bluuebunny/crossref_metadata_2025 huggingface dataset:
Students’ Perception of Their Self-Efficacy by Being a “Hey Peer Educator” in Drug Abuse Prevention
Authors: Nurmala Ira , Salim Lutfi Agus , Muthmainnah Muthmainnah , Devi Yuli Puspita , Harris Neil , Wiseman Nicola , Nadia Asma
Published: September 2024

Background: Peer education programs provided in schools are one method to help prevent drug abuse; however, the effectiveness of these programs relies, in part, on their delivery to the population in need. Therefore, the effectiveness of the program relies on the self-efficacy of peer educators. The peer education program helps students to practice their skills as peer educators in avoiding drug abuse. Aims: This study aimed to explore the students’ self-efficacy as peer educators after being a peer educator in the peer education program. Methods: In-depth semi-structured interviews were conducted with 45 student peer educators in Middle schools located in Surabaya, Indonesia. Results: Adolescents who acted as student peers perceived and experienced an improvement in their knowledge and ability to help their peers avoid drug abuse. Conclusion: The peer education program is perceived to improve students’ self-efficacy in counseling tasks, to learn analytical skills, and to maintain positive behavior.
Mitigating Stunting in Semarang City, Indonesia: A Comprehensive Approach to Better Health and Well-Being
Authors: Krisseptiana  , Martadi Nana Storada Dwi
Published: September 2024

Background: Among the 29 districts and 6 cities in Central Java, Semarang City stands out as the urban area with the most substantial reduction in stunting prevalence over a year (2021-2022), from 21,3% to 10.4%, while numerous regions continue to grapple with challenges in lowering rates of stunting. Aims: This study aims to investigate Semarang City's comprehensive strategy for mitigating stunting. Methods: This study used a qualitative case study approach. Utilizing focus group discussions (FGD) and document analysis, representatives from 16 diverse sectors, including health, education, religion, social services, food security, and more, engaged in discussions to synchronize activities and policies to achieve the common goal of stunting reduction. Simultaneously, a comprehensive document analysis was conducted, reviewing relevant documents, reports, and policies across 16 districts in Semarang City. Data analysis employed Miles et al.'s interactive model, involving data condensation, display, and conclusion drawing/verification. Results: The success of stunting reduction in Semarang City is highlighted by relevant regulations, an updated and accurate statistical database, intensive cross-sector coordination, and a synchronized effort across diverse sectors. Furthermore, the city's prudent financial planning is evident through sufficient and on-target budget allocations dedicated to stunting reduction programs. Conclusion: The research the importance of ongoing commitment, adaptability, and collaborative efforts to achieve the ambitious goal of zero stunting by 2024 in Semarang City, suggesting future studies focus on program effectiveness and long-term sustainability.
Self-Esteem among Men Who Have Sex with Men Living with HIV: A Qualitative Study
Authors: Linlin Lindayani  , Ridzki Melinda Patricia , Purnama Heni
Published: September 2024

Background: HIV transmission in males, particularly in Indonesia, is increasing due to increased sexual activity among Men who have Sex with Men (MSM) groups. This is largely due to diminished self-esteem and reluctance to disclose their status, influenced by factors like power, virtue, relevance, and competence. Aims: The study investigates the self-esteem of MSM living with HIV and explores the factors that may influence their self-esteem. Methods: This study employs a descriptive qualitative study. The study used interviews and content analysis techniques to gather data on HIV individuals at the Public Health Center, specifically focusing on MSM. Results: The interview data revealed six themes: individualism, body image dissatisfaction, lack of motivation, lack of peer support, aspiration to be useful, and self-esteem needs. Conclusion: The study reveals that self-esteem in HIV-positive men is influenced by coping strategies, body image dissatisfaction, motivation, and peer support. It suggests helping others and enhancing library resources, regular investigations, and a specialized counseling program to improve self-esteem.
Direito e modernidade: as regras jurídicas como engendramento da exacerbação do individualismo e do subjetivismo
Authors: Morais Manoel dos Reis
Published: September 2024

O artigo é uma investigação sobre as categorias Direito e Modernidade, com o objetivo de demonstrar o que é que subjaz às mutações do Direito ao longo do tempo, assumindo como hipótese a exacerbação do individualismo e do subjetivismo que foram instaurados na Modernidade.
A legislação brasileira de tributação de lucros auferidos por controladas no exterior: momento para mudanças
Authors: Ribeiro Marques Fernandes Tarsila
Published: September 2024

O presente artigo apresenta o atual regime de tributação dos lucros auferidos no exterior por empresas controladas, previsto nos artigos 76 a 91 da Lei 12.973/2014, objeto de recentes alterações. Referida legislação tem como característica marcante o fato de tributar uma renda que não foi efetivamente distribuída para a sociedade brasileira relacionada e que ainda se localiza no exterior. Esse tipo de legislação é conhecido na seara internacional tecnicamente como legislação CFC (controlled foreign company legislation). Por lidar com presunções, trata-se de tema complexo e extremamente controverso tanto no âmbito interno quanto internacional. O artigo fornece uma análise crítica do atual regime brasileiro de CFC e aponta os aspectos da referida legislação que deveriam ser objeto mudanças a fim de não prejudicar a competitividade das empresas brasileiras quando atuam internacionalmente.
La réforme fiscale : une opportunité pour le développement urbain au Brésil
Authors: Fuchs-Cessot Alice , Vieira da Costa Tupiassu Merlin Lise , Soeiro Vieira Bruno , De Lourdes Teixeira Vieira Iracema
Published: September 2024

