bluuebunny/crossref_metadata_2025 huggingface dataset:
Peranan Pentadbir Sekolah dalam Penghasilan Inovasi Pengajaran Guru
Authors: Wan Abdullah Wan Ali Akbar , Mohd Zhaffar Nursafra , Mahadi Mohd Hidayat , Usop Rossidi
Published: November 2024

Inovasi adalah kepakaran yang mesti dimiliki oleh pekerja di masa hadapan. Guru juga mesti memiliki kepakaran berinovasi agar kualiti pengajaran yang diberikan mencapai tahap piawaian yang ditetapkan. Namun, pelbagai kekangan perlu dihadapi oleh para guru menyebabkan mereka sukar untuk berinovasi. Walau bagaimanapun, terdapat segelintir guru yang dikesan konsisten menghasilkan inovasi. Fenomena ini menarik untuk diterokai. Kajian ini dijalankan untuk meneroka peranan yang dimainkan oleh pentadbir di peringkat sekolah dalam merangsang guru inovatif berinovasi. Kajian ini dijalankan dalam bentuk kajian kes. Seramai tujuh peserta kajian terlibat. Peserta kajian dipilih menggunakan teknik persampelan bertujuan dan dijejak menggunakan teknik bola salji. Data dikutip melalui temu bual secara separa berstruktur dan mendalam serta dianalisis dengan bantuan aplikasi NVivo. Kesahan dan keboleh percayaan data diperoleh melalui triangulasi, pengesahan peserta, berada lama di lapangan dan semakan protokol oleh pakar. Dapatan menunjukkan pentadbir di sekolah mengambil lima peranan untuk merangsang penghasilan inovasi di kalangan guru, iaitu; 1) sebagai pencetus budaya kerja inovatif, 2) komunikasi lisan, 3) memanfaatkan inovasi dalam program sekolah, 4) sama-sama berinovasi, dan 5) memanfaatkan kepakaran guru inovatif sedia ada. Dapatan kajian memberi panduan kepada para pentadbir untuk menyusun langkah agar berjaya mewujudkan budaya pengajaran inovatif di sekolah mereka.
دور مهارات التكنولوجيا في إدارة فصول تعلم الرياضيات عن بعد
Authors: Shkokani Riyad Abdelrazzaq , Suleiman Islaieh Abdelrahman Ibrahim , Mohammad Salleh Hamadallah , Shkokani Yasmeen Majed
Published: November 2024

This study aimed to identify the role of technological skills in managing distance Mathematics clases by Mathematics teachers of the higher primary level. To achieve the objectives of this study, we used a quantitative methodology and a questionnaire consisting of 12 items. The sample of the study consisted of 185 teachers from the Nablus Directorate of Palestine who were selected in a random stratified method. The results of the study showed that the degree of availability of technological skills was moderate. The results of the zero hypothesis tests in this study showed that there were no individual statistically significant differences in the degree of availability of technological skills because of the variables of academic qualification, scientific specialization, years of experience and statistically significant differences in the availability of technological skills attributable to gender and training. Based on these findings, the researchers recommend conducting further studies and research specializing in the distance learning system and in the skills needed for it. The researchers emphasized the importance of enhancing teachers' technological skills.
هدفت هذه الدراسة إلى التّعرف على دور المهارات التكنولوجية في إدارة فصول لتعلم الرياضيات عن بُعد لمعلمي المرحلة الأساسية العليا، ولتحقيق أهداف هذه الدراسة تم استخدام المنهج الكمي، وتم إعداد استبانة مكونة من (12) فقرة، وقد تكونت عينة الدراسة من (185) معلماً ومعلمة من مديرية نابلس في فلسطين، وتم اختيارهم بالطريقة الطبقية العشوائية، وأظهرت نتائج الدراسة أن درجة توافر المهارات التكنولوجية كانت بدرجة متوسطة، وأظهرت نتائج الاختبارات للفرضية الصفرية في هذه الدراسة، عدم وجود فروق فردية ذات دلالة إحصائية في درجة توافر المهارات التكنولوجية تُعزى إلى متغيرات المؤهل الأكاديمي، والتخصص العلمي، وسنوات الخبرة، كما أظهرت وجود فروق ذات دلالة إحصائية في درجة توافر المهارات التكنولوجية تُعزى إلى متغيري الجنس والتدريب، واستناداً إلى هذه النتائج، يوصي الباحثين بإجراء المزيد من الدراسات والبحوث المتخصصة في نظام التعلم عن بُعد، وفي المهارات اللازمة له، والاهتمام أكثر في تعزيز مهارات المعلمين التكنولوجية.
Trend Persekitaran Sosial dan Implikasi Terhadap Tanggungjawab Diri Remaja Generasi Z
Authors: Mohamad Amin Ahmad Fuad , Zakaria Zurkarnin , Spawi Mahiz , Sulieman Isleh Abdel Rahman , Anuar Nurul Atikah
Published: November 2024

