bluuebunny/crossref_metadata_2025 huggingface dataset:
Pour un outil de gestion des collections de périodiques et des espaces de rangement
Authors: Cauchon Laurent , Tessier Mario
Published: June 2015

L’article présente l’expérience du Centre de ressources documentaires Alain-Grandbois en matière de conservation des collections de périodiques. On y décrit l’élaboration d’un outil quantitatif de gestion des collections et des espaces physiques de rangement. Une méthode concrète et efficace permet un inventaire précis et un suivi rigoureux ainsi que des prévisions servant à optimiser à la fois l’espace de rangement et les délais de conservation. La méthodologie employée repose sur le système des entrées/sorties afin recueillir des données sur les espaces utilisés.
D’hier à demain, les bibliothèques de l’État québécois : la parlementaire et les administratives
Authors: Bernier Gaston , Bourret Johanne
Published: June 2015

L’État québécois met à la portée de la Fonction publique et de la représentation nationale un réseau de bibliothèques intérieures : les bibliothèques administratives et la bibliothèque législative. Elles varient fondamentalement les unes des autres selon leurs fonction et rôles, leurs structures internes, les crédits qu’on leur alloue, les services qu’elles offrent, leur personnel, leur lectorat et, enfin, les collections qu’elles conservent ou mettent à disposition.
La documentation en milieu communautaire au Québec : entre menaces et avancées
Authors: Leclair Julie
Published: June 2015

Après plus de 40 ans de pratiques communautaires et à l’ère des partenariats et de la médiation, le portrait des centres de documentation en milieu communautaire n’est pourtant guère reluisant. Quelles sont les particularités de la documentation en milieu communautaire ? Quels rôles jouent les centres de documentation présents dans ce milieu et quels sont les enjeux auxquels ils doivent faire face ?
Les associations professionnelles en sciences de l’information au Québec
Authors: Lajeunesse Marcel
Published: June 2015

Depuis 1932, sept associations professionnelles ont été créées en sciences de l’information au Québec, six en bibliothéconomie et une en archivistique. Chacune a ses buts, ses objectifs, sa mission propre qui définissent son action. Ces associations sont de dimension modeste. Les plus importantes (l’Association pour l’avancement des sciences et des techniques de la documentation, la Corporation des bibliothécaires professionnels du Québec et l’Association des archivistes du Québec) rassemblent entre 500 et 750 membres et offrent les services d’un secrétariat permanent. Ces associations se sont dotées récemment d’un organisme de concertation, la Table des milieux documentaire et archivistique du Québec, pour mieux coordonner leur action et faire front commun auprès des gouvernements et des médias.
Les bibliothécaires québécois et les échanges internationaux
Authors: Savard Réjean
Published: June 2015

L’auteur relève les principales occasions où les bibliothécaires québécois ont participé à des échanges internationaux sur le plan professionnel. C’est surtout avec la Révolution tranquille que les échanges internationaux se sont développés chez les bibliothécaires québécois, particulièrement avec la France et la Francophonie. L’auteur discute également de la participation québécoise au sein de la Fédération internationale des associations de bibliothèques et institutions (IFLA).
El devenir de los árboles: ejemplares históricos vinculados a José de San Martín (siglos XIX y XX)
Authors: Blasco María Elida
Published: June 2015

This article seeks to reconstruct the history of a type of cultural practice developed in Argentina between the end of the 19th century and the middle of the 20th century, which propitiated the production, reproduction and consumption of arguments that assigned historical value to the associates of José de San Martín (1778-1850), who is considered the “Father of the Country” within the pantheon of the founding fathers of Argentina. Hence, the general objective is to analyze the particularities of the process of constructing the foundational myths of the nation, emphasizing the cult of the “heroes,” and exploring the rise of entities in which the feelings of national identity associated with them are enshrined.
Renewed inflation of Long Valley Caldera, California (2011 to 2014)
Authors: Montgomery‐Brown E. K. , Wicks C. W. , Cervelli P. F. , Langbein J. O. , Svarc J. L. , Shelly D. R. , Hill D. P. , Lisowski M.
Published: June 2015

Slow inflation began at Long Valley Caldera in late 2011, coinciding with renewed swarm seismicity. Ongoing deformation is concentrated within the caldera. We analyze this deformation using a combination of GPS and InSAR (TerraSAR‐X) data processed with a persistent scatterer technique. The extension rate of the dome‐crossing baseline during this episode (CA99 to KRAC) is 1 cm/yr, similar to past inflation episodes (1990–1995 and 2002–2003), and about a tenth of the peak rate observed during the 1997 unrest. The current deformation is well modeled by the inflation of a prolate spheroidal magma reservoir ∼7 km beneath the resurgent dome, with a volume change of ∼6 × 106 m3/yr from 2011.7 through the end of 2014. The current data cannot resolve a second source, which was required to model the 1997 episode. This source appears to be in the same region as previous inflation episodes, suggesting a persistent reservoir.
How well do simulated last glacial maximum tropical temperatures constrain equilibrium climate sensitivity?
Authors: Hopcroft Peter O. , Valdes Paul J.
Published: June 2015

Previous work demonstrated a significant correlation between tropical surface air temperature and equilibrium climate sensitivity (ECS) in PMIP (Paleoclimate Modelling Intercomparison Project) phase 2 model simulations of the last glacial maximum (LGM). This implies that reconstructed LGM cooling in this region could provide information about the climate system ECS value. We analyze results from new simulations of the LGM performed as part of Coupled Model Intercomparison Project (CMIP5) and PMIP phase 3. These results show no consistent relationship between the LGM tropical cooling and ECS. A radiative forcing and feedback analysis shows that a number of factors are responsible for this decoupling, some of which are related to vegetation and aerosol feedbacks. While several of the processes identified are LGM specific and do not impact on elevated CO2 simulations, this analysis demonstrates one area where the newer CMIP5 models behave in a qualitatively different manner compared with the older ensemble. The results imply that so‐called Earth System components such as vegetation and aerosols can have a significant impact on the climate response in LGM simulations, and this should be taken into account in future analyses.
Reversibly Triggered Protein–Ligand Assemblies in Giant Vesicles
Authors: Peters Ruud J. R. W. , Nijemeisland Marlies , van Hest Jan C. M.
Published: June 2015

External small‐molecule triggers were used to reversibly control dynamic protein–ligand interactions in giant vesicles. An alcohol dehydrogenase was employed to increase or decrease the interior pH upon conversion of two different small‐molecule substrates, thereby modulating the pH‐sensitive interaction between a Ni‐NTA ligand on the vesicle membrane and an oligohistidine‐tagged protein in the lumen. By alternating the small‐molecule substrates the interaction could be reversed.
Severe open angle glaucoma in hereditary hemorrhagic telangiectasia
Authors: Kuchtey Rachel W. , Naratadam George T. , Kuchtey John
Published: June 2015

