bluuebunny/crossref_metadata_2025 huggingface dataset:
Benign phyllodes tumour in a transgender woman receiving hormonal therapy
Authors: Dillon Jacquelyn , Bernik Stephanie , Zeizafoun Nebras , Balija Tara
Published: March 2024

We present a case of a transwoman taking hormonal feminisation therapy for over 20 years, who underwent surgical excision of a benign phyllodes tumour of the breast. Hormones progesterone and oestrogen act on breast epithelium to increase proliferation. For ciswomen, endogenous and exogenous oestrogen exposure over a lifetime is associated with increased risk for certain benign and malignant breast pathologies. Transwomen taking hormonal therapy may also be at an increased risk of breast disease.
Classic paroxysmal nocturnal haemoglobinuria presenting with intestinal malabsorption syndrome, acute abdomen and acute kidney injury
Authors: Porel Rajdeep , Kumar Anjani , Ajit Surabhi , Ojha Vishnu Shankar , Biswas Ratnadeep
Published: March 2024

A male patient in his 30s presented with complaints of acute abdominal pain, black stools and red-coloured urine. CT revealed thrombi in the splenic and left renal veins, leading to infarctions. An endoscopy displayed scalloping of the duodenal folds, indicative of intestinal malabsorption syndrome (IMS). Histopathological examination confirmed IMS. Due to the presence of intravascular haemolysis, haemoglobinuria and thrombotic complications, paroxysmal nocturnal haemoglobinuria (PNH) was suspected and subsequently confirmed by flow cytometry. Thus, a diagnosis of classic PNH with IMS and thrombotic complications was established. This unique case highlights the coexistence of PNH and IMS, resembling the complement hyperactivation, angiopathic thrombosis and protein-losing enteropathy disease, suggesting potential shared pathophysiology.
Cushing’s syndrome diagnosed incidentally on CT imaging
Authors: Gillis Timber , Low Gavin , Wilson Mitchell P
Published: March 2024

In this case report, we describe an uncommon presentation of Cushing’s syndrome in a patient in their 60s who presented to the emergency department with left-sided chest pain. The initial workup for the patient was unremarkable except for an elevated blood pressure and elevated fasting plasma glucose. A CT scan of the chest, abdomen and pelvis was performed, demonstrating a splenic artery thrombus with multiple splenic infarcts, in addition to a combination of macronodular adrenal hyperplasia, bilateral gynecomastia, centripetal fat distribution and suspected mild bone demineralisation. Adrenocorticotropic hormone-independent macronodular adrenal hyperplasia, a rare aetiology responsible for Cushing’s syndrome, was raised as a potential unifying diagnosis for the patient’s hypercoagulable status, which was subsequently confirmed on an endocrinological investigation. The case report underscores the importance of communicating clinically relevant details to the imaging specialist in combination with considering a broad differential, including endocrine disorders, when evaluating an undifferentiated patient with atypical imaging findings.
External validation and application of the Diabetes Population Risk Tool (DPoRT) for prediction of type 2 diabetes onset in the US population
Authors: Kornas Kathy , Tait Christopher , Negatu Ednah , Rosella Laura C
Published: March 2024

Introduction

Characterizing diabetes risk in the population is important for population health assessment and diabetes prevention planning. We aimed to externally validate an existing 10-year population risk model for type 2 diabetes in the USA and model the population benefit of diabetes prevention approaches using population survey data.

Research design and methods

The Diabetes Population Risk Tool (DPoRT), originally derived and validated in Canada, was applied to an external validation cohort of 23 477 adults from the 2009 National Health Interview Survey (NHIS). We assessed predictive performance for discrimination (C-statistic) and calibration plots against observed incident diabetes cases identified from the NHIS 2009–2018 cycles. We applied DPoRT to the 2018 NHIS cohort (n=21 187) to generate 10-year risk prediction estimates and characterize the preventive benefit of three diabetes prevention scenarios: (1) community-wide strategy; (2) high-risk strategy and (3) combined approach.

Results

DPoRT demonstrated good discrimination (C-statistic=0.778 (males); 0.787 (females)) and good calibration across the range of risk. We predicted a baseline risk of 10.2% and 21 076 000 new cases of diabetes in the USA from 2018 to 2028. The community-wide strategy and high-risk strategy estimated diabetes risk reductions of 0.2% and 0.3%, respectively. The combined approach estimated a 0.4% risk reduction and 843 000 diabetes cases averted in 10 years.

Conclusions

DPoRT has transportability for predicting population-level diabetes risk in the USA using routinely collected survey data. We demonstrate the model’s applicability for population health assessment and diabetes prevention planning. Our modeling predicted that the combination of community-wide and targeted prevention approaches for those at highest risk are needed to reduce diabetes burden in the USA.
Descriptive study of the challenges when implementing an app for patients with neovascular age-related macular degeneration to monitor their vision at home
Authors: Reeves Barnaby C , Wickens Robin , O’Connor Sean R , Gidman Eleanor Alma , Ward E , Treanor Charlene , Peto Tunde , Burton Ben J L , Knox Paul C , Lotery Andrew , Sivaprasad Sobha , Donnelly Michael , Rogers Chris A , Hogg Ruth E
Published: March 2024

Objectives

Remote monitoring of health has the potential to reduce the burden to patients of face-to-face appointments and make healthcare more efficient. Apps are available for patients to self-monitor vision at home, for example, to detect reactivation of age-related macular degeneration (AMD). Describing the challenges when implementing apps for self-monitoring of vision at home was an objective of the MONARCH study to evaluate two vision-monitoring apps on an iPod Touch (Multibit and MyVisionTrack).

