bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPLEMENTATION OF FUZZY LOGIC CONTROLLERS TO MAINTAIN WATER TEMPERATURE IN HYDROPONICS NFT FOR LOLLO VERDE LETTUCE (LACTUCA SATIVA L.)
Authors: FAUZAN MOHAMAD NURKAMAL , SAPTARINI NYI MEKAR
Published: March 2021

Objective: The purpose of this study was to maintain the nutritional water temperature in the range of 25-27 °C for Lollo Verde lettuce (Lactuca sativa L.).

Methods: The method was the Fuzzy Logic Mamdani (FLM) with two inputs, i.e. real time clock and temperature. The output was crisp speed PWM with the center of area method.

Results: The results showed that Fuzzy logic was succeeded in reducing water temperature in the NFT system from 28-32 °C to 26-27 °C, with an average delta of 3.5 °C. Fuzzy logic maintained the nutrient water temperature in the Lollo Verde lettuce with an average of 26.57±0.5 °C. Water temperature affected the yield of Lollo Verde lettuce.

Conclusion: The yield of NFT FLM system was better compared to the conventional NFT system.
PREPARATION AND CHARACTERIZATION OF ENTERIC-COATED DELAYED-RELEASE MICROSPHERE OF PHYTOSOME LOADING ALLICIN-RICH EXTRACT
Authors: NINING NINING , SRIFIANA YUDI , FADLIANTY ELY MALINDA
Published: March 2021

Objective: Allicin, a natural organosulfur compound, is the main garlic ingredient, which has extensive pharmacological activities. Its unstable under acidic conditions due to alliinase's inactivation causes the need for preparations that delayed-release in the stomach to maximize allicin absorption. This study aimed to prepare and characterize the enteric-coated microsphere of phytosome loading allicin-rich extract to protect it from gastric acid.

Methods: The allicin-rich extract phytosome (ArE-Ps) was prepared and evaluated for characteristics. Microsphere was made in three formulas with different molar ratios of ArE-Ps and Eudragit L30D-55 (1:1; 1:1.5 and 1:2) by spray dry. The three microspheres compared to particle size, entrapment efficiency, and dissolution test in acid and 7.4 pH medium.

Results: Optimized ArE-Ps has a size of 251.6 nm, polydispersity index 0.466, zeta potential 34.11, entrapment efficiency of 62.62 %, and specific gravity of 1,005 g/ml. The surface topography of the three formulas shows an almost spherical shape with concave surfaces. The particle size of the microsphere ranges from 215±6.27 nm to 548.8±10.15 nm. Entrapment efficiency increases with an increasing number of polymers with a maximum value of 65.44 % at F3. The results dissolution test in vitro showed no drug release in acidic medium, and drug release occurred at a 7.4 pH medium. Drug release of three microsphere formulations followed the Korsmeyer-Peppas model with a k value of 12.7088±0.1769; 17.9322±1.5621; and 12.958±1.2677; respectively.

Conclusion: Based on these results, the polymer's increase in three microsphere formulations can affect characteristics and retain drug release under acidic conditions.
UFASOMES: UNSATURATED FATTY ACID BASED VESICULAR DRUG DELIVERY SYSTEM
Authors: ARUNDHASREE  , R. RAJALAKSHMI , R. AISWARYA , KUMAR ABHIRAMI RAJENDRA , KUMAR SREELAKSHMI S. , NAIR SREEJA C.
Published: March 2021

Various novel drug delivery systems have been developed encompassing several administration routes to deliver drugs at a rate decided as per the need of the body during the course of treatment and to achieve targeted therapy, also decreases undesirable side effects. Different types of vesicular drug delivery systems were developed, such as liposomes, niosomes, ufasomes etc. Ufasomes are unsaturated fatty acid vesicles which is a suspension of closed lipid bilayer formed from fatty acid and their ionized species having limited, narrow pH ranging from 7-9. Composition of fatty acid molecules is such that the hydrocarbon tails are pointed towards the inner core of the membrane and the carboxyl group are in touch with water. Stable ufasomes preparation mainly relies on appropriate choice of fatty acid, cholesterol quantity, range of the pH, buffer and lipoxygenase amount. Recent innovation provides very efficient features such as stability considerations, dynamic features and microscopic features of ufasomes. The article furthermore provides the difference between ufasomes with liposomes. For this review, the complete databases have been collected from various search engines such as researchgate, elsevier, pubmed, sciencedirect, google scholar, scopus etc., from the year 1965-2020 using the following keywords.
COMPARATIVE STUDY OF SEVEN BRANDS OF LEVOFLOXACIN 500 MG FILM-COATED TABLET MARKETED IN YEMEN
Authors: OTHMAN GAMIL Q. , AL-WORAFI YASER M. , BATTAH MOHAMMED M. , HALBOUP ABDULSALAM M. , HASSAN HASSAN M.
Published: March 2021

Objective: The objective of the current study was to evaluate the quality control parameters of seven brands of levofloxacin 500 mg film-coated tablet available in the Yemeni market.

Methods: Physicochemical parameters assay was performed for seven brands of levofloxacin 500 mg film-coated tablet. Each brand was subjected to official and unofficial in vitro quality control tests, including weight variation, thickness, hardness, friability, disintegration, dissolution, and content uniformity assay by High-Performance Liquid Chromatography (HPLC).

Results: Out of seven, six brands of levofloxacin 500 mg film-coated tablet passed official specified assay tests according to the United States Pharmacopeia (USP) specifications. They showed a similar profile of thickness ranged between±0.01 and 0.10%, friability ranged between 0.01% and 0.34%, disintegration time ranged between 3.00 and 15.00 min, dissolution percentage ranged between 90.650 and 103.05 and content uniformity ranged between 93.62 and 107.12%. Regarding weight variation and hardness, six brands passed the weight variation test and only three brands showed optimum range (10-20 kg) of hardness test. Only one brand failed to pass the weight variation test, and four brands failed to pass the optimum range (10-20 kg) of hardness.

