bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative transcriptomics reveals PrrAB-mediated control of metabolic, respiration, energy-generating, and dormancy pathways in Mycobacterium smegmatis
Authors: MAARSINGH JASON D. , YANG SHANSHAN , PARK JIN G. , HAYDEL SHELLEY E
Published: October 2019

Background Mycobacterium smegmatis is a saprophytic bacterium frequently used as a genetic surrogate to study pathogenic Mycobacterium tuberculosis. The PrrAB two-component genetic regulatory system is essential in M. tuberculosis and represents an attractive therapeutic target. In this study, transcriptomic analysis (RNA-seq) of an M. smegmatis ΔprrAB mutant was used to define the PrrAB regulon and provide insights into the essential nature of PrrAB in M. tuberculosis.
Results RNA-seq differential expression analysis of M. smegmatis wild-type (WT), ΔprrAB mutant, and complementation strains revealed that during in vitro exponential growth, PrrAB regulates 167 genes (q < 0.05), 57% of which are induced in the WT background. Gene ontology and cluster of orthologous groups analyses showed that PrrAB regulates genes participating in ion homeostasis, redox balance, metabolism, and energy production. PrrAB induced transcription of dosR (devR), a response regulator gene that promotes latent infection in M. tuberculosis and 21 of the 25 M. smegmatis DosRS regulon homologues. Compared to the WT and complementation strains, the ΔprrAB mutant exhibited an exaggerated delayed growth phenotype upon exposure to potassium cyanide and respiratory inhibition. Gene expression profiling correlated with these growth deficiency results, revealing that PrrAB induces transcription of the high-affinity cytochrome bd oxidase genes under both aerobic and hypoxic conditions. ATP synthesis was ~64% lower in the ΔprrAB mutant relative to WT strain, further demonstrating that PrrAB regulates energy production.
Conclusions The M. smegmatis PrrAB two-component system regulates respiratory and oxidative phosphorylation pathways, potentially to provide tolerance against the dynamic environmental conditions experienced in its natural ecological niche. PrrAB positively regulates ATP levels during exponential growth, presumably through transcriptional activation of both terminal respiratory branches (cytochrome c bc1 - aa3 and cytochrome bd oxidases), despite transcriptional repression of ATP synthase genes. Additionally, PrrAB positively regulates expression of the dormancy-associated dosR response regulator genes in an oxygen-independent manner, which may serve to fine-tune sensory perception of environmental stimuli associated with metabolic repression.
Efficacy of verum and sham acupoint catgut embedding for treatment of obesity: Study protocol for a randomized controlled trial
Authors: zhou yumei , Yan Bing , Yuan Wei-Qu , Yu Hai-Bo , Yang Zhuo-Xin
Published: October 2019

Abstract Background: Obesity has become a major public health hazard with epidemic proportions, influencing adults, adolescents and children of both genders. Previous studies suggested that acupoint catgut embedding (ACE) might be a potential therapeutic approach for obesity. The purpose of this study is to conduct a rigorous and normative trial to determine the efficacy of ACE for obesity. Methods：A total of 99 eligible patients who diagnosed with obesity will be recruited in this study. They will be randomly allocated to either the verum ACE group, sham ACE group, or waiting- list (WL) group with 33 patients for each group. Each patient in the two ACE-based groups will receive 8 sessions of treatment, lasting over 8 weeks. The primary outcomes will the reduction of body mass index (BMI) after treatment. Secondary outcomes will include waist circumference (WC), hip circumference (HC), waist-hip ratio, body fat percentage, blood lipid level, subcutaneous fat area, visceral fat area, and the World Health Organization Quality of Life (WHOQOL). All the outcomes will be evaluated at baseline, ended at 8 weeks of treatments, and 3 months of follow-up. The evaluators and data analyzers will be blinded to group allocation. Discussion: The findings of this randomized, sham- and waiting-list-controlled trial will help to investigate the influence of ACE on clinical variables as well as visceral fat area of obesity, which will provide high-quality evidence on the efficacy of ACE for obesity. Trial registration: Chinese Clinical Trial Registry, ID: ChiCTR1800020248. Registered on November 21, 2018. Keywords: Acupoint catgut embedding, Obesity, Randomized controlled trial, Visceral fat area
Health systems readiness to provide geriatric friendly care services in Uganda: a cross-sectional study
Authors: Ssensamba Jude Thaddeus , Mukuru Moses , Nakafeero Mary , Ssenyonga Ronald , Kiwanuka Suzanne N
Published: October 2019

