bluuebunny/crossref_metadata_2025 huggingface dataset:
The Influence of Women on Boards on the Relationship between Executive and Employee Remuneration
Authors: Gallén María L. , Peraita Carlos
Published: August 2024

The growing presence of women at the top of companies has sparked interest in examining their role in the remuneration gap between senior managers and employees. This article analyses the traditional Chief Executive Officer (CEO)-to-employee pay ratio but includes a new relation, the senior-management-to-employee pay ratio, and extends the research by including six positions for women in company management: on the board of directors, executive directors, CEOs, proprietary directors, independent directors, and senior managers. The study is based on a sample of 77 listed companies in Spain from 2015 to 2022 and the panel data models have been estimated using the Generalised Method of Moments (GMM). The main findings indicate that the proportion of women in different categories of board and senior management positions has a positive effect on the CEO-to-employee pay ratio, especially in companies with higher market capitalisation. In contrast, the proportion of women in senior management positions has a negative effect on the CEO-to-employee pay ratio in all the samples analysed. Government agencies should prioritise the participation of women in non-board senior management positions in order to at least reduce the pay gap between senior managers and employees.
Road Network Intelligent Selection Method Based on Heterogeneous Graph Attention Neural Network
Authors: Zheng Haohua , Zhang Jianchen , Li Heying , Wang Guangxia , Guo Jianzhong , Wang Jiayao
Published: August 2024

Selecting road networks in cartographic generalization has consistently posed formidable challenges, driving research toward the application of intelligent models. Despite previous efforts, the accuracy and connectivity preservation in these studies, particularly when dealing with road types of similar sample sizes, still warrant improvement. To address these shortcomings, we introduce a Heterogeneous Graph Attention Network (HAN) for road selection, where the feature masking method is initially utilized to assess the significance of road features. Concentrating on the most relevant features, two meta-paths are introduced within the HAN framework: one for aggregating features of the same road type within the first-order neighborhood, emphasizing local connectivity, and another for extending this aggregation to the second-order neighborhood, capturing a broader spatial context. For a comprehensive evaluation, we use a set of metrics considering both quantitative and qualitative aspects of the road network. On road types with similar sample sizes, the HAN model outperforms other models in both transductive and inductive tasks. Its accuracy (ACC) is higher by 1.62% and 0.67%, and its F1-score is higher by 1.43% and 0.81%, respectively. Additionally, it enhances the overall connectivity of the selected network. In summary, our HAN-based method provides an advanced solution for road network selection, surpassing previous approaches in terms of accuracy and connectivity preservation.
Unveiling the Role of HGF/c-Met Signaling in Non-Small Cell Lung Cancer Tumor Microenvironment
Authors: Yao Shuxi , Liu Xinyue , Feng Yanqi , Li Yiming , Xiao Xiangtian , Han Yuelin , Xia Shu
Published: August 2024

Non-small cell lung cancer (NSCLC) is characterized by several molecular alterations that contribute to its development and progression. These alterations include the epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), human epidermal growth factor receptor 2 (HER2), and mesenchymal–epithelial transition factor (c-MET). Among these, the hepatocyte growth factor (HGF)/c-MET signaling pathway plays a crucial role in NSCLC. In spite of this, the involvement of the HGF/c-MET signaling axis in remodeling the tumor microenvironment (TME) remains relatively unexplored. This review explores the biological functions of the HGF/c-MET signaling pathway in both normal and cancerous cells, examining its multifaceted roles in the NSCLC tumor microenvironment, including tumor cell proliferation, migration and invasion, angiogenesis, and immune evasion. Furthermore, we summarize the current progress and clinical applications of MET-targeted therapies in NSCLC and discuss future research directions, such as the development of novel MET inhibitors and the potential of combination immunotherapy.
Automatic Detection of the EEG Spike–Wave Patterns in Epilepsy: Evaluation of the Effects of Transcranial Current Stimulation Therapy
Authors: Olejarczyk Elzbieta , Sobieszek Aleksander , Assenza Giovanni
Published: August 2024

This study aims to develop a detection method based on morphological features of spike–wave (SW) patterns in the EEG of epilepsy patients and evaluate the effect of cathodal transcranial direct current stimulation (ctDCS) treatment. The proposed method is based on several simple features describing the shape of SW patterns and their synchronous occurrence on at least two EEG channels. High sensitivity, specificity and selectivity values were achieved for each patient and condition. ctDCS resulted in a significant reduction in the number of detected patterns, a decrease in spike duration and amplitude, and an increased spike mobility. The proposed method allows efficient identification of SW patterns regardless of brain condition, although the recruitment of patterns may be modified by ctDCS. This method can be useful in the clinical evaluation of ctDCS effects.
TNFα-Induced Inflammation Model—Evaluation of Concentration and Passage-Dependent Effects on Bovine Chondrocytes
Authors: Ossendorff Robert , Wang Su , Kurth Sarah , Jaenisch Max , Assaf Elio , Strauss Andreas C. , Bertheloot Damien , Welle Kristian , Burger Christof , Wirtz Dieter C. , Schildberg Frank A.
Published: August 2024

