bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of radiation-induced sterility, longevity, and reproductive characteristics of the Aedes aegypti (Diptera: Culicidae) strain of Swat: A step towards the implementation of SIT in Pakistan
Authors: Khan Inamullah , Khan Gul Zamin , Khan Jehangir , Amin Muhammad
Published: May 2024

Background & objectives:

Biological approaches for vector mosquito control such as sterile insect technique (SIT) requires sterilization of male mosquitoes through specific radiation doses for sterility induction in males. Under the SIT program, the males used must be compatible with the wild males in vigor, flight and selection of mate. Much of this potential is determined by the diet provided in the larval stages and optimizing the irradiation doses that cause complete sterility but have very minimal effect on the lives of irradiated males. The current study is designed to evaluate gamma radiation doses for inducing sterility in male Aedes aegypti mosquitoes with a genomic background from Pakistan (Swat district) and to assess the effects of radiation exposure on the competency of irradiated males and other life traits of irradiated mosquitoes.

Methods:

Sterilization of 17-hour-old male pupae (groups of 50 pupa/cup in three replicates) of the Ae. aegypti Swat strain was conducted using radiation doses of 30, 60, 70, 90, and 105 gray (Gy) from (Co60) at the Nuclear Institute for Food and Agriculture (NIFA) in Peshawar, Pakistan. Post-irradiated pupae were released in adult cages. Virgin females of the same cohort were released (1:1) to mate with the irradiated males. Mortality, longevity, mating competitiveness of males, and female fecundity were recorded.

Results:

An average of 71 eggs per female was recorded in control with 86% hatch rate. Individual females mated with a 60 Gy treated males produced 60 ± 0.6 eggs per female with 17% hatch rate, and those mated with 70 Gy males produced 42 ± 0.01 eggs with a nil hatch rate, whereas females mated with males treated with ≥70 Gy doses did not reproduce to next generation. Females in groups of 50 mated with 60, 70 Gy treated males (equal pairs), produced 369±1.3 and 98±0.01 eggs with 15% and zero hatch rate. Significant dose dependent reduction in longevity was observed for >30 Gy doses. The matting competence of irradiated males was about half that of un-irradiated males.

Interpretation & conclusion:

Aedes aegypti with a Pakistani genomic background treated with a ≥70 Gy dose of gamma radiation induced complete sterility in males and provided the first-step foundation for SIT application in Pakistan. Further extensive studies are required to optimize the SIT techniques so that fully sterile males with very minor quality changes can be produced on large scales for field trials.
Computational design, docking, and molecular dynamics simulation study of RNA helicase inhibitors of dengue virus
Authors: Satpathy Raghunath , Acharya Sonali , Behera Rashmiranjan
Published: May 2024

Background & objectives:

RNA viruses are complex pathogens in terms of their genetic makeup, mutation frequency, and transmission modes. They contain the RNA helicase enzyme, which plays a crucial role in the viral genome replication process. This work aims to develop and screen a potential molecule that could function as a dengue virus (DENV) RNA helicase inhibitor.

Methods:

The present study was performed by taking 26 potential derivatives of gedunin phytochemicals from the PubChem database as ligands. The binding of the compounds was analyzed by in silico docking considering DENV RNA helicase enzyme as the receptor.

Results:

After a thorough analysis of the docking scores, toxicity, and physicochemical properties, the compound tetrahydrogedunin was obtained as the best. Based on tetrahydrogedunin molecular structure, 100 drug-like molecules were designed using the Data Warrior tool. After screening for drug-likeness and ADMET properties, derivative number 42 was considered as promising. Further comparative docking of derivative 42 and a standard inhibitor molecule ST-610 with DENV RNA helicase enzyme showed binding affinity of 10.0 kcal/mol and -9.6 kcal/mol, respectively. The favorable interaction between DENV RNA helicase and derivative 42 was further validated by 50 nanoseconds molecular dynamics simulation and MM-GBSA analysis.

Interpretation & conclusion:

Since the antiviral activity of derivative 42 has not been reported till date, the compound was predicted as a novel therapeutic molecule that can act against the dengue virus (DENV) RNA helicase enzyme.
Research Atlas Analysis on the Application of Huoxue Lishui Method (Promoting Blood Circulation and Diuresis) in Ophthalmology Based on VOSviewer’s and CiteSpace’s Methods
Authors: Luo Qian , Li Ze-Qi , Zhang Xiao-Huan , Yang Yi-Jing , Lu Jing , Peng Qing-Hua
Published: May 2024

Objective:

The objective of this study was to summarize the research context, hotspots, and the development trend of Huoxue lishui method in ophthalmology in the past decade by reviewing the relevant publications.

Materials and Methods:

Relevant publications on the application of Huoxue lishui method in ophthalmology from January 1, 2011, to December 31, 2021, in databases such as CNKI, VIP, and Wanfang were retrieved. The analysis of coauthorship, keyword co-occurrence, keyword clustering, keyword emergence, and keyword timeline map of the publications was done with bibliometrics tools CiteSpace and VOSviewer.

