bluuebunny/crossref_metadata_2025 huggingface dataset:
PPELATIHAN PENGELOLAAN LIMBAH PLASTIK MENJADI KERAJINAN TANGAN GUNA MENINGKATKAN KREATIFITAS ANAK-ANAK
Authors: Hikmawati Agci , Haritsyah Haritsyah , Prabowo Muhammad Yunan , Hafiz Al-Badrul , Sapitri Desi , Martari Sindy , Nofiri Murni , Widayanti Widayanti , Dari Rhesdea Wulan
Published: May 2022

The aim of the program is to provide training in the use of plastic waste and to improve the effectiveness of children in ketapang in managing plastic waste into attractive, useful and valuable crafts. This training was conducted in Tanjung Ketapang village on 18 to 19 Febuarai 2020. In this training there were 10 participants and 11 students. This method of training used the technique (1) of socialization for material delivery to the participants, (2) The implementation of plastic waste management practices into flower pot-shaped handicrafts, (3) reflections made to evaluate the activities. The result of this community devotion is handicraft in the form of flower pots from used plastic material. This training enhances the creativity of children from works that have an artistic value that has a variety of motives.Â
PENINGKATAN KESADARAN LINGKUNGAN DENGAN PELATIHAN PENGOLAHAN SAMPAH DI DESA SUMBERMULYO KECAMATAN BAMBANGLIPURO
Authors: Mulasari Surahma Asti , Bayu Mohammad , Inaz Aulya
Published: May 2022

Bambanglipuro sub-district is a sub-district in the lowlands. The Capital District is 22 meters above sea level. Distance of the Capital District to the Government Center (Capital) of Bantul Regency is 10 Km. Bambanglipuro sub-district has a climate like a low-lying area in the tropics with hot weather as its trademark. The highest temperature recorded in Bambanglipuro sub-district is 31ÂºC with the lowest temperature of 23ÂºC. The area stretch in Bambanglipuro sub-district is 99.5% in the form of flat to choppy areas and 0.5% in the form of choppy to hilly areas. The purpose of this service was to create a community of Sumbermulyo Village, Bambanglipuro sub-district who is independent, especially in terms of waste management and to improve the economy of Sumbermulyo Village, Bambanglipuro sub-district through the results of waste management in the environment. The method used in this service is through counseling and training on waste management located in Sumbermulyo Village, Bambanglipuro sub-district in February 2020 with a predetermined date. Community service has been carried out well and smoothly. Sumbermulyo Village Community Bambanglipuro sub-district shows a positive response and plays an active role in all the activities carried out. The community wants that there is further guidance, especially in the field of waste management so that community empowerment can run optimally Â
SPP Program: An effort to prevent Covid-19 in Tenayan Raya District, Pekanbaru Indonesia
Authors: Darmansyah Ramlan , Idris Ndaru , Desfri Feri , Astuti May Sri , Hedayati Nissa , Zafitra Ferby Hidayat , Annisa Mutiatul , Aprilia Nadia , Simatupang Roma Florentina , Wulandari Fenita
Published: May 2022

Tenaya Raya district Pekanbaru Indonesia was the second higher rank area of covid-19 spread in Pekanbaru city. We did a Community empowerment program: SPP (Socialization, Prevention, and Data Collection) in Tenayan Raya District. The program's implementation was done for 14 working days, started from June 15 to 30, 2020. The socialization activity aimed to understand the importance of Covid-19 prevention through media such as; brochures and banners in Tenan Raya district. Moreover, the socialization activity also was done by counseling for markets and daily merchants. Then, prevention activities were like disinfectant spraying, masker distribution, hand washing facilities for comfortable and safe activities. In addition, the data collection activity about community medical history was used for policy-making related to Covid-19 prevention. The method that was used in this research was counseling and speech or gave information about Covid-19 to the community. The result was the socialization program, and Covid-19 prevention was done well, which can be perceived as improving the community understanding about Covid-19. It can be seen by community awareness in using masker, washing hand in a public place, for example; market place and disinfectant spraying in worship place twice or three times a week.
Trends in Acupuncture Training Research: Focus on Practical Phantom Models
Authors: Jang Jung Eun , Lee Yeon Sun , Jang Woo Seok , Sung Won Suk , Kim Eun-Jung , Lee Seung Deok , Kim Kyung Ho , Jung Chan Yung
Published: May 2022

The purpose of this review was to identify research trends in acupuncture training systems and models and to analyze acupuncture training using phantom models. Articles on acupuncture training were retrieved from domestic and foreign electronic databases (PubMed, CNKI, CiNii, NDSL, KISS, RISS and KMBase). The search included studies conducted from January 1, 2010 to October 1, 2021. Acupuncture training was analyzed by categorization into acupoint location training and needling training. Acupuncture training was most frequently studied in China, acupoint location training was the most studied in 2012, and needling training was the most studied in 2013 and 2020. Among them, a silicone model with a sensor was used for training in acupoint location, and silicone and agarose gel were frequently used for needling training. Classifications of the phantom models for needling training by topic included phantom development, phantom-based education and evaluation system, phantom-based quantitative measurement, comparison of kinematic characteristics of hand motion between experts and beginners, and phantom models for acupoint location and needling training. Further research on the development of acupuncture practice training systems to improve practical skills is needed.
64-channel label-free fluorescence detection and single-particle counting device
Authors: Chen Siying , Du Xianda , Chen He , Guo Pan , Zhang Yinchao , Wu Huiyun
Published: May 2022

