bluuebunny/crossref_metadata_2025 huggingface dataset:
Advanced Limited Search Strategy for Enhancing the Performance of MPPT Algorithms
Authors: Pervez Imran , Antoniadis Charalampos , Massoud Yehia
Published: August 2022

Photovoltaic (PV) arrays are gaining popularity for electricity generation due to their simple and green energy production. However, the power transfer efficiency of PV varies depending on the load’s electrical properties, the PV panels’ temperature, and the insolation conditions. Maximum Power Point Tracking (MPPT) is a method formulated as an optimization problem that adjusts the PV output voltage to deliver maximum power to the load based on these criteria (maximum power in the P-V curve). MPPT is a convex optimization problem when the Sun’s rays completely cover the PV surface (full insolation). Several power points are formed in the Power vs. Voltage (P-V) curve, rendering MPPT as a non-convex problem during incomplete insolation (partial shadowing) on the PV surface due to barriers such as passing clouds or trees in the path of the Sun and the PV’s surface. Unfortunately, mathematical programming techniques, such as gradient ascent and momentum, are not good optimization candidate algorithms because they cannot distinguish between the local and global maximum of a function (the case of non-convex problems). On the other hand, metaheuristic algorithms have better search space exploration capability, making it easier to discern the P-V curve’s local and global power peaks. However, due to their pseudorandom search space exploration (random with some intuition), there is plenty of room for improving their performance. In this work, we elaborate on the Advanced Limited Search Strategy (ALSS), a technique we proposed in one of our previous works on MPPT. We prove its universal usefulness by applying it to other MPPT algorithms to enhance their performance. The ALSS first finds the direction where it is most probable to discover the MPP using the finite difference between two candidate duty cycles and then computes a duty cycle between two bounds designated by the previous direction. After that, the resulting duty cycle is further updated according to the metaheuristic update equation. Therefore, the single solution update is another advantage of ALSS that further improves the computational cost of the MPPT algorithms.
Design and Validation of a SEPIC-Based Novel Multi-Input DC-DC Converter for Grid-Independent Hybrid Electric Vehicles
Authors: Bairabathina Saikumar , S Balamurugan
Published: August 2022

The multi-input converters play a significant role in developing grid-independent hybrid electric vehicles (GIHEVs). This article describes the design and analysis of a single-ended primary-inductor converter (SEPIC)-based novel multi-input DC-DC converter (MIC) for grid-independent hybrid electric vehicles (GIHEVs) that is powered by a solar photovoltaic (PV) panel and a fuel cell. The average large-signal, small-signal, and steady-state modelings are demonstrated to achieve high-quality design and analysis. The proposed converter promises wide output voltage and power flow management at lower duty cycle values. The sources can transfer energy to the load either jointly or individually in this converter with the appropriate operation of the power switches. A hardware prototype is also developed and tested efficiently to uphold the mathematical modeling, design, and operation. With fewer switches, lower voltage stress, and fewer circuit components, the suggested converter claims better gain and higher (96%) efficiency.
Modeling of NOMA-MIMO-Based Power Domain for 5G Network under Selective Rayleigh Fading Channels
Authors: Hassan Mohamed , Singh Manwinder , Hamid Khalid , Saeed Rashid , Abdelhaq Maha , Alsaqour Raed
Published: August 2022

The integration of multiple-input multiple-output (MIMO) and non-orthogonal multiple access (NOMA) technologies is a hybrid technology that overcomes a myriad of problems in the 5G cellular system and beyond, including massive connectivity, low latency, and high dependability. The goal of this paper is to improve and reassess the bit error rate (BER), spectrum efficiency (SE) of the downlink (DL), average capacity rate, and outage probability (OP) of the uplink (UL) in a 5G network using MIMO. The proposed model utilizes QPSK modulation, four users with different power location coefficients, SNR, transmit power, and two contrasting bandwidths 80 and 200 MHz under selective frequency Rayleigh fading channels. The proposed model’s performance is evaluated using the MATLAB software program. The DL results found that the BER and SE against transmitted power showed the MIMO-NOMA enhanced the BER performance for the best user U4 from 10−1.7 to 10−5.2 at 80 MHz bandwidth (BW), and from 10−1.5 to 10−5 at 200 MHz for transmitting power of 40 dBm. In contrast, the SE performance for the best user U4 is enhanced from 24 × 10−3 to 25 × 10−3 bits/second/Hz at 80 MHz BW and from 19.8 × 10−3 to 20 × 10−3 bps/Hz at 200 MHz BW. Although the outcomes for the UL were obtained in terms of average capacity rate and OP versus SNR at 80, and 200 MHz BW, the MIMO-NOMA result showed that the average capacity rate for the best user U4 performance improves by 12 bps/Hz for 1 dB SNR and the OP is reduced by 15 × 10−3 for 80 MHz BW and by 12 × 10−3 for 200 MHz BW at an SNR of 0.17 dB. As the BW increased the BER, the average capacity rate increased while the SE and OP decreased. For both DL/UL NOMA with and without MIMO, closed-form expressions for BER, SE, average capacity rate, and OP were obtained. All users’ performance, even those whose connections were affected by interference or Rayleigh fading channels significantly improved, when MIMO-NOMA was implemented.
Organizational Factors of Commitment to Innovation vs. Innovative Behavior in Smes in the Renewable Energy Sources (RES) Industry
Authors: Dzieńdziora Joanna , Smolarek Małgorzata , Żebrak Dawid , Gross-Gołacka Elwira
Published: August 2022

