bluuebunny/crossref_metadata_2025 huggingface dataset:
The works of artists of the Palekh lacquer miniature craft in the field of design of theatrical productions of the 1930s - 1970s (Palekh and Theater)
Authors: Lavrov Dmitrii Evgen'evich
Published: November 2022

The subject of the proposed research is a historical analysis of the works of the masters of the Palekh craft of the 1930s - 1970s in the field of design of theatrical productions – a little-studied phenomenon of Russian folk culture of the twentieth century. The author of the article draws the most illustrative examples, referring to the sketches created by Palekh artists for productions of the Soviet theater. Special attention in the study is paid to the largest figures of the craft who worked in the field of theatrical design: I. I. Golikov, P. D. Bazhenov, N. M. Parilov, A. A. Kotukhina. The purpose of the article is to show the importance of the creative contribution of the Palekh masters to the development of theatrical and decorative art of the Soviet era on the extensive material of numerous productions of major theaters in Moscow, Leningrad and other cities.   Using the method of comparative analysis, as well as historical-systemic and iconographic research methods, the author emphasizes the importance of knowledge about the works of Palekh artists in the field of theatrical productions for a correct understanding of the general history of Palekh craft in the twentieth century. The scientific novelty of the research consists in an attempt to analyze the topic under consideration as a single complex phenomenon. The main conclusion of the article is the thesis about the inseparable connection of Paleshan's "theatrical" works with lacquer miniature: the theatrical design works of Palekh masters appear at the same time with their experiments with lacquer miniature; the largest Palekh miniaturists worked with theaters; during the entire Soviet period, Paleshan's experience in theatrical and decorative art was in demand as much as and their lacquer miniature.
Tinjauan Yuridis Perlindungan Konsumen Terhadap Masyarakat Yang Melakukan Fintech Peer-To-Peer Lending Atau Layanan Pinjam Meminjam Uang Berbasis Teknologi Informasi (Lpmubti) Dalam Sebuah Aplikasi Pinjaman Online (Julo) (Studi Penelitian : Otoritas Jasa
Authors: M Rahman Adinata  , Recca Ayu Hapsari
Published: November 2022

Perkembangan layanan internet semakin meningkat sejalan dengan pesatnya pertumbuhan teknologi informasi,inovasi produk dan perkembangan teknologi merupakan bagian integral dari evolusi industri perbankan untuk menaikan kualitas layanan, supaya efisien agar mendapatkan kemudahan yang lebih cepat dan baik. Permasalahan bagaimana perlindungan konsumen bagi pengguna layanan FinTech (peer-to-peer lending) dalam perspektif UU Perlindungan Konsumen Indonesia dan upaya penyelesaian sengketa pada layanan pinjaman peer-to-peer dari aplikasi JULO. Metode penelitian menggunakan pendekatan yuridis normatif dan empiris. Peer-to-peer lending merupakan model kerjasama antara satu pihak dengan pihak lainnya. Pinjaman bersama menghubungkan antara rentenir yang memberikan uang tunai langsung kepada peminjam dengan struktur yang diberikan melalui organisasi yang tepat. Dalam Pedoman OJK tentang Penjaminan Pembeli Dalam Wilayah Administrasi Moneter diatur bahwa setiap LJK wajib memiliki satuan kerja dan tambahan kerja, hanya sebagai sistem pendampingan dan pengaduan pembeli. - Penyelesaian perdebatan melalui pemikiran atau melalui eksekutif hukum. Penyelesaian pertanyaan melalui musyawarah dibantu melalui perantara Badan Penyelesaian Perdebatan Pilihan (LAPS). Perlindungan Hukum FinTech (pinjaman bersama) di Indonesia diusulkan oleh Otoritas Administrasi Moneter. Asuransi pembeli diatur dalam Undang-Undang Jaminan Pembeli Nomor 8 Tahun 1999, dan Otoritas Administrasi Moneter telah memberikan pedoman nomor POJK: 1/POJK. 07/2013 tentang Asuransi Nasabah Di Bidang Administrasi Moneter.
THE CONCEPT OF PERSONAL IDENTITY IN MODERN SOCIO-PHILOSOPHI-CAL DISCOURSE: THEORETICAL AND METHODOLOGICAL ASPECT
Authors:   Siberian Federal University, Krasnoyasrk, Russia, Yakovleva L. S. , Kudashov V. I. ,   Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyasrk, Russia
Published: November 2022

Relevance: The article is devoted to the socio-philosophical comprehension of the personal identity problem in the Internet. The situation of our time, characterized by “fluidity,” the variability of self-images, “masks”, has a resemblance to virtual space, which allows the individual to “try on” various social roles. The problem of personal identity requires a socio-philosophical understanding in the modern world. Purpose: to reflect the modern vision of sociologists and philosophers of the concept of personal identity, to identify the main characteristics of personal identity on the Internet. Methods of research: The theoretical and methodological basis of the study is the structural and constructivist approach. This approach is based on the conception that identities are the construct of the personality itself, they can be transformed depending on the individual’s choice, while the structure of society is determined by the identities system. The main results: A modern individual can be described as an individual of mass information consumption. The study of modern socio-philosophical works of the concept of personal identity allows us to determine the following characteristics: variability associated with social context; procedural nature; structure planning; reflexivity; categorization; selection. Scientific novelty of the study lies in the author’s position, according to which the key characteristics of personal identity include: variability related to the social context; procedural nature; construction; categorization; choice. Directions for future research: in further research, the problem of personal identity in the conditions of Internet communication will be considered by us in the context of the dichotomies “private-public”, “I-Other”, which will make it possible to understand how personal identity is formed and transformed in the modern Internet.
IFRS 16 «RENT»: THE MAIN CAUSES OF OCCURANCE
Authors:   Perm State National Research University, Perm, Russia, Kadochnikova A. V.
Published: November 2022

