bluuebunny/crossref_metadata_2025 huggingface dataset:
Writing Black Women’s Mythology: A Conversation with Deborah D.E.E.P. Mouton
Authors: Mouton Deborah D.E.E.P. , Ciftci Gulsin , Schultermandl Silvia
Published: September 2023

In commemoration of the proclamation of the end of slavery in the United States on June 19, 1865, writer, activist, and performer Deborah D.E.E.P. Mouton read from and discussed her memoir Black Chameleon at the 2023 Juneteenth Dialogue hosted by the Chair of American Studies at the University of Münster. The Juneteenth Dialogues are designed to enter into a discussion about systemic racism in the United States and to explore literary responses to the vulnerabilities of Black lives and strategies of (literary) resistance. With Deborah D.E.E.P. Mouton, the focus of conversation was on the importance of mythology for Black women in the United States, the potentials of autobiographical writing, and the importance of literature today. Mythology, in Mouton’s work, builds on what Audre Lourd called “biomythography” to combine personal experience, popular culture, history, and received narratives that are part of ancient storytelling traditions. In Mouton’s hands, this becomes a technique for getting closer to some of the complex truths of a past grounded in enslavement. Mouton’s reading from Black Chameleon and the panel discussion that followed are the basis of this interview. It has been edited for clarity. We want to thank the audience of the 2023 Juneteenth Dialogues as well as Dr. Ortwin Lämke and Frederik Köpke from the Studiobühne for providing the space for this event.
РОЗДІЛ 3. АКТУАЛЬНІ ПИТАННЯ ЕЛЕКТРОННОГО УРЯДУВАННЯ В СУЧАСНОМУ ПРАВОВОМУ ПРОСТОРІ
Authors: Гаран Ольга Володимирівна
Published: September 2023

Досліджено питання електронного урядування в сучасних умовах і акцентована увага на розумінні цього правового явища та формах (рівнях) його реалізації. Проведено аналіз основних концептуальних підходів до розуміння сутності е-урядування і з’ясовано, що найбільш вживаними є шість основних наукових підходів. Представлено авторське визначення електронного урядування. Окреслено чотири сфери прояву електронного урядування: Електронні послуги (e-services); Електронне управління (e-management); Електронна демократія (e-democracy); Електронна комерція (e-commerce).
Окрема увага була приділена формам (рівням взаємодії) е – урядування: G2G – « Уряд – уряду; G2B – «Уряд – бізнесу»; G2C – «Уряд – громадянам»; G2Lg – «Уряд – органи місцевого самоврядування»; G2N – «Уряд – неурядовим організаціям»; G2E – «Уряд державним службовцям»; G2I – «Уряд – міжнародні організації».
Результатами дослідження стало визначення поняття е-урядування та окреслення основних векторів трансформації рівнів реалізації електронного урядування в сучасних умовах і зміна їх сутності під впливом викликів сьогодення, а також надані пропозиції щодо удосконалення розуміння моделей е-урядування із урахуванням інтеграції України в європейський правовий простір.
РОЗДІЛ 6. ЕФЕКТИВНІСТЬ ВИКОРИСТАННЯ ПУБЛІЧНИХ КОШТІВ ЯК АКСІОЛОГІЧНА ОСНОВА ДЕРЖАВНОЇ РЕГУЛЯТОРНОЇ ПОЛІТИКИ
Authors: Петруненко Ярослав Вікторович
Published: September 2023

У роботі висвітлюються окремі питання ефективного використання публічних коштів як аксіологічної основи державної регуляторної політики у сфері господарської діяльності. З’ясовано взаємозв’язок між механізмом використання публічних коштів та формуванням державної політики у сфері регулювання економічних відносин. Автором визначається поняття та критерії ефективності використання публічних коштів у процесі реалізації державної регуляторної політики. Досліджено правові засади забезпечення ефективного використання публічних коштів, визначаються шляхи удосконалення відповідного законодавства. Охарактеризовано види юридичної відповідальності за порушення законодавства у сфері використання публічних коштів. Особлива увага приділяється аналізу досвіду деяких зарубіжних країн у сфері забезпечення ефективного використання публічних коштів у процесі реалізації державної регуляторної політики. На підставі проведеного дослідження автором сформульовано критерії ефективності використання публічних коштів у процесі державного регулювання економічних відносин.
РОЗДІЛ 8. ОБМЕЖЕНІ РЕЧОВІ ПРАВА У ПРАВОПОРЯДКАХ НІМЕЧЧИНИ, ФРАНЦІЇ ТА УКРАЇНИ: ТРАДИЦІЇ ТА ПЕРСПЕКТИВИ РОЗВИТКУ
Authors: Федорко Марина Сергіївна
Published: September 2023

Процеси глобалізації права, які відбуваються останнім часом, зумовлюють інтенсивну модернізацію речового права, що має наслідком позначення певних тенденцій його розвитку, які простежуються в більшості правопорядків. Не є винятком й Україна. Так, у Концепції оновлення Цивільного кодексу України, яка була підготовлена членами Робочої групи, створеної на виконання Постанови Кабінету Міністрів України «Про утворення робочої групи щодо рекодифікації (оновлення) цивільного законодавства України» від 17 липня 2019 р. № 650 запропоновані структурні та змістовні зміни системи речових прав. Відправною точкою в реформуванні вітчизняної правової бази, її вдосконаленні та приведенні у відповідність з об’єктивними потребами суспільства та обороту мають стати законодавчі та доктринальні положення та правозастосовна практика інших правових систем. Оскільки в основу Концепції оновлення Цивільного кодексу України покладено сучасний досвід рекодифікації цивільних кодексів Франції та Німеччини, автор на підставі аналізу положень законодавства, доктрини та судової практики зазначених країн досліджує зміст окремих обмежених речових прав.
Сонце в ХХI столітті: 24 сонячний цикл – початок 2-ї епохи зниженої сонячної активності
Authors: Ішков В. М.
Published: September 2023

