bluuebunny/crossref_metadata_2025 huggingface dataset:
Changes in the composition of proteins in the blood during the period of ischemia-reperfusion syndrome, modeled by a violation of blood flow in the liver
Authors: Garayev G Sh , Gafarova J R , Jafarova R E
Published: July 2021

On the experimental model of liver ischemia-reperfusion, quantitative changes in protein composition in the blood of white outbred rats were investigated. It was found that against the background of a 10-minute ischemia, the total protein content decreased by 0,9%, albumins by 1,5% (p0,05). The content of globulins practically did not change, and the content of fibrinogen increased by 33,3% (p0,05). In the corresponding periods of reperfusion compared with intact values, the content of total protein and albumins decreased, and globulins and fibrinogen increased. The intensity of changes in the quantitative and qualitative content of proteins in the blood of animals depended on both the duration of the ischemia period and the duration of reperfusion. At the same time, the increase in the level of globulins in the blood occurred more intensively during reperfusion after 20 minutes of ischemia. Thus, against the background of ischemia, there are changes in the quantitative composition of plasma proteins (total protein, albumins, globulins, fibrinogen). As the duration of ischemia increases, pathological changes increase. With reperfusion, the process continues unidirectionally, but against the background of a deeper ischemia lasting 20 minutes, some parameters of the pathological changes in the blood composition are less pronounced than against a background of reperfusion after a 10-minute ischemia. This phenomenon is explained by the activation of the protective and adaptive functions of the body.
Clinical characteristics of different nationalities, who committed suicide attempts and were hospitalized in a psychiatric hospital
Authors: Mekhtiyev E S , Abbasova S E , Kasimov O G , Dnov K V
Published: July 2021

The clinical characteristics of persons of Talysh and Lezghin nationalities who committed suicide attempts and were hospitalized in this regard in a psychiatric hospital are analyzed. It was established that among the suicides of the Talysh nationalities the largest were the shares of people who had suicidal actions in response to severe stress and adaptation disorders, as well as organic mental disorders (32,4% each). Significantly less frequent were patients with personality and behavior disorders - 13,7% (χ2=8,96; p=0,003), schizophrenia, schizotypic and delusional disorders - 8,8% (χ2=15,86; p0,001). Among the psychiatric disorders, the psychiatric hospital of the Lezghin nationality was dominated by organic mental disorders (27,7%) among suicidal patients. Less common were personality and behavioral disorders at a young age of18,5% (χ2=1,08; p=0,29); schizophrenia, schizotypic and delusional disorders - 15.4% (χ2=2,23; p=0,135) and psychiatric and psychiatric substance abuse disorders - 12,3% (χ2=3,89; p=0,048). Officers of the Talysh and Lezghin nationalities resorted to poisoning with equal frequency - 82,1 and 81,8%, less often - firearms - 13,4% (χ2=92,7; p0,001) and 13,7% (χ2=89, 9; p0,001); hanging - 4,5% (χ2=117,5; p0,001). Talysh rank and file officers often chose hanging and poisoning- 42,9 and 40%; less often they caused gunshot injuries - 17,1% (χ2=4,35; p=0,036). Lezgin’s soldiers used gunshot wounds more often - 42,9%, less often poisoning - 33,3% (χ2=0,1; p=0,75) and hanging - 23,8% (χ2=0,32; p=0,96). In general, the incidence of suicides in mentally ill patients depends on the combination of the following factors: the prevalence rate of suicides in the general population; ethnicity of patients; level of organization and access to psychiatric care. Various combinations of these factors determine the prevalence of suicide among patients with mental disorders.
Efficiency of inosine glycyl-cysteinyl-glutamate disodium and pyridoxine in acute poisoning by unsymmetrical dimethylhydrazine
Authors: Antushevich A E , Basharin V A , Reynyuk V L , Bugaev P A
Published: July 2021

Effectiveness of pyridoxine hydrochloride and inosine glycyl-cysteinyl-glutamate dinatrium (molixan) in monotherapy and in combination in acute poisoning by unsymmetrical dimethylhydrazine on survival, blood biochemical indicators and the state of plasma coagulation hemostasis was assessed. Unsymmetrical dimethylhydrazine was administered intraperitoneally at a dose of 115 mg/kg (LD50) once. Drugs under examination were also admistered intraperitoneally: pyridoxine hydrochloride in a dose of 50 mg/kg once, 30 minutes after the administration of unsymmetrical dimethylhydrazine, the inosine glycyl-cysteinyl-glutamatedinatrium (molixan) in a dose of 60 mg/kg seven times: 30 minutes after the administration of unsymmetrical dimethylhydrazine, and then daily for 6 days. Biochemical parameters of blood, plasma coagulation hemostasis, were evaluated 7 days after the administration of unsymmetrical dimethylhydrazine. The use of pyridoxine as a monotherapy and in combination with molixan prevents death of experimental animals and the development of convulsive syndrome. In addition, the combination of molixan with pyridoxine eliminates the development of toxic lesions of liver that is having hepatoprotective effect. The efficiency of molixan as hepatoprotector, apparently, related to the fact that in its structure it is a combined preparation containing the peptide and purine components. The peptide component (glycyl-cysteinyl-glutamate dinatrium) is a pharmacological analogue of oxidized glutathione, purine is represented by inosine. Oxidized glutathione has cytoprotective activity, inhibits the cytolysis of hepatocytes, and reduces the severity of inflammatory process during toxic damage of liver cells by the products of metabolism of xenobiotics. Inosine also has hepatoprotective properties. As a precursor to the synthesis of adenosine triphosphoric acid and nucleotides, it stimulates a number of metabolic processes in body, supports energy balance in various tissues, particularly in liver and myocardium.
Evaluation of the effectiveness of single session audiovisual stimulation for the organism functional state’s correction
Authors: Sysoev V N , Chebykina A V , Dushkina M A , Dergachev V B
Published: July 2021

