bluuebunny/crossref_metadata_2025 huggingface dataset:
“Left Skaftymov’s ‘nest’ too early”: V. A. Bochkarev about A. P. Skaftymov
Authors:   Samara State University of Social Sciences and Education, Krivonos Vladislav Sh.
Published: September 2023

The article discusses the relationship of V. A. Bochkarev, a graduate of Saratov University in 1930, the first postgraduate student of A. P. Skaftymov in 1930–1933, subsequently Doctor of Philology, professor, the head of the department of the Russian and Foreign literature of Kuybyshev (Samara) Pedagogical Institute (University) for many years, the author of the fundamental works on the Russian historical drama, and A. P. Skaftymov, the founder and the creator of Saratov School of Philology, a scientist of world renown. A. P. Skaftymov left philological legacy exclusively valuable in its scientific magnitude and he educated many students, the nestlings of Skavtymov’s “nest”, as they were called afterwards, some of them, including V. A. Bochkarev, have taken the rightful place in the literature science. The article covers the important role that A. P. Skaftymov played in the personal and scientific life of V. A. Bochkarev in his formation as a scientist and a teacher, who retained a grateful memory of his tutor. Some important memoir evidence by V. A. Bochkarev is presented, in which he dwells on the content and structure of the lecture courses given by A. P. Skaftymov, that V. A. Bochkarev chanced to attend as a student and a postgraduate, on the topics of the special seminars that A. P. Saftymov used to teach, on the reports that were prepared under his supervision, on the requirements of the scientific supervisor to the students’ and postgraduates’ papers, on the methods of scientific counselling, on A. P. Skaftymov’s inherent feeling of democracy, that was revealed in his behavior as the head of the department and the faculty. The article considers how V. A. Bochkarev perceived and evaluated the scientific, moral and educational lessons of A. P. Skaftymov, which he appropriated for his life and reflected in his memories and letters to his colleagues in Saratov.
Next-generation sequencing panel test results in pediatric patients with progressive familial intrahepatic cholestasis: a single-center experience
Authors: TOPAK Ali
Published: September 2023

Objective: The aim of this study is to reveal the diagnostic yield of the progressive familial intrahepatic cholestasis (PFIC) gene panel that we have used in the diagnosis of this patient group, which accounts for approximately 10% of cholestatic liver disease, and to report the clinical findings of our patients with the detected variants.
Methods: In this study, we retrospectively evaluated the results of molecular genetic analysis of pediatric patients whose PFIC gene panel contained the ATP8B1, ABCB11, and ABCB4 genes.
Results: In 10 patients, 12 different variants were detected that could explain the PFIC clinical picture. Three of these variants were considered novel variants.
Conclusion: Our study demonstrates the usefulness of the NGS panel in diagnosing pediatric patients with PFIC findings. This diagnostic method also contributed to the variant spectrum of PFIC-related genes.
Enhancement of physical-mechanical properties of natural wood by doping with nanoparticles of zinc oxide
Authors:   Voronezh State University of Forestry and Technologies named after G.F. Morozov», Khodosova N.A. , Tomina E.V. ,   Voronezh State University of Forestry and Technologies named after G.F. Morozov», Novikova L.A. ,   Voronezh State University of Forestry and Technologies named after G.F. Morozov», Dmitrenkov A.I. ,   Voronezh State University of Forestry and Technologies named after G.F. Morozov»
Published: September 2023

The results of investigating the effect of ZnO nanoparticles in the structure of natural wood of silver birch on its physical-mechanical properties were presented. The possibility of synthesis of nanosized ZnO particles within the cavities of wood after ultrasound activated impregnation of an amorphous Zn(OH)2 gel into wood and subsequent drying at 110 oC was established. It was found out that doping with nanosized ZnO contributed hydrophobization of natural birch wood. It was observed that moisture absorbance of the wood doped with ZnO decreased in 4 times, water absorbance — by 30 % and swelling in radial and tangential directions — in 3,5 and 6 times correspondingly. An increase in the contact angle of wetting in 3,5 times was determined.
Determination of forest logging road visibility by ground-based stereophotogrammetry
Authors:   Bryansk State Engineering Technological University, Tikhomirov P.V. , Skrypnikov A.A. ,   Voronezh State University of Engineering Technologies, Volodina Yu.Yu. ,   Voronezh State University of Engineering Technologies, Borovlev Yu.A. ,   Voronezh State University of Engineering Technologies, Kartavtsev O.L. ,   Voronezh State University of Engineering Technologies, Mirzoev D.D. ,   Voronezh State University of Engineering Technologies
Published: September 2023

The article describes a method for determining the visibility on the roundings of logging roads based on the materials of ground-based photo and video recording. The essence of this method is to compare the spatial photogrammetric coordinates of the points of the visibility zone. The obstacle zone and the visibility zone are considered in the same photogrammetric coordinate system, and the design center of this system coincides with the left end of the photovideo recording basis. Studies are given to determine the magnitude of the visibility distance on the horizontal curves of logging roads in the presence of an obstacle in relation to the normal case of shooting. Measures to improve traffic conditions on the roundings of logging roads in the event of a complete or partial lack of visibility are also considered. In the course of the research, dependences were obtained to determine the value of the visibility distance by the method of ground-based stereophotogrammetry, in relation to horizontal curves in the road plan; the assessment of the accuracy of determining the distance of visibility based on the materials of ground-based stereophotogrammetry was carried out. In the case of lack of visibility on the horizontal curves of roads, dependencies are proposed to determine the area and volume of the cut, and dependencies are established to assess the accuracy of the measurements performed.
Larix decidua radial increments dynamics under anthropogenic impact
Authors:   Institute of Forest Science RAS, Rybakova N.A. , Glazunov Yu.B. ,   Institute of Forest Science RAS
Published: September 2023

