bluuebunny/crossref_metadata_2025 huggingface dataset:
Ruta de la Integración Latinoamericana: un reflejo del patrimonio cultural de Mato Grosso do Sul
Authors: Lima Joana Ribas Bernardes , Lima Maria Margareth Escobar Ribas , Souza Rodrigo Mendes de , Junqueira Juliana Villela
Published: April 2024

Basado en la propuesta del Dossier: El Papel de Unirila en los Desafíos de la Integración en la Ruta Biooceánica (Brasil, Paraguay, Argentina y Chile), este artículo tiene como objetivo conceptualizar, identificar y analizar la importancia del Patrimonio Cultural de Mato Grosso do Sul-MS y su relevancia en el contexto de la ruta biooceánica, ya que este corredor vial atraviesa parte de este territorio, causando impacto socioeconómico y cultural. El corredor biooceánico es un proyecto iniciado en el año 2000 con el propósito de construir una red de obras de infraestructura como hidrovías, puertos, interconexiones de energía y comunicaciones y corredores viales para conectar el Puerto de Santos, en Brasil, con puertos chilenos, pasando por Paraguay y Argentina. Este evento sin duda abrirá posibilidades económicas en varios aspectos de la región y, considerando e identificando la cultura local puede agregar valor e incorporar el tema cultural en acciones turísticas, desarrollo local y políticas públicas. Este trabajo presenta una metodología a través de la investigación documental y bibliográfica y busca información sobre el patrimonio cultural de Mato Grosso do Sul-MS, junto con los organismos competentes en la identificación y preservación de la cultura de la EM. Con esto, se espera que este artículo contribuya con información para estas acciones de desarrollo y para aumentar la autoestima de la comunidad que pertenece a este lugar.
Mobilidade sustentável e o papel das cidades na integração territorial pelo corredor de desenvolvimento
Authors: Bertuzzi Felipe Buller , Bourlegat Cleonice Alexandre Le , Casadei Juliana de Mendonça
Published: April 2024

O objetivo deste estudo foi apresentar e discutir estratégias de mobilidade sustentável e o papel das cidades na integração territorial, num corredor de desenvolvimento de natureza transnacional. Trata-se de um estudo de natureza exploratória e explicativa em consonância ao objetivo estabelecido, baseado em fontes bibliográficas e documentais, com o propósito de refletir sobre as propostas da Rota de Integração Latino-Americana (RILA) como corredor de desenvolvimento. De acordo com a pesquisa, pôde-se verificar o importante papel exercido pela mobilidade sustentável no corredor de transporte, como motor de desenvolvimento, assim como o papel estratégico de nó multimodal exercido pela cidade numa rede urbana polinuclear, especialmente quando esta adota medidas de mobilidade urbana sustentável. A mobilidade sustentável refletida neste estudo abrange as dimensões econômica, social e ambiental. Procurou-se alertar sobre a importância atual de um maior esforço no sentido do uso de tecnologias digitais, detectar soluções energéticas de descarbonização no transporte e buscar conexões com outros corredores de transporte, em especial, ferroviário, para um efeito estruturante da integração territorial pretendida, para se atingir desde a escala regional até a transnacional.
Recalibration and Recommendation for the Prediction of the California Bearing Ratio (CBR) from Dynamic Cone Penetrometer (DCP)
Authors: Chokkerd Jirawat , Udomchai Artit , Sultornsanee Sivarit , Kaewhanam Nopanom
Published: April 2024

The high reliable correlations between CBR and DCP in general proposed are presented in this paper. We analyzed the test data and correlations from many researchers to find the best equation for prediction the CBR from DCP test. The findings show that all correlations from existing paper are based on local material and cannot apply to soil in a different location in general purpose. New correlations between CBR and DCP were proposed and validated in this paper for general uses. The validation confirmed that these new correlations can predict well with higher R2.
Cultural Routes as Cultural Tourism Products for Heritage Conservation and Regional development: A Systematic Review
Authors: Lin Xinyue , Shen Zhenjiang , Teng Xiao , Mao Qizhi
Published: April 2024

Cultural routes are a composite set of heritage, referring to any ancient routes of human communication. As one of the key products of cultural tourism, they providing visitors with a rich cultural experience across regions. We systematically review reports and studies related to the tourism development of 38 cultural routes cases around the world, with a special focus on their distribution, typology, planning patterns and tools for cultural tourism. We summarized eight tools, there are some differences in how often these eight tools are used by the different types of routes and different planning patterns for routes tourism. The study also made an evaluation system based on the conservation principles of cultural routes to find out how different tools of tourism affect the conservation and development of the historical region. It was found that although many efforts have been made by tourism decision-makers to protect and develop cultural routes there are still many problems and challenges in the process of tourism development along cultural routes. We close the paper by making a few recommendations for decision makers and researchers concerning future routes’ tourism planning and study.
Solving the Hubble Tension Using the Union2 Supernova Database
Authors: Haug Espen , Tatum Eugene
Published: April 2024

