bluuebunny/crossref_metadata_2025 huggingface dataset:
Socially vs. Privately Optimal Control of Livestock Diseases: A Case for Integration of Epidemiology and Economics
Authors: Mendes Ângelo J. , Haydon Daniel T. , McIntosh Emma , Hanley Nick , Halliday Jo E. B.
Published: November 2020

This paper aims to illustrate the interdependencies between key epidemiological and economic factors that influence the control of many livestock infectious diseases. The factors considered here are (i) farmer heterogeneity (i.e., differences in how farmers respond to a perceived disease risk), (ii) off-farm effects of farmers' actions to control a disease (i.e., costs and benefits borne by agents that are external to the farm), and (iii) misalignment between privately and socially optimal control efforts (i.e., privately optimal behavior not conducive to a socially optimal outcome). Endemic chronic diseases cause a wide range of adverse social and economic impacts, particularly in low-income countries. The actions taken by farmers to control livestock diseases minimize some of these impacts, and heterogeneity in those actions leads to variation in prevalence at the farm level. While some farmers respond to perceived disease risks, others free-ride on the actions of these individuals, thereby compromising the potential benefits of collective, coordinated behavior. When evaluating a plausible range of disease cost to price of control ratios and assuming that farmers choose their privately optimal control effort, we demonstrate that achievement of a socially optimal disease control target is unlikely, occurring in <25% of all price-cost combinations. To achieve a socially optimal disease control outcome (reliant on farmers' voluntary actions), control policies must consider farmer heterogeneity, off-farm effects, and the predicted uptake of control measures under the assumption of optimized behavior.
A Review of the Current Status of Peste des Petits Ruminants Epidemiology in Small Ruminants in Tanzania
Authors: Idoga Enokela S. , Armson Bryony , Alafiatayo Ruth , Ogwuche Adah , Mijten Erik , Ekiri Abel B. , Varga Gabriel , Cook Alasdair J. C.
Published: November 2020

Peste des petits ruminants (PPR) is a highly contagious viral disease of sheep and goats with high mortality. The disease is of considerable economic importance in countries such as Tanzania, where small ruminant products are important for sustainable livelihoods. This review assesses current knowledge regarding the epidemiology of PPRV in Tanzania, highlighting the challenges with respect to control and suggesting possible interventions. Thirty-three articles were identified after literature searches using Google Scholar and PubMed. Studies revealed that PPRV is endemic in sheep and goats in Tanzania, although seropositivity has also been reported in cattle, camels, buffalo, Grant's gazelle, wildebeest and impala, but with no clinical manifestation. Three lineages (lineage II to IV) of PPRV have been identified in Tanzania, implying at least two separate introductions of the virus. Diagnosis of PPR in Tanzania is mostly by observation of clinical signs and lesions at post mortem. Risk factors in Tanzania include age, sex, species, and close contact of animals from different farms/localities. Although there is an efficacious vaccine available for PPR, poor disease surveillance, low vaccine coverage, and uncontrolled animal movements have been the bane of control efforts for PPR in Tanzania. There is need for collaborative efforts to develop interventions to control and eradicate the disease. The establishment of a national reference laboratory for PPR, conduct of surveillance, the development of high-quality DIVA vaccines, as well as execution of a carefully planned national vaccination campaign may be key to the control and subsequent eradication of PPR in Tanzania and achieving the global goal of eradicating PPR by 2030.
Changes in Arterial Blood Pressure and Oxygen Tension as a Result of Hoisting in Isoflurane Anesthetized Healthy Adult Horses
Authors: Cerullo Michelle , Driessen Bernd , Douglas Hope , Hopster Klaus
Published: November 2020

Background: In anesthetized adult horses, changes in recumbency can influence the cardiovascular system but how arterial blood pressures and oxygen tension change in isoflurane anesthetized animals as a direct result of hoisting has not been investigated.

Objective: To evaluate effects of hoisting on hemodynamic function and pulmonary gas exchange in isoflurane-anesthetized horses.

Study Design: Prospective, experimental study.

Methods: Six adult horses were anesthetized three times using isoflurane in pure oxygen (inspired fraction 0.9–1.0), and allowed breathing spontaneously in lateral recumbency. After 45 min horses were hoisted using a single hoist-hobble system for 5 min and returned into left lateral recumbency. Heart rate (HR), respiratory rate (RR), and systolic (SAP), diastolic (DAP), and mean arterial blood pressures (MAP) were measured every minute starting from 5 min before to 5 min after hoisting. Arterial blood gas samples were collected before, during, and after hoisting.

Results: Significant changes in hemodynamic parameters and PaO2 but not PaCO2 were found between baseline recordings and measurements obtained during and early after hoisting. The MAP decreased within the 1st min of hoisting from a mean of 74 ± 17 mmHg at baseline to 57 ± 20 mmHg (p < 0.05). Thereafter, it rapidly recovered to baseline before continuing to rise to higher than baseline values and then remaining elevated for 5 min after horses were returned into lateral recumbency. Simultaneously, the HR increased by 6–9 beats per min during the initial 3 min of hoisting before returning close to baseline values (p < 0.05). The PaO2 decreased significantly from a mean of 324.9 ±137.0 mmHg at baseline to a mean of 141.3 ± 104.2 mmHg during hoisting (p < 0.001) without recovering any more to baseline values.

