bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH PEMBERIAN MINUM JAHE MERAH TERHADAP PENURUNAN INTENSITAS NYERI LUKA PERINEUM PADA IBU NIFAS
Authors: Herawati Ita , Ikrar Faderiani Septi
Published: November 2023

Pendahuluan : WHO menyebutkan sebanyak 2,7 juta ibu bersalin mengalami rupture perineum dan akan terjadi peningkatan hingga 6,3 juta di tahun 2050. Di Asia angka kejadian ruptur perineum mencapai 50% kasus sedangkan di Indonesia 85% ibu bersalin secara normal mengalami rupture perienum. Dampak yang ditimbulkan dari ruptur perineum itu adalah nyeri yang dirasakan oleh ibu pada daerah perineum. Salah satu cara non farmakologi untuk mengurangi nyeri adalah dengan meminum jahe merah karena jahe sama efektifnya dengan asam mefenamat dan ibuprofen untuk mengurangi segala nyeri pada wanita termasuk nyeri pada luka perineum. Tujuan Penelitian : Mengetahui pengaruh pemberian jahe merah terhadap penurunan intensitas nyeri luka perineum pada ibu nifas Metode Penelitian : Quasi eksperimental dengan rancangan two group pretest-posttest design. Sampel dalam penelitian ini adalah seluruh ibu nifas di Desa Cariu Bogor pada bulan Desember 2022  sebanyak 34 orang, teknik pemgambilan sampel yaitu total sampling. Hasil Penelitian : Intensitas nyeri luka perineum sebelum diberikan minum jahe merah sebagian besar responden mengalami nyeri sedang (61,8%) dan sesudah diberikan minum jahe merah sebagian besar mengalami nyeri ringan (64,7%). Ada pengaruh pemberian jahe merah terhadap penurunan intensitas nyeri luka perineum pada ibu nifas (p.value 0,000). Kesimpulan dan Saran : Ada pengaruh pemberian jahe merah terhadap penurunan intensitas nyeri luka perineum pada ibu nifas. Diharapkan bidan dapat meningkatkan pelayanan dalam melakukan penatalaksanaan nyeri luka perineum pada ibu nifas.
FAKTOR -FAKTOR YANG MEMPENGARUHI IBU HAMIL MENOLAK BERHUBUNGAN SEX DI PUSKESMAS KUTABUMI KABUPATEN TANGERANG TAHUN 2022
Authors: Fatimah Siti , Achmad Fauzi
Published: November 2023

Pendahuluan: Banyak wanita yang mengalami masa kehamilan tanpa perubahan yang jelas pada gairah atau keinginan seksual. Beberapa faktor yang mempengaruhinya yaitu kondisi fisiologi, psikologi dan mitos dalam kehamilan.Tujuan: Mengetahui faktor-faktor yang mempengaruhi ibu hamil menolak berhubungan sex di Puskesmas Kutabumi Kabupaten Tangerang Tahun 2022. Metode Penelitian: Penelitian ini merupakan penelitian analitik kuantitatif dengan rancangan cross sectional. Sampel dalam penelitian ini adalah ibu hamil trimester III yang melakukan kunjungan ke Puskesmas Kutabumi Kabupaten Tangerang sebanyak 95 responden dengan teknik total sampling. Data dianalisis menggunakan uji statistik Chi Square. Hasil: Hasil analisis univariat sebagian besar ibu hamil trimester III dengan tidak menolak ibu hamil berhubungan sex sebanyak 55,8%, kondisi fisik ibu hamil bagus sebanyak 57,9%, kondisi psikologi ibu hamil negatif sebanyak 60,0%, dan mitos dalam kehamilan percaya sebanyak 66,7%. Hasil analisis bivariat diketahui bahwa ada hubungan yang signifikan antara kondisi fisik (p value = 0,015), kondisi psikologis (p value = 0,000) dan mitos (p value = 0,000) dengan ibu hamil menolak berhubungan sex. Kesimpulan: Ada hubungan yang signifikan antara kondisi fisik, kondisi psikologis dan mitos dengan ibu hamil menolak berhubungan sex.
HUBUNGAN PENGETAHUAN DAN PENDIDIKAN TERHADAP PENGGUNAAN GARAM BERYODIUM PADA IBU HAMIL
Authors: Sarah Siti , Elfira Sri Futriani
Published: November 2023

Pendahuluan: WHO tahun 2019 menjelaskan bahwa sekitar 810 ibu hamil meninggal setiap harinya disebabkan komplikasi kehamilan dan persalinan. Komplikasi utama yang menyebabkan hampir 75% dari semua kematian ibu hamil di dunia yaitu perdarahan, infeksi, preeklamsia dan aborsi tidak aman. Ibu hamil memerlukan berbagai nutrisi untuk menjaga kesehatan kehamilannya, seperti yodium untuk mendukung pertumbuhan dan perkembangan janin, terutama pembentukan otak dan sistem saraf yang sehat. Tujuan Penelitian : untuk mengetahui hubungan antara pengetahuan dan pendidikan terhadap penggunaan garam beryodium pada ibu hamil. Metode Penelitian : Analitik kuantitatif dengan menggunakan rancangan cross sectional. Sampel dalam penelitian ini adalah seluruh ibu hamil di Kampung Tambun Sungai Angke RW. 06 Desa Pahlawan Setia pada bulan November 2022 sebanyak 35 responden. Teknik pengambilan sampel dalam penelitian ini menggunakan teknik total sampling. Hasil Penelitian : Sebagian besar ibu hamil menggunakan garam beryodium 62,9%, pengetahuan baik 60% dan pendidikan menengah 48,6%. Ada hubungan antara pengetahuan ibu hamil terhadap penggunaan garam beryodium (p.value 0,000). Ada hubungan antara pendidikan ibu hamil terhadap penggunaan garam beryodium (p.value 0,015).  Kesimpulan dan Saran : Ada hubungan antara pengetahuan dan pendidikan ibu hamil terhadap penggunaan garam beryodium. Diharapkan tenaga kesehatan lebih sering lagi memberikan penyuluhan tentang pentingnya konsumsi garam yang beryodium ke masyarakat.
PENGARUH AROMATERAPI CITRUS LIMON TERHADAP KESEHATAN MENTAL MAHASISWA SELAMA PANDEMI COVID-19
Authors: Sitti Khadijah  , Palifiana Dheska Arthyka , Amestiasih Tia , Amalinda Cicilia
Published: November 2023

