bluuebunny/crossref_metadata_2025 huggingface dataset:
Regulation of Endothelial-to-Mesenchymal Transition by MicroRNAs in Chronic Allograft Dysfunction
Authors: Glover Emily K. , Jordan Nina , Sheerin Neil S. , Ali Simi
Published: March 2019

Fibrosis is a universal finding in chronic allograft dysfunction, and it is characterized by an accumulation of extracellular matrix. The precise source of the myofibroblasts responsible for matrix deposition is not understood, and pharmacological strategies for prevention or treatment of fibrosis remain limited. One source of myofibroblasts in fibrosis is an endothelial-to-mesenchymal transition (EndMT), a process first described in heart development and involving endothelial cells undergoing a phenotypic change to become more like mesenchymal cells. Recently, lineage tracing of endothelial cells in mouse models allowed studies of EndMT in vivo and reported 27% to 35% of myofibroblasts involved in cardiac fibrosis and 16% of isolated fibroblasts in bleomycin-induced pulmonary fibrosis to be of endothelial origin. Over the past decade, mature microRNAs (miRNAs) have increasingly been described as key regulators of biological processes through repression or degradation of targeted mRNA. The stability and abundance of miRNAs in body fluids make them attractive as potential biomarkers, and progress is being made in developing miRNA targeted therapeutics. In this review, we will discuss the evidence of miRNA regulation of EndMT from in vitro and in vivo studies and the potential relevance of this to heart, lung, and kidney allograft dysfunction.
Invasion-mediated effects on marine trophic interactions in a changing climate: positive feedbacks favour kelp persistence
Authors: Miranda Ricardo J. , Coleman Melinda A. , Tagliafico Alejandro , Rangel Maria S. , Mamo Lea T. , Barros Francisco , Kelaher Brendan P.
Published: March 2019

The interactive effects of ocean warming and invasive species are complex and remain a source of uncertainty for projecting future ecological change. Climate-mediated change to trophic interactions can have pervasive ecological consequences, but the role of invasion in mediating trophic effects is largely unstudied. Using manipulative experiments in replicated outdoor mesocosms, we reveal how near-future ocean warming and macrophyte invasion scenarios interactively impact gastropod grazing intensity and preference for consumption of foundation macroalgae (
Ecklonia radiata
and
Sargassum vestitum
). Elevated water temperature increased the consumption of both macroalgae through greater grazing intensity. Given the documented decline of kelp (
E. radiata
) growth at higher water temperatures, enhanced grazing could contribute to the shift from kelp-dominated to
Sargassum
-dominated reefs that is occurring at the low-latitude margins of kelp distribution. However, the presence of a native invader (
Caulerpa filiformis
) was related to low consumption by the herbivores on dominant kelp at warmer temperatures. Thus, antagonistic effects between climate change and a range expanding species can favour kelp persistence in a warmer future. Introduction of species should, therefore, not automatically be considered unfavourable under climate change scenarios. Climatic changes are increasing the need for effective management actions to address the interactive effects of multiple stressors and their ecological consequences, rather than single threats in isolation.
Stochastic models of polymerization based axonal actin transport
Authors: Chakrabarty Nilaj , Jung Peter
Published: March 2019

Pulse-chase and radio-labeling studies have shown that actin is transported in bulk along the axon at rates consistent with slow axonal transport. In a recent paper, using a combination of live cell imaging, super resolution microscopy and computational modeling, we proposed that biased polymerization of metastable actin fibers (actin trails) along the axon shaft forms the molecular basis of bulk actin transport. The proposed mechanism is unusual, and can be best described as molecular hitch hiking, where G-actin molecules are intermittently incorporated into actin fibers which grow preferably in anterograde direction giving rise to directed transport, released after the fibers collapse only to be incorporated into another fiber. In this paper, we use our computational model to make additional predictions that can be tested experimentally to further scrutinize our proposed mechanism for bulk actin transport. In the previous paper the caliber of our model axon, the density of the actin nucleation sites to form the metastable actin fibers, the length distribution of the actin trails and their growth rate were adapted to the biologic axons used for measurements. Here we predict how the transport rate will change with axon caliber, density of nucleation sites, nucleation rates and trail lengths. We also discuss why a simple diffusion-based transport mechanism can not explain bulk actin transport.
Voice Patterns in Schizophrenia: A systematic Review and Bayesian Meta-Analysis
Authors: Alberto Parola , Arndis Simonsen , Vibeke Bliksted , Riccardo Fusaroli
Published: March 2019

