bluuebunny/crossref_metadata_2025 huggingface dataset:
A Ventilator-associated Pneumonia Prediction Model in Patients With Acute Respiratory Distress Syndrome
Authors: Wu Zongsheng , Liu Yao , Xu Jingyuan , Xie Jianfeng , Zhang Shi , Huang Lili , Huang Yingzi , Yang Yi , Qiu Haibo
Published: November 2020

Background

Mechanical ventilation is crucial for acute respiratory distress syndrome (ARDS) patients and diagnosis of ventilator-associated pneumonia (VAP) in ARDS patients is challenging. Hence, an effective model to predict VAP in ARDS is urgently needed.

Methods

We performed a secondary analysis of patient-level data from the Early versus Delayed Enteral Nutrition (EDEN) of ARDSNet randomized controlled trials. Multivariate binary logistic regression analysis established a predictive model, incorporating characteristics selected by systematic review and univariate analyses. The model’s discrimination, calibration, and clinical usefulness were assessed using the C-index, calibration plot, and decision curve analysis (DCA).

Results

Of the 1000 unique patients enrolled in the EDEN trials, 70 (7%) had ARDS complicated with VAP. Mechanical ventilation duration and intensive care unit (ICU) stay were significantly longer in the VAP group than non-VAP group (P < .001 for both) but the 60-day mortality was comparable. Use of neuromuscular blocking agents, severe ARDS, admission for unscheduled surgery, and trauma as primary ARDS causes were independent risk factors for VAP. The area under the curve of the model was .744, and model fit was acceptable (Hosmer-Lemeshow P = .185). The calibration curve indicated that the model had proper discrimination and good calibration. DCA showed that the VAP prediction nomogram was clinically useful when an intervention was decided at a VAP probability threshold between 1% and 61%.

Conclusions

The prediction nomogram for VAP development in ARDS patients can be applied after ICU admission, using available variables. Potential clinical benefits of using this model deserve further assessment.
Epidemiological Impact and Cost-Effectiveness of Varicella Vaccination Strategies in the United Kingdom
Authors: Akpo Esse Ifebi Herve , Cristeau Olivier , Hunjan Manjit , Casabona Giacomo
Published: November 2020

Background

Despite the burden of varicella, there is no universal varicella vaccination (UVV) program in the United Kingdom (UK) due to concerns that it could increase herpes zoster (HZ) incidence. We assessed the cost-utility of a first-dose monovalent (varicella [V]) or quadrivalent (measles-mumps-rubella-varicella [MMRV]) followed by a second-dose MMRV UVV program. GSK and MSD varicella-containing vaccines (VCVs) were considered.

Methods

Dynamic transmission and cost-effectiveness models were adapted to the UK. Outcomes measured included varicella and HZ incidences and the incremental cost-utility ratio (ICURs) over a lifetime horizon. Payer and societal perspectives were evaluated.

Results

The impact of V-MMRV and MMRV-MMRV UVV programs on varicella incidence was comparable between both VCVs at equilibrium. HZ incidence increased by 1.6%–1.7% over 7 years after UVV start, regardless of the strategies, then decreased by >95% at equilibrium. ICURs ranged from £5665 (100 years) to £18 513 (20 years) per quality-adjusted life-year (QALY) gained with V-MMRV and from £9220 to £27 101 per QALY gained with MMRV-MMRV (payer perspective). MMRV-MMRV was cost-effective in the medium- and long-terms with GSK VCV and only cost-effective in the long term with MSD VCV at a £20 000 per QALY gained threshold. Without the exogenous boosting hypothesis, HZ incidence decreased through UVV implementation. ICURs were most sensitive to discount rates and MMRV price.

Conclusions

A 2-dose UVV was demonstrated to be a cost-effective alternative to no vaccination. With comparable effectiveness as MSD VCV at lower costs, GSK VCV may offer higher value for the money.
Trends in Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia Trials
Authors: Bart Stephen M , Rubin Daniel , Kim Peter , Farley John J , Nambiar Sumathi
Published: November 2020

Background

New drug development for hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP) is critical. Challenges remain in the conduct of HABP/VABP trials, especially in the contexts of enrollment, endpoints, nonstudy antibacterial drug therapy, and antimicrobial resistance.

Methods

Four Phase 3 noninferiority trials (n = 2433 participants) submitted to the Food and Drug Administration after 2015 were analyzed for enrollment statistics, participant characteristics associated with 28-day all-cause mortality (ACM), microbiology, and receipt of nonstudy antibacterial drugs. All trials primarily enrolled patients with gram-negative bacterial infections.

Results

The mean trial length was 2.7 years and the mean recruitment rate was 0.17 participants/site/month. ACM at 28 days was 17.1% and was higher among participants diagnosed with ventilated HABP (31.9%) or VABP (19.0%) than nonventilated HABP (9.9%). VABP participants tended to be younger, less likely to have chronic obstructive pulmonary disease, and more likely to have previously sustained an injury. Age, South American residence, diagnosis of ventilated HABP or VABP, and Acinetobacter baumannii infection were all associated with 28-day ACM in a multivariate logistic regression model. Infection by A. baumannii was most common in Eastern European and Asia/Pacific participants, and Eastern European isolates exhibited the highest levels of meropenem resistance. Concomitant nonstudy antibacterial drug therapy most commonly included beta-lactams and was initiated earliest in Western Europe.

