bluuebunny/crossref_metadata_2025 huggingface dataset:
Membangun Konsep Niat Berkunjung Kembali Ke Desa Wisata Di Kabupaten Buleleng Bali
Authors: Komang Ary Pratiwi  , I Made Sudarsana  , I Putu Mahendra Adi Wardana
Published: December 2024

Bali is part of Indonesia whose economy is dominated by the tourism sector, and tourist villages have become an alternative tourism which is a current trend and helps the recovery of the Balinese economy after the Covid pandemic. The aim of this research is to determine and explain the variables that influence the concept of intention to return to a tourist village, such as servicescape, destination image, customer satisfaction and local wisdom of Tri_Kaya_Parisudha. The research methodology used is descriptive statistical analysis and inferential statistical analysis, namely using SEM PLS. The sample for this research consisted of 190 respondents, using a sampling technique, namely purposive sampling. Thus, the results of this research findings are 8 hypotheses that are accepted and have a significant effect.
CUIDADOS PALIATIVOS: ANÁLISE SOB AS PERSPECTIVAS DO DIREITO SOCIAL À SAÚDE E DA DIGNIDADE DA PESSOA HUMANA
Authors: Vieira Silvia Maria Correa , Massaú Guilherme Camargo , Vieira Maíra
Published: December 2024

No Brasil, o direito à saúde tem previsão constitucional e universal. No entanto, a saúde ainda é abordada com foco no tratamento da doença, desprestigiando outros aspectos da saúde, tais como prevenção e, em especial os cuidados paliativos. O presente artigo tem como tema os cuidados paliativos como importante instrumento para efetivação do direito à saúde, sob uma perspectiva de respeito à dignidade da pessoa humana. O objetivo geral é abordar sobre os cuidados paliativos e sua importância para a dignidade da pessoa humana. O estudo visa trazer a questão do direito à saúde, nas suas dimensões de direito humano, direito fundamental e direitos social, assegurado a todos os cidadãos, bem como um dever do Estado. Nesse cenário, abordar-se-á os cuidados paliativos como importante prática de saúde que dá luz à dignidade da pessoa humana. A metodologia empregada é qualitativa, utilizando-se revisão bibliográfica e análise de dados.
ATIVISMO JUDICIAL, BACKLASH E MARCO TEMPORAL DE OCUPAÇÃO INDÍGENA NO BRASIL: RESISTÊNCIA E REPERCUSSÕES
Authors: Leal Rodrigo de Lima , Mallmann Jean , Santos Luiz Felipe Ferreira dos
Published: December 2024

O Brasil passa por um momento de tensões entre os Poderes Legislativo e Judiciário. A jovem democracia brasileira está sendo atingida por erosões, aptas a lhe causar recuos no regime político, conforme se denota a partir do estudo da Teoria do Pêndulo Democrático, de Arthur Schelesinger Jr. Grupos políticos e parte da sociedade têm criticado decisões judiciais, em especial as proferidas pelo Supremo Tribunal Federal, acusando a Corte de uma postura de excessivo ativismo judicial. Exemplo dessas manifestações sociais e institucionais podem ser percebidas em casos paradigmáticos, como ocorreu no leading case julgado no Recurso Extraordinário (RE) nº 1.017.365/SC, que estabeleceu a definição do estatuto jurídico-constitucional das relações de posse das áreas de tradicional ocupação indígena à luz das regras dispostas no artigo 231 do texto constitucional (Tema 1031), cuja decisão da Suprema Corte foi no sentido da inconstitucionalidade da tese do marco temporal sobre terras indígenas. O Poder Legislativo, em reação a essa decisão, aprovou a Lei nº 14.701 de 2023, que ficou conhecida como “Lei do Marco Temporal”, intensificando as tensões entre os poderes e enfraquecendo as instituições e a democracia.
SUSTENTABILIDADE ENERGÉTICA E PRODUÇÃO DE CRIPTOMOEDAS
Authors: Arrabal Alejandro Knaesel , Flores Ubirajara Martins , Serratine Davi Tiskoski
Published: December 2024

O trabalho aborda a questão da sustentabilidade energética caracterizada como um vetor de significativa relevância ambiental, frente aos potenciais impactos da produção de criptomoedas, atividade diretamente vinculada a massiva operação de computadores, configurações de hardware e métodos computacionais envolvidos. Procura-se descrever as implicações para o meio ambiente natural em decorrência do crescente mercado de criptoativos, além de apontar os projetos e iniciativas orientadas a prover condições para o desenvolvimento das chamadas tecnologias verdes. O trabalho revela o caráter ainda muito recente dos estudos e relatórios publicados sobre a relação entre produção de criptomoedas e potenciais impactos ambientais, o que compromete diagnósticos mais precisos para orientar a formulação de políticas públicas, adequadas as especificidades do setor. De todo modo, constata-se a existência de iniciativas por parte dos atores envolvidos, voltadas ao desenvolvimento e uso de tecnologias ambientalmente sustentáveis.
Дизайн роботизованого навчального робочого місця в офлайн-середовищі з Yaskawa robot
Authors:   Technical University of Košice, Kovaluk David , Semjon Jan ,   Technical University of Košice, Sabol Matus ,   Technical University of Košice, Hrabcak Matus ,   Technical University of Košice
Published: December 2024

