bluuebunny/crossref_metadata_2025 huggingface dataset:
STUDI HIDROGEOLOGI TERHADAP KAPASITAS DEBIT AIR TANAH MENGGUNAKAN METODE PUMPING TEST PADA DAERAH BIROMARU KABUPATEN SIGI
Authors: Hamad Harly
Published: September 2022

Groundwater is a natural resource that can be renewed naturally, but the time of renewal is very relative. In meeting the needs of groundwater in the community, it is necessary to strive for groundwater produced can be periodically available. The purpose of this study was to aquifer condition and determine the capacity for groundwater discharge in the Biromaru area, precisely in Lolu Village. The data collection method used is the pumping test long-term test method and the analytical method used is the Neuman curve-fitting method and Theis recovery method. Based on the test and aquifer test results of lithological correlation, value of transmissivity 180,001 m2/day, storativity 3,7 x 10-3, specific yield 2,56 x 10-2, hydraulic conductivity 14,572, permeability 16,488. The potential for groundwater discharge in the study area is between 226,067 cm3/day. The maximum available discharge is 146.88 m3/day, while the groundwater discharge that has been exploited from production wells in the research area is ≥363,461.28 m3 which has been used for ±52 weeks so that the pumping discharge does not exceed the potential groundwater discharge.
KONTROL GEOLOGI DAN POTENSI KROMIT PADA P.T. X DAERAH WOSU, KAB. MOROWALI, PROV. SULAWESI TENGAH
Authors: Puspita Riska
Published: September 2022

Kromit sangat dibutuhkan dalam industri konstruksi sebagai agen anti-korosi dan pemberi kesan mengkilap untuk pembuatan stainless steels, campuran baja, baja cor, dan besi cor. PT.X yang berlokasi di daerah Wosu memiliki potensi mineral kromit yang perlu diteliti lebih lanjut. Penelitian ini bertujuan untuk mengetahui kontrol geologi pembentukan mineral kromit, karakteristik dan potensi mineral kromit di daerah penelitian. Metode yang digunakan yaitu metode pemetaan geologi permukaan dan bawah permukaan. Pemetaan geologi permukaan meliputi aspek geomorfologi, stratigrafi, dan struktur geologi. Pemetaan bawah permukaan menggunakan metode pemboran. Mineral kromit pada daerah penelitian dikontrol oleh aspek geologi yaitu geomorfologi berupa pelapukan, erosi dan sedimentasi dimana pada daerah-daerah yang relatif datar sebagai tempat terakumulasinya material hasil dari proses geomorfologi tersebut. Karakteristik mineral kromit pada daerah penelitian berwarna hitam dan mempunyai bentuk mineral rounded. Hasil perhitungan cadangan ditemukan jumlah cadangan sebesar 14.294 ton, jumlah cadangan dibagi menjadi dua grade yaitu grade 1 (100% Cr2O3) sebesar 4.084 Ton dan grade 2 (40%Cr2O3) sebesar 10.210 ton.
ANALISI KETERSEDIAAN AIR UNTUK DAERAH IRIGASI KAWATUNA
Authors: Sari Riska Kartika
Published: September 2022

Daerah Irigasi Kawatuna merupakan Daerah Irigasi yang memanfaatkan potensi air dari Sungai Kawatuna dengan luas areal fungsional 28 Ha. Daerah Irigasi Kawatuna melayani kebutuhan air irigasi untuk Kecamatan Kawatuna dan Lasoani. Studi ini bertujuan untuk mengetahui debit kebutuhan Daerah Irigasi Kawatuna terhadap ketersediaan air dari Sungai Kawatuna. Metode Penman Modifikasi digunakan untuk menghitung besarnya evapotranspirasi (Eto). Sedangkan Debit Andalan dihitung berdasarkan data curah hujan dari stasiun Mutiara Sis Al-Jufri Palu dengan menggunakan Metode NRECA. Dari hasil analisis diperoleh ketersediaan air Daerah Irigasi Kawatuna untuk periode 2006-2015 sebesar -0,009 m3/det, sedangkan kebutuhan air sebesar 0,070 m3/det. Dari evaluasi tersebut, dapat disimpulkan bahwa ketersediaan air pada Daerah Irigasi Kawatuna tidak cukup untuk memenuhi kebutuhan air pada lahan fungsional dan mengairi areal irigasi secara terus-menerus
ANALISIS FAKTOR YANG MEMPENGARUHI KEBERHASILAN TENDER ELETRONIK BERDASARKAN PERSEPSI KONTRAKTOR DI PALU
Authors: Mangitung Donny Marga
Published: September 2022

Tender eletrronik (e-tendering) dapat meningkatkan transparansi dan akuntabilitas; meningkatkan akses pasar dan persaingan yang sehat; meningkatkan efisiensi proses pengadaan serta  dapatmengurangi waktu proses, biaya transportasi dan dokumen tender yang diusulkan. Namun dalam pelaksanaannya masih terdapat beberapa kendala, seperti tingkat layanan keandalan dan kinerja infrastruktur teknologi Informasi dan komunkasi (TIK) serta pengetahuan para pihak tentang prosedur pelaksaaan tender eletronik. Untuk mengidentifikasi kendala tersebut, kuesioner disebar ke kontraktor di Palu dan dikembalikan 35 responden, dimana kuesioner tersebut menggunakan dua puluh lima faktor yang mempengaruhi keberhasilan pelaksanaan e-tendering berdasarkan skala Likert 1-6. Data dianalisis dengan teknik Analisis Faktor dan hasilnya menunjukkan bahwa faktor-faktor tersebut dikelompokkan menjadi 6 faktor penentu yang terdiri dari 1. Keandalan sistem layanan situs web e-tendering; 2. Manajemen Pengukuran Kinerja dan pengembangan layanan e-tendering; 3. Manajemen Keamanan dan keberlangsungan sistem layanan e-tendering; 4. Keandalan Manajemen Layanan Infrastruktur TIK; 5. Ketersediaan Tenaga Ahli dan Standarisasi organisasi layanan TIK; dan 6. Pengetahuan regulasi dan pengetahuan layanan e-tendering.
Analisis Tinggi Air Banjir Pada Sungai Sombe Berdasarkan Debit Banjir Metode Rasional
Authors: Saparuddin Saparuddin
Published: September 2022

