bluuebunny/crossref_metadata_2025 huggingface dataset:
Prognostic Implications of Early Albuminocytological Dissociation in Guillain–Barré Syndrome
Authors: Vargas-Cañas Edwin Steven , Galnares-Olalde Javier Andrés , León-Velasco Fausto , García-Grimshaw Miguel , Gutiérrez Alonso , López-Hernández Juan Carlos
Published: August 2022

Background:

Half of Guillain–Barré syndrome (GBS) present elevated cerebrospinal fluid (CSF) protein levels within 1 week since symptom onset and 80% within 2 weeks. Our objective was to determine the clinical and prognostic implication of albuminocytological dissociation in early GBS.

Methods:

An ambispective cohort study was conducted. Good outcome was considered if the patient was able to walk unaided (Guillain-Barré disability score [GDS] ≤ 2 points) at 3-month follow-up. Patients were classified into two groups: with and without albuminocytological dissociation; we compared clinical and paraclinic characteristics between the groups. We analyzed clinical and electrophysiological factors related to presenting early dissociation through a multivariate model.

Results:

We included 240 patients who fulfilled Asbury criteria for GBS. On further selection, only 94 patients fulfilled inclusion. Mean age was 45.94 ± 17.1 years and 67% were male. Median time from symptom onset to admission was 5 days (IQR 3–6). Regarding albuminocytological dissociation and electrophysiological variants, we found a significant difference: acute inflammatory demyelinating polyneuropathy (AIDP) [60.6% vs 26.2%,p= 0.002], acute motor axonal neuropathy (AMAN) [21.2% vs 49.1%,p= 0.009] and acute motor sensory axonal neuropathy (AMSAN) [12.1% vs 1.6%,p= 0.05]. We did not observe significant differences in recovery of independent walking in short term between both groups. The presence of conduction block in any variant (OR 3.21, 95% CI 1.12–9.16,p= 0.02) and absence of sural registration (OR 5.69, 95% CI 1.48–21.83,p= 0.011) were independent factors related to early dissociation.

Conclusions:

Early dissociation (<7 days) is not associated with any particular clinical feature or unfavorable outcome. It is more common to see in AIDP rather than axonal variants.
Developing an engaging and accessible clinical research training program for new investigators
Authors: Markman Kris M. , Brewer Sarah K. , Klein Andreas K. , Magnuson Britta
Published: August 2022

Clinicians who are interested in becoming principal investigators struggle to find and complete training that adequately prepares them to conduct safe, well-designed clinical and translational research. Degree programs covering these skills require a significant time investment, while online trainings lack engagement and may not be specific to local research contexts. Staff at Tufts Clinical and Translational Science Institute sought to fill the gap in junior investigator training by designing an eight-module, noncredit certificate program to teach aspiring clinician-investigators about good clinical practice, clinical research processes, and federal and local regulatory requirements. The first iteration of this program was evaluated using pre- and posttest questionnaires and by gathering clinician learner feedback in a focus group. Based on the pre- and posttest questionnaires, learners experienced an increase in self-efficacy and confidence related to clinical research competencies. Feedback from learners also highlighted important program strengths, including an engaging program format, a manageable time commitment, and an emphasis on identifying crucial research resources. This article describes one approach to creating a meaningful and efficient clinical trial training program for clinicians.
Mental health implications on Afghan children: an impending catastrophe
Authors: Qamar Khulud , Priya  , Rija Aiman , Vohra Laiba Imran , Nawaz Faisal A. , Essar Mohammad Yasir
Published: August 2022

Afghan children have suffered for decades because of chronic socioeconomic health crises. The current state of Afghanistan has deprived the basic human needs of children. The lack of freedom leaves their voices unheard, causing detrimental effects on their mental health. Mental illnesses such as post-traumatic stress disorder, anxiety, and depression are prevalent in Afghanistan, causing severe negative outcomes among children. Promotion of mental health services, psychological training, awareness campaigns, acceptance of Afghan refugees, and initiatives to support re-connecting with loved ones, are among the many recommended measures needed to manage this alarming situation. This requires an immediate action plan from government and public health officials to mitigate this impending catastrophe.
Impact of genetic deletion of MrgD or Mas receptors in depressive-like behaviour in mice
Authors: Becari Luca , Fonseca Maria Luiza A. , Gonçalves Sthéfanie C. A. , Bader Michael , Santos Robson A. S. , Campagnole-Santos Maria José , Kangussu Lucas M.
Published: August 2022

Objectives:

To evaluate the impact of genetic deletion of receptors of the counterregulatory arms of the renin–angiotensin system in depressive-like behaviours.

Methods:

8–12 weeks-old male mice wild type (WT, C57BL/6J) and mice with genetic deletion of MrgD (MrgD KO) or Mas receptors (Mas KO) were subjected to the Forced Swim Test (FST) and the Tail Suspension Test (TST). Brain-derived neurotrophic factor (BDNF) levels were measured by enzyme-linked immunosorbent assay (ELISA). Blockade of Mas was performed by acute intracerebroventricular (icv) injection of its selective antagonist, A779.

Results:

No statistical difference in immobility time was observed between MrgD KO and WT male animals subjected to FST and TST. However, acute icv injection of A779 significantly increased the immobility time of MrgD KO male mice subjected to FST and TST, suggesting the involvement of Mas in preventing depressive-like behaviour. Indeed, Mas KO male animals showed increased immobility time in FST and TST, evidencing a depressive-like behaviour in these animals, in addition to a reduction in BDNF levels in the prefrontal cortex and hippocampus. No changes in BDNF levels were observed in MrgD KO male animals.

