bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH KARAKTERISTIK INDIVIDU TERHADAP PRESTASI KERJA MELALUI DISIPLIN KERJA DAN KEPUASAN KERJA
Authors: Riyanto Riyanto , Wiwoho Gunarso
Published: December 2022

This research was conducted to analyze the effect of individual characteristics on work performance with work discipline and job satisfaction as intervention variables. The population of this research was employees at PT Prima Multi Usaha Indonesia with 34 people as sample. The retrieval technique for the sample is saturated sampling. The research instrument of this study was a survey questionnaire which was measured on a 5-level Likert scale. The data obtained were processed by  SPSS (Statistical Product and Service Solution) for Windows version 24.0 to run the descriptive analysis and statistical analysis (path analysis). The results showed that there was a positive effect between individual characteristics on job satisfaction, individual characteristics have a positive effect on work discipline, individual characteristics have a positive effect but not significant to work performance, job satisfaction has a positive effect on work performance, and work discipline has a positive effect on work performance.
Inhibition of Pathogenic Microbes by the Lactic Acid Bacteria Limosilactobacillus Fermentum Strain LAB-1 and Levilactobacillus Brevis Strain LAB-5 Isolated from the Dairy Beverage Borhani
Authors: Hossain Tanim Jabid , Mozumder Halima Akter , Ali Ferdausi , Akther Khadiza
Published: December 2022

Lactic acid bacteria (LAB) with prominent antimicrobial effects against pathogens have been reported in several milk-based and plant-based foods. Borhani is a popular beverage prepared from the ingredients of both dairy and plant origins and is believed to be highly beneficial for health. Herein, we report the pathogen-inhibitory activity of two borhani-associated lactic acid bacteria (LAB), Limosilactobacillus fermentum strain LAB-1 and Levilactobacillus brevis strain LAB-5. Their antimicrobial activity was primarily assessed using the cell free supernatant (CFS) by agar diffusion technique in which both strains showed strong antimicrobial effects against several pathogenic and spoilage microorganisms including Acinetobacter baumannii, Bacillus cereus, Bacillus subtilis, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa, Salmonella abony, Salmonella typhi, Shigella flexneri, and Staphylococcus aureus. The L. fermentum strain with its ability to inhibit all the target pathogens appeared to be more effective with larger inhibition-zone formation as compared to the L. brevis strain which also successfully inhibited all pathogens but had relatively little effects on A. baumannii. The extent of their inhibitory effect was further assessed by co-culture inhibition assay in which growth of the test microbes was monitored for 24 hours in presence of the CFS. The CFS of both lactic acid bacteria could effectively inhibit growth of the pathogenic microbes for a significant period of time. While the L. fermentum strain could almost completely stop growth of all test organisms, the L. brevis strain was particularly effective against Shigella flexneri and the Salmonella species. Our study, therefore, suggests the presence of beneficial lactic acid bacteria in borhani which can be of important use as antimicrobial agents in functional foods and therapeutics to help acquire protection against drug resistant pathogens.
Knowledge, Attitude and Involvement of First-Time Fathers in Infant and Young Child Feeding and Care Practices
Authors: Sachdeva Soni , Gupta Shipra
Published: December 2022

Father’s role is as important as a mother’s in the early years of life to ensure optimum growth and development of the baby. But in most societies, it is often linked with just earning money for the child and the entire family. The present study was undertaken to assess the knowledge, attitude and involvement of first-time fathers in infant and young child feeding and care practices, and their relationship with each other. The influence of select personal and family factors of the fathers was also studied on these aspects. A total of 60 first-time fathers having only one child in the age group of 6 months to 3 years residing in the National Capital Region of India constituted the study sample. A questionnaire schedule was administered to gather information on general and family characteristics, child’s profile, and knowledge, attitudes and involvement of the fathers in infant and young child feeding and care practices. Findings revealed that the total knowledge scores of maximum fathers (43%) were ‘average’. Nearly 60% and 38% fathers respectively had ‘very good’ and ‘good’ total attitude scores. High percentage of fathers had ‘good’ (43%) and ‘very good’ (30%) total involvement scores related to their infant/young child feeding and care practices. A weak but significant positive correlation was found only between knowledge and involvement scores of the fathers (r=0.277, p<0.05). Attitude scores of the fathers were found to be influenced by their occupation while their involvement scores were influenced by their age, and monthly family income. The study indicated that even though the knowledge of the first-time fathers regarding infant and young child feeding practices was average, their attitude regarding these aspects was good, and they also showed a good involvement in these practices. The existing knowledge gaps need to be catered to through suitable timely interventions in order to ensure that fathers can also proactively contribute towards the feeding and care of their infants and young children.
Development of Powdered Mixed Green Tea and Okra Beverage Product by Spray Drying
Authors: Wirivutthikorn Wattana
Published: December 2022

