bluuebunny/crossref_metadata_2025 huggingface dataset:
Energy and exergy analysis of primary steam superheating effects on the steam ejector applied in the solar renewable refrigeration cycle in the presence of spontaneous nucleation
Authors: zhang Wang Han
Published: November 2023

The generator energy consumption in the renewable refrigeration cycles is supplied by solar energy, geothermal energy and waste heat. The thermal energy of low grade can be utilized to superheat the vapour in a generator of the refrigeration cycle. The effect of primary flow superheating was examined on the renewable refrigeration cycle performance using the wet steam model in the ejector. The vapour’s degree of superheating was selected in the 0–100 K range. The superheating level effects were investigated on parameters (wet steam, entrainment ratio, energy consumption, COP, second law efficiency and exergy destruction). The aim of this study is a comprehensive evaluation of the effect of superheat on the ejector refrigeration cycle and the flow behavior in the steam ejector simultaneously. The results represented that superheating the inlet steam in the primary nozzle weakens the spontaneous condensation intensity and delays the condensation shock, the combining process between the secondary flow and the primary flow is improved, and the entrainment ratio is increased, the generator energy consumption and the efficiency of the second law are decreased, the exergy destruction in the ejector is reduced, and the total exergy destruction of the refrigeration cycle is increased. Considering the second law efficiency, COP, the entrainment ratio and the energy consumption, a temperature of 40° of the superheat was achieved as the best degree of the superheat in this cycle that in comparison to the state without superheating, the entrainment ratio and COP are increased by 4.4 % and 1 %, the second law efficiency and the generator energy consumption are reduced by 19.5 % and 1.6 %, respectively.
Potential applications of low-cost Brazilian corn starch as an adsorbent for removing the Acid Violet 19 contaminant from river water
Authors: do Rêgo Júnior Alrivan Gomes , de Oliveira Íngride Pamilly Ribeiro Araújo , de Souza Joalis Barbalho , da Fonsêca Melo Tereza Noêmia Tavares , da Silva Vieira Ricardo Alan , dos Santos Souza Ytalo Cleyton , de Souza Xavier Moizes , de Queiroz Lucas Rego , Sales Alves Jose Irlandio , de Menezes Francisco Leonardo Gomes , Júnior Francisco Franciné Maia , Khan Sabir
Published: November 2023

Indeed, the textile dye industry has a significant impact on the global economy, as it is an integral part of the textile and fashion industries. However, this advancement has become a great concern with industrial waste, a good part of these dyes have toxic characteristics to the environment and living beings. The objective of this work is the use of local corn starch as an adsorbent, for the removal of acid violet (AV19), a dye that is highly toxic and carcinogenic in real water samples. The material was characterized by scanning electron microscopy (SEM) and infrared (IR). The optimized parameters were concentration, time, and pH, in which the best results will be obtained at 60 min and pH 7. The experiment was compared to the Langmuir, Freundlich, and Temkin models. The concentration of dye was 4 mg L−1 had the highest removal which was 84.46 %. The prim rate constant isk′ = 0.8592 therefore the adsorption system studied obeys the pseudo-second-order kinetic model. In the next step, we will apply the top-performing starch to environmental samples containing the investigated dye. An analytical curve was constructed in the 2–14 ppm range at a maximum wavelength of 590 nm. The detection limit was 0.541 mg/L, and the percentage recovery was obtained in the range of 95–99.8 % for real water samples.
Preparing Basketball Players for Competition During COVID-19 Lockdown: An International Strength and Conditioning Perspective
Authors: Bird Stephen P. , Goriss Brent , DeLosAngeles Ernest , Spencer Nathan
Published: November 2023

The global outbreak of Coronavirus disease (COVID-19) resulted in governing bodies suspending professional sports leagues, including the National Basketball Association (NBA) and notably the International Olympic Committee (2020 Tokyo Olympic Games). As competitions resumed, performance staff shifted their focus to preparing athletes for a safe return to competition. This article provides novel and unique international perspectives on preparing basketball players for competition during COVID-19 lockdown outlining lessons learned from the NBA, FIBA Asia Cup, and Olympic Games. Reflections are provided unpacking central themes related to (a) the impact of COVID-19 on physiological and psychological domains; (b) strength and conditioning methods and nutritional strategies used in the (re)training process; and (c) situation-specific interventions and educational strategies related to psychological well-being. Collectively, performance staff responsible for the preparation of basketball players during COVID-19 must consider additional health and performance support to ensure physical and psychological readiness to complete without negatively impacting physical development.
Effect of Loading Frequency on the Fretting-Corrosion Degradation of the Stem-Head and Stem-Cement Interfaces in Hip Implants
Authors: dos Santos Vinícius O. , Cubillos Patricia O. , dos Santos Claudio T. , Fernandes Wellington G. , Monteiro Maurício J. , Caminha Ieda M. V. , Moré Ari D. O. , Roesler Carlos R. M.
Published: November 2023

