bluuebunny/crossref_metadata_2025 huggingface dataset:
Hybrid Dark Channel Prior for Image Dehazing Based on Transmittance Estimation by Variant Genetic Algorithm
Authors: Wu Long , Chen Jie , Chen Shuyu , Yang Xu , Xu Lu , Zhang Yong , Zhang Jianlong
Published: April 2023

Image dehazing has always been one of the main areas of research in image processing. The traditional dark channel prior algorithm (DCP) has some shortcomings, such as incomplete fog removal and excessively dark images. In order to obtain haze-free images with high quality, a hybrid dark channel prior (HDCP) algorithm is proposed in this paper. HDCP first employs Retinex to remove the interference of the illumination component. The variant genetic algorithm (VGA) is then used to obtain the guidance image required by the guided filter to optimize the atmospheric transmittance. Finally, the modified dark channel prior algorithm is used to obtain the dehazed image. Compared with three other modified DCP algorithms, HDCP has the best subjective visual effects of haze removal and color fidelity. HDCP also shows superior objective indexes in the mean square error (MSE), peak signal-to-noise ratio (PSNR), structural similarity index (SSIM), and information entropy (E) for different haze degrees.
Unsteady Combustion of the Heptane-in-Water Emulsion Foamed with Hydrogen–Oxygen Mixture
Authors: Kiverin Alexey , Yakovenko Ivan
Published: April 2023

This research paper numerically studies how hydrocarbon additives affect hydrogen combustion in the process of complex fuel burning on the example of the combustible foam representing the heptane-in-water emulsion foamed with a hydrogen–oxygen mixture. It is demonstrated that the two-phase hydrodynamic model with an account of foam structure and chemical kinetics reproduces quite accurately, at least at the qualitative level, the experimentally observed features of foamed emulsion combustion. Due to this, it is concluded that a proposed model can be fruitfully used for the interpretation of the combustion features observed in such a complex combined fuel. Based on the obtained numerical data, it is found that there are two main possibilities related to the hydrogen–hydrocarbon chemistry interactions. In the case of near-stoichiometric, hydrocarbons act mainly as an inhibitor of hydrogen combustion; however, for lean hydrogen–oxygen mixtures, flame propagation is determined by the joint hydrocarbon and hydrogen oxidation kinetics. Herewith, the hydrocarbon burns together with the hydrogen inside the flame front in the case of slow combustion, while in the case of high-speed combustion, hydrogen oxidation kinetics becomes predominant, and hydrocarbons evaporate and burn behind the flame front, causing a lesser effect on the flame dynamics.
Apportionment of Chemical Components and Sources of PM2.5 in Shihezi City of Xinjiang, China
Authors: Zhong Yuting , He Youjiang , Li Xia , Li Shuting , Ayitken Maulen , Liu Xinchun
Published: April 2023

In order to reveal the pollution characteristics and sources of PM2.5, in this study, we collected PM2.5 filter membrane samples in Shihezi continuously from December 2020 to January 2021, and analyzed 10 kinds of water-soluble inorganic ions (WSIIs) and 24 inorganic elements (IEs), as well as organic carbon (OC) and elemental carbon (EC). The sources and transport paths of PM2.5 were also analyzed via PMF modeling and backward trajectory clustering analysis. The results show that, in winter, Shihezi can have a mean PM2.5 mass concentration as high as 164.69 ± 76.48 μg/m3, and the PM2.5 mass concentration on polluted days is 3.3 times that of clean days. Water-soluble inorganic ions (WSIIs), total carbon (TC), and inorganic elements (IEs) make up the percentage of PM2.5 mass concentration by 64.9%, 9.3%, and 2.6%, respectively. SO42−, NO3−, and NH4+ (SIAs) are the major WSIIs, accounting for 91.0% of the WSII concentration. The heavier the pollution, the more SIAs contribute to PM2.5. The OC mean mass concentration is 14.04 ± 5.32 μg/m3. As the winter pollution becomes worse and worse, the value of OC/PM2.5 decreases constantly while that of SOC/OC follows an opposite trend. During the process of heavy pollution in Shihezi, the secondary transformation of total carbon cannot be ignored. The positive definite matrix factorization (PMF) model result suggests that the main pollution origins of PM2.5 in Shihezi City comprise secondary sources, coal-burning sources, motor vehicle sources, industrial sources, and flying dust sources. The backward trajectory clustering analysis denotes that the winter pollution in Shihezi mainly comes from the local pollutants in Manas and the short-distance transport of pollutants from the Urumqi-Changji Region.
Molecular Mind Games: The Medicinal Action of Cyclodextrins in Neurodegenerative Diseases
Authors: Braga Susana Santos
Published: April 2023

Cyclodextrins are often used as molecular carriers for small active ingredients in medicine. Recently, the intrinsic medicinal activity of some of these compounds has been under investigation, mainly related to their ability to interfere with cholesterol and, therefore, prevent and treat cholesterol-related diseases such as cardiovascular disease and neuronal diseases arising from altered cholesterol and lipid metabolism. One of the most promising compounds within the cyclodextrin family is 2-hydroxypropyl-β-cyclodextrin (HPβCD), owing to its superior biocompatibility profile. This work presents the most recent advances in the research and clinical use of HPβCD against Niemann–Pick disease, a congenital condition involving cholesterol accumulation inside lysosomes in brain cells, Alzheimer’s and Parkinson’s. HPβCD plays a complex role in each of these ailments, going beyond the mere sequestering of cholesterol molecules and involving an overall regulation of protein expression that helps restore the normal functioning of the organism.
Effect of Fibre Orientation on the Bond Properties of Softwood and Hardwood Interfaces
Authors: Li Xin , Ashraf Mahmud , Kafle Bidur , Subhani Mahbube
Published: April 2023

