bluuebunny/crossref_metadata_2025 huggingface dataset:
Análisis de genotipos, alelos y haplotipos de HLA en un grupo de pacientes con artritis psoriásica: poca frecuencia de alelos comunes
Authors: Calixto Omar-Javier , Meneses-Toro María-Alejandra , Chacón Paula Andrea , Acevedo-Godoy Mónica , Robayo Luisa Constanza , Bello-Gualtero Juan Manuel , Bautista-Molano Wilson , Noguera Verónica , Cortés Jaime , Romero-Sánchez Consuelo
Published: January 2025

Introducción. La artritis psoriásica es una enfermedad compleja y los antígenos leucocitarios humanos (Human Leukocyte Antigen, HLA) son un factor clave en el desarrollo de la enfermedad. En Latinoamérica, hay pocos datos sobre dichos antígenos en pacientes con artritis psoriásica.Objetivo. Describir la frecuencia de genotipos, alelos y haplotipos de los antígenos leucocitarios humanos en casos de artritis psoriásica y asociarlos con variables clínicas.Materiales y métodos. Se desarrolló un estudio retrospectivo del 2012 al 2023 en el que se evaluaron los adultos con artritis psoriásica según los criterios CASPAR. Se incluyeron controles sanos con HLA-A, B, C y DR tipificados por PCR/SSO en un dispositivo Luminex 100/200 xMAP™. Se hizo un análisis comparativo entre los datos de los antígenos leucocitarios de los pacientes y los de los controles sanos.Resultados. Se incluyeron 401 controles sanos y 37 pacientes con artritis psoriásica, entre los cuales se identificaron 46 genotipos, 75 alelos y 32 haplotipos. Los HLA más frecuentes fueron HLA-A*24 (37,1 %), HLA-B*35 (20,8 %), HLA-C*03 y HLA-C*07 (cada uno con el 19,9 %) y HLA-DR*04 (30 %). Al comparar su frecuencia con la de los controles sanos, la frecuencia genotípica fue menor para HLA-A*02, HLA-A*11, HLA-B*35, HLA-DR*01, HLA-DR*07, HLA-DR*13 y HLA-DR*15 (p < 0,05), lo que significa que, si bien el HLA-B*35 fue frecuente en la artritis psoriásica, su frecuencia fue menor al compararse con la de los controles. La frecuencia de HLA-A*24 y HLA-B*44 fue diferente en los pacientes con compromiso cutáneo (p < 0,05); la de HLA-B*40 y HLA-B*35 en aquellos con compromiso articular (p < 0,05), y la de HLA-A*26 y HLA-C*16 en aquellos con manifestaciones extraarticulares (p < 0,05). La frecuencia alélica de HLA-A*26:01 y HLA-C*16:01 en los casos con manifestaciones extraarticulares, fue también significativa. La frecuencia de HLA-Cw*6 fue 6,7 % y la ausencia de HLA-B*27 en nuestra población es uno de los aspectos por destacar.Conclusiones. En el análisis de HLA en artritis psoriásica se encontrótró una poca frecuencia de HLA-C*06 y ausencia de HLA-B*27. Este hallazgo es diferencial respecto a la población caucásica. Estos resultados revelaron otros alelos de interés, algunos relacionados con variables clínicas. Las diferencias encontradas podrían estar relacionadas con la mezcla racial de nuestra población.
Descripción clínica y genética de pacientes con enfermedad granulomatosa crónica en un hospital pediátrico
Authors: Berriozábal-Villarruel Xareni , Godínez-Zamora Guadalupe Fernanda , Baeza-Capetillo Patricia , Pérez-Blanco Uriel , Espinosa -Padilla Sara Elva , Aguirre-Hernández Jesús , Blancas-Galicia Lizbeth , Saucedo-Ramírez Omar Josué
Published: January 2025

Introducción. La enfermedad granulomatosa crónica es un error innato de la inmunidad caracterizado por aumento de la susceptibilidad a desarrollar infecciones por hongos y bacterias, e inflamación no regulada. Se produce por defectos en la coenzima NADPH oxidasa y la proteína EROS.Objetivo. Caracterizar clínica y genéticamente cuatro pacientes con enfermedad granulomatosa crónica del Hospital Infantil de México Federico Gómez.Material y métodos. Los pacientes con diagnóstico de enfermedad granulomatosa crónica diagnosticados por la técnica de oxidación de dihidrorrodamina, fueron caracterizados molecular y genéticamente mediante la medición de la expresión de las subunidades de la NADPH oxidasa, y por secuenciación y análisis de exoma. Se obtuvieron diferentes variables de la historia clínica y se describió cada una de ellas.Resultados. Se describieron cuatro pacientes de sexo masculino con enfermedad granulomatosa crónica. En tres se encontró mutación del gen CYBB: dos tuvieron variantes patógenas sin sentido y el otro tuvo deleción de este gen y genes contiguos; el cuarto paciente mostró ausencia de expresión de la subunidad p47phox. Las madres de los tres pacientes con mutación en CYBB, resultaron portadoras. Los tres casos con alteraciones en CYBB presentaron infecciones graves y recurrentes, además de infección por el bacilo de Calmette-Guérin como manifestación inicial. El paciente con ausencia de p47phox presentó el cuadro clínico menos grave. Por el contrario, la deleción de CYBB y otros genes contiguos se asoció con un mal pronóstico. Ninguno de los pacientes recibió trasplante de células progenitoras hematopoyéticas.Conclusiones. En este grupo de pacientes, la enfermedad granulomatosa crónica causada por variantes patógenas en CYBB fue la más frecuente. A las madres portadoras se les debe hacer seguimiento clínico por el riesgo de manifestaciones inflamatorias, autoinmunitarias e infecciosas. Una de las primeras manifestaciones en los afectados fue la infección por el bacilo de Calmette-Guérin y, en países como México, en donde se aplica esta vacuna, los casos con reacciones adversas deben ser tamizados para descartar enfermedad granulomatosa crónica.
Primer estudio piloto para el tamizaje neonatal de linfopenias T y B en Colombia
Authors: Gutiérrez-Hincapié Sebastián , Muskus-López Carlos , Sánchez Isaura Pilar , Franco-Restrepo José Luis , Trujillo-Vargas Claudia M.
Published: January 2025

