bluuebunny/crossref_metadata_2025 huggingface dataset:
The Predictive Role of Inflammatory Biomarkers and Their Correlation with the Biochemical Profile in Patients with Vasculopathy Undergoing Surgery
Authors: Akácsos-Szász Orsolya-Zsuzsa , Pál Sándor , Nyulas Kinga-Ilona , Szilveszter Mónika , Simon-Szabó Zsuzsánna , Dénes Lóránd , Májai Erzsébet , Huțanu Adina , Stoian Adina , Tilinca Mariana Cornelia , Nemes-Nagy Enikő
Published: November 2024

Inflammation is involved in the pathomechanism of vascular diseases. Pro-inflammatory cytokines are important in perioperative monitoring. The aim of the study was the perioperative assessment of biochemical tests and inflammatory markers in patients with vasculopathy, focusing on the identification of subjects prone to complications. The study was performed between 2020 and 2023 at the Clinical County Hospital in Târgu Mureș on enrolled diabetic and non-diabetic patients with vasculopathy and lower limb surgery (amputation or necrectomy). Pre- and postoperative inflammatory markers, biochemical, and hematological tests (n = 62) were performed. Positive correlation was found between preoperative C-reactive protein (CRP) and interleukin-6 (IL-6) levels, and between preoperative triglyceridemia and glycemia/cholesterolemia. Positive correlation was present between pre- and postoperative values of IL-6, tumor necrosis factor-alfa (TNF-α), CRP, and fibrinogen. Preoperative TNF-α values positively correlated with malondialdehyde (MDA) levels, postoperative TNF-α values with transaminase enzymes. Diabetic patients presented higher IL-6 results compared to non-diabetic subjects. We can conclude that dynamic assessment of inflammatory markers is appropriate for monitoring perioperative course. Half of the subjects presented moderately increased preoperative IL-6 levels, and one quarter had critically high values, which might predict prolonged hospitalization. The assessment of oxidative stress, inflammatory markers and biochemical parameters enables the identification of patients prone to complications, so they can benefit from more complex management.
Modulation of the Respiratory Epithelium Physiology by Flavonoids—Insights from 16HBEσcell Model
Authors: Hoser Jakub , Weglinska Gabriela , Samsel Aleksandra , Maliszewska-Olejniczak Kamila , Bednarczyk Piotr , Zajac Miroslaw
Published: November 2024

Extensive evidence indicates that the compromise of airway epithelial barrier function is closely linked to the development of various diseases, posing a significant concern for global mortality and morbidity. Flavonoids, natural bioactive compounds, renowned for their antioxidant and anti-inflammatory properties, have been used for centuries to prevent and treat numerous ailments. Lately, a growing body of evidence suggests that flavonoids can enhance the integrity of the airway epithelial barrier. The objective of this study was to investigate the impact of selected flavonoids representing different subclasses, such as kaempferol (flavonol), luteolin (flavone), and naringenin (flavanone), on transepithelial electrical resistance (TEER), ionic currents, cells migration, and proliferation of a human bronchial epithelial cell line (16HBE14σ). To investigate the effect of selected flavonoids, MTT assay, trypan blue staining, and wound healing were assessed. Additionally, transepithelial resistance and Ussing chamber measurements were applied to investigate the impact of the flavonoids on the electrical properties of the epithelial barrier. This study showed that kaempferol, luteolin, and naringenin at micromolar concentrations were not cytotoxic to 16HBE14σ cells. Indeed, in MTT tests, a statistically significant change in cell metabolic activity for luteolin and naringenin was observed. However, our experiments showed that naringenin did not affect the proliferation of 16HBE14σ cells, while the effect of kaempferol and luteolin was inhibitory. Moreover, transepithelial electrical resistance measurements have shown that all of the flavonoids used in this study improved the epithelial integrity with the slightest effect of kaempferol and the significant impact of naringenin and luteolin. Finally, our observations suggest that luteolin increases the Cl- transport through cystic fibrosis transmembrane conductance regulator (CFTR) channel. Our findings reveal that flavonoids representing different subclasses exert distinct effects in the employed cellular model despite their similar chemical structures. In summary, our study sheds new light on the diverse effects of selected flavonoids on airway epithelial barrier function, underscoring the importance of further exploration into their potential therapeutic applications in respiratory health.
Antioxidant Activity of Anthocyanins and Anthocyanidins: A Critical Review
Authors: Sadowska-Bartosz Izabela , Bartosz Grzegorz
Published: November 2024

Anthocyanins are the main plant pigments responsible for the color of flowers, fruits, and vegetative organs of many plants, and are applied also as safe food colorants. They are efficient antioxidants. In this review, the reactivity of anthocyanins and their aglycones, anthocyanidins, in the main antioxidant assays, and their reactions with reactive oxygen and nitrogen species, effects of interactions with other compounds and metal ions on the antioxidant activity of anthocyanins and the electrochemical properties of anthocyanins are presented. Numerous cases of attenuation of oxidative stress at the cellular and organismal levels by anthocyanins are cited. The direct and indirect antioxidant action of anthocyanins, the question of the specificity of anthocyanin action in complex extracts, as well as limitations of cellular in vitro assays and biomarkers used for the detection of antioxidant effects of anthocyanins, are critically discussed.
Vascular Extracellular Matrix in Atherosclerosis
Authors: Di Nubila Alessia , Dilella Giovanna , Simone Rosa , Barbieri Silvia S.
Published: November 2024

