bluuebunny/crossref_metadata_2025 huggingface dataset:
Más allá de las fronteras residenciales: un estudio de la segregación desde a movilidad cotidiana
Authors: Di Virgilio María Mercedes , Brikman Denise , Najman Mercedes
Published: May 2022

Este trabajo propone un abordaje de la segregación urbana desde la perspectiva de la movilidad cotidiana. Mediante un estudio cuantitativo con datos primarios, analiza las prácticas de movilidad por motivo de empleo y educación de habitantes de un barrio segregado de la Ciudad Autónoma de Buenos Aires, identificando su capacidad de reproducir o disminuir los efectos de la segregación residencial. Además, se exploran las diferencias micro-espaciales considerando distintos tipos de hábitat. Los resultados muestran que indistintamente del tipo de hábitat, el condicionamiento de la estructura urbana sobre los desplazamientos construye espacios de vida que reproducen las condiciones de segregación residencial.
El enfoque de paisaje como base para la política forestal. El caso de México
Authors: Serrano Flores María Elena , Heredia Telles Aide , Pérez Verdin Gustavo , Ávila Meléndez Luis Arturo
Published: May 2022

El enfoque del paisaje representa una alternativa relevante para el diseño de políticas de manejo sustentable de los recursos naturales, particularmente para el sector forestal. Con base en investigación bibliográfica y documental se revisaron las principales nociones y los alcances teóricos del concepto; como caso de referencia práctico, se describe el diseño y la operación de este enfoque en la política ambiental francesa y, finalmente, se analiza el caso mexicano. La revisión proporciona evidencia de la debilidad institucional en el diseño y la aplicación de las políticas mexicanas basadas en este enfoque.
Evaluación socioambiental del Programa Nacional Forestal en dos ejidos del municipio de Calakmul, Campeche
Authors: Hernández Dzib Germán , Martínez Romero Eduardo , Esparza-Olguin Ligia
Published: May 2022

El presente trabajo tuvo como objetivo evaluar el impacto del componente III en la modalidad B.1, (sobre Conservación y Restauración) del Programa Nacional Forestal en los ejidos Eugenio Echeverría Castellot y La Guadalupe, en el municipio de Calakmul, Campeche bajo los enfoques socioambiental y ecológico en el periodo 2010-2012. El programa evaluado no cumple con los objetivos para los que fue diseñado en los dos ejidos estudiados, ya que las condiciones socioeconómicas de la población objetivo no mejoraron y las áreas reforestadas presentaron niveles de sobrevivencia menores de 6% a tres años de su implementación. Palabras claves: política forestal, evaluación de impacto, reforestación, conservación, Calakmul.
Análisis y perspectivas sobre la pandemia de COVID-19 en Querétaro
Authors: Becerril-Tinoco Citlalli Aidee
Published: May 2022

El libro del que surge esta reseña es una aproximación científica al conocimiento de la evolución de la pandemia. Busca “entender los procesos de cambio que el SARS-CoV-2 ha provocado en distintos contextos de nuestra vida” y de la sociedad mexicana y Queretana. Las discusiones presentadas se abordan desde diferentes disciplinas científicas e incluyen una amplia variedad de temáticas. Esta obra es resultado de la colaboración de 102 autores, quienes contribuyen con la redacción de dieciocho capítulos. El libro está agrupado en cuatro categorías principales: salud, educación, entorno y sociedad. Con los resultados obtenidos de estos diálogos no solo se observan las prácticas del pasado sino la adaptación que se requiere para hacer frente a las actuales-cambiantes situaciones derivadas de una pandemia. Como científicos sociales y de ciencias duras también nos corresponde visualizar y hacer propuestas que ayuden a mejorar la vida presente y futura a partir de las experiencias y lecciones aprendidas durante la pandemia provocada por el COVID-19.
Emotion Recognition System
Authors: Anand Aditi , Srivastava Rajashvi , Banerjee Archismaan , Khare Arpit
Published: May 2022

Abstract: In today's world, the face uses expressions to convey tons of knowledge visually, hence Emotion-Recognition System can be a important focus within the space of computer-user contact. Our emotions area unit is conveyed through the stimulation of unique sets of facial muscles. They are generally refined, nevertheless advanced, signals in an expression that always contains a verdant quantity of knowledge concerning our mindset. By emotion recognition (classification), We tend to design a supervised deep-learning neural network (DNN) that offers computers the power to create speculation concerning sentiments. The most objective of our project is that we tend to apply numerous deep learning ways like convolutional neural networks to spot general human emotions
Introduction: Constructing Black Canada
Authors: Gooden Amoaba
Published: May 2022

In the spring of 2010, a call for papers on constructing blackness in Canada was issued. The intent of the call was to highlight the ways in which scholars, artists and community activists were engaging with the African diaspora in Canada. What emerged from that call was more than what I expected and is remarkably illustrative of the profound ways in which many are seeking to alter how we think about blackness in Canada.
Leveraging Railroad Land Grants and the Benefits Accruing in The New Economic Landscape
Authors: Gurney Brian , Hill Joshua P
Published: May 2022

Unlike most companies, the major railroads in the United States have proven highly resilient to the vicissi- tudes of the market. We argue that this is due neither to the unique nature of rail haulage nor to superior management acumen. Rather this solidity is due to an immense wealth transfer to the railroads in the nine- teenth century that has dramatic impacts in the present. Moreover, the government protection and encouragement that rail grants represent did not end in the nineteenth century. It continues and represents an intangible asset that, while not on railroads’ balance sheet, is very real indeed.
Clinically Relevant Enterococcus Species and PCR Screening of Antibiotic Resistance and Virulence Factor Coding Genes
Authors: Varghese Jijo G , B Anandharaj , E Fiji
Published: May 2022