Innovation is one of the successful and competitive advantage factors for SMEs in the dynamically changing environment of the RES industry. For SMEs, innovation is driven by a number of factors, such as the size of the enterprise, the scope of activity, innovation capability, strategy, and environmental conditions. Organizations’ commitment to innovation is another important factor. This is especially true for SMEs with strong social bonds, meaning that every employee of the company is, to some extent, involved in the innovation process and influences the organization’s opinion. The goal of the paper is to assess the impact of organizational determinants of commitment to innovation on innovative behavior in SMEs in the RES industry. The paper is both theoretical and empirical. The theoretical part explains the relevance of organizational determinants of commitment to innovation and how they translate to innovative behavior in SMEs. The empirical part presents an analysis of the results of a quantitative diagnostic survey that involved a questionnaire comprised mostly of closed-ended questions. The survey lasted from September 2020 to February 2021 on a sample of 186 companies from the RES industry. Production workers participated in the survey. The survey was conducted in Poland. The research problem is expressed in the following questions: (1) Do organizational determinants of commitment to innovation influence innovative behaviors undertaken and implemented in SMEs in the RES industry? (2) What are the key predictors of organizational commitment to innovation in SMEs in the RES industry? (3) Which predictors of organizational commitment to innovation have the most influence on innovative behaviors undertaken and implemented in SMEs in the RES industry? The research hypothesis was as follows: The organizational factors of commitment to innovation have a positive impact on the innovative behaviors of employees. In the course of the survey, all the research assumptions were confirmed. The statistical tests were used to verify the research hypotheses. The article includes an introduction, literature review, analysis of research results, conclusions, and a bibliography.
Nomenclature Notes and Typification of Names in Dracaena (Asparagaceae, Nolinoideae)
Authors: Zhang Zhiyong , Idrees Muhammad , Zheng Xu , Jiao Yongqing , Prodhan Zakaria H.
Published: August 2022

Two new names, Dracaena neoparviflora and Dracaena ridleyii are proposed as replacement names for the illegitimate names D. parviflora Baker, and D. nutans Ridl., respectively, the latter being a later homonym of D. parviflora Willd. ex Schult.f., and D. nutans H.Jaeger. Lectotypes are designated for D.cambodiana, D. interrupta (synonym of D. camerooniana), D. oddonii (synonym of D. camerooniana), D. cantleyi, D. cinnabari, D. cuspidibracteata (synonym of D. congoensis), D. haemanthoides, D. litoralis (synonym of D. braunii), D. parviflora, D. novoguineensis, D. nutans, D. petiolata, D. reflexa var. linearifolia, D. reflexa var. angustifolia, D. steudneri, D. tessmannii (synonym of D. mannii), and D. viridiflora. The second-step lectotypications are made for D. camerooniana, D. bushii, D. glomerata, D. papahu (synonym of D. steudneri), D. talbotii (synonym of D. bicolor), D. vaginata (synonym of D. viridiflora), and D. xiphophylla. A neotype is designated for the name Aletris arborea (basionym of D. arborea).
Non-Premixed Filtered Tabulated Chemistry for LES: Evaluation on Sandia Flames D and E
Authors: Obando Vega Pedro Javier , Coussement Axel , Sadiki Amsini , Parente Alessandro
Published: August 2022

The non-premixed filtered tabulated chemistry for large eddy simulations employs numerical filtering to resolve a thin flame front on practical LES numerical grids. The flame structure is modified to be coherent with the domain discretization. The first turbulent combustion application of the non-premixed filtered tabulated chemistry approach is presented. A keen comparison of the flamelet filtering transformation in the premixed and non-premixed regimes is carried out. Three distinctive features are outlined: the flame thickness variation, the filtered manifold transformation, and the model activation dependence on the chosen diffusion flamelet configuration for a non-premixed filtered approach. The model performance is assessed on two real turbulent flame configurations, Sandia flames D and E, employing a three-dimensional tabulation strategy, where the numerical grid is coupled with the model by the third parameter, i.e., the computational cell size. The repercussions of the above cited aspects are carefully assessed. The results demonstrate that the formalism coupling with an SGS modeling function can adequately describe wrinkled flame front effects. The predictions for both the major stable species and the minor ones accurately correspond with the underlying physics. It turns out that there is a substantial variation of the filter effect as a function of the strain rate of the flame and the considered species. The varying filter sensitivity along the manifold influences the response of the model correction terms and the retrieved variables. The non-premixed FTACLES formalism possibilities and conditions for the model’s utilization and optimal performance are clearly stated, to confirm the idea that SGS closure in diffusive combustion can be derived based on filtering arguments, and not only based on statistical approaches.
Associations between Demographic Characteristics, Lifestyle Factors and School-Related Conditions and Symptoms of Mental Health Problems in Norwegian Upper Secondary School Students
Authors: Barene Svein , Ruud-Tronsmoen Andreas , Johansen Patrick Foss
Published: August 2022

