bluuebunny/crossref_metadata_2025 huggingface dataset:
Phytochelators Intended for Clinical Use in Iron Overload, Other Diseases of Iron Imbalance and Free Radical Pathology
Authors: Kontoghiorghe Christina , Kolnagou Annita , Kontoghiorghes George
Published: November 2015

Iron chelating drugs are primarily and widely used in the treatment of transfusional iron overload in thalassaemia and similar conditions. Recent in vivo and clinical studies have also shown that chelators, and in particular deferiprone, can be used effectively in many conditions involving free radical damage and pathology including neurodegenerative, renal, hepatic, cardiac conditions and cancer. Many classes of phytochelators (Greek: phyto (φυτό)—plant, chele (χηλή)—claw of the crab) with differing chelating properties, including plant polyphenols resembling chelating drugs, can be developed for clinical use. The phytochelators mimosine and tropolone have been identified to be orally active and effective in animal models for the treatment of iron overload and maltol for the treatment of iron deficiency anaemia. Many critical parameters are required for the development of phytochelators for clinical use including the characterization of the therapeutic targets, ADMET, identification of the therapeutic index and risk/benefit assessment by comparison to existing therapies. Phytochelators can be developed and used as main, alternative or adjuvant therapies including combination therapies with synthetic chelators for synergistic and or complimentary therapeutic effects. The development of phytochelators is a challenging area for the introduction of new pharmaceuticals which can be used in many diseases and also in ageing. The commercial and other considerations for such development have great advantages in comparison to synthetic drugs and could also benefit millions of patients in developing countries.
Cinidium officinale and its Bioactive Compound, Butylidenephthalide, Inhibit Laser-Induced Choroidal Neovascularization in a Rat Model
Authors: Lee Yun , Lee Yu , Kim Jin , Kim Young , Kim Junghyun
Published: November 2015

Choroidal neovascularization (CNV) is a common pathology in age-related macular degeneration. In this study, we evaluated in a rat model the effect of an extract of Cinidium officinale Makino and its bioactive compound, butylidenephthalide, on laser-induced CNV. Experimental CNV was induced in Long-Evans rats by laser photocoagulation. C. officinale extract (COE) and butylidenephthalide was intraperitoneally injected once per day for ten days after laser photocoagulation. Choroidal flat mounts were prepared to measure CNV areas and macrophage infiltration. We used a protein array to evaluate the expression levels of angiogenic factors. The CNV area and macrophage infiltration in COE-treated rats were significantly lower than in vehicle-treated rats. COE decreased the expression levels of IGFBP-1, MCP-1, PAI-1, and VEGF. Additionally, butylidenephthalide also inhibited the laser-induced CNV formation and macrophage infiltration and down-regulated the expression of IGFBP-1, MCP-1 and VEGF. These results suggest that COE exerts anti-angiogenic effects on laser-induced CNV by inhibiting the expression of IGFBP-1, MCP-1, and VEGF, indicating that anti-angiogenic activities of COE may be in part due to its bioactive compound, butylidenephthalide.
Synthesis of Tertiary and Quaternary Amine Derivatives from Wood Resin as Chiral NMR Solvating Agents
Authors: Laaksonen Tiina , Heikkinen Sami , Wähälä Kristiina
Published: November 2015

Chiral tertiary and quaternary amine solvating agents for NMR spectroscopy were synthesized from the wood resin derivative (+)-dehydroabietylamine (2). The resolution of enantiomers of model compounds [Mosher’s acid (3) and its n-Bu4N salt (4)] (guests) by (+)-dehydroabietyl-N,N-dimethylmethanamine (5) and its ten different ammonium salts (hosts) was studied. The best results with 3 were obtained using 5 while with 4 the best enantiomeric resolution was obtained using (+)-dehydroabietyl-N,N-dimethylmethanaminium bis(trifluoromethane-sulfonimide) (6). The compounds 5 and 6 showed a 1:1 complexation behaviour between the host and guest. The capability of 5 and 6 to recognize the enantiomers of various α-substituted carboxylic acids and their n-Bu4N salts in enantiomeric excess (ee) determinations was demonstrated. A modification of the RES-TOCSY NMR pulse sequence is described, allowing the enhancement of enantiomeric discrimination when the resolution of multiplets is insufficient.
New Flavones, a 2-(2-Phenylethyl)-4H-chromen-4-one Derivative, and Anti-Inflammatory Constituents from the Stem Barks of Aquilaria sinensis
Authors: Wang Sin-Ling , Hwang Tsong-Long , Chung Mei-Ing , Sung Ping-Jyun , Shu Chih-Wen , Cheng Ming-Jen , Chen Jih-Jung
Published: November 2015

