bluuebunny/crossref_metadata_2025 huggingface dataset:
PROCOLLAGEN TYPE III N-TERMINAL PEPTIDE (P3NP) AND LEAN MASS: A CROSS-SECTIONAL STUDY
Authors: BERRY S.D. , RAMACHANDRAN V.S. , CAWTHON P.M. , GONA P. , MCLEAN R.R. , CUPPLES L.A. , KIEL D.P.
Published: August 2021

Background:Procollagen type III N-terminal peptide (P3NP) is released during collagen synthesis inmuscle. Increased circulating P3NP is a marker not only of muscle growth, but also of muscle repair and fibrosis.Thus, P3NP may be a potential biomarker for sarcopenia. Objective: To determine the association betweenplasma P3NP and lean mass and strength. Design, Setting, and Participants:A cross-sectional study of men andwomen from the Framingham Offspring Study. Participants included a convenience sample of 687 members witha measure of plasma P3NP and lean mass, and 806 members with P3NP and quadriceps strength assessment.Measurements:Linear regression was used to estimate the association between total and appendicular lean massand plasma P3NP, and quadriceps strength and P3NP. Results:Mean age was 58 years. Median plasma P3NPwas similar in men (3.4 mg/L), premenopausal women (3.1 mg/L), and postmenopausal women (3.0 mg/L). Inadjusted models, higher P3NP was associated with a modest decrease in total and appendicular lean mass inpostmenopausal women [β= -0.13 unit P3NP/kg total lean mass; p=0.003]. A similar trend was found amongpremenopausal women, although results were not statistically significant [β=-0.10 unit P3NP/kg total lean mass;p=0.41]. No association between P3NP and lean mass was observed in men. P3NP was not associated withstrength in men or women. Conclusion:Our results suggest that plasma P3NP might be a useful biomarker ofmuscle mass in postmenopausal women if longitudinal studies demonstrate that it has adequate sensitivity andspecificity to predict muscle loss.
WHAT IS A “NEIGHBORHOOD”? DEFINITION IN STUDIES ABOUT DEPRESSIVE SYMPTOMS IN OLDER PERSONS
Authors: SIORDIA C. , SAENZ J.
Published: August 2021

The almost irrefutable hypothesis that place matters continues to grow in popularity. Epidemiologicaland public health researchers are studying social and physical environment’s effect on individual healthoutcomes. Advances in the field are hindered by the lack of consistency in measuring and labeling socialcontexts. Greater definitional precision is required. In order to give an example of this, “neighborhood” studiesbetween 2000 and 2012 dealing with depression symptomatology in older adults were identified with anexhaustive search. Only those where the terms neighborhood, and mental health, or mental well-being, or CES-Dappear were included for the initial review. After additionally selecting for age and the presence of the Center forEpidemiologic Studies Depression (CES-D) measure, from an initial 98 articles, we end up with 11 articles. Wefocus on how neighborhoods are defined and briefly highlight findings on CES-D. For the most part, thedefinition of neighborhood is limited, frequently justified, and typically hidden in the methodological details andclosing arguments of an article. In general, articles evade the discussion of polygon appropriateness with relationto the term neighborhood. Our review suggests that a good starting point for advancing this field of inquiry wouldbe to increase the definitional precision of the term neighborhood and to offer an upfront disclosure with moreappropriate terminology. Doing so may lead place-effect investigations in population aging and frailty down amore productive road.
“EU GOSTO MAIS DAS COISAS QUE BRILHAM!”
Authors: Oliveira da Silva Junior Alcidesio
Published: August 2021

Um corpo minúsculo adentra a sala de aula. Contrastando com sua presença acanhada, uma lufada de desordem é provocada por Mário e seu vestido cor-de-rosa, dando luz a um silêncio atônito, assaltado, da ordem do ineditismo. Por meio de uma cartografia inspirada em Deleuze & Guattari, lanço-me ao curta-metragem Vestido Nuevo (2007) com uma pergunta: e se gênero fosse um Carnaval? Em diálogo com os Estudos Culturais da Educação e os Estudos da Performance, concluo o texto dizendo que Mário, como um currículo-performance, um corpo transviado, queer, anarquista, ensaia passos de frevo, de fervor, piruetas que fogem às investidas cinzentas do cotidiano heteronormativo.
PRECISAMOS VERDADEIRAMENTE DE UM VERDADEIRO SEXO?
Authors: Inocêncio Adalberto Ferdnando , De Carvalho Fabiana Aparecida
Published: August 2021

Apresenta-se uma análise do documentário “Laerte-se” a partir da problematização da necessidade de um sexo verdadeiro e de modos de afirmação da identidade transgêneras da cartunista em questão. Para tal, com base em teorizações foucaultianas e feministas, discute-se: a) o verdadeiro sexo como tática de governamento; b) as disputas narrativas; e, c) e o domínio ético da transgeneridade na vida como obra de arte em “Laerte-se”. Espera-se, com a discussão, visibilizar a existência das pessoas trans e a vida da cartunista a partir de seu processo de construção de uma nova feminilidade para si.
ATYPICAL: NEURODIVERSIDADE E PEDAGOGIA DA SEXUALIDADE
Authors: Cruz Pâmela Suelen Gama da , Altmann Helena
Published: August 2021