Voice atypicalities have been a characteristic feature of schizophrenia since its first definitions. They are often associated with core negative symptoms such as flat affect and alogia, and with the social impairments seen in the disorder. This suggests that voice atypicalities may represent a marker of clinical features and social functioning in schizophrenia. We systematically reviewed and meta-analyzed the evidence for distinctive acoustic patterns in schizophrenia, as well as their relation to clinical features. We identified 46 articles, including 55 studies with a total of 1254 patients with schizophrenia and 699 healthy controls. Summary effect sizes (Hedges’g and Pearson’s r) estimates were calculated using multilevel Bayesian modeling. We identified weak atypicalities in pitch variability (g= - 0.55) related to flat affect, and stronger atypicalities in proportion of spoken time, speech rate, and pauses (g’s between -0.75 and -1.89) related to alogia and flat affect. However, the effects were mostly modest (with the important exception of pause duration) compared to perceptual and clinical judgments, and characterized by large heterogeneity between studies. Moderator analyses revealed that tasks with a more demanding cognitive and social component showed larger effects both in contrasting patients and controls and in assessing symptomatology. In conclusion, studies of acoustic patterns are a promising but, yet unsystematic avenue for establishing markers of schizophrenia. We outline recommendations towards more cumulative, open, and theory-driven research.
Srrm234, but not canonical SR and hnRNP proteins drive inclusion of Dscam exon 9 variable exons
Authors: Ustaoglu Pinar , Haussmann Irmgard U. , Liao Hongzhi , Torres-Mendez Antonio , Arnold Roland , Irimia Manuel , Soller Matthias
Published: March 2019

Alternative splicing of pre-mRNA is a major mechanism to diversify protein functionality in metazoans from a limited number of genes. In the Drosophila melanogaster Down Syndrome Cell Adhesion Molecule (Dscam) important for neuronal wiring up to 38,016 isoforms can be generated by mutually exclusive alternative splicing in four clusters of variable exons. However, it is not understood how a specific exon is chosen from the many variables and how variable exons are prevented from being spliced together. A main role in the regulation of Dscam alternative splicing has been attributed to RNA binding proteins, but how they impact on exon selection is not well understood. Serine-arginine-rich (SR) proteins and hnRNP proteins are the two main types of RNA binding proteins with major roles in exon definition and splice site selection. Here, we analyzed the role of SR and hnRNP proteins in Dscam exon 9 alternative splicing in mutant Drosophila melanogaster embryos because of their essential function for development. Strikingly, loss or overexpression of canonical SR and hnRNP proteins even when multiple proteins are depleted together, does not affect Dscam alternative exon selection very dramatically. Conversely, non-canonical SR protein Serine-arginine repetitive matrix 2/3/4 (Srrm234) is a main determinant of exon inclusion in Dscam exon 9 cluster. Since long-range base-pairings are absent in the exon 9 cluster, our data argue for a small complement of regulatory factors as main determinants of exon inclusion in the Dscam exon 9 cluster.
Leveraging non-human primate multisensory neurons and circuits in assessing consciousness theory
Authors: Noel Jean-Paul , Ishizawa Yumiko , Patel Shaun R. , Eskandar Emad N. , Wallace Mark T.
Published: March 2019

Both the Global Neuronal Workspace (GNW) and Integrated Information Theory (IIT) posit that highly complex and interconnected networks engender perceptual awareness. GNW specifies that activity recruiting fronto-parietal networks will elicit a subjective experience, while IIT is more concerned with the functional architecture of networks than with activity within it. Here, we argue that according to IIT mathematics, circuits converging on integrative vs. convergent yet non-integrative neurons should support a greater degree of consciousness. We test this hypothesis by analyzing a dataset of neuronal responses collected simultaneously from primary somatosensory cortex (S1) and ventral premotor cortex (vPM) in non-human primates presented with auditory, tactile, and audio-tactile stimuli as they are progressively anesthetized with Propofol. We first describe the multisensory (audio-tactile) characteristics of S1 and vPM neurons (mean and dispersion tendencies, as well as noise-correlations), and functionally label these neurons as convergent or integrative according to their spiking responses. Then, we characterize how these different pools of neurons behave as a function of consciousness. At odds with the IIT mathematics, results suggest that convergent neurons more readily exhibit properties of consciousness (neural complexity and noise correlation) and are more impacted during the loss of consciousness than integrative neurons. Lastly, we provide support for the GNW by showing that neural ignition (i.e., same trial co-activation of S1 and vPM) was more frequent in conscious than unconscious states. Overall, we contrast GNW and IIT within the same single-unit activity dataset, and support the GNW.
Epha1 is a cell surface marker for neuromesodermal progenitors and their early mesoderm derivatives
Authors: de Lemos Luisa , Dias André , Nóvoa Ana , Mallo Moisés
Published: March 2019

