bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating the relationship between the concepts of spiritual intelligence and entrepreneurship: A systematic review
Authors: Valadkhani Sara , Shariatpanahi Shabnam , Atashzadeh-Shoorideh Foroozan , Tehrani Fereshte Javaheri
Published: February 2023

Background: Entrepreneurship is a skill to start a business and an activity usually associated with new opportunities and ideas. The success of entrepreneurs depends on sharing skills and knowledge of the appropriate use of available resources. Spiritual intelligence is a term that is described as a person's capacity and ability of competence, knowledge, and skill to face his personality, to have meaning, worthwhile goals, and desire for life. The purpose of this study is to systematically review the literature that examines the relationship between the concept of spiritual intelligence and entrepreneurship .
Methods: The current study is a systematic review of the English literature within the last 10 years. We began the main process using the PRISMA 2020 guideline. To evaluate the quality of each article, we used MMAT.
Results: In the study, there were 9 studies included which all were evaluated by the MMAT, and the appraisal qualities were found to be High. The results of the current systematic review are divided into two sections; the first section comprises the predictors, the second embodies the outcomes and the third section represents the instruments.
Conclusion: In the current review of literature, after examining the most coherent literature in the area, it is found that the effects of spiritual intelligence on entrepreneurship may be influenced by many factors (environment, education, socioeconomic, experience, personality, religion). Although there is strong evidence that predicts SI to have direct effects on entrepreneurship, the research gap still needs attention in future studies.
A model based on MEREC-CRADIS objective decision-making methods and the application of double normalization: A case study of the selection of electric cars
Authors: Puška Adis , Božanić Darko , Mastilo Zoran , Pamučar Dragan
Published: February 2023

Climate changes and the number of people in the world are increasingly affecting the environment. In order to reduce this impact, there are more and more alternatives to cars with internal combustion. Currently, the most used alternative is electric cars. This research aimed to rank electric cars according to their characteristics. It was selected 13 criteria according to which 20 alternatives were ranked. For this purpose, it was used two methods, MEREC (Method based on the Removal Effects of Criteria) used to determine criterion weights objectively and CRADIS (Compromise Ranking of Alternatives from Distance to Ideal Solution) method used to rank alternatives. These methods were modified so that double normalization was used. Unlike similar approaches, the same normalization has been used here, but in two ways, which represents an innovative approach in multi-criteria decision-making (MCDM). The results of this approach have shown that the best-ranked alternative is A6 (Sono Sion), while the worst-ranked alternative is A2 (Smart EQ forfour). These results were confirmed with a comparative analysis of the results obtained using other MCDM methods and sensitivity analysis. The conducted research has shown that the application of double normalization contributes to stability in decision-making. In addition, this decision-making provides support to potential buyers for choosing electric cars.
Synthesis and characterization of the diastereomers of HHC and H4CBD
Authors: Collins Arianna C. , Ramirez Giovanni A. , Tesfatsion Tesfay T. , Ray Kyle P. , Caudill Scott , Cruces Westley
Published: February 2023

The characterization of any compound is important in the field of chemistry. As the field of cannabinoid chemistry grows so does the need for the characterization of new cannabinoids or rare cannabinoids that gain popularity within the consumer and research fields. Hexahydrocannabinol (HHC) a hydrogenated analogue of ∆9-THC, also found in trace amounts naturally within the cannabis sativa plant, has been gaining attention and popularity within the cannabis industry. Hexahydrocannabidiol (H4CBD) is a synthetic hydrogenated analogue to Cannabidiol (CBD). Identifying the Diastereomers of the cannabinoids with instrumentation plays a huge role within the chemistry field adding valuable information of the structure and the parameters for others to identify such cannabinoids. Elucidation and characterization of HHC and H4CBD was performed using current analytical techniques such as 1D and 2D NMR, HPLC, and GC-MS, effectively characterizing both the Diastereomers of HHC and H4CBD.
Effect of a 1-year tailored exercise program according to cancer trajectories in patients with breast cancer: Study protocol for a randomized controlled trial
Authors: Ryu Jiin , Lee Eun-Young , Min Jihee , Yeon Sujin , Lee Ji-Won , Chu Sang Hui , Lee Hyangkyu , Kim Seung Il , Kim Jee Ye , Park Seho , Jeon Justin Y
Published: February 2023

Background

Patients with breast cancer undergo various treatments according to their tumor subtype and cancer stages within 1 year after being diagnosed. Each treatment may cause treatment-related symptoms that have negative impacts on patients’ health and quality of life (QoL) The symptoms can be mitigated when exercise interventions are appropriately applied to patients’ physical and mental conditions. Although many exercise programs were developed and implemented during this period, the effects of tailored exercise programs according to symptoms and cancer trajectories on patients’ long-term health outcomes have not yet been fully elucidated. Therefore, this randomized controlled trial (RCT) aims to investigate the effect of tailored home-based exercise programs on short-term and long-term physiological outcomes in patients with breast cancer.