Renting has become increasingly important in recent years. Often, international business representatives, and sometimes entire industries, opt for leasing, refusing to purchase large and expensive assets. Such industries include retail companies, airlines, healthcare, telecommunications, transport, logistics, etc. These business representatives, due to the specifics of their activities, prefer leasing the largest assets to acquiring them. IFRS 16 Leases, published on January 13, 2016, became mandatory for the first time when reporting for 2019 by entities. This standard is a recommendation for the reflection in the financial statements of organizations of information about objects that have been transferred or received on lease. The methodology for reflecting leases in financial statements has often become the subject of discussion in professional circles. Dissatisfaction with the provisions of the earlier IAS 17 “Leases” on the part of business representatives, analysts, scientists and other users provoked the development and subsequent adoption of IFRS 16 “Leases”. The article explores the main prerequisites and reasons for the development of new provisions, which later became the basis for the current international standard for accounting for leases. The purpose of the work is to identify the main negative consequences of the application of IAS 17 “Lease”, the main reasons for the development of the provisions of IFRS 16 “Lease”, which is in force today. An analysis of the reasons for the emergence of this standard and foreign experience in its use will help to assess the consequences of applying its Russian counterpart FSBU 25/2018 “Lease Accounting”: to analyze the possibility of solving the main issues that arise for external and internal users of financial information, and to determine the impact of the new domestic standard lease accounting has an impact on the reliability and comparability of financial statements, the financial condition and performance of Russian companies, which is of scientific value. In the course of the study, such general scientific methods of cognition as comparative analysis, generalization of theoretical and factual material were used. It was found that the application of IAS 17 “Lease” by companies had a negative impact on the accuracy and transparency of reporting compiled by companies, which provoked dissatisfaction on the part of investors, analysts and other users. The author gives the main reasons for changing the previously existing lease accounting model and further development of IFRS 16 “Leases”.
RESULTS OF THE STUDY OF THE RELATIONSHIP BETWEEN THE NUMBER OF ROLLING STOCK UNITS OF FREIGHT ROAD TRANSPORT AND GROSS REGIONAL PRODUCTS
Authors:   Orenburg State University, Orenburg, Russia, Lyubimov I. I. , Yakunin N. N. ,   Orenburg State University, Orenburg, Russia, Yakunina N. V. ,   Orenburg State University, Orenburg, Russia
Published: November 2022

Road transport is an important branch of the national economy. This is due to many of its advantages compared to other modes of transport, primarily high mobility and the ability to deliver goods “to the doorstep”. The activities of road freight transport are carried out within two main groups. The first group is transportation carried out under contracts between business entities, the second — to meet their own technological needs of busi¬ness entities. Information on the first group contains official statistical reporting, information on the second group is missing. This situation leads to the impossibility of an objective assessment of the impact of road transport on the socio-economic development of regions, causing inadequate reactions in the systems of road transport, for example, in the areas of regulation of the structure of road transport and personnel training. This is the reason for the relevance of the work. The aim of the work is to establish the relationship between the number of rolling stock of freight road transport and indicators of gross regional products (GRP), taking into account parts of gross regional products by industry. As the approach used, the hypothesis is used that: the socio-economic development of the regions is impos¬sible without an efficiently functioning freight road transport; The existing official information support of the state and activity of road freight transport does not allow an objective assessment of its impact on the socio-economic development of the regions. The methodological apparatus of the study is based on the application of the principles of system analysis, methods of mathematical statistics, in particular, correlation and regression analysis. The paper uses the official statistical information of Rosstat on road freight transportation, the number of trucks in the regions, gross regional products and parts of gross regional products by industry. The scientific novelty of the study lies in the identified relationship between the number of trucks and gross regional products of the constituent entities of the Russian Federation, as well as parts of gross regional products by industry, characterized by the establishment of general and particular relationships between economic and technical indicators. The novelty of the study is a toolkit for managing road freight transport. The practical significance of the study lies in the creation of tools for managing the operation of road transport to regulate the structure of freight vehicles in accordance with the objectives of the development of the regions. Directions for further research are to apply the above methodology to passenger road transport for the devel¬opment of a management system for regional transport systems.
Endoscopically observed outer membrane of chronic subdural hematoma after endovascular embolization of middle meningeal artery
Authors: Nomura Sadahiro , Haji Kohei , Fujiyama Yuichi , Nishimoto Takuma , Oka Fumiaki , Ishihara Hideyuki
Published: November 2022

Background:

Embolization of the middle meningeal artery (MMA) has been established for chronic subdural hematoma (CSDH). Neuroendoscopic observation of the outer membrane of the hematoma was carried out after embolization. The treatment mechanism of embolization is discussed, focusing on the vasculature and inflammation of the membrane.

Methods:

Four patients with recurrent CSDH were included in this study. The MMA was embolized using Embosphere® particles in three patients. The outer membrane was observed with normal and narrow band images (NBIs).

