bluuebunny/crossref_metadata_2025 huggingface dataset:
HOCA TAHSİN EFENDİ’NİN HEY’ET İLMİ ÜZERİNE BİR MANZUMESİ
Authors: ALGÜL Mesut
Published: April 2019

Divan şiiri,
insana dair her ayrıntıyı ihtiva eden çok zengin bir şiir geleneğidir. Bu
gelenek ilimden beslenir. Divan şairleri, aynı zamanda birer âlim ve muhtelif
mesleklere sahip kişilerdir. Divan şiiri ve ilim arasındaki ilişki birbirini
tamamlamak seviyesini geçerek ayniyet derecesi de gösterebilir. Öyle ki Osmanlıda
hemen her âlim bir tarafıyla şair, her şair de bir ölçüde âlimdir. Bu yönüyle
bakıldığında, kaleme alınan her bir edebî eserde ilmî unsurlarla karşılaşmak;
her bir ilmî eserde de edebî ürünlere rastlamak mümkündür. Şairler, sahip
oldukları birikimi edebî eserlerine özellikle de divanlarına büyük bir
titizlikle nakşetmişlerdir. Bununla birlikte, yazdıkları ilmî eserlerde de pek
çok manzum parçalara yer vermişlerdir. Şiirlerdeki bu ilmî birikimi ve ilmî
eserlerdeki manzum parçaları tespit etmek, divan şiirinin anlam dünyasının
zenginliğini gösterme açısından önemlidir. 

Hoca
Tahsin Efendi, Osmanlı’nın son dönemlerinde yaşamış önemli fikir
adamlarındandır. Çeşitli bilim dallarında yazılmış pek çok eseri bulunmaktadır.
Bu eserlerin bir kısmında onun şairlik yönünü ortaya koyan manzumeler
bulunmaktadır. Esâs-ı İlm-i Hey’et de
bu eserlerden birisidir. Hoca Tahsin Efendi, bu eserinde yer alan kaside nazım
şekliyle yazılmış manzumesinde o dönemin astronomi bilgisini edebî bir üslupla
anlatmaya çalışmıştır. Çalışma kapsamında, astronomi ile ilgili bu manzume ilmî
ve edebî boyutlarıyla ele alınacaktır.
KLÂSİK TÜRK ŞİİRİNDE “DAİRE ÇEKMEK/ÇİZMEK” DEYİMİNİN KÜLTÜREL KÖKENLERİNE DAİR
Authors: YILMAZ Hanım
Published: April 2019

Klâsik
Türk şiirindeki bazı söyleyişlerde ve deyimlerde çeşitli inançlara dair izler
görülmektedir. Bu inançların tarihsel sürecine bakıldığında oldukça geriye
gittiği takip edilebilir. Eski medeniyetlerde izlerine rastlanılan  ifadeler Jung’un “toplumsal bilinçdışı” ifadesiyle farklı kültürlerde ve çeşitli
sanat dallarında yerini almıştır. Bu çalışmada ise klâsik Türk şiirinde geçen “daire çekmek/çizmek” deyiminin kökenleri
ve kullanımı değerlendirilecektir.
A Characterization of Factorable Surfaces in Euclidean 4-Space E^4
Authors: Büyükkütük Sezgin , Öztürk Günay
Published: April 2019

In this
paper, we consider a factorable surface in Euclidean E^4 with its curvature
ellipse. We classify the origin of the normal space of such a surface according
to whether it is hyperbolic, parabolic, or elliptic. Further, we give the
necessary and sufficient condition of the factorable surface to become Wintgen
ideal surface.
Microstructural and Thermal Characterization of Aluminum Bronzes
Authors: Doğan Z. Ezel , Kahrıman Fulya , Atapek Ş. Hakan
Published: April 2019

In this
study, microstructures and the solidification characteristics of heat treatable
Cu-Al-Fe-Ni based alloys were investigated. Initial microstructural features of
conventional alloys were examined by microscopical analyzes and not only
martensitic structure but also several kappa phases embedded in copper based
matrix were observed. Then, thermal analyzes were performed in order to reveal
out the solidification sequence under cooling and the findings on the
crystallization were in good agreement with the data reported
earlier.
Antimicrobial Properties of Silk Fabrics Dyed with Green Walnut Shell (Juglans regia L.)
Authors: UZKUL Hülya , ALKAN Rezan
Published: April 2019

Natural dyes are obtained from plants, insects,
lichens, fungus and molluscs which have been used since ancient times. These
dyes have antimicrobial, anticarcinogenic and antihelmintic properties. Walnut
(Juglans regia L.), a species of Juglandaceae
family, is grown in Turkey. Green walnut shell has also antimicrobial functions
due to its juglone components known as one of the strongest antimicrobial
chemical compound. In this study, alum-mordanted and unmordanted silk fabrics
were dyed with green walnut shell. Concentration was varied at 50, 100, 150 and
200 % owf (weight of fabric), in order to assess antimicrobial properties of
green walnut shell. Pathogenic strains of Staphylococcus
aureus subsp.  aureus (ATCC 29213) and Escherichia
coli (ATCC 25922) were used to test for fabrics’ antimicrobial activities.
Reductions of bacterial growth were determined using AATCC test methods. All
the fabrics which were dyed with green walnut shell indicated antimicrobial
effect on both bacteria species. Antimicrobial effect was increased from 50 to
200 % owf (weight of fabric) dye concentration. These results indicated that
unmordanted silk fabrics dyed with green walnut shell had antimicrobial effect
as high as alum-mordanted silk fabrics dyed with green walnut shell and S.aureus were more sensitive than E.coli.
Placement of Products and Improvement of Order Picking Process through Association Analysis: A Case Study in Pharmaceutical Warehouse
Authors: DİNÇER Fatma , FIĞLALI Alpaslan
Published: April 2019

