bluuebunny/crossref_metadata_2025 huggingface dataset:
Serum Adiponectin Is Elevated in Critically Ill Patients with Liver Disease and Associated with Decreased Overall Survival
Authors: Pollmanns Maike R. , Pajaziti Qendrim , Hohlstein Philipp , Adams Jule K. , Abu Jhaisha Samira , Kabak Elena , Hamesch Karim , Nusser Sophie H. A. , Weiskirchen Ralf , Wirtz Theresa H. , Koch Alexander
Published: September 2024

Background: Adiponectin, an adipokine with anti-inflammatory properties, has been implicated in various liver diseases. This study aimed to elucidate the prognostic value of serum adiponectin levels in critically ill patients with liver disease. Methods: This observational study included 161 critically ill patients admitted to the medical ICU of RWTH Aachen University Hospital due to acute liver failure or decompensated advanced chronic liver disease. Serum adiponectin levels were measured at ICU admission and after 48 h. Clinical parameters and outcomes, including transplant-free survival, were analyzed. Results: Serum adiponectin concentrations were significantly elevated compared to healthy controls (p < 0.001). Levels were particularly high in patients with sepsis compared to those with gastrointestinal bleeding as the precipitating factor of acute decompensation (p = 0.045) and were higher in female patients (p = 0.023). Adiponectin concentrations correlated with the Model of End-Stage Liver Disease (MELD) score and Child–Pugh score. Multivariate analysis confirmed a significant correlation with total bilirubin (r = 0.292, p < 0.001) and serum sodium (r = −0.265, p = 0.028). Higher adiponectin concentrations were associated with a trend towards poorer 30- and 180-day survival. Cox regression analysis identified a significant association between increased adiponectin concentration and reduced transplant-free survival (p = 0.037), supported by a Kaplan–Meier analysis using a cutoff of 119 ng/mL (log-rank 5.145, p = 0.023). Conclusions: Elevated serum adiponectin concentrations are associated with liver dysfunction and poor outcomes in critically ill patients. Higher adiponectin levels at ICU admission may predict poorer transplant-free survival. Further research in larger, multicenter cohorts is warranted to validate these findings and explore the underlying mechanisms.
Idiosyncratic Hepatocellular Drug-Induced Liver Injury by Flucloxacillin with Evidence Based on Roussel Uclaf Causality Assessment Method and HLA B*57:01 Genotype: From Metabolic CYP 3A4/3A7 to Immune Mechanisms
Authors: Teschke Rolf
Published: September 2024

Idiosyncratic drug-induced liver injury (iDILI) by flucloxacillin presents as both cholestatic and hepatocellular injury. Its mechanistic steps are explored in the present analysis as limited data exist on the cascade of events leading to iDILI in patients with an established diagnosis assessed for causality by the Roussel Uclaf Causality Assessment Method (RUCAM). Studies with human liver microsomes showed that flucloxacillin is a substrate of cytochrome P450 (CYP) with ist preferred isoforms CYP 3A4/3A7 that toxified flucloxacillin toward 5′-hydroxymethylflucloxacillin, which was cytotoxic to human biliary epithelial cell cultures, simulating human cholestatic injury. This provided evidence for a restricted role of the metabolic CYP-dependent hypothesis. In contrast, 5′-hydroxymethylflucloxacillin generated metabolically via CYP 3A4/3A7 was not cytotoxic to human hepatocytes due to missing genetic host features and a lack of non-parenchymal cells, including immune cells, which commonly surround the hepatocytes in the intact liver in abundance. This indicated a mechanistic gap regarding the clinical hepatocellular iDILI, now closed by additional studies and clinical evidence based on HLA B*57:01-positive patients with iDILI by flucloxacillin and a verified diagnosis by the RUCAM. Naïve T-cells from volunteers expressing HLA B*57:01 activated by flucloxacillin when the drug antigen was presented by dendritic cells provided the immunological basis for hepatocellular iDILI caused by flucloxacillin. HLA B*57:01-restricted activation of drug-specific T-cells caused covalent binding of flucloxacillin to albumin acting as a hapten. Following drug stimulation, T-cell clones expressing CCR4 and CCR9 migrated toward CCL17 and CCL25 and secreted interferon-γ and cytokines. In conclusion, cholestatic injury can be explained metabolically, while hepatocellular injury requires both metabolic and immune activation.
A Novel Aerial-Aquatic Unmanned Vehicle Using Flapping Wings for Underwater Propulsion
Authors: He Jiacheng , Zhang Yingjie , Feng Junjun , Li Shisheng , Yuan Yiheng , Wang Pinghui , Han Song
Published: September 2024

Aerial-aquatic unmanned vehicles are a combination of unmanned aerial vehicles and unmanned submersibles, capable of conducting patrols in both the air and underwater domains. This article introduces a novel aerial-aquatic unmanned vehicle that integrates fixed-wing configuration and flapping-wing configuration. In order to improve the low efficiency of the classic diagonal motion trajectory, this paper proposed an improved diagonal motion trajectory based on joint optimization of the stroke angle and angle of attack curve. The proposed method has been verified through simulations and experiments. A prototype was developed and experiments were completed, both indoors and outdoors, wherein the system’s transmedium transition capability and flapping propulsion performance were comprehensively validated. Additionally, utilizing flapping propulsion, an average underwater propulsion speed of 0.92 m/s was achieved.
Exploring Burnout, Work Addiction, and Stress-Related Growth among Prehospital Emergency Personnel
Authors: Puticiu Monica , Grecu Mihai-Bujor , Rotaru Luciana Teodora , Butoi Mihai Alexandru , Vancu Gabriela , Corlade-Andrei Mihaela , Cimpoesu Diana , Tat Raluca Mihaela , Golea Adela
Published: September 2024

