bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluating levee setback distance for the co-benefits of groundwater recharge and riparian ecosystem function
Authors: Calderwood Andrew J. , Rodriguez Alisha , Foglia Laura , Dahlke Helen E.
Published: December 2024

Constructed levees are designed to protect anthropogenic developments from destructive flooding events, but their construction has reduced groundwater recharge, increased flood risk severity under levee failure, increased the incision of river channels, and deteriorated riparian habitat. To reverse these impacts, levee setbacks are often designed to reduce flood risk and provide the opportunity to restore ecohydrological function, while groundwater recharge is rarely considered because it may require relatively detailed groundwater system analysis. In this study, we evaluated 100 heterogeneous hydrogeology realizations to estimate recharge with high-conductivity pathways (HCPs) under varying flood flows for a range of levee setback distances to identify the trade-offs in groundwater recharge and floodplain habitat. We find that on a regional scale, total recharge potential increases with setback distance, with the largest gains up to 1,400 m where there are outcropping HCPs and sufficient flow to inundate more of the setback area. In contrast, the recharge per unit area (i.e., the average daily recharge divided by setback area) generally decreases as levee setback increases, but there are local increases in the recharge per unit area at 1,400 m where HCP recharge may sufficiently offset the larger area. There is a median 10%–40% reduction in peak streamflow with increasing setback distance, which would aid flood risk reduction, but the increased area leads to decreasing depth due to flow losses and increased spreading of flood water. Ultimately, the decision for levee setback distance will depend on local conditions and management goals, as we find that increasing recharge will reduce the floodplain depth necessary for ecosystem function. Our results highlight the opportunity to consider groundwater recharge benefits in levee setback feasibility studies in semi-arid regions impacted by floods and groundwater overdrafts so that setback distance designs can achieve integration of flood risk reduction, riparian habitat, and groundwater recharge.
Speckle tracking ultrasound as a new tool to predict the weaning outcome of mechanical ventilation patients: a prospective observational study
Authors: Li Rui , Zhou Yao , Chen Wan , Lyu Liwen , Qiu Guozheng , Pan Chunxi , Tang Yutao
Published: December 2024

Introduction

Speckle tracking ultrasound is a novel technique for evaluating diaphragm movement, yet its guidance in weaning mechanically ventilated patients remains unclear. In this study, we assessed diaphragmatic function using speckle tracking ultrasound and guided the weaning process.

Methods

A total of 86 mechanically ventilated patients were included and divided into successful or failed weaning groups. Diaphragmatic function was assessed using speckle tracking ultrasound, M-ultrasound diaphragm excursion (DE), and diaphragmatic twitch force (DTF) after 30 min spontaneous breathing trial (SBT). The diagnostic performance of these indicator in predicting weaning outcomes was also evaluated.

Results

In this study, a total of 86 patients completed the follow-up for weaning outcomes, with 35 cases of weaning failure and 51 cases of successful weaning. Logistic regression analysis identified whole strain (p = 0.037) and DE (p = 0.004) as independent predictors of weaning outcome. Receiver operating characteristic (ROC) curve showed that the strain threshold for Costal Diaphragm (Dlcos) was −9.836, Area Under the Curve (AUC) value was 0.760, the predictive specificity for weaning failure was 72.5%, and the sensitivity was 80%. DE value exceeding 1.015 cm had an AUC value of 0.785, noting that DE value had a high specificity (90.2%) for predicting successful weaning, but a lower sensitivity (60%). After merging, the AUC of whole strain and DE was 0.856, and the sensitivity (80%) and specificity (80.4%) were more balanced compared to using DE alone.

Conclusion

The findings of this study demonstrate the feasibility of using speckle tracking ultrasound to assess diaphragmatic function in mechanically ventilated patients. The combined utilization of whole strain and DE provides a more precise evaluation of diaphragmatic function in ICU patient, which may improve patient outcome.
Neuroblastoma response to RAS-MAPK inhibitors and APR-246 (eprenetapopt) co-treatment is dependent on SLC7A11
Authors: Mlakar Vid , Oehme Ina , Lesne Laurence , Najafi Sara , Ansari Marc , Gumy-Pause Fabienne
Published: December 2024

Background

We previously demonstrated that APR-246 (eprenetapopt) could be an efficient treatment option against neuroblastoma (NB), the most common pediatric extracranial solid tumor. APR-246’s mechanism of action is not completely understood and can differ between cell types. Here we investigate the involvement of well-known oncogenic pathways in NB’s response to APR-246.

Methods

A proteome profiler kinase assays and western blot analysis were used to identify the molecular pathways involved in the responses to APR-246. Bulk ATP levels were used to determine the viability of cells and the IC50 for APR-246. Cystine-FITC was used to measure the cellular uptake of cysteine. PmRNA5 was used to activate ERK1/2 and pshRNA1 was used to silence HSP27. An IMR-32 xenograft zebrafish embryo model was used to assess APR-246 and sulfasalazine efficacy in vivo.