Increasing concerns regarding carbon emissions and climate change are prompting a shift toward the use of sustainable materials in the construction industry. Engineered timber products are gaining attention in the construction industry due to advancements in lamination techniques and adhesives as well as the renewable characteristics of wood. Bond properties play a significant role in engineered timber products. In Australia, Radiata Pine (RP, softwood) and Shining Gum (SG, hardwood) share a large proportion of local and native plantation forest resources. The present paper investigates the bond behaviours of Australian softwoods (RP–RP), hardwoods (SG–SG) and hybrid-wood (RP–SG) combinations in both parallel (PAL) and perpendicular (PER) bonding directions using one-component polyurethane adhesives. The results indicate that most of the softwood samples were subjected to wood-side (timber) failure, whereas hardwood samples failed due to delamination but exhibited higher strength and stiffness regardless of bond direction. In contrast, bond direction had a significant effect on the bond characteristics of hybrid configurations. Improved bond properties were observed when bonded in PAL directions; however, negative effects were seen when bonded in PER directions. Obtained characteristic (5th percentile) shear bond strengths for RP–RP–PAL, RP–SG–PAL and SG–SG–PAL samples were 3.88 MPa, 6.19 MPa and 8.34 MPa, whilst those for RP–RP–PER, RP–SG–PER and SG–SG–PER samples were 3.45 MPa, 2.96 MPa and 7.83 MPa, respectively.
Methods to Account for Design for Disassembly: Status of the Building Sector
Authors: Lausselet Carine , Dahlstrøm Oddbjørn Andvik , Thyholt Marit , Eghbali Aida , Schneider-Marin Patricia
Published: April 2023

Embracing the design for disassembly (DfD) mindset when constructing new and renovating existing buildings is a promising means of achieving our climate targets and putting the circular economy principles in practice, as promoted in the European Green Deal. Current greenhouse gas emissions’ accounting frameworks only deal with DfD to a certain extent. A better and more common understanding of how this can be carried out will not only help promote DfD but also shed light on how DfD should be seen in the context of other emission reduction measures. This could help to achieve balanced and credible scenarios that can be used in policy-making processes. When building components or materials are used over several cycles (buildings), the allocation of environmental impacts across the different buildings must be discussed. In an attempt to address this issue, this study examined whether and how current LCA standards for construction products and buildings consider such allocation issues.
The Incidence and the Risk Factors for Pharyngocutaneous Fistula following Primary and Salvage Total Laryngectomy
Authors: Šifrer Robert , Strojan Primož , Tancer Ivana , Dolenc Maja , Fugina Simon , Zore Sara Bitenc , Aničin Aleksandar
Published: April 2023

The pharyngocutaneous fistula (PCF) is the most common complication following a total laryngectomy (TL) with a wide range of incidence and various potential risk factors. The aim was to analyse the incidence and potential risk factors for PCF formation in a large study set collected over a longer period of time. In the retrospective study at the Department of Otorhinolaryngology and Cervicofacial Surgery of Ljubljana, 422 patients who were treated for head and neck cancer by TL between 2007 and 2020 were included. The comprehensive clinicopathologic data were collected including potential risk factors related to the patient, disease, surgical treatment and post-operative period for the development of fistulae. The patients were categorized into a group with the fistula (a study group) and one without it (a control group). The PCF then developed in 23.9% of patients. The incidence following a primary TL was 20.8% and 32.7% following salvage TL (p = 0.012). The results demonstrated that surgical wound infection, piriform sinus invasion, salvage TL, and total radiation dose were determined as independent risk factors for PCF formation. A diminishing surgical wound infection rate would contribute to a further reduction of the PCF rate.
What’s Next after Hypomethylating Agents Failure in Myeloid Neoplasms? A Rational Approach
Authors: Awada Hussein , Gurnari Carmelo , Xie Zhuoer , Bewersdorf Jan Philipp , Zeidan Amer M.
Published: April 2023

Hypomethylating agents (HMA) such as azacitidine and decitabine are a mainstay in the current management of patients with myelodysplastic syndromes/neoplasms (MDS) and acute myeloid leukemia (AML) as either single agents or in multidrug combinations. Resistance to HMA is not uncommon, and it can result due to several tumor cellular adaptations. Several clinical and genomic factors have been identified as predictors of HMA resistance. However, the management of MDS/AML patients after the failure of HMA remains challenging in the absence of standardized guidelines. Indeed, this is an area of active research with several potential therapeutic agents currently under development, some of which have demonstrated therapeutic potential in early clinical trials, especially in cases with particular mutational characteristics. Here, we review the latest findings and give a rational approach for such a challenging scenario.
The Significance of SPP1 in Lung Cancers and Its Impact as a Marker for Protumor Tumor-Associated Macrophages
Authors: Matsubara Eri , Yano Hiromu , Pan Cheng , Komohara Yoshihiro , Fujiwara Yukio , Zhao Shukang , Shinchi Yusuke , Kurotaki Daisuke , Suzuki Makoto
Published: April 2023