A 64-channel detection system for laser-induced fluorescence (LIF) detection at the cell level is established and applied to single event counting. Generally, fluorescence detection at the cellular level requires a dyeing label to enhance the scattered light intensity for the photodetector. However, the dyeing labels, such as fluorophores, probes, and dyes, complicate sample preparation and increase cytotoxicity in the process. Therefore, label-free detection becomes essential for in vivo research. The presented 64-channel detection system is designed for label-free detection with the ability to record feeble emissions. Two linear photodetector devices are included in the system, extending the wavelength detection range to 366–680 nm with an improved spectral resolution at an average of 4.9 nm. The performance of the system was validated by detecting unlabeled human hepatocytes (L-02) and other cell-level biologic samples. In addition, the 64-channel detection system was also used for particle counting with a quartz microfluidic chip. The counting method is based on fluorescence spectra differs from those of other devices (i.e., flow cytometry and cell-sorting equipment), which use isolated irradiance intensities.
Towards fast sensing along ultralong BOTDA: flatness enhancement by utilizing injection-locked dual-bandwidth probe wave
Authors: Yang Yulian , Liu Liming , Deng Qingxue , Jia Xinhong , Wu Han , Liang Wenyan , Jiang Li , Song Weijie , Ma Huiliang , Lin Jiabing , Xu Shirong
Published: May 2022

Brillouin optical time-domain analysis (BOTDA) using distributed Brillouin amplification (DBA) only requires a milliwatt-level pump to achieve a sensing range beyond 100 km, which provides a powerful tool for temperature/strain sensing. However, similar to the majority of other long-range BOTDAs, the state-of-the-art reports require > 1000 times average, severely restricting the sensing speed. The blind area over tens of kilometers caused by the nonuniform Brillouin response and parasitic amplitude modulation (AM) are crucial factors affecting the signal-to-noise ratio (SNR). Here, a comprehensive performance optimization and substantial enhancement for BOTDA sensors was presented by the direct demodulation of an injection-locked dual-bandwidth probe wave. Injection locking (IL) can completely eliminate the impact of AM noise; dual-bandwidth probe enables self-adaptive pulse loss compensation, thereby intensifying the SNR flatness along the ultralong fiber, and direct probe demodulation can overcome nonlocal effects and allows ∼19.7 dB enhancement of probe input power. Therefore, using only 100 times average, ∼148.3 km sensing, and ∼5 m spatial resolution were achieved with < ∼0.8 MHz standard deviation of Brillouin frequency shift (BFS) over a broad range (∼131.7 km). The reduction in averages was more than 10 times that of the reported majority of long-range BOTDAs. Such performances were achieved without using time-consuming or post-processing techniques, such as optical pulse coding and image denoising. Because this approach is compatible with optical chirp chain technique without frequency sweeping, fast acquisition (0.3 s) was also realized, which has the potential for fast sensing at 3.3 Hz along a ∼150 km fiber.
Single-mode narrow-linewidth fiber ring laser with SBS-assisted parity-time symmetry for mode selection
Authors: Deng Zhenpeng , Li Lingzhi , Zhang Jiejun , Yao Jianping
Published: May 2022

A single-longitudinal-mode narrow-linewidth fiber ring laser with stimulated Brillouin scattering (SBS) assisted parity-time (PT) symmetry for mode selection in a single fiber loop is proposed and experimentally demonstrated. When an optical pump is launched into the fiber loop along one direction, an SBS gain for the Stokes light along the opposite direction is produced. For two light waves at the Stokes frequency propagating along the two opposite directions, one will have a net gain and the other will have a net loss. By incorporating a fiber Bragg grating (FBG) with partial reflection in the loop, mutual coupling between the two counterpropagating Stokes light waves is achieved. The SBS gain can be controlled by tuning the angle between the polarization directions of the pump and the Stokes light waves through a polarization controller (PC). Once the gain and loss coefficients between the two counterpropagating light waves are controlled to be identical in magnitude, and that the gain coefficient is greater than the coupling coefficient caused by the FBG, PT symmetry breaking is achieved, making the mainmode to sidemode ratio highly enhanced, single mode lasing is thus achieved. The approach is evaluated experimentally. For a fiber ring laser with a cavity length of 8.02 km, single-mode lasing with a narrow 3-dB linewidth of 368 Hz and a sidemode suppression ratio of around 33 dB is demonstrated. The wavelength tunable range from 1550.02 to 1550.18 nm is also demonstrated.
Development of a low-cost silica-titania optical platform for integrated photonics applications
Authors: Butt M. A. , Tyszkiewicz C. , Karasiński P. , Zięba Magdalena , Hlushchenko D. , Baraniecki T. , Kaźmierczak A. , Piramidowicz R. , Guzik M. , Bachmatiuk A.
Published: May 2022

