bluuebunny/crossref_metadata_2025 huggingface dataset:
Coffee Oil Extraction Methods: A Review
Authors: Ribeiro Raquel C. , Mota Maria Fernanda S. , Silva Rodrigo M. V. , Silva Diana C. , Novaes Fabio J. M. , da Veiga Valdir F. , Bizzo Humberto R. , Teixeira Ricardo S. S. , Rezende Claudia M.
Published: August 2024

Green and roasted coffee oils are products rich in bioactive compounds, such as linoleic acid and the diterpenes cafestol and kahweol, being a potential ingredient for food and cosmetic industries. An overview of oil extraction techniques most applied for coffee beans and their influence on the oil composition is presented. Both green and roasted coffee oil extractions are highlighted. Pressing, Soxhlet, microwave, and supercritical fluid extraction were the most used techniques used for coffee oil extraction. Conventional Soxhlet is most used on a lab scale, while pressing is most used in industry. Supercritical fluid extraction has also been evaluated mainly due to the environmental approach. One of the highlighted activities in Brazilian agribusiness is the industrialization of oils due to their increasing use in the formulation of cosmetics, pharmaceuticals, and foods. Green coffee oil (raw bean) has desirable bioactive compounds, increasing the interest of private companies and research institutions in its extraction process to preserve the properties contained in the oils.
Exploring Volatile Profiles and De-Flavoring Strategies for Enhanced Acceptance of Lentil-Based Foods: A Review
Authors: Vurro Francesca , De Angelis Davide , Squeo Giacomo , Caponio Francesco , Summo Carmine , Pasqualone Antonella
Published: August 2024

Lentils are marketed as dry seeds, fresh sprouts, flours, protein isolates, and concentrates used as ingredients in many traditional and innovative food products, including dairy and meat analogs. Appreciated for their nutritional and health benefits, lentil ingredients and food products may be affected by off-flavor notes described as “beany”, “green”, and “grassy”, which can limit consumer acceptance. This narrative review delves into the volatile profiles of lentil ingredients and possible de-flavoring strategies, focusing on their effectiveness. Assuming that appropriate storage and processing are conducted, so as to prevent or limit undesired oxidative phenomena, several treatments are available: thermal (pre-cooking, roasting, and drying), non-thermal (high-pressure processing, alcohol washing, pH variation, and addition of adsorbents), and biotechnological (germination and fermentation), all of which are able to reduce the beany flavor. It appears that lentil is less studied than other legumes and more research should be conducted. Innovative technologies with great potential, such as high-pressure processing or the use of adsorbents, have been not been explored in detail or are still totally unexplored for lentil. In parallel, the development of lentil varieties with a low LOX and lipid content, as is currently in progress for soybean and pea, would significantly reduce off-flavor notes.
15 December 1929, “Tying Trees at Robinzon’s”; 16 December 1929, “Unemployed”—A Work Diary (1928–1931) of a Jewish Agricultural Laborer in the Establishment of the Citrus Orchards in Eretz Israel
Authors: Hershkovitz Arnon
Published: August 2024

This article presents a detailed analysis of a unique item from the author’s family archive: the work diary of his grandfather, Mordechai Livnat (Libman). In this diary, Livnat meticulously recorded, between 1928 and 1931, the details of his work as an agricultural laborer in Herzliya—at the time, a small village in the central part of Eretz Israel (aka pre-State Israel)—primarily during the establishment of the new colony’s citrus orchards. The diary documents employment details, employer information, working hours, and wages received. Quantitative and qualitative analyses of the information contained in the diary paint a comprehensive picture that allows us to learn about the lives of Jewish agricultural laborers in Eretz Israel at that time. In particular, the hardships faced by these workers stand out, primarily job insecurity, which manifested mainly in their dependence on the weather and the need to work for multiple employers. This article also sheds light on aspects related to agricultural work before the introduction of technological advancements to the agricultural sector, which was mainly manual then, and its impact on the daily routine of the agricultural laborer. The diary is analyzed using an inductive approach—from the text outwards—in a way that emphasizes the complexity and importance of the connections between the macro and micro in historical research. This way, it is demonstrated how items collected during genealogy research can shed important light on historical knowledge, and not just the other way around.
Effect of Tai Chi Compared to Running on Drug Cravings, Attention Bias, and Physical Fitness in Men with Methamphetamine Use Disorder
Authors: Zhang Ling , Zeng Haiqi , Sun Yuliang , Xue Huiheng , Gao Liquan , Zhu Wenfei
Published: August 2024

Background: Methamphetamine use disorder (MUD) is a global health problem. Studies have shown Tai Chi is a potential treatment for MUD. We aimed to explore the effectiveness of Tai Chi in improving drug cravings, attention bias, and physical fitness in men with MUD compared with aerobic exercise. Methods: A total of forty-eight participants (mean age 39.1 ± 8.7 years) were randomly assigned to either the Tai Chi group (TC) or the running group (RG). The TC performed 60 min of moderate-intensity (65–75% HRmax) Tai Chi exercise three times a week. The RG performed 60 min of moderate-intensity (65–75% HRmax) running on a treadmill three times a week. Before and after the intervention, drug cravings, attention bias, and physical fitness were evaluated. Results: After 12 weeks, we found the TC significantly improved in attention bias (F (1, 43) = 6.023, p = 0.019, d = −0.42) and reaction time (F (1, 43) = 6.181, p = 0.017, d = −0.72). No significant improvement was found in other variables in the TC, compared to the RG (p > 0.05). Conclusions: The 12-week Tai Chi intervention improved attention bias and reaction time, compared to RG. Tai Chi exercise might be a potential auxiliary method for the rehabilitation for men with MUD.
Determining the Best Noninvasive Test for Peripheral Arterial Disease Diagnosis to Predict Diabetic Foot Ulcer Healing in Patients Following Endovascular Revascularization
Authors: Álvaro-Afonso Francisco Javier , García-Álvarez Yolanda , García-Morales Esther Alicia , Flores-Escobar Sebastián , De Benito-Fernández Luis , Alfayate-García Jesús , Sánchez-Ríos Juan Pedro , Puras-Mallagray Enrique , Malo-Benages Esteban Javier , Ramírez-Ortega Marta , Redondo-López Sandra , Cecilia-Matilla Almudena , Lázaro-Martínez José Luis
Published: August 2024

