bluuebunny/crossref_metadata_2025 huggingface dataset:
Safety and Activity of Metronomic Temozolomide in Second-Line Treatment of Advanced Neuroendocrine Neoplasms
Authors: Tafuto Salvatore , von Arx Claudia , Capozzi Monica , Tatangelo Fabiana , Mura Manuela , Modica Roberta , Barretta Maria Luisa , Di Sarno Antonella , Tornesello Maria Lina , Colao Annamaria , Ottaiano Alessandro
Published: August 2019

Background. Platinum-based chemotherapy is the mainstay of front-line treatment of patients affected by pluri-metastatic intermediate/high grade NeuroEndocrine Neoplasms (NENs). However, there are no standard second-line treatments at disease progression. Previous clinical experiences have evidenced that temozolomide (TMZ), an oral analog of dacarbazine, is active against NENs at standard doses of 150 to 200 mg/mq per day on days 1 to 5 of a 28-day cycle, even if a significant treatment-related toxicity is reported. Methods. Metastatic NENs patients were treated at the ENETS (European NeuroEndocrine Tumor Society) center of excellence of Naples (Italy), from 2014 to 2017 with a second-line alternative metronomic schedule of TMZ, 75 mg/m2 per os “one week on/one week off”. Toxicity was graded with NCI-CTC criteria v4.0; objective responses with RECIST v1.1 and performance status (PS) according to ECOG. Results. Twenty-six consecutive patients were treated. Median age was 65.5 years. The predominant primary organs were pancreas and lung. Grading was G2 in 11 patients, G3 in 15. More than half of patients had a PS 2 (15 vs. 11 with PS 1). The median time-on-temozolomide therapy was 12.2 months (95% CI: 11.4–19.6). No G3/G4 toxicities were registered. Complete response was obtained in 1 patient, partial response in 4, stable disease in 19 (disease control rate: 92.3%), and progressive disease in 2. The median overall survival from TMZ start was 28.3 months. PS improved in 73% of patients. Conclusions. Metronomic TMZ is a suitable treatment for G2 and G3 NENs particularly in PS 2 patients. Prospective and larger trials are needed to confirm these results.
Relationship between HDL Cholesterol Efflux Capacity, Calcium Coronary Artery Content, and Antibodies against ApolipoproteinA-1 in Obese and Healthy Subjects
Authors: Vuilleumier Nicolas , Pagano Sabrina , Montecucco Fabrizio , Quercioli Alessandra , Schindler Thomas H. , Mach François , Cipollari Eleonora , Ronda Nicoletta , Favari Elda
Published: August 2019

Aims: To explore the associations between cholesterol efflux capacity (CEC), coronary artery calcium (CAC) score, Framingham risk score (FRS), and antibodies against apolipoproteinA-1 (anti-apoA-1 IgG) in healthy and obese subjects (OS). Methods and Results: ABCA1-, ABCG1-, passive diffusion (PD)-CEC and anti-apoA-1 IgG were measured in sera from 34 controls and 35 OS who underwent CAC score determination by chest computed tomography. Anti-apoA-1 IgG ability to modulate CEC and macrophage cholesterol content (MCC) was tested in vitro. Controls and OS displayed similar ABCG1-, ABCA1-, PD-CEC, CAC and FRS scores. Logistic regression analyses indicated that FRS was the only significant predictor of CAC lesion. Overall, anti-apoA-1 IgG were significantly correlated with ABCA1-CEC (r = 0.48, p < 0.0001), PD-CEC (r = −0.33, p = 0.004), and the CAC score (r = 0.37, p = 0.03). ABCA1-CEC was correlated with CAC score (r = 0.47, p = 0.004) and FRS (r = 0.18, p = 0.29), while PD-CEC was inversely associated with the same parameters (CAC: r = −0.46, p = 0.006; FRS: score r = −0.40, p = 0.01). None of these associations was replicated in healthy controls or after excluding anti-apoA-1 IgG seropositive subjects. In vitro, anti-apoA-1 IgG inhibited PD-CEC (p < 0.0001), increased ABCA1-CEC (p < 0.0001), and increased MCC (p < 0.0001). Conclusions: We report a paradoxical positive association between ABCA1-CEC and the CAC score, with the latter being inversely associated with PD in OS. Corroborating our clinical observations, anti-apoA-1 IgG enhanced ABCA1 while repressing PD-CEC, leading to MCC increase in vitro. These results indicate that anti-apoA-1 IgG have the potential to interfere with CEC and macrophage lipid metabolism, and may underpin paradoxical associations between ABCA1-CEC and cardiovascular risk.
Long-Term Neurodevelopmental Outcome in Twin-to-Twin Transfusion Syndrome: Is there still Room for Improvement?
Authors: Spruijt Marjolijn S. , Lopriore Enrico , Tan Ratna N.G.B. , Slaghekke Femke , Klumper Frans J.C.M. , Middeldorp Johanna M. , Haak Monique C. , Oepkes Dick , Rijken Monique , van Klink Jeanine M.M.
Published: August 2019

