bluuebunny/crossref_metadata_2025 huggingface dataset:
hTERT Promotes CRC Proliferation and Migration by Recruiting YBX1 to Increase NRF2 Expression
Authors: Gong Chunli , Yang Huan , Wang Sumin , Liu Jiao , Li Zhibin , Hu Yuyang , Chen Yang , Huang Yu , Luo Qiang , Wu Yuyun , Xiao Yufeng
Published: January 2021

Background: High human telomerase reverse transcriptase (hTERT) expression is related to severe Colorectal Cancer (CRC) progression and negatively related to CRC patient survival. Previous studies have revealed that hTERT can reduce cancer cellular Reactive Oxygen Species (ROS) levels and accelerate cancer progression; however, the mechanism remains poorly understood. NFE2‑related factor 2 (NRF2) is a molecule that plays a significant role in regulating cellular ROS homeostasis, but whether there is a correlation between hTERT and NRF2 remains unclear. Herein, we sought to determine the relationship of hTERT and NRF2 in the progression of CRC and to elucidate the underlying molecular mechanisms.Methods: qPCR, Western blot, Immunohistochemistry, immunofluorescence assays were used to detect the mRNA and protein expression of hTERT, NRF2 and YBX1 in CRC cell lines and tissues.CCK8 and colony formation were used to detect the proliferation of CRC cells, transwell assay was used to detect the migration of CRC cells. Dual-luciferase reporter assays were used to detect the promoter activity of NRF2. DNA pull-down/MS analysis was used to identify NRF2 promoter binding proteins. ChIP-qPCR was used to detect the YBX1binding sequences of NRF2 promoter.Results: Both hTERT and NRF2 are highly expressed in CRC tissues and associated with poor diagnosis. hTERT increases NRF2 expression at both the mRNA and protein levels. hTERT increases CRC proliferation and migration by inducing NRF2 upregulation. Moreover, hTERT primarily upregulates NRF2 by increasing NRF2 promoter activity rather than by regulating NRF2 mRNA or protein stability, and hTERT recruits YBX1 to upregulate NRF2 promoter activity thus increases NRF2 expression and enhances CRC proliferation and migration.Conclusions: hTERT facilitates CRC proliferation and migration by upregulating NRF2 expression through the recruitment of the transcription factor YBX1 to activate the NRF2 promoter.
Comparison of Sacroiliac Biopsies and Magnetic Resonance Imaging Examinations in Non-Radiographic Axial Spondyloarthritis
Authors: Wang Dan min , Gong Yao , Hou Zhi duo , Liu Yuan , Peng Jian hua , Zhang Yu ping , Shen Feng cai , Liang Hong jin , Lin Ling , Xiao Zhengyu
Published: January 2021

Background : Early diagnosis and treatment are the key to improve the prognosis of axial spondyloarthritis (axSpA), therefore, we aimed to evaluate the diagnostic value of magnetic resonance imaging (MRI) and pathological examination of the sacroiliac joint (SIJ) for non-radiographic axSpA (nr-axSpA). Methods : Fine needle aspiration biopsy of bilateral SIJs was performed in 107 patients with nr-axSpA after MRI examination. The active inflammatory manifestations and chronic structural changes in SIJs were evaluated using MRI. The pathological changes of SIJ specimens were examined using microscopy. Results : Bone marrow edema (BME) was present in 67/214 joints on MRI (31.3%). The proportion of pannus formation and inflammatory cell infiltration were up to 63.8% and 53.4% in patients without BME on MRI, which were not significantly lower than 75.0% and 58.3% in patients with BME on MRI. The inflammatory infiltrating cells were mainly CD3 + T lymphocytes and CD68 + macrophages. In the group with normal cartilage on MRI, the proportions of chondrocytes and cartilage matrix degeneration were 22.2% and 44.9%，respectively, which was not significantly lower than those in the group with abnormal cartilage on MRI (35.7% and 46.4%). However, a significantly higher proportion of pannus invasion was observed in the latter (26.6% vs 57.1%, P =0.001). In the group with a normal bone plate on MRI, the incidence of subchondral pannus formation and bone plate destruction was as high as 74.0% and 71.7%, with no significant difference compared with that in the group with bone erosion on MRI (88.9% and 88.3%). Conclusions: Pathological examination is more sensitive for detecting inflammatory and structural changes in early sacroiliitis than MRI examination. Key words : non-radiographic axial spondyloarthritis, sacroiliac joint, aspiration biopsy, magnetic resonance imaging.
Characteristics of Inflammatory Storm in BALF of Severe Pneumonia in Children: A Case Control Study
Authors: Deng Fang , Cao Hui ling , Liang Xiao hua , Li Qu bei , Yang Yang , Zhao Zhi hua , Tan Jun jie , Fu Guo , Shu Chang
Published: January 2021