Conclusion

This analysis of recent trials may assist in trial considerations for HABP/VABP development programs and promote needed antibacterial drug development for patients with serious infections.
Inflammation in Atherosclerosis—No Longer a Theory
Authors: Libby Peter
Published: November 2020

Background

Inflammation links to atherosclerosis and its complications in various experimental investigations. Animal studies have implicated numerous inflammatory mediators in the initiation and complication of atherosclerosis. Numerous studies in humans have shown associations of biomarkers of inflammation with cardiovascular events provoked by atheromata. Inflammatory status, determined by the biomarker C-reactive protein, can guide the allocation of statin therapy to individuals without elevated low-density lipoprotein (LDL) concentrations to prevent first ever adverse cardiovascular events.

Content

Until recently, no direct evidence has shown that an intervention that selectively limits inflammation can improve outcomes in patients with atherosclerosis. A recent study, based on decades of preclinical investigation, treated patients who had sustained a myocardial infarction and whose LDL was well-controlled on statin treatment with an antibody that neutralizes interleukin-1 beta. This trial, conducted in over 10 000 individuals, showed a reduction in major adverse cardiac events, establishing for the first time the clinical efficacy of an anti-inflammatory intervention in atherosclerosis. Two large subsequent studies have shown that colchicine treatment can also prevent recurrent events in patients recovering from an acute coronary syndrome or in the stable phase of coronary artery disease. These clinical trials have transformed inflammation in atherosclerosis from theory to practice.

Much work remains to optimize further anti-inflammatory interventions, minimize unwanted actions, and refine patient selection. This long road from discovery in the laboratory to successful clinical trials represents a victory for medical science, and opens a new avenue to reducing the risk that remains despite current treatments for atherosclerosis.
Diverging landscape impacts on macronutrient status despite overlapping diets in managed (Apis mellifera) and native (Melissodes desponsa) bees
Authors: Mogren Christina L , Benítez María-Soledad , McCarter Kevin , Boyer Frédéric , Lundgren Jonathan G
Published: November 2020

Declining pollinator populations worldwide are attributed to multiple stressors, including the loss of quality forage. Habitat management in agricultural areas often targets honey bees (Apis mellifera L.) specifically, with the assumption that native bees will benefit from an ‘umbrella species’ strategy. We tested this theory using a conservation physiology approach to compare the effects of landscape composition and floral dietary composition on the physiological status of honey bees and Melissodes desponsa in eastern South Dakota, USA. The total glycogen, lipid and protein concentrations were quantified from field collected bees. Next-generation sequencing of the trnL chloroplast gene from bee guts was used to evaluate dietary composition. The effects of landscape and dietary composition on macronutrient concentrations were compared between bee species. As the mean land-use patch area increased, honey bee glycogen levels increased, though M. desponsa experienced a decrease in glycogen. Protein levels decreased in honey bees as the largest patch index, a measure of single patch dominance, increased versus M. desponsa. Lipids in both species were unaffected by the measured landscape variables. Dietary analysis revealed that honey bees foraged preferentially on weedy non-native plant species, while M. desponsa sought out native and rarer species, in addition to utilizing non-native plants. Both species foraged on Asteraceae, Oleaceae and Fabaceae, specifically Melilotus sp. and Medicago sp. Dietary composition was not predictive of the macronutrients measured for either species. Together, these data highlight the management importance of including patch area in conservation recommendations, as bee species may have divergent physiological responses to landscape characteristics. While solitary bees may forage on weedy introduced plants in agricultural areas, robust strategies should also reincorporate native plant species, though they may not be preferred by honey bees, to maximize overall health and diversity of pollinator communities.
Respice, Adspice, Prospice: The ‘Marathon Stone’, Lewisohn Stadium, and the changing reception of the classics at City College in the twentieth century
Authors: Macaulay-Lewis Elizabeth , Reilly Matthew C
Published: November 2020