Ми розлучилися з читачами календаря, коли 24-й цикл сонячної активності (СА) тільки вступив у завершальний період свого розвитку – останні 2 роки фази мінімуму, а зустрічаємося знову, коли поточним циклом вже майже два роки став 25-й.
Сонячні та місячні затемнення
Authors: Базей О. А.
Published: September 2023

У 2022 році буде 4 затемнення – 2 сонячні та 2 місячні. Три з них будуть видимі з території України. Перше затемнення буде сонячним. Воно відбудеться 30 квітня. Це часткове затемнення, найбільша фаза якого 0.64 настане о 23 годині 41 хвилині за київським часом неподалік узбережжя Антарктиди. Затемнення видно у південно-східній частині Тихого океану, в Чилі та в західній частині Аргентини на заході Сонця.
EXPERIÊNCIA DE MOÇAMBIQUE NA GESTÃO DE CALAMIDADES E RECUPERAÇÃO PÓS-DESASTRES SOCIOAMBIENTAIS (2019-2023)
Authors: Ndapassoa Anastásio Miguel
Published: September 2023

Depois da ocorrência dos ciclones Idai e Kenneth, e apesar do nível de pobreza em que Moçambique se encontra, tem estado a recuperar-se a um ritmo aceitável, com ajuda de doadores e parceiros internacionais. Assim, Moçambique constitui um exemplo em matéria de recuperação pós-desastres socioambientais ou está longe disso? No primeiro caso, a que se deveria esse contraste? Em contexto de ocorrência de eventos climáticos extremos, uma sólida gestão financeira é determinante para uma boa prevenção, uma boa mitigação e uma rápida recuperação. Ciente disso, o país tem vindo a organizar-se em termos de criação de instituições vocacionadas, gestão de emergências e adoção de legislação correspondente. Contudo, o país vem falhando na componente de gestão financeira. O objetivo deste artigo é aferir até que ponto a experiência de Moçambique pode servir de exemplo na região e no mundo, tendo em conta que existem outros países que também são vítimas de eventos climáticos extremos. Quanto aos objetivos específicos, pretende-se analisar e discutir de que modo a gestão e a recuperação pós-desastres socioambientais são realizadas pelas autoridades moçambicanas e se estão alinhadas às práticas e aos padrões internacionais, de modo que se possa comparar com outros países, nas mesmas circunstâncias. A metodologia de pesquisa utilizada foi qualitativa, sendo exploratória quanto aos objetivos. Quanto aos procedimentos técnicos, lançou-se mão de pesquisa bibliográfica e documental, desenvolvida com base em livros, artigos científicos, relatórios, estudos, textos e legislação. O método de procedimento da pesquisa foi o comparativo. Concluiu-se que Moçambique pode até ter experiências para partilhar, mas ainda deve trilhar um longo caminho para se tornar referência.
A new marker in post-pancreatectomy fistulas; hypophosphatemia
Authors: ÇETİNDAĞ Özhan , ÜNAL Ali Ekrem
Published: September 2023

Aim: Postoperative hypophosphatemia is associated with morbidity after many gastrointestinal surgeries. In this study,

we aimed to investigate the relationship between hypophosphatemia and POPF, which is one of the morbidities after pancreatectomy.

Material and Methods: All adult patients who underwent pancreatectomy in our surgical oncology clinic from 2010 to 2020 were included in the patient data recording system to the Faculty of Medicine of Ankara University, Surgical Oncology clinic. Exclusions were made for those under 18, without postoperative Jackson-Pratt (jp) amylase levels, and with previous pancreatic surgery.

Results: Examination of a total of 185 patients showed that fistula occurred in 20% of cases. Statistical analysis revealed that postoperative 2nd and 3rd-day phosphorus levels are markers for pancreatic leak.

Conclusion: Decreased phosphate values after pancreatic surgery may be an indicator for pancreatic fistula, especially significant on the 2nd and 3rd postoperative days
Baş boyun kanserli hastalarda tek gen polimorfizmi ile sisplatin ve 5-FU tedavisine yanıt arasındaki ilişki
Authors: DEMİRAY Aydın , KARAGÜR Ege Rıza , AKÇA Hakan , TOKGÜN Onur , DEMİRAY Atike Gökçen , BİR Ferda
Published: September 2023

Amaç: Baş ve boyun kanserleri dünya çapında en sık görülen altıncı kanser türüdür. Baş ve boyun kanserlerinin tedavi süreci kemoterapi veya kemoradyoterapi olarak sınıflandırılır. Bu çalışmada ERCC1, XRCC1 ve MTHFR genlerinin tedavi ile yanıt ilişkisi araştırıldı.

Gereç ve Yöntemler: Çalışmada tek nükleotid polimorfizmini araştırmak amacıyla hastalardan 5 ml kan alınarak DNA izole edildi ve pirosequencing yöntemiyle araştırıldı.

Bulgular: Hastalar RECIST kriterlerine göre değerlendirildi; tedaviden önce (4 hafta) ve her üç siklustan sonra baş ve boyun bilgisayarlı tomografi taramaları yapıldı. Genel yanıt oranı (RR) 10 (%25) PD, 7 (%17,5) SD, 9 (%22,5) PR ve 14 (%35) CR idi. En az bir polimorfik varyantı olan hastaların dördünde PD, 3'ünde SD, 3'ünde PR ve 1'inde CR vardı.