Degradation by fretting-corrosion of the stem-head interface is considered the main source of the release of metal ions and debris, leading to adverse tissue reactions at the cemented total hip arthroplasty. The aim of this study was to investigate the effect of loading frequency on the fretting-corrosion degradation at the stem-head and stem-cement interfaces through electrochemical measurements during the benchtop testing. Different loading frequency conditions were investigated with the same number of cycles (1,000 cycles) to calculate the fretting current and Faraday mass loss. For both interfaces, there was a biphasic waveform response of the fretting current to the load applied, at 1 Hz, almost with phase opposition. An increase in the loading frequency (1 to 30 Hz) generated a higher fretting current for the stem-head (2.97 ± 2.04 μA to 7.66 ± 2.46 μA) and stem-cement (7.62 ± 2.26 μA to 25.48 ± 5.35 μA) interfaces. However, an increase in the loading frequency (1 to 30 Hz) reduced the Faraday mass loss of the stem-head (0.79 ± 0.54 μg to 0.07 ± 0.02 μg) and stem-cement (2.02 ± 0.62 μg to 0.32 ± 0.12 μg) interfaces because of a reduction in the overall testing time. Thus, there is a compromise relation between the fretting current and the Faraday mass loss, which must be considered when setting the loading frequencies in the fretting-corrosion benchtop testing of hip implants.
Socially Mediated Shift in Neural Circuits Activation Regulated by Synergistic Neuromodulatory Signaling
Authors: Clements Katie N. , Ahn Sungwoo , Park Choongseok , Heagy Faith K. , Miller Thomas H. , Kassai Miki , Issa Fadi A.
Published: November 2023

Animals exhibit context-dependent behavioral decisions that are mediated by specific motor circuits. In social species these decisions are often influenced by social status. Although social status-dependent neural plasticity of motor circuits has been investigated in vertebrates, little is known of how cellular plasticity translates into differences in motor activity. Here, we used zebrafish (Danio rerio) as a model organism to examine how social dominance influences the activation of swimming and the Mauthner-mediated startle escape behaviors. We show that the status-dependent shift in behavior patterns whereby dominants increase swimming and reduce sensitivity of startle escape while subordinates reduce their swimming and increase startle sensitivity is regulated by the synergistic interactions of dopaminergic, glycinergic, and GABAergic inputs to shift the balance of activation of the underlying motor circuits. This shift is driven by socially induced differences in expression of dopaminergic receptor type 1b (Drd1b) on glycinergic neurons and dopamine (DA) reuptake transporter (DAT). Second, we show that GABAergic input onto glycinergic neurons is strengthened in subordinates compared with dominants. Complementary neurocomputational modeling of the empirical results show that drd1b functions as molecular regulator to facilitate the shift between excitatory and inhibitory pathways. The results illustrate how reconfiguration in network dynamics serves as an adaptive strategy to cope with changes in social environment and are likely conserved and applicable to other social species.
The Legacy of Dr. Mae C. King
Authors: Wright Andrene , Crawford Claire , Lenear India
Published: November 2023

At the 2023 National Conference of Black Political Scientists (NCOBPS), Andrene Wright, Claire Crawford, and India Lenear were invited to speak about the legacy of Dr. Mae C. King at the 13th Annual NCOBPS Founder’s Symposium. Our remarks received overwhelming support from NCOBPS members, colleagues, and friends who knew Dr. King. We were invited to memorialize the moment with a piece in the National Review for Black Politics (NRBP). It’s not lost on us that the forum where we made these remarks would not exist if it weren’t for Dr. King, a founding member. To that, we say we are profoundly honored and humbled by these invitations. Below is a compilation of what we expressed at the Founders Symposium in Atlanta on March 10, 2023. We hope these reflections can provide a small fraction of the value Dr. King has gifted to the discipline, Black political scientists, and those whose lives were made better by her brilliance.
Treatment of Difficult Pancreatic Duct Strictures Using a Cystotome: A Single-Center Experience
Authors: Lee Jonghyun , Kim Dong Uk , Han Sung Yong
Published: November 2023

Background/Aim: Endoscopic retrograde cholangiopancreatography (ERCP) is one of the useful treatment for treating diseases that cause pancreatic duct stenosis. However, if the stenosis is severe, accessories other than the guide wire cannot pass through. This makes the ERCP procedure difficult. At this time, cystotome, a type of diathermic dilator seems to be an option. In this paper, we would like to discuss the experience of treatment procedures using cystotome.Methods: Patients who underwent ERCP at a single tertiary hospital from November 2019 to October 2022 were analyzed retrospectively. Among them, cystotome was used in eight procedures in seven patients who passed the guide wire but failed to pass the stenosis.Results: Technical success was achieved in all eight times. All the balloon catheter smoothly passed through the stenosis after cystotome was performed. In the second ERCP, it was a functional success for the balloon catheter to pass through stenosis without further treatment. This was achieved in 6 out of 8 (75.0%). In the case of complications, only one of the total successful procedures developed mild pancreatitis, which led to additional hospitalization for about two days after the procedure, and improved after conservative treatment.Conclusions: Based on this, cystotome seems to be a good option as an alternative treatment to severe stenosis of the pancreatic duct.
A Case of Complete Remission from Pancreatic Cancer Following Palliative Chemotherapy
Authors: Lee Jae Jin , Jeong Han Taek , Bae June Hwa
Published: November 2023