This paper investigates a highly attractive platform for an optical waveguide system based on silica-titania material. The paper is organized into two parts. In the first part, an experimental study on the development of an optical waveguide system is conducted via the sol-gel dip-coating method, and the optical characterization of the waveguide system is performed at a visible wavelength. This system is capable of operating from visible to near-IR wavelength ranges. The experimental results prove the dominance of this waveguide platform due to its low-cost, low loss, and easy to develop integrated optics systems. The numerical analysis of a one-dimensional Photonic crystal waveguide optical filter based on the silica-titania platform is considered in the second part of the paper by utilizing the 2D-finite element method (2D-FEM). A Fabry-Perot structure is also analyzed for refractive index sensing applications. We believe that the results presented in this work will be valuable in the realization of low-cost photonic integrated circuits based on the silica-titania platform.
Mitigation of amplified spontaneous emission noise for an all-fiber coaxial aerosol lidar with different single-photon detectors
Authors: Qiang Wei , Yang Bin , Shang Xiang , Wang Chong , Xue Xianghui , Chen Tingdi
Published: May 2022

For a coaxial single-photon lidar system, amplified spontaneous emission (ASE) noise from the fiber amplifier is inevitable. The ASE backscattering from specular reflection annihilates the far-field weak signal, resulting in low signal-to-noise ratio, short measurement distance, and even misidentification. We propose a method for calibrating and mitigating ASE noise in all-fiber coaxial aerosol lidar and demonstrate the method for a lidar system with different single-photon detectors (SPDs). The accuracy of the coaxial aerosol lidar is comparable to that of the biaxial one. We conducted an experiment using three different detectors, namely, InGaAs/InP SPD, up-conversion SPD, and superconducting nanowire SPD in the same coaxial lidar system. Compared with the biaxial system, the three different detectors we used have achieved more than 90% ASE noise suppression, the measured visibility percent errors of InGaAs/InP SPD data, up-conversion SPD data, and superconducting nanowire SPD data all within 20%, and the percent error within 10% are 99.47%, 100%, and 95.12%, respectively. Moreover, time-sharing optical switching allowed to obtain background noise with high accuracy.
Unique surface polaritons and their transitions in metamaterials
Authors: Peng Hongyan , Wang Xuan-Zhang
Published: May 2022

We investigated surface polaritons in a metamaterial composed of polar-crystal layers and antiferromagnetic layers. In a specific geometry, two surface polaritons were predicted, which are a unique ghost surface polariton (GSP) and surface hybrid-polarization polariton (SHP). The two surface polaritons occupy different segments of one smooth dispersion curve and are magnetically tunable. An external magnetic field along the antiferromagnetic easy axis can bring about the switch or transition between the two surface polaritons and meanwhile performs the necessary condition for the existence of two surface polaritons. In the metamaterial, either surface polariton consists of two branch waves. The branch waves of the GSP are coherent and have the same amplitude and different phases, but those of the SHP are not coherent and have different amplitudes and phases. The main characteristic of the GSP is that its fields oscillate and attenuate with the distance away from the metamaterial surface and exhibit interferent fringes on the plane normal to the surface.
Beamshaping for infrared hyperspectral imaging: a sequential optimization for infrared source coupling
Authors: Azizian Kalkhoran Mohammad , Douglas Winter A. , Cinque Gianfelice
Published: May 2022

Focal plane array (FPA) detectors have escalated Fourier transform infrared (FTIR) microspectroscopy to a potent hyperspectral imaging method. Yet, despite the instrumental multiplex/multichannel advantages, the fidelity of the hyperspectral images relies on the throughput as the total flux of the source is divided among each FPA pixel. Additionally, maintaining the spectral resolution requires a certain level of collimation of the beam which adversely affect the flux of high étendue source. To this end, we propose an implementation of two deformable mirror (DM) sensorless adaptive optics system for infrared (IR) source coupling. The deflection shape of each DM membrane is optimized individually to deal with the beam intensity and the rays’ direction in a separate manner, while preserving the spectral quality across the entire mid-IR range. This paper contemplates the choice of metrics in sequential optimization in conjunction with two variations of stochastic parallel gradient descent optimization algorithm. We discuss this approach with respect to a state-of-the-art FTIR microscope.
Community-wide prevalence and intensity of soil-transmitted helminthiasis and Schistosoma mansoni in two districts of Sierra Leone
Authors: Tupps Cara , Kargbo-Labour Ibrahim , Paye Jusufu , Dhakal Sanjaya , Hodges Mary H. , Jones Alexander H. , Davlin Stacy , Sonnie Mustapha , Manah Sallay , Imtiaz Rubina , Zhang Yaobi
Published: May 2022

In Sierra Leone, nationally powered school-based surveys have documented significant progress in the control of soil-transmitted helminthiasis (STH) and schistosomiasis. In order to assess the district-level prevalence and intensity of infection among key at-risk groups outside of school age children (SAC), we conducted a multi-stage, cluster-sample household survey in Bo and Kenema districts in May 2018. From both districts, we examined 1,282 pre-school age children (PSAC), 730 school age children (SAC), and 517 adults over 14 years (including 387 women of reproductive age, or WRA) for STH and Schistosoma mansoni infection using Kato Katz technique. In Bo, STH prevalence was 8.0% (95% Upper Confidence Limit 10.2%) in PSAC, 6.4% (95% Upper Confidence Limit 9.0%) in SAC, 14.1% (95% Upper Confidence Limit 17.4%) in all adults and 11.9% (95% Upper Confidence Limit 17.4%) in WRA. In Kenema, STH prevalence was 18.1% (95% Upper Confidence Limit 20.5%) in PSAC, 17.3% (95% Upper Confidence Limit 20.7%) in SAC, and 16.9% (95% Upper Confidence Limit 20.5%) in all adults and 16.9% (95% Upper Confidence Limit 22.6%) in WRA. Hookworm species were the most prevalent of STH in both districts overall. The overall prevalence of S. mansoni was <10% in Bo and <20% in Kenema, and was similar across age groups. No moderate or heavy intensity STH infections or heavy intensity S. mansoni infections, as per World Health Organization (WHO) classification, were detected in either district. Sanitation variables, such as toilet access and quality, were independently associated with STH and S. mansoni infection. In Kenema, STH prevalence in SAC was within the WHO-defined range for annual treatment, whereas a previous nationally-powered survey estimated it to lie within the range of treatment once per two years. By utilizing community-based sampling, we were able to assess prevalence among WRA and make recommendations based on current guidance from WHO. To continue toward elimination of STH and S. mansoni as a public health problem, resources should be mobilized to increase access to and uptake of improved sanitation at community and household levels.
Based on network pharmacology and molecular docking to predict the mechanism of Huangqi in the treatment of castration-resistant prostate cancer
Authors: Lin Zesen , Zhang Zechao , Ye Xuejin , Zhu Min , Li Zhihong , Chen Yu , Huang Shuping
Published: May 2022