Design

Diagnostic Test Accuracy study.

Setting

Six UK hospitals.

Methods

The study provides an example of the real-world implementation of such apps across health sectors in an older population. Challenges described include the following: (1) frequency and reason for incoming calls made to a helpline and outgoing calls made to participants; (2) frequency and duration of events responsible for the tests being unavailable; and (3) other technical and logistical challenges.

Results

Patients (n=297) in the study were familiar with technology; 252/296 (85%) had internet at home and 197/296 (67%) had used a smartphone. Nevertheless, 141 (46%) called the study helpline, more often than anticipated. Of 435 reasons for calling, all but 42 (10%) related to testing with the apps or hardware, which contributed to reduced adherence. The team made at least one call to 133 patients (44%) to investigate why data had not been transmitted. Multibit and MyVisionTrack apps were unavailable for 15 and 30 of 1318 testing days for reasons which were the responsibility of the app providers. Researchers also experienced technical challenges with a multiple device management system. Logistical challenges included regulations for transporting lithium-ion batteries and malfunctioning chargers.

Conclusions

Implementation of similar technologies should incorporate a well-resourced helpline and build in additional training time for participants and troubleshooting time for staff. There should also be robust evidence that chosen technologies are fit for the intended purpose.

Trial registration number

ISRCTN79058224.
Coutilisation of oral rehydration solution and zinc for treating diarrhoea and its associated factors among under-five children in East Africa: a multilevel robust Poisson regression
Authors: Legesse Bruck Tesfaye , Wondie Wubet Tazeb , Gedefaw Gezahagn Demsu , Workineh Yakob Tadese , Seifu Beminate Lemma
Published: March 2024

Objective

This study aimed to assess the coutilisation of oral rehydration solution (ORS) and zinc for treating diarrhoea and its associated factors among under-5 children in East Africa.

Design

Cross-sectional study design. Multilevel Poisson regression analysis with robust variance was fitted to identify predictors of zinc and ORS coutilisation. An adjusted prevalence ratio (aPR) with a 95% CI was reported to declare the statistical significance.

Setting

Twelve East African countries.

Participants

16 850 under-5 children who had diarrhoea were included in the study.

Result

In East African nations, the coutilisation of ORS and zinc for the treatment of diarrhoea in children under 5 was 53.27% with a 95% CI (52.54% to 54.01%). Children of mothers with primary education (aPR 1.15, 95% CI 1.09 to 1.20), secondary education (aPR 1.08, 95% CI 1.02 to 1.14), higer education (aPR 1.19, 95% CI 1.10 to 1.29), those from maternal age category of 20–24 (aPR 1.14, 95% CI 1.07 to 1.21), age category of 25–29 (aPR 1.13, 95% CI 1.06 to 1.21), age category of 30–34 (aPR 1.09, 95% CI 1.02 to 1.16), those from wealthy households (aPR 1.04, 95% CI 1.01 to 1.09) and those who have a media exposure (aPR 1.04, 95% CI 1.01 to 1.08) were more likely to receive combination.

Conclusion

Only half of the under-5 children with diarrhoea in East Africa were treated with a combination of ORS and zinc. To increase the use of the suggested combination therapy of ORS with zinc, it is important to empower women through education and prevent teen pregnancy.
Codesigning enhanced models of care for Northern Australian Aboriginal and Torres Strait Islander youth with type 2 diabetes: study protocol
Authors: Kirkham Renae , Puszka Stefanie , Titmuss Angela , Freeman Natasha , Weaver Emma , Morris Jade , Mack Shiree , O'Donnell Vicki , Boffa John , Dowler James , Ellis Elna , Corpus Sumaria , Graham Sian , Scott Lydia , Sinha Ashim K , Connors Christine , Shaw Jonathan E , Azzopardi Peter , Brown Alex , Davis Elizabeth , Wicklow Brandy , Maple-Brown Louise
Published: March 2024

Introduction

Premature onset of type 2 diabetes and excess mortality are critical issues internationally, particularly in Indigenous populations. There is an urgent need for developmentally appropriate and culturally safe models of care. We describe the methods for the codesign, implementation and evaluation of enhanced models of care with Aboriginal and Torres Strait Islander youth living with type 2 diabetes across Northern Australia.

Methods and analysis

Our mixed-methods approach is informed by the principles of codesign. Across eight sites in four regions, the project brings together the lived experience of Aboriginal and Torres Strait Islander young people (aged 10–25) with type 2 diabetes, their families and communities, and health professionals providing diabetes care through a structured yet flexible codesign process. Participants will help identify and collaborate in the development of a range of multifaceted improvements to current models of care. These may include addressing needs identified in our formative work such as the development of screening and management guidelines, referral pathways, peer support networks, diabetes information resources and training for health professionals in youth type 2 diabetes management. The codesign process will adopt a range of methods including qualitative interviews, focus group discussions, art-based methods and healthcare systems assessments. A developmental evaluation approach will be used to create and refine the components and principles of enhanced models of care. We anticipate that this codesign study will produce new theoretical insights and practice frameworks, resources and approaches for age-appropriate, culturally safe models of care.