Macrophages are a representative cell type in the tumor microenvironment. Macrophages that infiltrate the cancer microenvironment are referred to as tumor-associated macrophages (TAMs). TAMs exhibit protumor functions related to invasion, metastasis, and immunosuppression, and an increased density of TAMs is associated with a poor clinical course in many cancers. Phosphoprotein 1 (SPP1), also known as osteopontin, is a multifunctional secreted phosphorylated glycoprotein. Although SPP1 is produced in a variety of organs, at the cellular level, it is expressed on only a few cell types, such as osteoblasts, fibroblasts, macrophages, dendritic cells, lymphoid cells, and mononuclear cells. SPP1 is also expressed by cancer cells, and previous studies have demonstrated correlations between levels of circulating SPP1 and/or increased SPP1 expression on tumor cells and poor prognosis in many types of cancer. We recently revealed that SPP1 expression on TAMs is correlated with poor prognosis and chemoresistance in lung adenocarcinoma. In this review, we summarize the significance of TAMs in lung cancers and discuss the importance of SPP1 as a new marker for the protumor subpopulation of monocyte-derived TAMs in lung adenocarcinoma. Several studies have shown that the SPP1/CD44 axis contribute to cancer chemoresistance in solid cancers, so the SPP1/CD44 axis may represent one of the most critical mechanisms for cell-to-cell communication between cancer cells and TAMs.
PiFM and XPS Studies of Porous TiO2 Films for the Photocatalytic Decomposition of Polystyrene
Authors: Court-Wallace Christopher , Davies Philip R. , Davies-Jones Josh , Ososki Genevieve
Published: April 2023

The rate of photocatalytic oxidation of polystyrene over 0.1 wt% copper-doped TiO2 catalyst spin coated onto a flat substrate is investigated as a function of the catalyst deposition spin speed and, hence, film thickness. Photoinduced force microscopy and photoelectron spectroscopy show no evidence of any products of the photocatalytic oxidation remaining on the surface after reaction. The oxidation reaction shows no discernible dependence on spin speed; it is close to zero order in polystyrene concentration and exhibits a ½ life almost 50 times greater than the equivalent photocatalytic oxidation of stearic acid on the same catalysts. No difference between the rate of decay of the aliphatic and aromatic hydrogens of the polymer was observed, suggesting that once a polymer chain begins oxidising, subsequent steps are relatively rapid. This is consistent with the rate-determining step being dependent on the extent of coordination to the surface, which is much more favourable with stearic acid because of its carboxylic group.
The Multifaceted Role of Annexin A1 in Viral Infections
Authors: Resende Filipe , Araújo Simone de , Tavares Luciana Pádua , Teixeira Mauro Martins , Costa Vivian Vasconcelos
Published: April 2023

Dysregulated inflammatory responses are often correlated with disease severity during viral infections. Annexin A1 (AnxA1) is an endogenous pro-resolving protein that timely regulates inflammation by activating signaling pathways that culminate with the termination of response, clearance of pathogen and restoration of tissue homeostasis. Harnessing the pro-resolution actions of AnxA1 holds promise as a therapeutic strategy to control the severity of the clinical presentation of viral infections. In contrast, AnxA1 signaling might also be hijacked by viruses to promote pathogen survival and replication. Therefore, the role of AnxA1 during viral infections is complex and dynamic. In this review, we provide an in-depth view of the role of AnxA1 during viral infections, from pre-clinical to clinical studies. In addition, this review discusses the therapeutic potential for AnxA1 and AnxA1 mimetics in treating viral infections.
The Effects of Urea and Caprolactam on the Diffusion Behavior of Water in Polyvinyl Alcohol (PVA): A Molecular Dynamics Simulation Study
Authors: Ni Fei , Zhang Sen , Pan Yuefei , Xu Shubo , Zheng Wei , Hu Xinzhi
Published: April 2023

The effects of compound plasticizer urea/caprolactam (UC) on the diffusion behavior of water in mixtures with poly(vinyl alcohol) (PVA) were studied using a Molecular Dynamics (MD) simulation method. Five simulation models of PVA composites with different plasticizer contents were constructed to investigate the variation of the intermolecular interaction as well as the diffusion behavior of water molecules. Results showed that the predominant interaction between the functional groups of UC and PVA consisted of hydrogen bonds. As the plasticizer content increased, diffusion coefficients of water in PVA systems increased due to the comparably weak diffusion resistance. It was also found that the rotation of the PVA chains and the small molecules became faster with increasing UC content, and the relaxation time became shorter.
SmartWatcher©: A Solution to Automatically Assess the Smartness of Buildings
Authors: Ye Yu , Ramallo-González Alfonso P. , Tomat Valentina , Valverde Juan Sanchez , Skarmeta-Gómez Antonio
Published: April 2023

Buildings have now adopted a new dimension: the dimension of smartness. The rapid arrival of connected devices, together with the smart features that they provide, has allowed for the transition of existing buildings towards smart buildings. The assessment of the smartness of the large number of existing buildings could exhaust resources, but some organisations are requesting this regardless (such as the smart readiness indicator of the European Union). To tackle this issue, this work describes a tool that was created to find connected devices to automatically evaluate smartness. The tool, which was given the name SmartWatcher, uses a design-for-purpose natural language processing algorithm that converts verbal information into numerical information. The method was tested on real buildings in four different geographical locations. SmartWatcher is shown to be powerful, as it was capable of obtaining numerical values from verbal descriptions of devices. Additionally, a preliminary comparison of values obtained using the automatic engine and clipboard assessments showed that although the results were still far from being perfect, some visual correlation could be seen. This anticipates that, with the addition of appropriate techniques that refine this algorithm, or with the addition of new ones (with other more advanced natural language processing methods), the accuracy of this tool could be greatly increased.
Studies of Dislocations in Type Ib, Type IIa HPHT and CVD Single Crystal Diamonds
Authors: Misra Devi Shanker
Published: April 2023