The vertebrate body is built during embryonic development by the sequential addition of new tissue as the embryo grows at its caudal end. During this process, the neuro-mesodermal progenitors (NMPs) generate the postcranial neural tube and paraxial mesoderm. Recently, several approaches have been designed to determine their molecular fingerprint but a simple method to isolate NMPs from embryos without the need for transgenic markers is still missing. We isolated NMPs using a genetic strategy that exploits their self-renew properties, and searched their transcriptome for cell surface markers. We found a distinct Epha1 expression profile in progenitor-containing areas of the mouse embryo, consisting of two cell subpopulations with different Epha1 expression levels. We show that Sox2+/T+cells are preferentially associated with the Epha1 compartment, indicating that NMPs might be contained within this cell pool. Transcriptional profiling showed enrichment of high Epha1-expressing cells in known NMP and early mesoderm markers. Also, tail bud cells with lower Epha1 levels contained a molecular signature suggesting the presence of notochord progenitors. Our results thus indicate that Epha1 could represent a valuable cell surface marker for different subsets of axial progenitors, most particularly for NMPs taking mesodermal fates.
Developing a routine lab test for absolute quantification of Her2 in Formalin Fixed Paraffin Embedded (FFPE) breast cancer tissues using Quantitative Dot Blot (QDB) method
Authors: Yu Guohua , Zhang Wenfeng , Zhang Yunyun , Lv Jiahong , Zhang Jiandi , Tang Fangrong
Published: March 2019

While the transition from current prevailing method of relative and semi-quantitative assessment of solid tumor biomarkers to their absolute quantitation promises improved objectivity, consistency and accuracy in daily clinical practice, this transition is hindered by lacking of suitable technique, especially for Formalin Fixed Paraffin Embedded (FFPE) tissue samples. In this retrospective study, Quantitative Dot Blot (QDB) method was adopted to measure Her2 levels absolutely and quantitatively at protein level using 2X15 μm FFPE breast cancer tissue slices collected sequentially and non-selectively from local hospital. Her2 levels measured from 332 samples using two diagnostic antibodies respectively were strongly correlated (r=0.963, p=0.0000). When the result was evaluated with results from IHC or FISH analysis using Receiving Operating Characteristics (ROC) analysis, we were able to achieve 100% sensitivity (95% CI: 95.6% to 100%) and 99.3% specificity (95% CI: 96.14% to 99.98%) with results from IHC analysis using 0.267 nmole/g as cutoff, and 93.02% sensitivity (95%CI: 80.94% to 98.54%) and 93.68% specificity (95% CI: 86.76% to 97.65%) with results from FISH analysis using 0.261 nmole/g as cutoff. Thus, QDB method is demonstrated to provide objective and consistent assessment of Her2 levels in FFPE samples with comparable results from both IHC and FISH analyses. It is also the first method to achieve absolute quantitation of tissue biomarkers in FFPE samples to meet daily clinical need.
Laser Recording of Subcellular Neuron Activities
Authors: Chen Yu-Cheng , Li Xuzhou , Zhu Hongbo , Weng Wei-Hung , Tan Xiaotian , Chen Qiushu , Wang Xueding , Fan Xudong
Published: March 2019

Advances in imaging and recording of neural activities with a single neuron resolution have played a significant role in understanding neurological diseases in the past decade. Conventional methods relying on patch-clamp and electrodes are regarded as invasive, whereas fluorescence-based imaging tools are useful but still suffer from a low signal-to-noise ratio and low sensitivity. Here we developed a novel optical imaging and recording system by employing laser emissions to record the action potentials in single neurons and neuronal networks caused by subtle transients (Ca2+concentration) in primary neuronsin vitrowith a subcellular and single-spike resolution. By recording the laser emissions from neurons, we discovered that lasing emissions could be biologically modulated by intracellular activities and extracellular stimulation with >100-fold improvement in detection sensitivity over traditional fluorescence-based measurement. Finally, we showed that ultrasound can wirelessly activate neurons adsorbed with piezoelectric BaTiO3nanoparticles, in which the neuron laser emissions were modulated by ultrasound. Our findings show that ultrasound stimulation can significantly increase the lasing intensity and neuron network response. This work not only opens the door to laser emission recording of intracellular dynamics in neuronal networks but may provide an ultra-sensitive detection method for brain-on-chip applications, optogenetics, and neuro-analysis.
Rapid neural representations of personally relevant faces
Authors: Bayer Mareike , Berhe Oksana , Dziobek Isabel , Johnstone Tom
Published: March 2019

The faces of those most personally relevant to us are our primary source of social information, making their timely perception a priority. Recent research indicates that gender, age and identity of faces can be decoded from EEG/MEG data within 100ms. Yet the time course and neural circuitry involved in representing the personal relevance of faces remain unknown. We applied simultaneous EEG-fMRI to examine neural responses to emotional faces of female participants' romantic partners, friends, and a stranger. Combining EEG and fMRI in cross-modal representational similarity analyses, we provide evidence that representations of personal relevance start prior to structural encoding at 100ms, with correlated representations in visual cortex, but also in prefrontal and midline regions involved in value representation, and monitoring and recall of self-relevant information. Our results add to an emerging body of research that suggests that models of face perception need to be updated to account for rapid detection of personal relevance in cortical circuitry beyond the core face processing network.
Examining consumers’ luxury hotel stay repurchase intentions-incorporating a luxury hotel brand attachment variable into a luxury consumption value model
Authors: Peng Norman , Chen Annie
Published: March 2019

