bluuebunny/crossref_metadata_2025 huggingface dataset:
Invasive infections due to Saprochaete and Geotrichum species: Report of 23 cases from the FungiScope Registry
Authors: Durán Graeff Luisa , Seidel Danila , Vehreschild Maria J. G. T. , Hamprecht Axel , Kindo Anupma , Racil Zdenek , Demeter Judit , De Hoog Sybren , Aurbach Ute , Ziegler Maren , Wisplinghoff Hilmar , Cornely Oliver A. ,   FungiScope Group
Published: February 2017

Saprochaete and Geotrichum spp. are rare emerging fungi causing invasive fungal diseases in immunosuppressed patients and scarce evidence is available for treatment decisions. Among 505 cases of rare IFD from the FungiScope™ registry, we identified 23 cases of invasive infections caused by these fungi reported from 10 countries over a 12‐year period. All cases were adults and previous chemotherapy with associated neutropenia was the most common co‐morbidity. Fungaemia was confirmed in 14 (61%) cases and deep organ involvement included lungs, liver, spleen, central nervous system and kidneys. Fungi were S. capitata (n=14), S. clavata (n=5), G. candidum (n=2) and Geotrichum spp. (n=2). Susceptibility was tested in 16 (70%) isolates. All S. capitata and S. clavata isolates with the exception of one S. capitata (MIC 4 mg/L) isolate had MICs>32 mg/L for caspofungin. For micafungin and anidulafungin, MICs varied between 0.25 and >32 mg/L. One case was diagnosed postmortem, 22 patients received targeted treatment, with voriconazole as the most frequent first line drug. Overall mortality was 65% (n=15). Initial echinocandin treatment was associated with worse outcome at day 30 when compared to treatment with other antifungals (amphotericin B ± flucytosine, voriconazole, fluconazole and itraconazole) (P=.036). Echinocandins are not an option for these infections.
Surgical treatment of painful florid osseous dysplasia of the mandible: a case report
Authors: Ihbe J. , Müller S. , Smolka W.
Published: February 2017

A case is presented of a patient with painful bilateral mandibular florid osseous dysplasia without infection. The patient was edentulous. Surgical removal of the lesion led to total pain relief. To avoid long‐term drug abuse, surgical treatment might be an option to treat painful florid osseous dysplasia in selected cases especially in edentulous areas.
Practical approaches and costs for provisioning safe transfusions during anti‐CD38 therapy
Authors: Anani Waseem Q. , Marchan Marisela G. , Bensing Kathleen M. , Schanen Michael , Piefer Cindy , Gottschall Jerome L. , Denomme Gregory A.
Published: February 2017

BACKGROUND

Anti‐CD38 therapy causes interference with both the direct and the indirect antiglobulin tests. We describe the experience from an Immunohematology Reference Laboratory and model cost options for providing safe transfusions.

STUDY DESIGN AND METHODS

Phenotyping, genotyping, and antibody identification orders were retrospectively reviewed in the setting of anti‐CD38 therapy. The data were used to model the added cost of transfusion support. Four approaches were evaluated: 1) thiol‐treated reagent red blood cells (RRCs) in antibody investigations with K– red blood cell (RBC) transfusions, 2) patient phenotyping or 3) genotyping with antigen‐matched RBC transfusions, and 4) a combination of interval thiol‐treated RRC antibody investigations with genotype antigen–matched RBC transfusions.

RESULTS

Sixty‐two patients were identified as receiving anti‐CD38 therapy. Thiol‐treated RRC antibody investigations (28/62 patients) were favored over genotyping (23/62) and combination testing (11/62). Patient phenotyping failed to detect useful antigen information on eight patients: seven Fyb silencing mutations and one partial e. A thiol‐treated RRC antibody investigation was the least expensive testing method for the first transfusion, but four‐ and five‐antigen‐matched RBC transfusions were equal in cost within five and 21 transfusion events, respectively.

CONCLUSION

Genotyping provided a more accurate antigen status than phenotyping patient RBCs. Patients requiring long‐term transfusion support benefit from antigen matching when matching less than four antigens. Ultimately, the decision to genotype or use thiol‐treated RRC antibody investigations will vary for each hospital blood bank.
Individualized mini‐hemilaminectomy‐corpectomy (iMHC) for treatment of thoracolumbar intervertebral disc herniation in large breed dogs
Authors: Medl Susanne C. , Reese Sven , Medl Nikola S.
Published: February 2017

Objective

To assess the short‐term, mid‐term, and long‐term results after an individualized mini‐hemilaminectomy‐corpectomy (iMHC) procedure for treatment of acute and chronic thoracolumbar intervertebral disc disease in non‐chondrodystrophic dogs.

Study Design

Prospective study.

Animals

Client‐owned non‐chondrodystrophic large breed dogs (n = 57).

Methods

The iMHC procedure, combining mini‐hemilaminectomy (MH) and partial lateral corpectomy, was performed on non‐chondrodystrophic dogs with thoracolumbar disc disease. Neurological status was evaluated before surgery, for short‐term outcome on days 1 and 7 after surgery, for mid‐term outcome at 6 months after surgery, and for long‐term outcome at the conclusion of the study. Prognostic factors were statistically evaluated.P < .05 was considered significant.

Results

iMHC was performed on 57 dogs, with minimal intraoperative and postoperative complications. Short‐term neurological improvement was observed in 85.7% of dogs. Median hospitalization time after surgery was 2 days (range 0‐14) and was significantly shorter for dogs with a chronic history of clinical signs (1 day, range 0‐5) compared to acute onset (3 days, range 0‐14) and for those that were ambulatory at initial presentation (1 day, range 0‐5) compared to those that were not (3 days, range 0‐14). Long‐term evaluation included 53 surgeries with a mean follow‐up time of 29.4 months. Outcome was excellent in 19 dogs and good in 29 dogs (90.6% success rate). Excellent mid‐term and long‐term results were significantly more common in the dogs with only 1 affected disc space.