Background/Objectives: To analyze the best noninvasive tests prognosis marker in patients with diabetic foot ulcer (DFU) who underwent endovascular revascularization based on clinical outcomes, such as healing rate, time to heal, and free amputation survival after at least a six-month follow-up. Methods: A multicentric prospective observational study was performed with 28 participants with ischemic or neuroischemic DFU who came to the participant centers and underwent endovascular revascularization between January 2022 and March 2023. Toe systolic pressure (TP), ankle systolic pressure (AP), the ankle brachial pressure index (ABPI), the toe brachial pressure index (TBPI), transcutaneous pressure of oxygen (TcPO2), and skin perfusion pressure (SPP) were evaluated using PeriFlux 6000 System, Perimed, Sweden, before (Visit 0) and four weeks after revascularization (Visit 1). The primary clinical outcome was an evaluation of the clinical evolution of noninvasive tests comparing Visit 0 and Visit 1, estimating the sensitivity for predicting wound healing of noninvasive tests at six months following initial recruitment. Results: After six months, 71.43% (n = 20) of DFU healed, four patients (14.3%) received major amputations, and one (3.5%) died. The two tests that best predicted wound healing after revascularization according to the ROC curve were TcPO2 and TP with sensitivities of 0.89 and 0.70 for the cut-off points of 24 mmHg and 46 mmHg, respectively. Conclusions: TcPO2 and TP were the two tests that best predicted wound healing in patients who underwent endovascular revascularization. Clinicians should consider the importance of the evaluation of microcirculation in the healing prognosis of patients with diabetic foot ulcers.
Phenotypic and Molecular-Markers-Based Assessment of Jamun (Syzygium cumini) Genotypes from Pakistan
Authors: Uddin Safeer , Jaskani Muhammad , Deng Zhanao , Maqbool Rizwana , Naqvi Summar , Parajuli Saroj , Sharif Naseem , Saleem Abdul , Ledon Steven , Ikram Sufian , Khan Iqrar , Shafqat Waqar
Published: August 2024

Jamun plant displays enormous diversity throughout Pakistan, which necessitates its screening, evaluation, and validation to document elite genotypes having better traits for the benefit of the fruit industry and farmers. Surveys were made in natural Jamun habitats across Punjab, Pakistan, and genotypes were marked based on visual diversity of trees and fruits. In total, 60 Jamun genotypes were selected for characterization based on phenotypic and genetic markers. Phenotypic characters related to trees, leaf, and flower along with fruit qualitative traits were assessed in situ. Results revealed significant diversity with high (>25%) coefficient of variance values and the first two components of correspondence analysis exhibited 41.71% variation among genotypes. A strong association was observed among traits like upright tree and round fruit shape (0.74), bluish-colored fruit and pinkish pulp (0.85), and elliptic-shaped fruit with low fruit waxiness (−0.72). Leaves of phenotypically characterized plants were brought to Wheat Biotechnology Lab., University of Agriculture, Faisalabad, Pakistan, where Jamun genotypes were investigated genetically using Random Amplified Polymorphic DNA (RAPD) and Inter Simple Sequence Repeat (ISSR) markers. A total of 132 bands were scored, of which 108 were polymorphic, corresponding to almost 81% polymorphism among collected genotypes. High polymorphism information content values were observed against RAPD (0.389) and ISSR (0.457) markers. Genotypes were compared in relation to genetic markers, which exhibited that almost 86% of genetic variability was attributed to differences among accessions, while 14% of variation was due to differences between collections of different areas. Findings of this study confirmed wide phenotypic and genetic distinctness of Jamun in Pakistan that can aid breeders for marker-assisted selection and germplasm enhancement for future crop improvement programs.
Genetic Programming to Optimize 3D Trajectories
Authors: Kotze André , Hildemann Moritz Jan , Santos Vítor , Granell Carlos
Published: August 2024

Trajectory optimization is a method of finding the optimal route connecting a start and end point. The suitability of a trajectory depends on not intersecting any obstacles, as well as predefined performance metrics. In the context of unmanned aerial vehicles (UAVs), the goal is to minimize the route cost, in terms of energy or time, while avoiding restricted flight zones. Artificial intelligence techniques, including evolutionary computation, have been applied to trajectory optimization with varying degrees of success. This work explores the use of genetic programming (GP) for 3D trajectory optimization by developing a novel GP algorithm to optimize trajectories in a 3D space by encoding 3D geographic trajectories as function trees. The effects of parameterization are also explored and discussed, demonstrating the advantages and drawbacks of custom parameter settings along with additional evolutionary computational techniques. The results demonstrate the effectiveness of the proposed algorithm, which outperforms existing methods in terms of speed, automaticity, and robustness, highlighting the potential for GP-based algorithms to be applied to other complex optimization problems in science and engineering.
Nitrate Reductase and Glutamine Synthetase Enzyme Activities and Chlorophyll in Sorghum Leaves (Sorghum bicolor) in Response to Organic Fertilization
Authors: Nieves-Silva Ericka , Sandoval-Castro Engelberto , Delgado-Alvarado Adriana , Castañeda-Antonio María D. , Huerta-De la Peña Arturo
Published: August 2024