Purpose

Luxury consumption research has focused more on the consumers of goods than services, despite the trend that consumers are more interested in luxury services, such as luxury hospitality services, than ever before. Additionally, the results regarding the factors that can influence consumers’ luxury service product purchase intentions can be further tested. The purpose of this research is to examine the factors that contribute to consumers’ luxury hotel stay repurchase intentions, to further develop the luxury hospitality service consumption literature and to identify implications for practitioners to consider.

Design/methodology/approach

To contribute to the luxury consumption literature, this research incorporates a “luxury hotel brand attachment” variable into a luxury consumption value model to examine consumers’ intentions to repurchase luxury hotel stays when traveling for tourism purposes. The authors draw on a survey of over 450 luxury hotel consumers.

Findings

The findings confirm that luxury hotels’ perceived functional value, hedonic value and symbolic/expressive value affect consumers’ emotions, which in turn affects their luxury hotel attachment and repurchase intentions. In addition, luxury hotel attachment moderates the influence of emotion on repurchase intention.

Design/methodology/approach

Luxury hotels need to review their customers’ emotions during their stay and their attachment with the hotel. These factors can influence customers’ repurchase intentions. To stimulate customers’ emotions, luxury hotels need to offer functional value (e.g. attentive service staff), hedonic/expressive value (e.g. position as a form of self-indulgence) and symbolic value (e.g. conspicuous lobby). However, managers should know that having superior perceived functional value does not influence customers’ repurchase intentions directly. These characteristics may be commonly shared by most luxury hotels. Furthermore, they do not need to be too worried about providing financial value (e.g. value-for-money).

Originality/value

This study conceptualizes tourists’ luxury hotel stay intentions by examining the influence of perceived luxury value (i.e. functional value, financial value, hedonic value and symbolic/expressive value), tourists’ emotions and luxury hotel brand attachment. In addition, this research explores how luxury hotel brand attachment can moderate the relationship between consumers’ emotions and their repurchase intentions. Several implications of the study are identified, and avenues for future research are suggested.
Drop down or flee out?
Authors: Rapaport Carmit , Ashkenazi Isaac
Published: March 2019

Purpose

The official earthquake protection instructions for schools and kindergartens in Israel have recently been updated from the traditional “drop, cover and hold on” approach to the “flee outside to an open space” approach. This paper aims to describe the decision-making process, discuss the dilemmas behind it and suggest new insights for challenging current instructions in other countries.

Design/methodology/approach

The authors analyze human behavior patterns during earthquakes in general, and at schools in particular, while taking into consideration the environment (in terms of applying building codes and the level of earthquake risk in various zones), personal characteristics (age, gender and past experience) and earthquake characteristics (intensity and duration).

Findings

Five aspects should be taken into consideration when changing current earthquake instructions: the general official earthquake protection instructions, the structure and construction of schools and kindergartens, common behavior during emergencies, warning systems and the need to establish standardized protection instructions and guidelines for every school and kindergarten in the country.

Practical implications

Policymakers in other countries should critique current instructions to maximize citizens’ chances of survival and mitigate possible earthquake hazards, including by improving risk communication with the public.

Originality/value

The paper describes a national decision-making process which questions current official earthquake instructions at schools and kindergartens, based on evidence gained from current construction conditions, human behavior analysis and other countries’ experiences.
Legal family, cultural dimensions, and FDI
Authors: Steigner Tanja , Riedy Marian K. , Bauman Antonina
Published: March 2019

Purpose

The purpose of this paper is to investigate the interaction between legal origin and cultural distance and its impact on foreign direct investment (FDI) flows into the OECD.

Design/methodology/approach

Ordinary least squares regression analysis is used to evaluate FDI flows into OECD countries between 2003 and 2012. Estimations use fixed effects and clustered standard errors.

Findings

FDI flows from civil to common law countries are greater than vice versa. Further, cultural distance impacts FDI flows depending on the legal origin of the source country. Specifically, more FDI flows from civil and common law countries, when the host country has a higher (lower) power distance (individualism) score. Civil law countries send more FDI into countries with higher masculinity, uncertainty avoidance and indulgence scores and with lower long-term orientation scores. The opposite is the case with common law source countries. The findings remain robust for various changes to the sample selection.

Research limitations/implications

The concepts of cultural distance and legal origin have been criticized. However, neither concept has been rejected; rather, both concepts persist as robust empirical research tools.