Sonuçlar: Bu çalışmada bir grup baş boyun karsinomu hastasının klinik davranışı, üç tek nükleotid polimorfizmi ile ilişki açısından retrospektif olarak değerlendirildi. Bunlar arasında ERCC1 geninde C8092A, XRCC1 geninde G28152A ve MTHFR geninde C677T ve A1298C yer alıyordu.
Potentials of Predators of Weaver Ants Towards Caterpillar in Palm Plantation with The Test Preferences Method
Authors: Falahudin Irham , Septriani Shafira
Published: September 2023

The problem that arises in palm oil plantation operation on a huge scale is the appearance of caterpillar pest that attacks palm oil plants. There are several important pests that attack palm oil plants such as caterpillars which are the sort of Setora nitens. The appearance of the past becomes an important concern for the world’s plantation. How to eradicate the pest naturally is the performed effort. This effort can be done by using weaver ant. Weaver has the potential as the natural enemy of palm oil because they can be nesting in arboreal areas. So, this research object will focus on observing the weaver ant (Ocoephylla smaragdina) predator ability by using the forage preference test method toward several types of dominant pests in palm oil plants, especially caterpillars. Preference for choice and no-choice tests. The material used is an oil palm plantation with four species of caterpillar as the main pest on a palm plantation. The tool used in the test box amount to four in which each of the six different types of caterpillars are inserted. This research is conducted on a laboratory scale by using a complete random program experiment (CRP) and was conducted in April 2016 at Biology Laboratory UIN Raden Fatah Palembang. The research results show that the weaver ant (O. smaragdina) can prey on the S. nitens caterpillar the similarity test average is 87,50% by using a nonchoice technique. The choice methods O. smaragdina can be prey 41,67% S. nitens. In the similarity test average choice techniques are different (83,33%).
THE EFFECT OF INTERNAL AUDIT SYSTEM AND IMPLEMENTATION OF GOOD CORPORATE GOVERNANCE ON FRAUD
Authors: Triningsih Cindy , Rokan Mustapa Khamal , Ilhamy Nasution Muhammad Lathief
Published: September 2023

The purpose of this study was to determine the effect of the internal audit system and the application of good corporate governance on fraud at Indonesian Islamic banks (BSI). This study collected data and information by sending questionnaires to 97 people who work at Bank Syariah Indonesia (BSI) in Rantau Parapet, North Sumatra. The analysis technique uses multiple regression by testing the hypothesis t test and F test. The results show that the significance value of the internal audit system variable is 0.035 <0.05, which means that the internal audit system variable has a significant influence on fraud, the significance value of the good implementation variable corporate governance of 0.035 <0.05, which means that the variable implementation of good corporate governance has a significant influence on fraud (Fraud). Then simultaneous testing shows the result that the significant value of F is 0.000 <0.05 which means that simultaneously the internal audit system and good corporate governance have an effect on fraud. The conclusion is that both partially and simultaneously the internal audit system variables and good corporate governance have an effect on fraud.
Profil Literasi Sains Peserta Didik SMK pada Penerapan Pembelajaran Projek Electroplating Berbasis Green Chemistry
Authors: Purwanti Purwanti , Hernani Hernani , Khoerunnisa Fitri
Published: September 2023

Scientific literacy is one of the main keys for education personnel in facing the challenges of the 21st century which continues to experience global changes. Project learning is carried out to increase scientific literacy and achieve sustainable development. This study aims to describe the scientific literacy profile of vocational students in the application of green chemistry-based electroplating learning projects. The principles of green chemistry raised in the electroplating project are the use of safe chemicals, the use of green solvents, and waste prevention. The research method used was a descriptive analysis. The research subjects were 27 students from the Industrial Mechanics Engineering program in the Department of Technology and Engineering at a Vocational School in the city of Cimahi for the 2022-2023 Academic Year, selected using the convenience sampling technique. Data collection techniques were carried out using 20 scientific literacy test instrument questions with four answer choices that have been validated and tested for reliability. Data analysis was carried out by paired t-test on pretest and posttest values using the Microsoft Excel program. The scientific literacy profile of SMK students in the domain of science knowledge is categorized as low with a percentage of 48%, the scientific competence domain is categorized as moderate with a presentation of 66%, and the attitude domain is categorized as moderate with a percentage of 63%.
Desain dan Uji Validitas e-Modul Perkuliahan Kimia Fisika Berbasis Problem Based Learning
Authors: Dwi Cahyani Mutiara , Gusman Tania Avianda
Published: September 2023

The rapid development of technology requires education to participate in the use of technology as an innovation in learning. The purpose of this research is to develop and test a surface tension e-module based on Problem Based Learning in the Chemistry Physics course. The research method used in this study is Research and Design using the ADDIE development model which is limited to the analysis, design and development stages. The instrument used to determine the feasibility of the e-module is a questionnaire to test the validity of media experts and material experts. Respondents for testing the validity of media experts and material experts were educators in university and high schools. The feasibility level of the e-module is based on the validation of material experts by 80% which states that the quality of the material in the e-module is feasible from the material aspect and is based on problem based learning, the validation of media experts is 86.7% which states that the quality of the display on the e-module is very decent from the aspect of the media. This shows that the surface tension e-module based on problem based learning is feasible to use and implement in the learning process for university and high school levels.
Emergency endovascular treatment of cardioembolic stroke in the early post-infarction period with subsequent direct myocardial revascularization
Authors: Arutyunyan A. G. , Kokov L. S. , Mazanov M. Kh. , Bikbova N. M. , Ramazanov G. R. , Anisimov А. V.
Published: September 2023

Introduction. Ischemic stroke (IS) remains one of the significant problems of modern medicine to this day. Cardioembolic stroke (CEI) accounts for 20 % of all cases of IS and is characterized by acuteness, severity of the disease and high mortality.

