bluuebunny/crossref_metadata_2025 huggingface dataset:
Detection of Total Hip Replacement Loosening Based on Structure-Borne Sound: Influence of the Position of the Sensor on the Hip Stem
Authors: Schumacher Nico , Geiger Franziska , Spors Sascha , Bader Rainer , Haubelt Christian , Kluess Daniel
Published: July 2024

Accurate detection of implant loosening is crucial for early intervention in total hip replacements, but current imaging methods lack sensitivity and specificity. Vibration methods, already successful in dentistry, represent a promising approach. In order to detect loosening of the total hip replacement, excitation and measurement should be performed intracorporeally to minimize the influence of soft tissue on damping of the signals. However, only implants with a single sensor intracorporeally integrated into the implant for detecting vibrations have been presented in the literature. Considering different mode shapes, the sensor’s position on the implant is assumed to influence the signals. In the work at hand, the influence of the position of the sensor on the recording of the vibrations on the implant was investigated. For this purpose, a simplified test setup was created with a titanium rod implanted in a cylinder of artificial cancellous bone. Mechanical stimulation via an exciter attached to the rod was recorded by three accelerometers at varying positions along the titanium rod. Three states of peri-implant loosening within the bone stock were simulated by extracting the bone material around the titanium rod, and different markers were analyzed to distinguish between these states of loosening. In addition, a modal analysis was performed using the finite element method to analyze the mode shapes. Distinct differences in the signals recorded by the acceleration sensors within defects highlight the influence of sensor position on mode detection and natural frequencies. Thus, using multiple sensors could be advantageous in accurately detecting all modes and determining the implant loosening state more precisely.
Single Image Super-Resolution via Wide-Activation Feature Distillation Network
Authors: Su Zhen , Wang Yuze , Ma Xiang , Sun Mang , Cheng Deqiang , Li Chao , Jiang He
Published: July 2024

Feature extraction plays a pivotal role in the context of single image super-resolution. Nonetheless, relying on a single feature extraction method often undermines the full potential of feature representation, hampering the model’s overall performance. To tackle this issue, this study introduces the wide-activation feature distillation network (WFDN), which realizes single image super-resolution through dual-path learning. Initially, a dual-path parallel network structure is employed, utilizing a residual network as the backbone and incorporating global residual connections to enhance feature exploitation and expedite network convergence. Subsequently, a feature distillation block is adopted, characterized by fast training speed and a low parameter count. Simultaneously, a wide-activation mechanism is integrated to further enhance the representational capacity of high-frequency features. Lastly, a gated fusion mechanism is introduced to weight the fusion of feature information extracted from the dual branches. This mechanism enhances reconstruction performance while mitigating information redundancy. Extensive experiments demonstrate that the proposed algorithm achieves stable and superior results compared to the state-of-the-art methods, as evidenced by quantitative evaluation metrics tests conducted on four benchmark datasets. Furthermore, our WFDN excels in reconstructing images with richer detailed textures, more realistic lines, and clearer structures, affirming its exceptional superiority and robustness.
Validation of Citizen Science Meteorological Data: Can They Be Considered a Valid Help in Weather Understanding and Community Engagement?
Authors: Loglisci Nicola , Milelli Massimo , Iurato Juri , Galia Timoteo , Galizia Antonella , Parodi Antonio
Published: July 2024

Citizen science has emerged as a potent approach for environmental monitoring, leveraging the collective efforts of volunteers to gather data at unprecedented scales. Within the framework of the I-CHANGE project, MeteoTracker, a citizen science initiative, was employed to collect meteorological measurements. Through MeteoTracker, volunteers contributed to a comprehensive dataset, enabling insights into local weather patterns and trends. This paper presents the analysis and the results of the validation of such observations against the official Italian civil protection in situ weather network, demonstrating the effectiveness of citizen science in generating valuable environmental data. The work discusses the methodology employed, including data collection and statistical analysis techniques, i.e., time-series analysis, spatial and temporal interpolation, and correlation analysis. The overall analysis highlights the high quality and reliability of citizen-generated data as well as the strengths of the MeteoTracker platform. Furthermore, our findings underscore the potential of citizen science to augment traditional monitoring efforts, inform decision-making processes in environmental research and management, and improve the social awareness about environmental and climate issues.
Nanoimprinted Plasmonic Crystals for Cost-Effective SERS Identification of Methylated DNAs
Authors: Kawasaki Daiki , Nishitsuji Ryosuke , Endo Tatsuro
Published: July 2024

The development of a cost-effective and rapid assay technique for the identification of DNA methylation is one of the most crucial issues in the field of biomedical diagnosis because DNA methylation plays key roles in human health. The plasmonic crystal-based surface-enhanced Raman spectroscopy (SERS) technique is promising for the realization of such an assay method owing to its capability of generating uniformly enhanced electric fields to achieve high reproducibility and accuracy in SERS assays. However, the time and technical costs of fabricating plasmonic crystals are high, owing to the need for nanofabrication equipment. In this study, we developed nanoimprinted plasmonic crystals for cost-effective and rapid DNA methylation assays. Our plasmonic crystals identified methylated DNA with the 40-base pair adenomatous polyposis coli (APC) gene sequence, which is correlated with cell growth and cancer cells.
Organic Thermoelectric Materials for Wearable Electronic Devices
Authors: Xiao Runfeng , Zhou Xiaoyan , Zhang Chan , Liu Xi , Han Shaobo , Che Canyan
Published: July 2024

