bluuebunny/crossref_metadata_2025 huggingface dataset:
Human Papillomaviruses in Adolescents: Knowledge, Attitudes, and Practices of Pharmacists Regarding Virus and Vaccination in France
Authors: Dufour Lucas , Carrouel Florence , Dussart Claude
Published: March 2023

Human papillomaviruses (HPVs) are responsible for one of the most common sexually transmitted diseases in the world, and their oncogenic role has been well demonstrated in genital, anal, and oropharyngeal areas. However, a certain distrust and a lack of knowledge about this vaccine are perceptible among French adolescents and their parents. Thus, health professionals and, more particularly, pharmacists appear to be key persons to promote HPV vaccination and restore confidence in the target population. The present study aims to assess the knowledge, attitudes, and practices regarding HPV vaccination among pharmacists, particularly in boys, following the 2019 recommendation to vaccinate them. The present study was designed as a cross-sectional, quantitative, and descriptive survey that was conducted from March to September 2021 among pharmacists in France. 215 complete questionnaires were collected. Gaps in knowledge were found, only 21.4% and 8.4% obtained a high level of knowledge related to, respectively, HPV and vaccination. Pharmacists were confident in the HPV vaccine (94.4%), found it safe and useful, and felt that the promotion of the vaccine was part of their role (94.0%). However, only a few have already advised it, which they justify due to a lack of opportunity and forgetfulness. Faced with this, training, computerized reminders, or supportive materials could be implemented to improve the advice and thus the vaccination coverage. Finally, 64.2% were in favor of a pharmacy-based vaccination program. In conclusion, pharmacists are interested in this vaccination and the role of promoter. However, they need the means to facilitate this mission: training, computer alerts, supportive materials such as flyers, and the implementation of vaccination in pharmacies.
Above-Standard Survival of Hepatocellular Carcinoma as the Final Outcome of Comprehensive Hepatology Care Programs in a Remote HCV-Endemic Area
Authors: Cho Wei-Ru , Huang Hui-Ling , Hsu Nien-Tzu , Huang Tung-Jung , Chang Te-Sheng
Published: March 2023

Early detection and prompt linkage to care are critical for hepatocellular carcinoma (HCC) care. Chang Gung Memorial Hospital (CGMH) Yunlin branch, a local hospital in a rural area, undertakes health checkup programs in addition to its routine clinical service. Patients with HCC are referred to CGMH Chiayi branch, a tertiary referral hospital, for treatment. This study enrolled 77 consecutive patients with newly diagnosed HCCs between 2017 and 2022, with a mean age of 65.7 ± 11.1 years. The screening group included HCC patients detected through health checkups, and those detected by routine clinical service served as the control group. Compared to the 24 patients in the control group, the 53 patients in the screening group had more cases with early stage cancer (Barcelona Clinic Liver Cancer or BCLC stage 0 + A 86.8% vs. 62.5%, p = 0.028), better liver reserve (albumin–bilirubin or ALBI grade I 77.3% vs. 50%, p = 0.031) and more prolonged survival (p = 0.036). The median survival rates of the 77 patients were >5 years, 3.3 years, and 0.5 years in the BCLC stages 0 + A, B, and C, respectively, which were above the expectations of the BCLC guideline 2022 for stages 0, A, and B. This study provides a model of HCC screening and referral to high-quality care in remote viral-hepatitis-endemic areas.
One Health Surveillance Highlights Circulation of Viruses with Zoonotic Potential in Bats, Pigs, and Humans in Viet Nam
Authors: Latinne Alice , Nga Nguyen Thi Thanh , Long Nguyen Van , Ngoc Pham Thi Bich , Thuy Hoang Bich ,   PREDICT Consortium, Long Nguyen Van , Long Pham Thanh , Phuong Nguyen Thanh , Quang Le Tin Vinh , Tung Nguyen , Nam Vu Sinh , Duoc Vu Trong , Thinh Nguyen Duc , Schoepp Randal , Ricks Keersten , Inui Ken , Padungtod Pawin , Johnson Christine K. , Mazet Jonna A. K. , Walzer Chris , Olson Sarah H. , Fine Amanda E.
Published: March 2023

A One Health cross-sectoral surveillance approach was implemented to screen biological samples from bats, pigs, and humans at high-risk interfaces for zoonotic viral spillover for five viral families with zoonotic potential in Viet Nam. Over 1600 animal and human samples from bat guano harvesting sites, natural bat roosts, and pig farming operations were tested for coronaviruses (CoVs), paramyxoviruses, influenza viruses, filoviruses and flaviviruses using consensus PCR assays. Human samples were also tested using immunoassays to detect antibodies against eight virus groups. Significant viral diversity, including CoVs closely related to ancestors of pig pathogens, was detected in bats roosting at the human–animal interfaces, illustrating the high risk for CoV spillover from bats to pigs in Viet Nam, where pig density is very high. Season and reproductive period were significantly associated with the detection of bat CoVs, with site-specific effects. Phylogeographic analysis indicated localized viral transmission among pig farms. Our limited human sampling did not detect any known zoonotic bat viruses in human communities living close to the bat cave and harvesting bat guano, but our serological assays showed possible previous exposure to Marburg virus-like (Filoviridae), Crimean–Congo hemorrhagic fever virus-like (Bunyaviridae) viruses and flaviviruses. Targeted and coordinated One Health surveillance helped uncover this viral pathogen emergence hotspot.
Dutch Healthcare Professionals’ Opinion on the Allocation of Responsibilities concerning Prescribing and Administering Medically Indicated Vaccines to Immunocompromised Patients
Authors: te Linde Elsemieke , Doornekamp Laura , Daenen Katrijn C. P. , van Gorp Eric C. M. , Bruns Anke H. W.
Published: March 2023

