bluuebunny/crossref_metadata_2025 huggingface dataset:
Identifying and Validating Genes with DNA Methylation Data in the Context of Biological Network for Chinese Patients with Graves’ Orbitopathy
Authors: Shi Ting-Ting , Hua Lin , Xin Zhong , Li Yu , Liu Wei , Yang Yi-Lin
Published: March 2019

Aim. This study investigated the association of DNA methylation with Graves’ orbitopathy (GO) incidence through a combined analysis in the context of biological network to identify and validate potential genes for Chinese patients with GO.Methods. A genome-scale screening of DNA methylation was performed on the peripheral blood sample of six patients with GO and six controls. After extracting differentially methylated regions (DMRs), the study focused on two classes of genes with obviously different methylation levels: low methylated genes (LMGs) and high methylated genes (HMGs). Mutual information was applied to construct LMG- and HMG-regulated networks, and the top 10 LMGs and HMGs were extracted based on the topological properties. Then, 9 candidate genes were extracted to validate their association with GO in an expanded population (48 patients with GO vs. 24 normal controls) using single-cell methylation sequencing.Results. In the LMG-regulated network, some LMGs displayed a higher degree, such as HIST1H2AL, EFCAB1, and BOLL. Similarly, in the HMG-regulated network, some HMGs, such as MBP, ANGEL1, and LYAR, also showed a higher degree. For validation using an enlarged population, BOLL still displayed the lower methylation level whereas CDK5 and MBP still displayed the higher methylation level in patients with GO in the multivariable logistic regression analysis adjusted by age and gender (P<0.01).Conclusions. BOLL, CDK5, and MBP are potential genes associated with GO. This study was novel in clinically investigating the relation of these genomic loci with GO. The findings might provide new insights into understanding this disease.
A Continuum Approach to the Nonlinear In-Plane Galloping of Shallow Flexible Cables
Authors: Ferretti M. , Zulli D. , Luongo A.
Published: March 2019

The aeroelastic stability of horizontal, suspended, shallow, iced cables is studied via a continuum model. Both external and internal damping, consistent with the Rayleigh model, are taken into account. The quasi-static theory of the aerodynamic forces is applied. An in-plane nonlinear model of galloping is formulated, displaying the importance of internal damping, both on the critical velocity and on the limit-cycle amplitude. A perturbation procedure is developed for nonlinear analysis in nonresonant conditions (monomodal galloping). The modification of the galloping mode due to quadratic nonlinearities is studied, and its real or complex character is discussed.
Bond Behavior of Reinforcing Steel Bars in Thermal Insulation Concrete Exposed to Freeze-Thaw Cycles
Authors: Tu Jinsong , Zhou Ming , Liu Yuanzhen , Chen Y. Frank
Published: March 2019

An experimental study on the bond behavior of reinforcing steel bars in thermal insulation concrete (TIC) mixed with glazed hollow beads (GHBs) and exposed to freeze-thaw (F-T) cycles was carried out. In order to investigate the effects of GHBs on freezing and thawing, the experimental results were compared with those of normal concrete (NC). The comparison shows that, after 300 F-T cycles, both bond behavior and mechanical properties of the TIC specimens are better than those of the NC specimens. Furthermore, in order to investigate the mechanism of frost effect on TIC, the CT scanning method was used to investigate the evolution of the inner structure of a TIC specimen exposed to F-T cycles. The CT images show that the deterioration of bond performance and mechanical properties of the TIC specimen appears to be caused by the increase of micropores in the TIC.
Fabrication of an Original Transparent PVA/Gelatin Hydrogel: In Vitro Antimicrobial Activity against Skin Pathogens
Authors: Imtiaz Naila , Niazi Muhammad Bilal Khan , Fasim Fehmida , Khan Barkat Ali , Bano Syeda Asma , Shah Ghulam Mujtaba , Badshah Malik , Menaa Farid , Uzair Bushra
Published: March 2019

The design of actively efficient and low-toxicity formulations against virulent bacterial strains causing skin infections remains a challenging task. The aim of the present study was to develop and evaluate in vitro a hydrogel impregnated with a known plant extract for topical applications against major skin bacteria. A poly(vinyl alcohol) (PVA)/gelatin hydrogel, namely HG, was prepared by esterification following the solution casting method. The gelling process was realized by cross-linking the synthetic polymer PVA and the biopolymer gelatin in the presence of hydrochloric acid (HCl). A crude extract of Nigella sativa seeds was then encapsulated in HG, and the resulting HGE was characterized morphologically (by Scanning Electron Microscopy (SEM)), structurally (by X-ray powder diffraction (XRD) and Fourier Transform Infrared (FTIR) spectroscopy), behaviorally (by swelling behavior), and biologically (by the agar well diffusion method). The results of HGE were compared to HG and HG impregnated with 10% acetic acid (HGAA). SEM sections of HGE revealed a dense and porous surface, suggesting a good hydrophilicity. X-ray diffractograms indicated that HGE and HG had a similar degree of crystallinity. FTIR spectra confirmed that esterification occurred between PVA and gelatin suggesting that the amine group is involved in the intercalation of the plant extract components in HG. Further, HGE was found to be as wettable and swellable as HG, suggesting a good biocompatibility. Eventually, HGE exerted a pronounced inhibitory effect against two major skin pathogens, the Gram-negative Pseudomonas aeruginosa and the Gram-positive Staphylococcus aureus, suggesting a good extract release. Taken together, the experimental data indicated that HGE might be a promising wound dressing.
Laboratory Study on Core Fracturing Simulations for Wellbore Strengthening
Authors: Ma Biao , Pu Xiaolin , Zhao Zhengguo , Wang Hao , Dong Wenxin
Published: March 2019

