bluuebunny/crossref_metadata_2025 huggingface dataset:
Maternal Factors and the Utilization of Maternal Care Services Associated with Infant Feeding Practices among Mothers in Rural Southern Nepal
Authors: Acharya Dilaram , Singh Jitendra Kumar , Kandel Rajendra , Park Ji-Hyuk , Yoo Seok-Ju , Lee Kwan
Published: May 2019

This study aimed to investigate the maternal factors and utilization of maternal care services associated with infant feeding practices in rural areas of Southern Nepal. Data from a cluster randomized controlled trial ‘MATRI-SUMAN’(Maternal Alliance for Technological Research Initiative on Service Utilization and Maternal Nutrition) conducted between 2015–2016 were analyzed. A total of 426 pregnant women in their second trimester were recruited from the MATRI-SUMAN trial, which was conducted on six villages in rural areas of the Dhanusha district, Nepal. A total of 379 mothers that had ever breastfed their infants, and followed for at least seven months after birth were included in the analysis. Multivariate logistic regression analysis was used to identify independent risk factors associated with child feeding practices after controlling for potential confounders. Of the 379 mothers, 41.4%, 53%, and 43% initiated breast feeding within the first hour of birth (EIBF), practiced exclusive breastfeeding (EBF), and initiated timely complementary feeding (CF) at six months, respectively. Multiple logistic regression results revealed that maternal education (secondary or higher), an occupation in the service/business/household sectors, receipt of MATRI-SUMAN intervention, more than four ANC (antenatal care) visits, and delivery in a health facility were associated with higher odds ratios of EIBF. Similarly, mothers with a primary, secondary and higher level of education, that worked in the service/business/household sectors, primiparous mothers, those that received MATRI-SUMAN intervention, visited ANC more than four times, and made a PNC (postnatal care) visit had higher odds ratios of EBF, while mothers who were 35–45 years of age were less likely to have used EBF. In addition, education to the secondary or a higher level, a male baby, receipt of MATRI-SUMAN intervention and a PNC visit had higher odds ratios of CF initiation at six months. The promotion of maternal ANC visits, birth at a health institution, and postnatal visits should be recommended in order to improve child feeding practices in Nepal.
Immunoglobulin Binding Protein 1 as a Potential Urine Biomarker in Patients with Lupus Nephritis
Authors: Lee Eun-Ju , Kwon Oh Chan , Ghang Byeongzu , Lim Doo-Ho , Kim Do Hoon , Hong Seokchan , Lee Chang-Keun , Yoo Bin , Kim Yong-Gil
Published: May 2019

We evaluated the role of immunoglobulin binding protein 1 (IGBP1), a phosphoprotein associated with the B cell receptor (BCR) complex, as a urine biomarker in lupus nephritis (LN). The IGBP1 concentrations in plasma and urine of patients with LN, systemic lupus erythematosus (SLE) without nephritis and healthy controls were estimated by ELISA. IGBP1 expression in the kidneys of LN patients and transplantation donors was detected by immunohistochemistry. Microarray-based global gene expression profile of HK-2 cells with IGBP1 knock-down and fluorescence-activated cell sorting (FACS) for intracellular IGBP1 expression in human peripheral blood mononuclear cells (PBMCs) was performed. Urine IGBP1 levels were elevated significantly in LN patients, and it correlated with the clinical activity indices (complement 3 (C3) level, anti-dsDNA antibodies titer, SLE Disease Activity Index-2000 (SLEDAI-2K) and histological activity index. IGBP1 expression was increased in LN patients as compared to the donors and was detected mainly in the tubules by histopathology. In microarray analysis, several genes related to SLE pathogenesis (PPME1, ROCK2, VTCN1, IL-17R, NEU1, HLA-DM, and PTX3) responded to siRNA-mediated IGBP1 silencing. In FACS, IGBP1 was expressed mainly in the CD14+ cells. The overall expression of IGBP1 in PBMCs was higher in LN patients as compared with that in SLE patients without nephritis. Conclusively, urinary IGBP1 may be a novel biomarker reflecting the clinical and histological activities in LN.
Effect of Peritoneal Dialysis on Serum Fibrosis Biomarkers in Patients with Refractory Congestive Heart Failure
Authors: Kunin Margarita , Carmon Vered , Beckerman Pazit , Dinour Dganit
Published: May 2019

