bluuebunny/crossref_metadata_2025 huggingface dataset:
Innovation in a volatile field: An analysis of judges’ comments from journalism awards
Authors: Jones Haley-Georgia
Published: July 2023

Journalism faces increased uncertainty from an ever-shifting digital environment, fragmenting audiences and failing business models. Innovation has been touted as the only way to remain viable and the field now offers a range of professional awards for journalism innovation. This article investigates how the industry is navigating the uncertainty associated with innovation by analysing the judges’ comments from innovation awards. By analysing 45 judges’ comments from five Anglo-American award programmes and one international programme, this article finds that judges praised socially oriented themes, while technological and digital innovations are celebrated in relation to how well they support traditional journalism principles such as serving the public interest. This suggests that, in an uncertain environment, judges of innovation awards construct innovation in relation to traditional journalism principles.
Designing a Habitat for 3D Concrete Printing in Permafrost Regions
Authors: Pinto Duarte Jose , Duarte Gonçalo , Brown Nathan , Nazarian Shadi , Memari Ali , Bilén Sven , Radlinska Aleksandra
Published: July 2023

3D concrete printing has the potential to provide solutions to the global shortage of affordable housing. The technology may be particularly suitable for remote regions, where the shortage of labor and materials present challenges. While most projects have focused on the use the technology to fabricate a structure’s walls, this article describes a research effort aimed at printing the entire structure, including the enclosing surface using only 3D concrete printing. The design of a habitat for the permafrost regions of Alaska is used as a case study. The design approach was to conceive a parametric housing system based on modular units whose form are inspired by traditional vault design and amenable to 3D concrete printing. The proposed design is based on features and reach of the robotic arm printer, the desire to avoid formwork, withstanding applicable loads on the structure, and thermal requirements. While the size of each modular unit is determined by spatial requirements, its exact shape is defined using optimization following structural, thermal, and printing considerations. The printing of a reduced-scale version of the proposed unit validated the design showing its printability.
Prestigio y peculio. Las mujeres de la Casa de Castellnovo y el encumbramiento del linaje
Authors: Salas Benedito Maria
Published: July 2023

El presente trabajo busca analizar la aportación de las mujeres de la Casa de Castellnovo al proceso ascensional experimentado por esta familia durante el siglo XVII. Mujeres poderosas, señoras propietarias y verdaderas estrategas, sus ámbitos de actuación trascendieron los marcos del espacio doméstico para desplegarse en las esferas del prestigio y del patrimonio, portadoras de los bienes y los lazos sociales que hicieron posible la progresión del linaje. Un estudio que se aborda desde una perspectiva biográfica y microanalítica, atendiendo a las trayectorias de las condesas de Laconi y Erill, de doña Jerónima de Alagón y sus hijas –Juana y María–, de doña Teresa del Milà e, indirectamente, a la de doña Beatriz de Borja. Con ello, pretendemos entender las estrategias matrimoniales y patrimoniales llevadas a la práctica en cada generación, relacionándolas con las necesidades experimentadas por la Casa en cada momento histórico y con sus oportunidades de medro. Es desde esta perspectiva que puede apreciarse la verdadera capacidad de la mujer noble para ser portadora de un importante legado material e inmaterial, indispensable para explicar la rápida trayectoria ascensional de los Cardona y Borja, ya fuese dentro del matrimonio o tras los muros del convento. En suma, un estudio que busca extraer de los márgenes a la mujer y situarla en el epicentro del interés investigador para resaltar su papel central en el devenir de su estirpe. Un rol al que podemos aproximarnos mediante la consulta de fuentes documentales de tipología y temática muy diversa y albergada en varios archivos de la geografía hispana y austriaca.
Construir una biografía para trascender los tópicos: la marquesa de Santiago, María Soledad Isidra Rodríguez de los Ríos (1764-1807)
Authors: González Heras Natalia
Published: July 2023

Desde estas páginas, sirviéndonos del enfoque biográfico, que se consolida en los últimos tiempos como una de las formas de escribir Historia que viene aportando excelentes resultados, nos acercaremos a la figura de la marquesa de Santiago, María Soledad Isidra Rodríguez de los Ríos (1764-1807). Poco más que un par de tópicos son los que nos han llegado sobre ella desde la segunda mitad del siglo XVIII hasta el presente; es por ello que consideramos la necesidad de realizar un estudio en profundidad de su figura, que nos permita conocerla y, según prevemos, colocarla en un lugar destacado dentro de la sociedad de su época, gracias a cómo se desempeñó en diferentes facetas de su vida –fundamentalmente la cultural y la familiar–. El análisis de su persona y su contexto, en el Madrid finisecular, nos permitirán lanzar algunas hipótesis acerca del porqué de su negativa consideración en los medios de la época. Esposa dos veces y madre de seis hijos, la sociedad demandaba de ella una serie de conductas que, según la documentación nos indica, transgredió. Logró mantener la tutela de sus hijos menores y, por lo tanto, el control de sus patrimonios, pese a haber contraído segundas nupcias –hecho que se apartaba de la norma y para lo que debió obtener el visto bueno de la máxima autoridad, el rey–. Por otro lado, el mal entendimiento con su segundo marido, le llevó incluso a presentar cargos contra él que avalaran un posible divorcio del matrimonio. Con todo ello, buscamos ofrecer una imagen de la marquesa, en la medida de lo posible, lo más próxima a la realidad y alejada de los tópicos.
Una mujer emprendedora y de prestigio en la ciudad de Braga: Maria Vieira y sus «inversiones» en el ámbito terrenal y en el Más Allá (siglo XVII)
Authors: Lobo de Araújo Maria Marta
Published: July 2023