Background: It is difficult to collect bronchoalveolar lavage fluid (BALF) from children. There are few studies on inflammatory storms in BALF of children with pneumonia. Therefore, we will retrospectively investigate characteristics of inflammatory storms in BALF of children with pneumonia in our hospital.Methods: This retrospective study included 161 children with pneumonia. Pediatric pneumonia was divided into two groups: mild and severe pneumonia, according to the clinic diagnosis. All clinic information and data came from our hospital’s database. Blood and BALF samples were collected and measured by Clinical laboratory and Clinical Molecular Medical Center. Flow cytometry was performed to detect the levels of cytokines, including IL-2, IL-4, IL-6, IL-10, IL-17A, TNF-α and IFN-γ. We performed receiver operator characteristic curve (ROC) and spearman correlation to evaluate the role of BALF inflammatory cytokines and cells in pneumonia.Results: 1) The levels of IL-6, IL-10, IL-17A, and TNF-α, and ratios of IL-6 to IL-10 and TNF-α to IL-10 in BALF of severe pneumonia group were higher than those of mild pneumonia group. 2) The number of inflammatory cells and the percentage of neutrophils in BALF of severe pneumonia group increased, and the percentage of macrophages decreased, compared with the mild pneumonia group. 3) ROC analysis showed that the levels of IL-6, IL-10 and TNF-α, and ratios of IL-6 to IL-10 and TNF-α to IL-10, the number of inflammatory cells and neutrophils, as well as the percentage of neutrophils exceeded the cut-off value (60.37pg/mL, 2.54pg/mL, 13.07pg/mL, 29.30, 1.57, 3140.00*109/L, 768.00*109/L, 43.00%, respectively) could be used to distinguish children with severe pneumonia from children with mild pneumonia. While the percentage of macrophages in BALF decreased to below the cut-off value (36.00%) also had the discrimination ability. 4) The BALF levels of IL-6, IL-10, TNF-α and IFN-γ were correlated, positively with the inflammatory cell count and the percentage of neutrophils, and negatively with the percentage of macrophages.Conclusion: In severe pediatric pneumonia, BALF inflammatory cytokines and inflammatory cell infiltration are more intense, especially above the cut-off value. This study demonstrates that these inflammatory signals are potential biomarkers for predicting the severity of pediatric pneumonia.Trial registration: This study approved by the Medical Research Ethics Committee of Children’s Hospital of Chongqing Medical University, registered in http://www.chictr.org.cn/, No. ChiCTR2000034048(registration date, June 22, 2020).
Clinical Effect of a New Type of Transpedicular Reducer for Fracture Reduction via Pedicle and Bone Grafting Combined With Pedicle Screw Fixation for Thoracolumbar Burst Fractures
Authors: cai menghan , Xin Zhijun , Kong Weijun , Du Qian , Ji Wenjun , Wu Fujun , Li Jin , He Jialin , Liao Wenbo
Published: January 2021

BackgroundShort-segment transpedicular screw fixation is a common method for the treatment of thoracolumbar burst fractures (TBFs). When it is used, the anterior middle columns of the fractured vertebral body lack good support, resulting in fractured vertebral bodies decreased height and difficult to reduct.Therefore,the purpose of this study was to evaluate the clinical effect of a new type of transpedicular reducer that we designed for fractured vertebral body reduction and bone grafting in the treatment of TBFs.MethodsA total of 9 patients with TBFs who agreed to be treated with the new transpedicular reducer for fracture reduction via pedicle and bone grafting combined with pedicle screw fixation were retrospectively analysed. We measured the anterior and middlel heights of the injured vertebrae, the ratios of the anterior and middlel heights of the injured vertebral body to the respective heights of the adjacent uninjured vertebral bodies (AVBHr and MVBHr, respectively), and the Cobb angle of patients at different stages before and after surgery, and evaluated the distribution of bone grafts and bone healing 3 days and 12 months after the operation.ResultsThe anterior height of the injured vertebrae before the operation; after application of the transpedicular reducer; and 3 days, 3 months, 6 months and 12 months after the operation were 17.56±3.74 mm; 27.70±2.53 mm; and 29.08±2.52 mm, 28.36±1.93 mm, 28.12±1.42 mm, and 27.96±0.72 mm, respectively. The mid-heights of the injured vertebrae were 21.36±4.20 mm; 26.74±1.00 mm; and 27.70±2.01 mm, 27.05±2.45 mm, 26.94±1.84 mm, and 26.83 ±2.45 mm, respectively. The Cobb angles of the injured vertebrae were 3.80±1.44°; 1.26±1.00°; and 0.72±0.70°, 1.03±0.65°, 1.12±0.63°, and 1.34±0.56°, respectively. The allogeneic bones were distributed in the anterior and middle columns 3 days after the operation, and the bone had healed well 12 months after the operation.ConclusionThe new transpedicular reducer has a good reduction, allogeneic bone support, and clinical treatment effect for TBFs through pedicle fracture reduction and bone grafting combined with pedicle screw fixation.
Asymptomatic Malaria And Glycemic Control Among Type 2 Diabetes Mellitus Patients In A Rural Tertiary Health Facility In Ido- Ekiti, Southwestern Nigeria- A Cross Sectional Study.
Authors: Ibrahim Azeez Oyemomi , Agbesanwa Tosin Anthony , Agboola Segun Mathew , Shabi Olabode Muftau , Ajetunmobi Adewumi Oluwaserimi , Ismail Waheed Olalekan
Published: January 2021

Background: : Despite the high burden of Asymptomatic Malaria and Type 2 diabetes mellitus in sub-Saharan African, limited data exist regarding their co-occurrence and its associated clinical impacts of asymptomatic malaria parasitaemia on Type 2 diabetes mellitus in rural setting. The purpose of this study is to determine the prevalence of glycemic control and asymptomatic malaria parasitaemia; and to investigate the influence of socio-demographic characteristics and asymptomatic malaria parasitaemia on glycemic control among patients with Type 2 diabetes mellitus.Methods: Hospital-based cross-sectional study was conducted on 150 T2DM patients at Federal Teaching Hospital, Ido-Ekiti, SouthWestern Nigeria, between April and September 2019. Systematic random sampling technique was adopted to recruit the respondents. Socio-demographic data were obtained using a semi- structured interviewer administered questionnaire and clinical files. Venous blood samples were collected and processed for glycosylated haemoglobin sugar estimation and malaria parasite detection by microscopy. Data were analyzed using SPSS version 20.0. Multivariate logistic regression analysis was used to identify the influence of asymptomatic malaria parasitaemia and the socio-demographic profile on glycemic control.Results: The mean age, mean glycemic control and mean parasite density of the respondents were 64.8±11.1 years, 6.9±2.1% and 1123.4±433.8 respectively. The prevalence of poor glycemic control and asymptomatic malaria parasitaemia were 30.0% and 14.0% respectively. Old age, female gender, lack of formal education and asymptomatic malaria parasitaemia were associated with poor glycemic control.Conclusion: The study revealed that Type 2 diabetes mellitus patients in Ido-Ekiti, Nigeria, harbor asymptomatic malaria parasitaemia and that Asymptomatic malaria parasitaemia, old age, female gender and illiteracy were negative predictors of glycemic control. Therefore, type 2 diabetes mellitus patient with poor glycemic control should be screened for asymptomatic malaria parasitaemia. Also, respondents with these identified predictors should be targeted with focus care and qualitative health education to improve their glycemic control level.
Indicadores econômico-financeiros de empresas brasileiras: uma comparação entre setores
Authors: Vinícius Giovani Jacintho  , Adriana Kroenke
Published: January 2021