Background: Cardiac collagen remodeling is important in the progression of heart failure. Estimation of cardiac collagen turnover by serum levels of serological markers is used for monitoring cardiac tissue repair and fibrosis. Peritoneal dialysis (PD) is used for the long-term management of refractory congestive heart failure (CHF). In this study, we investigated the effect of PD treatment on circulating fibrosis markers levels in patients with refractory CHF and fluid overload. Methods: Twenty-five patients with refractory CHF treated with PD were prospectively enrolled in the study. Circulating fibrosis markers procollagen type III C-peptide (PIIINP), matrix metalloproteinase 2 (MMP-2), and tissue inhibitor of metalloproteinases I (TIMP-1) levels were checked at baseline and after three and six months of treatment. Results: The clinical benefit of PD manifested by improved NYHA functional class and reduced hospitalization rate. Serum brain natriuretic peptide (BNP) levels decreased significantly during the treatment. Serum MMP-2 and TIMP-1 decreased significantly on PD. Circulating PIIINP showed two patterns of change, either decreased or increased following PD treatment. Patients in whom circulating PIIINP decreased had significantly lower baseline serum albumin, lower baseline mean arterial blood pressure, higher serum CRP, and a less significant improvement in hospitalization rate compared to the patients in whom circulating PIIINP increased. Patients in whom all three markers decreased demonstrated a trend to longer survival compared to patients whose markers increased or did not change. Conclusion: In refractory CHF patients PD treatment was associated with a reduction in circulating fibrosis markers.
Deoxypodophyllotoxin Exerts Anti-Cancer Effects on Colorectal Cancer Cells Through Induction of Apoptosis and Suppression of Tumorigenesis
Authors: Gamage Chathurika D. B. , Park So-Yeon , Yang Yi , Zhou Rui , Taş İsa , Bae Woo Kyun , Kim Kyung Keun , Shim Jung-Hyun , Kim Eunae , Yoon Goo , Kim Hangun
Published: May 2019

Deoxypodophyllotoxin (DPT) is a cyclolignan compound that exerts anti-cancer effects against various types of cancers. DPT induces apoptosis and inhibits the growth of breast, brain, prostate, gastric, lung, and cervical tumors. In this study, we sought to determine the effect of DPT on cell proliferation, apoptosis, motility, and tumorigenesis of three colorectal cancer (CRC) cell lines: HT29, DLD1, and Caco2. DPT inhibited the proliferation of these cells. Specifically, the compound-induced mitotic arrest in CRC cells by destabilizing microtubules and activating the mitochondrial apoptotic pathway via regulation of B-cell lymphoma 2 (Bcl-2) family proteins (increasing Bcl-2 associated X (BAX) and decreasing B-cell lymphoma-extra-large (Bcl-xL)) ultimately led to caspase-mediated apoptosis. In addition, DPT inhibited tumorigenesis in vitro, and in vivo skin xenograft experiments revealed that DPT significantly decreased tumor size and tumor weight. Taken together, our results suggest DPT to be a potent compound that is suitable for further exploration as a novel chemotherapeutic for human CRC.
LncRNAs Regulatory Networks in Cellular Senescence
Authors: Puvvula Pavan Kumar
Published: May 2019

Long noncoding RNAs (lncRNAs) are a class of transcripts longer than 200 nucleotides with no open reading frame. They play a key role in the regulation of cellular processes such as genome integrity, chromatin organization, gene expression, translation regulation, and signal transduction. Recent studies indicated that lncRNAs are not only dysregulated in different types of diseases but also function as direct effectors or mediators for many pathological symptoms. This review focuses on the current findings of the lncRNAs and their dysregulated signaling pathways in senescence. Different functional mechanisms of lncRNAs and their downstream signaling pathways are integrated to provide a bird’s-eye view of lncRNA networks in senescence. This review not only highlights the role of lncRNAs in cell fate decision but also discusses how several feedback loops are interconnected to execute persistent senescence response. Finally, the significance of lncRNAs in senescence-associated diseases and their therapeutic and diagnostic potentials are highlighted.
Risk Factors and Emerging Therapies in Amyotrophic Lateral Sclerosis
Authors: Nowicka Natalia , Juranek Jakub , Juranek Judyta K. , Wojtkiewicz Joanna
Published: May 2019

Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease characterized by a permanent degeneration of both upper and lower motor neurons. Many different genes and pathophysiological processes contribute to this disease, however its exact cause remains unclear. Therefore, it is necessary to understand this heterogeneity to find effective treatments. In this review, we focus on selected environmental and genetic risk factors predisposing to ALS and highlight emerging treatments in ALS therapy. Of numerous defective genes associated with ALS, we focus on four principal genes that have been identified as definite causes of ALS: the SOD1 gene, C9orf72, TDP-43, as well as the recently identified TBK1. We also provide up-to-date information on selected environmental factors that have historically been considered as key players in ALS development and pathogenesis. In parallel to our survey of known risk factors, we also discuss emerging ALS stem cell therapies and experimental medicines currently undergoing phase II and III clinical trials.
Recent Advances in Inflammation and Treatment of Small Airways in Asthma
Authors: Zinellu Elisabetta , Piras Barbara , Ruzittu Giulia G. M. , Fois Sara S. , Fois Alessandro G. , Pirina Pietro
Published: May 2019

Small airways were historically considered to be almost irrelevant in the development and control of pulmonary chronic diseases but, as a matter of fact, in the past few years we have learned that they are not so “silent”. Asthma is still a worldwide health issue due to the great share of patients being far from optimal management. Several studies have shown that the deeper lung inflammation plays a critical role in asthma pathogenesis, mostly in these not well-controlled subjects. Therefore, assessing the degree of small airways inflammation and impairment appears to be a pivotal step in the asthmatic patient’s management. It is now possible to evaluate them through direct and indirect measurements, even if some obstacles still affect their clinical application. The success of any treatment obviously depends on several factors but reaching the deeper lung has become a priority and, for inhaled drugs, this is strictly connected to the molecule’s size. The aim of the present review is to summarize the recent evidence concerning the small airway involvement in asthma, its physiopathological characteristics and how it can be evaluated in order to undertake a personalized pharmacological treatment and achieve a better disease control.
Hiseq Base Molecular Characterization of Soil Microbial Community, Diversity Structure, and Predictive Functional Profiling in Continuous Cucumber Planted Soil Affected by Diverse Cropping Systems in an Intensive Greenhouse Region of Northern China
Authors: Ali Ahmad , Imran Ghani Muhammad , Li Yuhong , Ding Haiyan , Meng Huanwen , Cheng Zhihui
Published: May 2019

