bluuebunny/crossref_metadata_2025 huggingface dataset:
EDUCAÇÃO EM SAÚDE E ATENÇÃO FISIOTERAPÊUTICA NO PÓS-OPERATÓRIO DE CÂNCER DE MAMA
Authors: Russi Zequiela C. , Sudbrack Edite  Maria
Published: January 2022

Devido à elevada incidência e o alto impacto gerado pelo câncer de mama esta morbidade é tratada como um problema de saúde pública. No Brasil, inúmeros programas, sistemas e ações foram criados neste âmbito, porém tratando-se das sequelas geradas pela doença e tratamento, não ficam claras as abordagens enquanto políticas públicas de atenção fisioterapêuticas de educação em saúde. Assim, este estudo objetivou identificar se as práticas de atenção fisioterapêuticas, enquanto educação em saúde no pós-operatório do câncer de mama, interferem no tempo de afastamento laboral. Valeu-se de pesquisa descritiva, de caráter qualitativo e quantitativo, portanto, mista. Como resultados observou-se que existem muitos trabalhos sobre o tema Educação em Saúde, entretanto, escassos, sobre a questão da fisioterapia na educação destes pacientes e sobre o impacto socioeconômico causado por esta patologia. Conclui-se, assim, que é necessário ampliar o diálogo provocado pelo impacto socioeconômico dos afastamentos laborais nos casos de câncer de mama, reforçando a importância da educação para promover a saúde, a qual deve ser um fator de integração entre diversos setores do governo, nas diferentes esferas, articulando políticas e ações que culminem com a melhoria das condições de vida da população.
Implementasi Pendekatan Andragogi Spiritual dalam Meningkatkan Motivasi Belajar Mandiri Mahasiswa pada Program Studi Pendidikan Bahasa Indonesia FKIP Universitas Muhammadiyah Banjarmasin
Authors: Hamidah Jamiatul , Syakir Akhmad
Published: January 2022

Metode perkuliahan yang dilakukan oleh dosen sangat berpengaruh terhadap hasil yang nantinya akan dicapai oleh mahasiswa, baik itu mencakup proses belajar-mengajar, penugasan, maupun pada saat ujian. Pendekatan andragogi spiritual memberikan kebebasan kepada mahasiswa untuk menumbuhkan kemandirian belajar, kesadaran terhadap pengembangan potensi diri, dan motivasi untuk meraih tujuan belajar. Penelitian  ini  bertujuan untuk mendeskripsikan penerapan pendekatan andragogi spiritual dalam perkuliahan untuk mengoptimalkan hasil belajar mahasiswa.  Penelitian ini menggunakan metode deskriptif dengan pendekatan kualitatif. Metode yang digunakan dalam pengumpulan data adalah wawancara dan pembagian angket terbuka kepada dosen dan mahasiswa.  Sumber data diperoleh dari 40 orang mahasiswa dan 6 orang dosen pada Program Studi Pendidikan Bahasa Indonesia, FKIP, Universitas Muhammadiyah Banjarmasin. Hasil penelitian menunjukkan bahwa penerapan pendekatan andragogi spiritual dapat meningkatkan motivasi dan hasil belajar mahasiswa. Pendekatan andragogi spiritual merupakan sebuah pendekatan pembelajaran bagi orang dewasa yang menekankan pada spirit atau kejiwaan peserta didik pada tingkat dewasa. Pada Program Studi Pendidikan Bahasa Indonesia, penerapan pendekatan ini dilakukan di berbagai aspek dengan berlandaskan penanaman nilai Al-Islam Kemuhammadiyahan. Penerapan tersebut dilakukan oleh dosen mulai dari persiapan pembelajaran, proses kegiatan pembelajaran, sampai kegiatan penilaian atau evaluasi.
Growth and survival of Clarias catfish (Clarias gariepnus B., 1822) at different stages of cultivation with the addition to the fodder of “Chiktonik”
Authors: Kovalenko Bohdan , Kovalenko Vasyl , Sharylo Dmytro , Polishchuk Nadiia , Korzh Olha , Kirakosian Alina
Published: January 2022

Stressful situations decrease the growth rate and survival rate of fish, thus, the search for ways to reduce their adverse impact is relevant. The purpose of the research – to evaluate in aquaculture conditions the effect of different concentrations of vitamin-amino acid complex “Chiktonik” on the growth and survival of larvae and fry of African clarius catfish (Clarias gariepinus B., 1822) after stressful situations. The stressful situation for the fish arose from significant fluctuations in the content of ammonia, nitrites and nitrates in the water environment of the closed recirculation aqua system during the period of start-up of the biological filter, until the equilibrium was established. A series of experiments were performed, during which it was established that the addition of the drug at the rate of 1 ml per 1 kg of feed accelerates the growth of fish in experimental variants compared to the control. Experimental use of high doses of the drug (5, 15, 30 and 45 ml/kg of fodder) initially inhibited the growth of fish body weight, but 10-30 days after the experiment, the growth rate of the experimental material was equal to that of the control group of fish and even exceeded the control values in the future. The positive effect of the vitamin-amino acid complex “Chiktonik” on the survival of young clarius catfish at the stage of completion of the larval period of life and in the early stages of the fry period was established. In the experiment with older fish, which were fully developed fry, such an effect of the drug was not observed: the survival rate of fish was at the same level both in the experiment and in the control. Therewith, it was established that the fry reacted worse to higher doses of the drug compared to the grown larvae. The growth rate of fry after using high doses of the drug did not equal that of fish from the control group within a month after the experiment, unlike younger fish. In general, the expediency and safety of the practical use of the drug “Chiktonik” for young clarius catfish as a fodder additive at a dose of 1 ml/kg of fish fodder have been proved
Quality of queen bees in different ways of their production
Authors: Kucheriavyi Vitalii , Salyuk Oleksandr , Skrypnyk Serhii
Published: January 2022