Ethics and dissemination

The study design was developed in collaboration with Aboriginal and Torres Strait Islander and non-Indigenous researchers, health professionals and health service managers and has received ethical approval across all sites. A range of outputs will be produced to disseminate findings to participants, other stakeholders and the scholarly community using creative and traditional formats.
Inpatient deaths by medical service: characteristics in a comprehensive cancer centre
Authors: Mercadante Sebastiano , Lo Cascio Alessio , Casuccio Alessandra
Published: March 2024

Aim

To examine the intensity of care in the last 3 days of life in different medical settings of a comprehensive cancer centre.

Methods

In this retrospective study, the charts of patients who died in hospital from July 2019 to June 2023 were reviewed. The units taken into consideration were acute palliative care unit (APCU), oncology (ONC) and haematology (HEM), which included also the transplantation unit. Age, gender, diagnosis, Karnofsky or Eastern Cooperative Oncology Group, drugs used in the last 3 days of life, respiratory support, transfusion, parenteral nutrition, imaging studies, blood gas analysis, biochemistry, consultations and endoscopy were retrieved.

Results

Data on 177 patients who died in the period taken into consideration were reviewed. APCU was characterised by more frequent use of opioids, midazolam and scopolamine butylbromide. On the other side, HEM was characterised by higher use of vasoactive drugs, antibiotics, transfusions, imaging studies, growth factors, consultations, biochemistry, blood gas analysis, parenteral nutrition and ventilatory support. ONC was characterised by the larger use of anticoagulants and ventilatory support.

Conclusion

A more aggressive treatment was performed in HEM, as denoted by a large use of life-sustaining treatments and investigations. Taken together, these data show that the way to die is different depending on the setting of care. End-of-life funnel is similar for every dying patient and choices should be based on short prognosis and expectation rather than on disproportionate and afinalistic treatments.
A two-tensor model with order-three
Authors: Kang Bei , Wang Lu-Yao , Wu Ke , Zhao Wei-Zhong
Published: March 2024

We construct a two-tensor model with order-3 and present its W-representation. Moreover we derive the compact expressions of correlators from the W-representation and analyze the free energy in large N limit. In addition, we establish the correspondence between two colored Dyck walks in the Fredkin spin chain and tree operators in the ring. Based on the classification Dyck walks, we give the number of tree operators with the given level. Furthermore, we show the entanglement scaling of Fredkin spin chain beyond logarithmic scaling in the ordinary critical systems from the viewpoint of tensor model.
A Lightweight CNN Based on Memristive Stochastic Computing for Electronic Nose
Authors: Yang Bin , Chen Tao , Chen Ai , Duan Shukai , Wang Lidan
Published: March 2024

Gas detection plays different roles in different environments. Traditional algorithms implemented on electronic nose for gas detection and recognition have high complexity and cannot resist device drift. In response to the above issues, we propose a convolutional neural network based on memristive Stochastic Computing (SC), which combines the characteristics of small devices and low power consumption of memristor devices, as well as the fast and fault-tolerant random calculation speed. It can effectively utilize hardware advantages, recognizing gases by electronic nose. The experimental results show that for two different gas sensor array datasets, the accuracy of the proposed method can achieve the level of 99%. When using memristive SC for deduction, the accuracy decreases by less than 1%, but in drift data, the accuracy can be improved by about 3%. Finally, the improvement in area, power, and energy compared to inference in GPU (NVIDIA Geforce RTX 3060 Laptop) is 1104X, 48X, and 9X, respectively.
Bifurcations and Exact Solutions of a Cantilever Beam Vibration Model Without Damping and Forced Terms
Authors: Zhuang Jinsen , Chen Guanrong , Li Jibin
Published: March 2024

For the cantilever beam vibration model without damping and forced terms, the corresponding differential system is a planar dynamical system with some singular straight lines. In this paper, by using the techniques from dynamical systems and singular traveling wave theory developed by [ Li & Chen, 2007 ] to analyze its corresponding differential system, the bifurcations and the dynamical behaviors of the corresponding phase portraits are identified and analyzed. Under different parameter conditions, exact homoclinic and heteroclinic solutions, periodic solutions, compacton solutions, as well as peakons and periodic peakons, are all found explicitly.
On the combinatorial rank of quantum groups of type F4
Authors: Dylewski Vanusa , Pogorelsky Bárbara , Renz Carolina
Published: March 2024

In this paper, we calculate the combinatorial rank of the positive part [Formula: see text] of the multiparameter version of the small Lusztig quantum group, where [Formula: see text] is a simple Lie algebra of type [Formula: see text]. For this purpose, we also present the basis and relations of the quantum algebra, calculate the coproduct of its PBW-generators and determine all skew-primitive elements of this quantum group. In conclusion, we obtain that the combinatorial rank of [Formula: see text] is 4.
On the diameter of Engel graphs
Authors: Lucchini Andrea , Spiga Pablo
Published: March 2024

Given a finite group [Formula: see text], the Engel graph of [Formula: see text] is a directed graph [Formula: see text] encoding pairs of elements satisfying some Engel word. Namely, [Formula: see text] is the directed graph, where the vertices are the non-hypercentral elements of [Formula: see text] and where there is an arc from [Formula: see text] to [Formula: see text] if and only if [Formula: see text] for some [Formula: see text]. From previous work, it is known that, except for a few exceptions, [Formula: see text] is strongly connected. In this paper, we give an absolute upper bound on the diameter of [Formula: see text], when [Formula: see text] is strongly connected.
The degree of aortic occlusion in the setting of trauma alters the extent of acute kidney injury associated with mitochondrial preservation
Authors: Abel Biebele , Mares John , Hutzler Justin , Parajuli Babita , Kurada Lalitha , White Joseph M. , Propper Brandon W. , Stewart Ian J. , Burmeister David M.
Published: March 2024

