bluuebunny/crossref_metadata_2025 huggingface dataset:
An anti-aging dietary supplement inhibits dipeptidyl peptidase-4 (DPP-4) and arginase in vitro and improves quality of life factors of middle-aged adults
Authors: West Brett , Swartz Fernando
Published: April 2022

Somatopause is the progressive and age-related decline of growth hormone (GH) production due to changes in hypothalamic-pituitary axis signaling and results in typical physiological changes associated with the aging process. Dipeptidyl peptidase-4 (DPP-4) influences hypothalamic-pituitary axis signaling and reduces GH production and secretion. Since DPP-4 concentrations increase with age, we investigated the anti-aging potential of several botanical ingredients, including noni fruit juice, by evaluating their abilities to inhibit this enzyme in vitro. We discovered that a blend of these botanical ingredients synergistically inhibited DPP-4 by up to approximately 99%. We subsequently formulated an anti-aging dietary supplement with this blend of botanical ingredients by adding amino acids (L-arginine, L-Lysine, citrulline and beta-alanine), gamma-aminobutyric acid (GABA), flax seed oil and several nutrients. The supplement was evaluated for anti-arginase activity in vitro, as the expression of this enzyme also increases with age. A concentration-dependent reduction in arginase activity was observed. The dietary supplement was also provided to three men and one woman, ages 56 to 62, with relevant but disparate medical histories. Following short-term ingestion of the supplement, these volunteers were interviewed to ascertain any changes in health status. All reported positive improvements in at least one quality of life factor, which included more restful sleep, reduced musculoskeletal discomfort, increased energy, improved physical stamina and better skin quality. These initial findings suggest that the anti-aging dietary supplement can mitigate declines in quality of life associated with aging by reducing DPP-4 and arginase activities, thereby supporting healthy GH production and endothelial nitric oxide production.
Thermophysical Properties of Solutions of Iron(III) Nitrate Nonahydrate in Mixtures of 1-Propanol and Water
Authors: Keller Alexander , Wlokas Irenäus , Kohns Maximilian , Hasse Hans
Published: April 2022

The simulation of spray flame processes for the production of high-quality nanoparticles relies on thermophysical properties of the precursor solutions, for which literature data are scarce. Here, we report experimental thermophysical data of solutions of iron(III) nitrate nonahydrate (INN) in (1-propanol + water) mixed solvents. The specific density, viscosity, thermal conductivity, and isobaric heat capacity of the solutions were measured at 101.3 kPa between 288.15 and 333.15 K, solvent compositions ranging from 0.73 mol mol–1 1-propanol to pure water, and INN molalities up to 1.3 mol kg–1. Empirical correlations of the experimental data are provided.
Predicting Activity Coefficients at Infinite Dilution for Varying Temperatures by Matrix Completion
Authors: Damay Julie , Jirasek Fabian , Kloft Marius , Bortz Michael , Hasse Hans
Published: April 2022

Activity coefficients describe the nonideality of liquid mixtures and are essential for calculating equilibria. The activity coefficients at infinite dilution in binary mixtures are particularly important as the activity coefficients at finite concentrations can be predicted based on their knowledge not only in binary mixtures but also in multicomponent mixtures. The available experimental data on these activity coefficients at infinite dilution in binary mixtures is readily accessible in databases and can be organized in a matrix with the rows representing the solutes and the columns representing the solvents or vice versa. As experimental data is lacking for many binary mixtures, this matrix is only sparsely populated. Filling its gaps using predictive methods is essential. Recently, matrix completion methods (MCMs) have been applied successfully for this purpose. However, only isothermal data sets have been considered. In the present work, we apply an MCM to predict activity coefficients at infinite dilution at varying temperatures. Furthermore, we show how one can incorporate physical knowledge on the nature of the temperature dependency of the activity coefficients at infinite dilution. The predictions obtained with this new approach outperform those obtained with the best currently available physical prediction method for activity coefficients at infinite dilution, the modified UNIFAC (Dortmund) method.
Influence of pH Value and Salts on the Adsorption of Lysozyme in Mixed-Mode Chromatography
Authors: Kreußer Jannette , Jirasek Fabian , Hasse Hans
Published: April 2022

Mixed-mode chromatography (MMC) is an interesting technique for challenging protein separation processes which typically combines adsorption mechanisms of ion exchange (IEC) and hydrophobic interaction chromatography (HIC). Adsorption equilibria in MMC depend on multiple parameters but systematic studies on their influence are scarce. In the present work, the influence of the pH value and ionic strengths up to 3000 mM of four technically relevant salts (sodium chloride, sodium sulfate, ammonium chloride, and ammonium sulfate) on the lysozyme adsorption on the mixed-mode resin Toyopearl MX-Trp-650M was studied systematically at 25℃. Equilibrium adsorption isotherms at pH 5.0 and 6.0 were measured and compared to experimental data at pH 7.0 from previous work. For all pH values, an exponential decay of the lysozyme loading with increasing ionic strength was observed. The influence of the pH value was found to depend significantly on the ionic strength with the strongest influence at low ionic strengths where increasing pH values lead to decreasing lysozyme loadings. Furthermore, a mathematical model that describes the influence of salts and the pH value on the adsorption of lysozyme in MMC is presented. The model enables predicting adsorption isotherms of lysozyme on Toyopearl MX-Trp-650M for a broad range of technically relevant conditions.
Resume Ekonomi mikro_Rezky Kurniati Rusli 042
Authors: Rusli Rezky Kurniati
Published: April 2022

