bluuebunny/crossref_metadata_2025 huggingface dataset:
Şeybânî ve Serahsî’nin Kitâbü’l-Kesb’te Hadis Kullanma Yöntemi
Authors: DEMİR Abdulalim
Published: May 2023

Kendisinden sonra yazılan bütün Kesb kitaplarına kaynaklık eden Şeybânî’nin Kitâbü’l-Kesb’i, alanda yazılmış olan ilk eser olması hasebiyle önemlidir. Onu şerh edenler olduğu gibi eserlerinde kaynak olarak kullananlar da olmuştur. İslâm iktisadının temellerini oluşturan bu çalışma, ağırlıklı olarak zühd ve kazanç konusunu ele almıştır. Şeybânî ve şârihi Serahsî, Kesb’te konuları işlerken çok sayıda hadis kullanmışlardır. Onların genel olarak âyetleri, hadisleri ve kendi görüşlerini hadisle açıklama yöntemini takip ettikleri görülmüştür. Ele aldıkları hadisin yanlış anlaşılmasının önüne geçmek için makâsıdını ve garib kelimelerini de açıklamışlardır. Aktarmış oldukları hadislerin sened zincirini hazfetmeleri, faydalandıkları hadislerin isnad açısından tahlil edilememesine yol açmıştır. Bununla birlikte aktarmış oldukları hadislerin çoğunun yakın anlamlısını temel hadis kaynaklarında bulmak mümkündür. Şeybânî ve Serahsî’nin Kitâbü’l-Kesb’te hadis kullanma yöntemlerinin ele alındığı bu makale Kesb’in yazılma nedeni, önemi, muhtevası, Kesb’te hadis kullanma ve yorumlama metodu, Kesb’te kullanılan hadislerin sened ve sıhhat bakımından değerlendirilmesi başlıkları ve alt başlıkları etrafında şekillenmiştir.
PICOSECOND PULSED LASER DEPOSITION OF MOS2 THIN FILMS
Authors: QUIÑONES-GALVAN JOSE GUADALUPE ,   Departamento de Fisica, Centro Universitario de Ciencias Exactas e Ingenierias, Universidad de Guadalajara, MIRZA INAM , HRABOVSKY JAN , CAMPOS-GONZALEZ ENRIQUE , DE MOURE-FLORES FRANCISCO , SANTOS-CRUZ JOSE , SANTANA-ARANDA MIGUEL ANGEL , BULGAKOV ALEXANDER V. , M. BULGAKOVA NADEZHDA ,   HiLASE Centre, Institute of Physics of the Czech Academy of Sciences,   HiLASE Centre, Institute of Physics of the Czech Academy of Sciences,   Departamento de Fisica, Centro Universitario de Ciencias Exactas e Ingenierias, Universidad de Guadalajara,   Facultad de Quimica, Materiales, Universidad Autonoma de Queretaro,   Facultad de Quimica, Materiales, Universidad Autonoma de Queretaro,   Departamento de Fisica, Centro Universitario de Ciencias Exactas e Ingenierias, Universidad de Guadalajara,   HiLASE Centre, Institute of Physics of the Czech Academy of Sciences,   HiLASE Centre, Institute of Physics of the Czech Academy of Sciences
Published: May 2023

MoS2 thin films were grown by the pulsed laser deposition technique using a picosecond laser at a wavelength of 1030 nm. The plasma ion mean kinetic energy and density were estimated from the time-of-flight distributions measured using a Langmuir planar probe. It has been found that the mean kinetic energy decreases with increasing the laser pulse energy. This unusual effect is explained by the difference in the volatility of the vaporized species. Samples were structurally characterized by Raman spectroscopy and grazing angle X-ray diffraction. It was found that thin films of amorphous matrices containing MoS2 nanocrystallites were grown. Optical characterization carried out by UV-vis spectroscopy yielded transmittance values above 90% in the visible spectral range and an indirect electronic transition at 1.4 eV. Chemical oxidation states for molybdenum and sulfur were analyzed by means of X-ray photoelectron emission spectroscopy, which revealed Mo-S bonding states, confirming the growth of MoS2.
DEVELOPING A MOBILE ROBOT WITH VOICE COMMANDS
Authors: BOZEK PAVOL ,   Slovak University of Technology in Bratislava, Faculty of Materials Science and Technology, Institute of Production Technologies, PIVARCIOVA ELENA ,   Technical University in Zvolen, Faculty of Technology, Department of Manufacturing and Automation Technology
Published: May 2023

The paper deals with the development of a transport robot control system with voice commands and simulation of their movement in Microsoft Robotics Developer Studio (MRDS) software product. The advantages of MRDS over other programmes are discussed. The programming language used was VPL, a visual programming environment for creating and debugging applications. It was designed multi-level control of the robot. At the top level of control, human voice commands are recognised, setting the direction of movement of the robot and its motion functions. At the lower level, the wheel speed is controlled by a microcontroller, which generates pulse width modulation output signals.
FORECASTING THE CUTTING TOOL LIFE CONSIDERING AS A BLOW-UP MODE ITS OPERATION
Authors: PANDA ANTON ,   Technical University of Kosice, Department of Automotive and Manufacturing Technologies, Faculty of Manufacturing Technologies with a seat in Presov, NAHORNYI VOLODYMYR ,   Sumy State University, Department of Computer Science, Faculty of Electronics and Information Technologies
Published: May 2023

