bluuebunny/crossref_metadata_2025 huggingface dataset:
Condom use behavioural skills mediate the relationship between condom use motivation and condom use behaviour among young adult heterosexual males: An information-motivation-behavioural skills analysis
Authors: Camilleri Michelle , Kohut Taylor , Fisher William
Published: July 2015

This study examined the relationship between condom use motivation and condom use behavioural skills, and their direct and mediated influence on condom use consistency from the perspective of the Information-Motivation-Behavioural Skills (IMB) model of health behaviour. Participants were 149 currently sexually active heterosexual males aged 18–24 (M=18.6). The motivation component of the IMB model was operationalized with measures of attitudes toward condoms and perceptions of social norms, while assessing the implementation of negotiation strategies that can be used to obtain or avoid condom use operationalized the behavioural skills component. Results indicated that condom use motivation was positively correlated with specific condom use obtaining strategies, and condom use consistency was negatively correlated with certain condom use avoiding strategies. Moreover, specific condom negotiation strategies partially mediated the relationships between motivational constructs and condom use consistency. These findings confirm the propositions of the IMB model, illustrate the utility of measurement of behavioural skills in relation to implementation of specific actions, and highlight the need for interventions to focus on dyadic negotiation and communication strategies as important influences on condom use consistency. Implications for future research and theoretical refinement are discussed.
Is pornography use associated with anti-woman sexual aggression? Re-examining the Confluence Model with third variable considerations
Authors: Baer Jodie L. , Kohut Taylor , Fisher William A.
Published: July 2015

The Confluence Model of sexual aggression (Malamuth, Addison, & Koss, 2000) states that pornography use, thought to promote sexual coercion of women through presentation of submissive female imagery, works in conjunction with sexual promiscuity (SP) and hostile masculinity (HM), proposed sexual aggression risk factors, to produce anti-woman sexual aggression. An Internet based survey (N=183 adult males) replicated results of previous Confluence Model research, such that men who were high in HM and SP were more likely to report sexual coercion when they frequently, rather than infrequently, used pornography. Exploring new ground, this study also found that HM and SP together were strong predictors of consumption of violent sexual media, in comparison to non-violent sexual media, which suggests that men at high risk of sexual aggression consume different types of sexual material than men at low risk. Further, individual differences in sex drive were found to account for the effects previously attributed to pornography use in statistical tests of the Confluence Model. In the light of third variable considerations, these findings warrant a careful reappraisal of the Confluence Model's assertion that pornography use is a causal determinant of anti-woman sexual aggression.
The criminalization of sexual commerce in Canada: Context and concepts for critical analysis
Authors: Davies Jacqueline M.
Published: July 2015

Discussions of the rights and wrongs of sex for pay often occur in abstraction from the contexts in which they occur. Given the federal government's emphasis that its new legislation, The Protection of Communities and Exploitation of Persons Act, is a “made-in-Canada” solution to the problem of prostitution, the author examines Canadian legal, academic, activist, and mass media documents to explore made-in-Canada dimensions of the issues. A notable feature of the Canadian context is the long and ongoing history of policing of those perceived as prostitutes and their associates, as guilty of status offences. Social profiling and vulnerability to violence and exploitation in Canada also reflect the particular intersections of race, gender, class and nation in producing Canadian forms of sexual and other exploitations. Consideration of the implications for agency and passive subjugation in the terminology used to name the problem reveals ambiguities in the meaning of exploitation that reproduce a version of the status offence as well as environmental, waged labour and settler colonial forms of exploitation and injustice. Reference to indigenous, feminist, Kantian, and Marxist analyses of objectification and exploitation helps to reveal how this is occurs.
Long-term results of endoscopic third ventriculostomy: an outcome analysis
Authors: Vulcu Sonja , Eickele Leonie , Cinalli Giuseppe , Wagner Wolfgang , Oertel Joachim
Published: July 2015

OBJECT

Endoscopic third ventriculostomy (ETV) is the procedure of choice in the treatment of obstructive hydrocephalus. The excellent clinical and radiological success rates are well known. Nevertheless, very few papers have addressed the very long term outcomes of the procedure in very large series. The authors present a large case series of 113 patients who underwent 126 ETVs, and they highlight the initial postoperative outcome after 3 months and long-term follow-up with an average of 7 years.

METHODS

All patients who underwent ETV at the Department of Neurosurgery, Mainz University Hospital, between 1993 and 1999 were evaluated. Obstructive hydrocephalus was the causative pathology in all cases.

RESULTS

The initial clinical success rate was 82% and decreased slightly to 78% during long-term follow-up. Long-term success was analyzed using Kaplan-Meier curves. Overall, ETV failed in 31 patients. These patients underwent a second ETV or shunt treatment. A positive impact on long-term success was seen for age older than 6 months, and for obstruction due to cysts or benign aqueductal stenosis. The complication rate was 9% with 5 intraoperative and 5 postoperative events.