Enterococci are Gram positive cocci which are common residence of gastro intestinal tracts of humans and animals. But they are capable of causing severe infections, most often in hospitalised patients. Enterococci are important nosocomial pathogens and their intrinsic property of antibiotic resistance makes treatment difficult. Against this clinical significance, a study was conducted on the prevalence of vancomycin resistant enterococcal infections and their antibiotic sensitivity patterns at Sunrise Institute of Medical Sciences, a tertiary care hospital in Kochi, Kerala state. Various clinical specimens like blood, urine, abscess, vaginal swab etc. were microbiologically screened for the presence of antibiotic resistant Enterococci. The common phenotyping methods and genotyping protocols were used to identify the species for the study. The vancomycin resistant strains were typed genotypically by using 16S rDNA sequencing and the isolates were speciated to be E. faecium. A molecular screening of the isolates was also done for the presence of various virulence factor coding genes and for the genes which confer antibiotic resistance. The findings of the study revealed that 89.1 % isolated strains were multidrug resistant and a total of 4 antibiotic resistance genes were detected. Among the isolates the vancomycin resistance genes vanA, vanB; tetracycline resistance genes tetA and macrolide resistance gene ermA were screened. The presence of genes coding for various virulence factors were also detected among the isolates. However, we present an overview of antibiotic resistance pattern and virulence factors present in enterococci and we strongly believe that these results will surely help to design a new disinfection regime and antibiotic stewardship to control the incidence of infection.
Catalytic Oxidation of 2-Amino-3-Sulfhydryl Propanoic Acid (ASPA) by 2,6- Dicarboxypyridinium Fluorochromate (DCPFC) : A Kinetic and Mechanistic Study
Authors: Mohanapriyaa S. , Dharmaraja J. , Raj V. , Kumaresand V.
Published: May 2022

2-(Pyridin-2-yl) pyridine catalyzed oxidation of 2-amino-3-sulfhydryl propanoic acid (ASPA) by 2,6- DicarboxyPyridinium Fluoro Chromate (DCPFC) has been carried out at 308 K. This amino acid oxidation leads to the formation of a product. Main objective of our present investigation is, Kinetic Oxidation reaction is carried out, from this, reaction rate law, rate equation, mechanisms and rate constant values were measured. Various factors such as Oxidant, Substrate, Acid, Solvent, Catalyst, MnSO4, Acrylonitrile, and NaClO4 influence the reaction rate. This kind of systematic kinetic work explores the physical characterization of the reacting Species. This catalyzed reaction exhibits first order dependence, with respect to [DCPFC] and fractional order with respect to [ASPA], [H+] and 2-(pyridin-2-yl)pyridine. The above reaction is carried out at methane carboxylic acid-water medium. Rate of the reaction has been influenced by varying the percentage of methane carboxylic acid. Addition of NaClO4 appreciably decreases the rate of the reaction. Addition of acrylonitrile does not influence the rate of the reactions, which rules out the polymerization reaction indicating the lack of a free radical pathway. Slight increase in the rate values occur by the addition of MnSO4, which implies that, slight catalytic behaviour of Mn2+ on Oxidation reaction. The reaction described above was carried out at four different temperatures to determine, thermodynamic parameters such as enthalpy and entropy of activation. The appropriate mechanism has been suggested based on the observed data. Our Aim is to find out the reaction mechanism pathway, Order of the reaction by means of various effects such as Oxidant effect, Solvent & Catalyst Effect, etc.,. The product analysis has been confirmed by IR spectral studies and derivative test.
1,2-Bis(4-Pyridyl) Ethane Catalysed Oxidative Conversion of D-Lactose to Lactobionic Acid by Cr(VI) in Aqueous Acetic Acid Medium: A Kinetic and Mechanistic Study
Authors: Vijaya J. , Dharmaraja J. , Raj V. , Harikrishnan B.
Published: May 2022

The kinetics of oxidation reactions and the investigations of the reaction mechanisms from the kinetic data have been always the more interesting in the chemical research and industrial applications. The kinetics of oxidation of sugars has been a subject of extensive research in recent years. The biological as well as the economic importance of carbohydrates is responsible for the great interest in the study of their bio- and physio -chemical properties. The kinetics of oxidative degradation of different sugars by metal ions including Cr (VI) has been studied under different conditions. Chomium (VI) compounds are powerful oxidants at low or neutral pH as well as Cr (VI) is a well-known oxidant in acetic media. Aim of our present investigation deals with oxidation of D-Lactose using Cr (VI) Oxidizing agent, Trimethylammonium fluorochromate [TriMAFC] which was carried out in protic solvent as a medium at 308 K in the presence of 1,2-bis(4-pyridyl)ethane as a catalyst . The oxidation of D-Lactose yields the corresponding aldonic acid and Cr3+ as final products. Lactobionic Acid (LBA) has been used for food and pharmaceutical applications. Thus the kinetics and mechanism of carbohydrates using Cr (VI) as oxidant, 1,2-bis(4-pyridyl)ethane as a catalyst is very important from biochemical and kinetic viewpoints. Our experimental studies showed that reaction progressed with first order kinetics with respect to [TriMAFC], [1,2-bis(4-pyridyl)ethane] and [H+] with the fractional Order dependence on [DLactose]. It was found that introduction of sodium perchlorate results in decrement of the reaction rate substantially. The rate constant increased with increase in the concentration of perchloric acid. Also, the rate of reaction decreases with increasing the concentration of acetic acid. For acrylonitrile, no polymerization occurs. The reaction was carried out at four different temperatures to determine the activation parameters. An appropriate mechanism was suggested based on the observed kinetic effects.
Preparation and Characterization of Advanced Nano medicine For Malaria: Box Behnken Design Approach
Authors: G. More Anuradha , R. Potbhare Parag , S. Kore Padmaja , D. Chaudhari Praveen , U. Kshirsagar Pratiksha , R. Baheti Radhika , C. Gupta Surbhi
Published: May 2022