Background As ageing emerges as the next public health threat in Africa, there is a paucity of information on how prepared its health systems are to provide geriatric friendly care services. In this study, we explored the readiness of Uganda’s public health system to provide geriatric friendly care services in Southern Central Uganda. Methods Four districts with the highest proportion of old persons in Southern Central Uganda were purposively selected, and a cross section of 18 randomly selected health facilities (HFs) were visited and assessed for availability of key items deemed important for provision of geriatric friendly services; as derived from World Health Organization’s Age-friendly primary health care centres toolkit. Data was collected using an adapted health facility geriatric assessment tool, entered into Epi-data software and analysed using STATA version 14. Kruskal-Wallis and Dunn’s post hoc tests were conducted to determine any associations between readiness, health facility level and district. Results The overall readiness index was 16.92 (SD ±4.19) (range 10.8 - 26.6). This differed across districts; Lwengo 17.91 (SD ±3.15), Rakai 17.63 (SD ±4.55), Bukomansimbi 16.51 (SD ±7.18), Kalungu 13.74 (SD ±2.56) and facility levels; Hospitals 26.62, Health centers four (HCIV) 20.05 and Health centers three (HCIII) 14.80. Low readiness was due to poor scores with regard to; leadership (0%), financing (0%), human resources (1.7%) and health management information systems (HMIS) (11.8%) WHO building blocks. Higher level HFs were statistically significantly friendlier than lower level HFs (p= 0.015). The difference in readiness between HCIIIs and HCIVs was 2.39 (p=0.025). Conclusion There is low readiness of public health facilities to provide geriatric friendly care services in Uganda. This is due to gaps in all of the health system building blocks. There is a need for health system reforms in Uganda to adequately cater for service provision for old people if the 2020 global healthy ageing goal is to be met.
Prevalence and intensity of urinary schistosomiasis among school age children in Ikota, Southwestern Nigeria
Authors: Awosolu Oluwaseun Bunmi , Akinnifesi Olufemi Joseph , Salawu Adekola Saheed , Omotayo Yemisi Florence , Obimakinde Ebenezer Tolulope , Olise Christian
Published: October 2019

Schistosomiasis is a water-borne parasitic disease second to malaria in terms of socio-economic importance. Epidemiological data upon which management control could be based is lacking in Ikota, Ondo State, Nigeria. The present study evaluated the prevalence and intensity of urinary schistosomiasis among School age children in Ikota, Ifedore Local Government Area (LGA) of Ondo State, Nigeria. Urine samples were first examined macroscopically for haematuria while reagent strip was used to detect proteinuria after which sedimentation method was used to analyse the samples for characteristic features of the Schistosoma haematobium. Data obtained from the study were analyzed using Pearson's Chi Square Test. A total of 150 subjects were examined, out of which 76 (50.7%) were male and 74 (49.3%) were female. Results obtained from this study revealed a total prevalence of 24% with mean intensity of 21.82 egg/10 mL of urine. The percentage distribution of the infection among the sexes showed that the male students had a lower prevalence of 21.1% of infection than their female counterparts who had 27.0% prevalence with no significant difference (P > 0.05). It was also observed that age group 5-9 had the highest prevalence and mean intensity of 100% and 13.50 egg/10 mL of infection with no significant difference (P > 0.05). In the same vein, sources of water vary significantly among the subjects (p < 0.05). Those who depended on river water (75.0%) had the highest level of infection. Therefore, it is evident that S. haematobium infection is prevalent among the study subjects and appropriate management control strategies should be deployed to the study area.
Effect of administration of neurotransmitters: Serotonin and dopamine on testicular maturation in the freshwater crab Travancoriana schirnerae Bott, 1969 (Crustacea: Gecarcinucidae)
Authors: Gopal Navya , Devi Arath Raghavan Sudha
Published: October 2019

The current investigation aimed at the effect of administration of the neurotransmitters, serotonin and dopamine, on testicular maturation in the freshwater crab Travancoriana schirnerae Bott, 1969 (Crustacea: Gecarcinucidae). Adult males in active, inactive and revival phases of spermatogenesis were injected with serotonin and dopamine in multiple doses and their dissected testes were submitted to histomorphological examinations. Though serotonin treatment during active phase showed increased values for testicular index, acinar diameter and proportion of mature spermatozoa, only the testicular index values differed statistically from that of controls. Serotonin administration during inactive phase caused an increase in testicular index and acinar diameter, reduction in intra and interacinar spaces and pycnosis of germ cells and detection of division stages. A notable increase in the testicular index, acinar diameter and fresh batches of spermatozoa was perceptible in crabs injected with serotonin during revival phase. In contrast, dopamine injection showed a decline in testicular activity irrespective of the phase of spermatogenesis, as evinced from low testicular index, acinar diameter, presence of small, irregularly shaped acini with indistinct acinar boundaries, reduction in the number of mature spermatozoa and absence of division stages. To conclude, the stimulatory neurotransmittant, serotonin can be used to induce testicular maturation in species of aquaculture potential.
Análisis de la Política Nacional de Competitividad y Productividad (2008-2014): oportunidades para el sector apícola colombiano
Authors: Rincón Yara Daniel Fernando
Published: October 2019

Los entornos en los que las empresas desarrollan sus actividades están demarcados por las acciones estatales que se materializan a partir de los planes de acción de políticas públicas, que en la mayoría de los casos no son conocidos por parte de las directivas de las empresas. El objetivo de este trabajo es analizar la Política Nacional de Competitividad y Productividad entre los años 2008 y 2014 para identificar posibles oportunidades para el sector apícola colombiano. De los quince planes de acción de dicha Política Pública, uno atiende el sector agropecuario y dentro del mismo, tres de los cuatro ejes estratégicos que lo desarrollan ofrecen acciones gubernamentales que representan oportunidades para el sector apícola colombiano, especialmente para el eslabón primario de la cadena de producción. A pesar de ello, el impacto de los mismos debe ser cuantificado por las organizaciones gremiales del sector apícola colombiano.
Risk factors for the return of mitral insufficiency after coronary artery bypass graft and reconstruction of the mitral valve in patients with ischemic cardiomyopathy
Authors: Kareva Yu. , Efendiev V. , Rakhmonov S. , Chernyavskiy A. , Lukinov V.
Published: October 2019

