bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Temperature Sintering on Grain Growth and Optical Properties of TiO2 Nanoparticles
Authors: Tsega Yihunie Moges
Published: April 2023

Titanium dioxide (TiO2) nanoparticles were prepared by the sol–gel method and the structural, morphological, and optical properties were investigated at different sintering temperatures of 500, 600, 700, 800, and 900°C. A tetragonal structure of anatase, mixed (anatase–rutile), and rutile phases are observed in the X-ray diffraction (XRD) analysis. Pure anatase phase formation occurred at 500°C, whereas anatase-to-rutile phase transformation began at 600°C, and reaching complete conversion to rutile at 800°C. The average crystallite size increased from 23 to 34 nm for anatase and 38 to 62 nm for the rutile when sintering temperature increased from 500 to 900°C. The scanning electron microscope (SEM) result presented the increase of grain size (25–100 nm) with increasing the sintering temperature. The Fourier transform infrared (FTIR) spectra demonstrated the presence of TiO2 vibrational bonds in all samples. The optical bandgaps of the sintered TiO2 nanoparticles decreased with rising sintering temperature. Photoluminescence spectra exhibited three characteristic peaks centered at 380, 450, and 550 nm. The emission intensity increased with increasing the sintering temperature. The Mie analysis was also studied to calculate scattering cross-section, forward scattering, and asymmetry for different grain sizes. The results showed that by increasing the nanoparticle diameters, the peaks of all spectra are redshifted for larger grain sizes and cross-section peaks shift to high values. In this study, the sintering temperature is observed to have a strong influence on crystalline phase transformation, microstructure, and optical properties of TiO2 nanoparticles. The TiO2 sample sintered at 900°C shows the best result to be used as luminescent material due to the low optical bandgap energy.
Supply Chain Management (SCM) Breakdowns and SCM Strategy Selection during the COVID-19 Pandemic Using the Novel Rough MCDM Model
Authors: Stević Željko , Ulutaş Alptekin , Korucuk Selçuk , Memiş Salih , Demir Ezgi , Topal Ayşe , Karamaşa Çağlar
Published: April 2023

Supply chain management (SCM) is deeply affected by the COVID-19 pandemic besides breakdowns occurred in all sectors. Nowadays, managers need techniques for protecting supply chains from serious and costly disruptions, establishing permanent relationships with the customers and partners and preventing breakdowns throughout the process. Each firm needs to determine SCM strategies to be prepared for breakdowns in an intense competitive environment. With COVID-19, the change in business and trade environments has taken a different dimension, and it has revealed a new relationship between the efforts to perpetuate supply chains and strategies for supply chain management and enabled new models. In this study, it is aimed to prioritize the factors that lead to SCM breaks needed in project management and the realization of projects, and to choose the most successful SCM strategy considering COVID-19. For this purpose, rough SWARA was used for weighting factors and rough MARCOS was used for the alternative selection. According to the findings, the transportation capacity factor was found to be the most important factor leading to SCM breakdowns. The most ideal supply chain management strategy has been the “collaborative supply chain management strategy.” In the food manufacturing sector, the study can be considered as a roadmap in terms of preventing supply chain management breaks during the COVID-19 process and helping to ensure a sustainable production. As another theoretical and practical importance of the study, it is aimed to propose a robust, powerful, and practical decision-making model that can cope with the current uncertainties.
[Retracted] Analysis of the Clinical Effect of Visual Electrophysiological Examination Combined with Targeted Health Education Nursing in Children
Authors: Qiu Yanan , Xiong Lan
Published: April 2023

Objective. To analyze the clinical effect of visual electrophysiological examination combined with targeted health education nursing in children. Methods. A total of 100 children who underwent visual electrophysiological examinations in the Ophthalmology Department of our hospital from March 2019 to March 2021 were selected as the study subjects. The children were randomly divided into two groups, the control group and the observation group, with 50 children in each group. Children in the control group received routine nursing, while those in the observation group received a combination of routine nursing and targeted health education nursing. The nursing satisfaction, degree of cooperation with examination, examination time, changes in the psychological state, and the stress response of the children and their families were then compared and analyzed. Results. The nursing satisfaction of the observation group was higher than that of the control group (94.0% vs. 80.0%) (P < 0.05). The degree to which children in the observation group cooperated with examination was higher than that of children in the control group (96.0% vs. 78.0%) (P < 0.05). The average time spent on VEP and ERG examinations by children in the observation group was 6.33 ± 1.37 hours and 55.25 ± 4.92 hours, respectively, significantly lower than that of 12.45 ± 1.02 hours and 70.36 ± 5.31 hours, respectively, spent by children in the control group (P < 0.05). After intervention, the depression, hostility, anxiety, and obsession scores of children in the observation group were all significantly lower than those of children in the control group (P < 0.05). There was an increase in the heart rate, respiratory rate, and mean arterial pressure in children from both groups, but the magnitude of increase in the observation group was much smaller than that in the control group (P < 0.05). Conclusion. The combination of visual electrophysiological examination and targeted health education nursing in children has a remarkable clinical effect. It improves the children’s degree of comfort as well as the parents’ degree of satisfaction. It also reduces the time spent on examinations, facilitates the smooth completion of examinations, and improves the efficiency of examinations. This nursing method is one that merits more widespread promotion and clinical application.
Blood Donation Knowledge, Perceptions, and Practices during COVID‐19 Pandemic: Questionnaire‐Based Study in Saudi Arabia
Authors: Waggiallah Hisham Ali
Published: April 2023

