bluuebunny/crossref_metadata_2025 huggingface dataset:
First-Principles Investigation of Ti2CSO and Ti2CSSe Janus MXene Structures for Li and Mg Electrodes
Authors: Siriwardane Edirisuriya , Hu Jianjun
Published: April 2021

While lithium battery electrodes are constantly being improved in terms of their properties, discovering new materials with alternative energy carriers like Mg are important to lower the cost of production and to enhance the energy density. MXenes are a type of highly investigated materials with promising energy applications due to their excellent electronic conductivity and good mechanical and dynamical stability. Experimentally realized Janus MoSSe nanosheets provided promising results for battery electrodes. It is known that the surface terminations of MXenes highly affect on the electrochemical properties and the diffusion barriers of ions. Inspired by this, we studied Ti2CSO and Ti2CSSe Janus MXenes for Li and Mg electrodes. Our density functional theory-based, first-principles calculations indicate that both monolayers are thermodynamically, mechanically, and dynamically stable. We calculated that the average voltages for Li and Mg adsorbed Ti2CST (T = O, Se) MXenes are approximately 0.95 and 0.2 V, respectively. The maximum voltage for Ti2CSTLix is about 2 V, and that for Ti2CSTMgx is around 0.45 V. The Mg adsorbed Ti2CSO monolayer exhibits the highest gravimetric capacity (524.54 mAh/g) compared to that of other Janus MXenes considered in this paper. For Ti2CSSeLix, we obtained a higher capacity (230.45 mAh/g) and a lower diffusion barrier (0.191 eV) than that of most of the Li adsorbed S-functionalized MXenes.
Biosynthetic Crossover of 5-Lipoxygenase and Cyclooxygenase-2 Yields 5-Hydroxy-PGE2 and 5-Hydroxy-PGD2
Authors: Nakashima Fumie , Suzuki Takashi , Gordon Odaine N. , Golding Dominic , Okuno Toshiaki , Gimenez-Bastida Juan Antonio , Yokomizo Takehiko , Schneider Claus
Published: April 2021

Biosynthetic crossover of 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) enzymatic activities is a productive pathway to convert arachidonic acid into unique eicosanoids. Here we show that COX-2 catalysis with 5-LOX derived 5-hydroxy-eicosatetraenoic acid yields the endoperoxide 5-hydroxy-PGH2 that spontaneously rearranges to 5-OH-PGE2 and 5-OH-PGD2, the 5-hydroxy analogs of arachidonic acid derived PGE2 and PGD2. The endoperoxide was identified via its predicted degradation product, 5,12-dihydroxy-heptadecatri-6E,8E,10E-enoic acid, and by SnCl2-mediated reduction to 5-OH-PGF2a. Both 5-OH-PGE2 and 5-OH-PGD2 were unstable and degraded rapidly upon treatment with weak base. The instability hampered detection in biologic samples which was overcome by in situ reduction using NaBH4 to yield the corresponding stable 5-OH-PGF2 diastereomers and enabled detection of 5-OH-PGF2a in activated primary human leukocytes. 5-OH-PGE2 and 5-OH-PGD2 were unable to activate EP and DP prostanoid receptors suggesting their bioactivity is distinct from PGE2 and PGD2.
Simultaneous Optimization of Donor/acceptor Pairs and Device Specifications for Non-Fullerene Organic Solar Cells Using a QSPR Model with Morphological Descriptors
Authors: Wen Yaping , Yan Bohan , Gaudin Theophile , Ma Jing , Ma Haibo
Published: April 2021

In addition to designing new donor (D) and/or acceptor (A) molecules, the optimization of experimental fabrication conditions for the organic solar cells (OSCs) is also a complex, multidimensional challenge, which hasn’t been theoretically explored. Herein, a new framework for simultaneous optimizing D/A molecule pairs and device specifications of OSCs is proposed, through a quantitative structure-property relationships (QSPR) model built by machine learning. Combining the device parameters with structural and electronic variables, the built QSPR model achieved unprecedentedly high accuracy and consistency. Additionally, a huge chemical space containing 1,942,785 D/A pairs is explored to find potential synergistic ones. Favorable expereimental parameters such as root-mean-square (RMS) and the D/A ratio (DAratio) are further screened by grid search methods. Overall, this study suggests the feasibility to optimize D/A molecule pairs and device specifications simultaneously by enabling better-informed and data-driven techniques and this could facilitate the acceleration of improving OSCs efficiencies.
Botany, Traditional Uses and Pharmacology of Bukkun Booti - Phyla nodiflora (L.) Greene: An Underexposed Botanical Drug of AYUSH-Unani System
Authors: Mohd Kashif Husain  , Goli Penchala Pratap  , Mokhtar Alam  , Ghazala Javed  , Munawwar Husain Kazmi
Published: April 2021

