bluuebunny/crossref_metadata_2025 huggingface dataset:
Inferring and evaluating satellite-based constraints on NOx emissions estimates in air quality simulations
Authors: East James D. , Henderson Barron H. , Napelenok Sergey L. , Koplitz Shannon N. , Sarwar Golam , Gilliam Robert , Lenzen Allen , Tong Daniel Q. , Pierce R. Bradley , Garcia-Menendez Fernando
Published: July 2022

Abstract. Satellite observations of tropospheric NO2 columns can provide top-down observational constraints on emissions estimates of nitrogen oxides (NOx). Mass-balance based methods are often applied for this purpose, but do not isolate near-surface emissions from those aloft, such as lightning emissions. Here, we introduce an inverse modeling framework that couples satellite chemical data assimilation to a chemical transport model and infers satellite-constrained emissions totals using the iterative finite-difference mass-balance method. The approach improves the finite-difference mass-balance inversion by isolating the near-surface emissions increment. We apply the framework to estimate lightning and anthropogenic NOx emissions over the Northern Hemisphere. Using overlapping observations from the Ozone Monitoring Instrument (OMI) and the Tropospheric Monitoring Instrument (TROPOMI), we compare NOx emissions inferences from these satellite instruments, as well as the impacts of emissions changes on modeled NO2 and O3. OMI inferences of anthropogenic emissions consistently lead to larger emissions than TROPOMI inferences, attributed to a low bias in TROPOMI NO2 retrievals. Updated lightning NOx emissions from either satellite improve the chemical transport model’s low tropospheric O3 bias. Combined lightning and anthropogenic updates inferred from satellite observations can improve the model’s ability to represent background and ground-level O3 concentrations, an ongoing policy consideration in the U.S. as domestic and international emissions control strategies evolve.
Earthquake forecasting model for Albania: the area source model and the smoothing model
Authors: Xhafaj Edlira , Chan Chung-Han , Ma Kuo-Fong
Published: July 2022

Abstract. We proposed earthquake forecasting models for Albania, one of the most seismogenic regions in Europe, to give an overview of seismic activity by implementing area source and smoothing approaches. The earthquake catalog was firstly declustered to remove foreshocks and aftershocks when they are within the derived distance- and time-windows of mainshocks. Considering catalog completeness, the events with M≥4.0 during the period of 1960–2006 were implemented for the forecast model learning. The forecasting is implemented into an area source model that includes 20 sub-regions and a smoothing model with a cell size of 0.2° x 0.2° to forecast the seismicity in Albania. Both models show high seismic rate along the western coastline and at the southern part of the study area, consistent with previous studies which discussed seismicity in the area and currently active regions. To further validate the forecast performance from the two models, we introduced the Molchan diagram to quantify the correlation between models and observations. The Molchan diagram suggests that both models are significantly better than a random distribution, confirming their forecasting abilities. Our results provide crucial information for subsequent research on the seismic activity, such as probabilistic seismic hazard assessment.
New constraints on the tectonic evolution by subduction of the Bangong Co-Nujiang Tethys Oceanic Basin: Insights from magnetic fabric and U-Pb dating of detrital zircon during the Late Jurassic to Early Cretaceous
Authors: Chen Qinglong , Cheng Xin , Huo Feifei , Zhou Yanan , Jiang Nan , Wei Bitian , Wang Baofeng , Xu Pengxiang , Zhang Dongmeng , Xing Longyun , Li Teng , Liu Feifan , Wu Jingyue , Wang Jiawei , Wu Hanning
Published: July 2022

Abstract. The subduction process between the Bangong Co-Nujiang Tethys Oceanic Basin and the South Qiangtang Block is one of the key issues in the study of the Tethys domain. In order to clarify the evolution process and achieve tectonic constraints, the clastic rock and limestone in the northern margin of the Lhasa block and the southern Qiangtang block were studied in detail through the study of magnetic fabric and zircon U-Pb dating. The results show that the depositional age of the Shamuluo Formation is 131–95 Ma, belonging to the Late Jurassic-Early Cretaceous; the Sowa Formation is earlier (163.5–157.3 Ma), belonging to the Late Jurassic. The detrital provenances of the Shamuluo and Suowa Formations are mainly from the magmatic arc of the Lhasa block and the cyclic orogenic belt of the South Qiangtang block. The fabrics of sandstones in the Shamuluo Formation and some sandstones in the Suowa Formation belong to sedimentary magnetic fabrics related to paleocurrent; the limestone and other sandstones of the Sowa Formation are subject to stress and deformation, and belong to the strain fabric related to the structure. A comprehensive study of detrital zircon U-Pb geochronology, magnetic fabric and petrography shows that the Bangong Co-Nujiang ocean basin is affected by plate fragmentation, and there is a north-south two-way subduction. The southward subduction changes in polarity at 163.5–157.3 Ma and begins the northward subduction. At 145 Ma, the Bangong Co-Nujiang Tethys Ocean closed, but the central remnant of Bangong Co-Nujiang Oceanic Basin continued to subduct until 131–102.9 Ma.
Classification and mapping of European fuels using a hierarchical-multipurpose fuel classification system
Authors: Aragoneses Elena , García Mariano , Salis Michele , Ribeiro Luís M. , Chuvieco Emilio
Published: July 2022