Background: Specific vaccines are indicated for immunocompromised patients (ICPs) due to their vulnerability to infections. Recommendation of these vaccines by healthcare professionals (HCPs) is a crucial facilitator for vaccine uptake. Unfortunately, the responsibilities to recommend and administer these vaccines are not clearly allocated among HCPs involved in the care of adult ICPs. We aimed to evaluate HCPs’ opinions on directorship and their role in facilitating the uptake of medically indicated vaccines as a basis to improve vaccination practices. Methods: A cross-sectional survey was performed among in-hospital medical specialists (MSs), general practitioners (GPs), and public health specialists (PHSs) in the Netherlands to assess their opinion on directorship and the implementation of vaccination care. Additionally, perceived barriers, facilitators, and possible solutions to improve vaccine uptake were investigated. Results: In total, 306 HCPs completed the survey. HCPs almost unanimously (98%) reported that according to them, the primary treating physician is responsible for recommending medically indicated vaccines. Administering these vaccines was seen as a more shared responsibility. The most important barriers experienced by HCPs in recommending and administering were reimbursement problems, a lack of a national vaccination registration system, insufficient collaboration among HCPs, and logistical problems. MSs, GPs and PHSs all mentioned the same three solutions as important strategies to improve vaccination practices, i.e., reimbursement of vaccines, reliable and easily accessible registration of received vaccines, and arrangements for collaboration among the different HCPs that are involved in care. Conclusion: The improvement in vaccination practices in ICPs should focus on better collaboration among MSs, GPs, and PHSs, who should know each other’s expertise; clear agreement on responsibility; reimbursement for vaccines; and the availability of clear registration of vaccination history.
Retrospective Analysis of Vaccinated and Unvaccinated COVID-19 Patients Treated with Monoclonal Antibodies (mAb) and Their Emergent Needs (RAVEN)
Authors: Simeunovic Gordana , Polega James , Toor Subhan , Andersen Nicholas J.
Published: March 2023

Strategies to combat COVID-19 include vaccines and Monoclonal Antibody Therapy. While vaccines aim to prevent development of symptoms, Monoclonal Antibody Therapy aims to prevent the progression of mild to severe disease. An increasing number of COVID-19 infections in vaccinated patients raised the question of whether vaccinated and unvaccinated COVID-19 positive patients respond differently to Monoclonal Antibody Therapy. The answer can help prioritize patients if resources are scarce. We performed a retrospective study to evaluate and compare the outcomes and risks for disease progression between vaccinated and unvaccinated COVID-19 patients treated with Monoclonal Antibody Therapy by measuring the number of Emergency Department visits and hospitalizations within 14 days as well as the progression to severe disease, defined through the Intensive Care Unit admissions within 14 days, and death within 28 days from the Monoclonal Antibody infusion. From 3898 included patients, 2009 (51.5%) were unvaccinated at the time of Monoclonal Antibody infusion. Unvaccinated patients had more Emergency Department visits (217 vs. 79, p < 0.0001), hospitalizations (116 vs. 38, p < 0.0001), and progression to severe disease (25 vs. 19, p = 0.016) following treatment with Monoclonal Antibody Therapy. After adjustment for demographics and comorbidities, unvaccinated patients were 2.45 times more likely to seek help in the Emergency Department and 2.70 times more likely to be hospitalized. Our data suggest the added benefit between the COVID-19 vaccine and Monoclonal Antibody Therapy.
Longitudinal Profiles of Anti-Platelet Factor 4 Antibodies in Thai People Who Received ChAdOx1 nCoV-19 Vaccination
Authors: Hantrakun Nonthakorn , Sinsakolwat Peampost , Tantiworawit Adisak , Rattarittamrong Ekarat , Rattanathammethee Thanawat , Hantrakool Sasinee , Piriyakhuntorn Pokpong , Punnachet Teerachat , Niprapan Piangrawee , Wongtagan Ornkamon , Chaiwarith Romanee , Norasetthada Lalita , Chai-Adisaksopha Chatree
Published: March 2023

Anti-platelet factor 4 (anti-PF4) antibodies were identified as pathogenic antibodies for vaccine-induced immune thrombocytopenia and thrombosis (VITT) in subjects receiving ChAdOx1 nCoV-19 vaccinations. We performed a prospective cohort study to determine the prevalence of anti-PF4 and the effect of the ChAdOx1 nCoV-19 vaccine on anti-PF4 in healthy Thai subjects. Anti-PF4 antibodies were measured before and four weeks after receiving the first vaccination. Participants with detectable antibodies were scheduled for repeat anti-PF4 analysis at 12 weeks after the second vaccination. Of 396 participants, ten participants (2.53%; 95% confidence interval [CI], 1.22–4.59) were positive for anti-PF4 before receiving vaccinations. Twelve people (3.03%; 95% CI, 1.58–5.23) had detectable anti-PF4 after the first vaccination. There was no difference in the optical density (OD) values of anti-PF4 antibodies when comparisons were made between pre-vaccination and four weeks after the first vaccination (p = 0.0779). There was also no significant difference in OD values in participants with detectable antibodies. No subjects experienced thrombotic complications. Pain at the injection site was associated with an increased risk of being anti-PF4 positive at an odds ratio of 3.44 (95% CI, 1.06–11.18). To conclude, the prevalence of anti-PF4 was low in Thais and did not significantly change over time.
Evaluation of the Approach towards Vaccination against COVID-19 among the Polish Population—In Relation to Sociodemographic Factors and Physical and Mental Health
Authors: Gołębiowska Justyna , Zimny-Zając Anna , Dróżdż Mateusz , Makuch Sebastian , Dudek Krzysztof , Mazur Grzegorz , Agrawal Siddarth
Published: March 2023