Wearable electronic devices have emerged as a pivotal technology in healthcare and artificial intelligence robots. Among the materials that are employed in wearable electronic devices, organic thermoelectric materials possess great application potential due to their advantages such as flexibility, easy processing ability, no working noise, being self-powered, applicable in a wide range of scenarios, etc. However, compared with classic conductive materials and inorganic thermoelectric materials, the research on organic thermoelectric materials is still insufficient. In order to improve our understanding of the potential of organic thermoelectric materials in wearable electronic devices, this paper reviews the types of organic thermoelectric materials and composites, their assembly strategies, and their potential applications in wearable electronic devices. This review aims to guide new researchers and offer strategic insights into wearable electronic device development.
Hydroelectric Plant Safety: Real-Time Monitoring Utilizing Fiber-Optic Sensors
Authors: Faraco Renato Luiz , Barino Felipe , Campos Deivid , Sampaio Guilherme , Honório Leonardo , Marcato André , Bessa dos Santos Alexandre , dos Santos Clayton Cesar , Hamaji Fernando
Published: July 2024

In the context of hydroelectric plants, this article emphasizes the imperative of robust monitoring strategies. The utilization of fiber-optic sensors (FOSs) emerges as a promising approach due to their efficient optical transmission, minimal signal attenuation, and resistance to electromagnetic interference. These optical sensors have demonstrated success in diverse structures, including bridges and nuclear plants, especially in challenging environments. This article culminates with the depiction of the development of an array of sensors featuring Fiber Bragg Gratings (FBGs). This array is designed to measure deformation and temperature in protective grids surrounding the turbines at the Santo Antônio Hydroelectric Plant. Implemented in a real-world scenario, the device identifies deformation peaks, indicative of water flow obstructions, thereby contributing significantly to the safety and operational efficiency of the plant.
IRBEVF-Q: Optimization of Image–Radar Fusion Algorithm Based on Bird’s Eye View Features
Authors: Cai Ganlin , Chen Feng , Guo Ente
Published: July 2024

In autonomous driving, the fusion of multiple sensors is considered essential to improve the accuracy and safety of 3D object detection. Currently, a fusion scheme combining low-cost cameras with highly robust radars can counteract the performance degradation caused by harsh environments. In this paper, we propose the IRBEVF-Q model, which mainly consists of BEV (Bird’s Eye View) fusion coding module and an object decoder module.The BEV fusion coding module solves the problem of unified representation of different modal information by fusing the image and radar features through 3D spatial reference points as a medium. The query in the object decoder, as a core component, plays an important role in detection. In this paper, Heat Map-Guided Query Initialization (HGQI) and Dynamic Position Encoding (DPE) are proposed in query construction to increase the a priori information of the query. The Auxiliary Noise Query (ANQ) then helps to stabilize the matching. The experimental results demonstrate that the proposed fusion model IRBEVF-Q achieves an NDS of 0.575 and a mAP of 0.476 on the nuScenes test set. Compared to recent state-of-the-art methods, our model shows significant advantages, thus indicating that our approach contributes to improving detection accuracy.
Analyzing Key Factors on Training Days within a Standard Microcycle for Young Sub-Elite Football Players: A Principal Component Approach
Authors: Teixeira José Eduardo , Branquinho Luís , Ferraz Ricardo , Morgans Ryland , Encarnação Samuel , Ribeiro Joana , Afonso Pedro , Ruzmetov Nemat , Barbosa Tiago M. , Monteiro António M. , Forte Pedro
Published: July 2024

Utilizing techniques for reducing multivariate data is essential for comprehensively understanding the variations and relationships within both biomechanical and physiological datasets in the context of youth football training. Therefore, the objective of this study was to identify the primary factors influencing training sessions within a standard microcycle among young sub-elite football players. A total of 60 male Portuguese youth sub-elite footballers (15.19 ± 1.75 years) were continuous monitored across six weeks during the 2019–2020 in-season, comprising the training days from match day minus (MD-) 3, MD-2, and MD-1. The weekly training load was collected by an 18 Hz global positioning system (GPS), 1 Hz heart rate (HR) monitors, the perceived exertion (RPE) and the total quality recovery (TQR). A principal component approach (PCA) coupled with a Monte Carlo parallel analysis was applied to the training datasets. The training datasets were condensed into three to five principal components, explaining between 37.0% and 83.5% of the explained variance (proportion and cumulative) according to the training day (p < 0.001). Notably, the eigenvalue for this study ranged from 1.20% to 5.21% within the overall training data. The PCA analysis of the standard microcycle in youth sub-elite football identified that, across MD-3, MD-2, and MD-1, the first was dominated by the covered distances and sprinting variables, while the second component focused on HR measures and training impulse (TRIMP). For the weekly microcycle, the first component continued to emphasize distance and intensity variables, with the ACC and DEC being particularly influential, whereas the second and subsequent components included HR measures and perceived exertion. On the three training days analyzed, the first component primarily consisted of variables related to the distance covered, running speed, high metabolic load, sprinting, dynamic stress load, accelerations, and decelerations. The high intensity demands have a high relative weight throughout the standard microcycle, which means that the training load needs to be carefully monitored and managed.
Immunogenicity of a Rotavirus VP8* Multivalent Subunit Vaccine in Mice
Authors: Cárcamo-Calvo Roberto , Boscá-Sánchez Irene , López-Navarro Sergi , Navarro-Lleó Noemi , Peña-Gil Nazaret , Santiso-Bellón Cristina , Buesa Javier , Gozalbo-Rovira Roberto , Rodríguez-Díaz Jesús
Published: July 2024

