bluuebunny/crossref_metadata_2025 huggingface dataset:
Significant Long-term Variations in Left Ventricular Ejection Fraction Driven by Systemic Vascular Resistance Changes
Authors: MANDRY Damien , GIRERD Nicolas , LAMIRAL Zohra , HUTTIN Olivier , FILIPPETTI Laura , Emilien Micard , BEAUMONT Marine , MOTTOH Marie-Paule Bernadette NCHO , PACE Nathalie , ZANNAD Faïez , ROSSIGNOL Patrick , MARIE Pierre-Yves
Published: June 2021

This study aims to determine whether changes in vascular function parameters, such as systemic vascular resistance (SVR), might explain the significant changes in LV ejection fraction (EF) that may be observed over the long term in subjects with no evident health issues.Subjects with no evident health issues except for hypertension and obesity, underwent MRI with phase-contrast sequences at baseline and at a median follow-up of 5.2 years. Longitudinal changes in EF were analyzed with regard to concomitant changes in the vascular function parameters computed with an MRI flow-sequence.A total of 118 subjects (53±12 years) were included among whom, 52% were women, 26% had hypertension, and 52 % were obese. The longitudinal change in EF was inversely related to concomitant changes in mean and diastolic blood pressure (p=0.030 and p=0.027, respectively) and much more significantly so, in SVR (p<0.001). SVR changes were -8.08±9.21 and +8.14±8.28 mmHg.min.m2.L-1 respectively in subjects with significant increases (n=7) and decreases (n=10) in EF, and 3.32±7.53 mmHg.min.m2.L-1 in subjects with stable EF (n=100) (overall p<0.001). The EF variations of populations with no evident health issues, except for hypertension and obesity, are mostly driven by concomitant changes in arterial function rather than in LV contractility. Clinical Trial Registrations. NCT01716819 and NCT02430805 on the ClinicalTrials.gov site.
Comprehensive Genetic Evaluation of Children With Syndromic Craniosynostosis by a Combination of Cytogenetics, Multiplex Ligation-dependent Probe Amplification and Array-based Comparative Genomic Hybridisation
Authors: Delchev Trayan Nedyalkov , Hadjidekova Savina , Kathom Hadil , Bichev Stoyan , Veleva Tsvetina , Boneva Iliana , Avdjieva-Tzavella Daniela
Published: June 2021

Syndromic craniosynostosis (SC) is a genetically determined premature closure of one or more of the cranial sutures, which may result in severe dysmorphism, increased intracranial pressure along with many other clinical manifestations. The considerable risk of complications along with significant incidence makes these cranial deformations an important medical problem. Despite the efforts to clarify the pathogenesis of SC in recent years, its genetic aspects remain largely unknown.Aiming to elucidate the complex genetic etiology of syndromic craniosynostosis, we conducted an investigation of 39 children, screened systematically with a combination of conventional cytogenetic analysis, multiplex ligation-dependent probe amplification (MLPA) and array-based comparative genomic hybridisation (aCGH).Pathological findings were established in 15.3% (6/39) of the cases using aCGH, in 7.7% (3/39) using MLPA and 2.5% (1/39) using conventional karyotyping. About 12.8% (5/39) of the patients with normal karyotype carried submicroscopic chromosomal rearrangements. Duplications were found to be more common than deletions.Conclusion: The systematic genetic evaluation of children with SC revealed a high prevalence of submicrosopic chromosomal rearrangements (most commonly duplications and gain-of-function variations). This suggests the leading role of those defects in the pathogenesis of syndromic craniosynostosis. The genetic complexity of SC was reaffirmed by the discovery of pathological findings in various chromosomal regions. Certain genes were discussed in conjunction with craniosynostosis.
Abnormal Percent Amplitude of Fluctuation Changes in Patients With Monocular Blindness: a Resting-state Functional Magnetic Resonance Imaging Study
Authors: Yao Fan , Li Qiu-Yu , Shu Hui-Ye , Liang Rong-Bin , Pan Yi-Cong , Zhang Li-Juan , Ge Qian-Min , Shao Yi
Published: June 2021

Purpose: Previous studies on monocular blindness (MB) have mainly focused on concept and impact. The present study measured spontaneous brain activity in MB patients using the percentage of amplitude fluctuation (PerAF) method.Methods: Twenty-nine patients with MB (21 male and 8 female) and 29 age-, gender-, and weight-matched healthy controls (HCs) were recruited. All participants underwent resting state functional magnetic resonance imaging (rs-fMRI). The PerAF method was used to analyze the data and evaluate the spontaneous regional brain activity. The ability of PerAF values to distinguish patients with MB from HCs was analyzed using receiver operating characteristic (ROC) curves, and correlation analysis was used to assess the relationship between PerAF values of brain regions and the Hospital Anxiety and Depression Scale (HADS) scores.Results: PerAF values in Occipital_Mid_L/ Occipital_Mid_R/ Cingulum_Mid_L were significantly lower in patients with MB than in controls. Conversely, values in the Frontal_Sup_Orb_L / Frontal_Inf_Orb_L/ Temporal_Inf_L/ Frontal_Inf_Oper_L were significantly higher in MB patients than in HCs. And the AUC of ROC curves were follows: 0.904, (p＜0.0001; 95% CI: 0.830-0.978) for Frontal_Sup_Orb_L/ Frontal_Inf_Orb_L; Temporal_Inf_L 0.883, (p＜0.0001; 95% CI: 0.794-0.972); Frontal_Inf_Oper_L 0.964, (p＜0.0001; 95% CI: 0.924-1.000), and 0.893 (p＜0.0001; 95% CI: 0.812-0.973) for Occipital_Mid_L; Occipital_Mid_R 0.887, (p＜0.0001; 95% CI: 0.802-0.971); Cingulum_Mid_L 0.855, (p＜0.0001; 95% CI: 0.750-0.960).Conclusion: The results of our study show abnormal activity in some brain regions in patients with MB, indicating that these patients may be at risk of disorder related to these brain regions. These results may reflect the neuropathological mechanisms of MB and facilitate early MB diagnoses.
Strategies for the Purification of β-Clamp in Complex with the CTD of the DnaE of Pol III (α-Subunit)
Authors: Patoli Atif A. , Patoli Bushra B.
Published: June 2021

