bluuebunny/crossref_metadata_2025 huggingface dataset:
CULTURAL HERITAGE AS A FACTOR OF SOCIO-ECONOMIC DEVELOPMENT OF THE REGION (ON THE EXAMPLE OF THE NOVGOROD REGION)
Authors:   Yaroslav-the-Wise Novgorod State University, Ugryumova M.N. , Vanyushkina O.E. ,   Yaroslav-the-Wise Novgorod State University, Sergeeva T.L. ,   Yaroslav-the-Wise Novgorod State University
Published: November 2024

In the modern world, the study of the impact of cultural heritage on the socio-economic development of the region certainly plays a significant role in the formation of cultural identity, preservation and transmission of values to future generations on the one hand, and in the devel-opment of science and tourism, creating new jobs and attracting investment in the region’s econo-my on the other hand. The purpose of the work is to reveal the concept of cultural heritage and study its impact on the socio-economic development of the region on the example of the Novgorod region. Objectives of the research consists in defining the concept of “cultural heritage”; presenting the uniqueness of Novgorod region heritage in the context of categorical typology in terms of its potential; identifying the impact of cultural heritage on the socio-economic development of the re-gion; presenting the mutual relationship in the development of such economic areas as innovation and technology, business and cultural development and identifying their importance for increasing the socio-economic value of the territory. Methodology of the research is based on the system approach and uses general scientific methods of cognition: analysis, comparison, logical reasoning, fact gathering, synthesis, as well as structural approach. The paper develops a model of cultural heritage formation; researches the cultural heritage of Novgorod region in accordance with the pre-sented model; systematizes the peculiarities of comprehensive influence of cultural heritage on the socio-economic development of the region; reveals a close relationship between the innovative de-velopment of the region, strengthening its technological positions and the preservation, restoration and study of cultural heritage on the example of the Novgorod region; describes the main factors and mechanisms through which the cultural heritage has a significant impact on the socio-economic development of the region.
GENERATIVE ARTIFICIAL INTELLIGENCE FOR BUSINESS MODELS INNOVATION:OPPORTUNITIES AND LIMITATIONS
Authors:   Institute of AppliedInformation Technologies, Stolyarov A.D. , Abramov A.V. ,   National Research Nuclear University MEPhI, Abramov V.I. ,   National Research Nuclear University MEPhI
Published: November 2024

The article examines the potential of generative artificial intelligence for business model innovation. The relevance of this material is due to the explosive growth of developments in this area due to the emergence of generative AI-based applications such as ChatGPT, Gemini, Jasper, and DALL-E. The purpose of the article is to analyze emerging opportunities in business, study emerging problems and formulate promising directions for the implementation of GAI in the presence of restrictions associated with large language models. The research methodology is based on a systematic approach used in the analysis of complex economic systems and uses general scien-tific methods of cognition: studying relevant scientific articles in publicly available sources, col-lecting facts, analysis, comparison, logical reasoning, and synthesis. It is shown that GAI can be-come a powerful tool in the process of digital transformation of companies, since it can be used to develop innovations and modernize business models of enterprises. First, generative AI serves to strengthen relationships with customers by providing instant and personalized responses to their requests, thereby improving the overall quality of service –GAI allows for intelligent processes to be carried out as quickly as possible without unnecessary costs. Possible problems of generative AI models, which can create financial, reputational, and legal risks, are considered along with the wide potential opportunities and benefits of GAI technologies for business. A framework is pre-sented to show that most of the limitations are related to the technological characteristics of generative AI, but at the same time, companies need to understand the importance of new em-ployee skills and security considerations. The scientific novelty of this work lies in proposals for the use of generative AI in business model innovation with an understanding of the limiting fac-tors associated with the features of this technology. The results obtained can be used in practice as part of the development of measures to transform the business models of companies or to im-prove the efficiency of managing the operational activities of enterprises. Although there are many challenges to using generative AI, companies need to embrace it because of its potential benefits and positive impact on business development.
THE EVOLUTION OF THE FINANCIAL SECTOR OF THE ECONOMY UNDER THE PRESSURE OF ARTIFICIAL INTELLIGENCE TECHNOLOGIES
Authors:   State University of Management, Makhalina O.M. , Makhalin V.N. ,   State University of Management
Published: November 2024

Artificial intelligence, developing actively, is gradually turning into one of the most im-portant technologies of the XXI century and turns out to be the main driver of the country’s eco-nomic development. Currently, the intensive development of artificial intelligence technologies and neurotechnologies has a powerful transformational impact on various spheres of human activity. The article provides an overview of the current trends in the development and improvement of ar-tificial intelligence and examines the process of its active penetration into the financial sector, both considering its various advantages and potential disadvantages, risks and challenges associated with its implementation. The spread of artificial intelligence in the financial sector is avalanche-like in nature and is characterized by the variety, complexity and sensitivity of the problems that arise in this case, requiring an integrated and systematic approach, considering the level of devel-opment of the proposed technological solutions of artificial intelligence. The authors examined the state of development of artificial intelligence, applied technologies that can transform financial relations, considered and evaluated the potential conditions for their development. The article also examines the conditions for the introduction and development of artificial intelligence in the fi-nancial sector, which depend on increasing the availability and quality of data, software, computing power and infrastructure, the degree of development of scientific thought and research, and the level of professional competencies. Artificial intelligence technologies are the basis for the imple-mentation and development of applied financial technologies, therefore, the article examines the prospects for the development of AI, identifies the types of trends, suggests approaches and tools and technologies for their implementation.
INNOVATIVE POTENTIAL IN THE SYSTEM OF FACTORS FOR ENSURING RUSSIA'S ECONOMIC SECURITY
Authors:   Kazan National Research Technical University named after A.N. Tupolev –KAI, Mustafina G.G. , Sergeev N.A. ,   Kazan National Research Technical University named after A.N. Tupolev –KAI
Published: November 2024

