bluuebunny/crossref_metadata_2025 huggingface dataset:
Operational activities of the Soviet secret services and the Third International, including the Communist Party of Poland, against the II Republic of Poland in the interwar period – a brief outline of the problem
Authors: Sambor Konrad
Published: March 2024

The soviet special services were established, shortly after the October (November) Revolution. Thus, they became one of the key components of the Soviet state in the run-up to the Second World War. The following article is devoted to the operational activities of the soviet special services. And also The Third International, an organisation that is no less dangerous and effective as the soviet secret service. In addition, the activities of the Communist Party of Poland in the Polish state was presented. The research obtained made it possible to conclude that the eastern neighbour of the Second Polish Republic, possessing services as well as an extensive political organization, operating on a global level, was an exceptionally demanding adversary for the Polish secret services and security organs, but also for other countries.
Sirtuin 1, as a potential prognosis marker in clear cell renal cell carcinoma, regulates lipid metabolism and immune infiltration
Authors: Wang Xuefei , Deng Fangqi , Liu Jiexi , Wang Jiayu , Chen Qing , Lu Jiabin
Published: March 2024

Clear cell renal cell carcinoma (ccRCC) is a malignancy with a dismal prognosis, caused by the buildup of fat and glycogen. Sirtuin 1 (Sirt1) is a deacetylase that regulates lipid metabolism. In this study, we collected tumor and paracancer tissues from 386 ccRCC patients and followed their prognosis over an extended time period. The expression of Sirt1 in these tissues was assessed using immunohistochemistry, and LinkedOmics database analysis identified differentially expressed genes associated with Sirt1. The survival curve was generated using the Kaplan-Meier method, and immune infiltration was analyzed using the Tumor Immune Estimation Resource (TIMER) web tool. Our findings revealed that Sirt1 was expressed in tumor tissues, but not in normal tissues, and its high expression was associated with a worse prognosis. Furthermore, we observed a positive correlation between high Sirt1 expression and perirenal fat invasion and necrosis, leading to poorer survival outcomes. We established a nomogram to predict prognosis, and a correlation was observed with immune infiltration. In conclusion, our results suggest that high Sirt1 expression is associated with lipid metabolism disorder and immune infiltration, ultimately contributing to a dismal prognosis in ccRCC.
JAM3: A prognostic biomarker for bladder cancer via epithelial–mesenchymal transition regulation
Authors: Pang Zhong-qi , Wang Jian-she , Wang Jin-feng , Wang Ya-xuan , Ji Bo , Xu Yi-dan , He Jia-xin , Zhang Lu , Zhang Li-qiu , Ding Bei-chen , Liu Yang , Ren Ming-hua
Published: March 2024

Understanding the intricate relationship between prognosis, immune function, and molecular markers in bladder cancer (BC) demands sophisticated analytical methods. To identify novel biomarkers for predicting prognosis and immune function in BC patients, we combined weighted gene co-expression network analysis (WGCNA) and least absolute shrinkage and selection operator (LASSO) regression analysis. This was conducted using data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Ultimately, we screened the junctional adhesion molecule 3 (JAM3) as an independent risk factor in BC. High levels of JAM3 were linked to adverse clinical parameters, such as higher T and N stages. Additionally, a JAM3-based nomogram model accurately predicted 1-, 3- and 5-year survival rates of BC patients, indicating potential clinical utility. Functional enrichment analysis revealed that high JAM3 expression activated the calcium signaling pathway, the extracellular matrix (ECM)-receptor interaction, and the PI3K-Akt signaling pathway, and was positively correlated with genes associated with epithelial–mesenchymal transition (EMT). Subsequently, we found that overexpression of JAM3 promoted the migration and invasion abilities in BC cells, regulating the expression levels of N-cadherin, matrix metallopeptidase 2 (MMP2), and Claudin-1 thereby promoting EMT levels. Additionally, we showed that JAM3 was negatively correlated with anti-tumor immune cells such as CD8+ T cells, while positively correlated with pro-tumor immune cells such as M2 macrophages, suggesting its involvement in immune cell infiltration. The immune checkpoint CD200 also showed a positive correlation with JAM3. Our findings revealed that elevated JAM3 levels are predictive of poor prognosis and immune cell infiltration in BC patients by regulating the EMT process.
QSAR Modeling of Sphingomyelin Synthase 2 Inhibitors for Their Potential as Anti-Atherosclerotic Agents
Authors: Petrović Dejan , Ilić Marina Deljanin , Simonović Dejan , Marčetić Zoran , Stojanović Milovan , Stojanović Sanja , Arsić Nebojša , Sokolović Dušan , Veselinović Aleksandar M.
Published: March 2024

