bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the Influence Physical Education on Character Development of Elementary School Students
Authors: Kamaruddin Ilham , Susanto Nugroho , Hita I Putu Agus Dharma , Pratiwi Emy Yunita Rahma , Abidin Dindin , Laratmase Antonia Junianty
Published: June 2023

Penelitian ini bertujuan untuk menganalisis pengaruh pendidikan jasmani terhadap pembangunan karakter siswa sekolah dasar. Latar belakang penelitian ini adalah pentingnya pendidikan jasmani dalam pembentukan karakter siswa di usia dini, mengingat karakter yang baik dapat membantu siswa dalam menghadapi tantangan dan situasi kehidupan di masa depan. Metode yang digunakan dalam penelitian ini adalah studi literatur, dengan mengumpulkan data dari sumber-sumber terpercaya seperti jurnal ilmiah, buku, dan artikel terkait. Analisis data dilakukan dengan menggunakan teknik content analysis untuk mengidentifikasi faktor-faktor yang berkontribusi terhadap pengaruh pendidikan jasmani pada pembangunan karakter siswa. Hasil penelitian menunjukkan bahwa pendidikan jasmani dapat membantu siswa dalam membentuk karakter yang baik seperti disiplin, kerja keras, percaya diri, kerjasama, dan lain sebagainya. Selain itu, pendidikan jasmani juga dapat membantu meningkatkan kesehatan fisik dan mental siswa. Berdasarkan hasil analisis, kesimpulan yang dapat diambil adalah bahwa pendidikan jasmani memiliki pengaruh yang signifikan terhadap pembangunan karakter siswa sekolah dasar. Oleh karena itu, pendidikan jasmani harus diberikan dengan serius dan terintegrasi dengan kurikulum sekolah untuk memastikan bahwa siswa dapat mengembangkan karakter yang baik dan sehat secara holistik.
Diagnóstico e fortalecimento da produção de morangos no município de Canoinhas – Santa Catarina
Authors: Palhano Metka Samanda , Moraes Juliana , Munhoz Leite Elcio Lucas , Pires Neto Nabor , Stange Almeida Rabechlt , Simão Sudoski Diogo , Ribeiro Fernandes Mateus , Würz Douglas André
Published: June 2023

A cultura do morango desempenha importante papel na agricultura familiar. No entanto, muitos produtores não conseguem acompanhar a evolução do setor, reduzindo a competitividade da cultura, sendo necessário o conhecimento da realidade local da produção de morangos para que a assistência técnica possa identificar os gargalos específicos e propor ou divulgar os sistemas de produção mais adequados. Nesse contexto, tem-se como objetivo deste trabalho relatar o projeto de extensão realizado por discentes do curso superior bacharelado em Agronomia, IFSC Campus Canoinhas. Tal projeto teve por finalidade diagnosticar e fortalecer a cadeia produtiva do morangueiro em Canoinhas/SC. O projeto teve abrangência municipal, tendo como objetivo principal: realizar o diagnóstico do cultivo do morangueiro, identificando os principais entraves na cadeia produtiva, promovendo capacitações aos produtores rurais que cultivam o morangueiro no município de Canoinhas/SC. Com a realização do projeto foi possível não só realizar o diagnóstico da produção de morangos no município de Canoinhas/SC, como também identificar as principais demandas e os principais entraves dos produtores rurais na produção de morangos. O presente projeto possibilitará o desenvolvimento de futuras ações e projetos de extensão a fim de fortalecer a cultura do morangueiro no município de Canoinhas/SC.
Implantação de unidade demonstrativa para cultivo de oliveiras no Planalto Norte Catarinense
Authors: Schmidt Eduarda , Würz Douglas André , Afonso de Maceso Tiago , Palinguer Rodrigo , Matheus Altmann Henry , Virmond Souza Farias Eduardo , Frederico Steidel Otavio , Eduarda Demetrio Kelly
Published: June 2023

A cultura da oliveira tem sido plantada em pequenas e grandes propriedades, além de muitas regiões brasileiras que apresentam clima subtropical ou temperado. Diante da necessidade de avaliar a adaptação da cultura da oliveira e observar seu desempenho agronômico, implantou-se uma unidade demonstrativa para produção de oliveiras no Planalto Norte Catarinense. O projeto é uma parceria público-privada, com a participação do Instituto Federal de Santa Catarina – Campus Canoinhas, Agromillora – Produção e Comércio de Mudas Vegetais e Casa Dom Pedro de Canoinhas/SC. O plantio das mudas de oliveira ocorreu em abril de 2022. Realizou-se o plantio de cinco variedades, sendo: Arbequina, Arbosana, Koroneiki, Lecciana e Oliana, num espaçamento de 4,0 m entre filas x 1,50 m entre plantas. Em agosto de 2022, foi executado a primeira avaliação vegetativa das plantas. A unidade demonstrativa, além de gerar dados técnico-científicos, tem uma importância relevante para troca de experiências, servindo de referência para extensionistas rurais, estudantes e profissionais da área. A unidade demonstrativa fica disponível a visitações agendadas, para conhecer sobre a cultura e acompanhar o desenvolvimento das plantas. Os dados preliminares de desenvolvimento das plantas são promissores, no entanto, há a necessidade de conduzir e avaliar a adaptação da cultura na região por um período maior, a fim de haver maior segurança para sua indicação, bem como das cultivares mais adaptadas para a região e práticas de manejo a serem adotadas.
Dynamic docking assisted engineering of hydrolase for efficient PET depolymerization
Authors: Su Tianyuan , Zheng Yi , Li Qingbin , Liu Pan , Yuan Yingbo , Dian Longyang , Wang Qian , Liang Quanfeng , Qi Qingsheng
Published: June 2023