Cover crops are key determinants of the ecological stability and sustainability of continuous cropping soils. However, their agro-ecological role in differentially reshaping the microbiome structure and functioning under a degraded agroecosystem remains poorly investigated. Therefore, structural and metabolic changes in soil bacterial community composition in response to diverse plant species were assessed. Winter catch leafy vegetables crops were introduced as cover plants in a cucumber-fallow period. The results indicate that cover crop diversification promoted beneficial changes in soil chemical and biological attributes, which increased crop yields in a cucumber double-cropping system. Illumina high-throughput sequencing of 16S rRNA genes indicated that the bacterial community composition and diversity changed through changes in the soil properties. Principal component analysis (PCA) coupled with non-metric multidimensional scaling (NMDS) analysis reveals that the cover planting shaped the soil microbiome more than the fallow planting (FC). Among different cropping systems, spinach–cucumber (SC) and non-heading Chinese cabbage–cucumber (NCCC) planting systems greatly induced higher soil nutrient function, biological activity, and bacterial diversity, thus resulting in higher cucumber yield. Quantitative analysis of linear discriminant analysis effect size (LEfSe) indicated that Proteobacteria, Actinobacteria, Bacteroidetes, and Acidobacteria were the potentially functional and active soil microbial taxa. Rhizospheres of NCCC, leaf lettuce–cucumber (LLC), coriander–cucumber (CC), and SC planting systems created hotspots for metabolic capabilities of abundant functional genes, compared to FC. In addition, the predictive metabolic characteristics (metabolism and detoxification) associated with host–plant symbiosis could be an important ecological signal that provides direct evidence of mediation of soil structure stability. Interestingly, the plant density of non–heading Chinese cabbage and spinach species was capable of reducing the adverse effect of arsenic (As) accumulation by increasing the function of the arsenate reductase pathway. Redundancy analysis (RDA) indicated that the relative abundance of the core microbiome can be directly and indirectly influenced by certain environmental determinants. These short-term findings stress the importance of studying cover cropping systems as an efficient biological tool to protect the ecological environment. Therefore, we can speculate that leafy crop diversification is socially acceptable, economically justifiable, and ecologically adaptable to meet the urgent demand for intensive cropping systems to promote positive feedback between crop–soil sustainable intensification.
iTRAQ-Based Quantitative Analysis of Responsive Proteins Under PEG-Induced Drought Stress in Wheat Leaves
Authors: Wang Yajing , Zhang Xinying , Huang Guirong , Feng Fu , Liu Xiaoying , Guo Rui , Gu Fengxue , Zhong Xiuli , Mei Xurong
Published: May 2019

Drought is an important abiotic stress that seriously restricts crop productivity. An understanding of drought tolerance mechanisms offers guidance for cultivar improvement. In order to understand how a well-known wheat genotype Jinmai 47 responds to drought, we adopted the iTRAQ and LC/MS approaches and conducted proteomics analysis of leaves after exposure to 20% of polyethylene glycol-6000 (PEG)-induced stress for 4 days. The study identified 176 differentially expressed proteins (DEPs), with 65 (36.5%) of them being up-regulated, and 111 (63.5%) down-regulated. DEPs, located in cellular membranes and cytosol mainly, were involved in stress and redox regulation (51), carbohydrate and energy metabolism (36), amino acid metabolism (24), and biosynthesis of other secondary metabolites (20) primarily. Under drought stress, TCA cycle related proteins were up-regulated. Antioxidant system, signaling system, and nucleic acid metabolism etc. were relatively weakened. In comparison, the metabolism pathways that function in plasma dehydration protection and protein structure protection were strongly enhanced, as indicated by the improved biosynthesis of 2 osmolytes, sucrose and Proline, and strongly up-regulated protective proteins, LEA proteins and chaperones. SUS4, P5CSs, OAT, Rab protein, and Lea14-A were considered to be important candidate proteins, which deserve to be further investigated.
Mechanistic and Kinetic Study on Self-/Cross- Condensation of PCTA/DT Formation Mechanisms from Three Types of Radicals of 2,4-Dichlorothiophenol
Authors: Wang Hetong , Zuo Chenpeng , Zheng Siyuan , Sun Yanhui , Xu Fei , Zhang Qingzhu
Published: May 2019

