bluuebunny/crossref_metadata_2025 huggingface dataset:
The regulatory role of metabolic organ-secreted factors in the nonalcoholic fatty liver disease and cardiovascular disease
Authors: Qin Li , Wu Junru , Sun Xuejing , Huang Xuewei , Huang Wei , Weng Chunyan , Cai Jingjing
Published: April 2023

Nonalcoholic fatty liver disease (NAFLD) is a chronic metabolic disease characterized by an excessive accumulation of fat in the liver, which is becoming a major global health problem, affecting about a quarter of the population. In the past decade, mounting studies have found that 25%–40% of NAFLD patients have cardiovascular disease (CVD), and CVD is one of the leading causes of death in these subjects. However, it has not attracted enough awareness and emphasis from clinicians, and the underlying mechanisms of CVD in NAFLD patients remain unclear. Available research reveals that inflammation, insulin resistance, oxidative stress, and glucose and lipid metabolism disorders play indispensable roles in the pathogenesis of CVD in NAFLD. Notably, emerging evidence indicates that metabolic organ-secreted factors, including hepatokines, adipokines, cytokines, extracellular vesicles, and gut-derived factors, are also involved in the occurrence and development of metabolic disease and CVD. Nevertheless, few studies have focused on the role of metabolic organ-secreted factors in NAFLD and CVD. Therefore, in this review, we summarize the relationship between metabolic organ-secreted factors and NAFLD as well as CVD, which is beneficial for clinicians to comprehensive and detailed understanding of the association between both diseases and strengthen management to improve adverse cardiovascular prognosis and survival.
High density lipoprotein-associated proteins in non-obese women with and without polycystic ovary syndrome
Authors: Butler Alexandra E. , Moin Abu Saleh Md , Reiner Željko , Sathyapalan Thozhukat , Jamialahmadi Tannaz , Sahebkar Amirhossein , Atkin Stephen L.
Published: April 2023

Introduction

Dyslipidemia frequently occurs in women with polycystic ovary syndrome (PCOS), but it is unclear whether dyslipidemia is due to obesity and insulin resistance (IR) or is inherent to PCOS. To address this, proteomic analysis of proteins important in lipid metabolism, particularly for high-density lipoprotein cholesterol (HDL-C), was performed in non-obese, non-insulin resistant PCOS women compared to matched controls.

Methods

Weight and aged-matched non-obese subjects with PCOS (n=24) and without IR were compared with control women (n=24). 19 proteins were measured by Somalogic proteomic analysis: alpha-1-antichymotrypsin, alpha-1-antitrypsin, apolipoproteins A-1, B, D, E, E2, E3, E4, L1, M, clusterin, complement C3, hemopexin, heparin cofactor-II (HCFII), kininogen-1, serum amyloid A-1, amyloid beta A-4 and paraoxonase-1.

Results

Women with PCOS had a higher free androgen index (FAI) (p<0.001) and anti-Mullerian hormone (AMH) (p<0.001), but IR and C-reactive protein (CRP), a marker of inflammation, did not differ from controls (p>0.05). The triglyceride:HDL-cholesterol ratio was elevated (p=0.03) in PCOS. Alpha-1-antitrypsin levels were lower (p<0.05) and complement C3 levels were higher (p=0.001) in PCOS. C3 correlated with body mass index (BMI) (r=0.59, p=0.001), IR (r=0.63, p=0.0005) and CRP (r=0.42, p=0.04) in women with PCOS, though no correlations of these parameters with alpha-1-antitrypsin were found. Total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol and levels of the other 17 lipoprotein metabolism-associated proteins did not differ between the two groups (p>0.05). However, in PCOS, alpha-1-antichymotrypsin correlated negatively with BMI (r=-0.40, p<0.04) and HOMA-IR (r=-0.42, p<0.03), apoM correlated positively with CRP (r=0.36, p<0.04) and HCFII correlated negatively with BMI (r=-0.34, p<0.04).

Conclusion

In PCOS subjects, when obesity, IR and inflammation confounders were absent, alpha-1-antitrypsin was lower and complement C3 was higher than in non-PCOS women, suggesting increased cardiovascular risk; however, subsequent obesity related IR/inflammation likely stimulates other HDL-associated protein abnormalities, thus increasing cardiovascular risk further.
Design of triple cogeneration system for hydrogen fuel cell in greenhouse based on resource analysis
Authors: Yang Jinlong , Li Rui , Lee Chul-Hee
Published: April 2023

Introduction: Hydrogen energy has a massive advantage in the energy supply mode regarding greenhouse gas emissions. Nevertheless, the energy supply system needs to be redesigned to meet the heating/cooling needs and the goals of using hydrogen energy.

Methods: The comprehensive utilization efficiency of system energy can be improved using resource analysis to solve the problem of waste heat and formulate a technical plan for triple cogeneration of hydrogen greenhouse.