Social problems among adolescents are closely related to the value of responsibility and the social environment that affects adolescents' self-concept. This review study was conducted to see the extent of the influence of the social environment in impacting the self-responsibility of Generation Z students. A total of 807 students in 22 SMKs around the state of Johor were randomly selected as the study sample. A questionnaire was administered as the data collection process. Data were analysed using SPSS software for descriptive and inferential analyses. Multiple Regression Analysis revealed that the social environment contributed up to 50% to the value of adolescent self-responsibility. This entails parents (β=0.304), curriculum activities (β=0.254), peers (β=0.221), teachers (β=0.139), and information technology media (β=0.077). This study demonstrates that the social environment plays a significant role in shaping adolescent self-concept that is responsible. The added value of the results of this study found that the extracurricular activities are the most important predictor that contributes to adolescent self-responsibility after parents, peers and teachers that need to be given attention by all parties.
ABSTRAK
Masalah sosial dalam kalangan remaja berkait rapat dengan nilai tanggungjawab dan persekitaran yang mempengaruhi konsep kendiri remaja. Kajian tinjauan ini dijalankan untuk melihat sejauh mana pengaruh persekitaran sosial dalam memberi impak kepada tanggungjawab diri pelajar Generasi Z. Seramai 807 orang pelajar di 22 buah SMK di sekitar negeri Johor dipilih secara rawak sebagai sampel kajian. Edaran soal selidik dijalankan sebagai proses pengumpulan data. Data dianalisis menggunakan perisian SPSS dengan menggunakan analisis deskriptif dan inferensi. Analisis Regresi Berganda menunjukkan persekitaran sosial menyumbang sebanyak 50% ke atas nilai tanggungjawab diri remaja. Ini merangkumi elemen ibu bapa (β=0.304), aktiviti kokurikulum (β=0.254), rakan sebaya (β=0.221), guru (β=0.139) dan media teknologi maklumat (β=0.077). Kajian ini memberi gambaran bahawa persekitaran sosial memainkan peranan penting untuk membentuk konsep diri remaja yang bertanggungjawab. Nilai tambah hasil kajian ini mendapati aktiviti kokurikulum menjadi peramal terpenting yang menyumbang kepada tanggungjawab diri remaja selepas ibu bapa, rakan sebaya dan guru yang perlu diberi perhatian oleh semua pihak.
Impact of regional characteristics on non-financial reporting taking into account the factor of war
Authors: Khodzytska Valentyna
Published: November 2024

According to statistical sources, about 80 % of the management of global investment funds claim that data on the sustainable development of economic entities affect their investment attractiveness. The provision of non-financial indicators in the annual reports of business entities is becoming more relevant both in the world and during the military aggression of Russia and the post-war reconstruction of the victorious Ukraine.
Therefore, the topic of determining the influence of regional characteristics for Ukrainian enterprises on non-financial reporting in the conditions of martial law acquires an actualizing strategic importance.
Comparison of Second-Trimester Uterine Artery Doppler Indices between Pregnant Women with and without Prior Cesarean Delivery and Effect on Perinatal Outcomes
Authors: Chaiprasit Bundaree , Mataneedol Suthasinee , Smanchat Buppa , Bhamarapravatana Kornkarn , Suwannarurk Komsun
Published: November 2024

Objective: To evaluate the effects of prior cesarean delivery on second-trimester Uterine Artery (UtA) Doppler and its effect on perinatal outcomes.
Materials and Methods: This study was conducted at the Maternal Fetal Medicine unit of Bhumibol Adulyadej Hospital, Thailand between June 2023 and January 2024. Healthy pregnant women aged between 18 and 45 years old were recruited and divided into prior (PCD) and non-prior cesarean delivery (non-PCD) groups. Both groups underwent UtA Doppler study from 18 to 24 weeks of gestation. UtA Doppler indices consisted of pulsatility index (UtA-PI), resistance index (UtA-RI) and systolic/diastolic ratio (S/D). Demographics, maternal and neonatal outcomes were collected.
Results: Total of 416 participants were recruited and divided equally. The mean age of participants was 30.5 years old. Diabetes mellitus in pregnancy and hypertensive disorder were reported as 18.9 (79/416) and 5.5 (23/416) percent, respectively. From univariate analysis, subjects in the PCD group had higher UtA-PI, UtA-RI and UtA S/D than the non-PCD group with statistical significance. After multiple logistic regressions, only UtA-RI was greater in the PCD group with any statistical significance. The mean gestational age at delivery was 38.41 weeks. Prevalence of small for gestational age deliveries, preeclampsia, and preterm birth were 4.4 (17/376), 3.1 (12/376) and 10 percent (38/376), respectively. Maternal and neonatal outcomes of both groups were comparable. Number of cesarean deliveries, parity, miscarriage, and anterior placentation were not associated with UtA Doppler indices.
Conclusion: UtA-RI of prior cesarean delivery participants were higher than non-prior cesarean delivery participants and not associated with maternal and neonatal adverse outcomes.
Health Survey of Monks Residing in Urban Areas: The Bangkok Noi Model
Authors: Ko-amornsup Wasumadee , Siriussawakul Arunotai , Aosangdeeku Kanuch , Preedachitkul Rinrada , Srinonprasert Varalak , Somnuke Pawit , Muangpaisan Weerasak , Petchthai Ponnapa , Kitnarong Naris
Published: November 2024