Clinical significance: Hoisting an adult horse during or at the end of isoflurane anesthesia carries the risk of a precipitous, though short-lived (1–2 min), drop in arterial blood pressures and a persistent decrease in arterial oxygenation. While in systemically healthy animals the observed functional impairments were not life-threatening, they may be more severe in systemically compromised horses.Therefore, arterial blood pressures and oxygenation must be carefully monitored when hoisting sick equine patients during or at the end of inhalant anesthesia.
Genome-Wide Analysis of the β-Amylase Gene Family in Brassica L. Crops and Expression Profiles of BnaBAM Genes in Response to Abiotic Stresses
Authors: Luo Dan , Jia Ziqi , Cheng Yong , Zou Xiling , Lv Yan
Published: November 2020

The β-amylase (BAM) gene family, known for their property of catalytic ability to hydrolyze starch to maltose units, has been recognized to play critical roles in metabolism and gene regulation. To date, BAM genes have not been characterized in oil crops. In this study, the genome-wide survey revealed the identification of 30 BnaBAM genes in Brassica napus L. (B. napus L.), 11 BraBAM genes in Brassica rapa L. (B. rapa L.), and 20 BoBAM genes in Brassica oleracea L. (B. oleracea L.), which were divided into four subfamilies according to the sequence similarity and phylogenetic relationships. All the BAM genes identified in the allotetraploid genome of B. napus, as well as two parental-related species (B. rapa and B. oleracea), were analyzed for the gene structures, chromosomal distribution and collinearity. The sequence alignment of the core glucosyl-hydrolase domains was further applied, demonstrating six candidate β-amylase (BnaBAM1, BnaBAM3.1-3.4 and BnaBAM5) and 25 β-amylase-like proteins. The current results also showed that 30 BnaBAMs, 11 BraBAMs and 17 BoBAMs exhibited uneven distribution on chromosomes of Brassica L. crops. The similar structural compositions of BAM genes in the same subfamily suggested that they were relatively conserved. Abiotic stresses pose one of the significant constraints to plant growth and productivity worldwide. Thus, the responsiveness of BnaBAM genes under abiotic stresses was analyzed in B. napus. The expression patterns revealed a stress-responsive behaviour of all members, of which BnaBAM3s were more prominent. These differential expression patterns suggested an intricate regulation of BnaBAMs elicited by environmental stimuli. Altogether, the present study provides first insights into the BAM gene family of Brassica crops, which lays the foundation for investigating the roles of stress-responsive BnaBAM candidates in B. napus.
Semen Modulates Inflammation and Angiogenesis in the Reproductive Tract of Female Rabbits
Authors: Gardela Jaume , Jauregi-Miguel Amaia , Martinez Cristina A. , Rodríguez-Martinez Heriberto , López-Béjar Manel , Álvarez-Rodríguez Manuel
Published: November 2020

The maternal environment modulates immune responses to facilitate embryo development and ensure pregnancy. Unraveling this modulation could improve the livestock breeding systems. Here it is hypothesized that the exposure of the female rabbit reproductive tract to semen, as well as to early embryos, modulates inflammation and angiogenesis among different tissue segments. qPCR analysis of the gene expression changes of the anti-inflammatory interleukin-10 (IL10) and transforming growth factor beta family (TGFβ1–3) and the angiogenesis mediator vascular endothelial growth factor (VEGF-A) were examined in response to mating or insemination with sperm-free seminal plasma (SP). Reproductive tract segment (cervix to infundibulum) samples were obtained in Experiment 1, 20 h after gonadotropin-releasing hormone (GnRH) stimulation (control), natural mating (NM) or vaginal infusion with sperm-free SP (SP-AI). Additionally, segmented samples were also obtained at 10, 24, 36, 68 or 72 h after GnRH-stimulation and natural mating (Experiment 2). The results of gene expression, analyzed by quantitative PCR, showed that NM effects were mainly localized in the uterine tissues, depicting clear temporal variation, while SP-AI effects were restricted to the oviduct. Changes in anti-inflammatory and angiogenesis mediators indicate an early response in the uterus and a late modulation in the oviduct either induced by semen or preimplantation embryos. This knowledge could be used in the implementation of physiological strategies in breeding systems to face the new challenges on rabbit productivity and sustainability.
Increased Stopover Duration and Low Body Condition of the Pied Flycatcher (Ficedula hypoleuca) at an Autumn Stopover Site
Authors: Goffin Bernice , Felgueiras Marcial , Hof Anouschka R.
Published: November 2020

