P-2356. A SFGM-TC real-world study to characterize pediatric patients undergoing allogeneic Hematopoietic Stem Cell Transplantation (HSCT) and identify the cytomegalovirus (CMV) serology status of both recipients and their donors
Authors: Bourge Xavier , Tournaire Guilhem , Dalle Jean-Hugues , Neven Bénédicte , Ouachée-Chardin Marie , Sterin Arthur , Jubert Charlotte , Bruno Bénédicte , Gandemer Virginie , Pochon Cécile , Rialland Fanny , Paillard Catherine , Robin Marie , Sirvent Anne , Buchbinder Nimrod , Plantaz Dominique , Kanold Justyna , Guillerm Gaelle , Daguindau Etienne , Huynh Anne , Charbonnier Amandine , Suarez Felipe , Maillard Natacha , François Sylvie , Malfuson Jean-Valère , Devillier Raynier , Raus Nicole , Nguyen Stephanie 
Published: January 2025

Background

The aim of this study was to perform a description of pediatric patients’ characteristics undergoing an allogeneic Hematopoietic Stem Cell Transplantation (HSCT) and to identify their cytomegalovirus (CMV) serology status and that of their donors

Methods

Patients under the age of 18 who received an allogeneic HSCT in a French center reporting data in the ProMISe database of the francophone society of bone marrow transplant and cellular therapy (SFGM-TC) during the period comprised between January 1, 2019, and December 31, 2021

Results

904 allo-HSCT were performed between January 1, 2019, and December 31, 2021, in 22 hematopoietic stem cell transplant centres in France. Among them 57,5% (520) were males (Figure 1). Patients ages were analysed with 14,7% (133) being strictly below 2 years old, 29,8% (269) being between 2 and 6 years old, 25,9% (234) being between 7 and 11 years old and 29,7% (268) being between 12 and 18 years old. Age classes distribution wasn’t different throughout the years analysed, as shown in Figure 2

CMV serostatus of both donor and recipient were available for 96% of patients. Donor negative and Recipient negative (D-/R-) accounted for 32% of the population, Donor positive and Recipient negative (D+/R-) accounted for 16%, Donor Positive and Recipient positive (D+/R+) accounted for 29% and lastly Donor negative and Recipient positive (D-/R+) accounted for 19%. Serostatus was analysed through age classes (Table 1) showing a numerical trend toward a higher CMV seropositivity for recipient being older than 2 years old. R+ patients were 42,1% below 2 years old and 49,3% in the 2 to 6-year-old age group. The percentage remained stable in older patients.

The primary diagnoses leading to the graft were mainly primary immune deficiency for patients under 2 years old, accounting for 45.1% (60/133). After 2 years old, the leading cause was acute leukaemia (Table 2). Pediatric patients mainly received bone marrow (71%) as the source of stem cells, followed by cord blood (18%) and peripheral blood (11%).Table 1CMV Serostatus according to age of recipients

Conclusion

The diagnosis leading to HSCT in the pediatric population differs according to age class. Serostatus also differs according to age class, with older patients approaching the levels of seropositivity seen in adults.

Disclosures

Xavier Bourge, PharmD, MSD France: Employee Guilhem Tournaire, MD, MSD France: Employee Jean-Hugues Dalle, MD, MSD France: Advisor/Consultant Bénédicte Neven, MD, MSD France: Advisor/Consultant Marie Robin, MD, MSD France: Grant/Research Support Raynier DEVILLIER, MD, MSD France: Grant/Research Support Nicole Raus, n/a, MSD France: Grant/Research Support Stephanie Nguyen, n/a, MSD France: Grant/Research Support