bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation Analysis Between Information Exposure and Knowledge of National Health Insurance among The Community in Sungai Lebung Village
Authors: Ghita Apriani  , Ainy Asmaripa , Annisa Rahmawaty
Published: April 2023

Rural communities tend to be more hesitant to accept and adopt information. This behaviour affects the knowledge they have, especially knowledge related to JKN. This study aims to determine the relationship between information exposure and JKN knowledge in the Sungai Lebung Village community. This quantitative study a cross-sectional design and purposive sampling technique for a total sample size of 108 respondents. The multiple logistic regression of risk factors was the statistical analysis used in this study. The univariate test results showed that 60 respondents (55.6%) had low JKN knowledge. Multivariate analysis showed that exposure to JKN information was associated with JKN knowledge after being controlled by confounding variables such as gender, education, occupation, and health worker support. People exposed to JKN information sourced by BPJSK have a 3.5 times chance of having high knowledge related to JKN. It can be concluded that socialization concerning JKN using information media sourced by BPJSK needs to be improved by considering gender, education, employment and health worker support.
Unforeseen Digital Eye Strain of Children : A Review
Authors: Irawaty Dian Kristiani , Oktaviani Maya
Published: April 2023

People of all ages are using mobile devices more frequently, and more children are reportedly using digital media as well, which raises the risk of Digital Eye Strain (DES). There have been few studies on how often DES affects children particularly post-pandemic. The purpose of this study is to review published literature concerning DES, including its pathogenesis and therapy options. A literature search was performed based on PubMed, EMBASE and Scopus databases published from 2003 to 2023 using the broad search term “digital eye strain”, “ocular asthenopia secondary to digital gadgets”, “computer vision syndrome”, “eye strain post-computer or mobile use”, “visual weariness”, and “children" in all fields. Of the 163 articles retrieved, 107 were retained for inclusion in this review. The result reveals that there is an urgent need to inform parents, caregivers, and youth about setting screen time limits and applying ergonomic practices due to the recent surge in digital electronic gadget usage among kids and young adults.
Implementation of markov chain in predicting regeneration agricultural in Pasuruan district
Authors: Wahid Abdul , Pusakaningwati Ayik , Masud M. Imron
Published: April 2023

The Industrial Era 5.0 has made many positive and negative changes in various sectors, one of the negative impacts is the agricultural sector related to the lower portion of young farmers so that it must be a serious concern for the government in future agricultural development programs, especially in agricultural base areas such as in Pasuruan Regency. This situation encourages the importance of finding solutions to realize the regeneration of farmers. This study aims to analyze the transformation between generations of agricultural workers in Pasuruan Regency through the Marcov Chain model approach. The final result of this study is the analysis of transformations between generations of agricultural workers in Pasuruan Regency so that it can be used as a basis for formulating future policies for better future generations of agriculture.
Inactivation of p53 provides a competitive advantage to del(5q) myelodysplastic syndrome hematopoietic stem cells during inflammation
Authors: Muto Tomoya , Walker Callum S. , Agarwal Puneet , Vick Eric , Sampson Avery , Choi Kwangmin , Niederkorn Madeline , Ishikawa Chiharu , Hueneman Kathleen , Varney Melinda , Starczynowski Daniel T.
Published: April 2023

Inflammation is associated with the pathogenesis of myelodysplastic syndromes (MDS) and emerging evidence suggests that MDS hematopoietic stem and progenitor cells (HSPC) exhibit an altered response to inflammation. Deletion of chromosome 5 (del(5q)) is the most common chromosomal abnormality in MDS. Although this MDS subtype contains several haploinsufficient genes that impact innate immune signaling, the effects of inflammation on del(5q) MDS HSPC remains undefined. Utilizing a model of del(5q)-like MDS, inhibiting the IRAK1/4-TRAF6 axis improved cytopenias, suggesting that activation of innate immune pathways contributes to certain clinical features underlying the pathogenesis of low-risk MDS. However, low-grade inflammation in the del(5q)-like MDS model did not contribute to more severe disease but instead impaired the del(5q)-like HSPC as indicated by their diminished numbers, premature attrition and increased p53 expression. Del(5q)-like HSPC exposed to inflammation became less quiescent, but without affecting cell viability. Unexpectedly, the reduced cellular quiescence of del(5q) HSPC exposed to inflammation was restored by p53 deletion. These findings uncovered that inflammation confers a competitive advantage of functionally defective del(5q) HSPC upon loss of p53. Since TP53 mutations are enriched in del(5q) AML following an MDS diagnosis, increased p53 activation in del(5q) MDS HSPC due to inflammation may create a selective pressure for genetic inactivation of p53 or expansion of a pre-existing TP53-mutant clone.
Asciminib in chronic myeloid leukemia: a STAMP for expedited delivery?
Authors: Padala Sandeep , Cortes Jorge
Published: April 2023

Asciminib is a novel tyrosine kinase inhibitor (TKI) that specifically targets the myristoyl pocket. It has increased selectivity and potent activity against BCR-ABL1 and the mutants that most frequently prevent the activity of the ATPbinding competitive inhibitors. Results for clinical trials in patients with chronic myeloid leukemia that have received two or more TKI (randomized against bosutinib) or who have a T315I mutation (single arm study) have shown high levels of activity and a favorable toxicity profile. Its approval has offered new options for patients with these disease features. There are, however, a number of unanswered questions that remain to be defined, including the optimal dose, understanding the mechanisms of resistance, and, importantly, how it compares to ponatinib in these patient populations for whom we now have these two options available. Ultimately, a randomized trial is needed to answer questions to which we currently offer speculative informed guesses. The novelty of its mechanism of action and the exciting early data offer the potential for asciminib to address some of the remaining needs in the management of patients with chronic myeloid leukemia, including second-line therapy after resistance to a front-line second-generation TKI and improving successful treatment-free remission. Multiple studies are ongoing in these areas, and one can only hope that the desired randomized trial comparing asciminib to ponatinib will be conducted soon.
Obstrucción en la unión ureterovesical en una hembra canina: a propósito de un caso clínico
Authors: Pilco Calderón Stephanie Lizbeth , Castillo Hidalgo Edy Paul
Published: April 2023