In this review, the X-ray topography results of various types of single crystal diamonds (SCDs) are reported. Dislocations and dislocation bundles are present in all types of SCDs, the only exception being type IIa high-pressure, high-temperature (HPHT) SCDs. The technology of growing HPHT type IIa SCDs has advanced to a level where the samples show almost no dislocations or dislocation bundles. However, very few groups appear to have perfected the process of HPHT growth of type IIa SCDs. There appears to be a characteristic difference in the dislocations present in type Ib HPHT and chemical vapor deposited (CVD) SCDs. The dislocations in CVD SCDs are mostly in aggregate form, while in HPHT type Ib diamonds there are line dislocations which propagate in <111> or <112> directions. The CVD SCDs growth appears to be in the early stage in terms of the control of dislocations and dislocation bundles, compared to other semiconductor wafers. The dislocations and dislocation bundles and aggregates in SCDs limit their applications in electronic and optical devices. For instance, high-power laser windows must have low dislocations and dislocation bundles. For electronic devices such as high-power diodes, dislocations reduce the breakdown voltage of SCDs, limiting their applications. The knowledge of dislocations, their identification and their origin are, therefore, of utmost importance for the applications of SCDs, be they HPHT or CVD grown.
Novel Mononuclear Tetrabromonitrosylrhenate(II) Complexes Containing Azole-Type Ligands: Magnetostructural Characterization through Hirshfeld Surfaces Analysis
Authors: Pacheco Mario , González-Platas Javier , Kremer Carlos , Julve Miguel , Lloret Francesc , Cuevas Alicia
Published: April 2023

Our research group has made incursions into the scarcely known coordination chemistry of rhenium(II). The literature shows that Re(II) mononuclear complexes are attractive in molecular magnetism due to high magnetic anisotropy because of a significant spin-orbit coupling, making them a potential source for new molecule-based magnets. In this work, we present the preparation of four novel Re(II) compounds of general formula NBu4[Re(NO)Br4(L)] [NBu4+ = tetra-n-butylammonium: L = imidazole (1), pyrazole (2), 1,2,4-triazole (3) and 1H-tetrazole (4)]. The four compounds were fully characterized by single-crystal X-ray diffraction, infrared spectroscopy, and cryomagnetic measurements in the temperature range of 1.8–300 K. Their crystal structures consist of mononuclear [Re(NO)Br4(L)]− complex anions and NBu4+ cations. Each Re(II) ion is six-coordinate with a linear nitrosyl group and one monodentate nitrogen-donor (L), which are trans-positioned, plus four bromide groups, building a tetragonally distorted octahedral surrounding. The inter-anionic contacts were thoroughly analyzed using Hirshfeld surface analyses (plots over the dnorm, shape index, and 2D fingerprints). Cryomagnetic measurements show that these complexes behave as quasi-magnetically isolated spin doublets with weak antiferromagnetic interactions at low temperatures. The magnetic behavior of Re(II) was modeled by the influence of the ligand field, tetragonal distortion, spin-orbit coupling, and covalence effects. In addition, the antiferromagnetic exchange coupling was correlated to the nature of the intermolecular interactions.
Orientation Relationship of FeNiC and FeNiCSi from Variant Detection in EBSD Data
Authors: Seehaus Mattis , Pei Risheng , Korte-Kerzel Sandra , Sandlöbes-Haut Stefanie
Published: April 2023

The determination of orientation relationships in dual or multi-phase materials is very important in the field of interface engineering for the design of materials with tailored properties. In this work, a code is developed for the automated and statistical analysis of the orientation relationship of electron backscatter diffraction data. The code is applied to the example of Fe-Ni-(Si)-C alloys containing lenticular martensite and retained austenite, and it is shown that the orientation relationship (OR) corresponds to the Greninger–Troiano OR and that a statistically reliable investigation of the OR between the retained austenite and the related martensite variants is feasible using the code developed in this study.
Sorption of Alizarin Red S and Methylene Blue on Halloysite from Single and Mixed Solutions
Authors: Zhou Wenfang , Carlson Kristen , Wu Qingfeng , Wang Xisen , Xu Shangping , Li Zhaohui
Published: April 2023

The extensive use of synthetic materials in modern society presents a great challenge to environmental and water quality. As such, numerous studies were dedicated to the removal of emerging contaminants from water using novel materials as sorbents or catalysts. With large reserves and low material costs, Earth material has also attracted great attention for contaminant removal. Halloysite is a 1:1 layered clay mineral with moderate cation exchange capacity that can be used for the removal of cationic contaminants. On the other hand, as it may bear positive charges on the aluminum hydroxyl sheets, it could be used to remove anionic contaminants. In this study, the removal of a cationic dye, methylene blue (MB), and an anionic dye, alizarin red S (ARS), from the water was evaluated from single and mixed solutions. The results suggested that from single solutions, MB removal was via cation exchange while ARS removal could have originated from anion exchange. From mixed solutions, their removal was mutually increased, which may be due to a synergistic effect in the presence of a type of charged dyes serving as counterions to enhance the sorption of dyes of opposite charges. This finding suggests that halloysite may serve as a sorbent for the removal of organic contaminants of different charges at the same time, which is a new perspective that needs further evaluation and expansion.
Drug-Induced Acute Pancreatitis in Hospitalized COVID-19 Patients
Authors: Paramythiotis Daniel , Karlafti Eleni , Veroplidou Kalliopi , Fafouti Maria , Kaiafa Georgia , Netta Smaro , Michalopoulos Antonios , Savopoulos Christos
Published: April 2023