The article deals with the creation of 3D models of individual parts of a robotic workplace in the Creo Parametric environment. The created models of the workplace components were subsequently imported into the MotoSim offline envi-ronment, where three variants of the assembly process were designed and simulated at the robotic workplace with the Yaskawa GP8 robot. The selected variant was then imported into a real workplace, where it was debugged and tested. The goal was to create an educational workplace where it would be possible to carry out teaching and training online or offline on a robot from Yaskawa.
Вибір між реляційними та нереляційними базами даних
Authors:   Український державний університет науки і технологій, Резніченко Олег , Ляшенко Оксана ,   Український державний університет науки і технологій, Архипова Вікторія ,   Український державний університет науки і технологій
Published: December 2024

Стаття є оглядово-інформаційною. У цьому дослідженні розглянуто основні характеристики сучасних моделей баз даних, що використовуються для зберігання та обробки інформації, яка може бути отримана в будь-якій галузі науки, суспільства та промисловості. Розглянуто ключові характеристики та особливості сховищ даних. Визначено, що існує дві основні моделі баз даних – реляційні та нереляційні. Сформульовано їхні недоліки та переваги, що обмежують або, навпаки, розширюють їхні функціональні можливості. Зроблено висновки щодо перспектив використання сховищ даних.
Геометричний синтез механізмів привода стола з поступальним рухом та проколювачів ниткошвейної машини
Authors:   Національний університет «Львівська політехніка», Книш Олег , Стрілецький Андрій ,   Національний університет «Львівська політехніка», Млинко Оксана ,   Національний університет «Львівська політехніка»
Published: December 2024

Важливою операцією при виготовленні книжкової продукції скріпленої нитками є шиття книжкових блоків. За результатами аналізу наукових праць, які присвячені дослідженню технологічного процесу шиття нитками книжко-вих блоків, окреслено шляхи удосконалення конструкції механізмів хитного стола та проколювачів ниткошвейної ма-шини. Запропоновано схему з поступальним столом та спрощений кулачково-важільний механізм привода проколювачів. Удосконалена циклограма роботи механізмів забезпечить зменшення вистою стола в зоні шиття. Проведений геометричний синтез механізмів поступального стола та проколювачів у відносних величинах уможливлює подаль-ший їхній кінематичний та силовий аналізи.
Математичне моделювання вібраційної площадки з регульованими за жорсткістю пружними опорами
Authors:   Національний університет «Полтавська політехніка імені Юрія Кондратюка», Орисенко Олександр , Шека Олександр ,   Національний університет «Полтавська політехніка імені Юрія Кондратюка»
Published: December 2024

У статті описано математичну модель вібраційної площадки для віброформування малогабаритних бетонних виробів, що пов’язує амплітуди просторових коливань робочого органа із її конструктивними та технологічними па-раметрами. Математична модель створена за допомогою узагальненого рівняння руху Лагранжа другого роду, при її розробленні використані методи фізико-математичного моделювання. Для опису просторового руху коливної маси віброплощадки було прийнято кілька гіпотез, які дозволили значно спростити математичні викладки без погіршення точності кінцевих результатів. Отримана математична модель у вигляді системи трьох диференціальних рівнянь другого порядку описує просторовий рух робочого органа вібраційної площадки із середовищем завантаження як рух абсолютно твердого тіла. На основі розрахованих числових значень коефіцієнтів жорсткостей і в’язкого опору для пружних віброізоляційних елементів, що задовольняють умові налагодження далеко зарезонансного режиму роботи віброплощадки, визначено амплітудні значення лінійних та кутових вібропереміщень робочого органа, побудовано амплітудно-частотні характеристики коливної системи та графіки часових залежностей руху коливної маси за від-повідними узагальненими координатами.
Прогнозування фізичних властивостей нанокомпозитів на основі поліетилену методами молекулярної динаміки
Authors:   Національний технічний університет України «Київський політехнічний інститут імені Ігоря Сікорського», Чолак Ірина
Published: December 2024

Виконано дослідження фізико-механічних властивостей нанокомпозитів поліетилен-графен залежно від температури та об’ємної частки наповнювача з використанням методів молекулярної динаміки. Для оперативного про-гнозування поведінки матеріалів отримано двопараметричні залежності фізико-механічних властивостей у діапазоні температур (280–320) К та об’ємної частки графену (0–1,5) %. Одержані дані дадуть змогу виконувати моделювання термо-пружно-пластичного стану виробів в умовах експлуатації в континуальному наближенні.
Comparison of the sexual behaviors and syndromic diagnosis between rural and urban cases in east-central India: A retrospective hospital-based study
Authors: Gupta Rakhee , Singh Suvesh
Published: December 2024

Objectives:

Sexually transmitted infections (STIs) are a significant public health challenge in India. Limited healthcare access, socioeconomic inequalities, and gender-based vulnerabilities contribute to the disproportionate burden in rural and urban areas. The aim of this study was to compare the sociodemographic profile, sexual behavior, and the syndromic diagnosis of STIs between rural and urban cases attending an STI clinic.