Background: The purpose of this study was to evaluate the associations between demographic characteristics, lifestyle factors and school-related conditions, and symptoms of mental health problems in Norwegian upper secondary school students following the COVID-19 pandemic. Methods: In this cross-sectional study design we used a binary logistic regression model to evaluate potential associations between the predictors and dependent variable. Results: The following six predictors had a statistically significant impact on symptoms of mental health problems; gender effect of being a girl (p < 0.001), self-perceived body image (p < 0.001), sleep problems (p < 0.001), dietary habits (p = 0.033), school satisfaction (p = 0.013), and satisfaction with physical education (PE) class participation (p = 0.025). Conclusions: Being a girl was associated with a 315% higher probability of reporting symptoms of mental health problems than boys, whereas one unit increase in sleep problems showed a 192% higher probability of symptoms of mental health problems. Furthermore, a one unit increase on the respective beneficial predictors’ scales was associated with the following percentage having a lower probability of reporting symptoms of mental health problems; self-perceived body image (59%), dietary habits (58%), school satisfaction (82%), and satisfaction with PE class participation (68%).
The Impact of Internet Use on the Social Networks of the Elderly in China—The Mediating Effect of Social Participation
Authors: Zhang Qunlin , Li Zhibin
Published: August 2022

Introduction: Under the overlapping interaction of digitization and aging, the number of elderly Internet users has increased yearly. However, the impact of Internet use on the social networks of the elderly is still unclear. Methodology: In this study, we utilize the methods of ordinary least square regression (OLS), propensity score matching (PSM), instrumental variable (IV), and Bootstrap-mediated effect analysis methods using data from the Chinese General Social Survey (CGSS) to analyze the impact of Internet use on the social networks of the elderly and examine the mediating effect of social participation. Objectives: A total of 1363 validated respondents aged 60 or above were included to explore the relationship between Internet use, social networks, and social participation among the elderly in China. Results: The results show that Internet use positively and significantly impacts the social networks of the elderly. Compared to the elderly who do not use the Internet, the elderly who use the Internet have a larger social network size, more significant social network heterogeneity, and higher social network upper reachability. The mediated analysis shows that social participation plays a positive mediating role in the influence of Internet use on the social networks of the elderly. That is, Internet use will benefit the social network of the elderly by improving the level of their social participation. Besides, there also exists heterogeneity in the effect of Internet use on social networks among the elderly with different genders, ages, and places of residence. Conclusions: Internet use benefits the social network of the elderly, and social participation partially mediates the relationship between Internet use and the social network of the elderly. These findings have implications for formulating public policies aimed at active aging; it is necessary to bridge the “digital divide” and promote the digital integration of the elderly. Let more older adults benefit from Internet use, thus improving the social network and quality of life of the elderly.
An N-Shaped Association between Population Density and Abdominal Obesity
Authors: Sun Bindong , Yao Xiajie , Yin Chun
Published: August 2022

Abdominal obesity is a threat to public health and healthy cities. Densification may reduce abdominal obesity, but current evidence of the relationship between population density and abdominal obesity is not conclusive. The aim of this study was to disentangle the nonlinear association between population density and abdominal obesity. Data came from the 2004–2015 China Health and Nutrition Survey, which included 36,422 adults aged between 18 and 65 years. Generalized additive models (GAMs) were applied to explore how population density was associated with objectively measured waist circumference (WC) and waist-to-height ratio (WHtR), after controlling for other built environmental attributes, socioeconomic characteristics, and regional and year fixed effects. We found that population density had N-shaped associations with both WC and WHtR, and the two turning points were 12,000 and 50,000 people/km2. In particular, population density was positively correlated with abdominal obesity when it was below 12,000 people/km2. Population density was negatively associated with abdominal obesity when it was between 12,000 and 50,000 people/km2. Population density was also positively related to abdominal obesity when it was greater than 50,000 people/km2. Therefore, densification is not always useful to reduce abdominal obesity. Policy-makers need to pay more attention to local density contexts before adopting densification strategies.
Bayesian Modeling of COVID-19 to Classify the Infection and Death Rates in a Specific Duration: The Case of Algerian Provinces
Authors: Aouissi Hani Amir , Hamimes Ahmed , Ababsa Mostefa , Bianco Lavinia , Napoli Christian , Kebaili Feriel Kheira , Krauklis Andrey E. , Bouzekri Hafid , Dhama Kuldeep
Published: August 2022

COVID-19 causes acute respiratory illness in humans. The direct consequence of the spread of the virus is the need to find appropriate and effective solutions to reduce its spread. Similar to other countries, the pandemic has spread in Algeria, with noticeable variation in mortality and infection rates between regions. We aimed to estimate the proportion of people who died or became infected with SARS-CoV-2 in each provinces using a Bayesian approach. The estimation parameters were determined using a binomial distribution along with an a priori distribution, and the results had a high degree of accuracy. The Bayesian model was applied during the third wave (1 January–15 August 2021), in all Algerian’s provinces. For spatial analysis of duration, geographical maps were used. Our findings show that Tissemsilt, Ain Defla, Illizi, El Taref, and Ghardaia (Mean = 0.001) are the least affected provinces in terms of COVID-19 mortality. The results also indicate that Tizi Ouzou (Mean = 0.0694), Boumerdes (Mean = 0.0520), Annaba (Mean = 0.0483), Tipaza (Mean = 0.0524), and Tebessa (Mean = 0.0264) are more susceptible to infection, as they were ranked in terms of the level of corona infections among the 48 provinces of the country. Their susceptibility seems mainly due to the population density in these provinces. Additionally, it was observed that northeast Algeria, where the population is concentrated, has the highest infection rate. Factors affecting mortality due to COVID-19 do not necessarily depend on the spread of the pandemic. The proposed Bayesian model resulted in being useful for monitoring the pandemic to estimate and compare the risks between provinces. This statistical inference can provide a reasonable basis for describing future pandemics in other world geographical areas.
Groundwater Quality Assessment in the Northern Part of Changchun City, Northeast China, Using PIG and Two Improved PIG Methods
Authors: Wang Xinkang , Xiao Changlai , Liang Xiujuan , Li Mingqian
Published: August 2022

