bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Civilian Aggravating Factors on the Military Death Penalty (1984-2005): Another Chapter in the Resistance of the Armed Forces to the Civilianization of Military Justice
Authors: Grosso Catherine , Baldus David , Woodworth George
Published: May 2022

In 1984, the U.S. Armed Forces amended its capital punishment system for death eligible murder to bring it into compliance with Furman v. Georgia. Those amendments were modeled after death penalty legislation prevailing in over thirty states. After a brief period between 1986 and 1990, the charging decisions of commanders and the conviction and sentencing decisions of court martial members (jurors) transformed the military death penalty system into a dual system that treats two classes of death eligible murder quite differently. Since 1990, a member of the armed forces accused of a killing a commissioned officer or murder with a direct impact on the ability of military commanders to run an effective and disciplined military is significantly more likely to face a capital court martial and be sentenced to death than a similarly situated member accused of a murder connected to the military only fry the identity of the accused.

This empirical study of charging and sentencing decisions in 104 death eligible military murders from 1984-2005 documents contemporary resistance to the civilianization of the military death penalty as manifest in charging and sentencing decisions. We conclude that a limitation of death eligible murder to those directly impacting military command and control could reduce the risk of arbitrariness in the administration of the military death penalty.
Once More Unto the Breach: American War Power and a Second Legislative Attempt to Ensure Congressional Input
Authors: Menitove Jonathan
Published: May 2022

Once again embroiled in an unpopular overseas armed conflict, the United States faces difficult questions concerning the constitutional use of military force. Records from the Constitutional Convention suggest the Framers intended to lodge America's power to go to war with the Congress. While American presidents' early use of military force displays deference to the legislature, more recent military actions illustrate the executive's dominance in making war. Notwithstanding a few early court decisions in Congress 's favor, the judiciary has been unhelpful in restoring the constitutional Framers' vision for the administration of the war power Congress, therefore, has been forced to act alone in attempting to revive the legislature's role in the decision to go to war After several unsuccessful attempts, Congress's passage of the War Powers Resolution of 1973 appeared to finally re-inject congressional input in the war-making process. However subsequent jurisprudence, scholarly debate, and presidential disregard for the law have revealed the War Powers Resolution's various inadequacies. Accordingly, this paper proposes that a new law-the War Powers Appropriations Act-be passed to protect the congressional war powers afforded by the Constitution. By protecting Congress's role via the legislature's constitutional power to appropriate funds, the War Powers Appropriations Act represents a solution that accomplishes the goal of forcing the executive to consult with Congress, while avoiding the potential pitfalls of unconstitutionality, inartful drafting, and presidential disregard.
Turning a Short-Term Fling into a Long-Term Commitment: Board Duties in a New Era
Authors: Grossman Nadelle
Published: May 2022

Corporate boards face significant pressure to make decisions that maximize profits in the short run. That pressure comes in part from executives who are financially rewarded for short-term profits despite the long-term risks associated with those profit-making activities. The current financial crisis, where executives at AIG and numerous other institutions ignored the long-term risks associated with their mortgage backed securities investments, arose largely because those executives were compensated for the short-term profits generated by those investments despite their longer-term risks. Pressure on boards for short-term profits also comes from activist investors who seek to make quick money off of trading in stocks whose prices overly reflect short-term firm values.

Yet this excessive focus on producing short-term profits runs counter to the interests of non-short-termist investors, other corporate constituents, as well as our economy and society as a whole in creating corporate enterprises that are profitable on an enduring basis. Once again, the current financial crisis provides a lens through which we can see the distressing impact-both to individual businesses as well as to the entire US community-of an excessive focus on short-term profits.

I propose a solution to address this problem of short-termism. Under my proposal, directors would be required to make decisions that are in the long-term best interest of stockholders and the corporation under their fiduciary duties. I explain in the Article why I propose fixing the short-termism problem through fiduciary duties as well as how, practically, my proposal would be implemented.
ИНТЕРАКТИВНЫЕ ТЕХНОЛОГИИ КАК ЭФФЕКТИВНОЕ СРЕДСТВО ИЗУЧЕНИЯ ФОЛЬКЛОРА НА УРОКАХ ЛИТЕРАТУРЫ
Authors: Бибаева А.А. , Мамалова Х.Э.
Published: May 2022

В статье рассмотрены интерактивные технологии как эффективное средство изучения фольклора на уроках литературы. Важнейшей задачей литературного образования в школе является приобщение обучающихся к искусству родного слова, и при реализации данной задачи роль фольклора трудно переоценить. Поскольку раздел «Устное народное творчество» был и по-прежнему остаётся самым традиционным, «незыблемым» в школьном курсе литературы, в том числе в основной школе, современный подход требует пересмотра его не столько со стороны содержания, сколько со стороны способов его изучения. Одним из эффективных средств организации изучения фольклора на уроках литературы являются интерактивные технологии. Анализ теоретической литературы показывает, что в настоящее время в научной среде не выработано общепринятого определения термина «интерактивные технологии». При определении понятия «интерактивные технологии» исследователи исходят из двух возможных интерпретаций: одни понимают их в более узком, «инструментальном» смысле – как передовые информационные технологии, другие трактуют данное понятие более широко, подразумевая под интерактивными технологиями любого рода обучающие технологии, предполагающие равноправие участников образовательного процесса и их активное участие в этом процессе.
ОСОБЕННОСТИ ОРГАНИЗАЦИИ ВНЕУРОЧНОЙ ПОЗНАВАТЕЛЬНОЙ ДЕЯТЕЛЬНОСТИ ОБУЧАЮЩИХСЯ ШКОЛЫ
Authors: Зузиева С.А. , Закраилова Б.Р.
Published: May 2022

