bluuebunny/crossref_metadata_2025 huggingface dataset:
The Therapeutic Effect of Shark Liver Oil in a Rat Model of Acetic Acid‐Induced Ulcerative Colitis
Authors: Samimi Nastaran , Sepehrimanesh Masood , Koohi-Hosseinabadi Omid , Homayounfar Reza , Mokhtari Maral , Farjam Mojtaba
Published: October 2020

Ulcerative colitis (UC) is one of the most well‐known types of inflammatory bowel disease that manifests as recurrent inflammation of rectum and colon. The goal of this study is to evaluate the protective effects of shark liver oil (SLO) on acetic acid‐induced ulcerative colitis in rats. Eighty induced UC rats were randomly divided into ten equal groups and received the following treatments for seven days: 1 ml of normal saline rectally, 1 ml of gel base (carboxymethyl cellulose) rectally, 10 mg/kg of Asacol rectally, 10 mg/kg of mesalazine orally, 5% gel form of SLO rectally, 10% gel form of SLO rectally, 200 mg of SLO orally, and 400 mg of SLO orally. We examined the oxidative stress indices, histopathological features, and body weight changes, as well as the function of the liver and kidneys at the end of treatment. Administration of 10% rectal and 400 mg oral SLO resulted in a significant weight gain. Also, glutathione peroxidase activity was significantly higher in 5% and 10% SLO‐treated groups, and elevated superoxide dismutase activity in rats that received 5% SLO was observed compared to negative control and Asacol groups. While no significant changes were observed in most of the kidney and liver function markers, higher levels of aspartate aminotransferase were detected in the group that received 400 mg SLO orally compared to negative control and Asacol groups. Many histopathological signs of improvement were observed in mesalazine, Asacol, and SLO groups. There were no significant changes detected in the mean rank among different groups. Our data indicate that SLO supplementation could improve the amelioration of acetic acid‐induced UC in rats due to its antioxidant effects.
A Double‐Blinded, Randomized, Vehicle‐Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L‐Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population
Authors: Kulthanan Kanokvalai , Trakanwittayarak Suphattra , Tuchinda Papapit , Chularojanamontri Leena , Limphoka Pichaya , Varothai Supenya
Published: October 2020

Many topical agents are available for treating the acute phase of acne; however, few agents have been proven beneficial during the maintenance phase. Objective. To evaluate the efficacy and safety of moisturizer containing licochalcone A, 1,2‐decanediol, L‐carnitine, and salicylic acid during the maintenance phase of mild to moderate acne in Thai patients. Methods. One hundred and ten patients with mild to moderate acne vulgaris were initially treated with a fixed combination of adapalene 0.1%/benzoyl peroxide 2.5% gel once daily for 8 weeks. Fifty patients who achieved at least 50% reduction in lesion counts or at least a 2‐grade improvement in the Investigator’s Global Assessment (IGA) grade from baseline were enrolled in the maintenance phase, which was an investigator‐masked, left‐right comparison, randomized, controlled, intraindividual study. Moisturizers with and without the active study ingredients were applied twice a day to each side of the face, respectively, for 12 weeks. Assessments included acne lesion counts, acne severity by IGA scoring, skin bioengineering measurements, and skin tolerability as assessed by both patient and physician. Results. The treatment group had a significant reduction in the mean counts of noninflammatory, inflammatory, and total lesions compared to the vehicle group at week 12 and also between baseline and week 12. There was no significant difference in the mean scores for skin dryness, stinging/burning, or pruritus at any time point between groups. Conclusions. Moisturizer containing licochalcone A, 1,2‐decanediol, L‐carnitine, and salicylic acid reduced acne lesions and prevented the development of new lesions during the maintenance phase. This trial is registered with ClinicalTrials.gov registration no. NCT04002024.
Goiter and Its Associated Factors among Adolescent High School Girls at Tach Armachiho District, Northwest Ethiopia: An Institution-Based Cross-Sectional Study
Authors: Mesfin Belaynew , Misganaw Bisrat , Hunegnaw Melkamu Tamir , Muhammad Esmael Ali
Published: October 2020

Introduction. In Ethiopia, iodine deficiency disorder (IDD) is a major public health problem. The most visible effect of IDD is the appearance of goiters, and 28 million people are affected by goiter. Therefore, this study aimed to assess the prevalence and associated factors of goiter among high school adolescent girls at Tach Armachiho district, Northwest Ethiopia. Methods. An institution-based cross-sectional study was conducted from October to November 2018. A total of 620 high school adolescent girls were selected using the simple random sampling technique, and structured questionnaires having observational check-list were used for data collection. The presence of goiter was estimated using criteria set by World Health Organization. Iodine content of the salt was estimated by using spot testing kits. Both bivariable and multivariable logistic regressions were used to identify associated factors. The degree of association between independent and dependent variables was assessed by using odds ratio with 95% confidence interval. Those variables having

p

value of less than 0.05 in the multivariable analysis were considered as significant factors for goiter. Results. A total of 614 adolescent girls gave a complete response. The prevalence of goiter among adolescent girls was 24.1%. In the multivariable logistic regression analysis, age of adolescent girls (adjusted odds ratio (AOR) = 1.57, 95% CI: 1.01–2.46), residence (AOR = 1.91, 95% CI: 1.04–3.51), family history (AOR = 4.96, 95% CI: 3.19, 7.72), low dietary diversity (AOR = 8.39, 95% CI: 4.36–16.14), and medium dietary diversity (AOR = 2.26, 95% CI: 1.36–3.77) were significantly associated with adolescent girls goiter. Conclusions. Goiter among high school adolescent girls in this study was high. Age of adolescent, residence, family history of goiter, and dietary diversity were statistically significant factors for goiter. Therefore, more emphasis will be given for late adolescent age, having family history of goiter, low dietary diversity, and rural residence to improve the burden of adolescent goiter.
Digital vs. Freehand Anterior Single‐Tooth Implant Restoration
Authors: Baldi D. , Colombo J. , Motta F. , Motta F. M. , Zillio A. , Scotti N.
Published: October 2020