Materials and Methods:

A cross-sectional retrospective study was conducted at an STI clinic in east-central region of India. All patients, irrespective of age and sex, who visited the clinic from July 2022 to November 2023, were included in the study. Demographic, clinical, and behavioral data were compared between urban and rural cases using appropriate statistical methods.

Results:

Out of 925 patients, rural and urban cases were 70.8% and 29.2%, respectively. Rural cases: 92.2% females, 7.8% male; urban cases: 81.1% females, 18.9% males. The majority were aged 20 -40 years. There were more cases aged below 20 years from urban areas (6.3% vs. 2.7%; P < 0.01). Illiterate cases were more from rural area (P < 0.01); and those educated >10th grade from urban area (P < 0.01). The predominant occupation was homemakers and incomes ranged between Rs 5000 and 10000. In both rural and urban areas, lower abdomen pain was the most common symptom, followed by vaginal discharge. Genital herpes (P < 0.01) and syphilitic genital ulcers to syphilis (P = 0.01) were more common in urban areas compared to rural. Retroviral infection was reported to be similar from both areas.: Mean age of sexual debut was 19.5 years in rural and 20.2 year in cases from urban areas (P < 0.01). Time since last sexual encounter (21.2 vs. 20.3 days, P = 0.01), and cases with multiple partners (4.1% vs. 8.8%; P < 0.01) were different in cases from rural and urban cases. The difference in drug abuse and contact with sex worker were not significantly different between the groups.

Limitations:

Retrospective study design, hospital-based study setting and lack of microbiological confirmation were the limitations of this study.

Conclusion:

There were disparities in the sociodemographic profile, STI patterns, and sexual behavior between rural and urban cases of the east-central zone of India.
‘Making-as-a-sense-of-being’ in Art Education for an Ecological Turn A Philosophical Exploration of Tim Ingold's concept of ‘Making’
Authors:   Society for Art Education of Korea, SEO Jeongeun
Published: December 2024

This study explores the concept of "making" in art from a philosophical perspective, elucidating how art functions as a mode of activity for perceiving the presence of the Other and corresponding to it. It further proposes that this understanding of art can serve as a foundational principle for education that facilitates an ecological trun, not as an epistemological or curricular issue, but as a question concerning our ways of being. Drawing on Tim Ingold’s concept of “making,” the study reformulates the traditional notion of making in art—commonly reduced to a modernist sense of making—into “making-as- a-sense-of-being.” This expanded concept highlights art’s uniqueness and its potential for fostering ecological awareness. The findings position art education as: (1) a process of practicing “material thinking,” (2) an engagement in “doing-in-undergoing” within relational situations, and (3) an activity of “imprinting” rather than “expressing.” These insights reimagine art education as a practice of opening ourselves to the Other, dissolving rigid boundaries of the self, and rehearsing relational modes of existence, thereby contributing to ecological transformation.
Unleashing Antibacterial Potential of Clove and Cinnamon by in vitro and in silico analysis for Safer Sanitization
Authors: Shedge Vaishnavi , Kotharkar Nandini , Sambrani Seema
Published: December 2024

The proliferation of infections can be overcome by the application of germicidal products like sanitizers and disinfectants. However, conventional sanitizers often contain hazardous chemicals, posing risks to human health and the environment while also fostering resistance. Plants, with their bioactive compounds, offer a greener alternative to chemical-laden products. This research aimed to explore the antimicrobial potential of plant matrices by in vitro and in silico analysis for integration into germicidal products. Clove and cinnamon samples were extracted by the Soxhlet extraction and later antibacterial activity was assessed by well diffusion assays and MIC tests. GC-MS analysis identified the bioactive compounds while in silico analysis was employed to evaluate their ability to bind and inhibit target bacterial proteins. Clove and cinnamon extracts displayed promising antibacterial properties.

Among the identified bioactive compounds, caryophyllene oxide from clove and gamma-sitosterol from cinnamon exhibited the strongest negative binding energies against target proteins. Caryophyllene oxide achieved a docking score of -8.9 kcal/mol against S. aureus protein while gamma-sitosterol scored -8.8 kcal/mol against S.pyogenes protein. Both in vitro and in silico findings confirm the significant antimicrobial activity of clove and cinnamon extracts due to their bioactive compounds. Consequently, these extracts hold promise for inclusion in germicidal products.
Assessment of the level of influence of oil exporting countries’ organizations on the world oil market
Authors: Laznik A. A. , Gordeeva T. S.
Published: December 2024

Oil is one of the signiﬁcant energy resources for the majority of the world’s states, so many of them monitor and analyze the price of black gold. Currently, there are such organizations of oil exporting countries as OPEC and OPEC+, which for a long time continue to inﬂuence not only the world market of this energy resource but also the events taking place in the economic and political spheres of the world. These organizations’ actions have a direct impact on market conditions, policy making, oil price, and the volume of its supply on the market in world trade. The collective responsibility of the member countries for a signiﬁcant portion of global oil production makes the decisions and actions of OPEC and OPEC+ extremely important for the global oil industry and the economy as a whole. All the above-mentioned points to the relevance of the topic of the study, the objectives of which are to analyze the history of the emergence of the oil exporting countries’ organizations, the dynamics of their development during the history of their existence, as well as to assess the degree of their inﬂuence on the oil industry and the global economy as a whole.
Application of the customs procedure of processing in the customs territory when performing foreign trade operations
Authors: Lysenko E. A. , Fomin S. V.
Published: December 2024