Large animal models of ischemia-reperfusion acute kidney injury (IR-AKI) are lacking. This report establishes a titratable IR-AKI model in swine in which a balloon catheter can be used to alter distal pressures experienced by the kidney, thus controlling renal blood flow. Lower blood flow results in greater renal dysfunction and structural damage, as well as lower mitochondrial biomass, elevated systemic inflammation, and vascular dysfunction.
Evaluation of Preplant Seed Protectants for the Management of Root-Knot Nematode of Okra in Ghana
Authors: Baah Prince , Nyaku Seloame T. , Agamah Benjamin , Tongoona Pangirayi B.
Published: March 2024

Root-knot nematode (Meloidogyne incognita) poses a significant threat to okra production, resulting in substantial yield losses. The objectives of this study were to assess the impact of biological seed protectants on the growth and establishment of okra plants and nematode population reduction in soil. Okra seeds were coated with 40% sesame oil, 50% neem oil, 100% citrus oil, velum at 3.8 ml/7l of water, and a control (sterilized distilled water) at different time intervals of 30 min, 60 min, 90 min, and 120 min to determine the germination percentages and vigor. The experimental setup was laid out in a completely randomized design (CRD), with three replications, utilizing a Jacobson table for the germination test. The laboratory results demonstrated significant differences (P<0.05) in germination percentage and vigor index across the different time intervals. Neem oil, citrus oil, and velum exhibited higher germination percentages and vigor indices at all time intervals. Notably, 30-minute time interval proved to be efficient with 100% citrus oil producing 80.33% germination and 965 vigor index and 50% neem oil producing 75% germination and 994 vigor index. Field evaluations revealed citrus at 100% concentrations as seed coating (T5) and neem at 50% concentrations as seed coating (T3), with the highest nematode reductions (90.1% and 90.4%) and least reproductive factors (RFs) of 0.05 and 0.04, respectively, at the Atomic farms. The study has revealed that treating okra seeds with 100% citrus oil and 50% neem oil has the efficacy of reducing nematode reproduction in soil, while enhancing germination and seedling vigor, together with an improvement in growth and yield. Sesame oil has a negative influence on seed germination and vigor and is therefore not recommended as a preplant protectant.
Multistaged In Silico Discovery of the Best SARS-CoV-2 Main Protease Inhibitors amongst 3009 Clinical and FDA-Approved Compounds
Authors: Eissa Ibrahim H. , Saleh Abdulrahman M. , Al-Rashood Sara T. , El-Attar Abdul-Aziz M. M. , Metwaly Ahmed M.
Published: March 2024

As a follow-up to our teamwork’s former work against SARS-CoV-2, eight compounds (ramelteon (68), prilocaine (224), nefiracetam (339), cyclandelate (911), mepivacaine (2325), ropivacaine (2351), tasimelteon (2384), and levobupivacaine (2840)) were revealed as the best potentially active SARS-CoV-2 inhibitors targeting the main protease (PDB ID: 5R84), Mpro. The compounds were named in the midst of 3009 FDA and clinically approved compounds employing a multistaged in silico method. A molecular fingerprints study with GWS, the cocrystallized ligand of the Mpro, indicated the resemblance of 150 candidates. Consequently, a structure similarity experiment disclosed the best twenty-nine analogous. Then, molecular docking studies were done against the Mpro active site and showed the binding of the best compounds. Next, a 3D-pharmacophore study confirmed the obtained results for the eight compounds by exhibiting relative fit values of more than 90% (except for 68, 74%, and 2384, 83%). Levobupivacaine (2840) showed the most accurate docking and pharmacophore scores and was picked for further MD simulations experiments (RMSD, RMSF, Rg, SASA, and H-H bonding) over 100 ns. The MD simulations results revealed the accurate binding as well as the optimum dynamics of the Mpro-levobupivacaine complex. Finally, MM-PBSA studies were conducted and indicated the favorable bonding of the Mpro-levobupivacaine complex with a free energy value of −235 kJ/mol. The fulfilled outcomes hold out hope of beating COVID-19 through more in vitro and in vivo research for the named compounds.
Case and Management Considerations of Low‐Grade Cystic Duct Stump Dysplasia after Laparoscopic Cholecystectomy
Authors: Ufongene Claire , Kunaprayoon Saran , Mestre Juan
Published: March 2024

Cholecystectomies have become one of the more commonly practiced procedures. As a result, there has been a rise in neoplastic changes in excised specimens. Due to this, surgeons must be prepared to manage possible malignancy after resecting what was previously thought to be a benign gallbladder. While management for high‐grade dysplasia has been more clearly laid out in literature, data on management of low‐grade dysplasia are limited. Here, we report a novel case of a 46‐year‐old woman with an incidental low‐grade dysplasia of the cystic duct stump after a laparoscopic cholecystectomy for biliary colic. The decision was made to excise the remaining stump without further surveillance postoperatively given benign pathology findings. More documented cases and their management and ultimately longitudinal cohort studies will help facilitate the creation of guidelines for managing this particular pathology.
Cholesterol Modifies Nutritional Values and Flavor Qualities in Female Swimming Crab (Portunus trituberculatus)
Authors: Zhu Tingting , Jin Min , Peng Hongyu , Zhao Wenli , Shen Yuedong , Xie Shichao , Zhou Qicun
Published: March 2024