Based on the analysis of the changes in the bioelectrical activity of the brain, the dynamics of cerebral blood flow and the vegetative balance of the body, the efficacy of a single 15-minute session of audiovisual stimulation for the correction of the functional state of the organism was evaluated. It was found that after the audiovisual stimulation session, the mean value of the alpha-rhythm power in the frontal, anterior-parietal and occipital leads of the right and left hemispheres of the brain was statistically significant more than in the background study. Such a change in the power of the alpha-rhythm reflects the level of ascending activation necessary for the organization of adaptive behavior, and can also characterize the intensity of the neuro-emotional stress. Increasing the power of the α-rhythm indicates a decrease in the level of nonspecific cerebral activation and is one of the main characteristics of the state of functional comfort. Statistically significant ifferences in the indices of powers of the β - and β -rhythms inherent in the state of active wakefulness were determined. The decrease1 2in the power index of the electoencephalography delta rhythm was revealed. The revealed dynamics of cerebral blood flow parameters was subject to pronounced individual differences, which made it impossible to determine the direction of the trend. It was established a gradual decrease in the power of the low-frequency component of the cardiorhythm with simultaneous increase in the contribution power of the high-frequency component, reaching a statistically significant difference at the last stage of registration, which leads to a significant decrease in the coefficient of vagosympathetic balance after the audiovisual stimulation session. The revealed changes indicate a decrease in the tone of the sympathetic part of the autonomic nervous system. Thus, it is established that after a single 15-minute audiovisual stimulation session, the value of the α-rhythm power in the frontal, anterior parietal and occipital leads of the right and left hemispheres of the brain increases, the power indices of the beta and delta rhythms of the electoencephalography decrease, the stress index and the vegetative index decrease balance, and also the coefficient of the vagosympathetic balance of the rhythmocardiogram. These changes characterize the optimization of the functional state of the organism and contribute to an accelerated restoration of working capacity.
Features of primary morbidity of military personnel who serve in conditions of occupational hazards
Authors: Grigoryev S G , Zagorodnikov G G , Sanzharevsky V A , Sivashchenko P P
Published: July 2021

The comparative analysis of primary morbidity of officers involved in work with occupational hazards of chemical or radiation nature in 2007-2014 has been performed. It was established that the group of officers involved in work with organophosphorus compounds has significantly higher rate of respiratory system diseases and lower rate of primary morbidity of the circulatory system diseases than the officers involved in work with ionized radiation sources. It was demonstrated that the main contribution to the primary morbidity was made by the following classes: diseases of respiratory system, diseases of musculoskeletal system and connective tissue, diseases of digestive system and diseases of circulatory system. The primary morbidity for leading categories of diseases among military personnel who worked with organophosphorus compounds in two regimes (immediate activities to destroy organophosphorus compounds and support for this process (guard, medical and fire services) did not depend on the nature of work. The rate of respiratory system diseases was relatively higher among all Russian Federation Armed forces servicemen and among those who worked with highly toxic substances (mainly due to acute infections of the upper respiratory tract). For the other classes considered the primary morbidity was higher in the risk groups. Evaluation of the role of specific nosological forms showed that in a group of servicemen working with organophosphorus compounds the rates of acute infections of the upper respiratory tract of multiple and unspecified localization, other nasal and nasal sinuses diseases, dorsalgia predominated but was inferior to the incidence of chronic ischemic heart disease. In this connection it is necessary to elaborate and conduct the preventive measures against above mentioned categories of diseases and main nosological forms of these categories.
Efficiency of lithium salt of disulphide of glutathione and inosine in treatment of multiple sclerosis in experiment
Authors: Antushevich A E , Grebenyuk A N , Apchel V Ya , Katsaluha V V , Korovin A E , Tsygan N V , Klimov A G , Gavrilyuk B L
Published: July 2021