In tropical countries, malaria is a larger cause of sickness and death in adults and children. Drug resistance with antimalarial therapy has now become a serious problem worldwide and it is the basic reason for the need of combination therapy. Artemisinin-based combination therapy (ACT) is widely used nowadays. The drugs selected for the study from ACT were an Artesunate (AST) and Lumefantrine (LUM). In this study, the optimized Solid-Self nanoemulsifying drug delivery system (S-SNEDDS) formulation of AST and LUM was developed using Box Behnken design (BBD) which showed greater in-vitro drug release when compared to marketed formulation. Both the drugs AST and LUM show high solubility in Anise oil, Tween 80 (surfactant), and PEG 400 (co-surfactant). Ternary phase diagrams were used to select nanoemulsifying regions. It was found to have a maximum nanoemulsion region with a 2:1 surfactant to co-surfactant ratio. The effect of formulation variables was studied by BBD. Thirteen formulations were prepared and were further characterized based on globule size, PDI, zeta potential, self-emulsification time, cloud point, % transmittance and in vitro dissolution profiles. The optimized Liquid-SNEDDS (L-SNEDDS) with RHLB 13.76 gives globule size (82.8 nm), % T (96.7 %), in vitro release of AST (98.4 %) and LUM (97.07%) at 45 min. was converted into S-SNEDDS by using neusilin US2 as an adsorbent. The S-SNEDDS was characterized by SEM, globule size (98.24 nm), % T (95.02 %), in vitro release of ART (95.18 %) and LUM (96.4%) at 45 min. DSC and FTIR study for S-SNEDDS assure that there was an absence of any chemical interaction within the drug and carrier. SEM, X-ray diffraction studies confirmed that drugs exist in amorphous nature. The present research successfully developed S-SNEDDS for bioavailability enhancement of AST and LUM in fix dose combination
Pharmacognostic And Phytochemical Evaluation Of Cordia Obliqua Willd Fruits
Authors: Tharun Babu G , Sivakrishnan S , Sharma Jvc
Published: May 2022

Cordia (family Boraginaceae) is a genus of deciduous flowering trees or shrubs comprising more than 300 species distributed widely in the tropical regions. The aim of this research was to provide scientific information on phramacognostical nature and presence of various phytochemicals in the fruits of Cordia obliqua. The present study helped to evaluate anatomical, histochemical, physico chemical analysis and chemical tests of various extracts of Cordia obliqua willd fruits. Common names of plants are “Naruvili, Ali and Namaviri (Tamil), Lassura Viri, Cheruvari (Kerala). China-nakeru (Andhra and Telangana)”. It is considered as one of the most important medicinal plants and various plant parts like leaves, fruits, bark and seed were found to possess abundant ethno medicinal value. Most frequently they are used to treat many ailments such as respiratory disorders, stomach pain, wound, inflammation, myalgia, cough, dysentery and diarrhoea. The fruits are widely used for the treatment of spleen and hepatic disorders. The anatomical and histochemical characteristics of the fruits of Cordia obliqua have been studied which helped in authentication and diagnose the various anatomical characters like presence of epidermis, mucilage, xylem and phloem fibers and calcium oxalate crystals. Proximate analyses of fruits were performed which included moisture content, extractive values and ash values helped to identify the purity and solubility of fruits in different solvents which was revealed by extractive values. Chemical tests helped to know the various phytoconstituents present in the fruits of Cordia obliqua when tested with various chemical reagents. Phytochemical tests revealed the presence of steroids, glycosides, alkaloids, tannins, phenolic and flavonoid compounds and carbohydrates.
Potent Anti-Diabetic Activity of Polymeric Microsphere Formulated Metformin on Streptozotocin-Induced Diabetic Rat Model
Authors: Kumar Chakra Biplab , Debnath Souvik , Mukherjee Avinaba , Kuotsu Ketousetou , Chakraborty Mayur , Kumar Chatterjee Tapan
Published: May 2022

Metformin is an extensively used drug as frontline medicine for type II diabetes. However, the target-specific delivery and efficacy of Metformin in a microsphere formulated pattern has not been studied in detail so far. Therefore, the present study is aimed to develop an oral site-specific rate-controlled anti-diabetic drug delivery system to pacify systemic side effects and offer effective and safe therapy for diabetic diseases with the compressed dose duration of treatment. To formulate this, guar gum and sodium alginate was used, whereas ethyl cellulose was applied as a coating polymer. Subsequent drug entrapment efficiency (DEE) and drug release were performed which indicates the proper formulation and sustained release of Metformin in a microsphere. Thereafter, the formulated drug was applied in Streptozotocin-induced diabetic Swiss albino rats. Histopathology of the liver, kidney, and pancreas was performed. Also, the level of liver glycogen, Glucose-6-phosphate, dehydrogenase, succinate dehydrogenase, and malate dehydrogenase content were significant (* p<0.05, **p<0.01, ***p<0.001) with the metformin-loaded microsphere treated group. Moreover, the drug release from the optimized microsphere at 12 hr was found to be 72%. The significant control in blood glucose and inclined body weight, food, and water intake showed the potential of the formulated drug. A similar range of VLDL and the other lipid profile, especially HDL level, offers the combined metformin-loaded microsphere reversal effect on cholesterol and cardiovascular risk. Overall, this study depicts, the significant antidiabetic efficacy of metformin's polymeric microsphere using natural guar gum which can improve the blood glucose level, lipid profile level, and histopathological architecture of concerned organs.