Conclusion: There are no remarkable differences between the seven brands regarding in vitro quality control tests of content uniformity, thickness, friability, disintegration, and dissolution. Even though four brands were above the optimum range of hardiness, they showed complete disintegration and dissolution within the acceptable limit. Regular assessment of marketed drugs is required to ensure bioequivalent to their innovators.
IMPROVEMENT AND ESTIMATION OF ORALLY DISINTEGRATING TABLETS CONTAINING PILOCARPINE 2-HYDROXY PROPYL β-CYCLODEXTRIN INCLUSION COMPLEX BY RESPONSE SURFACE METHODOLOGY
Authors: TRIPATHY JOGABRATA , SAHOO SUBHASHREE , MOIN AFRASIM , SIDDARAMAIAH  , GOWDA D. V.
Published: March 2021

Objective: The study aimed to develop and evaluate an orally disintegrating tablet that contains pilocarpine and 2-hydroxy propyl β-cyclodextrin as an inclusion complex that is prepared by lyophilization used for treatment for dry mouth. Pilocarpine is utilized to treat dry mouth disorder. The inclusion complex lowers the taste of pilocarpine through the oral mucosa by the use of 2-hydroxy propyl β-cyclodextrin.

Methods: The in vitro release from the insertion complex is also been studied. The parameters like differential scanning calorimetry (DSC), Fourier transformer infrared spectroscopy (FTIR), X-ray diffraction (XRD), and morphological study have been evaluated. The design of an experiment is carried out based on the concentration of croscarmellose sodium (CCS) and microcrystalline cellulose (MCC). Evaluation of the prepared orally disintegrating tablets have been carried out by different test methods like weight variation, thickness, drug content, disintegration, and in vitro dissolution study.

Results: Orally disintegrating tablets are studied by utilizing the immediate pressure technique. Pilocarpine indicates the anhydrous crystalline medication, displaying sharp endothermic top at 120.2 °C, bend of 2-HPβCD demonstrates an exceptionally wide endothermal wonder among 55-100 °C for DSC. In pilocarpine spectra, characteristic band of aromatic C-H stretch at 3277 cm-1, C=C stretching at 1608 cm-1, C-N stretching at 1445 cm-1 and methoxy (CH3-O-) stretch at 2921 cm-1 was observed. The investigation shows that tablet hardness of 4.3N, breaking downtime of 12 sec and mean disintegration time is 1.562 min.

Conclusion: The different diluents and super disintegrating have been applied for the quick elevation of dry mouth that helps us for patient compliance.
DESIGNING AND OPTIMIZATION OF NAPROXEN SODIUM DEFORMABLE VESICULAR SYSTEMS THROUGH FACTORIAL DESIGN: BOX BEHENKEN MODEL
Authors: GUPTA NAVEEN , JAIN SHAILESH
Published: March 2021

Objective: The objective of this investigation was to develop and statistically optimize deformable vesicles such as transfersomes and transethosomes of Naproxen sodium by employing 33factorial designs through software Design expert version 12 (Box–Behnken design) for dermal delivery.

Methods: The levels of the drug, phosphatidylcholine, and span 80 (independent variables) were varied to study the influence on vesicle size and % entrapment efficiency (dependent variables) of transfersomes and for transethosomes, the levels of phosphatidylcholine, ethanol, and span 80 were selected as independent variables Second-order quadratic polynomial equation, 2D and 3D contour plots represented the relationship between variables and desired response. The optimization process was carried out using desirability plots and point prediction techniques.

Results: Results of the present study demonstrated that optimized transfersomes and transethosomes showed vesicle sizes of 114.91 nm and 102.91 nm respectively, while entrapment efficiency of 80.11 % and 86.97%, respectively. Both formulations showed high zeta potential values indicating the stability of the optimized formulation. ANOVA statistical results showed a significant difference (P<0.05).

Conclusion: The results indicated that the independent variable plays a crucial role in optimizing a formulation that can be used for further research studies. Present preliminary study data provided strong evidence that the optimized deformable vesicular formulations through box Behnken factorial design can be a potentially useful drug carrier for naproxen sodium dermal delivery with minimum vesicle size and efficient entrapment efficiency.
NOSE-TO-BRAIN DRUG DELIVERY: AN UPDATE TO THE ALTERNATIVE PATH TO SUCCESSFUL TARGETED ANTI-MIGRAINE DRUGS
Authors: CHATTOPADHYAY SOUVIK , DAS SUJIT , SARMA KOUSHIK NARAYAN
Published: March 2021

The Blood-Brain Barrier (BBB) limits transportation to the brain of possible treatment moieties. Specific stimulation of the brain through olfactory and trigeminal neural pathways by BBB has been taken into consideration for the development of a wide spectrum of brain therapeutics. The intranasal delivery path delivers the drugs through the brain, eliminating any side effects and increasing neurotherapeutics performance. Diverse drug delivery systems (DDDss) for reaching the brain via the nasal route have been researched over the past few decades. Large-scale molecular biologics, such as Deoxyribonucleic acid (DNA), gene vectors, and stem cells, can be administered intranasally, as a method for the management of a range of CNS illnesses, including stroke, Parkinson's diseases, multiple sclerosis, Migraine, Alzheimer's diseases, epilepsy, and mental disorders. New DDSs, including nanoparticles, liposomes, and polymeric micelles, have acquired potentials in the nasal mucosa and central nervous system (CNS), as effective means of concentrating the brain without toxicity. Differential nasal cavity structures posed a significant obstacle in ineffective drugs beyond the nasal valve. Pharmaceutical firms have increasingly used emerging techniques for the production of new nasal pharmaceutical drugs to overcome these obstacles. This review aims to identify the new advances in the nasal administration of brain-based DDSs for Migraines.
MASTIC-G-POLY (ACRYLAMIDE): MICROWAVE-ASSISTED SYNTHESIS AND CHARACTERISATION
Authors: KUMAR MOHIT , SURAJPAL
Published: March 2021

Objective: The objective of the present investigation was the synthesis of grafted co-polymer gum mastic using acrylamide as the monomer.

