bluuebunny/crossref_metadata_2025 huggingface dataset:
Entrained-Flow Coal Gasification Process Simulation with the Emphasis on Empirical Char Conversion Models Optimization Procedure
Authors: Mularski Jakub , Modliński Norbert
Published: March 2021

Computational fluid dynamics (CFD) modeling of an entrained-flow reactor is demonstrated and compared with experimental data. The study is focused on char conversion modeling and its impact on gasification simulation results. An innovative procedure of optimizing input data to empirical char conversion kinetic-diffusion model is investigated, based on the complex carbon burnout kinetic model for oxidation (CBK/E) and gasification (CBK/G). The kinetics of the CBK/G model is determined using the data from char gasification experiments in a drop tube reactor. CFD simulations are performed for the laboratory-scale entrained-flow reactor at Brigham Young University for the bituminous coal. A substantial impact of applied kinetic parameters on the in-reactor gas composition and char conversion factor was observed. The effect was most considerable for the reduction zone, where gasification reactions dominate, although a non-negligible impact could also be observed in the flame zone. Based on the quantitative assessment of the incorporated optimization procedure, its application allowed to obtain one of the lowest errors of CO, H2, CO2, and H2O axial distribution with respect to the experimental data. The maximum errors for these species were equal to 18.48, 7.95, 10.15, and 20.22%, respectively, whereas the average errors were equal to 4.82, 5.47, 4.72, and 9.58%, respectively.
Bench Tests and CFD Simulations of Liquid–Gas Phase Separation Modeling with Simultaneous Liquid Transport and Mechanical Foam Destruction
Authors: Tomtas Paweł , Skwiot Amadeusz , Sobiecka Elżbieta , Obraniak Andrzej , Ławińska Katarzyna , Olejnik Tomasz P.
Published: March 2021

This paper presents simulation and bench test results for a special type of centrifugal pump that enables the transport of dispersive foaming liquids and simultaneous separation of the liquid phase. During the design phase, CFD (Computer Fluid Dynamics) simulations were performed using Ansys Fluent. The simulations covered changing the operating parameters of the pump (mass/volume flow rate), pressure analysis for the first impeller, and structural optimization of the pump components. In the second stage of the research, the pump and a measuring station were constructed to validate the results of the numerical simulations.
Optimal Siting and Sizing of Distributed Generators by Strawberry Plant Propagation Algorithm
Authors: Shahzad Mohsin , Akram Waseem , Arif Muhammad , Khan Uzair , Ullah Barkat
Published: March 2021

Increasing the unplanned penetration of Distributed Generators (DGs) has spurred active and reactive power losses in the distribution system. This article suggests using a novel Strawberry Plant Propagation Algorithm (SPPA) for planning the placement of the DGs with the aim of reducing the network (active) power losses and improving the overall voltage profile. The proposed method (SPPA) has been tested on 33 and 69 node radial systems in MATLAB. A cost analysis was also performed and compared with other contemporary methods. The results for the considered variables show the significance of the proposed method in comparison to various other counterparts, including the Mine Blast Algorithm and Particle Swarm Optimization.
Conical Two-Phase Swirl Flow Atomizers—Numerical and Experimental Study
Authors: Ochowiak Marek , Janecki Daniel , Krupińska Andżelika , Włodarczak Sylwia , Wilk Tomasz , Olszewski Radosław
Published: March 2021

This paper presents the results of numerical simulations for the developed and discussed conical two-phase atomizers with swirl flow, differing in the ratio of the height of the swirl chamber to its diameter. Experiments were carried out for SAN-1 with HS/DS = 1 and SAN-2 with HS/DS = 4 atomizers. The study was conducted over a range of Reynolds number for liquid ReL = (1400; 5650) and for gas ReG = (2970; 9900). Numerical calculations were performed with the use of computational fluid dynamics (CFD), which were verified on the basis of experimental data. Based on the analysis of experimental studies and simulations results the influence of operational parameters and changes of the atomizer geometry on the generated spray was demonstrated. As the gas flow rate increased and the swirl chamber height decreased, the spray angle increased. Higher velocity values of the liquid and greater turbulence occur in the center of the spray. The flow inside the atomizer determines the nature of the spray obtained. The geometry of the swirl chamber influences the air core formed inside the atomizer, and this determines the atomization effect. The results of numerical simulations not only confirm the results of experimental studies, but also provide additional information on internal and external fluid flow.
A Review of Heat Recovery in Ventilation
Authors: Zender–Świercz Ewa
Published: March 2021

The purpose of the article was to present information on heat recovery in ventilation systems and to highlight what has not been sufficiently researched in this regard. A lot of information can be found on methods and exchangers for heat recovery in centralized systems. Decentralized, façade systems for cyclical supply and exhaust air have not been sufficiently researched. It is known that these devices are sensitive to the influence of wind and temperature, hence heat recovery may be ineffective in their case. The literature describes the aspect of heat recovery depending on the location in climatic zones, depending on the number of degree days (HDD). Attention was also paid to the risk of freezing of heat recovery exchangers. The literature review also showed the lack of a universal method for assessing heat recovery exchangers and the method of their selection depending on the climate.
Developing a Methodology for Aggregated Assessment of the Economic Sustainability of Pig Farms
Authors: Malak-Rawlikowska Agata , Gębska Monika , Hoste Robert , Leeb Christine , Montanari Claudio , Wallace Michael , de Roest Kees
Published: March 2021

