bluuebunny/crossref_metadata_2025 huggingface dataset:
Learning Innovation Content Creators Social Media-Based Qualitative Analysis to Improve Motivation and Learning Outcomes of Professional Teacher Candidates: A Systematic Literature Review
Authors: Widarti Hayuni Retno , Anggraini Tria , Rokhim Deni Ainur , Syafruddin Afis Baghiz
Published: January 2023

Students need motivation in order to increase their interest and focus of students. One way to increase students' learning motivation is by presenting interesting learning media for students. Social media is an audio-visual platform that steals the attention of many people in various groups, especially children to teenagers. The method applied in this research is the systematic literature review (SLR) method. The SLR method is used to identify, review, evaluate and interpret all available studies in a subject area of interest to a phenomenon involving a particular related research question. In the Literature Review Study that has been described, it can be concluded that research on Creator Content in Social Media-Based Chemistry Learning Media can be carried out with various considerations of research results similar to the Multi-representation approach which can increase student motivation and learning outcomes.
Recent Studies of Corrosion - Fatigue Crack Growth on the 7081-T73511 Aluminium Alloy
Authors: Moreto Jeferson , Bose Filho Waldek Wladimir
Published: January 2023

This work aims to evaluate the effect of localized corrosion on the fatigue crack growth (FCG) resistance of the 7081-T73511 aluminium alloy. The understanding of this complex combined process was explained by the dissolution of adjacent 7081-T73511 aluminium matrix promoted by the Al7Cu2Fe second-phase particle and the crack tip interaction time with the aggressive medium. Fracture surfaces produced in air and in sea water fog at the testing conditions applied here, basically present the same appearance, with a transgranular, cleavage-like cracking mode for 8 <DK< 30 values.
PENGARUH PERSEPSI RISIKO, PENCARIAN DAN PEMROSESAN INFORMASI RISIKO, SERTA PERILAKU KOMUNIKASI TERHADAP INTENSI PERILAKU
Authors: Triana Nunik , Hendriyani
Published: January 2023

Media sosial kini telah menjadi alat potensial untuk kampanye kesehatan. Beragam penelitian terkait pengaruh media sosial pada intensi perilaku dalam kampanye juga telah banyak dilakukan, namun masih sedikit yang melibatkan perilaku komunikasi. Menstimulasi perilaku pencarian informasi merupakan hasil penting dari kampanye kesehatan karena perilaku ini yang cenderung tetap efektif setelah kampanye kesehatan berakhir. Terkait dengan hal tersebut, penelitian ini meneliti apakah media sosial berperan dalam kampanye kesehatan yang bertujuan pada intensi perilaku dengan mediasi perilaku komunikasi. Penelitian ini memadukan pendekatan psikologi dan komunikasi dalam memprediksi intensi perilaku pencegahan anak stunting (kerdil). Fokus terhadap stunting dilakukan karena hal ini menjadi masalah gizi utama di Indonesia. Peneliti menggunakan adaptasi model penelitian yang memadukan Theory of Planned Behaviour, Risk Information Seeking and Processing model, Risk Perception Attitude Framework, serta Situational Theory of Problem Solving. Penelitian dilakukan secara kuantitatif. Pengambilan data dilaksanakan dengan survey online pada wanita yang menjadi pengikut akun kampanye pencegahan stunting milik Kementerian Komunikasi dan Informatika. Hasil penelitian menemukan bahwa intensi perilaku pencegahan stunting paling dapat diprediksi dengan perilaku transmisi informasi (information transmission). Dalam hal ini transmisi informasi mampu memediasi hubungan antara kepercayaan pada saluran yang relevan (relevant channel belief) dengan intensi perilaku pencegahan stunting.
Peluang Faith-based Marketing Komunikasi dalam Promosi Produk Cryptocurrency di Indonesia
Authors: Ekaputri Sarah Derma , Karolina Cut Meutia
Published: January 2023

Berbagai pendapat pro dan kontra mengenai halal atau haram crypto currency menjadi salah satu pembicaraan yang banyak dibahas masyarakat siber.  Namun, di tengah keributan tersebut, sebuah produk crypto currency melakukan promosi produknya yang tak luput dari penggunaan simbol-simbol agama (Faith based Marketing).  Penelitian ini bertujuan untuk mengetahui bagaimana investasi crypto yang dipromosikan dengan pendekatan Faith based Marketing dipandang oleh masyarakat siber di Indonesia dengan menggunakan studi kualitatif netnografi. Teori dan konsep yang digunakan pada penelitian ini meliputi Faith-based Marketing (FbM), teori participatory culture, dan kredibilitas sumber.  Hasil penelitian menunjukkan bahwa kategori respons masyarakat siber mengenai topik dengan pendekatan FbM ini terdiri dari empat kategori, yaitu (1) Ketidakpercayaan pada praktik faith-based Marketing; (2) Perdebatan Halal/Haram Produk; (3) Kredibilitas komunikator dan produk; dan (4) ketidakpedulian. Temuan ini dapat menjadi pertimbangan dalam perencanaan pemasaran produk, terutama dengan pendekatan FbM.  Temuan unik pada penelitian ini berkaitan dengan FbM yang pada kenyataannya belum tentu mendapat respon baik pada setiap praktiknya. Penelitian lanjutan yang disarankan yaitu mengembangkan topik penelitian yang sama dengan menggunakan strategi lainnya seperti studi kasus, fenomenologi dan dapat pula diuji secara kuantitatif untuk mengukur efektivitas pemasaran cryptocurrency dengan pendekatan FbM.
PENINGKATAN KEPUASAN PELANGGAN MELALUI PERBAIKAN KUALITAS INFORMASI DI KOMPAS.COM
Authors: Zulvia Pepi , Haryanto Niko Dwi , Buana Anas Alrasyid Putrawidya
Published: January 2023

