bluuebunny/crossref_metadata_2025 huggingface dataset:
Figure S7 from The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis
Authors: Taylor Sarah E. , O'Connor Caitlin M. , Wang Zhizhi , Shen Guobo , Song Haichi , Leonard Daniel , Sangodkar Jaya , LaVasseur Corinne , Avril Stefanie , Waggoner Steven , Zanotti Kristine , Armstrong Amy J. , Nagel Christa , Resnick Kimberly , Singh Sareena , Jackson Mark W. , Xu Wenqing , Haider Shozeb , DiFeo Analisa , Narla Goutham
Published: March 2023

Supplemental data for the investigation of growth inhibition induced by SMAP treatment in EMCA
Supplementary Methods and Fig s1-s13 from A Novel MYCN-Specific Antigene Oligonucleotide Deregulates Mitochondria and Inhibits Tumor Growth in MYCN-Amplified Neuroblastoma
Authors: Montemurro Luca , Raieli Salvatore , Angelucci Silvia , Bartolucci Damiano , Amadesi Camilla , Lampis Silvia , Scardovi Anna Lisa , Venturelli Leonardo , Nieddu Giammario , Cerisoli Lucia , Fischer Matthias , Teti Gabriella , Falconi Mirella , Pession Andrea , Hrelia Patrizia , Tonelli Roberto
Published: March 2023

Figure S1: BGA002 induces apoptosis Figure S2: BGA002 inhibits MYCN expression in a broad neuroblastoma cell-line panel Figure S3: BGA002 is a specific MYCN inhibitor Figure S4: Mitochondria structural alteration are MYCN specific inhibition. Figure S5: BGA002 leads to MYCN-specific structural alteration in mitochondria. Figure S6: BGA001 does not lead to significant MYCN-specific structural alteration in mitochondria. Figure S7: MYCN inhibition leads to mitochondrial damage Figure S8: Alterations in mitochondrial pathways identify Neuroblastoma patients with poor prognosis. Figure S9: MYCN amplified patient are enriched for the mitochondrial gene signature. Figure S10: MYCN blocking leads to MYCN specific gene expression signature inhibition in NB cells and to mitophagy reactivation. Figure S11: OPTN controls mitophagy induction after MYCN silencing Figure S12: BGA002 reverts the MYCN control of ROS generation by TRAP1 down-regulation in MNA-NB cells. Figure S13: BGA002 causes elimination of MYCN-NB in mice
Figure S4 from The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis
Authors: Taylor Sarah E. , O'Connor Caitlin M. , Wang Zhizhi , Shen Guobo , Song Haichi , Leonard Daniel , Sangodkar Jaya , LaVasseur Corinne , Avril Stefanie , Waggoner Steven , Zanotti Kristine , Armstrong Amy J. , Nagel Christa , Resnick Kimberly , Singh Sareena , Jackson Mark W. , Xu Wenqing , Haider Shozeb , DiFeo Analisa , Narla Goutham
Published: March 2023

Supplemental data for the classical and enhanced sampling molecular dynamics simulations
Figure S3 from The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis
Authors: Taylor Sarah E. , O'Connor Caitlin M. , Wang Zhizhi , Shen Guobo , Song Haichi , Leonard Daniel , Sangodkar Jaya , LaVasseur Corinne , Avril Stefanie , Waggoner Steven , Zanotti Kristine , Armstrong Amy J. , Nagel Christa , Resnick Kimberly , Singh Sareena , Jackson Mark W. , Xu Wenqing , Haider Shozeb , DiFeo Analisa , Narla Goutham
Published: March 2023

Supplemental data evaluating for disruption of PP2A holoenzyme assembly in a cell-free binding assay system
Supplementary Data from Metformin Inhibits Progression of Head and Neck Squamous Cell Carcinoma by Acting Directly on Carcinoma-Initiating Cells
Authors: Wu Xingyu , Yeerna Huwate , Goto Yusuke , Ando Toshinori , Wu Victoria H. , Zhang Xuefeng , Wang Zhiyong , Amornphimoltham Panomwat , Murphy Anne N. , Tamayo Pablo , Chen Qianming , Lippman Scott M. , Gutkind J. Silvio
Published: March 2023

supplementary methods and figure legends
Figure S4 from Metformin Inhibits Progression of Head and Neck Squamous Cell Carcinoma by Acting Directly on Carcinoma-Initiating Cells
Authors: Wu Xingyu , Yeerna Huwate , Goto Yusuke , Ando Toshinori , Wu Victoria H. , Zhang Xuefeng , Wang Zhiyong , Amornphimoltham Panomwat , Murphy Anne N. , Tamayo Pablo , Chen Qianming , Lippman Scott M. , Gutkind J. Silvio
Published: March 2023

Representative flow cytometry plots of the frequency of CD44+ and ALDH1+ cells upon metformin treatment
Supplementary Methods, Figure S1, Figure S2, Figure S3, Figure S4, Figure S5, Figure S6, Figure S7, Figure S8, Table S1, Table S2, Table S3, Table S4 from Mas Receptor Activation Slows Tumor Growth and Attenuates Muscle Wasting in Cancer
Authors: Murphy Kate T. , Hossain Mohammed I. , Swiderski Kristy , Chee Annabel , Naim Timur , Trieu Jennifer , Haynes Vanessa , Read Suzannah J. , Stapleton David I. , Judge Sarah M. , Trevino Jose G. , Judge Andrew R. , Lynch Gordon S.
Published: March 2023

This file contains: â€¢ Supplemental Methods â€¢ Supplemental Figure S1. Muscle-specific overexpression of the AT1 but not the MasR regulates skeletal muscle fiber size in healthy mice. â€¢ Supplemental Figure S2. Representative images of differentiated C2C12 myotubes incubated for 48 h in normal horse serum and treated with vehicle control or the ACE/Ang II/AT1 axis activators Ang II or A779 â€¢ Supplemental Figure S3. Genetic MasR overexpression was induced by transducing C2C12 myoblasts with a Tet-regulated MasR lentivirus or empty lentivirus and treating differentiated myotubes with doxycylin â€¢ Supplemental Figure S4. Low dose AVE 0991 induces small but significant improvements in food and water intake and weight loss in severely cachectic C-26 tumor-bearing mice â€¢ Supplemental Figure S5. Low dose AVE 0991 (1 mg/kg) causes an oxidative-to-glycolytic shift in fiber types in TA muscles from severely cachectic C-26 tumor-bearing mice â€¢ Supplemental Figure S6. High dose AVE 0991 treatment enhanced cumulative water intake and movement as assessed by the number of beam breaks in severely cachectic C-26 tumor-bearing mice fed ad libitum but not in those pair-fed to vehicle treated controls â€¢ Supplemental Figure S7. Pharmacological Ang-(1-7)/MasR activation protects against Lewis Lung Carcinoma (LLC) cancer cell induced muscle fiber atrophy in vitro â€¢ Supplemental Figure S8. Specificity of our custom anti-AT1 peptide compared to a commercially available anti-AT1 antibody â€¢ Supplemental Table S1. Primers used to amplify AT1 and MasR genes â€¢ Supplemental Table S2. Human cancer cachexia study group characteristics â€¢ Supplemental Table S3. List of upregulated proteins in AVE 0991 treated serum starved myotubes â€¢ Supplemental Table S4. List of down regulated proteins in AVE 0991 treated serum starved myotubes
Supplementary Figure S6 from YAP1 Mediates Resistance to MEK1/2 Inhibition in Neuroblastomas with Hyperactivated RAS Signaling
Authors: Coggins Grace E. , Farrel Alvin , Rathi Komal S. , Hayes Colin M. , Scolaro Laura , Rokita Jo Lynne , Maris John M.
Published: March 2023