Chlorothiophenols (CTPs) are known to be key and direct precursors of polychlorinated thianthrene/dibenzothiophenes (PCTA/DTs). Self/cross-coupling of the chlorothiophenoxy radicals (CTPRs), sulfydryl-substituted phenyl radicals and thiophenoxyl diradicals evolving from CTPs are initial and important steps for PCTA/DT formation. In this study, quantum chemical calculations were carried out to investigate the homogenous gas-phase formation of PCTA/DTs from self/cross-coupling of 2,4-dichlorothiophenoxy radical (R1), 2-sulfydryl-3,5-dichlorophenyl radical (R2) and 3,5-dichlorothiophenoxyl diradical (DR) at the MPWB1K/6-311+G(3df,2p)//MPWB1K/6-31+G(d,p) level. The rate constants of crucial elementary steps were deduced over 600–1200 K, using canonical variational transition state theory with a small curvature tunneling contribution. For the formation of PCTAs, the S•/σ-C• condensation with both thiophenolic sulfur in one radical and ortho carbon in the other radical bonded to single electron is the most efficient sulfur-carbon coupling mode, and the ranking of the PCTA formation potential is DR + DR > R2 + DR > R1 + DR > R1 + R2 > R1 + R1. For the formation of PCDTs, the σ-C•/σ-C• coupling with both ortho carbon in the two radicals bonded to single electron is the energetically favored carbon-carbon coupling mode, and the ranking of the PCDT formation potential is: R2 + DR > R2 + R2 > R1 + DR > R1 + R2 > R1 + R1. The PCTA/DTs could be produced from R1, R2 and DR much more readily than PCDD/DFs from corresponding oxygen substituted radicals.
A Hypergraph Data Model for Expert-Finding in Multimedia Social Networks
Authors: Amato Flora , Cozzolino Giovanni , Sperlì Giancarlo
Published: May 2019

Online Social Networks (OSNs) have found widespread applications in every area of our life. A large number of people have signed up to OSN for different purposes, including to meet old friends, to choose a given company, to identify expert users about a given topic, producing a large number of social connections. These aspects have led to the birth of a new generation of OSNs, called Multimedia Social Networks (MSNs), in which user-generated content plays a key role to enable interactions among users. In this work, we propose a novel expert-finding technique exploiting a hypergraph-based data model for MSNs. In particular, some user-ranking measures, obtained considering only particular useful hyperpaths, have been profitably used to evaluate the related expertness degree with respect to a given social topic. Several experiments on Last.FM have been performed to evaluate the proposed approach’s effectiveness, encouraging future work in this direction for supporting several applications such as multimedia recommendation, influence analysis, and so on.
Snail1: A Transcriptional Factor Controlled at Multiple Levels
Authors: Baulida Josep , Díaz Víctor M. , García de Herreros Antonio
Published: May 2019

Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition and fibroblast activation. As a consequence, Snail1 expression and function is regulated at multiple levels from gene transcription to protein modifications, affecting its interaction with specific cofactors. In this review, we describe the different elements that control Snail1 expression and its activity both as transcriptional repressor or activator.
High Normal Range of Free Thyroxine is Associated with Decreased Triglycerides and with Increased High-Density Lipoprotein Cholesterol Based on Population Representative Data
Authors: Lee Jeongmin , Ha Jeonghoon , Jo Kwanhoon , Lim Dong-Jun , Lee Jung-Min , Chang Sang-Ah , Kang Moo-Il , Kim Min-Hee
Published: May 2019

Background: We aimed to evaluate the association between thyroid hormone (free thyroxine, free T4) level and lipid profiles in nationally representative data. Methods: This study was based on cross-sectional survey data from the sixth Korea National Health and Nutrition Examination Survey IV. After exclusion of subjects with a history of thyroid disease or abnormal thyroid function test and those on medication for dyslipidemia and/or cardiovascular disease, a total of 3548 subjects were included in the study. Results: There was a significant decrease in serum triglyceride levels and increase in serum high-density lipoprotein (HDL) cholesterol levels with high free T4 quartiles after adjustment for confounding factors (p for trend = 0.001 and p for trend = 0.014, respectively). Risk of hypertriglyceridemia was significantly decreased (odds ratio of 0.72 (95% confidential interval 0.53–0.98)) in the highest free T4 quartile compared to the lowest free T4 quartile, p = 0.044). Conclusions: Serum free T4 levels within normal range negatively correlated with serum triglyceride level and positively correlated with HDL-cholesterol level. Therefore, a close surveillance in terms of lipid profiles could be considered in subjects with low normal serum free T4 levels.
Evaluation and Modeling of the Fatigue Damage Behavior of Polymer Composites at Reversed Cyclic Loading
Authors: Koch Ilja , Just Gordon , Brod Martin , Chen Jiuheng , Doblies Audrius , Dean Aamir , Gude Maik , Rolfes Raimund , Hopmann Christian , Fiedler Bodo
Published: May 2019

Understanding the composite damage formation process and its impact on mechanical properties is a key step towards further improvement of material and higher use. For its accelerated application, furthermore, practice-related modeling strategies are to be established. In this collaborative study, the damage behavior of carbon fiber-reinforced composites under cyclic loading with load reversals is analyzed experimentally and numerically. The differences of crack density evolution during constant amplitude and tension-compression block-loading is characterized with the help of fatigue tests on cross-ply laminates. For clarifying the evolving stress-strain behavior of the matrix during static and fatigue long-term loading, creep, and fatigue experiments with subsequent fracture tests on neat resin samples are applied. The local stress redistribution in the composite material is later evaluated numerically using composite representative volume element (RVE) and matrix models under consideration of viscoelasticity. The experimental and numerical work reveals the strong influence of residual stresses and the range of cyclic tension stresses to the damage behavior. On the microscopic level, stress redistribution dependent on the mean stress takes place and a tendency of the matrix towards embrittlement was found. Therefore, it is mandatory to consider stress amplitude and means stress as inseparable load characteristic for fatigue assessment, which additionally is influenced by production-related and time-dependent residual stresses. The phenomenological findings are incorporated to a numerical simulation framework on the layer level to provide an improved engineering tool for designing composite structures.
Porosity Distribution in Apically Perforated Curved Root Canals Filled with Two Different Calcium Silicate Based Materials and Techniques: A Micro-Computed Tomography Study
Authors: Drukteinis Saulius , Peciuliene Vytaute , Shemesh Hagay , Tusas Paulius , Bendinskaite Ruta
Published: May 2019

