bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of the «Yuletide story» in genre diffusion: Poverty is Not a Vice by A. N. Ostrovsky
Authors: Seifert E. I.
Published: November 2024

Purpose. The purpose of the study is to consider the role of the Yuletide story in the poetics of A. Ostrovsky’s play Poverty is Not a Vice, the tasks are to identify the Yuletide elements in this play, analyze inserted objects (artistic texts of poems and songs), plot, system of characters, lines, etc.

Results. Ostrovsky depicts a tragic situation (an irreconcilable enmity between an older brother and a younger brother who is an alcoholic; a father who gives his daughter to a rich old man without love) and leads it to a comedic outcome. The Christmas miracle has no logic, it happens suddenly – hence the implausibility of Gordey’s forgiveness of the ir-reconcilable «enemy for life» Lyubim. Yuletide elements create a festive atmosphere on stage and in the text of the work, during which good magic is possible.

Conclusion. Pride becomes a turning point in the development of intrigue in A. Ostrovsky’s play Poverty is Not a Vice. This play as a comedy is primarily characterized by a positive outcome of intrigue, enhanced by a Yuletide story so confident in genre diffusion. But the miracle here, in the genre-generic diffusion «drama (comedy) – Christmas story», is not the wedding of Mitya and Lyubov Gordeevna, but the reconciliation of Gordey Karpych with his brother Lyubim, the return of the plot of the prodigal son to its original biblical course. Under the influence of the Christmas story, the play, which is close to drama and even tragedy, turns into a comedy.
How the Historiosophy of Bunin’s Mature Works Was Shaped. Researches by Gaston Maspero in Zodiacal Light and Some Other Oeuvres
Authors: Anisimov K. V.
Published: November 2024

Purpose. Regarding Bunin’s texts’ principal dynamism and the writer’s resistance to the very idea of almost each of his works’ completeness, the author of the article attributes quotations from Maspero’s Ancient History of the Peoples of Orient revealing their alterations from early redactions of Bunin’s The Temple of the Sun to later ones. It is demonstrated how dramatic was the impact of these citations once used in order to form Bunin’s view on Egypt on «non-Egyptian» prosaic works of the 1910s.

Results. The first result reached in the course of the analysis is the accurate attribution of obscure fragments as in fact borrowed from Maspero. Secondly, it was shown how Bunin treats his precursor’s text – creating his own associations, reducing and tightening initial passages. Thirdly, the paper demonstrates how descriptions and notions derived from the book of French historian have been transformed in their very nature: diverse facts and notions have become an integral poetic imagination inspirated by scenes of decline of the Ancient World. And finally, the article investigates some traces of Bunin’s «Egyptian text» in his mature prose works – exemplifying short stories The Chalise of Life and The Dust as most representative ones.

Conclusion. The author concludes that Bunin’s intertextual poetics was specific in many respects. As it became clear in examples provided in the article, the text borrowed from another writer and «alienated» with inverted commas in fact, in its essence, was completely subordinated by Bunin to his general artistic strategy losing even slight tint of Bakhtinian «someone else’s word».
«A Sublime Look at Horror»: The Function of Ornamental Poetics in V. Zazubrin’s Story Sliver
Authors: Proskurina E. N.
Published: November 2024

Purpose. The article presents an analysis of V. Zazubrin's story Sliver (1923) from the perspective of ornamental prose on the background of the crumbling purity of literary genres.

Results. The focus on the high genre is evidenced by the capital letter of the pronoun in the subtitle of the work: «A Tale of Her and of Her», i. e. about the Revolution and Her again. In contrast to this intention, the apocalyptic imagery of the work presents the revolutionary era in the corridors of a terrifying world. The poetic layer of the text is shaped by the lyrical voice of the protagonist, enhanced by the ornamental richness of the associations. The poignancy of his inner bout, based on the attraction for revolution and repulsion from it, heightens the emotional tension of the entire work.

Conclusion. At the level of intertextual dialogue the influence of Blok's poem The Twelve on the poetics of Sliver is palpable. This is evidenced by the characteristic details of the plot: the atmosphere of the night, the street, the wind, the Chekist rampage, which correlates with the rampage of the elements, as well as the mosaicism of images and the intermittent rhythm of the narrative. Accompanying stylistic elements in the story are the poetics of contrasts, the technique of counterpoint, the density of tropes, the hyperbolization of images, which reproduce the dissonant «music» of the red terror.
Spatial Characteristics of Everyday Life in The Tale of a Sister by M. A. Osorgin
Authors: Sukhikh N. M.
Published: November 2024

Purpose. The article deals with the spatial characteristics of everyday life in The Tale of a Sister by M. A. Osorgin.

Results. The analysis of the space of everyday life in the story identified several key locations: the parents’ house, Lisa’s apartment after her marriage, Evgeny Karlovitch’s and Katya’s house. The closet is an important place for little Kostya. That is where the secret of the strong friendship between the protagonist and his elder sister was born. The author’s emphasis on the sound component is noticeable along with the absence of bright colors in the depiction of the everyday space. The ordinariness in the story most often flows silently, and unusual events are described by sound characteristics.

Conclusion. The image of everyday space in The Tale of a Sister has characteristic techniques used by the author. These are minimal detailing, lack of bright colors, and an emphasis on sounds, in particular. The minimal detailing might be the specific artistic style of M. A. Osorgin’s story. Despite the limited amount of descriptive details, the author creates a convex and tangible picture of the everyday life at that time, which fits organically into the struc-ture of the story and reflects the peculiarities of the characters’ lives.
Ivan Fyodorov’s Psalter with Book of Hours as a Miscellany: Composition and Sources
Authors: Yudin A. A. , Podoprigora V. V. , Shilova I. A. , Kovalenko A. N.
Published: November 2024

Purpose. The article studies the features of composition and structure of Ivan Fyodorov’s edition the Psalter with Book of Hours, which is considered as a particular version of the Augmented Psalter miscellany.

