bluuebunny/crossref_metadata_2025 huggingface dataset:
Protective effect of Helichrysum plicatum on head shock protein inflammation and apoptosis in Gentamicin induced nephrotoxicity
Authors: Bolat Ismail , Terim–Kapakin Kubra Asena , Apaydin Yildirim Betul , Manavoğlu Kirman Esra
Published: August 2024

Gentamicin (GM) is an aminoglycoside antibiotic the most common used in the treatment of infectious diseases in humans and animals. However, GM causes damage to many tissues and organs in the body, especially the kidneys. Helichrysum plicatum (Hp), native to the Balkans and Anatolia, is a plant used in various diseases such as diabetes, liver and kidney damage. In this study, Male Spraque Dawley rats (n=36 and 200–250 g) were randomly divided into 6 experimental groups: Group 1: Control; received normal saline (intraperitoneally –i.p.–), Group 2: Hp (100 mg·kg–1 day i.p.), Group 3: Hp (200 mg·kg–1 day i.p.), Group 4: GM (80 mg·kg–1 day i.p.), Group 5: GM 80 + Hp 100 (mg·kg–1 day i.p.), and Group 6: GM 80 + Hp 200 (mg·kg–1 day i.p.). Then kidney tissue samples were collected for evaluations. All of our results showed that Hp (100 mg·kg–1 day) reduced the levels of pro–inflammatory cytokines such as IL–8, IL–6, and TNF– while increasing the level of anti–inflammatory cytokine IL–10. It was also observed that Hp reduced the expressions of the caspase3, NOS and Heat shock proteins such as Hsp27 and Hsp70. With this study, we have shown that Hp probably due to its chemical properties has a protective effect against GM induced nephrototoxicity by reducing the values stated above to normal values.
Evaluation of the uterine wall echotexture changes following an induced abortion in mid–term pregnant bitches: preliminary study
Authors: Bal Yelda , Alaçam Erol , Aslan Selim , Kaya Duygu , Mülazimoğlu Serkan Barış , Ay Serhan Serhat , Schäfer–Somi Sabine
Published: August 2024

The objective of this study was to evaluate structural echotexture changes in the uterine wall following abortion induction in bitches during the late embryonic/mid–gestation stage and to develop an evaluation method for the abortion process. A total of 10 healthy pregnant bitches of different breeds, ranging from 25 to 40 days (d) of gestation, were included in this study. In Group 1 (n=5), Aglepristone (10 mg·kg-1 bw, sc) was administered once daily for two consecutive d. In Group 2 (n=5), a combination of Aglepristone, Cabergoline, and Misoprostol was used for induction of abortion (IA). Prior to the induction of abortion, and at 24–hour intervals until completion of abortion (CA), the uterus and placenta were sonographically examined. Additional examinations were conducted on d 1 (CA+1), d 7 (CA+7), and d 14 (CA+14) after the abortion process was completed. Blood samples were taken on the same days to detect serum progesterone (P4) levels. Selected echotexture parameters (homogeneity, contrast, gradient, and entropy) were assessed on sonographical images using image analysis software (Bs200Pro®). Contrast and gradient values significantly decreased on d CA, CA+1 and CA+7 compared to the IA state (P<0.05 and P<0.01). Contrast values were lower in G1 than G2 two days before abortion (CA–2) (P<0.01). Gradient levels were higher in G2 than in G1 on CA–2 (P<0.01). Homogeneity values of G2 were higher than in G1 on d CA–1 and CA+7 (P<0.05). Progesterone values showed a non–significant decrease after IA during the study period in both groups. In G2, a negative correlation between P4 and homogeneity (r=-0.797) and a positive correlation between P4 and contrast values (r=0.719) were found. In conclusion, echotexture analysis allows quantitative and objective evaluation of the uterine structure during abortion, but specific standard values need to be established for both medication protocols, taking into account individual factors.
Evaluation of the effect of local Bovine Amniotic Fluid on Osseointegration of Titanium Implants: A Histologic and Histomorphometric Study
Authors: Istek Ozmen , Tanrisever Murat , Atille Aydin Melek , Pak Pınar , Eroksuz Hatice , Karabulut Burak , Ekinci Elif , Dundar Serkan
Published: August 2024

The aim of this study was to histologically and histomorphometrically investigate the effect of locally applied bovine amniotic fluid (BAF) on osseointegration levels in implants. Adult female Sprague–Dawley rats weighing 300–350 g were used as subjects. The rats were divided into two groups: the sham–operated control group (n=10) and the local BAF group (n=10). Implant cavities were created in the tibias of all subjects under sterile saline cooling with rotating instruments. Local BAF was applied to all implant sockets before the implants were placed. Rats were sacrificed after a four–week osseointegration period. Histological staining was performed using hematoxylin and eosin staining to analyze the osseointegration. Examinations of the bone implant connection (BIC) and peri–implant bone formation (PBF) were performed using a light microscope and an image analyzer. As a result of the analysis, the mean BIC value was 40.3 ± 4.9 for the sham–operated control group and 45.2 ± 7.7 for the local BAF group. The mean PBF was 39.9 ± 6.3 for the sham control group and 40.5 ± 5.7 for the local BAF group. A statistically significant difference was found between the sham control group and the local BAF group for the BIC and PBF values (P>0.05; P: 0.11; P: 0.83). The application of local BAF to the implant socket did not have a clear positive effect on implant osseointegration. More studies are needed to clarify the association between local BAF and osseointegration.
Penerapan Metode Proyek Untuk Meningkatkan Motivasi Belajar Pada Anak Usia 5-6 Tahun Di Raudhatul Athfal Lillah Kecamatan Tapung Kabupaten Kampar
Authors: Rayahu Evi , Nikmah Nikmah , Suliyani Iis
Published: August 2024