CONCLUSIONS

The high clinical success rate in short-term and long-term follow-up confirms ETV’s status as the gold standard for the treatment of obstructive hydrocephalus, especially for distinct pathologies. The patient’s age and underlying pathology may influence the outcome. These factors should be considered carefully preoperatively by the surgeon.
Post-carotid endarterectomy changes in cerebral glucose metabolism on 18F-fluorodeoxyglucose positron emission tomography associated with postoperative improvement or impairment in cognitive function
Authors: Yoshida Koji , Ogasawara Kuniaki , Saura Hiroaki , Saito Hideo , Kobayashi Masakazu , Yoshida Kenji , Terasaki Kazunori , Fujiwara Shunrou , Ogawa Akira
Published: July 2015

OBJECT

Cognitive function is often improved or impaired after carotid endarterectomy (CEA) for patients with cerebral hemodynamic impairment. Cerebral glucose metabolism measured using positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) correlates with cognitive function in patients with neurodegenerative diseases. The present study aimed to determine whether postoperative changes in cerebral glucose metabolism are associated with cognitive changes after CEA.

METHODS

In patients who were scheduled to undergo CEA for ipsilateral internal carotid artery (ICA) stenosis (≥ 70% narrowing), cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) to acetazolamide were assessed preoperatively using brain perfusion single-photon emission computed tomography (SPECT). CBF measurement using SPECT was also performed immediately after CEA. For patients with reduced preoperative CVR to acetazolamide in the cerebral hemisphere ipsilateral to surgery, cerebral glucose metabolism was assessed using FDG-PET before surgery and 3 months after surgery and was analyzed using 3D stereotactic surface projection. Neuropsychological testing was also performed preoperatively and 3 months postoperatively.

RESULTS

Twenty-two patients with reduced preoperative CVR to acetazolamide successfully underwent FDG-PET studies and neuropsychological testing before and after CEA. Seven, 9, and 6 patients were defined as showing improved, unchanged, and impaired postoperative cognition, respectively, based on the neuropsychological assessments. The cortical area with increased postoperative glucose metabolism was greater in patients with improved postoperative cognition than in those with unchanged (p < 0.001) or impaired (p < 0.001) postoperative cognition. The cortical area with decreased postoperative glucose metabolism was greater in patients with impaired postoperative cognition than in those with improved (p < 0.001) or unchanged (p < 0.001) postoperative cognition. All 7 patients with improved cognition exhibited postoperative hemispheric increases in glucose metabolism, while 5 of the 6 patients with impaired cognition exhibited postoperative hemispheric decreases in glucose metabolism. Brain perfusion SPECT revealed that the latter 6 patients experienced postoperative cerebral hyperperfusion, and 2 of the 6 patients exhibited cerebral hyperperfusion syndrome. The cortical area with decreased postoperative glucose metabolism in these 2 patients was greater than that in other patients.

CONCLUSIONS

Postoperative changes in cerebral glucose metabolism, as measured using FDG-PET, are associated with cognitive improvement and impairment after CEA.
Contemporary carotid imaging: from degree of stenosis to plaque vulnerability
Authors: Brinjikji Waleed , Huston John , Rabinstein Alejandro A. , Kim Gyeong-Moon , Lerman Amir , Lanzino Giuseppe
Published: July 2015

Carotid artery stenosis is a well-established risk factor of ischemic stroke, contributing to up to 10%-20% of strokes or transient ischemic attacks. Many clinical trials over the last 20 years have used measurements of carotid artery stenosis as a means to risk stratify patients. However, with improvements in vascular imaging techniques such as CT angiography and MR angiography, ultrasonography, and PET/CT, it is now possible to risk stratify patients, not just on the degree of carotid artery stenosis but also on how vulnerable the plaque is to rupture, resulting in ischemic stroke. These imaging techniques are ushering in an emerging paradigm shift that allows for risk stratifications based on the presence of imaging features such as intraplaque hemorrhage (IPH), plaque ulceration, plaque neovascularity, fibrous cap thickness, and presence of a lipid-rich necrotic core (LRNC). It is important for the neurosurgeon to be aware of these new imaging techniques that allow for improved patient risk stratification and outcomes. For example, a patient with a low-grade stenosis but an ulcerated plaque may benefit more from a revascularization procedure than a patient with a stable 70% asymptomatic stenosis with a thick fibrous cap.

This review summarizes the current state-of-the-art advances in carotid plaque imaging. Currently, MRI is the gold standard in carotid plaque imaging, with its high resolution and high sensitivity for identifying IPH, ulceration, LRNC, and inflammation. However, MRI is limited due to time constraints. CT also allows for high-resolution imaging and can accurately detect ulceration and calcification, but cannot reliably differentiate LRNC from IPH. PET/CT is an effective technique to identify active inflammation within the plaque, but it does not allow for assessment of anatomy, ulceration, IPH, or LRNC. Ultrasonography, with the aid of contrast enhancement, is a cost-effective technique to assess plaque morphology and characteristics, but it is limited in sensitivity and specificity for detecting LRNC, plaque hemorrhage, and ulceration compared with MRI.

Also summarized is how these advanced imaging techniques are being used in clinical practice to risk stratify patients with low- and high-grade carotid artery stenosis. For example, identification of IPH on MRI in patients with low-grade carotid artery stenosis is a risk factor for failure of medical therapy, and studies have shown that such patients may fair better with carotid endarterectomy (CEA). MR plaque imaging has also been found to be useful in identifying revascularization candidates who would be better candidates for CEA than carotid artery stenting (CAS), as high intraplaque signal on time of flight imaging is associated with vulnerable plaque and increased rates of adverse events in patients undergoing CAS but not CEA.
Aneurysm location and clipping versus coiling for development of secondary normal-pressure hydrocephalus after aneurysmal subarachnoid hemorrhage: Japanese Stroke DataBank
Authors: Yamada Shigeki , Ishikawa Masatsune , Yamamoto Kazuo , Ino Tadashi , Kimura Toru , Kobayashi Shotai , _ _
Published: July 2015

OBJECT

The present study aimed to investigate aneurysm locations and treatments for ruptured cerebral aneurysms associated with secondary normal-pressure hydrocephalus (sNPH) after subarachnoid hemorrhage (SAH) by using comprehensive data from the Japanese Stroke DataBank.