While taking strategic decisions for the future
in today's business world, which has a constantly changing and dynamic
structure, several implications can be drawn with the information obtained from
databases and the correct processing and analysis of this information. With
regard to these implications, various decisions can be taken to improve the
processes. Businesses can execute their processes more efficiently and they are
able to make better decisions on the future by processing the data that will benefit
by using the data mining techniques. In this study, the past orders of a
pharmaceutical company were analyzed and an association analysis of the
products in these orders was performed and a methodological framework has been
presented based on the Apriori Algorithm results to ensure that the products
are placed at the optimum level in the warehouse. Therefore, this study
contributes to the improvement of order picking process.
Capillary force-induced superlattice variation atop a nanometer-wide graphene flake and its moiré origin studied by STM
Authors: Thomas Loji K , Reichling Michael
Published: April 2019

We present strong experimental evidence for the moiré origin of superlattices on graphite by imaging a live transition from one superlattice to another with concurrent and direct measurement of the orientation angle before and after rotation using scanning tunneling microscopy (STM). This has been possible due to a fortuitous observation of a superlattice on a nanometer-sized graphene flake wherein we have induced a further rotation of the flake utilizing the capillary forces at play at a solid–liquid interface using STM tip motion. We propose a more “realistic” tip–surface meniscus relevant to STM at solid–liquid interfaces and show that the capillary force is sufficient to account for the total expenditure of energy involved in the process.
On the Mass Accretion Rate and Infrared Excess in Herbig Ae/Be Stars
Authors: Arun R. , Mathew Blesson , Manoj P. , Ujjwal K. , Kartha Sreeja S. , Viswanath Gayathri , Narang Mayank , Paul K. T.
Published: April 2019

The present study makes use of the unprecedented capability of the Gaia mission to obtain the stellar parameters such as distance, age, and mass of HAeBe stars. The accuracy of Gaia DR2 astrometry is demonstrated from the comparison of the Gaia DR2 distances of 131 HAeBe stars with the previously estimated values from the literature. This is one of the initial studies to estimate the age and mass of a confirmed sample of HAeBe stars using both the photometry and distance from the Gaia mission. Mass accretion rates are calculated from Hα line flux measurements of 106 HAeBe stars. Since we used distances and the stellar masses derived from the Gaia DR2 data in the calculation of the mass accretion rate, our estimates are more accurate than previous studies. The mass accretion rate is found to decay exponentially with age, from which we estimated a disk dissipation timescale of 1.9 ± 0.1 Myr. The mass accretion rate and stellar mass exhibit a power-law relation of the form

. From the distinct distribution in the values of the infrared spectral index,

, we suggest the possibility of difference in the disk structure between Herbig Be and Herbig Ae stars.
Hubble Ultraviolet Spectroscopy of Jupiter Trojans
Authors: Wong Ian , Brown Michael E. , Blacksberg Jordana , Ehlmann Bethany L. , Mahjoub Ahmed
Published: April 2019

We present the first ultraviolet spectra of Jupiter Trojans. These observations were carried out using the Space Telescope Imaging Spectrograph on the Hubble Space Telescope and cover the wavelength range 200–550 nm at low resolution. The targets include objects from both of the Trojan color subpopulations (less-red and red). We do not observe any discernible absorption features in these spectra. Comparisons of the averaged UV spectra of less-red and red targets show that the subpopulations are spectrally distinct in the UV. Less-red objects display a steep UV slope and a rollover at around 450 nm to a shallower visible slope, whereas red objects show the opposite trend. Laboratory spectra of irradiated ices with and without H2S exhibit distinct UV absorption features; consequently, the featureless spectra observed here suggest H2S alone is not responsible for the observed color bimodality of Trojans, as has been previously hypothesized. We propose some possible explanations for the observed UV-visible spectra, including complex organics, space weathering of iron-bearing silicates, and masked features due to previous cometary activity.
The Resolved Distributions of Dust Mass and Temperature in Local Group Galaxies
Authors: Utomo Dyas , Chiang I-Da , Leroy Adam K. , Sandstrom Karin M. , Chastenet Jérémy
Published: April 2019

We utilize archival far-infrared maps from the Herschel Space Observatory in four Local Group galaxies (Small and Large Magellanic Clouds (SMC and LMC), M31, and M33). We model their spectral energy distribution from 100 to 500 μm using a single-temperature modified blackbody emission with a fixed emissivity index of β = 1.8. From the best-fit model, we derive the dust temperature,

, and the dust mass surface density,

, at 13 pc resolution for SMC and LMC, and at 167 pc resolution for all targets. This measurement allows us to build the distribution of dust mass and luminosity as functions of dust temperature and mass surface density. We compare those distribution functions among galaxies and between regions in a galaxy. We find that LMC has the highest mass-weighted average

, while M31 and M33 have the lowest mass-weighted average

. Within a galaxy, star-forming regions have higher

and

relative to the overall distribution function, because of more intense heating by young stars and higher gas mass surface density. When we degrade the resolutions to mimic distant galaxies, the mass-weighted mean temperature gets warmer as the resolution gets coarser, meaning that the temperatures derived from unresolved observations are systematically higher than those in highly resolved observations. As an implication, the total dust mass is lower (underestimated) in coarser resolutions. This resolution-dependent effect is more prominent in clumpy star-forming galaxies (SMC, LMC, and M33) and less prominent in a more quiescent massive spiral (M31).
Detecting the Sagittarius Stream with LAMOST DR4 M Giants and Gaia DR2
Authors: Li Jing ,   (LAMOST FELLOW), Liu Chao , Xue Xiangxiang , Zhong Jing , Weiss Jake , Carlin Jeffrey L. , Tian Hao ,   (LAMOST FELLOW)
Published: April 2019