Rotavirus remains a significant public health threat, especially in low-income countries, where it is the leading cause of severe acute childhood gastroenteritis, contributing to over 128,500 deaths annually. Although the introduction of the Rotarix and RotaTeq vaccines in 2006 marked a milestone in reducing mortality rates, approximately 83,158 preventable deaths persisted, showing ongoing challenges in vaccine accessibility and effectiveness. To address these issues, a novel subcutaneous vaccine formulation targeting multiple rotavirus genotypes has been developed. This vaccine consists of nine VP8* proteins from nine distinct rotavirus genotypes and sub-genotypes (P[4], P[6], P[8]LI, P[8]LIII, P[8]LIV, P[9], P[11], P[14], and P[25]) expressed in E. coli. Two groups of mice were immunized either with a single immunogen, the VP8* from the rotavirus Wa strain (P[8]LI), or with the nonavalent formulation. Preliminary results from mouse immunization studies showed promising outcomes, eliciting antibody responses against six of the nine immunogens. Notably, significantly higher antibody titers against VP8* P[8]LI were observed in the group immunized with the nonavalent vaccine compared to mice specifically immunized against this genotype alone. Overall, the development of parenteral vaccines targeting multiple rotavirus genotypes represents a promising strategy in mitigating the global burden of rotavirus-related morbidity and mortality, offering new avenues for disease prevention and control.
Oncolytic Viral Therapy in Osteosarcoma
Authors: Karadimas Thomas , Huynh Thien Huong , Chose Chloe , Zervoudakis Guston , Clampitt Bryan , Lapp Sean , Joyce David , Letson George Douglas , Metts Jonathan , Binitie Odion , Mullinax John E. , Lazarides Alexander
Published: July 2024

Primary bone malignancies, including osteosarcoma (OS), are rare but aggressive. Current OS treatment, involving surgical resection and chemotherapy, has improved survival for non-metastatic cases but remains ineffective for recurrent or metastatic OS. Oncolytic viral therapy (OVT) is a promising alternative, using naturally occurring or genetically modified viruses to selectively target and lyse cancer cells and induce a robust immune response against remaining OS cells. Various oncolytic viruses (OVs), such as adenovirus, herpes simplex virus, and measles virus, have demonstrated efficacy in preclinical OS models. Combining OVT with other therapeutics, such as chemotherapy or immunotherapy, may further improve outcomes. Despite these advances, challenges in reliability of preclinical models, safety, delivery, and immune response must be addressed to optimize OVT for clinical use. Future research should focus on refining delivery methods, exploring combination treatments, and clinical trials to ensure OVT’s efficacy and safety for OS. Overall, OVT represents a novel approach with the potential to drastically improve survival outcomes for patients with OS.
Potential Role of APOBEC3 Family Proteins in SARS-CoV-2 Replication
Authors: Begum MST Monira , Bokani Ayub , Rajib Samiul Alam , Soleimanpour Mohadeseh , Maeda Yosuke , Yoshimura Kazuhisa , Satou Yorifumi , Ebrahimi Diako , Ikeda Terumasa
Published: July 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has acquired multiple mutations since its emergence. Analyses of the SARS-CoV-2 genomes from infected patients exhibit a bias toward C-to-U mutations, which are suggested to be caused by the apolipoprotein B mRNA editing enzyme polypeptide-like 3 (APOBEC3, A3) cytosine deaminase proteins. However, the role of A3 enzymes in SARS-CoV-2 replication remains unclear. To address this question, we investigated the effect of A3 family proteins on SARS-CoV-2 replication in the myeloid leukemia cell line THP-1 lacking A3A to A3G genes. The Wuhan, BA.1, and BA.5 variants had comparable viral replication in parent and A3A-to-A3G-null THP-1 cells stably expressing angiotensin-converting enzyme 2 (ACE2) protein. On the other hand, the replication and infectivity of these variants were abolished in A3A-to-A3G-null THP-1-ACE2 cells in a series of passage experiments over 20 days. In contrast to previous reports, we observed no evidence of A3-induced SARS-CoV-2 mutagenesis in the passage experiments. Furthermore, our analysis of a large number of publicly available SARS-CoV-2 genomes did not reveal conclusive evidence for A3-induced mutagenesis. Our studies suggest that A3 family proteins can positively contribute to SARS-CoV-2 replication; however, this effect is deaminase-independent.
Unveiling the Significance of LysE in Survival and Virulence of Mycobacterium tuberculosis: A Review Reveals It as a Potential Drug Target, Diagnostic Marker, and a Vaccine Candidate
Authors: Upadhyay Shilpa , Dhok Archana , Kashikar Supriya , Quazi Zahiruddin Syed , Agarkar Vinod B.
Published: July 2024

Tuberculosis (TB) remains a global health threat, necessitating innovative strategies for control and prevention. This comprehensive review explores the Mycobacterium tuberculosis Lysine Exporter (LysE) gene, unveiling its multifaceted roles and potential uses in controlling and preventing tuberculosis (TB). As a pivotal player in eliminating excess L-lysine and L-arginine, LysE contributes to the survival and virulence of M. tuberculosis. This review synthesizes findings from different electronic databases and includes 13 studies focused on the LysE of M. tuberculosis. The research unveils that LysE can be a potential drug target, a diagnostic marker for TB, and a promising candidate for vaccine development. The absence of LysE in the widely used BCG vaccine underscores its uniqueness and positions it as a novel area for TB prevention. In conclusion, this review underscores the significance of LysE in TB pathogenesis and its potential as a drug target, diagnostic marker, and vaccine candidate. The multifaceted nature of LysE positions it at the forefront of innovative approaches to combat TB, calling for sustained research efforts to harness its full potential in the global fight against this infectious disease.
Género y humanidades en la mirada historiográfica de Joan Scott
Authors: Videla Hernan
Published: July 2024