Replacing a single tooth in the anterior maxilla is one of the greatest challenges in dentistry. Both functional and aesthetic results are to be strictly pursued. Planning and executing such a case through a totally digital methodology eventually guarantee many advantages, above all patient’s operative and postoperative comfort. To ascertain this, a BOP analysis was performed which allowed us to evaluate soft tissues health, and more; crestal bone resorption was measured to evaluate hard tissues stability. This assumption was studied through four cases in which patients were alternatively treated with analogic and digital techniques. Four homogeneous patients were recruited. They all needed to extract one of the upper incisors, due to different clinical reasons, and then to replace it with an implant. Each patient was treated with an immediate postextractive implant which was immediately loaded, and finally, analogical and digital techniques were compared. All patients underwent a preoperative CBCT examination. After surgery, patients were checked by the surgeon after 10 days and one month to evaluate the progress of healing and to exclude any prosthetic problem. At 6 months (T1), one year (T2), and three years (T3), intraoral x‐rays were performed using customized centring devices, according to the parallel beam technique. All data have been collected in a table and statistically processed; mean and standard deviation were measured. All patients entered an oral hygiene program with six months recall. Dental hygienist checked the BOP at T1, T2, and T3. At every step, similar levels of BOP were recorded. About interproximal bone loss, all patients showed an initial moderate loss (between T1 and T2), followed by stable values between T2 and T3. Despite the important limitations of a study with few cases, these results show a similar outcome comparing digital and analogical methods.
In Vitro Characterization of Multilamellar Fibers with Uniaxially Oriented Electrospun Type I Collagen Scaffolds
Authors: Hooshmand-Ardakani Alireza , Talaei-Khozani Tahereh , Sadat-Shojai Mehdi , Bahmanpour Soghra , Zarei-fard Nehleh
Published: October 2020

Fabrication of an appropriate scaffold is critical in order to recapitulate the architecture and functionality of the native tissue. In this study, we attempted to create favorable collagen fiber alignment and multilamellar with uniaxially oriented layers, using a disc collector by turning mats 90 degrees horizontally at specific times. Different concentrations of rat tail‐derived type I collagen (3, 6, 8% w/v) in 1,1,1,3,3,3‐hexafluoroisopropanol (HFIP) are used for electrospinning affairs. The 6% w/v collagen at an applied voltage of 20 kV and collector rotation of 2500 rpm was selected to exhibit bead‐free homogeneous nanofiber with fiber thickness of 0.14 ± 0.4 µm, maximum thickness of 0.5 ± 0.08 µm, and 60% porosity. Also, scanning electron microscope images of electrospun fibers showed 3D multilamellar scaffold with the goodness of 96.5% ± 0.8 in each aligned uniaxially oriented fiber layer. Cross‐linking of collagen fibers with N‐(3‐dimethylaminopropyl)‐N0‐ethylcarbodiimide hydrochloride (EDC)/N‐hydroxysuccinimide (NHS) reduced the fiber degradation rate and preserved the fiber morphology and alignment. The multilamellar mat showed significant increase in tensile strength and average breaking elongation in comparison with unilamellar mat. In vitro cell culture, using human adipose tissue‐derived mesenchymal stem cells (hAT‐MSCs) on cross‐linked scaffold, showed improvement in cell proliferation, attachment, migration, and intercellular junction with a flattened morphology. Raman spectra revealed the preservation of collagen structure. In addition, Raman spectra of the cell containing scaffold were the same as those of an intact intervertebral disc as a sample to be used in engineering tissues. In conclusion, our results showed that the 3D multilamellar collagen nanofibrous scaffold is more appropriate for the tissues that have multilamellar structure.
Research on Cutting Characteristics of Rock Plate with Two Sides Fixed and Two Sides Free
Authors: Lu Zhenguo , Zeng Qingliang , Liu Zhihai , Gao Guanshun , Zhong Peisi
Published: October 2020