В статье раскрыто содержание понятия «внеурочная познавательная деятельность» – одного из основных компонентов образовательного процесса и одной из форм организации свободного времени обучающихся, которая направлена на решение задач их воспитания и социализации. Рассмотрены принципы и особенности организации внеурочной познавательной деятельности на уровне начального общего образования: отсутствие постоянного контроля результатов детей, что позволяет создать более комфортную, спокойную среду для обучающегося, формирует отношение равноправия между обучающимся и учителем; содержание внеурочной деятельности построено с учетом интересов, желаний, потребностей школьников, родителей, учителей; внеурочная деятельность позволяет в большей степени раскрыться таланту обучающихся, дает возможность проявить инициативу на занятиях; внеурочная деятельность носит добровольный характер; содержание внеурочной познавательной деятельности основывается на исследовании интересов и потребностей обучающихся различного возраста; широко используются разнообразные формы, средства и методы воспитательной работы; используется различное образовательное пространство (актовые, спортивные залы, места для прогулок, экскурсий и т.д.); привлечение родителей, обучающихся старшей и средней школы для передачи опыта социальной жизни; внеурочная деятельность может быть реализована в каникулярное время, выходные дни.
ПРИМЕНЕНИЕ ИНТЕРАКТИВНЫХ ТЕХНОЛОГИЙ В СОВРЕМЕННОЙ ШКОЛЕ
Authors: Каимова П.И. , Сельмурзаева Х.Р.
Published: May 2022

В статье проведен анализ литературы по проблеме применения интерактивных технологий в современной школе. Нередко в работах одного и того же учёного наблюдается смешение понятий «интерактивные технологии» и «интерактивное обучение», что представляется неправомерным и не способствует выявлению истинной сущности такого феномена, как интерактивные технологии. Под интерактивным обучением нами понимается особым образом организованная познавательная деятельность, при которой предполагается равная степень задействованности всех участников образовательного процесса. Проведённое исследование показало, что хотя сегодня интерактивные техники и приёмы применяются в педагогической практике очень часто, сам «спектр» этих техник и приёмов крайне однообразен. Роль школы в условиях меняющихся требований к качеству образования возрастает. Для успешной самореализации и социализации обучающийся должен научиться не только приобретать и транслировать полученные знания, но и уметь рефлексировать над ними, делать собственные выводы и порождать новые идеи. Интерактивные технологии, предполагающие активность каждого субъекта образовательного процесса, способны помочь в решении этих задач.
THE ROLE OF PARAMETRISM IN MODERN ARCHITECTURE
Authors: Nilufar Khikmatullaeva
Published: May 2022

The article examines the history of the emergence and stages of development of Parametrics. The origins of this method, its specific features, main tasks and sources of information for design are studied. The main problems in the development of the application of parametricity in buildings and structures in Uzbekistan are covered.
KEY WORDS: parametric architecture, parametric design, parametricism, Zaha Hadid, Patrick Schumacher.
ACHIEVING ECONOMIC DAMAGE WHEN USING MEANS OF DESTABILIZATION OF ELECTRIC POWER SYSTEMS
Authors:   Financial University under the Government of the Russian Federation, Moscow, Russia, Kosenok Yuri N. , Romanchenko Leonid N. ,   Financial University under the Government of the Russian Federation, Moscow, Russia
Published: May 2022

The critical state of the electric power industry has become more and more evident not only in Ukraine, but throughout Europe. The exploitation of its technical potential, ignoring the need to upgrade obsolete generating capacities and equipment of the power grid, reckless incentives for green energy, voluntaristic attempts to reform the electricity market, illogical tariff policy - all this led to chaos in the industry. There is still no unambiguous understanding of how to get out of the critical situation, in which direction to develop the electric power industry, and which generating sources to focus on. Now the most urgent is the achievement of economic damage when using means to destabilize electric power systems during armed conflicts. The article considers the development prospects and the technical appearance of the means of destabilization of electric power systems, as the basis of economic and energy security.
AUDIT OF ORGANIZATIONAL PROCESSES AS A FACTOR OF SUSTAINABLE DEVELOPMENT OF ORGANIZATIONS
Authors:   Financial University under the Government of the Russian Federation, Moscow, Russia, Dvoretskaya Vera V. , Melnik Margarita V. ,   Financial University under the Government of the Russian Federation, Moscow, Russia
Published: May 2022

The article considers one of the modern directions of internal audit and control, the object of which is a communication model for the development of modern corporate entities. The main objects and subjects of audit and control of business processes, methods for ensuring their synchronism and consistency in making strategic, current and operational decisions taken during the development of new industries are determined, and the impact of the timeliness of identifying the risks of violation of consistency and methods for minimizing negative consequences are shown. The use of international management quality standards during the audit and control of business processes is shown. The main trends in the development of internal control and audit of business processes at different stages of the life of the finished product are determined.
METHODOLOGY OF COST ESTIMATION OF SUBSOIL USE LICENSES WITHIN THE FRAMEWORK OF THE COST APPROACH
Authors:   Financial University under the Government of the Russian Federation, Moscow, Russia, Konev Dmitry V.
Published: May 2022