Throughout its history, New York has received several archaeological objects as gifts, including a mid-fourth-century BCE Greek funerary stele. Dr John Huston Finley, the third president of City College, saw a stele when he was in Greece and asked the Greek Government to gift the stele to the college. The stele, dubbed the ‘Marathon Stone’ by Finley, was dedicated and proudly displayed at City College, now of the City University of New York. This article explores the gift’s context by drawing on contemporary newspaper reports, Finley’s tenuous association of the stele with the battle of Marathon, and the gifting of an archaeological object as a means for promoting ties between City College and Greece. The article then examines the context for the stele’s display, the Neo-Antique Lewisohn Stadium, and argues that the display of the stele and erection of Lewisohn Stadium both embodied Finley’s aspirations for City College to rival Columbia and New York Universities. The demise of the stadium in 1973 and the removal of the stele to a basement signaled a major shift in the significance of the classics, classical art, and Neo-Antique architecture at City College, as well as the changing priorities of the institution.
Effect of empagliflozin on exercise ability and symptoms in heart failure patients with reduced and preserved ejection fraction, with and without type 2 diabetes
Authors: Abraham William T , Lindenfeld JoAnn , Ponikowski Piotr , Agostoni Piergiuseppe , Butler Javed , Desai Akshay S , Filippatos Gerasimos , Gniot Jacek , Fu Michael , Gullestad Lars , Howlett Jonathan G , Nicholls Stephen J , Redon Josep , Schenkenberger Isabelle , Silva-Cardoso José , Störk Stefan , Krzysztof Wranicz Jerzy , Savarese Gianluigi , Brueckmann Martina , Jamal Waheed , Nordaby Matias , Peil Barbara , Ritter Ivana , Ustyugova Anastasia , Zeller Cordula , Salsali Afshin , Anker Stefan D
Published: November 2020

Aims

The EMPERIAL (Effect of EMPagliflozin on ExeRcise ability and HF symptoms In patients with chronic heArt faiLure) trials evaluated the effects of empagliflozin on exercise ability and patient-reported outcomes in heart failure (HF) with reduced and preserved ejection fraction (EF), with and without type 2 diabetes (T2D), reporting, for the first time, the effects of sodium-glucose co-transporter-2 inhibition in HF with preserved EF (HFpEF).

Methods and results

HF patients with reduced EF (HFrEF) (≤40%, N = 312, EMPERIAL-Reduced) or preserved EF (>40%, N = 315, EMPERIAL-Preserved), with and without T2D, were randomized to empagliflozin 10 mg or placebo for 12 weeks. The primary endpoint was 6-minute walk test distance (6MWTD) change to Week 12. Key secondary endpoints included Kansas City Cardiomyopathy Questionnaire Total Symptom Score (KCCQ-TSS) and Chronic Heart Failure Questionnaire Self-Administered Standardized format (CHQ-SAS) dyspnoea score. 6MWTD median (95% confidence interval) differences, empagliflozin vs. placebo, at Week 12 were −4.0 m (−16.0, 6.0; P = 0.42) and 4.0 m (−5.0, 13.0; P = 0.37) in EMPERIAL-Reduced and EMPERIAL-Preserved, respectively. As the primary endpoint was non-significant, all secondary endpoints were considered exploratory. Changes in KCCQ-TSS and CHQ-SAS dyspnoea score were non-significant. Improvements with empagliflozin in exploratory pre-specified analyses of KCCQ-TSS responder rates, congestion score, and diuretic use in EMPERIAL-Reduced are hypothesis generating. Empagliflozin adverse events were consistent with those previously reported.

Conclusion

The primary outcome for both trials was neutral. Empagliflozin was well tolerated in HF patients, with and without T2D, with a safety profile consistent with that previously reported in T2D. Hypothesis-generating improvements in exploratory analyses of secondary endpoints with empagliflozin in HFrEF were observed.
Quantifying the Predictive Performance of Objectively Measured Physical Activity on Mortality in the UK Biobank
Authors: Leroux Andrew , Xu Shiyao , Kundu Prosenjit , Muschelli John , Smirnova Ekaterina , Chatterjee Nilanjan , Crainiceanu Ciprian
Published: November 2020

Background

Objective measures of physical activity (PA) derived from wrist-worn accelerometers are compared with traditional risk factors in terms of mortality prediction performance in the UK Biobank.

Method

A subset of participants in the UK Biobank study wore a tri-axial wrist-worn accelerometer in a free-living environment for up to 7 days. A total of 82 304 individuals over the age of 50 (439 707 person-years of follow-up, 1959 deaths) had both accelerometry data that met specified quality criteria and complete data on a set of traditional mortality risk factors. Predictive performance was assessed using cross-validated Concordance (C) for Cox regression models. Forward selection was used to obtain a set of best predictors of mortality.

Results

In univariate Cox regression, age was the best predictor of all-cause mortality (C = 0.681) followed by 12 PA predictors, led by minutes of moderate-to-vigorous PA (C = 0.661) and total acceleration (C = 0.661). Overall, 16 of the top 20 predictors were objective PA measures (C = 0.578–0.661). Using a threshold of 0.001 improvement in Concordance, the Concordance for the best model that did not include PA measures was 0.735 (9 covariates) compared with 0.748 (12 covariates) for the best model with PA variables (p-value < .001).

Conclusions

Objective measures of PA derived from accelerometry outperform traditional predictors of all-cause mortality in the UK Biobank except age and substantially improve the prediction performance of mortality models based on traditional risk factors. Results confirm and complement previous findings in the National Health and Nutrition Examination Survey (NHANES).
Physical Activity in Early- and Mid-Adulthood Are Independently Associated With Longitudinal Memory Trajectories in Later Life
Authors: Kraal A Zarina , Dotterer Hailey L , Sharifian Neika , Morris Emily P , Sol Ketlyne , Zaheed Afara B , Smith Jacqui , Zahodne Laura B
Published: November 2020

Background

Physical activity (PA) in later life may reduce dementia risk, but little is known regarding long-term cognitive effects of PA that occurred earlier in adulthood or mechanisms underlying associations. PA patterns at different ages may independently contribute to dementia risk, which would implicate multiple critical periods for intervention. The current study tested whether retrospective reports of PA in early and mid-adulthood were independently associated with later-life longitudinal memory outcomes and whether associations were mediated by late-life cardiometabolic diseases.