Dès lors qu’il est du devoir du gouvernement municipal de promouvoir la planification du développement urbain de sorte que les villes soient des lieux qui favorisent la dignité, cette recherche est ratifiée, dont l’objectif général est d’évaluer si le projet de réforme fiscale en cours au Congrès national a le potentiel de générer des changements positifs dans l’ordre urbain-environnemental brésilien. Ainsi, grâce à la méthodologie qualitative et aux techniques bibliographiques et documentaires, il a été possible d’analyser l’état de l’art, la PEC nº 45-A et les objectifs de l’objectif 11 des ODDs. Il est apparu clairement que le texte de la réforme fiscale a le potentiel de transformer le modèle de construction de villes conformément aux objectifs de l’Agenda 2030. Cependant, la fenêtre d’opportunité du changement dans la politique urbaine dépendra de la compréhension politique et entrepreneuriale pour garantir des villes inclusives, sûres, résilientes et durables.
Estado de Bienestar, desigualdad y calidad democrática: análisis de las motivaciones detrás de las políticas públicas
Authors: Fernández Álvarez Antón Lois
Published: September 2024

As democracias liberais aspiram proporcionar elevados padrões de bem-estar aos seus cidadãos e aparecer como sistemas representativos consolidados, com qualidade democrática. Para tal, e com importância crescente devido aos efeitos da globalização, o combate à desigualdade surge como elemento substancial e integrador dos Estados de bem-estar. Para fortalecer a igualdade, ou a tendência para ela, são essenciais políticas públicas voltadas para o bem-estar. Neste estudo, investigaremos os conceitos de Estado de bem-estar social, desigualdade e qualidade democrática, para examinar as motivações que fundamentam os poderes públicos na adoção de determinadas políticas. Utilizaremos o método dedutivo aplicado às ciências sociais e a abordagem qualitativa, com a formulação de duas hipóteses, com o propósito de identificar os motivos que inspiram as políticas públicas em geral e as políticas sociais em particular.
Macro-TSH: A Diagnostic Dilemma
Authors: Işıklar Özben Özden , Elifoğlu İlknur , Baş Veysel Nijat
Published: September 2024

Macro-TSH, nadir görülen bir laboratuvar interferansı olup özellikle pediatrik hastalarda tanı açısından zorluklar oluşturur. Bu yazıda, hipotiroidizm belirtileri olmaksızın yüksek tiroid uyarıcı hormon (TSH) seviyeleriyle karakterize edilen makro-TSH’lı 5 yaşındaki bir erkek hastanın vakası sunulmaktadır. Normal serbest tiroksin (fT4) seviyelerine rağmen, klinik bulgular ile TSH seviyeleri arasındaki uyumsuzluk daha fazla araştırmayı gerektirmiştir. Polietilen glikol (PEG) ile işlenen serum örnekleri, TSH seviyelerinde belirgin bir azalma göstermiş ve makro-TSH varlığını doğrulamıştır. Bu vaka, TSH ve fT4 seviyeleri arasında uyumsuzluk olduğu durumlarda klinik ve laboratuvar bulgularının dikkatli bir şekilde değerlendirilmesinin önemini vurgulamaktadır. Makro-TSH'nin tanınması, gereksiz tetkik ve tedavilerin önlenmesine ve böylelikle hastaların yönetiminde iyileşmeye yol açabilir.
Marmara Bölgesinde Yaşayan Atopik Çocukların Aeroalerjen Duyarlılıklarının Değerlendirilmesi
Authors: Akçal Ömer , Atakul Gizem
Published: September 2024

Marmara bölgesinde yaşayan ve atopik yakınmalar ile kliniğimize başvurmuş hastaların aeroalerjen duyarlılıklarının dağılımını incelemek istedik. Çocuk İmmünolojisi ve Alerji Hastalıkları Polikliniği’ne Nisan 2023-Nisan 2024 tarihleri arasında başvuran 0-18 yaş arası hastalardan deri prickprik test (DPT) uygulanmış olgular geriye dönük olarak değerlendirildi. Olguların % 40,2’ si (n=355) nonsensitize, % 46,2’ si (n=408) monosensitize, % 13,6’ sı (n=120) polisensitize idi. Olgularımızda en sık (% 44,3) saptanan aeroalerjen ev tozu akarlarıydı. Bunu sırasıyla polen, hayvan tüyü epiteli ve küf takip ediyordu. Alerjik hastalıklarda primer korunma önlemleri tedavinin ilk basamağını oluşturmaktadır. Bu bölgede yaşayan olgularda en sık aeroalerjenin bilinmesi duyarlanma öncesinde bile farkındalık sağlamaktadır. DPT için alerjen paneli oluşturulurken bölgeye özgü duyarlılık sıklığı mutlaka göz önüne alınmalıdır.
Research progress on the role and mechanism of circular RNA in drug resistance of head and neck squamous cell carcinoma
Authors: Zeng Hongli , Ge Junshang , Meng Yi , Wang Qian , Yang Mei , Zeng Zhaoyang , Xiong Wei , Zu Xuyu
Published: September 2024