Results:

A total of 100 publications were included in the analysis. The year 2020 saw the publication of most papers concerning the application of Huoxue lishui method in ophthalmology. High-frequency words are macular edema, Huoxue lishui, diabetic macular edema, Huoxue lishui method, Huoxue lishui formula, and promoting Qi and nourishing Yin. Three research hotspots were identified through keyword clustering analysis. Keyword emergence analysis and keyword timeline map indicated that a combined treatment of Huoxue lishui method and promoting Qi and nourishing Yin and diabetic ophthalmology is predicted to be research frontiers.

Conclusions:

Through the use of knowledge maps, this article reveals the research status in this field in the past decade and highlights the major directions, research hotspots, and development trends, providing references for further research in this field.
Об одном свойстве квазикелеровых многообразий
Authors: Banaru Galina Anatol'evna , Banaru Mikhail Borisovich
Published: May 2024

Доказано, что квазикелерово многообразие, удовлетворяющее аксиоме $\eta$-квазиомбилических квазисасакиевых гиперповерхностей, является келеровым многообразием.
Также установлено, что квазисасакиева структура на ориентируемой $\eta$-квазиомбилической гиперповерхности квазикелерова многообразия является либо косимплектической структурой, либо структурой, гомотетичной сасакиевой.
Библиография: 14 названий.
Об одном типе колебательных решений неавтономной системы с релейным гистерезисом
Authors: Yevstafyeva Victoria Viktorovna
Published: May 2024

Рассматривается $n$-мерная система обыкновенных дифференциальных уравнений
первого порядка с постоянной матрицей, имеющей вещественные простые ненулевые собственные числа, c разрывной нелинейностью типа двухпозиционного реле с положительным гистерезисом и
непрерывной ограниченной функцией возмущения.
Изучаются непрерывные двухточечно-колебательные решения
с определенным периодом возврата изображающей точки на гиперплоскость переключения в фазовом пространстве. При решении задачи Коши с начальным условием в точке переключения
используется метод припасовывания.
Построена система трансцендентных уравнений относительно моментов и точек переключения.
Доказан критерий существования и единственности решения с некоторым фиксированным периодом возврата. Для системы в канонической форме с диагональной матрицей и
вектором обратной связи специального вида
получены условия разрешимости системы трансцендентных уравнений
относительно момента первого переключения при заданном
периоде возврата и формулы для точек переключения.
Для трехмерной системы приведен численный пример, иллюстрирующий теоретические результаты.
Библиография: 21 название.
Magnetic resonance imaging-based lymph node radiomics for predicting the metastasis of evaluable lymph nodes in rectal cancer
Authors: Ye Yong-Xia , Yang Liu , Kang Zheng , Wang Mei-Qin , Xie Xiao-Dong , Lou Ke-Xin , Bao Jun , Du Mei , Li Zhe-Xuan
Published: May 2024

BACKGROUND

Lymph node (LN) staging in rectal cancer (RC) affects treatment decisions and patient prognosis. For radiologists, the traditional preoperative assessment of LN metastasis (LNM) using magnetic resonance imaging (MRI) poses a challenge.

AIM

To explore the value of a nomogram model that combines Conventional MRI and radiomics features from the LNs of RC in assessing the preoperative metastasis of evaluable LNs.

METHODS

In this retrospective study, 270 LNs (158 nonmetastatic, 112 metastatic) were randomly split into training (n = 189) and validation sets (n = 81). LNs were classified based on pathology-MRI matching. Conventional MRI features [size, shape, margin, T2-weighted imaging (T2WI) appearance, and CE-T1-weighted imaging (T1WI) enhancement] were evaluated. Three radiomics models used 3D features from T1WI and T2WI images. Additionally, a nomogram model combining conventional MRI and radiomics features was developed. The model used univariate analysis and multivariable logistic regression. Evaluation employed the receiver operating characteristic curve, with DeLong test for comparing diagnostic performance. Nomogram performance was assessed using calibration and decision curve analysis.

RESULTS

The nomogram model outperformed conventional MRI and single radiomics models in evaluating LNM. In the training set, the nomogram model achieved an area under the curve (AUC) of 0.92, which was significantly higher than the AUCs of 0.82 (P < 0.001) and 0.89 (P < 0.001) of the conventional MRI and radiomics models, respectively. In the validation set, the nomogram model achieved an AUC of 0.91, significantly surpassing 0.80 (P < 0.001) and 0.86 (P < 0.001), respectively.

CONCLUSION

The nomogram model showed the best performance in predicting metastasis of evaluable LNs.
To explore the mechanism of Yigong San anti-gastric cancer and immune regulation
Authors: Lu Dou-Dou , Yuan Ling , Wang Zhao-Zhao , Zhao Jian-Jun , Du Yu-Hua , Ning Na , Chen Guo-Qing , Huang Shi-Cong , Yang Yi , Zhang Zhe , Nan Yi
Published: May 2024

BACKGROUND

Yigong San (YGS) is a representative prescription for the treatment of digestive disorders, which has been used in clinic for more than 1000 years. However, the mechanism of its anti-gastric cancer and regulate immunity are still remains unclear.

AIM

To explore the mechanism of YGS anti-gastric cancer and immune regulation.

METHODS

Firstly, collect the active ingredients and targets of YGS, and the differentially expressed genes of gastric cancer. Secondly, constructed a protein-protein interaction network between the targets of drugs and diseases, and screened hub genes. Then the clinical relevance, mutation and repair, tumor microenvironment and drug sensitivity of the hub gene were analyzed. Finally, molecular docking was used to verify the binding ability of YGS active ingredient and hub genes.

