bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the quality of education activities conducted using telemedicine technologies
Authors: Drapkina O. M. , Volkova I. Yu. , Shepel R. N. , Zhamalov L. M. , Astanina S. Yu. , Vakhovskaya T. V.
Published: July 2022

Aim. To evaluate the quality of education activities conducted using telemedicine technologies and identify most significant factors affecting satisfaction from its participation.

Material and methods. An analysis was made of 2039 questionnaires filled out by observers after educational events. A specially designed questionnaire or checklist consisted of 21 questions concerning the following three main components of the quality of education events: the technical aspect, the content, and the affective evaluation. Digital questionnaires were filled in by observers on the website of the National Medical Research Center for Therapy and Preventive Medicine after educational events. Statistical data processing were carried out using Excel Microsoft Office.

Results. The correlation analysis showed that for developing satisfaction from participation in the educational event (conformity with expectations) for an observer, the most important is the lecture content (r=0,41), how much the lecture helps solving urgent professional issues of physicians (r=0,35), accessibility of the material, communication skills and mastery of the subject matter by the lecturer (r=0,28), structure and logic of the material presentation (r=0,27). Among the significant factors (r=0,23-0,17), we can also highlight the assistance provided by the organizers to resolve various issues, the atmosphere of cooperation and assistance, as well as the completeness of answers to questions from the chat. The lowest value (r=0,16-0,12) has difficulties during registration, the time limits of the event, the availability of preliminary information on the site, the relevance of data presented, the presence of annotations, the quality of communication, visual material and its relevance. Participation of leading experts to conduct educational events is a key indicator of quality, since respondents noted that the availability, statefulness, logical presentation of the material and the communication skills of a speaker are essential establishing audience loyalty.

Conclusion. The results obtained will improve the process of managing educational events held by the National Medical Research Center for Therapy and Preventive Medicine using telemedicine technologies, and improve their quality.
Influence of digital environment on the cognitive function of schoolchildren and students
Authors: Avdeeva E. A. , Kornilova O. A.
Published: July 2022

Aim. To analyze studies on the influence of digital environment on cognitive development of schoolchildren and students.

Material and methods. To achieve this aim, pedagogical research methods were used, which include work with literature on the stated topic, analysis of their content, logical generalization, citation, bibliographic listing, and annotation were used. An important role was played by generalization method and identification of patterns of longterm digital environment influence on a person.

Results. An analysis of the literature has shown that digital environment influence on cognitive development of schoolchildren and students is the subject of research by many authors. One group of scientists considers the digital environment to be a neutral factor in relation to younger generation cognitive function. But, in parallel, studies are being conducted in which scientists has the opposite position. This group includes Russian and Western scientists from Harvard, Oxford, Manchester, Sydney Universities and King’s College London. Over the past twenty years, from 1998 to 2018, they have conducted studies on the impact of electronic devices and the Internet on cognitive functions of the younger generation. In total, 139 papers were published, in which the authors studied the effect of digital environment on cognitive changes from the standpoint of psychology, psychiatry, neurobiology, and other sciences. These studies proved that digital environment affects, first of all, the change in the brain, which acts as a bioplatform for the formation of cognitive functions in schoolchildren and students. And a change in cognitive functions cannot but affect the cognitive processes of attention, memory, thinking, as well as the skills necessary for cognition.

Conclusion. The presented data from Russian and foreign studies revealed facts proving that the digital environment is a factor that changes the cognitive development in children, adolescents and students. The use of the Internet as an ultra-easy way to obtain information leads to the fact that a person blurs the boundaries between his own capabilities and the capabilities of electronic devices, attributing to himself their superpowers.
Innovations in medical education — advantages and risks
Authors: Astanina S. Yu.
Published: July 2022

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FREQUENCY OF ASYMPTOMATIC HUMAN IMMUNODEFICIENCY VIRUS, SYPHILIS, HEPATITIS B AND HEPATITIS C IN CIRCUMCISED MALE PATIENTS DIAGNOSED WITH URETHRITIS
Authors: SİYEZ Ender
Published: July 2022

Aim: In this study, it was aimed to determine the frequency of asymptomatic Human Immunodeficiency Virus (HIV), Hepatitis B, Hepatitis C, and syphilis in circumcised patients diagnosed with urethritis transmitted by sexual intercourse because of unprotected sexual contact.
Material and Methods: We retrospectively investigated the serological results of HIV, Hepatitis B, Hepatitis C, and Syphilis diseases in 364 male patients diagnosed with urethritis, all of them were circumcised during childhood. The study included patients who applied to the urology outpatient clinic of secondary state hospital between January 2017 and December 2019 with symptoms or signs of urethritis. In the examination, only urethral discharge could be seen without symptoms. After the patients were examined, first void urine samples were taken. Also at the first examination, peripheral blood samples were tested for HIV, Hepatitis B, Hepatitis C, and syphilis antibodies.
Results: As a result of retrospective screening of the serological results of 364 male patients diagnosed with urethritis, Hepatitis B positivity was 1.09% with 4 cases, Hepatitis C positivity was found as 0.27% in 1 case and the Syphilis positivity rate was 1.92% with 7 cases in 364 patients. None of the patients had HIV positivity.
Conclusions: The fact that there was not any encounter of HIV-positive patients in patients diagnosed with urethritis because of unprotected sexual contact led to the thought that circumcision had a protective contribution in these patients with urethritis, who were all circumcised. Also, screening tests, especially syphilis, should be performed on all patients diagnosed with STI infection.
Bell’s palsy’s viral pathogenicity and the use of botulinum toxin type A as treatment
Authors: MELARA Abraham , CHANDRA Sathees
Published: July 2022