Inflammation models are widely used in the in vitro investigation of new therapeutic approaches for osteoarthritis. TNFα (tumor necrosis factor alpha) plays an important role in the inflammatory process. Current inflammation models lack uniformity and make comparisons difficult. Therefore, this study aimed to systematically investigate whether the effects of TNFα are concentration-dependent and whether chondrocyte expansion has an effect on the inflammatory model. Bovine chondrocytes were enzymatically isolated, expanded to passages 1–3, and transferred into a 3D pellet culture. Chondrocyte pellets were stimulated with recombinant bovine TNFα at different concentrations for 48 h to induce inflammation. Gene expression of anabolic (collagen 2, aggrecan, cartilage oligomeric protein (COMP)), catabolic (matrix metalloproteinases (MMP3, MMP13)), dedifferentiation (collagen 1) markers, inflammation markers (interleukin-6 (IL-6), nuclear factor kappa B (NFkB), cyclooxygenase-2 (COX), prostaglandin-E-synthase-2 (PTGES2)), and the apoptosis marker caspase 3 was determined. At the protein level, concentrations of IL-6, nitric oxide (NO), and sulfated glycosaminoglycans (GAG) were evaluated. Statistical analysis was performed using the independent t-test, and significance was defined as p < 0.05. In general, TNFα caused a decrease in anabolic markers and an increase in the expression of catabolic and inflammatory markers. There was a concentration-dependent threshold of 10 ng/mL to induce significant inflammatory effects. Most of the markers analyzed showed TNFα concentration-dependent effects (COMP, PRG4, AGN, Col1, MMP3, and NFkB). There was a statistical influence of selected gene expression markers from different passages on the TNFα chondrocyte inflammation model, including Col2, MMP13, IL-6, NFkB, COX2, and PTGES2. Considering the expression of collagen 2 and MMP3, passage 3 chondrocytes showed a higher sensitivity to TNFα stimulation compared to passages 1 and 2. On the other hand, MMP13, IL-6, NFkB, and caspase 3 gene expression were lower in P3 chondrocytes compared to the other passages. On the protein level, inflammatory effects showed a similar pattern, with cytokine effects starting at 10 ng/mL and differences between the passages. TNFα had a detrimental effect on cartilage, with a clear threshold observed at 10 ng/mL. Although TNFα effects showed concentration-dependent patterns, this was not consistent for all markers. The selected passage showed a clear influence, especially on inflammation markers. Further experiments were warranted to explore the effects of TNFα concentration and passage in long-term stimulation.
The AP-2 Family of Transcription Factors—Still Undervalued Regulators in Gastroenterological Disorders
Authors: Yu Yi-Jin , Kołat Damian , Kałuzińska-Kołat Żaneta , Liang Zhu , Peng Bo-Qiang , Zhu Yun-Feng , Liu Kai , Mei Jia-Xin , Yu Gang , Zhang Wei-Han , Chen Xiao-Long , Yang Kun , Hu Jian-Kun , Zhao Lin-Yong
Published: August 2024

Activating enhancer-binding protein 2 (AP-2) is a family of transcription factors (TFs) that play crucial roles in regulating embryonic and oncogenic development. In addition to splice isoforms, five major family members encoded by the TFAP2A/B/C/D/E genes have been identified in humans, i.e., AP-2α/β/γ/δ/ε. In general, the first three TFs have been studied more thoroughly than AP-2δ or AP-2ε. Currently, there is a relatively limited body of literature focusing on the AP-2 family in the context of gastroenterological research, and a comprehensive overview of the existing knowledge and recommendations for further research directions is lacking. Herein, we have collected available gastroenterological data on AP-2 TFs, discussed the latest medical applications of each family member, and proposed potential future directions. Research on AP-2 in gastrointestinal tumors has predominantly been focused on the two best-described family members, AP-2α and AP-2γ. Surprisingly, research in the past decade has highlighted the importance of AP-2ε in the drug resistance of gastric cancer (GC) and colorectal cancer (CRC). While numerous questions about gastroenterological disorders await elucidation, the available data undoubtedly open avenues for anti-cancer targeted therapy and overcoming chemotherapy resistance. In addition to gastrointestinal cancers, AP-2 family members (primarily AP-2β and marginally AP-2γ) have been associated with other health issues such as obesity, type 2 diabetes, liver dysfunction, and pseudo-obstruction. On the other hand, AP-2δ has been poorly investigated in gastroenterological disorders, necessitating further research to delineate its role. In conclusion, despite the limited attention given to AP-2 in gastroenterology research, pivotal functions of these transcription factors have started to emerge and warrant further exploration in the future.
Osteoarthritis in People with Multiple Sclerosis: A Systematic Review and Meta-Analysis
Authors: Giannopapas Vasileios , Smyrni Vassiliki , Kitsos Dimitrios K. , Stasi Sophia , Chasiotis Athanasios K. , Moschovos Christos , Papagiannopoulou Georgia , Stavrogianni Konstantina , Kosmidou Maria , Bakalidou Daphne , Tzartos John S. , Tsivgoulis Georgios , Giannopoulos Sotirios
Published: August 2024