Methods: 3-factor 3-level response surface Box-Behnken design, which requires 15 runs including three replicates of the central run, was used for the synthesis of graft copolymers of mastic gum with acrylamide using ceric ammonium nitrate as the free radical initiator. The critical synthesis and process parameters; CSPP (A = concentration of monomer, B = concentration of initiator and C= Temperature) to generate design space and optimize formulation with an aim to obtain critical quality attributes (CQA, Y1 =% Yield, Y2 =% Grafting, Y3 =% grafting efficiency).

Result: Formulation F14 having a maximum % yield of 75.89% with % grafting of 210% and % grafting efficiency 51.57% was selected as best.

Conclusion: The microwave-assisted grafted mastic gum was prepared successfully and optimized by using Box Behnken design.
IN SILICO STUDIES ON DIACYL DERIVATIVES OF PHLOROGLUCINOL TO ENHANCE PHARMACODYNAMIC AND PHARMACOKINETIC PROFILES OF 2,4,6-TRIHYDROXY-3-GERANYL-ACETOPHENONE
Authors: CHIONG SHEAU WEI , NG CHEAN HUI , SHAARI KHOZIRAH
Published: March 2021

Objective: The purpose of this study was to evaluate the LOX inhibitory activity, and predict the drug likeness properties of designed diacyl derivatives of phloroglucinol, using in silico method.

Methods: The designed derivatives were subjected to molecular docking using AUTODOCK while the receptor used in this study was built from SWISS MODEL. Drug likeness properties of the derivatives were calculated by online programs i.e. MOLINSPIRATION and PreADMET.

Results: Molecular docking study revealed that designed tHGA derivative with four-carbon chain length exhibited the best binding affinity with the docking scores of -7.26kcal/mol. Three types of binding interactions were observed between the derivatives and the receptor site i.e H-bonding, hydrophobic and Van der Waals interactions. The important amino acid residues involved in H-bonding were Gln495 and Gln697, while other amino acid residues, such as Leu754 and Ile 553, were involved in the Van der Waals interaction. The designed tHGA derivatives were mainly stabilized through hydrophobic interactions with His499, His504, Ile538, Phe557 and Val750. In silico physicochemical calculations predicted that all the designed derivatives passed the Lipinski’s Rule of 5, and have good human intestinal absorption property (HIA>70%). Further, all the designed derivatives showed moderate central nervous system absorption (0.6<BBB<2.0), except for the derivative with a longer (5-Cs) chain length.

Conclusion: The findings of the present study suggested that changing the acyl and geranyl side chains of the natural product molecule, tHGA, into two acyl bearing side chains, will improve its pharmacodynamic and pharmacokinetic profiles.
In Sickness and in Health
Authors: Waterson Amy
Published: March 2021

A brief introduction to FORUM's 31st issue, "Art, Disease, and Expression".
Exploring the Virulent Jazz Counterculture in Mumbo Jumbo
Authors: Mishra Debangana
Published: March 2021

This article will be focusing on Ishmael Reed’s Mumbo Jumbo (1972), a vibrant postmodernist text, which offers a fresh perspective on the rise of black popular culture in the form of Jes Grew, which is largely informed by jazz and neo-hoodoo aesthetics. Jes Grew, the phenomenon which binds the multifaceted text in cohesion and brings together elements from History, Jazz and Afrofuturism, is communicated by using the metaphor of a virulent disease- the Jes Grew pandemic. The article is a work in cultural studies, attempting to map the evolution of the counter culture that Jes Grew represents and its effect on identity. This mapping is achieved by viewing the equation of the Jazz counter-culture with the Jes Grew pandemic. Jes Grew decodes the cultural and racial politics Mumbo Jumbo is invested in by destabilising the meaning and perspective attached to ‘disease’ and adapting it to an entirely new climate of cultural reclamation and celebration by deconstructing the dominant culture defined illness (Jes Grew in the text) and reinterpreting it as potentially healing and liberating. The discussion of the politics and aesthetics of this counter-culture mainly hinges on the central metaphor of the Jes Grew pandemic operating throughout the narrative. Raymond Williams’ work on culture studies and Stuart Hall’s theory on the formation and representation of cultural identities are particularly helpful in discussing the issues of culture and identity that are in dialogue with the narrative.
МИКРОСТРУКТУРА 3D-ОБЪЕКТОВ. ТЕХНОЛОГИИ КОМПАНИИ MICROLIGHT3D ДЛЯ СОЗДАНИЯ ОБЪЕКТОВ МИКРО- И НАНОМИРОВ
Authors: Барбье Д. , Кордейро Ж.
Published: March 2021

