bluuebunny/crossref_metadata_2025 huggingface dataset:
Silica-coated magnetic Fe3O4 nanoparticles as efficient nano-adsorbents for the improvement of the vapor-phase adsorption of benzene
Authors: ECE Mehmet Şakir , KUTLUAY Sinan , ŞAHİN Ömer
Published: June 2021

This study focused on the synthesis of silica-coated magnetic Fe3O4 (Fe3O4@SiO2) nanoparticles and their application for the improvement of the vapor-phase adsorption of benzene. The magnetic Fe3O4@SiO2 nanoparticles were synthesized according to the co-precipitation method, while their characterization was performed using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and Brunauer-Emmett-Teller (BET) surface area analyses. The experimental parameters were optimized to achieve the maximum adsorption capacity for the vapor-phase benzene by Box-Behnken design (BBD) under response surface methodology (RSM). The magnetic Fe3O4@SiO2 nanoparticles adsorbed 197.50 mg/g of the vapor-phase benzene under the following optimum conditions: 39.48 min residence time, 14.21 ppm initial benzene concentration and 26.51°C temperature. The Langmuir, Freundlich and Dubinin-Radushkevich (D-R) models were used to evaluate the adsorption equilibrium data, and the results were found to be well fitted to the D-R model. The kinetic data obeyed the pseudo-second-order kinetic model for the vapor-phase adsorption of benzene by magnetic Fe3O4@SiO2 nanoparticles. This study demonstrated the application potential of magnetic Fe3O4@SiO2 nanoparticles as promising low-cost nano-adsorbents for the vapor-phase adsorption of benzene.
ІНФОРМАЦІЙНО-ЕКОНОМІЧНА БЕЗПЕКА ЯК ФАКТОР СТАБІЛЬНОГО РОЗВИТКУ ДЕРЖАВИ
Authors: Гнатенко Валерій
Published: June 2021

Розкрито сутність поняття “інформаційно-економічна безпека” та її роль у забезпеченні стабільного розвитку держави. Економіка інформаційного суспільства (або інформаційна економіка) орієнтована на стрімке зростання інформаційних ресурсів, і не може розвиватися без широкого використання інформаційно-комунікаційних технологій. Суб’єкти ринкової економіки здійснюють свою діяльність в умовах, коли інформація, інформаційні взаємовідносини, тай взагалі, всі основні складові процесу інформатизації набувають все більшої значущості. Тому комплексна інформаційна безпека виступає запорукою забезпечення економічної безпеки. Вони органічно доповнюють одна одну і нерозривно пов’язані не тільки з практичної точки зору, але і в понятійному відношенні. Запропоновано розглядати в комплексі інформаційну компоненту економічної безпеки й економічний аспект інформаційної безпеки в якості єдиної сфери діяльності, що забезпечує безпеку в управлінській, енергетичній, фінансовій, техніко-виробничій, технологічній та інших областях, що мають істотний вплив на національну безпеку та забезпечують стабільний розвиток держави. Приведене визначення інформаційно-економічної безпеки: комплексна система, що забезпечує захист життєво важливих інтересів громадян, су- спільства та держави в економічній сфері від внутрішніх і зовнішніх інформаційних загроз. Останні в такому визначенні набувають статусу інформа- ційно-економічних загроз — сукупності умов, факторів і подій, що визначає ефективність внутрішніх і зовнішніх деструктивних інформаційних впливів на економічний стан країни, тим самим створюючи небезпеку економічно важливим інтересам особистості, суспільства і держави. Запропоновано сформувати нову міждисциплінарну галузь наукових знань, основним призначенням якої буде розробка шляхів і способів використання інформаційного середовища для вирішення завдань економічної безпеки. Теорія інформаційно-економічної безпеки має охоплювати не тільки опис інформаційних взаємовідносин в економіці, а й їх взаємозв’язок із національною безпекою.
Proposta De Implementação Propor Melhorias No Setor De Marketing: Estudo De Caso Na Empresa Tucuxi Radio Taxi
Authors: Martins Raissa Nayte Soares , Silva Mikaelle Alves da , Silva Felipe Henrique Gomes da , Almeida Victor da Silva , Roberto José Carlos Alves
Published: June 2021

O presente artigo destaca-se a finalidade de propor melhorias no setor de marketing da empresa Tucuxi Rádio Táxi. Originou-se a partir de diagnóstico organizacional realizado na cooperativa onde podem ser estudadas todas as áreas funcionais da cooperativa e como consequência verifica-se deficiência no setor de marketing ocasionando assim pouca divulgação do serviço prestado pela empresa. A pesquisa teve como principal objetivo analisar como as mudanças tecnológicas podem tornar o portfólio de serviço da empresa mais competitivo e como objetivos específicos: identificar quais os obstáculos dentro das operações financeiras, setor de recursos humanos e comunicação; analisar as alternativas de que possibilitaram um aumento no retorno financeiro e desenvolvimento da comunicação e propor melhorias no processo que possibilitem maior crescimento do resultado financeiro operacional e na divulgação da empresa. A metodologia utilizada para realização da pesquisa se dividiu quanto aos fins sendo exploratórias e descritivas, e quanto ao meio aos meios, sendo uma pesquisa de campo, bibliográfica e documental. Foi adota uma ferramenta de qualidade 5W2H que auxiliou no planejamento das ações que consistem em contratação de um profissional de marketing com especialização em marketing digital, gerar tráfego pago, realizar campanhas de divulgação em rádios, criação de vídeos e planos de bônus para divulgação e para quem divulga o aplicativo. Com todas as mudanças sugeridas é esperado que o serviço fornecido pela empresa tivesse maior divulgação e consequentemente maior lucratividade.
ANALISIS PEMASARAN JERUK GERGA DI KECAMATAN RIMBO PENGADANG KABUPATEN LEBONG
Authors: Gabrienda Gracia , Murtiningrum Fery , Oktoyoki Hefri
Published: June 2021