The results of a dendrochronological analysis of the European larch (Larix decidua Mill.) forest plantations growth in the zone of influence of motor transport pollution in the territory near the Moscow Ring Road at a distance of 8 and 18 m from the roadbed and in a recreational plantation in the third stage of digression are presented. The influence of these factors at the age of European larch from 5 to 65 years was revealed. It has been established that in plantations near the Moscow Ring Road, the annual radial growth of European larch wood is on average 45 %, in a plantation with a recreational load it makes up 62 % of the increase in the control plot, remote from highways and settlements. Differences in annual increments are statistically significant throughout the entire observation period. The average long-term growth of wood at a distance of 8 m from the Moscow Ring Road is 34 % lower than at a distance of 18 m. With an increase in the distance from the roadbed by 1 m, the annual growth of wood increases by 0,2 mm. In forest plantations of European larch, growths of early wood predominate: in areas near the Moscow Ring Road — an average of 68 % of the annual growth, in a plantation with a recreational load — 63 %, in the control plot — only 49 %.
Telepraca – ujęcie definicyjne, poruszane problemy i zalecenia na przyszłość
Authors: Hauk Mateusz
Published: September 2023

The aim of this article is to describe the notion of telework and show the most popular aspects of telecommuting. Detailed review of the literature points out that there is no one, widely accepted definition of telework. Thus, for the purpose of this article, telecommuting is defined as “Every sort of money-gained activity, caused by external motivation of the individual and/or induced by the organization, no matter what is the extent of time spent on teleworking. What is very important is the fact that teleworking is connected with fulfilling the obligations in a flexible way, outside the conventional workplace, with the use of available telecommunications or computer-based technology to transport it’s effects”. Further investigation of the literature shows that 3 aspects are being the most popular among telework researchers: 1) demographic and psychological characteristic of telecommuting individuals, 2) causes of teleworking, 3) outcomes of teleworking, such as: increased productivity, organizational loyalty, satisfaction and high morale, decreased level of stress and positive work-life balance. Majority of the surveys have got plenty of methodological limitations, thus the results are not to be generalized on wider population. Moreover, obtained data varies in different studies, so that telework with all it’s aspects needs further investigation. At the end of the article there are proposed new directions for the future research.
Trudna miłość: płeć niepełnosprawnego dziecka a psychospołeczne funkcjonowanie jego matki
Authors: Masłowiecka Agnieszka
Published: September 2023

Motherhood is a special kind of love, that connects with the child’s sex. We would like to think, that the relationship is unconditional, but having a child relates to some consequences and causes some projections, expectations, isn’t neutral. What happens when a child – equipped in particular gender – has a mental disability? What are the mothers feelings, how does she behave, when she is a mother of handicapped boy or a girl? This work contains the results of researches of psychosocial function of 115 mothers of handicapped children. Relationships between sex, coping, collective self-esteem of mothers and their personal self-esteem, social anxiety, consciousness of stigma (stereotypisation) was analyzed in this study. Results revealed, that child’s sex is meaningful for the mother. Mothers of handicapped sons have more problems than girl’s mothers. They have lower level of personal self-esteem, higher social anxiety, they show strong identification with the category of disability, feel worse in groups, prefer avoiding ways of coping, their attitude to the child’s therapy is negative.
Forget worldviews: Towards a Deleuzian religious studies
Authors: Tremlett Paul-François
Published: September 2023

In this essay I engage in a close analysis of three documents central to the push to place the worldview concept at the front and centre of Religious Studies in schools and universities - the 2018 Commission on Religious Education Report Religion and Worldviews: The Way Forward, Worldview: A Multidisciplinary Report(2020) and The Worldview Project: Discussion Papers (2020). I argue that the documents paint a picture of a subject caught between an objectivist account of a fixed field of really existing religions and a postmodern or Deleuzian mélange of lived interactions and flows. I advocate for a Deleuzian transformation of Religious Studies and the embrace of decolonisation and critical religious literacy, based in a vision of the study of religions as the study of relations and assemblages.
Engaged Research in the Study of Religion
Authors: Chryssides George David
Published: September 2023

The author contends that there is a need for greater engagement in research in the study of religion, drawing on his own experiences of engagement, involving the Information Network Focus on Religious Movements, relations with the media, acting as an expert witness in litigation, and participation in events which are sponsored and financed by religious organisations. Scholars frequently feel the need to “pay back” the communities they study on account of their cooperation and provision of data. This can be done by ensuring that publication is fair and accurate, while at the same time being vigilant that undue involvement and acceptance of hospitality does not prevent the maintenance of critical distance in one’s writing. Responding to individual enquiries about one’s work is also discussed. It is concluded that there is a need to consider whether one’s work is for one’s own benefit, or for the wider community outside academia, and that the aims of the study of religion need to be defined to reflect scholarly engagement with societal issues.
Deforestación de la costa peruana: rasgos de un proceso secular
Authors: Seiner-Lizárraga Lizardo
Published: September 2023