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Competencias digitales de los docentes en la Universidad de los Llanos, Colombia
Authors: Torres-Flórez Dagoberto , Rincón-Ramírez Aura Viviana , Medina-Moreno Lisset Rocío
Published: May 2022

La constante evolución de las tecnologías ha influido en los sistemas educativos en el mundo, lo que ha obligado a los profesores a desarrollar rápidamente nuevas habilidades para hacer frente a estos desafíos. El objetivo de este trabajo fue determinar el nivel de competencias digitales de los profesores de la Universidad de los Llanos (Villavicencio, Colombia) y analizar los factores que influyen en la adopción de las tecnologías de la información y la comunicación. Esta investigación utilizó una metodología que combina enfoques cuantitativos y cualitativos. Para diagnosticar las competencias docentes en saberes digitales de profesores en educación superior, se aplicó un test durante el primer semestre del año 2021 a 180 profesores de cinco facultades. Las competencias digitales se analizaron en cuatro dimensiones: (1) Información, (2) Comunicación y colaboración, (3) Uso de dispositivos y herramientas digitales y (4) Creación de contenido. Los resultados mostraron que los profesores presentan un nivel de apropiación de medio a medio-alto en todas las dimensiones, siendo la más baja la Creación de contenido. Las conclusiones destacan la importancia de implementar nuevas medidas en el entorno institucional para el fortalecimiento de competencias digitales y la adaptación a nuevas formas de enseñanza y aprendizaje.
Three-dose vaccination-induced immune responses protect against SARS-CoV-2 Omicron BA.2
Authors: Zhou Runhong , Liu Na , Li Xin , Peng Qiaoli , Yiu Cheuk-Kwan , Huang Haode , Yang Dawei , Du Zhenglong , Kwok Hau-Yee , Au Ka-Kit , Cai Jian-Piao , Hung Ivan Fan-Ngai , KW Kelvin , Xu Xiaoning , Yuen Kwok-Yung , Chen Zhiwei
Published: May 2022

Background: The ongoing outbreak of SARS-CoV-2 Omicron BA.2
infections in Hong Kong, the world model city of universal masking, has
resulted in a major public health crisis. Although the third
heterologous BNT162b2 vaccination after 2-dose CoronaVac generated
higher neutralizing antibody responses than the third homologous
CoronaVac booster, vaccine efficacy and corelates of immune protection
against the major circulating Omicron BA.2 remains to be investigated.
Methods: We investigated the vaccine efficacy against the
Omicron BA.2 breakthrough infection among 481 public servants who had
been received with SARS-CoV-2 vaccines including two-dose BNT162b2
(2×BNT, n=169), three-dose BNT162b2 (2×BNT, n=175), two-dose CoronaVac
(2×CorV, n=37), three-dose CoronaVac (3×CorV, n=68) and third-dose
BNT162b2 following 2×CorV (2×CorV+1BNT, n=32). Humoral and cellular
immune responses after three-dose vaccination were characterized and
correlated with clinical characteristics of BA.2 infection.
Results: During the BA.2 outbreak, 29.3% vaccinees were
infected. Three-dose vaccination provided protection with lower
incidence rates of breakthrough infections (2×BNT 49.2% vs 3×BNT
16.6%, p<0.0001; 2×CorV 48.6% vs 3×CoV 20.6%, p=0.003). The
third heterologous vaccination showed the lowest incidence (2×CorV+1×BNT
6.3%). Although BA.2 conferred the highest neutralization resistance
compared with variants of concern tested, the third dose
vaccination-activated spike-specific memory B and Omicron cross-reactive
T cell responses contributed to reduced frequencies of breakthrough
infection and disease severity. Conclusions: Our results have
implications to timely boost vaccination and immune responses likely
required for vaccine-mediated protection against Omicron BA.2 pandemic.
PHARMACOKINETICS OF N,N-DIMETHYLTRYPTAMINE FUMARATE IN HUMANS
Authors: Good Meghan , Benway Tiffanie , Joel Zelah , Routledge Carol , Timmermann Christopher , Erritzoe David , Weaver Richard , Allen Graham , Hughes Charlotte , Topping Helen , James Ellen
Published: May 2022