Aim of study. An observation is presented in patient Sh., 51 years old, who was urgently transferred from another medical institution on the 3rd day after the development of acute recurrent anterior myocardial infarction with ST segment elevation complicated by early post-infarction angina pectoris. During the additional examination, in addition to severe multifocal atherosclerosis and multivessel coronary artery disease, a floating thrombus in the cavity of the left ventricle was detected. At the stage of preparing the patient for coronary artery bypass grafting, the patient developed stroke. Thrombextraction from the basilar artery (BA) was performed urgently. As a result, a complete regression of neurological symptoms was achieved. This made it possible to continue the preparation and successfully perform coronary artery bypass grafting. The patient was discharged on the 10th day after the operation, the entire hospitalization period was 28 bed-days.

Discussion. In the presented case, a patient with a clinic of unstable angina pectoris, severe multifocal atherosclerosis, and multivessel coronary artery disease was in a specialized multidisciplinary hospital at the time of the development of stroke. The well-coordinated work of the multidisciplinary team, the possibility of performing thromboaspiration in the shortest possible time allowed not only to save the patient's life and achieve complete regression of neurological symptoms, but also to improve the quality of life through surgical treatment of coronary heart disease.
The relationship of systemic inflammatory response with structural and functional changes in the myocardium in patients with pulmonary tuberculosis
Authors: Kolchin D. V. , Ruzov V. I. , Savonenkova L. N. , Razin V. A.
Published: September 2023

Abstract. Taking into account the conflicting data on the effect of the systemic inflammatory response on the structural and functional changes in the myocardium in clinical forms of tuberculosis, we conducted an echocardiographic study and an assessment of pro- and anti-inflammatory cytokines in the blood serum.

The purpose: to study the relationship of structural and functional changes in the myocardium with markers of systemic inflammation IL-6, IL-10, VEGF-A in patients with various forms of pulmonary tuberculosis.

Materials and methods. The study included 77 patients with a confirmed diagnosis of pulmonary tuberculosis, who are on inpatient treatment in a tuberculosis dispensary. During the study, patients were randomized into 3 groups, cavernous form of pulmonary tuberculosis, (n = 15). The mean age of the patients was 44.2 ± 5.3 years and had no statistically significant differences between the groups. The control group consisted of 10 healthy individuals. The mean age of the control group was 42.4 ± 2.3 years. The concentration of IL-6, IL-10 and VEGF-A in blood serum was assessed by ELISA and В-mode echocardiography.

The results obtained. The severity of systemic inflammation was associated with the clinical form of pulmonary tuberculosis: the maximum value of IL-6 was observed in the infiltrative form, and the minimum, but significantly higher value compared to the control group, in the fibrous-cavernous form of pulmonary tuberculosis (25, 7 ± 16.5 vs 10.3 ± 4.24). High levels of interleukin IL-6 were accompanied by higher levels of VEGF in blood serum, regardless of the form of pulmonary tuberculosis, while the highest concentration of both was observed in patients with infiltrative form of tuberculosis . A significant increase in the structural and functional values of the myocardium of the right and left parts of the heart was established both in relation to the control group and in comparison with the group of patients with an infiltrative form of pulmonary tuberculosis, despite lower levels of VEGF-A (391.43 ± 241.0 vs 274.50 ± 158.30).

Conclusions. Pulmonary tuberculosis is accompanied by varying severity of systemic inflammation associated with the clinical form of the disease. Structural and functional changes in the myocardium of the right and left parts of the heart in pulmonary tuberculosis are associated with the clinical form of pulmonary tuberculosis. The most pronounced changes are observed in the fibrous-cavernous form, the minimum - in the infiltrative form. There is no direct relationship between the severity of the systemic inflammatory response and structural and functional changes in the heart.
Pathogenetic therapy of multiple sclerosis
Authors: Komissarova N. V. , Urban M. A. , Gaysina D. M. , Gimazdinova A. R. , Perevozchikova Ya. M.
Published: September 2023

Relevance. Multiple sclerosis is accompanied by rapid progression of the disease, the development of early disability and a violation of the patient's quality of life. In recent years, advances in understanding the etiology and pathogenesis of this disease have led to the expansion of therapeutic approaches, it has become possible to influence the course of the disease. Objective - to study the effectiveness of the use of drugs that change the course of multiple sclerosis in patients registered at the center of multiple sclerosis of the Udmurt Republic.

Materials and methods. The statistical analysis was performed on 45 patients of the neurological department of the "First Republican Clinical Hospital" of the Ministry of Health of the Udmurt Republic, diagnosed with multiple sclerosis, using immunomodulatory or immunosuppressive therapy.