Burnout and stress-related issues are significant concerns among medical personnel involved in emergency situations due to the high demands of their work. A cross-sectional descriptive and comparative study was conducted on 266 prehospital emergency personnel across five Romanian counties, comprising 41 physicians, 74 nurses, and 151 paramedics. Data were collected through an online form, including demographic and professional characteristics, and five validated scales. This study revealed moderate (49.3%) to high (25.9%) burnout rates, with 35% showing signs of work addiction. Despite these challenges, the personnel demonstrated high levels of stress-related growth (61.2%), strong self-discipline (74.1%), and low to moderate responsive distress (100%). Physicians exhibited higher work addiction and job satisfaction, whereas paramedics faced higher burnout, self-discipline, and distress levels. Nurses showed lower burnout and self-discipline levels. These findings highlight the prevalence of burnout and work addiction among emergency medical personnel, while also underscoring the presence of protective factors like higher self-discipline, good level of stress-related growth, and low to moderate responsive distress. The distinct differences in experiences among physicians, nurses, and paramedics emphasize the need for tailored strategies to address these issues within each group.
Considering the Role of Behavioural Fatigue in the COVID-19 Lockdown Debates in Great Britain: A Retrospective Analysis of a National Survey Assessing the Relationships between Capability, Opportunity, Motivation, and Behaviour
Authors: Khanal Saval , Schmidtke Kelly Ann , Haralampiev Kaloyan , Vlaev Ivo
Published: September 2024

During the COVID-19 pandemic, the term “behavioural fatigue” became the centre of policy debates in Great Britain. These debates involved deciding when to go into lockdown and whether behavioural interventions could be effective. Behavioural interventions can only succeed where people’s Capabilities, Opportunities, and Motivations to perform target behaviours are supported. Our retrospective data analyses examine the relationships between people’s Capabilities, Opportunities, Motivations, and Behaviours, i.e., adherence to lockdown guidelines. Our cross-sectional analyses include 17,962 unique participants in Great Britain who completed a survey over the initial 30 days of the first lockdown (April 2020). We examine trends in responses to each scale and then the relationships between the scales using Granger’s causality test with tests for stationarity and cointegration. A mixture of increasing and decreasing trends was identified for Capabilities and Opportunities. Decreasing trends were identified for Motivation and Behaviour. Granger’s causality tests found that Capability forecasts Opportunity and Behaviour and that Motivation forecasts Opportunity. The discussion reiterates that to realise and maintain Behaviour changes, policies surrounding people’s Capabilities, Opportunities, and Motivations must continue to support target behaviours.
Examining the Effect of Knowledge Seeking on Knowledge Contribution in Q&A Communities
Authors: Qiu Junping , Mi Qinze , Xu Zhongyang , Ma Shihao , Fu Yutian , Zhang Tingyong
Published: September 2024

Based on motivational theory, this study investigated the effect of users’ knowledge seeking on users’ knowledge contribution in question-and-answer (Q&A) communities. We collected 4643 samples from the largest social Q&A platform in China (Zhihu) and applied a mediation effect test to the data. The results showed that knowledge seeking affects intrinsic motivations (altruism and self-efficacy) and extrinsic motivations (social support, group identity, and reputation), further affecting knowledge contribution. Our findings indicated that Q&A communities should be concerned with users’ intrinsic and extrinsic motivations to ensure balanced knowledge exchange on social Q&A platforms, ultimately fostering long-term stability and growth. Existing research has mainly focused on a single behavioral state, such as knowledge seeking or knowledge contribution, and has paid little attention to the connection between these two types of user information behaviors. This study aimed to fill this gap by revealing the mechanisms through which users’ knowledge seeking affects their knowledge contribution.
Telerobotic Intergroup Contact: Acceptance and Preferences in Israel and Palestine
Authors: Peled Avner , Leinonen Teemu , Hasler Béatrice S.
Published: September 2024

We explore telerobotics as a novel form of intergroup communication. In this form, remotely operated robots facilitate embodied and situated intergroup contact between groups in conflict over long distances, potentially reducing prejudice and promoting positive social change. Based on previous conceptual frameworks and design hypotheses, we conducted a survey on the acceptance and preferences of the telerobotic medium in Israel and Palestine. We analyzed the responses using a mixed-method approach. The results shed light on differences in attitudes between the groups and design considerations for telerobots when used for intergroup contact. This study serves as a foundation for the implementation of a novel method of technology-enhanced conflict resolution in the field.
The Impact of Pressure Training on the Performance of Semi-Professional Female Rugby League Players
Authors: Lastella Michele , Upton Sharni , Miller Dean J.
Published: September 2024