In the current study, two new flavones, 4′-O-geranyltricin (1) and 3′-O-geranylpolloin (2), and a new 2-(2-phenylethyl)-4H-chromen-4-one derivative, 7-hydroxyl-6-methoxy-2-(2-phenylethyl)chromone (3), have been isolated from the stem barks of A. sinensis, together with 21 known compounds 4–24. The structures of new compounds 1–3 were determined through spectroscopic and MS analyses. Compounds 2, 3, 5, 6, and 8–10 exhibited inhibition (IC50 ≤ 12.51 μM) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB). Compounds 3, 6, 8, 10, and 19 inhibited fMLP/CB-induced elastase release with IC50 values ≤ 15.25 μM. This investigation reveals bioactive isolates (especially 2, 3, 5, 6, 8, 9, 10, and 19) could be further developed as potential candidates for the treatment or prevention of various inflammatory diseases.
Carapanolides T–X from Carapa guianensis (Andiroba) Seeds
Authors: Miyake Teppei , Ishimoto Sari , Ishimatsu Naoko , Higuchi Keiichiro , Minoura Katsuhiko , Kikuchi Takashi , Yamada Takeshi , Muraoka Osamu , Tanaka Reiko
Published: November 2015

Two new mexicanolide-type limonoids, carapanolides T–U (1–2), and three new phragmalin-type limonoids, carapanolides V–X (3–5), were isolated from the seeds of Carapa guianensis (andiroba). Their structures were determined on the basis of 1D- and 2D-NMR spectroscopy.
Electrochemical Characterization of Graphene and MWCNT Screen-Printed Electrodes Modified with AuNPs for Laccase Biosensor Development
Authors: Favero Gabriele , Fusco Giovanni , Mazzei Franco , Tasca Federico , Antiochia Riccarda
Published: November 2015

The aim of this work is to show how the integration of gold nanoparticles (AuNPs) into multi-wall-carbon-nanotubes (MWCNTs) based screen-printed electrodes and into graphene-based screen-printed electrodes (GPHs) could represent a potential way to further enhance the electrochemical properties of those electrodes based on nanoparticles. Laccase from Trametes versicolor (TvL) was immobilized over MWCNTs and GPH previously modified with AuNPs (of 5 and 10 nm). The characterization of the modified electrode surface has been carried out by cyclic voltammetry. The results showed that the use of AuNPs for modification of both graphene and MWCNTs screen-printed electrode surfaces would increase the electrochemical performances of the electrodes. MWCNTs showed better results than GPH in terms of higher electroactive area formation after modification with AuNPs. The two modified nanostructured electrodes were successively proven to efficiently immobilize the TvL; the electrochemical sensing properties of the GPH- and MWCNT-based AuNPs-TvL biosensors were investigated by choosing 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic-acid diammonium salt (ABTS), catechol and caffeic acid as laccase mediators; and the kinetic parameters of the laccase biosensor were carefully evaluated.
miRNA–mRNA Conflux Regulating Immunity and Oxidative Stress Pathways in the Midgut of Blood-Fed Anopheles stephensi
Authors: Jain Shanu , Shrinet Jatin , Tridibes Adak , Bhatnagar Raj , Sunil Sujatha
Published: November 2015

Blood feeding in Anopheles stephensi initiates a cascade of events that modulate several physiological functions in the mosquito. The midgut epithelium activates several of its molecules, most important among these being microRNAs, which regulate some of the physiological changes by targeting diverse mRNAs. The present study was conducted to identify and evaluate interactions between targets of eight miRNAs that are regulated on blood feeding. Identified from our previous study, we show these eight miRNAs exhibited distinct tissue specific expression. Targets of these miRNAs were predicted using computational approaches involving bioinformatics, co-expression analysis of the transcriptome and miRNome of blood-fed An. stephensi midgut. Using degradome sequencing, we identified some cleaved mRNAs of these microRNAs and, by using antagomiR knockdown technology to repress the miRNAs, the targets were validated in an An. stephensi cell line and in An. stephensi mosquitoes. In-depth analysis of predicted and identified targets revealed that the regulated miRNAs modulate well-characterized molecules that are involved in combating oxidative stress and immunity pathways through a dynamic miRNA:mRNA network. Our study is the first to identify miRNA:mRNA interactomes that play important role in maintaining redox homeostasis during blood feeding in the midgut of An. stephensi.
Cognitive Performance and Mood Following Ingestion of a Theacrine-Containing Dietary Supplement, Caffeine, or Placebo by Young Men and Women
Authors: Kuhman Daniel , Joyner Keanan , Bloomer Richard
Published: November 2015

Theacrine is a purine alkaloid found primarily in the leaves of the Camellia Kucha plant and is now included within dietary supplements. To compare the effects of a theacrine-containing dietary supplement with caffeine and placebo on energy and mood, as well as objective measures of cognitive performance, heart rate, and blood pressure, 10 healthy men (20.8 ± 0.7 years) and 10 healthy women (22.2 ± 1.1 years) ingested the dietary supplement TheaTrim (Purus Labs; containing a branded form of theacrine (Teacrine™) and caffeine (150 mg)), caffeine only (150 mg), or a placebo on three different days, separated by approximately one week. Before, and for up to 4 h following, ingestion of the assigned condition, subjects completed a subjective assessment of energy and mood, as well as tests of cognitive performance (trail making test (TMT), digit symbol substitution test (DSST)), and reaction time. Heart rate and blood pressure were measured. No condition or interaction effects were noted for TMT, DSST, or reaction time, despite a trend for improvement in selected variables with both TheaTrim and caffeine treatment. Condition effects or trends were noted for subjective feelings, with values for attentive, alert, focused, and energetic higher for TheaTrim than for placebo and caffeine, while values for lethargic and groggy were lower for TheaTrim than for placebo and caffeine. Heart rate and blood pressure were largely unaffected by treatment. These data indicate that TheaTrim treatment does not result in a statistically significant improvement in cognitive performance but may favorably impact multiple subjective feelings related to energy and mood.
Inconsistency of Association between Coffee Consumption and Cognitive Function in Adults and Elderly in a Cross-Sectional Study (ELSA-Brasil)
Authors: Araújo Larissa , Giatti Luana , Reis Rodrigo , Goulart Alessandra , Schmidt Maria , Duncan Bruce , Ikram Mohammad , Barreto Sandhi
Published: November 2015