The economic sustainability of agricultural production is a crucial concern for most farmers, especially for pig producers who face dynamic changes in the market. Approaches for economic sustainability assessment found in the literature are mainly focused on the short-term economic viability of the farm and rarely take a long-term perspective. In this paper, we propose and test a new, innovative assessment and aggregation method, which brings about a broader view on more long-term aspects of economic sustainability. This wider view on economic sustainability, in addition to classical concepts such as technical efficiency, labor productivity, and farm profitability, incorporates the assessment of the levels of entrepreneurship, risk management, and the resilience of the invested resources. All indicators were scaled and aggregated using scaling and weighting procedures proposed by experts into subthemes and themes. The methodology was tested on a sample of 131 pig farms located in 6 EU countries: Germany, Italy, the Netherlands, Poland, Finland, and Austria. We hypothesized that closed-cycle farms might be economically more sustainable than those farms that are specialized in pig breeding or finishing. The results showed that closed-cycle farms do indeed have advantages in terms of raising healthy animals and having slightly better overall resilience of resources, however specialized breeding and finishing farms appeared to be more sustainable in the areas of profitability, risk management, and reproductive efficiency. Our approach supports evidence-based economic sustainability assessments of pig farms and provides a tool that can be used for economic sustainability improvement strategies for farms.
Multi-Level Multi-Input Converter for Hybrid Renewable Energy Generators
Authors: Foti Salvatore , Testa Antonio , De Caro Salvatore , Tornello Luigi Danilo , Scelba Giacomo , Cacciato Mario
Published: March 2021

A three-phase multi-level multi-input power converter topology is presented for grid-connected applications. It encompasses a three-phase transformer that is operated on the primary side in an open-end winding configuration. Thus, the primary winding is supplied on one side by a three-phase N-level neutral point clamped inverter and, on the other side, by an auxiliary two-level inverter. A key feature of the proposed approach is that the N-level inverter is able to perform independent management of N − 1 input power sources, thus avoiding the need for additional dc/dc power converters in hybrid multi-source systems. Moreover, it can manage an energy storage system connected to the dc-bus of the two-level inverter. The N-level inverter operates at a low switching frequency and can be equipped with very low on-state voltage drop Insulated-Gate Bipolar Transistor (IGBT) devices, while the auxiliary inverter is instead operated at low voltage according to a conventional high-frequency two-level Pulse Width Modulation (PWM) technique and can be equipped with very low on-state resistance Metal-Oxide-Semiconductor Field-Effect Transistor (MOSFET) devices. Simulations and experimental results confirm the effectiveness of the proposed approach and its good performance in terms of grid current harmonic content and overall efficiency.
Environmental Impacts of Conventional versus Organic Eggplant Cultivation Systems: Influence of Electricity Mix, Yield, Over-Fertilization, and Transportation
Authors: Foteinis Spyros , Hatzisymeon Maria , Borthwick Alistair G. L. , Chatzisymeon Efthalia
Published: March 2021

We report a comparative environmental study of organic and conventional open-field eggplant cultivation systems under Mediterranean (northern Greece) climatic conditions. Actual life cycle inventory (LCI) data were collected from local farm systems. Using life cycle assessment (LCA), organic eggplant cultivation exhibited better environmental performance per unit area (24.15% lower total environmental footprint compared to conventional cultivation), but conventional cultivation performed better per unit of mass (28.10% lower total environmental footprint compared to organic cultivation). The conventional system attained higher scores in eutrophication (up to 37.12%) and ecotoxicity (up to 83.00%) midpoint impact categories, due to the use of chemical fertilizer and pesticide. This highlights the need for spatially explicit LCA that accounts for local environmental impacts at the local scale. For both cultivation systems, the main environmental hotspot was groundwater abstraction for irrigation owing to its infrastructure (drip irrigation pipes and pump) and electricity consumption from the fossil fuel-dependent energy mix in Greece. Excessive addition of soil fertilizer greatly affected the environmental sustainability of both systems, especially conventional cultivation, indicating an urgent need for fertilizer guidelines that enhance environmentally sustainable agricultural practice worldwide. Results were sensitive to lower marketable fruit yield, with the organic system performing better in terms of environmental relevance with respect to maximum yield. When renewable energy sources (RES) were used to drive irrigation, both systems exhibited reductions in total environmental footprint, suggesting that RES could help decarbonise the agricultural sector. Finally, eggplant transportation greatly affected the environmental sustainability of both cultivation systems, confirming that local production and consumption are important perquisites for environmental sustainability of agricultural products.
Frequency and Amplitude Modulations of a Moving Structure in Unsteady Non-Homogeneous Density Fluid Flow
Authors: Rajaomazava Tolotra Emerry , Benaouicha Mustapha , Astolfi Jacques-André , Boudraa Abdel-Ouahab
Published: March 2021