Timely replacement of queens is one of the main zootechnical methods for maintaining the vital activity of bee families, and searching for ways to improve their quality is an urgent problem. The purpose of this study was to evaluate the effect of the method of obtaining queen bees of Apis mellifera sossimai and Apis mellifera carpatica breeds on their reproductive functions and bee family productivity. To conduct research in the conditions of the apiary of honey-pollination area, three groups were established - control and two experimental, with nine bee colonies in each. In the first (control) group, uteruses were artificially removed from the nursery, in the second group - fistula uteri and the third – swarm uteri. The apiary was located at a point of 50×50 meters, bee families were kept in hives. According to the results of the study, it was established that the queen bee Apis mellifera carpatica was heavier than the queen bee Apis mellifera sossimai. The queen bees from the nursery are the smallest, and the swarm queen bees are slightly heavier than in other groups, although the difference was not statistically significant. Fistula queen bees produce the most eggs and provide the best brood quality. Fistula queen bees have better weight uniformity than swarm bees, which affects the productivity of families. Colonies with swarm queen bees are characterised by different levels of development, which complicates the maintenance of these families. The quality of queens is affected by the breeding method and the location of the queen cell in the honeycomb. The more queens the colony grows, the worse their quality. As it is complicated to establish optimal conditions in the nursery and the number of queen cells is large, this is the reason for the worst quality of queens. The results obtained are of practical importance for choosing a method of rearing queen bees of high quality to establish well-developed bee colonies
Effects of Low Estrogens: Vaginal Atrophy
Authors: Gupta PD
Published: January 2022

Estrogens are the group of hormones which makes a woman a woman. Girls at menarche start making it and under normal conditions sufficient levels are maintained in the women's body until menopause. During perimenopause, menopause and postmenopause the hormone levels start fluctuating and if maintained low for a longer period, it starts giving various problems. Fluctuating levels of estrogen causes, hot flashes, night sweats, vaginal dryness, depression, and mood swings. Sleep disturbances brain fog and may be heart disease, osteoporosis, obesity and the appearance of unwanted facial hair. These problems can be overcome by supplementing with phytoestrogens or hormone replacement therapy.
Women Health Awareness, Acquisitions, and Partnerships to Bring New Era for Contraceptive Drugs.
Authors: Gujrathi Ashish
Published: January 2022

The spread of COVID-19 and the resulted lockdown imposed across the globe has negatively affected the contraceptive drugs market. Many women across the world found it hard to purchase the pills as contraceptive drug manufacturers were facing challenges due to inconsistent supply chains and the workforce.
Vulvar Craurosis due to Severe Genitourinary Syndrome of Menopause Complicated by Lichen Sclerosus: Two Case Reports and Literature Review
Authors: Pérez Febles Marta , Pascual Escudero Victoria , De Miguel Manso Sonia , López Pais María , Viruega Cuaresma Dakota , Suárez Mansilla Paula
Published: January 2022

Background: Vulvovaginal atrophy aﬀects approximately 45% of middle-aged women, as a result of decreased estrogen circulating levels and is often associated with vulvovaginal discomfort in menopausal patients. The spectrum of adverse consequences makes long-term treatment essential, not only for symptom relief, but also to avoid further complications. These symptoms can even be worsened if other vulvar conditions coexist, such as inflammatory dermatoses. Clinical presentation: We present two cases of patients with severe vulvar atrophy and craurosis, who required vulvo-vaginal opening associated with medical treatment. In both patients, we diagnosed severe genitourinary syndrome of menopause (GSM) complicated by vulvar lichen sclerosus, a very rare clinical situation. In case 1, the symptoms had progressed despite local estrogen treatment for vulvovaginal atrophy, and lichen wasn’t considered in previous check-ups. In contrast, patient nº 2 presented in the ER with impossibility to urinate and was then diagnosed and treated for underlying causes. Conclusions: GSM treatment should be a priority. The absence of improvement or progression of genital atrophy should alert the specialist to the coexistence of other vulvar pathologies.
A Homeopathic Treatment İn a Female Patient with İnfertility
Authors: Alp Hayriye
Published: January 2022

There is a physiological balance between our systems in our body. When this physiological balance is disturbed, diseases ocur. Infertility; It is defined as not having a pregnancy despite the couples having regular sexual intercourse. Homeopathy, a natural remedy that has been used widely all over the world for 200 years system. It has been recognized by the World Health Organization (WHO) as the second largest treatment method used worldwide. Although it is the most popular form of treatment in India and South America, it is also used by over 30 million people in Europe and millions of other people around the world. A female patient 33 years old who applied to Getat Polk for infertility had also divorsed from her first marriage for 8 years due to infertility. She continued her infertility treatment during her marriage. Tsh 1.93Uıu/ml, t3 3,05 pg/ml,t4 0.76ng/dl. Glukose 82mg/ml, d vitamine 8ng/ml, b12 270pg/ml, total cholesterol 176mg/ml, creatinine 0.63mg/dl tg 77 mg/dl fe 38ug/dl AST 19 U/L E stradiole 46ug/l LH 12,42IU/L Ferritine 8.51 ug/l hemoglobine 11.8g/dl .After a detailed anamnesis, the patient was started on Hyos c30 2*1, Ignatia c30 2*1, and folliculunum c200 2*1 (1st and 14th days of menstruation) in December 2020. The patient was 7 weeks pregnant in september 2021.β-Hcg 15000Mıu/ml Fe 171 ug/dl. Hormonal balance in women is very sensitive and easily effected, either by endogen or exogen disturbances. Pressure and suppression induced by dominant forces on an individual such as dominant parents, husband, harassment at work or religions dominance can be a cause to create a so called Folliculinum state, as well as results from immune system suffering after long lasting and profound infection, which is suppressed by medication.
Study Inhibitory Effect of Alhagi Extract on Oral Microorganisms
Authors: Mohammed Alsewidi Wasan
Published: January 2022