Thai herbal juices tend to lose nutrients during heat processing. Spray-drying has been one of the most well-known methods of powder production, which involves the transformation of liquid material into dried particles. The study performed the suitable conditions of spray drying for green tea and okra powder qualities. Maltodextrin as a carrier at concentrations of 10, 20, and 30 percent were added to mixed green tea and okra powder. Three inlet and fixed outlet temperatures of 150, 160, 170 and 75C, respectively, were also analysed. Physicochemical properties such as colour, moisture, water activity, pH, yield percentage total phenolic and antioxidant inhibition percentage (DPPH, FRAP and ABTS assay) were assessed, while sensory tests were also performed. The inlet temperature of 150C, maltodextrin 10% showed the highest values of the three assays in terms of antioxidant inhibition percentage (DPPH, ABTS (VEAC), (TEAC) and FRAP assays) and total phenolic compound were 0.235%, 0.974 mM/g, 0.696 mM/g, 0.962 mM Fe+2 /g and 0.235 ppm, respectively. A sensory test of each product’s overall acceptability was performed by 30 untrained panelists using the ranking test. The results revealed that the inlet temperature of 150C, maltodextrin 30% was the most accepted (the highest yield percentage), while the inlet temperature of 170C, maltodextrin 30% was the least accepted. The information obtained describes the most exceptional advantages of the spray-drying method for the production of food particles. Further, the potential of this technique and more advanced equipment to develop processes and industrial-scale processes is essential to the bench-to-bedside translation of innovative instant powdered herbal Thai beverage products.
Effects of Physicochemical Characteristics and Storage Stability of Porcine Albumin Protein Hydrolysates in Pork Sausage
Authors: Park Gyutae , Jin Sang-geun , Choi Jungseok
Published: December 2022

In this study, the physicochemical characteristics and storage stability of porcine albumin protein hydrolysates (PAPH) in sausage were evaluated. Four concentrations of PAPH were added to pork emulsion sausage (T1, 0.3%; T2, 0.6%; T3, 0.9%; T4, 1.2%) and compared to the control (CON, 0%). On day 0, proximate composition, cooking loss, and sensory evaluation were compared. Purge loss, color, texture profile analysis, shear force, free amino acids, lipid oxidation, microbial counts, and volatile basic nitrogen (VBN) were compared on day 0 and after 4 weeks of refrigeration. The content of essential amino acids and redness(a*) increased as the level of PAPH added increased (p<0.05). Also, the cooking loss was improved (p<0.05). However, lipid oxidation, microbial counts, and VBN were increased significantly during storage for 4 weeks (p<0.05). The findings indicated that the addition of PAPH improved cooking loss and the protein composition of sausages, but negatively affected storage stability.
The Physicochemical Analysis and Anthocyanin Level of Malaysian Purple Sweet Potato Cracker
Authors: Muhammad Rosmaliza , Ikram Emmy Hainida Khairul , Md. Sharif Mohd Shazali , Md Nor Norazmir
Published: December 2022

Purple Sweet Potato (PSP) in Malaysia is an abandoned crop. Even though it has various health benefits and nutritional values, consumers, especially Malaysians, still lack purple sweet potato consumption. It has a high dietary fibre content, a low glycemic index, and contains proteins, minerals, polyphenols, and anthocyanin. The National Health Morbidity Survey (Malaysia) in 2019 reported that 94% of Malaysian adults lack fiber consumption in their dietary patterns. As a result, it may become an alternative crop for individuals who consume less nutrients and fibre as a result of dietary choices and health issues. This one-of-a-kind crop also contains anti-oxidative, hepatoprotective, anti-inflammatory, anti-tumor, anti-diabetic, anti-microbial, anti-obesity, and anti-aging qualities. Due to the lack of a commercial food product based on this crop, it has become an unpopular crop among Malaysians. Purple sweet potato makes only a few Malaysian sweets and traditional snacks. Nonetheless, Malaysian customers continue to ignore it. Thus, Purple Sweet Potato Cracker was made, and a proximate analysis was conducted to examine its physicochemical content. It was found that the newly developed PSP crackers were high in fiber, vitamins, and minerals, as well as in calcium (1332.08 mg/kg) and contained anthocyanins of 6.68 mg/L. Besides that, this special cracker is free from food preservatives without coloring agents and additives. The processing of Purple Sweet Potato Cracker carries important features for small-medium entrepreneurs, which will contribute to the Malaysian economy perspectives, as it has a good potential to be marketed in domestic and international commercial food outlets.
Inhibition of Colon Cancer Cells Via Apoptosis Pathway by Ethanolic Extract of Andaliman (Zanthoxylum Acanthopodium Dc.) Fruits
Authors: Napitupulu Florensia Irena , Sulistyani Sulistiyani , Prangdimurti Endang , Wijaya Christofora Hanny
Published: December 2022