The article considers а method for real-time forecasting the cutting tool life, considering as a blow-up mode its operation. The method based on the selection of a log-periodic component in the audio signal accompanying the cutting process. The model of this component contains as the main parameter the time taken as the tool life. To ensure the process control efficiency, when making a decision to stop the cutting process, the residual tool life is determined, which is equal to the difference between the tool life prediction and the current part processing duration.
KNOWLEDGE MANAGEMENT AND ITS USE IN AN IDUSTRIAL ENTERPRISE
Authors: PERGNER PETR ,   West Bohemia University in Pilsen, Faculty of Mechanical Engineering, Department Of Industrial Engineering and Management, HOREJC JAN ,   Czech Technical University in Prague, Faculty of Mechanical Engineering, Department of Business Management and Economics
Published: May 2023

Knowledge management arose as a result of the need to incorporate the dynamics of an enterprise environment into an enterprise model. It requires a holistic approach integrating technological and human aspects by building and developing key competencies. Knowledge management makes possible correct strategic decisions, correct investments into product, minimizing risks, process innovations and effective update of the business strategy. Furthermore it leads to reduction of costs, improvement of quality in all aspects of an enterprise and reduction of delivery times of goods and services. In the knowledge enterprise, the creation of an internal climate favourable towards innovative approaches, employee development, cooperation between employees, knowledge sharing and fulfilment of organization goals must be provided. A synergy of functions is crucial for managing a knowledge enterprise.
METHODS FOR DETERMINING THERMAL ERRORS IN MACHINE TOOLS BY THERMO-ELASTIC SIMULATION IN CONNECTION WITH THERMAL MEASUREMENT IN A CLIMATE CHAMBER
Authors: GEIST ALEXANDER ,   Fraunhofer Institute for Machine Tools and Forming Technology IWU, NAUMANN CHRISTIAN , GLANZEL JANINE , PUTZ MATTHIAS ,   Fraunhofer Institute for Machine Tools and Forming Technology IWU,   Fraunhofer Institute for Machine Tools and Forming Technology IWU,   Chemnitz University of Technology, Prof. Production Systems and Processes
Published: May 2023

Thermo-elastic deformation of the machine tool due to thermal expansion of machine components presents one of the biggest challenges in maintaining accuracy and product quality. The operation of the machine inevitably leads to waste heat due to friction losses of bearings and guides and electrical losses of motors and control cabinets. These internal heat sources lead to inhomogeneous and changing temperature fields, which also interact with the ambient temperature. An interaction with the environment takes place via natural or forced convection and radiation. During the design phase, these thermal effects are determined using thermal (typically FEM) simulations. For existing machines, thermal measurements are possible but require careful planning and execution. Thermo-elastic FEM simulations coupled with thermal measurements in a climate chamber with controlled ambient and foundation temperature, lead to an optimal understanding and management of thermal errors in machine tools. In this paper, the process of thermo-elastic FEM in connection with measurement principles in a climate chamber will be presented. The five-axis milling machine tool DMU 80 evo is used to demonstrate and validate the results of the thermo-elastic FEM with measurement data.
The Effect of Resampling on Classifier Performance: an Empirical Study
Authors: Pujianto Utomo , Akbar Muhammad Iqbal , Lassela Niendhitta Tamia , Sutaji Deni
Published: May 2023

An imbalanced class on a dataset is a common classification problem. The effect of using imbalanced class datasets can cause a decrease in the performance of the classifier. Resampling is one of the solutions to this problem. This study used 100 datasets from 3 websites: UCI Machine Learning, Kaggle, and OpenML. Each dataset will go through 3 processing stages: the resampling process, the classification process, and the significance testing process between performance evaluation values of the combination of classifier and the resampling using paired t-test. The resampling used in the process is Random Undersampling, Random Oversampling, and SMOTE. The classifier used in the classification process is Naïve Bayes Classifier, Decision Tree, and Neural Network. The classification results in accuracy, precision, recall, and f-measure values are tested using paired t-tests to determine the significance of the classifier's performance from datasets that were not resampled and those that had applied the resampling. The paired t-test is also used to find a combination between the classifier and the resampling that gives significant results. This study obtained two results. The first result is that resampling on imbalanced class datasets can substantially affect the classifier's performance more than the classifier's performance from datasets that are not applied the resampling technique. The second result is that combining the Neural Network Algorithm without the resampling provides significance based on the accuracy value. Combining the Neural Network Algorithm with the SMOTE technique provides significant performance based on the amount of precision, recall, and f-measure.
Hybrid Artificial Bee Colony and Improved Simulated Annealing for the Capacitated Vehicle Routing Problem
Authors: Mar'i Farhanna , Ubaidillah Hafidz , Mahmudy Wayan Firdaus , Supianto Ahmad Afif
Published: May 2023

Capacitated Vehicle Routing Problem (CVRP) is a type of NP-Hard combinatorial problem that requires a high computational process. In the case of CVRP, there is an additional constraint in the form of a capacity limit owned by the vehicle, so the complexity of the problem from CVRP is to find the optimum route pattern for minimizing travel costs which are also adjusted to customer demand and vehicle capacity for distribution. One method of solving CVRP can be done by implementing a meta-heuristic algorithm. In this research, two meta-heuristic algorithms have been hybridized: Artificial Bee Colony (ABC) with Improved Simulated Annealing (SA). The motivation behind this idea is to complete the excess and the lack of two algorithms when exploring and exploiting the optimal solution. Hybridization is done by running the ABC algorithm, and then the output solution at this stage will be used as an initial solution for the Improved SA method. Parameter testing for both methods has been carried out to produce an optimal solution. In this study, the test was carried out using the CVRP benchmark dataset generated by Augerat (Dataset 1) and the recent CVRP dataset from Uchoa (Dataset 2). The result shows that hybridizing the ABC algorithm and Improved SA could provide a better solution than the basic ABC without hybridization.
A Demographic Profile of the Greater Lancaster County, Pennsylvania, Amish
Authors: Donnermeyer Joseph F.
Published: May 2023