We use LAMOST DR4 M giants combined with Gaia DR2 proper motions and ALLWISE photometry to obtain an extremely pure sample of Sagittarius (Sgr) stream stars. Using TiO5 and CaH spectral indices as indicators, we selected a large sample of M-giant stars from M-dwarf stars in LAMOST DR4 spectra. Considering the position, distance, proper motion, and angular momentum distribution, we obtained 164 pure Sgr stream stars. We find that the trailing arm has higher energy than the leading arm in the same angular momentum. The trailing arm we detected extends to a heliocentric distance of ∼130 kpc at

Λ

˜

⊙

∼
170
°

, which is consistent with the feature found in RR Lyrae in Sesar et al. Both of these detections of Sgr, in M-giants and in RR Lyrae, imply that the Sgr stream may contain multiple stellar populations with a broad metallicity range.
Magnetically Induced Current Piston for Generating Extreme-ultraviolet Fronts in the Solar Corona
Authors: Wongwaitayakornkul Pakorn , Haw Magnus A. , Li Hui , Bellan Paul M.
Published: April 2019

Single-pulse, globally propagating coronal fronts, called Extreme-ultraviolet (EUV) waves, were first observed in 1995 by the Extreme-ultraviolet Imaging Telescope and every observed EUV wave since has been associated with a coronal mass ejection (CME). The physical mechanism underlying these waves has been debated for two decades with wave or pseudo-wave theories being advocated. We propose a hybrid model where EUV waves are compressional fronts driven by a reverse electric current layer induced by the time-dependent CME core current. The reverse current layer flows in a direction opposite to the CME core current and is an eddy current layer necessary to maintain magnetic flux conservation above the layer. Repelled by the core current, the reverse current layer accelerates upward so it acts as a piston that drives a compressional perturbation in the coronal regions above. Given a sufficiently fast piston speed, the compressional perturbation becomes a shock that separates from the piston when the piston slows down. Since the model relates the motion of the EUV front to CME properties, the model provides a bound for the core current of an erupting CME. The model is supported and motivated by detailed results from both laboratory experiments and ideal 3D magnetohydrodynamic simulations. Overlaps and differences with other models and spacecraft observations are discussed.
Constraints on the Spacetime Metric around Seven “Bare” AGNs Using X-Ray Reflection Spectroscopy
Authors: Tripathi Ashutosh , Yan Jinli , Yang Yuchan , Yan Yunfeng , Garnham Marcus , Yao Yu , Li Songcheng , Ding Ziyu , Abdikamalov Askar B. , Ayzenberg Dimitry , Bambi Cosimo , Dauser Thomas , García Javier A. , Jiang Jiachen , Nampalliwar Sourabh
Published: April 2019

We present the study of a sample of seven “bare” active galactic nuclei observed with Suzaku. We interpret the spectrum of these sources with a relativistic reflection component and we employ our model relxill_nk to test the Kerr nature of their supermassive black holes. We constrain the Johannsen deformation parameters α
13 and α
22, in which the Kerr metric is recovered when α
13 = α
22 = 0. All our measurements are consistent with the hypothesis that the spacetime geometry around these supermassive objects is described by the Kerr solution. For some sources, we obtain quite strong constraints on α
13 and α
22 when compared to those found in our previous studies. We discuss the systematic uncertainties in our tests and the implications of our results.
Magnetic Field Rearrangement in the Photosphere Driven by an M5.0 Solar Flare
Authors: Xu Zhe , Yang Jiayan , Ji Kaifan , Bi Yi , Yang Bo
Published: April 2019

Sunspot structures can be significantly affected by major flares. In this study, we reported a large penumbral area experiencing two kinds of transformations during the flare SOL2013-11-03T05:22 (M5.0). One penumbral segment decayed and transformed into a small pore when swept by the flare ribbon. At the same time, an adjacent penumbral segment expanded, permeating the granular area along the flaring magnetic polarity inversion line. EUV and X-ray observations indicated that the penumbral enhancement area was close to the flare center, while the penumbral decay area was on the relatively outer side. By tracking the magnetic motions and local magnetic field changes, we found that the magnetic transformations within two regions were totally different during the flare. The central penumbral enhancement area was accompanied by the field collapsing down, whereas the outer penumbral decay area was associated with the field lifting up toward the upper flare center. Particularly, following the uplift motion of the magnetic fields in the outer region, the magnetic flux in the decaying penumbra decreased and that in the forming pore subsequently increased. These results implied that the rearrangement of the magnetic field during the flare would be the action that resulted in the variations of sunspot structures.
RELICS: High-resolution Constraints on the Inner Mass Distribution of the z = 0.83 Merging Cluster RXJ0152.7-1357 from Strong Lensing
Authors: Acebron Ana , Alon May , Zitrin Adi , Mahler Guillaume , Coe Dan , Sharon Keren , Cibirka Nathália , Bradač Maruša , Trenti Michele , Umetsu Keiichi , Andrade-Santos Felipe , Avila Roberto J. , Bradley Larry , Carrasco Daniela , Cerny Catherine , Czakon Nicole G. , Dawson William A. , Frye Brenda , Hoag Austin T. , Huang Kuang-Han , Johnson Traci L. , Jones Christine , Kikuchihara Shotaro , Lam Daniel , Livermore Rachael C. , Lovisari Lorenzo , Mainali Ramesh , Oesch Pascal A. , Ogaz Sara , Ouchi Masami , Past Matthew , Paterno-Mahler Rachel , Peterson Avery , Ryan Russell E. , Salmon Brett , Sendra-Server Irene , Stark Daniel P. , Strait Victoria , Toft Sune , Vulcani Benedetta
Published: April 2019