The purpose of this research was to obtain of the use of the project method in improving the early childhood aged 5-6 years sudents’ learning motivation through the project methods at RA Lillah. This research used classroom action research. The subjects in this study were 20 early childhood aged 5-6 years sudents, 9 boys and 11 girls. The resuls of the research proved that the early childhood aged 5-6 years sudents’ learning motivation at RA Lillah Tapung Kampar was low at 52.19% most of them got “poor” category at 51%-60%. After the implementation of the project method the early childhood aged 5-6 years sudents’ learning motivation improved in each Cycle at meetings 1 and 2, Cycle I was 65.31% in “Fairy good” category in range of 56%-75%. at meetings 1 and 2 of cycle II it was 84.68% in “good” category in range of 76%-100%. By the improvement of the early childhood aged 5-6 years sudents’ learning motivation each cycle I and II showed that this project method was effective to increase sudents’ learning motivation. The recommendation for the next researchers is expected to use other learning methods that are better and more effective and can also develop broader indicators of learning motivation so that the results can be better
Penggunaan Media Pohon Angka Untuk Meningkatkan Kemampuan Mengenal Konsep Bilangan Pada Anak Kelompok B TK Mutiara Kecamatan Siak Hulu Kabupaten Kampar
Authors: Amin Muhammad , Rahayu Evi , Guswanti Nelia
Published: August 2024

This research was conducted in two cycles and each cycle was conducted in two meetings. In order to ensure this classroom action researchrun well, the researcher arranges the stages: 1) Action planning/preparation, 2) Action implementation, 3) Observation, and 4) Reflection. The subjects in this study were 14 students of B1 class consist of 8 girls and 6 boys in the first semester of the 2021/2022 academic year at TK Mutiara Kindergarten, Siak Hulu, Kampar. Meanwhile , the object of this research was the use of number tree media to improve the ability to recognize the concept of numbers of early childhood students . The research data were collected through teacher observation techniques and early childhood students' activities and documentation. After the data was collected through observation, the data was processed using the percentage form. The results of this study are there is an increasing in the learning process carried out by the teacher and the early childhood students' ability to recognize the concept of numbers. Observation of children's activities also increased, this can be seen from the pre action’s data to cycle II meeting 2. Initial data was 43.62%, Cycle II meeting 2 obtained  84.69%. So that the overall increase in early childhood students' activities to recognize the concept of numbers obtained 41.07%.
Penerapan Metode Berbicara Tentang Hewan Terhadap Perkembangan Sosial Emosional Anak Usia Dini Di PAUD Nurul Hikmah Desa Tanjung Harapan Kecamatan Kampar Kiri Kabupaten Kampar
Authors: Inmaryanto Inmaryanto , Nikmah Nikmah , Andani Winda
Published: August 2024

This study aims to determine the application of the method of talking about animals to the socio-emotional development of early childhood in PAUD Nurul Hikmah Tanjung Harapan Village, Kampar Kiri District, Kampar Regency. This type of research is classroom action research (CAR). The results showed that the results of observing children's gross motor activity increased after using clogs as a game to motivate children's gross motor skills in students at Mutiara Kindergarten. This can be seen from the initial data to cycle II meeting 2. Initial data 43.83%, Cycle II meeting 2 obtained an average percentage of 86.36%. So that the overall increase in teacher activity obtained an average percentage of 42.53%
Penerapan Metode Bernyanyi Untuk Meningkatkan Religiusitas Anak Usia Dini Di TK Al Hikmah Pasir Putih Siak Hulu
Authors: Saputra Waldi , Ramadhan Syahri , Sulistiani Sulistiani
Published: August 2024

This research purposes was to find out the increasing of the early childhood students’ religiosity through singing method at TK Al-Hikmah Pasir Putih Siak Hulu. The research was classroom action research which was conducted in two cycles and each cycle in two meetings. To ensure the research conducted well, the researcher used certain steps;  1) Action planning, 2) Action implementation, 3) Observation, and 4) Reflection. The subjects in this research were 15 the early childhood students at class B1 TK Al-Hikmah Pasir Putih Siak Hulu in 2020-2021 academic year. While the object of this research was application of the singing method to increase religiosity at TK Al-Hikmah Pasir Putih. The data collection techniques were observation and presented in percentage forms.
             The research results were there was an improving the early childhood students’ religiosity before and after the action was taken to cycle I and from cycle I to cycle II.  Before the actions 4 or 26.67% the early childhood students were classified in undeveloped category. in the first cycle of the second meeting and in the second cycle of the second meeting, no early childhood students or 0% was classified in undeveloped category.  Before the actions 5 or 33.33 % the early childhood students were classified in developed category. In the first cycle of the second meeting there were 2 early childhood students or 13.33 % were classified in developed category. in the second cycle of the second meeting, there were 0 the early childhood students or 0% was classified in developed category. Before the action there were 6 the early childhood students or 40.00% were classified in well developed category. in the first cycle of the second meeting there were 5 the early childhood students or 33.33%, and in the second cycle of the second meeting, there were 3 the early childhood students or 20% were classified in well developed category. in the first cycle of the second meeting there was an increase of the early childhood students’ religiosity at 53.33%, the second cycle of the second meeting there was an increase in 80 %. It proved that singing method improved the early childhood students’ religiosity at TK Al-Hikmah Pasir Putih Siak Hulu.
Efektivitas Meronce Rainbow Palapah Batiak Terhadap Perkembangan Motorik Halus Di Taman Kanak-Kanak
Authors: Asha Linna Octri , Ismet Syahrul
Published: August 2024