Many studies determined effect of plant extract on plant pathogens and human pathogens. Alhagi maurorum is considered as one of the important medicinal plants in Iraq. It is used for urinary tract infection, rheumatic pains and liver disorders. Study the Inhibition Effect of Alhagi extract on oral microorganisms as Streptococci, Actinobacillus and Staphylococci, with (0, 10, 50 and 100 percentages). The concentrations of 0% has not any inhibition effect, 10%, has a slight inhibition effect against oral Streptococci and Actinobacillus, but has not effect on Staphylococci. 50%, has an inhibition effect against oral Streptococci more than E-coli, but has not effect on Staphylococci, but 100%, has a wide inhibition effect a against oral Streptococci more than Actinobacillus except Staphylococci has not effect. The lack of inhibition effect at the concentration of 0% and 10% of Alhagi maurorum aqueous extract may be returned to the limits or decline of active components in these low concentrations of aqueous extract. In addition, studies indicate that there are many factors have an effect in the minimizing the impact of plant extracts.
Combined PGT for Breast Cancer and Other Inherited Conditions
Authors: Rechitsky Svetlana , Pakhalchuk Tatiana , Prokhorovich Maria , Kuliev Anver
Published: January 2022

Inherited cancer predisposition is presently one of the major indications for preimplantation genetic testing (PGT), providing an option for couplers at risk to avoid the birth of an offspring with predisposition to cancer. We present here our experience of 35 of 874 PGT cycles for cancer, in which in addition to BRCA1/2 the couples were at risk to another genetic conditions as well, for which PGT was performed together with PGT for breast cancer. This resulted in in birth of 20 mutation free children with not only unaffected for the tested genetic condition, but also without risk of developing cancer. This is a part of our overall PGT series of 6,204 PGT cases for monogenic disorders (PGT-M), with 2,517 resulting births, free of genetic disorder. The accumulated experience, demonstrates considerable progress in using PGT for avoiding the birth of affected children together with avoiding predisposition to cancer.
Clinical - Psychological and Psychotherapeutic Intervention
Authors: Aliyev NA , Aliyev ZN
Published: January 2022

The purpose of this work was to general familiarize psychiatrists with various aspects and directions of psychotherapeutic methods. It is common knowledge that most couple psychiatrists ignore the value of psychotherapy. This article indicates the importance of psychotherapy in the practice of psychiatrists. A good knowledge of psychotherapeutic methods is necessary for modern and high-quality provision of mental health care to the population.
Combination of Clomipramine and Carbamazepine for Treatment of Patients with Methamphetamine Dependence
Authors: Aliyev NA , Aliyev ZN
Published: January 2022

Objective: There are few new approaches to the pharmacotherapeutic treatment of methamphetamine dependence in the literature. The publications contain abundant data on various methods of pharmacotherapeutic treatment of methamphetamine dependence. However, no pharmacotherapeutic therapy for methamphetamine dependence is sufficient. Materials and Methods: This was a double-blind study in patients diagnosed with methamphetamine dependence according to DSM-5. A total of 100 patients who met the DSM-5 criteria for methamphetamine dependence were examined. All male patients from 18 to 60 years old. The patients were divided into two groups of 50 people: the first group received clomipramine (anafranil) 300 mg / day (100 mg 3 times a day) and carbamazepine 600 mg / day (200 mg 3 times a day) orally. The second group received an indifferent drug (placebo) Results: as shown by follow-up data (12 months), among 50 patients who received anaphrani and carbamazepine only, 10 had short-term breakdowns associated with exposure to microsocial causes. The rest of the patients were in remission. Among patients receiving placebo, only 5 patients experienced remission, all the rest had cases of relapse. Responder analysis was performed using chi-square (x2) and analysis of variance (ANOVA). Conclusion. Clinical statistics indicate the high efficiency of the use of anaphrani and carbamazepine in the treatment of methamphetamine dependence. The mechanisms of action of the drug are being discussed.
Atypical Femur Fracture in the Setting of Long-Term Bisphosphonate use for Osteogenesis Imperfecta: A Case Report
Authors: J. Prusick Parker , D. Jones Jr. Steven , Roberts Jesse , Donaldson Nathan
Published: January 2022