Method

Participants comprised 5200 Health and Retirement Study Life History Mail Survey respondents. Latent growth curves estimated independent associations between retrospectively reported PA in early adulthood (age 18–29) and mid-adulthood (age 40–49) and 16-year episodic memory trajectories. Indirect pathways involving the maintenance of PA from early- to mid-adulthood and the influence of PA on later-life cardiometabolic diseases (hypertension, diabetes, and heart disease) were also estimated.

Results

PA in early- and mid-adulthood independently predicted higher initial memory level and slower memory decline in later life, respectively. Early-adulthood PA was indirectly associated with later-life memory level through higher mid-adulthood PA and lower rates of later-life hypertension, as well as with subsequent memory decline through higher mid-adulthood PA.

Conclusions

The current findings highlight the importance of PA throughout adulthood, such that initiating and/or maintaining exercise in early- or mid-adulthood may be protective for later-life cognitive health, and hypertension appears to represent a key mediator of these effects.
PSHA of the southern Pacific Islands
Authors: Johnson K L , Pagani M , Styron R H
Published: November 2020

The southern Pacific Islands region is highly seismically active, and includes earthquakes from four major subduction systems, seafloor fracture zones and transform faults, and other sources of crustal seismicity. Since 1900, the area has experienced >350 earthquakes of M > 7.0, including 11 of M ≥ 8.0. Given the elevated threat of earthquakes, several probabilistic seismic hazard analyses have been published for this region or encompassed subregions; however, those that are publicly accessible do not provide complete coverage of the region using homogeneous methodologies. Here, we present a probabilistic seismic hazard model for the southern Pacific Islands that comprehensively covers the Solomon Islands in the northwest to the Tonga islands in the southeast. The seismic source model accounts for active shallow crustal seismicity with seafloor faults and gridded smoothed seismicity, subduction interfaces using faults with geometries defined based on geophysical datasets and models, and intraslab seismicity modelled by a set of ruptures that occupy the slab volume. Each source type is assigned occurrence rates based on sub-catalogues classified to each respective tectonic context. Subduction interface and crustal fault occurrence rates also incorporate a tectonic component based on their respective characteristic earthquakes. We demonstrate the use of non-standard magnitude-frequency distributions to reproduce the observed occurrence rates. For subduction interface sources, we use various versions of the source model to account for epistemic uncertainty in factors impacting the maximum magnitude earthquake permissible by each source, varying the interface lower depth and segmentation as well as the magnitude scaling relationship used to compute the maximum magnitude earthquake and subsequently its occurrence rate. The ground motion characterisation uses a logic tree that weights three ground motion prediction equations for each tectonic region. We compute hazard maps for 10% and 2% probability of exceedance in 50 years on rock sites, discussing the regional distribution of peak ground acceleration and spectral acceleration with a period of 1.0 s, honing in on the hazard curves and uniform hazard spectra of several capital or populous cities and drawing comparisons to other recent hazard models. The results reveal that the most hazardous landmasses are the island chains closest to subduction trenches, as well as localised areas with high rates of seismicity occurring in active shallow crust. We use seismic hazard disaggregation to demonstrate that at selected cities located above subduction zones, the PGA with 10% probability of exceedance in 50 years is controlled by Mw > 7.0 subduction interface and intraslab earthquakes, while at cities far from subduction zones, Mw < 6.5 crustal earthquakes contribute most. The model is used for southern Pacific Islands coverage in the Global Earthquake Model Global Hazard Mosaic.
Transdimensional Markov Chain Monte Carlo joint inversion of direct current resistivity and transient electromagnetic data
Authors: Peng Ronghua , Yogeshwar Pritam , Liu Yajun , Hu Xiangyun
Published: November 2020

Joint inversion of multiple geophysical data sets with complementary information content can significantly reduce the non-uniqueness inherent to each individual data set and, therefore, can improve subsurface characterization. Gradient-based joint inversion methods depend on the choice of model regularization and usually produce one single optimal model, and rely on linearization to estimate model parameter uncertainty. However, a quantitative evaluation of the parameter uncertainty of the derived model parameters is crucial for reliable data interpretation. In this study, we present a transdimensional Markov Chain Monte Carlo (MCMC) method for the joint inversion of direct current resistivity and transient electromagnetic data, which provides a rigorous assessment of the uncertainty associated with the derived model. The transdimensional property of the algorithm allows the number of unknown model parameters to be determined adaptively by the data. This usually favours models with fewer parameters through the parsimony criterion of the Bayesian method by choosing suitable prior distributions. In this paper, we demonstrate that the transdimensional MCMC method combines complementary information contained in each data set and reduces the overall uncertainty using synthetic examples. Furthermore, we successfully applied the new joint inversion scheme to field data from Azraq, Jordan. The transdimensional MCMC inversion results are in good agreement with the results obtained by deterministic inversion techniques. From the MCMC inversion results we identified the thickness of a basalt formation and a conductive zone, which were uncertain and not interpreted in prior studies, adding to the geological interpretation.
Conceptualizing the role of courts in peace processes
Authors: Tushnet Mark , Arcila Beatriz Botero
Published: November 2020