The quality of crustacean aquatic products is affected by feed. Cholesterol (CHO), an essential element for crustacean growth, has been widely supplemented in diet, but its food quality regulation remains unclear. The study aimed to investigate the effects of different dietary CHO levels (0.12%, 1.00%, and 2.50%) on the nutritional value and flavor quality in the edible parts of female swimming crabs (Portunus trituberculatus). Results showed that dietary CHO levels significantly increased lipid content in the hepatopancreas and promoted the accumulation of n‐3 long‐chain polyunsaturated fatty acids (LC‐PUFA) in the hepatopancreas and muscle by activating the gene expression related to biosynthesis pathways. However, with dietary CHO levels increased, protein content in muscle decreased significantly. This may be related to dietary CHO supplementation (especially 2.50% CHO level) suppressed amino acid accumulation in the hepatopancreas and muscle by downregulating the target of the rapamycin pathway and upregulating amino acid catabolism‐related genes. Moreover, 1.00% CHO treatment had higher relative levels of volatiles, producing grassy, fruity, and fatty odors in muscle, which may be due to the upregulation of the branched‐chain amino acid transaminase (bcat) expression level. Dietary CHO weakened nucleotide and free amino acid accumulation in hepatopancreas and muscle. Overall, this study suggests that dietary 1.00% CHO level had higher LC‐PUFA and pleasing flavor substances in muscle but was not conducive to hepatopancreatic protein and flavor nucleotide deposition of swimming crab.
An Efficient Local Artificial Boundary Condition for Infinite Long Finite Element Euler–Bernoulli Beam
Authors: Zheng Zijun , Pang Gang
Published: March 2024

To solve the wave propagation problems of the Euler–Bernoulli beam in an unbounded domain effectively and efficiently, a new local artificial boundary condition technology is proposed. It replaces the residual right‐hand side of the truncated discrete equation with an equivalent linear algebraic system. First, the equivalent Schrodinger equation is discussed. Its artificial boundary condition is obtained by first rationalizing the Dirichlet‐to‐Neumann condition in the frequency domain with a Pade approximation and then inverse transforming each Pade term back into the time domain by introducing auxiliary degrees of freedom. Frequency shifting is employed such that it performs better near a prescribed frequency. Then, the artificial boundary condition of the finite element Euler–Bernoulli beam is obtained by simple algebraic manipulations on that of the corresponding Schrodinger equation. This method only makes local changes to the original truncated discrete dynamic system and thus is very efficient and easy to use. The accuracy of the proposed method can be improved by using more Pade terms and a proper shift frequency. The numerical example shows, with only a few additional degrees of freedom, the proposed artificial boundary condition effectively eliminates the spurious reflection. The idea of the proposed method can also be used in other dispersive wave systems.
Rare Case Studies of Bilateral and Symmetric Sacroiliac Disease
Authors: Soloway Stephen , Soloway Alyxandra M. , Chin Tyler G. , Lieske Timothy
Published: March 2024

Introduction. Inflammatory sacroiliitis is common in rheumatology practice. Spondyloarthritis is often underdiagnosed due to the lack of proper evaluation of the sacroiliac joints (SIJs), clinically and radiographically. If SIJ is inflamed or arthritic, the arthritic said patient typically has spondyloarthritis, in the absence of infections or crystal arthritis. Sacroiliitis, in particular, when diagnosed between 12 and 45 years of age, is indicative of spondyloarthritis. People are often misdiagnosed and mislabeled as fibromyalgia because their serologies are negative. Our goal is to point out the importance of proper evaluation, diagnosis, and importance of inflammatory SIJ disease and conditions that involve SIJ inflammation. Cases. We present three rare conditions presenting with bilateral and symmetric SIJ disease, none of which is ankylosing spondylitis, Crohn’s colitis, ulcerative colitis, psoriatic arthritis, and reactive arthritis (Reiter syndrome); there are reports of concurrent SIJ disease in rheumatoid arthritis and SLE. Conclusion. The authors believe that SIJ disease is overlooked, is underdiagnosed, and can lead to incorrect treatment. We suggest a greater focus on SIJ imaging in the diagnosis and treatment of unexplained illnesses associated with low back pain, morning stiffness, or unexplained buttock pain. Providers should review their own SIJ films. The meaning of SIJ widening, cortical irregularity, spurs, and the significance of the anterior inferior SI joints, bone marrow edema, and fusion (namely, the natural history of sacroiliac pathophysiology).
Supplementary Figure 3 from CALGB 80802 (Alliance): Impact of Sorafenib with and without Doxorubicin on Hepatitis C Infection in Patients with Advanced Hepatocellular Carcinoma
Authors: Abou-Alfa Ghassan K. , Geyer Susan M. , Nixon Andrew B. , Innocenti Federico , Shi Qian , Kumthekar Priya , Jacobson Sawyer , El Dika Imane , Yaqubie Amin , Lopez Juan , Huang Binhui , Tang Yi-Wei , Wen Yujia , Schwartz Lawrence H. , El-Khoueiry Anthony B. , Knox Jennifer J. , Rajdev Lakshmi , Bertagnolli Monica M. , Meyerhardt Jeffrey A. , O'Reilly Eileen M. , Venook Alan P.
Published: March 2024