Perubahan yang dialami mahasiswa selama pandemi Covid-19 berpotensi terhadap terganggunya kesehatan mental mahasiswa. Masalah kesehatan mental yang meningkat di masa pandemi adalah stress, kecemasan, bahkan depresi, berkaitan dengan perubahan proses perkuliahan dan kehidupan sehari-hari. Aromaterapi merupakan salah satu metode nonfarmakologis untuk membantu memperbaiki atau menjaga kesehatan, membangkitkan semangat, menyegarkan serta menenangkan jiwa dan raga. Aromaterapi minyak Lemon (Citrus Limon) bisa meningkatkan mood, merelaksasikan pikiran dan meningkatkan konsentrasi. Tujuan penelitian ini adalah untuk mengetahui efektivitas aromaterapi citrus limon terhadap kesehatan mental mahasiswa selama pandemi Covid-19. Jenis penelitian yang akan dilaksanakan adalah penelitian kuantitatif dengan desain penelitian Experimental berupa Pre-Post Test Design With Control Group. Aromaterapi citrus limon diberikan selama 1 bulan. Penilaian kesehatan mental dilakukan 2 kali, sebelum dan sesudah pemberian aromaterapi. Hasil analisis didapat bahwa pemberian aromaterapi citrus limon hanya memberikan efek pada kategori kecemasan dimana terdapat perbedaan bermakna antara sebelum dan setelah diberikan aromaterapi citrus limon.
HUBUNGAN PENGETAHUAN PERAWAT TENTANG KEBUTUHAN SPIRITUAL DENGAN PERILAKU PERAWAT DALAM PEMENUHAN KEBUTUHAN SPIRITUAL PASIEN
Authors: Ramadhani Hanum Rachman , Suratmi Suratmi , Qowi Nurul Hikmatul
Published: November 2023

Latarbelakang:. Pemenuhan kebutuhan spiritual belum dilakukan secara maksimal oleh perawat. Survey awal yang dilakukan di salah satu Rumah Sakit Lamongan menunjukkan bahwa 17 (85%) perawat jarang memberikan intervensi dalam pemenuhan kebutuhan spiritual sehari-hari pasien dan 3 (15%) diantaranya masih menganggap bahwa pemenuhan kebutuhan spiritual bukan tugasnya melainkan tugas dari keluarga dan tim rohaniawan serta lebih mengutamakan kebutuhan fisiologis dibandingkan dengan kebutuhan spiritual. Tujuan: Untuk mengetahui hubungan pengetahuan perawat tentang kebutuhan spiritual dengan perilaku perawat dalam pemenuhan kebutuhan spiritual pasien. Metode: Penelitian ini menggunakan metode analisis korelasi dengan pendekatan cross sectional, yaitu variabel independen dan variabel dependen dikumpulkan dalam satu waktu dan setelah data penelitian terkumpul dilakukan uji distribusi frekuensi dari kedua variabel dan di lanjutkan uji spearman rank untuk mengetahui ada atau tidaknya hubungan diantara kedua variabel. Pengambilan sampel menggunakan teknik cluster sampling di dapatkan 94 responden. Instrumen yang digunakan variabel independen kuesioner pengetahuan pemenuhan kebutuhan spiritual Sinaga (2014), variabel dependen kuesioner NSCTS (Nurse Spiritual Care Theurapeutic Scale) (Mamier et al, 2018). Hasil: Pengetahuan perawat tentang kebutuhan spiritual sebagian besar baik sebanyak 84 perawat (89,4%) dan sebagian besar memiliki perilaku dalam pemenuhan kebutuhan spiritual sedang sebanyak 65 perawat (69,1%). Penelitian ini menggunakan program SPSS 16.0 For Windows menggunakan uji spearman rank dengan nilai =0,05 diperoleh nilai =0,000 yang artinya ada hubungan pengetahuan perawat tentang kebutuhan spiritual dengan perilaku perawat dalam pemenuhan kebutuhan spiritual pasien. Kesimpulan: perawat diharapkan dapat memberikan pelayanan berupa rujukan kerohaniawan agar pemenuhan kebutuhan spiritual pasien tetap terpenuhi dengan baik. Evaluasi pemenuhan kebutuhan spiritual juga perlu dilakukan secara kontinyu untuk perbaikan pelayanan kesehatan
LITERATURE REVIEW: HUBUNGAN DIABETES MELITUS DENGAN KEJADIAN GAGAL GINJAL KRONIK
Authors: Suherman  , Sopiah Popi , Ridwan Heri
Published: November 2023

Pendahuluan: Ginjal merupakan organ krusial yang mendukung kinerja tubuh manusia yang memiliki peranan penting untuk tubuh manusia mulai dari menjaga cairan dalam tubuh, mengeluarkan zat-zat yang sudah tidak dibutuhkan, serta menghasilkan zat-zat yang berguna bagi tubuh. Kelainan nefropati diabetik merupakan komplikasi kapiler disebabkan penyakit diabetes melitus yang kemudian akan mengakibatkan gagal ginjal kronik yang mengganggu keseimbangan cairan dalam tubuh. Tujuan: penulisan ini guna mengetahui gambaran hubungan diabetes melitus dengan kejadian gagal ginjal kronik. Metode: Penulisan ini berbentuk literature review dengan proses pencarian jurnal menggunakan mesin pencari google scholar dan harzhing publish or perish 8 dengan batasan rentang tahun 2013-2023 serta menggunakan kata kunci diabetes melitus dan gagal ginjal kronik. Hasil: Didapatkan 7 jurnal yang kemudian dianalisis dan semuannya menyatakan bahwa ada hubungan antara diabetes melitus dengan kejadian gagal ginjal kronik. Kesimpulan: Dengan demikian dapat disimpulkan bahwasannya diabetes melitus memang ada hubungannya dengan kejadian gagal ginjal kronik baik sebagai pencetus maupun sebagai penyakit penyerta.
PENERAPAN MIRROR THERAPY UNTUK MENINGKATKAN KEKUATAN OTOT PADA PASIEN STROKE DI RSUP FATMAWATI: STUDI KASUSDI RSUP FATMAWATI
Authors: Putri Lika Eka , Wasilah Hinin
Published: November 2023