Structural information on replisome components is required to understand highly co-ordinated events during DNA replication and repair in Escherichia coli. We aimed to purify complexes involving the replicative polymerase α subunit (DnaE) and β-clamp processivity factor (DnaN). DnaN and 255 amino acids long 6xhis tagged C-terminal domain of DnaE bearing consensus iCBM (DnaE905hM ) were over-expressed in E. coli B834 cells separately. Beta-clamp was obtained in soluble fraction while DnaE905hM appeared in insoluble fraction. The insoluble fraction containing over-expressed DnaEΔ905hM was solubilized. The denatured DnaE905hM was bound to affinity column followed by on-column re-folding and binding of the β-clamp. The purification of the complex was achieved on size exclusion column. The expected composition of complexes was a single β-clamp dimer (81.2 kDa) with one DnaE905hM (26 kDa) predicted to elute at ~180 ml and a complex of β-clamp dimer and two molecules of DnaE905M, predicted to elute at ~175 ml. A sharp peak was observed eluting at 173 ml, with more poorly defined, broader peaks eluting at 155, 205 and 220 ml. The analysis through SDS PAGE and Western blot technique using alkaline-phosphatase-conjugated Mouse Anti-Hexa-His antibodies and rabbit polyclonal anti β-clamp IgG antibody indicated most intense band for β-clamp in fraction 21 and DnaE905hM in fraction 22, presumably reflecting monomeric forms of each protein. The presence of fainter bands of both the β-clamp and DnaE905hM throughout fractions 15 to 19, seemed to cover a wide range of potential stoichiometric of complexes.
Identification of prognostic immune-related lncRNA signature predicting the overall survival for colorectal cancer
Authors: Li Jianxin , Han Ting , Wang Xin , Wang Yinchun , Yang Qingqiang
Published: June 2021

Background

Long non-coding RNA (lncRNA) is an important regulator of gene expression and serves fundamental role in immune regulation. The present study aimed to develop a novel immune-related lncRNA signature to accurately assess the prognosis of patients with colorectal cancer (CRC).
Methods

Transcriptome data and clinical information of patients with CRC were downloaded from The Cancer Genome Atlas (TCGA), and the immune-related mRNAs were extracted from immunomodulatory gene datasets IMMUNE RESPONSE and IMMUNE SYSTEM PROCESS based on the Molecular Signatures Database (MSigDB). Then, the immune-related lncRNAs were identified by a correlation analysis between immune-related mRNAs and lncRNAs. Subsequently, univariate, lasso and multivariate Cox regression were used to identify an immune-related lncRNA signature in training cohort, and the predict ability of the signature was further confirmed in the testing cohort and the entire TCGA cohort. Finally, the lncRNA-mRNA co-expression network was established to explore the biological role of the immune-related lncRNA signature.
Results

In total, 272 Immune-related lncRNAs were identified, five of which were applied to construct an immune-related lncRNA signature based on univariate, lasso and multivariate Cox regression analyses. The signature divided patients with CRC into low- and high-risk groups, and patients with CRC in high-risk group had poorer overall survival than those in low-risk group. Univariate and multivariate Cox regression analyses confirmed that the signature could be an independent prognostic factor in human CRC. Furthermore, functional enrichment analysis revealed that the immune-related lncRNA signature was significantly enriched in immune process and tumor classical pathways.
Conclusions

The present study revealed that the novel immune-related lncRNA signature could be exploited as underlying molecular biomarkers and therapeutic targets for the patients with CRC.
Bioaugmentation of Bacillus amyloliquefaciens-Bacillus kochii co-cultivation to improve sensory qualities of flue-cured tobacco
Authors: Wu Xinying , Zhu Pengcheng , Li Dongliang , Zheng TianFei , Cai Wen , Li Jianghua , Zhang Baoyu , zhu Beibei , Zhang Juan , Du Guocheng
Published: June 2021