The lost circulation in a formation is one of the most complicated problems that have existed in drilling engineering for a long time. The key to solving the loss of drilling fluid circulation is to improve the pressure-bearing capacity of the formation. The tendency is to improve the formation pressure-bearing capacity with drilling fluid technology for strengthening the wellbore, either to the low fracture pressure of the formation or to that of the naturally fractured formation. Therefore, a laboratory study focused on core fracturing simulations for the strengthening of wellbores was conducted with self-developed fracture experiment equipment. Experiments were performed to determine the effect of the gradation of plugging materials, kinds of plugging materials, and drilling fluid systems. The results showed that fracture pressure in the presence of drilling fluid was significantly higher than that in the presence of water. The kinds and gradation of drilling fluids had obvious effects on the core fracturing process. In addition, different drilling fluid systems had different effects on the core fracture process. In the same case, the core fracture pressure in the presence of oil-based drilling fluid was less than that in the presence of water-based drilling fluid.
Optimization of Semiautomated Calibration Algorithm of Multichannel Electrotactile Feedback for Myoelectric Hand Prosthesis
Authors: Isaković Milica , Malešević Jovana , Keller Thierry , Kostić Miloš , Štrbac Matija
Published: March 2019

The main drawback of the commercially available myoelectric hand prostheses is the absence of somatosensory feedback. We recently developed a feedback interface for multiple degrees of freedom myoelectric prosthesis that allows proprioceptive and sensory information (i.e., grasping force) to be transmitted to the wearer instantaneously. High information bandwidth is achieved through intelligent control of spatiotemporal distribution of electrical pulses over a custom-designed electrode array. As electrotactile sensations are location-dependent and the developed interface requires that electrical stimuli are perceived to be of the same intensity on all locations, a calibration procedure is of high importance. The aim of this study was to gain more insight into the calibration procedure and optimize this process by leveraging a priori knowledge. For this purpose, we conducted a study with 9 able-bodied subjects performing 10 sessions of the array electrode calibration. Based on the collected data, we optimized and simplified the calibration procedure by adapting the initial (baseline) amplitude values in the calibration algorithm. The results suggest there is an individual pattern of stimulation amplitudes across 16 electrode pads for each subject, which is not affected by the initial amplitudes. Moreover, the number of user actions performed and the time needed for the calibration procedure are significantly reduced by the proposed methodology.
Hepatitis B Virus Infection is a Prognostic Biomarker for Better Survival in Operable Esophageal Cancer: Analysis of 2,004 Patients from an Endemic Area in China
Authors: Zou Jianyong , Chen Junying , Xie Xuan , Liu Zhengguo , Cai Xiaoli , Liu Qianwen , Wen Jing , Zhang Shuishen
Published: March 2019

Background:

Hepatitis B Virus (HBV) infection has been proven to be associated with the survival of many cancers. However, the prevalence and prognostic value of HBV infection in esophageal cancer has not been investigated yet.

Methods:

A total of 2,004 consecutive esophageal cancer patients who underwent esophagectomy between 2000 and 2008 were recruited in our study. ELISA was used to test serum HBV markers. Patients were divided into HBsAg-positive group (HBV infection) and HBsAg-negative group. The impact of HBV infection on disease-free survival (DFS) and overall survival (OS) was estimated using the Kaplan–Meier method and Cox proportional hazard models.

Results:

HBV infection was found in 12.6% (253/2,004) of patients. HBsAg-positive patients had significantly higher percentage of early pathologic T stage, lower frequency of liver metastasis, and extrahepatic metastasis than HBsAg-negative. HBsAg-positive patients had a favorable DFS [HR = 0.79; 95% confidence interval (CI): 0.66–0.94, P = 0.007) and OS (HR = 0.80; 95% CI: 0.65–0.95, P = 0.020] respectively, when compared with HBsAg-negative patients. Subgroup analysis showed that the association with HBV infection and better DFS and OS was observed in patients with esophageal squamous cell carcinoma and advanced pathologic stage (III–IV).

Conclusion: HBV infection was an independent favorable prognostic factor for survival in operable esophageal cancer.

Impact:

Our large cohort study provided more definite and quantitative evidence that HBV infection is an independent favorable prognostic biomarker in patients with esophageal cancer, especially in patients with esophageal squamous cell carcinoma and advanced pathologic stage (III–IV).
TAS-121, A Selective Mutant EGFR Inhibitor, Shows Activity Against Tumors Expressing Various EGFR Mutations Including T790M and Uncommon Mutations G719X
Authors: Ito Kimihiro , Nishio Makoto , Kato Masanori , Murakami Haruyasu , Aoyagi Yoshimi , Ohe Yuichiro , Okayama Takashige , Hashimoto Akihiro , Ohsawa Hirokazu , Tanaka Gotaro , Nonoshita Katsumasa , Ito Satoru , Matsuo Kenichi , Miyadera Kazutaka
Published: March 2019