RESULTS

Firstly, obtained 55 common targets of gastric cancer and YGS. The Kyoto Encyclopedia of Genes and Genomes screened the microtubule-associated protein kinase signaling axis as the key pathway and IL6, EGFR, MMP2, MMP9 and TGFB1 as the hub genes. The 5 hub genes were involved in gastric carcinogenesis, staging, typing and prognosis, and their mutations promote gastric cancer progression. Finally, molecular docking results confirmed that the components of YGS can effectively bind to therapeutic targets.

CONCLUSION

YGS has the effect of anti-gastric cancer and immune regulation.
Systematic review of risk factors, prognosis, and management of colorectal signet-ring cell carcinoma
Authors: Nuytens Frederiek , Drubay Vincent , Eveno Clarisse , Renaud Florence , Piessen Guillaume
Published: May 2024

BACKGROUND

Colorectal signet-ring cell carcinoma (CSRCC) is a rare clinical entity which accounts for approximately 1% of all colorectal cancers. Although multiple studies concerning this specific topic have been published in the past decades, the pathogenesis, associated risk factors, and potential implications on treatment are still poorly understood. Besides the low incidence, historically confusing histological criteria have resulted in confusing data. Nevertheless, the rising incidence of CSRCC along with relatively young age at presentation and associated dismal prognosis, highlight the actual interest to synthesize the known literature regarding CSRCC.

AIM

To provide an updated overview of risk factors, prognosis, and management of CSRCC.

METHODS

A literature search in the MEDLINE/PubMed database was conducted with the following search terms used: ‘Signet ring cell carcinoma’ and ‘colorectal’. Studies in English language, published after January 1980, were included. Studies included in the qualitative synthesis were evaluated for content concerning epidemiology, risk factors, and clinical, diagnostic, histological, and molecular features, as well as metastatic pattern and therapeutic management. If possible, presented data was extracted in order to present a more detailed overview of the literature.

RESULTS

In total, 67 articles were included for qualitative analysis, of which 54 were eligible for detailed data extraction. CSRCC has a reported incidence between 0.1%-2.4% and frequently presents with advanced disease stage at the time of diagnosis. CSRCC is associated with an impaired overall survival (5-year OS: 0%-46%) and a worse stage-corrected outcome compared to mucinous and not otherwise specified adenocarcinoma. The systematic use of exploratory laparoscopy to determine the presence of peritoneal metastases has been advised. Surgery is the mainstay of treatment, although the rates of curative resection in CSRCC (21%-82%) are lower compared to those in other histological types. In case of peritoneal metastasis, cytoreductive surgery with hyperthermic intraperitoneal chemotherapy should only be proposed in selected patients.

CONCLUSION

CSRCC is a rare clinical entity most often characterized by young age and advanced disease at presentation. As such, diagnostic modalities and therapeutic approach should be tailored accordingly.
Vertigo (1958)
Authors: Uher Valerie
Published: May 2024

Vertigo is a psychological thriller directed and produced by Alfred Hitchcock, based on D’entre les morts [The Living and the Dead], a 1954 crime novel by Boileau-Narcejac. The film is known for its innovative use of cinematography, nuanced depiction of romantic obsession and the presence of numerous Freudian themes, most notably scopophilia and the uncanny. Set in San Francisco, acrophobic ex-detective John ‘Scottie’ Ferguson (James Stewart) is asked by former colleague Gavin Elster (Tom Helmore) to investigate his mentally unstable wife, Madeleine (Kim Novak). The two become romantically involved, as Scottie attempts to decipher Madeleine’s psychosis and amnesia. After what appears to be Madeleine’s suicide, Scottie obsessively follows another woman, Judy Barton (also played by Novak), who bears a striking resemblance to Madeleine. The film concludes with the revelation that Madeleine’s suicide was a ruse for Elster to kill his real wife, whom Judy was impersonating. In keeping with the modernist fascination with the emotional impact of colour and light, contrasts in brightness are used to communicate the characters’ varying degrees of confusion. To emphasize the tenuous distinction between reality and fantasy portrayed in the film, the ‘Dolly zoom,’ or ‘Vertigo Effect’ is used, creating a Surrealistic perspective change through alterations in camera movement and focus. In the 2012 Sight and Sound critic’s poll, Vertigo replaced Citizen Kane as the best film of all time.
City films
Authors: Suárez Juan A.
Published: May 2024

This entry surveys the history and aesthetics of the city symphony film (or city film). It traces its intellectual and aesthetic origins in the late nineteenth century, establishes a classification between different types of city films, and describes the contemporary persistence and mutability of the genre.
Optimasi Pembelajaran: Strategi Meningkatkan Pemahaman Statistik melalui Pemahaman Kecerdasan Emosi, Spiritual, dan Intelektual Mahasiswa
Authors: Nofriadi Nofriadi , Pawirosumanto Suharno
Published: May 2024