The relevance of the research topic lies in the fact that the customs procedure of processing in the customs territory, which allows the use of imported goods in products manufacture for export without paying customs duties and taxes, becomes the object of close attention of foreign economic activity participants, causing both a high level of interest from the economic point of view and certain difﬁculties associated with its application in foreign trade. The purpose of the study is to conduct an economic and statistical analysis of the application of the customs procedure of processing in the customs territory and to propose ways to improve it. The tasks to achieve the goal were: analyzing the theoretical and legal foundations of the customs procedure application, analyzing its application, identifying the customs control stages over its application, identifying problematic aspects in its use, and proposing ways to solve them. When performing the tasks, the following general scientiﬁc methods were used: observation, induction and deduction, and collection and analysis of statistical data. As the study result, conclusions have been formulated based on the results of economic and statistical analysis of the application of the customs procedure of processing in the customs territory, the customs control stages over its application have been identiﬁed, the directions in which problems arise in the procedure application have been revealed, and proposals for their solution have been developed.
Energy crisis of 2021–2022 as a harbinger of a change in the global energy system
Authors: Rechkina E. A. , Terekhov A. M.
Published: December 2024

The energy mode concept, has been characterized. Energy patterns types, history of their formation and development have been summarized. The prerequisites for forming a new energy mode based on the increasing share of renewable energy sources and hydrogen raw materials in the energy production structure have been highlighted. The change of the energy structure will take place in the coming decades. The following scientiﬁc methods of research were used in the paper: literature analysis and analysis of statistical data. Data for the period from 1965 to 2022 were used. The purpose of the study is to identify the role of the energy crisis of 2021–2022 as a factor contributing to a new energy structure formation that will be implemented in the coming decades. The subject of the study is to analyze and evaluate the change of the energy pattern in the international energy market, and the object of the study is the world energy market.
Advantages and disadvantages of working at university: estimates of scientific and pedagogical employees
Authors: Efimova G. Z.
Published: December 2024

In the article the focus of the research interest is directed to the advantages and limitations of work at university as assessed by scientiﬁc and pedagogical employees. The empirical study was conducted using the semi-structured interview method with 145 scientiﬁc and pedagogical employees from 7 leading Russian universities. The classiﬁcation of strengths (advantages) and weaknesses (disadvantages) of working at university has been formed, which are combined on the following grounds: organizational and managerial, social and academic, ﬁnancial and economic, and territorial and infrastructural. Advantages of working at university: favorable conditions for academic development; stable team of professionals and comfortable working atmosphere; lack of inertia and routine of the labor process; developed material and technical base and formed infrastructure of university; job stability and social guarantees. Disadvantages of working at university: high workload, which leads to emotional overwork and lower quality of work; bureaucratic procedures distract from the main work; lack of desired support from the management. Comprehensive work of university management, aimed at the systemic development of personnel policy, will eliminate the above- mentioned shortcomings and ensure the reduction of their occurrence risk. The obtained results of the sociological research can be used in practical work and in justiﬁcation of managerial decision-making by top management in universities, can be useful to other stakeholders such as scientiﬁc and pedagogical employees, graduate students, and young people oriented to employment in higher education institutions and building an academic career.
Justice sensitivity of youth with different levels of income as an actual socio-psychological problem
Authors: Dementiev A. S. , Tsvetkova N. A.
Published: December 2024

The article substantiates the relevance of studying the socio-psychological determinants of sensitivity to justice in Russian youth with different levels of wealth. The sensitivity to justice concept itself has been revealed, its structure presented and its evolution shown; the wealth concept has been given. Four roles that a person can occupy in situations subjectively perceived as unfair (a ‘victim’ – the injustice is committed towards them; a ‘witness’ – they observe injustice towards another people; a ‘beneﬁciary’ – a person beneﬁts from the situation of injustice towards another one; a ‘violator’ – they act unfairly) have been characterized. A review of domestic and foreign studies of the relationship among sensitivity to justice and other personality characteristics, carried out over the past ﬁve years on various samples, has been given. Prospects for research into various aspects of this scientiﬁc problem, including cross-cultural differences, have been shown. Sensitivity to justice in modern social psychology is characterized as a relatively independent personality trait, but its socio-psychological determination is poorly studied. The model of empirical research of socio-psychological determinants of sensitivity to justice in youth with different levels of wealth has been presented.
Subject Olympiads as an effective tool of management personnel training in universities in modern conditions
Authors: Zakharova I. O. , Orlova S. N.
Published: December 2024