Due to the rapid development of COVID-19 vaccines, the world has faced a huge challenge with their general acceptance, including Poland. For this reason, we attempted to determine the sociodemographic factors influencing the decision of positive or negative attitudes toward COVID-19 vaccination. The analysis included 200,000 Polish participants—80,831 women (40.4%) and 119,169 men (59.6%). The results revealed that the most common reasons for vaccine refusal and hesitancy were the fear of post-vaccination complications and their safety (11,913/31,338, 38.0%; 9966/31,338, 31.8%). Negative attitudes were observed more often among male respondents with primary or secondary education (OR = 2.01, CI95% [1.86–2.17] and OR = 1.52, CI95% [1.41–1.63], respectively). On the other hand, older age ≥ 65 (OR = 3.69; 95%CI [3.44–3.96]), higher education level (OR = 2.14; 95%CI [2.07–2.22]), living in big cities with a range of 200,000–499,999 inhabitants and more than 500,000 inhabitants (OR = 1.57, CI95% [1.50–1.64] and OR = 1.90, CI95% [1.83–1.98], respectively), good physical conditions (OR = 2.05; CI95% [1.82–2.31]), and at last normal mental health conditions (OR = 1.67, CI95% [1.51–1.85]) were significantly associated with COVID-19 vaccine acceptance. Our study indicates which population group should be further supplied with data and information by health education, the government, and healthcare professionals to alleviate the negative attitude toward COVID-19 vaccines.
Assessing Urban Flooding Extent of the Baunia Khal Watershed in Dhaka, Bangladesh
Authors: Subah Zarin , Bala Sujit Kumar , Ryu Jae Hyeon
Published: March 2023

Due to the gradual encroachment of natural drainage channels (also known as khals) and the poor management of drainage infrastructures, any rainfall of higher intensity for a few hours causes urban flooding in Dhaka, Bangladesh, hindering the daily lives of city dwellers, especially in slum areas. The Intensity–Duration–Frequency (IDF) curves with return intervals of 2, 5, 10, 25, 50, and 100 years were estimated for a 3 h duration of rainfall using the Gumbel statistical method to assess urban flooding extent around the Baganbari slum within the Baunia Khal watershed. The spatial land use changes of the Baunia Khal were also delineated through the analysis of the areal changes of the khal from 2004 to 2020. The area of the khal was found to be 7.00 km2, 2.17 km2 and 0.41 km2 for the years 2004, 2010, and 2020, respectively. It appears that a gradual massive areal decrease of the khal (impervious land segment) was in progress during this period for high encroachments driven by various governmental agencies and other private entities’ urban developmental projects. The runoff coefficient was computed as 0.76 based on the existing land use pattern, slope, and soil type of the study area. The average runoff generated from the catchment was estimated using the rational method and was 103.41 m3/hr. The drainage length was calculated as 9.1 km using the Kirpich method, whereas the present drainage length was reported as only 6.95 km. The multiple rainfall intensities with return periods of 2, 5, 10, 25, 50, and 100 years were also applied to replicate a heightened extent of urban flooding in the Baunia Khal watershed. The study suggests that the depth, length and width of the Baunia Khal need to increase to hold the generated runoff to manage urban flooding around the Baunia Khal watershed.
Marine Hazard Assessment of Soluble and Nanostructured Forms of the Booster Biocide DCOIT in Tropical Waters
Authors: Perina Fernando , Ottoni Cristiane , Santos Juliana , Santos Vithória , Silva Mariana , Campos Bruno , Fontes Mayana , Santana Debora , Maia Frederico , Abessa Denis , Martins Roberto
Published: March 2023

The encapsulation of antifouling compounds, such as DCOIT (4,5-Dichloro-2-octylisothiazol-3(2H)-one), in mesoporous silica nanocapsules (SiNC) has recently been demonstrated to be an eco-friendly alternative to decrease biocide toxicity towards marine non-target species. However, the lack of information on the chronic effects of such nanomaterials on non-target tropical species is critical for a more comprehensive environmental risk assessment. Thus, the present study aimed to assess the chronic toxicity and hazard of the soluble and encapsulated forms of DCOIT on neotropical marine species. Chronic tests were conducted with six ecologically relevant species. No effect concentration (NOEC) values were combined with NOEC values reported for tropical species to assess the hazard using the probabilistic approach to derive each predicted no effect concentration (PNEC). The SiNC-DCOIT was three- to ten-fold less toxic than soluble DCOIT. Probabilistic-based PNECs were set at 0.0001 and 0.0097 µg DCOIT L−1 for the biocide soluble and nanostructured forms, respectively. The immobilization of DCOIT into SiNC led to an 84-fold hazard decrease, confirming that the encapsulation of DCOIT into SiNC is a promising eco-friendly alternative technique, even in a chronic exposure scenario. Therefore, the present study will contribute to better management of the environmental risk of such innovative products in the tropical marine environment.
Leakage Detection in Water Distribution Networks Based on Multi-Feature Extraction from High-Frequency Pressure Data
Authors: Wu Xingqi , Peng Sen , Zheng Guolei , Fang Xu , Tian Yimei
Published: March 2023