Drug resistance in tumors constitutes a significant obstacle to tumor therapy. Head and neck squamous cell carcinoma (HNSCC) presents a major challenge due to its deep anatomical location, limited space, and complex structure. These factors complicate surgical procedures and hinder the effectiveness of chemoradiotherapy, leading to poor prognosis and reduced quality of life. However, there is hope in the form of circular RNAs (circRNAs), non-coding RNA molecules with a closed-loop structure that exhibits superior stability and resistance to degradation compared to linear RNAs. Recent advances in high-throughput sequencing and bioinformatics technology revealed that circRNAs participate in tumor proliferation, invasion, migration, and drug resistance. This review aims to summarize current research progress on the involvement of circRNAs in drug resistance of HNSCC and provide valuable insights for the prevention and mitigation of drug resistance in HNSCC.
Promotion with digital media on the purchase decision of Paguh Rice
Authors: - Veronika -
Published: September 2024

Rice commodity becomes a challenge in online marketing. Given that rice is generally sold directly. This study aims to determine the effect of promotion and analyze the effectiveness of media promotion on digital media (facebook and instagram) of Beras Paguh with the AIDA model (Attention. Interest, Desire, and Action). The survey method was used for 100 respondents in Pontianak City by purposive sampling. Data was collected through an online questionnaire via google form. The data analysis technique used Structural Equation Modeling (SEM) through LISREL 8.80 software and the average score and simple tabulation. SEM is used to analyze the effect of digital media promotion of Paguh Rice with the AIDA model. Then the average score and simple tabulation were used to analyze the effectiveness of Paguh Rice digital media promotion. The results show that Attention and Interest have a positive effect on purchasing decisions for Paguh Rice with the most influenced indicator, namely messages, where the better the message design on digital media will be followed by higher purchasing decisions. Then in the calculation of the average score, the data shows that online promotion is quite effective on consumer purchasing decisions. This can be seen from the average value generated, which is 3.29. With this value, the promotion is declared quite effective because it is in the range of 2.61-3.40. This shows that the effective use of promotions implemented by Paguh Rice is due to the use of media that is in accordance with consumer needs and based on uploads that can attract attention until consumers finally decide to buy the product.
UPAYA PENGEMBANGAN USAHA SALE PISANG JANNAH CILACAP BERDASARKAN TINGKAT KEPENTINGAN DAN KEPUASAN KONSUMEN
Authors: Mela Ervina , Masitoh Monalisa , Handayani Isti
Published: September 2024

Usaha Mikro, Kecil, dan Menengah JANNAH merupakan perusahaan yang memproduksi sale pisang. Perusahaan ini masih memiliki beberapa kendala dalam hal produksi, distribusi, promosi, dan pemasaran. Penelitian ini bertujuan untuk mengetahui atribut yang perlu diperbaiki dan menentukan strategi perbaikan produk sale pisang JANNAH. Penelitian dilakukan dengan kuesioner yang disebarkan secara purposive sampling dan hasil penelitian dianalisis menggunakan Importance Performance Analysis (IPA) dan Causal Loop Diagram (CLD). Hasil penelitian menunjukkan, atribut yang menjadi prioritas perbaikan adalah informasi yang tertera pada label kemasan, promosi dan pemasaran melalui media sosial, kemudahan dalam memperoleh produk, dan kemampuan kemasan dalam melindungi produk. Strategi perbaikan yang direkomendasikan antara lain mengikuti penyuluhan atau pelatihan mengenai label kemasan pangan, mengubah desain label kemasan dengan menambahkan informasi yang belum ada, mengikuti penyuluhan atau pelatihan pemanfaatan media sosial sebagai alat pemasaran, memanfaatkan fitur-fitur pemasaran yang terdapat pada Facebook dan WhatsApp, menggunakan alat pemasaran online lainnya, melakukan edit gambar produk, menyusun copywriting, membuat jadwal promosi, membuat konten promosi yang beragam, memaksimalkan kapasitas produksi saat cuaca terik, bermitra dengan pemasok pisang lainnya, menerapkan teknologi tepat guna pada alat penjemuran, bermitra dengan warung atau toko lainnya, mengikuti penyuluhan atau pelatihan penggunaan marketplace, membuat dan mengelola akun marketplace secara aktif, menerapkan sistem pengawasan mutu terhadap kemasan, dan mengganti kemasan dengan standing pouch berwarna yang dilengkapi dengan jendela/window.
ANALISIS KELAYAKAN DAN KONTRIBUSI USAHA AGROINDUSTRI SIRUP PALA (Myristica fragrans) TERHADAP PENDAPATAN RUMAH TANGGA KECAMATAN TAPAK TUAN KABUPATEN ACEH SELATAN
Authors: Puarada Sakral Hasby , Gurning Riris Nadia Syafrilia , Utami Dewanti Risa
Published: September 2024

Industri pertanian memiliki peran penting dalam meningkatkan pendapatan dan kesejahteraan masyarakat pedesaan. Penelitian ini membahas kontribusi usaha agroindustri sirup pala (Myristica fragrans) terhadap pendapatan rumah tangga di kecamatan Tapak Tuan Kabupaten Aceh Selatan. Metode penelitian menggunakan studi kasus (case study). Penulis mengambil semua populasi pelaku agroindustri sirup pala yaitu 20 orang. Untuk Menganalisis permasalahan pertama menggunakan metode deskriptif kuantitatif yakni, Return Cost Ratio (R/C Ratio). Untuk Menganalisis masalah kedua menggunakan deskriptif dengan menghitung pendapatan agroindustri sirup pala (Rp/bulan) dan pendapatan total rumah tangga (Rp/bulan). Rata-rata jumlah produksi sirup pala perbulannya adalah 404,4 botol, dengan harga sirup Rp.15.000/botol, dengan penerimaan Rp.6.066.000 per bulan. Didapatkan bahwa nilai R/C sebesar 2,58 dengan interpretasi bahwa usaha agroindustri sirup pala layak untuk diusahakan. Nilai B/C terdapat sebesar 1,75 dengan demikian dapat dikatakan layak dengan interpretasi penambahan biaya Rp.1 maka akan menguntungkan sebesar Rp.1,75. Nilai BEP Harga sebesar Rp 5.793,40 dan BEP Produksi 12 botol serta BEP Penerimaan sebesar Rp.119.830,67. Berdasarkan hasil dapat disimpulkan rumusan masalah pertama yaitu usaha agroindustri sirup pala di lokasi penelitian dikatakan layak berdasarkan kriteria R/C, B/C, BEP harga, BEP produksi, dan BEP penerimaan. Dalam keseluruhan, agroindustri sirup pala berpotensi signifikan dalam meningkatkan pendapatan rumah tangga dan berkontribusi pada pembangunan ekonomi lokal.
Analyzing the Impact of the Pandemic on Indonesia’s Economic Growth Using Dynamic Time Warping
Authors: Primandari Arum Handini , Kusuma Arum Widya
Published: September 2024