Conclusion:

Our data showed that Mas plays an important role in the neurobiology of depression probably by modulating BDNF expression. On the contrary, lack of MrgD did not alter depressive-like behaviour, which was supported by the lack of alterations in BDNF levels.
Effect of live yeast supplementation and feeding frequency in male finishing pigs subjected to heat stress
Authors: Serviento Aira Maye , Castex Mathieu , Renaudeau David , Labussière Etienne
Published: August 2022

In growing pigs, reduced growth during heat stress (HS) is mainly related to decreased feed intake. The study aimed to determine whether the reported positive effects of live yeast (LY) supplementation in HS pigs were due to a modified feeding behaviour or energy metabolism, and if these can be replicated by imposing an increased meal frequency. The effect of LY supplementation (0 (NS) v. 100 (LY) g/ton of feed), and of feeding window (FW) (unlimited or Unli, 2FW of 1 h each and 8FW of 15 min each) were measured in entire male finishing pigs (n 36). Ambient temperature was at 22°C during the thermoneutral (TN) period (5 d) and at 28°C during the HS period (5 d). Heat exposure decreased DM intake (DMI) and retained energy (RE) (–627 and −460 kJ·kg BW–0·60 · d–1, respectively; P < 0·01). During HS, LY supplementation in Unli pigs decreased inter-meal intervals (P = 0·02) attenuating HS effect on DMI which tended to improve RE (P = 0·09). NS – 8FW had higher DMI and RE than NS – 2FW (P < 0·05) but protein deposition (PD) were similar. Supplemented pigs had higher PD during HS regardless of FW (+18 g · d–1; P = 0·03). Comparing the 2FW groups, improved heat tolerance of LY-supplemented pigs were due to improved insulin sensitivity (P < 0·05) and latent heat loss capacity after a meal (P < 0·05) allowing them to increase their DMI (via an increased number of meals) and thus their energy efficiency. Imposing an increased meal frequency improved DMI in HS pigs but did not replicate positive effects of LY on PD.
The impact of pasture and non-pasture diets on the sensory and volatile properties of whole milk powder
Authors: Cheng Zeng , Mannion David T. , O'Sullivan Maurice G. , Miao Song , Kerry Joseph P. , Kilcawley Kieran N.
Published: August 2022

This study evaluated the impact of three distinct diets; perennial ryegrass (GRS), perennial ryegrass/white clover (CLV) and total mixed ration (TMR), on the sensory properties and volatile profile of whole milk powder (WMP). The samples were evaluated using a hedonic sensory acceptance test (n = 99 consumers) and by optimised descriptive profiling (ODP) using trained assessors (n = 33). Volatile profiling was achieved by gas chromatography mass spectrometry using three different extraction techniques; headspace solid phase micro-extraction, thermal desorption and high capacity sorptive extraction. Significant differences were evident in both sensory perception and the volatile profiles of the WMP based on the diet, with WMP from GRS and CLV more similar than WMP from TMR. Consumers scored WMP from CLV diets highest for overall acceptability, flavour and quality, and WMP from TMR diets highest for cooked flavour and aftertaste. ODP analysis found that WMP from TMR diets had greater caramelised flavour, sweet aroma and sweet taste, and that WMP from GRS diets had greater cooked aroma and cooked flavour, with WMP derived from CLV diets having greater scores for liking of colour and creamy aroma. Sixty four VOCs were identified, twenty six were found to vary significantly based on diet and seventeen of these were derived from fatty acids; lactones, alcohols, aldehydes, ketones and esters. The abundance of δ-decalactone and δ-dodecalactone was very high in WMP derived from CLV and GRS diets as was γ-dodecalactone derived from a TMR diet. These lactones appeared to influence sweet, creamy, and caramelised attributes in the resultant WMP samples. The differences in these VOC derived from lipids due to diet are probably further exacerbated by the thermal treatments used in WMP manufacture.
Cochlear implantation in a profoundly deaf child with cystic leukoencephalopathy without megalencephaly
Authors: Gopalakrishnan A , Thangavel S , Chowdhary S , Alexander A
Published: August 2022

Background

Cochlear implantation candidacy criteria have continued to evolve over the years, and cochlear implantation is possible with many inner-ear and brain anomalies with good hearing and linguistic outcomes. Cystic leukoencephalopathy without megalencephaly is a rare disease in children, with only 30 cases reported in the literature, but it is associated with hearing loss in only three cases. Radiological investigations can help in diagnosing this rare entity before proceeding with cochlear implantation.

Case Report

A four-year-old female child born out of consanguinity with normal psychomotor development, bilateral sensorineural hearing loss and an incidental magnetic resonance imaging finding of cystic leukoencephalopathy without megalencephaly underwent successful cochlear implantation. Her post-operative period was uneventful with successful mapping of the cochlear implant.