Background and Objective. Blood transfusion is an essential service for health systems all over the world, which struggle on a regular basis to strike a balance between public needs and the amount of donated blood available. The purpose of this study is to assess blood donation awareness, perception, and concepts during the COVID‐19 pandemic. Material and Methods. Electronic questionnaires were used to reach out to various categories of the population. The total sample size for the current study was 314 participants. A standardized questionnaire that had been pretested was used to collect data. The first section of the questionnaire includes variables relating to the study participants’ sociodemographic characteristics. The second half, on the other hand, included knowledge, attitudes, and practices (KAP) questions about blood donation during coronavirus disease 19 (COVID‐19). Results. The level of good knowledge of the blood donation process and perceptions constituted more than 52.2% and 52.9%, respectively, of the participants. The biggest motivation for the donation process was the awareness campaigns, which amounted to 52.5%, and the biggest obstacle to the blood donation procedure is the lack of health fitness. It has been found that 43.0% of those who completed the questionnaire had donated blood during the COVID‐19 pandemic. Conclusion. Though the high level of awareness of the importance of blood donation for COVID‐19 patients, as well as the satisfaction with the experience of blood donation for patients, the level of general knowledge remains average.
Real-Time Continuous Glucose Monitoring Reduced Costly Diabetes-Related Events in Adolescents and Young Adults despite Lack of Short-Term Reduction in Hemoglobin A1c
Authors: Beck Joni K. , Allen Rebecca A. , Jeter Kathryn M. , Fisher Rachel S. , Dattilo Taylor M. , Traino Katherine A. , Anderson Michael , Cutler James , Sparling David P.
Published: April 2023

Real-time continuous glucose monitoring (rtCGM) can directly improve patient outcomes, including decreased health care system utilization and associated costs. The purpose of this study was to evaluate the clinical benefits of rtCGM use in a high-risk, under-resourced cohort of adolescents and young adults (AYA) with type 1 diabetes (T1D) who had no prior access to rtCGM. The effects of rtCGM use on hemoglobin A1c (A1c) and the frequency of health care events (i.e., diabetes-related emergency room (ER) visits, hospitalizations, emergency medical services (EMS), and after-hour emergency calls) were evaluated regarding payor costs in 33 AYA with ≥70% rtCGM use. Secondary aims included the evaluation of a phone-based pattern management intervention. The frequency of health care events decreased at 12 and 24 weeks for all participants, and there was no significant difference by treatment group. We estimated that the use of rtCGM in this cohort results in a projected annualized cost-savings of $195,943 to $294,864 or 43–65% per year based on Medicare or list pricing for rtCGM, respectively. Results also revealed improvements in A1c at 12 weeks for all study participants, but this was not maintained at 24 weeks for the phone-based pattern management intervention group. Our findings suggest that rtCGM may be an effective tool for reducing diabetes-related events and underscores the importance of access. Future studies are needed to further examine tailored interventions and support to optimize rtCGM use and glycemic health in high-risk AYA.
Self-Determination Theory and Quality of Life of Adults with Diabetes: A Scoping Review
Authors: Sarfo Jacob Owusu , Obeng Paul , Kyereh Henneh Kwaku , Ansah Edward Wilson , Attafuah Priscilla Yeye Adumoah
Published: April 2023

Background. Diabetes is one of the leading causes of sickness, death, and decreased quality of life globally. The prevalence of diabetes keeps rising globally due to lifestyle changes and urbanization. Therefore, improved quality of life (QoL) and appropriate diabetes self-management practices, including treatment adherence, are crucial to improving and sustaining the health of diabetic patients. Some studies have adopted the self-determination theory (SDT) to study diabetes interventions, but less is known about its effectiveness in improving QoL, treatment adherence, and diabetes self-management. Aim/Objective. This review assessed the effectiveness of SDT in improving self-management practices, treatment adherence, and QoL among adult diabetic patients. Method. We followed the six-stage framework by Arksey and O’Malley in conducting the review. PubMed, JSTOR, Central, and ScienceDirect databases were searched for published articles from January 2011 to October 2021 using keywords and Boolean logic. Furthermore, we screened a reference list of related articles. Also, Google Scholar, Z-library, and web-based searches were carried out to retrieve other relevant evidence that applied SDT in improving QoL, diabetes self-management, and treatment adherence. Findings. Fifteen studies met the inclusion criteria, from which data were extracted as findings. SDT effectively improved QoL, diabetes treatment adherence, and diabetes self-management among diabetic patients. Of these studies, 11 provided data on SDT and diabetes self-management and affirmed the effectiveness of the theory in improving appropriate diabetes self-management practices. Two studies confirmed the effectiveness of SDT in improving treatment adherence. SDT and QoL were assessed in 4 of the studies, which demonstrated the effectiveness of SDT in enhancing the QoL of diabetic patients. Conclusion. SDT effectively improved QoL, diabetes treatment adherence, and diabetes self-management. The application of SDT in diabetes management will improve the health and QoL of diabetic patients. Hence, diabetes management interventions could adopt SDT to guide treatment.
Effect of Real-Time Environment on Mechanical Properties of Preformed Stainless Steel Archwires: An In Vivo Study
Authors: Pai Divya , Urala Arun S. , Ginjupalli Kishore , Pentapati Kalyana Chakravarthy , Agrawal Gaurav
Published: April 2023