The present article studies the issue of using subject Olympiads in higher education institutions for effective training of managerial personnel on the example of the intra-university Olympiad in English language, held in November 2023 at the State University of Management. The quantitative and qualitative composition of participants by training areas and educational programs has been studied, sociological and didactic and methodological aspects of the Olympiad have been highlighted, individual tasks descriptions have been given, demonstrating their high practice-orientedness and relevance. The article concludes that participation in subject university Olympiads stimulates the interest of students of management specialties to the subject of study and increases their competence level. The competitive nature of the Olympiads contributes to a more successful subsequent adaptation of students to a highly competitive professional environment, creating conditions of healthy competition. Conducting subject competitions in universities solves the problems facing the system of higher education in terms of forming a creative educational environment that meets the challenges of the time, and training management specialists capable of effectively solving professional problems against the background of constantly changing economic and political situation in a tough external and internal environment.
Socially-determined factors of positive transformation of the professional and labor self-concept of persons with musculosketal disorders
Authors: Istomina E. V.
Published: December 2024

The article studies social factors that determine the features of transformation of professional-labor self-concept in students with musculoskeletal disabilities studying under inclusive conditions in organizations of secondary vocational and higher education. The study was carried out on a sample of 106 students with musculoskeletal disorders of ﬁnal years of educational organizations, in whom positive, negative, and neutral forms of transformation were recorded during the study. It has been revealed that in the group of students characterized by positive changes in professional and personal development during education and professional training, the transition of maladaptive forms of professional and labor self-concept into adaptive ones that allow them to achieve success in professional development, the majority of them are those who have an extensive network of social contacts, including friends with disabilities, classmates, and other people without any disabilities, teachers, and professors who give them the opportunity to develop their professional self-concept. In this group, most students have high rates of satisfaction of basic psychological needs for autonomy, social contacts, and competence, whereas in the group of students characterized by negative transformation of professional and labor self-concept, many identify themselves only with the social group of disabled people, feel alienated from the outside world with excessively high rates of satisfaction of basic psychological needs, which demonstrates their helplessness and deprivation of conditions of their professional and personal development.
Increasing digital maturity in innovative development management in a company
Authors: Sviridova S. V. , Horoshilov D. N.
Published: December 2024

Digital maturity level determines the ability of an enterprise to quickly and effectively implement digital management tools, including in innovative activities. Increasing digital maturity is becoming a necessary task for innovative and active enterprises aimed at increasing business sustainability. Studying theoretical and methodological aspects of enterprises’ digital maturity allowed us to identify a range of current issues. Theoretical substantiation of the concept and content of an enterprise’s digital maturity has been carried out, and its key characteristics have been formed. Digital maturity assessment stages and tasks of increasing digital maturity in managing an enterprise’s innovative development have been highlighted. Methodological approaches digital maturity assessment has made it possible to form an authors’ way of organizing and managing digital maturity level. The authors recommend to create a working group and a Coordinating council for managing an enterprise’s digital maturity. The functional content of the activities of the council and its specialists at different levels has been proposed. To solve the problem of determining the time spent on managing and monitoring digital maturity, a mathematical model for time redistribution for operations has been developed. The optimization of operations complexity redistribution in monitoring an enterprise’s digital maturity has been carried out. The article concludes that effective organizational and technological management of an enterprise will open up the possibility of increasing its digital maturity level.
Methodological basis for identifying promising industries of business specialization in Russian regions while developing digital technologies
Authors: Ivanov S. L.
Published: December 2024

A methodological approach has been developed to identify promising sectors of business specialization in the Russian regions in order to develop speciﬁc types of digital technologies in them. The approach implementation has been evaluated in several stages. At the ﬁrst stage, the leading regions have been identiﬁed in terms of growth rates of indicators characterizing the use of digital technologies in organizations for the period from 2020 to 2022. At the second stage, business specialization industries groups have been revealed in which the digital technologies development is the highest priority. It became possible thanks to the identiﬁcation of “transition” groups of industries by the level of digitalization. The leading regions in terms of the use of digital technologies in organizations depending on the growth rate of the level of their dissemination have been identiﬁed. Priority sectors of business specialization have been revealed by the share of organizations using digital technologies. In particular, it has been found that wholesale and retail trade, as well as the information technology industry have the potential for the spread of technologies for collecting, processing, and analyzing big data. The manufacturing industry, wholesale and retail trade, and information technologies have the potential to spread digital platforms.
Eﬀective commercial activity of a company factors in digital economy
Authors: Vandysheva S. V. , Boykova A. L.
Published: December 2024

In modern world, digital economy affects all aspects of commercial activity, and successful application of digital innovations is becoming a key factor in companies’ competitiveness. Commercial organizations in their activities use software tools and the Internet, which signiﬁcantly expands their opportunities for successful development. The key factors of effective commercial activity in the context of the rapid development of digital economy have been highlighted. Referring to the statistical data of the Federal State Statistics Service, the authors analyzed the trends in information technologies implementation in Russian economy. Special attention has been paid to reviewing the main difﬁculties that Russian companies face when trying to integrate modern digital solutions into their operations. Recommendations have been given on digitalization of key components of commercial activities, including customer services automation, e-commerce, digital supply chain management, big data analytics to optimize business strategies, and online marketing. The study is supported by the examples of speciﬁc tools and techniques that have already shown their effectiveness in practice for Russian companies adapting to digital economy. The research is based on the system and process approaches.
Capturing and labeling CO2 in a jar: Mechanochemical 17O-Enrichment and ssNMR study of Sodium and Potassium (bi)carbonate Salts
Authors: Peach Austin , Fabregue Nicolas , Erre Celia , Métro Thomas-Xavier , Gajan David , Mentink-Vigier Frédéric , Scott Faith , Trébosc Julien , Voron Florian , Patris Nicolas , Gervais Christel , Laurencin Danielle
Published: December 2024