Key clinical message

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease. Conjunctival telangiectasias and retinal vascular malformations are known ocular manifestations. We report here the first case of open angle glaucoma in a patient with HHT caused by a nonsense mutation, C471X in the ACVRL1 gene.
Dual Catalytic Activity of Palladium Doped with a Rhodium Complex in a One‐pot, Four Step Process
Authors: Shapiro Leora , Driess Matthias , Avnir David
Published: June 2015

The extraction of the two competing reactions from the same catalyst—a composite catalytic‐complex@catalytic‐metal—is reported. A Wilkinson rhodium based catalyst entrapped within metallic palladium catalyst is shown to perform both hydroformylation and hydrogenation with a ratio that depends on H2 and CO pressures. Here we demonstrate this special reactivity in a one‐pot, four step sequence, which include hydroformylations of phenyl acetylenes, reduction of nitrobenzene to aniline, carbonyl‐amine condensations forming imines; and imine reductions.
In Honour of the 70th Birthday of Professor Luis A. Oro
Authors: Lahoz Fernando J. , Pérez‐Torrente Jesús J.
Published: June 2015

When Professor Luis Oro turns over the middle of June, he will be 70 years old, and he will be completing a cycle of almost half a century (48 years) dedicated to chemical research in the field of organometallics and homogeneous catalysis, and in general to the development of chemistry. In this aim, he has assumed different and complementary responsibilities, from leading innovative research projects, to the formation of professional scientists for academia or the chemical industry, from the direction of the Spanish Royal Society of Chemistry, to that of diverse editorial management consortia or even having taken the responsibility of guiding the overall Spanish scientific policy.

It has been a long trek done with tons of enthusiasm, excellent companions and plenty of generosity. It is our pleasure and privilege to walk around the main steps of Professor Oro’s life; a life dedicated to investigate and to work to situate chemical research, and science in general, in the proper place it should be in our modern society.
Shape Persistence of Polyproline II Helical Oligoprolines
Authors: Garbuio Luca , Lewandowski Bartosz , Wilhelm Patrick , Ziegler Ludmila , Yulikov Maxim , Wennemers Helma , Jeschke Gunnar
Published: June 2015

Oligoprolines are commonly used as molecular scaffolds. Past studies on the persistence length of their secondary structure, the polyproline II (PPII) helix, and on the fraction of backbonecisamide bonds have provided conflicting results. We resolved this debate by studying a series of spin‐labeled proline octadecamers with EPR spectroscopy. Distance distributions between an N‐terminal GdIII‐DOTA (DOTA=1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid) label and a nitroxide label at one of five evenly spaced backbone sites allowed us to discriminate between the flexibility of the PPII helix and thecisamide contributions. An upper limit of 2 %cisamide bonds per residue was found in a 7:3 (v/v) water/glycerol mixture, whereascisamides were not observed in trifluoroethanol. Extrapolation of Monte Carlo models from the glass transition to ambient temperature predicts a persistence length of ≈3–3.5 nm in both solvents. The method is generally applicable to any type of oligomer for which the persistence length is of interest.
ChemInform Abstract: Hexagonal Ferrites of X‐, W‐, and M‐Type in the System Sr—Fe—O: A Comparative Study.
Authors: Toepfer Joerg , Seifert Daniela , Le Breton Jean‐Marie , Langenhorst Falko , Chlan Vojtech , Kouril Karel , Stepankova Helena
Published: June 2015

While investigating the Fe‐rich part of the pseudo‐binary system SrO—Fe2O3, the well‐known M‐type SrFe12O19 (I) and two additional ferrites, W‐type SrFeII2FeIII16O27 (II) and X‐type Sr2FeII2FeIII28 O46 (III) are found at high temperatures from calcined and sintered mixtures of SrCO3 and Fe2O3 (1200 °C for (I); 1370 °C for (III); 1400 °C for (II), all 24 h).
ChemInform Abstract: Synthesis, Structure, Thermoelectric Properties, and Band Gaps of Alkali Metal Containing Type I Clathrates: A8Ga8Si38 (A: K, Rb, Cs) and K8Al8Si38.
Authors: Sui Fan , He Hua , Bobev Svilen , Zhao Jing , Osterloh Frank E. , Kauzlarich Susan M.
Published: June 2015

A series of M8Ga8Si38 (M: K, Rb, Cs) compounds with type I clathrate structure and K8Al8Si38 are prepared by heating 9:8:38 molar mixtures of the alkali metal, Ga or Al, and Si.
ChemInform Abstract: Li2Cu2O(SO4)2: A Possible Electrode for Sustainable Li‐Based Batteries Showing a 4.7 V Redox Activity vs Li+/Li0.
Authors: Sun Meiling , Rousse Gwenaelle , Abakumov Artem M. , Saubanere Matthieu , Doublet Marie‐Liesse , Rodriguez‐Carvajal Juan , Van Tendeloo Gustaaf , Tarascon Jean‐Marie
Published: June 2015

Phase pure Li2Cu2O(SO4)2 is prepared by ball milling and heating of stoichiometric amounts of Li2O and dried CuSO4 under Ar (alumina crucible, 400 °C, 4 d).
ChemInform Abstract: Tetracyanido(difluorido)phosphates M+[PF2(CN)4]‐.
Authors: Bresien Jonas , Ellinger Stefan , Harloff Joerg , Schulz Axel , Sievert Katharina , Stoffers Alrik , Taeschler Christoph , Villinger Alexander , Zur Taeschler Cornelia
Published: June 2015

A series of salts containing the unprecedented [cis‐PF2(CN)4]‐ ion is prepared and their structures are determined by single crystal XRD.
ChemInform Abstract: Low Temperature Synthesis and Characterization of Na—M—(O)—F Phases with M: Ti, V.
Authors: Nava‐Avendano Jessica , Ayllon Jose A. , Frontera Carlos , Oro‐Sole Judith , Estruga Marc , Molins Elies , Palacin M. Rosa
Published: June 2015

Agglomerates of spherical Na5‐δTi3O3‐ δF11+δ (δ ≈0.3) nanoparticles are obtained by repeated microwave heating of an aqueous solution of H2TiF6 and Na(OAc) in a domestic microwave oven (800 W, 20 s).
ChemInform Abstract: Synthesis and Characterization of the Quaternary Scandium Uranium Selenide CsScUSe3(Se2).
Authors: Ward Matthew D. , Lee Minseong , Choi Eun Sang , Ibers James A.
Published: June 2015