Masalah banjir menarik perhatian setelah mempengaruhi kehidupan manusia dan menimbulkan bencana/kerugian bagi masyarakat di sekitar lingkungan sungai tersebut. Terjadinya banjir/peluapan dapat dibedakan oleh beberapa macam, yaitu debit terlalu besar atau kapasitas pengaliran sungai berkurang. Hal ini dapat terjadi oleh gejala alamiah atau akibat kekurang hati-hatian kegiatan manusia dalam melakukan pembinaan/pengelolaan sungai untuk berbagai kepentingan. Tujuan penelitian ini yaitu untuk mengetahui debit banjir dan juga tinggi banjir menggunaan metode rasional. Metode ini digunakan untuk menghitung debit banjit rencana pada sungai Sombe yang berada di daerah Sigi, Sulawesi Tengah. Data- data yang diperlukan untuk menghitung debit banjir rencana pada sungai ini yaitu data curah hujan, data tata guna lahan di sekitar sungai dan juga data kemiringan sungai. Selain mencari debit banjir pada sungai Sombe, tinggi banjir juga dianalisis, yaitu dengan cara mengumpulkan data penampang sungai Sombe dengan cara pengukuran langsung di lapangan selama 1 hari. Berdasarkan hasil pengamatan, data debit banjir rencana yang didapatkan pada sungai Sombe dengan menggunakan metode rasional yaitu 16,84 m3/dt, 17,44 m3/dt, 18,99 m3/dt, 20,00 m3/dt dan 20,95 m3/dt masing-masing untuk periode ulang 5,10,25,50 dan 100 tahun, sedangkan data tinggi banjir yaitu setinggi 2,12 meter.
JENIS DAN LUAS KERUSAKAN RUAS JALAN PAGIMANA-BIAK BERDASARKAN METODE PAVEMENT CONDITION INDEX
Authors: Lutfie Mukhtar , Andi M. Andi , Samaduri L
Published: September 2022

Ruas jalan Pagimana – Biak merupakan jalan provinsi yang menghubungkan ke tempat-tempat pariwisata, industri dan sebagai sarana angkutan pedesaan dan angkutan perkotaan, maka diperlukan perawatan dan perbaikan agar dapat melayani lalu lintas sesuai fungsinya. Studi terhadap kondisi jalan diperlukan sebelum dilakukan perawatan dan perbaikan. Metode yang digunakan meliputi pengumpulan dan pengolahan data kerusakan jalan secara kuantitatif.  Penelitian ini bertujuan untuk mengetahui tingkat kerusakan pada ruas jalan Pagimana-Bunta dengan mengkaji jenis dan luas kerusakan berdasarkan metode PCI. Pelaksanaan penelitian ini meliputi menilai kondisi perkerasan secara visual dengan metode Pavement Condition Index (PCI) dengan membagi ruas jalan Pagimana – Biak sepanjang 1.400 meter, lebar perkerasan jalan 7 m, lebar bahu jalan 1,5 m dan kelandaian jalan 2 %. menjadi 14 sampel unit. Hasil penelitian ini mengetahui jenis kerusakan yang terjadi pada jalan yaitu retak acak, lubang, dan pelepasan butiran.  Jenis kerusakan terbesar adalah retak acak dan jalan berlubang, kerusakan yang terjadi di ruas jalan Pagimana - Biak seluas 1522,17 m2 atau 15,5323% terhadap luas total yang diteliti. Perkerasan mampu mendukung beban lalu lintas, jika dilihat rata-rata nilai PCI 81,7143 dengan rating sangat baik (very good), maka kerusakan perkerasan tersebut termasuk dalam kerusakan fungsional. Perbaikan kerusakan dilakukan dengan jenis, lokasi dan tingkat kerusakannya
The Role Of Student Satisfaction In The Roots Of Determining Word Of Mouth (Wom)
Authors: Santoso Aprih , Widowati Sri Yuni , Auliya Zakky Fahma
Published: September 2022

Abstract This study aims to determine the effect of service quality and Word Of Mouth (WOM) on student satisfaction at the University of Semarang as an Intervening Variable. The independent variable in this study is the quality of service and the dependent variable is Word of Mouth (WOM) while the Intervening Variable is student satisfaction at the University of Semarang. The research was conducted by taking a sample of 129 students of the University of Semarang. The research method uses accident sampling. The technical analysis in this study uses Path analysis. The result shows that service quality and satisfaction directly effect the Word Of Mouth (WOM) of the University of Semarang students. Service quality) has a direct influence on student satisfaction at the University of Semarang and satisfaction is able to moderate the effect of service quality on the Word Of Mouth (WOM) of of the University of Semarang students
Clinical characteristics of pediatric allogeneic hematopoietic stem cell transplantation-associated thrombotic microangiopathy (TA-TMA): A retrospective single-center analysis
Authors: Luo Linlin , xiong hao , Chen Zhi , Yang Li , Sun Ming , Lu Wenjie , Tao Fang , Wang Zhuo , Li Jianxin , Li Zuofeng , Tang Sujie
Published: September 2022