Kompas.com menjadi situs berita terpopuler di Indonesia dan menggantungkan sebagian besar pendapatannya melalui iklan–iklan yang masuk, tentu saja hal ini didasarkan pada tingkat kepuasan pelanggan pada kualitas informasi yang diberikan. Penelitian ini bertujuan dalam mengukur kepuasan pelanggan dengan ACSI, memetakan atribut kualitas informasi dengan IPA dan menentukan prioritas perbaikan dengan PGCV. Sampel yang didapatkan pada penelitian ini sebesar 58 orang pelanggan Kompas.com dengan teknik convenience sampling. Penelitian ini menggunakan data primer yang didapatkan melalui penyebaran 3 kuesioner (kepuasan, harapan dan kinerja) terhadap responden. Teknik analisis yang digunakan terdiri dari CSI, IPA dan PGCV. Hasil penelitian ini menunjukkan bahwa dengan ACSI didapatkan tingkat kepuasan sebesar 80,04%, melalui IPA didapatkan pada kuadran 1 terdapat 7 atribut, kuadran 2 terdapat 4 atribut, kuadran 3 terdapat 2 atribut dan kaudran 4 terdapat 5 atribut, dan melalui PGCV didapatkan 5 prioritas perbaikan yang terdiri dari tingkat ketersediaan informasi yang dimuat, penyajian informasi yang mudah dipahami maknanya oleh penerima, keutuhan isi informasi yang dimuat, konsistensi penyajian informasi yang teratur dan tidak menyimpang dan informasi yang disampaikan terbebas dari kesalahan dan mampu memberikan bukti. Simpulan penelitian ini yaitu pihak manajemen Kompas.com perlu melakukan adnaya peningkatan kepuasan melalui perbaikan kualitas informasi.
ANALISIS STRUKTUR JARINGAN KOMUNIKASI #SEAGAMES2022 DI TWITTER MENGGUNAKAN PENDEKATAN SOCIAL NETWORK ANALYSIS (SNA)
Authors: Akbar M Aulia , Masniarara Aziza Balfas Amril  , Raiza Syahira  , Fahrein Rachel Latisha  , Noor Jihan
Published: January 2023

Pesta Olahraga Asia Tenggara atau Southeast Asian Games (SEA Games) merupakan ajang perlombaan di bidang olahraga yang melibatkan negara-negara yang berada di kawasan Asia Tenggara. Para pengguna Twitter ikut memeriahkan acara SEA Games 2022 dengan mengunggah tweet dengan hashtag khusus yaitu #SEAGames2022. Minimnya penelitian mengenai jaringan komunikasi mengenai hiburan menjadi alasan mengapa penelitian ini dilakukan. Metode penelitian yang digunakan adalah Social Network Analysis (SNA) yang berfokus pada relationship research dan digunakan untuk mengukur suatu hubungan dan menggambarkan beberapa informasi dari individu melalui aplikasi Netlytic. Hasil dari penelitian menunjukkan bahwa jaringan komunikasi ini memiliki tipe relasi two mode, tiga jenis pola jaringan yaitu pola komunikasi roda, Y, dan rantai, serta relasi dari jaringan bersifat langsung dan memiliki arah. Penelitian ini juga menunjukkan bahwa terdapat aktor utama, yaitu @greyspolii dengan nilai degree centrality 6.08 serta hubungan antar aktor dalam jaringan komunikasi ini sangat dekat.
TWITTER SEBAGAI MEDIA KOMUNIKASI KRISIS PEMIMPIN PEMERINTAHAN DI INDONESIA (STUDI GELOMBANG COVID-19 VARIAN DELTA DAN OMICRON)
Authors: Priyansyah Rifki Nur , Wibowo Kunto Adi , Fuady Ikhsan
Published: January 2023

Juli 2021, gelombang Delta  menerpa Indonesia  menjadikan negara dengan kasus harian COVID-19 terbanyak di dunia. Angka tersebut  terlampaui pada Februari 2022 dengan kasus harian 55.000 orang. Cuitan Twitter presiden dan  gubernur (Jawa Barat, D.K.I. Jakarta, Jawa Tengah, dan Jawa Timur) selama dua gelombang COVID-19  dikaji dengan menerapkan metode analisis isi untuk melihat perbedaan sifat cuitan antar satu akun dan antara gelombang Delta dengan Omicron. Cuitan diklasifikasikan berdasarkan gaya (request, first-person & second-person), strategi (information, bonding, & action), suasana (optimis, pesimis, netral, & nihil), dan tema (COVID-19, ekologi, ekonomi, politik pemerintahan, sosial budaya, sains). Dari 760 cuitan, 27 di antaranya dianalisis karena tidak memenuhi standar kalimat yang layak. Uji Chi-Square menunjukkan,  Jokowi didominasi oleh pesan first-person, Ganjar didominasi  pesan second-person, Anies didominasi  pesan bonding, dan Khofifah didominasi pesan COVID-19 dibandingkan bukan COVID-19. Dari sisi jenis gelombang, membuktikan bahwa pesan request, first-person, aksi, dan COVID-19 berkurang secara signifikan saat gelombang Omicron dibandingkan gelombang Delta. Penggunaan cuitan optimis cenderung konsisten, baik di antara akun maupun gelombang. Potensi Twitter dalam penggunaan pesan bonding dan aksi sudah digunakan oleh kelima pemimpin. Perbedaan konsentrasi pesan COVID-19 dan aksi tetap perlu dilakukan dengan pertimbangan ahli terkait, terutama dalam kaitannya dengan kesehatan fisik dan mental masyarakat.
BUDAYA PARTISIPASI DAN RESISTENSI KOMUNITAS KEAGAMAAN DI MEDIA SOSIAL
Authors: Gafallo M. Fadhil Yarda , Iriansyah Adibrata , Adiansyah
Published: January 2023

