bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental investigation and numerical simulation of accelerating an aluminium sample for magnetic pulse welding
Authors: Anisimov A.G. , Ahmed Soliman M.E.
Published: April 2022

The induction acceleration method is quite widely used in impact experiments with conductive disks. The paper presents an experimental study and numerical simulation concerning magnetic pulse acceleration of thin flat discs made of D16AM aluminium alloy. We used a flat copper coil and a capacitor power source to investigate magnetic pulse welding possibilities. The high-energy pulse method is efficient, safe, capable of precisely setting pulse discharge power by varying the capacitor (energy storage) capacitance and voltage, while heating the work piece with induced current can lead to an increase in its plasticity. We used the LS-DYNA finite element analysis software package to run our numerical simulation. The results obtained show that there is a significant disadvantage to using this acceleration setup: it is difficult to ensure that the sample accelerated remains planar.
Perform Strikes. A Case Study
Authors: Malo Enrico Mora
Published: April 2022

In this paper we show the results of an analysis of the production of individual class subjectivities in the context of strikes among both those in favour and those against. Among the several processes going on in the production of subjectivities of class, we consider strikes because we want to emphasise the active role that the subjects keep up within the class relationships of domination and exploitation. We start from a conception of the subjectivity understood as fragmentary and contingent that we apply to our analysis of class, but in this paper we limit production of individual subjectivities to context of strikes. Our analysis focuses on a case study from the beginning of the 1970s to the end of the 1990s, which was led by the workers of a company in the motor industry, situated in Catalonia. The main devices used to work on the empirical material are biographical interviews and informative interviews. We start the analysis by showing the various directions taken by that the subjectivities of workers and of the company in strike interactions, in individual terms. Then we look into the role of gender in the provisional configuration of these subjectivities in the context of a strike when these subjectivities became collective subjectivities. In this respect, we focus on the company’s workers.
Mobilizing Voices: A Discussion of Leadership in an Environmentally Contaminated Community
Authors: Robinson Erin E.
Published: April 2022

Leadership is a key factor in successful social movement mobilization. Without a grasp of leadership dynamics in a community, it is difficult to explain how individuals come to occupy leadership roles and what impact this has on the overall success of a movement effort. In this study, I use the qualitative approach to investigate how leadership is framed in a community facing the existence of environmental contamination. I follow the development of leadership among actors and particularly the relationships that they create and maintain with expert environmental activists. Using interview data from 35 community residents and activists, I establish how leadership frames were presented to the community and how these frames impacted mobilization efforts and outcomes.
The Politics of Authenticity in a National Heritage Site in Israel
Authors: Noy Chaim
Published: April 2022

This paper offers a multifaceted appreciation of the political roles played by authenticity in modern tourism. The study, located at a national heritage and commemoration site in Jerusalem, Israel, traces authentic occurrences—manifestations and representations—that culminate in an ideological ecology of authenticity. Through this depiction, the active and often veiled role authenticity, understood as a social structure, plays is foregrounded. A special place within this ecology is reserved for the role performed by the site’s visitor book. The paper conceptualizes the commemorative visitor book as an ideological and institutional interface, which serves as an authenticating device. This device allows a transformation of visitors unto ideological social agents who partake in the structure of national commemoration in Israel.
PENGARUH MODEL PEMBELAJARAN PROBLEM BASED LEARNING DISERTAI PHET SIMULATION TERHADAP KETERAMPILAN PROSES SAINS DAN KEMAMPUAN PEMECAHAN MASALAH FISIKA DI SMA POKOK BAHASAN SUHU DAN KALOR
Authors: Lestari Sri Ayu , Supriadi Bambang , Harijanto Alex
Published: April 2022

The aims of this research were to investigate : (1) the influence of PBL model with PhET simulation to student’s science process skill’s; (2) the influence of PBL model with PhET simulation to student’s problem solving skill’s. this research used experimental research method. The sample of this student’s of slass XI IPA at MA Negeri 2 Jember. The data were collected by observation, documentation, and interview. The data was analyzed using the Independent sample t-test toshow the different between experiment class and control class. The results of the research were as follows: (1) PBL model with PhET simulation influence on science process skill’s of student’s (2) PBL model with PhET simulation influence on problem solving skill’s of student’s.

                                                                                                                                 

Keywords: Problem Based Learning, science process sklill, problem solving skill.
Participatory Geographic Information Systems (GIS): A Critical Methodological Approach for Urban Social Work Research
Authors: Roybal Kristi
Published: April 2022

This paper explores the utility of participatory GIS as a methodological approach for urban social work research focused on socioeconomically disadvantaged neighborhoods and resident health and well-being. The discussion begins with a brief overview of social work’s person-in-environment framework and the historical use of mapping in social work research and practice. Participatory GIS is then outlined and evaluated in the context of social work values and critical social work scholarship. Finally, consideration is given to the steps social work researchers can take to develop GIS skills and integrate participatory GIS into their community-based scholarship.
As condições ambientais do edifício Vilanova Artigas, sede da FAUUSP em São Paulo
Authors: Gonçalves Joana Carla Soares , Mülfarth Roberta Consentino Kronka , Michalski Ranny Loureiro Xavier Nascimento , Shimomura Alessandra Rodrigues Prata , Roméro Marcelo de Andrade , Furuyama Cristiane Mitiko Sato , Pinho Johnny Klemke Costa , Lima Eduardo Gasparelo , Carunchio Claudia Ferrara , Segovia Sylvia Tavares , Santos Karen Daiane dos
Published: April 2022