Conclusion

This is the first reported case of cystic leukoencephalopathy without megalencephaly and with sensorineural hearing loss in which cochlear implantation was performed successfully. White matter and temporal lobe abnormalities should not deter paediatric cochlear implantation.
The relevance of selenium to viral disease with special reference to SARS-CoV-2 and COVID-19
Authors: Rayman Margaret P. , Taylor Ethan Will , Zhang Jinsong
Published: August 2022

In this review, the relevance of selenium (Se) to viral disease will be discussed paying particular attention to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease (COVID-19). Se, the active centre in selenoproteins has an ongoing history of reducing the incidence and severity of viral infections. Host Se deficiency increased the virulence of RNA viruses such as influenza A and coxsackievirus B3, the latter of which is implicated in the development of Keshan disease in north-east China. Significant clinical benefits of Se supplementation have been demonstrated in HIV-1, in liver cancer linked to hepatitis B, and in Chinese patients with hantavirus that was successfully treated with oral sodium selenite. China is of particular interest because it has populations that have both the lowest and the highest Se status in the world. We found a significant association between COVID-19 cure rate and background Se status in Chinese cities; the cure rate continued to rise beyond the Se intake required to optimise selenoproteins, suggesting an additional mechanism. Se status was significantly higher in serum samples from surviving than non-surviving COVID-19 patients. As regards mechanism, SARS-CoV-2 may interfere with the human selenoprotein system; selenoproteins are important in scavenging reactive oxygen species, controlling immunity, reducing inflammation, ferroptosis and endoplasmic reticulum (ER) stress. We found that SARS-CoV-2 significantly suppressed mRNA expression of GPX4, of the ER selenoproteins, SELENOF, SELENOM, SELENOK and SELENOS and down-regulated TXNRD3. Based on the available data, both selenoproteins and redox-active Se species (mimicking ebselen, an inhibitor of the main SARS-CoV-2 protease that enables viral maturation within the host) could employ their separate mechanisms to attenuate virus-triggered oxidative stress, excessive inflammatory responses and immune-system dysfunction, thus improving the outcome of SARS-CoV-2 infection.
Neurobiological sensitivity to unpredictable threat and familial risk for the internalizing and externalizing spectra in adolescents
Authors: Beatty Clare C. , Ferry Rachel A. , Eaton Nicholas R. , Klein Daniel N. , Nelson Brady D.
Published: August 2022

Background

Adolescence is a key developmental period for the emergence of psychiatric disorders. However, there is still no consensus on the core mechanisms of dysfunction in youth. Neurobiological sensitivity to unpredictable threat has been associated with several psychiatric disorders in adults. The present study examined adolescent defensive motivation (startle reflex) and attention (event-related potentials) in anticipation of unpredictable threat in relation to both adolescent and maternal (i.e. familial risk) internalizing and externalizing spectra.

Methods

The sample included 395 15-year-old adolescents and their biological mothers. Adolescent startle potentiation and probe P300 suppression (indicating increased attention to threat) were measured in anticipation of predictable and unpredictable threat. Adolescent and maternal lifetime history of psychiatric disorders were assessed via semi-structured diagnostic interviews, and confirmatory factor analysis was used to model internalizing and externalizing spectra.

Results

The adolescent internalizing spectrum was positively associated with adolescent startle potentiation and probe P300 suppression to unpredictable threat. Conversely, the adolescent externalizing spectrum was negatively associated with adolescent P300 suppression to unpredictable threat. The maternal internalizing spectrum was positively associated with adolescent startle potentiation to unpredictable threat and P300 suppression to both predictable and unpredictable threat. The maternal externalizing spectrum was negatively associated with adolescent startle potentiation to unpredictable threat and P300 suppression to both predictable and unpredictable threat. Adolescent and maternal internalizing and externalizing spectra were independently related to adolescent startle potentiation and P300 suppression.

Conclusions

Adolescent neurobiological sensitivity to unpredictable threat is associated with both personal history and familial risk for the internalizing and externalizing spectra.
Revisiting Bavinck on Hegel: Providence, reason, and the unsublatable
Authors: Tseng Shao Kai , Sutanto Nathaniel Gray
Published: August 2022

Herman Bavinck's reception of the organic motif has become in recent years the central locus for discussing the means by which the unity of his thought may be recognised. This article provides a critical reading of Bavinck on Hegel on the locus of providence for the purpose of contributing to the ongoing discussion that identifies the unity of Bavinck's thought not in his confessional self in simple opposition against the philosophies of his day, but rather in characterising Bavinck as an eclectic, orthodox and modern theologian. To this end this essay moves in three steps. First, we provide an analysis that showcases the nuanced points of contact between Bavinck and Hegel on providence. Second, the essay homes in on the specific ways in which the two thinkers diverge on the Creator–creature relationship. Finally, we close the essay by sketching the salient dogmatic and philosophical implications of the preceding analysis.
Prevalence and demographic correlates of online grocery shopping: results from a nationally representative survey during the COVID-19 pandemic
Authors: Duffy Emily W , Lo Amy , Hall Marissa G , Taillie Lindsey Smith , Ng Shu Wen
Published: August 2022

Objective:

To estimate the prevalence of online grocery shopping in a nationally representative sample and describe demographic correlates with online grocery shopping.

Design:

The Nielsen COVID-19 Shopper Behavior Survey was administered to a subset of Nielsen National Consumer Panel participants in July 2020. We used survey weighted-multivariable logistic regression to examine demographic correlates of having ever online grocery shopped.

Setting:

Online survey.

Participants:

18 598 Nielsen National Consumer Panel participants in the USA.