METHODS

Among 101,165 patients with acute stroke registered between 2000 and 2013, 4693 patients (1482 men, 3211 women) were registered as having had an SAH caused by a ruptured saccular aneurysm. Of them, 1448 patients (438 men and 1010 women; mean age 61.9 ± 13.4 years) who were confirmed to have or not have coexisting acute hydrocephalus and sNPH were included for statistical analyses. Locations of the ruptured aneurysms were subcategorized into 1 of the following 4 groups: middle cerebral artery (MCA; n = 354), anterior communicating artery and anterior cerebral artery (ACA; n = 496), internal carotid artery (ICA; n = 402), and posterior circulation (n = 130). Locations of 66 of the ruptured aneurysms were unknown/unrecorded. Treatments included craniotomy and clipping alone in 1073 patients, endovascular coil embolization alone in 285 patients, and a combination of coiling and clipping in 17 patients. The age-adjusted and multivariate odds ratios from logistic regression analyses were calculated after stratification using the Fisher CT scale to investigate the effects of the hematoma volume of SAH.

RESULTS

Acute hydrocephalus was confirmed in 593 patients, and 521 patients developed sNPH. Patients with a ruptured ACA aneurysm had twice the risk for sNPH over those with a ruptured MCA aneurysm. Those with an ACA aneurysm with Fisher Grade 3 SAH had a 9-fold-higher risk for sNPH than those with an MCA aneurysm with Fisher Grade 1 or 2 SAH. Patients with a ruptured posterior circulation aneurysm did not have any significant risk for sNPH. Clipping of the ruptured aneurysm resulted in twice the risk for sNPH over coil embolization alone.

CONCLUSIONS

Patients with low-grade SAH caused by a ruptured MCA aneurysm had a low risk for the development of sNPH. In contrast, patients with high-grade SAH caused by a ruptured ACA aneurysm had a higher risk for sNPH. Endovascular coiling might confer a lower risk of developing sNPH than microsurgical clipping.
Outcomes and factors associated with infant abusive head trauma in the US
Authors: Nuño Miriam , Pelissier Lindsey , Varshneya Kunal , Adamo Matthew A. , Drazin Doniel
Published: July 2015

OBJECT

Head trauma is the leading cause of death in abused children, particularly prior to the age of 2 years. An awareness of factors associated with this condition as well as with a higher risk of mortality is important to improve outcomes and prevent the occurrence of these events. The objective of this study was to evaluate outcomes and factors associated with poor outcomes in infants with diagnosed abusive head trauma (AHT). Patient characteristics, socioeconomic factors, and secondary conditions such as retinal bleeding, contusion, and fractures were considered.

METHODS

Data were obtained from the Healthcare Cost and Utilization Project of the Agency for Healthcare Research and Quality. From the Kids’ Inpatient Database (KID) sample, the authors identified infants no older than 23 months who had been diagnosed with AHT in 2000, 2003, 2006, and 2009. All statistical analyses were conducted in SAS 9.2. Descriptive statistics were provided, and multivariate logistic regression models were applied to evaluate factors associated with mortality and nonroutine discharge.

RESULTS

A total of 5195 infants were analyzed in this study. Most infants (85.5%) had ages ranging between 0 and 11 months and were male (61.6%). Overall mortality was 10.8%, with a rate of 9.8% in the 0- to 11-month-old cohort and 16.5% in the 12- to 23-month-olds (p = 0.0003). The overall nonroutine discharge rate of 25.6% increased significantly from 23.3% to 39.0% with increasing age (0–11 vs 12–23 months of age, p < 0.0001). Assuming a multivariate model that adjusted for multiple confounders, the authors found that older infants (12–23 vs 0–11 months, OR 1.81, 95% CI 1.18–2.77) with a secondary diagnosis of retinal bleeding (OR 2.85, 95% CI 2.02–4.00) or shaken baby syndrome (OR 2.09, 95% CI 1.48–2.94) had an increased risk of mortality; these factors were similarly associated with an increased odds of a nonroutine discharge. A higher income ($30,001–$35,000 vs $1–$24,999) was associated with a reduction in the odds of mortality (OR 0.46, 95% CI 0.29–0.72). In the subset of cases (1695 [32.6%]) that specified the perpetrator involved in infant injury, the authors found that the father, stepfather, or boyfriend was most frequently reported (67.4%). A trend for a higher AHT incidence was documented in the early ages (peak at 2 months) compared with older ages.