Background: The aim of this study was to examine the effect of pressure training on the performance of semi-professional female rugby league athletes. Methods: Using a within-subjects design, 16 female athletes (19.9 ± 3.4 years) performed a passing accuracy task under three conditions; (1) a control condition; (2) a physiological fatigue condition; and (3) a threat of consequence condition. Passing performance, perceived pressure, rate of perceived exertion (RPE), and self-confidence were assessed. Results: A significant main effect of conditions was found for rate of perceived exertion (p < 0.001), self-confidence (p < 0.028), and perceived pressure (p = 0.011). There was no main effect of condition on passing performance. Post hoc comparisons revealed that RPE was significantly higher in the physiological fatigue condition when compared to the control (p = 0.009) and threat of consequence conditions (p < 0.001). Perceived pressure was significantly higher in the threat of consequence condition compared to the control condition (p = 0.037). Conclusions: The main findings of this study are that (1) passing performance was not impacted by pressure training conditions, and (2) threats of consequences are an effective manipulation to generate pressure in female semi-professional rugby league players. These results offer nuanced insights into the impact of pressure generation in training environments for female semi-professional rugby league athletes.
From Tradition to Innovation: Analyzing Strategies and Support for Enhancing Badminton Course Teaching Quality through Educational Technology
Authors: Lin Mei-Ling , Chen Nan-Chi , Luo Yu-Jy , Liao Chun-Chin , Kao Chun-Chieh
Published: September 2024

This study aims to explore the impact of Multimedia-Assisted Teaching (MAT) on the quality of physical education (PE) instruction in universities, with a particular focus on badminton courses. A quasi-experimental design was employed, including pre-tests and post-tests, involving two badminton classes at Ming Chuan University, with a total of 101 students. These two classes were assigned to an experimental group (using MAT) and a control group (traditional teaching methods). The research instrument used was the Physical Education Teaching Quality Scale (PETQ), which includes four factors: course content, teaching strategies, classroom management, and learning assessment. The results indicated that, compared to traditional teaching methods, the use of MAT significantly enhanced students’ perception of the quality of PE instruction. The experimental group scored significantly higher than the control group across all scale factors, suggesting that MAT is more effective in capturing students’ attention and improving learning outcomes. The conclusion suggests that MAT has significant advantages in improving the quality of physical education instruction. The integration of MAT enables more flexible lesson planning and enhances the learning process through the features of multimedia-assisted teaching. It is recommended that physical education teachers consider applying multimedia technologies to aid teaching, in order to increase student engagement and effectiveness.
It Is Leadership, but (Maybe) Not as You Know It: Advocating for a Diversity Paradigm in Sports Leadership and Beyond
Authors: Cassidy Tania , Byrne Gary
Published: September 2024

The need to ‘rethink leadership’ is on the radar of many, from global finance and auditing organisations (e.g., Deloitte) and global sports organisations (e.g., the International Olympic Committee) to national and local sports organisations concerned about the decreasing numbers of participants or the lack of women coaches. Yet, is the dominant Western leadership orthodoxy fit for purpose in the 21st century? The purpose of this article is two-fold. First, to advocate for ways of ‘rethinking leadership’ that challenge the current dominant ethnocentric, gender-biased, leader-centric orthodoxy. Second, to introduce an expanded global and diverse leadership paradigm that is underpinned by clearly delineated dimensions of diversity and cultural competence, which recognises the importance of the organisational and cultural contexts. The literature discussed in this article draws from leadership studies generally and sports leadership and sports coaching more specifically. Key to this article is the discussion of the implications of adopting a diverse leadership paradigm for policy, practice, development, and research of leadership. This advocacy article does not end with a definitive conclusion but rather with an invitation to participate in a journey to realise the potential of diverse leadership.
Navigating and Resisting Educational Systems: The Experiences of Latinx Families in Rural Oregon
Authors: Díaz Lara Guadalupe , Dodge Tina , Colomer Soria E. , López-Cevallos Daniel F.
Published: September 2024

This study explores the experiences of Latinx parents in rural Oregon from the perspectives of Latinx parents, Latinx students, and community practitioners to understand the barriers Latinx families encounter and how they leverage their community cultural wealth to address these barriers within the context of initiatives implemented by the district. This qualitative study is guided by the following questions: What barriers do Latinx families encounter in rural schools, and how do parents leverage their community cultural wealth to address these barriers? Findings indicate that even when families were engaged in initiatives (e.g., dual language immersion programs) implemented by the district to create a welcoming environment, Latinx parents continued to encounter multiple systemic barriers (e.g., immigration laws) and leveraged multiple forms of community cultural wealth (e.g., linguistic capital) to navigate these barriers. Our findings reveal the complex dynamics at play in rural school communities serving Latinx families.
Walking Environment Satisfaction in an Historic Block Based on POE and Machine Learning: A Case Study of Tianjin Five Avenues
Authors: Yu Ziyao , Zhou Yanwei , Wang Heng
Published: September 2024

