bluuebunny/crossref_metadata_2025 huggingface dataset:
Visual feedback-dependent modulation of arousal, postural control, and muscle stretch reflexes assessed in real and virtual environments
Authors: Hodgson Daniel D. , King Jordan A. , Darici Osman , Dalton Brian H. , Cleworth Taylor W. , Cluff Tyler , Peters Ryan M.
Published: April 2023

Introduction

The mechanisms regulating neuromuscular control of standing balance can be influenced by visual sensory feedback and arousal. Virtual reality (VR) is a cutting-edge tool for probing the neural control of balance and its dependence on visual feedback, but whether VR induces neuromodulation akin to that seen in real environments (eyes open vs. closed or ground level vs. height platform) remains unclear.

Methods

Here we monitored 20 healthy young adults (mean age 23.3 ± 3.2 years; 10 females) during four conditions of quiet standing. Two real world conditions (eyes open and eyes closed; REO and REC) preceded two eyes-open virtual ‘low’ (ground level; VRL) and ‘high’ (14 m height platform; VRH) conditions. We measured arousal via electrodermal activity and psychosocial questionnaires rating perceived fear and anxiety. We recorded surface electromyography over the right soleus, medial gastrocnemius, and tibialis anterior, and performed force plate posturography. As a proxy for modulations in neural control, we assessed lower limb reflexive muscle responses evoked by tendon vibration and electrical stimulation.

Results

Physiological and perceptual indicators of fear and anxiety increased in the VRH condition. Background soleus muscle activation was not different across conditions; however, significant increases in muscle activity were observed for medial gastrocnemius and tibialis anterior in VRH relative to REO. The mean power frequency of postural sway also increased in the VRH condition relative to REO. Finally, with a fixed stimulus level across conditions, mechanically evoked reflexes remained constant, while H-reflex amplitudes decreased in strength within virtual reality.

Discussion

Notably, H-reflexes were lower in the VRL condition than REO, suggesting that these ostensibly similar visual environments produce different states of reflexive balance control. In summary, we provide novel evidence that VR can be used to modulate upright postural control, but caution that standing balance in analogous real and virtual environments may involve different neural control states.
Supplementation of hyaluronic acid injections with vitamin D improve knee function by attenuating synovial fluid oxidative stress in osteoarthritis patients with vitamin D insufficiency
Authors: Shen Jianlin , Lin Xiaoning , Lin Yujin , Xiao Jiecheng , Wu Changfu , Zheng Feng , Wu Xianwei , Lin Haibin , Chen Guoli , Liu Huan
Published: April 2023

Objectives

There is still controversy about the effect of vitamin D supplementation on osteoarthritis (OA). The purpose of this study was to investigate the effects of vitamin D supplementation with Hyaluronic acid (HA) injection on OA.

Methods

We investigated serum vitamin D levels and oxidative stress (OS) in synovial fluid from patients with OA who underwent total knee arthroplasty (grade IV, n = 24) and HA injection (grade II and III, n = 40). The effects of HA injection with or without oral vitamin D supplementation on synovial fluid OS and knee pain and function were then further investigated. Finally, patients underwent HA injection were divided into two groups according to vitamin D levels (vitamin D < or > 30 ng/ml), and the efficacy of the two groups were compared.

Results

The results showed that the levels of glutathione peroxidase (GSH-PX) (P < 0.05) in the synovial fluid were lower in patients with stage IV OA than that in patients with stage II-III OA, while the levels of malondialdehyde (MDA) (P < 0.05) and lactate dehydrogenase (LDH) (P < 0.01) were significantly higher. Moreover, we found that age, BMI and vitamin D levels were significantly associated with the levels of oxidants and/or antioxidants in synovial fluid, and that vitamin D was significantly negatively correlated with BMI (R = −0.3527, p = 0.0043). Supplementation of HA injections with vitamin D significantly reduced the OS status in synovial fluid, attenuated knee pain and improved knee function in OA patients with vitamin D insufficiency.

Conclusion

We conclude that maintenance of vitamin D sufficiency may be beneficial for the treatment of OA by improving OS in synovial fluid.
The efficacy and safety of nirsevimab for the prevention of RSV infection among infants: A systematic review and meta-analysis
Authors: Turalde-Mapili Maria Wilma R. , Mapili Jerahmeel Aleson L. , Turalde Christian Wilson R. , Pagcatipunan Marimel R.
Published: April 2023

Background

Respiratory syncytial virus (RSV) is a leading cause of morbidity and mortality among infants with a global incidence of 9.5% and a mortality rate of 2.2%. The management of RSV infection is mainly supportive and, aside from emerging monoclonal antibodies, there has been no benefit of most preventive measures. Recent evidence suggests the potential of nirsevimab in preventing RSV infection.

Objective

This study aims to determine the efficacy and safety of nirsevimab in preventing RSV infection among infants using a review of relevant clinical trials.

Methods

We performed a random-effects meta-analysis among infants comparing nirsevimab injection vs. placebo. MEDLINE, CENTRAL, Scopus, and ClinicalTrials.gov were searched for relevant trials from inception to June 2022. The selected studies were assessed for risk of bias using the Revised Cochrane Risk-of-Bias (RoB2) tool and for quality of evidence using the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) approach.