The article substantiates the thesis that the strategy of overcoming the economic crisis in-volves the development of the innovative potential of the economic system. Strengthening the posi-tions of national companies in the international market will ensure the economic security of the coun-try as a whole. It is in this digital era that the integration of innovative approaches into the country’s economy becomes not just profitable, but necessary to maintain competitiveness and relevance. The current state of the economic system, characterized by changing market demands and growing prob-lems of economic security, necessitates a paradigm shift towards digitalization. This shift opens up prospects for improving operational efficiency, unlocking the economic potential of the country’s re-gions, and forming a new format of the economic system. The purpose of the study is to determine the factors of the development of the innovative potential of the territorial development of the country in the context of increasing thelevel of economic security. The objectives of the study are to identify trends in the digital development of the economic system, to identify the possibility of developing a cybersocial system in the context of ensuring the economic security of the country. Digitalization in the economic system goes beyond the simple introduction of automation. The principles of digitalization are a holistic approach that includes data-based decision-making, artificial intelligence and the use of autonomous systems (in the ideology of Industry 4.0), which ensures the sustainability and prospects of economic security systems. In this context, the present study is aimed at determining the place and role of the development of cybersocial systems, the formation of a multi-vector space to ensure the economic security of the country’s regions and the creation of a unique economic system. The technologies of economic security management themselves are undergoing transformation, taking into account the trend towards knowledge management and cyber social systems, which is especially confirmed by the growth of companies that organize corporate universities, one of the main tasks of which is the cultivation and search for critical external factors of influence. The scientific novelty of the study is to determine the mechanism for managing the innovative potential of the region.
INVESTMENT SUPPORT FOR INNOVATION ACTIVITIES
Authors:   Belgorod State Technological University named after V.G. Shukhov, Skibin A.A. , Seroshtan M.V. ,   Belgorod State Technological University named after V.G. Shukhov
Published: November 2024

In the modern economic space, the development of the country’s innovative state is a pri-ority and strategic task for many countries, since the introduction of innovations ensures an increase in the main socio-economic indicators of the country, increases the level of competitive positions on the world stage, and accelerates the way out of the crisis of a state. In the 21st century, where there is rapid progress and technological change, innovation, like investment, is becoming an integral part of business processes and a way to ensure competitive advantage. At the same time, in order to achieve the successful implementation of innovative projects, it is important to have financial sup-port in addition to the product (service) itself. Due to the sanctions pressure, Russia’s current policy is being reformatted. The purpose of the study is to study the process of providing investment support in the context of innovation and to determine its significance. General scientific methods of cogni-tion, principles and methods of a systematic approach were used as part of the study of investment support for innovation activities in the regions. The paper considers the main importance of invest-ments as a basic economic category, approaches to considering the essence of investment activity, the features and importance of investment support in innovation, as well as the principles of inno-vation and investment support. The article analyzes the innovation and investment support of foreign countries in 2023, which is given by the example of the global innovation index. The inextricable link between innovation activity and the investment component has been proved. It is confirmed that the successful implementation of innovative and investment activities contributes to the achievement of the main priorities of innovative development of the Russian economy.
STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE FOOD SUPPLY SYSTEM
Authors:   Voronezh State University of Engineering Technologies, Qian X.
Published: November 2024

The escalation of geopolitical instability is causing a sharp increase in attention to issues of resource provision of the state and its regions. In particular, regional food supply is pivotal in shaping food security, as it is at the regional level where the foundational elements for a successful food supply system are established. In practice, regional food supply is usually viewed as a systemic process, which was used in this study as a basic scientific approach. Drawing from the findings of summarizing information from various publications, the author determined that the regional food supply system is most often and reasonably presented in the literature as a set of four subsystems, each with its own developed structure. The completed decomposition of the goals and functions of these food supply subsystems as a systemic process made it possible to more deeply understand the process under study and determine a set of assessment indicators for the functioning of the food security system in the regions of Russia. As an example, the provisions of multiple areas within the Russian Federation were assessed using 24indicators taken from the Russian Statistical Year-book, the correlation between which was analyzed using the Spearman criterion. Building upon the regression analysis findings, it was deter-mined that a rise in per capita income does not always lead to anincrease in food consumption. This is a result of alterations in consumption patterns and economic factors, including inflation and changes in food prices. Therefore, the obtained results can be used as a foundation for developing and implementing economic policies focused on the sustainable development of the food sector, as well as for refining the commonly accepted system of indicators.
Efisiensi Penggunaan CBC Calculator sebagai Alat Bantu Pengukuran Produktivitas Metode Crew Balance Chart
Authors: Aziz Muhammad Abdul , Januardi Redityo , Aliim Muhammad Syaiful
Published: November 2024