Results:

Thirty-nine percent of respondents had purchased groceries online, and among prior purchasers, 89 % indicated that they would continue to online grocery shop in the next month. Canned/packaged foods were the most shopped for grocery category online, followed by beverages, fresh foods and lastly frozen foods. In adjusted analyses, younger respondents (39 years or less) were more likely (47 %) to have ever shopped for groceries online than older age groups (40–54 years, 55–64 years and 65+ years) (29 %, 22 % and 23 %, respectively, all P < 0·001). Those with greater than a college degree were more likely to have ever grocery shopped online (45 %) than respondents with some college education (39 %) and with a high school education or less (32 %) (both P < 0·001). Having children, having a higher income and experiencing food insecurity, particularly among higher income food-insecure households, were also associated with a higher probability of prior online grocery shopping.

Conclusions:

The COVID-19 pandemic accelerated the transition to online grocery shopping. Future research should explore the nutrition implications of online grocery shopping.
Digitized thought records: a practitioner-focused review of cognitive restructuring apps
Authors: Erhardt Drew , Bunyi John , Dodge-Rice Zoë , Neary Martha , Schueller Stephen M.
Published: August 2022

Mental health (MH) apps can be used as adjunctive tools in traditional face-to-face therapy to help implement components of evidence-based treatments. However, practitioners interested in using MH apps face a variety of challenges, including knowing which apps would be appropriate to use. Although some resources are available to help practitioners identify apps, granular analyses of how faithfully specific clinical skills are represented in apps are lacking. This study aimed to conduct a review and analysis of MH apps containing a core component of cognitive behaviour therapy (CBT) – cognitive restructuring (CR). A keyword search for apps providing CR functionality on the Apple App and Android Google Play stores yielded 246 apps after removal of duplicates, which was further reduced to 15 apps following verification of a CR component and application of other inclusionary/exclusionary criteria. Apps were coded based on their inclusion of core elements of CR, and general app features including app content, interoperability/data sharing, professional involvement, ethics, and data safeguards. They were also rated on user experience as assessed by the Mobile App Rating Scale (MARS). Whereas a majority of the CR apps include most core CR elements, they vary considerably with respect to more granular sub-elements of CR (e.g. rating the intensity of emotions), other general app features, and user experience (average MARS = 3.53, range from 2.30 to 4.58). Specific apps that fared best with respect to CR fidelity and user experience dimensions are highlighted, and implications of findings for clinicians, researchers and app developers are discussed.

Key learning aims

(1)

To identify no-cost mobile health apps that practitioners can adopt to facilitate cognitive restructuring.

(2)

To review how well the core elements of cognitive restructuring are represented in these apps.

(3)

To characterize these apps with respect to their user experience and additional features.

(4)

To provide examples of high-quality apps that represent cognitive restructuring with fidelity and facilitate its clinical implementation.
Behandlung des Hallux valgus
Authors: Schmeichel Steffen , Krähenbühl Nicola
Published: August 2022

Zusammenfassung. Die Hallux-valgus-Deformität ist eine häufige Deformität des Fusses und beinhaltet eine Valgusdeviation sowie Pronation des Grosszehens mit prominentem Metatarsophalangeal(MTP)-I-Gelenk (Pseudoexostose). Ist klinisch die Problematik einer Hallux-valgus-Deformität evident, sollten zur weiteren Abklärung standardisierte Röntgenbilder des Fusses durchgeführt werden. Wenige radiologische Parameter reichen dabei aus, um konventionelle Röntgenbilder in der hausärztlichen Praxis adäquat beurteilen zu können. Nach erfolgter Diagnostik kann in den meisten Fällen die Etablierung einer konservativen Therapie durch den Grundversorger erfolgen (z.B. Schuheinlagen). Sollte eine chirurgische Therapie nötig sein, so ist eine Vielzahl verschiedener Techniken beschrieben. Grundsätzlich sind die zu erwartenden Ergebnisse nach operativer Therapie erfreulich und die Komplikationsrate vergleichsweise niedrig.
Evaluation of a System for Real-Time Surveillance of Suicide in England
Authors: Doyle Michael , Ainsworth Philip , Boul Sarah , Lee Diane
Published: August 2022

Abstract. Background: Access to timely data on suicide is crucial to support suicide prevention. A real-time suicide surveillance (RTSS) system enables public health teams and allied agencies to review information following suicides promptly and take action quickly. Aims: The aim of this paper was to report on an evaluation of an RTSS system in South Yorkshire, England. Method: The system was reviewed, and outcome data were analyzed for 2019 and 2020 based on recorded suspected suicides, a stakeholder focus group, evaluation of postvention bereavement service outcomes, and lessons learned. Results: The benefits of RTSS included rapid response to emerging trends, identifying clusters, effective bereavement support, information to inform measures to mitigate risk, and supporting evaluation of interventions. The challenges faced included limited resources, data quality, consistency across places, and linkages with coronial processes. Limitations: This was an evaluation of one RTSS system based on routinely collected data covering one area, South Yorkshire, and hence some data limitations, and direct comparison with other services or against a control group was not possible. Conclusion: The RTSS system has led to better support for suicidal people and a responsive, timely, and effective service for those bereaved by suicide, all of which are likely to lead to enhanced well-being and community resilience.
Quantifying Northern High Latitude Gross Primary Productivity (GPP) Using Carbonyl Sulfide (OCS)
Authors: Kuai Le , Parazoo Nicholas C. , Shi Mingjie , Miller Charles E. , Baker Ian , Bloom Anthony A. , Bowman Kevin , Lee Meemong , Zeng Zhao‐Cheng , Commane Roisin , Montzka Stephen A. , Berry Joe , Sweeney Colm , Miller John B. , Yung Yuk L.
Published: August 2022