Conical pick wear is an urgent problem in the roadway excavation caused by hard rock difficult to break. The traditional method of increasing cutting power to improve cutting performance of conical pick significantly increases pick wear. In the paper, a saw blade and conical pick combined cutting method is proposed based on increased free surface. To research the fracture morphology and cutting force of rock plate, theoretical, numerical, and experimental methods are used. By theoretical research, the bending mechanical model of rock plate bending is established. The cutting position and the junction between the free sides and fixed sides are preferentially broken. A numerical model combining the erosion and damage constitutive model is built, and the cutting process of rock plate was presented. According to rock plate experiment, the peak cutting force increases with the increasing uniaxial compressive strength, thickness of rock plate, and cutting depth of conical pick and decreases with the increasing width and height of rock plate. Exponential relationships exist between peak cutting force and thickness, width and height of rock plate, and cutting depth of conical pick. Linear relationship exists between peak cutting force and uniaxial compressive strength. The size of rock fragments increases with uniaxial compressive strength, width, and height of rock plate.
Perception of Ghanaian Primigravidas Undergoing Their First Antenatal Ultrasonography in Cape Coast
Authors: Edzie Emmanuel Kobina Mesi , Dzefi-Tettey Klenam , Gorleku Philip Narteh , Ampofo James William , Piersson Albert Dayor , Asemah Abdul Raman , Kusodzi Henry , Edzie Richard Ato
Published: October 2020

Ultrasound scans have become an essential requirement of pregnancy care in countries with developed health services and increasingly being used in medical practice in Ghana as well. The aim of this study was to find out the perception of primigravidas experiencing antenatal ultrasonography for the first time in Cape Coast. This was a descriptive, prospective study which employed the use of a questionnaire to obtain data from 384 consented respondents, who were primigravidas experiencing antenatal ultrasonography for the first time in three selected public health facilities in Cape Coast Metropolis over a six-month period. Sociodemographic data, reasons for undergoing antenatal ultrasound, their expectations, knowledge in fetal abnormalities, and suggestions to help improve their future experiences were collected. The data were analyzed using SPSS software, version 20.0 (SPSS Inc., Chicago, IL, USA). Out of a total number of 384 respondents, 87.8% of them knew about what ultrasound is used for. 87.5% scanned because a doctor or midwife requested for the scan whilst 53.9% scanned to check for fetal abnormalities. 98.4% indicated that ultrasound scanning has positive effects on pregnancy outcome. An expensive service was stated as a negative reason that would influence the decision to undergo the examination next time; nonetheless, 90.4% would recommend it to other women and suggested showing the fetus on monitor while scanning and providing accurate findings would make their future experiences better. The perception of the primigravidas was largely positive. Checking for fetal abnormalities was a major reason for the scans, although their knowledge in specific fetal abnormalities was low. They expected to know the fetal sex, but that was not a major reason for scanning. Showing them the monitor was the most frequent suggestion to make future experience better.
A Novel Approach towards Bipolar Soft Sets and Their Applications
Authors: Mahmood Tahir
Published: October 2020

The notion of bipolar soft sets has already been defined, but in this article, the notion of bipolar soft sets has been redefined, called T-bipolar soft sets. It is shown that the new approach is more close to the concept of bipolarity as compared to the previous ones, and further it is discussed that so far in the study of soft sets and their generalizations, the concept introduced in this manuscript has never been discussed earlier. We have also discussed the operational laws of T-bipolar soft sets and their basic properties. In the end, we have deliberated the algebraic structures associated with T-bipolar soft sets and the applications of T-bipolar soft sets in decision-making problems.
Analyzing Machine Learning Models with Gaussian Process for the Indoor Positioning System
Authors: Xie Yunxin , Zhu Chenyang , Jiang Wei , Bi Jia , Zhu Zhengwei
Published: October 2020

Recently, there has been growing interest in improving the efficiency and accuracy of the Indoor Positioning System (IPS). The Received Signal Strength- (RSS-) based fingerprinting technique is essential for indoor localization. However, it is challenging to estimate the indoor position based on RSS’s measurement under the complex indoor environment. This paper evaluates three machine learning approaches and Gaussian Process (GP) regression with three different kernels to get the best indoor positioning model. The hyperparameter tuning technique is used to select the optimum parameter set for each model. Experiments are carried out with RSS data from seven access points (AP). Results show that GP with a rational quadratic kernel and eXtreme gradient tree boosting model has the best positioning accuracy compared to other models. In contrast, the eXtreme gradient tree boosting model could achieve higher positioning accuracy with smaller training size and fewer access points.
Characteristic of Clinical Studies on Baduanjin during 2000–2019: A Comprehensive Review
Authors: Zhou Jing , Yu Yunyang , Cao Biwei , Li Xiaoya , Wu Miao , Wen Tao , Xiong Yuan , Jia Jian , Zhao Yan
Published: October 2020

To date, a growing number of clinical studies have demonstrated the safety and health benefits from Baduanjin intervention. Based on this, our objective is to systematically retrieve and summarize the clinical studies on Baduanjin, with a view to providing more evidence‐based evidence in support of the application of Baduanjin for healthcare, and to identify the shortcomings of existing research and provide feasibility suggest for further clinical research. Both four English language and four Chinese language electronic databases were used to search articles related to Baduanjin during 2000–2019. SPSS 22.0 software was used to analyze the data, and the risk of bias tool in the RevMan 5.3.5 software was used to evaluate the methodological quality of randomized controlled trials. A total of 810 publications were identified, including 43 (5.3%) systematic reviews, 614 (75.8%) randomized controlled trials, 66 (8.1%) nonrandomized controlled clinical studies, 84 (10.4%) case series, and 3 (0.4%) case reports. The top 10 diseases/conditions included diabetes, chronic obstructive pulmonary disease, hypertension, low back pain, neck pain, stroke, coronary heart disease, cognitive impairment, insomnia, and osteoporosis or osteopenia. The style of State General Administration of Sport of China in 2003 was the most commonly used version of Baduanjin, and Baduanjin was practiced with an average of 35 minutes, 1 or 2 times a day, 3–5 days per week, and a 18‐week average duration. It is also worth noting that there were no serious adverse events related to Baduanjin intervention. Most studies were small sample size research, and the methodological quality of randomized controlled trials is generally low. The clinical studies of Baduanjin have a substantial quantity and evidence base. However, there are significant differences among different studies in the specific intervention measures such as style, intensity, duration, learning, and practice methods, which need to be further standardized and unified. Further high‐quality designed and reporting studies are recommended to further validate the clinical benefits of Baduanjin.
A Simple Framework of Smart Geriatric Nursing considering Health Big Data and User Profile
Authors: Li Shijie , Tang Yongchuan
Published: October 2020