Results. At the beginning of the study, the group of patients using immunomodulatory therapy included 31 patients (68.89 %), the group of immunosuppressors -14 patients (31.11 %). The average time from the onset of the disease to the start of therapy was 1.64 ± 5.71 months. 42 patients (93.33 %) out of 45 included in the study started therapy with an immunomodulator. The average time from the start of therapy to inclusion in the study was 113.00 ± 47.52 months in the immunomodulatory therapy group. 11 patients (78.57 %) out of 14 taking immunosuppressive therapy at the start of the study switched to it after previous immunomodulatory therapy. 3 patients (6.67 %) out of 45 included in the study started treatment with immunosuppressive therapy. In the immunosuppressive therapy group, the duration of treatment was 62.57 ± 74.52 months. Progression of the disease from the moment of initiation of therapy to inclusion in the study was observed in 19 patients - 42.22 %. An increase in the EDSS index was recorded by an average of 1.82 ± 0.31 points. Improvement of clinical condition was observed in 6 patients - 13.33 %. A decrease in the EDSS index was recorded by an average of 0.91 ± 0.22 points. The difference in the EDSS index in the groups of immunomodulators and immunosuppressors is insignificant. There was no dependence of the patient's clinical condition on the number and activity of foci of demyelination.

Conclusions. The objective clinical condition of the patient has no significant difference in the groups of immunomodulatory and immunosuppressive therapy, which suggests that the correct selection of a particular drug by the attending physician and its constant use by the patient is important in order to reduce the risks of complications, slow down the progression of the disease and preserve the quality of life of the patient.
Mathematical modeling of ethanol distribution in body fluids
Authors: Nedugov G. V.
Published: September 2023

The aim of the study is to build a kinetic model of ethanol distribution in biological body fluids, as well as its implementation in the format of computer programs. Analytical mathematical modeling of ethanol kinetics in body fluids after single and multiple oral alcohol intake was performed. An equation for the distribution of ethanol in internal media and other body fluids has been developed based on a kinetic model of zero-order elimination with absorption and irrevocable absorption deficiency, as well as achieving an equilibrium state with first-order blood plasma. On the basis of this kinetic model, computational algorithms are constructed for estimating the concentration of ethanol in body fluids at a given time, the peak concentration of ethanol and the time of its achievement, the time of complete removal of ethanol, the beginning and end of the false elimination period. Solutions to the problem of determining the amount of ethanol taken by its concentration in the biological fluid and the level of etholemia at this point in time with the possibility of calculating their maximum absolute errors are obtained. The constructed kinetic model is generalized to any number of ethanol receptions separated by time intervals of any duration. The developed computational algorithms are implemented in the format of the computer programs 'Alcohol Calculator V 7.0" and "Alcohol Calculator V 6.0", which are recommended for use in the forensic medical expert assessment of acute alcohol intoxication.
Molecular mechanisms for targeted treatments in fragile X syndrome
Authors: Miranda Isabel , Hagerman Randi
Published: September 2023

Fragile X syndrome (FXS) is caused by a full mutation (> 200 repeats) in the 5’untranslated region of the Fragile X Messenger Ribonucleoprotein 1 gene (FMR1 gene), which leads to methylation and silencing of expression, generating the total or partial absence of its product, FMR1 protein (FMRP). When the repetitions are between 55 and 200 cytosine-guanine-guanine (CGG) repeats, it is called a premutation, which is related to a wide spectrum of conditions such as Fragile X-associated tremor ataxia syndrome (FXTAS), fragile X-associated primary ovarian insufficiency (FXPOI), and fragile X-associated neuropsychiatric disorders (FXAND). High levels of FMR1 mRNA are implicated in premutation pathophysiology, which differs from the deficiency or absence of FMRP in FXS. In recent years, numerous attempts have been made to find treatments that can counteract the effects of the absence of FMRP and improve symptoms associated with the condition such as intellectual disability, anxiety, autism, stereotypies, language delay, and aggressive behavior. Here, we review current treatments in addition to targeted treatments that can reverse some of the neurobiological abnormalities in those with FXS. We also review molecular interventions that will hopefully lead to a promising future for those affected by FXS and their families.
Penggunaan Kompos Cair Bonggol Pisang sebagai Sumber Hara pada Hidroponik Bawang Merah
Authors: Faozi Khavid , Purwantono Anung Slamet Dwi , Supartoto Supartoto , Ma'ruf Nuriman
Published: September 2023

Penelitian ini bertujuan untuk mengetahui penggunaan kompos cair berbahan dasar bonggol pisang untuk mengurangi penggunaan nutrisi AB Mix pada hidroponik bawang merah. Penelitian dilaksanakan pada bulan Juli sampai September 2021 di Desa Rempoah, Kecamatan Baturraden, Kabupaten Banyumas, Jawa Tengah, Indonesia. Jenis perlakuan yang digunakan adalah komposisi dosis nutrisi AB Mix dan kompos cair bonggol pisang yang terdiri dari 6 jenis yaitu P1 = Kontrol (100 % AB Mix), P2 = (80 % AB Mix, 20 % kompos cair), P3 = (60 % AB Mix, 40 % kompos cair), P4= (40 % AB Mix, 60 % kompos cair), P5= (20 % AB Mix, 80 % kompos cair), P6= (100 % kompos cair). Hasil penelitian menunjukkan bahwa penggunaan kompos cair berbahan bonggol pisang mampu menurunkan penggunaan AB Mix sebesar 40%, dengan menghasilkan rata-rata total 8,13 umbi, rata-rata berat umbi segar 40,35 g, dan rata-rata hasil umbi per tanaman 37,40 g.
Long COVID, POTS, CFS and MTHFR: Linked by Biochemistry and Nutrition
Authors: Chambers Patrick
Published: September 2023