Transplantation-associated thrombotic microangiopathy (TA-TMA) is one of
the most serious complications of allogeneic hematopoietic stem cell
transplantation (allo-HSCT) and is characterized by microvascular
hemolytic anemia and thrombocytopenia. To further our understanding of
the clinical characteristics of TA-TMA in pediatric patients, we
retrospectively analyzed 20 pediatric patients with TA-TMA from August
1, 2016 to December 31, 2021 in our center. During this period, 209
patients received allo-HSCT in our department, 20 (9.6%) of whom
developed TA-TMA. TA-TMA was diagnosed at a median of 94 (7–289) days
post-HSCT. Eleven (55%) patients had early TA-TMA within 100 days
post-HSCT, while the other 9 (45%) patients had TA-TMA thereafter. The
most common symptom of TA-TMA was ecchymosis (55%), while the main
signs were refractory hypertension (90%) and multi-cavity effusion
(35%). Five (25%) patients had central nervous system symptoms
(convulsions and lethargy). Median follow-up time was 8 (1–26) months.
All 20 patients had progressive thrombocytopenia, with 16 patients
receiving transfusion of platelets that was ineffective. Ruptured red
blood cells were visible in only two patients with peripheral blood
smears. Cyclosporine A or Tacrolimus (CNI) dose was reduced once TA-TMA
was diagnosed. Nineteen cases were treated with low-molecular-weight
heparin, 17 patients received plasma exchange, and 12 patients were
treated with rituximab. TA-TMA-related mortality percentage in this
study was 45% (9/20). Of the 11 patients who were effectively treated
initially, 4 died of sepsis and acute respiratory failure. In
conclusion, platelet decline and/or ineffective transfusion post-HSCT
should be considered an early indicator of TA-TMA in pediatric patients.
TA-TMA in pediatric patients may occur without evidence of peripheral
blood schistocytes. Aggressive treatment is required once diagnosis is
confirmed, but the long-term prognosis is poor.
Household transmission of SARS-CoV-2 during the Omicron wave in Shanghai, China：a case-ascertained study
Authors: Wei Zhongqiu , Ma Wenjie , Wang Zhonglin , Li Jingjing , Fu Xiaomin , Chang Hailing , Qiu Yue , Tian He , Zhu Yanfeng , Xia Aimei , Wu Qianhui , Liu Gongbao , Zhai Xiaowen , Zhang Xiaobo , Wang Yan , Zeng Mei
Published: September 2022

Since late 2021, the highly transmissible SARS-CoV-2 Omicron variant has
driven a new surge of infections across the world. We used a
case-ascertained study to determine the features of household
transmission of SARS-CoV-2 Omicron variant in Shanghai, China. We
collected detailed information on 323 pediatric cases and their 951
household members, all received consecutively intensive RT-PCR testing.
We estimated the transmission parameters. Both secondary infection
attack rates (SARI) and secondary clinical attack rates (SARC) among
adult household contacts were computed, through which the transmission
heterogeneities in infectivity and susceptibility were characterized and
the vaccine effectiveness were estimated. The mean incubation period and
serial interval of Omicron variant were estimated to be 4.6±2.1 days and
3.9±3.7 days. The overall SARI and SARC among adult household contacts
were 77.11% (95% confidence interval [CI]: 73.58%-80.63%) and
67.03% (63.09%-70.98%). We found higher household susceptibility in
females, while infectivity was not significantly different in primary
cases by age, sex, vaccination status and clinical severity. Full
vaccination and booster vaccination of inactivated vaccines were 14.8%
(5.8%-22.9%) and 18.9% (9.0%-27.7%) effective against Omicron
infection and 21.5% (10.4%-31.2%) and 24.3% (12.3%-34.7%)
effective against symptomatic disease. Overall, we found high household
transmission during the Omicron wave in Shanghai due to asymptomatic and
pre-symptomatic transmission in the context of city-wide lockdown,
indicating the importance of early detection and timely isolation of
SARS-CoV-2 infections and quarantine of close contacts. Marginal
effectiveness of inactivated vaccines against Omicron infection poses
great challenge for prevention and control of the SARS-CoV-2 Omicron
variant.
Atypical presentation of syphilis: rapidly progressive glomerulonephritis
Authors: Usmael Semir , Gebremedhin Tesfay
Published: September 2022

Introduction: Rapidly progressive glomerulonephritis is a very rare and
atypical form of renal syphilis. Case presentation: 50 year old lady
presented facial swelling, hematuria, and elevated creatinine. Both RPR
and TPHA was reactive. Treatment with weekly benzathine penicillin
resulted in dramatic response. Conclusion: consider syphilis as
reversible cause of RPGN.
Kant’s moral theory as a guide in philanthropy
Authors: Radovanovic Bojana
Published: September 2022