Разработка технологии процесса трехмерной печати, основанной на двухфотонной полимеризации, продолжалась в течение 15 лет и завершилась основанием компании Microlight3D. Создателям удалось воплотить в жизнь уникальную технологию печати микро- и нанообъектов при помощи свободно перемещающегося по трем координатам лазера, обеспечивающего непрерывную печать в среде из полимерного резиста. Сейчас технологии компании обеспечивают невероятно высокое разрешение печати и непревзойденное качество поверхности создаваемых микро- и нанообъектов. О новых технологиях, инновациях, оборудовании и продуктах компании Microlight3D рассказывают президент компании Денис Барбье и менеджер по продажам Жюльен Кордейро. The development of the 3D printing process technology based on two-photon polymerization has continued for 15 years and culminated in the founding of Microlight3D. The founders managed to bring to life the unique technology for micro- and nano-objects printing using a laser that moves freely in three coordinates, which ensures continuous printing in a polymer resist medium. Nowadays the company’s technologies now provide incredibly high print resolution and unsurpassed surface quality for micro- and nano-objects being created. Microlight3D President Denis Barbier and Sales Manager Julien Cordeiro talk about new technologies, innovations, equipment and products of Microlight3D.
Год науки и технологий
Authors: Яминский И.В.
Published: March 2021

2021 год объявлен в России годом науки и технологий. В Советском Союзе наука
основывалась на государственном задании (приоритетах) и стараниях ученых.
В современной России наука существует благодаря государственной поддержке,
увлеченности ученых и коммерции. Коммерция в России иногда невероятно успешно
выстреливает, как это произошло во многих направлениях ИТ-индустрии, но часто
и хромает – радио и электроника, компьютеры и телефоны, автомобили и пр. В настоящей статье мы ищем пути научного прорыва, устранения препятствий на пути ускоренного развития российской науки и технологий, в том числе в области нанотехнологий.
This year, 2021, has been declared the year of Science and Technology in Russia. The science in the Soviet Union was based on state assignments (priorities) and the efforts of scientists. In modern Russia science exists thanks to government support, enthusiasm of scientists and commerce. Commerce in Russia sometimes shoots incredibly well, as has happened in many areas of the IT industry, but often it is also lame – radio and electronics, computers and phones, cars, etc. In this article, we are looking for ways of a scientific breakthrough, removal of obstacles and accelerated development of Russian science and technology, including nanotechnology.
Registro de zorrillo pigmeo (Spilogale pygmaea) en Compostela, Nayarit, México
Authors: Alba Preciado María Azucena , Dueñas Romero José Jesús
Published: March 2021

RESUMENEn septiembre de 2020 fue registrado el atropellamiento de un ejemplar de zorrillo pigmeo (Spilogale pygmaea) a 1.39 kilómetros al norte de Zacualpan, municipio de Compostela, Nayarit, México. Este es el segundo registro de zorrillo pigmeo en el municipio de Compostela después de 50 años de su primer registro y el tercero en el estado de Nayarit. Este trabajo pone de manifiesto la importancia de los estudios sobre atropellamientos de fauna silvestre en las carreteras del estado de Nayarit.Palabras clave: atropellamiento, carreteras, Compostela, endémica, especie amenazada, Nayarit, Spilogale pygmaea.ABSTRACTIn September 2020, a pygmy skunk (Spilogale pygmaea) was run over 1.39 kilometers north of Zacualpan, Compostela municipality, Nayarit, México. This represents the second skunk record in the municipality of Compostela after 50 years and the third for the state of Nayarit. This work highlights the importance of studies on the run over of wildlife on the roads of the state of Nayarit.Key words: Compostela, endemic, Nayarit, roads, run over, Spilogale pygmaea, threatened species.
Interaction between a long pile and multi-layer underlying soils
Authors: Ter-Martirosyan Zaven G. , Akuletskii Aleksandr S.
Published: March 2021

Introduction. The majority of construction sites feature complex geotechnical conditions, as they have alternating soil layers, including loose soils. A pile foundation is the principal type of foundations constructed on these sites. This article encompasses a problem statement and a solution to the problem of interaction between a long pile and multilayer underlying soils.

Materials and methods. The problem is explored in linear and nonlinear settings. The S.P. Timoshenko elastoplastic model is analyzed to describe nonlinear shear deformations. Analytical and numerical methods are employed to present the solution. The results of the analytical solution are compared with the results of the elastic problem obtained using the Plaxis 3D software package.

Results. An equation designated for determining the reduced shear modulus of the multilayer soil mass is obtained. Analytical solutions are supported by the graphical solution obtained using Mathcad software. Numerical solutions are obtained using the Plaxis 3D software package. The diagrams describing the dependence of the settlement of the pile, that passes through alternating soil layers, on the load are provided. The diagrams, describing the dependence between the force, applied to the pile toe, and the pile radius in case of a variable load applied to the pile head and variable pile length are provided.

Conclusions. The resulting dependence, needed to determine the reduced shear modulus of the multi-layer soil mass, demonstrates good convergence with numerical methods in the elastic setting. These solutions can be used to pre-determine the displacement of a long pile surrounded with the underlying multi-layer soil mass. The selection of an optimal correlation between the pile length and the pile diameter allows for the most effective use of the bearing capacity of the pile.
Performance comparison of various types of embankment dams in relation to the conditions of the Mullalakh HPP
Authors: Podvysotckii Aleksei A. , Sainov Mikhail P. , Kirichenko Andrey Yu.
Published: March 2021

Introduction. Several types of embankment dams are used in the hydraulic engineering practice. However, the choice of a dam is individual for each hydraulic engineering project, as it takes account of specific features and natural conditions. This paper compares two types of rockfill dams (the one having a concrete face and the other having an asphalt-concrete diaphragm) in relation to the Mullalakh HPP on the Pskem River in the Republic of Uzbekistan. The dam height is 85 m. The comparison was performed from the standpoint of the dam performance in case of exposure to static forces and high seismicity.