El presente artículo identifica los factores principales que más directamente han incidido en el proceso de deforestación costeña dentro de una escala secular. Cinco son los factores que pueden identificarse como generadores del deterioro forestal costeño: uso doméstico para construcción y empleo de leña para cocción de alimentos; uso de madera en las actividades mineras y metalúrgicas; y empleo en la construcción naval y de transporte terrestre, con la llegada y difusión de los ferrocarriles.
Standard Model in the early Universe
Authors: Gromov N.
Published: September 2023

A new hypothesis is put forward that the gauge group of the

Standard Model becomes simpler with increasing temperature

of the Universe, i.e. when moving back in time to the moment

of its occurrence. It is assumed that this simplification

is achieved by contracting the gauge group with the contraction

parameter, which decreases with increasing temperature.

In this case, the Lagrangian of the Standard Model is

divided into terms that differ in powers of the contraction parameter.

This makes it possible to arrange in time the stages

of development of the Standard Model as the Universe cools.

The evolution of the properties of elementary particles and

their interactions, starting from the Planck scale of 1019 GeV,

is based on the explicit form of intermediate Lagrangians and

explain the development of the Universe from simpler to more

complicated structures - and not vice versa. The contraction

hypothesis of the gauge group of the Standard Model contradicts

the available experimental data on the Higgs boson production

cross section.
Tensor extensions of Lax equations
Authors: Karabanov A.
Published: September 2023

The Lax equations dL/dt = [M,L] play an important role in

the integrability theory of nonlinear evolution equations and

quantum dynamics. In this work, tensor extensions of the

Lax equations are suggested with M : V → V and L :

Tk(V ) → V , k = 1, 2, . . ., on a complex vector space V .

These extensions belong to the generalised class of Lax equations

(introduced earlier by Bordemann) dL/dt = ρk(M)L

where ρk is a representation of a Lie algebra. The case k = 1,

ρ1 = ad corresponds to the usual Lax equations. The extended

Lax pairs are studied from the point of view of isomorphic

deformations of multilinear structures, conservation

laws, exterior algebras and cochain symmetries.
On classical and quantum mechanical problem of two material points in three-dimensional Lobachevsky space
Authors: Kurochkin Yu. , Shaykovskaya, N. , Shelkovyy D.
Published: September 2023

The classical and quantum problems of motion of two particles in a three-dimensional Lobachevsky space is formulated with respect to center of mass with arbitrary position. The Hamilton-Jacobi and Schrödinger equations of the problem are formulated and their solutions are found. It is shown that the reduced mass of the system depends on the relative distance. The classical and quantum problems of a rigid rotator in three-dimensional sphere and Lobachevsky space are formulated and solved. The dependences of the oscillation periods of the rotator on the ratio of the masses of the particles forming it are studied for a fixed total mass in the cases of spaces of constant curvature.
ENTREPRENEUR’S ROLES DURING BUSINESS GROWTH STAGE AND THEIR EXIT ROUTES: THE CASE OF THE PUBLIC RELATIONS INDUSTRY [PERAN PENGUSAHA DALAM TAHAP PERTUMBUHAN BISNIS DAN RUTE KELUAR DARI BISNIS TERSEBUT: KASUS INDUSTRI PUBLIC RELATIONS]
Authors: Ly-Le Tuong-Minh , Le Viet Tho
Published: September 2023

This research article aims to examine the entrepreneur’s roles during the business growth stage and their exit routes, with a focus on the public relations industry in Vietnam. The findings highlight the transition of entrepreneurs from hands-on involvement in all aspects of the business to assuming strategic roles during the growth stage. Founders play a crucial role in setting the company’s vision, establishing a solid organizational culture, and fostering innovation. The decision of whether to maintain control or delegate management responsibilities is critical, with some entrepreneurs choosing to retain control due to their emotional attachment, while others recognize the need to delegate to professional managers.

Abstrak dalam Bahasa Indonesia. Artikel penelitian ini bertujuan untuk mengkaji peran pengusaha selama tahap pertumbuhan bisnis dan rute keluarnya, dengan fokus pada industri hubungan masyarakat di Vietnam. Temuan menyoroti transisi pengusaha dari keterlibatan langsung dalam semua aspek bisnis untuk mengambil peran strategis selama tahap pertumbuhan. Pendiri memainkan peran penting dalam menetapkan visi perusahaan, membangun budaya organisasi yang solid, dan mendorong inovasi. Keputusan apakah akan mempertahankan kendali atau mendelegasikan tanggung jawab manajemen sangat penting, dengan beberapa pengusaha memilih untuk mempertahankan kendali karena keterikatan emosional mereka, sementara yang lain menyadari kebutuhan untuk mendelegasikan kepada manajer profesional.
Freezing Time Calculation of the Above-Ground Water Pipeline Under Conditions of Negative Temperatures
Authors: Lapshin Vladimir
Published: September 2023