Aim: N,N-dimethyltryptamine (DMT) is a psychedelic compound under
development for the treatment of major depressive disorder (MDD). This
study evaluated the in vitro metabolism and clinical pharmacokinetics
(PK) of DMT fumarate (SPL026) in healthy subjects. Methods: Results are
from the Phase I component of an ongoing Phase I/IIa randomised,
double-blind, placebo-controlled, parallel-group, dose-escalation trial.
Healthy adults received escalating doses of SPL026 via a 2-phase
intravenous (IV) infusion. Dosing regimens were calculated based on PK
modelling and predictions, with progression to each subsequent dose
level according to safety and tolerability. In vitro experiments
assessed hepatic clearance and metabolism of DMT by monoamine oxidase
(MAO) and cytochrome P450 enzymes. Results: 24 healthy subjects received
escalating doses of SPL026 which were safe and well-tolerated.
Dose-proportional increases in DMT exposure were observed over the range
of 9–21.5 mg. For all doses, median time to peak plasma concentration
was ~10 min and mean elimination half-life was 9–12
min. There was no relationship between peak DMT plasma concentration and
body mass index, weight or age. In vitro hepatic mitochondrial fraction
clearance of SPL026 was inhibited by MAO-A, but not MAO-B, inhibition.
CYP2D6 and CYP2C19 modified SPL026 clearance in vitro. The unbound
fraction of SPL026 was approximately 70%. Conclusion: This is the first
study to determine, in detail, the full PK profile of DMT in humans,
confirming rapid attainment of peak plasma concentrations followed by
accelerated clearance. These findings provide evidence which support the
development of novel DMT infusion regimens for the treatment of MDD.
A molecular-level coupling model of fluid catalytic cracking and hydrotreating processes to improve gasoline quality
Authors: Qin Xinglong , Ye Lei , Murad Alqubati , Liu Jichang , Ying Qiang , Shen Haitao , Yu Wenxin , Xie Jinquan , Hou Lixin , Pu Xin , Han Xin , Li Jiangbing , Wang Rongjie , Liu Ning
Published: May 2022

A molecular-level Fluid Catalytic Cracking (FCC)-Gasoline Hydrotreating
(GH) process coupling model was established based on the Structure
Oriented Lumping (SOL) method to guide the precise control of the
hydrocarbon compositions in gasoline. 96 FCC reaction rules and 24 GH
reaction rules were formulated, and a reaction network containing about
120,000 reactions was constructed. In order to establish the FCC-GH
process coupling model, the effective transfer of composition
information between the two processes was realized through the molecular
composition matrix of gasoline. The molecular composition matrix of
gasoline was obtained according to the classification rules of the
molecular composition matrix of FCC products. The conversion laws of
hydrocarbon molecules in gasoline were investigated by tracking their
generation paths and reaction paths. The influences of reaction
conditions on the distribution of hydrocarbons in the product gasoline
could be calculated quantitatively by the FCC-GH process coupling model
at molecular level.
Robust method for camera self-calibration by an unkown planar scene
Authors: Baataoui A. , El Akkad N. , Masrar Med. , Saaidi A. , Satori K.
Published: May 2022

In this paper we present a self-calibration method for a CCD camera with varying intrinsic parameters based on an unknown planar scene. The advantage of our method is reducing the number of images (two images) needed to estimate the parameters of the camera used. Moreover, self-calibration equations are related to the number of points matched (very numerous and easy to detect) rather than to the number of images, since the use of a large number of images requires high computation time. On the other hand, we base on the points matched, which are numerous, when estimating the projection matrices and homographies between the images. The latter are used with the images of the absolute conic to formulate a system of non-linear equations (self-calibration equations depend on the number of matched pairs). Finally, the intrinsic parameters of the camera can be obtained by minimizing a non-linear cost function in a two-step procedure: initialization and optimization. Experiment results show the robustness of our algorithms in terms of stability and convergence.
Technique to generate face and palm vein-based fuzzy vault for multi-biometric cryptosystem
Authors: Lalithamani N. , Sabrigiriraj M.
Published: May 2022

Template security of biometric systems is a vital issue and needs critical focus. The importance lies in the fact that unlike passwords, stolen biometric templates cannot be revoked. Hence, the biometric templates cannot be stored in plain format and needs strong protection against any forgery. In this paper, we present a technique to generate face and palm vein-based fuzzy vault for multi-biometric cryptosystem. Here, initially the input images are pre-processed using various processes to make images fit for further processing. In our proposed method, the features are extracted from the processed face and palm vein images by finding out unique common points. The chaff points are added to the already extracted points to obtain the combined feature vector. The secret key points which are generated based on the user key input (by using proposed method) are added to the combined feature vector to have the fuzzy vault. For decoding, the multi-modal biometric template from palm vein and face image is constructed and is combined with the stored fuzzy vault to generate the final key. Finally, the experimentation is conducted using the palm vein and face database available in the CASIA and JAFFE database. The evaluation metrics employed are FMR (False Match Ratio) and GMR (Genuine Match Ratio). From the metric values obtained for the proposed system, we can infer that the system has performed well.
Robust method for the text line detection and splitting of overlapping text in the Latin manuscripts
Authors: Pach Jakub , Bilski Piotr
Published: May 2022

The paper presents the modified method of the text lines separation in the handwritten manuscripts. Such an approach is required for the medieval text analysis, where multiple text lines overlap and are written at different angles. The proposed approach consists in dividing the bounding boxes into smaller components based on the points of the character curves intersection. The method considers the askew text lines, producing non-rectangular zones between the neighboring lines.
Syntactic pattern recognition of ECG for diagnostic justification
Authors: Flasiński Piotr
Published: May 2022

A novel hybrid structural-parametric model for ECG diagnostic justification is presented in the paper. In order to distinguish between specific subclasses of heart dysfunction phenomena both grammars and automata are enhanced with a formalism of dynamic programming. It allows one to construct a system, which is feasible for aiding a process of teaching and evaluating medical students' diagnostic reasoning in the area of electrocardiography.
Dynamic Path Planning with Regular Triangulations
Authors: Brož Petr , Kolingerová Ivana , Szkandera Jakub , Zemek Michal
Published: May 2022