Aim. This study aimed to compare the surgical correction results for isolated coronary artery bypass graft (CABG) and CABG in combination with mitral valve (MV) repair for moderate ischemic mitral insufficiency (IMI) in patients with ischemic cardiomyopathy and to identify the risk factors for MI return.Methods. This single-centre prospective study enrolled 76 patients with ischemic cardiomyopathy and moderate MI with a left ventricular ejection fraction < 35% who did not undergo left ventricular reconstruction. The patients were treated with isolated CABG or CABG in combination with MV repair. The mean age of the patients was 57.5 ± 8.6 years (range, 30–75 years), and 90% were men. Isolated annuloplasty was used with a rigid support ring brand with a ring size of 26–30 mm to correct mitral insufficiency in the CABG + MV repair group.Results. We found that isolated CABG or CABG + MV repair in patients with ischemic heart disease and severe systolic left ventricular dysfunction does not result in significant decrease in the MI in the long term compared with that at baseline. However, the degree of MI after CABG + MV repair is lower than the initial values, unlike that after isolated CABG 12 months postoperatively. In the observation period, of up to 36 months, the MI degree after isolated CABG corresponds to the initial values. The determination of the predictors of IMI progression in ischemic cardiomyopathy enabled us to determine the threshold values of the performance indicators of MV repair, and the evaluation of Echo predictors for annuloplasty preoperatively help select the surgical treatment strategies for patients with ischemic cardiomyopathy and moderate MI.Conclusion. Correction of IMI in patients with ischemic cardiomyopathy does not increase the number of complications in the early postoperative period compared to isolated CABG (p = 0.015). After isolated CABG in patients with ischemic cardiomyopathy and moderate MI, progression of mitral regurgitation (grade 3 mitral regurgitation, initially 0%; after 12 months, 31%; after 36 months, 71%; p < 0.001) is observed even with initially moderate changes in the geometry of the mitral valve.Received 6 December 2018. Revised 25 March 2019. Accepted 28 March 2019.Funding: The study did not have sponsorship.Conflict of interest: Authors declare no conflict of interest.
Evaluation of Antileishmanial Activity Employing Conventional and Solid Lipid Nanoparticles of Amphotericin B on Leishmania major In Vitro and In Vivo
Authors: Soltani Shahrzad , Mojiri-Forushani Hoda , Soltani Sheyda , Kahvaz Mehdi Sagha , Foroutan Masoud
Published: October 2019

Background:

Obligate intracellular parasites of Leishmania genus belong to the family
Trypanosomatidae and more than twenty species cause this neglected vector-borne infection
throughout the globe.

Objective:

The current study was aimed to assess the antileishmanial activity of Amphotericin B
(AmB) and AmB formulated into solid lipid nanoparticles (SLNs) in vitro and in vivo.

Materials and Methods:

In the present research, microemulsification and high shear homogenization
methods were used to prepare SLNs. Leishmania major (L. major) promastigotes were cultured
in RPMI 1640 and incubated for three time points of 24, 48 and 72 h at 25±1°C. Then, the
MTT colorimetric assay was employed for obtaining 50% inhibitory concentration (IC50). Finally,
the efficacy of AmB and AmB-SLN was evaluated for the treatment of experimental cutaneous
leishmaniasis (CL) in BALB/c mice.

Results:

The average diameter sizes of prepared AmB-SLN were <180 nm and monodisperse
preparations with polydispersity index 0.21±0.29. The antileishmanial activity of AmB and AmBSLN
revealed a dose and time-dependent manner in vitro. The IC50 values of AmB (38.18±1.33,
25.06±2.00, and 13.87±0.61 μg/ml) and AmB-SLN (0.40±0.02, 0.26±0.02, and 0.14±0.01 μg/ml)
were estimated after 24, 48 and 72 hours, respectively. In all BALB/c treatment groups, the diameter
of lesions was significantly smaller than the control group.

Conclusion:

AmB-SLN was significantly more potent than AmB in vitro and in vivo. The discovery
of new effective drugs based on nanocarriers, such as SLN, is practical and opens a new window
for the treatment of CL.
A Detailed Insight of the Anti-inflammatory Effects of Curcumin with the Assessment of Parameters, Sources of ROS and Associated Mechanisms
Authors: Wal Pranay , Saraswat Nikita , Pal Rashmi Saxena , Wal Ankita , Chaubey Madhvi
Published: October 2019

Background:

Curcumin is an active constituent ofCurcuma longa,which belongs to Zingiberaceae family. It is derived from the Rhizome of a perennial plant having molecular formula C21H20O6and chemically it is (1, 7- bis (4- hydroxy - 3 methoxyphenyl) -1, 6 - heptadine - 3, 5 - diene), also known as diferuloylmethane. Curcumin has been extensively used as a herbal constituent for curing several diseases and is scientifically proven to show major effects as an anti-inflammatory agent.