Penelitian ini mengeksplorasi hubungan antara kecerdasan emosional, kecerdasan spiritual, kecerdasan intelektual, dan pemahaman statistik di kalangan mahasiswa. Dengan menggunakan pendekatan korelasional, data diperoleh dari survei yang melibatkan 128 mahasiswa dari berbagai program studi di Fakultas Ekonomi Bisnis dan Ilmu Sosial di beberapa universitas. Hasil analisis menunjukkan bahwa kecerdasan emosional, kecerdasan spiritual, dan kecerdasan intelektual secara signifikan berpengaruh terhadap pemahaman statistik mahasiswa. Lebih lanjut, kombinasi ketiga jenis kecerdasan ini memberikan manfaat yang lebih besar, dengan mahasiswa yang memiliki kecerdasan emosional, spiritual, dan intelektual yang baik cenderung memiliki keunggulan dalam pemahaman, adaptabilitas, dan prestasi akademik
The Importance of E-Worksheet Based on Problem Based Learning Activity to Improving Student's System Thinking Skills: Science Teacher's Perspective
Authors:   Department of Science Education Master Study Program, University of Lampung, Indonesia, Rifki Alhanif Muizzudin , Lengkana Dewi ,   Department of Science Education Master Study Program, University of Lampung, Indonesia, Setiyarini M. ,   Department of Science Education Master Study Program, University of Lampung, Indonesia, Herlina Kartini ,   Department of Science Education Master Study Program, University of Lampung, Indonesia
Published: May 2024

This research aims to describe the importance of learning media in the form e-worksheet with a problem-based learning model to improve students’ systems thinking skills which focuses on Energy material. The research model used is the 4D development model (Define, Design, Develop, Disseminate). This article reports on the Define stage. Data collection was taken from literature studies and distributing questionnaires via Google Form, then descriptive analysis was carried out. The teacher respondents in this research were 25 science teachers in Lampung Province. The results of the research show that 60% of the problems experienced by teachers in the field are the lack of teaching materials and learning media that are able to stimulate 21st century skills. As many as 78.3% of teachers have not trained systems thinking skills which are part of 21st century skills. Literacy study results shows the importance of learning media with problem-based learning to improve systems thinking skills.
A Comprehensive Literature Review of Marital Dissolution in the Philippines: Legal, Socio-Cultural, and Feasibility Perspectives
Authors:   Bachelor of Science in Accountancy, Institute of Accounts, Business and Finance, Far Eastern University-Manila, Sampaloc, Manila City, 1008, Metro Manila, Philippines, Grace Agliam Dorothy , Lei Bongolto Katrina ,   Bachelor of Science in Accountancy, Institute of Accounts, Business and Finance, Far Eastern University-Manila, Sampaloc, Manila City, 1008, Metro Manila, Philippines, Rigel Pobeda Gabrielle ,   Bachelor of Science in Accountancy, Institute of Accounts, Business and Finance, Far Eastern University-Manila, Sampaloc, Manila City, 1008, Metro Manila, Philippines, Jennielle Vega Princess ,   Bachelor of Science in Accountancy, Institute of Accounts, Business and Finance, Far Eastern University-Manila, Sampaloc, Manila City, 1008, Metro Manila, Philippines, D. Vallespin Mc Rollyn ,   Undergraduate Studies, Institute of Education, Far Eastern University-Manila, Sampaloc, Manila City, 1008, Metro Manila, Philippines
Published: May 2024

This research provides an overview of the topic of annulment and the possibility of divorce in the Philippines. The study used a qualitative approach through case studies to collect and identify experiences and to explore the legal framework of annulment, socio-cultural factors influencing attitudes towards annulment, the impact of annulment on individuals and families, public perceptions and stigmatization, the feasibility of introducing divorce as an alternative, and international practices and case studies of divorce. Defined by Executive Order No. 209, under the Family Code of the Philippines, outlined the grounds for annulment. Due to the country’s predominantly Catholic population, the Philippines’ socio-cultural influences have shaped the attitudes of its fellow citizens towards annulment, with an additional increasing acceptance of divorce as a practical solution. Meanwhile, impact studies show positive and negative consequences on individuals and families, showing that coping mechanisms play a crucial role in reducing difficulties. On the other hand, public perceptions and stigmatization of annulment require further research. Lastly, the feasibility of introducing divorce within the Philippines may encounter challenges due to different factors. Further research on international cases may offer additional insights into the legalization of divorce and managing its social implications. The study highlights the difficulties of ending marriages in the Philippines. The researchers wanted to recommend this work to future researchers conducting a study about divorce and the Philippine system to create support connections and legal reforms to ensure the protection and well-being of individuals and families when going through relationship changes.
Understanding the Multifaceted Impacts of Social Media Addiction on Minors: A Comprehensive Analysis of Psychological, Behavioral, and Physiological Dimensions
Authors:   Institute of Health and Sciences Medical Technology, Far Eastern University-Manila Sampaloc, Manila City, 1008, Metro Manila, Philippines, B. Purificacion Andreu Julyn , D. Vallespin Mc Rollyn ,   Undergraduate Studies, Institute of Education, Far Eastern University-Manila, Sampaloc, Manila City, 1008, Metro Manila, Philippines
Published: May 2024

