bluuebunny/crossref_metadata_2025 huggingface dataset:
The Inhibition of Angiotensin-Converting Enzyme 2 Receptors of SARS-CoV-2 Through Mucroporin Derived from Scorpion Venom
Authors: Muhammad Fakih Taufik , Luthfika Dewi Mentari , Syahroni Eky
Published: December 2022

The SARS-CoV-2 virus that causes COVID-19 has a spike glycoprotein that can bind to a host cell receptor, angiotensin-converting enzyme 2 (ACE-2). This plays an important role in the entry of viral cells. Therefore, targeting of the ACE- 2 receptor holds promise as a potential target for anti-viral interventions to prevent and inhibit COVID-19. This study aims to focus on in silico studies to screen alternative drugs that can block ACE-2 receptor properties as a receptor for SARS- CoV-2. It is a potential therapeutic target for COVID-19 using the bioactive peptide Mucroporin which is derived from scorpion venom. There were four sequences of Mucroporin peptides modeled using the PEP-FOLD 3.5 server. The protein- peptide-based molecular docking simulations were used to identify and evaluate the actions of Mucroporin against ACE-2 receptors using PatchDock. The best response is then further observed using BIOVIA Discovery Studio 2020. This study revealed that Mucroporin and Mucroporin-S1 gave the best docking scores compared to Mucroporin-M1 and Mucroporin-S2, with the binding free energy values of −943.53 kJ/mol, −162.42 kJ/mol, 867.80 kJ/mol and 43.14 kJ/mol respectively. This study reveals for the first time that Mucroporin and Mucroporin-S1 are functional inhibitors of ACE-2 and as such, that components of scorpion venom can be used as potential inhibitors to the ACE-2 receptor of SARS-CoV-2.
Keywords: SARS-CoV-2; COVID-19; Angiotensin-Converting Enzyme 2 (ACE-2); Mucroporin; In Silico Study
KOPIDShield: Safety Partitions as a Novel Approach for Health-Worker's Protection during the Covid-19 Pandemic
Authors: Tejasari M. , Triyani Y. , Respati T. , Purbaningsih W. , Yuniarti L.
Published: December 2022

Several tests have been developed for Covid-19 diagnosis. One of these tests is a PCR examination with a swab sample. The infection transmission risk to health workers during swab sampling is very high so an adequate protection standard is paramount. A special PPE for Covid-19 specimens’ collection that is safer and can be used for a long time needs to be developed. The study aims to develop a prototype safe facility for collecting Covid-19 specimens with a high level of biosafety standard to prevent infection transmission, ergonomic, and can be used for an extended time. Applied research methods were used to produce a safety partition for Covid-19 specimen collection. The result was a safety partition prototype named KOPIDShield. It is completely impermeable to prevent the transmission of infectious agents from patients to health workers. It is equipped with supporting equipment that allows accurate specimen collection.
Keywords: biosafety, Covid-19, health_ worker_protection, personal_ protection_equipment, transmission_prevention
Synthesizing Cylic Peptides with Antioxidant Properties using Solid Phase Peptide Synthesis as an Alternative to Natural Product Isolation from Pork
Authors: Kurniaty N. , Rosyidah U. , Suparman A. , Yulianti R. , Sopiah S. , M. Baharudin W.
Published: December 2022

Tetrapeptides Ser-Leu-Tyr-Ala and Tyr-Leu-Tyr-Ala are two derivates that have been successfully isolated from the pork and synthesized using Solid Phase Peptide Synthesis (SPPS) method. Tetrapeptide Gly-Ala-Trp-Ala has also been successfully isolated from the Sardinella aurita fish found in Atlantic Ocean using SPPS. This study aims to synthesize tetrapeptide Ser-Leu-Tyr-Ala, Tyr-Leu-Tyr-Ala and Gly-Ala-Trp-Leu using the SPPS method, and to find the antioxidant properties of the synthesized tetrapeptides using DPPH test. The three tetrapeptides have been synthesized using 2-chlorotritilchloride resin as solid phase, Fmoc group protection, and coupling reagent HBTU/HOBt. HR-TOF-MS with m/z was [M+H]+ 453,23 and [2M+H]+ 905,49 for Ser- Leu-Tyr-Ala, [M+H]+114,61 for Tyr-Leu-Tyr-Ala and [M+H]+ 446,23 for Gly-Ala-Trp-Leu. The antioxidant properties of Ser-Leu-Tyr- Ala had an IC50 value of 11130,04 mg/ml, while the antioxidant properties of Tyr-Leu-Tyr-Ala had an IC50 value of 4319,522 mg/ml.
Keywords: solid phase peptide synthesis, antioxidant
Procalcitonin, but not D-dimer, is an Inapplicable Biomarker for Severe COVID-19
Authors: Muflihah H. , B. Rahiman S. , S. Sastramihardja H. , A. Yulianto F.
Published: December 2022

Pro-calcitonin and D-dimer are among predictive biomarkers for the severity and mortality of COVID-19. The application of these parameters in the clinical setting of Indonesian hospitals is less documented. This study aims to evaluate the association between procalcitonin and D-dimer with COVID-19. This research is part of a retrospective study evaluating 249 hospitalized COVID-19 patients in Bandung, Indonesia. Patients who were positive for procalcitonin or D-dimer were selected. Clinical data of age, sex, comorbid condition, peripheral oxygen saturation (SpO2), and death were assessed. There were 39 and 28 patients tested for procalcitonin and D-dimer respectively. The level of procalcitonin was not associate with the severity of COVID-19 (p=0.442), death (p=0.506), comorbid condition (p=0.601) or the use of the antibiotics. However, the level of D-dimer in patients with severe COVID-19 was significantly higher than those with non-severe COVID-19 (p=0.0468). Our study shows that procalcitonin levels are not associated with COVID-19. However, D-dimer is associated with the severity of COVID-19.
Keywords: COVID-19, D-dimer, procalcitonin, severity
Developing Open-Air Sports Facilities to Enhance Socio- Family Relations
Authors: Susanto V. , S. Ekomadyo A.
Published: December 2022