What role do courts play in peace processes? Relying on case studies of South Africa and Colombia, we identify two functions. First, by invalidating some peripheral provisions constitutional courts can enhance the legitimacy of those agreements by adding the imprimatur of legalism to the political support the agreements already have. Second, the international law of impunity can be an obstacle to reaching a peace agreement, but domestic courts can weaken that impediment by deferring a confrontation with that law by creative interpretation of both the peace agreement and international law, thereby postponing to the indefinite future any actual confrontation between the agreement and international law.
(Un)constitutional change rooted in peace agreements
Authors: Ozcelik Asli , Olcay Tarik
Published: November 2020

Peace agreements aiming to end intra-state armed conflicts often provide for radical constitutional change, with more than 100 peace agreements concluded since 1989 containing provisions on constitutional reform. When such constitutional change is envisaged to take place within the framework of an existing constitution, as opposed to the making of a new constitution, hard-achieved deals between peace-making parties are exposed to “the unconstitutionality challenge.” Although there is ample literature on the making of a new constitution during transitions from conflict to peace, implementing a peace agreement within an existing constitutional framework and “the unconstitutionality challenge” to peace reforms has not been fully examined to date. In this article, we first identify the modalities in which “the unconstitutionality challenge” is directed at constitutional change rooted in peace agreements. We do so through a comparative survey and by particular reference to peace processes in Colombia (with the Revolutionary Armed Forces of Colombia—People’s Army, FARC) and the Philippines (regarding the Mindanao conflict). We then examine the promise and limitations of three legal strategies in addressing the unconstitutionality challenge: (i) recourse to international law in assessing unconstitutionality, (ii) transitionalism in judicial review, and (iii) attributing supra-constitutional or international legal status to peace agreements. We conclude that while each strategy has some merit, their effectiveness may be limited where they lack legal feasibility or political purchase. The resulting intractability of the unconstitutionality challenge, particularly in jurisdictions where there is a strong commitment to legalism, warrants a rethinking of the relationship between peace-making and constitutional reform, and existing constitutional frameworks in transitional countries.
Economic growth, openness, industry and CO2 modelling: are regulatory policies important in Turkish economies?
Authors: Kılavuz Emine , Doğan İbrahim
Published: November 2020

As a result of economic growth, demand for energy increases as well as raw materials. The fact that energy sources are mostly fossil fuels has increased interest in causation between growth and environmental pollution. As global warming and climate changes gain importance in recent years, environmental pollution continues to be discussed in the economic literature. As Turkey’s economy grows rapidly, its increasing energy needs are often met with fossil fuels because they are cheaper than other options. This study analyzes the availability of the environmental Kuznets curve (EKC) hypothesis, which analyzes an inverse U-shaped relation among carbon dioxide (CO2) emissions per capita and output for Turkey in the period 1961–2018. The study used the autoregressive distributed lag to demonstrate the short- and long-term relationship between CO2 emissions per capita, real income per capita, industry and trade openness. The conclusions do confirm that there is a quadratic relation between income and CO2 emissions, supporting EKC relation in the long term. The results also demonstrate that the CO2, which is a major component of greenhouse gases, are mainly specified by income in the long term and short term. The contribution of industry to CO2 is minimal in the long run, while trade openness does not have any effect.
Metabolic Flexibility in Response to Within-Season Temperature Variability in House Sparrows
Authors: Swanson D L , Agin T J , Zhang Y , Oboikovitz P , DuBay S
Published: November 2020

Synopsis

The climatic variability hypothesis (CVH) posits that more flexible phenotypes should provide a fitness advantage for organisms experiencing more variable climates. While typically applied across geographically separated populations, whether this principle applies across seasons or other conditions (e.g., open vs. sheltered habitats) which differ in climatic variability remains essentially unstudied. In north-temperate climates, climatic variability in winter usually exceeds that in summer, so extending the CVH to within-population seasonal variation predicts that winter phenotypes should be more flexible than summer phenotypes. We tested this prediction of the within-season extension of the CVH by acclimating summer and winter-collected house sparrows (Passer domesticus) to 24, 5, and −10°C and measuring basal metabolic rate (BMR) and summit metabolic rate (Msum = maximum cold-induced metabolic rate) before and after acclimation (Accl). To examine mechanistic bases for metabolic variation, we measured flight muscle and heart masses and citrate synthase and β-hydroxyacyl coA-dehydrogenase activities. BMR and Msum were higher for cold-acclimated than for warm-acclimated birds, and BMR was higher in winter than in summer birds. Contrary to our hypothesis of greater responses to cold Accl in winter birds, metabolic rates generally decreased over the Accl period for winter birds at all temperatures but increased at cold temperatures for summer birds. Flight muscle and heart masses were not significantly correlated with season or Accl treatment, except for supracoracoideus mass, which was lower at −10°C in winter, but flight muscle and heart masses were positively correlated with BMR and flight muscle mass was positively correlated with Msum. Catabolic enzyme activities were not clearly related to metabolic variation. Thus, our data suggest that predictions of the CVH may not be relevant when extended to seasonal temperature variability at the within-population scale. Indeed, these data suggest that metabolic rates are more prominently upregulated in summer than in winter in response to cold. Metabolic rates tended to decrease during Accl at all temperatures in winter, suggesting that initial metabolic rates at capture (higher in winter) influence metabolic Accl for captive birds.
Reproduction and reproductive tract morphology of male and female pigs whose mothers were heat stressed during the second month of gestation
Authors: Bernhard Cathy J , Sharp Katharine G , Safranski Timothy J , Lamberson William R , Lucy Matthew C
Published: November 2020

