bluuebunny/crossref_metadata_2025 huggingface dataset:
Memahami Pencatatan Perkawinan di Indonesia dalam Paradigma Hukum Islam Kontemporer
Authors: Aziz Muhammad , Islamy Athoillah
Published: January 2024

The phenomenon of unregistered marriages is still rampant in Indonesia. Regardless of the various reasons that trigger it, empirical facts show that unregistered marriages cause many legal problems, both for the life of the family concerned, society and the state.This quality research in the form of a literature review intends to re-understand the existence of marriage registration in the Islamic legal paradigm through the contemporary sharia maqasid approach conceptualized by Jasser Auda. This research uses a normative-philosophical approach. Primary data of Law No. 1 of 1974 on Marriage and compilation of Islamic Law. Data collection techniques through documentation techniques. Meanwhile, data analysis through reduction, presentation, and verification.  The results showed that the construction of the paradigm of marriage registration rules in Indonesia is in line with the contemporary Islamic legal paradigm that emphasizes holistic legal arguments, namely involving various perspectives, both normative, social, buddhist, developmental and state regulations for the realization of the benefit of marital life. The results showed that the construction of the paradigm of marriage registration rules in Indonesia is in line with the contemporary Islamic legal paradigm that emphasizes holistic legal arguments, namely involving various perspectives, both normative, social, buddhist, developmental and state regulations for the realization of the benefit of marital life. This can be proven through the various paradigms of system philosophy features elaborated by Jasser Auda as a contemporary sharia maqasid approach. The theoretical implication of this research is that a holistic Islamic legal paradigm is needed, namely through multi-perspectives, not a monolithic paradigm in understanding the implications of the benefits of marriage registration rules. The limitations of this study have not examined the Islamic legal arguments of Islamic religious leaders in Indonesia who tend to be apathetic or permissive to the phenomenon of marriage without being registered in society.
Systematic mapping of experimental approaches to studying common mycorrhizal networks
Authors: Lehmann Anika , Rillig Matthias
Published: January 2024

Mycorrhizal fungi can interlink and connect plants in a common mycorrhizal network (CMN). Studying CMNs is challenging due to pathways of material transfer but also plant and mycorrhizal effects that have to be tested and controlled in order to be able to evaluate the presence and magnitude of a specific CMN effect. These controls let to a clear but strict definition of CMN which requires experiments to fulfill specific criteria: at least two plants are connected by the CMN, all plants are mycorrhized, the roots of the connected plants are separated, there is a CMN treatment tested, and the hyphal continuity is tested. Here, we evaluate the evidence base of the CMN research specifically for arbuscular mycorrhiza via a systematic mapping approach. We found that not all studies were testing true CMNs but rather common fungal networks (CFN), including filamentous fungi other than the targeted mycorrhizal fungi. The number of articles conducting experiments on CMNs drops strongly with increasingly stringent fulfillment of the CMN definition. Additionally, there is a focus on lab studies and specific fungal strains; however, researchers have used diverse plant species setups. Also plant, fungal and resource transfer responses are preferentially measured, while microbial community metrics and ecosystem functions and processes are neglected.We see a need to strengthen the CMN evidence base and thus we call for a renewed research effort on CMN, focusing on a whole range of levels of mechanistic resolution (from CFN to CMN with and without hyphal continuity). Additionally, neglected experimental situations (e.g. field studies in general) and microbial community or ecosystem-level responses should be included in future research.
Evaluación del clima organizacional en una institución formadora de docentes desde una perspectiva cuantitativa y cualitativa
Authors: Pérez Reyna León Alejandro
Published: January 2024

El clima organizacional es un factor importante que, de manera reciente, ha tomado auge en su descripción, evaluación e interés por su investigación en las instituciones educativas de nuestro país. Dado que las percepciones que el trabajador tiene de las estructuras y procesos que ocurren en un medio laboral, el comportamiento de un trabajador no sólo es una resultante de los factores organizacionales existentes, también dependerá de la percepción que tenga de esos factores, es entonces que el clima organizacional va a depender de la interacción entre características personales y organizacionales. En este trabajo se aborda el tema desde una perspectiva cuantitativa y cualitativa utilizando los programas (Statgraphics y Atlas.ti) respectivamente, en una escuela formadora de docentes. Se diagnosticaron y determinaron las principales fuentes de conflicto que afectan de manera negativa las relaciones de trabajo, con la finalidad de implementar programas de intervención que mejoren esta condición. Desde la opinión de los docentes se analizan las principales fuentes de conflicto que afectan de manera negativa el clima organizacional para implementar programas de intervención que mejoren esta condición. Dadas las características cambiantes y de subjetividad de esta condición, se resalta la importancia y conveniencia de que su investigación, deba hacerse desde un enfoque mixto, ya que es más completa, se complementa y permite visualizar con mayor profundidad los elementos de análisis.
APLIKASI PRINSIP KEBAJIKAN KANAK-KANAK DALAM KES HADANAH
Authors: Noor Zanariah
Published: January 2024