Introduction. Clinicians should be aware of any effect the oral environment may have on archwires. Laboratory models fail to closely imitate intraoral conditions. The aim was to evaluate the change in mechanical properties of preformed stainless steel archwires after 15 weeks of exposure to the oral environment. Methods. Three commercially manufactured 0.019 × 0.025″ stainless steel archwires were evaluated. Young’s modulus, yield strength, spring factor, and hardness were studied. The unexposed distal end cuts (control samples) and archwires were tested after 15 weeks of intraoral exposure (test samples). Tension tests, Vickers microhardness tests, and nanoindentation tests were carried out. Results. Normality was tested using the Shapiro–Wilk test. Statistical analyses included the paired t-test for intragroup comparisons and Kruskal–Wallis ANOVA with the post hoc Dunn test for comparison of mean percentage reduction in values. At T15, Young’s modulus showed a statistically significant decrease. Changes in yield strength and spring factor were not significant for groups other than American Orthodontics wires. The reduction in hardness was significant in 3M Unitek. Vickers, tension, and nanoindentation tests demonstrated an expansive range between hardness and Young’s modulus so determined. Conclusion. 3M Unitek archwires showed the highest difference in Young’s modulus. Yield strength values increased in Ortho Organizers archwires. Spring factor decreased only in 3M Unitek archwires. Hardness values obtained from various tests did not produce identical results.
MAML2-Rearranged Primary Central Mucoepidermoid Carcinoma of the Mandible as an Incidental Finding: A Case Report and Review of the Literature of Molecularly Confirmed Cases
Authors: Aguirre Sarah E. , Tyler Donald , Owosho Adepitan A.
Published: April 2023

This report presents an extremely rare case of MAML2-rearranged primary central mucoepidermoid carcinoma (MEC) of the mandible that was discovered as an incidental finding. Our review of the literature identified 36 cases of MAML2-rearranged intraosseous lesions of the jaw (30 central MECs, 5 odontogenic cysts with mucous prosoplasia, and 1 glandular odontogenic cyst). Given the therapeutic indications for a diagnosis of MEC (a malignant neoplasm), MAML2 rearrangement should be confirmed in suspected cases of central MEC.
Fishmeal Protein Replacement by Defatted and Full-Fat Black Soldier Fly Larvae Meal in Juvenile Turbot Diet: Effects on the Growth Performance and Intestinal Microbiota
Authors: Zhao Jingjing , Pan Jintao , Zhang Zhonghao , Chen Zhichu , Mai Kangsen , Zhang Yanjiao
Published: April 2023

A 12-week feeding trial was conducted to investigate the effect of the same fishmeal protein level replaced by black soldier fly larvae (Hermetia illucens) meal (BSFL) with different lipid contents on the growth performance and intestinal health of juvenile turbot (Scophthalmus maximus L.) (initial body weight 12.64 g). Three isonitrogenous and isolipidic diets were formulated: fish meal-based diet (FM), diets DF and FF, in which 14% fish meal protein of the FM diet was replaced by defatted and full-fat BSFL, respectively. There were no significant differences in growth performance, intestinal morphology, and mucosal barrier function between the DF and the FM group. However, diet FF markedly reduced the growth performance, intestinal perimeter ratio, and the gene expression of anti-inflammatory cytokine TGF-β (

P
<
0.05

). Compared to group FF, the communities of intestinal microbiota in group DF were more similar to group FM. Moreover, diet DF decreased the abundance of some potential pathogenic bacteria and enriched the potential probiotics, such as Bacillus. Diet FF obviously altered the composition of intestinal microbiota and increased the abundance of some potential pathogenic bacteria. These results suggested that the application of defatted BSFL showed more positive effects on fish growth and intestinal health than the full-fat BSFL, and the intestinal microbiota was closely involved in these effects.
Experiment and Numerical Simulation of Strength and Stress Distribution Behaviors of Anchored Rock Mass in a Roadway
Authors: Zhao Honghui , Su Haijian , Qin Xiaofeng , Zhang Kai , Jiang Yu , Wang Wenbo
Published: April 2023

Due to the influence of the ground stress, mining disturbance, and other factors, the roadway surrounding rock in deep underground engineering such as mines, tunnels, and underground caverns is prone to looseness and deformation with the excavation of roadways. In such engineering, the bolt support is frequently employed to stabilize the surrounding rock. In this work, a part of the anchor and the surrounding rock were taken as a simplified model of the anchorage rock mass, and the laboratory compression test was performed on the similitude model. Then, the FLAC3D software was used to simulate varying numbers of bolts and different lateral pressure conditions, and the peak stress, the maximum principal stress field, and the anchor stress field distribution of the anchorage rock mass were obtained. The influence of bolt pretightening force and row spacing on the stability of surrounding rock was discussed using the combined arch theory. The results show that increasing the number of bolts and lateral pressure in the anchorage rock mass can significantly improve the stress value and distribution range of the maximum principal stress field and the anchorage stress field. The fluctuation of the anchorage stress field at different anchorage distances can be lessened by increasing the number of bolts (bolt density). When the lateral pressure exceeds 3 MPa, the anchorage mechanical characteristics of the anchorage rock mass tend to remain stable. The coverage of the effective anchorage stress field and the thickness of the surrounding rock anchorage composite arch can be increased by increasing the bolt pretightening force and decreasing row spacing, consequently improving the anchorage mechanical characteristics of the anchorage rock mass. The research results can be used as a theoretical reference for choosing appropriate bolt support parameters for the roadway surrounding rock.
A Novel Variant in VPS13B Underlying Cohen Syndrome
Authors: Hussain Abrar , Acharya Anushree , Bharadwaj Thashi , Genomics University Of Washington Center For Mendelian , Leal Suzanne M. , Khaliq Abdul , Mir Asif , Schrauwen Isabelle
Published: April 2023