The extracellular matrix (ECM) plays a central role in the structural integrity and functionality of the cardiovascular system. Moreover, the ECM is involved in atherosclerotic plaque formation and stability. In fact, ECM remodeling affects plaque stability, cellular migration, and inflammatory responses. Collagens, fibronectin, laminin, elastin, and proteoglycans are crucial proteins during atherosclerosis development. This dynamic remodeling is driven by proteolytic enzymes such as matrix metalloproteinases (MMPs), cathepsins, and serine proteases. Exploring and investigating ECM dynamics is an important step to designing innovative therapeutic strategies targeting ECM remodeling mechanisms, thus offering significant advantages in the management of cardiovascular diseases. This review illustrates the structure and role of vascular ECM, presenting a new perspective on ECM remodeling and its potential as a therapeutic target in atherosclerosis treatments.
Ultrasound-Assisted Community Bureau of Reference (BCR) Procedure for Heavy Metal Removal in Sewage Sludge
Authors: Marin Nicoleta Mirela , Galaon Toma , Pascu Luoana Florentina
Published: November 2024

Sewage sludge (SS) resulting from wastewater treatment plants (WWTP) is commonly applied worldwide as a fertilizer in agriculture. This can be done following a rigorous analysis of the sewage sludge composition. Due to its toxic potential, heavy metal ion content is one of the key parameters to test when evaluating SS sample usage as fertilizer. The distribution of metals present in SS samples produced by five municipal WWTPs in Romania was studied. To obtain information regarding metal distribution in SS, a modified ultrasound-assisted extraction procedure of the Community Bureau of Reference (BCR) was employed for As, Cd, Cr, Cu, Mo, Ni, Pb, Zn, and Co quantitation. Concentrations of these metals were measured using ICP-EOS spectrometry. Method extraction accuracy was verified using CRM-483 certified reference material. Results show that extraction efficiency was lowest for the exchangeable fraction for all studied metals. The detected ion metals were found distributed in fractions (F) 2, 3 and 4, which are unavailable for plants and groundwater under natural environmental conditions. One noteworthy finding was that using ultrapure water for the leachate test resulted in low metal solubility, indicating slight metal desorption in real environmental samples. Furthermore, maize stalk bio-adsorbent was used to minimize metal ion content in WWTP leachate samples produced by the storage of SS in terms of metal ion adsorption.
Impact of Pluronic F-127 on the Stability of Quercetin-Loaded Liposomes: Insights from DSC Preformulation Studies
Authors: Kosti Effrosyni-Maria , Sotiropoulou Heliana , Tsichlis Ioannis , Tsakiri Maria , Naziris Nikolaos , Demetzos Costas
Published: November 2024

The aim of the present study is to evaluate the stability of DMPC:Pluronic F-127 and DPPC:Pluronic F-127 liposomes, both with and without incorporated quercetin. Quercetin belongs to the class of flavonoids and has shown antioxidant, antiviral, anti-inflammatory, anti-cancer, and antimicrobial activities. Dynamic light scattering, electrophoretic light scattering, and differential scanning calorimetry (DSC) were utilized to investigate the cooperative behavior between liposomal components and its effect on stability. All formulations were stored at 4 °C and 25 °C and studied over 42 days. Furthermore, the interaction of the final formulations with serum proteins was assessed to evaluate the potential of Pluronic F-127 as a stabilizer in these liposomal nanosystems. This study highlights the impact of DSC in preformulation evaluations by correlating thermal behavior with quercetin incorporation and variations in size and the polydispersity index. According to the results, quercetin increased the fluidity and stability of liposomal nanosystems, while Pluronic F-127 was not sufficient for effective steric stabilization. Additionally, DSC thermograms revealed the integration of Pluronic F-127 into lipid membranes and showed phase separation in the DMPC nanosystem. In conclusion, the results indicate that the DPPC:Pluronic F-127:quercetin nanosystem exhibited the desired physicochemical and thermotropic properties for the effective delivery of quercetin for pharmaceutical purposes.
Automatic Defects Recognition of Lap Joint of Unequal Thickness Based on X-Ray Image Processing
Authors: Chi Dazhao , Wang Ziming , Liu Haichun
Published: November 2024

It is difficult to automatically recognize defects using digital image processing methods in X-ray radiographs of lap joints made from plates of unequal thickness. The continuous change in the wall thickness of the lap joint workpiece causes very different gray levels in an X-ray background image. Furthermore, due to the shape and fixturing of the workpiece, the distribution of the weld seam in the radiograph is not vertical which results in an angle between the weld seam and the vertical direction. This makes automatic defect detection and localization difficult. In this paper, a method of X-ray image correction based on invariant moments is presented to solve the problem. In addition, a novel background removal method based on image processing is introduced to reduce the difficulty of defect recognition caused by variations in grayscale. At the same time, an automatic defect detection method combining image noise suppression, image segmentation, and mathematical morphology is adopted. The results show that the proposed method can effectively recognize the gas pores in an automatic welded lap joint of unequal thickness, making it suitable for automatic detection.
Correction: Wu et al. Synthesis of Spirooxindole-O-Naphthoquinone-Tetrazolo[1,5-a]Pyrimidine Hybrids as Potential Anticancer Agents. Molecules 2018, 23, 2330
Authors: Wu Liqiang , Liu Yunxia , Li Yazhen
Published: November 2024

In the original publication [...]
Exploring Bioinformatics Solutions for Improved Leishmaniasis Diagnostic Tools: A Review
Authors: Capistrano Costa Natáli T. , de Souza Pereira Allana M. , Silva Cibele C. , Souza Emanuelle de Oliveira , de Oliveira Beatriz C. , Ferreira Luiz Felipe G. R. , Hernandes Marcelo Z. , Pereira Valéria R. A.
Published: November 2024