Results. Authors analyze main components of the edition from the point of view of their correspondence to the manuscript and early printed tradition of the Augmented Psalter of the 15th – 16th centuries and search for their possible sources. The article reveals peculiarities of composition of the texts in the Horologion part and suggests that the miscellany was specially adapted to the needs of parish churches, in which there was no need or possibility to celebrate the daily divine worship prescribed by the Jerusalem Typicon. The article identifies possible sources of the foreword part to the Psalter and concludes that Ivan Fyodorov was guided by the contemporary manuscript tradition of Augmented Psalter, but the selection and composition of the texts are original and do not yet find exact correlations in manuscripts and early printed miscellanies. The article analyses the features of composition of the superscriptions to psalms and their sources that were the commentaries of pseudo-Athanasius of Alexandria and superscriptions probably based on the glosses reflecting the exegesis of Theodoret of Cyrus.

Conclusion. The authors conclude that the edition of Psalter with the Book of Hours stands out among its contemporary manuscript and early printed analogues by its original compositions of the foreword part and particular edition of the superscriptions to psalms.
Morphometric evaluation of the proximal tibiofibular joint among patients with knee joint pain: A pilot study and literature review
Authors: Sojat Jakub Krzysztof , Szlęzak Michał Jan , Zamarlik Marta Izabela , Bressler Kamil , Zieliński Maciej , Rajca Jolanta , Wilk Renata , Ficek Krzysztof , Likus Wirginia
Published: November 2024

Objectives:

The proximal tibiofibular joint (PTFJ) serves as a crucial stabilizing component of the entire knee joint complex. Morphometric analysis of the PTFJ can lead to clinically significant conclusions for orthopedic specialists and physiotherapists. The aim of the study was to assess the values of the inclination angle of the PTFJ in the sagittal and coronal planes using magnetic resonance imaging in patients with knee pain.

Material and Methods:

Measurements of the inclination angle were conducted on 48 patients divided into three groups: Those with damaged medial meniscus (M), those with knee joint cartilage damage (Ca), and the control group (C), in which no deviations from normality were observed in the analyzed imaging study.

Results:

The mean values of the tibiofibular joint inclination angle in the frontal plane were as follows: (C) 16.927° ± 1.778; (Ca) 16.822° ± 2.537; (M) 14.958° ± 1.760. In the sagittal plane, the corresponding values were: (C) 38.155° ± 1.524; (Ca) 39.392° ± 1.927; (M) 37.471° ± 1.165. Although the mean tibiofibular joint inclination angle was lowest in the group with medial meniscus injury when compared to the control group, these differences did not reach statistical significance.

Conclusion:

Measuring and observing the variety of PTFJ inclination angles among patients are conducive to better understanding its influence on knee pain. The differences in the PTFJ inclination angle between groups in our pilot study were not statistically significant. Consequently, the study necessitates replication within a substantial population cohort.
Topical 5-fluorouracil as monotherapy for ocular surface squamous neoplasia
Authors: Laxamana Francis Ezra Miciano , Mercado Gary John Vergel
Published: November 2024

Ocular surface squamous neoplasia (OSSN) comprises a gamut of diseases, which encompass conjunctival intraepithelial neoplasia, conjunctival carcinoma in situ, and squamous cell conjunctival neoplasia. Gold standard treatment for OSSN entails excision with cryotherapy. A lot of progress has been made recently that shows that chemotherapeutic drugs, such as mitomycin C, 5-fluorouracil (5-FU), and interferon alfa2b, can be just as effective. This is a case report that includes two cases: An 81-year-old Filipino female and a 65-year-old Filipino male who presented with a pinkish lesion on the bulbar conjunctiva. Documentation was done through clinical observation, slit-lamp examination, and the use of anterior segment optical coherence tomography (OCT). 1% topical 5-FU was given as chemotherapy administered at 1 drop 4×/day for 1 week with a 3-week drug holiday. During the course of treatment, we noted clinical resolution of the lesions grossly on slit-lamp examination. On anterior segment OCT, a decrease in diameter and thickness was noted, but with remaining areas of hyperreflectivity and thickened epithelium at the site of the lesion. No decrease in visual acuity was noted during the course of treatment, as well as any adverse effects such as eye pain or inflammation. Considering its safety and efficacy profile, 5-FU has great potential to be considered as a first-line therapy in the topical treatment of OSSN. Topical chemotherapy can target microscopic diseases that may be missed surgically and decrease adverse effects. As seen in this case report, 5-FU shows much promise as a possible alternative in the treatment of OSSN.
P-SELECTIN AND INTEGRIN-β3 LEVELS IN BLOOD PLASMA IN PATIENTS WITH CORONARY ARTERY DISEASE AFTER PERCUTANEOUS CORONARY INTERVENTION
Authors:   Addis Ababa Silk Road General Hospital, Addis Ababa, Ethiopia, Chernyak A. A.
Published: November 2024