Supplementary Figure 3. Kaplan-Meier curves for the progression-free survival distributions for patients who have detectable (HCV-D) vs. undetectable (HCV-UN) HCV titer levels on their first evaluated sample, by treatment arm.
Figure S12 from Drug-resilient Cancer Cell Phenotype Is Acquired via Polyploidization Associated with Early Stress Response Coupled to HIF2α Transcriptional Regulation
Authors: Carroll Christopher , Manaprasertsak Auraya , Boffelli Castro Arthur , van den Bos Hilda , Spierings Diana C.J. , Wardenaar René , Bukkuri Anuraag , Engström Niklas , Baratchart Etienne , Yang Minjun , Biloglav Andrea , Cornwallis Charlie K. , Johansson Bertil , Hagerling Catharina , Arsenian-Henriksson Marie , Paulsson Kajsa , Amend Sarah R. , Mohlin Sofie , Foijer Floris , McIntyre Alan , Pienta Kenneth J. , Hammarlund Emma U.
Published: March 2024

Figure S12: Survival of polyploid cells is reduced by the addition of NOTCH inhibitor during cisplatin treatment.
FIGURE 5 from Drug-resilient Cancer Cell Phenotype Is Acquired via Polyploidization Associated with Early Stress Response Coupled to HIF2α Transcriptional Regulation
Authors: Carroll Christopher , Manaprasertsak Auraya , Boffelli Castro Arthur , van den Bos Hilda , Spierings Diana C.J. , Wardenaar René , Bukkuri Anuraag , Engström Niklas , Baratchart Etienne , Yang Minjun , Biloglav Andrea , Cornwallis Charlie K. , Johansson Bertil , Hagerling Catharina , Arsenian-Henriksson Marie , Paulsson Kajsa , Amend Sarah R. , Mohlin Sofie , Foijer Floris , McIntyre Alan , Pienta Kenneth J. , Hammarlund Emma U.
Published: March 2024

Surviving polyploid cells demonstrate an overall reduction of chromatin openness while AP-1 motifs were enriched. A, Visualization of accessible regions in surviving HCC1806 cells at 0 DPT; as quantified by ATAC-seq. B, Visualization of more (green) or less (red) accessible regions in surviving HCC1806 cells at 0 DPT; as quantified by ATAC-seq. C, Visualization of DNA motifs for AP-1 family members in HCC1806 surviving at 0 DPT, as quantified by ATAC-seq. D, Openness of region for EPAS1 in HCC1806 cells surviving at 0 DPT, as visualized with genome browser tracks. E, Protein level changes in HCC1806 and HCT116 cells of the AP-1 members FOS, FOSL1, JUN, and ATF-3 in untreated (CTL), surviving cells at 0 DPT, 5 DPT, and 10 DPT, and as progeny. F, Number of HCC1806 and HCT116 cells surviving at 0 DPT and 10 DPT when treated with cisplatin alone and cisplatin together with the FOS/AP-1 inhibitor T-5224 from biological replicates (n = 3) and P-value (∗∗, P < 0.01; ∗, P < 0.05, significant relative to vehicle) by ANOVA test as indicated.
Leiomyosarcoma of the Prostate: Report of Two Cases and Review of the Literature
Authors: Bettaieb Ons , Keskes Aicha , Llacer Moscardo Carmen
Published: March 2024

Introduction: Leiomyosarcoma (LMS) of the prostate is an extremely rare and aggressive tumor that presents with nonspecific signs and symptoms. Treatment guidelines are not yet established. Case Presentation: We report two cases of LMS of the prostate. The presenting symptom was hematuria, and diagnosis was ascertained through a transurethral resection of the prostate for the 2 patients. The treatment course consisted of three courses of chemotherapy with gemcitabine and docetaxel, radical prostatectomy, and postoperative radiation therapy for the first patient and three courses of gemcitabine and radiation therapy of the prostate and the whole pelvis for the second patient. The follow-up of our 2 patients was 9 and 12 months, respectively. Recurrence occurred 10 months after treatment completion for the second case. No recurrence was noticed in the first case. Conclusion: These two cases highlight the importance of a multimodal approach to yield the best outcomes.
“Air That Once Was Breath” Part 1: Wildfire-Smoke-Induced Mechanisms of Airway Inflammation – “Climate Change, Allergy and Immunology” Special IAAI Article Collection: Collegium Internationale Allergologicum Update 2023
Authors: Bowman Willis S. , Schmidt Rebecca J. , Sanghar Gursharan K. , Thompson III George R. , Ji Hong , Zeki Amir A. , Haczku Angela
Published: March 2024

Background: Wildfires are a global concern due to their wide-ranging environmental, economic, and public health impacts. Climate change contributes to an increase in the frequency and intensity of wildfires making smoke exposure a more significant and recurring health concern for individuals with airway diseases. Some of the most prominent effects of wildfire smoke exposure are asthma exacerbations and allergic airway sensitization. Likely due to the delayed recognition of its health impacts in comparison with cigarette smoke and industrial or traffic-related air pollution, research on the composition, the mechanisms of toxicity, and the cellular/molecular pathways involved is poor or non-existent. Summary: This review discusses potential underlying pathological mechanisms of wildfire-smoke-related allergic airway disease and asthma. We focused on major gaps in understanding the role of wildfire smoke composition in the development of airway disease and the known and potential mechanisms involving cellular and molecular players of oxidative injury at the epithelial barrier in airway inflammation. We examine how PM2.5, VOCs, O3, endotoxin, microbes, and toxic gases may affect oxidative stress and inflammation in the respiratory mucosal barrier. We discuss the role of AhR in mediating smoke’s effects in alarmin release and IL-17A production and how glucocorticoid responsiveness may be impaired by IL-17A-induced signaling and epigenetic changes leading to steroid-resistant severe airway inflammation. Key Message: Effective mitigation of wildfire-smoke-related respiratory health effects would require comprehensive research efforts aimed at a better understanding of the immune regulatory effects of wildfire smoke in respiratory health and disease.
A Case of Long-Term Survival with Recurrent Liver Metastases from Gastric Cancer Treated with Nivolumab
Authors: Horiuchi Atsushi , Akehi Shun , Fujiwara Yuta , Kawaharada Sakura , Anai Takayuki
Published: March 2024

