bluuebunny/crossref_metadata_2025 huggingface dataset:
Function, Innervation, and Neurotransmitter Signaling in Mice Lacking Type-II Taste Cells
Authors: Larson Eric D. , Vandenbeuch Aurelie , Anderson Catherine B. , Kinnamon Sue C.
Published: January 2020

TheSkn-1atranscription factor (Pou2f3) is required for Type II taste cell differentiation in taste buds. Taste buds inSkn-1a-/-mice lack Type II taste cells but have a concomitant expansion of Type III cells, providing an ideal model to determine the relative role of taste cell types in response specificity. We confirmed that chorda tympani responses to sweet, bitter, and umami stimuli were greatly reduced in the knock-outs (KOs) compared with wild-type (WT) littermates.Skn-1a-/-mice also had reductions to NaCl that were partially amiloride-insensitive, suggesting that both Type II and Type III cells contribute to amiloride-insensitive salt detection in anterior tongue. We also confirmed that responses to sour stimuli are equivalent in the KOs, despite the large increase in the number of Type III taste cells. To examine their innervation, we crossed theHtr3a-GFP (5-HT3A-GFP) reporter mouse with theSkn-1a-/-mice and examined geniculate ganglion neurons for GFP expression and responses to 5-HT. We found no change in the number of 5-HT3A-expressing neurons with KO ofSkn-1a. Calcium imaging showed that only 5-HT3A-expressing neurons respond to exogenous 5-HT, while most neurons respond to ATP, similar to WT mice. Interestingly, despite loss of all Type II cells, the P2X3 antagonist AF353 blocked all chorda tympani responses. These data collectively raise questions pertaining the source of ATP signaling in the absence of Type II taste cells and whether the additional Type III cells are innervated by fibers that would have normally innervated Type II cells.
Interneuron Transplantation Rescues Social Behavior Deficits without Restoring Wild-Type Physiology in a Mouse Model of Autism with Excessive Synaptic Inhibition
Authors: Southwell Derek G. , Seifikar Helia , Malik Ruchi , Lavi Karen , Vogt Daniel , Rubenstein John L. , Sohal Vikaas S.
Published: January 2020

Manipulations that enhance GABAergic inhibition have been associated with improved behavioral phenotypes in autism models, suggesting that autism may be treated by correcting underlying deficits of inhibition. Interneuron transplantation is a method for increasing recipient synaptic inhibition, and it has been considered a prospective therapy for conditions marked by deficient inhibition, including neuropsychiatric disorders. It is unknown, however, whether interneuron transplantation may be therapeutically effective only for conditions marked by reduced inhibition, and it is also unclear whether transplantation improves behavioral phenotypes solely by normalizing underlying circuit defects. To address these questions, we studied the effects of interneuron transplantation in male and female mice lacking the autism-associated gene,Pten, in GABAergic interneurons.Ptenmutant mice exhibit social behavior deficits, elevated synaptic inhibition in prefrontal cortex, abnormal baseline and social interaction-evoked electroencephalogram (EEG) signals, and an altered composition of cortical interneuron subtypes. Transplantation of wild-type embryonic interneurons from the medial ganglionic eminence into the prefrontal cortex of neonatalPtenmutants rescued social behavior despite exacerbating excessive levels of synaptic inhibition. Furthermore, transplantation did not normalize recipient EEG signals measured during baseline states. Interneuron transplantation can thus correct behavioral deficits even when those deficits are associated with elevated synaptic inhibition. Moreover, transplantation does not exert therapeutic effects solely by restoring wild-type circuit states. Our findings indicate that interneuron transplantation could offer a novel cell-based approach to autism treatment while challenging assumptions that effective therapies must reverse underlying circuit defects.

SIGNIFICANCE STATEMENTImbalances between neural excitation and inhibition are hypothesized to contribute to the pathophysiology of autism. Interneuron transplantation is a method for altering recipient inhibition, and it has been considered a prospective therapy for neuropsychiatric disorders, including autism. Here we examined the behavioral and physiological effects of interneuron transplantation in a mouse genetic model of autism. They demonstrate that transplantation rescues recipient social interaction deficits without correcting a common measure of recipient inhibition, or circuit-level physiological measures. These findings demonstrate that interneuron transplantation can exert therapeutic behavioral effects without necessarily restoring wild-type circuit states, while highlighting the potential of interneuron transplantation as an autism therapy.
Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis and agranulocytosis in a patient with Graves’ disease
Authors: Tomkins Maria , Tudor Roxana Maria , Smith Diarmuid , Agha Amar
Published: January 2020

This case is the first to describe a patient who experienced concomitant agranulocytosis and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis as an adverse effect of propylthiouracil treatment for Graves’ disease. A 42-year-old female with Graves’ disease presented to the emergency department (ED) with a 2-week history of fevers, night sweats, transient lower limb rash, arthralgia, myalgia and fatigue. She had been taking propylthiouracil for 18 months prior to presentation. On admission, agranulocytosis was evident with a neutrophil count of 0.36 × 109/L and immediately propylthiouracil was stopped. There was no evidence of active infection and the patient was treated with broad-spectrum antibodies and one dose of granulocyte colony-stimulation factor, resulting in a satisfactory response. On further investigation, ANCAs were positive with dual positivity for proteinase 3 and myeloperoxidase. There was no evidence of end-organ damage secondary to vasculitis, and the patient’s constitutional symptoms resolved completely on discontinuation of the drug precluding the need for immunosuppressive therapy.

Learning points:

Continued vigilance and patient education regarding the risk of antithyroid drug-induced agranulocytosis is vital throughout the course of treatment.

ANCA-associated vasculitis is a rare adverse effect of antithyroid drug use.