Background: Arthritis, particularly osteoarthritis (OA), is a common synovial condition observed in individuals with multiple sclerosis (MS). Despite its high prevalence and significant impact on the quality of life of MS individuals, there is a gap in the current literature regarding the prevalence of OA in this population and its relation to MS pathology. This systematic review and meta-analysis aimed to estimate the prevalence of OA in the MS population and explore potential associations with demographic and MS-specific characteristics. Methods: Adhering to PRISMA guidelines, a systematic search of the MEDLINE PubMed, Scopus and Google Scholar databases was conducted. Results: Fifteen studies were included in the systematic review and meta-analysis. The aggregated prevalence of OA in the MS population was 27% (95% CI: 15–40%), with substantial heterogeneity (I2 = 99.9%). Sensitivity analysis, excluding one study, showed a prevalence of 21% (95% CI: 16–28%). The risk ratio of OA in MS versus controls was 1.07 (95% CI: 0.84–1.37), indicating no significant difference. Meta-regression revealed no associations between OA prevalence and age or disease duration in MS patients. Conclusions: This study reports a 21–27% prevalence of OA in people with MS. Understanding the implications of OA in pain and mobility domains, as well as the challenges in distinguishing OA symptoms from MS manifestations, underscores the need for further research to elucidate the pathophysiological mechanisms and interactions between these conditions. Additional studies are warranted to enhance clinical management and improve outcomes for individuals with MS and co-existing OA.
Mobility Requirements and Joint Loading during Straight Walking and 90° Turns in Healthy Older People and Those with Hip Osteoarthritis
Authors: Steingrebe Hannah , Sell Stefan , Stein Thorsten
Published: August 2024

Background/Objectives: Hip mobility and joint loading in hip osteoarthritis (HOA) patients are mostly assessed during straight walking. Yet, mobility limitations in the frontal and transverse planes are rarely found during this task in subjects with mild-to-moderate symptoms. Turning movements are frequently encountered during everyday life and might require larger hip mobility compared to straight walking, especially in the frontal and transverse planes. Thus, hip mobility and hip loading during straight walking and 90° turns in persons with HOA and healthy older adults were compared in this study. Methods: A retrospective analysis was conducted on 21 subjects with mild-to-moderate HOA and 21 healthy controls. Hip angles and moments were assessed during straight walking and 90° step and spin turns. Gait analysis was conducted using a motion capture system and a force plate. Group and movement task differences were assessed with a mixed-model ANOVA. Results: Peak abduction and adduction angles were largest during the step and spin turn, respectively, as were the group differences between HOA subjects and healthy subjects. Both turns require a greater transverse hip range of motion compared to straight walking. Limitations in transverse hip mobility in the HOA group were especially prominent during the step turn. Both turns cause higher joint moments than straight walking. Conclusions: The additional inclusion of 90° step and spin turns into gait analysis can enhance early identification of hip mobility limitations in the frontal and transverse planes in subjects with mild-to-moderate hip osteoarthritis. Early diagnosis is crucial for the timely application of conservative treatment strategies.
Absolute Stenosis Measures of Renal Artery Independently Influence Kidney Perfusion in Contrast-Enhanced Multidetector Computed Tomography
Authors: Lubas Arkadiusz , Zegadło Arkadiusz , Frankowska Emilia , Jędrych Ewelina , Lubas Tymoteusz , Grzywacz Anna , Leśniak Ksymena , Niemczyk Stanisław
Published: August 2024

Background: A renal artery lumen reduction of ≥60% indicates hemodynamically significant stenosis and is one of the main criteria for invasive revascularization. We hypothesize that direct parameters describing renal artery stenosis (RAS) could better correlate with renal blood flow and improve the criterion for revascularization. This study aimed to investigate RAS parameters independently associated with renal blood flow estimated in contrast-enhanced multidetector computed tomography (CE-MDCT). Methods: Ultrasound Doppler dynamic renal cortical perfusion (dRCP), CE-MDCT with cortical blood flow (CBF), and RAS assessment in the form of cross-sectional area reduction (CSAR), maximal diameter reduction (MaxDR), mean diameter (MeD), and minimal diameter (MinD) were investigated. Results: CBF correlated with CSAR (r = −0.422, p = 0.003), MeD (r = 0.344, p = 0.005) and MinD (r = 0.348, p= 0.005), whereas RCP correlated only with MeD (r = 0.357, p = 0.005) and MinD (r = 0.427, p< 0.001). In multivariable regression, only MeD was independently associated with CBF (R2 = 0.179; p < 0.001), and MeD < 3.5 mm substantially indicated CBF < 175 mL/100 g/min in ROC analysis. Conclusions: The directly measured mean diameter of RAS is independently associated with renal cortex blood flow and is probably a more appropriate parameter for the invasive RAS treatment criterion.
Exploring the Relationship between Acute Coronary Syndrome, Lower Respiratory Tract Infections, and Atmospheric Pollution
Authors: Muszyński Paweł , Pawluczuk Elżbieta , Januszko Tomasz , Kruszyńska Joanna , Duzinkiewicz Małgorzata , Kurasz Anna , Bonda Tomasz A. , Tomaszuk-Kazberuk Anna , Dobrzycki Sławomir , Kożuch Marcin
Published: August 2024