Isu keagamaan merupakan isu yang sering diperbincangkan di tengah masyarakat sosial religius seperti Indonesia. Tanggal 29 Juli 2022 Kementerian Agama Republik Indonesia melakukan Telekonferensi Sidang Isbat pada akun instagram @kemenag_ri. Hasil Sidang Isbat mendapat penolakan langsung oleh pengguna instagram yang termuat dalam kolom komentar. Penelitian ini berfokus pada keterhubungan budaya partisipasi dan ragam penolakan yang terjadi di media sosial instagram. Penelitian ini menggunakan metode netnografi sebagai upaya mendalami interaksi yang terbangun pada komunitas keagamaan. Pengumpulan data dilakukan dengan menggunakan teknik observasi daring pada arsip komentar. Dari total 663 komentar didapatkan 42 pernyataan penolakan yang selanjutnya dianalisis menggunakan pendekatan analisis netnografi. Hasil penelitian ini menemukan aktivitas pengguna instagram menciptakan budaya partisipasi dalam menyikapi tayangan Telekonferensi Sidang Isbat pada akun instagram @kemanag_ri.  Keberagaman pengguna instagram dan ragam bentuk aktivitas partisipasi menghasilkan sikap penolakan. Adapun sikap penolakan dilatar belakangi empat aspek. Pertama, aspek agama. Kedua, aspek sosial. Ketiga aspek politik. Keempat, aspek kebijakan.
NILAI-NILAI KEBANGSAAN DALAM PROGRAM TAYANGAN RELIGI DI STASIUN TELEVISI
Authors: Mubarok Mubarok , Urip Mulyadi
Published: January 2023

Religious broadcast programs on television stations always get the highest quality index compared to other broadcast programs. The results of the Television Broadcasting Program Quality Index Survey conducted by the Indonesian Broadcasting Commission (KPI) always place religious broadcast programs with the best index. This study specifically describes how national values ​​appear in religious broadcast programs on television stations. This research uses critical discourse analysis. The research sample was taken from religious broadcast programs on television stations that aired from January to April 2022. Primary data were obtained from religious broadcasts from television stations. Secondary data in the form of publication data from the Indonesian Broadcasting Commission (KPI). Data analysis was carried out at the micro (textual analysis), meso (discourse analysis), and macro (social context analysis) levels. The results of the study indicate that national values ​​that appear in religious broadcast programs on television are still dominated by normative discourse originating from the state which is associated with Islamic values. This can not be separated from the event's resource persons who come from state sources and there are still few other speakers who discuss national values.
TRAINING OF KHAKASS LANGUAGE TEACHERS IN KHAKASS AUTONOMOUS OBLAST (1943‒1947)
Authors:   Хакасский государственный университет им. Н. Ф. Катанова, Н. Я. Артамонова
Published: January 2023

Цель статьи — раскрыть особенности подготовки учителей хакасского языка и литературы в Хакасской автономной области в период с 1943 по 1947 г. Это время существования в Абаканском учительском институте отделения хакасского языка и литературы с целью подготовки учителей для 5-7 классов национальных школ. В статье раскрыта роль Ф. Г. Исхакова в организации отделения и кафедры хакасского языка и литературы, ее первого заведующего, руководившего разработкой всего комплекса обучающего инструментария, обеспечивавшего учебный процесс вновь образованного подразделения. Отмечены трудности набора абитуриентов и формирования преподавательского коллектива, связанные с историческими условиями, в которых проходила организации отделения, раскрыты мероприятия, нацеленные на преодоление этих трудностей, и проблемы, связанные с обучением будущих педагогов. Отделением созданы условия для дальнейшей подготовки учителей хакасского языка и литературы, имевших высшее педагогическое образование, а также для развития и укрепления хакасского языка, приобретения им новых социальных функций. С 1947 г. прием на специальность «Хакасский язык и литература» продолжил педагогический институт.
Digital transformation and social responsibility: pragmatism or the search for balance
Authors: Izmailova M. A.
Published: January 2023

Purpose: the article defines modern approaches to establishing a balance between digital transformation and the social responsibility of the state and business based on identifying trends and principles for introducing digital technologies into human life, taking into account the priority of social responsibility.

Methods: the study is based on a systematic approach to the digital transformation of society. Within the framework of this approach, the use of the achievements of scientific and technological progress is considered: in public administration – for the purpose of breakthrough development of the country and the interconnected solution of socio-economic problems; in the business sphere – to improve the quality of economic activity and strengthen competitive benefits.