Figure S6 shows a motif analysis indicating TEAD1-4 consensus sites present at the MYCN gene locus.
Supplementary Figure S4 from YAP1 Mediates Resistance to MEK1/2 Inhibition in Neuroblastomas with Hyperactivated RAS Signaling
Authors: Coggins Grace E. , Farrel Alvin , Rathi Komal S. , Hayes Colin M. , Scolaro Laura , Rokita Jo Lynne , Maris John M.
Published: March 2023

Figure S4 shows that YAP-5SA overexpression induces trametinib resistance in NLF YAP1-/- neuroblastoma cell lines.
Supplementary Data from p53-Suppressed Oncogene TET1 Prevents Cellular Aging in Lung Cancer
Authors: Filipczak Piotr T. , Leng Shuguang , Tellez Carmen S. , Do Kieu C. , Grimes Marcie J. , Thomas Cynthia L. , Walton-Filipczak Stephanie R. , Picchi Maria A. , Belinsky Steven A.
Published: March 2023

Fig. S1. TET1 knockdown in NSCLC cell lines.
Supplementary Data from p53-Suppressed Oncogene TET1 Prevents Cellular Aging in Lung Cancer
Authors: Filipczak Piotr T. , Leng Shuguang , Tellez Carmen S. , Do Kieu C. , Grimes Marcie J. , Thomas Cynthia L. , Walton-Filipczak Stephanie R. , Picchi Maria A. , Belinsky Steven A.
Published: March 2023

Fig. S4. Induction of senescence in A549 cells by simultaneous TET1 depletion and p53 inhibition using alternative TET1 siRNA.
Supplementary Figure 1 from Natural Killer–Derived Exosomal miR-186 Inhibits Neuroblastoma Growth and Immune Escape Mechanisms
Authors: Neviani Paolo , Wise Petra M. , Murtadha Mariam , Liu Cathy W. , Wu Chun-Hua , Jong Ambrose Y. , Seeger Robert C. , Fabbri Muller
Published: March 2023

Characterization of extracellular vesicles and expression of NK cell markers in neuroblastoma patients
Supplementary Data from p53-Suppressed Oncogene TET1 Prevents Cellular Aging in Lung Cancer
Authors: Filipczak Piotr T. , Leng Shuguang , Tellez Carmen S. , Do Kieu C. , Grimes Marcie J. , Thomas Cynthia L. , Walton-Filipczak Stephanie R. , Picchi Maria A. , Belinsky Steven A.
Published: March 2023

Fig. S7. Growth inhibition and senescence in p53 mutated NSCLC cells caused by TET1 depletion induced with alternative siRNA in conjunction with chemotherapy.
Supplementary Data from FGF Trapping Inhibits Multiple Myeloma Growth through c-Myc Degradation–Induced Mitochondrial Oxidative Stress
Authors: Ronca Roberto , Ghedini Gaia C. , Maccarinelli Federica , Sacco Antonio , Locatelli Silvia L. , Foglio Eleonora , Taranto Sara , Grillo Elisabetta , Matarazzo Sara , Castelli Riccardo , Paganini Giuseppe , Desantis Vanessa , Cattane Nadia , Cattaneo Annamaria , Mor Marco , Carlo-Stella Carmelo , Belotti Angelo , Roccaro Aldo M. , Presta Marco , Giacomini Arianna
Published: March 2023

Single file with supplemental figures, methods, tables, legends: Figure S1: Effects of FGF blockade in MM; Figure S2: FGF inhibition induces oxidative stress-mediated apoptosis in MM cells; Figure S3: Mitochondrial oxidative stress is responsible for the antitumor activity exerted in vivo by FGF inhibition; Figure S4: Oxidative stress-induced apoptosis following FGF inhibition is c-Myc-dependent; Figure S5: Western blot analysis for caspase 3 activation in PBMCs compared to NSC12-sensitive patient-derived MM cells treated with NSC12 for 12 hours; Figure S6: Effects of FGF inhibition in BTZ-resistant KMS-11 cells; Figure S7: High doses of BTZ hamper basal and NSC12-induced c-Myc degradation; Table S1: List of Log2 2-fold down- or upregulated genes in KMS-11 cells after 6 and 12 hours of NSC12 6μM treatment; Table S2: Patient-derived MM cells treated with NSC12; Reagent table.
Supplementary Data from Recreational Physical Activity Is Associated with Reduced Breast Cancer Risk in Adult Women at High Risk for Breast Cancer: A Cohort Study of Women Selected for Familial and Genetic Risk
Authors: Kehm Rebecca D. , Genkinger Jeanine M. , MacInnis Robert J. , John Esther M. , Phillips Kelly-Anne , Dite Gillian S. , Milne Roger L. , Zeinomar Nur , Liao Yuyan , Knight Julia A. , Southey Melissa C. , Chung Wendy K. , Giles Graham G. , McLachlan Sue-Anne , Whitaker Kristen D. , Friedlander Michael , Weideman Prue C. , Glendon Gord , Nesci Stephanie , Investigators kConFab , Andrulis Irene L. , Buys Saundra S. , Daly Mary B. , Hopper John L. , Terry Mary Beth
Published: March 2023

e Table1 contains the minimum number of average metabolic equivalents (METs) per week required to be classified as physically active at baseline and in adolescence for a given age at baseline. eTable 2 presents the association of baseline and adolescent strenuous and moderate recreational physical activity with breast cancer risk in the Prospective Family Study Cohort (N=15,500).
Supplementary Table 3 from MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma
Authors: New Maria , Van Acker Tim , Sakamaki Jun-Ichi , Jiang Ming , Saunders Rebecca E. , Long Jaclyn , Wang Victoria M.-Y. , Behrens Axel , Cerveira Joana , Sudhakar Padhmanand , Korcsmaros Tamas , Jefferies Harold B.J. , Ryan Kevin M. , Howell Michael , Tooze Sharon A.
Published: March 2023

Growth assay data and qPCR for 116 siRNAs
Supplementary Figure and Table Legends from MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma
Authors: New Maria , Van Acker Tim , Sakamaki Jun-Ichi , Jiang Ming , Saunders Rebecca E. , Long Jaclyn , Wang Victoria M.-Y. , Behrens Axel , Cerveira Joana , Sudhakar Padhmanand , Korcsmaros Tamas , Jefferies Harold B.J. , Ryan Kevin M. , Howell Michael , Tooze Sharon A.
Published: March 2023