Coronavirus disease-19 (COVID-19), caused by SARS-CoV-2, is a systemic disease that affects not only the respiratory system, but also other systems, including gastrointestinal. A great number of different drugs have been used on hospitalized patients for the management of COVID-19, and acute pancreatitis (AP) has been reported as a complication or side effect of these drugs. The development of drug-induced acute pancreatitis (DIAP) follows a complex of pathophysiological mechanisms, and particular risk factors play a key role. Diagnosis of DIAP depends on specific criteria, and based on these, a drug may be characterized as having a definite, probable or possible connection with AP. The aim of this review is to present the medications that are used for COVID-19 management and are associated with AP in hospitalized patients. The list of these drugs mainly includes corticosteroids, glucocorticoids, non-steroidal anti-inflammatory drugs (NSAIDs), antiviral agents, antibiotics, monoclonal antibodies, estrogens and anesthetic agents. Moreover, the prevention of the development of DIAP is vital, especially for critically ill patients who may receive multiple drugs. DIAP management is mainly non-invasive and the first step concerns the exception of the suspicious drug from patients therapy.
Gišogenetic Variation in White-Spruce (Picea glauca (Moench) Voss) Trees of Yukon Beringia, Canada
Authors: Savidge Rodney Arthur , Yuan Xin , Foerster Hartmut
Published: April 2023

Gišogenesis, otherwise known as secondary-xylem development, was investigated in an old-growth upland population of white spruce (Picea glauca (Moench) Voss) trees having morphologically diverse crowns and growing on a south slope north of East Fork Creek bordering never-glaciated Yukon Beringia. After tree felling, trunks were segmented into one-metre lengths. In the laboratory, widths of xylem layers were measured across the four cardinal directions at each height, followed by Pearson’s product momentum correlations to evaluate variation in historical gišogenetic vigour within and between trees. Substantial variation was found, and it cannot readily be explained in terms of differences in extrinsic environment. Physiological differences in intrinsic gišogenetic regulation within a genetically diverse population, comprising both refugia and recent recruits, is proposed as a probable explanation, thus emphasizing the individuality of each tree’s internal control over how it responds to the extrinsic environment. Further investigations within Yukon Beringia may yield insight into evolutionary diversification of gišogenesis.
Special Issue “DNA Replication/Repair, and the DNA Damage Response in Human Disease”
Authors: Zhang Dong , Eckert Kristin A. , Lee Marietta Y. W. T.
Published: April 2023

Mutations of numerous genes involved in DNA replication, DNA repair, and DNA damage response (DDR) pathways lead to a variety of human diseases, including aging and cancer [...]
Molecular and Sociodemographic Colorectal Cancer Disparities in Latinos Living in Puerto Rico
Authors: Perez-Mayoral Julyann , Gonzalez-Pons Maria , Centeno-Girona Hilmaris , Montes-Rodríguez Ingrid M. , Soto-Salgado Marievelisse , Suárez Belisa , Rodríguez Natalia , Colón Giancarlo , Sevilla Javier , Jorge Daphne , Llor Xavier , Xicola Rosa M. , Toro Doris H. , Tous-López Luis , Torres-Torres Marla , Reyes José S. , López-Acevedo Nicolas , Goel Ajay , Rodríguez-Quilichini Segundo , Cruz-Correa Marcia
Published: April 2023

Background: The incidence of sporadic colorectal cancer (CRC) among individuals <50 years (early-onset CRC) has been increasing in the United States (U.S.) and Puerto Rico. CRC is currently the leading cause of cancer death among Hispanic men and women living in Puerto Rico (PRH). The objective of this study was to characterize the molecular markers and clinicopathologic features of colorectal tumors from PRH to better understand the molecular pathways leading to CRC in this Hispanic subpopulation. Methods: Microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and KRAS and BRAF mutation status were analyzed. Sociodemographic and clinicopathological characteristics were evaluated using Chi-squared and Fisher’s exact tests. Results: Of the 718 tumors analyzed, 34.2% (n = 245) were early-onset CRC, and 51.7% were males. Among the tumors with molecular data available (n = 192), 3.2% had MSI, 9.7% had BRAF, and 31.9% had KRAS mutations. The most common KRAS mutations observed were G12D (26.6%) and G13D (20.0%); G12C was present in 4.4% of tumors. A higher percentage of Amerindian admixture was significantly associated with early-onset CRC. Conclusions: The differences observed in the prevalence of the molecular markers among PRH tumors compared to other racial/ethnic groups suggest a distinct molecular carcinogenic pathway among Hispanics. Additional studies are warranted.
A Pilot Study of the Effects of Individualized Home Dual Task Training by Mobile Health Technology in People with Dementia
Authors: Villamil-Cabello Eduardo , Meneses-Domínguez Mercedes , Fernández-Rodríguez Ángela , Ontoria-Álvarez Patricia , Jiménez-Gutiérrez Alfonso , Fernández-del-Olmo Miguel
Published: April 2023