A fluid-structure interaction’s effects on the dynamics of a hydrofoil immersed in a fluid flow of non-homogeneous density is presented and analyzed. A linearized model is applied to solve the fluid-structure coupled problem. Fluid density variations along the hydrofoil upper surface, based on the sinusoidal cavity oscillations, are used. It is shown that for the steady cavity case, the value of cavity length Lp does not affect the amplitude of the hydrofoil displacements. However, the natural frequency of the structure increases according to Lp. In the unsteady cavity case, the variations of the added mass and added damping (induced by the fluid density rate of change) generate frequency and amplitude modulations in the hydrofoil dynamics. To analyse this phenomena, the empirical mode decomposition, a well established data-driven method to handle such modulations, is used.
Implicit Type Constitutive Relations for Elastic Solids and Their Use in the Development of Mathematical Models for Viscoelastic Fluids
Authors: Průša Vít , Rajagopal K. R.
Published: March 2021

Viscoelastic fluids are non-Newtonian fluids that exhibit both “viscous” and “elastic” characteristics in virtue of the mechanisms used to store energy and produce entropy. Usually, the energy storage properties of such fluids are modeled using the same concepts as in the classical theory of nonlinear solids. Recently, new models for elastic solids have been successfully developed by appealing to implicit constitutive relations, and these new models offer a different perspective to the old topic of the elastic response of materials. In particular, a sub-class of implicit constitutive relations, namely relations wherein the left Cauchy–Green tensor is expressed as a function of stress, is of interest. We show how to use this new perspective in the development of mathematical models for viscoelastic fluids, and we provide a discussion of the thermodynamic underpinnings of such models. We focus on the use of Gibbs free energy instead of Helmholtz free energy, and using the standard Giesekus/Oldroyd-B models, we show how the alternative approach works in the case of well-known models. The proposed approach is straightforward to generalize to more complex settings wherein the classical approach might be impractical or even inapplicable.
Total Saponins Isolated from Corni Fructus via Ultrasonic Microwave-Assisted Extraction Attenuate Diabetes in Mice
Authors: An Shujing , Niu Dou , Wang Ting , Han Binkai , He Changfen , Yang Xiaolin , Sun Haoqiang , Zhao Ke , Kang Jiefang , Xue Xiaochang
Published: March 2021

Saponins have been extensively used in the food and pharmaceutical industries because of their potent bioactive and pharmacological functions including hypolipidemic, anti-inflammatory, expectorant, antiulcer and androgenic properties. A lot of saponins-containing foods are recommended as nutritional supplements for diabetic patients. As a medicine and food homologous material, Corni Fructus (CF) contains various active ingredients and has the effect of treating diabetes. However, whether and how CF saponins attenuate diabetes is still largely unknown. Here, we isolated total saponins from CF (TSCF) using ultrasonic microwave-assisted extraction combined with response surface methodology. The extract was further purified by a nonpolar copolymer styrene type macroporous resin (HPD-300), with the yield of TSCF elevated to 13.96 mg/g compared to 10.87 mg/g obtained via unassisted extraction. When used to treat high-fat diet and streptozotocin-induced diabetic mice, TSCF significantly improved the glucose and lipid metabolisms of T2DM mice. Additionally, TSCF clearly ameliorated inflammation and oxidative stress as well as pancreas and liver damages in the diabetic mice. Mechanistically, TSCF potently regulated insulin receptor (INSR)-, glucose transporter 4 (GLUT4)-, phosphatidylinositol 3-kinase (PI3K)-, and protein kinase B (PKB/AKT)-associated signaling pathways. Thus, our data collectively demonstrated that TSCF could be a promising functional food ingredient for diabetes improvement.
Load Forecasting in an Office Building with Different Data Structure and Learning Parameters
Authors: Ramos Daniel , Khorram Mahsa , Faria Pedro , Vale Zita
Published: March 2021

Energy efficiency topics have been covered by several energy management approaches in the literature, including participation in demand response programs where the consumers provide load reduction upon request or price signals. In such approaches, it is very important to know in advance the electricity consumption for the future to adequately perform the energy management. In the present paper, a load forecasting service designed for office buildings is implemented. In the building, using several available sensors, different learning parameters and structures are tested for artificial neural networks and the K-nearest neighbor algorithm. Deep focus is given to the individual period errors. In the case study, the forecasting of one week of electricity consumption is tested. It has been concluded that it is impossible to identify a single combination of learning parameters as different parts of the day have different consumption patterns.
Swelling and Drug Release in Polymers through the Theory of Poisson–Kac Stochastic Processes
Authors: Adrover Alessandra , Venditti Claudia , Giona Massimiliano
Published: March 2021

Experiments on swelling and solute transport in polymeric systems clearly indicate that the classical parabolic models fail to predict typical non-Fickian features of sorption kinetics. The formulation of moving-boundary transport models for solvent penetration and drug release in swelling polymeric systems is addressed hereby employing the theory of Poisson–Kac stochastic processes possessing finite propagation velocity. The hyperbolic continuous equations deriving from Poisson–Kac processes are extended to include the description of the temporal evolution of both the Glass–Gel and the Gel–Solvent interfaces. The influence of polymer relaxation time on sorption curves and drug release kinetics is addressed in detail.
Cardiac Contractility Modulation in Patients with Heart Failure with Reduced Left Ventricular Ejection Fraction
Authors: Giallauria Francesco , Parlato Alessandro , Di Lorenzo Anna , Testa Crescenzo , D’Onofrio Antonio , Sinagra Gianfranco , Biffi Mauro , Vigorito Carlo , Coats Andrew J. S.
Published: March 2021