Introduction: Improvements in overall survival from advanced gastric cancer have recently been reported with nivolumab. However, few reports have described long-term survival after discontinuing treatment. Case Presentation: A 67-year-old man diagnosed with advanced gastric cancer and abdominal aortic aneurysm initially underwent distal gastrectomy with D2 dissection. Histological examination revealed tub2 and T2N1M0 stage IIA. One month later, endovascular aneurysm repair was performed. Six weeks after gastrectomy, adjuvant chemotherapy with S-1 was started. Six months later, liver metastases were identified and liver segments S1 and S7 were resected. S-1 and oxaliplatin were added postoperatively, but multiple liver metastases recurred. Paclitaxel and ramucirumab, irinotecan, and docetaxel were administered. Liver metastases showed a temporary reduction in size, then enlarged again. Nivolumab was therefore administered and the liver metastases showed a significant reduction in size. The interval between doses gradually increased due to persistent general fatigue. At 28 months after starting nivolumab therapy, bronchitis and adrenal insufficiency appeared, so treatment was discontinued. As of 3.5 years after cessation of nivolumab immunotherapy, tumor regression continued to be maintained. The patient remains alive as of 8 years after recurrence of liver metastases. Conclusion: We encountered a case in which the patient received nivolumab therapy for recurrent liver metastases from gastric cancer and survived long term after discontinuing treatment.
Implicit Bias as a Cognitive Manifestation of Systemic
Racism
Authors: Galvan Manuel J. , Payne B. Keith
Published: March 2024

Explicitly prejudiced attitudes against Black Americans have declined gradually since the 1960s. Yet racial disparities and racial discrimination remain significant problems in the United States. How could discrimination and disparate outcomes remain constant even while racial prejudice decreased? Two prominent explanations have emerged to explain these puzzling trends. Sociologists have proposed that disparities and discrimination are perpetuated by systemic racism, or the policies, practices, and societal structures that disadvantage some racial groups compared with others. Simultaneously, psychologists have proposed that implicit biases may sustain discrimination even in the absence of explicit prejudice. In this essay, we explore newly discovered connections between systemic racism and implicit bias, how they challenge traditional views to reorient our understanding of implicit bias, and how they shed new light on strategies to reduce bias.
Dependent Case by Agree: Ergative in Shawi
Authors: Clem Emily , Deal Amy Rose
Published: March 2024

Ergative and accusative behave as dependent cases insofar as their appearance on a nominal depends on the presence of another nominal in the same domain. Recent work has taken the phenomenon of case dependency to challenge the idea that case is assigned via Agree. Focusing on Shawi (Kawapanan; Peru), we show not only that case dependency can be captured via Agree, but also that doing so opens up a new way of understanding the typology of global case splits. Ergative in Shawi appears when the subject is at least as high as the object on the person hierarchy—a global split—and can be accompanied by explicit realization of the object’s features on the subject (“object agreement on the subject”). We propose that ergative arises in Shawi when a probe on v Agrees with both the object and the subject, transferring object features to the subject; these features are spelled out as ergative case and as object agreement. In general, we show that dependent cases, both ergative and accusative, can be seen as a morphological outcome of Agree between a probe and a second goal, realizing features on that goal that were transferred from a previous goal in an earlier step of Agree.
The Diaspora and Sociopolitical Mobilisations in Nigeria
Authors: Akanle Olayinka
Published: March 2024

Nigeria has a significant body of diasporic nationals. While studies abound on the economic and developmental roles of the diaspora, there is a paucity of research on the sociopolitical mobilisation interfaces of diasporas with their countries of origin. This article contributes to an understanding of the complexities and multiplicities of the roles of the diaspora in their countries of origin, using the case of Nigeria. It also provides alternative interpretations of what forced migration and fake news connote, through the real experiences of diasporic Nigerians. A qualitative study was conducted among sixteen diasporic Nigerians, interviewed in 2021–2022, in the United States of America (USA), Namibia, Australia, South Africa, United Kingdom (UK), Botswana and Republic of Ireland. Primary data was triangulated with autoethnography and secondary data to sufficiently understand the reasons for migration, the constructs of forced migration, roles in national development, the sharing of fake news and sociopolitical mobilisations and protests.
Diaspora Protests and Social Uprisings under Authoritarianism
Authors: Tofangsazi Bashir
Published: March 2024

Expatriate citizens of countries under authoritarian rule have been increasingly engaging in protest against repression in their home countries. Whether such diaspora protests can boost social uprisings inside authoritarian countries, however, is yet to be analysed. I hypothesise that diaspora protests inspire protest against authoritarian rulers inside the home country by reducing political repression or providing the dissidents with a perception of political opportunity. To test this hypothesis, I use Iran as a case study of an authoritarian regime with a sizeable diaspora and notable protest surges in recent decades. Using daily protest data from 1996 to 2018, results show that protests against the Iranian regime by Iranian expatriates were followed by a significant increase in the chance of protest incidence inside Iran. This association is robust to a variety of modelling specifications and independent of the role of transnational organisational links between activists, which has been documented in the literature previously.
It Is Our Motherland Too
Authors: Munas Mohamed
Published: March 2024

