bluuebunny/crossref_metadata_2025 huggingface dataset:
Failed Peace in South Sudan? Exploring Unarmed Civilians and Local Peacekeepers through the Work of Nonviolent Peaceforce
Authors: Abd Rahman Muhammad Farid , Owojori Abimbola J. , Jaafar Faridah
Published: January 2023

Since the 2013 outbreak of civil war in South Sudan, the conflict has produced orgies of casualties and displacement of millions necessitating a series of mandates of the United Nations Mission in South Sudan (UNMISS). Yet, humanitarian crises and civilian protection challenges have not been reversed. To address these deficiencies, this article examined methods of the unarmed civilian peacekeeping as local peace formation and infrastructure involving the non-use of weapons for civilian protection as practiced by the Nonviolent Peaceforce (NP). Adopting ethnographic strands of Critical Peace Studies and utilisation of participant observations in humanitarian accounts with the NP between 2015 and 2019, our in-depth qualitative fieldwork indicates a potentially effective approach to unarmed civilian protection in the country. Our findings illuminate the limited viability of the UN civilian appointed personnel, while making an argument for the compelling efficacy of unarmed civilian peacekeepers in which those affected by the conflict are themselves empowered in their physical protection, the study further recommends the integration of the NP strategies into the current state of peace operation disarray so the current self-fulfilling prophecy of failed peace in South Sudan can be overturned.
Pelosi's Intoxication of Taiwan and Democrat's Flopped Performance in the US' Midterm Election
Authors: Hasija Namrata
Published: January 2023

Although traditionally, flopped performance of the Democrats in the US mid-term elections and Pelosi's failure to retain the majority of the house is expected, many analysts do not rule out the possibility of an increased significant connection between the development between the US election and events in the international politics. Therefore, it is highly likely for Taiwan to consider foreign policy options without US security protection in the face of China's threat under President Xi Jinping's third term is inevitable. This brief commentary provides views to answer some of the following questions; What is the most important international security lesson since the incident of Nancy Pelosi's visit as the former Leader of the United States (US) Congress to Taiwan last August 2022? How does the increasing tension in relations between Beijing and Washington foreshadow Taiwan's security future as it becomes increasingly dark and uncertain from the possible invasion of Mainland China?
40 Years of Malaysia's Look East Policy and Relocation of Indonesia's Capital: Serumpun Solution in Sarawak-West Kalimantan Cross-Border Halal Hub
Authors: Haron Ahmad Sharif , Othman Zarina , Wahab Andika
Published: January 2023

The relocation of Indonesia's new capital to Kota Nusantara (East Kalimantan) is a game changer. It creates a spill-over of the prosper thy neighbour policy upon the existing West Kalimantan-Malaysia Sarawak border for the first Japanese Big Eon in Kuching (Malaysia's Sarawak) and potential Halal Wagyu beef market in Pontianak (Indonesia's West Kalimantan). Both countries should seize this golden opportunity to revisit their respective Look East Policy (LEP) with Japan and integrate Japan's advantages in quality assurance to overcome different regulatory Halal practices. After all, sustaining the Halal economy is no longer determined by the growing Muslim population alone but a shared knowledge and mutual policy lessons on Halal regulations and quality assurance. While both countries are essential players in the global halal hub and shared trade borders, there needs to be more harmonisation between Kalimantan-Sarawak's cross-border halal framework. With the Indonesian decision to relocate to a new capital, Kota Nusantara (located in East Kalimantan), there is a severe immediate need to bring LEP's benefits and profile the existing business ecosystem in Kuching (the capital of Sarawak) and Pontianak (capital of West Kalimantan).
Automated Control of Unauthorized Power Take-Offs in a Distributed Electrical Network
Authors: Omorov T. T. , Zakiriaev K. E. , Takyrbashev B. K. , Imanakunova Zh. S.
Published: January 2023

A distributed electrical network (DEN) with a voltage of 0.4 kV operating in an unsymmetric mode is considered as an object of automated control. The problem of identification of places and control of unauthorized power take-offs (UPTO) in the DEN in the conditions of functioning of the automated system of control and accounting of electricity (ACMSE) is formulated. The primary source information for its solution is the data obtained from the head and subscriber electricity meters by synchronized remote measurements at discrete points in time. This problem belongs to the class of problems in which there is significant uncertainty about the current state of the object under study and the parameters of external disturbing influences, which are unauthorized consumers of electricity. Under these conditions, the primary measurement data on the characteristics of the network subscribers’ loads received from the counters of the automated system and recorded in its database are insufficient to solve the problem under consideration. In this regard, in order to reduce the level of uncertainty and obtain additional necessary information about the state of the object, the concept of a virtual DEN model is introduced into consideration, designed to describe its desired state, which is determined by the absence of these external random disturbances in the network. A new method for solving the formulated problem is proposed, based on the concept of a virtual DEN model. The conditions for identifying the current state of the DEN have been obtained. For this purpose, the desired input phase currents of the virtual network are determined by introducing equivalent complex resistances of certain parts of the three-phase network. The vectors of the effective values of currents and voltages on the loads of subscribers and inter-subscriber sections of the virtual network are identified. Criterion functions are introduced that determine the deviations of the corresponding components of the stress vectors on the loads of subscribers of the real DEN and its virtual model. Based on these functions, an identification criterion and an algorithm for monitoring unauthorized power take-offs in a three-phase distributed network are formulated. The obtained results are oriented for the creation of algorithmic and special software for the subsystem of automated control of UPTO as part of the ACMSE.
Didactic-Mathematical Knowledge and Teacher Education: An Investigation with Pre-Service and In-Service Mathematics Teachers
Authors: Fernandes Maia Pereira Solange , Kaiber Carmen Teresa
Published: January 2023