Results: a review of the current state of the digitalizing society, the demand for digital services and satisfaction with the quality of their receipt, the readiness of Russian regions to provide electronic public services. The trends of digital transformation of public administration and the stages of evolution of digital maturity of the state are revealed. It is emphasized that the successful solution of the issues of the digital agenda by the state becomes a stimulating factor in the digital development of business structures. The analysis of digital trends in the business environment has shown their conjugacy with the digitalization of public administration in the presence of a number of differences. The key role of company management in promoting the ideology of digital transformation is noted. Since the use of digital technologies, along with positive effects, can pose a threat to human security, the preservation of his rights and freedom, it becomes necessary to use the concept of social responsibility in carrying out digital transformations of society. The principles of social responsibility in carrying out digital transformations are defined.

Conclusions and Relevance: the processes of digital transformation have firmly entered into all spheres of society. Despite the technological nature, digital development should take place in the logic of a humanistic approach. It is based on the principles of morality, recognition of the inviolability of human rights, with the emphasis on the importance of social responsibility of all actors of digital transformation. At the same time, Russia should build its own model of digital transformation based on respect for dignity, freedom and human rights guaranteed by the Constitution.
Index approach to the assessment of the formation of human capital of the enterprise
Authors: Flek M. B. , Ugnich E. A.
Published: January 2023

Purpose: of the article is to develop a methodology for assessing the formation of an enterprise human capital, which is based on the calculation of indices of formal and informal learning of its employees.

Methods: this article is based on the key provisions of the theory of human capital. The focus of this research is the specific enterprise human capital. The questionnaire method was used, which allowed assessing the development of the enterprise human capital based on the opinions of its direct carriers – employees representing different professional groups. The index method was used. Based on the calculation of the indices of formal and informal learning, the composite indices of the formation of human capital were determined, reflecting the assessment of the actual learning of employees and the desired state in which they feel the need. Visualization of the obtained results is presented in the form of theperception map.

Results: the article presents an improved methodology for assessing the formation of human capital of an enterprise. The assessment of the formation of human capital of various professional groups of employees of the enterprise is carried out. The conducted research has shown that the need for formal and informal learning in various professional groups is differentiated. The essence of the author's position is that one of the most important tasks of the enterprise for the development of human capital is the organization of formal and informal learning of its employees in accordance with the current and future needs of the enterprise itself. The prospects for the development of the enterprise human capital are seen in the development of its vocational education ecosystem by strengthening relationships with educational organizations and other providers of new progressive knowledge, and also by strengthening the relationship between formal and informal learning.

Conclusions and Relevance: the approach to the assessment of the human capital development of an enterprise considered in the article allows us to give practical recommendations on optimizing the organization of learning of the enterprise employees. The results of the study can be used by the professional community, including business leaders, to form a strategy for the development of human capital.
Methodology for assessing the effectiveness of the tax base among redistribution the largest taxpayers
Authors: Zaharova K. A. , Aktaev N. E. , Ivanova N. V.
Published: January 2023

Purpose: the article is aimed at presenting the author’s methodology for evaluating the efficiency of redistribution of the tax base within the consolidated group of taxpayers (hereinafter REAG) the construction of which is based on the determination of relationships and assessment of the degree for influence of tax deductions on the operating profit of the enterprise.

Methods: in the part of the study of the tax base and REAG contributions, methods of applying statistical analysis were used, including the study of the structure and dynamics of tax payments of the enterprise. As part of the construction of the model, this article provides the correlation and regression analysis, providing for several stages related to the application of the specific tax regime of REAG as the significant factor of influence on the process of distribution of the taxable base of the organization. The data of public joint-stock company «Oil company «ROSNEFT» were used to assess the influence on the operating profit of the enterprise of the taxes paid. The graphical analysis was used to visualize the data.

Results: in the course of the study, the degree of influence of the volume for sales of products, selling prices, decrease of the cost and changes in the sales structure on the volume of tax payments of the enterprise was assessed. These factors determine the effectiveness of the REAG’s tax regime, as they represent the company’s profit and therefore affect the amount of income tax. This dependence is reflected in the developed econometric model, which determines the share of each factor in the total income tax of the enterprise, which allows to optimize the tax base of the organization in the future.

Conclusions and Relevance: the analysis revealed the need to improve the efficiency of income tax payment. In response, the methodology for improving the tax regime is proposed. Tax optimization measures include two directions: the process of redistribution of the tax base and the extension of the term for performance of tax obligations within the combined group (from earlier to later). These measures will reduce the risks of taxpayers.
Mapeo sistemático de la literatura acerca de la formación en línea de docentes en servicio
Authors: Rivera Ceseña Karen Patricia , Cordero-Arroyo Graciela , Navarro-Corona Claudia
Published: January 2023

La formación continua en línea de docentes (FeLD) es una modalidad que paulatinamen- te ha ido ganando aceptación en el ámbito internacional en este siglo. A fin de reconocer lo que la investigación ha aportado para la formación de profesores en línea de calidad, este estudio tuvo el propósito de caracterizar la producción académica publicada en el periodo de 2010 a 2020 sobre la formación en línea de docentes, por medio del método de mapeo sistemático de la literatura. El estudio se desarrolló en seis pasos, organizados en tres fases: (fase 1) diseño y selección de los trabajos incluidos en el mapeo, (fase 2) preparación y organización de los metadatos y (fase 3) análisis de contenido. Se incluyeron en el mapeo 22 artículos científicos. Se presenta la tendencia de publicación por temporalidad, por idioma, por ubicación geográfica y por revistas; así mismo, se analizaron las denominaciones que se han aplicado a la FeLD, los objetos de estudio, las metodologías de inves- tigación, los tipos de programas formativos y las características de formación en línea de calidad identificados en cada estudio. Se concluye que los resultados son de utilidad para tomar decisiones en cuanto qué es necesario investigar y cómo hacerlo. Esto permitirá avanzar en la investigación educativa para confirmar si el entorno en línea es una herramienta con el potencial esperado para el desarrollo profesional docente.
Enfoque de ecodiseño en un campus universitario: MSKU cine al aire libre y área de actividades
Authors: Koca Feray , Kahyaoğlu Mehmet Rifat , Beyhan Burak
Published: January 2023