Sphingomyelin synthase 2 (SMS2) has emerged as a promising target for atherosclerosis threatment. However, the availability of selective SMS2 inhibitors and their associated pharmacological properties remains limited. This research paper explores various QSAR modeling techniques applied to a range of compounds acting as SMS2 inhibitors. Multiple distinct QSAR modeling methodologies were employed, including conformation-independent, GA-MLR and 3D based QSAR modeling, and their mutual correlations were investigated, Various statistical methods were applied to assess the quality, robustness, and predictive capacity of these developed models, yielding favorable results. Furthermore, molecular fragments derived from SMILES notation descriptors, which account for the observed changes in the evaluated activity, were defined. The methodology presented in this research holds potential for identifying novel agents for atherosclerosis treatment by targeting sphingomyelin synthase 2.
Transcriptional profile features in patients with early and late preeclampsia
Authors: Kotelnikova V. E.A. , Pantyukhova D. E. , Ablyamitova F. D. , Vikinskaya S. N. , Khalilova Kh. U. , Mustafaeva L. F. , Barieva D. A. , Yarovaya D. V. , Chopik N. D. , Ermakova M. S. , Sorokina L. E.
Published: March 2024

Aim: to assess the molecular mechanisms in developing various clinical phenotypes of preeclampsia (PE) by analyzing specific placental tissue transcriptome patterns.

   Materials and Methods. The prospective observational comparative study in parallel groups enrolled 43 pregnant women divided into 2 groups: main group – 23 pregnant women with diagnosed PE and control group – 20 apparently healthy women with uncomplicated pregnancy course, delivery and the postpartum period. To examine PE phenotypic features, the main group of pregnant women with PE was subsequently divided into 2 subgroups according to the date of pathology onset: early (n = 10) and late (n = 13) PE. Using the whole-genome next-generation sequencing (NGS), a comparative analysis of altered 18 microRNA level in placental tissue was carried out.

   Results. Pregnant women with early PE compared to the control group were characterized by significantly low expression level for hsa-miR-656-3p (p < 0.001), hsa-miR-323a-5p (p = 0.017), hsa-miR-519c-3p (p = 0.019), hsa-let-7i-5p (p = 0.019), hsa-miR-433-3p (p = 0.019), hsa-let-7g-5p (p = 0.030), hsa-miR-214-5p (p = 0.030), hsa-miR-27a-5p (p = 0.031), hsa-miR-339-5p (p = 0.041), hsa-miR-524-5p (p = 0.045), hsa-miR-1283 (p = 0.049) and high expression for hsa-miR-151a-5p (p = 0.007), hsa-miR-4521 (p = 0.018), hsa-miR-30d-5p (p = 0.026), hsa-miR-548l (p = 0.027), hsa-miR-133b (p = 0.034), hsa-miR-424-5p (p = 0.042), hsa-miR-211-5p (p = 0.049). Patients with late PE had significantly decreased expression for hsa-miR-656-3p (p = 0.050) andhsa-miR-574-3p (p = 0.017) as well as a significantly higher for hsa-miR-211-5p (p = 0.001) compared to the control group. Subgroup of women with early vs. late onset PE was characterized by significantly decreased expression level for hsa-miR-323-5p (p = 0.007) and overexpressed hsa-miR-30d-5p (p = 0.002), hsa-miR-5481 (p = 0.027).

   Conclusion. The noted multidirectional expression for some microRNAs in subgroups of PE patients confirms the validity for stratification of such pathology based on two distinct phenotypic manifestations (early and late forms) and indicates the existence of different pathophysiological vectors in PE formation.
The impact of bariatric surgery on female reproductive health
Authors: Chigisheva E. Kh. , Batyrshin I. I. , Sarvalieva A. F. , Khalitova I. V. , Zhuk T. M. , Evdokimova L. V. , Akbulatova M. A. , Zolotareva Ya. R. , Zainysheva L. M. , Baloyan S. , Dragunova E. M. , Korenkova A. A. , Bilyal N. A. , Sergeev Yu. P.
Published: March 2024

Introduction. Obesity is a worldwide problem at epidemic scale. Bariatric surgery (BS) is the most effective method to treat morbid obesity characterized by long-term and positive effects on concomitant diseases. However, the effect of BS on female reproductive health has not been sufficiently studied to date, which makes relevant to conduct further investigations in this field.

   Aim: to summarize research data assessing BS effect on female reproductive health.

   Materials and Methods. There was conducted a search for publications in the electronic databases PubMed, eLibrary and Google Scholar to identify the following keywords and their combinations in Russian and English: "bariatric surgery", "reproductive health", "sex hormones", "pregnancy", "menstrual cycle", "fetal", "neonatal". The evaluation of the articles was carried out in accordance with the PRISMA recommendations. Based on search data, 868 publications from PubMed, 83 publications from eLibrary and 74 publications from Google Scholar were retrieved. After the selection procedure, 79 articles were included in the review.

   Results. To date, the data regarding the long-term BS effects on improved obesity-related endocrine disorders remain insufficient. It is better to recommend long-acting reversible contraceptives such as intrauterine device, to post-BS patients. Women with BS history should have a continuous comprehensive nutritional assessment as well as blood macronutrients and trace elements monitoring before, during and after pregnancy. Recognizing potential complications associated with BS in the anamnesis and timely seeking specialized medical aid or timely transfer of a patient to a specialized medical facility may improve pregnancy outcomes for a mother and paired newborn.