Background: Coffee is one of the most consumed beverages worldwide and the effect on cognition appears to be task specific and vary by age. Method: In cohort of 14,563 public service workers (35–74 years old) we assessed coffee consumption habits and examined cognitive function using standardized neuropsychological test battery. By linear regression and generalize linear regression with logarithmic link and gamma distribution we investigated the relation of coffee consumption (never/almost never, ≤1 cup/day, 2–3 cups/day, ≥3 cups/day) in the last 12 months to performance on specific domains of cognition for adults and elderly separately. Results: Among elderly, after adjustments, coffee consumption was associated only with an increase in the mean words remembered on learning, recall, and word recognition tests when comparing the 2–3 cups/day to never/almost never category (arithmetic mean ratio (AMR): 1.03; 95% Confidence Interval (CI): 1.00 to 1.07), and to an increase in the mean words pronounced in semantic verbal fluency test when comparing the ≥3 cups/day to never/almost never category (difference of the mean: 1.23; 95% CI: 0.16 to 2.29). However, coffee consumption was not associated with any cognitive function tests in adults and also was not associated with the phonemic verbal fluency test and trail-making test B in elderly. Conclusions: Results suggest that coffee consumption might be slightly beneficial to memory in elderly but lacks a dose response relationship. Longitudinal analyses are needed to investigate possible, even if subtle, positive effects of coffee drinking on specific cognitive domains in elderly.
Intakes of Calcium and Phosphorus and Calculated Calcium-to-Phosphorus Ratios of Older Adults: NHANES 2005–2006 Data
Authors: Adatorwovor Reuben , Roggenkamp Kathy , Anderson John
Published: November 2015

Background: High intakes of dietary phosphorus (P), relative to calcium (Ca) intake, are associated with a lower calcium:phosphorus ratio (Ca:P) ratio which potentially has adverse health effects, including arterial calcification, bone loss, and death. A substantial percentage of older adults (50 to 70 and 71 plus years) who have a higher risk of fracture rate than younger adults typically have low intakes of dietary Ca that are dominated by higher intakes of dietary P from natural and fortified foods, and lower Ca:P ratios than desirable. Objective: This investigation was undertaken to examine Ca and P intakes and the resulting Ca:P ratios (by mass) across gender and older adult age groups, using data from the National Health and Nutrition Examination Survey (NHANES) 2005–2006. Design: NHANES data are based on a cross-sectional sample of the non-institutionalized United States (US) population within various regions. This sample is selected to be representative of the entire US population at all ages. National Cancer Institute (NCI) methods and SAS survey procedures were used for analyses. Ca:P ratios were calculated using total Ca from both foods and supplements, whereas P intakes were calculated from food composition values and supplements. The amounts of P additives in processed foods are not available. Results: Mean Ca and P intakes demonstrated lower intakes of Ca and higher intakes of P compared to current Recommended Dietary Allowances (RDAs). The Ca:P ratios in older male and female adults were influenced by both low-Ca and high-P dietary consumption patterns. Conclusions: Both low total Ca intakes and high P amounts contribute to lower Ca:P ratios, i.e., ~0.7:1.0, in the consumption patterns of older adults than is recommended by the RDAs, i.e., ~1.5:1.0. Whether Ca:P ratios lower than recommended contribute to increased risk of bone loss, arterial calcification, and all-cause mortality cannot be inferred from these data. Additional amounts of chemical P additives in the food supply may actually reduce even further the Ca:P ratios of older adults of both genders, but, without P additive data from the food industry, calculation of more precise ratios from NHANES 2005–2006 data is not possible.
Virtuality and Reality—Toward a Representation Ontology
Authors: Ropolyi László
Published: November 2015

Based on a brief overview of the history of ontology and on some philosophical problems of virtual reality, a new approach to virtuality is proposed. To characterize the representational (information, cognitive, cultural, communication) technologies in the Internet age, I suggest that Aristotle’s dualistic ontological system (which distinguishes between actual and potential being) be complemented with a third form of being: virtuality. In the virtual form of being actuality and potentiality are inseparably intertwined. Virtuality is potentiality considered together with its actualization. In this view, virtuality is reality with a measure, a reality which has no absolute character, but which has a relative nature. This situation can remind us the emergence of probability in the 17th century: then the concept of certainty, now the concept of reality is reconsidered and relativized. Currently, in the descriptions of the world created by representational technologies, there are two coherent worldviews with different ontologies: the world is inhabited by (absolute) actual and (absolute) potential beings—or all the beings in the world are virtual.
Transient Response of Organo-Metal-Halide Solar Cells Analyzed by Time-Resolved Current-Voltage Measurements
Authors: Christoforo M. , Hoke Eric , McGehee Michael , Unger Eva
Published: November 2015