The northern high latitude (NHL, 40°N to 90°N) is where the second peak region of gross primary productivity (GPP) other than the tropics. The summer NHL GPP is about 80% of the tropical peak, but both regions are still highly uncertain (Norton et al. 2019, https://doi.org/10.5194/bg-16-3069-2019). Carbonyl sulfide (OCS) provides an important proxy for photosynthetic carbon uptake. Here we optimize the OCS plant uptake fluxes across the NHL by fitting atmospheric concentration simulation with the GEOS‐CHEM global transport model to the aircraft profiles acquired over Alaska during NASA's Carbon in Arctic Reservoirs Vulnerability Experiment (2012–2015). We use the empirical biome‐specific linear relationship between OCS plant uptake flux and GPP to derive the six plant uptake OCS fluxes from different GPP data. Such GPP‐based fluxes are used to drive the concentration simulations. We evaluate the simulations against the independent observations at two ground sites of Alaska. The optimized OCS fluxes suggest the NHL plant uptake OCS flux of −247 Gg S year−1, about 25% stronger than the ensemble mean of the six GPP‐based OCS fluxes. GPP‐based OCS fluxes systematically underestimate the peak growing season across the NHL, while a subset of models predict early start of season in Alaska, consistent with previous studies of net ecosystem exchange. The OCS optimized GPP of 34 PgC yr−1 for NHL is also about 25% more than the ensembles mean from six GPP data. Further work is needed to fully understand the environmental and biotic drivers and quantify their rate of photosynthetic carbon uptake in Arctic ecosystems.
Spatial and Temporal Variability of Atlantic Water in the Arctic From 40 Years of Observations
Authors: Richards Alice E. , Johnson Helen L. , Lique Camille
Published: August 2022

Atlantic Water (AW) is the largest reservoir of heat in the Arctic Ocean, isolated from the surface and sea ice by a strong halocline. In recent years, AW shoaling and warming are thought to have had an increased influence on sea ice in the Eurasian Basin. In this study, we analyze 59,000 profiles from across the Arctic from the 1970s to 2018 to obtain an observationally based pan‐Arctic picture of the AW layer, and to quantify temporal and spatial changes. The potential temperature maximum of the AW (the AW core) is found to be an easily detectable, and generally effective metric for assessments of AW properties, although temporal trends in AW core properties do not always reflect those of the entire AW layer. The AW core cools and freshens along the AW advection pathway as the AW loses heat and salt through vertical mixing at its upper bound, as well as via likely interaction with cascading shelf flows. In contrast to the Eurasian Basin, where the AW warms (by approximately 0.7°C between 2002 and 2018) in a pulse‐like fashion and has an increased influence on upper ocean heat content, AW in the Canadian Basin cools (by approximately 0.1°C between 2008 and 2018) and becomes more isolated from the surface due to the intensification of the Beaufort Gyre. These opposing AW trends in the Eurasian and Canadian Basins of the Arctic over the last 40 years suggest that AW in these two regions may evolve differently over the coming decades.
Alteration at the Base of the Siccar Point Unconformity and Further Evidence for an Alkaline Provenance at Gale Crater: Exploration of the Mount Sharp Group, Greenheugh Pediment Cap Rock Contact With APXS
Authors: Thompson L. M. , Spray J. G. , O’Connell‐Cooper C. , Berger J. A. , Yen A. , Gellert R. , Boyd N. , McCraig M. A. , VanBommel S. J.
Published: August 2022

Chemical data acquired by Curiosity's Alpha Particle X‐ray Spectrometer during examination of the contact between the upper Mount Sharp group and overlying Stimson formation sandstones at the Greenheugh pediment reveal compositional similarities to rocks encountered earlier in the mission. Mount Sharp group strata encountered below the Basal Siccar Point group unconformity at the base and top of the section, separated by >300 m in elevation, have distinct and related compositions. This indicates enhanced post‐depositional fluid flow and alteration focused along this contact. Sandstone targets exposed immediately above the unconformity have basaltic compositions consistent with previously encountered eolian Stimson formation sandstones, except at the contact, where they show the addition of S. Resistant sandstone outcrops above the contact have higher K, Mn, and Na and lower Ni concentrations that primarily reflect changes in provenance. They are compositionally related to cap rock float blocks encountered as Curiosity climbed through the Mount Sharp group, and Bradbury group sandstone outcrops. The higher K, pediment sandstones are interpreted to have a similar provenance to some Bradbury group sandstones, further evidence for widespread, alkaline source rock within and/or in the vicinity of Gale crater. The Bradbury and Siccar Point groups may both be younger than the Mount Sharp group. Alternatively, an alkaline source area in and around Gale crater has been eroded by both water and wind at different times (both before and after deposition of the Mount Sharp group), during the evolution of the crater and its infill.
Exploring the Impact of Landscape Ecological Risk on Water Quality in the Danjiangkou Reservoir, China
Authors: Cao Zhenxiu , Wan Bo , Xiao Yuhuang , Wu Minghui , Tan Xiang , Zhang Quanfa , Wang Dezhi
Published: August 2022