Conclusion

The iMHC procedure resulted in a short hospitalization time, minimal postoperative deterioration, and a high success rate.
Trajectory and Vibration Control of a Single-Link Flexible-Joint Manipulator Using a Distributed Higher-Order Differential Feedback Controller
Authors: Agee John T. , Bingul Zafer , Kizir Selcuk
Published: February 2017

The trajectory tracking in the flexible-joint manipulator (FJM) system becomes complicated since the flexibility of the joint of the FJM superimposes vibrations and nonminimum phase characteristics. In this paper, a distributed higher-order differential feedback controller (DHODFC) using the link and joint position measurement was developed to reduce joint vibration in step input response and to improve tracking behavior in reference trajectory tracking control. In contrast to the classical higher-order differential (HOD), the dynamics of the joint and link are considered separately in DHODFC. In order to validate the performance of the DHODFC, step input, trajectory tracking, and disturbance rejection experiments are conducted. In order to illustrate the differences between classical HOD and DHODFC, the performance of these controllers is compared based on tracking errors and energy of control signal in the tracking experiments and fundamental dynamic characteristics in the step response experiments. DHODFC produces better tracking errors with almost same control effort in the reference tracking experiments and a faster settling time, less or no overshoot, and higher robustness in the step input experiments. Dynamic behavior of DHODFC is examined in continuous and discontinues inputs. The experimental results showed that the DHODFC is successful in the elimination of the nonminimum phase dynamics, reducing overshoots in the tracking of such discontinuous input trajectories as step and square waveforms and the rapid damping of joint vibrations.
A Simple and Reliable Strategy for BK Virus Subtyping and Subgrouping
Authors: Morel Virginie , Martin Elodie , François Catherine , Helle François , Faucher Justine , Mourez Thomas , Choukroun Gabriel , Duverlie Gilles , Castelain Sandrine , Brochot Etienne
Published: February 2017

BK virus (BKV)-associated diseases in transplant recipients are an emerging issue. However, identification of the various BK virus subtypes/subgroups is a long and delicate process on the basis of currently available data. Therefore, we wanted to define a simple and effective one-step strategy for characterizing all BK virus strains from the VP1 gene sequence. Based on the analysis of 199 available complete DNA VP1 sequences, phylogenetic trees, alignments, and isolated polymorphisms were used to define an effective strategy for distinguishing the 12 different BK virus subtypes/subgroups. Based on the 12 subtypes identified from the 199 complete BKV VP1 sequences (1,089 bp), 60 mutations that can be used to differentiate these various subtypes/subgroups were identified. Some genomic areas were more variable and comprised mutational hot spots. From a subregion of only 100 bp in the VP1 region (1977 through 2076), we therefore constructed an algorithm that enabled rapid determination of all BKV subtypes/subgroups with 99% agreement (197/199) relative to the complete VP1 sequence. We called this domain of the BK viral genome the BK typing and grouping region (BKTGR). Finally, we validated our viral subtype identification process in a population of 100 transplant recipients with 100% efficiency. The new simpler method of BKV subtyping/subgrouping reported here constitutes a useful tool for future studies that will help us to more clearly understand the impact of BKV subtypes/subgroups on diagnosis, infection, and BK virus-associated diseases.
Reduced Potency and Incomplete Neutralization of Broadly Neutralizing Antibodies against Cell-to-Cell Transmission of HIV-1 with Transmitted Founder Envs
Authors: Li Hongru , Zony Chati , Chen Ping , Chen Benjamin K.
Published: February 2017

Broadly neutralizing antibodies (bNAbs) have been isolated from HIV-1 patients and can potently block infection of a wide spectrum of HIV-1 subtypes. These antibodies define common epitopes shared by many viral isolates. While bNAbs potently antagonize infection with cell-free virus, inhibition of HIV-1 transmission from infected to uninfected CD4+T cells through virological synapses (VS) has been found to require greater amounts of antibody. In this study, we examined two well-studied molecular clones and two transmitted/founder (T/F) clones for their sensitivities to a panel of bNAbs in cell-free and cell-to-cell infection assays. We observed resistance of cell-to-cell transmission to antibody neutralization that was reflected not only by reductions of antibody potency but also by decreases in maximum neutralization capacity relative to the levels seen with cell-free infections. BNAbs targeting different epitopes exhibited incomplete neutralization against cell-associated virus with T/F Envs, which was not observed with the cell-free form of the same virus. We further identified the membrane-proximal internal tyrosine-based sorting motif as a determinant that can affect the incomplete neutralization of these T/F clones in cell-to-cell infection. These findings indicate that the signal that affects surface expression and/or internalization of Env from the plasma membrane can modulate the presentation of neutralizing epitopes on infected cells. These results highlight that a fraction of virus can escape from high concentrations of antibody through cell-to-cell infection while remaining sensitive to neutralization in cell-free infection. The ability to fully inhibit cell-to-cell transmission may represent an important consideration in the development of antibodies for treatment or prophylaxis.