Abstract. Accurate and spatially explicit information on forest fuels becomes essential to designing an integrated fire risk management strategy, as fuel characteristics are critical for fire danger estimation, fire propagation and emissions modelling, among other aspects. This paper presents the conceptual development of a new fuel classification system that can be adapted to different spatial scales and used for different purposes. The resulting fuel classification system encompasses a total of 85 fuel types, that can be grouped into six main fuel categories (forest, shrubland, grassland, cropland, wet and peat/semi-peat land and urban), plus a nonfuel category. For the forest cover, fuel types include two vertical strata, overstory and understory, to account for both surface and crown fires. Based on this classification system, a European fuel map at 1 km resolution, was developed within the framework of the FirEUrisk project, which aims to create a European integrated strategy for fire danger assessment, reduction, and adaptation. Fuels were mapped using land cover and biogeographic datasets, as well as bioclimatic modelling, in a Geographic Information System environment. The first assessment of this map was performed by comparing it to high-resolution data, including LUCAS (Land Use and Coverage Area frame Survey) data, Google Earth images, Google Street View images, and the GlobeLand30 map. This validation exercise provided an overall accuracy of 88 % for the main fuel types, and 81 % for all mapped fuel types. Finally, to facilitate the use of this fuel dataset in fire behaviour modelling, a first assignment of fuel parameters to each fuel type was performed by developing a crosswalk to the standard fuel models defined by Scott and Burgan (FBFM, Fire Behavior Fuel Models), considering European climate diversity.
STUDI KERUSAKAN PRASARANA JALAN DI PASAR SENTRAL KALIBOBO KABUPATEN NABIRE TERHADAP AKTIVITAS EKONOMI MASYARAKAT
Authors: Rorroong D Semuel
Published: July 2022

Damage  to  roads  will  cause  many  losses  to  community  activities  or  activities,  especially  economic activities that can be felt by users directly and also economic actors, in this case local market traders.Similar problems can be seen in road conditions in Kalibobo Central Market, Nabire Regency, Province Papua, in almost the last one period, the road at Kalibobo Central Market, Nabire Regency, is very concerned about. Many people have complained to the local Regency Government to pay attention to this road but until now it has not been well realized.  The objectives of this study are: "Knowing the effects of damage to road infrastructure at the Kalibobo Central Market on the Economic Activities of the Nabire Regency Community." The data analysis method used by the writer is descriptive qualitative with data collection techniques used, namely observation and interviews, the results obtained are the effect of road damage on economic activity, among others: Inadequate road class, vehicle intensity with large loads, parking  area that  is not  regular,  Lack of Government Attention.  Therefore it is necessary  to  have  a thorough  road  paving  by the Nabire Regency  government so  that economic activity in the Kalibobo central market can work well.
The Effectiveness of Geoeduvid Website Learning Media on Spatial Intelligence Natural Disaster Mitigation in SMA
Authors: Rizaldy David , . Juhadi , Aji Ananto
Published: July 2022

Education is one of the benchmarks in achieving the progress of a country. Learning media that has used the latest technology is a website. The media designed in this research is the Geoeduvid Website for learning geography in high school. The formulation of the problem in the research is how the effectiveness of the Geoeduvid Website learning media for disaster mitigation spatial intelligence in high school. The purpose of the study was to determine the effectiveness of the Geoeduvid Website learning media for spatial intelligence of disaster mitigation in high school. The population used is all SMA and MA in Sragen. The research sample used was SMA Walisongo Karangmalang and MA Nurul Huda Gondang. The research sample technique used is probability sampling with cluster sampling type. Data collection techniques with tests, questionnaires, and documentation. Data analysis technique with quantitative descriptive.

Keywords: Geoeduvid, media, website. .
Marketing Channel Analysis of Oil Palm Fresh Fruit Bunches in Lubuk Barumun District, Padang Lawas Regency
Authors: Alvian MHD. , P Wibowo Rulianda , Negara Lubis Satia
Published: July 2022

The purpose of the research is to find out marketing channel analysis of oil palm fresh fruit bunches in Lubuk Barumun District, Padang Lawas Regency. The research was conducted in Lubuk Barumun District in Padang Lawas Regency, North Sumatra Province with the consideration that Padang Lawas Regency has potential in developing oil palm plantation areas. The research was carried out from January to February 2021. The sample collection of producer farmers was carried out by purposive sampling with the sample criteria being independent oil palm farmers. From the population of oil palm farmers in Padang Lawas Regency as many as 297 people, a sample of 10 percent was taken, namely 30 farmer respondents. Quantitative analysis is used to determine the Hirschman Herfindahl index on market structure, market behavior based on the price relationship between two markets at the same level and the magnitude of market performance based on marketing margin analysis, profit margin ratio, farmer's share, cost share, and profit share. The results showed that, the number of oil palm farmers is large while the number of sellers or intermediaries is only a few so that the marketing system for fresh fruit bunches of oil palm tends to be imperfect competition because there are many sellers but few buyers (oligopsony). Analysis of the Hirschman Herfindahl index, it is known that the market structure of oil palm fresh fruit bunches in Lubuk Barumun District, Padang Lawas Regency tends to lead to an imperfect competition market (oligopsony) which causes the bargaining position of oil palm fresh fruit bunches farmers to be in poor condition weak, namely as a price taker. The efficiency of an already efficient marketing channel is the one that shows the smallest value of marketing efficiency, namely in channel III (Ep < 5% efficient). Marketing channels I and II have not been efficient (Ep > 5% inefficient).