Background: The mathematical and didactic knowledge in mathematics teachers’ domain should constitute a permanent focus of investigations and reflections. Objective: To investigate the development of knowledge and procedures concerning geometry teaching among pre-service and in-service mathematics teachers engaged in the final years of elementary school. Design: The investigation is inserted in a qualitative perspective and follows the assumptions of action research. Setting and Participants: Fifty-four pre-service and in-service mathematics teachers from the Brazilian city of Paulo Afonso, Bahia, participated in a teacher education process. Data Collection and Analysis: Participant observation, data collection and analysis following an analysis protocol guided by the constructs of the onto-semiotic approach; analysis of productions. Results: Development and application of 24 sequences of activities focusing on the study of geometry. High epistemic adequacy was observed based on the application of the analysis protocol concerning structuring sequences of activities. Regarding the other dimensions, concerning the analysis of the application of the activities (cognitive-affective, interactional-mediational, ecological), high adequacy was observed. Conclusions: It is relevant to invest in teacher education courses proposing the expansion of didactic-mathematical knowledge to enhance the use of different ways to teach and learn mathematics.
Levantamento preliminar das borboletas (Lepidoptera, Papilionoidea) do Parque Nacional de Brasília e da Estação Ecológica de Águas Emendadas, Distrito Federal, Brasil
Authors: Pinheiro Carlos Eduardo Guimarães , Ribeiro Millena Castro
Published: January 2023

Neste estudo nós apresentamos uma listagem com 154 espécies de borboletas (Papilionoidea) registradas no Parque Nacional de Brasília e 165 espécies na Estação Ecológica de Águas Emendadas, correspondentes a inventários iniciados respectivamente nas últimas três e duas décadas. Uma avaliação dos estágios atingidos nestes inventários e estimativas do número de espécies esperado nestas unidades de conservação são também discutidas.
Mixomicetos associados à serapilheira da nogueira-pecan, Carya illinoinensis (Wangenh.) K. Koch (Juglandaceae)
Authors: Velloso Jorge Renato Pinheiro , Putzke Jair , Cavalcanti Laise de Holanda
Published: January 2023

A nogueira-pecan (Carya illinoinensis, Juglandaceae) foi introduzida no Brasil no início do século XX por imigrantes americanos e seu cultivo atualmente se estende desde o Rio Grande do Sul até Minas Gerais, com aproximadamente 2,4 mil hectares plantados. Apresenta-se o primeiro relato de mixomicetos associados à serapilheira de C. illinoinensis, diretamente observados no campo, esporulados sobre folhas secas (Physarum cinereum, P. melleum, P. polycephalum), gravetos e folhas secas (Diachea leucopodia) e galhos (Fuligo cinerea, F. septica, Hemitrichia serpula var. serpula). As espécies mais constantes foram P. melleum e D. leucopodia. Fuligo cinerea é registrado pela primeira vez para o Rio Grande do Sul; D. leucopodia e P. cinereum são citados pela primeira vez para a porção brasileira do Pampa, elevando para 61 o número de espécies conhecidas para o bioma.
Implications on crustal structure from the South Finland Coastal (SOFIC) deep seismic sounding profile
Authors:   Institute of Seismology, Department of Geosciences and Geography, University of Helsinki, Finland, Tiira Timo , Janik Tomasz ,   Institute of Geophysics, Polish Academy of Sciences, Warsaw, Poland, Veikkolainen Toni ,   Institute of Seismology, Department of Geosciences and Geography, University of Helsinki, Finland, Komminaho Kari ,   Institute of Seismology, Department of Geosciences and Geography, University of Helsinki, Finland, Skrzynik Tymon ,   Institute of Geophysics, Polish Academy of Sciences, Warsaw, Poland, Väkevä Sakari ,   Data and information Centre, Finnish Environment Institute, Helsinki, Finland, Heinonen Aku ,   Geological Survey of Finland, Espoo
Published: January 2023

We present results from a deep seismic sounding (DSS) experiment carried out along the southern coast of Finland in summer 2015. Data used in the survey derived from industrial blasts recorded by temporary project stations and permanent network stations. The western 220 km part of the 450 km long Southern Finland Coastal (SOFIC) profile runs along the Uusimaa belt (UB) in the 1.7–1.9 Ga Southern Finland subprovince (SFS) of the Svecofennian domain, while the 170 km part in the east crosses the 1.62–1.65 Ga Wiborg rapakivi batholith (WRB). The farthest 60 km cross a geologically diverse area consisting of supracrustal rocks and granitoids of the Saimaa area (SA), an eastern extension of the SFS. Our results show that the Moho boundary depth varies significantly, from ca. 52–54 km below UB to 40–45 km below WRB. All three crustal layers (upper, middle, and lower) have their maximum depth in the contact zone between UB and the WRB. Below WRB, a lower crust with Vp ~6.7–6.9 km/s is observed. High velocity lower crust was observed below UB (Vp ~7.2 km/s) and possibly below SA (Vp ~7.35 km/s). The modelling was based on ray tracing, using the extrapolation of seismic wave arrival times with the help of travel times predicted from a one-dimensional velocity model. The resulting two-dimensional velocity model partly relies on data from the intersecting DSS profiles and supports previous observations of the lithospheric structure of southeastern Fennoscandia.
TÜRKİYE'DE KONTEYNER TAŞIMACILIĞI ALANINDA HAZIRLANAN LİSANSÜSTÜ TEZLERİN BİBLİYOMETRİK ANALİZİ
Authors: Öçal Bora
Published: January 2023