Evaluating the spatial‐temporal dynamics in ecological risk and understanding its impact on water quality in reservoirs could optimize watershed land use and protect reservoir water quality. However, this impact remains elusive due to the lack of long‐term field data, the heterogeneity of land use, and scale effects. Therefore, Danjiangkou Reservoir area was selected as the study area, where rapid urban expansion and ecological conservation and restoration measures have significantly changed the ecological environment, altering the water quality. We investigated the spatial‐temporal changes of land use from 1990 to 2020 and evaluated how landscape ecological risk changed, as well as explored the impact of landscape ecological risk changes on water quality. The landscape ecological risk was calculated by landscape vulnerability and landscape disturbance (based on fragmentation, separation, and fractal dimension). The results indicated that the growth rate of water bodies surged (7.65 km2/a) and cropland experienced an apparent reduction (14.39%) over the past 30 years. These landscape changes decreased ecological risk, especially after the water transfer. The results revealed that the impacts of ecological risk on water quality were better explained at the riparian scale than at the reach and catchment scales. Specifically, the ecological risk was strongly relevant to dissolved oxygen, Turbidity, Cl− and , and moderately correlated to Ca2+ and pH. While it was not correlated with total nitrogen, total phosphorus, and F−, possibly due to the irregular reservoir operations, occasional excessive use of fertilizers, and rock weathering. This study preliminarily discloses the impact of landscape ecological risk on water quality in a basin reservoir and provides a theoretical basis to take measures in advance for the sustainable development of a reservoir basin.
Seeing Through Turbulence to Track Oil Spills in the Ocean
Authors: Garc�a-S�nchez Guillermo , Mancho Ana , Ramos Antonio , Coca Josep , Wiggins Stephen
Published: August 2022

After oil and tar washed up on eastern Mediterranean beaches in 2021, scientists devised a way to trace the pollution back to its sources using satellite imagery and mathematics.
Large‐Scale Traveling Atmospheric and Ionospheric Disturbances Observed in GUVI With Multi‐Instrument Validations
Authors: Bossert Katrina , Paxton Larry J. , Matsuo Tomoko , Goncharenko Larisa , Kumari Komal , Conde Mark
Published: August 2022

This study presents multi‐instrument observations of persistent large‐scale traveling ionosphere/atmospheric disturbances (LSTIDs/LSTADs) observed during moderately increased auroral electrojet activity and a sudden stratospheric warming in the polar winter hemisphere. The Global Ultraviolet Imager (GUVI), Gravity field and steady‐state Ocean Circulation Explorer, Scanning Doppler Imaging Fabry–Perot Interferometers, and the Poker Flat Incoherent Scatter Radar are used to demonstrate the presence of LSTIDs/LSTADs between 19 UT and 5 UT on 18–19 January 2013 over the Alaska region down to lower midlatitudes. This study showcases the first use of GUVI for the study of LSTADs. These novel GUVI observations demonstrate the potential for the GUVI far ultraviolet emissions to be used for global‐scale studies of waves and atmospheric disturbances in the thermosphere, a region lacking in long‐term global measurements. These observations typify changes in the radiance from around 140 to 180 km, opening a new window into the behavior of the thermosphere.
Improving Surface Wind Speed Forecasts Using an Offline Surface Multilayer Model With Optimal Ground Forcing
Authors: Feng Jin , Huang Xiang‐Yu , Li Yanjie
Published: August 2022

An essential task of numerical weather prediction (NWP) is accurate surface wind speed prediction. However, current NWP models contain significant systematic errors due in part to indeterminate ground forcing (GF). This study considers an optimal virtual GF (GFo) derived by training observed and simulated data sets of 10‐m wind speeds (WS10) for summer and winter. The GFo is added to an offline surface multilayer model (SMM) to revise predictions of WS10 in China by the Weather Research and Forecasting model (WRF). This revision is a data‐based optimization under physical constraints. It reduces WS10 errors and offers wide applicability. The resulting model outperforms two purely physical forecasts (the original WRF forecast and the SMM with physical GF parameterized using urban, vegetation, and subgrid topography) and two purely data‐based revisions (i.e., multilinear regression and multilayer perceptron). Compared with the original WRF forecasting, using the GFo scheme reduces the root mean square error in WS10 across China by 25% in summer and 32% in winter. The frontal area index of GFo indicates that it includes both the effects of indeterminate GF and other possible complex physical processes associated with WS10.
Schelkunoff Formulation of the Sommerfeld Integral for the Hertzian Dipole Located in the Vicinity of Cylindrical Structures
Authors: Shaikh Tazeen , Ghosh Bratin , Bhattacharya Dhrubajyoti , Sarabandi Kamal
Published: August 2022

A numerical integration of the Sommerfeld integral is performed using the Schelkunoff formulation for cylindrical media. The Schelkunoff kernel for cylindrical media involves higher order modified Bessel functions with azimuthal summation over higher order modes. As such, the convergence characteristics of the cylindrical integral kernel are strongly dependent on complex linear combinations of higher order Bessel/Hankel/modified Bessel functions, compared to the case of the planar media where only a single Bessel/modified Bessel function of zeroth order is present. Two cylindrical configurations are analyzed using the new formulation, viz. a conducting cylinder and a dielectric‐coated conducting cylinder. The branch‐point singularity in the first configuration is removed using the angular transformation for the Sommerfeld/Schelkunoff formulations. A path deformation technique is used for the second configuration to address the problem of poles and branch‐point singularities on the real axis of integration. The in‐depth analysis of the cylindrical kernels and the integrals with variation in the location of the observation point clearly bring out the relative merits of both formulations for the cylindrical configurations, with the TE/TM coupling for the coated cylinder considered.
Treg-driven tumour control by PI3Kδ inhibition limits myeloid-derived suppressor cell expansion
Authors: Lauder Sarah N. , Smart Kathryn , Bart Valentina M. T. , Pires Ana , Scott Jake , Milutinovic Stefan , Godkin Andrew , Vanhaesebroeck Bart , Gallimore Awen
Published: August 2022

