bluuebunny/crossref_metadata_2025 huggingface dataset:
Theory and Applications of the (Cardio) Genomic Fabric Approach to Post-Ischemic and Hypoxia-Induced Heart Failure
Authors: Iacobas Dumitru Andrei , Xi Lei
Published: August 2022

The genomic fabric paradigm (GFP) characterizes the transcriptome topology by the transcripts’ abundances, the variability of the expression profile, and the inter-coordination of gene expressions in each pathophysiological condition. The expression variability analysis provides an indirect estimate of the cell capability to limit the stochastic fluctuations of the expression levels of key genes, while the expression coordination analysis determines the gene networks in functional pathways. This report illustrates the theoretical bases and the mathematical framework of the GFP with applications to our microarray data from mouse models of post ischemic, and constant and intermittent hypoxia-induced heart failures. GFP analyses revealed the myocardium priorities in keeping the expression of key genes within narrow intervals, determined the statistically significant gene interlinkages, and identified the gene master regulators in the mouse heart left ventricle under normal and ischemic conditions. We quantified the expression regulation, alteration of the expression control, and remodeling of the gene networks caused by the oxygen deprivation and determined the efficacy of the bone marrow mono-nuclear stem cell injections to restore the normal transcriptome. Through the comprehensive assessment of the transcriptome, GFP would pave the way towards the development of personalized gene therapy of cardiac diseases.
Adipokine Levels in Men with Coronary Atherosclerosis on the Background of Abdominal Obesity
Authors: Striukova Evgeniia Vital’evna , Shramko Victoriya Sergeevna , Kashtanova Elena Vladimirovna , Polonskaya Yana Vladimirovna , Stakhneva Ekaterina Mikhailovna , Kurguzov Alexey Vitalievich , Chernyavsky Alexander Mikhailovich , Ragino Yulia Igorevna
Published: August 2022

Background. Obesity is associated with dyslipidemia, and excess body fat is associated with unfavorable levels of adipokines and markers of inflammation. The goal of research. To study the level of adipokines and markers of inflammation, their associations with unstable atherosclerotic plaques in men with coronary atherosclerosis on the background of abdominal obesity. Materials and methods. The study involved 82 men aged 40–77 years with coronary atherosclerosis after endarterectomy from the coronary arteries. We divided all men into two groups: 37 men (45.1%) with unstable atherosclerotic plaques, and 45 men (54.9%) who had stable plaques. Obesity was established at a BMI of ≥30 kg/m2. The levels of adipokines and markers of inflammation in the blood were determined by multiplex analysis. Results. In patients with obesity and unstable plaques, the levels of C-peptide, TNFa and IL-6 were 1.8, 1.6, and 2.8 times higher, respectively, than in patients with obesity and stable plaques. The chance of having an unstable plaque increases with an increase in TNFa by 49% in obese patients and decreases with an increase in insulin by 3% in non-obese patients. Conclusions. In men with coronary atherosclerosis and obesity, unstable atherosclerotic plaques in the coronary arteries are directly associated with the level of TNF-α.
The Communication Chain of Genetic Risk: Analyses of Narrative Data Exploring Proband–Provider and Proband–Family Communication in Hereditary Breast and Ovarian Cancer
Authors: Pedrazzani Carla , Aceti Monica , Schweighoffer Reka , Kaiser-Grolimund Andrea , Bürki Nicole , Chappuis Pierre O. , Graffeo Rossella , Monnerat Christian , Pagani Olivia , Rabaglio Manuela , Katapodi Maria C. , Caiata-Zufferey Maria
Published: August 2022

Low uptake of genetic services among members of families with hereditary breast and ovarian cancer (HBOC) suggests limitations of proband-mediated communication of genetic risk. This study explored how genetic information proceeds from healthcare providers to probands and from probands to relatives, from the probands’ perspectives. Using a grounded-theory approach, we analyzed narrative data collected with individual interviews and focus groups from a sample of 48 women identified as carriers of HBOC-associated pathogenic variants from three linguistic regions of Switzerland. The findings describe the “communication chain”, confirming the difficulties of proband-mediated communication. Provider–proband communication is impacted by a three-level complexity in the way information about family communication is approached by providers, received by probands, and followed-up by the healthcare system. Probands’ decisions regarding disclosure of genetic risk are governed by dynamic and often contradictory logics of action, interconnected with individual and family characteristics, eventually compelling probands to engage in an arbitrating process. The findings highlight the relevance of probands’ involvement in the communication of genetic risk to relatives, suggesting the need to support them in navigating the complexity of family communication rather than replacing them in this process. Concrete actions at the clinical and health system levels are needed to improve proband-mediated communication.
Receiving Genomic Sequencing Results through the Victorian Undiagnosed Disease Program: Exploring Parental Experiences
Authors: Martinussen Jo , Chalk Michal , Elliott Justine , Gallacher Lyndon
Published: August 2022