We demonstrate how a rigorous mathematical approach can be used to extract a current CMB temperature of 2.7276 ±0.0723 K from the 580 type Ia supernova data points in the Union2 database. Using redshift formula: z = Sqrt(Rh/R_t) − 1, incorporated into our new CMB redshift prediction redshift formula, we find that the above current CMB temperature value is a remarkably good match for this particular data set. In addition, we can alternatively start out with the measured current CMB temperature and extract the Hubble constant from all 580 supernovae. We then get an estimated Hubble constant of H0 = 66.8711+0.0019 km/s/Mpc when using the CMB temperature from the recent Dhal et al study [1] in combination with redshifts from all 580 supernovae. Furthermore, we get an estimated Hubble constant value of H_0 = 66.8943+0.0287 km/s/Mpc when using the CMB temperature measured by Fixsen [2]. In summary, our simple model essentially perfectly matches all 580 type Ia supernova redshifts while extracting H_0 or T_0 values. The Hubble constant we extract by this method fits very well with the Hubble constant extracted from the CMB by other studies. We believe that our new approach likely solves the Hubble tension problem, at least inside R_h = ct cosmology.
Secrecy Analysis of a Mu-MIMO LIS-Aided Communication Systems Under Nakagami-M Fading Channels
Authors: Ferreira Ricardo Coelho , Fraidenraich Gustavo , de Figueiredo Felipe A. P. , de Lima Eduardo Rodrigues
Published: April 2024

This study delves into the performance evaluation of an avant-garde technology in mobile communications known as Large Intelligent Surface (LIS), poised to be an integral component of the sixth-generation (6G) networks. This groundbreaking technology has the potential to markedly augment the Signal-to-Interference plus Noise Ratio (SINR) by orchestrating signals originating from the base station through a network of digitally controlled reflectors meticulously engineered to modulate the phase of incoming electromagnetic waves. A LIS can establish a Line of Sight (LoS) within channels that inherently do not have a LoS. In addition, it can also be optimized to increase transmission security by ensuring that the signal reaches only the target users of the message with better quality. In this study, analytical expressions were derived to calculate the distribution parameters, the bit error probability, and the secrecy outage probability. These calculations consider the presence of an eavesdropper link, highlighting the potential of the LIS to increase the confidentiality of digital communication systems. The accuracy of the proposed formulas was demonstrated by showing how the performance of the LIS varies with different design parameters and environmental fading.
Twenty-Year Climatology of Solar UV and PAR in Cyprus: Integrating Satellite Earth Observations with Radiative Transfer Modeling
Authors: Fragkos Konstantinos , Fountoulakis Ilias , Charalampous Georgia , Papachristopoulou Kyriakoula , Nisantzi Argyro , Hadjimitsis Diofantos Gl. , Kazadzis Stelios
Published: April 2024

In this study, we present comprehensive climatologies of effective ultraviolet (UV) quantities and photosynthetically active radiation (PAR) over Cyprus for the period 2004 to 2023, leveraging the synergy of earth observation (EO) data and radiative transfer model simulations. The EO dataset, encompassing satellite and re-analysis data for aerosols, total ozone column, and water vapor, alongside cloud modification factors, to capture the nuanced dynamics of Cyprus's atmospheric conditions. With a temporal resolution of 15 minutes and a spatial of 0.05°x0.05°, these climatologies undergo rigorous validation against established satellite datasets and are further evaluated through comparisons with ground-based global horizontal irradiance measurements provided by the Meteorological Office of Cyprus. This dual-method validation approach not only underscores the models' accuracy but also highlights their proficiency in capturing intra-daily cloud coverage variations. Our analysis extends to investigating the long-term trends of these solar radiation quantities, examining their interplay with changes in cloud attenuation, aerosol optical depth (AOD), and total ozone column (TOC). Significant decreasing trends in the noon ultraviolet index (UVI), of -2 to -4% per decade have been found in Autumn, especially marked on the island’s Northeastern part, mainly originating from the (significant) positive trends in TOC. The significant decreasing trends in TOC, of -2 to -3% per decade that were found in Spring do not result in correspondingly significant positive trends in the noon UVI since variations in cloudiness and aerosols also have a strong impact on the UVI in this season. The seasonal trends in the Daylight Integral (DLI) were generally not significant. These insights provide a valuable foundation for further studies aimed at developing public health strategies and enhancing agricultural productivity, highlighting the critical importance of accurate and high-resolution climatological data.
CRISPR/Cas Mediated Genome Engineering in Plants: Application and Future Prospective
Authors: Mishra Swetaleena , Nayak Subhendu , Tuteja Narendra , Poosapati Sowmya , Swain Durga Madhab , Sahoo Rajan Kumar
Published: April 2024