Many long-distance migratory bird species are in decline, of which environmental changes, such as climate change and land-use changes, are thought to be important drivers. The effects of environmental change on the migration of these birds have often been studied during spring migration. Fewer studies have explored the impacts of environmental change on autumn migration, especially at stopover sites. However, stopover sites are important, as the quality of these sites is expected to change over time. We investigated impacts of local environmental conditions on the migration strategy and body condition of the Pied Flycatcher (Ficedula hypoleuca) at an autumn migration stopover site using long-term ringing data (1996–2018) and local environmental conditions. We found that although the arrival and departure dates of birds at the stopover site remained unchanged, the body condition (fat score) of the individuals caught decreased, and the stopover duration increased. This suggests that conditions at the stopover site during the autumn migration period have deteriorated over time. This study emphasizes the importance of suitable stopover sites for migratory birds and stresses that changes in environmental conditions during the autumn migration period may be contributing to the current decline in long-distance migratory passerines.
Donkey Epididymal Transport for Semen Cooling and Freezing
Authors: Lago-Alvarez Yamilka , Podico Giorgia , Segabinazzi Lorenzo G. , Cunha Lais L. , Barbosa Leonardo , Arnold Carolyn E. , Lima Fabio S. , King Luise T. , McLean Amy K. , Canisso Igor F.
Published: November 2020

The objectives of this study were to assess the cooling and freezing of donkey epididymal semen harvested immediately after castration (Experiment 1, n = 4) or after the shipment (24 or 48 h) of epididymides attached to testicles (Experiment 2, n = 14) or dissected apart (Experiment 3, n = 36). In each experiment, semen was frozen immediately (Non-Centrif) in an egg yolk-based semen extender (EY) or after processing through cushion-centrifugation (Centrif) while extended in a skim milk-based extender (SC). In all three experiments, cooled, pre-freeze, and post-thaw epididymal semen was assessed for total motility (TM), progressive motility (PM), plasma membrane integrity (PMI), and high mitochondrial membrane potential (HMMP). Data were analyzed with R using mixed models and Tukey’s test as posthoc. Results showed that the cooling of epididymal semen up to 24 h after harvesting did not affect motility parameters or plasma membrane integrity; furthermore, in Experiment 3, the post-thaw evaluation of both Centrif and Non-Centrif achieved similar TM and PM. Collectively, the post-thaw results revealed low motility parameters across groups; while, the PMI and HMMP did not reflect this trend, and the values remained high, suggesting that there was a lack of epididymal sperm activation with either centrifugation or extenders. In summary, freshly harvested and cooled-shipped and cooled semen had satisfactory semen parameters. Future studies need to address donkey epididymal semen fertility in mares and jennies.
Effects of Transient Loss of Vision on Head and Eye Movements during Visual Search in a Virtual Environment
Authors: David Erwan , Beitner Julia , Võ Melissa Le-Hoa
Published: November 2020

Central and peripheral fields of view extract information of different quality and serve different roles during visual tasks. Past research has studied this dichotomy on-screen in conditions remote from natural situations where the scene would be omnidirectional and the entire field of view could be of use. In this study, we had participants looking for objects in simulated everyday rooms in virtual reality. By implementing a gaze-contingent protocol we masked central or peripheral vision (masks of 6 deg. of radius) during trials. We analyzed the impact of vision loss on visuo-motor variables related to fixation (duration) and saccades (amplitude and relative directions). An important novelty is that we segregated eye, head and the general gaze movements in our analyses. Additionally, we studied these measures after separating trials into two search phases (scanning and verification). Our results generally replicate past on-screen literature and teach about the role of eye and head movements. We showed that the scanning phase is dominated by short fixations and long saccades to explore, and the verification phase by long fixations and short saccades to analyze. One finding indicates that eye movements are strongly driven by visual stimulation, while head movements serve a higher behavioral goal of exploring omnidirectional scenes. Moreover, losing central vision has a smaller impact than reported on-screen, hinting at the importance of peripheral scene processing for visual search with an extended field of view. Our findings provide more information concerning how knowledge gathered on-screen may transfer to more natural conditions, and attest to the experimental usefulness of eye tracking in virtual reality.
Emotional Components of Pain Perception in Borderline Personality Disorder and Major Depression—A Repetitive Peripheral Magnetic Stimulation (rPMS) Study
Authors: Malejko Kathrin , Huss André , Schönfeldt-Lecuona Carlos , Braun Maren , Graf Heiko
Published: November 2020

Various studies suggested alterations in pain perception in psychiatric disorders, such as borderline personality disorder (BPD) and major depression (MD). We previously investigated affective components of pain perception in BPD compared to healthy controls (HC) by increasing aversive stimulus intensities using repetitive peripheral magnetic stimulation (rPMS) and observed alterations in emotional rather than somatosensory components in BPD. However, conclusions on disorder specific alterations in these components of pain perception are often limited due to comorbid depression and medication in BPD. Here, we compared 10 patients with BPD and comorbid MD, 12 patients with MD without BPD, and 12 HC. We applied unpleasant somatosensory stimuli with increasing intensities by rPMS and assessed pain threshold (PT), cutaneous sensation, emotional valence, and arousal by a Self-Assessments Manikins scale. PTs in BPD were significantly higher compared to HC. The somatosensory discrimination of stimulus intensities did not differ between groups. Though elevated rPMS intensities led to increased subjective aversion and arousal in MD and HC, these emotional responses among intensity levels remained unchanged in BPD. Our data give further evidence for disorder-specific alterations in emotional components of pain perception in BPD with an absent emotional modulation among varying aversive intensity levels.
Research Objectives, Statistical Analyses and Interpretation of Health-Related Quality of Life Data in Glioma Research: A Systematic Review
Authors: Coomans Marijke B. , Peeters Marthe C.M. , Koekkoek Johan A.F. , Schoones Jan W. , Reijneveld Jaap , Taphoorn Martin J.B. , Dirven Linda
Published: November 2020

