bluuebunny/crossref_metadata_2025 huggingface dataset:
The Experience of Inspiration in Natural Landscapes: Awe, Wonder, Sublimity, and Bergson's Qualitative Multiplicity
Authors: Shores Jim , Daniel Brad , Faircloth W. Brad
Published: October 2023

Background: As a psychological construct, inspiration has not received extensive examination in the outdoor literature. Inspiration can be characterized in terms of evocation, motivation, and transcendence. Purpose: This qualitative study explored the experience of inspiration in response to natural landscapes utilizing Bergson's qualitative multiplicity, the experience of co-occurring heterogeneous elements. Methodology/Approach: Survey respondents participated in a traveling field course visiting 19 U.S. National Parks in 2015 ( n = 15, 26 days) and 14 parks in 2017 ( n = 15, 18 days). Respondents described inspirational experiences in each park. Findings/Conclusions: Qualitative analysis of responses revealed a characteristic pattern: landscape features, landscape qualities, and affective responses. Participants cited vertical features, vastness, and beauty as triggers of inspiration, and characterized inspiration in terms of awe, wonder, and sublimity. Implications: This study describes inspiration in the outdoors, with implications for planning direct experiences of natural landscapes to maximize inspiration.
Sulbactam-Durlobactam in the Treatment of Carbapenem-Resistant Acinetobacter baumannii Infections
Authors: August Benjamin , Matlob Andrew , Kale-Pradhan Pramodini B.
Published: October 2023

Objective:

To review the pharmacology, efficacy, and safety of intravenous sulbactam-durlobactam (SUL-DUR) in the treatment of carbapenem-resistant Acinetobacter baumannii (CRAB) infections.

Data Sources:

PubMed databases and ClinicalTrials.gov were searched using the following terms: Sulbactam Durlobactam, ETX2514, Xacduro, Sulbactam-ETX2514, ETX2514SUL.

Study Selection and Data Extraction:

Articles published in English between January 1985 and September 13, 2023, related to pharmacology, safety, efficacy, and clinical trials were reviewed.

Data Synthesis:

A phase II trial compared SUL-DUR with placebo with imipenem and cilastatin in both groups. Overall treatment success in the microbiological intention-to-treat analysis was reported in 76.6% of patients in the SUL-DUR group compared with 81% patients in the placebo group. A phase III trial compared SUL-DUR with colistin in adults with confirmed CRAB infections. Patients received either SUL-DUR or colistin and background therapy with imipenem-cilastatin. SUL-DUR was noninferior to colistin for 28-day all-cause mortality (19% vs 32.3%, treatment difference −13.2%; 95% CI [−30.0 to 3.5]).

Relevance to Patient Care and Clinical Practice in Comparison to Existing Drugs:

Clinicians have limited options to treat CRAB infections. SUL-DUR has demonstrated efficacy against CRAB in patients with pneumonia and may be considered a viable treatment option. Nonetheless, potential impact of concomitant imipenem-cilastatin as background therapy on clinical trial findings is unclear. Further studies are needed to elucidate the role of SUL-DUR alone or in combination with other active antimicrobials for the treatment of CRAB infections.

Conclusions:

SUL-DUR has shown to be predominantly noninferior to alternative antibiotics in the treatment of pneumonias caused by CRAB, making it a viable treatment option. Further postmarketing data is needed to ascertain its role in other infections.
Understanding Trauma: A Primer for Developing a Trauma-Focused Lens in Schools
Authors: Bland Kevin D. , Gershwin Tracy
Published: October 2023

According to research, as many as 68% of students have experienced at least some form of trauma (Cavanaugh, 2016). Yet, most educators report feeling inadequate about understanding trauma-informed practice, including understanding how trauma can impact student behavior in the classroom. This article provides a primer about trauma that can allow educators to unpack the definition, understanding, identification, and the impact traumatic experiences can have on students in today’s schools.
Using the Colaizzi Method to Explore Intimate Partner Violence Caseworkers’ Subjective Experience: Pathways to Intimate Partner Violence Work and What Keeps Them Going
Authors: Allman Madeleine , Nava Angeles , Asim Nabeeha , Brashear Barbie , Walton Quenette L. , McFarlane Judith , Sharp Carla
Published: October 2023

Successful intimate partner violence (IPV) safety, advocacy, and intervention programs require recruitment and retention of persons of experience and commitment. To examine lived experiences of IPV advocates working in transitional shelter programs for women exiting IPV relationships, focus group discussions of 15 transitional housing and IPV shelter caseworkers were analyzed using the Colaizzi seven-step phenomenological method of analysis. Several themes emerged through the analysis, including historical, intergenerational pathways to IPV work and unity in sisterhood with IPV clients. The seven-step Colaizzi method is presented with examples of how each Colaizzi step yields an understanding of what motivates and sustains IPV caseworkers.
Comparison between intravitreal brolucizumab and aflibercept in the treatment-naive central involved diabetic macular edema: One-year real-life case series
Authors: Elhamaky Tarek Roshdy
Published: October 2023

Purpose

To evaluate the effectiveness and safety of intravitreal brolucizumab (IVB) and intravitreal aflibercept (IVA) injections in the management of naive central involved diabetic macular edema (CIDME).