The article discusses the methodology for determining the market value of a license for the right to use subsoil resources within the framework of a cost approach. This method is based on the calculation of the starting payment in the framework of auctions for the sale of licenses, taking into account the correction for the excess of the final auction price over the starting payment, determined on the basis of the analysis of the auction results. The methodology was tested on the basis of the evaluation of the license for the right to use the subsoil of the Novopetrovskoye field, developed by PJSC Polymetal.
Geometria Espacial nas questões do Enem
Authors: Santos de Oliveira Wellington Fabiano , Matesco Cristovão Eliane
Published: May 2022

Este artigo apresenta os resultados de uma pesquisa que investigou o perfil das questões sobre Geometria Espacial do Exame Nacional do Ensino Médio (Enem). Estas questões foram classificadas à luz da Teoria dos Níveis de Pensamento Geométrico de van Hiele. O corpus desta pesquisa, de natureza documental, é constituído pelos cadernos de questões do Enem de 2009 a 2019. Um levantamento de pesquisas, relacionadas ao ensino e à aprendizagem de Geometria Espacial, realizado no Catálogo de Teses e Dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, possibilitou sugerir recursos e abordagens para o ensino da Geometria Espacial a partir dos perfis e níveis das questões analisadas.
Relief and fossil weathering products in the surroundings of the town of Bruntál
Authors: Czudek Tadeáš
Published: May 2022

The author describes geomorphological features and relief development as well as fossil weathering products in the surroundings of the town of Bruntál (Northern Moravia) in the area built of Devonian and Lower Carboniferous rocks. Among other he arrived at the conclusion, that tectonics played, indeed, an important role in the landscape evolution. The planation surface is an exhumed and remodelled basal front of weathering. The faults and joint zones have considerably influenced the valley pattern. The basin of Bruntál began to develop already before the Badenian (Miocene). The mean rate of the incision of the Moravice-River valley in the Pleistocene was 7 cm per 1000 years.
La famille, l��cole, l��tat
Authors: Caspard Pierre
Published: May 2022

Dans les r�gions d�velopp�es de l�Occident moderne, les parents ont �t� nombreux � vouloir assurer � leurs enfants, gar�ons et fi lles, une bonne ma�trise de leur langue, parl�e, lue et �crite. Les raisons qui �taient les leurs, les moyens qu�ils se sont donn�s, les r�sultats qu�ils ont atteints, font l�objet du pr�sent livre.

Le contexte r�gional observ� est celui de l�actuel canton suisse de Neuch�tel. Les principes, valeurs et int�r�ts qui motivaient ses paysans, artisans, ouvriers, commer�ants, petits notables, � instruire ou faire instruire leurs enfants, se donnent � voir dans leurs �crits personnels, mais aussi dans les programmes de leurs �coles, dont ils d�cidaient collectivement, dans un contexte de d�mocratie directe exerc�e au niveau communal.

Par cette pratique de la d�mocratie directe, le pays de Neuch�tel appartient au monde helv�tique. Socialement et culturellement, il est proche aussi d�autres r�gions de l�Occident d�velopp�. Le livre propose diverses comparaisons avec la France mais invite, plus largement, � une r�flexion sur les politiques d�instruction men�es par des acteurs localement situ�s, avant que les �tats nationaux ne privil�gient une scolarisation g�n�ralis�e sous leur contr�le, dans le courant du XIXe si�cle.
Isofraxidin Protects BV2 Cells from Oxygen and Glucose Deprivation Injury via Regulating NF-κB/NLRP3 Pathway
Authors: Su Ying , Chen Yang , Hou Shuangxing , Ye Jun
Published: May 2022

Inflammation is a significant contributor to ischemic stroke. Isofraxidin has been demonstrated to play an anti-inflammatory role in different diseases. However, its role in cerebral ischemia injury still needs to be explored. Using BV2 cells subjected to oxygen and glucose deprivation as a model for cerebral ischemia injury, we have shown that isofraxidin treatment alleviates cell injury and apoptosis, reduces inflammation, and decreases oxidative stress by suppressing NF-κB/NLRP3 pathway.
Filosofía sostenible en tiempos de desarraigo
Authors: Fernández Bascones Elisa
Published: May 2022

Nuestro objetivo será reflexionar sobre la idea de arraigo haciendo referencia a autores tan relevantes como Heidegger o P. Sloterdijk. El sentido de la existencia humana necesita la profundidad de la tierra. La esencia del desarraigo reside en el hecho de convertirse en un extraño para la patria. Vamos a reflexionar sobre la técnica como posible causante del desarraigo actual. El arraigo se definirá como la posibilidad de estar cerca: cerca de uno mismo, cerca del Otro, cerca de la Tierra, cerca del futuro, cerca de la muerte. Esta proximidad podría recuperarse en la medida en que seamos capaces de redescubrir el sentido de las cosas.
PERBANDINGAN KUALITAS HIDUP PASIEN GAGAL GINJAL KRONIK DENGAN KOMORBID FAKTOR DIABETES MELLITUS DAN HIPERTENSI PADA PASIEN YANG MENJALANI HEMODIALISA
Authors: Rantepadang Andreas
Published: May 2022