CONCLUSIONS

Despite the higher incidence of AHT among infants during the earlier months of life, higher mortality was documented in the 12- to 23-month-olds. Retinal bleeding and shaken baby syndrome were secondary diagnoses associated with higher mortality and nonroutine discharge. Males (67.4%) were overwhelmingly documented as the perpetrators involved in the injury of these infants.
Use of blood-sparing surgical techniques and transfusion algorithms: association with decreased blood administration in children undergoing primary open craniosynostosis repair
Authors: Nguyen Thanh T. , Hill Sarah , Austin Thomas M. , Whitney Gina M. , Wellons John C. , Lam Humphrey V.
Published: July 2015

OBJECT

Craniofacial reconstruction surgery (CFR) is often associated with significant blood loss, coagulopathy, and perioperative blood transfusion. Due to transfusion risks, many different approaches have been used to decrease allogeneic blood transfusion for these patients during the perioperative period. Protocols have decreased blood administration during the perioperative period for many types of surgeries. The object of this study was to determine if a protocol involving blood-sparing surgical techniques and a transfusion algorithm decreased intraoperative blood transfusion and blood loss.

METHODS

A protocol using transfusion algorithms and implementation of blood-sparing surgical techniques for CFR was implemented at Vanderbilt University on January 1, 2013. Following Institutional Review Board approval, blood loss and transfusion data were gathered retrospectively on all children undergoing primary open CFR, using the protocol, for the calendar year 2013. This postprotocol cohort was compared with a preprotocol cohort, which consisted of all children undergoing primary open CFR during the previous calendar year, 2012.

RESULTS

There were 41 patients in the preprotocol and 39 in the postprotocol cohort. There was no statistical difference between the demographics of the 2 groups. When compared with the preprotocol cohort, intraoperative packed red blood cell transfusion volume decreased from 36.9 ± 21.2 ml/kg to 19.2 ± 10.9 ml/kg (p = 0.0001), whereas fresh-frozen plasma transfusion decreased from 26.8 ± 25.4 ml/kg to 1.5 ± 5.7 ml/kg (p < 0.0001) following implementation of the protocol. Furthermore, estimated blood loss decreased from 64.2 ± 32.4 ml/kg to 52.3 ± 33.3 ml/kg (p = 0.015). Use of fresh-frozen plasma in the postoperative period also decreased when compared with the period before implementation of the protocol. There was no significant difference in morbidity and mortality between the 2 groups.

CONCLUSIONS

The results of this study suggested that using a multidisciplinary protocol consisting of transfusion algorithms and implementation of blood-sparing surgical techniques during major CFR in pediatric patients is associated with reduced intraoperative administration of blood product, without shifting the transfusion burden to the postoperative period.
Optimizing cerebrovascular surgical and endovascular procedures in children via personalized 3D printing
Authors: Weinstock Peter , Prabhu Sanjay P. , Flynn Katie , Orbach Darren B. , Smith Edward
Published: July 2015

OBJECT

Despite the availability of multiplanar imaging, understanding relational 3D anatomy for complex cerebrovascular lesions can be difficult. A 3D printed model allows for instantaneous visualization of lesional anatomy from all perspectives, with the added ability to simulate operative approaches with tactile feedback. The authors report their experience with customized 3D printed models of pediatric cerebrovascular lesions as an educational and clinical tool for patients, trainees, and physicians.

METHODS

Via an “in-house” 3D print service, magnetic resonance imaging (MRI) and computerized tomography (CT) studies of pediatric patients with arteriovenous malformations (AVMs) were processed with specialized software, and regions of interest were selected by the surgical/endovascular team. Multiple models for each patient were then printed on a 3D printer, with each construct designed to illustrate different aspects of the specific lesion. Intraoperative validation of model fidelity was performed using perioperative imaging, surgical filming, and post hoc analysis of models with intraoperative photography.

RESULTS

Four cases involving pediatric patients (ages 0–16 years) were studied for initial proof of principle. Three of the patients had AVMs and one had a vein of Galen malformation (VOGM). The VOGM was embolized successfully and the AVMs were resected without complication. In the AVM cases, intraprocedural imaging and photography were performed and verified millimeter-level fidelity of the models (n = 5, 98% concordance, range 94%–100% with average of < 2 mm variation in the largest AVM [6-cm diameter]). The use of 3D models was associated with a 30-minute reduction in operative time (12%) in 2 cases when they were compared with matched controls as a feasibility study.

CONCLUSIONS

Patient-specific 3D printed models of pediatric cerebrovascular conditions can be constructed with high fidelity. This proof-of-principle series demonstrates, for the first time, confirmation of model accuracy using intraprocedural assessment and potential benefit through shortened operative time.
Effect of the Standard Nomenclature for Air Pollution (SNAP) Categories on Air Quality over Europe
Authors: Tagaris Efthimios , Sotiropoulou Rafaella , Gounaris Nikos , Andronopoulos Spyros , Vlachogiannis Diamando
Published: July 2015

The contribution of different anthropogenic source-sectors on ozone mixing ratios and PM2.5 concentrations over Europe is assessed for a summer month (July 2006) using the US Environmental Protection Agency’s (EPA’s) Models-3 framework and the Netherlands Organization for Applied Scientific Research (TNO) anthropogenic emissions for 2006. Anthropogenic emission sources have been classified into 10 different Standard Nomenclature for Air Pollution (SNAP) categories. The road transport category, which is mainly responsible for NOX emissions, is estimated to have the major impact on Max8hrO3 mixing ratio suggesting an increase of 6.8% on average over Europe, while locally it is more than 20%. Power generation category is estimated to have the major impact on PM2.5 concentrations since it is the major source of SO2 emissions, suggesting an increase of 22.9% on average over Europe, while locally it is more than 60%. Agriculture category is also contributing significantly on PM2.5 concentrations, since agricultural activities are the major source of NH3 emissions, suggesting an increased by 16.1% on average over Europe, while in regions with elevated NH3 emissions the increase is up to 40%.
The Regulation of Reverse Cholesterol Transport and Cellular Cholesterol Homeostasis by MicroRNAs
Authors: DiMarco Diana , Fernandez Maria
Published: July 2015