These three syndromes - long covid (LC), postural orthostatic tachycardia syndrome (POTS), and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) - have many symptoms in common. The common denominator remains elusive. The blood brain barrier (BBB) has been a barrier not only to microbes and toxins but also to understanding pathogenetic links. There are several areas within the brain that have no BBB. These are known as circumventricular organs (CVOs) and their location relative to CNS nuclei that direct autonomic and neuroendocrine functions is provocative in the quest for pathogenesis. In addition the majority afflicted with LC and ME/CFS appear to be those with two MTHFR polymorphisms, present in over 50% of Americans. These polymorphisms elevate homocysteine. When homocysteine is combined with CVOs, the fog of POTS and its paradox are lifted. POTS may represent the intersection of LC and ME/CFS in those with the MTHFR gene (hypermethylation or 677TT). The gut microbiomes of LC and ME/CFS, deficient in butyrates, GABA, and diversity, are then linked with MTHFR genotype 677TT. Reactivation of neurotropic EBV and VZV, due to loss of surveillance by CD4+/CD8+ T cells, is seen as secondary. The oxidative stress generated by homocysteine, loss of glutathione, low fiber diet, and persistent chronic inflammation exhaust available mitochondria and, assisted by BKN and estrogen, exacerbate all the elements of these post viral fatigue syndromes.
Research on the Application and Performance Optimization of GPU Parallel Computing in Concrete Temperature Control Simulation
Authors: Zheng Xuerui , Qiang Sheng , Jin Jiping , Wang Yajun , Yuan Min
Published: September 2023

With the development of engineering technology, engineering has higher requirements for the accuracy and the scale of simulation calculation. The computational efficiency of traditional se-rial program can not meet the requirements of engineering。Therefore, reducing the calcula-tion time of temperature control simulation program has important engineering significance for real-time simulation of temperature field and stress field, and then adopting more reasona-ble temperature control and crack prevention measures. GPU parallel computing is introduced into the temperature control simulation program of massive concrete to solve this problem and the optimization is carried out. Considering factors such as GPU clock rate, number of cores, parallel overhead and Parallel Region, The improved GPU parallel algorithm analysis indicator formula is proposed. It makes up for the shortcomings of traditional formula that focus only on time. According to this formula, when there are enough threads, the parallel effect is limited by the size of the parallel domain, and when the parallel domain is large enough, the efficiency is limited by the parallel overhead and the clock rate. This paper studies the optimal Kernel execu-tion configuration. Shared Memory is utilized to improve memory access efficiency by 155%. After solving the problem of bank conflicts, an accelerate rate of 437.5x was realized in the sub-routine of the matrix transpose of the solver. The asynchronous parallel of data access and logi-cal operation is realized on GPU by using CUDA Stream , which can overlap part of the data access time. On the basis of GPU parallelism, asynchronous parallelism can double the compu-ting efficiency. Compared with the serial program, the accelerate rate of inner product matrix multiplication of the GPU asynchronous parallel program is 61.42x. This study further proposed a theoretical formula of data access overlap rate to guide the selection of the number of CUDA streams to achieve the optimal computing conditions. The GPU parallel program compiled and optimized by CUDA Fortran platform can effectively improve the computational efficiency of the simulation program for concrete temperature control, and better serve for engineering computing.
Effect of Laterally Moving Tactile Stimuli to Sole on Anticipatory Postural Adjustment of Gait Initiation
Authors: Kunimura Hiroshi , Oda Hitoshi , Kawasaki Taku , Tsujinaka Ryo , Hamada Naoki , Fukuda Shiho , Matsuoka Masakazu , Hiraoka Koichi
Published: September 2023

The purpose of the present study was to investigate the effect of the laterally moving tactile stimuli to the sole on the anticipatory postural adjustment (APA) of the gait initiation. Thirteen healthy males participated in this study. A sound cue was provided at the beginning of each trial. The moving tactile stimuli were delivered to the sole after the start cue. The loci of the tactile stimuli moved from the left to right most side of the sole, and then moved from the right to left most side of that in a stimuli cycle. The duration of one stimuli cycle was 960 ms, and this cycle repeated 16 times in a trial. The participants made three steps forward from quiet stance at the participants' preferred time after the start cue. The APA did not onset at the specific direction or phase of the moving tactile stimuli, indicating that they did not use the stimuli as a trigger for initiating the gait. The moving tactile stimuli decreased the amplitude and increased the duration of the APA. The moving tactile stimuli increased the time between the APA onset and toe-off of the initial support leg, indicating that they moved slower when initiating gait during the moving tactile stimuli. Those findings are explained by the view that suppression of the APA induced by the moving tactile stimuli to the sole is caused by the decrease in the velocity of the gait initiation, and the slower velocity of the gait initiation is caused by masking tactile sensation of the sole.
Effects of Aluminium Oxide Content on the Regenerated Magnesia-Calcium Bricks for Cement Rotary Kiln
Authors: Qiu Gui–bo , Hao Yi–dang , Hou Jia , Wang Hui–gang , Zhang Xuan–hao , Peng Ben , Zhang Mei
Published: September 2023