Introducción. La detección temprana de linfopenias congénitas facilitaría su tratamiento oportuno y la prevención de complicaciones serias, y optimizaría los recursos del sistema de salud.Objetivo. Realizar un estudio piloto para el tamizaje neonatal de linfopenias mediante la cuantificación de los círculos de escisión (TREC y KREC) de los receptores de los linfocitos T y B en muestras de sangre periférica de neonatos de Medellín, Colombia.Materiales y métodos. Se recolectaron muestras de 1.092 neonatos y de seis pacientes con sospecha de linfopenia, mediante pinchazo del talón o del dedo gordo del pie. Se extrajo el ADN y se midieron los niveles de TREC y KREC por qPCR. Resultados. En los seis pacientes con sospecha de linfopenia se encontraron niveles muy bajos o indetectables de TREC. Todos los neonatos tamizados presentaron niveles normales de TREC y KREC. Se observó concordancia entre los valores de TREC o de KREC en dos tipos diferentes de papel de filtro. Los niveles de TREC y KREC disminuyeron considerablemente después de 24 semanas de almacenamiento de las muestras de sangre en papel de filtro. Se encontró una asociación positiva entre los niveles de los TREC y el peso al nacer, y una correlación negativa entre los KREC y la edad gestacional. Los niveles de estos marcadores no se asociaron con el tipo de parto.Conclusiones. Se presenta el primer estudio piloto para el tamizaje temprano de linfopenias congénitas en neonatos en Colombia. Se propone el uso de un límite de detección de 119 y 69 copias/μl de sangre de TREC y KREC, respectivamente, para futuros programas de detección neonatal de linfopenias en el país.
Autoimmunity against cytokines: Double strike in autoimmune disease, a historical perspective
Authors: Insignares Iván , Rodríguez Luis E. , Correa-Jiménez Óscar , Alfaro-Murillo Alberto , Rincón-Arenas Laura , Sánchez Andrés , Múnera Marlon
Published: January 2025

Autoimmune responses are characterized by the development of antibodies and the activation of T lymphocytes against self-antigens. This leads to an effector immuneresponse against tissues expressing antigens, which are later recognized by the host immune system.Host antigens attacked by antibodies are called “autoantigens” and are of different kinds, including receptors, enzymes, and channel proteins. The autoimmune response is potentiated by cytokines that mediate the activation of Th1, Th2, or Th17 lymphocytes. The released cytokines can also be recognized as autoantigens, meaning they can be targets of the autoimmune response. The effects of autoimmunity on cytokines or their receptors are diverse, and the mechanisms of this type of autoimmune response are discussed in this review.
Identification of crucial extracellular genes as potential biomarkers in newly diagnosed Type 1 diabetes via integrated bioinformatics analysis
Authors: Gao Ming , Liu Qing , Zhang Lingyu , Tabak Fatema , Hua Yifei , Shao Wei , Li Yangyang , Qian Li , Liu Yu
Published: January 2025

Purpose

In this study, we aimed to study the role of extracellular proteins as biomarkers associated with newly diagnosed Type 1 diabetes (NT1D) diagnosis and prognosis.

Patients and Methods

We retrieved and analyzed the GSE55098 microarray dataset from the Gene Expression Omnibus (GEO) database. Using R software, we screened out the extracellular protein-differentially expressed genes (EP-DEGs) through several protein-related databases. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were applied to describe the role and function of these EP-DEGs. We used the STRING database to construct the interaction of proteins, Cytoscape software to visualize the protein-protein interaction (PPI) networks, and its plugin CytoHubba to identify the crucial genes between PPI networks. Finally, we used the comparative toxicogenomics database (CTD) to evaluate the connection between NT1D with the potential crucial genes and we validated our conclusions with another dataset (GSE33440) and some clinical samples.

Results

We identified 422 DEGs and 122 EP-DEGs from a dataset that includes (12) NT1D patients compared with (10) healthy people. Protein digestion and absorption, toll-like receptor signaling, and T cell receptor signaling were the most meaningful pathways defined by KEGG enrichment analyses. We recognized nine important extracellular genes: GZMB, CCL4, TNF, MMP9, CCL5, IFNG, CXCL1, GNLY, and LCN2. CTD analyses showed that LCN2, IFNG, and TNF had higher levels in NT1D and hypoglycemia; while TNF, IFNG and MMP9 increased in hyperglycemia. Further verification showed that LCN2, MMP9, TNF and IFNG were elevated in NT1D patients.

Conclusion

The nine identified key extracellular genes, particularly LCN2, IFNG, TNF, and MMP9, may be potential diagnostic biomarkers for NT1D. Our findings provide new insights into the molecular mechanisms and novel therapeutic targets of NT1D.
Efficacy of root canal treatment for autotransplanted third molars: a 6-Year cohort study of 167 teeth in southern China
Authors: Han Bangfeng , Liu Liu , Jiang Zhishen , Ye Li , Cao Yubin , Pan Jian
Published: January 2025

Background

Autogenous tooth transplantation offers significant advantages and promising success rates for replacing non-retainable teeth. This study aimed to investigate the prognostic factors, especially the impact of root canal treatment (RCT), of autotransplanted teeth in an up-to-6-year follow-up cohort of 167 teeth in Southern China.