Asal kata ekonomi dari bahasa Yunani: oikos (rumah tangga) dan Nomos (pengaturan)
Modeling and Monitoring the Development of an Oil Field under Conditions of Mass Hydraulic Fracturing
Authors: M Hofmann , Al-Obaidi Sudad H , FH Khalaf
Published: April 2022

In order to ensure the most complete recovery of hydrocarbons and to minimize costs in the production process, it is necessary to control the development of an oil field, even during production, through various geological and technological measures. In terms of the volume of additional oil extracted through the implementation of geological and technological measures, hydraulic fracturing (HF) operations occupy the top positions. This paper describes a modified method for accounting for hydraulic fractures in a geological and technological model of a hydrocarbon field. The method makes it possible to perform all calculations related to the modeling of fractures in the pre-processing phase and to use its results as input data for the hydrodynamic simulator. An example of the calculation on a real development object is given. The analysis of the results showed the correctness of this method. The geological and hydrodynamic model provided a satisfactory reproduction of the development history for the oil field under study. The predicted flow rates and bottomhole pressures of the wells were close to the actual values. The error in annual oil and fluid rates is no greater than 3 %. The results of the calculations can serve as indirect confirmation of the hypothesis of spontaneous growth of hydraulic fracturing cracks in injection wells. In fact, by increasing the half-length of the hydraulic fractures in the injection wells in the model to 250 m, the discrepancy between the calculated and actual bottomhole pressures was reduced to fractions of a percent. The half-length of the fracture was 70 - 140 m and the half-opening was 1.2 - 2.5 mm. The average permeability of the proppant package in the crack is 220 d. The calculated skin factor for the design wells according to the proposed model was −4.58.
Thermophysical Properties of Mixtures of Titanium(IV) Isopropoxide (TTIP) and 2-Propanol (iPOH)
Authors: Keller Alexander , Wlokas Irenäus , Kohns Maximilian , Hasse Hans
Published: April 2022

The present work provides thermophysical data on binary mixtures of titanium(IV) isopropoxide (TTIP) and 2-propanol (iPOH), which are important precursor solutions in spray flame synthesis of nanoparticles. The specific density, viscosity, thermal conductivity, and molar isobaric heat capacity were measured at 101.3 kPa and temperatures ranging from 293.15 to 333.15 K. The vapor–liquid equilibrium (VLE) was measured at pressures ranging from 20 to 80 kPa. Furthermore, self-diffusion coefficients of pure iPOH were measured at 101.3 kPa and temperatures ranging from 293.15 to 333.15 K. A qualitative study using 1H NMR spectroscopy provides evidence for a cross-association between TTIP and iPOH in the mixture. Correlations for all studied thermophysical properties are provided. The results establish a rational basis for the design of spray flame synthesis processes.
Manajemen Koperasi
Authors: Iskandar Isda
Published: April 2022

Manajemen Koperasi diselenggarakan oleh orang-orang yang bertanggung jawab untuk mengelolah koperasi, nilai-nilai dan kekayaannya.
Perkembangan dan Peranan Bank Syariah Di Indonesia
Authors: Muhajir
Published: April 2022

Perbankan di Indonesia kini makin diramaikan dengan adanya bank syariah, yang menawarkan produk keuangan dan investasi dengan cara yang berbeda dibanding bank konvensional yang sudah lama ada. Bahkan bank-bank konvensional di Indonesia kini ikutan tren dengan mendirikan institusi syariah atau unit usaha syariah sendiri Lahirnya bank syariah tersebut merupakan cikal bakal dari terbentuknya Lembaga Keuangan Syariah (LKS) di Indonesia pada tahun 1980-an. Indonesia yang merupakan salah satu negara berkembang senantiasa melakukanberbagai aktivitas ekonomi untuk mendukung keberlanjutan pembangunan nasional secara kontinu.Di mana membangun kawasan keuangan berbasis syariah yang kuat dan terintegrasi maka diperlukan adanya kerja sama di antara pihak-pihak yang terkait. Dan yang menjadi syarat terpenting adanya integrasi keuangan syariah adalah terjadinya harmonisasi regulasi di antara Negara yang bersangkutan.
Lucretius’ On the Nature of Things
Authors: Ajvazi Irfan
Published: April 2022

Lucretius On the Nature of Things draws heavily on Epicurus’s ideas, translating them from Greek into Latin and putting them into his own poetic voice. It is therefore the best source we have for the ideas of [classical Epicurean philosophy]. The atomic model is not more than a representational model of the physical universe up to a certain level of magnification. Modern science dives much deeper than atoms and ends up with no matter at all.
Speciation in CO2-loaded Aqueous Solutions of Sixteen Triacetoneamine-derivates (EvAs) and Elucidation of Structure-property Relationships
Authors: Kessler Elmar , Ninni Luciana , Breug-Nissen Tanja , Willy Benjamin , Schneider Rolf , Irfan Muhammad , Rolker Jörn , Thiel Werner R. , von Harbou Erik , Hasse Hans
Published: April 2022