TAS-121 is a novel orally active selective covalent inhibitor of the mutant EGFR. We performed preclinical characterization of TAS-121 and compared its efficacy and selectivity for common EGFR mutations (Ex19del and L858R), first- and second- generation EGFR-tyrosine kinase inhibitor (EGFR-TKI) resistance mutation (T790M), and uncommon mutations (G719X and L861Q) with those of other EGFR-TKIs. We also commenced investigation of the clinical benefits of TAS-121. The IC50 for intracellular EGFR phosphorylation was determined by using Jump-In GripTite HEK293 cells transiently transfected with EGFR expression vectors. Mouse xenograft models were used to evaluate the antitumor activity of TAS-121. TAS-121 potently inhibited common activating and resistance EGFR mutations to the same extent as another third-generation EGFR-TKI (osimertinib). In addition, TAS-121 showed equivalent inhibitory activity against some uncommon mutations such as G719X and L861Q. Furthermore, TAS-121 demonstrated greater selectivity for mutant EGFRs versus the wild-type EGFR compared with other EGFR-TKIs. Moreover, TAS-121 displayed antitumor activity in SW48 (EGFR G719S) and NCI-H1975 (EGFR L858R/T790M) xenograft models, and achieved an objective response in patients with NSCLC with EGFR mutations including G719A mutation. In conclusion, TAS-121 is a novel third-generation EGFR-TKI and demonstrates antitumor activities in patients with NSCLC expressing either common or uncommon EGFR mutations.
Age of Onset of Diabetes and Its Comparison with Prevalence and Risk Factors for Diabetic Retinopathy in a Rural Population of India
Authors: Khan Rehana , Singh Sumeer , Surya Janani , Sharma Tarun , Kulothunga Vaitheeswaran , Raman Rajiv
Published: March 2019

Aim: To compare the age of onset of diabetes with the prevalence and risk factors of diabetic retinopathy (DR) in a rural population of India. Methods: This is a population-based study for which 1,190 people with diabetes were recruited from rural areas of the districts of Kanchipuram and Thiruvallur, Tamil Nadu, India. The fundi of all patients were photographed using a 45°, four-field stereoscopic digital fundus camera. The diagnosis of DR was based on the Klein classification of the Early Treatment Diabetic Retinopathy Study scale. Results: The prevalence of DR was 11.5% in individuals with known onset of diabetes (aged ≤40 years) compared to 10.0% in those with late onset. The risk factors for any DR in both groups included longer known duration of diabetes, use of insulin, and the presence of high systolic blood pressure and hypertension. In the group with known onset of diabetes at ≤40 years, older age (p < 0.0001) and male gender (p = 0.018) were the significant factors for DR. In the group with age of onset of diabetes at > 40 years, high diastolic pressure (p = 0.001), higher HbA1c (p < 0.0001), high microalbuminuria (p < 0.0001), and high macroalbuminuria (p < 0.008) were the significant risk factors for DR. Conclusion: Control of risk factors in people with younger age of onset of diabetes may reduce both the prevalence and impact of retinopathy in rural populations.
Genetic Polymorphisms and Susceptibility to Sudden Sensorineural Hearing Loss: A Systematic Review
Authors: Cao Zaizai , Gao Jinjian , Huang Saiyu , Xiang Haijie , Zhang Chuqin , Zheng Bo , Zhan Xiang , Chen Ruru , Chen Bobei
Published: March 2019

Background: Recently, genetic factors have been considered as an important risk factor for sudden sensorineural hearing loss (SSNHL). Many studies analyzed the association between SSNHL and polymorphisms. However, most of them gave inconclusive results. Key Message: We performed a systematic review to find out the association between polymorphisms and susceptibility to SSNHL. Finally, 47 studies involving 5,230 SSNHL patients and 68 genes were included for analysis and discussion of results. Polymorphisms in 26 genes have been suggested to be correlated with the susceptibility to SSNHL. Summary: Although a great number of studies support that polymorphisms in genes are associated with susceptibility to SSNHL, we need large multicenter studies, which evaluate multiple single nucleotide polymorphisms in SSNHL patients, to find real genetic risk factors for susceptibility to SSNHL. This is very helpful in designing more effective prevention and treatment strategies for patients with SSNHL.
Follicular Map: A Novel Approach to Quantitative Trichoscopy
Authors: Kasprzak Michal , Sicińska Justyna , Tosti Antonella
Published: March 2019

Background: Trichoscopy (hair and scalp dermoscopy) is gaining importance as an easy-to-use diagnostic and monitoring tool in various hair and scalp conditions. Objective: The demand for a method to identify exactly the same site on scalp skin for subsequent examinations is growing constantly. Methods: In total, 40,000 trichoscopic images of 70-fold magnification were analyzed. Graphical pattern recognition was used to identify hair shafts in trichoscopy images and to derive the coordinates of all follicular orifices. Determination of the relative positions of hair follicle orifices formed the Follicular Map (FMap). Processing and matching of FMaps involves conceptually simple but computationally complex numerical algorithms. Results: FMaps were shown to be unique for specific locations on the scalp in each human individual. The follicular patterns were not affected by natural hair cycling processes and remained unchanged over the course of time. It has been tentatively verified that FMaps remain unaffected by noncicatricial alopecia. Conclusions: The concept of FMap presents a novel approach to qualitative trichoscopy, allowing precise evaluation of treatment efficiency, clinical trial quality control, validation of diagnostic tools, and potentially other applications still to be discovered. The FMap enables the location of hair follicles to be precisely measured and recorded.
New Model of Automated Patient-Reported Outcomes Applied in Atrial Fibrillation
Authors: Hussein Ayman A. , Lindsay Bruce , Madden Ruth , Martin David , Saliba Walid I. , Tarakji Khaldoun G. , Saqi Bilal , Rausch David J. , Dresing Thomas , Callahan Thomas , Chung Mina K. , Baranowski Bryan , Bhargava Mandeep , Cantillon Daniel , Rickard John , Kanj Mohamed , Tchou Patrick , Wilkoff Bruce L. , Nissen Steven E. , Wazni Oussama M.
Published: March 2019

Background

The value of patient-reported outcomes (PRO) is increasingly recognized in patient-centered care. Longitudinal data collection may be challenging and cost prohibitive. Automation of PRO collection may complement routine clinical follow-up, especially for procedures aiming to improve quality of life, such as atrial fibrillation (AF) ablation.