Methods

This study included 45 treatment-naive eyes with CIDME. A complete ophthalmic examination, including BCVA and SD-OCT was performed. Patients were randomized to (IVB) or (IVA) groups. All participants received a loading phase of three consecutive intravitreal injections, then followed by a personalized treat and extend (T&E) regimen.

Results

At 12-month follow-up, the mean numbers of injections in IVA and IVB groups were 7.25  ±  0.53 and 6.3  ±  0.45, respectively (P < 0.0001). The IVA group showed a significant increase of the mean BCVA from 0.66  ±  0.15 logMAR (50.9  ±  7.7 letters) to 0.41  ±  0.19 logMAR (63.7  ±  10.8 letters). Mean CFT decreased significantly from 441.2  ±  35.7 μm to 281.3  ±  18.4 μm. The IVB group showed a significant increase of mean BCVA from 0.65  ±  0.16 logMAR (52.1  ±  7.9 letters) to 0.39  ±  0.17 logMAR (65.3  ±  8.7 letters). Mean CFT decreased significantly from 437.2  ±  41.9 μm to 275.5  ±  21.7 μm. No significant difference between both groups in terms of the vision improvement and the reduction of CFT was reported, whereas a statistical difference was observed in terms of intravitreal injections (IVI) numbers. No ocular complications were reported.

Conclusions

This case series highlights the effectiveness of both brolucizumab and aflibercept in the treatment of CIDME with a lower frequency of injection in brolucizumab group lowering the burden of IVI in this cohort.
Ocular toxoplasmosis following anti-tumour necrosis factor-α therapy combined with oral methotrexate therapy: A case report and review of literature
Authors: Patnaik Gazal , Pyare Richa , Kaushik V V , Dutta Majumder Parthopratim
Published: October 2023

Purpose: To report a case of ocular toxoplasmosis following long-term treatment with adalimumab and review the literature on ocular toxoplasmosis following anti-Tumour necrosis factor-α therapy. Method: A retrospective chart review of A 21-year-old male who developed retinochoroiditis in his left eye following adalimumab therapy combined with oral methotrexate. Result: A known patient of juvenile idiopathic arthritis (JIA) on adalimumab and oral methotrexate for the last four years presented to us with a blurring of vision for the last 15 days. Fundus examination of the left eye revealed severe vitritis and two patches of retinochoroiditis in the inferior part of the fundus. Subsequent investigations confirmed it to be a case of toxoplasma retinochoroiditis, and he responded to anti-toxoplasma treatment. A review of literature on a similar topic revealed five such cases, and the index case was the first such report in patients with JIA. Conclusion: The index case highlights the importance of early recognition and management of opportunistic infections in patients receiving biologicals.
Changes in vascular access profile for pediatric hemodialysis patients over time: A registry-based study from Catalonia
Authors: Roca-Tey Ramon , Ariceta Gema , Ríos Héctor , Cruz Alejandro , Comas Jordi , Tort Jaume
Published: October 2023

Background:

The criteria for vascular access (VA) selection in pediatric hemodialysis (HD) population has changed over time until the current patient-centered approach using the individualized Life-Plan. We analyzed the type of VA used by incident and prevalent end-stage kidney disease (ESKD) pediatric patients (pts) treated with HD in Catalonia.

Method:

Data from the Catalan Renal Registry of ESKD pts under 18 years of age undergoing kidney replacement therapy (KRT) were examined for a 22-year period (1997–2018).

Results:

ESKD children starting KRT through HD decreased progressively from 55.6% (1997–2001) to 38.2% (2012–2018) and, conversely, there was an increase in pts starting KRT by preemptive kidney transplantation (KT) from 28.9% to 42.6% between the same periods (for both comparisons, p = 0.007). Most ESKD pts started HD by fistula (AVF) from 1997 to 2001 (56.5%) but this percentage decreased over time and no AVFs were used to start HD in children from 2012 to 2018. Likewise, the percentage of children starting HD by tunneled catheter increased progressively from 8.7% to 72.2% between the same periods (for both comparisons, p < 0.001). Regarding prevalent ESKD pts, children on HD decreased from 34.9% in 1997 to 4.7% in 2018 and, conversely, pts with a functioning kidney graft increased from 62.8% to 92.4% during the same periods (for both comparisons, p < 0.001). There was a progressive decrease in the percentage of children dialyzed by AVF from 100% in 1997 to 0% in 2018 ( p < 0.001). The KT rate increased from 5.4 per million population (pmp) in 1997 to 17.1 pmp in 2018 ( p = 0.007). The median time on HD prior to the first KT progressively decreased to 6.6 months (2014–2018).