Latarbelakang: Prevalensi stroke secara global menurut WHO (World Health Organization) ada 13,7 juta kasus stroke setiap tahunnya dan 5,5 juta diantaranya meninggal dunia pada tahun 2019. Tujuan: Mendapatkan gambaran pelaksanaan mirror therapy untuk meningkatkan kekuatan otot pada klien dengan stroke. Metode: Rancangan studi kasus ini adalah deskriptif dengan pendekatan asuhan keperawatan. Subjek studi kasus ini terdiri dari 2 orang pasien stroke. Pengumpulan data dilakukan melalui wawancara, observasi, dan pemeriksaan fisik khususnya pengukuran kekuatan otot. Hasil: Hasil studi kasus ini menunjukkan adanya peningkatan kekuatan otot pada subjek pertama dan kedua masing-masing dengan nilai 5 dan 4 setelah tindakan, sedangkan sebelum tindakan diperoleh nilai 4 dan 3. Mirror therapy dilakukan selama 3 hari dengan frekuensi 2 kali per hari. Kesimpulan: Hasil studi kasus ini merekomendasikan mirror therapy dapat dijadikan sebagai terapi yang efektif dan efisien bagi klien stroke dengan hemiparesis yang dapat diterapkan oleh perawat
HUBUNGAN TEKNIK PEMANASAN TERHADAP RESIKO LOW BACK PAIN PADA PEMAIN BASKET DI UNIVERSITAS SARI MULIA BANJARMASIN
Authors: Priwijaya Ardianto , Mahmudah Rifa’atul , Basit Mohammad , Manto Onieqie Ayu Dhea
Published: November 2023

Pendahuluan: Nyeri punggung bawah (LBP) adalah rasa nyeri yang dirasakan pada punggung bawah yang sumbernya adalah tulang punggung daerah spinal (Punggung bawah), otot, saraf atau struktur lainnya sekitar daerah tersebut. Berdasarkan dari laporan dari Global Burden Of Disease mengatakan bahwa 1 dari 10 orang diseluruh dunia mengalami keluhan LBP. Menurut WHO, data menunjukan bahwa 33% penduduk di Negara berkembang mengalami nyeri punggung. prevalensi penyakit pada muskuloskeletal di Kalimantan Selatan berada pada urutan ke 4. Pemanasan merupakan aspek terpenting dalam sesi latihan, Para pemain perlu melakukannya dengan benar, untuk memaksimaslkan performan dan memperkecil resiko cedera, Adapun faktor lain yang mempengaruhi resiko Low Back Pain seperti faktor usia,  jenis kelamin dan IMT. Tujuan: Penelitian ini bertujuan untuk mengetahui, mengidentifikasi dan menganalisis hubungan teknik Pemanasan terhadap Resiko low back pain pada pemain basket di Universitas Sari Mulia Banjarmasin. Metode: Rancangan dalam penelitian yaitu menggunakan Kuantitatif Deskriptif dengan pendekatan cross sectional dan pengambilan sampel menggunakan total sampling dengan jumlah 50 responden. Hasil: Pada penelitian ini terdapat  (36%) yang menguasai teknik pemanasan dengan tingkat resiko low back pain rendah. Sedangkan (28%) tidak menguasai teknik pemanasan dengan tingkat resiko Low Back Pain tinggi . Salah satu hasil uji sampel memberikan nilai p?0. 0,05 artinya Ho ditolak dan Ha diterima sehingga  terdapat hubungan antara teknik pemanasan terhadap resiko low back pain pada pemain basket. Simpulan: Hasil dari penelitian menyatakan ada hubungan Teknik pemanasan terhadap resiko Low Back Pain pada pemain basket di Universitas Sari Mulia Banjarmasin
DETEKSI DINI RISIKO HIPERTENSI DAN EDUKASI KESEHATAN PADA MAHASISWA PROGRAM STUDI D-III KEPERAWATAN STIKES PEMKAB JOMBANG
Authors: Dwiningtyas Mumpuni
Published: November 2023

Pendahuluan: Penelitian menunjukkan anak-anak atau remaja memiliki potensi hipertensi esensial di masa yang akan datang. Jenis kelamin, genetik (faktor keluarga), obesitas, konsumsi garam, gaya hidup dan kebiasaan, aktivitas fisik, merokok, dan konsumsi alkohol dapat meningkatkan risiko hipertensi pada remaja. Tujuan: Penelitian ini bertujuan untuk mengetahui faktor resiko terjadinya hipertensi pada mahasiswa D3 Keperawatan STIKES Pemkab Jombang. Metode: Penelitian ini merupakan penelitian deskriptif kuantitatif dengan populasi dan sampel yang merupakan seluruh mahasiswa D3 Keperawatan STIKES Pemkab Jombang sebanyak 61 responden. Data dianalisis menggunakan uji statistik Chi Square. Hasil: Hasil analisis univariat didapatkan sebagian besar mahasiswa memiliki tekanan darah normal sebanyak 95,1%, berusia lebih dari 20 tahun sebanyak 75,4%, berjenis kelamin perempuan sebanyak 80,3%, tidak memiliki anggota keluarga hipertensi sebanyak 77,0%, memiliki indeks masssa tubuh (IMT) normal sebanyak 50,8%, dan menerapkan gaya hidup sehat 55,7%. Hasil analisis bivariat diketahui ada hubungan yang signifikan antara jenis kelamin (p value = 0,000), indeks massa tubuh (p value = 0,011), dan gaya hidup (p value = 0,046) dengan kenaikan tekanan darah. Kesimpulan: Ada hubungan yang signifikan antara jenis kelamin, indeks massa tubuh, dan gaya hidup dengan kenaikan tekanan darah pada mahasiswa D3 Keperawatan STIKES Pemkab Jombang.
APLIKASI KAEDAH FIQH DALAM PEMBENTUKAN PARAMETER KONTRAK PERNIAGAAN FRANCAIS DOBI LAYAN DIRI
Authors: Husain Mohd Huefiros Efizi , Abdul Jalil Abdullah Firdaus
Published: November 2023