Methods

We aimed to develop a fully automated platform to collect PRO and evaluate its first clinical application in a prospective cohort of AF ablation. The duration of follow-up and data availability were assessed with automated PRO and routine follow-up versus routine follow-up alone (primary outcome). Quality of life and healthcare utilization (secondary outcomes) by PRO were assessed.

Results

Between 2013 and 2016, 2175 patients were eligible to receive 10 903 PRO assessment invitations, and the automated platform sent all invitations as programmed. More follow-up assessments were obtained with automated PRO and routine follow-up compared with routine follow-up alone (12 859 versus 10 248;
P
<0.0001) which allowed longer duration of follow-up (378 versus 217 days, 74% increase;
P
<0.0001). By automated PRO, a large number of disease-specific variables were collected and showed improvement in quality of life (baseline median AF symptom severity score AFSSS of 12 [6–18] and ranged between 2 and 3 on subsequent assessments;
P
<0.0001). This improvement was also true for each of the AFSSS individual components (
P
<0.0001). In PRO, there was a significant reduction in AF burden (such as frequency and duration of episodes;
P
<0.0001) and associated healthcare utilization (including emergency visits and hospitalizations;
P
<0.0001) after the ablation procedures.

Conclusions

A fully automated system for PRO collection enhanced clinical follow-up and allowed collection of disease-specific data when applied in a prospective cohort of AF ablation.
Degradation of Glycocalyx and Multiple Manifestations of Endothelial Dysfunction Coincide in the Early Phase of Endothelial Dysfunction Before Atherosclerotic Plaque Development in Apolipoprotein E/Low‐Density Lipoprotein Receptor‐Deficient Mice
Authors: Bar Anna , Targosz‐Korecka Marta , Suraj Joanna , Proniewski Bartosz , Jasztal Agnieszka , Marczyk Brygida , Sternak Magdalena , Przybyło Magdalena , Kurpińska Anna , Walczak Maria , Kostogrys Renata B. , Szymonski Marek , Chlopicki Stefan
Published: March 2019

Background

The impairment of endothelium‐dependent vasodilation, increased endothelial permeability, and glycocalyx degradation are all important pathophysiological components of endothelial dysfunction. However, it is still not clear whether in atherosclerosis, glycocalyx injury precedes other features of endothelial dysfunction or these events coincide.

Methods and Results

Herein, we demonstrate that in 4‐ to 8‐week‐old apolipoprotein E/low‐density lipoprotein receptor‐deficient mice, at the stage before development of atherosclerotic plaques, impaired acetylcholine‐induced vasodilation, reduced NO production in aorta, and increased endothelial permeability were all observed; however, flow‐mediated dilation in the femoral artery was fully preserved. In 4‐week‐old mice, glycocalyx coverage was reduced and endothelial stiffness was increased, whereas glycocalyx length was significantly decreased at 8 weeks of age. Early changes in endothelial function were also featured by increased plasma concentration of biomarkers of glycocalyx disruption (endocan), biomarkers of endothelial inflammation (soluble vascular cell adhesion molecule 1), increased vascular permeability (angiopoietin 2), and alterations in hemostasis (tissue plasminogen activator and plasminogen activator inhibitor 1). In 28‐week‐old mice, at the stage of advanced atherosclerotic plaque development, impaired NO production and nearly all other features of endothelial dysfunction were changed to a similar extent, compared with the preatherosclerotic plaque phase. The exceptions were the occurrence of acetylcholine‐induced vasoconstriction in the aorta and brachiocephalic artery, impaired flow‐mediated vasodilation in the femoral artery, and further reduction of glycocalyx length and coverage with a concomitant further increase in endothelial permeability.

Conclusions

In conclusion, even at the early stage before the development of atherosclerotic plaques, endothelial dysfunction is a complex multifactorial response that has not been previously appreciated.
Decision Analysis Model for Prehospital Triage of Patients With Acute Stroke
Authors: Xu Yaqian , Parikh Neal S. , Jiao Boshen , Willey Joshua Z. , Boehme Amelia K. , Elkind Mitchell S.V.
Published: March 2019

Background and Purpose—

We used a decision analysis approach to analyze triage strategies for patients with acute stroke symptoms while accounting for prehospital large vessel occlusion (LVO) screening methods and key time metrics.