Strong gravitational lensing (SL) is a powerful means of mapping the distribution of dark matter. In this work, we perform an SL analysis of the prominent X-ray cluster RXJ0152.7-1357 (z = 0.83, also known as CL0152.7-1357) in Hubble Space Telescope images, taken in the framework of the Reionization Lensing Cluster Survey (RELICS). On top of a previously known z = 3.93 galaxy multiply imaged by RXJ0152.7-1357, for which we identify an additional multiple image, guided by a light-traces-mass approach, we identify seven new sets of multiply imaged background sources lensed by this cluster, spanning the redshift range [1.79–3.93]. A total of 25 multiple images are seen over a small area of ∼0.4 arcmin2, allowing us to put relatively high-resolution constraints on the inner matter distribution. Although modestly massive, the high degree of substructure, together with its very elongated shape, makes RXJ0152.7-1357 a very efficient lens for its size. This cluster also comprises the third-largest sample of z ∼ 6–7 candidates in the RELICS survey. Finally, we present a comparison of our resulting mass distribution and magnification estimates with those from a Lenstool model. These models are made publicly available through the Mikulski Archive for Space Telescopes.
Multiepoch Ultraviolet HST Observations of Accreting Low-mass Stars
Authors: Robinson Connor E. , Espaillat Catherine C.
Published: April 2019

Variability is a defining characteristic of young low-mass stars that are still accreting material from their primordial protoplanetary disk. Here we present the largest Hubble Space Telescope (HST) variability study of classical T Tauri stars (CTTS) to date. For five of these objects, we obtained a total of 25 spectra with the Space Telescope Imaging Spectrograph. Mass accretion rates and the fraction of the star covered by accretion columns (i.e., filling factors) were inferred using 1D NLTE physical models whose parameters were fit within a Bayesian framework. On week-long timescales, typical changes in the mass accretion rates range up to a factor of about two, while changes of up to a factor of about five are inferred for the filling factors. In addition to this, we observed a possible accretion burst in the transitional disk system GM Aur, and an incident we interpret as a chance alignment of an accretion column and the undisturbed photosphere along our line of sight in the full disk system VW Cha. We also measure correlations between mass accretion rate and line luminosities for use as secondary tracers of accretion. We place our objects in context with recent high-cadence photometric surveys of low-mass star formation regions and highlight the need for more broad-wavelength, contemporaneous data to better understand the physical mechanisms behind accretion variability in CTTS.
Asymptotically Stable Numerical Method for Multispecies Momentum Transfer: Gas and Multifluid Dust Test Suite and Implementation in FARGO3D
Authors: Benítez-Llambay Pablo , Krapp Leonardo , Pessah Martin E.
Published: April 2019

We present an asymptotically and unconditionally stable numerical method to account for the momentum transfer between multiple species. Momentum is conserved to machine precision. This implies that the asymptotic equilibrium corresponds to the velocity of the center of mass. Aimed at studying dust dynamics, we implement this numerical method in the publicly available code FARGO3D. To validate our implementation, we develop a test suite for an arbitrary number of species, based on analytical or exact solutions of problems related to perfect damping, damped sound waves, shocks, local and global gas–dust radial drift in a disk, and linear streaming instability. In particular, we obtain first-order steady-state solutions for the radial drift of multiple dust species in protoplanetary disks (PPDs), in which the pressure gradient is not necessarily small. We additionally present nonlinear shearing-box simulations of the streaming instability and compare them with previous results obtained with Lagrangian particles. We successfully validate our implementation by recovering the solutions from the test suite to second- and first-order accuracy in space and time, respectively. From this, we conclude that our scheme is suitable, and very robust, to study the self-consistent dynamics of several fluids. In particular, it can be used for solving the collisions between gas and dust in PPDs, with any degree of coupling.
Possible Detection of Torsional Alfvén Waves within an Interplanetary Magnetic Cloud
Authors: Guo Jianpeng , Wang Zehao , Feng Xueshang , Li Bo , Shi Mijie , Huang Hui , Lin Haibo , Yang Lei , Liu Chaoxu , Zhong Jiayong , Wei Yong , Yan Yihua , Wan Weixing
Published: April 2019

Although it is believed that Alfvén waves can be present in the form of torsional modes in interplanetary magnetic flux ropes, convincing observational evidence remains elusive. In this Letter, we report the detection of Alfvén waves embedded within an interplanetary magnetic cloud (MC) on 2003 March 20, which exhibited features quite different from those upstream and downstream. The magnetic field inside the MC underwent alternate rotations along an arc through a relatively small angle in the plane perpendicular to the minimum variance direction, which seems consistent with the appearance of torsional modes. A significant poloidal motion of plasma existed in the MC, thus it is possible that the field-aligned helical plasma flow was mixed with Alfvén waves exhibiting high correlation between plasma velocity and the magnetic field.
A new species of the millipede genus Cryptocorypha Attems, 1907, from northern Thailand (Polydesmida, Pyrgodesmidae)
Authors: Likhitrakarn Natdanai , Golovatch Sergei I. , Srisonchai Ruttapon , Sutcharit Chirasak , Panha Somsak
Published: April 2019