This paper focuses on Kant?s moral theory and how it can guide our actions in
philanthropy. Philanthropy is usually defined as a voluntary action aimed at
relieving suffering and improving the quality of lives of others. It has
been argued that, within the framework of Kant?s theory, it is our duty to
be beneficent, sacrificing a part of our welfare for others. The duty of
beneficence is a wide one. Interpreters of Kant disagree on what the wide
duty of beneficence requires. While a few argue that it only requires that
we provide help sometimes, others hold that the duty of beneficence should
be seen as more demanding, particularly in cases of emergency when help is
urgently required. We are morally obliged to promote the happiness of
others, but the duty of beneficence does not tell us whose happiness and how
much of our resources to give. Other than emergency cases, in fulfilling the
duty of beneficence, we can prioritize the ends of those near and dear to us
who concern us more. Moreover, on condition that we are not indifferent to
others, it is morally permissible to prioritize our ends. Finally, the paper
argues that it is not always straightforward what kind of action is required
in helping someone in need, and that beneficence in Kantian terms is not
limited to the philanthropic sector.
Bachelard en vacances: The subject of surrationalism and its functional value
Authors: Ristic Marko
Published: September 2022

This paper deals with the problem of the subject in Bachelard?s concept of
surrationalism. Focusing on the epistemological character of surrational
creativity, the issue of the subject is approached through the analysis of
the relationship between subjectivity and objectivity in the surrational
act. Comparing the character of novelty in surrealism and surrationalism,
the paper introduces Bachelard?s distinction between formal and material
imagination, with the latter further discussed through the prepositions
?against? [contre] and ?in? [dans]. Bachelard?s theory of the internal
dialectic - the theory of subdivision of the subject - is analyzed through
his concept of reverie. The last chapter deals with the dialectic between
the apodictic and the assertoric subject, aiming to reconsider the idea of
interiority and repose.
The learning curve of the direct anterior approach is 100 cases: an analysis based on 15,875 total hip arthroplasties in the Dutch Arthroplasty Register
Authors: Peters Rinne M , Ten Have Bas L E F , Rykov Kyrill , Van Steenbergen Liza , Putter Hein , Rutgers Marijn , Vos Stan , Van Steijnen Bob , Poolman Rudolf W , Vehmeijer Stephan B W , Zijlstra Wierd P
Published: September 2022

Background and purpose: In the last decade, the direct anterior approach (DAA) for total hip arthroplasty (THA) has become more popular in the Netherlands. Therefore, we investigated the learning curve and survival rate of the DAA in primary THA, using data from the Dutch Arthroplasty Register (LROI).Patients and methods: We identified all patients who received a primary THA using the DAA in several high-volume centers in the Netherlands between 2007 and 2019 (n = 15,903). Procedures were ordered per surgeon, using date of operation. Using the procedure number, operations were divided into 6 groups based on the number of previous procedures per surgeon (first 25, 26–50, 51–100, 101–150, 151–200, > 200). Data from different surgeons in different hospitals was pooled together. Revision rates were calculated using a multilevel time-to-event analysis.Results: Patients operated on in group 1–25 (hazard ratio [HR] 1.6; 95% CI 1.1–2.4) and 26–50 (HR 1.6; CI 1.1–2.5) had a higher risk for revision compared with patients operated on in group > 200 THAs. Between 50 and 100 procedures the revision risk was increased (HR 1.3; CI 0.9–1.9), albeit not statistically significant. From 100 procedures onwards the HR for revision was respectively 1.0 (CI 0.6–1.6) and 0.8 (CI 0.5–1.4) for patients in operation groups 101–150 and 151–200. Main reasons for revision were loosening of the stem (29%), periprosthetic infection (19%), and dislocation (16%).Interpretation: We found a 64% increased risk of revision for patients undergoing THA using the DAA for the first 50 cases per surgeon. Between 50 and 100 cases, this risk was 30% increased, but not statistically significant. From 100 cases onwards, a steady state had been reached in revision rate. The learning curve for DAA therefore is around 100 cases.
Retrospective Cohort Study on Asian Patients with Hidradenitis Suppurativa: Factors Associated with the Efficacy of Antibiotic Treatment
Authors: Jang Yun Kyung , Moon Sujin , Shin Jung U , Kim Dong Hyun , Lee Hee Jung
Published: September 2022

Abstract is missing (Short communication)
Perceptive Hierarchy of Facial Skin Lesions: An Eye-tracking Study
Authors: Jankowski Marek , Goroncy Agnieszka
Published: September 2022

Equal importance is given to every skin lesion in treatment guidelines and severity grading systems for facial lesions. Face recognition studies suggest differentially perceived areas of the human face. The aims of this study were to quantify the visual attention given to facial skin lesions and to explore their hierarchy. Eye movements were tracked in 118 participants who viewed 135 faces with facial skin lesions. The main effect of the image was significant (F[9, 1053]=15.631, p < 0.001, η2=0.118), which implied a difference in the total visual attention between images depicting skin lesions in different aesthetic units. Lesions in the frontal area received the highest area- specific attention, while lesions in the right parotid area had the smallest effect. Using objective computational clustering, 2 very distinct zones of visual attention were identified: the ocular, nasal, perioral, and frontal areas attracted high visual scrutiny and the remaining areas attracted little attention. However, the presence of skin lesions in the high-attention region resulted in a decrease in total visual attention to the face. The main effect of the aesthetic unit was significant (F[15, 1755]=202.178, p < 0.001, η2=0.633). More than 63% of attention-drawing potential of facial skin lesions depends on their anatomical location, which should be considered in disease severity grading and treatment planning.
Asymmetrical Periflexural Exanthem Associated with SARS-CoV-2 Infection in a Paediatric Patient
Authors: Valencia-Herrera Adriana , Ganoza-Granados Luciana , Camargo-Sánchez Karen , Chirino-Barceló Yazmín A. , Toledo-Bahena Mirna
Published: September 2022