The objective of this pilot study was to evaluate the effects of dual-task training implemented by mobile health technology on performance on motor and dual-task tests in subjects with dementia. Nineteen subjects with a medical diagnosis of dementia were assigned to an experimental group (EG, n = 12) or control group (CG, n = 7). The EG participated in 24 sessions (3/week) of a homebase dual-task exercises program, in addition to their ongoing cognitive and physiotherapy treatment. The training program was implemented individually in the patient’s home by caregivers or relatives through electronic devices controlled by a mobile application. Before (Pre) and after (Post) the program, performance on motor and motor/cognitive (dual-task) tests were evaluated. Motor evaluation included gait at preferred and maximal speed, the Up and Go, and the Handgrip Strength test. Dual-task tests included gait with subtraction 3 s from 100 and naming animals (verbal fluency). The CG only performed the evaluations in addition to their cognitive and physiotherapy treatment. The statistical analysis (ANOVA Group*Test) showed a statically significant improvement for both dual-task tests in the EG after the training program, while the CG showed an impairment in the verbal fluency test. Conclusion: the implementation of a home exercise program carried out with mobile technology in people with dementia is feasible and positively affects their performance on dual tasks.
Barriers and Facilitators to Psychologists’ Telepsychology Uptake during the Beginning of the COVID-19 Pandemic
Authors: Watson Jack D. , Pierce Bradford S. , Tyler Carmen M. , Donovan Emily K. , Merced Kritzia , Mallon Margaret , Autler Aaron , Perrin Paul B.
Published: April 2023

The COVID-19 pandemic transformed the delivery of psychological services as many psychologists adopted telepsychology for the first time or dramatically increased their use of it. The current study examined qualitative and quantitative data provided by 2619 practicing psychologists to identify variables facilitating and impeding the adoption of telepsychology in the U.S. at the beginning of the COVID-19 pandemic. The top five reported barriers were: inadequate access to technology, diminished therapeutic alliance, technological issues, diminished quality of delivered care or effectiveness, and privacy concerns. The top five reported facilitators were: increased safety, better access to patient care, patient demand, efficient use of time, and adequate technology for telepsychology use. Psychologists’ demographic and practice characteristics robustly predicted their endorsement of telepsychology barriers and facilitators. These findings provide important context into the implementation of telepsychology at the beginning of the pandemic and may serve future implementation strategies in clinics and healthcare organizations attempting to increase telepsychology utilization.
Nutrient Adequacy in Endurance Athletes
Authors: Moss Kamiah , Kreutzer Andreas , Graybeal Austin J. , Zhang Yan , Braun-Trocchio Robyn , Porter Ryan R. , Shah Meena
Published: April 2023

Proper nutrition is critical for optimal performance in endurance athletes. However, it is unclear if endurance athletes are meeting all their energy and nutrient needs. We examined if endurance athletes are meeting their nutritional requirements and if this differed by sex. Ninety-five endurance athletes (n = 95; 50.5% men; 34.9 ± 12.9 y) participated in the study. Dietary intake was evaluated using the 24 h dietary recall method. Energy and nutrient intakes were calculated using the ESHA Food Processor Diet Analysis Software and compared against reference nutrient intakes. Endurance athletes did not consume the recommended amount of energy (76.8% of athletes), carbohydrates (95.8%), linoleic acid (75.8%), α-linolenic acid (ALA) (77.9%), eicosatetraenoic and docosahexaenoic acid (96.8%), dietary fiber (49.5%), vitamins D (93.7%), E (71.6%), and K (54.7%), folate (54.7%), pantothenic acid (70.5%), biotin (83.2%), manganese (58.9%), magnesium (56.8%), chromium (91.6%), molybdenum (93.7%), choline (85.3%), and potassium (56.8%), and consumed too much saturated fat (50.5%) and sodium (94.7%) than recommended. Fisher’s Exact test showed that the requirements for dietary fiber (70.8% vs. 27.7%), ALA (87.5% vs. 68.1%), and total water (70.8% vs. 44.7%) were not met by more men versus women (p < 0.05). The needs for protein (70.2% vs. 25%) and vitamin B12 (46.8% vs. 22.9%) were not met by more women compared to men (p < 0.05). These findings need to be confirmed by a larger study.
Challenges and Suggestions in the Management of Stomach and Colorectal Cancer in Uzbekistan: The Third Report of the Uzbekistan–Korea Oncology Consortium
Authors: Rim Chai Hong , Lee Won Jae , Akhmedov Odiljon , Sabirov Ulugbek , Ten Yakov , Ziyayev Yakhyo , Tillyashaykhov Mirzagaleb , Rim Jae Suk
Published: April 2023

In general, as the national standard of living and life expectancy of people increase, the health burden of cancer also increases. Prevention strategies, including the screening and investigation of the causes of cancer as well as the expansion of treatment infrastructure, are necessary. In this review, we discussed the management strategies for gastric and colorectal cancers in Uzbekistan. Gastrointestinal cancers can be significantly prevented by certain screening strategies such as endoscopic examination. Furthermore, as both cancer types are closely related to the eating habits and lifestyles of people in Uzbekistan, such causes should be investigated and prevented. Practical advice to increase the efficiency of treatment is included, considering the current situation in Uzbekistan. Data from South Korea, which has performed nationwide screening for two decades and has made progress in improving the prognosis of patients with gastrointestinal cancers, will be discussed as a literature control.
A Scoping Review of Theoretical Lenses and Methodological Approaches in Indigenous Women’s Health and Well-Being Research in North America over the Past Two Decades
Authors: McGuire-Adams Tricia , Gaudet Janice Cindy , Loukes Keira A. , Ferreira Celeste
Published: April 2023