Timely discontinuation of the offending drug is vital in reducing end-organ damage and the need for immunosuppressive therapy in drug-induced ANCA-associated vasculitis.

Similarities in the pathogenesis of agranulocytosis and drug-induced ANCA-associated vasculitis may offer insight into an improved understanding of vasculitis and agranulocytosis.
Mitochondrial stress protein HSP60 regulates ER stress-induced hepatic lipogenesis
Authors: Xiao Ting , Liang Xiuci , Liu Hailan , Zhang Feng , Meng Wen , Hu Fang
Published: January 2020

Endoplasmic reticulum (ER) stress and mitochondrial dysfunction are associated with hepatic steatosis and insulin resistance. Molecular mechanisms underlying ER stress and/or mitochondrial dysfunction that cause metabolic disorders and hepatic steatosis remain to be fully understood. Here, we found that a high fat diet (HFD) or chemically induced ER stress can stimulate mitochondrial stress protein HSP60 expression, impair mitochondrial respiration, and decrease mitochondrial membrane potential in mouse hepatocytes. HSP60 overexpression promotes ER stress and hepatic lipogenic protein expression and impairs insulin signaling in mouse hepatocytes. Mechanistically, HSP60 regulates ER stress-induced hepatic lipogenesis via the mTORC1-SREBP1 signaling pathway. These results suggest that HSP60 is an important ER and mitochondrial stress cross-talking protein and may control ER stress-induced hepatic lipogenesis and insulin resistance.
Glutamine-induced signaling pathways via amino acid receptors in enteroendocrine L cell lines
Authors: Nakamura Takumi , Harada Kazuki , Kamiya Taichi , Takizawa Mai , Küppers Jim , Nakajima Kazuo , Gütschow Michael , Kitaguchi Tetsuya , Ohta Kunihiro , Kato Tadafumi , Tsuboi Takashi
Published: January 2020

Glucagon-like peptide-1 (GLP-1), secreted by gastrointestinal enteroendocrine L cells, induces insulin secretion and is important for glucose homeostasis. GLP-1 secretion is induced by various luminal nutrients, including amino acids. Intracellular Ca2+ and cAMP dynamics play an important role in GLP-1 secretion regulation; however, several aspects of the underlying mechanism of amino acid-induced GLP-1 secretion are not well characterized. We investigated the mechanisms underlying the L-glutamine-induced increase in Ca2+ and cAMP intracellular concentrations ([Ca2+]i and [cAMP]i, respectively) in murine enteroendocrine L cell line GLUTag cells. Application of L-glutamine to cells under low extracellular [Na+] conditions, which inhibited the function of the sodium-coupled L-glutamine transporter, did not induce an increase in [Ca2+]i. Application of G protein-coupled receptor family C group 6 member A and calcium-sensing receptor antagonist showed little effect on [Ca2+]i and [cAMP]i; however, taste receptor type 1 member 3 (TAS1R3) antagonist suppressed the increase in [cAMP]i. To elucidate the function of TAS1R3, which forms a heterodimeric umami receptor with taste receptor type 1 member 1 (TAS1R1), we generated TAS1R1 and TAS1R3 mutant GLUTag cells using the CRISPR/Cas9 system. TAS1R1 mutant GLUTag cells exhibited L-glutamine-induced increase in [cAMP]i, whereas some TAS1R3 mutant GLUTag cells did not exhibit L-glutamine-induced increase in [cAMP]i and GLP-1 secretion. These findings suggest that TAS1R3 is important for L-glutamine-induced increase in [cAMP]i and GLP-1 secretion. Thus, TAS1R3 may be coupled with Gs and related to cAMP regulation.
Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway
Authors: Wu Fang-Ju , Wang Ying-Wen , Luo Ching-Wei
Published: January 2020

Bone morphogenetic proteins (BMPs) are known to play an indispensable role in preventing the precocious luteinization of granulosa cells within growing ovarian follicles. In this study, we found that the transcripts of BMP8 genes are enriched in the ovaries of humans and rodents. When analyzing transcriptomic datasets obtained from human mature granulosa cells, we further found that the BMP8 transcripts not only show the highest abundance among the searchable BMP-related ligands but also decrease significantly in women of advanced age or women with polycystic ovarian syndrome. The correlation between the BMP8 levels in granulosa cells and the decline in ovarian function in these subjects suggests that BMP8 protein may be involved in the regulation of granulosa cell function(s). Using a rat model, we demonstrated that human BMP8A protein activates the SMAD1/5/8 and the SMAD2/3 pathways simultaneously in both immature and mature granulosa cells. Furthermore, the expression of potential type I and type II receptors used by BMP8 in rat granulosa cells was characterized. We found that BMP8A treatment can significantly inhibit gonadotropin-induced progesterone production and steroidogenesis-related gene expression in granulosa cells. Pathway dissection using receptor inhibitors further revealed that such inhibitory effects occur specifically through the BMP8-activated SMAD1/5/8, but not SMAD2/3, pathway. Taken together, considering its abundance and possible functions in granulosa cells, we suggest that BMP8 may act as a novel luteinization inhibitor in growing follicles.
Revisiting PI3-kinase signalling in angiogenesis
Authors: Kobialka Piotr , Graupera Mariona
Published: January 2020