Significant populations in tropical and sub-tropical locations all over the world are severely impacted by a group of neglected tropical diseases called leishmaniases. This disease is caused by roughly 20 species of the protozoan parasite from the Leishmania genus. Disease prevention strategies that include early detection, vector control, treatment of affected individuals, and vaccination are all essential. The diagnosis is critical for selecting methods of therapy, preventing transmission of the disease, and minimizing symptoms so that the affected individual can have a better quality of life. Nevertheless, the diagnostic methods do eventually have limitations, and there is no established gold standard. Some disadvantages include the existence of cross-reactions with other species, and limited sensitivity and specificity, which are mostly determined by the type of antigen used to perform the tests. A viable alternative for a more precise diagnosis is the application of recombinant antigens, which have been generated using bioinformatics approaches and have shown increased diagnostic accuracy. This approach proves valuable as it spans from epitope selection to predicting the interactions within the antibody–antigen complex through docking analysis. As a result, identifying potential new antigens using bioinformatics resources becomes an effective technique since it may result in an earlier and more accurate diagnosis. Consequently, the primary aim of this review is to conduct a comprehensive overview of the most significant in silico tools developed over time, with a focus on evaluating their efficacy and exploring their potential applications in optimizing the selection of highly specific molecules for a more effective diagnosis of leishmaniasis.
Optimization of the Production of Secondary Metabolites from Furanocoumarin and Furoquinoline Alkaloid Groups in In Vitro Ruta corsica Cultures Grown in Temporary Immersion Bioreactors
Authors: Szewczyk Agnieszka , Trepa Monika , Zych Dominika
Published: November 2024

Ruta corsica is a rare and endemic plant native to Corsica. Due to its limited distribution and the priority to preserve natural sites, has been insufficiently studied. In vitro cultures provide an opportunity to research R. corsica under controlled conditions. In the present study, in vitro cultures of R. corsica were conducted in PlantformTM bioreactors. The study aimed to assess the effects of growth cycle length (5 and 6 weeks) and different concentrations of plant growth regulators (NAA and BAP) at 0.1/0.1, 0.1/0.5, 0.5/0.5, 0.5/1.0, and 1.0/1.0 mg/L on biomass growth and secondary metabolite accumulation. HPLC analysis identified compounds in the furanocoumarin and furoquinoline alkaloid groups, with furanocoumarins being the primary secondary metabolites (maximum total content: 1571.5 mg/100 g DW). Among them, xanthotoxin, psoralen, and bergapten were dominant, with maximum concentrations of 588.1, 426.6, and 325.2 mg/100 g DW, respectively. The maximum total content of furoquinoline alkaloids was 661 mg/100 g DW, with γ-fagarine as the primary metabolite, reaching 448 mg/100 g DW. The optimal conditions for secondary metabolite accumulation in R. corsica cultures were a 5-week growth cycle and the LS 0.1/0.1 medium variant.
Effect of Ag+ and Cd2+ Elicitation on Polyphenol Production in Shoot Culture of Dracocephalum ruyschiana L.
Authors: Weremczuk-Jeżyna Izabela , Gomulski Jan , Kiss Anna K. , Grzegorczyk-Karolak Izabela
Published: November 2024

Abiotic elicitation with heavy metals has demonstrated considerable potential to stimulate the production of industrially important secondary metabolites in plant in vitro cultures. The present study investigates the effect of exogenous silver nitrate and cadmium chloride supplementation on flavonoid and phenolic acid production, as well as other indicators of oxidative stress, in shoot cultures of Dracocephalum ruyschiana L. Owing to the presence of bioactive polyphenolic compounds, this Mongolian medicinal plant is traditionally used as an anti-inflammatory, antibacterial and antipyretic agent. The shoots were cultured for three weeks, and then, cadmium (Cd2+) and silver (Ag+) ions (50 or 100 µM) were added to the medium. The maximum proliferation rate was observed in the presence of 100 µM Ag+ (almost 5), the highest chlorophyll content in the presence of 100 µM Cd2+ (0.6 mg/g FW) and the highest biomass was observed with both these treatments (73.4–75.7 g FW and 7.53–7.72 g DW). UPLC-PDA-ESI-MS analysis revealed four phenolic acids and five flavonoid derivatives in the hydromethanolic extract of D. ruyschiana shoots. All treatments stimulated the production of rosmarinic acid (RA), which was the dominant compound in the analyzed culture; the highest level of RA, i.e., about three times higher than the control, was noted in shoots exposed to 50 µM Cd2+ (14.72 mg/g DW), whereas the level of most flavonoids in the culture increased most significantly when exposed to Cd2+ at a concentration of 100 µM. Moreover, the shoots grown in the presence of 100 µM Cd2+ exhibited significantly higher antioxidant potential in comparison to the control. Our findings indicate that heavy metals are able to stimulate phenolic compound biosynthesis in Dracocephalum shoots without any negative impact on their growth. These results could be of significant importance for the medical, nutraceutical and agronomic industries.
Optimisation of the Ethanol Fermentation Process Using Hydrothermal Pretreatment of Cellulose Waste—Effect of Fermentation Pattern and Strain
Authors: Zhou Jun , Lv Pin , He Binsheng , Wu Jingjing , Wang Gao , Ma Hongzhi , Wang Yueyao , Chen Guiyun
Published: November 2024