The millipede family Pyrgodesmidae and the genusCryptocoryphaare recorded from Thailand for the first time, being represented there byC.enghoffisp. n.The new species is distinguished by the evident apicodorsal trichostele on the last tibia of both sexes and the gonopodal telopodite being particularly complex, quadripartite, consisting of the longest, mesal, suberect solenomere branch; a slightly shorter, similarly slender, acuminate endomere branch tightly appressed to the solenomere; a somewhat shorter, caudal, strongly curved, armed exomere process; and a very distinct, low, lateral, sac-shaped velum at their base. This situation strongly resembles the one observed in the geographically closestC.perplexaGolovatch & VandenSpiegel, 2015, from Myanmar, but the shapes and armament of all outgrowths of the gonopodal telopodite are clearly different. A key to all threeCryptocoryphapecies known from Indochina or Myanmar and an updated checklist of all 21 species of the genus are provided.
Four new species of the trapdoor spider genus Conothele Thorell, 1878 (Araneae, Halonoproctidae) from China
Authors: Liu Hao , Xu Xin , Zhang Zengtao , Liu Fengxiang , Li Daiqin
Published: April 2019

Herein four species of the trapdoor spider genus Conothele Thorell, 1878 collected from China are described as new to science based on the female genital morphology: C.baishasp. n. (Hainan Province), C.baotingsp. n. (Hainan Province), C.linzhisp. n. (Tibet), and C.jinggangshansp. n. (Jiangxi Province). For two Hainan species, C.baishasp. n. and C.baotingsp. n., between which it is difficult to distinguish solely based on female genital morphology, additional diagnoses derived from species-specific nucleotide substitution information and genetic distances using the mitochondrial gene, cytochrome c oxidase subunit I are provided.
Do Clinical Correlates of Knee Osteoarthritis Predict Outcome of Intraarticular Steroid Injections?
Authors: Maricar Nasimah , Parkes Matthew J. , Callaghan Michael J. , Felson David T. , O’Neill Terence W.
Published: April 2019

Objective.

To determine whether clinical correlates of knee osteoarthritis (OA) affect the outcome of intraarticular steroid injections (IASI) in symptomatic knee OA.

Methods.

Men and women aged ≥ 40 years with painful knee OA who participated in an open-label trial of IASI completed questionnaires and clinical examination. The Outcome Measures in Rheumatology (OMERACT)–Osteoarthritis Research Society International (OARSI) criteria were used to assess response to therapy in the short term (within 2 weeks). Among those who initially responded, those whose pain had not returned to within 20% of the baseline Knee Injury and Osteoarthritis Outcome Score pain score at 6 months were characterized as longer-term responders. Log-binomial regression was used to examine factors associated with outcome.

Results.

One hundred ninety-nine participants were included, of whom 146 (73.4%) were short-term and 40 (20.1%) longer-term responders. Compared to short-term nonresponders, participants with these characteristics were more likely to be short-term responders: medial joint line tenderness [relative risk (RR) 1.42, 95% CI 1.10–1.82], medial and lateral joint line tenderness (RR 1.38, 95% CI 1.03–1.84), patellofemoral tenderness (RR 1.27, 95% CI 1.04–1.55), anserine tenderness (RR 1.27, 95% CI 1.06–1.52), and a belief that treatment would be effective [RR/unit increase (range 0–10) = 1.05 (1.01–1.09)]. Aspiration of joint fluid (RR 0.79, 95% CI 0.66–0.95) and previous ligament/meniscus injury (RR 0.63, 95% CI 0.44–0.91) were associated with a reduced risk of being a short-term responder. Compared to initial nonresponders and those whose pain recurred within 6 months, participants with a higher number of pain sites [RR/unit increase (range 0–10) = 0.83, 95% CI 0.72–0.97], chronic widespread pain (RR 0.32, 95% CI 0.10–0.98), perceived chronicity of disease [RR/unit increase (range 0–10) = 0.86, 95% CI 0.78–0.94], and a higher depression score [RR/unit increase (range 0–21) = 0.89, 95% CI 0.81–0.99] were less likely to be longer-term responders.

Conclusion.

Among patients with symptomatic knee OA, tenderness around the knee was associated with better short-term outcome of IASI. However, clinical-related factors did not predict longer-term response, while those with chronic widespread pain and depressive symptoms were less likely to obtain longer-term benefits.
Pain Measurement in Rheumatic and Musculoskeletal Diseases: Where To Go from Here? Report from a Special Interest Group at OMERACT 2018
Authors: Chiarotto Alessandro , Kaiser Ulrike , Choy Ernest , Christensen Robin , Conaghan Philip G. , Cowern Mary , Gill Michael , de Wit Maarten , Gargon Elizabeth , Horgan Ben , Kirkham Jamie J. , Simon Lee S. , Singh Jasvinder A. , Tugwell Peter , Turk Dennis C. , Mease Philip J.
Published: April 2019

Objective.

Establishing a research agenda on standardizing pain measurement in clinical trials in rheumatic and musculoskeletal diseases (RMD).

Methods.

Discussion during a meeting at the Outcome Measures in Rheumatology (OMERACT) 2018, prepared by a systematic review of existing core outcome sets and a patient online survey.

Results.

Several key questions were debated: Is pain a symptom or a disease? Are pain core (sub)domains consistent across RMD? How to account for pain mechanistic descriptors (e.g., central sensitization) in pain measurement?

Conclusion.