Leakage detection is an important task to ensure the operational safety of water distribution networks. Leakage characteristic extraction based on high-frequency data has been widely used for leakage detection in experimental networks. However, the accuracy of single-feature-based methods is limited by the interference of background pressure fluctuations in networks. In addition, the setting of leakage diagnosis thresholds has been insufficiently studied, but influences leakage detection performance greatly. Hence, a new method of leakage detection is proposed based on multi-feature extraction. The multi-features of leakage are composed of instantaneous characteristics (ICs) and trend characteristics (TCs), which constitute comprehensive leakage information. The levels of the instantaneous and trend pressure drops in background pressure fluctuations in network environments are quantified for the setting of leakage diagnosis thresholds. In addition, ICs and TCs are used for leakage degree prediction. The proposed method was applied to an experimental network. Compared with the single-feature-based method and the cumulative sum (CUSUM) method, the proposed method achieved increases of 6.01% and 13.66% in F-Scores, respectively, and showed better adaptability to background pressure fluctuations in complex network environments.
Stripping of Cu Ion from Aquatic Media by Means of MgY2O4@g-C3N4 Nanomaterials
Authors: Modwi Abueliz , Idriss Hajo , Khezami Lotfi , Albadri Abuzar , Ismail Mukhtar , Assadi Aymen Amine , Nguyen-Tri Phuong
Published: March 2023

In this study, quaternary MgY2O5@g-C3N4 nanomaterials were produced using a simplistic ultrasonic power technique in the presence of an organic solvent, and their capability to abolish Cu (II) from an aqueous solution was evaluated. As validated by powder X-ray diffraction, the synthesized nanomaterials possessed excellent crystallinity, purity, and tiny crystalline size. According to BET and TEM, the nanomaterials with high porosity nanosheets and perfect active sites made Cu (II) removal from water treatment feasible. At a pH of 3.0, the MgY2O5@g-C3N4 displayed good Cu (II) adsorption capability. The Cu (II) adsorption adhered to the Langmuir adsorption model, with an estimated theoretical maximum adsorption aptitude of 290 mg/g. According to the kinetics investigation, the adsorption pattern best fitted the pseudo-second-order kinetics model. Depending on the FTIR results of the nanocomposite prior to and after Cu (II) uptake, surface complexation and ion exchange of Cu (II) ions with surface hydroxyl groups dominated the adsorption of Cu (II). The MgY2O5@g-C3N4 nanomaterials have great potential as adsorbents for Cu (II) removal due to their easy manufacturing process and high adsorption capacity. Additionally, the reuse of MgY2O4@g-C3N4 nanomaterials was tested through the succession of four adsorption cycles using HNO3. The result showed the good stability of this material for mineral pollution removal.
Effect of Antiscalant Usage and Air Diffuser Perforation Diameter on Filtration Performance of Submerged Flat Sheet MBR for Treatment of High Salinity and Scaling Propensity Wastewater
Authors: Parlar İlker , Jarma Yakubu A. , Pek Taylan O. , Kabay Nalan , Kitis Mehmet , Yigit Nevzat O. , Yuksel Mithat
Published: March 2023

Membrane fouling and mineral scaling remain major drawbacks for MBR technology. Membrane fouling reduces the filtration ability in MBR systems by increasing transmembrane pressure (TMP) and thus increases the operational cost. This study focused on the application of commercially available antiscalant in a pilot MBR system and the effect of diffuser perforation diameter for the treatment of high mineral scaling propensity wastewater. Submerged flat sheet membranes (Kubota, nominal pore size: 0.4 µm) were used in the pilot-scale test unit operated in the wastewater treatment plant of ITOB Organized Industrial Zone, Izmir, Turkey. The commercially available antiscalants employed were coded AS-1 and AS-2 for antiscalant study. Long term effect of the two antiscalants employed was investigated under high mixed liquor suspended solid (MLSS) concentration (17–21 g/L) for two months of MBR operation. The effect of low MLSS concentration (10–13 g/L) was also studied without changing the concentration of antiscalant type and concentration. AS-1 was found to be more effective in terms of mineral scale control. The effect of diffuser perforation diameter (1, 3 and 5 mm) on mineral scaling minimization in MBR pilot system was also studied. The best performance with respect to membrane fouling control was found with an air diffuser having 3 mm of diffuser perforated diameter. Some quality analyses of the product water were also carried out to assess the effect of antiscalant addition on microbial activities in the MBR unit. The findings in this study reveal that the use of antiscalants has not affected biological treatment performance of MBR pilot system. The removal ranges obtained during all MBR studies were 98.47–99.9%, 84.62–99.4%, 89.5–98.5%, 86.90–99.9%, 67.01–99.2%, 75.03–93.9%, and 20.36–71.5% for total suspended solid (TSS), color, chemical oxygen demand (COD), NH4-N, PO4-P, NO2-N, and total nitrogen (TN) respectively.
Energy and Exergy Analysis of Solar Air Gap Membrane Distillation System for Seawater Desalination
Authors: Mibarki Nawel , Triki Zakaria , Belhadj Abd-Elmouneïm , Tahraoui Hichem , Amrane Abdeltif , Cheikh Sabrina , Hadadi Amina , Bouchelkia Nasma , Kebir Mohamed , Zhang Jie , Assadi Amine Aymen , Mouni Lotfi
Published: March 2023