This article discusses about the principle of the welfare of the children or the best interest of the children in determining custody decisions under Islamic jurisdictions. Although the qualifications of the conflicting parties are a matter of great importance, the welfare of the children is the paramount consideration with the aims protecting the childrens interests. The qualifications' aspects or other matters are examined only insofar as they relate to their welfare. The discussions also evolve regarding irresponsible and neglectful actions committed by the parents denying the rights and welfare of their own children.
Pengaruh Ekstrak Metanol Buah Lakum (Cayratia trifolia L. Domin) terhadap Nilai SGOT dan SGPT Tikus Putih Diinduksi Parasetamol
Authors: Rousdy Diah Wulandari , Wardoyo Elvi Rusmiyanto Pancaning , Wulandari Catur
Published: January 2024

Lakum fruit (Cayratia trifolia L. (Domin)) has secondary metabolite compounds that are beneficial to health, one of which is a hepatoprotector. This study was conducted to prove the potential of hepatoprotective activity of lakum fruit methanol extract based on the value of SGPT and SGOT enzyme. The research method used a pre-posttest randomized control group design with a sample of 35 male rats divided into five treatment groups: solvent control group (CMC 0.5%); positive control group (HEPA-Q®); treatment group extract (0,575; 1,15; 1,725 mg/g BW). The treatment of induction of paracetamol and methanol extract of Cayratia trifolia fruit was carried out for 7 days respectively. The results showed that the dose of 1,15 mg/g BW of Cayratia trifolia fruit methanol extract had the most effective deterioration of SGOT and SGPT values with a percentage reduction of SGOT of 49.3% and SGPT of 51.8% (p <0.05) which approached control positive (HEPA-Q®). Based on the research conducted, methanol extract of Cayratia trifolia fruit has the potential to be hepatoprotective.
Inoculation of Endophytic Bacteria for Increasing Plant Height and Number of Rice Roots (Oryza sativa)
Authors: Fadilah Fari , Rahayu Triastuti , Agustina Putri , Mumpuni Kistantia Elok , Mandiri Listy Hasti , Prayitno Trio Ageng , Sidiq Yasir
Published: January 2024

Four endophytic bacteria have been isolated from banana kluthuk plants and banana ambon. Previous study showed that they produce Indole Acetic Acid (IAA). This study aimed to analyze the effect of endophytic bacterial inoculation on plant height and the number of rice root. For this reason, two endophytic bacteria of each klutuk banana and ambon banana plants were cultured and examined for growth rate using a 600 nm spectrophotometer. Isolate growth was calculated every two hours for 16 hours of bacterial growth in NB media. Bacterial inoculation experiments on rice plants were carried out with five replications. This inoculation begun with germination of rice seeds until the radicle was observed. Then germinated rice seedlings were soaked in a bacterial suspension for 1 hour at room temperature. The results showed the exponential phase of all isolates was observed at 6 hours with shaking. Inoculation using A22 and A51 isolates significantly increases plant height, number of leaves. While, A22 isolate significantly increased the number of roots compared to the uninoculated plants (control). It supports the potential of endophytic bacteria from banana kluthuk and ambon plants.
Infeksi Malaria dan Status Gizi Balita Pasca Gempa
Authors: Tatontos Erlin Yustin , Urip Urip
Published: January 2024

After the earthquake that occurred on Lombok Island during August 2018, malaria appeared again, especially in West Lombok Regency. The number of cases recorded was 753 people infected with malaria, including babies and pregnant women. Problems that arose after the earthquake on Lombok Island among babies and toddlers were malnutrition, including Insufficient Breast Milk (IBM) and Complementary Foods (CF) due to separation from their mothers. The aim of this research was to determine malaria infection and nutritional status of children under five in the earthquake-affected area in West Lombok Regency. The research method uses a qualitative approach. Data collection used was in-depth interviews, observation, and document study. Data analysis with the Epi info test. The results obtained were that the number of cases of malaria infection in the earthquake-affected areas in West Lombok Regency, especially the Penimbung Community Health Center, in 2018 was 753 cases and in 2019 there were 299 cases. Nutritional status in 2018 and 2019: 5,775 people with good nutrition: 710 people with poor nutrition, and 6 people with Low Birth Weight (LBW). The conclusion that can be drawn is that there is no relationship between post-earthquake malaria and the nutritional status of children under five.
Studi Pustaka : Ekstraksi dan Potensi Utilitasasi Ekstrak Komponen Bioaktif Tanaman Murbei di Indonesia
Authors: Yuniati Yuyun
Published: January 2024

Mulberry is one of the plants that grows well in Indonesia, and has been used to support daily economic activities. Mulberries are of interest to researchers as research objects, regarding the bioactivity of mulberry plants. Over the past decade, from 2013 to 2023, research has been carried out regarding mulberries in Indonesia, with the aim of extracting and analyzing the extract substances. Data from 12 local research journals is known regarding the use of mulberry roots, stems and leaves to be extracted and applied for compound identification purposes, a study of the extraction methods used, and the specific purpose of mulberry extract as a preservative, patch formulation material, as well as an antibacterial agent, preservative, and antioxidants. The mulberry extraction procedures used are the maceration method, wave-based extraction (microwave and ultrasonic) and water bath energy. Qualitative analysis testing of mulberry extract substances was carried out to determine the content of alkaloids, tannins and terpenoid compounds. Quantitative analysis testing of mulberry extract substances was carried out to measure antioxidant activity, anthocyanin levels, and the biological activity of mulberry extract substances.
The Effectiveness of An Internet of Things (IoT)-based Virtual Science Laboratory on Nervous System Material in Science Course
Authors: Atmojo Setyo Eko , Wardana Ari Kusuma , Muhtarom Taufik
Published: January 2024