Purpose: When the water movement in the pipeline is stopped in conditions of negative temperatures, its freezing and destruction are possible, which leads to the failure of water supply systems for a long time. For accident-free operation of the water pipeline, it is important to know the time during which its complete or partial freezing occurs. The purpose of this work is to study the physical processes that occur during freezing, to formulate the basic mathematical model and its numerical solution, to build an analytical solution in a quasistationary approximation, to obtain formulas that are convenient for freezing time calculation and to determine the range of parameter values at which they are valid. Methods: The mathematical model of the freezing process relies on the use of energy conservation law. When constructing a difference scheme, the integrointerpolation method is used to numerically solve the nonlinear differential equations of the model. To obtain an approximate analytical solution, the method of separating equations describing processes that occur at different speeds, is used. Results: The mathematical model of pipeline freezing during water movement shutdown under conditions of constant negative temperature of the surrounding atmosphere has been formulated and substantiated. Within the framework of the quasi-stationary approximation, simple formulas for the freezing time of the water pipeline have been obtained. The criteria for the applicability of these formulas have been established. The numerical solution of equations of initial mathematical model is compared with the results obtained within quasi-stationary approximation. Practical significance: The ratios obtained in the work make it possible to estimate the time during which repair work should be carried out and the movement of water in the pipeline should be restored before its destruction due to freezing occurs.
Dermatofibrosarcoma protuberans de mama con reconstrucción con colgajo del dorsal ancho. Reporte de caso
Authors: Guevara Pacheco Jhon
Published: September 2023

El Dermatofibrosarcoma Protuberans es un tumor cutáneo fibrohistiocítico, extremadamente raro y representa menos del 1% de los tumores mamarios. Se caracteriza por un lento crecimiento, pero con comportamiento infiltrante con altas tasas de recidiva local. Se puede sospechar clínicamente, la confirmación es histopatológica y se debe complementar con inmunohistoquímica. El tratamiento de elección es quirúrgico. Se presenta el caso de una mujer de 23 años con Dermatofibrosarcoma Protuberans de mama derecha, sometida a tumorectomía y reconstrucción inmediata de colgajo de dorsal ancho.  La paciente tuvo evolución satisfactoria, sin evidencia de enfermedad.
MULTIPHASIC SCREENING: CLINICAL SYMPTOMS AND MENTAL HEALTH PATIENT TUBERCULOSIS IN JAMBI CITY, INDONESIA
Authors: Izhar M. Dody , Wardiah Rizalia , Lanita Usi , Herwansyah
Published: September 2023

Background: Multiphasic screening with GeneXpert MTB/RIF and PHQ-9 is a solution for achieving successful conversion of intensive phase sputum examination. Purpose: To determine the effectiveness and feasibility of multiphasic screening for clinical symptoms and mental health in patients using the Tuberculosis Directly Observed Therapy (TB-DOTS) strategy. Methods: This study used a survey approach with a one-sample multiple testing screening method on the case finding and mental health of patients with TB. This screening was carried out in two stages: Stage I, suspected TB screening, and Stage II, mental health screening of TB patients undergoing intensive treatment (two months). Samples were taken from 160 TB suspects who came to health centers in Jambi City from August 1 to October 1, 2022, using proportionate stratified random sampling. Data were analyzed using statistical software to determine the accuracy and feasibility of screening. Results: Sputum conversion (Smear [-]) was 97.78% and the prevalence of mental health problems in patients was 22.22%. Stage I screening (suspected TB [GeneXpert MTB/RIF]): cough >2 weeks sensitivity, 94.84%; PPV, 97.35%; and accuracy, 92.50%. Stage II screening (patient mental health [PHQ-9]) with a validity of 9 items in the range of 0.17-0.66; ICC (interclass correlation coefficient [ICC], 0.60-0.83; Cronbach's a coefficient, 0.88). Multiphasic yield screening is recommended to achieve a better treatment success rate. Conclusion: Early detection of cases and mental health problems of TB patients in the early phase of treatment is a solution for developing a TB-DOTS strategy at first-level health facilities.
AN EPIDEMIOLOGICAL OVERVIEW OF DENGUE HEMORRHAGIC FEVER (DHF) CASES IN KEDIRI REGENCY DURING 2017-202
Authors: Amalia Febrianti Faradillah , Qurniyawati Eny , Atoillah Isfandiari Muhammad , Mohamed Gomaa Nasr Nayla
Published: September 2023

Background: Dengue Hemorrhagic Fever (DHF) is a communicable disease with rapid spread and the potential to cause death. In 2019, Kediri District had the fourth-highest number of DHF cases in East Java Province and was reported to have experienced a DHF outbreak. Objective: This study aimed to describe dengue cases in Kediri District in 2017-2021 under non-pandemic and COVID-19 pandemic conditions. Methods: Using a total sampling technique, descriptive research with a case series design was conducted using secondary data from the Health Profiles and the Central Bureau of Statistics of Kediri District in 2017-2021. The studied variables included the number of dengue cases, sex, age, area, population, population density, morbidity rate, Lateral Flow Immunoassay (LFI), and rainfall. Data were analyzed using an epidemiological approach based on people, places, and times and visualized with tables and diagrams. Results: The majority of DHF cases occurred in males and the 5-14 years age group in both the COVID-19 non-pandemic (52.88%; 55.96%) and COVID-19 pandemic conditions (51.14%; 58.56%). The incidence rate (IR) increased with population density and the number of dengue cases in the non-COVID-19 pandemic. It decreased with a decrease in dengue cases when the population density increased during the COVID-19 pandemic. Under all conditions, high dengue cases were found in months with high rainfall. Conclusion: The pattern of DHF incidence in Kediri District in 2017-2021 is mostly in males and the age group of 5-14 years, when there is an increase in population density, and in January.
ANALYSIS OF DOMINANT RISK FACTORS FOR HYPERTENSIVE DISEASE
Authors: Bastira Ginting Johannes , Suci Tri
Published: September 2023