Son yıllarda ortaya çıkan ve denizyolu taşımacılığının vazgeçilmez unsuru haline gelen konteyner taşımacılığı, günümüz dünya dış ticaret taşımalarında en yaygın kullanılan taşıma şeklidir. Konteyner taşımacılığının artan önemi karşısında yapılan bilimsel araştırmaların sayısı da o oranda artmaktadır. Bu araştırmanın amacı 1999-2022 yılları arasında Türkiye Cumhuriyeti Yükseköğretim Kurulu Başkanlığı Ulusal Tez Merkezi’nin internet sitesi üzerinden ulaşılabilen ve konteyner taşımacılığını konu alan lisansüstü tezlerin bibliyometrik analizini yapmaktır. Araştırma sonucunda yayımlanan lisansüstü tezlerin büyük çoğunluğunu yüksek lisans tezleri oluştururken, yazım dilinin de Türkçe olduğu tespit edilmiştir. Lisansüstü tezlerin en çok 2018 yılında, İstanbul ve İzmir’de bulunan kamu üniversitelerinde, sosyal bilimler enstitülerinde, işletme anabilim dalında yayımlandığı tespit edilmiştir. Ayrıca tezlerde en çok işletme konusunda çalışıldığı, anahtar kelime olarak konteyner taşımacılığının kullanıldığı ve tez danışmanı olarak profesör doktorların yoğunlukta olduğu tespit edilmiştir. Türkiye’nin dünya üzerindeki stratejik konumuna rağmen lisansüstü tezlerde konteyner taşımacılığını ele alan araştırma sayısı oldukça azdır.
Auto Signature Verification Using Line Projection Features Combined With Different Classifiers and Selection Methods
Authors: Malkawi Mohammad , Mardini Wail , Abu Zaitoun Toqa
Published: January 2023

: Signature verification plays a role in the commercial, legal and financial fields. The signature continues to be one of the most preferred types of authentication for many documents such as checks, credit card transaction receipts, and other legal documents. In this study, we propose a system for validating handwritten bank check signatures to determine whether the signature is original or forged. The proposed system includes several steps including improving the signature image quality, noise reduction, feature extraction, and analysis. The extracted features depend on the signature line and projection features. To verify signatures, different classification methods are used. The system is then trained with a set of signatures to demonstrate the validity of the proposed signature verification system. The experimental results show that the best accuracy of 100% was obtained by combining several classification methods.
Experience of use of the extended complex of ophthalmononeurostimulation in patients with non-exudative atrophic (geographic) form of age-of-aged macular degeneration
Authors: Drakon Alina K. , Korchazhkina Natalia B. , Sheludchenko Vycheslav M.
Published: January 2023

BACKGROUND: Non-exudative atrophic (geographic) macular degeneration of the retina is one of the causes of irreversible loss of central vision in the elderly. Its frequency of occurrence increases with age.
AIM: to evaluate the effectiveness of the extended complex of ophthalmoneurostimulation in patients with non-exudative atrophic (geographical) form of age-related macular degeneration.
MATERIAL AND METHODS: The study included 49 people (98 eyes) with geographic retinal atrophy, whose average age was 741.7 years, who were divided into 2 groups: group 1 ― 24 patients (48 eyes) aged 71.01.8 years, who underwent an extended complex of ophthalmoneurostimulation, including a course of endonasal electrophoresis of vitamin B12 (for a course of 10 daily procedures), transocular infrared stimulation (for a course of 10 daily procedures), oxygen therapy with Heliox-21 breathing mixture (for a course of 10 daily procedures), and acupuncture (for a course of 10 daily procedures), and group 2 ― 25 patients (50 eyes) aged 751.1 years, who underwent a course of conservative treatment with vitamins according to existing ophthalmological standards, which served as a background in group 1. Visual acuity was assessed (visual acuity), indicators of optical coherence tomography and optical coherence tomography with angiography function of the retina, local photosensitivity, autofluorescence of the retina and bioelectric potential in pattern-electroretinography. Studies were performed before therapy, after 2 weeks, 3 months, 6 months, and 12 months, after a course of treatment.
RESULTS: Visual acuity and anatomical parameters of the retina in high resolution (thickness of the central zone and the thickness of the choroid) did not change during the entire observation period. Analysis of light sensitivity showed a significant normalization of the average threshold of retinal photosensitivity when prescribing an extended complex of ophthalmoneurostimulation.
CONCLUSION: Conducted extended course of physiotherapy significantly reduced the functional depression of the central visual field, coordinating with foci of retinal pigment epithelium atrophy. Most likely, this positive effect was achieved due to the activation of the level of the ganglionic and bipolar layers of the retina.
Technology of magnetophoresis of topical nonsteroidal anti-inflammatory drugs in osteoarthritis (clinical and experimental study)
Authors: Osnovina Irina P. , Vladimirtseva Elena  L.
Published: January 2023

