bluuebunny/crossref_metadata_2025 huggingface dataset:
Economic development management in a water-capacious economy
Authors: Fedulova Svitlana , Dubnytskyi Volodymyr , Komirna Vitalina , Naumenko Nataliia
Published: August 2019

The world tendencies of spatial development, namely the availability of limited resources (primarily water) and the growth of the world’s food needs focus on the resource specialization of the region. On this basis, the purpose of the article is to study the impact of the water-capacious economy on the economic development of the country and its regions. The study used the traditional and special methods, including: historical and logical method – to analyze the functioning of regional socio-economic systems under limited water resources; and system analysis methods – to evaluate the impact of the water-capacious economy on the economic development of the country and its regions. The research results have important implications for the management of the territories. The authors show that the production specialization of the regions of Ukraine on the export/import of water-capacious products is not determined by their water supply. They also suggest that stimulating the region’s water-efficient activity should lead to a minimization of the water capacity of gross regional product and the reproduction of water capital, taking into account the water security of the regions. The authors also show that the water resources of the country and its regions and the natural water potential of the territories in the current situation become significant restriction to the economic development of territories, which allows to state the need to change the approaches to the regulation of regional development based on limited water resources.
AKULTURASI ISLAM JAWA DALAM TRADISI NYUMBANG MANTU (Studi Kasus Masyarakat Wates Semarang dengan Pendekatan Antropologi Dakwah)
Authors: Safrodin Safrodin
Published: August 2019

This study aims to explain one of the embodiment of acculturation of Islamic and Javanese culture in the tradition of mantu and nyumbang mantu on Javanese society at Wates Semarang with anthropological perspective. Mantu in the tradition of the Javanese society includes mantu khitanan and mantu ngantenan. It has an important meaning in the eyes of the people. In addition to the cultural demands, in it also has the meaning of religion, custom and meaning of prestige for them, so that as much as possible they will hold a mantu though must with gotong royong. Gotong royong has long been formed in the tradition of nyumbang mantu. This tradition of nyumbang mantu is a manifestation of brotherhood and solidarity in society, as well as a social obligation accompanied by other expectations such as social prestige, social dignity and blessings. The nyumbang mantu is also a manifestation of the ta'āwun principle in a society that has been institutionalized in tradition and culture. On the other hand, the transformation of mantu from simple slametan to walīmah, which is accompanied by religious teachings [pengajian] of mantenan and religious entertainment, especially in santri society, is actually a form of acculturation of Java and Islam. This acculturation occurs as a process of strengthening to the Islamic values in society. Because, the certain values that society believes will only survive when it grows and develops into a culture in society.
Integrated numerical model for irrigated area water resources management
Authors: Huo Aidi , Wang Xiaofan , Liang Yan , Jiang Cheng , Zheng Xiaolu
Published: August 2019

The likelihood of future global water shortages is increasing and further development of existing operational hydrologic models is needed to maintain sustainable development of the ecological environment and human health. In order to quantitatively describe the water balance factors and transformation relations, the objective of this article is to develop a distributed hydrologic model that is capable of simulating the surface water (SW) and groundwater (GW) in irrigation areas. The model can be used as a tool for evaluating the long-term effects of water resource management. By coupling the Soil and Water Assessment Tool (SWAT) and MODFLOW models, a comprehensive hydrological model integrating SW and GW is constructed. The hydrologic response units for the SWAT model are exchanged with cells in the MODFLOW model. Taking the Heihe River Basin as the study area, 10 years of historical data are used to conduct an extensive sensitivity analysis on model parameters. The developed model is run for a 40-year prediction period. The application of the developed coupling model shows that since the construction of the Heihe reservoir, the average GW level in the study area has declined by 6.05 m. The model can accurately simulate and predict the dynamic changes in SW and GW in the downstream irrigation area of Heihe River Basin and provide a scientific basis for water management in an irrigation district.
A hybrid optimization approach for parameter estimation of confined and leaky confined aquifers
Authors: Ayvaz M. Tamer , Gurarslan Gurhan
Published: August 2019

The main objective of this study is to propose a linked simulation–optimization approach for solving aquifer parameter estimation problems from pumping test results. In the simulation part of the proposed approach, the drawdowns at given monitoring points and times are calculated by considering the Theis and Hantush approaches for confined and leaky confined aquifers, respectively. This simulation part is then integrated to a newly proposed hybrid optimization approach, namely DE–Solver, which integrates the differential evolution (DE) algorithm and generalized reduced gradient (GRG) method of the spreadsheet Solver add-in. The performance of the proposed approach is evaluated by considering two pumping test data for confined and leaky confined aquifers. Identified results indicate that the proposed approach provides better results than those obtained by using different approaches in the literature.
Constraints, performance and perspectives of anaerobic sewage treatment: lessons from full-scale sewage treatment plants in Brazil
Authors: Bressani-Ribeiro T. , Chamhum-Silva L. A. , Chernicharo C. A. L.
Published: August 2019

There are hundreds of full-scale upflow anaerobic sludge blanket (UASB) reactors in operation in various parts of the tropical world, notably in India and Latin America, Brazil being the holder of the largest park of anaerobic reactors for sewage treatment in the world. Despite the recognized advantages of UASB reactors, there are problems that have prevented their maximum operational performance. Neglecting the existence and delaying the solution of these challenges can jeopardize the important advances made to date, impacting the future of anaerobic technology in Brazil and in other countries. This work aims to evaluate the operational performance of five full-scale UASB reactors in Brazil, taking into account a monitoring period ranging between two and six years. The main observed design, construction, and operational constraints are discussed. Some outlooks for important upcoming developments are also provided, considering that most of the observed drawbacks can be tackled without significant increases on reactor costs.
Yetişkinlerin Aile Değerlerinin Kişisel Bazı Değişkenlere Göre İncelenmesi
Authors: Özyürek Arzu , Özpınar Hüseyin , Okcu Arife , Kabakuş Büşra Seher , Öksüzoğlu Şerife , Fikir Serap , Akarsu Şevki , Karaoğlu Mehmet , Yağımlı Mehmet Akif , Şahin Hülya
Published: August 2019