Banco de dados brutos de pesquisa.
A Mini Review on Emerging Targets and Approaches for the Synthesis of Anti-viral Compounds: In Perspective to COVID-19
Authors: Gokada Maheswara Rao , Pasupuleti Visweswara Rao , Bollikolla Hari Babu
Published: January 2021

The novel Coronavirus disease (COVID-19) is an epidemic disease that appeared at the end
of the year 2019 with a sudden increase in number and came to be considered as a pandemic disease
caused by a viral infection which has threatened most countries for an emergency search for new
anti-SARS-COV drugs /vaccines. At present, the number of clinical trials is ongoing worldwide on
different drugs i.e. Hydroxychloroquine, Remedisvir, Favipiravir that utilize various mechanisms of
action. A few countries are currently processing clinical trials, which may result in a positive outcome.
Favipiravir (FPV) represents one of the feasible treatment options for COVID-19, if the result
of the trials turns out positive. Favipiravir will be one of the developed possibly authoritative drugs
to warrant benefits to mankind with large-scale production to meet the demands of the current pandemic
Covid-19 outbreak and future epidemic outbreaks. In this review, the authors tried to explore
key molecules, which will be supportive for devising COVID-19 research.
The effects of livestock’s waste utilization as fertilizer on coffee plant’s growth
Authors: Widiatmono Bambang Rahadi
Published: January 2021

Cattle manure contains high organic matter, so that this material is commonly used as plant nutrients in a form of organic fertilizer. In order to get a better understanding on the use of cow manure, the objectives of this research are (1) to determine the influence of liquid waste and solid livestock as fertilizer on soil quality and (2) to study the effect of both liquid and solid fertilizer on coffee plant growth. In this research, Completely Randomized Design (CRD) was employed as a research design, while data analysis was conducted using ANOVA. The F statistical test was applied to measure whether all independent variables could influence the dependent variable by using 5% and 1% (Alpha) degrees. The results showed that one time application of livestock wastewater improved C-organic chemical properties, N, P, CEC, Ca and Mg while soil chemical properties of pH, K, Na decreased. Two times application of livestock liquid fertilizer treatment improved soil chemical properties pH, N total, Ca, Mg and saturation bases. As for solid waste, one time treatment increased chemical properties of pH, C organic, N total, Ca and saturation of the base. The two times treatment could improve soil chemical properties of pH, N. total, P, Ca, Mg, base number and base saturation. Liquid waste fertilizer also found to provide significant effect on plant height and coffee plants quality. Additionally, (3) solid waste (compost) was found to have a significant effect on plant height, plant height rate and number of buds.
"RÊVE (Romantic Europe: The Virtual Exhibition): Romantic Authorship.” : A Review Essay
Authors: Rhodes Alice
Published: January 2021

A review essay by European Romanticisms in Association Alice Rhodes on the virtual exhibition "Romantic Authorship", discussing its principles and aims.
Effect of Internet-Based Rehabilitation Programs on Improvement of Pain and Physical Function in Patients with Knee Osteoarthritis: Systematic Review and Meta-analysis of Randomized Controlled Trials (Preprint)
Authors: Xie Su-Hang , Wang Qian , Wang Li-Qiong , Wang Lin , Song Kang-Ping , He Cheng-Qi
Published: January 2021

BACKGROUND

Osteoarthritis (OA) is a chronic, debilitating, and degenerative joint disease. However, it is difficult for patients with knee OA to access conventional rehabilitation when discharging from the hospital. Internet-based rehabilitation is one of the promising telemedicine strategies to provide a means combining monitoring, guidance, and treatment for patients with knee OA.

OBJECTIVE

The aim of this study was to conduct a systematic review and meta-analysis for assessing the effect of internet-based rehabilitation programs on pain and physical function in patients with knee OA.

METHODS

Keywords related to knee OA and internet-based rehabilitation were systematically searched in the Web of Science, MEDLINE, EMBASE, CENTRAL, Scopus, PEDro (Physiotherapy Evidence Database), CNKI, SinoMed, and WANFANG databases from January 2000 to April 2020. Only randomized controlled trials were included. The authors independently screened the literature. The main outcome measures were focused on pain and physical function. A meta-analysis was performed on the collected data. Review Manager (RevMan, version 5.3) was used for all analyses.

RESULTS

The systematic review identified 6 randomized controlled trials, 4 of which were included in the meta-analysis, comprising a total of 791 patients with knee OA. The meta-analysis with the fixed-effects model showed that the internet-based rehabilitation programs could significantly alleviate the osteoarthritic pain for patients compared with conventional rehabilitation (standardized mean difference [SMD] –0.21, 95% CI  −0.4 to –0.01, P=.04). No significant difference was found in the improvement of physical function in patients with knee OA compared with conventional rehabilitation within 2 to 12 months (SMD –0.08, 95% CI −0.27 to 0.12, P=.43).