This study aims to determine the effectiveness of the meronce rainbow palapah batiak activity on fine motor development in the Pembina State Kindergarten, Pasaman District, West Pasaman Regency. The sample of this research was 30 children in groups B1 and B2 of the Public Kindergarten of Pasaman District, consisting of 15 children in the experimental class and 15 children in the control class. This study uses a quasi-experimental design with a pre-test and post-test control group. In this study the data collection techniques in the form of experiments and observations. Then test the quality of the research instrument with a validation test with professional judgment and process the results of the instrument data using SPSS version 22.0 using the Alpha Crombach technique. While testing the hypothesis using the statistical T-test technique with the help of SPSS version 22.0 which shows a significant level of 0.148. It can be concluded that the meronce rainbow palapah batik activity is effective on fine motor development in the Pembina State Kindergarten, Pasaman District, West Pasaman Regency
Peran Orang Tua Dalam Membatasi Penggunaan Gadget Pada Raudhatul Athfal Islamiyah Al-Amin
Authors: Nunzairina Nunzairina , Nayla Zaskia Siregar Fatimah , Afifah Zahra
Published: August 2024

Research that has observed children, there are children who are addicted to gadgets resulting in children being private and happy to be alone. The role of parents who build his enthusiasm to see the outside world again. Whatever the case, children can be happy, and for traditional play equipment it might be more fun. From here interviewing parents can be done to get to know the child better. Long-term or short-term complex, children will get bored with their gadgets more and more. With the existence of gadgets, everyone is always very quick to retrieve information, but there is a lot that can affect all children. One step for today's children who are not directly related to flat objects/handphone. Parents have given gadgets to their children, with the excuse that they are not fussy. And the observations that have been purely carried out by researchers make awareness, the need for children not to understand gadgets from childhood. There are many cases of children who are already familiar with gadgets, and have a negative impact on them. Thurs children must be monitored continuously using gadgets
Evaluación del desarrollo comunicativo en niños con alteraciones neuromotoras: uso de un cuestionario para padres
Authors: Mora Carolina , Maggiolo Mariangela , Aguilera Loreto , Gana Cristián
Published: August 2024

Los cuestionarios dirigidos a los padres son instrumentos que se utilizan con frecuencia en la evaluación de la comunicación en niños muy pequeños. En este trabajo se presentan los resultados de aplicación de un cuestionario de este tipo en un grupo de madres de niños con trastornos neuromotores. Los resultados evidencian diferencias significativas entre las respuestas de las madres de niños según la edad de ellos y también diferencias significativas entre las respuestas dadas por madres de niños con desarrollo normal del lenguaje. Se estudia además la correlación entre los resultados del cuestionario y la evaluación directa de la comunicación de los niños del estudio realizada por los especialistas. Se discuten los resultados a la luz de las características de los niños, aspectos del instrumento y su proyección clínica en la evaluación de niños pequeños.
Bases neurológicas del lenguaje hablado y signado
Authors: Herrera Valeria
Published: August 2024

El estudio de los lenguajes de signos, ha permitido ampliar la comprensión del sistema neuronal que subyace al lenguaje. El presente artículo tiene por objeto desarrollar una revisión de la literatura, respecto de las relaciones entre las regiones cerebrales implicadas en la comprensión y producción del lenguaje de signos en comparación con el lenguaje oral. En esta revisión, se presentan los estudios que distintos grupos de investigación, a nivel mundial, han desarrollado para explorar las complejas relaciones entre lenguaje y cerebro.
Investigación, evaluación y colaboración profesional ante las dificultades del lenguaje. El reto hacia los modelos inclusivos
Authors: Acosta Victor
Published: August 2024

El trabajo fonoaudiológico en contextos educativos necesita algunos cambios urgentes con el fin de alcanzar un doble objetivo. En primer lugar, optimizar el lenguaje de todos los escolares, especialmente de aquellos alumnos de riesgo, con el fin de disminuir el impacto sobre el desarrollo, en general, y sobre el aprendizaje, en particular. En segundo lugar, mejorar los procesos de apoyo a la escuela y a la fami-lia, cambiándose la cultura organizativa basada en el trabajo de especialistas por otra sustentada en la colegialidad y la colaboración educativa. La incorporación de métodos cualitativos de investigación, la introducción de modelos integrados de evaluación (ecológica, cualitativa y dinámica) y la incorporación de parámetros ligados a modelos educativos inclusivos son algunos de los pilares fundamentales para iniciar y sostener el cambio.
Comprensión de la pantomima en pacientes afásicos
Authors: González Rafael , Helo Andrea , Toledo Lilian , Bevilacqua Jorge , Donoso Archibaldo
Published: August 2024

Los afásicos presentan alteraciones en la comprensión de la pantomima, sin embargo, existe contro-versia sobre si su causa es de tipo simbólica o práxica. Este estudio compara el rendimiento en la Pauta Exploratoria de Comprensión de la Pantomima (PECP) en un grupo de afásicos y un grupo control, se analiza el tipo de error cometido y las variables que influyen en sus rendimientos. Los resultados indican que los afásicos rinden significativamente menos que los normales, el error más frecuente en ambos grupos es el de relación semántica. Las variables que influyen en el rendimiento son: deterioro intelectual, severidad de la afasia y presencia de anosognosia. El estudio muestra evidencia que apoya al déficit del componente simbólico para explicar el déficit en la comprensión de la pantomima en los afásicos.
Aprendizaje basado en problemas: un enfoque innovador en el currículo de fonoaudiología
Authors: Villanueva Pía
Published: August 2024