PI3Ks belong to a family of lipid kinases that comprises eight isoforms. They phosphorylate the third position of the inositol ring present in phosphatidylinositol lipids and, in turn, activate a broad range of proteins. The PI3K pathway regulates primal cellular responses, including proliferation, migration, metabolism and vesicular traffic. These processes are fundamental for endothelial cell function during sprouting angiogenesis, the most common type of blood vessel formation. Research in animal models has revealed key functions of PI3K family members and downstream effectors in angiogenesis. In addition, perturbations in PI3K signalling have been associated with aberrant vascular growth including tumour angiogenesis and vascular malformations. Together, this highlights that endothelial cells are uniquely sensitive to fluctuations in PI3K signalling. Here, we aim to update the current view on this important signalling cue in physiological and pathological blood vessel growth.
New artery of knowledge: 3D models of angiogenesis
Authors: Zucchelli Eleonora , Majid Qasim A , Foldes Gabor
Published: January 2020

Angiogenesis and vasculogenesis are complex processes by which new blood vessels are formed and expanded. They play a pivotal role not only in physiological development and growth and tissue and organ repair, but also in a range of pathological conditions, from tumour formation to chronic inflammation and atherosclerosis. Understanding the multistep cell-differentiation programmes and identifying the key molecular players of physiological angiogenesis/vasculogenesis are critical to tackle pathological mechanisms. While many questions are yet to be answered, increasingly sophisticated in vitro, in vivo and ex vivo models of angiogenesis/vasculogenesis, together with cutting-edge imaging techniques, allowed for recent major advances in the field. This review aims to summarise the three-dimensional models available to study vascular network formation and to discuss advantages and limitations of the current systems.
Heroes in Lithuania: Aspect of (De-)Heroization, Case, Approach
Authors: Sviderskytė Gražina Kristina
Published: January 2020

In this article, I explore a tendency of (de-)heroization in Lithuania during the 20th century. This research is focused on a historical hero, that is, a mental construct based on a historical prototype: a protagonist of the factual versus fictional narrative who was idealized, mythologized, and initiated to meet the current collective needs and demands. The aim can be generalized by the following questions: who is a historical hero and why is he important; what makes (de-)heroization relevant and how did/does it occur; why this phenomenon is relevant to Lithuania and how should it be further explored? The applied methodology involved a case study (an analysis of the transforming and transfigured heroes, the origin and evolution of the heroic narrative about Lithuanian-American pilots Stephen William Darius and Stanley [Thomas] Girch, aka Darius and Girėnas), a discourse analysis, and an interdisciplinary approach focusing on the heroism humanities in the context of the emerging transdisciplinary heroism science. The emergence and specificity of the heroic ideals – the Great Lithuanian and Winged Lithuanian – and types – the Warrior and Aviator – is explored, and the tendency of idealization and ideologization as well as inertia and stagnation in heroization processes are revealed. The resilience of the cult of power, as well as ideological relics of Lithuanian nationalism and even Soviet utopianism in the current heroism discourse, has led to an unsettling conclusion that the process of hero-making simultaneously and repeatedly involved an exalted idealization and deep depreciation of the heroic figures and their original ideas and/or achievements and of the historical past and historical heritage in general. This kind of (de-)heroization was an integral part of the construction of the Lithuanian mythical modernity.
Corpora and Translation. Are Corpora Still an Academic Luxury?
Authors: Grigaliūnienė Jonė
Published: January 2020

This paper aims to consider the impact corpora have made on language studies and to touch upon the interface between corpora use and translator training/practice. A small-scale survey conducted among the translation trainers/professionals and translation students, with the aim of finding out whether professional translators and students are aware of the existence of corpora and to what extent they use them in their work, revealed that both the trainers and the students are well aware of corpora, but they still prefer translation memory technology to using corpora when translating. They have also pointed out that they would be interested in a service which quickly provided domain-and-language specific corpora tailored to their needs and a tool for extracting terminology from a domain specific corpus. The paper presents a tool which is now widely available for academic institutions in Europe and which gives a chance to quickly and easily compile a specific corpus, extract keywords, provides concordances and gives a useful word sketch that could be of great help when translating. The paper concludes that corpora have yet to make an impact on translation studies and that this will depend on raising awareness of the usefulness of corpora for translation training and practice and the availability of corpora tools that could meet translator needs.
The Stylistic Uses of Gothic Passive Constructions
Authors: Ratkus Artūras
Published: January 2020

This paper explores the variation between non-past (present and future) synthetic and periphrastic passive verb forms in the Gothic Gospels in an effort to evaluate the possibility that the availability of functionally identical forms of the passive was exploited by the translators of the Gothic Bible as a way of manipulating the stylistic composition of the Gothic text. Based on the evidence of the Gothic translation of the Gospels, although the Gothic synthetic passive constructions do mostly occur in stylistically special environments, the existence of other clearly verifiable competing motivations makes the stylistic motivations difficult to verify. It is concluded that the distribution of forms is largely determined by factors such as literalism as the main translation technique as well as contrasts between the synthetic and periphrastic ‘be’ passives in terms of the actionality of the former and stativity of the latter.
Problems Encountered in the Process of Translation and their Possible Solutions: The Point of View of Students of Technical Translation
Authors: Roskoša Antra , Rūpniece Diāna
Published: January 2020

This research investigates the opinions of novice translators–35 students of the Institute of Applied Linguistics, in Bachelor’s and Master’s Programmes of Technical Translation at Riga Technical University–regarding the problems encountered while translating. Data for the research were drawn from the students’ essays and then explored using content analysis. According to the views of technical translation students, knowledge of the type and nature of translation problems helps the translator solve them and provide adequate, quality translations.
Aksara Jawi dalam Naskah Sarana Walio
Authors: Inayatusshalihah Inayatusshalihah
Published: January 2020