Background. Coronary artery disease (CAD) is a leading cause of mortality and disability worldwide. Modern treatment methods, such as percutaneous coronary intervention (PCI), have significantly improved patients’ outcomes. However, the risk of stent restenosis remains a significant problem. Objective. To determine the levels of biochemical markers (P-selectin and integrin-β3) in the plasma of patients with coronary artery disease (CAD) after percutaneous coronary intervention (PCI), and to evaluate the effectiveness of various models for predicting in-stent restenosis. Material and methods. The study included 209 CAD patients divided into four groups: healthy individuals, patients with chronic CAD without indications for invasive coronary angiography, patients with CAD who underwent elective PCI, and patients with in-stent restenosis. Plasma levels of P-selectin and integrin-β3 were measured using enzymelinked immunosorbent assay (ELISA). Results. In-stent restenosis occurred in 12 patients (8.05%) after elective PCI. Analysis showed that P-selectin and integrin-β3 levels did not have statistically significant differences between patient groups. The predictive model including BMI, ventricular extrasystole, number of stents, diabetes mellitus, and multifocal atherosclerotic coronary artery disease showed the best key metrics efficiency. Conclusion. P-selectin and integrin-β3 levels did not show significant differences in patients with in-stent restenosis. The model including BMI, VE, number of stents, DM, and MFCAD is the most effective for predicting restenosis recurrence.
PRIMARY HYPERALDOSTERONISM. CLINICAL CASE IN MEDICAL PRACTICE
Authors:   Grodno State Medical University, Grodno, Belarus, Nikonova L. V. , Tishkovskiy S. V. ,   Grodno State Medical University, Grodno, Belarus, Davydchyk E. V. ,   Grodno State Medical University, Grodno, Belarus, Martinkevich O. N. ,   Grodno University Clinic, Grodno, Belarus, Lukjanchuk J. M. ,   Grodno University Clinic, Grodno, Belarus, Evseychik M. G. ,   City Polyclinic № 7 of Grodno, Belarus
Published: November 2024

This article presents a clinical case of adrenal gland growth identification with the development of primary hyperaldosteronism in a patient admitted to the Endocrinology Department of the health care institution “Grodno University Clinic”. The team of authors has outlined diagnostic search tactics for making a diagnosis and administering adequate treatment for suspected primary hyperaldosteronism in a patient with arterial hypertension.
الالتزام الصحي للحماية من فيروس كورونا وعلاقته بالمرونة المعرفية لدى عينة من الراشدين وكبار السن من المجتمع الكويتي
Authors: العجمي راشد مانع راشد , العتيبي عبد الله حزام علي
Published: November 2024

هدفت هذه الدراسة إلى التعرف على مستوى كل من الالتزام الصحي والمرونة المعرفية لدى عينة الراشدين وكبار السن من أفراد المجتمع الكويتي، والكشف عن الفروق في مستوى كل من الالتزام الصحي والمرونة المعرفية وفقاً لمتغيرات (الجنس- الجنسية- العمر- المستوى التعليمي)، وكذلك التعرف على العلاقة بين الالتزام الصحي وبين المرونة المعرفية. ولتحقيق أهداف الدراسة، قام الباحثان بإعداد أداتين: مقياس الالتزام الصحي، ومقياس المرونة المعرفية، واستخراج دلالات صدقهما وثباتهما. تكونت العينة من (198) فرداً من المجتمع الكويتي. أظهرت نتائج الدراسة إن مستوى الالتزام الصحي لدى أفراد المجتمع الكويتي مرتفع، ولا توجد فروق إحصائية ذات دلالة معنوية في مستوى الالتزام الصحي وفقاً لمتغيرات الجنس، والجنسية، والمستوى التعليمي، بينما توجد فروق إحصائية ذات دلالة معنوية في مستوى الالتزام الصحي وفقاً لمتغير العمر ولصالح الفئة العمرية (40-50) سنة. كما أشارت النتائج بإن مستوى المرونة المعرفية لدى أفراد المجتمع الكويتي مرتفعة، وتوجد فروق إحصائية ذات دلالة معنوية في مستوى المرونة المعرفية، وفقاً لمتغير الجنس ولصالح الإناث، ووفقاً لمتغير العمر ولصالح الفئة العمرية (40-49) سنة، بينما لا توجد فروق إحصائية ذات دلالة معنوية في مستوى المرونة المعرفية وفقاً لمتغيري الجنسية والمستوى التعليمي. وأشارت النتائج أيضًا إلى وجود علاقة ارتباط عالية وموجبة بين الالتزام الصحي وبين المرونة المعرفية.
Quantitative Compliance Based Classification of Submental Sign or Javid Sign
Authors:   Department of Anesthesiology and intensive care, Tehran University of Medical Sciences, Iran, MJ Javid , Z Khazaeipour ,   Brain & Spinal Cord Injury Research Center, Neuroscience institute, Tehran University of Medical Sciences, Iran
Published: November 2024

Prediction of difficult intubation is still a dilemma. Despite various predictors of difficult airway reported and discussed in the literature, no definite test exists to prevent mortality and morbidity related to difficult airway. Using a combination of different predictors of difficult intubation is logical to help minimizing this difficulty and establishing a safe anesthesia. Detection and presentation of any novel predictor can be helpful in achieving this goal. “Submental Sign” or “Javid Sign” a new predictor of difficult intubation, was reported by MJ Javid in 2011, but qualitative characteristic of this predictor was the most considerable drawback for using Submental Sign as an accurate predictor. The goal of this study is quantitative classification of Submental Sign or Javid classification to overcome false positive and false negative results of Submental Sign. In this article a novel scale is introduced for evaluating submental compressibility quantitatively.
Analysis of Hydrophobicity in Micropores of Metal-Organic Framework Materials
Authors: Rutherford Steven William
Published: November 2024