Results:

The net-like vessels were not obstructed in the whole area of the outer membrane, but in a patchy fashion of embolized areas surrounded by nonembolized areas. In two patients, the nonembolized areas showed a hemorrhagic inflammatory red color. Histopathological examination confirmed hypertrophic dura with leukocyte infiltration. Dilated dural arteries and proliferated sinusoid arteries were located in the deep and superficial border cell layers. These arteries were visualized as green and brown on NBI, respectively. In the embolized area, the red membrane turned pink, indicating ischemia and subsiding inflammatory hyperemia. In the third patient, the outer membrane was white in both the nonembolized and embolized areas in endoscopic view, and the net-like vessels were sparse in both endoscopy and histology, indicating a scar inflammatory phase. The membrane transition was not observed in the patient that did not undergo embolization.

Conclusion:

Endoscopic observation revealed that embolization of the MMA blocked both the dural and sinusoidal arteries. Ischemic transformation causing the suppression of inflammation of the outer membrane is a suggested mechanism of MMA embolization.
Atypical slow-flow paramedian AVM with venous varix
Authors: Ismail Mustafa , Al-Ageely Teeba A. , Talib Sura H. , Hadi Rania Thamir , Al-Taie Rania H. , Aktham Awfa A. , Alrawi Mohammed A. , Salih Hayder R. , Al-Jehani Hosam , Hoz Samer S.
Published: November 2022

Background:

Cerebral arteriovenous malformations (CAVMs) are either clinically silent or symptomatic. The most common presentation in more than half of all CAVMs presenting patients is hemorrhage which is accompanied by long-standing neurological morbidity and mortality. This report presents a case of an atypical large, slow-flow paramedian AVM with a dilated venous varix managed with surgery. The impact of the intraoperative findings on the diagnosis and the operative technique will be discussed.

Case Description:

In otherwise, healthy 26-year-old male complained of repeated episodes of generalized seizures and loss of consciousness. Brain magnetic resonance imaging (MRI) revealed a right parietal paramedian arteriovenous malformation (AVM) with signs of an old hemorrhagic cavity beneath it. Digital subtraction angiography demonstrated a slow-filling AVM with dilated venous varix drains into the superior sagittal sinus. However, the exact point of drainage cannot be appreciated. The filling of the AVM occurred precisely with the beginning of the venous phase. Intraoperatively, we noticed a whitish spherical mass, thick hemosiderin tissue, and a large cavity below the nidus; then, a complication-free complete microsurgical resection of this high-grade AVM was performed. Postoperatively, the patient suffered two attacks of seizures in the first few hours after the surgery, for which he received antiepileptics. MRI was clear during follow-up, and the patient was seizure-free and neurologically intact.

Conclusion:

Parietal convexity AVMs are challenging lesions to tackle. However, the chronicity and the slow-filling of the AVM, in this case, can render the surgical pathway more direct and accessible.
The Challenges of Afghan Migrants in Türkiye
Authors: Pouya Jafar
Published: November 2022

Migration of an individual or a group occurs as a result of aggravating socio-economical, politic or security-based conditions. Migration isn’t simply a pickup-and-go process, but it comes with some challenges and opportunities for both migrants and relevant countries. Ongoing war and conflicts for five decades in Afghanistan have forced Afghans to emigrate at various times. But this unplanned migration movements have seemed to create much more challenges than opportunities because of the large number of Afghan population settling down illegally in the host countries, including Türkiye. The daunting economic consequences of the global Covid-19 pandemy in Türkiye as well as increasing massive surge of Afghan asylum seekers have brought about social disturbance and several problems in some local cities, which forced the government to have taken special precautions about outlawed asylum seekers in order to calm down the public reaction and to ensure the social stability. Furthermore, Afghans, who constitute the largest part of the total population of migrant community in Türkiye, have faced some risks and challenges both on the way of, and after, the migration -such as, security, deportation and so on. Therefore, this article aims at making some new contribution about migration studies by throwing light on the painful circumstances of the displaced Afghans, especially after the Taliban took over the power in the country.
Estimating the Number of Molecules in Molecular Junctions Merely Based on the Low Bias Tunneling Conductance at Variable Temperature
Authors: Baldea Ioan
Published: November 2022

Temperature ($T$) dependent conductance $G = G(T)$ data measured in molecular junctions are routinely taken as evidence for a two-step hopping mechanism. The present paper emphasizes that this is not necessarily the case. A curve of $\ln G$ versus $1/T$ decreasing almost linearly (Arrhenius-like regime) and eventually switching to a nearly horizontal plateau (Sommerfeld regime), or possessing a slope gradually decreasing with increasing $1/T$ is fully compatible with a single-step tunneling mechanism. The results for the dependence of $G$ on $T$ presented include both analytical exact and accurate approximate formulas and numerical simulations. To be specific, we analyze in detail data available for molecular junctions based on ferrocene (Fc). As a particularly important finding, we show how the present analytic formulas for $G=G(T)$ can be utilized to compute the ratio $f = A_{\mbox{\small eff}} / A_n$ between the effective and nominal areas of large area Fc-based junctions with an EGaIn top electrode. Our estimate $f\approx 0.6 \times 10^{-4}$ is comparable with previously reported values for related large area molecular junctions.
Stereoselective Boron-Masking of polyBorylated-Alkenes: An Access to Stereodefined polyMetalloid Alkenes
Authors: Eghbarieh Nadim , Hanania Nicole , Masarwa Ahmad
Published: November 2022