Methods

This 12-month RCT includes 96 patients with (stages 1–3) breast cancer randomly assigned to the exercise or control groups. Participants in the exercise group will receive an exercise program tailored to their phase of treatment, type of surgery, and physical function. During post-operative recovery, exercise interventions will be emphasized to improve shoulder range of motion (ROM) and strength. During chemoradiation therapy, exercise intervention will focus on improving physical function and preventing loss of muscle mass. Once chemoradiation therapy is completed, exercise intervention will focus on improving cardiopulmonary fitness and insulin resistance. All interventions will be home-based exercise programs supplemented with once-monthly exercise education and counseling sessions. The main outcome of the study is fasting insulin level at baseline, 6 months, and 1 year post-intervention. Our secondary outcomes include shoulder ROM and strength at 1 month and 3 months, body composition, inflammatory markers, microbiome, QoL, and physical activity levels at 1 month, 6 months, and 1 year post-intervention.

Conclusions

This trial is the first tailored home-based exercise oncology trial to better understand the comprehensive phase-dependent short- and long-term effects of exercise on shoulder function, body composition, fasting insulin, biomarkers, and microbiome. The results of this study will inform the development of effective exercise programs tailored to the needs of patients with breast cancer post-operatively.
Trial registration
The protocol for this study is registered with the Korean Clinical Trials Registry (KCT0007853)
Impact of some heavy metal pollution on idiopathic recurrent spontaneous abortion
Authors: El-Sikaily Amany , Helal Mohamed , Nsonwu-Anyanwu Augusta Chinyere , Azab Hossam , ElMoneim Neveen Abd , Mohammed Jihan Hassan , Hassanein Tamer , Abdel Aziza
Published: February 2023

Background
Environmental pollution with heavy metal (HM) may be associated with human reproductive failure where pollutants are accumulated in marine organisms and sediment and subsequently transferred to man through food chain. Oxidative stress and disruption of homeostatic regulation of reproductive hormones has been implicated in HM induced reproductive toxicity. The HM, indices of oxidative stress, reproductive hormone and red cell indices in women with recurrent pregnancy loss (RPL) were assessed in this study.
Methods
Seventy-six women (20–35 years) categorized into 18 fertile women without RPL (control group), and Groups I, II and III comprising 24, 18 and 16 women with RPL (2, 3, and > 3 abortions respectively) were studied. Whole blood samples were collected for the estimation of cadmium (Cd), lead (Pb), metallothionein (rbcMT), malondialdehyde (MDA), reduced glutathione (GSH), progesterone, haemoglobin (Hb), mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH). Mussel samples were collected for Cd, Pb and metallothionein (MT) estimation.
Results
The cadmium content of mussels were above the maximum limit. Women with RPL (Groups I-III) had higher Cd, Pb, rbcMT and MDA and lower catalase, GSH, P4, Hb, MCV and MCH compared to Group I (p = < 0.001). Negative associations were observed between Cd and catalase (r=-0.320, p = 0.014), GSH (r=-0.359, p=-0.006) and MCV (r=-0.391, p=-0.002) respectively and between Pb and GSH (r=-0.501, p = < 0.001), Hb (r=-0.289, p = 0.028), MCV (r=-0.394, p = 0.002) and MCH (r=-0.277, p = 0.036) respectively in women with RPL. Positive correlations were observed between Cd and Pb (r = 0.533, p = < 0.001), rbcMT with Cd (r = 0.312, p = 0.017), Pb (r = 0.488, p = < 0.000) and MDA (r = 0.282, p = 0.032) respectively in women with RPL.
Conclusion
Elevated cadmium levels in mussels, metallothionein, MDA and reduced antioxidants, progesterone and red cell indices observed in women with RPL suggest that HM induced oxidative stress and hormonal imbalance may be implicated in recurrent pregnancy loss.
Improving the accuracy of blood pressure measuring devices in Australia: a modelled return on investment study
Authors: Desson Zachary , Sharman James , Searles Andrew , Schutte Aletta , Delles Christian , Olsen Michael , Ordunez Pedro , Hure Alexis , Morton Rachael , Figtree Emma , Webster Jacqui , Jennings Garry , Redfern Julie , Nicolls Stephen , McNamara Martin , Deeming Simon , Doyle Kerry , Ramanathan Shanthi
Published: February 2023

Introduction:

The VALID BP project was initiated to increase the availability of validated blood pressure measuring devices (BPMDs). The goal is to eliminate non validated BPMDs and minimise over- and underdiagnosis of hypertension caused by inaccurate readings. This study was undertaken to assess the potential return on investment in the VALID BP project.

Methods:

The Framework to Assess the Impact of Translational health research was applied to the VALID BP project. One of the three methods used included a cost benefit analysis to monetise past research investment and model future research costs, implementation costs and benefits. Analysis was based on reasoned assumptions about potential impacts from availability and use of validated BPMDs (assuming an end goal of 100% validated BPMDs available in Australia by 2028) and improved skills leading to more accurate BP measurement.

Results:

After five years, with 20% attribution of benefits, there is a potential $1.29 return for every dollar spent if the proportion of validated BPMDs and staff trained in proper BP measurement technique increased from 20–60%. After eight years (2020–2028) and assuming universal validation and training coverage, the returns would be $3.20 per dollar spent (not including cost of side-effects of unnecessary medication or downstream patient impacts from unmanaged hypertension).