Introducción. Se describe el caso de un paciente canino, raza caniche, no esterilizada, de 4 meses de edad, que padece de incontinencia urinaria desde temprana edad. Se efectuaron varios exámenes clínicos para llegar al diagnóstico, entre ellos: química sanguínea, hemograma, elemental y microscópico de orina, rayos x, ecografía, dando como diagnóstico presuntivo uréter ectópico. Con la anamnesis y los resultados de los exámenes, se procedió a realizar una laparotomía exploratoria, en la que se encontraron adherencias en la unión ureterovesical derecha, descartando uréter ectópico. La resolución quirúrgica se basó en la liberación del uréter y posteriormente se aplicó la técnica de colposuspensión descrita por Holt en 1990, permitiendo así un mejor posicionamiento de la vejiga y uréteres a nivel abdominal. Objetivo. Describir los hallazgos, resolución y tratamiento empleado en el caso clínico. ​Metodología. En el presente reporte de caso se detalla los exámenes realizados y la técnica quirúrgica empleada para corregir la obstrucción en la unión ureterovesical de la paciente. Resultados. Tras la resolución quirúrgica, la paciente evoluciono de manera favorable, por lo que se determina que la liberación del uréter y la colposuspensión fueron efectivas, lo cual se corrobora con la ausencia de anormalidades en los exámenes de control. Conclusión. Tomando a consideración el riesgo de desarrollar una enfermedad renal a corto o largo plazo en la paciente, el manejo de la adherencia en la unión ureterovesical y la aplicación de la técnica de colposuspensión descrita por Holt fue propicio para la edad y etapa reproductiva de la paciente, ya que permitió que el equipo médico realice un manejo oportuno del caso clínico descrito.
Análisis de prototipos del sistema Eco Cooler como estrategia de diseño pasivo bioclimático en clima tropical, en la ciudad de Tena - Ecuador
Authors: Aguilera Jiménez José Luis , Avila Calle Marco , Moscoso García Pedro
Published: April 2023

El consumo energético eléctrico que tienen las edificaciones al usar aires acondicionados o sistemas de refrigeración representa al 60% de energía consumida en edificios. El sistema de refrigeración y ventilación de un ambiente juega un papel importante en el confort del usuario, pero no necesariamente debe ser consumidor de energía, esto se puede solventar con alternativas de envolventes pasivas, se analiza el sistema ECO COOLER como estrategia de diseño pasivo para refrigerar ambientes habitables disminuyendo la cantidad de consumo energético a través de celosías en fachadas ubicadas en climas tropicales. Se realiza una revisión bibliográfica del comportamiento térmico que tiene una vasija de barro, y se elabora una maqueta conceptual para hacer la medición de temperaturas con variables de fachada libre y envolvente con celosía de vasijas de barro, que son sometidas a una pistola de calor para demostrar la variación de temperatura. Este elemento tiene una peculiaridad en su material y composición, que es poroso y el proceso que sucede a su interior es enfriar por el efecto de refrigeración por evaporación, la porosidad de la vasija de barro hace que el agua filtre y se evapore, bajando la temperatura del agua restante. Los factores para el enfriamiento dependen de las condiciones ambientales, mientras más calor haga en el ambiente, la evaporación será más rápida, a este método se lo conoce como efecto de botijo. Se plantea un prototipo de vasija de barro con características de sudoración, almacenamiento y sistema de rebosadero para un auto llenado y se aplica el envolvente de celosía sobre una fachada, la estrategia pasiva ECO COOLER por vasijas de barro, cumple el propósito de enfriamiento de espacios sin necesidad del uso de energía eléctrica, disminuyendo el uso de electrodomésticos como es el aire acondicionado, un artefacto de mucha demanda energética hoy en día. Área de la ciencia: arquitectura.
ATAGI Targeted Review 2022: Vaccination for prevention of herpes zoster in Australia
Authors: Huang Yuanfei Anny , Li-Kim-Moy Jean , Jayasinghe Sanjay , Chiu Clayton , Macartney Kristine , Liu Bette , Burns Penelope , Giles Michelle , Crawford Nigel
Published: April 2023

In November 2016, herpes zoster (HZ) vaccination for older adults, using the live-attenuated zoster vaccine (Zostavax; ZVL) was added to the Australian National Immunisation Program (NIP) with the aim of reducing morbidity from HZ and its complications, particularly for people at increased risk. Prior to the program, there were on average 5.6 cases of HZ per 1,000 persons annually in Australia, with highest risk of disease in older and in immunocompromised people. The burden of complications of HZ, such as post-herpetic neuralgia (PHN), was also highest in older and immunocompromised groups. No formal comprehensive program evaluation has been undertaken since program commencement. This review examined published literature and available vaccine administration data to summarise the evidence and considerations underpinning current use of HZ vaccines and potential future program directions in Australia. There have been modest reductions in the incidence of HZ and its complications since program introduction. However, five years into the program, challenges remain, including suboptimal vaccine coverage and significant safety concerns arising from inadvertent use of ZVL in immunocompromised people, who are contraindicated to receive this vaccine. This reduces opportunities to offset the burden of HZ-related disease. The recombinant subunit zoster vaccine (Shingrix; RZV), first registered in Australia in 2018, became available on the Australian market in June 2021. This vaccine has higher efficacy than ZVL and, as a non-live vaccine, can be used in both immunocompetent and immunocompromised people. RZV has potential to address the unmet needs of at-risk population groups. However, it has not yet demonstrated cost-effectiveness for inclusion as a funded vaccine under the NIP. The Australian HZ vaccination program has had limited effectiveness in meeting its aim in highest risk groups. Future options and challenges anticipated in using vaccination to reduce the burden of HZ and its complications are discussed in this review.
Cohorting children in a childcare setting: a strategy to reduce SARS-CoV-2 Delta transmission, August-September 2021
Authors: Lisson Yasmin , Marmor Alexandra , Gomez Algreg , Hall Robyn , Parry Amy Elizabeth , Wright Rose , Lal Aparna
Published: April 2023