BACKGROUND: The high degree of evidence for the use of pharmacotherapy currently does not cause doctors to doubt, however, the use of non-pharmacological approaches in general and physical factors in particular is the subject of many years of discussion for them. One of the main places in the pharmacotherapy of osteoarthritis is occupied by nonsteroidal anti-inflammatory drugs, while our interest is associated with a group of so-called topical drugs.
AIM: In order to methodically substantiate the application of the magnetophoresis technology of the topical form of nimesulide in an experimental study, the influence of the magnetic field on the spectroscopic and thixotropic characteristics of the drug was determined, and the clinical efficacy of the combined use of magnetotherapy and the transdermal form of nimesulide in comparison with the application of the drug and magnetic therapy with a pulsed low-frequency magnetic field was determined.
MATERIAL AND METHODS: A randomized study involving 60 patients with osteoarthritis of the knee joints was performed. The experimental part of the study on the effect of the magnetic field on the structure and properties of the gel form of the preparation containing 1% nimesulide (chemical formula: 4'-nitro-2'-phenoxy-methane sulfonanilide) was carried out in laboratory conditions. The clinical part of the study included the use of local therapy (application of nimesulide gel in an amount of 24 g) to the skin in the knee joint area, followed by the placement of inductors of the ALMAG+ magnetic therapy apparatus on the medial and lateral surfaces of the knee joint. The impact was carried out according to the recommended "3+1" program.
RESULTS: An analysis of the effectiveness of therapy conducted in a group of 60 patients with osteoarthritis of the knee joints showed high efficiency, expediency and safety of the use of the technology under study in the treatment of patients with joint diseases.
CONCLUSION: Due to the synergistic effect on the pathogenesis of articular syndrome, the gel form of nimesulide and the magnetic field have a unidirectional effect: anti-inflammatory, decongestant, analgesic, microcirculatory. In addition, the magnetic field enhances the absorption and flow of the drug into the tissues, being a physical enhancer (amplifier), which significantly affects the result of treatment.
Reto demográfico y la imagen de Cervantes
Authors:   Universidad de Castilla-La Mancha, López Ruiz Víctor Raúl , Nevado Peña Domingo
Published: January 2023

La VI edición de la Semana Universitaria y Cervantina en honor al cronista e hijo predilecto de la Villa de Quero: Alfonso Ruiz Castellanos ha tenido lugar durante los días 19 al 24 de abril, bajo la marca de calidad Querote22, con dos congresos, uno científico de transferencia en la lucha ante el reto demográfico y el otro abre el catálogo de cursos de verano y extensión universitaria de la UCLM en 2022. Fruto de esta ya acreditada y singular semana se presenta este trabajo coordinado por los profesores Dr. Víctor Raúl López y Dr. Domingo Nevado que quiere dar visibilidad al evento a través de la herramienta, en la lucha sobre el reto demográfico, del desarrollo endógeno junto a la imagen percibida de Cervantes. Recogemos las ponencias del Congreso de Investigación para el Reto Demográfico (ISEN_RED22), junto con una selección de investigaciones noveles de los estudiantes de la UCLM presentadas al ISEN_RED22 sobre despoblamiento y el medio rural. Posteriormente son las ponencias del Congreso Cervantino Nacional las que muestran el avance sobre la imagen percibida de Cervantes. Por último, podremos disfrutar de los dos relatos premiados en el IV Certamen de Relatos.
Radical Leftist Latin American Regimes in Joe Biden's Foreign Policy
Authors: Rozental Dmitry M.
Published: January 2023

The article is devoted to the attempts of the Joe Biden’s administration to normalize relations with the radical leftist regimes (Cuba, Venezuela and Nicaragua). At the same time, the negotiation process is complicated by bureaucratic and ideological difficulties. The purpose of the study is to identify key obstacles of the improving the interaction between Washington and the antagonist countries. The author will analyze the main trends in the foreign policy of the United States in the region, as well as the behavior of the governments of Latin American countries. The results of the investigation will contribute to a better understanding of inter-American relations and will determine the trajectory of the transformation of the White House's course in the Western Hemisphere.
Oktatási módszerek az általános iskolások körében, a Covid-19 járvány idején
Authors: Kukucska Zsuzsa
Published: January 2023

The research focuses on the effects of the Covid-19 epidemic among primary school children, the transformations of the educational framework, within the study focuses on pedagogical perspectives. Mandatory online education frameworks have drawn attention to the differences between classroom lessons and digital teaching, the background dimensions of the teaching profession, which can also be interpreted as challenges in today’s education system. Accordingly, the study reflects the social and mental problems generated by the pandemic, the digitalisation that has become necessary in the field of education, the difficulties in the delivery of curricula affecting teachers, that is the pedagogical state of emergency and quarantine pedagogy. A pedagogical database teaching in small and large cities provides a basis for changes in teaching methods (n = 12). As a result, they have been able to present school-specific cases of online education, efforts to deliver digital learning materials, along with the difficulties in many cases and the innovations that can be incorporated later.
Perlindungan Hukum Bagi Konsumen Muslim Terhadap Kehalalan Produk
Authors: Andini Pratiwi Pusphito
Published: January 2023