Methods—

Our decision analysis compared anticipated functional outcomes for patients within the IV-tPA (intravenous tissue-type plasminogen activator) treatment window in the mothership and drip-and-ship frameworks. Key branches of the model included IV-tPA eligibility, presence of an LVO, and endovascular therapy eligibility. Our decision analysis evaluated 2 prehospital LVO screening approaches: (1) no formal screening and (2) the use of clinical LVO screening scales. An excellent outcome was defined as modified Rankin Scale scores 0–1. Probabilities and workflow times were guideline-based or imputed from published studies. In sensitivity analyses, we individually and jointly varied transport time to the nearest primary stroke center, additional time required to transport directly to a comprehensive stroke center, and LVO screening scale predictive probabilities. We evaluated 2 separate scenarios: one in which ideal time metrics were achieved and one under current real-world metrics.

Results—

In the ideal metrics scenario, the drip-and-ship strategy was almost always favored in the absence of formal LVO screening. For patients screened positive for an LVO, mothership was favored if the additional transport time to the comprehensive stroke center was <3 to 23 minutes. Under real-world conditions, in which primary stroke center workflow is slower than ideal, the mothership strategy was favored in more scenarios, regardless of formal LVO screening. For example, mothership was favored with an additional transport time to the comprehensive stroke center of <32 to 99 minutes for patients screened positive for an LVO and <28 to 39 minutes in the absence of screening.

Conclusions—

Joint consideration of LVO probability, screening, workflow times, and transport times may improve prehospital stroke triage. Drip-and-ship was more favorable when more ideal primary stroke center workflow times were modeled.
Deferral of Consent in Acute Stroke Trials
Authors: Shamy Michel C.F. , Dewar Brian , Chevrier Stephanie , Wang Chu-Qi , Page Stacey , Goyal Mayank , Demchuk Andrew M. , Hill Michael D.
Published: March 2019

Background and Purpose—

The ESCAPE trial (The Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times) was a multicentre, randomized controlled trial of endovascular thrombectomy versus standard care for patients with acute ischemic stroke that allowed patients to be enrolled with deferred consent. We investigated the knowledge and opinions of these patients or their authorized third parties about the consent process.

Methods—

All patients (or their authorized third parties) enrolled with deferral of consent in ESCAPE were invited to complete a 12-question survey within the first 4 days of enrollment and again at 90 days. Questions investigated knowledge of the ESCAPE trial and opinions on deferral of consent.

Results—

Of 56 patients enrolled with deferred consent, 33 (59%) completed the initial survey, and of these, 27 (81%) completed the 90-day follow-up. Enrollment with deferred consent was not associated with a significant difference in door-to-randomization times (50.5 versus 57 minutes;
P
=0.29) but allowed these 56 patients to participate in the trial. Only 52% of respondents understood that patients could be randomized to thrombectomy or standard care, although most understood the other basic principles of the trial. At baseline and at 90 days, respondents disagreed or strongly disagreed with deferred consent in acute stroke trials generally (82% and 78%) and in the ESCAPE trial specifically (93% and 91%).

Conclusions—

Respondents generally disagreed with the use of deferred consent for enrollment in the ESCAPE trial and in stroke trials more generally.
Comparative Effectiveness of Endovascular Thrombectomy in Elderly Stroke Patients
Authors: Malhotra Ajay , Wu Xiao , Payabvash Seyedmehdi , Matouk Charles C. , Forman Howard P. , Gandhi Dheeraj , Sanelli Pina , Schindler Joseph
Published: March 2019

Background and Purpose—

Strokes in patients aged ≥80 years are common, and advanced age is associated with relatively poor poststroke functional outcome. The current guidelines do not recommend an upper age limit for endovascular thrombectomy (EVT). The purpose of this study is to evaluate the effectiveness of EVT in acute stroke because of large vessel occlusion for elderly patients >age 80 years.

Methods—

A Markov decision analytic model was constructed from a societal perspective to evaluate health outcomes in terms of quality-adjusted life years (QALYs) after EVT for acute ischemic stroke because of large vessel occlusion in patients above age 80 years. Age-specific input parameters were obtained from the most recent/comprehensive literature. Good outcome was defined as a modified Rankin Scale score ≤2. Probabilistic, 1-way, and 2-way sensitivity analyses were performed for both healthy patients and patients with disability at baseline.

Results—

Base case calculation showed in functionally independent patients at baseline, intravenous thrombolysis (IVT) with tPA (tissue-type plasminogen activator) only to be the better strategy with 3.76 QALYs compared to 2.93 QALYs for patients undergoing EVT. The difference in outcome is 0.83 QALY (equivalent to 303 days of life in perfect health). For patients with baseline disability, IVT only yields a utility of 1.92 QALYs and EVT yields a utility of 1.65 QALYs. The difference is 0.27 QALYs (equivalent to 99 days of life in perfect health). Multiple sensitivity analyses showed that the effectiveness of EVT is significantly determined by the morbidity and mortality after both IVT and EVT strategies, respectively.