Background

As a kind of traditional Chinese medicine, HQ is widely mentioned in the treatment of cancerous diseases in China, which has been proven to have a therapeutic effect on cancerous diseases, such as prostate cancer. To predict the specific mechanism of HQ in the treatment of CRPC, we will conduct preliminary verification and discussion based on a comprehensive consideration of network pharmacology and molecular docking.

Methods

TCMSP was used to obtain the compounds and reach the effective targets of HQ. The targets of CRPC were reached based on GeneCards database and CTD database. GO and KEGG were utilized for the analysis of overlapping targets. The software of Openbabel was used to convert the formats of ligands and reporters. In addition, molecular docking studies were performed by using the software of Autodock Vina.

Result

It can be seen from the database results that there were 87 active compounds (20 key active compounds) in HQ, and 33 targets were screened out for CRPC treatment. GO and KEGG pathway enrichment analyses identified 81 significant GO terms and 24 significant KEGG pathways. There is a difference in terms of the expression of core protein between cancer patients and healthy people. The expression of core protein in patients also has an impact on the life cycle. The results of molecular docking showed that the docking activity of drug molecules and core proteins was better.

Conclusions

It is concluded from the results of this network pharmacology and molecular docking that HQ makes a multi-target and multi-biological process, and results in the multi-channel synergistic effect on the treatment of CRPC by regulating cell apoptosis, proliferation and metastasis, which still needs further verification by experimental research.
Risk assessment model for international construction projects considering risk interdependence using the DEMATEL method
Authors: Zhu Fengfeng , Hu Hao , Xu Feng
Published: May 2022

Given the complexity of international construction projects (ICP), risk management difficulties commonly cause cost overruns. This paper analyzes the problems of risk interdependence and subjective ratings in the application of the traditional risk assessment model in ICP. To solve the above problems, this paper proposes a risk assessment model for ICP that considers risk interdependence and obtains references from similar projects. The model applies the Decision-Making Trial and Evaluation Laboratory (DEMATEL) to determine the risk interdependence and its contribution to the overall project risk. Moreover, this model recalls the risks, probabilities, impacts, and risk events records of similar historical projects as the necessary inputs, thereby addressing the issue of subjectivity. An integrated framework is provided to identify, analyze, and prioritize ICP risks to incorporate risk interdependence into the risk management process. Finally, this paper demonstrates and validates the proposed model through a real project. The proposed model is useful for international construction companies to support project selection and bidding decisions in the early stage of ICP.
Ecosystem guidance for the incorporation of renewable utilities in a multi-use campus network
Authors: Warrington Shelby , Layton Astrid
Published: May 2022

Configuring the network connections in industrial, power, and water networks to mimic the structural patterns of ecological food webs has been shown to improve the resilience of human networks. This work investigates the ability of food web inspiration to specifically guide the incorporation of renewable energy and water sources for resilience. Feasibility is tested using the water and electricity networks of the Texas A&M University main campus, demonstrating the potential of university campus case studies as analogies for other multi-use networks, such as cities or industrial-commercial regions, due to the variety of functions met within the system boundaries. Ecological robustness, the unique and characteristic behavior of ecosystems to slightly favor redundancy over efficiency, is used to correlate the incorporation and supply-levels of solar power and rainwater collection in a realistic campus model with the overall resilience of the electricity and domestic water networks. Non-obviously, the results suggest that the ecologically-similar resilience is achieved when less than 100% of utilities come from renewable sources, indicating an important potential tradeoff between efforts to shift to 100% renewable sources and network resilience concerns.
Impact and benefit-cost ratio of a program for the management of latent tuberculosis infection among refugees in a region of Canada
Authors: Pépin Jacques , Desjardins France , Carignan Alex , Lambert Michel , Vaillancourt Isabelle , Labrie Christiane , Mercier Dominique , Bourque Rachel , LeBlanc Louiselle
Published: May 2022

Introduction

The identification and treatment of latent tuberculosis infection (LTBI) among immigrants from high-incidence regions who move to low-incidence countries is generally considered an ineffective strategy because only ≈14% of them comply with the multiple steps of the ‘cascade of care’ and complete treatment. In the Estrie region of Canada, a refugee clinic was opened in 2009. One of its goals is LTBI management.