Genetic engineering in the field for designing crop improvement has become an essential element in responding to the increasing need for food safety, environmental sustainability, and climate-resilient crops. The latest molecular technology is used by many breeders today to achieve remarkable results. Fast genome editing is currently being seen in a variety of organisms, including plants, because to the high specificity, high effectiveness, and low production cost of CRISPR/Cas [Clustered regulatory interspaced short palindromic repeat (CRISPR)-associated protein (Cas)] technology. Its applications in developing higher-yielding, nutrition rich, disease resistance, stress-tolerant crops fruits, and vegetables. Therefore, this technology has the potential to revolutionize agriculture and contribute to global food security. The Cas protein provides the enzymatic machinery necessary for the acquisition of new cells that target invasion elements. Cas proteins such as Cas9, Cas12, Cas13, and Cas14, among others, have distinct architectures and have been used to create new genetic tools that improve features that are important for agriculture. The versatility of Cas has accelerated genomic analysis and facilitated the use of CRISPR/Cas to manipulate and alter nucleic acid sequences in cells of different organisms. This review provides the evolution of CRISPR technology exploring its mechanisms and contrasting it with traditional breeding and transgenic approaches to improve different stress tolerance. We will also discuss the CRISPR/Cas system and explore the workings of the three Cas proteins that are currently known to exist: Cas12, Cas13, and Cas14. The edited crops by this technology do not have foreign DNA inserted into their genome, therefore, they are considered as non-transgenic by the regulatory bodies in most countries.
Relationship of Body Condition Score, Body Parameters and Body Carcass Fat in Coopworth Breeding Ewes
Authors: Shalaldeh Ahmad , Page Shannon , Anthony Patricia , Charters Stuart , Safa Majeed , Logan Chris , Johnson Rebecca
Published: April 2024

The objective of this study is to determine the relationship between body condition score (BCS) and body carcass fat (BCF) of ewes at two key stages of the production cycle. Data were collected from 88 Coopworth ewes including BCS measurements manually evaluated by the farm manager, BCF measurements determined by computerized tomography (CT) and body parameter measurements automatically determined by an image processing application. Artificial neural network (ANN) statistical analysis method was used to develop a relationship between the body parameters and the BCF with an r2=0.96 and RMSE=1.01 using all top and side variables.
Exploring Evolution and Trends: A Bibliometric Analysis and Scientific Mapping of Multiobjective Optimization Applied to Hybrid Microgrid Systems
Authors: Tahir Kawakib Arar , Ordóñez Javier , Nieto Juanjo
Published: April 2024

Hybrid Renewable Energy Systems (HRES) integrate renewable sources, storage, and optionally conventional energies, offering an eco-friendly solution to fossil fuels. Microgrids (MGs) bolster HRES integration, enhancing energy management, resilience, and reliability at various levels. This study, emphasizing the need for refined optimization methods, investigates three themes: renewable energy, microgrid, and multiobjective optimization (MOO), through a bibliometric analysis of 470 Scopus documents from 2010-2023, analyzed with SciMAT software. It segments the research into two periods, 2010-2019 and 2020-2023, revealing a surge in MOO focus, especially in the latter period, with a 35% increase in MOO-related research. This indicates a shift towards com-prehensive energy ecosystem management that balances environmental, technical, and economic elements. The initial focus on MOO, genetic algorithms, and energy management systems has expanded to include smart grids and electric power systems, with MOO remaining a primary theme in the second period. The increased application of Artificial Intelligence (AI) in optimizing HMGS within the MOO framework signals a move towards more sustainable, intelligent energy solutions. Despite progress, challenges remain, including high battery costs, the need for reliable MOO data, the intermittency of renewable energy sources, and HMGS network scalability issues, highlighting directions for future research.
MS785-MS27, a Commercially Available Antibody Cocktail against Misfolded SOD1, Recognizes Various Conformation-disordered SOD1 Species Lacking the Incorporated Zn ion
Authors: Tokuda Eiichi , Sakashita Yume , Tokoro Naoya , Date Ayano , Kosuge Yasuhiro , Miyasaka Tomohiro
Published: April 2024

Misfolding of superoxide dismutase-1 (SOD1) is a pathological hallmark of amyotrophic lateral sclerosis (ALS) with SOD1 mutations. The development of antibodies specific for misfolded SOD1 deepens our understanding of how the protein participates in ALS pathogenesis. Since the term “misfolding” refers to various disordered conformers other than the natively folded one, which misfolded species are recognized by specific antibodies should be determined. Here, we molecularly characterized the recognition by MS785-MS27, an antibody cocktail experimentally confirmed to recognize over 100 ALS-linked SOD1 mutants. Indirect ELISA revealed that the antibody cocktail recognized Zn-deficient wild-type and mutated SOD1 species. It also recognized conformation-disordered wild-type and mutated SOD1 species, such as unfolded and oligomeric forms, but had less affinity for the aggregated form. Antibody-reactive SOD1 exhibited cytotoxicity to a motor neuron cell model, which was blocked by Zn treatment with Zn-deficient SOD1. Immunohistochemistry revealed antibody-reactive SOD1 mainly in spinal motor neurons of SOD1G93A mice throughout the disease course, and the distribution after symptomatic stages differed from that of other misfolded SOD1 species. This suggested that misfolded SOD1 species exist as heterogeneous populations. In conclusion, MS785-MS27 recognizes various misfolded SOD1 lacking the incorporated Zn ion and should be useful for monitoring Zn availability in SOD1.
A Color-Detectable Vitamin C Controlled-Release System Fabricated Using Electrospinning
Authors: Shin Min Jae
Published: April 2024