Bireyin bakım ve gelişiminin desteklenmesinde olduğu gibi değer eğitiminde
de birinci derecede sorumlu kurum aile olarak görülmekte, bireyin değer
kazanımı ailede başlamaktadır. Bireylerin görüşleri ise tutum ve davranışlarına
yansımaktadır. Bu nedenle bu çalışmada, yetişkinlerin aile değerlerine ilişkin
görüşlerini bazı kişisel değişkenlere göre incelemek amaçlanmıştır. Betimsel
tarama modelindeki çalışmada, çalışma grubu 18 yaş üzeri 201 kişiden oluşmuştur. Verilerin
toplanmasında Aile Değerleri Ölçeği
kullanılmıştır. Verilerin analizinde t-testi ve tek yönlü varyans analizi
(ANOVA) kullanılmıştır. Sonuç olarak; aile değerlerinin cinsiyet, yaş, öğrenim
düzeyi, meslek ve çocuk sayısına göre farklılaştığı belirlenmişti. Kadınların
Karar Alma Süreçleri, Evliliğe Bakış, Kadının Rolleri, Duygusal Bağ ve Şiddet
alt boyutlarının erkeklerin puanından; erkeklerin Anne-Çocuk İlişkisi alt
boyutu puanının kadınların puanından anlamlı düzeyde yüksek olduğu
saptanmıştır. Yaşı 30 ve üzeri olanların Anne-Çocuk İlişkisi alt boyut puanı,
31 yaş ve üzeri yetişkinlere göre daha yüksek bulunmuştur. Lisans mezunu
yetişkinlerin Şiddet alt boyut puanlarının ilköğretim mezunlarından,
profesyonel meslek grubundaki yetişkinlerin Evliliğe Bakış ve Kadının Rolleri
alt boyut puanlarının çalışmayan ve memur olanlardan daha yüksek olduğu
belirlenmiştir. Üç ve daha fazla çocuğu olan yetişkinlerin Cinselliğe Bakış alt
boyut puanı tek çocuğu olanların puanına göre daha yüksek bulunmuştur. İki
çocuğa sahip yetişkinlerin Anne-Çocuk İlişkisi puanı diğerlerinden düşük, hiç
çocuğu olmayanların Akraba İlişkileri puanı ise bir çocuğu olanların puanına
göre anlamlı düzeyde daha düşük bulunmuştur.
Coffea arabica Bean Extracts and Vitamin C: A Novel Combination Unleashes MCF-7 Cell Death
Authors: El-Garawani Islam M. , El-Nabi Sobhy H. , El-Shafey Samraa , Elfiky Mohamed , Nafie Ebtesam
Published: August 2019

Background::

Vitamin C (VC) is believed to enhance immunity and is regularly integrated as a supplementary agent during several treatments.

Objective::

The green (GC) and roasted (RC) coffee (Coffea arabica) aqueous extracts (0, 125, 250 and 500 μg/ml) combined with VC (50 μg/ml) were examined on the cancerous MCF-7 cell line and normal human lymphocytes.

Methods::

Neutral red uptake assay, comet assay, immunocytochemical reactivity for protein expression and mRNA expression of apoptosis-related genes were performed.

Results::

A significant (P< 0.05) concentration-dependent increase of apoptotic features, such as morphological changes, and abundant nuclear condensation, altered the expression of p53 and caspase-3 mRNA, down-regulation of Bcl-2 protein as well as the acidic autophagosomal vacuolization in treated cells. The oxidative stress and DNA single-strand breaks were noticed too.

Conclusion::

These results suggest that coffee in combination with VC undergoes apoptotic anticancer pathway. This supports the integration of coffee and VC as a valuable candidate for anticancer research and treatments.
Recent Patents on Impact of Lipopeptide on the Biofilm Formation onto Titanium and Stainless Steel Surfaces
Authors: Pires Mauro Ezio Eustáquio , Parreira Adriano Guimarães , Silva Tuânia Natacha Lopes , Colares Heloísa Carneiro , da Silva José Antonio , de Magalhães Juliana Teixeira , Galdino Alexsandro Sobreira , Gonçalves Daniel Bonoto , Granjeiro José Mauro , Granjeiro Paulo Afonso
Published: August 2019

Background:

Numerous causes of infection in arthroplasties are related to biofilm formation
on implant surfaces. In order to circumvent this problem, new alternatives to prevent bacterial
adhesion biosurfactants-based are emerging due to low toxicity, biodegradability and antimicrobial
activity of several biosurfactants. We revised all patents relating to biosurfactants of applicability
in orthopedic implants.

Methods:

This work aims to evaluate the capability of a lipopeptide produced by Bacillus subtilis
ATCC 19659 isolates acting as inhibitors of the adhesion of Escherichia coli ATCC 25922 and
Staphylococcus aureus ATCC 29213 onto titanium and stainless steel surfaces and its antimicrobial
activity.

Results:

The adhesion of the strains to the stainless-steel surface was higher than that of titanium.
Preconditioning of titanium and stainless-steel surfaces with 10 mg mL-1 lipopeptide reduced the
adhesion of E. coli by up to 93% and the adhesion of S. aureus by up to 99.9%, suggesting the
strong potential of lipopeptides in the control of orthopedic infections. The minimal inhibitory
concentration and minimum bactericidal concentration were 10 and 240 µg mL-1 for E. coli and
S. aureus, respectively.