Bukkun Booti (Phyla nodiflora (L.) Greene; Syn. Lippia nodiflora (L.) Michx.), of Verbenaceae, is a fast-growing creeping perennial medicinal herb, has a very long history for human use as it is generally distributed throughout the world. The plant has been traditionally used and recorded in AYUSH-Ayurveda, Unani and Siddha systems of medicine. In the Unani System of Medicine (USM), the Bukkun Booti is used for detoxification of the blood. It is useful in Bawāsīr (bleeding piles), Ru‘af (epistaxis), Hasāh al-Mathāna (cystolithiasis), Sozāk (gonorrhea) ‘Usr al-Bawl (dysuria) and Hummayat (fevers). Ethno-medicinally, it has been widely used as a traditional folk medicine to treat and cure ailments by the local tribal and other communities. The entire plant is diuretic, febrifuge, stomachic and astringent; good for ulcers, wounds, asthma, bronchitis, knee-joints and to ladies after delivery. Bukkun Booti is a rich source of antioxidants and secondary metabolites, and aerial parts are reported to contain phenolic compounds (flavonoids), which are found to have a broad array of reported pharmacological actions such as; antibacterial, anti-inflammatory, antioxidant, antidiabetic and hepatoprotective properties. The purpose of this review paper is to bring together the available information on the current status and therapeutic uses of Bukkun Booti in the Unani System of Medicine and to discuss the botany and importance of the plant on the basis of folk uses, pharmacological activities and chemical constituents. The potential characteristics of P. nodiflora could be utilized more efficiently by linking the bridge of traditional uses, pharmacology and phytochemistry through an integrated approach.
Phytochemical Screening and Antibacterial Activity of an Epiphytic Orchid Rhynchostylis retusa (L.) Blume. Collected from Kannur District, Kerala, India
Authors: Ruthisha PK
Published: April 2021

Treatment with medicinal plants consists of the ancient tradition of India and which has been continued for years. Our ancestors collected rare plants from forests and mountains for treatment purpose. At the same time, they give deep concern for the conservation of the species on the earth. Their knowledge and services are not profitable but valuable. The study is focused on the phytochemical and antimicrobial activity of the medicinal plant Rhynchostylis retusa of the family Orchidaceae. The plant is growing in sacred groves and local gardens of Payyanur of Kannur district, Kerala, India and used for traditional healing practices. The Orchidaceae family includes many plants having medicinal properties, but most of them were not studied or exploited yet. Qualitative analysis of primary metabolites and secondary metabolites indicates the presence of phytochemicals in Rhynchostylis retusa. The total alkaloid, carbohydrate, protein, phenolic compounds and flavonoids were seen in significant amount in this plant. In vitro antibacterial (agar well diffusion) activity was done by gram-negative Pseudomonas aeruginosa (ATCC 27853), gram-positive Streptococcus mutans (MTCC 890), Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922) and antifungal activity by Aspergillus niger (ATCC 16404). The plant extracts exhibited potent antimicrobial activity against these strains. The studies with the medicinal plant R.retusa make clear that the plant is rich in active components and phytochemicals. The plant contains a favourable amount of phytochemicals and this makes them cure various diseases. The plant also shows antioxidant and antibacterial activities.
Regulatory Approval process for marketing drug in Japan
Authors: Uma Maheshwari A  , Kamaraj R
Published: April 2021

For the development of new drug, it requires a greater amount of research work in chemistry, Manufacturing, control, Preclinical and clinical trials. The drug approval process in all regulatory market carrying responsibilities on multiple factors such as data, safety, efficacy to public health in a country. Current constrain of affairs reveals diverse countries need to follow different regulatory requirements for Regulatory approval process for marketing drug in the different regulatory market of the country to ensure safety and efficacy of the product. In order to conduct a regulatory process for approval of a drug, every country has their unique regulation, guidelines, legislation and respective regulatory authority. Japan has its own regulatory authority for drug and medical device called the Ministry of Health, Labour, and Welfare (MHLW), Pharmaceuticals and Medical Devices Agency (PMDA), respectively. In the Japan Ministry of Health, Labour, and Welfare are overseeing the approval procedure of New drug, Generic Drug and Orphan Drug also. In that regard, the Drug Approval process followed in Japan ensures that every company has adhered to specific guideline available in their respective website. The drug comes to market with safety, efficacy to enhance the health of people in Japan by scrutinised process. It results into the longevity of human, which is so apparent in their demographic chart of Japan's Population.
Association of flat foot with obesity in middle-aged individuals
Authors: Manish Kumar  , Divya Sanghi  , Jyoti Kataria  , Pratiksha Arya
Published: April 2021

Flat foot can be classified as a foot with collapsed or minimally developed longitudinal arches. Another term used for flat foot is pes planus in which the medial longitudinal arch of the foot has collapsed. The frequency of flat foot is not explained properly as there is a lack of comprehensive definition, better method to classify and proper radiographic criteria for defining a flat foot. Due to obesity, there is an increase in forces at weight-bearing areas of the lower limb and feet. Long term continuous loading effect, specifically related to the feet region due to obesity, has not been extensively evaluated. To find the association of flat foot with obesity in middle-aged Individuals. A total of 120 subjects in the age range of 30 to 50 years were recruited with 60 subjects in each two groups formed on the basis of BMI indexes as Group A (Normal with BMI score 17.5 – 22.99) and Group B (Obese with BMI score >28). Navicular Drop Test and Waist/Hip ratio were measured using Brody’s method and inch tape method, respectively and the correlation between Navicular drop and W/H ratio was evaluated thereafter in both the groups. The result of the study demonstrated that there is a statistically significant positive correlation between navicular drop test and W/H ratio in both the groups, with a stronger association in the obese group (r=0.7 at p=0.05). This study concluded that there is a strong correlation between flat foot and body weight in middle-aged individuals. Hence individuals should be physically active to maintain their body weight in order to avoid any biomechanical alteration in feet structures.
Differences of Confirmatory Case, Mortality Rate and Incident Mortality of COVID-19 in Indonesia, Asia and Who Online Data Case Study
Authors: Susanto Nugroho
Published: April 2021