Results: By calculation, the energy efficiency of the coal boiler heating system, the hydrogen energy heating system and the hydrogen greenhouse triple heating system are 65%, 52.93%, and 73.36%, respectively. Compared to the coal boiler heating system and the hydrogen energy heating system, the advantages of the hydrogen greenhouse triple cogeneration system are that the comprehensive utilization efficiency of the system energy has been improved, and no CO2 is generated when it works, which does not cause pressure on environmental protection. At the same time, the exergy efficiency of the hydrogen greenhouse triple cogeneration system is higher. Currently, due to the high price of hydrogen and fuel cells, the economic advantages are not outstanding. Still, coal energy is expected to be replaced in the future with the continuous decline in the cost of hydrogen and fuel cells. According to the current coal price, when the hydrogen price decreases to below $1.3/kg, coal will lose its price advantage in terms of fuel. At the same time, hydrogen has a high energy density, small volume, and low transportation cost. According to IRENA and Hydrogen Council, the cost of producing hydrogen from renewable energy will drop to $1/kg by 2050. The system will significantly reduce the operating costs of greenhouses in the future.

Discussion: As a result, the hydrogen greenhouse triple cogeneration system is suitable for producing greenhouse agriculture and the heating method of fossil fuel combustion that will replace coal in the future.
Investigating the effectiveness of livelihood capital in reducing re-poverty risk: an empirical analysis of policy withdrawal and income structures in rural China
Authors: Fan Yipin , Ning Jing , Qin Hong
Published: April 2023

In the context of China’s comprehensive poverty alleviation efforts, this study explores the differences in the re-poverty risk between households that have been lifted out of poverty before and after policy withdrawal, as well as the sensitivity of different family types to their livelihood capital. The study used data from 45,141 out-of-poverty households in Yucheng County, Henan Province, from 2016 to 2020, and combined the poverty vulnerability theory and short-fall risk method to evaluate the re-poverty risk. The Tobit model was used to explore the influence of livelihood capital on the re-poverty risk. The study found that the overall re-poverty risk is 1.13%, which increases to 18.09% after direct poverty alleviation policy is withdrawn. The risk of working families is significantly lower than farming families. All kinds of livelihood capital significantly reduce the re-poverty risk, with natural capital playing the most significant role. For different family types, the marginal contribution of financial capital to reducing the re-poverty risk is relatively larger in working households, while that of natural capital is larger in farming households. Specifically, labor capacity, arable land area, local leaders, and loans have a more significant inhibitory effect on the re-poverty risk. These findings provide valuable insights for formulating policies related to increasing household income and preventing the occurrence of re-poverty.
South Africa’s initiative toward an integrated biodiversity data portal
Authors: Daly Brenda , Ranwashe Fhatani
Published: April 2023

Researchers and policymakers have called on the South African National Biodiversity Institute (SANBI), in its role as the statutory biodiversity organisation of South Africa, to develop a coordinated and integrated biodiversity informatics hub. While biodiversity information is increasingly available from several providers, there is no platform through which to access comprehensive biodiversity information from a single source. In response, SANBI is redeveloping the Biodiversity Advisor platform, which will integrate geospatial, species and ecosystem data, literature and other data made available by a wide variety of data partners. To do so it has adopted a Service Orientated Architecture, whereby existing, independent biodiversity datasets are integrated. Consolidating such an extensive and varied set of databases, however, introduces some significant operational challenges. Solutions had to be found to address limited infrastructure, the complexity of the system, the lack of taxonomic identifiers, as well as the need for access and attribution. Solutions had to be pragmatic, given limited financial resources and limited capacity for information technology. The emerging outcome is a system that will easily allow users to access most biodiversity data within South Africa from a single, recognised platform.
Cellular immunity in COVID-19 and other infections in Common variable immunodeficiency
Authors: Løken Ragnhild Øye , Fevang Børre
Published: April 2023

COVID-19 has shed light on the role of cellular immunity in the absence of humoral response in different patient groups. Common variable immunodeficiency (CVID) is characterized by impaired humoral immunity but also an underlying T-cell dysregulation. The impact of T-cell dysregulation on cellular immunity in CVID is not clear, and this review summarizes available literature on cellular immunity in CVID with a particular focus on COVID-19. Overall mortality of COVID-19 in CVID is difficult to assess, but seems not significantly elevated, and risk factors for severe disease mirrors that of the general population, including lymphopenia. Most CVID patients have a significant T-cell response to COVID-19 disease with possible cross-reactivity to endemic coronaviruses. Several studies find a significant but impaired cellular response to basal COVID-19 mRNA vaccination that is independent of an antibody response. CVID patients with infection only have better cellular responses to vaccine in one study, but there is no clear association to T-cell dysregulation. Cellular response wane over time but responds to a third booster dose of vaccine. Opportunistic infection as a sign of impaired cellular immunity in CVID is rare but is related to the definition of the disease. CVID patients have a cellular response to influenza vaccine that in most studies is comparable to healthy controls, and annual vaccination against seasonal influenza should be recommended. More research is required to clarify the effect of vaccines in CVID with the most immediate issue being when to booster the COVID-19 vaccine.
A novel prognostic signatures based on metastasis- and immune-related gene pairs for colorectal cancer
Authors: Pan Bei , Yue Yanzhe , Ding Wenbo , Sun Li , Xu Mu , Wang Shukui
Published: April 2023

Background

Metastasis remains the leading cause of mortality in patients diagnosed with colorectal cancer (CRC). The pivotal contribution of the immune microenvironment in the initiation and progression of CRC metastasis has gained significant attention.