Water molecules in hydrophobic micropores of Metal Organic Framework (MOF) materials show disparate behavior in adsorption equilibrium. Ranging from behavior indicative of large, Type V uptakes occurring at low relative pressure, to Type III equilibrium where little water is adsorbed, this phenomenon provides a challenge for a priori prediction. In an effort to elucidate adsorption mechanisms, this study advances a quantitative description of hydrophobicity through novel application of Ising model analysis (IMA). It is applied to scrutinize hydrophobicity indicated by Type III adsorption and displayed by micropores that are too large to induce a Type V water adsorption equilibrium. Two types of hydrophobicity are identified and partitioned into surface and structural hydrophobicity, with quantitative assessment delivered by analysis of a data set covering 26 materials. Application of a modified Kelvin analysis (MKA) indicates that bulk water properties and macroscopic contact angles can characterize the equilibrium behavior of water in molecular level micropores of nanostructured MOF materials. Additionally, the concepts of nanocapillarity and nanowetting are established and prove capable of further characterizing the hydrophobicity of these materials. Finally, the methods and analyses applied to these phenomena in MOF micropores could foreseeably aid in screening studies, be used to assess the presence of cooperative, wetting, and condensation-like mechanisms and be further employed to estimate contact angles and scrutinize phenomena associated with hydrophobicity in other microporous, nanostructured materials.
Predictive modeling of the probability of gynecological complications of tamoxifen therapy: A prospective study
Authors: Golubenko Ekaterina O. , Savelyeva Marina I. , Korennaya Vera V. , Podzolkova Natalia M. , Valiev Timur T.
Published: November 2024

Background. It is well known that adjuvant therapy for breast cancer (BC) with tamoxifen is associated with an increased risk of endometrial hyperplasia (EH). Currently, the problem of hyperplastic processes and endometrial cancer during long-term tamoxifen therapy is particularly relevant since the incidence of endometrial disorders has a direct correlation with the duration of tamoxifen therapy. Follow-up by a gynecologist should be tailored to consider the risk of endometrial cancer in women who survived BC to improve the early detection of endometrial cancer and avoid unnecessary invasive procedures.
Aim. To predict adverse drug reactions (ADRs) of tamoxifen, including EH, endometrial polyps, and abnormal uterine bleeding, based on mathematical modeling in relation to the carriage of polymorphic variants of cytochrome P450 enzyme genes and drug transporter proteins.
Materials and methods. A prospective pharmacogenetic study of 120 women with stage I–III luminal BC receiving tamoxifen was conducted. The polymerase chain reaction method was used to detect the presence of polymorphisms of cytochrome P450 genes, followed by an assessment of their associations with ADRs of tamoxifen, namely with local gynecological symptoms.
Results. Predictive models of ADR occurrence based on the logistic regression function have been created and validated by ROC analysis. We have developed a prognostic model to estimate the probability of developing a composite endpoint (polyp, EH, abnormal uterine bleeding) based on history and genetic risk factors. It was found that the predictors of the combination of local gynecological ADRs (EH, endometrial polyp, and abnormal uterine bleeding) include such factors as weight loss, the presence of asthenia, an increase in the number of births, carriage of the TT genotype of the ABCB1 3435 polymorphic variant and the GG genotype of the CYP2D6*4 polymorphic variant, GG of the CYP3A5 polymorphic variant. The relatively high incidence (43.3%) of local gynecological symptoms requires regular monitoring by obstetrician-gynecologists using instrumental methods (transvaginal ultrasound).
Conclusion. This prognostic model has demonstrated high diagnostic effectiveness, which allows it to be implemented in the routine clinical practice of an obstetrician-gynecologist.
Comparison of efficacy and safety of regorafenib and anti-EGFR targeted therapy in metastatic colorectal cancer: A retrospective study
Authors: Kuzmina Evgeniya S. , Fedyanin Mikhail Yu. , Lyadova Marina A. , Fedorinov Denis S. , Polyanskiy Maxim A. , Parts Sergey A. , Pokataev Ilya A. , Galkin Vsevolod N.
Published: November 2024

Aim. To compare the efficacy of regorafenib and the combination of chemotherapy (CT) with anti-EGFR (cetuximab/panitumumab) in the third-line treatment of metastatic colorectal cancer (mCRC).
Materials and methods. A retrospective analysis of a prospective database of patients with mCRC from two clinics in the Russian Federation was conducted. Overall survival was considered the primary efficacy criterion. Additional criteria were progression-free survival (PFS), objective effect (OE), and incidence of toxicity. No statistical hypothesis was assumed. Statistical analysis was performed using SPSS (IBM SPPS Statistics v. 20).
Results. The database identified 51 patients with morphologically confirmed left-sided mCRC with wild-type RAS and BRAF genes who received more than two lines of antitumor drug therapy from 2010 to 2021, one of which included anti-EGFR antibodies in the third and subsequent lines of treatment. Thirty patients who received regorafenib in the third line and 21 patients who received CT in combination with anti-EGFR in the third line were selected, of which 7 patients had a history of anti-EGFR use, and 14 patients received anti-EGFR for the first time. The median overall survival from the third line initiation date in the CT group in combination with anti-EGFR was numerically higher (21 months, CI 9.0–32.9 months) than in the regorafenib group (10 months, CI 2.4–17.5 months); p=0.1 by log-rank test (Mantel–Cox test); p=0.2 by Breslow–Wilcoxon test; p=0.3 (Tarone–Ware test). PFS was also higher in the anti-EGFR CT group (6 months, CI 3.8–8.2 months) than in the regorafenib group (3 months, CI 1.2–4.7 months); p=0.05 according to Breslow–Wilcoxon test. OE of third-line therapy was reported in 57.1% (n=12) of patients in the CT with anti-EGFR group and significantly less often in the regorafenib group – 10.3% (n=3) of patients (p=0.001). The toxicity of drug therapy of all grades in the regorafenib group was reported in 86.2% (n=25) of patients, while in the CT anti-EGFR group, it was significantly less common – in 52.4% (n=11) of patients (p=0.01).
Conclusion. Compared with regorafenib, combining CT with anti-EGFR agents in the third-line treatment of patients with left-sided mCRC with wild-type RAS and BRAF genes is associated with better PFS and the frequency of OE with significantly less toxicity.
Clinical significance of PET/CT in the diagnosis of primary adrenal malignancies
Authors: Ognerubov Nikolai A. , Antipova Tatiana S. , Mirsalimova Olga O. , Poddubnaya Irina V.
Published: November 2024