Turkish Ministry of Health estimated that 6.3% cases of COVID-19 fatality in April 2020 and 2.1% cases of COVID-19 mortality are associated with multi-factors. COVID-19 is very dangerous for moderate respiratory infection and has higher mortality compared to other diseases such as SARS-CoV-2. The study aims to compare case confirmation, mortality and compare incidence rate mortality between Indonesia and the world’s general situation. The study designs used a cross-sectional study with secondary data. The study population was people who have been diagnosed to covid-19 based on the website with URL: https://covid19.who.int/ and URL: https://covid19.kemkes.go.id/ for the period of March 2020 to November 2020. The Independent Variables are areas of disease i.e. Indonesia, Asia, and world area. Statistical analysis was performed using SPSS. Data were analyzed with ANOVA. Average of confirmatory covid-19 is 1891.65±1468.412 in Indonesia, 41146.94±34159.12 in Asia, and 211914.42±128689.95 according to WHO. The average mortality was 62.29±37.69 in Indonesia, 635.36±453.68 in Asia, and 5279.71±1540.41 according to WHO. The incidence mortality rate was 0.046±0.0326 in Indonesia, averaged 0.023±0.0157 in Asia, and averaged 0.035±0.0231 according to WHO. There was a significant difference in confirmatory case between Indonesia, Asia and WHO with p<0.001, a significant difference in mortality between Indonesia, Asia and WHO with p<0.001, and significant difference in incidence mortality between Indonesia, Asia, and Indonesia with p<0.001. The study was concluded that there are significant differences in confirmatory case, death, and incident mortality between Indonesia, Asia and WHO. Confirmatory case and mortality were higher in WHO and Asia when compared to Indonesia, but incidence mortality was high in Indonesia when compared to WHO and Asia.
Silver i-motifs and their antibacterial activity
Authors: Bratt Jessica
Published: April 2021

The spread of antibiotic resistance and the emergence of multi-drug resistant bacteria is a major threat to public health. This study investigated a unique cytosine rich DNA structure, the i-Motif to deliver soluble Ag+ as a novel antimicrobial agent (AgiMs). AgiMs were evaluated in vitro against P. aeruginosa and A. baumannii strains. AgiMs displayed significant antibacterial activity against both P. aeruginosa and A. baumannii (median MIC: 0.875 µM and 0.75 µM, respectively) by rapid, bactericidal and concentration-dependent effect. Low concentrations of AgiMs showed efficacy against PAO1 20-h biofilms, resulting in 57% reduction in biomass (5 x MIC). A single dose of AgiMs extended survival of G. Mellonella larvae, with the therapeutic benefit paralleled in the reduction of internal bacterial load. Synergistic interactions were observed with the combination of AgiMs and tobramycin, a common antibiotic used to treat P. aeruginosa infections; indicating the potential for AgiMs to reinstate the potency of current antibiotics. This silver-based agent might be an alternative to the failing antibiotic regimes for MDR resistant infections. Further in vitro and in vivo studies are warranted to confirm the therapeutic potential.
PEMBERDAYAAN KELOMPOK NELAYAN MELALUI MEDIA KOMUNIKASI LUAR RUANGAN DI DESA GRUJUGAN KECAMATAN GAPURA
Authors: Yuliastina Roos , Inayati Hosnu
Published: April 2021

Pemberdayaan Kelompok Nelayan Melalui Media Komunikasi di Desa Grujugan Kecamatan ini adalah tindak lanjut dari kegiatan penelitian yang dilakukan pada kelompok nelayan di lokasi yang sama dari persepektif komunikasi kesehatan. Kegiatan pengabdian ini lebih menekankan pada bentuk pendampingan melalui kegiatan sosialisasi penerapan  perilaku hidup sehat dan bersih (PHBS) dalam kegiatan sehari-hari. Tujuan dari kegiatan pengabdian ini berupaya untuk mengedukasi dan memberdayakan masyarakat pesisir, khususnya kelompok nelayan di dusun Palegin dan dusun Karang Mimbah desa Grujugan Kecamatan Gapura dari aspek komunikasi kesehatan. Metode kegiatan yang dilakukan (1) kegiatan sosialisasi tentang manfaat dan dampak jika menerapkan berprilaku hidup sehat dan bersih (PHBS). Seperti membasuh tangan sebelum makan, tidak membuang sampah sembarangan, dan tidak buang air besar (BAB) sembarangan. (2) melakukan kampanye penerapan PHBS melalui media komunikasi luar ruangan, melalui pemasangan Banner dan poster. Media kampanye PHBS dipasang pada lokasi – lokasi  strategis seperti di kantor balai desa dan rumah warga yang dan pertokoan di desa setempat. Adapun isi kampanye media luar ruangan tersebut, adalah tatacara perilaku hidup bersih dan sehat serta penerapan protokoler kesehatan sesuai standar covid - 19. Luaran kegiatan PkM ini diantaranya; 1) Publikasi pada jurnal pengabdian e-ISSN, 2) Publikasi melalui media online, 3) Hak Cipta – karya seni berupa poster kegiatan PkM.
On Fair Performance Comparison between Random Survival Forest and Cox Regression: An Example of Colorectal Cancer Study
Authors: Cetin Sirin , Ulgen Ayse , Dede Isa , Li Wentian
Published: April 2021