Poly(ethylene terephthalate) (PET) is the most abundant polyester plastic and is causing serious environmental pollution. Rapid biological depolymerization of PET waste at large scale requires powerful engineered enzymes with excellent performance. Here, we designed a computational strategy to analyze the ligand affinity energy of enzymes to PET chains by molecular docking with the dynamic protein conformations, named Affinity analysis based on Dynamic Docking (ADD). After three rounds of protein engineering assisted by ADD, we drastically enhanced the PET-degrading activity of leaf-branch-compost cutinase (LCC). The best variant LCC-A2 degraded >90% of the pretreated, post-consumer PET waste into corresponding monomers within 3.3 h, and over 99% of the products were terminal degradation products (terephthalic acid and ethylene glycol), representing the fastest PET degradation rate reported to date. Structural analysis revealed interesting features that improved the ligand affinity and catalytic performance. In conclusion, the proposed strategy and engineered variants represent a substantial advancement of the biological circular economy for PET.
Exploring the frontiers of condensed-phase chemistry with a general reactive machine learning potential
Authors: Messerly Richard , Zhang Shuhao , Makoś Małgorzata , Jadrich Ryan , Kraka Elfi , Barros Kipton , Nebgen Benjamin , Tretiak Sergei , Isayev Olexandr , Lubbers Nicholas , Smith Justin
Published: June 2023

Reactive chemistry atomistic simulation has a broad range of applications from drug design to energy to materials discovery. Machine learning interatomic potentials (MLIPs) have become an efficient alternative to computationally expensive quantum chemistry simulations. In practice, developing reactive MLIPs requires prior knowledge of reaction networks to generate fitting data and refitting to extensive datasets for each new application. For this reason, many fields of chemistry would greatly benefit from a general reactive MLIP, i.e., an MLIP that is applicable to a broad range of reactive chemistry such that it can be applied to new systems without the need for retraining. In this work, we develop a general reactive MLIP through unbiased active learning with an atomic configuration sampler inspired by nanoreactor molecular dynamics. The resulting potential (ANI-1xnr) is then applied to study five distinct condensed-phase reactive chemistry systems: carbon solid-phase nucleation, graphene ring formation from acetylene, biofuel additives, combustion of methane and the spontaneous formation of glycine from early-earth small molecules. In all studies, ANI-1xnr closely matches experiment and/or previous studies using traditional model chemistry methods. As such, ANI-1xnr proves to be a highly general reactive MLIP for C, H, N, and O elements that does not need to be refit for each application, enabling high-throughput in silico reactive chemistry experimentation.
Improved metaheuristic based cluster scheduling for unmanned aerial vehicles
Authors: Mann Palvinder Singh , Panchal Shailesh D , Singh Satvir
Published: June 2023

Selection and scheduling of cluster head is a well known optimization problem in Unmanned aerial vehicles (UAVs), which affects overall network performance. Population-based metaheuristic particularly Artificial bee colony (ABC) has shown to be competitive over other metaheuristics for solving optimization problems in UAVs. However, its search equation contributes to its insufficiency due to poor exploitation phase and low convergence rate. This paper, presents an improved artificial bee colony (iABC) metaheuristic with an improved search equation, which will be able to search an optimal solution to improve its exploitation capabilities moreover, in order to increase the global convergence of the proposed metaheuristic, an improved approach for population sampling is introduced through Student's-t distribution. The proposed metaheuristic maintain a balance between exploration and exploitation search abilities with least memory requirements, with the use of first of its kind compact Student's-t distribution, which is particularly suitable for UAVs limited hardware environment. Further utilising the capabilities of the proposed metaheuristic, an improved artificial bee colony based clustering and scheduling (iABC-CS) scheme is introduced, to obtain optimal cluster heads (CHs) along with optimal CH scheduling in UAVs. Simulation results manifest that iABC-CS outperform over other well known clustering algorithms on the basis of packet delivery ratio, energy consumption, network lifetime and end to end delay.
Glutamine/Serine/Glycine concentration related KDM4A expression regulated cisplatin sensitivity in gastric cancer cells
Authors: Xu wenxia , Fu junhao , Ni yuqi , Hu yuqing , Tang wanfeng , Fu jianfei , Wang yue
Published: June 2023

Gastric cancer is a high incidence of digestive system tumors, and the existence of drug resistance reduces the sensitivity to chemotherapy. Nutritional therapy can significantly improve the prognosis of tumor patients. Dietary amino acids play an important regulatory role in tumor gene expression, epigenetics, signal transduction, metabolic remodeling and other processes. This study found that glutamine, glycine and serine could significantly regulate the sensitivity of gastric cancer cells to cisplatin by screening 20 amino acids. When the concentration of glutamine, glycine and serine decreased, KDM4A underwent acetylation to maintain protein stability, activate DNA repair ability, and reduce the sensitivity of gastric cancer cells to chemotherapy. Conversely, when the concentration of glutamine, glycine and serine increased, ubiquitination degradation of KDM4A occurred, which improved the sensitivity of gastric cancer cells to chemotherapy. Our study systematically analyzed the role and mechanism of amino acid nutrition in regulating chemotherapy sensitivity of gastric cancer, thus providing scientific basis for expanding the value of tumor nutrition therapy.
Machine Learning Methods for differentiation of Primary Central Nervous System Lymphoma and Glioma
Authors: Wang Haitao , Lu Guang , Geng Huayun , Wu Xiaoxiong , Zhang Yuxin , Zhou Wei , Mou Weiwei
Published: June 2023