Abstract is missing (Short communication)
Novel Approaches in Green Extraction for Natural Medicines
Authors: S Jani
Published: September 2022

Green extraction is based on discovery and design of extraction process which will reduce unit operation, reduce energy consumption, reduce time consumption, reduce organic solvent use, alternate solvent with water or agro-solvent and ensure safe and high-quality extract. In this study the conventional extraction methods and various green extraction methods were compared. Both these studies on extraction process were done in the past, in this review those studies were compared. From this we can know that which method is suitable for extraction which will not harmful for the environment, promote the health of patient, produce by-product or co-product instead of waste.
Bioavailability and Functionality of Conjugated Fatty Acids in Foods
Authors: J Mancini-Filho
Published: September 2022

Dietary conjugated fatty acids are associated with heart disease, obesity, diabetes, cancer and others; in addition, many functions of cell membranes are dependent on lipid composition and lipids ingested through the diet can modify this composition and their biochemical activity. Due to the discoveries of their chemical and physiological properties, there is a growing interest in conjugated fatty acids as well as in the properties of their isomers. Conjugated fatty acids (CFAs) are the general term to describe the positional and geometric isomers of polyunsaturated fatty acids with conjugated double bonds, which are separated by a single carbon-carbon bond rather than being separated by a methylene group (CH2). Theoretically, several isomers of conjugated fatty acids are possible, with multiple combinations of numerical, positional and geometric configurations of the conjugation of double bonds, which may present as conjugated linoleic and α-linolenic acids and may have different functionalities in the body.
Emerging Approaches and Perception of Toxicity Assessment in Nanomaterials
Authors: S Lakshmana Prabu
Published: September 2022

In the 21st century, nanotechnology, an interdisciplinary research has become an innovative field and made a new revolution in science and technology. Its unique properties has led an extensive research interest among the researchers and utilized in various fields including biomedical applications. Increased use of nanomaterials in health sciences and medicine aroused a global concern on the biological response, effectiveness, and toxicity of these materials. Therefore, it has become imperative in studying the toxicity of nanomaterial (Nanotoxicology) in therapeutic applications. The main aim of nanotoxicological studies is to determine the toxic/hazardous effects of nanomaterials on humans and to the environment. The toxicity of the nanomaterials depends on various physicochemical properties such as size, shape, surface area, surface chemistry, concentration and several others parameters. Nanomaterials have shown higher toxicity particularly in inhalation studies, hence stringent regulations are made for nanotechnology products to ensure the safety of the products. There are few approaches to overcome these toxicities and improve its therapeutic efficacy and safety. Hence development of nanotechnology should occur on par with risk assessment to identify and subsequently avoid possible dangers in the near future. This article highlights on the different nanomaterials, their unique properties and frameworks for assessing the toxicity of nanomaterials.
Exploring Efficacy of Bauhinia Variegata as Medicinal Herb in Combating Different Clinical Conditions: A Systematic Review
Authors: S Kumar
Published: September 2022

Nowadays, the use of herbal therapy has reached its maximum hike. Lesser adverse events make this approach more prominent among the population. Bauhinia variegata, which is one of the medicinal plants employed in various indications like antibacterial, and various cancers, is practiced in the Indian traditional health system of Ayurveda. This plant natively belongs to the tropical Indian subcontinent. The phytoconstituents like glucokinins, inorganic ions sulphur compounds, coumarins, phenolic compounds (polyphenols, flavonoids), steroids, amines, peptides, terpenes, glycopeptides, and polysaccharides are associated with hypoglycemic effects. Glucokinins possess functional similarity with insulin. Its literature showed its expected indications in wide range i.e. cancer, diabetes, oxidative stress, depression. Therapeutic activities of this plant are based on chemical constituents present in it. Despite using the raw plant, using the extract is more prominent and suitable for treatment. The method of extraction of chemical constituents is very important. The extraction should be done without altering the therapeutic constituents. This review gives a thorough insight into the plant's chemical constituents, extraction methodologies, and different clinical conditions in which different parts of this plant are used. As a conclusion, this plant has shown great potential due to its plethora of chemical constituents which could also be explored in other indications with same mechanism of action is required.
MicroRNA in Prognosis, Diagnosis and Therapy of Cancer
Authors: Vasdev Kavita
Published: September 2022

MicroRNAs have been demonstrated to regulate fundamental cellular processes and, their alteration has been correlated with a variety of human cancers. Due to this, great enthusiasm has been shown in the use of miRNAs as a target in cancer therapy. Although we have made major advances in the understanding of cancer biology and pathogenesis as well as in the development of new targeted therapies, the progress in developing tests for early diagnosis and screening has been inadequate. As a result, most cancers are diagnosed in advanced stages, leading to low survival rate. Intense research today is focused on seeking specific molecular changes that are able to identify patients with early cancer or precursor lesions, for better treatment of patients. Emerging evidence suggests that inhibition of overexpressed oncogenic miRNAs or substitution of tumor suppressive miRNAs could become a novel treatment strategy in cancer therapy.
The Mycelial Mire-Mucormycosis
Authors: Bajaj Anubha
Published: September 2022