Conclusion:

The lipopeptide produced by Bacillus subtilis ATCC 19659 presented high biotechnological
application in human health against orthopedic implants infections.
Cost-effective Heuristic Workflow Scheduling Algorithm in Cloud Under Deadline Constraint
Authors: Meena Jasraj , Vardhan Manu
Published: August 2019

Background:

Cloud computing is used to deliver IT resources over the internet. Due to
the popularity of cloud computing, nowadays, most of the scientific workflows are shifted towards
this environment. Many algorithms have been proposed in the literature to schedule scientific workflows
in the cloud, but their execution cost is very high as they are not meeting the user-defined
deadline constraint.

Aim:

This paper focuses on satisfying the user-defined deadline of a scientific workflow while minimizing
the total execution cost.

Methods:

So, to achieve this, we proposed a Cost-Effective under Deadline (CEuD) constraint
workflow scheduling algorithm.

Results:

The proposed CEuD algorithm considers all the essential features of the Cloud and resolves
the major issues such as performance variation and acquisition delay.

Conclusion:

We compared the proposed CEuD algorithm with the existing literature algorithms for
scientific workflows (i.e., Montage, Epigenomics, and CyberShake) and obtained better results for
minimizing the overall execution cost of the workflow while satisfying the user-defined deadline.
Potential Effects of Magnesium on Gestational Diabetes Mellitus
Authors: TUNCER Esra , YARDIMCI Hülya
Published: August 2019

Magnesium, which is the cofactor for many
enzymes in the body is involved in important mechanisms such as regulation of
body temperature, synthesis of nucleic acid and protein. Magnesium also plays
an important role in the metabolism of carbonhydrate and lipids. Its role in
such situations as diabetes mellitus is remarkable. Magnesium is suggested to
play a role in glucose homeostasis due to the effects of insulin secretion and
glucose uptake by cells. Although not in all cases, diabetes mellitus is often
thought to be associated with magnesium deficiency. In addition, the inverse
relationship between dietary magnesium intake and the risk of type 2 diabetes
mellitus is indicated. Gestational diabetes mellitus, a type of diabetes
mellitus, is a common complication during pregnancy. Gestational diabetes
mellitus, which negatively affects health of both maternal and newborn is
associated with increased risk of macrosomia, preeclampsia, caesarean delivery
and neonatal hypoglycemia. Maternal magnesium deficiency could be a risk factor
both for maternal and newborn health. Hypomagnesemia in pregnancy is reported
to be a potential contributing factor to problems such as hypertensive
disorders, gestational diabetes mellitus, preterm delivery and intra uterine
growth retardation. In this review, potential effects of magnesium on
pregnancy, diabetes mellitus and gestational diabetes mellitus will be
discussed.Vücutta birçok enzimin kofaktörü olan
magnezyum, vücut sıcaklığının düzenlenmesi, nükleik asit ve protein sentezi
gibi önemli mekanizmalarda görev almaktadır. Karbonhidrat ve lipit
metabolizmasında da görev aldığı için diabetes mellitus gibi durumlarda rolü
dikkat çekmektedir. İnsülin sekresyonu ve hücrelerin glukoz alımında etkisi
nedeni ile magnezyumun glukoz homeostazında rol aldığı düşünülmektedir. Tüm
vakalarda olmamakla birlikte, genellikle diabetes mellitusun magnezyum
eksikliğiyle ilişkili olduğu düşünülmektedir. Ayrıca diyetle magnezyum alımı ve
tip 2 diabetes mellitus riski arasında ters ilişki olduğu belirtilmektedir. Diabetes
mellitusun bir türü olan gestasyonel diabetes mellitus (GDM) gebelik döneminde
sık karşılaşılan bir komplikasyondur. Hem anne hem bebek sağlığını olumsuz
yönde etkileyen gestasyonel diabetes mellitus; makrozomi, preeklampsi, sezaryen
doğum, neonatal hipoglisemi riskinde artış ile ilişkilendirilmektedir. Maternal
magnezyum eksikliği hem annenin hem de bebeğin sağlığı için risk oluşturabilir.
Gebelikte hipomagnezeminin hipertansif bozukluklar, gestasyonel diabetes
mellitus, preterm doğum, intrauterin büyüme geriliği gibi sorunlara katkıda
bulunabilen bir faktör olduğu belirtilmektedir. Bu derlemede, magnezyumun
gebelik dönemi, diabetes mellitus ve gestasyonel diabetes mellitus üzerindeki
olası etkileri tartışılacaktır.
Social Media Use and HIV Screening Uptake Among Deaf Adults in the United States: Cross-Sectional Survey Study
Authors: Argenyi Michael , Kushalnagar Poorna
Published: August 2019

Background

About 46% of US adults obtain recommended HIV screening at least once during their lifetime. There is little knowledge of screening rates among deaf and hard-of-hearing adults who primarily use American Sign Language (ASL), or of social media as a potentially efficacious route for HIV prevention outreach, despite lower HIV/AIDS-specific health literacy and potentially higher HIV seropositivity rates than hearing peers.

Objective

We investigated both the likelihood of HIV screening uptake among deaf adults in the past year and over one year ago, and the relationship between social media use and HIV screening uptake among deaf adult ASL users.

Methods

The Health Information National Trends Survey in ASL was administered to 1340 deaf US adults between 2015-2018. Modified Poisson with robust standard errors was used to assess the relationship between social media usage as a predictor and HIV screening as an outcome (screened more than one year ago, screened within the past year, and never been screened), after adjusting for sociodemographics and sexually transmitted disease (STD) covariates.

Results

The estimated lifetime prevalence of HIV screening uptake among our sample was 54% (719/1340), with 32% (429/1340) in the past year. Being of younger age, male gender, black, lesbian, gay, bisexual, or queer, or having some college education or a prior STD were associated with HIV screening uptake. Adjusting for correlates, social media use was significantly associated with HIV screening in the past year, compared to either lifetime or never.