Conclusion:

This modelled economic analysis indicates there will be positive downstream economic benefits if the availability of validated BPMDs is increased. The findings support ongoing efforts toward a universal regulatory framework for BPMDs and can be considered within more detailed future economic analyses.
PET117 Modulates Mitochondrial-encoded COX1 Translation by stabilizing TACO1
Authors: Sun Qiong , Shi Le , Li Shuaijun , Feng Yan , Wang Shuxia , Li Jialu , Li Xinyue , Zhang Ruifen , Huang Xinghuai , Shao Yongping , Feng Zhihui , Peng Yunhua , Yang Zhiwei , Liu Jiankang , Liu Huadong , Long Jiangang
Published: February 2023

Mitochondria are the most important organelles in energy metabolism. Complexes of the mitochondrial oxidative phosphorylation system (OXPHOS) are formed by proteins of dual origin synthesized in the cytosol or mitochondria. The mechanisms underlying specific translation by mitoribosomes in mammals are largely unknown. Here, we report a chaperone protein of cytochrome c oxidase (COX) assembly, PET117 plays a critical role in the synthesis of mitochondrial-encoded COX1 protein in human cells. Lack of PET117 impaired mitochondrial function via suppression of mitochondrial oxygen consumption rate (OCR), probably due to reduced stability of TACO1, a COX1 translational activator. We uncovered the role of PET117 in mitochondrial regulation and a novel PET117-TACO1 axis modulating mitochondrial gene expression.
New drugs and stock market: how to predict pharma market reaction to clinical trial announcements
Authors: Budennyy Semen , Kazakov Alexey , Kovtun Elizaveta , Zhukov Leonid
Published: February 2023

Pharmaceutical companies operate in a strictly regulated and highly risky environment in which a single slip can lead to serious financial implications. Accordingly, the announcements of clinical trial results tend to determine the future course of events, hence being closely monitored by the public. In this work, we provide statistical evidence for the result promulgation influence on the public pharma market value. Whereas most works focus on retrospective impact analysis, the present research aims to predict the numerical values of announcement-induced changes in stock prices. For this purpose, we develop a pipeline that includes a BERT-based model for extracting sentiment polarity of announcements, a Temporal Fusion Transformer for forecasting the expected return, a graph convolution network for capturing event relationships, and gradient boosting for predicting the price change. The challenge of the problem lies in inherently different patterns of responses to positive and negative announcements, reflected in a stronger and more pronounced reaction to the negative news. Moreover, such phenomenon as the drop in stocks after the positive announcements affirms the counterintuitiveness of the price behavior. Importantly, we discover two crucial factors that should be considered while working within a predictive framework. The first factor is the drug portfolio size of the company, indicating the greater susceptibility to an announcement in the case of small drug diversification. The second one is the network effect of the events related to the same company or nosology. All findings and insights are gained on the basis of one of the biggest FDA (the Food and Drug Administration) announcement datasets, consisting of 5436 clinical trial announcements from 681 companies over the last five years.
APOBEC3B coordinates R-loop to promote replication stress and sensitize cancer cells to ATR/Chk1 inhibitors
Authors: Zong Chunyan , Zhang Zhe , Gao Li , He Jie , Wang Yiran , Li Qian , Liu Xiaoting , Yang Jie , Chen Di , Huang Rui , Zheng Guopei , Jin Xiaoliang , Wei Wu , Jia Renbing , Shen Jianfeng
Published: February 2023

The cytidine deaminase, Apolipoprotein B mRNA editing enzyme catalytic subunit 3B (APOBEC3B, herein termed A3B), is a critical mutation driver that induces genomic instability in cancer by catalyzing cytosine-to-thymine (C-to-T) conversion and promoting replication stress. However, the detailed function of A3B in replication stress is not fully determined and it is not known whether the mechanism of A3B action can be exploited for cancer therapy. Here, we conducted an immunoprecipitation-mass spectrometry (IP-MS) study and identified A3B to be a novel binding component of R-loops, which are RNA:DNA hybrid structures. Mechanistically, overexpression of A3B exacerbated replication stress by promoting R-loop formation and altering the distribution of R-loops in the genome. This was rescued by the R-loop gatekeeper, Ribonuclease H1 (RNASEH1). In addition, a high level of A3B conferred sensitivity to ATR/Chk1 inhibitors in melanoma cells, which was dependent on R-loop status. Together, our results provide novel insights into the mechanistic link between A3B and R-loops in the promotion of replication stress in cancer. This will inform the development of markers to predict the response of patients to ATR/Chk1 inhibitors.
Magnetic proximity-induced energy gap of topological surface states
Authors: Wang Jiashu , Wang Tianyi , Ozerov Mykhaylo , Zhang Zhan , Ortiz Joaquin Bermejo , Bac Seul-Ki , Trinh Hoai , Zhukovskyi Maksym , Orlova Tatyana , Ambaye Haile , de Vaulchier Louis-Anne , Keum Jong Kahk , Guldner Yves , Lauter Valeria , Smirnov Dmitry , Liu Xinyu , Assaf Badih
Published: February 2023

