bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS KELAYAKAN USAHA PENGOLAHAN IKAN SALAI DI KELURAHAN AIR DINGIN KECAMATAN BUKIT RAYA KOTA PEKANBARU PROVINSI RIAU (Studi Kasus Pada Usaha Ikan Salai Sedap Bakat)
Authors: Eka Marlena  , Azharuddin M Amin
Published: January 2023

This study aims to analyze the characteristics of entrepreneurs and smoked fish business profile; availability, acquisition, and use of raw materials and supporting materials for smoked fish processing business; non-financial business feasibility and financial feasibility of smoked fish processing business; and the sensitivity of the smoked fish processing business. The method used in this research was a case study in the processing business of "Spiced Fish Bakat" in Air Dingin Village, Bukit Raya District, Pekanbaru City, Riau Province. This research was carried out for six months starting from January to June 2022. The respondents in this study were entrepreneurs and four workers. Data analysis was performed using quantitative and qualitative descriptive analysis (market and marketing aspects, technical aspects, environmental aspects, legal aspects, and management aspects, and financial aspects using four investment criteria (NPV, Net B/C, IRR, and Payback Period) and sensitivity analysis with the Switching Value approach. The results showed that the characteristics of entrepreneurs belong to the productive age with 46 years of age, 16 years of education (graduate) with 12 years of business experience, and 4 family members. Salai Sedap Bakat fish processing business is classified as a small-scale and household business and still uses traditional technology in the production process. Non-financial feasibility from market and marketing aspects, technical aspects, legal aspects, and management aspects of the salai fish business was feasible. The environmental aspect was not yet feasible because there is no provision for waste treatment from the by-products of smoked fish processing. Meanwhile, financially the Salai Sedap Bakat fish processing business is feasible to be continued and developed because it is profitable based on 4 investment criteria with an NPV of IDR 50,086,397 > 0, Net B/C with a value of 1.43 > 1, an IRR value of 21% > i ( 6.69%) and Payback Period for 4 years 1 month 5 days < business life (10 years). Based on sensitivity analysis using the switching value approach, the profit of the Salai Sedap Bakat Fish Business was more sensitive to the decline in the price of catfish production with a decrease in the NPV value of 90.65% and a decrease in the production of smoked catfish with a percentage of 90.28% compared with an increase in operational costs with a percentage of 82.36% of the base value.
PENGARUH PENGGUNAAN AIR KELAPA HYBRIDA (Cocos nucifera) DENGAN DOSIS YANG BERBEDA TERHADAP MASKULINISASI LARVA IKAN GUPPY (Poecilia reticulata)
Authors: Irvandu Putra Perdana  , Iskandar Johan  , Muhammad Hasby
Published: January 2023

The purpose of this study is to determine the effectiveness of using young coconut water as an alternative material for masculinizing guppy fish through different immersion times on guppy fish larvae. This research was carried out for 50 days starting from October 25 to December 14, 2020, at the Fish Seed Center (BBI) of the Islamic University of Riau Pekanbaru. The method in this study used a completely randomized design (CRD) method with five treatments and three replications. The treatments used were soaking time of 8 hours with doses using hybrid coconut water, namely: P0: without using coconut water, P1: 50 ml, P2: 100 ml, P3: 150 ml, and P4: 200 ml. The experimental treatments were carried out on guppy fish (Poecilia reticulata) larvae. The containers used were 15 units of jars with a capacity of 10 liters which was filled with treatment media with a stocking density of 15 fish/jar. Based on the results, it was found that the highest male sex direction in guppies was in treatment P4 with a dose of 200 ml with a soaking time of 8 hours with the number of males produced at 94% and the lowest was in treatment P0 without using a dose of young coconut water which was only produced 37% males with a very low survival rate. Analysis of variance showed that F count (2.59) < F table 0.05 (3.48) at the 95% accuracy level, where different doses of masculinization of guppies (Poecilia reticulata) were not significantly different. Climatic data in the form of temperature was 28-32 0C, pH 5-7 and DO 5,7-8,20 mg/l.
A study on changes in drought in Haiduong provinces of Vietnam in the context of climate change
Authors: Ha Nguyen Thi , Hung Dao Ngoc , Phuong Cu Thi
Published: January 2023

Hai Duong is a province in the Red River Delta of northern Vietnam, with a GDP of 3020 USD/year. Its economy depends mainly on natural conditions, especially agriculture. In the context of climate change, drought will be a natural disaster that greatly affects the economy and agriculture is no exception. Using the Pearson correlation coefficient evaluation method and building multi-linear regression equations, a good correlation was found between total evaporation and total monthly rainfall, monthly mean temperature, monthly maximum temperature and monthly minimum temperature. This is the basis for calculating potential future evaporation based on climate change scenarios. Calculating the drought index K with the input data of climate change scenarios for Vietnam, this analysis has calculated the drought evolution for the three driest months of the year (12, first, 2) for the period 2021- 2050 in Hai Duong province. Results show that with both scenarios (RCP 4.5 and RCP 8.5), the drought index K is at drought and very high drought levels. The drought level in RCP 8.5 is higher than in RCP 4.5 while the drought level at Chi Linh meteorological station is 1.4-1.5 times higher than that at Hai Duong meteorological station. It emerges that drought is clearly cyclical with the drought scenario RCP 8.5 which reaches its maximum every 9-10 years.
Assessment of meteorological drought in Balod district, India through GIScience and Remote sensing
Authors: Kumar Vibhanshu , Bharti Birendra
Published: January 2023