Conclusions

Screening falls well short of universal screening targets, with gaps among heterosexual, female, Caucasian, or older deaf adults. HIV screening outreach may not be effective because of technological or linguistic inaccessibility, rendering ASL users an underrecognized minority group. However, social media is still a powerful tool, particularly among younger deaf adults at risk for HIV.
Comparing Methods for Record Linkage for Public Health Action: Matching Algorithm Validation Study (Preprint)
Authors: Avoundjian Tigran , Dombrowski Julia C , Golden Matthew R , Hughes James P , Guthrie Brandon L , Baseman Janet , Sadinle Mauricio
Published: August 2019

BACKGROUND

Many public health departments use record linkage between surveillance data and external data sources to inform public health interventions. However, little guidance is available to inform these activities, and many health departments rely on deterministic algorithms that may miss many true matches. In the context of public health action, these missed matches lead to missed opportunities to deliver interventions and may exacerbate existing health inequities.

OBJECTIVE

This study aimed to compare the performance of record linkage algorithms commonly used in public health practice.

METHODS

We compared five deterministic (exact, Stenger, Ocampo 1, Ocampo 2, and Bosh) and two probabilistic record linkage algorithms (fastLink and beta record linkage [BRL]) using simulations and a real-world scenario. We simulated pairs of datasets with varying numbers of errors per record and the number of matching records between the two datasets (ie, overlap). We matched the datasets using each algorithm and calculated their recall (ie, sensitivity, the proportion of true matches identified by the algorithm) and precision (ie, positive predictive value, the proportion of matches identified by the algorithm that were true matches). We estimated the average computation time by performing a match with each algorithm 20 times while varying the size of the datasets being matched. In a real-world scenario, HIV and sexually transmitted disease surveillance data from King County, Washington, were matched to identify people living with HIV who had a syphilis diagnosis in 2017. We calculated the recall and precision of each algorithm compared with a composite standard based on the agreement in matching decisions across all the algorithms and manual review.

RESULTS

In simulations, BRL and fastLink maintained a high recall at nearly all data quality levels, while being comparable with deterministic algorithms in terms of precision. Deterministic algorithms typically failed to identify matches in scenarios with low data quality. All the deterministic algorithms had a shorter average computation time than the probabilistic algorithms. BRL had the slowest overall computation time (14 min when both datasets contained 2000 records). In the real-world scenario, BRL had the lowest trade-off between recall (309/309, 100.0%) and precision (309/312, 99.0%).

CONCLUSIONS

Probabilistic record linkage algorithms maximize the number of true matches identified, reducing gaps in the coverage of interventions and maximizing the reach of public health action.
Health Workers’ Perceptions on Data-informed Decision Making practice in Primary Health Care Units at Awi Zone, Northwest Ethiopia (Preprint)
Authors: Guadie Habtamu Alganeh , Gashu Kassahun Dessie , Shiferaw Atsede Mazengia
Published: August 2019

BACKGROUND

Background: Data-informed decision making is influenced by organizational, technical and behavioral factors. Behavioral factors are the major contributing ones for data-informed decision making practice.

OBJECTIVE

This study aimed to explore health workers’ perception on data-informed decision making at primary health care units of Awi zone.

METHODS

Method: A qualitative study was undertaken to explore health workers’ perception on the barriers of health data-informed decision making practice. Eleven healthcare workers were purposively selected from Primary Hospital, Health centers and Health posts. Medical Doctors, Nurses, Midwifes and Health Extension Workers were selected as key informant for in-depth interview. The selected healthcare workers were asked about their perceptions that affect health data use practice. A thematic analysis was carried out using OpenCode software. Analysis was performed with three identified themes namely; organizational, behavioral and technical themes.

RESULTS

Results: All the respondents were aware of data-informed decision making at the point of care. Some had experienced taking notes from their customers, and most witnessed they are negligent to write all details. They also expressed their feelings that registration book timely availability had an impact on their utilization practice of data-informed decision making.

CONCLUSIONS

Conclusion: Health workers are well aware of the practice of data-informed decision making at the point of service delivery. Behavioral, organizational and technical factors major contributing ones.

CLINICALTRIAL
Understanding Students’ Mental Well-Being Challenges on a University Campus: Interview Study (Preprint)
Authors: Park Sun Young , Andalibi Nazanin , Zou Yikai , Ambulkar Siddhant , Huh-Yoo Jina
Published: August 2019

BACKGROUND

Research shows that emerging adults face numerous stressors as they transition from adolescence to adulthood. This paper investigates university students’ lived experiences of maintaining mental well-being during major life events and challenges associated with this transitional period. As we continue to design health technology to support students’ mental health needs, it is imperative to understand the fundamental needs and issues particular to this phase of their life to effectively engage and lower the barriers to seeking help.

OBJECTIVE

This study first aimed to understand how university students currently seek and receive support to maintain their mental well-being while going through frequent life events during this period of emerging adulthood. The study then aimed to provide design requirements for how social and technical systems should support the students’ mental well-being maintenance practice.

METHODS

Semistructured interviews with 19 students, including graduate and undergraduate students, were conducted at a large university in the Midwest in the United States.

RESULTS

This study’s findings identified three key needs: students (1) need to receive help that aligns with the perceived severity of the problem caused by a life event, (2) have to continuously rebuild relationships with support givers because of frequent life events, and (3) negotiate tensions between the need to disclose and the stigma associated with disclosure. The study also identified three key factors related to maintaining mental well-being: time, audience, and disclosure.