Methods

We enrolled adult patients from the Southern Medical University-Shenzhen Stomatology Hospital between 2017 and 2023. Patients underwent autogenous tooth transplantation to replace non-retainable molars with upper or lower third molars with Moorrees tooth development stage ≥5. All surgical procedures were performed by an experienced surgeon. The included patients were followed up for 6~72 (median 28.5) months. Success, failure, and survival rate and prognostic factors were evaluated using univariable Kaplan-Meier, multivariable generalized linear regression, and multivariable COX regression analyses.

Results

The overall success rate is 97.6% with four unsuccessful cases. Herein, two of them were removed, leading to an overall survival rate of 98.8%. A total of 159 cases (95%) received RCT in 3 months. Univariable log-rank analysis showed that RCT (RR 0.109, 95%CI 0.010 to 1.202, P = 0.028) and site relationship between donor and receipt sites (RR 3.359, 95% CI [1.210–9.329], P = 0.020) were two significant prognostic factors of autotransplanted teeth. Multivariable generalized linear regression revealed that RCT is the only significant factor protecting the success rate of autotransplanted teeth (HR 0.003, 95% CI [0.000–0.249], P = 0.010). However, in the Cox regression model, the effects of RCT (HR 0.009, 95% CI [0.000–2.514], P = 0.101) did not reach statistical significance. Other factors did not demonstrate a significant impact in this cohort. These results supported that autogenous tooth transplantation is a viable alternative to conventional implant treatment with strict indications. Our findings underscore the importance of RCT in transplanted teeth with closed or semi-closed apices. Multi-center observational studies with larger sample size and extended follow-up duration may be needed to validate the conclusion.
Sanitização sobre a qualidade de sementes de algodoeiro
Authors: Silva Edcarlos Camilo da , Silva Hilderlande Florêncio da , Porcino Mirelly Miguel , Silva Jakeline Florêncio da , Nascimento Luciana Cordeiro do
Published: January 2025

A maioria dos patógenos transmitidos por sementes, podem causar grandes prejuízos durante as fases de desenvolvimento e produção da cultura. Objetivou-se determinar a eficiência da assepsia na qualidade sanitária e fisiológica de sementes de Gossypium hirsutum, tratadas com diferentes concentrações e combinações de produtos assépticos. Foram utilizadas sementes de duas cultivares de algodoeiro produzidas no município de Remígio, PB: BRS Rubi e BRS Aroeira. As sementes foram tratadas com água destilada esterilizada - ADE (controle) por 3 min (T0); NaClO 1% por 3 min + triplo enxágue com ADE (T1); NaClO 2% por 1 min + 1 enxágue com ADE (T2); álcool 70% por 30 segundos + triplo enxágue ADE + NaClO 0,5% por 1 min + triplo enxágue com ADE (T3); fungicida dicarboximida (T4) e álcool 70% por 30 segundos + NaClO 1% por 1 min + 1 enxágue com ADE por 1 min (T5). Foram realizados os testes de sanidade e germinação. Os tratamentos sanitizantes são indicados em sementes de algodoeiro para a redução de fungos, sem comprometer a qualidade fisiológica. Os tratamentos T1 e T2 promovem aumento na velocidade de germinação, sem afetar o vigor das sementes da cultivar BRS Rubi.
Perceived-Risk and Protective Factors in Suicidal Ideation and Attempt among Students in the Federal Polytechnic Offa Kwara State, Nigeria
Authors: Kolawole Ebenezer T. , Arulogun Oyedunni S.
Published: January 2025

Background: Suicide usually occurs in response to a situation that one views overwhelming. Nigerian university students encounter diverse economic, financial, social, and psychological challenges which could become overwhelming for them. Risk and protective factors give a clear view and targets for intervention in both individuals and communities.
Objective: The broad objective of the study was to investigate the perceived risk and protective factors of suicidal ideation and attempt among students in the Federal Polytechnic Offa.
Methods: A descriptive cross-sectional survey was conducted using a six-stage sampling technique, a total of 236 respondents were selected. Data on knowledge was analyzed using 18-point knowledge scale, a score of >11 was classified as a good knowledge and a score of <10 was classified as having poor knowledge. Data on perception was equally analyzed using 22 point perception scale, a score of >11 was classified as a good perception and a score of <10 was classified as having poor perception. Lastly, data on prevalence was analyzed using a four-point scale. A total mean score was estimated for each respondent. A mean score of 2.5 to 4.0 was classified as a high prevalence while a mean scores below 2.5 was considered a low prevalence. Data were analyzed using descriptive statistics and Chi-square test at p < 0.05.
Results: Ages of the respondents ranged from 15–30 years with a mean of 21.2±2.8 years. About 50.4% of the respondents were within the age of 15–19 years, and 53.4% were females. Moreover, 86.4% identified “Relationship breakups, shame, loss, defeat, humiliation, or threat” as risk factors, while 85.6% noted “Academic failures,” and 83.1% reported “Experiences of sexual violence or abuse.” Protective factors included “Being calm when faced with difficulties by relying on problem-solving abilities” (92.4%), “Practicing moral sanctions against suicide” (91.9%), and “Getting emotional help and support from family and friends” (83.1%).
Conclusion: When the risk factors are decreased, the tendency to have a thought or attempt suicide is generally decreased and increasing protective factors generally also decreases risk, therefore an holistic and multi-sectoral strategies that strengthen protective factors such as, resilience skills that increase awareness of reasons for living and problem-solving capabilities in individuals as well as promoting the development of supportive family and school environments are recommended.
Frequency of Uropathogenic Bacteria among Patients Visited to the National Reference University Hospital Center of N'Djamena (CHAD)
Authors: Doutoum Abdelsalam Adoum , Nazal Alhadj Markhous , Allamine Hisseine Mahamat , Ayambi Laguerre , Paul Assam Assam Jean , Tidjani Abdelsalam
Published: January 2025