Abstract Buton was a maritim sultanate in Southeast Sulawesi. It had a strategic location because it was a centre of transit and trade in Nusantara and Asia. This situation caused cultural contact and arose new Butonese culture. A kind of cultural product is literate tradition using such as Jawi script (Arabic-Malay) that appeared from interaction of local culture, the Butonese, with islam. In history of Buton many kitab was writen in Jawi script including Kitab Sarana Walio. Taking descriptive-qualitative method, the writer analyze Jawi script that was used in Sarana Walio text. This analyze was related with cultural context that underlied the appearance of this script. This research has found the system of writing with Jawi script in this manuscript. Based on ortographic system, Jawi script in Sarana Walio is not different from ortography of Arabic-Malay system in Nusantara. Graphem consist of consonant and vocal which is symbolized by huruf saksi, not punctuation. Meanwhile, there’s inconsistence in the case of word writing in manuscript. ---Abstrak Buton merupakan kesultanan maritim di Sulawesi Tenggara yang memiliki letak strategis karena menjadi pusat persinggahan dan perdagangan Nusantara dan Asia. Hal ini tentu saja menyebabkan terjadinya kontak budaya yang memunculkan bentuk-bentuk kebudayaan baru di masyarakat Buton. Salah satunya adalah tradisi tulis aksara Jawi (Arab-Melayu) yang lahir dari interaksi budaya lokal masyarakat Buton dengan Islam. Banyak kitab dalam sejarah Buton yang ditulis dalam aksara Jawi, di antaranya Kitab Sarana Walio. Dengan menggunakan metode deskriptif-kualitatif, penulis mengkaji aksara Jawi dalam teks Sarana Walio, dihubungkan dengan konteks budaya yang melatari munculnya aksara tersebut. Penelitian telah menemukan adanya sistem penulisan aksara Jawi dalam naskah tersebut. Ditinjau dari ortografinya, aksara Jawi dalam Sarana Walio tidak berbeda dengan sistem ejaan Arab-Melayu pada umumnya di Nusantara. Grafem terdiri atas grafem konsonan dan grafem vokal yang dilambangkan dengan huruf saksi, tidak dengan tanda baca. Selain itu, ada inkonsistensi penyalin naskah dalam penulisan beberapa kata.DOI: 10.15408/al-turas.v23i1.4794
Description of vowel in the first grammatical work of Tamil and Arabic: A contrastive analysis
Authors: Sundararaj D.
Published: January 2020

Abstract Tolkāppiyam and Al-Kitāb, these two grammatical texts are belonging to two different languages Tamil and Arabic. Tamil is a Dravidian family and Arabic is a Semitic family with different writing systems (Tamil-left to right; Arabic-right to left).  These two grammatical texts are written in different historical period, Tolkāppiyam written in BC 300 and Al-Kitāb written in AD 800. Both are describes the vowels of respective language through different phonetic features. The main aim of this paper is to evaluate and analyze the articulatory treatment of vowels in the perspective of first grammatical work of respective languages. The first section of the paper is evaluating the articulatory treatment, theory, classification and phonetic frameworks of vowels in respective grammars, and the second section analyzing in contrastive and describes the commonness and differences between these two texts. This section finds out the commonness in the following features: articulatory treatment, descriptive and use of technical terms etc. The differences are found in the following features: order of the description of speech sounds, method of classification of vowels etc. ---AbstrakTolkāppiyam dan Al-Kitab adalah dua teks gramatikal yang menggunakan dua bahasa yang berbeda, yakni Tamil dan Arab. Ditinjau dari aspek rumpun bahasa, Tamil merupakan keluarga bahasa Dravida, sedangkan Arab adalah keluarga bahasa Semit. Sistem penulisan kedua bahasa itu berbeda bahasa Tamil memiliki sistem penulisan dari arah kiri ke kanan; sedankgan bahasa Arab memakai sistem penulisan dari arah kanan ke kiri. Kedua teks tata bahasa itu ditulis dalam periode sejarah yang berbeda, Tolkāppiyam ditulis dalam SM 300 dan Al-Kitab yang ditulis dalam AD 800. Keduanya menunjukkan vokal bahasa masing-masing, melalui fitur fonetik yang berbeda. Tujuan utama dari artikel ini adalah untuk mengevaluasi dan menganalisis cara artikulasi vokal dalam perspektif  tata bahasa, bahasa itu. Bagian pertama dari tulisan ini mengevaluasi cara  artikulasi, teori, klasifikasi dan kerangka fonetik yang menunjukkan bunyi-bunyi vokal dalam tata bahasa masing-masing, dan bagian analisis kedua dilakukan tinjauan aspek kontrastif dan menggambarkan secara umum persamaan dan perbedaan antara dua teks tersebut. Pada kesempatan ini dipaparkan secara umum beberapa fitur antara lain: cara artikulasi, deskripsi dan penggunaan istilah teknis. Bertumpu kepeda beberapa fitur itu terdapat perbedaan yang ditemukan dalam fitur itu, yaknit: urutan deskripsi suara pidato, metode klasifikasi vokal dan beberapa fitur lainnya.DOI: 10.15408/al-turas.v23i1.4808
How Influences on Residency Choice Change Through Medical School
Authors: Greco Lisa , Koehler Sharon L , Blazey William , Pino Maria A
Published: January 2020

This article was migrated. The article was not marked as recommended. Purpose: To attract medical students (MS) to primary care, administrators must understand what impacts students to select a certain area of medicine. This study elucidates these influences and how they change throughout four years. Methods: A survey was administered to first-year (Group-I) and fourth-year (Group-II) MS at New York Institute of Technology College of Osteopathic Medicine (NYIT-COM). Questions sought to understand what factors influence student's residency choice. Results: There were 258 respondents, 184 responses (71.0%) were from Group-I and 75 (29.0%) were from Group-II. Academic performance and board scores had a greater impact on career choice for Group-I (83.2%) than Group-II (13.3%). Perceived status among colleagues had a greater negative influence on Group-II (13.7 %) than Group-I (2.90 %). Opportunity to care for patients and their families had an increased negative influence on Group-II (11.1%) than Group-I (0.6 %). Conclusions: Upon entering medical school, academic performance had a greater influence on residency choice than it did 4th year after exams were completed. Compared to 1st year MS, the ability to care for patients and families, with perceived status among colleagues is a deterring factor to 4th year MS choice of residency.
Drug use influence on mindfulness among nursing students
Authors: Seleghim Maycon Rogério , Gherardi-Donato Edilaine Cristina da Silva
Published: January 2020