Objective: This study aimed to assess the prevalence of obesity and identify associated health problems and behaviors among monks residing in Bangkok Noi and its adjacent districts.
Materials and Methods: Employing a cross-sectional design, this research incorporated self-report questionnaires and specialized health checkup programs at a university hospital. Eligible participants were monks aged 20 years or older, living permanently in temples within the Bangkok Noi District and its adjacent districts. Monks in shortterm ordination were excluded. Data collection occurred between February 2022 and July 2023.
Results: Out of 560 monks who participated by completing both the questionnaires and health examinations, the average age was 46.49±16.97 years. Most participants resided in the Taling Chan (35.4%) and Bangkok Noi (31.8%) districts. Significant health issues included non-communicable diseases, with dyslipidemia affecting 57.8% and obesity 44.2% of the cohort. Monks over the age of 50 exhibited a remarkably higher rate of multimorbidity (50.2%) than their younger counterparts (24.2%, p < 0.001, 95% CI 20.71–27.97). Dietary habits revealed that younger monks were more prone to consuming fried, sweet and instant foods (74.5%, p < 0.001, 95% CI 70.67–78.07). Moreover, a significant proportion of younger monks demonstrated proficient e-health literacy (74.2%, p < 0.001, 95% CI 70.37–77.78).
Conclusion: The study highlights a high prevalence of obesity among monks in urban settings. There is a pressing need for tailored preventive interventions that integrate health promotion and lifestyle modifications through Dhamma and Vinaya teachings. The interventions should address the distinct needs of different age groups.
Outcomes of Microscopic Residual Tumor after Curative-Intent Surgery in Adenocarcinoma of Esophagogastric Junction
Authors: Nampoolsuksan Chawisa , Bhocksombud Khajohnsak , Parakonthun Thammawat , Suwatthanarak Tharathorn , Tawantanakorn Thikhamporn , Srisuworanan Nicha , Taweerutchana Voraboot , Trakarnsanga Atthaphorn , Phalanusitthepha Chainarong , Swangsri Jirawat , Akaraviputh Thawatchai , Methasate Asada , Chinswangwatanakul Vitoon
Published: November 2024

Objective: Radical surgery is the mainstay treatment for adenocarcinoma of the esophagogastric junction. The presence of microscopic residual tumor tissue after curative-intent surgery is associated with recurrence. This study compared the outcomes of patients with microscopic residual tumor (Residual+ group) and those without microscopic residual tumor (Residual- group).
Material and Methods: We retrospectively reviewed the medical records of 71 patients with adenocarcinomas of the esophagogastric junction who underwent curative-intent surgery between January 2005 and August 2018. We evaluated the clinical and pathological characteristics and compared recurrences, rates and patterns, between groups. Five-year overall survival (OS) and 3-year disease-free survival (DFS) were analyzed by Kaplan-Meier analysis.
Results: Nineteen (26.8%) patients had microscopic residual tumors, consisting of 8 (11.3%) with positive resection margins, 10 (14.0%) with malignant cells from peritoneal washing fluid cytology, and 1 (1.4%) with both. The median OS in the Residual- group was significantly better than that in the Residual+ group (31.3 vs 11.9 months, P = 0.003). The Residual- group had better 5-year OS (26.2% vs 11.9%, P = 0.015) and 3-year DFS (24.4% vs 9.8%, P = 0.003) than the Residual+ group. During follow-up period, 48% of the patients in the Residual+ group experienced recurrent disease, with a median follow-up time at 7.7 months. Distant metastasis was the most common site of recurrence.
Conclusion: Microscopic residual tumor after resection is associated with poorer survival outcomes and higher recurrence rates. Curative surgery should aim to achieve R0 resection in all patients with resectable adenocarcinomas of the esophagogastric junction.
Optimization of the Use of the DOTATATE Kit Manufactured by the Thailand Institute of Nuclear Technology Using a SiO2-based 68Ge/68Ga Generator
Authors: Jaiuea Phattarayut , Kongmuang Somlak , Lumyong Kanyapat , Doungta Thanete , Shiratori Shuichi
Published: November 2024

Objective: The presence of somatostatin receptors on neuroendocrine tumours enables 68Ga-DOTATATE to precisely detect lesion localization and staging. Thailand Institute of Nuclear Technology (TINT) recently developed a DOTATATE kit for labelling with Ga-68, which is compatible with a TiO2-based 68Ge/68Ga generator eluted with 0.1 M HCl, but presents a discrepancy with other types of 68Ge/68Ga generators. This research aimed to optimize a radiolabelling method using TINT’s kit with a SiO2-based 68Ge/68Ga generator eluting Ga-68 in 0.05 M HCl. Additionally, a quality control protocol was developed to ensure the formulation’s efficacy and reliability in compliance with the 10th edition of the European Pharmacopoeia.
Material and Methods: The SiO2-based 68Ge/68Ga generator was eluted with 2–4 ml of 0.05 M HCl, added into a lyophilized kit, heated in a dried-block heater at 100 ºC for 15 min, cooled down at room temperature, and finally purified using Sep-Pak C18 cartridge. The radiochemical purity was determined by radio thin-layer chromatography and the radioactivity was measured by a gamma well counter. Reproducibility and stability tests were conducted three times.
Results: Employing 4 ml of eluted material, comprising the second and fifth millilitres of 68GaCl3, provided a radiochemical purity (RCP) exceeding 95% after purification. Also, 68Ga-DOTATATE remained stable in refrigerator for at least 4 half-lives.
Conclusion: TINT’s DOTATATE kit can be successfully labelled with a SiO2-based 68Ge/68Ga generator, providing 68Ga-DOTATATE with an RCP > 95% for at least 4 half-lives when stored in refrigerator after production. This radiolabelling procedure is suitable for routine clinical application.
Особливості взаємозв’язку між агресивністю, копінг-поведінкою і конфліктністю у співробітників організації
Authors: Вдовіченко Оксана , Кондратьєва Ірина , Борозенцева Тетяна , Педченко Олександра
Published: November 2024