Mucormycosis is an infrequent, angio-invasive, fatal fungal infection incriminating immunocompromised individuals. Mucormycosis commonly arises due to infection with rapidly progressive, pauci-septate moulds or fungal species such as Rhizopus, Mucor, Lichtheimia (Absidia) or Entomophthorales. Mucormycosis is a significant, secondary fungal infection associated with SARS-CoV-2 infection wherein pulmonary mucormycosis and rhinocerebral mucormycosis are commonly engendered. Especially, a triad of mucormycosis, diabetes mellitus and prolonged corticosteroid therapy is exemplified in subjects with COVID-19. Elevated plasma glucose, reduced pH, free iron and ketones along with decreased white blood cell phagocytic activity amplifies propagation of mucor. Mucormycosis commences with inhalation or ingestion of environmental spores which are subsequently phagocytosed within polymorphonuclear cells. Mucormycosis appears within the nasal cavity, paranasal sinuses, orbit, central nervous system (CNS), pulmonary parenchyma, gastrointestinal tract (GIT), cutaneous surfaces, jaw bones, joints, cardiac muscle, renal parenchyma and mediastinum. Infiltration with giant cells, vascular thrombosis and eosinophilic necrosis of encompassing soft tissue is pathognomonic of mucormycosis. Serological assessment with enzyme linked immunosorbent assay (ELIZA), immunoblot or immunodiffusion assays and molecular assays as polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP) or DNA sequencing techniques are optimal for diagnosing mucormycosis. Appropriate therapy of mucormycosis is contingent to antecedent commencement of antifungal agents, treatment of comorbid conditions and debridement of infected tissue.
Application of Hybrid CTC/2D-Attention End-to-End Model in Speech Recognition during the COVID-19 Pandemic
Authors: Zhao Bin
Published: September 2022

Recent research in the field of speech recognition has shown that end-to-end speech recognition frameworks have greater potential than traditional frameworks. Aiming at the problem of unstable decoding performance in end-to-end speech recognition, a hybrid end-to-end model of connectionist temporal classification (CTC) and multi-head attention is proposed. CTC criterion was introduced to constrain2D-attention, and then the implicit constraint of CTC on 2D-attention distribution was realized by adjusting the weight ratio of the loss functions of the two criteria. On the 178h Aishell open source dataset, 7.237% word error rate was achieved. Experimental results show that the proposed end-to-end model has a higher recognition rate than the general end-to-end model, and has a certain advance in solving the problem of mandarin recognition.
In vivo Study of Proliferative Effect and Growth Promoting Effect of Ultra Diluted Phytolacca decandra in Chick Embryo by Using Cam Assay
Authors: MU Kathirvelraja
Published: September 2022

Homoeopathy and complementary integrative medicine treatments aimed at decreasing the side effects of anti-cancer therapy and cancer symptoms, as well as providing nutritional and lifestyle advice to help patients with breast cancer and enhance their quality of life. Angiogenesis can be used to investigate phase-specific processes in both physiological and pathological situations. Phytolacca decandra has a specific effect on breast cancer ulceration and scar tissue. The current study deals with the angiogenesis activity by using CAM Assay. Phytolacca decandra was taken in account and it increases angiogenesis in a CAM assay, indicating that it is not hazardous to normal cells. It also improves blood supply, which aids in proliferation, and has no side effects on normal cells.
Study on the Diet and Health Status of the Working Population of the Birhor, PVTG of Purulia
Authors: AG Roy
Published: September 2022

A tribe is an independent political division of a population with a common culture. Tribal people are primitive residents of our country. Tribal communities are isolated from the general population and are socially and economically disadvantaged. In view of their habitat and dietaryU habits, they often distinguish themselves from other population groups. Their food consumption pattern is influenced by varieties of nature and varies from extreme deprivation in the lean season to high levels of intake of several foods during the post-harvest period. Geographical isolation, primitive agricultural practices socio-cultural taboos, lack of formal education, poor infrastructure facilities, improper health-seeking behavior, poverty etc. leads to the development of various morbidities and undernutrition. For this study, 100 individuals from the Birhor community have been selected among which 50 are male and the rest are female. Some anthropometric measurements are taken for understanding the health status and to understand the nutritional status of daily food intake has been taken in a methodological procedure. The analysis of the study reveals that few age groups of this particular population remain undernourished, though the majority of them still belong to the normal nourished and healthy population group.
Applying the Indirect Immunofluorescent Antibody Test (IFAT) for Detection of Coxiella Burnetii in Chronic Hepatitis Patients and Fever of Unknown Origin Patients from the Village with Direct Contact with Animals in Assiut Governorate
Authors: SA Selim
Published: September 2022

Background: Q fever is a neglected zoonotic disease caused by the bacterium Coxiella burnetii. Although hepatitis is a one of the most presentations of Q fever, the attainable influence of chronic hepatitis C virus& hepatitis B virus, the apparent healthy person, and fever of unknown origin (FUO) in Q fever has, to our data, never been investigated. Clinical manifestation of Q fever in humans include cute, chronic to fatigue syndrome. It is a vital issue in regions where Q fever hepatitis and viral hepatitis are prevalent. Aim and Methods: We tend to conduct a study to research the possible attainable of viral hepatitis in cases of Q fever hepatitis. The serum samples were examined for IgM and IgG antibodies against C. burnetii antigen by indirect immunofluorescent antibody test (IFAT).The results showed that 20 patients with hepatitis C virus were studied, of whom 10(50%) IgM and 12 (60%) IgG had Q fever, A total of 40 patients with fever of unknown origin (FUO) studied (Patient suffer from fever, cough, rhinitis, nausea, vomiting (during winter), of whom 17 (42%) IgM and 18(45%) IgG had Q fever. Three samples from patients infected with Hepatitis B virus with kidney dialysis of whom 1(33%) IgM and IgG positive.10 samples from Apparent healthy persons of whom 3(30%) IgM positive 4(40%) IgG positive (females) one of them suffers from the reproductive disorder and another one suffer from toxic goitre. We concluded that we have a tend to terminate that the data on the medicine of Q fever in Egypt is proscribed with no attention to regulate and hindrance programs. The results of this study boost the data on the on the prevalence of fever of unknown origin (FUO). Corroding to our knowledge, Q fever influences the replication of hepatitis virus is continues to be not understood and wishes more studies.
Chondroid Syringoma: A Skin Adnexal Neoplasm Diagnosed on Aspiration Smears
Authors: I Chakrabarti
Published: September 2022