Background: Health-related quality of life (HRQoL) has become an increasingly important patient-reported outcome in glioma studies. Ideally, collected HRQoL data should be exploited to the full, with proper analytical methods. This systematic review aimed to provide an overview on how HRQoL data is currently evaluated in glioma studies, focusing on the research objectives and statistical analyses of HRQoL data. Methods: A systematic literature search in the databases PubMed, Embase, Web of Science and Cochrane was conducted up to 5 June 2020. Articles were selected based on predetermined inclusion criteria and information on study design, HRQoL instrument, HRQoL research objective and statistical methods were extracted. Results: A total of 170 articles describing 154 unique studies were eligible, in which 17 different HRQoL instruments were used. HRQoL was the primary outcome in 62% of the included articles, and 51% investigated ≥1 research question with respect to HRQoL, for which various analytical methods were used. In only 42% of the articles analyzing HRQoL results over time, the minimally clinical important difference was reported and interpreted. Eighty-six percent of articles reported HRQoL results at a group level only, and not at the individual patient level. Conclusion: Currently, the assessment and analysis of HRQoL outcomes in glioma studies is highly variable. Opportunities to maximize information obtained with HRQoL data include appropriate and complementary analyses at both the group and individual level, comprehensive reporting of HRQoL results in separate articles or supplementary material, and adherence to existing guidelines about the assessment, analysis and reporting of patient-reported outcomes.
Overshooting Subcellular Redox-Responses in Rett-Mouse Hippocampus during Neurotransmitter Stimulation
Authors: Festerling Karina , Can Karolina , Kügler Sebastian , Müller Michael
Published: November 2020

Rett syndrome (RTT) is a neurodevelopmental disorder associated with disturbed neuronal responsiveness and impaired neuronal network function. Furthermore, mitochondrial alterations and a weakened cellular redox-homeostasis are considered part of the complex pathogenesis. So far, overshooting redox-responses of MeCP2-deficient neurons were observed during oxidant-mediated stress, hypoxia and mitochondrial inhibition. To further clarify the relevance of the fragile redox-balance for the neuronal (dys)function in RTT, we addressed more physiological stimuli and quantified the subcellular redox responses to neurotransmitter-stimulation. The roGFP redox sensor was expressed in either the cytosol or the mitochondrial matrix of cultured mouse hippocampal neurons, and the responses to transient stimulation by glutamate, serotonin, dopamine and norepinephrine were characterized. Each neurotransmitter evoked more intense oxidizing responses in the cytosol of MeCP2-deficient than in wildtype neurons. In the mitochondrial matrix the neurotransmitter-evoked oxidizing changes were more moderate and more uniform among genotypes. This identifies the cytosol as an important reactive oxygen species (ROS) source and as less stably redox buffered. Fura-2 imaging and extracellular Ca2+ withdrawal confirmed cytosolic Ca2+ transients as a contributing factor of neurotransmitter-induced redox responses and their potentiation in the cytosol of MeCP2-deficient neurons. Chemical uncoupling demonstrated the involvement of mitochondria. Nevertheless, cytosolic NADPH- and xanthine oxidases interact to play the leading role in the neurotransmitter-mediated oxidizing responses. As exaggerated redox-responses were already evident in neonatal MeCP2-deficient neurons, they may contribute remarkably to the altered neuronal network performance and the disturbed neuronal signaling, which are among the hallmarks of RTT.
Molecular Mechanisms to Target Cellular Senescence in Hepatocellular Carcinoma
Authors: Mittermeier Constanze , Konopa Andreas , Muehlich Susanne
Published: November 2020

Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death and is the most common type of liver cancer. Due to the current paucity of drugs for HCC therapy there is a pressing need to develop new therapeutic concepts. In recent years, the role of Serum Response Factor (SRF) and its coactivators, Myocardin-Related Transcription Factors A and B (MRTF-A and -B), in HCC formation and progression has received considerable attention. Targeting MRTFs results in HCC growth arrest provoked by oncogene-induced senescence. The induction of senescence acts as a tumor-suppressive mechanism and therefore gains consideration for pharmacological interventions in cancer therapy. In this article, we describe the key features and the functional role of senescence in light of the development of novel drug targets for HCC therapy with a focus on MRTFs.
ANT2-Mediated ATP Import into Mitochondria Protects against Hypoxia Lethal Injury
Authors: Gouriou Yves , Alam Muhammad , Harhous Zeina , Da Silva Claire , Baetz Delphine , Badawi Sally , Lefai Etienne , Rieusset Jennifer , Durand Annie , Harisseh Rania , Gharib Abdallah , Ovize Michel , Bidaux Gabriel
Published: November 2020