Rare diseases cumulatively affect a significant number of people, and for many, a diagnosis remains elusive. The Victorian Undiagnosed Disease Program (UDP-Vic) utilizes deep phenotyping, advanced genomic sequencing and functional studies to diagnose children with rare diseases for which previous clinical testing has been non-diagnostic. Whereas the diagnostic outcomes of undiagnosed disease programs have been well-described, here, we explore how parents experience participation in the UDP-Vic and the impact of receiving both diagnostic and non-diagnostic genomic sequencing results for their children. Semi-structured interviews ranging in length from 25 to 105 min were conducted with 21 parents of children in the program. Ten participants were parents of children who received a diagnosis through the program, and eleven were parents of children who remain undiagnosed. Although the experiences of families varied, five shared themes emerged from the data: (1) searching for a diagnosis, (2) varied impact of receiving a result, (3) feelings of relief and disappointment, (4) seeking connection and (5) moving towards acceptance. The findings demonstrate the shared experience of parents of children with rare disease both before and after a genomic sequencing result. The results have implications for genetic counselors and clinicians offering genomic sequencing and supporting families of children with rare diseases.
Synergistic Effect of Motivation for the Elderly and Support for Going out
Authors: Mashimo Yumi , Tsuchihashi Saki , Tsutsui Kenta , Arai Tomoyuki , Tsuji Yoshitaka , Numai Toshiaki , Kameda Kazuo , Nishizawa Kyoko , Kovacs Mami , Tanaka Shukichi , Watanabe Hiroki , Naruse Yasushi , Ohmura Mitsuyo , Ishida Noriyuki , Iwasaki Toshiki , Hiruma Gaku , Miyazaki Naoki , Takemura Ryo , Nagashima Kengo , Sato Yasunori , Ohtsu Yui , Nakano Takashi , Aida Naomi , Iizuka Isao , Kato Hiromi , Kobayashi Yoshiki , Senbonmatsu Takaaki
Published: August 2022

Maintaining a social environment that enables going out freely is important for older people and aids the prevention of frailty syndrome. However, losing a driver’s license can increase the long-term care needs of older people. Therefore, outing support systems are important. However, the utilization rate of these systems is currently relatively low. We conducted a demonstration experiment among older people aged 70 years and over, living in Iruma City, Saitama Japan, by implementing the Choisoko outing support system developed by Aisin Co., Ltd., in conjunction with an approach for improving motivation. Using this system, elderly people were able to go shopping freely whenever they chose, without a driver’s license. Participants in the demonstration experiment exhibited higher Functional Independence Measure scores after the intervention, irrespective of whether or not they used the Choisoko system. The number of uses per person increased over time, and the subjective well-being of Choisoko users improved. However, few male participants engaged with the system. Although improving motivation is important for inducing positive behaviors and enabling the elderly to go out, motivation-improving factors differ between men and women.
Thinking about Enhanced Permeability and Retention Effect (EPR)
Authors: Leporatti Stefano
Published: August 2022

This invited editorial article aims at reporting progress about the enhanced permeability and retention effect (EPR for short), starting from a recent Special Issue in the Journal of Personalized Medicine (namely, “EPR Effect-Based Tumor Targeted Nanomedicine”) and focusing specifically on one of these contributing articles, a review from Jun Wu entitled “The Enhanced Permeability and Retention (EPR) Effect: The Significance of the Concept and Methods to Enhance Its Application”, which has recently acquired the rank of a highly cited paper [...]
Analysis of Mortality in Intracerebral Hemorrhage Patients with Hyperacute Ischemic Stroke Treated Using Thrombolytic Therapy: A Nationwide Population-based Cohort Study in South Korea
Authors: Choi Hyun-Young , Cho Yongil , Kim Wonhee , Minn Yang-Ki , Kang Gu-Hyun , Jang Yong-Soo , Lee Yoonje , Kim Jae-Guk , Kim Jihoon , Cho Youngsuk , Shin Hyungoo , Moon Shinje , Ahn Chiwon , Lee Juncheol , Shin Dong-Geum , Park Jae-Keun
Published: August 2022

This study investigated the impact of intracerebral hemorrhage (ICH) on the cumulative mortality of patients with hyperacute ischemic stroke. This population-based retrospective cohort study used claims data from the National Health Insurance Service customized database of South Korea. The recruitment period was 2005–2018. The study population included patients with hyperacute ischemic stroke who had received intravenous thrombolysis. The primary endpoint was 12-month cumulative mortality, which was analyzed in both the ICH and no-ICH groups. Of the 50,550 patients included, 2567 (5.1%) and 47,983 (94.9%) belonged to the ICH and no-ICH groups, respectively. In the univariable analysis for 12-month mortality, ICH patients were substantially more prevalent among dead patients than among patients who survived (11.6% versus 3.6%; p < 0.001). The overall 12-month cumulative mortality rate was 18.8%. Mortality in the ICH group was higher than that in the no-ICH group (42.8% versus 17.5%; p < 0.001). In the multivariable analysis, the risk of 12-month cumulative mortality was 2.97 times higher in the ICH group than in the no-ICH group (95% confidence interval, 2.79–3.16). The risk of 12-month cumulative mortality in hyperacute ischemic stroke can increase approximately threefold after the occurrence of spontaneous ICH following intravenous thrombolysis.
Association between Health Insurance Type and Genetic Testing and/or Counseling for Breast and Ovarian Cancer
Authors: Mansur Arian , Zhang Fang , Lu Christine Y.
Published: August 2022