Background: Respiratory infections were found to be connected with the incidence of acute coronary syndrome (ACS). The proposed pathway of this connection includes inflammation, oxidative stress, pro-coagulation, and atherosclerotic plaque destabilization. This can cause rapture and thrombus formation, leading to ACS. Our study aimed to assess the risk factors for coronary artery thrombosis as a manifestation of ACS and for lower respiratory tract infections (LRTIs) in patients with ACS. Methods: The study included 876 patients with ACS from January 2014 to December 2018. Both the clinical data and air pollution data were analyzed. Statistical tests used for analysis included Student’s t-test, the Mann–Whitney U-test, the Chi-squared test, and the odds ratio Altman calculation. Results: LRTIs were found in 9.13% patients with ACS. The patients with LRTI had a higher risk of coronary artery thrombosis (OR: 2.4903; CI: 1.3483 to 4.5996). Moreover, they had increased values of inflammatory markers, were older, had a lower BMI, and a higher rate of atrial fibrillation. The average atmospheric aerosols with a maximum diameter of 2.5 μm (PM2.5 concentration) from three consecutive days before hospitalization for ACS were higher in patients with LRTI. Conclusions: The occurrence of coronary artery thrombosis was higher among the patients with LRTI during ACS. PM2.5 exposition was higher in the three consecutive days before hospitalization in patients with LRTI during ACS.
Long-Term Follow-Up Regarding Pain Relief, Fertility, and Re-Operation after Surgery for Deep Endometriosis
Authors: Drechsel-Grau Alexander , Grube Marcel , Neis Felix , Schoenfisch Birgitt , Kommoss Stefan , Rall Katharina , Brucker Sara Y. , Kraemer Bernhard , Andress Juergen
Published: August 2024

Background: Endometriosis is known to be a common chronic disease that often affects the quality of life of patients. Especially for deep endometriosis (DE), the most challenging form of the disease, surgery remains an important component of treatment. However, long-term outcomes after surgery are poorly studied. Therefore, we aimed to evaluate the postoperative clinical course of women with DE who underwent surgery, particularly with regard to pain relief, fertility, and re-operations. Methods: Thus, women who underwent surgical treatment for DE between 2005 and 2015 were included in this retrospective questionnaire-based analysis. Results: A total of 87.0% of the patients who underwent surgery for pain reported a postoperative relief of their complaints. Moreover, 44.6% even stated that they were free of pain at the time of the questionnaire. Patients who underwent surgery for infertility and tried to become pregnant postoperatively gave birth to a child in 45.9% of cases. Approximately one-third of the patients had to undergo another surgery because of endometriosis-related symptoms. The main reasons for re-operation were pain and infertility. The median time to re-operation was 2.1 years. Conclusions: In this extraordinarily long follow-up with a remarkable response rate, we show that surgical treatment of DE leads to pain relief and improved fertility in most cases. However, the risk of recurrence and the need for re-operation remains remarkable.
Characterization of a Romanian Pediatric Population with Eosinophilic Esophagitis
Authors: Tincu Iulia Florentina , Bordei Luiza Elena , Gales Lucica Luminita , Duchi Larisa Alexandra , Dobrescu Loredana , Chenescu Bianca Teodora
Published: August 2024

Background/objectives: An increase in the incidence of eosinophilic esophagitis (EoE) in children has been reported worldwide in the last decade. We conducted a study in a tertiary pediatric gastroenterology unit aimed at analyzing the clinical manifestations, biochemical markers, and endoscopic features of children with EoE in comparison to patients with non-eosinophilic esophagitis. Methods: This is a prospective analysis involving children with symptoms related to esophageal dysfunction, who had esophagogastroduodenoscopies with esophageal biopsies between January 2021 and April 2024 at “Dr. Victor Gomoiu” Clinical Children’s Hospital, in Bucharest, Romania. For the analysis, patients were considered in either Group 1, classified as EoE, or in Group 2, classified as reflux esophagitis. Results: Among the total of 72 patients diagnosed with esophagitis, 17 patients (Group 1—study group) were classified as EoE and 55 were classified as reflux esophagitis (Group 2—control group). The sex ratio analysis showed a male predominance in the study group (71% vs. 32%, p = 0.002). The main symptoms were regurgitation, eructation, and nausea. Dysphagia was present in two (11.76%) patients from Group 1. Eosinophilia was more prevalent in the EoE group than in the individuals with gastroesophageal reflux disease (GERD) (10 (58.85%) vs. 10 (18.18%, p = 0.001)), as well as the total IgE (11 (64.70%) vs. 6 (10.9%, p = 0.001)). Conclusions: Pediatric gastroenterologists need to be aware of EoE atypical presentation and perform adequate biopsies, mainly in children with refractory GERD-like symptoms, dysphagia, and food bolus impaction. Further analyses in terms of prognosis and treatment response should be addressed in longitudinal studies.
Unilateral Hearing Loss and Auditory Asymmetry in Mitochondrial Disease: A Scoping Review
Authors: Manuelli Marianna , Migliorelli Andrea , Bianchini Chiara , Stomeo Francesco , Pelucchi Stefano , Genovese Elisabetta , Monzani Daniele , Palma Silvia , Ciorba Andrea
Published: August 2024

Background/Objectives: Mitochondrial transfer RNA mutations are one of the most important causes of hereditary hearing loss in humans. In most cases, its presentation is bilateral and symmetrical; however, there are numerous cases of single-sided presentation or asymmetrical onset described in the literature that may represent a diagnostic challenge. The aim of this review is to present the evidence of auditory asymmetry in mitochondrial diseases, highlighting the possible presence of cases with atypical presentation. Methods: A review of the English literature to date on hearing loss and mitochondrial diseases was performed using PubMed, Scopus, and Google Scholar databases. The literature review was performed using the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines for scoping review. Results: A total of 10 full-text articles were included in this review, comprising 25 patients with single-sided or asymmetrical hearing loss associated with mitochondrial disease. Conclusions: Sensorineural hearing loss due to mitochondrial disease can represent a complex diagnostic challenge in cases of asymmetric or unilateral presentation. It is critical to recognize this clinical variant and to diagnose it in daily clinical practice.
GoibhniUWE: A Lightweight and Modular Container-Based Cyber Range
Authors: Mills Alan , White Jonathan , Legg Phil
Published: August 2024