Supplementary legends for Figure 1-3 and Table 1-4
Supplementary Figure 2 from MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma
Authors: New Maria , Van Acker Tim , Sakamaki Jun-Ichi , Jiang Ming , Saunders Rebecca E. , Long Jaclyn , Wang Victoria M.-Y. , Behrens Axel , Cerveira Joana , Sudhakar Padhmanand , Korcsmaros Tamas , Jefferies Harold B.J. , Ryan Kevin M. , Howell Michael , Tooze Sharon A.
Published: March 2023

Validation summary for 11 top autophagy regulators
Supplementary Data from ACE: A Workbench Using Evolutionary Genetic Algorithms for Analyzing Association in TCGA
Authors: Gilmore Alan R. , Alderdice Matthew , Savage Kienan I. , O'Reilly Paul G. , Roddy Aideen C. , Dunne Philip D. , Lawler Mark , McDade Simon S. , Waugh David J. , McArt Darragh G.
Published: March 2023

Supplementary Data. Exported ACE outputs
Supplementary Data from CircFOXK2 Promotes Growth and Metastasis of Pancreatic Ductal Adenocarcinoma by Complexing with RNA-Binding Proteins and Sponging MiR-942
Authors: Wong Chi Hin , Lou Ut Kei , Li Youjia , Chan Stephen L. , Tong Joanna HM , To Ka-Fai , Chen Yangchao
Published: March 2023

Supplementary Information including Supplementary Methods, Supplementary Figures 1-10 and Supplementary Tables 1-3
Supplementary Data from Blocking SHH/Patched Interaction Triggers Tumor Growth Inhibition through Patched-Induced Apoptosis
Authors: Bissey Pierre-Antoine , Mathot Pauline , Guix Catherine , Jasmin Mélissa , Goddard Isabelle , Costechareyre Clélia , Gadot Nicolas , Delcros Jean-Guy , Mali Sachitanand M. , Fasan Rudi , Arrigo André-Patrick , Dante Robert , Ichim Gabriel , Mehlen Patrick , Fombonne Joanna
Published: March 2023

Supplementary Material and methods and figures. Supplementary Figure 1: SHH is overexpressed in Colon, Pancreatic and NSCL cancers. Supplementary Figure 2: SHH interference lead to cell death in LoVo colon cell line. Supplementary Figure 3: SHH interference does not involve CDON-induced cell death. Supplementary Figure 4: PtcDN and interference with SHH does not affect the SHH positive signaling. Supplementary Figure 5: SHH expression in HCT8 xenograft and tumor growth inhibition in SHH siRNA treated HCT8- engrafted mice. Supplementary Figure 6: Interference with SHH in LoVo colon cell line show tumor growth inhibition in vivo.
Figure S1 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
Authors: Girard Christophe A. , Lecacheur Margaux , Ben Jouira Rania , Berestjuk Ilona , Diazzi Serena , Prod'homme Virginie , Mallavialle Aude , Larbret Frédéric , Gesson Maéva , Schaub Sébastien , Pisano Sabrina , Audebert Stéphane , Mari Bernard , Gaggioli Cédric , Leucci Eleonora , Marine Jean-Christophe , Deckert Marcel , Tartare-Deckert Sophie
Published: March 2023

Mesenchymal signature of BRAFi resistant melanoma cells
Supplementary Table S4 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Authors: Eckhardt Bedrich L. , Cao Yuan , Redfern Andrew D. , Chi Lap Hing , Burrows Allan D. , Roslan Suraya , Sloan Erica K. , Parker Belinda S. , Loi Sherene , Ueno Naoto T. , Lau Peter K. H. , Latham Bruce , Anderson Robin L.
Published: March 2023

BMP4 and SMAD7 in clinical samples
Supplementary Table S1 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Authors: Eckhardt Bedrich L. , Cao Yuan , Redfern Andrew D. , Chi Lap Hing , Burrows Allan D. , Roslan Suraya , Sloan Erica K. , Parker Belinda S. , Loi Sherene , Ueno Naoto T. , Lau Peter K. H. , Latham Bruce , Anderson Robin L.
Published: March 2023

PCR primers
Supplementary Figure legends from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Authors: Eckhardt Bedrich L. , Cao Yuan , Redfern Andrew D. , Chi Lap Hing , Burrows Allan D. , Roslan Suraya , Sloan Erica K. , Parker Belinda S. , Loi Sherene , Ueno Naoto T. , Lau Peter K. H. , Latham Bruce , Anderson Robin L.
Published: March 2023

Legends for the four supplementary figures.
Supplementary Material S1 from A Tumor-in-Host DEB-Based Approach for Modeling Cachexia and Bevacizumab Resistance
Authors: Tosca Elena M. , Rocchetti Maurizio , Pesenti Enrico , Magni Paolo
Published: March 2023

Mathematical details about model formulation and list of model parameters and variables
Supplementary Table II from A Pygopus 2-Histone Interaction Is Critical for Cancer Cell Dedifferentiation and Progression in Malignant Breast Cancer
Authors: Saxena Meera , Kalathur Ravi K.R. , Rubinstein Natalia , Vettiger Andrea , Sugiyama Nami , Neutzner Melanie , Coto-Llerena Mairene , Kancherla Venkatesh , Ercan Caner , Piscuoglio Salvatore , Fischer Jonas , Fagiani Ernesta , Cantù Claudio , Basler Konrad , Christofori Gerhard
Published: March 2023

Excel File list of differentially expressed genes (DEGs)
Supplementary Table 2 from Truncated ASPP2 Drives Initiation and Progression of Invasive Lobular Carcinoma via Distinct Mechanisms
Authors: Schipper Koen , Drenth Anne Paulien , van der Burg Eline , Cornelissen Samuel , Klarenbeek Sjoerd , Nethe Micha , Jonkers Jos
Published: March 2023

GSK-296692 intervention study dosing overview
Supplementary Tables S1 and S2 from MEF2c-Dependent Downregulation of Myocilin Mediates Cancer-Induced Muscle Wasting and Associates with Cachexia in Patients with Cancer
Authors: Judge Sarah M. , Deyhle Michael R. , Neyroud Daria , Nosacka Rachel L. , D'Lugos Andrew C. , Cameron Miles E. , Vohra Ravneet S. , Smuder Ashley J. , Roberts Brandon M. , Callaway Chandler S. , Underwood Patrick W. , Chrzanowski Stephen M. , Batra Abhinandan , Murphy Meghan E. , Heaven Jonathan D. , Walter Glenn A. , Trevino Jose G. , Judge Andrew R.
Published: March 2023