Methods

A total of 453 CRC patients from The Cancer Genome Atlas (TCGA) were included as the training set, and GSE39582, GSE17536, GSE29621, GSE71187 were included as the validation set. The single-sample gene set enrichment analysis (ssGSEA) was performed to assess the immune infiltration of patients. Least absolute shrinkage and selection operator (LASSO) regression analysis, Time-dependent receiver operating characteristic (ROC) and Kaplan-Meier analysis were used to construct and validate risk models based on R package. CTSW and FABP4-knockout CRC cells were constructed via CRISPR-Cas9 system. Western-blot and Transwell assay were utilized to explore the role of fatty acid binding protein 4 (FABP4) / cathepsin W (CTSW) in CRC metastasis and immunity.

Results

Based on the normal/tumor, high-/low-immune cell infiltration, and metastatic/non-metastatic group, we identified 161 differentially expressed genes. After random assignment and LASSO regression analysis, a prognostic model containing 3 metastasis- and immune-related gene pairs was constructed and represented good prognostic prediction efficiency in the training set and 4 independent CRC cohorts. According to this model, we clustered patients and found that the high-risk group was associated with stage, T and M stage. In addition, the high-risk group also shown higher immune infiltration and high sensitivity to PARP inhibitors. Further, FABP4 and CTSW derived from the constitutive model were identified to be involved in metastasis and immunity of CRC.

Conclusion

In conclusion, a validated prognosis predictive model for CRC was constructed. CTSW and FABP4 are potential targets for CRC treatment.
Deep genetic divergences and geographic distribution of the red algal genus Caulacanthus (Gigartinales)
Authors: Yang Mi Yeon , Kim Myung Sook
Published: April 2023

An increasing number of studies have demonstrated that genetic differentiation and cryptic diversity in the sea occur over considerably smaller spatial scales than previously comprehended, considering the wide distribution range of many morphologically defined macroalgal species. However, knowledge of the turf-forming red algaCaulacanthusis incomplete regarding its species diversity, as well as genetic differentiation within the genus. We analyzedCaulacanthusspecimens from the NW Pacific, NE Pacific, Central Pacific, SW Pacific, SE Indian, NE Atlantic, and SE Atlantic Ocean using mitochondrial cytochrome oxidase subunit I (COI-5P), plastid ribulose-1,5-bisphosphate carboxylase/oxygenase (rbcL), and Rubisco spacer (rbcL-S). The objectives of this study were to 1) determine the number of species that exhibit the morphology ofC. ustulatus, 2) investigate the present distribution pattern ofCaulacanthusspecies, and 3) estimate the degree of genetic connectivity between the populations ofCaulacanthusspecies from different regions. Our results revealed molecular evidence that the genusCaulacanthuscomprises of at least seven species with deep genetic divergence, which is indicative of not only a strong geographical subdivision but also a relatively long temporal discontinuity. Most species exhibited limited geographic distribution, showing considerable genetic divergence in the populations isolated by distance. Our study provides evidence of a greater evolutionary independence ofCaulacanthuspopulations, which have undergone a series of allopatric diversification events.
Case report: a precancerous lesion associated with HPV in the anal canal diagnosed by magnifying endoscopy with narrow-band imaging and resected by endoscopic submucosal dissection
Authors: Li Hengcun , Sun Xiujing , Yang Ling , Xu Rui , Li Peng
Published: April 2023

Although anal cancer remains rarely diagnosed in the world, its frequency is rising, especially in high-risk groups. The prognosis of advanced anal cancer is poor. However, there are still few reports on the endoscopic diagnosis and treatment of early anal cancer and its precancerous lesions. A 60-year-old woman was referred to our hospital for endoscopic treatment of a flat precancerous lesion in the anal canal, which was identified by narrow-band imaging (NBI) and confirmed by pathological examination in another hospital. The pathological results showed a high-grade squamous intraepithelial lesion (HSIL) in the biopsy specimen, and immunochemistry staining showed P16 positive, suggesting HPV infection. We performed pre-resection endoscopic examination for the patient. A lesion with a clear margin and tortuous dilated vessels was revealed under magnifying endoscopy with NBI (ME-NBI), which stayed unstained after iodine spraying. The lesion was successfully removed en bloc using ESD without complications, and the resected specimen was a low-grade squamous intraepithelial lesion (LSIL) with positive immunochemistry staining of P16. The patient underwent follow-up coloscopy a year after ESD, and the anal canal healed well with no suspicious lesions found. From this case, we can learn that ESD is safe and effective for curative resection of precancerous lesions of the anal canal.
Combining citizen science and molecular diagnostic methods to investigate the prevalence of Borrelia burgdorferi s.l. and Borrelia miyamotoi in tick pools across Great Britain
Authors: Shan Jinyu , Jia Ying , Hickenbotham Peter , Teulières Louis , Clokie Martha R. J.
Published: April 2023