The present study was conducted in Balod district to assess meteorological drought events for prevention and future water resource management planning. The study area has a deficit in rainfall with a higher rainfall variation. From 1990 to 2020, the rainfall anomaly index (RAI) was used to calculate meteorological drought and monitor dry and wet periods in the area. Rainfall datasets from IMD daily gridded data of 0.25º × 0.25º spatial resolution were combined with the Geographic information system (GIS) environment. The results from the index revealed that the highest negative values were observed in the years 2000, 2002, 2008 and 2009 which have faced severe drought events. The findings from the study can assist in making a drought preparedness plan to mitigate the risk with effective water resources management.
Mirror neurons
Authors: А.А. Пальцын, , Н.Б. Свиридкина,
Published: January 2023

Представление о зеркальных нейронах было создано и разработано в начале 21 века группой итальянских врачей под руководством Джакомо Риззолатти. Так они стали называть нейроны, которые возбуждались не физическим движением, а наблюдением физического движения или даже размышлениями о движении. За способность ментального отражения физического движения нейроны стали называть зеркальными. Физическое движение - лучший способ избавлять людей от множества двигательных расстройств: травматология, инсульт, болезнь Паркинсона, детский церебральный паралич и др. Главный лечебный фактор при этих болезнях - движение, но оно затруднено или невозможно. Знания о зеркальных нейронах облегчают ситуацию. На них основывается идея и практика использования зеркальности наоборот - применяются когнитивные образы движения для восстановления нарушенных двигательных способностей. Сегодня есть много свидетельств успешности этого направления.

The idea of mirror neurons was created and developed at the beginning of the 21st century by a group of Italian physicians headed by Giacomo Rizzolatti. This is how they began calling the neurons that were excited not by a physical movement but by observing a physical movement or even thinking about it. For the ability to mentally reflect physical movements, these neurons were named mirror neurons. Physical movement is the best way to relieve people from many motor disorders, such as traumas, stroke, Parkinson’s disease, cerebral palsy, etc. The main therapeutic factor in these diseases is movement, but it is difficult or impossible. Knowledge about mirror neurons makes things easier. The idea and practice of using the reverse specularity is based on the mirror neurons; cognitive images of movement are used to restore impaired motor abilities. Today there is a lot of evidence for success of this trend.
MICROWAVE RADIOMETRIC METHOD FOR STUDYING PLASTIC FLOW WAVES IN ICE FORMATIONS
Authors: А.А. Гурулев, , Г.С. Бордонский,
Published: January 2023

Предложен метод поиска и исследования волн пластического течения основанный на спектральных радиометрических измерениях вблизи частоты 13 ГГц. Метод может применяться как при лабораторных, так и дистанционных измерениях разнообразных природных образований – ледяных покровов, ледников, мерзлых почв и грунтов.

A method for searching and studying plastic flow waves based on spectral radiometric measurements near a frequency of 13 GHz is proposed. The method can be used both for laboratory and remote measurements of various natural formations – ice sheets, glaciers, frozen soils and soils.
STUDY OF THE COMPOSITION OF ALKYLINDANES IN THE THERMOHYDROLYZATE OF KANGALAS COALS OF YAKUTIA
Authors: Ю.В. Рокосов, , Н.Н. Рокосова, , Т.В. Дикунова, , В.Ю. Рокосова,
Published: January 2023

С учетом закономерностей фрагментации углеводородов при ионизации электронным ударом, исследован состав алкилинданов и их возможных молекулярных предшественников в термогидролизате кангаласских гумусовых углей Якутии. В качестве их предшественников рассмотрены алкилнафталины, а в качестве промежуточных продуктов – алкилзамещенные дигидро- и тетрагидронафталины. Индивидуальные соединения идентифицировали по масс-спектрам с использованием базы данных NIST-11 и информационно-поисковых программ AMDIS и ChemStation. В итоге получены данные в пользу гипотезы существования закономерных связей между содержанием алкилинданов в продуктах термогидролиза гумусовых углей и наличием алкилнафталинов в составе термогидролизатов.

Taking into account the patterns of fragmentation of hydrocarbons during electron impact ionization, the composition of alkylindanes and their possible molecular precursors in the thermohydrolysate of Kangalas humus coals of Yakutia has been studied. Alkyl naphthalenes are considered as their precursors, and alkyl–substituted dihydro- and tetrahydronaphthalenes are considered as intermediates. Individual compounds were identified by mass spectra using the NIST-11 database and the AMDIS and ChemStation information retrieval programs. As a result, data were obtained in favor of the hypothesis of the existence of regular relationships between the content of alkylindanes in the products of thermohydrolysis of humus coals and the presence of alkyl naphthalenes in the composition of thermohydrolysates.
STUDY OF HYDROCARBONS IN THE THERMOHYDROLYSIS PRODUCTS OF YAKUTIAN BROWN COAL BY MASS- AND CHROMATO-MASS SPECTROMETRY METHODS
Authors: Ю.В. Рокосов, , Н.Н. Рокосова, , Т.В. Дикунова, , В.Ю. Рокосова,
Published: January 2023

Методами масс- и хромато-масс-спектрометрии исследован углеводородный состав продуктов термогидролиза бурого угля Кангаласского месторождения (Якутия). С учетом закономерностей фрагментации углеводородов при ионизации электронным ударом, исследована парафино-нафтено-ароматическая фракция термогидролизата с целью получения информации об ее групповом и индивидуальном составе. Индивидуальные соединения и их гомологи идентифицировали по масс-спектрам с использованием базы данных NIST-11 и информационно-поисковых программ AMDIS и ChemStation. В настоящей статье подведены итоги исследования углеводородов ближнего диапазона (≤ n-C18) распределения, за исключением алкилзамещенных инданов, инденов, нафталинов, дигидро- и тетрагидронафталинов, изучению состава которых будет посвящена отдельная публикация.