Los sistemas socio-ecológicos evolucionan en ciclos de adaptación ecológica aumentando la resiliencia de los lugares. El objetivo de este artículo es presentar los procesos de diseño e implementación del Proyecto de Área de Actividades y Cine al Aire Libre que se aplica en uno de los valles del Campus Principal de la Universidad Mugla Sitki Koçman. El proyecto se realizó utilizando el enfoque de ecodiseño como método de diseño y planificación basado en los conceptos de panarquía y transecto, que tienen sus raíces en los estudios de Patrick Geddes. Los criterios adoptados para el diseño del área del proyecto fueron determinados por el proceso de levantamiento, análisis y diseño en el marco de las oportunidades que ofrece el entorno en la interacción de la naturaleza y el ser humano. De acuerdo con los criterios básicos de diseño, se completó la fase de aplicación del proyecto y se puso en servicio el Cine al Aire Libre y el Área de Actividades.
Meeting deepwater drilling challenges in Niger-Delta with high performance water-based mud
Authors: Uduba Chimezie Sidney , Fetuga Ibrahim Ademola , Olakoyejo Olabode Thomas , Wobo Monica , Siqueira Antônio Marcos de Oliveira , Gbegudu Joshua Kolawole , Onazi Franklin Onah
Published: January 2023

High performance water-based mud, a drilling fluid type used for deepwater drilling is posed with similar challenges faced by the aqueous water-based mud used for onshore drilling. These challenges emanate due to high temperature condition encountered in deepwater formations. The challenges include decrease in density, viscosity and other rheological properties of the drilling mud under high temperature condition which can lead to failure to meet drilling objectives. An experimental investigation was carried out on the high-performance water-based mud designed for drilling in the Niger delta region where clay type kaolinite is predominant. Four mud samples were formulated by varying the concentration of Sodium Chloride (NaCl) ranging from 3%, 5%, 7%, and 9% and increasing the temperature from surface condition to 140°F. The properties of the high-performance water-based mud was observed at different salinity concentration. The study shows that the density and viscosity tend to increase with increasing temperature where the mud has high salinity concentration of 7% to 9%. Other rheological properties of the high-performance water-based mud increases at increasing temperature but decreases above 118°F except for the 9% NaCl sample which increases with an increasing temperature. The conclusion drawn from this experimental study is that the increase in NaCl concentration increases the density, viscosity and other rheological properties of the high-performance water-based mud when drilling through deep-water formations under high temperature condition. This has provided solution to the deep-water drilling changes.
Computer analysis of regulation of hepatocarcinoma marker genes hypermethylated by HCV proteins
Authors: Antropova E. A. , Khlebodarova T. M. , Demenkov P. S. , Venzel A. S. , Ivanisenko N. V. , Gavrilenko A.  D. , Ivanisenko T.  V. , Adamovskaya A. V. , Revva P. M. , Lavrik I. N. , Ivanisenko V. A.
Published: January 2023

Hepatitis C virus (HCV) is a risk factor that leads to hepatocellular carcinoma (HCC) development. Epigenetic changes are known to play an important role in the molecular genetic mechanisms of virus-induced oncogenesis. Aber rant DNA methylation is a mediator of epigenetic changes that are closely associated with the HCC pathogenesis and considered a biomarker for its early diagnosis. The ANDSystem software package was used to reconstruct and evaluate the statistical significance of the pathways HCV could potentially use to regulate 32 hypermethylated genes in HCC, including both oncosuppressor and protumorigenic ones identified by genome-wide analysis of DNA methylation. The reconstructed pathways included those affecting protein-protein interactions (PPI), gene expression, protein activity, stability, and transport regulations, the expression regulation pathways being statistically significant. It has been shown that 8 out of 10 HCV proteins were involved in these pathways, the HCV NS3 protein being implicated in the largest number of regulatory pathways. NS3 was associated with the regulation of 5 tumor-suppressor genes, which may be the evidence of its central role in HCC pathogenesis. Analysis of the reconstructed pathways has demonstrated that following the transcription factor inhibition caused by binding to viral proteins, the expression of a number of oncosuppressors (WT1, MGMT, SOCS1, P53) was suppressed, while the expression of others (RASF1, RUNX3, WIF1, DAPK1) was activated. Thus, the performed gene-network reconstruction has shown that HCV proteins can influence not only the methylation status of oncosuppressor genes, but also their transcriptional regulation. The results obtained can be used in the search for pharmacological targets to develop new drugs against HCV-induced HCC.
Rational metabolic engineering of Corynebacterium glutamicum to create a producer of L-valine
Authors: Sheremetieva M. E. , Anufriev K. E. , Khlebodarova T. M. , Kolchanov N. A. , Yanenko A. S.
Published: January 2023