Bisphosphonate (BP) therapy for moderate to severe osteogenesis imperfecta (OI) has become a mainstay of treatment in the last three decades. Given the significant improvements in bone mineral density and theoretical reductions in fracture risk, many patients are treated with bisphosphonates for prolonged periods of time. There currently lacks consensus in the optimal duration of BP therapy for patients with OI, and patients are often treated on a case-by-case basis. Long-term BP therapy has been associated with atypical femur fractures in adult patients treated for osteoporosis. The American Society for Bone and Mineral Research concluded that the median duration of BP therapy in patients with atypical femur fractures was 7 years. The role of long-term BP therapy in OI patients with atypical femur fractures remains unclear. Here, a case report is presented of an adolescent patient with type V OI that sustained a subtrochanteric femur fracture with features of an atypical pattern following treatment with intravenous pamidronate for 10.5 years. At the time of injury, the contralateral femur was also found to have atypical features suggestive of an impending fracture. The completed fracture was treated with closed reduction and cephalomedullary nail fixation. The impending fracture was prophylactically stabilized using the same technique. Prior to the injury, limb-length radiographs obtained to evaluate lower extremity alignment demonstrated features of an impending fracture but went unnoticed. Further studies are needed to clarify the role of long-term BP therapy in patients with OI suffering from atypical femur fractures.
Our Acupuncture Experıences in Patıents with Remarkable Leg Syndrome: Pilot Study
Authors: Alp Hayriye
Published: January 2022

Restless legs syndrome (RLS) is a disease characterized by an undescribable abnormal sensation, a kind of dysesthesia, especially in the legs. It is characteristic for restless legs syndrome that the symptoms are circadian in nature, that is, they are more pronounced in the evening and at night, and occur or increase at rest. In response to these effects, when the effects of acupuncture on various systems and symptoms and the mechanisms of these effects are evaluated, the benefits of acupuncture in restless legs syndrome may be the subject of research. This study was carried out on patients who applied to Konya Necmettin Erbakan University Meram Medical Faculty Traditional and Complementary Medicine Center with the complaints of restless legs syndrome. In addition, nothing was requested from the participants. Informed consent form was obtained. Both body and ear acupuncture were applied for 10 sessions once a week. ST-33,34,35,GB-34, H-7LU-9,P-6,SI-3 points and shen-men,zero,knee on the ear , depression points were pricked. Electro acupuncture was applied for 20 minutes.) Pittsburgh sleep quality index scale questionnaire and john hopkins scale were applied to the participants before and after acupuncture. .Pittsburgh sleep quality index mean pre-acupuncture:35.5.Post acupuncture Pittsburgh sleep quality index mean:24. With the application of acupuncture, progress can be made in the treatment of restless legs syndrome that does not respond to conventional treatment.
Healthy Living in Makassar’s Family Based on Thier Faith
Authors: Agussalim Agussalim , Saleng Muhammad , Hermansyah Hermansyah , Kusuma Ardhanari Hendra , Bahruddin Bahruddin , Natsir M , Abidin Abidin
Published: January 2022

Various aspects of human life are organized in Muslim community, including health problems. Islam highly upholds the health in which many people are deceived from such health. One of the efforts that can be done to maintain the health given by god is to implement clean and Healthy Living Behavior in families, schools and others. This research was conducted at Mosque of Antang, Makassar. This research was conducted using Cross Sectional design. The sample used as many as 40 respondents; data analysis used is univariate and bivariate with chi-square test. The results of statistical tests of Hand Washing Orders and defecation obtained a value of p Value of 0.000, and Smoking Prohibition obtained a value of p Value of 0.001, the test results showed that there is a relationship between Hand Washing Orders, defecation and Smoking Prohibition with Clean and Healthy Living Behavior, because the calculated value of P < α = 0.05. Based on the research, it can be concluded that Clean and Healthy Living Behavior of Applied Mosque Antang is in the good category. Where they are washing Their Hands, Make Latrines and without Smoking because of the encouragement of faith in their hearts, fear and obedience to the command of God and the magnitude of their love for the Messenger. Therefore, it is expected through this research that the People of Indonesia to further increase faith and following to god and love and practice of the Messenger of God in daily life.
The amphoteric cartilage surface tested in the pH Range from 2.0 to 9.0
Authors: Pawlak Zenon , Sojka Michal
Published: January 2022

Background: Phospholipids adsorbed to negatively-charged proteoglycan matrix form phospholipid (membrane), have negatively charged surface (-PO4-) and are hydrophilic. Strong adsorption and strong cohesion are necessary for phospholipids to provide a good lubricant. The surface energy of spherical lipid bilayers have "bell-curve" shaped has amphoteric character and lowest surface energy at a pH 7.4 ± 1 of the natural joint. Objectives: The amphoteric character of the natural surface of the articular cartilage was determined by measuring the surface energy of the model spherical bilayer lipid membrane. It was found that the friction (f) vs. pH 2.0 to 9.0 of the pair (cartilage/cartilage) has the amphoteric character by exposing "bell-curve" shaped with an isoelectric point (IEP). Methods: The friction coefficient (f) was measured with the sliding pin-on-disc tribotester the friction between two surfaces (cartilage/cartilage) pair. The method of interfacial tension measurements of the spherical lipid bilayer model vs the pH over the range 0.2 to 9.0 was used. Results: The dependence of friction coefficient between two cartilage surfaces on the pH over the range 2.0 to 9.0 is demonstrated by a “bell - curve” in Fig. 2(A). The surface energy of a model spherical bilayer lipid membrane vs. the pH has the character of a “bell - curve” with an (IEP) is shown in Fig. 2(B). Conclusion: The amphoteric effect on friction between the bovine cartilage/cartilage contacts has been found to be highly sensitive to the pH of an aqueous solution. In this paper we demonstrate experimentally that the pH sensitivity of cartilage to friction provides a novel concept in joint lubrication on charged surfaces. The change in friction was consistently related to the change of charge density of an amphoteric surface.
Van Lohuizen Syndrome, a Late-Diagnosed Case in an 18 Years-Old Female
Authors: Aljayar Abdulrahim
Published: January 2022