Practical implications

Scholars, managers and investors can gauge the impact of cultural distance on FDI flows based on the legal family of the source country. Further, policy makers might want to consider rebranding their countries in terms of cultural perceptions to show the attractiveness of specific cultural dimensions to foreign companies and investors.

Originality/value

To the best of the authors’ knowledge, this is the first paper that jointly investigates FDI, legal origin and national culture.
A systemic inquiry into the delay factors in South African electrical distribution projects
Authors: Ntshangase Bonga , Tuan Nien-Tsu
Published: March 2019

Purpose

The purpose of this paper is to explore the delay factors in South African electrical distribution projects and demonstrate the interlaced relationship between the identified project delay factors.

Design/methodology/approach

This research employs interactive management (IM) methodology to construct a model achieving the research purpose. The IM methodology is anchored in the soft systems thinking. Its inquiry process mainly comprises four phases: idea generation, idea clarification, idea structuring and interpretation of the structured ideas. The IM methodology allows the relevant stakeholders to collaboratively develop a digraph displaying the interrelationship among the system elements.

Findings

The participants of the IM session structured a systemic model showing that a loop comprising three factors is the driver leading to the delays in the electrical distribution projects. The three delay factors in the loop are “poor communication”, “poor planning” and “project scheduling not properly done”.

Originality/value

The findings show that a loop comprising three delay factors is the driver leading to the project delays. This result is different from the outputs of the commonly used approaches. The three identified root causes serve as the starting point for eradicating delays in the electrical distribution projects.
Overcoming destructive deviance: propositioning an integrated conceptual framework
Authors: Malik Pooja , Lenka Usha
Published: March 2019

Purpose

This study aims to provide a review of antecedents of destructive deviance and classify them into three levels, namely, personal, interpersonal and organizational level in the proposed integrated conceptual framework. Furthermore, it proposes three levels of interventions to prevent or modify destructive deviance.

Design/methodology/approach

Systematic literature review of the past 23 years was carried out for the current study to identify the antecedents of destructive deviance.

Findings

This study proposes an integrated conceptual framework incorporating three levels of antecedents and interventions for overcoming destructive deviance. Findings classified the antecedents of destructive deviance into three categories, namely, personal, interpersonal and organizational level variables. Similarly, the proposed interventions were classified into three levels, namely, individual (employee resilience, mindfulness), interpersonal (mentoring, peer support) and organizational-level interventions (talent management, internal corporate communication) that organizations should concentrate on to reduce destructive deviance and facilitate health and well-being of employees.

Practical implications

This study posits three-level interventions to reduce or transform negative characteristics and overcome the negative impact of interpersonal and organizational level antecedents on destructive deviance among employees. The suggested three-level interventions not only reduce the negative characteristics and transform negative behaviors but also lay a significant pavement for fostering positive emotions among employees.

Originality/value

This study classifies the antecedents of destructive deviance into three categories, namely, personal, interpersonal and organizational-level antecedents. Further, this study offers three-level interventions for overcoming destructive deviance among employees.
Performance modeling and optimization for complex repairable system of paint manufacturing unit using a hybrid BFO-PSO algorithm
Authors: Kumar Amit , Kumar Vinod , Modgil Vikas
Published: March 2019

Purpose

The purpose of this paper is to optimize the performance for complex repairable system of paint manufacturing unit using a new hybrid bacterial foraging and particle swarm optimization (BFO-PSO) evolutionary algorithm. For this, a performance model is developed with an objective to analyze the system availability.

Design/methodology/approach

In this paper, a Markov process-based performance model is put forward for system availability estimation. The differential equations associated with the performance model are developed assuming that the failure and repair rate parameters of each sub-system are constant and follow the exponential distribution. The long-run availability expression for the system has been derived using normalizing condition. This mathematical framework is utilized for developing an optimization model in MATLAB 15 and solved through BFO-PSO and basic particle swarm optimization (PSO) evolutionary algorithms coded in the light of applicability. In this analysis, the optimal input parameters are determined for better system performance.

Findings

In the present study, the sensitivity analysis for various sub-systems is carried out in a more consistent manner in terms of the effect on system availability. The optimal failure and repair rate parameters are obtained by solving the performance optimization model through the proposed hybrid BFO-PSO algorithm and hence improved system availability. Further, the results obtained through the proposed evolutionary algorithm are compared with the PSO findings in order to verify the solution. It can be clearly observed from the obtained results that the hybrid BFO-PSO algorithm modifies the solution more precisely and consistently.

Research limitations/implications

There is no limitation for implementation of proposed methodology in complex systems, and it can, therefore, be used to analyze the behavior of the other repairable systems in higher sensitivity zone.