As genetic testing becomes increasingly incorporated into clinical practice to aid in both the diagnosis and risk assessment of genetic diseases, patients benefit from genetic counseling to support their understanding of test results either before and/or after genetic testing. Therefore, access to genetic testing and counseling is imperative for patient care. It is well established that health insurance coverage is a major determinant of access to health care in the United States as individuals without insurance are less likely to have a regular source of health care than their insured counterparts. Different health insurance plans and benefits also influence patients’ access to health care. Data on the association of health insurance and the uptake of genetic testing and/or counseling for cancer risk are limited. Using data from the National Health Interview Survey, we examined the uptake of genetic testing and/or counseling for breast/ovarian cancer risk by health insurance type. We found that only a small proportion of women undergo genetic testing and/or counseling for breast/ovarian cancer risk (2.3%), even among subgroups of women at risk due to family or personal history (6.5%). Women with health insurance were more likely to undergo genetic testing and/or counseling for breast/ovarian cancer risk, particularly those with military and private insurance plans, than those without health insurance after adjusting for various demographic, socioeconomic, and health risk covariates. Further investigations are needed to examine potential disparities in access and health inequities.
A Comparison of Dynamic Contrast-Enhanced Magnetic Resonance Imaging and T2-Weighted Imaging in Determining the Depth of Myometrial Invasion in Endometrial Carcinoma—A Retrospective Study
Authors: Nurdillah Idris , Rizuana Iqbal Hussain , Suraya Aziz , Syazarina Sharis Osman
Published: August 2022

This study aims to compare dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with T2-weighted imaging (T2WI) in defining the depth of myometrial invasion in endometrial carcinoma. This retrospective study included 32 subjects with endometrial carcinoma who underwent 3.0T magnetic resonance imaging (MRI) prior to hysterectomy. DCE-MRI and T2WI were evaluated to determine the depth of myometrial invasion in endometrial carcinoma. A set of data consisting of the sensitivity, specificity, predictive values, and accuracy of DCE-MRI and T2WI were obtained and compared with the histopathological results. Out of the 32 cases included, the histopathological examination revealed that 50% myometrial invasion was found in 11 patients and ≥50% myometrial invasion was found in 21 patients. In the assessment of the tumor invasion, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of T2WI were 45.45%, 90.48 %, 71.43%, 76.0%, and 75.0%, respectively. The corresponding values for DCE-MRI were 81.82%, 76.19%, 64.29%, 88.89 %, and 78.12%, respectively. When T2WI were read together with DCE-MRI, the values were 90.91%, 90.48%, 83.33%, 95.0%, and 90.62%, respectively. Thus, the sensitivity and accuracy of DCE-MRI were greater compared to T2WI in defining the depth of myometrial invasion. However, the merging of T2WI and DCE-MRI increased the specificity and PPV value and improved the sensitivity, NPV and accuracy in detecting myometrial invasion. DCE-MRI was more sensitive but less specific than T2WI in defining the depth of myometrial invasion. In conclusion, combining DCE-MRI and T2WI further improves the diagnostic performance for myometrial invasion in endometrial carcinoma.
Disentangling Director Attributes: Human Capital versus Social Capital of Directors
Authors: Andersen Angela , Garel Alexandre , Gilbert Aaron , Tourani-Rad Alireza
Published: August 2022

This study seeks to disentangle the human capital and the social capital of directors to improve our understanding of the value that directors bring to their boardroom. Employing social network analysis (SNA) to measure the social capital of directors and using a unique and comprehensive sample of New Zealand publicly listed firms over the period of 2000–2015, we find a positive and significant relationship between the human capital and the social capital of directors, where the human capital appears to predict changes in social capital. We contend that the growing literature in the area of corporate finance and governance investigating the impact of characteristics of directors on corporate outcomes, need to take note of the complementary impact that social capital can have in addition to human capital.
A Generalized Entropy Approach to Portfolio Selection under a Hidden Markov Model
Authors: MacLean Leonard , Yu Lijun , Zhao Yonggan
Published: August 2022

This paper develops a dynamic portfolio selection model incorporating economic uncertainty for business cycles. It is assumed that the financial market at each point in time is defined by a hidden Markov model, which is characterized by the overall equity market returns and volatility. The risk associated with investment decisions is measured by the exponential Rényi entropy criterion, which summarizes the uncertainty in portfolio returns. Assuming asset returns are projected by a regime-switching regression model on the two market risk factors, we develop an entropy-based dynamic portfolio selection model constrained with the wealth surplus being greater than or equal to the shortfall over a target and the probability of shortfall being less than or equal to a specified level. In the empirical analysis, we use the select sector ETFs to test the asset pricing model and examine the portfolio performance. Weekly financial data from 31 December 1998 to 30 December 2018 is employed for the estimation of the hidden Markov model including the asset return parameters, while the out-of-sample period from 3 January 2019 to 30 April 2022 is used for portfolio performance testing. It is found that, under both the empirical Sharpe and return to entropy ratios, the dynamic portfolio under the proposed strategy is much improved in contrast with mean variance models.
The Use of Artificial Intelligence and Audit Quality: An Analysis from the Perspectives of External Auditors in the UAE
Authors: Noordin Nora Azima , Hussainey Khaled , Hayek Ahmad Faisal
Published: August 2022