Despite many developments in its management, twin-to-twin transfusion syndrome (TTTS) remains an important risk factor for long-term neurodevelopmental impairment (NDI). Our objective was to compare the incidence of severe NDI in a recent cohort of TTTS survivors, treated with laser surgery from 2011 to 2014, with a previous cohort treated from 2008 to 2010. Neurological, cognitive, and motor development were assessed at two years of age. We determined risk factors associated with Bayley-III scores. Severe NDI occurred in 7/241 (3%) survivors in the new cohort compared to 10/169 (6%) in the previous cohort (p = 0.189). Disease-free survival (survival without severe impairment) did not significantly differ. Low birth weight and being small for gestational age (SGA) were independently associated with lower cognitive scores (both p < 0.01). Severe cerebral injury was related to decreased motor scores (B = −14.10; 95% CI −3.16, −25.04; p = 0.012). Children with severe NDI were born ≥32 weeks’ gestation in 53% of cases and had no evidence of cerebral injury on cranial ultrasound in 59% of cases. Our results suggest that improvement in outcome of TTTS has reached a plateau. Low birth weight, SGA, and cerebral injury are risk factors for poor neurodevelopmental outcome. Neither gestational age above 32 weeks nor the absence of cerebral injury preclude severe NDI.
Dry Eye Disease: A Review of Epidemiology in Taiwan, and its Clinical Treatment and Merits
Authors: Kuo Yu-Kai , Lin I-Chan , Chien Li-Nien , Lin Tzu-Yu , How Ying-Ting , Chen Ko-Hua , Dusting Gregory J. , Tseng Ching-Li
Published: August 2019

Dry eye disease (DED) has become common on a global scale in recent years. There is a wide prevalence of DED in different countries based on various ethnicities and environment. DED is a multifactorial ocular disorder. In addition to advanced age and gender, such factors as living at high altitude, smoking, pterygium, prolonged use of consumer electronics or overingesting of caffeine or multivitamins are considered to be the major risk factors of DED. We report the DED epidemiology in Taiwan firstly in this article. According to the pathophysiological factors and changes inthe composition of the tear film in DED, it can be categorized into several subtypes, including lipid anomaly dry eye, aqueous tear deficiency, allergic and toxic dry eye among others. Each subtype has its own cause and disease management; therefore, it is important for ophthalmologists to identify the type through literature review and investigation. The management of DED, relies not only on traditional medications such as artificial tears, gels and ointments, but also newer treatment options such as acupuncture, SYL1001, and nanomedicine therapy. We also conducted a comprehensive literature review including common subtypes and treatment of DED. Clearly, more clinical trials are needed to assess the efficacy and safety of the various treatments and common subtypes of DED.
The Relationship between Metabolically Healthy Obesity and the Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis
Authors: Yeh Tzu-Lin , Chen Hsin-Hao , Tsai Szu-Ying , Lin Chien-Yu , Liu Shu-Jung , Chien Kuo-Liong
Published: August 2019

Cardiovascular disease (CVD) risk in individuals with metabolically healthy obesity (MHO) is unclear. We searched databases from inception to May 2019. Data were pooled using a random effects model. Newcastle-Ottawa Scale assessment was performed. Primary and secondary outcomes were CVD risk and all-cause mortality. Forty-three studies involving 4,822,205 cases were included. The median percentage of females, age and duration of follow-up was 52%, 49.9 years and 10.6 years, respectively. The mean Newcastle-Ottawa Scale score of the articles was 7.9 ± 1.0. Compared to individuals with a metabolically healthy normal weight, individuals with MHO had higher adjusted risk of CVD and all-cause mortality. We identified a significant linear dose-response relationship between body mass index (BMI) and CVD risk among metabolically healthy individuals (p < 0.001); every unit increase in BMI increased the CVD risk. Multivariate meta-regression analysis showed that an increased proportion of women and age resulted in the risk of CVD affected by MHO reduction (p = 0.014, p = 0.030, respectively). Age and sex explained the observed heterogeneity and reported the adjusted R2. MHO resulted in a significantly increased risk for CVD; therefore, long-term weight loss should be encouraged.
Implementation of Electrical Auricular Acupuncture and Low Frequency Modulated Electric Current Therapy in Pain Management of Patients with Knee Osteoarthritis: A Randomized Pilot Trial
Authors: Krusche-Mandl Irena , Kaider Alexandra , Starlinger Julia , Preschitz Michael , Schuster Rupert , Kefurt Ronald , Marhofer Peter , Kasparek Maximilian , Hajdu Stefan , Sator-Katzenschlager Sabine
Published: August 2019

Background: Knee osteoarthritis is a major cause of knee pain. Conservative therapy resources are limited due to adverse effects. Therefore, alternative non-invasive therapy approaches to reduce pain medications are gaining importance. The current study analyses if electrical auricular acupuncture (EAA) or low frequency modulated electric current therapy (LFMECT) could support analgesic treatment. Methods: In a randomized pilot trial patients with painful knee OA were treated with EAA (group 1) or LFMECT (group 2) additional to standard pharmacological analgesic treatment. In total 19 female and 10 male patients with a mean age of 59.1 years (standard deviation ± 13.6) and a mean BMI of 28.9 kg/m2 (± 5.2) were included. Patients were randomly assigned to one of the groups stratified for age, gender and BMI. Before starting of the active study period and collecting of the initial data on day 1, all patients received a pharmacological analgesic baseline therapy for one week. At the next study stage patients started their randomly assigned treatment protocol for 42 days and final follow-up was set on day 70. Patients recorded their pain intensity (numerical rating scale; NRS) using a standardized patient diary. The pain free walking time in min was recorded and range of motion was assessed. Results: Rescue medication intake was comparable between both groups on day 42 (p = 0.55) and day 70 (p = 0.35). After the active study period (day 42) pain scores decreased significantly in both groups (group 1 p = 0.02; group 2 p = 0.0006). At follow up median pain scores further decreased in group 1 (p = 0.0002) and remained at a low level in group 2 (p = 0.001). Level of pain decreased in about 50% in both groups and was comparable during the study period. Total mean range of motion (ROM) increased in both groups (group 1 p = 0.0003; group 2 p = 0.02). Group 1 had more improvement of mean total ROM compared to group 2 (p = 0.034). Pain-free walking time increased in both groups and was comparable between both groups (p = 0.31). Any adverse effects due to EAA or LFMECT were not observed. Conclusions: Data of the current study indicates that implementation of EAA or LFMECT seems to be beneficial to reduce knee pain and improve knee function in patients with knee osteoarthritis.
The Combination of Different Ergonomic Supports during Dental Procedures Reduces the Muscle Activity of the Neck and Shoulder
Authors: García-Vidal José A. , López-Nicolás Manuel , Sánchez-Sobrado Ana C. , Escolar-Reina María P. , Medina-Mirapeix Francesc , Bernabeu-Mora Roberto
Published: August 2019