La intervención de Maria Vieira en el mundo terrenal y en el campo religioso y espiritual, en su condición de mujer casada y viuda, evidencia una enorme implicación, tanto real como simbólica. Esta mujer vivió durante la primera mitad del siglo XVII, en la ciudad de Braga y fue allí donde, junto con su marido, protagonizó una importante actividad social, llegando a ser muy rica y poderosa. La riqueza acumulada les permitió costear numerosas actividades de patronazgo en sectores relevantes, como el social, el asistencial y el religioso. En este periplo de inversiones, quedaron reflejadas las huellas de su vida cotidiana, marcada por sus devociones y afectos y, en particular, por sus opciones de vida, emprendidas en pareja o en solitario, pero dirigidas por sacerdotes parientes suyos. Analfabeta, pero muy inteligente y perspicaz, Vieira se hizo cargo de varias responsabilidades y proyectos, demostrando la capacidad financiera y de liderazgo que poseía en una época en la que se esperaba de las mujeres que vivieran con modestia y fueran sumisas. Este estudio pretende, en primer lugar, dar a conocer la acumulación de riqueza que la rodeaba y, en segundo lugar, analizar su desempeño, tanto en términos materiales como espirituales. Las fuentes analizadas se pueden encontrar en varios archivos públicos y privados de Braga, y su intersección permitió seguir el camino de vida de Maria Vieira y dar a conocer su proceso de movilidad y enriquecimiento social, pasando de hija de comerciantes a mujer de élite. Fruto de este viaje conocimos a una mujer muy prestigiosa y poderosa, que adquirió un poder enorme dentro de su familia, pero también en la ciudad. Los emprendimientos que realizó apuntan a una persona muy dinámica, en una sociedad muy marcada por la Contrarreforma.
Militarización, destrucción urbana y asimilación forzada de ciudades de la Corona de Aragón (1707)
Authors: Pamplona Molina Gerard
Published: July 2023

A raíz de la guerra de Sucesión de la Monarquía Hispánica, los territorios de la Corona de Aragón fueron ocupados militarmente y, jurídicamente, perdieron sus constituciones y fueros. En 1707, el contexto militar salido tras Almansa se volvió favorable a los intereses de Felipe V. En las operaciones posteriores, Xàtiva y Lleida fueron arrasadas y remodeladas por parte de los ejércitos felipistas para adaptarlas a las nuevas necesidades militares y sociopolíticas, lo que generó una nueva realidad que facilitó el sometimiento de los naturales de esos reinos «rebeldes» A partir de las fuentes archivísticas procedentes de España y Francia, complementadas por memorias de los coetáneos y documentación británica, en este trabajo vamos a analizar los mecanismos de dominación social y control político efectuados en las poblaciones de Lleida y Xàtiva después de sus conquistas en 1707. Ahondaremos en la comprensión de los mecanismos represivos y castigo que favorecieron la consolidación de Felipe V en el trono y obtener el control de las zonas hostiles, además de constatar el impacto que tuvieron sus directrices para el devenir de ambas urbes. Complementaremos el análisis mediante una comparación internacional de diferentes casos paradigmáticos del período para enmarcarlos dentro de unos fenómenos represivos de alcance internacional. En su conjunto, esto nos permitirá obtener una visión más precisa sobre las estrategias de control que, mediante la construcción de grandes fortalezas y unas guarniciones militares permanentes, intentaron eliminar cualquier atisbo de disidencia social y abrieron la puerta a un proceso de asimilación sociopolítico.
Navigating the Complexity of Inferior Vena Cava (IVC) Filter Retrieval
Authors: Stibbs Peter
Published: July 2023

Inferior Vena Cava (IVC) filters play a pivotal role in managing thromboembolic diseases. However, their prolonged dwell time can lead to complications such as filter penetration and caval thrombosis, necessitating timely retrieval. The retrieval process can be complex, particularly when filters have become embedded within the venous wall due to the process of endothelialization. This process, influenced by a multitude of factors, results in the filter's integration into the vessel structure. We delve into the biological processes underpinning endothelialization, focusing on the proliferation and migration of endothelial cells, the role of inflammation and extracellular matrix remodeling, and the individual variability in this process. We explore the potential use of larger co-axial sheaths to aid in the retrieval of embedded filters. These sheaths can exert dissection forces at the filter site, facilitating its dislodgement and extraction while minimizing risk of vessel injury. Finally, we discuss the balance of forces - dissection and pull forces - essential for effective filter retrieval. This paper aims to shed light on the complex process of embedded IVC filter retrieval and the potential of using larger co-axial sheaths, emphasizing the need for further research in optimizing these techniques.
Prevalence of immunomodulator use as combination therapy with vedolizumab or ustekinumab in inflammatory bowel disease
Authors: Lutz Megan , Caldera Freddy , Schroeder Katie , Gazis Derek , Crawford Julie M. , Long Millie D. , Barnes Edward L.
Published: July 2023

Introduction:

The benefit of adding an immunomodulator to vedolizumab and ustekinumab remains unclear and may compromise the safety of these biologics. We evaluated prevalence and predictors of immunomodulator use with vedolizumab or ustekinumab in patients with inflammatory bowel disease in a large longitudinal cohort.