Objective:

Inflammation is an important factor for numerous diseases including diabetes neuropathy, cancer, asthma, arthritis, and other diseases. Prophylaxis of inflammatory diseases through synthetic medications tends to have major toxicity and side effects on a large number of population. The foremost aim of this review paper is to assess the natural anti-inflammatory effect of curcumin, source, and mechanism of action, potential therapeutic effect and models associated. Additionally, this paper aims to scrutinize inflammation, sources of reactive oxygen species, and pathways of reactive oxygen species generation and potential side effects of curcumin.

Methods:

Selection of data has been done by studying the combination of research and review papers from different databases like PubMed, Medline and Web of science from the year 1985- 2018 by using search keywords like “curcumin”, “anti-inflammatory”, “ROS”, “Curcuma longa”, “medicinal uses of curcumin”, “assessing parameters”, “inflammation”, “anti-oxidant”

Results:

On the basis of our interpretation, we have concluded that curcumin has potential therapeutic effects in different inflammatory diseases, it inhibits the inflammatory mediators, oxidation processes, and oxidative stress and has no severe toxicity on animals and humans.

Conclusion:

Oxidative stress is a major cause of inflammation and curcumin has a good potential for blocking it. Curcumin is also easily accessible herbal source and should be consumed in the form of food, antioxidant, anti-inflammatory agents and further observation should be done on its therapeutic parameters, risk factors, and toxicity studies and oral viability.
The Motivation of Russian and Kazakhstani Faculty Members in the Cross-Cultural Context
Authors: Turgumbayeva Aizhan , Aimaganbetova Olga , Kassymova Roza , Yeralina Elmira , Bakirova Zhanat
Published: October 2019

Background & Objective:

The motivation of university faculty members in a cross-cultural context is one of the main issues in the context of internationalization of higher education. This research aims to explore if there are significant differences in motivational drivers between Kazakhstani and Russian university faculty members based on their cultural background.

Methods:

The research involves 158 university faculty members from Kazakhstan and Russia. The research applies cross-survey methodology.

Results:

The findings on the main motivational themes show that Kazakhstani university faculty members have a higher orientation to security and stability and integration of lifestyle. Russian university faculty members have higher levels of autonomy, challenge and entrepreneurship.

Conclusion:

The conducted research presented the main motivational drivers of Kazakhstani and Russian faculty. It is evident that Kazakhstani and Russian university faculty members have significant differences in motivational profiles, despite the shared Soviet past. Research showed that Russian faculty is motivated by creativity and challenges, whereas their Kazakhstani counterparts seem to be more focused on the security and work-life balance. Nevertheless, the occupational peculiarities show similarities in the attitudes to money and power.
Development of a Core Set of Patient-Reported Outcomes for Population-Based Cancer Survivorship Research: Protocol for an Australian Consensus Study
Authors: Ramsey Imogen , Corsini Nadia , Hutchinson Amanda D , Marker Julie , Eckert Marion
Published: October 2019

Background

Core outcome sets seek to improve the consistency and quality of research by providing agreed-upon recommendations regarding what outcomes should be measured as a minimum for a population and setting. The problems arising from a lack of outcome standardization in population-based cancer survivorship research indicate the need for agreement on a core set of patient-reported outcomes (PROs) to enhance data quality, consistency, and comparability.

Objective

This study aims to identify a core set of PROs, representing the most important issues impacting on cancer survivors' long-term health, functioning and quality of life, to inform population-based research on cancer survivorship.

Methods

In Phase I, a list of all potentially important outcomes will be generated through focus group discussions with cancer survivors and a review of measures for assessing quality of life in cancer survivorship. The consolidated list will be advanced to Phase II, where a stakeholder consensus process will be conducted with national experts in cancer survivorship to refine and prioritize the outcomes into a core outcome set. The process will consist of a two-round Delphi survey and a consensus meeting. Cancer survivors, oncology health care professionals, and potential end users of the core outcome set with expertise in cancer survivorship research or policy will be invited to participate. In Phase III, recommended measures for assessment of the core outcome set will be selected with advice from experts on the assessment, analysis, and interpretation of PROs.

Results

As of April 2019, data collection for Phase I is complete and data analysis is underway. These data will inform the list of outcomes to be advanced into Phase II. Recruitment for Phase II will commence in June 2019, and it is anticipated that it will take 6 months to complete the three-step consensus process and identify a provisional core outcome set. The study results are expected to be published in early 2020.

Conclusions

Expert consensus-driven recommendations on outcome measurement will facilitate the inclusion of survivorship outcomes considered important by cancer survivors and health professionals in future research. Adoption of the core outcome set will enable comparison and synthesis of evidence across studies and enhance the quality of PRO data collected in cancer survivorship research, particularly when applied to address macro-level questions.