This article provides a demographic profile of the Amish in the Greater Lancaster County settlement, the oldest extant community and the largest in the world today. A dataset, based on a sample of about one in five households (N = 1,494), was developed from the 2015 directory for the Greater Lancaster settlement. The data is summarized along 10 major topics, including widows and widowers, ordained men, occupations of men, age at first marriage, most popular months for weddings, most popular days for weddings, number of children, birth intervals, stillbirths and infant deaths, and age and sex distribution of the population. The results are compared with the findings from a study of the Lancaster County Amish by Elmer Lewis Smith, published in 1960, that includes selected population statistics from the first half of the twentieth century and information that goes back to the final decade of the nineteenth century. The findings show a great deal of demographic stability; that is, trends in such demographic features as family size show only small, incremental changes. Only infant mortality and the occupations of men have shifted significantly. The article concludes by discussing the need for additional demographic research utilizing directories from other communities, large and small, old and new, and of different Amish groups based on the relative conservatism vs. progressivism of their church disciplines.
Psychometric properties of COVID-19 Exhaustion Scale in Italian context
Authors: Zammitti Andrea , Zarbo Rita , Russo Angela , Magnano Paola
Published: May 2023

The aim of this study was providing a validated scale in the Italian context, for the assessment of the symptoms of mental, physical, and psychological exhaustion that can result from thinking about COVID-19, starting from Burnout Measure of Pines and Aronson. Four studies were conducted. In Study 1, we conducted an exploratory factor analysis. A 2-factor factorial structure—Mental Exhaustion (ME) and Physical and Emotional Exhaustion (PEE)—was shown. In Study 2, we tested the structure of COVID-19 Exhaustion Scale. The two-factor structure with 8 items was the best factorial solution. In Study 3, we tested the concurrent validity of the COVID-19 Exhaustion Scale. The two dimensions were significantly and positively related to physical symptoms and negatively related to life satisfaction. In Study 4, we showed the stability of the COVID-19 Exhaustion Scale using the test-retest method after 3 weeks.
Flipped classroom pedagogy in higher education in EFL contexts: Findings and implications for further research
Authors: Hoque Mohammed Shamsul , Islam Monjurul , Thurairaj Saraswathy , Puteri Zarina MK , Farahdina Tamanna
Published: May 2023

The primary aim of this article is to examine the existing findings of flipped classroom (FC) pedagogy in higher education institutions (HEIs) for teaching English as a foreign language (EFL) context. Relevant studies have been scrutinised based on keywords, such as higher education, online learning, blended or hybrid teaching, flipped classrooms, and English language instruction in EFL environment. A total of 54 out of the selected 162 articles were analysed using the critical review process as the research methodology, and data were analysed using the content analysis technique. The findings revealed that flipped classroom (FC) had been applied in different parts of the world over many years. But, most of the studies are in science and engineering. Flipped classroom (FC) in the English as foreign language context has remained untapped. Most of the studies conclude that flipped classroom (FC) has more benefits compared to its drawbacks. This review makes several recommendations for further study.
Perbandingan Standardized Precipitation Index dan Standardized Anomaly Index untuk Penentuan Tingkat Kekeringan di Kabupaten Sragen, Jawa Tengah
Authors: Ramdhani Muhammad Zaki , Arifianto Fendy , Giarno Giarno
Published: May 2023

Kekeringan adalah suatu peristiwa dimana terjadinya penurunan intensitas curah hujan dan mengakibatkan krisis air untuk menunjang kebutuhan sehari hari manusia. Kasus kekeringan selalu terjadi setiap tahun di Jawa Tengah dengan berbagai macam dampak yang ditimbulkan. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan pada indeks kekeringan yang digunakan, yaitu indeks kekeringan Standardized Precipitation Index (SPI) dan indeks kekeringan Standardized Anomaly Index (SAI). Penelitian ini dilakukan dengan menggunakan metode analisa secara spasial menggunakan metode perhitungan indeks kekeringan SPI dan SAI. Hasil yang diperoleh yaitu pada perhitungan menggunakan rumus SPI maupun SAI untuk menentukan tingkat kekeringan di Kabupaten Sragen periode 2011-2020 memiliki kesamaan pola sebesar 89% untuk tahun kering dan tahun basah. Selain itu, kasus kekeringan di Kabupaten Sragen untuk setiap tahunnya di dominasi oleh kategori normal. Tahun kekeringan terjadi pada tahun 2012, 2015, 2018 dengan kasus kekeringan sedang, tahun 2014 dan tahun 2019 dengan kasus kekeringan parah.
Analisis Perencanaan Ulang Alinyemen Horizontal dan Pelebaran Perkerasan Tikungan di Ruas Jalan Nasional Gumitir (STA 231+000 - STA 235+100)
Authors: Utomo Nugroho , Fatikasari Aulia Dewi
Published: May 2023