Por meio da análise fílmica da série Atypical, produzida pela Netflix, este trabalho tem o intuito de indagar como as particularidades do personagem autista Sam Gardner, em relação a sua sexualidade e forma de socializar-se, pode nos trazer reflexões sobre o alcance das pedagogias da sexualidade nas relações sociais. Sam compartilha as angústias de viver em uma sociedade capacitista e as dificuldades para assimilar as regras sociais que permeiam a criação de laços afetivos. A partir do entendimento das pedagogias da sexualidade, enquanto o processo disciplinamento dos corpos, mediante práticas discursivas e não-discursivas, conclui-se que a constituição de laços afetivos é permeada por um regime que busca normatizar condutas. Assim sendo, a não reprodução das imposições sociais acabam por gerar a patologização de singularidades. Portanto, ressalta-se a relevância do movimento da neurodiversidade em prol da fluidez de corpos e experiências tidas como abjetas e, portanto, marginalizadas.
Educação Ambiental na perspectiva de Rachel Carson
Authors: Oliveira Morgana Maciél , Uhmann Rosangela Inês Matos
Published: August 2021

O presente trabalho tem por objetivo fazer uma discussão sobre a Educação Ambiental (EA) respectivo à pesquisadora Rachel Carson em atenção ao livro: Primavera Silenciosa, bem como estudos referenciados da pesquisadora investigados nos trabalhos apresentados nos Encontros Nacionais realizados pela Associação Nacional de Pós-Graduação e Pesquisa em Educação (Anped). O método de busca qualitativa foi de análise nos trabalhos publicados da 26ª à 38ª edição da Reunião Nacional do Anped. Portanto, mesmo passando tanto tempo em que a obra foi lançada, ainda carecemos ampliar o conhecimento sobre o uso abusivo dos agrotóxicos atualmente, por exemplo, de forma controversa, ligados ao cunho social, político, ambiental, cultural e econômico.
A discussão da subjetividade na produção teórica sobre Educação Ambiental e formação de professores de Biologia
Authors: Sales Raquel de Oliveira , Bicalho Maria Gabriela Parenti , Santos Thiago Martins
Published: August 2021

Este trabalho apresenta resultados de uma dissertação que analisa a presença de discussões relativas à subjetividade na produção teórica sobre Educação Ambiental (EA) e formação de professores de Biologia, publicada pela Scientific Eletronic Library Online (SciELO) entre 2008 e 2018. A partir da adoção de três conjuntos de termos de busca, foram identificados 27 artigos, cuja análise revelou a presença da discussão sobre a subjetividade na proposta de associação da natureza à cultura; na adoção dos termos percepção, concepção, identidade, sentido e significado na elaboração de problemas de pesquisa; e na utilização de metodologias participativas e colaborativas. O material analisado permite identificar as discussões sobre subjetividade na adoção de determinadas categorias teóricas e na utilização de metodologias participativas nas pesquisas realizadas com professores.
Centro de Educação Ambiental Municipal do Parque Nacional da Tijuca
Authors: Diafilos Teixeira Joana , Fonseca de Andrade Daniel , Borges Rocha Marcelo
Published: August 2021

Este artigo teve como objetivo investigar a atuação de um minicurso voltado para a formação ambiental de docentes no Estado do Rio de Janeiro. O minicurso foi oferecido pelo Centro de Educação Ambiental Municipal do Parque Nacional da Tijuca, que realiza ações educativas dentro do Parque Nacional da Tijuca. Os dados coletados, a partir de questionários com perguntas abertas e fechadas, foram analisados à luz da Análise de Conteúdo. Os resultados apontaram que os docentes tinham formação em diferentes áreas do conhecimento, estavam inseridos em diferentes regiões do estado e passaram a introduzir na sala de aula práticas discutidas durante o curso. Isso indica a importância do Centro para a formação continuada docente e que iniciativas deste tipo devem ser incentivadas em outras áreas protegidas.
Noções Foucaultianas para o campo da Educação Ambiental
Authors: Garré Bárbara Hees
Published: August 2021

RESUMO: O presente texto refere-se a um recorte de tese de doutorado que teve como propósito analisar de que modo a revista Veja coloca em funcionamento e potencializa o dispositivo da Educação Ambiental no século XXI. Aqui, em especial, o foco de discussões situa-se em mapear conceitos muito potentes que subsidiaram a pesquisa. Desse modo, a sistematização situa-se em algumas discussões importantes sobre o pensamento do filósofo francês Michel Foucault que se constituem como ferramentas analíticas para o campo da Educação Ambiental. A intenção do trabalho é provocar o leitor a pensar no modo pelo qual a mídia vem atuando como uma pedagogia cultural e, dessa maneira, ensinando as formas corretas de ser, pensar e agir frente às questões ambientais. Como metodologia, utiliza-se de algumas ferramentas foucaultianas da análise do discurso. Problematiza os processos de subjetivação imbricados nas tramas de um dispositivo que é cada vez mais potente e incide sobre a vida dos sujeitos na atualidade.

Palavras-chave: Educação Ambiental; Michel Foucault; Dispositivo.
La (re) generación de la condición humana: la Educación Estético-Ambiental
Authors: Estévez Rodríguez Pablo René
Published: August 2021

El trabajo analiza el impacto anestésico y antiestético de la crisis socioambiental en la condición humana, y el proceso de su regeneración mediante la Educación Estético-Ambiental (EEA). A partir de un esbozo de las causas que han conducido a la desarmonía en la naturaleza humana y no humana, y en consecuencia, a la pérdida de la sustentabilidad estética en el proceso de desarrollo histórico-natural de la especie Homo sapiens, se pondera el papel de la sensibilización estético-ambiental en la preservación y/o rescate de los sentidos “estéticos”. Finalmente, se hace un recuento de las experiencias de sensibilización estético-ambiental realizadas con estudiantes, instructores de arte, profesores y miembros de la comunidad, en espacios educacionales de Brasil, Cuba y Chile.
The Sulfur Microbial Diet and Risk of Colorectal Cancer by Molecular Subtypes and Intratumoral Microbial Species in Adult Men
Authors: Sikavi Daniel R. , Nguyen Long H. , Haruki Koichiro , Ugai Tomotaka , Ma Wenjie , Wang Dong D. , Thompson Kelsey N. , Yan Yan , Branck Tobyn , Wilkinson Jeremy E. , Akimoto Naohiko , Zhong Rong , Lau Mai Chan , Mima Kosuke , Kosumi Keisuke , Morikawa Teppei , Rimm Eric B. , Garrett Wendy S. , Izard Jacques , Cao Yin , Song Mingyang , Huttenhower Curtis , Ogino Shuji , Chan Andrew T.
Published: August 2021

