bluuebunny/crossref_metadata_2025 huggingface dataset:
Downregulation of LncRNA-MEG3 promotes HTR8/SVneo cells apoptosis and attenuates its migration by repressing Notch1 signal in preeclampsia
Authors: Wang Rongli , Zou Li
Published: April 2020

A successful pregnancy crucially depends on well-regulated extravillous trophoblast migration and invasion. Maternally expressed gene 3 (MEG3) is a long noncoding RNA that plays an important role in regulating trophoblast cells cell function. As previously reported, the expression of MEG3 was reduced in preeclampsia, and downregulation of MEG3 could suppress trophoblast cells migration and promote its apoptosis. However, the downstream regulatory mechanism of MEG3 remains unknown. As reported, MEG3 could inhibit cell proliferation in endometrial carcinoma by regulating Notch signaling. Our previous studies have demonstrated that Notch1 is downregulated in preeclampsia and that inhibiting the expression of Notch1 could promote trophoblast cell apoptosis. Therefore, this study was designed to investigate the role of MEG3 and its the relationship with Notch1 in trophoblasts. In this study, the mRNA expression levels of both MEG3 and Notch1 were decreased in preeclampsia placenta (n = 15) compared to the normal samples (n = 15). Exogenous upregulation and downregulation of MEG3 in HTR8/SVneo cells were performed to investigate the role of MEG3 in cell biological behavior and its effects on Notch1 expression. The results showed that MEG3 enhancement promoted trophoblast cell migration and invasion and inhibited cell apoptosis. Downregulation of MEG3 elicited the opposite results. Associated factors, such as matrix metalloproteinases 2 (MMP2), BAX, and Bcl-2, were examined at the mRNA and protein levels. Our study demonstrated that MEG3 could regulate Notch1 expression to modulate trophoblast cell migration, invasion, and apoptosis, which may represent the molecular mechanism of poor placentation during preeclampsia.
Прояви психологічних проблем гендерного характеру в організаціях
Authors: Куравська Надія
Published: April 2020

Стаття присвячена аналізу проблеми гендеру в організаціях. Виділяються та характеризуються головні психологічні проблеми, які виникають в організаціях і мають гендерно зумовлений характер. Зокрема йдеться про гендерну дискримінацію, сексизм, гендерні та сексуальні домагання, насильство. Коротко описуються негативні наслідки цих явищ.
Scientific and technical support of production of thermoplastic materials for road marking
Authors: Talalai Viktor , Vasiliev Yuri , Kochetkov Vladimir
Published: April 2020

The basis of the technological evaluation of the composition of thermoplastic for road marking is the calculation of production costs associated with a particular technological scheme. In the most General form, any process for obtaining marking thermoplastics consists of the following technological operations: preparation of components; preparation of thermoplastic mixture; rastarivanie and packaging.

In principle, such schemes currently exist two: a scheme that determines the production of thermoplastics in the form of a dry mechanical mixture; a scheme that determines the production of thermoplastics in the form of homogeneous fused blocks.

Mixing of all components according to the first scheme in the mixer is made within three-five minutes. During mixing, liquid components are added to the mixer, if the latter are provided by the formulation. The finished mixture is discharged through a hole in the bottom of the mixer body.

Production under the second scheme has a number of undoubted advantages. This is a thorough dispersion of the components that make up the thermoplastic, which ensures uniformity of its properties in any part of the batch of manufactured material. When transporting the thermoplastic in the container does not require the shelter from atmospheric precipitation and can be stored for unlimited time in unheated warehouses.

From the given data it is visible that the developed compositions received as a result of performance of the present work, in comparison with analog possess the raised adhesion to asphalt concrete and elasticity in a temperature range from -10 oC to 20 oC. These indicators allow to draw a conclusion about the best resistance of the developed material in operating conditions, especially at negative temperatures.
Determination of the coefficient of adhesion of the wheels of vehicles with road markings
Authors: Goncharova Margarita , Bondarev Boris , Akchurin Talgat
Published: April 2020

Possibilities of application of DIN EN 13036-4 Characteristics of road and airfield covering are considered. Test method. Part 4. Method of measurement of sliding resistance. Testing with a pendulum device to assess the coefficient of adhesion of road markings. This method is not applicable for diagnostics and more advanced scientific studies of rough and cohesive properties of road surfaces.

The standard can be useful to control coupling properties of road markings, airfield pavements, examination of traffic accidents or for additional evaluate and evaluate the quality of road works, which, however, can be much better resolved based on domestic indicators standard deviation raznovysotnyh of Krasnoglinsky and raznolikosti geometry mikroheranhvatho road surface.
Research of the influence of induction heating on the strength characteristics of steel 10HSND
Authors: Usoltsev Andrei
Published: April 2020

In the production of welded spans of railway bridges since the 70s of the last century, low-alloy structural steels are used. In these constructions in recent years there has been an intensive growth in the formation of fatigue cracks. Currently, the only technology used by Russian Railways for braking fatigue cracks is to drill a hole in the mouth of a crack, followed by setting a high-strength bolt into it and tightening it to a standard force. At the Siberian Research Institute of Bridges (Siberian Research Institute of Bridges SGUPS), innovative technologies have been developed to inhibit the growth of fatigue cracks and strengthen welded spans using soldering and induction heating. Technology has proven effective. It is known that heating a metal to high temperatures can significantly change its structure and characteristics. In the scientific literature there are no data on changes in the strength characteristics of low alloy structural steels as a result of rapid heating. In a laboratory study, an analysis was made of the change in the strength characteristics of low alloy structural steel with rapid induction heating. Studies of structural steel samples showed that quick short-term induction heating of structural steel to the temperature of brazing does not lead to a significant change in its strength characteristics, and brazing and induction heating can be used to strengthen structures with fatigue cracks.
COVID-19 no Estado do Ceará: Comportamentos e crenças na chegada da pandemia
Authors: Lima Danilo , Dias Aldo , Rabelo Renata , Cruz Igor , Costa Samuel , Nigri Flávia , Neri Jiovanne
Published: April 2020