CONCLUSIONS

On the basis of this study’s empirical findings, we discuss how and when help should be delivered through technology to better address university students’ needs for maintaining their mental well-being, and we argue for reconceptualizing seeking and receiving help as a colearning process.
Pensiones en México 1995-2018: ocaso de una estrategia fallida
Authors: Leal Fernández Gustavo
Published: August 2019

En este trabajo se revisan algunas aristas del desafío pensionario mexicano en pleno siglo XXI. Ellas confirman la urgencia de aplicar una revisión integral del Sistema de Ahorro para el Retiro (SAR) edificado a partir de los –poco prometedores resultados– de la reforma al imss (1995) y su posterior extensión al issste (2007). Además de los babyboomers que pasarán a retiro próximamente, un gran pendiente se proyecta sobre las nuevas generaciones de millennials y su nublado horizonte pensionario
Estrategias de intervención para disminuir la violencia y la delincuencia: avances y desafíos en República Dominicana
Authors: Ortiz Rodríguez Magnolia
Published: August 2019

El objetivo de este estudio es analizar diversas estrategias de prevención de la violencia y la delincuencia, que cuenten con respaldo científico de su eficacia. Se hace una comparación de estos con los programas “Seguridad Democrática” y el “Plan de Seguridad Ciudadana” de República Dominicana. Es un estudio de tipo documental, basado en fuentes secundarias y se utilizan las técnicas de análisis y comparación. Los resultados más importantes revelan que durante la ejecución del Plan Seguridad Democrática, la tasa de homicidios aumentó en un 26 %. Sin embargo, durante la ejecución del Plan de Seguridad Ciudadana, la tasa de sobrepoblación penitenciaria ha aumentado en un 22 %.

Dentro de los avances del Plan de Seguridad Ciudadana, se destaca la utilización de las TIC. Además, se utilizan los enfoques de persecución del delito y la intervención basada en la comunidad. Los desafíos más importantes son integración de los diferentes sectores en las diversas fases del plan. La utilización del diseño experimental en la evaluación de los programas y verificación de su impacto. Diseño de estrategia en el tercer nivel y disminución de la sobrepoblación penitenciaria.
FAKTOR-FAKTOR PEMBENTUKAN DAERAH OTONOMI BARU DAN DAMPAKNYA TERHADAP KEUANGAN NEGARA
Authors: Maulana Arief
Published: August 2019

Reformasi sistem Pemerintahan Republik Indonesia yang di antaranya ditandai dengan perubahan dari sistem sentralisasi menjadi desentralisasi telah berimbas pada trend pemekaran daerah. Tapi, mulai akhir tahun 2014 pemerintah menerapkan kebijakan moratorium pembentukan Daerah Otonomi Baru (DOB) dengan alasan untuk fokus menyelesaikan masalah besarnya defisit anggaran sebelum mencabut moratorium tersebut. Tujuan kajian ini adalah untuk menganalisis faktor-faktor pendorong pembentukan DOB di Indonesia selama era reformasi dan bagaimana dampaknya terhadap keuangan negara. Kajian ini bersifat kajian kebijakan (policy research) dengan menghimpun data kemudian di analisis menjadi sebuah kesimpulan dan rekomendasi. Jenis kajian ini adalah studi literatur dengan metode yang digunakan adalah metode deskriptif kualitatif. Hasil kajian menunjukkan bahwa sejak era reformasi, pembentukan daerah otonomi baru sangat masif terjadi. Jika dihitung rata-rata dari 1999-2014, setiap tahun DOB provinsi dan kabupaten/kota bertambah sebanyak 13 DOB per tahun. Pembentukan DOB membutuhkan persiapan dan biaya yang cukup besar, mulai dari pembentukan awal hingga penyelenggaraannya. Selain itu, secara umum DOB menunjukkan dependensi fiskal yang lebih tinggi dibandingkan daerah lama. Dengan demikian, dapat dinyatakan bahwa pemebentukan DOB tersebut telah menimbulkan tekanan terhadap keuangan negara (APBN) akibat besarnya jumlah dana yang harus ditransfer kepada daerah-daerah baru.
Disfunción autonómica en la enfermedad de Parkinson: enfoque práctico
Authors: Rueda-Acevedo Mauricio , Castro Fuquen Francy
Published: August 2019

Los síntomas por disfunción autonómica son comunes en la enfermedad de Parkinson y están presentes en todas las fases de la enfermedad. Cubren una amplia variedad de síntomas, como manifestaciones gastrointestinales, urinarias, disfunción eréctil e hipotensión ortostática, entre otros, lo que genera discapacidad y deterioro en la calidad de vida. Afortunadamente, con intervenciones no farmacológicas y farmacológicas estos síntomas pueden mejorar sustancialmente, por lo que su evaluación resulta vital para el bienestar del paciente.
Los fashion films como contenido particular del marketing de moda: un análisis de su naturaleza en el contexto de los mensajes híbridos
Authors: Kam Leslie , Robledo-Dioses Kelly , Atarama-Rojas Tomás
Published: August 2019

Las marcas deben aportar contenidos de valor que puedan atraer la atención de sus públicos para generar resultados positivos con respecto a sus objetivos de comunicación. Esto es mucho más relevante en el sector de la moda, en donde la construcción de valor simbólico –más que la exclusividad del producto– es imprescindible para relacionarse emocionalmente con un consumidor de carácter aspiracional. En la actualidad, la publicidad tradicional, paradigma del modelo push, deja de ser eficiente para alcanzar a los públicos. Ante esto, han tomado especial relevancia los mensajes híbridos y, en particular, el fashion film como un tipo de contenido audiovisual propio del marketing de moda. En esta investigación partimos de una revisión bibliográfica exhaustiva de, por un lado, product placement como un tipo de publicidad y, por otro lado, de content marketing, advertainment y branded entertainment como tipos de branded content para identificar los conceptos que se aproximan a los fashion films. Así, tras un análisis de los diferentes mensajes híbridos que podrían acoger la categoría del fashion film, resaltan características que llevan a la conclusión de que el objeto de estudio responde no solamente al advertainment, sino también al branded entertainment, aunque, debido a las particularidades del sector de la moda, en este último es necesario admitir la presencia irreparable de los productos en la historia, siempre y cuando estos no formen parte de la narrativa al ser expuestos de manera protagónica, sino que se establezcan como objetos de embellecimiento de los personajes.
Drug Trafficking and Youth Mortality in Brazil: An Expression of Human Rights’ Violations
Authors: Motta Costa Ana Paula , Rudnicki Dani , Maia Goldani Julia
Published: August 2019