The determination of the power conversion efficiency of solar cells based on organo-metal-halides is subject to an ongoing debate. As solar cell devices may exhibit very slow transient response, current-voltage scans in different directions may not be congruent, which is an effect often referred to as hysteresis. We here discuss time-resolved current-voltage measurements as a means to evaluate appropriate delay times (voltage settling times) to be used in current-voltage measurements of solar cells. Furthermore, this method allows the analysis of transient current response to extract time constants that can be used to compare characteristic differences between devices of varying architecture types, selective contacts and changes in devices due to storage or degradation conditions.
Socio-Economic Considerations of Converting Food Waste into Biogas on a Household Level in Indonesia: The Case of the City of Bandung
Authors: Amir Encep , Hophmayer-Tokich Sharon , Kurnani Tubagus
Published: November 2015

Household waste is a serious environmental problem in Indonesia, especially in urban areas. Since 2010, biogas production from food waste has been introduced to reduce waste and provided an alternative to liquid petroleum gas (LPG) as cooking fuel in a pilot project in Bandung. Although the produced biogas is sufficient, the socio-economic aspects can hinder application. This study assesses the socio-economic feasibility of the project in Cibangkong, a typical urban area in Bandung, which includes four bio-digesters. The results show that the conversion of food waste into biogas is currently not economically feasible, mainly due to the low penetration of bio-slurry—a by-product commonly used for fertilizer—into local fertilizer supply-chains. From a social perspective, community acceptance is mainly influenced by procedural justice. Furthermore, while the produced biogas is perceived to be quite useful in substituting LPG, it has not yet been fully utilized due to low bio gas pressure and several technical failures, which in turn influence community acceptance of the digesters. It is thus concluded that introducing biogas production from waste to improve waste management and reduce LPG consumption can be feasible when efforts to support the market uptake of bio-slurry, enhance biogas utilization, and improve procedural justice performance, are taken.
Towards an Interoperable Field Spectroscopy Metadata Standard with Extended Support for Marine Specific Applications
Authors: Rasaiah Barbara , Bellman Chris , Jones Simon. , Malthus Tim , Roelfsema Chris
Published: November 2015

This paper presents an approach to developing robust metadata standards for specific applications that serves to ensure a high level of reliability and interoperability for a spectroscopy dataset. The challenges of designing a metadata standard that meets the unique requirements of specific user communities are examined, including in situ measurement of reflectance underwater, using coral as a case in point. Metadata schema mappings from seven existing metadata standards demonstrate that they consistently fail to meet the needs of field spectroscopy scientists for general and specific applications (μ = 22%, σ = 32% conformance with the core metadata requirements and μ = 19%, σ = 18% for the special case of a benthic (e.g., coral) reflectance metadataset). Issues such as field measurement methods, instrument calibration, and data representativeness for marine field spectroscopy campaigns are investigated within the context of submerged benthic measurements. The implication of semantics and syntax for a robust and flexible metadata standard are also considered. A hybrid standard that serves as a “best of breed” incorporating useful modules and parameters within the standards is proposed. This paper is Part 3 in a series of papers in this journal, examining the issues central to a metadata standard for field spectroscopy datasets. The results presented in this paper are an important step towards field spectroscopy metadata standards that address the specific needs of field spectroscopy data stakeholders while facilitating dataset documentation, quality assurance, discoverability and data exchange within large-scale information sharing platforms.
A Refractive Index Sensor Based on a Metal-Insulator-Metal Waveguide-Coupled Ring Resonator
Authors: Yan Shu-Bin , Luo Liang , Xue Chen-Yang , Zhang Zhi-Dong
Published: November 2015

A refractive index sensor composed of two straight metal-insulator-metal waveguides and a ring resonator is presented. One end of each straight waveguide is sealed and the other end acts as port. The transmission spectrum and magnetic field distribution of this sensor structure are simulated using finite-difference time-domain method (FDTD). The results show that an asymmetric line shape is observed in the transmission spectrum, and that the transmission spectrum shows a filter-like behavior. The quality factor and sensitivity are taken to characterize its sensing performance and filter properties. How structural parameters affect the sensing performance and filter properties is also studied.
An Inductorless Self-Controlled Rectifier for Piezoelectric Energy Harvesting
Authors: Lu Shaohua , Boussaid Farid
Published: November 2015

This paper presents a high-efficiency inductorless self-controlled rectifier for piezoelectric energy harvesting. High efficiency is achieved by discharging the piezoelectric device (PD) capacitance each time the current produced by the PD changes polarity. This is achieved automatically without the use of delay lines, thereby making the proposed circuit compatible with any type of PD. In addition, the proposed rectifier alleviates the need for an inductor, making it suitable for on-chip integration. Reported experimental results show that the proposed rectifier can harvest up to 3.9 times more energy than a full wave bridge rectifier.
An Analytic Model for the Success Rate of a Robotic Actuator System in Hitting Random Targets
Authors: Bradley Stuart
Published: November 2015