Background: Hypertension is a non-communicable disease with a high morbidity and mortality rate. This disease frequently triggers the iceberg phenomenon as numerous individuals remain unaware of the affliction. Aim: This study determines the most dominant risk factors for the incidence of hypertension. Methods: The quantitative study method used was conducted in September 2022. The study population utilized secondary data sourced from the Visit data at the Johar Baru Health Center in South Jakarta during 2021. The initial dataset consisted of 102,647 patients, out of which 13,946 had hypertension. Furthermore, data analysis involved employing the Chi-square test and Multiple Logistic Regression, with a significance level of 95%. Results: The Chi-Square test yielded significant results, indicating a relationship between risk factors for hypertension and seven out of the nine free variables examined. These variables included Body Mass Index (BMI) (p-value=0.000), excess salt consumption (p-value=0.000), underfeeding fruits and vegetables (p-value=.000), lack of physical activity (p-value=0.000), excess fat consumption (p-value=0.000), gender (p-value=0.000), and age (p-value=0.000), with a p-value of <0.05. Meanwhile, smoking (p-value=0.516) and drinking alcohol (p-value=0.859) variables, with a p-value of >0.05 had no relationship. Conclusion: The result showed that BMI was the most dominant risk factors for hypertension, with an OR of 1,610. Therefore, people with an abnormal BMI have a 1,610 times risk of developing hypertension.
THE EFFECT OF COMORBIDITIES ON MORTALITY IN COVID-19 PATIENTS IN dr RADEN SOEDARSONO HOSPITAL PASURUAN
Authors: Puspita Kencana Lidia , Diah Kartiningrum Eka , Mafticha Elyana
Published: September 2023

Background: COVID-19 patients with comorbidities have the highest mortality risk in Indonesia during the pandemic. Purpose: This study purposed to determine the prevalence of comorbidities on mortality of COVID-19 patients at RSUD dr. Raden Soedarsono, Pasuruan.  Methods: This study used a case-control design with 560 samples collected from January until December 2021. The samples consisted of 140 COVID-19 patients who were treated at RSUD dr. Raden Soedarsono, Pasuruan, in 2021 and declared dead as a case group, as well as 420 COVID-19 patients treated at RSUD dr. Raden Soedarsono, Pasuruan, in 2021 but did not die as a control group. The data were then analyzed using a logistic regression test with SPSS 22.0. Results: The results show that almost all COVID-19 patients did not have comorbidities of diabetes mellitus (85.50%), autoimmune (98.60%), kidney disease (98.20%), gastrointestinal diseases (92.10%), thrombosis and coagulation disorders (93.60%), myocardial injury (99.30%), heart failure (94.30%), hypertension (95.20%), and tuberculosis (5.70%). Also, almost all COVID-19 patients did not have comorbidities of geriatrics (71.60%), COPD (64.10%), and mortality status (25.00%). The results of the logistic regression test show that comorbidities of diabetes mellitus (P-value 0.01; OR 1.99) and geriatrics (P-value 0.00; OR 2.82) affect mortality in COVID-19 patients. Whereas comorbidities of autoimmune (P-value 0.84), kidney disease (P-value 0.37), gastrointestinal diseases (P-value 0.73), thrombosis and coagulation disorders (P-value 0.24), myocardial injury (P-value 0.84), heart failure (P-value 0.43), hypertension (P-value 0.93), COPD (P-value 0.86), and tuberculosis (P-value 0.15) do not affect mortality inCOVID-19 patients. Conclusion: Diabetes Mellitus and geriatrics are the most significant comorbidities in causing the death of COVID-19 patients at RSUD dr. Raden Soedarsono, Pasuruan.
MAPPING SPREAD OF COVID-19 CASES IN TODDLERS AND CHILDREN AT CENTRAL JAVA USING K-MEANS CLUSTER
Authors: Widianawati Evina , Ratna Wulan Widya , Tri Wahyuni Anis , Agiwahyuanto Faik
Published: September 2023

Background: Toddlers and children under 12 are still easily sick, particularly during the COVID-19 epidemic. The high number of COVID-19 cases in toddlers and children in Central Java Province must be monitored to prevent transmission to toddlers and children still susceptible to the disease. Purpose: The purpose of this study was to map the spread of COVID-19 cases in toddlers aged 0-5 years and children aged 6-11 years in the province of Central Java using the K-means cluster Methods: This was a descriptive observational study with a cross-sectional design. Data on COVID-19 cases in children 6-11 years and toddlers 0-5 years from 35 cities in Central Java in 2020-2021 were analyzed using the K-means cluster. The K-means cluster was used to cluster low, medium, and high cases and then map the spread of COVID-19. Results: Semarang, Semarang Regency, Boyolali, Klaten, Surakarta, and Banyumas became high cluster areas in cases of COVID-19 toddlers and children in 2021. Based on the mapping data, COVID-19 spread in young children and toddlers in 2020 and 2021 followed a nearly identical pattern. The high zone of COVID-19 in toddlers and children mostly had a higher total population, healthcare facilities, and population density than the medium and low zones. Conclusion: Semarang City, Semarang Regency, Boyolali, Klaten, Surakarta, and Banyumas should be looking for COVID-19 cases in toddlers and young children.
Concise review: Breastfeeding, lactation, and NAFLD. An updated view of cross-generational disease transmission and prevention
Authors: Lonardo Amedeo , Suzuki Ayako
Published: September 2023