CONCLUSIONS

This systematic review shows that internet-based rehabilitation programs could improve the pain but not physical function for patients with knee OA. However, there was a very small number of studies that could be included in the review and meta-analysis. Thus, further studies with large sample sizes are warranted to promote the effectiveness of internet-based rehabilitation and to develop its personalized design.
Cost-effectiveness of a Telemonitoring Program for Patients With Heart Failure During the COVID-19 Pandemic in Hong Kong: Model Development and Data Analysis (Preprint)
Authors: Jiang Xinchan , Yao Jiaqi , You Joyce Hoi-Sze
Published: January 2021

BACKGROUND

The COVID-19 pandemic has caused patients to avoid seeking medical care. Provision of telemonitoring programs in addition to usual care has demonstrated improved effectiveness in managing patients with heart failure (HF).

OBJECTIVE

We aimed to examine the potential clinical and health economic outcomes of a telemonitoring program for management of patients with HF during the COVID-19 pandemic from the perspective of health care providers in Hong Kong.

METHODS

A Markov model was designed to compare the outcomes of a care under COVID-19 (CUC) group and a telemonitoring plus CUC group (telemonitoring group) in a hypothetical cohort of older patients with HF in Hong Kong. The model outcome measures were direct medical cost, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratio. Sensitivity analyses were performed to examine the model assumptions and the robustness of the base-case results.

RESULTS

In the base-case analysis, the telemonitoring group showed a higher QALY gain (1.9007) at a higher cost (US $15,888) compared to the CUC group (1.8345 QALYs at US $15,603). Adopting US $48,937/QALY (1 × the gross domestic product per capita of Hong Kong) as the willingness-to-pay threshold, telemonitoring was accepted as a highly cost-effective strategy, with an incremental cost-effective ratio of US $4292/QALY. No threshold value was identified in the deterministic sensitivity analysis. In the probabilistic sensitivity analysis, telemonitoring was accepted as cost-effective in 99.22% of 10,000 Monte Carlo simulations.

CONCLUSIONS

Compared to the current outpatient care alone under the COVID-19 pandemic, the addition of telemonitoring-mediated management to the current care for patients with HF appears to be a highly cost-effective strategy from the perspective of health care providers in Hong Kong.
Identifying Enablers of Participant Engagement in Clinical Trials of Consumer Health Technologies: Qualitative Study of Influenza Home Testing (Preprint)
Authors: Dharanikota Spurthy , LeRouge Cynthia M , Lyon Victoria , Durneva Polina , Thompson Matthew
Published: January 2021

BACKGROUND

A rise in the recent trend of self-managing health using consumer health technologies highlights the importance of efficient and successful consumer health technology trials. Trials are particularly essential to support large-scale implementations of consumer health technologies, such as smartphone-supported home tests. However, trials are generally fraught with challenges, such as inadequate enrollment, lack of fidelity to interventions, and high dropout rates. Understanding the reasons underlying individuals’ participation in trials can inform the design and execution of future trials of smartphone-supported home tests.

OBJECTIVE

This study aims to identify the enablers of potential participants’ trial engagement for clinical trials of smartphone-supported home tests. We use influenza home testing as our instantiation of a consumer health technology subject to trial to investigate the dispositional and situational enablers that influenced trial engagement.

METHODS

We conducted semistructured interviews with 31 trial participants using purposive sampling to facilitate demographic diversity. The interviews included a discussion of participants’ personal characteristics and external factors that enabled their trial engagement with a smartphone-supported home test for influenza. We performed both deductive and inductive thematic analyses to analyze the interview transcripts and identify enabler themes.

RESULTS

Our thematic analyses revealed a structure of dispositional and situational enablers that enhanced trial engagement. Situationally, clinical affiliation, personal advice, promotional recruitment strategies, financial incentives, and insurance status influenced trial engagement. In addition, digital health literacy, motivation to advance medical research, personal innovativeness, altruism, curiosity, positive attitude, and potential to minimize doctors’ visits were identified as the dispositional enablers for trial engagement in our study.

CONCLUSIONS

We organized the identified themes for dispositional and situational enablers of trial engagement with a smartphone-supported home test into a research framework that can guide future research as well as the trial design and execution of smartphone-supported home tests. We suggest several trial design and engagement strategies to enhance the financial and scientific viability of these trials that pave the way for advancements in patient care. Furthermore, our study also offers practical strategies to trial organizers to enhance participants’ enrollment and engagement in clinical trials of these home tests.

CLINICALTRIAL
Tweet Topics and Sentiments Relating to COVID-19 Vaccination Among Australian Twitter Users: Machine Learning Analysis (Preprint)
Authors: Kwok Stephen Wai Hang , Vadde Sai Kumar , Wang Guanjin
Published: January 2021

BACKGROUND

COVID-19 is one of the greatest threats to human beings in terms of health care, economy, and society in recent history. Up to this moment, there have been no signs of remission, and there is no proven effective cure. Vaccination is the primary biomedical preventive measure against the novel coronavirus. However, public bias or sentiments, as reflected on social media, may have a significant impact on the progression toward achieving herd immunity.

OBJECTIVE

This study aimed to use machine learning methods to extract topics and sentiments relating to COVID-19 vaccination on Twitter.

METHODS

We collected 31,100 English tweets containing COVID-19 vaccine–related keywords between January and October 2020 from Australian Twitter users. Specifically, we analyzed tweets by visualizing high-frequency word clouds and correlations between word tokens. We built a latent Dirichlet allocation (LDA) topic model to identify commonly discussed topics in a large sample of tweets. We also performed sentiment analysis to understand the overall sentiments and emotions related to COVID-19 vaccination in Australia.