The National Bureau of Statistics of China shows that the population over 65 years old in China exceeds 166 million accounting for 11.93% of the total population by the end of 2018. The importance and severity of taking care of the elderly are becoming increasingly prominent. High-quality and meticulous care for the daily life of the elderly needs helpful and advanced sciences and technologies. Smart geriatric nursing is a must. Basing on the professional knowledge of geriatric nursing, this paper proposes a framework of smart geriatric nursing which consists of three aspects of smart nursing: smart geriatric nursing in physical health using biosensor and advanced devices, smart geriatric nursing in mental health based on user profile, and smart geriatric nursing for daily life based on big data in health. The deployment of the proposed method relies on the technologies of the Internet of Things (IoT), user profile system, big data, and many other advanced information technologies. The framework of methods can provide a useful reference for the systematic technical scheme of smart geriatric nursing in an aging society.
Research on the Impact and Mechanism for the Inhibition of Micrococcus Catalase Activity by Typical Tetracyclines
Authors: Ren Luyao , Wang Qian , Du Yonggang , Xu Pengju , Zong Wansong
Published: October 2020

As potential inhibitors target to biological enzymes, antibiotics may have certain impacts on the biochemical treatment process. With micrococcus catalase (CAT) served as the target molecule, the impact and inhibition mechanism for typical tetracyclines (TCs) were evaluated. Toxicity experiments showed that TCs had significant inhibition on CAT in the sequence of tetracycline>chlortetracycline>oxytetracycline>doxycycline. To clarify the inhibition mechanism between TCs and CAT which was explored with the assistance of fluorescence spectroscopy and MOE molecule simulation. According to fluorescence analysis, TCs quenched the fluorescence signal of CAT by the mode of static quenching. Combined with toxicity data, it could be presumed that TCs combined with the catalytic active center and thus inhibited CAT. Above presumption was further verified by the molecular simulation data. When TCs combined with the catalytic center of CAT, the compounds have increased combination areas and prominent energy change (compared with the compounds formed by TCs and noncatalytic center recommend by MOE software). IBM SPSS statistics showed that TC toxicity positively correlated with the hydrogen bonds such as O13→Glu252, O1←Arg195, and O6→Asp249, but negatively correlated with the hydrogen bonds such as O10→Pro363, O10→Lys455, and O12 → Asn127. TC toxicity also positively correlated with the ion bonds ofN4‐Glu252, but negatively correlated with the ion bonds of N4‐Asp379. Hydrogen bonds and ion bonds for above key sites were closely related to the inhibition effect of TCs on CAT.
SVD-CNN: A Convolutional Neural Network Model with Orthogonal Constraints Based on SVD for Context-Aware Citation Recommendation
Authors: Tao Shaoyu , Shen Chaoyuan , Zhu Li , Dai Tao
Published: October 2020

Context-aware citation recommendation aims to automatically predict suitable citations for a given citation context, which is essentially helpful for researchers when writing scientific papers. In existing neural network-based approaches, overcorrelation in the weight matrix influences semantic similarity, which is a difficult problem to solve. In this paper, we propose a novel context-aware citation recommendation approach that can essentially improve the orthogonality of the weight matrix and explore more accurate citation patterns. We quantitatively show that the various reference patterns in the paper have interactional features that can significantly affect link prediction. We conduct experiments on the CiteSeer datasets. The results show that our model is superior to baseline models in all metrics.
FOXP3 in Melanoma with Regression: Between Tumoral Expression and Regulatory T Cell Upregulation
Authors: Cioplea Mirela , Nichita Luciana , Georgescu Daniela , Sticlaru Liana , Cioroianu Alexandra , Nedelcu Roxana , Turcu Gabriela , Rauta Alin , Mogodici Cristian , Zurac Sabina , Popp Cristiana
Published: October 2020

Cutaneous melanoma is a significant immunogenic tumoral model, the most frequently described immune phenomenon being tumor regression, as a result of the interaction of tumoral antigens and stromal microenvironment. We present a retrospective cohort study including 52 cases of melanoma with regression. There were evaluated correlations of the most important prognostic factors (Breslow depth and mitotic index) with FOXP3 expression in tumor cells and with the presence of regulatory T cells and dendritic cells in the tumoral stroma. FOXP3 expression in tumor cells seems an independent factor of poor prognosis in melanoma, while regression areas are characterized by a high number of dendritic cells and a low number of regulatory T cells. FOXP3 is probably a useful therapeutical target in melanoma, since inhibition of FOXP3-positive tumor clones and of regulatory T cells could eliminate the ability of tumor cells to escape the immune defense of the host.
Assessment of the Antibacterial Effects of Bismuth Nanoparticles against Enterococcus faecalis
Authors: Azad Azita , Rostamifar Sahar , Modaresi Farzan , Bazrafkan Ali , Rezaie Zahra
Published: October 2020