Bell’s palsy is the common name for the inflammation of the cranial nerve VII. The peculiar geniculate ganglion inflammation is idiopathic and causes hemifacial paralysis. Patients who suffer from this paralysis may have their symptoms dissipate between 3 weeks and 3 months. For certain patients whose facial paralysis persist, botulinum toxin type- A might be an efficient treatment. Depending on the severity of the muscular palsy, different treatments can be offered including surgery, steroid, and anti-viral treatment as well as Botox. This review article’s purpose is to dive into the possible correlation of viral pathogens with the activation of the facial nerve inflammation, and how patients with Bell’s palsy can benefit from Botox type-A as treatment.
The Mental Health Of Turkish Society During The COVID-19 Pandemic
Authors: KAÇER İlker , ÇAĞLAR Ahmet , ÖZTÜRK Berkant , HACIMUSTAFAOĞLU Muhammet
Published: July 2022

Introduction: The novel coronavirus disease (COVID-1 quickly spread all over the world and caused many deaths in Turkey as in the whole world. COVID-19 is potentially lethal and affects the mental health of people. It is important to detect the potential psychological changes in a timely manner during the pandemic. We aimed to determine the anxiety levels and associated risk factors of the society during COVID-19 in Turkey.
Methods: This was a cross-sectional study conducted throughout Turkey during the pandemic. The questionnaires were delivered to the participants via Google Forms. The questionnaire was first published on April 15, 2020, and data were collected for a period of 30 days.
Results: 8,917 questionnaire forms filled out by Turkish society were included in the study. The anxiety level and fear of death were higher in older, females, parents, smokers, people who have comorbidities, social media users, and people who have higher education levels.
Conclusion: The present study is the most comprehensive study conducted in Turkey in terms of the number of participants and sheds light on the mental state of Turkish society during the pandemic. It was determined that COVID-19 has negatively affected the mental health of the population and has increased the anxiety levels and fear of death in Turkey. People who have higher anxiety levels and fear of death should be identified, and psychological support should be provided to these people.
The Changes In The AntiHBs Values Following COVID-19 Pneumonia
Authors: ÖZKAN GÜMÜŞKAYA Perihan , ALTUN Özgür , KARAKÜTÜK YÜZTAŞ Nur , ÖZSOY Neslihan , AYDIN TUTAK Gülten , YILDIRIM Emine , ADAŞ Mine , KÜÇÜK Mehmet
Published: July 2022

Background/aim: We aimed to determine if there is a decrease in antiHBS titer below the protective value during Coronavirus-19 disease (COVID-19).
Materials and methods: A prospective study was made of 67 patients who had positive antiHbs values checked in the last 1 year. Demographic data and the previous antiHBs values were collected from the patient files and the laboratory findings of new antiHBs titers checked after one months later following COVID-19 infection were compared with the previous ones.
Results: In the postcovid evaluation, a statistically significant decrease in the antiHBs levels of COVID-19 patients was determined with respect to previous values before COVID-19 infection (p<0,001).
Conclusion: In our study, we found that there was a statistically significant decrease in AntiHBs levels after COVID-19 infection, but none of them were below protective antiHBs levels. As a result, we can say a booster vaccination against hepatitis B is not needed during or after COVID-19 infection, but it would be appropriate to support it with studies with a higher number of patients.
Does preoperative nutritional assessment affect clinical outcomes in children with acute appendicitis
Authors: BANLI CESUR İlknur , ÖZÇELİK Zerrin
Published: July 2022

Background: Malnutrition increases postoperative complications in pediatric surgical patients.
Objective: The aim of the present study was to examine whether the preoperative nutritional status had any effect on postoperative outcomes in pediatric patients with acute appendicitis who were in need of emergency surgery.
Methods: This retrospective clinical study was carried out at the Department of Pediatric Surgery, Adana City Training and Research Hospital, University of Health Sciences. The study included 74 patients, whose data were analyzed retrospectively. The patients' preoperative Gomez malnutrition classifications and body mass indexes (BMI) were calculated and compared to clinical outcomes.
Results: The study included 74 children who had appendectomy procedures. The mean age was 11.5±3.7 years, 64.9% of the patients in the study were male, while 35.1% were female. The duration of admission to the hospital was 1.77±1.34 days. A BMI cut-off value of less than 16.74 was found to be statistically significant (p<0.001), with 100.0% percent sensitivity and 68.66% specificity. Wound infection was more common in patients with a BMI greater than 16.74 (p=0.010). Low BMI patients were more common in the 0-6 age group and the 7-13 age group (p<0.001).
Conclusion: Nutritional assessment is an essential part of the care of children undergoing surgery. In the present study, we discovered that mild-to-moderate malnutrition before surgery increased postoperative morbidity, hospital stay, and wound infection frequency in children with low BMI. These evaluation systems, in our opinion, will pave the way for positive changes in postoperative management planning.
Can inflammation-based indices describe the poor prognosis in palliative care patients?
Authors: ÜNLÜ Ufuk , YILDIZ ÇELTEK Nagihan
Published: July 2022