Ice skating is a prominent winter sport, and ice rinks provide an excellent place for socio-family relation enhancement, which means that sports are indeed a great tool to enhance parents’ and children’s bond. Most ice rinks were built indoors in Southeast Asia since the climate is not suitable for outdoor-built facilities. Unfortunately, the COVID-19 pandemic raised a new challenge for this sport’s development. This study aims to determine whether an outdoor ice rink can be built in a tropical climate that also serves as a place for socio-family relationships to blossom. The method utilized is a research-based design where observational data from several ice rinks was interpreted into the notion of a healthy sports facility that is a synthetic ice rink with its technical advantages and unique atmosphere, setting an example of thoughtful design in correlation to a sport’s development. This innovative design concept offers a new attraction as open-air rinks add to the scenery, are energy-efficient, and are cost-effective since their maintenance is cheaper than mechanical, indoor ice rinks.
Keywords: ice rink, socio-family relations
Design Factors and Criteria for Building a Non-Level Pedestrian Crossing at an Urban Campus
Authors: S. Pradifta F. , Damayanti V. , Weishaguna W. , R. S. Prayoga W. , A. Fadlimat A.
Published: December 2022

Bandung Islamic University (UNISBA) is in a densely populated urban area of Bandung. UNISBA lecture and administrative buildings are scattered in several locations. In architecture typo-morphology terms, a campus building with this environmental setting is often referred to as an urban campus. The high traffic flow on these roads, together with the intense conflict between road crossers, often results in congestion due to vehicle deceleration needed to allow pedestrian crossing. To facilitate the need for the movement for the users of the UNISBA campus buildings and minimize conflicts with road users, infrastructure that connects the UNISBA campus buildings is needed to facilitate pedestrian crossing. The pedestrian crossing could be in the form of a level crossing in the same elevation as the road or a non-level crossing situated above or under the road. The type of pedestrian crossing studied in this paper is a non-level pedestrian crossing in the form of a pedestrian bridge. In designing the infrastructure for non-level crossings, it is necessary to pay attention to the movement patterns that occur and the factors that influence willingness to use. This study aims to determine the movement pattern of UNISBA campus facility users consisting of students, lecturers, educational staff, and visitors by using quantitative origin-destination spatial analysis. Descriptive exploratory factor analysis was also used to determine the preferences of the users of the UNISBA campus buildings to use non-level crossings. The results of this analysis will be the basis for designing non-level accessibility between UNISBA campus buildings.
Keywords: pedestrian crossing, pedestrian bridge, urban campus, urban design, urban mobiity
How Accessible is Tourism for People With Disabilities?
Authors: Puspitasari Rochman Gina , . Afiati , Syaodih Ernady , Risang Aji Riswandha
Published: December 2022

but no one has examined specifics based on the type/specificity of persons with disabilities. This study compares the accessibility of tourism for people with hearing, blind, and physical disabilities based on their needs and experiences. This study uses a qualitative-comparative approach with content qualitative analysis. Interviews were conducted with key informants, namely people with deaf, blind, and physical disabilities who have experience traveling in the city of Bandung and its surroundings. Based on the results of the analysis, this study concluded that the deaf have greater access to tourism attractions than the blind. The availability of guides or assistants affects the accessibility of tourism for the blind, the availability of infrastructure or visual media affects the accessibility of tourism for the deaf, and the availability of physical infrastructure affects the accessibility of tourism for the physically disabled. This affects the opportunities for persons with disabilities to have attractive and comfortable travel experiences known as friendly tourism. This study recommends improving the accessibility to tourism for persons with disabilities by focusing on improving main services and infrastructure according to the needs of those with the disability.
Keywords: disabilities, friendly tourism, accessibility, infrastructure
Development of Feminine Area Cleansers with Anti-fungal Properties Using Apple Rose Leaves as an Active Ingredient
Authors: Suwendar S. , Wahidah L. , Krisnamurti Y. , L. Ridwan M. , Lestari W. , Mardliyani D. , Fitriani N.
Published: December 2022

Fungal infection has a high prevalence rate in the feminine area. The use of natural anti-fungal, natural feminine cleansers can be a solution to this problem. Apple rose leaves are thought to be an alternative active ingredient to be developed into a natural feminine area cleanser. In this study, in vitro antifungal activity of guava leaves was observed on Candidia albicans and their development into a feminine area cleanser. The results based on the ethanol extract, n-hexane fraction, ethyl acetate fraction and water fraction showed that there were high anti-fungal properties. The highest anti-fungal effect was shown by the n-hexane fraction. A feminine area cleanser was developed with the n-hexane fraction of apple rose leaves as the active ingredient. Pharmaceutic evaluation showed that the formulation obtained was milky white, odorless, homogeneous, produced foam with a height of 0.5 cm and had a pH of 4.5. Based on the results of the study, it can be concluded that apple rose leaves have the potential to be developed into a feminine area cleanser.
Keywords: apple rose leaves, leukorrhea, natural anti-leukorrhea, feminine area cleansing preparation
Comparison Between Different Herbal Formulations of Roses and Their Therapeutic Potential
Authors: Bhekti Rahimah Santun , S. Sastramihardja Herry , Kania Dewi Miranti , Andriane Yuke , Devi Trusda Annisa
Published: December 2022