   Conclusion. While making decision to perform BS, it is necessary to fully understand its impact on female reproductive health, assess patients' reproductive intentions and fulfill health education obligations. All patients of childbearing age who are candidates for BS should participate in a joint decision-making dialogue on BS-related risks and benefits for reproductive health, which should be supported by extensive multidisciplinary work involving obstetricians, gynecologists, endocrinologists, psychologists and representatives of other medical specialties. To date, the data regarding the BS-related effects on pregnant women are heterogeneous, which requires additional investigations in this field.
Physicians’ Adherence to Clinical Guidelines on the Chronic Heart Failure Diagnosis and Treatment: Changes Over 2 Years of the Document’s Existence
Authors: Perepech N. B. , Tregubov A. V. , Mikhailova I. E.
Published: March 2024

Aim. To study how physicians’ commitment to the basic provisions of clinical guidelines (CGs) for the diagnosis and treatment of chronic heart failure (CHF) has changed over the two years of the document existence.

Material and methods. An anonymous survey was performed for 263 physicians (204 cardiologists, 46 internists and 13 other specialists) who were trained in advanced training programs in 2022. The questionnaire included questions regarding self-assessment of the respondents’ professional knowledge, their attitude to the role of CGs in everyday practice and ideas about methods for treatment of CHF.

Results. Respondents gave 60.6 % correct answers to questions related to the treatment of CHF. More than 70% correct answers were given by 42.7% of cardiologists and 17.4% of internists. Compared to 2020, the proportion of cardiologists who gave more than 70 % correct answers increased significantly (p<0.05). CGs were considered mandatory by 26.2% and important or sometimes useful by 71.5% of respondents. Cardiologists considered CGs mandatory more frequently than internists (29.9 and 15.2 %, respectively; p=0.04). The mean number of correct answers was greater in the subgroup of respondents who considered CGs mandatory (p<0.001). More than 70% correct answers were given by only 43.8% of cardiologists, who considered themselves fully informed and able to advise colleagues on complex issues of diagnosis and treatment of CHF, and 40.6% of physicians who considered their knowledge acceptable for managing patients with CHF.

Conclusion. The majority of physician consider CGs an important methodological document but only a little more than 25 % are aware that CGs are mandatory. Cardiologists are better informed than internists about the principal provisions of National Clinical Guidelines for the diagnosis and treatment of CHF, but the average level of physician knowledge remains low.
Designing an intelligent territorial safety management system
Authors: Nicheporchuk Valery V. , Postnikova Ulyana S. , Taseiko Olga V.
Published: March 2024

The conceptual stage of designing an intelligent territorial safety management system is presented. The article shows the problems of information support for management associated with the need to process a large volume of unformalized data and their low reliability. Existing descriptions of objects and processes are not constructive. The approval and decision-making processes are poorly algorithmized and there are no feedback mechanisms reflecting the quality of decisions. As an alternative, the article proposes the use of intelligent technologies that change the mechanisms for collecting, processing and using data. An ontological description of a multi-level management model is presented that formalizes the main tasks of ensuring the natural and technogenic security of territories. Management levels and objects are highlighted, and their information support is shown. The model is based on assessments of territorial risks, representing a combination of comprehensive monitoring indicators. The novelty of the approach lies in the possibility of justifying the types and volumes of activities with the magnitude of risks, as well as linking management results with the necessary resources. The model is the basis of the intelligent system project. Using object-oriented programming methods, the transition from ontological description to structural and functional designing is shown. Representation of ontology elements in the form of sets allows the construction of multidimensional analytical models that reveal ways to solve management problems in specific conditions. This makes it possible to justify the composition of information and the requirements for its quality for each level of the territorial management hierarchy. Problem solving examples of ensuring territorial safety in accordance with the proposed classification are given. The model can be used as a scientific basis for management digitalization programs implemented in the constituent entities of the Russian Federation.
Modeling the workspace of a three-link planar manipulator
Authors: Sheveleva Tatyana A. , Lyashkov Alexey A.
Published: March 2024

A study of the working space of a three-link planar manipulator was carried out. The basis is taken from analytical dependencies that allow solving the direct problem of kinematics, i.e. determine the coordinates of the gripper center point using three generalized coordinates of the manipulator. The analysis performed made it possible to give a geometric interpretation of the dependencies. It has been established that the workspace of the manipulator is a three-parameter set of points. On a plane, this set of points is represented in the form of two disks consisting of ring cells, for which the corresponding analytical dependencies are obtained. The geometric image of this set is a three-dimensional torus. The resulting models are visualized, which facilitates the solution of this problem. To determine the values of the generalized coordinates of the gripper center points, a mapping was carried out by orthogonal projection of the families of circles obtained in the work into four-dimensional space. As a result, three-dimensional hypersurfaces in four-dimensional space were obtained. It is proposed to study them by constructing hypersurface sections models by hyperplanes. Such models in visualization mode allow solving direct and inverse kinematics problems of the manipulator under study.
Applying machine learning methods to identify argumentative connections in scientific communication texts
Authors: Salomatina Natalia V. , Sidorova Elena A. , Pimenov Ivan S.
Published: March 2024