This paper aims to explore external auditors’ perception of the use of artificial intelligence (AI) in the United Arab Emirates (UAE). It investigates whether there is a perception among external auditors toward the contribution of AI to audit quality. It also aims to test whether the perception of AI usage and its impact on audit quality differs between local and international external auditors. Data were collected using an online survey from 22 local and 41 international audit firms to achieve these research objectives. Participants were either the auditing manager, audit partners, senior auditors or other personnel who may have experience in the field of accounting and auditing. To test our hypotheses, data analysis was undertaken using reliability and validity tests, descriptive analysis and independent samples t-test. We found that the analysis shows that there is a non-significant difference in the perceived contribution of AI to audit quality between local and international audit firms. All the audit firms, whether local or international, have equal perceived contributions with regard to the audit quality.
Multi-Camera Extrinsic Calibration for Real-Time Tracking in Large Outdoor Environments
Authors: Tripicchio Paolo , D’Avella Salvatore , Camacho-Gonzalez Gerardo , Landolfi Lorenzo , Baris Gabriele , Avizzano Carlo Alberto , Filippeschi Alessandro
Published: August 2022

Calibrating intrinsic and extrinsic camera parameters is a fundamental problem that is a preliminary task for a wide variety of applications, from robotics to computer vision to surveillance and industrial tasks. With the advent of Internet of Things (IoT) technology and edge computing capabilities, the ability to track motion activities in large outdoor areas has become feasible. The proposed work presents a network of IoT camera nodes and a dissertation on two possible approaches for automatically estimating their poses. One approach follows the Structure from Motion (SfM) pipeline, while the other is marker-based. Both methods exploit the correspondence of features detected by cameras on synchronized frames. A preliminary indoor experiment was conducted to assess the performance of the two methods compared to ground truth measurements, employing a commercial tracking system of millimetric precision. Outdoor experiments directly compared the two approaches on a larger setup. The results show that the proposed SfM pipeline more accurately estimates the pose of the cameras. In addition, in the indoor setup, the same methods were used for a tracking application to show a practical use case.
Viewing the Landscape of the George Washington Memorial Parkway: A Cultural History of Scenic Resources and Landscape Ideology
Authors: Kelsch Paul J.
Published: August 2022

This paper investigates several views along the George Washington Memorial Parkway, which runs along the Potomac River between Washington, DC, and George Washington’s home, Mount Vernon. It focuses on the role these views have had in transforming the banks of the Potomac into a landscape, and it compares them to a set of landscape paintings that reveal complexities in the ideology of landscape. These dimensions of landscape ideology are used to interpret the parkway as a landscape, a projection of certain values on the land. The paper concludes with a discussion of the values of this approach for the stewardship of visual resources.
Visiting Peri-Urban Forestlands and Mountains during the COVID-19 Pandemic: Empirical Analysis on Effects of Land Use and Awareness of Visitors
Authors: Uchiyama Yuta , Kohsaka Ryo
Published: August 2022

This research analyzed the status of visiting peri-urban forestlands and mountains during the first COVID-19 emergency period in Japan using a large-scale online questionnaire-based survey. We identified and examined the factors that correlated with visits to such areas, including respondents’ social-economic attributes, environmental conditions (such as the land use patterns of their residential areas), and awareness of the functions of forestlands. The results suggest that environmental conditions are a major factor encouraging residents to visit peri-urban forestlands and mountains during the pandemic. Peri-urban areas with forestlands have such environmental conditions, and residents who visited peri-urban forestlands and mountains tended to live in peri-urban areas. Residents’ expectations regarding forest functions were also strong factors influencing them to visit those places. Those who visited forests and mountains expected these areas to have mental health and educational functions. Especially, female respondents tended to be aware of forestlands as spaces for mental and physical relaxation, and respondents who have one or more children tended to be aware of the educational functions of forests. These findings imply that policy should consider the role of environmental conditions, awareness, and expectations about the function of forests and mountains, and prior interactions with nature in encouraging residents to visit such places for their health during the pandemic. These factors could also play a role in addressing the social and environmental disparities that exist between residents of different socio-economic statuses regarding access to nature. In future research, the detailed relationships between residents’ environmental conditions and expectations/awareness of the functions of peri-urban forestlands and mountains need to be explored.
A Technical Tool for Urban Upgrading: An Application for Cultural Heritage Preservation and Planning for Affordable Housing
Authors: Potsiou Chryssy , Ioannidis Charalabos , Soile Sofia , Verykokou Styliani , Gkeli Maria , Filippakopoulou Maria
Published: August 2022