Sorghum is a plant that mainly requires chemical nitrogen fertilization. There are organic fertilizers that can provide nutrients to plants with great benefits to the soil, such as chicken manure. To determine the influence of organic fertilization on nitrate reductase (NR), glutamine synthetase (GS), and the amount of chlorophyll, sorghum plants were grown using the following four treatments: soil (T1), soil + chicken manure 100 kg ha−1 of nitrogen (N) (T2), soil + chicken manure 200 kg ha−1 N (T3), and soil + ammonium sulfate 100 kg ha−1 N (T4). Leaves were sampled in the vegetative stage (VS), the reproductive stage (RS), and the maturation stage (MS). The highest NR activity occurred in plants with T2 and T3 in the VS. The highest GS activity was in T3 and T4 in the RS. The amount of chlorophyll a was the same in all phenological stages. However, the amount of chlorophyll b was influenced by the type of fertilization at different phenological stages. Organic fertilizers (OF) produced the highest NR activity. On the other hand, GS activity was higher with chemical fertilization (T4), which was equal to the second dose of organic fertilization (T3). Finally, chlorophyll a and b were influenced by both types of fertilization, and was different from T1.
Bridging Linguistic Gaps: Developing a Greek Text Simplification Dataset
Authors: Agathos Leonidas , Avgoustis Andreas , Kryelesi Xristiana , Makridou Aikaterini , Tzanis Ilias , Mouratidis Despoina , Kermanidis Katia Lida , Kanavos Andreas
Published: August 2024

Text simplification is crucial in bridging the comprehension gap in today’s information-rich environment. Despite advancements in English text simplification, languages with intricate grammatical structures, such as Greek, often remain under-explored. The complexity of Greek grammar, characterized by its flexible syntactic ordering, presents unique challenges that hinder comprehension for native speakers, learners, tourists, and international students. This paper introduces a comprehensive dataset for Greek text simplification, containing over 7500 sentences across diverse topics such as history, science, and culture, tailored to address these challenges. We outline the methodology for compiling this dataset, including a collection of texts from Greek Wikipedia, their annotation with simplified versions, and the establishment of robust evaluation metrics. Additionally, the paper details the implementation of quality control measures and the application of machine learning techniques to analyze text complexity. Our experimental results demonstrate the dataset’s initial effectiveness and potential in reducing linguistic barriers and enhancing communication, with initial machine learning models showing promising directions for future improvements in classifying text complexity. The development of this dataset marks a significant step toward improving accessibility and comprehension for a broad audience of Greek speakers and learners, fostering a more inclusive society.
Raman Spectroscopy and Microstructural Characterization of Hot-Rolled Copper/Graphene Composite Materials
Authors: Bident Antoine , Grosseau-Poussard Jean-Luc , Delange Florence , Addad Ahmed , Ji Gang , Lu Yongfeng , Bobet Jean-Louis , Veillere Amélie , Silvain Jean-François
Published: August 2024

Given the increase in current density in the constituent materials of electrical systems, improving the electrical conductivity of these materials, particularly copper (Cu), is crucial. This would also help to mitigate the heat generated by Joule heating. The incorporation of graphene (Gr) into a composite material (Cu/Gr) is a viable solution. However, to ensure the proper transfer of properties between the reinforcement and the matrix, several elements must be considered, including the orientation of the reinforcement. As a 2D material, controlling graphene’s orientation within the structure is essential but often overlooked. To address this issue, hot rolling was implemented to improve the alignment of the reinforcement. The inclusion of graphene led to a 12 HV increase in the material’s hardness, demonstrating a positive composite effect. Simultaneously, rolling increased the material’s hardness from 67.6 to 75.1 HV by introducing more dislocations into the material. To characterize the graphene’s alignment, polarized Raman spectroscopy was used. This technique highlighted the improved alignment of the reinforcement in the rolling direction, a change that was visible and confirmed by scanning electron microscopy micrographs.
Screening and Characterization of a New Iflavirus Virus in the Fruit Tree Pest Pyrops candelaria
Authors: Lin Hong , Song Weitao , Ma Dongmei , Yang Chi , Yao Yanfang , Liu Renyi , Hao Ling , Wu Dandan , Wang Shihua , Jiang Jimou , Xiong Jun , Ma Rui , Xiao Jiajing , Zhuang Zhenhong
Published: August 2024