ABSTRACT Objective: To assess the association between the presence of drug use and the dimensions of mindfulness in a population of students of technical education in nursing. Method: Correlational study conducted in a teaching institution in the inlands of the state of São Paulo, in 2017. Participants were 135 students for which the ASSIST questionnaire with personal characterization data and the Mindfulness Five-facet Questionnaire were applied. Data were analyzed with use of descriptive and analytical statistics. Results: The most used drugs were alcohol, tobacco and cannabis. The lowest score for mindfulness was 49 and the maximum was 171 points. There was a positive association between the presence of drugs in the three previous months and the “non-reactivity to internal experience” facet (p=0.004). Conclusion: Although the association seems to be in line with the precepts of mindfulness, this fact cannot be considered positive if analyzed separately from the other concepts of mindfulness. Descriptors: Mindfulness; Substance Use Disorders; Nursing Students; Technical Education in Nursing; Mental Health.
INNOVATION IN EMERGING MARKETS: THE ROLE OF ABSORPTIVE CAPACITY AND OF THE INSERTION IN THE LOCAL AND GLOBAL VALUE CHAINS
Authors: CALEGARIO CRISTINA L. L. , BRUHN NÁDIA C. P. , FIGUEIRA MARIANE , ALCÂNTARA JUCIARA N.
Published: January 2020

ABSTRACT Objective: The objective of this study is to identify the effects of the insertion in local and global value chains as a determinant of company innovation, identifying the main characteristics of the nature of the interactions that arise in the value chain, as well as the relationship between innovation, internal resources to the company and their insertion in value chains. Originality/value: This paper combines insights from different streams of literature to develop a more comprehensive framework for the analysis of firms’ innovation in emerging countries. We consider relationships among partners in the local and global value chain and the influence of the internal resources as crucially important for the access to external knowledge. Design/methodology/approach: Econometric analysis were performed using generalized linear models (GLM). The period of analysis covers the years 1998 to 2011. We investigate our hypotheses using different models to relate firms’ innovation capacity to local and global value chains and the ownership of internal and external resources. Findings: Using data from Brazilian firms from 1998 to 2011, we found that the relationship with all partners in global value chain contributed to the increase of the Brazilian firm’s innovation. The internal resources had a positive influence in firm’s innovation, suggesting that the firm’s internal resources are crucially important in the access to external knowledge, which means that the ability of firms to make use of this knowledge depends, in turn, on their absorptive capacity.
Construcción de una red de ontologías sobre eventos meteorológicos a partir de periódicos históricos
Authors: VILCHES-BLÁZQUEZ Luis Manuel , COMESAÑA Diana , ARRIETA MORENO Lorena de Jesús
Published: January 2020

Resumen En la actualidad, pocos niegan el valor del contenido del periódico para comprender cuestiones relacionadas con la política, cultura y sociedad. De esta manera, la digitalización de los archivos de periódicos ha permitido rescatar artículos históricos y culturales relevantes. Sin embargo, aún no se ha sacado a la luz una infinidad de “datos menores” que se encuentran ocultos en estos periódicos. En este artículo se afrontan los desafíos para acceder y tratar los fondos de las hemerotecas nacionales de Colombia, Ecuador, México y Uruguay, que recogen noticias sobre eventos meteorológicos entre los siglos XIX-XX. Sobre estos periódicos se conforma un corpus de noticias que mediante lecturas técnicas y la aplicación de un proceso de bibliominería, utilizando diversas herramientas, permite iniciar la construcción de una red de ontologías. Esta red se compone de diferentes módulos (técnico, general y noticias), que son construidos utilizando diferentes enfoques (top-down y bottom-up) y metodologías (Methontology y NeOn), con el fin de proveer un entendimiento común y compartido de los eventos meteorológicos históricos en Latinoamérica. Por tanto, este trabajo supone un acercamiento de los fondos de las hemerotecas/bibliotecas a la Web Semántica.
Estabilidade dimensional de moldes obtidos com alginato de armazenamento tardio
Authors: CALMON Janyne Dourado Quintão , RELVAS Adriano , LEFRANÇOIS Mauro , AZEVEDO Marcos Venício , SOTELO Pablo , SOTELO Laura
Published: January 2020