Work productivity in construction project operations is often measured using non-scientific methods due to the relatively short time required. Productivity is typically calculated based on daily production output, which is measured in the afternoon. One scientific method for measuring productivity is the Crew Balance Chart (CBC). This study aims to evaluate the efficiency that can be achieved through an Android-based application specifically designed to streamline data processing and reduce measurement time. The method used is a comparative analysis of productivity measurement duration by comparing standard CBC methods with the tools, using a tower crane operation as a case study. The findings reveal an efficiency increase of 142.1%. The use of the Android-based application reduced measurement duration by 1,11 hours, from 3,76 hours to 2,64 hours. It is important to note that the application assists only in the data processing stage, while data collection and analysis continue to follow standard CBC procedures.
The Alignment of Internal and External Audit Agencies in Administering Public Sector Audits in Indonesia
Authors: Genda Maming , Yani Ahmad , Syafiin Rezky Amalia
Published: November 2024

The management of public finance to achieve national prosperity requires the effective, efficient, and integrated work of the existing audit boards. Therefore, continuous evaluation of the alignment of internal and external audit agencies is essential to ensure reliable public financial management and prevent corruption. This study describes the performance and coordination patterns between internal and external audit agencies by detailing their synchronization patterns in administering financial audits in the Indonesian public sector. Using a normative legal research method, the study incorporates legislative and conceptual approaches. The findings reveal that the performance of both internal and external audit agencies in safeguarding public finance from fraud shows varied degrees of effectiveness. However, a comprehensive regulatory framework governing the alignment of these agencies remains absent. Furthermore, synchronization in public finance audits is pursued through a unified regulatory framework, horizontal alignment among agencies, and the establishment of clear boundaries of authority and coordination mechanisms between the internal and external audit agencies. Further research should consider the potential for consolidating various regulations of public sector audits through an omnibus law approach.
Efektivitas Pengelolaan Ruang Terbuka Hijau Wisdom Park UGM bagi Pemulihan Urban Stress di Yogyakarta
Authors: Arfani Rissa , Trimarstuti Jeki
Published: November 2024

The high population density in Yogyakarta has led to various economic issues and serves as an indicator of the rising level of depression in the Province of DIY. Urban facilities like Green Open Spaces (GOS) offer a potential means to reduce urban stress in the city. However, the GOS standards as a solution for urban stress recovery often do not align with current regulations. This study aims to assess the effectiveness of GOS at Wisdom Park UGM in mitigating urban stress among Yogyakarta residents. Using a quantitative approach, the research findings are presented deductively and descriptively. The results of the analysis highlight the potential and problems of each research aspect. The variables observed here are the goals of the visitors’ activities, the effectiveness of GOS management (including vegetation, cleanliness, design, infrastructure, and accessibility), and urban stress recovery activities within the research locus, based on a survey of 100 respondents aged 15 to 64 years old. The findings indicate that Wisdom Park UGM is fairly effective as a GOS to restore urban stress. The park’s strengths include the diversity of vegetation and fauna, convenient access via various transportation modes, affordable entry fees, and a comprehensive range of supporting activities and facilities.
Legal business geography in Russia: regional analysis and mapping using tax service open data
Authors: Syomin Pavel
Published: November 2024

This paper presents an exploratory regional analysis of legal business in Russia over the period from 2016 to 2021. The primary data source for the analysis is the Federal Tax Service (FTS) open data on small and medium-sized businesses and the number of employees of organizations. The paper proposes a reproducible methodology of working with FTS open data for regional analysis in service geography that was partially implemented in a specially designed Python command line tool. The analysis includes questions regarding the number of law firms and their employees by region, the proportion of organizations engaged in the regional legal business, the role of regions in the country’s legal business sector, the role of legal business in the regions’ economies, and the change in the number of law firms in regions over the observed period. Additionally, it briefly addresses the potential correlation between the location of district-level courts and the development of legal business. The analysis revealed that the legal business sector in Russia is highly concentrated in Moscow and St. Petersburg. These regions also occupy the top position in terms of the role of legal business within the region. However, there are other regions with relatively high levels of legal business development, which are primarily located in the European south of Russia, the Volga-Urals, and Siberia. A dichotomy emerges between regions where legal business is dominated by organizations and those where individual entrepreneurs prevail over companies. District courts are typically situated in regions with a high level of legal business development. However, the underlying mechanism of this co-location requires further investigation. The number of legal firms increased from 2016 to 2021 in the majority of regions. The year-by-year changes within the regions typically follow an inverted U-shaped pattern. This pattern is likely explained by the coronavirus (COVID-19) pandemic, which negatively impacted small and medium businesses and reversed the initial growth trend.
Perforación aórtica secundaria a cuerpo extraño. Una etiología infrecuente.
Authors: Bonomo Carolina Andrea , Gallardo Ossio Ricardo Felipe , Torrealba Malpica Carlos Luis
Published: November 2024

La perforación esofágica secundaria a cuerpos extraños es una patología infrecuente. Puede ser asintomática o asociarse a complicaciones como mediastinitis, perforación aórtica o incluso pericárdica. La fístula aortoesofágica por perforación esofágica se asocia a alta mortalidad siendo fundamental su manejo precoz.
Perspectiva quirúrgica del cuello en neoplasia endocrina múltiple tipo 1 (NEM1)
Authors: Lemus Marcenaro Montserrat Andrea , Fuchs Gonzalez Catalina , Gac Espinoza Patricio
Published: November 2024