Cutis Marmorata Telangiectatica Congenita is a very rare birth defect involving cutaneous blood vessels. Of unknown cause, uncertain pathophysiology, unclear epidemiology. Described as a localized, or generalized marbled skin appearance (cutis marmarota), in addition to the skin, it may involve any other body organs, with, or without a wide variety of associated congenital anomalies.Kato van Lohuizen described the first case in 1922. Since then, there have been less than 300 cases reported worldwide to date. We are adding one more case, and the first reported in Libya.
Clinical Pharmacology of Rocuronium in Infants and Children
Authors: Pacifici Gian Maria
Published: January 2022

The main clinical use of the neuromuscular blocking agents is an adjuvant in surgical anaesthesia to obtain relaxation of skeletal muscle, particularly of the abdominal wall, to facilitate surgical manipulations. Rocuronium can be used instead of suxamethonium to provide rapid muscle paralysis during tracheal intubation but the recovery is much slower. Rocuronium is administered intravenously to infants and children. In infants, rocuronium is administered at a dose of 450 µg/kg for providing muscle relaxation for laryngeal intubation. To provide sustained paralysis, rocuronium is given at a dose of 600 µg/kg. In children, the neuromuscular blockade is obtained with 600 µg/kg followed by an intravenous infusion of 150 µg/kg per hour. For assisted ventilation in intensive care, rocuronium is administered at a dose of 600 µg/kg followed by an intravenous infusion of 300 to 600 µg/kg per hour. The effects of rocuronium have been extensively studied in infants and children. Rocuronium is converted into 17-desacetyl rocuronium. The pharmacokinetics of rocuronium have been studied in infants and children and the mean residence time is 55.6 and 25.6 min (P-value < 0.01) in infant and children, respectively. Rocuronium interacts with drugs, the treatment of infants and children with rocuronium has been studied, and rocuronium poorly crosses the human placenta. The aim of this study is to review the published data on rocuronium dosing, pharmacokinetics, and treatment in infants and children, and rocuronium metabolism and transfer across the human placenta.
Clinical differentiation of Migraine, Cervicocephalic Syndrome and Meniere's Disease
Authors: Saberi Behzad
Published: January 2022

Meniere's disease, cervicocephalic syndrome and migraine are relatively common pathologies. It is important for the clinicians to make difference between these pathologies in clinical settings. This is a brief review on the important clues to differentiate these pathologies from each other to make the diagnosis of each one of these pathologies easier.
Pearls of plastics in ENT practice that Conceals & Camouflages the Camber, Contour & Cosmesis in Facial Trauma
Authors: Basavannaiah Sphoorthi
Published: January 2022

Facial trauma can involve soft tissue injuries such as burns, lacerations, bruises and even fractures of the facial bones such as nasal fractures and fractures of the jaw as well as injury to the eye. Symptoms are specific to the type of injury that can be either signs of inflammation or changes in facial definition. Facial injuries have the potential to cause temporary deviations in facial delineation to permanent disfigurement of facial structures.
Ameliorative Effects of Fenugreek Seeds and Curcumin on Hematotoxicity induced by Nicotine in Male Albino Rats
Authors: Elsayed Azab Azab , Omar Albasha Mohamed , Abuelkasem Elnaif Manal
Published: January 2022

The present study aimed to investigate the ameliorative effects of fenugreek seeds and curcumin on hematotoxicity induced by nicotine in male albino rats. 30 male F-344/NHsd Fischer rats, weighing from 180 to 200g were used in the present study. The animals were divided into five groups (6 rats for each); Group I (control group), Group II (nicotine treated group), Group III (nicotine/fenugreek seeds co-administered), Group IV (nicotine/curcumin co-administered), and Group V (nicotine/curcumin& fenugreek seeds co-administered). At the end of the experimentation and 24 hours after the last dose, all animals were anaesthetized with ether and blood samples were collected by heart puncture. The samples were collected in clean dry tubes containing the anticoagulant substance EDTA and used for the hematological studies. The results showed that the animals treated with nicotine for 4 weeks showed a significant decrease in RBCs count, hemoglobin concentration, hematocrit value, MCH, MCHC, and platelets count, and increased MCV and WBCs count as compared to the control group. Co-administration of nicotine with fenugreek and/or curcumin caused improvement in all hematological parameters when compared with nicotine group. It can be concluded that nicotine had a strong effect on the hematological parameters. The ingestion of fenugreek and/or curcumin prevent the hematoxicity induced by nicotine. The current study suggests that fenugreek and curcumin may be useful in combating free radical-induced hematotoxicity induced by nicotine.
Stepwise Cerebral Ischemia Causes Disturbances in Mitochondrial Respiration of Neurons in the Cerebral Cortex of Rats
Authors: L.I Bon , N.Ye Maksimovich , I.K. Dremza , Maria A Lychkovskaya
Published: January 2022