With the rapid increase in temperatures around the planet, the need to develop efficient means to reduce CO2 emissions has become one of the greatest challenges of the scientific community. Many different strategies are being studied worldwide, one of which consists in trapping the gas into porous materials, either for its short- or long-term capture and storage, or its re-use for the production of value-added compounds. Yet, to further the development of such systems, there is a real need to fully understand their structure and properties, including at the molecular-level following the physisorption and/or chemisorption of CO2 (which can lead to various species, including carbonate and bicarbonate ions). In this context, 17O NMR naturally appears as the analytical tool of choice, because of its exquisite sensitivity to probe subtle differences in oxygen bonding environments. To date, it has scarcely been used, due to the very low natural abundance of 17O (0.04%), and the absence of commercially available 17O-labeled compounds adapted to such investigations (e.g., 17O-CO2(g), or 17O-enriched Na- and K- (bi)carbonate salts, which can be readily transformed into CO2). Herein, we demonstrate how, using mechanochemistry, it is possible to enrich with 17O a variety of Na- and K- (bi)carbonate salts in a fast, economical, scalable, and user-friendly way. The high enrichment levels enabled recording the first high-resolution 17O ssNMR spectra of these phases at different temperatures and magnetic fields. From these, the typical spectral signatures of (bi)carbonate ions could be obtained, showing their strong sensitivity to local dynamics. Lastly, we show how thanks to the selective 17O-labeling, singular aspects of the reactivity of carbonates in materials can be unveiled using in-situ 17O ssNMR. In the long run, it is expected that this work will open the way to more profound investigations of the structure and properties of carbon capture and storage systems, and, more generally speaking, of functional materials containing carbonates.
A Self-Driving Lab for Nano- and Advanced Materials Synthesis
Authors: Zaki Mohammad , Prinz Carsten , Ruehle Bastian
Published: December 2024

The recent emergence of self-driving labs (SDL) and material acceleration platforms (MAPs) demonstrates the ability of these systems to change the way chemistry and material syntheses will be performed in the future. Especially in conjunction with nano and advanced materials which are generally recognized for their great potential in solving current material science challenges, such systems can make disrupting contributions. Here, we describe in detail MINERVA - an SDL specifically built and designed for the synthesis, purification, and in line characterization of nano and advanced materials. By fully automating these three process steps for seven different materials from five representative, completely different classes of nano and advanced materials (metal, metal oxide, silica, metal organic framework, and core-shell particles) that follow different reaction mechanisms, we demonstrate the great versatility and flexibility of the platform. We further study the reproducibility and particle size distributions of these seven representative materials in depth and show the excellent performance of the platform when synthesizing these material classes. Lastly, we discuss the design considerations as well as the hardware and software components that went into building the platform and make all components publicly available.
Surfactant-free colloidal gold nanoparticles: room temperature synthesis, size control and opportunities for catalysis
Authors: Panagopoulos Dionysis , Alamdari Armin Asghari , Quinson Jonathan
Published: December 2024

Nanomaterials are at the forefront to develop and improve several technologies spanning from catalysis to medicine and sensing. Simple(r) preparation methods of nanomaterials can greatly benefit to fundamental studies and facilitate the development of nanomaterials towards real-life applications. Here, an easily implementable surfactant-free colloidal synthesis, simply achieved in alkaline mixtures of water and mono-alcohol (e.g. ethanol), performed at room temperature in the case of gold nanoparticles, and compatible with the principles of Green Chemistry, is exploited and further developed to easily perform size-effects studies at the nanoscale. Gold nanoparticles in the size range of 5 to 22 nm are easily prepared from a solution of 0.5 mM HAuCl4, 2 mM NaOH and 20 v.% ethanol or methanol, by initiating the synthesis in different simple ways: sonochemistry, stirring, manual shaking, using different grades of precursors, using different solvents. The nanomaterials are shown to be suitable model systems to study size effects at the nanoscale, with the example of alcohol electrocatalytic oxidations performed in alkaline media.
Lithium Zincate-Enabled Divergent Synthesis: Regioselective One-Pot Formation of Heteroaryl Compounds
Authors: Pierret Alexandre , Magra Kevin , Lopez Hugo , Kauffmann Thomas , Denhez Clément , Abdellah Ibrahim , Werlé Christophe , Vasseur Alexandre
Published: December 2024