The paper presents the results of experiments to assess the machine learning methods applicability for solving the problem of identifying argumentative connections in scientific communication texts. Argumentative connection is understood as a relationship that connects the premise and the conclusion of a typical reasoning or an argument used by the author to persuade the readers. To assess the quality, the characteristics of accuracy, completeness and F-measure were used obtained when solving the problem of recognizing argumentative connections between adjacent text fragments of two types: sentences and clauses. The basis of the experiment was a Russian-language corpus of texts from the field of scientific communication with arguments marked up by linguistic experts. For markup, the ArgNetBank Studio tool was used, which allows creating collections of texts with detailed argumentation markup. Data sets for machine learning were built on the basis of labeled texts, in which the ratio of pairs of text fragments (sentences or clauses) connected and non-connected by argumentative relationships was 1 to 3. To improve the quality of model training, the sets were balanced in two ways. In the first case, a balance was achieved due to the fact that an equal number of pairs of both types were selected from each text; in the second, pairs were duplicated. Using the obtained data sets, experiments were carried out on linking text fragments using different types of machine learning methods. The range of changes in quality assessments when recognizing related fragments depending on their share in the training and test collections was experimentally determined. It has been established that, within the framework of the existing imbalance in real collections, the values of quality assessments can vary within 40–50%. The novelty of the work lies in the study of the range of possible discrepancies in quality assessments when applying different machine learning methods on balanced and unbalanced training and test collections in Russian-language material.
Changes in the Physicochemical Characteristics of Humic Acids in a Hydrodynamic Rotor-Pulsation Apparatus
Authors: Omarov B.T. , Zhantasov K.T. , Zhantasov M.K. , Altybayev Z.M.
Published: March 2024

The work presents research results of the change comparison of brown coals and the study of the physicochemical properties of humic substances obtained from brown coals of the Karazhyra, Ekibastuz, and Kyzyl-Kiya deposits after hydrodynamic treatment in a rotary-pulsation apparatus. It is shown that the hydromechanical effect on humic acids leads to a change in their composition, accompanied by a decrease in the degree of aromaticity and an increase in the content of oxygen-containing fragments. Mechanical treatment of brown coals under oxidizing conditions maximizes the efficiency of extraction of water-soluble components and humic acids. The structural parameters and functional composition of humic acid molecules during the treatment of brown coals under oxidation-reduction conditions change depending on the conditions. The elemental and functional composition (using IR spectroscopy and potentiometry) of humic substances in brown coals and their molecular weight distribution using size-exclusion chromatography were studied. The influence of the content of metal-binding centers, dispersity, and ash content of humic substances was studied before and after treatment. At a temperature of 70 ºC a rotation time of 10 s, 98.7% of humic acids passes into the solution, which is the best indicator.
PRIMARY STUDENTS’ ALTERNATIVE IDEAS ABOUT WATER
Authors: Bosnjak Stepanovic Marija , Maricic Olja , Pesut Natalija , Balac Sanja , Kozoderovic Gordana
Published: March 2024

Alternative ideas in knowledge refer to the situations where student’s understanding of a certain concept differs from the scientific concept. During this investigation we were focused on identification and analysis of the most common students’ alternative ideas about water in early science education. The sample consisted of 76 first and third grade students from three primary schools in Sombor, Serbia. The semi-structured interviewing technique was used for data collection. The proportion of mixed and scientific answers was higher among third-graders, while the spontaneous answers were more frequent among first-graders. These findings could be attributed to developmental differences and the impact of teaching. Our investigation can be useful starting point for the process of transformation of students’ alternative ideas about water in everyday school practice.
DIFFERENCES IN OBJECTIVELY AND SUBJECTIVELY MEASURED WEIGHT AND HEIGHT IN SLOVAK ADOLESCENTS
Authors: Halmova Nora , Kanasova Janka , Kopcakova Jaroslava
Published: March 2024

The goal of our contribution is the issue of differences in objectively and subjectively measured weight (and consequently Body Mass Index /BMI/) and height in Slovak adolescents. The data obtained are a part of international study Health Behaviour in School Aged Children (HBSC) performed in Slovakia in 2017/2018. Our representative sample consisted of 782 adolescents of the fifth to ninth grades of elementary schools in Slovakia in the target group of 11 to 15 years old. We also obtained objective somatic indicators by measuring and subjective indicators were obtained using 2 item questions of the HBSC questionnaire. The results obtained point to the fact, that adolescents tend to add height and decrease weight (boys on average 0.9 kg and girls 0.6 kg) by self-reported question. However, statistically significant difference was observed in weight difference among boys girls and in total. Overweight boys tend to take almost 3 kilograms of their weight. Moreover, obese boys tend to take 5.14 kilograms and obese girls 2.40 kilograms of their weight. The results of survey show that adolescents self- assessing their height and weight tend to increase their height and decrease their weight, which is more pronounced in boys than in girls. Acknowledgments: The document is also based on the support of the grant task of MS VVS SR: VEGA 1/0460/23: „Postural health in children and adolescents and the possibilities of influencing it “
Актуальные проблемы правового регулирования социального обеспечения самозанятых в Российской Федерации
Authors: Нестерова Н.В. , Пузиков Д.А.
Published: March 2024