Results

After APR-246 treatment, the most deregulated signaling protein identified was ERK1/2, an end-point kinase of the RAS-MAPK pathway. Induction of phospho-ERK1/2 resulted in increased glutathione (GSH) levels, increased cystine uptake, and increased resistance of NB cells to APR-246. Using ERK1/2 inhibitors in combination with APR-246, we were able to categorize cells into synergistic and antagonistic groups. After co-treatment, these two groups differ by their levels of SLC7A11 and Hsp27 phosphorylation, cystine uptake, and BIM expression. Using erastin and sulfasalazine, both inhibitors of SLC7A11 and activators of ferroptosis, we were able to reverse the antagonistic effects of ERK1/2 inhibitors and demonstrate a strong synergistic action in vitro and in vivo in zebrafish models.

Conclusions

These results demonstrated a pivotal role of the RAS-MAPK pathway in the NB cellular response to APR-246 via the modulation of intracellular concentrations of GSH and the transport of cystine through SLC7A11, phosphorylation of Hsp27, and programmed cell death. Combining APR-246 with RAS-MAPK pathway inhibitors can, in some cases, lead to antagonistic action, which can be reversed by combining APR-246 with the clinically approved drug sulfasalazine.
Recurrent abdominal pain in children in Wuhu, China was not associated with Helicobacter pylori infection, but associated with <1 h/day physical activity and academic stress
Authors: Bai Xiaohui , Cao Huiru , Zhu Liuming , Wu Xiaomin , Wang Guixiang , Yu Wenchao , Gu Yong
Published: December 2024

Background

Recurrent abdominal pain (RAP) is one of the most common gastrointestinal disorders in children. The aim of this study was to investigate the relationship between RAP and Helicobacter pylori infection in children in Wuhu, China as well as the risk factors for Helicobacter pylori infection in this region.

Materials and methods

In this cross-sectional survey, we randomly selected children aged 6–17 years who underwent health examinations at three public hospital examination centers in Wuhu city, Anhui Province, China. Helicobacter pylori infection was assessed by a 13C-urea breath test (UBT) kit. Questionnaires were custom designed to obtain data on behavioral, sociodemographic, and environmental characteristics, and to investigate the relationship between RAP and Helicobacter pylori infection in children.

Results

A total of 1,187 children aged 6–17 years were enrolled, among these children, 182 were diagnosed with RAP, with an incidence rate of 15.3%. A total of 266 children were infected with Helicobacter pylori, with an infection rate of 22.4%. Multivariate regression analysis revealed that physical activity for <1 h/day and academic stress are associated with RAP in children, whereas Helicobacter pylori infection, age, sex, body mass index (BMI), and fast-food consumption are not associated with RAP in children. Our research also found that the risk of Helicobacter pylori infection increases with age in children. Risk factors for Helicobacter pylori infection in children include left-behind children, poor hygiene habits, family history of Helicobacter pylori infection, and mother with low cultural levels.

Conclusions

Recurrent abdominal pain in children in Wuhu, China was not associated with Helicobacter pylori infection, but strongly associated with <1 h/day physical activity and academic stress.
Simultaneous quantitative screening of 53 phytochemicals from Rheum tataricum L. roots: a comparative study of supercritical CO2, subcritical ethanol, and ultrasound-assisted extraction for enhanced antioxidant, antibacterial activities, and molecular docking study
Authors: Amangeldinova Madina , Ersatır Mehmet , Necip Adem , Yilmaz Mustafa Abdullah , Cimentepe Mehmet , Kudrina Nataliya , Terletskaya Nina V. , Ozturk Cimentepe Ozge , Yildirim Metin
Published: December 2024

In this study, Rheum tataricum L. extracts were obtained using various green extraction techniques, including supercritical CO2, subcritical ethanol, and ultrasound-assisted extraction, each performed under optimized parameters. The phytochemical content of the extracts was analyzed using the LC-MS/MS technique, quantifying 53 phytochemicals. Additionally, the in vitro antioxidant properties and antibacterial activities of the extracts were evaluated against Staphylococcus aureus and Enterococcus faecalis as gram-positive bacteria, and Escherichia coli and Pseudomonas aeruginosa as gram-negative bacteria. According to the results, the extracts were rich in catechin, epicatechin, cyranoside, and chlorogenic acid. Extracts obtained via ultrasonic extraction demonstrated stronger antioxidant properties. The IC50 values for the DPPH radical scavenging activity of obtained extracts ranged between 0.0173 mg/mL and 0.0400 mg/mL. The highest total phenolic content was found in the UAE-M-4h extract (213.44 mg GAE/mL). The extracts prepared with UAE-MeOH-2h-4h, UAE-EtOH-2h-4h, Sbc-EtOH-E-140-60-80, Sc-90 atm, and Sc-400 atm showed antibacterial activity against both Gram-positive and Gram-negative bacteria at varying rates (MIC range: 31.25 to 250 μg/mL). Based on the all results, the ultrasound assisted extraction proved superior to the other techniques. This study, utilizing three different extraction methods with varying variables such as temperature, pressure, and extraction time, has provided significant insights into which extraction method should be employed for isolating specific phytochemicals or for therapeutic purposes, based on the differing antibacterial results observed. The findings highlight the importance of selecting the appropriate extraction method depending on the target phytochemical or desired antibacterial effect in treatment applications.
Polska terminologia gramatyczna w Nowym dykcjonarzu... M.A. Trotza (1764)
Authors: Tozhyieva Vitaliia
Published: December 2024