Cardiac contractility modulation is an innovative therapy conceived for the treatment of heart failure. It is a device-based therapy, employing multiple electrodes to deliver relatively high-voltage (~7.5 V) biphasic signals to the endocardium of the right ventricular septum, in order to improve heart failure symptoms, exercise capacity and quality of life. Multiple clinical and mechanistic studies have been conducted to investigate the potential usefulness of this technology and, as of now, they suggest that it could have a place in therapy and meet a relevant medical need for a specific sub-category of underserved heart failure patients with reduced left ventricular ejection fraction. More studies are needed to further investigate its effect on outcomes such as mortality and rate of hospitalizations.
Estimation of Glucosinolates and Anthocyanins in Kale Leaves Grown in a Plant Factory Using Spectral Reflectance
Authors: Chowdhury Milon , Ngo Viet-Duc , Islam Md Nafiul , Ali Mohammod , Islam Sumaiya , Rasool Kamal , Park Sang-Un , Chung Sun-Ok
Published: March 2021

The spectral reflectance technique for the quantification of the functional components was applied in different studies for different crops, but related research on kale leaves is limited. This study was conducted to estimate the glucosinolate and anthocyanin components of kale leaves cultivated in a plant factory based on diffuse reflectance spectroscopy through regression methods. Kale was grown in a plant factory under different treatments. After specific periods of transplantation, leaf samples were collected, and reflectance spectra were measured immediately from nine different points on each leaf. The same leaf samples were freeze-dried and stored for analysis of the functional components. Regression procedures, such as principal component regression (PCR), partial least squares regression (PLSR), and stepwise multiple linear regression (SMLR), were applied to relate the functional components with the spectral data. In the laboratory analysis, progoitrin and glucobrassicin, as well as cyanidin and malvidin, were found to be dominating components in glucosinolates and anthocyanins, respectively. From the overall analysis, the SMLR model showed better performance, and the identified wavelengths for estimating the glucosinolates and anthocyanins were in the early near-infrared (NIR) region. Specifically, reflectance at 742, 761, 787, 796, 805, 833, 855, 932, 947, and 1000 nm showed a strong correlation.
Effect of Root Restriction on the Performance of Three-Truss Cultivated Tomato in the Low-Node Pinching Order at High-Density Cultivation System
Authors: Ayarna Alex Williams , Tsukagoshi Satoru , Oduro Nkansah George
Published: March 2021

The low-node pinching order at a high-density plant cultivation system (LN&HD) is now widely adopted for increasing tomato yield and fruit quality. The LN&HD cultivation period spans 70–120 days, employs the use of a small amount of substrate (low substrate volume), and plants are usually topped between the first and the fourth truss. Using a small amount of substrate in cultivation induces root restriction. Increasing the extent of root restriction in small pots has been adopted for increasing the fruit quality of tomato in some advanced countries. However, improving fruit quality at the expense of yield becomes a major drawback for adopting the LN&HD in Ghana. The LN&HD was introduced into Ghana mainly to increase tomato yield sustainably at a cost-effective level. This study aimed to manipulate or reduce the extent of root restriction to increase tomato yield. Information related to manipulating or reducing the extent of root restriction has not been extensively reported. Thus, an experiment was conducted (between 21 April 2019 and 11 August 2019) in the greenhouse of the University of Ghana Forest and Horticultural Research Centre, Kade-Ghana. Plants of two tomato cultivars (Jaguar and Momotaro York) were subjected to four root restriction conditions. The extent of root restriction were (1) complete root restriction in a 1.0 L volume capacity pot, (2) complete root restriction in a 1.5 L volume capacity pot, (3) partial root restriction in Rockwool-like cultivation, otherwise referred to as Cocowool, and (4) No root restriction in a trough containing 1.5 L of the substrate. The experiment was laid out in a 2 x 4 factorial in a randomized complete block. Results showed that partial root restriction in Cocowool and unrestricted roots in the trough produced the highest tomato yield and total dry matter compared to the plants that received complete root restrictions in the 1.0 and 1.5 L pots. However, the tomato’s total soluble solids increased with a complete root restriction in the 1.0 L pot. Reducing the extent of root restriction increased the yield and total dry matter of tomato. With the LN&HD, a small amount of substrate could be used (at a reduced cost) with a partial root restriction to increase the yield of tropical tomato cultivars grown in Ghana.
COVID-19 and Health-Related Quality of Life: A Community-Based Online Survey in Hong Kong
Authors: Choi Edmond Pui Hang , Hui Bryant Pui Hung , Wan Eric Yuk Fai , Kwok Jojo Yan Yan , Tam Tiffany Hei Lam , Wu Chanchan
Published: March 2021