As a numerical indicator, the pollution index of groundwater (PIG) has gained a great deal of popularity in quantifying groundwater quality for drinking purposes. However, its weight-determination procedure is rather subjective due to the absolute dependence on experts’ experience. To make the evaluation results more accurate and convincing, two improved PIG models (CRITIC-PIG and Entropy-PIG) that integrate subjective weights and objective weights were designed, and they were employed to appraise groundwater suitability for drinking purposes in the northern part of Changchun City. A total of 48 water samples (34 unconfined water samples and 14 confined water samples) with abundances of Ca2+ and HCO3− were collected and tested to obtain the data for the analyses. The results showed that 60.4%, 47.9% and 60.4% of the water samples manifested insignificant pollution and were marginally potable based on the values of the PIG, CRITIC-PIG and Entropy-PIG, respectively. Though 48% of the water samples had different evaluation results, their level difference was mostly 1, which is relatively acceptable. The distribution maps of the three sets of PIG values demonstrated that the quality of groundwater was the best in Dehui City and the worst in Nongan County. Groundwater contamination in the study area was mainly caused by the high concentrations of TDS, TH, Fe3+, F− and NO3−, which not only came from geogenic sources but also anthropogenic sources.
“We’ve Always Been Kind of Kicked to the Curb”: A Mixed-Methods Assessment of Discrimination Experiences among College Students
Authors: Mahoney Cindy , Becerra Benjamin J. , Arias Devin , Romano Jacqueline E. , Becerra Monideepa B.
Published: August 2022

Background: Experiences of discrimination are prevalent among minority populations, although often empirical evidence does not provide depth into the source and types of discrimination, such as racial/ethnic, gender-based, age, etc. The goal of this study was to assess the unique patterns, types, and sources of discrimination experiences that college students face and explore the role these experiences play in their mental health. Methods: An explanatory sequential mixed-methods study was utilized. Quantitative assessment of college students from a Hispanic and minority-serving institution was conducted to evaluate experiences of discrimination and its association to physical health and mental health (including psychological distress), as well as food insecurity, a marker for poverty. Next, qualitative data were thematically analyzed to further provide an in depth understanding on the sources of such experiences, types of discriminations, as well as the impact on mental health. Results: Results of the quantitative assessment highlight that discrimination was prevalent among the population with a higher everyday discrimination score significantly associated with serious psychological distress, low mental health status, low physical health status, and being food insecure. Further, most of the participants reported that they felt discriminated due to their appearance, with race/ethnicity and skin color as next most commonly cited reasons. Qualitative assessment further demonstrates distinct types of discrimination experiences from a variety of sources. Within a family, colorism and having an American accent while speaking a native language was a predominant source, while among peers, having a non-American accent was a primary source of discrimination experiences. Such experiences based on elitism, gender, and age (being younger) from the workplace were prevalent among the target population. Finally, feelings of isolation, not belonging, as well as negative impact on self-efficacy and self-worth were noted. Conclusion: Experiences of discrimination are prevalent among college students, including from within family and peers. To improve mental health outcomes of such a population, campus-based measures are needed to promote resiliency and social support, as well as community-based initiatives to promote workplace training to create inclusive environments for younger generations entering the workforce.
Do You Mind? Examining the Impact of Psychoeducation Specificity on Perceptions of Mindfulness-Based Programs
Authors: Del Rosario Nicole , Beshai Shadi
Published: August 2022

Objective: Mindfulness-based programs (MBPs) cultivate the capacity for mindfulness, defined as nonjudgmental acceptance and awareness of present-moment experience. Mindfulness has been associated with a host of benefits for users, such as improved indices of mental well-being. We examined public perceptions of acceptability (i.e., how appropriate the treatment is for a given problem) and credibility (i.e., how logical and convincing a treatment seems) of MBPs as a form of mental health intervention. The main objective of this study was to examine whether higher specificity of psychoeducational content improved perceptions of the acceptability and credibility of MBPs. Methods: Participants (n = 188; female% = 39.4) were recruited online and randomly assigned to one of two conditions. In one condition, participants received balanced and evidence-based psychoeducation specific to MBPs for mental health. In the other condition, participants received general information about psychological treatments for mental health. Acceptability and credibility perceptions were measured by questionnaires across time (pre-and post-psychoeducation) and across specificity conditions (specific vs. general psychoeducation). Results: Participants randomized to the general, but not the specific, psychoeducation-endorsed higher scores of acceptability of MBPs post-psychoeducation. Further, participants endorsed higher scores of MBP credibility post-psychoeducation, regardless of the specificity of psychoeducation provided. Conclusions: Perceptions of the acceptability of MBPs were improved following exposure to general psychoeducation, and perceptions of the credibility of MBPs were improved following psychoeducation, regardless of specificity. Examining public perceptions of MBPs is important for informing strategies to support access to and use of MBPs.
Selective Recovery of Cadmium, Cobalt, and Nickel from Spent Ni–Cd Batteries Using Adogen® 464 and Mesoporous Silica Derivatives
Authors: Weshahy Ahmed R. , Sakr Ahmed K. , Gouda Ayman A. , Atia Bahig M. , Somaily H. H. , Hanfi Mohamed Y. , Sayyed M. I. , El Sheikh Ragaa , El-Sheikh Enass M. , Radwan Hend A. , Cheira Mohamed F. , Gado Mohamed A.
Published: August 2022