Asia’s GDP experienced the most drastic decline during the COVID-19 compared to other economic crises. This study collected data on economic indicators for each province/city to observe economic growth in Indonesia, such as Gross Regional Domestic Product (GRDP), unemployment rate, and economic growth. The clustering method on time series data found several provinces/cities with similar economic growth patterns to observe the pandemic's impact on their economies. Knowing the pattern of economic growth will help the regulation holder support provinces with the right policy. For this purpose, we utilized the Dynamic Time Warping (DTW) distance with the k-medoids procedure. The DTW is an algorithm for measuring the similarity between two temporal sequences. The clustering of the three economic indicators had three clusters with the most optimal validation index. Each cluster had almost the same pattern since the trend tended to increase from before the pandemic and then decrease during the pandemic. The decrease in GRDP was less significant than the minimal data on GRDP that happened before the pandemic. Most provinces had negative economic growth during the pandemic, which skyrocketed even for the first quarter of 2023, almost the same as before the pandemic.
Maximizing Production Within Integrated Facilities Through Flow Re-Routing and Backpressure Management
Authors: Muhammad Hazwan Afiq Zulhaimi
Published: September 2024

This paper illustrates how understanding facility limit, managing topside system pressures as well as optimizing product flow routing in an integrated oil-gas-condensate facility complex for mature fields are key to protecting and further optimizing base volumes while enabling volume gains from new wells. Low-cost and reliable execution of surface modifications via control valve, choke reinstatement and well mix optimization with strong integrated subsurface-surface network understanding are key ingredients in identifying and realizing the value from a potential unoptimized network.

In a mature integrated oil-gas-condensate facility complex, understanding the facility limits, flow network and remaining subsurface potentials production profiles are crucial in finding ullage for flow routing optimization and back pressure management. The evaluation includes the use of integrated network simulator and wellbore hydraulic model software application on potential gains from system pressure reduction; followed by assessments to address subsurface-surface uncertainties from the existing network comprising Oil and Non-Associated Gas wells, and impact to network well mix and Gas lift optimization.

Well level performance from well tests, network level performance from platform to separator outlet, gas lift and key surface equipment e.g., separators, pipelines and compressors history were some of the information used for the evaluation. The evaluation recommends splitting oil and gas wells to prevent backpressure impact, optimize the system pressures and utilize the full ullage of the integrated network gas compressor. Based on actual observation, the system pressure reduced by 26% which results in 8% of incremental oil gain.

The integrated network simulator model recommends reduction of gas lift consumption, selective wells to shut in and choke down as we add more wells into the network to manage backpressure impact. Gas lift header pressure controls and well production chokes were reinstated and resized appropriately to enable production optimization. As a result, about 9% of total oil production was recovered from the optimized network, and a further 3% increase was observed from new wells post-network optimization.

This paper will illustrate the challenges in a 40-year-old complex integrated network facility, with combinations of oil, non-associated gas and gas cap blow down production and approaches taken to address the challenged and continue to maximize overall production
Synergistic Enhancement of Partially Hydrolyzed Polyacrylamide and Treated Palm Oil Fuel Ash for Enhanced Oil Recovery
Authors: Kachoyan S. , Zoveidavianpoor M. , Khanifar A.
Published: September 2024