El aprendizaje basado en problemas (ABP) surgió hace 20 años como respuesta al sistema de educación basado en clases magistrales o en casos clínicos. El uso de ABP es cada vez más frecuente en la enseñanza de profesiones de la salud y otras disciplinas. Se realiza una introducción al Progra-ma de ABP, la descripción y evaluación de su aplicación en la División de Ciencia de la Audición y el Lenguaje de la Universidad de Hong Kong al currículo de pre grado de Fonoaudiología. Se discute el desarrollo y puesta en marcha del plan, importancia del trabajo independiente, rol del tutor, del gru-po y una integración entre objetivos, problemas y evaluaciones. Se comenta la utilidad del ABP y su eventual implementación en el programa de la Escuela de Fonoaudiología de la Universidad de Chile
Social Pedagogy in the 21st Century – in Search of Identity and Meta-Scientific Dimensions
Authors:   Sofia University, Tcholakova Maya
Published: August 2024

The article presents main trends in the development of social pedagogy as a science, academic discipline, specialty and practice in the first decades of the 21st century. Distinctive in the process of self-determination of social pedagogy is the clarification of its relationship with social work in all its manifestations. The theoretical study emphasizes the conceptualizations of social pedagogy in the UK,
New Guidelines for School Counselors in their Fight Against Cyberbullying Prevention in Schools
Authors:   Sofia University, Dikova Ina
Published: August 2024

In recent decades, cyberbullying, also known as “online bullying” or “electronic violence”, has developed as a serious social problem for society, and more specifically for the school, as a microcosm of society. Amongst all school personnel, it is the school counselor who has the highest responsibility in helping students develop all the necessary skills to avoid this relatively new form of bullying, or at worst, to cope with it. However, finding the right way to do this is not always easy, which explains the inaction on the part of adults at school and the resulting reluctance of students to seek help. The purpose of the article is to fill this gap by highlighting the existing misconceptions and intervention efforts that prevent school counselors from effectively dealing with the problem and, accordingly, to propose a new philosophy with fresh approaches and guidelines that facilitate their fight against cyberbullying.
Levels of Self-Educational Activity of Students of Humanitarian Faculties of the University
Authors:   V.O. Sukhomlynskyi National University of Mykolaiv – Mykolaiv, Sereda Iryna , Stelmah Nina
Published: August 2024

The research at the Mykolaiv V. Sykhomlynskyi National University provided diagnostics of levels of self-educational activity of students of humanities faculties. It has been determined that self-education activity actualizes the subjective characteristics of future specialists: level of self-awareness, professional motivation, self-regulation, self-realization. Analysis of diagnostic results of 593 students revealed a predominantly low level of self-education activity. The theoretical and empirical research made it possible to predict its growth in the traditional educational process in the conditions of activation of students’ self-education. The results of the study can be applied in the process of psychological and pedagogical support of students.
The Science of Upbringing, Training and Education – Historical Review, Etymological Research and Interpretation of Pedagogical Concepts
Authors:   National Military University, Petrova Elitsa
Published: August 2024

In the article, the author tries to provide the reader a view on the science of upbringing, training and education, scientifically based and supported by a number of scientific evidence. The overview of pedagogy and its main building blocks – upbringing, training and education was carried out through a number of authoritative Anglo-Saxon dictionaries and scientific sources, incl. Online Etymology Dictionary, Cambridge Dictionary, Merriam-Webster Dictionary, Encyclopaedia of Higher Education, Routledge Encyclopedia of Philosophy, Internet Encyclopedia of Philosophy, Foundations of Philosophy, New International Encyclopedia of New York, etc. A brief historical review of the pedagogical idea from ancient times to the present day is made, and in conclusion the described pedagogical schools and concepts are separated into educational directions.
Empowering the Children through the Eyes of Humanitarian Professionals
Authors: Kaneva Ophelia
Published: August 2024

According to the United Nations Convention on the Rights of the Child, children should be supported and empowered to express their opinion about their future, lifestyle, and everything related to their existence. This is especially important when kids are in foster care, because they are at a disadvantage. So, the understanding about their empowerment in the decision-making process should be part of the professional qualification, training, rehabilitation, support (as well) at horizontal and hierarchical level for humanitarian professionals. That is why focus groups were organized and held in different geographical regions in Bulgaria during 2021 – 2022, with professionals that are taking care of children with disabilities, abandoned children, gifted children and other children's groups with the aim to understand how professionals understand the process and the right of the child to participate in the decision-making process when part of the social care system.
Analysis of the Results of a Research Conducted on the Music Literacy of Students – Future Teachers
Authors: Dimitrova Ralitsa
Published: August 2024

This article presents results of the musical notation skills of current students – future music teachers. The research was conducted at the beginning of the 2022/2023 and 2023/2024 academic year with students from Sofia University “St. Kliment Ohridskiˮ, Faculty of Educational Sciences and Arts, major “Elementary School Pedagogy and Foreign Languageˮ before studying Didactics of music. The bachelor’s degree provides the acquisition of a teacher’s license after successful completion of the four-year course of study. The diploma of the future pedagogues gives the opportunity to teach the subject of Music in the initial stage of the secondary (general) school. For practical purposes, the study was carried out before the start of the lecture course on the Didactics of Music.
Formation of Text Creation Skills in Students at Primary Level of Education
Authors: Raykova Irena
Published: August 2024