Since citrus farming in Lebong Regency, Bengkulu Province, has begun to expand, this study is necessary to determine how the marketing channels and factors that affect the marketing margins of Gerga oranges in Rimbo Pengadang District, Lebong Regency. The marketing channel descriptive analysis was used as the analytical tool, and it describes the overall data collected. Multiple linear regression analysis with the formula Y = a + b1x1 + b2x2 + b3x3 + e is used to assess the variables that influence marketing margins. The marketing channel for gerga oranges in Rimbo Pengadang Village has 3 channel patterns, namely: farmers → retailers at village level → consumers, farmers → urban-level retailers → consumers, farmers → retailers at city level → consumers. It is well recognized that the three variables of sales volume, selling price, and marketing costs all influence marketing margins at the same time, resulting in a coefficient of multiple linear determinatio.
PENGGUNAAN FITUR HOG BERBASIS SUPERPIXEL UNTUK KLASIFIKASI JENIS JAMUR DENGAN METODE SVM
Authors: Yohannes Yohannes , Rachmat Nur , Saputra Calvin Oliver
Published: June 2021

Jamur memiliki banyak ragam dengan ciri yang mirip sehingga terdapat masalah dalam pengklasifikasian jenis dari jamur. Dataset citra jamur yang digunakan bernama Mushrooms classification – Common genus’s images yang berisi sembilan jenis jamur, yaitu Agaricus, Amanita, Boletus, Cortinarius, Entoloma, Hygrocybe, Lactarius, Russula, dan Suillus. Penggunaan fitur segmentasi dapat meningkatkan akurasi untuk masalah pengklasifikasian. Salah satu fitur segmentasi yang dapat digunakan adalah Superpixel (SLIC). Penelitian ini menggunakan dataset citra jamur yang di-resize. Metode SLIC digunakan untuk mensegmentasi citra jamur ke bentuk superpixel. Segmentasi citra ke superpixel ditujukan untuk mengkelompokkan piksel yang sejenis ke dalam region sehingga citra mudah diolah. HOG adalah fitur ekstraksi untuk mendeteksi objek. SVM sering digunakan sebagai metode klasifikasi karena mampu menghasilkan akurasi yang baik sehingga dapat mempelajari dan mengenali citra jamur. Penggunaan superpixel sebagai fitur segmentasi dengan jumlah region 1.200, kernel radial basis function (RBF), C bernilai sepuluh dan gamma scale memberikan hasil terbaik dengan akurasi sebesar 0,8329. Berdasarkan hasil pengujian yang didapat pada penelitian ini, superpixel dapat meningkatkan akurasi dari SVM pada dataset jamur dibandingkan dengan tanpa superpixel.
ОСОБЛИВОСТІ ЦІНОУТВОРЕННЯ НА ПРОДУКЦІЮ АПК
Authors: Кирилюк Ірина , Трохименко Андрій
Published: June 2021

У сучасних умовах ціни на продукцію АПК не є стабільними. Економічна ситуація в країні призводить до високої конкуренції на ринку сільськогосподарської продукції. Оскільки ціни на зерно для усіх підприємств майже однакові, фермерським господарствам слід уникати високих витрат на вирощування зернових та технічних культур задля конкурентоспроможності підприємства. Собівартість вирощування та зберігання зерна зростає, тому постає питання, чому так відбувається. У даній статті проаналізовано актуальні проблеми ціноутворення на продукцію сільського господарства в Україні. Виявлено основні причини диспаритету цін на сільськогосподарську продукцію. З’ясуємо проблеми і особливості з якими стикаються сільгоспвиробники під час формування ціни. Проаналізовано вплив державного регулювання на ціноутворення продукції АПК та запропоновано варіанти регулювання цін.
УПРАВЛІННЯ КАДРОВИМ ПОТЕНЦІАЛОМ АГРАРНОЇ СФЕРИ
Authors: Носань Наталія , Артеменко Сергій
Published: June 2021

Метою написання статті є дослідження особливостей управління кадровим потенціалом аграрної сфери. Для ефективного функціонування та розвитку підприємства необхідно постійно підвищувати рівень кваліфікації працівників – найважливіший елемент людських ресурсів. Працівник сучасного підприємства повинен мислити стратегічно, бути освіченим, культурним та швидко адаптуватися до мінливих умов навколишнього середовища. У статті обґрунтовано необхідність виділення особливостей управління кадровим потенціалом аграрної сфери. Виявлено основні проблеми кадрового потенціалу аграрної сфери, головними причинами виникнення яких є відсутність належної матеріальної винагороди за працю, втрата престижності професій працівників аграрної сфери. Виділена необхідна умова для розвитку ефективного механізму управління кадровим потенціалом аграрної сфери.
Testnevelő tanárok pályaválasztása és pályaelhagyása
Authors: Császár Attila
Published: June 2021

Magyarországon a nemzeti köznevelésről szóló 2011. évi CXC. törvény és a 2012. évi Nemzeti alaptanterv alapján bevezették a mindennapos testnevelést. Kutatásomban azt a kérdéskört vizsgálom, hogy a változások hatással voltak-e a leendő tanárok pályaválasztására; a gyakorló testnevelők tapasztaltak-e változást munkájuk megítélésében az oktatás különböző szereplőinek részéről, és mi lenne az oka annak, ha elhagynák a tanári pályát. A hazai szakirodalomban 2008-ban jelentek meg Bognár József és munkatársainak kutatási eredményei a Testnevelő tanárok presztízse: pályaválasztástól a pályaelhagyásig a nemek mentén címmel. Hazánkban korábban nem végeztek hasonlóan átfogó empirikus kutatást ebben a témában; ezért arra is választ keresek, hogy tíz évvel később jelentkezik-e jelentős különbség az eredményekben a kötelező mindennapos testnevelés bevezetésének hatására. Célom rávilágítani a testnevelők pályaválasztásának, presztízsének, lehetséges pályaelhagyásának jellemző jegyeire, illetve feltárni az esetleges különbségeket a nemek, az életkor és a köznevelésben eltöltött idő alapján. Az adatgyűjtés zárt végű kérdésekkel, Bognár és mtsai. 2008-as kutatásának átszerkesztett, feleletválasztásos kérdőíve alapján történt. A beérkezett válaszok feldolgozása leíró statisztikával, két- mintás t-próbával és varianciaanalízissel, az SPSS 16.0 for Windows statisztikai célszoftver segítségével történt.
Metodología de la enseñanza centrada en el aprendizaje
Authors: Villalpando Calderón Ma. Dolores
Published: June 2021