The regenerated magnesia-calcium brick samples that had added 0, 1.5, 3.0 wt.% aluminium oxide (Al2O3) were prepared by using spent magnesia-calcium bricks, fused magnesia and Al2O3 powder additive as the main raw materials. The phases, microstructures, room temperature and hot flexural strength, resistance to cement clinker corrosion and strength of coating adherence were investigated respectively. It indicated that the addition of Al2O3 increased mainly resulting in the content of tetracalcium aluminoferrite (C4AF) and tricalcium aluminate (C3A) increased in the regenerate samples. The bulk density, the room temperature flexural strength and the strength of coating adherence all increased, while the hot flexural strength and corrosion resistance both deteriorated along with the increase of Al2O3 addition. It was because that on the one hand the low melting point phases of C4AF and C3A improved the sinterability of the regenerated samples during the burning stage, on the other hand they melted or existed in liquid phase during the experimental temperature (1573 K and 1823 K) which degraded hot flexural strength and corrosion resistance, and enhanced the strength of coating adherence as the wettability of the liquid phase. The content of Al2O3 in the regenerated magnesia-calcium brick should not be higher than 1.1 wt.%, considering its room and high-temperature performances for cement rotary kiln.
A Methodological Approach for Digital Twin Implementation in Waste Management: Improvement of Production and Service Systems
Authors: Vargas Barbosa Jhonathan Mauricio , Castrillón Gómez Omar Danilo , Giraldo García Jaime Alberto
Published: September 2023

The escalating environmental challenges that stem from urban residential waste in densely populated areas have become increasingly prominent in recent times. As a result, the waste management sector has experienced significant growth nationwide. However, due to the predominantly manual nature of these processes, their effectiveness falls short of meeting the current demand. Addressing these issues requires process enhancement. In this context, Industry 4.0, particularly the concept of Digital Twins, emerges as a potential avenue for refining processes. To tackle both current and future industry challenges, it is imperative to create a comprehensive methodology capable of generating effective solutions within the waste management sector. This paper provides an explanation of digital twins, outlines the methodological framework comprising an architectural structure and layered model, and details a series of sequential methodical stages for implementing digital twins based on the specific scope determined by the end-user. A noteworthy aspect is the transformative potential of digital twins in enhancing efficiency and precision within waste management practices. By providing a virtual real-time representation of the waste management system, digital twins empower simulations and experimentation to fine-tune processes. Furthermore, they facilitate informed decision-making by offering a detailed visualization of the complete system, simplifying the identification of challenges and opportunities for improvement. that this article derives from the presentation titled "Digital Twin application methodology for the improvement of production and service systems. Application to waste management processes" at the "Sustainable Smart Cities and Territories International Conference" held in the city of Manizales, Colombia, from 21st to 23rd June 2023.
Experimental and Numerical investigation on Pile Foundation Underpinning Structure System in Urban Overpass
Authors: Yan Lei , Gou Xiaoying , Guo Zhengchao , Zhang Xin , Jiang Yu , Ran Xingwen , Chen Guanwen , Yue Kefeng
Published: September 2023

In view of the complexity of the pile foundation underpinning structure system and the stringent requirements of the construction process, this paper briefly describes the necessity of introducing epoxy resin reinforcing adhesive of planting rebar in the design of pile foundation underpinning beam structure to im-prove the mechanical properties of the underpinning beam new and old concrete joint surfaces and proposes a new type of pile foundation underpinning beam system construction method by “chiseling + prestressed reinforcement + epoxy resin reinforcing adhesive”. This paper uses an actual pile foundation underpinning project of an urban overpass as a prototype, designs and creates a model structure with a similarity ratio of 1/6, and performs repeated pro-gressive static loading tests to study the load carrying capacity, displacement change, and other properties of the underpinning structure, as well as analyses and distorts the overall working performance and failure mode of them. On this basis, the prototype structure's finite element analysis model was built, and the finite element analysis results were compared with the test results to get the mechanical properties and deformation characters of the actual pile foundation under-pinning structure system corresponding to the actual underpinning beam load. This paper's study can lay the theoretical and experimental foundation for the smooth development of similar projects.
Develop of Methods for an Overhead Cable Asset Soundness Evaluation Considering Economic Feasibility
Authors: Lee Hyeseon , Lee Byungsung , Han Gyurim , Kim Yuri , Kim Yongha
Published: September 2023

To supply stable and high-quality power according to the advancement of industrial growth, electric power companies have performed maintenance of power facilities using various meth-ods. In the case of domestic power distribution facilities, there are limitations in performing di-agnostic management on all facilities owing to the large number of facilities; therefore, old fa-cilities are managed by the health index assessment method. The health index assessment com-prises only facility operation data and external environmental data and is managed only for four types of distribution facilities, including overhead/underground transformers and switchgear. In the case of extra high–voltage overhead wires, there is no standard for old replacement, despite the large number of wires, such as transformers and switchgear, and the large ripple effect of power failure in the event of a power outage. Therefore, in this paper, a health index assessment methodology for extra-high voltage overhead cables was developed. In this paper, we devel-oped an economic health index assessment methodology that additionally considers risk cost, which is different from the existing health index assessment method that uses only operational data and external environmental data to determine facility performance evaluation and aging replacement criteria. Using the health index assessment methodology developed in this paper, it is possible to expect a reduction in facility operating costs and investment costs from the per-spective of electric power companies through the replacement of old extra-high voltage over-head cables. In addition, from the perspective of consumers, it is expected to increase power re-liability and reduce the ripple effect of failure by preferentially replacing equipment with a high probability of failure.
Can Chitosan Applications in Pre- and Post-Harvest affect the Quality and Antioxidant Contents of Red Raspberries?
Authors: Lo Piccolo Ermes , Quattrocelli Piera , Becagli Michelangelo , Cardelli Roberto , El Horri Hafsa , Guidi Lucia , Landi Marco , Pecchia Susanna
Published: September 2023