We studied the possibility of pharmacological correction of neurological disorders in guinea pigs and rabbits with the lithium salt of disulphide of glutathione and inosine medication in experimental allergic encephalomyelitis caused by inoculation of the main myelin protein in Freund’s complete adjuvant. The intradermal test with the main protein of myelin was accomplished in all animals to confirm the autoimmune process at 21st day after sensibilization. The lithium salt of disulphide of glutathione and inosine medication was administered intramuscularly every other day at a single dose of 10 mg/kg for 5 weeks. The symptoms of experimental allergic encephalomyelitis were more pronounced in rabbits and to a lesser extent in guinea pigs. The high therapeutic efficacy of lithium salt of disulphide of glutathione and inosine was established according to the severity and incidence of neurological disorders (dysfunction of the pelvic organs, ataxia, tremor, paralysis and paresis of the limbs) and lethality rate. Early (at 5 days after sensibilization) and subsequent therapeutic use of lithium salt of disulphide of glutathione and inosine prevented the development of experimental allergic encephalomyelitis in 75% of laboratory animals, in the rest 25% of the animals the course of experimental allergic encephalomyelitis was comparatively mild. There were no lethal outcomes in study group compared with lethal outcomes in 70% of animals in control group. Experimental evidence of neuroprotective effects of lithium in brain ischemia and in neurodegenerative diseases highlights new opportunities for the use of lithium-containing drugs in clinical neurology. It has been confirmed that the lithium salt of glutathione and inosine disulfide has a moderate immunosuppressive effect, inhibiting the biosynthesis of antibodies and the delayed-type hypersensitivity reaction.
Quality control of batches of bacteriological examination kits «Selective differential-diagnostic medium for recovery of Bacillus anthracis and closely related bacilli of Bacillus cereus group»
Authors: Ryazanova A G , Aksenova L Yu , Zuenco A A , Gridina T M , Buravtseva N P , Eremenko E I
Published: July 2021

Possibilities of quality control of experimental series of a set of reagents for bacteriological studies «Selective differential diagnostic environment for the isolation of the causative agent of anthrax and closely related bacilli of the Bacillus cereus group» is justified. Findings of the investigation of growth properties of the selective medium showed typical colonial morphology of virulent strains of Bacillus anthracis (B. anthracis 81/1, B. anthracis 1(CО), B. anthracis 1193, B. anthracis И-363, B. anthracis 1283) and its vaccine strains B. anthracis CTI-1, B. anthracis Ihtiman, B. anthracis Sterne 34 F2, B. anthracis 55, B. anthracis 71/12 - II Tsenkovsky’s vaccine). The colour of the batches of selective medium and Hottinger’s agar around the Bacillus anthracis colonies was unchanged. Whereas, the colour of selective medium around colonies of closely related saprophytes of genus Bacillus discoloured to bright-yellow, allowing to differentiate colonies of anthracic micro germs and closely related microorganisms. Presence of inhibiting properties of the selective medium was confirmed using heterologous germ cultures (Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Proteus vulgaris HX-19) which showed no growth in all series of the tested medium. Meanwhile, the typical colonial morphology of strains of these microorganisms was observed on Hottinger’s agar.
Possibilities of pharmacological correction of pathologies of gepatobiliarny system
Authors: Musayeva E M , Huseinova G A , Polukhova Sh M , Gasymova S V , Jafarova R E
Published: July 2021

Diseases of the hepatobiliary system increase from year to year. Etiopathogenetic factors of liver lesion development are different, but in all cases of hepatopathies, despite a polietiologichnost of lesions, the treatment of a disease in general is referred on improvement of hepatocytes, and rather close pathogenetic therapy is for this purpose applied. Numerous researches reveal the leading role of an oxidative stress and, provoked by it, the perekisny oxidation of lipids of phospholipid membranes of hepatocytes provoked, by it in development of hepatopathies of any etiology. Taking into account a pathogenesis, of hepatopathies treatment of pathologies assumes an integrated approach. A specific place in the treatment of hepatopathies is held by gepatoprotektor - the means, which rise fastness of hepatocytes to the damaging factors. Today, n medical practice a series of gepatoprotektors of animals, plant and animal origin is used. By present time, are developed and studied a series of drugs of a plant origin, among which, the most often used, and well learned, are drugs of the sum of the flavonoids, received from a spotty thistle. Phytocomplexes for the purpose of their use for treatment and prophylaxis of development of the hepatopathies including caused by use of the medicinal preparations prescribed on vital indicators are framed and are investigated. The review of available literature showed, that despite the sufficient range of hepatoprotective drugs, today, the drugs conforming to clinical requirements no. In this regard search of new and modern highly effective medicines for treatment of the lesions of a liver of various etiology taking into account a development pathogenesis and which aren’t rendering undesirable side effects remains a current problem of medical science and practice. The leading direction is search of these means in group of substances with antioxidatic and antigipoksantny activity.
Regenerative properties of human extraembryonal organs in tissue engineering
Authors: Kalyuzhnaya L I , Kharkevich O N , Schmidt A A , Protasov O V
Published: July 2021