This study develops a vitamin C controlled-release system trackable via color changes as a function of vitamin C release. The system is composed of coaxial microfibers prepared via coaxial electrospinning, with a core of poly(ethylene oxide) (PEO) incorporating vitamin C, and a shell composed of polycaprolactone (PCL) containing polydiacetylene (PDA) as the color-changing material. The shell thickness was controlled by adjusting the amount of PCL ejected during electrospinning, allowing the regulation of the release rate of vitamin C. When vitamin C added to PEO penetrated the PCL layer, the color of PDA changed from blue to red, indicating a color change. The results of this study can be applied to devices that require immediate detection of vitamin C release levels.
The Kerch Peninsula in Transition: A Comprehensive Analysis of Land Use and Land Cover Changes Over Thirty Years
Authors: Krivoguz Denis
Published: April 2024

This study presents an in-depth analysis of land use and land cover change on the Kerch Peninsula over a period spanning three decades. Utilizing convolutional neural networks alongside satellite imagery analysis, we have mapped and quantified the changes in land use and cover, revealing significant trends and transformations within the peninsula's landscape. The research aims to elucidate the interplay between anthropogenic activities, climatic variations, and policy interventions in shaping land cover dynamics, thereby providing insights into the environmental and socio-economic impacts of these changes. Our findings indicate a marked increase in urban expansion at the expense of natural ecosystems, including forests and wetlands, underscoring the urgent need for sustainable land management strategies. The study highlights the role of agricultural intensification and expansion in altering the peninsula's ecological balance and emphasizes the critical importance of integrating change analysis and prediction. By leveraging advanced remote sensing and GIS technologies, our analysis not only enhances the understanding of the complex dynamics driving land use and land cover change but also showcases the potential of predictive modeling in forecasting future land cover scenarios. The implications of this study extend beyond the Kerch Peninsula, offering valuable lessons for managing land use changes and conserving natural landscapes in similar regions globally.
Identification of Convection as a Source for the Gravity Waves Observed in the Upper Mesosphere during Indo-French Campaign on Coupling of Lower and Middle Atmospheres
Authors: Pramitha M. , Venkat Ratnam M. , Taori Alok
Published: April 2024

An Indo-French campaign was conducted during May 2014 at Gadanki (13.5oN, 79.2oE), India, for investigating gravity wave (GW) coupling between the lower and middle atmospheres using a suite of experimental techniques. In this paper we are presenting the sources for those GWs which are observed at airglow layer (~87 km) using (OH) Airglow Imager during the campaign. For this purpose we have developed a background model atmosphere by combining the ERA-Interim, MSIS E 90 model and HWM 07 model data sets. Uniqueness of the present study lies in using near-real time background atmosphere data from simultaneous radiosonde and SVU Meteor Radar covering both source and propagation/ dissipation regions of GWs. We have observed 17 wave events and used GROGRAT model for reverse tracing to locate the source(s). When we searched for the sources near the terminal points or along the ray path, deep convection is found to occur but no strong wind shear. This indicates that the source for the observed GWs is deep convection. We have also simulated small scale waves that can reach mesosphere during different seasons (background conditions). GWs with periods less than 100 minutes and horizontal wavelengths less than 200 km are mostly reaching the mesospheric altitudes. Interestingly, it is found that only few GWs that are generated in the troposphere reach the mesospheric altitudes during the monsoon season, though strong sources like convection and wind shear persist throughout this season. Thus, background wind plays significant role in deciding the propagation of GWs in to upper atmosphere.
Sarc-Global: A New Sarcopenia Screening Tool in Older Adults
Authors: Lopes Natalia Correia , Vicedomini Ana Carolina Costa , Magalhães Natalia Vieira , Waitzberg Dan L. , Jacob-Filho Wilson , Busse Alexandre Leopold , Ferdinando Douglas , Pereira Rosa Maria Rodrigues , Torrinhas Raquel S. M. M. , Belarmino Giliane
Published: April 2024

Sarcopenia is associated with clinical complications, which increase mortality. Effective sarcopenia risk screening in the elderly should be grounded in a comprehensive assessment, encompassing both nutritional status and medication use. Current screening tools, while emphasizing muscular per-formance, exhibit limited sensitivity in identifying elderly individuals at risk of sarcopenia. This cross-sectional study aimed to develop a sarcopenia risk screening tool, named Sarc-Global, with enhanced sensitivity, incorporating factors pertinent to the overall health of the elderly. Utilizing the criteria established by EWGSOP2 for diagnosing sarcopenia, we evaluated 395 communi-ty-dwelling elderly individuals. This evaluation served as a reference for assessing the efficacy of two validated questionnaires, Sarc-F and Sarc-CalF, and our newly developed Sarc-Global. Con-structed through multiple logistic regression, Sarc-Global integrates variables such as sex, age, medication use, body mass index, arm circumference, and handgrip strength – all significantly associated with sarcopenia (p
Sensors and Strategy for Anticollision Function dedicated to Augmented Electric Wheelchair
Authors: Favey Clément , Farcy René , Bogaert Lucas , Berthe Issa , Jordan Liam
Published: April 2024