The COVID-19 pandemic itself and related public health measurements have had substantial impacts on individual social lives and psychological and mental health, all to the detriment of health-related quality of life (HRQoL). There have been extensive studies investigating the mental health of people in different populations during the COVID-19 pandemic. However, few studies have explored the impact of COVID-19 and its association with HRQoL. To fill this research gap and provide further empirical evidence, this study examined the impact of COVID-19 on Hong Kong people and evaluated its association with HRQoL. A total of 500 participants were randomly recruited to complete an online questionnaire on their concerns related to COVID-19. This entailed responding to the World Health Organization Quality of Life-BREF instrument. Data were collected between 24 April and 3 May 2020. Independent t-tests and multiple linear regressions were used to examine the association between the impact of COVID-19 and HRQoL. Overall, 69.6% of participants were worried about contracting COVID-19, and 41.4% frequently suspected themselves of being infected. Furthermore, 29.0% were concerned by the lack of disinfectants. All of these findings were associated with poorer HRQoL in the physical and psychological health, social relationships, and environment domains. On the other hand, 47.4% of participants were concerned that they may lose their job because of the pandemic, while 39.4% were bothered by the insufficient supply of surgical masks. These two factors were associated with poorer HRQoL in the physical and psychological health and environment domains. The adverse impact of COVID-19 on individuals is multifactorial, affecting all aspects of HRQoL. In addition to enhancing anti-epidemic efforts, it is equally important to implement public health and social welfare measures, thereby diminishing the adverse impact of COVID-19 on overall well-being.
Prolonged Post-Exercise Hypotension: Effects of Different Exercise Modalities and Training Statuses in Elderly Patients with Hypertension
Authors: Iellamo Ferdinando , Caminiti Giuseppe , Montano Matteo , Manzi Vincenzo , Franchini Alessio , Mancuso Annalisa , Volterrani Maurizio
Published: March 2021

Background: In this study, we aimed at comparing the effects of three different exercise modalities on post-exercise hypotension (PEH) in elderly hypertensive patients and at investigating whether PEH responses to the same exercises are affected by their training status. Methods: Thirty-six male sedentary hypertensive patients over 60 years old, were included. They were divided into three groups each one corresponding to a different exercise modality, i.e., aerobic continuous exercise (ACE), high-intensive interval exercise (HIIE), and combined (aerobic and resistance) exercise (CE). PEH was assessed in each group by ambulatory blood pressure monitoring (ABPM) in two different conditions as follows: (1) sedentary status and (2) trained status, at the end of a 12 week of ACE training program. A cardiopulmonary test was performed before and at the end of the training program. Results: In the sedentary status, 24-h and nocturnal systolic and diastolic blood pressure (BP) decreased in all groups as compared with top pre-exercise, with a greater but not significant reduction in the ACE and CE groups as compared with HIIE. ACE and HIIE groups presented a more sustained PEH than CE. In the trained status, 24-h and nighttime systolic and diastolic BP decreased significantly only after HIIE, but were unchanged as compared with pre-exercise in the ACE and CE groups. Conclusions: ACE and CE produced greater PEH than HIIE in sedentary elderly hypertensive patients. However, after training, HIIE produced the greater and more sustained PEH. The training status appears to exert significant effects on PEH produced by different exercise modalities.
Depression and Anxiety in Patients with Rare Diseases during the COVID-19 Pandemic
Authors: Sánchez-García Juan Carlos , Cortés-Martín Jonathan , Rodríguez-Blanque Raquel , Marín-Jiménez Ana Eugenia , Montiel-Troya Maria , Díaz-Rodríguez Lourdes
Published: March 2021

Scientific knowledge on depression and anxiety in patients with rare diseases during the COVID-19 pandemic is scarce; however, it is essential to perform comprehensive management of these patients. The aim of this study was to research how the situation caused by the SARS-CoV-2 pandemic has influenced the lives of patients with rare diseases regarding depression and anxiety. This Spanish study considered a heterogeneous population sample of 86 patients with confirmed diagnosis of different rare diseases. Participants took part in a cross-sectional online study by completing specific questionnaires on the study topic. Depression was measured using the Patient Health Questionnaire (PHQ-9), and the General Anxiety Disorder Scale (GAD-7) was used for evaluating anxiety. Data collection through an online questionnaire allowed for a greater population scope and therefore the inclusion patients of other nationalities in the study sample. Finally, as a general result, this study found that, in the face of the pandemic, anxiety and depression remained at a higher level in this group than in the general population, making these patients a vulnerable population group.
Fear of COVID-19 for Individuals and Family Members: Indications from the National Cross-Sectional Study of the EPICOVID19 Web-Based Survey
Authors: Cori Liliana , Curzio Olivia , Adorni Fulvio , Prinelli Federica , Noale Marianna , Trevisan Caterina , Fortunato Loredana , Giacomelli Andrea , Bianchi Fabrizio
Published: March 2021