The characteristics of the umbilical cord extracellular matrix are discussed relatively of their potential use for tissue engineering. The purpose of this review is to assess the current knowledge about using of homologous biomaterials with regenerative properties to create bioengineered structures. One of the most important components of tissue engineering - matrix (scaffold), resident cells can migrate, attach to it and function. Due to their structure, matrices should be easily integrated into the patient’s tissue and provide conditions for cell growth and differentiation. The cells that populate the matrix in the bioreactor before the transplantation of this construction, or resident cells recruited into the transplanted extracellular matrix), and cell- matrix interactions are absolutely necessary components of tissue engineering. Available commercial bioengineering products made from mammalian tissues have certain advantages and significant disadvantages due to the risks of immunological reactions and transmission of infectious agents. The transplantation of products from xenogenic materials is prohibited by law in the Russian Federation. The donor material is limited, receipt of human cadaver material requires a long period of legal registration, which has a detrimental effect on the biomaterial. Therefore, finding a suitable homologous biomaterial is ongoing. Due to the peculiarities of the embryonic phenotype, extraembryonic tissues have special biological properties, one of which is the scarless healing of wounds. Low immunogenicity, optimal mechanical properties of extracellular matrix, presence of cell adhesion molecules and growth factors promoting regeneration provide anti-inflammatory, anti-fibrotic, anti- scarring properties for tissue engineering structures from umbilical cord and amniotic membrane. Umbilical cord and amnion due to the availability and non-invasiveness of obtaining from healthy young donors are an excellent source of homologous biomaterial for extracting matrices, cells and hydrogels for tissue engineering and regenerative medicine.
To the 140th anniversary of the legendary Professor of surgery V.F. Voyno-Yasenetsky (Archbishop Luka)
Authors: Morgoshiya T Sh , Apchel V Ya
Published: July 2021

The main milestones of life and professional path of an outstanding surgeon of the 20th century Voyno-Yasenetsky (Archbishop Luka) are considered. In 1915, Voino-Yasenetsky published a book «Regional anesthesia» in Staint Petersburg with his own illustrations, and in 1916 he defended his doctoral dissertation in Moscow University on regional anesthesia: the thesis was awarded the prize of the University of Warsaw. In 1917-1930s he worked in Tashkent - the first doctor-surgeon of the city hospital, and from March 1917 - a chief doctor. Since 1920 Voyno-Yasenetsky became a Professor of topographical anatomy and operative surgery at newly established Turkestan University. Voyno-Yasenetsky made great contributions to practical surgery. In his honor several operation were named: resection of affected by purulent process in the sacroiliac joint, the posterior part of the Ilium (pelvic resection by Voyno-Yasenetsky), operation of excision of the affected skin and fatty tissue of the axillary fossa when multiple hidradenitis (Voyno-Yasenetsky operation), incision in the popliteal fossa, supplementing arthrotomy purulent chase (cut by Voyno- Yasenetsky). Also he worked on other problems of clinical surgery. Voyno-Yasenetsky invented the original closure method of the wound located on the periphery of the diaphragm (Voyno-Yasenetsky method). He proposed a new method of spleen mobilization and ligation of blood vessels during splenectomy (Voyno-Yasenetsky method). He described important for surgeons topographic- anatomical landmarks - the projection of the sciatic nerve on the skin back of thigh (Voyno-Yasenetsky line) and the place of exit of the sciatic nerve under the gluteal folds (Voyno-Yasenetsky point). For the books «Sketches of purulent surgery» (1943) and «Late resections of infected gunshot wounds of the joints» (1944) in 1946 he was awarded the Stalin prize of the first degree. Since 1946, in connection with the illness, he departed from surgical activity and before the end of his life he lived in Simferopol (Crimea).
Review of interactive methods of teaching physics at medical University
Authors: Novikova N G , Pronina N V , Klishkova N V
Published: July 2021

The article is devoted to the analysis of the literature on the methodology of teaching physics in high school in the section on the application of interactive teaching methods. The review of lecture, practical and seminar forms of contact interactive educational activity of students is presented. Specifically, the actual conceptual approach, based on the principles of the methodology of fundamental disciplines to the organization of educational activity of students, as a research partnership of student-tutor, is presented. The conceptual approach is developed in the context of requirements of modern educational standards of formation of students’ professional competencies. By order of the Ministry of education and science of the Russian Federation, the Federal state educational standard of higher education defines research activity as one of the main types of professional activity, to which graduates who have mastered the speciality program in medical specialities are prepared. Graduates who have mastered the program of the specialty, will have to solve professional tasks of a research sector, which are determined by the Federal state educational standard of higher education including, as an analysis of scientific literature and official statistical surveys, participation in statistical analysis and public presentation of the results, participation in solving individual research and scientific-applied problems in the field of health diagnosis, treatment, medical rehabilitation and prevention. Thus, the role of the educational departments of educational institutions, where students study the sections of such fundamental Sciences as physics and mathematics, the methodology of which is scientific research, increases significantly. Realization of the educational potential of the methodology in basic Sciences is available in the professional research tasks in conditions of a new conceptual approach to the organization of training of students in the sections of these Sciences. The format of the prolonged interactive research partnership student-tutor at all stages of educational activity is considered as effective one for the students’ training for the solution
Organization of rendered surgical assistance in extreme conditions of autonomous navigation
Authors: Soroka A K , Kotelnikov V N , Nazarov V E , Geltser B I , Dergunov V A
Published: July 2021