Andaliman (Zanthoxylum acanthopodium DC.) is an exotic spice from North Sumatra (Indonesia) commonly added to enrich the flavor of Bataknese ethnic food because of its unique aroma and trigeminal sensation. Traditionally, it is also known to have health benefits in the gastrointestinal tract; however no studies have reported it. Therefore, this study aimed to investigate the potency of Andaliman fruit to inhibit the proliferation of HCT-116 and WiDr colon cancer cells and its underlying mechanism of inhibition. Andaliman fruits were extracted using ethanol. The anti-proliferative effect was evaluated using the MTT test, and the underlying mechanism of inhibition was examined using the Real-Time Polymerase Chain Reaction (RT-PCR) and Hoechst staining. Bax and Bcl-2 proteins were used as the markers for the pro-apoptotic and anti-apoptotic gene expression analysis, respectively. Andaliman ethanolic extract showed potential bioactivity to inhibit the growth of WiDr and HCT-116 cells in vitro with IC50 of 95.61 μg.mL-1 and 94.64 μg.mL-1, respectively. The cytotoxicity effect of andaliman was rationalized by the gene expression of Bax and Bcl-2 in a non-dose-dependent manner. In addition, Andaliman extract could increase the apoptotic gene marker expression in both cells at half of their IC50, i.e. 47.81 μg.mL-1 and 47.32 μg.mL-1 for WiDr and HCT-116 cells, respectively. This study demonstrated that Andaliman fruit could be potentially developed as a functional food ingredient to prevent colon cancer by inducing the apoptosis mechanism.
Self-Reported Dietary Habits and Intensity of Negative Emotions: From a Population of Moroccan University Students
Authors: Ihbour Said , Arfaoui Asma , Boulbaroud Samira , Chigr Fatiha
Published: December 2022

Emotional disorders are an ever-increasing problem in our society, accounting for a significant portion of the global burden of disease. A healthy and balanced diet is now one of the promising avenues for the prevention and care of psychiatric disorders. The principal objective of this cross-sectional study was to analyze the relationship between eating habits, frequency of consumption of certain foods, and mental well-being in a sample of students. A food frequency questionnaire was developed to describe participants' eating habits. The DAS21 self-questionnaire was used to assess the intensity of negative emotions associated with depression, anxiety, and stress. The age of the participants, who numbered 620, varied from 18 to 25 years (mean age: 22.32 years). The consumption of the different foods studied was varied, with a low consumption of fruits and vegetables. The prevalence of emotional disorders was high among the students. Skipping breakfast had a negative impact on mental well-being. High frequency of consumption of apples, seafood, kiwi, dried fruits, sardines, olive oil, green leafy vegetables, tomatoes, carrots and apricots was beneficial to the mental health of students. This suggests that healthy eating behaviours based on a balanced diet may be an interesting avenue for preventing and treating psychopathological disorders.
Characterization of Polyphenol Oxidase (PPO) from Blackberry Thorny Wild Rubus Fruticosus and its Inhibition using Natural Extracts
Authors: Azzouzi Naima , Britel Mohammed Reda , Maurady Amal
Published: December 2022

The Polyphenol oxidase (PPO) leads to the enzymatic browning of fruits and vegetables and needs to be prevented in food browning and quality. The present study aimed to investigate the use of natural extracts and chemical inhibitors to prevent browning of the PPO of blackberries. Purification, characterization, and kinetics of PPO of blackberry parameters for five substrates, namely, pyrocatechol, 4-methylcatechol, Pyrogallol, Gallic acid, and tyrosine, were described. The results showed that the DEAE-Sepharose and Superdex G-200 purification methods, which achieved electrophoretic purity, increased PPO activity by 556 fold. Purification with Sephadex GE-200 and SDS-PAGE reveals two PPO isoenzymes with an apparent molecular weight of 22 kD and 70 kD. The optimum pH and temperature values indicated were 6.6 and 25°C, respectively. The PPO showed variable affinity towards o-dihydroxy phenolic substrates with catecholase activity but without any activity observed with phenol, a monohydroxy substrate, and it was very effective towards pyrocatechol, pyrogallol, and 4-methyl catechol. The results revealed that inhibition of the PPO using both synthetic inhibitors and natural extracts was the most effective method. Quercetin and ascorbic acid showed higher inhibition with the lowest Ki values. Fresh onion (Allium cepa) and wild Arbutus unedo extract were able to inhibit the blackberry PPO activity up to 50% and 60%, respectively. Therefore, the use of natural extracts from Arbutus unedo L as anti-browning agents on the blackberry PPO may provide new insight to overcome the enzymatic browning.
Improved arterial stiffness after combined aerobic and resistance training: correlation with heart rate variability change in prehypertensive offspring of hypertensive parents
Authors: Songcharern Nattawut , Ruangthai Ratree , Tumnark Piyaporn , Phoemsapthawee Jatuporn
Published: December 2022

Prehypertensive offspring of hypertensive parents are strongly linked to pathological processes of hypertension in later life. It is observed that young adults with high blood pressure (BP) have increased arterial stiffness, which is linked to autonomic anomalies. The purpose of the present study was to assess the effect of combined resistance and aerobic exercise training on BP, brachial-ankle pulse wave velocity (baPWV), and heart rate variability (HRV) in prehypertensive young men with hypertensive parents. Thirty prehypertensive males aged 19.6 ± 1.2 years were randomly assigned to either a combined exercise training group (CBT, n = 15) or no exercise group (CON, n = 15). The CBT group performed combined exercise for 8 weeks, 3 times per week. BP, baPWV, HRV, peak oxygen consumption (VO2peak), and muscle strength were measured before and after the exercise intervention. Systolic BP (-5.1 mmHg, 3.9% decrease, P < 0.05), diastolic BP (-3.9 mmHg, 6.1% decrease, P < 0.01), mean arterial pressure (-4.2 mmHg, 4.7% decrease, P < 0.05), baPWV (-0.4 m/sec, 3.5% decrease, P < 0.01), standard deviation of all RR intervals (+58.5% increase, P < 0.05) and very low frequency (VLF) (+34.6% increase, P < 0.01), VO2peak (+11.7% increase, P < 0.01) and one-repetition maximum leg press (+30.3% increase, P < 0.01) were significantly improved in the CBT group after 8 weeks of training versus the CON group. Additionally, a reduction in baPWV was associated with an increase in the VLF power of HRV (r= 0.72, P < 0.01). These findings indicate that the combined training improves BP, arterial stiffness, vagal activity, cardiorespiratory fitness, and lower-body muscle strength in prehypertensive offspring of hypertensive parents.
Quality of life and health-promoting lifestyles for parents of children with intellectual and developmental disabilities
Authors: Jeoung Bogja
Published: December 2022