The title compound is prepared by solid state reaction of a 1:1:3:4.7 molar mixture of U, Sc, Se, and CsCl, the latter acting as reactive flux (evacuated silica tubes, 1173 K, 6 h).
ChemInform Abstract: Unexpected Actinyl Cation‐Directed Structural Variation in Neptunyl(VI) A‐Type Tri‐Lacunary Heteropolyoxotungstate Complexes.
Authors: Berg John M. , Gaunt Andrew J. , May Iain , Pugmire Alison L. , Reilly Sean D. , Scott Brian L. , Wilkerson Marianne P.
Published: June 2015

Addition of excess NH4Cl to an aqueous solution containing {NpO2}2+ and Na8H[A‐β‐PW9O34] leads to the unexpected formation of (NH4)13 [Na(NpO2)2 (A‐α‐PW9O34)2] ·12H2O, which is characterized by single crystal XRD, UV/VIS/NIR, and IR spectroscopy.
ChemInform Abstract: Enantioselective Synthesis of α‐Quaternary Mannich Adducts by Palladium‐Catalyzed Allylic Alkylation: Total Synthesis of (+)‐Sibirinine.
Authors: Numajiri Yoshitaka , Pritchett Beau P. , Chiyoda Koji , Stoltz Brian M.
Published: June 2015

A two step sequence consisting of a Mannich reaction followed by a decarboxylative enantioselective allylic alkylation reaction is developed to provide a novel access to α‐quarternary Mannich type products.
ChemInform Abstract: Facile Dearomatization of Nitroquinolines Through [3 + 2] and [4 + 2] Cycloaddition Reactions.
Authors: Bastrakov Maxim A. , Starosotnikov Alexey M. , Kachala Vadim V. , Fedyanin Ivan V. , Shevelev Svyatoslav A.
Published: June 2015

An efficient method is developed for the functionalization of nitroquinolines by employing pericyclic [3+2] and [4+2] cycloaddition reactions.
ChemInform Abstract: Highly Enantioselective Catalytic Asymmetric [2 + 2] Cycloadditions of Cyclic α‐Alkylidene β‐Oxo Imides with Ynamides.
Authors: Enomoto Kazuaki , Oyama Harufumi , Nakada Masahisa
Published: June 2015

The asymmetric [2 + 2] cycloaddition of cyclic α‐alkylidene β‐oxo imides (I), (IV), and (VI) with ynamides (II) is reported.
ChemInform Abstract: Base‐Mediated Decomposition of Amide‐Substituted Furfuryl Tosylhydrazones: Synthesis and Cytotoxic Activities of Enynyl‐Ketoamides.
Authors: Ji Fanghua , Peng Hui , Zhang Xiaoting , Lu Wenhua , Liu Shubin , Jiang Huanfeng , Liu Bo , Yin Biaolin
Published: June 2015

LiOtBu mediated decomposition of furfuryl tosylhydrazones affords enynyl substituted carbonyl compounds.
ChemInform Abstract: Cobalt(III)‐Catalyzed Synthesis of Indazoles and Furans by C—H Bond Functionalization/Addition/Cyclization Cascades.
Authors: Hummel Joshua R. , Ellman Jonathan A.
Published: June 2015

A new air‐stable cationic Co(III) catalyst is used for the convergent, one‐step preparation of N‐aryl‐2H‐indazoles and furans from azobenzenes and aldehydes.
ChemInform Abstract: Iodine‐Mediated Diastereoselective Cyclopropanation of Arylidene Malononotriles by 2,6‐Dimethylquinoline.
Authors: Yavari Issa , Hosseinpour Reza , Skoulika Stavroula
Published: June 2015

The facile one‐pot transformation provides trans‐2‐aryl‐3‐(6‐methylquinolin‐2‐yl)cyclopropane‐1,1‐dicarbonitriles in moderate to good yields.
ChemInform Abstract: A Base‐Controlled Chemoselective Transfer Hydrogenation of α,β‐Unsaturated Ketones Catalyzed by [IrCp*Cl2]2 with 2‐Propanol.
Authors: Chen Shu‐jie , Lu Guo‐ping , Cai Chun
Published: June 2015

Depending on the base, a wide range of α,β‐unsaturated ketones are reduced to saturated ketones or alcohols by using a simple homogeneous catalytic system based on the commercially available Iridium catalyst under optimized reaction conditions.
ChemInform Abstract: Cobalt‐Catalyzed Cross‐Dehydrogenative Coupling Reaction in Water by Visible Light.
Authors: Wu Cheng‐Juan , Zhong Jian‐Ji , Meng Qing‐Yuan , Lei Tao , Gao Xue‐Wang , Tung Chen‐Ho , Wu Li‐Zhu
Published: June 2015

Tetrahydroisoquinolines (I) and indoles (II) and (IV) are regioselectively coupled using CoCl2/DMG as photosensitizer and blue LEDs.
ChemInform Abstract: Differential Reactivity of Fluorinated Homopropargylic Amino Esters vs Gold(I) Salts. The Role of the Nitrogen Protecting Group.
Authors: Sanchez‐Rosello Maria , Miro Javier , del Pozo Carlos , Fustero Santos
Published: June 2015

The gold(I)‐catalyzed hydroarylation/isomerization reaction of N‐protected homopropargyl amino esters (III) gives quinoline derivatives of type (IV).
ChemInform Abstract: Fmox: A Base‐Labile Aldehyde Protecting Group.
Authors: Diness Frederik , Meldal Morten
Published: June 2015

Two routes for the introduction of a novel 3‐Fmoc‐(1,3)‐oxazine aldehyde protecting group named Fmox are presented.
ChemInform Abstract: Chemoselective Deprotection and Deprotection with Concomitant Reduction of 1,3‐Dioxolanes, Acetals and Ketals Using Nickel Boride.
Authors: Khurana Jitender M. , Dawra Kiran , Sharma Purnima
Published: June 2015

The deprotection of acetals and ketals using in situ generated nickel boride is described.
ChemInform Abstract: Highly Efficient and Chemoselective Zinc‐Catalyzed Hydrosilylation of Esters under Mild Conditions.
Authors: Kovalenko Oleksandr O. , Adolfsson Hans
Published: June 2015

An efficient procedure is elaborated for the conversion of esters into alcohols via a hydrosilylation [32 examples].
ChemInform Abstract: Catalytic Asymmetric Henry Reaction of Nitroalkanes and Aldehydes Catalyzed by a Chiral N,N′‐Dioxide/Cu(I) Complex.
Authors: Mei Hongjiang , Xiao Xiao , Zhao Xiaohu , Fang Bing , Liu Xiaohua , Lin Lili , Feng Xiaoming
Published: June 2015