Suitable fermentation substrates and fermentation modes can effectively improve the fermentation ethanol yield. In this study, we optimised the hydrothermal pretreatment conditions by orthogonal optimisation using waste tissue paper as substrate. These conditions consisted of 50 min duration in a high-pressure reactor with pure water as solvent at a temperature of 160 °C. The biomass to water ratio was maintained at a constant level. The cellulose content of the pretreated TP was 81.19 ± 4.06%, which was an increase of 21.59% compared to the blank control. The 72 h reducing sugar yield of pretreated TP was 0.61 g sugar/g paper, which was 38.64% higher than that of untreated TP. Subsequently, the pretreated TP was fermented under optimal conditions. The mixed group of Saccharomyces cerevisiae and Candida shehatae (SC) showed a distributed saccharification fermentation pattern, with an ethanol yield of 28.11 g/L in 72 h. On the other hand, the single Saccharomyces cerevisiae (S) exhibited a homobloc saccharification fermentation pattern, with an ethanol yield of 35.15 g/L in 72 h.
Regioselective Synthesis of Potential Non-Quinonoid Prodrugs of Plasmodione: Antiparasitic Properties Against Two Hemoglobin-Feeding Parasites and Drug Metabolism Studies
Authors: Cesar-Rodo Elena , Dupouy Baptiste , Häberli Cécile , Strub Jean-Marc , Williams David L. , Mäser Pascal , Rottmann Matthias , Keiser Jennifer , Lanfranchi Don Antoine , Davioud-Charvet Elisabeth
Published: November 2024

Ψ-1,4-naphthoquinones (Ψ-NQ) are non-quinoid compounds in which aromaticity—found in 1,4-naphthoquinones—is broken by the introduction of an angular methyl at C-4a or -8a. This series was designed to act as prodrugs of 1,4-naphthoquinones in an oxidative environment. Furthermore, from a medicinal chemistry point of view, the loss of planarity of the scaffold might lead to an improved solubility and circumvent the bad reputation of quinones in the pharmaceutical industry. In this work, we illustrated the concept by the synthesis of Ψ -plasmodione regioisomers as prodrugs of the antimalarial plasmodione. The presence of a chiral center introduces a new degree of freedom to be controlled by enantioselectivity and regioselectivity of the cycloaddition in the Diels–Alder reaction. The first strategy that was followed was based on the use of a chiral enantiopure sulfoxide to govern the stereoselective formation of (+)Ψ-NQ or (−)Ψ-NQ, depending on the chirality of the sulfoxide (R or S). New sulfinylquinones were synthesized but were found to be ineffective in undergoing cycloaddition with different dienes under a wide range of conditions (thermal, Lewis acid). The second strategy was based on the use of boronic acid-substituted benzoquinones as auxiliaries to control the regioselectivity. Using this methodology to prepare the (±)Ψ-NQ racemates, promising results (very fast cycloaddition time: ~2 h) were obtained with boronic acid-based quinones 25 and 27 in the presence of 1-methoxy-1,3-butadiene, to generate the 4a- and the 8a-Ψ-plasmodione regioisomers 1 and 2 (synthesized in six steps with a total yield of 10.5% and 4.1%, respectively. As the expected prodrug effect can only be revealed if the molecule undergoes an oxidation of the angular methyl, e.g., in blood-feeding parasites that digest hemoglobin from the host, the antimalarial and the antischistosomal properties of both (±)Ψ-NQ regioisomers were determined in drug assays with Plasmodium falciparum and Schistosoma mansoni. Metabolic studies under quasi-physiological conditions and LC-MS analyses were undertaken to reveal the generation of plasmodione from both the 4a- and the 8a-Ψ-plasmodione regioisomers.
Direct Synthesis of Benzhydryl-Functionalized 3,4-Dihydropyridin-2-ones from 2-Pyridones and Their Use in the Formation of Bridged δ-Lactams
Authors: Myk Zofia M. , Sośnicki Jacek G. , Struk Łukasz
Published: November 2024

A method for the synthesis of C4-benzhydryl-functionalized 3,4-dihydropyridin-2-ones using complementary addition of benzhydryllithium and/or benzhydrylmagnesiate reagents to 2-pyridones, with high regioselectivity triggered by substituents, is described. A partially stereoselective cyclization was successfully demonstrated using TfOH and/or TIPSOTf as Brønsted and Lewis acids, respectively, leading to C6-phenyl-functionalized 7,8-benzomorphanones. It is also shown that the use of functionalized δ-enelactams obtained with an active methoxy-substituted benzyl group at C3 enabled the preparation of a new C3–C6 bridged system within the δ-lactam framework.
Atomistic Modeling of Natural Gas Desulfurization Process Using Task-Specific Deep Eutectic Solvents Supported by Graphene Oxide
Authors: Ismagambetov Olzhas , Aldiyarov Nakhypbek , Almas Nurlan , Irgibaeva Irina , Baitassova Zhadyra , Piskunov Sergei , Aldongarov Anuar , Abdirashev Omirzak
Published: November 2024

This study employs Density Functional Theory (DFT) calculations and traditional all-atom Molecular Dynamics (MD) simulations to reveal atomistic insights into a task-specific Deep Eutectic Solvent (DES) supported by graphene oxide with the aim of mimicking its application in the natural gas desulfurization process. The DES, composed of N,N,N′,N′-tetramthyl-1,6-hexane diamine acetate (TMHDAAc) and methyldiethanolamine (MDEA) supported by graphene oxide, demonstrates improved efficiency in removing hydrogen sulfide from methane. Optimized structure and HOMO-LUMO orbital analyses reveal the distinct spatial arrangements and interactions between hydrogen sulfide, methane, and DES components, highlighting the efficacy of the DES in facilitating the separation of hydrogen sulfide from methane through DFT calculations. The radial distribution function (RDF) and interaction energies, as determined by traditional all-atom MD simulations, provide insights into the specificity and strength of the interactions between the DES components supported by graphene oxide and hydrogen sulfide. Importantly, the stability of the DES structure supported by graphene oxide is maintained after mixing with the fuel, ensuring its robustness and suitability for prolonged desulfurization processes, as evidenced by traditional all-atom MD simulation results. These findings offer crucial insights into the molecular-level mechanisms underlying the desulfurization of natural gas, guiding the design and optimization of task-specific DESs supported by graphene oxide for sustainable and efficient natural gas purification.
Structure Characterization of Four New Sesquiterpene Pyridine Alkaloids from Tripterygium wilfordii Hook. f. and Anti-Inflammatory Activity Evaluations
Authors: Wang Yong-Jian , Yan Jian-Gong , Zhang Zhong-Mou , Fang Qiu-Fang , Wang Ya-Dan , Ma Shuang-Cheng
Published: November 2024