Kontrak perniagaan francais adalah elemen penting menghubungkan keperluan di antara francaisor dan francaisi sepanjang kontrak berlangsung. Kedua-dua peranan tersebut perlu menyatakan persetujuan ke atas kontrak ditawarkan sebelum perniagaan mula beroperasi. Kontrak yang ditawarkan mengandungi terma khusus yang menfokuskan kepada bentuk operasi perniagaan dan matlamat yang mahu dicapai. Persetujuan mematuhi setiap terma dalam kontrak dituntut supaya kemungkiran dalam mendirikan kontrak dapat diatasi. Walaubagaimanapun, terdapat isu dalam kontrak francais yang belum menemui cara penyelesaian dan ia berlarutan kepada tempoh masa yang lama untuk diselesaikan. Ia memberi impak kepada prestasi operasi perniagaan dan hubungan kedua-dua peranan. Oleh itu, kajian ini meninjau langkah penyelesaian kepada isu tersebut berdasarkan kaedah fiqh tertentu dalam pembentukan parameter kontrak perniagaan francais dobi layan diri. Para fuqaha’ begitu meneliti menghasilkan kaedah fiqh menerusi kefahaman daripada sumber hukum utama Islam agar ia dijadikan rujukan dalam keperluan sejagat. Kajian ini menggunakan kaedah kualitatif untuk mencapai objektif kajian dengan melibatkan kaedah perpustakaan dan temubual bersama pakar. Hasil kajian mendapati kaedah fiqh yang disandarkan bersesuaian untuk dicadangkan dalam pembentukan parameter pelaksanaan kontrak dan menyelesaikan isu dalam perniagaan ini dengan segera. Kajian ini mencadangkan agar penghayatan kaedah fiqh dapat diperluaskan dalam kebanyakan kontrak perniagaan bagi memastikan matlamat operasi perniagaan dapat dicapai sepenuhnya.
Consequences of Thumb Sucking Habit among School Going Children: A Cross Sectional Study
Authors: Mannan Huda , Ahmed Anam , Nuruzzaman Khandakar , Hossain Suman , Tamij Nusrat
Published: November 2023

Background: Thumb-sucking, a non-nutritive sucking behavior, is a natural reflex seen in infants but can persist into childhood if not addressed leading to various dental and orofacial issues, including malocclusion, dental arch deformities, speech difficulties, and facial asymmetry. The aim of the study was to explore the consequences of thumb-sucking habits among the school going children. Methods: This cross-sectional study involved among purposively selected 124 school going children, aged between 5-8 years with their parents attended in the outpatient department of University Dental College at Moghbazar, Dhaka, Bangladesh. The data were obtained through a pretested structured questionnaire and checklist through face-to-face interview from parents regarding background characteristics, consequences of thumbs sucking and oral examination of children respectively.  Then, data were analyzed using statistical package for social sciences (SPSS) software version 27 for descriptive analysis (frequency, percentage) and inferential statistics (chi-square test or fisher’s exact test)  at 5% level of significance (P<0.05).  Results: The study revealed that 77.4% of children aged 5-6 years and about 41.9% of parents reported that their child had thumb sucking habit. The thumb sucking habit was found to be statistically significant with start of age thumb sucking( p= <0.001), duration of thumb sucking ( p= <0.001), pronunciation of word clearly( p= <0.001), proclination of maxillary anterior teeth (P=0.002), asymmetry of face (P=0.002) and seek for dental advice or treatment(p=0.002). Majority of children (21.8%) start thumb sucking at the age 6-7 years. Only 8.1% of the children didn’t pronounce words clearly whereas only 5.6%  had proclined maxillary anterior teeth, facial asymmetry and sought dental advice or treatment. Conclusion:  This study found a significant association of thumb-sucking habit among children with notable consequences. It highlights the importance of early intervention and parental education and  awareness regarding this habit's potential consequences on children's oral health and overall development.
Update Dent. Coll. j: 2023; 13(2): 19-22
Analisis Butir Soal Ujian Sekolah Mata Pelajaran Ilmu Pengetahuan Sosial Kelas VI SDN Kota Bengkulu Tahun Pelajaran 2019/2020
Authors: Yusnia Yusnia , Badeni Badeni , Djuwita Puspa
Published: November 2023

This study aims to describe the proportion of the cognitive level, affective level, logically and empirically the question items on the School Examination in Social Sciences subjects for the sixth grade students of SDN Kota Bengkulu for the 2019/2020 academic year. This type of research is descriptive research. The subjects in this study were students of class VI SDN 53, SDN 18, and SDN 29 Bengkulu City. The object of this research is the suitability of the questions and answer keys, answers to the school exam. The research instrument used is in the form of a document in the form of a cognitive level report analysis sheet, and an affective level report analysis sheet, questions and answer keys, answers to school exams. The data analysis uses the population level cognitive affective level on the items analyzed, the percentage is calculated, as well as descriptive analysis of material aspects, construction, and language by asking for validation from analysis experts/ experts using Aiken V. The results show that: 1) The proportion of cognitive levels, including levels understand (C2) as many as 14 items (35%), the level of implementing (C3) is 9 items (22.50%), the level of analysis (C4) is 15 items (37.50%), and the level of understanding (C5) as many as 2 items (5%); 2) The proportion of the affective level, including the response level (A2) as many as 1 item (2.5%), the respect level (A3) as many as 3 items (7.5%) and the organizing level (A4) as many as 3 questions (7, 5%); 3) the quality of the items logically based on the results of the validation of material aspects, construction, and language. 40 multiple choice test items show the information displayed in the range> 0.8 with the category "very valid" in accordance with the principles of assessment, namely fair, open, comprehensive and continuous, systematic, reference criteria, and accountable; and 4) The quality of the items empirically, the validity results show that 39 items are valid and 1 item is invalid, the reliability test results are 0.735 so it can be interpreted that these items have a high level of reliability, the results of the difficulty level test show that 15 items Medium category questions (37.5%) and 24 items in the easy category (60%), the results of the distinguishing power test showed that 5 items were in the good category (12.5%), 34 items were in the sufficient category (85%) in accordance with the principle Output, namely valid, objective, open, systematic, and based on criteria. Thus it can be denied that the quality of the School Examination items in the Social Sciences subject grade VI SDN Kota Bengkulu for the 2019/2020 academic year is good in terms of the statement of cognitive level, affective level, quality based on logical and empirical tests.
Keefektifan Metode MFEP, MAUT, dan VIKOR Dalam Aplikasi Sistem Pendukung Keputusan Mahasiswa Berprestasi (Studi Kasus: Poltekkes Kemenkes Bengkulu)
Authors: Andreswari Desi , Susilo Boko , Vista Novia Bella
Published: November 2023