Kematian dan kerusakan akibat kecelakaan jalan raya di tikungan lebih banyak dibandingkan jalan lurus. Tikungan tajam merupakan lokasi yang sangat rawan terjadi kecelakaan. Salah satu Jalan Nasional yang sering terjadi kecelakaan di bagian tikungan yaitu Jalan Raya Gumitir dengan tipe jalan 2/2 UD dengan lebar 6 meter. Menurut data kecelakaan lalu lintas pada tahun 2017-2020 terjadi 30 kejadian kecelakaan. Maka perlu adanya perencanaan ulang yang merujuk pada aspek keselamatan pengguna jalan pada bagian alinyemen Horizontal dan area tikungan yang membutuhkan pelebaran. Data yang dibutuhkan yaitu data geometri jalan eksisting dan peta topografi lalu dianalisis untuk perhitungan alinyemen Horizontal dan pelebaran jalan berdasarkan Tata Cara Perencanaan Geometrik Jalan Antar Kota Nomor 38/T/BM1997. Hasil analisis yaitu alinyemen horizontal sebanyak 23 tikungan dengan rincian 11 tikungan Spiral–Spiral(SS), 6 tikungan Full Circle(FC) dan 6 tikungan Spiral–Circle–Spiral(SCS) dan rata-rata pada setiap tikungan membutuhkan pelebaran sekitar 10 meter.
Analysis of Tensile Strength and Water Absorption Properties of Glass-Ramie Hybrid Laminated Composite
Authors: Yudhanto Ferriawan
Published: May 2023

Hybrid layered composites (HLC), combining natural and synthetic fibers, are mainly used in the automotive composite industry. The factor determining the inter-mechanical bond between layers impacts the mechanical strength.. Ramie fibers were immersed in a 5 wt.% NaOH solution for 2 hours to remove lignin and hemicellulose content in the fiber surface. Alkali treatment increases the adhesion bond between cellulose and the polyester matrix. The treated ramie fibers to be weaved by traditional machine to produce the woven ramie. The three-layer fibers are manufactured by press mold with a 2-bar pressure. The characterization of HLC for tensile strength according to ASTM D638 and water absorption refers to ASTM D570. The excellent tensile strength and elastic modulus of HLC have a stacking sequence of woven ramie-unidirectional glass-woven ramie (WR-UG-WR) by 150 MPa and 24.1 GPa, respectively, and its lowest water absorption by 3.31%.
Investigating the predictive effect of neutrophil to lymphocyte ratio as an inflammatory marker in the spontaneous excretion of ureteral stones
Authors: Deldadeh-Moghaddam Hamid , Cheraghi-Digaleh Tina
Published: May 2023

Background: The size and location of the stone have been suggested as the most important predictors of the possibility of spontaneous passage of the stone. The aim of this study was to investigate the predictive effect of neutrophil to lymphocyte ratio as an inflammatory marker in the spontaneous excretion of ureteral stones.
Methods: This descriptive-analytical study was done on 95 patients with ureteral stone during 2020-21. Required data include sex, age, BMI, previous history of stone, previous history of spontaneous passage of stone, side, location and size of stones, spontaneous passage of stone, and neutrophil and lymphocyte ratio were extracted from file of patients. The presence of the stone and its characteristics were confirmed by ultrasound. Patients were followed up for 2 weeks to determine whether or not the stone passed spontaneously.
Results: There was a significant relationship between spontaneous passage of ureteral stone with stone size, location, and neutrophil to lymphocyte ratio. The cut-off points of neutrophil to lymphocyte ratio for predicting spontaneous passage of ureteral stone was 2.52, so that patients with higher values were faced with a 4.2-fold increase in the risk of no spontaneous passage of stones (OR=4.202, 95% CI: 1.563-11.298, Sig.=0.004).
Conclusions: The results of the study showed that the ratio of neutrophils to lymphocytes is a significant predictor of spontaneous passage of ureteral stones, so that if used in addition to the size and location of the stone, the accuracy of predicting patients who benefit from conservative management, increase significantly.
Evaluation of disease distribution and drug utilization for management of psoriasis patients in dermatology OPD of a tertiary care centre: a retrospective observational study
Authors: Badar Vandana , Chavan Rachana R. , Chokhandre Mrunalini , Pradhan Kalyani
Published: May 2023

Background: Psoriasis is a chronic skin disorder that can have different clinical presentations. Topical corticosteroids are the primary therapy for psoriasis, but there are many new drug options approved for its treatment. The aim of this study was to assess the prescription patterns and disease distribution of psoriasis patients in a tertiary care center in central India.
Methods: We conducted a retrospective observational study of 195 psoriasis patients treated in the Dermatology OPD of a teaching hospital from September 2020 to June 2021. We analyzed patient data for demographics, disease characteristics, and medications prescribed using frequency distributions in Microsoft Excel.
Results: Plaque psoriasis was the most common clinical variant among the patients, and the male to female ratio was 1.5:1. February had the highest number of patients treated, indicating an aggravation of symptoms during cold weather. Most patients (93.33%) were prescribed topical corticosteroids, with clobetasol being the most commonly used medication (78%). The average number of drugs per prescription was 5, with other drugs prescribed including emollients (53.33%), vitamin D (31.7%), anti-histamines (21.02%), and methotrexate (5.1%).
Conclusions: Topical corticosteroids, particularly clobetasol, were the most commonly prescribed medication for psoriasis patients in this study. Multiple drugs were needed for the management of most patients. The study provides insights into the prescription patterns of psoriasis medications, which may improve patient care and outcomes.
Likelihood of rising stroke in populace of western India: a case control study
Authors: Patel Kuntal H. , Shroff Bhavesh D.
Published: May 2023