Background: Urinary tract infections are among the most common bacterial infections, both in urban medicine and in hospitals where nosocomial urinary tract infections rank first or second among the main sites of infection.
Aims: The general objective of this study is to determine the frequency of urinary tract infections and the causative agents responsible for urinary tract infections in patients who came for consultation at the National Reference University Hospital of N'Djamena.
Methodology: This is a prospective cross-sectional study with non-probabilistic and consecutive sampling, conducted in the bacteriology unit of the National Reference University Hospital Center (NRUHC) in N'Djamena, between July and October 2023 and included all patients who had undergone a Cytobacteriological examination of urine.The identification of bacteria was based on morphological, cultural and biochemical characteristics.
Results: Of a total of 237 urine samples examined, 121 were positive with an overall frequency of 51% of which men represented 64% and women 36%. The most affected age group was [59-69] years for 27 % of participants. The minimum age of positive cases was 4 years, the maximum age was 90 years and a mean age of 53.64 years. The bacteriological frequency was 73% of Uropathogenic Enterobacteria, 23% of Gram-positive cocci, 2% of Cocco Bacilli and 2% of strict aerobic Bacilli. The main bacteria isolated were E. coli (45%), S. aureus (12%), Staphylococcus spp. (10%), K. pneumoniae (9%), Acinetobacter baumanii(4%), Raoultellaomithinolytica(3%).
Conclusion:Many germs can cause urinary tract infections due to pathogenicity factors specific to each.
Relevance of the Resourceful Human Management Concept in Employee Management at PT Bank Central Asia, Tbk
Authors: Pratama Vicky Alvindra , Sutanto Eddy Madiono
Published: January 2025

Employee management with the concept of resourceful humans is a new paradigm that holds immense potential. It focuses on developing potential, knowledge, and capabilities to significantly increase employee productivity and organizational contribution. This concept is yet to be fully implemented at PT Bank Central Asia. This research aims to uncover the most suitable concept of resourceful humans for application at PT Bank Central Asia, one that can bring about substantial improvements. The research employs a qualitative descriptive method with data collection through interviews and a systematic and comprehensive data analysis model. Effective employee management is crucial for ensuring employees have the ability and knowledge, providing opportunities for development and innovation, and fostering good relationships between employees and the company to create a conducive work environment that can motivate employees. Resourceful human management emerges as a promising concept for PT Bank Central Asia.
JUSTIFICATIVAS EM CAMPANHAS DE DESMONETIZAÇÃO CONTRA NOTÍCIAS FALSAS E DISCURSO DE ÓDIO: RESPOSTAS DO MOVIMENTO SLEEPING GIANTS BRASIL ÀS ACUSAÇÕES DE CENSURA
Authors: Paganotti Ivan
Published: January 2025

Inspirados em experiências internacionais do movimento Sleeping Giants, desde maio de 2020, usuários brasileiros de redes sociais como o Twitter têm denunciado anunciantes e plataformas de financiamento de sites acusados de disseminar desinformação e discurso de ódio. Este trabalho avalia quais os critérios apresentados para justificar essas campanhas de desmonetização, considerando como os responsáveis pelas contas do Sleeping Giants Brasil explicam suas escolhas de alvos e o que consideram ser notícias falsas e discurso ofensivo. O trabalho avalia como o movimento responde a críticas e questionamentos de usuários de redes sociais, esclarecendo suas escolhas, publicando conteúdos que funcionam como explicações de seus métodos e que são apresentados como materiais educativos para expor ao público as dificuldades na definição de limites para a liberdade de expressão em redes digitais.
QUEM SE LEMBRA DE JOÃO ALBERTO: EFEITOS DE AGENDAMENTO DA TV SOBRE UM CASO DE RACISMO
Authors: Gramacho Wladimir , Oliveira Carlos
Published: January 2025

Este artigo analisa efeitos de agendamento do Jornal Nacional e do Jornal da Record no caso do assassinato de João Alberto, em 2020, numa loja do Carrefour em Porto Alegre (RS). Classificamos e descrevemos o conteúdo de ambos os telejornais nos 14 dias subsequentes à morte de João Alberto e analisamos as respostas de 2017 indivíduos entrevistados em um survey online, aplicado em dezembro de 2020. Nossos achados mostram que os dois telejornais deram destaques muito distintos ao caso e a audiência de ambos os telejornais reagiu em conformidade com essa discrepância. Nossa análise estatística mostra que a lembrança do caso João Alberto está associada à exposição mais frequente ao JN, e não ao JR.
REFLEXÕES SOBRE AS RELAÇÕES ENTRE DOCUMENTARISTAS E ATORES SOCIAIS
Authors: Postali Thífani
Published: January 2025

O presente trabalho resulta de uma tese que se debruçou sobre o estudo da produção de filmes documentários que abordam questões sociais periféricas. Trata-se de um recorte que apresenta conceitos que trazem ao debate as possíveis relações estabelecidas entre documentaristas e atores sociais, utilizando a filosofia buberiana para nomeá-las e analisar seus impactos nos resultados de filmes documentários. Para tanto, se apoia no levantamento bibliográfico e na metodologia descritiva de cunho analítico. A partir dos conceitos e das ponderações de teóricos do cinema documentário, tais como Nichols, Gauthier, Freire e Ramos, o trabalho sustenta que a revelação da relação entre documentaristas e atores sociais pode servir como artifício para uma narrativa mais próxima da realidade ocorrida durante a produção fílmica.
COMPARTILHAMENTO DE DADOS PESSOAIS SENSÍVEIS ENTRE OS ÓRGÃOS DA ADMINISTRAÇÃO PÚBLICA:
Authors: Quarantini Leite Carolina , Barreiros de Carvalho Fonseca Alexandre
Published: January 2025