Ergonomic supports have become popular for the prevention of musculoskeletal disorders. This study sought to evaluate the efficacy of different ergonomic supports and their combination to reduce muscle activity of the neck and shoulder muscles. A one-way repeated measures design was used to evaluate 36 practicing dentists while they performed three posterior composite restoration procedures on a phantom head. Portable surface electromyography (sEMG) recordings were used to measure the muscle activity of three muscles (Upper Trapezius, Lateral Deltoid and Anterior Deltoid) in the dominant upper extremity, with and without the use of different ergonomic supports (ergonomic stool, magnification lenses and both) during the performance of these tasks. A repeated measures analysis of variance was used. The muscle activity of all muscles differed significantly across the four ergonomic conditions during the three tasks. The use of ergonomic supports such as magnification lenses, the ergonomic stool, or the combination of both, is effective for decreasing the muscle activity of the three muscles during the three tasks, when compared to standard practice. In addition, the decrease of muscle activity was higher using magnification lenses when compared to the ergonomic stool. Furthermore, the greatest decrease was found with the combination of both supports.
Hypoxia Rapidly Induces the Expression of Cardiomyogenic Factors in Human Adipose-Derived Adherent Stromal Cells
Authors: Choi Jung-Won , Moon Hanbyeol , Jung Seung , Lim Soyeon , Lee Seahyoung , Kim Il-Kwon , Lee Hoon-Bum , Lee Jiyun , Song Byeong-Wook , Kim Sang , Hwang Ki-Chul
Published: August 2019

Background: The efficacy of interstitial vascular fraction (SVF) transplantation in the treatment of heart disease has been proven in a variety of in vivo studies. In a previous study, we found that bone marrow-derived mesenchymal stem cells (BM-MSCs) altered their expression of several cardiomyogenic factors under hypoxic conditions. Methods: We hypothesized that hypoxia may also induce obtained adipose-derived adherent stromal cells (ADASs) from SVFs and adipose-derived stem cells (ASCs) to differentiate into cardiomyocytes and/or cells with comparable phenotypes. We examined the differentiation markers of cell lineages in ADASs and ASCs according to time by hypoxic stress and found that only ADASs expressed cardiomyogenic markers within 24 h under hypoxic conditions in association with the expression of hypoxia-inducible factor 1-α (HIF-1α). Results: Differentially secreted proteins in a conditioned medium (CM) from ASCs and ADASs under normoxic or hypoxic conditions were detected using an antibody assay and may be associated with a dramatic increase in the expression of cardiomyogenic markers in only ADASs. Furthermore, the cardiomyogenic factors were expressed more rapidly in ADASs than in ASCs under hypoxic conditions in association with the expression of HIF-1α, and angiogenin, fibroblast growth factor-19 (FGF-19) and/or macrophage inhibitory factor (MIF) are related. Conclusions: These results provide new insights into the applicability of ADASs preconditioned by hypoxic stress in cardiac diseases.
Sport Intervention Programs (SIPs) to Improve Health and Social Inclusion in People with Intellectual Disabilities: A Systematic Review
Authors: Scifo Lidia , Chicau Borrego Carla , Monteiro Diogo , Matosic Doris , Feka Kaltrina , Bianco Antonino , Alesi Marianna
Published: August 2019

Inactivity is a major issue that causes physical and psychological health problems, especially in people with intellectual disability (ID). This review discusses the beneficial effects of sport intervention programs (SIPs) in people with ID, and aims to provide an overview of the scientific literature in order to identify the main factors influencing the participation of people with ID in SIPs. Twelve papers were analyzed and compared. The results show a large variety in examined SIPs, concerning participants’ age and disability, intervention characteristics and context, as well as measures and findings. The main factors essential for people with ID partaking in SIPs appeared to be suitable places for the SIP development, adequate implementation of physical activity (PA) programs in school and extra-school contexts, education, and the training of teachers and instructors. The literature review highlights the relevance of using SIPs in order to improve physical and psychological health, as well as increase social inclusion in populations with ID. SIPs should be included in multifactor intervention programs. Nevertheless, the need is recognized for stakeholders to adopt specific practice and policy in promoting social inclusion in order to organize intervention strategies which are able to provide quality experiences in sport and physical activity for people with ID.
Influence of Magnesium on Spatter Behavior in Laser Deep Penetration Welding of Aluminum Alloys
Authors: Felsing Andreas , Woizeschke Peer
Published: August 2019