Background: Cerebrovascular accident (Stroke) is a non-communicable disease of increasing importance. According to the World Health Organization, 15 million people suffer from stroke worldwide each year. The National Commission on Macroeconomics and Health, India, has estimated 1.67 million stroke cases in India. Due to the increasing prevalence of hypertension, diabetes, dyslipidemia, fast changing lifestyle and re-structuring of population, stroke will be an epidemic in India in the days to come. Few studies have been carried out in developing countries like India. So, this study intended to know the presentation in addition to risk factors, patterns of warning signs and symptoms of stroke in patients admitted to state tertiary care Hospital.
Methods: Assuming the power ratio of the number of controls same as numbers of cases specifying values for two sided confidence level 95% and odd ratio 2.15 which was the minimum risk factor in previous study was taken to calculate sample size.
Results: After studying of 148 cases of stroke and same controls, we conclude that most common type of stroke is ischemic stroke followed by haemorrhagic stroke. After multivariate analysis we found, modifiable risk factors were mainly mental stress, active and passive smoking, hypertension and obesity.
Conclusions: Due to the sheer magnitude, devastating consequences and residual sequelae of the stroke, early intervention in the form of patient education, modification of the lifestyle, non-pharmacological and pharmacological interventions for modifiable risk factors should be an integral aspect of patient care.
Association of serum iron studies in COVID associated mucormycosis with stage of the disease
Authors: Rao Chaitra , V. S. Sheshan , R. Madhumathi , Malagi Aishwarya D. , B. Vidyasagar
Published: May 2023

Background: Mucormycosis is a rare and lethal invasive fungal infection caused by opportunist and ubiquitous fungi. India has reported surge in cases of post COVID 19 mucormycosis due to the increasing frequency of risk factors like corticosteroid therapy, uncontrolled diabetes, DKA, neutropenia and iron overload and hence warrants a detailed study to identify potential contributing factors. Aim of this study was to study the clinical profile of patients with CAM and to correlate serum iron studies with severity and extent of disease in CAM patients.
Methods: This prospective crosssectional study was conducted on 75 patients with CAM admitted to Bowring Hospital, Bangalore. Detailed history with clinical evaluation and appropriate investigations done and data was analysed.
Results: The mean age of the subjects was 48.19 with 52 males and 23 females. Among 75 patients 90.7% were unvaccinated against COVID, 62.7% had oxygen and steroid use, with diabetes mellitus as most common comorbidity. Rhino orbital-cerebral mucormycosis was the most common clinical presentation. Patients with stage 4 CAM had elevated levels of inflammatory markers LDH (292), D-dimer (457), CRP (74.64), mean serum iron (50.37) and TIBC (255.37). Case fatality rate was 12%.
Conclusions: The results of this study revealed significant correlation between the clinical severity of CAM and higher mortality, with increased serum iron levels and inflammatory markers. Therefore patients with elevated levels of available serum iron are uniquely susceptible to mucormycosis infection, suggesting dysregulated iron metabolism in its pathogenesis.
Prevalence of hypertension and diabetes in health workers of Jabalpur and Dindori: a brief study
Authors: Sengar Gautami Singh , Singh Kritika , Dey Arpan , Shrivastava Suyesh
Published: May 2023

Background: Hypertension and Diabetes comprises a major part as precursor of crucial diseases like cardiovascular diseases. Cardiovascular diseases are cause of death of around 17 million people per year globally, which includes 30% of total deaths.
Methods: The present study was conducted to observe the prevalence of hypertension and diabetes among health care worker groups, in different health care centres at Bajag block of Dindori district & Indian council of Medical Research- National Institute for research in Tribal Health (ICMR-NIRTH) Jabalpur during the study period from January 2022 to June 2022. The participants were subjected to anthropometric measurements, Blood pressure & blood glucose level measurements and they also responded to the detailed questionnaire.
Results: The 95 health care workers including nurses, technicians, ASHA workers, ANMs, which were assessed in the present study have shown 14.7% diabetes and 38% hypertension.
Conclusions: The present study is important step towards the wellbeing of health workers as very few efforts were made to observe the prevalence of NCDs in health workers of rural areas.
Clinico-epidemiological profile and treatment outcome of lip cancer: a retrospective study from north India
Authors: Tali Tavseef Ahmad , Amin Fiza , Khan Nazir Ahmad , Dar Javaid Ahmad , Sofi Mushtaq Ahmad
Published: May 2023

Background: Aim of present study to evaluate the Clinico-epidemiological profile and treatment outcome of Lip Cancer.
Methods: This was a retrospective study performed in our hospital. All necessary clinical and epidemiological details of the 11 cases diagnosed with lip cancer from January 2016 to December 2021 were analysed.
Results: The total number of new malignant cases diagnosed as lip cancer between January 2016 and December 2021 were 11, which comprised 6 male (55%) and 5 (45%) female. The male-to-female ratio was (1.2:1). The most common histological type was SCC, i.e., in 9 (81.8%) of the total number of cases and BCC was in 2 patients (18.2%). Overall survival at 5 years was 89% in our study.
Conclusions: In conclusion, we have reported higher levels of lip cancer among men and those above 45 years of age. The important prognostic factors for overall survival in these patients were cancer stages. Better survival is achieved with surgery alone in the early stages and with adjuvant radiotherapy in the later stages.
Effect of remdesivir on mortality rate, need of intubation and mechanical ventilation in COVID-19 positive patients: a retrospective observational study
Authors: Nikalje Anand , Tripathy Srabani , Talekar Rahul S. , Mane Sumedh B.
Published: May 2023