INTRODUCTION:

We recently described the sulfur microbial diet, a pattern of intake associated with increased gut sulfur-metabolizing bacteria and incidence of distal colorectal cancer (CRC). We assessed whether this risk differed by CRC molecular subtypes or presence of intratumoral microbes involved in CRC pathogenesis (Fusobacterium nucleatum and Bifidobacterium spp.).

METHODS:

We performed Cox proportional hazards modeling to examine the association between the sulfur microbial diet and incidence of overall and distal CRC by molecular and microbial subtype in the Health Professionals Follow-Up Study (1986–2012).

RESULTS:

We documented 1,264 incident CRC cases among 48,246 men, approximately 40% of whom had available tissue data. After accounting for multiple hypothesis testing, the relationship between the sulfur microbial diet and CRC incidence did not differ by subtype. However, there was a suggestion of an association by prostaglandin synthase 2 (PTGS2) status with a multivariable adjusted hazard ratio for highest vs lowest tertile of sulfur microbial diet scores of 1.31 (95% confidence interval: 0.99–1.74, P
trend = 0.07, P
heterogeneity = 0.04) for PTGS2-high CRC. The association of the sulfur microbial diet with distal CRC seemed to differ by the presence of intratumoral Bifidobacterium spp. with an adjusted hazard ratio for highest vs lowest tertile of sulfur microbial diet scores of 1.65 (95% confidence interval: 1.14–2.39, P
trend = 0.01, P
heterogeneity = 0.03) for Bifidobacterium-negative distal CRC. We observed no apparent heterogeneity by other tested molecular markers.

DISCUSSION:

Greater long-term adherence to the sulfur microbial diet could be associated with PTGS2-high and Bifidobacterium-negative distal CRC in men. Additional studies are needed to further characterize the role of gut microbial sulfur metabolism and CRC.
Die Republik vom 8. Mai 1980: "Gustave Flaubert: 12. Dezember 1821 - 8. Mai 1880"
Authors: Stanitzek Georg
Published: August 2021

Der Beitrag von Georg Stanitzek stellt die Zeitschrift »Die Republik« von Petra und Uwe Nettelbeck vor - und insbesondere den Gustave Flaubert gewidmeten Beitrag vom 8. Mai 1980.
Europa als Grenze
Authors: Kasparek Bernd
Published: August 2021

Mit der Europäischen Grenz- und Küstenwachagentur Frontex hat die Europäische Union erstmalig eine uniformierte und bewaffnete Polizeieinheit geschaffen. Bernd Kasparek legt eine detaillierte Analyse der Entstehung und Entwicklung der Agentur vor. Durch eine Genealogie der europäischen Grenze und eine ethnographische Rekonstruktion der Krise Schengens untersucht er das lange Projekt der Europäisierung des Grenzschutzes. Im Zentrum steht die Analyse sich wandelnder Rationalitäten, die sich in politischen und technischen Programmatiken niederschlagen. Dabei wird deutlich, dass das Regieren der Grenze und der Migration gleichzeitig die Frage nach dem Regieren Europas bedeutet
EFEKTIVITAS OPAC SEBAGAI SARANA TEMU KEMBALI INFORMASI DI UPT PERPUSTAKAAN UNIVERSITAS MUHAMMADIYAH MAGELANG (UNIMMA)
Authors: Isnaini Rizki Shofak , Widayati Jamzanah Wahyu
Published: August 2021

Evaluation of information retrieval tool is very important to find out how far the retrieval system has worked. This study evaluates the OPAC of Muhammadiyah University of Magelang (UNIMMA) by determining the effectiveness of the information retrieval system seen from the relevance of the data displayed with the data requested by the user. This is descriptive quantitative research that calculates the value of recall and precision, while the data collection is conducted through literature studies and documentation. Based on the data collected, it can be concluded that OPAC UNIMMA is in the effective category with a high level of precision, and in the value range of 0.68 - 1.00 with recall and precision values respectively 0.77 or 77% and 0.84 or 84%. However, from the observations on each class number, it is found that the class number has a higher recall value than the precision, ie: the class numbers of 200, 800, and 900.
Soil Physico Chemical Properties and Macronutrients Evaluation during Sowing and after Harvesting of Crop at High Altitude Leh Ladakh India
Authors: Kumar Krishna , Giri Arup , Bharti Vijay K. , Kumari Preeti , Kumar Sunil , Bhardwaj Ajay Kumar , Chaurasia O.P.
Published: August 2021