This paper aims to analyze the intersectional problematic that surrounds the vio-lations of adolescents’ human rights that happen in Brazil nowadays. It focuses, more specifically, on the involvement of these youths with drug trafficking, and on the relations between their participation in crime and the rising mortality rates amidst young age groups. A large part of Brazil’s children and teenagers grow up in contexts of social vulnerability, lack of opportunities, difficult access to economical assets, and personal devaluation. This situation often pushes young individuals into involvement with drug trafficking or armed robbery, since crime represents, in their context, a possibility for economic and social ascendance. In parallel, the criminal policy adopted by the Brazilian State, synthesized in the expression “war on drugs” and manifested in the promulgation of Law 11.343/06, focuses on repressive police actions, and favors imprisonment, while doing nothing to attack the social causes of the problem. The result is the mass incarceration of young and economically disfavored individuals as well as, not infrequently, their deaths during police approaches, characterizing a situation where these adoles-cents are both perpetuators and victims of violence.
Racionalidad y discernimiento: un debate filosófico-jurídico sobre la alteración de criterios para la definición de la capacidad civil
Authors: Cachapuz María Claudia
Published: August 2019

A partir del análisis de las distintas corrientes filosóficas, este texto discute el concepto de autonomía en el caso de conflictos jurídicos complejos, como en la definición de la capacidad civil, por la reciente entrada en vigor de la Ley no. 13.146/15 (Estatuto de la persona con deficiencia) en el ordenamiento jurídico brasileño. Se debate sobre la medida del establecimiento de límites apriorísticos a un ejercicio de libertad intersubjetiva y sobre cómo deben ofrecerse razones suficientes a la restricción de toda y cualquier libertad. Al mismo tiempo, hay la preocupación por tornar potente la autonomía de la persona, como un principio relevante para la construcción de la moral en la sociedad contemporánea. Esto permite el cuestionamiento a la aprobación reciente del Estatuto de la persona con deficiencia en Brasil, por suprimir los incisos del artículo 3º del Código Civil brasileño, extirpando, normativamente, el criterio del discernimiento para la eterminación
de la capacidad civil. Teniendo por base el discurso jurídico, se apunta como fundamental, para fines de interpretación, el rescate del concepto de discernimiento para la promoción del libre desarrollo de la personalidad humana.
Justicia transicional y los límites de lo (posible) punible. Reflexiones sobre la legitimidad del proceso de paz en Colombia
Authors: Nash Rojas Claudio
Published: August 2019

Este estudio propone que el proceso de paz colombiano ha ratificado que la jus-ticia de transición encuentra límites en los derechos humanos en relación con tres aspectos: a) no son posibles las medidas de amnistía o indulto para viola-ciones graves de los derechos humanos; b) las medidas de impunidad solo son posibles si se cumplió con el deber de reparar a las víctimas; y c) las medidas penales que implican un tratamiento diferente de quienes incurrieron en viola-ciones de derechos humanos en el contexto del conflicto armado son posibles si el Estado proporciona ciertos derechos mínimos con respecto a la repara-ción de las víctimas. El Acuerdo de Paz del 2016 y la jurisprudencia del Tribunal Constitucional difieren de las normas elaboradas por la Corte Interamericana de Derechos Humanos sobre el deber de investigar y sancionar las violaciones de los derechos humanos.
Participación de la mujer en los Programas de Desarrollo con Enfoque Territorial: una mirada con enfoque de género
Authors: Villa Mesa Juan Diego , Reyes Manrique Angélica María del Pilar
Published: August 2019

El presente artículo pretende analizar desde una perspectiva de género, la participación de la mujer en los Programas de Desarrollo con Enfoque Territorial (PDET) gestados en el Decreto 893 de 2017 y derivados del punto uno del Acuerdo final para la terminación del conflicto y la construcción de una paz estable y duradera, el cual contiene los lineamientos de la Reforma Rural Integral. Se analizan las estrategias de implementación del mencionado decreto para determinar si se garantiza y permite a las mujeres participar activamente y de forma diferenciada, en la transformación del territorio rural durante el posacuerdo, y si dicha participación constituye una acción afirmativa eficaz en la búsqueda por la equidad de género y la reivindicación histórica de los derechos de las mujeres. Se adopta como guía la metodología para el análisis de género en el fenómeno legal propuesto por Alda Facio, para determinar la presencia material del enfoque de equidad de género para las mujeres. En este análisis se abordan conceptos básicos sobre género y acciones afirmativas y su presencia en el Decreto 893 de 2017 para contextualizar así la actual situación de inequidad que viven las mujeres rurales en Colombia y el papel que se les asigna en la Reforma Rural Integral.
A propósito de los dos años de la firma del acuerdo de paz celebrado entre el Estado colombiano y la guerrilla de las FARC-EP
Authors: Mendieta González David
Published: August 2019