Today, there are commercially available high-performance electric wheelchairs, capa-ble of responding to strong limitations. However, despite these advancements, there is a significant portion of the population with severe disabilities who cannot access this mobility solution due to safety reasons. Indeed, either due to motor issues preventing reliable control of the wheelchair's commands, or associated visual or cognitive pathologies, the use of an electric wheelchair by these individuals would put them at risk and could also constitute a danger to those around them. This is why our research team is working on the development of augmented wheelchairs that allow a greater autonomy. We are mainly developing a system compatible with all electric wheel-chairs on the market, capable of making them anti-collision and anti-fall on uneven ground (sidewalks, stairs, etc.). In this article, we present our solution regarding the anti-collision function, in particular the sensors used to do this, as well as the strategy. We will focus on the shortcomings and weaknesses of various types of sensors and demonstrate how, by combining them in a certain way, we can develop a collision avoidance device capable of managing the diversity of everyday life situations. The two types of sensors that will be combined here are an in-house developed special near infrared sensor from the laboratory and a commercially available ultrasonic sensor. We will present the internal operation of the sensors, their limitations, experimental tests involving integration with the wheelchair, and the structure of the complete device.
Post-Conization HPV Vaccination and Its Impact on Viral Status: A Retrospective Cohort Study in Troms and Finnmark, 2022
Authors: Rykkelid Marie , Wennberg Helga Marie , Richardsen Elin , Sørbye Sveinung Wergeland
Published: April 2024

Human papillomavirus (HPV) is associated with cellular changes of the cervix leading to cancer, which highlights the importance of vaccination in preventing HPV infections and subsequent cellular changes. Women undergoing treatment (LEEP) for high-grade cervical intraepithelial neoplasia (CIN2+) remain at risk for recurrence. This study assesses the effect of post-conization HPV vaccination on the viral status of women six months post-conization, aiming to evaluate the vaccine's effectiveness in preventing recurrence of CIN2+. A retrospective cohort study was conducted among women in Troms and Finnmark who underwent conization in 2022. Using the SymPathy database and the national vaccination register (SYSVAK), we analyzed the vaccination status and HPV test results of women born before 1991, who had not received the HPV vaccine prior to conization. Out of 419 women undergoing conization, 243 met the inclusion criteria. A significant association was found between post-conization HPV vaccination and a negative HPV test at six months follow-up (ARR = 12.1%, P = 0.039). Post-conization HPV vaccination significantly reduced the risk of a positive HPV test at the first follow-up, suggesting its potential in preventing recurrence of high-grade cellular changes. The retrospective design and the insufficient control of confounding variables underscore the necessity for further studies to confirm these findings.
Upgrading/Deacidification of Organic Liquid Phase by Liquid-Liquid Extraction Using Methanol/Water as Solvent
Authors: Machado Nélio Teixeira , Mota Silvio Alex Pereira da , Leão Raquel Ana Capela , Souza Rodrigo O. M. A. , Duvoisin, Jr. Sergio , Borges Luiz Eduardo Pizarro , Mota and Andréia de Andrade Mâncio da
Published: April 2024

The objective of this work was to investigate the deacidification of bio-oils (BOs) from triglyceride-based biomass through the application of liquid-liquid extraction (LLE) in a simple stage, using methanol and water as a binary solvent and feed/solvent ratio of 1/1. For this, the effects of process parameters such as the water content present in the solvent, the content of carboxylic acids present in the bio-oil, and the extraction temperature on the deacidification process through the efficiency and distribution coefficient were evaluated, as well as the effects of such parameters on the quality of deacidified bio-oils through physical-chemical analyzes and GC-MS analysis. The results show that such process parameters significantly affect the quality of deacidified bio-oils. The ideal condition to have the highest acid removal, i.e., the highest deacidification efficiency (72.65%), is the one in which the deacidification process is performed with aqueous methanol (5% water) at 35 °C and for BOs that have a total acid number (TAN) equal to 24.38 mg KOH/g. Therefore, the process of deacidification by LLE using aqueous methanol is a promising alternative for removing carboxylic acids and other oxygenated compounds, contributing significantly to the upgrading or improving biofuels produced by catalytic thermal cracking.
Wastewater-Based Epidemiology for SARS-CoV-2 in Northern Italy: A Spatiotemporal Model
Authors: Fondriest Matilde , Vaccari Lorenzo , Aldrovandi Federico , De Lellis Laura , Ferretti Filippo , Fiorentino Carmine , Mari Erica , Mascolo Maria Grazia , Minelli Laura , Perlangeli Vincenza , Bortone Giuseppe , Pandolfi Paolo , Colacci Annamaria , Ranzi Andrea
Published: April 2024

The study investigated the application of Wastewater-Based Epidemiology (WBE) as a tool for monitoring SARS-CoV-2 prevalence in a city in Northern Italy from October 2021 to May 2023. Starting from a widely applied deterministic model, this study proposed a variation to take into account population characteristics and virus biodegradation in the sewer network. The model calculated virus loads and corresponding COVID-19 cases over time in different areas of the city and was validated with healthcare data while considering viral mutations, vaccinations, and testing variability. The correlation between the predicted and reported cases was high across the three waves that occurred in the considered period, demonstrating the model’s capacity to predict relevant fluctuations in the number of cases. Population characteristics did not substantially influence the predicted and reported infection rates. Conversely, biodegradation significantly reduced the virus load reaching the wastewater treatment plant, resulting in a 30% reduction in the total virus load produced in the study area. This approach can be applied for comparing virus load values across cities with varying population demographics and sewer network structures, enhancing the comparability of WBE data for effective surveillance and intervention strategies.
Restoring Severely Atrophic Edentulous Ridge of Mandible Using Self-Expanding Tissue Expander – A Case Report
Authors: Won Chiyun
Published: April 2024

Introduction

The placement of implants is often hindered by a severely atrophic mandibular edentulous ridge. A sufficient volume of bone graft is crucial for successful implant restoration. The required bone graft volume directly correlates with the deficiency present in the edentulous ridge. If the residual crestal bone height is so low that the distance between the crestal ridge and the inferior alveolar nerve is less than 2 mm, a significant bone augmentation procedure is necessary. This procedure must ensure the implants are surrounded by a sufficient margin of bone, aiming for a final height of more than 8 mm and a width of more than 7 mm. Achieving primary closure with adequate soft tissue is vital for the success of the bone graft procedure. The key to successful bone grafting lies in the effective management of the soft tissue covering.