Roses are one of the most popular flowers in the world, not only because of their beauty but also because they have medicinal properties. Drugs developed from roses must be support from various parties. Roses have active components that can be used to improve public health, such as anthocyanins, tannins and other active compounds. Making the right rose water herbal mixtures will help filter out the active substances according to the expected therapeutic effect. The manufacture of herbal mixtures of roses can vary, namely, infusions, extracts and rose oil. These three variations require different procedures. The three herbal formulations can provide an initial condition of the content of the active substances in the roses. The results of the rose infusion gave a red color in a short time, while the maceration of the extract with ethyl alcohol, methanol and hexsan gave a varied color appearance, while the identification of rose oil using water distillation did not show any filtered oil. The comparison of the three preparations shows that the herbal formulations can be done in a simple way and the formulation that gives the best results is rose water infusions that produces rose water.
Keywords: herbal preparation, rose infusion, rose oil, rose extract
The Contribution of the Agricultural Sector to Community Welfare in the Cirebon District
Authors: Mardhatilla F. , S. W. Atmaja I. , Hartono E. , Hidayat F. , Ferdianto F.
Published: December 2022

Gedong Gincu mango (GGM) is a leading commodity in the Cirebon district. It’s cultivated intensively in five sub-districts and is a source of income for the community. The study aimed to analyze the contribution of the agriculture sector to community welfare, especially in the Cirebon district. This research was conducted from August to October 2020 in the five sub-districts that produce GGM. Descriptive, quantitative field surveys were provided to 300 participants and multiple linear regression models were used to analyze the data. The results showed that the agricultural sector has contributed to the GRDP, but the extent to which it does so varied between the five sub-districts. The agricultural sector in the Sedong and Greged sub district had the highest contribution to the GRDP, but they both have the lowest score on the Human Development Index (HDI). This suggested that the existence of a leading GRDP does not guarantee high community welfare in GGM producing areas. HDI was found to have a strong correlation to the GRDP of an area. Economic development affects community welfare as suggested by the HDI.
Keywords: gedong gincu mango, human development index, gross regional domestic
In-Silico Investigation of Beta-Cyclodextrin as a Stabilizer for Pineapple Peel Extract Mediated Silver Nanoparticles
Authors: A. Wisnuwardhani H. , Lukmayani Y. , M. Yuliawati K. , Permanasari Y.
Published: December 2022

Pineapple peel waste was used in this study as a source of ferulic acid that has antioxidant and antibacterial properties. Pineapple peel extract can be used as a bioreductor in the synthesis of silver nanoparticles (AgNPs). Beta cyclodextrins are often added as stabilizers in the synthesis of AgNPs to increase their stability. This study aimed to investigate through in silico study the efficacy of beta cyclodextrin as a stabilizer in the synthesis of AgNPs. It also investigated whether ferulic acid plays the role of a bioreductor in the stabilization mechanism of the AgNPs. Molecular docking simulation was used to investigate the efficacy of beta cyclodextrin as a stabilizer in AgNPs synthesis using MGLTools 1.5.6 with AutodockTools 4.2. The visualization of each complex was observed using BIOVIA Discovery Studio Visualizer 2020. The results of this study showed that beta cyclodextrin had better affinity by stabilizing six AgNPs atoms, which was indicated by a free binding energy value of -5.15 kJ/mol. The presence of ferulic acid in the extract which was used as a bioreductor in the synthesis of AgNPs also had a better affinity for the six AgNPs atoms which was indicated by free binding energy of -2.51 kJ/mol. It can be concluded that beta cyclodextrins play the role of being a stabilizer in AgNPs synthesis.
Keywords: in silico, beta-cyclodextrin, silver nanoparticles
Formulation of Natural, Antiseptic Liquid from Jujube Leaf Extract for Islamic Dead Body Bathing Procedures
Authors: T. Maulana I. , Darusman F. , Mulqie L. , E. Priani S. , N. Maulidya E.
Published: December 2022

Ziziphus spina-christi L. or Jujube, is a plant that has many health benefits, containing metabolite compounds that act as an antibacterial agent such as alkaloids, flavonoids, saponins, tannins, and polyphenols. This study aimed to make a natural antiseptic liquid from Ziziphus spina-christi L. leaf extract used in Islamic Bathing Procedures for a corpse. The stages of this research included extraction, an assay of the extract’s antiseptic activity using the agar well diffusion method, formulating the antiseptic liquid, evaluating the antiseptic liquid, and examining the antiseptic properties of the liquid. Jujube leaf extract with a concentration of 10% was proven to have the best antibiotic properties with a very strong inhibition zone category. Antiseptic liquid formulations include extracts, DMDM hydantoin, Triethanolamine, and Aqua rose. The organoleptic evaluation results of liquid antiseptic were in the form of a homogeneous concentrate liquid, brown with a rose aroma, pH 9.048, the density of 1.020 g/mL, viscosity of 5.60 m.Pas, and 0.7 cm high foam with high foam stability of 83.33%. The antiseptic test results showed that the antiseptic solution was able to inhibit the growth of Escherichia coli, Staphylococcus epidermidis, and Candida albicans ranging from strong to very strong inhibition zone diameters, 17.35 mm, 21.10 mm, and 19.95 mm, respectively.
Keywords: antiseptic, antimicrobial, corpse bathing, jujube leaf (ziziphus spina christi L.)
Typhoid Pediatric Inpatient Clinical Symptoms, Laboratory and Antibiotic Treatment
Authors: Rayhana R. , S. Hernawan L.
Published: December 2022