MicroRNAs (miRNAs) are small, non-coding RNAs that have the ability to post-transcriptionally regulate gene expression. Hundreds of miRNAs have been identified in humans and they are involved in the regulation of almost every process, including cholesterol transport, metabolism, and maintenance of cholesterol homeostasis. Because of their small size and their ability to very specifically regulate gene expression, miRNAs are attractive targets for the regulation of dyslipidemias and other lipid-related disorders. However, the complex interactions between miRNAs, transcription factors, and gene expression raise great potential for side effects as a result of miRNA overexpression or inhibition. Many dietary components can also target specific miRNAs, altering the expression of downstream genes. Therefore, much more research is necessary to fully understand the role(s) of each miRNA in the body and how they may be impacted by diet and health. The present review aims to summarize the known roles of miRNAs in the regulation of reverse cholesterol transport and the maintenance of cholesterol homeostasis, as well as the potential clinical consequences of their manipulation.
Antibody Affinity Maturation in Fishes—Our Current Understanding
Authors: Magor Brad
Published: July 2015

It has long been believed that fish lack antibody affinity maturation, in part because they were thought to lack germinal centers. Recent research done on sharks and bony fishes indicates that these early vertebrates are able to affinity mature their antibodies. This article reviews the functionality of the fish homologue of the immunoglobulin (Ig) mutator enzyme activation-induced cytidine deaminase (AID). We also consider the protein and molecular evidence for Ig somatic hypermutation and antibody affinity maturation. In the context of recent evidence for a putative proto-germinal center in fishes we propose some possible reasons that observed affinity maturation in fishes often seems lacking and propose future work that might shed further light on this process in fishes.
The Internet Process Addiction Test: Screening for Addictions to Processes Facilitated by the Internet
Authors: Northrup Jason , Lapierre Coady , Kirk Jeffrey , Rae Cosette
Published: July 2015

The Internet Process Addiction Test (IPAT) was created to screen for potential addictive behaviors that could be facilitated by the internet. The IPAT was created with the mindset that the term “Internet addiction” is structurally problematic, as the Internet is simply the medium that one uses to access various addictive processes. The role of the internet in facilitating addictions, however, cannot be minimized. A new screening tool that effectively directed researchers and clinicians to the specific processes facilitated by the internet would therefore be useful. This study shows that the Internet Process Addiction Test (IPAT) demonstrates good validity and reliability. Four addictive processes were effectively screened for with the IPAT: Online video game playing, online social networking, online sexual activity, and web surfing. Implications for further research and limitations of the study are discussed.
MicroRNAs in Cancer: A Historical Perspective on the Path from Discovery to Therapy
Authors: Orellana Esteban , Kasinski Andrea
Published: July 2015

Recent progress in microRNA (miRNA) therapeutics has been strongly dependent on multiple seminal discoveries in the area of miRNA biology during the past two decades. In this review, we focus on the historical discoveries that collectively led to transitioning miRNAs into the clinic. We highlight the pivotal studies that identified the first miRNAs in Caenorhabditis elegans to the more recent reports that have fueled the quest to understand the use of miRNAs as markers for cancer diagnosis and prognosis. In addition, we provide insights as to how unraveling basic miRNA biology has provided a solid foundation for advancing miRNAs, such as miR-34a, therapeutically. We conclude with a brief examination of the current challenges that still need to be addressed to accelerate the path of miRNAs to the clinic: including delivery vehicles, miRNA- and delivery-associated toxicity, dosage, and off target effects.
Simple Preparation of Pd Core Nanoparticles for Pd Core/Pt Shell Catalyst and Evaluation of Activity and Durability for Oxygen Reduction Reaction
Authors: Inoue Hiroshi , Sakai Ryotaro , Kuwahara Taiki , Chiku Masanobu , Higuchi Eiji
Published: July 2015

Pd core nanoparticles less than 5 nm in mean size were prepared on carbon black (CB) without any stabilizer by using palladium acetate as a precursor and CO as a reducing agent, and then used for preparing Pd core/Pt shell nanoparticles-loaded CB (Pt/Pd/CB). The mean size of Pd nanoparticles could be controlled by the concentration of palladium acetate and the CO bubbling time. The cyclic voltammograms of two Pd nanoparticles-loaded CB (Pd4.2/CB, Pd3.3/CB) electrodes whose mean size was 4.2 and 3.3 nm, respectively, had characteristics similar to a Pt electrode after the formation of a Pt monolayer shell, suggesting that the Pd core nanoparticles were almost covered with the Pt monolayer shell. The oxygen reduction reaction (ORR) on both Pt/Pd/CB proceeded in 4-electron reduction mechanism. Both Pt/Pd/CB electrodes was ca. 1.5 times higher in ORR activity per electrochemical surface area of Pt (specific activity, SA) than the commercial Pt nanoparticles-loaded CB (Tanaka Kikinzoku Kogyo, Pt/CB-TKK) electrode, and the Pt/Pd3.3/CB electrode had higher SA than the Pt/Pd4.2/CB electrode. The ORR activity per unit mass of Pt for both Pt/Pd/CB electrodes was 5.0 and 5.5 times as high as that for the Pt/CB-TKK electrode, respectively. The durability of both Pt/Pd/CB electrodes was comparable to that of Pt/CB-TKK.
Lattice Wind Description and Characterization of Mexico City Local Wind Events in the 2001–2006 Period
Authors: Salcido Alejandro , Carreón-Sierra Susana , Georgiadis Teodoro , Celada-Murillo Ana-Teresa , Castro Telma
Published: July 2015