Em decorrência da exponencial evolução tecnológica e, consequentemente, maior veiculação de dados pessoais, este artigo científico possui como objetivo dissertar sobre o compartilhamento de dados sensíveis entre órgãos e entidades da Administração Pública mediante análise do Decreto nº 10.046/2019 à luz do julgamento da Arguição de Descumprimento de Preceito Fundamental nº 695 e Ação Direta de Inconstitucionalidade nº 6649/DF. Dessa forma, mediante pesquisa bibliográfica e documental, o presente artigo visa discutir o tratamento de dados pessoais sensíveis e, sobretudo, os limites para seu compartilhamento pelo Poder Público sob égide do princípio da proteção de dados pessoais e necessidade do acesso à informação.
COMUNICAÇÃO NÃO VIOLENTA COMO ALTERNATIVA PARA DESENVOLVIMENTO RESPONSÁVEL DO PODER FAMILIAR
Authors: Santos Renne Maria Isabel , Silva Rosa Victoria
Published: January 2025

O presente artigo se propõe a analisar como a Comunicação Não Violenta (CNV) interage com o exercício do poder familiar e o impacto desta coexistência na proteção da integridade física e emocional da criança e do adolescente. Além disso, utiliza da jurisprudência para o estudo sobre como a comunicação violenta descumpre direitos das crianças e adolescentes.
Artificial Intelligence In Personal Finance Management: Opportunities And Challenges
Authors: Gorai S.K. , . Amarmaurya
Published: January 2025

This researchpaper discusses howAI has been integrated into personalfinance management and transformed
how individuals deal with financial tasks. Budgeting, investment, and fraud prevention are no longer solely
dependent on traditional methods since AI tools have takencenter stage. The increasing complexity of personal
financial planning, fueled by issues such as retirement, healthcare, and environmental issues, demands more
complex approaches to managing money. Current AI applications are critically evaluated for their benefits and
the ethical challenges associated with this field. Through a study of cases on the Mint and Betterment, the
research illustrates how AI-powered tools increase efficiency and personalization. Ethical issues including data
privacy and algorithmic bias are addressed,together with emerging technologies such as Explainable AI (XAI) and blockchain integration. This report seeks to provide a comprehensive overview of the role AI can play in managing personal finance and its future developments.
Personalized Tourism Recommendation System: Leveraging GPT-3.5 For Comprehensive And Real-Time Travel Itineraries
Authors: Kumar Polisetty Narendra , Sanjay Pasumarthi Viswanadha , A Muthu Lakshmi
Published: January 2025

The Personalized Tourism Recommendation System harnesses the capabilities of GPT-3.5 to provide travelers
with comprehensive and real-time travel itineraries tailored to individual preferences and needs. As the travel
industry increasingly shifts toward personalized experiences, our system addresses this demand by integrating
advanced natural language processing with a wide array of travel data. Through user inputs such as interests,
budget, duration of travel, and desired activities, GPT-3.5 generates customized recommendations that
encompass accommodations, dining options, attractions, and transportation methods. The system continuously
learns from user feedback, improving its suggestions based on user satisfaction and behavioral trends. In addition
to generating itineraries, it incorporates real-time data such as weather forecasts, local events, and seasonal
attractions, ensuring that recommendations remain relevant and up-to-date. By employing a user-friendly
interface, travelers can interact with the system seamlessly, allowing for dynamic adjustments to their plans as
circumstances change. This innovative approach not only enhances user experience but also empowers travelers
to discover unique, off- the-beaten-path destinations, catering to diverse interests from adventure seekers to
cultural enthusiasts. The high accuracy and responsiveness of GPT-3.5 enable the generation of nuanced
recommendations that reflect local insights and personal preferences, setting our system apart from traditional
itinerary planners. Ultimately, the Personalized Tourism Recommendation System represents a significant
advancement in travel technology, aiming to transform how individuals plan their journeys by providing
personalized, engaging, and practical travel solutions that adapt in real-time, thus enriching the overall travel
experience. By leveraging cutting-edge artificial intelligence, we envision a future where every traveler's unique journey is just a few clicks away, driven by intelligent recommendations that foster exploration and discovery
Impacted Fish Bone In Throat: Tips To Share
Authors: Reddy Dr D. Sekhar
Published: January 2025

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A Comparative Study Of Ondansetron And Lignocaine To Alleviate The Pain Of Injection Propofol
Authors: Vivek Dr. G. Akshay , Goel Dr. Sharad , Sharma Dr. Shailja , Mishra Dr. Bishwa Prakash
Published: January 2025

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Role Of Vaginal Progesterone In Reducing Preterm Labour In Women With Short Cervix Identified In Mid Trimester Scan - Singleton Vs Twin Gestation: A Prospective Observational Comparative Study
Authors: Redishetty, Dr. Saritha , Palaparthi Dr. Sowmya , Pula Dr. Ravikanth , Kolar Dr. Geeta , Vavilala Dr.Suseela
Published: January 2025

Background
Preterm labor, especially in cases of short cervical length, is a major cause of neonatal morbidity and
mortality. Vaginal progesterone has been recognized as an effective treatment to reduce preterm labor risk.
However, its role in twin gestations needs further exploration.
Methods
This prospective observational comparative study was conducted at Fernandez Hospital, Hyderabad, from
August 2020 to August 2021. Women with singleton and twin pregnancies diagnosed with a short cervix
(cervical length <25mm) in the mid-trimester scan were administered vaginal progesterone (200 mg) daily, and
their cervical lengths were monitored weekly. Primary outcomes included preterm labor incidence and neonatal
outcomes.
Results
A total of 219 women were enrolled, with 146 in the singleton group and 73 in the twin group. The use of
vaginal progesterone significantly reduced preterm births before 34 weeks in the singleton group compared to
the twin group. NICU admissions and adverse neonatal outcomes were higher in the twin gestation group. Conclusion Vaginal progesterone is effective in lowering preterm labor risks in women with a short cervix, with better outcomes observed in singleton pregnancies compared to twin gestations.
Clinical And Echocardiography Outcomes Following Pericardiectomy In Chronic Constrictive Pericarditis
Authors: Hadiya Nootan , Kumar Madhur , Gupta Anubhav , Tyagi Ashish , Prashad Rimy
Published: January 2025