The asymmetric nitroaldol reaction of nitroethane with aromatic, heteroaromatic, or α,β‐unsaturated aldehydes gives the anti‐β‐nitroalcohols as main isomers.
ChemInform Abstract: Enantioselective Copper(I)‐Phosphoramidite Catalyzed Addition of Alkylzirconium Species to Acyclic Enones.
Authors: Roth Philippe M. C. , Fletcher Stephen P.
Published: June 2015

A variety of functionalized alkylzirconium nucleophiles can be used in the mild and convenient presented method.
ChemInform Abstract: A Novel Aromatic Carbocation‐Based Coupling Reagent for Esterification and Amidation Reactions.
Authors: Nguyen Thanh V. , Lyons Demelza J. M.
Published: June 2015

Chlorotropylium chloride is successfully applied as a novel coupling reagent for the two‐step esterification and amidation reactions of different carboxylic acids.
ChemInform Abstract: Cleavage of C—N Bonds in Guanidine Derivatives and Its Relevance to Efficient C—N Bonds Formation.
Authors: Chang Denghu , Zhu Dan , Zou Peng , Shi Lei
Published: June 2015

Diarylguanidines are converted to amides by copper(II)‐salts in the presence of palladium acetate.
ChemInform Abstract: Variations in the Blaise Reaction: Conceptually New Synthesis of 3‐Amino Enones and 1,3‐Diketones.
Authors: Rao H. Surya Prakash , Muthanna Nandurka
Published: June 2015

The coupling reactions of 2‐bromoketones with nitriles results in the formation of 3‐amino enones or 1,3‐diketones depending on the hydrolysis conditions.
ChemInform Abstract: Iron‐Catalyzed C—N Bond Formation via the Beckmann Rearrangement.
Authors: Jefferies Latisha R. , Weber Savannah R. , Cook Silas P.
Published: June 2015

The presented transformation of oximes is performed under mild conditions and does not require an inert atmosphere.
ChemInform Abstract: Pd‐Catalyzed Monoselective ortho‐C—H Alkylation of N‐Quinolyl Benzamides: Evidence for Stereoretentive Coupling of Secondary Alkyl Iodides.
Authors: Zhang Shu‐Yu , Li Qiong , He Gang , Nack William A. , Chen Gong
Published: June 2015

A method for the monoselective alkylation of ortho‐C—H bonds of N‐quinolyl benzamides with both primary and secondary alkyl halides under palladium catalysis is reported.
ChemInform Abstract: Copper‐Catalyzed Synthesis of Weinreb Amides by Oxidative Amidation of Alcohols.
Authors: Yedage Subhash L. , Bhanage Bhalchandra M.
Published: June 2015

The efficient reaction protocol delivers various aryl and hetaryl substituted Weinreb amides in high yields.
ChemInform Abstract: A Phosphetane Catalyzes Deoxygenative Condensation of α‐Keto Esters and Carboxylic Acids via PIII/PV=O Redox Cycling.
Authors: Zhao Wei , Yan Patrick K. , Radosevich Alexander T.
Published: June 2015

Reduction of the P‐oxide APO with PhSiH3 affords a tricoordinate aminophosphetane which promotes the title reaction to produce α‐acyloxy esters with a high functional group compatibility.
ChemInform Abstract: Nickel‐Catalyzed and Benzoic Acid‐Promoted Direct Sulfenylation of Unactivated Arenes.
Authors: Yang Ke , Wang Yuqi , Chen Xinyong , Kadi Adnan A. , Fun Hoong‐Kun , Sun Hao , Zhang Yan , Lu Hongjian
Published: June 2015

Depending on substitution pattern, N‐(2‐(pyridin‐2‐yl)propan‐2‐yl)arylamides are regioselectively mono‐ and/or bis‐arylsulfenylated with diaryl disulfides (II) and (IX) in the ortho‐position(s) next to the amide group.
ChemInform Abstract: Pd(II)‐Catalyzed Allylic C—H Amination for the Preparation of 1,2‐ and 1,3‐Cyclic Ureas.
Authors: Nishikawa Yasuhiro , Kimura Seikou , Kato Yuri , Yamazaki Natsuka , Hara Osamu
Published: June 2015

A general procedure for the synthesis of the title compounds by intramolecular allylic C—H amination is developed.
ChemInform Abstract: Synthesis of Adamantyl Substituted 1,2,3‐Triazol‐5‐ylidene Ligands and Their PEPPSI‐Type Palladium Complexes.
Authors: Mitsui Takashi , Sugihara Masato , Tokoro Yuichiro , Fukuzawa Shin‐ichi
Published: June 2015

The synthesized catalysts are applied in Hiyama and Suzuki‐Miyaura couplings providing biaryls in good to excellent yields.
ChemInform Abstract: Facile Construction of Symmetric Biaryls using (BeDABCO)2Pd2Cl6 as an Efficient and Highly Active Catalyst under Microwave Irradiation.
Authors: Hajipour Abdol Reza , Rafiee Fatemeh
Published: June 2015

Aryl chlorides and iodides give similar yields.
ChemInform Abstract: Aminocatalytic Cross‐Coupling Approach via Iminium Ions to Different C—C Bonds.
Authors: Mupparapu Nagaraju , Battini Narsaiah , Battula Satyanarayana , Khan Shahnawaz , Vishwakarma Ram A. , Ahmed Qazi Naveed
Published: June 2015

The pyrrolidine‐catalyzed aerobic cross‐coupling of glyoxals (I) with phenols, naphthols, indoles, and pyrroles as nucleophiles leads to diones (III) [42 examples].
ChemInform Abstract: Cyclopropanation Using Flow‐Generated Diazo Compounds.
Authors: Roda Nuria M. , Tran Duc N. , Battilocchio Claudio , Labes Ricardo , Ingham Richard J. , Hawkins Joel M. , Ley Steven V.
Published: June 2015

A method for the cyclopropanation of electron‐poor olefins using unstabilized diazo compounds generated under continuous flow conditions and room temperature is developed.
ChemInform Abstract: Stereoselective Synthesis of Highly Functionalized Indanes and Dibenzocycloheptadienes Through Complex Radical Cascade Reactions.
Authors: Kong Wangqing , Fuentes Noelia , Garcia‐Dominguez Andres , Merino Estibaliz , Nevado Cristina
Published: June 2015