Results

Two studies were included. Data analysis showed that among infants, nirsevimab given before the RSV season significantly reduced the risk of medically attended RSV-related infection (RR: 0.26; 95% CI: 0.18–0.38) and the risk of hospitalization due to RSV infection (RR: 0.24; 95% CI: 0.13–0.47). There was no difference in terms of adverse events leading to death (RR: 0.78, 95% CI: 0.20–2.98) and adverse events of special interest (RR: 0.92, 95% CI: 0.25–3.38).

Conclusions

The use of nirsevimab to prevent RSV infections and hospitalization shows its promising potential, but studies on its cost-effectiveness are lacking. We recommend that further studies be done to look into the applicability and cost-effectiveness of nirsevimab.
The safety of sports in children with inherited arrhythmia substrates
Authors: Katyal Abhay , Li Christopher O. Y. , Franciosi Sonia , Sanatani Shubhayan
Published: April 2023

Sudden cardiac death (SCD) is a rare and devastating event in children and remains a leading cause of death in young athletes. Channelopathies and cardiomyopathies, in particular long QT syndrome (LQTS), catecholaminergic polymorphic ventricular tachycardia (CPVT), hypertrophic cardiomyopathy (HCM), and arrhythmogenic cardiomyopathy (ACM) are associated with exercise-related SCD. Implantable cardioverter-defibrillators (ICDs) are often placed for secondary prevention for athletes with cardiomyopathy or channelopathy. There remains concern regarding the safety of return to participation with an ICD in place. Guidelines have historically recommended that patients with inherited heart rhythm disorders be restricted from competitive sports participation. Increasing evidence suggests a lower risk of exercise-related cardiac events in young athletes with inherited heart rhythm disorders. In this review, we highlight current knowledge, evolving guidelines, and present a multidisciplinary approach involving shared decision-making and appropriate planning for safe sports participation of children with inherited heart rhythm disorders.
Impact of traditional East Asian medicine as an add-on therapy on survival and recurrence after surgery for breast cancer: A systematic review and meta-analysis
Authors: Yoon Jee-Hyun , Kim Eun Hye , Park Su Bin , Jin Hayun , Yoon Seong Woo
Published: April 2023

Background: Breast cancer is the most common cancer in women. Patients with cancer increasingly incorporate complementary and alternative medicines, including traditional East Asian medicine (TEAM), for cancer prevention and treatment. This review aimed to determine the effectiveness and safety of TEAM for survival and recurrence after surgery in patients with breast cancer.

Methods: We searched nine electronic databases up to 25 August 2022, for randomized controlled trials (RCTs) of TEAM to prevent the recurrence of breast cancer in female patients after mastectomy or breast-conserving surgery. The primary outcome was 5-year disease-free survival (DFS), and secondary outcomes were 5-year overall survival, locoregional and distant recurrence rates, and toxicity. This study adhered to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to evaluate the quality of evidence.

Results: From 368 citations, data from nine studies reporting on a total of 1240 patients were included in the systematic review, and eight studies were deemed suitable for the meta-analysis. TEAM combined with adjuvant chemotherapy showed a significant improvement in DFS (odds ratio [OR] 0.42%, 95% confidence interval [CI] 0.28 to 0.61, p < 0.00001) and overall survival (OR 0.44%, 95% CI 0.27 to 0.73, p = 0.001) compared to adjuvant chemotherapy alone. The reduction in the rate of total recurrence was favorable for TEAM combined with adjuvant chemotherapy compared to adjuvant chemotherapy alone (Risk ratio 0.49%, 95% CI 0.35 to 0.70; p < 0.0001). TEAM after adjuvant chemotherapy showed a significant advantage in DFS compared to no TEAM (OR 0.61%, 95% CI 0.41 to 0.92, p = 0.02). No severe adverse events related to TEAM were reported. The overall certainty of the evidence for DFS, overall survival, and the total recurrence rate were moderate when postoperative breast cancer patients used TEAM combined with adjuvant chemotherapy.

Conclusion: Moderate-quality evidence suggests TEAM as an add-on therapy to adjuvant chemotherapy. TEAM may have the potential to improve long-term survival and prevent postoperative recurrence in patients with breast cancer. In future, more rigorous RCTs should be conducted to confirm these findings.
Low-dose of caffeine alleviates high altitude pulmonary edema via regulating mitochondrial quality control process in AT1 cells
Authors: Tian Liuyang , Jia Zhilong , Yan Yan , Jia Qian , Shi Wenjie , Cui Saijia , Chen Huining , Han Yang , Zhao Xiaojing , He Kunlun
Published: April 2023

Backgrounds: High-altitude pulmonary edema (HAPE) is a life-threatening disease without effective drugs. Caffeine is a small molecule compound with antioxidant biological activity used to treat respiratory distress syndrome. However, it is unclear whether caffeine plays a role in alleviating HAPE.

Methods: We combined a series of biological experiments and label-free quantitative proteomics analysis to detect the effect of caffeine on treating HAPE and explore its mechanism in vivo and in vitro.

Results: Dry and wet weight ratio and HE staining of pulmonary tissues showed that the HAPE model was constructed successfully, and caffeine relieved pulmonary edema. The proteomic results of mice lungs indicated that regulating mitochondria might be the mechanism by which caffeine reduced HAPE. We found that caffeine blocked the reduction of ATP production and oxygen consumption rate, decreased ROS accumulation, and stabilized mitochondrial membrane potential to protect AT1 cells from oxidative stress damage under hypoxia. Caffeine promoted the PINK1/parkin-dependent mitophagy and enhanced mitochondrial fission to maintain the mitochondria quality control process.