Case Report

This case report details the treatment of a patient with severely atrophic edentulous ridges on both sides, addressed using Self Inflating Tissue Expanders (SITEs) to facilitate bone grafting and implant placement. Following soft tissue expansion, bone grafting and implant placement were successfully performed. The implants supported a fixed restoration, which remained stable and complication-free over a seven-year observation period.

Conclusion

The SITE (Self-Inflating Tissue Expander) proved effective in obtaining a substantial amount of bone graft needed for implant installation. A seven-year follow-up confirmed the implants were well-functioning with stable bone support, healthy soft tissue coverage, and adequate vestibular depth.
Adapting childhood obesity and comorbidities lifestyle interventions from perspective and experience of parents from Black, Asian and Minority Ethnicities in England
Authors: Alkhatib Ahmad , Obita George , Burns Mark , Nnyanzi Lawrence Achilles , Kuo Chia-Hua , Barengo Noel C
Published: April 2024

Preventing childhood obesity and associated comorbidities is often hampered by disproportionate disparity in healthcare provision in minority ethnic populations. This study contextualised lifestyle factors influencing childhood obesity and related comorbidity from the perspectives and experiences of parents of ethnic minority children with obesity comorbidity.
Families of Black, Asian and Minority Ethnicities (BAME) in the Northeast of England (n=180) were contacted, and families with a child diagnosed with obesity and comorbidity (non-alcoholic fatty liver disease, musculoskeletal problems, respiratory disorder, or polycystic ovarian disease) were interviewed (n=11). Semi-structured interviews and qualitative thematic analysis included parents’ perspective and experience on how their children were impacted by obesity and comorbidities, healthcare preventative interventions including lifestyle physical activity and nutrition, and views on tackling obesity.
Parents’ perspectives and experience revealed eleven themes centred around living with a child with obesity, risks and impact of obesity diseases; access to lifestyle nutritional and physical activity, and ethnicity specific barriers. Parents revealed social disadvantage, fear of victimisation by social services, perceptions on their cultural and religious traditions when dealing with nutrition and exercise, and child’s weight racial stigmatisation. Parents reported closer bonding with their children than health authorities to protect from obesity consequences. Work pressure, time, and lack of professionals’ guidance were seen as barriers to healthy lifestyle, while support from friends and family bond in adopting healthy lifestyle behaviours were facilitators. Parents reported no awareness of health service provision of nutritional and physical activity obesity prevention programmes.
Minority ethnic communities’ perspective on childhood obesity prevention does not match the healthcare system preventative offerings. Community and family-oriented obesity preventative approaches, especially lifestyle nutrition and physical activity interventions are needed beyond those administered by the primary healthcare system.
The Schwarzschild-de Sitter Metric of Nonlocal dS Gravity
Authors: Dimitrijevic Ivan , Dragovich Branko , Rakic Zoran , Stankovic Jelena
Published: April 2024

It is already known that a simple nonlocal de Sitter gravity model, which we denote as dS gravity, contains an exact vacuum cosmological solution which mimics dark energy and dark matter and is in very good agreement with the standard model of cosmology. This success of dS gravity motivated us to investigate how it works at lower than cosmic scale – galactic and the solar system. This paper contains our investigation of the corresponding Schwarzschild-de Sitter metric of the dS gravity model. To get exact solution, it is necessary to solve the corresponding nonlinear differential equation, what is a very complicated and difficult problem. What we obtained is a solution of linearized equation, which is related to space metric far from the massive body, where gravitational field is weak. The obtained approximate solution is of particular interest for examining the possible role of non-local de Sitter gravity dS in describing the effects in galactic dynamics that are usually attributed to dark matter. The solution has been tested on the Milky Way and the spiral galaxy M33 and is in good agreement with observational measurements.
Techno-Economic Evaluation on Solar-Assisted Post-Combustion CO2 Capture in Hollow Fiber Membrane Contactors
Authors: Mu Junkun , Bi Jinpeng , Lv Yuexia , Su Yancai , Zhao Wei , Zhang Hui , Du Tingting , Li Fuzhao , Zhou Hongyang
Published: April 2024