Pyrops candelaria is one of the common pests of fruit trees, but the research on the pathogenic microorganisms it may carry is very limited. Therefore, it is essential to reveal the pathogenic microbes it carries and their potential hazards. This study found a new virus from the transcriptome of P. candelaria, which was first reported in P. candelaria and named PyCaV (Pyrops candelaria associated virus). RACE and bioinformatics assay revealed that the full length of PyCaV is 10,855 bp with the polyA tail, containing a single open-reading frame (ORF) encoding a polyprotein consisting of 3171 amino acid (aa). The virus has a typical iflavirus structure, including two rhv domains, an RNA helicase domain (HEL), a 3C cysteine protease domain (Pro), and an RNA–dependent RNA polymerase domain (RdRp). Further phylogenetic analysis revealed that this virus belongs to family Iflaviridae and sequence alignments analysis suggested PyCaV is a new member in an unassigned genus of family Iflaviridae. Further in-depth analysis of the virus infection showed that PyCaV is distributed throughout the whole P. candelaria, including its head, chest, and abdomen, but more PyCaV was identified in the chest. The distribution of PyCaV in different parts of P. candelaria was further explored, which showed that more PyCaV was detected in its piercing–sucking mouthparts and chest viscera. Statistical analysis showed that the PyCaV infection was affected by time and location.
The Clinicopathological Characteristics and Surgical Treatment of Gastrointestinal Neuroendocrine Neoplasm—A 10-Year Single-Center Experience
Authors: Serafin Michał , Jabłońska Beata , Senderek Emila , Majewska Karolina , Mrowiec Sławomir
Published: August 2024

Background: Gastrointestinal neuroendocrine neoplasms (GI-NENs) represent a diverse group of tumors, with surgical resection being the gold standard for treatment. Materials and Methods: A retrospective analysis was conducted on 63 patients (32 women, 31 men) who underwent surgery for GI-NENs at the Department of Digestive Tract Surgery from January 2013 to June 2023. Tumors were classified by stage (localized, regionally advanced, metastatic). Results: Clinical symptoms were reported by 42 (66.7%) patients, with abdominal pain being the most common symptom, affecting 28 (44.4%) patients. The majority of tumors (44, 69.8%) originated in the midgut. The most frequently performed surgery was right hemicolectomy, carried out on 33 (52.4%) patients. Radical tumor resection was performed in 35 (55.6%) patients. Postoperative complications occurred in 12 (19%) patients, with male gender identified as an independent predictive factor for complications (p = 0.04). Non-functioning tumors were more common (33, 52.4%), and most tumors were classified as grade 1 histopathologically (49, 77.8%). Distant metastases were present in 29 (46%) patients. The overall two-year survival rate was 94.9%, with a five-year survival rate also estimated at 94.9%. Conclusions: GI-NENs are often diagnosed at advanced stages, frequently with distant or lymph node metastases, and predominantly arise in the midgut. Despite low postoperative morbidity and mortality, male gender may be a predictor of postoperative complications. Overall, the prognosis for GI-NENs is favorable, reflected in high overall survival rates.
Beyond Glycemic Control: GLP-1 Receptor Agonists and Their Impact on Calcium Homeostasis in Real-World Patients
Authors: Alenezi Bandar T. , Elfezzani Nadra , Uddin Rukhsana , Patel Hinali , Chester Sydney , Abdelmaksoud Ahmed , Hussein Mohammad H. , Zaitone Sawsan A. , Fawzy Manal S. , Aiash Hani , Toraih Eman A.
Published: August 2024

Background/Objectives: The effect of glucagon-like peptide-1 receptor (GLP-1R) agonists on calcium homeostasis is poorly understood. This study aimed to investigate the association between GLP-1R agonist use and the risk of hypocalcemia and/or hypercalcemia, as well as other clinical outcomes. Methods: A retrospective cohort study used de-identified patient data from the TriNetX Global Collaborative Network, including 15,655 adult patients prescribed GLP-1R agonists and 15,655 propensity-matched controls. Outcomes included hypocalcemia, hypercalcemia, emergency visits, hospitalizations, cardiovascular events, and all-cause mortality. Results: GLP-1R agonist use was associated with a reduced risk of hypocalcemia (2.7% vs. 5.5%, RR 0.49, 95% CI: 0.44–0.55) but an increased risk of hypercalcemia (2.3% vs. 1.1%, RR 2.02, 95% CI: 1.69–2.42). The effect on hypocalcemia was most pronounced during the first six months of treatment. Among individual agents, tirzepatide showed the most pronounced effect, reducing hypocalcemia risk by 63% while increasing hypercalcemia risk by 85%. Semaglutide demonstrated similar effects, while dulaglutide and liraglutide showed modest effects. Furthermore, GLP-1R agonist use was associated with reduced risks of emergency visits (RR 0.57, 95% CI: 0.54–0.60), hospitalizations (RR 0.40, 95% CI: 0.36–0.44), cardiovascular events, and all-cause mortality (HR 0.27, 95% CI: 0.21–0.36). Conclusions: GLP-1R agonists exhibit a complex influence on calcium homeostasis, reducing hypocalcemia risk while increasing hypercalcemia risk. Beyond calcium regulation, these medications significantly reduce healthcare utilization, improve cardiovascular outcomes, and decrease mortality. Further research is needed to elucidate the mechanisms behind the differential effects of individual GLP-1R agonists, particularly tirzepatide, to optimize personalized treatment approaches and long-term safety.
The Indirect Effect of Future Anxiety on the Relationship between Self-Efficacy and Depression in a Convenience Sample of Adults: Revisiting Social Cognitive Theory
Authors: Szota Marta , Rogowska Aleksandra M. , Kwaśnicka Aleksandra , Chilicka-Hebel Karolina
Published: August 2024