Two highly stereoselective radical‐mediated syntheses of densely functionalized indanes and dibenzocycloheptadienes from ortho‐vinyl‐ and ortho‐vinylaryl‐substituted N‐(arylsulfonyl)‐acrylamides, respectively, are presented.
ChemInform Abstract: Synthesis of the First Completely Spin‐Compatible N@C60 Cyclopropane Derivatives by Carefully Tuning the DBU Base Catalyst.
Authors: Zhou Shen , Rasovic Ilija , Briggs G. Andrew D. , Porfyrakis Kyriakos
Published: June 2015

Two cyclopropane derivatives of N@C60 are synthesized by well‐controlled Bingel reactions, in which 94% of the spin centres are retained, as confirmed by a series of quantitative electron spin paramagnetic resonance measurements.
ChemInform Abstract: The Enantioselective Construction of Tetracyclic Diterpene Skeletons with Friedel—Crafts Alkylation and Palladium‐Catalyzed Cycloalkenylation Reactions.
Authors: Burke Sarah J. , Malachowski William P. , Mehta Sharan K. , Appenteng Roselyn
Published: June 2015

Tricarbocyclic products (II) are obtained by an extension of the enantioselective Birch‐Cope sequence with Friedel‐Crafts alkylation reactions.
ChemInform Abstract: Direct Generation of Oxygen‐Stabilized Radicals by H· Transfer from Transition Metal Hydrides.
Authors: Kuo Jonathan L. , Hartung John , Han Arthur , Norton Jack R.
Published: June 2015

The transition‐metal hydride HV(CO)4dppe containing a weak M—H bond is applied to convert enol ethers to α‐alkoxy radicals, which undergo cyclizations with high diastereoselectivities.
ChemInform Abstract: Nickel—NHC‐Catalyzed Cross‐Coupling of 2‐Methylsulfanylbenzofurans with Alkyl Grignard Reagents.
Authors: Baralle Alexandre , Otsuka Shinya , Guerin Vincent , Murakami Kei , Yorimitsu Hideki , Osuka Atsuhiro
Published: June 2015

The efficient method is applied in the synthesis of protein tyrosine phosphatase inhibitors of type (VI).
ChemInform Abstract: Copper‐Catalyzed Asymmetric Oxidative Cross‐Coupling of 2‐Naphthols with Aryl Methyl Ketones.
Authors: Deng Tao , Wang Hongjun , Cai Chun
Published: June 2015

The facile protocol uses the oxygen in air as the oxidant and gives enantioenriched naphthofuranones with up to 87% ee.
ChemInform Abstract: Domino [4 + 1]‐Annulation of α,β‐Unsaturated δ‐Amino Esters with Rh(II)—Carbenoids — A New Approach Towards Multi‐Functionalized N‐Aryl Pyrrolidines.
Authors: Medvedev J. J. , Galkina O. S. , Klinkova A. A. , Giera D. S. , Hennig L. , Schneider C. , Nikolaev V. A.
Published: June 2015

Multi‐functionalized pyrrolidines are obtained by catalytic decomposition of diazomalonates and other diazoesters using Rh(II)‐complexes in the presence of α,β‐unsaturate δ‐(N‐aryl)aminoesters.
ChemInform Abstract: Chiral Broensted Acid Catalyzed Intermolecular Friedel—Crafts Alkylation of Styrenes with Indoles: Construction of All‐Carbon Quaternary Stereocenters.
Authors: Li Ming‐Li , Chen Dian‐Feng , Luo Shi‐Wei , Wu Xiang
Published: June 2015

A breakthrough in asymmetric Friedel‐Crafts reactions is achieved by using terminal 1,1‐diarylalkenes as alkylating reagents, which avoids the generation of side products.
ChemInform Abstract: Copper‐Catalyzed Synthesis of N‐Aryl and N‐Sulfonyl Indoles from 2‐Vinylanilines with O2 as Terminal Oxidant and TEMPO as Cocatalyst.
Authors: Liwosz Timothy W. , Chemler Sherry R.
Published: June 2015

Whereas N‐aryl and N‐sulfonyl 2‐vinyl aniline derivatives form the desired products in moderate to high yields, primary and N‐alkyl 2‐vinyl aniline analogues are unreactive.
ChemInform Abstract: Multi‐Site Cyclization via Initial C—H Activation Using a Rhodium(III) Catalyst: Rapid Assembly of Frameworks Containing Indoles and Indolines.
Authors: Huang Ji‐Rong , Qin Liu , Zhu Yu‐Qin , Song Qiang , Dong Lin
Published: June 2015

The Rh‐catalyzed cyclization of indolinones (I) with symmetrical alkynes (II) leads to pseudo‐indoxyls (III) in moderate to high yields.
ChemInform Abstract: Experimental and Computational Study of the Catalytic Asymmetric 4π‐Electrocyclization of N‐Heterocycles.
Authors: Raja Sadiya , Nakajima Masaki , Rueping Magnus
Published: June 2015

A catalytic asymmetric Nazarov cyclization of indole derivatives to cyclopenta[b]indoles is presented.
ChemInform Abstract: Facile Synthesis of 11‐Aryl‐6H‐isoindolo[2,1‐a]indol‐6‐ones via Hypervalent Iodine(III)‐Promoted Cascade Cyclization.
Authors: Dev Kapil , Maurya Rakesh
Published: June 2015

The title tetracyclic ring systems are efficiently obtained by regio‐ and chemoselective intramolecular cascade oxidative cyclization of various 2‐(1‐arylethynyl)benzamides under metal‐free reaction conditions.
ChemInform Abstract: Copper(II)‐Catalyzed Enantioselective Intramolecular Cyclization of N‐Alkenylureas.
Authors: Fu Shaomin , Yang Honghao , Li Guoqiang , Deng Yuanfu , Jiang Huanfeng , Zeng Wei
Published: June 2015

The first example of Cu(II)‐catalyzed asymmetric intramolecular cyclization of N‐alkenylureas is developed which provides a useful method for the rapid assembly of chiral vicinal diamino bicyclic heterocycles in good yields and high enantioselectivity.
ChemInform Abstract: Enantioselective Addition of Oxazolones to N‐Protected Imines Catalyzed by Chiral Thioureas.
Authors: Zabka Matej , Malastova Andrea , Sebesta Radovan
Published: June 2015

The hydrogen bond catalyzed aza‐Mannich addition of oxazolones to a wide range of protected aldimines using bifunctional thiourea catalysts is presented.
ChemInform Abstract: Large‐Scale Continuous Flow Transformation of Oximes into Fused‐Bicyclic Isoxazolidines: An Example of Process Intensification.
Authors: Rincon Juan A. , Mateos Carlos , Garcia‐Losada Pablo , Mergott Dustin J.
Published: June 2015