Conclusion: Low-dose of caffeine alleviated HAPE by promoting PINK1/parkin-dependent mitophagy and mitochondrial fission to control the mitochondria quality. Therefore, caffeine could be a potential treatment for HAPE.
Immune cell death-related lncRNA signature as a predictive factor of clinical outcomes and immune checkpoints in gastric cancer
Authors: Zhang Zeyu , Su Duntao , Thakur Abhimanyu , Zhang Kui , Xia Fada , Yan Yuanliang
Published: April 2023

Background: Immune cell death (ICD) is a type of tumor cell death that has recently been shown to activate and regulate tumor immunity. However, the role of ICD-related long non-coding RNAs (lncRNAs) in gastric cancer remains to be clarified.

Methods: We obtained 375 tumor samples from the Cancer Genome Atlas (TCGA) database and randomly assigned them to training and verification groups. LASSO and Cox regression analysis were utilized to identify ICD-related lncRNAs and establish a risk model. The changes in the immune microenvironment of the two groups were compared by examining the tumor-infiltrating immune cells.

Results: We established a tumor signature based on nine ICD-related lncRNAs. In light of the receiver operating characteristic and Kaplan–Meier curves, the prognostic values of this risk model were verified. Multivariate regression analysis showed that the risk score was an independent risk factor for the prognosis of patients in both the training cohort (HR 2.52; 95% CI: 1.65–3.87) and validation cohort (HR 2.70; 95% CI: 1.54–4.8). A nomogram was developed to predict the 1-, 3-, and 5-year survival of patients with gastric cancer, and the signature was linked to high levels of immunological checkpoint expression (B7-H3, VSIR).

Conclusions: An ICD-related lncRNA signature could predict the immune response and prognosis of patients with gastric cancer. This prognostic signature could be employed to independently monitor the efficacy of immunotherapy for gastric cancer patients.
Exploring the influence of target atomic number (Z2) on mean equilibrium charge state (q¯: A comprehensive study
Authors: Swami D. K. , Kumar Sarvesh , Singh Balwinder , Karn R. K.
Published: April 2023

We have investigated the effect of the target atomic number Z2 on the mean charge state (q¯ using various model predictions such as the Shima–Ishihara –Mikumo, Ziegler–Biersack–Littmark, Schiwietz, Schiwietz–Grande , Fermi-gas-models and theoretical codes with experimental data available in the literature. This investigation makes it possible to determine the best-fit model to calculate q¯. In this work, we discuss the post-collision charge state distribution in different targets used as thin films and projectile beams (Fq+, Siq+, Clq+, and Cuq+) with different charge states (available in literature). A detailed overview of such collision experiments has been explored over a wide energy range of 1.07–3.93 MeV/u. In this contribution, an overview of the mean charge state dependence on the Fermi velocity of target materials is provided. Finally, the influence of the non-radiative electron capture at the target exit surface on the projectile charge state distribution for fast projectiles in different targets is shown, and a comparison is made with experimental data.
Multiple targets related to mitochondrial function unveiled by metabolomics and proteomics profiles of hearts from atrial fibrillation patients
Authors: Liu Weizhuo , Hu Bo , Wang Yuliang , Zhang Xiaobin , Zhu Miao , Shi Yu , Guo Changfa , Zhang Yangyang
Published: April 2023

Background: The prominent mitochondrial metabolic changes of the atrium reportedly have significant impact on electrical signals and structural remodeling which play important roles in the occurrence and development of atrial fibrillation (AF). However, the mechanism is not completely known.

Objective: This study was aimed to explore the mitochondrial metabolism reprogrammed in AF patients by integrating metabolomics as well as proteomics of human atrium tissues.

Methods and Results: Left atrial tissue samples were harvested from 10 non-valvular AF patients and 10 matched samples from healthy donors for transplantation. In metabolomics analysis, 113 metabolites were upregulated and 10 metabolites were downregulated in AF, where multiple pathways related to mitochondrial energy metabolism were enriched. Correlation analysis between the differentially expressed proteins and metabolites identified several hub proteins related to mitochondrial function including Glycerol-3-phosphate dehydrogenase 2 (GPD2), Synemin (SYNM), Plectin (PLEC), with MCC score of 27, 17, 16, respectively, which have the most interactions with the dysregulated metabolites and ranked at the top in network string interactions scored by MCC method. All 330 differentially expressed proteins including 225 upregulated and 105 downregulated molecules were revealed and analyzed, which identified the downregulation of GPD2 (p = 0.02 and FC = 0.77), PLEC (p < 0.001 and FC = 0.71) and SYNM (p = 0.04 and FC = 0.76) in AF patients. Gene Set Variation Analysis (GSEA) showed mitochondrial metabolism-associated pathways including oxidative phosphorylation (NES: −1.73) and ATP biosynthetic process (NES: −2.29), were dramatically diversified in human AF. In GSVA, the expression levels of GPD2, PLEC, and SYNM were demonstrated to be associated with multiple metabolic pathways related to mitochondrial function (e.g., lipid metabolism and AMP activated protein kinase signaling) and cardiac structural and electrical remodeling (e.g., contractile fiber, ion homeostasis), which were proven vital in the development and maintenance of AF.