Статья рассматривает особенности социального страхования для самозанятых граждан в России. Авторы анализируют участие самозанятых в обязательном медицинском страховании и возможность добровольных взносов на пенсионное страхование, выявляя пробелы в законодательстве, и говоря о возможных последствиях.
СИДН: правовая природа, и его влияние на налоговую политику и бюджет в РФ
Authors: Очаковский В.А. , Сысоев И.Р.
Published: March 2024

В данной статье анализируется правовая природа СИДН, исторические аспекты формирования, условия соглашения,международный договор, который формирует отношения между государствами, последствия приостановки. В заключение говориться о возможностях, которые открывает приостановления СИДН для России, влиянии на налоговую политику и бюджет РФ.
Характеристика понятия «преступления в сфере компьютерной информации» в уголовно-правовой доктрине
Authors: Пекарева В.В.
Published: March 2024

В статье гносеологически проанализирован проблемный вопрос доктрины уголовного права существования разных подходов к пониманию содержания преступлений в сфере компьютерной информации. Рассматриваются и сопоставляются мнения исследователей, что помогает вывести единую и верную концепцию представления подобных противоправных деяний.
Использование интернета и социальных сетей в правозащитной деятельности уполномоченного по правам человека
Authors: Тимошенко А.А. , Цуканов О.В.
Published: March 2024

В статье представлен анализ правозащитной деятельности Уполномоченного по правам человека в Российской Федерации на основе привлечения Интернет-сервисов, социальных сетей и других каналов связи. Описываются практические аспекты использования таких интерактивных каналов связи и на примере деятельности Уполномоченного по правам человека Белгородской области.
Пограничные составы преступления с административным правонарушением в финансовой сфере
Authors: Черниенко А.В.
Published: March 2024

В данной научной статье рассматривается разграничение преступлений с административными правонарушениями в финансовой сфере на примере статьи 285.1. ―Нецелевое расходование бюджетных средств‖ УК РФ и статьи 15.14. ―Нецелевое использование бюджетных средств‖ КоАП РФ. В статье были проанализированы указанные правовые положения и судебная практика, а также юридическая литература таких авторов, как Кудрявцева У.К., Ярцев В.Д., Пономарев А.В., Лагутин И.Б. и другие. Целью данной работы является соотношение преступлений и административных правонарушений и определение критериев их разграничения
Pengolahan Citra Radiograf Panoramik Pada Deteksi Filling Gigi Manusia
Authors: Asti Ayu Nurul , Passarela Rossi , Sutarno Sutarno
Published: March 2024

Dengan pemrosesan citra gigi yang muncul pada kasus identifikasi manusia dalam ilmu pengetahuan forensic seperti citra X-ray gigi telah membantu secara efektif untuk mendiagnosis dan mendeteksi masalah di gigi. Pada penelitian ini akan melakukan pendekatan untuk mendeteksi filling gigi (tambal gigi) pada karies gigi di Xray Panoramik. Peningkatan dan segmentasi citra x-ray gigi digital dilakukan dengan menggunakan deteksi tepi robert. Tujuan dari ini adalah untuk meningkatkan bagian gigi yang diekstraksi dari digital rontgen gigi, menemukan tepi yang sesuai dengan gigi yang terkena tambal(filling). Proses mengekstraksi fitur, mengumpulkan dan menganalisis informasi gambar yang diharapkan dapat berguna untuk klinis diagnostik gigi dan juga merupakan kebutuhan utama ilmu kedokteran dan lainnya. Dalam penelitian ini didapatkan persentase dari dataset  program bahwa akurasi terindikasinya filling gigi yaitu 87,93%, nilai presisi 88,7% dan nilai sensitiviti sebesar 96,6% dari 116 data yang diuji.
The Clinical and Molecular Findings of Patients with Multisystem Inflammatory Syndrome in Children (MIS-C)
Authors: Fayyaz Farimah , Azizi Gholamreza , Vakili Marjan , Nikkhah Saeed , Aminpour Yasaman , Alijani Saba , Shahrooei Mohammad , Sadri Homa
Published: March 2024

Background: several children with COVID-19 disease present with fever, gastrointestinal symptoms, rash, conjunctivitis, mucosal changes, shock, and myocardial dysfunction, called multisystem inflammatory syndrome in children (MIS-C), similar to incomplete Kawasaki disease or toxic shock syndrome. The unclear pathophysiology of MIS-C prompts clinical and genetic evaluation of the patients.
Method: In the present study, patients with MIS-C disease who were referred by medical specialists of Imam Ali Hospital of Alborz in 2020-2021 were included. The clinical manifestations and laboratory findings of enrolled patients were evaluated, and the genetic analysis was performed by whole exome sequencing (WES), further confirmed by Sanger sequencing.
Results: Among 11 patients diagnosed with MISC, six patients (54.5%) were male, and the mean (SD) age of participants was 6.55 (±2.81) years. The most prevalent clinical presentations included fever (100%), rash (82%), bilateral non-purulent conjunctivitis (73%), and mucous membrane changes (64%). The only patient with genetic alterations was an 8-year-old boy with a homozygous missense variant of the ATP6AP1 gene and a heterozygous likely pathogenic canonical splice site variant of the M1B1 gene.
Conclusion: Although the young age of patients with MIS-C and their autoinflammatory presentations are similar to patients with inborn errors of immunity, the results indicate that most patients with MIS-C do not have genetic mutations.
Enhancing English Competence Based on TOEFL Result with the Use of the Expert System with Forward Chaining Method
Authors: Amalia Putri Liza , Nurrahmi Herly , Chu Xirui
Published: March 2024