El pasado 24 de noviembre se cumplieron dos años de la firma del Acuerdo de Paz entre el Estado colombiano y la guerrilla de las FARC - EP. Durante este tiempo muchas cosas han pasado. El Congreso de la República y el Gobierno Nacional fueron facultados durante seis meses que se prorrogaron por otros seis meses, para implementar el acuerdo mediante normas jurídicas que tuvieron un trámite y control de constitucionalidad especial y abreviado, denominado fast track (Acto Legislativo 01 de 2016 y Sentencia C 699 de 2016).
Marco de referencia para reflexionar sobre la implementación del Acuerdo de Paz, desde el enfoque de equidad de género
Authors: Cardona Zuleta Elvigia
Published: August 2019

El presente artículo presenta el marco de referencia para reflexionar sobre el estado de la implementación del Acuerdo final para la terminación del conflicto y la construcción de una paz estable y duradera (Acuerdo de Paz) firmado por el Gobierno Colombiano y las FARC-EP en octubre del 2016, en lo que respecta a la inclusión del enfoque de género, en el entendido de que las partes en este conflicto incluyen a la sociedad colombiana en su conjunto, y de que como ciudadanos es nuestro deber velar para que, tanto en la producción normativa como en la interpretación se tenga presente el enfoque de género; esto supondría una conquista en términos de la promoción de los derechos de las mujeres, niñas y grupos LGBTIQ y en especial del derecho a una vida libre de violencias.
El control de convencionalidad y la prohibición de la discriminación en Chile
Authors: Aguilar Cavallo Gonzalo
Published: August 2019

En este trabajo se examinan casos de discriminación para determinar si la Corte Suprema chilena realiza un control de convencionalidad en la materia. La hipótesis que se propone es que la prohibición de la discriminación ha sido un terreno fértil, aunque excepcional, en el que la Corte Suprema ha realizado un control de convencionalidad. Se examina cómo y en qué medida el máximo tribunal del poder judicial lleva a cabo este tipo de control. La Corte Suprema utiliza las convenciones internacionales, el soft law y las opiniones de los órganos de tratados para mejorar la protección contra la discriminación.
TEATRO DRAMÁTICO E PERFORMATIVO: ENTRE O REAL E O FICCIONAL
Authors: Furtado Daniel
Published: August 2019

O artigo discute alguns aspectos da relação entre o real e o ficcional observadas no Teatro Dramático e no Teatro Performativo, assim como o caráter de não-representação e de evento que norteiam a ação do ator no teatro performativo.
CULTURA JUVENIL EM CENA: VIOLÊNCIA E DIVERSIDADE
Authors: Wendell Ney
Published: August 2019

O corpo cênico do jovem e sua manifestação em cena são abordados a partir do estudo da produção e recepção do espetáculo teatral Cuida Bem de Mim. Este estudo faz parte da dissertação intitulada “Teatro, Afeto e Cultura Juvenil: recepção do espetáculo Cuida Bem de Mim”, desenvolvida no PPGAC-UFBA. Foi feito um estudo da recepção do espetáculo Cuida Bem de Mim junto a 2.500 jovens de 14 escolas públicas que assistiram e participaram do debate no período de 2005 a 2007 nas cidades de Salvador, Rio de Janeiro e Recife. É uma peça que trata da violência nas escolas públicas e da reconstrução das relações afetivas no ambiente escolar. O jovem na sua corporeidade híbrida foi observado a partir desta encenação, que trouxe para a cena a violência física e simbólica e a diversidade da cultura juvenil através de elementos da multiplicidade, mutação e desequilíbrio na interpretação dos personagens. Com isso, chegaram-se as categorias analíticas que cruzam estas temáticas a partir de eixos estéticos como destruição, explosão, embate e negritude em cena.
À BEIRA DAS IMAGENS: O CÉREBRO COMO TELA DE PROJEÇÃO
Authors: Com Romeo Castellucci; Trad. Marta Isaacsson Enrico Pitozzi
Published: August 2019

Entrevista gentilmente cedida por Romeo Castellucci, com o consentimento do entrevistado, por Enrico Pitozzi à Revista Cena. Tem-se aqui o privilégio de descortinar os fatores envolvidos no processo de criação de um dos renomados encenadores contemporâneos.
O MOVIMENTO COMO MODO DE CRIAÇÃO: A EXPERIÊNCIA DO VIVO
Authors: Dal Forno Adriana
Published: August 2019

Este estudo observa aspectos do sistema proposto por Konstantin Stanislávski referentes aos processos de vivência corporificada das ações físicas. Os elementos do sistema atenção, tempo-ritmo, imaginação e plasticidade dos movimentos são apresentados como operadores dos impulsos que efetivam o movimento em ato, e este como produto e produção de vivência, a experiência do vivo. Nesse sentido, os movimentos são portadores de intensidade e de tendências para a tessitura do acontecimento cênico.
O TEATRO NA EDUCAÇÃO DOS PROFESSORES DOS ANOS INICIAIS DO ENSINO FUNDAMENTAL: POSSIBILIDADES DE UMA FORMAÇÃO INTEGRAL
Authors: Werlang Cristiane
Published: August 2019

Orientador: Dr. João Pedro Alcântara Gil (PPGAC/UFRGS) Este artigo discorre sobre a importância do teatro na formação do educador dos anos iniciais do ensino fundamental. Através do ato relacional do jogo e/ou da brincadeira desencadeiam-se aprendizagens fundamentais na formação do ser humano. Em que medida o teatro com seus jogos dramáticos e brincadeiras cantadas, podem mediar a construção de uma docência mais dialógica, humana e contextualizadora?
CACNB2 Is a Novel Susceptibility Gene for Diabetic Retinopathy in Type 1 Diabetes
Authors: Vuori Nadja , Sandholm Niina , Kumar Anmol , Hietala Kustaa , Syreeni Anna , Forsblom Carol , Juuti-Uusitalo Kati , Skottman Heli , Imamura Minako , Maeda Shiro , Summanen Paula A. , Lehto Markku , Groop Per-Henrik
Published: August 2019