The present study was aimed to investigate the effect of physico-chemical parameters and soil macro-nutrients to know the nutrient uptake status during sowing time (ST) and after the harvesting (AH) of crops of Leh-Ladakh. In this context, total 55 no. of soil samples were collected from the eleven villages. Thereafter, soil texture, pH, electrical conductivity (EC), total dissolved solids (TDS), organic carbon (OC), nitrogen (N), phosphorus (P), and potassium (K) were analyzed as per the standard methods. The results exhibited variation in different studied parameters at ST and AH, are OC (ST- 1.70 ± 0.11; AH-2.31±0.08), N (ST- 171.54±11.40; AH- 212.03±13.18), P (ST- 75.62±8.16; AH- 96.32±11.56), pH (ST- 8.12±0.05; AH- 8.16±0.06), EC (ST- 0.48±0.04; AH- 0.58±17), TDS (ST-309±22.41; AH-189±16.42) and soil texture gradient (Sand: ST-75.16±1.27 & AH-71.75±1.26, Silt: ST- 18.55±1.09 & AH- 20.66±1.02 and clay: ST- 6.33±0.53 & AH- 7.76±0.63). The comparison of physico-chemical parameters, macronutrients, soil texture, and organic carbon at sowing time (ST) and after harvesting (AH) revealed significant difference in some macronutrients, EC, and organic carbon, whereas no changes were observed in soil texture, pH and phosphorus. Hence, this study highlights the need of physico-chemical parameters management during crops sowing for enhancing macronutrients availability to crops in trans-Himalayan high altitude region.
Visual Performance under Varying Illumination Conditions while using an Indigenously Developed Wrist Wearable Computer
Authors: Mondal Kiran , Bhattacharyya Debojyoti , Majumdar Deepti , Meena Roshani , Pal Madhusudan
Published: August 2021

Ambient illumination conditions have significant impact on users’ visual performance while carrying out onscreen reading tasks on visual display units, especially smaller screen sizes. Present study assessed the visual performance responses of different ambient illumination levels during onscreen reading on Wrist Wearable Computer (WWC) developed for the command-control-communication between the control room and the soldiers operating in remote locations. Ten (10) Indian Infantry soldiers performed two different types of loud reading tasks on the display of WWC under three different ambient illumination (mean ±SEM) conditions namely, Indoor controlled (450.00±10.00 lx), Outdoor daylight (11818.7±582.91 lx) and Indoor dark (0.12±0.03 lx) environments. While reading, participants wore an eye tracking glass which recorded the eye movement responses. Visualisation techniques were used to predict the association of illumination levelof surrounding with visual performance of the user. Subjective legibility rating was also applied to understand participants’ preferences towards physical attributes of the onscreen information and illumination level. Results indicated that illumination had a significant effect on eye movement parameters like fixation frequency, fixation duration and scanpath length while completing the tasks. Overall, participants performed better under indoor controlled illumination conditions in terms of fixation profile and scanpath length, apart from improved subjective legibility ratings as compared to other two illumination conditions. Future research attempts need to be directed towards the optimum performance of the display across wide range of ambient illumination conditions and to establish how the display of indigenously developed wearable computer performs in comparison to other such displays available across the globe.
Estudio y análisis comparativo de interacciones entre la proteina integrina con fragmentos de la proteína fibrilina-1 y fragmentos mutados de esta utilizando la metodología de docking molecular
Authors: Vivas-Reyes Ricardo , Tirado Yamiris , Valdiris Verónica
Published: August 2021

Objetivo: Evaluar las interacciones proteína-proteína que pueden darse entre fragmentos de la proteína fibrilina-1, cuyas mutaciones causan el síndrome de Marfan (SM). Materiales y métodos: Se realizaron una serie de cálculos docking proteína-proteína entre las macromoléculas de interés se empleó el programa Molsoft ICM, se utilizaron las estructuras cristalinas de la proteína Integrina αVβ3 y de fragmentos de la proteína fibrilina-1, además se generaron mutaciones en la fibrilina-1, las cuales son características en pacientes con síndrome de Marfan, realizando posteriormente el acoplamiento molecular. Se determinó los aminoácidos que con mayor frecuencia estaban presentes en el sitio de interacción y su hidrofobicidad. Resultados: Se cuantifico la cantidad de aminoácidos hidrófobos presentes en las zonas de interacción dadas por los acoplamientos, teniendo en cuenta la energía del sistema, estuvo entre el 40 y 50 % de los aminoácidos de la zona de interacción, con un porcentaje mayor con respecto a aminoácidos neutros o cargados. En los resultados obtenidos utilizando las mutaciones realizadas sobre los fragmentos cbEGF22-TB4-cbEGF23 y cbEGF9-hyb2-cbEGF10 de la fibrilina-1, se encontró que no se ubicaron en zonas cercanas al sitio de interacción en la mayoría de los casos. Conclusiones: Las interacciones entre los fragmentos de fibrilina-1, y estos con respecto a la integrina mostraron en sus zonas de interacción la presencia mayoritariamente de aminoácidos hidrofóbicos, que es lo esperado normalmente.
Phase analysis to measure left ventricular dyssynchrony by Gated-SPECT myocardial perfusion imaging showed by two different software
Authors: Marín Oyaga Víctor , Gutiérrez Villamil Claudia , Dueñas Criado Karen , Arévalo Leal Sinay
Published: August 2021

Conclusión Realizar el análisis fase de análisis por GS-PMI es factible. Sin embargo la DE mostró diferencias significativas entre los dos programas. Aunque los valores mostrados podrían ser utilizados como valores normales, se recomienda que éstos se obtengan y utilicen para cada programa por separado.
Behavioral Assessment of productivity and profitability Indicators in Health Provider companies from the Contributory Schemein Colombia
Authors: Fontalvo Herrera Tomás J. , Mendoza Mendoza Adel A. , Visbal Cadavid Delimiro A.
Published: August 2021