Pasal 4 Undang- Undang Nomor 33 Tahun 2014 Tentang Jaminan Produk Halal merupakan salah satu regulasi mengenai kehalalan suatu produk. Pada fakta dilapangan masih ada beberapa produk atau komposisi-komposisi yang masih bisa lolos uji kehalalan meskipun produk atau komposisi tersebut tidak halal. Permasalahan yang berkaitan dengan perlindungan konsumen muslim, bahwa pada produk makanan dan minuman yang berlabel halal adalah untuk melindungi konsumen dan hak-hak konsumen muslim terhadap produk yang tidak halal. Memberikan kepastian hukum kepada konsumen muslim bahwa produk makanan dan minuman tersebut benar-benar halal sesuai yang disyariatkan oleh Hukum Islam. Terdapat beberapa Pasal yang berkaitan dengan kehalalan produk makanan yaitu Pasal 97 ayat (1), (2) dan (3) Undang-undang Nomor 18 Tahun 2012 tentang Pangan. Dalam memberikan perlindungan kepada konsumen, pengaturan tentang sertifikasi halal juga terdapat dalam dalam Pasal 23 sampai Pasal 27 Undang-Undang Jaminan Produk Halal yang mengatur tentang hak serta kewajiban pihak pelaku usaha dalam menghasilkan produk makanan halal, tidak hanya menyangkut mengenai produk makanan halal saja, tetapi juga terdapat pengecualian kepada pihak pelaku usaha yang memproduksi makanan dari bahan yang diharamkan dengan kewajiban memberikan label tidak halal pada bagian kemasan makanan yang mudah dilihat dan sulit terhapus. Dalam Undang-Undang Perlindungan Konsumen  terdapat dua jenis sanksi yang diancamkan kepada pelaku usaha yang melanggar. Sanksi-sanksi ini dibedakan dalam dua kategori, yaitu sanksi administrasi yang diatur dalam Pasal 60 Undang-Undang Perlindungan Konsumen dan sanksi pidana pokok, yang diatur dalam Pasal 61 Undang-Undang Perlindungan Konsumen.
THORACIC CT-SCAN WITH EGFR MUTATIONS IN PULMONARY ADENOCARCINOMA PATIENTS WITH PULMONARY METASTASES AT DR. MOEWARDI HOSPITAL, SURAKARTA, INDONESIA
Authors: Viska Wahyu Arianti  , Widiastuti Soewondo  , Sulistiyani Kusumaningrum  , Muhammad Lukman Hermansyah  , Yusup Subagio Sutanto  , Hari Wujoso
Published: January 2023

Highlights

The thoracic CT scan can be an alternative evaluation before administering EGFR-targeting medicine to patients.
EGFR is now a therapeutic target for lung cancer.

 
Abstract
Background: EGFR mutation is one of the molecular markers associated with prognosis and therapy in lung adenocarcinoma patients, including with lung metastases. The predominant imaging modality for assessing lung cancer is a chest CT scan, which correlates with prognosis. Objective: This study aimed to explore the association between characteristics of lung adenocarcinoma based on chest CT-Scan and EGFR mutation in lung adenocarcinoma with lung metastases. Material and Method: This study involved 65 lung adenocarcinoma patients in Dr. Moewardi Hospital, Surakarta, Indonesia, from January 2018-December 2020. Result: Chest CT-Scan and EGFR mutation were assessed in all subjects. EGFR mutation was found in 32 (49.8%) subjects. The risk of EGFR mutation was found to be higher in patients with lung adenocarcinoma who had lung metastases in a peripheral location (OR=11.56; 95%CI 3.57-37.33; p<0.001), tumor size <4 cm (OR=8.00; 95%CI 2.64-24.22; p<0.001), and semi-solid density (OR=5.21; 95%CI 1.79-15.19; p=0.002). Conclusion: EGFR mutation is associated with tumor location, size, and thickness based on chest CT-Scan in lung adenocarcinoma with lung metastases patients.
BODY MASS INDEX WITH SYSTOLIC AND DIASTOLIC BLOOD PRESSURE AT A PUBLIC HEALTH CENTER IN SURABAYA, INDONESIA
Authors: Bella Patricia Simanjorang  , Florentina Sustini  , Sundari Indah Wiyasihati
Published: January 2023

Highlights1. The Body Mass Index (BMI) measures how much fat the body carries.2. Obesity and overweight are characterized by an excessive buildup of fat that may be detrimental to health.
AbstractBackground: Body Mass Index (BMI) is an indicator of body fat. It is classified as underweight, normal, overweight, and obese. Obesity is a risk factor for hypertension (systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg). Objective: To analyze the correlation between BMI with systolic and diastolic blood pressure. Methods: This was an observational research with a cross-sectional design, and the samples consisted of 60 individuals aged 35 to 59 selected using accidental sampling. Blood pressure was the dependent variable whereas BMI was the independent variable. Data were analyzed using Pearson and Spearman correlation tests. Results: There were 44 females (73.3%) and 16 males (26.7%). The largest age groupings were between 45-49 and 50-54 years (31.7%), while the smallest was between 55-59 years (5%). Thirty-three samples (55%) were overweight (>25 kg/m2), 32 samples (53.4%) had systolic blood pressure above normal (≥120 mmHg), and 42 samples (70%) had diastolic blood pressure above normal (≥80 mmHg). The Pearson correlation test between BMI and systolic blood pressure showed a weak correlation (p=0.009 r=0.336). The Spearman correlation test between BMI and diastolic blood pressure showed a weak correlation (p=0.013 r=0.321). Conclusion: There was a weak correlation between BMI with systolic blood pressure, and there was a weak correlation between BMI with diastolic blood pressure in this study.
MOLECULAR DOCKING OF CROCUS SATIVUS PHYTOCHEMICALS AGAINST INDUCIBLE NITRIC OXIDE SYNTHASE AND PHOSPHODIESTERASE-9 IN HEART FAILURE PRESERVED EJECTION FRACTION
Authors: Yasmine Syafira , Firmanto Neissya Nastiti , Sabrina Annisa Maya , Khaerunnisa Siti
Published: January 2023