Flue-cured tobacco (FCT) with irritating and undesirable flavor must be treated with aging process. However, the spontaneous aging usually takes a very long time for the low efficiency. Bioaugmentation with functional strains is a promising method to improve FCT quality with high aging efficiency. To ease the adverse effect of excessive starch or protein content on the FCT quality, we screened B. amyloliquefaciens LB with high alpha-amylase and B. kochii SC with high neutral protease from the FCT microflora with the flow cytometry. The mono, co-culture of strains was subjected to solid-state fermentation with FCT. B. amyloliquefaciens monoculture at 2 days and B. kochii monoculture at 2.5 days achieved the optimum quality. B. amyloliquefaciens-B. kochii co-culture at a ratio of 3:1 fermenting for 2 days demonstrated a more comprehensive quality enhancement and higher functional enzyme activity than mono-cultivation. With the analysis of OPLS-DA model, there were 38 differential compounds between bioaugmentation samples. In co-cultivation, most of Maillard reaction products and terpenoid metabolites were at a higher level than other samples, which promoted an increase in aroma, softness and a decrease in irritation. This result was in line with our design about the quality enhancement of FCT with co-cultivation. In our study, we presented a promising bioaugmentation technique for changing the quality attributes of FCT in a short aging time.
Alterations of structural connectivity and structural co-variance network in focal cortical dysplasia
Authors: Lee Dong Ah , Lee Ho-Joon , Kim Hyung Chan , Park Kang Min
Published: June 2021

Background

The aim of this study was to investigate alterations in structural connectivity and structural co-variance network in patients with focal cortical dysplasia (FCD).
Methods

We enrolled 37 patients with FCD and 35 healthy controls. All subjects underwent brain MRI with the same scanner and with the same protocol, which included diffusion tensor imaging (DTI) and T1-weighted imaging. We analyzed the structural connectivity based on DTI, and structural co-variance network based on the structural volume with T1-weighted imaging. We created a connectivity matrix and obtained network measures from the matrix using the graph theory. We tested the difference in network measure between patients with FCD and healthy controls.
Results

In the structural connectivity analysis, we found that the local efficiency in patients with FCD was significantly lower than in healthy controls (2.390 vs. 2.578, p = 0.031). Structural co-variance network analysis revealed that the mean clustering coefficient, global efficiency, local efficiency, and transitivity were significantly decreased in patients with FCD compared to those in healthy controls (0.527 vs. 0.635, p = 0.036; 0.545 vs. 0.648, p = 0.026; 2.699 vs. 3.801, p = 0.019; 0.791 vs. 0.954, p = 0.026, respectively).
Conclusion

We demonstrate that there are significant alterations in structural connectivity, based on DTI, and structural co-variance network, based on the structural volume, in patients with FCD compared to healthy controls. These findings suggest that focal lesions with FCD could affect the whole-brain network and that FCD is a network disease.
Comparative Parameters of Occult and Multiple Brain Tumors In Human: The Implication for Therapy
Authors: Saganuwan Saganuwan Alhaji
Published: June 2021

Background
Brain cancer treatment is a difficult task, because of complex nature of physico-chemical properties of brain, central nervous system (cns) acting drugs and drug carriers.
Methods
In view of this, literatures were searched with a view to assessing comparative mathematical parameters of occult and multiple primary brain tumors and their therapeutic outcomes. A total of thirteen patients comprised of eight males and five females who had suffered either occult or multiple brain tumors were used for the study. Tumor parameters and their therapeutic prognoses were mathematically determined. The data were analyzed using a modified Kaplan-Meier method at 5 % level of significance.
Results
Findings have shown that occult tumors such as meningiosarcoma (65.4cm3), teratoma (268 cm3), solitary brain tumor (20.6–22.4 cm3) and gliosarcoma (31.1 cm3) as well as multiple primary brain tumors; meningioma/diffuse astrocytoma (47.7 cm3), glioblastoma multiforme/pituitary adenoma (164. 59 cm3) and planum sphenoidale meningioma/pituitary adenoma (26.52 cm3) are deadly. However solitary brain tumor (4.2 cm3), glioblastoma multiforme/pituitary adenoma (12.77 cm3) and multimeningioma/pituitary adenoma (0.70 cm3) have high survival rate. Generally tumor weight (4.2–144.0 g), tumor density (0.24–0.96), total population of tumor cells (9.5 x 108-2.5 x 1011, rate of tumor cell migration (1.10–48.0 cm2/yr) and tumor radius (0.55-4.0 cm) are relatively moderate to very high, signifying that occult brain tumors may generate faster and may be more difficult to treat chemotherapeutically, radiotherapeutically, immunologically and surgically. Brain tumors affect male and female of 2–79 years old.
Conclusions
The locations of tumors are parietal, temporal, frontal, thalamic, frontoparietal, stellar, and planum sphenoidale lobes. Both occult and multiple brain tumors are diagnosed when all forms of therapy would have been useless.
Potential relationship between high wall shear stress and plaque rupture causing acute coronary syndrome
Authors: Fukuyama Yusuke , Otake Hiromasa , Seike Fumiyasu , Kawamori Hiroyuki , Toba Takayoshi , Takahashi Yu , Sasabe Kyohei , Kimura Keisuke , Shite Junya , Kozuki Amane , Iwasaki Masamichi , Takaya Tomofumi , Yasuda Kazunori , Yamaguchi Osamu , Hirata Ken-ichi
Published: June 2021