The increasing volume of motorized traffic not only negatively impacts the structural preservation and overall planning of individual buildings within the block but also disrupts the originally harmonious and pleasant spatial environment of the area. Walking, as a primary mode of urban transportation, plays a crucial role in preserving the unique characteristics of historical blocks, enhancing the quality of the urban environment, and achieving long-term sustainable urban development. This study takes the Five Avenues historical block as a case, assessing the current walking environment from the perspective of Post-Occupancy Evaluation (POE). Machine learning techniques (including web scraping, the TF-IDF algorithm, and the LDA model) were employed to collect and analyze user feedback data, assisting in constructing walking environment satisfaction indicators. A total of 19 key factors affecting walking satisfaction were identified. Paired sample t-tests, ANOVA, and reliability and validity analyses were applied to examine the feasibility and practicality of the questionnaire content. Finally, using Importance–Performance Analysis (IPA), the improvement priorities for walking environment indicators were clearly defined. Although the overall satisfaction index of the Five Avenues is comparatively high, unobstructed pathways have the greatest impact on walking environment satisfaction, followed by the rationality of guiding signage facilities, and then by public security management and facility maintenance. Furthermore, visitors prioritize factors such as the cultural recognizability of the area, travel convenience, green space accessibility, and the sidewalk width proportion; they are less focused on the functional aspects of the walkways. Based on the analysis results from POE and machine learning, targeted strategies for improving the walking environment in historical blocks were proposed, aiming to provide a more comprehensive basis for improving the walking environments of similar blocks.
An Investigation of Globe Temperature in Street Canyons: A Scaled Model Study Implementing Cool Materials
Authors: Kumar Donthu E. V. S. Kiran , Shashwat Shashwat , Zingre Kishor T. , Srinivasan Seshadhri , Wan Man Pun
Published: September 2024

The measurement of globe temperature (GT) is essential for investigating pedestrian thermal comfort in street canyons. The globe thermometer is the most common instrument used to measure GT; however, its application in scale models has not been thoroughly investigated to date. Therefore, this study explicitly investigates globe thermometer measurements in scale models and analyzes the need for customization of the globe thermometer for more reliable measurements. Scaling down with respect to the size of the globe thermometer and the effect of solar orientation/envelope materials are investigated in this study. The initial experiments were carried out in an outdoor setting using a typical street canyon model (scale 1:100) with an east-west street orientation. The results of the experiment are presented to compare a low solar reflectance street canyon (albedo of 0.4) and a high solar reflectance canyon (albedo of 0.6) in terms of surface temperatures, heat flux, and globe temperature. It is observed that although the wall and road surface temperatures are lower for the high solar reflectance canyon compared to those for the low solar reflectance canyon, the GT (measured at pedestrian height) is higher in a high reflectance canyon during the daytime, which could be due to the combined effect of direct radiation and short-wave reflection. However, for the hours after sunset, a reverse effect is observed, i.e., the GT becomes lower (up to 0.8 °C) in the case of a high reflectance canyon compared to that for the low reflectance canyon. Furthermore, the study emphasizes the impact of solar reflectance of canyon surfaces on GT values, due to the view factors that the globe thermometer on those surfaces.
A New Continuous Strength Method for Prediction of Strain-Hardening Performance of High-Strength Aluminum Alloy Cylindrical Columns
Authors: Chen Lihui , Xu Weikai , Chen Yusong , Sun Weipeng
Published: September 2024

This paper aims to develop a new continuous strength method (CSM) to more accurately predict the strain-hardening characteristics of high-strength aluminum alloy circular hollow sections (CHSs) under axial compression. A total of 11 stub column specimens made of 7A04-T6 and 6061-T6 aluminum alloys underwent testing. Additionally, 16 sets of experiment data were gathered from open sources, encompassing various aluminum alloy types such as 6082-T6, 6061-T6, and 6063-T5. Validated by experimental result, the finite element (FE) model was applied in a series of comprehensive parameter studies, supplementing the limited test result of high-strength aluminum alloy stub columns. Based on the experiment and FE results, this paper proposes a new CSM relation to determine the cross-sectional resistance of high-strength non-slender CHS aluminum alloys under compression. The cross-sectional resistance obtained from tests are compared with predicted strengths determined using the European code, as well as the solution of the CSM proposed in a previous study and in this paper. The comparison illustrates that the strength predictions in the European code and the previous study are conservative. Compared with the European code and the previous study, the strength prediction formula proposed in this paper improves accuracy by 11% and 5%, respectively, while reducing scatter by 8.4% and 2%, respectively.
A Review of the Mechanical Properties of and Long-Term Behavior Research on Box Girder Bridges with Corrugated Steel Webs
Authors: Zheng Yuanxun , Wang Jiahao , Guo Pan , Zhang Yong
Published: September 2024

Based on an analysis of the extant literature, this paper summarizes the research progress on the mechanical properties and long-term behavior of corrugated steel web (CSW) box girder bridges. First, the research results of CSW box girder bridges in terms of the shear buckling performance (local shear buckling, overall shear buckling, and interaction buckling), bending performance, bending capacity, torsional capacity, and coefficient of internal force increase are summarized, along with the main factors affecting the mechanical performance of CSW box girder bridges. Second, based on research on the self-oscillation characteristics and dynamic response of CSW box girder bridges, the influence of structural parameters on the self-oscillation characteristics is analyzed. Finally, the long-term mechanical behavior of the CSW box girder bridges is analyzed in terms of fatigue, creep, and temperature effects. The existing research results demonstrate that there still exist deficiencies in the mechanical properties and long-term behavior of CSW box girder bridges, and this paper thus suggests a future research focus on CSW box girder bridges to provide a reference for further improving their basic theoretical system.
Deep Learning-Based Intelligent Detection Algorithm for Surface Disease in Concrete Buildings
Authors: Gu Jing , Pan Yijuan , Zhang Jingjing
Published: September 2024