The article presents the results of a research carried out with students at primary level of education. The object of the research is the education of mother tongue. The subject is the process of formation and development of students’ skills to retell a story and text creation. Approbation of the suggested graphical models is realized through the Neurographica method. Graphical models are used in Bulgarian language and literature lessons. Students draw models of the narrative, before writing the text. As a result, they have visual support when creating the text. Analysis of the data shows various benefits of using graphical models for development of students’ communicative speech competence. The results of the study show a significant improvement of students’ writing skills. Among the skills which students improve best, are: to retell the episodes of the story in their chronological order, to build a coherent composition of the text and logical connection between the sentences, better graphical design of the text, etc.
Transformações da paisagem urbana: impactos da urbanização nas áreas verdes de Manaus-AM
Authors: Santos Elizabeth dos , Souza Vinicius Souza e , Silva Carliza Luz da , Costa Mônica Suani Barbosa da , Dutra Jurandir Moura , Pereira Cloves Farias , Silva Suzy Cristina Pedroza da
Published: August 2024

O mapeamento do uso e ocupação do solo desempenha um papel importante na compreensão da organização e das mudanças espaciais no ambiente, isso é possibilitado pelos crescentes avanços geotecnológicos. O objetivo desta pesquisa foi identificar a estrutura da paisagem em áreas urbanizadas na zona urbana de Manaus, no Amazonas. Para a análise utilizou-se o método quantitativo e ferramentas do geoprocessamento. Foram processadas imagens de Landsat de 2015 e 2023, corrigidas geometricamente e classificadas com  a ferramenta Dzetsaka e pelo algoritmo gaussiano, e métricas de paisagem com a ferramenta Landscape Ecology Statistics. A análise das imagens revelou mudanças significativas na cobertura do solo e na paisagem urbana de Manaus ao longo dos últimos anos, impulsionadas pela expansão da Zona Franca de Manaus e do aumento populacional. A falta de um planejamento urbano eficaz resultou em um aumento de ocupações irregulares com a destruição da cobertura vegetal e da ocorrência de problemas ambientais, como poluição e infraestrutura precária. Portanto, a integração de métricas de paisagem pode fornecer insights para orientar o planejamento urbano e a conservação da biodiversidade.
Monte-Carlo SHALSTAB: uma abordagem probabilística para avaliação espacial de movimentos gravitacionais de massa
Authors: Guerra Guaragna Gabriel , Augusto dos Reis Higashi Rafael , Cid Bastos Rogério , Deeke Viek Thiago
Published: August 2024

Este artigo apresenta uma abordagem probabilística para a avaliação da estabilidade de encostas. O método utiliza o modelo matemático SHALSTAB como base determinística, para levar em consideração incertezas, aplica o método Monte-Carlo em conjunto com funções densidade de probabilidade (PDF). A utilização de valores médios é prática convencional na modelagem determinística, estas modelagens consideram os eventos e variáveis únicos, desconsiderando a aleatoriedade. O método Monte Carlo se apoia na lei dos grandes números, tendendo à espectância após diversas simulações. Foram executadas 100.000 simulações SHALSTAB, variando os parâmetros geotécnicos dos solos. Após cada iteração, as saídas SHALSTAB foram padronizadas utilizando uma função de distribuição cumulativa (CDF) da precipitação na área de estudo, possibilitando a geração do mapa probabilístico final. Como resultado, a área abaixo da curva ROC (AUC) foi de 0,893 e, como a padronização se deu via precipitações regionais, fez-se possível a reverter o mapeamento probabilístico traduzindo-o para precipitação crítica necessária para a desestabilização das encostas.
Metallurgical study of manganese lump ores from Minas Gerais, Brazil
Authors: Câmara Nogueira Francielle , Baldessin Costa Adriana , Guedes Cota Tiany , Malena Fernandes Lima Rosa , Linhares Reis Érica , Mota de Lima Hernani
Published: August 2024

Este estudo investiga a correlação entre o tipo e a qualidade do minério de manganês na fração lump ore ( - 19,0 + 6,3 mm) e seu comportamento metalúrgico de amostras provenientes de duas minas localizadas em Minas Gerais, Brasil. Foram realizadas caracterizações física, química e mineralógica, além de testes metalúrgicos como tamboramento e decrepitação, nas amostras denomidas GPN (Penedo) e GTT (Totonho). Observou-se variação nos teores de manganês, ferro e silica, com altos valores de sílica indicando potencial para a produção de SiMn. As principais fases cristalinas identificadas foram espessartita, todorokita, pirolusita, criptomelana, quartzo, dolomita e goethita. Os testes de tamboramento e decrepitação mostraram uma tendência para a geração de finos, especialmente na fração - 6,3 mm, devido à alta porosidade e à presença de minerais hidratados. Os índices de decrepitação foram menores para amostras secas ou tratadas termicamente, com reduções de 31% para GTT e 43% para GPN quando secas a 105°C. Os resultados de decrepitação destacaram o impacto significativo da umidade na geração de finos.
Métodos moleculares na caracterização da disbiose intestinal associado ao diabetes mellitus tipo 2
Authors: Cavalcanti Tárcio Marcos Lins , Calado Filho Ivaldo , Messias Inalda Maria de Oliveira , Messias Júlio Brando
Published: August 2024