Path planning is a well known problem that has been extensively studied in many scientific disciplines. In general, it defines a task of finding a path between two given spots in an abstract environment so that the path satisfies certain criterion of optimality. Although there are many methods solving this objective, they usually assume the examined space does not change in runtime. Modern applications, however, do not have to meet these requirements, especially in case of virtual reality or computer games. Therefore, we propose a general model for real-time path planning in dynamic environment where the obstacles can nondeterministically appear, disappear, change the position, orientation or even shape. The model uses a triangulation for dynamic space subdivision among bounding spheres of the obstacles and a heuristic algorithm to repair an already found path after any change of the scene. The presented solution is the first one using regular triangulation. At the price of the suboptimal result, it provides an efficient and fast way to plan a path with the maximal clearance among the moving and changing obstacles. In comparison to raster based techniques and methods using the Delaunay triangulation (Voronoi diagram), it requires less time to preprocess and generates paths with a larger clearance.
Synthesis of novel fluorinated 1,5-benzothiazepine derivatives and their biological evaluation as anticancer and antibacterial agent
Authors: Bhabal Sonal , Shaikh Sarfaraz , Yellapurkar Ishita , Pavale Ganesh , Ramana Mucheli
Published: May 2022

A series of novel fluorinated 1,5-benzothiazepine derivatives were synthesized, characterized and evaluated for in vitro anticancer and antibacterial activity. The in vitro anticancer activity of the synthesized compounds 4a?h was evaluated against four human cancer cell lines namely lung (A549), breast (MCF-7), liver (HEPG2) and prostate (PC-3). Compounds 4c, 4d, 4g and 4h exhibited good activity with GI50 <10 ?g ml-1 against all four human cancer cell lines which was comparable to standard drug adriamycin. Additionally, antibacterial activity of synthesized compounds was estimated using Resazurin Microtiter Assay (REMA) and compared with standard drug ampicillin. Among the synthesized compounds, 4c, 4d, 4g and 4h showed good antibacterial activity and all the synthesized compounds were found to be more active towards gram negative than gram positive bacteria. These promising results obtained from in vitro anticancer and antibacterial activity, inferred that the synthesized compounds are capable of being anticancer as well as antibacterial agents.
Plasma apoM Levels and Progression to Kidney Dysfunction in Patients With Type 1 Diabetes
Authors: Baker Nathaniel L. , Hammad Samar M. , Hunt Kelly J. , Semler Andrea , Klein Richard L. , Lopes-Virella Maria F.
Published: May 2022

Apolipoprotein M (apoM), primarily carried by HDL, has been associated with several conditions, including cardiovascular disease and diabetic nephropathy. This study proposes to examine whether plasma apoM levels are associated with the development of diabetic kidney disease, assessed as progression to macroalbuminuria (MA) and chronic kidney disease (CKD). Plasma apoM was measured using an enzyme immunoassay in 386 subjects from the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) cohort at DCCT entry and closeout and the concentrations used to determine the association with risk of progression to kidney dysfunction from the time of measurement through 18 years of EDIC follow-up. apoM levels, at DCCT baseline, were higher in patients who developed CKD than in those who retained normal renal function. At DCCT closeout, participants who progressed to MA, CKD, or both MA and CKD also had significantly higher apoM levels than those who remained normal, and increased levels of apoM were associated with increased risk of progression to both MA (risk ratio [RR] 1.30 [95% CI 1.01, 1.66]) and CKD (RR 1.69 [95% CI 1.18, 2.44]). Our results strongly suggest that alterations in apoM and therefore in the composition and function of HDL in type 1 diabetes are present early in the disease process and are associated with the development of nephropathy.
Effect of Banded Roux-en-Y Gastric Bypass versus Sleeve Gastrectomy on Diabetes Remission at 5 Years Among Patients with Obesity and Type 2 Diabetes: A Blinded Randomized Clinical Trial
Authors: Murphy Rinki , Plank Lindsay D , Clarke Michael G. , Evennett Nicholas J , Tan James , Kim David DW , Cutfield Richard , Booth Michael WC
Published: May 2022

Objective: To determine whether silastic-ring laparoscopic
Roux-en-Y gastric bypass (SR-LRYGB) or laparoscopic sleeve gastrectomy (LSG) produces
superior diabetes remission at 5 years.

Research
Design and Methods: In a single-centre
double-blind trial, 114 adults with type 2 diabetes and BMI 35-65kg/m2 were randomized to SR-LRYGB or LSG
(1:1; stratified by age group, BMI group, ethnicity, diabetes duration and
insulin therapy) using a web-based service. Diabetes and other metabolic
medications were adjusted according to a prespecified protocol. The primary
outcome was diabetes remission assessed at 5 years, defined by HbA1c <6% (42mmol/mol)
without glucose-lowering medications. Secondary outcomes included changes in
weight, cardiometabolic risk factors, quality of life, and adverse events.

Results: Diabetes remission after SR-LRYGB vs LSG occurred
in 25/53 (47%) vs 18/55 (33%), adjusted odds ratio 4.5; 95% CI 1.6, 15.5; P=0.009;
and 4.2; 95% CI 1.3, 13.4; P=0.015 in the intention-to-treat analysis. Percentage
body weight loss was greater after SR-LRYGB than after LSG (absolute
difference, 10.7%; 95% CI 7.3, 14.0; P<0.001). Improvements in
cardiometabolic risk factors were similar, but high-density lipoprotein
cholesterol increased more after SR-LRYGB. Early and late complications were
similar in both groups. General health and physical functioning improved after
both types of surgery, with greater improvement in physical functioning after SR-LRYGB.
People of Māori or Pacific ethnicity (26%) had lower incidence of diabetes
remission than those of European or other ethnicities (2/25 vs 41/83,
P<0.001).