This article delves into a progressive approach for enhancing English competence based on TOEFL results through the utilization of an expert system employing the forward chaining method. As a benchmark for English proficiency, TOEFL necessitates a strategic and personalized approach to address individual weaknesses. The proposed expert system analyzes TOEFL performance, identifies specific areas of improvement, and tailors learning pathways accordingly. By employing forward chaining, the system can effectively guide learners through a logical progression of targeted exercises, tailored study plans, and recommended resources to fortify identified language skill deficits. This article sheds light on how this innovative integration of technology and pedagogy can significantly bolster English language competence for TOEFL success and the overall English language proficiency.
Keywords: expert system, forward Chaining, TOEFL
``Virtual Reality as an Alternative Media for Socialization of Polimedia PSDKU Makassar CAMPUS''
Authors: Nawir Syahrir , Sakir Muh , Sulaiman Najmawati , . Adlin , Novita Rizky Anggie
Published: March 2024

This study aims to design, manufacture, and implement virtual reality as an alternative for immersive campus socialization for SMA/SMK students in South Sulawesi. The target of this study was to assess the level of acceptance and readiness of students in SMA/SMK to use virtual reality as an alternative medium for campus outreach. This study used descriptive quantitative techniques with data sources based on direct observation and data from the online questionnaires. The main stages of the research method start from topic identification, literature study, research design, data preparation, application development, implementation of applications that have been made, data collection, analysis and interpretation of data, preparation of results reports, and dissemination. The results of this study obtained data that, of the total respondents who were examined, 71.4% of the total respondents said they had never heard of the Makassar PSDKU polymedia campus; 75% of the total respondents stated that they felt as if they were walking around the Polimedia campus; meanwhile, 78.6% of the total respondents stated that they were interested in the campus using socialization media as an alternative to using a campus virtual tour. Based on the results of the study, it was concluded that virtual reality can be recommended as an alternative media for campus outreach at Polimedia PSDKU Makassar which is immersive for SMA/SMK students.
Keywords: virtual reality, immersive, media socialization
Development of an Automated Feeding System for Hydroponic Plant Nutrition Using Arduino Uno
Authors: Aisyah Siti , Suhendra Suhendra , Saharja Komda , Telaumbanua Faudunasokhi
Published: March 2024

Hydroponic farming has been a promising alternative to traditional farming, but providing plants with proper and consistent nutrition remains challenging. The issue in the research is the inaccuracy of the nutrients provided to the plants, resulting in growth that does not meet the expectations. This study aims to develop an automated nutrition system for hydroponic farming using Arduino Uno and total dissolved solids (TDS) sensors. In conducting this research, the study began with a preliminary exploration, followed by the design and integration process. Subsequently, testing and experiments were conducted on a small scale. Preliminary studies were conducted to understand existing hydroponic practices and challenges in manually supplying nutrients. The design of an automation system with Arduino Uno and a TDS sensor is made to control nutrition automatically. Automation systems are tested and calibrated to ensure accuracy and proper response. Implementation on a small scale was done with a test group and a control group in hydroponics. Growth and yield data were collected and analyzed. The results showed that the automated system provided precise and consistent nutrition, increasing plant growth and yields compared to manual methods. This research makes a scientific contribution to developing sustainable and efficient agriculture. In conclusion, nutrition automation using Arduino Uno and TDS sensors is an effective solution to increase the efficiency and productivity of hydroponic farming.
Keywords: hydroponics, automation, plant nutrition, Arduino Uno TDS sensor
Study of PG-Added Fountain Solution for Printing Offset Technique
Authors: Nugraha Mawan , . Supardianingsih , Susiani Susiani
Published: March 2024

