bluuebunny/crossref_metadata_2025 huggingface dataset:
Protocol for the unclassified primary antibody deficiency (unPAD) study: Characterization and classification of patients using the ESID online Registry
Authors: Janssen Lisanne M. A. , Reijnen Ineke C. G. M. , Milito Cinzia , Edgar David , Chapel Helen , de Vries Esther ,   the unPAD consortium
Published: March 2022

Background

Primary antibody deficiencies (PADs) without an identified monogenetic origin form the largest and most heterogeneous group of primary immunodeficiencies. These patients often remain undiagnosed for years and many present to medical attention in adulthood after several infections risking structural complications. Not much is known about their treatment, comorbidities, or prognosis, nor whether the various immunological forms (decreased total IgG, IgG subclass(es), IgM, IgA, specific antibody responses, alone or in combination(s)) should be considered as separate, clearly definable subgroups. The unclassified primary antibody deficiency (unPAD) study aims to describe in detail all PAD patients without an identified specific monogenetic defect regarding their demographical, clinical, and immunological characteristics at presentation and during follow-up. In constructing these patterns, the unPAD study aims to reduce the number of missed and unidentified PAD patients in the future. In addition, this study will focus on subclassifying unPAD to support the identification of patients at higher risk for infection or immune dysregulation related complications, enabling the development of personalized follow-up and treatment plans.

Methods and analysis

We present a protocol for a multicenter observational cohort study using the ESID online Registry. Patients of all ages who have given informed consent for participation in the ESID online Registry and fulfill the ESID Clinical Working Definitions for ‘unclassified antibody deficiency’, ‘deficiency of specific IgG’, ‘IgA with IgG subclass deficiency’, ‘isolated IgG subclass deficiency’, ‘selective IgM deficiency’, ‘selective IgA deficiency’ or ‘common variable immunodeficiency’ will be included. For all patients, basic characteristics can be registered at first registration and yearly thereafter in level 1 forms. Detailed characteristics of the patients can be registered in level 2 forms. Consecutive follow-up forms can be added indefinitely. To ensure the quality of the collected data, all data will be fully monitored before they are exported from the ESID online Registry for analysis. Outcomes will be the clinical and immunological characteristics of unPAD at presentation and during follow-up. Subgroup analyses will be made based on demographical, clinical and immunological characteristics.
Early hip laxity screening and later canine hip dysplasia development
Authors: Santana Ana , Alves-Pimenta Sofia , Franco-Gonçalo Pedro , Gonçalves Lio , Martins João , Colaço Bruno , Ginja Mário
Published: March 2022

Background and Aim: Passive hip laxity (PHL) is considered the primary risk factor for canine hip dysplasia (HD) and is estimated, in stress hip radiographs, using the distraction index (DI). The study aimed to associate the early PHL using the hip Distractor of University of Trás-os-Montes and Alto Douro (DisUTAD) and the late HD grades. Materials and Methods: A total of 41 dogs (82 hips) were submitted to a follow-up study. First, between 4 and 12 months of age, dogs were radiographed using the DisUTAD hip distractor and were determined the DI for each hip joint. Then, after 12 months of age, dogs were reevaluated for HD using the conventional hip ventrodorsal projection and hips were evaluated for HD using the Fédération Cynologique Internationale (FCI) scoring system. Results: Hips of dogs' in the second examination with FCI grades of A (n=28), B (n=11), C (n=22), and D and E (n=21) had an early DI of 0.32±0.1, 0.38±0.08, 0.50±0.12, and 0.64±0.11, respectively. Statistical analysis using the general linear model univariate, with the DI as dependent variable and the FCI grades, side and sex as fixed factors, and the post hoc Bonferroni correction test showed significant differences among FCI grades (p<0.05). Conclusion: These results show the association between early DI and the late FCI HD grades and the DisUTAD is recommended for the early canine HD diagnosis.
The application of ascorbic acid as a therapeutic feed additive to boost immunity and antioxidant activity of poultry in heat stress environment
Authors: Hieu Truong Van , Guntoro Budi , Qui Nguyen Hoang , Quyen Nguyen Thi Kim , Al Hafiz Farid Akbar
Published: March 2022

Ascorbic acid, widely known as vtamin C, is an essential nutrient for animals such as poultry. Ascorbic acid in poultry feed improves animal health and thus increases the growth performance of birds. Ascorbic acid can be used in the form of synthetic products or can be naturally obtained from fruits and plants. It is soluble in water and can be easily administered in drinking water and the diet. Poultry can synthesize ascorbic acid in the body. However, the performance of the animals can be improved by adding ascorbic acid to their diet. In addition, ascorbic acid is called an antioxidant and an anti-inflammatory. This increases their resistance to disease during the transition season. Ascorbic acid supplementation positively affects the stress response, especially during the dry season in tropical countries. Furthermore, supplementing ascorbic acid in the poultry's diet improves resistance to diseases, regulates stress, and helps in the body's oxidation process. Ultimately, this enhances the laying rate, egg hatch performance, and higher poultry productivity. For layers at the end of the laying period, it helps increase the quality of the eggshell and reduces the proportion of broken eggs. Ascorbic acid has a strong relationship with other vitamins such as vitamin E and other substances such as zinc, safflower oil, folic acid, and a fibrous diet. This review aims to synthesize all the information of ascorbic acid in the poultry's diet, thereby providing the general role of ascorbic acid for the poultry industry.
Effect of heat stress on vital and hematobiochemical parameters of healthy dogs
Authors: Azeez Oyebisi Mistura , Olaifa Folashade Helen , Adah Adakole Sylvanus , Basiru Afisu , Akorede Ganiu Jimoh , Ambali Hauwa Moturayo , Suleiman Kolawole Yusuf , Sanusi Fatima , Bolaji Mashood
Published: March 2022

Background and Aim: Heat stress is a major challenge for animals, impairing their welfare and performance. This study aimed to determine the effect of heat stress on the vital and hematobiochemical parameters of healthy dogs.