O edifício da Faculdade de Arquitetura e Urbanismo da Universidade de São Paulo (FAUUSP), na cidade de São Paulo, inaugurado em 1969 e tombado em 1982, é um marco da Escola Paulista de Arquitetura Moderna, expressando uma síntese entre estrutura, espaço e ambiente. A área de 40% de cobertura translúcida levanta questionamentos sobre o impacto da radiação solar incidente, durante o período mais quente do ano, nas condições luminosas e térmicas do interior. São apresentados neste artigo estudos de investigação técnica sobre as questões térmicas e de iluminação natural, com foco nos espaços dos estúdios e salas de aula, examinando os efeitos promovidos pela reforma da cobertura de 2014, que promoveu a troca dos domos. As análises de desempenho incluíram estudos analíticos realizados para o projeto da reforma. Dentre os resultados, viu-se que os ofuscamentos inerentes ao projeto original foram eliminados com o novo fechamento em acrílico leitoso, criando um ambiente luminoso homogêneo, sob a grande cobertura. Já as condições térmicas foram amenizadas com a redução de temperaturas internas máximas em 4 oC em um dia quente, devido ao aumento da ventilação alcançado com o levantamento das claraboias, porém o desconforto não foi eliminado, uma vez que as temperaturas máximas atingem por volta de 30 °C nos períodos mais quentes do ano.
HBIM e mapa de danos
Authors: Silva Felipe Bruno Lima da , Cuperschmid Ana Regina Mizrahy
Published: April 2022

Um dos mais importantes documentos para a avaliação do estado de conservação do patrimônio cultural construído é o Mapa de Danos, cuja função é apresentar de forma sintética e precisa as informações referentes às anomalias identificadas nessas construções, assim como suas ações corretivas. No entanto, esse documento é usualmente produzido em sistemas de representação bidimensional, que não favorecem uma estruturação consistente dessas informações, tampouco a interoperabilidade. A Modelagem da Informação da Construção Histórica (HBIM) oferece novas possibilidades para o registro dos danos, uma vez que toda a documentação poderia ser associada a um banco de dados e atualizada ao longo do ciclo de vida das construções históricas. Portanto, essa pesquisa tem como objetivo principal apresentar os resultados qualitativos de uma Revisão Sistemática da Literatura (RSL), desenvolvida com a finalidade de identificar o estado-da-arte de pesquisas relevantes que correlacionam os conceitos de HBIM e Documentação de Danos do Patrimônio Construído. A pesquisa foi realizada em seis etapas: (1) Definição da Questão; (2) Estratégia de Busca; (3) Triagem e Elegibilidade; (4) Avaliação da Qualidade; (5) Síntese dos Resultados e (6) Apresentação do Estudo. Foram constatadas distintas finalidades para a documentação diagnóstica utilizando a metodologia HBIM, como avaliação estrutural e gestão de obras de restauro e conservação. Entretanto, foram ressaltadas dificuldades de interoperabilidade entre as ferramentas, que precisam ser aprimoradas de forma a possibilitar a comunicação e gestão das informações relacionadas ao Patrimônio Cultural Construído.
Reflexões e perspectivas do “conhecimento pertinente” de Edgard Morin no âmbito da cidade saudável
Authors: Bloes Rodrigo Brandini , Sperandio Ana Maria Girotti
Published: April 2022

O pensamento iluminista submete as inteligências humanas à senda da racionalidade, institucionaliza e consolida a setorização e distancia as ideias de trabalho, habitação e lazer no ambiente urbano. O aumento da expectativa e qualidade de vida no último século não representa um campo resoluto, mas é acompanhado pela crise do capitalismo, do espaço urbano e do próprio planejamento.  Como proposta para promover a qualidade de vida, no final do século XX, foi desenvolvido o conceito de cidades saudáveis. O Pensamento Complexo de Edgard Morin pode contribuir para a superação das limitações atuais do planejamento urbano no âmbito da concepção. Este artigo tem o objetivo de trazer reflexões referentes às contribuições de um dos Sete Saberes de Edgard Morin, o “Conhecimento Pertinente” e a proposta de Cidades Saudáveis para um novo posicionamento do planejamento urbano, sob a perspectiva da problemática do ambiente urbano no século XXI. Por meio do materialismo histórico e da revisão de literatura foi possível explorar as aproximações conceituais e refletir sobre suas similitudes. A partir da reflexão realizada foi possível apontar contribuições que os dois campos estudados apresentam para superar as crises da ordem do planejamento urbano, assim como para a formação de uma nova percepção de mundo, por meio da transformação do próprio indivíduo e das relações entre o local e o global.
Pewarnaan Titik Ketakteraturan Lokal Inklusif pada Hasil Operasi Comb Graf Bintang
Authors: Kristiana Arika Indah , Indriani Surya , Albirri E.R
Published: April 2022