The hydrocarbon composition of the products of thermal hydrolysis of brown coal from the Kangalas deposit (Yakutia) was studied by mass and chromato-mass spectrometry methods. Taking into account the patterns of hydrocarbon fragmentation during electron impact ionization, the paraffin-naphthene-aromatic fraction of the thermohydrolyzate was studied in order to obtain information about its group and individual composition. Individual compounds and their homologues were identified by mass spectra using the NIST-11 database and AMDIS and ChemStation information retrieval programs. This article summarizes the results of the study of hydrocarbons in the near range (≤ n-C18) distribution, with the exception of alkyl-substituted indanes, indenes, naphthalenes, dihydro- and tetrahydronaphthalenes, the composition of which will be studied in a separate publication.
THE ROLE OF SPECIES of JUNIPER IN THE RESTORATION OF ARID SPARSE FORESTS IN NAKHCHIVAN AUTONOMOUS REPUBLIC
Authors: Г.Ф. Кулиева,
Published: January 2023

За последние 3 года экспедициями на территории Нахчыванской Автономной Республики, большая часть которого характеризуется горными ландшафтами, исследовано влияние глобального потепления и нехватки воды на деградацию местной флоры, в особенности в аридных лесах. Установлено, что главная роль в восстановлении аридных лесов Нахчыванской АР заключается в искусственном выращивании, главным образом южных склонах с выбором подходящих участков, доминирующих видов можжевельника. В статье отмечается также проведение соответствующих мероприятий по регулированию существующего водного баланса на склонах и даны соответствующие рекомендации.

Over the past 3 years, expeditions on the territory of the Nakhchivan Autonomous Republic, most of which is characterized by mountainous landscapes, have studied the impact of global warming and water shortage on the degradation of local flora, especially in arid forests. It has been established that the main role in the restoration of the arid sparse forests of the Nakhchivan Autonomous Republic lies in the artificial cultivation, mainly on the southern slopes with the selection of suitable sites, of the dominant species of juniper. The article also notes the implementation of appropriate measures to regulate the existing water balance on the slopes and gives appropriate recommendations.
DESIGN OF RIGID ORTHOTROPIC PANELS ACCORDING TO THE POST-BUCKLING STATE DURING COMPRESSION
Authors: О.В. Митрофанов,
Published: January 2023

Предложена методика проектирования прямоугольных панелей большой толщины из ортотропных материалов с учетом допустимости геометрически нелинейного поведения при нагрузках близких к расчетному уровню. Рассматриваемые панели относятся к категории жестких панелей, для которых на ранних этапах проектирования возможно учитывать только изгибные напряжения.

A method of designing rectangular panels of large thickness made of orthotropic materials is proposed, taking into account the permissibility of geometrically nonlinear behavior under loads close to the calculated level. The panels in question belong to the category of rigid panels, for which only bending stresses can be taken into account at the early stages of design.
DESIGN OF ORTHOTROPIC WING PANELS IN CS ACCORDING TO THE POST – BUCKLING STATE DURING COMPRESSION TAKING INTO ACCOUNT THE LIMITATIONS ON STRENGTH OR DEFLECTION
Authors: О.В. Митрофанов,
Published: January 2023

На основе аналитического решения геометрически нелинейной задачи предложена методика определения толщин сжатых ортотропных обшивок несущих панелей крыла воздушно – космического самолета. Учтены ограничения по статической прочности или прогибу при возможном закритическом поведении обшивки при расчетном уровне нагружения.

Based on the analytical solution of a geometrically nonlinear problem, a method is proposed for determining the thicknesses of compressed orthotropic sheaths of the bearing panels of the wing of an aerospace aircraft. The limitations on static strength or deflection with possible post-buckling behavior of the skin at the calculated loading level are taken into account.
PURIFICATION OF MARINE OIL-CONTAINING WATERS WITH THE OF A NATURAL SORBENT
Authors: В.П. Зайцев, , И.И. Бочкарева, , О.В. Рослякова, , Б.В. Палагушкин,
Published: January 2023

Предложен новый способ использования зоогумуса на основе личинок Musca Domestica в качестве сорбента для очистки воды от нефтепродуктов. Экспериментальные исследования сорбционных свойств зоогумуса проводились на модельных растворах, насыщенных нефтепродуктами. Начальная концентрация дизельного топлива и машинного масла в воде составила 29,0 и 16,8 мг/дм3 соответственно. По результатам проведенной работы были построены изотермы адсорбции зоогумусом машинного масла и дизельного топлива. Анализ изотерм показал, что зоогумус по отношению к исследуемым нефтепродуктам обладает положительной адсорбционной активностью. Экспериментально полученные изотермы адсорбции дизельного топлива и машинного масла были промоделированы с помощью классических эмпирических уравнений Ленгмюра и Фрейндлиха. Линейные формы изотерм позволяют получить постоянные параметры уравнений Ленгмюра и Фрейндлиха. Для каждой из представленных зависимостей после обработки были получены величины достоверной аппроксимации. Показано, что зоогумус имеет наибольшую сорбционную активность по отношению к дизельному топливу, чем по отношению к машинному маслу.