This study aims to test the effectiveness of the Internet of Things (IoT)-based virtual science laboratory on nervous system material in science lectures. The research method used was an experiment with a pretest-posttest control group design, with the research subjects being randomly selected A3 and A4 class students in the PGRI Yogyakarta University PGSD study program who take science courses. Data was collected by giving a pre-test and post-test and measuring n-gain to determine the increase in concept understanding after using a virtual science laboratory. Data analysis was carried out using the t-test to test the significant difference between the pre-test and post-test results and the n-gain test to measure the effectiveness of virtual science laboratories in improving students' concept understanding. The results of this study indicated that the Internet of Things (IoT)-based virtual science laboratory on nervous system material effectively improves students' understanding of concepts. It can be seen from the average n-gain result of 0.72 in the experimental group, which shows a high increase in concept understanding. The t-test results showed a significant difference between the control group and the experimental group in terms of the effectiveness of the IoT-based virtual science laboratory on nervous system material.
SIKASIH (Sistem Informasi Kejadian Siswa Terkasih) As A Learning Development Based on Overcoming Toxic Behavior on Social Media
Authors: Somantri Asep Risman , Malihah Elly , Nurbayani Siti
Published: January 2024

This research aims to describe in more depth students' experiences in dealing with toxic behaviour on social media then the researchers created a learning model based on handling toxic behaviour on social media. This research used a qualitative approach with descriptive methods because this research describes a realistic view of the social world experienced by the resource person so that this experience can then be used as a reference for researchers in developing a learning model based on handling toxic behaviour on social media. The subjects of this research involved 1200 students in the Bandung Regency area. The data collection techniques were observation, document analysis, and in-depth interviews. The data analysis technique refered to interactive model data analysis, while the data validity technique is triangulation. The findings showed that students' responses in dealing with toxic behaviour experience difficulties because there were no clear rules. So, starting from this experience, the SIKASIH model is created as a learning model based on handling toxic behaviour on social media.
RESTRICTIONS ON ACCESS TO PUBLIC INFORMATION IN THE NATIONAL SECURITY INTERESTS, THREE-PART TEST
Authors: SHYNKAR TETIANA , KUDINOV SERGIY , TALALAI DMYTRO , PONOMARENKO ANNA , PAVLIUTIN YURII , KRAVCHUK PETRO
Published: January 2024

The relevance of the topic is the need to form a modern model of national security protection, taking into account the human rights of access to public information. The conflict of topics lies in the inheritance of legal provisions for obtaining public information by every citizen and the possibility of using such information for personal or commercial purposes. To determine the tools for restricting access to information that may harm national security and national interests, it is customary to use various methods to create a quality environment for information circulation. From such positions, there is a need to conduct a study on modern tools for restricting access to public information to preserve state sovereignty and support the national security strategy. The use of restriction of access to public information is a key principle of strategic development of the countries of the world. In the context of geopolitical threats in the modern world, building an effective strategy to protect the country is a priority. The purpose of the article is to study the essence of restrictions on public information and the possibility of their implementation in the modern legal space. With the help of such approaches, it is worth using the tools to implement the preservation of national interests and preserve the right of citizens to access public information. The objective of the study is to determine the optimal distribution of the parity of the problem of citizensʼ rights to public information and the need to limit them. An important direction in the research is the use of modern tools and methodology to identify key aspects of the subject and the possibility of their improvement under the strategic policy of the country. By using a set of analytical tools and methods, a study on restrictions on access to public information in the interests of national security was conducted. The methodology of the study is the possibility of using modern means of search systematic analysis of the practice of providing and restricting access to public information. The results obtained can improve the quality of state policy-making on the development of national security interests through an optimal policy of providing access to public information. The article investigates the key principles of the development of trends in the restriction of access to public information and describes the main tools for their implementation.
Cinematic Rehearsals of Phenomenology: On the Ontic-Ontological Schema and Heideggerian Film Theory
Authors: Rhym John
Published: January 2024

This article argues that the strengths and problems of Shawn Loht's Phenomenology of Film: A Heideggerian Account of the Film Experience (2017) are rooted in its method, which derives from a specific interpretation of Heidegger's existential analytic and from the critical strategy implemented by Heidegger – and thus later adopted by his readers and applied to various disciplinary domains – in his polemical engagement with the history of philosophy. Central to this method is what I refer to as the ontic-ontological schema, and the article maps out the ways in which it operates in Loht's book: how it shapes his critical intervention into film studies and his claims about film ontology and spectatorship. My argument is that the ontic-ontological schema, while allowing the author to make interesting inroads into debates in film-philosophy, nonetheless undermines the coherence and efficacy of his claims about the cinematic experience as well as his attempts to mobilize these claims in the analysis of specific films. That is, Loht's disciplinary application of the ontic-ontological schema makes for a compelling discursive polemic, but it also exposes a crucial conceptual incompatibility in the work's configuration of and navigation between ontology, aesthetics, and criticism.
Pelatihan Membangun Merek dengan Pemasaran yang Berorientasi pada Manusia Sebagai Daya Tarik pada Ikatan Remaja RW 07 Margonda, Depok, Provinsi Jawa Barat
Authors: Basudani Wahid Akbar , Abdullah Muhammad , Zuniarti Ida , Simamora Valentine Theresia
Published: January 2024