O objetivo deste estudo foi avaliar os aspectos comportamentais e as crenças da população cearense frente a pandemia de COVID-19. Foi realizado um questionário onlinesobre aspectos sociodemográficos e opiniões relacionados a pandemia. Foram calculadas frequências absoluta e relativa, a associação entre variáveis foi realizada comQui-quadrado eo nível de significância foi de 5%. A amostra final contou com 2.259 participantes e foi observada associação entre o gênero feminino com um alto risco de contaminação (p=0,044) e o gênero masculino com a não realização voluntária da quarentena (p<0,001). Pessoas com 80 anos ou mais realizaram quarentena parcialmente devido ao fluxo de pessoas em casa (p<0,001).Os participantes com o ensino fundamental consideraram que estão em um nível de risco menos alto que os participantes com grau de escolaridade mais elevado (p<0,001). Neste grupo estão as pessoas que menos fizeram quarentena voluntária (p<0,001). Os participantes que moram no interior do Estado, tiveram menos contato direto com alguém testado positivamente para o coronavírus (p=0,031) e estão menos reclusos (p<0,001).É possível concluir que a abordagem frente a pandemia de COVID-19 varia de acordo com aspectos sociais, como gênero, idade, escolaridade e local de residência, assim como o sistema de crenças da população do Estado do Ceará.
Distal Migration and Ectopic Eruption of the Mandibular First Premolar: Case Report
Authors: Fux-Noy Avia
Published: April 2020

Migration describes the movement of an unerupted tooth within the bone when normal eruption is prevented and the tooth leaves its normal site of development. This report describes a case of distal migration and ectopic eruption of the mandibular first premolar in an 8.5-year-old boy. Following early extraction of the primary second molar, the first premolar migrated distally through the extraction site of the primary second molar and erupted into occlusion just mesial of the permanent first molar.
Pendeteksian petanda kepuncaan glioblastoma multiforme
Authors: Yohana Yohana
Published: April 2020

Glioblastoma multiforme (GBM) adalah tumor otak ganas yang memiliki populasi sel punca kanker yang dapat  mempertahankan formasi tumor. Peranan sel punca kanker telah banyak dipelajari yang memiliki tanggung jawab terhadap resistensi dan rekurensi terapi GBM seperti radiasi dan kemoterapi. Beberapa petanda kepuncaan dapat dipakai diantaranya CD133, Nestin, A2B5, CD44, SOX2 and OCT4. Pemeriksaan histopatologi terhadap jaringan tumor yang dioperasi menjadi standar baku untuk menentukan derajat, tingkat keganasan, dan prognosis keganasan. Namun di sisi lain, kehadiran populasi sel punca yang memiliki sifat mampu memperbaharui diri dan mampu menginduksi pembentukan tumor memerlukan pemeriksaan yang lebih mendalam mengenai karakteristik biologi sel tumor. Pemeriksaan  sel punca dilakukan menggunakan flowcytometry dan imunohistokimia.

Pemeriksaan petanda kepuncaan glioblastoma dilakukan dengan quantitative Reverse Transcriptase Real Time Polymerase Chain Reaction (qRT-PCR), Enzyme Linked Immunoabsorbent Assay (ELISA), Western Blot, Imunohistokimia dan flowcytometry. Petanda CD133 ditemukan ekspresinya meningkat pada berbagai pemeriksaan. CD133 digunakan sebagai prognostik GBM.
Aneurysmal bone cyst in proximal phalanx treated without bone grafting
Authors: R. S. Palanisami , Rajappa Srinivasan , . Raghavendran
Published: April 2020

Aneurysmal bone cyst involving the hand are a rare occurrence especially in the proximal phalanx. We report a case of 5 years old female child with proximal phalanx aneurysmal bone cyst treated without bone grafting. Magnetic resonance imaging may show fluid filled spaces but definite diagnosis can only be obtained histologically. It is a benign lesion still it can involve growth plate hence intervention is necessary. The treatment includes curettage with or without bone grafting.
Editorial
Authors: Carbajal Arroyo Luz
Published: April 2020

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Genome Wide Analysis of Severe Acute Respiratory Syndrome Coronavirus-2 Implicates World-Wide Circulatory Virus Strains Heterogeneity
Authors: Islam M. Rafiul , Hoque M. Nazmul , Rahman M. Shaminur , Puspo J. Akter , Akhter Masuda , Akter Salma , Rubayet-Ul-Alam A. S. M. , Sultana Munawar , Crandall Keith A. , Hossain M. Anwar
Published: April 2020