Methods

Key components of this intervention included: close collaboration with community organizations, integration within a comprehensive package of medical care for the whole family, timely delivery following arrival, shorter treatment through preferential use of rifampin, and risk-based selection of patients to be treated. Between 2009–2020, 5131 refugees were evaluated. To determine the efficacy and benefit-cost ratio of this intervention, records of refugees seen in 2010–14 (n = 1906) and 2018–19 (n = 1638) were reviewed. Cases of tuberculosis (TB) among our foreign-born population occurring before (1997–2008) and after (2009–2020) setting up the clinic were identified. All costs associated with TB or LTBI were measured.

Results

Out of 441 patients offered LTBI treatment, 374 (85%) were compliant. Adding other losses, overall compliance was 69%. To prevent one case of TB, 95.1 individuals had to be screened and 11.9 treated, at a cost of $16,056. After discounting, each case of TB averted represented $32,631, for a benefit-cost ratio of 2.03. Among nationals of the 20 countries where refugees came from, incidence of TB decreased from 68.2 (1997–2008) to 26.3 per 100,000 person-years (2009–2020). Incidence among foreign-born persons from all other countries not targeted by the intervention did not change.

Conclusions

Among refugees settling in our region, 69% completed the LTBI cascade of care, leading to a 61% reduction in TB incidence. This intervention was cost-beneficial. Current defeatism towards LTBI management among immigrants and refugees is misguided. Compliance can be enhanced through simple measures.
Oncologic outcomes of Bacillus Calmette-Guérin therapy in elderly patients with non-muscle-invasive bladder cancer: A meta-analysis
Authors: Aghamir Seyed Mohammad Kazem , Khatami Fatemeh , Farrokhpour Hossein , Oliveira Reis Leonardo , Ahmadi Pishkuhi Mahin , Mohammadi Abdolreza
Published: May 2022

Introduction

There is a challenge on the medical efficacy of intravesical Bacillus Calmette-Guérin (BCG) therapy and the power of the immune system boosting, which can be influenced by the age of the non-muscle-invasive bladder cancer (NMIBC) patients. This meta-analysis evaluates the efficacy of BCG therapy among aged (>70) and younger patients with non-muscle-invasive bladder cancer (NMIBC).

Methods

The central database of PubMed, Scopus, and Web of Science were queried until August 4, 2021, by using "BCG," "Bladder Cancer," "AGE," and "efficacy" keywords. After excluding duplicated results, titles and abstracts were evaluated by two independent reviewers. The exclusion criteria included non-English studies, conference abstracts, reviews, editorials, letters, and comments. Three main outcomes, disease-free survival (DFS), progression-free survival (PFS), and cancer-specific survival (CSS), were considered. The statistical analysis was performed using STATA (version 14; Stata Corp, College Station, Texas, USA).

Results

From 1115 found documents, the 24 research articles were recruited in the systematic review, and 10 were the candidate for meta-analysis. The overall estimate of H.R. revealed that BCG therapy in those over age 70 is significantly associated with an improved risk of progression and cancer-specific death in studied patients. However, this association was not statistically significant for DFS (1.04 (95% CI: 0.85,1.26)).

Conclusion

The BCG maintenance therapy improved CSS and PFS oncological outcomes in elderly patients with NMIBC. BCG therapy did not significantly change the DSF.
Predictors of Hepatitis B screening and vaccination status of young psychoactive substance users in informal settlements in Kampala, Uganda
Authors: Ssekamatte Tonny , Isunju John Bosco , Mutyoba Joan Nankya , Tetui Moses , Mugambe Richard K. , Nalugya Aisha , Kansiime Winnifred K. , Kitchen Chenai , Brenda Wagaba , Oputan Patience , Bukenya Justine Nnakate , Buregyeya Esther , Kibira Simon P. S.
Published: May 2022

Background

Young psychoactive substance users exhibit high-risk behaviours such as unprotected sexual intercourse, and sharing needles and syringes, which increases their risk of Hepatitis B infection. However, there is limited evidence of screening, and vaccination status of this subgroup. The aim of this study was to establish the predictors of screening and completion of the hepatitis B vaccination schedule.

Methods

A cross-sectional study using respondent driven sampling was used to enrol respondents from twelve out of fifty-seven informal settlements in Kampala city. Data were collected using an electronic structured questionnaire uploaded on the KoboCollect mobile application, and analysed using Stata version 14. A “modified” Poisson regression analysis was done to determine the predictors of screening while logistic regression was used to determine the predictors of completion of the Hepatitis B vaccination schedule.

Results

About 13.3% (102/768) and 2.7% (21/768) of the respondents had ever screened for Hepatitis B, and completed the Hepatitis B vaccination schedule respectively. Being female (aPR 1.61, 95% CI: 1.11–2.33), earning a monthly income >USD 136 (aPR 1.78, 95% CI: 1.11–2.86); completion of the Hepatitis B vaccination schedule (aPR 1.85, 95% CI: 1.26–2.70); lack of awareness about the recommended Hepatitis B vaccine dose (aPR 0.43, 95% CI: 0.27–0.68); and the belief that the Hepatitis B vaccine is effective in preventing Hepatitis B infection (aPRR 3.67, 95% CI: 2.34–5.73) were associated with “ever screening” for Hepatitis B. Knowledge of the recommended Hepatitis B vaccine dose (aOR 0.06, 95% CI: 0.01–0.35); “ever screening” for hepatitis B (aOR 9.68, 95% CI: 2.17–43.16) and the belief that the hepatitis B vaccine is effective in preventing Hepatitis B infection (aOR 11.8, 95% CI: 1.13–110.14) were associated with completion of the hepatitis B vaccination schedule.