Keywords: Marketing Channel, Oil Palm, Fresh Fruit Bunches .
The Influence of Entrepreneurial Competency, Learning Orientation, and Entrepreneurial Motivation on SME Performance
Authors: Nururly Santi , Asmawi Moch. , . Hamidah
Published: July 2022

This study aims to investigate the influence of entrepreneurial competency, learning orientation, and entrepreneurial motivation on SME performance. The study was conducted using a quantitative method with a sample of 200 SMEs from food and beverage industries have been established for more than 3 years and where chosen classified random sampling. The results show that entrepreneurial competency, learning orientation, and entrepreneurial motivation affect SMEs performance. In this research, entrepreneurial motivation shows the strongest influence on SME performance compared to entrepreneurial competency and learning orientation.

Keywords: entrepreneurial competency; learning orientation; entrepreneurial motivation; SME performance.
The Implementation of National Community Program-Based Water Supply and Sanitation
Authors: Nainggolan Indra , Badaruddin Badaruddin , Irmayani Tengku
Published: July 2022

This research aims to discover the implementation of the National Community Program-Based Drinking Water and Sanitation (Pamsimas) in Siempat Rube District, Pakpak Bharat Regency, North Sumatra Province. The focus of this research is to determine the extent of the success from its program implementation. This research was conducted during 2020 to 2021. This research used a qualitative method through the data used are primary data and secondary data. The instrument that used in this research based on George C. Edward III Implementation Model. The Informants that used in this research are the informants who directly involved in the implementation of the Pamsimas Program in Siempat Rube District, Pakpak Bharat Regency. The results from this research shows that the implementation in general has been conducted quite well. However, in terms of community participation in this program realization, there are still a few obstacles namely the lack of participation from the entire community in the planning of Pamsimas program, a lack of interest in the level of management Village such as KKM, SATLAK and BP-SPAM, so those obstacles that have been determined by the program,which is participation or obligations in the form of In Cash (Money) and In Kind of (Materials and Services).

Keywords: Implementation of Policy, Pamsimas, Drinking Water.
Analysis of the Implementation of Enterprise Resources Plan (ERP) on Company Performance (Case Study of PT Sapta Sentosa Jaya Abadi)
Authors: Sitanggang Badia Hardiknas , Sadalia Isfenti , . Iskandarmuda
Published: July 2022

PT Sapta Sentosa Jaya Abadi is a plantation company located in four different provinces. The company operates the oil palm business (cultivation and processing factory). The company was founded in 2002. Previously the company relied on manual operation in every of their administration, realizing the importance of building an information system based on Enterprise Resources Plan (ERP), the company collaborated with third parties s developed ERP which they called Go Palms. Indeed, Go Palm makes work easier and ultimately improves the company's performance, but performance data from 2016 to 2020, actually shows a downward trend. Lack of socialisation, makes employees as users find it difficult both in adapting and using information systems in their work to find out how the role of information systems drives performance, the authors researched the role of ERP on company performance through Quality of Information Systems. The research method used is quantitative with the Regression Analysis Approach as a data processing method. The research was conducted on all 10ERP users. The results show that: 1) there is a simultaneous influence of Go Palm's Information System Quality on the Company's Performance; 2) There is a partial effect of Product Operation on Company Performance; 3) there is no partial effect of Product Revision on Company Performance, and; 4) There is a partial effect of Product Transition on Company Performance at PT. Sapta Sentosa Jaya Abadi. The suggestion in this study is that management needs to carry out socialization and training related to the use of the ERP system, so the employees know why they need to do work using an ERP information system and also the benefits they can get.

Keywords: Enterprise Resources Plan (ERP), Performance Appraisal Management, Quality of Information System.
Development of Professional Skills of Bachelors of Musical Art in the Context of Dual Education
Authors: Barytska Оleksandra A. , Turovska Natalia A. , Budim Liudmyla V. , Tsaruk Svitlana M. , Hutsal Rosina S.
Published: July 2022

The relevance of the study is conditioned by the need to investigate the interaction of the following aspects: studying the curriculum in a higher educational institution by listening to lecture courses, preparing for the session and passing it, implementing and further developing existing professional skills directly in the work. The purpose of this research paper is to reveal the ways of developing and improving professional skills of bachelors of musical art in the context of dual education, combining educational (theoretical) and labour (practical) activities at the same time. The research materials are data from monitoring the quality of education acquired in conditions of duality, and information on the principles of combining these aspects at the same time. Methods of studying the problem – collecting and systematising sources devoted to it, deducing the categories that make up the core of the analysed issue, and drawing up a unified picture of the development of professional skills of students of musical educational institutions in the conditions of dual education. As for the study results, they contain information about the internal content and nature of such a phenomenon as duality in the acquisition of a profession. The prospects of this phenomenon, its uniqueness, significance, and opportunities provided to future specialists are also outlined. The results of the study can be used by teachers to improve the professional training of music students, and by researchers and students to find ways to improve the interaction between music education institutions and organisations that offer jobs
Detecção molecular de Leishmania em flebótomos de um município de Alagoas
Authors: Bezerra Aryel José Alves , Silva Thiago Emanuel Ribeiro , Bassi Letícia Anderson
Published: July 2022