Highlights1. Heart failure preserved ejection fraction increases the mortality rate every year.2. Definitive therapy for HFpEF is not well identified.3. Crocus sativus phytochemical has anti-inflammatory and cardioprotective effects due to iNOS and PDE-9 inhibition.
AbstractBackground: Heart failure preserved ejection fraction (HFpEF) is a complex disease associated with metabolic disease as a risk factor. A previous study found an association between iNOS and PDE-9 with inflammation and myocardial fibrosis in HFpEF. Objective: This study aimed to identify the potential phytochemicals of Crocus sativus (Saffron) that can inhibit protein iNOS and PDE-9 based on a molecular docking study. Material and Method: A total of fifty phytochemicals were obtained from Dr. Duke’s Phytochemical Database and IJAH IPB. Those phytochemicals were screened by using the PyRx application and followed with Lipinski’s Rule of Five screening by using SWISS Adme. Ten phytochemicals with lowest binding energy for each protein were docked and visually analyzed using Autodock 4.2 and BIOVIA Discovery Studio Visualizer 2016. Results: The best binding energy between protein-phytochemicals were -9.17 kcal/mol and -8.55 kcal/mol for iNOS and -9.17 kcal,/mol and -9.08 kcal/mol for PDE-9. Conclusion: Delphinidine and malvidin are the recommended inhibitors against iNOS and PDE-9 and must be investigated in further research.
INSULIN THERAPY IN T2DM PATIENTS IN DIABETES OUTPATIENT CLINIC, DR. SOETOMO GENERAL ACADEMIC HOSPITAL, SURABAYA, INDONESIA
Authors: Dyah Rahadini Adinda Ayu , Murtini Sri , Soehita Sidarti
Published: January 2023

Highlights1. The occurrence of macrovascular and microvascular problems is strongly associated with high mortality in type 2 diabetes mellitus (T2DM).2. Combinations of rapid-acting and long-acting insulin were the most frequent kind of insulin.
AbstractBackground: High mortality in type 2 diabetes mellitus (T2DM) has a strong correlation with the presence of macrovascular and microvascular complications. The risk of these complications can be reduced through good glycemic control. As the disease progresses, patients may need to add or switch to insulin therapy rather than oral antihyperglycemic drugs to achieve desirable glycemic control. Objective: To determine the pattern of insulin therapy and glycemic control in T2DM patients. Material and Method: Data for this study were obtained from the medical records of the Diabetes Outpatient Clinic at the Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. This study was an observational descriptive. In June-July 2016, total samples were collected from 124 patients who received insulin therapy between February 2015 and March 2015. Result: According to the data obtained, the most commonly used insulin was a combination of rapid-acting and long-acting insulin (75.8%). While basal bolus insulin (75.8%) accounts for the most common regimen used to administer insulin, only 27.4% and 45% of total patients achieved good glycemic control based on FPG and PPG testing, respectively. HbA1c testing was done on 44 out of 124 people, with 9 people (20.5%) met the target of HbA1c <7%. Conclusion: Glycemic control in T2DM patients who received insulin therapy was relatively low.
CLINICAL PROFILE OF TYPE-1 DIABETES PEDIATRIC PATIENTS IN DR. SOETOMO GENERAL ACADEMIC HOSPITAL SURABAYA: CORRELATION OF GROWTH STATUS AND METABOLIC CONTROL
Authors: Grawira Drana Putra Respati  , Muhammad Faizi  , Agung Pranoto  , Mia Ratwita Andarsini
Published: January 2023

Highlights1. Diabetes mellitus type 1 (DM) is a chronic autoimmune illness characterized by insulin insufficiency and hyperglycemia as a consequence.2. Stable HbA1c levels may be indicative of improved growth rates.
AbstractBackground: Type-1 diabetes mellitus (DM) is a chronic auto-immune disease characterized by insulin insufficiency and resultant hyperglycemia caused by the destruction of insulin-producing beta cells in the pancreas. Metabolic control in type-1 DM affects the metabolism of patients, one of which is growth status, which is influenced by growth hormone. Improved growth rates can indicate stable HbA1c levels. However, whether growth is affected by the degree of diabetic control is still debatable. Objective: This study was conducted to determine whether the metabolic control correlates with growth status of children with type-1 diabetes in the Endocrine Polyclinic at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Material and Method: Retrospective observational analysis with a cross-sectional method was conducted on 96 type-1 DM patients at Dr. Soetomo General Academic Hospital Surabaya, Indonesia. The analysis was carried out using Chi-Square test to determine whether there was a correlation. Result: From a total of 96 pediatric patients, the majority was male (54.1%), patients with high-risk metabolic control were 79.2%, and those with z-score normal category were 62.5%. The results indicated no significant correlation between growth status and metabolic control of pediatric patients, with Chi-Square test results showed p=0.421 (p>0.05). Conclusion: There was no significant correlation between growth status and metabolic control of type-1 diabetes pediatric patients at the Endocrine Polyclinic Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
Validitas Booklet Sebagai Bahan Ajar Konsep Animalia (Bekantan)
Authors: Hafizah Ghina , Mahrudin Mahrudin , Irianti Riya
Published: January 2023