Originality/value

The performance model of the paint manufacturing system is formulated by utilizing the available uncertain data of the used manufacturing unit. Using these data information, which affects the performance of the system are parameterized in the input failure and repair rate parameters for each sub-system. Further, these parameters are varied to find the sensitivity of a sub-system for system availability among the various sub-systems in order to predict the repair priorities for different sub-systems. The findings of the present study show their correspondence with the system experience and highlight the various availability measures for the system analyst in maintenance planning.
A hybrid decision making framework for modified failure mode effects and criticality analysis
Authors: Gugaliya Agam , Boral Soumava , Naikan V.N.A.
Published: March 2019

Purpose

Assessing the severity of failure modes of critical industrial machinery is often considered as an onerous task and sometimes misinterpreted by shop-floor engineer/maintenance personnel. The purpose of this paper is to develop an improved FMECA method for prioritizing the failure modes as per their risk levels and validating the same through a real case study of induction motors used in a process plant.

Design/methodology/approach

This paper presents a novel hybrid multi-criteria decision-making (MCDM) approach to prioritize different failure modes according to their risk levels by combining analytical hierarchy process (AHP) with a newly introduced MCDM approach, election based on relative value distance (ERVD). AHP is incorporated in the proposed approach to determine the criteria weights, evaluated in linguistic terms by industrial expert. Furthermore, ERVD, which is based on the concept of prospect theory of human cognitive process, is applied to rank the potential failure modes.

Findings

It is found that the proposed FMECA approach provides better results in accordance with the actual industrial scenario and helps in effectively prioritizing the failure modes. A comparison is also made to highlight the differences of results between the proposed approach with TOPSIS and conventional FMECA.

Research limitations/implications

This research paper proposes an improved FMECA method and, thus, provides a deep insight to maintenance managers for effectively prioritizing the failure modes. The correct prioritization of failure modes will help in effective maintenance planning, thus reducing the downtime and improving profit to the organization.

Practical implications

A real case of process plant induction motor has been introduced in the research paper to show the applicability of this decision-making approach, and the approach is found to be suitable in correct prioritization of the failure modes.

Originality/value

Severity has been decoupled into various factors affecting it, to make it more relevant as per actual industrial scenario. Then, a novel modified FMECA has been developed using a hybrid MCDM approach (AHP and ERVD). This hybrid method, as well as its application in FMECA, has not been developed by any previous researcher. Moreover, the same has been thoroughly explained by considering a real case of process plant induction motors and validated with cross-functional experts.
Managing risk for auto warranties
Authors: Aljazea Ahmed M. , Wu Shaomin
Published: March 2019

Purpose

The purpose of this paper is threefold: first, to analyse the existing work of warranty risk management (WaRM); second, to develop a generic WaRM framework; and third, to design a generic taxonomy for warranty hazards from a warranty chain perspective.

Design/methodology/approach

To understand the top warranty hazards, the authors designed a questionnaire, received 40 responses from the warranty decision makers (WDM) in the automotive industry in the UK and then analysed the responses.

Findings

The assembly process capability at suppliers is the top contributor to warranty incidents from the suppliers’ and original equipment manufacturers’ (OEMs’) viewpoints. The human error at different stages of the product lifecycle contributes to the occurrence of warranty incidents. The collaboration among parties, particularly, the accessibility to warranty-related data between parties (i.e. suppliers, OEM and dealers), is limited. Customers’ fraud contributes more to warranty costs than warranty services providers’ fraud. The top contributors to customer dissatisfaction relating to warranty are the warranty service time and service quality.

Research limitations/implications

The questionnaires were used to collect data in the UK, which implies the research outcomes of this paper may only reflect the UK area.

Practical implications

The WaRM framework and taxonomy proposed in this paper provide WDM with a holistic view to identifying the top contributors to warranty incidents. With them, the decision makers will be able to allocate the required fund and efforts more effectively.

Originality/value

This paper contributes to the literature by providing the first work of systematically analysing the top contributors to warranty incidents and costs and by providing a WaRM framework.
Critical factors of effective implementation of IT-enabled ISO-9000 QMS
Authors: Kharub Manjeet
Published: March 2019

Purpose

Although aligning information technology (IT) with quality management (QM) is a popular concept, it has not yet been properly, theoretically and empirically grounded. Therefore, the purpose of this paper is to identify critical factors for the effective implementation (CFEI) of IT-enabled ISO-9000 quality management system (QMS).

Design/methodology/approach

The primary field data were collected through a questionnaire survey of 381 small and medium enterprises (SMEs) in India. Exploratory factor analysis and confirmatory factor analysis were applied to check the reliability and validity of the data collected. First, using pattern matrix, 48 items (extracted from relevant literature) representing CFEI of IT-enabled ISO-9000 QMS were grouped into six latent variables (eigenvalue⩾1). Second, to test the relationship among CFEI, firm performance and competitive positioning, six hypotheses were formulated and tested using structural equation modelling (SEM) procedure.