Objetivo: Analizar el comportamiento que han sufrido los indicadores de productividad y rentabilidad financieros en las Empresas Prestadoras de Salud del régimen contributivo en Colombia. Materiales y métodos: Estudio cualitativo, descriptivo propositivo y cuantitativo soportado en un Análisis Discriminante Multivariado (ADM), que permite analizar diferencias significativas durante los periodos 2008 y 2010. Se definen y calculan los indicadores de productividad y rentabilidad financieros analizando las diferencias significativas y medias de los periodos estudiados. Resultados: Se pudo evidenciar y demostrar en el trabajo de investigación que en el análisis de las medias del indicador Utilidad Operacional / Valor agregado (IP2) presentó diferencias significativas. Para el análisis de la función discriminante mejoraron los indicadores Utilidad Bruta / Ingresos Operacionales (MB) y Utilidad Operacional / Valor agregado (IP2) durante los periodos 2008 y 2010 en las Entidades Prestadoras de Salud del régimen contributivo. Conclusiones: Según el trabajo de investigación se pudo concluir por el Análisis Discriminante Multivariado que existe una diferencia significativa en los dos periodos estudiados, el modelo de la función discriminante permite predecir el comportamiento de la población a futuro con un 61,1 % de probabilidad.
Implementation of Clinical Practice Guideline (CPG) for early detection, diagnosis and comprehensive care of the depressive episode and recurrent depressive disorder in adults at Hospital Universitario Cari ESE Neurociencias de Barranquilla (Colombia)
Authors: Navarro - Jiménez Eduardo , Laborde - Cárdenas Carmen , Gómez - Méndez Pedro , Fontalvo Morales Rosa
Published: August 2021

Objetivo: Implementar una Guía de Práctica Clínica (GPC) para la detección temprana y diagnóstico del episodio depresivo y trastorno depresivo recurrente en adultos, en los servicios de consulta prioritaria, consulta externa y hospitalización del Hospital Universitario Cari ESE Neurociencias de la ciudad de Barranquilla. Materiales y métodos: Se desarrolló el Plan de implementación de una GPC de manejo de episodio depresivo y trastorno depresivo recurrente, de acuerdo a la metodología del manual de implementación de guías de práctica clínica basadas en evidencia del Ministerio de salud. El instrumento de recolección de datos utilizado fue el cuestionario. Se indagó acerca de la preparación académica, el tiempo laborado en el ESE Cari Mental y la experiencia profesional específica; así, como del manejo que tienen en su vida profesional y preferencias las GPC – depresión. Resultados: La GPC elegida por consenso fue la Guía de Práctica Clínica (GPC) para la detección temprana y diagnóstico del episodio depresivo y trastorno depresivo recurrente en adultos, atención integral de los adultos con diagnóstico de episodio depresivo o trastorno depresivo recurrente. Conclusiones: La demanda de servicios de salud siempre parece ser superior a la cantidad de recursos disponibles para satisfacerla. La anterior afirmación es válida en todas las sociedades, aún en los países clasificados como de altos ingresos. Es por ello, que la adopción de GPC en el contexto clínico – administrativo de la ESE Cari mental – incluyendo los demás entes territoriales – es una decisión que redunda en la racionalización del recurso humano y administrativo, el cual siempre será escaso.
Molecular pathophysiology in infection by Helicobacter pylori
Authors: Torres Jiménez Franklin , Torres Bayona Carlos
Published: August 2021

La infección por Helicobacter pylori es la infección bacteriana más común a nivel mundial, en 1994 la Agencia Internacional para la Investigación en Cáncer catalogó al Helicobacter Pylori como un carcinógeno tipo I. La infección por ésta bacteria incrementa el riesgo de padecer cáncer gástrico hasta 6 veces más que los individuos que no presentan la infección. Colombia tiene una prevalencia de infección por Helicobacter pylori del 86% en adultos mayores de 20 años y del 80% en niños mayores de 8 años. La infección persistente y recidivante de la mucosa gástrica puede generar una respuesta inflamatoria, o procesos silentes, que en el peor de los casos puede progresar a un adenocarcinoma gástrico tipo difuso o intestinal. Existen múltiples factores que influyen en las consecuencias clínicas de la infección por Helicobacter pylori, en mención: predisposición genética del huésped, inmunorregulación genética del paciente infectado, factores ambientales y heterogeneidad de los factores de virulencia de las diversas cepas. Por lo anterior se infiere que las patologías gástricas, en especial la gastritis y el adenocarcinoma, son padecimientos de etiología multifactorial que pueden originarse por diversas causas o condiciones. En la presente revisión se analizarán los principales aspectos relacionados con la fisiopatología molecular en la infección por Helicobacter pylori, en particular tópicos correspondientes a los factores de virulencia.
Pengaruh Infiltrasi Levobupivakain pada Skor Histologis MHC Kelas 1 pada Penyembuhan Luka
Authors: Primatika Aria Dian , Budiono Uripno , Eksana Ery
Published: August 2021