Clinical features of typhoid fever vary from mild to severe. Laboratory examination for typhoid fever in Indonesia still uses the Widal test as a diagnostic tool. In 1992, isolates of S.typhi showed resistance to fluoroquinolones, with the first case reported in the United Kingdom. Similar cases were reported from several other countries, including India. This study aimed to describe the clinical symptoms, laboratory and antibiotics used for children with typhoid hospitalized at Hospital ‘X’ in West Java from January to March 2017. This research was a descriptive retrospective, using a cross-sectional design with a total sample of 127 respondents. The study was conducted from January to March 2018. Patients suffering from typhoid were hospitalized at Hospital ‘X’, West Java, were 37% aged between 5-9 years old with 51.18% males and those whose length of stay was for 3 days was 29.13%. Widal Titer O positive examination was 13.91% and positive H Titer was 45.21%, positive tubex 93.75%, 26.77% leukopenia, 48.81% with Hb value <11.5, the patient had a fever of 99.21%, 85.03% was given ceftriaxone. Clinical symptoms that are often experienced by children with typhoid typhoid is fever and the antibiotics that are often given are ceftriaxone.
Keywords: typhoid fever, widal titer, resistance
The Effectiveness of Leech Therapy in the Severity of Diabetic Neuropathy: A Randomized Controlled Trial
Authors: Alemi Farshad , Azimi Maryam , Moeini Reihaneh , Shirafkan Hoda , Bayani Mohammadali , Mojahedi Morteza , Tajadini Haleh
Published: December 2022

Diabetic peripheral neuropathy is one of the most common causes of disability in diabetic patients. Applying a method to achieve the highest therapeutic effect in patients is desirable. Therefore, this study aimed to evaluate the impact of leech therapy on diabetic neuropathy of lower limbs in comparison to gabapentin as a standard method. This randomized controlled parallel-group clinical trial was conducted among 40 patients with type II diabetes who were diagnosed with lower limb diabetic neuropathy and referred to specialized outpatient clinics in Babol, Mazandaran province, Iran from 23 September 2020 to 17 March 2021. The patients were randomly divided into two groups. One group was treated with leech therapy and the other group was treated with gabapentin as the standard method. The severity of neuropathy was assessed every 15 days until the 45th day. The Visual Analog Scale (VAS), Neuropathy Symptom Score (NSS), Neuropathy Disability Score (NDS), and Nerve Conduction Velocity (NCV), and Electromyography (EMG) were used for assessing the study outcomes. The repeated measure and Friedman tests were used by SPSS.V.23.  The results of our study indicated that pain (P value:0.03), numbness (P value˂0.0001), and paranesthesia (P value:0.01) significantly reduced in patients undergoing leech therapy versus patients taking gabapentin on the 45th day. The total NSS (P value˂0.0001) and total NDS (P value˂0.0001) improved significantly for patients with leech therapy over 45 days compared to the patients with gabapentin. The results of our study showed that using leech therapy for patients with diabetic neuropathy was more effective in improving clinical symptoms and the functions of lower limb muscles and nerves in comparison to gabapentin. The severity and symptoms of neuropathy greatly improved for the patients treated with leech therapy versus patients taking gabapentin.
Unraveling Traditional Knowledge of Ajuga iva (L.) Schreb. Used in the Fez-Meknes Area in Morocco
Authors: Lahrizi Laila , Errachidi Faouzi , Nekhla Houria , Ghadraoui Lahsen El
Published: December 2022

The traditional knowledge of Ajuga iva (L.) Schreb. used in Moroccan folk medicine may provide insight into its utilities for further in vitro and in vivo evaluation. The present work was undertaken with a view to highlighting one of the medicinal plants ''musk herb'', which has a wide geographical distribution in Morocco and which would be of great added value for the Moroccan pharmacopeia in general. An ethnopharmacological survey was conducted to interview a total of 207 informants, a questionnaire targeted the population of Fez-Meknes region. The interviewed people about the utility of A. iva confirmed the effectiveness of this plant in the treatment of numerous illnesses especially those affected digestive system (40.99%), headache (14.07%), fever (11.85%), and other pathologies represented 16.04%. The most part used is the leaves (48.30%) followed by the whole plant (43.47%). The present survey displays the importance of A. iva in the medical culture of Fez-Meknes population for the primary and secondary prevention of different disorders. Future mechanistic studies, as well as clinical trials, are needed to evaluate the safety and efficacy of this medicinal plant according to its ethnopharmacological uses.
Alpha-Mangostin Attenuates Oxidative Stress and Apoptosis in Scopolamine-Induced Amnesic Rat Brains
Authors: Changlek Suksan , Srisawat Rungrudee
Published: December 2022

The extract from Garcinia mangostana L. pericarp was reported to scavenge radicals, inhibit acetylcholinesterase (AChE) activity, and improve spatial memory in scopolamine (SCOP)-induced amnesic rats. This study investigated α-mangostin (α-MG) neuroprotective effects against SCOP-induced neurotoxicity.The compound was evaluated for anti-AChE and antioxidant properties in vitro, and its preventive effect on apoptosis and oxidative stress in SCOP-treated rat brains. AChE inhibitory property of α-MG was assessed by fast blue B (FB) salt and β-naphthyl acetate (NA) and Ellman’s assays. The antioxidant properties of α-MG were assessed by ferric reducing antioxidant power (FRAP), scavenging activity of 1,1-diphenyl-2-picrylhydrazyl (DPPH), and 2,2′-azino-bis-[3-ethylbenzothiazoline-6-sulfonic acid] (ABTS•+) radicals. Brain levels of malondialdehyde (MDA), lipid peroxidation marker, and activities of the caspase-3 enzyme, an apoptosis-related marker, were determined in SCOP-treated rats pretreated with donepezil (DPZ) and α-MG. IC50 of α-MG and DPZ for AChE activity were 64.23±0.22 and 32.46±0.14 mg/mL, respectively. α-MG and DPZ (100-600 µg/mL) gave FRAP values within the range of 20-410 µmol Fe2+/L. The IC50 of α-MG and DPZ for ABTS were 21.52±3.45 and 14.53±1.86 µg/mL, and for DPPH were 38.12±8.36 and 29.44±5.13 µg/mL, respectively. Prior given to SCOP-induced rats, DPZ and α-MG (50 and 100 mg/kg) reduced MDA levels, and pretreatment of DPZ and α-MG (50 mg/kg), but not α-MG (100 mg/kg), attenuated the increase of caspase-3 activity in cerebral cortex and hippocampus (P<0.05), but not in the basal forebrain. The present study is the first report of α-MG as a potential neuroprotective candidate, and its mechanism might be involved in ameliorating scopolamine-induced neurotoxicity via inhibition of lipid peroxidation and caspase-3 enzyme activity in the cerebral cortex and hippocampus.
Essential Oils Composition, Antibacterial Activity and Toxicity Study of Artemisia Species Growing in Ethiopia
Authors: Bibiso Mesfin , Anza Mathewos , Tadesse Takele
Published: December 2022