Following a prolonged exposure to hypoxia–reoxygenation, a partial disruption of the ER-mitochondria tethering by mitofusin 2 (MFN2) knock-down decreases the Ca2+ transfer between the two organelles limits mitochondrial Ca2+ overload and prevents the Ca2+-dependent opening of the mitochondrial permeability transition pore, i.e., limits cardiomyocyte cell death. The impact of the metabolic changes resulting from the alteration of this Ca2+crosstalk on the tolerance to hypoxia–reoxygenation injury remains partial and fragmented between different field of expertise. >In this study, we report that MFN2 loss of function results in a metabolic switch driven by major modifications in energy production by mitochondria. During hypoxia, mitochondria maintain their ATP concentration and, concomitantly, the inner membrane potential by importing cytosolic ATP into mitochondria through an overexpressed ANT2 protein and by decreasing the expression and activity of the ATP hydrolase via IF1. This adaptation further blunts the detrimental hyperpolarisation of the inner mitochondrial membrane (IMM) upon re-oxygenation. These metabolic changes play an important role to attenuate cell death during a prolonged hypoxia–reoxygenation challenge.
Production of Transparent Soda-Lime Glass from Rice Husk Containing Iron and Manganese Impurities
Authors: Gonçalves Jaderson , da Silva Gustavo , Lima Liandra , Morgado Daniella , Nalin Marcelo , Armas Luis E. G. , Valsecchi Chiara , Menezes Jacson W.
Published: November 2020

Glass is a familiar material that requires abundant mineral sources, with devastating consequences for the environment. Rice husk ash (RHA) presents a very high silica content (>95%) and it can be a very promising alternative source for silica in silica-based glass. However, impurities like manganese and iron, which depend on the rice harvest, might limit RHA use, particularly in the production of optical transparent glasses. In this work, we discussed how Mn and Fe can affect the coloring of the produced glass, and how the effect of these impurities can be removed. First, the RHA was treated with acid solutions, leading to the production of a soda-lime glass with similar transparency to commercial glass (>70%). Secondly, another simpler approach was studied: a small amount of antimony oxide was added in the composition of the glass, obtaining a transparent glass (>80%, same thickness) with RHA.
Optical, Electrochemical, Thermal, and Structural Properties of Synthesized Fluorene/Dibenzosilole-Benzothiadiazole Dicarboxylic Imide Alternating Organic Copolymers for Photovoltaic Applications
Authors: R. Murad Ary , Iraqi A. , Aziz Shujahadeen B. , N. Abdullah Sozan , Abdulwahid Rebar T. , Hussen Sarkawt A.
Published: November 2020

In this work, four donor–acceptor copolymers, PFDTBTDI-DMO, PFDTBTDI-8, PDBSDTBTDI-DMO, and PDBSDTBTDI-8, based on alternating 2,7-fluorene or 2,7-dibenzosilole flanked by thienyl units, as electron-donor moieties and benzothiadiazole dicarboxylic imide (BTDI) as electron-accepting units, have been designed and synthesized for photovoltaic applications. All polymers were synthesized in good yields via Suzuki polymerization. The impact of attaching two different alkyl chains (3,7-dimethyloctyl vs. n-octyl) to the BTDI units upon the solubilities, molecular weights, optical and electrochemical properties, and thermal and structural properties of the resulting polymers was investigated. PFDTBTDI-8 has the highest number average molecular weight (Mn = 24,900 g·mol−1) among all polymers prepared. Dibenzosilole-based polymers have slightly lower optical band gaps relative to their fluorene-based analogues. All polymers displayed deep-lying HOMO levels. Their HOMO energy levels are unaffected by the nature of either the alkyl substituents or the donor moieties. Similarly, the LUMO levels are almost identical for all polymers. All polymers exhibit excellent thermal stability with Td exceeding 350 °C. X-ray powder diffraction (XRD) studies have shown that all polymers have an amorphous nature in the solid state.
Design, Development and Validation of a Portable Gas Sensor Module: A Facile Approach for Monitoring Greenhouse Gases
Authors: Mane Supriya A. , Nadargi Digambar Y. , Nadargi Jyoti D. , Aldossary Omar M. , S. Tamboli Mohaseen , Dhulap Vinayak P.
Published: November 2020

We report the unique design and prototype of a portable gas sensor module for monitoring greenhouse gases. The commercially available gas sensors (MQ-02, MQ-135, and TGS2602) were adopted in designing the module using Arduino Uno. Different locations in the city of Solapur, India (17.6599° N, 75.9064° E), were scanned for the usability of the developed prototype of the mobile gas sensor module. The choice of gas sensors in combination with Arduino Uno led to an excellent prototype for measuring the concentration of greenhouse gases, and therefore the wrong alarm for toxic gases. The prototype model and corresponding greenhouse gas concentrations (ppm) are described using an interplay of sensor design, software program, and greenhouse gases sites.
Recent Advances in Graphene Oxide-Based Anticorrosive Coatings: An Overview
Authors: Necolau Mădălina-Ioana , Pandele Andreea-Mădălina
Published: November 2020

The present review outlines the most recent advance in the field of anticorrosive coatings based on graphene oxide nanostructures as active filler. This carbonaceous material was extensively used in the last few years due to its remarkable assets and proved to have a significant contribution to composite materials. Concerning the graphene-based coatings, the synthesis methods, protective function, anticorrosion mechanism, feasible problems, and some methods to improve the overall properties were highlighted. Regarding the contribution of the nanostructure used to improve the capability of the material, several modification strategies for graphene oxide along with the synergistic effect exhibited when functionalized with other compounds were mainly discussed.
Wind Inertial Response Based on the Center of Inertia Frequency of a Control Area
Authors: Mujcinagic Alija , Kusljugic Mirza , Nukic Emir
Published: November 2020