International Registered Report Identifier (IRRID)

DERR1-10.2196/14544
Voices in Evidence-Based Newborn Care: A How-to-Guide on Developing a Parent-Facing Podcast
Authors: Parga-Belinkie Joanna , Merchant Raina M
Published: October 2019

Podcasting is becoming a more popular form of media. Its use in medical education is being researched—but what about its use in public education? In this tutorial, the authors offer a how-to-guide on starting a public or patient-facing podcast. The authors hope to inspire more physicians to utilize this type of media to share evidence-based information. More research is needed looking into how podcasting can be used to help with patient education.
Nurse Coaching and Mobile Health Compared With Usual Care to Improve Diabetes Self-Efficacy for Persons With Type 2 Diabetes: Randomized Controlled Trial (Preprint)
Authors: Young Heather M , Miyamoto Sheridan , Dharmar Madan , Tang-Feldman Yajarayma
Published: October 2019

BACKGROUND

Type 2 diabetes is a growing public health problem amenable to prevention and health promotion. As healthy behaviors have an impact on disease outcomes, approaches to support and sustain diabetes self-management are vital.

OBJECTIVE

This study aimed to evaluate the effectiveness of a nurse coaching program using motivational interviewing paired with mobile health (mHealth) technology on diabetes self-efficacy and self-management for persons with type 2 diabetes.

METHODS

This randomized controlled trial compared usual care with an intervention that entailed nurse health coaching and mHealth technology to track patient-generated health data and integrate these data into an electronic health record. The inclusion criteria were as follows: (1) enrolled at 1 of 3 primary care clinics, (2) aged 18 years or above, (3) living with type 2 diabetes, and (4) English-speaking. We collected outcome measures at baseline, 3 months, and 9 months. The primary outcome was diabetes self-efficacy; secondary outcomes were depressive symptoms, perceived stress, physical functioning, and emotional distress and anxiety. Linear regression mixed modeling estimated the population trends and individual differences in change.

RESULTS

We enrolled 319 participants; 287 participants completed the study (155 control and 132 intervention). The participants in the intervention group had significant improvements in diabetes self-efficacy (Diabetes Empowerment Scale, 0.34; 95% CI –0.15,0.53; P<.01) and a decrease in depressive symptoms compared with usual care at 3 months (Patient Health Questionnaire-9; 0.89; 95% CI 0.01-1.77; P=.05), with no differences in the other outcomes. The differences in self-efficacy and depression scores between the 2 arms at 9 months were not sustained. The participants in the intervention group demonstrated a significant increase in physical activity (from 23,770 steps per week to 39,167 steps per week at 3 months and 32,601 per week at 9 months).

CONCLUSIONS

We demonstrated the short-term effectiveness of this intervention; however, by 9 months, although physical activity remained above the baseline, the improvements in self-efficacy were not sustained. Further research should evaluate the minimum dose of coaching required to continue progress after active intervention and the potential of technology to provide effective ongoing automated reinforcement for behavior change.

CLINICALTRIAL

ClinicalTrials.gov NCT02672176; https://clinicaltrials.gov/ct2/show/NCT02672176
José Vasconcelos: mito iberoamericanista o filosofía estética iberoamericana
Authors: Luquín Guerra Roberto
Published: October 2019

Apart from his political and educational work, and from his controversial autobiography, José Vasconcelos is known for his Ibero-Americanist thought. The Cosmic Race, Indology and Bolivarism and Monroeism gather all the ideas that are attributed to his theoretical point of view. His philosophy is what we know less of and what is most criticized. Nonetheless, is there a connection between his philosophical thought and his Ibero-Americanist ideas? Abelardo Villegas says that Vasconcelos’s philosophy is the product of a racial and cultural message. Therefore, according to Villegas, his philosophy is subordinated to his Ibero-Americanist ideas. Patrick Romanell, on the other hand, states that the Ibero-Americanist ideas make up the popular and illusory side and, hence, must be separated from the philosophical thought. The aim of this paper is to elucidate this problem. In order to clarify it, we will follow Villegas viewpoint to the bitter end. His reasoning invites us to look closely at the history of Ibero-American thought as well as at Vasconcelos’s first works. Precisely by analyzing these two aspects and the point where they meet, we might be able to find an answer.
Del individuo o de la producción aleatoria. Notas de investigación sobre el pensamiento de Louis Althusser
Authors: Barrón Tovar José Francisco
Published: October 2019

Four effects, I think, should be forced upon us in the re-reading of Althusser: 1) the concept of revolution that is put into operation to determine the exercise of politics, 2) the distinction between subject and individual to specify the practices of the political subjectivation, 3) the importance of language in thought and practice to make possible a different way of thinking, and 4) the insistence on a random-productive nature of the body to allow the production of the new.
La noción de tradición y la reflexión sobre la historia de la filosofía mexicana
Authors: Rodríguez Soriano Roberto Israel
Published: October 2019

In this essay, I argue to support that the concept of Tradition has an important meaning for our philosophical reflection. This concept has ontological and epistemological support, and understand it in this way give us perspectives and possibilities to our philosophical exercise from our own existential position. Nevertheless, the reflection must be made whit a hermeneutic exercise, which only can start from the history of the philosophy.
Purificación y sacrificio. El orfismo y su herencia dionisiaca-apolínea
Authors: Lomelí Bravo Eduardo Sebastián
Published: October 2019

The quest for the divine in humankind led the orphics to gather around the form of Dionysus. However, this cult was reformed from an Apollonian point of view, which allowed believers to eliminate the bacchic rituals and the particular sanguinary sacrifices demanded by such divinity. These changes can be explained, as shown in this article, by the concept of purity that Orpheus’ followers had.
Memoria y mirada. El sentido del tiempo en Ararat de Atom Egoyan
Authors: Lizarazo Arias Diego
Published: October 2019