Topological crystalline insulator surface states can acquire an energy gap when time reversal symmetry is broken by interfacing with a magnetic insulator. Such hybrid topological-magnetic insulator structures can be used to generate novel anomalous Hall effects and to control the magnetic state of the insulator in a spintronic device. In this work, we successfully observe the energy gap of topological surface states in proximity with a magnetic insulator using magnetooptical Landau level spectroscopy. The measurements are carried out on Pb1-xSnxSe – EuSe heterostructures grown by molecular beam epitaxy exhibiting record mobility and a low Fermi energy. Through temperature dependent measurements combined with theoretical calculations, we show that the origin of this gap is likely related to quantum confinement, which allows us to conclude that the magnetic proximity effect is weak in this system. The recovered energy gap sets an upper limit for the Fermi level needed to observe the quantized anomalous Hall effect using magnetic proximity heterostructure
Signal Propagation in Resettable Mechanical Logic
Authors: Panas Robert , Sun Frederick , Farzaneh Amin , Cortes John , Bekker Logan , Johnson Hilary , Mancini Julie , Pascall Andrew , Hopkins Jonathan
Published: February 2023

Unconventional computing, such as mechanical1 and microfluidic logic circuits2, quantum gates3, and mechanical metamaterials4 create opportunities for embedded computation, which overcome the power5, package size, and environmental limitations of conventional electronics. Emerging micro-manufacturing capabilities6 with environmentally robust materials enable mechanical logic circuits miniaturization. Kinematically, bistable logic propagates binary signals through cascading gate displacement transitions. Energetically, the inter- and intra- node compliances are tuned for re-programmable signal propagation. Applications need computational architectures which integrate resettable signal propagation7–10, logical operation11–16, and signal storage17–19. While many researchers explore aspects of these elements1, 20–23, none consider energetic limits and propagation dynamics to evaluate and advance the field. Here, we show a generalized model and metrics, validated by experimental results, that enables the design of scale-independent, resettable, mechanical logic circuits. By studying propagation energy flows, we identified non-dimensional operating regimes in which signals propagate and resettable logic is possible. We provide deterministic design methods to evaluate future divergent topologies for displacement-based mechanical logic structures. Our results demonstrate the framework for designing densely integrated mechanical computation systems which harvest available ambient energy to propagate computational cascades. This logic responds to multi-dimensional environmental inputs and thus enables re-programmable, powerless, and embedded computation.
Cuproptosis related gene PDHB was identified as a biomarker and its up-regulation inhibited the invasion of renal clear cell carcinoma
Authors: Wang Hu , Yang Zhan , He Xingyu , Guo Fengran , Sun Hao , Xu Sen , Xu Chao , Wang Zhu , Wen Hongzhuang , Teng Zhihai , Wang Yaxuan , Han Zhenwei
Published: February 2023

Background
Cuproptosis is a newly discovered programmed cell death dependent on mitochondrial respiratory disorder induced by copper overload. PDHB is one of the genes responsible for cuproptosis and is a nuclear encoded pyruvate dehydrogenase, an enzyme that catalyzes the conversion of pyruvate to acetyl coenzyme A. However, the mechanism of PDHB in renal clear cell carcinoma remains unclear.
Methods
We used data from TCGA and GEO to assess the expression of PDHB in normal and tumor tissues. We analysed the relationship between PDHB and somatic mutations and immune infiltration. Finally, we explored the impact of overexpressed PDHB on renal clear cell carcinoma.
Results
PDHB is lowly expressed in tumor tissue and reduced in high-grade tumors. Highly expressed PDHB has a better prognosis in ccRCC. In ccRCC, low PDHB expression may be associated with higher VHL, PBRM1 and KDM5C mutations. Addition of copper chloride to the 786-O cell line resulted in inhibition of cell growth and increased expression of the cuproptosis genes DLAT, PDHB and FDX1. Finally, the experiments verified that overexpression of PDHB inhibited the proliferation and migration of ccRCC cells.
Conclusion
Our results demonstrate that elevated PDHB expression inhibits the proliferation, migration and invasion of renal clear cell carcinoma cells, improves the prognosis of renal cancer patients and may provide a new therapeutic strategy for patients with advanced renal cancer.
Severe clozapine toxicity-The pharmacokinetic profile of clozapine and it’s important role in hemodynamic：case report
Authors: Yu Zhu-Xi , PI Yang , Chen Meikai , Dong Danjiang , Gu Qin
Published: February 2023

Background: Hemodynamic instability in patients with clozapine intoxication can indirectly reflect the serum concentration of clozapine.
Case presentation: We have described a case of a 32-year-old pregnant woman who developed life-threatening clozapine toxicity at 28 weeks of gestation. The levels of clozapine and norclozapine in the serum were high.We initiated hemoperfusion(HP) and other detoxification therapies to remove the drug. The patient had severely dilated peripheral blood vessels, which led to cardiac symptoms such as fatal hypotension and uncontrollable tachycardia, resulting in very high cardiac output and elevated Central venous oxygen saturation(ScvO2). Pharmacological intervention significantly improved the hemodynamics.
Conclusions: Based on our findings in the current case, we hypothesize that hemodynamic monitoring before and after blood detoxification can help assess the efficacy and guide treatment.
Transcriptomic profiles of Pectoralis major muscles affected by spaghetti meat and woody breast in broiler chickens
Authors: Che Sunoh , Pham Phuc , Barbut Shai , Bienzle Dorothee , Susta Leonardo
Published: February 2023