Air gap membrane distillation (AGMD) is a widely utilized technology for producing drinking water due to its low heat loss, high thermal efficiency, and compatibility with solar energy. The application of the first and second laws of thermodynamics in energy and exergy analyses provides a comprehensive evaluation of the efficiency of thermal processes. This study aims to examine numerically the energy and exergy performance indicators of a solar AGMD system used for seawater desalination. The simulation was carried out using MATLAB 9.7 software. The total thermal efficiency and overall efficiency of each element in the AGMD system were calculated for various solar field energy outputs, and moreover, a parametric study was conducted. The results indicate that the exergetic efficiency of the AGMD system components was the lowest in the solar field, with the concentrator having the lowest energy efficiency. Additionally, the thermal and exergetic efficiency of the entire solar AGMD system decreases along with the raise of ambient temperature. An additional investigation was conducted to better apprehend the sources of exergy destruction in the solar field. The obtained results from this study can be employed as a guide to reduce exergy destruction in the whole solar AGMD desalination system with recognition of the main sources of irreversibility.
Mesoporous Zr-G-C3N4 Sorbent as an Exceptional Cu (II) Ion Adsorbent in Aquatic Solution: Equilibrium, Kinetics, and Mechanisms Study
Authors: Khezami Lotfi , Modwi Abueliz , Taha Kamal K. , Bououdina Mohamed , Ben Hamadi Naoufel , Assadi Aymen Amine
Published: March 2023

A mesoporous Zr-G-C3N4 nanomaterial was synthesized by a succinct-step ultrasonication technique and used for Cu2+ ion uptake in the aqueous phase. The adsorption of Cu2+ was examined by varying the operating parameters, including the initial metal concentration, contact time, and pH value. Zr-G-C3N4 nanosorbent displays graphitic carbon nitride (g-C3N4) and ZrO2 peaks with a crystalline size of ~14 nm, as determined by XRD analysis. The Zr-G-C3N4 sorbent demonstrated a BET-specific surface area of 95.685 m2/g and a pore volume of 2.16 × 10−7 m3·g−1. Batch mode tests revealed that removing Cu (II) ions by the mesoporous Zr-G-C3N4 was pH-dependent, with maximal removal achieved at pH = 5. The adsorptive Cu2+ ion process by the mesoporous nanomaterial surface is well described by the Langmuir isotherm and pseudo-second-order kinetics model. The maximum adsorption capacity of the nanocomposite was determined to be 2.262 mol·kg−1 for a contact time of 48 min. The results confirmed that the fabricated mesoporous Zr-G-C3N4 nanomaterial is effective and regenerable for removing Cu2+ and could be a potent adsorbent of heavy metals from aqueous systems.
Integrated Flood Hazard Vulnerability Modeling of Neluwa (Sri Lanka) Using Analytical Hierarchy Process and Geospatial Techniques
Authors: Wijesinghe W. M. D. C. , Mishra Prabuddh Kumar , Tripathi Sumita , Abdelrahman Kamal , Tiwari Anuj , Fnais Mohammed S.
Published: March 2023

This research aimed to apply the geospatial techniques and Analytical Hierarchy Process (AHP) approach to find vulnerable areas in terms of flooding in the Neluwa area, Sri Lanka. The study incorporated nine relevant criteria for the vulnerability classification under three sub-criteria; the built environment, physical environment, and socio-economic environment. Under the built environment, road networks and buildings were chosen as sub-criteria. The Normalized Difference Vegetation Index (NDVI), slope, elevation, water bodies, and stream density were taken as physical criteria. Land use and population density were considered as socio-economic criteria. All the criteria are set correctly in raster data, and their contents were well adduced. The study consisted of the use of different levels of criteria and combinations of different processes. The analytical results reveal that 14.24% and 30.24% of the total area are at a very-high risk and high risk for flooding, respectively. Only 5.17% of the land was classified as a risk-free area. Eastern, central, and western divisions of the study area are highly vulnerable to floods due to their low slopes. Based on the produced maps, the spatial extents and levels of risk were systematically identified. Data obtained through qualitative judgments related to the field were validated based on the approach used. The potential of this approach is effective in assessing the spatial vulnerability of these flood-affected areas. Using such criteria and a model-based approach will be constructive in identifying different flood scenarios and in providing a remunerative guideline for potential anticipatory measures and better land-based planning in the area.
The central administration of the executive power of the Republic of Bulgaria – an unreformed part of the state apparatus system
Authors: Nikolova Raina
Published: March 2023

The present study is dedicated to the essence of the concept of “state apparatus”, to the historical and legal analysis of the formation of the central administrations of the executive power in Bulgaria and its development until the adoption of the current Constitution of the Republic of Bulgaria of 1991. It deals with the legal framework concerning the status of the national central public administration and criticizes its shortcomings. The study presents the development of the central public administration over a period of 30 years (1991–2021).
The COVID-19 pandemic and its effects on crime – consequences and risks
Authors: Smedovska-Toneva Rada
Published: March 2023

The health crisis, due to the COVID-19 attracts the attention of different kinds of experts, including criminologists. This is because the pandemic has affected one of the main research topics of the criminology – the criminality. In the very beginning of the crisis it has turned out that it would radically change the public and social organization which would inevitably influence the criminal tendencies. A few months after the lockdown in most of the countries one of the main research observation is that crime rates have decreased markedly. The pandemic has shown crime is an extremely dynamic social phenomenon capable to adapt quickly to the social changes. However, could we perceive positively this crime drop or should we regard it with sharp attention and have in mind the eventual social consequences and risks?
El camino de la justicia
Authors: Valencia García Duvan Fernando
Published: March 2023