Although the printing technology, especially offset printing, has changed and grown quickly based on advanced invention and production capacity. However, the old offset machine printing such as one or two colour offset machines are still used massively in development countries. It is unpredictable when the old printing technology eliminated completely from the community, since it is affected by the economic level and extraordinary need of the public such as public election. The old machine which has been produced for more than 10 years usually has an issue related to the ink-water balance (iwb). The use of propylene glycol (PG) as single wetting agent improved iwb based on our previous study. Therefore, the effect of PG with fountain solution to the print quality is studied here. A series of fountain solution (FS) with additional content of 0 ppm, 13 ppm, 20 ppm, 40 ppm of PG was used to print an image on the art paper surface using sakurai offset machine. The optical parameters such as optical density (OD) and L*a*b were used to observe the effect of PG content in FS to the quality of printing. The OD on 0 ppm (reference), 13 ppm, 20 ppm and, 40 ppm of PG were 1.76 (reference), 1.83, 1.76, and 1.74, respectively. The optical density was identified as the maximum value at 1.83 on raster 100% of black colour for PG 13 ppm. At 13 ppm PG-added FS, the ΔE values of black (K) and Magenta (M) were 5.2 and 9.8, respectively, while ΔE values of cyan (C) and yellow (Y) were 1.7 and 1.8, respectively. It meant at PG 13 ppm, the K and M were stronger than the reference, while C and Y were equal. The same and lower OD compared to the reference showed unimproved color.
Keywords: offset printing, fountain solution, propylene glycol
Design and Manufacture of Virus Sterilization Machine on Packaging to Prevent Transmission of Viruses and Bacteria in the Community
Authors: Santoso Habibi , Riyono Dwi , Sriyanto Widi
Published: March 2024

The increasing types of viruses and bacteria such as flu, tuberculosis or even the COVID-19 virus are quite worrying and the potential for this virus to spread is very large through product packaging, so manufacturing of virus and bacteria sterilization machines for product packaging can be a solution. Exposure to ultraviolet (UV) light type C with wavelengths below 260 nm can kill bacteria, viruses, and fungi. This research aims to create a virus and bacteria sterilization machine for packaging. The technology used is using automatic control, electric motor, conveyor, ergonomic frame, and ultraviolet (UV) light type C. This research was done by making design concepts related to machine components, making sterilization tool designs using Autocad software, and making tools to test virus sterilization machines. The creation of this machine can be an effective way to prevent the spread of viruses and bacteria that are carried and attached to the packaging during distribution.
Keywords: Keywords: machine; sterilization; virus; bacteria; packaging; ultraviolet; UV
Manufacture of Eco-cleaner Based on Eco-enzyme Reinforced Catalyst as Reduction of Metals and Impurities on Roller and Blanked to Improve Offset Quality
Authors: Siregar Efrizal , Irianto Nadeak Salam , Agustina Ika , Panjaitan Pangawet
Published: March 2024

Offset printing machines play an important role in the printing process in the printing industry, so many industrial players make various efforts to maintain the quality of offset machine printouts. One of the efforts made is to keep the rollers and blankets on the offset machine clean from metal impurities that come from printing inks. To keep rollers and blankets clean, industry players usually use chemical fluids that can clean rollers and blankets on offset machines. However, the continuous use of chemical fluids can damage the rollers and blankets due to oxidation of these chemicals over time. This affects the printing results, such as the paper getting easily damaged, the blanket becoming sticky, the print being uneven, and the density becoming low. In addition, the cleaning chemicals used can cause environmental damage such as water pollution and soil pollution. This research synthesizes an eco-cleaner from an organic waste fermentation process reinforced with a catalyst that can be used as a substitute for the chemicals used today. This research aims to produce an eco-cleaner product that can reduce metal impurities on rollers and blankets to improve the printing quality of offset machines. The resulting product works effectively to remove metal impurities without damaging the rollers and blankets because the eco-cleaner is non-corrosive. The resulting products can be used by the public and the printing industry. The method used in this research is an experiment with the fermentation synthesis method. Furthermore, the eco-cleaner is tested for characterization for feasibility according to SNI standards. The tests carried out are the organic plating test, physical properties test, test and then analysis of the test results to see the feasibility of the eco-cleaner.
Keywords: eco-cleaner, roller-blanket, printing quality, offset printing
Design of Brand Identity of Shoe Products in SR Collection
Authors: Murtopo Murtopo , Lubis Reniwati , Anwar Khairil
Published: March 2024

Every enterprise certainly needs a brand identity to become more familiar and make it easier for potential customers to identify a product, and the MSMEs Shoes SR Collection is no exception. The weaknesses of SR Collection that were found are: they did not have strong brand recognition, the shoebox design was too plain, and the promotion strategy was applied only from person to person, which is not very effective for gaining customers. Customers also identify the SR Collection shoe name with various names. Referring to this phenomenon, it can be concluded that the familiarity of SR Collection shoes is still low. Therefore, it is necessary to design a Brand Identity that can be confirmed by the SR Collection image. The promotion strategy in generating brand placement is applied to highlight and define the SR Collection brand among other competitors. The research method applied in this study is descriptive qualitative. Data were collected through interviews and observations and presented using visual design through concept maps and design boards (mood-boards). The design results that are conceptualized can highlight a new brand identity with the logo and image of SR Collection in the eyes of customers supported by designs such as logos, slogans, business cards, paper bags, packaging boxes, as well as promotional media that can be distinctive and highlight the image SR Collection Shoes.
Keywords: brand identity, promotion, MSMEs, Shoes SR Collection
Development of Website-based Risk Mitigation to Prevent Non-performing Loans at Pt. Prima Kencana Rejeki
Authors: Gusti Acfira Lukytta , Halik Fitriani , Nur Ruslinda , Khadafi Nur
Published: March 2024