This article presents a lexico-semantic analysis of grammatical terminology in the dictionary by M.A. Trotz Nowy dykcjonarz, to jest Mownik polsko-niemiecko-francuski (Leipzig, 1764). Trotz created an original work that had a significant impact on the dissemintion of specialist grammatical terms that have subsequently been reflected in grammar books and textbooks. In particular, the lexicographer exhibited a preference for vernacular terms, while significantly reducing the use of Latin terms. The analysis of selected specialist terms has shown that, at that stage, grammatical terminology was forming, with a search for model terminological units and a tendency for them to become stabilized.
Neuroadaptive Control of a Continuum Robot for Finger Rehabilitation
Authors: Akgun Gazi , Kaplanoglu Erkan , Erdemir Gokhan
Published: December 2024

This study has designed an easy-to-wear parallel continuum robot-based hand rehabilitation system that supports and enhances the finger’s flexion, extension, abduction, and adduction movements. The primary novelty of the proposed system lies in its ability to focus therapeutic exercises on a single joint, a feature not commonly found in existing rehabilitation robots. A kinematic model of the system was developed, and to perform both kinematic and dynamic analyses, a multibody model was constructed in the MATLAB Simulink environment. Joint angle control was implemented using a nominal controller, and to account for individual uncertainties in joint dynamics, a neuroadaptive controller was integrated with the nominal controller. This approach aims for the neural network architecture to learn these uncertainties during control iterations and incorporate them into the control, resulting in a robust controller. Thus, a model reference control approach was proposed for active and passive rehabilitation processes. The system model was tested in a simulation environment, and then all tests were repeated in the physical system. The simulation and real system results include the real system’s open-loop responses, nominal controller responses for each joint, responses, and the results for active, passive, and assistive control modes.
From Reality to Virtuality: Revolutionizing Livestock Farming Through Digital Twins
Authors: Arulmozhi Elanchezhian , Deb Nibas Chandra , Tamrakar Niraj , Kang Dae Yeong , Kang Myeong Yong , Kook Junghoo , Basak Jayanta Kumar , Kim Hyeon Tae
Published: December 2024

The impacts of climate change on agricultural production are becoming more severe, leading to increased food insecurity. Adopting more progressive methodologies, like smart farming instead of conventional methods, is essential for enhancing production. Consequently, livestock production is swiftly evolving towards smart farming systems, propelled by rapid advancements in technology such as cloud computing, the Internet of Things, big data, machine learning, augmented reality, and robotics. A Digital Twin (DT), an aspect of cutting-edge digital agriculture technology, represents a virtual replica or model of any physical entity (physical twin) linked through real-time data exchange. A DT conceptually mirrors the state of its physical counterpart in real time and vice versa. DT adoption in the livestock sector remains in its early stages, revealing a knowledge gap in fully implementing DTs within livestock systems. DTs in livestock hold considerable promise for improving animal health, welfare, and productivity. This research provides an overview of the current landscape of digital transformation in the livestock sector, emphasizing applications in animal monitoring, environmental management, precision agriculture, and supply chain optimization. Our findings highlight the need for high-quality data, comprehensive data privacy measures, and integration across varied data sources to ensure accurate and effective DT implementation. Similarly, the study outlines their possible applications and effects on livestock and the challenges and limitations, including concerns about data privacy, the necessity for high-quality data to ensure accurate simulations and predictions, and the intricacies involved in integrating various data sources. Finally, the paper delves into the possibilities of digital twins in livestock, emphasizing potential paths for future research and progress.
Are Consumers Ready to Consider Insect-Based Foods as a Sustainable Food Choice? An Application of the Extended Protection Motivation Theory to Italian Consumers
Authors: Vastola Antonella , Romano Severino , Cozzi Mario , Viccaro Mauro
Published: December 2024

Adopting sustainable food choices is crucial to mitigating the environmental impacts of food production. Insect-based foods offer a promising alternative with low resource requirements and reduced greenhouse gas emissions. This study examines the psychological factors influencing consumers’ intentions to purchase insect-based foods using an extended protection motivation theory (PMT) model that includes disgust as a critical factor. Data from 233 Italian participants were analyzed through partial least squares structural equation modeling (PLS-SEM). Results indicate that perceived response efficacy—the belief in the environmental benefits of insect consumption—and self-efficacy—confidence in one’s ability to incorporate insect-based foods—positively influence purchase intentions. However, strong aversions rooted in disgust and low intrinsic motivation present major barriers, highlighting cultural resistance to entomophagy in Western contexts. Extrinsic motivators such as social recognition, perceived costs, and perceived severity or vulnerability to environmental issues had no significant effect. The findings suggest that effective strategies should focus on reducing disgust and strengthening consumer confidence, emphasizing the environmental benefits to shift attitudes toward sustainable dietary choices.
Nano-Selenium Reduces Concentrations of Fecal Minerals by Altering Bacteria Composition in Feedlot Goats
Authors: Liu Hu , Mao Kaiyu , Peng Weishi , Degen Allan , Zuo Gang , Yang Yuanting , Han Jiancheng , Wu Qun , Wang Ke , Jiang Qinyang , Zhou Hanlin
Published: December 2024