Polymer flooding, a widely adopted technique for enhanced oil recovery, often relies on partially hydrolyzed polyacrylamide (HPAM). Despite its proven efficacy, HPAM faces challenges in hightemperature, high-salinity reservoirs. To address these limitations, this research explores the utilization of palm oil fuel ash (POFA), a byproduct generated from burning palm fibers and shells for electricity in mills. This sustainable additive aims to enhance the thermal stability, salt resistance, and mechanical robustness of HPAM. Laboratory experiments were conducted to evaluate the feasibility of incorporating POFA alongside HPAM, with a focus on cost-effectiveness and environmental friendliness. This study marks the pioneering utilization of POFA as an additive, introducing an innovative solution to mitigate the shortcomings of HPAM and advance polymer flooding efficiency in challenging reservoir conditions. POFA underwent washing, drying, grinding, and sieving to produce untreated POFA (UPOFA), followed by treatment involving heating at 900°C for 120 minutes to obtain treated POFA (TPOFA). Both ashes were characterized by means of particle Size Analysis (PSA), Zeta Potential (ZP), Fourier transform infrared spectroscopy (FTIR), Field Emission Scanning Electron Microscopy (FESEM) and Energy Dispersive X-ray Analysis (EDX), and Thermogravimetric Analysis (TGA). Rheological properties, wettability, Interfacial Tension (IFT), and flooding experiments were conducted to assess the impact of adding both ashes to HPAM and a polymeric solution. The characterization results reveal a 1.6% enhancement in specific surface area for TPOFA, improved zeta potential by 8%, altered vibrational spectra, transformed surface morphology, and enhanced chemical composition post-thermal treatment. Rheological testing showed superior stability for HPAM/TPOFA, exhibiting robust intermolecular interactions. HPAM/TPOFA improved wettability and provided stronger water-wetting. Also, the novel mixture exhibited superior stability at elevated temperatures (up to 80°C), and high salinities (30,000 ppm) compared to pure HPAM. This enhanced stability could be attributed to strong intermolecular interactions between HPAM and TPOFA molecules. TPOFA effectively reduced IFT at the crude oil-water interface, and in oil displacement experiments, HPAM/TPOFA achieved the highest recovery (65% OOIP), showcasing its potential as an effective additive for EOR processes. This innovative hybrid of HPAM/TPOFA is designed to address the shortcomings associated with HPAM and improve its performance in challenging reservoir conditions using renewable resources.
Elevating Reservoir Performance in Mature Assets Through Strategic Memory Perforation Execution for Optimization
Authors: Julian F. , Ismail S. Syed , Ismail N. A. , Subandi A. Ahmad , Hao T. Shuo , Nadarajan S. , Yahaya W. , Ismail N. , Hamzah S. , Mokhtar A. , Goh B. , Drahaman V. , Wong L.
Published: September 2024

The Malay basin located offshore Terengganu, Malaysia, is a prolific hydrocarbon-producing region with the very first exploration well drilled in 1969. Since then, numerous fields have been discovered and developed. Thinly bedded and laminated sandstone have been recognized as a significant theme of clastic reservoirs in the Malay basin that may contain substantial hydrocarbon accumulations.

Commingled completion strategies are commonly employed to optimize well configurations, combining zones of high-quality reservoirs with those of lower-quality laminated sands. This approach while simplifying well design, inadvertently causes ‘preferential fluid movement’. As a result, hydrocarbons tend to migrate through the higher permeability zones of the superior quality reservoirs, leaving behind ‘bypassed’ hydrocarbon in the lower permeability zones of the laminated sandstones. Without targeted mitigation, this practice leads to generally suboptimal development and depletion plans for laminated sand. Recent infill drilling programs observed the presence of bypassed and unswept hydrocarbons in laminated sandstone, even in fields with over 30 years of production history. Oil in high-quality, homogeneous reservoirs typically exhibits complete or near-complete sweep due to excellent lateral and vertical permeability. In contrast, oil in sand-shale laminated formations tends to be preferentially swept, highlighting the need for strategic well placement to ensure optimal resource extraction.

Application of memory perforation, particularly in the context of oil and gas operations, is a cost-effective technique often applied in mature assets to enhance production and achieve higher returns. Despite its advantages, there are several challenges to be addressed to improve the effectiveness of the execution and minimize potential failure. These challenges include:
Paradigm Shift in Well Intervention: Novel Approach Utilizing Instrumented Coiled Tubing to Convey the Longest Expandable Straddle Packer for Selective Cleanout and Water Shut-Off in Horizontal Inflow Control Devices Completion - A Story of Success in West Kuwait
Authors: Slama Mohamed Hedi , Mijdad Mohamed Bu , Badrawy Kareem , Sunagatov Rustem , Sebaih Mohannad Adel , Fajardo Sergio Rondon , Mosbah Mohamed Taher , Nayef Al Ajmi Abdulaziz , Al Hajji Ahmad , Pochetnyy Valentin , Baiej Osama
Published: September 2024

This study describes the remarkable milestone that has been achieved in West Kuwait with a first-of-its kind job worldwide, where an innovative approach to selective cleanout and water shut-off (WSO) intervention was executed. This involved the use of expandable straddle packers and instrumented coiled tubing (CT) downhole measurement system in a well completed with 5 ½-in horizontal passive inflow control devices (ICDs) in a long sandstone reservoir section.

The subject well encompassed a total of 48 passive ICDs, spread out across 16 ICD compartments, each of the compartment intercepts one, three or four ICDs isolated by swellable packer on the openhole side. Based on the recent production logging tool (PLT) interpretation, the middle reservoir section of 6 compartment is deemed to produce water whereas the bottom part of the reservoir has got a good oil contribution adding hence some complexity on the water-shut off design. To address this intricacy, the straddle packer assembly, which conveyed via instrumented CT, has a remarkable space out of 110 ft between the sealing elements, making it the longest straddle packer conveyed with CT used in the world. The expandable, re-settable, and configurable packer’s elements allowed precise injection of cleanout and WSO treatment in one run and worked on pump rates and accurate placement to operate under different configurations. This innovative approach eliminated the need for multiple plugs to isolate different wellbore sections, while reducing the time of operation execution.

Real-time downhole measurement capabilities played a significant role in the success of the intervention. CT internal pressure, annulus pressure, annulus temperature, and axial force were used to ensure a more accurate fluid placement across the desired ICD compartments. The combination of expandable straddle packers and real-time downhole measurement system enabled rapid response and adjustments to the actual downhole conditions throughout the intervention, resulting in a significant drop in produced water from 90% to an average of 60%, while oil production remained steady.