Pathogenic variants in vacuolar protein sorting 13 homolog B (VPS13B) cause Cohen syndrome (CS), a clinically diverse neurodevelopmental disorder. We used whole exome and Sanger sequencing to identify disease‐causing variants in a Pakistani family with intellectual disability, microcephaly, facial dysmorphism, neutropenia, truncal obesity, speech delay, motor delay, and insomnia. We identified a novel homozygous nonsense variant c.8841G > A: p.(W2947 ∗) in VPS13B (NM_017890.5) which segregated with the disease. Sleep disturbances are commonly seen in neurodevelopmental disorders and can exacerbate medical issues if left untreated. We demonstrate that individuals with Cohen syndrome may also be affected by sleep disturbances. In conclusion, we expand the genetic and phenotypic features of Cohen syndrome in the Pakistani population.
Supplementary Information from Prostate Cancer Risk Stratification via Nondestructive 3D Pathology with Deep Learning–Assisted Gland Analysis
Authors: Xie Weisi , Reder Nicholas P. , Koyuncu Can , Leo Patrick , Hawley Sarah , Huang Hongyi , Mao Chenyi , Postupna Nadia , Kang Soyoung , Serafin Robert , Gao Gan , Han Qinghua , Bishop Kevin W. , Barner Lindsey A. , Fu Pingfu , Wright Jonathan L. , Keene C. Dirk , Vaughan Joshua C. , Janowczyk Andrew , Glaser Adam K. , Madabhushi Anant , True Lawrence D. , Liu Jonathan T.C.
Published: April 2023

Supplementary methods, notes, figures, tables, video captions, and references
Supplementary Table 4 from Low-Carbohydrate Diet Score and the Risk of Colorectal Cancer: Findings from the Singapore Chinese Health Study
Authors: Yu Yi-Chuan , Paragomi Pedram , Jin Aizhen , Wang Renwei , Schoen Robert E. , Koh Woon-Puay , Yuan Jian-Min , Luu Hung N.
Published: April 2023

Supplementary Table S4 describes results from models without BMI variable adjustment (stratified analysis)
Supplementary Table 1 from Low-Carbohydrate Diet Score and the Risk of Colorectal Cancer: Findings from the Singapore Chinese Health Study
Authors: Yu Yi-Chuan , Paragomi Pedram , Jin Aizhen , Wang Renwei , Schoen Robert E. , Koh Woon-Puay , Yuan Jian-Min , Luu Hung N.
Published: April 2023

Supplementary Table S1 describes baseline characteristics of participants
Supplementary Table 6 from Associations between MICA and MICB Genetic Variants, Protein Levels, and Colorectal Cancer: Atherosclerosis Risk in Communities (ARIC)
Authors: Wang Shuo , Onyeaghala Guillaume C. , Pankratz Nathan , Nelson Heather H. , Thyagarajan Bharat , Tang Weihong , Norby Faye L. , Ugoji Chinenye , Joshu Corinne E. , Gomez Christian R. , Couper David J. , Coresh Josef , Platz Elizabeth A. , Prizment Anna E.
Published: April 2023

Supplemental Table 6 shows the associations of sMICA and sMICB levels (continuous variables) and pre-selected SNPsb with risk of CRC and subtypes of CRC.
Supplementary Table 4 from Associations between MICA and MICB Genetic Variants, Protein Levels, and Colorectal Cancer: Atherosclerosis Risk in Communities (ARIC)
Authors: Wang Shuo , Onyeaghala Guillaume C. , Pankratz Nathan , Nelson Heather H. , Thyagarajan Bharat , Tang Weihong , Norby Faye L. , Ugoji Chinenye , Joshu Corinne E. , Gomez Christian R. , Couper David J. , Coresh Josef , Platz Elizabeth A. , Prizment Anna E.
Published: April 2023

Supplemental Table 4 shows the associations of Visit 2 sMICA and sMICB levels (in quartiles) with CRC risk.
Table S2 from Trend in Cervical Cancer Incidence and Mortality Rates in China, 2006–2030: A Bayesian Age-Period-Cohort Modeling Study
Authors: Yuan Meiwen , Zhao Xuelian , Wang Honghao , Hu Shangying , Zhao Fanghui
Published: April 2023

Table S2 shows trends for age-specific cervical cancer incidence and mortality rates by region in China between 2006 to 2016.
Table S1 from Trend in Cervical Cancer Incidence and Mortality Rates in China, 2006–2030: A Bayesian Age-Period-Cohort Modeling Study
Authors: Yuan Meiwen , Zhao Xuelian , Wang Honghao , Hu Shangying , Zhao Fanghui
Published: April 2023

Table S1 shows average age and standardized average age at diagnosis for cervical cancer between 2006 to 2030.
Supplemental Table 5 from Measurement of Ovarian Tumor Immune Profiles by Multiplex Immunohistochemistry: Implications for Epidemiologic Studies
Authors: Hathaway Cassandra A. , Conejo-Garcia Jose R. , Fridley Brooke L. , Rosner Bernard , Saeed-Vafa Daryoush , Moran Segura Carlos , Nguyen Jonathan V. , Hecht Jonathan L. , Sasamoto Naoko , Terry Kathryn L. , Tworoger Shelley S. , Townsend Mary K.
Published: April 2023

Supplemental Table 5 shows beta binomial models, odds ratios and 95% confidence intervals for marker positivity in the tumor, by population characteristics
Supplemental Table 4 from Measurement of Ovarian Tumor Immune Profiles by Multiplex Immunohistochemistry: Implications for Epidemiologic Studies
Authors: Hathaway Cassandra A. , Conejo-Garcia Jose R. , Fridley Brooke L. , Rosner Bernard , Saeed-Vafa Daryoush , Moran Segura Carlos , Nguyen Jonathan V. , Hecht Jonathan L. , Sasamoto Naoko , Terry Kathryn L. , Tworoger Shelley S. , Townsend Mary K.
Published: April 2023