El presente artículo pretende realizar una reflexión sobre la diferenciación entre lo justo y la justicia, a partir de los enfoques interaccional e institucional. Se sustenta teóricamente en dos cuestiones fundamentales, en un primer momento, procura mostrar la imposibilidad de definir la justicia, al considerarla como una noción simple y por lo tanto no definible ni realizable; y en un segundo momento, procura dejar sembrada la diferencia conceptual de la justicia desde la filosofía moral y el enfoque interaccional y la filosofía política y el enfoque interinstitucional, para lograrlo se toman los principales elementos de la moral platónica, de la moral aristotélica y del utilitarismo clásico; asimismo del pensamiento político de John Locke y John Rawls principalmente, para finalmente concluir que la justicia ha de considerarse como una virtud política.
Retorno a la voz
Authors: Fitzgerald Daniel
Published: March 2023

Este artículo estudia los manuscritos inéditos de las clases sobre Oscar Wilde que dictó Jorge Luis Borges en el Colegio Libre de Estudios Superiores entre julio y agosto de 1950. La primera sección muestra un esbozo de la labor docente de Borges en este período y muestra cómo una clase centrada en el discurso de Wilde dio lugar al ensayo “Del culto de los libros” (1951). Las secciones segunda y tercera argumentan que la defensa que hace Borges de la obra de Wilde involucra dos líneas de abordaje, la relación del discurso de Wilde con su obra y un estudio de las justificaciones estéticas del mal. Estas dos líneas convergen en la lectura que Borges hace de Schopenhauer y Wilde. La cuarta sección estudia los apuntes de Borges sobre “The critic as artist”, donde Wilde reclama un “retorno a la voz”. Lo que esto podría implicar se discute a la luz del trabajo de Walter Ong (2012) y la lectura del pragmatismo elaborada por Bruno Bosteels (2007). La última sección rastrea los ecos de estas notas en “La muralla y los libros”.
La ilustre incertidumbre
Authors: Almeida Iván
Published: March 2023

Aunque fueron contemporáneos, Borges y Wittgenstein nunca se conocieron, ni se citaron, ni se leyeron. Pero hay poderosas afinidades y conexiones entre ambos. Por ejemplo, al fin del Tractatus Wittgenstein entiende que hay que callar precisamente ahí porque se ha llegado a un punto en el que conceptual se subordina a lo poético. La idea de que la naturaleza estética del mundo no puede representarse por medio del lenguaje también es característica de Borges. El mar, los atardeceres, la llama de una hoguera, por ejemplo, son la inminencia de una revelación que nunca se produce, son el hecho estético. La obra de Wittgenstein es estrictamente filosófica y al mismo tiempo literaria. Esa proposición parece verdadera también para el caso de la obra de Borges.
Power Apps pada Sistem Pemodelan Pengambilan Obat di Klinik Melia PT. POMI, Paiton
Authors: Primasanti Yunita
Published: March 2023

Digitalization is one of the important keys in increasing productivity, namely by building digital technology that improves process efficiency, product and service quality, and optimizes resource allocation, so as to reduce processing time for faster, streamlined operations, and greater customer satisfaction. as good as Power Apps. Power Apps is a service for building and deploying custom business applications that connect to your data and work across the web and mobile - without the time and expense of specialized software development. Power Apps are a number of applications, services, and connectors, as well as a data platform, that provide a fast development environment for building custom applications for business needs. Using Power Apps, users can quickly create custom business applications that connect to data stored on the base data platform (Microsoft Dataverse) or across various online and on-premises data sources (such as SharePoint, Microsoft 365, Dynamics 365, SQL Server, and so on). The purpose of this study is to implement and analyze the use of Power Apps in modeling drug retrieval at the Melia Clinic PT POMI, Paiton with the aim of improving the quality of Melia clinic services through acceleration and ease of drug taking. The output of this research is an accredited national journal.
Nearshore placement of dredged material for estuarine shoreline restoration in Berkeley Township, New Jersey
Authors: Barone Daniel , Miskewitz Robert , Douglas W. Scott
Published: March 2023

Nearshore placement of sediments for beach nourishment has become a standard, cost-effective method for shore protection along ocean-facing shorelines but is not a widely adopted practice within tidal estuaries due to environmental concerns such as turbidity, burial of benthic and shore organisms, and pollution. This paper describes the monitoring and evaluation of nearshore placement of dredged materials at Goodluck Point, Berkeley Township, New Jersey. A total of approximately 4,500 cubic meters of dredged material was placed in the nearshore to create a parallel bar along a 0.5 km stretch of existing beach. The narrow beach is the front edge of a marsh system severely impacted by erosion due to lack of sediment supply compounded with local currents and waves that transport sediment out of the beach system offshore and alongshore. This beach erosion is exacerbated during coastal storms events. The Goodluck Point marsh is part of the Edwin B. Forsythe Wildlife Refuge managed by the U.S. Fish and Wildlife Service. Nearshore placement was determined to be part of an experimental project designed to evaluate methods of restoration for the marsh and reduce future impacts. The design for the nearshore placement called for sand to be placed in a temporary parallel bar just offshore of the existing beach, and over time it would weld to the beach. Analysis of pre- and post-placement surveys indicate that much of the dredged material placed in the project area remained there throughout the 18-month monitoring period. However, a combination of storms during and after placement, as well as ongoing longshore transport processes, resulted in the sand being washed south along the beach and accumulating in just the southern 200 meters of the project area. This paper introduces and suggests that the concept of “process-based design” will maximize resiliency benefits through more extensive pre-placement monitoring and modeling to identify optimal placement strategies. Process-based design is a beneficial use strategy that takes advantage of natural sediment transport processes to enhance or re-create nature-based shore protection features.
Smoke-free beaches in Florida
Authors: Pierobon John Michael , Leatherman Stephen
Published: March 2023