Latar belakang: Nyeri akut pasca pembedahan memicu timbulnya gejala klinis patofisiologis, menekan respons imun, sehingga menyebabkan penurunan sistem imun yang akan menghambat penyembuhan luka. Levobupivakain, anestetik lokal durasi panjang yang efektif mengurangi nyeri akut. MHC kelas I sebagai petanda permukaan sel yang terinfeksi memberi sinyal pada sel T sitotoksik sehingga fungsinya dalam respons imun sangat penting. Kemampuan limfosit T sitotoksik untuk melisiskan sel merupakan fungsi langsung dari banyaknya MHC kelas I yang diekspresikan.Tujuan: Membuktikan pengaruh infiltrasi anestetik lokal levobupivakain terhadap ekspresi MHC kelas I.Metode: Dilakukan penelitian eksperimental pada hewan coba, randomized post test only control group design, menggunakan tikus Wistar. Sampel 15 ekor dibagi menjadi 3 kelompok; kelompok I kontrol, kelompok II insisi subkutis tanpa infiltrasi levobupivakain, kelompok III insisi subkutis dan infiltrasi levobupivakain dosis 12,6 mcg/gram BB setiap 8 jam selama 24 jam. Ekspresi MHC kelas I pada sekitar luka insisi dinilai dengan skor histologi dengan menggunakan pengecatan secara imunohistokimia. Biopsi jaringan diambil pada hari kelima karena pada penyembuhan luka normal jumlah limfosit T bermakna pada hari kelima dan mencapai puncak pada hari ketujuh. Data dianalisis dengan uji beda Kruskal-Wallis.Hasil: Penelitian menunjukan pada kelompok kontrol terdapat ekspresi MHC kelas I dengan hasil rerata skor histologi 4,92. Hasil rerata skor histologi MHC kelas I pada kelompok levobupivakain lebih rendah (8,12) dibanding kelompok tanpa levobupivakain (5,26) dan secara statistik berbeda bermakna (p=0,011).Simpulan: Ekspresi MHC kelas I (skor histologi MHC I) pada kelompok dengan infiltrasi levobupivakain lebih rendah dibandingkan dengan kelompok tanpa infiltrasi levobupivakain.
Henti Jantung Pasca Koreksi Berlebih Natrium Bikarbonat pada Pasien Ketoasidosis Diabetikum di Bangsal Resusitasi Rumah Sakit Pusat Nasional Cipto Mangunkusumo
Authors: Djaja Anne Suwan , Aditianingsih Dita , Yohannes George
Published: August 2021

Latar Belakang: Infus sodium bikarbonat diberikan kepada pasien asidosis dengan pH kurang dari 7,1. Asidosis mematikan / letal, yang berarti pH kurang dari 7,1, akan menonaktifkan enzim dan modulator lain dalam tubuh dan oleh karena itu harus dikoreksi.Kasus: Seorang wanita berusia 51 tahun dirawat di rumah sakit dengan keluhanutama nyeri dada atipikal sejak satu hari yang lalu. Dia memiliki riwayat diabetes mellitus tipe 2, dikontrol dengan metformine 3x500 mg, penyakit ginjal kronis dengan urin produksi 0,6 cc / kg / jam. Riwayat penurunan kesadaran, penyakit serebrovaskular, dan infark miokard disangkal. Saat masuk bangsal perawatan, ia tampak sakit parah, dengan tekanan darah 110/70 mmHg, nadi 65 kali per menit, dan frekuensi napas 32 kali per menit.Ringkasan: Hanya tiga variabel independen yang bisa merubah pH, yaitu ion-ion kuat (SID/ Strong ion Differences), pCO2, dan ATOT. Mekanisme peran natrium bikarbonat dalam meningkatkan pH adalah dengan meningkatkan tingkat SID/ Strong Ion Differences. Pemberian berlebih dari natrium bikarbonat meningkatkan tingkat pH cepat. Itu membuat oksigen tidak dapat memisahkan dari hemoglobin, menyebabkan hipoksia seluler, dan menginduksi kematian sel.
Patofisiologi Penyakit Jantung Koroner
Authors: Satoto Hari Henriarto
Published: August 2021

Sindrom koroner akut adalah suatu kondisi terjadi pengurangan aliran darah ke jantung secara mendadak. Beberapa gejala dari sindrom ini adalah tekanan di dada seperti serangan jantung, sesak saat sedang beristirahat atau melakukan aktivitas fisik ringan, keringat yang berlebihan secara tiba-tiba (diaforesis), muntah, mual, nyeri di bagian tubuh lain seperti lengan kiri atau rahang, dan jantung yang berhenti mendadak (cardiac arrest). Umumnya mengenai pasien usia 40 tahun ke atas walau pada saat ini terdapat kecenderungan mengenai usia lebih muda.
Iphigenia magnifica Ansari & R.S. Rao (Colchicaceae) – A new distributional record to the flora of Eastern Ghats, India
Authors: Vallepu Nagaraju , Mitta Mahendra Nath , Arisdason W
Published: August 2021

Iphigenia magnifica Ansari & R.S. Rao (Liliales: Colchicaceae), an endemic species of Western Ghats is reported in this communication as a new distributional record for Eastern Ghats from Seshachalam hills of Eastern Ghats, Andhra Pradesh. The present communication provides description of this species along with photographs of habitat, live plant and herbarium specimen, comparison with its allied species, ecology and conservation assessment.
Electoral Violence and Democratic Consolidation in Nigeria: Issues and Challenges
Authors: Harry Deinibiteim M. , Kalagbor Samuel B.
Published: August 2021