Supplemental Table 4 shows beta binomial models, odds ratios and 95% confidence intervals for marker positivity in the tumor, by tumor and participant characteristics
Supplemental Table 2 from Measurement of Ovarian Tumor Immune Profiles by Multiplex Immunohistochemistry: Implications for Epidemiologic Studies
Authors: Hathaway Cassandra A. , Conejo-Garcia Jose R. , Fridley Brooke L. , Rosner Bernard , Saeed-Vafa Daryoush , Moran Segura Carlos , Nguyen Jonathan V. , Hecht Jonathan L. , Sasamoto Naoko , Terry Kathryn L. , Tworoger Shelley S. , Townsend Mary K.
Published: April 2023

Supplemental Table 2 shows the distribution of presence/absence of percentage of the marker in the tumor, by age of sample for type I and type II tumors
Figure S2 from PSMA-positive Circulating Tumor Cell Detection and Outcomes with Abiraterone or Enzalutamide Treatment in Men with Metastatic Castrate-resistant Prostate Cancer
Authors: Gupta Santosh , Halabi Susan , Yang Qian , Roy Akash , Tubbs Alisa , Gore Yamini , George Daniel J. , Nanus David M. , Antonarakis Emmanuel S. , Danila Daniel C. , Szmulewitz Russell Z. , Wenstrup Richard , Armstrong Andrew J.
Published: April 2023

Kaplan Meier plots depict the association between PSMA+ CTC enumeration and OS and PFS. The associations of PSMA+ CTC enumeration with overall survival (OS) and progression-free survival (PFS) were explored using the proportional hazard model. A) The median OS in months for CTC=0 (reference), CTC+ PSMA-CTC, CTC+ PSMA+CTC but heterogeneous (<100%), and CTC+ PSMA+ 100% (homogeneous), respectively, were 25.7 (95% CI=19.8-NR), 24.5 (95% CI=16.7-30.4),15.6 (95% CI=14.4-20.7), and 35.0 (95% CI=16.9-NA). Univariate hazard ratio (HR) was 1.3 (95% CI=0.7-2.6), 2.0 (95% CI=1.0-3.8) and 0.7; 95% CI = 0.2-2.1 for CTC+, PSMA-CTC, CTC+ PSMA CTC+ but heterogeneous (<100%), and CTC+ PSMA+ 100% (homogeneous) vs. CTC=0, respectively. B) The median PFS for CTC=0 (reference), CTC+, PSMA-CTC, CTC+ PSMA+ CTC but heterogeneous (<100%), and CTC+ PSMA+ 100%, respectively, were 7.6 (95% CI=6.7-16.5), 6.0 (95% CI=3.5-11.4),5.5 (95% CI=3.6-7.6), and 5.7 (95% CI=3.0-NA). Univariate HR was 1.4 (95% CI=0.8-2.6), 2.0 (95% CI=1.1-3.6) and 1.5; 95% CI = 0.7-3.6 for CTC+, PSMA-CTC, CTC+ PSMA+ CTC but heterogeneous (<100%), and CTC+ PSMA+ 100% (homogeneous) vs. CTC=0, respectively.
Figure S1 from PSMA-positive Circulating Tumor Cell Detection and Outcomes with Abiraterone or Enzalutamide Treatment in Men with Metastatic Castrate-resistant Prostate Cancer
Authors: Gupta Santosh , Halabi Susan , Yang Qian , Roy Akash , Tubbs Alisa , Gore Yamini , George Daniel J. , Nanus David M. , Antonarakis Emmanuel S. , Danila Daniel C. , Szmulewitz Russell Z. , Wenstrup Richard , Armstrong Andrew J.
Published: April 2023

PSMA protein expression distribution from men with mCRPC at a single cell CTC level before (baseline, N= 97) and after (progression, N= 57) abiraterone or enzalutamide therapy.
Figure S2 from UBE2C-mediated Autophagy Inhibition via Ubiquitination of SIRT1 Contributes to Endometrial Cancer Progression
Authors: Zhao Rong , Liu Yan , Wang Ziwei , Zhang Jun , Zhang Wei , Zhou Xing , Tsedendorj Sevjid , Enkhtur Amarsanaa , Feng Dilu , Wang Hongbo
Published: April 2023

Figure S2
Figure S4 from Interdependence of SS18-SSX–driven YAP1 and β-Catenin Activation in Synovial Sarcoma
Authors: Isfort Ilka , Berthold Ruth , Heinst Lorena , Wardelmann Eva , Larsson Olle , Trautmann Marcel , Hartmann Wolfgang
Published: April 2023

Figure S4 shows that induction of hyperactive YAP1/TAZ or β-catenin variants does not alter the other's protein levels.
Figure S1 from Interdependence of SS18-SSX–driven YAP1 and β-Catenin Activation in Synovial Sarcoma
Authors: Isfort Ilka , Berthold Ruth , Heinst Lorena , Wardelmann Eva , Larsson Olle , Trautmann Marcel , Hartmann Wolfgang
Published: April 2023

Figure S1 shows that the SS18-SSX fusion protein regulates TEAD- and TCF-mediated transcriptional activity, both being important for SySa cell viability.
Supplementary Figures 1-8 from FOXA1 Reprogramming Dictates Retinoid X Receptor Response in ESR1-Mutant Breast Cancer
Authors: Wu Yang , Li Zheqi , Wedn Abdalla M. , Casey Allison N. , Brown Daniel , Rao Shalini V. , Omarjee Soleilmane , Hooda Jagmohan , Carroll Jason S. , Gertz Jason , Atkinson Jennifer M. , Lee Adrian V. , Oesterreich Steffi
Published: April 2023