A new method of using Musca Domestica larvae-based zoohumus as a sorbent for water purification from oil products has been proposed. Experimental study of sorption properties of zoohumus were carried out on model solutions saturated with oil products. The initial concentration of diesel fuel and motor oil in water were 29.0 and 16.8 mg/dm3, respectively. Adsorption isotherms of motor oil and diesel fuel by zoohumus were built on the results of the work. Analysis of the isotherms showed that zoohumus has a positive adsorption activity in relation to the studied oil products. Experimentally obtained adsorption isotherms of diesel fuel and motor oil have been modeled using the classical empirical Langmuir-Freundlich equations. Linear forms of the isotherms allow to obtain the constant parameters of Langmuir-Freundlich equations. The value of accurate approximation was obtained for each of the presented dependencies after processing. The article shows that zoohumus has the higher sorption activity in relation to diesel fuel compared to engine oil.
Minerals and rocks of the Earth’s upper mantle in the collection of the Fersman Mineralogical museum RAS
Authors: Е.Л. Соколова,
Published: January 2023

В Минералогическом музее им. А.Е. Ферсмана РАН собрана представительная коллекция пород и минералов верхней мантии Земли, составляющая 339 образцов. В статье приводится описание коллекции, в таблицах сгруппированы данные по минеральному составу и количеству образцов, по их географическим привязкам и источникам поступления в музей. Мантийное вещество представлено преимущественно ксенолитами пород и ксенокристами минералов из кимберлитов. В коллекции присутствуют практически все основные типы мантийных пород, а также образцы редких мантийных образований. Изученность материала весьма неравномерна. Приблизительно две трети коллекции составляют образцы из кимберлитов Якутии; образцы из многих других, в том числе крупных месторождений, таких, например, как знаменитые кимберлитовые проявления ЮАР, представлены единичными или несколькими экземплярами. Семьдесят четыре отечественных и зарубежных исследователя и организации передавали в музей образцы мантийных пород и минералов в течение почти двух столетий. Особо следует отметить вклад известного геолога А.И. Пономаренко, подарившего музею уникальную коллекцию ксенолитов верхней мантии, добытых им на кимберлитовых трубках Якутии. Музей заинтересован в разностороннем изучении уже имеющегося материала широким кругом исследователей и в пополнении коллекции новыми образцами мантийных пород и минералов.
Peripheral Resistance to Arginine Vasopressin and Its Relationship with Plasmaosmolarityinaged Population
Authors:   Research Unit, Consorci Sanitari del Maresme, Mataró (Barcelona, Spain), M Serra-Prat , I Lorenzo ,   Research Unit, Consorci Sanitari del Maresme, Mataró (Barcelona, Spain), L Pérez-Cordon ,   Department of Pharmacy, Hospital of Mataró, Consorci Sanitaridel Maresme, Spain, L Campins ,   Department of Pharmacy, Hospital of Mataró, Consorci Sanitaridel Maresme, Spain, E Palomera ,   Research Unit, Consorci Sanitari del Maresme, Mataró (Barcelona, Spain), A Ruiz ,   Department of Biochemical Laboratory, Hospital of Mataró, Consorci Sanitari del Maresme, Spain, M Cabré ,   Department of Internal Medicine, Hospital of Mataró, Consorci Sanitari del Maresme, Spain, E Pleguezuelos ,   Department of Rehabilitation, Hospital of Mataró, Consorci Sanitari del Maresme, Spain
Published: January 2023

Background: The causes of age-related poor urine concentration capacity favouring low-grade chronic dehydration in aged populations are not well understood. Objectives: To explore links between age and plasma and urine osmolarity levels and a possible picture of peripheral resistance to arginine vasopressin (R-AVP) in an aged population. Design: observational cross-sectional study. Study population: communitydwelling subjects aged 70 years and older. Data collection: Blood and urine samples collected after 10 hours night fasting were analysed for osmolarity and copeptin levels (AVP surrogate). R-AVP was established based on a urinary osmolarity/copeptin ratrio<35. Results: 237 subjects were recruited (mean age 75.7 years, 52.7% women). Plasma osmolarity was similar between the sexes and age groups (70-79 and ≥80 years); whereas urine osmolarity was lower in women and in the older age group. Plasma hyperosmolarity (>295 mOsm/L) was present in no women and in 4.5% of men, and was significantly 14 times greater in the older group. R-AVP prevalence was 12.7% in the younger group vs 20.7% in the older group (p=0.252). Subjects with R-AVP, compared to without R-AVP, presented higher plasma osmolarity (287.6 vs 285.4 mOsm/L; p=0.023) and higher prevalence of plasma hyperosmolarity (8.7% and 0.7%; p=0.053). R-AVP was also related with IL-6 and creatinine levels and with loop diuretic use. Conclusions: Urine concentration capacity decreases and plasma hyperosmolarity increases after the age of 80 years. Fourteen percent of ≥70 year’s old population present R-AVP, which greatly increases the risk of plasmahyperosmolarity and is related with loop diuretic use, and IL-6 and creatinine levels.
Family Functionality after Covid-19
Authors:   UMF #32 IMSS Guadalupe, Nuevo Leon, GLD Laillete , ARJ Francisco ,   UMF #32 IMSS Guadalupe, Nuevo Leon
Published: January 2023