Objectives: To conduct a comparative analysis of respiration of mitochondria of brain homogenates of rats with stepwise subtotal cerebral ischemia with different duration between ligations of both common carotid arteries. Methods: The experiments were performed on 24 male mongrel white rats weighing 260 ±20 g. Cerebral ischemia (CI) was simulated under intravenous thiopental anesthesia (40-50 mg/kg). The control group consisted of falsely operated rats of similar sex and weight. To study mitochondrial respiration, the brain was extracted in the cold (0-4°C), dried with filter paper, weighed and homogenized in an isolation medium containing 0.32 M sucrose, 10 mM Tris-HCl, 1 mM EDTA, pH 7.4 (in a ratio of 1:10), using Potter-Evelheim homogenizer with Teflon pestle according to the modified method. To prevent systematic measurement errors, brain samples from the compared control and experimental groups of animals were studied under the same conditions. Results: Stepwise SCI with an interval of 1 and 3 days between bandages of both OCA leads to damage to the neurons of the parietal cortex and hippocampus of rats, which manifests itself in a decrease in their size, deformation of the pericaryons, an increase in the number of shrunken neurons and shadow cells. The most pronounced changes were observed in the subgroup with an interval between dressings of 1 day. These changes were similar to the changes in SCI (p>0.05), except for the absence of cells with pericellular edema in the hippocampus and a smaller number of them in the parietal cortex. SCI with an interval between WASP dressings of 7 days, on the contrary, it is manifested by less pronounced histological changes, especially in the hippocampus. Conclusion: In cerebral ischemia, damage to the inner mitochondrial membrane occurs due to activation of free radical oxidation processes. Damage to the inner mitochondrial membrane, in turn, leads to an increase in its permeability and a decrease in the level of the proton gradient due to the transition of protons along the concentration gradient through the resulting nonspecific pores into the mitochondrial matrix. As a result, the efficiency of ATP synthesis decreases, and more substrates and oxygen are required to maintain the intermembrane potential under these conditions.
High Cell Density Cultivation of Escherichia coli DH5α in Shake Flasks with a New Formulated Medium
Authors: Ng Wenfa
Published: January 2022

High cell density cultivation necessitates cell division and biomass formation, the mechanisms of which remain poorly understood, especially from the cellular energetics perspective. Specifically, the sensing of energy abundance and the channelling of nutritional energy into biomass formation and cell maintenance remains enigmatic at the sensory, effector and decision levels. Thus, optimization of cell growth remains an iterative trial and error process where the principal parameters are growth medium composition and incubation temperature. In this study, a new semidefined formulated medium was shown to be useful for high cell density cultivation of Escherichia coli DH5α (ATCC 53868). Comprising K2HPO4, 12.54; KH2PO4, 2.31; D-Glucose, 4.0; NH4Cl, 1.0; Yeast extract, 12.0; NaCl, 5.0; MgSO4, 0.24; the medium possessed a high capacity phosphate buffer able to moderate pH fluctuations during cell growth known to be detrimental to biomass formation. With glucose and NH4Cl providing the nutrients for initial growth, followed by a lag phase of 3 hours, a maximal optical density of 12.0 was obtained after 27 hours of cultivation at 37 oC and 230 rpm. Yeast extract provides a secondary source of carbon and nitrogen. Maximal optical density obtained in formulated medium was higher than the 10.1, 4.2, and 3.4 obtained in Tryptic Soy Broth, M9 with 1 g/L of yeast extract, and LB Lennox, respectively. Cultivation of E. coli DH5α in formulated medium with 6 g/L of glucose resulted in a longer lag phase of 8 hours and a longer time (68 hours) to attainment of maximal optical density, which marked the upper limit of glucose concentration beyond which biomass formation would be reduced. Specifically, glucose concentration above 6 g/L markedly reduced biomass formation possibly due to the environmental stress arising from low pH in the culture broth. Glucose concentration below 4 g/L, on the other hand, reduced biomass formation through a smaller pool of nutrients serving as biomass building blocks. Deviation from 1:1 molar ratio between glucose and NH4Cl was not detrimental to biomass formation and growth rates. Collectively, a semi-defined formulated medium could increase optical density of E. coli DH5α beyond that of LB Lennox and Tryptic Soy Broth, and may find use in cultivation of cells for applied microbiology research.
Insight into secondary metabolites of Stachybotrys, Memnoniella, Doratomyces and Graphium between benefits and harmful
Authors: A. Elkhateeb Waill , M. Daba Ghoson
Published: January 2022

Stachybotrys, Memnoniella, Doratomyces and Graphium all these genera belonging to Class: Sordariomycetes. This review is to demonstrate description, ecology, and secondary metabolites from Stachybotrys, Memnoniella, Doratomyces and Graphium and some of their reported biological activities. Besides, describing the importance and potentials of those fungi in order to encourage for further studies to each genus metabolites and purify already known metabolites.
Botryotrichum and Scopulariopsis Secondary Metabolites and Biological Activities
Authors: A. Elkhateeb Waill , M. Daba Ghoson
Published: January 2022

Botryotrichum and Scopulariopsis are a fungal genera that belongs to Class: Sordariomycetes. This review is to demonstrate secondary metabolites from Botryotrichum and Scopulariopsis and some of their reported biological activities. Moreover, describing the unique chemical diversity of these fungal genera involved in medical, pharmaceutical, agricultural applications. Also highlight the harmful side of these fungi if present.
Brand Association and Sales Growth: A Study of Nigeria the Flour Milling Industry
Authors: Adeoye Itunuoluwa , Ayodele O.E  , Adesuyi I.O  , Ayo M.F
Published: January 2022

Branding has developed in the minds of customers a strong and positive perception of a company's products or services. However, most of these businesses struggle to use branding strategy to differentiate themselves from competition and grow sales. The goal of this study is to assess the impact of brand association tactics on the sales growth of flour milling enterprises. The major technique of data collection was administered questionnaire to the sales and marketing employees of the selected flour milling enterprises in Lagos State. The findings indicated that brand connections have a positive and considerable impact on sales growth. The study recommends that brand managers should also ensure that customers' interactions with the brand remain consistent in order to generate sales growth.
Rebranding of Arnetta Craft’s product in Malaka Sari, East Jakarta
Authors: Dwianti Agustina , Tamboto Afourli Daven , Syafitri Alya Gustriani , Slamet Angeline Calista , Larasati Anisa , Nada Ativa Kannuri , Putri Baharini Kurnia , Epseen Epseen , Ong Jarell , Caesar Leo Andri Yulius , Winata Nadia Ingrida , Ermando Nikolas , Putri Nuril Kusumawardani Soeprapto , Prasojo Ricky , Rahma Safira Fauzia , Candra Sevenpri , Kristianti Sheren , Heripracoyo Sulistyo , Bahariawan Sulthan , Karima Syamila , Carnika Wenny , Febrian Zidan
Published: January 2022