Objetivo: Presentar la experiencia quirúrgica utilizando la titulación intraoperatoria de parathormona en cirugía índice por hiperparatiroidismo primario por neoplasia endocrina múltiple tipo 1.Materiales y métodos: Cinco pacientes portadores de neoplasia endocrina múltiple tipo 1 confirmados con estudio genético. Todos los pacientes fueron evaluados de forma multidisciplinaria. Se realizó exploración cervical bilateral y paratiroidectomía subtotal con monitorización de parathormona intraoperatoria. Se describe la presentación, hallazgos intraoperatorios y seguimiento. Resultados: Se realizó exploración cervical bilateral en todos los casos, con medición de parathormona intraoperatoria basal, a los 15 y 30 minutos. Se realizaron cambios en la conducta quirúrgica de acuerdo a los resultados en 3 casos. Todos los pacientes tuvieron evolución habitual y fueron dados de alta en buenas condiciones. Se presenta el seguimiento a 34 meses. Discusión: No se encontraron recomendaciones internacionales respecto al uso de parathormona intraoperatoria en la cirugía primaria de pacientes portadores de NEM 1. Su uso podría facilitar el tratamiento individualizado de cada paciente con el objetivo de lograr la normocalcemia prolongada.
Enfermedad Pilonidal Sacrocoxígea tratada según técnica Karydakis: Resultados quirúrgicos con más de 5 años de seguimiento
Authors: Cassana Alessandra , Villalón Cortés Ricardo
Published: November 2024

Introducción. La Enfermedad Pilonidal Sacrocoxígea (EPS) es una condición crónica inflamatoria de la piel y el tejido celular subcutáneo. Tiene alta incidencia en pacientes jóvenes masculinos. En el manejo quirúrgico existen técnicas abiertas y cerradas: la Introducción. El quiste pilonidal sacrocoxígeo es una condición crónica inflamatoria de la piel y el tejido celular subcutáneo en la dicha zona. Tiene una alta incidencia en pacientes jóvenes, predominante en sexo masculino. En el manejo quirúrgico existen múltiples técnicas: abiertas y cerradas. La operación de Karydakis es una técnica cerrada. El objetivo de este estudio es describir los resultados quirúrgicos de los pacientes operados de quiste pilonidal sacrocoxígeo con técnica quirúrgica de Karydakis, con un seguimiento de más de 5 años.Material y método. Estudio retrospectivo, observacional y transversal. Se incluyeron a todos los pacientes operados entre 2013 y 2018, con diagnóstico de quiste pilonidal, utilizando la técnica de Karydakis con un mínimo de 5 años de seguimiento. Se recolectaron características clínicas y quirúrgicas como la edad, el sexo, antecedente de absceso o quiste pilonidal previo, complicaciones y recurrencia. Asimismo, se realizó el cuestionario POSAS (Patient and Observer Scar Assesment) 2.0 adaptado transculturalmente para Chile en el 2019 para valorar cicatrices.Resultados. Se registraron 68 pacientes operados de forma ambulatoria con técnica de Karydakis entre 2013 y 2018, sin re-hospitalizaciones. 40 (58,8%) fueron de sexo masculino y la edad promedio al momento de la cirugía fue de 24,4 años (15-45 años). De ellos, el 97% (66 pacientes) tenían quistes primarios. La media de seguimiento fue de 7 años (5 – 10 años). El tamaño promedio del colgajo resecado fue de 7,3 x3,2 x 2,7 cm. El retiro de puntos fue en promedio a los 18 días postoperatorios, siendo realizado en 56 (85,3%) pacientes en el segundo control postoperatorio. La complicación postquirúrgica fue infección de sitio operatorio en 3 (4,4%) pacientes. Del total de paciente se contactó a 41 (60,3%), 1 paciente (2,4%) recidivó; 15 (36,6%) pacientes realizaron algún tipo de depilación posterior. En cuanto a la valoración subjetiva de la cicatriz postoperatoria, el promedio del puntaje total de la escala fue 20 (7 – 46).Conclusión. En nuestro grupo de pacientes, la cirugía de la enfermedad pilonidal sacrocoxígea según la técnica de Karydakis es factible de realizar ambulatoriamente, con baja morbilidad, baja recurrencia y con una buena valoración de la cicatriz, con puntaje que denota características similares a la piel normal.
EVALUASI KEBIJAKAN PENGURANGAN PENGGUNAAN KANTONG PLASTIK (STUDI KASUS DI PASAR PABEAN SURABAYA)
Authors: Ghozi Halim Ervin , Azizatun Nafi'ah Binti
Published: November 2024

The problem of plastic waste is an important issue, one of which is for the City of Surabaya, therefore the Surabaya City Government formed Perwali Surabaya No. 16 of 2022 concerning Reducing the Use of Plastic Bags. However, in its implementation, there are still many business actors who still use plastic bags, one of which is in the Pabean Market. This study aims to determine the success and provide recommendations for policies to reduce the use of plastic bags in the Pabean Market, Surabaya City. This research uses qualitative research methods, with the technique of determining snowball informants. Data collection techniques were carried out by interview, observation, and documentation methods. The research focuses on policy evaluation theory, namely input, process, outputs, and outcomes. Data analysis techniques are carried out by collecting data, condensing data, presenting data, and drawing conclusions. The results showed that the policy of reducing the use of plastic bags in the Pabean Market has not gone well because it has not fulfilled the evaluation measures, namely input, process, outputs, and outcomes. There needs to be improvements in the implementation of this policy so that obstacles can be overcome and this policy can run well in the future.
DIKOTOMI PENEGAKAN HUKUM PELANGGARAN LALULINTAS TERHADAP PENGENDARA YANG TIDAK MENGGUNAKAN HELM DI KOTA KENDARI
Authors: Wa Ode Adriani Sukma  , Sabrina Hidayat  , Kamaruddin
Published: November 2024