A technical tool to support projects for urban reforms and the implementation of current land policies is presented together with an example for its application in a project concerning the preservation of privately-owned residential buildings listed as “protected” cultural heritage (CH) constructions, urban planning and planning for affordable housing provision. The projects should be based on the voluntary participation of current property owners and an agreement signed between them and the private developer (team of professionals), so that the project will be self-financed through value capture measures to be decided by the state. The application presented here is based on the assumption that the state, by example, has set the rules for an increase in FAR in order to apply affordable housing policy and the preservation of listed CH residential private constructions. The state also provides the rules for identifying the target group of beneficiaries for affordable housing. Current property owners contribute the land, while the developer’s team undertakes all project costs. New property units are shared accordingly with the developer, the current owners and the beneficiaries for affordable housing. No additional public funds for the “affordable housing” units or for expropriation of the protected CH buildings is required.
Impact of Carbon Trading System on Green Economic Growth in China
Authors: Nie Xin , Chen Zhoupeng , Yang Linfang , Wang Qiaoling , He Jiaxin , Qin Huixian , Wang Han
Published: August 2022

Whether China’s economy can maintain sustainable growth has been debated both in China and internationally, and the most representative critique has been summarized in the “Krugman Query”. Faced with such doubts, how to achieve a “win-win” for economic growth and environmental protection has become one of the central objectives of local government work while striving for the new vision of development. Taking China’s carbon trading pilot policy as an example, and based on panel data of 30 provincial administrative regions in China from 2001 to 2018, this paper uses the Data Envelopment Analysis-Malmquist index model and the Propensity Score Matching-Difference in Difference method to measure the level of green economic growth from two aspects: green development mode and economic growth effect, and further explore the impact of China’s carbon trading system on green economic growth. The results show that the implementation of the carbon trading system promoted both the green development level and economic growth of pilot cities, and positively affected green total factor productivity, refuting the “Krugman Query”. Finally, the study puts forward a series of recommendations in strengthening environmental regulation, improving green technology innovation, and developing low-carbon industries.
How Can the Layout of Public Service Facilities Be Optimized to Reduce Travel-Related Carbon Emissions? Evidence from Changxing County, China
Authors: Yan Fengying , Huang Ningyu , Zhang Yehui
Published: August 2022

With the developments in urbanization and motorization, travel-related carbon emissions are increasing rapidly. The layout of public service facilities (LPSF) has a direct impact on travel-related carbon emissions. However, existing public service facility planning methods focus on population, economy, and other aspects, ignoring the environmental impact. So, how do we optimize the LPSF to reduce carbon emissions? This paper proposed a method to optimize the LPSF under the constraint of travel carbon emissions. We selected medical facilities in Changxing County, China, and applied the method we proposed. We found that (1) the carbon reduction effect was significant—the total monthly emissions in Changxing were reduced by 26.10%, and the area covered by high emissions was reduced; (2) the medical facilities in Changxing under a low-carbon goal should be distributed in the county center and surrounding urban areas in a multi-center form; and (3) improving the accessibility of facilities can help to form a low-carbon facilities layout. This paper provides a spatial planning method to guide the specific locations of facilities under low-carbon goals. It also provides scientific suggestions for low-carbon land-use policies at the county level in China.
Connections between Water, Energy and Landscape: The Social Acceptance in the Monachil River Valley (South of Spain)
Authors: Pérez Belén Pérez , Díaz-Cuevas Pilar
Published: August 2022

The relationship between water and renewable energy, as a vertebrate axis of the territory and landscape and its social acceptance in the Monachil river valley, was analysed. Qualitative interviews and surveys were designed and implemented using quantitative techniques that enabled the measure factors and dimensions of the perception of water, territory, and landscape. The main values and elements of the Monachil inventory, their links with ecosystem services, and traditional activities were identified. In addition, the influence of these premises on the acceptance of renewable energy projects was analysed. Results show that in Monachil, water is part of the territorial identity and landscape of the valley. There is also a strong link between the territory and hydroelectric power, which has generated a new energy landscape. More recently, solar energy has led them to pioneer an energy transition at the local scale. It is demonstrated how renewable energy infrastructures have been integrated into territorial practices.
Vegetation Drastically Reduces Wind Erosion: An Implementation of the RWEQ in the Mongolian Gobi Steppe
Authors: Talukdar Isita , Kowal Virginia , Huang Binbin , Weil Charlotte
Published: August 2022

Soil loss prevention is an important ecosystem service for protecting human and environmental health. Using spatiotemporal climate and environmental data of the Eastern Gobi Steppe, a region missing from previous studies of Mongolian wind-based soil erosion, we implemented the Revised Wind Erosion Equation (RWEQ) model to estimate soil loss. A replicable pipeline was developed to perform these computations, and made available openly. Soil loss was estimated on a monthly basis to analyze seasonal variations. The results show that the annual total soil loss was 61 × 1010 kg over an area of 69.3 × 103 km2, which is about 90 tonnes per hectare. Increasing fractional vegetation coverage to a uniform 50% coverage (doubling current vegetation coverage in every 1 km2) could reduce soil loss by 60%, highlighting the importance of protecting and increasing vegetation coverage in ecosystem service preservation.
Assessing Climate Change Adaptation and Risk Management Programmes: Stakeholder Participation Process and Policy Implications for Transport, Energy and Tourism Sectors on the Island of Sicily
Authors: Leon Carmelo J. , Lam González Yen E. , Ruggieri Giovanni , Calò Patrizia
Published: August 2022