Alteração na diversidade, quantidade ou densidade de microorganismo pode levar a uma desregulação do trato intestinal e consequentemente à disbiose. O objetivo foi identificar quais os métodos e marcadores moleculares utilizados para diagnóstico da disbiose. Trata-se de uma revisão integrativa da literatura nas bases de dados PubMed/MEDLINE, LILACS. Foram incluídos artigos dos últimos 15 anos que respondessem à questão norteadora: “Quais os principais métodos moleculares relacionados à disbiose intestinal associado ao diabetes mellitus tipo 2?”. Nove artigos foram incluídos, destacando a técnica de PCR e o fator microbiano, 16S rRNA. Conclui-se que o microbioma intestinal e a genética do hospedeiro podem influenciar os fenótipos metabólitos. As interações anormais entre o microbioma e o sistema imunológico em pessoas geneticamente suscetíveis podem causar doenças imunomediadas complexas. Em seres humanos, o uso de prebióticos e/ou probióticos pode auxiliar no controle de doenças metabólicas associadas à obesidade. Amostras amplificadas por PCR da região 16S rRNA emergem como método alvo terapêutico eficaz e possível marcador preditivo no diagnóstico da disbiose.
Antimicrobial packaging based on molecular docking of natural products
Authors: Santos Lorena Limao Vieira dos , Barbosa Jhonatas Rodrigues , Costa Renato Araújo da , Henriques Lourenço Lúcia de Fátima
Published: August 2024

For a long time, studies on food packaging focused on antimicrobial agents, without, however, explaining the mechanisms. Therefore, in this analysis and opinion text, we approach the promising scenario, regarding the use of molecular docking techniques in the development of antimicrobial packaging. Molecular docking was identified as an important guidance tool, showing researchers which molecules had effective antimicrobial activity and their mechanisms. Furthermore, based on molecular docking studies, researchers were able to optimize in vitro and in vivo antimicrobial experiments. The targeted approach was efficient in developing antimicrobial packaging, which increased the shelf life of several foods. We consider molecular docking an indispensable tool for studies on antimicrobial packaging and a promising field of research.
Keywords: Molecular docking; Food packaging; Antimicrobial potential; Shelf life; Molecular docking.
Durante muito tempo, os estudos sobre embalagens de alimentos focaram-se nos agentes antimicrobianos, sem, no entanto, explicar os mecanismos. Portanto, neste texto de análise e opinião, abordamos o cenário promissor, no que diz respeito à utilização de técnicas de docking molecular no desenvolvimento de embalagens antimicrobianas. O docking molecular foi identificado como uma importante ferramenta de orientação, mostrando aos pesquisadores quais moléculas tinham atividade antimicrobiana eficaz e seus mecanismos. Além disso, com base em estudos de acoplamento molecular, os pesquisadores conseguiram otimizar experimentos antimicrobianos in vitro e in vivo. A abordagem direcionada foi eficiente no desenvolvimento de embalagens antimicrobianas, o que aumentou a vida útil de diversos alimentos. Consideramos o docking molecular uma ferramenta indispensável para estudos sobre embalagens antimicrobianas e um campo de pesquisa promissor.
Palavras-chave: Docagem molecular; Embalagem de alimentos; Potencial antimicrobiano; Vida útil; Acoplamento molecular.
Síndrome coronariana aguda em pacientes jovens: revisão de literatura
Authors: Felipe Alonso Matheus , Kuranishi Maria Eduarda , Tatiara Martins de Medeiros Caylani , Ribeiro Soares Borges Larissa , Peripolli da Silva Maria Eduarda , Vieira Donzelli Renato , Cruz Meirelles Izadora , Russo Milan Nycollas , Grippa Sant'Ana Paula
Published: August 2024

As doenças cardiovasculares (DCVs) são a principal causa de morte no Brasil, com a síndrome coronariana aguda (SCA) sendo uma das mais graves. Apesar da redução das taxas de mortalidade, a incidência entre jovens está aumentando, impactando significativamente na qualidade de vida e na saúde pública. Com isso, o bjetivo desse estudo foi realizar uma revisão da literatura sobre alguns aspectos clínicos e epidemiológicos da SCA em pacientes com idade até 50 anos, por meio da busca em bases de dados. Os estudos demonstraram que a síndrome coronariana aguda (SCA) em jovens é marcada por fatores de risco como dislipidemia e obesidade, sintomas atípicos e menores taxas de mortalidade hospitalar. Apesar disso, há desafios na detecção e manejo, e marcadores como hiper-homocisteinemia e lipoproteína (a) são relevantes para a gravidade e rastreamento. Além disso, falhas na prevenção e aumento de comorbidades, como diabetes, exigem estratégias de identificação precoce e manejo intensivo para reduzir morbidade e custos de saúde.
Self-reported prolonged standing work is not associated with lower back and lower extremity pain in viticulture workers
Authors: Almeida Pina Ana Karolina , Locks Francisco , Marques Ferraz Zalane Cristina , Alves de Brito Camila , Brusaca Luiz Augusto , De Amorim Batista Gabriel , Trombini-Souza Francis , Fulgêncio Alves da Silva Tarcísio , Cappato de Araújo Rodrigo , De Oliveira Ana Beatriz
Published: August 2024

This cross-sectional study investigated the association between prolonged standing at work and pain in the lower back and lower limbs in viticulture workers. Prolonged standing was self-reported. Lower back and lower extremity pain were obtained using a 0-10 scale and categorized as “present” and “absent.” The association between standing work and the presence of pain was tested using binary logistic regression. 320 viticulture workers were evaluated. Participants were mainly female (78.4%), with a mean age of 36.2 (±9.1) years, 83.1% worked in the field, and 16.9% in packaging. The prevalence of pain was 50.3% for the lower back, 18.1% for the hip, 20.9% for the knee, and 24.4% for the ankle/foot. Logistic regression showed a negative association between dynamic standing at work and high-intensity pain in the lower back.
A importância da auditoria interna contábil para as micros e pequenas empresas
Authors: Oliveira Rosimeire , Ferreira Talita Salanova , Lima Juliane Nascimento de
Published: August 2024