Este articulo refleja los resultados obtenidos luego de la práctica de una investigación social que se concentró académicamente en el discurso feminista de la historiadora contemporánea Joan W. Scott. Este alcance pudo ser efectivo partir del estudio de naturaleza historiográfica operado en función de sus principales textos científicos. El diseño metodológico empleado responde al diseño cualitativo de las Ciencias Sociales, con énfasis en los recursos historiográficos a través de la implementación de la técnica documental. En su desarrollo se descubrió un conjunto particular de contribuciones teóricas del orden humanístico, político y territorial que permiten asociarlo a las líneas epistemológicas criticas posestructuralistas paralelas a las diferentes instancias de producción generizada la autora.
Resistir y persistir: la dimensión de la persistencia en la acción colectiva
Authors: Roldán Macarena
Published: July 2024

El propósito del trabajo es examinar la dimensión de la persistencia como categoría analítica de la acción colectiva. Para ello, se presentan los resultados de una tesis de doctorado en la que se abordaron los procesos de subjetivación política de jóvenes que organizan y sostienen –desde hace más de quince años– movilizaciones populares frente a la violencia policial en Córdoba, Argentina. La acción colectiva estudiada fue la llamada Marcha de la Gorra, sobre la que se realizó un trabajo etnográfico con una perspectiva psicosocial. Además de la elaboración de notas de campo, se realizaron entrevistas en profundidad y entrevistas breves, denominadas conversaciones en marcha. En estas instancias participaron más de sesenta jóvenes activistas. A partir de la producción de datos y análisis de manera sostenida, la dimensión de la persistencia de la Marcha fue cobrando significatividad analítica. Tras ocho años de duración, el estudio longitudinal permitió considerar el valor cualitativo de la persistencia de la acción colectiva y su implicancia en la subjetividad de las y los jóvenes. Asimismo, se mostró como una dimensión clave en el establecimiento de conexiones entre la acción en el espacio público y sus territorios cotidianos.
La intervención social en personas con situaciones vulnerables
Authors: Barahona Martínez Dr. hc Gipson Emilio , León Salazar Viviana Lizbeth , Barzola Plúas Yorly Geomar
Published: July 2024

En resumen, las intervenciones sociales en poblaciones vulnerables pueden mejorar
significativamente su calidad de vida, proporcionar un mayor acceso a los recursos y generar
beneficios a largo plazo y resultados sostenibles. Estas intervenciones pueden ayudar a las
personas a superar situaciones de dependencia y limitación, y a mejorar su capacidad de
autodeterminación y toma de decisiones. Además, las intervenciones sociales sostenibles pueden
generar cambios duraderos y mejorar la calidad de vida de las personas vulnerables a largo plazo.
Como el alcance de la investigación es descriptivo, este permite un análisis profundo y minucioso
de los problemas, la conducta de las variables estudiadas. El alcance de la investigación permitió
determinar el impacto que tiene las intervenciones sociales en personas con situaciones
vulnerables, las cuales con su accionar buscan mejorar la calidad de vida de quienes más lo
necesitan. El presente proyecto de investigación aborda un enfoque mixto. El enfoque de la
investigación cualitativa es un método de observación que busca comprender el comportamiento
humano y sus significados subjetivos e intersubjetivos. Se utiliza para responder a preguntas como
por qué y cómo la gente toma determinadas decisiones, apoyado con el enfoque cuantitativo que
busca ver la interacción y la variación de las variables de estudio. En conclusión, la intervención
social juega un papel crucial para mejorar la vida de las poblaciones vulnerables. Al identificar
estas poblaciones y comprender sus necesidades y desafíos, se pueden implementar
intervenciones sociales específicas para brindar asistencia financiera, atención médica, educación
y oportunidades de empleo.
Optimizando el aprendizaje colaborativo intercultural bilingüe mediado por las Tics: Caso Universidad Estatal de Bolívar.
Authors: Fuentes Seisdedos Liana , Cárdenas Benavides Jonathan Patricio , Chávez Benavides Raúl Marcelo
Published: July 2024

El artículo científico destaca la importancia de cerrar la brecha digital y promover la inclusión digital en contextos interculturales y bilingües. Se resalta la percepción positiva hacia las Tecnologías de la Información y Comunicación (TIC), herramientas colaborativas y metodologías interactivas en el proceso de enseñanza-aprendizaje, respaldando así la implementación de estrategias educativas basadas en TIC. Además, se enfatiza la necesidad de formar a los estudiantes en competencias digitales para enfrentar los desafíos actuales en entornos profesionales, subrayando la importancia de desarrollar capacidades, habilidades y destrezas para adaptarse a los diversos entornos corporativos y profesionales actuales. La investigación también aborda la resistencia al uso de la tecnología en algunas comunidades, atribuida a factores culturales. En resumen, el artículo subraya la importancia de cerrar la brecha digital, promover la inclusión digital y formar en competencias digitales para garantizar una educación equitativa y de calidad en contextos interculturales y bilingües.
Insight into the genetic diversity of Selle Français horse populations based on whole D-loop sequencing of mitochondrial DNA
Authors: Ropka-Molik Katarzyna , Ayad Abdelhanine , Musiał Adriana D. , Besseboua Omar , Aissanou Sofiane , Stefaniuk-Szmukier Monika , Piórkowska Katarzyna
Published: July 2024