The prognosis for pancreatic cancer is still poor with a 5-year survival rate around 10%. We report a case of complete remission after palliative chemotherapy for pancreatic cancer in a 61-year-old-female. She presented with indigestion and weight loss. A computed tomography scan revealed a 1.8 cm mass in the pancreatic head. Carbohydrate antigen 19-9 (CA 19-9) and carcinoembryonic antigen (CEA) levels were elevated. The patient underwent endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) and the pathologic examination showed adenocarcinoma. Positron emission tomography (PET) and magnetic resonance imaging (MRI) of the pancreas showed a metastatic nodule in the S6 segment of the liver and a metastatic portocaval lymph node. The final diagnosis was stage IV pancreatic cancer. The patient received 24 cycles of palliative FOLFIRINOX regimen. Response evaluation demonstrated disappearance of all the lesions. She underwent pyloruspreserving pancreatoduodenectomy (PPPD). The pathologic examination of the surgical specimen showed complete remission of the pancreatic cancer. The patient is currently undergoing adjuvant chemotherapy.
Previous anterior cruciate ligament reconstruction influences the complication rate of total knee arthroplasty: a systematic review and meta-analysis
Authors: Alessio-Mazzola Mattia , Placella Giacomo , Zagra Luigi , Leone Orlando , Di Fabio Natasha , Moharamzadeh Desiree , Salini Vincenzo
Published: November 2023

Purpose

The results of total knee arthroplasty (TKA) following anterior cruciate ligament (ACL) reconstruction are still under-investigated. The purpose of this research is to investigate the differences between TKA after ACL reconstruction and TKA for primary osteoarthritis through a review and meta-analysis of the literature.

Methods

Case–control and cohort studies reporting outcomes of TKA following ACL reconstruction were considered eligible for inclusion. The primary endpoint was to systematically review and meta-analyze the reported complications of TKA following ACL reconstruction. The outcomes have been compared with a group of patients who underwent TKA for primary knee osteoarthritis (OA) with any previous ACL surgery. Secondary endpoints were to assess and compare technical difficulties and results including the operative time, the use of revision components, the request for intraoperative release or additional procedures, the revision rate, and the clinical outcomes.

Results

Seven studies were included involving 1645 participants, 619 of whom underwent TKA in previous ACL reconstruction and 1026 TKA for primary OA with no previous ACL reconstruction. Meta-analysis showed that TKA in previous ACL reconstruction had a significantly higher complication rate (OR = 2.15, P < 0.001), longer operative times (mean differences (MD): 11.19 min; P < 0.001) and increased use of revision components (OR = 2.16; P < 0.001) when compared to the control group without differences of infection, and revision rate.

Conclusions

TKA in a previous ACL reconstruction has a significantly higher complication rate, longer operative times, and a higher need for revision components and intraoperative soft tissue releases in comparison to TKA for primary OA without previous ACL reconstruction.
The peculiarities of the escrow account contract under the legislation of Ukraine
Authors: Tarhoniy Yu.Ya
Published: November 2023

In the process of research, the analysis of peculiarities, subject matter, object, essential terms of the escrow account contract was made. Based on the study of the legal concept of this contract, it was concluded that it should be considered tripartite, and in some exceptional cases - bilateral. An exhaustive legislative regulation of the cases when the escrow contract can be bilateral, in particular, within the squeeze-out procedure, is proposed. In turn, the escrow contact must be tripartite if it is used in other areas, in particular, for trade settlements with counterparties, the subject of which are goods, services, intellectual property rights, as well as the purchase/sale of real estate, including relations between the developer and the investor .The positions of scientists regarding the moment of concluding of the contract were analyzed. It was researched, that the escrow contract is consensual. It was found out, that one more peculiarity of the contract is reciprocity. The subject matter and the object of the escrow account contract are differentiated: cash in non-cash form should be considered the object of the contract, and the actions of the client (account holder) concerning the transfer of funds to the bank for safekeeping, as well as the actions of the bank regarding the preservation of these funds and their transfer to the beneficiary after the occurrence of the grounds specified in the contract - should be considered the subject matter of the contract. It was found out that the essential terms of the escrow contract are the subject matter of the contract and the grounds for transferring to the beneficiary the funds received from the account holder and/or from third parties, or their return to the account holder(s) or third parties, and the term of the contract.
Working together nets a 52% return
Authors: Walker Michael
Published: November 2023

Canada's optometrists worked together again this spring to stage a cooperative television campaign. This cooperative effort resulted in a 52% return on investment. In other words, for every dollar contributed to the advertising fund by the provincial associa­tions, the campaign delivered an average $1.52 worth of value.
An Overview of Dry Eye Disease for Eye Care Professionals in Canada
Authors: Chan Clara C.
Published: November 2023

Dry eye disease (DED) is a multifactorial ocular surface condition that is highly prevalent and often chronic, with significant associated burden. The 2017 report from the Tear Film & Ocular Surface Society Dry Eye Workshop II (TFOS DEWS II) is an in-depth look at all aspects of DED. Although TFOS DEWS II has comprehensively defined and classified the disease and summarized the current DED literature on a global scale, it does not highlight country-specific aspects of DED diagnosis and treatment options. In this review, we provide an overview of DED in the Canadian context, with an emphasis on DED identification, diagnosis, and treatment options available in Canada. In addition, we discuss needs and opportunities within the Canadian ophthalmic community regarding DED.
Interface vitréomaculaire : Série de cas d’adhérence et de traction
Authors: Curry Jeffery T , Wingard Michael
Published: November 2023