Random Forest (RF), a mostly model-free and robust machine learning method, has been successfully applied to right-censored survival data, under the name of Random Survival Forest (RSF). However, RF/RSF has its distinct strategies in classification and prediction. First, it is an ensemble classifier and its performance is an average of multiple rounds of data fitting. Second, the training set is a bootstrap (sampling with replacement) generated set with repeated used of roughly 2/3 of all samples and testing set consists of those not used (out of bag samples). Both features are not intrinsic to Cox regression or other single classifiers. Not considering these two features could potentially lead to a partial comparison between the performance of the two methods. By using a colorectal survival dataset, we illustrate the problems of using k-fold cross-validation, using only one resampling without an ensemble average, and using the whole dataset for both fitting and testing, in Cox regression, when comparing with RSF. We provide a more accessible R code for simple calculation of discordance index (D-index) and unweighted integrated Brier score (IBS) for Cox regression, and unweighted IBS for RSF. Doi: 10.28991/SciMedJ-2021-0301-9 Full Text: PDF
Non-mass Enhancement in Breast MRI: Characterization with BI-RADS Descriptors and ADC Values
Authors: Buchberger Wolfgang , Oberaigner Willi , Kremser Christian , Gautsch Kurt , Siebert Uwe
Published: April 2021

Objectives: The purpose of this study was to assess the accuracy of contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging in distinguishing benign from malignant non-mass-like breast lesions. Methods: 103 lesions showing non-mass-like enhancement in 100 consecutive patients were analyzed. Distribution, internal enhancement patterns, and contrast kinetic curve patterns were classified according to the BI-RADS lexicon. Apparent diffusion coefficient (ADC) values were obtained from manually placed regions of interest (ROIs) on diffusion-weighted images. The optimal ADC value threshold for the distinction between benign and malignant lesions was determined by ROC analysis. Univariate and multivariate analyses were performed to identify independent predictors of malignancy, and the probability of malignancy was calculated for various combinations of findings. Histological diagnosis obtained by means of core needle biopsy was used as gold standard. Results: According to the univariate and multivariate analysis, odds ratios for malignancy were significantly elevated for clumped or clustered ring internal enhancement and low ADC values (p < 0.001), whereas distribution patterns and contrast kinetic patterns were not significantly correlated with benignity or malignancy. In non-mass lesions with homogeneous or heterogeneous internal enhancement and ADC values greater than 1.26×10-3mm2/s, no malignancy was detected, while all other combinations of findings had a probability of malignancy ranging from 22.2 to 76.6%. Conclusions: A combination of BI-RADS descriptors of internal enhancement and ADC values is useful for the differential diagnosis of lesions showing non-mass enhancement. Lesions with homogeneous or heterogeneous enhancement and high ADC can be followed up, while all other lesions should be biopsied. Doi: 10.28991/SciMedJ-2021-0302-1 Full Text: PDF
Why did the COVID-19 Epidemic Stop in China and does not Stop in the Rest of the World? (Application of the Two-Component Model)
Authors: Dimaschko Juri , Shlyakhover Vladimir , Iabluchanskyi Mykola
Published: April 2021

The vastly different courses of the COVID-19 epidemic in China and the rest of the world are investigated and explained within two-component epidemic model. The model is based on separate accounting for the contribution to the epidemic from two types of immune response to a viral infection - innate and adaptive immunity. Any infected person becomes asymptomatic with probability (1−𝑝) or symptomatic with probability 𝑝. In the first case, innate immunity is sufficient to protect a person. In the second case, innate immunity is insufficient, and adaptive immunity comes into play. In the asymptomatic state, the person remains outwardly healthy, mobile and can spread the infection. In the symptomatic state, the person becomes ill, isolated and cannot spread the infection. We assume that the contribution to the epidemic process from asymptomatic carriers is dominant in comparison with the contribution from the usual incubation period in the symptomatic state. The key parameters of the model are the virus lifetime 𝑇 in the asymptomatic state and the spread rate 𝛽. At moderate 𝛽𝑇 values, the model describes a long, slowly decreasing morbidity plateau, which transforms into wave-like solution at 𝛽𝑇. In the case of 𝛽𝑇→∞, which corresponds to a stable non-pathogenic strain, the model solution is limited to single wave only. We believe that the spread of such a non-pathogenic strain and its subsequent dominance is responsible for ending the epidemic after the single wave of incidence in China. A way to stop the epidemic in the rest of the world may consist in displacing the circulating pathogenic virus with its stable non-pathogenic strain. Doi: 10.28991/SciMedJ-2021-0302-2 Full Text: PDF
Knowledge, Attitude, and Practices towards COVID-19 during the Rapid Rise Period: A Cross-Sectional Survey among Public University Students of Bangladesh
Authors: Rahman Md Mostafizur , Jhinuk Jannate Mehjabin , Nabila Nadia Habib , Yeasmin Mir Taj Mira , Shobuj Ifta Alam , Sayma Tammim Hossain , Faruk Fariha , Shah Shakhawat Hossain
Published: April 2021