Sesquiterpene pyridine alkaloids (SPAs), as a main class of components in Tripterygium wilfordii Hook. f., possess a variety of bioactivities, such as immunosuppressive, insecticidal, and anti-tumor activities. SPAs can be structurally classed into four subtypes: wilfordate-, evoninate-, iso-wilfordate-, and iso-evoninate types. Our previous study unveiled ten new wilfordate-type SPAs, named wilfordatine A–J, isolated from the roots of Tripterygium wilfordii Hook. f., several of which exhibited significant immunosuppressive activities. As an extension and augmentation of the previous findings, we have now isolated one new iso-wilfordate-type SPA, wilfordatine K (1), alongside three new iso-evoninate-type SPAs, wilfordatines L–N (3–5), and six known analogs. Their structures were characterized by the extensive use of 1D and 2D NMR spectroscopic analysis, as well as HRMS data. Interestingly, compounds 4 and 6 were found to exhibit potent inhibitory effects on the nuclear factor-kappa B (NF-κB) pathway in lipopolysaccharide (LPS)-induced HEK293/NF-κB-Luc cells, with IC50 values of 1.64 μM and 9.05 μM, respectively. Notably, these two compounds had no influence on the cell viability at a concentration of 100 μM. Consequently, they hold significant promise as potential anti-inflammatory candidates for further exploration and development.
A Refined and Efficient CNN Algorithm for Remote Sensing Object Detection
Authors: Liu Bingqi , Mo Peijun , Wang Shengzhe , Cui Yuyong , Wu Zhongjian
Published: November 2024

Remote sensing object detection (RSOD) plays a crucial role in resource utilization, geological disaster risk assessment and urban planning. Deep learning-based object-detection algorithms have proven effective in remote sensing image studies. However, accurate detection of objects with small size, dense distribution and complex object arrangement remains a significant challenge in the remote sensing field. To address this, a refined and efficient object-detection algorithm (RE-YOLO) has been proposed in this paper for remote sensing images. Initially, a refined and efficient module (REM) was designed to balance computational complexity and feature-extraction capabilities, which serves as a key component of the RE_CSP block. RE_CSP block efficiently extracts multi-scale information, overcoming challenges posed by complex backgrounds. Moreover, the spatial extracted attention module (SEAM) has been proposed in the bottleneck of backbone to promote representative feature learning and enhance the semantic information capture. In addition, a three-branch path aggregation network (TBPAN) has been constructed as the neck network, which facilitates comprehensive fusion of shallow positional information and deep semantic information across different channels, enabling the network with a robust ability to capture contextual information. Extensive experiments conducted on two large-scale remote sensing datasets, DOTA-v1.0 and SCERL, demonstrate that the proposed RE-YOLO outperforms state-of-the-art other object-detection approaches and exhibits a significant improvement in generalization ability.
Distributed Passive Positioning and Sorting Method for Multi-Network Frequency-Hopping Time Division Multiple Access Signals
Authors: Mao Jiaqi , Luo Feng , Hu Xiaoquan
Published: November 2024

When there are time division multiple access (TDMA) signals with large bandwidth, waveform aliasing, and fast frequency-hopping in space, current methods have difficulty achieving the accurate localization of radiation sources and signal-sorting from multiple network stations. To solve the above problems, a distributed passive positioning and network stations sorting method for broadband frequency-hopping signals based on two-level parameter estimation and joint clustering is proposed in this paper. Firstly, a two-stage filtering structure is designed to achieve control filtering for each frequency point. After narrowing down the parameter estimation range through adaptive threshold detection, the time difference of arrival (TDOA) and the velocity difference of arrival (VDOA) can be obtained via coherent accumulating based on the cross ambiguity function (CAF). Then, a multi-station positioning method based on the TDOA/VDOA is used to estimate the position of the target. Finally, the distributed joint eigenvectors of the multi-stations are constructed, and the signals belonging to different network stations are effectively classified using the improved K-means method. Numerical simulations indicate that the proposed method has a better positioning and sorting effect in low signal-to-noise (SNR) and low snapshot conditions compared with current methods.
Kasdienos dalyviai ir valstybės ateities kūrėjai: vaiko vaizdinys Pranciškaus Smuglevičiaus kūryboje
Authors: Vitkutė Joana
Published: November 2024

The history of art in Vilnius at the turn of the eighteenth-nineteenth century is unimaginable without the person of Franciszek Smuglewicz (1745–1807). His creative and educational activities attracted a great deal of attention, but one aspect of his artistic work – the depiction of the child in his secular paintings – has not been really discussed. The main aim of this article is to identify and define more precisely the directions and nature of the depiction of secular childhood that emerges in Smuglewicz’s work. The works, relevant to this study, are divided into four thematic categories – mythological, historical, reflecting the artist’s period of life, and images of the characters of the little ones, relevant to the theme of citizenship.
Progressive Personal Income Tax Rate: innovations 2025
Authors:   Department of Economics and Management of the Institute of Economics, Management and Law Moscow City University, Shinkareva O.V.
Published: November 2024