RESULTS

Our analysis identified 3 LDA topics: (1) attitudes toward COVID-19 and its vaccination, (2) advocating infection control measures against COVID-19, and (3) misconceptions and complaints about COVID-19 control. Nearly two-thirds of the sentiments of all tweets expressed a positive public opinion about the COVID-19 vaccine; around one-third were negative. Among the 8 basic emotions, trust and anticipation were the two prominent positive emotions observed in the tweets, while fear was the top negative emotion.

CONCLUSIONS

Our findings indicate that some Twitter users in Australia supported infection control measures against COVID-19 and refuted misinformation. However, those who underestimated the risks and severity of COVID-19 may have rationalized their position on COVID-19 vaccination with conspiracy theories. We also noticed that the level of positive sentiment among the public may not be sufficient to increase vaccination coverage to a level high enough to achieve vaccination-induced herd immunity. Governments should explore public opinion and sentiments toward COVID-19 and COVID-19 vaccination, and implement an effective vaccination promotion scheme in addition to supporting the development and clinical administration of COVID-19 vaccines.
The Influence of Carbon Tax on the Feasibility of Industrial Project: A Case Study of Heat Exchanger Replacement at PT Kaltim Methanol Industri, Indonesia
Authors: Dewanatan Wingo Wira , Adiputra Muhammad Kurniawan , Putro Imam Karfendi , Hartanto Soni , Kristanto Jonas , Azis Muhammad Mufti
Published: January 2021

Petrochemical industries have faced growing pressure to decrease their carbon emission from direct and indirect sources. This work aims to demonstrate a carbon tax’s introduction to a feasibility study on the heat exchanger (HE) replacement project at PT Kaltim Methanol Industri, Indonesia. The project was aimed to avoid methanol release as much as 48.88 MT/year. The release of methanol can also be associated with CO2 emission with an emission factor of 0.6 ton CO2e/ton methanol. Here, we investigated the influence of inclusion and exclusion of carbon tax to monetize the CO2 release. From the project investment point of view, carbon tax inclusion is expected to increase the cost-saving. Introduction of the carbon tax as high as 10 USD/ton CO2e with 5% annual increase gives IRR value of 7.06% with Payout Time (PoT) of ca. 11 years. The IRR value without carbon tax scenario is 6.68 % with the same range of PoT. Hence, the inclusion of carbon tax may increase the feasibility of the project. This work has demonstrated the positive role of the carbon tax to increase the feasibility of a project which inlines with the national initiatives to curb the CO2 emission from chemical industries. It is also worth noting that introduction of carbon tax should be accompanied by a reorganization of government incentives, including several financial policies to create a conducive atmosphere for investors in Indonesia.
The Effect of Based Services Medication Therapy Management on Treatment Adherence and Quality of Life of Diabetes Mellitus Patients
Authors: Malina Rachma , Yasin Nanang Munif , Wiedyaningsih Chairun
Published: January 2021

Diabetes mellitus is a chronic metabolic disorder that is characterized by hyperglycemia. Diabetes mellitus need appropriate therapeutic management, because it can cause complications. On of the services that can do to improve diabetes control is Medication Therapy Management (MTM). MTM is a new service that will help pharmacist to improve patient adherence and quality of life. This study aims to determine the effect of based services MTM on treatment adherence and quality of life in patients with diabetes mellitus. This study was an experimental study using a quasi-experimental with one group pretest and posttest design which was conducted in Tegalrejo, Jetis and Gedontengen Health Center Yogyakarta City. Variables measured were medication adherence using the Morisky-Green Levine Medication Adherence Scale (MGLS) questionnaire and quality of life using Diabetes Quality of Life Clinical Trial Questionnaire (DQLCTQ) before and after MTM services. The effect of MTM on medication adherence was analyzed using Wilcoxon test and the effect of MTM on quality of life using Paired T-Test. The patients participate in this study were 20 people, with average score of adherences before application of MTM was 2.20±0.410 to 1.80±0.616 after the application of MTM (P=0.005) and the average of the patient's quality of life was 73.82±7.918, increased to 76.42±5,623 after MTM service (P=0.033). Statistically mean, there is a difference in adherence and quality of life before and after MTM services. Therefore, it can be concluded that MTM-based services performed by pharmacists have a significant effect on improving medication adherence and quality of life for DM patients. Moreover, it can facilitate monitoring patient therapy, and identification of problems related to the treatment.
Binomial Count Information: How Do the Usual Approximations Fare?
Authors: Lusk Edward J.
Published: January 2021

Focus Decision-making is often aided by examining False Positive Error-risk profiles [FPEs]. In this research report, the decision-making jeopardy that one invites by eschewing the Exact factorial-binomial Probability-values used to form the FPEs in favor of: (i) Normal Approximations [NA], or (ii) Continuity-Corrected Normal Approximations [CCNA] is addressed. Results Referencing an audit context where testing sample sizes for Re-Performance & Re-Calculation protocols are, by economic necessity, in the range of 20 to 100 account items, there are indications that audit decisions would benefit by using the Exact Probability-values. Specifically, using a jeopardy-screen of ±2.5% created by benchmarking the NA & the CCNA by the Exact FPEs, it is observed that: (i) for sample sizes of 100 there is little difference between the Exact and the CCNA FPEs, (ii) almost uniformly for both sample extremes of 20 and 100, the FPEs created using the NA are lower and outside the jeopardy screen, finally (iii) for the CCNA-arm for sample sizes of n = 20, only sometimes are the CCNA FPEs interior to the jeopardy screen. These results call into question not using the Exact Factorial Binomial results. Finally, an illustrative example is offered of an A priori FPE-risk Decision-Grid that can be parametrized and used in a decision-making context.
Variedades del capitalismo: Una teoría alterna a la idea hegemónica de la globalización
Authors: Sandoval Robayo Mary Luz
Published: January 2021