У статті представлено результати теоретичного аналізу та емпіричного дослідження проблеми взаємозв᾽язку агресивності, конфліктності та копінг-стратегій у працівників виробничої організації. Аналіз психологічної літератури з проблеми взаємозв'язку агресивності, подолання та конфліктної поведінки особистості показав, що ці поведінкові параметри тісно пов’язані між собою. Агресивна, конфліктна особистість зазвичай у стресовій ситуації обирає неконструктивні або захисні моделі долаючої поведінки. Це, як правило, пов’язано з особистісною незрілістю, відсутністю необхідних комунікативних навичок та умінь, а також – з вадами виховання.
Метою дослідженняє визначення особливостей взаємозв’язку агресивності, конфліктності та копінг-стратегій у працівників фармацевтичної компанії.
Наукова новизна. Проведене дослідження дозволило виявити що у досліджуваних підвищений рівень агресивності і конфліктності. Вони схильні до імпульсивного реагування в конфліктних ситуаціях, агресивного відстоювання власної точки зору, ухиляння від розв᾽язання проблеми в тих випадках, коли до конфлікту залучаються авторитетні особи.Також у досліджуваних переважають деструктивні копінг-стратегії. Це може негативно позначатися на якості ділового спілкування та продуктивності діяльності.
Висновки.Аналіз особливостей взаємозв'язку між агресивністю, копінг-поведінкою і конфліктністю у співробітників організації дозволяє констатувати, що конструктивні і неконструктивні стратегії долаючої поведінки взаємопов'язані з певними параметрами агресивності, конфліктності. В деяких випадках це сприяє успішному вирішенню проблем в стресових ситуаціях. Перспективами подальшого дослідження вбачаємо розробку та апробацію інтерактивної програми, що спрямована на формування продуктивного копінгу, оптимізацію конфліктності та агресивності у працівників організацій.
Ключові слова: агресивність, конфліктність, копінг-поведінка, співробітники організації.
Optimization of chitosan extraction from crustacean exoskeleton wastes
Authors:   Faculty of Chemical Engineering and Biotechnology, National University of Science and Technology POLITEHNICA Bucharest, 1 Ghe. Polizu Str., Bucharest, Roumania, GÎJIU Cristiana Luminița , APETROAEI Manuela Rossemary ,   Department of Marine Electric and Electronic Engineering, Faculty of Marine Engineering, Mircea cel Batran Naval Academy, 1 Fulgerului Street, 900218 Constanta, Roumania, APETROAEI Miruna-Maria ,   Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Roumania, ISOPESCU Raluca ,   Faculty of Chemical Engineering and Biotechnology, National University of Science and Technology POLITEHNICA Bucharest, 1 Ghe. Polizu Str., Bucharest, Roumania, ANTON Mirela ,   12:00:00 AM, RĂU Ileana ,   Faculty of Chemical Engineering and Biotechnology, National University of Science and Technology POLITEHNICA Bucharest, 1 Ghe. Polizu Str., Bucharest, Roumania, SCHRÖDER Verginica ,   Faculty of Pharmacy, Ovidius University Constanta, Constanta 900470, Roumania
Published: November 2024

The degree of deacetylation, DDA is the most important characteristic for a specific chitosan sample as it mainly influences its chemical and biological properties. Several natural wastes may be used as sources for chitin as for example crabs’ and shrimps’ exoskeletons, and the yield of chitosan extraction is generally small and depends on the chitin extraction and the deacetylation step. The simultaneous maximization of yield and deacetylation degree DDA pointed out some optimal operating conditions of the deacetylation procedure. The maximum yield and maximum DDA can be obtained working with higher NaOH concentrations and longer duration of this step.
Comparison between Gaussian and advection diffusion equation of Eulerian and Lagrangian integral time scales in stable condition
Authors:   Department of Mathematics and Theoretical Physics, Nuclear Research Centre, Egyptian Atomic Energy Authority, Cairo, Egypt., ESSA Khaled S. M. , TAHA Hanna M. ,   Department of Mathematics and Theoretical Physics, Nuclear Research Centre, Egyptian Atomic Energy Authority, Cairo, Egypt.
Published: November 2024

The displacement mean-square parameters (X^2 ) ̅(t),(Y^2 ) ̅(t)and (Z^2 ) ̅(t)need to be increasing functions of time. In a stable and homogeneous field of turbulence, the variances of Lagrangian velocity fluctuations must be equal to the corresponding Eulerian velocity variances and independent of time. The mean-square particle displacement rises proportionately to the square of the diffusion time "t2" for small diffusion times. The mean-square diffusion finally becomes proportional to the diffusion time (t) and the Lagrangian integral time scale (TiL) for long diffusion times. The three-dimensional advection-diffusion equation and Gaussian model are computed using these dispersion values. The results of these concentrations are contrasted with Iodine-131 experimental data that was gathered at the Egyptian Atomic Energy Authority under steady conditions.
Von Willebrand Disease and Angiodysplasia: a wider view of pathogenesis in pursuit of therapy
Authors: Crossette-Thambiah Christina , Randi Anna M. , Laffan Michael
Published: November 2024

Bleeding in the GI tract continues to pose a therapeutic challenge for clinicians in patients with Von Willebrand Disease (VWD). It is associated with significant morbidity and mortality and represents the major unmet need in VWD. Defective angiogenesis in the gut is primarily responsible, resulting in angiodysplastic malformations making bleeding notoriously refractory to standard replacement therapy. A substantial body of evidence now shows that Von Willebrand Factor (VWF) has a role in the regulation of angiogenesis but the mechanisms responsible for the formation of vascular malformations remain incompletely understood. Data from the wider field of vascular malformations may lend insight and point to novel therapeutic approaches. Here we review evidence linking VWF to angiodysplasia, the associated molecular mechanisms and the implications for therapy.
Cumulative review of hypertension in patients with chronic lymphocytic leukemia treated with acalabrutinib
Authors: Ferrajoli Alessandra , Follows George , Marmor Yotvat , Roos Jack , Bajwa Naghmana , Madhira Venkata , Nozaki Kenji , Miranda Paulo , Pennap Dinci , Patel Krish
Published: November 2024