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel evolutionarily divergent RNA virus etiological agent of COVID-19, is responsible for present devastating pandemic respiratory illness. To explore the genomic signatures, we comprehensively analyzed 2,492 complete and/or near-complete genome sequences of SARS-CoV-2 strains reported from across the globe to the GISAID database up to 30 March 2020. Genome-wide annotations revealed 1,407 nucleotide-level mutations at different positions throughout the entire genome of SARS-CoV-2. Moreover, nucleotide deletion analysis found nine deletions throughout the genome, including in polyprotein (n=6), ORF10 (n=1) and 3´-UTR (n=2). Evidence from the systematic gene-level mutational and protein profile analyses revealed a large number of amino acid (aa) substitutions (n=722), making the viral proteins heterogeneous. Notably, residues of receptor-binding domain (RBD) having crucial interactions with angiotensin-converting enzyme 2 (ACE2), and cross-reacting neutralizing antibody were found to be conserved among the analyzed SARS-CoV-2 strains, except for replacement of Lysine with Arginine at 378 position of the cryptic epitope of a Shanghai isolate, hCoV-19/Shanghai/SH0007/2020 (EPI_ISL_416320). Our method of genome annotation is a promising tool for monitoring and tracking the epidemic, the associated genetic variants, and their implications for the development of effective control and prophylaxis strategy.
Penggunaan Regresi Kuantil Multivariat pada Perubahan Trombosit Pasien Demam Berdarah Dengue
Authors: Puteri Widya Nauli Amalia , Islamiyati Anna , Anisa Anisa
Published: April 2020

Quantile regression is an extension of the regression model of conditional quantile where the distribution is derived from the response variable expressed as a co-variate function. Quantile regression can model data that contain outliers. Patterns of platelet change in DHF patients based on body temperature and white blood cells were analyzed by quantile regression using θ = 0,25; 0,50, and 0,75. Based on the parameter estimation results, the quantile θ = 0,25 and 0,75 obtained variables that affect the platelets of DHF patients are white blood cells. Significant differences from the variables in each quantile occur because of the possibility of other factors that influence the platelets of DHF patients that are not contained in the model. The difference in the influence of factors on each quantile requires an appropriate adjustment of medical measures so that efficiency can be obtained in handling DHF patients.
Regresi Model Data Panel Efek Tetap dengan Metode Within Group pada Data Indeks Pembangunan Manusia Provinsi Sulawesi Selatan
Authors: Riyanti Hufaini Andi Sitti Fahmi , Raupong Raupong , Ilyas Nirwan
Published: April 2020

This research aims to describe the parameter estimation of the regression model on the panel data by approaches of Fixed Effects Model with within a group method. This research aims to determine the factors that influence the Human Development Index in South Sulawesi Province in 2011-2017 using Panel Data Regression Analysis. The regression model was obtained from the maximum likelihood estimation using within group approach using a mean for each independent variable and the dependent variable to find out the intercept differences in each city or cross-section that explains the effect of regional differences and to find out the intercept differences for cross sectional or time series. The results showed that the average length of the school variable (𝑋1) and life expectancy variable (X2) significantly affects the Human Development Index (Y) in the Province of South Sulawesi in 2011-2017.
Professional Stability…What You Can Do To Survive
Authors: Clementz David M.
Published: April 2020

Published in Oil & Gas Executive, Volume 1, Number 2, 1998, pages 34-39.

Our industry is, and has been, in turbulent times. When we talk of turbulence, we generally are referring to the downside of the peak in industry employment that followed the collapse of oil prices (Fig. 1). During 1982-92, the upstream oil and gas sector lost more than 50%of the jobs that were created in the preceding 10 years. For me, however, it was equally turbulent on the front side of the peak.

I was hired into Chevron's La Habra, California, laboratory in 1973, the first hire after nearly 4 years of a hiring freeze. The boom, related to the rise in oil prices, followed almost immediately. I worked in an exploratory research group that was looking for new ways to recover oil from old reservoirs. We had lots of wild ideas, and money for equipment and new laboratories was abundant. I then worked as a petroleum engineer in the Los Angeles basin doing million-dollar workovers to rejuvenate old wells. The rates of return were often more than 50%, and payout periods were less than 6 months. We had very clear guidance from senior corporate management: if we didn't spend our entire budget, they would find people who could. It was a time of double-digit pay raises - sometimes at 6-month intervals - and even "special" incentive payments. Oil was forecasted to be U.S. $50/bbl in a few years.

Before 1982, turbulence was created by too few resources chasing too many opportunities. After 1982, turbulence was created by the opposite condition - too many resources chasing too few opportunities. This led to excessive costs, which meant jobs had to be eliminated. Fig. 2 illustrates how severely the oil price collapse affected jobs in a number of industries during the 10 years following the peak, with the most severe effects in the oil and gas industry. It is particularly instructive to look at employment in the Fortune 100 oil and gas companies during the last 25 years (Table 1). In 1973, 14 oil and gas companies were in the Fortune 100 and accounted for nearly 700,000 jobs. Of those companies, 11 were in the top 50.
Corporate Risk Taking In the E&P Industry
Authors: Walls Michael R.
Published: April 2020

Published in Oil & Gas Executive Report, Volume 2, Number 2, 1999, pages 42-48.

E&P managers encounter a diverse and complex set of risky investment opportunities. As a result, risk-management decisions associated with E&P capital allocation are among the most conceptually difficult decisions to make. Because of this, managers are motivated to identify and to implement an appropriate risk policy - one that will help them sustain or improve their company's level of financial performance.

Managing risk in the petroleum E&P setting is a complex and critical task, with immediate and lasting effects on company performance. In today's environment of low oil prices, risk management is critical to the task of high, grading assets and investments. Although capital allocation is a primary driver of E&P success and managers face continued pressures to meet analyst expectations, companies are capital constrained. Success in this environment comes from evaluating all opportunities more effectively. An effective management approach includes articulating a risk management strategy that is consistent with a firm's willingness to take financial risk and acting on that strategy. Confronting the strategic issues of setting a risk policy and evaluating its effect on business-unit performance can lead to more effective decision making and improved positioning in a dynamic industry environment.