Let G(V,E) is a simple graph and connected where V(G) is vertex set and E(G) is edge set. An inclusive local irregularity vertex coloring is defined by a mapping l:V(G) à {1,2,…, k} as vertex labeling and wi : V(G) à N is function of inclusive local irregularity vertex coloring, with wi(v) = l(v) + ∑u∈N(v) l(u). In other words, an inclusive local irregularity vertex coloring is to assign a color to the graph with the resulting weight value by adding up the labels of the vertices that are neighbouring to its own label. The minimum number of colors produced from inclusive local irregularity vertex coloring of graph G is called inclusive chromatic number local irregularity, denoted by Xlisi(G). In this paper, we learn about the inclusive local irregularity vertex coloring and determine the chromatic number of comb product on star graph.
Analisis Kestabilan Model Matematika Predator-Prey pada Dinamika Sosial
Authors: Gepak Laurensia Regina Bestari , Miswanto Miswanto , Alfiniyah Cicik
Published: April 2022

In social life, difference and diversity is something that cannot be denied by anyone. Starting from differences horizontally concerning ethnicity, language, customs to religion and vertically concerning the political, social, cultural to economic fields. The existence of these many differences can certainly bring positive and negative impacts in social life. With diversity, interaction in society is dynamic, but it results in the emergence of negative attitudes such as egoism and competition between groups. From the occurrence of this can trigger the problem of social inequality in the community. Social inequality can occur because of national development efforts that only focus on economic aspects and forget about social aspects. The purpose of this thesis is to discuss the stability analysis of the predator-prey mathematical model on social dynamics with the Holling type II functional response. From this model analysis, we obtained four equilibrium points, which are the equilibrium point for the extinction of all population (E0) which is unstable, then the equilibrium point for the extinction of the non-poor population and the poor (E1) and the extinction of the non-poor population (E2) which are stable with certain conditions and coexistence (E3) which is to be asymptotically stable. Also in the final section, we perform the numerical simulation to supports the analytical result.
The Digital Marketing Model Uses Social Media to Get Out Of The Economic Crisis Caused By Covid 19
Authors: Putra Saiful Aminudin Al Kusuma , Sucipto Beni , Rachmadana Satria Lintang
Published: April 2022

The phenomenon of covid-19 has not been completed because the virus continues to mutate from the alpha, delta, gamma to Omicron variants, this variant is more virulent and quickly spreads than the previous variant. The impact is still being felt today. This study aims to investigate how SMEs can deal with crises and the strategies they have used to maintain their business, to prepare SMEs for future crises. The population in this study are SMEs who are members of the Institute for Modern Creative Industries (LIKM). The sampling technique used purposive sampling technique with 6 sources. This research is a type of qualitative research with a case study approach. The type of case study used is a collective or multiple case study. This study uses primary data. Data collection techniques used in this study were interviews and observation. The data analysis technique used is the spiral model technique. The results of this study, so that SMEs can survive the strategy used is to increase advertising and promotion through social media. Marketing using social media clearly has a very high effectiveness and contributes to sales volume. The marketing model found shows that the higher the understanding of business actors on the potential of digital marketing using social media, the more precise they will be in choosing a marketing model using social media
PENGARUH MODEL PEMBELAJARAN MEANS ENDS ANALYSIS TERHADAP KEMAMPUAN BERPIKIR TINGKAT TINGGI SISWA KELAS VII
Authors: Muliyati Muliyati , Ansori Hidayah , Suryaningsih Yuni
Published: April 2022

Siswa pada saat sekarang ini sudah seharusnya memiliki kemampuan berpikir tingkat tinggi. Akan tetapi kemampuan berpikir tingkat tinggi siswa masih kurang hal ini dikarenakan masih banyak siswa kurang menguasai konsep dasar materi yang diajarkan guru, dan masih kurangnya kesadaran siswa untuk belajar matematika. Model pembelajaran berbasis pemecahan masalah diperlukan agar kemampuan berpikir tingkat tinggi siswa dapat berkembang. Salah satu model pembelajaran berbasis masalah adalah Means Ends Analysis (MEA). Penelitian ini bertujuan (1) mengetahui kemampuan berpikir tingkat tinggi siswa kelas VII SMP Negeri 13 Banjarmasin yang pembelajarannya mengaplikasikan model pembelajaran MEA, (2) mengetahui kemampuan siswa kelas VII SMP Negeri 13 Banjarmasin yang pembelajarannya mengaplikasikan pembelajaran konvensional dalam berpikir tingkat tinggi, dan (3) mengetahui pengaruh model pembelajaran MEA terhadap kemampuan berpikir tingkat tinggi siswa kelas VII SMP Negeri 13 Banjarmasin. Penelitian ini menggunakan metode eksperimen semu dengan desain nonequivalent posttest-only control .Populasi pada penelitian ini yaitu siswa kelas VII SMP Negeri 13 Banjarmasin dengan sampel yang diambil dengan teknik purposive random sampling. Data dikumpulkan dengan teknik dokumentasi serta tes. Hasil penelitian memperlihatkan bahwa (1) siswa yang belajar dengan mengaplikasikan model pembelajaran MEA kemampuan berpikir tingkat tingginya berada pada kualifikasi cukup, (2) siswa yang belajar dengan mengaplikasikan model pembelajaran konvensional kemampuan berpikir tingkat tingginya berada pada kualifikasi kurang, dan (3) model pembelajaran Means Ends Analysis (MEA) berpengaruh pada kemampuan berpikir tingkat tinggi siswa.
PENGEMBANGAN LKPD DENGAN LIVEWORSHEET BERBASIS DISCOVERY LEARNING MATERI TRANSFORMASI UNTUK SEKOLAH MENENGAH PERTAMA
Authors: Rifky Ahmad , Karim Karim , Sari Asdini
Published: April 2022