Conclusions—

Our study demonstrates the impact of relevant factors on the effectiveness of EVT in patients above 80 years of age. Morbidity and mortality after both IVT and EVT strategies significantly influence the outcomes in both healthy and disabled patients at baseline. Better identification of patients not benefiting from IVT would optimize the selective use of EVT thereby improving its effectiveness.
The 2018 Agreement to Prevent Unregulated High Seas Fisheries in the Central Arctic Ocean: A Critical Analysis
Authors: Schatz Valentin J. , Proelss Alexander , Liu Nengye
Published: March 2019

Following almost ten years of negotiations, the Agreement to Prevent Unregulated High Seas Fisheries in the Central Arctic Ocean (CAOF Agreement) was concluded on 3 October 2018 in Ilulissat, Greenland. The CAOF Agreement is the first regional fisheries agreement adopted prior to the initiation of fishing in a specific area, and it has already been lauded as a science-based measure and a manifestation of the precautionary approach by representatives of States and Non-Governmental Organizations. This article provides a critical analysis of the content of the CAOF Agreement. It gives an overview of the negotiations which led to the conclusion of the CAOF Agreement and discusses its spatial and substantive scope. Particular attention is paid to the extent that the CAOF Agreement adopts a precautionary approach to conservation and management of high seas fisheries, and to the issue of participation in this regional fisheries treaty.
Rooted Reciprocity
Authors: Wall Steven
Published: March 2019

Reciprocity is a moral value that concerns the accommodation of conflicting claims. This paper argues that the demands of reciprocity can come into conflict with the requirements of justice. This conflict is most readily apparent when reciprocity is viewed as a rooted notion, one that addresses the concerns and claims of actual people in less than ideal circumstances. Reciprocity is a value that figures prominently in the writings of those who call themselves political liberals. But political liberals, the paper also contends, have oversimplified the relationship between reciprocity and justice. Taking the rooted dimension of reciprocity seriously and thinking hard about the potential conflicts between reciprocity and justice moves us beyond the confines of the political liberal project and allows us to view reciprocity as a notion that illuminates the moral dimension of political compromise.
A bizarre new species of Lynchius (Amphibia, Anura, Strabomantidae)
from the Andes of Ecuador and first report of Lynchius parkeri in Ecuador
Authors: SÁNCHEZ-NIVICELA JUAN C. , URGILES VERONICA L. , NAVARRETE MARÍA JOSÉ , YÁNEZ-MUÑOZ MARIO H. , RON SANTIAGO
Published: March 2019

We describe a new species of Lynchius from the eastern montane forest of southern Ecuador. We also report the occurrence of L. parkeri in Ecuador, on paramos of Yacuri National Park, near the border with Peru. We used morphological and genetic evidence for the description of the new species and the new report of L. parkeri. Phylogenetic analyses were carried out using both maximum likelihood and Bayesian inference on DNA sequences for mitochondrial and nuclear genes. The phylogeny shows that L. simmonsi is sister to a clade composed of the remaining species of Lynchius and that the new species is sister to L. flavomaculatus. The new species has a prominent and heavily ossified head with noticeably spiculate cranial exostosis that easily distinguishes it from all its congeners. The dorsal region and limbs present several reduced subconical and rounded tubercles and pronounced dermal ridges on the dorsum. We also describe the osteology of the new species based on x-rays of the holotype. Only six species of Lynchius, two known to occur in Ecuador (L. flavomaculatus and L. simmonsi). The description of L. megacephalus sp. n. and new record of L. parkeri double the number of known Lynchius in Ecuador and suggest that the diversity of Ecuadorian and Peruvian Lynchius is still underestimated.
Distribution and status of Turdus thrushes in white-sand areas of eastern Colombia, with a new subspecies of T. leucomelas
Authors: STILES F. GARY , AVENDAÑO JORGE ENRIQUE
Published: March 2019

White-sand areas in the Colombian Amazon harbor many endemic and specialist species that are relatively little studied with respect to their ecology, distribution and zoogeographic affinities, for example Turdus thrushes. A recent expedition to the Serranía de Chiribiquete, a mountain range of Guianan origin in the Colombian Amazon, resulted in the discovery of an enigmatic Turdus thrush restricted to white-sand vegetation. Molecular phylogenetic analyses of the ND2 gene revealed that this population is genetically similar to T. leucomelas albiventer, from which it differs in its smaller size and darker, duller plumage. Therefore, we here describe this population as a new subspecies of T. leucomelas. Furthermore, our inspection of specimens of Turdus taxa from eastern Colombia revealed the existence of sympatry between T. ignobilis debilis and T. i. arthuri at two sites. Based on this evidence and previously documented genetic and phenotypic differences, we recognize T. arthuri as a distinct biological species. We analyze distributions and measurements of functional traits among four thrush taxa of eastern Colombia.
Variability and Predictability of North Atlantic Hurricane Frequency in a Large Ensemble of High-Resolution Atmospheric Simulations
Authors: Mei Wei , Kamae Youichi , Xie Shang-Ping , Yoshida Kohei
Published: March 2019

Variability of North Atlantic annual hurricane frequency during 1951–2010 is studied using a 100-member ensemble of climate simulations by a 60-km atmospheric general circulation model that is forced by observed sea surface temperatures (SSTs). The ensemble mean results well capture the interannual-to-decadal variability of hurricane frequency in best track data since 1970, and suggest that the current best track data might underestimate hurricane frequency prior to 1966 when satellite measurements were unavailable. A genesis potential index (GPI) averaged over the main development region (MDR) accounts for more than 80% of the SST-forced variations in hurricane frequency, with potential intensity and vertical wind shear being the dominant factors. In line with previous studies, the difference between MDR SST and tropical mean SST is a useful predictor; a 1°C increase in this SST difference produces 7.05 ± 1.39 more hurricanes. The hurricane frequency also exhibits strong internal variability that is systematically larger in the model than observations. The seasonal-mean environment is highly correlated among ensemble members and contributes to less than 10% of the ensemble spread in hurricane frequency. The strong internal variability is suggested to originate from weather to intraseasonal variability and nonlinearity. In practice, a 20-member ensemble is sufficient to capture the SST-forced variability.
Evapotranspiration Partitioning in CMIP5 Models: Uncertainties and Future Projections
Authors: Berg Alexis , Sheffield Justin
Published: March 2019