Patient demographics
Supplementary Movie 2 from Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance
Authors: Uchihara Tomoyuki , Miyake Keisuke , Yonemura Atsuko , Komohara Yoshihiro , Itoyama Rumi , Koiwa Mayu , Yasuda Tadahito , Arima Kota , Harada Kazuto , Eto Kojiro , Hayashi Hiromitsu , Iwatsuki Masaaki , Iwagami Shiro , Baba Yoshifumi , Yoshida Naoya , Yashiro Masakazu , Masuda Mari , Ajani Jaffer A. , Tan Patrick , Baba Hideo , Ishimoto Takatsugu
Published: March 2023

Real-time imaging of AGS cells treated with CAF-CM in the ECM.
Supplementary Table 3 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome
Authors: Huang Wenjie , Navarro-Serer Bernat , Jeong Yea Ji , Chianchiano Peter , Xia Limin , Luchini Claudio , Veronese Nicola , Dowiak Cameron , Ng Tammy , Trujillo Maria A. , Huang Bo , Pflüger Michael J. , Macgregor-Das Anne M. , Lionheart Gemma , Jones Danielle , Fujikura Kohei , Nguyen-Ngoc Kim-Vy , Neumann Neil M. , Groot Vincent P. , Hasanain Alina , van Oosten A. Floortje , Fischer Sandra E. , Gallinger Steven , Singhi Aatur D. , Zureikat Amer H. , Brand Randall E. , Gaida Matthias M. , Heinrich Stefan , Burkhart Richard A. , He Jin , Wolfgang Christopher L. , Goggins Michael G. , Thompson Elizabeth D. , Roberts Nicholas J. , Ewald Andrew J. , Wood Laura D.
Published: March 2023

Sequencing Data Quality from Primary FFPE PDAC Samples
Supplementary Table 2 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome
Authors: Huang Wenjie , Navarro-Serer Bernat , Jeong Yea Ji , Chianchiano Peter , Xia Limin , Luchini Claudio , Veronese Nicola , Dowiak Cameron , Ng Tammy , Trujillo Maria A. , Huang Bo , Pflüger Michael J. , Macgregor-Das Anne M. , Lionheart Gemma , Jones Danielle , Fujikura Kohei , Nguyen-Ngoc Kim-Vy , Neumann Neil M. , Groot Vincent P. , Hasanain Alina , van Oosten A. Floortje , Fischer Sandra E. , Gallinger Steven , Singhi Aatur D. , Zureikat Amer H. , Brand Randall E. , Gaida Matthias M. , Heinrich Stefan , Burkhart Richard A. , He Jin , Wolfgang Christopher L. , Goggins Michael G. , Thompson Elizabeth D. , Roberts Nicholas J. , Ewald Andrew J. , Wood Laura D.
Published: March 2023

Evaluation of Sox9 Expression in PDAC Organoids
Figure S1 from SIRT1-Mediated Expression of CD24 and Epigenetic Suppression of Novel Tumor Suppressor miR-1185-1 Increases Colorectal Cancer Stemness
Authors: Wang Teh-Wei , Chern Edward , Hsu Chao-Wei , Tseng Kuo-Chang , Chao Hsiao-Mei
Published: March 2023

CSC-like genes were upregulated in CRC stemness cells.
Supplementary Figure 6 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome
Authors: Huang Wenjie , Navarro-Serer Bernat , Jeong Yea Ji , Chianchiano Peter , Xia Limin , Luchini Claudio , Veronese Nicola , Dowiak Cameron , Ng Tammy , Trujillo Maria A. , Huang Bo , Pflüger Michael J. , Macgregor-Das Anne M. , Lionheart Gemma , Jones Danielle , Fujikura Kohei , Nguyen-Ngoc Kim-Vy , Neumann Neil M. , Groot Vincent P. , Hasanain Alina , van Oosten A. Floortje , Fischer Sandra E. , Gallinger Steven , Singhi Aatur D. , Zureikat Amer H. , Brand Randall E. , Gaida Matthias M. , Heinrich Stefan , Burkhart Richard A. , He Jin , Wolfgang Christopher L. , Goggins Michael G. , Thompson Elizabeth D. , Roberts Nicholas J. , Ewald Andrew J. , Wood Laura D.
Published: March 2023

Impact of Culture with TGFβ Inhibitors on Organoid Invasion
Supplementary Data from Raman Spectroscopy Reveals That Biochemical Composition of Breast Microcalcifications Correlates with Histopathologic Features
Authors: Vanna Renzo , Morasso Carlo , Marcinnò Beatrice , Piccotti Francesca , Torti Emanuele , Altamura Davide , Albasini Sara , Agozzino Manuela , Villani Laura , Sorrentino Luca , Bunk Oliver , Leporati Francesco , Giannini Cinzia , Corsi Fabio
Published: March 2023

The supplementary data file contains detailed patient's characteristics including the number of MC detected for each sample, statistical significance calculations, classification and validation results, wide angle X-ray scattering (WAXS) diffractograms, WAXS and small angle X-ray scattering (SAXS) images, mean Raman spectra of different diagnostic categories, box-plot reporting phosphate peak position shift among diagnostic categories, loading of the first principal components emerging from PCA and correlation between Raman variables and a) age, b) BIRADS classification and c) MC size.
Supplementary Table 3 from P2X7 Receptor Activity Limits Accumulation of T Cells within Tumors
Authors: Romagnani Andrea , Rottoli Elsa , Mazza Emilia Maria Cristina , Rezzonico-Jost Tanja , De Ponte Conti Benedetta , Proietti Michele , Perotti Michela , Civanelli Elisa , Perruzza Lisa , Catapano Alberico L. , Baragetti Andrea , Tenedini Elena , Tagliafico Enrico , Falzoni Simonetta , Di Virgilio Francesco , Norata Giuseppe Danilo , Bicciato Silvio , Grassi Fabio
Published: March 2023

Supplementary Table 3
Supplementary Tables from Modeling Acquired Resistance to the Second-Generation Androgen Receptor Antagonist Enzalutamide in the TRAMP Model of Prostate Cancer
Authors: Cerasuolo Marianna , Maccarinelli Federica , Coltrini Daniela , Mahmoud Ali Mokhtar , Marolda Viviana , Ghedini Gaia Cristina , Rezzola Sara , Giacomini Arianna , Triggiani Luca , Kostrzewa Magdalena , Verde Roberta , Paris Debora , Melck Dominique , Presta Marco , Ligresti Alessia , Ronca Roberto
Published: March 2023

Supplementary Tables with parameters
Supplementary Materials and Methods from Modeling Acquired Resistance to the Second-Generation Androgen Receptor Antagonist Enzalutamide in the TRAMP Model of Prostate Cancer
Authors: Cerasuolo Marianna , Maccarinelli Federica , Coltrini Daniela , Mahmoud Ali Mokhtar , Marolda Viviana , Ghedini Gaia Cristina , Rezzola Sara , Giacomini Arianna , Triggiani Luca , Kostrzewa Magdalena , Verde Roberta , Paris Debora , Melck Dominique , Presta Marco , Ligresti Alessia , Ronca Roberto
Published: March 2023