Purpose and Background. Accurate differentiation of primary central nervous system lymphoma (PCNSL) and glioma on Magnetic Resonance Imaging (MRI) is an important task because the two diseases have similar imaging features, but treatment options differ vastly. This purpose of this study was to develop various machine learning methods based on radiomics features extracted from contrast-enhanced T1-weighted, T2 and the two modalities fusion to predict PCNSL and glioma types and compare the performance of different models.
Materials and Methods. A total of 82 patients from five Chinese medical centers with pathologically confirmed PCNSL and glioma were analyzed retrospectively, including 38 PCNSL and 44 glioma. Region of interest (ROI) was manually segmented on contrast-enhanced T1-weighted and T2 scans. 572 radiomics features of each patient on each modality were extracted. We explored six machine learning methods on single modality and multi-modality fusion radiomics features. The area under the receiver operating characteristic curve (AUC) and accuracy (ACC) were used to evaluate different models.
Results The cohort was split into a training (57, 70% patients) and validation cohort (25,30% patients) according to stratified sampling strategy. For the T1-weighted images,
among all models, the KNN performed best, with an accuracy of 0.947, 0.880, sensitivity of 0.885, 0.833, specificity of 1.00,0.909, and AUC of 0.993, 0.949 in the training and validation cohort, respectively. For the T2 images, among all models, the SVM performed best, with an accuracy of 0.982,0.880, sensitivity of 1.00,0.833, specificity of 0.978, 0.923, and AUC of 0.981, 0.917 in the training and validation cohort, respectively. The multi-modality fusion model achieved an accuracy of 1.000, 0.920, sensitivity of 1.00, 1.00, specificity of 1.00, 0.846, AUC of 1.00,0.994 in the training and validation cohort, which was significantly better than the single modality models.
Conclusion The established machine learning prediction models based on single or multi-modality radiomics features were feasible and achieved high performance in the PCNSL and glioma differentiation, which showed the potential to help clinical decision-making.
Signal Improved ultra-Fast Light-sheet Microscope (SIFT) for large tissue imaging
Authors: Prince Md Nasful Huda , Garcia Benjamin , Henn Cory , Yi Yating , Susaki Etsuo , Watakabe Yuki , Nemoto Tomomi , Lidke Keith A. , Zhao Hu , Remiro Irene Salinas , Liu Sheng , Chakraborty Tonmoy
Published: June 2023

Light-sheet fluorescence microscopy (LSFM) in conjunction with tissue clearing techniques enables morphological investigation of large tissues faster and with excellent optical sectioning. Recently, cleared tissue axially swept light-sheet microscope (ctASLM) demonstrated three-dimensional isotropic resolution in millimeter-scaled tissues. But ASLM based microscopes suffer from low detection signal and slow imaging speed. Here we report a simple and efficient imaging platform that employs precise control of two fixed distant light-sheet foci to carry out ASLM. This allowed us to carry out full field of view (FOV) imaging at 40 frames per second (fps) which is a four-fold improvement compared to the current state-of-the-art. In addition, in a particular frame rate, our method doubles the signal compared to the current ASLM technique. To augment the overall imaging performance, we also developed a deep learning based tissue information classifier that enables faster determination of tissue boundary. We demonstrated the performance of our imaging pipeline on various cleared tissue samples and demonstrated its robustness over a wide range of clearing protocols.
200-mm wafer scale integration of high performance polycrystalline MoS2 thin film transistors
Authors: Byun Kyung-Eun , Kwon Junyoung , Seol Minsu , Yoo Joungeun , Ryu Huije , Ko Dong-Su , Lee Min-Hyun , Yoo Min Seok , Lee Gwan-Hyoung , Shin Hyeon-Jin , Kim Jeehwan , Lee Eun-Kyu
Published: June 2023

The demand for high-performance thin-film transistors (TFTs) has increased significantly due to the increasing functionalities of electronic devices, such as displays, sensors, and computing platforms. The requirements for TFTs have also become more stringent because future electronic products necessitate denser device arrays, lower power consumption, higher mechanical flexibility, and lower-temperature processing without compromising their performance. To meet these demands, two-dimensional (2D) semiconductors are an ideal solution due to their excellent scalability, transferability, atomically thin thickness, and relatively high carrier mobility. Nevertheless, studies on 2D materials have been limited to small laboratory-scale demonstrations, focusing on proof-of-concept devices with single-crystalline 2D films. In this study, we present industrialization strategies specifically designed for polycrystalline MoS2 TFTs on a 200-mm wafer scale. We achieved nearly 100% device yield across the wafer by processing it in one of the Samsung's 200-mm fabrication facilities. We find that the metal-semiconductor junction in polycrystalline 2D MoS2 is fundamentally different from that in its single-crystalline counterpart. Thus, we redesigned the process flow to nearly eliminate the Schottky barrier height at the MoS2-metal contact, yielding excellent FET performance equivalent to that of state-of-the-art FETs fabricated from single-crystalline flakes.
A study of various factors affecting Activities of Daily Living and Instrumental Activities of Daily Living in the visually impaired
Authors: KIM Ungsoo , Heo Jung Sun , Lim Yaeji , Kim Chanho
Published: June 2023