Characterizing and assessing the spectrum of pain experience across RMD in a standardized fashion is the objective of the OMERACT Pain Working Group.
PREDICTING RETINOPATHY RISK AMONG DIABETIC PATIENTS: A DATA MINING APPROACH
Authors: Foshati Saghar , Sabeti Malihe , Zamani Ali
Published: April 2019

In medicine, data collection plays an important role in the diagnosis of diseases and treatment of patients. Physicians have to cope with a large amount of patient-related data, and they often have to review the patient’s whole history or other similar cases. Data is mainly collected to find out if there are related patterns and results that can shed light on the nature of the investigated disease. Mechanized data mining has tremendous value in the diagnosis and treatment of diseases, and can be especially helpful in the diagnosis and treatment of diabetes, a disease that inflicts a large portion of the population. Now, diabetes is the fourth cause of mortality among the general population in developing countries. Retinopathy is a chronic complication of diabetes that has serious consequences including blindness if not diagnosed as early as possible. This study uses a sample of 310 Diabetic patients, half of them have the diagnosis of retinopathy ([Formula: see text]) and investigates 29 variables including age, gender, HbA1c, treatment type and etc. Our results indicate that Decorate algorithm in Weka software is the most vigorous algorithm for the purpose of the study with an accuracy rate of 0.86. The study also investigates efficacy criteria related to databases and risk factors related to this disease including age, duration of the disease, BMI, HDL level, HbA1c, FBS, 2HPPG, blood pressure, and treatment method.
Direct Oral Anticoagulants in Patients With Nonvalvular Atrial Fibrillation: Update and Periprocedural Management
Authors: Pickett Joya D.
Published: April 2019

Vitamin K antagonists (eg, warfarin) have been the standard of care for stroke prophylaxis in atrial fibrillation. The direct oral anticoagulants dabigatran (direct thrombin inhibitor) and rivaroxaban, apixaban, and edoxaban (direct factor Xa inhibitors) are as efficacious as and in some instances superior to vitamin K antagonists in the prevention of stroke, systemic embolism, and major bleeding compared with warfarin for nonvalvular atrial fibrillation. Benefits of direct oral anticoagulants include a rapid onset of therapeutic effect, fixed dose-response relationships without the need for routine monitoring, a short half-life, and infrequent need for periprocedural bridging with a parenteral agent. However, direct oral anticoagulants differ in subsets of patients. Critical care and advanced practice nurses must understand these differences, prescribing considerations, drug aherence interventions, drug-drug interactions, and periprocedural management. This article presents an update and review of direct oral antigcoagulants based on the latest national guidelines.
Percutaneous Biventricular Mechanical Heart Support in Cardiogenic Shock: A Nursing Case Report
Authors: Dittman Bridget K.
Published: April 2019

INTRODUCTION

Only a few cases of biventricular cardiogenic shock have been treated with Impella circulatory assist devices in the United States.

CLINICAL FINDINGS

A 29-year-old man came to the emergency department because of cough, shortness of breath, fever, and chills. Initial assessment revealed hypotension; an elevated creatinine level of 2.1 mg/dL; and markedly elevated results on liver function tests, with alanine transaminase 5228 IU/L and aspartate aminotransferase 6200 IU/L. The patient’s signs and symptoms met criteria for New York Heart Association class IV heart failure and associated poor prognosis for recovery.

DIAGNOSIS

Echocardiography revealed dilated cardiomyopathy and biventricular failure with an ejection fraction of 15%. Results of an endomyocardial biopsy confirmed the diagnosis of myocarditis.

INTERVENTIONS

After unsuccessful treatment with inotropes, biventricular support was started with an Impella CP device in the left ventricle and an Impella RP device in the pulmonary artery.

OUTCOMES

The patient was maintained on support for 8 days and was discharged to home from the hospital after 27 days. Repeat echocardiography 90 days after discharge indicated improvement in ejection fraction to 40%. At follow-up 16 weeks after discharge, all signs and symptoms of heart failure had resolved. The patient has not had any inpatient readmissions to the hospital to date.

CONCLUSION

This case presents an opportunity for analysis of care activities and role responsibilities of bedside nurses in caring for this patient. Discussion of this case expands the literature describing nursing activities associated with caring for patients with Impella devices.
Critical Care Nurse Work Environments 2018: Findings and Implications
Authors: Ulrich Beth , Barden Connie , Cassidy Linda , Varn-Davis Natasha
Published: April 2019

BACKGROUND

The health of critical care nurse work environments affects patient and nurse outcomes. The results of the 2018 Critical Care Nurse Work Environment Study are reported here with comparisons to previous studies and recommendations for continued improvement.

OBJECTIVE

To evaluate the current state of critical care nurse work environments.

METHODS

An online survey was used to collect quantitative and qualitative data for this mixed-methods study. A total of 8080 American Association of Critical-Care Nurses (AACN) members and constituents responded to the survey.

RESULTS

The health of critical care nurse work environments has improved since the previous study in 2013; however, there are still areas of concern and opportunities for improvement. Key findings include documented absence of appropriate staffing by more than 60% of participants; an alarming number of physical and mental well-being issues (198 340 incidents reported by 6017 participants); one-third of the participants expressed intent to leave their current positions in the next 12 months; and evidence of the positive outcomes of implementing the AACN Healthy Work Environment standards.