Lyme disease is the most common tick-borne disease and is caused by a group of bacteria known as Borrelia burgdorferi sensu lato (s.l.) complex. Sharing the same genus as B. burgdorferi, Borrelia miyamotoi is a distinct genotype that causes relapsing fever disease. This emerging tick-borne disease is increasingly becoming a concern in public health. To investigate the prevalence of B. burgdorferi s.l. and B. miyamotoi in ticks first, we developed a PCR (Bmer-qPCR) that targets the phage terminase large subunit (terL) gene carried by B. miyamotoi. A similar approach had been used successfully in developing Ter-qPCR for detecting B. burgdorferi s.l. The terL protein functions as an enzyme in packaging phage DNA. Analytical validation of the Bmer-qPCR confirmed its specificity, efficiency and sensitivity. Second, we designed a citizen science-based approach to detect 838 ticks collected from numerous sites across Great Britain. Finally, we applied Bmer-qPCR and Ter-qPCR to 153 tick pools and revealed that the prevalence of B. burgdorferi s.l. and B. miyamotoi was dependent on their geographical locations, i.e. Scotland showed a higher rate of B. burgdorferi s.l. and lower rate of B. miyamotoi carriage as compared to those of the England data. A pattern of diminishing rate of B. miyamotoi carriage from southern England to northern Scotland was visible. Together, the citizen science-based approach provided an estimation of the carriage rate of B. burgdorferi s.l. and B. miyamotoi in tick pools and a potential spreading pattern of B. miyamotoi from the south to the north of Great Britain. Our findings underscore the power of combining citizen science with the molecular diagnostic method to reveal hidden pattern of pathogen-host-environment interplay. Our approach can provide a powerful tool to elucidate the ecology of tick-borne diseases and may offer guidance for pathogen control initiatives. In an era of limited resources, monitoring pathogens requires both field and laboratory support. Citizen science approaches provide a method to empower the public for sample collection. Coupling citizen science approaches with laboratory diagnostic tests can make real-time monitoring of pathogen distribution and prevalence possible.
Digital health technology to support care and improve outcomes of chronic kidney disease patients: as a case illustration, the Withings toolkit health sensing tools
Authors: Canaud Bernard , Kooman Jeroen , Davenport Andrew , Campo David , Carreel Eric , Morena-Carrere Marion , Cristol Jean-Paul
Published: April 2023

Cardiovascular disease (CVD) is a major burden in dialysis-dependent chronic kidney disease (CKD5D) patients. Several factors contribute to this vulnerability including traditional risk factors such as age, gender, life style and comorbidities, and non-traditional ones as part of dialysis-induced systemic stress. In this context, it appears of utmost importance to bring a closer attention to CVD monitoring in caring for CKD5D patients to ensure early and appropriate intervention for improving their outcomes. Interestingly, new home-used, self-operated, connected medical devices offer convenient and new tools for monitoring in a fully automated and ambulatory mode CKD5D patients during the interdialytic period. Sensoring devices are installed with WiFi or Bluetooth. Some devices are also available in a cellular version such as the Withings Remote Patient Monitoring (RPM) solution. These devices analyze the data and upload the results to Withings HDS (Hybrid data security) platform servers. Data visualization can be viewed by the patient using the Withings Health Mate application on a smartphone, or with a web interface. Health Care Professionals (HCP) can also visualize patient data via the Withings web-based RPM interface. In this narrative essay, we analyze the clinical potential of pervasive wearable sensors for monitoring ambulatory dialysis patients and provide an assessment of such toolkit digital medical health devices currently available on the market. These devices offer a fully automated, unobtrusive and remote monitoring of main vital functions in ambulatory subjects. These unique features provide a multidimensional assessment of ambulatory CKD5D patients covering most physiologic functionalities, detecting unexpected disorders (i.e., volume overload, arrhythmias, sleep disorders) and allowing physicians to judge patient’s response to treatment and recommendations. In the future, the wider availability of such pervasive health sensing and digital technology to monitor patients at an affordable cost price will improve the personalized management of CKD5D patients, so potentially resulting in improvements in patient quality of life and survival.
Prognostic significance and postoperative chemoradiotherapy guiding value of mean platelet volume for locally advanced esophageal squamous cell carcinoma patients
Authors: Zhang Wei , Jia Hongyuan , Chen Xue , Diao Wei , Leng Xuefeng , Cao Bangrong , Wang Yi , Cheng Zhuzhong , Wang Qifeng
Published: April 2023

Objective

To investigate the predicting prognosis and guiding postoperative chemoradiotherapy (POCRT) value of preoperative mean platelet volume (MPV) in patients with locally advanced esophageal squamous cell carcinoma (LA-ESCC).

Methods

We proposed a blood biomarker, MPV, for predicting disease-free survival (DFS) and overall survival (OS) in LA-ESCC patients who underwent surgery (S) alone or S+POCRT. The median cut-off value of MPV was 11.4 fl. We further evaluated whether MPV could guide POCRT in the study and external validation groups. We used multivariable Cox proportional hazard regression analysis, Kaplan–Meier curves, and log-rank tests to ensure the robustness of our findings.

Results

In the developed group, a total of 879 patients were included. MVP was associated with OS and DFS defined by clinicopathological variables and remained an independent prognostic factor in the multivariate analysis (P = 0.001 and P = 0.002, respectively). For patients with high MVP, 5-year OS and 0DFS were significantly improved compared to those with low MPV (P = 0.0011 and P = 0.0018, respectively). Subgroup analysis revealed that POCRT was associated with improved 5-year OS and DFS compared with S alone in the low-MVP group (P < 0.0001 and P = 0.0002, respectively). External validation group analysis (n = 118) showed that POCRT significantly increased 5-year OS and DFS (P = 0.0035 and P = 0.0062, respectively) in patients with low MPV. For patients with high MPV, POCRT group showed similar survival rates compared with S alone in the developed and validation groups.