This Community Service activity aims to provide training for teenagers who are members of the RW 007 Margonda Youth Association organization, Depok, West Java, where these teenagers need knowledge about how to build a brand in entrepreneurship. Current developments in the era of digitalization mean that consumers can communicate easily by social media, which requires business owners to build a brand that is human-oriented. Building a brand that is oriented towards humans as customers can be done by understanding consumers through social listening, netnography and empathic research methods. By knowing the concept of building a human-oriented brand, these teenagers can easily capture consumer responses and innovate products according to their customers' needs.
Two Major Conjectures on Prime Numbers
Authors: Vega Frank
Published: January 2024

The Riemann hypothesis is a conjecture that the Riemann zeta function has its zeros only at the negative even integers and complex numbers with real part $\frac{1}{2}$. It is considered by many to be the most important unsolved problem in pure mathematics. In addition, the Cram{\'e}r's conjecture states that $q_{n+1}-q_{n}=O((\log q_{n})^{2})$, where $q_{n}$ denotes the nth prime number, $O$ is big $O$ notation, and $\log$ is the natural logarithm. Let $\Psi(n) = n \cdot \prod_{q \mid n} \left(1 + \frac{1}{q} \right)$ denote the Dedekind $\Psi$ function where $q \mid n$ means the prime $q$ divides $n$. Define, for $n \geq 3$; the ratio $R(n) = \frac{\Psi(n)}{n \cdot \log \log n}$. Let $N_{n} = 2 \cdot \ldots \cdot q_{n}$ be the primorial of order $n$. There are several statements equivalent to the Riemann hypothesis. We state that if the inequality $R(N_{n+1}) < R(N_{n})$ holds for all primes $q_{n}$ (greater than some threshold), then the Riemann hypothesis is true and the Cram{\'e}r's conjecture is false. In this note, using our criterion, we prove that the inequality always holds for all primes $q_{n}$ (greater than some threshold).
PELATIHAN KETERAMPILAN SENI MENGHIAS MEDIA DENGAN TEKNIK DECOUPAGE ART PADA KELOMPOK WANITA PURNAKRAMA MARANATHA MALANG
Authors: Wardani Tri Istining , Rachmi Asminah , Sudjanarti Dwi , Khabibah Umi , Pribadi Joni Dwi , Yanuarni Erma
Published: January 2024

This community service aims to enrich and encourage the entrepreneurial creativity of the target audience in order to empower their skills. Participants in this community service activities are the members of the group of “Purnakrama GSJA - Maranatha Malang”, in which consist of women who are struggling to live alone as widows or unmarried. They live independently and are responsible for their own well-being without the support of a husband or partner. Empowering the participants' skills is delivered by introducing and teaching them the decoupage art technique, that is the art of decorating plain objects/used items with deco-napkins so that the value of the object will increase greatly. After attending this training, participants are expected to stimulate their creativity, as well increase their knowledge and skills, with the result it can be used to help their welfare even though they have to live independently. Decoupage art is chosen a main training topic as it provide a lot of beneficial advantages. Besides it can be easily taught in an efficient time, it also being able to transform used/plain items into more valuable ones because decoupage art have a variety of interesting motifs. Apart from that, the tools and materials used for decoupage art really easy to look for, and the costs are affordable. The competencies have been achieved, as in the end each of the participants has been successfully applied decoupage art technique using two kinds of deco-napkins patterns towards two different medias surfaces, in which each media need special and different treatment to apply decoupage technique. The first media is strap-plastic bag with its rough surface, then another media is flower pot which has smooth surface. In the end, the final evaluation results declared that community service using Decoupage art has been success to empower the members of the group of “Purnakrama GSJA - Maranatha Malang”
PEMBUATAN WEBSITE UNTUK SOSIALISASI PROGRAM DAN BERITA PELAKSANAAN KEGIATAN PADA YAYASAN BUMI LANGGAT PEDULI
Authors: Yoppy Yunhasnawa  , Toga Aldila Cinderatama  , Moch. Zawaruddin Abdullah  , Gunawan Budiprasetyo  , Muhammad Afif Hendrawan  , Candra Bella Vista  , Rinanza Zulmy Alhamri  , Maskur Maskur
Published: January 2024

Yayasan Bumi Langgat Peduli, based in Dusun Langgat, Malang, is a community initiative since 2017, focusing on social development. With funding sources from donors and the "Bongkar-Rapikan-Sedekahkan" program, the foundation has conducted various inclusive programs. However, manual communication via WhatsApp limits the reach of information. Through the Community Engagement project, we from Politeknik Negeri Malang design, implement, and deploy an official website that not only expands the information reach but also effectively showcases the foundation's programs and activities. This endeavor encapsulates a comprehensive solution to enhance Yayasan's outreach and impact.
Plant-mediated synthesis of silver nanoparticles: unlocking their pharmacological potential–a comprehensive review
Authors: Dhir Rajan , Chauhan Sakshi , Subham Praddiuman , Kumar Saksham , Sharma Pratham , Shidiki Amrullah , Kumar Gaurav
Published: January 2024