Background. According to the literature, the role of combined positron-emission and X-ray computed tomography (PET/CT) in diagnosing primary adrenal tumors (AT) remains limited due to both the frequency of these neoplasms and the availability of the method. Various research is required to assess the diagnostic resources of PET/CT with 18-fluorodeoxyglucose (18F-FDG).
Aim. To evaluate the clinical role of PET/CT with 18F-FDG in the diagnosis of primary adrenal malignancies (PAM).
Materials and methods. The study included 9 patients, 5 males and 4 females aged 44–76, with a median age of 59.3 years, with a morphologically confirmed diagnosis of the PAM. All patients underwent PET/CT with 18F-FDG. Visual and quantitative analysis of the obtained images was performed, including determination of the standardized maximum accumulation coefficient (SUVmax) in the tumor, liver, and spleen, the ratio of SUVmax of the primary tumor to SUVmax in the liver and spleen. Tumors were more often localized on the right (5/55.6%), and one case was bilateral. The maximum size of the adrenal mass averaged 6.8 cm (3.2–11.2) and the minimum size was 6.0 cm (2.3–9.0). The median SUVmax in AT was 10.0 (3.54–22.29), while in liver and spleen, it was 3.16 and 2.34, respectively, and the ratio of tumor SUVmax to liver and spleen SUVmax was 3.33 and 4.48, respectively.
Conclusion. Hybrid PET/CT with 18F-FDG is a medical imaging method with a high diagnostic accuracy of PAM. PET/CT showed significant 18F-FDG tumor uptake, with a median SUVmax of 10.0 and a ratio of tumor SUVmax to liver and spleen SUVmax of 3.33 and 4.48, respectively. PET/CT with 18F-FDG may be a method of choice for diagnosing primary ATs.
Tolerability of perioperative chemotherapy for gastric cancer in real clinical practice
Authors: Fedorinov Denis S. , Lyadova Marina A. , Lyadov Vladimir K.
Published: November 2024

Background. The choice of the optimal scheme of perioperative chemotherapy of locally advanced gastric cancer is an urgent problem in real clinical practice.
Aim. To analyze therapy tolerability in this cohort of patients.
Materials and methods. Perioperative chemotherapy of gastric cancer was performed in 90 patients in the Chemotherapy Department of the Oncology Center №1 of the Yudin City Clinical Hospital from January 2021 to February 2024.
Results. The incidence of severe complications at the preoperative stage was 41.9% for the FOLFOX regimen and 40.7% for the FLOT regimen, at the adjuvant stage – 17.4 and 43.2%, respectively. Operative treatment was successfully performed in 79 (87.8%) patients, and the full scope of combined treatment of locally advanced gastric cancer was completed in 59 (65%) patients. 80.8% of pathomorphologic responses in the FOLFOX group and 67.9% in the FLOT group were TRG3-4, with complete response noted in only one patient.
Conclusion. High toxicity rates in elderly and comorbid patients on the FOLFOX regimen require the development of an individualized approach to the treatment of this group of patients.
Comparison of the efficacy of neoadjuvant chemotherapy with FLOT regimen and adjuvant chemotherapy with XELOX/FOLFOX regimen in patients with locally advanced gastric cancer: A retrospective study
Authors: Semenov Nikolay N. , Izrailov Roman E. , Semenov Nikolay E. , Zhukova Liudmila G. , Feoktistova Polina S. , Matveychuk Danila A. , Khatkov Igor E.
Published: November 2024

Background. To date, there is no consensus on the preferred sequence of combined treatment in patients with locally advanced gastric cancer (perioperative chemotherapy – POCT or primary surgical treatment). No direct comparison of these approaches had been conducted before.
Aim. To compare, in retrospective analysis, 3-year relapse-free (RFS) and overall survival (OS) in patients receiving POCT FLOT or adjuvant chemotherapy XELOX/FOLFOX for locally advanced gastric cancer.
Materials and methods. The assessment included 153 patients who underwent POCT FLOT and 171 patients who underwent surgical treatment at the first stage. When evaluating the initial characteristics, it was shown that patients with ECOG (The Eastern Cooperative Oncology Group) stage 1-2, clinical stage cT4a-b, cN2-3 and Bormann type 4 to were significantly more common in the POCT group. Morphological characteristics: grade, presence of signet cell carcinoma, HER2/neu overexpression, microsatellite instability, sensitivity to immunotherapy (Combined Positive Score) didn't differ.
Results. With a median follow-up of 40 months, it was shown that the long-term results assessed in all included patients were better in the group with primary surgical treatment: 3-year RFS was 55 and 40% (risk ratio – RR 1.33, 95% confidence interval – CI 1.08–1.64; р=0.007). 3-year OS was 68 and 56% (RR 1.36, 95% CI 1.02–1.8; р=0.04), respectively. However, when evaluating patients who received surgical treatment in the POCT group (n=121, 79%), the results did not differ: 3-year RFS 55 and 50% (RR 0.9, 95% CI 0.71–1.16; р=0.97), 3-year OS 68 and 63% (RR 1.1, 95% CI 0.84–1.59; р=0.97). Insufficient volume of adjuvant chemotherapy (75% of the dose) significantly worsened long-term results (3-year OS 43 and 71%; p=0.002).
Conclusion. The obtained data of a retrospective analysis did not reveal the advantages of any of the approaches provided that the surgical stage was performed in patients receiving POCT. To obtain more objective results, it is necessary to conduct randomized multicenter studies in the high volume centers, providing the necessary sample capacity, quality of diagnosis and treatment. Thus, the design of future studies should be based on the hypothesis of non-inferiority, which inevitably entails a significant increase in the required number of observations to obtain reliable sampling power.
Role of enzyme replacement therapy for exocrine and nutritional insufficiency in patients with malignancies: A review
Authors: Khatkov Igor E. , Maev Igor V. , Bordin Dmitry S. , Kononenko Inessa  B. , Kucheryavyy Yury  A. , Pokataev Ilya  A. , Snegovoy Anton  V. , Tryakin Alexey  A. , Feoktistova Polina  S. , Zhukova Liudmila  G.
Published: November 2024