Conclusion: In all, this study provides new insights into understanding the mechanisms of AF progression, especially the reprogramming mitochondrial metabolism, and identifies several genes related to mitochondrial function as novel targets for AF, which may be involved in the occurrence and development of AF.
C-type natriuretic peptide (CNP) in the paraventricular nucleus-mediated renal sympatho-inhibition
Authors: Zheng Hong , Patel Tapan A. , Liu Xuefei , Patel Kaushik P.
Published: April 2023

Volume reflex produces sympatho-inhibition that is mediated by the hypothalamic paraventricular nucleus (PVN). However, the mechanisms for the sympatho-inhibitory role of the PVN and the neurochemical factors involved remain to be identified. In this study, we proposed C-type natriuretic peptide (CNP) as a potential mediator of this sympatho-inhibition within the PVN. Microinjection of CNP (1.0 μg) into the PVN significantly decreased renal sympathetic nerve activity (RSNA) (−25.8% ± 1.8% vs. −3.6% ± 1.5%), mean arterial pressure (−15.0 ± 1.9 vs. −0.1 ± 0.9 mmHg) and heart rate (−23.6 ± 3.5 vs. −0.3 ± 0.9 beats/min) compared with microinjection of vehicle. Picoinjection of CNP significantly decreased the basal discharge of extracellular single-unit recordings in 5/6 (83%) rostral ventrolateral medulla (RVLM)-projecting PVN neurons and in 6/13 (46%) of the neurons that were not antidromically activated from the RVLM. We also observed that natriuretic peptide receptor type C (NPR-C) was present on the RVLM projecting PVN neurons detected by dual-labeling with retrograde tracer. Prior NPR-C siRNA microinjection into the PVN significantly blunted the decrease in RSNA to CNP microinjections into the PVN. Volume expansion-mediated reduction in RSNA was significantly blunted by prior administration of NPR-C siRNA into the PVN. These results suggest a potential role for CNP within the PVN in regulating RSNA, specifically under physiological conditions of alterations in fluid balance.
Intraspecific chemodiversity provides plant individual- and neighbourhood-mediated associational resistance towards aphids
Authors: Ziaja Dominik , Müller Caroline
Published: April 2023

Some plant species express an extraordinarily high intraspecific diversity in phytochemicals (= chemodiversity). As discussed for biodiversity, higher chemodiversity may provide better protection against environmental stress, including herbivory. However, little is known about whether the resistance of a plant individual towards herbivores is mostly governed by its own chemodiversity or by associational resistance provided by conspecific neighbours. To investigate the role of chemodiversity in plant-aphid interactions, we used the Asteraceae Tanacetum vulgare, whose individuals differ pronouncedly in the composition of leaf terpenoids, forming distinct chemotypes. Plants were set up in a field consisting of plots containing five individuals of either the same or different chemotypes. Presence of winged aphids, indicating attraction, and abundance of winged and unwinged aphids, indicating fitness, were counted weekly on each plant. During the peak abundance of aphids, leaf samples were taken from all plants for re-analyses of the terpenoid composition and quantification of terpenoid chemodiversity, calculated on an individual plant (Shannon index, Hsind, also considered as α-chemodiversity) and plot level (Hsplot, = β-chemodiversity). Aphid attraction was neither influenced by chemotype nor plot-type. The real-time odour environment may be very complex in this setting, impeding clear preferences. In contrast, the abundance was affected by both chemotype and plot-type. On average, more Uroleucon tanaceti aphids were found on plants of two of the chemotypes growing in homogenous compared to heterogenous plots, supporting the associational resistance hypothesis. For Macrosiphoniella tanacetaria aphids, the probability of presence differed between plot-types on one chemotype. Terpenoid chemodiversity expressed as a gradient revealed negative Hsplot effects on U. tanaceti, but a positive correlation of Hsind with M. tanacetaria abundance. Aphids of M. fuscoviride were not affected by any level of chemodiversity. In conclusion, this study shows that not only the chemotype and chemodiversity of individual plants but also that of conspecific neighbours can influence certain plant-herbivore interactions. These effects are highly specific with regard to the plant chemotype and differ between aphid species and their morphs (winged vs. unwinged). Furthermore, our results highlight the importance of analysing chemodiversity at different levels.
N6-methyladenosine mRNA methylation is important for the light response in soybean
Authors: Zhang Liya , Zhang Yanyan , Liu Jun , Li Hongyu , Liu Bin , Zhao Tao
Published: April 2023

N6-methyladenosine (m6A) modification of messenger RNA (mRNA) is the most prevalent and abundant modification in eukaryotic mRNA and posttranscriptionally modulates the transcriptome at almost all stages of mRNA metabolism. In plants, m6A is crucial for embryonic-phase growth, flowering time control, microspore generation and fruit maturation. However, the role of m6A in plant responses to light, the most important environmental stimulus, remains unexplored. Here, we profile the m6A transcriptome of Williams 82, a soybean cultivar, and reveal that m6A is highly conserved and plays an important role in the response to light stimuli in soybean. Similar to the case in Arabidopsis, m6A in soybean is enriched not only around the stop codon and within the 3’UTR but also around the start codon. Moreover, genes with methylation occurring in the 3’UTR have higher expression levels and are more prone to alternative splicing. The core genes in the light signaling pathway, GmSPA1a, GmPRR5e and GmBIC2b, undergo changes in methylation modification and transcription levels in response to light. KEGG pathway analysis revealed that differentially expressed genes with differential m6A peaks were involved in the “photosynthesis” and “circadian rhythm” pathways. Our results highlight the important role played by epitranscriptomic mRNA methylation in the light response in soybean and provide a solid basis for determining the functional role of light on RNA m6A modification in this plant.
The role of linguistic and cognitive skills in reading Chinese as a second language: A path analysis modeling approach
Authors: Yang Lei , Xiong Ying , Chen Qi
Published: April 2023