Materials and Methods: The experimental subjects comprised 10 dogs, encompassing seven males and three non-pregnant females between 2 and 3 years of age. Ambient temperature (AT) and relative humidity (RH) were recorded 2 hourly during the day and the temperature humidity index was calculated. Vital parameters [i.e., rectal temperature (RT), respiratory rate, and heart rate (HR)] were assessed and blood was collected from each dog daily for hematobiochemical analysis.

Results: The RT (38.5±0.2°C) of dogs exposed to high AT and high RH (HA/HR) conditions was significantly (p<0.05) higher than that of dogs exposed to HA and low RH (LR) conditions (37.2±0.11°C). Under HA/HR conditions, packed cell volume, hemoglobin concentrations, and white blood cell counts were significantly lower than those of the same dogs exposed to HA/LR conditions. Conversely, under HA/HR conditions, the lymphocyte, monocyte, eosinophil, alanine aminotransferase, aspartate aminotransferase, and cortisol values were significantly higher (p<0.05) than the values obtained in dogs exposed to HA/LR conditions. Meanwhile, the alkaline phosphatase, urea, and glucose levels were significantly lower (p<0.05) in dogs exposed to HA/HR conditions.

Conclusion: The exposure of healthy dogs to HA/HR conditions induced heat stress, which may have an adverse effect on their immune status, thereby affecting their health and welfare.
Floodplain aggradation caused by the high magnitude flood of 2006 in the lower Tisza region, Hungary
Authors: Sándor Andrea , Kiss Tímea
Published: March 2022

The area of floodplains in the Carpathian Basin was dramatically reduced as a result of river regulation works in the 19th century. Therefore, the accumulation processes were limited to the narrower floodplains. The aims of the presented study are to determine the rate of accumulation caused by a single flood event on the active, narrow floodplain of the Lower Tisza and to evaluate the relations between the aggradation, flow velocity during the peak of the flood and the canopy. The uncultivated lands in the study area cause increased roughness which decreased the velocity of the flood, influencing the rate of aggradation. The highest flow velocity was measured on points where the flood entered to the floodplain and at the foot of the levee. These points were characterised by thick (over 50 mm) and coarse sandy sediment. In the inner parts of the floodplain flood conductivity zones were formed, where the vegetational roughness was small. In the inner parts of the floodplain the rate of aggradation was influenced by the geomorphology and the vegetation density of the area.
L’incarnation de l’âme
Authors: Soual Philippe
Published: March 2022

This article questions the union of soul and body, seeing in them not two separate things to be in relation, but one and the same unit capable of differentiating itself by articulating its powers: a life of the spiritual soul. who is fulfilled, who is embodied in his carnal life. This can be seen if we consider the ages of life: this union is a singular story, with its rhythm and its aporias. This is the story of a gradual unification of oneself within one's body. This is verified in the life of the mature soul, where it manifests itself in its fleshly body; and in the hierarchical unity of spiritual powers, for the human soul is itself only insofar as an intellect informs its intimate and carnal life, in the unity of its breath, so that the sensitivity, imagination, memory and will are the manifestations of the intellect in the soul and in its personal body.
A racionalitás végvárai. A számszerűsítés megjelenítése az üzleti döntésekben
Authors: Farkas-Kis Máté
Published: March 2022

Az utóbbi évtizedekben a gazdasági, döntéselméleti és matematikaoktatási tudományterületek egymás mellett, de egymástól függetlenül fejlődtek. Miközben mind jelentős előrelépést ért el, közös területeik kevésbé voltak a tudományos kutatások középpontjában. A szerző célja az, hogy összefoglalja a legfontosabb mérföldköveket és azokon keresztül bemutassa, hogyan alakult ki a számszerűsítés és milyen hatást fejtett ki a felsorolt tudományterületeken. Miként lett a gazdasági folyamatok fő meghatározója, a döntéseket befolyásoló, az oktatásban központi szerepet játszó szimbólumrendszer? Miként vált a racionalitás letéteményesévé és ad lehetőséget éppen emiatt a figyelmetlen döntéshozó elme megtévesztésére? Végül, de nem utolsó sorban, épp e tulajdonsága miatt, hogyan képes a számszerűsítés közvetíteni az érzelmi és racionális döntéseink között, adott esetben azokat egymásba átvinni?
Imaging of the Pancreas (IMAP) in New-Onset Diabetes (NOD): A Prospective Pilot Study
Authors: BU Wu , E Lustigova , Q Chen , EY Dong , A Maitra , ST Chari , Z Feng , JA Rinaudo , LM Matrisian , RA Parker
Published: March 2022

Background:

The aim of this study was to assess the feasibility of cross-sectional imaging for detection of pancreatic cancer in patients with NOD.