Not available.
Venetoclax in combination with a pediatric-inspired regimen for the treatment of newly diagnosed adults with Philadelphia chromosome-negative acute lymphoblastic leukemia
Authors: Aldoss Ibrahim , Zhang Jianying , Shimamoto Kathryn , Saygin Caner , Robbins Marjorie , Agrawal Vaibhav , Aribi Ahmed , Karaoglu Diren Arda , Pourhassan Hoda , Koller Paul , Ali Haris , Blackmon Amanda , Otoukesh Salman , Sandhu Karamjeet , Ball Brian , Artz Andrew S. , Al Malki Monzr M. , Salhotra Amandeep , Tinajero Jose , Gu Zhaohui , Lagman Ian , Velasquez Michelle , Dang Jacqueline , Becker Pamela S. , Afkhami Michelle , Ghoda Lucy , Stock Wendy , Forman Stephen J , Stein Anthony , Marcucci Guido , Pullarkat Vinod
Published: November 2024

BCL-2 protein overexpression, common in B-cell acute lymphoblastic leukemia (B-ALL), including the Philadelphia (Ph)-like subtype, mediates leukemic cell survival. We treated 24 patients with 14 days of BCL-2 inhibitor, venetoclax, 400 mg daily (dose level 1) during induction and consolidation cycles combined with the CALGB 10403 regimen in newly diagnosed adults with Ph-negative B-ALL. Median age was 31 (range: 18-53) years, 92% were Hispanic, and 12 (50%) patients had Ph-like ALL. No dose limiting toxicity occurred in the phase 1 part. Median times to neutrophil and platelet count recovery were 20 and 21 days from start of induction, respectively. The most common grade ≥3 treatment-related adverse events were leukopenia (96%), neutropenia (83%), anemia (83%), thrombocytopenia (79%), lymphopenia (71%), hyperbilirubinemia (38%), and elevated ALT (33%). One patient with non-Ph-like ALL died from asparaginase-associated pancreatitis, and 23 (96%) patients achieved complete remission (CR) or CR with incomplete count recovery (CRi) following induction with or without extended induction phase. Of 22 patients who started consolidation, 20 (91%) achieved negative minimal residual disease status (MRD-) (
Pathogenic Variants in the ABCA12 Gene Associated to Autosomal Recessive Congenital Ichthyosis: Report of an Attenuated Phenotype
Authors: Beltrán Gabriela Mantilla , Pinilla Ana María Navarro , Mantilla Diego Andrés Padilla , Camacho Alfonso Suárez , Candia Mónica Paola Novoa
Published: November 2024

Congenital ichthyosis represents keratinisation disorders characterised by abnormal skin scaling across the entire body, leading to a red, denuded, and scaly appearance. A subgroup of this is the autosomal recessive congenital ichthyosis (ARCI), characterised by a severe phenotype and classified according to the molecular mechanisms that underlie the disease. This article reports on the cases of two female patients with symptoms of palmoplantar keratoderma since birth and a variant in the ABCA12 gene that encodes an amino acid glucosylceramide transporter known as ABCA12. The primary role of ABCA12 is to facilitate the transport of molecules across cell and intracellular membranes. Variants involve large deletions and nonsense variants, resulting in a truncated protein that contributes to the severity of harlequin ichthyosis. However, the patients reported in this article present an attenuated phenotype with palmoplantar keratoderma. The subdued presentation in these patients might be elucidated by their compound heterozygous status.
Mechanistic Understanding of Clinical Response to Bimekizumab in Psoriatic Disease
Authors: Roberts Eleanor
Published: November 2024

Use of bimekizumab, a monoclonal immunoglobulin G1 (IgG1) antibody that selectively inhibits the cytokine interleukin-17F (IL-17F), in addition to IL-17A, has been shown to result in a rapid response and prolonged, high-level disease control in patients with moderate-to-severe plaque psoriasis. At the 2024 European Academy of Dermatology and Venereology (EADV) Congress, an oral presentation and a poster were presented related to furthering the understanding of the mechanisms that lead to the clinical response observed with bimekizumab. The oral presentation examined the effects of bimekizumab on subcomponents of the Psoriasis Area and Severity Index (PASI). Analyses showed ≥95% mean improvement in erythema, thickness, and scaling with bimekizumab by Week 12 of treatment, which was maintained to Week 48. Bulk transcriptomic analysis showed complete normalisation of gene signatures associated with these subcomponents by Week 8, preceding clinically apparent skin clearance. A poster presented at the 2023 5th Inflammatory Skin Diseases (ISDS) focused on the effect of bimekizumab on tissue-resident memory T (TRM­) cells, which have been associated with disease perpetuation during treatment and with psoriasis recurrence at the same location following treatment withdrawal. Bulk transcriptomic analyses showed normalisation of a TRM gene signature at Week 8 after only two doses of bimekizumab, as well as normalised expression of pro-survival factors that may be prolonging survival of pathogenic TRM cells and pathogenic IL-17A/F-secreting cells. These results may have implications for disease modification and help explain the long-term durability of response observed with bimekizumab. The results shown in the oral presentation and poster support the rationale for initiation of the BE UNIQUE study, the protocol for which was reported at EADV 2024. This ongoing, multicentre, Phase IIIb study is recruiting patients with moderate-to-severe plaque psoriasis, with or without concomitant active psoriatic arthritis, with a primary objective to assess change in composite gene expression score at Week 48. This study aims to further elucidate the molecular mechanisms underlying the rapid, high-level, and durable clinical responses observed with bimekizumab.
Current Landscape and Emerging Therapies in Hair Loss Treatment for Androgenetic Alopecia
Authors: Boreham Helen
Published: November 2024