Conclusions

MPV as a novel biomarker may serve as an independent prognosis factor and contribute to identifying patients most likely to benefit from POCRT for LA-ESCC.
Using preoperative control nutritional status scores as prognostic factors for endometrial cancer
Authors: Yuan Jing , Wang Qing , Cheng Jiumei , Wang JinJuan , Zhang Ying
Published: April 2023

Background

Previous investigations have reported that controlling nutritional (CONUT) status scores, incorporating total cholesterol (TC) and serum albumin (SA) values, and total lymphocyte (LY) counts, are reliable malignant tumor predictors. However, CONUT scores for predicting endometrial cancer (EC) remain unexplored.

Objective

To evaluate preoperative CONUT scores as prognostic factors for postoperative EC.

Methods

We retrospectively evaluated preoperative CONUT scores in 785 surgically resected EC patients at our hospital between June 2012 and May 2016. Using time-dependent receiver operating characteristic (ROC) analyses, patients were split into: 1) CONUT-high (CH) (≥1) and 2) CONUT-low (CL) (<1) groups. Relationships between CONUT scores and different clinicopathological, pathological differentiation, muscle layer infiltration depth, and prognosis factors were examined, and Cox regression analyses performed to assess prognostic values on overall survival (OS) rates.

Results

We assigned 404 (51.5%) and 381 (58.5%) patients to CH and CL groups, respectively. In the CH group, body mass index (BMI), prognostic nutrition index (PNI), and LY/monocyte ratios (LMR) were decreased, however, neutrophil/LY (NLR) and platelet/LY ratios (PLR) were increased. Pathological differentiation analyses showed that G1 proportions were higher in the CL group, while G2 and G3 proportions were more prevalent in the CH group. Muscle layer infiltration depth in CL patients was < 50%, while that it was ≥50% in the CH group. No significant differences in OS rates were recorded between CH and CL groups over 60 months. However long-term survival (LTS) rates after 60 months in the CH group were significantly lower when compared with the CL group, and was more obvious in type II EC patients. Also, periuterine infiltration and preoperative CONUT scores were independent prognostic factors for OS rates as indicated by multi-factor analyses.

Conclusion

CONUT scores not only facilitated the estimation of nutritional status, but were highly beneficial for predicting OS rates in patients with EC after curative resection. CONUT scores provided high predictive values for LTS rates over 60 months in these patients.
Angioimmunoblastic T-cell lymphoma and correlated neoplasms with T-cell follicular helper phenotype: from molecular mechanisms to therapeutic advances
Authors: Lage Luís Alberto de Pádua Covas , Culler Hebert Fabricio , Reichert Cadiele Oliana , da Siqueira Sheila Aparecida Coelho , Pereira Juliana
Published: April 2023

Angioimmunoblastic T-cell lymphoma (AITL) is the second most frequent subtype of mature T-cell lymphoma (MTCL) in the Western world. It derives from the monoclonal proliferation of T-follicular helper (TFH) cells and is characterized by an exacerbated inflammatory response and immune dysregulation, with predisposition to autoimmunity phenomena and recurrent infections. Its genesis is based on a multistep integrative model, where age-related and initiator mutations involve epigenetic regulatory genes, such as TET-2 and DNMT3A. Subsequently, driver-mutations, such as RhoA G17V and IDH-2 R172K/S promote the expansion of clonal TFH-cells (“second-hit”), that finally begin to secrete cytokines and chemokines, such as IL-6, IL-21, CXCL-13 and VEGF, modulating a network of complex relationships between TFH-cells and a defective tumor microenvironment (TME), characterized by expansion of follicular dendritic cells (FDC), vessels and EBV-positive immunoblasts. This unique pathogenesis leads to peculiar clinical manifestations, generating the so-called “immunodysplastic syndrome”, typical of AITL. Its differential diagnosis is broad, involving viral infections, collagenosis and adverse drug reactions, which led many authors to use the term “many-faced lymphoma” when referring to AITL. Although great advances in its biological knowledge have been obtained in the last two decades, its treatment is still an unmet medical need, with highly reserved clinical outcomes. Outside the setting of clinical trials, AITL patients are still treated with multidrug therapy based on anthracyclines (CHOP-like), followed by up-front consolidation with autologous stem cell transplantation (ASCT). In this setting, the estimated 5-year overall survival (OS) is around 30-40%. New drugs, such as hypomethylating agents (HMAs) and histone deacetylase inhibitors (HDAi), have been used for relapsed/refractory (R/R) disease with promising results. Such agents have their use based on a biological rationale, have significant potential to improve the outcomes of patients with AITL and may represent a paradigm shift in the therapeutic approach to this lymphoma in the near future.
Factors affecting the use of herbal medicines for weight loss in overweight and obese adolescents
Authors: Yim Mi Hong , Lee Boram
Published: April 2023

Objectives

Herbal medicine (HM) is widely used to treat obesity in adolescents worldwide since the currently available interventions have low compliance and lack long-term effects and safety data. This study aimed to analyze the factors affecting HM use for weight loss in overweight and obese adolescents.

Methods

A total of 46,336 adolescents were included in this cross-sectional study based on the Korea Youth Risk Behavior Web-Based Survey. Three models of HM use for weigh loss were developed by sequentially adding predisposing, enabling, and need factors according to Andersen's model using multiple logistic regression analyses considering the complex sampling design.