Introduction: Leading cause of chronic constrictive pericarditis differs according to geographic location,
tuberculosis remains the most common cause of constrictive pericarditis in Africa and Asia where as in western
country it remains a rare entity and idiopathic causes remains the most common etiology. Here our aim was to
study the clinical and echocardiography outcomes post pericardiectomy & compare it with other previous
clinical studies.
Methods: This is a retrospective study of 12 months with mean follow up period of 2.40 ± 2.01 years. PHILIPS
EPIQ7C machine was used for echocardiographic analysis. Mitral and tricuspid inflow velocities were detected
using PW doppler in apical 4-chamber view with sample volume of 2-4 mm.
Results: All the patients in the study population presented with dyspnea 19(100%). Annulus reversus was
observed in all our patients (19, 100%), which resolved completely postoperatively. Mean duration of hospital
stay was 26.63 ± 13.09 days with mean ICU stay of 5.89 ± 2.4 days.
Discussion: Different from international studies, we observed pericarditis in younger age group with mean age
of 26.58 ± 11.9 years which could be accountable to Tuberculosis in young generation in India, as also
observed by other indian studies. In our study, there was significant respiro-phasic variation in the mitral and
tricuspid E velocity in all patients.
Conclusions: Studies on detailed echocardiographic evaluation in terms of various parameters like mitral and tricuspid E velocities and tissue doppler imaging are sparce. This study adds to the important role of echocardiography in assessment of chronic constrictive pericarditis.
Outcome of Arthroscopic Reconstruction of Anterior Cruciate Ligament Injury: A Comparison of Peroneus Longus Tendon and Semitendinosus-Gracilis Tendon Autograft
Authors: Munzoor-Al-Mahmud Dr. Md. Rifat , Islam Prof. Dr. Md. Nazrul , Roy Prof. Dr. Naresh Kumar , Rahman Dr. Mohammed Abdur , Arifuzzaman Dr.
Published: January 2025

Background: Outcome studies on ACL reconstruction have assessed and compared different surgical techniques.
Aim of the study: This study aimed to compare the outcomes of anterior cruciate ligament restoration with
semitendinosus-gracilis tendon autograft and peroneus longus tendon autograft at 2 years post-surgery. Methods:
This study was conducted in Department of Orthopaedics & Traumatology, TMSS Medical College & Rafatullah
Community Hospital (TMC & RCH), Bogura, Bangladesh, Uttara Adhunik Medical College and Hospital, Uttara,
Dhaka., Bangladesh & Enam Medical College Hospital, Savar, Dhaka, Bangladesh. A prospective examination
was conducted on 50 patients with isolated anterior cruciate ligament damage who had peroneus longus tendon
autograft reconstruction. Out of these, 42 patients were followed up. The semitendinosus-gracilis tendon autograft
group consisted of 50 consecutive patients who met the same criteria, with 45 accessible for follow-up. All data
was gathered, documented in a Microsoft Excel spreadsheet, and analyzed with descriptive statistics in SPSS 16.0.
All data was collected, documented in a Microsoft Excel work sheet, and analyzed using descriptive statistics in
SPSS 16.0. Results: Ninety percent of patients with peroneus longus tendon had good or excellent results, while
91% had good or excellent results with semitendinosus-gracilis tendon. 86% of patients in the peroneus longus
tendon group were assessed as normal or if patients with ruptures or atraumatic failures were assumed to have
scored grade D, then there were 82% in the peroneus longus group and 89% in the semitendinosus-gracilis tendon
group scoring grade A or B. There was no significant difference between the peroneus longus and semitendinosusgracilis tendon groups in any of the other IKDC subcategories at 2 years. In the hamstring tendon group anterior
kneeling pain was present in 6% at both 1 and 2 years (P < 0.0002). Conclusion: In terms of clinical stability,
range of motion, and general symptoms, patients undergoing ACL restoration with a semitendinosus-gracilis
tendon graft had the same outcome as those receiving a peroneus longus tendon graft. There was no difference in the return to level I or II sports, while more peroneus longus tendon patients reached level I
Double Outlet Right Ventricle With Intact Ventricular Septum And Interrupted Aortic Arch: A Case Study Of A Foetus With Trisomy 18
Authors: Yaisana Dr. Akoijam , Devi Dr. Aribam Jaishree , Soraisam Dr. Purnabati , Singh Dr. Thounaojam Oken , Phairembam Dr. Ashish
Published: January 2025

Background: 90% of the infants with trisomy 18 suffers from congenital heart defects. Double outlet right
ventricle (DORV) is a rare form of congenital heart disease where both the arterial roots arise from the right
ventricle. Interrupted aortic arch (IAA) is an extremely rare congenital anomaly representing approximately 1%
of congenital heart disease, characterised by lack of luminal continuity between the ascending and descending
thoracic aorta
Case Report: A still born male foetus of around 20 weeks gestation, weighing 238g with trisomy 18 was
collected from the Obstetrics and Gynaecology Department, RIMS, Imphal. On dissection, both the great
arteries are committed to the right ventricle and are unobstructed. The aorta arose right to the pulmonary trunk
and is interrupted distal to the left subclavian artery. Pulmonary-aortic connection is maintained by a large
patent ductus arteriosus. The mitral valve was atretic. The left ventricle was hypoplastic.
Conclusion: We found this case notable as this is an exceedingly rare case of DORV with intact ventricular septum, in the setting of mitral atresia, hypoplastic left ventricle associated to type A, IAA in Trisomy 18
Optimisation Des Echanges Des Données Administratives Au Sein De La Commune « Cas De La Commune Urbano Rurale De Lubunga/Tshopo/RD Congo»
Authors: Charles Sont Par Muhindo Kamuha Jonathan Et Kabuyaya Kalungero
Published: January 2025