Additional Material and Methods
Figure S10 from Extracellular-Regulated Protein Kinase 5-Mediated Control of p21 Expression Promotes Macrophage Proliferation Associated with Tumor Growth and Metastasis
Authors: Giurisato Emanuele , Lonardi Silvia , Telfer Brian , Lussoso Sarah , Risa-Ebrí Blanca , Zhang Jingwei , Russo Ilaria , Wang Jinhua , Santucci Annalisa , Finegan Katherine G. , Gray Nathanael S. , Vermi William , Tournier Cathy
Published: March 2023

This supplementary figure confirms that ERK5 ablation significantly reduces TAM density in melanoma metastases.
Supplementary Methods from Aquaporin-7 Regulates the Response to Cellular Stress in Breast Cancer
Authors: Dai Chen , Charlestin Verodia , Wang Man , Walker Zachary T. , Miranda-Vergara Maria Cristina , Facchine Beth A. , Wu Junmin , Kaliney William J. , Dovichi Norman J. , Li Jun , Littlepage Laurie E.
Published: March 2023

Supplemental Methods
Figure S3 from Aquaporin-7 Regulates the Response to Cellular Stress in Breast Cancer
Authors: Dai Chen , Charlestin Verodia , Wang Man , Walker Zachary T. , Miranda-Vergara Maria Cristina , Facchine Beth A. , Wu Junmin , Kaliney William J. , Dovichi Norman J. , Li Jun , Littlepage Laurie E.
Published: March 2023

Aquaporin-7 is required for breast tumor burden, metastasis, and metabolic reprogramming.
Supplementary Figure S1 from Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers
Authors: Mukhopadhyay Suman , Goswami Debanjan , Adiseshaiah Pavan P. , Burgan William , Yi Ming , Guerin Theresa M. , Kozlov Serguei V. , Nissley Dwight V. , McCormick Frank
Published: March 2023

NRF2-mediated pathway is upregulated in KRAS mutant PDAC
Supplementary Data from Cancer Cell–Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma
Authors: Tian Chenxi , Öhlund Daniel , Rickelt Steffen , Lidström Tommy , Huang Ying , Hao Liangliang , Zhao Renee T. , Franklin Oskar , Bhatia Sangeeta N. , Tuveson David A. , Hynes Richard O.
Published: March 2023

This is supplemental figure legends.
Supplementary Tables from Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches
Authors: Hebert Jess D. , Myers Samuel A. , Naba Alexandra , Abbruzzese Genevieve , Lamar John M. , Carr Steven A. , Hynes Richard O.
Published: March 2023

Supplementary Tables S1 through S5. Supplementary Table S1. Overview of nomenclature; Supplementary Table S2. Overview of tandem mass tag (TMT) assignment; Supplementary Table S3. shRNA sequences; Supplementary Table S4. sgRNA sequences; Supplementary Table S5. qPCR primers used.
Supplementary Figure 3 from CTGF Mediates Tumor–Stroma Interactions between Hepatoma Cells and Hepatic Stellate Cells to Accelerate HCC Progression
Authors: Makino Yuki , Hikita Hayato , Kodama Takahiro , Shigekawa Minoru , Yamada Ryoko , Sakamori Ryotaro , Eguchi Hidetoshi , Morii Eiichi , Yokoi Hideki , Mukoyama Masashi , Hiroshi Suemizu , Tatsumi Tomohide , Takehara Tetsuo
Published: March 2023

Supplementary Fig. 3. CTGF expression and secretion levels in hepatoma cells. CTGF mRNA and protein expression and concentration in the culture supernatant of hepatoma cell lines (A) and parental, mock-transfected, and CTGF-overexpressing PLC/PRF/5 cells (B). Cell lysates and culture supernatants were collected 72 hours after plating (N = 4-6 per group). In bar graphs, bars and top whiskers represent mean values and standard deviations, respectively. *p < 0.05 vs. PLC/PRF/5 cells.
Supplementary Figure 2 from CTGF Mediates Tumor–Stroma Interactions between Hepatoma Cells and Hepatic Stellate Cells to Accelerate HCC Progression
Authors: Makino Yuki , Hikita Hayato , Kodama Takahiro , Shigekawa Minoru , Yamada Ryoko , Sakamori Ryotaro , Eguchi Hidetoshi , Morii Eiichi , Yokoi Hideki , Mukoyama Masashi , Hiroshi Suemizu , Tatsumi Tomohide , Takehara Tetsuo
Published: March 2023

Supplementary Fig. 2. CTGF expression is regulated through the Ras/Mek/Erk pathway. (A-D) CTGF expression in liver cancer cell lines was evaluated after activation or inhibition of the Ras signaling pathway (N = 4 per group). Expression levels of CTGF and phosphorylated Erk and Akt and CTGF concentration in culture supernatants at the indicated time point after treatment with 100 ng/mL EGF in Kras wild-type Huh7 cells (A). Cells were serum-starved for 12 hours before the addition of EGF. Gene and protein expression of Ras and CTGF 72 hours after transfection of Kras siRNAs (#1 and #2) or control siRNA into Kras mutant-type HepG2 cells (B). Protein expression of p-Akt and p-Erk 3 hours after the addition of LY294002 (a PI3K inhibitor), U0126 (a Mek inhibitor) or FR180204 (an Erk inhibitor) at indicated doses (C). CTGF gene expression and cell viability in HepG2 cells 6 hours after the addition of inhibitors at indicated doses (D). Cell viability was evaluated using a WST-8 assay (N = 4 per group). (E) Correlation between the CTGF gene expression levels and single-sample gene set enrichment analysis (ssGSEA) enrichment scores of the Ras/Mek/Erk pathway in 220 samples of non-tumorous liver tissues. In bar graphs, bars and top whiskers represent mean values and standard deviations, respectively. *p < 0.05 vs. the control.
Figure S1 from Ablation of the Brca1–Palb2 Interaction Phenocopies Fanconi Anemia in Mice
Authors: Park Dongju , Bergin Stephen M. , Jones Dan , Ru Peng , Koivisto Christopher S. , Jeon Young-Jun , Sizemore Gina M. , Kladney Raleigh D. , Hadjis Ashley , Shakya Reena , Ludwig Thomas
Published: March 2023

Generation of the Brca1 L1363P knock-in mice
Supplementary Figure Legends from HDAC6 Inhibition Synergizes with Anti-PD-L1 Therapy in ARID1A-Inactivated Ovarian Cancer
Authors: Fukumoto Takeshi , Fatkhutdinov Nail , Zundell Joseph A. , Tcyganov Evgenii N. , Nacarelli Timothy , Karakashev Sergey , Wu Shuai , Liu Qin , Gabrilovich Dmitry I. , Zhang Rugang
Published: March 2023