This pioneering case study is a testament to how the integration of CT, downhole live telemetry, and mechanical wellbore multi-set isolation tools can push the boundaries of well intervention to enhance production in wells with challenging configurations. The innovative approach, which reduced the time of operation execution and ensured the treatment chemical fluids were used in a cost-effective manner, demonstrates the potential for improving productivity of other wells with passive ICD configuration.
Lessons Learned of Dual Monobore Completion Well Construction
Authors: Suprihono Sanny
Published: September 2024

Selection of the completion type of a well is based on many factors. Some factors are main justification to select dual monobore completion well for the field development. Excellent conceptual, planning and preparation stages would bring successful well execution. Overall, the well design was executed successfully. However, some lessons learned remain to improve the future well completion execution that to be discussed in this paper. There are four wells completed with dual monobore completion in this project phase.

Well completion selection process selected dual monobore completion with the last tubing size is 3-1/2 inch. Some of main factors to apply dual monobore in this field are: many sand gas zones, higher gas rate with dual production strings, remote area with high cost for any work-over operation for changing layer. Any future well intervention will be performed with rigless, wireline operation or coil tubing unit as required. Another new procedure of getting underbalanced condition before perforation is by pumping diesel oil as the last fluid into tubing. This avoids unloading operation with coil tubing unit which costly in remote operation.

After drilling and setting the 7 inch production liner below the 9-5/8 inch casing, long string & short string of 3-1/2 inch tubing run together with specific tubing tong. Cement unit pumped cement to surface through the long string to cover all tubing length, however about 20 ft of cement at surface circulate out by inserting small macaroni string, to be able to set pack off seal between tubing and well head, which specifically designed for dual monobore tubing installation. The operation continued with rigless operation for cement log, perforation and flowing the well.

Some problems for lesson learned were tubing tong gripping problem, tubing cementing head leaking, tubing restriction inside tubing that near the bottom of the lowest zone perforation, high over pull of the slickline unit, orienting gun perforation length limitation.

Mostly the designs of the dual monobore completion were successfully implemented in this project. The cementing operation performed well. Double casing perforation is achieved with the depth penetration gun. Both tubing strings could produce gas as expected. Diesel oil successfully displaced the cement, gave under balanced perforation and returned back to surface on flowing. The dual monobore completion will be applied for the future well campaign.
Comparative Analysis for selection of best methodology in determining the lean enabled supply chain agility: An AHP & fuzzy SWARA-WASPAS based approach
Authors: Sharma Hemant , Sohani Nagendra
Published: September 2024

Almost all the manufacturing organizations today needs such a supply chain network which is efficient as well as responsive to optimize their lead time by quick supply along with cheap cost. This could be done either by the adoption of lean strategy which focuses on efficient supply chain enhancement, or the adoption of agile strategy, the primary objective of which is to enhance responsive supply chain. But as seen in most of the manufacturing organizations, their range of products are meant for different categories of customers which starts from low cost to high cost. As per the market study the positioning of the product highly depends upon the differentiation of the customers which leads to the best strategy as per the leaverage of both lean & agility. So adoption of either of the strategy alone is not the best idea to fulfill their objective, while the adoption of a combination of both strategy partially could fulfil their requirement, the concept is termed as leagile supply chain. In this paper the authors has investigated & identified 28 lean enablers, 11 agile factors which are highly responsible to affect any supply chain specially focusing of automobile sector. Apart from above 9 leagile enablers were also identified in the paper. After that few methodologies among many of the Multi-criteria decision making (MCDM) are adopted to find the ranking as well as some interrelationships among the identified enablers or factors. The innovation in the paper is that the authors has proposed the fuzzy SWARA-WASPAS based approach for determining the role of lean in enabling the supply chain agility. Also in continuation the AHP methodology is applied to find the priority weightage & ranking of leagile enablers.Finally the comparative analysis has been done in the results obtained by both the applied strategies to have a more clear picture for the stakeholders, whether to adopt any of them as per the customized requirement of their supply chain.
Improving thermostability of salt-tolerant xylanase from Hortaea werneckii EXF-12619 by N-terminal replacement and C-terminal carbohydrate binding module fusion
Authors: Zhang Huifang , Cai Qinzhou , Long Yating , Li Jiajun , Pan Siyu , Yonghua Wang
Published: September 2024

Xylanase from glycoside hydrolases family 11 (GH 11) is widely applied because of their substrate selectivity and broad optimal pH. However, higher thermostability is always preferred in addition to other stress tolerance of the enzyme. Therefore, we first expressed and characterized a novel GH 11 xylanase from Hortaea werneckii (HWxyn11) tolerant to NaCl and extreme pH conditions although still unsatisfied thermostability. To achieve better thermostability, we then constructed mutants by applying N-terminal replacement or C-terminal carbohydrate binding module (CBM) fusion, considering that thermostability of GH 11 xylanase could be affected by structural differences between N-terminus and C-terminus significantly. The combined mutant HWxA31-CBM 6 had increased thermostability than that of HWxyn11. Molecular dynamics simulation analysis reveals that the N-terminal replacement or C-terminal CBM fusion resulted in declined flexibility, indicating the improvement of structural rigidity and thermostability. Structural analysis confirms that the removal of N-terminal propeptide and the fusion of CBM contributed to improved thermostability. Our findings prove that the combination of replacing N-terminal sequences and fusing with CBMs from thermophilic xylanases contributed to declined structural flexibility, providing a practicable method to improve the thermostability of GH 11 xylanases.
Interaction of 1-hexyl-3 methylimidazolium bromide ionic liquid with methylparaben drug
in aqueous solution: Conductometric and molecular dynamics studies
Authors: Gilandooz Roghayeh Darvishi , ghalami-choobar bahram , Mashatooki mohaddeseh habibzadeh
Published: September 2024