General Objective: To evaluate family functionality after the health emergency at the first level of care. Material and Methods: A prospective, non-comparative cross-sectional study was carried out through studies of family functionality with the ff-sil instrument and evaluation of the marital subsystem with the Chavez-Velasco marital subsystem instrument applied to the families assigned to the unit of family medicine No. 32 of the IMSS of Guadalupe, Nuevo León. Through nonprobabilistic convenience sampling. Results: 609 participants were included, of which 30.24% had some degree of family dysfunction, this was identified as 19.58% of dysfunction at the marital subsystem level. A 32.73% of family functionality alterations were found in the families that had Home office X2:13 and a p of 0.01. Conclusion: The health contingency is a watershed of the need to interact more as a family, due to social isolation the family lives more, however there is the presence of family dysfunction and it is important to identify it for its timely management.
High Social Media Use among Adolescents Associated with Increased High-Risk Behaviors and Poor Academic Outcomes
Authors:   Department of Pediatrics, Quillen College of Medicine, East Tennessee State University, USA, AM Yoders , SA Ray ,   Department of Pediatrics, Quillen College of Medicine, East Tennessee State University, USA, MA Quinn ,   Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, USA, K Phalen ,   College of Arts and Sciences, East Tennessee State University, USA, MD Cabral ,   Department of Pediatrics and Adolescent Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, USA, M Shrestha ,   Department of Pediatrics and Adolescent Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, USA, D Wood ,   Department of Pediatrics, Quillen College of Medicine, East Tennessee State University, USA
Published: January 2023

Purpose: With the marked increase in social media apps over the last two decades and teens’ dramatic increase in screen time, research examining the impacts of social media on teenage health outcomes is urgently needed. The purpose of this study is to examine the relationship between adolescent social media use and high-risk behaviors (alcohol use, tobacco, vaping, sexual activity) and academic outcomes (ability to get good grades and complete homework). Methods: 234 adolescents were recruited via convenience sampling at two suburban/rural clinics. A survey assessed hours of social media use, participation in high-risk behaviors, and impact on academic outcomes. Variables were recoded into bivariate categories and multiple logistic regressions were conducted using SPSS, controlling for age, gender, race, and insurance status. Results: High users of social media (4+ hours/day) were 3.4 and 3.0 times more likely to use alcohol (p<0.05) and tobacco (p<0.01), respectively. Highusers were also 3.2 and 3.0 times more likely to report that their social media use impacted their ability to get good/acceptable grades (p<0.01) and complete homework (p<0.01), respectively. Conclusions: High levels of social media use were associated with increased likelihood of alcohol and tobacco use and had a negative effect on youth’s academic performance. Screening of adolescent social media use will better identify youth at risk for potentially harmful effects of excess social media use, allowing providers to intervene with the proper education for youth and their guardians.
Polycythemia Vera leading to Jaundice and Marantic Endocarditis, A Case Presentation
Authors:   Department of Medical Education/Family Medicine, Good Samaritan Hospital, USA, R Pasricha , S Rashidzada ,   Department of Medical Education/Family Medicine, Good Samaritan Hospital, USA, J Adiyody ,   Department of Internal Medicine, Good Samaritan Hospital, USA, P Dave ,   Department of Medical Education/Family Medicine, Good Samaritan Hospital, USA, A Kuang ,   Department of Medical Education/Family Medicine, Good Samaritan Hospital, USA
Published: January 2023

Polycythemia vera is an uncommon myeloproliferative neoplasm characterized by the abnormal proliferation and maturation of hematopoietic stem or progenitor cells. It is also known as one of the BCR-ABL1 negative myeloproliferative neoplasms, along with essential thrombocythemia and myelofibrosis. Incomparison to essential thrombocythemia and myelofibrosis, polycythemia is driven by JAK2 mutations, specifically JAK2V617F, an activating mutation encoding a tyrosine kinase [1]. This variant mutation is correlated with increased erythropoiesis and myelopoiesis, lower platelet count, higher incidence of splenomegaly, pruritus and thrombotic events. A 58-year-old male presented to the Emergency Department complaining of pruritus and painless jaundice. Comprehensive blood count revealed an elevated white blood cell count, hemoglobin/ hematocrit, and platelets. Total bilirubin was elevated at 30.3g/dL, with a direct bilirubin of 27g/dL. A Jak- 2 mutation was positive, which suggested a diagnosis of polycythemia vera although atypical given his jaundice. An Erythropoietin level was found to be less than 1, suggesting a primary cause of polycythemia vera. In addition, the patient was found to have marantic nonbacterial thrombotic endocarditis on transesophageal echocardiogram. Patient was treated with aspirin to prevent thrombotic events, hydroxyurea and cholestyramine. The patient’s physical examination of profuse jaundice along with an elevated direct bilirubin count of 27g/dL typically does not correlate to a presentation of polycythemia vera. Through further workup, the patient did not demonstrate hemolytic or intrahepatic causes, both intrinsic and extrinsic to the liver, which would of explained the jaundice presentation. This led to a conclusion that the patient’s polycythemia vera most likely caused the jaundice presentation.
Clinical Evidence of Brain Effect Difference between True Point and False Point: A Meta-analysis Based FMRI
Authors:   Affiliated Hospital of Traditional Chinese Medicine, Guangzhou Medical University, Guangzhou, Guangdong 510130, China, C Chen , Z Chen , A Liu , Q Zhang ,   Affiliated Hospital of Traditional Chinese Medicine, Guangzhou Medical University, Guangzhou, Guangdong 510130, China, W Huang ,   Affiliated Hospital of Traditional Chinese Medicine, Guangzhou Medical University, Guangzhou, Guangdong 510130, China, L Lu ,   Affiliated Hospital of Traditional Chinese Medicine, Guangzhou Medical University, Guangzhou, Guangdong 510130, China, Y Mo ,   Affiliated Hospital of Traditional Chinese Medicine, Guangzhou Medical University, Guangzhou, Guangdong 510130, China, S Zheng ,   Affiliated Hospital of Traditional Chinese Medicine, Guangzhou Medical University, Guangzhou, Guangdong 510130, China
Published: January 2023