The primary objective was to assess the development of fetal gonads and measure the subsequent reproductive capacity of boars and gilts whose mother was either subjected to gestational heat stress (GHS) or thermoneutral (GTN; control) conditions during pregnancy. Gilts were subjected to either GHS (28 to 38 °C; 65% to 88% relative humidity [RH]; n = 30) or GTN (17 to 22 °C; 56% to 65% RH; n = 29) for the second month of gestation (a period that coincides with a critical window of gonadal development). A subset of GHS (n = 12) and GTN (n = 11) gilts was sacrificed immediately following treatment for the collection of pregnancy data. The remaining gilts (n = 18 GHS and n = 18 GTN) were allowed to farrow. Female offspring from the farrowed gilts were studied through puberty, first insemination, and early pregnancy when fetal tissues were again collected. During the treatment period, GHS gilts had greater (P < 0.001) rectal temperature and respiration rate at both measurement time points (morning and afternoon) compared with GTN gilts. When assessed at the end of the second month of gestation, the total number of viable fetuses did not differ (P > 0.10) for GHS vs. GTN. Likewise, the weight of the fetus, placenta, fetal testes, and fetal ovaries were similar (P > 0.10) for GHS and GTN pregnancies. There was a tendency for an effect of treatment (63.3 ± 2.3 vs. 70.1 ± 2.6; GHS vs. GTN; P < 0.073) on the number of oogonia per histological section in the fetal ovaries. There was no effect of treatment on the number of prespermatogonia per histological section in the fetal testis. For gilts farrowing after treatment, litter size, piglet birth weight, and weaning weight were similar (P > 0.10) for the GHS and GTN gilts. Testes collected from castrated GHS boars had fewer prespermatogonia per seminiferous tubule cross section (P < 0.049). Female offspring from the GHS (n = 30) or GTN (n = 37) sows reached puberty at a similar age, and their pregnancies (ninth week of gestation) had fewer corpora lutea (15.6 ± 0.5 vs. 17.1 ± 0.4; GHS vs. GTN; P < 0.038) but the number of fetuses was similar for GHS and GTN. In summary, compared with GTN, GHS during a critical window of gonadal development tended to reduce the number of oogonia in the fetal ovary, reduced the number of prespermatogonia in the neonatal testes, and reduced ovulation rate at first pregnancy in gilts.
Multilateralizing Investment Facilitation at the WTO: Looking for the Added Value
Authors: Calamita N Jansen
Published: November 2020

Since 2017, World Trade Organization members have been engaged in Structured Discussions aimed at agreeing on a multilateral framework on investment facilitation for development. The negotiations focus on establishing binding disciplines for investment facilitation, which will likely be made subject to the World Trade Organization Dispute Settlement Understanding. Investment facilitation, however, is that something states already do. Over the past decade, states have adopted record numbers of reforms at the domestic, regional, and international levels to facilitate foreign investment. These reforms show no signs of slowing. This begs an important question regarding the World Trade Organization initiative: given all the attention that investment facilitation already receives from states and international organizations, how, if at all, would the conclusion of a World Trade Organization Framework bring added value to states, i.e. value that cannot be achieved by ongoing efforts? Examining this question is the focus of this paper.
Resolving Conflict in Real Time: Operationalizing Culture Transformation in Deployments
Authors: Weber Eric D
Published: November 2020

Preparation is the key to performance. The Army invests substantially in team and unit preparation prior to deployments. However, despite the time and training to build camaraderie and confidence in one another, conflict still arises within units. Most training does not address the underlying mindset that is the source of conflict. Army medicine has utilized training material that addresses the mindset source of conflict to improve team and organizational collaboration and outcomes in hospital settings. We adapted this current Army training to conditions in a deployment environment and improved the culture and reduced the conflict in the unit.
AAIT: A novel prognostic model for HIV-negative patients with cryptococcal meningoencephalitis New Scoring Model for Non-HIV Patients with CM
Authors: Cai Qun , Wang Hao , Ruan Sihan , Zhu Mingyan , Duan Jinnan , Sun Shanshan , Sheng Jifang
Published: November 2020