Artemisia essential oils have been used in flavors, scents, mice repellents, cleansers, beauty care products, fragrances, and conventional pharmaceuticals. This work analyzed the phytoconstituents, in vitro antibacterial activity, and toxicity of essential oils of three Artemisia species growing in Wolaita, Ethiopia. GC-MS has been used to analyze chemical composition. In vitro antibacterial activity was assessed by disc diffusion and broth dilution techniques. The MTT assay was used to conduct toxicity studies. The main components of the essential oil extracted from Artemisia afra Jacq. ex Willd. were camphor (19.2%), followed by 1,8-cineole (17.8%), artemisia ketone (15.2%), artemisyl acetate (6.9%), and camphene (6.6%). In the Artemisia annua L. oil, the main constituents were camphor (21.8%), artemisia alcohol (18.1%), santolina triene (11.6%), -copaene (9.1%), sabinene (4.5%), and δ-cadinene (4.0%). In addition, the main phytochemicals of Artemisia abyssinica Sch.Bip. ex A.Rich. oil were yomogi alcohol (39.3%), followed by cis β-farnesene (10.9%), β-selinene (6.7%), β-copaene (5.2%), and nerolidol (5.1%). The essential oils of A. afra, A. annua, and A. abyssinica showed significant antibacterial activity at low molar concentrations, with MIC values of 0.31, 0.15, and 0.62 μL against Staphylococcus aureus and 0.62, 0.31, and 1.25 μL against E. coli, respectively, compared with standard broad-spectrum gentamicin (0.25 μL). A. afra, A. annua, and A. abyssinica oils were showed weak toxicity to Vero cell lines with IC50 values of 178.47 µg/mL, 183.86 µg/mL, and 187.46 µg/mL, respectively. This result suggests that EOs are promising antibacterial agents given their weak toxic effects on normal cell lines at low concentrations.
Awareness and Utilization Pattern of Unani Medicine in India: A Systematic Review
Authors: Ali Khan Asim , Anant Awasthi Aanchal , Saeed Shazina , Parveen Shagufta , Kishore Jugal , Janardhanan Rajiv , Selvamurthy W
Published: December 2022

Unani medicine is one of the traditional medical systems in India that is practiced and taught in an organized manner. While going through the literature, it has been observed that in the past, not many efforts have been made to understand the awareness level and utilization pattern among the population. This systematic review was conducted to better understand the awareness and utilization pattern of Unani medicine in India. Using the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guideline, the results of survey-based studies conducted about the awareness and utilization pattern of Unani medicine in India were systematically reviewed. Thirteen studies conducted on awareness or utilization patterns, which exclusively represented data on Unani medicine and not Ayurveda, Yoga, Naturopathy, Unani, Siddha and Homeopathy (AYUSH) in general, were included in the present systematic review. A wide variation regarding awareness of Unani medicine is observed, ranging from 28.9% to 100% in different populations. Only five studies reported utilization patterns, which also varied considerably (13.8% to 74%). Unani Medicine is generally used in musculoskeletal disorders (20%-60.2%) and skin disorders (21.1%-64.9%). On the other hand, fifty-seven papers on surveys of CAM and AYUSH were found regarding utilization and consumption patterns. The findings demonstrate that thirteen papers entirely focused on the Unani System of Medicine. Henceforth, the awareness of the Unani system of Medicine has not been reported among the masses, and to provide its maximum benefits, certain strategies need to be formulated.
HEPATOPROTECTIVE EFFICACY OF THE MINEROL AND LEQUIN COMPLEX IN RATS WITH CHRONIC CHOLESTASIS
Authors: Makarenko О. А. , Mogilevska T. V. , Borisenko L. N.
Published: December 2022

Problem: experimental substantiation of the prevention of disorders in the hepatobiliary system in chronic cholestasis in rats with the Minerol and Lequin complex.
Aim: to study the hepatoprotective properties of the Minerol and Lequin complex in rats with cholestatic liver damage.
Methods. The study was carried out on male rats of herd breeding. The animals were divided into 3 groups: group 1 – control, group 2 – animals with simulated cholestasis by ligation of the common bile duct, group 3 – animals that were subjected to prophylaxis against the background of cholestasis (administered the drugs Minerol and Lequin orally in the morning on an empty stomach for 4 months). The activity of alkaline phosphatase, alanine aminotransferase, elastase, the concentration of calcium, triglycerides and cholesterol were determined in the raw blood. The state of the liver was assessed by the organ index and the level of biochemical indicators of inflammation (MDA content, activity of urease, elastase, acid phosphatase and catalase).
Main results. Experimental modeling of cholestasis in rats disrupted the functional state of the liver of animals, which was accompanied with a disturbance of lipid metabolism, an increased activity of markers of inflammation and intoxication both in the liver and in the raw blood, an increase in the organ index of the liver and a disturbance of the antioxidant-prooxidant system. Daily administration of the complex of drugs Minerol and Lequin to animals significantly improved the condition of the liver, providing hepatoprotective, antioxidant and anti-inflammatory effects.
Conclusions: the obtained results of the study established the high hepatoprotective effectiveness of the complex of drugs Minerol and Lequin, on the basis of which they make it possible for us to recommend it to patients with cholestasis problems as a prevention of disorders in the hepatobiliary system.
TROPHIC DIVERSITY OF LITTER NEMATODE COMMUNITIES OF FORESTS IN THE MEZIN NATIONAL NATURE PARK
Authors: Zhylina T. M. , Shevchenko V. L.
Published: December 2022