Purpose
Visual impairment patients suffer when performing various physical activities. However, studies investigating factors affecting their practical daily activities are lacking. Therefore, we analyzed how the Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) change depending on the level of visual impairment and which factors affect the ADL and IADL of the visually impaired based on big data.
Methods
The 2020 annual report on disabled people in Korea published by the Korea Institute for Health and Social Affairs was investigated. Using 771 data samples, we evaluated the demographics, degree of visual impairment, duration of illness, various overlapping disabilities, and systemic diseases. We analyzed the effect of ADL and IADL to various factors related to visual impairment. Utilizing R statistical software, technical statistics were conducted.
Main outcomes
Association between degree of visual impairment and activities of daily living.
Results
In 2020, the total number of visually impaired people was 252,702, the third largest among registered disabled people in Korea. In terms of sex, the age groups were similar, but the percentage of visually impaired women in their 80s was about twice that of men. The more severe the visual impairment, the harder it was to perform activities of daily life except for swallowing and changing position while lying down. Differences in ADL and IADL according to age of onset of visual impairment were not significantly different except for changing position while lying down (p = 0.035). Duration of illness did not affect the ADL and IADL. The most common combined disability was hearing problems. ADL and IADL tended to worsen as patients had more chronic illnesses. In multivariate analysis, the degree of visual impairment, age of onset, and hepatitis B among systemic diseases were found to affect ADL and IADL.
Conclusions and Relevance
The degree of visual impairment and accompanying systemic diseases were significantly related components. By analyzing detailed factors related to the daily activities of the visually impaired, we can understand their lives in more detail and therefore provide more practical support.
Does Ovarian Tumor Size Predict Endometrial Cancer in Patient with Ovarian Adult Granulosa Cell Tumors?
Authors: Tokalioglu Abdurrahman Alp , Oktar Okan , Sahin Mustafa , Ozturk Cagatayhan , Erdogan Ozgur , Yildirim Hande Esra Koca , Ucar Yesim , Kilic Fatih , Ersak Burak , Yalcin Necim , Ozmen Fatma , Alci Aysun , Bas Sevda , Gorgulu Goksen , Selcuk Ilker , Ucar Gokhan , Kocak Ozgur , Cakir Caner , Kilic Cigdem , Comert Gunsu Kimyon , Ureyen Isin , Toptas Tayfun , Narin Mehmet Ali , Tasci Tolga , Taskin Salih , Boran Nurettin , Ozdal Bulent , Sanci Muzaffer , Uncu Dogan , Korkmaz Vakkas , Tekin Ozlem Moraloglu , Ustun Yaprak , Ortac Fırat , Turan Taner
Published: June 2023

Objective: The main feature of adult granulosa cell tumors (AGCT) is their capacity to secrete hormones, with nearly all of them capable of synthesizing estradiol. Endometrial pathology is caused by granulosa cell-produced estrogen exposure. The primary goal of this study is to identify endometrial pathologies, particularly the endometrial cancer, in AGCT patients who had undergone hysterectomy. The secondary objective of the study is to define the factors that predict endometrial cancer in AGCT.
Materials and Methods: The study cohort was formed with 316 AGCT patients from ten tertiary gynecological oncology centers. Surgery for AGCT consisted of bilateral salpingo-oophorectomy, hysterectomy, peritoneal cytology, omentectomy, excision of any suspicious lesion. Endometrial hyperplasia was categorized as simple hyperplasia without atypia, complex hyperplasia without atypia, complex hyperplasia with atypia or endometrial intraepithelial neoplasia (EIN). The median tumor size value was used to define the relationship between tumor size and endometrial cancer. The relationship of each value with endometrial cancer was evaluated.
Results: EIN or hyperplasia with complex atypia was detected in 7.7% of patients and endometrial cancer in 3.2% of patients. The relationship between tumor size and endometrial cancer was evaluated by taking the tumor size as a cut-off value of 150 mm. Therefore, tumor size ≤150 mm four (3.2%) and >150 mm four (12.1%) patients had endometrial cancer (p=0.036). Tumor size was statistically significant in relation to endometrial cancer in menopausal AGCT patients.
Conclusion: Our present study determined that 7.3% of patients had complex hyperplasia with atypia or EIN and 3.1% of patients had endometrial carcinoma. During the menopausal period, endometrial cancer risk was 4.5%. The study revealed that, the likelihood of developing endometrial cancer increased to 12% from %3.2 when the size of the tumor was >150 mm in menopausal patients.
Placental growth factor as a predictive marker of preeclampsia in twin pregnancy
Authors: Qi Guijie , Yao Ling , Liu Zhiming , Guo Wanru , Liu Heng , Zhang Jinghua
Published: June 2023

Background: Placental growth factor (PLGF) has been reported to predict the absence of preeclampsia (PE) in singleton pregnancies. Thus, this study aims to evaluate the predictive value of the PLGF in twin pregnancies.
Methods: Twin pregnancy with clinically suspected PE (24 weeks 0 days to 36 weeks 6 days of gestation) was enrolled in this study. The threshold of PLGF was determined on the basis of a receiver-operating characteristic curve to predict PE.
Results: A cutoff value of 215 pg/mL for PLGF indicates a good predictive performance for PE. An area under the curve of 0.863 with 86% sensitivity and 80% specificity was also obtained.
Conclusion: Effective screening for PE can be provided by the PLGF assay in twin pregnancies with clinically suspected PE.
An in vivo genome-wide CRISPR-Cas9 screen identifies FER as a tumor suppressor inhibiting the oncogenic transformation
Authors: Wang Jiaqi , Wang Fengsheng , Zhang Junlei , Dong Yutong , Wang Jiangjun , Yu Meng , Xu Yixiao , Liu Lianlian , Cheng Yuda , Yang Ran , Zhang Chen , Yang Yi , Yang Wubin , Wang Jiali , Chen Guangxing , Huang Yi , Tian Yanping , Jian Rui , Ni Bing , Wu Wei , Ruan Yan
Published: June 2023