Conclusion:

The high KT rate was a determining factor in choosing the VA type in the incident and prevalent pediatric population treated with HD in Catalonia.
Performance comparison of measurement microphones and microbarometers for sound pressure measurements near wind power plants
Authors: Rust Marvin , Koch Christian
Published: October 2023

Reliable assessment of airborne infrasound emitted by natural and technical sources has been gaining importance, while technology is limited and regulations are not sufficient in the infrasound frequency range. This paper provides a comparison of measurement microphones and microbarometers used for infrasound measurements in the field near wind power plants. Simultaneous measurements with both sensor systems were conducted at multiple sites in the vicinity of a wind park. Based on these measurements, it was shown that wind-induced noise is a major concern when measuring infrasound in the field. For this reason, additional experiments were conducted in an aeroacoustic wind tunnel to further investigate the sensitivity to wind of the sensors used. A combination of field measurements and laboratory experiments was applied to determine the influence of wind-induced noise in a real-life situation and multiple strategies are discussed for establishing quality criteria and controlling the influence of wind on such measurements.
The nuances of network sovereignty: A collaborative study of the Internet and ICTs in the Blackfeet community in Montana
Authors: Parks Lisa , Wisseh Assatu , DuCharme Gaylene , DesRosier Sarah
Published: October 2023

Building on research on network sovereignty in American Indian communities, this study explores how the Internet and information and communication technologies (ICTs) are imagined and used by members of the Blackfeet community in Montana. Using qualitative mixed methods, including interviews with 38 Blackfeet community members, the study provides a brief overview of the Siyeh Corporation’s Internet services in Blackfeet territory and presents a thematic analysis of interview data focused on three issues: the Internet as a daily lifeline; peoples’ ideals and standards of sovereignty; and tensions around network sovereignty. The article explores how Blackfeet community members assess their tribe’s moves to assert network sovereignty, presenting a range of opinions regarding tribally owned and operated Internet services. Building from interview data, the article suggests that practices and perceptions of local tribal governance are vital to mounting and sustaining meaningful network sovereignty initiatives.
The Emerging Role of Exosomal miRNAs as Biomarkers for Early Cancer Detection: A Comprehensive Literature Review
Authors: Jafari Ali , Karimabadi Keyvan , Rahimi Aso , Rostaminasab Gelavizh , Khazaei Mozafar , Rezakhani Leila , Ahmadi jouybari Touraj
Published: October 2023

A significant number of cancer-related deaths are recorded globally each year, despite attempts to cure this illness. Medical science is working to develop new medication therapies as well as to find ways to identify this illness as early as possible, even using noninvasive techniques. Early detection of cancer can greatly aid its treatment. Studies into cancer diagnosis and therapy have recently shifted their focus to exosome (EXO) biomarkers, which comprise numerous RNA and proteins. EXOs are minuscule goblet vesicles that have a width of 30 to 140 nm and are released by a variety of cells, including immune, stem, and tumor cells, as well as bodily fluids. According to a growing body of research, EXOs, and cancer appear to be related. EXOs from tumors play a role in the genetic information transfer between tumor and basal cells, which controls angiogenesis and fosters tumor development and spread. To identify malignant activities early on, microRNAs (miRNAs) from cancers can be extracted from circulatory system EXOs. Specific markers can be used to identify cancer-derived EXOs containing miRNAs, which may be more reliable and precise for early detection. Conventional solid biopsy has become increasingly limited as precision and personalized medicine has advanced, while liquid biopsy offers a viable platform for noninvasive diagnosis and prognosis. Therefore, the use of body fluids such as serum, plasma, urine, and salivary secretions can help find cancer biomarkers using technologies related to EXOs.
Use of the neuroform atlas for stenting of intracranial atherosclerotic disease: Clinical and angiographic outcomes
Authors: Ellenbogen Yosef , Hendriks Eef J , Karadimas Spyros , O’Reilly Sean , Itsekzon Hayosh Zeev , Alshahrani Rabab , Agid Ronit , Schaafsma Joanna , Krings Timo , Nicholson Patrick
Published: October 2023

Background

Intracranial atherosclerotic disease (ICAD) is a potential cause of ischemic stroke. Treatment of ICAD can include intracranial stenting. There are specifically designed stents for this use-case; however, less is known about the off-label use of the Neuroform Atlas stent. In this study, we describe the outcomes of the Neuroform Atlas stent for treatment of ICAD.

Methods

Adult patients with symptomatic ICAD failing best medical treatment undergoing elective intracranial stenting using the Neuroform Atlas stent between November 2018 and March 2021 were included. Patient demographics, procedure-related details and clinical and imaging outcomes were analyzed.

Results

Eighteen patients met the inclusion criteria, with a mean follow-up duration of 9.6 ± 6.8 (standard deviation) months. There were two procedure-related mortalities (one massive intracranial hemorrhage and one groin site complication with sepsis). Fifteen patients were alive at the 6-month follow-up, all with satisfactory stent patency on follow-up imaging without any new ischemic events. Modified Rankin Scale at latest follow-up was 1.9 (interquartile range 5).