Conclusions:
SR-LRYGB provided superior diabetes
remission and weight loss compared to LSG at 5 years, with similarly low risk
of complications.
Laser Gaussian beam analysis of structure constant depends on Kolmogorov in turbulent atmosphere for a variable angle of wave propagation
Authors: Khamees Hussein Thary
Published: May 2022

Laser Gaussian beam propagation is important in optical communications; the challenges of the measured constant parameters are varied angle wave propagation, the receiver plan in the slant path of laser Gaussian beam (G) in Kolmogorov gauges, and the effect of the laser in a random medium. At this point, atmospheric turbulence is reputable based on laser Gaussian beam propagation. Moreover, the space propagation of Gaussian beam waves of higher-order Gaussian beam modes has been expanded from the effects of the scintillation index and with different zenith angles between the laser propagator and the detector (receiver) in the ramp path. Furthermore, in the Cartesian coordinate system, the scintillation index in the Kolmogorov standard is evaluated, and it employs two methods; first, Huygens–Fresnel fundamental and, second, random phase screen for work synchronization. Additionally, to analyze the contour parameters of constant construction, the intensity and receiver field is found to compute the high turbulent modes in the atmospheric deposition, which depends on propagation distances. These result in significant reserves in the matlab computation period and serve the imitation for enhancement of the link transmission; therefore, the zenith angle and scintillation index are pretentious by slant beam, and they enhance the performance that makes the comparisons found with fixed structure constant parameters C2n and the propagation distance against the scintillation index.
Assessment of Heavy Metal Pollution of Surface Soils from Scrapyards in Benin City, Nigeria
Authors: AF Eghomwanre
Published: May 2022

Scrap metals found in scrapyards accounts for a large proportion of municipal solid waste in Nigeria. They are a menace to the environment and pose potential health risk to nearby residents. T his study assessed the physicochemical quality and heavy meta l contamination of surface soils from selected scrapyards in Benin City, Nigeria. Surface soils were collected from 12 randomly selected scrapyards between February and April 2018. Physicochemical analyses were carried out using standard analytical methods , while heavy metal ( Fe, Cd, Zn, Cr, and Pb ) concentrations were determined using atomic absorption spectrophotometry. The physicochemical indicators showed values which ranged from 6.17 ± 1.17 to 7.81 ± 0.88, 335.00 ± 60.62 to 2467.33 ± 1708.95μS/cm and 2 .18 ± 0.39 to 44.27 ± 17.72 mg/kg for pH, electrical conductivity (EC) and nitrate ( NO - 3 ) respectively. The texture of the scrapyard soils was predominantly sand. The concentrations of the heavy metals in the scrapyard sites were significantly ( p < 0.05 ) higher than the control site. A strong positive correlation existed among the studied metals. The concentrations of heavy metals were above the WHO/FAO critical level of 100 mg/kg except for Cr and Cd. Contamination indexes of the scrapyard soils showed th at the soils samples from all the locations were highly contaminated with heavy metals. There is urgent need for evacuation of the scrap metal wastes from the scrapyards and enactment of appropriate legislations which prohibits the use of land in residenti al areas as scrapyards in the city to prevent likely health hazard
Moss, Lichens and Phytobenthos Bioindicators of Pollution
Authors: Guerrieri Nicoletta
Published: May 2022

The use of lichens, mosses and phytobenthos as biomonitors of air and water pollution by heavy metals is discussed on the basis of the literature and the author’s own experience. The usefulness of the available monitoring techniques is critically evaluated. Moss and lichens are considered very useful biodindicators especially for large-scale studies of heavy-metal deposition from the atmosphere. National and international organization standardized and shared monitoring protocols. We analysed the recent literature from 2019 to April 2020 and selected some significant case studies that contribute to an improvement of the analytical methods and to a development of new tools. A wide literature reports monitoring of air pollution with moss and lichens, both natural and transplanted. The use of transplanted moss as bioindicator of water pollution is less represented in the available literature. Phytobenthos represents a new frontier in the aquatic ecosystem monitoring and even if a standardized method has not yet been finalized, it represents a potential very useful biomonitor of metals, emergent pollutants and also microplastics in aquatic environment. New tools, new technologies are emerging from recent literature and the relationship between environment and human health starts to be studied from a different point of view.
News Making, COVID 19 Pandemic: A Radical Analysis on Risk on Waste Management
Authors: Federici Raffaele
Published: May 2022

The COVID 19 outbreak has triggered a global emergency. The corona virus crisis has led to a radical change in the space-time of everyday life. Workplaces and public spaces have been closed. The physical and social differentiation of the spaces of everyday life collapsed. Words such as lockdown, corona virus, personal protective equipment, isolation, physical distancing, spill over, zero patients, positive patient, intensive care, suppression, attenuation, have entered into the common language by configuring the language in a almost warlike terms. The logic of language always has some evidence and, in the current pandemic, the defence of human health seems to become a detailed conflict on the invasion of the virus, and in this specific semantic basin, every nuance seems to lose its meaning and everything becomes radical. In emergency times, waste management becomes, or rather, returns to be a serious and complex problem.
Xenobiotics: The Impact of SARS-CoV-2 on the Evolutionary Development of Human
Authors: A Vladyko
Published: May 2022