Social media platforms have become ubiquitous in modern life, particularly for adolescents. This secondary research explores the impact of social media addiction on minors. Existing literature suggests a complex relationship between social media use and mental health. Studies highlight potential links between excessive use and increased anxiety, depression, and sleep disturbances in minors. Social media can also contribute to social comparison and negative body image perception. Employing a thematic analysis of data from academic journals, scholarly reports, and systematic reviews. The analysis focused on studies published within the last ten years to ensure the findings reflect the latest trends and developments in social media use and its impact on minors. Findings revealed concerning trends, including the negative impact on mental health, the potential for cyberbullying and social isolation, and the influence of family dynamics on social media addiction development. The discussion emphasizes the importance of promoting responsible social media use through open communication between parents and children, media literacy programs in schools, and content moderation efforts by social media platforms. Further research is needed to develop effective interventions and mitigate potential harm to minors’ well-being.
Reactualization of Pancasila as a Source of Indonesian Law in Realizing Justice
Authors:   Faculty of Law, Universitas Diponegoro, Jl. dr. Antonius Suroyo, Tembalang, Semarang, Indonesia, Najib Ahmad Ainun , Sutrisno Putri Ayu ,   Faculty of Law, Universitas Diponegoro, Jl. dr. Antonius Suroyo, Tembalang, Semarang, Indonesia
Published: May 2024

Pancasila, as the basis of the state, continues to experience fluctuations and challenges occasionally. As the basis of the state's view of life, Pancasila directs how the process and law are carried out to fulfill justice amid state life. This doctrinal legal research reflexively examines Pancasila as the basis of the state and the source of law. The research findings show that Pancasila is the basis of the state as well as the basis of the state's view of life, which serves as a guide in the management and structuring of the state. In the legal context, Pancasila is a legal ideal (rechtsidee) primary source of state law. Pancasila serves to ensure justice by assessing how the law is formulated and to determine the legality of a regulation. At the praxis level, the Constitutional Court, as the guardian of the state ideology, is expected to make Pancasila a touchstone in testing every regulation.
Comparative Model of Political Marketing of the Winning Team of Ganjar Pranowo- Taj Yasin with Sudirman Said-Ida Fauziah in the 2018 Central Java Election in Pati Regency
Authors:   Faculty of Social and Political Science, University of North Sumatra, Medan, Indonesia, Kusmanto Heri , Bahri Saipul ,   Faculty of Social and Political Science, University of North Sumatra, Medan, Indonesia, Sipahutar Muhammad Zubeir ,   Faculty of Social and Political Science, University of North Sumatra, Medan, Indonesia
Published: May 2024

This study is a comparative study of the political marketing model that occurred in the 2018 Central Java regional election competition in Pati Regency. The focus is on how the political marketing models run by candidates and winning teams in winning the competition, then what causes the strong competition in the election in Pati Regency. The findings of this study include four important things that are the main causes of the strong competition in running political marketing between the winning teams of candidates in Pati Regency, causing different political marketing models to be run to gain support from voters. First, the Work Program offered; Second, Campaign Presentation; Third, Political Marketing Media Channels; Fourth, Personal Branding of Candidate Leadership. The method used is a qualitative method.
The Role of Parental Support in the Relationship between Motivation and Student Learning Outcomes
Authors:   Lecturer in Masters of elementary education, FKIP Universitas Jember-Indonesia, Bektiarso Singgih , Pratiwi Gita Indah ,   Student in Masters of elementary education FKIP Universitas Jember-Indonesia, Mustikarani Tinon ,   Student in Masters of elementary education FKIP Universitas Jember-Indonesia, Mu’allimah Isyarotul ,   Student in Masters of elementary education FKIP Universitas Jember-Indonesia
Published: May 2024

The aims of this research are to measure and analyze, 1) the influence of motivation on student learning outcomes, 2) the moderating role of parental support on the influence of motivation on student learning outcomes. This type of research is quantitative research with inferential statistical tests. The population of this study were elementary education master's students at FKIP Jember University. The number of respondents involved was 37 students. Researchers collected data through a questionnaire with a Likert scale with answer choices 1-3, namely; 1. disagree; 2. agree; .3. strongly agree. The data analysis used was the SPSS version 26 application with linear regression techniques. The analysis steps that have been carried out are influence testing, moderation testing, and hypothesis testing. The research results provide information on several things. First, motivation has a significant positive effect on student learning outcomes; second, parental support significantly moderates the influence of motivation on student learning outcomes.
A remarkable case of intrauterine intussusception, ileal atresia, and complicated meconium ileus: A case report
Authors: Hencke Jonathan , Diez Oliver , Loff Steffan
Published: May 2024

Background: Intrauterine intussusception, although very rare (<2%), is a potential cause of intestinal atresia. It usually manifests as bowel obstruction during the first hours or days of life.
Case Presentation: We report a case with fetal ascites prompting early Cesarean section, with subsequent percutaneous abdominal drainage and laparotomy. Intraoperative findings showed meconium peritonitis and type IIIa ileal atresia with intussusception of the distal part, with the necrosed intussusceptum likely causing perforation and ileal atresia; in addition, the distal ileum demonstrated signs of meconium ileus. After ileostomy creation, the postoperative course was uneventful. Cystic fibrosis was excluded via a sweat test.
Conclusion: Prompt diagnosis and management of neonatal intestinal obstruction secondary to the unusual combination of fetal ascites, intussusception, complicated meconium ileus, and ileal atresia results in a favorable outcome.
Non-Secretory Macroprolactinoma Tumour Response to Dopamine Agonist Therapy in a Post Pituitary Resection Patient-A Case Report from Saudi Arabia Specialist Hospital
Authors:   Department of Endocrinology, King Abdul Aziz Specialist Hospital, Mainstay of Health Taif, Saudi Arabia, Alzaedi Ohud A , Suresh Somannavar ,   Department of Endocrinology, King Abdul Aziz Specialist Hospital, Mainstay of Health Taif, Saudi Arabia, H Alfaifi Abdulaziz ,   Department of Internal Medicine, King Abdul Aziz Specialist Hospital, Mainstay of Health, Taif, Saudi Arabia
Published: May 2024