IMPORTANCEIn recent years, isolation of new-generation HIV-1 bNAbs has invigorated HIV vaccine research. These bNAbs display remarkable potency and breadth of coverage against cell-free virus; however, they exhibit a diminished ability to block HIV-1 cell-to-cell transmission. The mechanism(s) by which HIV-1 resists neutralization when transmitting through VS remains uncertain. We examined a panel of bNAbs for their ability to neutralize HIV-1 T/F viruses in cell-to-cell infection assays. We found that some antibodies exhibit not only reduced potency but also decreased maximum neutralization capacity orin vitroefficacy against cell-to-cell infection of HIV-1 with T/F Envs compared to cell-free infection of the same virus. We further identified the membrane-proximal internal tyrosine-based sorting motif YXXL as a determinant that can affect the incomplete neutralization phenotype of these T/F clones. When the maximum neutralization capacity falls short of 100%, this can have a major impact on the ability of antibodies to halt viral replication.
The Role of Touch in Acupuncture Treatment
Authors: Chae Younbyoung , Olausson Håkan
Published: February 2017

Acupuncture is a therapeutic treatment that is characterised by the insertion of a needle at a particular location on the body. Acupuncture stimulation includes sensory-discriminative and affective-social touch dimensions. In this review, we discuss the role of touch during acupuncture stimulation with an emphasis on the therapeutic, sensory-discriminative and affective-social aspects. In the discriminative dimension, de qi, which is associated with needling, includes a combination of various sensations, such as heaviness, numbness, soreness and distension. Achieving the appropriate de qi sensation appears to be fundamental to the therapeutic outcome following acupuncture treatment. In the affective dimension, the acupuncture procedure typically includes gentle manual touch stimulation, which induces feelings of calm and well-being, perhaps by activating C tactile fibres. Enhanced activity of C tactile afferents may induce a ‘limbic touch’ response, resulting in emotional and hormonal reactions. Because acupuncture is a ‘therapist intensive’ and complex intervention, it is necessary to understand the role of social touch between the practitioner and patient. Both sensory-discriminative and affective-social touch aspects play an important role in the therapeutic effect of acupuncture treatment in clinical practice.
DABCO as a green catalyst for the synthesis of pyranoquinoline derivatives
Authors: Ghorbani-Vaghei Ramin , Rahmatpour Farid , Sarmast Narges , Mahmoudi Jafar , Shahriari Azadeh
Published: February 2017

In this study, a rapid and convenient synthesis of quinolines was developed. The reaction involves a one-pot synthesis of pyranoquinoline derivatives from aldehyde, malonitrile, and 8-hydroxyquinoline using DABCO as a catalyst at 80 °C in H2O/EtOH as the solvent in good to high yields.
Implications of diphoton searches for a radion in the bulk-Higgs scenario
Authors: Cox Peter , Medina Anibal D. , Ray Tirtha Sankar , Spray Andrew
Published: February 2017

In this work, we point out that the apparent diphoton excess initially presented by the ATLAS and CMS collaborations could have originated from a radion in the bulk Higgs scenario within a warped extra dimension. In this scenario, the couplings of the radion to massive gauge bosons are suppressed, allowing it to evade existing searches. In the presence of mixing with the Higgs, due to the strong constraints from diboson searches, only points near what we denominate the alignment region were able to explain the diphoton signal and evade other experimental constraints. In light of the new measurements presented at ICHEP 2016 by both LHC collaborations, which do not confirm the initial diphoton excess, we study the current and future collider constraints on a radion within the bulk-Higgs scenario. We find that searches in the diphoton channel provide the most powerful probe of this scenario and already exclude large regions of parameter space, particularly for smaller warp factors. The radion has a sizeable branching ratio into top pairs and this channel may also give competitive constraints in the future. Finally, di-Higgs searches can provide a complementary probe in the case of nonzero radion-Higgs mixing but strong alignment.
Predicting the Grade of Dysplasia of Pancreatic Cystic Neoplasms Using Cyst Fluid DNA Methylation Markers
Authors: Hata Tatsuo , Dal Molin Marco , Hong Seung-Mo , Tamura Koji , Suenaga Masaya , Yu Jun , Sedogawa Hiraku , Weiss Matthew J. , Wolfgang Christopher L. , Lennon Anne Marie , Hruban Ralph H. , Goggins Michael G.
Published: February 2017

Purpose: Pancreatic cysts are common and pose diagnostic and management challenges. Pancreatic cyst fluid markers have the potential to aid in the management of cysts with concerning imaging findings. Our aim was to evaluate cyst fluid methylated DNA markers for their accuracy for predicting the histologic grade of neoplastic pancreatic cysts.

Experimental Design: Pancreatic cyst fluid samples from 183 patients (29 discovery and 154 validation) aspirated after surgical resection were analyzed for methylated DNA at selected genes (SOX17, BNIP3, FOXE1, PTCHD2, SLIT2, EYA4, and SFRP1) using methylation-specific droplet-digital PCR (dd-QMSP). Methylated DNA levels were evaluated for their accuracy at predicting the grade of dysplasia of the pancreatic cyst.

Results: All six markers evaluated in the validation set could accurately distinguish high-risk cystic neoplasms (with high-grade dysplasia and/or associated invasive cancer) from low-risk cysts (lower grades of dysplasia) with accuracies from 79.8% to 83.6%. Methylated SOX17 had the highest overall accuracy as a single marker (sensitivity, 78.4%; specificity, 85.6%; accuracy 83.6%, cutoff; 25 methylated DNA molecules/μL cyst fluid). The best four-gene combination had 84.3% sensitivity, 89.4% specificity, and 88.0% accuracy at distinguishing cysts with high-grade dysplasia and/or invasive cancer from those without. All six markers were independent predictors of having invasive cancer/high-grade dysplasia after adjusting for clinical/imaging factors known to be associated with grade of dysplasia. The combination of methylated SOX17 with cytology better predicted neoplastic grade than cytology alone.