Konsep Animalia merupakan materi Biologi yang diajarkan di SMA kelas X berdasarkan Kurikulum Revisi 2013, dimana salah satu materi pokok yang diajarkan yaitu ciri-ciri umum hewan vertebarata (rangka tubuh, ruang jantung, reproduksi, suhu tubuh, dan penutup tubuh). Berdasarkan survey di SMA Negeri 1 Tamban, pembelajaran yang dilakukan pada konsep animalia masih menggunakan sumber belajar berupa buku teks yang membuat peserta didik kurang antusias. Tujuan penelitian untuk mengembangkan booklet konsep animalia yang kemudian disesuikan dengan kebutuhan serta Rencana Pelaksanaan Pembelajaran materi biologi. Booklet divalidasi oleh validator yaitu 2 orang dosen Pendidikan Biologi dan 1 orang guru mata pelajaran Biologi. Berdasarkan penilaian oleh validator, booklet yang dikembangkan sudah baik dan valid untuk digunakan dalam penunjang pembelajaran pada konsep animalia terlebih pada sub bab vartebrata.
KH. Muhammad Rosyad: Pendakwah Islam di Kecamatan Martapura Kota Kabupaten Banjar Tahun 1939-2000
Authors: Perdana Muhammad Putra Wahyu , Sriwati Sriwati , Mansyur Mansyur
Published: January 2023

South Kalimantan is a province where the majority of the population holds strong Islamic teachings. This is evidenced by the large number of ulama who are scattered in almost all areas in South Kalimantan, therefore the Banjar community is known as a strong community holding the religion of Islam because of the existence of ulama who have influence and a large role in society. The research objective was to describe the biography of a ulama from Martapura named KH Muhammad Rosyad and to explain his role as a ulama in Martapura Subdistrict Kota Banjar Regency in 1939-2000. The research method used is the historical method. The steps taken in this research are heuristics or data collection through the interview method. The second stage is data criticism. The third stage is interpretation, and the last stage is historiography, namely writing the research results. The results showed that KH Muhammad Rosyad was born from the marriage of KH. Ahmad Zaini and Hj. Noorjanah on April 15, 1939, and died on Thursday, June 8, 2000 at the age of 63. The role of KH Muhammad Rosyad in preaching is that he opens a routine recitation every Wednesday night. He is also a lecturer at the Darussalam Martapura Islamic Boarding School, Datu Kalampayan Bangil and the College of Sharia Sciences. He is one of the scholars whose words and actions are in harmony in fostering the ummah, this is evidenced by him establishing a financial institution called BMT Al-Karomah Martapura Sharia Cooperative which still exists today with the aim of helping the economy of the people, especially the people of Martapura.
IDENTIFYING AND ANALYZING THE RISK FACTORS OF SUSTAINABLE SUPPLY CHAIN MANAGEMENT IN TEXTILE SECTOR
Authors: YONTAR Emel , ZENGİN Şölen
Published: January 2023

Sustainable supply chain management is a management process that combines economic, social and environmental contribution and foresees making certain decisions and planning at every stage of the supply chain line. With the understanding of sustainable management style, companies keep environmental traceability in the foreground, provide necessary regulations, take important steps in social environment cooperation and achieve economic efficiency while doing all these. In addition to the economic investments required to make their supply chains more effective with a developing sustainability understanding, companies should also consider the risks that environmental and social factors may bring, taking into account the level of uncertainty in the future and their decisions. While the risk factor is accepted as the uncertainty associated with the occurrence of any event; on the other hand, risk management is strategically important in the planning of contingencies. Risk management in the supply chain is effective in identifying and analyzing risk factors in the economic and production cycle and in producing proactive solutions against risks. With the effect of the rapidly increasing population of the world, there is a significant increase in textile consumption. In this study, for risk assessment in sustainable supply chain management for the textile sector; covered under the main headings of supply, production, distribution, customer, reverse logistics and within the framework of economic, social and environmental subheadings. Potential risks are determined by reviewing the literature and taking opinions from textile sector employees. As a result of the study, it is aimed to develop a comprehensive framework for Sustainable Supply Chain Risk Management (SSCRM). Important strategies such as the ability to transform textile wastes into the raw materials of value-added products with appropriate technologies, which are included in the sustainability of textiles, are presented.
Roma 1935: arquitectura, ciudad, retórica y propaganda en el Congreso Internacional de arquitectos = Rome 1935: Architecture, City, Rhetoric and Propaganda in the International Congress of Architects
Authors: Alonso Pereira José Ramón
Published: January 2023

AbstractThe period 1922-1943 —the so-called fascist venthenium— was a fruitful and creative time in Italian architecture. Its rich and plural fundamentals established singular relationships between classical and modern cultures, which transcends their historical moment and present new topics for analysis and reflection. To know and appreciate its architecture, we will use the journeys of the professionals who came to Rome from all over the world to participate in the International Congress of Architects in 1935, considering the Congress as a space of opportunity for that reflection, and taking the visits around Rome scheduled by the organizers as a source of the architectural and urban interests of its time, and a reflection of the trends that were stirring then in Italy.ResumenEl periodo entre 1922 y 1943 —el llamado ventenio fascista— fue una época fecunda y creativa en la arquitectura italiana. Sus bases ricas y plurales establecieron relaciones singulares entre el mundo cultural clásico y el moderno, que trascienden su momento histórico y plantean en nues-tros días nuevos temas de análisis y reflexión. Para conocer y valorar su arquitectura y su modelo urbano, nos serviremos del viaje al que fueron llevados los profesionales que de todo el mundo llegaron a Roma para participar en el Congreso Internacional de Arquitectos en 1935, considerando el Congreso como un espacio de oportunidad para esa reflexión y tomando las visitas a la ciudad programadas por los organizadores como fuente de los intereses arquitectónicos y urbanos de su tiempo, reflejo de las tendencias que se agitaban entonces en Italia.
Freeform Auxetic Mechanisms Based on Corner-Connected Tiles
Authors: Warisaya Kanata , Sato Jun , Tachi Tomohiro
Published: January 2023