Autonomous robotic systems are increasingly being used in a wide range of applications such as precision agriculture, medicine, and the military. These systems have common features which often includes an action by an “actuator” interacting with a target. While simulations and measurements exist for the success rate of hitting targets by some systems, there is a dearth of analytic models which can give insight into, and guidance on optimization, of new robotic systems. The present paper develops a simple model for estimation of the success rate for hitting random targets from a moving platform. The model has two main dimensionless parameters: the ratio of actuator spacing to target diameter; and the ratio of platform distance moved (between actuator “firings”) to the target diameter. It is found that regions of parameter space having specified high success are described by simple equations, providing guidance on design. The role of a “cost function” is introduced which, when minimized, provides optimization of design, operating, and risk mitigation costs.
Detection of Lettuce Discoloration Using Hyperspectral Reflectance Imaging
Authors: Mo Changyeun , Kim Giyoung , Lim Jongguk , Kim Moon , Cho Hyunjeong , Cho Byoung-Kwan
Published: November 2015

Rapid visible/near-infrared (VNIR) hyperspectral imaging methods, employing both a single waveband algorithm and multi-spectral algorithms, were developed in order to discrimination between sound and discolored lettuce. Reflectance spectra for sound and discolored lettuce surfaces were extracted from hyperspectral reflectance images obtained in the 400–1000 nm wavelength range. The optimal wavebands for discriminating between discolored and sound lettuce surfaces were determined using one-way analysis of variance. Multi-spectral imaging algorithms developed using ratio and subtraction functions resulted in enhanced classification accuracy of above 99.9% for discolored and sound areas on both adaxial and abaxial lettuce surfaces. Ratio imaging (RI) and subtraction imaging (SI) algorithms at wavelengths of 552/701 nm and 557–701 nm, respectively, exhibited better classification performances compared to results obtained for all possible two-waveband combinations. These results suggest that hyperspectral reflectance imaging techniques can potentially be used to discriminate between discolored and sound fresh-cut lettuce.
Automated Negotiation for Resource Assignment in Wireless Surveillance Sensor Networks
Authors: De la Hoz Enrique , Gimenez-Guzman Jose , Marsa-Maestre Ivan , Orden David
Published: November 2015

Due to the low cost of CMOS IP-based cameras, wireless surveillance sensor networks have emerged as a new application of sensor networks able to monitor public or private areas or even country borders. Since these networks are bandwidth intensive and the radioelectric spectrum is limited, especially in unlicensed bands, it is mandatory to assign frequency channels in a smart manner. In this work, we propose the application of automated negotiation techniques for frequency assignment. Results show that these techniques are very suitable for the problem, being able to obtain the best solutions among the techniques with which we have compared them.
Automated Low-Cost Smartphone-Based Lateral Flow Saliva Test Reader for Drugs-of-Abuse Detection
Authors: Carrio Adrian , Sampedro Carlos , Sanchez-Lopez Jose , Pimienta Miguel , Campoy Pascual
Published: November 2015

Lateral flow assay tests are nowadays becoming powerful, low-cost diagnostic tools. Obtaining a result is usually subject to visual interpretation of colored areas on the test by a human operator, introducing subjectivity and the possibility of errors in the extraction of the results. While automated test readers providing a result-consistent solution are widely available, they usually lack portability. In this paper, we present a smartphone-based automated reader for drug-of-abuse lateral flow assay tests, consisting of an inexpensive light box and a smartphone device. Test images captured with the smartphone camera are processed in the device using computer vision and machine learning techniques to perform automatic extraction of the results. A deep validation of the system has been carried out showing the high accuracy of the system. The proposed approach, applicable to any line-based or color-based lateral flow test in the market, effectively reduces the manufacturing costs of the reader and makes it portable and massively available while providing accurate, reliable results.
Particle Fabrication Using Inkjet Printing onto Hydrophobic Surfaces for Optimization and Calibration of Trace Contraband Detection Sensors
Authors: Gillen Greg , Najarro Marcela , Wight Scott , Walker Marlon , Verkouteren Jennifer , Windsor Eric , Barr Tim , Staymates Matthew , Urbas Aaron
Published: November 2015

A method has been developed to fabricate patterned arrays of micrometer-sized monodisperse solid particles of ammonium nitrate on hydrophobic silicon surfaces using inkjet printing. The method relies on dispensing one or more microdrops of a concentrated aqueous ammonium nitrate solution from a drop-on-demand (DOD) inkjet printer at specific locations on a silicon substrate rendered hydrophobic by a perfluorodecytrichlorosilane monolayer coating. The deposited liquid droplets form into the shape of a spherical shaped cap; during the evaporation process, a deposited liquid droplet maintains this geometry until it forms a solid micrometer sized particle. Arrays of solid particles are obtained by sequential translation of the printer stage. The use of DOD inkjet printing for fabrication of discrete particle arrays allows for precise control of particle characteristics (mass, diameter and height), as well as the particle number and spatial distribution on the substrate. The final mass of an individual particle is precisely determined by using gravimetric measurement of the average mass of solution ejected per microdrop. The primary application of this method is fabrication of test materials for the evaluation of spatially-resolved optical and mass spectrometry based sensors used for detecting particle residues of contraband materials, such as explosives or narcotics.
Study and Test of a New Bundle-Structure Riser Stress Monitoring Sensor Based on FBG
Authors: Xu Jian , Yang Dexing , Qin Chuan , Jiang Yajun , Sheng Leixiang , Jia Xiangyun , Bai Yang , Shen Xiaohong , Wang Haiyan , Deng Xin , Xu Liangbin , Jiang Shiquan
Published: November 2015