Competition in the business world, especially in sales, requires people to aggressively increase sales volume. Therefore, various efforts were made by the company to further increase the level of sales. One of them is to provide convenience in the form of sales on credit even though it has credit risks, such as an increase in the number of Non-performing Loans. This research was carried out to produce a risk mitigation website that could facilitate companies in their efforts to prevent credit risk, in this case, Non-performing Loans at PT. Prima Kencana Fortune. This study used the research and development method involving collecting initial information, planning, initial product development, initial trials, and product revisions. This website consists of two user pages: the admin user page and the sales user page. The feasibility test results based on the convenience aspect have an average score of 3.18, with very good criteria. The attractiveness aspect received an average score of 2.73, a good criteria. For the usefulness aspect, the average score was 3.41, with very good criteria.
Keywords: non-performing loan, credits, risk, website
Implementation of Simagin (Industrial Internship Information System) Based on a Website at Politeknik Negeri Media Kreatif PSDKU Makassar, , Indonesia
Authors: Arysespajayadi Arysespajayadi , Irfan Abdullah Ahmad , Shabir Fadly
Published: March 2024

The research article presents the implementation of the SIMAGIN (Industrial Internship Information System) at Politeknik Negeri Media Kreatif PSDKU Makassar to address the inefficiencies in managing industrial internship activities. The system, developed using the extreme programming (XP) methodology, aims to streamline the internship process by facilitating registration, monitoring student activities, and enabling transparent information about available internship positions. The web-based system was designed to benefit students by providing efficient access to internship partner companies and enhancing the quality of their internship experiences. The research also emphasizes the use of black-box testing to ensure the system’s functionality. The study concludes that the implemented system successfully improves the industrial internship process and recommends further refinements, including the exploration of mobile applications. Overall, the research aims to significantly benefit the institution and students participating in the industrial internship program by enhancing the quality and efficiency of the internship experience.
Keywords: technology integration, student activities, internship program
An Ethnomedicinal Study; Joint Pain Therapy by Traditional Healers of Solo City
Authors: Widyowati Retno , Purwitasari Neny , Ekasari Wiwied , Agil Mangestuti , Sahu Ram Kumar , Rohmah Manis Nur , Sholikhah Irawati
Published: March 2024

Healers of Jamu- a Traditional Medicine in Solo City, Central Java, Indonesia apply several therapies for treatment of different diseases, including joint pain. The aim of the ethnomedicinal study is the identification of herbal formulations/ medicinal plants/method of preparation and their mode of administration for joint pain therapy in Jamu Medicine. An ethnomedicinal survey was conducted to collect data from traditional healers of Jamu Medicine regarding the practice of joint pain therapy. Data was collected from 25 healers through interview by snowball technique. The data obtained from the study revealed that, 25 herbal formulations /potions consisting of 32 types of medicinal plants from 19 families have been registered by traditional healers for joint pain therapy. Most commonly used plants for joint pain therapy have been identified as Piper retrofractum Vahl, Zingiber officinale Roscoe, Curcuma xanthorrhiza D.Dietr., Kaempferia galanga L., and Curcuma longa L. Traditional herbal formulations are prepared by different processing methods like washing, peeling, crushing, pounding then squeezing with warm water (infusion)/ boiling in water (decoction) to get their extract. These herbal formulations are administered orally or applied locally as massage on the affected joint. Through this study we will preserve the traditional knowledge of Jamu Medicine because the younger generation of traditional healers is no more interested in continuing it and their number is gradually decreasing. This valuable data will help the scientist to make new medicinal breakthroughs in the future especially to treat joint pain.
L-Carvone from Mentha spicata L. Leaves Suppresses Oxidative Stress and Hypertrophy in the Isoproterenol-Induced Rat Model of Cardiac Hypertrophy
Authors: Nagarajan Anitha , VA Doss
Published: March 2024

The effect of L-Carvone (a natural monoterpene from Mentha spicata L., leaves) in cardiac hypertrophy caused by isoproterenol administration was investigated. Male rats (Wistar) were divided into five groups: Control, diseased, diseased rats with losartan, diseased rats with low-dose L-Carvone, and high-dose L-Carvone. Rats were injected with isoproterenol (5 mg/kg) for 30 days to induce cardiac hypertrophy. Then, simultaneously with Losartan (15 mg/kg), L-Carvone was administered orally at a dosage of 25 mg/kg (low dose) and 100 mg/kg (high dose) treatment. The cardioprotective effect of L-Carvone was evaluated by examining the heart morphometric indices, and ECG analyses. Chronic isoproterenol administration resulted in changes in morphometric indices of the heart, ECG tracings, biochemical parameters such as tissue glucose, proteins, lipid profiles, serum cardiac markers, antioxidants, and histopathological integrity of the heart tissue. When compared with the isoproterenol group, L-Carvone administrated for 30 days ameliorated all these changes in rats significantly (p < 0.05). L-Carvone adequately averted chronic cardiac hypertrophy, most probably through its antioxidant potential.