In this study, the extent of concrete building distress is used to determine whether a building needs to be demolished and maintained, and the study focuses on accurately identifying target distress in different complex contexts and accurately distinguishing between their categories. To solve the problem of insufficient feature extraction of small targets in bridge disease images under complex backgrounds and noise, we propose the YOLOv8 Dynamic Plus model. First, we enhanced attention on multi-scale disease features by implementing structural reparameterization with parallel small-kernel expansion convolution. Next, we reconstructed the relationship between localization and classification tasks in the detection head and implemented dynamic selection of interactive features using a feature extractor to improve the accuracy of classification and recognition. Finally, to address problems of missed detection, such as inadequate extraction of small targets, we extended the original YOLOv8 architecture by adding a layer in the feature extraction phase dedicated to small-target detection. This modification integrated the neck part more effectively with the shallow features of the original three-layer YOLOv8 feature extraction stage. The improved YOLOv8 Dynamic Plus model demonstrated a 7.4 percentage-point increase in performance compared to the original model, validating the feasibility of our approach and enhancing its capability for building disease detection. In practice, this improvement has led to more accurate maintenance and safety assessments of concrete buildings and earlier detection of potential structural problems, resulting in lower maintenance costs and longer building life. This not only improves the safety of buildings but also brings significant economic benefits and social value to the industries involved.
Shaking Table Tests and Numerical Study on the Seismic Performance of Arc-Shaped Shear Keys in Highway Continuous-Girder Bridges
Authors: Huang Liang , Wang Wenze , Xu Shizhan , Wang Bo , Li Zisheng
Published: September 2024

Typical forms of seismic damage to laminated-rubber-bearing girder bridges in the transverse direction are falling beams, girder displacement, and bearing damage. However, the damage to piers and foundations is generally lighter. This is mainly due to slippage of the bearings. Therefore, we propose a new type of arc-shaped shear key to improve the lateral seismic performance. A 1/12-scale highway continuous-girder bridge isolated by different shear keys was tested utilizing a 4 m × 4 m shaking table with six DOFs. The seismic responses of the bridge were analyzed in terms of phenomenon, displacement, strain, and acceleration. The main girder and pier exhibited different seismic responses because the bridge had different stops. A numerical simulation based on FEM showed that the established finite element model can well reproduce the displacement time history of the main girder and the cap girder. By analyzing the finite element model, the relative displacement of the bearing under different seismic waves was obtained. A comparison between the measured and FEM responses showed that the arc-shaped shear key can well limit the displacement of the main girder and the bearing. In addition, it does not significantly amplify the seismic response of the substructure. The arc-shaped shear key dissipates more energy while limiting the displacement of the main girder, and the comprehensive seismic performance is better than that of the rubber pad shear key.
Dynamic Viscoelastic Behavior of Epoxy Asphalt Mixture under Four-Point Bending
Authors: He Baiqing , Huang Zhiyong , Chen Jingsong , He Mu , Wang Yan , Li Jian , Wang Shaohuai
Published: September 2024

Given the dominant failure mode of steel bridge deck pavement layers, which is flexural–tensile damage, the dynamic modulus parameters conventionally determined through uniaxial compression testing are found to be inadequate for the design or performance analysis of these layers. In order to simulate the actual stress of a pavement structure under wheel load, the four-point bending fatigue test method and uniaxial compression test method are used to measure the dynamic modulus of an epoxy asphalt mixture, and the differences between the two test methods are analyzed. Furthermore, the four-point bending fatigue test is employed to investigate the dynamic modulus and phase angle properties across varying temperatures and frequencies, facilitating the creation of master curves for these properties and utilizing Sigmoidal models to correlate dynamic modulus data at diverse temperature conditions. This study delves into the influence of epoxy resin content, mixture composition, and aging on the dynamic modulus. The experimental results show that the dynamic modulus measured by uniaxial compression exceeds that obtained from bending fatigue tests, with the difference initially increasing and then decreasing as temperature rises. This discrepancy significantly impacts the mechanical calculations of pavement layers, underscoring the importance of selecting the appropriate testing method. Temperature, frequency, and epoxy resin content have pronounced effects on the viscoelastic properties of the mixtures. Specifically, as temperature increases, the dynamic modulus undergoes a decrease, whereas the phase angle exhibits an increase. Additionally, the dynamic modulus augments with an increase in loading frequency, while the phase angle exhibits varied trends with frequency shifts across different temperatures. Both the WLF and Sigmoidal models are effective in constructing master curve representations for the dynamic flexural modulus and phase angle. The incorporation of epoxy resin transforms asphalt from a primarily viscous to a more elastic material, significantly enhancing the viscoelastic properties of the mixture. Notably, mixtures with 50% and 60% epoxy resin content exhibit comparable dynamic moduli and phase angles, while displaying notably superior performance compared to those with 40% epoxy resin content. For large-scale steel bridge deck pavement, 50% epoxy resin content is recommended. Moreover, epoxy asphalt mixtures demonstrate robust aging resistance, with minimal variations in the dynamic modulus and phase angle before and after aging. The research results can enable the acquisition of dynamic modulus and phase angle data in the whole temperature domain and the whole frequency domain, and provide reliable mixed performance parameters for the study of different application environmental performance of steel bridge deck pavement.
Improved Outcomes in Myelofibrosis after Allogeneic Stem-Cell Transplantation in the Era of Ruxolitinib Pretreatment and Intensified Conditioning Regimen—Single-Center Analysis
Authors: Machherndl-Spandl Sigrid , Hannouf Sarah , Nikoloudis Alexander , Zach Otto , Strassl Irene , Kaynak Emine , Webersinke Gerald , Gruber-Rossipal Christine , Rumpold Holger , Schimetta Wolfgang , Clausen Johannes , Buxhofer-Ausch Veronika
Published: September 2024