Climate change is a critical sustainability challenge for islands and their main economic sectors. Rising sea levels, extreme temperatures, and drier conditions are the impacts with the most significant potential to amplify the economic damage on islands. However, their isolation and natural conditions bring about some leeway to respond to climate impacts on their terms. This paper aims to provide a local-level analysis and ranking of alternative adaptation pathways in an island context through the stakeholders’ lens. This study reviews the latest advancements in adaptation science and proposes a catalogue of adaptation and risk management options that feed a participatory assessment and ranking by local stakeholders. The research was conducted on the island of Sicily (Italy) and saw the participation of high-level experts and tourism, energy, and maritime transport representatives. It employs a sequential process of four ordered steps oriented towards adaptation planning and stakeholders’ engagement. The process reveals breaches between what stakeholders’ would prioritise when designing policy pathways and their opinion about the most beneficial and balanced adaptation programmes across the sustainability criteria. Results indicate that, according to stakeholders, the priorities are to prepare the energy, tourism, and maritime transport sectors to confront future climate-related events more efficiently. Other transformational actions to ensure long-term social-ecological resilience, which requires significant structural changes and substantial investments, are not at the core of the public needs.
Determining the Spatial Distribution Characteristics of Urban Regeneration Projects in China on the City Scale: The Case of Shenzhen
Authors: Liu Guiwen , Li Cheng , Zhuang Taozhi , Zheng Yuhan , Wu Hongjuan , Tang Jian
Published: August 2022

Urban regeneration (UR) has been a leading concern in urban studies globally. China’s rapid urbanization has undergone profound urban decay and social contestation, for which UR has emerged as a viable solution. However, UR is not without its drawbacks. It has caused emerging spatial and planning problems; however, few studies have explored the characteristics and issues of UR from the view of spatial analytics on the city scale. This study aims to depict the distribution characteristics of UR projects in Chinese cities and to reveal whether it meets the requirements of urban development from the planning perspective. The nearest neighbor index and its hierarchical clustering, as well as kernel density estimation are used in conjunction to investigate the spatial distribution characteristics; and the relationship between project distribution and each urban development indicator is explored using mixed spatial characteristics analyses, such as buffer analysis, space syntax, and heat mapping. Considering Shenzhen as the empirical study city, this research is based on all officially released data of implemented UR projects between 2010 and 2021. The findings imply that the UR projects in Shenzhen are mostly located in areas with higher economic development levels and accessibility with areas witnessing industrial restructuring and severe urban decay being prone to be designated for UR initiatives. The spatial distribution characteristics disclose the challenges inherent in the mix of top-down and market-driven UR approaches as well as the dilemma of the center-periphery pattern in UR implementation. Furthermore, the contradiction between the growing population and limited land resources as well as the barriers to industrial clustering formation are also revealed. This study enriches the methodological framework for spatial and visualization studies of urban regeneration in worldwide cities and sheds light on how to promote UR in regard to urban sustainability with ramifications for future urban development in other Chinese cities.
Soil Mycobiome Diversity under Different Tillage Practices in the South of West Siberia
Authors: Naumova Natalia , Barsukov Pavel , Baturina Olga , Rusalimova Olga , Kabilov Marsel
Published: August 2022

Managing soil biodiversity by reduced or no tillage is an increasingly popular approach. Soil mycobiome in Siberian agroecosystems has been scarcely studied; little is known about its changes due to tillage. We studied mycobiome in Chernozem under natural steppe vegetation and cropped for wheat by conventional or no tillage in a long-term field trial in West Siberia, Russia, by using ITS2 rDNA gene marker (Illumina MiSeq sequencing). Half of the identified OTUs were Ascomycota with 82% of the total number of sequence reads and showing, like other phyla (Basidiomycota, Zygomycota, Mortierellomycota, Chytridiomycota, Glomeromycota), field-related differential abundance. Several dominant genera (Mortierella, Chaetomium, Clonostachys, Gibberella, Fusarium, and Hypocrea) had increased abundance in both cropped soils as compared with the undisturbed one and therefore can be safely assumed to be associated with wheat residues. Fungal OTUs’ richness in cropped soils was less than in the undisturbed one; however, no tillage shifted soil mycobiome composition closer to the latter, albeit, it was still similar to the ploughed soil, despite different organic matter and wheat residue content. The study provided the first inventory of soil mycobiome under different tillage treatments in the south of West Siberia, where wheat production is an important section of the regional economy.
Comparison of the Use of Desflurane vs. Propofol in Aortic Valve Replacement Surgery: Differences in Nephroprotection: An Explorative and Hypothesis-Generating Study
Authors: Guerrero Orriach Jose Luis , Malo-Manso Alfredo , Nuñez Galo Mercedes , Bellido Estevez Inmaculada , Ruiz Salas Amalio , Cruz Mañas Jose , Garrido-Sanchez Lourdes , Gonzalez-Alvarez Laura
Published: August 2022