CONCLUSION

Evidence of the relationship between healthy nurse work environments and patient and nurse outcomes continues to increase. The results of this study provide evidence of the positive relationship between implementation of the AACN Healthy Work Environment standards and the health of critical care nurse work environments, between the health of critical care nurse work environments and job satisfaction, and between job satisfaction and the intent of critical care nurses to leave their current positions or stay.
Human capital in the banking sector cross cultural definition
Authors: Perera Ahesha
Published: April 2019

Businesses around the world proclaim their employees as being the corporation’s most valuable resource. The field of human capital (HC) is not a new one and, studies focussing specifically on HC and its importance to organisations have been published in the academic press for several decades (Amit & Zott, 2001; Barney & Wright, 1998; Otoo & Mishra, 2018; Wernerfelt, 1984). However, despite continuous research attention, HC remains underdeveloped and an under- researched concept (Gambardella, Panico, & Valentini, 2015; Lewis & Heckman, 2006; McDonnell, 2011). Specially, there is an absence of uniformity in the meanings of term human capital, thus, this exploratory research inquired from those who make use of the concept to define it. Research methods will include interviews with 10 banks in Sri Lanka and New Zealand and secondary sources. Data analysis was carried out using content analysis. The findings revealed that there is a greater likelihood of banks in both countries defined the term HC in a similar way to a greater extent though the differences exist. The findings further, offered an insight for future investigations on how the definition of a developing country differ from that of a developed country.
Cutting Edge: BCAP Promotes Lupus-like Disease and TLR-Mediated Type I IFN Induction in Plasmacytoid Dendritic Cells
Authors: Chu Talyn , Ni Minjian , Chen Chunmo , Akilesh Shreeram , Hamerman Jessica A.
Published: April 2019

Systemic lupus erythematosus severity correlates with elevated serum levels of type I IFNs, cytokines produced in large quantities by plasmacytoid dendritic cells (pDC) in response to engagement of TLR7 and TLR9 with endocytosed nucleic acids. B cell adaptor for PI3K (BCAP) promoted many aspects of TLR7-driven lupus-like disease, including Isg15 and Ifit1 expression in blood and an immature pDC phenotype associated with higher IFN production. BCAP−/− mice produced significantly less serum IFN-α than wild-type mice after injection of TLR9 agonist, and BCAP promoted TLR7 and TLR9-induced IFN-α production specifically in pDC. TLR-induced IFN-α production in pDC requires DOCK2-mediated activation of Rac1 leading to activation of IKKα, a mechanism we show was dependent on BCAP. BCAP−/− pDC had decreased actin polymerization and Rac1 activation and reduced IKKα phosphorylation upon TLR9 stimulation. We show a novel role for BCAP in promoting TLR-induced IFN-α production in pDC and in systemic lupus erythematosus pathogenesis.
Poncet’s disease diagnostic criteria decodes conundrum: Poncet’s vs pseudo Poncet’s
Authors: Shobha V. , Desai A.M.
Published: April 2019

Poncet’s disease is very important and yet a challenging diagnosis of importance in countries with high TB endemicity (e.g. India). In this case series, we present 5 patients with diagnosed as Poncet’s disease and in our tertiary health care center over 12 months and examine the performance of the diagnostic criteria suggested by Sharma and Pinto. The majority (4/5) of the patients were subsequently diagnosed and responded to anti-tuberculous therapy. In the other patient, a diagnosis of atypical seropositive rheumatoid arthritis or Pseudo Poncet’s disease was established on follow up.
Serum klotho concentrations inversely correlate with the severity of nailfold capillaroscopic patterns in patients with systemic sclerosis
Authors: Talotta R. , Rigamonti F. , Letizia T. , Bongiovanni S. , Ditto M.C. , Antivalle M. , Santandrea S. , Atzeni F. , Vago T. , Sarzi-Puttini P.
Published: April 2019

Klotho is a transmembrane and soluble glycoprotein that governs vascular integrity. Previous studies have demonstrated reduced serum klotho concentrations in patients with systemic sclerosis (SSc), and it is known that klotho deficiency can impair the healing of digital ulcers related to microvessel damage. The aim of this study was to evaluate the association between serum klotho levels and nailfold capillaroscopic abnormalities in SSc patients. We retrospectively enrolled 54 consecutive patients with SSc diagnosed on the basis of the 2013 EULAR/ACR criteria [11 with diffuse SSc; 47 females; median age 68.0 years (IQ 18); median disease duration 11.0 years (IQ 7)]. Serum klotho concentrations were determined by means of an enzyme-linked immunosorbent assay. On the basis of the 2000 classification of Cutolo et al., 14 patients had normal nailfold capillaroscopic findings, 8 had an early scleroderma pattern, 21 an active scleroderma pattern, and 11 a late scleroderma pattern. The median serum klotho concentration was 0.29 ng/mL (IQ 1). Regression analysis of variation showed an inverse correlation between serum klotho concentrations and the severity of the capillaroscopic pattern (p=0.02; t -2.2284), which was not influenced by concomitant treatment. Logistic regression did not reveal any significant association between the risk of developing digital ulcers and nailfold capillaroscopic patterns, serum klotho levels, or concomitant medications. The presence of avascular areas significantly correlated with calcinosis (p=0.006). In line with previous studies, our findings confirm that klotho plays a role in preventing microvascular damage detected with nailfold capillaroscopy.
The hominid thumb and its influence on the employment during evolution
Authors: Villafañe J.H. , Cantero-Tellez R. , Berjano P.
Published: April 2019

Not available
Should We Design Clinical Trials Differently in the Era of Cancer Immunotherapy?
Authors: Lin Chia-Chi
Published: April 2019

The oncology clinical trials are evolving in the era of cancer immunotherapy. In Phase I trials, some severe immune-related adverse events occur beyond the first cycle. This is important to determine the recommended Phase II dose if the treatment duration is long. If there is no dose–response/toxicity relationship, it will not be necessary to push to the maximum tolerated dose. In Phase II trials, companion predictive biomarkers are valuable in cancers with intermediate response rates. Randomized (comparison, selection, or discontinuation) Phase II trials are needed in cancer immunotherapy combination. In Phase III trials, milestone analysis and restricted mean survival time could serve as the alternatives to hazard ratio to fit the survival kinetics of cancer immunotherapy.
Drug Recall Monitoring and Trend Analysis: A Multidimensional Study
Authors: Eissa Mostafa E.
Published: April 2019