This study examined the effect of dietary supplementation of nano-selenium (nano-Se) on the average daily gain (ADG), fecal bacteria community, and concentrations of fecal minerals and volatile fatty acids in feedlot Hainan black goats. Eighteen goats (18.6 ± 0.69 kg) were divided randomly into three groups, with each group receiving a different level of supplementary nano-Se (n = six goats per treatment) as follows: (1) 0.0 mg (CON); (2) 0.2 mg; and (3) 0.4 mg nano-Se/kg dry matter intake (DMI). The final body weight (p = 0.012) and ADG increased linearly (p < 0.01), whereas the ratio of DMI to ADG decreased linearly (p < 0.01) with increasing dietary nano-Se levels. Fecal concentrations of Se increased linearly (p < 0.001), whereas Cu (p < 0.01), Zn (p = 0.020), and Fe (p = 0.010) decreased linearly with increasing dietary nano-Se levels. The relative abundances of Treponema (p = 0.046), norank_f__norank_o__Clostridia_UCG-014 (p < 0.01), norank_ f_norank_o__RF39 (p < 0.01), Eubacterium_siraeum_group (p < 0.001), and Family_XIII_AD3011_group (p = 0.040) increased linearly, and unclassified_f__Lachnospiraceae (p < 0.001), Rikenellaceae_RC9_gut_group (p < 0.01), Eubacterium_ruminantium_group (p = 0.021), and Prevotella (p < 0.001) decreased linearly with increasing dietary nano-Se levels. It was concluded that supplementary nano-Se could improve ADG and reduce the DMI to ADG ratio and fecal heavy metals by altering the bacterial community in feedlot goats. We recommend a dietary supplementation of approximately 0.4 mg nano-Se/kg DM for feedlot Hainan black goats, but further research is warranted to determine the precise dose and the possible contamination risks of Se.
Genetic Diversity and Phylogenetic Analysis of the Endangered Transylvanian Pinzgau Cattle: A Key Resource for Biodiversity Conservation and the Sustainability of Livestock Production
Authors: Davidescu Mădălina-Alexandra , Pânzaru Claudia , Mădescu Bianca-Maria , Radu-Rusu Răzvan-Mihail , Doliș Marius Gheorghe , Simeanu Cristina , Usturoi Alexandru , Ciobanu Andrei , Creangă Șteofil
Published: December 2024

Animal biodiversity is essential for maintaining the functionality of local food systems and ensuring sustainable livelihoods. Starting in 2000, the Food and Agriculture Organization of the United Nations (F.A.O.) has drawn attention to the decline in cattle populations, including the Transylvanian Pinzgau breed from Romania. Renowned for its hardiness, adaptability, and enhanced resistance to diseases and climate change, the Transylvanian Pinzgau is regarded as an important genetic asset for advancing livestock production. As a result, tracking genetic diversity has become a key focus in breeding programs, particularly for small, endangered local populations that play a vital role in regional agro-ecological systems. This research paper sought to assess the genetic diversity of a group of 24 head of cattle from the Transylvania region by analyzing two mtDNA markers, cytochrome b and D-loop sequences, both widely recognized for their relevance and importance in the analysis of genetic diversity of cattle and phylogenetic studies. The findings, derived through statistical analysis of nucleotide sequences using specialized software, indicated that the analyzed cattle are part of the ancestral T haplogroup, with a direct lineage tracing back to Bos taurus. This information can aid in developing crossbreeding programs focused on conserving essential genetic resources, improving other cattle breeds, and protecting biodiversity.
Impact of Organic Fertilizer Substitution and Chemical Nitrogen Fertilizer Reduction on Soil Enzyme Activity and Microbial Communities in an Apple Orchard
Authors: Yan Yuyang , Zhang Xinran , Liu Yuan , Hou Lei , Geng Zengchao , Hu Feinan , Xu Chenyang
Published: December 2024

To mitigate the issues of soil quality degradation and environmental pollution caused by excessive fertilizer use in apple orchards, the present study investigated the effects of organic fertilizer substitution combined with chemical nitrogen (N) fertilizer reduction on soil nutrient status, enzyme activity, and microbial communities (bacteria, fungi and archaea) over one year in an apple orchard. Five fertilization treatments were implemented, including 100% chemical fertilizer (CK), 80% chemical fertilizer + 20% liquid humic fertilizer (S1), 60% chemical fertilizer + 40% liquid humic fertilizer (S2), 60% chemical fertilizer + 20% liquid humic fertilizer (S3), and 40% chemical fertilizer + 40% liquid humic fertilizer (S4). Substituting chemical fertilizers with liquid humic fertilizers effectively enhanced the soil organic matter (SOM) content in the topsoil (0–20 cm) for all treatments. Compared to CK, the amounts of available N (NO3−-N and NH4+-N) were decreased in the topsoil and the amounts of total N, total phosphorous and available phosphorous were increased in the subsoil (20–40 cm) for all treatments. The β-diversity of bacterial communities exhibited the highest sensitivity to soil environmental changes, followed by that of archaea, whereas fungi demonstrated the least susceptibility. The higher soil carbon/nitrogen ratio and SOM content in S2 altered the abundance of microorganisms (Proteobacteria, Ascomycota, and Crenarchaeota) that were closely related to the decomposition and mineralization of SOM and N, enhancing the efficiency of SOM decomposition. The activities of sucrase (SUC), urease (UE), and phosphatase were increased, also promoting the conversion efficiency of SOM and improving N fixation and soil fertility. In the organic fertilizer substitution treatments (S1 and S2), the abundance of dominant Actinobacteriota, Ascomycota and Crenarchaeota phyla were increased, as well as the activities of SUC and UE, accelerating the decomposition and mineralization of SOM and improving soil fertility. In the top, organic fertilizer substitution combined with reduced chemical N fertilizer (S3 and S4) treatments increased the abundance of bacteria and fungi. In addition, RDA showed that total potassium content could significantly affect changes in the bacterial and fungal community structure in subsoil. Overall, organic fertilizer substitution enhanced the content of soil available nutrients and improved soil nutrient retention. It is recommended to promote organic fertilizer substitution + chemical N fertilizer reduction (S4) with the supplementation of potassium fertilizer in the subsoil. The findings provide a theoretical basis and practical guidance for improving orchard soil management and achieving sustainable development in the apple industry.
Rice Shoot 13C Abundance at Maximum Tillering Stage Is Well Suited to Distinguish Differences in Water Use Efficiency for Water-Saving Rice Technologies
Authors: Tao Yueyue , Zhang Yanan , Dittert Klaus , Guo Lin , Liu Meiju , Lin Shan
Published: December 2024