L-Valine is one of the nine amino acids that cannot be synthesized de novo by higher organisms and must come from food. This amino acid not only serves as a building block for proteins, but also regulates protein and energy metabolism and participates in neurotransmission. L-Valine is used in the food and pharmaceutical industries, medicine and cosmetics, but primarily as an animal feed additive. Adding L-valine to feed, alone or mixed with other essential amino acids, allows for feeds with lower crude protein content, increases the quality and quantity of pig meat and broiler chicken meat, as well as improves reproductive functions of farm animals. Despite the fact that the market for L-valine is constantly growing, this amino acid is not yet produced in our country. In modern conditions, the creation of strains-producers and organization of L-valine production are especially relevant for Russia. One of the basic microorganisms most commonly used for the creation of amino acid producers, along with Escherichia coli, is the soil bacterium Corynebacterium glutamicum. This review is devoted to the analysis of the main strategies for the development of L- valine producers based on C. glutamicum. Various aspects of L-valine biosynthesis in C. glutamicum are reviewed: process biochemistry, stoichiometry and regulation, enzymes and their corresponding genes, export and import systems, and the relationship of L-valine biosynthesis with central cell metabolism. Key genetic elements for the creation of C. glutamicum-based strains-producers are identified. The use of metabolic engineering to enhance L-valine biosynthesis reactions and to reduce the formation of byproducts is described. The prospects for improving strains in terms of their productivity and technological characteristics are shown. The information presented in the review can be used in the production of producers of other amino acids with a branched side chain, namely L-leucine and L-isoleucine, as well as D-pantothenate.
Validation of a face image assessment technology to study the dynamics of human functional states in the EEG resting-state paradigm
Authors: Savostyanov A. N. , Vergunov E. G. , Saprygin A. E. , Lebedkin D. A.
Published: January 2023

The article presents the results of a study aimed at finding covariates to account for the activity of implicit cognitive processes in conditions of functional rest of the subjects and during them being presented their own or someone else’s face in a joint analysis of EEG experiment data. The proposed approach is based on the analysis of the dynamics of the facial muscles of the subject recorded on video. The pilot study involved 18 healthy volunteers. In the experiment, the subjects were sitting in front of a computer screen and performed the following task: sequentially closed their eyes (three trials of 2 minutes each) and opened them (three trials of the same duration between periods of closed eyes) when the screen was either empty or when it was showing a video recording of their own face or the face of an unfamiliar person of the same gender as the participant. EEG, ECG and a video of the face were recorded for all subjects. In the work a separate subtask of the study was also addressed: validating a technique for assessing the dynamics of the subjects’ facial muscle activity using the recorded videos of the “eyes open” trials to obtain covariates that can be included in subsequent processing along with EEG correlates in neurocognitive experiments with a paradigm that does not involve the performance of active cognitive tasks (“resting-state conditions”). It was shown that the subject’s gender, stimulus type (screen empty or showing own/other face), trial number are accompanied by differences in facial activity and can be used as study-specific covariates. It was concluded that the analysis of the dynamics of facial activity based on video recording of “eyes open” trials can be used as an additional method in neurocognitive research to study implicit cognitive processes associated with the perception of oneself and other, in the functional rest paradigm.
A software system for modeling evolution in a population of organisms with vision, interacting with each other in 3D simulator
Authors: Devyaterikov A. P. , Palyanov A. Yu.
Published: January 2023

Development of computer models imitating the work of the nervous systems of living organisms, taking into account their morphology and electrophysiology, is one of the important and promising branches of computational neurobiology. It is often sought to model not only the nervous system, but also the body, muscles, sensory systems, and a virtual three-dimensional physical environment in which the behavior of an organism can be observed and which provides its sensory systems with adequate data streams that change in response to the movement of the organism. For a system of hundreds or thousands of neurons, one can still hope to determine the necessary parameters and get the functioning of the nervous system more or less similar to that of a living organism – as, for example, in a recent work on the modeling of the Xenopus tadpole. However, of greatest interest, both practical and fundamental, are organisms that have vision, a more complex nervous system, and, accordingly, significantly more advanced cognitive abilities. Determining the structure and parameters of the nervous systems of such organisms is an extremely difficult task. Moreover, at the cellular level they change over time, these including changes under the influence of the streams of sensory signals they perceive and the life experience gained, including the consequences of their own actions under certain circumstances. Knowing the structure of the nervous system and the number of nerve cells forming it, at least approximately, one can try to optimize the initial parameters of the model through artificial evolution, during which virtual organisms will interact and survive, each under the control of its own version of the nervous system. In addition, in principle, the rules by which the brain changes during the life of the organism can also evolve. This work is devoted to the development of a neuroevolutionary simulator capable of performing simultaneous functioning of virtual organisms that have a visual system and are able to interact with each other. The amount of computational resources required for the operation of models of the physical body of an organism, the nervous system and the virtual environment was estimated, and the performance of the simulator on a modern desktop computing system was determined depending on the number of simultaneously simulated organisms.
Inaccesibilidad digital de mujeres emprendedoras en comunidades marginales de Guayaquil-Ecuador
Authors: Vásquez-Luna Luz-Elvira , Proaño Sánchez Fernando , Villón Pérez Nelly Reina , Zamora Ruiz Ingrid Dayana
Published: January 2023