Conclusions: A panel of methylated gene markers quantified by dd-QMSP can be used to predict the grade of dysplasia of pancreatic cysts. Clin Cancer Res; 23(14); 3935–44. ©2017 AACR.
Stroke Risk Factors, Genetics, and Prevention
Authors: Boehme Amelia K. , Esenwa Charles , Elkind Mitchell S.V.
Published: February 2017

Stroke is a heterogeneous syndrome, and determining risk factors and treatment depends on the specific pathogenesis of stroke. Risk factors for stroke can be categorized as modifiable and nonmodifiable. Age, sex, and race/ethnicity are nonmodifiable risk factors for both ischemic and hemorrhagic stroke, while hypertension, smoking, diet, and physical inactivity are among some of the more commonly reported modifiable risk factors. More recently described risk factors and triggers of stroke include inflammatory disorders, infection, pollution, and cardiac atrial disorders independent of atrial fibrillation. Single-gene disorders may cause rare, hereditary disorders for which stroke is a primary manifestation. Recent research also suggests that common and rare genetic polymorphisms can influence risk of more common causes of stroke, due to both other risk factors and specific stroke mechanisms, such as atrial fibrillation. Genetic factors, particularly those with environmental interactions, may be more modifiable than previously recognized. Stroke prevention has generally focused on modifiable risk factors. Lifestyle and behavioral modification, such as dietary changes or smoking cessation, not only reduces stroke risk, but also reduces the risk of other cardiovascular diseases. Other prevention strategies include identifying and treating medical conditions, such as hypertension and diabetes, that increase stroke risk. Recent research into risk factors and genetics of stroke has not only identified those at risk for stroke but also identified ways to target at-risk populations for stroke prevention.
Cardiovascular Health and Healthcare Utilization and Expenditures Among Medicare Beneficiaries: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study
Authors: Aaron Kristal J. , Colantonio Lisandro D. , Deng Luqin , Judd Suzanne E. , Locher Julie L. , Safford Monika M. , Cushman Mary , Kilgore Meredith L. , Becker David J. , Muntner Paul
Published: February 2017

Background

Better cardiovascular health is associated with lower cardiovascular disease risk.

Methods and Results

We determined the association between cardiovascular health and healthcare utilization and expenditures in the
RE
asons for Geographic And Racial Differences in Stroke (REGARDS) study. We included 6262 participants ≥65 years with Medicare fee‐for‐service coverage for the year after their baseline study visit in 2003‐2007. Cardiovascular health at baseline was assessed using the American Heart Association's Life's Simple 7 (
LS
7) metric, which includes 7 factors: cigarette smoking, physical activity, diet, body mass index, blood pressure, cholesterol, and glucose. Healthcare utilization and expenditures were ascertained using Medicare claims in the year following baseline. Overall, 17.2%, 31.1%, 29.0%, 16.4% and 6.4% of participants had 0 to 1, 2, 3, 4, and 5 to 7 ideal
LS
7 factors, respectively. The multivariable‐adjusted relative risk (95% confidence interval [
CI
]) for having any inpatient and outpatient encounters comparing participants with 5 to 7 versus 0 to 1 ideal
LS
7 factors were 0.55 (0.39, 0.76) and 1.00 (0.98, 1.02), respectively. Among participants with 0 to 1 and 5 to 7 ideal
LS
7 factors, mean inpatient expenditures were $3995 and $1250, respectively, mean outpatient expenditures were $5166 and $2853, respectively, and mean total expenditures were $9147 and $4111, respectively. After multivariable adjustment, the mean (95%
CI
) cost difference comparing participants with 5 to 7 versus 0 to 1 ideal
LS
7 factors was −$2551 (−$3667, −$1435) for inpatient, −$2410 (−$3089, −$1731) for outpatient, and −$5016 (−$6577, −$3454) for total expenditures.

Conclusions

Better cardiovascular health is associated with lower risk for inpatient encounters and lower inpatient and outpatient healthcare expenditures.
Osteology of Physalaemus nattereri (Anura: Leptodactylidae) with comments on intraspecific variation
Authors: FRATANI JÉSSICA , WOITOVICZ-CARDOSO MANOELA , LOURENÇO ANA CAROLINA CALIJORNE
Published: February 2017

The cranium, postcranium, and osteological variation of Physalaemus nattereri (Steindachner) are described. The main sources of variation involve the degree of mineralization of the nasal capsule and the lengths of dermal skull bones (e.g., vomer, sphenethmoid, and neopalatine). Osteologically, P. nattereri differs from its congeners by the anterior placement of the jaw articulation (which lies anterior to the intersection between the alae and cultriform process of parasphenoid), and by the separation of the frontoparietals from the anterior margins of exoccipitals. Descriptions of the nasal capsule, the auditory apparatus, and the iliosacral articulation are presented for the first time for this species. One putative morphological synapomorphy is presented for the P. signifer Clade.
Transient response of bilayered elastic strips with interfacial diffusion and sliding in cylindrical bending
Authors: Wang Xu , Wang Cuiying
Published: February 2017

Time-dependent deformations of bilayered elastic strips with interfacial diffusion and sliding in cylindrical bending are studied. A film–substrate system is also addressed by letting the thickness of one layer approach infinity. Our solution clearly indicates that the stresses and displacements in the strip evolve with two relaxation times when its upper surface is subjected to a sinusoidal pressure. Explicit and elementary expressions of the relaxation times are derived. The steady-state displacement jumps across the interface are found independent of the elastic property and thickness of the lower layer free of external loading. When the film is extremely thin, the relaxation times are independent of the elastic property of the substrate; when the film is extremely thick, the relaxation times are found independent of the film thickness. Detailed numerical results are presented to show the influence of the material, geometric and interface parameters on the relaxation times and on the evolving displacements and stresses in the strip or in the film–substrate system. Finally, the state-space method is proposed to determine the transient elastic field in simply supported multilayered elastic strips with interfacial diffusion and sliding under thermomechanical loads.
Promising evidence for nutrition interventions in people with serious mental illness
Authors: Meader Nick
Published: February 2017

People with serious mental illness (SMI) are more likely to engage in health risk behaviours such as unhealthy eating, physical inactivity and smoking. The review by Teasdale et al in this issue shows the potential for nutrition interventions to help people with SMI to manage their weight.
Fibular strut graft for nonunited femoral neck fractures in children
Authors: Elgeidi A. , El-Negery A.
Published: February 2017

Purpose

To evaluate the clinical and radiological outcomes of using fibular strut grafts as a fixation device for non-united femoral neck fractures in children with or without subtrochanteric valgus osteotomy.