Sebuah perguruan tinggi tentu memiliki banyak permasalahan yang perlu diselesaikan dengan sebuah tindakan pengambilan keputusan. Salah satunya yaitu proses pemilihan mahasiswa berprestasi. Oleh karena itu, dibutuhkan sebuah sistem pendukung keputusan dalam pemilihan mahasiswa berprestasi. Tujuan penelitian ini adalah (i) merancang dan membangun sistem pendukung keputusan pemilihan mahasiswa berprestasi yang mampu memberikan rekomendasi yang akurat. (ii) mengetahui tingkat keefektifan dari  metode MFEP, MAUT, dan VIKOR dalam melakukan pemilihan mahasiswa berprestasi. Metode yang digunakan dalam penelitian ini, adalah metode MFEP, MAUT, dan VIKOR. Hasil penelitian menunjukkan keefektifan metode MFEP = 60%, MAUT = 80%, dan VIKOR = 100%. Dari ketiga metode tersebut, metode VIKOR adalah yang paling efektif digunakan dalam menentukan mahasiswa berprestasi.Kata Kunci : Sistem Pendukung Keputusan, Mahasiswa Berprestasi, Metode MFEP, Metode MAUT, Metode VIKOR.
PENERAPAN METODE VARIABLE-CENTERED INTELLIGENT RULE SYSTEM (VCIRS) DAN CERTAINTY FACTOR PADA SISTEM PAKAR IDENTIFIKASI HAMA TANAMAN SORGUM
Authors: Andreswari Desi , Ginting Sempurna , Nurul Masyita Febridila
Published: November 2023

Dalam rangka kurangi ketergantungan terhadap bahan pangan impor maka butuh dikembangkan bahan pangan lokal yaitu sorgum yang toleran terhadap tanah yang kurang subur mengingat ketersediaan lahan sawah yang terbatas sehingga dapat dijadikan sebagai tanaman diversifikasi pangan pokok beras serta mengurangi konsumsi terigu. Akan tetapi dalam proses budidaya sorgum terdapat hambatan yaitu adanya serangan hama yang dapat menghabiskan hasil tanam. Perihal yang kerap terjadi, banyak kerugian yang disebabkan oleh terdapatnya hama tumbuhan yang terlambat buat diidentifikasi serta telah menggapai tahap yang parah serta menimbulkan terbentuknya gagal panen. Untuk itu, diperlukan sistem yang dapat mengidentifikasi hama tanaman sorgum hingga memberikan solusi penanganannya. Salah satunya sistem yang menerapkan metode Variable-Centered Intelligent Rule System dan Certainty Factor berbasis web. Sehingga, sistem dapat menjembatani petani untuk menyelesaikan permasalahannya tanpa harus bertemu langsung dengan ahlinya. Berdasarkan hasil pengujian dari 26 data uji pada hama tanaman sorgum, sistem memiliki nilai akurasi sebesar 96% sehingga dapat disimpulkan sistem dapat mengidentifikasi hama tanaman sorgum dengan baik.
IMPLEMENTASI K-MEANS CLUSTERING DAN COSINE SIMILARITY PADA CASE BASE REASONING UNTUK DIAGNOSA PENYAKIT SAPI (STUDI KASUS: PENYAKIT SAPI DI KOTA BENGKULU)
Authors: Barly Zahira Salsabila , Coastera Funny Farady , Yusa Mochammad
Published: November 2023

Dari berbagai macam jenis hewan ternak yang paling banyak dipelihara atau diternakkan oleh peternak adalah sapi. Sebagai negara yang memiliki iklim tropis, berbagai macam keadaan cuaca dapat menyebabkan kesehatan sapi perlu diperhatikan karena dapat menimbulkan penyakit. Dengan dilakukan penelitian ini dapat mempermudah peternak sapi dalam mendiagnosa penyakit pada sapi dengan gejala-gejala yang diderita menggunakan sistem yang mengimplementasikan algoritma K-Means Clustering dan Cosine Similarity pada Case Base Reasoning untuk diagnosa penyakit sapi. Sistem pakar yang dirancang dapat mendeteksi 7 penyakit dengan total 34 gejala serta memberikan solusinya. Algoritma K-Means Clustering digunakan untuk mengelompokkan basis pengetahuan. Terdapat 3 kelompok yang ditentukan menggunakan metode elbow. Cosine similarity digunakan untuk mendapatkan nilai kemiripan kasus dengan kasus lama untuk menentukan penyakit yang diderita oleh sapi. Proses pengujian fungsionalitas sistem pakar ini berjalan dengan baik menggunakan black box testing dan menghasilkan keberhasilan fungsional sebesar 100%. Penelitian ini dilakukan dengan menguji 40 data uji dan menghasilkan tingkat akurasi sebesar 92,5%.
REAL TIME DETECTION OF CHICKEN EGG QUANTITY
Authors: Sandy Cut Lika Mestika , Husna Asmaul , Rizal Reyhan Achmad , Muhathir Muhathir
Published: November 2023

A common problem currently being faced in the chicken egg production home industry is difficulty in counting the number of eggs. Currently, calculating the number of eggs is still done manually, which is less than optimal and prone to errors, so many entrepreneurs often experience losses. The manual system currently used also has the potential for this to happen. The use of technology on an MSME scale among laying hen breeders has not been widely adopted, this is due to limited access and understanding of technology. One alternative solution to deal with this problem is to build a real-time computerized system. The system that will currently be built in this research uses GLCM feature extraction and the SVM classification method. This system will detect egg production via CCTV cameras and will be stored in a database to be displayed on the website. The advantage of this system is that egg entrepreneurs can monitor chicken egg yields in real time. The results of trials that have been carried out using GLCM feature extraction and the SVM classification method in calculating the number of eggs using the SVM method with a polynomial kernel are highly recommended for use in this research because it can achieve 95% accuracy.
Cytosolic free Ca2+ concentration in canine aortic endothelial cells lining the polyester arterial prosthesis.
Authors: Ondruš P , Alberty R , Pothier P , Echavé V , Poisson J , Bkaily G
Published: November 2023