The increased use of more sophisticated tools - sensitivity analysis, Monte Carlo simulation, influence diagrams, decision-tree modeling, and the newer option-pricing theory - to model uncertainty and to value risky projects demonstrates the growing importance of risk management. This suggests that decision makers prefer to be consistent in their evaluation practices and to act consistently in their risk taking. However, complexities regarding investment risk and the willingness to take such risks often prevent a company from acting consistently. Moreover, in spite of advances in risk management techniques, little is known about the relationship between a company's willingness to take on financial risk and its performance. Identifying and acting on an appropriate corporate risk policy can go a long way toward improving the strategic decision making process.

The results of a recent industry study provide a better understanding of the implications of different levels of risk-taking behavior. The study extends earlier work that used a decision-analysis framework to measure implied risk propensities of U.S.-based oil companies during 1981-90 ("Risk Propensity and Firm Performance: A Study of the Petroleum Exploration Industry," Management Science, July 1996). The later study, which includes 40 of the top U.S.-based oil companies, extends the analysis through 1995 and reveals some important implications associated with setting an appropriate risk policy.
College Students Responding to the Chinese version of Cardiff Fertility Knowledge Scale Show Deficiencies in Their Awareness: A cross-sectional survey in Hunan, China
Authors: Zhou Yanhui , Luo Yang , Wang Ting , Cui Yanhui , Chen Mingzhu , Fu Jingxia
Published: April 2020

Background: Fertility knowledge is vital to the fertility health of young people and greatly impacts their fertility choices. Delayed childbearing has been increasing in high-income countries, accompanied by the risk of involuntary childlessness or having fewer children than desired. The aim of this study was to investigate knowledge about fertility issues, the related influencing factors, the method of acquiring fertility knowledge, and the relationship between fertility knowledge and fertility intentions among college students. Methods: An online cross-sectional survey of Chinese college students was conducted in Hunan Province from March to April 2018. A total of 867 college students from three comprehensive universities responded to a poster invitation utilizing the Chinese version of the Cardiff Fertility Knowledge Scale (CFKS-C). Data were explored and analysed by SPSS (version 22.0) software. Descriptive statistics, chi-squared tests, T-tests, and Pearson’s correlations were used for the measurements. Results: The average percent-correct score on the CFKS-C was 49.9% (SD=20.8), with greater knowledge significantly related to living in a city district, being not single status, majoring in medicine, being in year 4 or above of study, and intention to have children (all p＜0.05). A total of 81.9% of the participants reported that they would like to have children, the average score of the importance of childbearing was 6.3 (SD=2.7), and the female score was lower than the male score (p=0.001). A small positive relationship was observed between the CFKS-C and the importance of childbearing (r=0.074, p=0.035). Respondents indicated that they gained most of their knowledge from the media and internet (41.4%) and from schools (38.2%). Conclusion: Yong people in college have a modest level of fertility knowledge, a relatively low intention to have a child, and deficiencies in fertility health education. There is a need to improve the accessibility of fertility health services by developing a scientific and reliable fertility health promotion strategy.
Could age increase the strength of inverse association between ultraviolet B exposure and colorectal cancer?
Authors: Purushothaman Vidya Lakshmi , Cuomo Raphael E , Garland Cedric F , Mackey Tim Ken
Published: April 2020

Background: Vitamin D has been identified as a potential protective factor the development of colorectal cancer (CRC). We expect to see a stronger association of ultraviolet B (UVB) exposure and CRC crude rates with increasing age since chronic vitamin D deficiency leads to sustained molecular changes that increase cancer risk. The DINOMIT (disjunction, initiation, natural selection, overgrowth, metastasis, involution, and transition) model postulates various stages of cancer development due to vitamin D deficiency and the associated latency period. The purpose of this study is to examine this age-dependent inverse relationship globally.Methods: In this ecological study, a series of linear and polynomial regression tests were performed between country specific UVB estimates adjusted for cloud cover and crude incidence rates of CRC for different age groups. Multiple linear regression was used to investigate the association between crude incidence rates of colorectal cancer and UVB estimate adjusting for urbanization, skin pigmentation, smoking, animal consumption, per capita GDP, and life expectancy. Statistical analysis was followed by geospatial visualization by producing choropleth maps.Results: The inverse relationship between UVB exposure and CRC crude rates was stronger in older age groups at the country level. Quadratic curve fitting was preferred, and these models were statistically significant for all age groups. The inverse association between crude incidence rates of CRC and UVB exposure was statistically significant for age groups above 45 years, after controlling for covariates.Conclusion: The age-dependent inverse association between UVB exposure and incidence of colorectal cancer exhibits a greater effect size among older age groups in global analyses. Studying the effect of chronic vitamin D deficiency on colorectal cancer etiology will help in understanding the necessity for population wide screening programs for vitamin D deficiency, especially in regions with inadequate UVB exposure. Further studies are required to assess the need for adequate public health programs such as selective supplementation and food fortification.
The clinical analysis of endoscopic pancreaticobiliary separation in the treatment of occult pancreaticobiliary reflux
Authors: Gang Zhao , Cheng Zhang , Hao Cai , An Xu An , Dong Li Hai , Qi He Chuan , Aliou GARBA SEYDOU , Long Yang Yu
Published: April 2020