Imaging studies after acupuncture at acupoints and sham acupoints have shown significant changes in the function of specific parts of the brain, but these findings are not consistent. In this meta-analysis, we examined different studies to determine whether there are differences in brain function changes in the brain imaging findings of acupuncture at real and sham points. Pubmed, Embase, Cochrane, CNKI, VIP and Wanfang databases were used to search for acupuncture brain imaging literatures published by May 2020. Study selection, quality assessment and data extraction were carried out by two independent researchers. The whole brain function data of acupuncture points were analyzed by sdM-PSI. Thirteen studies met the inclusion criteria, including 266 subjects enrolled at acupoints including Taichong, Xingjian, Neiting, Guangming, Neiguan, Baihui, Fengchi, Sanyinjiao, Zusanli, Wai Guan, Feng Long, Zhongdu, Xiangu, 214 true acupoints, 186 false acupoints. Our analysis revealed that the brain region positively activated by acupuncture was Right fusiform gyrus, BA 30, Right inferior gyrus, Stationarity BA 48, and Right superior Temporal gyrus, BA 42. These findings suggest that the limbic system is the common difference in brain function after acupuncturing at different true and false acupoints.
Belief, Knowledge and Perception of Causes of Low Back Pain among Rural and Urban Dwellers in a Nigerian City
Authors:   Department of Medical Rehabilitation, Faculty of Basic Medical Sciences, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Nigeria, AO Ojoawo , AJ Ajibade ,   Department of Medical Rehabilitation, Faculty of Basic Medical Sciences, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Nigeria
Published: January 2023

The study examined the belief, knowledge and perception of causes of low back pain among rural and urban dwellers in Nigeria. One hundred and ninety-two (192) participants (99 from rural and 93 from urban community) were recruited for this study. A modified questionnaire from a previous similar study from India was administered to each of the participants to complete. The completed questionnaire was collected immediately. Data was analyzed using descriptive and inferential statistics, alpha level, was set at 0.05. Result showed that one hundred and thirty-three (71 urban and 62 rural) participants (133, 69.3%) perceived that pile was very important as a cause of low back pain. Considering the fear avoidance belief, 149 (69 urban and 80 rural) 77.6% agreed that low back pain get progressively worse in life. With regard to the knowledge of participants, 72 (45%) participants were able to answer two or three questions correctly and so were termed partially knowledgeable. Nature of work has significant association with each of the following perception, pile (X²=203.38) and poor mattresses (X²=237.830) as major cause of low back pain. This study concluded that many residents in Ile-Ife are not adequately knowledgeable about LBP and had negative perception and beliefs regarding low back pain (LBP).
A novel blood brain barrier-permeable IRE1 kinase inhibitor for adjuvant glioblastoma treatment in mice.
Authors: Pelizzari-Raymundo Diana , Doultsinos Dimitrios , Pineau Raphael , Sauzay Chloé , Koutsandreas Thodoris , Carlesso Antonio , Gkotsi Elena , Negroni Luc , Avril Tony , Chatziioannou Aristotelis , Chevet Eric , Eriksson Leif A. , Guillory Xavier
Published: January 2023

Inositol Requiring Enzyme 1 (IRE1) is a bifunctional serine/threonine kinase and endoribonuclease. It is a major mediator of the Unfolded Protein Response (UPR), which is activated upon endoplasmic reticulum (ER) stress. Tumor cells experience ER stress due to adverse microenvironmental cues such as hypoxia or nutrient shortage and high metabolic/protein folding demand. To cope with those stresses, cancer cells can rely on IRE1 signaling as an adaptive mechanism. Herein, we report the discovery of novel IRE1 inhibitors identified through the structural exploration of the IRE1 kinase domain. We characterized the candidates in vitro and in cellular models and showed that all molecules inhibit IRE1 signaling and sensitize glioblastoma cells to the standard chemotherapeutic temozolomide (TMZ). We next selected a Blood-Brain Barrier (BBB) permeable inhibitor (Z4P) among these molecules and demonstrated its ability to inhibit Glioblastoma (GB) growth and to prevent relapse in vivo when administered together with TMZ. The hit compound disclosed in this study satisfies an unmet need for targeted, non-toxic IRE1 inhibitors and our results support the attractiveness of IRE1 as an adjuvant therapeutic target in GB.
The “Carbonyl-Lock” Mechanism Underlying Non-Aromatic Fluorescence in Biological Matter
Authors: Díaz Mirón Gonzalo , Semelak Jonathan A. , Grisanti Luca , Rodriguez Alex , Conti Irene , Stella Martina , Seriani Nicola , Došlić Nađa , Rivalta Ivan , Garavelli Marco , Estrin Dario A. , Kaminski Schierle Gabriele S. , González Lebrero Mariano C. , Hassanali Ali , Morzan Uriel N.
Published: January 2023