Evidence suggests that breastfeeding protects the mother-infant dyad against the development and progression of nonalcoholic fatty liver disease (NAFLD). In this context, we aim to provide insight into the most notable and representative epidemiological studies published in the literature. Furthermore, we will delve into the potential underlying pathomechanisms that might be involved in this relationship. The current definitions of breastfeeding, lactation, mother-infant dyad, and nonalcoholic fatty liver disease (NAFLD) are provided. Next, the epidemiological evidence supporting potential benefits for the (long-term) lactating mother in terms of protection from the development and progression of NAFLD is reviewed. The putative mechanisms underlying this protection are also analyzed. Similarly, clinical and epidemiological studies evaluating the benefits of breastfeeding for the offspring are examined, together with a discussion of the putative underlying mechanisms. In conclusion, our understanding of breastfeeding (for the offspring) and lactation (for the mother) as protective factors from NAFLD development and fibrotic progression will provide further insight into unprecedented disease mechanisms shared by the mother-infant dyad promising to interrupt the vicious cycle of NAFLD transmission across generations.
Simple waves and small perturbations in radiative gas dynamics
Authors: Kolesnichenko Aleksandr Vladimirovich
Published: September 2023

The paper analyses one-dimensional simple waves and small-amplitude disturbances in radiating and scattering grey gas. The governing equation of radiation acoustics describing the dynamics of simple waves is derived. Radiation-thermal dissipation conditions and radiation resistance force are introduced into this equation to describe the propagation and attenuation of various radiation perturbation waves. To study non-equilibrium wave phenomena in a radiating medium, the phenomenological Whitham method is used. This method is an effective way to analyse fundamental modes when more than one velocity appears in the governing equation. The use of this method is demonstrated in the paper by considering the evolution of one-dimensional harmonic waves caused by a short-wave initial perturbation of the equilibrium state of the radiating and scattering medium. For all wave modes, analytical solutions have been obtained, which allow us to understand their physical significance. These solutions can be, in particular, an additional test for radiative hydrodynamic codes operating in the radiative acoustics regime. The general approach can be useful in the development of higher-order Godunov numerical schemes for radiation hydrodynamics problems.
Tataran Homologi dalam Mantra Tradisi Lokal “Toron Tana” Masyarakat Desa Lancar Kecamatan Larangan Kabupaten Pamekasan
Authors: Islam Moh. Fajrul , Faqih Fiyan Ilman
Published: September 2023

Mantra adalah salah satu bentuk karya sastra lisan yang terdapat pada sebuah tradisi toron tana masyarakat desa lancar kecamatan larangan kabupaten pamekasan. matra tersebut menjadi suatu ayat atau ikrar dalam setiap penyelenggaraan tradisi masyarakat yag diyakini sebagai titah atau pengikraran terhadap objek tradisi yakni seorang bayi. Tinjauan analisis mantra tersebut menggunakan teori strukturalisme Levi-strauss. Adapun tujuan penelitian ini yaitu mengetahui tataran homologi dalam mantra tradisi toron tana masyarakat desa lancar kecamatan larangan kabupaten pamekasan. Metode penelitian yang digunakan ialah kualitatif deskriptif. Penelitian ini menggunakan sumber data berupa kandungan mantra tradisi toron tana yang akrab dikenal oleh masyarakat dengan nama mantra panyuwunan. Teknik pengumpulan data yang dilakukan ialah pengamatan, wawancara, dokumentasi, dan transkipsi. Adapun teknis analisis data yang digunakan yakni reduksi data, penyajian data, dan penarikan simpulan. Tataran homologi dalam mantra ditemukan enam pokok data dihasilkan dari tinjauan penggunaan teori Levi Strauss.Kata kunci: Tataran Homologi, Mantra, Toron Tana
T817MA regulates mitochondrial dynamics via Sirt1 and Arc following subarachnoid hemorrhage
Authors: Chen Wei-Wei , Sun Fu-Qiang , Wang Bo , Tian Xiao-Xiao , Zhang Rong-Ping , Liu Wen-Bo , Chen Tao
Published: September 2023