Alternatif penggunaan perangkat pembelajaran berbasis teknologi untuk pembelajaran daring salah satunya adalah LKPD online dengan liveworksheet. LKPD online ini dikembangkan dengan tujuan agar lebih memudahkan dalam proses pembelajaran daring. Berdasarkan Praktek Pengajaran di Sekolah dan hasil wawancara diperoleh masalah mengenai kesulitan peserta didik dalam memahami konsep transformasi sehingga dengan pengembangan LKPD ini diharapkan dapat mengurangi masalah tersebut. Produk yang dikembangkan adalah LKPD dengan liveworksheet berbasis discovery learning dimana peserta didik yang lebih aktif untuk mengkonstruksi atau menemukan konsep matematika untuk dirinya sendiri. Hal ini dapat membuat pemahaman yang mereka dapatkan akan lebih mendalam. Tujuan penelitian ini yaitu menghasilkan LKPD dengan liveworksheet yang valid. Penelitian ini menggunakan model pengembangan ADDIE (analysis, design, development, implementation, evaluation) namun dengan sedikit modifikasi yaitu penelitian terbatas tahap development saja. Hasil uji kelayakan materi pada LKPD yang dikembangkan yaitu 83,97% memenuhi kriteria cukup valid dan hasil uji kelayakan media yang dikembangkan yaitu 81,67% memenuhi kriteria cukup valid. Dapat diambil kesimpulan bahwa pengembangan LKPD dengan liveworksheet berbasis discovery learning pada Materi Transformasi untuk Sekolah Menengah Pertama merupakan LKPD yang valid.
PENGEMBANGAN VIDEO PENDUKUNG PEMBELAJARAN PADA MATERI MATRIKS UNTUK KELAS XI SMA BERBANTUAN MEDIA SOSIAL “TIKTOK”
Authors: Amelia Rizka , Zulkarnain Iskandar , Hidayanto Taufiq
Published: April 2022

Media pembelajaran berupa video sudah banyak digunakan dalam pembelajaran karena mempermudah siswa dalam belajar. Namun, tidak semua video disukai oleh siswa terutama jika video yang disajikan memiliki durasi yang sangat panjang dan sulit diakses. Hal tersebut dapat mengakibatkan hilangnya motivasi belajar siswa. Untuk menyiasati hal tersebut adalah dengan memanfaatkan media sosial seperti aplikasi TikTok yang kini sedang tren di kalangan anak muda. Dengan konsep video berdurasi pendek dan daya tarik dari platform tersebut diharapkan dapat meningkatkan motivasi siswa dalam belajar. Penelitian ini memiliki tujuan untuk mendeskripsikan proses dan menghasilkan video pendukung pembelajaran pada materi matriks untuk kelas XI SMA berbantu media sosial TikTok yang valid. Penelitian ini dilakukan melalui metode Research and Development memakai model 4D yang dikembangkan oleh Thiagarajan, Semmel & Semmel, namun pada penelitian ini hanya melakukan tiga tahapan yaitu define, design, dan develop. Pengumpulan data dilakukan menggunakan lembar validasi. Ada tiga orang ahli yang melakukan validasi, yaitu dua dosen prodi pendidikan matematika dan satu orang guru matematika SMA. Berdasarkan penilaian yang diberikan oleh tiga orang validator didapatkan skor rata-rata sebesar 83,04% dengan kriteria cukup valid. Dengan demikian, kriteria kevalidan video pendukung pembelajaran pada materi matriks untuk kelas XI SMA berbantu media sosial TikTok telah tercapai.
Assessment of bunch thinning as a management technique for Semillon and Shiraz in a hot Australian climate
Authors: De Bei Roberta , Wang Xiaoyi , Papagiannis Lukas , Collins Cassandra
Published: April 2022

Bunch thinning is a widespread management practice in vineyards and it has been reported to improve grape and wine quality depending on the timing and intensity of its application. This study assessed whether bunch thinning could affect vine performance, grape and wine chemistry and sensory attributes for Shiraz and Semillon in a hot Australian climate.Own rooted Semillon and Shiraz vines planted in 1990 at the Waite Campus of the University of Adelaide were evaluated. For both varieties, bunch thinning was carried out by removing 50 % of bunches at veraison (EL35) for four and two seasons for Semillon and Shiraz, respectively. Vine performance, berry and wine chemistry and berry and wine sensory characteristics were assessed. Results showed a dramatic effect on yield but only minor effects on the other yield components. Berry and wine chemistry were also mostly unaffected by the treatment. Semillon wines from un-thinned vines were preferred, while for Shiraz, bunch thinning improved the wine acceptance by the sensory panel.To support the decision on whether to bunch thin and justify its cost, a significant increase in fruit and wine quality should be expected; however, in this study, only mild effects were found. This study provides the wine industry with a better understanding of the effects of bunch thinning in a hot climate.
Ethanol sclerotherapy and laparoscopic cystectomy for ovarian endometriomas. Comparative analysis of efficacy and reproductive outcomes
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Davydov A.I. , Ishchenko A.I. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Unanyan A.L. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Pivazyan L.G. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Azarenkov G.V. ,   Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation, Zakaryan A.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Denisova A.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Tairova M.B. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: April 2022