Bangladesh has experienced long term COVID-19 impact in the education sector where university students have suffered a lot. This cross-sectional study intended to evaluate the health behavior of public university students towards the COVID-19. The convenience sampling technique was employed during the rapid COVID-19 period. A total of 952 public university students participated in the KAP survey. Statistical analyses were performed depending on the data type. Study population demonstrated exemplary COVID-19 knowledge along with positive attitudes and preventive practices towards the COVID-19. Gender, university year, and major were determined as associating factors with their overall KAP. Female students reported better knowledge and practice regarding COVID-19 than their counterpart male students. Students living in the capital Dhaka city did not show positive attitudes towards COVID-19 compared to the students living outside the city. Students who were without their families demonstrated better attitudes compared to the students with their families. Broadcast media, print media, the internet, university, and social media were identified as sources of COVID-19 precautionary measures information for these students. Students showed better knowledge and attitude levels when used print media and university respectively compared to the students who used surrounding people as a source of information. This study enhances our understanding of the health behavior of public university students of Bangladesh. It has also determined the associating factors with their KAP level. The outcome of this study can assist the government, organizations, and the university to prepare for a comprehensive pandemic control effort. Doi: 10.28991/SciMedJ-2021-0302-4 Full Text: PDF
Exon Array Analysis to Identify Diethyl-nitrosamine Differentially Regulated and Alternately Spliced Genes in Early Liver Carcinogenesis in the Transgenic Mouse ATT-myc Model
Authors: Elalfy Mahmoud M. , Borlak Jürgen
Published: April 2021

Objectives: To identify the regulated genes or the spliced genes of diethylnitorsamine (NDEA) in ATT-myc mice versus control group. Methods: We analysed the 9 hybridizations on the MouseExon10ST array of NDEA treatments and control non- transgenic by application of a mixed model analysis of variance. Results: The 907 genes had regulated significantly between the groups and 916 genes had regulated with a significant exon-group interaction among of them 150 genes had regulated with both gene and possible splicing differences (p<0.01). The 7,618 genes had tested for the alternative gene up-regulation and splicing and compared to the gene-classifications. The genes functions, pathways and gene-classifications in the current study had presented in the contingency table analysis of the set of the regulated genes and alternatively spliced that regulated significantly in the ATT-myc mice treated by diethylnitorsamine versus control non-transgenic. The GOMolFn of gene-classification had 321 groups that had significantly regulated in the set of the regulated genes or differentially spliced. While the GOProcess of gene-classification had 330 groups that had significantly regulated in the set of differentially regulated genes or spliced. Additionally, the CELlLoc of gene-classification had 70 groups that had significantly regulated in the set of differentially regulated genes spliced. Finally, the Pathway gene-classification had 8 groups that had significantly regulated in the set of differentially regulated genes or spliced (p<0.01) in diethylnitorsamine when compared to control group. Conclusion: we summarized the toxicogenomics induced by diethylnitrosamine in early liver carcinogenesis in ATT-myc transgenic mice of liver cancer. Doi: 10.28991/SciMedJ-2021-0302-6 Full Text: PDF
Condylomata Acuminata in Childhood
Authors: São Pedro Maria , C. Pessoa Tânia , Mourato Paula , Correia Susana
Published: April 2021

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Методичні основи побудови програми фізичної терапії для осіб після остеосинтезу вертлюгової западини
Authors: Pasenko Maryna , Hlyniana Oksana
Published: April 2021

Актуальність. Переломи вертлюгової западини відносно до всіх переломів таза, за даними різних учених становлять від 6 до 23 %. За останній час статистика травм і пошкоджень опорно-рухового апарату вказує на те, що частота переломів вертлюгової западини нині не має тенденції до зниження. За підрахунками ВОЗ, значна кількість хворих після переломів вертлюгової западини залишаються інвалідами й мають ускладнення у вигляді постравматичного артрозу та асептичного некрозу кульшового суглоба. Профілактика цих наслідків є досить складним завданням. Якщо лікуванню переломів кульшової западини, консервативному та оперативному, в гострому періоді травми приділяється увага багатьма авторами, то фізичної терапії стосуються лише поодинокі роботи, пов’язані із застосуванням окремих лікувальних факторів. У статті розглянуто традиційні та сучасні підходи до побудови процесу фізичної терапії хворих після оперативного лікування перелому вертлюгової западини. Розглянуті положення міжнародної класифікації функціонування стосовно організації й направле- ності заходів фізичної терапії. Наведено принципи фізичної терапії та підходи до постановки SMART-цілей. Мета дослідження – визначити методичні основи та особливості побудови програми фізичної терапії хворих після остеосинтезу вертлюгової западини. Матеріал і методи дослідження – аналіз науково-методичної літератури, синтез й узагальнення. Результати роботи. Проведено аналіз науково-методичної літератури та визначення стану програм фізичної терапії хворих після остеосинтезу вертлюжної западини ми виявили їх незначну кількість у вітчизняних і зарубіжних джерелах, а також відсутність сучасних підходів у їх побудові. Тож нами розглянуто послідовність створення програми фізичної терапії, починаючи від принципів, МКФ, SMART-цілей, а також дій, які виконує мультидисциплінарна команда. Висновки. Побудовано блок-схему процесу фізичної терапії з комплексним використанням засобів і методів після остеосинтезу переломів вертлю- гової западини, визначення цілей та встановленням напряму реабілітаційного процесу, що відбувається з дотриманням принципів фізичної терапії, з урахуванням МКФ та постановкою SMART-цілей.
Lezzet Algısının Oluşmasında Çevresel ve Genetik Faktörlerin Etkileri
Authors: MUSLU Mücahit , GÖKÇAY Gülden Fatma
Published: April 2021