Membrane gas absorption technology and solar-assisted regeneration system are two promising approaches to reduce high energy consumption associated with carbon dioxide capture from coal fired power plants. In the present study, a solar-assisted hollow fiber membrane contactor (SOL-HFMC) power plant is proposed to capture and desorb CO2 in hollow fiber membrane contactors with the assistance of solar thermal collectors. Techno-economic assessment and sensitivity analysis of the proposed system is carried out in three studied locations with different weather conditions for a 580 MWe pulverized coal power plant. Research results show that, the output capacity and net efficiency of the SOL-HFMC power plant are significantly higher than those of the reference power plant regardless whether TES system is applied or not. In addition, CEI of the SOL-HFMC power plant with TES system is 4.36 kg CO2/MWh, 4.45 kg CO2/MWh and 4.66 kg CO2/MWh lower than that of the reference power plant. The prices of membrane, vacuum tube collector and phase change material should be reduced to achieve lower LCOE and COR values. Specifically for SOL-HFMC power plant with TES system, the corresponding vacuum tube collector price shall be lower than 25.70 $/m2 for Jinan, 95.20 $/m2 for Xining, and 128.70 $/m2 for Lhasa, respectively. To be more competitive than solar-assisted ammonia-based post-combustion CO2 capture power plant, the membrane price in Jinan, Xining and Lhasa shall be reduced to 0.012 $/m, 0.015 $/m and 0.016 $/m for the sake of LCOE, and 0.03 $/m, 0.033 $/m and 0.034 $/m for the sake of COR, respectively. The findings can provide guidance for decision-making and risk management strategies.
Role of Nutribiotics in Skin Care
Authors: Mourelle M. Lourdes , Gómez Carmen P. , Legido José L. , Pereira Leonel
Published: April 2024

The study of the human microbiome has been a hot topic during the last decades and more recently the skin microbiome has aroused great interest as well. So that, scientists have turned their attention to the role of the skin microbiome in skin health, and its relationship with different disorders as atopic dermatitis, psoriasis, acne, and rosacea, among others. Numerous studies and investigations have been performed to study the role of pre and probiotics as nutraceuticals in the treatment of skin diseases, with growing evidence along the last ten years. This review gathers information on the use of “nutribiotics” in skin care health, focus on the main dermatological diseases and other skin conditions. Clinical studies show that nutribiotics could be a new tool to improve skin health and pre, pro, syn, post and para-probiotics seem to be beneficial on several skin disorders, as well as repairing the skin barrier, or promoting wound healing. In conclusion, skin microbiome has emerged as a new field with high potential to develop disruptive solutions to manage skin health and disease. Future advances in this field may facilitate the treatment of skin dysbiosis being nutribiotics a suitable method for skin care.
A New Tailored Nano-Droplet Carrier of Astaxanthin Can Improve Its Pharmacokinetic Profile and Antioxidant Efficacy
Authors: Mishra Kumudesh , Khatib Nadin , Barasch Dinorah , Garti Sharon , Garti Nissim , Kakhlon Or
Published: April 2024

Astaxanthin (ATX) is a carotenoid nutraceutical with a poor bioavailability due to its high lipophilicity. We tested a new tailored nano-droplet capable of solubilizing ATX in an oil-in-water micro-environment (LDS-ATX, manufactured by Lyotropic Delivery Systems (LDS)), for its capacity to improve ATX pharmacokinetic profile and anti-oxidant efficacy. We used liquid chromatography tandem mass spectrometry (LC-MS/MS) to compare the pharmacokinetic profile of ATX and LDS-ATX and protein carbonylation and lipid peroxidation assays to compare their basal and lipopolysaccharide (LPS)-induced oxidative damage. Our results show that only LPS-induced oxidative damage was corrected by ATX and LDS-ATX. While in the liver and muscle LDS-ATX was more efficacious than ATX in attenuating oxidative damage to both proteins and lipids, only oxidative damage to lipids was preferably corrected by LDS-ATX in the brain. These results strongly suggest improvement of ATX bioavailability and efficacy by the LDS-ATX nano-formulation.
Questions and Answers in the Negative Footprint Illusion Paradigm: A Reply to Gorissen et al. (2024)
Authors: Sörqvist Patrik , Marsh John E.
Published: April 2024

When asked to estimate the carbon footprint of a bundle of relatively low carbon footprint items and relatively high carbon footprint items, people typically report a lower value compared to estimating the high carbon footprint items alone. This finding is called the negative footprint illusion and suggests people report the average rather than sum of the combined items’ carbon footprint. In a recent paper by Gorissen et al. (2024), the authors claimed that people are immune to this illusion if the question is framed differently. Specifically, they found that estimates of the environmental friendliness of a set comprising a burger (high carbon footprint) and an organic apple (low carbon footprint) was higher than for a set comprising the burger alone, whereas no difference was found between the two sets when participants were asked to estimate how environmentally damaging they were. Using larger item categories wherein the degree of the items’ environmental impact is clearly communicated, here we show it does not matter whether participants are required to estimate how friendly or damaging the items are. The roles of attribute substitution, dependent variables, and independent variables (stimulus characteristics) in modulating the negative footprint illusion is discussed.
The Whole Genome Sequence of Pseudomonas fernandeno sp. nov. from Soil and the Agricultural Discovery Pipeline
Authors: Senn Savanah , Best Meika , Robles Edgar , Kostoglou Mathew , Melendez Daila , Smith Karu , Pelka Robert , Spann Tracey , Vion Les , Watkins Gillian , Bowerman Adrianna L. , Chau Evelyn , Ford Jillian M. , Morvan Max , Nash Bruce
Published: April 2024