The Selle Français (SF) breed originated from native France horses crossed with Thoroughbreds, Arabs, Anglo-Arabs and French Trotters, which allowed for individuals to be obtained with excellent predispositions and a versatile usage for equestrian sports. The performance of the
SF horse is widely accepted in the fields of show jumping and eventing; however, they have successfully started to compete in other areas such as dressage, vaulting, carriage driving and TREC competitions. To date, information about the genetic structure of the SF breed has been very limited.
In the present report, Sanger sequencing was applied to analyse the whole D-loop of mitochondrial DNA of 98 samples representing Selle Français horses originating from two populations: Algerian (n=47) and French (n=51). The result obtained showed the presence of 19 SNPs,
which allowed us to divide the samples into 41 haplotypes (OR909723‐OR909773). A higher number of haplotypes was detected in the Algerian population (n=24) compared to the French population (n=14), but both populations did not represent unique clusters and showed a high
degree of genetic similarities. The result showed that the identified haplotypes of the SF belonged to four clades: L, A, B and G. The present report gives strong evidence that the Selle Français breed has been established based on a great influence of the Thoroughbred, whose close
connection is more visible in the French population. The haplogroup assignment to L clades proved that the SF breed has European origin as ancestral haplogroup L was assigned to West and South Europe while A to West Asia and G and B to Middle East. Our results show SF as an example of a contemporary
breed of sport horses with European roots further influenced by local breeds.
A saúde mental dos que cuidam: os principais desafios para os profissionais da saúde
Authors: Pessoa Amanda Stival , Firmino Isabella Reile , Silva Fernanda Oliveira , Soares Isabella Nepomuceno , Romão Anna Glaucia Rodrigues , Costa Carolinny Moreira , Amorim Tiago Fontes de , Peixoto Maryangela Melo
Published: July 2024

O presente artigo teve como objetivo discutir sobre o adoecimento mental vivenciado por profissionais da saúde e compreender os desafios e estratégias que podem auxiliar em uma melhora da qualidade de vida. Após a análise dos dados, foi possível constatar que as condições de trabalho e a rotina laboral têm interferido diretamente na saúde do cuidador, levando a um aumento de quadros de ansiedade, depressão e estresse pós-traumático. Portanto, torna-se necessário a implementação de medidas de prevenção para mitigar a problemática do sofrimento do trabalhador.
Gestão de ativos – manutenção preventiva de ferramentais por utilização
Authors: Lima Alessandro Assis de , Silva Leandro Cardoso da
Published: July 2024

Este estudo aborda a implementação de um sistema de gestão otimizada de manutenção preventiva para ferramentais, visando maximizar a eficiência operacional e prolongar a vida útil dos equipamentos. O objetivo principal foi desenvolver e aplicar estratégias de manutenção baseadas no uso efetivo e nas condições reais dos ativos. A metodologia empregada combinou técnicas analíticas avançadas e monitoramento de condições para prever e prevenir falhas antes que causassem paradas inesperadas. Os resultados demonstraram uma redução significativa nos custos de manutenção e aumento na disponibilidade dos equipamentos, corroborando a eficácia da abordagem proposta. Este estudo não só reforça a importância da manutenção preventiva como também estabelece um precedente para futuras pesquisas voltadas para a otimização contínua dos processos de manutenção.
Dermatofibrosarcoma Protuberans em vulva com múltiplas recidivas: à propósito de caso
Authors: Cassino Cristiana Pittella , Ribeiro Vitor Ramos de Araújo , Pinheiro Sarah Mezadri , Chambô Filho Antônio
Published: July 2024

Introdução: O Dermatofibrosarcoma Protuberans (DFSP) é uma forma rara de neoplasia cutânea, com ocorrência em qualquer parte do corpo. Pode acometer a região genital, como a vulva, embora seja um sítio incomum da patologia. Embora rara, a DFSP tem importância clínica devido a sua propensão à recorrência local e sua alta taxa de invasão neoplásica. Recorrências locais são comuns, mesmo após a cirurgia com margens aparentemente livres de doença. O tratamento padrão para o DFSP é a excisão cirúrgica completa com margens amplas, a fim de minimizar o risco de recorrência. Relato de caso: Mulher, 56 anos, G2PC2, em 2006, notou o surgimento de uma nodulação vulvar em grande lábio a direita. Lesão não pruriginosa, indolor a palpação, de base fixa, com aproximadamente 1,5 cm. Biópsia da lesão compatível com fibrohistiocitoma de pele. Aproximadamente quatro anos após a primeira biópsia, houve o surgimento de nova nodulação de mesma característica, no mesmo local, com crescimento progressivo e resultado de biópsia com mesma descrição. Em janeiro de 2012, foi realizada uma vulvectomia. Biópsia pós cirúrgica resultou em um DFSP de vulva. Após dois anos, surgiu nova lesão recidivada em monte pubiano novamente com o resultado histopatológico compatível com DFSP. Em 2020, nova recidiva em topografia de vulva, realizada nova abordagem e solicitada revisão da primeira lâmina e imuno-histoquímica da amostra, que concluiu DFSP acometendo tecido adiposo subcutâneo e imuno-histoquímica com positividade para CD34. Discussão: Mesmo sendo uma neoplasia cutânea de crescimento lento, a característica mais prevalente do DFSP é o grande potencial invasivo, o que resultou em seriadas tentativas cirúrgicas locais na paciente. A decisão de realizar uma vulvectomia como abordagem cirúrgica para o DFSP é discutível. No caso descrito, a decisão cirúrgica foi escolhida dada a raridade da neoplasia, seu sítio incomum e a baixa resposta às terapias medicamentosas e radioterápicas. O diagnóstico preciso do DFSP é essencial para garantir uma abordagem terapêutica adequada. Conclusão: Este tipo de neoplasia cutânea, embora raro, demonstra uma propensão à recorrência, mesmo após intervenções terapêuticas agressivas, como ressecções cirúrgicas extensas. O caso relatado destaca a importância da suspeita clínica e da avaliação histopatológica criteriosa na abordagem de lesões cutâneas incomuns. O DFSP deve ser considerado em pacientes com histórico de recidivas ou crescimento progressivo de lesões cutâneas aparentemente benignas.
Fatores envolvidos na infecção de derivação ventriculoperitoneal: uma revisão integrativa
Authors: Ferreira Tainan Gomes , Santiago Melina Pereira Lima , Lusvarghi Enzo Fabrizzio Moretto , Ferreira Vinícius Bacelar , Miñarro Ana Luiza Mauro , Ferreira Victor Alexandre de Lima , Simão Murilo Marques , Azevedo Luiz Fernando Menezes Soares de , Pereira Felipe Salvagni , Pinheiro Caroline Dourado , Brandão Raysson dos Santos , Saraiva Jose Eduardo Carvalho , Vieira Mikael Veras
Published: July 2024