The speciation in CO2-loaded aqueous solutions of 16 different derivates of triacetoneamine (EvAs) was investigated in a comprehensive NMR-spectroscopic study. About 350 experiments were carried out for CO2-loadings up to 3 moles CO2 per mole amine, temperatures between 20 °C and 100 °C, and a mass fraction of EvA in the unloaded solvent of 0.1 g/g. The observed CO2-containing species were primary and secondary carbamates, alkylcarbonate, (bi)carbonate, and molecular CO2. Some EvAs can form zwitterions with a ring structure, which have an important influence on the speciation. From the comprehensive set of data, relationships between the chemical structure of the EvAs and the observed speciation in aqueous solution were established. These results were related to application properties of the EvAs that were taken from previous work. Based on the findings, some general guidelines for the design of new amines were derived and applied for proposing new amines for CO2-absorption.
Antifertility: Its Ethnopharmacological Advancement
Authors: Bhattacharya Arghya , Bhattacharjee Soumik , Nandi Sumit , Junior Romeu Felix Menin , Sabui Rajashree , Roy Sudip , Dhara Bikram , Mukherjee Dattatreya
Published: April 2022

Medicinal plants are a popular term that everyone can use to describe plants that are useful intreating a variety of conditions that are not treatable by allopathic treatment. Among these, birthcontrol and, at the same time, growing human fertility have both become serious issues in recentyears. This review provides up-to-date information on medicinal plants that have beenscientifically proven to have anti-fertility properties. The botanical name, family, parts used, andchemical elements present in plants are all included in this study. Despite the fast advancementand dissemination of modern medicine and surgery, traditional practices retain their appeal andconfidence. Traditional herbal treatments have been shown to have anti-fertility effects innumerous research.The purpose of this review is to highlight research on plant-based antifertility. This article may aid researchers in identifying therapeutic herbs that have anti-fertilityproperties.
Buku USBN PAI SMP/MTS Tahun 2019
Authors: Qosim Nanang
Published: April 2022

Buku USBN PAI SMP/MTS Tahun 2019
MANAJEMEN KEUANGAN
Authors: Indi  , Nasrullah Andhini putri novianti , Rasyid Andi Syahrul Ramadhan , Yusmiana Gusti , Puspitasari Ayu , Alimin Fahira
Published: April 2022

Koperasi merupakan organisasi otonom dari orang-orang yang berhimpun budaya secara bersama-sama melalui kegiatan usaha yang dimiliki dan dikendalikan secara demokratis. Melalui koperasi ini masyarakat bisa memulai usaha dengan cara meminjam modal ke koperasi yang dimiliki oleh masyarakat tersebut.
Multicriteria Optimization of Molecular Models of Water Using a Reduced Units Approach
Authors: Kulkarni Aditya , Bortz Michael , Küfer Karl-Heinz , Kohns Maximilian , Hasse Hans
Published: April 2022

Multicriteria optimization (MCO) is used to parametrize molecular models of water. The set of the best possible compromises between different objectives, the Pareto set, is determined. Calculating Pareto sets for optimization problems involving molecular simulations is computationally expensive. Therefore, we use a novel, highly efficient method, which is based on the fact that numerical results from molecular simulations can be interpreted as dimensionless numbers. Hence, they carry information on an entire class of models in physical units. This approach was applied here for the MCO of water models of the “one-center Lennard-Jones + point charge” type, in which the objectives were the quality of the description of the vapor pressure, liquid density, and enthalpy of vaporization. The results were compared to models from the literature. Significant improvements were observed. The new optimization method for the development of molecular models is efficient, robust, and broadly applicable.
How can I integrate iEEG recordings with patients’ brain anatomy?
Authors: Sadhukha Sushmita , Oostenveld Robert , Stolk Arjen
Published: April 2022

Preparing intracranial electroencephalography (iEEG) datasets for analysis presents a unique set of methodological challenges that are absent in non-invasive investigative techniques. Because iEEG is primarily used in epilepsy patients with varying brain pathologies, the main challenges pertain to variability in electrode coverage and therefore the regions of the brain from which electrophysiological recordings can be obtained. In this chapter, we outline how to efficiently integrate the raw anatomical images and electrophysiological recordings during preprocessing, allowing iEEG datasets to be analyzed in an anatomically precise and consistent way.
Computational Underpinnings of Partisan Information Processing Biases and Associations with Depth of Cognitive Reasoning
Authors: Derreumaux Yrian , Shamsian Kimia , Hughes Brent
Published: April 2022

Despite unprecedented access to information, partisans increasingly disagree about basic facts that are backed by data, posing a serious threat to a democracy that relies on finding common ground based on objective truths. We examine the underpinnings of this phenomenon using drift diffusion modeling (DDM). Partisans (N=148) completed a sequential sampling task where they evaluated the honesty of Democrat or Republican politicians during a debate based on fact-check scores. We found that partisans required less and weaker evidence to correctly categorize the ingroup as more honest, and were more accurate on trials when the ingroup candidate was more honest, compared to the outgroup. DDM revealed that such tendencies arise from both a prior preference for categorizing the ingroup as more honest (i.e., biased starting point) and more precise accumulation of information favoring the ingroup candidate compared to the outgroup (i.e., biased drift rate). Moreover, individual differences in cognitive reasoning moderated task performance for the most devoted partisans and maintained divergent associations with the DDM parameters. This suggests that partisans may reach biased conclusions via different pathways depending on their depth of cognitive reasoning. These findings provide key insights into the mechanisms driving partisan divides in polarized environments, and can inform interventions that reduce impasse and conflict.
Conducta Virtual | Marco de referencia para el diseño de conductas virtuales en el metaverso
Authors: León-Domínguez Umberto
Published: April 2022