The study considers changes made to the Tax Code of the Russian Federation, which significantly change the tax rates on personal income tax. The study examined the specifics of applying progressive tax rates to the income of employees and individuals attracted by medical organizations under civil law contracts — residents of personal income tax. An analysis of innovations in 2025 in this area was carried out — it was noted that there was a significant expansion of the range of tax rates, which led to an increase in the tax burden of highly paid categories of employees. it is emphasized that the maximum tax rate (22%) will not lead to a significant decrease in motivation for the continuation of the activities of individuals with high incomes. Examples of personal income tax calculation are given when applying the taxation scales in force in 2024 and coming into force in 2025.
Optimization of compensation mechanisms in labor relations
Authors:   Federal State Budgetary Educational Institution of Higher Education “Russian Economic University named after G. Plekhanov”, Ministry of Science and Higher Education of the Russian Federation, Moscow, Russia, Lebedev V.A. , Lebedeva E.I. ,   Non-profit Partnership “Institute of Professional Accountants and Auditors of Russia”, Moscow, Russia
Published: November 2024

The tools for optimizing labor legislation are constantly being supplemented and radically updated, which requires considering the practice of its application. The projected changes in the compensation mechanism for work under irregular working hours are considered, including those related to the legislative limitation of its duration, the obligation of the employer to keep records of the time worked by the employee outside the established working day (shift), establishing the dependence of the duration of additional annual paid leave provided to the employee on the time worked outside the working day. A comparative analysis of the development of the institution of irregular working hours and the specific of its refinement is carried out.
O potencial efeito da musicoterapia em pacientes pediátricos ambulatoriais: um estudo clínico transversal
Authors: Lobão Luiz Henrique Lepesqueur Botelho , Camara Pedro Henrique Zorzetti , Marques Gabriel Pereira , Virgens Karoline Spósito das , Barbosa Fernanda Viel , Santos Guilherme de Castro e , Santos Henrique de Castro e , Teixeira Leonardo Palheta Carvalho , Avancini Renata Vasques Palheta , Mundim Renato Resende
Published: November 2024

Este estudo clínico transversal teve como objetivo investigar o efeito da musicoterapia no bem-estar de pacientes pediátricos atendidos no ambulatório do Centro Universitário do Planalto Central Apparecido dos Santos (UNICEPLAC). Participaram 29 crianças entre 4 e 14 anos, que foram submetidas a sessões de musicoterapia recreativa e interativa. A coleta de dados foi realizada por meio de formulários aplicados antes e após as sessões, avaliando o impacto da intervenção na experiência médica e no bem-estar emocional. Os resultados mostraram que 65,5% das crianças relataram melhora significativa após a musicoterapia, 86,2% demonstraram interesse em participar de futuras sessões e 79,3% afirmaram sentir-se mais confiantes para ir ao médico após a intervenção. A percepção dos responsáveis foi igualmente positiva, com 66,7% relatando que a musicoterapia ajudou consideravelmente seus dependentes. Esses achados sugerem que a musicoterapia pode ser uma ferramenta eficaz e complementar no atendimento pediátrico, promovendo uma abordagem mais humanizada e lúdica no ambiente ambulatorial.
Perfil de prescrição de medicamentos para pacientes em Cuidados Paliativos em um Hospital Universitário do Paraná
Authors: Mierlo Milena Godoi Van , Veber Ana Paula , Barbosa Fernanda Malaquias , Batista Thais
Published: November 2024

O presente estudo justifica-se pela importância dos Cuidados Paliativos (CP) na melhoria da qualidade de vida de pacientes com doenças crônicas ou que ameaçam a vida, e pela necessidade de entender o perfil das prescrições realizadas para esses pacientes. Objetiva-se analisar as prescrições de pacientes internados em Cuidados Paliativos em um hospital universitário no interior do estado do Paraná, e identificar os medicamentos mais frequentemente prescritos no momento da alta. Para tanto, realizou-se um estudo transversal, retrospectivo e descritivo, baseado na análise de 150 prescrições de 147 pacientes, coletadas de prontuários eletrônicos entre julho de 2023 e abril de 2024. Observou-se que a maioria dos pacientes estava internada na clínica médica, e que os medicamentos mais prescritos foram os destinados ao trato digestivo e metabolismo (30%), seguidos de fármacos para o sistema nervoso (28,5%) e cardiovascular (11,9%). Os principais sintomas tratados foram náuseas, constipação e dor. Conclui-se que os CP têm papel fundamental na gestão dos sintomas, promovendo conforto e melhor qualidade de vida, especialmente através de uma prescrição farmacológica adequada.
A importância do cirurgião-dentista no âmbito esportivo
Authors: Fortes Júlia Rodrigues de Lima , Calixto Jeovana Carla Ricardo , Barbosa Cayo Lucas Correia de Oliveira , Gomes Ittalo Henrique Santos , Pontes Danilo Barros , Barros José Victor Curvelo , Lima Anniely Hellen Cedro , Macêdo Lucas Fortes Cavalcanti de
Published: November 2024

Introdução: A odontologia do esporte é uma especialidade que vem atualmente promovendo a interação entre os cuidados de saúde geral com a saúde bucal dos atletas, sendo responsável primordialmente pela atuação em prevenção, diagnóstico e tratamentos das doenças orais em atletas, constituindo-se como uma nova forma de atuação profissional para o cirurgião dentista (Carvalho, 2020). A odontologia esportiva, durante muitos anos ficou sem a devida atenção e geralmente era relegada ao terceiro plano de atenção a saúde dos atletas. Mas hoje a odontologia esportiva vem crescendo de forma tão visível e se mostrando em uma expansão tão grandiosa em comparação a outras especialidades odontológicas (SOUZA, 2014). Metodologia: O trabalho refere-se de uma pesquisa de revisão integrativa de literatura, para identificar a importância dó cirurgião-dentista no âmbito esportivo, a partir de coleta de dados realizados a partir de fontes secundárias, por meio de levantamento   bibliográfico, tendo   características, descritivas, retrospectiva, com abordagem qualitativa. Conclusão: A odontologia do esporte tem se consolidado como uma especialidade essencial para a manutenção da saúde bucal e o aprimoramento do desempenho dos atletas. Este artigo demonstrou que a saúde oral não apenas afeta a função mastigatória, mas também tem um impacto significativo na performance atlética.
Avaliação do uso de nanotecnologia na quimioterapia neoadjuvante para o câncer de mama: uma revisão de evidências e classificação GRADE
Authors: Manso Vitória Abdala , Oliveira Matheus Lôres de , Pedrosa Eduardo Mujica , Souza Arthur Vinicios Araujo de , Peres Marcela Chaves , Sarres Fabrício Gomes , Brito Pedro Paulo Reis de , Leite Ana Luiza Costa , Botelho André Luís Almeida , Souza Daniel Sebastião de , Rocha Adylla Beatriz de Santana , Melo Ellen dos Santos Alves de , Silva Cristiane Mota da , Guerra Isabela Chaves Chiaretto , Lima Lorrany Nunes de , Souza Lucas Landim De , Costa Sabriny Bianca da , Chaves Marcelo Paraiso
Published: November 2024