Introduction: The cardioprotective effect of halogenated drugs in cardiac surgery has been the subject of several studies. However, there is scarcity of data on their potential nephroprotective effects. Aortic valve replacement and coronary revascularization are the most frequent cardiac surgery procedures. The objective of this explorative study was to examine the effect of desflurane vs. propofol on renal function, when administered in aortic valve replacement surgery, including the extracorporeal circulation period. Method: A quasi-experimental prospective study was performed in 60 patients, who were allocated to receive either desflurane or propofol intraoperatively during aortic valve replacement surgery. As a hypnotic, group 1 received propofol, whereas group 2 received desflurane. Markers of renal function and level of cardiac preservation were determined based on biochemical parameters (troponin I, NTProBNP). Results: In the propofol group, there were significant variations between postoperative values of urinary NGAL and creatinine and baseline values. In contrast, no variations were found in the desflurane group in terms of hemodynamic parameters and myocardial damage. Conclusions: The use of propofol vs. desflurane during aortic valve replacement surgery is associated with a decrease in renal function.
3,6-Dichlorobenzene-1,2,4,5-tetraol
Authors: Aitken R. Alan , Schindler Niti , Slawin Alexandra M. Z.
Published: August 2022

The X-ray structure of the title compound as the monohydrate has been determined and shows a complex structure with two independent molecules each of the compound and water and eleven distinct hydrogen bonding interactions. Its melting point has also been recorded for the first time.
An Efficient Synthesis of Novel 4-Aryl-2-thioxo-3,4-dihydro-1H-pyrimido[1,2-a][1,3,5]triazin-6(2H)-ones and Their Antibacterial Activity
Authors: Van Quy Do , Van Hung Nguyen , Stolpovskaya Nadezhda , Kruzhilin Aleksey , Olshannikova Svetlana S. , Holyavka Marina , Sulimov Vladimir , Shikhaliev Khidmet
Published: August 2022

New substituted 4-aryl-8-methyl-2-thioxo-1,2,3,4-tetrahydro-6H-pyrimido[1,2-a][1,3,5]triazin-6-one 8a–b and ethyl 4-aryl-6-oxo-2-thioxo-1,3,4,6-tetrahydro-2H-pyrimido[1,2-a][1,3,5]triazine-7-carboxylate 8c–e were synthesized by the reaction of the corresponding 4-oxopyrimidin-2-ylthioureas with arylaldehydes. The formation of only one regioisomer was proven using complex spectral data and its structure was characterized. It was found that the interaction of 6-amino-4-phenyl-3,4-dihydro-1,3,5-triazine-2(1H)-thione with ethyl acetoacetate and diethyl ethoxymethylenemalonate leads to the formation of the same regioisomer. That is, changing the sequence of stages in this cascade process does not affect the structure of the final reaction product. All synthesized compounds exhibit antibacterial activity against E. coli and S. aureus cultures at a concentration (MIC) of 256 µg/mL.
Experimental Study on Carbonation of Cement-Based Materials in Underground Engineering
Authors: Zheng Jun , Zeng Gang , Zhou Hui , Cai Guanghua
Published: August 2022

The corrosive water environment has a decisive influence on the durability of a diversion tunnel lining. In this paper, the effects of carbonation on cement-based materials in water-immersion and saturated-humidity environments were studied by increasing the CO2 concentration. The results show that under conditions of water-immersion and saturated humidity, the color of the non-carbonation region is dark, while the carbonation region is gray, and the color boundary is obvious. However, in an atmospheric environment, there is no zone with a dark color and the color boundary is not obvious. In a saturated-humidity environment, the carbonation depth increases over time and changes greatly, and its value is about 16.71 mm at 200 days. While in a water-immersion environment, the carbonation depth varies little with time and the value is only 2.31 mm. The carbonation depths of cement mortar samples in different environments generally follow a linear relationship with the square root of time. The carbonation coefficient in a saturated-humidity environment is more than nine times that in the water-immersion environment. In a water-immersion environment, the carbonation causes a large loss of calcium in cement-based materials, and their Ca/Si ratio obviously decreases. The calcium silicon ratio (Ca/Si) of cement-based materials in a water-immersion environment is 0.11, which is much less than 1.51 in a water-saturated environment and 1.49 in an atmospheric environment. In a saturated-humidity environment, the carbonation only reduces the pH of the pore solution in the carbonation region, and the structural stability of cement-based materials is not degraded. The number of pores of all radii after carbonation in a water-immersion environment exceeds that in a saturated-humidity environment, and the total pore volume and average pore radius in a water-immersion environment are also larger than in a saturated-humidity environment, so the water-immersion environment accelerates the development and expansion of pores. The research results can provide some theoretical and technical support for the design, construction, and safe operation of diversion tunnel linings.
Individual Contribution of Zn and Ca on Age-Hardenability and Formability of Zn-Based Magnesium Alloy Sheet
Authors: Jo Sumi , Bohlen Jan , Kurz Gerrit
Published: August 2022

This paper reports on the dilemma of the strength and forming behavior of magnesium alloy sheets due to hot rolling and precipitation aging as an obstacle for property adjustment. The effect of the Zn content on the age-hardenability and formability of Mg-Zn-Al-Ca-Mn sheets was investigated. Sheets of two alloys with 2 or 4 wt.% Zn, respectively, were produced by casting and subsequent hot rolling and their microstructure development, precipitation behavior and formability were examined. With higher Zn content the age-hardenability was increased, but at the same time the formability of the sheet decreased, concurrent to the basal-type texture development during rolling. On the other hand, the sheet containing a lower amount of Zn exhibited a weak rolling texture and rather high formability but low age-hardenability. The addition of a larger amount of Zn improved the age-hardenability through the formation of β1′ and β2′ phases. The basal texture was exhibited due to the consumption of solute Ca due to the formation of the Ca2Mg6Zn3 phase. This study suggests that this contradictory exhibition of the age-hardenability and formability of Ca-containing and Zn-based alloy sheets requires a strategical approach in alloy and process design, which allows tailoring the alloying elements and processing for the respective purpose.
An Experimental Study of Auxetic Tubular Structures
Authors: Plewa Julian , Płońska Małgorzata , Feliksik Kamil
Published: August 2022