Polyborylated-alkenes are valuable reagents in modern organic synthesis, providing access to a wide array of transformations, including the construction of multiple C–C and C–heteroatom bonds. However, because they contain similar boryl groups, many times their transformation faces the main challenge in controlling the chemo-, regio- and stereoselectivity. One way to overcome these limitations is by installing different boron groups that can provide an opportunity to tune their reactivity toward better chemo-, regio- and stereoselectivity. However, the preparation of polyborylated-alkenes containing different boryl groups has been rare. Herein we report concise, highly site-selective, and stereoselective boron-masking strategies of polyborylated alkenes. This was achieved by designed stereoselective "trifluorination" and “MIDA-ation” reactions of readily available starting polyborylated alkenes. Additionally, the trifluoroborylated-alkenes underwent a stereospecific interconversion to Bdan-alkenes. These transition-metal free reactions provide a general and efficient method for the conversion of polyborylated alkenes to access 1,1-di-, 1,2-di-, 1,1,2-tris-(borylated) alkenes containing BF3Cs, Bdan, and BMIDA, a family of compounds that currently lack efficient synthetic access. Moreover, tetraborylethene underwent the metal-free “MIDA-ation” reaction to provide the mono BMIDA tetraboryl alkene selectively. Given its simplicity and versatility, these novel stereoselective boron-masking approaches hold great promise for organoboron synthesis and will result in more novel transformations.
UnCorrupt SMILES: a novel approach to de novo design
Authors: Schoenmaker Linde , Béquignon Olivier , Jespers Willem , van Westen Gerard
Published: November 2022

Generative deep learning models have emerged as a powerful approach for de novo drug design, as they aid researchers in finding new molecules with desired properties. Despite continuous improvements in the field, a subset of the outputs that sequence-based de novo generators produce cannot be progressed due to errors. Here, we propose to fix these invalid outputs post hoc. In similar tasks, transformer models from the field of natural language processing have been shown to be very effective. Therefore, here this type of model was trained to translate invalid Simplified Molecular-Input Line-Entry System (SMILES) into valid representations. The performance of this SMILES corrector was evaluated on four representative methods of de novo generation: a recurrent neural network (RNN), a target-directed RNN, a generative adversarial network (GAN), and a variational autoencoder (VAE). This study has found that the percentage of invalid outputs from these specific generative models ranges between 4 and 89 %, with different models having different error type distributions. Post hoc correction of SMILES increases model validity, with the SMILES corrector fixing 35 to 80 % of invalid model outputs. While, corrector models trained with one error per input sequence alter 60 to 90 % of invalid inputs, a higher performance was obtained for transformer models trained with multiple errors per input. In this case, the best model was able to correct 60 to 95 % of invalid generator outputs. Further analysis showed that these fixed molecules are comparable to the correct molecules from the de novo generators with regard to novelty and similarity. Additionally, the SMILES corrector can also be used to expand the amount of interesting new molecules within the targeted chemical space. Introducing different errors into existing molecules yields novel analogs with a uniqueness of 39 % and a novelty of approximately 20 %. The results of this research demonstrate that SMILES correction is a viable post hoc extension and can enhance the search for better drug candidates.
Protein and RNA ADP-ribosylation detection is influenced by sample preparation and reagents used
Authors: Weixler Lisa , Ikenga Nonso Josephat , Voorneveld Jim , Aydin Gülcan , Bolte Timo MHR , Momoh Jeffrey , Bütepage Mareike , Golzmann Alexandra , Lüscher Bernhard , Filippov Dmitri V , Žaja Roko , Feijs Karla LH
Published: November 2022

The modification of substrates with ADP-ribose (ADPr) is important in, for example, antiviral immunity and cancer. Recently, several reagents were developed to detect ADP-ribosylation; however, it is unknown whether they recognise ADPr, specific amino acid–ADPr linkages, or ADPr with the surrounding protein backbone. We first optimised methods to prepare extracts containing ADPr–proteins and observe that depending on the amino acid modified, the modification is heatlabile. We tested the reactivity of available reagents with diverse ADP-ribosylated protein and RNA substrates and observed that not all reagents are equally suited for all substrates. Next, we determined cross-reactivity with adenylylated RNA, AMPylated proteins, and metabolites, including NADH, which are detected by some reagents. Lastly, we analysed ADP-ribosylation using confocal microscopy, where depending on the fixation method, either mitochondrion, nucleus, or nucleolus is stained. This study allows future work dissecting the function of ADP-ribosylation in cells, both on protein and on RNA substrates, as we optimised sample preparation methods and have defined the reagents suitable for specific methods and substrates.
Lipid saturation induces degradation of squalene epoxidase for sterol homeostasis and cell survival
Authors: Huang Leng-Jie , Chen Rey-Huei
Published: November 2022

A fluid membrane containing a mix of unsaturated and saturated lipids is essential for life. However, it is unclear how lipid saturation might affect lipid homeostasis, membrane-associated proteins, and membrane organelles. Here, we generate temperature-sensitive mutants of the sole fatty acid desaturase geneOLE1in the budding yeastSaccharomyces cerevisiae. Using these mutants, we show that lipid saturation triggers the endoplasmic reticulum–associated degradation (ERAD) of squalene epoxidase Erg1, a rate-limiting enzyme in sterol biosynthesis, via the E3 ligase Doa10-Ubc7 complex. We identify the P469L mutation that abolishes the lipid saturation–induced ERAD of Erg1. Overexpressed WT or stable Erg1 mutants all mislocalize into foci in theole1mutant, whereas the stable Erg1 causes aberrant ER and severely compromises the growth ofole1, which are recapitulated bydoa10deletion. The toxicity of the stable Erg1 anddoa10deletion is due to the accumulation of lanosterol and misfolded proteins inole1. Our study identifies Erg1 as a novel lipid saturation–regulated ERAD target, manifesting a close link between lipid homeostasis and proteostasis that maintains sterol homeostasis under the lipid saturation condition for cell survival.
A Home-Like Urbanity: designing urban architecture through spatial intimacies of home in Aotearoa New Zealand
Authors:   , Meyer-Knight Harriet
Published: November 2022

In Aotearoa, home is a very deeply held concept. It colours our understanding of architecture, causes our cities to stretch across the landscape, and is perhaps why our cities, when viewed from afar, are curiously un-urban. This paper reports on design research into spatial intimacies of home/ kāinga and how they are embedded into Aotearoa NZ urban architecture.