Background/Objectives: Depression and anxiety are prevalent disorders, particularly during emerging adulthood. Uncertainty about the future, exacerbated by unstable times, can lead to heightened future anxiety in this group. This study aimed to examine the complex associations of depression symptoms, future anxiety, and self-efficacy in adults from Poland. Additionally, we investigated age and gender differences in depression symptoms, future anxiety, and self-efficacy. Methods: A cross-sectional online survey study was performed in 2023 in Poland using snowball sampling. A convenience sample of 284 adults participated in this study, ranging in age between 18 and 65 years old (M = 32.18, SD = 11.87), including 95 men (33.45%) and 189 (66.55%) women, and also 157 (55.63%) emerging adults (18–28 years old) and 126 (44.37%) middle-aged adults (29–65 years old). The Patient Health Questionnaire (PHQ-9), Dark Future Scale (DFS-5), and Generalized Self-Efficacy Scale (GSES) were used to measure depression, future anxiety, and self-efficacy, respectively. Results: A 2-way ANOVA showed that both emerging adults and women scored significantly higher in depression symptoms and future anxiety than middle-aged adults and men, respectively. Furthermore, women scored lower in self-efficacy than men. Analyses revealed that there was a positive correlation between depression and future anxiety. Self-efficacy was negatively correlated with depression and future anxiety. Self-efficacy and future anxiety accounted for 48% of depression variance, controlling for age and gender. Future anxiety was found to be a partial mediator of the relationship between self-efficacy and depression. Conclusions: This study significantly advances the understanding of mental health in adults, grounded in social cognitive theories, revealing that low self-efficacy heightens future anxiety, thereby exacerbating depression symptoms in the Polish adult population, independent of age and gender. Emerging adults and women need psychological support to reduce depression and future anxiety. Women, in particular, should be the main focus of interventions to boost self-efficacy. Implementing targeted preventive measures and support systems can mitigate the challenges faced by emerging adults and women.
Pruritus in Lichen Planopilaris and Frontal Fibrosing Alopecia—Clinical Characteristics and Dermoscopic Correlations
Authors: Kołcz Kinga , Krawczyk-Wołoszyn Karolina , Reich Adam , Żychowska Magdalena
Published: August 2024

Background: Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are the most common causes of lymphocytic scarring alopecia. Itching of the scalp is a common accompanying symptom. The aim of the study was the clinical assessment of pruritus and its correlation with dermoscopic features. Methods: Sixty-one patients with scarring alopecia were analyzed (LPP = 16; FFA = 33; coexisting LPP-FFA = 12). Each patient underwent a trichoscopic examination. Itch severity and characteristics were assessed using a Visual Analogue Scale (VAS), 4-item Itch Questionnaire and 12-item Descriptive Pruritus Assessment Questionnaire. Results: Itching of the scalp occurred in 73.8% of the patients (mean maximal VAS 5.3 ± 3.1 points). Pruritus was most frequently accompanied by tingling (19.7%) or burning (14.8%) sensations. The following factors most frequently increased the severity of pruritus: sweating, heat, stress and hot water. On the other hand, cold water and cold air often relieved symptoms. There was a significant relationship between itch and perifollicular scaling (p = 0.011), hair diameter diversity (p = 0.008) and white halo (p = 0.016). Conclusions: Pruritus was the main subjective complaint reported by patients suffering from LPP and FFA. A better understanding of pruritic features may help in the selection of an effective therapeutic strategy.
Pallidal Versus Subthalamic Deep-Brain Stimulation for Generalized Isolated Dystonia: A Retrospective Study
Authors: Wu Jingchao , Zhu Guanyu , Gan Yifei , Meng Fangang , Yang Anchao , Zhang Jianguo
Published: August 2024

Objectives: Deep-brain stimulation (DBS) has been used for the treatment of medically refractory dystonia with excellent results. In this study, we compared in detail the therapeutic advantages of two DBS targets for generalized isolated dystonia. Methods: In this retrospective study, we recruited 29 patients with generalized isolated dystonia who had undergone DBS treatment targeting either the globus pallidus interna (GPi) or the subthalamic nucleus (STN) in the Department of Functional Neurosurgery at Tiantan Hospital, Beijing, China, between January 2016 and December 2021. The movement and disability subscales of the Burke–Fahn–Marsden dystonia rating scale (BFMDRS) were used to assess the severity of their dystonic symptoms and their activities of daily living, respectively. SF-36 was used to evaluate the patients’ health-related quality of life. Results: The percentage improvement in the BFMDRS-M score at 6 months relative to the baseline score was clearly higher in the STN group (63.91%) than in the GPi group (38.36%). At the 3-, 6-, and 12-month follow-ups, the percentage improvement in arm symptoms was significantly higher after DBS of the STN (70.64%, 80.66%, and 76.89%, respectively) than after stimulation of the GPi (36.75%, 34.21%, and 38.47%, respectively). At 12 months after surgery, patient quality of life had improved on all SF-36 subscales in both groups. Conclusions: STN-DBS may have more advantages than GPi-DBS in patients with obvious arm dystonia. STN-DBS had a better clinical effect than GPi-DBS within 6 months after surgery.
Shear Wave Elastography of the Skin following Radial Forearm Free Flap Surgery in Transgender Patients: Observational Study
Authors: Guiotto Martino , Sciboz Oana Cristina , Arquero Carmen , Schiraldi Luigi , Di Summa Pietro , Bauquis Olivier , Durand Sébastien
Published: August 2024