Background
Tumorigenesis is a complex and multistep process characterized by the progressive acquisition of various hallmarks, including unlimited proliferation, resistance to apoptosis, and increased invasiveness and metastasis. However, the molecular mechanisms underlying tumorigenesis remain poorly understood.
Methods
An in vivo genome-wide CRISPR–Cas9 screen was employed to identify tumor suppressor genes (TSG). The expression correlation analysis for candidate TSGs was performed in normal and cancer cells using TCGA database. To evaluate the role of FER in tumorigenesis, we firstly used publicly single-cell RNA sequencing data to investigate the association of FER expression and normal cell malignant transformation. Next, we established FER-knockout and -knockdown models in BEAS-2B and MCF10A cell lines. Colony formation assay, cell proliferation assay, EdU assay and apoptosis assay were conducted to determine the role of FER in tumorigenesis. Then RNA-seq was performed to explore the mechanism underlying the role of FER in inhibiting tumorigenesis. Additionally, Pan-Cancer analysis was used to analysis the role of FER in tumor progression.
Results
In our CRISPR–Cas9 screen, we identified 20 candidate genes, among which FER exhibited the strongest negative correlation with tumorigenesis. Normal cells with low FER expression exhibited elevated malignant transformation potential and stemness properties. FER knockout promoted the tumorigenesis of differentiated epithelial cells by reprogramming them into a cancer stem cell (CSC)-like state, characterized by high colony-forming efficiency and suspension growth ability, increased metabolic activity, dedifferentiation properties, and immune evasion. Furthermore, tumors with low FER expression exhibited poor prognosis and a noticeable CSC-like state.
Conclusion
Taken together, our findings not only provide insights into the essential role of FER as a stemness barrier in malignant cells during tumor initiation and progression but also highlight its potential as a target for future clinical diagnosis.
Improved correlation between penetration tests and electrical resistivity
Authors: Ibanez S. J. , López-Ausín V. , Porres J. A. , Espinosa A. B. , Ortiz-Palacio S. , Garcia L. M.
Published: June 2023

A theoretical multivariate study was conducted in order to formulate an expression that relates electrical resistivity to the number of blows in the Dynamic Probing Super Heavy test. Improving further recent studies, this new expression shows a relatively good correlation between these two variables, enhanced by the multivariate analysis. It implies that robust correlations may only be drawn locally for specific field site, where the rest of the involved variables remain constant. In the search for a more general correlation, Electrical Resistivity Tomography and Dynamic Probing Super Heavy tests were performed to measure resistivity and soil resistance simultaneously at different field sites, in order to verify the results of the multivariate theoretical study. The results show that there is a qualitative relationship between these values but a quantitative relationship is only possible at the same field site, which coincides with the results of the theoretical study.
A low psoas muscle index was associated with a poorer overall survival in patients who underwent percutaneous nephrostomy
Authors: Shimokihara Kota , Kawahara Takashi , Makiyama Kazuhide , Uemura Hiroji
Published: June 2023

Introduction
Malignant ureteral obstruction (MUO) caused by urological, gynecological, and gastrointestinal cancer requires a nephrostomy or ureteral stenting to preserve the renal function and prevent pain and urinary tract infections. Recent investigations have revealed the importance of sarcopenia as a poor prognostic factor in various solid malignancies. This study investigated the importance of sarcopenia as a prognostic factor for MUO patients who have undergone nephrostomy.
Materials & Methods
A total of 89 percutaneous nephrostomies were created from July 2008 to March 2016 in our institutions. Fifty-seven of these patients had MUO. The psoas muscle volume was calculated at the L3 level using axial computed tomography images obtained prior to nephrostomy. The psoas muscle index (PMI) was calculated using the following formula: (right side psoas muscle area at the level of L3 [mm2]) / (body height [m])2.
Results
In these 57 patients, 41 cases (71.9%) were male, and 16 (28.1%) were female. The median (mean ± SD) age was 70 (69.0 ± 9.6) years old in males and 68 (66 ± 13.5) years old in females. Primary malignant diseases in MUO were urological cancers in 29 cases (50.9%), gastrointestinal cancers in 19 cases (33.3%), and gynecological cancers in 6 cases (10.5%). There were no marked differences in the OS among malignant diseases. A low PMI was associated with a poor overall survival in male MUO patients.
Conclusion
The patients who underwent percutaneous nephrostomy with sarcopenia showed a poor overall survival.
Application of the combination of CBL teaching method and SEGUE Framework to improve the doctor-patient communication skills of resident physicians in otolaryngology Department
Authors: Zeng Nan , Lu Hui , Li Shuo , Yang Qiong , Pan Hongguang , Yan Shang
Published: June 2023