Theoretical approaches influence research design, engagement, and outcomes. The relevance of critical theoretical and methodological approaches to Indigenous women’s health and well-being research has increased in the last decade. It is difficult to assess the ways in which theoretical lenses can effectively interrupt and challenge systemic erasure, ongoing harms, and deficit-based (ill-health-centered) approaches to Indigenous women’s health and well-being, a fact that is not broadly acknowledged. We conducted a scoping review to (a) map the type and frequency of critical theoretical lenses used by researchers focused on Indigenous women’s health and well-being in North America over the past two decades and (b) identify which topics tend to use which theoretical lens. We have conducted a scoping review to examine peer-reviewed articles from eight electronic databases. In the articles selected over 2000–2021, we found an increase in the use of community-based participatory research, decolonial lenses, and feminist lenses. Over the last decade, there has been a decrease in quantitative social science approaches. While a range of critical theoretical and methodological approaches are increasingly being applied, the use of cultural resurgence and Indigenous feminism in health research is not widespread.
The Integration of Patient-Centered Care and the Biopsychosocial Model by Athletic Trainers in the Secondary School Setting
Authors: Mendoza Adriana M. , Drescher Matthew J. , Eberman Lindsey E.
Published: April 2023

Our purpose was to explore the degree to which secondary school athletic trainers (SSATs) perceive they are integrating the principles of patient-centered care (PCC) and the biopsychosocial (BPS) model in their practice. We used a cross-sectional design to explore the primary research question. We used the Global Perceptions of Athletic Trainer Patient-Centered Care (GPATPCC) tool and the Biopsychosocial Model of Health (BPSMH) tool, both measured on a 4-point Likert scale (1 = strongly disagree, 2 = disagree, 3 = agree, 4 = strongly agree, with an unscored “unsure” option). We sent the survey to 5665 SSATs through the National Athletic Trainers’ Association. Results indicate participants expressed strong agreement (mode = 4) with 7 of the 14 statements and agreement (mode = 3) with the remaining 7 statements of the GPATPCC tool (grand mean = 3.4 ± 0.8). Overall, participants rated their level of agreement on the BPSMH as agreeing (mode = 3) for each item (grand mean = 3.0 ± 1.0). SSATs perceive they are integrating the principles of PCC and the BPS model in clinical practice. These findings align with two previous studies concluding that patients, parents, and providers believe athletic trainers provide care that is focused on whole-person healthcare.
Molecular Research on Mental Disorders
Authors: Sowa-Kućma Magdalena , Stachowicz Katarzyna
Published: April 2023

Mental disorders and substance use disorders affect approximately 13% of the world’s population [...]
Application of Artificial Intelligence in the Diagnosis, Treatment, and Prognostic Evaluation of Mediastinal Malignant Tumors
Authors: Pang Jiyun , Xiu Weigang , Ma Xuelei
Published: April 2023

Artificial intelligence (AI), also known as machine intelligence, is widely utilized in the medical field, promoting medical advances. Malignant tumors are the critical focus of medical research and improvement of clinical diagnosis and treatment. Mediastinal malignancy is an important tumor that attracts increasing attention today due to the difficulties in treatment. Combined with artificial intelligence, challenges from drug discovery to survival improvement are constantly being overcome. This article reviews the progress of the use of AI in the diagnosis, treatment, and prognostic prospects of mediastinal malignant tumors based on current literature findings.
Physical Activity Patterns, Circadian Rhythms, and Aggressive and Suicidal Behavior among a Larger Sample of the General Population Aged 15 to 34 Years
Authors: Khazaie Habibolah , Najafi Farid , Chehri Azita , Rahimi-Movaghar Afarin , Amin-Esmaeili Masoumeh , Moradinazar Mahdi , Zakiei Ali , Pasdar Yahya , Brühl Annette Beatrix , Brand Serge , Sadeghi-Bahmani Dena
Published: April 2023

Background: From a psychological perspective, aggressive behavior, non-suicidal self-injury and suicidal behavior could be considered dysfunctional coping strategies. Poor sleep patterns may further increase such dysfunctional coping. In contrast, regular physical activity may have the power to counteract such dysfunctional coping. Given this background, the aim of the present study was to combine categories of circadian rhythms as a proxy of normative sleep patterns and categories of physical activity patterns, and to associate these categories with aggressive behavior, non-suicidal self-injury and suicidal behavior among a larger sample of adolescents and young adults, aged 15 to 34 years. Method: A total of 2991 (55.6% females) individuals aged 15 to 34 years of the so-called Ravansar non-communicable disease cohort study (RaNCD) took part in this study. Participants completed self-rating questionnaires covering circadian-related sleep patterns, regular physical activity, socio-demographic information and dimensions of aggression, non-suicidal self-injury and suicidal behavior. Results: In a first step, both sleep patterns (circadian rhythm disorder: yes vs. no) and physical activity patterns (high vs. low) were dichotomized. Next, participants were assigned to one of four prototypical clusters: No circadian sleep disorders and high physical activity (“Hi-Sleep-Hi-PA”); no circadian sleep disorders and low physical activity (“Hi-Sleep-Lo-PA”); circadian sleep disorders and high physical activity (“Lo-Sleep-Hi-PA”); circadian sleep disorders and low physical activity (“Lo-Sleep-Lo-PA”). Projecting these four clusters on dimensions of aggressive behavior, non-suicidal self-injury and suicidal behavior, the following findings were observed: Participants of the “Hi-Sleep-Hi-PA” reported the lowest scores for aggressive behavior, self-injury and suicidal behavior, compared to participants of the “Lo-Sleep-Lo-PA” cluster. No differences for aggressive behavior, self-injury and suicidal behavior were observed among participants of the “Hi-Sleep-Lo-PA” and the “Lo-Sleep-Hi-PA” clusters. Conclusions: It appeared that the combination of favorable circadian sleep patterns and high physical activity patterns was associated with lower aggressive behavior, lower self-injury and suicidal behavior as proxies of favorable psychological functioning. In contrast, persons reporting high circadian sleep disorders and low physical activity patterns appeared to demand particular attention and counseling for both their lifestyle issues (sleep and physical activity) and their dysfunctional coping strategies.
Impact of Two Types of Exercise Interventions on Leptin and Omentin Concentrations and Indicators of Lipid and Carbohydrate Metabolism in Males with Metabolic Syndrome
Authors: Makiel Karol , Suder Agnieszka , Targosz Aneta , Maciejczyk Marcin , Kozioł-Kozakowska Agnieszka , Haim Alon
Published: April 2023