Conclusion

In this single-center consecutive series, intracranial stenting with the Neuroform Atlas stent was a safe and effective treatment for symptomatic ICAD patients failing best medical management.
Contingency learning and episodic contributions to the item-specific proportion congruent effect
Authors: Gallego David , Méndez Castor , Jiménez Luis
Published: October 2023

Several studies have challenged the conflict adaptation account of cognitive control effects, suggesting that they are the result of learning/memory processes independent from control modulation. Some authors have suggested that the item-specific proportion congruent (ISPC) effect (i.e., the smaller congruency effect on items presented frequently in an incongruent combination) is driven by colour–word contingency learning (CL). However, it has recently been suggested that CL can be explained in terms of episodic retrieval of the response given to the last encounter with the same stimulus, with no role of associative learning. This study aims to analyse the independent role of CL and episodic retrieval on the ISPC effect. Experiment 1 showed no effect of control modulation and indicated that, when manipulated independently, learning-driven contingency is modulated by the episodic factor, but it remains significant. Experiments 2 and 3 extended the study of the interplay between learning and recency to the colour–word CL paradigm, finding larger contingency effects on colour words compared with neutral ones and replicating the interaction between CL and episodic retrieval from Experiment 1. Surprisingly, these two experiments also showed control modulation apart from contingency and recency effects in colour words. In sum, our study reveals that the ISPC effect results from the joint contribution of cognitive control, associative learning, and episodic effects.
Memories of a fishing landscape: Making sense of flow and decline
Authors: Abranches Maria
Published: October 2023

Drawing on life history interviews conducted with former fishers and other older residents in Great Yarmouth – one of the 20% most deprived districts in England – this article explores how memories of a once flourishing fishing industry are used to make sense of the decline that followed the end of the industry in the 1960s. Focusing on the material and affective constituents of people’s memories, embodied in three categories of fishing-related objects (boats and quay, nets and fish) through which their stories are told, I explore how those formerly involved in fishing-related activities understand and experience the past and their world in the present. Using biographical and historical memories to reclaim their role in the making of a town that they consider to ‘have missed the boat’, they are able to make sense of the transformations that occurred and to reclaim their role as place makers.
A Systematic Review of the Research: The Self-Determined Learning Model of Instruction Within MTSS
Authors: Matusevich Hunter A. , Shogren Karrie A. , Raley Sheida K. , Zimmerman Kathleen N. , Alsaeed Abdulaziz , Chapman Richard
Published: October 2023

Self-determination is a predictor of postschool success. The importance of self-determination instruction for students with and without disabilities is increasingly being recognized. The Self-Determined Learning Model of Instruction (SDLMI) has been implemented in various settings and at various intensities with all students. Researchers have suggested a multi-tiered system of support (MTSS) framework could be used to organize self-determination instruction for all students. However, a systematic literature review to inform SDLMI implementation within MTSS has not been conducted. This systematic review examined intervention research, synthesizing key features that could inform ongoing research and practice applying an MTSS framework to self-determination instruction. Limitation and implications for research and practice are described.
Resisting Legacies of Racialized Adversities: Counterstories of South Asians Navigating Transition Planning
Authors: Shikarpurya Sehrish , Gilson Carly B.
Published: October 2023

Strengthening parent support is critical to improving the transition to adulthood outcomes of racially minoritized youth. However, in literature, the transition experiences of racially minoritized parents are often characterized using deficit-based language. Strengths-based counternarratives of racially minoritized parents could offer a broader account of parent experiences. We conducted a pilot sequential explanatory transformative mixed methods design with equal priority to capture the adversities experienced and the strengths leveraged by South Asian parents in the United States. When navigating the transition planning process. We used the strengths-based frameworks of community cultural wealth and counterstories to reframe and re(present) the transition experiences of South Asian parents. Specifically, we blended quantitative ( N = 46) and qualitative findings ( N = 8) to develop a preliminary meta-inference of the transition experiences of South Asian parents. We discuss the implications of our findings for research and practice.
China’s pandemic-time public diplomacy in the Balkans and the challenge to the EU’s regional leadership
Authors: Ushkovska Mare
Published: October 2023

This paper explores how China’s assistance to countries in the Western Balkans during the pandemic boosted their reputation in the region, through the case studies of Serbia, Macedonia, and Albania. The COVID-19 crisis has tested EU’s reputation of solidarity and partnership to the Western Balkans, with Balkan political leaders accusing the bloc of selfishness due to its decision in 2020 to restrict exports of medical equipment to candidate states and the perceived neglect of the region during the vaccine distribution in early 2021. Simultaniously, China sent planes containing tonnes of medical supplies, respirators, medical personnel, and later vaccines, that would be received with great pomp and live media coverage, in a powerful public diplomacy and vaccine diplomacy offensive. This paper argues that this helped improve public opinion and reshape narratives on China in the Western Balkans. Still, attitudes vary between states, with Serbians having the most favourable views on China as a foreign partner. On the other hand, while public perceptions on China have seen a positive shift in Macedonia and Albania, this has not translated in a change in their pro-EU stance.
Sustainable Development Goals in Ireland: How Public Health Nurses Are Contributing Through Engagement in an Interagency Community Pediatric Clinic
Authors: Buckley Lynn , Gibson Louise , Harford Katherine , Cornally Nicola , Curtin Margaret
Published: October 2023

Introduction

United Nations Sustainable Development Goals (SDGs) were adopted as a plan of action for people, planet, and prosperity by 2030. SDG 3 aims to ensure healthy lives and promote well-being for all ages, and other goals focus on reduction of inequality, abolition of poverty, decent work for all, and building effective, accountable, and inclusive institutions. A community pediatric clinic, Kidscope, was established in a vulnerable Irish community offering free developmental assessment and onward referral of children 0 to 6 years. The Kidscope model involves multiagency input with local public health nurses (PHNs) acting as fundamental partners in the provision of specialist early years support to vulnerable children and families. This study evaluates PHN involvement in Kidscope in the context of SDGs.