Materials and methods. The analysis of (1) the stress-strain state (SSS), (2) the stability of slopes exposed to regular and irregular load combinations was conducted for two types of dams. All calculations were performed in the two-dimensional domain. The analysis of the stress-strain state took account of the non-linear behavior of the soil ground and the contact interaction between structural elements. Seismic loads, included into the scope of irregular loads, were identified using the response spectrum method applied to particular periods and self-oscillation modes. Slope stability was analyzed with regard for the stress state of soils identified in the course of SSS calculations.

Results. Each type of embankment dams has its specific features. The asphalt diaphragm dam is worse at perceiving high seismic loads. Its SSS during an earthquake features strength loss and emergence of soil discontinuity zones. The disadvantage of a concrete face dam is the insufficient safety of its anti-seepage element. Supplementary measures are needed to ensure the appropriate stress state of the face. Another finding is that the slopes of both types of dam do not demonstrate a sufficient stability factor, if the slope ratio equals to 1.5 during a 9-point earthquake.

Conclusions. In high seismicity regions, a concrete faced dam demonstrates better performance than the asphalt diaphragm dam if both are exposed to static and seismic forces.
O ARTIGO 22, §3º, DA LEI DE INTRODUÇÃO ÀS NORMAS DO DIREITO BRASILEIRO FRENTE AO PRINCÍPIO DO NE BIS IN IDEM
Authors: Penna Saulo Versiani , Almeida Fabíola Fonseca Fragas de , Salles Guilherme Mattos
Published: March 2021

O presente artigo tem como objetivo analisar a constitucionalidade do artigo 22, §3º, da Lei de Introdução às Normas do Direito Brasileiro. O dispositivo foi introduzido com o advento da Lei n° 13.655, de 25 de abril de 2018, e aparenta possibilitar, no âmbito do Direito Administrativo Sancionador, dupla punição, ou até mesmo múltiplas punições, de mesma natureza e em decorrência do mesmo fato. Diante desse cenário, considerando que a LINDB possui natureza de norma de sobredireito, irradiando suas diretrizes a todo o ordenamento jurídico brasileiro, torna-se importante examinar a adequação do dispositivo em estudo ao princípio constitucional implícito do ne bis in idem. Assim, a partir de uma pesquisa qualitativa, com viés analítico-dogmático, pretende-se investigar a hipótese de a prescrição em questão não observar o referido princípio e, consequentemente, a Constituição da República pátria. Ao final, uma vez conferida interpretação correta à regra, de acordo com o espírito da alteração legislativa que o estabeleceu, conclui-se pela não confirmação da hipótese levantada.
The geometry of passivity for quantum systems and a novel elementary derivation of the Gibbs state
Authors: Koukoulekidis Nikolaos , Alexander Rhea , Hebdige Thomas , Jennings David
Published: March 2021

Passivity is a fundamental concept that constitutes a necessary condition for any quantum system to attain thermodynamic equilibrium, and for a notion of temperature to emerge. While extensive work has been done that exploits this, the transition from passivity at a single-shot level to the completely passive Gibbs state is technically clear but lacks a good over-arching intuition. Here, we reformulate passivity for quantum systems in purely geometric terms. This description makes the emergence of the Gibbs state from passive states entirely transparent. Beyond clarifying existing results, it also provides novel analysis for non-equilibrium quantum systems. We show that, to every passive state, one can associate a simple convex shape in a 2-dimensional plane, and that the area of this shape measures the degree to which the system deviates from the manifold of equilibrium states. This provides a novel geometric measure of athermality with relations to both ergotropy and β--athermality.
Quantum Circuits for Sparse Isometries
Authors: Malvetti Emanuel , Iten Raban , Colbeck Roger
Published: March 2021

We consider the task of breaking down a quantum computation given as an isometry into C-NOTs and single-qubit gates, while keeping the number of C-NOT gates small. Although several decompositions are known for general isometries, here we focus on a method based on Householder reflections that adapts well in the case of sparse isometries. We show how to use this method to decompose an arbitrary isometry before illustrating that the method can lead to significant improvements in the case of sparse isometries. We also discuss the classical complexity of this method and illustrate its effectiveness in the case of sparse state preparation by applying it to randomly chosen sparse states.
Relato de experiência do uso da plataforma Google Classroom no curso de jornalismo
Authors: Cardoso Isis Nalba Albuquerque , Costa Cleide Jane De Sá Araújo , Pimentel Fernando Silvio Cavalcante
Published: March 2021

O artigo descreve a experiência de utilização da plataforma Google Classroom como Ambiente Virtual de Aprendizagem (AVA) junto aos estudantes da disciplina de oficina de produção audiovisual, ofertada nas turmas 2018.2 e 2019.1, no turno noturno do curso de graduação em Jornalismo da Universidade Federal de Alagoas (Ufal). Os objetivos foram aprofundar os conhecimentos acerca do cinema e audiovisual, complementar as aulas presenciais, além de otimizar o tempo e o interesse dos alunos nas aulas. Foram trabalhados conteúdos voltados ao audiovisual, com foco para o cinema e, em especial, as produções alagoanas. Todas as postagens e interações no ambiente virtual foram avaliadas. A culminância da disciplina se deu com a produção de curtas metragens sobre temáticas diversas.
Há insetos por todos os lados: um relato de experiência na Educação Infantil
Authors: Batalha Esthephania Oliveira Maia , Araujo Lucineide Cruz
Published: March 2021