O câncer de mama (CM) é o tipo de câncer mais diagnosticado em mulheres, com cerca de 2,3 milhões de novos casos em 2020. Devido à sua heterogeneidade, as estratégias terapêuticas variam amplamente. A quimioterapia neoadjuvante, aplicada antes da cirurgia, tem ganhado destaque, especialmente com a incorporação da nanotecnologia, que promete melhorar a eficácia do tratamento e reduzir efeitos colaterais. Este estudo revisa a literatura sobre a aplicação da nanotecnologia na quimioterapia neoadjuvante para câncer de mama, utilizando a classificação GRADE para avaliar a qualidade das evidências. A pesquisa foi realizada em bases de dados como PubMed e Scopus, e selecionou 8 artigos que analisaram a eficácia de nanopartículas em tratamentos. Os resultados indicam que a nanotecnologia pode potencialmente melhorar as taxas de resposta patológica completa, especialmente em casos de câncer HER2 positivo. Esta revisão enfatiza a importância de abordagens integradas que combinem nanotecnologia, monitoramento biomolecular e quimioterapia para transformar o manejo do câncer de mama, proporcionando tratamentos mais eficazes e personalizados.
Perfil epidemiológico dos casos de meningite em idosos no Brasil no período de 2018 a 2023
Authors: Santos José Victor Dantas dos , Souza Laura Oliveira Silva e , Pavan Beatriz , Tavares Dominique Vieira , Hueb Lara Rocha , Oliveira Arthur Gomes Afonso , Santos Jeane Sousa , Meneses Ana Paula Rodrigues Araújo de Sousa , Inushi Mayra Emi Guinoza , Brito Inês Beatriz Caldas Sendas do Nascimento , Pivatto Felipe Ian Mota , Kimura Yuri Yukio de Sá , Martins Gustavo Henrique Almeida , Rodrigues Ana Carolina Loureiro , Bastos Igor Castro de Oliveira , Feitosa Francisco Jackson Andrade , Vieira Ana Izabele Fernandes , Xavier Arthur Bezerra de Souza , Oliveira Franciclea Mireli dos Santos , Pivatto Alanna Rosa Mota Carvalho
Published: November 2024

A meningite é uma inflamação das meninges, estruturas que envolvem o sistema nervoso central, sendo os idosos um dos grupos etários mais afetados. O conhecimento do perfil epidemiológico da doença é crucial para a prevenção. Este estudo tem como objetivo descrever o perfil epidemiológico dos casos notificados de meningite entre idosos no Brasil, no período de 2018 a 2023. Trata-se de um estudo ecológico baseado em dados do Sistema de Informações de Agravos de Notificação (SINAN), obtidos pelo Departamento de Informática do Sistema Único de Saúde (DATASUS). Foram analisados dados sociodemográficos como macrorregiões, faixa etária e sexo dos indivíduos acometidos. A amostra incluiu 6.402 idosos com idades entre 60 e 80+ anos. O maior número de casos foi registrado em 2018 (n=1.494) e 2019 (n=1.404), totalizando 45,2% dos casos. Observou-se uma redução nos anos de 2020 (n=813) e 2021 (n=873), seguida de um aumento em 2022 (n=1.397). A faixa etária mais afetada foi a de 60-69 anos, com 3.667 notificações (57,2%), sendo 53,1% dos casos do sexo masculino. A região Sudeste apresentou o maior número de casos (n=3.629). O perfil epidemiológico apontou uma prevalência de homens com idade entre 60 e 69 anos, residentes da região Sudeste. Os achados sugerem que os anos de 2020 e 2021 apresentaram subnotificação, possivelmente devido à pandemia de COVID-19. Assim, o aumento de casos de meningite em idosos reforça a necessidade de medidas preventivas específicas para este grupo.
Ectopia testicular transversa: revisão da literatura
Authors: Wanderley Alana Emilly Andrade de Souza , Loureiro Norma Caroline Furtado Montenegro , Souza Ana Paula Maia de
Published: November 2024

O objetivo deste estudo é realizar uma revisão integrativa da literatura para compreender os achados de imagem nos diferentes métodos de diagnóstico utilizados na ectopia testicular transversa. A metodologia se caracteriza como uma revisão integrativa da literatura. Foram selecionados artigos na base de dados PubMed/MedLine e Scopus, com critérios específicos de inclusão e exclusão, abrangendo o período até 2023 e utilizando descritores: "Transverse Testicular Ectopia" ; "Crossed Testicular Ectopia" e  "Diagnosis"  ou "Imaging Exams". Como resultados foram encontrados 220 artigos na pesquisa ampla, destes, 25 tinham relação direta com o tema desta revisão, atenderam aos critérios de seleção deste estudo e compuseram a revisão. A revisão abordou métodos de imagem na ectopia testicular transversa, destacando ultrassonografia, tomografia e ressonância magnética. Achados incluem testículos ectópicos em locais anômalos e complicações associadas.Conclui- se que a ectopia testicular transversa, embora rara, é clinicamente relevante, apresentando desafios diagnósticos e terapêuticos. Destaca-se o papel crucial da ultrassonografia, tomografia e ressonância magnética na identificação e caracterização dos testículos ectópicos. Há limitações na disponibilidade de estudos específicos, destacando a necessidade contínua de pesquisa na área.
Elephantiasis and its cure: case report
Authors: Godoy Jose Maria Pereira de , Godoy Henrique Jose Pereira de , Ana Carolina Pereira de Godoy  , Godoy Maria de Fatima Guerreiro
Published: November 2024