Objective

To record and understand PHN roles within Kidscope and to capture their contribution to achieving SDGs in a disadvantaged Irish community.

Methods

Qualitative stakeholder analysis and mapping design. Snowball sampling identified participants. Data collection involved scoping interviews, questionnaires, one-to-one interviews, and a focus group. A Stakeholder Matrix Table was developed in line with the guiding framework. Transcripts were thematically analyzed.

Results

PHNs are key stakeholders in Kidscope contributing to clinic development, delivery, and sustainability. Six themes were identified: lead referrers, in-clinic support, learning and education, child and family follow-up, specialist early years role, and partnership working. PHNs contribute to six SDGs through the Kidscope model.

Conclusion

PHNs are fundamental partners in achieving SDGs in a disadvantaged Irish community through ameliorating childhood developmental delay by intercepting the gap within Ireland's early intervention system and disrupting the impact exclusion to healthcare has on vulnerable children and their families. Findings underscore a shift from the current “cradle to grave” model of working toward a specialist early years PHN role.
From network analysis to experimental validation: identification of regulators of non-muscle myosin II contractility using the folded-gastrulation signaling pathway
Authors: Zhao Andy , Varady Sophia , O’Kelley-Bangsberg Madelyn , Deng Vicki , Platenkamp Amy , Wijngaard Petra , Bern Miriam , Gormley Wyatt , Kushkowski Elaine , Thompson Kat , Tibbetts Logan , Conner A. Tamar , Noeckel David , Teran Aidan , Ritz Anna , Applewhite Derek A.
Published: October 2023

The morphogenetic process of apical constriction, which relies on non-muscle myosin II (NMII) generated constriction of apical domains of epithelial cells, is key to the development of complex cellular patterns. Apical constriction occurs in almost all multicellular organisms, but one of the most well-characterized systems is the Folded-gastrulation (Fog)-induced apical constriction that occurs in Drosophila. The binding of Fog to its cognizant receptors Mist/Smog results in a signaling cascade that leads to the activation of NMII-generated contractility. Despite our knowledge of key molecular players involved in Fog signaling, we sought to explore whether other proteins have an undiscovered role in its regulation. We developed a computational method to predict unidentified candidate NMII regulators using a network of pairwise protein–protein interactions called an interactome. We first constructed a Drosophila interactome of over 500,000 protein–protein interactions from several databases that curate high-throughput experiments. Next, we implemented several graph-based algorithms that predicted 14 proteins potentially involved in Fog signaling. To test these candidates, we used RNAi depletion in combination with a cellular contractility assay in Drosophila S2R + cells, which respond to Fog by contracting in a stereotypical manner. Of the candidates we screened using this assay, two proteins, the serine/threonine phosphatase Flapwing and the putative guanylate kinase CG11811 were demonstrated to inhibit cellular contractility when depleted, suggestive of their roles as novel regulators of the Fog pathway.
Equitable access to COVID-19 diagnostics: factors associated with the uptake of rapid antigen testing in Victoria, Australia, January – February 2022
Authors: McCormick Erica , Hales Gabrielle , Ampt Frances , Alpren Charles
Published: October 2023

Background

Accessible and accurate diagnostics are critical to control communicable diseases. Uptake of COVID-19 rapid antigen (RA) testing requires physical and financial access to tests, knowledge about usage, motivation, and ability to report results. We sought to understand patterns of and factors associated with RA test uptake in Victoria during a period of high caseload, RA test promotion, and difficulty accessing RA and PCR testing. We hypothesise RA test uptake is indicated by the ratio of cases diagnosed by RA test (probable) to those diagnosed using PCR (confirmed) (p:c).

Methods

Analysing case records, trends in p:c were assessed, between regions, sex, age groups, socio-economic strata and cultural diversity. Logistic regression assessed associations between case classification, and median age, postcode-level socio-economic disadvantage, and proportion overseas-born.

Results

We included 591,789 cases. Mean p:c was lower in socio-economically disadvantaged areas (decile 1 + 2: 0.90 vs. decile 9 + 10: 1.10), and in postcodes where the overseas-born population was above the Victorian average (0.83 vs. 1.05). Conversely, p:c was higher in younger age groups; with no difference between sexes overall. In metropolitan Melbourne, odds of RA test usage increased as socio-economic disadvantage decreased (decile 9 + 10, aOR 1.40, 95%CI 1.37–1.43, vs. decile 1 + 2; p < .001), decreased for cases from areas with a higher overseas-born population (aOR 0.85, 0.83–0.86, p < .001), and with older age.