The research attempts to intensify this curious condition through a series of projects. The projects delve into our home-like understanding of architecture, focussing on spatial intimacy, and progress from the scale of the body to domestic scale, to exploring home-like intimacies at the scale of the city. The research is supported by work on atmosphere (Zumthor, Bohme), new materialisms (Bruno, Bennett, Ahmed) spatial imagination (Van Schaik), and embodiment (Peri-Bader). The work begins with a spatial installation, testing interwoven intimacies of body, material and threshold. The intention is to promote a shared agency between the occupant, space and the architectural object. The results of this first stage inform the design of a series of architectural interventions, situated in an Aotearoa city, interrogating this ‘agency’ with an urban frame of reference. In this, the smaller public spaces are used as vehicle to distil and intensify spatial intimacy at a larger scale. The research culminates in the design of a large scale urban public building. This project takes the results from the previous scales of design research and scales up in size and urban function. A public building is designed, situated in an Aotearoa city, which intensifies home-like spatial intimacy, enriching urban architecture with personal, emotive atmospheres of home.

The contribution of this research is in three areas: it adds to understandings of the spatial intimacy of home, how home-like intimacy can project to and enrich urban architecture, and ultimately, it provides insights into the deep entanglement of home and the Aotearoa New Zealand city.
Antibiotic resistance surveillance of Klebsiella pneumoniae complex is affected by refined MALDI-TOF identification, Swiss data, 2017 to 2022
Authors: Voellmy Irene Katharina , Lang Claudia , Gasser Michael , Kronenberg Andreas ,   on behalf of the Swiss Centre for Antibiotic Resistance (ANRESIS)
Published: November 2022

Background

Modern laboratory methods such as next generation sequencing and MALDI-TOF allow identification of novel bacterial species. This can affect surveillance of infections and antimicrobial resistance. From 2017, increasing numbers of medical microbiology laboratories in Switzerland differentiated Klebsiella variicola from Klebsiella pneumoniae complex using updated MALDI-TOF databases, whereas many laboratories still report them as K. pneumoniae or K. pneumoniae complex.

Aim

Our study explored whether separate reporting of K. variicola and the Klebsiella pneumoniae complex affected the ANRESIS surveillance database.

Methods

We analysed antibiotic susceptibility rates and specimen types of K. variicola and non-K. variicola-K. pneumoniae complex isolates reported by Swiss medical laboratories to the ANRESIS database (Swiss Centre for Antibiotic Resistance) from January 2017 to June 2022.

Results

Analysis of Swiss antimicrobial resistance data revealed increased susceptibility rates of K. variicola compared with species of the K. pneumoniae complex other than K. variicola in all six antibiotic classes tested. This can lead to underestimated resistance rates of K. pneumoniae complex in laboratories that do not specifically identify K. variicola. Furthermore, K. variicola strains were significantly more often reported from blood and primarily sterile specimens than isolates of the K. pneumoniae complex other than K. variicola, indicating increased invasiveness of K. variicola.

Conclusion

Our data suggest that refined differentiation of the K. pneumoniae complex can improve our understanding of its taxonomy, susceptibility, epidemiology and clinical significance, thus providing more precise information to clinicians and epidemiologists.
CNN Tabanlı Derin Öğrenme Yaklaşımı ile Kanser Görüntülerinin Sınıflandırılması
Authors: ÇETİNER Halit
Published: November 2022

İnsanların güneşin zararlı ışınlarının sebebiyet verdiği etkiler sonucunda halk arasında melanoma (mel), dermafibroma (df), ve vascular (vasc), bening keratosis (bkl), melanocytic nevi (nv), basal cell carcinoma (bcc), actinic keratosis (akiec) olarak bilinen türler sıklıkla görülmektedir. Biyomedikal cihazlar kullanılarak elde edilen cilt görüntüleri üzerinde yapılan derin öğrenme analizleri ile girdi olarak verilen cilt görüntüsünün kanser ise hangi cilt kanseri olduğu belirlenebilmektedir. Bu maksatla cilt alanında çalışan sağlık uzmanlarının iş yoğunluğunu düşürecek, hızlı tanı ve sınıflandırma yapabilecek CNN tabanlı bir derin öğrenme modeli önerilmiştir. Swish ve ReLU aktivasyon fonksiyonunun avantajlarından faydalanılarak geliştirilen CNN modeli akiec, bcc, bkl, df, nv, vasc, mel cilt kanseri sınıf türlerinde 0.99%, 0.99%, 0.96%, 0.99%, 0.92%, 0.99%, 0.95% F1 score değerlerini elde etmiştir
PHYSICAL LIMITATIONS OF COMPUTER TECHNOLOGY PROGRESS
Authors:   Russian State University for the Humanities, Podorozhnyi Andrey M.
Published: November 2022