Introdução: Leishmanioses são doenças parasitárias transmitidas por vetores, causadas por espécies de protozoários do gênero Leishmania, são transmitidas por fêmeas de flebotomíneos entre mamíferos hospedeiros. É uma importante zoonose parasitária contagiosa onde o seu agente transmissor encontra-se em ambientes urbanos e rurais, no qual, afetam animais domésticos e silvestres, podendo ser transmitida ao homem. No estado de Alagoas não há informações recentes sobre presença de flebótomos em região endêmica, ou estudos moleculares destes mosquitos. Objetivo: Assim, o objetivo da pesquisa é realizar a busca ativa por flebótomos no município de Rio Largo (AL) e avaliar por detecção molecular a infecção por Leishmania para assim categorizar como uma região endêmica de leishmaniose. Metodologia: Os flebótomos são capturados com o auxílio de armadilhas CDC luminosas e depois armazenados em copos entomológicos para o transporte até o laboratório. É realizada a identificação taxonômica desses mosquitos com o microscópio óptico e posteriormente separados entre machos e fêmeas em Eppendorfs com isopropanol. Na análise molecular, o DNA desses insetos será extraído e amplificados por PCR com primers específicos para Leishmania e para possíveis fonte de repasto sanguíneo (galinha, cão e humano). O produto da PCR será purificado e encaminhado para sequenciamento Sanger. Resultados preliminares: A partir dos dados coletados na literatura, foram criadas planilhas com as principais informações de diversos artigos científicos. Foi realizado o treinamento para o uso e montagem das armadilhas CDC e posteriormente foram testadas em locais suscetíveis, comprovando a sua eficácia ao capturar diversos insetos e mosquitos. Até o momento, foram encontrados 20 espécimes de flebótomos na região pesquisada, entre eles 11 machos e 9 fêmeas. Esses mosquitos foram acondicionados em isopropanol a -20°C para preservar o material genético. Conclusão: Até o momento, foi possível identificar que existe a presença de flebótomos na região pesquisada e que todos os processos realizados foram eficazes para a captura e armazenamento desses insetos.
Efeitos da Fisioterapia na Funcionalidade do Membro Superior e na Qualidade de Vida de Mulheres com Câncer de Mama pós Mastectomia
Authors: Mello Beatriz , Brentini Karime Sílvia , Coelho Vitória Helena Maciel
Published: July 2022

Introdução: O tratamento cirúrgico do câncer de mama pode influenciar na funcionalidade do membro superior ipsilateral à cirurgia, ocasionar linfedema, dor, fraqueza muscular e limitação das atividades de vida diária, interferindo na qualidade de vida dessas mulheres. A fisioterapia se torna fundamental na prevenção desses fenômenos e na sua reabilitação. Objetivo: Avaliar os efeitos da fisioterapia na amplitude de movimento (ADM), força muscular (FM), linfedema e qualidade de vida (QV) em mulheres pós mastectomia antes e após a intervenção fisioterapêutica. Metodologia: O presente estudo contará com a participação de 10 mulheres diagnosticadas com câncer de mama pós mastectomia, com idade entre 35 e 60 anos, provenientes da central de quimioterapia do HC-UFTM, que serão submetidas a um protocolo de 24 sessões de tratamento fisioterapêutico a ser realizado uma vez por semana composto por alongamentos, exercícios funcionais para membros superiores, exercícios respiratórios e para o condicionamento cardiovascular. Serão avaliadas a funcionalidade do membro superior homolateral, mobilidade do ombro, força da mão, circunferência de linfedema, e a qualidade de vida das participantes. Resultados esperados: Pressupõe-se que a fisioterapia promoverá melhora da funcionalidade e qualidade de vida das mulheres participantes do estudo com os dados obtidos. Conclusão: O estudo tem a finalidade de fornecer subsídios para que todos os profissionais de saúde envolvidos na equipe de tratamento de mulheres com câncer de mama atentem-se a necessidade de intervenções que possam proporcionar uma assistência integral às essas mulheres.
Perfil de expressão gênica da via de deacetilação de histonas mediada por Sirtuinas na estratificação prognóstica da Síndrome Mielodisplásica
Authors: Goes João Vitor Caetano , Carvalho Luiz Gustavo , De Oliveira Roberta Taiane Germano , Melo Mayara Magna de Lima , Viana Mateus de Aguiar , Sampaio Leticia Rodrigues , De Oliveira Vanessa Silva , Pinheiro Ronald Feitosa , Ribeiro Junior Howard Lopes
Published: July 2022

Introdução: A relação entre a senescência e o câncer é alvo de estudos, tanto em contexto carcinogênico quanto na supressão tumoral. Considerados importantes marcadores de envelhecimento, as sirtuinas podem auxiliar na medicina preventiva do câncer. Entretanto, estudos com esses marcadores em Síndrome Mielodisplásica ainda são escassos. Objetivo: Investigar o papel das sirtuinas (SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6 e SIRT7) na patogênese e na evolução prognóstica da Síndrome Mielodisplásica em um estudo do tipo caso-controle retro-prospectivo. Metodologia: Foram selecionados 106 pacientes diagnosticados para SMD e 11 indivíduos saudáveis pareados por sexo e idade cujo as amostras de aspirado de medula óssea serão coletadas e armazenadas em freezer -80°. Análises de citogenética por banda G foram realizadas para todos os pacientes e as expressões das sirtuinas serão realizadas por RT-qPCR. Análises in sílico de predição de expressão gênica das sirtuinas foram realizadas pelo GEPIA (Gene Expression Profilling Interactive Analysis). Os achados citogenéticos e moleculares serão correlacionados com dados clínico-epidemiológicos e laboratoriais coletados via banco RedCap.  Resultados Preliminares: Em análise de dados clínico-epidemiológicos, verificou-se que os pacientes são, predominantemente, do sexo feminino (55,26%) com idade média de 69 anos (70,30%). Os pacientes apresentaram, prioritariamente, cariótipo normal (57,89%) enquanto 25% apresentaram alterações citogenéticas, principalmente relacionadas à del(5q) e +7. Em análise de predição in sílico, foi identificado que, para LMA, SIRT3, SIRT4, SIRT5 e SIRT7 estavam downregulated, enquanto que a expressão de SIRT1 e SIRT2 estavam upregulated quando comparada aos tecidos normais (p<0.05). Conclusão: Este é o primeiro estudo que irá relacionar o papel das sirtuinas na patobiologia da SMD. Atualmente, estamos em fase final de recrutamento dos indivíduos de grupo controle e início das análises de expressão gênica. Assim, a partir da análise in sílico, espera-se que a expressão das sirtuinas possa representar possíveis novos marcadores de diagnóstico e prognóstico para SMD.
O papel da azacitidina, da carboplatina e do paclitaxel no potencial tratamento dos tumores de células germinativas resistentes a cisplatina
Authors: Oliveira Vanessa Monteiro , Rosa Marcela Nunes , Lengert André von Helvoort , Reis Rui Manuel Vieira , Lopes Luis Fernando , Pinto Mariana Tomazini
Published: July 2022