Este artículo expone la disputa teórica que la ciencia política propone contra la teoría de la convergencia más conocida en los campos económico y sociológico como globalización, a través de la teoría de Variedades del Capitalismo (Varieties of Capitalism, VoC) y sus derivaciones. El método utilizado es el análisis teórico comparativo con el fin de establecer las características de los modelos de bienestar y la relación capital/trabajo según ésta. Se analizan los alcances y limitaciones de las teorías de variedades del capitalismo a partir del institucionalismo histórico, el path dependence y el rational choice, para determinar su nivel de estatismo y capacidad de comprensión del cambio y se reseñan algunas de las derivaciones más actuales de dicha teoría.
O SUPERANTÍTESE - OBSERVAÇÕES SOBRE A CONDIÇÃO RETÓRICA DO SUPERMAN
Authors: Viegas Rafael
Published: January 2021

O artigo é uma breve investigação dos problemas gerados pela disposição antitética dos elementos formadores do mito de origem do Superman. Apesar de se tratar de uma narrativa tardia, ela acabou dando consistência a uma interface dúbia do herói: uma excepcional redenção do americano médio.
Editorial: A multidisciplinary insight into the organizational behavior research
Authors: Corvino Antonio
Published: January 2021

Over the last months, the COVID-19 pandemic represented a disruptive phenomenon, in terms of health and socio-economic implications. Organizations and human capital are thereon tackling effects ascribable to a real structural change. In particular, each effect (i.e., smart working, the ways of knowledge accumulation and sharing, etc.) is significantly conditioning their life cycle. Therefore, the enterprise is facing new challenges, such as the refreshing of the corporate governance path, the rethinking of the business model (Caputo, Pizzi, Pellegrini, & Dabić, 2020; Pizzi, Corbo, & Caputo, 2020; Rosato, Caputo, Valente, & Pizzi, 2021) and so on, which are described by some papers published in the present issue.
A silent trio: giant descending aortic aneurysm combined with coarctation and persistent left brachiocephalic truncus
Authors: Basho Maksim , Nunci Deniona , Vyshka Gentian , Prifti Edvin
Published: January 2021

We report the case of an undiagnosed descending aortic aneurysm,
combined with coarctation and persistent left brachiocephalic truncus in
a 59-years old male. This case underscores the increased necessity for
aortic imaging while facing a poorly controlled hypertension,
erroneously considered as of essential origin.
The role of echocardiography in predicting technical problems and complications of transvenous leads extractions procedures
Authors: Nowosielecka Dorota , Jacheć Wojciech , Polewczyk Anna , Tułecki Łukasz , Kleinrok Andrzej , Kutarski Andrzej
Published: January 2021

Introduction Transesophageal echocardiography (TEE) is a useful tool in
preoperative observation of patients undergoing transvenous leads
extraction (TLE) due to complications associated with implanted devices.
Echocardiographic phenomena may determine the safety of the procedure.
Methods and results Data from 936 transesophageal examinations (TEE)
performed at a high volume center in patients awaiting TLE from 2015 to
2019 were assessed. TEE revealed a total of 1156 phenomena associated
with the implanted leads in 697 (64.85%) patients, including:
asymptomatic masses on endocardial leads (AMEL) (58.65%), vegetations
(12,73%), fibrous tissue binding the lead to the vein or heart wall
(33.76%), lead-to-lead binding sites (18.38%), excess lead loops
(19.34%), intramural penetration of the lead tip (16.13%),
lead-dependent tricuspid dysfunction (LDTD) (6.41%). Risk factors for
technical difficulties during TLE in multivatiate analysis were: fibrous
tissue binding the lead to atrial wall (OR=1.738; p<0.05), to
right ventricular wall (OR=2.167; p<0.001), lead-to-lead
binding sites (OR=1.628; p<0.01) and excess lead loops
(OR=1.488; p<0.05). Lead-to-lead binding sites increased
probability of major complications (OR=3.034; p<0.05).
Presence of fibrous tissue binding the lead to the superior vena cava
(OR=0.296; p<0.05), right atrial wall (OR=323;
p<0.05) and right ventricular wall (OR=0.297;
p<0.05) reduced the probability of complete procedural
success, whereas fibrous tissue binding the lead to the tricuspid
apparatus decreased the probability of clinical success (OR=0.307;
p<0.05), Conclusions: Careful preoperative TEE evaluation of
the consequences of extended lead implant duration (enhanced fibrotic
response) increases the probability of predicting the level of
difficulty of TLE procedures, their efficacy and risk of major
complications.
Miscellaneous Burns and Related Conditions
Authors: Gibran Nicole S. , Brown David A
Published: January 2021

This review covers the recognition and management of electrical injury, chemical burns, injury from chemicals of mass destruction, cold injury, toxic epidermal necrolysis (TEN), and ionizing radiation burns. Electrical injuries can be divided into low-voltage burns, high-voltage burns, and super-high-voltage burns. Chemical burns are commonly caused by strong alkalis or acids and less commonly by anhydrous ammonia. Chemicals used in war include napalm, white phosphorus, and vesicants such as mustard gas, lewisite, and phosgene. Cold injuries result either from direct freezing (frostbite) or from more long-term exposure to an environment just above freezing (chilblain, pernio, trench foot). TEN, though not a burn, can cause similar tissue damage and is managed similarly in a number of respects. Ionizing radiation burns may be encountered in three settings: (1) deliberate or accidental exposure to radiation in a hospital, laboratory, or industrial environment (by far the most common setting); (2) failure of a nuclear power plant (as at Chernobyl); and (3) nuclear explosion.
This review contains 12 figures, 5 tables, and 122 references.
Identifikasi Peptida Bioaktif dari Protein Kedelai sebagai Inhibitor Enzim α-glukosidase untuk Kandidat Antidiabetes
Authors: Fakih Taufik Muhammad , Dewi Mentari Luthfika
Published: January 2021