Introduction. Enterococcus faecalis (E. faecalis) is the most important species in dentistry and plays a significant role in the etiology of persistent apical lesions after root canal treatment. Up to date, the intracanal application of 2% chlorhexidine for 7 days is the best way to eliminate E. faecalis. However, due to the ability of this bacterium to persist and survive in harsh environments, many studies have been directed towards finding an alternative strategy for prevention or eradication of it. This study was conducted to investigate the effect of bismuth nanoparticles on E. faecalis, as an etiologic factor in recurrent root canal infections. Methods. Forty patients, referred to Endodontic Ward of Shiraz University of Medical Science for endodontic pretreatment, provided root canal samples. First, all samples were transferred in Enterococcosel broth and incubated. Then, samples which showed growth were plated on blood agar plates and incubated for further PCR procedure. Nanoparticle powder was dissolved in high‐purity water, and the final concentration of bismuth nanoparticles (BiNPs) was measured by the spectrophotometer. Minimum inhibitory concentration (MIC) of BiNPs against E. faecalis was determined by microbroth dilution method according to methods for antimicrobial susceptibility tests. Also, bactericidal assays were conducted in Mueller‐Hinton broth medium and reported as the concentration of BiNPs that reduced the viable bacterial count by 99.9%. Results. Of all samples, 77.5% revealed the presence of E. faecalis by PCR. Also, E. faecalis growth inhibition was observed at concentrations ranging from 0.625 μg/ml to 20 μg/ml (geometric mean: 2.337 μg/ml), and the MBC values were between 1.25 μg/ml and 40 μg/ml (geometric mean: 4.781 μg/ml), which in comparison with chlorhexidine, these values were about one‐eighth of chlorhexidine. Conclusion. The experimental data suggest that bismuth nanoparticles could be an interesting alternative to combat E. faecalis, which, in view of the advantages mentioned for bismuth nanoparticle like inhibiting Streptococcus mutans biofilm formation and higher antibacterial activity compared to chlorhexidine, can be suggested to be used in different fields of dentistry.
Industry Development of Derivative Functionalized Gold Nanomaterials and Their Application in Chemiluminescence Bioanalysis: Based on the Industrial Practice of China's Central Yunnan Urban Agglomeration
Authors: Ma Tengfei , Wu Hao
Published: October 2020

Electrochemiluminescence biosensor is an analytical method combining electrochemiluminescence technology with biosensor. Using nanomaterials as electrochemical luminescence sensor platform can not only immobilize a large number of biomolecules but also improve the performance of the sensor to realize the supersensitive detection of biomacromolecules. Although these methods have high sensitivity for bioanalysis, there are still some shortcomings which limit the practical application. Therefore, this paper discusses the development of functional gold nanomaterials industry and its application in chemiluminescence bioanalysis. In this paper, two methods of synthesizing luminescent functional gold nanomaterials at room temperature were studied by using chemiluminescent reagents as reducing agent and protective agent. Based on luminescent functionalized gold nanoparticles, immunoassay and DNA bioanalysis probes were constructed, and their applications in chemiluminescence and electrochemiluminescence bioanalysis were discussed. Finally, the simulation results show that the relative deviation between the experimental results and the existing clinical methods is less than 17%. The sensor has good stability and selectivity and can be used for the determination of CEA in human serum. The gold nanomaterials synthesized by further research have excellent chemiluminescence activity and can be used to label biomolecules and prepare biological probes. This article aims to explore the application of chemical methods in the transformation of new industries, to achieve breakthroughs in new products in industrial innovation, and to achieve the cross-fusion of management science and engineering disciplines and chemical disciplines. The industrial development of derivative functionalized gold nanomaterials has broad application prospects in biological analysis.
Run or Die: A Didactique Case Report of a Rare Cause of Lactic Acidosis in Emergency Medicine
Authors: Bouillon-Minois Jean-Baptiste , Schmidt Jeannot , Dutheil Frédéric
Published: October 2020

Introduction. Acidosis with traumatic brain injury is a common and serious cause of consciousness disorders in emergency medicine. Extreme acidosis is significantly associated with high mortality (more than 67% if pH levels are under 7). Case Presentation. We describe the case of a 23-year-old man with unknown medical history who was found near the entrance of the emergency department sweat with a tachypnea (55 per minute), a lot of blood around him, and confused. The initial hypothesis was a hemorrhagic shock after a fight, but he did not have any hemodynamic trouble. The initial venous gazometry showed a major lactic acidosis (pH less than 6,8, HCO3 incalculable and lactate up to 20 mmol/L). A Focused Assessment with Sonography in Trauma-echography (FAST-echo) and secondly a body-tomodensitometry were conducted and did not reveal any anomaly. The team was now thinking that the patient situation was caused by an epileptic seizure (association of lactic acidosis and confusion), and the bleed was a consequence of the head trauma. The patient was treated only by NaCl 0,9%. One hour after his admission, the tachypnea began to decrease and he could speak and explain what was happen. He had to run as fast as possible to escape to a fight. The last gazometry, realized 2 hours after his admission, finds a normal pH at 7,35, HCO3 24,5 mmol/L and lactate 2,6 mmol/L. He was authorized to going home. Conclusion. We report here a rare case of major lactic acidosis in emergency medicine caused by a supramaximal effort.
Single Magnetic Element-Based High Step-Up Converter for Energy Storage and Photovoltaic System with Reduced Device Count
Authors: Arif Muhammad , Shahzad Mohsin , Li Qianmu , Saleem Jawad , Aslam Muhammad Shamrooz , Majid Abdul
Published: October 2020