Abstrak

Hipertensi dan Diabetes mellitus (DM) merupakan faktor komorbid yang berperan penting dalam peningkatan penderita Gagal ginjal kronik yang mengharuskan menjalani hemodialisa supaya kualitas hidup pasien Gagal ginjal kronik dapat dipertahankan atau ditingkatkan. Tujuan penelitian ini adalah menganalisa perbandingan kualitas hidup pasien gagal ginjal kronik dengan komorbid faktor Diabetes Melitus dan Hipertensi pada pasien yang menjalani hemodialisa. Metode penelitian observasional analitik dengan desain penelitian cross sectional, Populasi pada peneilitian ini adalah penderita Gagal ginjal kronik yang menjalani Hemodialisa di RSA Manado, penentuan sampel purposive sampling terdapat 43 sampel yang memenuhi kriteria penelitian, 23 responden komorbid Hipertensi dan 20 komorbid DM. Hasil penelitian didapatkan rata-rata kualitas hidup pada pasien Hemodialisa dengan komorbid DM 55.25 sedangkan pada pasien hemodialisa dengan komorbid hipertensi lebih tinggi yaitu 57.69 untuk hasil uji independent t test didapatkan nilai p-value 0.479 >0.05 yang menunjukkan tidak ada perbedaan yang signifikan kualitas hidup pada pasien Gagal ginjal Kronik dengan komorbid DM dan hipertensi. Kesimpulan: secara rata-rata kualitas hidup pasien Gagal ginjal kronik dengan komorbid Hipertensi lebih baik dibandingkan dengan komorbid DM tetapi secara statistik tidak signifikan. Saran: Diharapkan untuk penelitian selanjutnya untuk menambah jumlah sampel dan sampel yang seimbang antara kedua kelompok.
HUBUNGAN ASUPAN ENERGI DAN AKTIVITAS FISIK DENGAN DAYA TAHAN OTOT PADA ANAK
Authors: Saluy Priscillia Merylin , Supatman Ernando , Purnawinadi I Gede
Published: May 2022

Daya tahan otot merupakan kemampuan daya tahan seseorang untuk melawan kelelahan seperti lari, sit-up dan asupan energi serta aktivitas fisik merupakan indicator meningkatkan daya tahan otot. Sumber energi pada manusia dalam bentuk karbohidrat, lemak dan protein, tanpa asupan energi yang cukup setiap harinya, anak akan mengalami kelelahan mental serta fisik dan aktivitas fisik menyebabkan tubuh kelelahan atau kehabisan tenaga dan olahraga adalah salah satu aktivitas fisik. Tujuan penelitian ini adalah mengetahui apakah ada hubungan antara asupan energi dan aktivitas fisik dengan daya tahan otot pada anak kelas 4 dan 5 di SDN 2 Airmadidi. Penelitian ini menggunakan metode cross sectional dengan rumus pearson correlation. Pengumpulan data dilakukan pada bulan Februari 2017. Hasil penelitian menunjukkan asupan energi anak-anak normal yaitu 100,97%, klasifikasi aktivitas anak-anak sedang dan daya tahan otot lari 11.74 kali dan sit-up 21.28 kali. Hasil uji statistik menunjukkan ada hubungan asupan energi dengan daya tahan otot (sit-up)0.039<0.05 dengan kuat hubungan sedang, tidak ada hubungan asupan energi dengan daya tahan otot (lari) 0.890>0.05, tidak ada hubungan aktivitas fisik dengan daya tahan otot (sit-up) 0.084>0.05, dan tidak ada hubungan aktivitas fisik dengan daya tahan otot (lari) 0.107>0.05. Rekomendasi penelitian ini untuk pemenuhan asupan energi dan aktivitas fisik dapat diterapkan pada anak dalam masa pertumbuhan usia 8-12 tahun.

 

Kata kunci : Asupan Energi, Aktivitas Fisik, Daya Tahan Otot.
FAKTOR-FAKTOR PENENTU SEBAGAI DETERMINAN ANAK STUNTING DI INDONESIA
Authors: Anjani Sheira Indah
Published: May 2022

The prevalence of stunting in Indonesia continues to decline by 27.67% based on the results of the 2019 Indonesian Toddler Nutritional Status Study (SSGBI) which also shows that the stunting rate in Indonesian toddlers is quite far from the 20% standard set by WHO. The purpose of compiling this study is to identify the determinants of stunting in children due to the high prevalence of stunting in Indonesia. The method used in this study is an observational study and a systematic literature review. Searches were made with keywords in PubMed, PubMed Central (PMC), and Web of Science published from 2012 to present. Then, obtained 86 results from PubMed, 1,624 from PMC, and 69 from Web of Science and selected 15 studies deemed relevant. Proximal factors such as household factors, breastfeeding practices and complementary feeding, as well as distal factors such as infection and social environment are the determinants of stunting in Indonesia.
Research Project on the Real Effectiveness and Impact of Vaccination Against Rotavirus Diarrhea in DR Congo
Authors: Lungayo Christophe Luhata , Burke Rachel , Otomba John Samuel , Launay Odile , Jouffroy Romain
Published: May 2022

Vaccination is one of the most effective investments in public health. It contributes to the significant reduction of diseases and long-term disabilities [1]. Thus, several vaccines have been used for several decades in different countries. Their main expected impact is to significantly reduce mortality and morbidity due to the infectious diseases they target and thus save millions of human lives.
Association of Myocardial Infarction Among Cervical Cancer Patients
Authors: Armandani Reviandy Achmad , Irwanto Yahya
Published: May 2022