Androgen hormones and signalling via the androgen receptor play a key role in regulating the hair cycle and are strongly implicated in the pathogenesis of androgenetic alopecia (AGA). CosmeRNA ARI (ARI, androgen receptor inhibitor) (Bioneer Corp, Seoul, South Korea), which utilises Self-Assembled Micelle Inhibitory RNA (SAMiRNATM) technology represents a distinct approach to treating AGA that is applied topically and selectively targets androgen receptor (AR) mRNA to downregulate overexpression of the androgen receptor. In clinical studies, inhibiting androgen receptor expression using SAMiRNA micelles was shown to be an effective approach to treating AGA that significantly increased hair growth. During interviews conducted by the European Medical Journal (EMJ), two leading experts in the field of hair loss, Sergio Vañó-Galván, Director of the Hair Disorders Unit at Ramón y Cajal University Hospital and Associate Professor of Dermatology at the University of Alcalá in Madrid, Spain, and Young-jin Park from the Yas Clinic, Khalifa City in the UAE, discussed the current and future therapeutic landscape in AGA, and considered the role of SAMiRNA as a promising new treatment approach.
Vitiligo, Beyond White Patches
Authors: Moir Hannah
Published: November 2024

This article reviews an industry-sponsored satellite symposium that took place at the European Academy of Dermatology and Venereology (EADV) Congress 2024 held in Amsterdam, the Netherlands, on 27th September 2024.

The session, chaired by Khaled Ezzedine, Professor of Dermatology at Hôpital Henri-Mondor, France, addressed understanding the disease burden of vitiligo and the challenges of accessing optimal care. The session established vitiligo as an autoimmune disease requiring both early and long-term management, as well as utilising shared decision-making in treatment options.

Albert Wolkerstorfer, Professor of Dermatology at Amsterdam University Medical Centres, the Netherlands, discussed the underestimated burden of vitiligo disease, including psychological comorbidities, and the impact on quality of life (QoL) compared to other chronic diseases such as psoriasis. He also identified the challenges such as delayed diagnosis and lack of knowledge, and how this impacts access to optimal care.

Curtin Conrad, Professor of Dermatology and Head of the Polyclinic and Centre for Psoriasis Lausanne University Hospital, Switzerland, then considered the pathogenesis of non-segmental vitiligo, focusing on the role of the JAK-signal STAT pathway and how it drives the disease mechanisms and maintenance, emphasising the important need for early intervention and long-term considerations for the management of vitiligo.

Finally, Markus Böhm, Professor of Dermatology at the University Hospital Münster, Germany, identified the importance of utilising shared decision-making in vitiligo treatment strategies, especially for long-term commitment, and how ruxolitinib cream fits into this shared decision-making and overall treatment strategy, considering the efficacy and safety data.
Skin Microbiome and Acne: Microbial Imbalances and Impact – Interview with Three Key Opinion Leaders
Authors: Scott Brigitte
Published: November 2024

Acne vulgaris, commonly known as acne, is a multifactorial, chronic inflammatory skin condition involving the pilosebaceous unit, and is one of the most common skin diseases globally. Acne significantly impacts the quality of life and wellbeing of patients, and can be associated with anxiety, depression, and low self-esteem. This skin condition is also associated with substantial healthcare costs and economic burden for society. The treatment of acne is complex and challenging. For this article, EMJ conducted an interview in September 2024 with key opinion leaders Marco Rocha from Federal University of São Paulo, and Brazilian Society of Dermatology, Brazil; Thomas Dirschka from CentroDerm Clinic, Wuppertal, and University of Witten-Herdecke, Germany; and Alison Layton from the Skin Research Centre, Hull York Medical School, University of York, and Harrogate and District NHS Foundation Trust, UK. The key opinion leaders, who have a wealth of experience and expertise in the clinical management of acne, were asked about the current landscape for the management of acne, and the potential role of the skin microbiome in the development and treatment of this chronic inflammatory skin disease. The experts provided valuable insights into some of the many unmet needs in acne management, particularly the overuse of antibiotics and the lack of effective alternative therapies for this condition. The experts discussed the contribution of the skin microbiome and the potential role of microbial imbalances in the development of acne, and the potential of prebiotics and probiotics in restoring skin health. The concept of integrating microbiome-modulating strategies into conventional acne treatment, and whether there is a connection between the skin microbiome and psychological conditions such as depression, were also considered. A further topic covered was educating patients and parents about acne. Finally, the experts outlined what the future landscape of acne management might look like.
Gradation of the severity of myofascial pain syndrome of the masticatory muscles
Authors: Yarygina E. N. , Shkarin V. V. , Makedonova Yu. A. , Kurezov A. K. , Devyatchenko L. A. , Afanasyeva O Yu.
Published: November 2024

Relevance. Due to the high prevalence of myofascial pain syndrome of the masticatory muscles, the issue of treatment of this pathology remains relevant. Due to the heterogeneity of the severity of clinical manifestations, these additional examination methods, the development of a treatment plan by a dentist causes certain difficulties.