Objective
To explore the feasibility and effectiveness of applying CBL teaching method and SEGUE Framework in the doctor-patient communication skills of resident physicians in the department of otolaryngology.
Methods
The score changes of doctor-patient communication skills of 120 resident physicians before and after using CBL combined SEGUE Framework teaching method were analyzed retrospectively, and the effects of gender, age, grade, educational background and marital status on SEGUE score were analyzed.
Results
Through the combined application of CBL teaching method and SEGUE Framework, the SEGUE score of 120 resident physicians was significantly improved. There was no significant difference in SEGUE score among different sex and marital status of resident physicians. SEGUE score is positively correlated with age; Different grades and educational backgrounds have significant effects on SEGUE score.
Conclusion
The combination of CBL teaching method and SEGUE Framework is feasible and effective in the teaching of doctor-patient communication skills of resident physicians in the department of otolaryngology, and worthy of popularization and application in other medical specialties.
Diffusion-induced stresses in crystals: Implications for timescales of mountain building
Authors: Hess Benjamin , Ague Jay
Published: June 2023

Intracrystalline chemical diffusion offers valuable insights into the durations of metamorphic and igneous processes. However, it can yield timescale estimates for orogenic events that are considerably shorter than those obtained via isotopic geochronology. One potential explanation for the discrepancy is that diffusion of species with different molar volumes may generate intracrystalline, compositional stresses that limit diffusional relaxation. Here, we show that compositional stress can increase the interpreted timescales of lithospheric processes by an order of magnitude or more by investigating a well-characterized garnet from the Barrovian sillimanite zone, Scotland. The garnet records sharp micrometer-scale variations in calcium and iron contents that standard diffusion treatments predict should relax in 1–10 kyr during peak thermal metamorphism. Conversely, compositional stress allows these features to persist for >100 kyr timescales, consistent with independent estimates from strontium-in-apatite tracer diffusion chronometry. Therefore, accounting for compositional stress can dramatically alter the interpretation of fundamental lithospheric processes.
Turnover behavior and intention among dentists in comparison with clinicians: A Cross- Sectional Study in China
Authors: Shi Keying , Wang Yong , Sun Zhe , Zhao Jing , Xiang Fangyue , Chen Zhi , Sun Wenjing , Zheng Yuanna
Published: June 2023

Background: Retention of doctors is a global challenge and doctors working in different departments may face different problems. The study aimed to explore the turnover behavior and intention and correlated factors among Chinese dentists compared with clinicians.
Methods: A cross-sectional study was conducted online in 5 regions of China from March 12th to April 12th, 2020. The questionnaire included 3 parts, socio-demographic characteristics, turnover behavior and intention, and concern about work-related factors. Chi-square test and/or Wilcoxon Mann-Whitney test were applied for comparison, and binary logistic regression was used for finding the factors.
Results: 2428 eligible questionnaire were received, including 1954 dentists and 474 clinicians. Rate of turnover behavior and intention was 2.87% and 51.79% among dentists, significantly lower than that among clinicians (6.96% and 71.20%, P<0.000). Compared with clinicians, dentists had significantly lower concern about workload, salary, and strained doctor-patient relationship (P<0.01), but more concern about occupational exposure (P<0.000). Educational level was a common factor of clinicians’ and dentists’ turnover behavior, while concern about salary was only for dentists. Age, concern about workload and doctor-patient relationship was common factors of clinicians’ and dentists’ turnover intention. Gender and annual household income were also correlated with dentists’ turnover intention.
Conclusions: Low turnover rate but high turnover intention rate was the current status of Chinese doctors’ employment. Turnover behavior and intention were more optimistic among dentists than clinicians. Common factors correlated with turnover behavior and intention existed among dentists and clinicians, while correlations between concern about salary, gender, annual household income and turnover only existed among dentists.
Mersilene tape versus conventional suture for preventing preterm birth in patients undergoing transvaginal cervical cerclage ： a systematic review and meta-analysis
Authors: feng Juntao , Wei Shisi , Pang Lihong
Published: June 2023

OBJECTIVE
This study aimed to evaluate the effectiveness of Mersilene tape and other suture types used in cervical cerclage procedures in prolonging singleton gestation in women at high risk of pregnancy loss due to a short cervix. The study also aimed to compare the characteristics, complications, pregnancy outcomes, and neonatal outcomes associated with the use of Mersilene tape and other suture types.
METHODS
A systematic review was conducted to identify relevant studies comparing different suture types in cervical cerclage procedures. The primary outcome of interest was preterm birth (PTB) rate. Statistical analyses were performed to determine the relationship between suture type and various outcomes.
RESULTS
A total of five studies involving 2325 participants were included in the meta-analysis. The pooled analysis indicated no significant association between suture type and PTB at less than 37 weeks of gestation (RR: 1.02, 95% CI: 0.65–1.60, p < 0.01, I2 = 74%). However, women who received Mersilene tape had a higher risk of PTB at 34–37 weeks (RR: 2.62, 95% CI: 1.57–4.37, p = 0.69, I2 = 0%), but a lower risk of PTB at less than 34 weeks (RR: 0.43, 95% CI: 0.28–0.66, p = 0.66, I2 = 46%). No statistically significant differences were observed for PTB at less than 28 weeks (RR: 1, 95% CI: 0.65–1.53, p = 0.70, I2 = 0%) and less than 24 weeks (RR: 0.86, 95% CI: 0.60–1.23, p = 0.33, I2 = 0%). Additionally, no significant differences were found in the use of Mersilene tape compared to other suture types regarding chorioamnionitis, neonatal intensive care unit (NICU) admission and neonatal death.
CONCLUSION
The findings suggest that Mersilene tape is not superior to other suture materials in terms of cerclage efficacy for high-risk women with a short cervix. However, further studies are required to validate these results and assess other outcomes, such as surgical complications and neonatal outcomes.
Bioinformatics-based screening of sepsis biomarkers
Authors: Guo Wentao , Chen Wenhao , Li Yang , Chen Muhu
Published: June 2023