This study examined the role of basic linguistic skills (vocabulary, syntax, orthography, and morphological awareness), basic cognitive skills (working memory), and higher-order cognitive skills (inference making and reading monitoring) in reading Chinese as a second language (L2). A total of 252 international students from Pakistan, Indonesia, Malaysia, and Laos were recruited, and a range of measures including a Chinese reading comprehension test (HSK level 3), four linguistic knowledge tests on Chinese lexical, syntactic, and orthographic knowledge as well as morphological awareness, a reading span test, an inference making task, and an inconsistency detection test. The results of hierarchical multiple regressions showed that the measured linguistic skills and cognitive skills explained 80% of the variances in L2 Chinese reading, among which morphological awareness made the largest contribution. The path analysis revealed that linguistic skills and working memory contributed indirectly to reading comprehensionviainference making and comprehension monitoring, while the two higher-order cognitive skills made direct contributions. Overall, this study demonstrates that inference making and comprehension monitoring contributed directly to reading comprehension, while linguistic skills and working memory functioned indirectlyviathe higher-order cognitive skills It also highlights the importance of morphological awareness in a hierarchical model of L2 Chinese reading.
Learning-based robotic grasping: A review
Authors: Xie Zhen , Liang Xinquan , Roberto Canale
Published: April 2023

As personalization technology increasingly orchestrates individualized shopping or marketing experiences in industries such as logistics, fast-moving consumer goods, and food delivery, these sectors require flexible solutions that can automate object grasping for unknown or unseen objects without much modification or downtime. Most solutions in the market are based on traditional object recognition and are, therefore, not suitable for grasping unknown objects with varying shapes and textures. Adequate learning policies enable robotic grasping to accommodate high-mix and low-volume manufacturing scenarios. In this paper, we review the recent development of learning-based robotic grasping techniques from a corpus of over 150 papers. In addition to addressing the current achievements from researchers all over the world, we also point out the gaps and challenges faced in AI-enabled grasping, which hinder robotization in the aforementioned industries. In addition to 3D object segmentation and learning-based grasping benchmarks, we have also performed a comprehensive market survey regarding tactile sensors and robot skin. Furthermore, we reviewed the latest literature on how sensor feedback can be trained by a learning model to provide valid inputs for grasping stability. Finally, learning-based soft gripping is evaluated as soft grippers can accommodate objects of various sizes and shapes and can even handle fragile objects. In general, robotic grasping can achieve higher flexibility and adaptability, when equipped with learning algorithms.
Innovations and trends in the coconut agroindustry supply chain: A technological surveillance and foresight analysis
Authors: Grass Ramírez José Fernando , Muñoz Ricardo Camacho , Zartha Sossa Jhon Wilder
Published: April 2023

Coconut (Cocos nucifera) is a raw material that has gained particular relevance for agribusiness in recent years. This has come about largely owing to the paradigm shift regarding its genuine nutritional benefits. It is especially due to innovation that has been incorporated into agro-industrial processing and the development of new products, and the fruits of such labor can be seen in the growing demand by consumers around the world. Integrally making full use of coconut, it turns out, is extremely important for agribusiness. Coconut indeed has become a benchmark, not only from the environmental dimension but also from the social and economic perspectives both of the communities that plant it and the agribusinesses that transform it. This study aims to identify technologies, new uses, trends, and innovations related to the coconut agro-industrial chain, as well as their prioritization, by means of a prospective study, using the Delphi method in two rounds. Two methods applied at the methodological level comprised a technological surveillance study by means of a literature review in a SCOPUS database, PatentsInspiration, complemented with commercial surveillance for the four major topics of plastic wood, coconut oil extraction, high salinity and moisture, and small-scale coconut by-products. Moreover, the Delphi method was used, in two rounds, with 178 topics, technologies, and innovations, classified into seven thematic groups. The Delphi was answered by 32 experts in the two rounds. Vantage Point text mining software was also applied for the analysis of the surveillance results. Within the seven thematic groups, the following 10 priority technologies are highlighted: functional phytochemicals, non-caloric sweeteners, coconut milk preservation technologies, water activity and shelf life, coconut sugar extraction methods, batch and continuous drying technologies, lyophilization, coconut fiber and shredded recycled PET, magnetic particle modification of activated carbon derived from coconut shell and biochar to effectively remove phenol from water, and biodegradable packaging for coconut derivatives. In addition, the following topics were prioritized in the sustainability grouper: sustainable agriculture, bioeconomy, family agriculture, and circular economy.
Geopolitical risks for Egypt wheat supply and trade
Authors: Gebeltová Zdeňka , Hálová Pavlína , Malec Karel , Bartoňová Klára , Blažek Vojtěch , Maitah Mansoor , Koželský Robert , Phiri Joseph , Appiah-Kubi Seth Nana Kwame , Tomšík Karel , Severová Lucie , Marušiak Jiŕí
Published: April 2023

Introduction

Since 2005, Russia has established a stable position in Egypt's wheat imports, and after 2016, it became the largest global wheat exporter. The shift in Russian grain production has visibly affected wheat export destinations in favor of developing countries. This paper identifies the main determinants of wheat trade in Egypt concerning the primary risks associated with the war in Ukraine.