Spent Ni–Cd batteries are now considered an important source for many valuable metals. The recovery of cadmium, cobalt, and nickel from spent Ni–Cd Batteries has been performed in this study. The optimum leaching process was achieved using 20% H2SO4, solid/liquid (S/L) 1/5 at 80 °C for 6 h. The leaching efficiency of Fe, Cd, and Co was nearly 100%, whereas the leaching efficiency of Ni was 95%. The recovery of the concerned elements was attained using successive different separation techniques. Cd(II) ions were extracted by a solvent, namely, Adogen® 464, and precipitated as CdS with 0.5% Na2S solution at pH of 1.25 and room temperature. The extraction process corresponded to pseudo-2nd-order. The prepared PTU-MS silica was applied for adsorption of Co(II) ions from aqueous solution, while the desorption process was performed using 0.3 M H2SO4. Cobalt was precipitated at pH 9.0 as Co(OH)2 using NH4OH. The kinetic and thermodynamic parameters were also investigated. Nickel was directly precipitated at pH 8.25 using a 10% NaOH solution at ambient temperature. FTIR, SEM, and EDX confirm the structure of the products.
Lobelia chinensis Extract and Its Active Compound, Diosmetin, Improve Atopic Dermatitis by Reinforcing Skin Barrier Function through SPINK5/LEKTI Regulation
Authors: Park No-June , Jo Beom-Geun , Bong Sim-Kyu , Park Sang-a , Lee Sullim , Kim Yong Kee , Yang Min Hye , Kim Su-Nam
Published: August 2022

The skin acts as a mechanical barrier that protects the body from the exterior environment, and skin barrier function is attributed to the stratum corneum (SC), which is composed of keratinocytes and skin lipids. Skin barrier homeostasis is maintained by a delicate balance between the differentiation and exfoliation of keratinocytes, and keratinocyte desquamation is regulated by members of the serine protease kalikrein (KLK) family and their endogenous inhibitor SPINK5/LEKTI (serine protease inhibitor Kazal type 5/lympho-epithelial Kazal-type-related inhibitor). Furthermore, SPINK5/LEKTI deficiency is involved in impaired skin barrier function caused by KLK over-activation. We sought to determine whether increased SPINK5/LEKTI expression ameliorates atopic dermatitis (AD) by strengthening skin barrier function using the ethanol extract of Lobelia chinensis (LCE) and its active compound, diosmetin, by treating human keratinocytes with UVB and using a DNCB-induced murine model of atopic dermatitis. LCE or diosmetin dose-dependently increased the transcriptional activation of SPINK5 promoter and prevented DNCB-induced skin barrier damage by modulating events downstream of SPINK5, that is, KLK, PAR2 (protease activated receptor 2), and TSLP (thymic stromal lymphopoietin). LCE or diosmetin normalized immune response in DNCB treated SKH-1 hairless mice as determined by reductions in serum immunoglobulin E and interleukin-4 levels and numbers of lesion-infiltrating mast cells. Our results suggest that LCE and diosmetin are good candidates for the treatment of skin barrier-disrupting diseases such as Netherton syndrome or AD, and that they do so by regulating SPINK5/LEKTI.
PbXND1 Results in a Xylem-Deficient Dwarf Phenotype through Interaction with PbTCP4 in Pear (Pyrus bretschneideri Rehd.)
Authors: Xiao Yuxiong , Sha Guangya , Wang Di , Gao Rui , Qie Bingqing , Cong Liu , Zhai Rui , Yang Chengquan , Wang Zhigang , Xu Lingfei
Published: August 2022

Dwarfing is an important agronomic characteristic in fruit breeding. However, due to the lack of dwarf cultivars and dwarf stocks, the dwarfing mechanism is poorly understood in pears. In this research, we discovered that the dwarf hybrid seedlings of pear (Pyrus bretschneideri Rehd.), ‘Red Zaosu,’ exhibited a xylem-deficient dwarf phenotype. The expression level of PbXND1, a suppressor of xylem development, was markedly enhanced in dwarf hybrid seedlings and its overexpression in pear results in a xylem-deficient dwarf phenotype. To further dissect the mechanism of PbXND1, PbTCP4 was isolated as a PbXND1 interaction protein through the pear yeast library. Root transformation experiments showed that PbTCP4 promotes root xylem development. Dual-luciferase assays showed that PbXND1 interactions with PbTCP4 suppressed the function of PbTCP4. PbXND1 expression resulted in a small amount of PbTCP4 sequestration in the cytoplasm and thereby prevented it from activating the gene expression, as assessed by bimolecular fluorescence complementation and co-location analyses. Additionally, PbXND1 affected the DNA-binding ability of PbTCP4, as determined by utilizing an electrophoretic mobility shift assay. These results suggest that PbXND1 regulates the function of PbTCP4 principally by affecting the DNA-binding ability of PbTCP4, whereas the cytoplasmic sequestration of PbTCP4 is only a minor factor. Taken together, this study provides new theoretical support for the extreme dwarfism associated with the absence of xylem caused by PbXND1, and it has significant reference value for the breeding of dwarf varieties and dwarf rootstocks of the pear.
It Is Time for Senescience
Authors: Mattace-Raso Francesco
Published: August 2022