Bicyclic isoxazolidines are efficiently obtained by a continuous flow protocol via [3+2] cycloaddition of in situ formed nitrones obtained from oximes.
ChemInform Abstract: A New Multicomponent Reaction: Unexpected Formation of Derivatizable Cyclic α‐Alkoxy Isothioureas.
Authors: Brockmeyer Fabian , Morosow Valentin , Martens Juergen
Published: June 2015

The reaction of thiazoline S‐monoxides with isonitriles gives cyclic α‐alkoxy isothioureas.
ChemInform Abstract: Microwave Synthesis of 5‐Substituted 1H‐Tetrazoles Catalyzed by Bismuth Chloride in Water.
Authors: Coca Adiel , Feinn Liana , Dudley Joshua
Published: June 2015

Bismuth chloride is shown to be an effective catalyst for the [2+3] cycloaddition between various nitriles (aromatic, aliphatic, vinyl) and sodium azide under microwave irradiation and optimized reaction conditions.
ChemInform Abstract: Enantioselective Michael Addition of Water.
Authors: Chen Bi‐Shuang , Resch Verena , Otten Linda G. , Hanefeld Ulf
Published: June 2015

to unsaturated lactones and ketones using whole cells of a Rhodococcus strain
ChemInform Abstract: Secondary Amine Based Ionic Liquid: An Efficient Catalyst for Solvent Free One Pot Synthesis of Xanthenes and Benzoxanthenes.
Authors: Das Pranab J. , Das Jupitara
Published: June 2015

Among three ionic liquids tested, propylammoniumhydrogensulfate is found to be the most efficient promoter for the synthesis of title compounds (III), (V), and (VI).
ChemInform Abstract: 3,5‐Disubstituted 2‐Aminopyridines via Nickel‐Catalyzed Cycloaddition of Terminal Alkynes and Cyanamides.
Authors: Zhong Yao , Spahn Nathan A. , Stolley Ryan M. , Nguyen Minh H. , Louie Janis
Published: June 2015

In addition to 3,5‐disubstituted 2‐aminopyridines the 4,6‐substituted isomers are isolated in trace to significant amounts.
ChemInform Abstract: Aza‐Annulation of Enynyl Azides: A New Approach to Substituted Pyridines.
Authors: Raji Reddy Chada , Panda Sujatarani A. , Reddy Motatipally Damoder
Published: June 2015

A novel aza‐annulation of 2‐en‐4‐ynyl azides, derived from MBH‐acetates of acetylenic aldehydes, to synthesized substituted pyridines is developed.
ChemInform Abstract: Synthesis of Heteroarylogous 1H‐Indole‐3‐carboxamidines via a Three‐Component Interrupted Ugi Reaction.
Authors: La Spisa Fabio , Meneghetti Fiorella , Pozzi Beatrice , Tron Gian Cesare
Published: June 2015

The novel one‐pot multicomponent reaction is based on the reaction of N‐alkyl‐N‐(1H‐indol‐2‐ylmethyl)amines, with various carbonyl compounds, such as aldehydes including formaldehyde or cyclohexenone, and variously functionalized isocyanides.
ChemInform Abstract: Silver Catalyzed Decarboxylative Alkylation and Acylation of Pyrimidines in Aqueous Media.
Authors: Mai Wen‐Peng , Sun Bin , You Li‐Qin , Yang Liang‐Ru , Mao Pu , Yuan Jin‐Wei , Xiao Yong‐Mei , Qu Ling‐Bo
Published: June 2015

4‐Alkylated pyrimidines or acylated pyrimidines are efficiently obtained using aliphatic carboxylic acids or 2‐oxocarboxylic acids as substrates and silver salt as catalyst under mild conditions.
ChemInform Abstract: An “All‐Water” Strategy for Regiocontrolled Synthesis of 2‐Aryl Quinoxalines.
Authors: Tanwar Babita , Purohit Priyank , Raju Banothu Naga , Kumar Dinesh , Kommi Damodara N. , Chakraborti Asit K.
Published: June 2015

Optimum reaction conditions for the one‐pot two‐step synthesis of 2‐aryl quinoxalines in aqueous medium are studied.
ChemInform Abstract: Copper‐Catalyzed Ring Expansion of 2‐Aminobenzothiazoles with Alkynyl Carboxylic Acids to 1,4‐Benzothiazines.
Authors: Qiu Jing‐Wen , Hu Bo‐Lun , Zhang Xing‐Guo , Tang Ri‐Yuan , Zhong Ping , Li Jin‐Heng
Published: June 2015

A one‐pot synthesis of the title compounds (III) is presented via decarboxylative coupling, nucleophilic ring‐opening reaction, and an intramolecular hydroamination process.
ChemInform Abstract: Nucleophile‐Dependent Diastereoselectivity in the Ring Expansion of Pyrimidines to Give 1,3‐Diazepines.
Authors: Fesenko Anastasia A. , Trafimova Ludmila A. , Albov Dmitry V. , Shutalev Anatoly D.
Published: June 2015

The conversion of pyrimidine (I) into 1,3‐diazepines involves the stereoselective addition of a nucleophile to a bicyclic cyclopropane intermediate to give cis or trans substituted products.
ChemInform Abstract: Regioselective Electrophilic Borylation of Haloarenes.
Authors: Del Grosso Alessandro , Ayuso Carrillo Josue , Ingleson Michael J.
Published: June 2015

Haloarenes undergo direct borylation using a mixture of amine, BCl3, and AlCl3 (1:1:2).
ChemInform Abstract: A New Approach to the Synthesis of 4‐Phosphonylated β‐Lactams.
Authors: Piotrowska Dorota G. , Bujnowicz Aneta , Wroblewski Andrzej E. , Glowacka Iwona E.
Published: June 2015

A Kinugasa reaction between phosphonylated nitrones and terminal alkynes leads to the title compounds as mixtures of only partially separable diastereomers.
ChemInform Abstract: Two New Labdane‐Type Diterpene Acids from the Wood of Cunninghamia konishii
Authors: Chang Chi‐I , Li Yen‐Cheng , Yang Chang‐Syan , Chao Che‐Yi , Li Yi‐Jen , Chang Hsun‐Shuo , Huang Ching‐Jeng , Kuo Ching‐Chuan , Kuo Yueh‐Hsiung
Published: June 2015

isolation and structure elucidation
ChemInform Abstract: Practical Synthesis of ε‐Carotene.
Authors: Wu Chunlei , Cao Ruiwei , Song Xiaohua , Lv Chunlei , Ye Weidong , Pi Shiqing , Chen Chaohui , Shen Runpu
Published: June 2015