Conclusions

Our findings indicate a low prevalence of Hepatitis B screening and completion of the Hepatitis B vaccination schedule among young psychoactive substance users in informal settings. It is evident that lack of awareness about Hepatitis B is associated with the low screening and vaccination rates. We recommend creation of awareness of Hepatitis B among young people in urban informal settlements.
The pest control and pollinator protection dilemma: The case of thiamethoxam prophylactic applications in squash crops
Authors: Obregon Diana , Pederson Grace , Taylor Alan , Poveda Katja
Published: May 2022

A major challenge in sustainable agriculture is finding solutions to manage crop-damaging pests such as herbivores while protecting beneficial organisms such as pollinators. Squash is a highly pollinator-dependent crop that is also attractive to herbivores like the striped cucumber beetle. While synthetic insecticides can provide control of insect pests, they can also affect non-target organisms such as pollinators. Thus, growers need to balance pest management with pollinator protection to ensure optimal yield. Thiamethoxam is a commonly used systemic insecticide that translocates throughout plants, leaving residues in nectar and pollen. The aim of this study was to evaluate whether there are uses of this insecticide that provides efficient pest control while minimizing pesticide pollinator exposure. Specifically, we tested how different prophylactic application methods (seed treatments, in-furrow applications, and early foliar sprays) of commercially available thiamethoxam products impact pest control, bee visitation, yield, and pesticide residues in flowers of squash crops. We found that among the different methods of thiamethoxam application, in-furrow application best prevented defoliation and resulted in the highest fruit weight and number. However, it also produced the most frequent and highest concentrations of thiamethoxam in nectar and pollen, reaching lethal levels for squash bees. Our study provides evidence that under current application methods, thiamethoxam does not provide a sustainable solution for squash growers and further research is required on more efficient pesticide delivery methods, as well as non-pesticide pest control measurements.
Disposal practices of unused and expired pharmaceuticals among the general public in Quetta city, Pakistan
Authors: Shoaib Muhammad , Raziq Abdul , Iqbal Qaiser , Saleem Fahad , Haider Sajjad , Ishaq Rabia , Iqbal Zaffar , Bashaar Mohammad
Published: May 2022

Objective

Although community practices towards disposal of expired and unused medications vary globally, the phenomenon is neglected specifically in developing countries. We, therefore, aimed to assess the disposal practices of unused and expired pharmaceuticals among the general public in Quetta city, Pakistan.

Methods

A questionnaire-based, cross-sectional survey was conducted among 830 respondents in Quetta city, Pakistan. A pre-validated, structured questionnaire was used for data collection. Data were coded and analyzed by Statistical Package for Social Science (SPSS) version 26. Both descriptive and inferential statistics were sued and p<0.05 was taken as significant.

Results

Almost 87% of the respondents had unused medicines at their homes and reusing the medications was the purpose of medicine storage (50%). Medicines were mostly kept in refrigerators (36.0%) followed by bedrooms (28.8%). Fifty percent of the respondents never checked the expiry date before using the medications. The procedure to dispose of nearly expired or expired medicines was unknown to 88% of the respondents and for those reasons, medicines were disposed either in household trash or flushed in the toilet or sink. Interestingly, medicines were kept at home even after being expired by 27% of the respondents. Income was associated with reason of storing medicines (p = 0.004; φc = 0.402) while educational status had significant associations with storage of medications (p = 0.002; φc = 0.399), reading about storage instructions (p = 0.008; φc = 0.452) and checking expiry date before purchasing and using the medicines (p = 0.007; φc = 0.114 and p = 0.001; φc = 0.100) respectively.

Conclusion

Improper storage and disposal of unused and expired medications is a common practice among study respondents and raised serious concerns. Findings of the current study call upon immediate development and implementation of the strategies to promote awareness and strengthen the pharmaceutical waste management program at the societal level.
Prevalence and predictors of non-adherence to short-term antibiotics: A population-based survey
Authors: Almomani Basima A. , Hijazi Bushra M. , Awwad Oriana , Khasawneh Rawand A.
Published: May 2022

Non-adherence to antibiotics is a well-known, core player to antibiotic resistance. The current adherence behavior toward short-term antibiotic regimens has never been investigated before in Jordan. This study assessed the prevalence and predictors of non-adherence to short-term antibiotics among Jordanians and investigated participants’ views about different reasons related to antibiotics non-adherence. A cross-sectional face-to-face survey-based interview was conducted in three hospital pharmacies in Jordan. Adults and mother of children (≤12 years old) who completed their short course treatment (<30 day) of oral antibiotic within the last month were recruited. A total of 2000 participants (adults: 1000 and mothers of children: 1000) were included in the study with a response rate of 91.60%. The prevalence of non-adherence was estimated to be 32.10%. Non-adherent respondents scored a lower Medication Adherence Report Scale [16.76±5.02 vs. 23.04 ±3.24] than adherent respondents (p<0.001). Adults without comorbidity and children with higher number of doses per regimen were significantly less adherent to antibiotic [(OR = 0.615, 95%CI = 0.444–0.853, p = 0.004) and (OR = 0.965, 95%CI = 0.950–0.981, p<0.001)], respectively. Patients-related factors were the most common antibiotic non-adherence reason reported by the participants. The multivariate analysis for all the participants (adults and children), indicated that mothers were 2.6 times more likely to be adherent in giving antibiotics to their children than adults (p<0.001). These findings highlight that more than half of the participants were adherent to short-term antibiotics. However, improving the current prescription-related practices and implementing pharmaceutical consultation services upon antibiotic dispensing are encouraged.
Differential gene expression profile of multinodular goiter
Authors: de Figueiredo Wenberger Lanza Daniel , Lopes Eraldo Ferreira , Jezini Deborah Laredo , Marçal Lorena Naciff , de Assunção Enedina Nogueira , Ribeiro Rodrigues Paulo Rodrigo , José da Mota Adolfo , Carvalho Diego Monteiro de , Filho Spartaco Astolfi , Lopes Botelho João Bosco
Published: May 2022