Aging is the most impressive demographic phenomenon in human history [...]
Proadrenomedullin in the Management of COVID-19 Critically Ill Patients in Intensive Care Unit: A Systematic Review and Meta-Analysis of Evidence and Uncertainties in Existing Literature
Authors: Montrucchio Giorgia , Balzani Eleonora , Lombardo Davide , Giaccone Alice , Vaninetti Anna , D’Antonio Giulia , Rumbolo Francesca , Mengozzi Giulio , Brazzi Luca
Published: August 2022

Mid-regional proadrenomedullin (MR-proADM) is a new biomarker of endothelial damage and its clinical use is increasing in sepsis and respiratory infections and recently in SARS-CoV-2 infection. We conducted a systematic review and meta-analysis to clarify the use of MR-proADM in severe COVID-19 disease. After Pubmed, Embase, and Scopus search, registries, and gray literature, deduplication, and selection of full-texts, we found 21 studies addressing the use of proadrenomedullin in COVID-19. All the studies were published between 2020 and 2022 from European countries. A total of 9 studies enrolled Intensive Care Unit (ICU) patients, 4 were conducted in the Emergency Department, and 8 had mixed populations. Regarding the ICU critically ill patients, 4 studies evaluating survival as primary outcome were available, of which 3 reported completed data. Combining the selected studies in a meta-analysis, a total of 252 patients were enrolled; of these, 182 were survivors and 70 were non-survivors. At the admission to the ICU, the average MR-proADM level in survivor patients was 1.01 versus 1.64 in non-survivor patients. The mean differences of MR-proADM values in survivors vs. non-survivors was −0.96 (95% CI from −1.26, to −0.65). Test for overall effect: Z = 6.19 (p < 0.00001) and heterogeneity was I2 = 0%. MR-proADM ICU admission levels seem to predict mortality among the critical COVID-19 population. Further, prospective studies, focused on critically ill patients and investigating a reliable MR-proADM cut-off, are needed to provide adequate guidance to its use in severe COVID-19.
Do Sex/Gender and Menopause Influence the Psychopathology and Comorbidity Observed in Delusional Disorders?
Authors: González-Rodríguez Alexandre , Seeman Mary V. , Díaz-Pons Alexandre , Ayesa-Arriola Rosa , Natividad Mentxu , Calvo Eva , Monreal José A.
Published: August 2022

Background: While sex differences and gonadal hormone levels are taken seriously in the understanding and treatment of schizophrenia, their influence in the psychopathology of delusional disorders (DD) remains unknown. Methods: Our strategy was to conduct a narrative review of the effects of (a) sex/gender difference and (b) menopause on delusional content, affective and anxiety-related comorbidity, substance use disorders, cognition, aggressivity, and suicide risk in DD. Results: Because the literature is scarce, our results are tentative. We found that erotomania was more prevalent in women than in men, and especially in women with premenopausal onset. In contrast, jealous and somatic delusions were more commonly seen in DD women with postmenopausal onset. With respect to depressive comorbidity, women with premenopausal onset appear more vulnerable to depression than those with later onset. Age at menopause is reported to correlate positively with intensity of suicidal ideation. Anxiety symptoms may be related to estrogen levels. Men present with higher rates of substance use disorders, particularly alcohol use. Conclusions: Many male/female differences in DD may be attributable to sociocultural factors but menopause, and, therefore, levels of female hormones, influence symptom expression in women and mediate the expression of psychiatric comorbidities. Further research in this area promises to lead to improved individualized treatment.
Impact of Sleep-Disordered Breathing Treatment on Ventricular Tachycardia in Patients with Heart Failure
Authors: Gerçek Muhammed , Gerçek Mustafa , Alzein Kanjo , Sciacca Vanessa , Sohns Christian , Sommer Philipp , Rudolph Volker , Fox Henrik
Published: August 2022

Background: Sleep-disordered breathing (SDB) is a highly common comorbidity in patients with heart failure (HF), and a known risk factor for ventricular tachycardia (VT) development. However, little is known about the impact of SDB treatment on VT burden in HF patients to date. Therefore, this study investigated VT burden, as well as implantable cardioverter-defibrillator (ICD) therapies in HF patients with SDB treatment, in comparison to untreated SDB HF patients. Methods: This retrospective study analyzed VT burden, rate of antitachycardia pacing (ATP), and the number of shocks delivered in a propensity score-matched patient cohort of patients with SDB treatment or control. Patients had moderate or severe SDB (n = 73 per each group; standardized mean difference of 0.08) and were followed for a minimum of one year. In addition, survival over 4 years was assessed. Results: Mean patient age was 67.67 ± 10.78 and 67.2 ± 10.10, respectively, with 15.06% and 10.95% of the patients, respectively, being female. Regarding SDB subtypes in the control and SDB treatment group, central sleep apnea was present in 42.46% and 41.09% of the patients, respectively, and obstructive sleep apnea was present in 26.02% and 31.50% of the patients, respectively. Mixed type sleep disorder was present in 31.50% and 27.40% of cases. Among the SDB treatment group, a significantly lower number of VTs (28.8% vs. 68.5%; p = 0.01), ATP (21.9% vs. 50.7%; p = 0.02), as well as a lower shock rate (5.5% vs. 31.5%; p < 0.01), was observed compared to the control group. Furthermore, the VT burden was significantly lower in the SDB treatment group when compared to the time prior to SDB treatment (p = 0.02). Event-free survival was significantly higher in the SDB treatment group (Log-rank p < 0.01). Conclusion: SDB treatment in HF patients with ICD leads to significant improvements in VT burden, ATP and shock therapy, and may even affect survival. Thus, HF patients should be generously screened for SDB and treated appropriately.
The Paradox of Pulmonary Vascular Resistance: Restoration of Pulmonary Capillary Recruitment as a Sine Qua Non for True Therapeutic Success in Pulmonary Arterial Hypertension
Authors: Langleben David , Orfanos Stylianos E. , Fox Benjamin D. , Messas Nathan , Giovinazzo Michele , Catravas John D.
Published: August 2022