This research is based on the phenomenon of the people of Kendari City who think that riding on the road using a motorbike does not require wearing a helmet, especially at certain moments. This momentum such as the delivery of a corpse or even to the celebration of a democratic party, like a campaign in public areas. Some people of Kendari City only wear hats and peci (songko) at certain seasons, and some choose not to wear any head protection at all. Due to societal realities, the purpose of this research is to ascertain how law enforcement responds to drivers who don’t wear helmets in accordance with sociocultural circumstances and to understand Kendari City’s traffic law system from the perspective of Lawrence M. Friedman’s theory. The research method used is a normative-empirical method. The research results findings demonstrate that when law enforcement personnel’s roles are in conflict with the sociocultural context of Kendari City society, the application of Article 291 of the Traffic Law fails to work as best it might. At some times, including during campaigns or when delivering corpses, law enforcement officials in the traffic sector appear to find it difficult or impossible to enforce the law against drivers who don’t wear helmets. Therefore, the situation indicates that Article 291 of the Traffic Law’s traffic system doesn’t work as expected.
PERAN GCG DALAM MENGURANGI FINANCIAL DISTRESS: Dampak Penjualan dan Struktur Modal
Authors: Zalva Yunnafisah Anandya , Muhadjir Anwar  , Fani Khoirotunnisa
Published: November 2024

This study examines how sales growth and capital structure affect financial hardship and finds that sound corporate governance acts as a mitigating factor. The research population includes companies in the transportation, utilities, and infrastructure sectors listed on the IDX during the 2018–2019 period. The sample was selected using purposive sampling, with 28 companies analyzed from 2018 to 2023, resulting in a total of 168 data points. Moderated Regression Analysis (MRA) utilizing SPSS 25 was used for the analysis. The results show that while capital structure has a beneficial influence on financial hardship, sales growth has a negative effect. Furthermore, good corporate governance strengthens the relationship between sales growth, capital structure, and financial distress.
Cissus quadrangularis in Bone Healing and Oxidative Stress
Authors: Charoensup Nathirat , Sangthong Kittisak , Kongcharoen Watis
Published: November 2024

Cissus quadrangularis is a plant known for its traditional use in bone healing, has shown potential in modern pharmacological applications due to its bioactive compounds. This study investigates the therapeutic effects of Cissus quadrangularis extract on bone healing, antioxidant activity, and gastric protection. The primary objective was to evaluate its efficacy in accelerating bone regeneration, mitigating oxidative stress, and protecting the gastric mucosa from NSAID-induced damage. The methodology involved a series of in vivo experiments using rats, with treatment groups receiving the extract and control groups given a placebo. Bone healing was assessed radiographically, antioxidant activity was measured using the DPPH assay and SOD enzyme activity, and gastric protection was evaluated by counting gastric lesions. The findings revealed a 40% improvement in bone healing, a 25% increase in SOD activity, and a 60% reduction in gastric lesions in the treatment group compared to controls. These results suggest that Cissus quadrangularis has significant potential as a natural remedy for bone fractures, oxidative stress, and gastric ulcers. Future research should focus on human clinical trials, molecular mechanisms, and long-term safety to support its broader medical application.
Pharmaceutical Innovations and Stewardship Programs in Combating Antimicrobial Resistance
Authors: Merddy Ousu , Rahul Amit , Gupta Sharma , Martin James , Taylor Sarah , Wilson Matthew
Published: November 2024

This study evaluates the effectiveness of the UK’s AMR Strategy 2019-2024 in combating antimicrobial resistance (AMR), focusing on pharmaceutical innovations. By analyzing trends in human and veterinary antibiotic use alongside resistance rates, the research identifies improvements in reducing antibiotic consumption and resistance, with MRSA resistance declining from 10% in 2016 to 6% in 2023. Despite these positive trends, the research highlights ongoing challenges in the development and implementation of new antibiotics and alternative therapies. Semi-structured interviews with stakeholders, including policymakers and pharmaceutical experts, reveal barriers such as regulatory issues, slow innovation, and insufficient funding for new drug development. The study also examines case studies of pharmaceutical innovations, including β-lactamase inhibitors, bacteriophage therapies, and antimicrobial peptides, noting progress in some areas, but significant gaps in others. The research concludes that while the UK’s AMR Strategy has led to some positive outcomes, further efforts are needed to accelerate the development of novel therapies and address structural barriers in the pharmaceutical sector. Future research should focus on enhancing international collaboration, improving regulatory frameworks, and incentivizing innovation to combat AMR more effectively. Comparative analysis with other countries' strategies could also provide valuable insights for improving the UK’s response to the AMR crisis.
Qualitative-quantitative indicators to regenerate public spaces through Nature-based Solutions
Authors: Giampaoletti Marco , Amadei Fabrizio , Pani Maria Michaela
Published: November 2024