The problem related to the need to improve the effectiveness of providing emergency surgical care in extreme conditions of autonomous navigation is discussed. The principle of organization of medical support cannot be effectively implemented in the realities of the present time, due to the lack of sufficient naval bases. Modern medical technologies seem to be a strategic reserve that can solve the emerging problems before the medical service of the Navy. The most priority and promising technique with a high level of quality of urgent surgical care is the use of laparoscopic techniques by the personnel of the medical service directly at the ship’s medical station. Presented data on the results of the application of this technique indicate its prospects. In addition, in order to optimize the provision of emergency medical care to seamen in conditions of autonomous navigation, it is expedient to actively use telemedicine. The historical and systematic review of modern literature confirms the high potential of these methods provided that the surgeons’ competence and scientific and practical solution of technical aspects are sufficient. Important is the development of professional standards for specialized medical care in emergency conditions in the sea and active implementation in clinical practice.
The contribution of A. Gref to clinical ophthalmology (to the 190th anniversary of the birth)
Authors: Morgoshiia T Sh , Apchel V Ya
Published: July 2021

The first scientific and practices works in ophthalmology of Professor Albreht Grephe are possibilities. Notes, that in 1850 Hermann Helmholtz introduced the ophthalmoscope into clinical practice, this tool allowed Albrecht Gref to make a number of discoveries and scientific proposals concerning the pathology of the fundus. He described the embolism of the retinal artery, differentiated central recurrent syphilitic retinitis from diffuse, described optic neuritis and much more. Seven years of his scientific work, A. Gref has devoted to the study of the functioning of the eye muscles, strabismus and its correction by surgery, the study of amblyopia. Later, he described in detail the symptoms of ocular muscle paralysis and the clinical manifestations of diphtheria and benign renal conjunctivitis, outlined the ways of drug treatment of these diseases. Gref considered eye pressure the main cause of glaucoma. In his opinion, reducing pressure, it was possible to save the patient from glaucoma. During the treatment of the patient with complete infection of the pupil, A. Grefe made iridectomy (excision of the iris part) and noticed that the eye after the operation became softer. This prompted the doctor to think about the possibility of using such an operation for glaucoma. It is important to note that at the first International Ophthalmological Congress in Brussels in 1857 Gref made a report «On the nature and treatment of glaucoma by iridectomy». This operation brought him world fame and saved many glaucoma patients from blindness. Iridectomy is used in ophthalmic practice and at the present time. In 1859 Grefe proposed a method for peripheral linear extraction of cataracts. He made a peripheral linear cut, thanks to which the divergence of the edges of the wound of the patch cut was eliminated. For such a cut Grefe invented a special long and narrow scalpel, behind which the name Grefevsky was preserved. As time has shown, the basic theoretical and practical provisions and discoveries of Grefe still form the foundation of our knowledge in ophthalmology.
History of military hygiene studies in the russian army
Authors: Zholus B I , Petreyev I V
Published: July 2021

The issue of teaching in military schools the discipline «military hygiene» is being considered. The experience of the Russian army shows that from the fourth quarter of the 19th century, and until 1917 military hygiene was an academic discipline in the training of cadets and officers. At the same time, programs and textbooks were created, even for training at the accelerated courses of cadets and officers during the First World War. The textbooks contained sections on the basics of international military law, human anatomy and physiology, food hygiene, water supply, placement of military personnel in stationary and field conditions, hygiene uniforms, bath and laundry services, personal hygiene, rules for maintaining the territory and cleaning battlefields. Separate chapters presented the issues of urgent illnesses for the troops and their prevention. At the same time, comparative statistics are provided on the irrecoverable losses of troops from weapons and mainly from diseases. In addition, the textbooks contained information on the organization of the army’s sanitary service, the rules for the arrangement of premises for the sick and wounded were considered. In the applications, even the «highest approved» Instruction for protecting the health of the military ranks of the active army, various methods and tools for hygienic analysis, methods, disinfectants and others were presented. Here you can find a list of control questions on the sections of the discipline and the answers to them, which indicates the control over the assimilation of the material.
Contribution of Institute of preventive sciences of Z.P. Solovyov of Military Medical Academy to development of military health care
Authors: Voskresensky V V , Kuznetsov S M , Maydan V A , Zaymagov S V , Bokharev M A
Published: July 2021