Exercise-induced increases in pulmonary blood flow normally increase pulmonary arterial pressure only minimally, largely due to a reserve of pulmonary capillaries that are available for recruitment to carry the flow. In pulmonary arterial hypertension, due to precapillary arteriolar obstruction, such recruitment is greatly reduced. In exercising pulmonary arterial hypertension patients, pulmonary arterial pressure remains high and may even increase further. Current pulmonary arterial hypertension therapies, acting principally as vasodilators, decrease calculated pulmonary vascular resistance by increasing pulmonary blood flow but have a minimal effect in lowering pulmonary arterial pressure and do not restore significant capillary recruitment. Novel pulmonary arterial hypertension therapies that have mainly antiproliferative properties are being developed to try and diminish proliferative cellular obstruction in precapillary arterioles. If effective, those agents should restore capillary recruitment and, during exercise testing, pulmonary arterial pressure should remain low despite increasing pulmonary blood flow. The effectiveness of every novel therapy for pulmonary arterial hypertension should be evaluated not only at rest, but with measurement of exercise pulmonary hemodynamics during clinical trials.
Areal Analysis Investigation of Selective Laser Melting Parts
Authors: Boschetto Alberto , Bottini Luana , Ghanadi Nahal
Published: August 2022

Selective laser melting is an additive manufacturing technology used to fabricate metal parts characterized by complex geometries that are difficult or impossible to produce with conventional production methods. One of the major drawbacks of laser melting is the poor surface quality that typically is not satisfactory for functional applications. The aim of this work is to use areal analysis to characterize selective laser melting surfaces. The results highlight a marked variability and anisotropy that cannot be evaluated through traditional measurement. The building orientation and secondary finishing operations are analyzed and discussed. Findings demonstrate how areal analysis can be used to determine how to implement barrel finishing with the aim of reducing anisotropy and increasing surface quality.
Type 1A Endoleak after TEVAR in the Aortic Arch: A Review of the Literature
Authors: Scurto Lucia , Peluso Nicolò , Pascucci Federico , Sica Simona , De Nigris Francesca , Filipponi Marco , Minelli Fabrizio , Donati Tommaso , Tinelli Giovanni , Tshomba Yamume
Published: August 2022

Aortic arch repair is a challenging intervention. Open surgical repair is still considered the gold standard, but in high-risk patients, it is not always a reasonable option, making endovascular approaches an enticing, when not the only available, alternative for treatment. The strategies more commonly adopted are surgical supra-aortic trunk (SAT) rerouting followed by deployment of a standard thoracic endoprosthesis, chimney techniques, custom-made scalloped, fenestrated, and branched devices, and in situ or physician-modified fenestrations. If we excluded techniques involving SAT rerouting where the arch anatomy is surgically modified in order to make deployment in the aortic arch of a standard thoracic endoprosthesis possible, in the other techniques, one or more SATs are incorporated in the thoracic endoprosthesis. In these cases, no matter what solution is adopted, because of the morphology of the aorta at this level, achieving an ideal sealing is extremely difficult, and endovascular treatments of the arch are burdened by an increased risk of type IA endoleaks. PubMed, EMBASE, and Cochrane Library were searched. We identified 1277 records. After reading titles, abstracts, and full texts, we excluded 1231 records. Exclusion criteria were low-quality evidence, abstracts, case reports, conference presentations, reviews, editorials, and expert opinions. A total of 48 studies were included, for a total of 3114 patients. A type IA endoleak occurred in 248 patients (7.7%) with a mean incidence of 18.8% in chimney procedures, 4.8% and 3%, respectively, in fenestrated and branched devices, and 2.2% in in situ fenestration. We excluded from our analysis scalloped technology that is used when the target vessel originates from a healthy landing zone and represents a different anatomical setting. Type IA endoleaks are a concern with all types of endovascular aortic arch repair, and they can compromise the outcomes of the procedure. The rate of type IA endoleaks appears to be significantly higher in chimney procedures. In order to maximize sealing, whenever possible, endovascular repair of the arch should be achieved with custom-made fenestrated devices. However, chimney configurations are still a valuable solution particularly in the emergency setting, although in such a procedure, to guarantee accurate postoperative management and follow-up, an imaging protocol could be useful.
Forensic Dental Age Estimation: Development of New Algorithm Based on the Minimal Necessary Databases
Authors: Bjelopavlovic Monika , Zeigner Ann-Katrin , Hardt Jochen , Petrowski Katja
Published: August 2022