Lezzet algısı kimyasal, hormonal ve sinirsel uyarılarla oluşan, birçok organ ve hormonun etkili olduğu karmaşık bir sistemdir. Lezzet algısı genel olarak hissedilen tat, koku, doku ve görsel uyarıların bir bütünü olarak değerlendirilmektedir. Yaş, cinsiyet, hastalıklar, psikolojik durum, gebelik, obezite varlığı, sigara kullanımı, sosyokültürel etmenler, beslenme ve besin ögeleri gibi birçok çevresel ve genetik faktöre göre değişiklik göstermektedir. Bu algı besin tercihleri ve besin tüketimini etkileyen önemli bir faktördür. Acı, tatlı, ekşi, tuzlu ve umami tatları dışında yağ, nişasta ve metalik tatlar lezzet algısını etkilemektedir. Lezzet algısı, tat algılamada görevli reseptörleri üreten genlerde bulunan genetik polimorfizmlerle kısmen açıklanabilmekte ve bireyler arasında büyük farklılıklar göstermektedir. Bu tatların algılanmasında TAS1R, TAS2R, CA6, TRPV, SCNN, PKD1 gibi gen aileleri ve reseptörler etkili olmaktadır. Bu nedenle lezzet algısının genetik ve çevresel faktörlerinin daha iyi anlaşılması için kaliteli çalışmaların artması gerekirken, bu konu besin tercihlerinin anlaşılması ve çağımızın sorunu beslenme kökenli hastalıklarla mücadele konusunda büyük önem taşımaktadır.
INTELIGENCIA EMOCIONAL EN EL DESEMPEÑO DOCENTE.
Authors: Pincay-Aguilar Iván , Candelario-Suarez Gabriela , Castro-Guevara Jesús
Published: April 2021

En esta investigación se estudió la relación existente entre la inteligencia emocional (IE) y la evaluación de desempeño (ED) que se realiza la institución como parte de los procesos, comportamientos y competencia de la academia a nivel universitario, a partir de una muestra de 150 docentes, en edades comprendidas entre los 25 y 69 años, en el contexto de Milagro- Guayas, Ecuador. El objetivo del estudio fue establecer las características de inteligencia emocional presente en los docentes en correlación al nivel de desempeño laboral.  Para la recolección de la información de la primera variable, se utilizó el test Traid Meta-Mood Scale (TMMS-24), instrumento utilizado para medir el índice (IE) presente en los docentes, contiene 24 ítem divididos en tres categorías atención, claridad y reparación. Para medir el desempeño docente se consideró los datos proporcionados por el departamento de evaluación y aseguramiento de la calidad de la institución. Esta evaluación consideró cuatro parámetros; la auto evaluación, evaluación de pares, heteroevaluación y evaluación directivos. Los datos fueron analizados de forma descriptiva y correlacional. Como conclusión relevante, se estableció que, mientras mayor son los niveles de inteligencia emocional, mayor es el desempeño laboral en los docentes investigados.

 

Abstract

In this research we studied the relationship between emotional intelligence (EI) and performance evaluation (ED) carried out by the institution as part of the processes, behaviors and competence of the academy at the university level, starting from a sample of 150 teachers, between the ages of 25 and 69, in the context of Milagro-Guayas, Ecuador. The objective of the study was to establish the characteristics of emotional intelligence present in teachers correlated to the level of work performance. For the collection of the information of the first variable, the Traid Meta-Mood Scale (TMMS-24) was used, an instrument used to measure the index (IE) present in teachers, it contains 24 items divided into three categories. Attention, clarity and repair. To measure the teaching performance, the data provided by the department of evaluation and assurance of the quality of the institution was considered. This evaluation considered four parameters; self-evaluation, peer evaluation, hetero-evaluation and management evaluation. The data was analyzed in a descriptive and correlational manner. As a relevant conclusion, it was established that, the higher the levels of emotional intelligence, the greater the job performance of the investigated teachers.
EL PSICÓLOGO COMO DOCENTE EN EL SIGLO XXI.
Authors: Arias Rivera Shirley
Published: April 2021

Este ensayo científico tiene como objetivo la profundización, análisis y síntesis de los cambios necesarios para el ejercicio de la docencia por parte del profesional psicólogo del siglo XXI. Este análisis utiliza fuentes bibliográficas actualizadas además de la experiencia docente. Comienza caracterizando los actuales escenarios de la educación superior y particularmente se destaca los nuevos retos para el psicólogo formador de nuevos profesionales. En base a esto se describen algunas propuestas emergentes de la sociedad del siglo XXI, resaltando aquellos que tendrían mayor incidencia en el campo educativo general y de la enseñanza de la psicología en particular. Lo biocéntrico como eje de construcción de conocimiento, que desarrolla, influye y dinamiza este proceso. Lo sistémico-ecológico como parte de la metodología en el aula, en donde los estudiantes se convierten en sistemas abiertos que producen, intercambian y generan nuevas realidades, un proceso meta cognitivo que creará nuevos niveles de aprendizaje, así como la conformación de competencias sociales. La integración de la información en escenarios innovadores. Los enfoques de enseñanza que llevarán al docente a plantearse una postura ejecutiva, terapéutica o liberadora. Finalmente, se concluye señalando algunos de los principales retos en la formación profesional del futuro psicólogo.