The study analyzed the association of the fear of contagion for oneself and for family members (FMs) during the first wave of the COVID-19 pandemic, with demographic and socioeconomic status (SES) and health factors. The study was performed within the EPICOVID19 web-based Italian survey, involving adults from April–June 2020. Out of 207,341 respondents, 95.9% completed the questionnaire (60% women with an average age of 47.3 vs. 48.9 years among men). The association between fear and demographic and SES characteristics, contacts with COVID-19 cases, nasopharyngeal swab, self-perceived health, flu vaccination, chronic diseases and specific symptoms was analyzed by logistic regression model; odds ratios adjusted for sex, age, education and occupation were calculated (aORs). Fear for FMs prevailed over fear for oneself and was higher among women than men. Fear for oneself decreased with higher levels of education and in those who perceived good health. Among those vaccinated for the flu, 40.8% responded they had feelings of fear for themselves vs. 34.2% of the not vaccinated. Fear increased when diseases were declared and it was higher when associated with symptoms such as chest pain, olfactory/taste disorders, heart palpitations (aORs > 1.5), lung or kidney diseases, hypertension, depression and/or anxiety. Trends in fear by region showed the highest percentage of positive responses in the southern regions. The knowledge gained from these results should be used to produce tailored messages and shared public health decisions.
Match Day-1 Reactive Strength Index and In-Game Peak Speed in Collegiate Division I Basketball
Authors: Petway Adam J. , Freitas Tomás T. , Calleja-González Julio , Alcaraz Pedro E.
Published: March 2021

Basketball is a game of repeated jumps and sprints. The objective of this study was to examine whether repeated jump assessments the day prior to competition (MD-1) could discriminate between fast and slow in-game performances the following day. Seven NCAA Division I Basketball athletes (4 guards and 3 forwards; 20 ± 1.2 years, 1.95 ± 0.09 m, and 94 ± 15 kg) performed a repeated-hop test on a force platform before and after each practice MD-1 to assess Reactive Strength Index (RSI) and Jump Height (JH). Peak speed was recorded during games via spatial tracking cameras. A median split analysis classified performance into FAST and SLOW relative to individual in-game peak speed. Paired T-tests were performed to assess post- to pre-practices differences. An independent sample T-test was used to assess the differences between FAST and SLOW performances. Cohen’s d effect sizes (ES) were calculated to determine the magnitude of the differences. Statistical significance was set for p ≤ 0.05. Post-practice RSI and JH were significantly higher than pre-training values prior to the FAST but not the SLOW in-game performances. A significant difference was found for MD-1 RSI when comparing FAST and SLOW conditions (p = 0.01; ES = 0.62). No significant between-group differences were obtained in JH (p = 0.07; ES = 0.45). These findings could have implications on the facilitation of reactive strength qualities in conjunction with match-play. Practitioners should evaluate the placement of stimuli to potentiate athlete readiness for competition.
Development and Effectiveness of a Patient Safety Education Program for Inpatients
Authors: Shin Sun Hwa , Kim Mi Jung , Moon Ho Jin , Lee Eun Hye
Published: March 2021

Background: Patient safety is considered an important issue in the field of healthcare, and most advanced countries. Purpose: This study was designed to evaluate a patient safety education program among hospitalized patients. Of the 69 participants, 33 completed the patient safety education program while the 36 remaining participants were given educational booklets. The program was used to measure knowledge about patient safety, patient safety perception, and willingness to participate in patient safety. Methods: Patient safety education was developed by the analysis–design–development–implementation–evaluation model considering expert advice, patient needs, and an extensive literature review. Data were collected from 20 July to 13 November 2020. Data were analyzed using SPSS statistical program. The effectiveness of the experimental and control groups before and after education was analyzed using paired t-tests, and the difference in the amount of increase in the measured variables for each group was analyzed using independent t-tests. Results: The experimental group had significantly higher patient safety scores (t = 2.52, p = 0.014) and patient safety perception (t = 2.09, p = 0.040) than those of the control group. However, there was no significant difference between the two groups regarding the willingness to participate in patient safety. Conclusion: The patient safety education program developed using mobile tablet PCs could be an effective tool to enhance patient involvement in preventing events that may threaten the safety of patients. Further studies are recommended to develop a variety of educational interventions to increase patient safety knowledge and perceptions of patients and caregivers.
Measuring Time-Varying Effective Reproduction Numbers for COVID-19 and Their Relationship with Movement Control Order in Malaysia
Authors: Musa Kamarul Imran , Arifin Wan Nor , Mohd Mohd Hafiz , Jamiluddin Mohammad Subhi , Ahmad Noor Atinah , Chen Xin Wee , Hanis Tengku Muhammad , Bulgiba Awang
Published: March 2021

To curb the spread of SARS-CoV-2 virus (COVID-19) in Malaysia, the government imposed a nationwide movement control order (MCO) from 18 March 2020 to 3 May 2020. It was enforced in four phases (i.e., MCO 1, MCO 2, MCO 3 and MCO 4). In this paper, we propose an initiative to assess the impact of MCO by using time-varying reproduction number (Rt). We used data from the Johns Hopkins University Centre for Systems Science and Engineering Coronavirus repository. Day 1 was taken from the first assumed local transmission of COVID-19. We estimated Rt by using the EpiEstim package and plotted the epidemic curve and Rt. Then, we extracted the mean Rt at day 1, day 5 and day 10 for all MCO phases and compared the differences. The Rt values peaked around day 43, which was shortly before the start of MCO 1. The means for Rt at day 1, day 5, and day 10 for all MCOs ranged between 0.665 and 1.147. The average Rt gradually decreased in MCO 1 and MCO 2. Although spikes in the number of confirmed cases were observed when restrictions were gradually relaxed in the later MCO phases, the situation remained under control with Rt values being stabilised to below unity level (Rt value less than one).
The Impact of Fluid Loss and Carbohydrate Consumption during Exercise, on Young Cyclists’ Fatigue Perception in Relation to Training Load Level
Authors: Cesanelli Leonardo , Ylaitė Berta , Messina Giuseppe , Zangla Daniele , Cataldi Stefania , Palma Antonio , Iovane Angelo
Published: March 2021