Purpose: To investigate the detailed relationship between high wall shear stress (WSS) and plaque rupture (PR) in longitudinal and circumferential locations.Methods: Overall, 100 acute coronary syndrome (ACS) patients whose culprit lesions had PR documented by optical coherence tomography (OCT) were enrolled. Lesion-specific three-dimensional coronary artery models were created using OCT data. At the ruptured portion, tracing of the luminal edge of the residual fibrous cap was smoothly extrapolated to reconstruct the luminal contour before PR. Then, WSS was computed from computational fluid dynamics analysis. PR was classified into central-PR and lateral-PR according to the disrupted fibrous cap location.Results: In the longitudinal 3-mm segmental analysis, multivariate analysis demonstrated that higher WSS in the upstream segment was independently associated with Upstream-PR and a thinner fibrous cap was independently associated with Downstream-PR. In PR cross-sections, PR region had a significantly higher average WSS than the non-PR region. In the cross-sectional analysis, peak WSS was most frequently observed in the lateral region (66.7%) in lateral-PR, whereas that in central-PR was most frequently observed in the central region (70%). Multivariate analysis demonstrated that the presence of peak WSS at the lateral region, thinner broken fibrous cap, and larger lumen area were independently associated with lateral-PR, while the presence of peak WSS at the central region and thicker broken fibrous cap were independently associated with central-PR.Conclusions: A combined approach with computational fluid dynamics simulation and morphological plaque evaluation by OCT might help predict future PR-induced ACS events.
The relevance of baseline symptom burden in advanced gastroesophageal cancer to treatment toxicity assessment
Authors: Baxter Mark A , Petty Russell D
Published: June 2021

Advanced gastroesophageal adenocarcinoma (GOA) is a poor prognosis disease associated with significant symptom burden at diagnosis. In this post-hoc analysis of the GO2 trial, we report the baseline symptom burden in the GOA patient cohort. We also demonstrate that by taking pre-treatment symptom burden into consideration, observed treatment related toxicity is significantly lower. We conclude that the reported perceived impact of treatment on toxicity in the GO2 trial was largely driven by baseline disease symptom burden. We propose a need for better methods of reported treatment toxicity in high symptom disease.
Complementary Food Hygiene Practice among Mothers or Caregivers in Bale Zone, Southeast Ethiopia: A Community Based Cross-Sectional Study
Authors: Bedada Shumi , Tegegne Mekonnen , Benti Tomas
Published: June 2021

Introduction:

Diarrhea and other foodborne diseases are a major public health problem which predominantly affects infants and young children. Appropriate complementary food hygiene practice is very important to reduce the prevalence of foodborne illnesses among children. This study is aimed to assess complementary food hygiene practices among mothers of children aged 6–23 months.
Methods

A community based cross-sectional study was conducted in Robe town. Sample of 517 mother-child pairs were selected using systematic sampling techniques. Data was collected using pre-tested and structured questionnaire. Each variable were described by using the frequency and percentage. Bivariate and multivariate logistic regression analyses were used to identify factors associated with complementary food hygiene practice score. Odds ratios with 95% confidence interval were used to assess level of significance.
Results

From a total of 508 mothers that were interviewed, 55% of them scored above the mean score of food hygiene practices. Mothers had higher odds to practice good food hygiene measures than those of aged 6–11 months. Mothers whose child attends growth monitoring session practice good food hygiene than their counterpart. Mothers having media exposure, and having knowledge on critical times of hand washing practice relatively good food hygiene measures. Among food hygiene measures; handwashing practice with water and soap were low before eating food, before feeding children and before preparing food when compared with after visiting toilet and touching dirt.
Conclusions

The study identified food hygiene practices in the current study area were mainly associated with child age, growth monitoring follow-up, maternal awareness about critical times of hand washing, and media exposure. Improving knowledge of mothers on critical times of handwashing, strengthening growth monitoring follow-up and media promotion are important measures to improve food hygiene practices among mothers of infants and young children.
Potensi dan Masalah Destinasi Pariwisata Replika di Daerah Istimewa Yogyakarta
Authors: Ristinanda Amalia Deandra , Nuryanti Wiendu
Published: June 2021

Title: Potential and Problem of Replica Tourism Destinations in Special District of Yogyakarta
Special Region of Yogyakarta is the tourism assets so it has the potential of tourism destinations to grow. The replica tourism destinations grow in contrast to the culture owned by the regions and the community. It is essential to see the condition and the development of the replica tourism destinations, their potentials, their problems and their opportunities as the driving force of tourism distribution. The method used in this research is directive interview. The overall result shown that the condition and the development is unstable, there was a leap of the tourist numbers but then decreasing. The involvement of local community and the increasing of tourism diversity became the potential of these destinations, but they had the problem of being sustainable. The replica tourism destinations grew due to the existence of tourists’ interests and they gave benefit to the local community but as time goes by, they were left since they were temporary.
Transformasi Ruang pada Rumah Pengrajin Gerabah di Desa Pagerjurang, Paseban, Bayat, Klaten
Authors: Pintra Azka , Rahmi Dwita Hadi
Published: June 2021

Title: Space Transformation in Pottery Craftsman’s House in Pagerjurang Village, Paseban, Bayat, Klaten

 