Abstract

This scientific essay aims to deepen, analyze and synthesize the changes necessary for the exercise of teaching by the professional psychologist of the 21st century. This analysis uses updated bibliographic sources in addition to the teaching experience. Begins to characterize the current scenarios of higher education and particularly highlights the new challenges for the psychologist training new professionals. Based on this, some emerging proposals of 21st century society are described, highlighting those that would have greater incidence in the general educational field and the teaching of psychology in particular. The biocentric as the building block of knowledge, which develops, influences and dynamizes this process. The systemic-ecological as part of the methodology in the classroom, where students become open systems that produce, exchange and generate new realities, a meta-cognitive process that will create new levels of learning, as well as the conformation of social competences. The integration of information in innovative scenarios. The teaching approaches that will lead the teacher to consider an executive, therapeutic or liberating position. Finally, it is concluded by pointing out some of the main challenges in the professional training of the future psychologist.
HOGARES DISFUNCIONALES Y SU INCIDENCIA EN EL DESARROLLO SOCIO-AFECTIVO DE LOS.
Authors: Valverde Peralta Gustavo
Published: April 2021

El presente trabajo de investigación propone la incidencia de los hogares disfuncionales en el desarrollo socio-afectivo de los escolares, se entiende que dentro de las familias la presencia de conflictos puede llegar a ser parte de un proceso, sin embargo estas exacerbaciones de los mismos al intensificarse desborda en una serie de situaciones negativas que recaen sobre los  niños del hogar, el objetivo de este estudio es identificar la incidencia de los hogares disfuncionales sobre el desarrollo afectivo de los niños, en una muestra de 100 estudiantes del Séptimo Año de Educación General Básica, de la Unidad Educativa Milagro. La metodología utilizada fue cuantitativa, descriptiva y correlacional, y los instrumentos utilizados fueron la escala de clima, y la escala de afecto. Los resultados obtenidos indicaron que el 57,31%  apunta a la presencia de hogares disfuncionales, con un clima familiar caracterizado por 57,17% de no cohesión, el 58,38% de no expresividad y el 56,36% de conflictos, frente a un 42,69%, que afirman no padecer de disfuncionalidad. Y la variable desarrollo socio-afectivo, el 61, 09% de escolares evidenciaron falta de afecto y vinculo comunicativo, y el 38, 91% demostraron recibir amor en sus hogares, y en la dimensión de criticarechazo, el 53,28% percibieron malos tratos de sus padres, sin embargo el 46,72% no evidencia ningún tipo de acción. Todo esto llevó a saber que los escolares presentan un desarrollo socio-afectivo negativo en relación a la magnitud de un hogar disfuncional en el que se encuentran.

Abstract 

This research paper proposes the incidence of dysfunctional homes in the socio-affective development of school children, it is understood that within families the presence of conflicts may become part of a process, however these exacerbations of they are intensified in a series of negative situations that fall on the children of the home, the objective of this study is to identify the incidence of dysfunctional homes on the affective development of children, in a sample of 100 students of the Seventh Year of Education General Basic, of the Milagro Educational Unit. The methodology obtained was quantitative, descriptive and correlational, and the instruments integrated in the family climate scale, and the scale of affect. The results indicated that 57.31% corresponded to the presence of dysfunctional homes, with a family climate and 57.37% of noncohesion, 58.38% expressiveness and 56.36% of conflicts, compared to a 42.69%, who claim not to suffer from dysfunction. And the variable socio-affective development, 61, 09% of the students, evidence, lack of affection and communicative bond, and 38, 91%, demonstrate love in their homes, and the dimension of criticism and rejection, 53, 28%. However, 46.72% do not have any type of action. All this has a saber that schoolchildren a negative socio-affective development in the relation of the magnitude of a dysfunctional home in which they are.
Infections Prevention and Control (IPC) Programs in Hospitals
Authors: Safira Anis Rahmawati  , Inge Dhamanti
Published: April 2021

Healthcare Associated Infections (HAIs) atau infeksi nosokomial masih menjadi masalah yang paling sering terjadi pada pelayanan kesehatan. Rumah sakit perlu melaksanakan pencegahan dan pengendalian infeksi (PPI) sebagai standar mutu pelayanan rumah sakit serta untuk melindungi pasien, petugas kesehatan dan pengunjung dari kejadian infeksi yang tidak diharapkan. Pada kenyataannya, pelaksanaan program pencegahan dan pengendalian infeksi di berbagai rumah sakit belum terlaksana dengan baik. Penelitian ini menganalisis faktor yang mempengaruhi pelaksanaan program pencegahan dan pengendalian infeksi di rumah sakit. Penelitian ini menggunakan metode literature review dengan menggunakan 11 artikel yang berasal dari berbagai data sources. Hasil penelitian ini menunjukkan bahwa faktor yang memengaruhi pelaksanaan program pencegahan dan pengendalian infeksi di rumah sakit yaitu faktor fungsi manajemen, peran dan fungsi kepala ruangan, ketersediaan sarana dan prasarana, serta faktor budaya organisasi.
The Dominant factor of metabolic syndrome among office workers
Authors: Rahma Listyandini  , Fenti Dewi Pertiwi  , Dian Puspa Riana  , Widya Asih Lestari
Published: April 2021

The prevalence of metabolic syndrome in workers is high. Its impact can lower health status and disrupt work productivity. This research aimed to identify the dominant factor of metabolic syndrome among workers in government agencies of the Tanjung Priok port, Jakarta. The research method used descriptive- analytic with a cross-sectional design. The study used secondary data from medical check-up records of 256 workers in Port of Tanjung Priok. The inclusion criteria was all employees who had a medical check-up. Exclusion criteria was pregnancy and individuals with too much missing or poorly recorded information. The chi-square test and binary logistic regression were applied for analysis. The study found that metabolic syndrome prevalence was quite high in workers (38.7%). The results of a multivariate analysis showed physical activity (p = 0,003, OR = 2,238), total energy (P = 0,038, OR = 1,960), and carbohydrate intake (p = 0,014, OR = 0,490), together became the risk factor of the metabolic syndrome among workers. The dominant factor of metabolic syndrome was physical activity. The worker was susceptible to low physical activity so that the risk of metabolic syndrome was quite high. The company should improve the health promotion program in the workplace with regular screening, improved physical activity and provide a healthy meal to prevent metabolic syndrome in workers.
Lactobacillus and Bifidobacterium Bacteria Profile in Healthy People and People with Type 2 Diabetes Mellitus
Authors: Nurmalya Kardina Rizki , Yuliani Kartika , Nuriannisa Farah
Published: April 2021