Objective To investigate the aetiology of occult pancreaticobiliary reflux (OPBR) and the curative effect of EST in patients with cholecystolithiasis. Methods The clinical data of 47 OPBR patients with cholecystolithiasis from October 2013 to October 2016 were analyzed retrospectively.Results The average gallbladder bile amylase (GBA) of 47 patients was 864 ± 575 U/L. Forty patients underwent endoscopic retrograde cholangiopancreatography (ERCP), among which 26 patients were diagnosed with papillitis, 16 patients with peripapillary diverticulum, 14 patients with nipple overlength, five patients with nipple atrophy, three patients with ampullary calculi and two patients with papillary tumour. Thirty-three patients underwent endoscopic sphincterotomy (EST), after the operation, 16 patients reexamined GBA, in which 15 patients had normal GBA, and the difference of GBA was statistically significant (1161 ± 764 U/L vs 47 ± 17 U/L, t=5.641, P<0.05). After following up of 1 to 4 years, 27 patients without cholecystectomy who underwent EST had no recurrence of calculus, and in 9 patients who did not undergo EST, two patients had a recurrence of calculus. There was a significant difference in the recurrence rate of calculus (χ2=21.340, P<0.05). Conclusion Pancreaticobiliary junction disease is an essential cause of OPBR and cholecystolithiasis formation. EST can reduce the retention of pancreatic reflux juice both in gallbladder and bile duct and can reduce the recurrence rate of cholecystolithiasis after choledochoscopic lithotomy.
The miRNA Complexes Against Coronaviruses COVID-19, SARS-CoV, And MERS-CoV
Authors: Rakhmetullina Aizhan , Ivashchenko Anatoliy , Akimniyazova Aigul , Aisina Dana , Pyrkova Anna
Published: April 2020

Background: In the past twenty years humankind has effected from infection caused by SARS-CoV (severe acute respiratory syndrome), MERS-CoV (Middle East respiratory syndrome) and COVID-19 coronaviruses, which have caused significant harm to human health and resulted in high mortality. The possibility of using miRNA (mRNA-inhibiting RNA) to inhibit infections caused by the coronaviruses COVID-19, SARS-CoV, and MERS-CoV has been shown. Methods: The MirTarget program determines the following characteristics of interaction between miRNAs and messenger RNAs (mRNAs): the start of the miRNA binding site on the mRNA; the locations of the miRNA binding sites in the 3'-untranslated region (3'UTR), 5'-untranslated region (5'UTR), or coding sequence (CDS); the interaction free energy (∆G, kJ/mole); and nucleotide interaction schemes between miRNAs and mRNAs. Results: Using bioinformatics approaches, completely complementary miRNA (cc-miRNA) complexes were predicted to be able to bind and inhibit the translation of coronavirus proteins and the replication of COVID-19, SARS-CoV, and MERS-CoV genomes. For complexes of seven completely complementary miRNA of COVID-19 (cc-miRc), seven completely complementary miRNA of SARS-CoV (cc-miRs), and eight completely complementary miRNA of MERS-CoV (cc-miRm), the interactions with the RNA genomes (gRNAs) of the corresponding coronaviruses was evaluated. The free energy of the interactions of cc-miRNAs with binding sites was significantly higher than the free energy of the interactions with other regions in gRNA, which ensures high selectivity of the binding of cc-miRNAs. Weak binding of cc-miRNAs to the mRNAs of 17508 human genes was shown, which suggests the absence of side effects of the cc-miRNAs in humans. A feature of this method is the simultaneous inhibition of translation and replication by several cc-miRNAs binding from the 5' end to the 3' end of gRNA. Conclusion: The use of several cc-miRNAs to suppress infections allows each of them to be used at a lower concentration to avoid side effects when one cc-miRNA is introduced into humans at a high concentration.
Gamifying Parenting Education Using an App Developed for Pacific and Other New Zealand Families (Play Kindly): Qualitative Study
Authors: Mairs Rebecca A , Bekker Marthinus J , Patolo Tony , Hopkins Sarah A , Cowley-Malcolm Esther T , Perese Lana M , Sundborn Gerhard B , Merry Sally N
Published: April 2020

Background

Play Kindly is a gamified animated app designed to address common behavioral problems in childhood. The interface is designed to appeal to Pacific people, a population group with a higher risk of developing clinically significant behavioral problems than most other ethnic groups in New Zealand.

Objective

The aim of this study is to explore the opinions of parents and professionals about the acceptability, usability, and content of Play Kindly.

Methods

We used qualitative and Pacific and Māori research methodologies. A total of five focus groups with 45 parents and 12 individual interviews with professionals were conducted. The five focus groups consisted of 2 pan-Pacific groups, 1 Māori group, 1 open group, and 1 group of young Pacific adults or prospective parents. The professionals were from a range of disciplines, and the majority had expertise in early childhood, parenting interventions, or research in this field.

Results

Play Kindly appealed to both parents and professionals. Participants related to the scenarios, which were created in collaboration with a playwright and animator. Although most participants liked the Pacific feel, there was some disagreement about how culturally specific the app should be. A range of issues with usability and gamification techniques were highlighted, likely attributed to the low budget and lack of initial co-design with parents as well as professionals with specific expertise in parenting. A number of parents and professionals felt that the parenting strategies were overly simplified and did not take into account the context in which the behavior occurred. Professionals suggested narrowing the focus of the app to deliver two important parenting messages: playing with your child and positively reinforcing desired behaviors.