Introduction: Increased risk of myocardial infarction has been validated for several cancers, but limited study evaluated this risk in cervical cancer patients. Our study aimed to evaluate the risk of myocardial infarction in cervical cancer patients. Method: This study using systematic review that search using keyword myocardial infarction and cervical cancer in Google Scholar and PubMed. Result: After final screening the author analysize 2 articles. Conclusion: These study demonstrated cervical cancer patients had a higher risk of myocardial infarction than the general population, especially in younger patients. Most cancers were associated with an increased risk of MI during the first 6 months after diagnosis. MI risk was related to the presence of metastates. Cancer patients may need a more aggressive treatment of classical MI risk factors. Strategies to reduce this risk should be assessed.
COVID-19 Community Survey, Knowledge, Attitude and Practice by Bangladeshi Population
Authors: Jesmin Subrina , Maqbool Adil , Sohael Farzana , Islam Md Majedul , Matsuishi Yujiro , Shima Takeru , Shimojo Nobutake , Kawano Satoru , Rahman Md Arifur , Yamaguchi Naoto , Moroi Masao
Published: May 2022

Background: In a public health crisis, knowledge and understanding of disease transmission modes, fundamental hygiene concepts, and procedures are critical for designing effective control measures. The purpose of this research was to assess the Bangladeshi population's Knowledge, Attitude and Practice (KAP) towards COVID-19. Methods: A series of questions about the KAP of the population about COVID-19 were asked in this cross-sectional study, which was conducted among the general population of Bangladesh over the age of 15, and participants' demographic characteristics and source of information about COVID-19 were recorded and analyzed. Results: Despite the fact that the majority of respondents (more than 60%) had a positive attitude about COVID-19, 70% of those questioned in Bangladesh had insufficient understanding and preventative actions. This latter discovery is promising and suggests a potential therapeutic strategy. Male and less educated respondents reported inadequate COVID-19 preventive methods, as well as a lack of understanding about signs and symptoms and transmission. The findings revealed a substantial link between knowledge, attitude, and practice among women of a certain gender, age, and education level. Male gender, non-healthcare-related jobs, single status, and a lesser degree of schooling were all substantially correlated with poorer knowledge scores, according to multiple linear regression analysis. Conclusion: The present study revealed a high attitude among the study population towards COVID-19 but a poor response on knowledge and preventive practices, which can be enhanced by awareness campaigns and proper planning.
miR-497-5p Enhances the Chemosensitivity of Non-Small Cell Lung Cancer Cells to Cisplatin via Targeting of the CDCA4 Gene
Authors: Azam Nasir , Yang Shuo , Rahman Khalil Ur , Yu Jiawen , Zhao Chunhui , Feng Bin
Published: May 2022

Non-Small Cell Lung Cancer (N-SCLC) accounts for almost 85% of all diagnosed lung cancer and the prognosis remains poor usually because of assimilated drug resistance including cisplatin. The miR-497-5p family has been discovered to play a significant role in regulating biological functions in N-SCLC. The purpose of this study was to investigate the molecular mechanism of miR-497-5p and its target gene on modulating cisplatin chemosensitivity in N-SCLC cells. The enhanced chemosensitivity effect of miR-497-5p to cisplatin in A549 and H1299 cells was detected by MTT method. Dual luciferase reporter assay, quantitative Real-Time PCR (qRT-PCR) and Western blotting were performed to demonstrate that miR-497-5p directly targets CDCA4 to reduce the expression. Transwell, colony formation and ﬂow cytometry assays showed that combination of miR-497-5p and cisplatin exerted stronger effects on inhibiting N-SCLC cells proliferation, migration and invasion as well as promoting apoptosis and G1 phase arrest than miR-497-5p and cisplatin alone. The same tendency was observed in the upregulation of apoptosis-related protein Bax and Cytochrome-C and downregulation of cycle-related proteins CyclinB1 and CDK1. Our results indicate that upregulation of miR-497-5p targets CDCA4 directly and may function as an important modifier to sensitize N-SCLC cells to cisplatin.
Post-COVID Syndrome: Changing the Prognosis of Chronic Non-communicable Diseases
Authors: Jaramillo-Acosta Manuel Alejandro , Ramírez-Salgado Camilo Andres , Castillo Narvaez Natalia Andrea , Rahman Md Moshiur
Published: May 2022

Post-COVID-19 syndrome is defined as the persistence of signs or symptoms following the acute phase of COVID-19 [1], which may persist for an indeterminate period of time; or it is defined as the period of risk following the acute phase of COVID-19 [1], in which major complications may occur depending on organ injury during the first phase of COVID-19 [1-3].
Lands Abutting Seas, Oceans, 85% of Worlds Coronavirus Deaths
Authors: JS Craven
Published: May 2022

The Worldometer Coronavirus registered six million deaths on March 03, 2022. 85% of the deaths occurred in lands directly abutting the World Seas and Oceans. The WHO, CDC and other World Public Health Organizations suggest that humidity can aid in the fight against COVID-19 [1]. The boundary of this comment is that it is directed at indoor air quality with perspective that 40-60% humidity is positive against COVID-19. The fact that almost all the World COVID-19 deaths are in lands directly abutting the Major World Seas and Oceans, with their inherent natural humidity, does not seem to be addressed in technical literature. There seems to be a conflict. This paper provides a breakdown of the World’s deadliest coronavirus regions at the six million death milestone, compares it to the earlier evaluation by the author captured in a WordPress website [2-10], and provides an in depth breakdown of the pandemic deaths and death rates in the lands abutting the Major World Seas and Oceans. Maps are provided showing the surrounding Countries or States of Countries with death and death rate tables for each of the World’s Major bodies of water. These are startling in similarity.
Myeloid Sarcoma of the Paranasal Sinus as Solo Manifestation of Acute Myeloid Leukaemia
Authors: Carcao Andre , Goncalves Ana Isabel , Duarte Delfim , Neves Marta , Lopes Gustavo
Published: May 2022