Purpose
RNA-seq sequencing and bioinformatics methods were combined to identify differentially expressed genes,and Investigated new biomarkers for sepsis diagnosis and treatment.
Methods
Blood samples from 30 patients with sepsis, 10 normal volunteers, and 15 patients with systemic inflammatory response syndrome (systemic inflammatory response group) were collected in the Affiliated Hospital of Southwest Medical University for RNA-seq sequencing(TRN:ChiCTR1900021261,Date:2019.02.04).After differentiating the data, the Venn plot intersection, GO enrichment analysis, and protein interaction analysis were performed.Using the public dataset, a survival curve was constructed for the differential genes. The expression of different groups was verified as statistically significant, and then the ROC curve was constructed with sequencing data.Finally, with the help of single-cell transcriptome sequencing, the localization cell line of the core gene was identified.
Results
Comparing with the normal group, sepsis serum samples were screened for 365 differentially expressed genes: 85 were downregulated and 280 were upregulated. Compared with the systemic inflammatory response group, in the serum samples of patients with sepsis, 484 differential genes were identified.By intersection, 98 differentially expressed genes were identified, of which 184 were down-regulated and 300 were up-regulated. Among these differential genes GO function is enriched in specific granules, tertiary granules and specific granule cavities. CEBPE, IL1R2, CYSTM1, S100A9, FCER1A, MCEMP1, NELL2, SERPINB10 were found in the center of the protein interaction network analysis.Based on RNA-sequencing data, CEBPE was highly expressed in the sepsis group and NELL2 was low in the group.The survival curve showed that the lower the CEBPE expression in patients with sepsis, the higher the NELL2 expression and the higher the survival rate. Based on the ROC curves, CEBPE had an AUC of 0.920 (normal), 0.882 (systemic inflammatory response group), while NELL2 had an AUC of 0.960(normal), 0.844 (systemic inflammatory response group).In single-cell sequencing, CEBPE was mainly found in macrophage cells and NELL2 was found in T cells.
Conclusion
CEBPE expression in macrophages is positively correlated with sepsis mortality. NELL2 expression in T cell lines is positively correlated with survival rates in sepsis patients.Both have good diagnostic value, or they can be used as new research targets.
Association between dietary protein intake and depression in American adults with metabolic syndrome
Authors: Gu Xue , Shen Xia , Liu Yuan-Yuan , Chu Jiang-Hui , Jiang Lei
Published: June 2023

Background
There is currently intense interest in the effects of macronutrients on mental disorders. The purpose of the study was to analyze the relationship between depression and protein intake in people with metabolic syndrome.
Methods
The study analyzed data on 7922 individuals with metabolic syndrome that were derived from the National Health and Nutrition Examination Survey (NHANES)1999–2018. To test whether the investigated variables differed significantly, variance and the chi-squared test were used to analyze dietary protein intake among groups. Variables with significant differences were selected for multiple logistic regression analysis to further explore the associations between PHQ-9 defined depressive symptoms and protein. Smoothed curve fitting was employed to determine whether if there was a nonlinear correlation between the two.
Results
As protein eaten increased, the number of participants suffering from depression decreased. After adjusting for confounding variables (eGFR, cancer, thyroid disease, total energy, carbohydrate, fiber, calcium, caffeine intake, magnesium, and general information), multivariate logistic regression analysis indicated that dietary protein may serve as a protective factor for depression. Moreover, a negative nonlinear association between depression and dietary protein was found.
Conclusion
These findings indicate that for individuals with metabolic syndrome dietary protein is relevant to depression.
Estimating the Stage-Discharge Relationship at the Confluence of Ungauged Streams: A Hydrological Modeling Approach
Authors: Saha Probal
Published: June 2023

Understanding flow patterns and developing a stage-discharge relationship is essential for effectively managing and protecting water resources in watersheds. Evidence of streambank erosion at confluences due to high peak flows further highlights the urgency of implementing sustainable management strategies. However, the unavailability of discharge data for sub-watersheds necessitates the use of modeling techniques. This study employed a three-layered Hydrological model VIC to estimate the stage-discharge relationship and analyze flow dynamics. Beaver Creek, a tributary of the Clinch River, and Cox Creek, situated in Knox County, Tennessee, experience seasonal flow fluctuations and sedimentation, which pose significant challenges to stream sustainability. To validate the VIC model, downstream USGS stations were selected to compare model output flow. The VIC model incorporated vegetation, soil, and climate inputs and was calibrated using the efficient Shuffled Complex Evolution Algorithm. The final model outputs demonstrated high performance, with a Nash Sutcliffe efficiency of 0.90 and a linear correlation exceeding 0.87 compared to the USGS downstream stations. The daily fluxes accurately captured flow peaks, demonstrating the model's efficacy. Additionally, the derived stage-discharge relationship provided a power equation with a correlation of 0.76, facilitating further research and analysis. The outcomes of this study hold significant implications for future hydrodynamic modeling efforts, allowing for the observation of flood inundation and wall shear stress at the confluence of Beaver-Cox Creeks.
Ecotype maintenance in Callicarpa subpubescens via local environmental adaptation amidst frequent hybridization and low pre- and post-mating barriers
Authors: Setsuko Suzuki , Sugai Kyoko , Tamaki Ichiro , Hayama Kayo , Kato Hidetoshi
Published: June 2023