The purpose of this study was to examine the relationship between a health-promoting lifestyle and quality of life in parents of children with intellectual and developmental disabilities. Participants were 254 South Korean parents of children with intellectual and developmental disabilities. We assessed participants using a quality of life scale and the Korean version of the Health-Promoting Lifestyle Profile-II (HPLP-II). The data were analysed using Pearson and Spearman rank correlation analysis, and linear regression was conducted using SPSS ver. 25.0. The results indicated statistically significant associations between health-promoting lifestyles and quality of life in parents of children with intellectual and developmental disabilities. Analysis showed that the HPLP-II subfactors of spiritual growth, health responsibility, exercise, nutrition, interpersonal relations, and stress management could significantly predict quality of life in parents of children with intellectual and developmental disabilities. Healthcare providers should help to improve the quality of life of parents of children with intellectual and developmental disabilities by facilitating health-promoting lifestyle behaviours through interventions designed to increase physical activity, nutrition, stress management, interpersonal relations, health responsibility, and spiritual growth.
Online clinical skills education using a wearable action camera for medical students
Authors: Kwon Oh Young
Published: December 2022

The purpose of this study is to analyze medical students’ satisfaction and educational effectiveness after real-time online clinical skills education using a wearable action camera. One hundred eighteen third-year medical students participated in this study. The education program consisted of clinical skills (wound management and vascular access procedures) and a medical interview with a simulated patient. The author wore the head-mounted action camera throughout the class. A systematic questionnaire survey was issued to the students after the education program to analyze the educational satisfaction and effectiveness. This education program showed their high educational satisfaction. The online environment was also mostly positive except for some negative comments about video quality. In the educational satisfaction, though the comparative satisfaction with the face-to-face skill class was slightly lower, the rest of the questionnaire items also showed high relative satisfaction. Online video education using a wearable camera could be a good modality that can replace a face-to-face class when it is impossible to open the class.
Effect of 8-week high-intensity intermittent running exercise and weight training on muscle and DNA damage in male and female ski major college students
Authors: Lin Chenhong , Sim Young-Je
Published: December 2022

This study assessed changes in blood muscle damage indicators and DNA damage indicators in lymph and urine after 8 weeks of high-intensity intermittent running and weight training in male and female college students majoring in skiing. This study aimed to find an effective training method by investigating differences in the effectiveness between men and women. A total of 20 male and female ski major college students conducted short-term high-intensity intermittent running and weight training in the morning and afternoon, respectively, 3 days a week for 8 weeks for 24 times in total. After 8 weeks of high-intensity intermittent running and weight training, changes in DNA damage indicators in the lymph and urine and muscle damage indicators in the blood were analyzed. The creatine kinase level significantly differed at rest pre-graded exercise testing (GXT) and 60 min of recovery post-GXT after training from that before training between the male and female groups. Although lactate dehydrogenase (LDH) levels decreased in both groups over time, no significant differences in LDH were found between the two groups. Second, DNA 8-hydroxydeoxyguanosine (8-OHdG) in the lymph was significantly different between the two groups at rest pre-GXT and 60 min of recovery post-GXT. 8-OHdG in the urine was significantly lower in the female group only at 60 min of recovery post-GXT. Partial sex differences were found in the reduction of muscle damage and DNA damage after 8 weeks of high-intensity intermittent running and weight training.
Supporting new nurses to improve retention
Authors: Harrison Penny
Published: December 2022

Penny Harrison introduces NHS England's new preceptorship framework for nursing
Use of Gamification in Primary and Secondary Education: A Systematic Literature Review
Authors: Vrcelj Ana , Hoić-Božić Nataša , Dlab Martina Holenko
Published: December 2022

Gamification in education refers to the application of game design elements and game principles in teaching with the goal of increasing students’ motivation and engagement, which contributes to more successful achievement of learning outcomes. Gamification can be used in education at different levels, from primary and secondary schools to universities and adult education. An analysis of the literature on the use of gamification in education has shown that it is more common in university education and less common in primary and secondary schools. Nonetheless, experience shows that games and numerous digital tools are successfully used in schools for the purpose of gamification, although this is generally not supported by the relevant research published in the papers. The research presented in this paper represents a systematic review of the literature on relevant research on the use of gamification in primary and secondary schools to explore the field and make recommendations for future research. The conclusion is that research on gamification should continue to suggest appropriate pedagogical and technological frameworks which would facilitate the use of gamification in schools by teachers.
Assessment of Gaming Addiction and Perceived Psychological Distress Among Filipino Young Adults During COVID-19 Pandemic
Authors: Kapoor Sakshi Kumari , Subida Marietta
Published: December 2022