Conclusions

Play Kindly is the first culturally adapted parenting app of its kind designed for Pacific parents and other New Zealanders with children 2-5 years of age. This app has potential in Pacific communities where there are limited culturally specific parenting resources. The results of this study will guide improvements of the app prior to testing it in an open trial.
JOINT ESTIMATION OF STATES AND PARAMETERS OF LINEAR SYSTEMS WITH PARAMETER FAULTS UNDER NON-GAUSSIAN NOISES
Authors: Stojanović Vladimir , Pršić Dragan , Dubonjić Ljubiša
Published: April 2020

Joint estimation of states and time-varying parameters of linear state space models is of practical importance for the fault diagnosis and fault tolerant control. Previous works on this topic consider the joint estimation in the Gaussian noise environment, but not in the presence of outliers. The known fact is that the measurements have inconsistent observations with the largest part of the observation population (outliers). They can significantly make worse the properties of linearly recursive algorithms which are designed to work in the presence of Gaussian noises. This paper proposes the strategy of the joint parameter-state robust estimation of linear state space models in the presence of non-Gaussian noises. The case of parameter-dependent matrices is considered. Because of its good features in robust filtering, the extended Masreliez-Martin filter represents a cornerstone for realization of the robust algorithms for joint state-parameter estimation of linear time-varying stochastic systems in the presence of non-Gaussian noises. The good features of the proposed robust algorithm for joint estimation of linear time-varying stochastic systems are illustrated by intensive simulations.
Paulo Freire, mais do que nunca: uma biografia filosófica
Authors: Silva e Silva José Walter , Mafra Jason Ferreira
Published: April 2020

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MENGEJAWANTAHKAN NILAI TASAWUF DALAM DIRI GURU/PENDIDIK
Authors: Maulida W Truli
Published: April 2020

MENGEJAWANTAHKAN NILAITASAWUF DALAM DIRIGURU/PENDIDIKTruli Maulida W *)MTs MuhammadiyahMalang dan MahasiswaPascasarjana UIN MalangABSTRACTLead people in the right direction is not enough to make the formalactivities of the task as a teacher in the law, but needed no otheractivities that are spiritual. Therefore it is important to have themanifestation of Sufism values in the teachers / educators. Rests ofthe above background, issues to be discussed in the paper is, how toembody the values of Sufism in the teacher / educator in the task ofrunning his noble?. Objectives to be achieved in this discussion is todescribe the embodiment of the value-the value of Sufism in teacher/ educator in the noble task. This discussion uses descriptive methodbecause it was limited to providing a description of a phenomenonbased on research by library (Library Research).Keyword:Guru, Tasawuf, Sufi
PENDIDIKAN KARAKTER MELALUI PEMBELAJARAN PAI BERBASIS KONTEKSTUAL
Authors: Budianto Erik
Published: April 2020

PENDIDIKAN KARAKTER MELALUIPEMBELAJARAN PAI BERBASISKONTEKSTUALErik Budianto *)Magister Pendidikan IslamUMMABSTRACTThe condition of education in our country so far is still very alarming. Our education hasnot been able to shape the character of the students, because education is still focused oncognitive aspects, Islamic religious education is no exception. So the lifestyle ofmaterialism, consumerism, and hedonism and moral degadensi happening in society,especially among adolescents has not been able to overcome. Therefore, this paper aimsto describe one effort that can be done in shaping the character of students, namelythrough the study of contextual-based Islamic religious education. Islamic religiouseducation contextual-based learning is an attempt to alter the character of cognitiveknowledge into "meaning" and "value." This has been a fundamental principle in theformation of character, which is building the "meaning" and "value" in the educationprocessKata Kunci :Pendidikan Karakter, Pendidikan AgamaIslam, Kontekstual
KURIKULUM PENDIDIKAN INDONESIA: ANTARA ADAB DAN INTELEKTUAL
Authors: Firmansyah M. Feri
Published: April 2020

Education Indonesia is launching Character Education, which is education that aims to build the character of students to become civilized intellectuals. But it becomes an anomaly because in reality the students sometimes underestimate their teacher. This means that here Indonesia Education has not found the right formula for this concept. Different from the concept of Islamic Education, where Islamic Education is more comprehensive in shaping the character of students, namely through strengthening the spirit of their faith and adab. In other words, in the historical literature of the Islamic Education curriculum, there are two, namely the Curriculum of Faith and the Koran. After Faith and Al-Quran strong students then they recognize applied sciences, such as science, Social Sciences, and so forth.
Redução do desenvolvimento inicial de mudas de Aspidosperma australe (Müll) Arg produzidas em substratos com diferentes proporções de pó de rocha basáltica
Authors: Amaral Nilmar Borges do , Padilha Matheus Santin , Kraft Elston , Belotti Alencar , Baretta Carolina Riviera Duarte Maluche
Published: April 2020

Uma forma de aumentar a fertilidade dos substratos para produção de mudas florestais é a utilização de fertilizantes alternativos, como a rocha basáltica finamente moída. O trabalho objetivou avaliar o efeito do uso do pó de rocha basáltica no desenvolvimento de mudas de Aspidosperma australe. O experimento foi conduzido em delineamento de blocos casualizados com quatro repetições testando cinco combinações de pó de rocha basáltica (0; 10; 15; 20 e 25%) e solo (100; 90; 85; 80 e 75%) como substrato. Decorridos 120 dias após a semeadura foram avaliados: altura de planta, diâmetro de coleto, massa seca de parte aérea e raiz, relação altura de parte aérea e diâmetro do coleto; e determinadas as relações altura de parte aérea/massa seca de parte aérea, massa seca da parte aérea/massa seca de raiz, e calculado o índice de qualidade de Dickson. O uso do pó de rocha basáltica afetou negativamente o crescimento das mudas de A. australe diminuindo o seu crescimento de parte aérea e raiz. O tratamento controle proporcionou a produção de mudas de maior qualidade baseado na avaliação de características fenotípicas - como a maior altura de parte aérea e, medidas do vigor - como o maior diâmetro de coleto e maior valor do Índice de qualidade de Dickson.
La polémica entre Leibniz y Johann Bernoulli acerca de los infinitesimales (¿Es Johann Bernoulli un precursor de Cantor?)
Authors: Joven Álvarez Fernando
Published: April 2020