Materials and methods. Based on the data of a clinical and functional examination of 102 people aged 18 to 35 years, a gradation of the severity of MBS of the masticatory muscles was developed. In a clinical study, the presence and severity of pain during palpation, the degree of mouth opening, and an assessment of functional activity on the MAS scale were determined. Ultrasound examination was used to study the indicators of the area and thickness of the cross-section of the chewing muscles, visualization and size of trigger points. According to the electromyographic study, a comparative analysis of the average amplitude of the masticatory muscle, the total biopotential, and an assessment of the symmetry of the masticatory muscles was carried out.

Results. The data obtained made it possible to develop a gradation of the severity of MBS by 3 degrees, depending on the indicators (mild, moderate, high).

Conclusion. The development of this graduation will allow for an individual patient-oriented approach to the treatment of this category of people, which will contribute to improving the quality of medical care at a dental appointment
Clinical experience of the carboxytherapy method in the treatment of patients with temporomandibular joint pain dysfunction syndrome (К07.60)
Authors: Shipika D. V. , Popova K. A. , Ostashko A. A. , Bagoviev A. D. , Darkhanova A. E. , Drobyshev A. Y.
Published: November 2024

Objective. Improving the effectiveness of treatment of patients with TMJ PDS myogenic origin.

Material and methods. According to the purpose of the study, a group of 10 patients (8 women and 2 men aged 14 to 60 years) was formed with the coincidence of a triad of signs: pain during movements of the lower jaw, a feeling of heaviness and tension in the chewing and facial muscles, restriction of mouth opening. A set of diagnostic measures has been implemented in the following scope: clinical and radiological examination methods, TMJ MRI, ultrasound and surface EMG of the chewing muscles, digital axiography. In the treatment of patients in the study group, the method of invasive carboxytherapy was used, based on dosed injections of CO2 in the projection of trigger points of the masticatory muscles. The research examines the therapeutic value of using of CO2 in the protocol of functional rehabilitation of patients with TMJ diseases of myogenic origin.

Results. The analysis of the effectiveness of treatment of patients in the study group was carried out to assess the dynamics of key parameters: the severity of the pain syndrome according to VAS, the magnitude of the IMPACT index values and the magnitude of mouth opening. The severity of pain in patients in the study group, according to average values, decreased by 86% from the initial values, an increase in the amplitude of mouth opening by 28.5%, a decrease in the IMPACT index values by 42.5% from the initial values of hypertonicity of the masticatory muscles, an increase in blood flow speed of superficial temporal artery at 52.5%.

Conclusion. The results of the clinical application of the carboxytherapy method in the treatment of patients with TMJ PDS allow us to recommend this method for implementation in the rehabilitation protocols of patients with TMJ PDS of myogenic origin, trismus and hypertonus of the masticatory muscles. Carboxytherapy as a method of etiopathogenetic rehabilitation contributes to the early relief of pain syndrome, normalization of the bioelectric activity of the chewing muscles and restoration the physiological kinematics of the lower jaw’s movements.
Prosthetic stomatitis: treatment and prevention
Authors: Kerimkhanov K. A. , Bedelov N. N. , Iordanishvili A. K.
Published: November 2024

Relevance. Traumatic prosthodontic stomatitis is the most frequent in clinical prosthetic dentistry, increasing the effectiveness of prevention and treatment of which is considered an urgent problem of practical dentistry.

Objective. To study the effectiveness of using various domestic means for oral care in patients suffering from traumatic prosthetic stomatitis

. Materials and methods. The study involved 42 elderly patients suffering from denture stomatitis due to the use of removable acrylic dentures. The patients were divided into 2 groups. In the control group after dentures correction they were recommended to use rinses and irrigations of the oral cavity with antiseptic solutions for a week, and later with infusions of medicinal herbs. Patients of the main group during their follow-up used local anti-inflammatory and wound-healing agents produced by thedomestic industry, as well as those improving the fixation of removable dentures. The effectiveness of denture stomatitis treatment and prevention of recurrence was evaluated on the basis of the patient’s complaints and clinical condition of the oral mucosa.

 Results. . It was established that for effective therapy of denture stomatitis it is necessary to use specially produced anti-inflammatory agents for the oral cavity during the period of acute inflammatory changes in the mucous membrane of the denture bed, and when using removable acrylic dentures it is necessary to recommend ASEPTA denture fixation cream, which has proved itself not only in the aspect of optimization of microbiota and mucosal immunity of the mouth, but also for optimization of psychophysiological state of patients. Their use makes it possible to achieve 81.47% efficacy of prosthetic stomatitis treatment on the 5th day and 100% efficacy of therapy on the 7th day from the beginning of their use by the patient, as well as in the nearest period to provide prevention of this disease recurrence.

Conclusion. For secondary prophylaxis of traumatic prosthetic stomatitis, which occurs most often among the complications when patients use removable acrylic dentures, it is advisable to use specially produced by the domestic industry means possessing anti-inflammatory and wound-healing properties, as well as favorably acting on the mucous membrane of the prosthetic bed.
Biochemical parameters and oral fluid microcrystallization in young patients who use a vape device
Authors: Zolotova L. Yu , Berezneva E. Yu. , Solonenko A. P. , Lomiashvili L. M. , Gaberkorn A. A. , Zolotova S. A.
Published: November 2024

The study aims s are researching the negative effect of nicotine-containing vapes on physical and chemical parameters of oral fluid and morphotyping of dried oral fluid drop among young somatically healthy individuals.