The multiport DC-DC power converter is a prominent area of research in power electronics due to its highly dense design, reduced device count, and high energy efficiency. In this paper, a nonisolated single magnetic element-based high step-up three-port converter for an energy storage system is presented. The proposed converter has two input ports and one output port. The coupled inductor with switched capacitor is used to achieve high voltage gain. The key features of the proposed converter are high conversion gain, low voltage stress, zero voltage switching (ZVS), and zero current switching (ZCS). The detailed theoretical analysis and operation of the converter are elaborated. The energy efficiency of the proposed converter is calculated and compared with the other counterparts. Ansys Maxwell is used for the coupled inductor finite element modeling. To verify the applicability and functionality of proposed converter, a

100
 W

converter with two inputs (

48
 V

and

96
 V

) and one output

360
 V

at

100
 kHz

is tested in the laboratory.
Blow-Up Solutions for a Singular Nonlinear Hadamard Fractional Boundary Value Problem
Authors: Bachar Imed , Mesloub Said
Published: October 2020

We consider singular nonlinear Hadamard fractional boundary value problems. Using properties of Green’s function and a fixed point theorem, we show that the problem has positive solutions which blow up. Finally, some examples are provided to explain the applications of the results.
Hepatoprotective Effects of Aqueous Extract of Opilia celtidifolia (Opiliaceae) Leaves against Ethanol‐Induced Liver Damage in Rats
Authors: Amang A. P. , Kodji E. , Mezui C. , Baane M. P. , Siwe G. T. , Kuissu T. M. , Emakoua J. , Tan P. V.
Published: October 2020

Objective. Opilia celtidifolia is a plant used in Cameroonian ethnomedicine to cure jaundice. The aim of this study was to evaluate the hepatoprotective activity of O. celtidifolia leaves aqueous extract in rats subjected to ethanol‐induced liver damage. Material and Methods. 36 rats including 18 males and 18 females were divided into 6 groups of 3 males and 3 females each, namely, 3 control groups (normal, negative, positive) and 3 test groups. The normal and negative control groups were given distilled water (5 ml/kg), the positive control group received silymarin (100 mg/kg), and the test groups were given O. celtidifolia extract at the doses of 100, 200, and 400 mg/kg. All groups, except the normal control, received concomitantly and daily 40% ethanol (4 g/kg) for 3 weeks to induce hepatotoxicity. Biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), bilirubin, and lipid profile (total cholesterol, HDL, LDL, and triglycerides) were evaluated. Histological sections of the liver, kidneys, and lungs were examined. Qualitative and quantitative phytochemical analysis of the extract were carried out. Results. The groups treated with the extract at the doses of 200 and 400 mg/kg showed a significant decrease (p < 0.001) of transaminases (ALT and AST), ALP, and bilirubin compared with the negative control. These results were confirmed by observation of histological sections of the liver that confirmed protective action of extract against ethanol‐induced hepatocellular injury. Conclusion. O. celtidifolia possesses hepatoprotective properties that could be related to its high content of tannins and saponins in the leaves aqueous extract.
Multivariate Inverted Kumaraswamy Distribution: Derivation and Estimation
Authors: Aly Hanan M. , Abuelamayem Ola A.
Published: October 2020

Industrial revolution leads to the manufacturing of multicomponent products; to guarantee the sufficiency of the product and consumer satisfaction, the producer has to study the lifetime of the products. This leads to the use of bivariate and multivariate lifetime distributions in reliability engineering. The most popular and applicable is Marshall–Olkin family of distributions. In this paper, a new bivariate lifetime distribution which is the bivariate inverted Kumaraswamy (BIK) distribution is found and its properties are illustrated. Estimation using both maximum likelihood and Bayesian approaches is accomplished. Using different selection criteria, it is found that BIK provides the best performance compared with other bivariate distributions like bivariate exponential and bivariate inverse Weibull distributions. As a generalization, the multivariate inverted Kumaraswamy (MIK) distribution is derived. Few studies have been conducted on the multivariate Marshall–Olkin lifetime distributions. To the best of our knowledge, none of them handle estimation process. In this paper, we developed an algorithm to show how to estimate the unknown parameters of MIK using both maximum likelihood and Bayesian approaches. This algorithm could be applied in estimating other Marshall–Olkin multivariate lifetime distributions.
Hadamard-Type
k
-Fractional Integral Inequalities for Exponentially

α
,
h
−
m

-Convex Functions
Authors: Jung Chahn Yong , Farid Ghulam , Bibi Sidra , Nisar Kottakkaran Sooppy , Kang Shin Min
Published: October 2020