In recent times, nanoparticles have experienced a significant upsurge in popularity, primarily owing to their minute size and their remarkable ability to modify physical, chemical, and biological properties. This burgeoning interest can be attributed to the expanding array of biomedical applications where nanoparticles find utility. These nanoparticles, typically ranging in size from 10 to 100 nm, exhibit diverse shapes, such as spherical, discoidal, and cylindrical configurations. These variations are not solely influenced by the manufacturing processes but are also intricately linked to interactions with surrounding stabilizing agents and initiators. Nanoparticles can be synthesized through physical or chemical methods, yet the biological approach emerges as the most sustainable and eco-friendly alternative among the three. Among the various nanoparticle types, silver nanoparticles have emerged as the most encountered and widely utilized due to their exceptional properties. What makes the synthesis of silver nanoparticles even more appealing is the application of plant-derived sources as reducing agents. This approach not only proves to be cost-effective but also significantly reduces the synthesis time. Notably, silver nanoparticles produced through plant-mediated processes have garnered considerable attention in recent years due to their notable medicinal capabilities. This comprehensive review primarily delves into the diverse medicinal attributes of silver nanoparticles synthesized using plant-mediated techniques. Encompassing antimicrobial properties, cytotoxicity, wound healing, larvicidal effects, anti-angiogenesis activity, antioxidant potential, and antiplasmodial activity, the paper extensively covers these multifaceted roles. Additionally, an endeavor is made to provide an elucidated summary of the operational mechanisms underlying the pharmacological actions of silver nanoparticles.
Sequence lithofacies paleogeography evolution of the Middle Permian Maokou Formation in the northwest margin of the Sichuan Basin
Authors: Yang Wenjie , Tan Xiucheng , Tang Dahai , Zhang Zhaokun , Hu Xin , Li Minglong , Zeng Zixuan , Xiao Di
Published: January 2024

Due to the present tectonic and stratigraphic distribution characteristics in the northwest margin of the Sichuan Basin are complex, which restricts the understanding of sequence lithofacies paleogeography of the Middle Permian Maokou Formation. To investigate the process of tectonic–sedimentary evolution, basin-margin outcrop and intra-basin well and seismic data were used. The results show two structural sequences, namely, SSQ1 and SSQ2, and five third-order sequences, namely, SQ1–SQ5, in the Middle Permian Maokou Formation. SSQ1, with stable formation thickness, shows a slow transgression–fast regression sequence structure. SSQ2 shows a fast transgression–slow regression sequence structure in the area with large thickness and a sustained transgression–fast regression sequence structure in the area with small thickness owing to thickness differentiation caused by tectonic subsidence. Sedimentological analysis shows that sequences SQ1–SQ2 mainly consist of carbonate-ramp sediments, the sedimentary facies of which change from intermediate ramp to outer ramp as the area depressed topographically from south to north. Sequences SQ3–SQ5 mainly consist of rimmed carbonate platform sediments; the platform margin turned up along Shuangyushi–Jian’ge–Yuanba, and the region to the north subsided rapidly to form slope-basin facies. Lithofacies paleogeography in the Middle Permian epoch shows that the northwest margin of the Sichuan Basin was dominated by extensional stresses in northeast and northwest directions. Tectonic activities have a dominant control on the distribution of two structural sequences and the evolution of carbonate platform types in the Maokou Formation, and the sea-level change has a dominant control on third-order sequence boundaries and sedimentary facies migration. Thus, the Middle Permian tectono-sedimentary evolution model of the northwest margin of the Sichuan Basin is established. Research findings may offer new ideas and theoretical support to promising facies exploration in the Maokou Formation in the northwest margin of the Sichuan Basin.
Obesity and its impact on female reproductive health: unraveling the connections
Authors: Zheng Lei , Yang Lixian , Guo Ziru , Yao Nan , Zhang Shiyu , Pu Pengpeng
Published: January 2024

In the modern era, the escalating global prevalence of obesity has profound implications on female reproductive health. Obesity, transcending mere lifestyle choices, has evolved into a complex disorder affecting physiological and metabolic functions. Concurrently, female infertility is rising as a significant global health issue. Obesity, with its extensive systemic effects, is pinpointed as a major disruptor. The convergence of these health challenges reveals a multifaceted scenario: on one hand, obesity directly impacts female reproductive health, particularly in the context of conditions like polycystic ovary syndrome (PCOS) and menstrual disturbances; on the other, the psychosocial consequences of infertility might intensify weight-gain patterns, forming a challenging cycle. Additionally, the economic implications of treating obesity-related infertility are considerable. This review delves into the myriad ways obesity affects female reproductive health, drawing insights from epidemiological, clinical, and molecular studies. It explores the epidemiological relationship between obesity and PCOS, the influence of obesity on menstrual disturbances, and the broader impact of obesity on female infertility. Weight loss, through pharmacological interventions, surgical methods, or lifestyle adjustments, emerges as a promising strategy. Lastly, the efficacy of assisted reproductive technologies, such as IVF, is influenced by obesity, underscoring the importance of an optimal body mass index. The review also highlights the molecular and physiological mechanisms underlying the impact of obesity on female reproductive health, including the disruption of the hypothalamic-pituitary-ovary axis, altered adipokine secretion, and the role of chronic inflammation and oxidative stress.
Decentralized asynchronous adaptive federated learning algorithm for securely prediction of distributed power data
Authors: Li Qiang , Liu Di , Cao Hui , Liao Xiao , Lai Xuanda , Cui Wei
Published: January 2024