Here you can find information based on documentary data about the establishment and activities of Z.P. Solovyov`s Institute of Preventive Sciences of Military Medical Academy from 1925 to 1928. The institute was organized to develop hygienic thinking on November 21 1925, and became one of the first foundations of the Soviet Union, which provided training for preventive specialists. In the order №216 signed by the chief of the Head Military and sanitary department and the deputy national commissioner of health care Z.P. Solovyov on November 19, 1925, were defined strategic objectives of creation of institute among which: 1) full coherence and improvement of teaching a cycle of sanitary and preventive disciplines according to requirements of army; 2) educate listeners and doctors in accordance with the basic principles of Soviet medicine, which gives the lead to disease prevention. As the building for new institute, the three-storyed obstetric and gynecologic clinic of the academician G.E. Rein at Mikhaylovsky hospital of the baronet Villiye which was a part of Imperial Military Medical Academy has served. Many departments in the academic institute were united, among which three were prophylactic: Department of Microbiology with epidemiology and disinfection course, Departments of General and Military, Social Hygiene. On the example of educational, research and public work of departments of a hygienic profile of institute the contribution of an educational institution as in the system of training of highly qualified specialists in the health sector, and in the system of health protection of the military personnel reveals. It has been established that studying by a staff of departments of a number of questions on a perspective of preservation and promotion of health of soldiers and officers, has an exclusive character in our country.
DIAGNOSTICCRITERIAANDMANAGMENTOF ACUTE CHOLANGITIS AND BILIARY SEPSIS: THE MODERN VIEW ON THE PROBLEM
Authors: Korolkov A Yu , Popov D N , Kitaeva M A , Tantsev A O
Published: July 2021

Theproblemofcholangitisandbiliarysepsisbecomemoreandmoreactual.Developingdiagnosticcriteriaforpatientswithinflammationofbiliarytractisoneofunsolvedquestionsofbiliarysurgery. Accordingtonewclassificationofgeneralizedformofinfections (Sepsis 3) it’sadvisabletoclassifiedpatients with biliary obstruction to three groups: mechanical jaundice, acute cholangitis and biliary sepsis with defying appropriate diagnostic criteria for each of them.Theaimofourworkistoimprovetreatmentresultsforpatientswithhyperbilirubinemia, biliary hypertension and system inflammation response syndrome (SIRS) by dividing them on groups and determining diagnostic criteria for each of them. Intheperiodfrom 2014 to 2018 wehavetreated 208 patientswithbiliaryobstruction. Accordingtodevelopeddiagnosticcriteriaallpatients was divided on three groups: mechanical jaundice, acute cholangitis and biliary sepsis.Afterthetreatmentthenextvalueswereanalyzed: timefromadmissiontohospitaltooperation, thetimeofoperation, thefrequencyofpostoperativecomplications, mortality, the duration of hospital stay, economic efficiency.Toassesstheeffectivesofdevelopedcriteriacomparativeanalysiswithretrospectivegroup, whichcontained 182 patients with hyperbilirubinemia, biliary hypertension and SIRS treated in a period from 2010 to 2014, was performed. Accordingtoobtainedresultswecanconcludethatdividingpatientswithhyperbilirubinemia, biliary hypertension and SIRS on groups and developeddiagnosticcriteria, routing and manage tactics let us to improve treatment results in this category of patients, about what we can judge by such figures as timefromadmissiontohospitaltooperation, thefrequencyofpostoperativecomplications, mortality, the duration of hospital stay, economic efficiency.
FIBROCHOLODOSCOPY IN DIAGNOSTICS AND TREATMENT OF COMPLEX FORMS OF CHOLEDOCHOLITHIASIS
Authors: Pavelets K V , Ushkats A K , Gacko D V
Published: July 2021

Relevance of the topic: endoscopic intraoperative choledochoscopy with traditional surgical procedures is a highly informative research in the diagnosis and treatment of choledocholithiasis. Objective: to evaluate the effectiveness of intraoperative use of fibrocholedochoscopy in the diagnosis and treatment of "complex" forms of choledocholithiasis. Materials and methods: Between 2011 and 2017, 88 patients underwent treatment for "complicated" forms of choledocholithiasis using intraoperative fibrocholedochoscopy. Results: after dissection of the choledochal wall and extraction of large concrements from the lumen, a fibrocholedochoscopy was performed. The fibrocholedochoscope was inserted into the lumen of the common bile duct through a formed opening with examination of the biliary tract. An obligatory condition for assessing the permeability of the distal sections of the bile ducts was the carrying out of an endoscope through the OBD zone. The remaining remaining calculi were recovered with the help of Dormia baskets (15 (17%) cases). In 86 (97.7%) patients, the operation is completed by the imposition of a hollow stitch of choledoch (priority reference No. 2018122530, 2018). Conclusion: fibrocholedochoscopy in the treatment of complex forms of choledocholithiasis allows to methodically evaluate the biliary tract, perform lithoextraction from the proximal and distal sections.
THE USE OF MESH ENDOPROSTHESIS IN SURGICAL TREATMENT OF VENTRAL HERNIA
Authors: Ragimov V A , Ragimli Sh I
Published: July 2021