S1. FOXA1 redistribution in ESR1 mutant cells causes distinct ER-FOXA1 interaction.S2. FOXA1 gained peaks annotated genes are significantly associated with novel target genes.S3. FOXA1 redistribution in ESR1 mutant cells confers potential RXR binding sites.S4. RXR agonist LG100268 can promote colonization and growth of ESR1 mutant cells.S5. Clonogenic survival assay and 2D growth assay to test RXR response in Park and Gertz MCF7 cell models.S6. FOXA1 knockdown drastically attenuated the base line growth of both ESR1 WT and mutant cells.S7. RXR antagonist HX531 can inhibit the response of ESR1 mutant cells to RXR agonist.S8. RXR antagonist HX531 can inhibit the basal and agonist promoted growth of IPM-PDXO-073 organoid.
Supplementary Text and Tables from Myeloid-Derived Suppressor–Cell Dynamics Control Outcomes in the Metastatic Niche
Authors: Kreger Jesse , Roussos Torres Evanthia T. , MacLean Adam L.
Published: April 2023

Supplementary Text and Tables
Supplementary Figures from Netrin-1 Promotes the Immunosuppressive Activity of MDSCs in Colorectal Cancer
Authors: Xia Xueli , Mao Zhenwei , Wang Wenxin , Ma Jie , Tian Jie , Wang Shengjun , Yin Kai
Published: April 2023

Supplementary Figures S1-S9
Supplementary Figure S4 from Mitochondrial metabolism drives low-density lipoprotein-induced breast cancer cell migration
Authors: Nóbrega-Pereira Sandrina , Santos Francisco , Santos Miguel Oliveira , Serafim Teresa L. , Patrícia Lopes Ana , Coutinho Diogo , Carvalho Filipa S. , Domingues Rosário M. , Domingues Pedro , Bernardes de Jesus Bruno , Morais Vanessa A , Dias Sérgio
Published: April 2023

Lipid exposure induces metabolic and bioenergetic dependencies in breast cancer cells. Related to Fig. 4
Supplementary Figure S1 from Mitochondrial metabolism drives low-density lipoprotein-induced breast cancer cell migration
Authors: Nóbrega-Pereira Sandrina , Santos Francisco , Santos Miguel Oliveira , Serafim Teresa L. , Patrícia Lopes Ana , Coutinho Diogo , Carvalho Filipa S. , Domingues Rosário M. , Domingues Pedro , Bernardes de Jesus Bruno , Morais Vanessa A , Dias Sérgio
Published: April 2023

LDL-exposed breast cancer cells show differential invasion potential and metastatic tropism to distant sites in xenotransplanted zebrafish larvae at 4dpi (6dpf). Related to Fig. 1.
Supplementary Table S1 from Structurally Complex Osteosarcoma Genomes Exhibit Limited Heterogeneity within Individual Tumors and across Evolutionary Time
Authors: Rajan Sanjana , Zaccaria Simone , Cannon Matthew V. , Cam Maren , Gross Amy C. , Raphael Benjamin J. , Roberts Ryan D.
Published: April 2023

Characteristics of patient samples used in this study
Supplementary Figure S8 from Structurally Complex Osteosarcoma Genomes Exhibit Limited Heterogeneity within Individual Tumors and across Evolutionary Time
Authors: Rajan Sanjana , Zaccaria Simone , Cannon Matthew V. , Cam Maren , Gross Amy C. , Raphael Benjamin J. , Roberts Ryan D.
Published: April 2023

Bulk data genome SCNA plots by patient
Supplementary Figure S6 from Structurally Complex Osteosarcoma Genomes Exhibit Limited Heterogeneity within Individual Tumors and across Evolutionary Time
Authors: Rajan Sanjana , Zaccaria Simone , Cannon Matthew V. , Cam Maren , Gross Amy C. , Raphael Benjamin J. , Roberts Ryan D.
Published: April 2023

TP53 copy number in single-cell data
Supplementary Figure S2 from Structurally Complex Osteosarcoma Genomes Exhibit Limited Heterogeneity within Individual Tumors and across Evolutionary Time
Authors: Rajan Sanjana , Zaccaria Simone , Cannon Matthew V. , Cam Maren , Gross Amy C. , Raphael Benjamin J. , Roberts Ryan D.
Published: April 2023

CHISEL output plots
Notas sobre a ofiologia neotrópica e brasilica - III
Authors: Amaral Afrânio do
Published: April 2023

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Lista de moluscos do nordeste, com um apendice sôbre algumas espécies de outras regiões
Authors: Lucena Durval Tavares de
Published: April 2023

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O gênero Myoxomorpha White, 1855, e descrição de uma nova espécie
Authors: Prosen Alberto F. , Lane Frederico
Published: April 2023

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Cidades litorâneas paulistas, cidades hospitaleiras? Identificando conceitos de hospitalidade nos Planos Diretores das cidades turísticas do Estado de São Paulo v. 3
Authors:   Universidade de São Paulo. Faculdade de Arquitetura e Urbanismo, Severini Valéria Ferraz , Panosso Netto Alexandre ,   Universidade de São Paulo. Escola de Artes, Ciências e Humanidades
Published: April 2023

ste é o Volume 3 da Coleção Desenvolvimento do Turismo, do Programa de Pós-Graduação em Turismo da EACH-USP. A obra explora o tema da hospitalidade que permeia de diversas formas o turismo de qualidade e serve de base às atividades de gestão pública das cidades e espaços turísticos. Os autores desenvolveram a obra em torno do objetivo central de identificar e analisar como e onde os conceitos da hospitalidade urbana podem ser incorporados em Planos Diretores de cidades turísticas. Buscou-se discutir a hospitalidade da cidade e na cidade. Além de abordar questões de ordem política e prática, a obra também apresenta procedimentos metodológicas e diretrizes didáticas.
Association Between Genetic Diagnosis and Clinical Outcomes in Patients With Heritable Thoracic Aortic Disease
Authors: Yagyu Takeshi , Noguchi Teruo , Asano Yoshihiro , Ida Kazufumi , Ogata Soshiro , Nishimura Kunihiro , Matsuda Hitoshi
Published: April 2023

Background

Differences in the clinical course of heritable thoracic aortic disease based on the disease‐causing gene have not been fully evaluated. To clarify the clinical relevance of causative genes in heritable thoracic aortic disease, we assessed the clinical course of patients categorized based on genetic diagnosis.