Exocrine pancreatic insufficiency (EPI) is a condition in which the amount of secreted pancreatic enzymes is insufficient to maintain normal digestion. EPI is a frequent complication of pancreatic or other malignancies. The presence of EPI in a cancer patient may be suggested by symptoms of maldigestion, malabsorption, and alteration of nutritional markers; however, it is important to note that the EPI symptoms may be subtle. In the early stages, EPI may be latent and manifested by malnutrition. However, even in the later stages, the symptoms of EPI may be similar to those of cancer or be masked by the condition after chemoradiation therapy. Antitumor therapy itself may also cause EPI. Enzyme replacement therapy (ERT) is the standard of care for EPI, but it is rarely prescribed to cancer patients. However, supportive therapy plays an essential role in treating cancer patients because the quality of life and life expectancy of patients largely depend on the adequacy of the complex treatment. The review discusses the possible causes of EPI and its diagnosis and treatment in cancer patients. Special attention is paid to ERT regimens, including those for improving digestion and the drug's dosage form. It is shown that pancreatin in minimicrospheres is the drug of choice for ERT, since the minimum particle size facilitates the most physiological digestion process.
Retrospective analysis of the safety and efficacy of Pembroria® during non-medical switching from the original drug Keytruda® in patients with advanced malignancies of various localizations in real clinical practice
Authors: Zhukova Liudmila G. , Filonenko Daria A. , Polshina Natalya I. , Smolin Sergei A. , Pasechnyuk Olga S.
Published: November 2024

Introduction. The emergence of genetically engineered biological drugs is rightly considered a revolutionary event in medicine. In 2022, the first biosimilar of pembrolizumab, the Russian drug Pembroria®, was approved. One of the study types that can convincingly demonstrate the safety and efficacy of biosimilar is its use for switching from the original drug for non-medical indications (NMS, or non-medical switching) according to standard approaches of real clinical practice and the drug label.
Aim. To assess the safety of NMS switching in patients with advanced malignancies of various localizations from the original drug Keytruda® to the biosimilar Pembroria® and to evaluate its effectiveness in real clinical practice.
Materials and methods. We analyzed the data of 114 patients with advanced malignancies of various localizations and the last line of treatment with Keytruda® as monotherapy or in combination with other agents within the approved indications and switched to Pembroria® for NMS. After switching to Pemboria®, patients did not change treatment for another checkpoint inhibitor within this line of therapy.
Results. The incidence of immune-mediated adverse reactions (imARs) of any severity during treatment with comparators differed slightly: 57% with Keytruda® and 54% with Pembroria®. The majority of imARs with both Keytruda® and Pembroria® were Grade 1 in severity (69% and 86%, respectively). All serious ARs were resolved and did not result in drug discontinuation. When analyzing the best objective response to treatment with Keytruda®, complete response, partial response, and stabilization were observed in 9 (7.9%), 28 (24.6%), and 61 (53.5%) cases, respectively, during treatment with Pemboria® – in 8 (7%), 24 (21%), 52 (45.6%) cases, respectively.
Conclusion. The safety profile of Keytruda® and Pembroria® is acceptable and comparable: the imAR rate with Pembroria® when switching from Keytrada® did not exceed that with the original drug Keytruda®; in most patients, switching from Keytruda® to Pembroria® was not associated with an increase in the imAR rate or severity. The majority of patients maintained disease control when switched to Pembroria®.
On the Identity of Blue Striped Snappers (Pisces: Perciformes: Lutjanidae) of India
Authors: Barman R. P. , Das A. , Mishra S. S.
Published: November 2024

No Abstract.
Diving Beetles of Karnala Bird Sanctuary, Maharashtra, India (Coleoptera: Dytiscidae)
Authors: Ghosh Sujit Kr. , Hegde V. D.
Published: November 2024

No Abstract.
Dermaptera Fauna of Chhattisgarh with some New Records
Authors: Lal B. , Hegde V. D. , Chandra K.
Published: November 2024

No Abstract.
New Records of Hairy Wasps (Hymenoptera: Scoliidae) from DIU, India
Authors: Girish Kumar P. , Sharma Gaurav
Published: November 2024

No Abstract.
Fruit-Flies (Insecta: Diptera: Tephritidae) of Chhattisgarh
Authors: Halder Sumana , Bhattacharya Kaushik Kr. , Parui P. , Chandra Kailash , Banerjee Dhriti
Published: November 2024

No Abstract.
A Note on the Occurrence of Spotted Seahorse, Hippocampus Kuda (Bleeker, 1852), along the Sindhudurg Coast, Maharashtra
Authors: Roy Sanmitra , Kumar Nitesh , Satam Abhishekh N. , Tripathy Basudev
Published: November 2024

No Abstract.
First Record of Triacanthus nieuhofii Bleeker, 1852 (Tetraodontiformes: Triacanthidae) from Northern East Coast of India
Authors: Ranjan Mohanty Swarup , Mohapatra Anil , Sekhar Mishra Subhrendu
Published: November 2024