Introdução: A derivação ventriculoperitoneal (DVP) é o método mais utilizado para o tratamento de hidrocefalia, entretanto, pode implicar em uma série de consequências, sendo a infecção a mais comum e menos desejada, estando associada a uma taxa significativa de morbimortalidade. Na literatura discute-se os possíveis fatores envolvidos na infecção da DVP. Objetivos: Avaliar os fatores envolvidos na infecção de DVP e a existência de fatores de risco associados. Metodologia: Trata-se de uma revisão integrativa na base de dados PUBMED utilizando os descritores “INFECTION AND VENTRICULOPERITONEAL SHUNT’’ para artigos publicados entre 2019 e 2024. Resultados: A DVP é um procedimento cirúrgico muito utilizado frente a anomalias congênitas (40,5%), hidrocefalia obstrutiva (20%) e outra manifestações como AVC, tumores e meningites. Contudo, o procedimento pode culminar em diferentes complicações como infecção e mau funcionamento do shunt. Estudos retrospectivos mostram que a variação da prevalência da infecção pós DVP pode variar de 1 até 20%, a grande variação leva inúmeros pesquisadores a buscarem entender se a equipe e o ambiente cirúrgico podem estar envolvidos. Medidas protocolares empregadas a fim de diminuir as taxas de infecção são extremamente significativas, modificando as taxas de forma positiva após suas implantações 8,8-5,6% e 3,5-1,9%. Conclusão: A DVP é o procedimento mais comum da neurocirurgia pediátrica, tendo a infecção como sua complicação mais comum, a febre é o sinal clínico mais encontrado, seguido de vômitos e alterações inflamatórias. Medidas como limitar o tempo operatório e limitar o pessoal da sala de cirurgia demonstraram ser eficazes na prevenção contra infecção.
A Study on the Service Standardization Strategy Using AHP and IPA
Authors: Yun Jaeseok , Kim Sungyeon , Han Seonghyeon , Kim Jinmin , Koo Sanghoi ,   Society for Standards, Certification and Safety
Published: July 2024

The service industry is undergoing changes such as digital transformation, and it is expected that the number of employees in all types of service industries will increase in the future. Therefore, service certification and standardization is essential to secure the competitiveness of the domestic service industry along with the leap to high-value-added industries. Existing research has focused on certification and standardization strategies to revitalize specific service sectors, but there is a lack of research on the service industry as a whole. Therefore, this study aims to develop the importance and priority of domestic service standardization strategies using AHP and IPA analysis to secure the competitiveness of the domestic service industry. Prior to the analysis, we first reviewed service standards, the current status of the domestic service industry, the current status of domestic service standards, and the current status of international service standards. Through the literature study, three large categories (pure service standards, service delivery infrastructure standardization, and service-applicable management service standardization) and eight medium categories (logistics and distribution, finance, safety, basic IT, education, telecommunications, tourism, and environment) were identified for AHP analysis. The analysis result of the 100 core service standards strategy showed that the development of standards in the fields of ‘social safety services’ and ‘promising services’ was evaluated as a high priority. The AHP analysis shows that ‘safety’ is the most important and urgent among ‘service delivery infrastructure standardization’, reflecting that safety is a top consideration in the service industry, suggesting that safety-related standards should be given top priority when establishing service standardization strategies. This study is expected to be used as a basis for the development of the domestic service industry and the development of certification by suggesting priorities for policies that reflect the problems of the domestic service industry, changes in the service industry, and prospects for the service industry, and to derive service strategies.
Taxonomic Revision of the Petiolatum Clade of Elaphoglossum sect. Lepidoglossa (Dryopteridaceae)
Authors: Martínez-Becerril Ana Gabriela , Vasco Alejandra
Published: July 2024