Objective. To study and systematize the results of ethanol sclerotherapy in patients with ovarian endometriomas and perform a comparative analysis of the efficacy of sclerotherapy and cystectomy according to international research publications. Materials and methods. Electronic searching was conducted through Medline, PubMed, Google Scholar, ClinicalTrials, and Cochrane Library databases for cohort studies and randomized controlled trials only. A systematic review was performed using preferred reporting items for systematic reviews and meta-analyses (PRISMA). A total of 626 articles were reviewed. The Cochrane Collaboration’s tool was used to assess the quality of the studies. Results. It was shown that ethanol sclerotherapy for ovarian endometriomas bears the lowest risk in terms of surgical complications; it is highly economical in combination with maximum fertility preservation, which is especially relevant in assisted reproductive technology programs. The effectiveness of this method is largely determined by the conditions for its use, as well as by the time of ethanol exposure (optimally not less than 7 minutes). At the same time, ethanol puncture of endometrial cysts is not a monotherapy, and its outcome is greatly influenced by the adequacy of postoperative hormonal treatment. The use of 30 μg ethinylestradiol + 2 mg dienogest was shown to be promising. Conclusion. Ethanol sclerotherapy for ovarian endometriomas should be performed in accordance with the developed conditions and indications for its use in combination with postoperative hormonal treatment. Key words: endometriosis, ovarian endometrioma, sclerotherapy, cystectomy, ethinylestradiol + dienogest
Premature rupture of membranes in full-term pregnancy: controversial issues in obstetric management
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Ignatko I.V. , Churganova A.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Rodionova A.M. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Baybulatova Sh.Sh. ,   City Clinical Hospital No 4, Grozny, Russian Federation, Silaeva T.M. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Megrabyan A.D. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Denisova Yu.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: April 2022

Premature rupture of membranes is a complication of pregnancy, which is developed in full-term in 8% of cases. Spontaneous labor usually occurs within the next 24 hours, but the latency period may be longer. A prolonged anhydrous period is associated with a significantly increased risk of infection and adverse perinatal outcomes, including early-onset neonatal sepsis, with mortality rates approaching 50% in the absence of treatment. The problem of choosing pregnancy management strategy is highly controversial: conservative treatment increases the risk of chorioamnionitis and endometritis, while invasive approach may lead to complications associated with surgical intervention and fetal dysmaturity. The maximum duration of the latency period after which to proceed to labor induction is under discussion. The article analyzes the current data on the advantages and disadvantages of each strategy, evaluates the possibility of outpatient management of low-risk pregnant women using conservative treatment, the need for antibiotic prophylaxis, and the effectiveness of uterotonics. The data were searched in the PubMed digital library, Clinical Trials database, and Cochrane Database of Systematic Reviews. A review of the literature showed that active conservative treatment followed by the induction of labor with oxytocin is the most appropriate, with the final choice of management to be left to the pregnant woman in case of low-risk obstetric and perinatal complications. Key words: premature rupture of membranes, full-term pregnancy, labor induction, chorioamnionitis, antibiotic prophylaxis, mifepristone
Assisted reproductive technologies and children’s health: long-term outcomes
Authors:   Tyumen State Medical University, Tyumen, Russian Federation, Malinina E.I. , Mokshina D.V. ,   Tyumen State Medical University, Tyumen, Russian Federation, Mazitov A.D. ,   Tyumen State Medical University, Tyumen, Russian Federation, Rychkova O.A. ,   Tyumen State Medical University, Tyumen, Russian Federation, Khvoshchina T.N. ,   Tyumen State Medical University, Tyumen, Russian Federation
Published: April 2022

The biological fertility potential in mothers of late reproductive age is limited by the natural decline in fertility and infertility. Despite the significant success and the introduction of new diagnostic and therapeutic reproductive technologies into clinical practice, the problem of childlessness is far from being finally resolved. The health status of children born after the use of assisted reproductive technologies is another open issue. The up-to-date data on the adverse effects of in vitro fertilization (IVF) do not have adequate substantiation, since the external parental factors cannot be reliably excluded: age, concomitant metabolic, genetic and epigenetic changes. Negative results regarding the state of the nervous and endocrine systems, congenital malformations, and cancer predisposition are inconsistent and refuted by other major population studies. The analysis of genetic and epigenetic disorders is difficult because of their rare incidence. For each parameter of children’s health, there is an objective need to assess and differentiate the influence of parental factors and factors directly related to the IVF procedure. Key words: assisted reproductive technologies, in vitro fertilization, malformations, children's health, oncologist, neurologist
Sleep-related breathing disorders and BPD-associated pulmonary hypertension in preterm infants
Authors:   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Trapeznikova A.Yu. , Petrova N.A. ,   Almazov National Medical Research Centre, Saint Petersburg, Russian Federation, Obraztsova G.I. ,   Almazov National Medical Research Centre, Saint Petersburg, Russian Federation, Sviryaev Yu.V. ,   Almazov National Medical Research Centre, Saint Petersburg, Russian Federation,   Sechenov Institute of Evolutionary Physiology and Biochemistry, Saint Petersburg, Russian Federation, Boytsova E.V. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Ivanov D.O. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation
Published: April 2022