Spontaneous subarachnoid hemorrhage (SAH) is an acute neurologic emergency with poor outcomes, and mitochondrial dysfunction is known as one of the key pathological mechanisms underlying the SAH-induced early brain injury (EBI). 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl} azetidin-3-ol maleate (T817MA) is a newly synthesized neurotrophic compound that has been demonstrated to exert protective effects against brain injury. Here, we investigated the effect of T817MA in neuronal injury following experimental SAH both in vitro and in vivo. Primary cultured cortical neurons were treated with oxyhemoglobin(OxyHb) to mimic SAH in vitro, and T817MA at concentrations higher than 0.1 μM reduced OxyHb-induced neuronal injury. T817MA treatment significantly inhibited lipid peroxidation, reduced neuronal apoptosis and attenuated mitochondrial fragmentation. The results of western blot showed that T817MA markedly reduced the expression of mitochondrial fission proteins, fission protein 1 (Fis-1) and dynamin-related GTPase-1 (Drp-1), but prolonged the expression of the postsynaptic protein activity-regulated cytoskeleton-associated protein (Arc). In addition, T817MA significantly increased the expression of sirtuin 1 (Sirt1), which was accompanied by preserved enzymatic of isocitrate dehydrogenase (IDH2) and superoxide dismutase (SOD). Knockdown of Sirt1 and Arc via small interfere RNA (siRNA) transfection partially prevented the T817MA-induced protection in cortical neurons. Furthermore, treatment with T817MA in vivo significantly reduced brain damage and preserved neurological function in rats. The decreased expression of Fis-1 and Drp-1, as well as the increased expression of Arc and Sirt1 were also observed in vivo. Taken together, these data indicate that the neuroprotective agent T817MA protects against SAH-induced brain injury via Sirt1- and Arc-mediated regulation of mitochondrial dynamics.
The Metabolome-Wide Signature of Major Depressive Disorder
Authors: Jansen Rick , milaneschi yuri , Schranner Daniela , Kastenmüller Gabi , Arnold Matthias , Han Xianlin , Dunlop Boadie , Rush A , Kaddurah-Daouk Rima , Penninx Brenda
Published: September 2023

Major Depressive Disorder (MDD) is an often-chronic condition with substantial molecular alterations and pathway dysregulations involved. Single metabolite, pathway and targeted metabolomics platforms have indeed revealed several metabolic alterations in depression including energy metabolism, neurotransmission and lipid metabolism. More comprehensive coverage of the metabolome is needed to further specify metabolic dysregulation in depression and reveal previously untargeted mechanisms. Here we measured 820 metabolites using the metabolome-wide Metabolon platform in 2770 subjects from a large Dutch clinical cohort with extensive depression clinical phenotyping (1101 current MDD, 868 remitted MDD, 801 healthy controls) at baseline and 1805 subjects at 6-year follow up (327 current MDD, 1045 remitted MDD, 433 healthy controls). MDD diagnosis was based on DSM-IV psychiatric interviews. Depression severity was measured with the Inventory of Depressive Symptomatology self-report. Associations between metabolites and MDD status and depression severity were assessed at baseline and at the 6-year follow-up. Metabolites consistently associated with MDD status or depression severity on both occasions were examined in Mendelian randomization (MR) analysis using metabolite (N=14,000) and MDD (N=800,000) GWAS results. At baseline, 139 and 126 metabolites were associated with current MDD status and depression severity, respectively, with 79 overlapping metabolites. Six years later, 34 out of the 79 metabolite associations were subsequently replicated. Downregulated metabolites were enriched with
long-chain monounsaturated (P=6.7e-07) and saturated (P=3.2e-05) fatty acids and upregulated metabolites with lysophospholipids (P=3.4e-4). Adding BMI to the models changed results only marginally. MR analyses showed that genetically-predicted higher levels of the lysophospholipid 1-linoleoyl-GPE (18:2) were associated with greater risk of depression. The identified metabolome-wide profile of depression (severity) indicated altered lipid metabolism with downregulation of long-chain fatty acids and upregulation of lysophospholipids, for which causal involvement was suggested using genetic tools. This metabolomics signature offers a window on depression pathophysiology and a potential access point for the development of novel therapeutic approaches.
Comparative variability of nutrients, minerals, phenolics and anthocyanins with antioxidant potentials during fruit development stages in five Mulberry (Morus) cultivars
Authors: Saeed Asma , Kauser Shabana , Hussain Adil , Nadeem Abad Ali
Published: September 2023

BACKGROUND: The versatility of mulberry from the Morus genus is growing among various suppliers and users globally. OBJECTIVES: To assess the variations in total sugar, acidity, minerals, phenolics and anthocyanins and antioxidant dynamics of three black mulberry (Morrus serrata, M. nigra and M. macroura black) and two white mulberry cultivars (M. alba and M. macroura white) during development stages. METHODS: Total sugars and titratable acidity were evaluated with AOAC methods and TPC was estimated with folin-ciocalteau method. The antioxidant activity was determined with DPPH assay, minerals were quantified with atomic absorption spectroscopy and anthocyanins were assessed with pH differential assay and identified with HPLC and LC-MS. RESULTS: Over all, M. alba (white cultivar) displayed maximum sugar (1.35%) at development stage 3 (FDS-3) followed by M. serrata (black cultivar) at FDS-5 (1.1%) and M. macroura white (white cultivar) at FDS-4 (0.9%). A decreasing trends in acidity in M. alba (0.8-0.09%), M. nigra (0.8-0.03%) and M. macroura white (0.6-0.04%) were observed during development. TPC was maximum (590 GAE/100g) in M. nigra at FDS-6 and M. serrata (450 GAE/100g) at FDS-7. Two black cultivars (M. serrata and M. nigra) showed significant increase in total anthocyanins (14.57-100.06 and 14.13-201.87 CGE/100g FW) from FDS-1 to FDS-7 while decrease in M. macroura black and M. macroura white (17.07-11.79 and 9.03-2.68) from FDS-1 to FDS-7. The DPPH inhibition of black mulberry cultivars was pointedly greater with elevated levels of Fe, Cu, Zn, Ca, Mg, Na, P and K than white cultivars during maturity. HPLC and MS procedures identified various anthocyanins in all mulberry cultivars including cyanidin, cyanidin rutinoside, mono glucosides of malvidin, pelargonidin and delphinidin. CONCLUSIONS: The selection of mulberries with improved nutrition, acceptable range of metals, bioactive compounds and higher antioxidant potentials could be a significant natural cure against health related complications such as diabetes and other metabolic syndromes.
Arbuscular mycorrhizal fungi, phosphate-solubilizing bacteria, and zinc foliar application improve physiological responses in black cumin (Nigella sativa) under drought stress
Authors: Rafiee Somayeh , Yadavi Alireza , Dehnavi Mohsen Movahhedi , Balouchi Hamidreza
Published: September 2023