(1) Background: Allogeneic hematopoietic stem-cell transplantation (allo-HSCT) is the only treatment with the potential for cure in patients with myelofibrosis (MF). However, the risk of graft rejection, which is particularly high in MF, and the risk of significant non-relapse mortality must be considered. (2) Methods: In this retrospective, single-center study, we compared allo-HSCT outcomes in 36 adult patients with MF transplanted at two-time intervals (2001–2015 versus 2016–2021). (3) Results: The estimated median overall survival was 48.9 months (95%CI 0.00–98.2) in the cohort transplanted before 2016 and not reached in the more recent years (p = 0.04) due to markedly lower non-relapse mortality (p = 0.02). The 3-year relapse incidence was low in both cohorts (11.1% and 12.5%, p > 0.99). When comparing only subgroups within the more recent cohort based on the presence or absence of total body irradiation (TBI) or the use of sequential regimens, OS and PFS were comparable. (4) Conclusion: Pretreatment with ruxolitinib, intensified conditioning, and the preferential use of haploidentical related instead of mismatched unrelated donors for patients lacking an HLA-identical donor are most likely responsible for the improved outcome after allo-HCT in MF in recent years.
PLK1 Inhibitor Onvansertib Enhances the Efficacy of Alpelisib in PIK3CA-Mutated HR-Positive Breast Cancer Resistant to Palbociclib and Endocrine Therapy: Preclinical Insights
Authors: Sreekumar Sreeja , Montaudon Elodie , Klein Davis , Gonzalez Migdalia E. , Painsec Pierre , Derrien Héloise , Sourd Laura , Smeal Tod , Marangoni Elisabetta , Ridinger Maya
Published: September 2024

Background: Endocrine therapy (ET) combined with cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) is the preferred first-line treatment for hormone receptor-positive (HR+)/HER2- metastatic breast cancer. Although this is beneficial, acquired resistance leads to disease progression, and patients harboring PIK3CA mutations are treated with targeted therapies such as the PI3Kα inhibitor, alpelisib, alongside ET. Drug-associated resistance mechanisms limit the efficacy of alpelisib, highlighting the need for better combination therapies. This study aimed to evaluate the efficacy of combining alpelisib with a highly specific PLK1 inhibitor, onvansertib, in PIK3CA-mutant HR+ breast cancer preclinical models. Methods: We assessed the effect of the alpelisib and onvansertib combination on cell viability, PI3K signaling pathway, cell cycle phase distribution and apoptosis in PI3K-activated HR+ breast cancer cell lines. The antitumor activity of the combination was evaluated in three PIK3CA-mutant HR+ breast cancer patient-derived xenograft (PDX) models, resistant to ET and CDK4/6 inhibitor palbociclib. Pharmacodynamics studies were performed using immunohistochemistry and Simple Western analyses in tumor tissues. Results: The combination synergistically inhibited cell viability, suppressed PI3K signaling, induced G2/M arrest and apoptosis in PI3K-activated cell lines. In the three PDX models, the combination demonstrated superior anti-tumor activity compared to the single agents. Pharmacodynamic studies confirmed the inhibition of both PLK1 and PI3K activity and pronounced apoptosis in the combination-treated tumors. Conclusions: Our findings support that targeting PLK1 and PI3Kα with onvansertib and alpelisib, respectively, may be a promising strategy for patients with PIK3CA-mutant HR+ breast cancer failing ET + CDK4/6i therapies and warrant clinical evaluation.
Revisiting HER2 in Prostate Cancer from an Inclusive Perspective: From Biomarkers to Omics
Authors: Mavingire Nicole , Moore Janelle C. , Johnson Jabril R. , Dwead Abdulrahman M. , Cropp Cheryl D. , Mechref Yehia , Kobeissy Firas , Rais-Bahrami Soroush , Woods-Burnham Leanne
Published: September 2024