Findings

The study results found that identified CFEI of IT-enabled ISO-9000 QMS, i.e. “strategic attributes” (β=0.517), “tactical attributes” (β=0.323), “operational attributes” (β=0.281), “organisational infrastructure and processes” (β=0.231), “system knowledge” (β=0.194), “alignment of system with firm’s strategy” (β=0.230), have a significant effect (p<0.05) on the successful implementation of ISO-9000 QMS. The critical factors are found to have a direct and positive impact on the firm’s performance. Study results found that the critical factors do not directly affect the firm’s competitive positioning (β=−0.097), but they do so indirectly through customer satisfaction (β=0.627) and operational performance (β=0.482).

Originality/value

The proposed model provides critical factors to align IT system with ISO-9000 QMS which is highly required mainly for SMEs. The study will provide a mean by which small manufacturing firms can counter the effects of increasing global competition.
Influence of everyday stress: mechanisms that elicit excitation transfer and dark behavior
Authors: Tetreault Christie , Hoff Eva
Published: March 2019

Purpose

The purpose of this paper is to explore if a ringing cell phone could impact cognitive performance as well as being agitating to provoke aggressive reactions. The study investigated variables that could impact a participant’s willingness to aggress and retaliate, such as sensitivity to arousal and dark personalities (DRPs), Machiavellianism, narcissism, and subclinical psychopathy and sadism.

Design/methodology/approach

There were 128 participants (77 women and 51 men). The cognitive load task consisted of forming anagrams while being in a high or low provocation condition. Participants were subsequently asked how willing they would be to allow one out-group member to be harmed in favor of saving several in-group members. Three personality measures were used: two measuring DRPs and one measuring arousal sensitivity.

Findings

The authors discovered that older age and subclinical psychopathy were significant predictors for the willingness to aggress. Those in the high provocation condition retaliated the most against the experimenter, and a participant’s English ability was the only variable that predicted good performance on the cognitive task.

Originality/value

The results warrant further research into how personality types, aggression, and everyday, multiple arousal sources intertwine to inform personalized evidence-based interventions. Organizational and educational psychologists could also use this research to in form how offices and schools are run.
Asset specificity, intensity of coordination, and the choice of hybrid governance structures
Authors: Meirelles de Souza Filho Hildo , Varella Miranda Bruno
Published: March 2019

Purpose

The purpose of this paper is to discuss the relationship between the existence of asset specificity and the architecture of the hybrid governance structures adopted by horticultural smallholders from the Brazilian region of Serra Fluminense.

Design/methodology/approach

This paper uses a negative binomial regression model to analyze 567 transactions carried out by horticultural smallholders from the Brazilian region of Serra Fluminense. Starting from the insights of Oliver Williamson’s transaction cost economics, an indicator is constructed with the goal to capture the degree of intensity of coordination from the adoption of diverse bundles of coordination mechanisms in a governance structure.

Findings

The results show that higher levels of human and physical asset specificity affect the intensity of coordination of the transactions in the sample, leading to the adoption of hybrid forms with more complex bundles of coordination mechanisms.

Research limitations/implications

This paper adds to a growing literature that studies the architecture of complex governance structures. However, its empirical conclusions are exploratory.

Originality/value

The contribution of this paper is twofold. First, quantitative empirical studies that analyze the diversity of hybrid forms in the same industry are relatively rare. This contribution also presents a theoretical discussion that might inform scholars dealing with similar research challenges.
Teachers’ use of digital learning tool for teaching in higher education
Authors: Mei Xiang Ying , Aas Endre , Medgard Magnhild
Published: March 2019

Purpose

The purpose of this paper is to explore teachers’ use of digital learning tools for teaching in higher education. Moreover, it investigates how the use of digital tools affects educational practices and how teachers experience the culture of sharing among colleagues and within the organisation.

Design/methodology/approach

A qualitative methodology was chosen, and semi-structured interviews were conducted with teachers at a higher education institution in Norway. The study uses the TPACK-framework, which illustrates the relationship between technology, professional content knowledge and pedagogical approaches as its theoretical foundation.

Findings

The findings conclude that teachers are concerned with the convergence of how technology and digital learning tools can support educational processes by engaging and involving the students. The findings further indicate that they are committed to using digital tools to motivate, engage and facilitate student-based education, which in turn leads to more reflection on teachers’ own teaching practices. Based on the theory of Professional Learning Communities, the respondents agree that sharing is a basic prerequisite for a learning organisation. They experience, however, that sharing between colleagues is easier in formal forums than at informal settings.