Diabetes mellitus is one of the endocrine metabolic disorders that has caused morbidity and mortality worldwide. Α-glucosidase inhibitor which plays an important role in carbohydrate metabolism is needed to avoid postprandial hyperglycemia. A bioactive peptide derived from soy protein was chosen as an alternative treatment for diabetes because of its therapeutic potential. Several bioactive peptides have been shown to inhibit the α-glucosidase enzyme, such as the bioactive peptide LLPLPVLK, SWLRL, and WLRL. This study aims to identify and evaluate molecular interactions that occur between bioactive peptide molecules and α-glucosidase enzyme macromolecules using protein-peptide docking methods through in silico. Bioactive peptide sequencing was first modeled using the PEP-FOLD software. The best conformation was chosen for an interaction study of the α-glucosidase enzyme macromolecule using HPEPDock software. Further exploration was carried out on the molecular interactions formed using BIOVIA Discovery Studio 2020 software. Based on the results of molecular docking, the WLRL bioactive peptide has the best affinity against the α-glucosidase enzyme, with a binding free energy value of −748.12 kJ/mol. Therefore, the bioactive peptide is predicted to be a suitable candidate for the α-glucosidase enzyme inhibitor.
Pemberitahuan Retraksi Artikel: Pengaruh Pemberian Terapi Tambahan Curcuma longa dan Boswellia serrata pada NSAID Terhadap Aktivitas Fungsional pada Pasien Osteoarthritis
Authors: Pharmacon Editor
Published: January 2021

Pemberitahuan retraksi artikel: Pengaruh Pemberian Terapi Tambahan Curcuma longa dan Boswellia serrata pada NSAID Terhadap Aktivitas Fungsional pada Pasien Osteoarthritis The Effect of Additional Therapy of Curcuma longa and Boswellia serrata on NSAIDs on Functional Activity in Osteoarthritis PatientsRizaldy Taslim Pinzon1*, Jessica Herwanto21Departemen Neurologi, Fakultas Kedokteran, Universitas Kristen Duta Wacana, Yogyakarta, Indonesia2Mahasiswa Program Studi Farmasi Fakultas Farmasi Universitas Sanata Dharma, Yogyakarta, IndonesiaArtikel ini telah diretraksi dari Pharmacon: Jurnal Farmasi Indonesia 17(2), 121-132, Desember 2020, atas permintaan dari penulis dan persetujuan dari dewan editor.
Optimasi Masker Gel Peel-Off Ekstrak Etanolik Daun Sirih (Piper Betle L.) dengan Kombinasi Carbomer dan Polivinil Alkohol
Authors: Setiyadi Gunawan , Qonitah Annisa
Published: January 2021

Betel leaf (Piper betle L.) is a plant that has potential as a source of natural antioxidants. The purpose of this study was to determine the effect of the combination of carbomer and PVA on the homogeneity, dispersibility, adhesion, viscosity, dry time, elasticity and pH of the gel peel-off mask preparation; obtain the optimum formula and determine the antioxidant activity of the optimum formula. Extraction of betel leaf was carried out using the maceration method with 96% ethanol as a solvent. The experimental design was made using Design Expert software version 11 with the Simplex Lattice Design (SLD) method with the optimized components being carbomer and PVA. The response of physical properties in the form of spreadability, adhesion, pH, viscosity, dry time, and elasticity of each formula is measured and the measurement data is processed with Design Expert software to determine the optimum formula based on predetermined criteria. The verification dosage form is made based on the optimum formula composition produced. The response of the optimum physical properties of the prediction formula was compared with the results of the verification preparation with the One sample t-test. The yield of thick betel leaf extract in this study was 20.26%. The optimum formula has homogeneous characteristics with a distinctive odor of dark green betel leaf and semi-solid form, spreadability 49.25 ± 0.29 cm2, adhesion 4.77 ± 0.22 seconds, pH 7.26 ± 0.119, viscosity 763 ± 12.47 dPas, drying time 29.68 ± 0.52 minutes, elasticity 1.05 ± 0.04%. The antioxidant activity of betel leaf ethanolic extract has an IC50 value of 7.62 µg / mL and the optimum formula has an IC50 value of 111.25 µg / mL.
Kajian Potensi Interaksi Obat pada Pasien Gagal Ginjal Rawat Jalan RS “X” Kota Cirebon
Authors: Hidayati Nur Rahmi , Susilo Rinto , Anggraeni Mila
Published: January 2021

Drug interactions are one of part of Drug Related Problem (DRP) which significantly affect the development patient health. This study aims to determine the characteristics of kidney failure patients (age and genitals), an overview of the number of potential drug interactions, an overview of the types and amounts of other drugs interacting, and the severity of drug interactions in kidney failure patients in the Outpatient of “X” Hospital Cirebon City. This study involves 126 patient prescriptions. This type of research is a non-experimental research with descriptive analysis method, and using data collection methods with prospective random sampling technique in the Outpatient of RS “X” Cirebon. The results of the research from 126 samples obtained showed that the characteristics of Kidney Failure patients were predominantly male as many as 64 people (50.79%), the most age was in the age range 61-70 years as many as 38 people (30.16%). drug interactions 78 sheets of prescriptions (61.9%), the most severity of drug interactions was the strict / significant monitoring of 128 events (64.65%), the average of drug interactions per prescription sheet was 3 interactions, the type and number of the most interacting drug was furosemide + folic acid with 32 potential interactions (41.02%).
Cabaran Komunikasi dalam Pengajaran Pendidikan Islam kepada Murid Kurang Upaya Pendengaran
Authors: DZULKIFLI IZULI , SUHID ASMAWATI , MOHD FAKHRUDDIN FATHIYAH , AHMAD NOR ANIZA
Published: January 2021