Human epidermal growth factor receptor 2 (HER2) is a major driver of disease progression, treatment resistance, and worse survival for patients with various types of cancers, including prostate cancer. However, key bench studies and clinical trials have failed to evaluate the role of HER2 in prostate cancer using racially diverse experimental designs and protocols. This lack of diversity represents what has been the status quo of cancer research in the United States for decades. In the case of prostate cancer, homogenic study designs are problematic as Black men are much more likely to be diagnosed and die from aggressive and incurable forms of the disease. Therefore, the strategic inclusion of biospecimens collected from Black patients as well as the recruitment and enrollment of Black men into prostate cancer clinical trials is necessary to comprehensively evaluate genetic and molecular factors that contribute to variable outcomes in this high-risk population. Additionally, a higher prevalence of HER2 expression in Black men was recently reported in a small cohort of prostate cancer patients and may contribute to worsened prognosis. In this review, we carefully consider the role of HER2 in prostate cancer while, for the first time, taking into account the influences of race and genetic ancestry.
Signature Genes Selection and Functional Analysis of Astrocytoma Phenotypes: A Comparative Study
Authors: Drozdz Anna , McInerney Caitriona E. , Prise Kevin M. , Spence Veronica J. , Sousa Jose
Published: September 2024

Novel cancer biomarkers discoveries are driven by the application of omics technologies. The vast quantity of highly dimensional data necessitates the implementation of feature selection. The mathematical basis of different selection methods varies considerably, which may influence subsequent inferences. In the study, feature selection and classification methods were employed to identify six signature gene sets of grade 2 and 3 astrocytoma samples from the Rembrandt repository. Subsequently, the impact of these variables on classification and further discovery of biological patterns was analysed. Principal component analysis (PCA), uniform manifold approximation and projection (UMAP), and hierarchical clustering revealed that the data set (10,096 genes) exhibited a high degree of noise, feature redundancy, and lack of distinct patterns. The application of feature selection methods resulted in a reduction in the number of genes to between 28 and 128. Notably, no single gene was selected by all of the methods tested. Selection led to an increase in classification accuracy and noise reduction. Significant differences in the Gene Ontology terms were discovered, with only 13 terms overlapping. One selection method did not result in any enriched terms. KEGG pathway analysis revealed only one pathway in common (cell cycle), while the two methods did not yield any enriched pathways. The results demonstrated a significant difference in outcomes when classification-type algorithms were utilised in comparison to mixed types (selection and classification). This may result in the inadvertent omission of biological phenomena, while simultaneously achieving enhanced classification outcomes.
Epithelial–Mesenchymal Plasticity and Epigenetic Heterogeneity in Cancer
Authors: Sacco Jessica L. , Gomez Esther W.
Published: September 2024

The tumor microenvironment comprises various cell types and experiences dynamic alterations in physical and mechanical properties as cancer progresses. Intratumoral heterogeneity is associated with poor prognosis and poses therapeutic challenges, and recent studies have begun to identify the cellular mechanisms that contribute to phenotypic diversity within tumors. This review will describe epithelial–mesenchymal (E/M) plasticity and its contribution to phenotypic heterogeneity in tumors as well as how epigenetic factors, such as histone modifications, histone modifying enzymes, DNA methylation, and chromatin remodeling, regulate and maintain E/M phenotypes. This review will also report how mechanical properties vary across tumors and regulate epigenetic modifications and E/M plasticity. Finally, it highlights how intratumoral heterogeneity impacts therapeutic efficacy and provides potential therapeutic targets to improve cancer treatments.
Adverse Childhood Events Significantly Impact Depression and Mental Distress in Adults with a History of Cancer
Authors: Babatunde Oluwole A. , Gonzalez Katherine , Osazuwa-Peters Nosayaba , Adams Swann Arp , Hughes Halbert Chanita , Clark Frank , Nagar Anusuiya , Obeysekare Jessica , Adjei Boakye Eric
Published: September 2024

Objectives: Adverse childhood experiences (ACEs) are linked to a heightened risk of depression. We explored the relationship between ACEs and both depression and mental distress among cancer survivors. Methods: This was a cross-sectional analysis using the 2022 Behavioral Risk Factor Surveillance System database of cancer survivors aged ≥18 (n = 14,132). The primary outcome was self-reported history of depression, and the secondary outcome was mental distress. The exposure variable was the number of ACEs, classified as 0, 1–2, and ≥3. Weighted multivariable logistic regression models assessed the association between the number of ACEs and depression and mental distress while adjusting for covariates. Results: Approximately 22% of respondents reported experiencing ≥3 ACEs. The prevalence of depression was 21.8%, and mental distress was 15.4%. Compared with cancer survivors who had experienced 0 ACEs, those who had experienced ≥3 (aOR = 3.94; 95% CI, 3.04–5.10) or 1–2 (aOR = 1.85; 95% CI, 1.47–2.32) ACEs had a higher likelihood of reporting depression. Compared with cancer survivors who had experienced 0 ACEs, those who had experienced ≥3 (aOR = 0.67; 95% CI, 0.48–0.93) had a lower likelihood of reporting mental distress. Conclusions: This study highlights the impact of ACEs on depression in adulthood among cancer survivors.
The Predictive Value of the Fibrinogen–Albumin-Ratio Index on Surgical Outcomes in Patients with Advanced High-Grade Serous Ovarian Cancer
Authors: Postl Magdalena , Danisch Melina , Schrott Fridolin , Kofler Paul , Petrov Patrik , Aust Stefanie , Concin Nicole , Polterauer Stephan , Bartl Thomas
Published: September 2024