The role of society is very important in maintaining the balance of nature. The community empowerment approach is the success key in educating the surrounding environment. Arnetta Craft is a community empowerment presenting in Malaka Sari, East Jakarta. Arnetta Craft continuously invites all levels of society caring about the results of household waste, especially used cooking oil. Processed products from household waste produce a useful product for people's daily needs and have commercial selling value. However, with the existing competition, the marketing approach needs to be improved by creating logos, labeling and product packaging. To be able to produce logos, labeling and product packaging, a structured interview was conducted with the owner of Arnetta Craft. At the end of the activity, new logos, labeling and packaging have been produced used as product rebranding.
Promotional training through outdoor advertisements and digital media publications
Authors: Junaedi Fajar , Sukmono Filosa Gita
Published: January 2022

SD Muhammadiyah Kalangan is located in Baturetno Village, Banguntapan, Bantul, Yogyakarta Special Region. The location of SD Muhammadiyah Kalangan is actually strategic because it is on the border of Bantul Regency, Yogyakarta City and Sleman Regency, however the competition is very tight. Within a 5-kilometer radius, there are at least 7 schools, both public and private elementary schools. The location of SD Muhammadiyah Kalangan is far from the highway, so the name of the school is not known to the public. In online mass media, the name SD Muhammadiyah Kalangan also appears very rarely. In fact, the publication of school activities in online mass media is important. Based on these two issues, this service program will focus on increasing school promotion through outdoor advertising and publications in the mass media. Activities are carried out with advertising workshops and digital media publications. This activity produces school advertisements in the form of outdoor advertisements and publications in digital media as school promotion media.
Implementation of marketing strategy 4.0 to pastry producers in Taman District, Sidoarjo Regency
Authors: Sulistiyowati Indah , Akbar Ali , Latifah Fitri Nur
Published: January 2022

The COVID-19 pandemic has caused Danish Cake SMEs to experience a decline in turnover of up to 30%. This is due to the focus on offline product marketing, both through agents and resellers. While the pandemic has changed the way of shopping, most consumers prefer online shopping, because it is considered safer and minimizes direct contact with sellers. The problem-solving method used is to optimalize the marketing 4.0 strategy that combines offline and online interactions between producers and customers. For online channels, the service team created a shopping application via an Android phone as a virtual shopping facility and created a paspastry.com website which also functions as a customer database. With this application, consumers just shop through their respective cellphones, choose the desired cake, make a payment, and the cake will be sent to the buyer's house. Another use of online channels is to improve promotional content through Instagram, Facebook, and fanpages as well as by creating accounts on marketplaces such as Shopee. With the implementation of the Marketing 4.0 strategy, Danish Cake SMEs will increase their product sales, both online and offline, in addition to increasing branding awareness of the product.
Efforts to prevent and break the chain of the spread of Covid-19 in Universitas Muhammadiyah Magelang
Authors: Muliawanti Lintang , Sulistyono Muhammad Ridwan , Nugroho Nalendra Bagas Adi , Hanafi Muhammad A , Wahyuningtyas Anisa , Rindiyani Rindiyani
Published: January 2022

The Covid-19 volunteer task force program at the Universitas Muhammadiyah Magelang (Unimma) aims to prevent and break the chain of the spread of COVID-19 in the campus environment. There are several methods, including screening, surveillance, as well as media publications and promotions. The results of the Unimma Covid-19 volunteer task force program obtained surveillance results with one suspect, three probable and no confirmed patients, close contact and discarded. In addition, the academic community at Unimma understands the importance of health protocols and is supported by the creation of poster materials posted on campus and social media Instagram and YouTube.
Caring for the community affected by the Covid-19 pandemic in Mataram Sei Putih Village, Riau
Authors: Hasibuan Vincent Natanael , Rahman Ari , Sari Mega Mutiara , Qonitan Fatimah Dinan , Ulhasanah Nova , Sarwono Ariyanti , Sofiyah Evi Siti , Zahra Nurulbaiti Listyendah , Ridhosari Betanti , Suryawan I Wayan Koko
Published: January 2022

The Covid-19 pandemic has a direct impact on public health and indirectly on the environment and the community's economy. One of the areas that has had the greatest impact is Sei Putih, Riau. The occurrence of massive layoffs caused the ability of the community to purchase food needs to be quite low. The purpose of this activity is to provide socialization of health protocols and the provision of basic necessities to the needs. The socialization of health protocols was carried out so that during the distribution of groceries there would not be a crowded crowd. During the socialization, people are also required to wear masks and wash their hands. The food items were given on April 4, 2021. The basic food items were 5 kg of rice, 1 L of cooking oil, 1 can of sardines, 2 packs of Indomie, and 500 grams of sugar. From the range of 1-5, the assessment of program is 4.65 and satisfaction is 4.8. This shows that the activity is very good to be carried out to foster awareness in the community.
Dissemination of corn sheller machines to increase productivity and efficiency for corn farmer associations in Wonogiri Regency
Authors: Haikal Haikal , Margono Bambang , Chamim Moch , Surya Yudis Adhana , Febriawan Zulkarnaen Ryeda , Putra Rendi Yanwar Perdana , Wiyono Apri
Published: January 2022