The relationship between public works and communities highlights the inherently multidimensional theme of project and evaluation linked to indicators outlined in investment plans and territorial planning. Within this context, the climate crisis necessitates intervention in the city, where public space serves as an intermediate and proximity item, dynamically recalibrating urban interactions among people, nature, and technology. The objective of this paper is to investigate public space, identifying legislative criteria in terms of sustainability and the technological-environmental solutions present in the major environmental certification protocols currently available worldwide, as well as their application in national and international case studies. This analysis allows to define an original framework of dichotomous qualitative-quantitative indicators, simultaneously examining the limitations and future developments of the research. This contribution forms part of the research outcomes undertaken, both completed and ongoing, within the framework of the 2017 PRIN Research “Tech-Start” and the research line Mission 4 – Comp. 2 funded by the NRRP.
Pengembangan E-LKPD Berbasis Video Eksperimen dan Laboratorium Virtual untuk Melatihkan Keterampilan Proses Sains Siswa pada Materi Gerak Harmonik Sederhana
Authors: Andiantosa Syah Warunadwipa , Miriam Sarah , Mahtari Saiyidah
Published: November 2024

Keterampilan proses sains (KPS) siswa pada materi gerak harmonik sederhana sering kali rendah akibat keterbatasan kegiatan praktikum dan kurangnya fasilitas laboratorium. Penelitian ini bertujuan mengembangkan E-LKPD berbasis video eksperimen dan laboratorium virtual yang dapat digunakan sebagai media pembelajaran untuk melatihkan KPS siswa secara efektif. Penelitian ini menggunakan model pengembangan ADDIE (Analyze, Design, Develop, Implement, Evaluate), dengan subjek penelitian adalah 22 siswa kelas X MIPA di SMA Negeri 12 Banjarmasin. Instrumen penelitian meliputi lembar validitas, angket kepraktisan, dan tes hasil belajar. Hasil validasi menunjukkan E-LKPD ini sangat valid pada aspek didaktik, konstruksi, dan keterampilan proses sains. Dari angket kepraktisan, E-LKPD dinilai praktis dengan rata-rata skor 70,31%, menunjukkan bahwa media ini mudah digunakan dan menarik bagi siswa. Efektivitas E-LKPD ini juga dibuktikan melalui peningkatan keterampilan proses sains siswa dengan skor N-gain sebesar 0,53 (kategori sedang). Integrasi video eksperimen dan laboratorium virtual dalam E-LKPD ini membantu siswa memahami konsep fisika dan melatih keterampilan proses sains secara mandiri. E-LKPD ini direkomendasikan sebagai alternatif pembelajaran interaktif untuk meningkatkan kompetensi sains siswa pada topik-topik yang memerlukan visualisasi konsep abstrak.
Development of E-Worksheet Based on Experimental Videos and Virtual Laboratories to Train Students' Science Process Skills in Simple Harmonic Motion
Abstract
Students' science process skills (SPS) in simple harmonic motion are often low due to limitations in laboratory practice and inadequate laboratory facilities. This study aims to develop an E-worksheet (E-LKPD) based on experimental videos and virtual laboratories that can effectively train students’ SPS in physics. The research follows the ADDIE model (Analyze, Design, Develop, Implement, Evaluate), with 22 tenth-grade students in SMA Negeri 12 Banjarmasin as research subjects. Research instruments included validation sheets, practicality questionnaires, and learning outcome tests. Validation results show that the E-LKPD is highly valid in didactic, construction, and science process skills aspects. Practicality scores averaged 70.31%, indicating that students found the E-LKPD easy to use and engaging. The effectiveness was demonstrated by an increase in SPS, with an N-gain score of 0.53 (moderate category). The integration of experimental videos and virtual laboratories in this E-LKPD aids students in understanding physics concepts and independently enhancing their science process skills. This E-LKPD is recommended as an interactive learning tool to improve students' science competence in topics requiring visualization of abstract concepts.
Manejo del choque séptico en la primera hora en pacientes adultos atendidos en la emergencia
Authors: Cardona Cerón María Gabriela
Published: November 2024

OBJETIVO: Describir el manejo del choque séptico en la primera hora en pacientes adultos atendidos en la emergencia del Hospital de Chiquimula en los años 2019 a 2023. MÉTODO: Se realizó un estudio descriptivo retrospectivo donde se obtuvo una muestra de 111 expedientes de pacientes con diagnóstico de choque séptico. RESULTADOS: El grupo etario más frecuente fue 55-64 años. El sexo femenino fue el más afectado. El 71% de los pacientes no respondió a la reanimación con fluidoterapia. El microorganismo aislado más frecuente fue Escherichia coli, siendo el urocultivo el tipo de cultivo más utilizado, sin embargo, se evidenció que el foco pulmonar fue más frecuente con 32%. La terapia antibiótica empírica más utilizada fue ceftriaxona con 37%. En 66% de los pacientes se obtuvo muestreo de lactato y se inició aminas vasoactivas en el 63% de los casos en la primera hora. CONCLUSIÓN: El manejo de choque séptico en la primera hora fue la reanimación con fluidoterapia en el 100% de los pacientes, al 98% se le inició antibiótico, al 79% se le realizó toma de muestra para cultivo microbiológico, en el 66% fue medido el lactato sérico y el 63% de pacientes se le iniciaron vasopresores en la primera hora.
Analysis of the Fundamental Prerequisites for Scientific Research
Authors: Hanjing YUE
Published: November 2024