Background: Control of the quality of pharmaceutical and healthcare products in the market is mandatory to ensure the safety and efficacy of the delivered product to the final consumers. The United States Food and Drug Administration (FDA) is providing a continuous and comprehensive updated list for various healthcare issues including drug recalls. Methods: This study provides a multidimensional analysis using statistical process control (SPC) tools to evaluate the risk associated over a 3-year period (2016–2018). Results: The study showed a simple implementation of the combination of SPC tools, which demonstrated that the major contributors to recalls are microbiological quality issues, problems with product compositions, and packaging defects. Months that contributed by more than 60% of the total recalls were from May to August, November, and December. Conclusion: The general trend of drug recall rates is increasing yearly, which should be a warning signal for the regulatory agencies to take preventive measures to control and prevent excessive cases of recalls.
Nonlinear Robin problems with general potential and crossing reaction
Authors: Papageorgiou Nikolaos S. , Scapellato Andrea
Published: April 2019

We consider a nonlinear Robin problem driven by the

p

-Laplacian plus and indefinite potential. The reaction is parametric and exhibits an asymmetric behavior as

x\to \pm\infty

. Using variational tools together with truncation, perturbation and comparison techniques and critical groups, we show that for all small values of the parameter

\lambda > 0

, the problem admits at least four nontrivial smooth solutions, three with fixed sign and the fourth nodal. By introducing a local symmetry condition on the reaction, we show that we can have a whole sequence of distinct nodal solutions converging to zero in

C^1(\overline{\Omega})

.
The unirationality of the Hurwitz schemes $\mathcal H_{10, 8}$ and $\mathcal H_{13, 7}$
Authors: Keneshlou Hanieh , Tanturri Fabio
Published: April 2019

We show that the Hurwitz scheme

\mathcal{H}_{g,d}

parametrizing

d

-sheeted simply branched covers of the projective line by smooth curves of genus

g

, up to isomorphism, is unirational for

(g,d)=(10,8)

and

(13,7)

. The unirationality is settled by using liaison constructions in

\mathbb{P}^1 \times \mathbb{P}^2

and

\mathbb{P}^6

respectively, and through the explicit computation of single examples over a finite field.
A median approach to differentiation bases
Authors: Heikkinen Toni , Kinnunen Juha
Published: April 2019

We study a version of the Lebesgue differentiation theorem in which the integral averages are replaced with medians over Busemann–Feller differentiation bases. Our main result gives several characterizations for the differentiation property in terms of the corresponding median maximal function. As an application, we study pointwise behaviour in Besov and Triebel–Lizorkin spaces, where functions are not necessarily locally integrable. Most of our results apply also for functions defined on metric measure spaces.
Weighted extrapolation in grand Morrey spaces and applications to partial differential equations
Authors: Kokilashvili Vakhtang , Meskhi Alexander , Ragusa Maria Alessandra
Published: April 2019

In this paper we derive weighted extrapolation results in grand Morrey spaces. In particular, the main statements say that if for a class of pairs of measurable functions the one-weight inequality holds in the classical weighted

L^{p_0}_w

space for some

p_0

and for all Muckenhoupt

A_{p_0}

weights, then the one-weight inequality is also true in weighted grand Morrey space

L^{p), r, \theta}_w

with

A_p

weights for all

p

. The spaces under consideration are defined on quasi-metric measure spaces. The obtained results are applied to derive one-weight estimates for some operators of Harmonic Analysis and to study regularity properties of solutions of second order partial differential equations with discontinuous coefficients.
On the partially symmetric rank of tensor products of $W$-states and other symmetric tensors
Authors: Ballico Edoardo , Bernardi Alessandra , Christandl Matthias , Gesmundo Fulvio
Published: April 2019

Given tensors

T

and

T'

of order

k

and

k'

respectively, the tensor product

T \otimes T'

is a tensor of order

k+k'

. It was recently shown that the tensor rank can be strictly submultiplicative under this operation ([Christandl–Jensen–Zuiddam]). We study this phenomenon for symmetric tensors where additional techniques from algebraic geometry are available. The tensor product of symmetric tensors results in a partially symmetric tensor and our results amount to bounds on the partially symmetric rank. Following motivations from algebraic complexity theory and quantum information theory, we focus on the so-called
W-states
, namely monomials of the form

x^{d-1}y

, and on products of such. In particular, we prove that the partially symmetric rank of

x^{d_1 -1}y \otimes \cdots \otimes x^{d_k-1} y

is at most

2^{k-1}(d_1+ \cdots +d_k)

.
A free boundary model for the evolution of a geothermal system
Authors: Meacci Luca , Farina Angiolo , Primicerio Mario
Published: April 2019

The evolution of a geothermal system is studied. A mathematical model is proposed and the corresponding free boundary problem is formulated in a one-dimensional geometry. A situation corresponding to the geothermal field in Larderello, Tuscany (Italy) is considered, showing that the problem has two characteristic time scales, related to the motion of interface and di¤usion of vapor. Since the former is much slower, a quasi-steady approximation can be introduced and solved, obtaining a qualitative description of the evolution of the Larderello basin from a liquid-dominated to a vapor-dominated situation. This is in agreement with the geological results.
A norm estimate for evolution operators of equations with the Lipschitz property in a Banach space
Authors: Gil' Michael
Published: April 2019

In a Banach space we consider the equation

du(t)/dt= (A_0+B(t))u(t)

, where

A_0

is a constant operator, generating a

C_0

-semigroup, and

B(t)

is a bounded variable operator with the Lipschitz property. A norm estimate for the evolution operator of the considered equation is established. That estimate gives us exponential stability conditions. An illustrative example is given.