Abstract Background Childcare centres can be high-risk settings for SARS-CoV-2 transmission due to age, vaccination status, and infection control challenges. We describe the epidemiology and clinical characteristics of a childcare SARS-CoV-2 Delta outbreak. When the outbreak occurred, little was known about the transmission dynamics of SARS-CoV-2 ancestral and Delta strains among children. Vaccinations for coronavirus disease 2019 (COVID-19) were not mandatory for childcare staff, and children (< 12 years) were ineligible. Methods A retrospective cohort design of childcare attendees was used to investigate age-cohorts exposure and transmission of SARS-CoV-2. We defined a case as a person who tested positive to SARS-CoV-2; we defined a close contact as a person who attended the childcare during 16–20 August 2021. Childcare centre exposures were defined by three cohorts: younger children (0–< 2.5 years) with designated staff; older children (2.5–5 years) with designated staff; and a staff-only group that moved between both age cohorts. We calculated the number and proportion of SARS‐CoV‐2 Delta infections, symptom profile and severity in children and adults, secondary attack rates, and relative risks (RR) with 95% confidence intervals (CIs) to compare age-cohort exposures and SARS-CoV-2 infection. Results There were 38 outbreak cases that tested positive to SARS-CoV-2 Delta infection, comprising one primary case, 11 childcare attendees and 26 household members. Child attendees were in two non-interacting groups, 0–< 2.5 years and 2.5–5 years, with designated staff, separate rooms, and independent ventilation. The greatest risk of infection to childcare attendees was in the < 2.5 years age cohort which had a secondary attack rate of 41% and were five times more likely to be infected with SARS-CoV-2 (RR = 5.73; 95% CI: 1.37–23.86; p ≤ 0.01). No identified transmission (n = 0/21) occurred in the ≥ 2.5 years age cohort. Conclusion Young children play an important role in SARS-CoV-2 Delta transmission to their peers and staff in childcare settings and to household members. Cohorting may be effective at limiting the propagation of SARS-CoV-2 in childcare settings. These findings highlight a need for multi-layered mitigation strategies and implementation support to manage respiratory infection control challenges at childcares. If prevention measures are not in place, this may facilitate ongoing transmission in these settings and into the broader community.
Combatting Human Trafficking in Saudi Arabia
Authors: Al Agha Samah
Published: April 2023

Background: Trafficking in human beings is a crime that violates human rights. Recent years have witnessed an increase in human trafficking for the purpose of commercial sex exploitation, forced labour, and beggary, to name but a few. Globalisation and advanced technology have been exploited by perpetrators of trafficking in human beings. This phenomenon is becoming more difficult to discover and investigate due to its nature and complexity. The purpose of this research is to explore the legal response to the crime of trafficking in human beings in the Kingdom of Saudi Arabia.
Methods: This research uses a combination of primary and secondary resources such as the assigned laws, caselaw, academic books, journal articles, and reliable websites.
Results and Conclusions: After working out that this crime falls within the scope of Ta’zer Crimes but not Hudud and Qisas crimes, the paper examines the efficiency of the Saudi Anti-Trafficking in Persons Law 2009 from two aspects, the effectiveness of penalties imposed on the human traffickers and the feasibility of protective measures provided in the law for safeguarding the trafficked person (victims). Finally, the study concludes with some findings and recommendations.
Lise Öğrencilerinin Yaşlı Ayrımcılığına İlişkin Tutumlarının Belirlenmesi
Authors: Ercan Fatümatü Zehra , Ercan Merve , Koçak Orhan
Published: April 2023

Bu araştırmanın amacı; lise öğrencilerinin yaşlı ayrımcılığına ilişkin tutumlarını anlamaktır. Betimleyici tipteki bu araştırmanın örneklemini 291lise öğrencisi oluşturmaktadır. Veri toplama araçları olarak Yaşlı Ayrımcılığı Tutum Ölçeği (YATÖ) ve Öğrenci Bilgi Formu kullanılmıştır. Veriler SPSS for Mac 21(Statistical Package for Social Sciences) programı ile analiz edilmiştir. analizde; ortalama, standart sapma, minimum, maksimum değerler, yüzdelik sayılar, Mann-Whitney U, Kruskal-Wallis, Anova testi yapılmıştır. Araştırmada elde edilen bulgulara göre; lise öğrencilerinin yaşlı ayrımcılığına yönelik genellikle olumlu tutum sergilediği ve yaşlı ayrımcılığı tutum ölçeği puanları ile öğrencilerin cinsiyet, doğum yeri, en fazla yaşanan yer, anne ve babanın eğitim durumları, büyükanne/büyükbabanın yaşadığı yer değişkenleri arasında anlamlı farklılıkların olduğu tespit edilmiştir (p0.05). Boylamsal bir olgu olarak yaşlığa dönük algının anlaşılmasında ergenlerin tutumları ve bu tutumları belirleyen etmenler önemlidir. Kentleşmeyi modern ve geleneksel unsurlarla birlikte deneyimleyen Malatya kentinde eğitim gören lise öğrencilerinin yaşlı ayrımcılığına yönelik tutumlarının önemli bir temsil olduğu düşünülmektedir.
SOSYAL ÇALIŞMACILARIN BİLİRKİŞİLİK UYGULAMALARININ HÂKİMLERİN BAKIŞ AÇISIYLA DEĞERLENDİRİLMESİ
Authors: Kesen Nur Feyzal , Bilgin Özkan
Published: April 2023