Results

Male and female high school students and students from low perceived household economic status were less likely to use HM for weight loss. Students whose fathers had a college degree or higher, depressed mood, and two or more chronic allergic diseases were more likely to use HM. Male students who perceived their body image as fat or very fat tended to use HM less than those who perceived their body image as very thin, thin, or moderate. Obese female students tended to use HM more than overweight female students.

Conclusion

These results can be used as the bases to promote HM use, provide ideas for future research, and strengthen the health insurance coverage extension for weight loss interventions.
Stoichiometric homeostasis of N:P ratio drives species-specific symbiotic N fixation inhibition under N addition
Authors: Li Qiang , Philp Joshua , Denton Matthew D. , Huang Yingxin , Wei Jian , Sun Huijuan , Li Yang , Zhao Qian
Published: April 2023

Introduction

Symbiotic N fixation inhibition induced by N supply to legumes is potentially regulated by the relative N and P availability in soil. However, the specific responses of different legume species to changes in N:P availability remain unclear, and must be better understood to optimize symbiotic N fixation inputs under N enrichment. This study investigated mechanisms by which soil N and P supply influence the symbiotic N fixation of eight legume species, to quantify the inter-specific differences, and to demonstrate how these differences can be determined by the stoichiometric homeostasis in N:P ratios (HN:P).

Methods

Eight herbaceous legume species were grown separately in outdoor pots and treated with either no fertilizer (control), N fertilizer (14 g N m-2), P fertilizer (3.5 g P m-2) or both N and P fertilizer. Plant nutrients, stoichiometric characteristics, root biomass, non-structural carbohydrates (NSC), rhizosphere chemistry, P mobilization, root nodulation and symbiotic N fixation were measured.

Results

N addition enhanced rhizosphere P mobilization but drove a loss of root biomass and root NSC via exudation of P mobilization compound (organic acid), especially so in treatments without P addition. N addition also induced a 2-14% or 14-36% decline in symbiotic N fixation per plant biomass by legumes in treatments with or without P addition, as a result of decreasing root biomass and root NSC. The changes in symbiotic N fixation were positively correlated with stoichiometric homeostasis of N:P ratios in intact plants without root nodules, regardless of P additions.

Discussion

This study indicates that N addition can induce relative P limitations for growth, which can stimulate rhizosphere P mobilization at the expense of root biomass and carbohydrate concentrations, reducing symbiotic N fixation in legumes. Legume species that had less changes in plant N:P ratio, such as Lespedeza daurica and Medicago varia maintained symbiotic N fixation to a greater extent under N addition.
The psychosocial impact of climate change among smallholder farmers: a potential threat to sustainable development
Authors: Shoko Kori Dumisani
Published: April 2023

Psychosocial impacts of climate change and implications on sustainable development remain unclear. This problem was addressed focusing on smallholder farmers in resettlement areas of Chirumanzu District, Zimbabwe. An Exploratory Descriptive Qualitative research design was adopted. Purposive sampling techniques were used to select 54 farmers who served as main respondents from four representative wards. Data were collected through semi-structured interviews and analyzed using a grounded theory approach. Code groups and codes were established through inductive approaches considering narratives of farmers. Forty psychosocial impacts were established. They were qualitative, intangible, indirect and difficult to measure quantitatively. Farmers agonized over the threat of climate change on farming operations, felt humiliated, and embarrassed over detestable practices they resorted to due to climate change. Some farmers experienced heightened negative feelings, thoughts, and emotions. It was established that psychosocial impacts of climate change have a bearing on sustainable development of emerging rural communities.
Spiritual and religious perspectives in persons with visual impairment due to age-related macular degeneration
Authors: Salzer Carina , Samoila Lacramioara , Mortazavi Moshkenani Hosnasadat , Samoila Ovidiu
Published: April 2023

Introduction

Age-related macular degeneration (AMD) is one of the global leading causes of severe vision loss. Patients suffering from AMD face complex spiritual and mental challenges that have an impact on the course of their disease, their quality of life, and their relationship with their surroundings.

Methods

A survey was carried out using a 21-item questionnaire between August 2020 and June 2021 among 117 patients from different countries to investigate how spirituality, religion, and their way of practicing them affected the experiences and daily lives of patients suffering from AMD, and whether it helped them cope with the disease.

Results

Our study concluded that spirituality and religion are important factors that facilitate patients’ ability to cope with a progressive degenerative disease such as AMD. Patients who are religious are more at peace with having AMD. Practices that contribute to patients being at peace in accepting the disease are regular prayers or meditation. Spirituality and religion are important components that promote a healthier and happier emotional state and mental wellbeing. In particular, by believing that death is not the end, patients feel more hopeful, which helps in their adjustment to a seemingly hopeless health condition. A significant number of AMD patients desire to talk about God with the medical staff. The profile of such patients could be those believing in a higher power, praying often, participating in religious services, being worried about the loss of vision, and needing assistance in daily life.

Discussion

An interdisciplinary and multidimensional team of medical health professionals including mental health workers and chaplains can be of great value in managing persons with AMD.
Cultural considerations in the assessment of sensitivity in low-income caregivers in Ethiopia
Authors: Spinelli Maria , Preti Emanuele , Kassa Temsegen Tadele , Asale Moges Ayele , Goshu Mulat Asnake , Tsega Tigist Wuhib , Gezie Abebaw Minaye , Fasolo Mirco , Mesman Judi
Published: April 2023

Background

Caregiver sensitivity is associated with positive child outcomes, and improving sensitivity is often the aim of parenting-directed interventions. However, sensitivity was conceptualized in Western cultures, and its application in populations with different backgrounds is still limited.