Introduction. Nematodes are one of the most abundant groups of the soil and litter fauna in forest ecosystems. The  faunal  composition  may  mirror  the  activity  of  decomposition  pathways  and  give indications of nutrient status and fertility of soil. Nematodes play an important role in regulating microbial communities and affect the speed and direction of mineralization and humification of plant precipitation.

Aim. Trophic structure of nematode communities from litter in forests of the Mezin National Nature Park was studied.

Materials and methods. Samples litter were collected from June to July 2010 and 2014 in 21 forest ecosystems. Nematodes were extracted by a modified Baermann’s method from the 5-g sample. The exposition time was 48 h. Extracted nematodes were fixed in the triethanolamine–formalin (TAF, 2 % triethanolamine, 7 % formaldehyde solution, 91% water), and mounted on the temporary hydroglyceric slides. Nematode abundance was expressed as specimens per 100 g of dry substrate.

Results. The 46 identified nematode species were divided into five trophic groups: saprobionts, mycohelminths, omnivores, predators and phytohelminths. Saprobionts were both the most diverse and the most numerous. 26 species (56,52% of all species collected) belonged to the this trophic group, proportion in the community was 63,97%. Plectus cirratus, Plectus parietinus, Panagrolaimus rigidus were the most numerous (proportion in the community 24,13%, 9,65% and 8,18% of the total, respectively). P. rigidus occurred in 95,2% of all samples. Aphelenchoides composticola dominated among 10 species of mycohelminths (frequency was 85,7%, proportion in the community 8,99%). Mesodorylaimus bastiani was common аmong the three species of omnivorous nematodes (frequency was 90,48%, proportion in the community 13,74%). Predatory nematodes (5 species) were in 57,1% of samples, proportion in the community together was 3,17%. Only two species phytohelminths (Gracilacus audriellus, Paratylenchus nanus) were found in the analyzed litter samples. They were rare; their frequency was 9,52% and 4,76% respectively. Moreover they were not very abundant (0,12% and 0,08% of total number respectively).

Conclusions. The mycohelminths and saprobionts make an important component of the litter decomposer community of all forest ecosystems in the Mezin National Nature Park. The ratio of mycohelminths to saprobionts (М/S) shows a constant preponderance of saprobionts and was 0,27. Twenty five species (54,35% of all species collected) were high colonization ability, high reproduction rate and high tolerance to disturbances. The trophic diversity index was 2,16. The maturity index was 2,27. These indexes show stability of habitat in the forest litter.
EDUCATIONAL TRADITIONS AS THE GROUND FOR GLOBAL VALUES AND NATIONAL MENTALITY
Authors: Strilchuk L.V.
Published: December 2022

Review of the book: Sinyavska O. O. History of education and science in Ukraine: education. manual / O. O. Sinyavska. – Odesa: Odesa. national I. I. Mechnikov University. – 2022. – Part 1: Traditions of education and accumulation of scientific knowledge in the pre-modern period. - 159 p.
The Effects of Mathematics Anxiety on Mathematics Performance among Secondary School Students in Tanzania: A Case of Arusha City Council
Authors: Salahot Ester  Damiano
Published: December 2022

The continuous trend of poor mathematics performance in Tanzania has developed different stakeholders' attention, including the Government, to research the possible causes of poor performance. The presence of mathematics anxiety among students is believed to have an impact on students' performance in Mathematics. In this study, the researcher aimed to investigate the effects of Mathematics Anxiety on Mathematics Performance Among Secondary Schools Students in Tanzania. The study employed a sample size of 396 students from six secondary schools in the Arusha City Council. The researcher collected data through structured questionnaires with closed-ended questions distributed to respondents. Respondents' mathematics terminal examination marks were used in this study. The collected data were analysed using descriptive (percentages and mean) and inferential statistics (correlation and multiple regression analysis). The results generally revealed a significant effect of mathematics anxiety on mathematics performance among secondary school students at a 0.05 level of significance (P-Value 0.00 2- tailed). A correlation coefficient r = 0.304 indicate a significant moderate positive relationship between the effects of mathematics anxiety and mathematics performance. The regression equation  indicates that mathematics anxiety affects mathematics performance by 46.6% when other factors remain constants. Based on the findings, it was recommended that mathematics teachers be aware of the possibility of mathematics anxiety among their students. Also, further studies that involve a large sample should be conducted to re-confirm the assertion.
Ege Bölgesi Fiğ (Vicia sativa L.) Islah Çalışmalarında Geçmişten Günümüze Gelişmeler
Authors: ÖZPINAR Hüseyin , AY Ergül , OKKAOĞLU Hülya , AKÇA PELEN Melek
Published: December 2022