Online game addiction and psychological distress are two continuously developing problems in the Philippines, with Filipinos aged 18 to 24 being the second largest age group to overuse interactive online-related games. This sequential explanatory mixed method study aimed to assess the young adults’ gaming addiction and perceived psychological distress during the COVID-19 pandemic and identify the other factors contributing to the respondents’ frequent engagement in online interactive games, which served as a basis for a preventive intervention program. The researcher administered the survey questionnaires of the Gaming Addiction Scale and Depression Anxiety Stress Scale-21 to 399 young adults aged 18–24 and a semi-structured interview guide to 20 addicted and non-addicted gamers. Key results showed that a small percentage of the respondents experienced polythetic and serious monothetic addiction to interactive online games. In contrast, half of the respondents manifested mild to moderate symptoms of depression and anxiety during the COVID-19 pandemic. Major findings also found no significant gender differences in the level of online game addiction and psychological distress during the COVID-19 pandemic, and a moderate level of relationship substantiated the association. Further results revealed that the negative compensatory factors were associated with addicted gamers’ frequent engagement with online games, whereas non-addicted gamers were associated with positive, beneficial factors. This phenomenon has hardly ever been the focus of in-depth research, and the results of this study can be used to further refine the conceptualization of “internet gaming disorder” as a mental disorder and develop a more comprehensive treatment method.
Topological super-modes engineering with acoustic graphene plasmons
Authors: Fan Jiang , Sun Zhiguo , Lu Yao , Luo Weiwei , Ren Mengxin , Cai Wei , Xu Jingjun
Published: December 2022

Acoustic graphene plasmons (AGPs) in a graphene-dielectric-metal structure possess extreme field localization and low loss, which have promising applications in strong photon-matter interaction and integrated photonic devices. Here, we propose two kinds of one-dimensional crystals supporting propagating AGPs with different topological properties, which is confirmed by the Zak phase calculations and the electric field symmetry analysis. Moreover, by combining these two plasmonic crystals to form a superlattice system, the super-modes exist because of the coupling between isolated topological interface states. A flat-like dispersion of super-modes is observed by designing the superlattice. These results should find applications in optical sensing and integrating photonic devices with plasmonic crystals.
Design of a dynamic multi-topological charge graphene orbital angular momentum metalens
Authors: Cao Guiyuan , Lin Han , Jia Baohua , Yuan Xiaocong , Somekh Michael , Wei Shibiao
Published: December 2022

Traditional OAM generation devices are bulky and can generally only create OAM with one specific topological charge. Although metasurface-based devices have overcome the volume limitations, no tunable metasurface-based OAM generators have been demonstrated to date. Here, a dynamically tunable multi-topological charge OAM generator based on an ultrathin integrable graphene metalens is demonstrated by simulation using the detour phase technique and spatial multiplexing. Different topological charges can be designed on different focal planes. Stretching the OAM graphene metalens allows the focal plane and the topological values to be changed dynamically. This design method paves an innovative route toward miniaturization and integrating OAM beam-type photonic devices for practical applications.
Synthesis, antimicrobial and molecular docking study of structural analogues of 3-((5-(dimethylcarbamoyl)pyrrolidin-3-yl)thio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Authors: Khaliq Saharish , Khan Mohsin Abbas , Ahmad Irshad , Ahmad Imtiaz , Ahmed Javed , Ullah Farhat
Published: December 2022

The goal of the current work was to create structural analogues of a beta lactam antibiotic that might be possibly effective against bacterial resistant strains. FTIR, 1H NMR, 13C NMR, and CHNS analyses were used to perform the spectroscopic study on the compounds M1–8. The effects of the aforementioned substances on gram-positive and gram-negative bacterial strains were investigated. Most of the eight compounds had antibacterial activity that was lower than or equivalent to that of the original medication, but two molecules, M2 and M3, surprisingly, had stronger antibacterial activity. The findings of synthesized analogues against alpha-glucosidase and DPPH inhibition were found to be modest, whereas M2, M3, and M7 strongly inhibited the urease. To comprehend the potential mode of action, a molecular docking research was conducted against urease and -amylase. The research may help in the quest for novel chemical compounds that would be effective against bacteria that are resistant to antibiotics.
The impact of surgeon’s experience and sex on the incidence of cystoid macular edema after uneventful cataract surgery
Authors: List Wolfgang , Steinwender Gernot , Glatz Wilfried , Riedl Regina , Wedrich Andreas , Ivastinovic Domagoj
Published: December 2022

Purpose

To assess the rate of pseudophakic cystoid macular edema (pCME) in uneventful cataract surgery in surgeons in training vs experienced surgeons and to analyze the rate of pCME according to surgeon’s sex.

Methods

Medical reports post phacoemulsification between 2010 and 2018 at the Department of Ophthalmology, Medical University of Graz, Austria, were reviewed for pCME. A running lifetime number of preceding cataract surgeries was used to express hands-on experience. A cut-off number of 300 surgeries was defined to distinguish between surgeons in training and experienced surgeons. Outcome parameters were incidence of pCME, patient’s sex and age, laterality of eye, coexistence of pseudoexfoliation syndrome (PEX), duration of surgery and surgeon’s sex.