Aim: Palliative medicine provides holistic care to increase the quality of life of patients. Predicting prognosis is critical for a personalized treatment plan. Therefore, we aimed to investigate the survival prediction properties of routine biochemistry tests, complete blood count (CBC) and neutrophil/lymphocyte ratios, in addition to biomarker-based indices (the mGPS, PI, and PNI).
Materials and methods: The laboratory parameter values, prognostic factor scores, diagnoses and survival time of 139 palliative care patients in the last 5 weeks of their life were evaluated retrospectively.
Results: Ninety-one (65.5%) patients were male and the average age was 65.9 years (28–91 years). Results of all three prognostic indices (the mGPS, PI, and PNI) investigated in this study were found to have a statistically significant relationship with the survival time of our patients. In addition, NLR, neutrophil percent, hemoglobin, serum albumin and CRP values were seen to have a statistically significant relationship with the scores of all three prognostic indices. Moreover, hand it is detected that WBC, NLR, albumin, and CRP values were associated with overall survival.
Conclusion: The results of our study, which showed that these indices have prognostic markers in palliative care patients, will guide the management of the clinical process. We would like to emphasize the importance of palliative care clinicians in developing personalized treatment plans for patients using prognostic tools for survival prediction.
Clinical Importance of Serum Prolidase and Carbonic Anhydrase III Levels In Patients with Stable Chronic Obstructive Pulmonary Disease
Authors: ÜLGER Mahmut , HOCANLI İclal , KOYUNCU İsmail
Published: July 2022

Aim: Chronic obstructive pulmonary disease (COPD) is a disease characterized by irreversible airway flow limitation and chronic airway inflammation. We aimed to investigate the clinical importance of serum prolidase enzyme, which is an indicator of collagen degradation, and Carbonic anhydrase (CA) III enzyme, which has an important function in acid-base regulation, in patients with COPD
Methods : In this study, 56 stable COPD patients and 32 healthy subjects without smoking history and comorbidities were included. Serum CA III and prolidase enzyme levels were compared between the two groups.
Results: The statistical difference was not found between the two groups in terms of prolidase enzyme levels (p=0.831). There was a statistically significant increase in CA III levels in the COPD group (p=0.001). There were moderate positively correlation between CAIII with partial pressure of carbon dioxide in blood (pCO2) and negatively correlation between CA III with partial pressure of oxygen in blood (pO2) in COPD patients (r:0.302, p<0.025; r:-0.314, p:0.02).
Conclusions: We think that there is an important clinical relationship between CA III and COPD, and therefore, CA III may be a candidate biomarker in the follow-up of COPD.
Short-Term Effect of Sodium Glucose Co – Transporter 2 Inhibitors on Routine Laboratory Examinations
Authors: ŞAHİNER Enes , İNAN Osman
Published: July 2022

Backgroundː In this study, we aimed to examine the effect of Sodium Glucose Cotransporter 2 inhibitors (SGLT-2i) on routine laboratory test results at 12 weeks of follow-up among type 2 diabetes mellitus (T2D) patients using empagliflozin and dapagliflozin.
Methodsː Three hundred ten patients with a diagnosis of T2D (over 18 years of age) with SGLT-2i added to stable triple combination therapy were included in this study. Patients who received either empagliflozin (25 mg once daily) (n:170) or dapagliflozin (10 mg once daily) (n:140) in addition to their current treatment regimen were divided into two groups. Laboratory findings of all patients were recorded before treatment and during follow-up in the 12 weeks.
Resultsː Both empagliflozin and dapagliflozin had similar profiles of improvement of mean fasting blood glucose, and HbA1c. High improvement in lipid profiles and spot urinary parameters were detected in dapagliflozin group compared to empagliflozin group. At 12-week follow-up, change in other laboratory parameters did not differ significantly between the groups. In terms of total side effects, no difference was observed between treatment groups.
Conclusionsː Empagliflozin and dapagliflozin had similar effects on fasting blood glucose and HbA1C at 12-week follow-up, while greater improvement in lipid profiles and urinary parameters was detected in those treated with Dapagliflozin.
The effect of Intermittent fasting on the growth and ghrelin hormone in rats feeding on a standard diet
Authors: GÜNBATAR Nizamettin , BULDUK Bahattin
Published: July 2022

Aim: In this study, the effect of intermittent fasting on growth hormone (GH) and ghrelin was examined in rats that fed on a standard diet without any application that may cause the values to decrease or increase in order to see the net effect of intermittent fasting. Materials and Methods: 12 Wistar albino male rats were divided into the 1st group as Control (standard diet 2.8% crude fat. 23.1% crude protein. 5% crude fiber. 7.1% crude ash and 12.8% moisture) and the 2nd group as the intermittent fasting together with the diet group (with a 24-hour break from the non-consecutive diet for 2 days a week and all food restricted except water). Results: As a result of the analysis, it was found that the growth hormone in the intermittent fasting together with the standard diet group tended to increase compared to the control group, and while this value difference was not statistically significant, the ghrelin level was found to be statistically lower than the control group. Conclusion: As a result, it was found that intermittent fasting tends to increase the level of growth hormone, and to have a decreasing effect on ghrelin level, and it was concluded that it can be considered among the methods to be used to treat obesity and prevent its occurrence.
Precipitating Factors and Clinico-Endoscopic Study of Patients with Hepatic Encephalopathy Type C
Authors: KHOBRAGADE Harshal , MANOHAR Tanuja , SATHAWANE Amol
Published: July 2022