The present study evaluated the porosity distribution of BioRoot RCS/single gutta-percha point (BR/SC) and MTA flow (MF) fillings, which were used as plugs for the apical perforation repair in curved canals of extracted mandibular molars using micro-computed tomography (μCT). Forty mesial root canals of mandibular first molars were shaped with ProTaper NEXT X1–X5 files 2 mm beyond the apex to simulate apical perforations that were randomly divided into two groups (n = 20) according to the material and technique used for the apical plug: BR/SC or MF. The specimens were scanned before and after canal filling at an isotropic resolution of 9.9 μm. The volumetric analysis of voids in the apical 5 mm of the fillings was performed. Data were analyzed using one-way ANOVA with Bonferroni correction (p < 0.05). Micro-computed tomography (µCT) evaluation revealed significant differences between the groups in terms of porosity: the total volume and percentage volume of voids was lower in the BR/SC group in comparison with the MF group (p < 0.05), with the predominance of open pores in both groups. Neither of the materials and/or application techniques were able to produce void-free root fillings in the apical region of artificially perforated curved roots of mandibular molars.
Microstructure Evolution and Nanotribological Properties of Different Heat-Treated AISI 420 Stainless Steels after Proton Irradiation
Authors: Dai L.Y. , Niu G.Y. , Ma M.Z.
Published: May 2019

In this paper, low-energy proton irradiation experiments with different cumulative fluences were performed on samples of AISI 420 stainless steel that were either annealed or tempered at 600 or 700 °C. The effects of the cumulative proton irradiation fluence on the evolution of the microstructure of AISI 420 were studied by transmission electron microscopy (TEM). Scratch tests were performed using a Tribo Indenter nanomechanical tester, in order to investigate the effects of the cumulative fluence on the tribological properties of the AISI 420 stainless steel. The results indicate that the dislocation density of the microstructure near the surface of the AISI 420 stainless steel increases with higher cumulative proton irradiation fluences. Under the same load, the nanoscale friction coefficient and wear rate both decreased with increasing cumulative proton irradiation fluence. This indicates that the surface hardening effect induced by proton irradiation can diminish the nanoscale friction coefficient and wear rate.
Some New Fractional-Calculus Connections between Mittag–Leffler Functions
Authors: Srivastava Hari M. , Fernandez Arran , Baleanu Dumitru
Published: May 2019

We consider the well-known Mittag–Leffler functions of one, two and three parameters, and establish some new connections between them using fractional calculus. In particular, we express the three-parameter Mittag–Leffler function as a fractional derivative of the two-parameter Mittag–Leffler function, which is in turn a fractional integral of the one-parameter Mittag–Leffler function. Hence, we derive an integral expression for the three-parameter one in terms of the one-parameter one. We discuss the importance and applications of all three Mittag–Leffler functions, with a view to potential applications of our results in making certain types of experimental data much easier to analyse.
Logistic Growth Described by Birth-Death and Diffusion Processes
Authors: Di Crescenzo Antonio , Paraggio Paola
Published: May 2019

We consider the logistic growth model and analyze its relevant properties, such as the limits, the monotony, the concavity, the inflection point, the maximum specific growth rate, the lag time, and the threshold crossing time problem. We also perform a comparison with other growth models, such as the Gompertz, Korf, and modified Korf models. Moreover, we focus on some stochastic counterparts of the logistic model. First, we study a time-inhomogeneous linear birth-death process whose conditional mean satisfies an equation of the same form of the logistic one. We also find a sufficient and necessary condition in order to have a logistic mean even in the presence of an absorbing endpoint. Then, we obtain and analyze similar properties for a simple birth process, too. Then, we investigate useful strategies to obtain two time-homogeneous diffusion processes as the limit of discrete processes governed by stochastic difference equations that approximate the logistic one. We also discuss an interpretation of such processes as diffusion in a suitable potential. In addition, we study also a diffusion process whose conditional mean is a logistic curve. In more detail, for the considered processes we study the conditional moments, certain indices of dispersion, the first-passage-time problem, and some comparisons among the processes.
Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio and Complete Blood Count Components in the First Trimester Do Not Predict HELLP Syndrome
Authors: Sisti Giovanni , Faraci Andrea , Silva Jessica , Upadhyay Ruchi
Published: May 2019