The developed route is supposed to be useful for a large‐scale preparation of the title compound.
ChemInform Abstract: One‐Step Protecting‐Group‐Free Synthesis of Azepinomycin in Water.
Authors: Coggins Adam J. , Tocher Derek A. , Powner Matthew W.
Published: June 2015

A direct synthesis of the title compound (III) is achieved by the uncatalyzed reaction of 5‐aminoimidazole‐4‐carboxamide (I) with glycolaldehyde dimer in buffered aqueous solution.
ChemInform Abstract: Hydrothermal Synthesis of N‐Acetyl‐L‐Cysteine‐Capped CuInS2 Nanoparticles.
Authors: Bu Hang‐Beom , Yokota Hiroki , Shimura Kunio , Takahasi Kohji , Taniguchi Taichi , Kim DaeGwi
Published: June 2015

The title nanoparticles are hydrothermally prepared from aqueous mixtures of N‐acetyl‐L‐cysteine, CuCl2, InCl3, and Na2S (autoclave, 180 °C, 5—20 min).
ChemInform Abstract: Enantioselective Titanium‐Promoted 1,2‐Additions of Carbon Nucleophiles to Carbonyl Compounds
Authors: Pellissier Helene
Published: June 2015

Review: 131 refs.
ChemInform Abstract: Z‐Selective Cross Metathesis with Ruthenium Catalysts: Synthetic Applications and Mechanistic Implications
Authors: Herbert Myles B. , Grubbs Robert H.
Published: June 2015

Review: [20 refs.
ChemInform Abstract: A Unified Survey of Si—H and H—H Bond Activation Catalyzed by Electron‐Deficient Boranes
Authors: Oestreich Martin , Hermeke Julia , Mohr Jens
Published: June 2015

Review: [84 refs.
ChemInform Abstract: Accessible Syntheses of Late Transition Metal (Pre)Catalysts Bearing N‐Heterocyclic Carbene Ligands
Authors: Nelson David J.
Published: June 2015

Review: 132 refs.
ChemInform Abstract: Cyclic Hypervalent Iodine Reagents and Iron Catalysts: The Winning Team for Late‐Stage C—H Azidation
Authors: Vita Maria Victoria , Waser Jerome
Published: June 2015

Review: 13 refs.
ChemInform Abstract: Lithium Chloride Carbenoids in Bond Activation Reactions
Authors: Molitor Sebastian , Gessner Viktoria H.
Published: June 2015

Review: [38 refs.
ChemInform Abstract: Conformational Properties of Aromatic Multi‐Layered and Helical Oligoureas and Oligoguanidines
Authors: Kudo Mayumi , Tanatani Aya
Published: June 2015

Review: [16 refs.
ChemInform Abstract: The Electronic Structure Calculations of Two‐Dimensional Transition‐Metal Dichalcogenides in the Presence of External Electric and Magnetic Fields
Authors: Kuc Agnieszka , Heine Thomas
Published: June 2015

Review: 50 refs.
ChemInform Abstract: Phonon and Raman Scattering of Two‐Dimensional Transition Metal Dichalcogenides from Monolayer, Multilayer to Bulk Material
Authors: Zhang Xin , Qiao Xiao‐Fen , Shi Wei , Wu Jiang‐Bin , Jiang De‐Sheng , Tan Ping‐Heng
Published: June 2015

Review: 195 refs.
ChemInform Abstract: Walther Nernst and the Development of Physical Chemistry
Authors: Ertl Gerhard
Published: June 2015

Review: 28 refs.
ChemInform Abstract: Ruthenium Complexes as Antimicrobial Agents
Authors: Li Fangfei , Collins J. Grant , Keene F. Richard
Published: June 2015

Review: 112 refs.
ChemInform Abstract: Two‐Dimensional Graphene Analogues for Biomedical Applications
Authors: Chen Yu , Tan Chaoliang , Zhang Hua , Wang Lianzhou
Published: June 2015

Review: 192 refs.
ChemInform Abstract: Enzyme Immunoassays as Screening Tools for Catalysts and Reaction Discovery
Authors: Creminon Christophe , Taran Frederic
Published: June 2015

Review: [59 refs.
ChemInform Abstract: Recent Progress on Pyrazole Scaffold‐Based Antimycobacterial Agents
Authors: Keri Rangappa S. , Chand Karam , Ramakrishnappa Thippeswamy , Nagaraja Bhari Mallanna
Published: June 2015

Review: [98 refs.
ChemInform Abstract: Titania Nanostructures: A Biomedical Perspective
Authors: Damodaran Vinod B. , Bhatnagar Divya , Leszczak Victoria , Popat Ketul C.
Published: June 2015

Review: 213 refs.
ChemInform Abstract: Semi‐Synthesis of Thioamide Containing Proteins
Authors: Wang Yanxin J. , Szantai‐Kis D. Miklos , Petersson E. James
Published: June 2015

Review: [78 refs.
ChemInform Abstract: Magnesium‐Based Systems for Carbon Dioxide Capture, Storage and Recycling: From Leaves to Synthetic Nanostructured Materials
Authors: Vitillo Jenny G.
Published: June 2015

Review: 315 refs.
ChemInform Abstract: Catalytic Total Hydrodeoxygenation of Biomass‐Derived Polyfunctionalized Substrates to Alkanes
Authors: Nakagawa Yoshinao , Liu Sibao , Tamura Masazumi , Tomishige Keiichi
Published: June 2015

Review: [59 refs.
ChemInform Abstract: Current Technologies, Economics, and Perspectives for 2,5‐Dimethylfuran Production from Biomass‐Derived Intermediates
Authors: Saha Basudeb , Abu‐Omar Mahdi M.
Published: June 2015

Review: [71 refs.
ChemInform Abstract: A Critical Review on in situ Reduction of Graphene Oxide During Preparation of Conducting Polymeric Nanocomposites
Authors: Mural Prasanna Kumar S. , Sharma Maya , Madras Giridhar , Bose Suryasarathi
Published: June 2015

Review: 52 refs.
ChemInform Abstract: A Critical View on Catalytic Pyrolysis of Biomass
Authors: Venderbosch R. H.
Published: June 2015

Review: [41 refs.
ChemInform Abstract: Non‐volatile Resistive Memory Devices Based on Solution‐Processed Ultrathin Two‐Dimensional Nanomaterials
Authors: Tan Chaoliang , Liu Zhengdong , Huang Wei , Zhang Hua
Published: June 2015

Review: 50 refs.
ChemInform Abstract: Computational Approaches to Understanding Reaction Outcomes of Organic Processes in Ionic Liquids
Authors: Keaveney Sinead T. , Harper Jason B. , Croft Anna K.
Published: June 2015