The study examined the effects of electoral violence on the democratization efforts and democratic consolidation in Nigeria since the beginning of the Fourth Republic in 1999. The nation’s elections, at all levels of governance, are characterized by violence. Violence mar as high as 70 percent of Nigerian elections resulting in deaths, destruction of properties, maiming, etc. Successive governments have made frantic efforts to institutionalize and consolidate democracy in the country, embarking on various electoral reforms with little or no result with respect to curbing electoral violence. Thus, the main objective of this study is to show that the high rate of electoral violence witnessed over the years has weakened and discredited the democratic consolidation drive of the Nigerian state. The theoretical framework adopted in this study is the “State Fragility Theory”. However, the author’s modified version of “State Compromise Theory” was used to analyze the nature, character and reasons for electoral violence in Nigeria and its effects on the institutionalization of democracy in the country. The study used both primary and secondary data. The primary data were mainly drawn from mainly the authors’ observations during elections, over the years, while secondary data were drawn from existing literature on the subject matter. The study revealed that the pervasive violence at different elections has greatly discredited and emasculated democratic governance in the country. Violence has become both physical and cathartic. It manifests in form of wanton shooting by political thugs to intimidate voters and electoral officials, so as to snatch election materials, disruption of voting, vote suppression, cancellation and annulment of elections in opposition strongholds, etc.  The paper concluded that, to ensure the consolidation of democracy in Nigeria, election management bodies must adopt an electoral system that drastically reduces congregation of people at a voting point(s) so as to reduce violence. Some of the recommendations are that election management bodies should deploy appropriate technology to reduce congregation of people at a voting point, transmission of results should be done electronically to minimize human involvement, contacts error and manipulations.
Organization’s Characteristics that Facilitate the Innovation Process and Techniques- Case of Oman
Authors: Matriano Maria Teresa
Published: August 2021

Many global organizations today have shown tremendous growth year after year and the measure of their success is beyond what the competition has achieve. The most common characteristic of the globally successful organizations is their continuous engagement in innovation that not only changes the playing field in the competition, but also creates a disruption in which the influence of the innovation impact social, economic, and political dynamics of the modern world. Facilitating innovation requires strategic approach by organizations in the processes of implementation. Some of the key characteristics of an organization that successfully facilitates the innovation process includes flexibility, openness, agility, adaptiveness, and cultivation. In the case of Oman, facilitating innovation and strategically applying the techniques to achieving positive outcome is a challenge that organizations are striving to overcome. Notable examples of innovation process approach by Omani organizations include creating a network of other organizations that are willing to partake in information exchange. Another example is collaboration in which a less capable organization collaborate with larger firms creating a mutually beneficial partnership to facilitate innovation and development.
Intentional Destruction of Life on Earth
Authors: Herndon J. Marvin , Whiteside Mark
Published: August 2021

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Developing Students’ Prosocial Behavior Through Collaborative Teamwork Teaching
Authors: Muhammad Asrori , Effendy Chairil
Published: August 2021

Developing students’ prosocial behavior is a very important program in the living situation that increasingly complicated, individualistic, and hedonistic. It is important because prosocial behavior refers to voluntary actions that intended to help or benefit another individual or group of individuals. The present study was designed to examine the effectiveness of a collaborative teamwork teaching to develop the prosocial behavior of elementary school students. It was an experimental study with one group pretest-posttest design. The experiment was carried out in three elementary schools. They were Islamic Al-Azhar Elementary School (SD Islam Al-Azhar), State Elementary School 34 (SD Negeri 34), and Muhammadiyah Elementary School (SD Muhammadiyah) Pontianak. There were four aspects of the students’ prosocial behavior to develop. These aspects were sharing, helping, cooperating, and caring. The results of the study showed that the collaborative teamwork teaching was effective to develop the prosocial behavior of students in three elementary schools. All of the investigated aspects got improved. They were categorized “high”, except the aspect of caring. It was classified as “medium”.
Factors Impacting Sumatran Private Medical Students Inclination to Work In Rural Areas
Authors: Fadilah Mariatul
Published: August 2021

At present the progress of Indonesia's health currently has significant problems with the unequal distribution of doctors in rural areas;  doctors are only concentrated in urban areas.  The environment and policies at private universities have a big influence on the educational process, which causes the low interest of private medical students to work in rural areas.  Getting the right results on the pattern of interest in private medical students to work in rural areas will ultimately help policymakers to resolve differences in the distribution of doctors in Indonesia.  This quantitative analytical study was conducted at 12 private medical faculties on the island of Sumatra, Indonesia.  The total sample obtained was 446 active private medical students in 2016 from a total population of 5,106 students.  Data were collected by questionnaire and analyzed using software namely SPSS.  From the results of the binary logistic regression analysis, there are four dominant factors of private students that affect the interest in working in rural areas.  Then a multivariate logistic regression analysis using the enter method was conducted that the tendency of medical students to work in rural areas was 58% for private universities.  By using patterns and student acceptance variables, it is expected to increase the interest of private medical students working in rural areas, and ultimately be able to distribute doctors equally in Indonesia.
Management of software development projects in Brazil using agile methods
Authors: Ravaglia Claudia Carrijo , Mexas Mirian Picinini , Dias Ana Claudia , Batista Haydée Maria Correia da Silveira , Nunes Kleber da Silva
Published: August 2021

The aim of the paper is to analyze how agile management practices are being adopted by specialists from software development technology companies in Brazil, identifying actions that contribute to the success of software implementation, aiming to ensure the survival of organizations in the market. The study counted with a literature review to support the field research with software development specialists who use the agile methodology and work in Brazil in the states of Rio de Janeiro and São Paulo. The results were analyzed through a descriptive statistics and content analysis. The research identified that the companies that adopt agile software management methodology in Brazil prefer the Scrum method and the development teams may be geographically distributed. The main positive points identified when adopting agile methods were the process speed, team involvement, maximization of results, involvement with the client, and simplicity. Most experts identified problems in the implementation of the agile methodology and as points of attention: management of distributed teams, scope estimation and communication. It was possible to identify the existence of a positive financial result by adopting the agile method for software development projects, as well as actions that contribute to the success of these projects, such as controlling quality using different testing techniques, project management, time, stakeholders, scope, and have agile communication, with feedback and good leadership. On the other hand, it was observed in the statistics that, although efficient, this method is still not being widely used. This research can contribute to the managers of software development companies in the use of agile methods as well as improving management decision-making.
Relationship between developing manager and managerial economics: a theoretical overview
Authors: Rahman Md. Hasanur , Majumder Shapan Chandra
Published: August 2021