Foregrounding fluid processes of group identity re/formation, this article advances the debates on the nature of collective mobilisation among diasporas. Specifically, it contributes to a relatively underexplored diaspora studies sub-field: the role of religion in diasporic identity formation. Empirical material from the immigrant group Muslims of Sri Lankan origin in the United Kingdom indicates that religious identities play a key role in the process of formation of political identities and framing under the concept of one ummah. Further, critical events and crisis situations in places of origin mobilise these groups to form social and solidarity movements. This article contributes to ongoing debates on the constructivist approach to diaspora engagement, which goes beyond the conventional ways of understanding diasporas as ‘dispersed victims’. To this end, I argue that the diasporic characteristics are contingent upon the collective experience and embodiment of crisis situations at home and host sites.
Developed Country Diaspora Strategy Framework
Authors: Birka Ieva , Wasserman Romy
Published: March 2024

As developed countries become more and more interested in implementing diaspora strategies, this article reviews relevant literature for diaspora strategy design and implementation and distils elements of existing typologies into a conceptual framework for evaluating developed country diaspora strategies. The framework is then applied to the evaluation of the diaspora policies of Ireland and Australia, which emerge as examples of engaged versus passive states in relation to their diasporas. Interviews with diaspora engagement practitioners are used to elucidate the policies and practices that underpin diaspora engagement strategies in these countries. The resulting analysis has implications for theorising diaspora engagement and offers practical lessons for other countries looking to connect with their diasporas.
Forced, Fooled or Free Will
Authors: Kumar Khemendra K. , Ali Runaaz , Chand Satish Prakash , Kumar Subashni Lata
Published: March 2024

This paper explores the narratives and counter-narratives of indenture experience in Fiji in the works of Totaram Sanadhya, John Wear Burton, Kenneth Gillion, Brij Lal and Satish Rai. The recruitment of Indian indentured labourers in Fiji began in 1879, much later than in other colonies. Yet the experiences of the labourers in Fiji were not markedly different. The indenture system, or girmit, was considered better than the slave trade, while others regarded it as only a change in name, with regulations to safeguard the colonial interest. The above authors have shown that, from the onset, the recruitment process, the passage from India to Fiji, life on the plantations and the coolie lines, and life after indenture were a duality: either emancipation or victimisation of Indian labourers. This paper highlights the dual nature of the indenture experience in Fiji.
Catalogue of juvenile instars of oribatid mites (Acari: Oribatida)—the next decade (2014–2023)
Authors: NORTON ROY A. , ERMILOV SERGEY G.
Published: March 2024

In its traditional, paraphyletic context (sans Astigmata), oribatid mites comprise more than 11,000 known species (Subías 2022). They are largely fungivores and decomposers in organic horizons of soil and have a plesiotypic ontogeny that includes four active, free-living juvenile instars. In a taxonomically organized 2014 catalogue, we summarized literature resources concerning the 805 species for which ontogenetic data (mainly morphological) were available. Herein, we supplement that catalogue with all data known to us that were published during the intervening decade. These relate to 267 species, of which 165 were described prior to 2014. As in the 2014 catalogue, representation is strongest among: the middle-derivative hyporder Nothrina; brachypyline superfamilies that are affiliated with aquatic, semiaquatic or intertidal environments (Limnozetoidea, Ameronothroidea); some eupheredermous groups (Plateremaeoidea, Damaeoidea); and Ceratozetoidea. Also as in 2014, groups that are underreprented, based on their high known diversity, are the ptyctimous Mixonomata (Euphthiracaroidea, Phthiracaroidea) and the brachypyline superfamilies Oppioidea and Oripodoidea.
Changing It Up: Determining the Nash Equilibria for Major League Baseball Pitchers
Authors: White Dustin R. , Smith Ben O.
Published: March 2024

In order to prevent batters from hitting a pitch, pitchers must decide on a strategic balance of many different pitch types. While each pitcher has preferred pitches (likely those with which he is most confident), he cannot over-utilize his dominant pitches, or batters will be able to gain a strategic advantage in trying to put the ball into play. We analyze Major League Baseball (MLB) pitch data from 2008 to 2018 in order to determine whether or not MLB pitchers are able to reach the theorized mixed-strategy Nash equilibrium given the pitcher’s skill in utilizing each type of pitch. Our data suggests that MLB pitchers are in fact rational, and succeed in reaching the mixed-strategy Nash Equilibrium.
Exploring Public Health Research for Corporate Health Policy: Insights for Business and Society Scholars
Authors: Rojas-Cruz Lilia Raquel , Henriques Irene , Husted Bryan W.
Published: March 2024

Despite the growing interest in societal impact in the business and society literature, there remains a notable gap in research on the impact of health interventions on physical and mental health and social welfare. To address this gap, we shift the unit of analysis to the intervention, akin to the level of analysis used in health research. Drawing on a curated subset of health interventions in the workplace from the public health literature, we argue that management scholars can adopt the methods used by public health scholars to design and assess health interventions. By tapping into the rich insights gained from these studies, management scholars can propose evidence-based interventions and policies that can enhance health outcomes, improve productivity, and cultivate a healthier workplace atmosphere. Collaborating with public health researchers, business and society scholars can help create a new field of research on corporate health policy.