Evapotranspiration (ET) is a key process affecting terrestrial hydroclimate, as it modulates the land surface carbon, energy, and water budgets. Evapotranspiration mainly consists of the sum of three components: plant transpiration, soil evaporation, and canopy interception. Here we investigate how the partitioning of ET into these three main components is represented in CMIP5 model simulations of present and future climate. A large spread exists between models in the simulated mean present-day partitioning; even the ranking of the different components in the global mean differs between models. Differences in the simulation of the vegetation leaf area index appear to be an important cause of this spread. Although ET partitioning is not accurately known globally, existing global estimates suggest that CMIP5 models generally underestimate the relative contribution of transpiration. Differences in ET partitioning lead to differences in climate characteristics over land, such as land–atmosphere fluxes and near-surface air temperature. On the other hand, CMIP5 models simulate robust patterns of future changes in ET partitioning under global warming, notably a marked contrast between decreased transpiration and increased soil evaporation in the tropics, whereas transpiration and evaporation both increase at higher latitudes and both decrease in the dry subtropics. Idealized CMIP5 simulations from a subset of models show that the decrease in transpiration in the tropics largely reflects the stomatal closure effect of increased atmospheric CO2 on plants (despite increased vegetation from CO2 fertilization), whereas changes at higher latitudes are dominated by radiative CO2 effects, with warming and increased precipitation leading to vegetation increase and simultaneous (absolute) increases in all three ET components.
Deterministic Sea Waves Prediction Using Mixed Space–Time Wave Radar Data
Authors: Al-Ani M. , Christmas J. , Belmont M. R. , Duncan J. M. , Duncan J. , Ferrier B.
Published: March 2019

A number of maritime operations can benefit from a short-term deterministic sea wave prediction (DSWP). Conventional X-band radars have recently been shown to provide a low-cost convenient source of two-dimensional wave profile information for DSWP purposes. However, such rotating radars typically introduce temporal smearing into the data, which introduces errors when traditional Fourier transform–based wave prediction methods are used. The authors report on a new approach for DSWP that avoids such errors. Furthermore, it is not susceptible to the condition number problems that arise with any form of direct or indirect inversion-based approaches. Extensive numerical analyses are conducted to illustrate the effect of the mixed space–time nature of the data on DSWP and the efficiency of the proposed technique to handle it.
Work(ing) artefacts: Tools of the trade, totems or trophies?
Authors: Robinson Richard NS , Baum Tom
Published: March 2019

Do workplace artefacts have utility for their custodians beyond the workplace context? A new materiality perspective allowed the conversation to move beyond the parameters of the organisation and into the private spheres of both practicing and retired para-professionals. In this study of chefs, we discover the deliberate acquisition of occupational artefacts beyond their organisational utility. These artefacts betray a post-occupational identity deeply revelatory of materiality. We ask in what ways are these artefacts symbolic, or totemic? Findings provide fresh insights into how artefacts are mobilised as reverent ‘working’ objects, as totems and trophies for nostalgia. This facilitates reflections on how work was or ought to be, and so in turn who or ‘what I am’ or ‘who I was’. Theoretically, this enables us to extend the nexus of materiality and work and materiality and everyday life over both time and place.
An experimental study on the bending response of multi-layered fibre-metal-laminates
Authors: Kuhtz M , Buschner N , Henseler T , Hornig A , Klaerner M , Ullmann M , Jäger H , Kroll L , Kawalla R
Published: March 2019

The combination of thin light metal sheets with fibre-reinforced thermoplastic layers in multi-layered fibre-metal-laminates advantageously combines the properties of both material classes. In this way, components can be developed which have both significantly increased specific properties (strength and stiffness with respect to density) and high energy absorption capacity compared with conventional design with mono materials. However, the structural behaviour of crash structures is decisively determined by material behaviour of the thermoplastic and metal constituents as well as the interface properties between both constituents and the corresponding delamination behaviour. To evaluate the structural response of multi-layered fibre-metal-laminates under highly dynamic loading conditions, Charpy tests were performed, where the test parameters, light metal material configuration, support length and laminate thickness, were varied. Moreover, the metal sheet surfaces were pre-treated by embossing to achieve different surface topologies. The influence of the different test parameters on the specific energy absorption capacity was characterised by the analysis of force–displacement curves.
Contesting brandscapes in Hong Kong: Exploring youth activist experiences of the contemporary consumerist landscape
Authors: Lam-Knott Sonia
Published: March 2019

Since the 2000s, Hong Kong has become inundated with retail centres, such that the territory is now known as ‘Mall City’, a condition now problematised by youth activists in the city. This article is interested in why these youths take issue with this form of urban development. By tracing the emergence of the contemporary consumerist landscape from the colonial era to the present, it is shown that the current manifestation and characteristics of Hong Kong’s brandscapes are the product of unequal power dynamics between the Hong Kong Special Administrative Region (HKSAR) government, estate developers and the Hong Kong citizenry in shaping the city. By bringing youth activist voices to the forefront through the use of ethnographic data, the discussion then examines youth activist accounts detailing the experiential dimensions of living in this consumerist landscape, noting the feelings of alienation and exploitation circulating within the vernacular domains of Hong Kong society. The article concludes by reviewing the different ways these youths have attempted to reconfigure their relationship with this brandscape, and thus challenge the control the HKSAR government and estate developers have over Hong Kong urban space.
The Intimate Partner Violence Stigma Scale: Initial Development and Validation
Authors: Crowe Allison , Overstreet Nicole M. , Murray Christine E.
Published: March 2019