Introdução: Os tumores de células germinativas (TCGs) são neoplasias benignas ou malignas derivadas de células germinativas primordiais que ocorrem em sítios gonadais e extragonadais. O tratamento padrão é a ressecção cirúrgica e quimioterapia à base de cisplatina. Entretanto, um número significativo de pacientes recidiva por adquirir resistência a esse composto, por meio de mecanismos multifatoriais ainda incertos. Objetivo: analisar o efeito in vitro das drogas azacitidina, carboplatina e paclitaxel em TCGs resistentes à cisplatina. Metodologia: Células resistentes à cisplatina (NTERA-2R) foram tratadas com doses incrementais de cisplatina por aproximadamente 10 meses até o fenótipo de resistência. As células NTERA-2R foram caracterizadas quanto à formação de colônias e migração celular. Em seguida, as células parentais (NTERA-2P) e resistentes foram tratadas com azacitidina, carboplatina e paclitaxel e a viabilidade celular foi avaliada. Resultados: Após o tratamento com cisplatina, as células NTERA-2R tiveram um IC50 sete vezes maior do que as NTERA-2P. Em condições basais, houve aumento na formação de colônias e migração celular para NTERA-2R. Após 72 horas de tratamento com Carboplatina, valores de IC50= 29,02±1,58 μM (média ± desvio padrão) foram obtidos para NTERA-2R e 2,09±0,55 μM para NTERA-2P, sugerindo menor potência nas NTERA-2R devido a resistência cruzada com a cisplatina, pois compartilham o mesmo mecanismo de ação. O tratamento com Azacitidina em ambas as linhagens NTERA-2 mostrou-se eficaz, com IC50= 5,54±3,03 nM em NTERA-2P e 6,5±0,06 nM em NTERA-2R, provavelmente devido ao mecanismo de ação farmacológico diferenciado. Foi observado no tratamento com Paclitaxel (NTERA-2P: IC50= 20,24±4,99 nM e NTERA-2R: IC50= 20,58±2,48 nM). Tanto a NTERA-2P quanto a NTERA-2R responderam de forma semelhante após o tratamento com azacitidina e paclitaxel, sugerindo que ambos podem ser uma opção para cepas resistentes à cisplatina. Conclusão: Portanto, mais estudos são necessários para elucidar o efeito de diferentes quimioterapias na resistência à cisplatina em TCGs.
Análise de expressão e regulação do receptor gama ativado por proliferadores de peroxissoma (PPARγ) por meio do miR-17-5p em carcinoma hepatocelular
Authors: Possebon Vitória Scavacini , Peres Nathalia Perpétua , Marzochi Ludimila Leite , Kawasaki-Oyama Rosa Sayoko , Pavarino Érika Cristina , Castanhole-Nunes Márcia Maria Urbanin , Goloni-Bertollo Eny Maria
Published: July 2022

Introdução: O carcinoma hepatocelular (CHC) é o câncer primário de fígado mais frequente, abrangendo 90% dos cânceres hepáticos iniciados no fígado, e 70-80% de todos os cânceres de fígado. Os receptores ativados por proliferadores de peroxissoma (PPARs) são receptores nucleares ativados por ligantes, que atuam como fatores de transcrição, regulando a expressão de genes relacionados ao metabolismo de glicose e lipídios. O PPARγ compreende uma das três isoformas dos PPARs, atuando no processo de regulação da adipogênese, biossíntese e armazenamento de lipídios. As desregulações da expressão desses receptores sinalizam mecanismos que podem favorecer o desenvolvimento de doenças metabólicas hepáticas, e carcinoma hepatocelular. Os microRNAs (miRNAs) são pequenas moléculas de RNA reguladoras não codificantes, que atuam na regulação pós transcricional da expressão de genes-alvo. O miR-17‐5p desempenha um papel fundamental na patogênese de diversos tipos de câncer. Objetivo: Validar a relação entre o gene PPARγ e o miR-17-5p na regulação de sua expressão nas linhagens celulares HepG2 e Huh-7 de CHC. Metodologia: As células das linhagens HepG2 e Huh-7 foram cultivadas até que atingissem confluência de aproximadamente 80% para realização da técnica de transfecção reversa com o mirVanaTM miR-17-5p mimics. A transfecção foi realizada utilizando Lipofectamina RNAiMax. Após período de incubação, as células foram colhidas para extração do RNA, e foram realizadas as análises de expressão gênica e do microRNA por meio de PCR em tempo real (qPCR). Resultado: A expressão gênica do PPARγ apresentou diminuição nas células transfectadas com o miR-17-5p na linhagem de células Huh-7 (RQ=0,5953, p=0,0001), tal como na linhagem de células HepG2 (RQ=0,7677, p=0,0015) em relação ao controle negativo (RQ=1). Conclusão: A mimetização do miR-17-5p culminou na diminuição dos níveis de expressão do gene PPARγ nas células de linhagens HepG2 e Huh-7 de CHC. Logo, é possível que o miR-17-5p regule a expressão deste gene.
Current Status of Malnutrition in India and Government Initiatives to Improve Nutrition and Health
Authors: Sadaf Sharan
Published: July 2022