Methods:

Clinical information was ascertained from electronic medical records of patients enrolled in TARGET-IBD, a prospective longitudinal observational cohort of patients with IBD at 34 sites. Prevalence of immunomodulator use with vedolizumab, ustekinumab, and anti-TNFs as well as predictors of immunomodulator use with vedolizumab and ustekinumab were estimated. Rates of combination therapy were additionally stratified by time from drug approval.

Results:

4039 adults with IBD were identified, of whom 18.8% were treated with vedolizumab and 13.0% were treated with ustekinumab. Combination therapy with vedolizumab and ustekinumab exceeded 30% (30.7% and 36.2%, respectively) and was more likely in those with perianal disease or previous biologic exposure. Age and presence of extra-intestinal manifestations did not consistently predict use of an immunomodulator. Combination therapy decreased in the years following drug approval.

Discussion:

Combination therapy with vedolizumab or ustekinumab was common and was associated with perianal disease and greater exposure to other biologics, although the practice is decreasing with time. Further data are needed to determine efficacy and safety of combination therapy in patients initiating vedolizumab or ustekinumab for IBD.
Development of Real-Time Fluorescence CRISPR/Cas12a-Based Detection as a Portable Diagnostic System Using Integrated Circuits
Authors: Thairat Chayanit , Kijamnajsuk Puchong , Chotikaprakhan Sutharat , Kuleung Chatuporn , Chen Jyh Jian
Published: July 2023

A solution for achieving high-performance measurements in a space-constrained experimental setup was developed as a portable incubating instrument for real-time fluorescence detection of AvrPi9 gene in rice blast fungus by using a calibrated spectrometer in CRISPR-Cas12a detection. The system demonstrates accurate temperature control with low energy consumption and low deviation of ±0.16 °C from the setpoint temperatures, with high sensitivity and accurate detection within 10 min. The CRISPR-Cas12a detection reaction was demonstrated using AvrPi9 PCR product, crRNAs, LbCas12a and fluorescence-quencher reporter incubating at 37 °C for 10 min. Calibrated C12666MA spectrometer with 480 nm and 520 nm LEDs vs HR4000 reference exhibits low RMS of 0.54 and 1.30 and drift of 6.4 nm and 4.84 nm, respectively indicating high accuracy and reliability in fluorescence detection. Fluorescence signals were observed under an LED transilluminator, while real-time analysis was conducted through spectrometric measurements upon excitation by a 480 nm high-intensity blue LED source. Accuracy of detection between positive, non-template and non-target control was reported with no incidence of false positives observed. The instrument exhibits reliable quantitative detection capabilities with a limit of detection of 3.8 ng of DNA targets that are comparable to when running the same reaction on a commercial real-time PCR, with a detection limit of 1 ng. This study demonstrates that the CRISPR-Cas12a detection method represents a significant breakthrough in molecular diagnostics due to its advantages of rapidity, high sensitivity, and convenience allowing for the development of a compact, and energy-efficient platform that can facilitate real-time on-site diagnostics with accurate temperature control.
Teacher-Made Materials Based on Meaningful Learning to Foster Writing Skills.
Authors: MOSQUERA DUVAN
Published: July 2023

This qualitative action research study explores the contribution of teacher-made materials based on meaningful learning to the development of tenth graders’ writing skills. It was carried out with 35 students at a state-funded school in Florencia - Caquetá, Colombia. The instruments used for data collection were students’ artifacts, teacher’s field notes, and a focus group interview. The findings evince that the implementation of well-informed teacher-made materials based on a Materials Development (MD) framework contributes to the development of the learning activities and fosters language learning and use. Besides, meaningful learning occurs as a result of contextualizing content and localizing and personalizing experiences in the learning activities proposed in the workshop to engage students in their completion. Moreover, the students’ writing skills enhance by scaffolding the construction of their texts through the process approach procedures and the cooperative work, as the learning approach that underpinned the development of the writing activities. Finally, giving and receiving feedback served as the source of learner-learner and teacher-learner identification of the state of progress in students’ writings.
Listening to CLIL Practitioners
Authors: McDougald Jermaine S. , Duarte Gómez Daniela , Quesada Gutiérrez Laura Susana , Sánchez Córdoba Félix Gonzalo
Published: July 2023

Content and Language Integrated Learning (CLIL) is an educational approach that combines linguistic and subject-based learning to develop the necessary competencies for success in a globalized world. A mixed-method study researched how CLIL is implemented in (10) K-11 schools in Bogota, Colombia, collecting data from 121 in-service teachers in private schools using an array of instruments, such as surveys, structured interviews, and semi-structured interviews. Using the grounded theory approach, data analysis showed that the participants had limited awareness of the CLIL approach and principles. Accordingly, the findings revealed that there is a need for more focus on fundamental CLIL concepts and more formalized teacher training programs. Furthermore, context-orientated resources also emerged as a priority amongst participants, considering that schools were merely trying to replicate European models of delivering CLIL without clear adaptations or consideration for the voices of local teachers. As a result, bilingual schools in Bogota, which are more inclined to use CLIL-oriented approaches, should establish a network to facilitate CLIL training programs to equip in-service teachers who are immersed in content and language environments.
Adopción de la segunda lengua, un componente de competitividad en la educación global
Authors: Hernandez Palma Hugo Gaspar , Ojeda-Pertuz Decireth del Carmen , Brito-Chiquillo Johennys Genith
Published: July 2023