RESUMENA finales del siglo XVIII existe un intercambio de cartas entre Leibniz y Johann Bernoulli en el que tratan la posible existencia de una referencia para los infinitesimales. Ambos tratan de justificar el cálculo desde posiciones contrapuestas acerca de la realidad de los infinitesimales. Bernoulli defiende vehementemente la existencia del infinito actual mientras que Leibniz lo niega. Algunas de las afirmaciones de Johann Bernoulli podrían leerse hoy en día como predecesoras de las posturas de Cantor.PALABRAS CLAVEINFINITESIMALES-CANTOR-LEIBNIZ-BERNOULLIABSTRACTAt the end of 17th century, Leibniz and Johann Bernoulli held an Exchange of correspondence concerning the possibility of a reference for the infinitesimals. Both attempted to justify the calculus from opposed points of view about the reality of infinitesimals. Bernoulli insists in the existence of the actual infinite, White Leinniz dinies it. Some of Johann Bernoulli´s positions could be read today as precedents of Cantor´s ideas.KEYWORDSINFINITESIMALS-CANTOR-LEIBNIZ-BERNOULLI
Filosofía como búsqueda de la justicia (A propósito de M. Horkheimer, T. W. Adorno y H. Marcuse)
Authors: Panea Márquez José M.
Published: April 2020

RESUMENEl presente artículo aborda la pregunta por el resultado por el sentido y responsabilidad de la filosofía en la búsqueda de la justicia. Para ello, analiza las reflexiones de la Escuela de Frankfurt en torno a la filsoofía, su compromiso crítico, y más en concreto su visión de la educación en la búsqueda de un mundo más racional y humano.PALABRAS CLAVEESCUELA DE FRANKFURT-JUSTICIA-EDUCACIÓNABTRACTThis paper addresses the question about the meaning and responsibility of philosophy in the search for justice. Is studies the work of the Frankfurt School, the critical compromise os its members and, more specifically, their idea of education in the search for a world more rational and human.KEYWORDSFRANKFURT SCHOOL-JUSTICE-EDUCATION
El concepto de superación en Ortega
Authors: González-Sandoval Buedo José
Published: April 2020

RESUMENPartiendo de la admisión del carácter problemático de la obra orteguiana, así como de considerar el concepto de "superación" como un problema "nodal" (cuestiones aparentemente sin importancia, pero una vez solucionadas irradian luz sobre otros temas más relevantes del sistema raciovitalista), esta nota llega a la conclusión de que Ortega interpreta y usa dicho término en el sentido de la Aufhebung de la dialéctica de Hegel, después de indicar las dos maneras de entender "superación", nietzscheana de "trascender" o hegeliana de "conservar".PALABRAS CLAVEORTEGA-HEGEL-DIALÉCTICAABTRACTAssuming the problematic character of Ortega´s work, and taking the concept of overcoming ("superción") as a "nodal" problem (whose solution sheds light over other areas of Ortega´s philosophy), this note will argue that Ortega interprets that term under the meaning of Hegel´s Aufhebung. It will remark that "superación" is used by Ortega in a sense both Nietzschean and Hegelian.KEYWORDSORTEGA-HEGEL-DIALECTICS
El patriacado y la estructura social de la vida cotidiana
Authors: Postigo Asenjo Marta
Published: April 2020

RESUMENEl sistema patriarcal no afecta exclusivamente al poder político y judicial, sino que afecta a la estructura interna de la sociedad, la identidad y las formas de vida de los individuos que en ella viven. Para comprender mejor como condiciona el sistema patriarcal las formas de vida y la visión que tienen los individuos de la realidad social, hemos de analizar el modo en que se extiende al orden institucional y lo determina mediante "tipificaciones" de hechos y de personas y mediante roles concretos, esteoreotipaciones sexiuales que obstaculizan el acceso a la esfera pública de la mujer, así como su reinserción en el mercado laboral, en suma, todo aquello que afecta al conocimiento común que comparten los miembros de una comunidad. El cambio hacia una mayor igualdad y una real democracia paritaria y compartida no es posible sin una paulatina educación y concienciación de la sociedad en su conjunto.PALABRAS CLAVEPATRIARCADO-TIPIFICACIÓN SOCIAL-IGUALDAD DE GÉNEROABSTRACTPatriarchalism is not only present in politics and the judicial system. It also affects the internal structure of society, above all the life and identitý of individuals. To understand better how it conditions their ways of life and the vision the individuals have of social reality, we should study how patriarchalism r3eaches the system of institutions and how this becomes determined by "typifications" of facts and people, and by certain roles or sexual stereotypes that hinder the access of women both to the public sphere and to tha labor market. It sum, everything that concerns the common knowledge that the members of a community share. The move towards more equality and towards a more egalitarian democracy heavily depends on the spread of civic education to the entire society.KEYWORDSPATRIARCHALISM-SOCIAL TYPIFICATION-GENDER EQUALITY
Traducción Crítica. F. Nietzsche, Póstumos del joven Nietzsche (1870-1874) acerca de la idea de Bildung
Authors: Esteban Anguita José E.
Published: April 2020

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Introducción
Authors: Martínez-Freire Pascual F. , Benítez Rochel Rafaela , Burrieza Muñiz Alfredo , Caño González Antonio , Luque Vilaseca Juan L. , Missa Jean-Nöel , Mora Mérida Juan A. , Nepomuceno Fernández Ángel , Pérez de la Cruz José L. , Ramos Jiménez Gonzálo , Rodríguez Santos José M. , Rodríguez Serón Alicia , Torres Monreal Santiago
Published: April 2020