Introduction: Improving the precision and real-time speed of electricity data prediction while safeguarding data privacy and security holds immense significance for all power system participants’ decision-making. To surmount the issues of exorbitant computational expenses and privacy breaches of traditional centralized prediction methods, this paper proposes a decentralized asynchronous adaptive federated learning algorithm for securely prediction of distributed power data, which makes predictions from distributed data more flexible and secure.

Methods: First, each regional node trains its own deep neural network model locally. After that, the node model parameters are uploaded to the decentralized federated learning chain for ensuring local data protection. Asynchronous aggregated update of the global prediction model is then achieved via block mining and shared maintenance. The algorithm has been enhanced based on the traditional federated learning algorithm, which introduces an asynchronous mechanism while adaptively adjusting the regional node model weights and local update step size to overcomes the inefficiency of traditional methods.

Results and Discussion: The experimental analysis of actual electricity price data is conducted to compare and analyze with the centralized prediction model, study the impact of model adoption and parameter settings on the results, and compare with the prediction performance of other federated learning algorithms. The experimental results show that the method proposed in this paper is highly accurate, efficient, and safe.
Understanding spatio-temporal variation of autumn phenology in temperate China from 1982 to 2018
Authors: Wu Shuai , Wu Wei
Published: January 2024

Land surface phenology plays a crucial role in accurately parameterizing interactions between land ecosystems and the atmosphere. Changes in autumn phenology directly impact the length of vegetation growing season and year-to-year changes in carbon uptake. Previous studies have often focused solely on the end of growing season when characterizing autumn phenology, neglecting the onset and duration of autumn. Here, we extracted the annual autumn phenological metrics, i.e., the start of brown-down phase (SOB), the end of brown-down phase (EOB), and the length of brown-down phase (LOB), for temperate China from 1982 to 2018 based on our self-developed global LSP dataset. We conducted a comparative analysis of SOB, EOB, and LOB in the field of their spatial distribution, temporal trends, and performance on various categories of vegetated regions (i.e., forests, grasslands, croplands, and vegetated areas in urban lands (V_Urban)). The results showed a significant negative correlation between the timing of autumn phenological metrics and latitude in temperate China. Between 1982 and 2018, there were significant positive increasing trends in EOB and LOB in V_Urban, as well as in LOB in forests in temperate China. However, the annual mean SOB, EOB, and LOB did not show significant trends across the entire study area. At the local pixel scale, SOB, EOB, and LOB exhibited a combination of advanced and delayed trends within various vegetated categories. The trends of the same phenological metric were not uniform across these diverse vegetated regions. For instance, the majority of pixels with significant trends in SOB exhibited delayed trends in forests and croplands, while displaying advanced trends in grasslands and V_Urban. In this study, employing three metrics (SOB, EOB, and LOB) to describe autumn phenology enhances our understanding of the impacts of global climate change on ecosystems, offering a more comprehensive and detailed perspective. In the future, satellite-based monitoring and phenological modeling should contemplate incorporating additional potential phenological metrics.
Development of a prognostic Neutrophil Extracellular Traps related lncRNA signature for soft tissue sarcoma using machine learning
Authors: Liu Binfeng , He Shasha , Li Chenbei , Li Zhaoqi , Feng Chengyao , Wang Hua , Tu Chao , Li Zhihong
Published: January 2024

Background

Soft tissue sarcoma (STS) is a highly heterogeneous musculoskeletal tumor with a significant impact on human health due to its high incidence and malignancy. Long non-coding RNA (lncRNA) and Neutrophil Extracellular Traps (NETs) have crucial roles in tumors. Herein, we aimed to develop a novel NETsLnc-related signature using machine learning algorithms for clinical decision-making in STS.

Methods

We applied 96 combined frameworks based on 10 different machine learning algorithms to develop a consensus signature for prognosis and therapy response prediction. Clinical characteristics, univariate and multivariate analysis, and receiver operating characteristic curve (ROC) analysis were used to evaluate the predictive performance of our models. Additionally, we explored the biological behavior, genomic patterns, and immune landscape of distinct NETsLnc groups. For patients with different NETsLnc scores, we provided information on immunotherapy responses, chemotherapy, and potential therapeutic agents to enhance the precision medicine of STS. Finally, the gene expression was validated through real-time quantitative PCR (RT-qPCR).

Results

Using the weighted gene co-expression network analysis (WGCNA) algorithm, we identified NETsLncs. Subsequently, we constructed a prognostic NETsLnc signature with the highest mean c-index by combining machine learning algorithms. The NETsLnc-related features showed excellent and stable performance for survival prediction in STS. Patients in the low NETsLnc group, associated with improved prognosis, exhibited enhanced immune activity, immune infiltration, and tended toward an immunothermal phenotype with a potential immunotherapy response. Conversely, patients with a high NETsLnc score showed more frequent genomic alterations and demonstrated a better response to vincristine treatment. Furthermore, RT-qPCR confirmed abnormal expression of several signature lncRNAs in STS.