A rise in baseline cytosolic free Ca2+ in canine vascular endothelial-like cells (VEC) lining the luminal surface of the polyester arterial prosthesis is described. In one, three and six month implantation experiments we employed six adult mongrel dogs, polyester arterial prostheses Arteknit Ra K, fluorescent Ca2+ indicator Fura-2 and digital imaging microscopy to study cytosolic free Ca2+ in cultured VEC. The electron microscopy scanning of the luminal surface in different regions of the graft were also performed. A rise in cytosolic free Ca2+ in the VEC lining the luminal surface of the prosthesis is probably the result of the immunologic reaction and mechanical stress which stimulate the proliferation activity of the endothelial cells. It seems that the baseline cytosolic free Ca2+ reflects the course of the endothelization process on the polyester arterial prosthesis.
Requirements and methods of protection of copyright and related rights: correlation of concepts
Authors: Shtefan Olena
Published: November 2023

This article is dedicated to distinguishing the concepts of «requirement» and «methods of protection». The need to distinguish between these concepts is related to the provision of civil procedural legislation, which contains various procedural consequences regarding the requirements and methods of protection that the plaintiff, through the court, applies to the defendant. It is the plaintiff who must exercise his right when applying to the court to determine his demands against the defendant and choose the way to protect his violated, unrecognized or disputed rights, freedoms or interests. The court has the duty to consider and decide the case exclusively within the limits of the stated requirements. At the same time, under certaincircumstances, the court may apply the method of protection that it considers effective, taking into account the specific circumstances of the case. Effective legal protection of copyright and/or related rights depends on the forms, methods and means ofprotection chosen by the subject of law. It should be taken into account that the requirements are specified in the methods of protection, which in turn are specified in the means of protection — sanctions. At the same time, «requirements», «methods of protection» and «means of protection» are different legal concepts, although they are mutually dependent.

The existing legal limitation of the court, led to the emergence of such concepts as «improper method of protection» and «ineffective method of protection» in the civil procedural doctrine and law enforcement practice of the court. If the plaintiff chooses an inappropriate method of defense when applying to the court, this becomes the basis for refusing to satisfy the claims, and if the plaintiff chooses an ineffective method of protecting the violated right, it leads to the refusal to satisfy the claims.

The conducted study of the provisions of material and procedural legislation allows us to talk about the need to make changes to the material legislation in order to clearly regulate the requirements, methods of protection and sanctions for violation of copyrightand/or related rights. In turn, such changes will make it possible to implement the general legal principle of legal certainty, which is a component of the principle ofthe rule of law.
The TRK-fused gene negatively regulates interferon signaling by inhibiting TBK1 phosphorylation during PPMV-1 infection
Authors: Tian Ye , Xue Ruixue , Yu Cuilian , Liu Liping , Chen Shumin , Lv Junfeng
Published: November 2023

TRK-fused gene (TFG, tropomyosin-receptor kinase fused gene) is known to negatively regulate the retinoic acid inducible gene (RIG)-I-like receptor (RLR)-mediated interferon (IFN)-I pathway in human cells, thereby participating in the paramyxovirus infection process. We showed that pigeon paramyxovirus type 1 (PPMV-1) infection significantly upregulates TFG expression in infected cells at an early stage. We speculated that PPMV-1 would inhibit IFN activation by upregulating a negative regulator of the IFN pathway. This hypothesis was proved when TFG protein expression was knocked down by RNAi and the replication level of PPMV-1 virus decreased, which indicated that TFG upregulation in the early infection stage benefit virus replication. We next used the IFN-β promoter reporter system to evaluate the role of the TFG in the IFN pathway. The results showed that the TFG inhibited the IFN-β expression stimulated by RIG-I, MAVS (mitochondrial antiviral signaling protein) and TANK-binding kinase 1 (TBK1), but did not inhibit IFN-β activated by the interferon regulatory transcription factor 3 (IRF3), indicating that TFG may affect the function of TBK1, which play an important role in phosphorylation of the IRF3. Further experiments showed that the TFG inhibited the phosphorylation of TBK1, resulting in IRF3 being unable to be phosphorylated. Subsequent experiments on IFN pathway activation confirmed that the IRF3 phosphorylation level was significantly downregulated after overexpression of TFG, while the IFN-β promoter reporting experiment showed that TFG did not directly inhibit the IFN response activated by IRF3. This confirmed that TFG protein negatively regulates the IFN-β pathway by inhibiting TBK1 phosphorylation.
Surveillance of SARS-CoV-2 immunogenicity: loss of immunodominant HLA-A*02-restricted epitopes that activate CD8+ T cells
Authors: Lopes-Ribeiro Ágata , Oliveira Patrícia de Melo , Retes Henrique Morais , Barbosa-Stancioli Edel Figueiredo , da Fonseca Flávio Guimarães , Tsuji Moriya , Coelho-dos-Reis Jordana Grazziela Alves
Published: November 2023

Introduction and methods

In this present work, coronavirus subfamilies and SARS-CoV-2 Variants of Concern (VOCs) were investigated for the presence of MHC-I immunodominant viral peptides using in silico and in vitro tools.

Results

In our results, HLA-A*02 haplotype showed the highest number of immunodominant epitopes but with the lowest combined prediction score. Furthermore, a decrease in combined prediction score was observed for HLA-A*02-restricted epitopes when the original strain was compared to the VOCs, indicating that the mutations on the VOCs are promoting escape from HLA-A2-mediated antigen presentation, which characterizes a immune evasion process. Additionally, epitope signature analysis revealed major immunogenic peptide loss for structural (S) and non-structural (ORF8) proteins of VOCs in comparison to the Wuhan sequence.

Discussion

These results may indicate that the antiviral CD8+ T-cell responses generated by original strains could not be sufficient for clearance of variants in either newly or reinfection with SARS-CoV-2. In contrast, N epitopes remain the most conserved and reactive peptides across SARS-CoV-2 VOCs. Overall, our data could contribute to the rational design and development of new vaccinal platforms to induce a broad cellular CD8+ T cell antiviral response, aiming at controlling viral transmission of future SARS-CoV-2 variants.
Estimation of life expectancy and healthcare cost in rheumatoid arthritis patients with and without depression: a population-based retrospective cohort study
Authors: Chiu Ying-Ming , Lan Joung-Liang , Huang Wei-Lieh , Wu Chi-Shin
Published: November 2023

Purpose

This study aimed to estimate the lifetime healthcare costs and loss of life expectancy (loss-of-LE) among patients with incident rheumatoid arthritis (RA) with and without depression.