Beach tourism is often the most important source of revenue for coastal communities, and surveys have shown that the foremost requirements for beachgoers are clean sand and clean water. Beach litter is harmful and costly in many ways, and the No. 1 form of litter on U.S. beaches is cigarette butts. Campaigns for smoke-free beaches have been based largely on environmental issues and aesthetics, but there are other important reasons. Hawaii was the first state to ban smoking on beaches. This paper presents the rationale for Florida cities and counties to adopt smoke-free policies for one of their most important natural resources and recreational destinations.
Ecofeminist and Freedom Theology from Porong: a Study on Poetries Compilation by Children of Lapindo’s Victims
Authors: Andalas Mutiara
Published: March 2023

This paper investigates poetries written by children victims of Lapindo narrating their suffering in speaking against the corporation and government’s indifferent. Those poetries exemplify and amplify the meaning of sisterhood among human being, ecology and its surrounding ecosystem in the tragic way. The children expose greediness as part of contemporary sin in connection to economic dimension. The aggression against women is similar with the aggression against the nature. This paper concludes that intellectus fidei will transform the practice of intellectus liberationem.
When Bulls No Longer Drink Water under Keningar Trees: Women’s Worldview at Mount Merapi
Authors: Candraningrum Dewi
Published: March 2023

Filsafat ekofeminisme telah mulai memasuki lokus perdebatan bagaimana dia memandang hubungan antara identitas manusia dan percakapan antara manusia, binatang dan alam. Sebelumnya dan masih hidup secara permanen dalam pandangan dunia masyarakat modern bahwa binatang dan alam adalah segala sesuatu yang dikaitkan dengan instrumentalisasi perikehidupan manusia. Perikehidupan selalu dikaitkan dengan kemanusiaan. Perikehidupan manusia memutus dirinya pada kebutuhan-kebutuhan dirinya, sandang-pangannya, tanah-rumahnya, dan segala kenyamanan-kenyamanan yang didapat dari alam dan binatang. Binatang adalah piara, alam adalah instrumen sumber daya untuk eksploitasi tanpa mempertimbangkan keberlanjutannya, tanpa mempertimbangkan sirkularitas ekosistem, ketergantungan antara alam, manusia dan binatang. Manusia meletakkan identitas dirinya secara superior di atas kedua elemen tersebut. Manusia tak lagi dapat mewarisi apa-apa yang ada dalam artefak nenek-moyangnya, dari candi-candi purba, yang mewariskan kesatuan dengan alam, dengan binatang, dengan tumbuhan, dengan Riset 132 pohon-pohon. Modernitas dan kapitalisme telah menceraikan manusia dari kesatuan itu: dari keterkaitan, dari kesetaraan, dari aksi kasihsayang, terhadap alam, terhadap binatang, terhadap pohon-pohon.
Faces of Women’s Activists in the Parliament: Achievements and Political Recommendations
Authors: Perdana Aditya
Published: March 2023

This article describes how seven female activists from civil organizations participate in 2004 and 2009 elections. On the frame of the implementation of women’s representation in parliament that has been started since 2004 election, this article unearths women’s representation movement based on the actors’ experiences to participate in election. Using case study method and analysis with process tracing, this article argues that women activists, who participated in two elections, have contributed to implement women’s representation into their political parties and parliament.
Women’s Status in Contemporary Islamic Politics: Tafsir of Al Hurriyah, Al Musawah, Al Karamah and Al Adalah
Authors: Muhammad Husein
Published: March 2023

This paper examines theological sources of Islam on the status of women in Politics. Al Quran states that equality between men and women are guaranteed in politics such as in Quran: Ali Imran, 195; an Nahl, 97; at Taubah, 71. Islamic politics based on the following postulates: first, freedom (al Hurriyyah). Human beings are only serving God. Second, equality (Musawah, non-discriminatory). All human being are equal in front of Allah. Third, respect to other human beings (Karamah al Insan/ preserving the other human’s dignity). Fourth, justice (‘Adalah). Theological sources of Islam has given foundation for the contemporary status of women in politics which had long been stripped away due to misogynistic interpretation of Quran. Quran has ontologically supply equality and justice to human rights that can be used in politics and state affairs.
“Why I founded Our Voice”: a Memoir
Authors: Hartoyo NFN
Published: March 2023

Reformation Era has brought equality to any social movement such as LGBT circle. This era asked and gave opportunity to engage actively in the governance in many ways. Those that entered formal politics, or outside of formal politics such as NGO and community service. LGBT issue is becoming new term in the activism in Indonesia and that is why I established Suara Kita (Our Voice) to celebrate our identity and social justice. This paper narrated the establishment of this organization up to the present time under repression of the society.
Causes or Cures? Sexual Violence against Lesbian, Bisexual and Transgender Female-to-Male in Indonesia
Authors: Yolandasari Ayu Regina
Published: March 2023

Sexual violence is a crime in which the victims are usually blamed for being the cause. When it happened to a cisgender heterosexual woman, many people tend to use her appearance and her behavior to justify the victim blaming. It would even be more complicated for lesbian, bisexual women, or female-to-male transgender (LBT). When sexual violence happened to them, their sexual and/or gender identity tend to be added on the reasons to justify the perpetrators’ actions. Strangely, in contrast to that, this crime is also usually thought as the cause of their being LBT. This paper is aimed to explore this paradoxical thoughts of sexual violence against LBT, its effects on LBT’s lives, and efforts made to break through the paradox itself.
LGBT’s Human Rights in the Indonesian Interior Policies
Authors: Muthmainnah Yulianti
Published: March 2023