L’interface vitréomaculaire a toujours été difficile à évaluer sur le plan clinique. Cependant, avec l’avènement de la tomographie par cohérence optique, les pathologies à cette interface sont plus faciles à diagnostiquer et à surveiller. Les attaches de l’interface vitréomaculaire sont diverses, allant de l’adhérence sans changement de la structure fovéale, comme l’adhérence vitréomaculaire, aux tractions entraînant un changement de structure, comme la traction vitréomaculaire. Bon nombre de ces pathologies peuvent être observées et prises en charge par un optométriste sans consulter un spécialiste de la rétine. Cet article décrit trois cas de pathologie vitréomaculaire accompagnés d’un examen du système de classement, de présentations qui ont été associées à une incidence plus élevée de libération spontanée et d’options de traitement.
Refractive Surgery: Part 1. Long-term Outcomes
Authors: Eltis Mark
Published: November 2023

While LASIK and PRK have been employed for two decades, there are few long-term studies on refractive surgery. This paper analyzes the long-term outcomes of LASIK and PRK and reviews the risks, benefits, and technological breakthroughs of these procedures. Rates and causes of patient satisfaction are discussed in detail.  Alternative techniques such as small-incision lenticule extraction (SMILE) and surgical options for presbyopia are also explored.
Chirurgie réfractive : Partie 2. Complications et progrès récents
Authors: Eltis Mark
Published: November 2023

Bien que le LASIK et la PKR soient utilisés depuis vingt ans, il y a eu peu d’études à long terme sur la chirurgie réfractive. La présente étude a examiné les résultats à long terme du LASIK et de la PKR et a analysé les risques, les avantages et les percées technologiques de ces procédures. Les taux et les causes de la satisfaction des patients sont discutés en détail. Les autres possibilités telles que l’extraction d’un lenticule par petite incision (SMILE) et les options chirurgicales pour la presbytie sont également explorées.
Concordance With the Social Goals of Post-War Recovery in the Formation and Use of Ukrainian Local Budget Funds
Authors: SOVA OLENA. OLENA
Published: November 2023

The results of reforming the system of interbudgetary relations in Ukraine are studied in terms of the degree of local self-government participation in solving regional development problems. Normative and legal acts, which introduced changes in the functioning of administrations in wartime and changed the procedure for budget planning and reporting, are singled out. The paper offers options for dividing the country into functional types of territories to stimulate their direct financing. Emphasis is placed on the established norm regarding the mandatory preparation of a development strategy for each community. Attention is focused on the need to strengthen interstate partnership in the process of post-war reconstruction of the country and the implementation of European experience in the legislative regulation of regional development. The possibility of applying the European concept «S3» in Ukraine as a policy of determining priorities for the development of regions on the basis of smart specialization is outlined. The changes in the sources of revenues to the local budgets of Ukraine and the directions of their use for the purposes of post-war reconstruction are clearly presented and substantiated. Incomes and expenditures of local budgets for 2018—2022 have been analyzed. The interbudgetary transfer line items are singled out with the provision of proposals for the implementation of the system of vertical-horizontal equalization of communities’ capacity. The community sector’s levers of influence on the processes of local budget funds allocation in order to strengthen social ties and increase the social capital of territorial communities are determined. An assessment of changes in the structure of local budgets’ own revenues and in the composition of financed programs is carried out. Subsidization trends have been systematized and the subsidy level of community budgets has been determined. The advantages of the carried out budget decentralization reform and its next steps are argued. Proposals for measures to improve the communication policy in relations between state authorities, local self-government bodies and territorial communities are provided.
Пневматичні регулятори в установках одержання інертних газів
Authors: Симоненко Ю.М. , Медушевський Є.В. , Костенко Є.В.
Published: November 2023

У статті відображено сфери використання пневматичних захисних та регулюючих пристроїв при збагаченні газових концентратів. Розглянуто основні типи редукторів. Наведено приклади технологічних схем, заснованих на застосуванні пневматичних регуляторів. Редуктори типу «після себе» слугують для зниження тиску газу, що подається з ресиверів високого тиску, групи балонів і реципієнтів. Включення таких регуляторів дозволяє знижувати вхідний тиск до рівня, відповідного характеристикам компресорів чи технологічним режимам установок. Редуктори «до себе» слугують для стабілізації тиску в апаратах-джерелах газових концентратів. При відборі у фазовий сепаратор (дефлегматор) Ne-He суміші з ряду різнотипних повітророздільних установок такі регулятори здатні забезпечити узгоджену роботу кількох блоків та виключити перетікання суміші та порушення повітророзділення. Редуктори «до себе» можуть виконувати функції превентивної захисної арматури поряд з типовими запобіжними клапанами. На відміну від останніх, регулятори «до себе» мають більшу чутливість і здатні знижувати тиск в установці плавно, не порушуючи технологічний процес. У цьому випадку регулятори налаштовують на 0,2...0,3 МПа нижче тиску спрацьовування основного запобіжного клапана. Наведено приклади контурів, заснованих на використанні пневморегуляторів у системах збагачення інертних газів. Розглянуто випадок відбору суміші безпосередньо з джерела і подавання рівномірно в колону з підвищеним (щодо джерела) тиском. Такий варіант передбачає  узгодження витрати компресора з продуктивністю колони за рахунок використання періодичного компримування та ресиверів. Розрахункові моделі дозволяють прогнозувати зміну тиску протягом циклу. Залежно від продуктивності установки обчислюється мінімальний обсяг ресивера, що забезпечує безперервність подачі суміші у колону. Запропоновані схемні рішення дозволяють забезпечити стабільну роботу установок для збагачення концентратів інертних газів
EN Energy efficiency improvement for the older reefer vessel by the combined compression-ejector refrigeration machine
Authors: Ялама В.В. , Хмельнюк М.Г.
Published: November 2023