Chondroid syringomas are rare skin adnexal tumors which occur mostly in 20-80 year olds and commonly in the head and neck region with a male predilection. Here, we describe a 50-year old female patient presenting with subcutaneous swelling in the forehead. Fine needle aspiration revealed features of chondroid syringoma which was confirmed on subsequent histopathological examination. The present case highlights the importance of aspiration cytology for rapid, cheap and accurate diagnosis of these cutaneous neoplasms thus avoiding the necessity of invasive procedures.
Case Management Protocol and Tips to Manage Mental Health and Wellbeing during Corona Virus Disease-19 (COVID-19) Case Study
Authors: T Fentahun
Published: September 2022

A novel coronavirus (2019-nCoV) causing an outbreak of pneumonia in Wuhan, Hubei province of China was isolated in End of December, 2019. And nowadays it addressed almost more than 209 countries around the globe and spread very alarming rate. The objective of this paper was to increase the awareness of the community through informing the major preventive protocol technique and the way to applied during both pre-treatment and post treatment time in the struggle of this pandemic virus. And also, we tried to forward the basic techniques what we did during the lockdown period in order to avoid the overwhelmed feeling.
Role of Probiotics in Diabetes Mellitus
Authors: AR Yadav
Published: September 2022

Diabetes mellitus has become a serious concern as it is a major public health issue. Due to the complications like diabetic nephropathy, diabetic cardiovascular complication, diabetic neuropathy, diabetic retinopathy and diabetic heapatopathy it has high despondence and lethality. Depending on the health conditions of diabetic patients the present study shows the effects of probiotic complements. This review summarizes that by restraining intestinal microbiota along with decreasing the inflammatory reactions and oxidative stress probiotics can increase insulin sensitivity and reduces autoimmune reactions. Recent evidences show that probiotics affects the host through restraining intestinal permeability and mucosal immune response, employing eating behaviors by appetite-regulating hormones and controlling endocannabinoid (eCB) system that is correlated with inflammation and diabetes. It is hypothesized experimentally and clinically that restraining the microbiota by probiotics could be impressive in anticipation and execution of diabetes. Literature ascertained that the complementation of probiotics can avert and boost the T1DM, T2DM and gestational DM. In culmination probiotics have a lot of favorable effects in health and disease reducing superficial annoyance, regulating the immune system and improving the body antioxidant defense.
Covid-19 and Health Care Workers in Burkina Faso: Characteristics and Perceptions of their Management
Authors: Apolin Sondo K
Published: September 2022

Background: Health workers, engaged in the front line of the response to this pandemic, have inevitably been exposed to great risks of infection. Thus, in Burkina Faso, as in most countries, health workers have been infected. Objective: To study the characteristics and perceptions of their care management Methods: It was a descriptive cross-sectional study of health workers with COVID-19 from March to August 2020. All health workers with PCR-confirmed COVID-19 who consented to participate in the study were included. Results: Of the 62 health workers identified, the sex ratio was 0.82. The median age was 40.5 years with interquartile ranges of 36 and 52. Doctors (54.8%) and nurses (25.8%) were the most represented and 60% worked in university hospitals. Fifty- one health workers (82.3%) recalled having been infected, 41 (80.4%) of them in the course of their work. Thirty-three agents (53.2%) were hospitalised. Almost all health workers were symptomatic, frequently stigmatised in 61.3% of cases by their neighbors (60.5%) and their colleagues on duty (47.3%). The evolution was favorable for all health workers and psychosocial care was necessary for 22% of them. Conclusion: As health emergencies are becoming more and more frequent, health workers are vulnerable and it is crucial to put in place, all the necessary conditions to enable them to provide care without risk.
Monkeypox - Unravelling the On-going Stigma-A Mini Review
Authors: LJ Tadi
Published: September 2022

Introduction: The ongoing public health crises of monkeypox and poliomyelitis amidst the COVID-19 pandemic, have been straining both, the international as well as national health systems significantly. Despite having been first discovered in captive monkeys, thus the name, the information at hand points to the African rodents as the natural reservoir. Rats, mice, monkeys, prairie dogs, squirrels, and humans have all contracted infections [2]. Review: John P Thornhill et al. have reported 528 infections diagnosed between April 27 and June 24, 2022, at 43 sites in 16 countries. It has been reported that WHO officials are working on a new name for the virus and disease commonly known as monkeypox to reduce racism and stigma [1,8]. Owing to the fact of a very low CFR in this type, experts are of the view that the prevailing social stigma is that the monkeypox disease is transmitted sexually, especially through male-to-male sex, which dissuades people from reporting, despite developing symptoms [3,5,6]. Due to gay couples being a societal taboo, there are many unreported cases, hindering the testing process which may further lead to an unchecked spread in the country [6]. Researchers use the term, ‘HMPXV’ which stands for the human version of the monkeypox virus, referring to the virus driving the current outbreaks in Europe and North America, distinguishing it from those more commonly found in animals in Africa. According to the WHO, ‘names should be given with the aim to minimise the unnecessary negative impact on trade, travel, tourism, or animal welfare, and avoid causing offence to any cultural, social, national, regional, professional, or ethnic groups,’ as reported in the British Medical Journal (BMJ). Conclusion: Although monkeys are not the primary route of transmission, the disease is known as monkeypox because it was first observed in monkeys, by Danish scientists. Monkeypox is not known to be particularly contagious, and transmission often involves some level of close contact. Therefore, Monkeypox is not always transmitted sexually, though it is a form of intimate contact.
“A Logical Reasoning of Spongy Myocardium”- A Case of LV Non Compaction Cardiomyopathy
Authors: Sahi Ravi
Published: September 2022