Adli sosyal çalışmacılar, yargı içerisinde soruşturma süreçlerinde ve mahkemelerde bilirkişi olarak görev yapmaktadır ve uzmanlık bilgisi ile yaptığı değerlendirmelerle yargı kararlarına etki etmektedir. Bu araştırmanın temel amacı adli sosyal çalışmacıların bilirkişilik görevlerini hâkimlerin bakış açısıyla incelemektir. Araştırmaya adli yargıda görev yapan 60 hâkim katılmıştır. Araştırma verilerinin toplanmasında araştırmacılar tarafından hazırlanan ve 13 sorudan oluşan soru formu yüz yüze yapılan görüşmelerle doldurularak yanıtlar aranmaya çalışılmıştır. Tarama modelli bir araştırma şeklinde tasarlanan araştırmada, elde edilen yanıtlar SPSS 21 paket programı kullanılarak analiz edilmiş ve veriler frekans dağılımları şeklinde analiz edilmiştir. Araştırma sonucuna göre; adli sosyal çalışmacılardan mahkemelerde sözlü değerlendirme yaparak ve rapor düzenleyerek bilirkişilik yaptığı, bilirkişi olarak düzenledikleri raporların mahkeme kararlarına önemli düzeyde etki ettiği, korunmaya ihtiyacı olan çocuk, suça sürüklenen çocuk, velayet düzenlemesi, kişisel ilişki kurulması, aile hukukundan doğan yükümlülüğün ihlali, evlat edinme ve vasi tayini konularında bilirkişi olarak görüş ve değerlendirmelerine başvurulduğu ve adli sosyal çalışmacıların bilirkişilik görevlerini yerine getirirken çeşitli hususlarda yetersiz kaldıkları bulunmuştur. Elde edilen bulgular doğrultusunda sorunun çözümüne yönelik bazı öneriler sunulmuştur.
Attachment dimensions and problem behaviors in middle-childhood children of women receiving service from a psychiatry clinic
Authors: Taşkıran Tepe Hacer , Özmete Emine
Published: April 2023

This study aimed to examine the differences between middle-childhood children of mothers receiving and not receiving mental health services in terms of attachment dimensions and problem behaviors, and the relationship of problem behaviors in middle-childhood children with some socio-demographic variables.
Using quantitative research method, this study had two sample groups: the study and comparison groups. Additionally, it involved a total of 127 mothers and 127 children in the 9-14 age group, including 62 mothers and their children in the study group (receiving mental health services) and 65 mothers and their children in the comparison group (not receiving mental health services). For data collection, the following scales were applied to both groups. The data collecting process consisted of the Personal Information Form, the Experiences in Close Relationships Scale II – Middle-Childhood, and the Strengths and Difficulties Questionnaire (AB 4-16).
The results showed that the study group children tended to have insecure attachment and problematic behaviors more than the comparison group children. In addition to mother’s need for mental health services, mother’s educational level, child’s birth after an unplanned pregnancy, and separation from one or both parents for a period were also considered as important factors affecting problem behaviors in children.
This study revealed the preventable factors in the development of problem behaviors in children. These results contribute to the practices of mental health professionals and the role of child welfare systems in developing protective-preventive services.
Mevsimlik Tarım İşçiliğinin Görülmeyen ve Duyulmayan Kesimi: Yaşlı İşçiler
Authors: Özkan Gizem , Çağlar Türken
Published: April 2023

Bu araştırmanın amacı mevsimlik tarım işçisi yaşlı bireylerin yaşam ve çalışma deneyimlerini anlamak, yaşadıkları sorunlara dikkat çekmek ve sosyal hizmet gereksinimlerini değerlendirmektir. Nitel bir araştırma olan bu çalışmada fenomenolojik desen kullanılmıştır. Veriler, araştırmacılar tarafından hazırlanan “Kişisel Bilgi Formu” ve “Yarı Yapılandırılmış Görüşme Formu” ile toplanmıştır. Araştırma öznelerine kartopu örnekleme ile ulaşılmıştır. Bu kapsamda Sivas iline mevsimlik tarım işinde çalışmak amacıyla gelen 60 yaş ve üzeri 11 kadın 19 erkek toplam 30 bireyle görüşme yapılmıştır. Görüşmelerden elde edilen veriler betimsel analiz yaklaşımıyla analiz edilmiştir. Mevsimlik tarım işçisi yaşlı bireylerin sağlık, bakım ve barınma, çalışma koşulları, ekonomik, sosyal güvenlik, beslenme, ulaşım, sosyal dışlanma, sosyal hizmetler ve politika konularında pek çok sorun deneyimledikleri sonucuna ulaşılmıştır. Bunda mevsimlik tarım işçilerinin yaşadıkları sorunları gidermeye ve bu bağlamda gereksinimlerini karşılamaya yönelik sosyal politika, hizmet ve uygulamaların yetersiz olmasının etkisinin büyük olduğu düşünülmektedir. Mevsimlik tarım işçisi yaşlı bireylerin ihtiyaçlarını gidermek ve yaşam koşullarını iyileştirmek için hak temelli, sistematik, bütüncül, kapsayıcı, yaşlı merkezli ve yaşlıların yüksek yararını önceleyen politikaların üretilmesi, hizmetlerin sunulması ve müdahalelerin gerçekleştirilmesi gerekmektedir.
Yaşlı Nüfusun Geleceği ve Sağlık Hizmetleri ile İlişkilendirilmesi: Dünya Bankası Gelir Grupları Üzerine Bir Araştırma
Authors: Şenol Osman , Cansever İbrahim Hüseyin
Published: April 2023