Supplementary Figure Legends
Supplementary Figure 5 from Chromothripsis in Human Breast Cancer
Authors: Bolkestein Michiel , Wong John K.L. , Thewes Verena , Körber Verena , Hlevnjak Mario , Elgaafary Shaymaa , Schulze Markus , Kommoss Felix K.F. , Sinn Hans-Peter , Anzeneder Tobias , Hirsch Steffen , Devens Frauke , Schröter Petra , Höfer Thomas , Schneeweiss Andreas , Lichter Peter , Zapatka Marc , Ernst Aurélie
Published: March 2023

Copy-number plots and rainfall plots for the 11 patients with two tumors from the DKFZ-HIPO17 cohort
Supplementary Figure 3 from Chromothripsis in Human Breast Cancer
Authors: Bolkestein Michiel , Wong John K.L. , Thewes Verena , Körber Verena , Hlevnjak Mario , Elgaafary Shaymaa , Schulze Markus , Kommoss Felix K.F. , Sinn Hans-Peter , Anzeneder Tobias , Hirsch Steffen , Devens Frauke , Schröter Petra , Höfer Thomas , Schneeweiss Andreas , Lichter Peter , Zapatka Marc , Ernst Aurélie
Published: March 2023

Fusion genes in tumors with and without chromothripsis
Supplementary Data from The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production
Authors: Sausville Lindsay N. , Gangadhariah Mahesha H. , Chiusa Manuel , Mei Shaojun , Wei Shouzuo , Zent Roy , Luther James M. , Shuey Megan M. , Capdevila Jorge H. , Falck John R. , Guengerich F. Peter , Williams Scott M. , Pozzi Ambra
Published: March 2023

This file contains the primer sequence of CYP2C9* variants (Supplementary Table S1); the SNPs genotyped in the BioVU NSCLC study (Supplementary Table S2); quality control measures of SNPs in the BioVU NSCLC study (Supplementary Table S3); clinical and demographic description of NSCLC cases (Supplementary Table S4); the association of clinical and demographic variables with survival (Supplementary Table S5); the genotypes in the NSCLC cases (Supplementary Table S6); the spectra of CYP2C9* variants and the effect of arachidonic acid on CYP2C9* variant (Supplementary Figure S1); the association between CYP2C9* variants and platinum chemotherapy (Supplementary Figure S2).
Supplementary Methods from State-Transition Analysis of Time-Sequential Gene Expression Identifies Critical Points That Predict Development of Acute Myeloid Leukemia
Authors: Rockne Russell C. , Branciamore Sergio , Qi Jing , Frankhouser David E. , O'Meally Denis , Hua Wei-Kai , Cook Guerry , Carnahan Emily , Zhang Lianjun , Marom Ayelet , Wu Herman , Maestrini Davide , Wu Xiwei , Yuan Yate-Ching , Liu Zheng , Wang Leo D. , Forman Stephen , Carlesso Nadia , Kuo Ya-Huei , Marcucci Guido
Published: March 2023

In this supplement we provide additional data and methods to support our results. In particular, we show: details of our mouse model of AML; demonstrate the robustness of our state-space construction to normalization methods and gene selection criteria; compare dimension reduction methods; show bootstrap cross-validation of our predictions; compare hierarchical clustering with our state-space approach; and finally, provide full lists of differentially expressed genes and gene ontology (GO) term enrichment.
Supplementary Fig 1 from FGFR1 Is Critical for RBL2 Loss–Driven Tumor Development and Requires PLCG1 Activation for Continued Growth of Small Cell Lung Cancer
Authors: Kim Kee-Beom , Kim Youngchul , Rivard Christopher J. , Kim Dong-Wook , Park Kwon-Sik
Published: March 2023

A. Immunoblot for FGFR1, phosphorylated-FGFR1 (Tyr653/654), RBL2, phosphorylated-RBL2 (Ser672), E2F1, and E2F4 among human SCLC lines. ACTB blot verifies equal loading of total proteins. Arrows indicate specific bands. B. A hypothetical model of mechanisms regulating FGFR1 transcription. E2F1-driven FGFR1 transcription is suppressed by RBL2-E2F4 repressor complex. In the event of RBL2 loss or phosphorylation, E2F4 loses its ability to repress FGFR1, and E2F1 activates FGFR1 transcription.
Supplementary Table 1 from Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2
Authors: Mao Ninghui , Gao Dong , Hu Wenhuo , Gadal Sunyana , Hieronymus Haley , Wang Shangqian , Lee Young Sun , Sullivan Patrick , Zhang Zeda , Choi Danielle , Rosen Neal , Sawyers Charles L. , Gopalan Anuradha , Chen Yu , Carver Brett S.
Published: March 2023

List of most significantly differentially expressed genes following ERG knock-out.
Figure S5 from Microenvironmental Cues Determine Tumor Cell Susceptibility to Neutrophil Cytotoxicity
Authors: Gershkovitz Maya , Fainsod-Levi Tanya , Khawaled Saleh , Shaul Merav E. , Sionov Ronit V. , Cohen-Daniel Leonor , Aqeilan Rami I. , Shaul Yoav D. , Fridlender Zvi G. , Granot Zvi
Published: March 2023

Supplemental Figure S5. Metastatic seeding of BMP7 treated cells is not enhanced by neutrophil depletion in tumor baring mice. Representative images of lung associated GFP+ BMP7 treated cells in control (BMP7) and neutrophil depleted (BMP7 depletion) mice, 48 hrs following tail-vein injection.
Video S4 from ΔNp63-Regulated Epithelial-to-Mesenchymal Transition State Heterogeneity Confers a Leader–Follower Relationship That Drives Collective Invasion
Authors: Westcott Jill M. , Camacho Sharon , Nasir Apsra , Huysman Molly E. , Rahhal Raneen , Dang Tuyen T. , Riegel Anna T. , Brekken Rolf A. , Pearson Gray W.
Published: March 2023

Live imaging of SUM159O cells embedded in ECM containing fluorescent microbeads (blue) showing ECM reorganization through bead movement.
Supplementary Method S1 from MRI Distinguishes Tumor Hypoxia Levels of Different Prognostic and Biological Significance in Cervical Cancer
Authors: Hillestad Tiril , Hompland Tord , Fjeldbo Christina S. , Skingen Vilde E. , Salberg Unn Beate , Aarnes Eva-Katrine , Nilsen Anja , Lund Kjersti V. , Evensen Tina S. , Kristensen Gunnar B. , Stokke Trond , Lyng Heidi
Published: March 2023

DCE-MRI and digital histopathology
Supplemental Table ST4 from Linking Transcriptomic and Imaging Data Defines Features of a Favorable Tumor Immune Microenvironment and Identifies a Combination Biomarker for Primary Melanoma
Authors: Gartrell-Corrado Robyn D. , Chen Andrew X. , Rizk Emanuelle M. , Marks Douglas K. , Bogardus Margaret H. , Hart Thomas D. , Silverman Andrew M. , Bayan Claire-Audrey Y. , Finkel Grace G. , Barker Luke W. , Komatsubara Kimberly M. , Carvajal Richard D. , Horst Basil A. , Chang Rui , Monod Anthea , Rabadan Raul , Saenger Yvonne M.
Published: March 2023