Cryptococcal meningitis (CM) is a common opportunistic infection in HIV-negative patients, with mortality rates as high as those in the HIV-negative population. This requires accurate initial clinical decision-making, warranting the development of a prognostic score. Two groups of patients were investigated separately to develop a novel prognostic model (AAIT) for HIV-negative patients with CM. A retrospective analysis of 201 HIV-negative patients with CM was conducted to develop the CM prognostic score. In addition, the CM cohort (n = 21) was recruited longitudinally to verify the new prognostic score. Meanwhile, the association between the prognostic score and 1-year mortality of CM was expounded. AAIT (age, albumin, combined bacterial infection, and total triiodothyronine) is a novel prognostic score based on age, albumin level, combined bacterial infection, and total triiodothyronine (TT3) level, which were significantly higher in nonsurvivors than in survivors (0.68 [−0.70 to 1.55] vs − 1.72 [−3.75 to −0.73], P < .00). Regarding the AAIT-predicted 1-year mortality, the area under the receiver operating characteristic curve (AUROC) value was 0.857, whereas it was 0.965 for the validation cohort. In the induction period, different treatment options did not seem to significantly improve the 1-year survival rate. AAIT is a straightforward and clear prognostic score that can add value to predict the outcomes in HIV-negative patients with CM. In addition, controlling infection and increasing the albumin and TT3 levels may help improve clinical outcomes in HIV-negative patients with CM.
Quasi-equilibrium models of high-redshift disc galaxy evolution
Authors: Furlanetto Steven R
Published: November 2020

In recent years, simple models of galaxy formation have been shown to provide reasonably good matches to available data on high-redshift luminosity functions. However, these prescriptions are primarily phenomenological, with only crude connections to the physics of galaxy evolution. Here, we introduce a set of galaxy models that are based on a simple physical framework but incorporate more sophisticated models of feedback, star formation, and other processes. We apply these models to the high-redshift regime, showing that most of the generic predictions of the simplest models remain valid. In particular, the stellar mass–halo mass relation depends almost entirely on the physics of feedback (and is thus independent of the details of small-scale star formation) and the specific star formation rate is a simple multiple of the cosmological accretion rate. We also show that, in contrast, the galaxy’s gas mass is sensitive to the physics of star formation, although the inclusion of feedback-driven star formation laws significantly changes the naive expectations. While these models are far from detailed enough to describe every aspect of galaxy formation, they inform our understanding of galaxy formation by illustrating several generic aspects of that process, and they provide a physically grounded basis for extrapolating predictions to faint galaxies and high redshifts currently out of reach of observations. If observations show violations from these simple trends, they would indicate new physics occurring inside the earliest generations of galaxies.
Engagement among physicians fighting COVID-19: the mediating role of autonomy
Authors: Zhang H , Zhao Y , Zou P , Liu Y , Gan L
Published: November 2020

Background

Keeping and improving work engagement among physicians fighting COVID-19 is important to healthy medical systems. In line with the job demands-resources model, optimism was expected to positively relate with job resources, leading to higher work engagement. However, the underlying mechanism between optimism, autonomy and work engagement has not been explored.

Aims

To examine whether optimism has a positive impact on work engagement via autonomy among physicians fighting COVID-19 in China.

Methods

This study was conducted among physicians in March 2020. A convenience sample was used to recruit physicians from the Wuhan Leishenshan Hospital and Wuhan Jinyintan Hospital. One hundred and four Chinese physicians working in the COVID-19 epidemic completed a survey measuring levels of autonomy, optimism and work engagement. The PROCESS macro (model 4) was used to test hypotheses about mediation.

Results

This current study found that optimism was related to increased autonomy, and autonomy was related to increased work engagement. The results of the bias-corrected bootstrap method suggested the indirect effect of optimism on work engagement via autonomy (Effect = 0.16, SE = 0.08, lower level confidence interval = 0.04, upper level confidence interval = 0.37), indicating a mediated relationship, in which autonomy is one mechanism to explain the link between optimism and increased work engagement.

Conclusions

This study follows an observational design, with in-depth analysis of the relationship between optimism, autonomy and work engagement. When management implements strategies to improve work engagement among physicians working in the COVID-19 epidemic, the mediating impact of autonomy on the association between optimism and work engagement should be considered.
Introduction to and spread of COVID-19-like illness in care homes in Norfolk, UK
Authors: Brainard Julii , Rushton Steven , Winters Tim , Hunter Paul R
Published: November 2020

Background

Residential care homes for the elderly are important settings for transmission of the SARS-CoV-2 virus that causes COVID-19 disease.

Methods

We undertook secondary analysis of 248 care homes in Norfolk, UK. The dataset counted nurses, care workers and non-care workers, their status (available, absent due to leave or sickness and extra staff needed to address the coronavirus pandemic) and residents (if any) with suspected COVID-19 in the period 6 April to 6 May 2020. Concurrent descriptions of access by the home to personal protection equipment (PPE: gloves, masks, eye protection, aprons and sanitizer) were in the data. PPE access was categorized as (most to least) green, amber or red. We undertook two-stage modelling, first for suspected COVID-19 cases amongst residents and second relating any increases in case counts after introduction to staffing or PPE levels.