This article presents current data on the features of sleep-related breathing disorders in preterm infants with bronchopulmonary dysplasia (BPD) and pulmonary hypertension. The data on BPD-associated pulmonary hypertension, morphological changes in lung tissue, possible complications and clinical outcomes in this pathology were summarized. The basic data on intermittent hypoxic episodes, apnea and periodic breathing and their influence on the development and maintenance of pulmonary hypertension were reviewed. The methods were described that allow to accurately differentiate the character of sleep-related breathing disorders for the purpose of timely diagnosis and correction of therapy. The feasibility of using polysomnography and cardiorespiratory sleep monitoring as diagnostic methods for this category of patients was substantiated. Key words: BPD-associated pulmonary hypertension, breathing disorder, preterm infants
Potential of ultrasound elastography and three-dimensional echocardiography in the diagnosis of tubal pregnancy
Authors:   “Zdravia Medical Clinic” LLC, Moscow, Russian Federation, Shishkina T.Yu. , Aksenova V.B. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: April 2022

A clinical case describing the potential of elastography and three-dimensional echocardiography in tubal pregnancy in a patient who was not initially diagnosed during laparoscopy is presented. The dynamic observation showed an increase in serum chorionic gonadotropin; the postoperative follow-up with elastography and three-dimensional echocardiography revealed signs of initially progressive and subsequently interrupted tubal pregnancy (the patient refused a second laparoscopy). Threedimensional echocardiography contributed to better visualization of the ovum compared to the B-mode image; the sign of tubal pregnancy (a vascular “ring of fire”) was clearly identified in the glass-body mode. A laparoscopic tubal ligation was then performed. The diagnosis was confirmed histologically. Conclusion. Ultrasound elastography and three-dimensional echocardiography contribute to better diagnosis of tubal pregnancy in complicated clinical situations. Key words: tubal pregnancy, ectopic pregnancy, elastography, three-dimensional echocardiography, vascular “ring of fire”
Experience with recombinant activated coagulation factor VII in the treatment of massive obstetric hemorrhage
Authors:   Academician V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russian Federation, Fedorova T.A. , Barkovskaya N.A. ,   Privolzhsky Research Medical University, Nizhny Novgorod, Russian Federation,   Dzerzhinsk Perinatal Center, Dzerzhinsk, Russian Federation, Vdovin V.A. ,   Kazan State Medical University, Kazan, Russian Federation,   City Clinical Hospital No 7, Kazan, Russian Federation, Rogachevsky O.V. ,   Academician V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russian Federation, Katkova N.Yu. ,   Privolzhsky Research Medical University, Nizhny Novgorod, Russian Federation, Davydova V.R. ,   Kazan State Medical University, Kazan, Russian Federation
Published: April 2022

This article presents the results of a retrospective observational study on the use of recombinant activated coagulation factor VII (Eptacog alfa [activated], Coagil-VII) to evaluate its efficacy and safety in the treatment of massive obstetric hemorrhage (MOH) in 30 women with volume of circulating blood loss over 25%; 90% of women delivered by cesarean section, and 10% of women delivered by vaginal birth. The efficacy and safety of Coagil-VII as a hemostatic agent in intensive therapy for MOH were evaluated using clinical, laboratory and statistical research methods. The administration of Eptacog alfa [activated] (Coagil-VII) helped to significantly reduce the volume of blood loss, duration, time and rate of bleeding, and the amount of blood component transfusion. The total dose of the drug was 3.68 mg. The analysis of laboratory parameters (hemogram, blood biochemistry tests) in patients of the study group with MOH did not reveal any negative effect of Coagil-VII according to the parameters. The results of the hemostatic system assessment showed that after administration of Coagil-VII there was an increase in blood coagulation potential, as evidenced by a decrease in International Normalized Ratio, shortened prothrombin and thrombin time, activated partial thromboplastin time. All parameters were within the reference range, without increasing the risk of thrombotic complications. No thrombotic complications in the early and late postoperative/postpartum period were detected in any patient. Hysterectomy in this study group was performed in 7 (23.3%) patients; the uterus was preserved in 23 (76.7%) women with MOH. The use of modern hemostatic drug Coagil-VII in the complex treatment of MOH under the control of clinical laboratory testing helped to stop (in 86.6% of women) or reduce the intensity of hemorrhage (in 13.3% of patients), reduce the amount of transfused blood components, improve the patients’ condition without thrombotic complications, reduce possible complications associated with transfusions and the cost of therapy, and implement organ preservation tactics in 76.7% of women. Key words: pregnancy, safety, massive hemorrhage, patient blood management, fertility, efficacy
Effect of fetal sex on the course of pregnancy and perinatal outcomes in preterm birth
Authors:   V.I.Razumovsky Saratov State Medical University, Saratov, Russian Federation, Khvorostukhina N.F. , Kolesnikova E.A. ,   V.I.Razumovsky Saratov State Medical University, Saratov, Russian Federation, Stepanova N.N. ,   V.I.Razumovsky Saratov State Medical University, Saratov, Russian Federation, Novichkov D.A. ,   V.I.Razumovsky Saratov State Medical University, Saratov, Russian Federation, Romanovskaya A.V. ,   V.I.Razumovsky Saratov State Medical University, Saratov, Russian Federation, Plekhanov A.A. ,   V.I.Razumovsky Saratov State Medical University, Saratov, Russian Federation
Published: April 2022