Corn is a superior agricultural product for the Giri Harjo I farmer group, Girikikis Village, Giriwoyo District, Wonogiri. However, farmers process and peel corn manually, so it takes a more time and inefficient. In order to overcome this problem, this community service designed and made a corn sheller machine that was used to simplify and increase the productivity in the corn harvesting process. This service activity begins with the delivery of the corn sheller machine to the farmer group, then exposure and training on the use of the machine. Corn shelling is accomplished by inserting the corn into the sheller shaft, after which the grinding knife separates the corn kernels from the cob. The shelling test results show that this machine works well, is practical to use, is highly portable, the production process is faster, the corncobs are not damaged, and the electric power consumption is low. This machine has a 0.5 HP motor and a production capacity of 183 kg/hour for shelling corn kernels.
Realizing a healthy pregnancy through optimizing the participation in pregnant women class
Authors: Fajrin Fitriana Ikhtiarinawati , Khusna Naila Shofa Nida’ul
Published: January 2022

This community service aims to increase knowledge, change attitudes and behavior of mothers to understand pregnancy, body changes, complaints during pregnancy, pregnancy care, childbirth, postpartum care, postnatal family planning, newborn care, and myths to achieve a healthy pregnancy. The method of the community service is health education in the form of pregnant women class and demonstrations of pregnant gymnastics practices which are carried out at the Sumberagung Village Hall, Sukodadi District, Lamongan Regency. The results indicate an increase in knowledge of pregnant women related to information about pregnancy and childbirth. Thus, pregnant women have an awareness of the importance of taking classes for pregnant women and make it a necessity to realize a healthy pregnancy.
Empowerment of youth care about reproductive health in the covid-19 pandemic era
Authors: Pristya Terry Y.R. , Herbawani Chahya Kharin , Karima Ulya Qoulan , Oktafiyanti Arnur , Ramadhanty Nadia
Published: January 2022

Adolescence is a transition period of human life. Various problems were experienced at that time, especially regarding reproductive health. During the COVID-19 pandemic, youth groups and posyandu activities were stopped. There were many activities previously made by the youth, including joint sports, joint dawn, and Friday night recitations. This shows that there are no activities related to reproductive health. Therefore, the purpose of this community service is to form youth care about reproductive health. The service activities are carried out through 6 stages, starting with discussions with partners about the importance of youth activities in the Covid-19 pandemic, and continued by forming a youth care team. The community service provided knowledge about adolescent reproductive health, socialization of 3 BKKBN modules, training in making handbooks, and the election of ambassadors for adolescent reproductive health. The results are the formation of adolescents who care about reproductive health, increased knowledge, and reproductive health handbooks.
Training on making liquid dish soap in Lembah Sari Village, Rumbai Timur District, Pekanbaru
Authors: Surya Alfin , Juariah Siti , Sidoretno Wahyu Margi , Tisnawan Rahmat
Published: January 2022

Peningkatan pengetahuan terhadap perempuan terutama dibidang ekonomi adalah salah satu parameter membaiknya kesejahteraan keluarga. Saat perempuan menjadi kaum terdidik dan memiliki kreatifitas sehingga mempunyai pendapatan mandiri maka kesejahteraan keluarga dapat meningkat. Selain itu ibu-ibu juga memiliki peran yang berarti dalam hal pencegahan dan pengendalian kemiskinan melalui kegiatan pemberdayaan masyarakat.  Salah satu bukti bahwa wanita atau perempuan juga dapat meningkatkan kesejahteraan keluarganya dengan melakukan kegiatan produktif di dalam rumah tangga. PKK RT 02 RW 06 Kelurahan Lembah Sari merupakan salah satu organisasi perempuan yang memiliki latar belakang Pendidikan beragam (lulusan SLTA dan Perguruan Tinggi), dan Sebagian besar ibu rumah tangga dengan keadaan ekonomi keluarga menengah. Untuk mencukupi kebutuhan sehari-hari, ibu-ibu ini mengandalkan pendapatan suami namun ada juga yang bekerja sebagai guru atau membuat kue untuk membantu kebutuhan perekonomian keluarga. Pada saat kondisi pandemi seperti ini dengan pengeluaran untuk kebutuhan keluarga yang semakin meningkat, maka dilakukan kegiatan pengabdian masyarakat ini. Tujuan kegiatan ini adalah meningkatkan pengetahuan dan kreatifitas ibu-ibu PKK untuk membuat sabun cair cuci piring, sehingga menumbuhkan kesadaran dan kemandirian dalam berusaha, sekaligus memperluas lapangan kerja guna meningkatkan pendapatan keluarga dalam usaha mencapai keluarga yang bahagia dan sejahtera. Sabun cuci piring merupakan komoditas yang tidak bisa dipisahkan dari kebutuhan rumah tangga. Kegiatan ini dilakukan diawali pada hari Minggu, 14 Maret  2021 pada jam 08.00 WIB sampai dengan jam 12.00 WIB, bertempat di halaman rumah salah satu warga dengan peserta 17 orang ibu-ibu PKK.  Dampak yang dapat dilihat pada kegiatan ini adalah tumbuhnya semangat peserta untuk memiliki produk sendiri dan mendaftarkan izin edarnya. Sehingga kegiatan pengabdian ini sangat diterima oleh peserta dan memberikan pengetahuan baru bagi peserta