Results

25.422 surgeries on 18.266 patients were included. The majority was performed by experienced surgeons (23.139, 91.0%) vs 2.283 (9.0%) by surgeons in training (25 surgeons, 9 (36%) female and 16 (64%) male). pCME occurred in 32 eyes (1.4%) following surgery by surgeons in training and in 152 eyes (0.7%) following surgery by experienced surgeons. Chance for pCME was 1.57 higher in training surgeries (95% CI 1.03–2.41, p = 0.034) and longer duration (OR = 1.04; 95% CI 1.02–1.07, p = 0.001). After excluding the first 100 surgeries for every surgeon in training similar results were observed. No difference in risk for pCME was found between female and male surgeons in both groups (training and experienced surgeons).

Conclusion

In conclusion, the rate for pCME after uneventful cataract surgery is significantly higher for surgeons in training but steadily decreasing and associated to surgical time. No difference in the risk for pCME was found between female and male surgeons.
A Simple and Validated Stability Indicating HPLC Method for
Simultaneous Quantification of Brimonidine, Timolol and
Benzalkonium Chloride in Anti-Glaucoma Ophthalmic Formulations
Authors: Pawar A. Krishnamanjari , Mannepalli Chandana
Published: December 2022

The combined dosage form of brimonidine, timolol and benzalkonium chloride is prescribed for
lowering intraocular pressure in patients with ocular hypertension. As no analytical HPLC method
reported for the estimation of brimonidine, timolol and benzalkonium chloride together in ophthalmic
formulations, the present study was aimed to fulfill the gap identified in literature. The separation of
analytes was achieved on Cosmosil C18 (250 × 4.6 mm; 5 μ id) as stationary phase, pH 4.3 acetate
buffer and methanol in 30:70 (v/v) as mobile phase at 1.0 mL/min and UV detection at 227 nm. In this
condition, well resolved, retained peaks were identified at 3.11 min for brimonidine, 4.86 min for
timolol and 5.57 min for benzalkonium chloride. The method reports 0.5, 1.25 and 0.0125 μg/mL,
respectively for brimonidine, timolol and benzalkonium chloride as LOD, which proves that the method
have enough sensitivity levels for the detection analytes in samples. The method passes all the validation
parameters as per the guidelines proved that the method was valid. The method shows less % degradation
in various stress studies such as acidic, base, peroxide, thermal and UV light conditions and can
effectively separate various stress degradation compounds and confirms the stability indicating nature
of the method. The method applicability was assessed by analyzing the drug content in Combigan®
ophthalmic drops and method reports the assay of 98.92%, 99.36% and 98.46% for brimonidine,
timolol and benzalkonium chloride, respectively. Based on the results, it can be concluded that the
method can adequately suitable for the separation and quantification of brimonidine, timolol and
benzalkonium chloride and hence can be applicable for the routine analysis of brimonidine, timolol
and benzalkonium chloride in ophthalmic formulations.
Vaucheria coronata and V. velutina – new species of the yellow-green algae of the Xanthophyceae for the Arkhangelsk Region (White Sea)
Authors: Moseev Dmitry S. , Berezina Marina O. , Sergienko Ludmila A. , Churakova Elena Yu. , Leshchev Andrey V.
Published: December 2022

The article provides information about two species of the yellow-green algae – Vaucheria coronata and V. velutina. Vaucheria coronata was found on the Solovetsky Islands and is the secondly recorded for the species in Russia and for the first for the Arkhangelsk Region. Vaucheria velutina is indicated for the first time for the White Sea. A brief description of the localities and habitats of growth and general distribution of these species is given. Morphological features of the studied specimens are given.
Tailored Treatment Based on Helicobacter pylori Genetic Markers of Resistance Is Associated With Higher Eradication Success
Authors: Cummings Linda C. , Hojat Leila S. , Nguyen David C. , Stempak Lisa M. , Rhoads Daniel D. , Sadri Navid
Published: December 2022

INTRODUCTION:

Increasing antimicrobial resistance with Helicobacter pylori infection has focused efforts to tailor eradication therapy based on identifying genetic markers of resistance to predict antimicrobial susceptibility.

METHODS:

In this retrospective study, we report the effect of routine inclusion of antimicrobial susceptibility testing and recommendations for eradication therapy with gastric specimens with H. pylori.

RESULTS:

The use of a recommended treatment regimen based on genetic markers of resistance was associated with an 84% rate of eradication success and 4.4 greater odds of eradication relative to unrecommended treatment.