Desde 2009, el Ministerio de Educación Nacional de Colombia (MEN) ha liderado la construcción e implementación de políticas educativas en la primera infancia y adolescencia, las cuales parten desde el desarrollo integral del individuo como una estrategia para que los niños menores de 5 años más vulnerables puedan acceder a condiciones de educación adecuadas y oportunas. Con el fin de mejorar la calidad de las políticas educativas en los niveles básicos, medianos y más altos, el Gobierno nacional ha desarrollado el Programa Nacional de Bilingüismo (2004- 2019), un proyecto del Ministerio de Educación desarrollado para fortalecer la competitividad de los ciudadanos colombianos (Baron & Bonilla, 2011). Teniendo en cuenta este propósito, se realiza una reflexión sobre cómo se puede contribuir a dicha política para fomentar la competitividad y el desarrollo económico en el país. Como resultado, se obtuvieron observaciones importantes en relación con los aportes fundamentales del bilingüismo en el progreso de una nación.
Resolución del problema integrado de enrutamiento y gestión de inventarios con múltiples vehículos mediante programación lineal entera mixta
Authors: Hincapié-Londoño Frank Alejandro , García-Guevara Jhonatan Stiven , Toro-Ocampo Eliana Mirledy
Published: July 2023

Contexto: El control y distribución de inventarios son procesos claves en la pérdida tanto de eficiencia como de eficacia en el campo de la logística, a nivel global. Según el Departamento Nacional de Planeación de Colombia, en el año 2020, los rubros de transporte, almacenamiento e inventarios correspondieron al 73,9 % del costo logístico total. La resolución del problema de enrutamiento inventario con múltiples vehículos (IRP) representa una alternativa para hacer que los tiempos de ciclo sean más cortos, más flexibles y menos costosos.
Método: En este artículo se describen y comparan modelos matemáticos de la literatura para el problema base, adaptándolo a su variante con múltiples vehículos y resolviéndolo a través modelos de programación lineal entera mixta, mediante la solución de instancias de baja y media complejidad matemática, planteando dos maneras de gestionar el inventario y tres formas de eliminar la creación de sub-tours. Para obtener los resultados se utiliza el software AMPL en un computador con procesador Intel Core i5-5200U CPU @ 2.2 GHz y 4 GB de RAM, considerando un tiempo máximo de ejecución de una hora.
Resultados:  El modelo de flujos muestra el mejor desempeño en cuanto a tiempos computacionales y calidad de la respuesta con respecto a la política de máximo nivel (ML), y la variante MTZ es el segundo mejor modelo. Por último, la variación general reporta mayores tiempos de ejecución y valores GAP más altos. Los modelos presentan buen desempeño para instancias de pequeño y mediano tamaño.
Conclusiones: En esta investigación se presenta una metodología general que puede ser adaptada a diferentes aplicaciones del problema integrado de inventarios y enrutamiento con múltiples vehículos. Se comprobó que las respuestas generadas son de buena calidad, destacando la eliminación de sub-tours por medio del modelo de flujos y la gestión de inventarios bajo la política ML. Los trabajos futuros deben encaminarse en busca de nuevas alternativas a la optimización exacta, tales como las heurísticas o metaheurísticas, que permitan estar lo más cerca posible del óptimo en tiempos de computación más cortos. Además, se podrían considerar demandas estocásticas y el manejo de productos perecederos, entre otros.
Evaluación de protocolos de síntesis de nanopartículas de cobre u óxidos de cobre
Authors: Acevedo-León Daniela , Ossa-Orozco Claudia Patricia , Torres-López Ana María
Published: July 2023

Contexto: Las nanopartículas de cobre u óxidos de cobre son materiales de interés para la agricultura por sus múltiples propiedades, entre ellas su actividad antimicrobiana, que resulta útil en el control biológico de plagas. Diversos autores han reportado que las nanopartículas con tamaño inferior a 50 nm tienen mayor efecto antimicrobiano. De acuerdo con esto, este estudio tuvo como objetivo comparar diferentes protocolos de síntesis, con el propósito de obtener nanopartículas de cobre u óxidos de cobre de tamaños adecuados para su futura evaluación en el control biológico de especies que comúnmente afectan los cultivos en Colombia.
Método: Se evaluaron cinco protocolos de síntesis, cuatro de ellos clasificados como métodos de síntesis química verde y el otro como síntesis biológica. Las nanopartículas obtenidas fueron caracterizadas mediante espectroscopía UV-Vis, DLS, TEM, FTIR, DRX, SEM y EDS.
Resultados: El protocolo 3, que utiliza sulfato de cobre pentahidratado como sal precursora, ácido ascórbico como agente reductor y almidón como estabilizante, resultó ser el más adecuado, pues con él se obtuvieron nanopartículas esféricas de cobre metálico con un tamaño promedio de 4,5 nm.
Conclusiones: Fue posible comparar las metodologías de obtención de nanopartículas de cobre y óxidos de cobre, analizar el efecto de las condiciones de síntesis en sus características y finalmente obtener un protocolo para sintetizar nanopartículas de cobre con un tamaño adecuado para un potencial uso en aplicaciones de control biológico.
Analysis of approaches to the preparation of social reporting of pharmaceutical enterprises
Authors: Tkachenko N. O. , Horodetska I. Ya. , Levytska O. R.
Published: July 2023