Conclusions

Reduced uptake of RA tests in Victoria is associated with socio-economic disadvantage, cultural diversity, and older age. Equitable access to COVID-19 diagnostics requires elimination of financial barriers, and greater engagement with culturally diverse and older groups. Inequitable RA test uptake may lead to case under-ascertainment, affecting resource allocation, effective control strategy development, in turn impacting COVID-19 morbidity and mortality, and could indicate relative engagement with response initiatives.
Assessment of resources for physical activity and understanding people’s perception and practices regarding physical activity in an Indian city
Authors: Gautam Susheel , B N Kruthika , Akashanand  , Roy Aaheli , Banandur Pradeep S. , Anniappan Banavaram Arvind
Published: October 2023

Background

Promoting physical activity in urban India is imperative considering the burden of non-communicable diseases in the country. Planning for improving population level physical activity needs sound understanding of availability and quality of resources/facilities for physical activity and knowing people’s perception and practices regarding the physical activity.

Methods

A cross-sectional study was undertaken in Kolar city of Karnataka state in India. All the resources/facilities required for supporting physical activity were mapped and their quality was assessed utilizing adapted version of physical activity resource assessment questionnaire. The information regarding latitude, longitude and approximate size of the resource was obtained using a hand-held GPS tracker. 495 individuals aged ≥ 18 years, selected by two stage cluster random sampling with probability proportionate to population size technique, were interviewed to assess their perception and practices regarding physical activity using semi-structured questionnaire and global physical activity questionnaire.

Results

Kolar city has 36.3 physical activity resources per lakh population and per person availability of park and playground area was 0.4 Sq. meters. Available resources were concentrated in the center of the city. Half of the sports facilities and 14 of the 17 recreational facilities in the city were of poor to mediocre quality. 38.2% of adults in Kolar city were found to be physically active. Only 19.2% of the study participants had accessed sports/fitness facilities/playgrounds in past 3 months and only 18.8% of the study participants accessed parks in the previous 3 months. 28.6% to 59.1% of the participants preferred ‘walking’ for work, college and shopping. Less than 5% of the participants preferred and used cycle as a mode of transport. 1/3rd of the study participants felt that Kolar city is safe of walking and 44.6% felt that the city is safe for cycling.

Conclusion

Creating enabling environment by increasing the number and quality of resources/facilities for physical activity along with their equitable distribution is required to promote and improve population level physical activity in Kolar city. Urban planning with a focus on non-motorized transport including walking would contribute to improved people’s perception and practices regarding physical activity in the city.
Autoimmune thyroid status in subclinical thyroid disorders in patients attending a tertiary care center in Nepal: a hospital-based cross-sectional study
Authors: Sharma Vijay Kumar , Niraula Apeksha , Tuladhar Eans Tara , Bhattarai Aseem , Raut Mithileshwer , Dubey Raju Kumar , Baidya Sujata , Parajuli Naresh
Published: October 2023

Background

Thyroid dysfunction is the leading endocrine disorder worldwide. Iodine deficiency disorders, which were once the major etiology of thyroid dysfunctions, now have been succeeded by autoimmune thyroid diseases with the rise in aberrant salt ionization protocols. This study endeavors to access the level of thyroid autoantibodies viz. anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (TGA), and anti-thyroid stimulating hormone receptor (TRAb) in individuals with subnormal thyroid profiles.

Methods

This hospital-based cross-sectional study was conducted at the Department of Clinical Biochemistry, Tribhuvan University for a period of six months. Using non-probability (purposive) sampling method, a total of 60 patients were enrolled with subnormal thyroid profiles to include the population who have not yet started medication. Thyroid hormones (free T3, free T4, TSH) and thyroid antibodies (anti-TPO, TGA, and TRAb) were measured. For non-parametric data, Chi-square test and Kruskal-Wallis test were used. Spearman’s correlation was done to determine the association between variables.

Results

Out of 60 participants, the majority of the population between 25 and 44 years were diagnosed with thyroid dysfunction with female preponderance. Among all, 40% (n = 24) had subclinical hyperthyroid states while, 60% (n = 36) had subclinical hypothyroid states, and 75% (n = 45) of the total exhibited positive thyroid antibodies. In subclinical hypothyroid patients with TSH above 10 µIU/ml, anti TPO (58.5%) and TGA (66.7%) positivity were highly prevalent. On the other hand, TRAb was exclusively positive in hyperthyroid condition (50% among the group) which is by far the first of its kind reported in Nepal.

Conclusion

The rise in autoimmune thyroid disease among the Nepalese population infers that addressing iodine deficiency simply through salt iodinization may not be adequate to deal with the rising burden of thyroid disorders, especially in iodine-depleted areas. Also, the increasing prevalence of thyroid autoantibodies positivity in subclinical hypothyroidism in the Nepalese population accounts for the arduous screening and monitoring of autoimmune thyroid disorders in Nepal.
Endeavouring interplay: a grounded theory study of how nurse educators’ work with simulation-based learning
Authors: Røykenes Kari , Kvernenes Monika , Giske Tove
Published: October 2023

Background

Simulation-based learning is frequently used as a teaching and learning strategy in nursing and other health professions educations, and educators have a key role as facilitators. This facilitator role provides them with a particularly relevant perspective to help us understand and theorize around the essence of simulation-based learning, and how it is approached. This study aims to explore nurse educators’ experiences and strategies in simulation-based learning.

Method

Data were collected in 2018-2021 using in-depth interviews with eight nurse educators. Transcripts were analysed through constant comparison using Classical Grounded Theory approach.