Challenging the basis of our chemical intuition, recent experimental evidence reveals the presence of a new type of intrinsic fluorescence in biomolecules that exists even in the absence of aromatic or electronically conjugated chemical compounds. The origin of this phenomenon has remained elusive so far. In the present study, we identify a mechanism underlying this new type of fluorescence in different biological aggregates. By employing non-adiabatic ab initio molecular dynamics simulations combined with an unsupervised learning approach, we characterize the typical ultrafast non-radiative relaxation pathways active in non-fluorescent peptides. We show that the key vibrational mode for the non-radiative decay towards the ground state is the carbonyl elongation. Non-aromatic fluorescence appears to emerge from blocking this mode with strong local interactions such as hydrogen bonds. This "carbonyl-lock" mechanism for trapping the excited state leads to the fluorescence yield increase observed experimentally, and paves the way for design principles to realize novel non-invasive biocompatible probes with applications in bioimaging, sensing, and biophotonics.
Synthesis and Structure-Activity Relationship Studies of C(13)-Desmethylene-(−)-Zampanolide Analogs
Authors: Brütsch Tobias Michael , Cotter Etienne , Lucena-Agell Daniel , Redondo-Horcajo Mariano , Davies Carolina , Pfeiffer Bernhard , Pagani Sandro , Berardozzi Simone , Díaz J. Fernando , Miller John H. , Altmann Karl-Heinz
Published: January 2023

We have prepared a series of partially reduced or demethylated analogs of the natural microtubule stabilizer (−)-zampanolide and we have assessed their antiproliferative activity, their microtubule-binding affinity and their effects on the cellular microtubule network and on cell cycle progression. For reasons of synthetic efficiency, these analogs were derived from 13-desmethylene-(-)-zampanolide, which we had previously shown to be an equally potent cancer cell growth inhibitor as the natural product. The synthesis of all compounds was based on a unified strategy that included final formation of the macrobicyclic core by an intramolecular HWE reaction and a stereoselective aza-aldol reaction to establish the C(20) stereocenter as the key steps. For the 5-desmethyl macrocycle, ring-closure relied on macrolactonization; however, elaboration of the macrocyclic aldehyde into the corresponding zampanolide analog was unsuccessful.All structural modifications investigated led to reduced cellular activity and lower microtubule-binding affinity compared to the parent 13-desmethylene-(–)-zampanolide, which may be ascribed to increased conformational flexibility due to the formal reduction of double bonds or the removal of the C(17)-methyl group. Notwithstanding this general trend, the cellular potency of 2,3-dihydro-13-desmethylene zampanolide as the most potent analog identified remained within a 9-fold range of that of 13-desmethylene-(–)-zampanolide (for 5 out of 6 cell lines). Notably, while the formal reduction of the C=C double bond of the enone system that is required for the covalent attachment of (−)-zampanolide to beta-tubulin caused a drop in antiproliferative activity of several hundred fold, the compound does bind to microtubules and shows the typical cellular hallmarks of a microtubule-stabilizing agent.
General and Scalable Approach to Trifluoromethyl-substituted Cyclopropanes
Authors: Mykhailiuk Pavel , Ahunovych Volodymyr , Klipkov Anton , Bugera Maksym , Tarasenko Karen , Trofymchuk Serhii , Stanko Oleh , Boretskyi Andrii , Zheludenko Mykola , Sadkova Iryna
Published: January 2023

CF3-cyclopropanes were prepared on a multigram scale by deoxyfluorination of cyclopropane carboxylic acids or their salts with sulfur tetrafluoride. For labile α-pyridine acetic acids, only the use of salts allowed to obtain the needed products. Derivatization of CF3-cyclopropanes into building blocks ready for the direct use in medicinal chemistry was performed.
MODERN ECONOMIC THEORY: SUBJECT AND METHODOLOGY
Authors: Елена Евгеньевна Николаева,
Published: January 2023

Цель статьи - показать значимость экономико-теоретического знания, актуальность политической экономии в современных условиях. Научная новизна заключается в расширении, как предмета политической экономии, так и методологических подходов к анализу явлений и процессов, активному использованию «синтезирования» в познании экономики и общества. В статье представлен круг вопросов, входящих, по мнению автора, в поле зрения современной политической экономии, а также предложено использовать синтез политической экономии с другими направлениями экономической мысли и разделами экономической науки. Это расширение связано с трансформацией общества и экономики не только в национальном, но и мировом масштабе.

The purpose of the article is to show the importance of economic and theoretical knowledge, the relevance of political economy in modern conditions. The scientific novelty lies in the expansion of both the subject of political economy and methodological approaches to the analysis of phenomena and processes, the active use of "synthesis" in the knowledge of economics and society. The article presents a range of issues that, according to the author, are in the field of view of modern political economy, and it is also proposed to use the synthesis of political economy with other areas of economic thought and sections of economic science. This expansion is associated with the transformation of society and the economy not only on a national, but also on a global scale.
ECONOMIC THEORY AND PHILOSOPHY: THE NEED TO RESUME INTERDISCIPLINARY DIALOGUE
Authors: Валерий Петрович Федоров,
Published: January 2023

В статье рассмотрена перспектива методологического обновления экономической теории на основе комплексной инвентаризации исторического диалога между экономистами и философами, реконструкции философских оснований экономических доктрин и школ экономической мысли. Автор предлагает подойти к обновлению экономического теоретического знания в России с его философских оснований, полагая, что только в этом случае мы получим шанс не попасть в «колею» вторичного пересказа уже отшумевших на Западе дискуссий, а, напротив, предложить оригинальную концепцию с надеждой на формирование новой парадигмы экономической теории, потребность в которой настоятельно ощущается в Российской Федерации.