Conclusion

In conclusion, the NETsLnc signature shows promise as a powerful approach for predicting the prognosis of STS. which not only deepens our understanding of STS but also opens avenues for more targeted and effective treatment strategies.
Causal role of immune cells in generalized anxiety disorder: Mendelian randomization study
Authors: Ma Zhen , Zhao Min , Zhao Huanghong , Qu Nan
Published: January 2024

Background

Generalized anxiety disorder (GAD) is a prevalent emotional disorder that has received relatively little attention regarding its immunological basis. Recent years have seen the widespread use of high-density genetic markers such as SNPs or CNVs for genotyping, as well as the advancement of genome-wide association studies (GWAS) technologies, which have facilitated the understanding of immunological mechanisms underlying several major psychiatric disorders. Despite these advancements, the immunological basis of GAD remains poorly understood. In light of this, we aimed to explore the causal relationship between immune cells and the disease through a Mendelian randomization study.

Methods

The summary information for GAD (Ncase=4,666, Ncontrol=337,577) was obtained from the FinnGen dataset. Summary statistics for the characterization of 731 immune cells, including morphological parameters (MP=32), median fluorescence intensity (MFI=389), absolute cells (AC=118), and relative cells (RC=192), were derived from the GWAS catalog. The study involved both forward MR analysis, with immune cell traits as the exposure and GAD as the outcome, and reverse MR analysis, with GAD as the exposure and immune cell traits as the outcome. We performed extensive sensitivity analyses to confirm the robustness, heterogeneity, and potential multi-biological effects of the study results. Also, to control for false positive results during multiple hypothesis testing, we adopted a false discovery rate (FDR) to control for statistical bias due to multiple comparisons.

Results

After FDR correction, GAD had no statistically significant effect on immunophenotypes. Several phenotypes with unadjusted low P-values are worth mentioning, including decreased PB/PC levels on B cells(β=-0.289, 95%CI=0.044~0.194, P=0.002), reduced PB/PC AC in GAD patients (β=-0.270, 95% CI=0.77~0.92, P=0.000), and diminished PB/PC on lymphocytes (β=-0.315, 95% CI=0.77~0.93, P=0.001). GAD also exerted a causal effect on CD27 on IgD-CD38br (β=-0.155,95%CI=0.78~0.94,P=0.002), CD20-%B cell (β= -0.105,95% CI=0.77~0.94, P=0.002), IgD-CD38br%lymphocyte(β=-0.305, 95%CI=0.79~0.95, P=0.002), FSC-A level on granulocytes (β=0.200, 95%CI=0.75~0.91, P=8.35×10−5), and CD4RA on TD CD4+(β=-0.150, 95% CI=0.82~1.02, P=0.099). Furthermore, Two lymphocyte subsets were identified to be significantly associated with GAD risk: CD24+ CD27+ B cell (OR=1.066,95%CI=1.04~1.10,P=1.237×10−5),CD28+CD4+T cell (OR=0.927, 95%CI=0.89~0.96, P=8.085×10−5).

Conclusion

The study has shown the close association between immune cells and GAD through genetic methods, thereby offering direction for future clinical research.
Risk factors for postpartum hemorrhage in twin pregnancies with cesarean section
Authors: Lan Yehui , Xu Anjian , Lu Xinyue , Zhou Yujia , Wang Jianping , Hua Ying , Dong Ke
Published: January 2024

The rates of twin pregnancies and cesarean section have increased in recent years, and both of them are at high risks of postpartum hemorrhage (PPH). However, few studies have concentrated on the risks of PPH in twin pregnancies and cesarean deliveries. In this study, we aimed to identify the risk factors for PPH among twin-pregnant women with cesarean section. This was a retrospective observational study including 1,649 women with twin pregnancies delivered by cesarean section from 2016 to 2022 in the Second Affiliated Hospital of Wenzhou Medical University, China. The eligible women were divided into PPH group (n = 116) and non-PPH group (n = 1,533) according to the blood loss after delivery within 24 h. The baseline maternal and perinatal characteristics were compared between the two groups. Logistic regression analysis was conducted to identify the potential risk factors for PPH. We found nulliparity, assisted reproductive technology (ART) usage, preeclampsia or HELLP syndrome, placenta previa, placenta accreta and general anesthesia were more common in PPH group than non-PPH group (P < 0.05). Women in PPH group had higher maternal body mass index at delivery and higher combined birthweight of the twins than non-PPH group, but had lower parity (P < 0.05). Seven independent risk factors for PPH were identified after logistic regression analysis: ART usage (OR 2.354 95% CI 1.357–4.083, P = 0.002), preeclampsia or HELLP syndrome (OR 2.605, 95% CI 1.471–4.616, P = 0.001), placenta previa (OR 7.325, 95% CI 3.651–14.697, P < 0.001), placenta accreta (OR 6.296, 95% CI 1.316–30.12, P = 0.021), thrombocytopenia (OR 1.636, 95% CI 1.056–2.535, P = 0.027), general anesthesia (OR 2.394, 95% CI 1.223–4.686, P = 0.011), and combined birthweight (OR 1.00032, 95% CI 1.00005–1.00059, P = 0.020). Collectively, in women with twin pregnancies delivered by cesarean section, the use of ART, preeclampsia or HELLP syndrome, placenta previa, placenta accreta, thrombocytopenia, general anesthesia and the combined birthweight were identified as independent risk factors for PPH. More attention should be paid to women with these risk factors.
Lactobacillus plantarum MH-301 as an effective adjuvant to isotretinoin in the treatment of acne vulgaris: a randomized and open-label trail
Authors: Liang Lili , Qi Xinyue , Jiang Xiaoke , Chen Tingtao , Dong Lina
Published: January 2024