We present a very rare case of pituitary macroprolactinoma with mildly elevated dilutional prolactin levels after post-pituitary resection and the histopathology report was strange. We noticed prolactinoma with follow-up MRI and patient had pituitary remnant of 0.7 x 0.8 mm. He was responded excellently to cabergoline.
Review on Ethical Approaches to Antimicrobial Resistance
Authors:   Department of Veterinary Public Health, Haramaya University College of Veterinary  Medicine, Ethiopia, Tadesse Debeli , Mulatu Henok ,   Livestock and Fisheries Development Offices, Habro District, Gelemso, Ethiopia, Abebe Henok ,   Hirna Regional Veterinary Laboratory, Hirna, Ethiopia, Shaf Wazir ,   Department of Veterinary Public Health, Haramaya University College of Veterinary  Medicine, Ethiopia
Published: May 2024

The world is fast approaching a time whereby people will die from infections because there are no longer any effective drugs. This will change the face of medicine, as we know it, since many modern medical procedures are highly dependent upon antimicrobial protection. This might appear to be chiefly a problem for doctors and scientists but the nature of widespread AMR embodies a large number of ethical and moral issues, influencing every aspect of infection management and potentially affecting everyone. The objectives of this review is to introduce and discuss some of the most important ethical approaches associated with AMR and its control, including national and international responsibilities, pharmaceutical companies, prescribing, education, advertising, veterinary and agricultural practices, infection control and patient behaviour. Given the enormous importance of antimicrobial drugs for the functioning and delivery of modern health care, the progressive exhaustion of effective antibiotics presents health care professionals and policy makers with a distributive dilemma that raises complex moral questions of justice, especially how to fairly allocate antimicrobial resources.
Dynamic Pricing Model for E-commerce Products Based on DDQN
Authors: Sun Junyan , Wang Zihao , Qiao Zheng , Li Xiaopeng
Published: May 2024

This paper addresses the challenges of intense price competition, price elasticity, and significant demand fluctuations in e-commerce product markets by adopting a dynamic pricing approach. Focusing on a product from the JD.com e-commerce platform, historical data spanning the past three years are analyzed, considering factors such as shipping costs, product inventory, product costs, and the impact of holidays. The study employs the Double Deep Q-Network (DDQN) for dynamic pricing optimization of the product, and compares its performance with the Deep Q-Network (DQN) model. The results indicate that both the DQN algorithm and DDQN algorithm lead to varying degrees of profit improvement for the dynamic pricing of products. Specifically, the pricing profit with the DQN algorithm increased by an average of 1.925% compared with the original pricing profit, while the pricing profit with the DDQN algorithm increased by an average of 11.975% compared with the original pricing profit. These findings demonstrate practical significance.
 
Received: 6 March 2024 | Revised: 1 April 2024 | Accepted: 28 April 2024
 
Conflicts of Interest 
The authors declare that they have no conflicts of interest to this work.
 
Data Availability Statement
The data that support this work are available upon reasonable request to the corresponding author.
 
Author Contribution Statement
Junyan Sun: Conceptualization, Supervision, Project administration, Funding acquisition. Zihao Wang: Methodology, Software, Formal analysis, Investigation, Writing – original draft, Writing – review & editing. Zheng Qiao: Data curation, Visualization. Xiaopeng Li: Validation, Resources, Writing – review & editing.
A Five–Year Review of Cases Referred to the Genetics Clinic, PGH for Findings of Congenital Anomalies on Prenatal Ultrasound
Authors: Abarquez Conchita G. , Alcausin Maria Melanie B. , David-Padilla Carmencita , Cutiongco-de la Paz Eva Maria
Published: May 2024

...
Distinction of measures of Haar cylinders in the Dirichlet theorem for the field of p-adic numbers
Authors:   Institute of Mathematics, National Academy of Sciences of Belarus, Bernik V.I. , Kudin A.S. ,   Institute of Mathematics, National Academy of Sciences of Belarus, Titova A.V.
Published: May 2024

The Dirichlet box principle gives surprisingly accurate results in problems of approximation of real numbers by rational numbers, transcendental numbers by real algebraic numbers. Every polynomial taking small values at a given point $x$ also takes small values in its neighborhood. A problem of studying such neighborhoods and obtaining possible Lebesgue measure values arises frequently. In this paper we solve the problem in the p-adic case using recent results of the metric theory of Diophantine approximations.
Innovations, Best Practices, and Distinctiveness in Higher Education Administration – A Case of Srinivas University
Authors: Aithal P. S. , Maiya Adithya Kumar , P. S. Nethravathi , Aithal Shubhrajyotsna , DeMello Laveena
Published: May 2024