Methods and Results

We investigated cardiovascular events and mortality in 518 genetically diagnosed patients in 4 groups: Group 1,
FBN1
(n=344); Group 2,
TGFBR1
,
TGFBR2
,
SMAD3
, or
TGFB2
(n=74); Group 3,
COL3A1
(n=60); and Group 4,
ACTA2
or
MYH11
(n=40). The median age at the first cardiovascular event ranged from 30.0 to 35.5 years (
P
=0.36). Patients with gene variants related to transforming growth factor‐β signaling had a significantly higher rate of subsequent events than those with
FBN1
variants (adjusted hazard ratio, 2.33 [95% CI, 1.60–3.38];
P
<0.001). Regarding the incidence of aortic dissection, there were no significant differences among the 4 groups in male patients (36.3%, 34.3%, 21.4%, and 54.2%, respectively;
P
=0.06). Female patients with
COL3A1
variants had a significantly lower incidence than female patients in the other 3 groups (34.2%, 59.0%, 3.1%, and 43.8%, respectively;
P
<0.001).

Conclusions

Gene variants related to transforming growth factor‐β signaling are associated with a higher incidence of subsequent cardiovascular events than
FBN1
variants.
COL3A1
variants might be related to a lower incidence of aortic dissection than other gene variants in women only. Identifying the genetic background of patients with heritable thoracic aortic disease is important for determining appropriate treatment.
Diagnosis of chylous abdominal effusions: what is the triglyceride threshold value?
Authors: Curis Emmanuel , Lefrère Bertrand , Bittar Randa , Levasseur Antoine , Grès Pierre , Guilbert Zoé , Zenati Belkacem , Cherfils Corinne , Sakka Mehdi , Bonnefont-Rousselot Dominique
Published: April 2023

IntroductionChylous abdominal effusions are serious complications that can be triggered by various aetiologies. The biochemical diagnosis of chyle leakage in ascites or in peritoneal fluid capsules relies on the detection of chylomicrons. Assaying the fluid’s concentration of triglycerides is still the first-line tool. Given that only one comparative study has sought to quantify the value of the triglyceride assay for diagnosing chylous ascites in humans, our objective was to provide practical triglyceride thresholds.
Materials and methodsWe conducted a 9-year, retrospective, single-centre study of adult patients and compared a triglyceride assay with lipoprotein gel electrophoresis for the analysis of 90 non-recurring abdominal effusions (ascites and abdominal collections) of which 65 were chylous.
ResultsA triglyceride threshold of 0.4 mmol/L was associated with a sensitivity > 95%, and a threshold of 2.4 mmol/L was associated with a specificity > 95%. According to Youden index, the best threshold was 0.65 mmol/L with a sensitivity of 88 (77-95)%, a specificity of 72 (51-88)%, and, in our series, a positive predictive value of 89 (79-95)% and a negative predictive value of 69 (48-86)%.
ConclusionsIn our series, cut-off of 0.4 mmol/L could be used for ruling-out diagnosis of chylous effusions, while cut-off of 2.4 mmol/L could be used for reasonably confirming diagnosis.
Misconceptions in Science
Authors: Malaterre Christophe , Javaux Emmanuelle J. , López-García Purificación
Published: April 2023

Disagreement in science exists in a variety of strengths, from doubt-raising articles and issues of non-reproducibility up to raging disputes and major controversies. An often-latent form of disagreement consists of misconceptions whereby false ideas are held that run contrary to what is commonly accepted as knowledge. Misconceptions have been the focus of much research in education science and psychology. Here we draw attention to misconceptions that may arise in the very practice of science. We highlight formal features that can be used to characterize misconceptions and distinguish them from controversies, in addition to how they relate to knowledge creation.
The Promises of Complexity Sciences: A Critique
Authors: Li Vigni Fabrizio
Published: April 2023

Complexity sciences have become famous worldwide thanks to several popular books that served as echo chambers of their promises. These consisted in departing from “classical science” defined as deterministic, reductionist, analytic and mono-disciplinary. Their founders and supporters declared that complexity sciences were going to give rise (or that they have given rise) to a post-Laplacian, antireductionist, holistic and interdisciplinary approach. By taking a closer look at their content and practices, I argue in this article that, because of their physics-oriented, computationalist, and mathematical assumptions, complexity sciences have paradoxically produced knowledge at odds with these four tenets.
Societal Impact in Research Collaborations beyond the Boundaries of Science
Authors: Koskinen Inkeri
Published: April 2023

Research collaborations beyond the boundaries of science—such as transdisciplinary, participatory or co-research projects—usually aim at increasing the societal impact of the research conducted. In the literature discussing such collaborations, as well as in science policy endorsing them, it is generally assumed that the wanted societal impact is achieved through exchange that contributes to knowledge production and to the results of the research. However, collaboration beyond the boundaries of science can help a research project reach its societal impact goals even if it does not contribute to the epistemic outcomes of the project at all. Instead, other kinds of contributions from the extra-academic partners, and what the extra-academic partners receive from the collaboration, can be crucial. Recognizing this helps us to better understand existing practices, and to identify potentially interesting forms of collaboration beyond the boundaries of science.
The Alaskan Fur-Seal Crisis: Science, Capital, and Multilateralism in the Settlement of International Biodiversity Disputes
Authors: Hickling James
Published: April 2023