We present a lithium zincate-enabled, divergent one-pot synthesis for regioselective C–C bond formation in heteroaryl compounds. By modifying the zinc coordination environment, a single set of reagents (ZnCl₂, organolithium R1Li, and diethyl (5-halo)thenylphosphate) was found to generate two distinct products through either a consecutive reaction sequence or two-independent intermolecular steps. This approach extends the versatility of lithium organozincates to regioselective CAr(sp2)-Cthienyl(sp2) and Cthenyl(sp3)-CAr(sp2) couplings without requiring transition metals and/or arenes pre-activated with a boronic acid moeity. With a broad substrate scope and reliance on zinc and lithium—abundant, non-toxic metals—this approach offers a sustainable route to complex molecules with relevance for pharmaceuticals and materials science.
Effect of tertiary amine selection on CO2 to formic acid hydrogenation with Au-np catalyst
Authors: de Leeuw den Bouter Anouk W.N. , Meijer Luca M.P. , Brito Larissa , Miquelot Adeline , Olivier Pierre , van der Schaaf John
Published: December 2024

The influence of the tertiary amine on CO2 conversion and product selectivity for the direct hydrogenation of CO2 towards formic acid is experimentally studied in batch and packed bed reactors using a Au/TiO2 catalyst. A wide range of tertiary amines were selected, based on their boiling point, kinetic diameter, pKa and solubility with alcohol-based solvents and formic acid. Following these criteria, 15 amines were selected having a wide range of pKa values and molecule sizes. To allow for an initial screening of kinetic rates, formic acid decomposition reactions were performed in batch reactors using an Au/TiO2 catalyst. Following the selection of the most promising amines in terms of CO2 conversion rates, high pressure fixed bed experiments were executed. Steric hindrance and the pKa of the tertiary amine were identified as key parameters influencing both the observed kinetic rates as well as the CO2 conversion. The usage of solventless polar amines such as diethylethanolamine allowed for FA productivity up to 5x that of the benchmark triethylamine system. Catalyst deactivation of the Au/TiO2 catalyst was observed for all amines studied within this work, and the deactivation mechanism was shown to be sintering of the Au nanoparticles with no significant leaching, morphological changes or oxidation of the Au species observed.
Search for clinical, genetic, morphological and immunohistochemical predictors of parathyroid cancer recurrence
Authors: Kim Ekaterina I. , Eremkina Anna K. , Elfimova Alina R. , Mokrysheva Natalia G.
Published: December 2024

Background. Currently, there is no consensus on postoperative risk stratification for parathyroid cancer (PC). The risk factors of disease progression are crucial for choosing the optimal treatment strategy, including adjuvant methods and patient,s follow-up.
Aim. Identifying predictors of PC recurrence
Materials and methods. We performed a retrospective observational study of 85 patients with verified PC divided into remission (n=61) and recurrence (n=19) groups after primary surgical treatment for the period 2004–2023. The analyzed parameters included demographic, laboratory and instrumental data of patients with PC, the presence of a mutation in the CDC73 gene, morphological and immunohistochemical characteristics of the primary tumor.
Results. After adjustments for multiple comparisons, a statistically significant association of recurrence was found for preoperative calcium level (p0.001), pT4 stage (p0.001) according to TNM-classification (Tumor, Nodus, Metastasis) American Joint Committee on Cancer 2017. There was a statistical trend for calcium correction for hypoalbuminemia (p=0.002), presence of nephrolithiasis/nephrocalcinosis (p=0.021), parathyroid hormone level 6 months after primary surgery (p0.05), pT3 stage TNM (p=0.007), nuclear expression of parafibromin in tumor tissue (p0.05). We did not reveal any associations between disease recurrence and sex, age, volume of surgical treatment, germline mutation in the CDC73, parafibromin expression and Ki-67 in tumor tissue.
Conclusion. Our study revealed several factors of poor prognosis, allowing to identify a risk group for recurrence, which can contribute to active dynamic monitoring and timely treatment.
Differential diagnosis of rheumatic manifestations of acromegaly. Case report
Authors: Perepelova Margarita A. , Dzeranova Larisa K. , Panevin Taras S. , Przhiyalkovskaya Elena G. , Pigarova Ekaterina A. , Troshina Ekaterina A. , Zotkin Evgeniy G.
Published: December 2024

Acromegaly is a chronic endocrine disease characterized by excessive secretion of growth hormone, which, in turn, leads to an increase in the secretion of insulin-like growth factor 1 in the liver. The targets for these hormones are most of the cells in our body. Excess growth hormone (in the vast majority of cases caused by hormone-producing pituitary adenoma – somatotropinoma), insulin-like growth factor leads to cellular, and tissue growth of almost all organs and systems, including the osteoarticular apparatus. Diagnosis of the disease in the early stages is often difficult and is established 5–10 years after the onset of symptoms, that leads to various complications and disability of patients. Often joint pain is the first manifestation of acromegaly. Damage to the musculoskeletal system causes a significant deterioration in the quality of life even when long-term stable remission of the underlying disease is achieved. In the article a clinical case with the peculiarities of diagnosing rheumatic disease in acromegaly is presented. A patient aged 56 years was diagnosed with acromegaly based on clinical and laboratory data, and a month later she underwent transnasal adenomectomy. However, Endocrinology Research Centre drew attention to the patient's complaints of pain in large joints, and therefore she was referred for a consultation to a rheumatologist at the Nasonova Research Institute of Rheumatology. As part of the examination, an increase in the titer of the antinuclear factor (1/2560) and the level of antibodies to ribonucleoprotein was revealed, which is most typical for mixed connective tissue disease. Treatment was prescribed and dynamic monitoring is being carried out.
Intermittent fasting: Effectiveness and safety. A review
Authors: Altashina Marina V. , Ivannikova Ekaterina V. , Troshina Ekaterina A.
Published: December 2024