Resumo Introdução Recentemente, vêm surgindo no mercado alguns alginatos de armazenamento prolongado. Não há, no entanto, um consenso na literatura a respeito da estabilidade dimensional destes materiais durante este armazenamento Objetivo Avaliar, por meio de método prático experimental, a estabilidade dimensional de um alginato de armazenamento tardio. Material e método O material de moldagem utilizado foi o alginato Hydrogum 5 (Zhermack). Uma matriz metálica cilíndrica foi utilizada para a realização das moldagens, com 38 mm de diâmetro externo, 30 mm de diâmetro interno e cuja superfície superior apresenta três linhas paralelas entre si com 25 mm de comprimento e 20, 50 e 75 µm de largura. Após o tempo de geleificação do material de moldagem, 16 moldes foram colocados em um umidificador e essas amostras foram fotografadas utilizando-se uma câmera digital (Canon EOS Rebel 3Ti, Canon) associada a um software para análise das imagens obtidas (ImageJ 1.52a, U.S. National Institutes of Health; DI). A calibragem da régua foi 10 cm e, posteriormente, três linhas foram medidas três vezes, para se obter uma média dos comprimentos das linhas. As amostras foram fotografadas nos seguintes intervalos: imediatamente, 24, 48, 72, 96 e 120 horas. Resultado Os dados mostraram diferenças estatisticamente significantes para o fator tempo quando comparada a leitura imediata com os demais períodos de tempo de leitura (p<0,001) e quando comparada a leitura após 24 h de armazenagem com os demais períodos de tempo (p<0,001). Não houve diferença estatística (p>0,05) quando os tempos de armazenamento de 48 h, 72 h, 96 h e 120 h foram comparados entre si. Todos os valores encontravam-se dentro dos valores preconizados pela ISO 21563:2013. Conclusão Os moldes dos alginatos testados podem ser armazenados por até cinco dias em 100% de umidade relativa.
CHARACTERIZATION OF RHIZOBIA AND ARBUSCULAR MYCORRHIZAL FUNGI IN AREAS IMPACTED BY GRAVEL MINING IN BRAZIL
Authors: SILVA FELIPE FERREIRA DA , SANTOS THAINÁ ALVES DOS , JESUS EDERSON DA CONCEIÇÃO , CHAER GUILHERME MONTANDON
Published: January 2020

ABSTRACT On-shore oil exploration is one of the main economic activities in the semiarid region (Caatinga biome) of the state of Rio Grande do Norte (RN), Brazil. Gravel mining is an activity associated with oil exploration that causes environmental impacts. Gravel is a base-material for constructions, such as roads and pumpjack bases. The areas of gravel mining and other decommissioned areas where the gravel has been deposited must be revegetated with species native to the biome at end of the activity in the site. An efficient strategy for revegetation of degraded areas has been the planting of leguminous species that can associate with rhizobia and arbuscular mycorrhizal fungi (AMF). Nevertheless, the impact of mining activities on the autochthonous populations of these microorganisms is unknown. The objective of the present work is to characterize the density of rhizobia and AMF spores in four areas impacted by the oil exploration in RN when compared to non-impacted adjacent areas. Gravel samples were collected in dry and rainy seasons in two mining areas: one in a pumpjack base, and one in a waste disposal area. Surface soil (topsoil) samples were collected in adjacent areas with native Caatinga vegetation. Assays were carried out to evaluate the most probable number (MPN) of rhizobia and to identify the type and density of arbuscular mycorrhizal fungi (AMF), using rhizobia trap plants Mimosa tenuiflora (Mart.) Benth. and Mimosa caesalpiniifolia Benth. The MPN of rhizobia was low in all areas, but higher in the rainy season. The highest amount and diversity of AMF spores were found in the dry season. Among the symbiotic microorganisms studied, the AMF presented lower densities in the evaluated areas when compared to those in the adjcent native vegetation areas, denoting the impact of this activity.
MORPHOLOGY AND PRODUCTION OF WEST INDIAN CHERRY IRRIGATED WITH SALINE WATERS UNDER COMBINATIONS OF NITROGEN-POTASSIUM FERTILIZATION
Authors: SILVA EVANDRO MANOEL DA , GHEYI HANS RAJ , NOBRE REGINALDO GOMES , BARBOSA JOICY LIMA , SOUZA CRISTIANE MILENNE ALVES DE
Published: January 2020

ABSTRACT Fertilization management is one of the technologies studied to reduce nutritional imbalance in plants submitted to saline stress. In this context, we analyzed the effect of the combination of nitrogen and potassium fertilization on the morphology and production of West Indian cherry irrigated with saline waters in the first year of cultivation. The experiment was carried out in the CCTA/UFCG, in 60-L lysimeters installed in the field, in a randomized block design and 5 x 4 factorial scheme, referring to five levels of irrigation water salinity (ECw), i.e., 0.3, 1.3, 2.3, 3.3, and 4.3 dS m-1, and four combinations (C) of nitrogen-potassium fertilization, i.e., C1 = 70% N + 50% K2O; C2 = 100% N + 75% K2O; C3 = 130% N + 100% K2O, and C4 = 160% N + 125% K2O of the recommended dose for West Indian cherry, with three replicates and one plant per plot consisting of a lysimeter. The cv. ‘Flor Branca’, grafted on cv. Junco, was studied. The combination of fertilization with 70% N + 50% K2O promoted higher morphology and production values and mitigated the effect of salinity on fruit diameter up to an ECw of 1.3 dS m-1. Nitrogen-potassium fertilization in the combination of 130% N + 100% K2O impaired plant morphology and production. The ECw above 0.3 dS m-1 decreased the stem diameter, size, and average weight of fruits of West Indian cherry in the first year of cultivation.
USE OF VEGETABLE OILS TO CONTROL BEAN WEEVIL DEVELOPMENT ON COWPEA GRAINS
Authors: WANDERLEY MARIA JOSÉ ARAÚJO , COSTA NIVÂNIA PEREIRA DA , SILVA THATIANA MARIA BORGES , CRUZ GEORGE RODRIGO BELTRÃO DA , MELO THIAGO DE SOUSA
Published: January 2020