As a result of the increased integration of power converter-connected variable speed wind generators (VSWG), which do not provide rotational inertia, concerns about the frequency stability of interconnected power systems permanently arise. If the inertia of a power system is insufficient, wind power plants’ participation in the inertial response should be required. A trendy solution for the frequency stability improvement in low inertia systems is based on utilizing so-called “synthetic” or “virtual” inertia from modern VSWG. This paper presents a control scheme for the virtual inertia response of wind power plants based on the center of inertia (COI) frequency of a control area. The PSS/E user written wind inertial controller based on COI frequency is developed using FORTRAN. The efficiency of the controller is tested and applied to the real interconnected power system of Southeast Europe. The performed simulations show certain conceptual advantages of the proposed controller in comparison to traditional schemes that use the local frequency to trigger the wind inertial response. The frequency response metrics, COI frequency calculation and graphical plots are obtained using Python.
Reversible Heat Pump Coupled with Ground Ice Storage for Annual Air Conditioning: An Energy Analysis
Authors: Mancin Simone , Noro Marco
Published: November 2020

During annual operation, a heat pump produces both heating and cooling effects, so it would be of great advantage to store one of the two to be then used when it is necessary. To do this, a seasonal energy storage is necessary. This paper presents results relative to the use of a ground ice thermal energy storage (I-TES) integrated with a reversible heat pump for annual air conditioning. The energy analysis is based on heating and cooling loads for a residential building located in Milan. In particular, the focus is on the most important parameters affecting the performance of both the whole system and the Ice Tank, which is the position and the thickness of the insulation layers and the shape of the ice tank. A biannual simulation of the system allows for a full description of the ice tank behavior during the charging and discharging processes. The main objective of the study is to suggest a first tentative procedure to design the I-TES integrated system with the best energy performance.
Performance Review of Three Car Integrated ABS Types: Development of a Tire Independent Wheel Speed Control
Authors: Montani Margherita , Vitaliti Daniele , Capitani Renzo , Annicchiarico Claudio
Published: November 2020

This study concerns the development and testing of three types of Anti-lock Brake Systems (ABS): a standard on-off wheel’s acceleration control; a wheel’s longitudinal slip controller based on a discrete Proportional-Integral-Derivative (PID) control; and a novel type of ABS that involves controlling the wheel’s speed through a discrete PID. This work was developed inside a wider project that will lead to the implementation of stability control systems in a prototype car. For this reason, the typologies of ABS must not require extra sensors compared to those in standard vehicles: Inertial Measurement Unit (IMU) and 4-wheel speed sensors. Furthermore, they must be easily integrated with other controls and electronic components in terms of sampling time and values. The standard ABS seems more appropriate than the others two because it uses only parameters defined by sensors and it has a simple architecture that does not have the problem of computational time. However, in recent years, cars have been equipped with Electro-Hydraulic-Braking (EHB) units that improve the performance of the system controls. In fact, it is possible to use a control that allows actuators to follow a continuous target and smooth out pressure actions. Even if the longitudinal Slip Controller has a simple architecture and uses a PID control, it is limited to using quantities estimated instead of measured: the tires’ friction coefficient, the tires’ longitudinal stiffness, and the car’s speed. Therefore, the use of a Wheel Speed Controller is the right compromise to link the advantages of both controllers by following the braking pressure continuously and not needing to know the condition and properties of the tires. The results of tests carried out in a Hardware-In-the-Loop (HiL) system are showed and involved a complex vehicle model implemented in real-time.
A Novel Equivalent Continuum Approach for Modelling Hydraulic Fractures
Authors: Atdayev Eziz , Wong Ron C. K. , Eaton David W.
Published: November 2020

Hydraulic fracturing has transitioned into widespread use over the last few decades. There are a variety of numerical methods available to simulate hydraulic fracturing. However, most current methods require a large number of input parameters, of which the values of some parameters are poorly constrained. This paper proposes a new method of modelling the hydraulically fractured region using void-ratio dependent relation to define the permeability of the fractured region. This approach is computationally efficient and reduces the number of input parameters. By implementing this method with an equivalent continuum representation, uncertainties are reduced arising from heterogeneity and anisotropy of earth materials. The computational efficiency improves modelling performance in stress sensitive zones such as in the vicinity of the injection well or near faults.
In Situ Monitoring of Drying Process of Masonry Walls
Authors: Cieślikiewicz Łukasz , Łapka Piotr , Mirowski Radosław
Published: November 2020

The in situ hygro-thermal behavior of a wet masonry wall during its drying process is presented in this paper. The considered wall is a part of a basement of a historic building that was subjected to renovation works. The building is located in the City of Łowicz (Poland). The drying process was implemented by applying the thermo-injection method and a novel prototype of the drying device used for this method. The dedicated acquisition system was developed to in situ monitor parameters of the drying process. The air temperature and relative humidity in various locations in the basement, temperatures and moisture contents at several points of the wet wall as well as the electrical parameters of the drying device were registered. Based on variations of the monitored parameters, the hygro-thermal behavior of the wall during drying was studied. After 6 days of drying, the wall temperature in the drying zone was increased to approximately 40–55 °C, while the moisture content was reduced to the mean level of 3.76% vol. (2.35% wt.). These wall parameters allowed for effective impregnation of the wall with the hydrophobic silicone micro-emulsion, which created horizontal and vertical waterproofing. Moreover, the specific energy consumption during the drying process defined as energy consumption divided by the mean volumetric moisture content drop (MC) between the initial and final state in the wall and by the length of the dried wall section was estimated to be 11.08 kWh/MC%/m.
Towards a Standard Framework to Identify Green Infrastructure Key Elements in Dense Mediterranean Cities
Authors: Delgado-Capel Manuel , Cariñanos Paloma
Published: November 2020