Scientific research is a special kind of activity, aimed at understanding the world and exploring the law of things. Therefore, researchers can’t do a fruitful job without certain prerequisites: either objective or subjective. The basic objective prerequisite is that researchers must be free both physically and mentally; the subjective prerequisite is that researchers must have the spirit to doubt, the interest in research, wonderful ability to think abstractly and a knowledge structure in T shape.
A Comparative Study of Imipramine and Tolterodine for the Treatment of Children with Primary Nocturnal Enuresis
Authors: Haque Dr. Md. Nazmul , Nargis Dr. Samia , Azad Dr. Md. Abul Kalam , Nargis Dr. Samia , Islam Dr. Md. Tazrul , Mohammad Dr. Arif
Published: November 2024

Background: Nocturnal enuresis (NE), or bed-wetting, affects children aged ≥5 years after ruling out organic causes. The ICCS defines NE as intermittent urinary incontinence during sleep, categorized into monosymptomatic (MNE) and non-monosymptomatic (NMNE) forms. NE is also classified by onset: primary (no dry period) and secondary (bed-wetting after a dry period). Contributing factors include sleep disorders, stress, hereditary predisposition, and delayed bladder development. Management involves behavioral and pharmacological treatments, with desmopressin and anticholinergic drugs being common options. Aim of the study: This study aims to find out an alternate effective and safe drug for the treatment of primary nocturnal enuresis. Methods: This study was conducted at the Department of Urology(outdoor), Shahid Sk. Abu Naser Specialized Hospital, Khulna, Bangladesh from January 2020 to December 2021. After excluding 12 patient’s pre-randomizations for non-cooperation, 60 patients were split into two groups: Group A received 25mg of imipramine before bedtime, while Group B took 1mg of tolterodine tartrate twice daily evaluated efficacy over 6 months, including a 2-week behavioral modification baseline and follow-ups at 3 and 6 months. Data were analyzed using SPSS 26, employing various statistical tests with significance set at p <0.05. Result: The study involved 60 children (mean age 10.0±3.1 years, 55% male), assessing bed-wetting patterns and treatment outcomes. The majority (80%) had unsatisfactory behavioral modifications, with 35% having a family history of enuresis. Both groups (A and B) showed no significant difference in bed-wetting episodes at baseline or after 3 months of treatment. Complications were more common in Group A, including dry mouth, nausea, and insomnia. Imipramine led to a higher proportion of patients with fewer than 50 dry nights after drug withdrawal, while Tolterodine showed better results at month 3 but a higher decrease in dry ...
LA EPISTEMOLOGÍA REALISTA Y LOS MÉTODOS MIXTOS. ¿UNA VÍA PARA COMPLEMENTAR LA INVESTIGACIÓN CUALITATIVA?
Authors: Morúa Ramírez Juan , Méndez Valencia Sergio , Alba Maria del Carmen
Published: November 2024

El presente artículo es una reflexión sobre el uso de los métodos mixtos, desde una posición epistemológica realista y pragmática, para la construcción de conocimiento en el análisis de problemas complejos. Se analiza el caso de una pequeña empresa mexicana dedicada a la comercialización de aparatos eléctricos industriales, que enfrentaba un problema de continuidad en sus operaciones, lo cual ponía en riesgo su supervivencia. Las principales preguntas en la reflexión fueron: ¿Qué posición epistemológica podemos utilizar frente a problemas complejos estudiados desde un punto de vista subjetivo? Y ¿La metodología cualitativa es suficiente en estos casos para dar validez, o se requiere de una complementariedad? Se intervino en el mundo objetivo de la organización mediante la medición del desempeño y sus indicadores, y en el mundo subjetivo a través de un proceso de investigación-intervención cuyo objetivo fue ayudar a los individuos a construir un proyecto más o menos definido, en este caso, la continuidad y supervivencia de esta. Se usaron grupos de enfoque para analizar los fenómenos en el desempeño y la construcción de significados en torno a la empresa. Los principales resultados, a partir de los métodos mixtos, fueron la integración y discusión conjunta de los datos cuantitativos y cualitativos para la investigación-intervención con la finalidad de realizar inferencias producto de toda la información recabada (denominadas metainferencias), lograr un mayor entendimiento del fenómeno bajo estudio y transformar a la organización. Las bases de la epistemología realista aportan una visión complementaria al abordar lo complejo, especialmente cuando esa complejidad surge de la interpretación de los individuos. En el caso del estudio e intervención en las organizaciones, desde una perspectiva positivista, dicho estudio se limita a mejorar su desempeño como modelos ideales, sin involucrar una reflexión tanto del investigador como de los actores organizacionales
SIRKULASI PENURUNAN TEMPERATUR TERHADAP PANEL SURYA DENGAN MENGGUNAKAN ALIRAN AIR
Authors: Efriyanti Rosita , Sunarhati Marliyus
Published: November 2024