The development of the city of Klaten from year to year has experienced rapidly, it affects all the districts in it, one of which is the Bayat district. Besides in Bayat is also a pottery and religious tourism village. Many people from outside the city visit here. This has made changes and developments in the houses in Bayat. Paseban Village is a village of pottery in Bayat and the majority of the population earns income as pottery artisans. Changes to the layout of the house in Paseban certainly have many factors that influence it. The pattern of home development in Paseban was not all the livelihoods of artisans. It is intended that there is a change in the function of space which was previously used as a dwelling only and now is changing into functions for making pottery. The existence of these changes wants to see what factors influence it. This study uses a qualitative deductive approach, where research is based on a theoretical foundation as a tool for field data collection. Researchers used questionnaires and interviews with Paseban villagers to obtain spatial transformation data. The current condition of the pottery craftsmen's house is seen from the physical form of the house is quite modern, but there are still houses that are still traditional. From interviews with the village head of Paseban, almost 90% have changed.
PHENOMENOLOGY OF COGNITION IN THE CONTEXT OF MANY-SIDED HUMANISM OF STAŅISLAVS LADUSĀNS
Authors:   Institute of Philosophy and Sociology, University of Latvia, KIOPE MĀRA
Published: June 2021

Phenomenology contains potential that can be expanded to include the development of cognitive phenomenology concepts. One of the most notable works in this area is related to the name of Stanislavs Ladusāns (Staņislavs Ladusāns, 1912–1993), the famous Latvian and Brasilian philosopher. The article will outline the key elements of S. Ladusāns’ phenomenology of cognition, showing how his many-sided gnoseology was developed as the basis for multidimensional humanism to transform culture into a more humane one. At first phenomenology of cognition is discussed as the ground of many-sided humanism. The notion of many-sided or multidimensional humanism clearly affirms that human understanding about the human itself is based on a plurality of principles. At the end of the seventies Stanislavs Ladusāns decided to realise the philosophy-as-rigorous-science approach—a clear citation of Husserlian idea—and to concentrate attention on the human person within the manifold relations— providing his/her existential experience. All the system of rigorous science of many-sided humanism should be grounded on the theory of cognition. On the basis of epistemology, Ladusāns wants to build a unified picture of human existence, including the discoveries of many sciences and integrating them into multidimensional humanism through philosophy. Meanwhile the phenomenology of cognition in its final form as it is appears in the monograph Gnosiologia Pluridimensional (1992) was build up by Stanislavs Ladusāns during many decades. One of the first most important episodes in this process was the reinterpretation of the Thomistic concept of induction. Stanislavs Ladusāns deals with the conception of the general critical reflection by demonstrating the judgment-formation of the mind. Ladusāns holds that the sensual experience providing material contents of our knowledge displays certain nexuses between forms of experience, these may be transferred onto general inductive judgements. The second significant episode in the construction of system of the phenomenology of cognition is linked with the concept of “doubling-of-cognition-structure” by which the religious, spiritual experience becomes philosophically legitimate. Even in the case of religion the objective evidence comes first; it gives an opportunity to reason to ascertain about the existence of God. Stanislavs Ladusāns places phenomenology of cognition or many-sided gnoseology at the corner-stone of his programme of cultural regeneration. The capacity of reason is incapable for revigoration of culture—these are overestimated or underestimated—this has to be established in a truly gnoseological investigation. In the context of critics of culture and ideologies is presented Ladusāns’ correspondence with Welte and Heidegger, which reveals the intensive quest for thinking about being that where characteristic of the seventies of the last century aspiring towards the grasping of the Highest Being.
HUSSERL AND DIMENSIONS OF TEMPORALITY: A FRAMEWORK FOR THE ANALYSIS OF TEMPORAL EXPERIENCE
Authors:   Institute of Philosophy and Sociology, University of Latvia, VĒGNERS ULDIS
Published: June 2021

Temporality is one of the key components of our experience, but the experience of time is hardly one and the same for all of us throughout our lives. The experience of time in its entirety is not solid and simple. It is a fluid and complex phenomenon consisting of a multitude of dimensions. In medical phenomenology and phenomenological psychopathology there are ample cases of different temporal experiences analysed in the context of the illness experience. However, only a few attempts have been made to propose a conceptual framework that could not only be used to conduct a concrete analysis in a more systematic manner, but also provide a solid and comprehensive theoretical basis. The aim of this article is to draw on the rich distinctions found in Husserl’s phenomenology to outline a framework of different temporal dimensions for the analysis of temporal experience. The framework could provide conceptual tools to analyse temporal experiences in any field of study that deals with the human experience, including medical phenomenology and phenomenological psychopathology. The resulting analysis would be not only clearer, more comprehensive and precise, but also more systematic and conceptually consistent. The framework consists of fourteen dimensions of temporal experience ordered in seven binary distinctions: (1) change and structure, (2) immanence and transcendence, (3) ownness and intersubjectivity, (4) passivity and activity, (5) receptivity and spontaneity, (6) presentation and representation, (7) unthematized temporality and thematized temporality.
LISTENING: AN INTERDISCIPLINARY PATH TOWARDS LETTING THINGS BE
Authors:   Institute for Philosophical Studies, Science and Research Centre Koper, BJELICA MAJA
Published: June 2021