The paper analyzes the existing element base of computer technology. It is shown that the physical foundations of the element base have not changed over the past 70 years: the absolute majority of computing equipment is created on the basis of silicon semiconductor transistors. There was an improvement in technology, a reduction of transistors to nanoscale, which led to an increase in computing power by many orders of magnitude. Further improvement of the silicon semiconductor technology comes into conflict with fundamental physical laws: the need for heat removal, the impossibility of overcoming the speed of light, ineliminable current leakage due to the tunneling effect caused by the quantum mechanical uncertainty ratio. Despite marketing statements, so far no one has managed to create transistors smaller than 25 nm. Moore’s law stopped working, the development of the element base slowed down. In this regard, the issue of creating a fundamentally new element base of computers is acute. The most promising areas are the creation of graphenebased transistors, as well as quantum computers. However, those areas cannot yet serve as a full-fledged replacement for existing technologies.
EMPIRICAL STUDY OF THE POWER OF THE KOLMOGOROV–SMIRNOV STATISTICAL TEST IN PROBLEMS OF TESTING HYPOTHESES ABOUT THE DISTRIBUTION LAW
Authors:   Russian State University for the Humanities, Sinitsyn Vyacheslav Yu. , Stupakova Ekaterina S. ,   Russian State University for the Humanities
Published: November 2022

Statistical tests that use A.N. Kolmogorov one-sample statistics and N.V. Smirnov two-sample statistics have been widely used for solving applied problems for almost a hundred years. Those criteria are present in many textbooks and implemented in computer software for data analysis. The purpose of the work is to empirically estimate the power of the Kolmogorov–Smirnov criterion on a set of test problems to check hypotheses about the distribution law, as well as to investigate the properties of estimates of the power of the criterion for various types of resampling. To obtain various estimates of the power of the Kolmogorov–Smirnov criterion in solving test problems, the classical bootstrap, nonparametric bootstrap, parametric bootstrap, bootstrap with a random term, and resampling without returns were used. Based on the results of multiple solution of test problems, medians of p-values, medians of estimates of the power of the Kolmogorov–Smirnov criterion were calculated, and medians of biases of estimates on test problems and medians of all pairwise dif﻿ferences of various estimates of the power of the criterion were found. The distribution laws for the considered Kolmogorov–Smirnov power estimates, for the biases of the power estimates, and for all pairwise differences of the power estimates were investigated. For test problems where real data were considered, calculating power estimates without resampling is impossible, but unbiased power estimates can be predicted as the half-sum of two other power estimates, one obtained with a nonparametric bootstrap and the other obtained with resampling without returns. Methods for restructuring sample data and software for estimating the power of a statistical test developed within the study are universal and can be used for analyzing the properties of power estimates of other one-sample statistical tests, as well as for developing the classical methodology for checking statistical hypotheses.
PENGARUH PROFITABILITAS, FIRM SIZE DAN AKTIVITAS PERUSAHAAN TERHADAP PENGUNGKAPAN SUSTAINABILITY REPORT
Authors: Damayanty Prisila , Wahab Dodi , Safitri Nurmelia
Published: November 2022

The purpose of this study is to look at the effect of profitability, firm size, and company activities on disclosure of sustainability reports. The measurement index used as a reference for the sustainability report in this study is the Global Reporting Initiative (GRI) G4. The population in this study is non-financial sector companies listed on the Indonesia Stock Exchange in 2016-2019. The sample companies in this study were selected based on a purposive sampling method with several criteria to obtain 10 sample companies. After the data are collected, data analysis is done using multiple linear regression analysis with the help of the SPSS program. Based on the results of the analysis, it shows that the profitability variable has a negative effect on the disclosure of sustainability report. And company activities variable has a positive effect on the disclosure of sustainability report. While the firm size variable did not affect the disclosure of sustainability report.

Keywords: Profitability, Firm Size, Company Activities, Sustainability Report.
PERANCANGAN PERBAIKAN PROGRAM KOMUNIKASI PEMASARAN RIHIJAB MENGGUNAKAN METODE BENCHMARKING DAN TOOL ANALYTICAL HIERARCHY PROCESS
Authors: Devi Nabilla Mutia , Amani Husni , Sagita Boby Hera
Published: November 2022

Rihijab is one of the Micro, Small and Medium Enterprises (MSMEs) located in Central Java and is engaged in the fashion sector. Rihijab focuses its business on producing and selling hijabs for women with an age range of 16 to 40 years. Rihijab has a problem regarding unstable sales, this is supported by the acquisition of sales data from November 2020 to December 2021 which fluctuates and tends to not meet the sales targets determined every month. Rihijab has implemented seven of the eight marketing communication mixes which have not been implemented optimally. This resulted in problems regarding the lack of public awareness of Rihijab which can be proven by the low number of Instagram followers when compared to its competitors. This final project research aims to design a marketing communication improvement using the benchmarking method and the analytical hierarchy process (AHP) tool. Benchmarking method will be used to determine the best marketing communication that has been implemented by competitors so that it can be used as a reference in improving Rihijab's marketing communication program. The analytical hierarchy process (AHP) tool will be used to find out which competitors are selected as Rihijab's benchmark partners. Based on the results of data processing obtained 14 attributes that are used as a reference in designing an integrated system for improving marketing communication programs at Rihijab.