Background: Ultrasound shear wave elastography (SWE) noninvasively measures the stiffness of tissue by producing and measuring tissue deformation. Scar formation, a crucial aspect of wound healing, can lead to functional and aesthetic complications when pathological. While SWE has shown promise in dermatological evaluations, its role in surgical scar assessment remains underestimated. Our study aims to investigate SWE in evaluating surgical scars at the donor site after forearm free flap surgery in transgender patients. Methods: After radial forearm free flap harvesting, the donor site was grafted with a split-thickness skin graft with or without interposition of Matriderm. Eleven patients were evaluated more than one year after surgery, using SWE alongside scar characteristics, sensory outcomes, and patient satisfaction surveys. Results: Our study revealed no significant difference in stiffness (p > 0.15), pigmentation (p = 0.32), or erythema (p = 0.06) between operated and non-operated sides. The interposition of Matriderm did not influence the stiffness. Patients significantly (p < 0.0001) reported a loss of discrimination. Patients’ subjective scar evaluation appeared in line with our quantitative and objective results. Conclusions: This study contributes to the evolving understanding of SWE’s role in scar assessment, highlighting its feasibility in evaluating surgical scars. However, continued research efforts are necessary to establish SWE as a reliable and objective method for surgical scar evaluation and management.
Exploring the Complexities of Non-Bacterial Thrombotic Endocarditis: Highlights from Literature and Case Studies
Authors: Santarpino Giuseppe , Lofrumento Francesca , Zito Concetta , Trio Olimpia , Restelli Davide , Cusmà Piccione Maurizio , Manganaro Roberta , Carerj Scipione , Cardetta Francesco , Fiore Corrado , de Gregorio Cesare
Published: August 2024

Non-bacterial thrombotic endocarditis (NBTE) is a form of non-infective endocarditis characterized by the deposition of sterile fibrin and platelets on cardiac valves. Even though some studies have identified important pathophysiological features, many aspects remain poorly understood. Given its wide availability, transthoracic echocardiography is typically the initial diagnostic approach to the patient. Additionally, recent technological advancements in transesophageal echocardiography, such as three-dimensional and multiplanar reconstruction analysis, have significantly improved diagnostic accuracy over time. By presenting our case series and performing a literature review, we focused on the main pathophysiologic, diagnostic, and therapeutic aspects of this rare but potentially life-threatening disease.
Sure Steps: Key Strategies for Protecting Basketball Players from Injuries—A Systematic Review
Authors: Antoranz Yoel , Sáez de Villarreal Eduardo , del Campo Vecino Juan , Jiménez-Saiz Sergio L.
Published: August 2024

Background: Basketball is a high-intensity sport, which includes actions such as jumping, changes of direction, accelerations, and decelerations, which generates fatigue situations that may increase the risk of injury. Specifically, the joints at greatest risk are the ankle and knee, with ankle sprains and anterior cruciate ligament (ACL) tears being the most prevalent injuries. There are several strategies aimed at reducing the incidence, based on training methods or other prophylactic measures. Therefore, the purpose of the study is to perform a systematic review of the different injury prevention strategies in competitive-level basketball players with respect to general injuries, ankle sprains, and ACL injuries. Methods: For this purpose, the PRISMA methodology was applied, performing a search in three databases (PubMed, SPORTDiscus, and Cochrane) between 25 September 2023 and 8 October 2023. Results: A total of 964 articles were identified, out of which 283 were duplicates and 644 were discarded. Out of the remaining 37, 23 were excluded because they did not meet the inclusion criteria; therefore, 14 articles were finally included. With respect to general injuries, 8 out of 14 studies reviewed them. Concerning ankle sprains, 7 studies specifically analyzed them. Finally, 3 studies focused on ACL injuries. Conclusions: Training programs that combine different contents, known as neuromuscular training, including strength work, stabilization or core, mobility, and agility are the most effective for both general injuries and ACL injuries. For ankle sprains, the most effective measures are training programs based on analytical ankle stability exercises and the use of ankle braces. Adherence to prevention programs is essential, so they can be included as part of the warm-up. Other strategies such as training load control, functional assessment, or rule modification are not used in the included articles, so their effectiveness as prophylactic methods could not be justified.
Novel and Promising Therapies for Diabetic Dyslipidemia to Mitigate Residual Cardiovascular Risk
Authors: Jialal Ishwarlal , Gounden Verena
Published: August 2024

Diabetes is a major risk factor for atherosclerotic cardiovascular disease (ASCVD), and the dyslipidemia of diabetes is pivotal in the genesis of this leading cause of increased morbidity and mortality that burdens diabetic patients [...]
Effect of Bismuth Ferrite Nanoparticles on Physicochemical Properties of Polyvinylidene Fluoride-Based Nanocomposites
Authors: Petrukhin Denis , Salnikov Vitalii , Nikitin Aleksey , Sidane Ibtissame , Slimani Sawssen , Alberti Stefano , Peddis Davide , Omelyanchik Alexander , Rodionova Valeria
Published: August 2024

Bismuth ferrite (BiFeO3, BFO) is one of the few single-phase crystalline compounds exhibiting strong multiferroic properties at room temperature, which makes it promising for use in various fields of science and technology. The remarkable characteristics of BFO at the nanoscale position it as a compelling candidate for enhancing the functionalities of polymeric nanocomposite materials. In this study, we explore the fabrication of polyvinylidene fluoride (PVDF) nanocomposites with a variable content of BFO nanopowders (0, 5, 10, 15, 20, and 25 wt%) by solution casting in the form of thin films with the thickness of ~60 µm. Our findings reveal that the presence of BFO nanoparticles slightly facilitates the formation of β- and γ-phases of PVDF, known for their enhanced piezoelectric properties, thereby potentially expanding the utility of PVDF-based materials in sensors, actuators, and energy harvesting devices. On the other hand, the increase in filler concentration leads to enlarged spherulite diameter and porosity of PVDF, as well as an increase in filler content above 20 wt% resulting in a decrease in the degree of crystallinity. The structural changes in the surface were found to increase the hydrophobicity of the nanocomposite surface. Magnetometry indicates that the magnetic properties of nanocomposite are influenced by the BFO nanoparticle content with the saturation magnetization at ~295 K ranging from ~0.08 emu/g to ~0.8 emu/g for samples with the lowest and higher BFO content, respectively.
Experimental Characterization of Stiffness of a Polyester Mooring Rope for a CFPSO
Authors: Feng Limei , Wang Qian , Wang Shan , Xu Sheng
Published: August 2024