Yaşlılık önümüzdeki on yıllarda tüm dünya ülkelerinin önemli bir sorunu olarak görülmektedir. Mevcut yaşlı nüfusun gelecekte birçok sebebe bağlı olarak önemli derecede artış göstereceği yapılan tahminlerde görülmektedir. Araştırmanın amacı, yaşlı nüfusun gelecekteki durumunun tahmin edilmesi ve sağlık hizmetleri ile ilişkisinin ortaya konulmasıdır. Amaca yönelik olarak, ülke gruplarının yaşlı nüfus oranlarının geleceğe yönelik tahminleme yapılmasında ARIMA modeli uygulanmıştır. Araştırmanın verileri, Dünya Bankası’nın ülkeleri gelir düzeylerine göre gruplandırması dikkate alınarak; düşük, alt-orta, üst-orta ve yüksek gelirli ülkelerin toplam nüfusları içerisinde 65 ve üstü nüfus oranlarından oluşmaktadır. Veriler 1960-2019 dönemlerini kapsamakta, verileri analiz etmek için Eviews 9.0 ile Stata 15.0 paket programları kullanılmıştır. Araştırmada 65 yaş üstü nüfus oranının 2030 yılında; düşük ve alt-orta gelirli ülkelerde %1,28’lik bir artış göstererek %3.3218 seviyesine yükseleceği, üst-orta gelir grubundaki ülkelerde %34,88’lik bir artış göstererek %10,8670’e yükseleceği ve yüksek gelir grubu ülkelerde ise %13,77’lik bir atış göstererek %21,1061 seviyesine yükseleceği öngörülmüştür. Artan yaşlı nüfusun gelecekte önemli derecede sağlık harcamalarını da artıracağı öngörülmektedir. Nitekim araştırmada 2000-2019 yılı verilerinde düşük ve alt-orta, üst-orta ve yüksek gelir grubundaki ülkelerin Gayri Safi Yurtiçi Hasıla (GSYH) ve GSYH’den sağlığa ayrılan ortalama payın önemli derecede artış gösterdiği görülmüştür. Geleceğe yönelik olarak yaşlılara sunulacak sağlık hizmetlerinde; multidisipliner bir yaklaşım sergilenmesi, merkezi hükümetlerin yerel yönetim birimlerini de içerecek şekilde planlamalar yapması ve uygulama alanında birlikte hareket etmesi, yaşlanmaya karşı oluşturulacak politikalarda kamu ile özel sektörün birlikte hareket etmesi ve geleceğe yönelik net planlama çalışmaları yapılması gibi öneriler sunulmuştur.
No evidence from long-term analysis of yellowfin tuna condition that drifting fish aggregating devices act as ecological traps
Authors: Dupaix A , Dagorn L , Duparc A , Guillou A , Deneubourg JL , Capello M
Published: April 2023

Human-induced habitat modifications can severely impact the biology and behavior of wild species. Drifting fish aggregating devices (DFADs), used by industrial purse-seine tropical tuna fisheries, significantly increased the number of floating objects found in the open ocean, with which tropical tuna associate. This habitat change has raised concerns over the risk of modifying the behavior and altering the biology of tuna and other associated species (the so-called ecological trap hypothesis). Relying on a time-series from 1987-2019 of more than 25000 length-weight samples collected in the western Indian Ocean, we reject the hypothesis that the body condition (Le Cren’s relative condition factor, Kn) of yellowfin tuna Thunnus albacares decreased concurrently with the increased number of DFADs. This result suggests the absence of negative long-term impacts of DFADs on the condition of tuna. As other factors may have counteracted possible negative effects of DFADs, we recommend long-term monitoring of the habitat along with biological and behavioral parameters of tunas to detect any critical change.
PEMANFAATAN MEDIA SOSIAL INSTAGRAM DALAM PEMBELAJARAN BAHASA INGGRIS PADA SISWA ENGLISH CLUB DI SMPN 163 JAKARTA
Authors: Saragih Mike Wijaya , Br. Sinulingga Febrimarini , Sitohang Susanne A.H. , Thesalonika Alvina  , Hia Adiranto
Published: April 2023

Tulisan ini bertujuan untuk menunjukkan hasil kegiatan Pengabdian kepada Masyarakat (PkM) Fakultas Sastra dan Bahasa UKI yang berfokus pada pemanfaatan media sosial Instagram dalam pembelajaran bahasa Inggris pada siswa English Club SMPN 163, Jakarta, pada periode Agustus s.d. November 2022. Instagram digunakan sebagai media untuk mengevaluasi pemahaman siswa/I terhadap materi pembelajaran yang diberikan pengajar setiap minggunya. Bentuk penugasan yang diberikan beragam, mulai dari membuat poster, video, esai singkat, bahan presentasi, dan kartu ucapan, yang disesuaikan dengan tema-tema mingguan, dan dilakukan baik secara mandiri maupun kelompok. Dari evaluasi pembelajaran yang disebar melalui Google form, terdapat 52 responden yang terdiri dari 33 responden perempuan dan 19 responden laki-laki. Hasil survei menunjukkan lebih dari 90% responden merasakan manfaat penggunaan Instagram dalam proses pembelajaran Bahasa Inggris, baik dalam hal meningkatkan keterampilan teknis (hard skill) maupun keterampilan non teknis (soft skill). Keterampilan teknis yang diperoleh berkaitan dengan keterampilan bahasa Inggris baik lisan maupun tulisan dan keterampilan dalam membuat dan mengedit poster dan video, sedangkan keterampilan non teknis yang diperoleh berkaitan dengan kreativitas dan kemampuan untuk bekerja sama di dalam tim. Hasil evaluasi juga menunjukkan lebih dari 80% peserta English Club merekomendasikan dilanjutkannya pemanfaatan Instagram dalam proses pembelajaran bahasa Inggris mendatang.   