Methods

This 18 years longitudinal cohort study used data from Taiwan’s National Health Insurance Research Database. In total, 43,311 patients with RA were included. Among them, 1,663 patients had depressive disorders in the year preceding the RA diagnosis. The survival function for patients with RA with or without depression was estimated and extrapolated over a lifetime using the rolling extrapolation algorithm. The loss-of-LE was calculated by comparing the sex, age, and calendar year-matched referents from vital statistics. The average monthly cost was calculated as the sum of the monthly costs for all patients divided by the number of surviving patients. Lifetime healthcare costs were estimated by multiplying the monthly average cost by the monthly survival probability.

Results

The loss-of-LE for RA patients with and without depression was 5.60 years and 4.76 years, respectively. The lifetime costs of RA patients with and without depression were USD$ 90,346 and USD$ 92,239, respectively. However, the annual healthcare costs were USD$ 4,123 for RA patients with depression and USD$ 3,812 for RA patients without depression. Regardless of sex or age, RA patients with depression had higher annual healthcare costs than those without depression.

Conclusion

Patients with RA and depression have a high loss-of-LE and high annual healthcare costs. Whether treating depression prolongs life expectancy and reduces healthcare costs warrants further investigation.
Comparative analysis of the intestinal microbiome in Rattus norvegicus from different geographies
Authors: Shah Taif , Hou Yutong , Jiang Jinyong , Shah Zahir , Wang Yuhan , Li Qian , Xu Xiang , Wang Yixuan , Wang Binghui , Xia Xueshan
Published: November 2023

Rat species Rattus norvegicus, also known as the brown street rat, is the most abundant mammal after humans in urban areas, where they co-exist with humans and domestic animals. The reservoir role of R. norvegicus of zoonotic pathogens in cities among rodent-borne diseases that could endanger the lives of humans and other mammals. Therefore, understanding the normal microbiome of R. norvegicus is crucial for understanding and preventing zoonotic pathogen transmission to humans and animals. We investigated the intestinal microbiome of free-living R. norvegicus collected from the Ruili, Nujiang, and Lianhe regions of Yunnan, China, using 16S rRNA gene sequence analysis. Proteobacteria, followed by Firmicutes, and Bacteroidetes were abundant in the intestines of R. norvegicus; however, bacterial compositions varied significantly between samples from different locations. Following a similar trend, Gammaproteobacteria, Bacilli, and Clostridia were among the top bacterial classes in most intestinal samples. The situation differed slightly for the Lianhe and Nujiang samples, although Phyla Bacteroidota and Spirochaetota were most prevalent. The Alpha diversity, Chao1, and Simpson indexes revealed microbial richness among the R. norvegicus samples. A slight variation was observed among the samples collected from Ruili, Nujiang, and Lianhe. At species levels, several opportunistic and zoonotic bacterial pathogens, including Lactococcus garvieae, Uruburuella suis, Bartonella australis, Clostridium perfringens, Streptococcus azizii, Vibrio vulnificus, etc., were revealed in the R. norvegicus intestines, implying the need for a regular survey to monitor and control rodent populations. In conclusion, we explored diverse microbial communities in R. norvegicus intestines captured from different regions. Further, we identified several opportunistic and potential bacterial pathogens, which still need to be tested for their underlying pathogenesis. The findings of our current study should be considered a warning to the health authorities to implement rat control and surveillance strategies globally.
Cish knockout mice exhibit similar outcomes to malaria infection despite altered hematopoietic responses
Authors: Lakkavaram Asha L. , Maymand Saeed , Naser Wasan , Ward Alister C. , de Koning-Ward Tania F.
Published: November 2023

The Cytokine-inducible Src homology 2 domain-containing (CISH) protein is a negative feedback regulator induced by cytokines that play key roles in immunity and erythropoiesis. Single nucleotide polymorphisms (SNPs) in the human CISH gene have been associated with increased susceptibility to severe malaria disease. To directly assess how CISH might influence outcomes in the BALB/c model of malaria anemia, CISH knockout (Cish−/−) mice on this background were infected with Plasmodium berghei and their hematopoietic responses, cytokine production and ability to succumb to severe malaria disease evaluated. Despite basal erythrocytic disruption, upon P. berghei infection, the Cish −/− mice were better able to maintain peripheral blood cell counts, hemoglobin levels and a steady-state pattern of erythroid differentiation compared to wild-type (Cish+/+) mice. Ablation of CISH, however, did not influence the outcome of acute malaria infections in either the BALB/c model or the alternative C57BL/6 model of experimental cerebral malaria, with the kinetics of infection, parasite load, weight loss and cytokine responses being similar between Cish+/+ and Cish−/− mice, and both genotypes succumbed to experimental cerebral malaria within a comparable timeframe.
Feasibility and safety study of wearable cyborg Hybrid Assistive Limb for pediatric patients with cerebral palsy and spinal cord disorders
Authors: Takahashi Kazushi , Mizukami Masafumi , Watanabe Hiroki , Kuroda Mayumi Matsuda , Shimizu Yukiyo , Nakajima Takashi , Mutsuzaki Hirotaka , Kamada Hiroshi , Tokeji Kayo , Hada Yasushi , Koseki Kazunori , Yoshikawa Kenichi , Nakayama Tomohiro , Iwasaki Nobuaki , Kawamoto Hiroaki , Sankai Yoshiyuki , Yamazaki Masashi , Matsumura Akira , Marushima Aiki
Published: November 2023

Introduction

The wearable cyborg Hybrid Assistive Limb (HAL) is the world’s first cyborg-type wearable robotic device, and it assists the user’s voluntary movements and facilitates muscle activities. However, since the minimum height required for using the HAL is 150 cm, a smaller HAL (2S size) has been newly developed for pediatric use. This study aimed to (1) examine the feasibility and safety of a protocol for treatments with HAL (2S size) in pediatric patients and (2) explore the optimal method for assessing the efficacy of HAL.

Methods

This clinical study included seven pediatric patients with postural and motor function disorders, who received 8–12 sessions of smaller HAL (2S size) treatment. The primary outcome was the Gross Motor Function Measure-88 (GMFM-88). The secondary outcomes were GMFM-66, 10-m walk test, 2- and 6-min walking distances, Canadian Occupational Performance Measure (COPM), a post-treatment questionnaire, adverse events, and device failures. Statistical analyses were performed using the paired samples t-test or Wilcoxon signed-rank test.