Originality/value

The rapid development of technology suggests that many sectors including the education sector must adapt to the new changes in their teaching practices. Nevertheless, many teachers merely use the basic form of digital learning tools to distribute the teaching materials, as such tools are less utilised to support students’ learning process (Fossland, 2015). The research indicates that digital learning tools have positive effect on teaching practices and that they can function as tools to improve the teachers’ own teaching practices. Positive teaching practices should also be shared in a learning organisation to improve teaching practices on an organisational level. Hence, sharing at a professional level can impact learning and the organisational culture in academic institutions.
The impact of new working practices on employee productivity
Authors: Wadu Mesthrige Jayantha , Chiang Yat Hung
Published: March 2019

Purpose

This study aims to analyse the impact on employee productivity of adopting the activity-based working (ABW) a form of new work practices (NWPs). A study of this nature has never been made in Asia.

Design/methodology/approach

A mixed methods design was used, which combined a comprehensive literature review, three interviews with senior professionals and a questionnaire survey with 37 office occupiers all from one international real estate consultancy firm in Hong Kong, as a case study, to analyse the impact of ABW on employee productivity.

Findings

Findings suggest that ABW influences employee productivity to a certain degree. Though both physical and behavioural working environmental factors influence employee productivity in general, the latter factors were relatively more influential. Interestingly, though space-per-employee has been reduced under the ABW, this has not affected employee performance negatively. However, findings indicate that distraction elements (e.g. interruptions, overcrowding and noise) do have a negative influence on employee performance.

Research limitations/implications

The scope of this exploratory study is limited to Hong Kong and to a small sample of respondents representing one international real estate firm. However, the results could be interpreted for critical learning in other similarly expensive real estate rental markets.

Originality/value

The study highlighted the impact of not only physical but also behavioural working environment factors on employee productivity. The maximum benefits of NWPs can only be accomplished by striking a balance between aspects of physical and behavioural working environments.
Using self-determination theory to assess the service product at a wellness facility: a case study
Authors: Thal Karen , Hudson Simon
Published: March 2019

Purpose

The purpose of this paper is to propose and test a theoretical framework to identify the specific aspects of the guest experience at a wellness facility that contribute to well-being. Self-determination theory (SDT) is used as the theoretical framework. According to SDT, basic needs must be met in order for psychological well-being to be achieved. Thus, in addition to the services and amenities offered, the quality of interactions with staff and service providers are integral to wellness vacation outcomes or basic need fulfillment.

Design/methodology/approach

Psychological precursors, or basic needs, were estimated using structural equation modeling, and these precursors were significant with the model explaining considerable variation in the outcome variable, well-being.

Findings

The results suggest that guest experiences can be enhanced if management facilitates guest autonomy, helps guests develop a sense of mastery with respect to activities and encourages positive interactions between guests.

Research limitations/implications

Study limitations include the single venue used for data collection, sample size and a focus on exercise activities as a proxy for staff–guest interactions.

Practical implications

This study sheds light on an under-researched area, providing managerial guidelines for wellness tourism destinations with respect to service delivery.

Originality/value

This study extends the wellness tourism literature by suggesting a framework to assess the service product and optimize guest experiences within the niche wellness sector of the tourism and hospitality industry.
Examining learning transformation in project-based learning process
Authors: Pan Gary , Seow Poh-Sun , Koh Grace
Published: March 2019

Purpose

The purpose of this paper is to present a learning transformation framework for analyzing how learning evolves during project-based learning (PBL) process. Here, the authors adopt Lewin’s (1951) change theory as an analytical lens to examine the project-based learning curriculum at a University called UNI-X. This is a major contribution to PBL literature, as little is known about the dynamics of learning during PBL process. In fact, the learning transformation framework can serve as the basis for further research in PBL process. For educators, this paper provides them with useful insights on how to break project members’ escalating commitment to previous failing ideas and accept alternative workable ideas. Educators can use the framework in post-mortem analyses of projects to devise useful actions for facilitating learning transformation during PBL process.

Design/methodology/approach

The strategy used in this paper was to undertake in-depth case research of PBL courses developed and taught in UNI-X. Focused group interviews were conducted with 28 students, 12 faculty and 5 industry project sponsors asking specifically their perceptions of PBL’s course design, delivery and its impact on overall student experience.

Findings

This paper presents a learning transformation framework for analyzing the change process of how learners experiment new ideas, explore alternative ideas and eventually come to a consensus to accept new ideas during PBL in a collaborative project environment. By drawing upon a case study of UNI-X, the authors argue that unfreezing beliefs of previous ideas is critical if alternative ideas are to be developed. It is clear that the entire process of ‘unfreezing-changing-refreezing’ has occurred in the PBL courses at UNI-X and enacted through unfreezing beliefs in previous ideas, changing previous beliefs and refreezing the new beliefs. Through interviews with students, instructors and project sponsors in the PBL courses, the authors gathered data to examine how project members could give up previous ideas and accept alternative ideas.

Originality/value

The authors adopt Lewin’s (1951) change theory as an analytical lens to examine the project-based learning curriculum at UNI-X. This is a major contribution to PBL literature, as little is known about the dynamics of learning during PBL process. In fact, the learning transformation framework can serve as the basis for further research in PBL process.