Aim. The work aims are to find and justify unified approaches to social reporting for pharmaceutical enterprises, which would enable the evaluation and comparison of the social activities of organizations across different market segments by all stakeholders.
Materials and methods. Materials are scientific and scientific-methodical publications, regulatory and legislative documents on social responsibility, and information from the official websites of domestic manufacturing pharmaceutical enterprises, which were included in the top 20 marketing organizations by the volume of drugs’ pharmacy sales in 2022, to social reporting. Methods: critical analysis, content analysis, generalization, and interpretation of results.
Results. The study found that while social reporting of pharmaceutical enterprises is an established practice abroad, there is no unified approach to their preparation, resulting in a diverse range of content.
In Ukraine, it was observed that only JSC “Pharmak”, Arterium Corporation, and PJSC RPC “Borshchagivskyi chemical and pharmaceutical plant” publish reports on their corporate social responsibility. Other pharmaceutical companies provide information on their social measures either in management reports or in news. The phenomenon of social reporting of domestic pharmaceutical enterprises and the approaches to its preparation are still in the early stages of development. Therefore, this study proposes a framework for the content of such reports that caters to various stakeholders.
Conclusions. Domestic manufacturing pharmaceutical enterprises apply different criteria and different approaches to inform society about their social activities, making it difficult to compare their contribution to the sustainable development of the country.
It has been established that domestic pharmaceutical manufacturing enterprises need to strengthen their efforts in this direction. The preparation of transparent social reports based on international standards is one of the tools for promoting openness, improving the company’s activities, and ensuring accountability in the context of social responsibility.
Akademicka obyczajowość
Authors: Drozdowicz Zbigniew
Published: July 2023

Customs are powerful environmental determinants that shape and separate one group from many others, often taking generations to evolve. When it comes to academia, it is no different. From the founding of the first universities to our present day, there have been two major components of academic morality that have undergone significant changes: academic institutionalism and academic dissemination of knowledge and skills. It can be difficult to adjust to such changes, especially when certain practices once served our predecessors well but their time has passed. However, with the right mindset and an openness to learning from the past and improving on it, we can ensure that our next colleagues will make the most of what their predecessors have left behind and take their knowledge and skills to the next level.
Zwrot ku codzienności w badaniach nad religią
Authors: Obirek Stanisław
Published: July 2023

Article Turning to everyday life in religion research postulates the need to use a new methodology in the analysis of religion. It was proposed by the French cultural anthropologist Michel de Certeau. It is creatively developed by such anthropologists as Nancy T. Ammerman, Hugh Turpin and Catherine Wanner. In this context, the author points to the limitations of traditional methods of studying Polish religiosity. He also proposes his own way of overcoming these limitations. It is listening to the voice of lay Catholics.
Wolność światopoglądowego wyboru bonusem pluralizmu społeczno-kulturowego
Authors: Libiszowska-Żółtkowska Maria
Published: July 2023

Recenzja książki:Janusz Mariański, Pluralizm społeczno-kulturowy jako megatrend a religijność i moralność. Studium socjologiczne
Wyższa Szkoła Nauk Społecznych z siedzibą w Lublinie, Lublin 2022, ss. 266
Rapid response redevelopment: a study of an English-to-Chinese translation course moving online
Authors: Cook Angela , Dianati Seb , Spinelli Franciele , Lai Yen-Ying
Published: July 2023

In early 2020, the tertiary sector in Australia, as in many other parts of the world, was confronted with a series of unforeseen challenges arising from the coronavirus epidemic. As governments responded to the crisis by implementing increasingly strict social distancing and isolation measures, universities had little choice but to adapt their courses for online delivery. The ensuing chaos and confusion prompted academics and support staff to adapt quickly to changing delivery while continuing to offer high-quality teaching and learning experiences. This mixed-methods study explores the approaches that were adopted in a translation course that moved fully online and examines students’ engagement with and evaluation of the new course design. The findings reveal that it is possible to maintain high levels of student satisfaction by ensuring a clearly structured course design in an online mode with interactive and engaging course materials. This has implications for university lecturers wishing to redesign courses in an online or blended format, especially under time pressure.
Comparison of performance for third order immune photonic transmission link incorporating phase shifters and biased optimized dual parallel Mach–Zehnder modulator
Authors: Berwal Pulkit , Singh Sarika
Published: July 2023

This paper presents a comprehension on the linearization arrangements achieved through dual drive dual parallel Mach–Zehnder (DD-DPMZM) by changing bias voltages of sub-modulators and adjusting phases of RF signals. These arrangements comprise of a DD-DPMZM and electric phase shifters. For single sideband (SSB) modulation in sub-modulators of DD-DPMZM, power at intermodulation is found to be 43 dB and 61 dB for the linearized and convention single modulator link respectively. Thus, 28 dB of improvement in suppression of third order intermodulation distortion is reported for the first arrangement of linearization. For quadrature modulation in upper MZM and optical carrier suppression (OCS) modulation in lower modulator, almost complete suppression of IMD3 terms are demonstrated and found to be better performance arrangement for bias optimized dual parallel Mach–Zehnder modulator based linearization link.
Performance evaluation of a currently in-use dry storage cask design for spent accident tolerant fuel loading case under normal operation condition
Authors: Durdu Habibe Merve , Bulut Acar Banu
Published: July 2023