Cyberattacks are rapidly evolving both in terms of techniques and frequency, from low-level attacks through to sophisticated Advanced Persistent Threats (APTs). There is a need to consider how testbed environments such as cyber ranges can be readily deployed to improve the examination of attack characteristics, as well as the assessment of defences. Whilst cyber ranges are not new, they can often be computationally expensive, require an extensive setup and configuration, or may not provide full support for areas such as logging or ongoing learning. In this paper, we propose GoibhniUWE, a container-based cyber range that provides a flexible platform for investigating the full lifecycle of a cyberattack. Adopting a modular approach, users can seamlessly switch out existing, containerised vulnerable services and deploying multiple different services at once, allowing for the creation of complex and realistic deployments. The range is fully instrumented with logging capabilities from a variety of sources including Intrusion Detection Systems (IDSs), service logging, and network traffic captures. To demonstrate the effectiveness of our approach, we deploy the GoibhniUWE range under multiple conditions to simulate various vulnerable environments, reporting on and comparing key metrics such as CPU and memory usage. We simulate complex attacks which span multiple services and networks, with logging at multiple levels, modelling an Advanced Persistent Threat (APT) and their associated Tactics, Techniques, and Procedures (TTPs). We find that even under continuous, active, and targeted deployment, GoibhniUWE averaged a CPU usage of less than 50%, in an environment using four single-core processors, and memory usage of less than 4.5 GB.
Investigating the Dynamic Change and Driving Force of Vegetation Carbon Sink in Taihang Mountain, China
Authors: Qu Qiushi , Jian Sihui , Chen Anguo , Xiao Chiwei
Published: August 2024

Vegetation plays an important role in absorbing carbon dioxide and accelerating the achievement of carbon neutrality. As the ecological barrier of North China, the Taihang Mountains are pivotal to the ecological construction project of China. Nevertheless, the dynamic development of the vegetation carbon sink in the region and the impact factors on the sink have not been systematically evaluated. This study employed a comprehensive approach, utilising remote sensing technology and meteorological and topographic data, in conjunction with the net ecosystem productivity (NEP) estimation model to reveal the characteristics of vegetation carbon sinks in the Taihang Mountain, and then revealed the dynamics evolution of the NEP and the inter-annual trend by using Theil–Sen Median slope estimation, the Mann–Kendall test, and the coefficient of dissociation and analysed the driving roles of the influencing factors by using the parameter optimal geographic detector. Our findings suggest that the NEP in the Taihang Mountain area has a clear growth trend in time, the average value of NEP in the Taihang Mountain area is 289 gC-m−2-a−1 from 2000 to 2022, and the spatial distribution shows the characteristics of high in the northeast and low in the middle and west, with a gradual increase from the northeast to the southwest; the areas with high fluctuation of NEP are mainly distributed in the areas around some cities that are susceptible to the interference of natural or anthropogenic factors. The vegetation carbon sinks in the Taihang Mountains are influenced by a variety of natural factors, among which the explanatory power of each natural factor is as follows: DEM (0.174) > temperature (0.148) > precipitation (0.026) > slope (0.017) > slope direction (0.003). The natural factor DEM had the strongest explanatory power for NEP changes, and the two-by-two effects of the natural factors on vegetation carbon sinks were all significantly stronger than the effects of a single factor, in which the interaction between DEM and precipitation had the strongest explanatory power; distinguishing from climate change factors, the contribution of anthropogenic activities to NEP changes in more than 90% of the area of the Taihang Mountainous Region was more than 60%, and the driving force of anthropogenic factors on NEP changes in the Taihang Mountainous Region was significantly stronger than that of natural climate change. The contribution of anthropogenic factors to NEP changes in the Taihang Mountains was significantly stronger than that of natural climate change. The results of this study can not only provide a reference for carbon reduction and sink increase and ecological restoration projects in the Taihang Mountains but also benefit the research paradigm of vegetation carbon sequestration in other regions.
Water–Energy–Food Nexus in the Yellow River Basin of China under the Influence of Multiple Policies
Authors: Zhang Yikun , Wang Yongsheng
Published: August 2024

The water–energy–food (WEF) nexus constitutes a pivotal aspect of regional ecological protection and high-quality development. The exertion of multiple WEF-related policies would engender both synergies and trade-offs within the WEF nexus. However, a quantified framework that integrates the impact of multiple WEF-related policies with conventional WEF nexus assessments and simulations is currently lacking. This study quantified the WEF nexus in the Yellow River basin (YRB) of China under the influence of multiple policies, calculated the current and future WEF scores under different policy combination scenarios using the improved entropy weight method, the auto-regressive integrated moving average (ARIMA) model, and the linear optimization method. The results revealed the following: (1) From 2000 to 2020, WEF overall scores and subsystem scores were substantially increased with spatial heterogeneity. (2) Scenario analysis indicated that policy implementation would generally accelerate WEF score improvements in each city, yet embracing all policies simultaneously was not optimal for each city. (3) The spatial heterogeneity in policy impacts was also found in the YRB, with higher trade-offs in the upper reaches of cities, and higher synergies in the middle and lower reaches of cities. To attain high-quality development within the YRB, the related policies’ implementation should consider the regional disparities and enhance the optimization of resource allocation across the regions.
Research on Site Selection Planning of Urban Parks Based on POI and Machine Learning—Taking Guangzhou City as an Example
Authors: Tang Xiaoxiang , Zou Cheng , Shu Chang , Zhang Mengqing , Feng Huicheng
Published: August 2024