Myeloid Sarcoma (MS) is an extramedullary manifestation of Acute Myeloid Leukemia (AML) but it can be the only manifestation of the disease [1,2]. The disease can involve any body site usually as isolated lesion and involvement of paranasal sinus is rare [2,3].
Creation of an Area Brand in the Protected Territories of Mount Etna and Alcantara River
Authors: Del Fiume Valerio Salvatore , Aloi Anna , Strano Mario , Matarazzo Agata , Zappia Emanuele Alberto , Mangano Pietro
Published: May 2022

The implementation of an efficient and effective strategy, capable of relaunching the economy of a territory and increasing its attractiveness, is now more desirable than ever. Among all possible tools, a particular European discipline has certainly found confirmation in areas with a high presence of quality productions and areas with a high sustainable value supply: the Area Brand. The aim of this paper is to increase the awareness of the readers about these approaches, related to a territory with a great development potential and a high capacity of arousing great interest even among overseas consumers and stakeholders. In particular, we considered the Sicilian territory related to Protected Areas of Messina and Catania, located in the area of "GAL Terre dell'Etna e dell'Alcantara". In this work, the brand implementation process starts with the preliminary phase, specifically with the mapping and evaluation of the production processes that may be useful and functional to a possible targeted integration of this strategy.
Simultaneous Echocardiogram and N-Terminal-Probrain Natriuretic Peptide Measurement in Neonates
Authors: Turnbough Lillie , McKenna Amber , Manzar Shabih
Published: May 2022

Natriuretic atrial peptides are secreted by the heart in response to the distension of the cardiac chambers, and the N-terminal-probrain natriuretic peptide (NT-proBNP) is used frequently by clinician as an indirect measure of cardiac distension. The direct way of getting the same information is echocardiogram which provides a structural and functional assessment of the heart in real time. This paper discusses the value of obtaining both investigations simultaneously. We examined four cases in which the data on simultaneously done NT-proBNP and echocardiogram was available. We concluded that although NT-proBNP used in conjunction with echocardiogram and clinical evaluation can be effective in monitoring neonatal cardiac hemodynamic status, but using NT-proBNP and echocardiogram at the same time is not necessary. Following clinical suspicion and initial echocardiogram, NT-proBNP can be used to trend the infant's status and guide treatment. As our sample size was small, further research using a multicenter trial would be needed to confirm our conclusions, and that could lead to the development of institutional guidelines benefiting both the hospital and patient alike.
Post-COVID Syndrome During the COVID-19 Pandemic and the Impact of COVID-19 on the Brain
Authors: Lustov Nikolay
Published: May 2022

The review provides information on the classification, mechanisms of development of infection and multiple organ damage, as well as clinical manifestations of post-COVID syndrome (Post-СOVID Conditions, Long COVID, Post-acute COVID). The issues of the impact of the new coronavirus infection COVID-19 on the human brain are also considered, its psychiatric and neurological aspects are discussed. The experience of international observations indicates a high prevalence of post-COVID symptoms.
Mushrooms as Efficient Enzymatic Machinery
Authors: Elkhateeb Waill A , EL-Ghwas Dina E , M Daba Ghoson
Published: May 2022

Mushrooms are generous source of nutritional, medicinal compounds, and industrial uses of the mushrooms still need to be worked out for their important applications. Mushrooms have significant enzymatic machinery allowing their application in different industries. Capabilities of different members of mushrooms have encouraged researchers to investigate further applications of these macrofungi in fields other than food and pharmaceutical industries. Specially, owing to the current shortage in global resources, contamination caused by plastic components and the incredible increase in population worldwide needs alternatives through macrofungi. Therefore this review aims to put light spot on enzymes production by mushrooms.
Extra Chromosomal Circular DNA: Recent Advances in Research
Authors: Khan Safir Ullah , Khan Munir Ullah
Published: May 2022

Extrachromosomal circular DNA (eccDNA) is a circular DNA molecule outside of eukaryotic staining, in which DNA forms in the genome or exogenous DNA in the cell. eccDNA is a special class of genetic material that can carry complete genes encoding functional proteins or RNA. Studies have shown that eccDNA can participate in various physiological and pathological processes in a special way, such as aging and the occurrence of tumors. This paper reviews the latest research progress of eccDNA and further expounds on the relationship between eccDNA and tumors.
Possible Correlations between the COVID-19 mRNA Vaccine and Contracting Myocarditis/Pericarditis in Young Adults
Authors: Dowling Carl
Published: May 2022

mRNA vaccines have been pivotal in the management of global health in regulating the spread and severity of COVID-19 across the world. Approximately six months post vaccine, there was concerns raised by the Food and Drug Administration (FDA) over the adverse events of inflammatory heart conditions in the younger adult demographic aged between 18-24 years old following vaccination in particular mRNA. This article will look at possible correlations between the delivery of the mRNA vaccine and the effect it has had on the younger adult population.
Environmental Sustainability Indicators Applied to Tourism Sector in Sicily
Authors: Matarazzo Agata , Antonio Zerbo , Sergio Arfo
Published: May 2022