The Silver tripodfish, Triacanthus nieuhofii Bleeker, 1852, is reported for the first time from the West Bengal coast along the northern part of the Bay of Bengal, based on two specimens collected from Shankarpur fishing harbour and Digha Mohana, Digha, West Bengal, India. This species might co-exist in the entire Bay of Bengal coast and but often confused as Triacanthus biaculeatus due to very similar external morphology.
Gymnothorax zonipectis Seale, 1906 (Anguilliformes: Muraenidae) - an addition to the Eel Fauna of Andaman and Nicobar Islands and India
Authors: Rajan P. T. , Bharucha Johann , Bineesh K. K. , Mishra S. S.
Published: November 2024

A moray eel species, Gymnothorax zonipectis Seale, 1906, is reported for the first time from India based on photographic evidence from Neil Island, Andaman and Nicobar Islands, and expands its geographical distribution further westward. The description, habitat ecology and distributional range of the eel also provided establishing its first record from India. An annotated checklist of moray eels from these islands is also appended.
On a report of Pterorana khare Kiyasetuo and Khare, 1986 (Amphibia: Anura: Ranidae) from Bandarkhal, Southern Assam, India
Authors: Saikia Bhaskar , Jacinta Kharkongor Ilona , Imam Imtiaz
Published: November 2024

Report of any threatened taxon is important from both taxonomic and conservation point of view. Pterorana khare is a vulnerable species of frog. It has been reported from a few disjunctive pockets of all the North-East India states, except Tripura. Besides, there are single reports of this species from Bangladesh and Myanmar. In Assam, this species was previously reported from Nameri National Park on the north bank of River Brahmaputra, while from the south bank, we are reporting it for the first time, based upon specimens collected from Barail Wildlife Sanctuary.
Range extension of Ictinogomphus decoratus (Selys, 1854) (Insecta: Odonata: Gomphidae) to India
Authors: Babu R. , Srinivasan G. , Subramanian K. A.
Published: November 2024

Ictinogomphus decoratus (Selys, 1854) (Insecta: Odonata: Gomphidae) is widely distributed in South East Asia. Here we report the range extension of the species to Indian Territory and new addition to the Indian Odonate fauna from the Little Andaman, Andaman and Nicobar Islands.
First record of Butis koilomatodon (Bleeker, 1849) (Gobiiformes: Eleotridae) from West Bengal, India
Authors: Samim Hossin Sk , Ray Dipanjan , Ranjan Mohanty Swarup , Mohapatra Anil , Sekhar Mishra Subhrendu
Published: November 2024

Occurrence of Butis koilomatodon (Bleeker, 1849) (Gobiiformes: Eleotridae) is reported for the first time from West Bengal, India based on two specimens collected from Sankarpur fishing harbour. Systematic account of the species is provided for distinction. Only eight species in the family Eleotridae were known from West Bengal earlier and the present report adds one more to the list.
Contribution to the knowledge on Indian Marine Molluscs : Family Conidae
Authors: Venkitesan R. , Barua S. , Hafiz Md.
Published: November 2024

This study was aimed to compile the information on the diversity and distribution of Indian cone shells (Family Conidae) from the materials present in National Zoological Collections (NZC) of Zoological Survey of India (ZSI). About 93 species were known from India and a total of 76 species are reported in this study and it revealed that the species distribution is more on the Andaman and Nicobar islands (37), 12 species from Andhra Pradesh, 32 species from Tamil Nadu, 8 species each from Puducherry, Maharashtra and Lakshadweep, 5 species from Kerala and Gujarat respectively and one species each of Odisha and Karnataka. Beside above, systematic taxonomic account, nomenclature, synonymy, distinctive features and their distribution along with their current status are also discussed.
Megophrys maosonensis Bourret, 1937 (Anura: Megophyridae) - A New India Record from Talley Valley Wildlife Sanctuary, Arunachal Pradesh, India
Authors: Saikia Bhaskar , Sinha Bikramjit , Thakur Mukesh , Kharkongor Ilona Jacinta
Published: November 2024

Megophrys longipes maosonensis, described from Mao Son, Vietnam is long considered to be a junior synonym of Megophrys major species complex. However, recently, it has been resurrected from its synonymy into a valid species, with its distribution restricted to Vietnam and the adjacent areas of China. In 2015, we have made a sample collection of Megophrys from Talley Valley Wildlife Sanctuary in Arunachal Pradesh on which we performed DNA barcoding using fragments of mitochondrial 12S rRNA and 16S rRNA. This has resulted in the specimen being identified as M. maosonensis making it a new record for India.
On the Occurrence of Asterropteryx semipunctata RÃ¼ppell, 1830 (Gobiiformes: Gobiidae: Gobiinae), from the Gulf of Mannar, Southeast Coast of India
Authors: Das Mrinal Kumar , Mishra Subhrendu Sekhar
Published: November 2024

One specimen of Asterropteryx semipunctata RÃ¼ppell, 1830 (Gobiiformes: Gobiidae) was collected from Vallimunai Island, Gulf of Mannar, southeast coast of India in December 2018. The present paper reports A. semipunctata for the first time from the Gulf of Mannar, Tamil Nadu, southeast coast of India with morphometric and meristic characters.
Some Noteworthy Bat (Mammalia: Chiroptera) Records from Manipur State, Northeastern India
Authors: Saikia Uttam , Ngaomei Gaikhuanlung , Meetei A. B.
Published: November 2024