The question of effective ways to treat obesity in people of different ages inevitably affects nutritional principles. Currently, intermittent fasting is of particular interest. There are several variants of intermittent fasting, the common feature of which is periodic temporary breaks in food intake. This review assessed the results of studies on the effectiveness of such a restrictive diet in patients with various pathologies.
Enjeux et défis de la profession notariale au regard de l'instrumentation des directives médicales anticipées :
Authors: Ferron-Parayre Audrey , Lacroix Mariève
Published: December 2024

Le rôle du notaire ne cesse d’évoluer, au fil des changements qui affectent l’ensemble de la société québécoise. Une expression de cette évolution s’apprécie dans l’instrumentation des directives médicales an-ticipées (DMA) par les notaires, possible au Québec depuis le 10 décembre 2015. Face à ce nouvel acte, plusieurs questions pratiques peuvent être dégagées. Quelles sont la nature et la teneur du devoir d’information eu égard aux importantes décisions de san-té qui figurent dans les DMA ? Les notaires ont-ils une obligation spécifique de s’assurer que le client a cherché, reçu et compris certaines informations médicales perti-nentes à la prise de décision qu’il s’apprête à authentifier par acte notarié ? Comment les notaires se sont-ils prépa-rés, en amont de l’entrée en vigueur de la Loi concernant les soins de fin de vie, à recevoir ces nouvelles volontés anticipées ? Et en aval, quels défis rencontrent-ils dans leur pratique au regard des DMA ?
Suivant une méthodologie empirique de type qualita-tive, nous avons questionné la pratique et documenté les perceptions et les attitudes des notaires face aux DMA, no-tamment les enjeux et les besoins rencontrés dans leur pra-tique, de même que les solutions novatrices qui peuvent émerger. Les entretiens semi-dirigés réalisés auprès de dix notaires mettent en lumière que leurs perceptions quant à l’utilité générale des DMA sont positives, mais que leur positionnement professionnel face à cet acte apparaît plus nuancé. Également, notre recherche permet de relever l’inconfort exprimé quant aux aspects de l’instrumentation des DMA touchant plus précisément le consentement aux soins, soit l’aptitude et le devoir de conseil.
Sauvagines (2019) de Gabrielle Filteau-Chiba : déconstruire la chasse et refaire le monde
Authors: Urquhart Steven
Published: December 2024

En empruntant aux théories déconstructionnistes de Jacques Derrida, cet article examine la mise en récit de la pratique de la chasse dans Sauvagines de l’écrivaine québécoise Gabrielle Filteau-Chiba. Sa protagoniste – une agente de protection de la faune – envisage la chasse d’une manière différente de sa conception traditionnelle. Elle remet en question l’hétéronormativité et mène un combat contre l’exploitation de la nature qui culmine dans le piégeage d’un braconnier. Victime des tentatives d’intimidation de ce dernier, la narratrice abandonne son poste et décide de le prendre en chasse. En agissant tel un animal défendant son territoire, la protagoniste commet un acte objectivement illégal, mais légitime d’un point de vue éthique et écologique. Ses actions déconstruisent le rapport de force entre prédateur et proie et relèvent d’une forme de justice poétique. Le trappage fatal du braconnier, ainsi que le caractère symbiotique du rapport que la protagoniste établit avec son amante, soulignent non seulement l’interdépendance entre êtres humains et animaux, mais aussi le respect de la diversité présente dans la nature.
Du bazar au palais du raja : bijoux et costumes d’Orient chez Harriet Murray-Aynsley et Marie de Ujfalvy-Bourdon
Authors: Sudres Sarah
Published: December 2024

L’article examine les récits de voyage et les collections de la voyageuse britannique Harriet Murray-Aynsley et française Marie de Ujfalvy-Bourdon dont les parcours se sont croisés dans l’Inde et l’Himalaya dans la dernière décennie du dix-neuvième siècle. À travers l’étude des enjeux du female gaze dans la représentation de l’Oriental.e dans les scènes traditionnelles de visites aux bazars, les descriptions des harems et zenanas et les visites aux ranis, il s’agira de se demander si les bijoux et vêtements tels qu’ils sont racontés par les voyageuses et rapportés en Europe, permettent de défaire l’Orient fantasmé des hommes, ou s’ils sont pris dans les mêmes schémas d’interprétation et de représentation stéréotypés. En interrogeant la catégorie du genre, il est possible de mettre en évidence une narration de soi et des autres qui obéit à des contraintes de production et de réception du récit féminin, et dessine les contours d’un orientalisme alternatif au discours dominant. La comparaison nationale révèle néanmoins que les enjeux de collecte et de discours sur les objets font pleinement entrer les représentations des voyageuses dans la rhétorique du discours colonialiste et impérialiste.