DISCUSSION:

This is the first study describing the use of H. pylori genetic resistance testing as standard of care.
User Expectations on Telemedicine Financing in the National Health Insurance Era
Authors: Budiyanti Rani Tiyas , Suryawati Chriswardani , Murni Murni , Hanifah Matsna
Published: December 2022

Telemedicine users have increased during the Covid-19 pandemic. Telemedicine can provide alternative solutions to improving quality, and access, and reducing disparities in health services, especially in urban and remote areas. However, in the era of national health insurance, not all telemedicine is covered by Healthcare and Social Security Agency (BPJS Kesehatan). This study aims to determine user expectations of telemedicine financing in the national health insurance era. This research is quantitative research with a descriptive approach which was conducted in February-April 2022. The respondents were 102 people who had used telemedicine services in Indonesia that were selected through the quota sampling method. The results showed that 95.1% of respondents agreed that telemedicine services were covered by the National Health Insurance (NHI), either fully or by sharing costs. As many as 31.95% of respondents expect 25% of cost-sharing with NHI, 35.05% of respondents expect 50% of cost-sharing with NHI, 12.37% of respondents expect 80% of cost-sharing with NHI, and 20.63 % hope 100% will be covered by NHI. Further and specific regulation related to telemedicine is needed. The type of telemedicine service covered communication with the telemedicine service provider, and the amount of the service fee covered needs to be communicated between the relevant parties
Alkohol w społeczeństwie polskim i polska polityka publiczna wobec alkoholu na przestrzeni dziejów. Pomiędzy piwnym wolnym rynkiem a spirytusowym monopolem
Authors: Obłąkowska Katarzyna Agnieszka , Bartoszewicz Artur
Published: December 2022

Artykuł podejmuje problematykę przemian wzorów spożywania przez Polaków napojów alkoholowych (piwo, wino, napoje spirytusowe) na przestrzeni dziejów oraz wzorów prowadzonej przez państwo polskie polityki alkoholowej. Przeprowadzona przez autorów analiza wykazała, że można wyodrębnić etapy w tych dziejach, które zostały nazwane w następujący sposób: 1) Piwo i wino dominują do XV w.; 2) Pojawienie się wódki w XVI w. i wzrost jej konsumpcji; 3) Wódka z ziemniaków degraduje naród od XIX w.; 4) Monopol państwowy w XX w. zwiększa spożycie; 5) Nowa polityka alkoholowa od 1982 r. – ku trzeźwości narodu; 6) Działania kontr produktywne w XXI w.; 7) Współczesność – Polacy piją szkodliwie, a polityka publiczna RP wobec alkoholu przynosi negatywne wyniki. W artykule przedstawiono te etapy, a także sformułowano rekomendacje dla polityki alkoholowej Rzeczypospolitej Polskiej wobec zdiagnozowanej jej nieskuteczności od 2001 do 2019 roku. Jako istotny obszar dla współczesnej polityki społeczno-gospodarczej w obszarze alkoholu wskazano m.in. e-commerce napojów alkoholowych.
Various coding techniques under bit sequence generators operation mode effects for upgrading transceiver systems efficiency
Authors: Zaki Rashed Ahmed Nabih , Babu Gade Harish , Sujaro Lakkepogu , Ahammad Shaik Hasane , Hossain Md. Amzad , Mohammed Abd Elnaser A.
Published: December 2022

This paper has outlined the simulation study of different operation mode for bit sequence generators variations effects on the transceiver systems efficiency with Manchester coding/decoding technique. The eye diagram signal analyzer after the light receiver is clarified in different mode operation of bit sequence generators. The different mode operation are namely probability, order, alternate, zeros, and ones modes. As well as the received signal amplitude after low pass Bessel filters is examined in different modes operation-based bit sequence generators. Available transmission data rates for this study are 10 Gb/s. The obtained results assured that the system coding performance efficiency is enhanced with alternate mode operation than other proposed modes operation-based bit sequence generators.
Refining explanation in Evolutionary Phonology: macro-typologies and targeted typologies in action
Authors: Blevins Juliette , Egurtzegi Ander
Published: December 2022

In this paper, we highlight the role of typology in providing an empirical basis for explanation within Evolutionary Phonology with a focus on rare sound patterns and extra-phonetic explanation. Broad typological surveys of sound patterns or macro-typologies that include phonetic detail may, at once, support universal tendencies and document rare sound patterns, offering arguments for theories in which universal tendencies based on phonetic explanation are emergent properties of markedness-free grammars. However, in order to explain rarity and explore extra-phonetic factors, targeted typologies, narrowed by specific structural properties or contact histories, may be necessary. In this study, the complementary roles of broad and targeted typologies are illustrated through recent case studies of three basic components of phonological systems—sound inventories, alternations, and phonotactics—, with a focus on non-phonetic explanations that have enhanced the predictive power of the Evolutionary framework.
Research on Suicide in Muslim majority countries: A bibliometric analysis
Authors: Arafat S.M. Yasir
Published: December 2022

Objectives. A bibliometric analysis of suicide would identify the potential research gaps in Muslim majority countries. For that purpose, the present study reviews articles on suicide in Muslim majority countries.

Methods. The Scopus database was searched to identify publications from inception to the search date using search terms.

Results. The search identified 154 articles published from 1970 to 2022 with a recent increase in the number of papers. The highest number of papers was published from Iran (38), followed by Bangladesh (32) and Turkey (23). No studywas found from 28 Islamic States. The highest number of papers was published by the Aga Khan University of Pakistan, followed by the Enam Medical College and Hospital of Bangladesh and theTehran University of Medical Sciences. The greatest number of papers (n=9) was published in the Asian Journal of Psychiatry, followed by the Iranian Journal of Psychiatry and Behavioral Sciences (n=7), and the Crisis (n=5).