This paper provides a monograph of the petiolatum clade of Elaphoglossum Schott ex J. Sm. sect. Lepidoglossa Christ (Dryopteridaceae). This group has been recovered as monophyletic in several molecular phylogenetic analyses. Morphologically, the petiolatum clade is recognized by laminae with resinous dots and flat and/or stellate scales, rhizome scales with acute to filiform-tortuous apices, scales on the proximal portion of the petiole with dark apices, and perines broadly folded, sparsely echinulate with spines less than 1 μm high, or (in E. petiolatum (Sw.) Urb.) with sparse irregular microstructures. Eight species are recognized as a part of the clade, all of them distributed in the American tropics from Mexico to Panama, and one species in the Greater Antilles. Most of the species occur between 1000 and 2500 m elevation in tropical, temperate, and pine-oak forests. Presented here are an identification key, a full synonymy, detailed descriptions, a list of specimens examined, an index to collectors’ names and collection numbers, images of the plants and their main structures, spore microphotographs, and distribution maps for all species. A new combination is made for E. schmitzii (Mett. ex Kuhn) Martínez-Bec. & A. Vasco, and lectotypes are designated for Acrostichum intermedium Fée, E. muelleri (E. Fourn.) C. Chr., E. potosianum Christ, E. pringlei (Davenp.) C. Chr., and E. schmitzii.
Social Development of South Indian Tribes
Authors: S Anandakumar , G Ramakrishnan
Published: July 2024

What tribes are they? Understanding the nature of man will help you find the solution to this query. Primitive man, a breed of creatures that grew and changed over thousands of years, was destined to kill or perish. His means of defence and sustenance became hunting. He hunted and preyed on other creatures naturally. When there was no hunting, those of us who had always considered ourselves to be strict vegetarians would only eat fruits and tubers from the forest to survive. It was feasible to catch animals alive and feed them when needed (as in the case of the Sami, rearing and butchering the kida) because to the expertise and training acquired through constant hunting. He is now a food producer, having risen from the state of gathering and consuming what is available to him from nature. He's now consuming dairy, cereals, and pulses in addition to meat. Initially viewed as livestock and food sources, he started to consider animals as tools for agriculture. Towns and cities were created when forests were cleared and agriculture was established in the riverbeds that were rich in water. There is no longer a need for the group power needed for hunting. Those who worked in groups broke up into families at this time, cattle and land became private property, and the first structures of a state that looked out for the community emerged. He is now a food producer, having risen from the state of gathering and consuming what is available to him from nature. He's now consuming dairy, cereals, and pulses in addition to meat. Initially viewed as livestock and food sources, he started to consider animals as tools for agriculture. Towns and cities were created when forests were cleared and agriculture was established in the riverbeds that were rich in water. There is no longer a need for the group power needed for hunting. Those who worked in groups broke up into families at this time, cattle and land became private property, and the first structures of a state that looked out for the community emerged. It is not required to believe that these developments occurred globally at the same time. It should be mentioned that commonalities may have led to a variety of specific and general disparities. Different segments of the population have fallen behind at different points over the lengthy transition from hunting to modern technologies. The ethnic groups left behind continue to practise what humans originally knew for food, clothing, shelter, worship, beliefs, and interpersonal relationships because they are unable to adapt to the inevitable, never-ending march of change. Tribes are ethnic communities who adhere to the lifestyle of prehistoric man, who lived in harmony with nature and did not significantly alter it. They do not associate with the bulk of humanity, who dominate or destroy nature in order to meet their demands.
Multiple System Atrophy: Modern Concepts, Own Clinical Observation
Authors: Павловская Т.С. , Рушкевич Ю.Н. , Гвищ Т.Г. , Клюнчик С.Г. , Свинковская Т.В. , Мальгина Е.В. , Стреха М.А.
Published: July 2024

Мультисистемная атрофия представляет собой тяжелое медленно прогрессирующее нейродегенеративное заболевание, которое характеризуется сочетанием выраженной вегетативной недостаточности и различных двигательных нарушений, включая синдром паркинсонизма и/или мозжечковую дисфункцию в качестве ключевых симптомов, а также признаки поражения пирамидной системы и др. В настоящее время выделяют 2 основных фенотипа заболевания: паркинсонический и мозжечковый, в зависимости от преимущественной локализации пораженных структур центральной нервной системы и превалирующей клинической симптоматики. Для диагностики мультисистемной атрофии должны использоваться критерии, принятые Международным обществом по изучению болезни Паркинсона и двигательных расстройств в 2022 г. До настоящего времени не разработано методов этиотропной и патогенетической терапии данного заболевания. Симптоматическая терапия включает медикаментозную коррекцию ортостатической гипотензии, урологических нарушений, запоров, проявлений акинетико-ригидного синдрома и др. Описано собственное клиническое наблюдение этой редкой патологии, особенностью которого являются ранний дебют заболевания и отсутствие типичных нейровизуализационных маркеров при проведении МРТ головного мозга на развернутой стадии болезни.

Multisystem atrophy is a severe slowly progressive neurodegenerative disease characterized by a combination of severe autonomic insufficiency and various movement disorders, including Parkinsonism syndrome and/or cerebellar dysfunction as a key symptom, as well as signs of damage to the pyramidal system, etc. Currently, there are two main phenotypes of the disease: parkinsonian and cerebellar, depending on the predominant localization of the affected structures of the central nervous system and the prevailing clinical symptoms. The criteria adopted by the International Parkinson and Movement Disorder Society in 2022 should be used to diagnose multisystem atrophy. To date, no methods of etiotropic and pathogenetic therapy of multisystem atrophy have been developed. Symptomatic therapy includes drug correction of orthostatic hypotension, urological disorders, constipation, manifestations of akinetic-rigid syndrome, etc. The author describes his own clinical observation of this rare pathology, the feature of which is the early onset of the disease and the absence of typical neuroimaging markers during MRI of the brain at the advanced stage of the disease.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PERNIKAHAN USIA DINI DI WILAYAH PUSKESMAS TUMBANG JUTUH
Authors: Karolina Yunike , Friscila Ika , Hidayah Nur , Lathifah Nur
Published: July 2024