Objectives Dental age determination relies on the presence of wisdom teeth, which can be assigned to specific age ranges according to their stage of development. The purpose of this study is to highlight the applicability of the Demirjian staging of layman compared to expert, as well as the inclusion of all four wisdom teeth in the overall assessment, in order to emphasize and critically highlight a precise age estimation in clinical practice, especially in the case of agenesis or the presence of less than all four wisdom teeth. Material and Methods: In this study, dental age determination is performed and compared by a trained layperson and an expert using 385 orthopantomograms. The radiographs of known chronological age from male patients in the age range of 11–22 years were acquired from the University Medical Center Mainz. All four wisdom teeth were radiologically viewed if present. Demirjian staging with stages A–H was applied, and regression analysis was performed. Results: The relationship between mineralization of wisdom teeth (18, 28, 38 and 48) and age was linear for all teeth (p < 0.01), except for tooth 18 (p = 0.02). Comparing the prediction of the four teeth individually revealed that the lower teeth gave better predictions than the upper ones (R2 ≥ 0.50 vs. R2 < 0.50). Conclusions: For clinical use, the mandibular wisdom teeth should be preferred when performing dental age estimation using the Demirjian staging method. As a result of the present analysis, two ways of determining dental age by wisdom teeth can be suggested. One is to take only tooth 38, with the formula: age = 3.3 + 0.73 × mineralization of tooth_38. The second recommendation would be to take tooth_48. If both are unavailable, the formula would be age = −0.5 + 0.94 × mineralization tooth_28. Utilizing tooth 18 would not lead to more precise results.
The Role of Surgical Axillary Staging Prior to Immediate Breast Reconstruction in the Era of De-Escalation of Axillary Management in Early Breast Cancer
Authors: Svensson Miriam , Dihge Looket
Published: August 2022

Postmastectomy radiotherapy (PMRT) following immediate breast reconstruction (IBR) is associated with postoperative complications. Although the incidence of node-positive breast cancer is declining, a separate sentinel lymph node biopsy (SLNB) is still performed before mastectomy when IBR is planned, in order to evaluate nodal status and the need for PMRT. This study assessed the impact of staged SLNB on the breast reconstructive planning, and presents common clinicopathological characteristics of breast cancer with macrometastatic nodal spread where staged SLNB would be beneficial to indicate PMRT. Medical records of breast cancer patients scheduled for mastectomy and IBR at Skåne University Hospital, Sweden, from November 2014 to February 2020, were reviewed. Of 92 patients, node-positive disease was present in 15 (16%). Fifty-three patients underwent staged SLNB before mastectomy and IBR, and 10 (19%) presented with nodal metastasis. All patients with macrometastatic sentinel nodes were presented with palpable, multifocal, ER+ breast carcinoma of no special type with tumor size > 17.0 mm. Overall, four women received PMRT after verified metastasis by staged SLNB, and IBR was cancelled for three patients. These findings question the benefit of routine staged SLNB before mastectomy and IBR in breast cancer populations within established mammography screening programs with low risk of nodal metastasis.
The Heterogeneous Effects of Multilevel Location on Farmland Abandonment: A Village-Level Case Study in Tai’an City, China
Authors: Qiu Yingzhi , Cao Guangzhong
Published: August 2022

As a global phenomenon, farmland abandonment continues to challenge the sustainability of the agri-food supply and rural development. Investigating the heterogeneous effects of multilevel location on farmland abandonment is of great importance to understand the spatial disparity and the mechanism of farmland abandonment, which has significant policy implications for food security and rural revitalization. Taking Tai’an City as a case, this study aims to explore the impact of multilevel location on farmland abandonment at the village level and its spatial heterogeneity. The results show that (1) high accessibility to regional centers and roads, rather than remoteness, leads to a high rate of farmland abandonment; (2) the effect of location varies depending on the level of location. High-level regional centers (city centers and county centers) and roads (national and provincial highways) exert a stronger impact on farmland abandonment than low-level town centers and county highways; (3) the effect of location is topographically heterogeneous due to the influence of terrain on the marginalization of farmland. In the plains, except for county highways, the distance to different levels of regional centers and roads is significantly negatively correlated with farmland abandonment. However, in mountainous areas, only high-level regional centers have significant negative impacts.
Neobladder “Function”: Tips and Tricks for Surgery and Postoperative Management
Authors: Fasanella Daniela , Marchioni Michele , Domanico Luigi , Franzini Claudia , Inferrera Antonino , Schips Luigi , Greco Francesco
Published: August 2022

Orthotopic neobladder (ONB) reconstruction is a continent urinary diversion procedure increasingly used in patients with muscle-invasive bladder cancer following radical cystectomy (RC). It represents a valid alternative to the ileal duct in suitable patients who do not prefer a stoma and are motivated to undergo adequate training of the neobladder. Careful patient selection, taking into account the absolute and relative contraindications for ONB as well as an adequate recovery protocol after surgery are integral to the success of this procedure and the oncological and functional outcomes. The objective of this review is to summarize the current data on RC with ONB in terms of patient selection, preoperative preparation, surgical techniques and functional (continence and sexual activity) and oncological outcomes, with particular attention to the management of complications and the impact on quality of life (QoL).