El emprendimiento femenino en comunidades marginales presenta muchos obstáculos para su crecimiento, uno de ellos es la brecha digital por la falta de acceso a internet y el analfabetismo digital En este estudio se expone el testimonio de un grupo de mujeres emprendedoras de una comunidad marginal de Guayaquil en Ecuador, quienes emprenden negocios para cubrir sus necesidades básicas. La metodología utilizada fue de carácter mixta, cualitativa mediante el uso de entrevistas estructuradas y en profundidad utilizando el software NVivo y cuantitativa a través de una encuesta aplicando una regresión logística en SPSS. Los hallazgos de este estudio demuestran el analfabetismo digital de las mujeres emprendedoras de comunidades marginales, quienes requieren de capacitación tecnológica para evitar dificultades a la hora de navegar por la red más aún en los actuales momentos en que debido a la pandemia la mayoría de los negocios aplican estrategias digitales para mantenerse en el mercado.
Vulnerabilidad sísmica en edificaciones de la ciudad de Portoviejo: Reflexiones del 16-A
Authors: Menéndez-Navarro Gema María , García-García Juan Gabriel , Reyna-García Adrián Eliceo
Published: January 2023

Existen muchas reflexiones y conclusiones derivadas luego del evento sísmico del 16 de abril de 2016, suceso que tuvo un fuerte impacto en las infraestructuras de la denominada zona cero de la ciudad de Portoviejo, en algunos casos reconfigurando su dinámica urbana y de movilidad. El rol de los profesionales es una de las aristas más cuestionadas por la comunidad luego del daño que sufrieron edificios y otras obras civiles, provocando grandes pérdidas económicas y humanas. El objetivo de la investigación es el de identificar la vulnerabilidad sísmica a las que están expuestas las infraestructuras ante sismos a partir de la experiencia vivida con el terremoto del 16-A, empleando una metodología de investigación documental (bibliográfica) y de campo (encuestas), aplicadas a los actores del sector de la construcción. Los resultados obtenidos evidencian que el sector antes mencionado, con todas sus ramas implícitas, requiere de constante capacitación y actualización de conocimientos y técnicas constructivas modernas.
Evaluating E-learning system success in higher education during the Covid-19
Authors: Ozdamli Fezile , Mohammed Noori Narmin
Published: January 2023

Human lives globally have been affected by the COVID-19 pandemic. The quantitative research method was followed to assess e-learning system success from students' perspectives during the pandemic. ISS and USAT model was adopted to measure it, and a survey was used to collect 632 voluntary students. The regression analysis method presented variations between the quality of factors that anticipate user-perceived satisfaction, system use, and individual performance. While the quality factors suggested the impact of the dependent variable was (collaboration, information, service, System, IATE, DIA, LCAx, and LPIWO). In students' opinion, the study found quality factors significantly positively influence the adopted model, except for the QSer and IATE. The study outcome is expected to help academic staff and learners with further research.
Keywords: E-learning, distance education, students' opinion, DeL& McL model, USAT model
Mediating Peace through Local Tradition of Cross-Religious Community in Saparua Island, Moluccas
Authors: Toisuta Hasbollah , Wakano Abidin , Huda Miftahul
Published: January 2023

On Saparua Island in the Moluccas, Indonesia, local tradition guides the interreligious community of Muslims and Christians. Issues relating to people's races, religions, and ethnic backgrounds frequently spark conflict in the community. At the moment, it is working on maintaining and advancing peace. This article presents an investigation into the factors that contribute to religious harmony in communities comprised of members of different faiths. This research was conducted on Saparua Island through observation and interviews with community figures and members of the religious, academic, youth, and female communities. It was hypothesized, and subsequent research confirmed, that the community adheres to the principles of peace and the way of life espoused by the "Basudara People" in Ale Rasa Beta Rasa, Sagu Salempeng Patah Dua, and Sei Leli Hatulo-Hatuli Eleli Esepei. Peace in the cross-religious community can be achieved through the practice of local traditions like Pela Gandong and Masohi, which are forms of community cooperation. As a consequence of this, the result demonstrates the significance of having dialogues between people of different religious and cultural backgrounds to keep and maintain the viability of interreligious peace. Tradisi lokal di Pulau Saparua, Maluku, Indonesia menjadi panduan moral (norma) bagi kehidupan komunitas lintas agama (Muslim-Kristiani) yang pernah terjadi konflik dipicu isu Suku, Agama, Ras dan saat ini sedang berproses merawat dan membangun perdamaian. Dalam artikel ini, perdamaian komunitas lintas agama dianalisis melalui tradisi lokal sebagai kriterianya. Penelitian ini didasari oleh observasi dan wawancara di antara tokoh adat, tokoh agama, tokoh pemuda, pemerhati perempuan, akademisi, dan masyarakat di Pulau Saparua. Diprediksi dan ditemukan bahwa prinsip perdamaian dari filosofi hidup “Basudara People” pada Ale Rasa Beta Rasa, Sagu Salempeng Patah Dua, dan Sei Leli Hatulo-Hatuli Eleli Esepei. Perdamaian melalui tradisi lokal Pela Gandong dan Masohi sebagai kerjasama untuk saling membantu komunitas lintas agama. Dengan demikian, hasil menunjukkan pentingnya dialogis tokoh lintas agama dan tokoh adat untuk menjaga dan memelihara keberlanjutan perdamaian lintas agama.
The Growth of Black Intellectual and the School Education in A Quantum Life
Authors:   The Korean Society For Teaching English Literature, Hahn Meeya
Published: January 2023