Urban transformation and expansion in Mexico City continuously affect its urban morphology, and therefore the modes of wind circulation inside it and their occurrence probabilities. Knowledge on these topics is an important issue for urban planning and for other urban studies, such as air quality assessment. In this paper, using a lattice wind model at a meso-β scale, we develop a simple description and characterization of Mexico City local wind events that occurred during the period 2001–2006, including an estimation of the occurrence probabilities. This region was modeled as a 2D lattice domain of identical cells, and wind conditions in each cell were described by four wind attributes: the horizontal velocity components, divergence, and vorticity. Models of one and four cells were applied to wind data furnished by the meteorological network of the city. Results include the following: Early morning: low intensity winds (75%) from N, NW, W and SW (75%), convergent (93%), with a slight predominance of cyclonic vorticity (54%). Morning and early afternoon: winds from N, NE and E (72%) with speeds from 0.5 to 3.5 m/s, slight prevailing of convergent winds (51%), and slight predominance of cyclonic vorticity (57%). Late afternoon and night: winds blowing from N, NW, and S (63%) with speeds from 1.5 to 3.5 m/s (66%), convergent (90%), and cyclonic (72%).
Thermal Behavior and Free-Radical-Scavenging Activity of Phytic Acid Alone and Incorporated in Cosmetic Emulsions
Authors: Daneluti André , Velasco Maria , Baby André , Matos Jivaldo
Published: July 2015

Phytic acid is a natural compound widely used as depigmenting agent in cosmetic emulsions. Few studies are available in the literature covering the stability and the antioxidating property of this substance, used alone or into emulsions. Therefore, the purpose of this work was to investigate the thermal behavior and antioxidant properties of phytic acid alone and into cosmetic emulsions. The thermal behavior of this substance was evaluated by thermogravimetry (TG)/derivative thermogravimetry (DTG) and differential scanning calorimetry (DSC) and the free-radical-scavenging activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH). TG/DTG and DSC curves allowed evaluation of the thermal behavior of phytic acid. These results showed that the substance presented four stages of mass loss. Thermal decomposition of the material initiated at 150 °C. Thermal behavior of the cosmetic emulsions detected that the addition of phytic acid decreased the thermal stability of the system. DPPH free-radical-scavenging activity showed that phytic acid incorporated into emulsion had no antioxidant capacity compared to BHT. In summary, we concluded that the thermoanalytical techniques (TG and DSC) were efficient and reliable in the characterization of phytic acid alone and incorporated into cosmetic emulsions.
Prebiotic Competition between Information Variants, With Low Error Catastrophe Risks
Authors: Popa Radu , Cimpoiasu Vily
Published: July 2015

During competition for resources in primitive networks increased fitness of an information variant does not necessarily equate with successful elimination of its competitors. If variability is added fast to a system, speedy replacement of pre-existing and less-efficient forms of order is required as novel information variants arrive. Otherwise, the information capacity of the system fills up with information variants (an effect referred as “error catastrophe”). As the cost for managing the system’s exceeding complexity increases, the correlation between performance capabilities of information variants and their competitive success decreases, and evolution of such systems toward increased efficiency slows down. This impasse impedes the understanding of evolution in prebiotic networks. We used the simulation platform Biotic Abstract Dual Automata (BiADA) to analyze how information variants compete in a resource-limited space. We analyzed the effect of energy-related features (differences in autocatalytic efficiency, energy cost of order, energy availability, transformation rates and stability of order) on this competition. We discuss circumstances and controllers allowing primitive networks acquire novel information with minimal “error catastrophe” risks. We present a primitive mechanism for maximization of energy flux in dynamic networks. This work helps evaluate controllers of evolution in prebiotic networks and other systems where information variants compete.
Escalation with Overdose Control is More Efficient and Safer than Accelerated Titration for Dose Finding
Authors: Rogatko André , Cook-Wiens Galen , Tighiouart Mourad , Piantadosi Steven
Published: July 2015

The standard 3 + 3 or “modified Fibonacci” up-and-down (MF-UD) method of dose escalation is by far the most used design in dose-finding cancer trials. However, MF-UD has always shown inferior performance when compared with its competitors regarding number of patients treated at optimal doses. A consequence of using less effective designs is that more patients are treated with doses outside the therapeutic window. In June 2012, the U S Food and Drug Administration (FDA) rejected the proposal to use Escalation with Overdose Control (EWOC), an established dose-finding method which has been extensively used in FDA-approved first in human trials and imposed a variation of the MF-UD, known as accelerated titration (AT) design. This event motivated us to perform an extensive simulation study comparing the operating characteristics of AT and EWOC. We show that the AT design has poor operating characteristics relative to three versions of EWOC under several practical scenarios. From the clinical investigator’s perspective, lower bias and mean square error make EWOC designs preferable than AT designs without compromising safety. From a patient’s perspective, uniformly higher proportion of patients receiving doses within an optimal range of the true MTD makes EWOC designs preferable than AT designs.
Double Blind Peer-Review in Education Sciences
Authors: Albright James , Rittman Martyn
Published: July 2015