L’optimisation des échanges des données administratives au sein de l’une des communes de la Thopo fait l’objet
de cette étude. L’objectif de cet article est d’améliorer la qualité de travail des agents de cette commune en créant
un climat social d’harmonie c’est à dire en formant les agents sur la vie en société et le NTIC, en modernisant les services c'est-à-dire en donnant accès à tous les services l’information via un réseau LAN sécurisé et équiper la commune des logiciels adaptés aux divers services
ER‐to‐lysosome‐associated degradation in a nutshell: mammalian, yeast, and plant ER‐phagy as induced by misfolded proteins
Authors: Rudinskiy Mikhail , Molinari Maurizio
Published: June 2023

Conserved catabolic pathways operate to remove aberrant polypeptides from the endoplasmic reticulum (ER), the major biosynthetic organelle of eukaryotic cells. The best known are the ER‐associated degradation (ERAD) pathways that control the retrotranslocation of terminally misfolded proteins across the ER membrane for clearance by the cytoplasmic ubiquitin/proteasome system. In this review, we catalog folding‐defective mammalian, yeast, and plant proteins that fail to engage ERAD machineries. We describe that they rather segregate in ER subdomains that eventually vesiculate. These ER‐derived vesicles are captured by double membrane autophagosomes, engulfed by endolysosomes/vacuoles, or fused with degradative organelles to clear cells from their toxic cargo. These client‐specific, mechanistically diverse ER‐phagy pathways are grouped under the umbrella term of ER‐to‐lysosome‐associated degradation for description in this essay.
Reducing scan time in 177Lu planar scintigraphy using convolutional neural network: A Monte Carlo simulation study
Authors: Yang Ching‐Ching , Ko Kuan‐Yin , Lin Pei‐Yao
Published: June 2023

Purpose

The aim of this study was to reduce scan time in 177Lu planar scintigraphy through the use of convolutional neural network (CNN) to facilitate personalized dosimetry for 177Lu‐based peptide receptor radionuclide therapy.

Methods

The CNN model used in this work was based on DenseNet, and the training and testing datasets were generated from Monte Carlo simulation. The CNN input images (IMGinput) consisted of 177Lu planar scintigraphy that contained 10–90% of the total photon counts, while the corresponding full‐count images (IMG100%) were used as the CNN label images. Two‐sample t‐test was conducted to compare the difference in pixel intensities within region of interest between IMG100% and CNN output images (IMGoutput).

Results

No difference was found in IMGoutput for rods with diameters ranging from 13 to 33 mm in the Derenzo phantom with a target‐to‐background ratio of 20:1, while statistically significant differences were found in IMGoutput for the 10‐mm diameter rods when IMGinput containing 10% to 60% of the total photon counts were denoised. Statistically significant differences were found in IMGoutput for both right and left kidneys in the NCAT phantom when IMGinput containing 10% of the total photon counts were denoised. No statistically significant differences were found in IMGoutput for any other source organs in the NCAT phantom.

Conclusion

Our results showed that the proposed method can reduce scan time by up to 70% for objects larger than 13 mm, making it a useful tool for personalized dosimetry in 177Lu‐based peptide receptor radionuclide therapy in clinical practice.
Age categorization and stereotyping at work
Authors: Pecher Diane , van Mierlo Heleen , Romers C. M. , Feersma Hoekstra K. , Possel Naomi , Bouwmeester Samantha
Published: June 2023

Age stereotyping at the workplace can lead to discrimination. We investigated stereotype influence on recall. In the who‐said‐what paradigm participants studied older and younger speakers making stereotypical and counterstereotypical statements about their work, followed by memory tests for the statements and speakers. Statements were more likely attributed to a speaker from the same age category than the other age category, replicating earlier findings. Stereotypicality had no effect on statement recognition but participants were more likely to guess a stereotypical speaker even though speakers made equal numbers of stereotypical and counterstereotypical statements (Experiments 1 and 3). When speakers made more counterstereotypical statements (Experiment 2) this bias was reduced but less so than the actual proportion of stereotypical statements warranted. Speaker judgments were also influenced by prior stereotypes. We conclude that participants used prior stereotypes to supplement recall from memory. Measures to reduce stereotypes should include procedures to improve memory accuracy.
Same crime, same time? Differences in visual maturity affect opinions of adolescent culpability
Authors: Koch Mary Kate , Burd Kayla A. , Mendle Jane
Published: June 2023

Early pubertal maturation is associated with earlier contact with the juvenile justice system. In two studies (Total N = 782), we examined whether youth presumed to have committed a crime and who appear physically older than their chronological age were held to different standards of legal responsibility while accounting for race and sex. Participants read a vignette detailing situations in which a crime was committed and decided whether to call the police (Study 1) or make sentencing recommendations (Study 2). Participants were more likely to call the police on youth who appeared more physically developed and on boys. Less visibly mature youth and girls were assigned behavioral explanations that deemphasized agency. White youth were sentenced to more hours of community service than Black youth. We discuss potential implications of these findings in real‐world contexts such as police decision‐making.
Adaptive neural boundary control for state constrained flexible manipulators
Authors: Zhang Xing‐Yu , Li Yuan‐Xin
Published: June 2023