Methods:

We conducted a prospective pilot study from 11/2018-3/2020 within an integrated health system. Patients 50-85 years with newly elevated glycemic parameters without prior history of diabetes were invited to complete a three-phase contrast-enhanced computed tomography pancreas-protocol scan while participating in the Prospective Study to Establish a New-Onset Hyperglycemia and Diabetes (NOD) Cohort. Abnormal pancreatic findings, incidental extra-pancreatic findings, as well as subsequent clinical evaluation were identified. Variability in clinical reporting between medical centers based on descriptors of pancreatic duct and parenchyma was assessed.

Results:

A total of 130 of 147 (88.4%) participants consented to imaging; 93 scans were completed (prior to COVID-19 stay-at-home order). Median age was 62.4 years (IQR 56.3, 68.8), 37.6% female; Hispanic (39.8%), White (29.0%), Black (14.0%), and Asian (13.3%). One (1.1%) case of pancreatic cancer (stage IV) was diagnosed, 12/93 (12.9%) participants had additional pancreatic findings: 5 fatty infiltration, 3 cysts, 2 atrophy, 1 divisum, 1 calcification. There were 57 extra-pancreatic findings among 52/93 (56%) unique patients, 12/57 (21.1%) prompted clinical evaluation with 2 additional malignancies diagnosed (non-small cell lung, renal oncocytoma). Reports from one participating medical center more frequently provided description of pancreatic parenchyma and ducts (92.9% vs. 18.4%), P<0.0001.

Conclusion:

High proportion of incidental findings as well as variability in clinical reports are challenges to be addressed for a successful NOD-based early detection strategy for pancreatic cancer.
Impressos estudantis secundaristas como fonte para a História da Educação: potencialidades e desafios no processo de produção de um repertório sobre o Sul de Mato Grosso (Brasil)
Authors: Moreira Kênia Hilda , Galvão Ana Maria de Oliveira
Published: March 2022

Apresenta reflexões metodológicas decorrentes da experiência de repertoriar a imprensa periódica estudantil, como fonte potencial de pesquisas para a História da Educação, a partir dos procedimentos de localização e da análise de 10 impressos estudantis de nível secundário, produzidos no sul de Mato Grosso, entre 1934 a 1998. A análise dos elementos materiais de produção permitiu algumas conjecturas interpretativas sobre o repertório em questão. Como categorias temáticas levantamos: Cultura estudantil; instituição escolar secundária; feminismo/mulher; e cinema e educação, cientes de que os impressos, como fonte, permitem muitas outras. O largo tempo que abrange esse repertório apresenta a vantagem de poder investigar as mudanças e as permanências em torno da produção e das temáticas elencadas nos referidos impressos.
Variasi Morfometri dan Patogenisitas Peronosclerospora spp. Penyebab Penyakit Bulai Jagung di Pulau Jawa, Indonesia
Authors: Adhi Satriyo Restu , Widiantini Fitri , Yulia Endah
Published: March 2022

Kehilangan hasil akibat penyakit bulai, yang disebabkan oleh Peronosclerospora spp. di beberapa sentra penanaman jagung di Pulau Jawa telah dilaporkan. Penelitian dilakukan untuk menentukan karakteristik morfometri dan tingkat patogenisitas strain Peronosclerospora. Sepuluh strain Peronosclerospora spp. berasal dari sentra produksi jagung, yaitu Blitar (BLT), Kediri (KDR), Kediri 2 (KDR2), Klaten (KLT), Cianjur (CJR), Garut (GRT), Jatinangor Sumedang (JTN), Rancakalong Sumedang (RCG), Indramayu (IMY), dan Sukabumi (SKB). Variasi morfometri diperoleh melalui pengamatan secara mikroskopis dengan melihat bentuk konidium, mengukur ketebalan dinding sel, panjang konidiofor, konidium dan konidiofor, serta menghitung jumlah cabang dan percabangan. Tingkat patogenisitas ditetapkan dengan cara menghitung persentase insidensi penyakit pada tanaman jagung. Hasil penelitian menunjukkan morfometri dan tingkat patogenisitas strain yang beragam. Analisis dendrogram berdasarkan karakter morfometri memisahkan strain Peronosclerospora menjadi dua klaster utama. Strain KDR2 merupakan spesies P. philipinensis karena identik dengan strain rujukan, yaitu P. philippinensis yang berada pada satu klaster; sedangkan strain-strain lain teridentifikasi sebagai P. maydis karena identik dengan spesies rujukan P. maydis dan membentuk satu klaster lain. Berdasarkan uji patogenisitas, strain IMY menyebabkan insidensi penyakit terendah (8.33%) dan strain KLT menyebabkan insidensi penyakit tertinggi (47.92%).
On the Spectrum of an Operator Associated with Least-Squares Finite Elements for Linear Elasticity
Authors: Alzaben Linda , Bertrand Fleurianne , Boffi Daniele
Published: March 2022

In this paper we provide some more details on the numerical analysis and we
present some enlightening numerical results related to the spectrum of a
finite element least-squares approximation of the linear elasticity
formulation introduced recently. We show that, although the formulation is
robust in the incompressible limit for the source problem, its spectrum is
strongly dependent on the Lamé parameters and on the underlying mesh.
Experimental study of the behaviour and failure modes of tapered castellated steel beams
Authors: Al-Thabhawee Hayder Wafi , Al-Kannoon Muslim Abdul-Ameer
Published: March 2022