A person's intake of calories and nutrients might be deficient, excessive, or unbalanced in the case of malnutrition. The correct development and growth of a child, as well as their future socioeconomic status, depend greatly on the nutrition of the mother, the baby, and the child. In India, there are disturbingly high rates of malnutrition among children, pregnant and lactating mothers, and teenage females. Because nutrition is multidisciplinary and cross-sectoral, stakeholders must work closely together. Although various government initiatives are in placeand India has theoretically decreased malnutrition over the past ten years, there is still a need for effective application of research-based knowledge to address undernutrition, particularly because it hinders the socio-economic growth of the nation. These findings might be instructive for other developing nations aiming to lower child malnutrition in their regions. To reduce the incidence of malnutrition in India, it is necessary to build new programs, enhance the existing ones continuously, and incorporate a monitoring and assessment system.
Subconcussion, Concussion, and Cognitive Decline: The Impact of Sports Related Collisions
Authors: Dioso Emma , Cerillo John , Azab Mohammed , Foster Devon , Smith Isaac , Leary Owen , Goutnik Michael , LuckeWold Brandon
Published: July 2022

Subconcussion can cause long-term consequences for patients. Increasing understanding of what causes the injury and how it can be assessed is important. This paper focuses on the pathophysiology, epidemiology, and assessment tools. Specific emphasis is placed on early diagnosis to implement treatment. Current research is targeting improved pharmaceutic and biomechanic innovations. Enhanced understanding of subconcussion will improve outcomes for patients and allow clinicians to implement treatments earlier.
第四種支配的純粹類型：韋伯論民主之正當性基礎及其非正當性
Authors: 林子新 林子新
Published: July 2022

本文旨在闡明「民主」係韋伯眼中西方文明所特有的第四種支配類型。一般認為，韋伯根據作為統治者權威基礎的正當性思想的不同類型，僅僅區分出了三種支配的純粹類型，包括傳統型、法制型、以及卡理斯瑪型支配。問題是，韋伯曾在1917年的一場關於〈國家社會學的問題〉的演講中提到，西方不同於東方，具有逐漸形成的「第四種正當性思想(vierten Legitimitätsgedankens)」，又在關於西方城市特殊性的世界性歷史比較研究中，以及在1919年的〈政治作為一種志業〉演講和1920年版的《支配社會學》中反覆強調，西方特有的卡理斯瑪領袖的特殊之處，就在於開發出了一種全新且僅見於西方城市國家與立憲國家的正當性思想：「民主的正當性(demokratische Legitimität)」。若說韋伯確實是以正當性思想之類型差異做為其支配的純粹類型的劃分依據，加上韋伯又確曾將「民主的正當性」視為僅見於西方文明的第四種正當性思想，那麼我們便可以肯定地說：「民主」不只是韋伯眼中具有截然不同於傳統型、法制型、以及卡理斯瑪型支配之正當性基礎的第四種支配的純粹類型，更是唯一一種能夠突顯西方文明特殊性的支配的純粹類型。這樣的發現，不只有助於論者避免因為堅持韋伯只建構了三種支配的純粹類型，而得出韋伯的支配類型學並無助於增進吾人對於「民主」的理解的錯誤結論，更有助於論者在認識到「民主」係韋伯支配類型學中的第四種支配的純粹類型的同時，也能從韋伯關於支配類型的跨文明比較中進一步認識到「民主」所特有的正當性基礎及其非正當性。

 

This study investigated the concept of democracy in Max Weber’s theory of domination. The research results suggest that although Weber defined only three pure types of legitimate domination, he further classified charismatic domination into two types, conceptualizing “democracy” as the second type. The critical feature of this type of charismatic domination is that recognition from the ruled, once regarded as “a consequence of legitimacy,” has been primarily and oppositely treated as “the basis of legitimacy.” The findings assist in broadening Weber’s theory of domination through the integration of the fourth pure type of legitimate domination and in deepening our understanding of the legitimate basis of contemporary democracy.

 
“You Can Teach It”
Authors: Olmert Michael
Published: July 2022

No one hates Our Town. Its popularity is based largely on its supposedly simple display of the small-town values of acceptance and modesty. This article suggests that this notion—of a flawless and contented past—has always been useless and may now be fading away, at least in the minds and hearts of some of today’s undergraduates. In fact, Thornton Wilder’s play is brilliant because it uses simplicity to disguise wholesale misrepresentation, exaggeration, lies, sexism, xenophobia, cruelty, and rigid social control. In today’s world of widespread acceptance of lies for truth, it is bracing to notice Wilder’s (and Emily Webb’s) view of hypocrisy. Being alive is troubling and difficult enough, even when its everyday truth and beauty is right before our eyes. But when the parents, the neighbors, and the small-town government of Grover’s Corners manipulate truth to stay in power, everyone loses. The only solution, as Emily learns too late, is insistent Socratic questioning. That is, in every case, to ask: “What is this about, in the deepest sense?”
The Act of Interpretation
Authors: Hall Ann C.
Published: July 2022