En el proceso educativo escolar, la función del profesor es la enseñanza, y la del estudiante es la realización de acciones que conduzcan al aprendizaje. Los enfoques actuales de la educación plantean procedimientos centrados en el aprendizaje de los estudiantes para conducirlos a la construcción del conocimiento y al logro de competencias sociales, profesionales y laborales, entre otras. En este artículo, se presentan algunos elementos que permiten identificar procedimientos de enseñanza para  actualizar  la  labor  docente  y  facilitar  el  aprendizaje  de  los  estudiantes dirigido a la formación integral de la persona, como se propone en el Modelo Educativo Institucional de la Universidad Autónoma de Aguascalientes (UAA).
En línea... seguimiento a las organizaciones
Authors: Medina Mayagoitia Norma Isabel
Published: June 2021

Bajo  la  consideración  de  que  la  apertura,  la  actualización  y  la  mejora  son  tres  condiciones  para  innovar,  surgió el  proyecto  “Seguimiento  Organizacional  en  Línea”  (SOL), con la idea de abrir posibilidades en la enseñanza y el aprendizaje, renovar métodos, mejorar la dinámica de trabajo y la participación estudiantil.
Enseñar la condición humana
Authors: González Alba Sara Celia
Published: June 2021

A doce años del inicio del siglo XXI, el mundo vive tiempos de cambios vertiginosos en todos los aspectos, ambientales, sociales, económicos, políticos, entre otros, y México no está exento de esta problemática. Es verdad que estos problemas no son nuevos, sino que nos vienen persiguiendo desde el siglo pasado y aún no se solucionan cuando ya están surgiendo otros nuevos, como la aparición de enfermedades desconocidas y la reaparición de conocidas; además, la cantidad de recursos necesarios para sustentar a la población humana es insuficiente, ya que la población humana supera la disponibilidad de dichos recursos.
Funcionalidad del constructivismo aplicado en un entorno ingenieril y estadístico
Authors: Márquez Elías Miguel Ángel
Published: June 2021

En este estudio se desarrolla la cuestión del diseño y aplicación de un proceso de enseñanza de carácter constructivista, referente a un curso dirigido a ingenieros industriales estadísticos en el nivel educativo terciario; asimismo, se revisan los resultados obtenidos. Los elementos involucrados en el diseño fueron: (1) antecedentes curriculares, (2) resolución de proyectos, (3) trabajo en grupos colaborativos, (4) evaluación por rúbricas, (5) autoevaluación, y (6) comunicación de resultados. Los resultados sugieren que esta forma de instrucción es altamente motivadora, desarrolla habilidades relevantes en los estudiantes de acuerdo a su perfil profesional, les permite madurar cognitivamente a la vez que los aprendizajes previos fructifican en otra dimensión: la aplicada.
Reseña del libro Once ideas clave: cómo aprender y enseñar competencias
Authors: Aldana Hernández María de los Ángeles
Published: June 2021

La obra de Antoni Zabala y Laia Arnau ofrece una propuesta con once  ideas  clave  que  integran  diversas  acepciones  sobre  el  término  competencia. Es un intento por clarificar la noción y la implicación de este componente en la educación. Es clara y evidente la postura de los autores  con  relación  a  la  perspectiva  de  formación  por  competencias  y el esfuerzo por justificar su implementación en enseñanza. Destaca, además, una clara intención de argumentar que el concepto “competencias” puede ser un medio notablemente eficaz para extender principios pedagógicos,  asumiendo  que  la  formación  en  competencias  es  renovadora  y  que  a  lo  largo  de  las  once  ideas  clave  se  ofrecen  razones  y  justificaciones que han de adoptarse en la educación.
Un reto para el profesor en la actualidad: las metodologías centradas en el aprendizaje
Authors: (DEFAA) Departamento de Formación y Actualización Académica , Gutiérrez Marfileño Victoria Eugenia
Published: June 2021

La Doctora en Educación Victoria Eugenia Gutiérrez Marfileño, en entrevista con el Departamento de Formación y Actualización Académica (DEFAA) nos da a conocer algunas de sus comprensiones sobre la enseñanza y nos comparte una experiencia realizada con un grupo de estudiantes implementando una metodología de enseñanza activa. Señala que se trata de métodos de enseñanza cuyos planteamientos coinciden con los realizados en el Modelo Educativo Institucional, sugiere que los profesores deben ir incorporando, de manera gradual, formas de enseñanza y evaluación del aprendizaje más acordes a las formulaciones de dicho Modelo cuyo propósito es la formación integral de los estudiantes de la UAA.
Ensamble Real de Jóvenes Universitarios. El arte musical en la formación integral en la UAA
Authors: Cerrillo López José de Jesús
Published: June 2021

¿Cómo se podría comenzar a relatar o introducir una historia de 15 años de actividad y producción artística de un exitoso proyecto educativo cultural de educación media superior en la Universidad Autónoma de Aguascalientes (UAA)? Las experiencias vividas y metas alcanzadas son muchas; asimismo, son incontables los estudiantes realizados y mucho el público testigo del nacimiento, desarrollo y crecimiento de esta primera agrupación de música orquestal en la universidad.
Perspectivas de la enseñanza de las matemáticas en la escuela contemporánea
Authors: Mazarío Triana Israel
Published: June 2021