Water availability is one of the most limiting factors in crop production, and understanding crop water use efficiency is especially important in environments where changes in crop performance are driven by water availability. The stable isotope δ13C has been proposed to evaluate the water management and physiological water use efficiency (WUE) for upland crops. However, this technique has rarely been used for rice, especially for water-saving management systems such as the Ground Cover Rice Production System (GCRPS), which can significantly improve WUE. Therefore, a two-year lowland rice field experiment was conducted to evaluate the effects of sampling time, plant organ and yearly climatic changes on δ13C and its relationship to WUE. Our study revealed the following: (1) Significant differences in shoot and leaf δ13C were found between paddy and GCRPS plants only at the maximum tillering stage but not at the flowering stage. (2) The shoot δ13C at maximum tillering showed a significant positive correlation with irrigation (WUEi) and total water use efficiency (WUEt), but there was no such relationship at the flowering stage. (3) Shoot δ13C was significantly higher in 2013 than in 2014, most likely related to higher solar radiation from transplanting to maximum tillering in 2013, as there were no significant differences between the years in other climatic factors and soil water content. Our results suggest that the δ13C of rice shoots sampled at the maximum tillering stage shows the best correlation with crop water use efficiency.
Efficacy of Antimicrobial Dry Fog in Improving the Environmental Microbial Burden in an Inpatient Ward
Authors: Jalali Yashar , Kološová Andrea , Džupa Karol , Pavlovič Pavol , Jalali Monika , Rácek Peter , Zicháčková Nikola , Kyselovič Ján , Vasiková Adriana , Glodová Klaudia , Payer Juraj
Published: December 2024

Background/Objectives: In healthcare environments with high microbial loads, effective infection control measures are critical for reducing airborne and surface contamination. One of the novel modalities in the achievement of these goals is the use of antimicrobial mists, such as droplets, in the form of dry fog. Although the usage of dry fog in the disinfection of contained healthcare microenvironments is well known, the effect of such a system in terms of a meaningful reduction in the microbial burden in an open inpatient ward is unclear. Our objective was to assess the impact of scheduled dry fogging on microbial reduction in such settings. Methods: We collected air and surface samples from rooms receiving daily, biweekly, or no fogging (controls) over six months, establishing the baseline contamination and evaluating the reduction trends in treated rooms. The “reduction effect” was measured by tracking microbial isolation trends before and after treatment, while the “degree of reduction” assessed differences across rooms with varied disinfection schedules. Results: The results indicate that scheduled dry fogging significantly reduced microbial loads in treated rooms, especially with daily disinfection (SE = 64.484, p = 0.002). The airborne contamination in treated rooms showed a strong downward trend over time (SE = 19.192, p < 0.001). Surface contamination remained challenging due to frequent recontamination; however, treated rooms exhibited a consistent reduction in microbial presence (SE = 2.002, p = 0.010), confirming dry fogging’s role as a valuable adjunct to routine cleaning. Conclusions: In conclusion, this study highlights that dry fogging effectively reduces microbial loads in open, high-traffic healthcare environments, supporting its use as part of a multimodal infection control strategy.
Investigation of Temperature-Step Aging of Beef Sirloin on Techno-Functional and Microbiological Attributes
Authors: Wolf Gyöngyi Katalin , Jónás Gábor , Dalmadi István , Csurka Tamás
Published: December 2024