En la actualidad, una nueva realidad como el metaverso está emergiendo con infinitas posibilidades de interacción. Estos espacios virtuales son nuevos entornos donde diferentes personas, en su forma de avatar, se comportarán e interaccionarán con otros avatares y elementos virtuales. Esta nueva realidad es una proyección que ocurre en la mente de los usuarios, por lo que las conductas que tienen que ocurrir siguen unas leyes comportamentales ampliamente estudiadas por la psicología. De esta manera, el presente trabajo monográfico recopila un cuerpo de conocimiento científico proveniente del análisis psicológico y comportamental de los usuarios y jugadores de mundos virtuales, y que podría ayudar al diseño del metaverso y de sus infinitos espacios virtuales. Este monográfico articula dicho conocimiento en un marco de referencia que pueda ser consultado por diferentes psicólogos, fomentando un diseño de escenarios virtuales para que las conductas de los avatares puedan ocurrir de forma óptima y ergonómica.
Biased self-other attribution changes feedback control: link between the sense of agency and sensorimotor control
Authors: Tanaka Masaru , Ohata Ryu , Asai Tomohisa , Imamizu Hiroshi
Published: April 2022

Agents must correctly attribute the source of sensory inputs to the self or other for successful interaction with the environment. Many previous research works have revealed that self-other attribution depends on the discrepancy between sensory prediction and actual sensory feedback (sensory prediction error). Self-other attribution is assumed to determine how agents reflect sensory feedback in their feedback control. However, the direct effect of self-other attribution on feedback control is still unclear. In the current study, participants’ self-other attribution was biased through induction training in the selfward or otherward direction at a cognitive-judgment level. Before and after the induction, participants controlled a morphed cursor between self and other movements and evaluated the self-other attribution of the cursor movement. We first confirmed that the induction biased their self-other attributions toward the intended direction (i.e., selfward or otherward). Next, we examined whether the respective bias changed the feedback control of the cursor. For the self-biased group, the more participants attributed their visual feedback to themselves, the more they tried to control the morphed cursor in a specific condition. In contrast, for the other-biased group, the more participants attributed their visual feedback to others, the less they tried to control the morphed visual feedback in a specific condition. These results suggest that self-other attribution is not simply a cognitive process reflecting the sensory feedback of motor control but also a factor affecting motor control in a top-down manner.
Who believes in conspiracy theories? A meta-analysis on personality correlates
Authors: Stasielowicz Lukasz
Published: April 2022

Conspiracy theories are ubiquitous (e.g., 9/11, COVID-19) and can have negativeconsequences (e.g., prejudice). Thus, there is an increasing need for evidence-basedrecommendations (e.g. possible target groups) with respect to interventions andprevention measures. Present Bayesian three-level meta-analysis (686 correlations,127 independent samples) includes a synthesis of the extant literature with respect to12 personality correlates and their relationship with conspiracy beliefs. On average,people who believe in pseudoscience, suffer from paranoia or schizotypy, arenarcissistic or religious/spiritual and have relatively low cognitive ability, are more likelyto believe in conspiracy theories. Heterogeneity was partially explained by theexamined moderators and no strong evidence for publication bias was found.Implications for developing tailored interventions are discussed in the article.
Wandering Dervish of Laila Majnu: Sufism and Socio-Political Mobilization in Kashmir
Authors: Ahad Waseem , Akgül Selma
Published: April 2022

Historically Sufism has been portrayed as an acceptable mode of Islam in Bollywood and political Islam as a threat to Indian secular ethos. This has been particularly true of Kashmir films. However, Bollywood’s emphasis on the syncretic dimension of Sufism is a misappropriation of Kashmir’s Islamic history. This study establishes that Kashmir’s Sufism has to be seen as a socio-political movement that has been instrumental in liberating the lower caste Kashmiris from the Brahminic hegemony. Also, Islamization in Kashmir has to be seen as a historical evolution of a community, rather than a transition from one set of beliefs to another. The syncretization of Hinduism and Islam in Hindi cinema is an assertion of the postcolonial nationalist imagination of a secular India. This assertion is a product of the anxieties of loss of the territory with which the nation shares a turbulent relationship. Sufism conceived of in this way becomes instrumental in ideological co-optation of the Muslim-majority Kashmir. The study probes Laila Majnu’s (2018) wandering dervish protagonist to chart out the representation of “individualistic” and “renunciatory” dimension of Sufism that couches Orientalist notions of the primitive and repressive “Muslim mind”. The apolitical narrative of the film mandates a critical inquiry since it is set amidst the politically charged atmosphere of Kashmir.
Education of rabbit cultivators on the use of drug with the right dosage for preventing resistance
Authors: Hamid Penny Humaidah , Widayati Rini , Nugroho Widagdo Sri , Prastowo Sigit , Raharjo Slamet
Published: April 2022