The class of exponentially

α
,
h
−
m

-convex functions has been discovered to unify different kinds of convexities. This paper finds new Riemann–Liouville fractional Hadamard-type inequalities for this generalized class of convex functions. These results further have their consequences which are presented in the form of corollaries. Moreover, some known results are identified in the form of remarks.
Zagreb Connection Numbers for Cellular Neural Networks
Authors: Liu Jia-Bao , Raza Zahid , Javaid Muhammad
Published: October 2020

Neural networks in which communication works only among the neighboring units are called cellular neural networks (CNNs). These are used in analyzing 3D surfaces, image processing, modeling biological vision, and reducing nonvisual problems of geometric maps and sensory-motor organs. Topological indices (TIs) are mathematical models of the (molecular) networks or structures which are presented in the form of numerical values, constitutional formulas, or numerical functions. These models predict the various chemical or structural properties of the under-study networks. We now consider analogous graph invariants, based on the second connection number of vertices, called Zagreb connection indices. The main objective of this paper is to compute these connection indices for the cellular neural networks (CNNs). In order to find their efficiency, a comparison among the obtained indices of CNN is also performed in the form of numerical tables and 3D plots.
A Computing Model for Quantifying the Value of Structural Health Monitoring Information in Bridge Engineering
Authors: Cheng Baoquan , Wang Lijie , Huang Jianling , Shi Xu , Hu Xiaodong , Chen Huihua
Published: October 2020

Structural health monitoring system can provide valuable information for improving decision-making process in maintenance and management of bridges. However, managers usually lack understanding of value of structural health monitoring information. This paper developed a computing model for quantifying the value of structural health monitoring information based on Bayesian theory. Then, the model was demonstrated and validated using a simple case and the key factors (i.e., system accuracy, reparation cost, prior probability of structural failure, and manager’s behavior pattern) influencing the value of structural health monitoring information were identified and discussed. Findings from this study help to answer the question of whether a structural health monitoring system should be installed and run, thus enriching the knowledge body of structural health monitoring.
Bleb Morphology Using Anterior-Segment Optical Coherence Tomography after Ahmed Glaucoma Valve Surgery with Tenon Capsule Resection
Authors: Wagdy Faried M.
Published: October 2020

Objectives. To evaluate the internal morphology of blebs using anterior-segment optical coherence tomography (AS-OCT) and the surgical outcomes of Ahmed glaucoma valve (AGV) surgery with Tenon capsule resection compared to conventional AGV surgery in patients with refractory glaucoma. Patients and Methods. This randomised prospective study included 30 eyes from 30 patients (age range: 42–55 y) with refractory glaucoma from March 2018 to February 2020. The study included two groups: AGV with the Tenon capsule resection group (n = 15) and the conventional AGV surgery group (n = 15). Follow-up continued until 6 months after surgery. The primary outcome was intraocular pressure (IOP) and its association with the number of postoperative glaucoma medications, best corrected visual acuity, visual field, and postoperative complications. The internal morphology of the blebs in both groups was evaluated at 1-day, 1-week, 1-month, 3-month, and 6-month follow-up using AS-OCT in terms of the consequent changes in bleb wall thickness, bleb wall reflectivity, and bleb cavity morphology throughout the 6-month follow-up period. Results. A significant reduction in IOP was found in both groups, with a greater reduction in group I, where the mean IOP decreased from 32.73 ± 2.12 mmHg in the preoperative period to 13.33 ± 1.59 mmHg after 6 months, whereas in group II, the mean IOP decreased from 33.2 ± 2.21 mmHg in the preoperative period to 14.27 ± 1.44 mmHg after 6 months (

p

value <0.05). The difference between the 2 groups in terms of the decrease in IOP was insignificant except at 1 and 3 months, where there was a significant difference (

p

value = 0.016 and 0.01 at 1 and 3 months, respectively). The bleb analysis revealed a significant reduction in the wall thickness in both groups at 1 and 3 months, which was mostly associated with the hypertensive phase. In group I, the bleb wall thickness decreased from 754.67 ± 53.93 μm in the first postoperative day to 684 ± 81.66 μm and 671.6 ± 69.48 μm at 1 and 3 months, respectively, while in group II, the bleb wall thickness decreased from 707.13 ± 31.7 μm in the first postoperative day to 499.53 ± 99.1 μm and 506 ± 76.91 μm at 1 and 3 months, respectively. There was a significant reduction in AS‐OCT, and bleb reflectivity was insignificant throughout the follow-up period (

p

value >0.05). Regarding postoperative complications, the hypertensive phase occurred more frequently in group II (6 eyes, 40%) than in group I (2 eyes, 13.3%). Other complications were also reported more frequently in group II such as hypotony, shallow anterior chamber (AC), and tube exposure. Conclusion. AS-OCT was beneficial in the analysis of bleb morphology after AGV surgery where there were more diffuse functioning multicystic blebs and less thinning in the bleb wall thickness during the hypertensive phase after resection of the Tenon capsule, which might be related to the less incidence of fibrosis around the surgical site.
A Novel Label-Free Biosensor for Detection of HE4 in Urine Based on Localized Surface Plasmon Resonance and Protein G Directional Fixed
Authors: Duan Ruiqi , Xi Mingrong
Published: October 2020