Tourism represents one of the leading sectors worldwide and for this reason; its importance extends to a variety of studies and researches aimed to a better and more sustainable development. Tourism is an important added value to the economy of a city, of a region and therefore of a whole country. As a result, the development of this sector can be instrumental in improving the existing conditions in one place. But, it is not just an economic factor, but much more. It is not by chance that it is studied under different points of view such as economic, social, geographical and psychological. Tourism is an important source of revenue for the economy of a country because it brings money to the State which use it as a source to improve services, buildings, facilities and tourism destinations. In Italy, the tourism sector has a primary importance on the economy of the Country with an incidence on the Gross Domestic Product of 7% offering two million job positions. Every year facilities host more than 80 million people with about 350 million overnight stays. The aim of this study is to analyze environmental impact caused by tourism, thanks to the use of indicators, which varies regarding the tourism destination they are linked with. In particular, some environmental indicators on the city of Catania, in east of Sicily, are analyzed and their interaction could give a wide panorama of Sustainability in Catania and to identify all the advantages on sustainable tourism tools in Sicily.
A Review of Abdominal Dehydration (Dropsy)
Authors: Vajargah Mohammad Forouhar
Published: May 2022

Any factor that upsets the hemostatic balance of the existing body creates a condition called disease. Each group of pathogens has specific symptoms in fish, in other words, in general, the behavior and appearance of sick fish is different from healthy fish. Dropsy is one of the most ugly and difficult diseases of aquarium fish. Almost all types of aquarium fish can be infected with this disease, which unfortunately leads to the death of fish in 99% of cases. This disease is one of the easiest diseases to diagnose. But it can be said that it gives almost no response to treatment.
Revisiting and Updating Cyanorona-20: The Selective SARS-Cov-2 Inhibitor
Authors: Rabie Amgad M
Published: May 2022

Evident inhibition/blockade of the viral RNA-dependent RNA polymerase (RdRp) of the newly-emerged fatal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is considered one of the most promising and efficient approaches for developing highly potent remedies for Coronavirus Disease 2019 (COVID-19). However, almost all of the reported viral RdRp inhibitors (either repurposed or new antiviral drugs) lack specific selectivity against the novel coronaviral-2 RdRp and still at a beginning phase of advancement. In this complementary research study, the new pyrazine derivative cyanorona-20 was revisited with an update about its synthetic and toxicological data. This promising selective specific anti-COVID-19 compound is deemed to be the first distinctive derivative of favipiravir. Cyanorona-20, the unrivalled nucleoside/nucleotide analog, was designed, synthesized, characterized, computationally studied, and biologically evaluated for its anti-COVID-19/cytotoxic actions. The results of the biological assay displayed that cyanorona-20 surprisingly exhibited very high and largely significant anti-COVID-19 activities (anti-SARS-CoV-2 EC50 = 0.45 μM), and, in addition, it could be also a very promising guide and lead compound for the design and synthesis of new anti-SARS-CoV-2 and anti-COVID-19 agents through structural modifications and further computational studies. Further appraisal for the improvement of cyanorona-20 medication, through performing deeper in vivo biological evaluations and extensive clinical trials, is a prerequisite requirement in the coming days. In this short communication paper, the comprehensive chemicobiological data and information about the "Corona Antidote", cyanorona-20 compound, were briefly and collectively revisited and the synthetic and pharmacotoxicological data were updated.
Occurrence of albino seedling in Prinsepia utilis Royle
Authors: Kumar Prabal , Kumar Devendra , Singh Sanjay
Published: May 2022

Albinism in plants is characterized by partial or complete loss of chlorophyll pigments and incomplete differentiation of chloroplast membranes. This is a very common problem encountered in interspecific crosses and tissue culture experiments including anther culture and generation of doubled haploids. This impairs photosynthesis and the plants eventually die at a young stage without reaching maturity. Environmental conditions such as light, temperature, media composition and culture conditions may key factors in determining the frequency of albino plant formation. This short communication reports the first instance of albinism recorded in Prinsepia utilis Royle. An albino seedling was observed during the standardization of nursery techniques.
POTENTIAL PROBIOTIC PROPERTIES OF KOMBUCHA TEA BEVERAGE AND IT’S BENEFICIAL EFFECTS ON HUMAN HEALTH
Authors:   Department of Microbiology, Bhavans Vivekananda College, Secunderabad., Bajpai Smriti , Pandey Poonam ,   Department of Microbiology, Bhavans Vivekananda College, Secunderabad.
Published: May 2022

Fermentation is considered to be one of the most ancient methods of different food preservation techniques. During fermentation various biochemical changes take place and may affect the nutritional composition and consequently the properties of the final product, like the bioactive compounds from plants in food and beverage industries. Sugared tea fermentation with a colony of live bacteria and yeast, i.e. SCOBY (symbiotic colony of bacteria and yeast), yields fermented tea named Kombucha tea which is consumed worldwide. Kombucha tea has shown its refreshing and beneficial properties on human health. Several research findings from past decade concerning Kombucha tea have been made and reports claiming that Kombucha Tea has potential anti-microbial activity against a spectrum of organisms, can promote antioxidant activity, and improvement of the Immune system. The beneficial effects of Kombucha are attributed to the presence of bioactive compounds that act synergistically. Bacteria belong to the genus Lactobacillus sp., Acetobacter sp., Gluconobacter sp., and the Yeasts of the genus Saccharomyces, Brettanomyces are present in Kombucha. This study aimed at isolation, identification, physiological and biochemical characterization of probiotics present in Kombucha. Nevertheless, Kombucha tea could be easily recognized as a beverage which is able to replace the consumption of carbonated beverages due to its possession of health benefits and therapeutic properties. Existing reports have suggested that the protective effects of kombucha tea are as good as those of black tea, however, more studies on kombucha tea and its composition are needed before final conclusions can be made.
ANALYSIS OF THE EFFECTIVENESS OF THE USE OF ADAPTIVE TRAINING PLATFORMS IN SECONDARY VOCATIONAL EDUCATION
Authors: Zhilmagambetova R. , Mubarakov A. , Alimagambetova A.
Published: May 2022