Las razones de que se incluyan las matemáticas en los currículos escolares son múltiples y variadas. Por un lado, constituyen una eficaz herramienta de trabajo (tanto intelectual como práctica); y por otro, las matemáticas conforman un área de estudio que intenta comprender los modelos que impregnan el mundo que nos rodea.
Aprendizaje y retos en nuestra práctica docente. Reflexiones a partir del Diplomado en Innovación del Aprendizaje de la Universidad de Guanajuato
Authors: Caldera González Diana del Consuelo , Sánchez Ramos Ma. Eugenia , Barradas Bribiesca Ingrid
Published: June 2021

En este artículo se rescatan algunos aprendizajes al haber cursado el diplomado en Innovación del Aprendizaje de la Universidad de Guanajuato, con el objetivo de reflexionar en torno a tres grandes retos que como docentes tenemos. El primero, referido a la motivación en los estudiantes como motor para el aprendizaje; el segundo, a la creatividad e innovación necesarias en los docentes para implementar nuevas técnicas didácticas; y finalmente el tercero, respecto a la generación de comunidades de aprendizaje que involucren a estudiantes y profesores.
Reseña del libro: Trucos para el maestro. Cómo utilizar la tecnología en el aula
Authors: Bomy Pascal
Published: June 2021

En el presente texto se invita al lector a conocer la obra de las coordinadoras Sarah Corona Berkin y Citlalli González Ponce titulada "Trucos para el maestro. Cómo utilizar la tecnología en el aula", en donde varios autores se reúnen para responder a cuestionamientos acerca del entendimiento y participación en el mundo digital, así como el acercamiento de los profesores a las nuevas generaciones que parecen nacer con dispositivos digitales integrados.En la mayoría de los capítulos del libro, los autores trataron de organizarlos siguiendo tres ejes: cuál es el truco, cómo funciona y cómo se aplica, lo que en algunos casos puede parecer un planteamiento sumamente dirigido, pero que al final, el lector identifique la lógica en el mismo, y lo adapte de acuerdo a su necesidad como docente.
La enseñanza basada en la indagación en el área de las ciencias experimentales
Authors: Acosta Collazo Francisco Javier
Published: June 2021

En la actualidad, las prácticas pedagógicas presentan cierta complejidad al estar relacionadas con criterios de calidad externos, en donde los niveles de aprendizaje deberán ser evaluados y estar vinculados con el entorno. Además de lo anterior, en las ciencias experimentales como la Biología, se requiere de competencias disciplinares para la investigación en un entorno atractivo para el estudiante, en donde se promueva el desarrollo del pensamiento científico. El enfoque basado en la indagación fomenta los cuestionamientos en lugar de las respuestas, de manera que, mediante la aplicación de una estrategia educativa denominada “investigación individual”, se puede evaluar el proceso o ciclo de aprendizaje del método científico en los estudiantes.
Latet obscuris condita virtus clara tenebris: el arte del canon y las habilidades mentales (II)
Authors: Ammetto Fabrizio , Béjar Bartolo Alejandra
Published: June 2021

Este texto es la continuación –y conclusión– del artículo que apareció en el número 13 de la revista Docere, en donde se presentaron los cánones nos. 2, 10 y 11 extraídos de la colección impresa Artificii musicali, opus xiii (1689) de Giovanni Battista Vitali (1632-1692): de los cánones nos. 10 y 11 se proporcionaron las soluciones, mientras que se dejó al lector curioso y atento la tarea de descubrir el “enigma” del no. 2 (Vitali, 1689: 6), la Cantilena à quattro (“Cantilena a cuatro”) “en rueda”, o sea en círculo (Imagen 1), recordando que –según las palabras del mismo autor– se necesitaba “no de la crítica sino del estudio” (Vitali, 1689: 5).
La imprenta en la escuela: pedagogía del sujeto único y el trabajo cooperativo
Authors: Posada Ávila Héctor Homero
Published: June 2021

La nueva geografía humana en su carácter global y multidimensional instaura un mundo hiperconectado de acelerada innovación tecnológica. La educación superior enfrenta el desafío de operar en torno y dentro de emergencias culturales disímiles emanadas de tales dinámicas. La propuesta es resituar lo humano como eje vital, en contraparte del economicismo que afecta al medio ambiente, a la identidad cultural, al tejido social y al ámbito político. Es una proposición compleja y al mismo tiempo permisible, ya que desde el aula se gestan las transformaciones en el ser, conocer y hacer de los alumnos. En función de lo anterior, se intenta reinstalar, a través de la pedagogía de Célestin Freinet, aquella relación primigenia entre maestro-alumno, misma que, a manera de extrapolación, fue realizada en el contexto universitario como una experiencia de aprendizaje significativo que implicó tres momentos sustanciales: potenciar las facultades de la persona, reinventar el concepto incluyente y expansivo de la imprenta como dispositivo análogo al internet y, las nuevas tecnologías destinadas a dinamizar el trabajo individual y colectivo del alumno en la vida real.
Recursos digitales para la enseñanza y el aprendizaje de la historia
Authors: Terán Fuentes Aurora
Published: June 2021

La incorporación de los recursos digitales con fines educativos implica replantear la propia práctica docente, así como la didáctica a nivel general, tanto en los diferentes campos del conocimiento, como en los diversos niveles educativos; para el caso de la disciplina de la historia, se cuenta con una serie de alternativas digitales para fomentar aprendizajes, siempre y cuando sean parte de una planeación y cobren sentido dentro del curso que se imparta; ejemplos serían: fomentar la inteligencia espacial y visual a través de la producción de mapas o comprender la dimensión temporal por medio de la elaboración de líneas del tiempo, ambos recursos trabajados de forma gratuita y online.
Проблема когнітивних конфліктів і шляхів їхнього подолання
Authors: Гарькавець Сергій
Published: June 2021