Purpose: Research in "Innovations, Best Practices, and Distinctiveness in Higher Education Administration" through case studies of universities aims to identify novel approaches, successful strategies, and unique initiatives implemented by higher education institutions. By analyzing these case studies, researchers can uncover innovative practices that contribute to institutional excellence and effectiveness in administration. Ultimately, the research seeks to disseminate valuable insights and lessons learned to improve higher education administration and foster continuous improvement across universities.
Methodology: Exploratory research methodology is used where required information are collected through keyword-based search using Srinivas University website, Google search engine, Google scholar search engine, and AI-driven GPT MLM search engines.
Analysis & Interpretation: Ther information collected from relevant sources are analysed, compared, evaluated, and interpreted using various frameworks. This includes innovations and best practices in infrastructure administration, Innovations and best practices in Library Administration, Innovations and best practices in Maintenance of Campus Infrastructure, Innovations and best practices in Alumni Engagement, Innovations in Vison and Leadership, Innovations in the development of Institutional Strategic Plan, Innovations in Effectiveness of Administration, Innovations in Faculty Empowerment Strategies, Innovations in Financial Management and Resource Mobilization, and Innovations, best practices, and institutional distinctiveness in Internal Quality Assurance System.
Originality/Value addition: Based on the analysis some Suggestions on Innovations, Best Practices and Distinctiveness in Administrative related Activities are provided. By implementing the suggestions systematically, the university can realise its dream to become one among many world-class universities.
Type of Paper: Case study based scholarly research analysis
Endoscopic Third Ventriculostomy versus Ventriculo-Peritoneal Shunt for Infant Hydrocephalus
Authors: Muhammad Irshad  , Choudhary Ali Manzoor  , Malik Liaqat Ali Jalal
Published: May 2024

Objective: To compare the outcome of ventriculo-peritoneal shunt (VP shunt) versus endoscopic third ventriculostomy (ETV) as surgical intervention in management of Infant hydrocephalus.
Methodology: A prospective, randomized controlled trial was conducted at the department of Neurosurgery Nishtar University Hospital between June 2023 and November 2023. Study was conducted on 62 pediatric patients with hydrocephalus, all fewer than two years of age, who underwent cerebrospinal fluid (CSF) diversion through either endoscopic third ventriculostomy (ETV) or ventriculoperitoneal (VP) shunt placement. Patients were randomly assigned to one of two treatment groups: ETV or VP shunt. Randomization was done using a computer-generated sequence to ensure unbiased allocation. The ETV group underwent endoscopic surgery to create an opening in the third ventricle to allow CSF to bypass the obstruction. The VP shunt group received a surgically implanted device to divert CSF from the ventricles to the peritoneal cavity.
Results: Infection was higher in Group VP than Group ETV as 5 (16.1%) and 1 (3.2%), respectively, (p=0.086). Similarly, obstruction was higher in Group VP than Group ETV as 11 (35.5%) and 9 (29.0%), respectively, (p=0.587). Whereas, surgery was revised 16 (51.6%) in Group VP and 13 (41.9%) in Group Erate TV, (p=0.445).
Conclusion: This suggests that ETV presents as a favorable alternative to VP shunt placement due to its reduced risk of postoperative complications and quicker operative duration, while still maintaining comparable efficacy in terms of preventing obstruction, and the necessity for revision surgeries.
Unveiling the Novel Impact of Vitamin D Injections at Birth on the Prognosis of Newborns: A Double-blind Study
Authors: Boskabadi Hassan , Sadeghi Tahereh , Mostafavi Mina
Published: May 2024

Objectives: Vitamin D deficiency can harm both the infant and the mother, potentially altering the trajectory of the child’s life. This study aimed to delve into the potentially life-changing impact of vitamin D intake at birth on the prognosis of premature newborns. Methods: We conducted a double-blind, randomized clinical trial study, between 2021–2022, including 100 infants admitted to the neonatal intensive care unit of Ghaem Hospital in Mashhad, Iran. Premature infants with a gestational age of < 34 weeks and requiring the neonatal intensive care unit admission were randomly allocated into two groups. The intervention group consisted of infants who received 10 000 units of vitamin D, while the control group comprised infants who did not receive any vitamin D at birth. The infants were evaluated based on clinical symptoms, the requirement and duration of oxygen therapy, the necessity and length of mechanical ventilation, the method of oxygen therapy administered, and the length of their hospital stay. Results: This study included 56 (56.0%) boys and 44 (44.0%) girls. A significant difference was observed between the intervention and control groups regarding maternal age frequency (p =0.013). Additionally, the frequency of mechanical ventilation (p =0.030), surfactant administration (p =0.009), and the number of times surfactant was administered (p =0.020) also showed significant differences between both groups. Conclusions: Vitamin D intake at birth could potentially revolutionize the management of respiratory complications in premature infants, a crucial discovery for healthcare practitioners and researchers.
Study on the Construction and Realization Path of Political Elements in College Basketball Course
Authors:   Asia Social Science Academy, l l , l l , l l
Published: May 2024

The proposal of “curriculum thought and politics” has put forward new requirements and new challenges to college physical education. How to integrate the rich political ideas contained in physical education into daily teaching has also brought new problems and new opportunities to physical education classroom. This research mainly uses the literature method, firstly expounds the necessity of political elements of college basketball course, and then sorts out the political elements of college basketball course. It believes that college basketball course contains political elements such as patriotic consciousness, teamwork consciousness and trust consciousness, competition consciousness and hard work consciousness, rule consciousness and calm quality. Finally, it puts forward the realization path from the aspects of strengthening teachers' education consciousness and ability, reforming and innovating traditional teaching contents and teaching methods, creating a good curriculum political environment, and configuring and constructing the corresponding mechanism for PE teachers to carry out curriculum political development.
Secondary ice production – no evidence of efficient rime-splintering mechanism
Authors: Seidel Johanna S. , Kiselev Alexei A. , Keinert Alice , Stratmann Frank , Leisner Thomas , Hartmann Susan
Published: May 2024