Survival statistics for MIP, CD8/CD68, and Combination biomarkers in 53-patient Combination cohort.
Supplementary Figure S5 from Blocking Angiopoietin-2 Promotes Vascular Damage and Growth Inhibition in Mouse Tumors Treated with Small Doses of Radiation
Authors: Kallio Pauliina , Jokinen Elina , Högström Jenny , Das Suvendu , Heino Sarika , Lähde Marianne , Brodkin Jefim , Korhonen Emilia A. , Alitalo Kari
Published: March 2023

Supplementary Figure S5
Supplementary Figure S2 from Blocking Angiopoietin-2 Promotes Vascular Damage and Growth Inhibition in Mouse Tumors Treated with Small Doses of Radiation
Authors: Kallio Pauliina , Jokinen Elina , Högström Jenny , Das Suvendu , Heino Sarika , Lähde Marianne , Brodkin Jefim , Korhonen Emilia A. , Alitalo Kari
Published: March 2023

Supplementary Figure S2
Supplementary Methods from FTO-Dependent N6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling
Authors: Huang Hao , Wang Yinu , Kandpal Manoj , Zhao Guangyuan , Cardenas Horacio , Ji Yanrong , Chaparala Anusha , Tanner Edward J. , Chen Jianjun , Davuluri Ramana V. , Matei Daniela
Published: March 2023

Detailed information regarding materials and methods are included in this file.
Figure S6 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Authors: Voli Florida , Valli Emanuele , Lerra Luigi , Kimpton Kathleen , Saletta Federica , Giorgi Federico M. , Mercatelli Daniele , Rouaen Jourdin R.C. , Shen Sylvie , Murray Jayne E. , Ahmed-Cox Aria , Cirillo Giuseppe , Mayoh Chelsea , Beavis Paul A. , Haber Michelle , Trapani Joseph A. , Kavallaris Maria , Vittorio Orazio
Published: March 2023

Copper lowering drugs increased NK-mediated cell death in vitro
Figure S2 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Authors: Voli Florida , Valli Emanuele , Lerra Luigi , Kimpton Kathleen , Saletta Federica , Giorgi Federico M. , Mercatelli Daniele , Rouaen Jourdin R.C. , Shen Sylvie , Murray Jayne E. , Ahmed-Cox Aria , Cirillo Giuseppe , Mayoh Chelsea , Beavis Paul A. , Haber Michelle , Trapani Joseph A. , Kavallaris Maria , Vittorio Orazio
Published: March 2023

Effect of copper levels on PD-L1 expression and interferon stimulation in cancer cells
Supplementary Figures from Slow-Cycling Cancer Stem Cells Regulate Progression and Chemoresistance in Colon Cancer
Authors: Shiokawa Daisuke , Sakai Hiroaki , Ohata Hirokazu , Miyazaki Toshiaki , Kanda Yusuke , Sekine Shigeki , Narushima Daichi , Hosokawa Masahito , Kato Mamoru , Suzuki Yutaka , Takeyama Haruko , Kambara Hideki , Nakagama Hitoshi , Okamoto Koji
Published: March 2023

Supplementary Figure 1-7
Table. S1 from Hes1 Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma
Authors: Matsumori Tomoaki , Kodama Yuzo , Takai Atsushi , Shiokawa Masahiro , Nishikawa Yoshihiro , Matsumoto Tomonori , Takeda Haruhiko , Marui Saiko , Okada Hirokazu , Hirano Tomonori , Kuwada Takeshi , Sogabe Yuko , Kakiuchi Nobuyuki , Tomono Teruko , Mima Atsushi , Morita Toshihiro , Ueda Tatsuki , Tsuda Motoyuki , Yamauchi Yuki , Kuriyama Katsutoshi , Sakuma Yojiro , Ota Yuji , Maruno Takahisa , Uza Norimitsu , Marusawa Hiroyuki , Kageyama Ryoichiro , Chiba Tsutomu , Seno Hiroshi
Published: March 2023

Primer sequences used for real-time PCR.
Fig. S5 from Hes1 Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma
Authors: Matsumori Tomoaki , Kodama Yuzo , Takai Atsushi , Shiokawa Masahiro , Nishikawa Yoshihiro , Matsumoto Tomonori , Takeda Haruhiko , Marui Saiko , Okada Hirokazu , Hirano Tomonori , Kuwada Takeshi , Sogabe Yuko , Kakiuchi Nobuyuki , Tomono Teruko , Mima Atsushi , Morita Toshihiro , Ueda Tatsuki , Tsuda Motoyuki , Yamauchi Yuki , Kuriyama Katsutoshi , Sakuma Yojiro , Ota Yuji , Maruno Takahisa , Uza Norimitsu , Marusawa Hiroyuki , Kageyama Ryoichiro , Chiba Tsutomu , Seno Hiroshi
Published: March 2023

Histological analysis of ICC and the incidence of HCC developed in AlbcreKP; RosaNotchOE and AlbcreKP; RosaNotchOE; Hes1flox/flox mice at 8 weeks of age.
Supplementary Data from Epigenetic Inactivation of α-Internexin Accelerates Microtubule Polymerization in Colorectal Cancer
Authors: Li Yingjie , Bai Liangliang , Yu Huichuan , Cai Du , Wang Xiaolin , Huang Baoyuan , Peng Shaoyong , Huang Meijin , Cao Guangwen , Kaz Andrew M. , Grady William M. , Wang Jianping , Luo Yanxin
Published: March 2023

Supplemental Figures 1-10 and Reagent table
SupplementaryMovieLegends.pdf from The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice
Authors: Kapiainen Emmi , Kihlström Minna K. , Pietilä Riikka , Kaakinen Mika , Ronkainen Veli-Pekka , Tu Hongmin , Heikkinen Anne , Devarajan Raman , Miinalainen Ilkka , Laitakari Anna , Ansarizadeh Mohammadhassan , Zhang Qin , Wei Gong-Hong , Ruddock Lloyd , Pihlajaniemi Taina , Elamaa Harri , Eklund Lauri
Published: March 2023

Legends for Sup movies 1 and 2
Supplementary Movie 2 from The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice
Authors: Kapiainen Emmi , Kihlström Minna K. , Pietilä Riikka , Kaakinen Mika , Ronkainen Veli-Pekka , Tu Hongmin , Heikkinen Anne , Devarajan Raman , Miinalainen Ilkka , Laitakari Anna , Ansarizadeh Mohammadhassan , Zhang Qin , Wei Gong-Hong , Ruddock Lloyd , Pihlajaniemi Taina , Elamaa Harri , Eklund Lauri
Published: March 2023