Background: The symptoms of SARS-CoV-2 infection vary widely, from asymptomatic disease to pneumonia and life-threatening complications, including acute respiratory distress syndrome, multisystem organ failure, and ultimately, death. Remdesivir has broad spectrum of activity against members of several virus families, including filoviruses and coronaviruses. Remdesivir is a potent inhibitor of SARS-CoV-2 replication in human nasal and bronchial cells.
Methods: This is a prospective and observational study conducted in patients of either gender, age more than 18 years with confirmed diagnosis of COVID-19 by RT-PCR. A predesigned, pretested and semi structured questionnaire containing socio demographic details like age, sex, BMI, comorbidities, findings of systemic examination of the cases, dose and duration of Remdesivir received and adverse effect due to therapy was used to collect the data.
Results: Mean age of the patients were 56.19±10.93 years. Male patients were 66% and 34% patients were female. After receiving the remdesivir, 43% of the patients needed bag mask and 27% of the patients maintained on room air oxygen. Non-invasive ventilation required in 19% of the patients and 11% of the patient required mechanical ventilation. s14% of the patients needed admission in the ICU. 3.5% of the patients were died and 96.5% patients were discharged from the hospital.
Conclusions: Remdesivir reduces the need of non-invasive oxygenation and mechanical ventilation. Mortality was seen in 3.5% patients, henceforth remdesivir, is an effective drug for moderate to severe COVID-19, if given in early stages of infection.
Antibiotic susceptibility pattern of gram-negative bacterial isolates with special mention on colistin resistance from Intensive Care Unit of a tertiary care hospital: a prospective study assessing the impact of microbial resistance on clinical outcomes
Authors: Ravi Preethika , C. Ravindranath , S. Deepa
Published: May 2023

Background: The frequent use of broad-spectrum antibiotics in ICU leads to increased rates of antimicrobial resistance and occurrence of multidrug-resistant (MDR) micro-organisms. The aim of this study was to evaluate the antimicrobial resistance pattern and colistin susceptibility among bacterial isolates from ICU patients.
Method: It is a prospective study with 70 nonrepetitive isolates from ICU samples. The clinical data was obtained from the department records. The gram-negative bacterial isolates were identified by conventional biochemical tests. The antimicrobial susceptibility was determined by Kirby-Bauer disc diffusion method. ESBL producers were detected by double disc diffusion test using ceftazidime, cefotaxime alone and in combination with clavulanic acid. MBL detection was done by imipenem+ EDTA combined disc diffusion test. Colistin sensitivity was determined by broth microdilution according to CLSI guidelines.
Results: Out of 70 culture positive specimens. The most common gram-negative bacteria isolated from the samples was Acinetobacter spp. (41%), followed by Klebsiella spp. (20%). Among these 45% were MBL producers, 38.5% were ESBL producers and 14% were both ESBL and MBL producers. Colistin resistance was present among 5.7% isolates in ICU.         
Conclusions: Non-fermenters were the most common agent causing ICU infections. An alarmingly high rate of resistance to antibiotics especially to colistin in ICU-acquired infections, necessitates new therapeutic strategies to prevent the emergence and control of antimicrobial resistance.
Xanthogranulomatous orchitis: a case series
Authors: Sambhus Tanvi R. , Sharma Swati , Pai Kanthilatha , Mathew Mary
Published: May 2023

Xanthogranulomatous orchitis (XGO) is a sporadic disorder that has no definite aetiology and is a mimicker of several conditions, most significant of which are testicular neoplasms. We present a case series of three cases. The first case presented with swelling in his scrotum. The second case presented with similar symptoms and had prior history of trauma to the scrotum. Both cases were clinically diagnosed with testicular tumour. The third case was a referred case of left chronic orchitis with sinus tract. All three patients underwent high inguinal orchidectomy. Regardless of clinical work-up and diagnoses, upon histopathological evaluation, all three cases were diagnosed with XGO. This study explores the variety of risk factors and aetiologies that may result in XGO.
An overview of laparoscopic closure of duodenal perforation in a tertiary care centre
Authors: Kshetrimayum Gobind , Sanjenbam Shyamchand , Vumkhoching Rosemary , Khumallambam Ibomcha , Achom Ranjita , Ingudam Mahendra , Thokchom Amataleima
Published: May 2023

Duodenal ulcer perforation is one of the most commonly encountered condition in emergency surgery. Laparoscopic repair of the perforation has been reported in many cases since the first laparoscopic repair of a duodenal perforation in the year 1990 by Mouret et al. Aim and objectives were to study the clinical outcomes of laparoscopic repair of duodenal perforation in terms of duration of surgery, post operative pain, initiation of oral feeds, surgical site infection and duration of hospital stay. Over a 2 year period, 2018-2020, 20 patients with a presumptive diagnosis of perforated duodenal ulcers were considered for laparoscopic closure. Primary closure of the perforation was done with intracorporeal suturing followed by omental patch repair. The mean age was 38.75±8.53 years, mean duration of surgery was 97.80±7.89 minutes. The mean number of analgesic injection was 2.90±0.72. The mean duration of initiation of oral feeds was 3.20±0.41 days. The mean duration of removal of drain was 4.65±0.75 days and mean duration of hospital stay was 6.20±0.41 days.  No intraoperative complications encountered. Postoperatively, none of the patients develop wound infections. In our setting, laparoscopic closure was found to be safe and a promising method in management of duodenal perforation as it appears to be more beneficial in terms of decreased post-operative pain, early initiation of oral feeds, decreased length of hospital stay and no major complications postoperatively. However, the procedure requires a surgeon with particular expertise in endoscopic suturing skills.
Mimicking Mills’ syndrome: progressive spastic hemiparesis on upper motor neuron dominant amyotrophic lateral sclerosis
Authors: Montemayor Elizer M. , Marissa T. Ong  , Renato D. Dejan J.  , Evelyn O. Chua-Ley
Published: May 2023