Lactobacillus and Bifidobacterium are two genera of gram-positive bacteria that are widely used as probiotic products to improve the composition of the intestinal microbiota but until now the difference in the number of these bacteria in patients with type 2 diabetes mellitus and healthy people in Asia remains unclear. This study conducted a systematic review to analyze the differences in the number of Lactobacillus and Bifidobacterium bacteria in patients with type 2 diabetes and healthy people in Asia. The results showed that the number of Lactobacillus bacteria was higher in patients with type 2 diabetics than in healthy people. The number of Bifidobacterium bacteria in patients with type 2 diabetes tended to be lower than in healthy people, although there was some literature stating that there was no difference in the number of Bifidobacterium bacteria in patients with type 2 diabetes and in healthy people. Further research on the profile of Lactobacillus and Bifidobacterium bacteria per type (species) specifically in people with type 2 diabetes and healthy people of various ethnicities in Indonesia is needed to identify dysbiosis in people with type 2 diabetes and determine specific microbiota therapy for people with type 2 diabetes.
HbA1c Evidence for a Prediabetes Diagnosis Delays Onset of Type 2 Diabetes
Authors: Johnson Maurice , Fishbein Howard , Jeffries Birch Rebecca , Yu Qilu , Mardon Russ , Pace Wilson , Ritchie Natalie , Carroll Jennifer , Meeker Daniella
Published: April 2021

Objective: This study examined the influential role of making a prediabetes diagnosis resulting in the subsequent delay in onset of type 2 diabetes. Research Design and Methods: Using electronic medical records, a multivariable logistic regression model examined demographic and clinical risk factors associated with a prediabetes diagnosis among patients with HbA1c evidence of prediabetes. A multivariable non-proportional Cox regression examined development to type 2 diabetes (maximum 7 year follow-up). Results: Analysis includes 40,970 patients with incident prediabetes (76.8% undiagnosed). Logistic regression showed higher baseline HbA1c levels significantly influenced assigning a prediabetes diagnosis: compared to patients with HbA1c level 5.7-5.9% (low), OR 1.66 (99% CI 1.54-1.78) for HbA1c level 6.0-6.2% (medium) and OR 1.62 (CI 1.43-1.83) for HbA1c level 6.3-6.4% (high). Cox model results, which included an interaction between HbA1c and prediabetes diagnosis, found HbA1c the most significant predictor. Patients with diagnosed prediabetes progressed to type 2 diabetes slower than those undiagnosed. Comparing diagnosed patients to undiagnosed within the same HbA1c level, HRs ranged from 0.47 (CI 0.37-0.61) in the high HbA1c level to 0.83 (CI 0.67-1.02) in the low HbA1c level. Conclusions: From the LEADR cohort (1) HbA1c levels were the principle factor associated with risk for prediabetes diagnosis. Modeling development to diabetes, baseline HbA1c was the significant predictor of risk. Findings suggest assignment of a prediabetes diagnosis is associated with slower development of diabetes and this protective benefit of being diagnosed increases with a higher baseline HbA1c. Prediabetes diagnosis is useful for delaying onset of type 2 diabetes.
Implementasi metode weighted product pada sistem pendukung keputusan penerima beasiswa bidikmisi universitas mataram
Authors: Wahyudi Faraz
Published: April 2021

Pemberian beasiswa merupakan program kerja yang ada di setiap Universitas atau perguruan tinggi. Bidikmisi adalah program bantuan biaya pendidikan yang diberikan pemerintah melalui Direktorat Jenderal Pendidikan Tinggi. Dalam melakukan penetapan mahasiswa peserta beasiswa bidikmisi pihak Universitas masih menggunakan cara manual yaitu dengan cara melakukan pengecekan kembali data mahasiswa satu persatu di Microsoft excel oleh Subbagian Kesejahteraan Mahasiswa dan hasil seleksi data diurutkan berdasarkan fakultas atau prodi masing-masing. Untuk membantu dalam proses seleksi maka perlu dibangun sistem pendukung keputusan, agar dapat menjadi pertimbangan dalam mengambil keputusan. Dalam sistem pendukung keputusan ini menggunakan 10 kriteria antara lain: penghasilan ayah, penghasilan ibu, jumlah tanggungan, kepemilikan rumah, luas tanah, luas bangunan, jarak pusat kota, mandi cuci kakus, sumber listrik dan sumber air. Didalam sistem pendukung keputusan ini perhitungannya menggunakan metode weighted product. Metode weighted product digunakan karena metode ini lebih bisa memberikan nilai bobot disetiap kriteria kemudian dilakukan perangkingan dari yang terbesar ke terkecil dari hasil perhitungan nilai akhir. Dalam pembangunan sistem ini, menggunakan bahasa pemograman PHP dan database yang digunakan mysql dengan menggunakan framework Codeigniter.