ABSTRACT Callosobruchus maculatus, commonly known as cowpea weevil, is the main pest affecting stored cowpea Vigna unguiculata. The damage resulting from the penetration and feeding of cowpea weevil larvae within the grains or seeds of V. unguiculata leads to weight loss, reduction of germination power and nutritional value and commercial depreciation of this plant. The objective of this work was to evaluate the insecticidal activity and repellency of vegetable oils extracted from fennel, citronella, neem and 'moringa' against C. maculatus adults. To evaluate the insecticidal activity, we placed 20 adult insects in plastic containers lined with filter paper impregnated with different doses (0.0 x 106, 5.0 x 106, 1.0 x 105, 1.5 x 105, 2.0 x 105, 3.05, 4.0 x 105 and 5.0 x 105 L) of each vegetable oil. The number of insects was analyzed 24 hours later. To evaluate the repellency activity, we used an arena formed by five circular plastic containers with the central container interconnected symmetrically to the others by plastic tubes arranged diagonally. Samples of 30 g of cowpea were impregnated with different doses (5.0 x 106, 1.0 x 105, 1.5 x 105 and 2.0 x 105 L) of each vegetable oil. We released 50 adults of C. maculatus in the central container and counted the number of insects per container 24 hours later. Citronella and fennel oils at a dose of 3.0 x 105 L demonstrated a higher insecticidal effect on C. maculatus. However, citronella oil presented the best repellent action.
GENETIC DISSIMILARITIES BETWEEN FAVA BEAN ACCESSIONS USING MORPHOAGRONOMIC CHARACTERS
Authors: GONÇALVES GABRIEL DE MORAES CUNHA , GONÇALVES MATHEUS DE MORAES CUNHA , MEDEIROS ARTUR MENDES , LOPES ÂNGELA CELIS DE ALMEIDA , GOMES REGINA LUCIA FERREIRA
Published: January 2020

ABSTRACT Fava bean (Phaseolus lunatus L.) has great potential for the supply of vegetable protein, but its cultivation is still of little relevance when compared to common bean (Phaseolus vulgaris L.), being, in most cases, intercropped with other crops. The preservation of its genetic variability in germplasm banks, as well as the study of its genetic dissimilarity, has been helping in strategic design for improvement of the crop. The objective of this work was to characterize the genetic variability of morphoagronomic characters and to quantify the genetic dissimilarity among Fava bean accessions by multivariate analysis. Eight accessions from the Active Fava Bean Germplasm Bank of the Federal University of Piauí were evaluated through a randomized complete block design, with four replications, based on the number of days to maturation (NDM), mean pod length (CV), mean pod width (LV), mean pod thickness (EV), number of seeds per pod (NSV), weight of one hundred seeds (P100S) and productivity (PROD). Among the traits evaluated, only CV showed no genetic variability among the accessions. The analysis of divergence showed accessions UFPI 799 and UFPI 817 as the most divergent in relation to the others. The grouping method of Tocher and UPGMA allowed the formation of three groups. Singh's method indicated that LV, PROD and P100S contributed the most to the genetic divergence between the evaluated accessions. The accessions UFPI 817 and UFPI 797 can be used in crossings, as they are genetically distant and complementary in their characteristics.
Aplicabilidade do instrumento “Screening of Activity Limitation and Safety Awareness” em idosos com hanseníase
Authors: Nogueira Paula Sacha Frota , Barbosa Rachel Gabriel Bastos , Almeida Paulo César de , Florêncio Caroline Mary Gurgel Dias , Marques Marília Braga , Teles Liana Mara Rocha
Published: January 2020

RESUMO Objetivo Analisar a aplicabilidade da Screening of Activity Limitation and Safety Awareness (SALSA) para a avaliação da capacidade funcional de idosos com hanseníase. Método Pesquisa descritiva, transversal, desenvolvida com 77 idosos com hanseníase acompanhados no Centro de Referência em Dermatologia, em Fortaleza, Ceará, de junho a agosto de 2015, por meio da aplicação da SALSA e de outras duas escalas já validadas para uso em idosos. Para a análise, utilizou-se estatística descritiva e inferencial. Resultados Houve convergência entre as escalas (p=0,0000) na avaliação da capacidade funcional. As variáveis idade e sexo apresentaram maior número de associações com as atividades avaliadas, ao passo que, nas variáveis clínicas relacionadas à hanseníase, apenas o grau de incapacidade física apresentou relação com mais de duas atividades. Conclusão A SALSA contribuiu para a avaliação eficaz da capacidade funcional na população estudada, sendo mais influenciada pela idade do que pela hanseníase. Implicações para a prática: Assim, recomenda-se a sua aplicação nas consultas iniciais como instrumento de rastreio da capacidade funcional de idosos com hanseníase.
Do ponto de vista das moças: a circulação de afetos na Festa da Moça Nova dos Ticuna
Authors: Matarezio Filho Edson Tosta
Published: January 2020

Resumo Este artigo tem como foco a relação das moças que passam pela Festa da Moça Nova, o ritual de iniciação feminina dos índios Ticuna, com os chamados ‘bichos’ (ngo’o). Em especial, é descrito e analisado o que sentem as moças em relação a alguns ‘bichos’ que aparecem na Festa, na figura de mascarados. Alguns afetos ou emoções destacam-se na análise, como ‘medo’ (mu’ũ), ‘alegria’ ou ‘diversão’ (tchitãẽ, taẽ’ũ), ‘angústia’ ou ‘ansiedade’ (ĩãtchiãẽ), ‘desamparo’ (nhemagü’ü˜), entre outros. Por fim, há um exame do que acontece no ritual como uma espécie de ‘trauma’ que gera as transformações desejadas nos participantes da Festa.
Misfitness: the hermeneutics of failure and the poetics of the clown - Heidegger and clowns
Authors: Beré Marcelo
Published: January 2020