Auxetic mechanisms based on corner-connected polygonal tiles have been used to design deployable structures and are currently applied to programmable surfaces. However, existing surface structures are realized by compliant kirigami, and the realization with rigid-body mechanism, in
particular with thick panels, is still limited to configurations with global symmetries due to the mechanism's overconstraining nature. In this study, we generalize the auxetic mechanisms into freeform surfaces by imposing local symmetries on polyhedral surfaces. From the discussion of kinematics,
we show that polyhedral surfaces whose edges coincide with a Voronoi diagram of points on the surface can be converted to kinematics systems of corner-connected kinematic tiles. We propose hard constraints to ensure the Voronoi property required for the kinematics and soft constraints to attain
a large expansion ratio. Then, we provide an optimization-based scheme using the proposed constraints to achieve a mechanism from a given target surface. We also propose methods for accommodating the thickness of the tiles and show different variations of joints. As a result, we obtained deployable
surfaces of positive and negative Gaussian curvature that can deploy and contract with a one-DOF mechanism. If the structure is viewed as a cellular material, it has an auxetic property with Poisson's ratio of -1. It is also potentially scalable to architectural applications because our mechanism
is composed of rigid bodies and hinges.
A Duality Principle and a Concerning Convex Dual Formulation Suitable for Non-convex Variational Optimization
Authors: Botelho Fabio
Published: January 2023

This article develops a duality principle and a related convex dual formulation suitable for a large class of models in physics and engineering. The results are based on standard tools of functional analysis, calculus of variations and duality theory. In particular, we develop applications to a model in non-linear elasticity.
Identification Of A New Role Of miR-199a-5p As Factor Implied In Neuronal Damage: Decreasing The Expression Of Its Target X-Linked Anti-Apoptotic Protein (XIAP) After SCI.
Authors: Muñoz-Galdeano Teresa , Reigada David , Gamarra María , Soto Altea , Barreda-Manso María Asunción , Novillo Irene , Nieto-Díaz Manuel , Maza Rodrigo M.
Published: January 2023

Altered expression of microRNAs (miRNAs) after spinal cord injury (SCI) has been described as being responsible for the main secondary responses, such as apoptosis. X-linked inhibitor apoptosis protein (XIAP) is a key apoptotic component involved in the progression of apoptotic programmed cell death. Several regulators have been described to modulate the XIAP's function, including the post-transcriptional regulator's miRNAs. The main aim of the present work is to identify miRNAs with altered expression after SCI which can regulate XIAP expression. Our bioinformatic analyses identified several candidate miRNAs that may regulate XIAP, among which miR-199a-5p may be involved in the downregulation of XIAP after SCI. Gene reporter assays and in vitro analyses in the neural C6 cell line confirmed the targeting of miR-199a-5p on the 3-UTR of the rat XIAP and its post-transcriptional regulation of XIAP protein level, but not at mRNA level. Analyses in a rat model of SCI revealed a trend towards increased expression of miR-199a-5p and a decrease in XIAP protein level at 3 days after injury. Finally, using a specific fluorescent in situ hybridization (FISH) probe for miR-199a-5p, we characterized the expression pattern of miR-199a-5p in cells of uninjured and rat-contused spinal cords. These findings provide new insights into apoptotic miRNA-mediated mechanisms after SCI, which will help us develop therapeutic strategies based on miRNAs for treating SCI.
Urate-Lowering Therapy Use Among US Adults with Gout and the Relationship Between Gout Treatment Status and Associated Comorbidities
Authors: Ortiz-Uriarte Marcos , Betancourt-Gaztambide Jeanlouis , Perez Rivera Alexandra , Roman Youssef Malak
Published: January 2023

Introduction: Individuals with gout are at higher risk of developing chronic conditions, such as diabetes, chronic kidney disease (CKD), and cardiovascular diseases. In this study, the association between urate-lowering therapy (ULT) use and the prevalence of these conditions was evaluated.
Methods: This observational, cross-sectional pharmacoepidemiologic study used the 2013-2018 biannual cycles of the National Health and Nutrition Examination Survey. The inclusion criteria were adults 30 years of age and older with a diagnosis of gout. The association between ULT treatment status and dyslipidemia, coronary heart disease, heart failure, hypertension, and chronic kidney disease was evaluated, as well as associations with select clinical laboratory biomarkers.
Results: Use of ULT was 28.9% (95%CI 24.3%-33.9%). There was no significant association between ULT use and the prevalence of heart failure, coronary heart disease, hypertension, or dyslipidemia (p>0.05). Those on ULT had a lower mean eGFR compared to those not on treatment (68.03 versus 74.74 mL/min/1.73m², p=0.014). LDL- and HDL- and total cholesterol were significantly lower among those receiving ULT treatment (p<0.05).
Conclusion: ULT use continues to be low among those with gout. Those on ULT were more likely to be diagnosed with CKD, college graduates and above, older males, and obese. Clinical guidelines conditionally recommend ULTs in co-morbid kidney disease; while our results may reflect guidelines recommendation for ULT use in CKD patients, worsening kidney function while taking ULT is unlikely. Further research is necessary to determine the long-term impact of ULTs on kidney function and cardiovascular biomarkers.