In today’s increasingly demanding market, there is a growing need for high-quality beef products that offer exceptional sensory attributes and provide a premium gastronomic experience. The aim of this research was to develop a beef aging technology that is food-safe (validated by microbiological measurement), produces meat with a desirable color and texture as well as techno-functional properties (drip loss, pH), and also minimizes aging time. The experiments included a temperature-stepped, anaerobic process carried out in vacuum packaging. According to the temperature steps, SAMPLE GROUP I remained at 5 °C throughout the four-week aging period. SAMPLE GROUP II transitioned to a 1 °C environment after the first week, while SAMPLE GROUP III moved from a 5 °C to a 1 °C environment after the second week, and SAMPLE GROUP IV moved after the third week. Instrumentally measured parameters, such as the drip loss, pH, color, texture, and microbiological characteristics of the fresh meat, and at each week of aging for each group, were examined and evaluated by ANOVA or MANOVA. The study found that the drip loss decreased during the first week of aging, then increased, with no strong correlation to temperature. The pH increased in the first week, then decreased, which is linked to microbiological processes, though the changes were not statistically significant. Anaerobic microbial counts rose across all groups but remained within safe limits. Texture analysis showed that meat tenderness peaked after the first week due to proteolytic activity, with Fmax showing significant group differences. Using the technology presented in this paper, optimal aging was achieved after one week, but trend-like results suggested further changes and furthering the aging process will develop a harder texture.
Examining the Effectiveness of Mnemonics Serious Games in Enhancing Memory and Learning: A Scoping Review
Authors: Fung Kingson , Oyibo Kiemute
Published: December 2024

Mnemonics hold potential for promoting long-term memory. Hence, they are being leveraged in serious games aimed to support long-term retention and retrieval of information. However, there is limited work focused on synthesizing the published research and findings on mnemonics serious games with a view to uncovering the extent of their application and effectiveness. This scoping review aims to bridge this gap. Articles were retrieved from four databases (ACM Library, IEEE Xplore, Scopus, and Web of Science). The criteria for inclusion were that the papers must be user studies that focused on mnemonics and serious games at the same time, were written in English, and were published in peer-reviewed journals or conferences. Two researchers, with the guidance of a senior researcher, independently and collaboratively assessed the eligibility of the retrieved papers using the PRISMA flowchart, elicited the relevant data, and tabulated the results in tables and charts using the GPS (game play, purpose, and scope) model. There were 12 papers that were accepted in this scoping review. Overall, most of the mnemonics serious games had a positive effect on memory, suggesting that they hold potential for promoting long-term memory, especially in memorization-intensive instructions, where a good number of students still struggle to retain taught material due to pedagogical, personal, and social challenges. However, more research still needs to be conducted, especially in the area of player-created mnemonics and teaching users how mnemonics can be effectively created using visualization and elaboration techniques.
Hybrid Crow Search Algorithm–LSTM System for Enhanced Stock Price Forecasting
Authors: Jiang Chang-Long , Tsai Yi-Kuang , Shao Zhen-En , Lee Shih-Hsiung , Hsueh Cheng-Che , Huang Ko-Wei
Published: December 2024

This study presents a hybrid crow search algorithm–long short-term memory (CSLSTM) system for forecasting stock prices. This system allows investors to effectively avoid risks and enhance profits by predicting the closing price the following day. This method utilizes a stacking ensemble of long short-term memory (LSTM) networks, with the crow search algorithm (CSA) optimizing the weights assigned to the predictions from multiple LSTM models. To improve the overall accuracy, this system leverages three distinct datasets: technical analysis indicators; price fluctuation limits; and variation mode decomposition (VMD) subsignal sequences. The predictions for the three reference-data types are more comprehensive than single-model or single-data-type approaches. The prediction accuracies of the recurrent neural network, gate recurrent unit, and the LSTM network for five stocks were compared. The proposed CSLSTM system outperforms the other standalone models. Furthermore, we conducted backtesting to demonstrate that the prediction information from our model could generate profit in the stock market, enabling users to benefit from complex stock-market dynamics. The stock prices in this study are expressed in New Taiwan Dollars (TWD), the official currency of Taiwan.
Charging Strategies for Electric Vehicles Using a Machine Learning Load Forecasting Approach for Residential Buildings in Canada
Authors: Mohsenimanesh Ahmad , Entchev Evgueniy
Published: December 2024

The global electric vehicle (EV) market is experiencing exponential growth, driven by technological advancements, environmental awareness, and government incentives. As EV adoption accelerates, it introduces opportunities and challenges for power systems worldwide due to the large battery capacity, uncertain charging behaviors of EV users, and seasonal variations. This could result in significant peak–valley differences in load in featured time slots, particularly during winter periods when EVs’ heating systems use increases. This paper proposes three future charging strategies, namely the Overnight, Workplace/Other Charging Sites, and Overnight Workplace/Other Charging Sites, to reduce overall charging in peak periods. The charging strategies are based on predicted load utilizing a hybrid machine learning (ML) approach to reduce overall charging in peak periods. The hybrid ML method combines similar day selection, complete ensemble empirical mode decomposition with adaptive noise, and deep neural networks. The dataset utilized in this study was gathered from 1000 EVs across nine provinces in Canada between 2017 and 2019, encompassing charging loads for thirty-five vehicle models, and charging locations and levels. The analysis revealed that the aggregated charging power of EV fleets aligns and overlaps with the peak periods of residential buildings energy consumption. The proposed Overnight Workplace/Other Charging Sites strategy can significantly reduce the Peak-to-Average Ratio (PAR) and energy cost during the day by leveraging predictions made three days in advance. It showed that the PAR values were approximately half those on the predicted load profile (50% and 51%), while charging costs were reduced by 54% and 56% in spring and winter, respectively. The proposed strategies can be implemented using incentive programs to motivate EV owners to charge in the workplace and at home during off-peak times.
Application of Thermography and Convolutional Neural Network to Diagnose Mechanical Faults in Induction Motors and Gearbox Wear
Authors: Resendiz-Ochoa Emmanuel , Trejo-Chavez Omar , Saucedo-Dorantes Juan J. , Morales-Hernandez Luis A. , Cruz-Albarran Irving A.
Published: December 2024