Because of its dual purpose as livestock and pets, rabbit farming offers a number of advantages. Rabbit meat is of high quality, both in terms of taste and nutritional value. The purpose of this service activity is to provide farmers a hands-on understanding of how important it is to treat rabbit diseases at the proper dose. Veterinary care operations for 200 sick rabbits were used to educate the public. The activity continued with a dialogue about health issues in rabbit farming, which was attended by 30 cultivators. Theoretically, the dialogue is highlighted regarding the long-term consequences of not treating with the correct dose, which leads to resistance to many types of diseases to commonly used therapeutic substances. Meanwhile, practical treatment instruction focuses on treating with prudence, which includes appropriate weight estimation, the use of sterile needles, and the essential role of veterinarian considerations in treatment decisions. This community service seeks to educate rabbit farmers on the long-term effects of resistance, which can result in significant long-term losses.
Dissemination of government policies regarding micro community activity restrictions to control the rate of Covid-19
Authors: Sa'ban L.M. Azhar , Achmad Farid Yusuf Nur , Basir Muh. Askal , Reni Andi , Sarah Siti , Syakur Abdan
Published: April 2022

This community service seeks to offer a thorough knowledge of the risks of Covid-19 dissemination, as well as raise public awareness about the need of following health standards and obeying Micro Community Activity Restrictions (PPKM) for the whole community. The issue is that the outcomes of related policies have not been able to considerably curb Covid-19's spread. The lecture technique is utilized to disseminate the community service material for all members of the Winning Village community. As a consequence of this socialization, the public's knowledge of Covid-19's spread and hazards, as well as public awareness of how to protect themselves while performing regular activities in workplaces, marketplaces, houses of worship, and other places, is increasing.
Local wisdom-friendly youth health services for students of Citra Bangsa Junior High School, Limo District, Depok
Authors: Ritanti Ritanti , Rosaine Mareta Dea , Nurdiantami Yuri
Published: April 2022

Adolescent health services for junior high school (SMP) students are very important in the effort to create a drug-free young generation, because they are the nation's next generation who will determine the nation's future fate. The primary objective of this program is to improve students' knowledge, attitudes, and behavior about drugs and adolescent health; develop the character of healthy, drug-free teenagers; and develop junior high school students' creativity in peer education as a promotional effort to create drug-free schools. Health education, training, mentoring, monitoring, and evaluation are some of the methods used. The assessment revealed a 98.2% increase in knowledge, a 94.7% increase in attitude, and a 93% increase in behavior. At Citra Bangsa Junior High School, the youth health service program "BERSINAR" (Bersih Narkoba) has also proven to be effective as a peer companion program. The outcome of this program suggest that schools and health centers play an active role in ongoing coaching, mentoring, monitoring, and evaluation activities.
Biomechanical Study on Three Screw-Based Atlantoaxial Fixation Techniques: A Finite Element Study
Authors: Erbulut Deniz Ufuk , Mumtaz Muzammil , Zafarparandeh Iman , Özer Ali Fahir
Published: April 2022

Study Design: This is a finite element study.Purpose: This study is aimed to compare the biomechanical behaviors of three screw-based atlantoaxial fixation techniques.Overview of Literature: Screw-based constructs that are widely used to stabilize the atlantoaxial joint come with their own challenges in surgery. Clinical and in vitro studies have compared the effectiveness of screw-based constructs in joint fixation. Nevertheless, there is limited information regarding the biomechanical behavior of these constructs, such as the stresses and strains they experience.Methods: A finite element model of the upper cervical spine was developed. A type II dens fracture was induced in the intact model to produce the injured model. The following three constructs were simulated on the intact and injured models: transarticular screw (C1– C2TA), lateral mass screw in C1 and pedicle screw in C2 (C1LM1–C2PD), and lateral mass screw in C1 and translaminar screw in C2 (C1LM1–C2TL).Results: In the intact model, flexion–extension range of motion (ROM) was reduced by up to 99% with C11–C2TA and 98% with C1LM1–C2PD and C1LM1–C2TL. The lateral bending ROM in the intact model was reduced by 100%, 95%, and 75% with C11–C2TA, C1LM1–C2PD, and C1LM1–C2TL, respectively. The axial rotation ROM in the intact model was reduced by 99%, 98%, and 99% with C11–C2TA, C1LM1–C2PD, and C1LM1–C2TL, respectively. The largest maximum von Mises stress was predicted for C1LM1–C2TL (332 MPa) followed by C1LM1–C2PD (307 MPa) and C11–C2TA (133 MPa). Maximum stress was predicted to be at the lateral mass screw head of the C1LM1–C2TL construct.Conclusions: Our model indicates that the biomechanical stability of the atlantoaxial joint in lateral bending with translaminar screws is not as reliable as that with transarticular and pedicle screws. Translaminar screws experience large stresses that may lead to failure of the construct before the required bony fusion occurs.
Nerve Conduction Studies in Post-COVID 19 Patients among Egyptian Patients
Authors: EL-Leithy Sally A. , Mohamed Hoda Atiatullah , El-Bably Mona Mohamed
Published: April 2022