Objective. To study the effect of fetal sexual dimorphism on the course of pregnancy and perinatal outcomes in preterm birth (PB). Patients and methods. The inclusion criterion was singleton PB at 22–36.6 weeks’ gestation (n = 1411) between 2014 and 2016 with male births (group 1, n = 789) and female births (group 2, n = 622). When analyzing medical histories of PB, the aspects of obstetrical and gynecological history, comorbidities, complications of the present pregnancy, date and methods of delivery were considered. Perinatal outcomes were assessed in terms of perinatal morbidity and mortality rates. Statistical analysis was performed using Statistica 7.0 software package. Results. The incidence of PB in mothers of boys increases 1.3-fold, increasing the likelihood of very early and early PB. The course of pregnancy in group 1 was found to be more often associated with anemia and acute respiratory viral infections and with threatened miscarriage, premature rupture of membranes, polyhydramnios, and pre-eclampsia. Patients in group 2 had an increased incidence of vulvovaginitis, pyelonephritis, gestational hypertension, and fetal growth restriction. Premature boys are more likely to develop intrauterine hypoxia, asphyxia, and respiratory distress syndrome. Conclusion. The results of the study indicate that further research in this area is needed to improve the quality of care for pregnant women, taking into account the sex of the fetus. Key words: pregnancy, pregnancy complications, perinatal morbidity, fetal sex, preterm birth
Optimization of management strategies in pregnant women with portal hypertension of different genesis
Authors:   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Apresyan S.V. ,   A.K.Eramishantsev City Clinical Hospital, Moscow, Russian Federation, Kira E.F. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Shemanaeva T.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Manukyan G.V. ,   Academician B.V.Petrovsky Russian Scientific Centre of Surgery, Moscow, Russian Federation, Kitsenko E.A. ,   Academician B.V.Petrovsky Russian Scientific Centre of Surgery, Moscow, Russian Federation, Alazhazhi M. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation,   A.K.Eramishantsev City Clinical Hospital, Moscow, Russian Federation
Published: April 2022

Objective. To optimize the management strategies in pregnant women with portal hypertension (PH) of different genesis. Patients and methods. Forty-four women with PH aged 19 to 44 years were examined and divided into two groups depending on the pathogenesis of PH. Group I (n = 24) included women with extrahepatic PH, group II (n = 20) – women with hepatic PH. Esophagogastroduodenoscopy, ultrasound, doppler ultrasound, fetal cardiotocography, and clinical and biochemical laboratory examinations were used as research methods. Results. Thrombophilia, anemia of varying severity, and liver cirrhosis have an impact on the development of pre-eclampsia, threatened preterm labor, placental insufficiency, and low birth weight in newborns. PH during pregnancy is a risk factor for bleeding from esophageal varices. Careful monitoring of patients using instrumental methods and management of pregnancy by obstetrician-gynecologists and surgeons create conditions for favorable perinatal outcomes. Conclusion. The risk of bleeding from esophageal varices during pregnancy, regardless of gestational age, and in the postpartum period is significantly more common in patients in group I compared to group II; the method of prevention is anticoagulant therapy. Key words: pregnancy, placental insufficiency, portal hypertension, preterm birth, cirrhosis
Microbiological and biochemical patterns of amniotic fluid in full-term pregnancy complicated by premature rupture of membranes
Authors:   Samara State Medical University, Samara, Russian Federation, Kaganova M.A. , Spiridonova N.V. ,   Samara State Medical University, Samara, Russian Federation, Medvedchikova-Ardiya L.K. ,   V.D.Seredavin Samara Regional Clinical Hospital, Samara, Russian Federation, Mikhalchenko S.V. ,   Samara State Medical University, Samara, Russian Federation, Nesterenko S.A. ,   Samara State Medical University, Samara, Russian Federation, Katyushina V.O. ,   Samara State Medical University, Samara, Russian Federation
Published: April 2022