The Western philosophical and scientific tradition was and still is based on rationalism, objectivity, truths that are all sought from the ocularcentric paradigm. Many thinkers, however, have been recognising this perspective to be exclusive towards the other senses, and therefore insufficient. Listening, as enabled by the auditory sense, has a potential for revealing a deeper sense of being in the world. In this article listening is presented as a possible way towards inhabiting our life-world and nonetheless “to let things be.” In order to do so, an interdisciplinary approach of research is adopted. First, the author offers some perspectives from the field of the ethics of listening, where the thoughts of Lisbeth Lipari, Luce Irigaray and others expose listening as an intersubjective gesture of encounter with the other in acceptance. Through his philosophy of listening, Jean-Luc Nancy, one of the crucial voices in this study, offers an explication of how listening can be the force of liberating sense and senses. Further on, an account on auditory phenomenology is offered, combining it with and stressing the importance of Husserl’s understanding of intersubjectivity. These perspectives are then enriched with echoes from acoustic ecology and its experiences of listening to the environment. The reverberations of multiple voices presented in this text allow for an understanding of listening as an intersubjective and mutually constitutive activity. As such, it involves a liberation of sense and allows for an openness to being and beings.
TECHNO-TELEPATHY & SILENT SUBVOCAL SPEECH-RECOGNITION ROBOTICS: DO ANDROIDS READ OF ELECTRIC THOUGHTS?
Authors:   Faculty of Protestant Theology, Charles University in Prague, BROWER VIRGIL W.
Published: June 2021

The primary focus of this project is the silent and subvocal speech-recognition interface unveiled in 2018 as an ambulatory device wearable on the neck that detects a myoelectrical signature by electrodes worn on the surface of the face, throat, and neck. These emerge from an alleged “intending to speak” by the wearer silently-saying-something-to-oneself. This inner voice is believed to occur while one reads in silence or mentally talks to oneself. The artifice does not require spoken sounds, opening the mouth, or any explicit or external movement of the lips. The essay then considers such subvocal “speech” as a mode of writing or saying and the interior of the mouth or oral cavity as its writing surface. It briefly revisits discussions of telepathy to recontextualize Heidegger’s warning against enframing language exclusively within calculative technics and physiology, which he suggests is detrimental to Mundarten (mouth-modes of regional dialects). It closes in reconsideration of Husserl’s phenomenology of language and meaning in Ideas as it might apply to subvocal speech-recognition interfaces. It suggests ways by which the electrophysiology that the device detects and deciphers (as an alleged intention of a presumed natural language unspoken vocally or aloud) might supplement Husserl’s insinuation of the Leiblichkeit of language through a self-stamping extraction of an extension of meaning.
Geographic and occupational mobility of small-scale fishers of Lake Malawi: an exploratory study of water, sanitation, and hygiene access, Malawi
Authors: Holm Rochelle H. , Chakalamba Tikhala , Ngasama Bwighane , Kapute Fanuel
Published: June 2021

The livelihood of small-scale fishers on the world's freshwater lakes cuts across the Sustainable Development Goal (SDG) 6, which covers water and sanitation, and SDG 8 on economic growth. The aim of this study was to examine the nature and extent of fishers' mobility patterns and access to improved sanitation facilities, safe drinking water, and handwashing practices while at work and home for two fishing camps in Malawi. The study used key informant interviews, questionnaires, water quality testing, and an observational checklist, followed by interviews on fishers' occupational migration. Many fishers (85%; 51/60) live and work in fishing camps with their families. Most fishers only went on day trips, but 8% of their working days were away from the fishing camps. Only eight fishers had safe (0 cfu/100 ml) drinking water at home. Most fishers reported drinking (97%) from and going to the toilet (92%) in the lake during fishing. Historical trends in cholera cases did not correlate with higher periods of migratory behavior of fishers observed in this study. Improving the livelihoods of small-scale fishers requires attention to their culture, the economics of the industry, and geographic criteria while at work and within fishing communities along the shores of Lake Malawi.
Los narradores de la tradición oral: el don impuesto por los seres del otro mundo
Authors: Ávalos Édison Duván
Published: June 2021

En la zona rural de la provincia del Carchi no todas las personas están habilitadas para contar las leyendas de su comunidad; solo unos pocos pueden hacerlo, a saber, aquellos que han visto a los seres del otro mundo, llámense duendes, viudas, aucas o cueches. Se puede decir, entonces, que los seres del otro mundo son quienes habilitan a los narradores en las comunidades, otorgándoles un don para que lo ejecuten por medio de su habla. Planteado el tema desde esta perspectiva religiosa, aquí se indaga sobre los siguientes asuntos: ¿para qué esos seres del otro mundo quieren ser narrados?, ¿mediante qué enunciados lingüísticos los narradores dan cuenta del don recibido?, y ¿para qué le sirve a la comunidad conocer esas narraciones sobre los seres del otro mundo? Las respuestas conducen a considerar que los seres del otro mundo entregan ese don para garantizar su existencia en la memoria colectiva de la comunidad. Pero, al mismo tiempo, con la entrega de ese don les permiten a los narradores generar espacios para distribuir un saber que controla y articula los significados que le dan sentido a la comunidad.
Las lenguas indígenas entre lo urbano y lo rural: La situación de los pueblos Ette Ennaka, Kankuamo, Arhuaco, Kogui y Wayú
Authors: Cossio Romero Pascual Andres
Published: June 2021