Background

Recent studies have demonstrated that blocking the PI3Kδ signalling enzyme (by administering a small molecule inhibitor, PI-3065) can potently improve the anti-tumour T-cell response through direct inhibition of Tregs. This treatment also has a negative impact on MDSC numbers but the primary mechanism driving this effect has remained unclear.

Methods

The 4T1 breast cancer mouse model was used in combination with PI-3065 to gain insights into the effect of PI3Kδ inhibition on MDSCs.

Results

PI-3065 treatment resulted in a concomitant reduction in MDSC expansion and tumour size. However, targeting Tregs independent of PI-3065 was also associated with reduced tumour volume and MDSC numbers. Surgical removal of tumours resulted in a rapid and significant decline in MDSC numbers, whilst ex vivo studies using cells from PI-3065-treated mice demonstrated no direct effect of the inhibitor on MDSC activity.

Conclusions

Our data suggest that MDSCs are not inhibited directly by PI-3065 treatment but that their reduced recruitment and immunosuppression within the tumour microenvironment is an indirect consequence of PI3Kδ-inhibition-driven tumour control. This indicates that PI3Kδ inhibition drives tumour immunity by breaking down multiple immunosuppressive pathways through both direct mechanisms (on Treg) and indirect mechanisms, secondary to tumour control (on MDSCs).
Transition metal impurities in silicon: computational search for a semiconductor qubit
Authors: Lee Cheng-Wei , Singh Meenakshi , Tamboli Adele C. , Stevanović Vladan
Published: August 2022

Semiconductors offer a promising platform for physical implementation of qubits, but their broad adoption is presently hindered by limited scalability and/or very low operating temperatures. Learning from the nitrogen-vacancy centers in diamond, our goal is to find equivalent optically active point defect centers in crystalline silicon, which could be advantageous for their scalability and integration with classical devices. Transition metal (TM) impurities in silicon are common paramagnetic deep defects, but a comprehensive theoretical study of the whole 3d series that considers generalized Koopmans’ condition is missing. We apply the HSE06(+U) method to examine their potential as optically active spin qubits and identify seven TM impurities that have optically allowed triplet–triplet transitions within the silicon band gap. These results provide the first step toward silicon-based qubits with higher operating temperatures for quantum sensing. Additionally, these point defects could lead to spin-photon interfaces in silicon-based qubits and devices for mid-infrared free-space communications.
Accurate large-scale simulations of siliceous zeolites by neural network potentials
Authors: Erlebach Andreas , Nachtigall Petr , Grajciar Lukáš
Published: August 2022

The computational discovery and design of zeolites is a crucial part of the chemical industry. Finding highly accurate while computational feasible protocol for identification of hypothetical siliceous frameworks that could be targeted experimentally is a great challenge. To tackle this challenge, we trained neural network potentials (NNP) with the SchNet architecture on a structurally diverse database of density functional theory (DFT) data. This database was iteratively extended by active learning to cover not only low-energy equilibrium configurations but also high-energy transition states. We demonstrate that the resulting reactive NNPs retain DFT accuracy for thermodynamic stabilities, vibrational properties, as well as reactive and non-reactive phase transformations. As a showcase, we screened an existing zeolite database and revealed >20k additional hypothetical frameworks in the thermodynamically accessible range of zeolite synthesis. Hence, our NNPs are expected to be essential for future high-throughput studies on the structure and reactivity of siliceous zeolites.
Detectability of simulated apical lesions on mandibular premolars and molars between radiographic intraoral and cone-beam computed tomography images: an ex vivo study
Authors: Wolf Thomas Gerhard , Castañeda-López Fernando , Gleißner Lisa , Schulze Ralf , Kuchen Robert , Briseño-Marroquín Benjamín
Published: August 2022

Adequate endodontic diagnostic is essential when making a therapy decision. Radiographic imagining acquisition methods (IAMs) are fundamental apical lesions of endodontic (ALE) origin diagnose tool. Thus, the aim of this research was to compare the simulated apical lesions (SALs) diagnose potential of digital intraoral radiography (DIR) and cone-beam computed tomography (CBCT), if there is a relationship between the IAMs, SALs-depth and their correct diagnose likelihood in human mandibular specimens’ datasets. 1024 SALs were prepared in cancellous and cortical bone with different penetration depths. The SALs-stages were radiographed with CBCT and DIR. The IAMs were randomly evaluated by 16 observers in two trials. Possible SAL findings were analyzed according to a five-point scale. The null hypothesis established that SALs detection accuracy does not differ between CBCT and DIR. Significantly differences (first 0.935 and second trial 0.960) were found for the CBCT area under the curve when compared with the DIR (first 0.859 and second trial 0.862) findings. SALs of smaller size were earlier detected by CBCT. In SALs without cortical involvement the probability of detection increased from 90 to 100%. The SALs-depth had the highest detectability influence on cancellous bone lesions and CBCT SALs detectability was 84.9% higher than with DIR images. The CBCT diagnose reproducibility was higher than the one of DIR (Kappa CBCT 75.7–81.4%; DIR 53.4–57.1%). Our results showed that CBCT has a higher SALs IAM diagnosing accuracy and that SALs detection accuracy incremented as the SALs-size increased.
Predictors of sedation period for critical illness patients focusing on early rehabilitation on the bed
Authors: Morimoto Yosuke , Watanabe Tsubasa , Oikawa Masato , Hanada Masatoshi , Sekino Motohiro , Hara Tetsuya , Kozu Ryo
Published: August 2022