Background and Objectives: Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), and other components of the routine complete blood count (CBC) were found to be sensitive biomarkers of preeclampsia and other inflammatory obstetric conditions in previous studies, with conflicting results. We speculated that the same associations existed with hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome in the first trimester of pregnancy. Materials and Methods: We conducted a retrospective case–control study at a tertiary care hospital in NY (USA), in the time frame between January 2016 and December 2018. Our population consisted of pregnant women in the first trimester: We compared patients with HELLP syndrome (cases) with healthy patients (controls) matched by age, body mass index (BMI), parity, and race. Patients with preeclampsia, infection, and fever were excluded. Venous blood samples were obtained as part of the routine work-up during the first prenatal visit in the first trimester, which includes a CBC. The main outcomes were NLR and PLR, and the secondary outcomes were hemoglobin, RDW, platelet count, MPV, neutrophils, and lymphocytes. Results: There were 10 patients in each group. There were no differences in NLR and PLR levels and other CBC components between the two groups. Conclusions: In our study NLR, PLR, and other CBC components did not predict HELLP syndrome. We speculate that HELLP syndrome has a sudden increase of tissue inflammation in the third trimester that is not manifested during the early phases of placentation. Larger studies are needed to evaluate the true ability of NLR, PLR, and CBC components to predict HELLP syndrome in the first trimester.
Magnesium Matrix Composite with Open-Celled Glassy Carbon Foam Obtained Using the Infiltration Method
Authors: Olszówka-Myalska Anita , Godzierz Marcin , Myalski Jerzy , Wrześniowski Patryk
Published: May 2019

In this study, we present a new composite material that was developed using the pressure infiltration method. In this composite, carbon reinforcement in the form of an open-celled rectangular foam (Cof) was applied, and pure magnesium with two commercial magnesium cast alloys (AZ31, RZ5) was used as the matrix. We examined the microstructure (LM, SEM + EDS) of composites as well as the density, porosity, hardness, compressive strength, flexural strength and tribological properties in dry conditions. It was revealed that the chemical composition of the matrix had a significant impact on the macrostructure, microstructure and properties of the composite. The matrix with rare elements (RZ5) induced poor infiltration of Cof and physicochemical degradation of the reinforcement, while pure magnesium ensured good infiltration, a stable friction coefficient and low wear. For the AZ31 alloy, the effects of infiltration were good; however, an increase in the tribological properties was not observed. Compared with the as-cast matrix materials, the presence of carbon foam in both pure Mg and AZ31 alloy induced an increase in compressive strength and stiffness as well as a decrease in flexural strength. Furthermore, SEM examination of the fractured and wear surfaces microstructure showed structural effects’ dependence on the matrix composition.
Fabrications of L-Band LiNbO3-Based SAW Resonators for Aerospace Applications
Authors: Hu Baofa , Zhang Shaoda , Zhang Hong , Lv Wenlong , Zhang Chunquan , Lv Xueqin , San Haisheng
Published: May 2019

High frequency surface acoustic wave (SAW) technology offers many opportunities for aerospace applications in passive wireless sensing and communication. This paper presents the design, simulation, fabrication, and test of an L-band SAW resonator based on 128° Y-X LiNbO3 substrate. The design parameters of SAW resonator were optimized by the finite element (FEM) method and the coupling-of-mode (COM) theory. Electron-beam lithography (EBL) technology was used to fabricate the submicron-scale of interdigital transducers (IDTs) and grating reflectors. The effects of some key EBL processes (e.g., the use of electron beam resist, the choice of metal deposition methods, the charge-accumulation effect, and the proximity-effect) on the fabrication precision of SAW devices were discussed. Experimentally, the LiNbO3-based SAW resonators fabricated using improved EBL technology exhibits a Rayleigh wave resonance peaks at 1.55 GHz with return loss about −12 dB, and quality factor Q is 517. Based on this SAW resonator, the temperature and strain sensing tests were performed, respectively. The experimental results exhibit a well linear dependence of temperature/strain on frequency-shift, with a temperature sensitivity of 125.4 kHz/°C and a strain sensitivity of −831 Hz/με, respectively.
Investigation on Cutting Performance of Micro-Textured Cutting Tools
Authors: Li Qinghua , Pan Chen , Jiao Yuxin , Hu Kaixing
Published: May 2019

This paper explores the influence of micro textures on cutting performance of polycrystalline cubic boron nitride (PCBN) tools from two aspects, that is, tool wear and machined surface roughness. By designing micro-hole textures with different forms and scales on the rake face of tools when PCBN tools turn hardened steel GCr15, and combining finite element analysis (FEA) technology and cutting experiments, the cutting performance of micro-textured tools is simulated and analyzed. This paper analyses the influence of micro textures on tool wear and machined surface roughness by analyzing cutting force, Mises stress and maximum shear stress of tool surface. Results of finite element analysis (FEA) and cutting experiments show that the reasonable micro-hole textures can significantly alleviate tool wear and improve machined surface quality when compared with the non-textured tools. Besides, the size of micro-hole textures on the rake face play an important role in reducing the cutting force and tool wear. This is mainly because micro-hole textures can reduce cutting force and improve tool surface stress. Finally, by designing reasonable micro-hole textures on the rake face, the problems of bad roughness of machined workpiece and severe tool wear of PCBN tools in cutting GCr15 material are solved. Consequently, the paper shows that micro-hole textures have a positive effect on improving the cutting performance of tool.
Nanocrystalline Principal Slip Zones and Their Role in Controlling Crustal Fault Rheology
Authors: Verberne Berend A. , Plümper Oliver , Spiers Christopher J.
Published: May 2019