Mills’ syndrome is an idiopathic, slowly progressive, spastic hemiparetic variant of primary lateral sclerosis (PLS). Despite this classic definition, this syndrome has recently been suggested to be present on all the variants of motor neuron disease (MND) spectrum (ALS, PLS or UMNdALS). Authors presented a 63 years old male with history of gradually progressive right-side hemiparesis associated with dysarthria and dysphagia. Neurologic examination revealed intact cognition, weak bilateral orofacial muscles, marked right-side spasticity with hyperreflexia and mild sensory deficit, progressing to right-upper extremity atrophy upon follow-up. Relevant blood and CSF examinations were within normal limits. MRI of brain and cervical spine were unremarkable. electromyography (EMG), nerve conduction velocity (NCV), facial motor and blinks studies initially revealed no evidence of lower motor neuron involvement. Based on the revised El escorial criteria, patient was diagnosed as upper motor neuron dominant amyotrophic lateral sclerosis (UMNdALS) mimicking the classic PLS-Mills’ hemiparetic variant.
Cor-pulmonale: a rare presentation in a case of middle lobe syndrome
Authors: Ankit Abhishek  , Sinha Ajay Kumar , Aditya Vikram
Published: May 2023

Brock’s syndrome or middle lobe syndrome (MLS) is chronic or recurrent collapse of right middle lobe due to causes which may be obstructive or non obstructive. The pathogenesis is not completely understood. An expert committee of the world health organization defined cor pulmonale as hypertrophy of the right ventricle resulting from diseases affecting the function and/or structure of the lungs.” Cor pulmonale is a common heart disease and a leading cause of disability and death. We are reporting this association in a 65y old female who presented to the emergency with acute exacerbation of COPD with SpO2=64% room air. Chest X-ray and HRCT thorax showed features suggesting MLS and ECG shows features suggesting P pulmonale /right atrial enlargement. BNP too was elevated. Patient was resuscitated and put on mechanical ventilation after ABG showed respiratory acidosis. Appropriate treatment with bronchodilators and antibiotics was given.
Renal involvement in COVID-19: a review report
Authors: Pandey Pinki , Palli Megha , Sawhney Anshul , Dixit Alok
Published: May 2023

COVID-19 is recent emerging pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome- Coronavirus). It is seen mainly affecting lungs, but many recent studies have shown involvement of hematological, kidney, gastrointestinal and other systems. In kidneys it mainly affects the tubules and interstitial areas. The main pathology behind involvement of renal system in COVID-19 is due to presence of ACE 2 receptors in proximal tubules. These receptors are same like that found in lungs and they form binding sites for coronavirus and hence causing the disease. Therefore, patients presenting with raised serum urea and creatinine should be checked for potential renal damage caused by virus and their urine samples should also be tested for presence of coronavirus. Effective testing and prompt management will prevent this virus from being transmitted in community.
Analysis of histopathological findings of breast biopsies at a tertiary care centre
Authors: Shah Bimal , Shah Mita , Degloorkar Sarang , Parab Sanjay , Vijay Ria
Published: May 2023

Background: In India, breast cancer has become a leading cause of cancer death. The indication of a breast lump can be cause of great concern in most patients. While most of the lumps are benign in nature, there is a possibility of an increased risk of developing premalignant lesions. Any breast mass/lump requires histological diagnosis to get a clear picture of the lump associated problems.
Methods: This is a retrospective, descriptive and a cross-sectional study of all the patients with breast lumps seen in Bhaktivedanta Hospital and Research Institute from January 2018 till March 2022. Histopathology reports of breast biopsies of patients required at Bhaktivedanta Hospital and Research Institute were included in the study.
Results: The total number of cases of breast biopsies available were 449. These cases are grouped into benign and malignant cases which comprise of 276 (61.47%) and 173 (38.53%) cases respectively. The most common benign diagnosis observed was fibroadenoma which accounted for 184 (66.67%) cases. Based on age grouping, the 21-40 age group contained the maximum number of benign cases. The most common malignancy observed was of ductal carcinoma with 163 (94.21%) cases. Based on age grouping, the age group of 41-60 contained the maximum number of malignant cases.
Conclusions: It is imperative that all breast lesions should undergo biopsies irrespective of clinical findings for the following reasons: rising incidence of breast cancer, to rule out/confirm malignancy and to complete the diagnostic triad of clinical diagnosis, radiology and pathology.
Breast cancer with synchronous renal cell carcinoma: a rare case of dual malignancy
Authors: Ranjan Ravi , Surya Pratap Mangipudi , Saurabh Gyan , Singh Ranvir
Published: May 2023

Synchronous breast and kidney carcinomas are extremely rare with only 11 cases have been reported in the literature so far in the world. We present a case of a 40-year-old lady diagnosed with right invasive ductal cell carcinoma. During the workup of the patient, an incidental renal mass was identified. After appropriate investigations, the patient underwent a right modified radical mastectomy with a right partial nephrectomy. The patient recovered successfully and was put on regular follow-up post-discharge. We are reporting a case of synchronous presentation of carcinoma breast with RCC which is rare since in world literature, most of the multiple malignancies reported are metastasis/metachronous breast carcinoma with RCC. The aetiology of synchronous malignancy is complex, some primary tumours may not be symptomatic and detected in the routine metastatic workup, and this poses a challenge for the surgical team. Hence with the histopathological report and with the other clinical and radiological parameters, we made a final diagnosis of carcinoma right breast pT2N0M0 with synchronous renal cell carcinoma (RCC) pT1aN0M0. the patient was planned for adjuvant chemotherapy and advised regular follow-up.
Selective nerve root block for management of symptomatic lumbosacral disc bulge causing radicular pain: A case series
Authors: Ghag Niranjan Sunil , Ambulgekar Rajesh Kishanrao , Ahire Priyanka Tanaji , Gautam Sudhanshu Kumar Gulabchand
Published: May 2023

: Back pain being the most common complaint faced by medical practitioner poses a great burden over health system. Clinical examination, MRI helps in making diagnosis in this spectrum of diseases. Of many modalities available selective nerve root block offer a micro invasive alternative for treatment and even evaluation of patients.