Synthetic ropes are increasingly favored for use in offshore systems. Accurate predictions of the coupled hydrodynamic performance and structural response of offshore structures depends on a thorough understanding of the nonlinear characteristics of fiber materials. The objective of this study is to experimentally characterize the stiffness of a polyester mooring rope for a cylindrical floating production storage and offloading system. The quasi-static stiffness of the ropes and aged ropes after installation and the dynamic stiffness in various loading conditions were computed based on sub-rope tests following the guidelines from the American Bureau of Shipping. The quasi-static stiffness curves exhibited a linear decrease in values as the logarithm of the loading period (in minutes) increased. The dynamic stiffness was, in general, much higher than the quasi-static stiffness. The dynamic stiffness under various loading conditions revealed the complexities of the mechanical properties of polyester rope. Parameters such as the mean load, load amplitude, loading period, and loading cycles all had a notable impact. More tests are required to have a better understanding of their effects.
A Review of Stage 0 Biomarkers in Type 1 Diabetes: The Holy Grail of Early Detection and Prevention?
Authors: Mănescu Măriuca , Mănescu Ion , Grama Alina
Published: August 2024

Type 1 diabetes mellitus (T1D) is an incurable autoimmune disease characterized by the destruction of pancreatic islet cells, resulting in lifelong dependency on insulin treatment. There is an abundance of review articles addressing the prediction of T1D; however, most focus on the presymptomatic phases, specifically stages 1 and 2. These stages occur after seroconversion, where therapeutic interventions primarily aim to delay the onset of T1D rather than prevent it. This raises a critical question: what happens before stage 1 in individuals who will eventually develop T1D? Is there a “stage 0” of the disease, and if so, how can we detect it to increase our chances of truly preventing T1D? In pursuit of answers to these questions, this narrative review aimed to highlight recent research in the field of early detection and prediction of T1D, specifically focusing on biomarkers that can predict T1D before the onset of islet autoimmunity. Here, we have compiled influential research from the fields of epigenetics, omics, and microbiota. These studies have identified candidate biomarkers capable of predicting seroconversion from very early stages to several months prior, suggesting that the prophylactic window begins at birth. As the therapeutic landscape evolves from treatment to delay, and ideally from delay to prevention, it is crucial to both identify and validate such “stage 0” biomarkers predictive of islet autoimmunity. In the era of precision medicine, this knowledge will enable early intervention with the potential for delaying, modifying, or completely preventing autoimmunity and T1D in at-risk children.
First-Year Experience or One-Year Experience? The Future of Civic Engagement in Higher Education
Authors: Moots Glenn , Patterson James M.
Published: August 2024

Building on recent civic engagement conversations, this article considers several legal proposals and existing frameworks that are meant to expand opportunities for civic growth and interaction in higher education. Though well intentioned, these proposed and existing guidelines, as we demonstrate, in many cases, restrict the ability of students to learn in traditional ways that facilitate their civic interactions on campus. The suggested and recently implemented reforms include expanded Advanced Placement and Dual Credit opportunities, reduced support for general education classes, and 90 h degrees intended to replace 120 credit hour degrees. The issue with all of these ideas (implemented or not), as we show, is that they amputate what is critical to a genuine undergraduate civic engagement experience: time physically spent on campus, building bonds of trust within a cohort in a way that makes possible the tough conversations, without which true civic connection never becomes a reality. The recommendation of our article as a whole, then—at the local, state, and federal levels—is to use all available legal tools, including ones connected to financial aid and accreditation, to not further reduce time that students are required to spend on campus as a prerequisite of graduation. Maintaining residential requirements, as we further show, will also advance goals of equity and equal access.
Risk Prediction Score for Thermal Mapping of Pharmaceutical Transport Routes in Brazil
Authors: Mangini Clayton Gerber , Lima Nilsa Duarte da Silva , Nääs Irenilza de Alencar
Published: August 2024

Background: The global pharmaceutical industry is crucial for providing medications but faces challenges in distributing products safely, especially in tropical and remote areas. Pharmaceuticals require careful transport control to maintain quality; therefore, manufacturers must adopt optimal distribution strategies to ensure product quality throughout the supply chain. The current research focused on creating a model to assess risk levels and predict risk categorization (low, moderate, and high) associated with thermal mapping across pharmaceutical transportation pathways. Methods: Data from a company for pharmaceutical logistics in Brazil were used. The data had 85,261 instances and six attributes (season, origin, destination, route, temperature, and temperature excursion). The dataset consisted of critical destinations, including the shipment time, cargo temperature, and route information. The classification algorithms (CART-Decision Tree, NB-Naive Bayes, and MP-Multilayer Perceptron) were used to build up a model of rules for predicting risk levels in thermal mapping routes; Results: The MP model presented the best performance, indicating a better application probability. The machine learning model is the basis for an automated risk prediction for routes of pharmaceutical transportation; Conclusions: the developed MP model might automatically predict risk during the distribution of pharmaceutical products, which might lead to optimizing time and costs.
Novel Directions for Neuromorphic Machine Intelligence Guided by Functional Connectivity: A Review
Authors: Illeperuma Mindula , Pina Rafael , De Silva Varuna , Liu Xiaolan
Published: August 2024