Principal slip zones (PSZs) are narrow (<10 cm) bands of localized shear deformation that occur in the cores of upper-crustal fault zones where they accommodate the bulk of fault displacement. Natural and experimentally-formed PSZs consistently show the presence of nanocrystallites in the <100 nm size range. Despite the presumed importance of such nanocrystalline (NC) fault rock in controlling fault mechanical behavior, their prevalence and potential role in controlling natural earthquake cycles remains insufficiently investigated. In this contribution, we summarize the physical properties of NC materials that may have a profound effect on fault rheology, and we review the structural characteristics of NC PSZs observed in natural faults and in experiments. Numerous literature reports show that such zones form in a wide range of faulted rock types, under a wide range of conditions pertaining to seismic and a-seismic upper-crustal fault slip, and frequently show an internal crystallographic preferred orientation (CPO) and partial amorphization, as well as forming glossy or “mirror-like” slip surfaces. Given the widespread occurrence of NC PSZs in upper-crustal faults, we suggest that they are of general significance. Specifically, the generally high rates of (diffusion) creep in NC fault rock may play a key role in controlling the depth limits to the seismogenic zone.
Comparative Study on Surface Structure, Electronic Properties of Sulfide and Oxide Minerals: A First-Principles Perspective
Authors: Cui Weiyong , Zhang Yibing , Chen Jianhua , Zhao Cuihua , Li Yuqiong , Chen Ye , Lee Ming-Hsien
Published: May 2019

First-principle calculations were used to investigate the surface structure and electronic properties of sulfide (pyrite, galena, and sphalerite) and oxide minerals (hematite, cerussite, and smithsonite). Surface relaxation and Femi energy, as well as projected DOS, are considered. Results show that the surface atoms of the sulfide minerals are more susceptible and more easily affected by the fracture bonds. The sulfide surfaces possess higher chemical potential than the corresponding oxide surfaces, and are more likely to be electron donors in reactions. The S 3p states are the mainly contributing states in the sulfide surface, while that in the oxide surface are O 2p states. The bonds of the sulfide surface have more covalent features and that of the oxide surface are ionic interactions. The O–M (M represents Fe, Pb or Zn) bonds are more stable, as the DOS of the oxide surfaces distribute in the lower energy range.
Sequential Bioleaching of Phosphorus and Uranium
Authors: Mäkinen Jarno , Wendling Laura , Lavonen Tiina , Kinnunen Päivi
Published: May 2019

Phosphorus and uranium are both vital elements for society. In recent decades, fears have arisen about the future availability of low-cost phosphorus and uranium. This has resulted in pressure to de-centralize production of both elements by utilizing lower-grade or complex deposits. The research presented here focused on phosphorus-containing apatite ores with uranium impurities; in order to separate uranium by selective and sequential bioleaching before phosphorus leaching. This would create an alternative process route for solvent-extraction, used to remove/recover uranium from the phosphorus acid product of apatite H2SO4 wet process. In this work, it was seen that the used fluorapatite ore required 24 h leaching at pH 1 by H2SO4 to result in 100% leaching yield for phosphorus. As this ore did not contain much uranium, an artificial fluorapatite-uranium ore was prepared by mixing standard uranium ore and fluorapatite. The research with this ore showed that 89% of uranium dissolved in 3 days at pH > 2 and leaching was improved by applying Fe3+ oxidant. In these conditions only 4% of phosphorus was leached. By prolonged (28 days) leaching 95% uranium yield was reached. According to the experiments, the iron in the uranium leach solution would be mainly Fe3+, which allows the use of H2O2 for uranium recovery and then direct use of spent leachate for another uranium leaching cycle. After the dissolution of uranium, 90% of phosphorus was dissolved by decreasing the pH to 1.3. This was done by bioleaching, by utilizing biogenic sulfur oxidation to sulfuric acid.
Synthesis and Chemical Properties of 3-Phosphono-coumarins and 1,2-Benzoxaphosphorins as Precursors for Bioactive Compounds
Authors: Koleva Ana I. , Petkova-Yankova Nevena I. , Nikolova Rositca D.
Published: May 2019

Coumarins are an important class of natural heterocyclic compounds that have attracted considerable synthetic and pharmacological interest due to their various biological activities. This review emphasizes on the synthetic methods for the preparation of dialkyl 2-oxo-2H-1-benzo- pyran-3-phosphonates and alkyl 1,2-benzoxaphosphorin-3-carboxylates. Their chemical properties as acceptors in conjugate addition reactions, [2+2] and [3+2] cycloaddition reactions are discussed.
Biotin-Avidin-Mediated Capture of Microspheres on Polymer Fibers
Authors: Ahrens Lucas , Vonwil Daniel , Arya Neha , Forget Aurelien , Shastri V. Prasad
Published: May 2019