Pupils with hearing impairment have their own form of communication. They also get the opportunity to learn Islamic Education subject at the primary level in the Special Primary Schools (SPK) and Special Education Integrated Programme (PPKI). Islamic Education subject has six main areas namely al-Quran, Akidah, Ibadah, Akhlak, Sirah and Jawi. Since the level of hearing and speech impairment of the pupils with special needs are limited, it is essential that the communication aspect in teaching should be taken into the teachers’ consideration. The objective of this study is to explain the method of communication used by the teachers as well as the challenges in communication during teaching Islamic Education subject to pupils with hearing impairment. This study utilized the qualitative approach in the form of a case study, using the interview technique and document analysis to obtain data. The findings showed there were inconsistencies in the teachers’ communication in delivering the Islamic Education subject to the pupils. Lack of proper codes or signs related to Islamic Education and lack of skills in using sign language are the reasons for inconsistencies in the teachers’ communication in delivering the subject to the pupils.
Perilaku Kesehatan Pada Masa Pandemi Covid-19
Authors: Prastiwi Andar , Darmawan Diaz Restu , Efriani Efriani
Published: January 2021

Kemunculan Pandemi virus Covid-19 diawal tahun 2020 membawa pengaruh besar hampir seluruh Dunia, tidak terkecuali Indonesia. Beragam kebijakan dan respon telah diambil oleh pemerintah dan wilayah pusat untuk menekan pencegahan penyebaran virus. Termasuk juga pada kawasan perdesaan yang mengambil tindakan pencegahan penyebaran virus di wilayahnya dengan sumber informasi yang minim, salah satunya membangun pos penjagaan di pintu masuk desa. Fokus penelitian ini adalah melihat perubahan perilaku yang dilakukan orang-orang Desa Suka Jaya Kecamatan Ledo Kabupaten Bengkayang dalam menyikapi penyebaran virus Covid-19. Penelitian ini menggunakan sudut pandang kajian antropologi kesehatan dengan menggunakan teori perilaku kesehatan Nico S. Kalangie. penelitian dilakukan dengan metode etnografi, dengan sudut pandang emik dan etik. Hasil penelitian menunjukkan bahwa adanya kesadaran masyarakat untuk membuat pos pemeriksaan secara gotong-royong dan memeriksa orang luar yang masuk ke desa, dann munculnya perubahan perilaku mereka dengan menjaga jarak dan menggunakan masker.
Tradisi Ngihok Pada Masyarakat Desa Pulau Tengah Kerinci Jambi
Authors: Eryanto Eryanto , Fitriani Erda
Published: January 2021

Artikel ini bertujuan untuk menjelaskan fungsi tradisi ngihok bagi masyarakat Desa Pulau Tengah, Kabuoaten Kerinci Provinsi Jambi. Tradisi ngihok merupakan suatu kegiatan yang berupa pengumuman ataupun penyampaian informasi dari depati ninik mamak yang disampaikan oleh lingang kepada masyarakat dengan tujuan untuk memberikan informasi terkait tentang kegiatan-kegiatan adat, peringatan hari-hari besar, gotong royong, upacara adat, dan lain sebagainya. Tradisi ini sudah turun-temurun dilakukan oleh masyarakat setempat. Penelitian ini merupakan penelitian kualitatif yang berusaha menghasilkan data deskriftif dengan tipe penelitian etnografi. Pengumpulan data dilakukan dengan cara observasi partisivan dan wawancara mendalam. Data dianalisa dengan menggunakan teori yang dikemukakan oleh EE. Evan Pritchard. Hasil penelitian menunjukkan bahwa, terdapat beberapa fungsi ngihok bagi masyarakat, yaitu; memperkuat solidaritas antar kelompok masyarakat, memperkuat indentitas adat, sebagai alat komunikasi, dan sebagai pembeda perintah raja dengan kepala desa.
Peningkatan Motivasi dan Hasil Belajar Matematika Tentang Pecahan Melalui Model Find The Fib Pada Siswa Sekolah Dasar
Authors: Adianto Samsul
Published: January 2021

Penelitian ini merupakan penelitian tindakan kelas yang bertujuan untuk meningkatkan motivasi dan hasil belajar matematika tentang pecahan melalui model Find The Fib pada siswa kelas 5C di Sekolah Dasar SDN 004 Samarinda Ulu. Latar belakang penelitian ini adalah ditemukan permasalahan belajar pada kelas 5C khususnya pada motivasi dan hasil belajar matematika. Subyek penelitian ini adalah seluruh siswa kelas 5C. Penelitian dilaksanakan sebanyak tiga siklus, yang terdiri 3 kali pertemuan dalam setiap siklusnya. Teknik pengumpulan data berupa lembar observasi dan hasil belajar siswa. Data yang diperoleh disajikan dalam rata-rata dan persentase. Dari hasil  analisis ketuntasan belajar siswa mengalami peningkatan, siklus 1 (8%), siklus 2 (70%), siklus 3 (100%). Berdasarkan hasil penelitian disimpulkan bahwa melalui model Find The Fib dapat meningkatkan motivasi dan hasil belajar matematika kelas 5C. Dengan variasi pengajaran yang unik dan berkelompok, pembelajaran menjadi aktif, suasana kelas menjadi lebih hidup, menciptakan pengalaman belajar baru bagi siswa, sehingga menimbulkan gairah belajar serta motivasi belajar dalam diri siswa untuk menyukai matematika.