This article discusses the experimental testing of tapered castellated beams (TCBs) under mid-span concentrated load. These beams are created by cutting the webs of standard I-sections in a particular zigzag pattern and rejoining the two parts by placing variable expansion plates between web posts and welding them together. Generally, the depth of the mid-span will be increased. A standard I-section (IPE140) was selected as a parent beam to fabricate three TCB specimens and one prismatic castellated beam. The experimental results showed that the ultimate load capacity of the TCBs could be increased up to 140% of the ultimate load capacity of the parent section. Fabricating a TCB is an effective way of increasing the allowable load of a long-span member while remaining within International Building Code-defined deflection limits. The experimental results showed that the allowable load at deflection (L/360) increased up to 183% of the allowable load for the control specimen at the same deflection. Finally, the experimental results showed that web-post buckling and joint-weld rupture failure modes occurred in TCBs due to the formation of high shear forces that tried to twist the web posts.
The combined effects of ripening degree and fermentation process on biochemical properties of table olives and oils of Ayvalık and Gemlik varieties
Authors: Uslu Nurhan , Özcan M. Musa
Published: March 2022

The purpose of this study was to investigate the effect of variety, ripening degree, and also fermentation process on the bioactive compounds of olives, and on the fatty acid compositions of olive oils. The highest oil content was determined in fermented green olives (70.02% in Gemlik variety; 66.87% in Ayvalık variety). The fermentation process caused a notable reduction in both total phenolic content (from 2558.30–2894.40 to 699.10–1087.00 mg/kg), and antioxidant activity values (from 81.46–81.20 to 26.00–63.75%) of green olives in brine. Verbascoside was identified as the main phenolic compound (1150.95–1311.25 mg/kg). It was observed that oleuropein, hydroxytyrosol, tyrosol, and rutin contents of olives decreased after fermentation process. Concerning the fatty acid compositions of olive oils, oleic (70.13–75.47% for Gemlik; 67.36–70.22% for Ayvalık) and linoleic acid (6.18–11.13% for Gemlik; 10.13–12.94% for Ayvalık) contents showed differences regarding variety and maturation degree. However, there are minor variations in fatty acid composition according to fermentation.
The main probability G-density of the theory of non-Hermitian random matrices, VICTORIA transform, RESPECT and REFORM methods
Authors: Girko Vyacheslav L.
Published: March 2022

The main probability G-density of the global law for random matrices
whose entries are independent is founded.
The G-pencil law under G-Lindeberg condition.
The canonical equation K_98 and G-logarithmic law
Authors: Girko Vyacheslav L. , Shevchuk B. V. , Shevchuk L. D.
Published: March 2022

The examples of the pencil law for two random matrices whose pairs of entries are independent are considered.
Quantum transport and microwave scattering on fractal lattices
Authors: Subramaniam Krishnasamy , Zschornak Matthias , Gemming Sibylle
Published: March 2022

Studying the wave-particle nature of electrons in different ways has lead to many fundamental discoveries. Particularly, the dimensionality dependent electronic behavior in the Luttinger Liquid (1D), Quantum Hall (2D) and non-interacting Fermi Liquid (3D) regimes have already revolutionized our understanding of the mechanisms behind quantum electronics. In this work, the theoretical and experimental studies focus on the non-integer dimension represented by an sp2-carbon-based Sierpinski triangular structure with a 1.58D space occupancy. In the tight-binding approach, the spectral distribution of electronic states of such a structure exhibits distinct peak patterns, which are well-separated by gaps. Through quantum transport simulation, the conductance of electrons in 1.58D was studied. Both delocalized, conducting and localized, non-conducting states identified, which differ from the established features of both the fully 2D graphene sheet and 1D carbon nanotubes. In microwave scattering measurements on an adequate experimental setting and the respective simulations on the Sierpinski triangle, the obtained diffraction patterns showed interesting peculiarities such as a reduced number of minima and magic angle, next to diffraction regions of high and low intensity, as well as forbidden regions. The fractal geometry of the structure affects the propagation of waves by manipulating the way they interact with each other which results in structural metamaterial-like interference characteristics, decreasing or amplifying the transmitted or reflected signals, or blocking the transport completely.
Innovative Räumtechnik
Authors: Krazer Manfred
Published: March 2022

Obwohl die Entwicklung der Räumtechnik als technisch abgeschlossen gilt, gibt es auch in dieser Branche immer wieder Techniker und Ingenieure, die innovative Weiterentwicklungen betreiben. Neben den hohen Anforderungen an Produktqualität, der Verfügbarkeit und den reduzierten Aufstellflächen für Maschinen und Anlagen steht dabei die Orientierung an den Bedürfnissen und Wünschen des Kunden im Vordergrund. Die nachfolgenden Betrachtungen geben zunächst grundsätzliche Ausführungen zu diesem Verfahren, zeigen aber auch den Trend zu anwenderorientierten Lösungen.
Kooperation nach fraktalen Prinzipien
Authors: Kühnle Herrmann , Schnauffer Hans-Georg , Brehmer Nick
Published: March 2022

Obwohl die Potentiale vorhanden sind, wagen viele Unternehmen den Schritt in eine Kooperation nicht. Oft werden nur die Risiken in den Vordergrund gestellt, obwohl im eigenen Hause oft schon positive Erfahrungen gesammelt wurden. Wenn Kooperationen mit anderen Unternehmen in ähnlicher Form aufgebaut und durchgeführt werden, wie innerhalb eines fraktal strukturierten Unternehmens, lassen sich nachhaltige Erfolge erzielen.
The Influence of an 8-Week Strength and Corrective Exercise Intervention on the Overhead Deep Squat and Golf Swing Kinematics
Authors: Langdown Ben L. , Bridge Matt W. , Li Francois-Xavier
Published: March 2022