Methods

A total of 12 children with non-united femoral neck fractures (nine males and three females) with an average age of 8.2 years (5 to 12) were managed, and functional results evaluated, between July 2013 and July 2015. The mechanisms of injury were fall from a height in ten patients and road traffic accident in two cases. Nine cases of femoral neck nonunion followed failed internal fixation and three cases were neglected fractures. Six cases were treated by fibular strut graft and subtrochanteric valgus osteotomy with contoured plate and six cases were treated by fibular strut graft and hip spica.

Results

The mean follow-up period was 20.4 months (12 to 36). Union was achieved in all 12 cases by a mean of 3.5 months (2.5 to 6). All patients were satisfied at five months. For final analysis of clinical and radiographic results, the Ratliff's classification was used. We classed 11 cases as good results and one case as fair.

Conclusions

Fibular strut grafts are a reliable option for treatment of pseudo-arthrosis in femoral neck fracture nonunion in children. It is successful in restoration of femoral neck length in children with non-united femoral neck fractures.
Proximal femoral osteotomy in children with cerebral palsy: The perspective of the trainee
Authors: Zhou L. , Camp M. , Gahukamble A. , Willoughby K. L. , Harambasic M. , Molesworth C. , Khot A. , Graham H. K.
Published: February 2017

Background

There are a range of implants for fixation of proximal femoral osteotomies (PFOs) in children. We investigated the training experiences and preferences of orthopaedic residents and fellows who were learning PFO, using a fixed angled blade plate (ABP) or a locking, cannulated blade plate (LCBP). We also studied short-term technical and radiographic outcomes.

Methods

This was a prospective, parallel-group, cohort study of 90 consecutive children and adolescents with cerebral palsy who underwent bilateral PFOs with ABP or LCBP. Surgical trainees completed a questionnaire to document the ease or difficulty of each operative step.

Results

There were 48 boys and 42 girls, with a mean age of eight years and a mean follow-up of 25 months. Trainees preferred the LCBP system for: insertion of the guidewire, the seating chisel and the blade plate, as well as overall technical ease of use (p < 0.001). Radiographic outcomes were similar with no between-group differences for migration percentage (p = 0.996) or neck shaft angle (p = 0.849), but there was a higher prevalence of technical errors in the ABP group.

Conclusions

Trainee surgeons expressed a preference for LCBPs when learning PFO in children with cerebral palsy. Radiographic outcomes were similar in both groups, with close attending surgeon supervision.
Characteristics exponents of the triangular solution in the elliptical restricted three-body problem under radiating and triaxial primaries
Authors: Narayan Ashutosh , Pandey Krishna Kumar , Shrivastava Sandip Kumar
Published: February 2017

This Paper deals with the effects of the radiation pressure and triaxiality of primaries on the stability of infinitesimal motion about triangular equilibrium points [ , ] in the elliptical restricted three body problem (ER3EB) around binary system. For determining the characteristic exponents of variational equations with periodic coefficient, we have used analytical method, described by Bennet in [3, 4]. This analytical method is based on Floquetâ€™s theory. The stability of equilibrium points has been discussed under the assumption thatboth the primaries are radiating and triaxial. For this we have drawn transition cureves in Î¼-e plane. And it is seen that system is stable outside the transition curves, while system is Unstable within the transition curves.
Periodic Variations in the Vertical Velocities of Galactic Masers
Authors: Bobylev V. V. , Bajkova A. T. , Shirokova K. S.
Published: February 2017

We compiled published data on Galactic masers with VLBI-measured trigonometric parallaxes and determined the residual tangential, ∆V
circ, and radial, ∆VR
, velocities for 120 masers. We used these data to redetermine the parameters of the Galactic spiral density wave using the method of spectral analysis. The most interesting result of this study is the detection of wavelike oscillations of vertical spatial velocities (W) versus distance R from the Galactic rotation axis. Spectral analysis allowed us to determine the perturbation wavelength and the amplitude of this wave, which we found to be equal to λ
W
= 3.4 ± 0.7 kpc and fW
= 4.9 ± 1.2 km s−1, respectively.
Russian Virtual Observatory: Data Sources
Authors: Malkov O. , Dluzhnevskaya O. , Bakanas E. , Kilpio E. , Kniazev A. , Kovaleva D. , Mironov A. , Pakhomov Yu. , Ryabchikova T. , Rykhlova L. , Sachkov M. , Sazonov S. , Zhukov A.
Published: February 2017

The purpose of this review is to analyze main directions of creation and functioning of major data sources developed by Russian astronomers or with their participation and to compare them with the worldwide trends in these fields. We discuss astronomical space missions of the past, present, and future (Astron, INTEGRAL, WSO-UV, Spectrum Roentgen Gamma, Lyra-B), high-quality photometric atlases and catalogues, and spectroscopic data sources, primarily VALD and the global VAMDC framework for the maintenance and distribution of atomic and molecular data. We describe collection, analysis, and dissemination of astronomical data on minor bodies of the Solar System and on variable stars. Also described is the project joining data for all observational types of binary and multiple stars, Binary star DataBase (BDB).
Creativity is a Label for the Aggregated, Time – Dependent, Subjective Judgments by Creators and by Adopters
Authors: Moran Seana
Published: February 2017