Este artículo, de reporte de caso, busca una reflexión en el plano abstracto y concreto sobre la situación de las lenguas indígenas en el Caribe colombiano. El contexto rural y el urbano han presentado diferentes condiciones para el uso de las lenguas indígenas, en el urbano el trabajo formal e informal ha llevado al uso de otras lenguas y en el rural la presencia de grupos armados ha imposibilitado, en algunos casos, el uso de estas lenguas como formas de control. Desde estas dos situaciones se trata de mostrar que la política del bilingüismo como forma de superar las brechas económicas, sociales y culturales en el Caribe colombiano, no ha sido efectiva y se ha validado el uso del español en algunos pueblos indígenas. De esta manera, el adelanto investigativo que acá se presenta tiene como objetivo analizar la situación del uso de las lenguas indígenas en el contexto rural y urbano de los pueblos Ette Ennaka, Kankuamo, Arhuaco, Kogui, Wayú.
Outsü, enfermedades y práctica curativa ritual en los Wayuu de la Media Guajira, Colombia
Authors: Serrano López Silvia Rubiela
Published: June 2021

Este artículo es producto de una investigación que tuvo como objetivo documentar en el siglo XXI las prácticas de curación indígena wayuu desarrolladas en la comunidad de Wararalain del departamento de La Guajira, Colombia. Esas prácticas las realiza la mujer outsü en contextos rituales, en medio de unas problemáticas sociales, ambientales, de seguridad y abandono por parte del Estado colombiano, en el que la cultura y la vida de todos los miembros de ese pueblo se encuentra en una constante amenaza, convirtiendo a los wayuu en personas con especial condición de vulnerabilidad. Por ser una antropóloga nativa, consideré que la metodología apropiada debía ser dialógica, por ello usé el método etnográfico que fue enriquecido con conversaciones temáticas con personas mayores, jóvenes y mujeres curadoras de una misma comunidad, en donde los espacios de diálogo los asumí como aprendizaje y a los wayuu como mis mentores. Mi argumento es que las curaciones wayuu en contextos rituales se caracterizan por la relación dialógica e intersubjetiva entre la mujer sanadora –outsü-, su espíritu auxiliar –aseyuu-, objetos de poder, el enfermo y su familia. Todo esto es posible a través de los sueños, voces y cantos como parte de la práctica curativa de su sistema de salud, ya que estos definen el tipo de enfermedad, como prevenirla y curarla. Esas prácticas curativas en la comunidad se complementan, en determinados casos, con la asistencia del enfermo al sistema biomédico que le ofrece el Estado colombiano, lo cual ha generado diálogos y conflictos entre ambos sistemas de salud. El referente teórico que utilicé como guía para la investigación involucra campos analíticos complementarios que han sido abordados desde la disciplina antropológica y las ciencias sociales, como son las discusiones acerca de lo simbólico en contextos rituales de sanación; lo onírico como categoría transversal; el chamanismo, el cual problematizo y presento las concepciones que han planteado diferentes autores y que en el caso de los wayuu esa categoría impide dar cuenta de especificidades; también analizo nociones de salud y enfermedad que algunas comunidades indígenas poseen y que se han plasmado en investigaciones etnográficas.
An Overview of Phytotherapy Used in the Management of Type II Diabetes
Authors: Sharma Alok , Chawla Rakesh , Kaur Jasleen , Madaan Reecha
Published: June 2021

:

Diabetes mellitus is related to unconstrained high blood sugar and linked with long-term
impairment, dysfunction and failure of several organs. Since 1980, the global frequency of diabetes
has almost doubled in the adult population. In very rare cases due to poor prevention and management
programs, diabetes causes worsening of health and reduced lifespan of the world population,
thus impacting on the world’s economy. Supplements, however, help in the improvement of nutritional
deficiencies. Phytotherapeutics has the advantage of being economical and easy to access
with marginal side effects. So, it is a preferred candidate for the management of diabetes. Currently,
a multitude of pharmaceuticals are used which are obtained from natural sources having medicinal
properties. The mechanistic approaches are based on the regulation of insulin signaling pathways,
translocation of GLUT-4 receptors and/or activation of PPAR γ. These natural compounds include
numerous flavonoids which help in preventing glucose absorption by preventing the absorption
of α-amylase and α-glucosidase. But to validate the efficacy and safety profile of these compounds,
detailed validatory clinical studies are required. This review majorly focuses on the mechanistic
approaches of various naturally derived compounds relevant for the condition of Diabetes
Mellitus.
The Impact of Universal Test and Treat Program on Highly Active Anti Retroviral Therapy Outcomes (Coverage, Adherence and Lost to Follow Up) at Wangaya Hospital in Denpasar, Bali-Indonesia: A Retrospective Cohort Study
Authors: Suryana Ketut
Published: June 2021

Background:

World Health Organization (WHO) (2015) recommended that all people diagnosed with human immunodeficiency virus (HIV)-positive initiate Highly Active Anti Retroviral Therapy (HAART) immediately (less than a week), irrespective of CD4 count (Universal Test and Treat / UTT) Program.

Objective:

To evaluate the impact of UTT as a current therapeutic program on HIV treatment outcomes, coverage, adherence, and lost to follow-up (LTFU) at Wangaya Hospital in Denpasar, Bali, Indonesia.

Methods:

A Retrospective cohort study was conducted during July 2017 - June 2018 (Pre-UTT) and September 2018 – August 2019 (Post-UTT). Around 402 medical records were selected, reviewed, and enrolled. Data were analyzed using SPSS software for windows version 24.0. Bivariate analysis (Chi-square test) was performed on all variables with a statistically significant t level of 0.05.