A marine combined compression-ejector refrigeration machine that comprises conventional refrigeration and air-conditioning system using single-stage refrigeration machine and an ejector refrigeration machine is proposed and studied. The ejector refrigeration machine is driven by the waste heat from the single-stage refrigeration machine and acts as the bottom cycle of the single-stage refrigeration machine. A system analysis shows that the COP of a compression-ejector refrigeration machine is significantly higher than a one-stage refrigeration system. Improvement in COP can be as high as 19.3% for evaporating temperature of the single-stage refrigeration machine Tc at -40°C. Influence of flowing part of ejector profile, operating parameters, scheme and cycle of the marine combined compression-ejector refrigeration machine on its performance characteristics is shown. Rational methods to increase efficiency of marine combined compression-ejector refrigeration machine, operating with environmentally friendly low-boiling refrigerant R245fa, are offered and investigated. The present study shows that the combined compression-ejector refrigeration machine using the ejector refrigeration machine as the bottom cycle of the one-stage refrigeration machine is viable. The opportunities of implementing solar panels, raised challenges for older reefer vessels (20-40years) force to analyse situation. While opportunities exist for efficiency improvement and environmental alignment, challenges in retrofitting older vessels, especially those nearing the end of their operational life, make economic viability a critical consideration. The analysis of the possible solar panel application estimates a cost range of 398,269.20 to 426,717.00 euros, emphasizing the need for careful evaluation. The conclusion advocates against implementing solar panels on the researched vessel, highlighting the lack of justification in both economic and operational efficiency aspects
Factors determining the prognosis after elective myocardial revascularization in patients with coronary artery disease with multifocal atherosclerosis
Authors: Khakimova M. B. , Komarov A. L. , Krivosheeva E. N. , Mironov V. M. , Kurbanov S. K. , Kuzyakina S. O. , Yarovaya E. B. , Panchenko E. P.
Published: November 2023

Aim. To identify factors determining the prognosis after elective myocardial revascularization in patients with coronary artery disease (CAD) with multifocal atherosclerosis (MFA).

Material and methods. The study is based on the prospective registry REGATA-1, ClinicalTrials NCT04347200 (1500 patients with stable coronary artery disease; men, 78,6%, age, 65±8,7 years). We selected 238 patients with MFA, the criteria of which were multivessel CAD (at least 2 arteries) in combination with stenosis ≥50% of at least one of the peripheral vascular system. The selection criteria was elective myocardial revascularization followed by dual antiplatelet therapy for at least 6-12 months. Unfavorable outcomes were analyzed, namely thrombotic events (TEs) in any vascular system and bleeding (BARC type 2-5).

Results. The median follow-up was 859 days (interquartile range [523;1665]). Thrombosis dominated in the structure of events: the total incidence of TEs was 18,5% (including fatal — 4,2%), and the total incidence of bleeding was 7,5% (including BARC type 3 — 1,7%). Predictors of TE were smoking (hazard ratio (HR)=2,18), myocardial infarction (HR=2,6) and ischemic stroke/transient ischemic attack (HR=2,81) more than a year ago, as well as revascularization with percutaneous coronary intervention (PCI) versus coronary artery bypass grafting. For PCI, the prognosis was worse in case of incomplete revascularization, as well as when the intervention was limited to ≤2 arterial segments and the total length of stents <26 mm. Among all predictors of poor prognosis, the most significant was high-risk PCI in combination with dual antiplatelet therapy for <12 months (HR=6,7).

Conclusion. For the first time, TE predictors in patients with CAD and MFA have been identified, which will improve secondary prevention in a category of patients with an extremely high risk of TEs.
Influencia de la satisfacción laboral en el desempeño del personal del Ministerio de Trabajo y Promoción del Empleo, 2023
Authors: Santiago Blanca D.
Published: November 2023

La investigación tiene como principal objetivo determinar la influencia de la satisfacción laboral en el desempeño del personal del Ministerio de Trabajo y Promoción del Empleo, usando datos de corte transversal en 2023, empleando una encuesta de confiabilidad validada. La información recogida arroja que el 58% del personal expresa tener sólo un nivel regular de satisfacción personal, indicando como elemento más positivo el reto que le demanda el trabajo de su puesto y la retribución al esfuerzo uno en el que la entidad debería mejorar. El 81.3% manifiesta llevar a cabo un adecuado desempeño laboral, destacando sus relaciones laborales y señalando al trabajo en equipo como una dimensión en la que debe mejorarse.