The first premise is that creativity requires a focal perceiver perspective to be determined or assigned. As criteria for perception or judgment, what we currently consider “dimensions” of creativity instead may be “precursors.” Ultimately, creativity shifts meaning for the whole culture. The second premise is that creativity requires a temporal perspective: its assessment is time-dependent on the first instance the perceiver notices. If the perceiver accepts the creative “ it,” then it is shared for others to judge it, creating a diffusion and adaptation process. The strongest form of creativity, then, is when it stands the test of time, goes beyond its own zeitgeist, and is institutionalized for future generations.
From Crisis to Creativity: Towards a Psychology of Creating
Authors: Wagoner Brady
Published: February 2017

The present paper argues that crisis talk has been rampant in psychology since its beginning. This is so because it serves a powerful rhetorical function – ‘if we are in crisis we must do x to get out of it’. In fact, being in crisis is the state of any progressive discipline, where new evidence is brought to light and new ideas are put on offer. This paper then turns to the specific conceptual and methodological issues facing the psychology of creativity and offers some suggestions for moving the sub-discipline forward. It proposes dropping the study of ‘creativity’ as a noun, and instead focusing on the concrete process of creating and evaluating the products of that activity.
Revisiting the Systems Approach: Commentary on Glăveanu’s Paper “The Psychology of Creativity: A Critical Reading”
Authors: Tang Min
Published: February 2017

In responding to Glăveanu’s critical views on the psychology of creativity, this commentary summarizes seminal work that has been carried out on creativity since 1950s. It underscores the value of the systems approach and discusses key methodological issues related to this approach, including creativity assessment, the necessity for multi-level analyses, the bandwidth-fidelity-dilemma, the challenge of operationalizing creativity for empirical studies and the lack of communication across disciplines. It calls for more external support, cross-disciplinary and cross-cultural collaboration and the establishment of a more open, tolerant and creativity-conducive environment to encourage and unleash creativity in creativity research from creativity researchers.
„And What is a Beautiful Poem”? Reflections of a Poet on Vlad Petre Glăveanu’s The Psychology of Creativity: A Critical Reading
Authors: Citko Katarzyna
Published: February 2017

I fully subscribe to Glăveanu’s opinions. I am not a psychologist, but as someone who specialises in culture and at the same time, as a poet, I believe that if the psychology of creativity is to say something truthful about the creative process, it should open up to the inner life of artists and to statistically unmeasurable processes such as talent and inspiration, rather than devise and carry out laboratory experiments. Therefore, encouraged by Glăveanu to pose innovative questions, in my article I ask about the essence of poetic inspiration, that is able to create images and lies at the root of metaphor which emerges in the mind of an artist.
Creativity in Somebody Else's Shoes
Authors: Witerska Kamila
Published: February 2017

The paper describes creativity in role context and how drama features and techniques can stimulate creative thinking. The first part of the article concerns the role of drama as a stimulator by encasing the participant in fiction. Aspects of development are also taken into account and the areas of differences in the use of drama at various stages of development, and thus at different stages of education are highlighted. The second part of the paper is devoted to drama techniques - heuristics based on taking on a role. The last part of the article describes how drama stimulates the process of solving problems and delineates its specificity.
Popular Author of Popular Art
Authors: Jaworski Marcin
Published: February 2017

The article provides a report on research conducted on the creative activity of Jerzy Wróblewski, a Polish author of comics published in the book „Urodzony, żeby rysować”. Twórczość komiksowa Jerzego Wróblewskiego, “Born to Draw.” Jerzy Wróblewski’s Comic Art (Jaworski, 2015). It is the first study of this kind in Poland. From this point of view, it contains not only a body of knowledge in the form of a monograph of the comic writer’s artistic creativity, but it also includes a developed research model. The structure of this model, combining traditional monographic narrative with broad historical, political and social context, can be used in the analyses of artistic accomplishments of other authors of Polish comics. The presented study addresses the need for scientific explorations in this field, but also for raising the value of those parts of Polish modern culture which were marginalised as ‘worse’ for many years, first for political reasons, then for cultural ones. It appears that the time has come to examine critically the artistic creativity of important figures of Polish popular culture (in this case of comics) objectively and without ideological prejudice, and recognise them as full authors of Polish culture. Jerzy Wróblewski is among them and that is why the book is about him.
The classifications of quaternionic osculating curves in ℚ4
Authors: Yildirim Yilmaz Münevver , Kulahci Mihriban
Published: February 2017

In this work, we define a quaternionic osculating curves and give the conditions for curves to be osculating with the help of curvature functions.
Estudio comparativo de la autonomía funcional de adultos mayores: atletas y sedentarios, en altitud moderada
Authors: Quintero-Burgos Cesar Giovanni , Melgarejo-Pinto Víctor Manuel , Ospina-Díaz Juan Manuel
Published: February 2017