Kata Kunci: English Club; Instagram; keterampilan teknis dan non teknis
СИСТЕМА СУБ’ЄКТІВ, ЩО ЗДІЙСНЮЮТЬ АДМІНІСТРАТИВНО-ПРАВОВЕ ЗАБЕЗПЕЧЕННЯ НАСЕЛЕННЯ КУЛЬТУРНИМИ ПОСЛУГАМИ
Authors: Аксютіна А. В. , Чвалюк А. М.
Published: April 2023

У статті проаналізовано повноваження суб’єктів адміністративно-правового забезпечення населення культурними послугами та здійснено їх систематизацію. Встановлено, що система суб’єктів адміністративно-правового забезпечення населення культурними послугами представлена декількома рівнями організованих установ та осіб, кожна з яких має в ній свій статус, перелік функцій і місце. Визначено, що основу державної політики у сфері соціально-культурного будівництва формує Верховна Рада України, а головним органом у системі центральних органів виконавчої влади, що забезпечує формування та реалізує державну політику у сферах культури є Міністерство культури та інформаційної політики України. Зазначене Міністерство здійснює свої функції у сфері культури як самостійно, так і через підпорядковані або координовані ним центральні органи виконавчої влади зі спеціальним статусом (різні державні служби, комітети агентства та ради). На регіональному та місцевому рівнях суб’єктами центральної ланки адміністративно-правового забезпечення населення культурними послугами є виборні органи (ради) територіальних громад, в особі комітетів культури, або виконавчі органи (місцеві державні адміністрації), в особі відділів (секторів) культури. У складі місцевих державних адміністрацій діють відповідні департаменти або управління культури. Зроблено висновок, що рівень нормативно-правового забезпечення діяльності, аналізованих у статті суб’єктів адміністративно-правового забезпечення населення культурними послугами, у цілому задовільний, однак потребує вдосконалення. Авторами піддано критиці деякі формулювання Закону України «Про культуру», у якому в рамках окремого розділу запропоновано закріпити функції та повноваження вищих органів державної влади у сфері культури. Сформульовані пропозиції, спрямовані на спрощення процесу адміністративно-правого регулювання культурної сфери й уточнення адміністративно-правового статусу вищих органів державної влади.
МІЖНАРОДНІ СТАНДАРТИ ПРАВОВОГО РЕГУЛЮВАННЯ ОХОРОНИ ПРАЦІ НЕПОВНОЛІТНІХ
Authors: Мелех Л. В.
Published: April 2023

У статті розглянуто аспекти правового регулювання праці неповнолітніх відповідно до чинного законодавства зарубіжних країн. Проведено аналіз окремих питань охорони праці неповнолітніх як особливого суб’єкта трудового права, а також пов’язаних із цим проблем. Акцентовано увагу на деяких прогалинах у трудовому законодавстві України. Запропоновано усунути правові колізії та вдосконалити правові норми з питань захисту праці неповнолітніх. Внесено пропозиції щодо перегляду на законодавчому рівні робочого часу для неповнолітніх, їхніх умов праці, норм відпусток і т. ін., з метою збереження здоров’я і створення умов для повноцінного розвитку підлітків. Припущено подальше опрацювання питання охорони праці неповнолітніх у сучасних умовах на рівні подальших ґрунтовних наукових досліджень. Важливим є те, що розширюються гарантії прав неповнолітніх шляхом ухвалення нових національних нормативно-правових актів, удосконалення чинних і ратифікації відповідних міжнародних актів. У міжнародному праві питання праці дітей до 14 років врегульоване завдяки низці правових актів, а саме: Загальній декларації прав людини, Конвенції Організації Об’єднаних Націй про права дитини, Конвенції про мінімальний вік приймання дітей на роботу у промисловості № 5. Однак останні містять норми щодо праці неповнолітніх на промислових підприємствах, а в нашій державі це заборонено. В Україні праця осіб до 14 років спостерігається у творчій сфері (участь у різних телепередачах, зйомка в рекламі, танці, спів тощо), проте регулювання такої праці не передбачено національним законодавством. Творча діяльність визначена в Конвенції про вік приймання дітей на непромислові роботи № 33, яку Україна не ратифікувала. Доцільно було б внести зміни до чинного КЗпП України й ухвалити нормативно-правові акти, що регулювали би працю неповнолітніх осіб віком до 14 років у творчій сфері, а саме: слід визначити порядок працевлаштування, працю та забезпечення реалізації прав та свобод таких осіб.
ОСОБЛИВОСТІ ПРОВЕДЕННЯ ДОПИТІВ У РОЗСЛІДУВАННІ ЗЛОЧИНІВ, УЧИНЕНИХ ЗЛОЧИННИМИ СПІЛЬНОТАМИ
Authors: Бондар В. С.
Published: April 2023

У статті висвітлено актуальні теоретичні й практичні процесуальні, організаційні та методичні проблеми проведення допитів у розслідуванні злочинів, учинених злочинними спільнотами. Визначено специфіку проведення допитів у розслідуванні злочинів, учинених злочинними спільнотами. Зауважено, що вибір тактичних прийомів повинен визначатися на підставі оцінки вихідної інформації, наявної в розпорядженні уповноваженого оперативного підрозділу на початку реалізації про: предмет злочинного посягання; спосіб вчинення злочину; встановлені в процесі оперативно-розшукового документування факти кримінально-протиправної діяльності розроблюваних осіб; наявність співучасників тощо. Доведено, що на вибір тактики допиту при розслідуванні злочинів, учинених злочинними спільнотами, впливають певні закономірності, які мають прояв під час проведення допитів, котрі об’єднано в три групи: - закономірності, пов’язані з особливостями процесу доказування при допитах підозрюваних у злочинах, вчинених злочинними спільнотами; - закономірності, які впливають на тактичні особливості, що враховуються при допитах під час кримінального провадження; - закономірності, які мають прояв в особливостях поведінки всіх учасників злочину під час досудового слідства, що визначають тактику допиту під час розслідування злочинів, вчинених злочинними спільнотами. Сформульовано рекомендації щодо збирання інформації про членів злочинної спільноти на підготовчому етапі допиту та найбільш раціонального застосування тактичних прийомів при проведенні даної слідчої (розшукової) дії за участю членів злочинної спільноти.
УРАХУВАННЯ ПРАКТИКИ ЄВРОПЕЙСЬКОГО СУДУ З ПРАВ ЛЮДИНИ ПРИ ЗАСТОСУВАННІ НОРМ КРИМІНАЛЬНОГО ПРАВА
Authors: Завгородній В. А.
Published: April 2023