Diabetic retinopathy is a common diabetes complication that threatens the eyesight and may eventually lead to acquired visual impairment or blindness. While a substantial heritability has been reported for proliferative diabetic retinopathy (PDR), only a few genetic risk factors have been identified. Using genome-wide sib pair linkage analysis including 361 individuals with type 1 diabetes, we found suggestive evidence of linkage with PDR at chromosome 10p12 overlapping the CACNB2 gene (logarithm of odds = 2.73). Evidence of association between variants in CACNB2 and PDR was also found in association analysis of 4,005 individuals with type 1 diabetes with an odds ratio of 0.83 and P value of 8.6 × 10−4 for rs11014284. Sequencing of CACNB2 revealed two coding variants, R476C/rs202152674 and S502L/rs137886839. CACNB2 is abundantly expressed in retinal cells and encodes the β2 subunit of the L-type calcium channel. Blocking vascular endothelial growth factor (VEGF) by intravitreous anti-VEGF injections is a promising clinical therapy to treat PDR. Our data show that L-type calcium channels regulate VEGF expression and secretion from retinal pigment epithelial cells (ARPE19) and support the role of CACNB2 via regulation of VEGF in the pathogenesis of PDR. However, further genetic and functional studies are necessary to consolidate the findings.
Cutaneous Epithelial to Mesenchymal Transition Activator ZEB1 Regulates Wound Angiogenesis and Closure in a Glycemic Status–Dependent Manner
Authors: Singh Kanhaiya , Sinha Mithun , Pal Durba , Tabasum Saba , Gnyawali Surya C. , Khona Dolly , Sarkar Subendu , Mohanty Sujit K. , Soto-Gonzalez Fidel , Khanna Savita , Roy Sashwati , Sen Chandan K.
Published: August 2019

Epithelial to mesenchymal transition (EMT) and wound vascularization are two critical interrelated processes that enable cutaneous wound healing. Zinc finger E-box binding homeobox 1 (ZEB1), primarily studied in the context of tumor biology, is a potent EMT activator. ZEB1 is also known to contribute to endothelial cell survival as well as stimulate tumor angiogenesis. The role of ZEB1 in cutaneous wounds was assessed using Zeb1+/− mice, as Zeb1−/− mice are not viable. Quantitative stable isotope labeling by amino acids in cell culture (SILAC) proteomics was used to elucidate the effect of elevated ZEB1, as noted during hyperglycemia. Under different glycemic conditions, ZEB1 binding to E-cadherin promoter was investigated using chromatin immunoprecipitation. Cutaneous wounding resulted in loss of epithelial marker E-cadherin with concomitant gain of ZEB1. The dominant proteins downregulated after ZEB1 overexpression functionally represented adherens junction pathway. Zeb1+/− mice exhibited compromised wound closure complicated by defective EMT and poor wound angiogenesis. Under hyperglycemic conditions, ZEB1 lost its ability to bind E-cadherin promoter. Keratinocyte E-cadherin, thus upregulated, resisted EMT required for wound healing. Diabetic wound healing was improved in ZEB+/− as well as in db/db mice subjected to ZEB1 knockdown. This work recognizes ZEB1 as a key regulator of cutaneous wound healing that is of particular relevance to diabetic wound complication.
White Matter Microstructural Change Contributes to Worse Cognitive Function in Patients With Type 2 Diabetes
Authors: Gao Shudan , Chen Yaojing , Sang Feng , Yang Yiru , Xia Jianan , Li Xin , Zhang Junying , Chen Kewei , Zhang Zhanjun
Published: August 2019

Patients with type 2 diabetes mellitus (T2DM) have a considerably high risk of developing dementia, especially for those with mild cognitive impairment (MCI). The investigation of the microstructural change of white matter (WM) between T2DM with amnesic MCI (T2DM-aMCI) and T2DM with normal cognition (T2DM-NC) and their relationships to cognitive performances can help to understand the brain variations in T2DM-related amnesic cognitive impairment. In the current study, 36 T2DM-aMCI patients, 40 T2DM-NC patients, and 40 healthy control (HC) individuals underwent diffusion tensor image and T1-weighted MRI scans and comprehensive cognition assessments. All of these cognitive functions exhibited intergroup ranking differences in patients. The T2DM-NC patients and HC individuals did not reveal any significant differences in WM integrity. The T2DM-aMCI patients showed disrupted integrity in multiple WM tracts compared with HC and T2DM-NC. Specifically, the damaged WM integrity of the right inferior fronto-occipital fasciculus and the right inferior longitudinal fasciculus exhibited significant correlations with episodic memory and attention function impairment in T2DM patients. Furthermore, cognitive impairment-related WM microstructural damage was associated with the degeneration of cortex connected to the affected WM tract. These findings indicate that degeneration exists extensively in WM tracts in T2DM-aMCI, whereas no brain WM damage is evident in T2DM-NC.
LE DELICE CAFÉ AND BAKERY STORE ATMOSPHERE AND PROMOTION ON CONSUMER SATISFACTION AND LOYALTY
Authors: Suryana Popo , Haryadi Mochammad Rifal
Published: August 2019

Le Delice Cafe and Bakery is a business that engaged in the culinary business. Analysis of data used is using path analysis (path analysis), multiple correlation, and coefficients of determination. Based on the analysis of the effect of the store atmosphere and promotion to customer satisfaction simultaneously is equal 159.147. While partially in the structure of I store atmosphere into a variable that has a dominant influence on customer satisfaction, because based on the calculation of standardized coefficients beta has the highest value of 0.519 compared to the promotion. While in structure II promotion become variable which have dominant influence to consumer loyalty, because based on calculation of standardized coefficients beta have highest value that is equal to 0.509 compare to store atmosphere and consumer satisfaction.