We are pleased to announce that all manuscripts submitted to Education Sciences after 1 July 2015 will be reviewed using a double blind peer-review process. [...]
An Improved Weise’s Rule for Efficient Estimation of Stand Quadratic Mean Diameter
Authors: Sedmák Róbert , Scheer Ľubomír , Marušák Róbert , Bošeľa Michal , Sedmáková Denisa , Fabrika Marek
Published: July 2015

The main objective of this study was to explore the accuracy of Weise’s rule of thumb applied to an estimation of the quadratic mean diameter of a forest stand. Virtual stands of European beech (Fagus sylvatica L.) across a range of structure types were stochastically generated and random sampling was simulated. We compared the bias and accuracy of stand quadratic mean diameter estimates, employing different ranks of measured stems from a set of the 10 trees nearest to the sampling point. We proposed several modifications of the original Weise’s rule based on the measurement and averaging of two different ranks centered to a target rank. In accordance with the original formulation of the empirical rule, we recommend the application of the measurement of the 6th stem in rank corresponding to the 55% sample percentile of diameter distribution, irrespective of mean diameter size and degree of diameter dispersion. The study also revealed that the application of appropriate two-measurement modifications of Weise’s method, the 4th and 8th ranks or 3rd and 9th ranks averaged to the 6th central rank, should be preferred over the classic one-measurement estimation. The modified versions are characterised by an improved accuracy (about 25%) without statistically significant bias and measurement costs comparable to the classic Weise method.
Enriching ALS-Derived Area-Based Estimates of Volume through Tree-Level Downscaling
Authors: Tompalski Piotr , Coops Nicholas , White Joanne , Wulder Michael
Published: July 2015

Information on individual tree attributes is important for sustainable management of forest stands. Airborne Laser Scanning (ALS) point clouds are an excellent source of information for predicting a range of forest stand attributes, with plot and single tree volume being among the most important. Two approaches exist for estimating volume: area-based approach (ABA) and individual tree detection (ITD). The ABA is now routinely applied in operational forestry applications, and results in generalized plot- or stand-level attribute predictions. Alternatively, ITD-based estimates provide detailed information for individual trees, but are typically biased due to challenges associated with individual tree detection. In this study, we applied an ABA to estimate tree counts and individual tree volumes by downscaling plot-level predictions of total volume derived using ALS data in a highly productive and complex coastal temperate forest environment in British Columbia, Canada, characterized by large volumes and multi-species and multi-age stand structures. To do so, a two-parameter Weibull probability density function (PDF) was used to describe the within-plot tree volume distribution. The ABA approach was then used to model the total plot volume and the two Weibull PDF parameters. Next, the parameters were used to calculate mean tree volume and derive the number of trees and the individual tree volume distribution. Tree count estimates were minimally biased with RMSE of 149 trees·ha−1 or 24.4%. The volume distributions showed good agreement with reference data (mean Reynold’s error index = 71.7). We conclude that the approach was suitable for enriching ABA-derived forest stand attributes in the majority of the studied forest stands; however the accuracy was lower in multi-layered stands that had a multimodal individual tree volume distribution.
Prevalence of Sodium and Fluid Restriction Recommendations for Patients with Pulmonary Hypertension
Authors: Zeiger Tonya , Cobo Giovanna , Dillingham Christine , Burger Charles
Published: July 2015

Background: Patients with pulmonary hypertension (PH) are often afflicted with the consequences of right heart failure including volume overload. Counseling to assist the patient in the dietary restriction of sodium and fluid may be underutilized. Methods: Consecutive patients seen in the PH Clinic at Mayo Clinic in Florida from June to November 2013. Results: 100 patients were included; 70 were women and most had group 1 PH (n = 69). Patient characteristics using mean (±SD) were: Age 63 ± 13 years, functional class 3 ± 1, brain natriuretic peptide 302 ± 696 pg/mL, 6-min walk 337 ± 116 m, right atrial pressure 8 ± 5 mmHg, and mean pulmonary artery pressure 42 ± 13 mmHg. Overall, 79 had had complete (32) or partial instruction (47) and 21 had no prior counseling to restrict sodium or fluid. Of the 47 with partial instruction, 42 received complete education during the PH Clinic visit. Of the 21 without prior instruction, 19 received complete education during the PH visit. Seven patients with the opportunity to have their education enhanced or provided did not receive any additional counseling during the PH visit. Conclusion: Sodium and fluid restriction is an important but perhaps underutilized strategy to manage volume overload in patients with right heart failure. Focused questioning and education may permit an increase in the patients receiving instruction in this regard.
Perspectives on Smoking Initiation and Maintenance: A Qualitative Exploration among Singapore Youth
Authors: Subramaniam Mythily , Shahwan Shazana , Fauziana Restria , Satghare Pratika , Picco Louisa , Vaingankar Janhavi , Chong Siow
Published: July 2015