Based on the idea that filmmaking is a way to “make time”, in this essay, the author asks, with a wide contextualization film, what is the sense of time in Atom Egoyan’s Ararat?
Idealismo y fundamentación
Authors: Guarneros Monterrubio Aldo
Published: October 2019

The aim of this essay is to understand the sense of the inquiry into ideas in modern philosophy and, so, to clear up the prejudices about the idealism, which will be set out here in broad outline. In order to achieve this comprehension I make an effort to clarify what does historical groundwork of the truth and the principleof unity in idealism involve. I start from the hypothesis that the groundwork does not consist in imposing a reason in itself —beyond the world—, but in showing it. In other words, despite the common interpretation of modern philosophy, I hold that the aim of idealism is to display the foundation, but not subjectively. So, probably the whole philosophical determination, explained from this point of view, could be understood not only as the inquiry into the principle of knowledge, but as the questioning about the principle of unity, that is to say, recognize what is manifest by itself.
¿Por qué la arquitectura es música congelada? Schelling, Le Corbusier y Xenakis
Authors: López-Domínguez Virginia
Published: October 2019

Architecture is frozen music is a phrase which has been transformed by use, but it has also been taken away the importance it has for an esthetic ontology and a different conception of the world, and that is why its deepness and meaning are analyzed through Schelling, Le Corbusier and Xenakis in order to show why architecture is frozen music. Here architecture and music have a correlation that cannot be perceived at first, which places architecture itself in a quest for beauty, when in the past it only used to be taken into account in the criteria of the useful. The narrow connection between architecture and music dwells on the level of a priori regarding structure and mathematics, but also shows the relation with the sensitive, the real and the ideal, which means that it involves the fluctuation between the objective and the subjective that can be shown regarding the execution of the work.
El caso Hegel. Sobre el "Prólogo" a Fenomenología del espíritu
Authors: Morales Domínguez Mario
Published: October 2019

This paper is a critical review of the Preface in Hegel’s Phenomenology of Spirit. Its aim is to show how the development of Hegel’s work, always in search of the reason, ends up getting close to madness and, in consequence, reveals some negative features of the human being. To achieve this objective, a series of analogies supported in later authors are constructed. These are: psychosis in the Schreber case, on Freud; sacrifice and death, on Bataille; and syncope and photography as resources for the proposed approach to Nancy. Finally, it is proposed that the work of Hegel can be used to understand current philosophy as a labor of raving, a task which involves both retake and denial of Hegel’s work, and even forgetting it.
Del vínculo trascendental entre la modernidad, lo barroco y lo romántico
Authors: Gerardo Rivas Víctor
Published: October 2019

This dissertation contains an introduction and three sections. In the former I explain the import of the concepts that I use here so as to show that the baroque and the romantic have a philosophical relevance because they show each to its own the difference of subjectivity and nature that is the starting point of Modernity. In the first section I reconstruct the Cartesian project of a methodical certainty that overcomes the contradictions of the ancient metaphysics and I show too why that project implies a conflictive relation between the representation and the sensitivity that contradicts it through the deceitful seductiveness of images and the force of time that devastates any sense. In the second section, I show that this leads us to the baroque, that I consider a way for represent the tension between subjectivity and absolute temporality. In the last section I do the same regarding the romantic, which I take as the experience of the desiderative complexity of the subject.
Reflexiones sobre ethos barroco y guadalupanismo
Authors: Mejía Vergara Omar
Published: October 2019

Taking as starting point the mexican tradition about the virgin of Guadalupe as a clear example of the “baroque behavior”, a proposal made by Bolívar Echeverría, the present text discusses the emphasis that this author gives to the indigenous aspect of the phenomenon. In this way, the paper seeks to include into the analysis in key of baroque ethos also the presence of creole thinkers; specially, with the importance of the called “evangelists of Guadalupe”, a group of four authors from the seventeenth century, who configurated intelectually this worship in the New Spain. Thus, continuing Echeverría’s original line, the final part of the text proposes a new aplication of his baroque ethos in processes and events ocurred in New Spain during seventeenth century, because some are very important to understand the mexican mode of being.
Anacronismo, stásis y el olvido de la democracia: las Erinias al pie del Areópago
Authors: Hernández Cuevas Luis Armando
Published: October 2019

Taking into account the anachronistic method embraced by Nicole Loraux, the essay attempts to experience how is that the δασμός ἐς τὸ μέσον (“that which is deposited in the center”) is constituted as the hinge that established as foundation, pleads for the forgetfulness of the political as conflict, that is, of the στάσις. In this sense, these lines inquire: what does forgetting the στάσις imply for democracy?
El retorno antimoderno. Mito y teología política en tiempos postseculares.
Authors: Álvarez Solís Ángel Octavio
Published: October 2019

The main argument of this essay highlights the political importance of the myths regarding the formation of the modern debate around secularization, especially the role that political myths and theologies play in the configuration of the modernity. The essay is divided in three parts. The first one supports that the political myth constitutes the blind point of modernity; the second one emphasizes why it is impossible to explain secularization without the help of politic theology, and the third one describes the return of theological thought in the current debates on secularization.
Argumentos y explicaciones causales ordinarios: distinción teórica
Authors: Ramos Villegas Pedro Arturo
Published: October 2019