The quality of welds, as well as the necessity of post-processing, is challenged by spatter generation during the laser keyhole welding process. In this study, the influence of the magnesium content on spatter behavior is studied for three aluminum alloys (Al99.5, AlMg3, and AlMg5). A synchronized dual high-speed camera system is used to observe the spatter behavior and to reconstruct 3D spatter trajectories as well as determine the characteristics of spatter velocity, flight path angle, and approximate spatter size. The mean spatter velocities and flight path angles of the welding experiments with the three alloys were in welding direction between 4.1 m/s and 4.6 m/s and 44.8° and 51.0°, respectively. Furthermore, the AlMg alloys show excessive spatter behavior with spray events of more than 50 spatters at a time, and less frequently spatter explosions. Spatter spray events show a character similar to spatter explosions. Volumetric evaporation is proposed as effecting these events. In contrast, and resulting from a different mechanism, pure aluminum (Al99.5) shows group ejection events with at least 10 spatters at a time. In this study, there are no correlations between spatter velocities and flight path angles, nor between velocities and approximate spatter sizes.
Trends in the Recent Evolution of Coastal Lagoons and Lakes in Galicia (NW Iberian Peninsula)
Authors: Fraga-Santiago Pedro , Gómez-Pazo Alejandro , Pérez-Alberti Augusto , Montero Pablo , Otero Pérez Xose Lois
Published: August 2019

Coastal lagoons are habitats of great environmental value. However, they are currently subject to major threats, particularly due to increasing sea levels. This study aims to identify changes—both natural and induced by anthropic activity—and their impact on the recent evolution of three different types of coastal lagoons in Galicia (Louro, Vixán, and Xuño). The application of information obtained through laser imaging detection and ranging (LiDAR) techniques suggests that the outer limits of the three lagoon systems have not experienced any relevant changes in the last 60 years (i.e., no occupation of the lagoon area has been identified). However, the internal configuration of these wetland areas has experienced some alterations. A generalized increase in the area occupied by macrophytic communities (Phragmites australis, Scirpus maritimus, Juncus maritimus, etc.) has been observed. Image interpretation by geographic information systems (GIS) and field surveys suggest that the area currently occupied by macrophytes experienced a 7% to 63% increase at the expense of the free water body. This loss of flooded area is consistent with the increase in sedimentation rates associated with the convergence of several causes, such as the abandonment of traditional macrophyte biomass harvesting and agricultural activities around the lagoons, the expansion of riparian forests, and sediment contributions by erosion due to recurrent forest fires within the drainage basins of each lagoon. Finally, water and sediment composition suggest that, of the three studied lagoons, two of them (Louro and Vixán) are included within the definition of “coastal lagoons” (habitat code 1150) by the Habitats Directive (Directive 92/43/EEC), while the Xuño lagoon should be considered a “natural eutrophic lake” (habitat code 3150).
Numerical Simulation of Vacuum Preloading for Reinforcing Soil inside Composite Bucket Foundation for Offshore Wind Turbines
Authors: Ding Hongyan , Peng Yanjian , Zhang Puyang , Nie Liyun , Zhai Hanbo
Published: August 2019

The composite bucket foundation (CBF) with seven honeycomb subdivisions is a new foundation for offshore wind turbine structures. The bearing capacity of CBF can be improved by consolidation of soil inside the CBF, which is caused by the vacuum preloading method after installation. A three-dimensional numerical model is established to simulate the consolidation process of soil for CBF with and without subdivisions in terms of vertical settlement, pore water pressure and void ratio of the soil. This analysis investigates the reinforcement effect of the two foundation types to assess the influence of the bulkheads. The results obtained show that there are obvious reinforcement effects for both foundation types. In the early stage of consolidation, vertical settlement is rapid, and this becomes stable with time. The depth at which the pore water pressure becomes negative is the depth showing the main reinforcement. Vacuum pressure decreases continuously with increase in soil depth and time. In addition, the excess pore water pressure in the soil dissipates, which turns into the soil effective stress. Bulkheads provide vertical drainage channels in the soil and shorten the seepage path, allowing the extraction of more pore water. This is conducive to the improvement of shallow soil, while also decreasing the extraction of pore water in deep soil and the region of the soil that can be reinforced.
Questioning Segregation of People Living with Dementia in Australia: An International Human Rights Approach to Care Homes
Authors: Steele Linda , Swaffer Kate , Phillipson Lyn , Fleming Richard
Published: August 2019

This article explores how care homes—and, specifically, their common features such as dementia care units and locked doors and gates—impact on the human rights of people living with dementia. We suggest that congregation, separation and confinement of people living with dementia by the care home built environment constitute ‘segregation’. In the specific context of residential aged care facilities in Australia, we draw on the United Nations Convention on the Rights of Persons with Disabilities (‘CRPD’) to frame this segregation as an injustice. We focus on the rights to non-discrimination (Article 5), liberty and security of the person (Article 14), equality before the law (Article 12), accessibility (Article 9), and independent living and community inclusion (Article 19). Our analysis shows that addressing segregation must involve structural and resource reforms that are transformative in bringing about new ways of living and relating to each other. Such reforms are directed towards providing meaningful alternatives and appropriate supports to make choices from a range of alternative residency and support options, and building communities that are free from ableism, ageism and other systems of oppression that contribute to confinement and segregation.
The Effects of Sintering Temperature and Addition of TiH2 on the Sintering Process of Cu
Authors: Hao Huali , Wang Yanjing , Jafari Nodooshan Hamid Reza , Zhang Yongyun , Ye Shulong , Lv Yonghu , Yu Peng
Published: August 2019