Tendo as crianças como protagonistas dos processos de ensino e aprendizagem, este artigo apresenta uma reflexão acerca do trabalho com o tema de pesquisa “Insetos”, em uma turma da Educação Infantil do Núcleo de Educação da Infância - NEI – CAp/UFRN, Colégio de Aplicação vinculado à Universidade Federal do Rio Grande do Norte. O tema de pesquisa é a metodologia de trabalho utilizada desde a sua reestruração curricular na década de 1980, busca articular os conhecimentos dos diversos campos de experiências, o contexto sociocultural das crianças, seus interesses e suas curiosidades para compreender o objeto de estudo. No relato descrevemos algumas situações que possibilitaram o desenvolvimento de uma ação significativa com as crianças, favorecendo vivências baseadas na dialética do conhecimento. Por fim, evidenciamos os avanços significativos na ampliação dos saberes, das expressões e das linguagens das crianças.
A construção de um projeto de educação antirracista na educação infantil em uma EMEF: relatos de experiências e primeiros movimentos
Authors: Padilha Alexandra Da Silva , Zilberstein Jacqueline
Published: March 2021

Este trabalho apresenta o relato do processo de construção de um projeto de educação antirracista na educação infantil e explicita a necessidade do mesmo, através de relatos de experiência de situações racistas vivenciadas no espaço escolar. O projeto tem por objetivo implementar, de maneira efetiva e contínua, a educação antirracista a partir da educação infantil em uma Escola Municipal de Ensino Fundamental (EMEF) da Rede Municipal de Ensino da cidade de Porto Alegre (RMEPOA) no bairro Restinga e se ampara na lei 11.645/08. Iniciamos com algumas práticas a partir da metade do ano de 2020, tais como a contação de histórias com protagonistas negros, a divulgação de um painel elaborado pelo grupo intitulado Tornando-se antirracista, entre outros, pelas quais buscamos iniciar o despertar das crianças e das famílias para a temática do racismo. Procuramos assim nos desconstruir e reconstruir como professoras e pessoas antirracistas para informar e transformar através da educação.
Projetos de leitura e escrita literária para uma educação antirracista: estudando história em quadrinhos e cordel com o sexto ano do Ensino Fundamental
Authors: Becker Caroline Valada , Oliveira Samuel Gomes de
Published: March 2021

Este artigo apresenta alguns dos paradigmas teóricos (SILVA, 2007, 2015; GOMES, 2012; entre outros) e descreve algumas das práticas pedagógicas que compuseram um projeto de leitura e de escrita literária desenvolvido com turmas de sexto ano. Enquanto docentes de Literatura e de Língua Portuguesa, assumimos compromisso com a educação literária e linguística e, por isso, tornamos o texto, o ler e os e as estudantes o centro de nossas práticas. Objetivando explicitar tal perspectiva, apresentamos, aqui, fragmentos do projeto “Minha Cor, Tua Cor, Todas as Cores”, o qual se compromete especialmente com a educação para as relações etnicorraciais, mas também com a formação de leitores e de leitoras de literatura, de arte, de quadrinhos e do mundo. Um projeto de leitura com esse perfil transita entre os saberes, convocando diversas áreas do conhecimento: do currículo à sociologia; das artes à teoria da literatura; da sociologia à educação.
Um ensaio sobre o doping no esporte e a Educação Física escolar
Authors: Vasques Daniel Giordani , Stigger Marco Paulo
Published: March 2021

A Educação Física escolar é o lugar de reflexão e reconstrução das manifestações da cultura corporal. O esporte é um dos principais conteúdos da escola, nesse sentido, o doping no esporte pode ser um dos temas para pensar o alto rendimento. Duas questões fundamentais para a Educação Física perpassam essa discussão: a ética no esporte e a saúde. Assim, o objetivo deste estudo foi descrever atores, controvérsias e problemáticas do campo do doping-antidoping que podem auxiliar na tematização do esporte na Educação Física escolar. Este estudo etnográfico, que contou com observação participante e entrevistas, seguiu os atores que fizeram parte da constituição da agência antidopagem brasileira. Os resultados mostraram que a noção de ética e de saúde perpassaram os interesses dos atores da antidopagem, sendo parte dos discursos das instituições antidopagem, fazendo, assim, com que seja alvo de debate no campo da Educação Física e da escola.
A Resolução de Problemas: experiência e avaliação nessa perspectiva
Authors: Silva Costa Silvânia Da , Jesus Robson Andrade de , Souza Wagner Santiago de
Published: March 2021

O presente artigo aborda questões inerentes à metodologia de Resolução de Problemas e uma experiência de avaliação, levando em consideração apreensões e atitudes do educando frente ao processo de resolução de problemas propostos. Tentamos também sentir a experimentação não só do ponto de vista do professor, mas também do discente, centro do processo educativo. Os autores apresentam estudo de caso elaborado a partir de questionário aplicado com discentes do 9° ano do Colégio de Aplicação/UFS. O objetivo é refletir sobre os caminhos percorridos por estes durante o processo de resolução da situação-problema proposta, observando-se os procedimentos desenvolvidos na escrita e interpretação de problemas matemáticos. A análise mapeia as dificuldades e potencialidades apresentadas pelos estudantes na resolução de problemas matemáticos, bem como sua percepção enquanto “resolvedores de problemas”.
Clinical Outcomes of Post Renal Transplant Patients with COVID-19 Infection: A single-center case series
Authors: Maheboob Shaikh , Khatib Mohamad , Alwraidat Mohammad , Ananthegowda Dore , Abdallah Muftah , Aroos Asra , Jujjavarapu Sagar , Banerjee Saptarshi , Nasir Zishan , Mohamed Ahmed soliman , Elshafei Moustafa , Nashwan Abdulqadir
Published: March 2021