Introduction: Hepatic encephalopathy (HE) is a decline in brain function as a result of severe liver disease and its inadequacy to remove toxins from the body. It is characterized by personality changes, intellectual impairment, and loss of consciousness. This study was conducted to determine the precipitating factors and endoscopic features of hepatic encephalopathy in patients with liver cirrhosis and evaluate the associated clinical features admitted in a tertiary hospital in Central India.
Materials and Methods: This hospital-based descriptive cross-sectional study was conducted from November 2016 to October 2018 on 102 patients with hepatic encephalopathy type C, aged above 18. All patients were carefully examined, relevant investigations performed, and data collected through pre-designed proforma. They were sent for statistical analysis where categorical outcomes were compared between study groups using the Chi-square test /Fisher's Exact test.
Results: The prevalence of HE was 19.6% in our study. In this study, we observed that constipation (26.5%), electrolyte imbalance (21.6%), renal failure (18.6%), and upper GI bleeding (18.6%) be among the leading precipitants for HE. Besides liver failure, the associated abnormalities in various factors like coagulation abnormalities, renal derangement, and changes in serum sodium levels can lead to the progression of HE to higher grades.
Conclusion: It is essential to identify the different factors like constipation, electrolyte imbalance, renal failure, and upper GI bleeding early in the course of cirrhosis to help prevent the development of HE.
New Threats, Old Challenges: Understanding Roman Imperialism in Post-Soviet Russia
Authors: Baryshinkov Anton
Published: July 2022

Russian scholars who want to study the Roman Empire, its provinces, and theoretical aspects of Roman imperialism face issues such as the notable disfavour for theoretical re-thinking and debate (a striking contrast to Western academia). This has largely been determined by specific features of Russian academic tradition that have seen it distance from an anti-imperialist and Marxist political tool towards a neutral space that is anti-ideology with a bias against ‘hot’ topics. Other problems are created by the political context and socio-economic conditions of academics. To add to this, scholars are underpaid, underrated, overexploited, and act within a specific public discourse that is filled with imperial nostalgia. This paper discusses these issues and some of the key features of contemporary Russian scholarship on the Roman Empire and imperialism; special attention is given to Marxist legacy of Soviet scholarship and its potential for future studies of the Roman Empire. Possible strategies to deal with these factors are briefly discussed at the end.
Colorimetric Paper-Based Dual Indicator Label for Real-Time Monitoring of Fish Freshness
Authors: Kuswandi Bambang , Hasanah Faridatul , Koko Pratoko Dwi , Kristiningrum Nia
Published: July 2022

Research background. Fish freshness and quality monitoring are of high importance
for consumers, retailers and fishing industry. Therefore, developing novel approaches that are simple, fast, non-destructive and inexpensive to monitor fish freshness in real time is of great value. One alternative is using Intelligent or smart packaging to monitor the freshness or conditions of packaged fish.
Experimental approach. On-package dual indicator label based on paper-based pH sensors was developed for real-time monitoring of the milkfish (Chanos chanos) freshness. The paper-based pH sensor was prepared using bromocresol purple (BCP) and bromothymol blue (BTB) that were immobilized onto a filter paper by dip coating. Herein, the fish degradation could be monitored visually by the dual indicator label, where the BCP changes from yellow to pink, then finally to purple, while the BTP changes from orange to green-yellow, and finally to green-blue to indicate fresh, medium fresh or spoiled product, respectively.
Results and conclusion. The label responds to the pH change caused by the fish degradation and the colour of dual indicator changes to show the fish freshness at room temperature and chiller conditions. This pH change was followed by changes in the other parameters related to fish freshness, such as total volatile basic nitrogen (TVBN), total viable count (TVC), texture and odour. The threshold of fish spoilage at room temperature was observed at 8 h and under chiller conditions at 7 days when the deterioration time point was indicated by the colour changes. Thus, it can be concluded that the dual indicator label can be applied as a simple and low-cost on-package active label for fish freshness monitoring.
Novelty and scientific contribution. Increasing consumer concerns about quality and safe food worldwide has boosted the search for a novel approach to food monitoring. In this work, a simple and practical on-package dual indicator label for real-time monitoring of fish freshness was developed. The colorimetric pH sensor was obtained simply by dip-coating of filter paper, yet it enables easy and accurate detection of fish spoilage with the naked eye. Similarly, the dual indicator labelchanges colour for other freshness parameters, such as TVBN, TVC, texture and odour.
Gluten-Free Crackers Based on Chickpea and Pumpkin Seed Press Cake Flour: Nutritional, Functional and Sensory Properties
Authors: Tomić Jelena , Škrobot Dubravka , Popović Ljiljana , Dapčević-Hadnađev Tamara , Čakarević Jelena , Maravić Nikola , Hadnađev Miroslav
Published: July 2022