In this study, effects of sintering temperature and TiH2 on the sintering process of Cu are investigated. During sintering, the oxide in Cu decomposes and generates oxygen, which can become trapped in the material forming closed pores. Therefore, this results in low sintered density. Sintering behavior of Cu can be significantly improved by adding 0.5 wt.% TiH2 which decomposes during sintering, producing hydrogen and effectively reducing the oxide in Cu. Although gas products of the reduction reaction may still be trapped inside the close pores formed near the TiH2 particles and handicap the sintering of Cu, an isothermal treatment at 650 °C can avoid forming close pores. This allows reaction products to dissipate freely from the sample, subsequently increasing its sintered density.
Study on the Thermal Conductivity Characteristics for Ultra-Thin Body FD SOI MOSFETs Based on Phonon Scattering Mechanisms
Authors: Zhang Guohe , Lai Junhua , Su Yali , Li Binhong , Li Bo , Bu Jianhui , Yang Cheng-Fu
Published: August 2019

The silicon-on-insulator (SOI) metal-oxide-semiconductor field-effect transistors (MOSFETs) suffer intensive self-heating effects due to the reduced thermal conductivity of the silicon layer while the feature sizes of devices scale down to the nanometer regime. In this work, analytical models of thermal conductivity considering the self-heating effect (SHE) in ultra-thin body fully depleted (UTB-FD) SOI MOSFETs are presented to investigate the influences of impurity, free and bound electrons, and boundary reflection effects on heat diffusion mechanisms. The thermal conductivities of thin silicon films with different parameters, including temperature, depth, thickness and doping concentration, are discussed in detail. The results show that the thermal dissipation associated with the impurity, the free and bound electrons, and especially the boundary reflection effects varying with position due to phonon scattering, greatly suppressed the heat loss ability of the nanoscale ultra-thin silicon film. The predictive power of the thermal conductivity model is enhanced for devices with sub-10-nm thickness and a heavily doped silicon layer while considering the boundary scattering contribution. The absence of the impurity, the electron or the boundary scattering leads to the unreliability in the model prediction with a small coefficient of determination.
Global Stability of Fractional Order Coupled Systems with Impulses via a Graphic Approach
Authors: Zhang Bei , Xia Yonghui , Zhu Lijuan , Liu Haidong , Gu Longfei
Published: August 2019

Based on the graph theory and stability theory of dynamical system, this paper studies the stability of the trivial solution of a coupled fractional-order system. Some sufficient conditions are obtained to guarantee the global stability of the trivial solution. Finally, a comparison between fractional-order system and integer-order system ends the paper.
The Protective Effect of Mycosporine-Like Amino Acids (MAAs) from Porphyra yezoensis in a Mouse Model of UV Irradiation-Induced Photoaging
Authors: Ying Rui , Zhang Zhaohui , Zhu Huiying , Li Bafang , Hou Hu
Published: August 2019

The objective of this research was to extract and prepare mycosporine-like amino acids (MAAs) and investigate the mechanism by which they act against UV-induced skin photoaging in Institute of Cancer Research (ICR ) mice. MAAs such as porphyra-334 and shinorine were extracted from Porphyra yezoensis, separated, and purified using column chromatography with SA-2 cation exchange resin. The effects of MAAs on the activity of endogenous antioxidant enzymes, namely total superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and malondialdehyde (MDA) were analyzed in mouse skin tissue. Pathological changes of skin tissue caused by ultraviolet radiation and the arrangement of collagen were observed by Hematoxylin-Eosin (HE) staining and scanning electron microscopy (SEM). Interleukin 1β (IL-1β), IL-6, and IL-10 were detected using the quantitative real-time reverse transcription-polymerase chain reaction (qPCR) and Enzyme Linked Immunosorbent Assay (ELISA). The concentration and expression of these proinflammatory cytokines was associated with the presence of nuclear factor (NF)-κB. The results show that MAA compounds from Porphyra yezoensis could suppress UV-induced photoaging of skin by inhibiting the reduction of endogenous antioxidant enzymes. Compared to the control group, the concentrations of SOD, GSH-Px, and CAT increased significantly in skin tissue homogenate following the external administration of MAAs (p < 0.05, p < 0.01), while the content of MDA decreased significantly (p < 0.05). Meanwhile, the administration of MAAs was associated with down-regulations in the concentration and mRNA expression of NF-κB, IL-1β, IL-6, and IL-10. The results suggest that MAAs could protect skin from photodamage by increasing antioxidant enzyme activities and inhibiting inflammation.
Irisin as a Multifunctional Protein: Implications for Health and Certain Diseases
Authors: Korta Paulina , Pocheć Ewa , Mazur-Biały Agnieszka
Published: August 2019