High-level young athletes need to face a wide spectrum of stressors on their journey to élite categories. The aims of the present study are (i) to evaluate session rate of perceived exertion (sRPE) at different training impulse (TRIMP) categories and the correlations between these two variables and, (ii) evaluate the correlations between sRPE, fluid loss, and carbohydrate consumption during exercise. Data on Edward’s TRIMP, sRPE, body mass loss pre- and post- exercise (∆), and carbohydrate consumption (CHO/h) during exercise have been acquired from eight male junior cyclists during a competitive season. One-way ANOVA and correlation analysis with linear regression have been performed on acquired data. sRPE resulted in a significant difference in the three TRIMP categories (p < 0.001). sRPE resulted in being very largely positively associated with TRIMP values (p < 0.001; R = 0.71). ∆ as well as CHO/h was largely negatively related with sRPE in all TRIMP categories (p < 0.001). The results confirmed the role of fluid balance and carbohydrate consumption on the perception of fatigue and fatigue accumulation dynamics independently from the training load. Young athletes’ training load monitoring and nutritional-hydration support represent important aspects in athlete’s exercise-induced fatigue management.
An Overview of Thermal Infrared Imaging-Based Screenings during Pandemic Emergencies
Authors: Perpetuini David , Filippini Chiara , Cardone Daniela , Merla Arcangelo
Published: March 2021

Infrared thermal imaging (IRI) is a contact-less technology able to monitor human skin temperature for biomedical applications and in real-life contexts. Its capacity to detect fever was exploited for mass screening during past epidemic emergencies as well as for the current COVID-19 pandemic. However, the only assessment of fever may not be selective for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Hence, novel approaches for IRI data analysis have been investigated. The present review aims to describe how IRI have been employed during the last epidemics, highlighting the potentialities and the limitations of this technology to contain the contagions. Specifically, the methods employed for automatic face recognition and fever assessment and IRI’s performances in mass screening at airports and hospitals are reviewed. Moreover, an overview of novel machine learning methods for IRI data analysis, aimed to identify respiratory diseases, is provided. In addition, IRI-based smart technologies developed to support the healthcare during the COVID-19 pandemic are described. Finally, relevant guidelines to fully exploit IRI for COVID-19 identification are defined, to improve the effectiveness of IRI in the detection of the SARS-CoV-2 infection.
Evaluation of Patient No-Shows in a Tertiary Hospital: Focusing on Modes of Appointment-Making and Type of Appointment
Authors: Suk Mi Young , Kim Bomgyeol , Lee Sang Gyu , You Chang Hoon , Hyun Kim Tae
Published: March 2021

No-show appointments waste resources and decrease the sustainability of care. This study is an attempt to evaluate patient no-shows based on modes of appointment-making and types of appointments. We collected hospital information system data and appointment data including characteristics of patients, service providers, and clinical visits over a three-month period (1 September 2018 to 30 November 2018), at a large tertiary hospital in Seoul, Korea. We used multivariate logistic regression analyses to identify the factors associated with no-shows (Model 1). We further assessed no-shows by including the interaction term (“modes of appointment-making” X “type of appointment”) (Model 2). Among 1,252,127 appointments, the no-show rate was 6.12%. Among the modes of appointment-making, follow-up and online/telephone appointment were associated with higher odds of no-show compared to walk-in. Appointments for treatment and surgery had higher odds ratios of no-show compared to consultations. Tests for the interaction between the modes of appointment-making and type of appointment showed that follow-up for examination and online/telephone appointments for treatment and surgery had much higher odds ratios of no-shows. Other significant factors of no-shows include age, type of insurance, time of visit, lead time (time between scheduling and the appointment), type of visits, doctor’s position, and major diagnosis. Our results suggest that future approaches for predicting and addressing no-show should also consider and analyze the impact of modes of appointment-making and type of appointment on the model of prediction.
CaMKIIα Expressing Neurons to Report Activity-Related Endogenous Hypoxia upon Motor-Cognitive Challenge
Authors: Butt Umer Javed , Hassouna Imam , Fernandez Garcia-Agudo Laura , Steixner-Kumar Agnes A. , Depp Constanze , Barnkothe Nadine , Zillmann Matthias R. , Ronnenberg Anja , Bonet Viktoria , Goebbels Sandra , Nave Klaus-Armin , Ehrenreich Hannelore
Published: March 2021