Introduction: Corona viruses are large family of viruses that may cause disease in animals or humans. The most common symptoms are fever, cough, sneezing and shortness of breath. Extra-pulmonary manifestations include thromboembolism, renal, hepatic, gastrointestinal, endocrine, cardiac, dermatological and neurological manifestations. The neurological manifestations include headache, dizziness, encephalopathy, Guillen-barre, myalgia, stroke and insomnia. However, it has not been reported that patients with COVID-19 have any neurological manifestations. Aim: The aim of the study is to demonstrate the presence of neurological manifestations through nerve conduction studies among Egyptian post-COVID patients and its correlation with CRP levels. Methods: A comparative cross-sectional study of 90 post-COVIDmale patients, thirty patients were had mild symptoms during the disease activity, 30 had moderate symptoms and 30 had severe symptoms.In addition, 30 healthy control subjects that had no history of COVID-19 infection were included. Full History taking, Radiological, laboratory and neurological assessments were performed. Nerve conduction studies involve assessment of nerves of both upper and lower limbs. Results: There was a statistically significant difference as regards presence of symptoms and CRP levels in severe group in comparison to the other two groups. There was positive correlation between CRP levels and motor and sensory nerve latency, amplitude, and conduction velocity. No significant difference as regards F waves. Conclusion: COVID-19 may affect nervous system as well as respiratory system. This study offered new clinical information on COVID-19 which would help to raise awareness of involvement of nervous system. Patients who suffered from severe COVID infection have greater chance of neurological involvement. Also, there was positive correlation between CRP and both delayed latencies and conduction velocities in all nerves in severe post-COVID group.
Навчання іноземних мов: крос-культурний підхід
Authors: Бакум Зінаїда Павлівна , Пальчикова Олександра Олександрівна , Костюк Світлана Сергіївна
Published: April 2022

У монографії розроблено теоретичні та методичні засади упровадження крос-культурного підходу до навчання іноземних мов. Визначальна особливість пропонованої методики полягає у формуванні мовної особистості, яка прагне: зіставляти відмінні аспекти рідної та нерідної мов, культур задля запобігання різноманітних бар’єрів, що перешкоджають повноцінному розумінню й коректному відтворенню інформації в іншомовному культурному середовищі; послуговуватися культурно маркованими одиницями в межах певного контексту; коректно вживати вербальні й невербальні засоби передачі інформації; реалізовувати стиль поведінки відповідно до соціального статусу особи або певної ситуації тощо. Схарактеризовано сутність понять «мультикультуралізм», «полікультуралізм», «транскультура», «інтеркультура», «крос-культура»; «крос-культурний підхід до навчання іноземних мов», «крос- культурна компетентність особистості у процесі навчання іноземних мов»; визначено компоненти крос-культурної компетентності: лінгвістичний, соціокультурний, діяльнісний, ціннісно-емоційний; з’ясовано психологічні чинники, які сприяють успішному засвоєнню навчального матеріалу й удосконаленню умінь і навичок зіставляти лінгвістичні та культурні явища, що не збігаються в рідній та інших мовах. Теоретичну і прикладну цінність має лінгводидактичний інструментарій (об’єднання ефективних методів, прийомів, форм і засобів навчання). Монографія призначена для науковців, аспірантів, викладачів закладів вищої освіти, магістрантів, студентів-філологів, учителів-словесників, усіх, хто цікавиться проблемами навчання мови як іноземної.
Географія мінеральних ресурсів України
Authors: Паранько Ігор Степанович , Сивий Мирослав , Іванов Євген
Published: April 2022

Висвітлено теоретико-методологічні засади географії мінерально-сировинних ресурсів. Розглянуто умови формування мінеральних ресурсів України. Узагальнено багатий фактичний матеріал щодо основних груп корисних копалин держави. На цій основі проведено типізацію та аналіз загальнодержавної територіальної організації мінерально-сировинних ресурсів. Розглянуто основи раціонального використання мінеральних ресурсів та охорони надр в Україні. Для географів, геологів, екологів, краєзнавців, працівників гірничодобувної галузі і сфери державного управління.
Лексичний ексгiбiцiонiзм у романах Д. Мiтани «У пошуках втраченого автора» та Ю. Андруховича «Московiада»
Authors: Massayová Vanessa
Published: April 2022

Стаття присвячена компаративному розгляду творчостi Д. Мiтани та Ю. Андруховича на прикладi їхнiх романiв «У пошуках втраченого автора» й «Московiада» та за посередництвом такого поняття, як «лексичний ексгiбiцiонiзм». На основi цього зроблено висновок, за яким, незважаючи на значнi соцiокультурнi вiдмiнностi мiж двома авторами, вони досягають релевантних результатiв, спрямованих на подолання сексуальних табу та глибоке проникнення в основи людського iснування.
Antioxidant and anti-diabetic activities of crude ethanolic extract from the banana inflorescence of musa (ABB group) namwa maliong
Authors: Aiemcharoen Piyapat , Wichienchot Santad , Sermwittayawong Decha
Published: April 2022