This article discusses the adaptive neural tracking control issue for a flexible manipulator system with time‐varying full‐state constraints. First, the flexible manipulator system is modeled using partial differential equations with boundary conditions. Second, neural network techniques are used to deal with unknown nonlinear functions. Based on the backstepping technique, an adaptive neural boundary controller is developed that effectively suppresses the effects of input saturation. Moreover, the construction of the asymmetric time‐varying barrier Lyapunov function guarantees that the full‐state constraints of the system are met and that the closed‐loop system signals remain bounded. Finally, simulations are performed, and the results demonstrate the efficacy of the proposed approach.
Bioinspired Artificial Visual System Based on 2D WSe2 Synapse Array
Authors: Gong Yue , Xie Peng , Xing Xuechao , Lv Ziyu , Xie Tao , Zhu Shirui , Hsu Hsiao‐Hsuan , Zhou Ye , Han Su‐Ting
Published: June 2023

Machine vision systems that capture images for visual inspection and recognition tasks must be able to perceive, memorize, and compute any color scene. To achieve this, most of the current visual systems use circuits and algorithms which may reduce efficiency and increase complexity. Herein, a 2D semiconductor tungsten diselenide (WSe2)‐based phototransistor that successfully demonstrates an artificial vision system integrating the processing capability of visual information sensing memory, is reported. Furthermore, based on a 6 × 6 fabricated retinal perception array, artificial visual information sensing memory and processing system are proposed to perform image recognition tasks, which can avoid the time delay and energy consumption caused by data conversion and movement. On the other hand, highly linear symmetric synaptic plasticity can be achieved based on the modulation of carrier types in WSe2 transistors with different thicknesses, facilitating the high level of training and inference accuracy for artificial neural networks. Last, through training and inference simulations, the feasibility of the hybrid synapses for optical neural networks (ONN) is demonstrated.
Nanoporous Membrane Electrodes with an Ordered Array of Hollow Giant Carbon Nanotubes
Authors: Liu Hongyu , Pan Zheng‐Ze , Aziz Alex , Tang Rui , Lv Wei , Nishihara Hirotomo
Published: June 2023

This study proposes a next‐generation model membrane electrode for fundamental electrochemical research of amorphous‐based porous carbon materials. This novel electrode is fabricated by the uniform carbon coating of anodic aluminum oxide formed on an Al substrate and free from a barrier layer. The conformally carbon‐coated layer forms vertically aligned giant carbon nanotubes, and their walls comprise low‐crystalline stacked graphene sheets. The diameter and the length of the nanopores can be tuned over a broad range of between 10 to 200 nm and 2 to 90 µm, respectively. Moreover, unlike composite electrodes made from other ordered nanoporous carbons, this model electrode exhibits an absence of inter‐particle spacing and hence no contact resistance between particles. Thus, this model electrode provides representative nanopores of low‐crystalline carbon materials. An atomic‐scale structural model of the low‐crystalline carbon walls is built with the aid of an in‐house temperature‐programmed desorption system to enable theoretical simulations to be performed. Using this model electrode, the electrical conductivity of low‐crystalline carbon walls and mass transportation in an electric double‐layer system are elucidated. This representative model electrode is expected to help clarify the complex electrochemical processes in porous carbon electrodes.
Seeded Synthesis of Hollow PdSn Intermetallic Nanomaterials for Highly Efficient Electrocatalytic Glycerol Oxidation
Authors: Huang Biao , Ge Yiyao , Zhang An , Zhu Shangqian , Chen Bo , Li Guanxing , Yun Qinbai , Huang Zhiqi , Shi Zhenyu , Zhou Xichen , Li Lujiang , Wang Xixi , Wang Gang , Guan Zhiqiang , Zhai Li , Luo Qinxin , Li Zijian , Lu Shiyao , Chen Ye , Lee Chun‐Sing , Han Yu , Shao Minhua , Zhang Hua
Published: June 2023

Intermetallic nanomaterials have shown promising potential as high‐performance catalysts in various catalytic reactions due to their unconventional crystal phases with ordered atomic arrangements. However, controlled synthesis of intermetallic nanomaterials with tunable crystal phases and unique hollow morphologies remains a challenge. Here, a seeded method is developed to synthesize hollow PdSn intermetallic nanoparticles (NPs) with two different intermetallic phases, that is, orthorhombic Pd2Sn and monoclinic Pd3Sn2. Benefiting from the rational regulation of the crystal phase and morphology, the obtained hollow orthorhombic Pd2Sn NPs deliver excellent electrocatalytic performance toward glycerol oxidation reaction (GOR), outperforming solid orthorhombic Pd2Sn NPs, hollow monoclinic Pd3Sn2 NPs, and commercial Pd/C, which places it among the best reported Pd‐based GOR electrocatalysts. The reaction mechanism of GOR using the hollow orthorhombic Pd2Sn as the catalyst is investigated by operando infrared reflection absorption spectroscopy, which reveals that the hollow orthorhombic Pd2Sn catalyst cleaves the CC bond more easily compared to the commercial Pd/C. This work can pave an appealing route to the controlled synthesis of diverse novel intermetallic nanomaterials with hollow morphology for various promising applications.
Organic Sonodynamic Materials for Combination Cancer Immunotherapy
Authors: Zhang Chi , Pu Kanyi
Published: June 2023

Sonodynamic therapy (SDT) is a promising non‐invasive therapeutic modality to treat deep‐seated tumors owing to the good tissue penetration ability and spatiotemporal controllability of ultrasound (US); however, the low sonodynamic activity and potential side effects greatly limit its clinical translation. Cancer immunotherapy that leverages the immune system to fight against cancer has great potential to synergize with SDT for the treatment of cancer with high efficiency and safety. In this review, the convergence of SDT with cancer immunotherapy to exert their merits and break through the limitations of combination cancer sono‐immunotherapy are discussed. The focus is on the development and construction of organic materials with high sonodynamic activity and immunotherapeutic efficiency. These organic materials not only induce immunogenic cell death to improve tumor immunogenicity via SDT but also activate antitumor immunity via immuno‐oncology drug‐mediated immune pathway modulation. The combination of various immuno‐oncology drugs with organic sonosensitizers is categorized and discussed along with the prospects and challenges for clinical translation.