The history of the Alaskan fur-seal crisis shows that the development of international environmental law and the peaceful settlement of biodiversity-related disputes can occur over the very long term, through a dynamic, iterative, and cyclical process that involves four key steps: the sorting of competing interests; the sifting of evidence and expert opinion; convergence on shared values; and the articulation of new regulatory regimes that reflect those values. The fur-seal dispute followed this pattern; it occurred over a period of more than 25 years during which the parties initiated several resets of the cycle until finally reaching a durable multilateral agreement grounded in a commitment to the rule of law and the rational use of natural resources. The main obstacles that prevented a more timely and efficient resolution were scientific uncertainty and risk to investment capital. The parties found they could not reach agreement on the causes of the decline of fur-seal populations, but they could agree on a regulatory model that incented the reallocation of private capital away from unsustainable activities, and that provided for an equitable sharing of public revenues in the long term, including through compensatory payments in exchange for restraint in the exercise of legal rights. This manuscript traces the origins of the dispute and the steps taken to reach a solution, including the several joint scientific inquiries commissioned by the parties, and invites discussion about how the lessons of the fur-seal crisis could be applied to avoid and resolve future biodiversity-related disputes.
Writing a Transnational (Global?) History of Extradition Law in the Short Twentieth Century: Beyond Western-Centric Approaches
Authors: del Hierro Pablo , Lixinski Lucas
Published: April 2023

The article examines the history of extradition in the twentieth century, to call for a broader engagement with extradition law not only as an under-explored chapter in international law in its own right, but also as a pathway to think more deeply about world-ruling projects. Extradition law, normally thought of as primarily bilateral, in fact has a long and rich history of multilateral engagement. This tension between multilateralism and bilateralism, we argue, showcases the role of technique to hide political projects in international law-making, as well as showcasing the need to include more non-Eurocentric voices in our narratives about the design of international law instruments and institutions. European nations in the period we survey were more invested in bilateral efforts, claiming the impossibility of multilateral treaty-making in extradition law; yet, Latin American states successfully undertook multiple initiatives in this realm, which are often excluded from mainstream narratives, at the cost of buying into a biased narrative of bilateral treaties that neglects how extradition law has been used to shape and hide key political tensions. In light of these findings, the article puts forth a research agenda that takes extradition more seriously into our accounts of the evolution of international law.
The Speech of the Subaltern Transcribed: Quoting Practices and Language ‘Errors’ in Colonial Travel Writing
Authors: Toivanen Mikko
Published: April 2023

This article analyzes the use of quoted speech in nineteenth-century European travel writing from around the Indian Ocean. A careful analysis of when speech was quoted directly, and how its phonetic characteristics were transcribed into printed form, elucidates the power dynamics embedded in the spoken word in colonial contexts while also opening up new perspectives on the rhetorical strategies of imperialism. Of particular interest here is the notion of erroneous speech: colonial travelogues regularly employed direct quotes to highlight what were construed as ‘mispronunciations’ or ‘grammar mistakes’ by indigenous and/or non-European-coded speakers of the language of the colonizer. Such a framing of differing language habits served to inscribe a cultural hierarchy and power differential into moments of interpersonal encounter. Moreover, in the firmly middle-class genre of travel writing, the speech of working-class Europeans was subjected to similar treatment, pointing to the diversity of different ‘subaltern’ positions within the colonial hierarchy.
Anthologizing Kalīla wa-Dimna: The Incipit of the First Risāla
Authors: Gruendler Beatrice , Khalfallah Khouloud
Published: April 2023

The article is devoted to a lengthy incipit, here in the meaning of a copyist’s addition preceding the main text, which constitutes the longest and most substantial later addition to Kalīla wa-Dimna. The incipit, it is argued, makes Kalīla wa-Dimna usable as an anthology of ethical and practical advice geared to a wide audience. The incipit evinces a scholastic structure, whose parts are analyzed and placed in relation to similar elements within the book’s other prefaces and the introductions and conclusions of chapters, supported with charts and a synoptic edition of representative witnesses out of the twenty-seven manuscripts containing it. These can be identified as a structural group, cutting across other text-based groupings of the textual tradition of Kalīla wa-Dimna so far identified. The shared occurrence of the incipit in manuscripts whose main texts belong to different groups, or are idiosyncratic, suggests that copyists were combining multiple sources to produce their versions. This hypothesis is supported by the high degree of cross-copying in the main texts of the manuscripts bearing the incipit relative to other manuscripts.
“Can’t Touch This”: Early Indian Muslim Responses to the Saudi Conquest of the Hijaz
Authors: Majchrowicz Daniel
Published: April 2023

In late 1924–1925, ʿAbd ul-ʿAzīz us-Saʿūd of Najd invaded and conquered the Hijaz. Guided by their austere Wahhabi convictions, his victorious forces quickly destroyed religious and historical sites and banned myriad “un-Islamic” religious and social practices. These changes had a significant impact on Indian pilgrims to the region, who reacted swiftly and emotionally. Some lauded the reforms and others reviled them, but all spoke with the conviction that they were stakeholders in the region’s future. Most Western scholarship on this event examines its geopolitical complications, but in India the rise of the House of Saud had deep emotional and even existential implications. This article examines early responses to Saudi rule as reflected in Urdu print sources, showing how Indian Muslims responded to it by renegotiating the logistics of pilgrimage, debating restrictions to religious tolerance, and recalibrating their own status and place with the emergent “Muslim World.”