There are various interventions of rehabilitation on the bed, but these are time-consuming and cannot be performed for all patients. The purpose of this study was to identify the patients who require early mobilization based on the level of sedation. We retrospectively evaluated the data of patients who underwent physical therapy, ICU admission of > 48 h, and were discharged alive. Sedation was defined as using sedative drugs and a Richmond Agitation–Sedation Scale score of < − 2. Multiple regression analysis was performed using sedation period as the objective variable, and receiver operating characteristic (ROC) curve and Spearman’s rank correlation coefficient were performed. Of 462 patients admitted to the ICU, the data of 138 patients were analyzed. The Sequential Organ Failure Assessment (SOFA) score and non-surgery and emergency surgery cases were extracted as significant factors. The ROC curve with a positive sedation period of more than 3 days revealed the SOFA cutoff score was 10. A significant positive correlation was found between sedation period and the initial day on early mobilization. High SOFA scores, non-surgery and emergency surgery cases may be indicators of early mobilization on the bed in the ICU.
The effects of personality traits and attitudes towards the rule on academic dishonesty among university students
Authors: Wang Hongyu , Zhang Yanyan
Published: August 2022

Academic dishonesty is becoming a big concern for the education systems worldwide. Despite much research on the factors associated with academic dishonesty and the methods to alleviate it, it remains a common problem at the university level. In the current study, we conducted a survey to link personality traits (using the HEXACO model) and people’s general attitudes towards the rule (i.e., “rule conditionality” and “perceived obligation to obey the law/rule”) to academic dishonesty among 370 university students. Using correlational analysis and structural equation modeling, the results indicated that both personality traits and attitudes towards the rule significantly predicted academic misconduct. The findings have important implications for researchers and university educators in dealing with academic misconduct.
Impact of lung function impairment after allogeneic hematopoietic stem cell transplantation
Authors: Kishida Yuya , Shingai Naoki , Hara Konan , Yomota Makiko , Kato Chika , Sakai Satoshi , Kambara Yasuhiro , Atsuta Yuya , Konuma Ryosuke , Wada Atsushi , Murakami Daisuke , Nakashima Shiori , Uchibori Yusuke , Onai Daishi , Hamamura Atsushi , Nishijima Akihiko , Toya Takashi , Shimizu Hiroaki , Najima Yuho , Kobayashi Takeshi , Sakamaki Hisashi , Ohashi Kazuteru , Doki Noriko
Published: August 2022

Late-onset noninfectious pulmonary complications (LONIPC) are a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). However, the clinical impact of lung function deterioration itself in long-term adult survivors of HSCT remains to be fully investigated. This retrospective, longitudinal study aimed to investigate pulmonary function following HSCT in terms of its change and the clinical significance of its decline. We examined 167 patients who survived for at least 2 years without relapse. The median follow-up period was 10.3 years. A linear mixed-effects model showed that the slope of pulmonary function tests values, including percent vital capacity (%VC), percent forced expiratory volume in one second (%FEV1), and FEV1/forced VC ratio (FEV1%), decreased over time. The cumulative incidence of newly obstructive and restrictive lung function impairment (LFI) at 10 years was 15.7% and 19.5%, respectively. Restrictive LFI was a significant, independent risk factor for overall survival (hazard ratio 7.11, P = 0.007) and non-relapse mortality (hazard ratio 12.19, P = 0.003). Our data demonstrated that lung function declined over time after HSCT and that the decline itself had a significant impact on survival regardless of LONIPC.
Numerical simulation of air age in dental offices
Authors: Nambu Eriko , Nozaki Kazunori , Tsubokura Makoto , Hayashi Mikako
Published: August 2022

Dental professionals are at high risk of exposure to communicable diseases during clinical practice, but many dental clinics provide clinical care in closed spaces. Therefore, it is essential to develop efficient ventilation methods in dental clinics that do not rely on natural ventilation. In this study, to clarify the factors that cause air retention in dental offices, we conducted computational flow dynamics simulations focusing on (1) the flow path from the entrance to the exhaust port and (2) the presence of partitions. A three-dimensional model of a dental clinic with three dental chairs was created, and simulations were conducted for scenarios with and without partitions with different entrance and exhaust port positions. Evaluation of these simulations on the basis of the age of air, an indicator of ventilation efficiency, showed that the value of the air age near the partition was locally high in the scenarios with partitions. In the scenarios where the exhaust port was located close to the entrance, the air age near the exhaust port was high, regardless of the presence of a partition. In addition to wearing protective clothing and sterilizing instruments, it is important to consider air quality improvement as a countermeasure against airborne and droplet infections, such as virus infections, in dental clinics.