Peri-ganglionic selective nerve root block given in patient after complete clinical and radiological evaluation of patient. Patient was postoperatively followed up for 6 months with augmentation with physiotherapy and traction. Functional evaluation of patient done using VAS score, Modified Oswestry lower back pain disability questionnaire 6 months post-operatively.

: 25 patients included in this study showed a female prevalence with majority patients from 45-60 years of age group. L4 was the most common nerve root involved. In the study significant reduction in VAS score, Modified Oswestry lower back pain disability questionnaire score 6 month post-operatively found. VAS score was reduced from 8.24 to 3.28 and Modified Oswestry lower back pain disability questionnaire score from 31 to 12.76.

: Selective nerve root block is an effective method for evaluation and treatment of degenerative spine diseases patients. Which provide significant pain and symptomatic relief. Accompanied with vigorous back strengthening exercises this can offer a good functional outcome. This can act as a good screening tool for patients with degenerative spine diseases without red-flag signs for operative intervention. Future studies are warranted on this with larger sample size.
Beneficial effects of protocatechuic acid on diabetic retinopathy in streptozocin-induced diabetic rats
Authors: Wan Ling ,   Department of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan Province, China; Department of Ophthalmology, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, Sichuan Province, China, Chen Wei-Bai , Wu Guo-Qiang ,   Department of Ophthalmology, the First People’s Hospital of Lanzhou City, Lanzhou 730050, Gansu Province, China,   Department of Ophthalmology, the First People’s Hospital of Lanzhou City, Lanzhou 730050, Gansu Province, China
Published: May 2023

AIM: To determine the effects of protocatechuic acid (PCA) on streptozocin-induced diabetic retinopathy (DR) in rats.
METHODS: Wistar rats were given a 50 mg/kg intraperitoneal injection of streptozocin to induce diabetes. Animals were assigned randomly one of four groups (8 rats per group): control, diabetic, diabetic plus PCA (25 mg/kg•d), and diabetic plus PCA (50 mg/kg•d). After inducing diabetes, treatments were started one week later and continued for eight weeks. After the experiment, the rats were sacrificed, and their retinas were taken for biochemical and molecular analysis.
RESULTS: PCA administration diminished the blood glucose and glycated haemoglobin levels relative to the diabetic group. In diabetic rats, PCA lowered elevated levels of advanced glycosylated end products (AGEs) and receptor for AGEs (RAGE). In the retina of diabetic rats, PCA effectively decreased inflammatory cytokine, nuclear factor-κB, tumour necrosis factor-α, interleukin-1β, and vascular endothelial growth factor, and increased antioxidant markers glutathione, superoxide dismutase, and catalase.
CONCLUSION: The protective benefits of PCA against DR may be attributable to its suppression of the AGEs and RAGE and its antioxidant and anti-inflammatory properties.
Assessment of the effects of intrastromal injection of adipose-derived stem cells in keratoconus patients
Authors: Ramin Shahrokh ,   Department of Optometry, School of Rehabilitation Sciences, Incubation Center for Pharmaceutical Technology (ICPT), Shahid Beheshti University of Medical Sciences, Cell Therapy Department, Red Crescent Pharmaceutical and Clinical Complex, Tehran 1616913111, Iran, Ahadi Masoumeh , Rad Lina Moallemi , Kobarfad Farzad ,   Student Research Committee and Department of Optometry, School of Rehabilitation Sciences, Shahid Beheshti University of Medical Sciences, Tehran 1616913111, Iran,   Department of Molecular and Cell Biology,   Faculty of Basic Sciences, University of Mazandaran, Babolsar 4561745735, Iran
Published: May 2023

AIM: To evaluate the efficacy and safety of intrastromal transplantation of adipose-derived stem cells (ASCs) in keratoconus patients.
METHODS: This study was conducted on 8 eyes of 8 patients with moderate to severe keratoconus. In the patients, ophthalmic assessments including visual acuity, refraction, slit lamp examination, fundoscopy, corneal topography, and confocal microscopy were performed. Autologous stem cells were used. The isolated stem cells were injected into the corneal stroma by using femtosecond laser. Surgical procedure was similar to intracorneal ring implantation. All patients were re-assessed 1, 3, and 6mo after surgery.
RESULTS: The baseline mean visual acuity was 0.48±0.18 and improved to 0.66±0.17 after surgery and final acuity increased by 1.85±0.80 lines (P=0.001). The mean spherical refraction of patients improved 0.34±0.35 D (P=0.039), and the mean cylindrical refraction of patients improved 0.84±0.23 D (P=0.016). The mean flat keratometry decreased 0.78±0.71 D (P=0.017), and the mean steep keratometry decreased 0.59±0.68 D (P=0.023). The mean central corneal thickness of patients improved of 6.29±4.47 μm (P=0.03). The mean keratocyte density at the anterior and middle stroma of cornea increased (P<0.05) but remained stable at the posterior stroma after 6mo. All patients had no complications and their corneas remained transparent.
CONCLUSION: Intrastromal transplantation of ASCs has positive effects on vision and refractive parameters in most patients with keratoconus. After six months, visual acuity improved moderately, corneal parameters reduced slightly, and stromal keratocytes density increased. This modality is safe, and patients do not have any complications.