Left ventricular noncompaction cardiomyopathy (LVNC) or spongy myocardium is a rare congenital disorder prominently distinguished by deep abnormal trabeculations and intertrabecular recesses which communicate with the ventricular cavity that can be detected on Transthoracic Echocardiography (TTE) or cardiac MRI (CMR) studies. LVNC can occur in isolation or coexists with other cardiac and/or systemic anomalies and the common clinical complications are heart failure, arrhythmias, and cardio embolism. The American Heart Association classified it as a primary genetic cardiomyopathy. We described the case of a 28years old young adult who presented with heart failure for the first time. Transthoracic echocardiography showed a trabeculated, sponge-like appearance of the ventricular apical and inferolateral segments. Following evaluation with CMR imaging revealed non compaction of the left ventricle. Here we discussed the diagnosis of this case and reviewed the medical literature that concerned to LVNC.
Anomalous Right Coronary Artery Origin from Left Sinus (R- ACAOS) Coronary Intervention Case Series; “Our Approach” - A Single Center Experience
Authors: Hirachan Anish
Published: September 2022

Anomalous origin of right coronary artery (RCA) from the left coronary sinus is very rare coronary anomaly. Various individual case reports and case series have been reported in the literature. Patients with anomalous right coronary artery may often be asymptomatic and detected on incidental CT coronary angiogram or at times may present with acute coronary syndrome, sudden cardiac death or malignant arrhythmias. Coronary intervention in an anomalous right coronary artery is often challenging and any interventionist should be familiar with the incidence of this anomaly and always choose an optimal, safe and a good co- axial guiding catheter support for a successful intervention. Here, we present three individual cases with anomalous RCA presenting with positive stress test to acute coronary syndrome. All three cases underwent successful intervention with Judkins left 3.0 (JL 3.0) guiding catheter without any perioperative complications.
Pulmonary Vasodilators in LVAD Patients:A Never-Ending Debate
Authors: Benedetto Maria
Published: September 2022

Left ventricular assist device is a life-saving option in patients with end-stage left heart failure. It leads to a decrease of pulmonary arterial pressure, wedge pressure and pulmonary vascular resistences. However, a post capillary pulmonary hypertension persists in a significant proportion of patients despite adequate LV unloading. A possible explanation is the pulmonary venous congestion and subsequent decrease in the level of nitric oxide. This observation has led to an increased interest for pulmonary vasodilators, especially phosphodiesterase 5 inhibitors (PD-5 I). They enhance the nitric oxide (NO) signaling through the increase of cyclic guanosine monophosphate availability. Sildenafil allows to tritate down the iNO and succesfully extubated the patient; it has been shown to significantly reduce mPAP and PVR 2-4 weeks after LVAD implantation and to wean from inotropic support within the first 72 hours. However, whereas literature seems to support its use in the immediate postoperative period, there are not enough evidences about their long term use.
Effect and Significance of Electrocardiographic Changes on Standing and Hyperventilation Prior to Exercise Electrocardiographic Testing
Authors: Mittal, SR
Published: September 2022

Electrocardiographic changes on standing from supine position and subsequent hyperventilation were studied in 100 persons. Changes were correlated with any evidence of myocardial ischemia during stress and/or recovery phase of treadmill stress testing. 15 individuals showed electrocardiographic changes on standing from supine position. Increase in heart rate of more than 30 beats per minute without a fall of more than 20 mm Hg in systolic blood pressure was seen in three cases. Two of them developed ischemic changes during exercise. Decrease in R wave amplitude in leads V2 to V6 was seen in one individual who developed ischemic changes during exercise. New inversion of T waves in leads V2 to V4 in a case with pre-existing RBBB and inverted T wave becoming positive in lead V2 were also associated with electrocardiographic evidence of myocardial ischemia during exercise testing. Mild change in QRS axis, decrease in R wave amplitude in leads II, III, aVF and/or V3 to V5 , ST segment depression of less than 1 mm and decrease in amplitude or inversion of T waves in leads II, III, aVF and V1 to V6 did not have any correlation with evidence of myocardial ischemia during exercise. Fourteen persons showed new electrocardiographic changes during hyperventilation after standing. Three cases had decrease in heart rate. All the three had evidence of myocardial ischemia during treadmill testing. Increase in amplitude of R wave in lead V4, normalization of pre-excitation with unmasking of old myocardial infarction and ST segment depression of more than 2 mm in inferior and lateral precordial leads with ST segment elevation in lead aVR were also associated with development of ECG evidence of myocardial ischemia during treadmill testing. Decrease in R wave amplitude in leads II, III, aVF and/or V4 - V6 , ST segment depression of less than 1mm in inferior or lateral precordial leads and inversion of T waves did not have any significant correlation with development of electrocardiographic signs of myocardial ischemia during treadmill stress test.