Langdown, BL, Bridge, MW, and Li, F-X. The influence of an 8-week strength and corrective exercise intervention on the overhead deep squat and golf swing kinematics. J Strength Cond Res 37(2): 291–297, 2023—It has previously been suggested that performance of the overhead squat (OHS) is a useful predictor of loss of posture in the golf swing. Using an 8-week intervention to improve OHS performance, this study assessed this suggestion and analyzed the impact of any resultant physical adaptations on golf swing kinematics. Thirty-seven golfers (handicap = 14.8 ± 13.3) were randomly split into a control group (n = 16) and an intervention group (n = 21)—who completed an 8-week strength and flexibility program. Pre- and postintervention OHS assessments and 3-dimensional (3D) 6-iron swing kinematics were captured. The level of significance set for the study was p < 0.05. Despite the intervention group's significant improvement in OHS thigh angle (p < 0.001), there were no significant changes in 3D swing kinematics between the groups and over pre- and posttesting for address (p = 0.219), top of the backswing (p = 0.977), and impact (p = 0.994). In addition, regression analysis revealed that the 4 measured OHS variables were significant and small predictors of swing kinematic variables at the top of backswing and impact (ranging from R
2 = 0.109 to R
2 = 0.300). These may, however, be spurious relationships as swing changes could be expected following the intervention if they were indeed true predictors of the postural variables. The use of the OHS to understand the cause of loss of posture during the golf swing is therefore not recommended because many other variables could influence swing kinematics. It may, however, be a useful assessment tool for strength and range of movement, provided that any motor learning issues are resolved before results influencing conditioning programs.
EDUCAÇÃO NA PANDEMIA: MEDIDAS TOMADAS NO ESTADO DA PARAÍBA
Authors: Fernandes Werona De Oliveira Barbosa , Patrício Waléria Quirino , Patrício Neujanny Chaves
Published: March 2022

No final de 2019 o mundo começa a tomar conhecimento de uma nova doença viral, a COVID-19. Diversas medidas são tomadas pelos países para conter o avanço da doença e minimizar os danos causados, sendo o isolamento social a medida mais utilizada até o presente momento. Tal medida preconizou o ensino de forma assíncrona ou remota, forçando os governos municipais, estaduais e federais a tomarem providências quanto à adaptação ao novo modelo educacional. Dessa forma, este trabalho teve como objetivo discutir as medidas tomadas no Brasil e, particularmente, no estado da Paraíba, para adaptação a nova modalidade de ensino. Apesar das novas medidas serem essenciais para diminuir a disseminação do vírus, existem consequências em diversas áreas, mas principalmente na educação. Para tanto, diversos governos vem elaborando planos que envolvem a utilização de Tecnologias de Informação e Comunicação (TIC) e do Ensino a Distância (EaD) como forma de minimizar os impactos causados na população estudantil.
CERVEJARIAS ARTESANAIS
Authors: Kohls Matheus , Da Silva Rehling Junior Marcos Fernando , Schwanz Dener , Soares Pereira Aline
Published: March 2022

Este artigo tem como propósito apresentar possíveis alternativas para impulsionar o mercado das cervejarias artesanais da cidade de Pelotas/RS, identificando os impactos causados a partir da pandemia do covid-19 no setor. Para isso, realizou-se uma pesquisa de forma exploratória e qualitativa, utilizando como suporte o embasamento teórico de autores conceituados no assunto. Esta pesquisa foi aplicada em conjunto aos gestores e realizada de forma on-line onde pode-se analisar de maneira coesa o atual momento vivenciado pelas empresas. Tão logo foram obtidos os resultados da pesquisa junto aos gestores, pode-se evidenciar as principais causas pelas quais as empresas vêm sendo impactadas durante o período de pandemia, dentre elas, destaca-se, a baixa demanda e uma piora significativa no setor de vendas. Tais desafios tem feito com que os gestores tentem reduzir os gastos e optem por alternativas inovadoras, novos produtos, e processos que se encaixem ao atual momento vivenciado pelo setor. A pesquisa demonstrou que a melhor alternativa buscada pelas empresas para divulgar e vender os seus produtos têm sido as redes sociais; também, que a implementação de um sistema próprio de entrega tem ajudado a atender aos clientes que tem evitado sair de casa ou que costumavam consumir os produtos fora mas não puderam fazer isso devido às medidas restritiva provocadas pela pandemia.
NEOEXTRACTIVISMO DE ORO A TRAVÉS DE LA ACUMULACIÓN POR DESPOJO EN LA GEOGRAFÍA DE MÉXICO EN EL SIGLO XXI
Authors: Merchand Rojas Marco Antonio
Published: March 2022