Introduction

The goiter, a neglected heterogeneous molecular disease, remains a major indication for thyroidectomies in its endemic regions.

Objectives

This study analyzed differential gene expression in surgical specimens diagnosed with multi nodular and compared the data to that of thyroid tissue without multinodular goiter from patients undergoing thyroidectomy in Manaus-AM, Brazil using RNA-seq technology.

Methodology

The transcriptome information of the surgical specimen fragments with and without multinodular goiter was accessed by Illumina HiSeq 2000 New Generation Sequencing (NGS) using the RNA-seq NEBNext® Ultra™ RNA Library Prep Kit for Illumina®—#E7530L protocol and differential gene expression analysis.

Results

Differences were found between the gene expression profiles of the diseased tissues and those of the healthy control tissues; at least 70 genes were differentially expressed. The HOTS gene was expressed only in multinodular goiter tissues (p < 0.05).

Conclusion

These results demonstrate that the gene expression profile of multinodular goiter is pro-tumoral and that HOTS can play a central role in multinodular goiter development.
Multi-locus SNP analyses of interleukin 1 receptor associated kinases 2 gene polymorphisms with the susceptibility to rheumatoid arthritis
Authors: Ghouri Maham , Ismail Muhammad , Zaidi Syeda Areesha , Rehman Shafique , Dahani Asadullah , Saleem Saima , Zehra Sitwat
Published: May 2022

Background

The genetic polymorphisms (rs708035, rs3844283) of Interleukin-1 receptor associated kinases 2 (IRAK2) is involved in the NFκB regulatory pathway. The frequencies of IRAK2 gene are unknown in Pakistani population. Therefore, the study was designed to examine the association of targeted single nucleotide polymorphism(s) in IRAK2 gene of RA patients.

Methodology

The study participants were selected by ACR/EULAR 2010 standards. After ethical approval, the blood samples of patients and healthy controls were collected for the extraction of DNA followed by the amplification of targeted polymorphism(s) via Tetra-primer Amplification Refractory Mutation System (T-ARMS PCR). Desired products were observed via agarose gel electrophoresis.

Results

The allele frequency of wild type A and C is frequent among patients and mutant T and G is frequent among controls. The rs708035 showed significant protective association while rs3844283 was found to be associated with risk of RA. Genetic model associations were applied to determine the role of genotypes. In combination analyses of alleles revealed AC haplotype was found to be associated with risk and TG provide protection against RA. Moreover, targeted SNPs were found to be in 61% Linkage Disequilibrium among the targeted population.

Conclusions

Current study revealed the protective and risk association of targeted SNPs (rs708035, rs3844283). Study might be beneficial as it provides baseline data regarding targeted SNPs and their role in the disease progression. This could be served as potential biomarker for diagnostic purpose and effectively utilized in precision medicine approach.
Provider reported challenges with completing death certificates: A focus group study demonstrating potential sources of error
Authors: Morgan Allie , Andrew Thomas , Guerra Sylvia M. A. , Luna Valeria , Davies Louise , Rees Judy R.
Published: May 2022

Objectives

To characterize the experiences of providers in completing the cause of death section on death certificates, with particular reference to deaths in people who have cancer.

Methods

Focus groups were conducted until thematic saturation was reached, resulting in four groups over three months. Participants were from a variety of specialties and levels and types of training. Focus groups were recorded and transcribed verbatim and analyzed using constant comparison analysis.

Results

Three types of challenges to case classification were identified. 1) Infrastructural and procedural challenges encountered when completing death certificates, including the rigid structure of the form, lack of training in its completion, and lack of real-time feedback. 2) Clinical uncertainty and the varied approaches providers take to determine the cause of death based on their perception of the purpose of the death certificate. 3) Choosing cause of death in decedents with a history of cancer.

Conclusions

There are specific and substantial challenges in the death certification process that lead to errors in documenting the cause of death, but many of these challenges could be addressed with structural change to the forms or mechanism of training. Using these data to inform change could improve the death certification process and reliability of this data.
Diagnostic value of smartphone in obstructive sleep apnea syndrome: A systematic review and meta-analysis
Authors: Kim Do Hyun , Kim Sung Won , Hwang Se Hwan
Published: May 2022

Objectives

To assess the diagnostic utility of smartphone-based measurement in detecting moderate to severe obstructive sleep apnea syndrome (OSAS).

Methods

Six databases were thoroughly reviewed. Random-effect models were used to estimate the summary sensitivity, specificity, negative predictive value, positive predictive value, diagnostic odds ratio, summary receiver operating characteristic curve and measured the areas under the curve. To assess the accuracy and precision, pooled mean difference and standard deviation of apnea hypopnea index (AHI) between smartphone and polysomnography (95% limits of agreement) across studies were calculated using the random-effects model. Study methodological quality was evaluated using the QUADAS-2 tool.