Background/Objectives: The present study evaluates predictive implications of the pretherapeutic Fibrinogen–Albumin-Ratio Index (FARI) in high-grade serous ovarian cancer (HGSOC) patients undergoing primary cytoreductive surgery. Methods: This retrospective study included 161 patients with HGSOC International Federation of Gynecology and Obstetrics (FIGO) stage ≥ IIb, who underwent primary cytoreductive surgery followed by platinum-based chemotherapy. Associations between the FARI and complete tumor resection status were described by receiver operating characteristics, and binary logistic regression models were fitted. Results: Higher preoperative FARI values correlated with higher ascites volumes (r = 0.371, p < 0.001), and higher CA125 levels (r = 0.271, p = 0.001). A high FARI cut at its median (≥11.06) was associated with lower rates of complete tumor resection (OR 3.13, 95% CI [1.63–6.05], p = 0.001), and retrained its predictive value in a multivariable model independent of ascites volumes, CA125 levels, FIGO stage, and Charlson Comorbidity Index (CCI). Conclusions: The FARI appears to act as a surrogate for higher intra-abdominal tumor load. After clinical validation, FARI could serve as a readily available serologic biomarker to complement preoperative patient assessment, helping to identify patients who are likely to achieve complete tumor resection during primary cytoreductive surgery.
Correction: Sato et al. Safety of Boron Neutron Capture Therapy with Borofalan(10B) and Its Efficacy on Recurrent Head and Neck Cancer: Real-World Outcomes from Nationwide Post-Marketing Surveillance. Cancers 2024, 16, 869
Authors: Sato Mariko , Hirose Katsumi , Takeno Satoshi , Aihara Teruhito , Nihei Keiji , Takai Yoshihiro , Hayashi Toshimitsu , Bando Kosuke , Kimura Hitomi , Tsurumi Keisuke , Ono Koji
Published: September 2024

The authors wish to make the following corrections to this paper [...]
ANKRD1 Promotes Breast Cancer Metastasis by Activating NF-κB-MAGE-A6 Pathway
Authors: Diskul-Na-Ayudthaya Penchatr , Bae Seon Joo , Bae Yun-Ui , Van Ngu Trinh , Kim Wootae , Ryu Seongho
Published: September 2024

Early detection and surgical excision of tumors have helped improve the survival rate of patients with breast cancer. However, patients with metastatic cancer typically have a poor prognosis. In this study, we propose that ANKRD1 promotes metastasis of breast cancer. ANKRD1 was found to be highly expressed in the MDA-MB-231 and MDA-LM-2 highly metastatic breast cancer cell lines compared to the non-metastatic breast cancer cell lines (MCF-7, ZR-75-30, T47D) and normal breast cancer cells (MCF-10A). Furthermore, high-grade tumors showed increased levels of ANKRD1 compared to low-grade tumors. Both in vitro and in vivo functional studies demonstrated the essential role of ANKRD1 in cancer cell migration and invasion. The previous studies have suggested a significant role of NF-κB and MAGE-A6 in breast cancer metastasis, but the upstream regulators of this axis are not well characterized. Our study suggests that ANKRD1 promotes metastasis of breast cancer by activating NF-κB as well as MAGE-A6 signaling. Our findings show that ANKRD1 is a potential therapeutic target and a diagnostic marker for breast cancer metastasis.
First-Line Use of Daratumumab in Patients with Multiple Myeloma Shows Delayed Neutrophil and Platelet Engraftment after Autologous Stem Cell Transplantation: Results from a Real-Life Single-Center Study
Authors: Martino Massimo , Gori Mercedes , Porto Gaetana , Policastro Giorgia , Pitea Martina , Sgarlata Annalisa , Delfino Ilaria Maria , Cogliandro Francesca , Scopelliti Anna , Utano Giovanna , Pellicano Maria , Idato Aurora , Vincelli Iolanda Donatella , Marafioti Violetta , Micò Maria Caterina , Lazzaro Giuseppe , Loteta Barbara , Alati Caterina , Leanza Giovanni , D’Arrigo Graziella , Tripepi Giovanni Luigi , Pitino Annalisa
Published: September 2024

Background: This real-life study aimed to investigate the possible impact of D-VTd induction therapy on hematopoietic engraftment after autologous stem cell transplantation (auto-SCT). Methods: Sixty consecutive NDMM patients received four cycles of induction therapy with D-VTd. The conditioning regimen consisted of melphalan 200 mg/m2. These patients were compared with a historical control group of 80 patients who received four cycles of VTd as induction therapy. Results: The median days to reach neutrophil and platelet engraftment significantly differed between patients treated with D-VTd (11 and 13 days, respectively) and VTd (10 and 12 days). Univariate Cox analyses show that patients treated with D-VTd had a hazard ratio of neutrophil engraftment that was 42% significantly lower than those in the VTd arm (HR: 0.58, p = 0.002), and a multivariate model confirmed this result. Patients treated with D-VTd developed FN more frequently. Univariate and multivariate logistic regressions revealed an association between D-VTd and FN. Delayed engraftment did not correlate with more extended hospitalization. No patients died in the first six months after transplantation. Conclusions: Our real-life study showed that a four-drug induction therapy containing DARA does not impact transplant safety outcomes.