Background: Banana inflorescence is one of the edible parts of banana. It is well-known to have antioxidants and anti-diabetic potential health benefits. Methods: In this study, the banana inflorescence from Musa (ABB group) Namwa Mali-Ong was prepared using ethanol extraction and investigated for its biochemical compositions and biological activities. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, ferric reducing antioxidant power (FRAP), and 2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radical scavenging activity assays were performed. The phytochemical composition of the extract was analyzed using the ultra-high-performance liquid chromatography-electrospray ionization quadrupole time-of-flight mass spectrometry (UHLC-ESI-QTOF/MS) technique. Additionally, the ability of the extract to stimulate glucose in C2C12 myotube was investigated. Results: The ethanolic extract of banana inflorescence contained carbohydrate, protein, phenolic, and flavonoid compounds. The results show that the extract exhibited low-level antioxidant activities.  For example, the half-maximal inhibitory concentration (IC50) in the DPPH and ABTS assays was at 27.89 ± 0.054 and 21.33 ± 0.87 mg/mL, respectively. Although the extract possesses low-level antioxidant activities, it stimulated glucose uptake in C2C12 myotubes in a dose- and time-dependent fashion. Consistently, the LC-ESI-QTOF/MS analysis in both positive and negative electrospray ionization modes reveals several components in the extract such as phytosphingosine and α-linolenic acid that have previously been shown to exhibit an anti-diabetic activity.Conclusion: The results show that the inflorescence ethanolic extract possesses antioxidant and anti-diabetic activities and may potentially be developed into a health-promoting product such as an anti-diabetic drug. Keywords: antioxidant activity; banana inflorescence; glucose uptake; anti-diabetic; C2C12 myotubes
An integrative ultrasound-pathology approach to improve preoperative phyllodes tumor classification: A pilot study
Authors: Locicero Paola , Weingertner Noëlle , Noblet Vincent , Mondino Marie , Mathelin Carole , Molière Sébastien
Published: April 2022

OBJECTIVE: Preoperative diagnosis of phyllodes tumor (PT) is challenging, core-needle biopsy (CNB) has a significant rate of understaging, resulting in suboptimal surgical planification. We hypothesized that the association of imaging data to CNB would improve preoperative diagnostic accuracy compared to biopsy alone. METHODS: In this retrospective pilot study, we included 59 phyllodes tumor with available preoperative imaging, CNB and surgical specimen pathology. RESULTS: Two ultrasound features: tumor heterogeneity and tumor shape were associated with tumor grade, independently of CNB results. Using a machine learning classifier, the association of ultrasound features with CNB results improved accuracy of preoperative tumor classification up to 84%. CONCLUSION: An integrative approach of preoperative diagnosis, associating ultrasound features and CNB, improves preoperative diagnosis and could thus optimize surgical planification.
Near real-time management of appliances, distributed generation and electric vehicles for demand response participation
Authors: Fernandes Filipe , Morais Hugo , Vale Zita
Published: April 2022

Consumer-centric energy management approaches are emerging as a major solution for future power systems. In this context, intelligent home management systems should control different kinds of devices existing in the houses assuring convenient comfort levels and understanding the users’ behaviour. At the same time, the home management systems should be able to interact with other actors such as energy communities, aggregators, and system operators. The main contribution of this work is a new methodology allowing intelligent management, in near real-time (1 minute), of different types of energy resources existing in a smart home. The energy resources include appliances and other loads, micro-generation, and electric vehicles. The proposed system includes a permanent evaluation of the operation state of each energy resource considering their functional model and the behaviour and comfort level defined by the users. Participation in demand response programs reducing the power consumption limits is also considered showing the advantage of the proposed approach. The case study contains two scenarios considering a demand response program of power limitation with 120 minutes duration. To guarantee the participation in these demand response events, the system should evaluate the priority of each device according to its model. A domestic consumer with 45 energy resources (appliances, generation, and electric vehicles) is used for demonstration purposes.
Effect of music on recovery after an anaerobic exercise
Authors: Atan Tülin
Published: April 2022

BACKGROUND:

For years, the effects of music on exercise performance have been researched. Recovery is extremely important for athletes, and therefore any factor that could affect it is of importance.

OBJECTIVE:

To assess the influence of listening to music on recovery after an anaerobic-exercise.

METHOD:

25 male athletes (age 21.76 [Formula: see text] 1.84 years) visited the laboratory on two occasions over a week. They performed the Wingate Anaerobic Test (WAnT) on two identical conditions but recovery was conducted ‘with’ and ‘without’ listening to music. Blood lactate concentration values were determined at 1, 5, 10 and 15 minutes during the recovery from the exercise. Heart rate (HR) values were determined every minute of the 15 minutes of recovery.

RESULTS:

There was no difference in the mean blood lactate concentration and HR during the recovery with and without music ([Formula: see text] 0.05). Results showed no significant differences between 2 recovery conditions in heart rate or blood lactate.

CONCLUSIONS:

Music cannot improve recovery after anaerobic performance and it cannot be used as a mean to enhance recovery after an anaerobic-performance.
Effects of a Thorstensson fatiguing protocol on isometric and isokinetic performance
Authors: Mackey Cameron S. , Thiele Ryan M. , Sanders David J. , DeFreitas Jason M.
Published: April 2022

OBJECTIVE:

Having participants perform 50 maximal isokinetic contractions, as introduced by Thorstensson and Karlsson (1976), is to this day one of the most commonly used fatigue protocols. Purpose: To determine to what extent a Thorstensson fatiguing protocol affects isokinetic and isometric performance characteristics.

