed countries of the world. The problem of treating such patients is currently aggravated by an increase in cases of detection of diffuse lesions of the coronary bed, when the usual tactics of complete direct revascularization becomes impossible. In this regard, the attention of cardiac surgeons is directed to the development of new treatment methods. In such conditions, the issue of preoperative diagnosis of the viable myocardium becomes especially relevant, which can significantly affect the choice of surgery tactics aimed at the complete restoration of myocardial perfusion of the left ventricle.