This article discusses various ways to teach Thornton Wilder’s script and Alfred Hitchcock’s film version of Shadow of a Doubt (1943). While serving as a metaphor for academic research, Shadow of a Doubt is also rich enough to present students with the question of interpretation: How can one work create multiple, even conflicting, meanings? After introducing basic film techniques and literary terms, more complicated interpretive situations, such as Hitchcock’s problematic representation of women or the differences between script and film, may be considered. Students, like the film’s heroine, must investigate the evidence to find responses to these issues.
Laparoscopic radical cholecystectomy for carcinoma gallbladder: A case series
Authors: Gupta Ashutosh , Choraria Amit , Tiwar Shantanu , Dubey Hitesh , Kumar Agrawal Rajesh , Nandi Sourabh , Chaudhary Vivek
Published: July 2022

Introduction: Nowadays laparoscopic surgery is a very common form of treatment strategy for digestive diseases and these ‘keyhole’ surgeries provide many benefits to the patients. However, controversy exists when the laparoscopic surgery is done for early gallbladder cancer. The aim of our study was to report two such cases to see feasibility and safety of laparoscopic radical cholecystectomy with lymph node dissection.
Case Series: Two patients underwent laparoscopic radical cholecystectomy with lymph node dissection for gallbladder carcinoma. Both patients were preoperatively diagnosed. Mean operative time was 172 minutes, and average estimated blood loss was 225 ml. There was no intraoperative complication. The liver dissection was done by Harmonic in one case and by Waterjet in the other case. Average hospital stay after surgery was four days. Postoperative morbidity included minimal bile leak in one patient only and no bile leak in patient operated with Waterjet system. Postoperative histopathology revealed adenocarcinoma of gallbladder with no lymph node invasion T2N0M0 (Stage II) in both patients. The mean lymph node retrieval was 5.5. Both patients received adjuvant chemotherapy with gemcitabine and carboplatin.
Conclusion: We conclude that laparoscopic radical cholecystectomy with lymph node dissection is safe and beneficial for the patients with T1b/T2 gallbladder carcinoma and is useful in selected patients with a preoperative suspicion of early-stage gallbladder cancer by sparing them the necessity of a second-stage open procedure.
High level design to diagnosis glaucoma using CNN
Authors: Nandha Kumar R , Sudhakar Ilango S
Published: July 2022

To minimize long-term structural damage and irreversible visual loss, glaucoma must be diagnosed early. Glaucoma is diagnosed by assessing visual activity as well as monitoring structural damage to the optic nerve. Transparent laser ophthalmoscopy scanning, and laser polarimetry are examples of computer-based equipment that can aid in the analysis of visual acuity and structure. Most persons with glaucoma do not experience any early signs or pain. Glaucoma must be diagnosed and treated by an eye doctor on a regular basis. Traditional glaucoma detection procedures include an eye doctor analyzing photographs and looking for irregularities. Because the image contains noise and other elements that make appropriate analysis difficult, this method takes a long time and is not always precise. In addition, a machine that has been educated for analysis becomes more accurate than a human analyst. The proposed method will automate this procedure by employing deep learning techniques in image processing to diagnose glaucoma without the need for human intervention.
Assessment of growth-related hormones in patients with hereditary hemoglobinopathies
Authors: Kadim Ghfran A. , Ibraheem Shrouk A. Hassan Al. , Abbas Hamid Jaddoa
Published: July 2022

Background: Hemoglobinopathies are global public health problems affecting developed and non- developed countries with major consequences for human health as well as economic and social development. Patients with hemoglobinopathies often present with endocrine abnormalities due to iron overload, such as pituitary disease which responsible for growth hormone secretion. Therefore, the aim of this study was to assess the effect of iron over on growth in patients with hemoglobinopathies. Methods: A case control study, that included (140) patients with hemoglobinopathies and (50) healthy participants as a control. Growth hormone (GH), insulin like growth factor- 1 (IGF-1) and insulin like growth factor binding protein (IGFBP) were measured by standard mothed. Results: there were significant decrease level of GH, IGF-1and IGFBP; while there were increase level of ferritin, AST, ALT & LDH in hemoglobinopathies patients. Conclusions: There were decreases level of growth-related hormones and IGF-1 is the more sensitive test in assessing growth retardation due iron overload, which needs treatment at an appropriate age.
Evaluation the results of antiglide plating of vertical medial malleolus fractures
Authors: Abdelaal Elsayed Salah Elsayed , Elgoushy Ali Mohamed , Akl Mohamed Nasr
Published: July 2022

Background; Vertical shear fractures of the medial malleolus occur through supination–adduction loading of the talus onto the articular surface of the medial malleolus, Aim and objectives; to assess the radiological and functional outcomes of open reduction and internal fixation with antiglide plate of vertical shear medial malleolus fracture, Subjects and methods; This prospective case series study was carried out at the Orthopedics Departments of Al-Azhar University and Health Insurance Hospitals. The study included 22 patients with antiglide plating of vertical medial malleolus fracture. The duration of the study ranged from 6-12 months, Result; Number of patients with Antiglide plate for medial malleolus Management in the study population was 9 (40.91%). Number of patients with Antiglide plate for medial malleolus & Semitubular Plate of  lateral malleolus Management in the study population was 13 (59%), Conclusion; Surgical management of vertical shear of medial malleolus fracture gave excellent anatomical reduction and rigid fixation to restore articular congruity, help to facilitate early mobilization and hence to achieve optimal ankle function. The antiglide plate fixation is readily available and cost significantly less than a precountoured anatomicspecific type of fixation.
study of blood stream infesctions in intensive care units, government hospital, Ambikapur
Authors: Murthy Ramanesh , Gundala Obulesu , Murthy Madhumita , Mahaboob R. Salma
Published: July 2022