A non-invasive and more sensitive method for detection of HE4 is very important for the early screening and detection of ovarian carcinoma. In this study, we improved our previous localized surface plasmon resonance (LSPR) biosensor for detection of HE4 in urine to overcome disadvantages of conventional methods. Protein G directional fixed method was firstly used for LSPR biosensor to improved sensitivity, and standard HE4 and clinical samples were detected separately using this new biosensor. Compared to our previous LSPR biosensor, this new sensor was more sensitive, with other advantages as before. Under optimum conditions, this new biosensor could display a detection limit of 1 pM and wide dynamic range of 1 pM to 10,000 pM. This new biosensor was effective for detection of HE4 in urine of early ovarian cancer patients, without label and purification. To the best of our knowledge, this is first work to investigate LSPR biosensor for detection of tumor marker in urine, with great advantages and clinical application potentials.
Prediction of Dynamic Modulus of Hot Mix Asphalts with Reclaimed Asphalt Pavement
Authors: Hossain Zahid , Zaman Musharraf
Published: October 2020

This study evaluated the viscoelastic properties of a performance grade (PG) binder blended with different percentages of binders recovered from reclaimed asphalt pavement (RAP) for conditions (materials, climate, and specifications) prevailing in Oklahoma. The viscoelastic properties of the blended binders were then used to estimate dynamic modulus (E∗) values of the new mixes with RAP by using the Witczak model through time‐temperature superposition (TTS) principles. The recovered binder from RAP was found to be significantly stiffer than the virgin binder (PG 64‐22). The addition of RAP increased the complex modulus (G∗) of the base binder, so did the E∗ of the corresponding mix. The creep stiffness resistance of the asphalt binder at low service temperatures decreased with the addition of RAP. With up to 10% RAP binder, no notable changes were observed in the viscosity and PG grade of the virgin binder. With 25% and 40% RAP binder, the PGs of the blended binders were found to be PG 70‐16 and PG 76‐16, respectively. It was observed that the E∗ master curves predicted from PGs of the blended binders were in close agreement with those estimated from the laboratory‐measured E∗ data. The dynamic shear rheometer (DSR) data of rotational thin film oven (RTFO)‐aged blended binders predicted significantly lower E∗ values compared to the measured ones. The E∗ values predicted from rotational viscosity (RV) test data were found to be higher than the measured E∗ values. The findings of this study are expected to provide transportation professionals with a better understanding of new mixes with high RAPs.
An Improved Sign Language Translation Model with Explainable Adaptations for Processing Long Sign Sentences
Authors: Zheng Jiangbin , Zhao Zheng , Chen Min , Chen Jing , Wu Chong , Chen Yidong , Shi Xiaodong , Tong Yiqi
Published: October 2020

Sign language translation (SLT) is an important application to bridge the communication gap between deaf and hearing people. In recent years, the research on the SLT based on neural translation frameworks has attracted wide attention. Despite the progress, current SLT research is still in the initial stage. In fact, current systems perform poorly in processing long sign sentences, which often involve long-distance dependencies and require large resource consumption. To tackle this problem, we propose two explainable adaptations to the traditional neural SLT models using optimized tokenization-related modules. First, we introduce a frame stream density compression (FSDC) algorithm for detecting and reducing the redundant similar frames, which effectively shortens the long sign sentences without losing information. Then, we replace the traditional encoder in a neural machine translation (NMT) module with an improved architecture, which incorporates a temporal convolution (T-Conv) unit and a dynamic hierarchical bidirectional GRU (DH-BiGRU) unit sequentially. The improved component takes the temporal tokenization information into consideration to extract deeper information with reasonable resource consumption. Our experiments on the RWTH-PHOENIX-Weather 2014T dataset show that the proposed model outperforms the state-of-the-art baseline up to about 1.5+ BLEU-4 score gains.
System Design for Opportunistic Spectrum Access Using Statistical Decision-Making and Coded-MAC
Authors: Rodriguez-Colina Enrique , Marcelín-Jiménez Ricardo , Palacios-Luengas Leonardo , Pascoe-Chalke Michael
Published: October 2020

Different mechanisms have been proposed to solve opportunistic spectrum access (OSA). In order to address spectrum management efficiently, these mechanisms can be divided into four main functionalities, spectrum sensing, decision-making, sharing, and mobility. These functionalities depend on the interpretation and adaptation of different parameters, for example, sensing and data interpretation for adaptive modulation, power adjustments, and changes regarding the range of frequency operation. For the decision-making function, a novel approach is proposed in which coding information is added to the establishment of the communication process thus assisting the medium access control (MAC). The presence of cognitive radio devices in the network coverage range can be controlled or coordinated by using specific redundancy codes. Hence, Reed Solomon (RS) code is used in this paper as part of the handshaking process to provide error correction. In addition, a redundancy strategy based on Rabin’s information dispersal algorithm (IDA) is presented to provide fault tolerance to the communication between cognitive radio devices. In this case, the information is divided into fragments dynamically, and each fragment is coded by an RS code and reassigned to a subset of recipients using alternate paths. This work shows how to optimize spectrum access based on IDA and RS codes to diversify channel occupation without losing significant information with several frequency hops presented in cognitive radio communications. The validations were executed in a discrete event simulator developed in Python. The proposed system for OSA was found to perform better than other approaches using pilot sequences. Our proposal, therefore, provides fault tolerance, to diversify channel occupation, and helps identify the presence of primary and secondary users when a common control channel (CCC) is implemented by the optimization of the spectrum use.