Research background. Despite the growing trend of the gluten-free market and the
presence of a wide range of gluten-free products, there are still some shortcomings in nutritional and sensory quality of these products. The commercially available gluten-free products are characterised as products of inferior nutritional quality, particularly in terms of protein and dietary fibre content and with high glycaemic index. On the other hand, from a sensory point of view, gluten-free products usually have inappropriate textural and mechanical properties, poor mouthfeel and flavour. This is a consequence of the limiting choice of raw materials that mainly possess large amount of carbohydrate components.
Experimental approach. Chickpea flour and two types of pumpkin seed press cake flour
(virgin and cold pressed), at two substitution mass fractions (20 and 35 %), were blended to produce gluten-free crackers without the presence of conventional gluten-free starch-rich ingredients. This study aims to investigate the effect of these non-conventional flours on nutritional and physicochemical properties, sensory acceptability, antioxidant activity and glycaemic index of crackers.
Results and conclusions. All produced crackers can bear nutritional claims ’high fibre’,
’source of protein’ and ’source of minerals’. Replacing chickpea flour with pumpkin seed
press cake flour increased protein and total phenolic content and enhanced antioxidant
activity. The selected combination of raw materials allows the production of gluten-free
crackers with a moderate glycaemic index. Besides nutrient content, the addition of cold-pressed flour increased overall sensory acceptability, noticeably improving taste and flavour scores compared to the control and crackers with virgin pumpkin seed flour.
Novelty and scientific contribution. To the best of our knowledge, there is no study investigating the use of chickpea and pumpkin seed press cake flour blend without using conventional gluten-free flour and starch. The used non-conventional flour represents complementary raw materials in terms of protein quality and valuable alternatives to produce nutrient-rich, health-promoting gluten-free crackers with reduced glycaemic response and acceptable sensory properties.
Yeast Multi-Enzymatic Systems for Improving Colour Extraction, Technological Parameters and Antioxidant Activity of Wine
Authors: Longhi Sara Jaquelina , Martín María Carolina , Merín María Gabriela , Morata de Ambrosini Vilma Inés
Published: July 2022

Research background. Wine yeasts are a heterogeneous microbial group with high enzymatic potential that makes them a useful tool in winemaking. With a better understanding of their oenological properties, selection procedures can be optimised to obtain more efficient strains. The present study aims to isolate and select yeasts from wine grape surface by studying their production of enzymes that hydrolyse plant cell wall polymers and by linking them to different technological parameters and antioxidant activity of wines.
Experimental approach. Yeasts that are able to produce carbohydrolases and related
enzymes of oenological importance were firstly selected on plates and subsequently identified. Then, a secondary selection of yeasts was carried out according to technological effects of their extracellular enzyme extracts on short macerations. In this way, the colour extraction, total polyphenol content, clarification, filterability and antioxidant activity were studied. This approach makes it possible to correlate the microorganism capacity to produce cell wall-depolymerizing enzymes with their technological effects.
Results and conclusions. From 366 isolates, 96 strains (26.2 %) showed at least one of the polysaccharidase activities and 55 strains (57.3 %) of them exhibited activities of multiple enzymes that degrade plant cell wall polymers. Sixteen strains were selected and identified as Aureobasidium, Candida, Debaryomyces, Hanseniaspora, Metschnikowia, Pichia, Saccharomyces and Torulaspora. Pectinolytic enzymes had the highest hydrolytic activity. Aureobasidium pullulans had a broader enzyme blend and higher activity, dominated by pectinases and followed by xylanases and cellulases. Moreover, the Torulaspora delbrueckii m7-2 strain produced high amounts of polysaccharidase and this was strain-dependent.
Strains that produced enzyme extracts with a wide range of activities that were also the
highest, also had the best chromatic and technological properties. Cluster analysis confirmed that A. pullulans R-22, m11-2, m86-1 and m86-2 and T. delbrueckii m7-2 could be correlated with a better effect on filterability, clarification and extraction of bioactive compounds, encouraging future studies regarding their application in winemaking.
Novelty and scientific contribution. The study of yeast multi-enzymatic systems impacting the grape maceration process enables a proper selection criterion for wine yeasts to improve colour extraction, technological parameters and antioxidant activity of Malbec wine. This work shows that A. pullulans and T. delbruekii have a high enzymatic potential for oenological purposes.
Açık Alan Rekreasyon Faaliyetleriyle İlgili Zoonoz Riski Algısı
Authors: TOKER Fidel , BARAN AKSAKAL Fatma Nur
Published: July 2022

Zoonoz olarak bilinen ve hayvanlardan insanlara doğrudan temas yoluyla veya gıda, su ve çevre ile bulaşabilen hastalık, Birleşmiş Milletler Dünya Sağlık Örgütü (DSÖ) verilerine göre yılda 2,5 milyar insana bulaşmakta, bunlardan 2,7 milyon kişinin ölümüne neden olmaktadır. Son zoonoz salgını olarak COVID-19, ilk vakanın ardından insandan insana bulaşarak iki yıl içinde 280 milyona yakın kişiyi etkilemiş, 5,5 milyon dolayında ölüme yol açmıştır. Zoonozlar bilhassa açık rekreasyon alanlarında, sağlığını korumak amacıyla gönüllü boş zaman etkinliklerine katılan bireyler için risk oluşturabilmektedir. Bu çalışma bireylerin hayvanlardan geçen hastalıklar olan zoonozlar konusundaki bilgi düzeyini ve zoonoz riski algısının açık alan rekreasyon faaliyetleri katılımıyla ilişkisini ölçmek amacıyla gerçekleştirilmiştir. Ankara’nın Gölbaşı ilçesinde yer alan ve zoonoz riskinin yüksek olabileceği sulak araziler olan Mogan ve Eymir Gölü’ne yakın Aile Sağlığı Merkezlerine (ASM) başvuran 474 yetişkin bireyle yüz yüze görüşülerek anketi yanıtlamaları sağlanmıştır. Sonuçlar zoonozun risk olarak algılanmadığını ve farkında olunsa bile rekreasyona katılımda çekince yaratmadığını ortaya koymaktadır.
Prediction of pathologic complete response prediction in patients with locally advanced esophageal squamous cell carcinoma treated with neoadjuvant immunochemotherapy: a real-world study
Authors: Feng Jifeng , Wang Liang , Yang Xun , Chen Qixun , Cheng Xiangdong
Published: July 2022