У статті розглядається проблема когнітивних конфліктів індивідів у контексті сучасних умов їхнього існування. Зазначено, що когнітивні конфлікти базуються нанаявних в особистості ірраціональних ідеях, переконаннях та установках, щоінсталюються у формі вибіркового акценту на вирваному контексті з певної ситуації, генералізації проблем, переоцінці або недооцінці важливості фактів, чорно-білій картині мислення, вірі у теорії змови, що призводять до помилкових інтерпретацій подій та викривленню сприйняття реальних ситуацій.
З’ясовано, що індивіди, які заперечують існування коронавірусу SARS-CoV-2 або відмовляються від вакцинації, мають високий рівень тривожності, ригідності та екстравертованості, інсталюють образливість як ворожість, агресію, помсту та поводяться неефективно.
Запропоновані шляхи щодо подолання когнітивних конфліктів та їхнього вирішення на конструктивній основі.
Ключові слова:екстравертованість,когнітивний конфлікт, образа, ригідність, тривожність.
SOSYAL BİLGİLER ÖĞRETMEN ADAYLARININ YAPILANDIRMACILIK 5E MODELİ DERS PLANLARINDA YÖNTEM TERCİHLERİ VE MİKRO ÖĞRETİM UYGULAMASINA İLİŞKİN ÖZ DEĞERLENDİRMELERİ
Authors: TORUN Elif
Published: June 2021

Bu çalışmanın amacı Sosyal Bilgiler öğretmen adaylarının yapılandırmacılık 5E modeline dayalı olarak hazırladığı ders planlarında kullanmayı tercih ettikleri yöntem/teknikleri belirlemek ve mikro öğretim uygulaması sürecine ilişkin görüşlerini almaktır. Bu amaç doğrultusunda Sosyal Bilgiler öğretmen adaylarının ders planları analiz edilmiş ve mikro öğretim uygulaması sonrası öz değerlendirmeleri alınmıştır. Çalışma, 2018-2019 eğitim-öğretim yılı bahar yarıyılında yapılmıştır. Çalışma, 26’sı kadın 12’si erkek olmak üzere 38 üçüncü sınıf Sosyal Bilgiler öğretmen adayıyla yürütülmüştür. Çalışmada amaca yönelik örnekleme yöntemi tercih edilmiştir. Sosyal Bilgiler öğretmen adaylarının “Özel Öğretim Yöntemleri II” dersi kapsamında hazırladıkları yapılandırmacılık 5E modeline dayalı ders planları nitel araştırma yaklaşımlarından doküman analizi yöntemi kullanılarak incelenmiştir. Öz değerlendirme formu hazırlanırken, değerlendirmede dikkat edilecek hususlar alan uzmanı ile birlikte belirlenerek formun kapsam geçerliliği arttırılmış, sonrasında Sosyal Bilgiler öğretmen adaylarının görüşüne sunularak forma nihai şekli verilmiştir. Sosyal Bilgiler öğretmen adaylarının öz değerlendirmeleri ise içerik analizine tabi tutulmuştur. Çalışmadan elde edilen bulgulara göre Sosyal Bilgiler öğretmen adaylarının yapılandırmacılık 5E modeli ders planlarında en çok tercih ettikleri yöntem ve tekniklerin; oyun, iş birlikli öğrenme, metafor, drama, zihin haritası ile bilgisayar destekli yöntem ve teknikler olduğu belirlenmiştir. Sosyal Bilgiler öğretmen adaylarının ders planlarında öğrenci merkezli yöntem ve tekniklere daha sık yer verdiği tespit edilmiştir. Sosyal Bilgiler öğretmen adaylarının öz değerlendirme formları incelendiğinde mikro öğretim öncesi, heyecan, korku kodları ön plana çıkarken, mikro öğretim esnasında heyecan, rahat, mikro öğretim sonunda, rahat, mutlu kodlarının ön plana çıktığı belirlenmiştir. Sosyal Bilgiler öğretmen adaylarının kendilerinde beğendikleri yanların sınıf hakimiyeti, özgüven; beğenmedikleri veya değiştirmek istedikleri yanların ise dil anlatım, etkinlikler olduğu belirlenmiştir. Bulgulardan yola çıkarak Sosyal Bilgiler öğretmen adaylarının zengin bir yöntem ve teknik bilgisine sahip olduğu ve kendilerine dair gerçekçi değerlendirmelerde bulundukları sonucuna ulaşılmıştır.
Clinical Considerations in Otorhinolaryngology Practice in COVID-19 Pandemic Era
Authors: Son Soo Ah , Hwang Se Hwan
Published: June 2021

The coronavirus disease 2019 (COVID-19) epidemic originated in Wuhan, China and spread rapidly worldwide, leading the World Health Organization to declare an official global COVID- 19 pandemic in March 2020. The upper aero-digestive tract is known to be the highest viral load reside. The infection spreads via droplets or direct contact with contaminated surfaces via aeorsol. The otolaryngologists deal with diseases of the upper-aerodigestive tract and routinely are engaged in respiratory droplet and aerosol-generating procedures (AGP). In particular, because airborne transmission occurs during examination and AGP, otolaryngologists are considered to be at a high risk of contracting COVID-19 during this pandemic. Therefore otolaryngologists need to do precautions to protect staff and patients and minimize transmission of the disease. We also need to wear adequate personal protective equipment according to the examination and procedure. This article discusses the disease transmission and clinical characteristics of COVID-19 as well as precaution guidelines in outpatient clinics of otorhinolaryngology.
Microorganisms in the biological control of root-knot nematode: A metanalytical study
Authors: Benedetti Tatiana , Huzar-Novakowiski Jaqueline , Sordi Elisangela , Carvalho Ivan Ricardo , Bortoluzzi Edson Campanhola
Published: June 2021