La práctica sistemática de actividad física contribuye al mejoramiento de las condiciones de vida y salud y retarda el proceso de envejecimiento del adulto mayor. Objetivo. Identificar diferencias en la autonomía funcional en hombres de 60 a 70 años, practicantes de ciclismo y sedentarios, residentes en Tunja, a altitud moderada. Materiales y Métodos. Estudio comparativo de corte transversal analítico. Participaron 22 adultos mayores, de sexo masculino; 11 sedentarios y 11 practicantes de ciclo montañismo, con edades entre 60 y 70 años (media 63.03±4.32 años) previo consentimiento informado se sometieron a evaluación cineantropomé- trica por bioimpedancia, las pruebas de la batería Senior Fitness Test (SFT) de Rikli y Jones (1999a) el Test de Ästrand submaximal y dinamometría manual derecha e izquierda. Resultados: Los grupos se encontraron comparables en edad, peso, talla e índice de masa corporal (p>0,05). Se registraron diferencias estadísticamente significativas a favor del grupo de ciclo montañistas, en la media del porcentaje de grasa corporal, densidad ósea, masa muscular, mientras que ni el índice de masa corporal (25,6 ±3,3 y 25,2±2,5) registraron diferencias significativas. En la prueba SFT se encontraron diferencias estadísticamente significativas en la flexión de cadera (p<0,001). En la prueba submaximal se encontraron diferencias estadísticamente significativas en la prueba de esfuerzo en Watts (p=0,021). En la dinamometría de la mano izquierda también se encontraron diferencias estadísticamente significativas (p=0,0007). Conclusión. Los adultos mayores que adelantan rutinariamente prácticas de ejercicio físico como el ciclo montañismo presentan mejores características de composición corporal, flexibilidad de la cintura, mejor capacidad aeróbica y motricidad.
VAKSIN MVA85A UNTUK PENCEGAHAN TUBERKULOSIS PADA WISATAWAN
Authors: Quedarusman Hermanto
Published: February 2017

Tuberkulosis adalah penyakit menular yang dapat menyebar melalui udara, penyakit ini menyebabkanÂ kerusakan serius yang dapat menpengaruhi paru-paru, otak, dan organ lainnya. Tuberkulosis telahÂ menyebabkan bencana signifikan yang berhubungan dengan morbiditas dan mortalitas di dunia danÂ merupakan salah satu penyebab kematian utama di Indonesia. Teknologi terkini yang maju dalamÂ bepergian dari negara ke negara Â  menyebabkan penyakit ini mampu menyebar dari populasi endemik keÂ luar negeri. Vaksinasi adalah salah satu cara yang mungkin untuk mencegah terjadinya hal ini, vaksinÂ terbaru MVA-85A dari Universitas Oxford adalah alternatif terbaru untuk melawan tuberkulosis.Â Wisatawan jangka panjang memiliki kesempatan lebih besar untuk terjadinya kontak dengan penyakitÂ ini, terutama pada balita di bawah 4 tahun. Tidak ada kesepakatan tentang metode untuk mencegahÂ menyebarnya penyakit ini, tetapi ada banyak strategi yang bisa mencegah menyebarnya penyakit iniÂ termasuk menghindari kontak, vaksinasi BCG, dan alternatif lainnya. Dalam penelitian di UniversitasÂ Oxford, vaksin baru utnuk melawan tuberkulosis ditemkan dan saat ini sedang menjalani percobaanÂ klinis untuk membuktikan keamanan dan imunogenitasnya di beberapa kelompok orang. Vaksin iniÂ disebut MVA-85A dan dari beberapa percobaan klinis terbukti aman dan imunogenik. Vaksin ini bisaÂ menjadi salah satu cara yang memungkinkan untuk mencegah wisatawan terinfeksi tuberkulosis.
BAHAYA LATEN INFEKSI GONORE DAN KLAMIDIA DI ASIA SELATAN & ASIA TENGGARA, DI INDONESIA DAN KOTA MANADO
Authors: Pirade Aron
Published: February 2017

Prevalensi STI (Sexual Transmitted Infection) khususnya Gonore dan Klamidia di duniamenempati urutan tertinggi. Wilayah Asia Selatan dan Asia Timur-Selatan (juga disebut AsiaÂ Tenggara) adalah wilayah dengan prevalensi Gonore dan Klamidia terbesar. Prevalensi Gonore diÂ tahun 1995 dan 1999 yaitu 29.11 dan 27.2 juta penduduk wilayah Asia Selatan dan Asia Tenggara.Â Klamidia, di tahun 1995 dan tahun 1999 yaitu 40.48 dan 42.89 juta penduduk wilayah Asia SelatanÂ dan Asia Tenggara. Di Indonesia sendiri, pada 11 area penelitian menunjukkan bahwa prevalensiÂ Gonore dalam wilayah Indonesia menunjukkan rata-rata prosentasenya 20%-40% dari keseluruhanÂ STI pada wanita beresiko tinggi terkena STI. Sedangkan infeksi oleh Klamidia prosentasenya 15%-Â 45% dari keseluruhan STI pada wanita beresiko tinggi terkena penyakit kelamin. Prosentase GonoreÂ dan Klamidia di Kota Manado rata-rata 15-30%. Tingginya prevalensi infeksi Gonore dan Klamidia diÂ Asia Tenggara, ternyata diikuti juga dengan tingginya perkembangan infeksi Gonore dan Klamidia diÂ Indonesia dan Kota Manado.
INFEKSI SALURAN KEMIH PADA GERIATRI
Authors: Torayraju Kokeela
Published: February 2017

Jumlah penderita infeksi saluran kemih (ISK) pada geriatri di Indonesia akan semakin meningkat dan menjadipenyebab kedua tersering setelah pneumonia. Pendekatan diagnosis dan terapi ISK pada geriatri memilikikekhususan. Ada tidaknya gejala dan tanda spesifik serta bagaimana cara pengambilan spesimen turutberperan dalam diagnosis ISK pada geriatri. Faktor predisposisi penderita ISK pada geriatri meliputi diabetesmelitus, gizi kurang, gangguan faal kognitif, depresi, gangguan status fungsional, prostatitis, riwayat operasi,dan prolaps vagina. Gejala dan tanda yang sering muncul adalah sindrom delirium, inkontinensia urin dansyncope yang diawali oleh penurunan nafsu makan. Strategi penatalaksanaan meliputi modalitas nonâ€farmakologik dan farmakologik.Â
GAMBARAN PENGETAHUAN IBU BALITA MENGENAI DIARE DI DESA BUNGAYA KECAMATAN BEBANDEM KABUPATEN KARANGASEM OKTOBER 2013
Authors: Bin Hamdan Hafiz
Published: February 2017