Surgical treatment of patients with ventral hernias remains an urgent problem in abdominal surgery. More than 20 million operations are performed annually in the world for hernias. The urgency and complexity of the problem is based on the fact that inadequately performed surgery leads to a recurrence of the disease in 14-54% of cases. The aim of the work is to study the results of surgical treatment of patients with ventral hernias using mesh endoprostheses. The results of a retrospective analysis of 437 hernioplasty performed with hernias of various localizations for the period from 2010 to 2014 were used. Patients were classified by hernia localization and divided into groups depending on the methods of alloplasty. The duration of observation of patients operated by using polypropylene mesh ranged from 6 month to 3 years. An analysis of the complications that developed after alloplasty of the inguinal, postoperative, umbilical hernias and hernias of the linea alba was carried out. Our clinical experience confirms that the operation of Liechtenstein is rightly considered to be the “gold standart” for the treatment of inguinal hernias. However, the use of polypropylene mesh in the treatment of inguinal hernias leads to the development of postsurgical wound complications. Placed next to the polypropylene mesh peritoneum flap plays the role of internal drainage, prevents the development of seromas in the wound. The use of a new inguinal alloplasty technique reduced the number of postoperative complications. Also, the best immediate and long-term results are obtained by alloplasty using a sublay method. In patients with postoperative hernias operated by sublay method, no recurrences were observed and they showed the best quality of life.
The use of high-frequency denervation of the intervertebral joints after surgical treatment of degenerative spinal diseases
Authors: Tyulikov K. V. , Manukovsky V. A. , Spitсуn M. I.
Published: July 2021

The article presents the study results of the effectiveness of intervertebral joints high-frequency denervation as a modern minimally invasive method of pain management after surgical treatment of degenerative diseases of the spine. The degenerative process affects all the structures of the spine as a complex biomechanical system. The defeat of the intervertebral joints degenerative process accompanies the stenosis of the spinal canal, degenerative vertebral prosthesis, herniated protrusion of intervertebral discs, and makes a significant role in the development of pain in the lumbar region. The creation of spondylodesis in the vertebral-motor segment as a result of surgical treatment causes functional changes in adjacent segments in the form of compensatory hypermobility formation. These changes often lead to exacerbation of chronic arthrosis of the intervertebral joints. It was established that minimally invasive electrosurgical techniques proved to be safe and effective methods of treatment of carefully selected patients with pain in the lower back and legs caused by degenerative-dystrophic process. In this case, complications during such procedures are extremely rare. In all operated patients during 3 months of follow-up the severity of pain syndrome on the visual-analog scale was less, and the level of satisfaction of patients with treatment of degenerative- dystrophic diseases of the spine was higher than in patients with subsequent conservative treatment of pain syndrome. The main advantages of the technique are their safety, effectiveness and minimal invasiveness.
Legal regulation of telemedicine in the health care system of the Russian Federation: state and prospects for improvement.
Authors: Allamyarova N V , Sanakoeva E G
Published: July 2021

The legislation in the field of e-health, adopted in 2017, opens fundamentally new opportunities in the development of medical care using telemedicine technologies. The article provides an analysis of regulatory legal documents that establish the legal framework for the provision of medical care using telemedicine technologies. An assessment is made of the current state of telemedicine legal regulation in Russia. The law on telemedicine requires adjustment and refinement of existing regulations, procedures, standards of medical care with a detailed regulation of tools and situations of their application.
Epidemiological aspects of the incidence of acute respiratory viral infection in the village of Poltava in the Krasnoarmeysky district of the Krasnodar Territory in the epidemiological season of 2018–2019
Authors: Umantseva A. M. , Arakelyan R. S. , Adamova D. S.
Published: July 2021

The results of the incidence of acute respiratory viral infection in the village of Poltava in the Krasnoarmeysky district of the Krasnodar Territory in the epidemiological season (December 2018 – March 2019) are presented. There were 120 people under the supervision of 18 to 79 years of age who sought medical help from a local GP in this time range with complaints of fever, weakness, headache, cough, sleep disturbance, sore throat when swallowing, chest pain cage, nasal congestion and hoarseness of voice. All applicants were diagnosed with Acute Respiratory Viral Infection. In all cases, the diagnosis was based on the collection of complaints, anamnesis, physical examination data, a clinical blood test with a white blood cell count and a general urinalysis. It was established that the body temperature of patients with adequately prescribed therapy and the implementation of all the prescribed recommendations lasted from three to five days from the start of treatment, in rare cases up to seven days. The duration of the disease and the number of days of disability during inpatient treatment most often ranged from 10 to 15, with outpatient treatment – 5–10. In rare cases, the duration of the disease and treatment was several days. In the treatment of acute respiratory viral infection, the following drugs were used: Tamiflu, Nomides, Influceil, Ingavirin, Kagocel and Ergoferon.
Hemorrhagic fever with renal syndrome among military personnel in Primorsky Krai
Authors: Iunikhina O V , Kompanets G G , Solovei A L , Rybakova N A , Naduda E A
Published: July 2021