Studies among adolescents have shown that several important interpersonal, intrapersonal and environmental factors are associated with smoking behaviour. The current qualitative research project aimed to explore the determinants of smoking initiation and maintenance, from a youth perspective, among young people who smoked, living in a multi-ethnic Asian country. Focus group discussions (FGDs) were conducted with youths in Singapore in youth-friendly and accessible locations. Young people, from a variety of social contexts—varying on age, gender, ethnicity and educational level, were included in the study. All FGDs were conducted in English and participants were recruited using a mix of network and purposive sampling. All FGDs were audio recorded and transcribed verbatim. The data were analyzed using qualitative content analysis, allowing themes to emerge from the data with the goal of answering the research question. Ninety-one youth smokers (54 males, 37 females), aged between 14 to 29 years, participated in the study. The majority were males (59%) and of Chinese ethnicity (52%). Participants identified multiple personal, social, and familial influences on young adults’ smoking behaviors. Peer and family influences, as well as risk minimization, played a key role in smoking initiation and maintenance. While young people were aware of policies that restricted smoking, these did not directly affect their decision to start smoking. The theory of triadic influence provided a promising theoretical framework to understand smoking initiation and maintenance in a sample of young adult smokers from a multi-ethnic Asian country. It also provides actionable information for initiatives to prevent smoking in young people, which includes their perspectives and emphasizes an inclusive approach without stigmatizing those who smoke.
Integrated Assessment of Artisanal and Small-Scale Gold Mining in Ghana—Part 2: Natural Sciences Review
Authors: Rajaee Mozhgon , Obiri Samuel , Green Allyson , Long Rachel , Cobbina Samuel , Nartey Vincent , Buck David , Antwi Edward , Basu Niladri
Published: July 2015

This paper is one of three synthesis documents produced via an integrated assessment (IA) that aims to increase understanding of artisanal and small-scale gold mining (ASGM) in Ghana. Given the complexities surrounding ASGM, an integrated assessment (IA) framework was utilized to analyze socio-economic, health, and environmental data, and co-develop evidence-based responses with stakeholders. This paper focuses on the causes, status, trends, and consequences of ecological issues related to ASGM activity in Ghana. It reviews dozens of studies and thousands of samples to document evidence of heavy metals contamination in ecological media across Ghana. Soil and water mercury concentrations were generally lower than guideline values, but sediment mercury concentrations surpassed guideline values in 64% of samples. Arsenic, cadmium, and lead exceeded guideline values in 67%, 17%, and 24% of water samples, respectively. Other water quality parameters near ASGM sites show impairment, with some samples exceeding guidelines for acidity, turbidity, and nitrates. Additional ASGM-related stressors on environmental quality and ecosystem services include deforestation, land degradation, biodiversity loss, legacy contamination, and potential linkages to climate change. Though more research is needed to further elucidate the long-term impacts of ASGM on the environment, the plausible consequences of ecological damages should guide policies and actions to address the unique challenges posed by ASGM.
Forecasting Returns with Fundamentals-Removed Investor Sentiment
Authors: Stivers Adam
Published: July 2015

The Baker and Wurgler (2006) sentiment index purports to measure irrational investor sentiment, while the University of Michigan Consumer Sentiment Index is designed to largely reflect fundamentals. Removing this fundamental component from the Baker and Wurgler index creates an index of investor sentiment that may better capture irrational sentiment. This new index predicts returns better than the original Baker and Wurgler index as well as the alternative Baker and Wurgler sentiment index.
Molecular Characterization of Bovine SMO Gene and Effects of Its Genetic Variations on Body Size Traits in Qinchuan Cattle (Bos taurus)
Authors: Zhang Ya-Ran , Gui Lin-Sheng , Li Yao-Kun , Jiang Bi-Jie , Wang Hong-Cheng , Zhang Ying-Ying , Zan Lin-Sen
Published: July 2015

Smoothened (Smo)-mediated Hedgehog (Hh) signaling pathway governs the patterning, morphogenesis and growth of many different regions within animal body plans. This study evaluated the effects of genetic variations of the bovine SMO gene on economically important body size traits in Chinese Qinchuan cattle. Altogether, eight single nucleotide polymorphisms (SNPs: 1–8) were identified and genotyped via direct sequencing covering most of the coding region and 3ʹUTR of the bovine SMO gene. Both the p.698Ser.>Ser. synonymous mutation resulted from SNP1 and the p.700Ser.>Pro. non-synonymous mutation caused by SNP2 mapped to the intracellular C-terminal tail of bovine Smo protein; the other six SNPs were non-coding variants located in the 3ʹUTR. The linkage disequilibrium was analyzed, and five haplotypes were discovered in 520 Qinchuan cattle. Association analyses showed that SNP2, SNP3/5, SNP4 and SNP6/7 were significantly associated with some body size traits (p < 0.05) except SNP1/8 (p > 0.05). Meanwhile, cattle with wild-type combined haplotype Hap1/Hap1 had significantly (p < 0.05) greater body length than those with Hap2/Hap2. Our results indicate that variations in the SMO gene could affect body size traits of Qinchuan cattle, and the wild-type haplotype Hap1 together with the wild-type alleles of these detected SNPs in the SMO gene could be used to breed cattle with superior body size traits. Therefore, our results could be helpful for marker-assisted selection in beef cattle breeding programs.