Introduction

Acne vulgaris is a common chronic inflammatory skin disease originating in the sebaceous gland units of the skin follicles. Isotretinoin is presently the primary choice for the treatment of acne vulgaris. However, it could induce several adverse reactions like diarrhea, cheilitis, headache, elevated triglyceride levels and risk of inflammatory bowel disease and depression. Hence, it is imperative to seek an alternative therapy.

Methods

One hundred five patients were randomly divided into 3 groups, and received a baseline treatment of oral doxycycline for the initial 4 weeks. Group I received isotretinoin oral for 12 weeks; Group P received oral Lactobacillus plantarum MH-301 treatment for 12 weeks; Group IP received combined treatment with oral probiotics and oral isotretinoin for 12 weeks. The number of skin lesions was recorded at 0, 4, 8, and 12 weeks during the treatment to compare the efficacy of each intervention, and skin and fecal samples were collected from patients at 12 weeks for high-throughput sequencing to explore the microbiota differences between various groups.

Results

Our results revealed that the combination of L. plantarum MH-301 with isotretinoin significantly reduced the number of skin lesions in patients compared to using L. plantarum MH-301 and isotretinoin alone (p < 0.001). Additionally, skin microbiome High-throughput analysis indicated the restorative effects of L. plantarum MH-301 on skin microbial diversity while also observing a reduction in the main microbiota of skin lesions, Propionibacterium and Corynebacterium. Meanwhile, gut microbiome High-throughput analysis showed that it could regulate disorders of the intestinal microbiota and increased the abundance of probiotics such as Lactobacillus, Bifidobacterium, Coprococcus and Bacteroides genera.

Conclusion

In conclusion, L. plantarum MH-301 could be used in combination with isotretinoin for optimal results in the treatment of acne vulgaris. The research conducted provides theoretical and data support for the adjuvant effect of L. plantarum in the treatment of acne vulgaris.

Clinical Trial Registration

[ClinicalTrials.gov], identifier (ChiCTR2200063499).
Multi-omics revealed the effects of dietary energy levels on the rumen microbiota and metabolites in yaks under house-feeding conditions
Authors: Ma Xiaoyong , La Yongfu , Yang Guowu , Dai Rongfeng , Zhang Juanxiang , Zhang Yonghui , Jin Jiaming , Ma Xiaoming , Guo Xian , Chu Min , Yan Ping , Zhang Qiang , Liang Chunnian
Published: January 2024

Yak (Bos grunniens) is a unique large ruminant species in the Qinghai-Tibetan Plateau (QTP). Changing the energy levels of their rations can significantly improve their growth performance. Therefore, studying the effects of dietary energy levels on the rumen microflora and metabolites of yak is crucial for enhancing the development of the yak industry. Currently, there is a lack of understanding regarding the impact of feeding energy diets on rumen fermentation parameters, microbial functions, and metabolites. This study was designed to determine the appropriate energy level for feeding yak. Three test diets with metabolizable energy levels of 7.57 MJ/kg, 9.44 MJ/kg, and 11.9 MJ/kg were used and the concentration of volatile fatty acids (VFA) in rumen fluid was measured. The microbial communities, functions, and metabolites in yaks were studied by 16S rRNA sequencing, metagenome, and LC-MS non-targeted metabolomics to investigate the relationships among rumen fermentation parameters, microbial diversity, and metabolites. Ration energy levels significantly affect total VFA, acetate, propionate, butyrate, iso-valerate, valerate, and acetate/propionate (p < 0.05). At the phylum level, the dominant phyla in all three treatment groups were Bacteroidota, Firmicutes, and Actinobacteriota. At the genus level, the abundance of the unclassified_o__Bacteroidales, norank_f_Muribaculaceae, Lachnospiraceae_NK4A136_group, and Family _XIII_AD3011_group showed significant differences (p < 0.05) and were significantly correlated with differential metabolites screened for phosphatidylcholine [PC(16:0/0:0), PC(18:3/0:0)], uridine 3′-monophosphate, and adenosine monophosphate, etc. CAZymes family analysis showed that GHs and CEs differed significantly among the three groups. In addition, differential metabolites were mainly enriched in the pathways of lipid metabolism, nucleotide metabolism, and biosynthesis of other secondary metabolites, and the concentrations of differential metabolites were correlated with microbial abundance. In summary, this study analyzed the effects of ration energy levels on rumen microorganisms and metabolites of yaks and their relationships. The results provided a scientific basis for the selection of dietary energy for yaks in the house feeding period in the future.