Abstract. Mixed-phase clouds are essential for Earth’s weather and climate system. Ice multiplication via secondary ice production (SIP) is thought to be responsible for the observed strong increase in ice particle number concentration in mixed-phase clouds. In this study, we focus on the rime splintering also known as the Hallett–Mossop (HM) process, which still lacks physical and quantitative understanding. We report on an experimental study of rime splintering conducted in a newly developed setup under conditions representing convective mixed-phase clouds in the temperature range of −4 to −10 °C. The riming process was observed with high-speed video microscopy and infrared thermography, while potential secondary ice (SI) particles in the super-micron size range were detected by a custom-built ice counter. Contrary to earlier HM experiments, where up to several hundreds of SI particles per milligram of rime were found at −5 °C, we found no evidence of productive SIP, which fundamentally questions the importance of rime splintering. Further, we could exclude two potential mechanisms suggested to be the explanation for rime splintering: the freezing of droplets upon glancing contact with the rimer and the fragmentation of spherically freezing droplets on the rimer surface. The break-off of sublimating fragile rime spires was observed to produce very few SI particles, which is insufficient to explain the large numbers of ice particles reported in earlier studies. In the transition regime between wet and dry growth, in analogy to phenomena of the deformation of drizzle droplets upon freezing, we also observed the formation of spikes on the rimer surface, which might be a source of SIP.
Intercomparison of eddy-covariance software for urban tall-tower sites
Authors: Lan Changxing , Mauder Matthias , Stagakis Stavros , Loubet Benjamin , D'Onofrio Claudio , Metzger Stefan , Durden David , Herig-Coimbra Pedro-Henrique
Published: May 2024

Abstract. Long-term tall-tower eddy-covariance (EC) measurements have been recently established in three European pilot cities as part of the ICOS-Cities project. We conducted a comparison of EC software to ensure a reliable generation of interoperable flux estimates, which is the prerequisite for avoiding methodological biases and improving the comparability of the results. We analyzed datasets covering 5 months collected from EC tall-tower installations located in urbanized areas of Munich, Zurich, and Paris. Fluxes of sensible heat, latent heat, and CO2 were calculated using three software packages (i.e., TK3, EddyPro, and eddy4R) to assess the uncertainty of flux estimations attributed to differences in implemented postprocessing schemes. A very good agreement on the mean values and standard deviations was found across all three sites, which can probably be attributed to a uniform instrumentation, data acquisition, and preprocessing. The overall comparison of final flux time series products showed a good but not yet perfect agreement among the three software packages. TK3 and EddyPro both calculated fluxes with low-frequency spectral correction, resulting in better agreement than between TK3 and the eddy4R workflow with disabled low-frequency spectral treatment. These observed flux discrepancies indicate the crucial role of treating low-frequency spectral loss in flux estimation for tall-tower EC systems.
Extraction, purification, and clumped isotope analysis of methane (Δ13CDH3 and Δ12CD2H2) from sources and the atmosphere
Authors: Sivan Malavika , Röckmann Thomas , van der Veen Carina , Popa Maria Elena
Published: May 2024

Abstract. Measurements of the clumped isotope anomalies (Δ13CDH3 and Δ12CD2H2) of methane have shown potential for constraining methane sources and sinks. At Utrecht University, we use the Thermo Scientific Ultra high-resolution isotope-ratio mass spectrometer to measure the clumped isotopic composition of methane emitted from various sources and directly from the atmosphere. We have developed an extraction system with three sections for extracting and purifying methane from high (> 1 %), medium (0.1 % to 1 %), and low-concentration (< 0.1 %) samples, including atmospheric air (∼ 2 ppm = 0.0002 %). Depending on the methane concentration, a quantity of sample gas is processed that delivers 3 ± 1 mL of pure methane, which is the quantity typically needed for one clumped isotope measurement. For atmospheric air with a methane mole fraction of 2 ppm, we currently process up to 1100 L of air. The analysis is performed on pure methane, using a dual-inlet setup. The complete measurement time for all isotope signatures is about 20 h for one sample. The mean internal precision values of sample measurements are 0.3 ± 0.1 ‰ for Δ13CDH3 and 2.4 ± 0.8 ‰ for Δ12CD2H2. The long-term reproducibility, obtained from repeated measurements of a constant target gas, over almost 3 years, is around 0.15 ‰ for Δ13CDH3 and 1.2 ‰ for Δ12CD2H2. The measured clumping anomalies are calibrated via the Δ13CDH3 and Δ12CD2H2 values of the reference CH4 used for the dual-inlet measurements. These were determined through isotope equilibration experiments at temperatures between 50 and 450 °C. We describe in detail the optimized sampling, extraction, purification, and measurement technique followed in our laboratory to measure the clumping anomalies of methane precisely and accurately. This paper highlights the extraction and one of the first global measurements of the clumping anomalies of atmospheric methane.