The article considers the tasks and features of mathematics training for studentsof secondary vocational education. Special attention is paid to the need to solve the problemof adaptation of students to the conditions of study in college and the organization ofindependent work. In this regard, the authors propose to make wider use of the practiceof adaptive learning as innovative pedagogical tools. The article considers the concept ofthe effectiveness of adaptive personalized learning and suggests the directions by which itcan be evaluated. As an example, the experience of implementing an adaptive educationalcourse “Mathematics”, designed in the Articulate Storyline platform, is analyzed. The moduleis designed to organize and support adaptive learning of students of the Department ofInformation Systems by means of adaptive educational technologies. The results of thetraining are analyzed, and the possibilities of the Articulate Storyline platform in ensuringthe independent work of students are presented. The main part of the article is devotedto evaluating the effectiveness of e-learning using an adaptive educational platform. Withthe help of questionnaires and tools of the Articulate Storyline platform, an assessment ofthe educational result achieved was made, the degree of motivation of students to masterthe discipline of mathematics was analyzed, and the attitude of students to the process ofe-learning using an adaptive educational platform was investigated.
APPLICATION OF INFORMATION SYSTEMS AND TOOLS IN BIOINFORMATICS
Authors: Shevtsov V. , Ismailova A. , Aitimova U. , Khapilina O.
Published: May 2022

Abstract. The pace at which scientific data is produced and disseminated has never been ashigh as it is currently. Modern sequencing technologies make it possible to obtain the genomeof a specific organism in a few days, and the genome of a bacterial organism in less than a day,and therefore researchers from the field of life science are faced with a huge amount of datathat needs to be analyzed. In this connection, various fields of science are converging with eachother, giving rise to new disciplines. So, bioinformatics is one of these fields, it is a scientificdiscipline that has been actively developing over the past decades and uses IT tools andmethods to solve problems related to the study of biological processes. In particular, a crucialrole in the field of bioinformatics is played by the development of new algorithms, tools andthe creation of new databases, as well as the integration of extremely large amounts of data.The rapid development of bioinformatics has made it possible to conduct modern biologicalresearch. Bioinformatics can help a biologist to extract valuable information from biologicaldata by using tools to process them. Despite the fact that bioinformatics is a relatively newdiscipline, various web and computer tools already exist, most of which are freely available.This is a review article that provides an exhaustive overview of some of the tools for biologicalanalysis available to a biologist, as well as describes the key role of information systems in thisinterdisciplinary field.
GROWTH OUTCOMES OF TRANSPORT INFRASTRUCTURE INVESTMENT IN THE EU: THE ROLE OF GOVERNMENT QUALITY AND DIMINISHING MARGINAL EFFECTS
Authors: Butkus Mindaugas , Mačiulytė-Šniukienė Alma , Matuzevičiūte Kristina
Published: May 2022

The research investigates the impact of transport infrastructure investment (TII) on economic growth. We applied non-linear neoclassical specification to our unbalanced panel data that covers 27 EU countries (Cyprus is ex-cluded due to missing data and the United Kingdom is a part of the sample) for the period of 2000–2019. Our model includes a multiplicative term to evaluate if the government quality mediates the effect of TII on growth. Our research reveals the positive and statistically significant relationship between TII and economic growth but with a diminishing return. Estimation of the government quality as a possible moderator of the effect that TII has on growth shows that control of corruption plays a significant role in the TII-growth nexus. We find that in countries with a low level of con-trol of corruption, TII has a statistically significant negative effect on growth.
A Multiplanet System’s Sole Super-puff: Exploring Allowable Physical Parameters for the Cold Super-puff HIP 41378 f
Authors: Belkovski Michelle , Becker Juliette , Howe Alex , Malsky Isaac , Batygin Konstantin
Published: May 2022

The census of known exoplanets exhibits a variety of physical parameters, including densities that are measured to span the range from less dense than Styrofoam to more dense than iron. These densities represent a large diversity of interior structures. Despite this staggering diversity, recent analyses have shown that the densities of planets that orbit a common star exhibit remarkable uniformity. A fascinating exception to this is the system HIP 41378 (also known as K2-93), which contains a super-puff planet, HIP 41378 f, as well as several planets with more typical bulk densities. The range of densities in this system begs the question of what physical processes are responsible for the disparate planetary structures in this system. In this paper, we consider how the densities of the planets in the HIP 41378 system would have changed over time as the host star evolved and the planets’ atmospheres were subsequently affected by the evolving insolation level. We also present a range of allowable core masses for HIP 41378 f based on the measured planet parameters, and we comment on the feasibility of the proposed existence of planetary rings around HIP 41378 f as an explanation for its current low density.