Against the background of smart city construction and the increasing application of big data in the field of planning, a method is proposed to effectively improve the objectivity, scientificity, and global nature of urban park siting, taking Guangzhou and its current urban park layout as an example. The proposed approach entails integrating POI data and innovatively applying machine learning algorithms to construct a decision tree model to make predictions for urban park siting. The results show that (1) the current layout of urban parks in Guangzhou is significantly imbalanced and has blind zones, and with an expansion of the search radius, the distribution becomes more concentrated; high-density areas decrease from the center outward in a circle, which manifests as a pattern of high aggregation at the core and low dispersion at the edge. (2) Urban park areas with a service pressure of level 3 have the largest coverage and should be prioritized for construction as much as possible; there are fewer areas at levels 4 and 5, which are mainly concentrated in the central city, and unreasonable resource allocation is a problem that needs to be solved urgently. (3) There was a preliminary prediction of 6825 sites suitable for planning, and the fit with existing city parks was 93.7%. The prediction results were reasonable, and the method was feasible. After further screening through the coupling and superposition of the service pressure and the layout status quo, 1537 locations for priority planning were finally obtained. (4) Using the ID3 machine learning algorithm to predict urban park sites is conducive to the development of an overall optimal layout, and subjectivity in site selection can be avoided, providing a methodological reference for the planning and construction of other infrastructure or the optimization of layouts.
Monitoring the Sustainability of the EU Biomass Supply: A Novel Hybrid Approach Combining Tracing and Selected Sustainability Impacts
Authors: Pozo Paola , Bösch Matthias , Schweinle Jörg
Published: August 2024

In an attempt to make a first step toward monitoring the sustainability of wood as (one of) the main element(s) of the EU biomass supply, a novel approach combining a physical accounting model with a material flow–life cycle assessment approach was used to trace the locations of origin of the wood and the associated sustainability impacts. Applying this approach to EU trade data from 2018, we found that around one-third of the wood fiber input in finished paper products consumed in the EU was imported. The main countries of origin were Brazil, the United States and Uruguay. We used Uruguay as a case study of an important country that provides wood pulp to assess the associated sustainability impacts. The results reveal synergies and trade-offs between employment, value added and environmental impacts. We highlight the need to analyze sustainability impacts in different dimensions of sustainability and consider not only territorial impacts in isolation but also from a global perspective in order to have a more holistic overview. Future extensions of the approach could include the coverage of other commodities, additional impacts along the global supply chain (e.g., post-use) and additional sustainability indicators.
A Histological Analysis and Detection of Complement Regulatory Protein CD55 in SARS-CoV-2 Infected Lungs
Authors: Silawal Sandeep , Gögele Clemens , Pelikan Petr , Werner Christian , Levidou Georgia , Mahato Raman , Schulze-Tanzil Gundula
Published: August 2024

Background: A complement imbalance in lung alveolar tissue can play a deteriorating role in COVID-19, leading to acute respiratory distress syndrome (ARDS). CD55 is a transmembrane glycoprotein that inhibits the activation of the complement system at the intermediate cascade level, blocking the activity of the C3 convertase. Objective: In our study, lung specimens from COVID-19 and ARDS-positive COVID+/ARDS+ patients were compared with COVID-19 and ARDS-negative COVID–/ARDS– as well as COVID–/ARDS+ patients. Methods: Histochemical staining and immunolabeling of CD55 protein were performed. Results: The COVID–/ARDS– specimen showed higher expression and homogeneous distribution of glycosaminoglycans as well as compactly arranged elastic and collagen fibers of the alveolar walls in comparison to ARDS-affected lungs. In addition, COVID–/ARDS– lung tissues revealed stronger and homogenously distributed CD55 expression on the alveolar walls in comparison to the disrupted COVID–/ARDS+ lung tissues. Conclusions: Even though the collapse of the alveolar linings and the accumulation of cellular components in the alveolar spaces were characteristic of COVID+/ARDS+ lung tissues, evaluating CD55 expression could be relevant to understand its relation to the disease. Furthermore, targeting CD55 upregulation as a potential therapy could be an option for post-infectious complications of COVID-19 and other inflammatory lung diseases in the future.
The Evaluation of Intrarenal Pressure Using a Novel Single-Use Flexible Ureteroscope with Live Intrarenal Pressure Monitoring—An Experimental Study in Porcine Models
Authors: Samaras Angelos , Tatanis Vasileios , Peteinaris Angelis , Obaidat Mohammed , Faitatziadis Solon , Vagionis Athanasios , Spinos Theodoros , Mylonopoulou Marina , Kallidonis Panagiotis , Liatsikos Evangelos
Published: August 2024