Present-day dense cities are increasingly affected by the impacts associated with climate change. The recurrence of extreme climate events is projected to be intensified in cities in the next decades, especially in the most vulnerable areas of the world, such as the Mediterranean region. In this context, the urban green infrastructure (UGI) is presented as a nature-based solution that directly contributes to climate change mitigation in Mediterranean compact cities and improves health, social, welfare, and environmental conditions for inhabitants. This research sets out a manageable framework to define, locate, and categorize more functional green urban and peri-urban areas in a dense Mediterranean city. It takes spatial distribution, extension, and the capacity to improve inhabitants’ wellbeing through the provision of ecosystem services as classification criteria. Results show a scenario with a greater functional green surface available for the citizens to be managed. Identified areas have been categorized as cores, nodes, links, and green spaces defined as “other” areas. In particular, the latter play a significant role at social, structural, and ecological levels. The study showcases that rethinking urban design and strategic decision-making around these areas can enhance green equity in Mediterranean dense cities, their capacity to better deal with environmental extremes, and the inhabitants’ engagement with a culture of sustainability and wellbeing.
Evaluation of the Ion AmpliSeq™ PhenoTrivium Panel: MPS-Based Assay for Ancestry and Phenotype Predictions Challenged by Casework Samples
Authors: Diepenbroek Marta , Bayer Birgit , Schwender Kristina , Schiller Roberta , Lim Jessica , Lagacé Robert , Anslinger Katja
Published: November 2020

As the field of forensic DNA analysis has started to transition from genetics to genomics, new methods to aid in crime scene investigations have arisen. The development of informative single nucleotide polymorphism (SNP) markers has led the forensic community to question if DNA can be a reliable “eye-witness” and whether the data it provides can shed light on unknown perpetrators. We have developed an assay called the Ion AmpliSeq™ PhenoTrivium Panel, which combines three groups of markers: 41 phenotype- and 163 ancestry-informative autosomal SNPs together with 120 lineage-specific Y-SNPs. Here, we report the results of testing the assay’s sensitivity and the predictions obtained for known reference samples. Moreover, we present the outcome of a blind study performed on real casework samples in order to understand the value and reliability of the information that would be provided to police investigators. Furthermore, we evaluated the accuracy of admixture prediction in Converge™ Software. The results show the panel to be a robust and sensitive assay which can be used to analyze casework samples. We conclude that the combination of the obtained predictions of phenotype, biogeographical ancestry, and male lineage can serve as a potential lead in challenging police investigations such as cold cases or cases with no suspect.
Clinical Characteristics of Suicidal Youths and Adults: A One-Year Retrospective Study
Authors: Besch Vincent , Greiner Christian , Magnin Charline , Néris Mélanie De , Ambrosetti Julia , Perroud Nader , Poulet Emmanuel , Debbané Martin , Prada Paco
Published: November 2020

Suicide is a major mental health problem, particularly during youth, when it is the second leading cause of death. Since young people at risk of suicide are often cared for by the adult health system, we sought to identify the specificities and similarities between suicidal youths and adults in order to further inform the potential need for adaptations in taking care of suicidal youths. For this study, we used the following data: mental disorders, treatments, previous hospitalization, and reasons for current hospitalization, that were collected from November 2016 to October 2017 among people hospitalized for a suicidal crisis in a specialized psychiatric unit. First, we compared the data from the youth group with those from the adult group, and then we tried to determine if there were any associations between variables. Analyses showed that youths were more similar to adults than expected. In particular, we found comparable rates of personality disorders (especially borderline) and relapse, and similar profiles of reasons for hospitalization in suicidal crisis. Remarkably, among youth, neuroleptics appeared to be associated with fewer hospitalizations for behavioral than ideational reasons, but with more relapses. Results of this study suggest that young people could benefit from brief psychotherapeutic interventions implemented for adults.
Myths about Sexual Aggression, Sexual Assertiveness and Sexual Violence in Adolescent Romantic Relationships
Authors: Fernández-Fuertes Andrés A. , Fernández-Rouco Noelia , Lázaro-Visa Susana , Gómez-Pérez Eva
Published: November 2020