Sedentary life style is considered to be an independent risk factor for many disorders, including development of type 2 diabetes, obesity, immune dysfunction, asthma, and neurological or coronary heart disease. Irisin is released from myocytes during physical activity, and acts as a link between muscles and other tissues and organs. This myokine is produced as a result of proteolytic cleavage of FNDC5 protein present in the membrane of myocytes. Secretion of irisin is regulated by N-linked oligosaccharides attached to the protein molecule. The two N-glycan molecules, which constitute a significant part of the irisin glycoprotein, regulate the browning of adipocytes, which is the most important function of irisin. A receptor specific for irisin has still not been discovered. In some tissues irisin probably acts via integrins, which are widely expressed transmembrane receptors. Many studies have confirmed the multifunctional role of irisin and the beneficial effects of this molecule on body homeostasis. Irisin reduces systemic inflammation, maintains the balance between resorption and bone formation, and modulates metabolic processes and the functioning of the nervous system. It suppresses the expression and release of pro-inflammatory cytokines in obese individuals and attenuates inflammation in adipose tissue. The impact of irisin on cancer cell proliferation, migration, and invasion has also been demonstrated in numerous studies, which proves its role in carcinogenesis. Owing to these pleiotropic and beneficial properties, irisin may be a potential option to prevent and treat civilization-related diseases which are, nowadays, considered to be the major health problems in Western societies.
Relationship between Children’s Birth Weight and Birth Length and a Risk of Overweight and Obesity in 4–15-Year-Old Children
Authors: Baran Joanna , Weres Aneta , Czenczek-Lewandowska Ewelina , Leszczak Justyna , Kalandyk-Osinko Katarzyna , Mazur Artur
Published: August 2019

Background and Objectives. The purpose of the study was to investigate the relationship between children’s birth weight/length and a risk of overweight and obesity. Materials and Methods. The study involved 747 children from kindergartens, as well as primary and middle schools from southeastern Poland. All the subjects were examined on fasting status. Each child was examined for body mass and height, in order to calculate their body mass index (BMI), and BMI centile. The parents completed a questionnaire related to basic information about the child and the family. Results. In the study group, the male infants presented greater birth body weight and birth body length. A comparison of the distribution of birth weights and lengths between the children with normal BMI and with high BMI showed statistically significant differences only in the case of birth length of 12–15-year-old children and in the group of boys aged 12–15 years. In the case of the female children and the group of 7–11-year-olds a statistically significant difference was found in the BMI centile at a later age—a higher centile was found in the girls and in the children aged 7–11 years classified as adequate for gestational age (AGA). Conclusions. Birth body weight is positively related to BMI centile; however, no significant differences were found in birth weight between children with overweight/obesity and children with normal body weight. Birth length is associated with a lower BMI centile only in boys aged 12–15 years, and lower birth length is found in boys with overweight and obesity.
Four Cases of Perineal Groove—Experience of a Greek Maternity Hospital
Authors: Boutsikou Theodora , Mougiou Vasiliki , Sokou Rozeta , Kollia Maria , Kafalidis George , Iliodromiti Zoi , Salakos Christos , Iacovidou Nicoletta
Published: August 2019

Perineal groove is a well-defined clinical entity that belongs to a broader group of anorectal malformations. It is characterized by a non-epithelialized mucous membrane that appears as an erythematous sulcus in the perineal midline, extending from the posterior vaginal fourchette to the anterior anal orifice. The defect is gradually cicatrized, unless there are complications like infection, defecation disorders, trauma, and bleeding. The differential diagnosis includes several other conditions like trauma, infection, irritant dermatitis, lichen sclerosis, and ulcerated hemangioma. Since it is a rare malformation, it is often misdiagnosed and its presence often elicits unnecessary diagnostic workup and intervention. In this respect, neonatologists, dermatologists, or pediatric surgeons may under- or overestimate it. We report four cases of perineal groove out of 2250 live births at a Greek Maternity Hospital between September 2016 and April 2019. The “high” incidence of perineal groove cases in our Department allowed us to familiarize with this rare defect and minimize our clinical interventions.
Serum Levels of Carbamylated LDL and Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Are Associated with Coronary Artery Disease in Patients with Metabolic Syndrome
Authors: Stankova Teodora , Delcheva Ginka , Maneva Ana , Vladeva Stefka
Published: August 2019

Background and objectives: Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) has been recognized as the primary receptor for carbamylated low-density lipoproteins (cLDL) and is increasingly being viewed as a critical mediator of vascular inflammation and atherosclerosis. The aim of the current study was to evaluate the possible role of circulating cLDL and soluble LOX-1 (sLOX-1) as potential biomarkers of metabolic syndrome (MetS) as well as of coronary artery disease (CAD) among MetS patients. Materials and Methods: The serum levels of cLDL and sLOX-1 were measured by ELISA in 30 MetS patients without CAD, 30 MetS patients with CAD, and 30 healthy controls. Results: Patients with MetS had significantly higher serum levels of both cLDL and sLOX-1 than the healthy controls but lower in comparison to MetS + CAD subjects. Serum sLOX-1 concentration correlated significantly with fasting glucose (rs = 0.414, p = 0.001) and high-density lipoprotein (HDL)-cholesterol (rs = −0.273, p = 0.035) in the whole MetS cohort, whereas it correlated with cLDL only in the MetS + CAD subgroup (rs = 0.396, p = 0.030). The receiver-operating characteristic (ROC) curves of cLDL and sLOX-1 for MetS diagnosis had area under the curve (AUC) values of 0.761 and 0.692, respectively. AUC values of cLDL and sLOX-1 for CAD diagnosis among MetS patients were 0.811 and 0.739. Elevated serum levels of cLDL and sLOX-1 were associated with a higher risk of MetS development [odds ratio (OR) 24.28, 95% confidence interval (CI): 5.86–104.61, p < 0.001 and OR 4.75; 95% CI: 1.58–14.25, p = 0.009] as well as with presence of CAD among MetS subjects (OR 11.23; 95% CI: 3.10–40.71, p < 0.001 and OR 4.03; 95% CI: 1.73–11.84, p = 0.019, respectively). Conclusions: The present study underscores the potential of cLDL and sLOX-1 as promising biomarkers for diagnosis and risk assessment of MetS and CAD among the MetS population.
Role of Cellulose Micro and Nano Crystals in Thin Film and Support Layer of Nanocomposite Membranes for Brackish Water Desalination
Authors: Kadhom Mohammed , Albayati Noor , Salih Suhaib , Al-Furaiji Mustafa , Bayati Mohamed , Deng Baolin
Published: August 2019