Review: 292 refs.
ChemInform Abstract: Recent Advances in Electrochemical Detection of Toxic Cr(VI)
Authors: Jin Wei , Yan Kai
Published: June 2015

Review: 84 refs.
Enhanced γ‐H2AX DNA damage foci detection using multimagnification and extended depth of field in imaging flow cytometry
Authors: Parris Christopher N. , Adam Zahir Sheba , Al‐Ali Hussein , Bourton Emma C. , Plowman Christina , Plowman Piers N.
Published: June 2015

Accurate and rapid methods for the detection of DNA damage foci in eukaryotic cells are central to DNA repair studies, which identify differences in DNA repair capacity in cell lines. Such assays have been important in delineating mechanisms of DNA repair in human cells. Previously we were the first to demonstrate the use of imaging flow cytometry for the detection of γ‐H2AX foci in cells exposed to ionizing radiation causing the induction of DNA strand breaks. In this report we extend these studies and show an enhancement of foci quantitation and image resolution using next generation imaging flow cytometry with the Amnis ImagestreamX Mark II. We demonstrate using cell lines derived from normal individuals, and DNA double strand break repair defective cells that the number of foci observed is significantly increased when using 60× as compared to 40× magnification. Also, foci numbers and resolution is further increased with the application of the focus stacking (Extended Depth of Field–EDF) capacity activated. This report represents the first such demonstration of multimagnification and EDF for the enhanced quantitation of DNA damage in cells and provides a level of resolution, which near matches in situ microscopy methods for the detection of γ‐H2AX foci. © 2015 The Authors. Published by Wiley Periodicals Inc. on behalf of ISAC.
Effect of Pulse Width of Square Potential to Remove Silver Interference in the Determination of Mercury(II)
Authors: Farahi A. , Achak M. , El Gaini L. , El Yamani S. , Bakasse M. , El Mhammedi M. A.
Published: June 2015

A graphite electrode modified with silver (Ag‐CPE) has been applied to detect mercury(II) using differential pulse voltammetry (DPV). Under optimized conditions, the calibration curve is linear in the range from 5.0×10−8 mol L−1 to 1.0×10−4 mol L−1 of mercury(II). The detection limit was found to be 3.38×10−8 mol L−1 with a relative standard deviation (RSD) of 2.25 % (n=8). The proposed method was successfully applied for the detection of mercury(II) in leachate samples. The Ag‐CP composites were characterized using X‐ray diffraction (XRD), BET adsorption analysis and scanning electron microscopy (SEM).
Electrochemical Determination of Uric Acid, Dopamine and Tryptophan at Zinc Hexacyanoferrate Clay Modified Electrode
Authors: Kemmegne‐Mbouguen Justin Claude , Angnes Lúcio , Mouafo‐Tchinda Edwige , Ngameni Emmanuel
Published: June 2015

A Cameroonian smectite clay has been transformed into Zn2+ homoionic form and then used to prepare film modified glassy carbon electrodes and carbon paste electrodes. These electrodes containing Zn2+ were exploited to prepare a mixed valence zinc hexacyanoferrate (ZnHCF). Cyclic voltammetry has been employed to monitor the in situ growth of ZnHCF on clay modified electrodes. Although interesting electrocatalytic properties toward UA were observed with these modified electrodes, the modified carbon paste electrodes were the most suitable for dopamine, uric acid and tryptophan detection and exhibited for these analytes extended linear range, high sensitivities, selectivity and low limit.
The toxic effects of Bisphenol A on the mouse spermatocyte GC‐2 cell line: the role of the Ca2+‐calmodulin‐Ca2+/calmodulin‐dependent protein kinase II axis
Authors: Qian Wenyi , Wang Yixin , Zhu Jingying , Mao Changfei , Wang Qiang , Huan Fei , Cheng Jie , Liu Yanqing , Wang Jun , Xiao Hang
Published: June 2015

Bisphenol A (BPA), an endocrine‐disrupting chemical (EDC), is known to induce male reproductive toxicity in rodents. However, its toxic effects on the germ cells are still poorly understood. It has been proposed that Ca2+ homeostasis and Ca2+ sensors, including calmodulin (CaM) and calmodulin‐dependent protein kinase II (CaMKII), play critical roles in spermatogenesis. Therefore, in the present study, we aimed to investigate whether a perturbation in Ca2+‐CaM‐CaMKII signaling was involved in the BPA‐induced injury to mouse spermatocyte GC‐2spd (ts) (GC‐2) cells. Our results showed that BPA (range from 0.2 to 20 μM) induced obvious GC‐2 cell injury, including decreased cell viability, the release of mitochondrial cytochrome c and the activation of caspase‐3. However, these processes could be partially abrogated by pretreatment with a Ca2+ chelator (BAPTA/AM), a CaM antagonist (W7) or a CaMKII inhibitor (KN93). These results, taken together, indicate that BPA exposure contributes to male germ cell injury, which may be partially mediated through a perturbation in Ca2+/CaM/CaMKII signaling and the mitochondrial apoptotic process. Copyright © 2015 John Wiley & Sons, Ltd.
Percutaneous transhepatic portal vein stenting for malignant portal vein stenosis secondary to recurrent perihilar biliary cancer
Authors: Mizuno Takashi , Ebata Tomoki , Yokoyama Yukihiro , Igami Tsuyoshi , Sugawara Gen , Mori Yoshine , Suzuki Kojiro , Nagino Masato
Published: June 2015

Background

Transhepatic portal vein (PV) stenting has been shown to be one of the most important treatments for patients with PV stenosis caused by hepatopancreatobiliary malignancy.

Methods

Ten consecutive patients with PV stenosis caused by the recurrence of a perihilar biliary malignancy underwent transhepatic PV stenting. A self‐expandable metallic stent was deployed at the stenosis site. The patients were retrospectively analyzed with regard to the procedure, complications, and survival after the stent placement.

Results

The median interval between the primary resection and the PV stenting was 22 months. The initial hepatic resection was a left trisectionectomy with caudate lobectomy in seven patients, a left hepatectomy with caudate lobectomy in one patient, a right anterior sectionectomy with caudate lobectomy following a left hepatectomy in one patient and a partial liver resection in one patient. The angle of the PV around the stenosis was greater in the patients with PV stenosis located in the right posterior PV. Eight patients with successful PV stent placement were able to receive anticancer treatment, with a median survival of 14 months. The remaining two patients without successful PV stent placement survived less than 6 months.

Conclusions

Portal vein stenting might offer relief from the symptoms associated with PV hypertension and the opportunity for sustainable anticancer therapy in patients with recurrent perihilar biliary malignancy.