A study was made of the specific features of the incidence of hemorrhagic fever with renal syndrome among military personnel in the territory of Primorsky Krai and the relationship between the manifestations of infection and the epizootic process among natural carriers of hantavirus. It was established that the incidence of this infection from 2001 to 2015 was characterized by a predominance of middle-aged persons, a connection between the severity of the clinical course and infection conditions, a seasonal and long-term distribution of cases and features of the epizootic process among murine rodents - natural carriers of hantavirus. Infection with ortho-hantavirus among military personnel took place both in domestic conditions and in the process of military professional activity. The circumstances of the most frequent occurrence of sporadic and group cases of diseases are revealed.
The incidence of alleles and genotypes of polymorphic genes leptin G(-2548) A, adiponectin G(276) T and receptor adiponectin A(+219) T in patients with psoriasis alimentary obesity
Authors: Rychkova I V , Pritulo O A , Malyi K D
Published: July 2021

Investigated prevalence of alleles and genotypes G(-2548)A (rs7799039) gene leptin and G(276)T (rs1501299) of the adiponectin and A(+219)T (rs11061971) adiponectin receptor 2 in patients with psoriasis with abdominal obesity. The frequency of the allele A of the promoter region of the G(-2548) A polypeptide leptin gene in 99/226 (43,8%) patients with a body mass index ≥30 kg / m2 was found to be higher than in69/228 (30,3% ) patients with a body mass index
Ischemic complications of operations on intracranial aneurysms and their relationship with the dynamics of cognitive functions
Authors: Voytsekhovsky D V , Svistov D V , Zheleznyak I S , Lytkin M V , Savello A V , Babichev K N , Landik S A , Martynov R S , Rudnev A A , Dikikh K A , Polezhaev A V , Bannikov A S
Published: July 2021

Surgical treatment remains the only way to primary prevention of intracranial hemorrhage in patients with cerebral aneurysms. The implementation of such interventions is associated with the risk of the development of secondary cerebral circulation disorders. The effect of ischemic damage to cerebral structures on the state of mental functions and the quality of life of patients is currently not well understood. The interrelation of the formation of foci of cerebral infarction according to magnetic resonance imaging and the dynamics of the state of cognitive functions of patients undergoing surgery for unruptured cerebral aneurysms is considered. It has been established that «fresh» foci of ischemic damage are formed in a third of patients. Among patients operated on with intravascular access, brain infarction zones are formed in half of the patients. Endovascular interventions under balloon assistance are associated with a high risk of asymptomatic ischemic complications. When comparing the results of neuropsychological examination in patients with diagnosed foci of cerebral infarction and the group where the ischemic complications were absent, no significant differences were found. According to the neuropsychological examination, the results before and after the operation did not differ significantly in patients with infarction foci. Thus, after surgery for unruptured aneurysms, local foci of cerebral infarction are often detected. In most cases, these changes are not associated with the deterioration of the higher mental functions of patients and are asymptomatic.
Clinical-hemodynamic efficiency of fixed combined hypotensin therapy for patients with heavy arterial hypertension
Authors: Gizi Azayeva N R
Published: July 2021

The efficacy of treatment was evaluated by the fixed combination drug «Exforge-H» in 40 patients suffering from grade 3 arterial hypertension. All patients underwent general clinical and laboratory and instrumental examination (electrocardiography, echocardiography, 24-hour blood pressure monitoring) before and after 6 months of treatment. It was established that treatment with «Exforge-H» statistically reliably reduces the level of blood pressure, normalizes the variability and daily blood pressure profile. So, two weeks after the start of treatment, the systolic and diastolic pressure levels during clinical measurement decreased by 32,1±2,7 and 30,4±1,9 mm Hg. Art. respectively. After 3 months of treatment, 60% of patients showed achievement of the target level of blood pressure, and after 6 months - 96%. High hypotensive efficacy of treatment was also demonstrated during the daily monitoring of blood pressure in all its indicators. A significant decrease in systolic and diastolic pressure was observed during the day and night hours. The amplitudes of systolic and diastolic pressure variability have also been improved. At the same time, the variability of systolic pressure during the day was reduced by 46%, diastolic - by 49%, and at night by 59,3 and 52,8%, respectively, indicating a normalization of blood pressure during the day. All this was also accompanied by a decrease in the clinical manifestations of the disease. So, after 6 months of treatment, 84% of patients had positive clinical dynamics: a decrease in cardiac and cerebral symptoms, as well as emotional lability, which positively correlated with a decrease in the level of clinical blood pressure. The cardioprotective effect of the drug is expressed in the form of regression of left ventricular hypertrophy. In general, the use of the three-component fixed drug «Exforge-H» (valsartan - 80 mg, amlodipine - 5 mg and hydrochlorothiazide - 12,5 mg) is manifested by an increased antihypertensive effect due to the influence of its constituents side effects and the development of metabolic changes.