To meet the requirements of riser safety monitoring in offshore oil fields, a new Fiber Bragg Grating (FBG)-based bundle-structure riser stress monitoring sensor has been developed. In cooperation with many departments, a 49-day marine test in water depths of 1365 m and 1252 m was completed on the “HYSY-981” ocean oil drilling platform. No welding and pasting were used when the sensor was installed on risers. Therefore, the installation is convenient, reliable and harmless to risers. The continuous, reasonable, time-consistent data obtained indicates that the sensor worked normally under water. In all detailed working conditions, the test results show that the sensor can do well in reflecting stresses and bending moments both in and in magnitude. The measured maximum stress is 132.7 MPa, which is below the allowable stress. In drilling and testing conditions, the average riser stress was 86.6 MPa, which is within the range of the China National Offshore Oil Corporation (CNOOC) mechanical simulation results.
Tunable Microfluidic Devices for Hydrodynamic Fractionation of Cells and Beads: A Review
Authors: Alvankarian Jafar , Majlis Burhanuddin
Published: November 2015

The adjustable microfluidic devices that have been developed for hydrodynamic-based fractionation of beads and cells are important for fast performance tunability through interaction of mechanical properties of particles in fluid flow and mechanically flexible microstructures. In this review, the research works reported on fabrication and testing of the tunable elastomeric microfluidic devices for applications such as separation, filtration, isolation, and trapping of single or bulk of microbeads or cells are discussed. Such microfluidic systems for rapid performance alteration are classified in two groups of bulk deformation of microdevices using external mechanical forces, and local deformation of microstructures using flexible membrane by pneumatic pressure. The main advantage of membrane-based tunable systems has been addressed to be the high capability of integration with other microdevice components. The stretchable devices based on bulk deformation of microstructures have in common advantage of simplicity in design and fabrication process.
SSL: Signal Similarity-Based Localization for Ocean Sensor Networks
Authors: Chen Pengpeng , Ma Honglu , Gao Shouwan , Huang Yan
Published: November 2015

Nowadays, wireless sensor networks are often deployed on the sea surface for ocean scientific monitoring. One of the important challenges is to localize the nodes’ positions. Existing localization schemes can be roughly divided into two types: range-based and range-free. The range-based localization approaches heavily depend on extra hardware capabilities, while range-free ones often suffer from poor accuracy and low scalability, far from the practical ocean monitoring applications. In response to the above limitations, this paper proposes a novel signal similarity-based localization (SSL) technology, which localizes the nodes’ positions by fully utilizing the similarity of received signal strength and the open-air characteristics of the sea surface. In the localization process, we first estimate the relative distance between neighboring nodes through comparing the similarity of received signal strength and then calculate the relative distance for non-neighboring nodes with the shortest path algorithm. After that, the nodes’ relative relation map of the whole network can be obtained. Given at least three anchors, the physical locations of nodes can be finally determined based on the multi-dimensional scaling (MDS) technology. The design is evaluated by two types of ocean experiments: a zonal network and a non-regular network using 28 nodes. Results show that the proposed design improves the localization accuracy compared to typical connectivity-based approaches and also confirm its effectiveness for large-scale ocean sensor networks.
A Modified Rife Algorithm for Off-Grid DOA Estimation Based on Sparse Representations
Authors: Chen Tao , Wu Huanxin , Guo Limin , Liu Lutao
Published: November 2015

In this paper we address the problem of off-grid direction of arrival (DOA) estimation based on sparse representations in the situation of multiple measurement vectors (MMV). A novel sparse DOA estimation method which changes MMV problem to SMV is proposed. This method uses sparse representations based on weighted eigenvectors (SRBWEV) to deal with the MMV problem. MMV problem can be changed to single measurement vector (SMV) problem by using the linear combination of eigenvectors of array covariance matrix in signal subspace as a new SMV for sparse solution calculation. So the complexity of this proposed algorithm is smaller than other DOA estimation algorithms of MMV. Meanwhile, it can overcome the limitation of the conventional sparsity-based DOA estimation approaches that the unknown directions belong to a predefined discrete angular grid, so it can further improve the DOA estimation accuracy. The modified Rife algorithm for DOA estimation (MRife-DOA) is simulated based on SRBWEV algorithm. In this proposed algorithm, the largest and sub-largest inner products between the measurement vector or its residual and the atoms in the dictionary are utilized to further modify DOA estimation according to the principle of Rife algorithm and the basic idea of coarse-to-fine estimation. Finally, simulation experiments show that the proposed algorithm is effective and can reduce the DOA estimation error caused by grid effect with lower complexity.
Dead Spaces, Living Architecture and the Functionality of Death in Post-Conflict Settings
Authors: El Richani Diana
Published: November 2015