Nematodes can cause annual losses in the order of 100 billion dollars in crops worldwide. Its control using chemical nematicides proves to be quite aggressive to the environment. For this reason, the management of microorganisms has been promising. However, it is essential to know the control potential of each organism. Thus, the objective of this study was to verify the efficiency of different microorganisms in the biological control of Meloidogyne sp. A systematic review of the literature was carried out from 2000 to 2020 with the keywords “Meloidogyne and biology control", resulting in 659 articles, of which 51 were pre-selected and, after the more detailed evaluation, was selected ten published articles. These ten articles generated a total of 83 studies for meta-analyses. Each study included a treatment group using some microorganisms (bacteria, fungus, actinomycetes) for nematode biocontrol, a control group without using biocontrol agents. From this meta-analysis, we can observe that the use of microorganisms decreased the number of galls (42.05%), the number of eggs (57.77%), the gall index (28.58%) and the eggs mass (53.48%). The use of microorganisms was also positive in increasing root mass (832.89%). We can conclude that the use of microorganisms proved to be efficient in controlling nematodes M. javanica and M. incognita. The fungi Pleurotus ostreatus and Phanerochaete chrysosporium have more significant potential for biocontrol for these species.
Ações de enfermagem junto aos portadores de diabetes mellitus residentes da zona rural
Authors: Silva Regiane Maria Peregrina Roberto da , Silva Vanessa Rangel Nunes e , Paz Francisco Adalberto do Nascimento
Published: June 2021

A assistência de enfermagem é crucial no que se refere ao cuidado do paciente acometido pelo diabetes mellitus, bem como o desenvolvimento de ações, principalmente àqueles que residem em ambiente rural por apresentarem um estilo de vida particular, além disso, enfrentam dificuldades no acesso ao serviço de saúde ou acessibilidade reduzida devido a não residir próximo a esses institutos. O objetivo deste estudo foi investigar as publicações que tratam das ações de enfermagem realizadas junto aos portadores de diabetes mellitus residentes da zona rural, com destaque aos aspectos relevantes apontados por estes profissionais enfermeiros que atuam na assistência dessas pessoas, conforme as publicações científicas. Utilizou-se a revisão integrativa, em que 10 artigos científicos disponibilizados na íntegra, nos últimos 5 anos, selecionados na Biblioteca Virtual de Saúde, compuseram a amostra analisada. Os resultados demonstraram a relevância do desenvolvimento das ações do profissional enfermeiro frente aos pacientes acometidos pelo diabetes mellitus e os resultados positivos destas, mostram que a aplicabilidade e aperfeiçoamento dessas ações que podem ser desenvolvidas pelo profissional enfermeiro são de total relevância, tanto para a prevenção, como para a lida com a doença depois de diagnosticada, principalmente no cenário rural onde ficou evidenciada a necessidade de um olhar mais especial para estes.
Common ethical dilemmas of family caregivers of palliative patients in Indonesia
Authors: Kristanti Martina Sinta , Kusmaryanto Kusmaryanto , Effendy Christantie
Published: June 2021

Family caregivers, especially in Asian countries, have a profound role in caring for a sick family member. However, there are wide variations between the Asian and western world in terms of culture and facilities. Therefore, the problems and needs of family caregivers between those two regions may also be distinct, and it is important to explore and elaborate based on our empirical evidence. In Indonesia, motives and values in caregiving and religion become the wheel-power of the family caregivers in providing care. This affects action and consequences for caregivers. This paper attempts to elaborate on common ethical dilemmas that usually face by family caregivers in Indonesia. Unfortunately, family caregivers typically are not prepared to make those challenging decisions. Therefore, we recommend not only that family caregivers need to be involved in the caring process, but also their issues and ethical dilemmas should be assessed and addressed by health care professionals, especially nurses, who have the most frequent contact with patient and family caregiver.
HASIL BELAJAR MATEMATIKA SISWA MELALUI PEMBELAJARAN DARING
Authors: Nur Fitriani
Published: June 2021

The paradigm of online learning is an alternative at every level of education today. This study aims to describe students' math learning outcomes through online learning. The study involving all 1st graders of Madrasah Ibtidaiyah Madani Alauddin as many as 47 people used observation sheet instruments and documentation of learning results and analyzed using descriptive statistics. The results of this study showed that the average math learning outcomes of students are in the excellent category through online learning. Another finding from this study is that there are still 11% of students who need guidance on mathematics learning, so that further research can explore factors that hinder the understanding of student math learning today.
What happens when mental health concerns bring young people into contact with the law? The promise of trauma informed practice
Authors: McVie Susan
Published: June 2021

Tens of thousands of children and young people have adversarial contact with law enforcement agencies in the UK every year. Despite a large reduction in the prevalence of youth offending in recent years, available evidence shows that those who do come into contact with the police and other justice agencies are increasingly vulnerable and have complex needs. A very high proportion of them have problems with their mental health. Justice organisations are not necessarily equipped to cope with mental health problems and do not always have good assessment tools or suitably trained staff. However, a trauma informed approach to dealing with young people in conflict with the law offers significant promise in terms of identifying young people in mental distress and developing positive strategies for ensuring they are dealt with appropriately and effectively.
Combined Effects of Exercise and Denosumab Treatment on Local Failure in Post-menopausal Osteoporosis–Insights from Bone Remodelling Simulations Accounting for Mineralisation and Damage
Authors: Martínez-Reina Javier , Calvo-Gallego José L. , Pivonka Peter
Published: June 2021