Result

The participants' main concern was how to Maximize students' learning-space in simulation. To resolve this, four strategies were identified: legitimizing simulation, self-development, preparing students, and tailoring simulation. Legitimisation, and self-development were found to be important prerequisites for developing the learning space and were therefore defined as the background or context of the theory. Nurse students were the focus of the two remaining categories, preparing students and tailoring simulation, and are thus defined as being in the foreground of the theory. The dynamics of these four strategies were captured in the Grounded theory of Endeavouring interplay.

Conclusion

The theory of Endeavouring interplay illustrates the complexity educators are encountering when aiming to optimize simulation as a learning space for nurse students. The strategies used are adapted to the organisational climate, available resources and context, and include striving to legitimize simulation, pursue self-development in the role as facilitator, help students prepare for simulation-based learning, and tailor the simulation to both contextual factors and individual student needs.
AP4M1 as a prognostic biomarker associated with cell proliferation, migration and immune regulation in hepatocellular carcinoma
Authors: Peng Yuanhao , Li Xuanxuan , Kang Kuo , Zhou Yangying
Published: October 2023

Background

AP4M1 is a protein-coding gene that plays a crucial role in transporter activity, recognition, and hereditary-associated diseases, but it’s largely unknown in cancers.

Methods

The expression level of AP4M1 in cancers was investigated by The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, and the correlation between AP4M1 and hepatocellular carcinoma (HCC) clinicopathological parameters were analyzed. Univariate and multifactorial COX regression analyses were performed to clarify the prognostic value of AP4M1 in HCC. The correlation between AP4M1 and immune cell infiltration was analyzed using single-sample Gene Set Enrichment Analysis (ssGSEA). Besides, we verified the biological function of AP4M1 by applying Cell Counting Kit-8 (CCK8), colony formation, and transwell assays.

Results

The expression of AP4M1 was significantly elevated in HCC and was correlated with patients’ pathological grades, AFP, and BMI. Kaplan-Meier survival curves indicated that patients with AP4M1 overexpression had worse overall survival. Univariate and multivariate COX regression analyses showed that AP4M1 was an independent risk factor affecting the prognosis of HCC. In addition, we observed that AP4M1 positively correlated with most immune checkpoint suppressor genes in HCC. Moreover, in vitro experiments further confirmed that AP4M1 could promote the proliferation and invasion of HCC.

Conclusions

AP4M1 is highly expressed and associated with poor prognosis in HCC. AP4M1 is closely related to cancer-immune regulation and could be a novel target for HCC, and guiding new strategies for the diagnosis and treatment of HCC patients.
Proteomic analysis of neonatal mouse hearts shows PKA functions as a cardiomyocyte replication regulator
Authors: Hu Lizhi , Liang Minglu , Jiang Qin , Jie Youming , Chen Long , Zhang Fengxiao
Published: October 2023

The ability of the adult mammalian heart to regenerate can save the cardiac muscle from a loss of function caused by injury. Cardiomyocyte regeneration is a key aspect of research for the treatment of cardiovascular diseases. The mouse heart shows temporary regeneration in the first week after birth; thus, the newborn mouse heart is an ideal model to study heart muscle regeneration. In this study, proteomic analysis was used to investigate the differences in protein expression in the hearts of neonatal mice at days 1 (P1 group), 4 (P4 group), and 7 (P7 group). Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed changes in several groups of proteins, including the protein kinase A (PKA) signaling pathway. Moreover, it was found that PKA inhibitors and agonists regulated cardiomyocyte replication in neonatal mouse hearts. These findings suggest that PKA may be a target for the regulation of the cardiomyocyte cell cycle.
A robot-based interception task to quantify upper limb impairments in proprioceptive and visual feedback after stroke
Authors: Park Kayne , Ritsma Benjamin R. , Dukelow Sean P. , Scott Stephen H.
Published: October 2023

Background

A key motor skill is the ability to rapidly interact with our dynamic environment. Humans can generate goal-directed motor actions in response to sensory stimulus within ~ 60-200ms. This ability can be impaired after stroke, but most clinical tools lack any measures of rapid feedback processing. Reaching tasks have been used as a framework to quantify impairments in generating motor corrections for individuals with stroke. However, reaching may be inadequate as an assessment tool as repeated reaching can be fatiguing for individuals with stroke. Further, reaching requires many trials to be completed including trials with and without disturbances, and thus, exacerbate fatigue. Here, we describe a novel robotic task to quantify rapid feedback processing in healthy controls and compare this performance with individuals with stroke to (more) efficiently identify impairments in rapid feedback processing.

Methods

We assessed a cohort of healthy controls (n = 135) and individuals with stroke (n = 40; Mean 41 days from stroke) in the Fast Feedback Interception Task (FFIT) using the Kinarm Exoskeleton robot. Participants were instructed to intercept a circular white target moving towards them with their hand represented as a virtual paddle. On some trials, the arm could be physically perturbed, the target or paddle could abruptly change location, or the target could change colour requiring the individual to now avoid the target.