Post renal transplant patients are generally immunosuppressed and remain
at a higher risk for getting bacterial and viral infections. Most of
these patients are taking immunosuppressive medications, including
steroids. This case series highlights the clinical outcomes and
characteristics of 8 post renal transplant patients who acquired
COVID-19.
Reinforcement-based cognitive biases as vulnerability factors in alcohol addiction: From humans to animal models
Authors: Noworyta Karolina , Cieslik Agata , Rygula Rafal
Published: March 2021

Alcohol use disorder (AUD) is one of the most common but still poorly
treated psychiatric conditions. Developing new treatments requires a
better understanding of the aetiology of symptoms and evaluation of
novel therapeutic targets in preclinical studies. Recent developments in
our understanding of the reinforcement-based cognitive biases (RBCBs)
that contribute to the development of AUD and its treatment offer new
opportunities for both clinical and preclinical research. In this
review, we first briefly describe psychological and cognitive theories
that implicate various aspects of reinforcement sensitivity in the
development, maintenance, and recurrence of alcohol addiction.
Furthermore, in separate sections, we describe studies investigating
RBCBs and their neural, neurochemical, and pharmacological correlates,
and we discuss possible interactions between RBCBs and trajectories of
AUD. Finally, we describe how recent translational studies using
state-of-the-art animal models can facilitate our understanding of the
role of reinforcement sensitivity and RBCBs in various aspects of AUD.
Glucagonostatic Potency of GLP-1 in Patients With Type 2 Diabetes, Patients With Type 1 Diabetes, and Healthy Control Subjects
Authors: Bagger Jonatan I. , Grøndahl Magnus F.G. , Lund Asger , Holst Jens J. , Vilsbøll Tina , Knop Filip K.
Published: March 2021

Hyperglucagonemia is a well-known contributor to diabetic hyperglycemia, and glucagon-like peptide 1 (GLP-1) suppresses glucagon secretion. Reduced inhibitory effects of glucose and GLP-1 on glucagon secretion may contribute to the hyperglucagonemia in diabetes and influence the success of GLP-1 receptor agonist therapy. We examined the dose-response relationship for GLP-1 on glucose-induced glucagon suppression in healthy individuals and patients with type 2 and type 1 diabetes. In randomized order, 10 healthy individuals with normal glucose tolerance, 10 patients with type 2 diabetes, and 9 C-peptide–negative patients with type 1 diabetes underwent 4 separate stepwise glucose clamps (five 30-min steps from fasting level to 15 mmol/L plasma glucose) during simultaneous intravenous infusions of saline or 0.2, 0.4, or 0.8 pmol GLP-1/kg/min. In healthy individuals and patients with type 2 diabetes, GLP-1 potentiated the glucagon-suppressive effect of intravenous glucose in a dose-dependent manner. In patients with type 1 diabetes, no significant changes in glucagon secretion were observed during the clamps whether with saline or GLP-1 infusions. In conclusion, the glucagonostatic potency of GLP-1 during a stepwise glucose clamp is preserved in patients with type 2 diabetes, whereas our patients with type 1 diabetes were insensitive to the glucagonostatic effects of both glucose and GLP-1.
Manifesto De’VIA de 1989
Authors: Vieira Neves Gabriele
Published: March 2021

O presente estudo tem como objetivo analisar o Manifesto De’VIA (Deaf View/Image Art) como uma declaração política da comunidade surda no campo epistemológico das artes visuais. Para isso, utilizou-se o documento produzido em 1989 por um grupo de artistas surdos dos Estados Unidos, no qual estão descritas as características da arte De’VIA, bem como, o seu propósito político. Utilizou-se como referencial teórico os estudos sobre linguagem, política e subjetividade de autores como Jacques Ranciére, Michel Foucault e Gilles Deleuze. Após a tradução e leitura do documento, percebeu-se que o manifesto De’VIA explora a potência das artes visuais como dispositivo de subjetivação política dos sujeitos surdos e reconfigura a partilha do sensível, onde os surdos historicamente ocuparam o lugar de sujeitos sem voz e sem palavra. Concluiu-se que o movimento pode ser compreendido como uma batalha no campo da linguagem, uma vez que seu documento de fundação propõe a desnaturalização do termo genérico “arte surda” e sua substituição pelo termo De’VIA, uma palavra criada pela junção da língua americana de sinais e da língua inglesa.
Escrevivências do corpo(política)fronteiriço
Authors: Cavalcante de Oliveira Leite Viviani , Nolasco Edgar Cézar
Published: March 2021

Este trabalho faz parte de um projeto maior (projeto de pesquisa de doutorado pelo PPGEL - Programa de Pós Graduação em Estudos de Linguagens) propõe uma teorização epistêmico-conceitual acerca da escrevivência (conceito cunhado pela escritora mineira Conceição Evaristo) respaldada pelos conceitos de exterioridade e fronteira por meio de uma teorização que emerge a partir da (MIGNOLO) fronteira geoistórica, conceitual e epistemológica e vai além do que a epistemologia moderna acampou afim de (des)arquivar (DERRIDA) as histórias (bio)locais que foram suprimidas, excluídas e invisibilizadas por ela. A ideia centralizadora do ocidentalismo excluiu e desprezou qualquer ser/saber/pensar que não fosse o do “modelo”, assim, os saberes e sujeitos fronteiriços foram excluídos e ficaram de fora por destoarem do padrão moderno do sistema-mundo. Esse discurso hegemônico, moderno e colonial da ordem da interioridade, criou a exterioridade e relegou os sujeitos/saberes fronteiriços para este lugar, este beco/lugar de despejo marginal a partir do qual, em contraproposta ao projeto ocidentalista, (re)surgem os seres/saberes/pensares fronteiriços. Valeremo-nos de uma epistemologia de cunho crítico biográfico fronteiriço, uma vez que pensamos a partir de lócus e de corpos específicos. Assim, as escrituras negras serão pertinentes para ilustrar tal teorização conceitual. A metodologia do presente trabalho será de caráter eminentemente bibliográfico, desenvolvida, dentre outros, por críticos como Walter Mignolo e Edgar Cézar Nolasco, através dos conceitos de exterioridade, desobediência epistêmica, fronteira, corpopolítica e geopolítica.
Palavras-chave:  Escrevivência; exterioridade; fronteira; desobediência epistêmica.
…А ВОТ НАБЛЮДАТЕЛЬ ТУТ КАК РАЗ И НИ ПРИ ЧЕМ!
Authors: Ашшурский Эмир
Published: March 2021