Objective

This study aimed to foster a contextualized cultural understanding of the meaning and nature of sensitivity by assessing the possibility of evaluating sensitivity in a low-income population living in Ethiopia and describing the nature of (in)sensitive parenting. Moreover, the associations between sensitivity and discipline, the quality of the environment, and individual characteristics were explored.

Methods

Parental sensitivity was coded on naturalistic video-recorded observations of free interactions between 25 female primary caregivers and their children. Caregivers completed questionnaires on discipline strategies and the level of satisfaction with the environment (access to basic needs, quality of house condition, community and family support, quality of learning opportunities, and working conditions).

Results

The assessment of sensitivity in this population was possible, with caregivers showing the full range of sensitivity levels. A description of manifestations of sensitivity in this population is provided. A K-means cluster analysis evidenced that high sensitivity was associated with high satisfaction regarding housing conditions and family environment. No association between sensitivity and discipline emerged.

Conclusion

The findings show the feasibility of assessing sensitivity in this sample. The descriptions of observed behaviors contribute to understanding culturally specific aspects of sensitivity to consider when assessing sensitivity in similar populations. The study provides considerations and guidelines to inform the structure of culturally-based interventions to promote sensitive parenting in similar cultural and socioeconomic situations.
The role of rare earth elements and dietary intake in tongue cancer: a mediation analysis in southeast China
Authors: Wang Na , Liu Fengqiong , Chen Yujia , Xie Manling , Gao Bingju , Qiu Yu , Lin Lisong , Shi Bin , Chen Fa , He Baochang
Published: April 2023

Objective

The current research aimed to examine how dietary intake and rare earth elements may affect the development of tongue cancer.

Methods

The serum levels of 10 rare earth elements (REEs) in 171 cases and 171 healthy matched controls were measured by inductively coupled plasma mass spectrometry (ICP-MS). The conditional logistic regression was used to examine the relationship between dietary intake, serum levels of 10 REEs, and tongue cancer. Mediation effect and multiplicative interaction analysis were then performed to estimate the potential contribution of REEs in dietary intake associated with tongue cancer.

Results

Compared with the control group, patients with tongue cancer consumed significantly less fish, seafood, fruit, green leafy vegetables, and non-green leafy vegetables, with higher serum praseodymium (Pr), dysprosium (Dy), and lanthanum (La) levels, and lower serum cerium (Ce) and scandium (Sc) levels. The interaction effect was observed between some REEs and food categories. Green vegetables' impact on the risk of tongue cancer is partially attributed to the La and Thorium (Th) elements (P < 0.05, the mediated proportion were 14.933% and 25.280%, respectively). The effect of non-green leafy vegetables for tongue cancer mediated via Pr, Dy, and Th (P < 0.05, the mediated proportion were 0.408%, 12.010%, and 8.969%, respectively), and the Sc components in seafood (P < 0.05, the mediated proportion was 26.120%) is partly responsible for their influence on the risk of tongue cancer.

Conclusion

The correlation between REEs and dietary intakes for tongue cancer is compact but intricate. Some REEs interact with food intake to influence tongue cancer, while others act as a mediator.
Socioeconomic inequality in the worsening of psychosocial wellbeing via disrupted social conditions during COVID-19 among adolescents in Hong Kong: self-resilience matters
Authors: Chung Gary Ka-Ki , Chan Yat-Hang , Lee Thomas Sze-Kit , Chan Siu-Ming , Chen Ji-Kang , Wong Hung , Chung Roger Yat-Nork , Ho Esther Sui-Chu
Published: April 2023

Background

Adolescents, especially the socioeconomically disadvantaged, are facing devastating psychosocial impact of the COVID-19 pandemic during their critical developmental period. This study aims to (i) examine the socioeconomic patterning of the worsening of psychosocial wellbeing, (ii) delineate the underlying mediating factors (i.e., overall worry about COVID-19, family's financial difficulty, learning problems, and loneliness), and (iii) explore the moderating effect of resilience in the inter-relationship among adolescents under COVID-19.

Methods

Based on maximum variation sampling of 12 secondary schools of diverse socioeconomic background in Hong Kong, 1018 students aged 14-16 years were recruited and completed the online survey between September and October 2021. Multi-group structural equation modeling (SEM) by resilience levels was employed to delineate the pathways between socioeconomic position and the worsening of psychosocial wellbeing.

Results

SEM analysis showed a significant total effect of socioeconomic ladder with the worsening of psychosocial wellbeing during the pandemic in the overall sample (β = −0.149 [95% CI = −0.217 – −0.081], p < 0.001), which operated indirectly through learning problems and loneliness (both p < 0.001 for their indirect effects). Consistent pattern with stronger effect size was observed in the lower resilience group; nonetheless, the associations were substantially mitigated in the higher resilience group.