Human rights which were convened by international laws and United Nations is at present universally ideal. However in implementation, this universality was contrained by interior politics, soveregnity, religious interpretation, and culture. Issues of LGBT has received wave of protests internationally and nationally though their rights are guaranteed within laws. Include LGBT issue has been debated on the national an local level. On the other hand, state has responsibility to promote, to protect, and to fulfill human rights for every single person, even people with sexual orientation and gender identity from any harms and violences. This paper will explore how human rights in Indonesia interior politics will protect LGBT groups.
Nephrotic Syndrome: Could Personalized Therapy Be Possible? A Review
Authors: Длин В.В. , Морозов С.Л.
Published: March 2023

Термину «персонализированная медицина» чуть более 20 лет, но индивидуальные подходы к терапии пациентов существуют уже более ста лет. Расшифровка генома и развитие фармакогенетики в последние десятилетия открыли новые пути развития медицины и новое понимание понятия «персонализированная медицина». Активное развитие принципов персонализированного подхода к диагностике и лечению в педиатрической нефрологии, особенно с использованием современных молекулярно-генетических методов, не только в разы увеличит диагностические возможности в верификации заболеваний почек, но и позволит определиться с индивидуальной терапией для каждого конкретного ребенка. Это приведет к повышению эффективности лечения, снижению серьезных нежелательных явлений проводимой терапии и существенному улучшению качества жизни, социального и витального прогноза. В статье на примере глюкокортикоидной терапии при нефротическом синдроме у детей продемонстрирована важность изучения генетических факторов, влияющих на индивидуальный фармакодинамический и фармакокинетический профиль глюкокортикостероидов.

The term "personalized medicine" is just over 20 years old, but individual approaches to patient therapy have been around for over a hundred years. Decoding the human genome and pharmacogenetics development in recent decades have opened up new paths for medicine development and a new understanding of the concept of "personalized medicine". An active development of principles for personalized approach to diagnosis and treatment in pediatric nephrology, especially with use of modern molecular genetic methods, would not only multiply diagnostic opportunities in kidney disease verification, but also would allow determining an individual therapy for each particular child. This will lead to improvement of treatment efficacy, to reduction of serious adverse events of therapy applied and to significant improvement of the quality of life and both social and vital prognosis. The article demonstrates the importance of studying genetic factors influencing the individual pharmacodynamic and pharmacokinetic profile of glucocorticosteroids using glucocorticosteroids therapy for nephrotic syndrome in children as an example.
Tropeçando na pré-história
Authors: Sales Viana Maria Somália , Sales Viana Rebeca , de Oliveira Paulo Victor , Cardoso Gina , Chaves Arquimedes , Rodrigues Gabriel
Published: March 2023

Esta é a história de duas irmãs Muito curiosas e inteligentes que Aprenderam algo muito valioso com Um simples tropeço. Embarque nesta aventura e Descubra como os fósseis ajudam a Compreender as mudanças no clima e Nas paisagens do planeta terra! Divulgue este livrinho e, como os Autores da história, estimule o Cuidado com os tesouros do passado.
Preparação para implementação da RDA
Authors: Holanda Paulo Marcelo Carvalho , Lourenço Cintia de Azevedo
Published: March 2023

Este artigo apresenta parte dos resultados de uma dissertação sobre a implementação do RDA. O RDA é o código de catalogação já utilizada por várias bibliotecas de outros países. A preparação para a sua implementação perpassa pela percepção dos catalogares para que se construam subsídios, e sejam criadas estratégias para a sua implementação. O artigo tem como objetivo apontar algumas das principais estratégias internacionais de implementação do RDA, iniciadas e adotadas, por outros países; averiguar a conscientização e o conhecimento dos catalogadores diante de tópicos relacionados à implementação do RDA; bem como, apontar os pontos fortes e fracos destas percepções. A metodologia tem características exploratórias, descritivas e de abordagem da investigação quantitativa e qualitativa. Utilizou-se como técnica de coleta de dados a pesquisa bibliográfica e as entrevistas (semiestruturada) em torno do bloco temático: Preparação para a implementação do RDA referente às questões de pretensão por parte das bibliotecas para a implementação do RDA, grupo de discussão, exemplos de registros em RDA, atualização do software para acomodar o RDA, acesso ao RDA Toolkit e pessoal envolvido das bibliotecas para a implementação, sendo que para análise dos dados, a metodologia de análise de conteúdo. Os resultados apontam para uma menor conscientização dos catalogadores sobre o quadro temático. Conclui-se que existe pretensão e preparação do Sistema de bibliotecas para a implementação mais ainda com pouca eficácia.
Rapid scientific communication in times of pandemic
Authors: Rocha Eduardo Santos Rocha , Araújo Ronaldo Ferreira
Published: March 2023

The research aimed to analyze the online attention received by preprints about covid-19 shared on Twitter between the years 2020 to September 2021. Literature review, document research, content analysis and altmetric analysis procedures were used. The preprints were retrieved from the Dimensions database and classified by thematic categories, with eight being classified in the Clinical Studies category, three in the Others category, 14 in the Prevention category, six in the Transmission category, five in the Treatment – ​​Drugs category and four in the Variants category. 100,968 tweets were registered in the Clinical Studies category, 56,361 in the Others category, 269,347 in the Prevention category, 81,135 in the Transmission category, 61,720 in the Treatment – ​​Drugs category and 57,655 in the Variants category. It was concluded that altmetry has provided a greater understanding of the impact of research on covid-19 and on the debate held in public space about the pandemic and its consequences based on the understanding of online attention directed at these studies.