Visualization of basal cell surface of ANGPT2-GFP HUVECs during cell spreading.
Supplementary Materials and Methods from The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice
Authors: Kapiainen Emmi , Kihlström Minna K. , Pietilä Riikka , Kaakinen Mika , Ronkainen Veli-Pekka , Tu Hongmin , Heikkinen Anne , Devarajan Raman , Miinalainen Ilkka , Laitakari Anna , Ansarizadeh Mohammadhassan , Zhang Qin , Wei Gong-Hong , Ruddock Lloyd , Pihlajaniemi Taina , Elamaa Harri , Eklund Lauri
Published: March 2023

Supplementary Materials and Methods
Supplementary Data from 5-Fluorouracil Enhances the Antitumor Activity of the Glutaminase Inhibitor CB-839 against PIK3CA-Mutant Colorectal Cancers
Authors: Zhao Yiqing , Feng Xiujing , Chen Yicheng , Selfridge J. Eva , Gorityala Shashank , Du Zhanwen , Wang Janet M. , Hao Yujun , Cioffi Gino , Conlon Ronald A. , Barnholtz-Sloan Jill S. , Saltzman Joel , Krishnamurthi Smitha S. , Vinayak Shaveta , Veigl Martina , Xu Yan , Bajor David L. , Markowitz Sanford D. , Meropol Neal J. , Eads Jennifer R. , Wang Zhenghe
Published: March 2023

Supplementary Figures 1-6 and Tables 1-3. Figure S1. PIK3CA mutant cells are more sensitive to a glutaminase inhibitor CB-839 than their WT counterparts. Figure S2. CB-839 enhances 5-FU tumor inhibitory effect in PIK3CA mutant CRC. Figure S3. Genes and pathways that are up-regulated in PIK3CA mutant cells after glutamine deprivation. Figure S4. Characterization of Nrf2 and its targets in CRC cells. Figure S5. CB-839 and 5-FU combinational treatment induces more DNA damage. Figure S6. Phase I clinical trial. Table S1: Patient Baseline Characteristics. Table S2. Patient information. Table S3. Treatment Related Adverse Events (all grade 3/4 AEs and grade 1/2 AEs seen in {greater than or equal to} 10% of patients).
Supplementary Figures from The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice
Authors: Kapiainen Emmi , Kihlström Minna K. , Pietilä Riikka , Kaakinen Mika , Ronkainen Veli-Pekka , Tu Hongmin , Heikkinen Anne , Devarajan Raman , Miinalainen Ilkka , Laitakari Anna , Ansarizadeh Mohammadhassan , Zhang Qin , Wei Gong-Hong , Ruddock Lloyd , Pihlajaniemi Taina , Elamaa Harri , Eklund Lauri
Published: March 2023

Supplementary Figure S1: Amino acid sequence of ANGPT2, ANGPT2443 and ANGTPT2DAP. Supplementary Figure S2: Competitive inhibition of ANGPT4-induced TIE2 phosphorylation by ANGPT2 isoforms. Supplementary Figure S3. TIE2 phosphorylation by ANGPT2 isoforms at the retracting cell edges. Supplementary Figure S4. Generation of Angpt2443 allele and the effects of Angpt2443 expression on the retina. Supplementary Figure S5. MMTV-PyMT mammary gland tumor model. Supplementary Figure S6. ANGPT2 at the Weibel-Palade bodies and the subendothelial space. Supplementary Figure S7. B16F10 melanoma lung colonization model. Supplementary Figure S8. E0771 breast cancer cell transplantation model.
Supplemental Tables from Palmitoylated Proteins on AML-Derived Extracellular Vesicles Promote Myeloid-Derived Suppressor Cell Differentiation via TLR2/Akt/mTOR Signaling
Authors: Tohumeken Sehmus , Baur Rebecca , Böttcher Martin , Stoll Andrej , Loschinski Romy , Panagiotidis Konstantinos , Braun Martina , Saul Domenica , Völkl Simon , Baur Andreas S. , Bruns Heiko , Mackensen Andreas , Jitschin Regina , Mougiakakos Dimitrios
Published: March 2023

Information regarding patient characteristics, antibodies, and primers.
Supplementary Data from Kras/ADAM17-Dependent Jag1-ICD Reverse Signaling Sustains Colorectal Cancer Progression and Chemoresistance
Authors: Pelullo Maria , Nardozza Francesca , Zema Sabrina , Quaranta Roberta , Nicoletti Carmine , Besharat Zein Mersini , Felli Maria Pia , Cerbelli Bruna , d'Amati Giulia , Palermo Rocco , Capalbo Carlo , Talora Claudio , Di Marcotullio Lucia , Giannini Giuseppe , Checquolo Saula , Screpanti Isabella , Bellavia Diana
Published: March 2023

The supplementary material file contains additional data that sustain the oncogenic role of Jag1-ICD and information about reagents utilized, as follows: - Supplementary Figure S1 recapitulates the main gene mutations in CRC cell lines . - Supplementary Figures S2 and S3 show additional data supporting the role of Jag1-ICD in sustaining EMT and chemoresistance of CRC, respectively. - Supplementary Tables add information concerning reagents utilized. Table S1 reports the oligonucleotide primers; Table S2 reports the names and the source of the antibodies.
Supplemental Figure 4 from Palmitoylated Proteins on AML-Derived Extracellular Vesicles Promote Myeloid-Derived Suppressor Cell Differentiation via TLR2/Akt/mTOR Signaling
Authors: Tohumeken Sehmus , Baur Rebecca , Böttcher Martin , Stoll Andrej , Loschinski Romy , Panagiotidis Konstantinos , Braun Martina , Saul Domenica , Völkl Simon , Baur Andreas S. , Bruns Heiko , Mackensen Andreas , Jitschin Regina , Mougiakakos Dimitrios
Published: March 2023

Changes of mitochondrial (A) membrane potential, (B) ROS production, and (C) mass in monocytes upon AML-EV uptake.
Legends of Supplementary Tables from Cyclophosphamide and Vinorelbine Activate Stem-Like CD8+ T Cells and Improve Anti-PD-1 Efficacy in Triple-Negative Breast Cancer
Authors: Falvo Paolo , Orecchioni Stefania , Hillje Roman , Raveane Alessandro , Mancuso Patrizia , Camisaschi Chiara , Luzi Lucilla , Pelicci PierGiuseppe , Bertolini Francesco
Published: March 2023

Legends of Suppl Tables
Table S1 from Bisphosphonate Use and Breast Cancer Risk among Women with Ductal Carcinoma In Situ
Authors: Li Christopher I. , Flanagan Meghan R. , Tang Mei-Tzu C. , Porter Peggy L. , Malone Kathleen E.
Published: March 2023

Additional stratified data
Supplementary Tables S2, S3, S4, S5, S6 from Systematic Analysis of Intronic miRNAs Reveals Cooperativity within the Multicomponent FTX Locus to Promote Colon Cancer Development
Authors: Kwok Zhi Hao , Zhang Bin , Chew Xiao Hong , Chan Jia Jia , Teh Velda , Yang Henry , Kappei Dennis , Tay Yvonne
Published: March 2023

Supplementary tables S2-6