The aim of this study is to assess the performance of an existing dry storage cask design for accident tolerant fuel loading case and to examine the compliance with the safety limits applied currently for dry storage. In the study, for a dry storage cask design currently in use, criticality calculations, dose rate evaluation and thermal analyses are performed in case of loading with the accident tolerant fuel discharged from a PWR. Firstly, for an accident tolerant fuel selected among the concepts proposed for use in light water reactors, burnup analyses are performed by utilizing the Serpent continuous energy code and spent fuel characteristics are determined. Then, criticality analyzes are carried out by using the Serpent Monte Carlo code for the case of loading the accident tolerant fuel into the selected dry storage cask design. Gamma and neutron dose rates at the outer surface and close distances of the storage cask are determined with the Serpent code. To evaluate the thermal performance of the storage cask, thermal analyzes are performed by using the ANSYS Fluent computational fluid dynamics code. The analysis results are compared with the nuclear safety criteria applied to dry storage casks. Results of the analysis show that the dry storage cask design currently in-use does not exceed the criticality, dose rate and maximum surface temperature limits when loaded with spent accident tolerant fuel.
Long non-coding RNA GNAS-AS1 knockdown inhibits proliferation and epithelial–mesenchymal transition of lung adenocarcinoma cells via the microRNA-433-3p/Rab3A axis
Authors: He Jing , Xi Xiaoxiang , Cao Peng , Zhou Jinxia , Liu Hui , Li Na
Published: July 2023

The goal of this study was to demonstrate the functions and specific mechanism of long non-coding RNA (lncRNA) GNAS-AS1 in lung adenocarcinoma. Levels of lncRNA GNAS-AS1, microRNA (miR)-433-3p, and Rab3A were assessed by quantitative real-time PCR (qRT-PCR). The target-binding sites of lncRNA GNAS-AS1, miR-433-3p, and Rab3A were predicted and confirmed by bioinformatics tool (StarBase) and a dual-luciferase reporter system. Cell proliferation and apoptosis were checked using MTT and flow cytometry, respectively. Additionally, the levels of apoptosis-related and epithelial–mesenchymal transition (EMT)-associated genes in A549 cells were analyzed by qRT-PCR and western blot. We found that lncRNA GNAS-AS1 was upregulated, miR-433-3p was low-expressed, and Rab3A was overexpressed in lung adenocarcinoma tissues and cell lines. LncRNA GNAS-AS1 interacted with miR-433-3p and negatively regulated miR-433-3p levels. Rab3A was a direct target of miR-433-3p. Downregulation of lncRNA GNAS-AS1 remarkably suppressed cell proliferation, promoted cell apoptosis, decreased B-cell lymphoma-2 (Bcl-2) expression, enhanced the Bcl-2-Associated X (Bax) level, promoted E-cadherin expression, and reduced N-cadherin and Rab3A levels. However, the miR-433-3p inhibitor reversed all these findings. Similarly, the inhibitory effects of miR-433-3p mimic on A549 cells were reversed by the Rab3A-plasmid. In conclusion, lncRNA GNAS-AS1 downregulation suppressed lung adenocarcinoma cell proliferation and EMT through the miR-433-3p/Rab3A axis.
Physicochemical stability of durvalumab (Imfinzi®) concentrate for solution in original vials after first opening
Authors: Almasi Jannik , Thiesen Judith , Krämer Irene
Published: July 2023

Objectives

Durvalumab (Imfinzi®), a PD-L1 monoclonal antibody (mAb) medication is available as concentrate (50 mg/mL) for solution for infusion. The summary of product characteristics provides information about the physicochemical stability of ready-to-administer durvalumab preparations (vehicle solution 0.9 % NaCl, G5%), but not about the concentrate after first opening. The objective of this study was to determine the physicochemical stability of durvalumab concentrate for solution after first opening over a period of 28 days.

Methods

Imfinzi® vials were punctured and stored refrigerated (2–8 °C) or at room temperature (20–25 °C) light protected. At predefined time points (day 0, 7, 14, 21, 28) the physicochemical stability of the concentrated solution was determined by ion-exchange/size-exclusion high-performance liquid chromatography (IE-/SE-HPLC) with photodiode array detection and pH measurement. Vials were inspected with regard to changes of color, clarity, and visible particles at any time point.

Results

Regardless of the storage temperature, durvalumab 50 mg/mL solutions remained physiochemically stable for 28 days in punctured vials. The concentrations of durvalumab monomer remained unchanged and no secondary peaks (fragments, aggregates) were observed in any of the SE-HPLC chromatograms. The IE-HPLC test results showed no substantial changes of the peak areas of the main peak and of the acidic and basic charge variants during the whole storage period. Appearance and pH of the test solutions remained unchanged until the end of the study.