This research aimed to improve the physiological response of Nigella sativa to drought stress using arbuscular mycorrhizal fungi, phosphate-solubilizing bacteria, and zinc foliar application. The results demonstrated that the reduction in irrigation water significantly impacted photosynthetic pigments, relative water content, electrolyte leakage, proline content, leaf-soluble sugars, soluble proteins, biological yield, and grain yield. In addition, in 2018 and 2019 years elevated drought stress decreased total chlorophyll (63 and 71%), carotenoids (59 and 59%), relative water content (22 and 25%), soluble proteins content (34 and 35%), biological performance (48 and 55%), and grain yield (66 and 67%). Furthermore, it increased electrolyte leakage (112 and 104%), proline (128 and 120%), and soluble sugars content (44 and 38%). The combined use of arbuscular mycorrhizal fungus (AMF) and Phosphate barvar-2 bio-fertilizer (PB2) (containing two types of phosphate-solubilizing bacteria: Pseudomonas putida P13 and Pantoea agglomerans P5) alleviated for the decrease in the measured traits. Consequently, applying bio-fertilizer increased biological performance (59 and 60%) and grain yield (58 and 58%) and decreased electrolyte leakage (34 and 31%) compared to no bio-fertilizer application. Moreover, the combination of AMF and PB2 increased the grain nitrogen (66 and 40%) and grain phosphorus (27and 36%). Zinc foliar application increased grain elements content, photosynthesis pigment, proline, soluble sugars content, soluble protein content, relative water content and biological performance. Furthermore, it decreased electrolyte leakage. Bio-fertilizers and zinc foliar application mitigated the detrimental effects of drought stress on the quality, grain yield, and biological performance of black cumin by improving the physiological mechanisms.
Vaginal axis on MRI after laparoscopic pectopexy surgery: a controlled study
Authors: sahin fatih , bayraktarli recep yılmaz
Published: September 2023

Background
Laparoscopic pectopexy has emerged as a feasible alternative to sacrocolpopexy (SCP) for treating female genital apical prolapse. Although several previous studies have reported changes in the vaginal axis in women who have undergone SCP, laparoscopic lateral mesh suspension, sacrospinous ligament fixation surgery for prolapse, there is a lack of data on changes in the vaginal axis after pectopexy. The aim of this study was to evaluate the degree of anatomical correction achieved by laparoscopic pectopexy in patients with apical genital prolapse using magnetic resonance imaging (MRI).
Methods
Individuals who experienced pectopexy and a nulliparous control group were enrolled in this prospective observational case-control investigation. MRI scans were conducted on both the control cohort and the study group before and after the procedure. The angles formed by the pubococcygeal line and the inferior vaginal segment, the levator plate and the pubococcygeal line, as well as the inferior and superior vaginal segments, were measured and compared.
Results
The change in angle between the lower vagina and upper vagina was statistically significant, with preoperative and postoperative values of 134.91° ± 6.25° and 166.82° ± 6.15°, respectively (p = 0.0001). The angle between the lower vagina and pubococcygeal line showed a significant change, with preoperative and postoperative values of 44.64° ± 1.8° and 65.73° ± 10.19°, respectively (p = 0.0001). Postoperative angles were not similar among nulliparous patients based on the MRI findings. The postoperative Urogenital Distress Inventory scores are significantly lower than the preoperative scores (p = 0.0001).
Conclusions
The pectopexy procedure is not optimal for achieving a normal vaginal axis.
Trial registration number/date:
NCT05876975/ 26.05.2023
Costs and cost-effectiveness of the Kerala Pilot Screening Programme for Diabetic Retinopathy in the public health system
Authors: Wittenberg Raphael , Anderson Robert , Redding Stuart , Gopal Bipin , Sadanandan Rajeev , Sahasranamam Vasudeva , George Simon , Premnazir Lakshmi , Netuveli Gopalakrishnan , Srin Jyotsna , Conroy Dolores , Sivaprasad Sobha
Published: September 2023

Background/Objectives
The Government of Kerala initiated a pilot screening programme for diabetic retinopathy in 16 Family Health Centres in Thiruvananthapuram district in 2019 in collaboration with the ORNATE India project. The evaluation of this pilot included a study of its costs and cost-effectiveness to inform decisions about extending the programme throughout Kerala.
Subjects/Methods
The participants comprise all 5,307 people who were screened for diabetic retinopathy under the pilot programme for whom data could be collected.
Results
The costs of the pilot programme are estimated at INR 11.3 million ((including INR 1.9 million costs to individuals) and the benefits at 514 QALYs, slightly over one QALY per person treated. The cost per QALY was INR22,000, which is well below India’s Gross National Income per person.
Conclusions
Kerala’s 2019 pilot screening programme for diabetic retinopathy was highly cost-effective.