Results

Eleven studies were analyzed. The smartphone diagnostic odds ratio for moderate-to-severe OSAS (apnea/hypopnea index > 15) was 57.3873 (95% confidence interval [CI]: [34.7462; 94.7815]). The area under the summary receiver operating characteristic curve was 0.917. The sensitivity, specificity, negative predictive value, and positive predictive value were 0.9064 [0.8789; 0.9282], 0.8801 [0.8227; 0.9207], 0.9049 [0.8556; 0.9386], and 0.8844 [0.8234; 0.9263], respectively. We performed subgroup analysis based on the various OSAS detection methods (motion, sound, oximetry, and combinations thereof). Although the diagnostic odds ratios, specificities, and negative predictive values varied significantly (all p < 0.05), all methods afforded good sensitivity (> 80%). The sensitivities and positive predictive values were similar for the various methods (both p > 0.05). The mean difference with standard deviation in the AHI between smartphone and polysomnography was -0.6845 ± 1.611 events/h [-3.8426; 2.4735].

Conclusions

Smartphone could be used to screen the moderate-to-severe OSAS. The mean difference between smartphones and polysomnography AHI measurements was small, though limits of agreement was wide. Therefore, clinicians should be cautious when making clinical decisions based on these devices.
Do patients’ pre-treatment expectations about acupuncture effectiveness predict treatment outcome in patients with chronic low back pain? A secondary analysis of data from a randomised controlled clinical trial
Authors: Zieger Anja , Kern Alexandra , Barth Jürgen , Witt Claudia M.
Published: May 2022

Objective

This secondary analysis of a randomised controlled patient-blinded trial comparing effectiveness and side effect briefings in patients with chronic low back pain (CLBP) investigated the association between patients’ pre-treatment expectations about minimal acupuncture treatment and pain intensity as outcome during and after the end of the treatment.

Methods

Chronic low back pain patients with a pain intensity of at least 4 on a numeric rating scale from 0 to 10 received eight sessions of minimal acupuncture treatment over 4 weeks. The primary outcome was change in pain intensity rated on a Numerical Rating Scale (NRS 0–10) from inclusion visit to treatment session 4 and to the end of the treatment. Patients’ expectations about the effectiveness of acupuncture were assessed using the Expectation for Treatment Scale (ETS) before randomization. Linear regression was applied to investigate whether patients’ pre-treatment expectations predicted changes in pain intensity during and after treatment.

Results

A total of 142 CLBP patients (40.1 ± 12.5 years; 65.5% female) were included in our analysis. Patients’ pre-treatment expectations about acupuncture treatment were associated with changes in pain intensity after four sessions of minimal acupuncture treatment (b = -0.264, p = 0.002), but not after the end of the treatment. This association was found in females and males.

Conclusions

Our results imply that higher pre-treatment expectations only lead to larger reductions in pain intensity in the initial phase of a treatment, with a similar magnitude for both females and males. As the treatment progresses in the second half of the treatment, adapted expectations or other non-specific effects might play a more important role in predicting treatment outcome.
The health impacts of the COVID-19 pandemic on adults who experience imprisonment globally: A mixed methods systematic review
Authors: Kim Hannah , Hughes Emily , Cavanagh Alice , Norris Emily , Gao Angela , Bondy Susan J. , McLeod Katherine E. , Kanagalingam Tharsan , Kouyoumdjian Fiona G.
Published: May 2022

Background

The prison setting and health status of people who experience imprisonment increase the risks of COVID-19 infection and sequelae, and other health impacts of the COVID-19 pandemic.

Objectives

To conduct a mixed methods systematic review on the impacts of the COVID-19 pandemic on the health of people who experience imprisonment.

Data sources

We searched Medline, PsycINFO, Embase, the Cochrane Library, Social Sciences Abstracts, CINAHL, Applied Social Sciences Index and Abstracts, Sociological Abstracts, Sociology Database, Coronavirus Research Database, ERIC, Proquest Dissertations and Theses, Web of Science, and Scopus in October 2021. We reviewed reference lists for included studies.

Study eligibility criteria

Original research conducted in or after December 2019 on health impacts of the COVID-19 pandemic on adults in prisons or within three months of release.

Study appraisal and synthesis methods

We used the Joanna Briggs Institute’s Critical Appraisal Checklist for Qualitative Research for qualitative studies and the Joanna Briggs Institute’s Critical Appraisal Checklist for Studies Reporting Prevalence Data for quantitative studies. We qualitized quantitative data and extracted qualitative data, coded data, and collated similar data into categories.

Results

We identified 62 studies. People in prisons had disproportionately high rates of COVID-19 infection and COVID-19 mortality. During the pandemic, all-cause mortality worsened, access to health care and other services worsened, and there were major impacts on mental wellbeing and on relationships with family and staff. There was limited evidence regarding key primary and secondary prevention strategies.

Limitations

Our search was limited to databases. As the COVID-19 pandemic is ongoing, more evidence will emerge.

Conclusions

Prisons and people who experience imprisonment should be prioritized for COVID-19 response and recovery efforts, and an explicit focus on prisons is needed for ongoing public health work including emergency preparedness.

Prospero registration number

239324.