Nowadays, induction motors and gearboxes play an important role in the industry due to the fact that they are indispensable tools that allow a large number of machines to operate. In this research, a diagnosis method is proposed for the detection of different faults in an electromechanical system through infrared thermography and a convolutional neural network (CNN). During the experiment, we tested different conditions in the motor and the gearbox. The induction motor was operated in four conditions, in a healthy state, with one broken bar, a damaged bearing, and misalignment, while the gearbox was operated in three conditions with healthy gears, 50% wear, and 75% wear. The motor failures and gear wear were induced by different machining operations. Data augmentation was then performed using basic transformations such as mirror image and brightness variation. Ablation tests were also carried out, and a convolutional neural network with a basic architecture was proposed; the performance indicators show a precision of 98.53%, accuracy of 98.54%, recall of 98.65%, and F1-Score of 98.55%. The system obtained confirms that through the use of infrared thermography and deep learning, it is possible to identify faults at different points of an electromechanical system.
Should We Expect a Second Wave of AlphaFold Misuse After the Nobel Prize?
Authors: de Brevern Alexandre G.
Published: December 2024

AlphaFold (AF) was the first deep learning tool to achieve exceptional fame in the field of biology [...]
Research on the Effect Mechanism of Career-Specific Parental Support Promoting Meaning in Life of Chinese Higher Vocational College Students
Authors: Wang Huadi , Liu Jiawen , Li Chunyu , Fang Anqi , Wang Gongjing
Published: December 2024

Adolescent students’ meaning in life is an important topic of research in positive psychology and educational psychology. Meaning in life is of outstanding value to the whole career development of Chinese higher vocational college students (CHVCS), and parental behaviors have a profound impact on CHVCS’ meaning in life. In order to explore the mechanism of the role of career-specific parental support in promoting CHVCS’ meaning in life from the perspective of career, this study was based on career construction theory (CCT) and investigated 2498 CHVCS. The results showed that (1) career-specific parental support could directly and positively influence meaning in life; (2) core self-evaluations, career exploration, and career adaptability individually played a partially mediating effect in the relationship between career-specific parental support and meaning in life; (3) “core self-evaluations + career exploration”, “core self-evaluations + career adaptability”, “career exploration + career adaptability”, and “core self-evaluations + career exploration + career adaptability” play a partial chain mediating effect in the relationship between career-specific parental support and meaning in life. This study contributes to meaning in life in CHVCS, enriches career-related research based on CCT, and has important implications for career counseling from a construct perspective.
Evaluation of the Thermal Insulation Potential of Post-Harvest Blocks Using the Native Strain of the Edible Mushroom Pleurotus ostreatus
Authors: Aravena Miguel , Almonacid-Muñoz Leonardo , Rojas-Herrera Carlos , Herrera Héctor , Cárdenas-Ramírez Juan Pablo , Veliz Reyes Alejandro , Sagredo-Saez Cristiane
Published: December 2024

In recent years, the need to adopt materials that are partially or fully recyclable or biodegradable has grown significantly. This paper presents a study aiming to develop a physical and thermal characterization of post-harvest blocks (spent mushroom substrate) used in the production of the edible mushroom Pleurotus ostreatus in order to test its feasibility as an insulation material. For this purpose, culture blocks based on wheat straw residues were prepared using a wild strain of the fungus. After the mushroom harvest, the post-harvest blocks were evaluated for stability, thermal conductivity, moisture content, fire behavior, and surface analysis. The results showed that the post-harvest blocks had an average thermal conductivity of 0.032 W/mK, a density of 56.63 kg/m3, and a moisture content of 5.96%. They also exhibited high fire resistance. The culture blocks showed stable dimensional properties, reasonable productivity, low moisture, high density, and fire resistance. Therefore, results suggest that this material could be used as insulation in construction.
Vibration in Floors Induced for Human Walking: Comparison of Two Design Guidelines
Authors: López Cela Juan José , Martínez Vicente Juan Luis
Published: December 2024

The design of floors must fulfill not only the requirements for the Ultimate Limit State but the Serviceability Limit State, which affects, among other factors, the comfort of the users. Due to the modern design of floors and changes in the use of buildings, the effect of human walking and the vibrations induced by this activity can be a determinant factor in the correct design of a floor. National codes are mainly focused on the Ultimate Limit State and give brief recommendations for the Serviceability Limit Sate. In parallel, several design guidelines have been published to assist in the design phase of floors. In this work, we compute the dynamic response of floors excited by human walking using two guidelines, The American Institute of Steel Construction Design Guide (AISC) and the European Guidelines on Human-Induced Vibration of Steel Structures (JRC-ECCS). To compare both design guidelines, we transform the maximum acceleration obtained with the AISC guidelines in velocity and then compare the maximum velocities for different values of natural frequencies, modal masses and damping ratios of the floor under evaluation. The similarities and differences in the response of the floors are studied, as well as the tolerance limits imposed by the guidelines that indicate if the floor design is correct for the comfort of the users.
Characteristics of the Outdoor Environment Affording Physical Activity, Motor Competence, and Social Interactions in Children Aged 3–7 Years: A Systematic Review
Authors: Taylor Nicola , Pringle Andy , Roscoe Clare M. P.
Published: December 2024