Results

All participants completed the study protocol with no serious adverse events. GMFM-88 improved from 65.51 ± 21.97 to 66.72 ± 22.28 (p = 0.07). The improvements in the secondary outcomes were as follows: GMFM-66, 53.63 ± 11.94 to 54.96 ± 12.31, p = 0.04; step length, 0.32 ± 0.16 to 0.34 ± 0.16, p = 0.25; 2-MWD, 59.1 ± 57.0 to 62.8 ± 63.3, p = 0.54; COPM performance score, 3.7 ± 2.0 to 5.3 ± 1.9, p = 0.06; COPM satisfaction score, 3.3 ± 2.1 to 5.1 ± 2.1, p = 0.04.

Discussion

In this exploratory study, we applied a new size of wearable cyborg HAL (2S size), to children with central nervous system disorders. We evaluated its safety, feasibility, and identified an optimal assessment method for multiple treatments. All participants completed the protocol with no serious adverse events. This study suggested that the GMFM would be an optimal assessment tool for validation trials of HAL (2S size) treatment in pediatric patients with posture and motor function disorders.
Case report: Deep molecular remissions post two separate CD19-targeted chimeric antigen receptor T-cell therapies do not prevent disease from relapsing in Philadelphia chromosome-positive acute lymphoblastic leukemia
Authors: Tang Yu , Fei Xiaoming , Yu Xianqiu , Cao Jiang , Wang Lixia , Lei Fang
Published: November 2023

Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL) is an aggressive B-cell malignancy. The management of a relapsed Ph+ ALL patient is challenging. Currently, either allogeneic stem cell transplant (allo-SCT) or CD19-targeted chimeric antigen receptor T-cell (CAR T-cell) are usually employed as salvage modalities for a relapsed patient. However, there are few reports concerning cases that had both allo-SCT and multiple CAR T-cell therapies, and the optimal management of such patients is unclear. Here, we report a relapsed Ph+ ALL male who was first salvaged with autologous CAR T-cell therapy, followed by allo-SCT. Unfortunately, he had a second relapse even with complete molecular remission (CMR) response after the first CAR T and allo-SCT. This patient was then successfully salvaged by a second CAR T-cell product that is donor-derived. However, even with a CMR response once again following the second CAR T-cell therapy and prophylactic donor lymphocyte infusion, he experienced a molecular relapse; ponatinib was employed as the subsequent salvage treatment. He achieved a CMR response following ponatinib and was still in remission at the last follow-up. No ABL kinase mutation was detected during the whole course of the disease. This case indicated that a repeated CD19-targeted CAR T-cell treatment is feasible and may be effective in a relapsed Ph+ ALL patient that had previous CAR T-cell and allo-SCT, even though both CAR T-cell have the same construction. However, even with a deep response after each CAR T-cell therapy and allo-SCT, there is still a very small amount of undetectable leukemic cells. The optimal management of Ph+ ALL patients who have a deep response after a second CAR T-cell therapy deserves further exploration.
Metabolic bulk volume from FDG PET as an independent predictor of progression-free survival in follicular lymphoma
Authors: So Heejune , Lee Hyunjong , Hyun Seung Hyup , Cho Young Seok , Moon Seung Hwan , Choi Joon Young , Lee Kyung-Han
Published: November 2023

Background

Total metabolic tumor volume (TMTV) in 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) predicts patient outcome in follicular lymphoma (FL); however, it requires laborious segmentation of all lesions. We investigated the prognostic value of the metabolic bulk volume (MBV) obtained from the single largest lesion.

Methods

Pretreatment FDG PET/computed tomography (CT) scans of 201 patients were analyzed for TMTV and MBV using a 41% maximum standardized uptake value (SUVmax) threshold.

Results

During a median follow-up of 3.2 years, 54 events, including 14 deaths, occurred. Optimal cut-offs were 121.1 cm3 for TMTV and 24.8 cm3 for MBV. Univariable predictors of progression-free survival (PFS) included a high Follicular Lymphoma International Prognostic Index 2 (FLIPI2) score, TMTV, and MBV. In the multivariable analysis, high TMTV and MBV were independent predictors of worse PFS (P =0.015 and 0.033). Furthermore, in a sub-group with FLIP2 scores of 0–2 (n = 132), high MBV could identify patients with worse PFS (P = 0.007). 

Conclusion

Readily measurable MBV is useful for stratifying risk in FL patients.
Health status of the population in Naqu, Tibet and its latent class analysis: a cross-sectional survey
Authors: Cui Jiaxue , Nima Ouzhu , Zhaxi Duoji , Jin Chenxin , Wang Ruiqi , Diao Yizhuo , Chen Yongxing , Xu Xiaoguang , Li Xiaofeng
Published: November 2023

Background

Through a survey and analysis of the population’s present state of health, it is possible to give data support for improving the health status of inhabitants in Naqu, Tibet. Additionally, it is possible to provide specific recommendations for the development of medical and healthcare facilities in Tibet.

Methods

The health scores of the participants were based on their responses to the four main sections of the questionnaire: dietary habits, living habits, health knowledge, and clinical disease history, and the variability of health status among groups with different characteristics was analyzed based on the scores. The four major sections were used to create classes of participants using latent class analysis (LCA). Using logistic regression, the factors influencing the classification of latent classes of health status were investigated.

Results

A total of 995 residents from 10 counties in Naqu were selected as the study subjects. And their demographic characteristics were described. The mean health score of residents after standardization was 81.59 ± 4.68. With the exception of gender, health scores differed between groups by age, education level, different occupations, marital status, and monthly income. The health status in Naqu, Tibet, was divided into two groups (entropy = 0.29, BLRT = 0.001, LMRT = 0.001) defined as the “good health group” and the “general health group.” A monthly income of more than ¥5000 adverse to good health in Naqu, Tibet.

Discussion

Single, well-educated young adults in Naqu, Tibet, have outstanding health. The vast majority of people in Tibet’s Naqu region were in good health. Furthermore, the population’s latent health status was divided into two classes, each with good dietary and living habits choices, low health knowledge, and a history of several clinical diseases. Univariate and multivariate logistic regression analysis showed that monthly income more than ¥5000 was an independent risk factor for poor health status.