As we move into the next stages of the technological revolution, artificial intelligence (AI) that is explainable and sustainable is becoming a key goal for researchers across multiple domains. Leveraging the concept of functional connectivity (FC) in the human brain, this paper provides novel research directions for neuromorphic machine intelligence (NMI) systems that are energy-efficient and human-compatible. This review serves as an accessible review for multidisciplinary researchers introducing a range of concepts inspired by neuroscience and analogous machine learning research. These include possibilities to facilitate network integration and segregation in artificial architectures, a novel learning representation framework inspired by two FC networks utilised in human learning, and we explore the functional connectivity underlying task prioritisation in humans and propose a framework for neuromorphic machines to improve their task-prioritisation and decision-making capabilities. Finally, we provide directions for key application domains such as autonomous driverless vehicles, swarm intelligence, and human augmentation, to name a few. Guided by how regional brain networks interact to facilitate cognition and behaviour such as the ones discussed in this review, we move toward a blueprint for creating NMI that mirrors these processes.
Fibonacci Wavelet Collocation Method for Solving Dengue Fever SIR Model
Authors: Kumar Amit , Khan Ayub , Abdullah Abdullah
Published: August 2024

The main focus in this manuscript is to find a numerical solution of a dengue fever disease model by using the Fibonacci wavelet method. The operational matrix of integration has been obtained using Fibonacci wavelets. The proposed method is called Fibonacci wavelet collocation method (FWCM). This biological model has been transformed into a system of nonlinear algebraic equations by using the Fibonacci wavelet collocation scheme. Afterward, this system has been solved by using the Newton–Raphson method. Finally, we provide evidence that our results are better than those obtained by various current approaches, both numerically and graphically, demonstrating the method’s accuracy and efficiency.
Cognitive Outcomes in Young Adults with Primary Arterial Hypertension: The Role of Cardiovascular Risk Factors and Hypertension-Mediated Organ Damage
Authors: Puteikis Kristijonas , Ažukaitis Karolis , Dadurkevičienė Danguolė , Mikučionytė Dovilė , Simanauskas Kazys , Šileikienė Vaida , Masiliūnas Rytis , Jankauskienė Augustina , Mameniškienė Rūta
Published: August 2024

Background and Objectives: We aimed to explore the association between cognitive performance and markers of hypertension-mediated organ damage (HMOD) in young adults with hypertension. Materials and Methods: A group of adults aged 16 to 45 years with primary arterial hypertension completed a battery of paper-pencil as well as computer-based neuropsychological tests across all major cognitive domains. They also underwent office and ambulatory 24 h blood pressure, intima-media thickness measurements, heart ultrasound, and laboratory analysis of their lipid profile, blood uric acid concentration, and urine albumin-creatinine ratio. Associations between cognitive test results and markers of HMOD were explored through correlation analysis and age-, sex-, and body mass index-adjusted linear regression modeling. Results: Seventy-six individuals (62, 81.6% male) aged 36.5 years (interquartile range 18.4 to 42.0 years) were enrolled. After adjusting for age, sex, and body mass index in linear regression models, worse categorical fluency was associated with higher left ventricular mass (βst = −0.264, p = 0.043) and worse performance in a task of sustained attention—with higher left ventricular mass index (βst = −0. 304, p = 0.016). Worse phonemic fluency was related to higher pulse pressure (βst = −0.241, p = 0.049) in the respective model. Better strategy use in the task of spatial working memory was linked to higher daytime mean diastolic blood pressure (βst = −0.343 p = 0.017). Conclusions: Performance among young adults with hypertension across selected cognitive domains was inversely associated with pulse pressure, markers of left ventricular damage, and directly associated with daytime diastolic blood pressure. Our study suggests that the previously reported relationship between cognitive and cardiovascular markers in hypertension exists earlier than in middle or late adulthood.
Material Properties and Friction and Wear Behavior of Ti–18 mass% Nb Alloy after Gas Nitriding and Quenching Process
Authors: Mantani Yoshikazu , Tsuji Miku , Akada Eri , Homma Tomoyuki
Published: August 2024

We performed a gas nitriding and quenching process (GNQP) on Ti–18 mass% Nb alloy to obtain a high damping capacity and wear resistance. GNQP was performed at temperatures of 1023, 1123, and 1223 K. The outermost surface of the GNQP specimen obtained at 1023 K mainly comprised TiO2, whereas that at 1223 K mainly comprised TiN. The surface and interior of the specimens exhibited higher hardness at 1223 K than that at 1023 K. Compared to the specimen obtained by solution–quenching (AQ), the unit volume of the α” martensite phase at a depth of 320 μm of the GNQP specimen obtained at 1023 K was similar, and that at 1223 K was higher. Such a difference can be related to the difference in the core hardness of the specimens. The wear amounts of all GNQP specimens were lower than those of the AQ specimen. The coefficient of friction of the GNQP specimen obtained at 1023 K was lower than that obtained at 1223 K. The surface constituent phase and surface roughness exhibited a strong influence on the wear at a load of 500 g. Meanwhile, the nitride layer and damping capacity were considered to be related to the wear at a load of 3000 g.