 Material and methods. The study included 20 people between the ages of 18 and 24 years old, divided into 2 groups: the «Vape» group (n=12) human only nicotine-containing vape for at least 2 years and the «Control» group (n=8) not human nicotine in any form. pH, thiocyanate (rhodonide) concentrations, surface tension, oral fluid volume, hygiene indices and periodontal indices were studied. The morphotype of dried oral fluid drop was analyzed.

Results. In the «Control» group in 3 cases gingivitis chronic K05.1 was diagnosed, and in the patients of the «Vape» group in 9 cases. It was found that the rhodonide content in the «Vape» group before «vaping» was higher than in the «Control» group and was Me= 1.31 mM/L and Me=0.58 mM/L respectively p=0.012. After vape application, the concentration of rhodonides in oral fluid increased in 1.16 times (p=0.0077), nitrite ions content from Me=0.09 mg/L to Me=0.32 mg/L (p=0.07), pH increased to Me=7.64; (LQ=7.45; HQ=7.67) (p=0.07) (p=0.07). The volume of RW in the Vape group remains 2.8 times smaller than in the Control group (p=0.012). The microcrystallization pattern of the oral fluid drop in the «Vape» group before «steaming» more often corresponded to type II A, and after «steaming» in 33.4% cases type III was determined, in 25% – type II B.

Conclusions. Thus, in «vapers» of 18–24 years old statistically reliable reduction of oral fluid volume, high values of hygiene index shift of acid-base balance in the direction of alkalosis creates conditions in the oral cavity for the development of periodontal diseases and the emergence of cariesogenic situation. There was an increase in the concentration of rhodanide and nitrite ions, which in combination with other components of vape aerosols can be considered as procarcinogens, syncarcinogens and cocarcinogens. The change in the morphology of facies pattern, type of microcrystallization of oral fluid drop in the dynamics of vape use corresponds to the vector of changes observed in other inflammatory diseases of the oral cavity
Assessment of clinical and laboratory parameters of oral сavity in patients with orthodontic systems
Authors: Kontorshchikova K. N. , Kazarina I. N. , Gushchina O. O. , Lyadova A. A. , Stepankova S. G. , Kazarin A. S.
Published: November 2024

equipment (braces) on the biochemical parameters of oral fluid.

Materials and methods. The study involved patients aged 18 to 22 years who are undergoing orthodontic treatment with a bracket system. Thegroup of examined persons was 25 people. The control group included 15 practically healthy people without braces. All patients underwent dental status assessment (Green – Vermillion hygiene index – simplified IG-Y; PMA inflammation index), laboratory examination of oral fluid before and after controlled oral hygiene. The biochemical analysis included determination of the acid-base balance in the oral fluid using a pH meter, assessment of free radical oxidation by chemiluminogram parameters by biochemiluminescence and by levels of molecular products of lipid peroxidation (diene and triene conjugates, Schiff bases), activity of the enzyme alkaline phosphatase, concentrations of total protein and lactate.

Results and discussions. In patients undergoing orthodontic treatment with a bracket system, an insufficient level of oral hygiene and inflammatory manifestations in the gums of moderate severity were revealed. The level of the acid-base balance of the oral fluid before controlled hygiene was equal to 6.8±0.19, that is, below the range of normal pH values in the oral cavity. After hygiene, the pH of the oral fluid returned to the norm of 7.1±0.2. In patients with braces, activation of free radical oxidation and an increase in lipoperoxidation parameters – triene conjugates and Schiff bases, increased activity of alkaline phosphatase, total protein and lactate levels took place.

Cоnclusion. After hygienic treatment of the oral cavity, the biochemical parameters did not differ statistically significantly from the control data.
Features of endodontic treatment of teeth with curved root canals according to a survey of dentists
Authors: Rasskazov I. Y. , Makeeva M. K. , Karnaeva A. S. , Makhmudova Z. K. , Kozhevnikova L. A. , Pilshchikova O. V.
Published: November 2024

Purpose: to identify difficulties of endodontic treatment of teeth with curved root canals according to a survey of dentists.

Materials and methods: 90 dentists (26 men, 64 women) participated in the survey. 68 people had a therapeutic certificate, 19 people had an orthopedic certificate, 10 people had a surgical certificate, 6 people had a certificate in pediatric dentistry, and 43 people had a certificate in general dentistry (some respondents indicated that they had several certificates). The average age of respondents is 32 years (23–60). The interviewed dentists conduct practical work in public medical institutions, private dental clinics, and rented offices. The questionnaire included 20 questions (6 questions were aimed at collecting demographic data, 14 questions were aimed at obtaining information about the treatment of teeth with curved root canals). The questionnaire was submitted electronically to Google Forms. Statistical analysis of conjugacy tables using the Pearson chi-square test was performed using the program StatTech (Russia).

Results: this survey reliably showed that dentists often experience difficulties in treating teeth with curved root canals. Dentists working in state institutions are significantly more likely to note that the rubberdam latex interferes (p= 0.049) and the clamp bow (p= 0.029) compared to doctors working in other institutions. Dentists working in a rented office are significantly more likely to report that a rubberdam latex interferes (p= 0.024) compared to doctors working in other institutions. Dentists who report difficult access when working with the mesial buccal canal of the lower molars are significantly more likely to note that a rubberdam latex interferes (p= 0.036). Dentists who use the approach «first negotiation to the working length – then coronal flaring» significantly more often experience difficulties when working with the mesial buccal first canal of the upper molars

. Conclusions: the results of the survey demonstrated a number of differences in the performance of endodontic treatment of teeth with curved root canals. Based on the survey, statistically significant relationships were identified between some work features and difficulties encountered by doctors at the stages of treatment.