Conclusion. This analysis revealed that there is an extreme dearth of research on suicide in Muslim countries becausemore than half of the countries do not have published articles listed in Scopus.
Dynamic Formation of Quality Expectations: Theory and Empirical Evidence
Authors: Fruchter Gila E. , Reutterer Thomas , Dickert Stephan , Vacondio Martina
Published: December 2022

The evolution of quality expectations over time is an important driver of customer satisfaction and retention. This study investigated the dynamic properties of customers’ quality expectation updating from an analytical perspective and provides new evidence on the psychological correlates of the discrepancies between expectations and experiences in the realm of consumer decision making. In doing so, we focus on the dynamics of expectation formation by adopting a nonlinear complex systems approach based on well-established behavioral theories. Using stability analysis, we find analytical results which are supported empirically by an experiment that there is considerable heterogeneity in how consumers calibrate their quality expectations. Specifically, we demonstrate analytically that in some cases individuals will converge to a specific quality expectation (reach a stable fixed point), while in other cases their expectations will oscillate between a small number of points periodically. This is remarkable because the existence of the latter is not due to changes in quality performance but merely accrue endogenously and depend on individuals’ disconfirmation functions. To our knowledge, this is the first time in the marketing literature that the corresponding gaps between quality expectations and quality provided are analyzed in the long run. Our analytical and empirical findings also suggest that being more responsive to a person’s expectations can increase the portion of those individuals that are able to better calibrate. Finally, we also demonstrate that calibration ability is associated with how thoughtful or impulsive information is used to update one’s expectation. A more deliberative processing style, which includes using a wider range of information, seems to be related to fewer unrealistic expectations and better calibrations, while a more impulsive processing style is related to more unrealistic expectations. In addition to providing a better understanding of dynamic expectation formation, these results can pave the way for interventions that foster more accurate quality expectations. From a managerial perspective, our findings imply that communicating quality perceptions are only to a certain extent under managerial control. To recognize this, firms are advised to segment customers based on their information processing style and to customize their marketing actions accordingly.
Comparison with molecular effects of ukrain, tamoxifen, and docetaxel on human breast cancer cell lines
Authors: Abusoglu Gulsum , Kocak Cengiz , Kocak Fatma Emel , Ozturk Bahadır , Vatansev Husamettin
Published: December 2022

Objectives

Our aim was to compare the cytotoxic effects of tamoxifen and docetaxel, currently used in breast cancer treatment, and ukrain, which demonstrates antiproliferative properties on breast cancer cells.

Methods

MCF-7 and MDA MB-231 cells were treated with various doses of docetaxel, tamoxifen, and ukrain. The cytotoxic effects of all drugs were determined with the cell empedance technique. Cell blocks were prepared from cultured and drug-exposed cells for histopathological and immunohistochemical determinations of Ki-67, Bcl-2, Bax, and Cyclin-D1 expressions.

Results

According to comparisons of proapoptotic and antiapoptotic protein expression indices, no statistically significant difference was found between the effects of ukrain and docetaxel in both cell lines. Although tamoxifen was more effective than ukrain in MCF-7 cells, ukrain was also more effective than tamoxifen in MDA MB-231 cells for inducing apoptosis.

Conclusions

Although ukrain presented antiproliferative and apoptotic effects on both cell lines, MDA MB-231 cells were more vulnerable to the effects of ukrain. The findings suggest that ukrain might be a useful therapeutic agent, especially for treating receptor-negative breast cancer cells.
Ebussuûd Efendi nin Galatât-ı Avâm ına Şehrî Mustafa Şevket Tarafından Yazılan Şerh
Authors: İnan Göker
Published: December 2022

Bu çalışmada Ebussuûd Efendi’nin (ö. 982/1574) Türkçe olarak kaleme aldığı kısa bir risale olan Galatât-ı Avâm adlı esere Şehrî Mustafa Şevket (ö. 1291/1874) tarafından yazılan şerh ele alınmıştır. İlk olarak, 38 yaşında vefat eden ve akademik çalışmalarda hayatı hakkında ayrıntılı bir bilgiye rastlanmayan şarih hakkında bir biyografi denemesi yapılmış, ardından Arap dili ve İslâmî ilimler konusunda geniş bilgi sahibi olduğu anlaşılan Mustafa Şevket’in şerhteki açıklamaları incelenerek galat kavramıyla ilgili görüşleri değerlendirilmiştir. Şarih bu risalesinde hatalı kullanılan bazı kelimelerin gerekçelerini ayrıntılı dilbilgisi kaideleri ile yazarken önemli bir kısmını da kısaca geçiştirmiş; böylelikle eserini halktan ziyade iyi seviyede Arapça sarf bilgisine sahip kişilere hitaben yazdığını göstermiştir. Diğer taraftan gerekli gördüğü yerlerde Arapça kelimelerin Türkçe karşılıklarını da vermiş ve Ebussuûd Efendi’ye katılmadığı noktalarda itirazlarını dile getirmiştir. Şerhi boyunca müracaat ettiği lügatlerdeki alternatif harekelendirmeleri de dikkate alan Mustafa Şevket, galatların doğru kabul edilebilecek farklı okunuşları noktasında katı bir duruş sergilememiş, kelimelerin kullanıldığı zaman ve zemin içerisinde farklı anlamlar kazanabileceği görüşünü ise kısmen benimsemiştir.