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Reseña
Authors: . .
Published: April 2020

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It Is Time to Put Special Tests for Rotator Cuff–Related Shoulder Pain out to Pasture
Authors: Salamh Paul , Lewis Jeremy
Published: April 2020

Synopsis

“Special tests” for rotator cuff–related shoulder pain (RCRSP) have passed their sell-by date. In this Viewpoint, we outline fundamental flaws in the validity of these tests and their proposed ability to accurately identify a pathoanatomical source of pain. The potential harm of these special tests comes in conjunction with imaging findings that are utilized to inform a structural diagnosis or recommend invasive procedures. We offer recommendations for performing a clinical interview and physical examination for people with RCRSP that does not include shoulder orthopaedic tests. J Orthop Sports Phys Ther 2020;50(5):222–225. doi:10.2519/jospt.2020.0606
Influência da fisioterapia na reabilitação de pacientes submetidos à drenagem torácica em um hospital de urgência e emergência da amazônia legal
Authors: Duarte Maycon Pelosato , Rosa Ledne Luiz Dalla , Pinheiro Erick Marques , Alves Isabela Kerber , Santos Aline Arcari , Andrade Állef Diego Bonfim de , Bonet Leiri , Azevedo Marcos Vinícius de , Diniz Welton Alves
Published: April 2020

Objetivo: Analisar a influência da fisioterapia na reabilitação de pacientes submetidos à drenagem torácica pós-trauma de tórax atendidos em um Hospital de Urgência e Emergência da Amazônia Legal. Métodos: Trata-se de um estudo descritivo, prospectivo, através de uma pesquisa documental de levantamento de dados em um Hospital de Urgência e Emergência da Amazônia Legal, com base na coleta de dados dos prontuários de pacientes que realizaram drenagem torácica pós-trauma de tórax e submetidos à intervenção fisioterapêutica no período de março a setembro de 2018. Resultados: A predominância dos pacientes admitidos com trauma torácico neste estudo é da população adulta jovem, do sexo masculino e vítimas de acidente automobilístico. Notou-se estatisticamente que o tempo de internação hospitalar e o tratamento fisioterapêutico são diretamente proporcionais para uma boa evolução clínica do paciente, pois a reabilitação pulmonar reduziu os índices de complicações pós-drenagem torácica, houve melhora da capacidade pulmonar e tempo de internação reduzido. Conclusão: Dentre os principais objetivos da reabilitação pulmonar notou-se a redução dos índices de complicações pós-drenagem torácica, com melhora da capacidade funcional e da qualidade de vida. Contudo observou-se estatisticamente a correlação entre o tempo de internação e o tratamento fisioterapêutico, que são diretamente proporcionais.
PENGARUH STRUKTUR MODAL DAN PERTUMBUHAN TERHADAP PROFITABILITAS DAN NILAI PERUSAHAAN (STUDI KASUS PADA PERUSAHAAN OTOMOTIF YANG TERCATAT DI BURSA EFEK INDONESIA)
Authors: Harusi Muhammad Khakani , Ali Muhammad , Sobarsyah Muhammad
Published: April 2020

Persaingan yang ketat dalam dunia usaha mendorong setiap perusahaan untuk meningkatkan kinerjanya agar tujuan perusahaan dapat tercapai. Perusahaan yang telah go public akan senantiasa berusaha untuk meningkatkan nilai perusahaan, melalui struktur modal, pertumbuhan serta profitabilitas. Penelitian ini bertujuan untuk mengetahui dan menganalisis : pengaruh struktur modal dan pertumbuhan perusahaan terhadap profitabilitas. Pengaruh struktur modal dan pertumbuhan perusahaan terhadap nilai perusahaan. Pengaruh profitabilitas terhadap nilai perusahaan, pengaruh struktur modal terhadap nilai perusahaan dimediasi oleh profitabilitas, serta untuk mengetahui dan menganalisis pengaruh pertumbuhan perusahaan terhadap nilai perusahaan dimediasi oleh profitabilitas. Penelitian ini menggunakan pendekatan kuantitatif. Sedangkan teknik pengumpulan data dengan menggunakan observasi, dan dokumentasi. Teknik analisis data yang digunakan adalah analisis deskriptif,  uji  asumsi  klasik,  analisis jalur. Hasil analisis dalam penelitian ini yang menunjukkan bahwa struktur modal (DER) berpengaruh negatif dan signifikan terhadap profitabilitas. Pertumbuhan perusahaan berpengaruh positif dan signifikan terhadap profitabilitas (ROA). Struktur modal berpengaruh negatif terhadap nilai perusahaan. Pertumbuhan perusahaan memberikan pengaruh yang bermakna dalam meningkatkan nilai perusahaan. Profitabilitas (ROA) yang tinggi akan memberikan pengaruh dalam meningkatkan nilai perusahaan. Hasil uji mediasi menunjukkan bahwa profitabilitas dapat memediasi pengaruh struktur modal (DER) terhadap nilai perusahaan. Hal ini dapat dilihat bahwa struktur modal (DER) mempengaruhi profitabilitas (ROA) sehingga berimplikasi terhadap rendahnya nilai perusahaan (PER). Hasil uji mediasi yang menunjukkan bahwa profitabilitas dapat memiliki pengaruh pertumbuhan perusahaan terhadap nilai perusahaan, yang artinya pertumbuhan perusahaan mempengaruhi peningkatan profitabilitas (ROA) yang berimplikasi dalam meningkatkan nilai perusahaan (DER).