Introduction: Lymphedema is a clinical condition stemming from a lymphatic system failure.  The insufficiency of the lymphatic system can causes the abnormal accumulation of protein-rich fluid in the interstitial, which triggers a adverse consequence such a and fibrosis. This study describes a case of a patient who has been cured of elephantiasis for ten years but continues to have lymphedema. Description case:  Patient information: A 78-year-old woman had a history of bilateral lower limb lymphedema, clinical diagnosis that had been worsening throughout her life bilateral despite undergoing treatment and had progressed to stage III (elephantiasis). Clinical findings: The patient was sent to the Clínica Godoy-Sao Jose do Rio Preto-Brazil ten years ago and reported having undergone several forms of treatment, but without impeding the progression of the condition. Therapeutic intervention: The patient was submitted to intensive treatment for three weeks, during which time a 21-kilogram reduction in weight and a 66-cm reduction in circumference occurred. After three weeks, the patient began undergoing treatment at home with laced compression stockings. At the follow-up evaluation, electrical bioimpedance analysis, perimeter measurements and volumetry were performed, which revealed the reduction in lymphedema to standards of normality. The patient has completed 10 years of treatment and has maintained the results using compression stockings. Conclusion: Elephantiasis is curable, but lymphedema is not. Like any other chronic disease, constant treatment is needed to maintain the results.
Estudo da utilização de antimicrobianos durante a pandemia do COVID-19
Authors: Soto Isabelly Gonçalves Garcia , Fernandes Kerollayny Oliveira , Brito Sara Santana Odwyer , Lobo Patrícia Teixeira Damasceno , Chaves Anny Carolinny Tigre Almeida
Published: November 2024

A Organização Mundial da Saúde desencoraja o uso de antibióticos para casos leves de COVID-19, embora o recomende para casos graves com risco aumentado de infecções bacterianas secundárias e morte. Dessa forma, o objetivo deste trabalho foi identificar se houve aumento na utilização dos antimicrobianos em Feira de Santana – Bahia durante a pandemia do COVID-19. Portanto, foi realizada a pesquisa no Portal Brasileiro de Dados Abertos, obtendo-se dados relacionados aos meses de março e agosto dos anos de 2019 e 2020. Os resultados mostraram que houve uma maior saída da amoxicilina no mês de junho de 2020, associada ao crescimento no número de casos que foi da ordem de 321% de casos notificados a mais do que no mês anterior (maio), com mais de 684% de casos positivos para a doença. A azitromicina teve uma saída maior que 670% durante o primeiro pico da pandemia na cidade. A partir da análise dos dados foi evidenciada uma relação proporcional entre o uso de antimicrobianos com o aumento de casos de COVID-19, sendo que o uso de antimicrobianos, em Feira de Santana-BA, aumentou nos anos pesquisados.
Pierfelice Ravenna (1938–2022)—Life, New Names, and Confusion
Authors: García Nicolás , Raven Peter H. , Meerow Alan W.
Published: November 2024

Pierfelice Ravenna was a controversial Chilean botanist active from the late 1960s through the first decade of the 21st century. He died in 2022. During his active years he described ca. 650 species and infraspecific taxa of plants, mostly in Amaryllidaceae and Iridaceae. Unfortunately, the fate of his type specimens, a majority of which were located in his personal herbarium along with many loans from other herbaria, is not clearly known, but by all indications they were destroyed. In this article, we briefly review his life, compile an annotated list of all validly published specific and infraspecific taxa that he described, and determine which have available holotypes and isotypes.
ИННОВАЦИОННАЯ ТЕРАПИЯ РЕВМАТИЧЕСКИХ ЗАБОЛЕВАНИЙ
Authors: Р.Л. Иванова
Published: November 2024

В статье по результатам международного опыта и собственных исследований представлены современные направления в лечении аутоиммунных ревматических заболеваний с использованием генно-инженерных биологических антицитокиновых препаратов, ингибиторов внутриклеточных ферментов – киназ для лечения по принципу «treat to target». Данные этой статьи будут полезны или интересны для интернов, резидентов и врачей – ревматологов, а также для преподавателей медицинских университетов.

Based on the results of international experience and personal research, the article represents modern methods of treatment of autoimmune rheumatic diseases using genetically-engineered anti-cytokine drugs, inhibitors of intracellular enzyme-kinase for treatment on “treat to target” principle. The article findings will be helpful for interns, residents and rheumatologist physicians, as well as teacher of medical universities.

Мақалада халықаралық тәжірибеге және өз зерттеулеріне негізделген аутоиммунды ревматикалық ауруларды заманауи бағытта емдеудің генетикалық инженерлі биологиялық антицитокиндік препараттарды қолдануы, «мақсатты емдеу» принцип бойынша емдеуге арналған жасушааралық ферменттердің ингибиторлары - киназалар көрсетілген. Осы мақаланың деректері интерндерге, резиденттерге және ревматологтарға, сондай-ақ медициналық жоғары оқу орындарының оқытушыларына пайдалы немесе қызықты болады.