Auxetic tubular structures are widely known structures, characterized by a negative Poisson’s ratio upon stretching and deformation in the axial and transverse directions, which have numerous application possibilities. In this paper, tubular structures were realized by rolling up planar auxetic structures and using rigid square frames as unit cells. Planar and tubular structures were built from square frames that were 3D printed with plastic or laser-cut from metal. The changes in linear dimensions of the studied structures were based on a hinge mechanism, the functioning of which was experimentally verified on different solutions leading to square unit cells. To connect the square frames of the structure, an innovative solution was used in the form of rotation axes on their surface at a preset distance from the edge of the square frame. The geometric parameter thus introduced was used to determine the relative change in the size of the structure when stretched (i.e., when moving from the closed to the open position).
Microstructure Evolution and Deformation Mechanism of Tantalum–Tungsten Alloy Liner under Ultra-High Strain Rate by Explosive Detonation
Authors: Fu Heng , Jiang Jianwei , Men Jianbing , Gu Xinfu
Published: August 2022

The microstructure evolution and plastic deformation mechanism of a Ta-2.5W liner under the ultra-high-strain-rate conditions generated by the explosive detonation were investigated in this study. For this purpose, a modular soft-recovery apparatus was designed to non-destructively recover the Ta-2.5W explosively formed projectile (EFP) in the ballistic endpoint. The electron backscattered diffraction (EBSD) method was employed to examine the microstructure of the Ta-2.5W liner before and after deformation. The microstructure of the recovered EFP exhibited significant grain refinement with preferred fiber texture. The theoretical computation results showed that the temperature of the EFP was in the range of 0.27–0.65 Tm. The deformation mechanism of the Ta-2.5W liner forming EFP driven by the detonation is the continuous dynamic recrystallization (CDRX) induced by high strain deformation, rather than the conventional dynamic recrystallization of nucleation and growth. The new grain structures evolve when the low-angle grain boundaries are transformed into the high-angle grain boundaries, and the specific grain refinement mechanism is the progressive rotation of subgrains near pre-existing grain boundaries.
Oblique Low-Velocity Impact Response and Damage Behavior of Carbon-Epoxy Composite Laminates
Authors: Sun Jin , Huang Linhai , Zhao Junhua
Published: August 2022

The low-velocity impact behavior of carbon-epoxy cross-ply composites was numerically investigated, examining the effect of impact angle. A plastic continuum damage model, introducing the cohesive interface to describe delamination damage, was established and was validated by available experimental data. Impact histories, progressive deformation, stress transfer, and impact damage are respectively discussed. The results show that an increase in impact angle intensifies the action of tangential force, and gradually transfers energy absorption from normal plastic deformation to tangential deformation and friction, which dissipates more energy through relatively longer contact duration and larger impactor displacement. The delamination damage to upper layers is more affected by tangential loads, intensifying with the increase of the impact angle, and the damage area to the top interface is increased by 132.1% from 0° impact to 60° impact. Meanwhile, the delamination damage to lower layers is mainly determined by normal loads, weakening with the increasing impact angle overall, and the damage area of the lowest interface decreases by 36.6% from 0° impact to 60° impact.
Study on an Epoxy Resin System Used to Improve the Elasticity of Oil-Well Cement-Based Composites
Authors: Song Jianjian , Xu Mingbiao , Tan Chunqin , You Fuchang , Wang Xiaoliang , Zhou Shanshan
Published: August 2022

Oil-well cement-based materials have inherent brittleness; therefore, they cannot be directly used to seal oil and gas wells for a long time. To improve the elasticity of oil-well cement-based composites, a flexible epoxy resin system was developed. The flexibility, TG, and SEM of the cured resin system were evaluated. At the same time, the resin was added to oil-well cement-based materials to improve its elasticity. The compressive strength and elastic modulus of resin cement stone were tested, and the microstructure was analyzed by XRD, TG, and SEM/EDS. The results showed that the structure of the cured resin is compact, the thermal decomposition temperature is 243.9 °C, and it can recover its original shape after compression. At the curing age of 28 days, the compressive strength of cement-based composites containing 30% resin decreased by 26.7%, while the elastic modulus significantly decreased by 63.2%, and the elasticity of cement-based composites was significantly improved. The formation of hydration products (e.g., calcium silicate hydrate, and calcium hydroxide) in the resin cement slurry is obviously lower than that of pure cement, which is the reason for the decrease in compressive strength. The flexible structure of polymer particles and polymer film formed by epoxy resin is distributed inside the cement stone, which significantly improves the elasticity of oil-well cement-based composites. The results of this paper are helpful for the design of elastic cement slurry systems.