Spaghetti meat (SM) and woody breast (WB) are breast muscle myopathies of broiler chickens, characterized by separation of myofibers and by fibrosis, respectively. This study sought to investigate the transcriptomic profiles of breast muscles affected by SM and WB. Targeted sampling was conducted on a flock to obtain 10 WB, 10 SM, and 10 Normal Pectoralis major muscle samples. Total RNA was extracted, cDNA was used for pair-end sequencing, and differentially expressed genes (DEGs) were determined by a false discovery rate of < 0.1 and a > 1.5-fold change. Principal component and heatmap cluster analyses showed that SM and WB samples clustered together. No DEGs were observed between SM and WB fillets, while a total of 4,018 and 2,323 DEGs were found when comparing SM and WB, respectively, against Normal samples. In both SM and WB samples, Gene Ontology terms associated with extracellular environment and immune response were enriched. The KEGG analysis showed enrichment of cytokine–cytokine receptor interaction and extracellular matrix–receptor interaction pathways in both myopathies. Although SM and WB are macroscopically different, the similar transcriptomic profiles suggest that these conditions may share a common pathogenesis. The similarity between the two conditions may be used to find mitigation measures.
A cluster randomized controlled trial of small quantity lipid based supplements versus unconditional cash transfer in the prevention of chronic malnutrition in Southern Angola: study protocol for the MuCCUA study.
Authors: Custodio E , Herrador Z , Trigo E , Romay-Barja M , Ramirez F , Aguado I , Iraizoz E , Silva-Gerardo A , ML Faria , Martin-Cañavate R , Marques T , Vargas A , Gómez A , Molina I
Published: February 2023

Background: Chronic malnutrition is a condition that can have important negative impacts on subsequent physical and cognitive development. It is multi-causal and can start very early in life, already in utero, thus it is especially challenging to find appropriate interventions to tackle it. The supplementation with small quantity lipid based nutrients (SQ-LNS) and the provision of cash transfers are promising interventions to prevent it but more operational research is needed to gain evidence on their effectiveness.
Methods/Design: The Crescer project aims to evaluate the impact of a SQ-LNS intervention and a cash transfer intervention in the lineal growth of children less than 2 years old in Southern Angola. The three-arm parallel cluster randomised controlled trial is set in four comunas of Huila and Cunene provinces. Pregnant women are recruited, and treatment arms receive unconditional cash or SQ-LNS plus a food family ration for the first 1000 days, from pregnancy through the child reaching 24 months. A comparison group receives “standard of care” provided by the Crescer project to which all groups have the same access. The primary outcome is the prevalence of stunting measured as height-for-age Z-score (HAZ) < -2 in children below 2 years. Impact will be assessed at 3, 6, 12, 18 and 24 months of children’s age. Secondary outcomes include mortality, morbidity, caring, hygiene and nutrition behaviours and practices, and women and children’s dietary diversity. Quantitative data are also collected on women’s empowerment, household food security, expenditure and relevant clinical and social events at base line, end line and intermediate time points.
Discussion: The results of this trial will provide valuable information on the impact of a SQ LNS and an unconditional cash transfer intervention, carried out during the first 1000 days, in the children´s growth up to 2 years, and related outcomes.
Trial registration: Clinical Trials NCT05571280. Registered 7 October 2022.
Reporting quality of randomized controlled trials of angina pectoris with integrated traditional Chinese and western medicine interventions: a cross-sectional study
Authors: Deng Jiashuai , He Juan , Wang Juan , Cheng Chung Wah , Jiao Yalin , Wang Nana , Li Ji , Wang Ping , Han Fei , Lyu Aiping , Bian Zhaoxiang , Zhang Xuan
Published: February 2023

Background and objective: Integrated traditional Chinese and western medicine (ITCWM), as a representative type of complex intervention, is commonly used for the treatment of angina pectoris (AP) in clinical practice. However, it is unclear whether the details of ITCWM interventions, such as selection rationale, implementation, study design and potential interactions, were adequately reported. Therefore, this study aimed to assess the quality of reporting in the ITCWM interventional randomized controlled trials (RCTs).
Methods: Through a search of 7 international electronic databases, we identified RCTs of AP with ITCWM interventions published in both English and Chinese from 1st Jan 2017 to 6th Aug 2022. The general characteristics of included studies were summarized, further, the quality of reporting was assessed based on three Checklists, including the CONSORT (Consolidated Standards of Reporting Trials) with 36 items (except for one item 1b about abstract), the CONSORT for abstracts (17 items), and a self-designed ITCWM-related checklist (21 items covering design rationale, intervention details, outcome assessment and analysis). The quality of RCTs published in English journals, Chinese journals and dissertations were also compared.
Results: A total of 451 eligible RCTs were included. For the reporting compliance, the mean score (standard deviation) of the CONSORT (72 score in total), CONSORT for abstract (34 score in total), and ITCWM-related (42 score in total) checklists was 35.67 (4.02), 13.17 (2.14), and 20.93 (3.95), respectively. More than 50% items were evaluated as poor quality (reporting rate＜50%) among each Checklist. Moreover, the reporting quality of publications in English journals was significantly higher than that in Chinese journals regarding the CONSORT compliance (p<0.05), but there were no differences among journals regarding the CONSORT for Abstract and ITCWM-related reporting (p>0.05). The reporting of dissertations was better than journal publications in comparison of the CONSORT and ITCWM-related items (p<0.05).
Conclusion: Although CONSORT appears to have enhanced the reporting of RCTs in AP, the quality of ITCWM specifics is variable and in need of improvement. Reporting guideline of the ITCWM recommendations should be developed thus to improve their quality.
A systematic review and net meta-analysis of the effects of different warm-up methods on the acute effects of lower limb explosive strength
Authors: LI Fuyou , GUO Chenggen , LI Huashuai , XU Haoran , SUN Pu
Published: February 2023