Death has the ability to influence an architectural site in such a way that it defines its identity. Bullet holes, political graffiti, and scarred buildings are evidence of past events that have involved death and continue to do so. However, recognizing death through these sites allows post-conflict nations a chance to construct a narrative that was once hidden away. These sites allow death to function in a positive manner—if amnesia-driven urban development projects do not erase them first, that is.
Who Wants to Live Forever? Living, Dying and Grieving in Our Digital Society
Authors: Bassett Debra
Published: November 2015

Almost ubiquitous hardware technology, such as smart phones, ensures that social networking sites are part of users’ everyday norms and routines. However, some are now using these new communication technologies to deal with the issues of death, dying and grief. With the hope of being able to create digital memories to leave behind for future generations, the opportunity to “live on” and become digitally immortal is seen as empowering to some: but what about those left behind? Through a review of the current literature exploring how social media are being used as a new space to grieve and mourn, this paper contributes to the literature by arguing for the need for clarity in the lexicon being used by thanatologists and other disciplines. Furthermore, it introduces the term “digital zombie” to describe the dead who remain “alive” in our digital society. The paper concludes by joining the call for further research into the nascent phenomena being generated by human-computer interaction.
Evaluation of Biomass Yield and Water Treatment in Two Aquaponic Systems Using the Dynamic Root Floating Technique (DRF)
Authors: Silva Laura , Gasca-Leyva Eucario , Escalante Edgardo , Fitzsimmons Kevin , Lozano David
Published: November 2015

The experiment evaluates the food production and water treatment of TAN, NO2−–N, NO3−–N, and PO43− in two aquaponics systems using the dynamic root floating technique (DRF). A separate recirculation aquaculture system (RAS) was used as a control. The fish cultured was Nile tilapia (Oreochromis niloticus). The hydroponic culture in one treatment (PAK) was pak choy (Brassica chinensis,) and in the other (COR) coriander (Coriandrum sativum). Initial and final weights were determined for the fish culture. Final edible fresh weight was determined for the hydroponic plant culture. TAN, NO2−–N, NO3−–N, and PO43− were measured in fish culture and hydroponic culture once a week at two times, morning (9:00 a.m.) and afternoon (3:00 p.m.). The fish biomass production was not different in any treatment (p > 0.05) and the total plant yield was greater (p < 0.05) in PAK than in COR. For the hydroponic culture in the a.m., the PO43− was lower (p < 0.05) in the PAK treatment than in COR, and in the p.m. NO3−–N and PO43− were lower (p < 0.05) in PAK than in COR. The PAK treatment demonstrated higher food production and water treatment efficiency than the other two treatments.
Sustainability in Fashion Business Operations
Authors: Choi Tsan-Ming , Li Yongjian
Published: November 2015

Under the global trend of sustainability, many companies selling fashion products have to reshape their operational strategies. Over the past few years, we have witnessed many fashion companies going green by re-engineering their business processes and establishing their formal sustainability programs. Many important topics, such as closed-loop supply chain management, corporate social responsibility, and economic sustainability, are all related to sustainable fashion business operations management. This paper provides a brief review of these critical topics, introduces the special issue, and proposes future research areas to achieve sustainable operations management in the fashion business.
Eco-Efficiency Trends and Decoupling Analysis of Environmental Pressures in Tianjin, China
Authors: Wang Zhe , Zhao Lin , Mao Guozhu , Wu Ben
Published: November 2015

This study analyzes Tianjin’s eco-efficiency trends during the period 2001–2013 and reasons for their changes, with the aim of contributing to efforts to ensure the city’s sustainable development. While eco-efficiency of all of the indicators that we analyzed showed improvements during the study period, a gap remained in comparison to the more advanced eco-efficiency observed both domestically and internationally. We subsequently introduced decoupling indices to examine the decoupling relationship between environmental pressure and economic growth. This analysis demonstrated that some progress occurred during the study period resulting from the implementation of existing policies and measures entailing resource conservation and reduction in the emission of pollutants. The latter applied, especially, to sulfur dioxide (SO2) and chemical oxygen demand (COD), which both retained strong decoupling states from 2006 to 2013. Other indicators showed an apparent tendency toward decoupling, but most displayed weak decoupling. These findings indicate that further efforts are urgently required to promote strong decoupling. At the end of the twelfth Five-Year Plan period, Tianjin should consider formulating policies from the perspectives of resource consumption and pollutant emissions reduction to promote further sustainable development.
Expanding Red Clover (Trifolium pratense) Usage in the Corn–Soy–Wheat Rotation
Authors: Wyngaarden Sara , Gaudin Amélie , Deen William , Martin Ralph
Published: November 2015