As an emerging hotspot for patients with locally advanced esophageal squamous cell carcinoma (LA-ESCC), neoadjuvant immunochemotherapy (nICT) is safe and feasible. Pathological complete response (pCR) is considered to be an important therapeutic effect of neoadjuvant therapy. However, few studies have explored pCR predictors for nICT in LA-ESCC. The purpose of this study was to predict pCR after nICT in LA-ESCC by pretreatment clinical characteristics and hematological indexes. The primary endpoint was to explore the impacts on the predictors for pCR prediction. Clinical characteristics and hematological indexes including systemic immune-inflammation index (SII), neutrophil lymphocyte ratio (NLR), lymphocyte monocyte ratio (LMR), prognostic nutritional index (PNI) and platelet lymphocyte ratio (PLR) were conducted. A total of 150 LA-ESCC patients were enrolled in the current study. There were 14 (9.3%) female and 136 (90.7%) male patients. Fifty-two patients achieved pCR (34.7%). A higher pCR rate was found in low-NLR group (43.7% vs. 26.6%, P=0.028) and high-LMR group (43.8% vs. 21.3%, P=0.004), respectively. Differentiation [odds ratio (OR) =0.464, 95% confidence interval (CI)=0.259-0.830, P=0.010], LMR (OR=0.309, 95% CI=0.132-0.707, P=0.007) and cTNM (OR=0.225, 95% CI=0.115-0.441, P<0.001) were independent predictors for pCR. The nomogram for pCR prediction based on LMR, differentiation and cTNM stage had good discrimination performance and calibration coordination (C-index=0.779). The results of our study are of great significance for designing therapeutic strategies. Nomogram based on LMR, differentiation and cTNM may accurately and effectively predict pCR.
DIGITAL ADDICTION IN ADOLESCENTS AND AFFECTING FACTORS
Authors: YÜCEL Ali Serdar , KORKMAZ Murat , SEVİL Ümran , BAYRAM DEĞER Vasfiye , ÖZTAŞ Dilek , BAL Fatih , GÜRKAN Ayça
Published: July 2022

Amaç: Bu çalışmanın amacı, öğrenciler üzerinde dijital bağımlılığa etki eden bazı demografik ve psikografik etkenlerin incelenmesidir. Gereç ve Yöntem: Çalışma İstanbul, İzmir, Ankara, Mardin illerini kapsamaktadır. Örneklemini ise belirlenen illerdeki 987 öğrenci oluşturmuştur. Çalışma betimsel tarama modeli niteliğindedir. Çalışmada anket (survey) tekniği kullanılmıştır. Çalışmada kullanılan ölçek formu araştırmanın yazarları tarafından geliştirilmiş ve hazırlanmıştır. Çalışmada elde edilen verilerin analizinde SPSS 18.0 yazılımı kullanılmıştır. Ayrıca analiz kapsamında, betimleyici istatistikler, güvenilirlik analizi, bağımsız örneklem t-testi, Anova analizi ve Faktör analizlerinden yararlanılmıştır. Tüm istatistik analizleri 0.05 anlamlılık düzeyinde test edilmiştir. Bulgular ve sonuç: Çalışma sonunda internete yönelik eğilim faktörleri, internet çocuk ve eğitim, internetin çocuklar üzerindeki güven duygusu, internet aile ve çevre ve bireysel internet kullanımı ve internet algısı boyutlarının günlük internet kullanımı, cep telefonu kullanımı, internette yapılan aktiviteler, internet için kullanılan cihaz ve internet için kullanılan yöntemden bağımsız olduğu, genel internet kullanımının ise İnternet aile ve çevre boyutu ile Bireysel internet kullanımı ve internet algısı boyutlarından bağımsız olmadığı sonucuna ulaşılmıştır.
[RETRACTED] Nucentix Keto X3 Review - Shark Tank Alert of Keto X3, Read Pros & Cons! v1
Authors: Hq Keto Gummies Vitality
Published: July 2022

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Nucentix Keto X3
[RETRACTED] Ez Burn Keto Gummies CanadaReviews! Shocking Benefits! Scam Or Legit! v1
Authors: Burn Keto Gummies Canada Ez
Published: July 2022