Results

Counts of non-care workers had strongest relationships (P < 0.05) to introduction of suspected SARS-CoV-2 to the homes. Higher staff levels and more severe PPE shortages were linked to higher case counts (P < 0.05) during the monitoring period.

Conclusion

Managing aspects of staff interaction with residents and some working practices might reduce ingression to and spread of COVID-19-like illness within care homes.
Detection of Type I and III collagen in porcine acellular matrix using HPLC–MS
Authors: Zhang Yang , Chen Yi , Zhao Bo , Gao Jianping , Xia Leilei , Xing Fangyu , Kong Yingjun , Li Yongchao , Zhang Guifeng
Published: November 2020

Acellular matrix (ACM) has been widely used as a biomaterial. As the main component of ACM, collagen type and content show influence on the material properties. In this research, the collagen in ACM from different tissues of pig were determined by detection of marker peptides. The marker peptides of Type I and III collagen were identified from the digested collagen standards using ions trap mass spectrometry (LCQ). The relationship between the abundance of marker peptide and collagen concentration was established using triple quadrupole mass spectrometer (TSQ). The contents of Type I and III collagen in ACM from different tissues were determined. The method was further verified by hydroxyproline determination. The results showed that, the sum of Type I and III collagen contents in the ACM from small intestinal submucosa, dermis and Achilles tendon of pig were about 87.59, 81.41 and 61.13%, respectively, which were close to the total collagen contents in these tissues. The results proved that this method could quantitatively detect the collagen with different types in the ACM of various tissues.
Relationship between live body condition score and carcass fat measures in equine
Authors: Baker Lance A , Burrows Amanda M , Nonella Kelsey J , Pipkin John L , Holmes Logan D , McEvers Trent J , Tennant Travis C , Tisdale Zane M , Voyles Austin H , Lawrence Ty E
Published: November 2020

Relationships between live body condition score (BCS) and carcass fat depots have not been well established in equine. Our study was designed to quantify the relationship between BCS and fat depot measurements from equine carcasses. Live horses (n = 429) were evaluated immediately prior to immobilization at a commercial equine processor. Horses were independently assigned a BCS by a panel of three trained evaluators; BCS was evaluated by visual appraisal and manual palpation of the neck, withers, back, ribs, behind the shoulder, and tailhead. Median BCS frequencies were: 3.0 (n = 9), 4.0 (n = 43), 5.0 (n = 116), 6.0 (n = 86), 7.0 (n = 72), 8.0 (n = 76), and 9.0 (n = 27). Sex (stallion [n = 5], mare [n = 159], or gelding [n = 114]) and breed type (draft [n = 56], stock [n = 363], pony [n = 8], or mule [n =3]) were also denoted. Horses were processed for human consumption according to industry-accepted procedures under the supervision of the Canadian Food Inspection Agency. During the harvest process, all kidney–pelvic–heart (KPH) fat was trimmed from the carcass and weighed. After chilling, the marbling score was subjectively evaluated using beef grading standards. Carcass fat trim was weighed during the fabrication process. As BCS increased, hot carcass weight (HCW), absolute KPH weight, KPH expressed as a percentage of HCW, marbling score, neck fat depth, absolute weight of trimmed carcass fat, and trimmed carcass fat as a percentage of HCW increased (P < 0.01). A strong correlation (r = 0.74; P < 0.01) was detected between BCS and absolute KPH weight. Similarly, correlations between BCS and percentage of KPH (r = 0.65), neck fat depth (r = 0.60), absolute trimmed carcass fat (r = 0.58), trimmed carcass fat as a percentage of HCW (r = 0.54), marbling score (r = 0.54), and HCW (r = 0.52) were also detected (P < 0.01). These data indicate a strong relationship between subjective live BCS and objectively measured carcass fat depots in various equine breed types and sexes.
A system and analytical method for testing the electrical parameters of soil
Authors: Han Yue , Che Ailan , Feng Shaokong
Published: November 2020

The electrical parameters of the rock and soil are closely related to the physical parameters. By measuring the resistivity and polarizability of rock and soil reasonably, information on physical parameters such as moisture content, pore ratio and compaction degree can be obtained. A system for testing the electrical parameters of soil samples based on the middle step quadrupole method is developed in this article. The system uses a series of copper needles as the electrodes of the soil-mounted test tube, and uses a multi-point multi-layer test method for layered data acquisition, which can solve the problems caused by the capacitance phenomenon and the heterogeneity of the soil sample. At the same time, factors affecting the test results, such as uneven soil preparation and water addition and electrode disturbance, are regarded as noise. A data-analysis method based on median filtering is proposed to process and analyse the test results, and the relationships between resistivity, polarizability, moisture content and compaction degree of the sample are obtained. The results show that the resistivity decreases nonlinearly as moisture content increases, and the correlation with compaction is not strong; the polarizability increases as moisture content increases with fluctuation, and it first increases and then decreases with an increase in compaction.