Keywords: Marketing Communication Program, Benchmarking Method, Tool analytical hierarchy process
PENGARUH BUDAYA ORGANISASI DAN DESAIN PEKERJAAN TERHADAP PRODUKTIVITAS KERJA KARYAWAN PERKEBUNAN KELAPA SAWIT BAHILANG TEBING TINGGI
Authors: Rusmewahni Rusmewahni
Published: November 2022

The purpose of this study was to determine how much influence Organizational Culture and Job Design have on employee productivity. After analyzing the Multiple Linear Regression test: Y = 13,445+ 0,258X1 + 0,314X2 indicates that the magnitude of the role of Organizational Culture and Design variables is positively related to employee productivity. Then the coefficient of determination test (R2) shows the Adjusted R Square result of 0.182 or 18.2%, this shows that the Organizational Culture variable (X1) and the Job Design variable (X2) explain the employee productivity variable of 18.2%. Furthermore, for the F (simultaneous) test, Fcount (4.681) > Ftable (3.32) and a significance value of 0.005
PENGARUH KOMPETENSI DAN KNOWLEDGE SHARING TERHADAP OCB DENGAN MEDIASI KOMITMEN ORGANISASIONAL (STUDI PADA PEGAWAI BPSDMD PROVINSI JAWA TENGAH
Authors: Astuti Rohmy Irma , Suhana Suhana
Published: November 2022

Perilaku pegawai diharapkan tidak hanya berkaitan dengan tugas-tugas yang telah ditetapkan namun lebih dari itu juga perilaku yang tidak ditetapkan dalam job description organisasi yang dikenal sebagai Organizational Citizenship Behavior. Penelitian ini bertujuan menguji kompetensi, knowledge sharing dan komitmen organisasional sebagai faktor yang berpengaruh terhadap organizational citizenship behavior. Peran komitmen organisasional juga diuji dalam penelitian ini. Populasi merupakan pegawai di lingkungan BPSDMD Provinsi Jawa Tengah yang berjumlah 267 orang. Dengan purposive sampling didapat 174 responden. Analisis data menggunakan regresi. Pengujian mediasi menggunakan uji sobel. Hasilnya, pengujian regresi mendapatkan p value untuk hubungan kompetensi, knowledge sharing terhadap komitmen organisasional lebih kecil dari 0,05 (p=0,000). Nilai signifikansi untuk hubungan kompetensi, knowledge sharing dan komitmen organisasional terhadap OCB kurang dari 0,05 (p=0,000). Uji sobel mendapatkan signifikansi kurang dari 0,05. Kesimpulan, kompetensi dan knowledge sharing berpengaruh positif dan signifikan terhadap komitmenn organisasional. Kompetensi, knowledge sharing ddan komitmen organisasional berpengaruh positif dan signifikan terhadap OCB. Hubungan kompetensi dan knowledge sharing terhadap OCB dimediasi oleh komitmen organisasional.

Kata kunci: organizational citizenship behavior, kompetensi, knowledge sharing, komitmen organisasional
STRATEGI PENGEMBANGAN PRODUK BAWANG MERAH CRISPY MENGGUNAKAN TEKNIK ANALISIS SWOT
Authors: Hajar Neli , Maghfiroh Laelatul , Fitralisma Gian , Iskandar Khalid
Published: November 2022

Study aims to make a decision on the development strategy that will be applied to the crispy shallot product of PT Sinergi Brebes Inovatif. Through strategic planning the analysis of internal factors and external factors. The method used in this study is a qualitative descriptive method. Process of collecting data by means of interviews and questionnaires, the respondents in this study were all employees of PT SBI totaling 19 people. Data analysis in this study used SWOT analysis. Results of this study show that PT SBI's crispy shallot products are in cell IV in the IE matrix, which means it grows and develops. Strategy obtained through QSPM analysis is to maintain product quality despite the high market demand, highlight products that can be consumed by anyone and at any time so that they can be remembered by consumers as friendly and safe products, increase the retail market outside the Brebes Regency area by utilizing events organized by the government with the impression of local products that Go National, add packaging that is smaller than the actual size to overcome decrease in consumer purchasing power in event of social conditions such as the Covid-19 pandemic.
Seguimiento de trayectoria de un robot manipulador móvil de 8 grados de libertad: KUKA youBot.
Authors: Pérez-Fuentevilla Jorge Gustavo , Morales-Díaz América Berenice , Rodríguez-Ángeles Alejandro
Published: November 2022

En este trabajo se propone un controlador no lineal basado en un esquema de control por par calculado que resuelve el problema de seguimiento de trayectoria a nivel de posición y velocidad para un robot manipulador móvil (RMM) de 8 grados de libertad considerando una base móvil diferencial de tipo (2,0) que satisface la restricción no holonómica. Se presenta un análisis de estabilidad usando el método de Lyapunov; se logra demostrar estabilidad semiglobal, uniforme y últimamente acotada (UUB). Se obtienen resultados experimentales usando el modelo KUKA youBot. Los resultados presentan una buena convergencia y desempeño del control aún teniendo incertidumbres paramétricas.
Dispositivo de bajo costo para la enseñanza-aprendizaje de la robótica
Authors: Hernandez-Oliva Noemi , Alcántara-Sánchez Crhistian Rodrigo , Islas-Ortiz Mihael Shamed , Alejandre-Flores Marisol , Pedroza-Villalba Martin
Published: November 2022