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What are EZ Burn Keto Gummies? Official Website – Click Here Weight reduction supplement these Gummies advances solid digestion and normal weight reduction. When taken, they can empower fat capacity by animating the body to involve put away fat as energy. Exogenous ketones, or BHB salts, are otherwise called BHB salts, and that implies that as opposed to framing normally in the body, they are made remotely and consumed remotely. There are claims that these Gummies creators can support weight reduction and even diminish hunger.According to these Gummies' true site, it has a large number of similar impacts and advantages as a ketogenic diet. These Gummies are supposed to have the option to keep you in ketosis regardless of whether you eat a moderate measure of starches. The item professes to work by subbing starches for fat. It's showcased to individuals who need to shed pounds. https://www.facebook.com/EzBurnKetoGummiescanadaReview/ https://www.facebook.com/EzBurnKetoGummiesReview/ https://www.mastersindia.co/q/ez-burn-keto-gummies-canada-shocking-alert-2022/ https://www.mastersindia.co/q/ez-burn-keto-gummies-canada-100-clinically-certified-ingredients/ https://ezburn-canada.clubeo.com/page/ez-burn-keto-gummies-canada-does-it-work-for-weight-loss.html https://ezburn-canada.clubeo.com/page/ez-burn-keto-gummies-canada-scam-legit-updated-result-2022.html https://www.scoop.it/topic/ez-burn-keto-gummies-canada-reviews-see-how-it-does-work https://www.scoop.it/topic/ez-burn-keto-gummies-canada-by-ez-burn-keto-gummies-82 https://www.cos.youth4work.com/Ez-Burn-Keto-Gummies-2022/jobs/176985-ez-burn-keto-gummies-canada-scam-alert-read-this-before-buy-in-Toronto https://www.cos.youth4work.com/Ez-Burn-Keto-Gummies-2022/jobs/176986-ez-burn-keto-gummies-canada-is-it-safe-a-real-consumer-experience-in-Toronto https://forum.techtudo.globo.com/perguntas/342388/ez-burn-keto-gummies-canada-does-it-work-what-they-wont-tell-you
[RETRACTED] [Exposed] Stimula Blood Sugar Support Reviews - ( Scam Alert ) Ingredients, Side Effects Do The Pills Work? Don't Miss This Report! v1
Authors: solan trina
Published: July 2022

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If you've been feeling tired and lethargic for the past few months, yet nothing seems to help or change your symptoms, your blood sugar level may be high.
[RETRACTED] Cardiologist v1
Authors: rAKathy Kathy rAKathy. Davis Dr
Published: July 2022

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Heart failure monitor decision diagnosed medical condition needing medication results heart attack know further then artery blocking the valve stopping blood flow to the cause heart attack. considered as heart failure monitor access proper way to make decision.second opinion could be option if not comfortable with heart failure diagnosed medical condition of EKG complaint of emergency further examine with high blood pressure cholesterol levels results of lab work basic level high pressure cholesterol extremely high above normal range pressure unstable condition heart attack smoking causing different type of reaction of health condition drinking alcohol level basic witn test abnormal specimen was identify causing pain with the substance but wasn't aware of heart attack upon visit to emergency room with alcohol level .
[RETRACTED] Nordic CBD Gummies Australia Reviews - Nordic CBD Gummies Australia Chemist Warehouse in 2022 v1
Authors: not provided znfdbzldf
Published: July 2022

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Nordic CBD Gummies Australia Reviews:- A strong body and an ordinary mind are we need nowadays. Notwithstanding, this ongoing truth is stacked down with standard activities that could show either disturbing, depleting, or bleak.
[RETRACTED] Prodentim Australia, NZ, Ireland, Canada or UK v1
Authors: Australia Prodentim
Published: July 2022

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ProDentim supplements include several ingredients that work on the mouth, tooth, gum, and breath. In addition, the components are beneficial for the whole body. ProDentim works on many levels to improve dental health gradually and effectively. It aids in the removal of most tooth and gum problems and conditions such as tartar, cavities, and plaque. It works very well due to the specially selected components. These substances work well because they have been combined in the right proportions. In the preparation, the manufacturer did not use any artificial additives or dangerous substances. Prodentim Official Web Click Here :- https://www.outlookindia.com/outlook-spotlight/prodentim-reviews-australia-nz-2022-scam-or-legit-prodentim-canada-price-buy-in-prodentim-uk-ireland-or-united-states-news-211409/amp
[RETRACTED] Via Keto Apple Gummies Australia Reviews- Price or Chemist Warehouse Buy v1
Authors: not provided health
Published: July 2022

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Via Keto Apple Gummies - Natural products are always a better choice due to their medicinal potential and guaranteed safety.
[Exposed] Stimula Blood Sugar Support Reviews - ( Scam Alert ) Ingredients, Side Effects Do The Pills Work? Don't Miss This Report! v1
Authors: solan trina
Published: July 2022

If you've been feeling tired and lethargic for the past few months, yet nothing seems to help or change your symptoms, your blood sugar level may be high.
[RETRACTED] WAS IST Dieatovita und wie wirkt es? v1
Authors: not provided Eaharastcoumer
Published: July 2022

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DIEATOVITA ist ein revolutionäres Medikament, das fettleibigen Menschen hilft, Gewicht zu verlieren und ihren Stoffwechsel zu verändern. Laut der offiziellen Website handelt es sich um eine Mischung aus Pflanzenstoffen, die aus seriösen Quellen stammen und in Kapselform verpackt sind. Diese Pillen helfen dabei, hartnäckiges Körperfett zu verbrennen und den Körper so zu konturieren, dass er straff und frei von schlaffer Haut erscheint.
[RETRACTED] Stimula Blood Sugar Support Reviews ( Scam Alert ) Ingredients, Do The Pills Work? Don't Miss This Report! v1
Authors: solan trina
Published: July 2022

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If you've been feeling tired and lethargic for the past few months, yet nothing seems to help or change your symptoms, your blood sugar level may be high.
[RETRACTED] F1 Keto Acv Gummies Reviews – [ REAL Or Fake? ] Where To Buy Get Exclusive Discount? Important Facts and Stacks you Need to Know! v1
Authors: siaecker donnaz
Published: July 2022