A common agronomic recommendation is under-seeding red clover to wheat in the corn–soy–wheat rotation. As a leguminous cover crop, red clover boosts agro-ecological resilience and productivity through nitrogen fixation, as well as non-nitrogen-related contributions, such as soil temperature and moisture regulation; reduction of erosion, runoff, and leaching; weed suppression; and interruption of pest and disease cycles. The objective of this paper is to propose a system that extends red clover usage into the corn phase of the corn–soy–wheat rotation as a living mulch. The system incorporates strip-tillage, strip-mowing, as well as banded herbicide and fertilizer application in order to maximize productivity and minimize competition. We analyzed the feasibility of this proposal by examining red clover’s adequacy for the proposed system in comparison with other broadleaf, leguminous cover crops, and assessed potential agro-ecological benefits. We considered logistical components of the proposition, including the use of strip-tillage, the application of precision technology, as well as the opportunity for further technological developments. We found that the proposed system has potential to increase agro-ecological sustainability, resilience, and the overall productivity of this three-year rotation. Thus, this easily-implemented practice should be formally studied.
Out of the Dark: Establishing a Large-Scale Field Experiment to Assess the Effects of Artificial Light at Night on Species and Food Webs
Authors: Holzhauer Stephanie , Franke Steffen , Kyba Christopher , Manfrin Alessandro , Klenke Reinhard , Voigt Christian , Lewanzik Daniel , Oehlert Martin , Monaghan Michael , Schneider Sebastian , Heller Stefan , Kuechly Helga , Brüning Anika , Honnen Ann-Christin , Hölker Franz
Published: November 2015

Artificial light at night (ALAN) is one of the most obvious hallmarks of human presence in an ecosystem. The rapidly increasing use of artificial light has fundamentally transformed nightscapes throughout most of the globe, although little is known about how ALAN impacts the biodiversity and food webs of illuminated ecosystems. We developed a large-scale experimental infrastructure to study the effects of ALAN on a light-naïve, natural riparian (i.e., terrestrial-aquatic) ecosystem. Twelve street lights (20 m apart) arranged in three rows parallel to an agricultural drainage ditch were installed on each of two sites located in a grassland ecosystem in northern Germany. A range of biotic, abiotic, and photometric data are collected regularly to study the short- and long-term effects of ALAN on behavior, species interactions, physiology, and species composition of communities. Here we describe the infrastructure setup and data collection methods, and characterize the study area including photometric measurements. None of the measured parameters differed significantly between sites in the period before illumination. Results of one short-term experiment, carried out with one site illuminated and the other acting as a control, demonstrate the attraction of ALAN by the immense and immediate increase of insect catches at the lit street lights. The experimental setup provides a unique platform for carrying out interdisciplinary research on sustainable lighting.
Carbon Footprint Analysis for Mechanization of Maize Production Based on Life Cycle Assessment: A Case Study in Jilin Province, China
Authors: Wang Haina , Yang Yingsheng , Zhang Xiaoyi , Tian Guangdong
Published: November 2015

The theory on the carbon footprint of agriculture can systematically evaluate the carbon emissions caused by artificial factors from the agricultural production process, which is the theoretical basis for constructing low-carbon agriculture and has important guiding significance for realizing low-carbon agriculture. Based on farm production survey data from Jilin Province in 2014, this paper aims to obtain a clear understanding of the carbon footprint of maize production through the following method: (1) one ton of maize production was evaluated systematically by using the Life Cycle Assessment (LCA); (2) the carbon emissions of the whole system were estimated based on field measurement data, (3) using the emission factors we estimated Jilin’s carbon footprint for the period 2006–2013, and forecasted it for the period from 2014 to 2020 using the grey system model GM (1, 1).
Intergenerational Effect of Early Life Exposure to Permethrin: Changes in Global DNA Methylation and in Nurr1 Gene Expression
Authors: Bordoni Laura , Nasuti Cinzia , Mirto Maria , Caradonna Fabio , Gabbianelli Rosita
Published: November 2015

Environmental exposure to pesticides during the early stages of development represents an important risk factor for the onset of neurodegenerative diseases in adult age. Neonatal exposure to Permethrin (PERM), a member of the family of synthetic pyrethroids, can induce a Parkinson-like disease and cause some alterations in striatum of rats, involving both genetic and epigenetic pathways. Through gene expression analysis and global DNA methylation assessment in both PERM-treated parents and their untreated offspring, we investigated on the prospective intergenerational effect of this pesticide. Thirty-three percent of progeny presents the same Nurr1 alteration as rats exposed to permethrin in early life. A decrease in global genome-wide DNA methylation was measured in mothers exposed in early life to permethrin as well as in their offspring, whereas untreated rats have a hypermethylated genomic DNA. Further studies are however needed to elucidate the molecular mechanisms, but, despite this, an intergenerational PERM-induced damage on progenies has been identified for the first time.
Neurotropic Enterovirus Infections in the Central Nervous System
Authors: Huang Hsing-I , Shih Shin-Ru
Published: November 2015

Enteroviruses are a group of positive-sense single stranded viruses that belong to the Picornaviridae family. Most enteroviruses infect humans from the gastrointestinal tract and cause mild symptoms. However, several enteroviruses can invade the central nervous system (CNS) and result in various neurological symptoms that are correlated to mortality associated with enteroviral infections. In recent years, large outbreaks of enteroviruses occurred worldwide. Therefore, these neurotropic enteroviruses have been deemed as re-emerging pathogens. Although these viruses are becoming large threats to public health, our understanding of these viruses, especially for non-polio enteroviruses, is limited. In this article, we review recent advances in the trafficking of these pathogens from the peripheral to the central nervous system, compare their cell tropism, and discuss the effects of viral infections in their host neuronal cells.