El objetivo consiste en analizar la estrategia de acumulación por desposesión y/o despojo que se traduce en garantizar ganancias exponenciales a los capitales extranjeros canadienses en la minería de cielo abierto para extraer el apreciado oro. Si se cubre con las expectativas de las inversiones extranjeras, se cumple así, con los dictados de la “Nueva División Internacional de Trabajo” fundamentado en la configuración de cadenas globales. El rasgo económico-político que definiría, dicha acumulación por desposesión, es que su instrumentación para llevarse a cabo, necesita obligatoriamente que el Estado y los dueños de capital minero tengan el interés común “contubernio”. Al concepto de despojo, hay que incluir, el concepto de globalización neoliberal que articula nuevas modalidades de generación y apropiación de riqueza y que caracteriza al neoextactivismo en sus rasgos específicos, consistente primero; en configurar cadenas globales de producción que permita ampliar la frontera extractivista (commodities) y segundo, se incurre en privatizaciones de medios de producción y sectores económicos estratégicos más favorables para las diversas fases de producción globalizada, incluyendo y garantizando una mano de obra barata y precarizada, ambiente institucional favorable (id est, bajos impuestos), condiciones reguladoras (id est, leyes laborales y ambientales más flexibles o hechas a modo para las cadenas globales (transnacionales).
OTIMIZAÇÃO DE HABILIDADES DIGITAIS PARA PROFESSORES E COLABORADORES DA ADMINISTRAÇÃO TRIBUTÁRIA DO PERU, APLICÁVEL NA FORMAÇÃO TÉCNICA TRIBUTÁRIA E ADUANEIRA E EM SEU TRABALHO DE SERVIÇO AOS CIDADÃOS DO PERU
Authors: Prieto Bacigalupo Regina Mónica
Published: March 2022

Atualmente é evidente que todas as pessoas necessitam de habilidades digitais otimizadas e é de extrema importância que os funcionários da administração pública de qualquer país fortaleçam suas habilidades digitais para sua educação e vida profissional. A administração tributária peruana conta com colaboradores com idade média de 47 anos e, portanto, é necessário ter treinamentos que atualizem e otimizem as habilidades digitais dos professores que apoiam o Instituto aduaneiro e tributário e os colaboradores da instituição. O objetivo geral é transformar o ambiente tradicional ensino-aprendizagem dos sujeitos técnicos, otimizando as habilidades digitais dos professores e participantes para que utilizem eficientemente as ferramentas digitais, utilizando de forma otimizada os meios tecnológicos de comunicação e colaboração, o resultado será aplicável não só ao trabalho docente, mas às suas próprias funções dentro da instituição.
CRIMES AMBIENTAIS
Authors: SOUSA VIDAL RENAN , HOCH VIEIRA FERNANDES CAROLINA , DO NASCIMENTO JAMILSON , STEMPCZYNSKI ANA PAULA
Published: March 2022

O trabalho tem como objetivo analisar a legislação ambiental relativa aos crimes ambientais no contexto nacional, buscando uma melhor compreensão sobre o conceito meio ambiente, educação ambiental assim como outros assuntos relacionados à gestão ambiental e crimes ambientais. Procurando sempre enfatizar a execução de políticas públicas e a prevenção da prática desses atos ilícitos, que, na maioria das vezes são praticados de forma silenciosa.
IMPACTO DE LAS ADAPTACIONES CURRICULARES INDIVIDUALES EN NIÑOS CON NECESIDADES EDUCATIVAS ESPECIALES, ASOCIADAS A DISCAPACIDAD INTELECTUAL DE ESCUELAS PÚBLICAS CON PROYECTOS DE INTEGRACIÓN ESCOLAR
Authors: Anriquez Ponce Gabriel , Oliva Urrutia Claudia
Published: March 2022

Esta investigación fue realizada con la finalidad de establecer el impacto de las adaptaciones curriculares individuales poco significativas y/o significativas en niños con Necesidades Educativas Especiales (NEE) de escuelas públicas de una comuna de la región de La Araucanía en Chile, que cuentan con Proyectos de Integración Escolar (PIE). Este tema es amplio por lo que este estudio se ha centrado en identificar los factores que influyen en los resultados de las Adaptaciones Curriculares Individuales (ACI), aportando un marco teórico que permita satisfacer los requerimientos bibliográficos de la investigación. La metodología es cuantitativa y la información fue recogida a través de cuestionarios tipo encuestas realizadas a docentes, padres y apoderados. Los resultados fueron presentados en gráficos porcentuales los que fueron interpretados para identificar el impacto de las ACI en niños con NEE de escuelas públicas de una comuna de la región de La Araucanía en Chile, que cuentan con Proyectos de Integración Escolar (PIE) y los factores que influyen en el éxito o fracaso de esas adaptaciones curriculares individuales. La investigación concluyó que las ACI no son eficaces, representando un bajo impacto en los niños que integran los PIE. Entre los principales factores que explican este bajo impacto se encuentran las continuas interrupciones que experimenta el docente al interior del aula y el consiguiente escaso tiempo que posee para realizar las actividades planificadas.
European Commission suspends cross-border cooperation with Russia
Authors:   Institute of Europe of Russian Academy Sciences, Kondratieva Natalia
Published: March 2022

On March 4, 2022, the European Commission imposed sanctions on cross-border cooperation with Russia as well as Belarus. The author evaluates actions of the Commission as one of the parties to relevant agreements. The author proves that the sanctions will affect not Russia, but the beneficiaries in the EU member states. The ongoing search in the EU for opportunities to reorient finances to solve pressing problems related to the influx of refugees from Ukraine will lead to rejection of the priorities of sustainable development in the neighborhood policy put forward earlier by the Commission itself.
Significance of the visits of Federal Chancellor O. Scholz to Washington, Kiev and Moscow for relations between Russia and Germany
Authors:   Institute of Europe of Russian Academy Sciences, Belov Vladislav
Published: March 2022