Objective. To study the connection between the microbial landscape and biochemical composition of amniotic fluid (AF) in fullterm pregnancy and premature rupture of membranes (PROM). Patients and methods. The biochemical (glucose, total protein, urea, creatinine, calcium, potassium, sodium, chlorine, C-reactive protein) and microbial compositions of AF at 37–41 weeks’ gestation were examined in 39 pregnant women who delivered by cesarean section. The main group included 20 patients with PROM (the latency period <6 h), the control group – 19 patients with intact amniotic membranes. The microbial composition was evaluated using a real-time polymerase chain reaction (Femoflor-16). Results. The total bacterial load was 103.02 GE/mL in the main group of patients with PROM and 103.06 GE/mL in the control group, with predominant Enterobacteriaceae spp. – 15 and 21%, respectively; facultative and obligate anaerobic bacteria were identified in rare cases. In the biochemical analysis of AF, the levels of total protein and C-reactive protein were higher in patients with PROM, whereas the levels of creatinine, calcium, and potassium were lower. A weak positive correlation between creatinine levels with the presence of Gardnerella vaginalis in AF (r = 0.399, p = 0.032), potassium levels with Enterobacteriaceae spp. (r = 0.378, p = 0.043), and sodium levels with Streptococcus spp. (r = 0.383, p = 0.040) was observed. Conclusion. The presence of Enterobacteriaceae spp. is typical for AF. According to biochemical parameters in PROM, there is an increase in the levels of total protein and a decrease in the levels of creatinine and ions. Key words: amniotic fluid, pregnancy, biochemical analysis, microbiota, premature rupture of membranes, polymerase chain reaction, femoflor
Efficacy of recombinant interferon α-2b in the complex therapy of COVID-19
Authors:   Privolzhsky Research Medical University, Nizhny Novgorod, Russian Federation, Krasnov V.V. , Katirkina A.A. ,   Infectious Clinical Hospital No 23, Nizhny Novgorod, Russian Federation, Zubarov P.G. ,   Infectious Clinical Hospital No 23, Nizhny Novgorod, Russian Federation, Levina A.A. ,   Infectious Clinical Hospital No 23, Nizhny Novgorod, Russian Federation, Bragina G.S. ,   N.F.Gamaleуа National Research Center for Epidemiology and Microbiology, Moscow, Russian Federation, Vyzhlova E.N. ,   N.F.Gamaleуа National Research Center for Epidemiology and Microbiology, Moscow, Russian Federation
Published: April 2022

Objective. To evaluate the efficacy and safety of VIFERON® (recombinant interferon α-2b) rectal suppositories and gel for external and local use in the complex therapy of COVID-19 in adult patients. Patients and methods. 140 patients with COVID-19 were included in a prospective comparative controlled research study. The main group consisted of 71 patients who received standard therapy for coronavirus infection in combination with VIFERON® (rectal suppositories 3.000.000 IU for 1 supp. 3 times a day and gel 36.000 IU/g 5 times a day on the surface of nasal mucosa and palatine tonsils for 14 days); the comparison group – 69 patients who received standard therapy. Results. Patients who received VIFERON® complex therapy demonstrated more rapid clinical improvement by reducing the duration of symptoms of weakness and intoxication compared to the patients who received only standard therapy. The high activity of VIFERON® in elimination rate of SARS-CoV-2 RNA in nasopharyngeal samples was shown. The use of VIFERON® made it possible to achieve a stable concentration of IL-6 in the blood serum during the entire follow-up period. There were no adverse events associated with the administration of VIFERON®. Conclusion. The results obtained indicate the superiority of therapy with the inclusion of VIFERON® over standard therapy. Given the favorable safety profile, the studied regimen can be recommended for the treatment of adult patients, especially from risk groups, where the possibilities of conventional etiotropic therapy are limited due to possible toxicological effects. Key words: VIFERON®, human recombinant interferon α-2b, COVID-19 coronavirus infection
Clinical and epidemiological significance of diarrhea in children with COVID-19
Authors:   Russian Medical Academy of Continuig Professional Education, Moscow, Russian Federation, Mazankovа L.N. , Gorbunov S.G. ,   Russian Medical Academy of Continuig Professional Education, Moscow, Russian Federation, Samitova E.R. ,   Russian Medical Academy of Continuig Professional Education, Moscow, Russian Federation,   Z.A.Bashlyayeva Children's City Clinical Hospital of the Moscow Healthcare Department, Moscow, Russian Federation, Osmanov I.M. ,   Z.A.Bashlyayeva Children's City Clinical Hospital of the Moscow Healthcare Department, Moscow, Russian Federation, Akimkin V.G. ,   Central Research Institute of Epidemiology of the Federal Service on Customers' Rights Protection and Human Well-being Surveillance, Moscow, Russian Federation, Ploskireva A.A. ,   Central Research Institute of Epidemiology of the Federal Service on Customers' Rights Protection and Human Well-being Surveillance, Moscow, Russian Federation, Os’kin А.N. ,   Russian Medical Academy of Continuig Professional Education, Moscow, Russian Federation, Mishkin A.A. ,   Central Research Institute of Epidemiology of the Federal Service on Customers' Rights Protection and Human Well-being Surveillance, Moscow, Russian Federation
Published: April 2022

Objective. To show the clinical and epidemiological significance of diarrhea and SARS-CoV-2 excretion in the feces of COVID-19 patients in children. Patients and methods. 42 case histories of children with COVID-19 hospitalized and examined by PCR for SARS-CoV-2 RNA in nasal and oropharyngeal swabs, as well as in feces were ana-lyzed. Design: retrospective analysis of patient medical records. Results. It was shown that watery diarrhea was observed in 2.4% of children with verified COVID-19, vomiting and abdominal pain – in 4.8%. In the blood test, lymphocytosis prevailed. In all the examined patients, SARS-CoV-2 RNA was detected not only in nasal and oropharyngeal swabs, but also in feces, while in 4.8% of children, the virus was excreted in feces for a longer time than in the respiratory tract. In the epidemiological history of 100% of patients, there was no indication of contact with a patient with acute diarrhea. Conclusion. These facts indicate that, despite the infrequently registered diarrhea in COVID-19 in childhood, the detection of SARS-CoV-2 RNA in the feces of a significant number of such patients may have important clinical and epidemiological significance, contributing to the fecaloral transmission of this infection, which requires additional study due to the small number and incon-sistency of currently known data. Key words: diarrhea, COVID-19, SARS-CoV-2, children