Se concluye que la satisfacción laboral influye significativamente en el desempeño del personal obteniendo un estadístico chi-cuadrado = 118,477 (p = 0,000) y el R2 de Nagelkerke = 0,490. De forma similar, existe influencia de parte de cada una de las dimensiones que componen la variable independiente (Trabajo desafiante, condiciones laborales, apoyo institucional y retribución al esfuerzo).
Clozapine Dose-Concentration Relationship and Other Factors Associated With Clozapine Plasma Concentration in Korean Schizophrenia Patients
Authors: Ryu Seonghyeon , Cho Gyeonghyeong
Published: November 2023

Objectives: Some reports suggest that the concentration-to-dosage ratio (C/D ratio) of clozapine (CZP) in Asian treatment-resistant schizophrenia (TRS) patients differs from that of Caucasian TRS patients. However, there is insufficient research on the differences in C/D ratio between Korean TRS patients and Caucasian TRS patients. Therefore, this study aimed to investigate prescribed CZP dosage, CZP concentration and C/D ratio in Korean TRS patients.Methods: The study included TRS patients aged 18 years or older who were prescribed CZP for at least 12 weeks at a psychiatric hospital in Korea. We collected demographic information, smoking status, hospitalization status, CZP serum concentration, total CZP dosage, and norclozapine (NCZP) serum concentration and analyzed their statistical correlations.Results: The study found that the average daily CZP dosage was 266.1 mg, and the average CZP concentration was 568.0 ng/mL. There was a significant correlation between CZP serum concentration and smoking status, as well as sex. CZP dosage was not significantly associated with age, weight, BMI, or metabolic rate. The study also found a significant difference in C/D ratio between groups based on CZP serum concentration.Conclusion: Our study suggests that recommended CZP dosages for Caucasians may not be suitable for Koreans due to C/D ratio differences. We found a relationship between CZP serum concentration and C/D ratio in Korean TRS patients. Therefore, it is crucial to confirm CZP serum concentration to avoid side effects and to find optimal dosage.
An International Adult Guideline for Making Clozapine Titration Safer by Using Ancestry-Based Personalized Dosing Titrations, C-Reactive Protein and Serum Clozapine Levels: Korean Translation and Its Clinical Application Cases
Authors: Park Jung Su , Kang Nuree , Ahn Yong Min , Kim Yong Sik , Kim Se Hyun
Published: November 2023

Objectives: During the initial clozapine titration, it is crucial to monitor for inflammatory reactions to ensure safe and effective administration. Clozapine metabolism varies by ancestry, particularly among Asians, warranting lower dosage. Recently, Dr. De Leon introduced guidelines based on ancestral differences. We aimed to provide a Korean translation, focusing on illustrating the necessity through clinical cases.Methods: The Korean translation of the guidelines, approved by Dr. De Leon, involved two psychiatrists who reviewed and revised each other’s work. An additional board-certified psychiatrist conducted an independent review. We examined two clinical cases from our institution’s database, where clozapine titration faced challenges due to fever and pneumonia, assessing guideline applicability.Results: The guidelines recommend a target clozapine dose of 175-300 mg/day for Asians with average metabolism and a slower titration rate compared to other ancestries. In both cases, CRP elevation was detected either before or simultaneously with the onset of fever, with a concentration-to-dose ratio ranging from 3.06 to 6.97.Conclusion: The initial clozapine titration process should consider metabolic differences by ancestry and monitor for inflammation. Further research is needed to optimize the titration process for Koreans, considering metabolic rates, usage patterns, and side effects.
A study on the effects of perceived value perception of online travel agencies on users' continuous use intention: Application of value based acceptance model and expectation confirmation model
Authors:   The Tourism Sciences Society Of Korea, Lee Yeonju , Yoon Ji-Hwan
Published: November 2023

Looking at online travel agency users, the objectives of this study were (1) to derive the subfactors of perceived benefits and perceived sacrifices and (2) to identify antecedents to intention to continue using the service, level of satisfaction with it, and degree of confidence in expected outcomes. The Value-based Acceptance Model (VAM) and the Expectation Confirmation Model (ECM) provided theoretical underpinnings. Descriptive statistics were used to identify the sample's characteristics, and structural equation modeling was used to test the model fit and the relationships between the constructs. The subfactors of perceived benefits were usefulness, enjoyment, and economic benefits, whereas perceived sacrifices consisted of security risks, financial risks, and service distrust. All subfactors of perceived benefits (i.e., usefulness, enjoyment, and economic benefits) exerted positive impacts on perceived value with usefulness being the most influential antecedent. Among the perceived sacrifice factors, security risks and service distrust negatively influenced perceived value. When users' OTA experiences coincided with their expectations, this promoted their perceived usefulness, which then enhanced their satisfaction. Perceived value positively impacted satisfaction and continued use intention.
Yükselen Piyasa Ekonomilerinde Teknolojik Gelişim ve İşsizlik İlişkisinin İncelenmesi: Dinamik Panel Veri Analizi
Authors: MANGA Serkan , TUNA Abdulkadir
Published: November 2023