Results:

Among 4,322 new visitors; 3,585 (82.95%) agreed to take HIV test and 402(11.21%) were confirmed HIV reactive. Most participants confirmed HIV reactive occured at age 25-34 years old and 230 (57.21%) were male. The majority education level were primary (Junior high school) 302(75.12%), 379(94.28%) were employed and 281 (69.90%) stayed in Denpasar. About 350 (87.06%) received HAART, 298 (85.14%) with high adherence and 52 (14.86%) LTFU. Pre-UTT, HAART coverage; 83.03% (181), were statistically significant increased to 91.85% (169) post UTT (p=0.000). High adherence pre-UTT; 79.56% (144) was significantly increased to 91.12% (154) post UTT (p=0.006) and LTFU were significantly decreased; 20.44% (37) to 8.87% (15) (p=0.006).

Conclusion:

UTT program significantly improve the HIV treatment outcome (increased coverage, adherence, and decreased LTFU).
CHANGES OF mRNA GENE EXPRESSION LEVEL OF AIRE, DEAF1, FOXP3, CTLA4 AND IL-10 IN THE OFFSPRING OF RATS WITH EXPERIMENTAL GESTATIONAL DIABETES AND IN CONDITIONS OF INSULIN ORAL TOLERANCE FORMATION
Authors: Prozorova T. M. , Kamyshnyy O. M.
Published: June 2021

Using molecular genetic and immunofluorescence techniques it was investigated the mRNA gene expression level of Aire, Deaf1, Foxp3, Ctla4 and Il-10 in the offspring of rats with experimental gestational diabetes and in conditions of insulin oral tolerance formation. To determine the level of mRNA it was studied gene RT-PCR and was performed in real time thermocycler CFX96 ™ RealTime PCR Detection Systems («Bio-Rad Laboratories, Inc.», USA). It was observed such violations of immunotolerance: AIRE gene repression, reduced mRNA levels of Deaf1 and the transcription factor Foxp3. Numbers of T-regulatory cells were decreased, which was confirmed by inhibition of gene expression cytokine Il-10 and the negative Ctla4 costimulatory molecule. Oral injection of insulin during first 2 weeks compensated these changes. It caused transcriptional activation of the gene AIRE, Deaf1, Foxp3, Ctla4 and Il-10, increased the number of Foxp3+ cells in mesenteric lymph nodes.
CASE OF PAROXYSMAL HYPERTENSION IN PATIENTS WITH HYPOTHYROIDISM
Authors: Kravchun N. A. , Zemlianitsyna O. V. , Polozova L. G. , Polozova L. G. , Kurilo O. D. , Cherniavskaya I. V.
Published: June 2021

It was presented clinical case shows that hypertension syndrome in patients with endocrine pathology, may be due not only to endocrine disorders. Be aware of the genesis of renal hypertension and include study levels of renin, aldosterone and aldosterone-renin ratio (ARR) into a plan for evaluation of patients with hypertension. Determination of renin and ARR was enough informative and allowed to suspect, and subsequently to identify the abnomality of kidney blood vessels, contributing to the appointment of adequate therapy
OXIDATIVE STRESS AS THE PATHOPHYSIOLOGICAL MECHANISMS IN THE DEVELOPMENT OF DIABETIC MACROANGIOPATHY AND PERSPECTIVES OF ITS CORRECTION BY FLAVONOIDS
Authors: Gorbenko Nataliia , Ivanova Olha , Borikov Oleksii
Published: June 2021

The review elucidates the role of oxidative stress in the pathogenesis of diabetic cardiovascularcomplications. It was analyzed the main reasons for excessive production of reactive oxygen speciesin the conditions of hyperglycemia and the basic mechanisms of their damaging effect on the morphological and functional state of the myocardium and endothelium. It was considered theperspective of natural antioxidants, such as flavonoids, for the prevention and treatment of diabeticmacroangiopathy. It was made a retrospective analysis of own researches devoted to the quercetin effect on the main factors of cardiometabolic risk at the insulin resistance syndrome
Trends in Health Quality-related Publications over the past three decades. (Preprint)
Authors: Mendlovic Joseph , Mimouni Francis B , Arad Iris , Heiman Eyal
Published: June 2021

BACKGROUND

Quality assessment in health care is a process of planned activities whose ultimate goal is to achieve a continuous improvement of medical care through the evaluation of structure, process, and outcome measures. Physicians and health care specialists involved with quality issues are faced with an enormous and nearly always increasing amount of literature to read and integrate

OBJECTIVE

To test the hypothesis that the number of publications in the field of health care quality increases over time, and particularly the number of high-evidence journal articles such as randomized control trials, systematic reviews, and ultimately, practice guidelines.

METHODS

We used MEDLINE database to retrieve relevant articles published between during the 29 year-period between 1/1/1989 and 12/31/2018. The search was conducted in March 2021. Publications from 2019 and 2020 were excluded because of incomplete data. We used the keywords "quality care", "quality management", "quality indicators" and "quality improvement” and limited the search fields to title and abstract.

RESULTS

During the 29-year evaluation period there was a significant cubic increase in the number of publications both in total number of publications and in the variety of publication types studied The rate of increase varied for different types of publications, with the largest increase in reviews, and the smallest increase in case reports. There was a systematic stagnation or even decrease in the number of publications starting in 2015 regardless of publication type.

CONCLUSIONS

Over the past 29 years the field of quality in health care has seen a significant yearly increase of published original studies with a relative stagnation since 2015. We suggest that contributors to this dynamic field of research should focus on producing more evidence based publications and guidelines