Leptin (LEP) and omentin (OMEN) are proteins whose concentrations change with the development of the metabolic syndrome (MetS). There are few intervention studies using various forms of physical activity in people with MetS that aim to determine the impact of physical exercise on the fluctuations of the presented hormones, and their results are contradictory. The present study aimed to examine the effect of two types of exercise intervention on LEP and OMEN concentrations and indicators of lipid and carbohydrate metabolism in males with MetS. The study included 62 males with MetS (age 36.6 ± 6.9 years, body mass 110.31 ± 17.37 kg), randomly allocated to EG1, the examined group with aerobic training (n = 21); EG2, the examined group with combined aerobic and resistance training (n = 21), both for 12 weeks, and the control group (CG) without interventions (n = 20). Anthropometric measurements, body composition (body fat [BF], android body fat [ANDR]), as well as a biochemical blood analysis (omentin [OMEN], leptin [LEP], quantitative insulin sensitivity check index [QUICKI], high-density lipoprotein cholesterol [HDL-C] and nonHDL-C) were performed at baseline, and at 6 and 12 weeks of interventions and after 4 weeks after ending intervention (follow-up). Intergroup and intragroup comparisons were performed. In the intervention groups EG1 and EG2, a decrease in BF was observed as well as an improvement in carbohydrate metabolism parameters. In the EG1 group, the level of ANDR was reduced. In EG2 a decrease in LEP concentration between measurements was confirmed. However, no significant changes were found in the concentration of OMEN in any groups. Combined aerobic and resistance exercises led to a higher reduction of LEP concentration than applying only aerobic training in males with MetS.
Effect of Intracoronal Sealing Biomaterials on the Histological Outcome of Endodontic Revitalisation in Immature Sheep Teeth—A Pilot Study
Authors: Rathinam Elanagai , Rajasekharan Sivaprakash , Declercq Heidi , Vanhove Christian , De Coster Peter , Martens Luc
Published: April 2023

The influence of intracoronal sealing biomaterials on the newly formed regenerative tissue after endodontic revitalisation therapy remains unexplored. The objective of this study was to compare the gene expression profiles of two different tricalcium silicate-based biomaterials alongside the histological outcomes of endodontic revitalisation therapy in immature sheep teeth. The messenger RNA expression of TGF-β, BMP2, BGLAP, VEGFA, WNT5A, MMP1, TNF-α and SMAD6 was evaluated after 1 day with qRT-PCR. For evaluation of histological outcomes, revitalisation therapy was performed using Biodentine (n = 4) or ProRoot white mineral trioxide aggregate (WMTA) (n = 4) in immature sheep according to the European Society of Endodontology position statement. After 6 months’ follow-up, one tooth in the Biodentine group was lost to avulsion. Histologically, extent of inflammation, presence or absence of tissue with cellularity and vascularity inside the pulp space, area of tissue with cellularity and vascularity, length of odontoblast lining attached to the dentinal wall, number and area of blood vessels and area of empty root canal space were measured by two independent investigators. All continuous data were subjected to statistical analysis using Wilcoxon matched-pairs signed rank test at a significance level of p < 0.05. Biodentine and ProRoot WMTA upregulated the genes responsible for odontoblast differentiation, mineralisation and angiogenesis. Biodentine induced the formation of a significantly larger area of neoformed tissue with cellularity, vascularity and increased length of odontoblast lining attached to the dentinal walls compared to ProRoot WMTA (p < 0.05), but future studies with larger sample size and adequate power as estimated by the results of this pilot study would confirm the effect of intracoronal sealing biomaterials on the histological outcome of endodontic revitalisation.
Pharmacokinetic Evaluation of Tacrolimus in Chinese Adult Patients during the Early Stages Post-Lung Transplantation
Authors: Cui Yi-Fan , Pan Yan , Zhu Min-Fang , Jiao Zheng
Published: April 2023

Background: Although tacrolimus has been widely used in patients undergoing lung transplantation, few studies have reported the pharmacokinetics of tacrolimus in Chinese patients after lung transplantation. Thus, we aimed to investigate the pharmacokinetics and influential factors in this patient cohort in the early stage after lung transplantation. Methods: We enrolled 14 adult lung transplant recipients who were treated with tacrolimus and then intensively collected blood samples within a 12-h dosing interval. The pharmacokinetic parameters of tacrolimus were calculated using non-compartmental analysis, and the influence of pathophysiological characteristics and CYP3A5*3 and CYP3A4*1G genotypes on the pharmacokinetics of tacrolimus was assessed. Using linear regression analysis, we investigated the correlation between tacrolimus concentration at different sampling points and measured the area under the time-concentration curve (AUC0–12h). Results: Geometric mean of apparent clearance (CL/F) was 18.13 ± 1.65 L/h in non-CYP3A5*3/*3 carriers, five times higher than that in CYP3A5*3/*3 carriers (p < 0.001). Furthermore, the tacrolimus concentration 4 h after administration had the strongest correlation with AUC0–12h (R2 = 0.979). Conclusion: The pharmacokinetics of tacrolimus varied largely between patients during the early stage post-transplantation, which could be partially explained by CYP3A5*3 genetic polymorphisms.