The stigma associated with intimate partner violence (IPV) is a major challenge facing those in abusive and violent intimate relationships. This study explored the initial development and validation of the Intimate Partner Violence Stigma Scale, designed to measure stigma related to IPV. An exploratory factor analysis revealed four subscales including internalized stigma, anticipated stigma, perpetrator stigma, and isolation. The scale demonstrates evidence for clinical and research purposes to assess experiences of stigma related to IPV among survivors.
Closing the Gender Pay Gap: New Approaches to an Old Problem
Authors: Stanberry Kurt
Published: March 2019

This article addresses new approaches to address a long-standing employment compensation problem—the gender pay gap. Existing approaches, including the Equal Pay Act and Title VII, are more than 50 years old, and have only been marginally successful in resolving this problem. A pay gap based on gender remains a problem today. New approaches include the potential passage of the Paycheck Fairness Act at the federal level and a variety of laws at the state level. Some states have passed pay equity laws that are more successful than the federal law due to the use of the comparable work concept. Additionally, some states have passed laws regulating the asking of salary history questions, as well as the use of non-compete and no-poaching agreements, all of which have a chilling effect on pay equity. The result of the combination of these actions is a probable reduction of the gender pay gap, although eliminating it remains a distant goal.
Predicting Teacher Effectiveness Based on Various Preservice Factors: Implications for Higher Education and the Evaluation of Teacher Preparation
Authors: McConnell John R. , Bruster Benita G. , Smith Vicky B.
Published: March 2019

The purpose of this study was to investigate a set of teacher-level factors that educator preparation providers (EPPs) may be examining to anticipate how effective teachers might be in the classroom. An ordinal logistic regression was performed to determine impact on teacher effectiveness, given five predictor variables: level (undergraduate vs. graduate), age, GPA, ACT, and Praxis II scores. The findings demonstrated that only level made a significant individual contribution to prediction, suggesting that undergraduate students were less likely to have higher teacher effectiveness scores than graduate students. The major implication for states may be to evaluate EPPs and their abilities to impact the quality of preservice teacher candidates separately based on whether they serve primarily undergraduate or graduate student populations.
Stroke Center Certification Is Associated With Improved Guideline Concordance
Authors: Jasne Adam S. , Sucharew Heidi , Alwell Kathleen , Moomaw Charles J. , Flaherty Matthew L. , Adeoye Opeolu , Woo Daniel , Mackey Jason , Ferioli Simona , Martini Sharyl , de los Rios la Rosa Felipe , Kissela Brett M. , Kleindorfer Dawn
Published: March 2019

Measurement of quality of stroke care has become increasingly important, but data come mostly from programs in hospitals that choose to participate in certification programs, which may not be representative of the care provided in nonparticipating hospitals. The authors sought to determine differences in quality of care metric concordance for acute ischemic stroke among hospitals designated as a primary stroke center, comprehensive stroke center, and non-stroke center in a population-based epidemiologic study. Significant differences were found in both patient demographics and in concordance with guideline-based quality metrics. These differences may help inform quality improvement efforts across hospitals involved in certification as well as those that are not.
Outcomes of Evans Versus Hintermann Calcaneal Lengthening Osteotomy for Flexible Flatfoot
Authors: Ettinger Sarah , Mattinger Tim , Stukenborg-Colsman Christina , Yao Daiwei , Claassen Leif , Daniilidis Kiriakos , Plaass Christian
Published: March 2019

Background:

Evans (E) and Hintermann (H) lateral lengthening calcaneal osteotomies (LLCOTs) are commonly used to correct flexible flatfoot deformities. Both methods are well accepted and produce good clinical results. The aim of this study was to compare the postoperative outcomes of both osteotomies.

Methods:

We retrospectively examined 53 patients with flatfoot deformities, who received surgery between October 2008 and March 2014. Seventeen E-LLCOT and 36 H-LLCOT procedures were performed during this time period, with a mean follow-up of 67.7 ± 20.6 and 40 ± 12.9 months, respectively. Data were collected using clinical and radiological examination, as well as clinical scores (Foot and Ankle Outcome Score [FAOS], University of California at Los Angeles [UCLA] activity score, numerical rating scale [NRS], and the Short-Form 36-item Health Survey [SF-36]) during regular follow-up.

Results:

For both groups of patients, the FAOS score, pain-NRS, and SF-36 improved significantly following surgery ( P < .05). The talus–second metatarsal angle, talonavicular coverage, and naviculocuneiform overlap showed significant correction ( P < .05). Postoperatively, radiographic degenerative changes were detected in the calcaneocuboid (CC) and subtalar joint in both groups of patients: 41% and 18% after E-LLCOT compared with 25% and 14% after H-LLCOT, although these changes did not have any clinical relevance ( P < .05). No secondary arthrodesis was necessary. There were no significant differences in the clinical or radiological outcome parameters when compared between the 2 groups.

Conclusion:

Both surgical techniques resulted in a significant improvement of clinical outcome scores and led to good radiological correction of flatfoot deformities. It appears that the CC joint develops less degenerative changes following the H-LLCOT procedure.

Level of Evidence:

Level III, comparative series.