В данной статье автор подвергает последовательной критике весьма неуклюжие попытки современных естествоиспытателей хоть как-то аргументировать пресловутый парадокс Ферми. Шутка ли кому сказать: в своих громоздких, но зачастую бессмысленных конструкциях некоторые астрофизики доходят даже до того, что ничтоже сумняшеся меняют местами причину со следствием!

Да это, впрочем, и немудрено: ведь, как говаривал блаженной памяти Козьма Прутков, «специалист подобен флюсу, ибо полнота его - одностороння». Короче говоря, заключительный вывод напрашивается, очевидно, тут уж сам собой: решение наиболее сложных и запутанных проблем космологии лучше, конечно же, доверять философам, а не технарям!
Multi Selection Control Algorithm in Examination Invigilation Management System(ExIMS) for Exchanging Invigilation Duties Among Invigilators at UiTM Pulau Pinang Branch
Authors: Othman Jamal bin , Syed Abdullah Sharifah Sarimah , Samsudin Norshuhada , Wan Mohd Rosly Wan Nur Shaziayani
Published: March 2021

Invigilation of the examination is one of the important roles and tasks of lecturers appointed as invigilators or proctors. Based on the past semi-annually reports of examination post-mortems meeting, less than 10% of the invigilators were unhappy with the examination duties that have been assigned or appointed to them. The examination committee members who are responsible in the process of assigning the invigilation duties to each invigilator had given a lot of effort and spent a few weeks to ensure that everybody is happy with the invigilation duties assigned to them. Nevertheless, despite the excellent planning of invigilation duties assignment, it cannot make everybody satisfied. Thus, a web-based application system named Examination Invigilation Management Systems (ExIMS) has been developed using the System Development Life Cycle (SDLC) waterfall model methodology to meet the need of invigilation duties exchanged among invigilators or applicants. This system has been developed to control and cross check the request of invigilation duties exchanged using the algorithm named multi selection control. The algorithm could avoid any conflicts or anomalies that could happen after the exchange of duty has been made. The process of duty exchange is examined and verified automatically by the system. The system provides a platform for users or invigilators to give their views or opinions on the invigilation duties and system features or performance through the online survey. The survey uses the TAM method concentrating on the perceived-ease-of-use (PEOU) component. Based on the survey, 95% respondents reported that they were satisfied with the platform for duty exchange among invigilators. The users can easily and flexibly select the new duties, which will be automatically and mutually swapped among invigilators. ExIMS has solved the problem of unsatisfaction of invigilation duties and increased the happiness index among invigilators during the examination period.
THE IMPACT OF MASS MEDIA AND SOCIAL NETWORKS ON HOW FANS INTERACT WITH SPORTS LIBRARIES IN THE WORLD
Authors: Kiani Mohammad Saed , Nazari Leila , Shahbazpour. Leila
Published: March 2021

Background and Aim: The purpose of this study was to investigate the impact of mass media and social networks on the relationship between fans and sports librarians in the world. Method: In this study, to investigate the role of new media and social networks on the interactions between fans and sports librarians, the role of new media on how fans interact with sports libraries from the review of the research carried out from 2009 onwards. Regarding the use of sports media, given that the category of modern media is a new concept, quantitative research has been conducted on its impact on sport, the creation of jobs, the promotion of communication, and the limited research on the negative effects of these media. The study was followed by a manual review of the studies conducted over the period without such results. Findings: It is not that all interactions between fans of athletes and coaches in the new media are positive. The growing interaction that has emerged between these groups today can have negative aspects. The results showed that the negative aspects of the new media have affected all life's moments of athletes and coaches. Negative tweets are so bad in some cases that most athletes and coaches are forced to turn off their communication devices. Conclusion: It seems that with the development of new media and social networks the wall between athletes, coaches and fans is collapsing and it is possible for new connections between these two groups to be created, this new relationship has a lot of positive and negative effects, although the organization sports exercises allow for a better experience for fans.
Comparative Study of Seismic Response of Short Columns Retrofitted by Steel Jacket, brick wall and FRP Fiber
Authors: Al-Mudhafer Amjad
Published: March 2021

Using inter-frame walls sometimes leads to the structure fortification in time of earthquake, but sometimes leads to plastic joint in the column which leads to the structure destruction. Therefore, the purpose of this work is to study and retrofit columns of inter-frame walls of deficient two-story structure, where he was taken in this research four models (Simple, With brick, With FRP, With Steel Jacket). In this work we look for the best retrofitting state of columns of half inter-frame wall by different states of retrofitting including FRP fibers and steel jackets. The analytical method used in this research is nonlinear elastic analysis by ABAQUS Software program. The results were extracted for the shear force with respect to the displacement of the static loads, and the displacement with respect to time was also extracted into the live loads of the four models. It was found that the presence of retrofitting of short shafts using steel jacket and FRP leads to a 3-40% increase in concrete bending framework in the section of shear strength and earthquake resistance.