This article attempts to examine the effects of Du Bois’ “Double-Consciousness” and American educational systems on African-American man by analyzing Hakeem Oluseyi’s A Quantum Life. Through this African-American physicist’s autobiography, we could specifically learn about life of poverty and the violence, along with dissolution of family which he had to go through. Racism in American society is ubiquitous and has detrimental effect on black people’s life. Du Bois has explained how African Americans suffer from “Double-Consciousness,” inward “twoness,” experienced by African-Americans in a white-dominated society. Considering that human’s identity forms at the junction of mutual interaction with others, Du Bois’ “Double-Consciousness” could be regarded as the condition of existence not only of African-Americans but of the humanity as a whole. However, African American’s “Double-Consciousness” is problematic in that the norms in their society have a deadly effect on them. The institutional education helped Hakeem to overcome self-loathing or sense of skepticism and become a physicist. The normative cultural assets passed down by white elites at his school provided Hakeem with the opportunity to work and study at the best physics educational institutions. Through Hakeem’s story, we can confirm that black people in the United States need special support, both tangible and intangible, to overcome the detrimental effect of racism on them.
Advances in understanding the development and morphology of the poultry breast muscle: impact on meat quality
Authors:   The Ohio State University, USA, Velleman Sandra G.
Published: January 2023

In recent years, selection programs in meat-type poultry have placed an emphasis on growth rate, muscling, and feed conversion. Although substantial improvements have been made, there have been modification in the morphological structure of the muscle, muscle regeneration mechanisms, and meat quality especially in the breast muscle. In terms of the morphological structure of the breast muscle, muscle fiber diameters have increased, connective tissue spacing has decreased leading to reduced capillary supply, and cellular activity of the satellite cell population has been altered. Many of the necrotic/fibrotic myopathies like Wooden Breast are likely associated with these changes in breast muscle structure and cellular biology. This chapter discusses muscle growth mechanisms and how changes in the cell biology of the breast muscle are related to breast muscle myopathies occurring in meat-type birds.
Nutritional strategies and management practices to improve poultry meat quality
Authors:   Alma Mater Studiorum – Università di Bologna, Italy, Zampiga Marco , Sirri Federico ,   Alma Mater Studiorum – Università di Bologna, Italy
Published: January 2023

The concept of meat quality is of primary relevance for both producers, due to the implications for fresh retail and value-added meat products, and consumers, which are increasingly aware of the nutritional quality of food. Beside the genetic background, many environmental factors are able to influence meat quality traits in poultry. For instance, nutrition is considered as one of the most important determinants of poultry meat quality due to its effects on proximate composition, technological properties, oxidative stability and sensory traits. Furthermore, nutritional strategies can also play a role in limiting the negative consequences exerted on meat quality by certain conditions to which modern broiler lines are particularly susceptible, such as muscle abnormalities and heat stress. From another perspective, some management practices can also provide relevant benefits in terms of meat quality. In this context, the ancient practice known as “caponization” (i.e. castration) can deeply modify meat and carcass quality by changing the animal metabolism, providing to the consumers a high-quality alternative to conventional chicken meat. The aim of this chapter is, therefore, to summarize the most relevant findings concerning the effects of nutrition and feeding strategies on the different facets of the meat quality concept as well as to discuss the consequences of some environmental and management factors, such as heat stress and caponization, on this crucial topic for the modern poultry industry.
Understanding texture development in poultry meat
Authors:   University of Arkansas, USA, Maynard Clay J. , Owens Casey M. ,   University of Arkansas, USA
Published: January 2023

This chapter is intended to inform the reader on advances and developmental strategies in poultry meat tenderness. As is common with all food products, texture or tenderness, as the terms are interchangeably used, is the final “grade” that consumers place on a product. Meat tenderness is commonly known to be the hardest predicted trait for meat products as each consumer has their own level of acceptance. It should also be noted that texture development is a very intricate process that is multifaceted. The discussion to follow will focus on this multitude of factors that affect texture development and to express how complex final meat tenderness is in poultry products.
Quality defects associated with poultry muscle development: white striping
Authors:   National Center for Genetic Engineering and Biotechnology, Thailand, Malila Yuwares , Thanatsang Krittaporn V. ,   National Center for Genetic Engineering and Biotechnology, Thailand, Srimarut Yanee ,   National Center for Genetic Engineering and Biotechnology, Thailand
Published: January 2023

White striping (WS) is characterized by the appearance of white lines parallel to the direction of muscle fibers on the surface of chicken breast meat. Over the past twenty years WS has become a significant concern in the poultry industry. WS not only alters technological properties of affected meat but impacts nutritional quality and consumer acceptance. This chapter summarizes current knowledge on the impacts of WS on meat quality, biological changes within affected muscle, as well as the potential factors associated with development of WS. The chapter also reviews potential strategies for mitigating WS.
Factors affecting shelf life of poultry meat
Authors:   Universidad de Extremadura, Spain, González-Mohíno Alberto , Estévez Mario ,   Universidad de Extremadura, Spain
Published: January 2023

Poultry meat and meat products are highly susceptible to both oxidative and microbial spoilage. This chapter reviews recent progress in understanding of the mechanisms behind microbial spoilage as well as lipid and protein oxidation. These understanding enables design and implementation of novel and effective antioxidant and antimicrobial strategies to extend shelf life. The chapter discusses current research on interventions such as modifying diets of birds before slaughter, the use of novel antioxidant and antimicrobial compounds in poultry products and developments in packaging.