Methods

The paper utilizes time series analysis, index analysis, and an econometric model to define the statistical relationship between the quantity of wheat imported into Egypt and population development, wheat price, and wheat production.

Results

Despite increasing wheat production growth rates (1.9% p.a. over 2000–2020) and a growing population (2.01% p.a.), Egypt is unable to reduce its import dependence below 50% of total consumption. Undernourishment in Egypt remains at 5.2%–5.4% of the population. The econometric model shows that variables describing the evolution of production, population, and prices are statistically significant in relation to wheat imports. Egypt's wheat imports continue to increase even with rising prices, which is typical for developing countries. The war in Ukraine and associated commodity price increases have far-reaching implications for Africa's food security and supply systems.

Discussion

Egypt's vulnerability to external influences, such as climate change, migration, rising commodity prices, and population growth, exacerbates the situation. Most African countries, including Egypt, struggle with the economic and social impacts of the COVID-19 pandemic. They also face rising food and energy prices, conflicts between the world's largest food producers, and increasing poverty rates. The research findings confirm that Egypt is among the highly vulnerable countries due to the war in Ukraine and the disruption of agricultural supply chains.
Non-Reciprocal MEMS Periodic Structure
Authors: Marconi Jacopo , Enrico Quadrelli Davide , Braghin Francesco
Published: April 2023

In recent years, active periodic structures with in-time modulated parameters have drawn ever-increasing attention due to their peculiar (and sometimes exotic) wave propagation properties. Although many experimental works have shown the efficacy of time-modulation strategies, the benchmarks proposed until now have been mostly proof-of-concept demonstrators, with little attention to the feasibility of the solution for practical purposes. In this work, we propose a micro electro-mechanical system (MEMS) periodic structure with modulated electromechanical stiffness featuring non-reciprocal band-gaps that are frequency bands where elastic waves are allowed to travel only in one direction. To this aim, we derive a simplified analytical lumped-parameter model, which is then verified through numerical simulations of both the lumped-parameter system and the high-fidelity multiphysics finite element model including electrostatic effects. We envision that this system, which can easily be manufactured through standard MEMS production processes, may be used as a directional filter in MEMS devices such as insulators and circulators.
Research on the Infrared Radiation Suppression of the High-Temperature Components of the Helicopter with an Integrated Infrared Suppressor
Authors: Yang Zongyao , Zhang Jingzhou , Shan Yong
Published: April 2023

The integrated infrared suppressor can reduce the infrared radiation signal of a helicopter and is compatible with radar-acoustic stealth. However, the issues that are caused by the integrated infrared suppressor, such as temperature increases on the rear fuselage surface and a lack of shielding at the exhaust port, need to be addressed, in order to further improve the infrared stealth capability of the helicopter. Aiming at this, the effects of the ambient temperature, fuselage surface emissivity, mixing duct shielding, and exhaust port shielding on the infrared radiation characteristics of the helicopter are studied with numerical simulation. The results show that the infrared radiation intensity of the helicopter, in 3–5 μm band and 8–14 μm band, decreases by about 20% and 10%, respectively, for every 6 K reduction in the ambient temperature. As the emissivity of the rear fuselage surface reduces from 0.8 to 0.5, the helicopter’s infrared radiation intensity, in a 3–5 μm band and a 8–14 μm band, decreases by about 6% and by about 4% and 1.3%, respectively, after the mixing duct is equipped with a shielding sheath. Installing deflectors at the exhaust port of the fuselage can prevent the detection rays from detecting the high-temperature components inside the fuselage, and when the emissivity of the deflectors is reduced from 0.8 to less than 0.5, or the deflectors are cooled by more than 80 K, they begin to play a role in suppressing the infrared radiation at the bottom of the helicopter.
Effect of Wavy Leading Edges on Airfoil Trailing-Edge Bluntness Noise
Authors: Xing Yudi , Chen Weijie , Wang Xingyu , Tong Fan , Qiao Weiyang
Published: April 2023

Among the several noise-generation mechanisms of airfoil self-noise, trailing-edge bluntness noise is an important noise source, which is caused by the vortex shedding at blunt trailing edges. A numerical study on airfoil trailing-edge bluntness noise control using the bio-inspired wavy leading edges is presented in this paper. The high-fidelity, improved, delayed, detached eddy simulation (IDDES) method was used to calculate the flow field, and the acoustic analogy method was used for noise prediction. For both the blunt-trailing-edge airfoils, a baseline airfoil with a straight leading edge and a bio-inspired airfoil with a wavy leading edge were used in this study. The chord-based Reynolds number was 400,000, and there was no angle of attack. The numerical results show that the trailing-edge bluntness noise of the baseline airfoil was significantly reduced by the wavy leading edges. The sound pressure level reduction was about 3.7 dB at the characteristic frequency, and the maximum sound pressure level reduction was as high as 35 dB. The trailing-edge bluntness noise was decreased at all directional angles. The maximum overall sound pressure level reduction was 6.3 dB at 0°. In addition, by analyzing the pressure fluctuations, wake characteristics, turbulent vortex structures and spanwise correlation and coherence of the flow field, the noise-reduction mechanisms of the bio-inspired airfoil are deeply revealed.
Aeroengine Diagnosis Using a New Robust Gradient-like Methodology
Authors: Rodrigo Jose , Sanchez de Leon Luis , Montañes Jose L. , Vega Jose M.
Published: April 2023