In this research, the thermodynamic properties and molecular interactions of 1-hexyl-3-methylimidazolium bromide + methylparaben + water system were reported using conductometric method and molecular dynamics simulations. The conductometric data were collected for ionic liquid from 0.0012 to 0.1983 mol.kg− 1 on various molality of methylparaben in aqueous solution (mMP = 0.0000, 0.0005 and 0.0010 mol.kg− 1) at T = (300.2, 310.2 and 320.2) K and P = 0.1 MPa. Fuoss-Onsager equation was applied to get the ion association constants and limiting molar conductivities of ionic liquid and to determine the thermodynamic of ion association. Moreover, molecular dynamics simulations were made to understand the interactions between ionic liquid and methylparaben at the molecular and microscopic level. Radial distribution functions, root mean square deviations, hydrogen bonding and van der Waals and EL interactions were obtained. Furthermore, the diffusion coefficients of ionic liquid in methylparaben and water mixtures were obtained from MD simulation to calculate the molar conductivity of HMIm]Br using Einstein's Nernst equation at T = 310.2 K and were in agreement with experimental molar conductivity.
Analysis of Factors Affecting Urban Land Use Changes: A Case Study of Urmia City, Iran
Authors: Ziari Keramatollah , Kay Shahriar Hamidi , Qelichi Mohamad Molaei
Published: September 2024

The intricate relationship between human activities and the natural environment has a profound impact on land use patterns. These changes, whether direct or indirect, often lead to a myriad of environmental challenges that jeopardize the well-being of our planet. Therefore, understanding the nature of these transformations and the factors driving them is crucial for ensuring the sustainability of life and mitigating the adverse effects of land use changes. This research adopts an applied approach and follows an exploratory methodology. To identify land use changes, satellite imagery from the years 1993, 2003, 2013, and 2023 was analyzed using the ENVI, GIS, and Google Earth software. The study area encompasses the city of Urmia and its surrounding areas, covering a total of 26,768.7 hectares. The findings reveal a dynamic pattern of land use changes over the three decades from 1993 to 2023.
Machine Learning Computed Tomography Radiomics of Abdominal Adipose Tissue to Optimize Cardiovascular Risk Assessment
Authors: Mancio Jennifer , Lopes Alice , Sousa Inês , Nunes Fabio , Xara Sonia , Carvalho Mónica , Ferreira Wilson , Ferreira Nuno , Barros Antonio , Fontes-Carvalho Ricardo , Ribeiro Vasco Gama , Bettencourt Nuno , Pedrosa Joao
Published: September 2024

Background
Subcutaneous (SAF) and visceral (VAF) abdominal fat have specific properties which the global body fat and total abdominal fat (TAF) size metrics do not capture. Beyond size, radiomics allows deep tissue phenotyping and may capture fat dysfunction. We aimed to characterize the computed tomography (CT) radiomics of SAF and VAF and assess their incremental value above fat size to detect coronary calcification.
Methods
SAF, VAF and TAF area, signal distribution and texture were extracted from non-contrast CT of 1001 subjects (57% male, 57 ± 10 years) with no established cardiovascular disease who underwent CT for coronary calcium score (CCS) with additional abdominal slice (L4/5-S1). XGBoost machine learning models (ML) were used to identify the best features that discriminate SAF from VAF and to train/test ML to detect any coronary calcification (CCS > 0).
Results
SAF and VAF appearance in non-contrast CT differs: SAF displays brighter and finer texture than VAF. Compared with CCS = 0, SAF of CCS > 0 has higher signal and homogeneous texture, while VAF of CCS > 0 has lower signal and heterogeneous texture. SAF signal/texture improved SAF area performance to detect CCS > 0. A ML including SAF and VAF area performed better than TAF area to discriminate CCS > 0 from CCS = 0, however, a combined ML of the best SAF and VAF features detected CCS > 0 as the best TAF features.
Conclusion
In non-contrast CT, SAF and VAF appearance differs and SAF radiomics improves the detection of CCS > 0 when added to fat area; TAF radiomics (but not TAF area) spares the need for separate SAF and VAF segmentations.
Comparative the efficacy and safety of Gosuranemab, Semorinemab, Tilavonemab, and Zagotenemab in patients with Alzheimer's disease: a systematic review and network meta-analysis of randomized controlled trials
Authors: Cai Wenting , Zhang Hui , Wu Yan , Yao Yao , Zhang Jinping
Published: September 2024