Early childhood education (ECE) settings play a crucial role in promoting physical and social development among children aged 3–7 years. This systematic review sought to examine the associations between characteristics of ECE outdoor environments, social interactions, physical activity, and motor competence. The secondary aim examines previously applied methods to capture children’s behaviour in the context of their social and physical environment. Methods: This review used the PRISMA framework and study quality was assessed using the mixed-methods appraisal tool (MMAT). Keyword searches were conducted in seven databases. Studies were eligible if children were aged 3–7 years in ECE; physical activity, social interactions and/or motor competence were measured; location and/or social context were measured. Results were synthesised using an effect direct plot, a table of associations, and narrative synthesis. Results: Twenty-three studies from eight countries met the inclusion criteria. Intervention and controlled cross-sectional studies (n = 9) favoured high-quality outdoor environments rich in affordances, portable play equipment, and natural features to increase children’s physical activity, social interactions, and cooperative play. Cross-sectional and descriptive studies (n = 14) positively associated open grassy space, portable and fixed equipment, wheeled toys, and paths with physical activity (p < 0.05). Based on limited evidence, playground size and active games in small groups were associated with greater MC. Conclusions: The findings highlight the benefit of creating diverse affordance rich outdoor environments in early childhood settings to promote physical and social development. Limitations include variability in study designs and protocols for conducting systematic observations, thus emphasising the need for standardised approaches to future research.
Projected Changes in Dry and Wet Spells over West Africa during Monsoon Season Using Markov Chain Approach
Authors: Basse Jules , Camara Moctar , Diba Ibrahima , Diedhiou Arona
Published: December 2024

This study examines projected changes in dry and wet spell probabilities in West Africa during the July–August–September monsoon season using a Markov chain approach. Four simulations of regional climate models from the CORDEX-Africa program were used to analyze projected changes in intraseasonal variability. The results show an increase in the probability of having a dry day, a dry day preceding a wet day, and a dry day preceding a dry day, and a decrease in the probability of wet days in the Sahel region under anthropogenic forcing scenarios RCP4.5 and RCP8.5. The decrease in wet days is stronger in the far future and under the RCP8.5 scenario (up to −30%). The study also finds that the probability of consecutive dry days (lasting at least 7 days and 10 days) is expected to increase in western Sahel, central Sahel, and the Sudanian Area under both scenarios, with stronger increases in the RCP8.5 scenario. In contrast, a decrease is expected over the Guinea Coast, with the changes being more important under the RCP4.5. Dry spell probabilities increasing in the Sahel areas and in the northern Sudanian Area is linked to the increase in the very wet days (R95P) in the daily rainfall intensity index (SDII). These changes in dry and wet spell probabilities are important for water management decisions and risk reduction in the energy and agricultural sectors. This study also highlights the need for decision-makers to implement mitigation and adaptation policies to minimize the adverse effects of climate change.
Evaluation of the Effects of Age, Sex, and Dexpanthenol-Containing Skin Care on the Facial and Body Skin Microbiome
Authors: Qaizar Zainab , de Salvo Raffaella , Bieri Gregor , Unbereit Katrin , Montgomery Shannon , Peltier Erwan
Published: December 2024

Given the pivotal role played by the microbiome in skin health, it is important to understand how its composition varies with age, sex, and body site and regular use of topical products. Four studies were carried out to determine the effects of long-term (4-week) use of different dexpanthenol-containing topical products on the skin microbiome of a varied population with cosmetically dry skin. The skin microbiome composition was assessed before and after product usage. No significant changes in microbiome richness or diversity were found for the individual test products; however, a meta-analysis of the combined dataset did show changes in microbiome composition as a function of the subject’s sex, age, and body site. The work presented here demonstrates how the use of carefully formulated topical products on skin, when used in a way that is representative of real-life usage conditions, can respect the microbial diversity present on skin across a widely varied study population.
Daily Measurements from Cardiac Implantable Electronic Devices to Assess Health Status
Authors: Roseboom Eva , Daniëls Fenna , Rienstra Michiel , Maass Alexander H.
Published: December 2024

Cardiac implantable electronic devices (CIEDs) such as pacemakers and implantable cardioverter-defibrillators (ICDs) are increasingly used in the aging population. Modern CIEDs perform daily measurements, mainly aimed at discovering early signs of battery depletion or electrode dysfunction. Changes in thresholds, intracardiac signals, and pacing impedances can be caused by exacerbation of existing conditions or novel clinical problems. Pacing percentages and heart rate histograms can be used to optimize pacemaker programming, but can also be a measure of altered cardiac health status. Several measurements, such as thoracic impedance and patient activity, have been added to inform practitioners about worsening heart failure. In addition, remote monitoring of daily CIED measurements may accommodate for the prevention of the deterioration of clinical conditions. In this review, we discuss the evidence base of CIED algorithms and suggest how to use standard daily measurements to monitor the cardiac and extracardiac health status of patients with CIEDs.