Conclusions

Regardless of storage conditions none of the analytical methods indicated physicochemical instability of the intact durvalumab monomer over the 28 days of the study. To avoid microbiological instability storage under refrigeration is recommended.
Data management of process plants as complex systems: systematic literature review and identification of challenges and opportunities
Authors: Layer Max , Leidich Jonathan , Schwoch Sebastian , Saske Bernhard , Neubert Sebastian , Robl Peter , Paetzold-Byhain Kristin
Published: July 2023

Led by the manufacturing industry, virtual replicas of production systems also known as digital twins (DTs) are gradually moving into all areas of industry. Their advantages are characterized by the possibility of product optimization, simulations, improved monitoring and prediction of downtimes and optimized maintenance, to name just a few. The engineering, procurement and construction (EPC) of process plants as mechatronic systems is characterized by a high degree of project-specific modifications and interdisciplinary engineering effort with low reusability, in contrast to unit-production-driven areas such as automotive. This results in a high cost-benefit ratio for the creation of DTs over the life cycle of process plants, especially when suppliers are integrated into the value chain. The objective of this paper is to analyze the state of plant lifecycle management, data exchange and the possibilities of optimized supplier integration during the planning and EPC of process plants regarding DT creation and usage. Three research questions (RQs) were used to narrow down a total of 356 identified publications to 54, which were then examined. The papers covered a variety of topics, including combining discipline-specific models, plant management approaches and the combination of both.
Atticist Lexica and the Interpretation of Comic Language
Authors: Monaco Chiara
Published: July 2023

This study aims to analyse how Atticist lexicographers used ancient sources to problematize their lack of sensitivity to literary contexts. This article focuses on comic passages that are interpreted according to the prescriptive outlook of Atticist lexicographers. I will show how lexicographers’ notes on linguistic correctness betray a general indifference towards the stylistic registers and complex variety of the language of comedy. Two case studies will be investigated: (a) the backdating of koine words and (b) the misinterpretation of comic corrections. The analysis of these two cases shows that lexicographers very often interpreted comic attestations as evidence of regular Greek expressions if this reading served the purpose of censoring or supporting a specific usage, regardless of whether or not the comedians were using a word metaphorically or in a jocular way.
Lucus a non lucendo: Enantiosemy in Ancient Latin Lexicography
Authors: Gitner Adam
Published: July 2023

Enantiosemes, words which express opposed meanings (also called auto-antonyms; e.g.altus, which can mean “high” or “low”, or the English “cleave”, which can mean “cut” or “stick together”), present a practical problem for the lexicographer. My paper surveys enantiosemes as they are explicitly discussed by ancient Roman lexicographers and provides a descriptive typology. Roman scholars distinguish between genuine auto-antonyms, which they sometimes callvoces mediae(e.g.valetudofor “health” or “sickness”), and cases of etymology by antiphrasis (e.g.lucus a non lucendo), whereby a name is given through some kind of opposition. This latter group of etymologies-by-antiphrasis can be further subdivided between cases of euphemism and irony. The paper concludes with a short lexicon of Latin enantiosemes explicitly discussed by ancient sources.
An Ongoing Supplement to Traditional Dictionaries:

WiP –

Words in Progress

and the Contribution of Greek Documentary Papyrology
Authors: D’Angelo Marzia
Published: July 2023

Greek lexicography is in a state of constant evolution thanks to progress in philological studies and, in a special way, to the contribution offered by papyri, which frequently provides us with new words or new meanings of already known words. In this regard, the online, freely consultable database WiP – Words in Progress. Supplementary Lexicon of Ancient Greek aims to collect new or rare words and detail corrections and additions in order to record recent progress in the updating and expansion of Ancient and Byzantine Greek. This contribution aims to describe how the database works, and what advantages it offers compared to traditional dictionaries, with a particular focus on the contribution that Greek documentary papyri offer to Greek lexicography.
Adaptation Shapes Local Cortical Reactivity: From Bifurcation Diagram and Simulations to Human Physiological and Pathological Responses
Authors: Cattani Anna , Galluzzi Andrea , Fecchio Matteo , Pigorini Andrea , Mattia Maurizio , Massimini Marcello
Published: July 2023

Human studies employing intracerebral and transcranial perturbations suggest that the input-output properties of cortical circuits are dramatically affected during sleep in healthy subjects as well as in awake patients with multifocal and focal brain injury. In all these conditions, cortical circuits react to direct stimulation with an initial activation followed by suppression of activity (Off-period) that disrupts the build-up of sustained causal interactions typically observed in healthy wakefulness. The transition to this stereotypical response has important clinical implications, being associated with loss of consciousness or loss of functions. Here, we provide a mechanistic explanation of these findings by means of simulations of a cortical-like module endowed with activity-dependent adaptation and mean-field theory. First, we show that fundamental aspects of the local responses elicited in humans by direct cortical stimulation can be replicated by systematically varying the relationships between adaptation strength and excitation level in the network. Then, we reveal a region in the adaptation-excitation parameter space of crucial relevance for both physiological and pathologic conditions, where spontaneous activity and responses to perturbation diverge in their ability to reveal Off-periods. Finally, we substantiate through simulations of connected cortical-like modules the role of adaptation mechanisms in preventing cortical neurons from engaging in reciprocal causal interactions, as suggested by empirical studies. These modeling results provide a general theoretical framework and a mechanistic interpretation for a body of neurophysiological measurements that bears critical relevance for physiological states as well as for the assessment and rehabilitation of brain-injured patients.
Parabrachial Nucleus Activity in Nociception and Pain in Awake Mice
Authors: Smith Jesse A. , Ji Yadong , Lorsung Rebecca , Breault Macauley S. , Koenig Jeffrey , Cramer Nathan , Masri Radi , Keller Asaf
Published: July 2023