Denosumab has been shown to increase bone mineral density (BMD) and reduce the fracture risk in patients with post-menopausal osteoporosis (PMO). Increase in BMD is linked with an increase in bone matrix mineralisation due to suppression of bone remodelling. However, denosumab anti-resorptive action also leads to an increase in fatigue microdamage, which may ultimately lead to an increased fracture risk. A novel mechanobiological model of bone remodelling was developed to investigate how these counter-acting mechanisms are affected both by exercise and long-term denosumab treatment. This model incorporates Frost's mechanostat feedback, a bone mineralisation algorithm and an evolution law for microdamage accumulation. Mechanical disuse and microdamage were assumed to stimulate RANKL production, which modulates activation frequency of basic multicellular units in bone remodelling. This mechanical feedback mechanism controls removal of excess bone mass and microdamage. Furthermore, a novel measure of bone local failure due to instantaneous overloading was developed. Numerical simulations indicate that trabecular bone volume fraction and bone matrix damage are determined by the respective bone turnover and homeostatic loading conditions. PMO patients treated with the currently WHO-approved dose of denosumab (60 mg administrated every 6 months) exhibit increased BMD, increased bone ash fraction and damage. In untreated patients, BMD will significantly decrease, as will ash fraction; while damage will increase. The model predicted that, depending on the time elapsed between the onset of PMO and the beginning of treatment, BMD slowly converges to the same steady-state value, while damage is low in patients treated soon after the onset of the disease and high in patients having PMO for a longer period. The simulations show that late treatment PMO patients have a significantly higher risk of local failure compared to patients that are treated soon after the onset of the disease. Furthermore, overloading resulted in an increase of BMD, but also in a faster increase of damage, which may consequently promote the risk of fracture, specially in late treatment scenarios. In case of mechanical disuse, the model predicted reduced BMD gains due to denosumab, while no significant change in damage occurred, thus leading to an increased risk of local failure compared to habitual loading.
Engineering of Chinese Hamster Ovary Cells With NDPK-A to Enhance DNA Nuclear Delivery Combined With EBNA1 Plasmid Maintenance Gives Improved Exogenous Transient Reporter, mAb and SARS-CoV-2 Spike Protein Expression
Authors: Budge James D. , Young Robert J. , Smales Christopher Mark
Published: June 2021

Transient gene expression (TGE) in mammalian cells is a method of rapidly generating recombinant protein material for initial characterisation studies that does not require time-consuming processes associated with stable cell line construction. High TGE yields are heavily dependent on efficient delivery of plasmid DNA across both the plasma and nuclear membranes. Here, we harness the protein nucleoside diphosphate kinase (NDPK-A) that contains a nuclear localisation signal (NLS) to enhance DNA delivery into the nucleus of CHO cells. We show that co-expression of NDPK-A during transient expression results in improved transfection efficiency in CHO cells, presumably due to enhanced transportation of plasmid DNA into the nucleus via the nuclear pore complex. Furthermore, introduction of the Epstein Barr Nuclear Antigen-1 (EBNA-1), a protein that is capable of inducing extrachromosomal maintenance, when coupled with complementary oriP elements on a transient plasmid, was utilised to reduce the effect of plasmid dilution. Whilst there was attenuated growth upon introduction of the EBNA-1 system into CHO cells, when both NDPK-A nuclear import and EBNA-1 mediated technologies were employed together this resulted in enhanced transient recombinant protein yields superior to those generated using either approach independently, including when expressing the complex SARS-CoV-2 spike (S) glycoprotein.
Long Non-coding RNA MSTRG.24008.1 Regulates the Regeneration of the Sciatic Nerve via the miR-331-3p–NLRP3/MAL Axis
Authors: Yin Gang , Peng Ying , Lin Yaofa , Wang Peilin , Li Zhuoxuan , Wang Renyuan , Lin Haodong
Published: June 2021

Peripheral nerve injury (PNI) is a common clinical problem, which can cause severe disability and dramatically affect a patient’s quality of life. Neural regeneration after PNI is a complex biological process that involves a variety of signaling pathways and genes. Emerging studies demonstrated that long non-coding RNAs (lncRNAs) were abnormally expressed after PNI and played pivotal roles in peripheral nerve regeneration. Based on the rat sciatic nerve injury model, we found that the expression levels of several lncRNAs were increased significantly in the sciatic nerve after injury. Software prediction prompted us to focus on one up-regulated lncRNA, MSTRG.24008.1. Dual-luciferase reporter assay, RNA pull-down assay and RNA interference approach verified that MSTRG.24008.1 regulated neuroregeneration via the miR-331-3p/nucleotide-binding oligomerization domain-like pyrin domain containing 3 (NLRP3)/myelin and lymphocyte protein (MAL) axis in vitro. Subsequently, we performed gastrocnemius muscle gravity and sciatic functional index experiments to evaluate the recovery of injured sciatic nerves after MSTRG.24008.1 siRNA interference in vivo. In conclusion, knockdown of MSTRG.24008.1 promotes the regeneration of the sciatic nerve via the miR-331-3p/NLRP3/MAL axis, which may provide a new strategy to evaluate and repair injured peripheral nerves clinically.
Analyzing Metabolic States of Adipogenic and Osteogenic Differentiation in Human Mesenchymal Stem Cells via Genome Scale Metabolic Model Reconstruction
Authors: Sigmarsdottir Thora Bjorg , McGarrity Sarah , Yurkovich James T. , Rolfsson Óttar , Sigurjónsson Ólafur Eysteinn
Published: June 2021

Since their initial discovery in 1976, mesenchymal stem cells (MSCs) have been gathering interest as a possible tool to further the development and enhancement of various therapeutics within regenerative medicine. However, our current understanding of both metabolic function and existing differences within the varying cell lineages (e.g., cells in either osteogenesis or adipogenesis) is severely lacking making it more difficult to fully realize the therapeutic potential of MSCs. Here, we reconstruct the MSC metabolic network to understand the activity of various metabolic pathways and compare their usage under different conditions and use these models to perform experimental design. We present three new genome-scale metabolic models (GEMs) each representing a different MSC lineage (proliferation, osteogenesis, and adipogenesis) that are biologically feasible and have distinctive cell lineage characteristics that can be used to explore metabolic function and increase our understanding of these phenotypes. We present the most distinctive differences between these lineages when it comes to enriched metabolic subsystems and propose a possible osteogenic enhancer. Taken together, we hope these mechanistic models will aid in the understanding and therapeutic potential of MSCs.
Interplay of Forces and the Immune Response for Functional Tendon Regeneration
Authors: Yang Yuwei , Wu Yicong , Zhou Ke , Wu Dongmei , Yao Xudong , Heng Boon Chin , Zhou Jing , Liu Hua , Ouyang Hongwei
Published: June 2021