İktisat literatürü, teknolojik yeniliklerin ekonomik büyüme üzerinde katalizör etkisine sahip olduğu konusunda fikir birliği içerisindedir. Buna karşın, teknolojik yeniliklerin işsizlik üzerine etkileri konusunda tartışmalar devam etmektedir. Bu çalışmada; yükselen piyasa ekonomilerindeki teknolojik gelişimin, işsizlik üzerindeki etkisi incelenmiştir. Yükselen piyasa ekonomileri, gelişmekte olan ülkeler grubu içerisinde yer almasına karşın, bazı nitelikler nedeniyle gelişmiş ülkelere benzemektedirler. Yüksek ekonomik büyüme performansına sahip bu gruptaki ülkelerde, aynı zamanda yüksek işsizlik ile mücadele etmektedir. Çalışmanın bulgularına göre; yükselen piyasa ekonomilerinde teknolojik gelişim ile işsizlik arasında negatif ilişki tespit edilmiştir. İlişkinin negatif yönde olduğu fakat kuvvetinin zayıf olduğu görülmüştür.
Digital Biomarkers for Alzheimer’s Disease
Authors: Kim Ye Lin , Shin Byoung-Soo , Kim Ko Woon
Published: November 2023

There is a growing interest in developing new biomarkers using digital devices. The primary purpose of digital biomarkers is to obtain features based on multi-dimensional data such as multiple data sources from various digital devices and time-series data reflecting temporal changes. Therefore, digital biomarkers can be used to measure the behavioral patterns of individuals in their daily lives in contrast to traditional biomarkers that reflect specific time points in clinical or laboratory settings. However, there are still several limitations including validation and interpretation. This article reviews the potential of digital biomarkers, explores previous studies on digital phenotypes related to Alzheimer’s disease, and discusses the future challenges of implementing digital biomarkers in the medical field.
Stroke in a Young Age COVID-19 Patient: Vasculitis Feature and Changes in Cerebral Vessel Stenosis
Authors: Oh Hyunsun , Kim Kijeong , Chang Jun Young
Published: November 2023

Recent studies have shown that coronavirus disease-2019 (COVID-19) infection increased risk of stroke. Significant differences have been identified between the general population and COVID-19 stroke patients. There are unusual patterns of stroke occurred in COVID-19 patient are reported. Pathophysiologic theories about the relationship of COVID-19 infection and stroke are being published. Herein we report a rare case of stroke in a young COVID-19 patient, considered to be the result of vasculitis, and vessel changes that might have been caused by vasospasm based on serial brain imaging follow-up data. And we interpret this case based on pathophysiological characteristics of the severe acute respiratory syndrome coronavirus 2.
Uncovering Digital Competence in Language Instruction: A Study of Pre-Service English Teachers in Saudi Arabi
Authors: Al Khateeb Ahmed
Published: November 2023

the role of technology as a catalyst for change and development has become irrefutable in various language learning settings. However, not all language teachers are mindful about using technology in their language teaching practices, owing to their lack of adequate digital competencies. The purpose of this research is to promote digital competencies and related components among the study participants. This investigation applies the Framework of Competency Profile for digital teachers. The results were obtained by quantitative analysis, using data collected from a sample of 151 language learners, all enrolled in BA English language programmes across 8 universities in Saudi Arabia. These learners are considered pre-service English language teachers, as they are near graduation. The findings demonstrated participants’ highest and lowest digital competences, leading the researcher to identify practical implications, particularly regarding how to conduct training to compensate for low competencies. The findings also revealed that there is no correlation between levels of study and digital competencies. There was also no influence of gender on digital competencies. From these findings, the researcher concluded that the identification of competencies is essential for instructors, educators, administrators, and policymakers, in order to design more effective and appropriate training programmes for teachers in each context. Finally, the findings provided realistic analysis of the components and sub-components related to digital competencies among the target audience.
Factors Affecting the Improvement of Speaking Skills Among Jordanian EFL Learners
Authors: Khasawneh Mohamad Ahmad Saleem
Published: November 2023

The purpose of this research was to investigate the factors affecting the improvement of speaking skills among Jordanian students of English as a foreign language. This objective was reached by concentrating on educational tools, instructional strategies, and the mistakes made by students that have an impact on their skill to speak English from the perspective of students at Irbid National University and Jadara University. 316 students took part in this research project as part of the sample. In this study, a quantitative research design was used, and the participants were each given a customized version of the questionnaire that was used to collect data for the study. According to the findings, educational tools are used extensively in university settings. In addition, the findings demonstrated that the instructional strategies and the mistakes made by the students had a moderate impact on the students' skills to speak English.
Clinical and genetic characteristics of type 7 distal arthrogryposis caused by a pathogenic variant in the MYH8 gene
Authors: Sharkova I. V. , Nikitin S. S. , Markova T. V. , Voskanyan A. E. , Melnik E. A. , Shchagina O. A. , Dadali E. L.
Published: November 2023

Distal arthrogryposis is a group of genetically heterogeneous congenital diseases characterized by non-progressive contractures predominantly distal joints of the upper and lower extremities. 11 genes have been identified as pathogenic variants causing the occurrence of autosomal dominant and autosomal recessive types of distal arthrogryposis. Almost all products of these genes are expressed in the structures of the neuromuscular system, which makes it possible to classify distal arthrogryposis as a neuromuscular disease. Type 7 distal arthrogryposis is a rare autosomal dominant disease characterized by two main symptoms: mandibular trismus and pseudocamptodactyly, a specific symptom of limited mobility of the interphalangeal joints during hand dorsiflexion with no restriction during palmar flexion. In all patients described in the literature from different populations with type 7 distal arthrogryposis, the same pathogenic variant c.2021G>A(p.Arg674Gln) was found in the MYH8 gene, the protein product of which is one of the myosin isoforms functioning in the embryonic period and providing the formation of muscle fiber structures.