Red raspberry fruit production is increasing worldwide due to the growing consumer interest in foods with high antioxidant properties. However, raspberries are very perishable fruit with a short shelf life. Chitosan applications have shown promising results in promoting the storage of different berry fruit. This work aimed at analysing the effects of chitosan applied in pre- and/or post-harvest on the quality and antioxidant properties of raspberry fruit during the cold storage and room temperature conditions (i.e., 6 d at 4 °C and 3 d at 20 °C, respectively). Pre-harvest chi-tosan applications reduced fruit weight loss during cold storage and room temperature condi-tions but also reduced fruit decay at room temperature conditions. Furthermore, pre-harvest treatments with chitosan increased the total phenol and anthocyanin contents and promoted the highest total antioxidant activity with respect to other treatments. Of note, after the cold storage, post-harvest chitosan application drastically reduced the development of fungi that cause fruit decay, thus minimizing the potential risk of mycotoxin production. Overall, this study demon-strates that applications of chitosan in pre-harvest are sufficient to ensure the goal of maintaining and/or increasing the quality and antioxidant properties of fruit during cold storage and room temperature conditions.
A Cancer-Specific Monoclonal Antibody against HER2 for Breast Cancers
Authors: Suzuki Hiroyuki , Kaneko Mika K , Kato Yukinari
Published: September 2023

Overexpression of human epidermal growth factor receptor 2 (HER2) in breast and gastric cancers is an important target for monoclonal antibody (mAb) therapy such as trastuzumab. All therapeutic mAbs, including anti-HER2 mAbs, exhibit adverse effects probably due to the recognition of antigens expressed in normal cells. Therefore, tumor-selective or specific mAbs have been desired to reduce adverse effects. In this study, we provide a strategy for the selection of cancer-specific mAb against HER2. We screened more than 200 of anti-HER2 mAbs obtained by our laboratory and established a novel cancer-specific anti-HER2 antibody, H2Mab-250 (IgG1, kappa). H2Mab-250 reacted with HER2-positive breast cancer BT-474 and SK-BR-3 cells. Importantly, H2Mab-250 never showed reactivity to non-transformed normal epithelial cells (HaCaT and MCF 10A) and immortalized normal epithelial cells in flow cytometry. In contrast, most anti-HER2 mAbs including H2Mab-119 (IgG1, kappa) reacted with both cancer and normal epithelial cells. The epitope mapping revealed that H2Mab-250 recognized the domain VI of HER2 and the Trp614 mainly contributes to the recognition by H2Mab-250. In immunohistochemical analysis, H2Mab-250 exhibited a superior reactivity to HER2-positive breast cancer section compared to H2Mab-119. Importantly, H2Mab-250 never showed any reactivity to normal tissues by immunohistochemical analysis. The strategy to select cancer-specific mAbs would contribute to the development of novel antibodies and modalities for cancer therapy.
The Issue of Extrusion and Dislocation in Titanium Middle Ear Prostheses: A Literature Review
Authors: Canzi Pietro , Carlotto Elena , Bruschini Luca , Minervini Domenico , Mosconi Mario , Caliogna Laura , Ottoboni Ilaria , Chiapperini Cesare , Lazzerini Francesco , Forli Francesca , Berrettini Stefano , Benazzo Marco
Published: September 2023

Titanium middle ear prostheses are widely used in surgical practice due to their acoustic properties. However, they present a significant drawback shared by all synthetic materials currently in use for middle ear reconstruction: they can be rejected by the organism of the host. In this study, we aim to review the current literature on titanium TORP and PORP extrusion and dislocation. Eighty-one articles were analysed after full article review based on the inclusion and exclusion criteria. The most common indication for reconstruction was chronic otitis media with cholesteatoma. The average extrusion or dislocation rate was 5.1%, ranging from 0 to 35%. The average improvement in air-bone gap was 12.3 dB (1.6 dB to 25.1 dB) and 13.7 (-0,5 dB to 22.7 dB) for PORP ad TORP groups, respectively. The data reported on this topic are highly variable, demonstrating the functional outcomes are difficult to predict in clinical practice. We believe the current limitations could be overcome with technological developments, including bioengineering research focused on promoting the prothesis adaptation to the ME environment.
Yerba Maté (Ilex paraguariensis) Supplement Exerts Beneficial, Tissue-Specific Effects on Mitochondrial Efficiency and Redox Status in Healthy Adult Mice
Authors: Walton Chase M. , Saito Erin R. , Warren Cali E. , Larsen John G. , Remund Nicole P. , Reynolds Paul R. , Hansen Jason M. , Bikman And Benjamin T.
Published: September 2023

Yerba maté, an herbal tea derived from Ilex paraguariensis, has previously been reported to be protective against obesity-related and other cardiometabolic disorders. Using high-resolution respirometry and reverse-phase high-performance liquid chromatography, the effects of four weeks of yerba maté consumption on mitochondrial efficiency and cellular redox status in skeletal muscle, adipose, and liver, tissues highly relevant to whole body metabolism, were explored in healthy adult mice. Yerba maté treatment increased mitochondrial oxygen consumption in adipose, but not in other tissues examined. Yerba maté increased ATP concentration in skeletal muscle and decreased ATP concentration in adipose. Combined with observed changes in oxygen consumption, these data yielded a significantly higher ATP:O2, a measure of mitochondrial efficiency, in muscle and a significantly lower ATP:O2 in adipose, which were consistent with yerba maté-induced weight loss. Yerba maté treatment also altered the hepatic glutathione (GSH)/glutathione disulfide (GSSG) redox potential to a more reduced redox state, suggesting potential protective effects against oxidative stress and preservation of cellular function. Together, these data indicate beneficial, tissue-specific effects of yerba maté supplementation on mitochondrial bioenergetics and redox states in healthy mice that are protective against obesity.