The article considers the prospect of methodological updating of economic theory on the basis of a comprehensive inventory of historical dialogue between economists and philosophers, reconstruction of the philosophical foundations of economic doctrines and schools of economic thought. The author proposes to approach the renewal of economic theoretical knowledge in Russia from his philosophical grounds, believing that only in this case we will get a chance not to get into the "rut" of a secondary retelling of the discussions that have already aroused in the West, but, on the contrary, to propose an original concept with the hope of forming a new paradigm of economic theory, the need for which is strongly felt in the Russian Federation.
ON THE TRAJECTORY OF SOCIO-ECONOMIC DEVELOPMENT OF THE RUSSIAN FEDERATION FROM THE STANDPOINT OF THEORETICAL ECONOMY
Authors: Валерий Александрович Гордеев, , Сергей Владимирович Шкиотов,
Published: January 2023

Цель статьи - обосновать объективную необходимость смены курса российской макроэкономической политики, перехода к модели жесткой мобилизационной экономики. В работе дана оценка траектории социально-экономического развития РФ с позиции теоретической экономики. Охарактеризована концепция теоретической экономии как нового парадигмального мейнстрима в социально-экономических исследованиях. Научная новизна исследования заключается в полиметодологическом подходе к анализу траектории социально-экономического развития РФ. Установлено, что в условиях специальной военной операции, небывалой угрозы России со стороны недружественных стран Запада объективной необходимостью становится исправление траектории социально-экономической динамики. Требуется немедленное внедрение жесткой мобилизационной экономики, централизованного государственного планирования, возобновления госзаказа в соответствии с государственным планом РФ и национализации предприятий в случае невыполнения плана.

The purpose of the article is to substantiate the objective need to change the course of Russian macroeconomic policy, the transition to a model of a tough mobilization economy. The paper gives an assessment of the trajectory of the socio-economic development of the Russian Federation from the standpoint of theoretical economics. The concept of theoretical economy as a new paradigm mainstream in socio-economic research is characterized. The scientific novelty of the study lies in the polymethodological approach to the analysis of the trajectory of the socio-economic development of the Russian Federation. It has been established that in the conditions of a special military operation, an unprecedented threat to Russia from unfriendly Western countries, it becomes an objective necessity to correct the trajectory of socio-economic dynamics. The immediate introduction of a tough mobilization economy, centralized state planning, the resumption of state orders in accordance with the state plan of the Russian Federation, and the nationalization of enterprises in case of failure to fulfill the plan is required.
THE RESERCH OF INSTITUTIONAL AND STRUCTURAL FEATURES OF ASSESSING THE QUALITY OF INNOVATIVE DEVELOPMENT IN THE NEW SOCIO-TECHNICAL CONDITIONS OF THE DEVELOPMENT OF THE GLOBAL ECONOMY
Authors: Бахадыр Джуманиязович Матризаев,
Published: January 2023

Наличие более совершенных институтов облегчает многие аспекты экономики. Но это обстоятельство, принимая во внимание другие факторы, может привести к постепенному снижению его эффективности в продвижении инноваций. Предлог, стоящий за этим, заключается в том, что зрелые институты увеличивают затраты бизнеса на соблюдение требований законодательства. Ввиду этого правительства многих стран пытаются найти подходящий подход к вмешательству для поощрения инноваций. Данное исследование направлено на оценку нелинейного влияния развития институционального качества на инновации. Результаты, полученные в рамках данного исследования с использованием панельной модели выполнимых обобщенных наименьших квадратов, подтверждает актуальность кривой Кузнеца инновационно-институционального качества для четырех групп стран, разделенных в соответствии с их уровнем развития по индексу развития человеческого капитала: высокоразвитая, развитая, развивающаяся, низкоразвитая. Исследование показало, что во всех группах стран наблюдается обратная U-образная зависимость между развитием институционального качества и инновациями, что указывает на предлог обременительного воздействия нормативных актов. Кроме того, это бремя облегчается с повышением уровня экономического развития, поскольку кривая в странах из низкоразвитой группы изгибается выше по сравнению со странами из высокоразвитой группы.

Modernized institutions facilitates many aspects of the economy. But this circumstance, taking into account other factors, may lead to a gradual decrease in its effectiveness in promoting innovation. The pretext behind this is that mature institutions increase the costs of businesses to comply with legal requirements. In view of this, many Governments are trying to find an appropriate approach to intervention to encourage innovation. This study is aimed at assessing the nonlinear impact of the development of institutional quality on innovation. The results obtained within the framework of this study using a panel model of feasible generalized least squares confirm the relevance of the Kuznets curve of innovation and institutional quality for four groups of countries divided according to their level of development according to the human capital development index: highly developed, developed, developing, low-developed. The study showed that in all groups of countries there is an inverse U-shaped relationship between the development of institutional quality and innovation, which indicates the pretext of burdensome impact of regulations. In addition, this burden is relieved with an increase in the level of economic development, since the curve in countries from the low-developed group bends higher compared to countries from the highly developed group.