A auditoria interna contábil revela-se uma ferramenta essencial para as Micros e Pequenas Empresas. Por proporcionar uma análise detalhada dos processos financeiros e operacionais, identificando pontos de melhoria e possíveis irregularidades. Através da auditoria interna contábil é possível assegurar a veracidade das informações. O artigo tem como principal objetivo investigar a importância da auditoria interna contábil nas Micros e Pequenas Empresas. A pesquisa foi conduzida utilizando uma abordagem qualitativa, com uma revisão de literatura com as coletas de dados no período de 2003 a 2023, em websites, plataformas, perídocos da Capes, Scielo, google acadêmico e sites oficiais do governo. Foram analisados diversos artigos científicos, livros e normas relacionadas à auditoria interna e contabilidade para micro e pequenas empresas. Os resultados evidenciaram que a auditoria interna contábil melhora a eficiência operacional, reduz fraudes e erros, e proporciona uma base sólida para a tomada de decisões. Além disso, as empresas que adotam práticas de auditoria interna têm mais facilidade em obter crédito e atrair investimentos, devido à transparência e confiança geradas.
A terra tradicionalmente ocupada pelos povos indígenas e a compatibilidade com a tutela constitucional do meio ambiente
Authors: Rocha Alan Pierre Chaves
Published: August 2024

No presente artigo acadêmico discorremos a respeito das terras tradicionalmente ocupadas pelas comunidades indígenas, e a compatibilidade com a tutela constitucional do meio ambiente. Neste diapasão, pretendemos tencionar o direito à exploração das riquezas das terras tradicionalmente ocupadas e a efetiva proteção ao meio ambiente. Delimitamos, desde logo, a pesquisa promovendo o recorte no âmbito da exploração dos recursos minerais das reservas indígenas, e a tese firmada no tema 1.031 no Supremo Tribunal Federal-STF. Como hipótese, reconhecemos a necessidade de equilibrar a função social da propriedade com a efetiva proteção ao meio ambiente. A relevância da pesquisa reside na importância da temática no cenário econômico e na atualidade com base na decisão firmada no âmbito do Recurso Extraordinário-RE n. 1.017.365. A metodologia empregada na pesquisa foi descritiva, com abordagem qualitativa, a partir de análises bibliográfica e documental. Pretendemos, destarte, conduzir a pesquisa com a finalidade de produzir texto jurídico que contribua com a evolução do tema na comunidade acadêmica.
Antimicrobial resistance: A growing global threat
Authors: Alsamannoudi Hamza , Alamri Abdulaziz , Bawazeer Ahmad , Almotiri Tariq , Alharbi Sattam , Alshammari Delyal , Alnasser Bader , Alswayeh Hani
Published: August 2024

Antimicrobial resistance (AMR) has emerged as one of the most pressing public health challenges of the 21st century. The ability of microorganisms to develop resistance to antimicrobial drugs threatens to undermine the significant medical advances achieved over the past century. As resistance to existing antimicrobials continues to spread globally, there are growing concerns that we may be entering a "post-antibiotic era" where common infections and minor injuries can once again become deadly (World Health Organization, 2014). This study provides a comprehensive overview of the antimicrobial resistance crisis, exploring the underlying causes, the scope of the problem, its impact on human health and the economy, and potential solutions to address this global threat. The paper draws upon the latest scientific research and reports from leading health authorities to shed light on this critical issue.
Healthcare digitization and patient confidentiality
Authors: Alamri Abdulaziz , Bawazeer Ahmad , Almotiri Tariq , Alharbi Sattam , Alshammari Delyal , Alnasser Bader , Alswayeh Hani
Published: August 2024

The healthcare industry has undergone a significant transformation in recent years, driven by the rapid advancement of digital technologies. The digitization of healthcare, encompassing electronic health records (EHRs), telehealth, and various digital tools, has revolutionized the way healthcare services are delivered and managed. This digital transformation has the potential to improve patient outcomes, enhance care coordination, and increase the efficiency of healthcare systems. However, the digitization of healthcare also raises important concerns about patient confidentiality and data privacy. As healthcare organizations embrace digital technologies, they must navigate the delicate balance between leveraging the benefits of digitization and ensuring the protection of sensitive patient information. Patients entrust healthcare providers with their personal and medical data, and it is the responsibility of these organizations to safeguard this information effectively. The failure to do so can have severe consequences, including breaches of patient trust, legal repercussions, and potential harm to patient well-being. This study aims to explore the interplay between healthcare digitization and patient confidentiality, examining the key challenges, best practices, and emerging trends in this critical area.
impact of insulin on patient quality of life
Authors: Alamri Abdulaziz , Bawazeer Ahmad , Almotiri Tariq , Alharbi Sattam , Alshammari Delyal , Alnasser Bader , Alswayeh Hani , Alrasheedi Sari
Published: August 2024

Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels due to the body's inability to effectively produce or utilize the hormone insulin (American Diabetes Association, 2022). Insulin is a critical hormone produced by the pancreas that enables the body to regulate blood sugar levels by facilitating the uptake of glucose into cells for energy or storage (Wilcox, 2005). Without sufficient insulin production or function, blood glucose levels can become dangerously high, leading to a variety of serious health complications. There are two main types of diabetes, type 1 and type 2, which differ in their underlying causes and treatment approaches. Type 1 diabetes is an autoimmune disorder where the body mistakenly attacks and destroys the insulin-producing beta cells in the pancreas, resulting in an absolute insulin deficiency (Atkinson et al., 2014). Type 2 diabetes is typically associated with lifestyle factors such as obesity and physical inactivity, and is characterized by the body's reduced sensitivity and responsiveness to insulin, a condition known as insulin resistance (Kahn, 2014). Regardless of the type, diabetes requires careful management through lifestyle modifications and/or pharmaceutical interventions, including the administration of exogenous insulin,,,
Epileptic medications and improving patient outcomes
Authors: Alsamannoudi Hamza , Alamri Abdulaziz , Bawazeer Ahmad , Almotiri Tariq , Alharbi Sattam , Alshammari Delyal , Alnasser Bader , Alswayeh Hani , Alrasheedi Sari
Published: August 2024

Epilepsy is a chronic neurological disorder characterized by recurrent seizures, which are sudden and uncontrolled electrical disturbances in the brain. It is one of the most common neurological conditions, affecting approximately 50 million people worldwide (World Health Organization, 2019). Effective management of epilepsy is crucial, as uncontrolled seizures can lead to significant physical, psychological, and social consequences. The treatment of epilepsy primarily involves the use of antiepileptic drugs (AEDs), also known as anticonvulsants. These medications work by modulating the electrical activity in the brain, thereby reducing the occurrence and severity of seizures. Over the past several decades, research has focused on understanding the mechanisms of action, efficacy, and safety of various AEDs, as well as the factors that influence their clinical use. This study aims to provide a comprehensive review of the research literature on epileptic medications, covering key aspects such as: 1) The pharmacological mechanisms of action of AEDs; 2) The efficacy and safety profiles of established and newer AEDs; 3) Factors influencing the selection and use of AEDs, including patient characteristics, comorbidities, and drug interactions; 4) Emerging trends and future directions in the development and utilization of epileptic medications.
Pasar Uang dalam Tinjauan Perspektif Islam
Authors: Jaya Asri , Wahab Abdul , Lutfi Muhtar
Published: August 2024

Dalam bidang perbankan, pasar uang merupakan sarana transaksi antar bank yang kekurangan atau kelebihan likuiditas. Di pasar uang, aplikasi masih menggunakan bunga sebagai alat untuk menghasilkan keuntungan. Namun saat ini pasar uang sudah ada berdasarkan prinsip syariah, dan telah mendapat legalitas fatwa Dewan Syariah Nasional (DSN) No. 37 tentang pasar uang antar bank dengan prinsip syariah sebagai solusi bagi kedua belah pihak. perbedaan mendasar terletak pada mekanisme penerbitan dan sifat instrument itu sendiri, pada pasar konvensional, instrument yang diterbitkan adalah instrument utang yang dijual dengan diskon dan didasarkan pada perhitungan bunga, sedangkan pasar uang syariah mekanisme penerbitan dan sifat instrumennya berdasarkan prinsip-prinsip syariah.
Analisis Job Design dan Budaya Kerja Terhadap Kinerja Karyawan Pada Bank BTPN Cabang Bawakaraeng Makassar
Authors: Handayani Fitri , Seniorita Seniorita , Rizal Samsul , Abdullah Irwan
Published: August 2024

This study aims to determine: (1) the effect of job design on employee performance, (2) the influence of work culture on employee performance. This research method used is quantitative, this research is a study that collects data or information and states variabels that describe job design and work culture on employee performance. Woth a total sample of 80 responden taken from the entire population. The instrument used in this study was a questionnaire sheet. Management is carried out by means of the SPSS program comparison t test. The results of this study use several tests, one of which is the t test using the t test, one of which is the t test using the t test, with the t test it is known that the value of t count > t table, this indicates that the hypothesis is accepted. The conclusions of the results of this study indicate that: (1) there is a significant positive effect between job design on employee from the result of the test, there is it count 0.5480 > t table 1.990 (2) there is no significant positive influence between work culture on performance at the Bawakaraeng Branch Bank From the test result t count -1.787 < t table 1.990.
Pemahaman Masyarakat Terhadap Peraturan Perpajakan Terhadap Kepatuhan Wajib Pajak
Authors: Rahma Besse , Misnawiah Misnawiah , Rahayu Siti Rezky , Darmansyah Darmansyah
Published: August 2024

Penelitian ini bertujuan untuk menganalisis pemahaman masyarakat terhadap peraturan perpajakan mengenai kepatuhan wajib pajak. Penelitian ini termasuk studi literatur yang digunakan untuk mengetahui bagaimana pemahaman masyarakat tersebut terhadap peraturan perpajakan mengenai kepatuhan wajib pajak dalam kehidupan sehari-hari. Dalam Penelitian ini metodologi yang digunakan adalah metodologi komparatif karena para peneliti dapat melakukan perbandingan pendapat terkait pemahaman masyarakat terhadap peraturan perpajakan dalam kepatuhan wajib pajak. Hasil Penelitian ini menunjukkan bahwa kualitas pelayanan pajak, kepercayaan masyarakat terhadap pengelolaan pajak, dan pemahaman masyarakat terhadap peraturan perpajakan memiliki pengaruh yang signifikan terhadap kepatuhan wajib pajak. Selain itu, kepercayaan wajib pajak terhadap aparat pajak juga berdampak positif terhadap tingkat kepatuhan wajib pajak.