Ege Bölgesinin ekolojik koşullarına ve tarla sistemine uygun, ot ve tohum verimi yüksek, kaliteli hastalıklara mukavim, tek yıllık bazı baklagil türlerini ıslah ederek çeşit geliştirmek amacı ile 1967 yılında başlatılan ‘Ege Bölgesi Yem Bitkileri Araştırmaları’ projesi kapsamında günümüze kadar 12 adet adi fiğ (Vicia sativa L.) çeşidi geliştirilmiştir. Türkiye’nin çeşitli yörelerinden toplanan yerel populasyonların değerlendirildiği çalışmada, saf hat seleksiyonu ve melezleme yöntemi kullanılmıştır. Çalışmanın ilk çıktısı, 1979 yılında tescil edilen Ürem 79 çeşidi olmuştur. Islah çalışmalarında önemli kavşaklardan ilki 1982 yılında erkenci ve daha kararlı bir çeşit olan, pamuk tarımında kışlık ara ürün olarak kullanılmaya çok elverişli Kubilay 82 çeşidinin geliştirilmesidir. İkincisi de yüksek hızlı dane doldurma özelliği ile öne çıkan erkenci, tohum verimi yüksek olan Selçuk 99 ve Cumhuriyet 99 çeşitlerinin tescil ettirilmesidir. Üçüncüsü ise yapılan melezleme çalışmaları neticesinde erkenci, kuru madde ve tohum verimleri yüksek, 2010 yılında tescil edilen Alper ile 2013 yılında tescil edilen Doruk ve Ürkmez çeşitlerinin sektöre kazandırılması ile olmuştur. Geliştirilen çeşitler, bölgemiz ve benzer iklim koşullarına uygunluğu ve yüksek verimleri ile önemli bir ekiliş alanına sahip olup sertifikalı tohumluk üretimine dolayısıyla ülke tohumculuğuna büyük katkı sağlamıştır.
DAS CRISES À BIOSFERA
Authors: Rocha Larissa Leda F. , Azambuja Patrícia , Costa Ramon Bezerra
Published: December 2022

Este trabalho reflete sobre limitações cognitivas e sensíveis para lidar com nossas experiências atuais ao nos apoiarmos em valores morais canônicos e desconectados das circunstâncias de vida coletiva. Ficções úteis preenchem as lacunas e justificam alternativas escolhidas como substitutas para nossos medos. Curiosamente, também aponta uma sedução culposa pelo horror, pelo monstruoso, ao lançarmos os olhos à história das sensibilidades do ver. Refletir sobre essas mudanças sensíveis e a forma como são articuladas pelo sistema midiático talvez ofereça soluções para crises causadas pelas instabilidades de um tempo confuso. Busca saídas epistêmicas para lidar com estes cenários e aponta a ecosofia como uma trilha para imaginarmos outra narrativa capaz de reorientar nossos relacionamentos conosco, com os outros e com os ecossistemas do entorno, a biosfera. Este trabalho realiza, ainda, uma reflexão teórica apoiada em pesquisa bibliográfica e observação empírica
OBSERVATÓRIO SOCIAL E DO TRABALHO NO MARANHÃO COMO INSTRUMENTO DE DEMOCRATIZAÇÃO
Authors: Silva Maria Ozanira da Silva e , Pereira Maria Eunice Ferreira Damasceno , Lima Valéria Ferreira Santos de Almada
Published: December 2022

Este artigo apresenta resultados do Projeto Observatório Social e do Trabalho no Maranhão, desenvolvido no âmbito do Grupo de Avaliação e Estudo da Pobreza e de Políticas Direcionadas à Pobreza (GAEPP), articulado ao Programa de Pós-Graduação em Políticas Públicas (PPGPP) da Universidade Federal do Maranhão (UFMA). O Observatório Social e do Trabalho objetiva promover a coordenação, a articulação e a divulgação dos estudos e pesquisas que configuram os seus dois eixos temáticos, Pobreza e Trabalho, tendo em vista subsidiar e capacitar sujeitos sociais para se apropriarem de informações necessárias aos processos de tomada de decisão e ao exercício do controle social de Políticas Públicas. O artigo está estruturado em três eixos: o primeiro apresenta a concepção e a dinâmica de funcionamento do Observatório Social e do Trabalho enquanto mecanismo de democratização e controle social das políticas públicas; o segundo e o terceiro abordam o aprofundamento, respectivamente, da precarização do trabalho e da pobreza, no Brasil e no Maranhão, no contexto pós golpe de 2016 e sobretudo durante a pandemia da COVID-19.
POLÍTICAS PÚBLICAS EM TEMPOS CONSERVADORES
Authors: Ramos Adriana , Guazzelli Amanda , Giustina Emilie Faedo Della , Camargo Janaína Albuquerque de
Published: December 2022

Este texto procura apresentar, de maneira meramente introdutória, uma discussão acerca das políticas públicas na contemporaneidade, assumindo como pressuposto de análise que sua efetivação se dá no cotidiano das classes sociais subalternas e conformada por traços conservadores. Compreende que é no cotidiano que se objetivam, em condições históricas e socialmente determinadas, as relações sociais entre os sujeitos e, portanto, entre as classes – entre os subalternos, grupos sociais constituídos que estão sujeitos a formas de direção política e social impostas pelas classes dominantes. Conclui que essa luta se expressa no cotidiano, que é carregado de determinações históricas e sociais, espaço para a conquista da hegemonia, de um determinado grupo sobre o outro, onde se constrói e se consolida a ordem instituída, mas também onde a ela se resiste.
Estresse e resiliência na rotina do profissional da saúde
Authors: Iarrocheski Larissa Zucco , Batista Fernanda Cristina Neidert , Perrelli Marly
Published: December 2022