Reverse osmosis is a major process that produces soft water from saline water, and its output represents the majority of the overall desalination plants production. Developing efficient membranes for this process is the aim of many research groups and companies. In this work, we studied the effect of adding cellulose micro crystals (CMCs) and cellulose nano crystals (CNCs) to the support layer and thin film nanocomposite (TFN) membrane on the desalination performance. SEM, TEM, ATR-FTIR, and contact angle measurements were used to characterize the membrane’s properties; and membrane’s performance were evaluated by water flux and NaCl rejection. Filling 2% of CNCs gel in the support layer improved the water flux by +40%, while salt rejection maintained almost the same, around 95%. However, no remarkable improvement was gained by adding CNCs gel to m-phenylenediamine (MPD) solution, which was used in TFN membrane preparation. Filling CMCs powder in TFN membrane led to a slight improvement in terms of water flux.
Mixing Phenomenon and Flow Field in Ladle of RH Process
Authors: Zhang Kaitian , Cui Heng , Wang Rudong , Liu Yang
Published: August 2019

Particle image velocimetry (PIV) system was adopted to investigate the relationship between the mixing phenomenon and the flow field of a 210 t RH degasser by a 1:4 scale water model. The results of mixing simulation experiments indicated that the mixing time decreased with the increase of gas blowing rate. However, with the increase of Snorkel immersion depth (SID), the mixing time presented a decreasing rend firstly and then increased. The measurement of flow fields of RH ladle by PIV system can explain the phenomenon above. According to the characteristics of the flow field in RH ladle, the flow field can be divided into the mixing layer, the transition layer, and the inactive layer. On the one hand, the stirring power in RH ladle and vacuum chamber both increases with more gas blowing rate, leading to the decrease of mixing time. On the other hand, with SID increases from 400 mm to 480 mm, the gas blowing depth increase results in the mixing power increases, and the mixing time decreases at the beginning. Because of too much-molten steel in the vacuum chamber and the expanding of the inactive layer in RH ladle, however, the utilization rate of the gas driving force begins to decrease. Therefore, the mixing time started to increases with the increase of SID.
Microstructure and Mechanical Properties of Nb and V Microalloyed TRIP-Assisted Steels
Authors: Oja Olli , Saastamoinen Ari , Patnamsetty Madan , Honkanen Mari , Peura Pasi , Järvenpää Martti
Published: August 2019

The intercritical annealing and isothermal bainitic processing response was studied for three Nb and V microalloyed Transformation-Induced Plasticity (TRIP)-assisted 980 MPa grade steels. Their mechanical and microstructural properties were compared to industrially produced TRIP 800 steel. Depending on the isothermal holding temperature and microalloying, the experimental steels reached properties comparable to the reference steel. The retained austenite content did not show direct correlation to elongation properties. Niobium was found to be more effective microalloying element than vanadium in increasing the elongation properties, which were investigated by measuring true fracture strain from tensile test specimens.
Environmental Behavior of Low Carbon Steel Produced by a Wire Arc Additive Manufacturing Process
Authors: Ron Tomer , Levy Galit Katarivas , Dolev Ohad , Leon Avi , Shirizly Amnon , Aghion Eli
Published: August 2019

Current additive manufacturing (AM) processes are mainly focused on powder bed technologies, such as electron beam melting (EBM) and selective laser melting (SLM). However, the main disadvantages of such techniques are related to the high cost of metal powder, the degree of energy consumption, and the sizes of the components, that are limited by the size of the printing cell. The aim of the present study was to evaluate the environmental behavior of low carbon steel (ER70S-6) produced by a relatively inexpensive AM process using wire feed arc welding. The mechanical properties were examined by tension testing and hardness measurements, while microstructure was assessed by scanning electron microscopy and X-ray diffraction analysis. General corrosion performance was evaluated by salt spray testing, immersion testing, potentiodynamic polarization analysis, and electrochemical impedance spectroscopy. Stress corrosion performance was characterized in terms of slow strain rate testing (SSRT). All corrosion tests were carried out in 3.5% NaCl solution at room temperature. The results indicated that the general corrosion resistance of wire arc additive manufacturing (WAAM) samples were quite similar to those of the counterpart ST-37 steel and the stress corrosion resistance of both alloys was adequate. Altogether, it was clearly evident that the WAAM process did not encounter any deterioration in corrosion performance compared to its conventional wrought alloy counterpart.
Analytical Modeling of the Mixed-Mode Growth and Dissolution of Precipitates in a Finite System
Authors: Naseri Tohid , Larouche Daniel , Martinez Rémi , Breton Francis , Massinon Denis
Published: August 2019