Salah satu kendala dalam penerapan pembangkit listrik tenaga surya (PLTS) adalah rendahnya efisiensi dari panel surya. Pancaran energi matahari tidak seluruhnya diubah menjadi energi dimana terdapat pula energi panas, ketidak stabilan  temperatur pada panel surya sering mengakibatkan terjadinya rugi tegangan,  maka dari itu penulis membuat metode pendingin pada panel  surya, agar temperatur pada panel bisa turun. Adapun metode penelitian yang digunakan yaitu pendingin panel surya dengan metode sirkulasi penurunan temperatur pada panel surya  dengan menggunakan aliran air pada pipa kapiler yang dipasang dibelakang permukaan panel. Pemasangan pipa kapiler sendiri berjarak 2 cm, antara  jarak yang satu dengan yang lain agar tidak terlalu rapat.Panel surya sendiri bekerja pada temperatur 250C - 300C, jika temperatur pada panel melebih istandar, maka temperatur pada panel   mealami kenaikan serta temperatur PV panel tidak stabil. Hal ini disebabkan panel terlalu panas biasanya temperatur melebihi standar yaitu 33 0C. Adapun panel surya  itu mengalami penurunan temperatur pada tengah hari sekitar pukul 11.30 – 12.30. Pada saat itu temperatur pada panel mengalami penurunan disebabkan panel terlalu panas, dalamhasilpenelitianmenunjukanhasildari panel surya yang tertinggidalamtujuhharipenelitiandalaminiirradiantertinggiadalah pada jam 12.00 PM dengan nilai irradiant 1436,9 W/m2 tercatatpada tanggal 3 Februari pada jam 11.00 PMdengan Irradiance 1284,9W/m2 dengan hasil tegangan 20,4V dan arus 0.5A dengan nilai irradian terendah terjadi pada jam 08.00 PM dengan nilai 331 W/m2 dan pukul 16.00 PM nilai irradian 109 W/m2. Adapun nilai irradian paling rendah pada saat hujan, seterusnya irradiant tidak dapat diukur.
KLASIFIKASI SENJATA TRADISIONAL JAWA TIMUR MENGGUNAKAN PENGOLAHAN CITRA DIGITAL DENGAN METODE CONVOLUTIONAL NEURAL NETWORK
Authors: Alhafis Muhammad Ilzham , Purnama Dicki Dian
Published: November 2024

Senjata tradisional Jawa Timur pada jurnal ini di klasifikasikan dengan pengolahan citra digital dengan metode Convolutional Neural Network. Dataset pada jurnal ini mempunyai gambar senjata tradisional Jawa Timur berjumlah 696 dengan dibagi 3 bagian yaitu test set, validation, dan train. Hasil percobaan menampilkan adanya performa model dengan peningkatan konsisten walaupun nilainya tidak sampai melebihi dari 0.9759 untuk validasi akurasinya. Model evaluasi dengan nilai loss rendah tetap mendapatkan akurasi 98,21%. Laporan klasifikasi hanya kelas kudi dengan performa baik sedangkan pada kelas celurit dan keris mengalami kekurangan.
RELAÇÃO ENTRE REALIZAÇÃO INSATISFATÓRIA DO PRÉ-NATAL E INCIDÊNCIA DE CASOS DE TOXOPLASMOSE GESTACIONAL E CONGÊNITA NAS REGIÕES BRASILEIRAS NOS ANOS DE 2019-2023
Authors: Both Lucas Mateus , Yong Karla Alle Marie , Lucietti Maria Luísa , Peixer Isabela Munhoz , Merlini Nathalia Martini , Tensini Gabriela Rossatto , Guarda Carisi Vitória Trentin , Dariva Esther Marcon , Santos Marina Pinto dos , Kist Bruno
Published: November 2024

A assistência pré-natal tem como principal objetivo assegurar a vida e saúde do binômio materno-infantil. Isso se dá por meio do rastreamento de quadros com potencial danoso para a mãe e o bebê, seja por meio de testes rápidos, exame físico ou exames laboratoriais, como é o caso das testagens para toxoplasmose. A toxoplasmose é uma doença causada pelo protozoário Toxoplasma gondii, que possui, dentre outras formas, as formas gestacional e congênita. Através de dados coletados dos bancos de dado SINASC e SINAN e analisados por meio da plataforma Jamovi, é possível perceber uma relação inversa entre taxas de realização de pré-natais insatisfatórios e a incidência por mil nascidos vivos, tanto de toxoplasmose gestacional e congênita. Esses achados corroboram com a hipótese de que quanto pior o pré-natal, maior o número de casos subdiagnosticados. Portanto se faz necessário maior fomento à realização de pré-natal e criação de políticas públicas que visem derrubar as barreiras que impedem a realização do mesmo.
National classifier of medical devices nс 024:2023 as a standard and methodological basis for providing the rehabilitation system with medical devices
Authors: Slabkiy Hennadiy , Sabadosh Mariana , Kartavtsev Rostislav
Published: November 2024

Aim: To present methodological approaches to the classification of medical devices in the National Classifier of Medical Devices of Ukraine NC 024: 2023 for providing the rehabilitation system with medical devices for their practical application in the development of the rehabilitation system in the country.
Materials and Methods: international and domestic legal documents on the classification of medical devices and the development of the rehabilitation system. bibliosemantic, of systemic approach and of structural-and-logical analysis.
Conclusions: methodological approaches to providing the rehabilitation system with medical devices with the use of the National Classifier of Medical Devices NC 024:2023 are presented.