Any bacterial cells found in the blood should raise concern because it is sterile. Bacteremia is the term used to describe the presence of live, transitory bacteria in the blood. However, in the majority of bacteremic conditions, only a tiny number of bacterial cells enter, and no symptoms appear because the transients are quickly eliminated. immune blood cells eliminate. Aim: a study of blood stream infesctions in intensive care units, government hospital,ambikapur. MATERIALS AND METHODS :The study was carried out in the department of microbiology, central laboratory RSDKSGMC and Hospital, Ambikapur, CG. STUDY PERIOD: Oct 2021 to Dec 2021.Total 150 Number of patients. The study was approved by the ethical committee of RSDKS GMC, Ambikapur, Surguja, C.G. with reference number 2388A/GMC/2021/06-04-2021. CONCLUSION: To enhance the clinical outcome of BSIs in the ICU setting, several techniques should be put into practise. An immediate start to an investigation is still crucial.effective antibiotic therapy that should be personalized. Depending on the source of the illness in each individual patient,the likelihood of antibiotic resistance as well as the most frequently isolated bacteria.
Acute kidney injury profile of COVID-19 patients and associated risk factors a rural hospital-based retrospective study from Vadodara, Gujarat
Authors: Vaghani Nidhi , Pandya Apurvakumar , Priyadarshini Ankita , Patadia Hemantkumar
Published: July 2022

Background: Clinical outcome of patients hospitalized with COVID-19 and acute kidney injury (AKI) are not well understood. The clinical significance of abnormal electrolytes and renal outcome in COVID-19 patients have been poorly documented. We aim to exhibit the electrolyte abnormalities, renal outcome and associated risk factors in hospitalized COVID-19 patients in rural tertiary care hospital in Vadodara district, Western India. Method: A hospital record based retrospective study was conducted. Total 994 patients hospitalized with COVID-19 between 1st April 2021 to 30th June 2021 and those meeting inclusion criteria were included for the analysis. The laboratory data of interest included electrolytes reports like Na+, K+, CL-, creatinine and blood urea. Result: Of the total hospitalized COVID-19 patients, 324 patients were eligible. For the criteria for suspected AKI - 279 (86.11%) and no AKI - 45 (13.88%) patients were found. Suspected AKI patients were classified into four conditions: 1) HYPERNATREMIA (14.33%); HYPERKALEMIA (2.15%); BCR ratio >20 (65.59%); HIGH Cl- (17.92%). Out of total AKI patients, (36.91%) died whereas (13.3%) patients died in no AKI group. All patients were provided antibiotics, steroids and anti-viral therapies irrespective of AKI status, which we presume might have contributed in high mortality among suspected AKI.
La utilización de robótica en la inspección de espacios confinados
Authors: PINZÓN BARRIGA LUIS ENRIQUE
Published: July 2022

Las inspecciones en espacios confinados por lo general suelen tratarse de labores peligrosas, por motivos como la altura, poco espacio de maniobra, derrumbes, ambiente toxico, temperaturas elevadas o bajas, entre otros; además de ser un riesgo a la integridad física, son labores que demandan tiempo, logística y equipos de seguridad, por esas razones ya se empiezan a utilizar equipos robóticos que tienen como ventaja principal la eliminación del riesgo físico en las personas que realizan la inspección y como ventajas secundarias el ahorro económico, ahorro de tiempo y simplificación generalizada de la labor. Los robots móviles autónomos (AMR) asistidos a distancia por seres humanos son los idóneos para la realización de las inspecciones de alto riesgo, los cuales pueden ser de morfología terrestre, acuática, submarina o área, según sean las necesidades. Cualquier espacio confinado a inspeccionar donde existan variables de riesgo a la seguridad humana, valida la implementación de equipos robóticos, sin embargo, ya existen sectores acostumbrados a este tipo de inspecciones, los cuales son: petróleo y gas, generación de energía, industria química, minería y seguridad pública.
Características y ventajas existentes en la conexión inalámbrica y fibra óptica. Una revisión bibliográfica
Authors:   Universidad Metropolitana de Educación, Ciencia y Tecnología, Panamá., GODOY TRUJILLO PAMELA ESTEFANÍA
Published: July 2022

El internet definitivamente revoluciono el mundo y la forma de comunicación, no es un secreto que este nuevo método de comunicación ha llegado a ocupar prácticamente todo el escenario mundial a tal punto que hoy en día casi ninguna empresa se maneja de otra manera si no tiene algún equipo conectado vía internet hacia el mundo, recientemente con la llegada de la pandemia por el Covid 19, el planeta entero fue testigo de la gran importancia que esta tecnología reviste para la economía mundial, a tal punto que su uso llego a determinar entre que una empresa sobreviviera al fuerte confinamiento mundial o no. Esto se debe a que el internet es una herramienta que permite la conexión de diferentes tipos de dispositivos tanto corporativos como personales con cualquier persona en el mundo en tiempo real. En este sentido, existen diferentes tipos de conexiones a la red, entre las que se destacan la conexión inalámbrica y la conexión por fibra óptica. Esta investigación realiza una revisión actualizada de las diferencias entre este tipo de conexiones así como sus ventajas y desventajas, mediante la metodología de revisión bibliográfica. Existen pros y contras para ambos métodos de conexión, pero sin duda alguna la fibra óptica proporciona más estabilidad en el servicio y mucha más versatilidad en sus materiales.