In this paper I will try to show in its main lines, from some of Frege’s and Margáin-Davidson’s thesis, the theoretical framework from which we can draw the distinction between ordinary reasonings and causal explanations. Such framework clearly arises observing that reasonings and explanations belong to different kinds of linguistic objects, and that there are at least four different types of explanations corresponding to four different senses of the term ‘cause’: cause as (necessary and/or sufficient) condition and cause as causal event. This emerges from such drawing: explanations presupposing the notion of cause in the conditional sense are reducible to reasonings; but not those presupposing it in the sense of causal event. The main point of all of this resides in the enormous similitude that exists between ordinary reasonings and explanations, and in that it has been sustained, inside the subject’s literature (remarkably in Hempel), that such explanations, being just a kind of enthymematic reasoning, are necessarily incomplete, provisional or mere sketches needed of justification; but they are not. The picture that eventually emerges on such distinctions is this: ordinary reasonings and explanations are two relatively distinct types of discourses with a vast common zone of intersection, but with huge disjunct or detached zones between them too.
Platonismo matemático sin metafísica: nuevas luces sobre la objetividad en Gottlob Frege y Kurt Gödel
Authors: Da Silva Araujo Ricardo José
Published: October 2019

The main purpose of the present paper consists in analyzing the arguments, interpretations and concepts offered by both Gottlob Frege and Kurt Gödel in some of their works in defense of platonic realism in mathematics, where they do not rely on epistemologically complex concepts such as the world of Ideas or an intellectual intuition.
La visión de Carmen Rovira sobre la filosofía mexicana
Authors: Velasco Gómez Ambrosio
Published: October 2019

The main purpose of this paper is to interpret the main contributions of Carmen Rovira to the study of the historical development of Mexican philosophy in its hermeneutical aspects as well as in the rescue and interpretation of the original works of Mexican philosophers since the XVI Century. In first place I analyze her hermeneutical methodology for the history of Mexican philosophy that highlights the importance of interactions between texts and contexts. Secondly, I refer to the archives rescue made by Carmen Rovira to reconstruct a Mexican philosophical corpus, especially for XIX and XX centuries. But the most relevant ofCarmen Rovira’s philosophical work is her original and critical interpretations of Mexican and Iberoamerican works, both from colonial and independent period. The most outstanding thesis of these interpretations is that during the colonial epoch Mexican philosophy was determinant for the construction of an idea of authentic nation that was very important for Mexican independence in the first decades of Nineteenth Century. Unfortunately, after Mexican independence the great cultural and political relevance of Mexican philosophydecayed. The most outstanding contribution of Carmen Rovira is precisely to recover the cultural and political relevance of philosophy in present Mexico.
PENGARUH MODEL PEMBELAJARAN CONTEXTUAL TEACHING AND LEARNING TERHADAP HASIL BELAJAR MATEMATIKA SISWA
Authors: Rahmawati Tanti Diyah , Wahyuningsih Wahyuningsih , Dua Getan Maria Amaranta
Published: October 2019

Pengaruh Model Pembelajaran Contextual Teaching And Learning Terhadap Hasil Belajar Matematika Siswa Di SMA Negeri 2 Maumere. Penelitian ini bertujuan untuk mengetahui ada tidaknya pengaruh model pembelajaran Contextual Teaching And Learning (CTL) terhadap hasil belajar matematika siswa. Penelitian ini dilakukan di SMA Negeri 2 Maumere pada  semester genap tahun ajaran 2016/2017. Metode yang digunakan adalah metode experimen. Populasi pada penelitian ini adalah seluruh siswa kelas X sedangkan sampelnya yaitu kelas XG sebagai kelas eksperimen yang berjumlah 33 siswa dan kelas XE sebagai kelas kontrol yang berjumlah 35 siswa. Teknik sampling menggunakan cluster random sampling. Teknik pengumpulan data menggunakan tes dan dokumentasi. Setelah data berdistribusi normal dan homogen berdasarkan uji normalitas yakni uji Chi kuadrat dan uji homogenitas yakni uji fisher, maka dilanjutkan dengan pengujian hipotesis. Uji  hipotesis menggunakan uji t. Hasil uji t pada taraf signifikansi 0.05, menunjukkan bahwa nilai thitung> ttabel (5,367 > 1,6697), ini berarti Ho ditolak dan Ha diterima sehingga disimpulkan bahwa ada pengaruh model pembelajaran CTL terhadap hasil belajar matematika siswa
Protección de los niveles sociales y Recomendación de la OIT Nº 202
Authors: Dodera José Luis
Published: October 2019

A partir de la aprobación de la Recomendación 202 (en adelante, R 202), por la Conferencia General del Trabajo, de la OIT en el año 2012, dirigida a los países miembros de la organización para la aprobación de medidas para construir pisos de protección social, dentro del marco de trabajo decente, entendemos que surgieron obligaciones para Uruguay, donde se pueden delinear dos ejes de trabajo básicos: a) la emersión del trabajo informal, no declarado o no registrado, la transición del trabajo informal, no declarado o no registrado hacia el trabajo formal, y b) la promoción del trabajo productivo y del empleo. En estos dos ejes, las cooperativas de trabajo y las cooperativas de producción constituyen instrumentos idóneos y tienen un papel relevante para completar la construcción del piso social.
Aportes normativos, institucionales y sociales a la gestión del agua
Authors: Ferro Mariano , Minaverry Clara María
Published: October 2019