The purpose of this study was to identify the relationship between developing managers and managerial economics. This study examines the contributions of managerial economics to developing managers. Current study deals with a complete critical analysis of theoretical overview based on journals, books, and other sources. Managerial performance, skill, and effectiveness have been discussed in aspect of managerial economics. The bidirectional analysis proves that managerial performance creates economic efficiency and effectiveness. The major contributions of this analysis give the knowledge and way of developing a manager by supporting managerial economics. The stakeholder of this study can able to make a bridge between management and managerial economics.
Corporate governance perspective on enterprise risk management and organizational sustainability
Authors: Ugoani John Nkeobuna Nnah
Published: August 2021

The study was designed to explore the relationship between enterprise risk management and organizational sustainability. Enterprises can only meet the generational intention of founders when they are properly managed exemplified by sustainable performance. Business failures in recent history refocused attention towards good enterprise risk management to promote organizational sustainability. Sustainability implies meeting the needs of the present generation without compromising the needs of the future generations, and this cannot happen in an environment drenched in weak enterprise risk management. Corporate governance perspective suggests that the BODs of a company has the ultimate responsibility to establish effective risk management framework for the healthy performance and sustainability of the enterprise. Therefore, a major concern of the BODs is to diversify away risks and to create a stable average to enhance organizational performance.  Management decision making as an integral part of modern management aims at both enterprise risk minimization and the optimal achievement of organizational goals and sustainability. The exploratory research design was used for the study. Data generated and analyzed through statistical techniques, showed strong positive relationship between enterprise risk management and organizational sustainability. Because of limitations in terms of current literature, the study was not exhaustive; therefore, further study should examine the relationship between weak risk management and enterprise failure. It was recommended that complex organizations must establish good corporate governance structure to promote enterprise risk management and organizational sustainability.
Health and safety (hs) risks normalization in the construction industry: the SMEs perspective
Authors: Adegboyega Adesoji Anthony , Eze Chidiebere Emmanuel , Sofolahan Onyinye
Published: August 2021

The construction industry is hazardous and experiences poor health and safety performance records; as a result of the abuse and negligence of health and safety policies. Emphasis is now on health and safety management as health and safety risks are now normalised in the construction industry by the actions of construction SMEs. The study assessed the factors promoting health and safety risks normalisation in the construction industry of Nigeria. The study sampled construction professionals and tradespeople, using a well-structured questionnaire and snowball sampling techniques. With a response rate of 72.61% and a Cronbach's alpha value of 0.916; percentage, frequency, Mann-Whitney U Test and factor analysis were used to analyse the gathered data. It was found that there is a low level of occupational health and safety policies application and performance in the construction industry. The poor health and safety performance is prompted by HS risks normalisation promoted by factors such as misconception of and unwillingness to invest in HS, informal and unstructured HS policies, medical issues and excessive workload, Planning and client unwillingness, management commitment issues, and unorganised HS culture. Also, there was no statistically significant difference in the perceptions of the professionals and the tradespeople regarding 89.29% of the assessed variables. Commitment from the management and leadership of the SMEs and making of health and safety culture an integral part of the functioning of the organisations was thus recommended.
The influence of the governance and innovation indexes on the environmental performance of countries
Authors: De Miranda Ronaldo Leão , Lange Alberto Augusto , Kroenke Adriana , Parisotto Iara Regina dos Santos
Published: August 2021

In a period marked by ascending international independence and integration, governance and innovation are considered important tools in the sustainable growing process of countries, highlighting a constant search for positive development. The present paper intends to analyze the influence of the innovation and governance indexes on the environmental performance of nations around the globe. This is a descriptive study, we chose a quantitative approach and the data were collected on the Worldwide Governance Indicators (2018), Global Innovation Index (2018) and Environmental Performance Index (2018) websites. Subsequently, the data were organized and tabulated on the software SPSS®, version 22. Our analysis happened with the aid of descriptive statistics and linear regression. The main results indicate that countries do not show better environmental performance - where we take environmental health and the vitality of the ecosystems into consideration - due to the confidence and respect to the process in which governments are elected and observed.  In the innovation perspective and context, we could infer that it influences the environmental performance among the 108 countries that compose the sample. Therefore, the opinion regarding the importance of innovation is essential to comprehend the development of countries, and that includes the environmental field.
Thrombospondin domain1-related congenital chylothorax in an infant with maple syrup urine disease: a challenging case
Authors: Al Mandhari Hilal , Al Naamany Nidaa , Ur Rahman Asad , Al-Kindy Hussain , Naz Qureshi Tabinda , Al-Thihli Khalid
Published: August 2021

Objectives

Congenital chylothorax is a rare entity with various etiologies ranging from anatomical to genetic causes. If associated with non-immune hydrops fetalis mortality rates can reach up to 98%. Treatment is challenging and mostly supportive, with no standard guidelines.

Case presentation

We describe the unique and challenging course of a late preterm infant with non-immune hydrops fetalis (NIHF), and recurrent chylothorax attributed to homozygous mutations in thrombospondin domain1 (THSD1) gene. The infant was also affected with maple syrup urine disease (MSUD), which further complicated the clinical course. Treatment was supportive by means of chest tubes, intubation, mechanical ventilation, and eventually he was tracheostomized and discharged home on home BiPAP ventilation and required prolonged use of octreotide to prevent re-accumulation of chylothorax.

Conclusions

THSD1 gene has a role in vascular permeability and its mutation in our patient caused congenital chylothorax and NIHF and is also associated with other features such as vascular malformations.