У статті з’ясовано питання джерельності практики Європейського суду з прав людини для кримінального права України, а також визначено особливості урахування правових позицій Суду Ради Європи при застосуванні кримінально-правих норм. Установлено, що в юридичній доктрині досі триває дискусія з приводу розгляду практики Європейського суд з прав людини джерелом кримінального права, оскільки вона розглядається або як частина національного законодавства, або як судовий прецедент, або як додаткова підстава для кримінально-правової кваліфікації. Доведено, що джерелом кримінального права виступає не сама практика Суду Ради Європи, а правові позиції Європейського суду з прав людини, що є структурною частиною його рішень та результатом легального, делегованого та казуального тлумачення норм Конвенції. Стверджено, що при застосуванні норм кримінального права України першочерговими для урахування є правові позиції Європейського суду з прав людини, що сформульовані ним у рішеннях проти України. Звернення до рішень Страсбурзького суду, ухвалених проти інших держав-учасниць Конвенції, є виправданим лише за умови, коли в рішеннях проти України немає релевантної правової позиції стосовно предмету розгляду. Наголошено, що при виникненні колізії між правовими позиціями Конституційного Суду України та Європейського суду з прав людини суб’єкт застосування норм кримінального права, передусім, має послугуватися юридичними висновками Суду Ради Європи. Під урахуванням практики Європейського суду з прав людини при застосуванні норм кримінального права запропоновано розуміти юридично значущу поведінку суб’єктів застосування кримінально-правових норм, що забезпечує усвідомлення ними важливості результатів правотлумачної діяльності Суду Ради Європи і має своїм наслідком дотримання та виконання вказаними суб’єктами приписів Конвенції про захист прав людини й основоположних свобод шляхом урахування релевантних висновків Страсбурзького суду.
Impacto en la familia del diagnóstico de Trastorno del espectro del autismo (TEA) en un hijo/a: una revisión sistemática
Authors: Lavado-Candelario Sofía , Muñoz-Silva Alicia
Published: April 2023

En la presente revisión sistemática se analiza el impacto que tiene sobre la familia el diagnóstico de Trastorno del espectro del autismo (TEA) en un hijo o hija. Se obtuvieron un total de 44 trabajos publicados entre 2009 y 2023, cuyos hallazgos indican que el diagnóstico de TEA puede alterar la calidad de vida -con una notable presencia de estrés- y el funcionamiento familiar, con efectos en las relaciones de pareja, las relaciones padres-hijos/as con TEA y con desarrollo típico, así como en los hermanos/as del menor diagnosticado. Dicho impacto está mediado por variables como el apoyo social o los estilos cognitivos paternos. Por todo ello, resultan cruciales las intervenciones para dotar a las familias de estrategias para manejar tanto el impacto del diagnóstico como el día a día con sus hijos e hijas. Por último, futuras investigaciones deberían profundizar en los temas menos explorados como las consecuencias para los hermanos.
Influencia del lenguaje abreviado de redes sociales en el procesamiento de la información
Authors: Martín Barrado Antonio David
Published: April 2023

Desde el uso de los mensajes SMS se ha venido utilizando un lenguaje escrito cada vez más abreviado, que lejos de parecer una deformación del lenguaje, sigue un código único y especial que ha “evolucionado” entre los usuarios activos de las “nuevas” redes sociales. En este trabajo se busca determinar el grado de recuerdo en los mensajes abreviados de Whatsapp en una muestra de 32 participantes, divididos en jóvenes (20-25 años) y adultos (45-55 años). De igual forma, se investiga el coste cognitivo que supone la lectura de un mensaje abreviado con emoticonos frente a uno no abreviado siguiendo la normativa de la RAE. De este análisis se obtienen varias conclusiones principales. La primera es que el lenguaje abreviado es capaz de transmitir la información más destacada a costa de un mayor tiempo de lectura, aunque los sujetos se vean competentes. Segundo, hay mayores ideas principales en hombres adultos y mujeres jóvenes. Tercero, hay un mayor número de ideas distorsionadas para los adultos de la condición abreviada y jóvenes sin abreviar. Todo esto hace que este lenguaje tenga unas características y finalidad que lo hace ser un lenguaje vivo y único.
Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices
Authors: Rodríguez Cristian F. , Andrade-Pérez Valentina , Vargas María Camila , Mantilla-Orozco Andrés , Osma Johann F. , Reyes Luis H. , Cruz Juan C.
Published: April 2023

Microfluidics is an interdisciplinary field that encompasses both science and engineering, which aims to design and fabricate devices capable of manipulating extremely low volumes of fluids on a microscale level. The central objective of microfluidics is to provide high precision and accuracy while using minimal reagents and equipment. The benefits of this approach include greater control over experimental conditions, faster analysis, and improved experimental reproducibility. Microfluidic devices, also known as labs-on-a-chip (LOCs), have emerged as potential instruments for optimizing operations and decreasing costs in various of industries, including pharmaceutical, medical, food, and cosmetics. However, the high price of conventional prototypes for LOCs devices, generated in clean room facilities, has increased the demand for inexpensive alternatives. Polymers, paper, and hydrogels are some of the materials that can be utilized to create the inexpensive microfluidic devices covered in this article. In addition, we highlighted different manufacturing techniques, such as soft lithography, laser plotting, and 3D printing, that are suitable for creating LOCs. The selection of materials and fabrication techniques will depend on the specific requirements and applications of each individual LOC. This article aims to provide a comprehensive overview of the numerous alternatives for the development of low-cost LOCs to service industries such as pharmaceuticals, chemicals, food, and biomedicine.
The role of Curcuma longa essential oil in controlling acute toxoplasmosis by improving the immune system and reducing inflammation and oxidative stress
Authors: Ezzatkhah Fatemeh , Mahmoudvand Hossein , Raziani Yosra
Published: April 2023

Background

Chemotherapy with synthetic drugs is the principal approach for toxoplasmosis treatment; however, recent studies reported the limitations and adverse side effects of these chemical drugs.

Objective

This study aimed to examine the in vitro and in vivo effects of Curcuma longa essential oil (CLE) against the Toxoplasma gondii RH strain.