We previously introduced the brain erythropoietin (EPO) circle as a model to explain the adaptive ‘brain hardware upgrade’ and enhanced performance. In this fundamental circle, brain cells, challenged by motor-cognitive tasks, experience functional hypoxia, triggering the expression of EPO among other genes. We attested hypoxic cells by a transgenic reporter approach under the ubiquitous CAG promoter, with Hif-1α oxygen-dependent degradation-domain (ODD) fused to CreERT2-recombinase. To specifically focus on the functional hypoxia of excitatory pyramidal neurons, here, we generated CaMKIIα-CreERT2-ODD::R26R-tdTomato mice. Behavioral challenges, light-sheet microscopy, immunohistochemistry, single-cell mRNA-seq, and neuronal cultures under normoxia or hypoxia served to portray these mice. Upon complex running wheel performance as the motor-cognitive task, a distinct increase in functional hypoxic neurons was assessed immunohistochemically and confirmed three-dimensionally. In contrast, fear conditioning as hippocampal stimulus was likely too short-lived to provoke neuronal hypoxia. Transcriptome data of hippocampus under normoxia versus inspiratory hypoxia revealed increases in CA1 CaMKIIα-neurons with an immature signature, characterized by the expression of Dcx, Tbr1, CaMKIIα, Tle4, and Zbtb20, and consistent with accelerated differentiation. The hypoxia reporter response was reproduced in vitro upon neuronal maturation. To conclude, task-associated activity triggers neuronal functional hypoxia as a local and brain-wide reaction mediating adaptive neuroplasticity. Hypoxia-induced genes such as EPO drive neuronal differentiation, brain maturation, and improved performance.
Functional Expression of TRPV1 Ion Channel in the Canine Peripheral Blood Mononuclear Cells
Authors: Bujak Joanna K. , Kosmala Daria , Majchrzak-Kuligowska Kinga , Bednarczyk Piotr
Published: March 2021

TRPV1, known as a capsaicin receptor, is the best-described transient receptor potential (TRP) ion channel. Recently, it was shown to be expressed by non-excitable cells such as lymphocytes. However, the data regarding the functional expression of the TRPV1 channel in the immune cells are often contradictory. In the present study, we performed a phylogenetical analysis of the canine TRP ion channels, we assessed the expression of TRPV1 in the canine peripheral blood mononuclear cells (PBMC) by qPCR and Western blot, and we determined the functionality of TRPV1 by whole-cell patch-clamp recordings and calcium assay. We found high expression of TRPV2, -M2, and -M7 in the canine PBMCs, while expression of TRPV1, -V4 and, -M5 was relatively low. We confirmed that TRPV1 is expressed on the protein level in the PBMC and it localizes in the plasma membrane. The whole-cell patch-clamp recording revealed that capsaicin application caused a significant increase in the current density. Similarly, the results from the calcium assay show a dose-dependent increase in intracellular calcium level in the presence of capsaicin that was partially abolished by capsazepine. Our study confirms the expression of TRPV1 ion channel on both mRNA and protein levels in the canine PBMC and indicates that the ion channel is functional.
Exploring the Genetic Conception of Obesity via the Dual Role of FoxO
Authors: Behl Tapan , Kaur Ishnoor , Sehgal Aayush , Singh Sukhbir , Zengin Gokhan , Negrut Nicoleta , Nistor-Cseppento Delia Carmen , Pavel Flavia Maria , Corb Aron Raluca Anca , Bungau Simona
Published: March 2021

Obesity or overweight are not superficial problems, constituting a pressing issue. The obesity index has almost tripled since 1975, which is an alarming state. Most of the individuals are currently becoming overweight or have inappropriate body mass index (BMI) conditions. Obesity is characterized by increased fat accumulation and thus poses a higher health risk. There is increased size and volume of fat cells in the body, which usually accounts for obesity. Many investigations have been carried out in this area, such as behavioral improvements, dietary changes, chemical involvements, etc., but presently no such goals are established to manage these health concerns. Based on previous literature reports and our interpretation, the current review indicates the involvement of various transcriptional and transporter functions in modifying the above-mentioned health conditions. Various transcriptional factors such as Forkhead box O1 (FoxO1) impart a significant effect on the physiology and pathology of metabolic dysfunction such as obesity. FoxO1 plays a dual role whether in the progression or suppression of metabolic processes depending on its targets. Thus, in the current study, will be discussed the dual role of FoxO1 in metabolic conditions (such as obesity), also summarizing the role of various other transcriptional factors involved in obesity.
Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives
Authors: Đukanović Nina , Obradović Slobodan , Zdravković Marija , Đurašević Siniša , Stojković Maja , Tosti Tomislav , Jasnić Nebojša , Đorđević Jelena , Todorović Zoran
Published: March 2021

Lipids play an essential role in platelet functions. It is known that polyunsaturated fatty acids play a role in increasing platelet reactivity and that the prothrombotic phenotype plays a crucial role in the occurrence of major adverse cardiovascular events. The ongoing increase in cardiovascular diseases’ incidence emphasizes the importance of research linking lipids and platelet function. In particular, the rebound phenomenon that accompanies discontinuation of clopidogrel in patients receiving dual antiplatelet therapy has been associated with changes in the lipid profile. Our many years of research underline the importance of reduced HDL values for the risk of such a rebound effect and the occurrence of thromboembolic events. Lipids are otherwise a heterogeneous group of molecules, and their signaling molecules are not deposited but formed “on-demand” in the cell. On the other hand, exosomes transmit lipid signals between cells, and the profile of such changes can be monitored by lipidomics. Changes in the lipid profile are organ-specific and may indicate new drug action targets.