Sexual violence is a worldwide health and social issue. However, little is known about the sexual violence that occurs in the context of romantic relationships. This study analyzes the existence of sexual violence in adolescents’ romantic relationships, the possible associations between such violence (both committed and suffered) and myths about sexual aggression and sexual assertiveness, and the possible gender-related distinctions. A sample of 329 students aged between 15 and 19 (M = 16.3; SD = 0.79) was surveyed; all participants were in a romantic relationship when the data were collected. The results reveal that both genders report the existence of sexual violence in their romantic relationships; however, in heterosexual relationships, males were more often the perpetrators of sexual violence. Additionally, myths about sexual aggression and sexual assertiveness were found to be significantly associated with both perpetration and victimization. Accordingly, these predictors should be focal points in prevention programs for adolescent sexual violence. The findings of this study show the de-prioritization of sexuality education in the Spanish educational system, as well as the need to strengthen the competence of adolescents in this area.
Compulsive Internet and Prevalence Substance Use among Spanish Adolescents
Authors: Fernández-Aliseda Sonia , Belzunegui-Eraso Angel , Pastor-Gosálbez Inma , Valls-Fonayet Francesc
Published: November 2020

This paper analyses compulsive Internet use among Spanish adolescents as measured by the Compulsive Internet Use Scale (CIUS) of the ESTUDES 2016 survey (national survey on drug use in secondary schools), which was recently added to the statistical programme of the Spanish National Plan on Drugs. We examined two subsamples of Spanish adolescents (those who suffer from compulsive Internet use and those who do not) while taking into account gender and age. Our general hypothesis was that adolescents who suffer from compulsive Internet use have a greater prevalence of alcohol, tobacco, cannabis, sedative, and new substance consumption as well as a greater prevalence of modes of consumption such as getting drunk, drinking with friends in public places (botellón), and binge drinking. While our results confirm these assumptions, they also suggest that gender and age play an ambivalent role in these associations.
Effectiveness of Psychological Capital Intervention and Its Influence on Work-Related Attitudes: Daily Online Self-Learning Method and Randomized Controlled Trial Design
Authors: Da Shu , He Yue , Zhang Xichao
Published: November 2020

Research on positive psychology intervention is in its infancy; only a few empirical studies have proved the effectiveness and benefits of psychological capital interventions in workplaces. From a practical perspective, a more convenient intervention approach is needed for when organizations have difficulties in finding qualified trainers. This study aims to extend the psychological capital intervention (PCI) model and examine its influence on work-related attitudes. A daily online self-learning approach and a randomized controlled trial design are utilized. A final sample of 104 full-time employees, recruited online, is randomly divided into three groups to fill in self-report questionnaires immediately before (T1), immediately after (T2), and one week after (T3) the intervention. The results indicate that the intervention is effective at improving psychological capital (PsyCap), increasing job satisfaction, and reducing turnover intention. The practical implications for human resource managers conducting a flexible and low-cost PsyCap intervention in organizations are discussed. Limitations related to sample characteristics, short duration effect, small sample size, and small effect size are also emphasized. Due to these non-negligible drawbacks of the study design, this study should only be considered as a pilot study of daily online self-learning PsyCap intervention research.
An Integrative Review of How Healthcare Organizations Can Support Hospital Nurses to Thrive at Work
Authors: Moloney Willoughby , Fieldes Jessica , Jacobs Stephen
Published: November 2020

Background: Solutions that address the anticipated nursing shortage should focus on thriving at work: a positive psychological state characterized by a sense of vitality and learning, resulting in higher levels of work engagement, commitment, and wellbeing. Purpose: To synthesize international evidence on organizational factors that support hospital nurse wellbeing and to identify how the Social Embeddedness of Thriving at Work Model can support health managers to develop management approaches that enable nurses to thrive. Method: Conduct an integrative review of literature published between 2005–2019. Results: Thematic analysis identified five key themes: (1) Empowerment; (2) Mood of the organization; (3) An enabling environment; (4) Togetherness with colleagues; and (5) Leaders’ connectivity. Conclusions: The Social Embeddedness of Thriving at Work Model supports managers to develop management approaches that enable their nurses to thrive. Health managers should consider strategies to support nurses to thrive at work to improve nurse work engagement and wellbeing.
Changes of Coenzyme A and Acetyl-Coenzyme A Concentrations in Rats after a Single-Dose Intraperitoneal Injection of Hepatotoxic Thioacetamide Are Not Consistent with Rapid Recovery
Authors: Shurubor Yevgeniya I. , Cooper Arthur J. L. , Krasnikov Andrey B. , Isakova Elena P. , Deryabina Yulia I. , Beal M. Flint , Krasnikov Boris F.
Published: November 2020

Small biomolecules, such as coenzyme A (CoA) and acetyl coenzyme A (acetyl-CoA), play vital roles in the regulation of cellular energy metabolism. In this paper, we evaluated the delayed effect of the potent hepatotoxin thioacetamide (TAA) on the concentrations of CoA and acetyl-CoA in plasma and in different rat tissues. Administration of TAA negatively affects liver function and leads to the development of hepatic encephalopathy (HE). In our experiments, rats were administered a single intraperitoneal injection of TAA at doses of 200, 400, or 600 mg/kg. Plasma, liver, kidney, and brain samples were collected six days after the TAA administration, a period that has been suggested to allow for restoration of liver function. The concentrations of CoA and acetyl-CoA in the group of rats exposed to different doses of TAA were compared to those observed in healthy rats. The results obtained indicate that even a single administration of TAA to rats is sufficient to alter the physiological balance of CoA and acetyl-CoA in the plasma and tissues of rats for an extended period of time. The initial concentrations of CoA and acetyl-CoA were not restored even after the completion of the liver regeneration process.