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F1 Keto ACV Gummies - is a recently released ketogenic formula that is getting a lot of hype and demand in the market in the past few weeks. From all this hype and demand, most people can conclude that the supplement is legitimate, but thorough research on every aspect of this weight loss supplement is necessary to reach a final decision about it.
[RETRACTED] Dietavita Erfahrungen v1
Authors: not provided polbatra
Published: July 2022

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https://healthcare24hrs.com/diaetovita/
[RETRACTED] Condor CBD Gummies Reviews: (Shark Tank Scam) Price & Amazon Ingredients or Where to Buy Condor CBD Gummies? v1
Authors: solan trina
Published: July 2022

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Condor CBD Gummies supplement. But to confirm its effectiveness, safety and quality, it is necessary to penetrate it and analyze it from top to bottom.Condor CBD Gummies review, as it contains a full description of a working remedy that has helped many people with similar situations recently.
. Improving the Supporting Business Processes of Higher Educational Institutions to Improve the Efficiency of Educational Service Organizations
Authors:   ITMO University, Pechnikov K.I. , Silakova L.V. ,   ITMO University
Published: July 2022

The article examines the processes and systems of employee motivation in the achievement of their KPI’s as an element of the implementation of university development programs. The following business processes in employee motivation systems of seven higher educational institutions were analyzed: determination of key performance indicators of employees, collection of data on the fact of the implementation of measures affecting the implementation of key performance indicators of employees, data verification (confirmation of the fact of the implementation of measures) by responsible persons, resolution of conflict situations related to the need to revise the results of data verification, calculation of allowances. Five diagrams in UML 2.0 notation describing these processes were compiled for them. The conclusion was made about the similarity of the mentioned motivation systems. Based on the above, it is possible to automate emerging processes by developing a special information system. The results of the study formed the basis for the development of a system of motivation and planning for the implementation of KPIs by university employees, which was implemented at the National Research University of MEI, which showed efficiency due to automation of management.
Emotional Marketing as a Tool to Increase Employee Engagement and Develop Internal Brand of the Company
Authors:   ITMO University, Iost I.A. , Girsh L.V. ,   ITMO University, Soloveva D.V. ,   ITMO University
Published: July 2022

The article discusses the concept of emotional marketing as a tool to increase employee engagement. The review of the situation on the market of innovatively active companies is carried out, dependencies and influence on the attitude of employees to companies and their internal brands are revealed. The data of mass and in-depth surveys of employees are presented and relevant conclusions are drawn on them. The typology of the audience of the internal brand of a foreign company leaving the Russian market is proposed. Strategic emotional directions in the development of internal branding in innovative and active companies are highlighted and tactical tools for working with the development of involvement in the internal brand are presented.
Trading the Russian Technology to the Arab Gulf States
Authors:   ITMO University, Shadad N.A.M. , Kudinov I.A. ,   ITMO University
Published: July 2022

Russia's contribution to offering innovative technologies to Arab Gulf states is limited. Arab Gulf states are interested in breakthrough technologies and diverse innovations of the best quality. In this article we will study the potential of Russian technology trading with Saudi Arabia, United Arab Emirates and Qatar.
Methods and Models for Monitoring the Development of Hydrogen Production Technologies and Associated Decarbonization Based on the Analysis of Ultra-Large Patent Collections
Authors:   Project Office of the Federal Institute of Industrial Property, Ena V.O. , Batanov F.A. ,   Project Office of the Federal Institute of Industrial Property
Published: July 2022

In conditions of rapid technology changes rates, constant emergence of new product groups and value chains, the demand for qualitative analysis of patent and other scientific and technical information is growing more and more. Patent analytics in that regard should be comprehensive, apply universal approaches regardless of the subject and provide practical recommendations in the shortest possible time. Interest in patent analytics in the context of the tasks of managing science, technology and innovation at the state level is expressed in a wider range of research. Following significant increase in the size of patent collections subjected to analysis, can result in the overall quality drop of work and an increase in labor costs for collection, analysis and interpretation of patent data. This article is devoted to the features of optimizing work with the so-called. super-large collections (over 6,000 patent documents), and offers an adaptation of the traditional approach to building a patent landscape.
Development of the Pharmaceutical Industry in Russia: Systemic Problems and Prospects
Authors:   ITMO University, Lisitskiy N.N. , Antokhin Yu.N. ,   СПб НИИ ЛОР
Published: July 2022

The paper considers the documents of strategic as a factor of pharmaceutical industry growth. The chronology of formation and current directions of state policy of pharmaceutical industry development are considered. The system problems are identified and promising directions of development in the context of public procurement, export potential and management system are formulated.
Сonceptual Models of Computer Games in the Tasks of Managing the Involvement of Students in the Learning Process
Authors:   ITMO University, Untila A.A. , Gorlushkina N.N> ,   ITMO University
Published: July 2022

The article considers the opportunities of managing the student engagement in the study process by using gamification technologies. The elements, mechanics, gamification models and their influence on the learners’ involvement in the acquisition of new knowledge and skills are analyzed. The existing gamification models are considered. The algorithm of teacher's actions when introducing gamification technologies into the educational process is presented. The students’ preferences for gamification technologies implemented in the academic process are revealed. Their interest in such technologies is shown.