METHODS:

Twenty-five college-aged men performed an isokinetic fatigue protocol consisting of 50 maximal elbow flexions at a moderate speed (180[Formula: see text] [Formula: see text]s[Formula: see text]). Pre- and post-tests were used to calculate fatigue indices (FI%) for the following variables: isometric and isokinetic peak torque (PT), isometric rate of torque development (RTD), and maximum acceleration (ACC[Formula: see text]).

RESULTS:

Each of the four dependent variables significantly decreased with fatigue (each demonstrated [Formula: see text] 0.001), but not of the same magnitude. Isometric PT FI ([Formula: see text]18.7%) was significantly less than isokinetic PT FI ([Formula: see text]45.1%, [Formula: see text] 0.001) and ACC[Formula: see text] FI ([Formula: see text]26.3%) was significantly less than isometric RTD FI ([Formula: see text]54.9%, [Formula: see text] 0.001). There was a significant positive relationship between isometric and isokinetic PT FI% ([Formula: see text] 0.60, [Formula: see text] 0.002) as well as between isometric PT FI% and RTD FI% ([Formula: see text] 0.40, [Formula: see text] 0.046). There was no significant relationship observed between RTD FI% and ACC[Formula: see text] FI% nor between isokinetic PT FI% and ACC[Formula: see text] FI%.

CONCLUSIONS:

This investigation observed different patterns of response in maximal strength between isometric and isokinetic assessments following a isokinetic fatigue protocol. Additionally, the ability to rapidly generate strength and velocity had significantly different responses to fatigue between isometric and dynamic assessments. Due to these different responses, we recommend that assessments of fatigue at least include the same testing modality as the modality of the fatigue protocol.
Making the Case for Accelerated Withdrawal of Aducanumab
Authors: Whitehouse Peter , Gandy Sam , Saini Vikas , George Daniel R. , Larson Eric B. , Alexander G. Caleb , Avorn Jerry , Brownlee Shannon , Camp Cameron , Chertkow Howard , Fugh-Berman Adriane , Howard Rob , Kesselheim Aaron , Langa Kenneth M. , Perry George , Richard Edo , Schneider Lon
Published: April 2022

The controversial approval in June 2021 by the Food and Drug Administration (FDA) of aducanumab (marketed as Aduhelm), Biogen’s monoclonal antibody for patients with Alzheimer’s disease, raises significant concerns for the dementia field and drug approval process, considering its lack of adequate evidence for clinical efficacy, safety issues, and cost. On 15 December 2021, an international group of clinicians, basic science experts, psychological and social science researchers, lay people with lived experience of dementia, and advocates for public health met to discuss making a recommendation for whether aducanumab’s approval should be withdrawn. Attendees considered arguments both in favor of and in opposition to withdrawal and voted unanimously to recommend that the FDA withdraw its approval for aducanumab and to support the Right Care Alliance’s filing of a formal Citizen Petition to this effect.
Including People with Parkinson’s Disease in Clinical Study Design and Execution: A Call to Action
Authors: Meinders Marjan J. , Donnelly Anne C. , Sheehan Margaret , Bloem Bastiaan R.
Published: April 2022

The proactive inclusion of patients in the design and execution of clinical studies has been an emerging focus for decades. Such participatory research helps to design studies better, by addressing relevant research questions and defining outcomes that matter to patients. Yet, much remains to be learned about the best methods and exact impacts of patient engagement in research in general, and more specifically, about the specific challenges that come with Parkinson’s disease. Here we present the lived experiences of patient researchers living with Parkinson’s disease, as a motivation for the value of their perspectives in research and as a call to action for empirical research on how to successfully include patient researchers.
Spark plug defects detection based on improved Faster-RCNN algorithm
Authors: Liu Yuhang , Liu Yi , Zhang Pengcheng , Zhang Quan , Wang Lei , Yan Rongbiao , Li Wenqiang , Gui Zhiguo
Published: April 2022

The objective of this study is to apply an improved Faster-RCNN model in order to solve the problems of low detection accuracy and slow detection speed in spark plug defect detection. In detail, an attention module based symmetrical convolutional network (ASCN) is designed as the backbone to extract multi-scale features. Then, a multi-scale region generation network (MRPN), in which InceptionV2 is used to achieve sliding windows of different scales instead of a single sliding window, is proposed and tested. Additionally, a dataset of X-ray spark plug images is established, which contains 1,402 images. These images are divided into two subsets with a ratio of 4:1 for training and testing the improved Faster-RCNN model, respectively. The proposed model is transferred and learned on the pre-training model of MS COCO dataset. In the test experiments, the proposed method achieves an average accuracy of 89% and a recall of 97%. Compared with other Faster-RCNN models, YOLOv3, SSD and RetinaNet, our proposed new method improves the average accuracy by more than 6% and the recall by more than 2%. Furthermore, the new method can detect at 20fps when the input image size is 1024×1024×3 and can also be used for real-time automatic detection of spark plug defects.