Federal Chancellor Olaf Scholz held talks with US President John Biden on February 7, 2022 in Washington, on February 14 in Kiev with Ukrainian President V. Zelenskyy and on February 15 in Moscow with Russian President V.V. Putin. The focus of all meetings was on the situation on Russian-Ukrainian border and energy cooperation between the EU and Germany with Russia. The paper analyzes the importance of the Chancellor's agreements for the future of Russian-German relations.
Reaction of Germany to the special military operation of Russia on the territory of Ukraine
Authors:   Institute of Europe of Russian Academy Sciences, Belov Vladislav
Published: March 2022

The government, political and economic establishment of Germany, as well as all sectors of society, reacted extremely negatively to Russia's recognition of LPR and DPR and subsequent special military operation on the territory of Ukraine. Germany has become a key player in development and adoption of EU's sanction packages against Russia. The author analyzes the most important decisions of the German cabinet of ministers, actions of interest groups and their consequences for German- Russian relations.
Rumunjsko-jugoslavenski odnosi, od sukoba do suradnje (1948. – 1964.)
Authors: Bajora Anatolie , Constantinov Bogdan-Tudor
Published: March 2022

Ovaj članak proučava razvoj rumunjsko-jugoslavenskih odnosa od 1948. do 1964. godine. Istražuju se dva različita razdoblja u njihovim odnosima. Prvo je od 1948. do 1953. godine, kad je došlo do sovjetsko-jugoslavenskog i rumunjsko-jugoslavenskog sukoba koji je, zapravo, predstavljao presedan koji će postupno razoriti jedinstvo socijalističkog tabora. Za drugo razdoblje (od 1954. do 1964.) vezani su početak normalizacije i zbližavanje Bukurešta i Beograda. To je odgovaralo njihovim nacionalnim interesima i predstavljalo je protutežu politici supersila. U vanjskoj politici dviju zemalja odražavali su se ideološka neslaganja i potreba za društveno-ekonomskim razvojem, a osjećao se i snažan utjecaj i iz komunističkog bloka i izvan njega.
Estrogen mediated differential protein regulation and signal transduction in rheumatoid arthritis
Authors: Chakraborty Debolina , Sarkar Ashish , Mann Sonia , Monu Monu , Agnihotri Prachi , Saquib Mohd , Malik Swati , Kumavat Rajkamal , Mathur Anushka , Biswas Sagarika
Published: March 2022

Exploration of the dual and opposing facets of estrogen (E2) necessitate a clear understanding to diminish the controversy of estrogen regulation in averting the systemic, autoimmune, joint degrading disorder, rheumatoid arthritis (RA). Experimental evidences consider estrogen as a pivotal enzyme to modulate the disease progression via managing several cellular mechanisms targeting inflammatory markers such as TNF, ILs, NF-κB and other regulatory proteins like MMPs impeding joint erosion and cartilage degradation. E2 modulates cellular signalling associated with inflammation, oxidative stress, related cardiovascular risk and miRNA regulation during RA progression. Studies determining E2 regulation in RA complicate the resemblance of the outcome as they represent both hyper and hypo level of E2 linked to the disease. Although some reports deliver E2 as malign, there is now increasing evidence of rendering protection dose dependently. Variation in estrogen level cause differential expression of certain proteins and their related signalling which directly or indirectly linked to RA pathogenesis. This review summarizes the variations in protein expression levels by focusing on the in vitro, in vivo and clinical studies of E2 deficiency and treatment. Construction of PPI network, GO and KEGG pathway enrichment analysis of the differentially expressed proteins assist in hypothesizing a potential molecular mechanism of E2 in RA via in silico studies. Targeting these differential proteins can emerge a new path for developing advanced therapeutic strategies.
Por unha España republicana e democrática. Renovación identitaria e disenso simbólico na Galicia da Segunda República (1931-1936)
Authors: Frieiro Santaya Javier
Published: March 2022

Neste traballo abordarase o proceso de renovación da identidade nacional española que os republicanos se propuxeron acometer dende o seu acceso ó poder en 1931. Concretaremos esta renovación na substitución do vello corpus simbólico oficial por outro capaz de representar e difundir os novos valores, así como as súas relacións cos propios dos aliados do réxime republicano e o dos seus máis reaccionarios opositores. Pese ó carácter accidentado da substitución -brevidade do réxime, necesaria conciliación cos emblemas propios dos aliados do republicanismo ou férrea oposición da dereita antirrepublicana cada vez máis reaccionaria- esta non supuxo o fracaso completo da renovación identitaria. Ao contrario, a conciencia cívica que se viñera xestando desde finais do século XIX e que posibilitara a chegada da democracia a España nos anos trinta, manteríase entón e incluso medraría, a pesar dos intentos de contela por medio dun golpe de Estado, una guerra e unha longa ditadura.
Percepciones internas y externas sobre calidad de la educación en línea
Authors: Parra-Castrillón José Eucario
Published: March 2022