(1) Background: This study aims to evaluate how different irrigation settings and the use of ureteral access sheaths (UASs) of varying sizes impact intrarenal pressure (IRP) during flexible ureteroscopy (fURS) procedures in pigs. (2) Methods: This study utilized three anesthetized female pigs. A novel flexible ureteroscope with the ability to continuously record live intrarenal pressure was used to perform ureteroscopy in different settings. Ureteroscopy was performed without UAS and with the use of 11/13 and 12/14 UAS at the ureteropelvic junction. Two different irrigation methods were employed for each parameter: one using gravity flow and the other using manual pumping with a commercial pump. IRP was also recorded with the presence of a laser fiber or lithotripsy basket. (3) Results: The recorded mean IRP during flexible URS without UAS was 28.25 (±11.2) under gravity irrigation; 35.46 (±10.08) under manual pumping; 22.5 (±3.05) and 30.75 (±5.79) with a laser fiber under gravity irrigation and manual pumping, respectively; and 16.45 (±1.27) and 17.27 (±3.69) with a lithotripsy basket under gravity irrigation and manual pumping, respectively. With an 11/13 UAS, the mean IRP was 15.41 (±8.57) and 19.33 (±4.26) under gravity and manual pumping irrigation, respectively; 14.56 (±2.50) and 18.64 (±5.13) with a laser in each irrigation setting, respectively; and 13.10 (±3.39) and 13.86 (±4.63) with a lithotripsy basket, respectively. With a 12/14 UAS, the mean IRP was 7.64 (±3.08) and 9.25 (±1.42) under gravity and manual pumping irrigation, respectively; 9.50 (±6.04) and 10.28 (3.46), respectively, in each setting when the laser fiber was used; and 5.32 (±1.57) and 6.26 (±1.79), respectively, when the lithotripsy basket was inserted. (4) Conclusion: Novel flexible ureteroscopes with integrated pressure sensors are both a feasible and reliable tool during fURS, giving the surgeon the ability to live-track the IRP. The results of the IRP measurements with and without UAS are in accordance with the current literature and exhibit a consistent pattern with previous studies.
Simulation Model for a Sustainable Food Supply Chain in a Developing Country: A Case Study of the Banana Supply Chain in Malawi
Authors: Moyo Evance Hlekwayo , Carstens Stephen , Walters Jackie
Published: August 2024

Background: Sustainability in food supply chains is desired for production, logistics, and waste management. However, food supply chains (SCs) have complex systems that differ from other SCs. Managing such complexities is challenging for small and medium-sized enterprises (SMEs) due to their heightened constraints, such as limited resources and inadequate awareness. Despite the challenges, there is fragmented research, understanding, and approaches to assist SMEs. SC designs need to be adapted so that SMEs can navigate the challenges and avert high wastage. The main objective of this research was to identify the practices influencing sustainable SC designs in a developing country and create a simulation model to illustrate the potential benefits and challenges of promoting sustainability in the banana SC in Malawi. Methods: Mixed-methods research was utilised, employing a literature review, participant interviews, observations, and survey data collected from 353 participants from three districts in Malawi to gain insight into the banana SC problem, establish objectives, and develop a simulation model complemented by design science research. Results: The research identified awareness, collaboration, efficiency, governance, knowledge sharing, and resilience as sustainability practices in the case study banana SC, thus forming a sustainability model. Simulation results showed improvements in key performance indicators like shelf-life, lead-time, quality, throughput, and waste through SC operation reorganisation. Conclusions: Sustainable models must be tailored to the specific challenges inherent in developing food supply chains in developing nations. The development of the models has significant managerial implications, notably enhancing strategic planning, operational efficiency, risk management, alignment of sustainability goals, performance monitoring, stakeholder engagement, and resource optimisation.
Analyzing Bifurcations and Optimal Control Strategies in SIRS Epidemic Models: Insights from Theory and COVID-19 Data
Authors: Belili Mohamed Cherif , Sahari Mohamed Lamine , Kebiri Omar , Zeghdoudi Halim
Published: August 2024

This study investigates the dynamic behavior of an SIRS epidemic model in discrete time, focusing primarily on mathematical analysis. We identify two equilibrium points, disease-free and endemic, with our main focus on the stability of the endemic state. Using data from the US Department of Health and optimizing the SIRS model, we estimate model parameters and analyze two types of bifurcations: Flip and Transcritical. Bifurcation diagrams and curves are presented, employing the Carcasses method. for the Flip bifurcation and an implicit function approach for the Transcritical bifurcation. Finally, we apply constrained optimal control to the infection and recruitment rates in the discrete SIRS model. Pontryagin’s maximum principle is employed to determine the optimal controls. Utilizing COVID-19 data from the USA, we showcase the effectiveness of the proposed control strategy in mitigating the pandemic’s spread.
Anti-Müllerian Hormone Level Determinants among Non-Polycystic-Ovary-Syndrome Women Undergoing In Vitro Fertilization: A Retrospective Cross-Sectional Study
Authors: Kolcsar Melinda , Szabó László , Mihály Renáta , Vass Erzsébet Rozália , Gáll Zsolt
Published: August 2024