Objective: The aim of this study was to compare the efficacy and safety of anti-tau protein monoclonal antibodies for Alzheimer's disease (AD). By investigating the effects of monoclonal antibodies on cognitive function, disease progression, and overall quality of life in patients with AD, which can provide valuable insights into their potential as a therapeutic option for this devastating neurodegenerative disorder.
Methods: The randomized controlled trials (RCTs) of Gosuranemab, Semorinemab, Tilavonemab and Zagotenemab in the treatment of AD were searched in database of PubMed, Embase, Web of Science and Cochrane Library, up to May 2024. The control group included placebo. The efficacy indicators were change in the Mini Mental State Examination (MMSE), Clinical Dementia Rating Scale Sum of Boxes (CDR-SB), Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog), Alzheimer's Disease Cooperative Study-Activities of Daily Living Scale (ADCS-ADL) from baseline until the time of efficacy observation. The statistical analysis was performed by Stata14 and RevMan5.4. Data processing, network evidence plots, surface under the cumulative ranking curve (SUCRA) ranking, league plots and funnel plots were generated. Mean differences (MD) and 95% confidence interval (95%CI) as effect sizes to analyze continuous variables.
Results: This study included six RCTs with 2193 patients. Semorinemab were more effective than placebo in MMSE and ADAS-Cog scores (MDs ranging between 0.52 and 3.21; MDs ranging between 0.17 and 3.30). Placebo showed relatively good efficacy according to SUCRA ranking on change in CDR-SB and ADCS-ADL scores(75.7% and 79.5%). Tilavonemab and Semorinemab exhibited efficacy similar to that of a placebo in the analysis of the two indicators. Tilavonemab showed a lower incidence of AE, SAE, fall, and urinary tract infections than placebo, and the differences were statistically significant. Most safety analysis results showed no statistical difference.
Conclusions: Based on the results of this study, Semorinemab and Tilavonemab were recommended treatment options with relatively good efficacy and safety. These encouraging outcomes suggest that anti-tau protein monoclonal antibodies hold considerable potential as a viable therapeutic option for managing AD. Further exploration and clinical validation are warranted to fully elucidate the long-term effects and optimize treatment protocols in this evolving therapeutic landscape.
Transformation of hazardous residues from medical laboratory waste treatment plant into permeable brick
Authors: Wu Hsing-Hsien , Cheng Li-Chun , Huang Kuo-Lin , Huang Shih-Wei , Kuo Yi-Ming
Published: September 2024

In this study, the transformation of hazardous residues (fly ash, silica gel, bottom ash, and sludge) from a medical laboratory waste incineration system of Sustainable Environment Research Center into permeable bricks was investigated. The fly ash was elutriated using water twice to remove the Cl−. The elutriated fly ash was mixed with silica gel, bottom ash, and sludge with different formulas which were designed using response surface methodology (RSM) in Design Expert 8.0.6 software. The mixed materials were melted at 1450 ℃. The RSM analysis results showed that the most optimal effect was achieved when silica gel constituted 60% of the total sample and the elutriated fly ash constituted 10% of the encapsulated phase (elutriated fly ash, bottom ash, and sludge), in terms of minimizing the amount of unmelted materials and maximizing the percentage of mass reduction. The slag with optimal melting effect was mixed with cullet, clay, cement, and water, molded, cured, and transformed into permeable bricks. The physical properties met the regulations for grade-A bricks, and the Toxicity Characteristic Leaching Procedure (TCLP) results showed that metals were well encapsulated in the permeable bricks. Overall, the permeable bricks will offer sufficient physical strength and will not contribute to environmental pollution when recycled.
Effect of the oxidative phosphorylation signaling pathway related gene CPT1A on pyroptosis after sevoflurane anesthesia
Authors: Han Baoyi , Zhang Yue , Hu Zurong , Zhou Chuanhua , Yang Jingru , Jia Jie , Li Kunwei , Zhang Liangcheng
Published: September 2024

Background
Oxidative phosphorylation signaling pathway plays an important role after anesthesia. However, the link between oxidative phosphorylation related genes (OPRGs) and anesthesia is unclear.
Methods
Transcriptome data was downloaded from the Gene Expression Omnibus (GEO) databases, and 200 OPRGs were obtained from the Molecular Signatures Database (MSigDB). We systematically analyzed the expression profile characteristics of 200 OPRGs and confirmed data quality through tSNE and PCA analysis. Subsequently, the expression level and effect of OPRG carnitine O-palmitoyltransferase 1 (CPT1A) was validated by detected the expression level of inflammation factors. Finally, the activity of pyroptosis pathway was verified after overexpression or knockdown of CPT1A.
Results
We identified that the expression level of OPRGs were significantly regulated after sevoflurane anesthesia. Compared to the control group, the expression of the inflammatory factors IL-1β, IL-6, and TNF-α were increased. Then, the expression level of CPT1A was up-regulated after sevoflurane anesthesia. In addition, the pyroptosis pathway was activated through after upregulating the expression of inflammatory factors.
Conclusion
These findings highlight the effect of OPRG CPT1A during anesthesia, deepen the understanding of OPRGs, inflammation, and pyroptosis for patients in clinic anesthesia.
Advanced selective adsorption of alizarin dye from wastewater using novel nano-magnetic molecularly imprinted polymers
Authors: Rao Qingqing , Zhang Yunlong , Wang Ruru , Li Yuanlian , Yang Shuman , Wu Xinyi , Tong Fei , Kuang Yi , Yuan Bingnan N. , Yang Shengxiang
Published: September 2024

Dye wastewater exhibits a pronounced negative effect on the aquatic environment. However, the selective and efficient adsorption of dye from wastewater presents substantial challenges. Here, a novel surface molecularly imprinted polymer (Alizarin/SMIPs) was developed via an etched nanomagnetic carrier and computer-aided material design. The findings demonstrate that Alizarin/SMIPs exhibit high adsorption efficiency (60.94 mg·g‑1), excellent regeneration (≥ 11 cycles), and excellent magnetic responsive collection (6 s). In addition, the adsorption efficiencies of Alizarin/SMIPs for analogues were significantly lower at 20.26%. Inversely, the recovery rate of Alizarin/SMIPs for Alizarin in wastewater samples can reach 100%. Compared to previous studies, Alizarin/SMIPs demonstrate a high adsorption capacity, selectivity, recovery, and renewability for dye molecules. Besides, the results of the density functional theory (DFT) elucidated the potential interaction forces and binding sites between dye molecules and adsorbents, offering a promising adsorbent for efficient and targeted removal of dye molecules from dyestuff wastewater.