Este trabajo contribuye al avance en el estado de conocimiento sobre los aspectos normativos, institucionales y sociales de la gestión ambiental, específicamente vinculados al enfoque ecosistémico de la cuenca del Río Luján. Se recurre al análisis legal y jurisprudencial de los servicios de los ecosistemas, de medios gráficos y la implementación de las encuestas de los ciudadanos. Se puede concluir que se ha detectado un escenario jurídico-institucional signado por el solapamiento normativo y la superposición de competencias y jurisdicciones. En ese contexto, las normas jurídicas de menor jerarquía – las ordenanzas municipales – son las que han incorporado con mayor profundidad el enfoque ecosistémico a sus textos. Respecto de las percepciones sociales de los servicios de los ecosistemas, el análisis de los medios gráficos nos ha permitido identificar que se encuentran escasamente visibilizados, y fundamentalmente asociados a la acción de grupos ambientalistas locales.
Veinte años
Authors: Risso Ferrand Martín
Published: October 2019

La Revista de Derecho cumple 20 años
GENE PREDICTION IN HETEROGENEOUS CANCER TISSUES AND ESTABLISHMENT OF LEAST ABSOLUTE SHRINKAGE AND SELECTION OPERATOR MODEL FOR LUNG SQUAMOUS CELL CARCINOMA
Authors: MUHAMMED KHALIQ ATEEQ , SHARATHCHANDRA R G  , RAJAMOHAN MEENAKSHI
Published: October 2019

This study is aimed to establish a Least Absolute Shrinkage and Selection Operator (LASSO) model based on tumor heterogeneity to predict the best features of LUSC in various cancer subtypes. The RNASeq data of 505 LUSC cancer samples were downloaded from the TCGA database. Subsequent to the identification of differentially expressed genes (DEGs), the samples were divided into two subtypes based on the consensus clustering method. The subtypes were estimated with the abundance of immune and non-immune stromal cell populations which infiltrated the tissue. LASSO model was established to predict each subtype's best genes. Enrichment pathway analysis was then carried out. Finally, the validity of the LUSC model for identifying features was established by the survival analysis. 240 and 262 samples were clustered in Subtype-1 and Subtype-2 groups respectively. DEG analysis was performed on each subtype. A standard cutoff was applied and in total, 4586 genes were up regulated and 1495 were down regulated in case of subtype-1 and 5016 genes were up regulated and 3224 were down regulated in case of subtype-2. LASSO model was established to predict the best features from each subtype, 49 and 34 most relevant genes were selected in subtype-1 and subtype-2. The abundance of tissue-infiltrates analysis distinguished the subtypes based on the expression pattern of immune infiltrates. Survival analysis showed that this model could effectively predict the best and distinct features in cancer subtypes. This study suggests that unsupervised clustering and LASSO model-based feature selection can be effectively used to predict relevant genes which might play an important role in cancer diagnosis.
Sosialisasi Panduan Elektronis Pembelajaran Tajwid Berbasis Macromedia Flash (Tempat : Pondok Pesantren Modern Islam Assalaam Surakarta)
Authors: Rakhmadi Aris , Kurniawan Ady Purna
Published: October 2019

The purpose of this research is to develop and test an electronic learning system asan alternative learning media to read Al-Qur’an. The creation of this learning systemhas through some steps. The steps are references searching, data collecting, systematic creating, and testing. This process involves data collecting from tajwid books and video recording. The capacity of this system is 179 MB including 1.655 files consisting of 1 .exe file. 769 .swf files, 734 .flv video files, 151 mp3 files, and 3 folders. The resulted video has an extention .flv which has a size as big as 250 x 180 pixel. Frame Rate 15 fps, and Bit Rate 260 kbps. The resulted audio extents mp3 that has a Bit Rate 128 kbps, stereo channel and resolusion 16 bit. The questioners that are devided to the 20 users show that this programm is better and completer than tajwid books sold.
Saberes sensíveis na saúde mental - Contribuições de Reggio Emília para uma pesquisa a/r/tográfica
Authors: Rodrigues Junior André José
Published: October 2019

Em 2018, iniciamos uma pesquisa exploratória no Centro de Atenção Psicossocial 3, do município de Suzano, com objetivo de observar o quanto a arte poderia contribuir como forma de expressão para ampliar a interação social de pessoas com transtornos mentais graves. Nosso principal dificuldade na pesquisa foi observar cientificamente aspectos tão subjetivos quanto a experiência estética dos pacientes e as interações sociais que puderam ser intensificadas por essas experiências. Esse artigo trata sobre os caminhos encontrados para pensar uma pesquisa que inclua os aspectos subjetivos da experiência estética e das interações sociais a partir da relação entre a abordagem pedagógica de Reggio Emília e a a/r/tografia como abordagem metodológica. Acreditamos que essa relação pode contribuir para outras pesquisas no campo da arte e da educação, apontando algumas possibilidades da a/r/tografia como uma abordagem híbrida e suas as relações com a pedagogia da escuta, de Reggio Emilia.