Abstract: The article presents some Heideggerian ideas applied to the art of clowning. Four principles of practice of the clown’s art are analysed in the light of misfitness - a concept based on the clown’s ability not to fit into theatrical, cinematic and social conventions, thus creating a language of his own. In an ontological approach, this article seeks to examine what it means to be a clown-in-the-world. Following a Heideggerian principle, the clown is analysed here taking into account his artistic praxis; a clown is what a clown does: this is the basic principle of clown poetics. The conclusion proposes a look at the clown’s way of thinking - which is here called misfit logic - and shows the hermeneutics of failure, where the logic of success becomes questionable.
Poemóbiles: o livro além do livro
Authors: Mattar Marina Ribeiro
Published: January 2020

Resumo Tomando por base a ideia de expansão do livro, este artigo propõe uma análise crítica do livro-objeto Poemóbiles, de Augusto de Campos e Julio Plaza, investigando a estrutura presente em sua poesia e materialidade, a partir dos movimentos de vanguarda do início do século XX e sua extensão ao contemporâneo. Objetivou-se colocar em perspectiva como se dá a materialidade do livro, a partir do estudo de seus aspectos estruturais e históricos e da obra de Campos, com a análise do poema Luxo, nas versões de 1965 e 1974 e com transcrições de poemas do livro para outros suportes. Compreendeu-se que Poemóbiles é um livro que extrapola a ideia de livro, em razão de sua tridimensionalidade e de sua estrutura comunicante, sendo o ponto de partida para criações em mídias menos usuais para a poesia, como o cartaz, a holografia e a escultura.
A reconstrução d’O cortiço: estratégias de adaptação do romance de Aluísio Azevedo para um jogo de tabuleiro
Authors: Thimoteo Saulo Gomes
Published: January 2020

Resumo Muitas são as formas de interação com as narrativas literárias: livros, filmes, histórias em quadrinhos, jogos etc. Com o século XXI, os métodos de adaptação ganharam força, realizando-se diversas ações de transformar histórias de um gênero em outro, criando uma série de referências que se vão cruzando e se ampliando. Nesse sentido, os jogos de tabuleiro também permitem um diálogo intertextual, recriando e evocando textos clássicos a partir de uma outra perspectiva de interação. Isso é o que se realiza no projeto de extensão “Adamastor: Laboratório de Criação de Jogos Literários”, com caráter didático, para estimular a leitura literária e ampliar sua fruição para além de um mero jogo de perguntas e respostas de compreensão e interpretação. A título de exemplo, apresenta-se o processo de adaptação para um jogo de tabuleiro do romance naturalista O cortiço, de Aluísio Azevedo, a partir dos conceitos teóricos de adaptação elaborados por Linda Hutcheon.
Por uma poética cartesiana: gráficos 3D nas criações digitais de André Vallias
Authors: Pereira Vinícius Carvalho
Published: January 2020

Resumo O laureado artista visual e poeta André Vallias, internacionalmente conhecido por suas criações na esfera da literatura eletrônica e das artes digitais, frequentemente lança mão das potencialidades do ciberespaço para a constituição multissemiótica de suas obras. Além de elementos mais comuns no campo dos diálogos interartes, tais como imagens, cores, volumes, movimento e sons, Vallias costuma empregar em suas criações um tipo de signo insólito em obras artísticas: gráficos matemáticos 3D. Trata-se de representações visuais tridimensionais (mas expressas em superfícies bidimensionais, como telas de computador e celular) de funções algébricas construídas com o software AutoCad - geralmente utilizado em projetos de áreas como a Engenharia e a Arquitetura -, às quais Vallias agrega valor artístico por meio da combinação com elementos mais tradicionais do gênero lírico, como a versificação e o ritmo. Em suas obras, tais gráficos desencadeiam um ou mais efeitos estéticos, como a representação icônica de formas geométricas do mundo referencial, a desconstrução de redutoras antinomias como subjetividade/objetividade (e, por conseguinte, pensamento poético/pensamento matemático), ou a alusão simbólica a elementos intangíveis de textos líricos, sobretudo fenômenos dos estratos fonológico e visual. Nesse contexto, o presente artigo analisa três obras de André Vallias - Nous n’avons pas compris Descartes (1997), De verso (s.d.) e Oratorio (2004) - a fim de mapear o rendimento estético do uso de gráficos matemáticos 3D como recursos artísticos que desnaturalizam nossa percepção acerca do literário e seu atravessamento por sistemas semióticos inusitados.
Slam Resistência: poesia, cidadania e insurgência
Authors: Freitas Daniela Silva de
Published: January 2020

Resumo Este artigo investiga os entrelaçamentos entre poesia, cidadania e insurgência na São Paulo contemporânea a partir do Slam Resistência, uma batalha de poesia que acontece desde 2014, todos os meses, na Praça Roosevelt, no centro da cidade. Para tanto, dada a novidade que essa nova forma de poesia constitui, apresentaremos as origens e os percursos da slam poetry até sua chegada a São Paulo e discutiremos a forma como o slam transforma a relação entre público, poeta e poesia, redefinindo seus termos. Em seguida, veremos como, ao se afiliar simultaneamente aos suportes oral, visual e escrito, o slam mistura as esferas do público e do privado, do político e do pessoal. Dessa forma, no Slam Resistência, a prática da cidadania insurgente acontece no centro da pólis e toma a praça, ocupando e ressignificando o espaço público.
Dar forma ao impublicável: Carolina Maria de Jesus e sua arte
Authors: Bergamini Atilio
Published: January 2020

Resumo Este artigo apresenta procedimentos estéticos que Carolina Maria de Jesus usou para tornar publicáveis, em Quarto de despejo, materiais que ela considerava impublicáveis. Tais procedimentos permitem conhecer alguns dos traços de um projeto estético e intelectual que parece ter orientado a escrita e a leitura de Carolina desde meados dos anos 1950 até sua morte em 1977.