Adaptive radiations frequently occur on oceanic islands, but the mechanisms behind the maintenance of species and ecotypes after such radiations remain poorly understood, especially regarding potential gene flow among sympatric congeners. Callicarpa subpubescens is endemic to the oceanic Ogasawara Islands, and it has been suggested that multiple ecotypes exist within the southern part of this group, the Hahajima Islands, each associated with a unique localized habitat. Here, we determined the habitat characteristics of each ecotype and the degree of pre- and post-mating isolation by investigating flowering time overlap cross compatibility, and gene flow among ecotypes using an EST-SSR marker analysis of adult trees and naturally pollinated seeds. Our study confirmed the presence of four distinct ecotypes on the Hahajima Islands, with one likely arising from hybridization. Each ecotype was confined to specific island habitats, and distinct leaf morphologies and plant heights suggested local adaptation. However, overlapping flowering times and successful artificial cross pollination indicated little pre- and post-mating isolation. Hybridization rates in adult trees and naturally pollinated seeds were 37.2% and 26.4%, respectively, and most hybrids were backcrosses with few first- or second-generation hybrids. The hybridization rates of each ecotype and paternal correlation indicated that the flowering synchrony and close spatial distribution of ecotypes contributed to hybridization among ecotypes. Overall, C. subpubescens likely maintains four distinct ecotypes in spite of frequent hybridization probably due to selection pressures that result in reversion to the original ecotype via backcrossing, since this is well-adapted to the local environment.
Compressed Domain Human Fall Detection using Deep Features
Authors: Darvish Mahta , Mansouri Azadeh
Published: June 2023

Falling is one of the most dangerous events that can happen to an adult and can lead to chronic injuries. These damages and adverse effects of falling can be reduced with quick diagnosis and treatment. So far, two general approaches have been introduced for fall detection: sensor-and camera-based which the latter is our approach in this work. After a camera has acquired environmental data, we do some processing on the data to extract the necessary features. Following this, it is the turn of a classifier to tell a falling input from a non-falling one. In this thesis, in addition to reporting the results in the raw mode of the samples in the used datasets, we also present the results in the compressed mode because of the lower complexity and greater applicability of data in compressed form.
Fine-Tuning Buffalo-Veal Meat Slices: The Impact of Particle Size, Fat Content, and Tumbling Time and their Interplay Through Principal Component Analysis
Authors: Singh Pradeep Kumar , Jairath Gauri , Yadav Sanjay , Pathera Ashok Kumar , Ahlawat Satyavir Singh , Sharma Diwakar Prakash
Published: June 2023

Buffalo veal can contribute to the food sustainability to a great extent, but has restricted palatability due to poor marbling at young age. Thus, with an objective to explore the potential of buffalo veal to develop ready-to-eat processed product as an alternative to that prepared from spent animals, especially in India, the study was planned to optimize the particle size, fat level and tumbling time to develop ground meat slices. The objective of particle size and fat level optimization was to improve the meat feel and that of tumbling was to improve binding without affecting the particle size. The product was compared for different quality attributes and interplay of different variables were analyzed through principal component analysis (PCA). The results revealed significantly (P≤0.05) higher ES, WHC, cooking yield, lower dimensional changes, improved slice-ability and fold test were observed in the products developed with 3 mm particle size, 10 per cent fat and 1 hour tumbling time. PCA revealed the association of fat with higher TBA values, dimensional changes (diameter and height) and fat level in the product. The textural parameters were more favorable with smaller particle size and 10% fat level. The study revealed the close association of tumbling with the most of the processing and quality attributes. However, the instrumental color was at par, irrespective of variables except b* value in 10% fat level. The study concluded that buffalo veal slices of improved quality could be prepared at 3mm particle size,10 % fat level and 1 hour tumbling time.
LPCAT1-mediated membrane phospholipid remodeling promotes ferroptosis evasion and tumor growth
Authors: Li Jun , Li Ziwen , Hu Yameng , Zheng Haiqing , Li Man , Feng Rongni , Yang Meisongzhu , Li Xincheng , Zhang Shuxia , Tang Miaoling , xu yingru , Yu Ruyuan , Chen Suwen , Qian Wanying , liao Xinyi , Zhang Qiliang , Li Bo , Song Libing
Published: June 2023

The mechanisms underlying how cells dynamically remodel membrane phospholipids to prevent phospholipid peroxidation-induced membrane damage and evade ferroptosis, which maintains the physiological function of cellular processes and cell survival, remain unclear. Herein, we reported that lysophosphatidylcholine acyltransferase 1 (LPCAT1) played a critical role in ferroptosis resistance by increasing membrane phospholipid saturation via the Land’s cycle, consequently reducing membrane levels of polyunsaturated fatty acids, protecting cells from phospholipid peroxidation-induced membrane damage, and inhibiting ferroptosis. Furthermore, we found that tumor cells that were initially unable to colonize the subcutis formed large tumor nodules after latency was closely associated with the upregulation of LPCAT1 expression and the emergence of a ferroptosis-resistant state. Combining LPCAT1 inhibition with a ferroptosis inducer synergistically induced ferroptosis and suppressed tumor growth. Therefore, our results unveil a plausible role for LPCAT1 in ferroptosis evasion and may represent a new target for clinical intervention in human cancer.