Diare merupakan masalah kesehatan masyarakat dan masih tergolong salah satu dari sepuluh penyakit penyebab kematian di Indonesia. Pada tahun 2007 terdapat kejadian luar biasa (KLB) pada bulan Februariâ€Maret 2007 di Kabupaten Karangasem, dimana tercatat insiden diare sebesar 574 kasus, dan jumlah kematian wargapenderita diare sebanyak 6 orang. Penelitian ini bertujuan untuk mengukur gambaran pengetahuan ibu balita mengenai diare di Desa Bungaya. Penelitian ini dilakukan pada bulan oktober 2013 dengan menggunakan rancangan crossâ€sectional deskriptif. Data diperoleh dari wawancara berstruktur dengan kuisioner. Responden penelitian ditargetkan 50 ibu yang memiliki balita di Desa Bungaya yang dipilih secara simple random sampling. Data yang diperoleh di analisis menggunakan program SPSS 16.0 dan disajikan dalam bentuk tabel dan narasi. Berdasarkan analisis dan pembahasan ditemukan kejadian diare pada Balita di Desa Bungaya, yaitu sebesar 80%. Dari faktor risiko yang diteliti, didapati 52% responden mempunyai pengetahuan kurang tentang diare.Â
EFEKTIFITAS TUBEX SEBAGAI METODE DIAGNOSIS CEPAT DEMAM TIFOID
Authors: Yoga Pratama Krisna , Lestari Wiradewi
Published: February 2017

Typhoid fever is caused by Salmonella typhii or Salmonella paratyhpii. Many diagnostic methods have been developed to find the fastest, easiest, and cheapest way to achieve the highest sensitivity and specificity. A method that can diagnose fast and good sensitivity and specificity is TUBEX test. TUBEX test is a serologic test that detects immunoglobulin M against specific antigen O9 S.typhii. This test use semiâ€quantitative agglutination competitive method with colored particle.
PREVALENSI HIPERTENSI DAN KEBIASAAN MEROKOK, KONSUMSI ALKOHOL, SERTA KONSUMSI GARAM PADA PENDUDUK USIA 20-59 TAHUN DI WILAYAH KERJA UPTD PUSKESMAS KUBU II
Authors: Priyadarshini Uttari
Published: February 2017

From the report of UPTD Puskesmas Kubu II in 2012, hypertension was one of the tenmost frequent illnesses in their working area. Hypertension is connected with smoking habit, alcohol and salt consumption. The purpose of this study is to describe the prevalence of hypertension and smoking habit, consumption of alcohol and salt among the villagers in the working area of UPTD Puskesmas Kubu II. This research was conducted in August 2012 atworking area of UPTD Puskesmas Kubu II with a cross-sectional study design which was participated by 80 samples within 20-59 years old. Data were collected directly using an anthropometric measurements, blood pressure measurement and questionnaires. The result showed that hypertension tends to affect villagers who drinkalcohol â‰¥ 7 times per week and smoke>20ciggarettes per day. We may conclude that the prevalence of hypertension among villagersinworking area of UPTD Puskesmas Kubu IIis quite high. There are also tendencies of bad habit regarding risk factor of hypertension. This requires further attention.
GAMBARAN RIWAYAT MEROKOK, KONSUMSI ALKOHOL, DAN HIPERTENSI KELUARGA PADA PENDERITA HIPERTENSI DI WILAYAH KERJA PUSKESMAS MANGGIS I KABUPATEN KARANGASEM BALI 2013
Authors: Saputra Windhu , Seriani Luh , Sudinda Ketut
Published: February 2017

Hypertension is a chronic disease which diagnosed by increased blood pressure above normal value. From Riskesas study on 2010, the hypertension cases was affect around 8,4 million people. On manggis district itself, the prevalence of hypertension cases on their area of duty was increased from 150 cases to 320 cases in 2013. The most determining risk factor of hypertension morbidity were lifestyle and family history. From the study of 50 people which selected by sampling in Manggis district, we found that around 70% of sample population have a family history of hypertension. From the history of tobacco use, roughly 58% of sample population didnâ€™t take any tobacco at all. Also most of the people never drink any kind of alcohol which counted 52%.
KESIAPAN PETUGAS PUSKESMAS RENDANG DALAM MENGIMPLEMENTASIKAN PROGRAM JAMINAN KESEHATAN NASIONAL(JKN) KABUPATEN KARANGASEM BALI 2014
Authors: Putra Suryapranata Darma , Sutarsa Nyoman
Published: February 2017

Efforts to health insurance program for the community actually were pioneered by the government by some forms of social security in the health sector. In 2004, Issued the act no.40 about national social security system that regulates about the implementation of national health insurance (NHI) through a social insurance agent. The purpose of this research is to find readiness of primary health care officers rendang karangasem to implement it. Phenomenology design is used in descriptive qualitative research. Number of samples were 5 people, With the criteria of accuracy and validity of information obtained. This research were done for about 2 months, started from Februari until March 2014. Based on the result obtained discerned from the aspect of quality and quantity, from the perspective of puskesmas officers factors is considered sufficient human resources and infrastructure. Human resources is main pillars supporting areas and locomotion the organization. Good human resources, will become a strong pillars in implementing it. The building and an ambulance as infrastructure supporting the program implementation puskesmas and of these, is considered to be is quite sufficient from the perspective of puskesmas officers rendang.