The aim of the work is to describe the clinical and genetic characteristics of the first family case of type 7 distal arthrogryposis in Russian patients. The patients underwent clinical examination and electromyography. Exome sequencing after DNA isolation from the proband’s blood according to the standard method was carried out on the NextSeq 500 platform (Illumina, USA) using the pairedend reading method (2 × 75 bp). Confirmation of the pathogenicity of the identified variants was carried out using automatic Sanger sequencing.

As a result of molecular genetic analysis in a father and son with clinical manifestations of type 7 distal arthrogryposis, a heterozygous c.2021G>A variant in exon 18 of the MYH8 gene, which was previously described in all patients published in the literature, was detected, leading to the replacement of p.Arg674Gln(NM_002472.2) in a protein molecule. The examined patients did not reveal focal neurological symptoms, as well as minor developmental abnomalities, pathology of internal organs, ulnar deviations, equinovarus feet deformities, vertical orientation of the talus, contractures of the hip joints, which were found with varying frequency in previously described patients with variants in the MYH8 gene. Specific clinical signs of type 7 distal arthrogryposis, combined with the presence of a major nucleotide variant, make it possible to optimize the process of molecular genetic diagnosis of this type of hereditary arthrogryposis.
The Nature of Truth: Theories and Reflections
Authors: Batista Ricardo Barroso , Galvão Artur Ilharco
Published: November 2023

Truth is one of the main concepts of Philosophy, some even consider it the most important of all (W. Künne). This concept is also a foundation for other philosophical concepts. Some of them even depend intrinsically on it, such as the concepts of belief (to believe in something is to believe this something is true), knowledge (if you know something then that something is true), fact (facts are what make our statements true), existence (true reality is the external world that exists) and modality (there are propositions that can be true in all possible worlds), among many others. Truth is also a crucial concept for other domains. Science is said to be the search for the truth of the Natural World and the good life is said to be the pursuit of the good (Aristotle). If one considers that the good and the just are objects of knowledge (R. Campbell), then, there could be no good or justice without truth, insofar as knowledge needs truth. Also, our confidence in the robustness of western political and social institutions has always rested on truth. Unfortunately, this basis, which is the foundation of trust and, therefore, of the robustness of our institutions, is being eroded by external forces, deniers and nihilists, by undermining the concept of Truth, endangering in that way the democratic model (H. Frankfurt). The troubled events we have recently experienced – the raise of populisms, conspiracy theories, pandemic skepticism, the conflict in Ukraine not only in the battleground but also in the info space – could, to some extent, make us question whether, in fact, there is still any theoretical interest in “truth”. As several authors have noted, it seems that today we live in a society of “post-truth” (A. Szakolczai) or “veritophobia” (A. Goldman), where lies are tolerated and facts ignored. Also, for this reason, understanding what truth is by reflecting on its nature and function, from the most sophisticated conceptual schemes to its most everyday uses, seems to be a philosophical task of the utmost importance. This is why the Revista Portuguesa de Filosofia has decided to dedicate this special issue to the subject of truth.
La «verità come indefinito differirsi del reale». Le ragioni del realismo pluralistico
Authors: Di Chiro Antonio
Published: November 2023

The aim of this paper is to propose a theory of pluralistic realism, i.e. a theory that presents an idea of reality that embraces multiplicity both at an ontological and epistemological level. The basic ideal of this theory is that reality is inexhaustibly multifaceted and that, therefore, the ways in which human beings can account for it are diverse and multiple. This idea of reality also implies an idea of plural truth, i.e. as an openness and acceptance of diversity and difference which can act as an antidote to the resurgence of fundamentalisms and totalitarian visions of reality based on the refusal of diversity, on the lack of ethical recognition-political-social difference and on the tendency to believe that one’s own reality and therefore one’s culture, one’s nation, one’s country are objectively superior to other realities, nations, countries, cultures. In proposing the reasons for this theory we will try to integrate Mario De Caro’s philosophical proposal of a «liberalized naturalism» or «pluralistic realism» with the phenomenological perspective of Vincenzo Costa based on the idea that reality is determined on the basis of the experience of the human subject.
Hospitalidade e conflito: o problema do “reconhecimento” no acolhimento de refugiados
Authors: De Angelis Gabriele
Published: November 2023

This article explores the philosophical complexities of asylum and refugee reception, critiquing both continental and analytical traditions while proposing a phenomenological method to bridge theory and praxis. It highlights the analytical tradition’s focus on formal rights and obligations, and contrasts this with insights from the continental tradition and Hannah Arendt’s experiential perspective on asylum. The paper advocates for a comprehensive theory of hospitality, aiming to reconcile formal rights with the lived experiences of refugees, ultimately striving for a balanced understanding and better facilitation of mutual recognition and integration.