Objective: To evaluate the effects of different warm-up methods on the acute effect of lower limb explosive strength with the help of a reticulated meta-analysis system and to track the optimal method.
Methods: R software combined with Stata software, version 13.0, was used to analyse the outcome metrics of the 35 included papers.
Results: 1) Static combined with dynamic stretching [MD = 1.80, 95% CI: (0.43, 3.20)] and dynamic stretching [MD = 1.60, 95% CI: (0.67, 2.60)] were significantly better than controls in terms of improving reverse long jump performance, and the effect of dynamic stretching was influenced by the duration of stretching (I2 = 80.4%), study population (I2 = 77.2%) and age (I2 = 75.6%) as moderating variables, with the most significant effect size for dynamic stretching time of 7-10 min. 2) Only dynamic stretching [MD = -0.08, 95% CI: (-0.15, -0.008)] was significantly better than the control group in terms of improving sprint performance, while static stretching [MD = 0.07, 95% CI: (0.002, 0.13)] showed a significant, negative effect. 3) No results were available to demonstrate a significant difference between other methods, such as foam axis rolling, and the control group.
Conclusion: Static stretching was able to reduce explosive performance, while the 2 warm-up methods, namely dynamic stretching and static combined with dynamic stretching, were able to significantly improve explosive performance, with dynamic stretching being the most stable and moderated by multiple variables and dynamic stretching for 7-10 min producing the best explosive performance. In the future, high-quality studies should be added based on strict adherence to test specifications.
Association between Antenatal Care Facility Readiness and Provision of Care at the Individual and Facility Level in Five Low- and Middle-Income Countries
Authors: Sheffel Ashley , Carter Emily , Zeger Scott , Munos Melinda K.
Published: February 2023

Background
Despite growing interest in monitoring improvements in quality of care, data on service quality in low-income and middle-income countries (LMICs) is limited. While health systems researchers have hypothesized the relationship between facility readiness and provision of care, there have been few attempts to quantify this relationship in LMICs. This study assesses the association between facility readiness and provision of care for antenatal care at the client level and facility level.
Methods
To assess the association between provision of care and various facility readiness indices for antenatal care, we used multilevel, multivariable random-effects linear regression models. We tested an inflection point on readiness scores by fitting linear spline models. To compare the coefficients between models, we used a bootstrapping approach and calculated the mean difference between all pairwise comparisons. Analyses were conducted at client and facility levels.
Results
Our results showed a small, but significant association between facility readiness and provision of care across countries and most index constructions. The association was most evident in the client-level analyses that had a larger sample size and were adjusted for factors at the facility, health worker, and individual levels. In addition, spline models at a facility readiness score of 50 better fit the data, indicating a plausible threshold effect.
Conclusions
The results of this study suggest that facility readiness is not a proxy for provision of care, but that there is an important association between facility readiness and provision of care. Data on facility readiness is necessary for understanding the foundations of health systems particularly in countries with the lowest levels of service quality. However, a comprehensive view of quality of care should include both facility readiness and provision of care measures.
Extracellular vesicles-derived microRNA-145-5p is upregulated in the uterine fluid of women with endometriosis and impedes mouse and human blastocyst development
Authors: Li Xiong , Fu Jing , Jiang Wanjun , Zhang Wenbi , Xu Yan , Gu Ruihuan , Qu Ronggui , Zou Yaoyu , Li Zhichao , Sun Yijuan , Sun Xiaoxi
Published: February 2023