En este trabajo se presenta la implementación de un dispositivo, integrado por un modelo de robot a escala obtenido mediante impresión 3D de tipo FDM (Fuse Desposition Modeling) tomando como base un robot ABB IRB 460 industrial y una tarjeta programable Arduino UNO R3, el cual puede ser utilizado para la enseñanza de la robótica a nivel superior. Para ello se obtuvo el modelo cinemático del robot a escala, el cual se uso como dispositivo de prueba cuando no es posible tener acceso a un robot real. Por ese motivo se programó en Matlab el cálculo de la cinemática directa propia del robot empleando el método de Denavit-Hartenberg, misma que puede ser programada en la tarjeta Arduino conectado al robot. Una vez concluidas las pruebas, se demostró que los resultados obtenidos son similares. Además, es posible realizar dichas validaciones a la par, a partir de la modificación de los parámetros del robot en cada uno de los respectivos programas, permitiendo a los alumnos la interacción con un modelo a escala y su manipulación cuando no es posible tener el robot real. También permite incluir otro tipo de programas conforme avance su curso y de igual forma ser validados con este mismo esquema desarrollado.
Navegación autónoma en interiores basada en localización visual
Authors: Rico-Mendoza Hugo Ivan , Reyna-Rodríguez Misael , Morales-Díaz América , Ordaz-Hernández Keny , Treesatayapun Chidentree
Published: November 2022

En este artículo se desarrolla una ley de control para navegación autónoma en interiores basada en la detección visual de marcadores de referencia. Técnicas de estimación de pose externas como la localización por GPS o sensores RGB-D en techos son complicados de implementar en entornos cerrados donde puede haber obstrucci´on de vista o señal, como en almacenes, por lo que la estimación de pose local con sensores a bordo presenta una solución más viable. La implementaci´on de cámaras web de alta definición supone una solución más económica que el uso de sensores de alta calidad como sensores láser tipo Lidar. En la ley de control diseñada se considera a un marcador visual ArUco en su campo de visión, como un marco referencial inercial local. Con base en los errores medidos por odometr´ıa es posible ejecutar la tarea de regulación hacia éste marcador.
Control de velocidad para servomecanismos libre de modelo
Authors: Cortez-Dena Edgar , Contreras-Mendoza Héctor , Mastranzo-Pérez Maribel , Ranírez-Muñoz Edgar , Guerrero-Castellanos José F.
Published: November 2022

En este trabajo se propone un control no lineal con rechazo activo de perturbaciones como controlador de velocidad para servomotores y servomecanismos. En la actual propuesta, tanto la perturbación total, como la ganancia de control no son conocidas, lo cual lo hace muy atractivo en aplicaciones industriales. El control se evaluó experimentalmente usando la plataforma experimental “servo-system”. Se realiza un comparativo de los resultados obtenidos con la técnica de control propuesta frente a un controlador proporcional integral y se discuten los resultados.
Asistencia robotizada adaptable del miembro superior basado en respuesta biomecánica y fisiológica del humano
Authors: Valdés-Rincón Elizabeth , Domínguez-Ramírez Omar Arturo , Lechuca-Gutiérrez Luis Rey
Published: November 2022

Dentro de los procesos de rehabilitación por medio de asistencia robotizada se estudian diferentes aplicaciones y múltiples tipos de control, permitiendo la repetición de los procesos. Los resultados de estos estudios no consideran las condiciones del humano dentro del lazo de control, por lo cual se plantea el caracterizar el esfuerzo del usuario por medio de las señales mioélectricas del miembro superior obtenidas por el brazalete Myo, siendo el modificador de un indicador dentro de la consigna de control PD+G. Con lo cual, se tomó muestras de las señales mioelectricas mientras se realizó una tarea con el robot, procesadas con un filtro Kernel Gaussiano, para la caracterización del esfuerzo por medio del método de polinomios anidados. Los resultados obtenidos permiten establecer una región dentro del espacio de trabajo del robot donde el esfuerzo del paciente es el mínimo, de esta forma incorporar condiciones biomecánicas dentro del proceso de guiado háptico.
Management in Shaping the Self Efficacy Santri of Islamic Boarding School Panggung Tulungagung
Authors: Safi'i Asrof
Published: November 2022

belum ada
ANALYSIS OF SURFACE GILLNET FISHING GEAR AT BAGAN SIAPI-API WATERS, INDONESIA USING EAFM INDICATORS
Authors: Dharmawan Rahmad , Suherman Agus , Mudzakir Abdul Kohar
Published: November 2022

The fisheries management based on the Ecosystem Approach to Fisheries Management (EAFM) can be implemented to optimize the potential of fisheries resources. The purpose of this research is to apply EAFM indicators for analyzing surface gillnet fishing gear in Bagan Siapi-api waters, especially fish resources, fishing methods, habitats, and ecosystems. The evaluation of fishery management status was carried out using multi-criteria analysis (MCA) through the development of the composite index of each EAFM indicator. The results showed that the surface gillnet fishing gear was dominant with 1,645 tons of fish caught in 2019 by fishermen in Bagan Siapi-Api Waters. The composition of the catches was sukain fish (Eleutheronema tetradactylum), flounder fish (Pleuronectiformes), and tornfish (Bovichthyidae). Based on the analysis of the EAFM indicators, the value of the domain of fish resources, habitats, and ecosystems, as well as fishing methods has a value between 2 and 2.5. This indicated that the status of ecosystem-based area management in the waters of Bagan Siapi-api is in the medium-good category.

Keywords: Bagan Siapi-api, EAFM, Fisheries Sustainability, Gill Net