Results

Most participants with stroke were impaired in reaction time (85%) and end-point accuracy (83%) in at least one of the task conditions, most commonly with target or paddle shifts. Of note, this impairment was also evident in most individuals with stroke when performing the task using their unaffected arm (75%). Comparison with upper limb clinical measures identified moderate correlations with the FFIT.

Conclusion

The FFIT was able to identify a high proportion of individuals with stroke as impaired in rapid feedback processing using either the affected or unaffected arms. The task allows many different types of feedback responses to be efficiently assessed in a short amount of time.
Relay protection mirror operation technology based on digital twin
Authors: Yao Zhiqing , Li Danyang , Li Zhiyong , Zhou Pengpeng , Li Lei
Published: October 2023

When conducting relay protection research, research costs can be significantly reduced if protection principle development, protection parameter verification and debugging can be carried out without relying on actual protection devices. The concept of ‘digital twin’ has made this possible, but the existing research has shortcomings in real-time data interaction ability, protection logic transparency, interface standardization, human–computer interaction etc., and consequently, mirror operation of relay protection in digital space has not been fully realized. Therefore, referring to the characteristics of digital twin, and combining with the practical application requirements in relay protection, this paper proposes the concept and characteristics of relay protection mirror operation based on digital twin. Key solutions are proposed to address the difficulties that may be encountered in the implementation of relay protection mirror operation in terms of protection principles, interfaces, real-time operation of the system, and human–computer interaction function simulation. Finally, an example of 110 kV double-bus and double-branch bus protection is used to verify the feasibility and progressiveness of the scheme proposed in this paper by comparing the action behavior and external characteristics of the twin protection and the actual protection device. The presented research can provide a reference for further in-depth research and application of relay protection using digital means.
Translation, cultural adaptation, and psychometric testing of the Supportive care needs survey for partners and caregivers for Swedish family members of persons diagnosed with colorectal cancer
Authors: Samuelsson Maria , Wennick Anne , Bengtsson Mariette , Lydrup Marie-Louise , Jakobsson Jenny
Published: October 2023

Background

Colorectal cancer is the third most common cancer diagnosis globally and is increasing in both incidence and prevalence. Despite evidence showing that family members of persons diagnosed with cancer have supportive care needs, no validated questionnaire measuring the needs of family members of persons diagnosed with CRC exists in Swedish. Thus, the objective of the present study was to translate, culturally adapt, and evaluate the psychometric properties the Supportive Care Needs Survey – Partners and Caregivers 45.

Methods

The translation and cultural adaptation followed a systematic yet iterative process. Firstly, the questionnaire was translated using a forward–backward approach. Secondly, face and content validity and comprehensibility were evaluated by two expert panels of colorectal cancer specialist nurses and family members, respectively. Lastly, the psychometric properties, validity, and reliability of the translated questionnaire were evaluated among 45 Swedish family members of persons diagnosed with colorectal cancer.

Results

The face, content, and construct validity of the translated questionnaire were evaluated as satisfying. Moreover, psychometric evaluations showed high data quality and satisfactory internal consistency. However, the results also revealed unsolved issues regarding relevance, targeting, and internal consistency, as well as a probable scaling failure.

Conclusion

The translated and adapted questionnaire can be used to identify family members unmet needs of support throughout the colorectal cancer trajectory. The questionnaire showed promising validity and reliability in the target population. However, it needs to be further evaluated in a larger sample, preferably involving factor analysis and stability over time.
Identification and biocontrol potential evaluation of a naturally occurring Metarhizium pingshaense isolate infecting tea weevil Myllocerinus aurolineatus Voss (Coleoptera: Curculionidae)
Authors: Fu Nanxia , Wang Tiekuang , Li Qiurong , Luo Zongxiu , Li Zhaoqun , Bian Lei , Xiu Chunli , Chen Zongmao , Cai Xiaoming
Published: October 2023

Background

Tea weevil, Myllocerinus aurolineatus Voss (Coleoptera: Curculionidae), is an important insect pest in Chinese tea plantations. The primary method for controlling tea weevils involves the use chemical pesticides. Hence, there is an urgent need for environmentally friendly control strategies. To screen for potential pathogenic strains useful for the biocontrol of tea weevils, a naturally occurring Metarhizium pingshaense strain was isolated from a field-collected infected tea weevil larva for the first time in China.

Results

Morphological features and molecular characteristics revealed the isolate was an M. pingshaense strain, herein referred to as Ma0628. At 22 °C (tea weevil pupation temperature), the inoculation with M. pingshaense Ma0628 resulted in a corrected cumulative late instar larval mortality rate exceeding 76% at 11 days after the inoculation with the 1 × 108 conidia/ml spore suspension using the immersion or soil-mixing method. Accordingly, the median lethal concentrations were 4.49 × 103 and 3.76 × 102 conidia/ml for the immersion and soil-mixing inoculation methods, respectively. Furthermore, the corrected cumulative adult mortality rate reached 83.33% at 14 days after the inoculation with the 1 × 108 conidia/ml spore suspension.

Conclusion

The study results indicate that M. pingshaense strain Ma0628 is an entomopathogenic fungus pathogenic to tea weevil larvae and adults, suggesting it may be a potentially useful biocontrol agent for preventing M. aurolineatus infestations.