Background
Previous work indicated that the implantation and pregnancy rates of women with endometriosis are lower than those of healthy women during in-vitro fertilisation and embryonic transfer. And there are numerous miRNAs in human uterine luminal fluid (ULF), some of which are associated with early preimplantation development of embryos. In our study, we sought to determine whether microRNAs (miRNAs) in the ULF are differentially expressed between women with and without endometriosis and to uncover the association of miRNAs with the development potential of blastocysts.
Methods
In this case-controlled study, 30 ULF samples were collected each from women with and without endometriosis between March 2018 and May 2019, respectively. TaqMan human miRNA cards and quantitative reverse transcription polymerase chain reaction were used to identify differentially expressed ULF microRNAs between the two groups. Furthermore, the role of miR-145-5p-enriched EVs in mouse and human early embryos was investigated by co-incubation with or without corresponding microRNA-mimic oligonucleotide-enriched EVs, and the effect of miR-145-5p upregulation was investigated on Notch/NOTCH signalling genes.
Results
The implantation and clinical pregnancy rates significantly decreased in women with endometriosis than in those without endometriosis. Notably, hsa-miR-145-5p was upregulated in ULF samples from women with endometriosis (fold change > 2, false discovery rate < 0.001). Moreover, the ratios of mouse/human early embryos that developed into blastocyst-staged embryos (P = 0.0037 and P = 0.0079, respectively) were significantly affected via miR-145-5p upregulation in mouse/human early embryos. Notch signalling pathway components had abnormal expression levels in the mouse/human blastocyst-stage embryos in the miR-145-5p mimic-enriched EVs group.
Conclusions
Our study revealed that human extracellular vesicle-derived microRNAs in ULF impacted the developmental potential of blastocysts in women with endometriosis. Moreover, the upregulation of miR-145-5p-enriched EVs in mouse and human embryos negatively affected blastocyst development by suppressing the expression of components of the NOTCH signalling pathway, which may contribute to elucidate the cause of infertility in women with endometriosis.
Non-invasive super-resolution imaging through scattering media using object fluctuation
Authors: Dang Cuong , Zhu Xiangwen , Sahoo Sujit , Tobing Landobasa Y.M. , Adamo Giorgio , Zhang Dao Hua
Published: February 2023

Introducing super-resolution techniques to imaging through scattering media potentially revolutionizes the technical analysis for many exotic applications, such as cell structures behind biological tissues. The main challenge is scattering media’s inhomogeneous structures, which scramble the light path and create noise-like speckle patterns, hindering the object’s visualization even at a low-resolution level. Here, we propose a computational method relying on the object’s spatial and temporal fluctuation to visualize nanoscale objects through scattering media non-invasively. Taking advantage of the optical memory effect and multiple frames, we estimate the point spreading function (PSF) of the scattering media. Multiple images of the fluctuating object are obtained by deconvolution; then, the super-resolution image is achieved by computing the high-order cumulants. Non-linearity of high order cumulant significantly suppresses the artifacts in the resulting images and enhances the resolution by a factor of √N, where N is the cumulant order. Our proof-of-concept demonstration shows 188-nm FWHM feature at 12nd cumulant order, breaking the Rayleigh diffraction limit by a factor of 3.46. Our non-invasive super-resolution speckle fluctuation imaging (NISFFI) presents a nanoscopy technique with straightforward imaging hardware configuration to visualize samples behind scattering media.
Overview of modeling techniques for ecological Connectivity in heterogeneous landscape
Authors: Tiwari Amrapali , Saran Sameer , Avishek Kirti
Published: February 2023

Ecological connectivity in a landscape is one of the crucial factors for biodiversity conservation. Especially in case of large mammals like top carnivores. Frequent environmental changes have resulted in isolated world’s wildlife population which leads to increased pace biodiversity loss. Moreover, Increased human inhabitants and population shift towards the edge of forests provides animals with very less or no scope of living in the wilderness. As a result, ecological connectivity analysis and landscape planning are integral part of one another. This paper reviews the available techniques for quantifying dispersal in the landscape. A critical and thorough review of available theories of wide range of methods, techniques and tools for corridor analysis in conservation scenario is done in this paper. It also compiles various approach utilized globally. An exhaustive discussion on modeling techniques such as graph theoretic approaches (least cost path analysis, network analysis, etc), circuit theoretic approaches, agent based models and machine learning based approach is compiled for improved decision making.
Dynamical analysis of a forced vibrating planar motion of a spring pendulum
Authors: Amer T. S. , Amer Asmaa , Galal Abdallah Abbas
Published: February 2023

This work studies the nonlinear movement of a two degrees-of-freedom (DOF) spring pendulum that is dampened and affected by a torque and harmonic force externally. It is presumed that the spring’s pivot point travels along an elliptic route. Lagrange's equations are utilized to generate the regulating system of motion. The multiple-scales approach (MSA) is used to gain the system’s analytic solutions up to the third approximation. Therefore, all resonance cases that have emerged are categorized, wherein two of them are scrutinized at once. As a result of the removal of secular terms, the solvability constraints are attained and then the steady-state solutions are investigated. The examined motion's temporal evolution, the resonance response curves, and the solutions at the steady-state are all depicted graphically. In compliance with the Routh-Hurwitz criteria (RHC), all possible fixed points (FP) for the cases of steady and unsteady are found and displayed. The stability zones are examined and analysed to estimate the effect of various factors on the system’s behavior. This model has gained prominence recently due to its industrial uses in fields including construction, infrastructure, transportation, and vehicles.
Association of the barriers of pharmaceutical care perceived by clinical pharmacists and occupational stress in tertiary hospitals of China
Authors: Zhang Yu , Xi Xiaoyu , Huang Yuankai
Published: February 2023