The parabrachial nuclear complex (PBN) is a nexus for aversion and for the sensory and affective components of pain perception. We have previously shown that during chronic pain PBN neurons in anesthetized rodents have amplified activity. We report a method to record from PBN neurons of behaving, head-restrained mice while applying reproducible noxious stimuli. We find that both spontaneous and evoked activity are higher in awake animals compared with urethane anesthetized mice. Fiber photometry of calcium responses from calcitonin-gene-related peptide–expressing PBN neurons demonstrates that these neurons respond to noxious stimuli. In both males and females with neuropathic or inflammatory pain, responses of PBN neurons remain amplified for at least 5 weeks, in parallel with increased pain metrics. We also show that PBN neurons can be rapidly conditioned to respond to innocuous stimuli after pairing with noxious stimuli. Finally, we demonstrate that changes in PBN neuronal activity are correlated with changes in arousal, measured as changes in pupil area.

SIGNIFICANCE STATEMENTThe parabrachial complex is a nexus of aversion, including pain. We report a method to record from parabrachial nucleus neurons of behaving mice while applying reproducible noxious stimuli. This allowed us to track parabrachial activity over time in animals with neuropathic or inflammatory pain. It also allowed us to show that the activity of these neurons correlates with arousal states and that these neurons can be conditioned to respond to innocuous stimuli.
The Conversion of Ambrosio Gonzales
Authors: Calvillo Jonathan
Published: July 2023

Memorialization of Ambrosio Gonzales, a nineteenth-century Methodist convert from New Mexico, has aided in the maintenance and expansion of Latinx Protestantism. Gonzales’s trajectory matters to communal and institutional memories, I argue, because his life was embedded within the very origins of Latinx Protestantism in the Southwest. Moreover, Gonzales became emblematic of Protestantism at a time of westward expansion. Even today, commemorating Gonzales bolsters Latinx Protestant identities and legitimizes missionary efforts. While memorializations of Gonzales have often been symbolic, his life also had long-lasting structural effects on Latinx Protestantism in the West. This article is part of a special issue of Pacific Historical Review, “Religion in the Nineteenth-Century American West.”
Household Gods on the Altar of Freedom
Authors: Tucker-Price Cori
Published: July 2023

In the nineteenth century, the American West was imagined as a place brimming with opportunity and prosperity. While many found material success in places like Gold Rush era California, the relationship that Black Americans had to the region and to what they hoped would be afforded to them in the West was marked by racial exclusion. Drawing upon primary sources that include newspaper clippings and Colored California Convention reports, this article considers the various strategies of resistance that Black western arrivants waged to not only attain material wealth but also agitate for their civil rights. “Household Gods” argues that Black western arrivants used religion and religious rhetoric as an adaptive and subversive strategy to shape conceptions of citizenship discourse, which contributed to how Black westerners sought to make space for themselves within a multiethnic society. This article is part of a special issue of Pacific Historical Review, “Religion in the Nineteenth-Century American West.”
The Role of Traditional Games on Children's Ground Motor and Emotional Ability
Authors: Widiarti Azlina Umi , Anggita Gustiana Mega
Published: July 2023

Abstract. Traditional game is one of the sport activity which has many benefits for body health, psychic, and the surrounding environment such as cultural values that must be preserved. Teaching traditional games to children is very necessary at this time to train their motor and social emotional. The writing method starts from problem identification, literacy study, data analysis, building alternative problem solving, and conclusion. Chracters who formed through traditional games walking unconsciously, and this is which makes children learn with it self without coercion. That’s why traditional games are necessary returned to the main game for children so that children can be created strong character and become the nation’s generation who have high integrity and good characteristic. In conclusion The introduction of traditional games in children is very important and can affect the growth and development of children through motor and social emotional conditions.
Comparison of Dietary Supplements Consumption Between Female University and National Team Sports Athletes in Malaysia.
Authors: Mohd Elias Siti Soraya , Zakaria Nur Syaqina , Mohamad Mohd Izham , Megat Haris Nasution Megat Najmuddin
Published: July 2023

Dietary supplement consumption had already become well known among athletes especially those who were involved in team sports to enhance performances, health benefits, and nutritional strategies. This study aimed to determine the difference in dietary supplement consumption between the female university and national team sports athletes in Malaysia. The Dietary Supplement Questionnaire was used to compare the participants’ dietary supplements usage and it was distributed online via a Google Form. Results from this study showed there was no significant difference in the usage of individual vitamins/minerals. However, based on frequency, the usage of vitamin C was the most popular among these groups. Next, there was a significant difference in the usage of protein powder (t = -2.435, df = 61, p <0.018) and, creatine (t = -2.192, df = 61, p <0.032) between the female university and national athletes. After that, there was a significant difference in usage of other supplements and sports aid which was fish oil/omega 3 (t = -1.466, df = 61, p < 0.032). The national athletes showed higher consumption of dietary supplements compared to the university athletes due to their higher level of competition, energy requirement, and long-time of training.