A new gradient-like methodology has been developed for aeroengine diagnosis, determining the engine health condition, which is defined by the engine degradation from an undegraded state and uses measurements at various sensors distributed along the engine. The developed tools are able to accurately compute, not only the engine degradation, but also the turbine inlet temperature, which is very important and novel in the field. The quality of a given sensors set is evaluated, and a method is developed to guide in the improvement of deficient sensors sets. The methodology is tested in a representative two-spool turbofan engine, obtaining consistent results in a computationally inexpensive way. Moreover, results are robust in connection with the random noise added to the sensors data.
Effects of Changing Climate Extremes on Maize Grain Yield in Northeast China
Authors: Dong Meiqi , Zhao Jin , Li E , Liu Zhijuan , Guo Shibo , Zhang Zhentao , Cui Wenqian , Yang Xiaoguang
Published: April 2023

The increased frequency of climate extremes associated with ongoing climate change has the potential for significant impacts on maize grain yield in maize-producing regions worldwide. In this study, we used a modeling approach to investigate the effects of different types of climatic extremes on maize grain yield in Northeast China. We combined annual mean air temperature and accumulated precipitation data and divided the climate years into 9 categories, using the 10th and 90th percentiles as extreme thresholds. The climate data were represented by 1 normal climate type, 4 individual climate extremes, and 4 combined climate extremes. Changes in the frequencies of climate extremes and their impacts on maize grain yields were analyzed for two 30-year periods (period I: 1960–1989; period II: 1990–2019) using the Agricultural Production Systems sIMulator (APSIM-Maize). Compared with period I, the occurrences of the normal climate and all 3 cold-related climate extremes (i.e., cold-normal, cold-humid, and cold-dry) decreased during period II, while occurrences of the other climate extremes increased. Moreover, according to the APSIM-Maize model, the estimated yield in the years with a normal climate decreased by 4.01%; the 3 cold-related climate extremes increased yields by 26.56%, 12.10%, and 6.68%, respectively; the 2 warm-related climate extremes (warm-normal and warm-dry) and normal-humid years decreased estimated yields by 6.39%, 24.12%, and 5.10%, respectively. The increase in the occurrence of warm-humid years increased the estimated yield by 11.69%. This work confirms the adverse effects of warmer temperatures in the absence of excess rainfall on grain yield and highlights the importance of extremely dry or wet conditions under normal temperature conditions.
Occurrence of Aeromonas Species in the Cutaneous Mucus of Barbour’s Seahorses (Hippocampus barbouri) as Revealed by High-Throughput Sequencing
Authors: Ortega Rose Chinly Mae H. , Tabugo Sharon Rose M. , Martinez Joey Genevieve T. , Padasas Chinee S. , Balcázar José L.
Published: April 2023

Although several studies have described the bacterial community composition associated with marine fish, there is limited information related to seahorses. Moreover, previous studies have demonstrated that the skin microbiota is useful for determining health status and common disorders in the host. This study, therefore, aimed to explore the skin bacterial community composition in Barbour’s seahorse (Hippocampus barbouri) using high-throughput sequencing of 16S ribosomal RNA genes. Water and sediment samples from the surrounding environment were also analyzed for comparative purposes. The results revealed that sequences affiliated with the Shewanellaceae family were dominant in the skin of female Barbour’s seahorses and sediment samples, whereas sequences affiliated with the Bacillaceae family were dominant in the skin of male Barbour’s seahorses. Interestingly, sequences affiliated with the Aeromonas genus were found in the skin of Barbour’s seahorses, whose abundance was slightly similar between the female and male specimens. Further comparative analysis showed that the presence of Aeromonas species in the skin of Barbour’s seahorses was strongly influenced by the surrounding sediment. Given that some Aeromonas species are known to be important pathogens in humans and fish, these results may be used for further research on the dependency of the skin microbial composition on the environment as well as determine whether the presence of Aeromonas and other detected species has implications on seahorse health.
The Origin and Invasion Pathway of Brown Rats Rattus norvegicus on Dok-Do Island Revealed by Genome-Wide Markers from 3-RADseq Approach
Authors: Kim Han-Na , Lee Ohsun , Lee Hwa-Jin , Kim Gyu-Cheol , Kim Hyeon-Soo , Derbridge Jonathan James , Jo Yeong-Seok
Published: April 2023