The purpose of this study was to identify candidate novel species performing beneficial ecological functions from soil. The hypothesis was that novel culturable species with antibiotic production potential could be readily found from soil in the Nature Canyon at Los Angeles Pierce College. 137 bacterial isolates from soil were grown on nutrient agar, ISP-6 medium, or LB agar and partial 16S was ascertained using the Sanger platform for regions V1-V4. One of the potentially novel isolates, Pseudomonas sp. 21-C3-ER, was isolated on nutrient agar from fallow soil in an agricultural nature preserve in Los Angeles. The soil conditions were 3.7% moisture, clay texture by touch, 13.37% organic matter, pH=6.63, TDS=638, 150 ppm nitrogen, 114 ppm phosphate, and 42 ppm potash. Whole genome sequencing was performed on the DNBseq platform and species identification was performed with TRUEBacID; the closest relative was Pseudomonas brassicacearum subsp. neoaurantiaca which was 92.05% similar by genomic evidence. 197 virulence factors were identified including flagellar biosynthesis, motor proteins, Beta-lactamase, Fosfomycin, copper, and sulfur drug resistance. Gram stain of strain 21-C3-ER revealed gram negative rods. Rods were visualized with scanning electron microscopy, revealing individuals approximately 1 µm in length. Secondary metabolite analysis using antiSMASH showed a variety of post-translationally modified proteins and a promysalin analog. The qualitative test for pyoverdine siderophore production using UV light was positive. Metabolic analysis using RAST indicated genes were present for pyoverdine production, antimicrobial resistance, and ammonification. The nitrate reduction test was positive. Denitrifying bacteria may prevent leaching of nitrates from soil, since ammonia has a higher affinity to soil and organic matter than nitrate. We propose Pseudomonas fernandeno as a novel species. The type stain is 21-C3-ER.
Within-week variation of training load in Turkish elite soccer players by players positions (a GPS technology study)
Authors: BAYRAKTAR Hakan , GÜNAY Erkan , Çene Erhan , Mancı Egemen , Akyıldız Zeki
Published: April 2024

Abstract
The of this study was to analyze the variation between within-week and between-playing positions on the locomotor and mechanical demands of soccer players. 19 elite soccer players of a team competing in the Turkish First League were included in the research. 86 training sessions of this team were evaluated. The differences between training performance metrics among microcycles for each position are revealed with repeated ANOVA and the differences between training performance metrics among positions in each microcycle are revealed with ANOVA. All the number of deceleration and acceleration per minute variables show statistical differences among the cycles for the defenders and midfielders but not for the forwards. These data suggested that there is a need to plan for different position-specific training stimuli in elite soccer teams for high performance outputs. We believe that these results can be used to determine positional demands by sports scientists and data analysts.

Keywords: Soccer, TRIMP, Workload, Players, Heart Rate, GPS, Microcycles.
From Order to Delivery: A Unified Omnichannel Framework for Dark Store
Authors: Caggiano Mariateresa , De Robertis Elvia , Ferrara Domenico , Loiacono Luigi , Liuzzi Francesco , Partipilo Marco , Pellicani Sergio , Zazzera Elvira
Published: April 2024

We present an integrated omnichannel framework designed for coordinating and improving shopping experience in the Health and Pharma (H&P) sector. The architecture of this unified purchasing system is composed by macros and subsystems designed for the scalability and flexibility of the framework in the specific context of H&P. In addition, we introduce an optimization algorithm specifically designed for the storage operations in a dark-store, with the aim of optimizing operational efficiency and reducing related costs. In the present study we propose two product allocation strategies in a vertical carousel warehouse, based on correlations between products. We show that the proposed optimized allocation strategy significantly reduces picking times compared to the random allocation strategy. Moreover, these results indicate that taking into account the correlation between products in past orders and the optimization of product arrangements within the warehouse can significantly improve the efficiency of the picking process.
Changes in Fecal Microbiome Associated with Parity in Lactating Bactrian Camels
Authors: Wang Jilite , Zhang Hongcai , Xu Jianxiong , Du Hongxi
Published: April 2024

To characterize the fecal microbiota of lactating Bactrian camels, this study employed a random selection of camels, assigning them to three groups: the first parity group, the third parity group, and the fifth parity group. The fecal microbial community of lactating camels was assessed using 16S rRNA amplicon sequencing, and the resulting library was sequenced on an Illumina NovaSeq platform. The first parity group was characterized by Verrucomicrobiaceae as a distinctive bi-omarker, whereas Clostridiaceae exhibited a similar role to the third parity group. In terms of functional analysis, the relative abundance of the Steroid biosynthesis pathway was highest in the first parity group, whereas the fifth parity group demonstrated a higher relative abundance of the Tuberculosis pathway compared to the other groups. The first parity group exhibited the greatest presence of seven types of enzymes, whereas the fifth parity group displayed the highest levels of two specific enzymes. Additionally, a positive association was observed between the relative abundance of the Steroid biosynthesis pathway and Verrucomicrobiaceae. Furthermore, the relative abundance of the Tuberculosis pathway displayed positive correlations with 14 enzymes. In conclusion, this study revealed that different parity was associated with distinct fecal microbial ecologies in lactating Bactrian camels.