Specimen based records of five species from Manipur state namely Rhinolophus sinicus, R. yunanensis, Kerivoula picta, Myotis muricola and Miniopterus magnater is presented. The mensural data of the examined specimens from Manipur and comparative data from India and Nepal are also provided. With the current additions, the bat inventory of Manipur stands at 17 species. This also highlights the paucity of information on the bat species diversity and distribution of bat fauna in the state and calls for extensive field based studies.
Report on Sicklefin Weasel Shark Hemigaleus microstoma (Bleeker, 1852) (Carcharhiniformes: Hemigaleidae) from the Andaman Islands, Indian EEZ with DNA Barcodes
Authors: Bineesh K. K. , Kiruba Sankar R. , Nashad M. , Arun Retheesh O. R. , Kumar Ravi Ranjan , Basheer V. S.
Published: November 2024

The occurrence of sickle fin weasel shark Hemigaleus microstoma Bleeker, 1852 is reported here from Indian EEZ, off the Andaman Islands in the Bay of Bengal. Two specimens of total length (TL) 610 mm and 628 mm were caught by longline at depths 40-100 m. A detailed diagnostic description and morphometrics of H. microstoma and its comparison with previous literature is provided. COI DNA barcodes were generated for the collected specimens.
New Records of Aquatic and Semi-Aquatic Heteroptera (Insecta: Hemiptera) from Mainland India
Authors: Eyarin Jehamalar E. , Chandra Kailash
Published: November 2024

Four species of the aquatic and semi-aquatic Hemiptera such as Anisops occipitalis Breddin (1905), Hydrometra okinawana Drake (1951), Neoalardus typicus (Distant, 1903) and Limnometra ciliata Mayr (1865), of families Notonectidae, Hydrometridae, Veliidae and Gerridae respectively, are the first records from mainland India and were collected from different districts of Meghalaya. The recorded species are very rare and have been collected from a single locality.
Note on the record of Blythia hmuifang Vogel, Lalremsanga, Vanlalhrima, 2017 from Lunglei District, Mizoram, India
Authors: Raha Sujoy , Das Sunandan , Bag Probhat
Published: November 2024

One specimen of Blythia hmuifang Vogel et al. (2017) has been traced from among the collections of Zoological Survey of India collected from Lunglei district of Mizoram, India which forms the largest specimen known and slightly differ from the original description. The taxonomic details of the specimen presented in this paper show such differences amounting to extended range of scale counts.
First report of the genus Paratrypauchen Murdy, 2008 (Gobiiformes: Gobiidae: Amblyopinae) from the Odisha coast, India
Authors: Ruidas Haradhan , Ranjan Mohanty Swarup , Rana Saumyapriya , Roy Sanmitra , Mohapatra Anil
Published: November 2024

Present study reports a comb goby, Paratrypauchen microcephalus (Bleeker, 1860), from Odisha coast for the first time. The genus Paratypauchen Murdy (2008) is monospecific, with scaleless abdomen and a subdermal or only slightly exposed, smooth frontal crest. The paper deals with the meristic and morphological details of P. microcephalus from Odisha coast in details.
A new species of the genus Annina (Crustacea: Isopoda: Cirolanidae) from the Hugli River of West Bengal, India
Authors: Mitra Santanu , Tabassum Shahnaz
Published: November 2024

Annina hugliensis sp. nov., an isopod belonging to the family Cirolanidae, is described from the materials collected from the muddy tidal bank of the Hugli river, at Barrackpore, West Bengal, India. The new species can be distinguished from other species of the genus Annina Budde-Lund 1908 in having a pair of distally sub-furcated dorso-lateral horns on perionite 2 of males, that reaching not more than half of the length of perionite 1; appendix masculina arising sub-medially and extending well beyond endopod of pleopod 2. The new species herein compared with all the existing species of this genus including the most similar species Annina fustis Bowman & Iliffe (1991). An identification key to all the species of the genus Annina is provided.
Range extension and first record of Meretrix lusoria (RÃ¶ding, 1798) (Mollusca: Bivalvia: Veneridae) from Indian coastal waters
Authors: Rupavath Rajendar Kumar , Rajan Rajkumar , Jegadeesan Vanishree
Published: November 2024

Meretrix lusoria (RÃ¶ding, 1798), one of the commercially important marine bivalves found in waters of west Taiwan, southeast China, Thailand and Japan, is reported for the first time from the coastal waters of India (Andhra Pradesh coast, Bay of Bengal), thus extending its range from Central Indo-Pacific to Bay of Bengal. This report raises the tally of Meretrix spp. so far known from India to four.
On the Polyclads from the Gulf of Mannar Biosphere Reserve with new records
Authors: Padmanaban P. , Anand Kumar A. , Rajendar Kumar R. , Surendar C. , Vanishree J.
Published: November 2024

The present paper deals with the study of 10 species of polyclad flatworms found in the coral reef and inter-tidal areas of Gulf of Mannar Biosphere Reserve based on collections from Thalayari Island made during February 2017 to April 2019. This study reports five species, viz. Phirkocerous katoi, Pseudobiceros hymanae, Pseudoceros bicolor, Pseudoceros galatheensis and Thysanozoon brocchii, as new distributional records from Gulf of Mannar Biosphere Reserve.
Diversity of Orthopteran insects and their role in Tea Agro-Ecosystem of West Bengal
Authors: Das Swapan Kumar , Shah Suresh Kumar , Chakraborty Rajdip , Das Apurva , Mitra Bulganin
Published: November 2024

Documentation on the diversity of the Order Orthoptera and their role in tea agro-ecosystem of West Bengal is meager. The surveys cum collection tours conducted from 2012-2016 in three districts, Darjeeling, Jalpaiguri and Alipurduar, of West Bengal to explore insect diversity in tea agro-ecosystem of this area. The study reports 39 species under 33 genera belongs to 7 families of Orthoptera. Of which, 5 species under 4 genera are reported for the first time from West Bengal and 3 are endemic. Considering their role in this unique ecosystem orthopteran insects have been found both as herbivorous and carnivorous species.