Background
As an important member of the health care team, clinical pharmacists' occupational stress will lead to the decline of pharmaceutical care quality. Chinese clinical pharmacists are facing high work pressure. Person-environment fit theory indicated that the barriers of pharmaceutical care may be a potential factor associated with occupational stress. However, in clinical practice, it is unclear whether the perceived barriers of clinical pharmacists affect occupational stress in clinical practice and which barriers will affect.
Objective
This study aimed to assess the association between the specific barriers of pharmaceutical care perceived by clinical pharmacists and their occupational stress in China.
Method
A field questionnaire survey using a stratified sampling was conducted to gather data on occupational stress, barriers of pharmaceutical care perceived by clinical pharmacists, and other factors of occupational stress using the Brief Job Stress Questionnaire and a self-developed instrument. Ordinary least squares regression was used to evaluate the association of the participants’ knowledge, skills, and other factors with their occupational stress.
Results
A total of 625 clinical pharmacists from 311 tertiary hospitals in China (response rate = 84%) participated. Perceived resource dimension (p = 0.00) and self-improvement dimension barriers (p = 0.01) was associated with increased occupational stress of the participants. In addition, clinical pharmacists’ technical titles and specialized field are associated with their occupational stress.
Conclusion
By reducing some specific barriers of pharmaceutical care perceived by clinical pharmacists, the occupational stress can be relieved, so as to improve the quality and efficiency of clinical pharmaceutical care.
The Effect of Sarcopenia on Survival in Patients with Metastatic Colon Cancer
Authors: dogan ozlem , Sahinli Hayriye , zeynelgil esra , simsir begum demirler , imamoglu goksen inanc
Published: February 2023

Introduction: Sarcopenia is a common loss of muscle mass in cancer patients. Our aim in this study is to investigate the effect of sarcopenia on survival in patients with metastatic colon cancer.
Material and Methods: The study was carried out retrospectively in patients diagnosed with metastatic colon cancer between January 2016 and December 2020. Sarcopenic patients were determined by total psoas area index and Hounsfield unit average calculation using computed tomography (CT) scan images obtained at the time of diagnosis.
Results: A total of 70 patients with metastatic colon cancer were evaluated. Sarcopenia was detected in 18 patients (25.7%). The median age of sarcopenic patients was 72 (53-83) years. A significant correlation was found between age and sarcopenia (p=0.002). Median survival of sarcopenic patients was 11 months while non-sarcopenic patients had a median survival of 24 months. A difference was found in overall survival (OS) between the two groups (p=0.021). There was no difference in progression free survival (PFS) between sarcopenic and non-sarcopenic patients.
Conclusions: In our study, a significant prognostic effect of sarcopenia on survival was found in patients with metastatic colon cancer. The survival of sarcopenic patients was poorer.
Problem gambling among people with first-episode psychosis: protocol for a prospective multicenter cohort study
Authors: Corbeil Olivier , Soulard Manuel , Huot-Lavoie Maxime , Béchard Laurent , Fournier Émilien , Brodeur Sébastien , Essiambre Anne-Marie , Desmeules Charles , Thériault Chantale , Abdel-Baki Amal , Jacques Christian , Giroux Isabelle , Dorval Michel , Roy Marc-André , Demers Marie-France
Published: February 2023

Background
The limited available data suggest that the prevalence of problem gambling is increased among young adults with first-episode psychosis, possibly due in part to several risk factors for problem gambling that are common in this population. Aripiprazole, a widely used antipsychotic drug, has also been linked to cases of problem gambling, but causality remains uncertain. Although the consequences of problem gambling further hinder the recovery of people with first-episode psychosis, there is a paucity of research about this comorbidity and its risk factors. Additionally, to our knowledge, no screening instrument for problem gambling tailored to these individuals exists, contributing to its under-recognition. Further, treatment approaches for problem gambling adapted to this population are at an embryonic stage, while existing treatments effectiveness remains to be documented. Using an innovative screening and assessment procedure for problem gambling, this study aims to identify risk factors for problem gambling among people with first-episode psychosis and to document the effectiveness of standard treatment approaches.
Methods
This is a multicenter prospective cohort study conducted in two first-episode psychosis clinics, including all patients admitted between November 1st, 2019, and November 1st, 2023, followed for up to 3 years until May 1st, 2024. These 2 clinics admit approximately 200 patients annually, for an expected sample size of 800 individuals. The primary outcome is the occurrence of a DSM-5 diagnosis of gambling disorder. All patients are screened and evaluated for problem gambling using a systematic procedure at admission, and every 6 months thereafter. Socio-demographic and clinical variables are prospectively extracted from the patients’ medical records. The nature and effectiveness of treatments for problem gambling offered to affected individuals are also documented from medical records. Survival analyses with Cox regression models will be used to identify potential risk factors for problem gambling. Descriptive statistics will document the effectiveness of treatments for problem gambling in this population.
Discussion
A better understanding of potential risk factors for problem gambling among people with first-episode psychosis will allow for better prevention and detection of this neglected comorbidity. Results of this study will also hopefully raise clinicians’ and researchers’ awareness and serve as the basis to adapted treatments that will better support recovery.
Trial registration:
ClinicalTrials.gov, NCT05686772. Retrospectively registered, 9 January 2023.