Fenomena pernikahan usia dini menjadi salah satu masalah yang cukup pelik yang berkembang di negara maju maupun negara berkembang, khususnya Indonesia. Pendidikan, pengetahuan dan lingkungan sosial budaya masyarakat menjadi faktor dominan untuk melakukan pernikahan usia dini. Melakukan analisis tentang faktor yang berhubungan dengan pernikahan usia dini pada remaja putri di wilayah kerja Puskesmas Tumbang Jutuh. Penelitian ini adalah data deskriptif koleratif dengan pendekatan cross sectional study. Sampel adalah 55 remaja putri dengan rentang usia 15 -20 tahun di wilayah kerja Puskesmas Tumbang Jutuh. Instrumen menggunakan kuesioner yang dianalisis menggunakan chi square. Hasil penelitian adalah Variabel pernikahan usia dini adalah kategori yang menikah di usia dini sebanyak 31 orang atau 56,4%, analisis statistik faktor pendidikan (p value 0,000 ), pengetahuan (p value 0,001), lingkungan sosial (p value 0,000) yang bermakna ketiga faktor ini memiliki hubungan dengan pernikahan usia dini pada remaja putri. Faktor pendidikan, pengetahuan dan lingkungan sosial berhubungan terhadap kejadian pernikahan usia dini pada remaja putri.
Kata kunci: Lingkungan Sosial, Pendidikan, Pengetahuan, Pernikahan Usia Dini, Remaja Putri
Faktor yang berhubungan dengan upaya preventif Kesehatan Kerja terhadap bahaya debu padat pada proses penggilingan kaleng bekas menjadi biji besi di PT. SAL
Authors: Makomulamin  , Puspita Sari Nila , Elsa Ghozali Adinda , Wardani Sri
Published: July 2024

https://docs.google.com/document/d/1Z1aDJd4O3O1WSU20k76mSf0eQo6RAShp/edit?usp=sharing&ouid=101000294218448414922&rtpof=true&sd=true
CHARACTERIZATION OF THE CHLOROPLAST GENOME OF AQUILARIA CRASSNA PIERRE EX LECOMTE DISTRIBUTED IN VIETNAM USING LONG-READ DATA (OXFORD NANOPORE TECHNOLOGIES)
Authors: Nguyen Nam Nhat , Do Khoa Hoang Dang
Published: July 2024

Aquilaria crassna Pierre ex Lecomte is a critically endangered species that is famous for its fragrance compounds for perfume and incense production. In this study, the complete chloroplast genome of A. crassna was sequenced using a long-read sequencing method of Oxford Nanopore Technologies. The complete chloroplast genome of A. crassna was 174,766 bp in length, which comprised a large single copy region of 87,231 bp, a small single copy region of 3,343 bp, and two inverted repeat regions of 42,096 bp. This genome contained 95 protein-coding genes, 38 transfer RNA genes, and eight ribosomal RNA genes. The analysis ofsmall single repeats revealed 39 mononucleotide and seven dinucleotide repeats, which are located mainly in non-coding regions. Comparative genomic analysis exhibited high conservation of the chloroplast genome within the Aquilaria genus regarding gene content, gene order, and genomic structure. This study provides useful genomic data for further studies examining the genetic population, genetic conservation, molecular markers, and phylogeny of Aquilaria crassna and related species within Thymelaeaceae.
-- PDF Article: https://drive.google.com/file/d/16MoCLRJqgLJ61N9S3yG6uOyHrJeVMeur/view?usp=sharing
Rancang Bangun Aplikasi Pembuatan Web Video Streaming Online: Inovasi Berbasis Web untuk Pengalaman Menonton
Authors: Ardiansyah Ari , Tsabitha Putri Anjani  , Marta Anjasmara
Published: July 2024

Video streaming telah dengan cepat naik daun sebagai bentuk hiburan yang populer di era digital modern. Namun, masih ada beberapa masalah dengan platform streaming video saat ini. Beberapa masalah tersebut termasuk kualitas video yang buruk, kesulitan dalam mengelola pemutaran, dan kesulitan dalam menemukan video yang diinginkan. Tujuan utama dari penelitian ini adalah untuk merancang platform streaming video berbasis web yang menyederhanakan pengalaman pengguna, memudahkan menonton video, mencari, dan mengontrol pemutaran. Untuk melayani penggunanya dengan lebih baik, platform ini akan menggunakan teknologi encoding video untuk meningkatkan kualitas video dan algoritma pembelajaran mesin untuk merekomendasikan konten yang sesuai dengan minat mereka. Kerangka untuk streaming video akan dibangun menggunakan style sheets (CSS), HTML, dan JavaScript. Implementasi platform akan dibagi menjadi dua tahap utama: pengembangan dan pengujian. Saat ini, platform sedang dalam pengembangan, menggunakan teknologi encoding video dan pembelajaran mesin. Selama tahap pengujian, pengguna akan diminta untuk memberikan umpan balik. Hasil penelitian ini diharapkan dapat meningkatkan pengalaman streaming video secara keseluruhan bagi pengguna. Selain itu, hasil penelitian ini juga diharapkan dapat menjadi sumber daya yang berharga bagi peneliti masa depan yang mempertimbangkan pengembangan platform streaming video mereka sendiri.