The importance and role of xenobiotics involved in the development of the microbiota is a determining factor in the evolutionary development of mammals, the entire animal and plant world. This is confirmed by the emergence of new and emerging infectious agents. The gut microbiome (normal microflora) plays a decisive role in maintaining normal physiological "immune and hormonal" processes in the human body and is an "ambulance" or a kind of "adaptogen" that restores the natural course of positive evolution of living organisms when exposed to adverse environmental factors. Biological, chemical, physical and other factors adversely affecting the microbiome can lead to numerous medical problems, including the appearance of multiple endo- and exogenous infectious pathogens (bacterial, viral, parasitic, fungal diseases), as well as somatic diseases such as obesity, diabetes, autoimmune and oncological diseases, as well as disorders of the central nervous system. This report attempts to open up the natural mechanisms involved in the formation of new types of pathogens, including SARS-CoV-2, in order to use biological laws for medical purposes. Currently, the opposite happens, eliminating medical problems, a person negatively affects the process of his improvement, turning Homo Sapiens into Homo Degradatum, while including the whole plant and animal world in this negative process.
Influence of Bioaugmentation on the Decontamination of Heavy Metal Impacted Landfill Soil
Authors: Pariatamby Agamuthu
Published: May 2022

The research is aimed to decontaminate heavy metal polluted landfill soil using consortia of fungi as bioaugmentation agents. Two consortia namely highly metal tolerant fungi (HMTF) and moderately metal tolerant fungi (MMTF) were used for the bioaugmentation. The experiment was conducted at day 0, 20, 60, and 100. Soil physicochemical parameters (pH, conductivity, redox potentials, and metal concentrations) were found to decline along the duration of the experiment. The maximum metal removal (48%) was achieved in soil treated with HMTF. Both treatments were efficient than the control (P < 0.05). The bioremediation efficiency was significantly influenced by the bioaugmented fungi. Therefore, the technique can be utilized for future treatment of metal impacted soil.
Promovendo o bem-estar vocal do professor
Authors: Ferreira Léslie Piccolotto , Rocha Raiza Brasileiro , Centurion Daniella Spacassassi , De Souza Thelma Mello Thomé , Giannini Susana Pimentel Pinto
Published: May 2022

Introdução: apesar das questões relacionadas à voz do professor serem muito pesquisadas, poucas iniciativas de intervenção na modalidade remota têm sido analisadas. Objetivo: avaliar o conhecimento de informações referentes ao autocuidado sobre a voz, na perspectiva de professores, que concluíram o curso “Promovendo o Bem-Estar Vocal do Professor” realizado pela Escola Municipal de Saúde de São Paulo, na modalidade on-line. Método: pesquisa, de natureza observacional e transversal, analisou as respostas de 162 participantes dadas a um questionário apresentado no início e ao final de um curso que contou com oito módulos e três encontros presenciais (total 40 horas). Por meio de análise estatística foi comparado o conhecimento de informações e práticas de autocuidado com a voz. Resultados: diferença estatisticamente significativa foi registrada ao final do curso, com relato de maior conhecimento sobre os cuidados para manter a voz saudável; como a voz é produzida; uso de recursos de expressividade verbal e não verbal; observação da interferência das emoções na voz e pensar em estratégias para melhorar o ambiente de trabalho. Os exercícios de aquecimento e desaquecimento vocal e os de ressonância foram praticados por um número de sujeitos aquém do esperado. Conclusão: os professores que participaram do curso “Promovendo o Bem-Estar Vocal do Professor”, em sua maioria, foram sensibilizados, com registro de maior conhecimento sobre a produção da voz e autocuidado. Alguns ajustes devem ser feitos na oferta deste curso a próximas turmas, quanto à realização e incorporação no dia a dia das práticas apresentadas.
uso da voz nos rituais indígenas Pankararu
Authors: Carvalho Andressa Thaiany , Vaz Masson Maria Lúcia
Published: May 2022

Introdução: a voz é essencial para preservação e manutenção da cultura de grupos sociais. O povo Pankararu, vincula sua língua-mãe aos rituais religiosos. A principal forma de transmitir a tradição oral é através dos cantos nos rituais dos Praiás. Objetivo: resgatar o uso de voz pelos cantadores Pankararu no ritual dos Praiás, à luz do saber tradicional e científico. Método: estudo qualitativo, do tipo história de vida, autobiográfica, no qual foram acessadas memórias individuais e coletivas da comunidade Pankararu, considerando a caracterização do povo, do ambiente e o uso de voz nos rituais. Resultados: os cantadores utilizam a voz de maneira intensa e contínua, sem hidratação, e fumam cachimbo durante o ritual. O local onde cantam é um terreiro, espaço aberto, exposto às intempéries da natureza, com presença de poeira. Para cuidar da voz, baseiam-se no saber tradicional, apresentando uma visão distinta do conhecimento científico, no qual a voz representa sua cultura e identidade. Nesta perspectiva, hábitos descritos pela literatura como deletérios, são considerados saudáveis, demonstrando uma concepção singular de saúde. Conclusão: o conhecimento científico, paralelamente ao tradicional, poderá contribuir para estabelecimento de cuidados que visem à saúde vocal dos Pankararus.  Poderei oferecer ao meu povo, o qual apresenta demandas de saúde, conhecimentos científicos proporcionando uma melhor qualidade de voz e vida.