Biological invasions are known to cause local extinctions on islands. Dok-do, a small, remote volcanic island in the East Sea of Korea in the western Pacific, has recently been invaded by rats, posing ecological problems. To infer their origin and invasion pathway, we collected rats from Dok-do and from the potential introduction source locations, Ulleung-do in the Pacific Ocean, and four east coastal ports. First, we identified that the brown rat (Rattus norvegicus) was the only rat species occurring at collecting sites based on the key morphological characteristics. To determine the population-level genetic diversity pattern, we applied the 3-RADseq approach. After a series of filtrations (minor allele frequency < 0.05, Hardy–Weinberg equilibrium p < 1 × 10−7), 4042 SNPs were retained for the final dataset from the 25,439 SNPs initially isolated. The spatial structure and genetic diversity pattern of brown rats suggested that the rat population on Dok-do was likely introduced from Ulleung-do. Our work provides practical information that will assist in the management of invasive brown rats in vulnerable island ecosystems.
Effect of Corn Origin on Broiler Performance, Processing Yield, and Nutrient Digestibility from 1 to 35 Days of Age
Authors: Vargas Jose I. , Gulizia Joseph P. , Bonilla Susan M. , Sasia Santiago , Pacheco Wilmer J.
Published: April 2023

This experiment studied the effect of feeding corn from the United States (USA), Argentina (ARG), and Brazil (BRA) on broiler performance, processing yield, and nutrient digestibility from 1 to 35 d of age. A total of 900-day old YPM × Ross 708 male broilers were randomly sorted in 36 floor pens, each containing 25 chicks and subjected to three experimental diets, resulting in 12 replications per dietary treatment. Starter, grower, and finisher diets were formulated to be only different in corn origin. Data were analyzed as a one-way ANOVA and means were separated using Tukey’s HSD test, with statistical significance considered at p ≤ 0.05. No significant differences (p > 0.05) were found in body weight, body weight gain, and feed intake from 1 to 35 d of age among the treatments. However, broilers fed diets with the inclusion of corn from the USA and BRA had a lower feed conversion ratio (FCR) compared with broilers fed diets with corn from ARG from to 1 to 35 d of age (1.434 and 1.434 vs. 1.452 g:g; p = 0.002). Broilers fed diets with the inclusion of corn from BRA had a higher breast weight compared with broilers fed diets with the inclusion of corn from ARG (575 vs. 553 g; p = 0.036), but did not differ in breast weight of broilers fed diets with corn from the USA (575 vs. 556 g; p > 0.05). Corn origin did not influence (p > 0.05) crude protein and fat digestibility. However, broilers fed diets with corn from the USA and BRA had greater phosphorus (P) (63.37, 62.23 vs. 55.26%; p = 0.0003), calcium (Ca) (41.59, 43.85 vs. 30.23%; p = 0.0003), and potassium (K) (88.98, 87.97 vs. 86.04%; p = 0.001) digestibility compared with broilers fed diets with corn from ARG. Overall, corn origin influenced FCR, breast weight, and P, Ca, and K digestibility of broilers from 1 to 35 d of age.
Extracellular Vesicles of Pseudomonas: Friends and Foes
Authors: Henriquez Tania , Falciani Chiara
Published: April 2023

Extracellular vesicles (Evs) are small spherical vesicles capable of transporting molecules (such as proteins, nucleic acids and lipids) from one cell to another. They have been implicated in processes such as cell-to-cell communication, pathogenicity, biofilm formation and metabolism. In parallel, Evs have been proposed as interesting biotechnological tools. In recent years, antibiotic resistance has become a major problem for human health worldwide. A pathogen singled out as among the most lethal antibiotic-resistant organisms is Pseudomonas aeruginosa, an important Gram-negative bacterium that has been extensively studied for the production and characterization of Evs. Here, we describe the advances made in the last decade regarding understanding of the role of Evs in the pathogenicity of Pseudomonas. We also examine the potential of Evs for the development of new treatment strategies.
Adherence to 2015 ESC Guidelines for the Treatment of Infective Endocarditis: A Retrospective Multicentre Study (LEIOT Study)
Authors: Pallotto Carlo , Bolla Cesare , Penpa Serena , Genga Giovanni , Sarda Cristina , Svizzeretto Elisabetta , Tommasi Andrea , Stolaj Elisa , Salvaderi Andrea , Piceni Giorgia , Maconi Antonio , Chichino Guido , Francisci Daniela ,   on behalf of the LEIOT Study Group
Published: April 2023

Background: Infective endocarditis (IE) is still a severe disease with elevated morbidity and mortality. Nevertheless, the last European guidelines (GL) date back to 2015, and a recent survey described a diffuse suboptimal adherence to their recommendations. Here, we described a real-life scenario about adherence to IE treatment GL. Methods: This was a retrospective, multicentric, case–control study. All the cases of IE admitted to our wards from 2016 to 2020 were enrolled. Patients were divided into two groups, according to the non-adherence (group A, cases) or adherence (group B, controls) to 2015 ESC guidelines. Only targeted treatments were considered. Groups were compared for demographic, clinical, microbiological, and laboratory data and outcome. As a post hoc analysis, we analysed the characteristics of deviations from the guidelines and how these deviations affected mortality. Results: A total of 246 patients were enrolled, with 128 (52%) in group A and 118 (48%) in group B. Groups were homogeneous except for aetiologies: staphylococcal and blood-culture-negative IE were more frequent in group A, while streptococcal and enterococcal IE were more frequent in group B (p < 0.001). In-hospital mortality was comparable in the two groups. The most frequent causes of deviations from the guidelines were use of daptomycin, in addition to standard treatments and the missing administration of rifampin or gentamycin. Conclusions: Adherence to 2015 ESC guidelines was limited but it did not affect mortality.