Conclusion

In addition to facilitating self-directed learning and easing loneliness during the pandemic, evidence-based strategies to build up resilience among adolescents are critical to buffer against the adverse socioeconomic and psychosocial impacts of the pandemic or other potential catastrophic events in the future.
Current status and time trends of lipid and use of statins among older adults in China—real world data from primary community health institutions
Authors: Jiang Junrong , Huang Jun , Deng Hai , Liao Hongtao , Fang Xianhong , Zhan Xianzhang , Wu Shulin , Xue Yumei
Published: April 2023

Background

Elevated serum total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels are established risk factors for cardiovascular diseases, a leading cause of death in China, especially in aged population. We sought to assess the latest levels of serum lipids, prevalence of dyslipidemia and achievement of LDL-C lowering targets among Chinese aged population.

Methods

The data was obtained from the annual health check and medical records in primary community health institutions of Yuexiu District, Guangzhou, Southern China. A sample of approximately 135,000 participants provides comprehensive estimates of the status of cholesterol level and statins use in older adults in China. Clinical characteristics were compared by different age grades, genders and years. Independent risk factors associated with statin use were determined by stepwise logistic regression analysis.

Results

The mean levels of TC, HDL-C, LDL-C, TG were 5.39, 1.45, 3.10, and 1.60 mmol/L, respectively, while the prevalence of high TC, high TG, high LDL-C, and low HDL-C were 21.99, 15.52, 13.26, and 11.92%, respectively. Although statin use showed an increasing trend in both participants > 75 years and ≤75 years of age, the achievement of treatment goals fluctuated between 40.94 and 48.47%, and even seemed to have a downward trend. Stepwise multiple logistic regression analysis further indicated that age, medical insurance, ability of self-care, hypertension, stroke, CAD, and high LDL-C were shown to be associated with statins use (P < 0.05). Those aged ≤75 years old seemed to be less likely to use statin, and those without medical insurance or ability of self-care seemed to be less likely to use statin, too. Patients with hypertension, stroke, CAD and high LDL-C were more inclined to use statins.

Conclusion

Chinese aged population currently experienced high serum lipid levels and prevalence of dyslipidemia. Although an increasing trend was shown in the proportion of high CVD risk and statin use, the achievement of treatment goals seemed to have a downward trend. Improvement of lipid management is necessary in order to reduce the burden of ASCVD in China.
Impact of diabetes on emergency care of acute myocardial infarction patients during the coronavirus disease 2019 pandemic: a nationwide population-based study
Authors: Song Eyun , Hwang Jeongeun , Park Sung Joon , Park Min Jeong , Jang Ahreum , Choi Kyung Mook , Baik Sei Hyun , Yoo Hye Jin
Published: April 2023

Background

Although acute myocardial infarction (AMI) requires timely intervention, limited nationwide data is available regarding the association between disruption of emergency services and outcomes of patients with AMI during the coronavirus disease 2019 (COVID-19) pandemic. Moreover, whether diabetes mellitus (DM) adversely affects disease severity in these patients has not yet been investigated.

Methods

This nationwide population-based study analyzed 45,648 patients with AMI, using data from the national registry of emergency departments (ED) in Korea. Frequency of ED visits and disease severity were compared between the COVID-19 outbreak period (year 2020) and the control period (the previous year 2019).

Results

The number of ED visits by patients with AMI decreased during the first, second, and third waves of the outbreak period compared to the corresponding time period in the control period (all p-values < 0.05). A longer duration from symptom onset to ED visit (p = 0.001) and ED stay (p = 0.001) and higher rates of resuscitation, ventilation care, and extracorporeal membrane oxygen insertion were observed during the outbreak period than during the control period (all p-values < 0.05). These findings were exacerbated in patients with comorbid DM; Compared to patients without DM, patients with DM demonstrated delayed ED visits, longer ED stays, more intensive care unit admissions (p < 0.001), longer hospitalizations (p < 0.001), and higher rates of resuscitation, intubation, and hemodialysis (all p-values < 0.05) during the outbreak period. While in-hospital mortality was similar in AMI patients with and without comorbid DM during the two periods (4.3 vs. 4.4%; p = 0.671), patients with DM who had other comorbidities such as chronic kidney disease or heart failure or were aged ≥ 80 years had higher in-hospital mortality compared with those without any of the comorbidities (3.1 vs. 6.0%; p < 0.001).

Conclusion

During the pandemic, the number of patients with AMI presenting to the ED decreased compared with that of the previous year, while the disease severity increased, particularly in patients with comorbid DM.
A field-based recommender system for crop disease detection using machine learning
Authors: Omara Jonathan , Talavera Estefania , Otim Daniel , Turcza Dan , Ofumbi Emmanuel , Owomugisha Godliver
Published: April 2023

This study investigates crop disease monitoring with real-time information feedback to smallholder farmers. Proper crop disease diagnosis tools and information about agricultural practices are key to growth and development in the agricultural sector. The research was piloted in a rural community of smallholder farmers having 100 farmers participating in a system that performs diagnosis on cassava diseases and provides advisory recommendation services with real-time information. Here, we present a field-based recommendation system that provides real-time feedback on crop disease diagnosis. Our recommender system is based on question–answer pairs, and it is built using machine learning and natural language processing techniques. We study and experiment with various algorithms that are considered state-of-the-art in the field. The best performance is achieved with the sentence BERT model (RetBERT), which obtains a BLEU score of 50.8%, which we think is limited by the limited amount of available data. The application tool integrates both online and offline services since farmers come from remote areas where internet is limited. Success in this study will result in a large trial to validate its applicability for use in alleviating the food security problem in sub-Saharan Africa.