Tendon injury commonly occurs during sports activity, which may cause interruption or rapid decline in athletic career. Tensile strength, as one aspect of tendon biomechanical properties, is the main parameter of tendon function. Tendon injury will induce an immune response and cause the loss of tensile strength. Regulation of mechanical forces during tendon healing also changes immune response to improve regeneration. Here, the effects of internal/external forces and immune response on tendon regeneration are reviewed. The interaction between immune response and internal/external forces during tendon regeneration is critically examined and compared, in relation to other tissues. In conclusion, it is essential to maintain a fine balance between internal/external forces and immune response, to optimize tendon functional regeneration.
α-Ketoglutarate Upregulates Collecting Duct (Pro)renin Receptor Expression, Tubular Angiotensin II Formation, and Na+ Reabsorption During High Glucose Conditions
Authors: Guerrero Aarón , Visniauskas Bruna , Cárdenas Pilar , Figueroa Stefanny M. , Vivanco Jorge , Salinas-Parra Nicolas , Araos Patricio , Nguyen Quynh My , Kassan Modar , Amador Cristián A. , Prieto Minolfa C. , Gonzalez Alexis A.
Published: June 2021

Diabetes mellitus (DM) causes high glucose (HG) levels in the plasma and urine. The (pro)renin receptor (PRR) is a key regulator of renal Na+ handling. PRR is expressed in intercalated (IC) cells of the collecting duct (CD) and binds renin to promote angiotensin (Ang) II formation, thereby contributing to Na+ reabsorption. In DM, the Kreb's cycle is in a state of suppression in most tissues. However, in the CD, expression of glucose transporters is augmented, boosting the Kreb's cycle and consequently causing α-ketoglutarate (αKG) accumulation. The αKG receptor 1 (OXGR1) is a Gq-coupled receptor expressed on the apical membrane of IC cells of the CD. We hypothesize that HG causes αKG secretion and activation of OXGR1, which increases PRR expression in CD cells. This effect then promotes intratubular AngII formation and Na+ reabsorption. To test this hypothesis, streptozotocin (STZ)-induced diabetic mice were treated with or without montelukast (ML), an OXGR1 antagonist, for 6 days. STZ mice had higher urinary αKG and PRR expression along with augmented urinary AngII levels and Na+ retention. Treatment with ML prevented all these effects. Similarly, primary cultured inner medullary CD cells treated with HG showed increased PRR expression, while OXGR1 antagonist prevented this effect. αKG increases PRR expression, while treatments with ML, PKC inhibition, or intracellular Ca2+ depletion impair this effect. In silico analysis suggested that αKG binds to mouse OXGR1. These results indicate that HG conditions promote increased levels of intratubular αKG and OXGR1-dependent PRR upregulation, which impact AngII formation and Na+ reabsorption.
Metformin Improves Autonomic Nervous System Imbalance and Metabolic Dysfunction in Monosodium L-Glutamate-Treated Rats
Authors: Franco Claudinéia Conationi da Silva , Previate Carina , Trombini Amanda Bianchi , Miranda Rosiane Aparecida , Barella Luiz Felipe , Saavedra Lucas Paulo Jacinto , de Oliveira Júlio Cezar , Prates Kelly Valério , Tófolo Laize Peron , Ribeiro Tatiane Aparecida , Pavanello Audrei , Malta Ananda , Martins Isabela Peixoto , Moreira Veridiana Motta , Matiusso Camila Cristina Ianoni , Francisco Flávio Andrade , Alves Vander Silva , de Moraes Ana Maria Praxedes , de Sant Anna Juliane Rocha , de Castro Prado Marialba Avezum Alves , Gomes Rodrigo Mello , Vieira Elaine , de Freitas Mathias Paulo Cezar
Published: June 2021

Metformin is an antidiabetic drug used for the treatment of diabetes and metabolic diseases. Imbalance in the autonomic nervous system (ANS) is associated with metabolic diseases. This study aimed to test whether metformin could improve ANS function in obese rats. Obesity was induced by neonatal treatment with monosodium L-glutamate (MSG). During 21–100 days of age, MSG-rats were treated with metformin 250 mg/kg body weight/day or saline solution. Rats were euthanized to evaluate biometric and biochemical parameters. ANS electrical activity was recorded and analyzed. Metformin normalized the hypervagal response in MSG-rats. Glucose-stimulated insulin secretion in isolated pancreatic islets increased in MSG-rats, while the cholinergic response decreased. Metformin treatment normalized the cholinergic response, which involved mostly the M3 muscarinic acetylcholine receptor (M3 mAChR) in pancreatic beta-cells. Protein expression of M3 mAChRs increased in MSG-obesity rats, while metformin treatment decreased the protein expression by 25%. In conclusion, chronic metformin treatment was effective in normalizing ANS activity and alleviating obesity in MSG-rats.
The Complicated Effects of Extracellular Vesicles and Their Cargos on Embryo Implantation
Authors: Jiang Nan-Xing , Li Xue-Lian
Published: June 2021

As a rate-limiting step in pregnancy, embryo implantation is highly dependent on intercellular communication. Extracellular vesicles (EVs) are newly identified to be important in the course of intercellular communication. EVs have been isolated from a wide variety of biofluids and tissues, including plasma, liver, uterine, semen, embryo, etc. The present and future use of EVs not only as biomarkers, but also as targeting drug delivery system, is promisingly pave the way for advanced comprehension of implantation failure in reproductive diseases. However, as the precise mechanisms of EVs in embryo implantation has not been elucidated yet. Herein, we summarize the current knowledge on the diverse effects of EVs from various sources and their cargos such as microRNA, long non-coding RNA, protein, etc. on embryo implantation, and the potential mechanisms of EVs in reproductive diseases such as recurrent implantation failure, polycystic ovary syndrome and endometriosis. It is essential to note that many of the biologically plausible functions of EVs in embryo implantation discussed in present literatures still need further researchin vivo.