Objetivo. El objetivo principal del estudio fue conocer la calidad de la educación en línea a nivel universitario. Metodología. Se utilizó un enfoque mixto con análisis convergente de datos cualitativos obtenidos de estudiantes, docentes y personas egresadas de esta modalidad educativa a través de grupos focales y entrevistas en profundidad y datos cuantitativos obtenidos de indagaciones externas a través de encuestas. Resultado. Las visiones externas no mostraron credulidad sobre la calidad de la educación en línea y, sin conocer su dinamismo curricular, exhibieron desconfianza sobre las competencias de las personas egresadas, lo que explica por qué aún con el auge del mundo virtual, la educación superior continúa siendo predominantemente presencial. Por otro lado, las visiones internas revelaron confianza en la calidad y confirmaron conceptos teóricos sobre aprendizajes en la virtualidad relacionados con mediaciones pedagógicas, plataformas tecnológicas educativas, competencias pedagógicas del personal docente, construcción de aprendizajes y participación continua del estudiantado. Conclusiones. Estos hallazgos pueden ser aplicados en la renovación de los sistemas de calidad educativa enfocados en la medición positivista de factores intrínsecos, y para avanzar de un modelo de socialización y promoción basado en la flexibilidad y fácil acceso, a otro enfocado en las potencialidades pedagógicas y ventajas formativas de la educación en línea.
Information and Communication Technologies in Education 4.0 Paradigm: a Systematic Mapping Study
Authors: de OLIVEIRA Leonam Cordeiro , GUERINO Guilherme Corredato , de OLIVEIRA Leander Cordeiro , PIMENTEL Andrey Ricardo
Published: March 2022

Industry 4.0 technologies are being applied in the teaching and learning process, called Education 4.0. However, there is no specification of what is being considered when developing technologies for education in the 4.0 context. Therefore, we performed a Systematic Mapping Study to investigate the information and communication technologies (ICTs) proposed to Education 4.0. From a search in four search engines, 81 articles had data extracted. The results elucidated aspects considered as Education 4.0, such as contextualized learning and student-centered learning. Besides, some applied ICTs are not in agreement with the ICTs considered as 4.0 in the literature, the focus on ICTs to engineering education and to be applied to higher education. As implications of the results obtained, it is necessary to understand why some ICTs are not aligned with 4.0 literature and apply these ICTs in knowledge areas beyond STEM.
Specifics of Happiness Felt Over by Students with Different Life-Purpose Orientations
Authors: Garanina Zhanna G. , Andronova Natalia V.
Published: March 2022

Introduction. The integral concept of happiness relies on understanding the influence on its feeling specifics, the external conditions of life. Moreover, it depends on the individual psychological properties and states of the personality and its semantic and value orientations. Despite a great deal of works devoted to this phenomenon, there are practically no publications in the scientific literature on the relationship between the degree of happiness experienced by students and their meaning-of-life orientations, which determined the purpose of our study – to study the features of the relationship between meaning-of-life orientations and the level of happiness of students. Materials and Methods. The results of an empirical study among students of the Mordovia State University in various fields of training are presented. The sample size is 110 people. The study was conducted using several test methods: “Oxford Happiness Questionnaire” by M. Argyll, “Existence Scale” by A. Langle and K. Orgler (translated by S. V. Krivtsova), “Life-Sense Orientations (LSS)” by J. Crumbaugh and L. Makholik (adapted by D. A. Leontiev). Spearman’s rs rank correlation test, factor, cluster analysis and Mann-Whitney U test were used for mathematical processing. Results. In the course of the study, the features of life orientations, existential values of students and their level of happiness were studied. The results show that the level of happiness, meaningfulness and fulfillment of life among students does not depend on the profile of their education (natural science or humanities). Statistically significant correlations between the level of happiness and the degree of fulfillment of life, self-transcendence, freedom, personality, existentialism, self-distancing, as well as the meaningfulness of students' life, were revealed. As a result of factor analysis, three groups of factors were identified that link the indicators of meaningfulness, existentialism and fulfillment of life with the level of happiness of the subjects: “Meaningfulness of Life”, “Productivity of Life” and “Level of Happiness”. Discussion and Conclusion. The conclusions made by the authors contribute to the development of ideas about the dominant life orientations of students and their influence on the experience of happiness. The materials of the article can be used in teaching and psychological counseling of students to increase the degree of awareness of the meanings, goals and process of life, which can contribute to an increase in their level of happiness.
Influence of the Population Religious Diversity on the Socio-Economic Indicators of the Russian Federation Regions
Authors: Gravchikova Alina A.
Published: March 2022

Introduction. In the modern world globalization leads to the active interaction of representatives of different cultures. However, there are questions of how this affects the life of society. The purpose of this article is to assess the religious diversity impact on the well-being level of the population of the Russian Federation regions.

Materials and Methods. For analysis the author has used data from the Atlas of Religions and Nationalities of Russia “Arena” and the Federal Agency for Ethnic Affairs. Religious diversity was assessed using two indicators: the Simpson Diversity Index and the Polarization Index. The paper considers the consumption level as an indicator of well-being. On the one hand, the consumption level reflects independently the standard of living; on the other hand, it is an element of gross output. The correlation between religious heterogeneity and the well-being indicator was checked by using regression analysis. Besides the panel regressions were also evaluated.

Results. The economic analysis confirms that religious diversity is directly proportional to the divorce rate, which has a negative impact on the consumption level in the Russian Federation regions. In addition, there are direct negative relationship between confessional heterogeneity and consumption. The results lead to the conclusion that religious diversity negatively affects economic indicators through the social sphere.

Discussion and Conclusion. The general conclusion is that during the period under consideration, there is trend of the gradual reduce of the religious diversity. These processes are a favorable basis for increasing the well-being indicators of society because they reduce the negative impact of religious heterogeneity on the whole as well as on the consumption level. The data, the methods and the obtained results can be used as a basis for further research. The estimates and the conclusions could be taken into account in the socio-economic policy.