A saúde mental na contemporaneidade é um tema de destaque, repercutindo de nas discussões acadêmicas e midiáticas, mostrando sua importância e relevância, bem como o impacto na vida de todos os sujeitos. A justificativa se encontra uma vez que analisado o contexto emocional desses trabalhadores e suas rotinas, pois essas exigem preparo técnico e psicológico, além de competência para administrar suas emoções e sentimentos aliados ao dia a dia hospitalar e de emergências que envolvem tensões constantes. O artigo buscou responder à pergunta de quais os mecanismos que os profissionais da saúde utilizam como forma de enfrentamento das condições adversas do dia a dia para manter a sua saúde mental? A metodologia do presente trabalho teve como objetivo é compreender sobre esta temática da resiliência na saúde através de análise dos materiais publicados nas bibliotecas virtuais na área da saúde, utilizando como descritores: resiliência, profissional da saúde, estresse, ambiente hospitalar. Através das discussões encontradas foi possível evidenciar que o estresse no ambiente de trabalho, junto com as tensões da rotina de urgência e emergência podem desencadear problemas emocionais e psicológicos, bem como doenças psicossomáticas. Conclui-se, portanto, que a resiliência é uma habilidade, tanto quanto um recurso humano para o bom desenvolvimento e manutenção da saúde mental do profissional da saúde.
A consumação da decadência na contemporaneidade
Authors: Silva Flávio de Oliveira
Published: December 2022

Este artigo traz, inicialmente, uma compilação dos resultados de análises e reflexões das pesquisas que realizamos acerca do tema da decadência (Verfallen), a partir do pensamento do filósofo alemão Martin Heidegger. Apresentamos esse conceito como questão fundamental para a superação da metafísica na concepção heideggeriana, destacamos os antecedentes históricos que teriam conduzido Heidegger a gestar o conceito de decadência; o registro do surgimento desse conceito na sua filosofia e, por fim, fazemos um recorte de passagens fundamentais da filosofia e das ciências, a fim de caracterizar a consumação da decadência na contemporaneidade.
CONTORNANDO A TRADIÇÃO: o papel geofilosófico 'menor' do Brasil (e da América Latina)
Authors: Maia Leonardo
Published: December 2022

A perspectiva de uma crítica contemporânea à ‘tradição filosófica’ parece se vincular, em particular, ao quadro histórico-filosófico que se desenha a partir do final da Segunda Grande Guerra, e que irá refletir uma especial preocupação do pensamento com o fenômeno do nazifascismo. Há uma importante confluência de autores e autoras no intuito de deslindar os sentidos trágicos dessa experiência, que se mostrara devastadora sob vários aspectos. No bojo dessa orientação genericamente anti-fascista ou pós-fascista, começa a se configurar um movimento crítico mais agudo que afinal irá mirar a própria centralidade europeia na determinação da investigação filosófica. Essa investida, que ainda estaria em curso, se evidenciaria segundo ao menos três perspectivas: a da revisão do sentido da racionalidade tipicamente europeia, de um novo dinamismo menor do pensamento, através da valorização das situações e condições minoritárias e a da recusa da hierarquização epistêmica eurocentrada em favor de uma outra mundialização da Filosofia, em busca de novas configurações epistêmicas periféricas. Que papel o Brasil e a América Latina teriam em tal cenário geofilosófico? As formulações de Darcy Ribeiro, autor que não exatamente se inclui no campo filosófico, parecem conferir alguma resposta a esse tema.
REPENSAR AS INSTITUIÇÕES PARA DEFESA DOS BENS COMUNS EM TEMPOS DE CRISES SOCIOAMBIENTAIS
Authors: Losekann Cristiana
Published: December 2022

Apresentação do Dossiê Os Bens Comuns: Debates e ameaças no atual contexto nacional e internacional
Share Repurchases Versus Dividends: A Comparison Between Poland And South Africa
Authors: Kaźmierska-Jóźwiak Bogna , Wesson Nicolene , Steenkamp Gretha
Published: December 2022

The main aim of the study is to compare share repurchase and dividend payout trends of listed non-financial and non-resource companies in Poland and South Africa over the period 2005–2015. Although South Africa is a developing country with a dualistic economy, the country is characterized by a sophisticated stock exchange which is comparable to that of most advanced economies, while Poland was reclassified from emerging market to developed market status, effective as from 24 September 2018. Comparative analysis provides insights on the regulatory differences and the effect therefore on share repurchase and dividend behaviour, and whether these countries mirror the excessive payout behaviour observed in the United States of America (US). The study results show that in both countries dividends are the dominant form of payouts to shareholders. Moreover none of the examined countries mirrors the excessive payout behaviour observed in the US ­­– neither in Poland, nor in South Africa did share repurchases surpass dividends. Regulatory differences between Poland and South Africa, however, affected the observed trends in payout behaviour between the two countries.
How Have Saharan Breeder Been Able to Secure Food for Their Herds During the Containment of COVID-19? Case of Oued Souf, Algeria
Authors: Lakhdari K. , Boussaada T. , Benatallah S.A. , Bouhanna M. , Laouisset M.S.
Published: December 2022

Background: In Algeria, COVID-19 containment procedures 2020-2021 have put the livestock sector in a critical situation, particularly in the Saharan regions where animal feed is based on supplies from other regions. Indeed, a famine has threatened the herds, but the breeders have been able to save their animals by an unconventional diet. The knowledge of these nutritional measures and know-how makes it possibleto evaluate local products andto guide Algerian decision-makers towards a safer food strategy that is well adapted to the Sahara region. Methods: We used the “12MO method”, which is a retrospective survey based on the declarations of the breeders for the last twelve months. 12MO served as a basic tool for a systemic analysis conducted in 110 farms in different areas of Oued Souf (Sahara of Algeria). Result: The results highlighted changes in animal feed, under the impact of COVID-19 pandemic through unconventional feeding. 6 feeds were distinguished, including 4 crop residues (PoCR; PeCR; CCR ; TCR) and 2 by-products (PD By-P; PD By-P). During a year of containment, it was not only the interrelationship (agriculture/livestock) that has secured the feeding herds in the Saharan environment, but the breeder’s solidarity has significantly contributed in that also.