In this paper, a novel analytical modeling of the growth and dissolution of precipitates in substitutional alloys is presented. This model uses an existing solution for the shape-preserved growth of ellipsoidal precipitates in the mixed-mode regime, which takes into account the interfacial mobility of the precipitate. The dissolution model is developed by neglecting the transient term in the mass conservation equation, keeping the convective term. It is shown that such an approach yields the so-called reversed-growth approximation. A time discretization procedure is proposed to take into account the evolution of the solute concentration in the matrix as the phase transformation progresses. The model is applied to calculate the evolution of the radius of spherical θ-Al2Cu precipitates in an Al rich matrix at two different temperatures, for which growth or dissolution occurs. A comparison of the model is made, with the results obtained using the numerical solver DICTRA. The very good agreement obtained for cases where the interfacial mobility is very high indicates that the time discretization procedure is accurate.
Influence of Nickel Powders on Corrosion Resistance of Cold Sprayed Coatings on Al7075 Substrate
Authors: Scendo Mieczyslaw , Zorawski Wojciech , Goral Anna
Published: August 2019

The influence of the size and structure of nickel powder grains on the corrosion resistance of nickel coatings on an Al7075 substrate in an acidic chloride solution was investigated. The Ni coating was produced by the cold spraying (CS) method. The surface and microstructure of specimens were observed by a scanning electron microscope (SEM). The corrosion test of the materials was carried out by using the electrochemical method. It has been found that the size of Ni powders has a significant effect on the corrosion resistance of nickel coatings. The porosity of nickel coatings on the Al7075 alloy increases with the increasing size of nickel powders. The corrosion rate of nickel coatings in the chloride environment decreases as the diameter of the nickel powders decreases. On the other hand, the highest corrosion resistance of nickel coatings was obtained using the Ni powders of the irregular spherical or dendritic structure. Moreover, the large particles of nickel powder cause strong residual stress (compared to small grains) in the depth of the nickel coatings.
Initial β Grain Size Effect on High-Temperature Flow Behavior of Tb8 Titanium Alloys in Single β Phase Field
Authors: Yang Qiuyue , Ma Min , Tan Yuanbiao , Xiang Song , Zhao Fei , Liang Yilong
Published: August 2019

The high-temperature flow behavior of TB8 titanium alloys with two different grain sizes was investigated in this present work. Results show that a significant characteristic of stress drop is visible at the start stage of the hot deformation process when the strain rates are 100 and 10−1 s−1. With the further increasing of strain, the flow stress initially rises to a maximum value and subsequently attains a plateau for the strain rates of 100 s−1 and a slight decrease for the strain rates of 10−1 s−1. Only dynamic recovery occurs under these deformation conditions. When the strain rates drop to 10−3 s−1, the dynamic recrystallization takes place during hot deformation. The values of deformation activation energy and materials constants at different strains were calculated. The processing maps at different strains were established for the fine- and coarse-grained alloys. The optimal processing parameter for hot processing was attained to be 900 °C/10−3 s−1 for fine-grained alloys and 950 °C/10−3 s−1 for coarse-grained alloys, respectively.
Investigation on Springback Behavior of Cu/Ni Clad Foils during Flexible Die Micro V-Bending Process
Authors: Wang Chuanjie , Wang Shan , Wang Shuting , Chen Gang , Zhang Peng
Published: August 2019

With the increasing demand for micro parts using metal laminates in modern production, the manufacturing processes of thin sheet parts have been elevated. However, it is difficult to predict the deformation behavior with miniaturization because of size effects in micro-scale. In this study, the flexible die micro V-bending behavior of Cu/Ni clad foils was investigated. The bending experiments with three different punch angles and Cu/Ni clad foils under different annealed temperatures were performed. The results show that the springback angle increases with the increase of bending angle and annealing temperature. The placement of Cu/Ni clad foils induced compressive stress results in the more obvious thinning of thickness and decreasing of springback angle. The interactive effects of the distribution of deformation zones and compressive stress induced by the interface layer result in the springback behavior of Cu/Ni clad foils during the flexible die micro V-bending process.
Influence of Preaging Treatment on Bake-Hardening Response and Electrochemical Corrosion Behavior of High Strength Al-Zn-Mg-Cu-Zr Alloy
Authors: Li Hui , Liu Xiao-Teng , Wang Jia-Yi
Published: August 2019

The influence of preaging (PA) treatments on the bake hardening (BH) response of a AlZnMgCuZr aluminum alloy which served as automotive body structures were studied in this paper. A novel two-step PA treatment was particularly designed and further employed. The mechanical properties of the alloy were tested in detail. The microstructure was characterized by optical microscope (OM), transmission electron microscopy (TEM) and 3D measuring laser microscope (3D–MLM). Meanwhile, the corrosion behavior was investigated by electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization. The results indicated that the PA treatment was beneficial for the improvement of BH response after baking at 180 °C immediately after the solution treatment and the micro-hardness reached the peak value (194 HV) after 10 h holding, which had a percentage improvement of 110.87% compared to the hardness under the solution condition. The PA treatments decreased natural aging (NA) adverse effects, while it had the lowest NA effect and optimal BH response under 120 °C/20 min. Such a novel two-step PA treatment was revealed further to decrease the NA effect and increase the BH response compared to the optimal PA treatment, in particular, the BH value could reach 168 MPa and was 21.7% higher than that of optimal PA + NA treatment. The optimal corrosion resistance has been shown up by the combined characterizations of potentiodynamic polarization curves, EIS Nyquist plots, and 3D–MLM images.