Background and Objectives: The anti-Müllerian hormone (AMH) is a crucial biomarker in regulating ovarian follicle development and female fertility. AMH levels predict ovarian responses in in vitro fertilization (IVF) cycles, helping clinicians tailor treatment strategies. This study aims to determine whether thyroid autoimmunity, age, body mass index (BMI), sexual hormone levels, and 25-hydroxyvitamin D levels influence serum AMH in non-polycystic-ovary-syndrome (PCOS) euthyroid women. Materials and Methods: This retrospective cross-sectional study examined 52 female patients at Zygota Fertility Clinic between 2018 and 2022. Women aged 20–45 years with regular menstrual cycles were included, while conditions such as abnormal thyroid-stimulating hormone (TSH) levels, PCOS, and systemic autoimmune diseases were excluded. A number of parameters were measured in the study, including the subjects’ age, BMI, 25-hydroxyvitamin D, serum free thyroxine (fT4), TSH, various antibodies, and a range of reproductive hormones. An analysis of the relationships between AMH and other variables was conducted using Spearman’s correlation coefficient, and an assessment of the impact of confounding factors on AMH levels was conducted using a multivariable linear regression model. Results: The results revealed significant negative correlations between AMH levels and age (rho: −0.484, p < 0.001) and follicle-stimulating hormone (FSH) (rho: −0.550, p < 0.001), while positive correlations existed between AMH and estradiol (rho: 0.352, p = 0.011) and total testosterone (rho: 0.542, p < 0.001). No significant correlations were found between AMH levels and BMI, LH, or 25-hydroxyvitamin D. Conclusions: In this study, ovarian reserve was influenced by age, estradiol, and total testosterone in non-PCOS euthyroid women undergoing IVF. Conversely, BMI and vitamin D status did not significantly impact AMH levels. In order to better understand and possibly manage ovarian reserve, a holistic approach is absolutely essential, taking into account age, weight, hormonal balance, nutrition, and thyroid health.
An Examination of Temporomandibular Joint Disc Displacement through Magnetic Resonance Imaging by Integrating Artificial Intelligence: Preliminary Findings
Authors: Almășan Oana , Mureșanu Sorana , Hedeșiu Petra , Cotor Andrei , Băciuț Mihaela , Roman Raluca , TEAM Project Group TEAM Project Group
Published: August 2024

Background and Objectives: This research was aimed at constructing a complete automated temporomandibular joint disc position identification system that could assist with magnetic resonance imaging disc displacement diagnosis on oblique sagittal and oblique coronal images. Materials and Methods: The study included fifty subjects with magnetic resonance imaging scans of the temporomandibular joint. Oblique sagittal and coronal sections of the magnetic resonance imaging scans were analyzed. Investigations were performed on the right and left coronal images with a closed mouth, as well as right and left sagittal images with closed and open mouths. Three hundred sagittal and coronal images were employed to train the artificial intelligence algorithm. Results: The accuracy ratio of the completely computerized articular disc identification method was 81%. Conclusions: An automated and accurate evaluation of temporomandibular joint disc position was developed by using both oblique sagittal and oblique coronal magnetic resonance imaging images.
Identifying Early Risk Factors for Postoperative Pulmonary Complications in Cardiac Surgery Patients
Authors: Setlers Kaspars , Jurcenko Anastasija , Arklina Baiba , Zvaigzne Ligita , Sabelnikovs Olegs , Stradins Peteris , Strike Eva
Published: August 2024

Background and Objectives: Postoperative pulmonary complications (PPCs) are common in patients who undergo cardiac surgery and are widely acknowledged as significant contributors to increased morbidity, mortality rates, prolonged hospital stays, and healthcare costs. Clinical manifestations of PPCs can vary from mild to severe symptoms, with different radiological findings and varying incidence. Detecting early signs and identifying influencing factors of PPCs is essential to prevent patients from further complications. Our study aimed to determine the frequency, types, and risk factors significant for each PPC on the first postoperative day. The main goal of this study was to identify the incidence of pleural effusion (right-sided, left-sided, or bilateral), atelectasis, pulmonary edema, and pneumothorax as well as detect specific factors related to its development. Materials and Methods: This study was a retrospective single-center trial. It involved 314 adult patients scheduled for elective open-heart surgery under CPB. Results: Of the 314 patients reviewed, 42% developed PPCs within 12 h post-surgery. Up to 60.6% experienced one PPC, while 35.6% developed two PPCs. Pleural effusion was the most frequently observed complication in 89 patients. Left-sided effusion was the most common, presenting in 45 cases. Regression analysis showed a significant association between left-sided pleural effusion development and moderate hypoalbuminemia. Valve surgery was associated with reduced risk for left-sided effusion. Independent parameters for bilateral effusion include increased urine output and longer ICU stays. Higher BMI was inversely related to the risk of pulmonary edema. Conclusions: At least one PPC developed in almost half of the patients. Left-sided pleural effusion was the most common PPC, with hypoalbuminemia as a risk factor for effusion development. Atelectasis was the second most common. Bilateral effusion was the third most common PPC, significantly related to increased urine output. BMI was an independent risk factor for pulmonary edema development.
A V-Band Wideband Power Amplifier with High Gain in a 130 nm SiGe BiCMOS Process
Authors: Hu Jianing , Wan Jialong , Shen Yi , Zhao Wei , Luo Jiang
Published: August 2024

This paper introduces a high-gain wideband power amplifier (PA) designed for V-band applications, operating across 52 to 65 GHz. The proposed PA design employs a combination of techniques, including pole-gain distribution, base-capacitive peaking, and the parallel configuration of multiple small-sized transistors. These strategies enable significant bandwidth extension while maintaining high gain, substantial output power, and a compact footprint. A two-stage PA using the combination technique was developed and fabricated in a 130 nm SiGe BiCMOS process. The PA prototype achieved a peak gain of 27.3 dB at 64 GHz, with a 3 dB bandwidth exceeding 13 GHz and a fractional bandwidth greater than 22.2%. It delivered a maximum saturated output power of 19.7 dBm and an output 1 dB compression point of 18 dBm. Moreover, the PA chip occupied a total silicon area of 0.57 mm2, including all testing pads with a compact core size of 0.198 mm2.