Methods

The in vitro effect of different concentrations of CLE on T. gondii tachyzoites was assessed by cell viability assay. Flow cytometry and apoptosis analysis were performed, and nitric oxide production by CLE was also evaluated in tachyzoites. BALB/c mice were orally treated with various doses (1.25, 2.5, and 5 mg·kg−1·day−1) of CLE for 2 weeks. After the induction of acute toxoplasmosis in the mice, their survival rate and the mean number of peritoneal parasites were checked. The hepatic level of antioxidant enzymes and oxidative stress markers was evaluated by commercial kits. The mRNA expression level of proinflammatory cytokines such as interleukin 1-beta (IL-1β) and interferon-gamma (IFN-γ) was evaluated by quantitative real-time PCR.

Results

CLE, especially at 50 µg/ml, showed potent inhibitory effects on T. gondii tachyzoites. It increased the survival rate (ninth day) and reduced the mean number of peritoneal tachyzoites in the infected mice. CLE dependently increased (p < 0.01) the number of necrotic and apoptotic cells as well as NO production. CLE significantly (p < 0.05) reduced the hepatic level of oxidative stress markers but increased (p < 0.001) the antioxidant enzymes and proinflammatory cytokines in the infected mice, with no important toxicity for vital organs.

Conclusion

The findings of this survey revealed the significant in vitro inhibitory effects of CLE on T. gondii tachyzoites. The results also exhibited promising in vivo effects of CLE. CLE improved the survival rate of infected mice and reduced the parasite number in them. Although the mechanisms of action of CLE are not clear, our study demonstrated its beneficial effects on acute toxoplasmosis by strengthening the immune system and reducing inflammation and oxidative stress. Still, more studies are required to confirm these results.
The controlling nutritional status score predicts postoperative mortality in patients with ruptured abdominal aortic aneurysm: a retrospective study
Authors: Ye Sheng-Lin , Xiang Guang-Yuan , Liu Zhao , Li Wen-Dong , Tang Tao , Qian Ai-Min , Li Xiao-Qiang , Sun Li-Li
Published: April 2023

Background

Ruptured abdominal aortic aneurysms (rAAAs) are challenging for vascular surgeons because they have a high mortality rate. In many diseases, nutritional status is closely associated with prognosis. The Controlling Nutritional Status (CONUT) screening tool score is a prognostic factor in some malignant and chronic diseases; however, the impact of nutritional status on rAAA has not yet been reported. In this study, we explored the relationship between the CONUT score and the postoperative prognosis of patients with rAAA.

Methods

This was a retrospective review of 39 patients with rAAA who underwent surgical treatment from March 2018 to September 2021 at one center. Patient characteristics, nutritional status (CONUT score), and postoperative status were recorded. The patients were divided into groups A and B based on the CONUT score. The baseline characteristics of the two groups were compared, and Cox proportional hazards and logistic regression analyses were used to determine independent predictors of mid-term mortality and complications, respectively.

Results

The overall mid-term mortality rate was 28.21% (11/39). Compared with group A, group B had higher intraoperative (P = 0.047) and mid-term mortality (P = 0.033) rates. The univariate analysis showed that age [hazard ratio (HR), 1.098; 95% confidence interval (CI), 1.019–1.182; P = 0.014], CONUT score (HR, 1.316; 95% CI, 1.027–1.686; P = 0.03), and surgical procedure (HR, 0.127; 95% CI, 0.016–0.992; P = 0.049) were associated with mid-term mortality, whereas the multivariate analysis showed that the CONUT score (HR, 1.313; 95% CI, 1.009–1.710; P = 0.043) was an independent predictor of mid-term mortality. The multivariate logistic regression analysis did not reveal any associations with complications. The Kaplan–Meier curves showed that group B had a lower mid-term survival rate (log-rank P = 0.024).

Conclusion

Malnutrition is closely associated with the prognosis of patients with rAAA, and the CONUT score can be used to predict mid-term mortality.
Tale of two hearts: a TNNT2 hypertrophic cardiomyopathy case report
Authors: Pham Justin H. , Giudicessi John R. , Tweet Marysia S. , Boucher Lauren , Newman D. Brian , Geske Jeffrey B.
Published: April 2023

Hypertrophic cardiomyopathy (HCM) is a heritable cardiomyopathy that is predominantly caused by pathogenic mutations in sarcomeric proteins. Here we report two individuals, a mother and her daughter, both heterozygous carriers of the same HCM-causing mutation in cardiac Troponin T (TNNT2). Despite sharing an identical pathogenic variant, the two individuals had very different manifestations of the disease. While one patient presented with sudden cardiac death, recurrent tachyarrhythmia, and findings of massive left ventricular hypertrophy, the other patient manifested with extensive abnormal myocardial delayed enhancement despite normal ventricular wall thickness and has remained relatively asymptomatic. Recognition of the marked incomplete penetrance and variable expressivity possible in a single TNNT2-positive family has potential to guide HCM patient care.
Variation in the surface radiation budget over different land covers in a subtropical humid region: evidence from ground observations
Authors: Feng Huihui , Wang Shihan , Xiong Jian , Zou Bin , Wang Wei
Published: April 2023

The surface radiation is a crucial variable for understanding global climate and eco-environment change, which exhibits significant variations over time and space. In this study, we used in situ ground observations to estimate variations of the surface radiation budget over grassland and urban areas in a subtropical humid region. Our results revealed a positive radiation budget that varied over different land covers. Specifically, grassland exhibited a higher shortwave radiation, while urban area was characterized by the higher longwave radiation. Notably, the surface radiation budget (Rn) was much greater in grassland (77.60 W2/m) than that in urban area (61.93 W2/m), which was mainly attributed to the difference in longwave radiation. Additionally, the atmospheric pressure showed a strong correlation with the radiations, while precipitation and relative humidity presented relatively weak correlations. Furthermore, the correlations with climate were stronger in grassland than that in urban areas, suggesting complex interactions with anthropogenic factors during the process of urbanization. Results of this study would help reveal the characteristics and corresponding mechanisms of surface radiation budgets, which would support climatic adaptation and ecology management.