Systems for efficient and selective capture of micro-scale objects and structures have application in many areas and are of particular relevance for selective isolation of mammalian cells. Systems for the latter should also not interfere with the biology of the cells. This study demonstrates the capture of microspheres through orthogonal coupling using biotin (ligand) and (strept)avidin (receptor). Fibrous poly(ethylene terephthalate) (PET) meshes were hydrolyzed under controlled alkaline conditions to obtain activated surfaces with COOH groups allowing for the functionalization of the PET with biotin of various spacer length. The system capture efficiency was optimized by varying the length of spacer presenting the biotin against streptavidin. In a proof of concept experiment, avidin-functionalized microspheres were used as surrogates for cells, and their capture under dynamic conditions including virous mixing and high-flow rate perfusion is demonstrated. Functionalization of PET meshes with biotin conjugated to longest spacer yielded the most efficient capture of microspheres. These preliminary results lay the foundation for the development of biosystems for capture of specific cells under physiologically relevant conditions, using biorthogonal avidin-biotin interactions.
Thermal Conductivity of Metal-Coated Tri-Walled Carbon Nanotubes in the Presence of Vacancies-Molecular Dynamics Simulations
Authors: Dhumal Ravindra Sunil , Bommidi Dinesh , Salehinia Iman
Published: May 2019

Variation in the thermal conductivity of a metal-coated tri-walled carbon nanotube (3WCNT), in the presence of vacancies, was studied using non-equilibrium molecular dynamics simulations. A Two-Temperature model was used to account for electronic contribution to heat transfer. For 3WCNT with 0.5% and 1% random vacancies, there was 76%, and 86% decrease in the thermal conductivity, respectively. In that order, an overall ~66% and ~140% increase in the thermal conductivity was recorded when 3 nm thick coating of metal (nickel) was deposited around the defective models. We have also explored the effects of tube specific and random vacancies on thermal conductivity of the 3WCNT. The changes in thermal conductivity have also been justified by the changes in vibrational density of states of the 3WCNT and the individual tubes. The results obtained can prove to be useful for countering the detrimental effects of vacancies in carbon nanotubes.
Combined Influence of Meso- and Macroporosity of Soft-Hard Templated Carbon Electrodes on the Performance of Li-O2 Cells with Different Configurations
Authors: Olivares-Marín Mara , Aklalouch Mohamed , Tonti Dino
Published: May 2019

Li-O2 batteries can offer large discharge capacities, but this depends on the morphology of the discharged Li2O2, which in turn is strongly affected by the nanostructured carbon used as support in the air cathode. However, the relation with the textural parameters is complex. To investigate the combined effect of channels of different sizes, meso-macroporous carbons with similar mesopore volume but different pore size distribution were prepared from the polymerization of resorcinol-formaldehyde (RF) in the presence of surfactants and micro-CaCO3 particles. The carbon materials were used as active materials of air cathodes flooded by ionic liquid-based electrolytes in Li-O2 cells with two different configurations, one with a static electrolyte and the other with a stirred electrolyte, which favor a film-like and large particle deposition, respectively. The presence of large pores enhances the discharge capacity with both mechanisms. Conversely, with respect to the reversible capacity, the trend depends on the cell configuration, with macroporosity favoring better performance with static, but poorer with stirred electrolytes. However, all mesoporous carbons demonstrated larger reversible capacity than a purely macroporous electrode made of carbon black. These results indicate that in addition to pore volume, a proper arrangement of large and small pores is important for discharge capacity, while an extended interface can enhance reversibility in Li–O2 battery cathodes.
Natural Antioxidant Anthocyanins—A Hidden Therapeutic Candidate in Metabolic Disorders with Major Focus in Neurodegeneration
Authors: Ullah Rahat , Khan Mehtab , Shah Shahid Ali , Saeed Kamran , Kim Myeong Ok
Published: May 2019

All over the world, metabolic syndrome constitutes severe health problems. Multiple factors have been reported in the pathogenesis of metabolic syndrome. Metabolic disorders result in reactive oxygen species (ROS) induced oxidative stress, playing a vital role in the development and pathogenesis of major health issues, including neurological disorders Alzheimer’s disease (AD) Parkinson’s disease (PD). Considerable increasing evidence indicates the substantial contribution of ROS-induced oxidative stress in neurodegenerative diseases. An imbalanced metabolism results in a defective antioxidant defense system, free radicals causing inflammation, cellular apoptosis, and tissue damage. Due to the annual increase in financial and social burdens, in addition to the adverse effects associated with available synthetic agents, treatment diversion from synthetic to natural approaches has occurred. Antioxidants are now being considered as convincing therapeutic agents against various neurodegenerative disorders. Therefore, medicinal herbs and fruits currently receive substantially more attention as commercial sources of antioxidants. In this review, we argue that ROS-targeted therapeutic interventions with naturally occurring antioxidant flavonoid, anthocyanin, and anthocyanin-loaded nanoparticles might be the ultimate treatment against devastating illnesses. Furthermore, we elucidate the hidden potential of the neuroprotective role of anthocyanins and anthocyanin-loaded nanoparticles in AD and PD neuropathies, which lack sufficient attention compared with other polyphenols, despite their strong antioxidant potential. Moreover, we address the need for future research studies of native anthocyanins and nano-based-anthocyanins, which will be helpful in developing anthocyanin treatments as therapeutic mitochondrial antioxidant drug-like regimens to delay or prevent the progression of neurodegenerative diseases, such as AD and PD.
The Potential of Carnosine in Brain-Related Disorders: A Comprehensive Review of Current Evidence
Authors: Schön Martin , Mousa Aya , Berk Michael , Chia Wern L. , Ukropec Jozef , Majid Arshad , Ukropcová Barbara , de Courten Barbora
Published: May 2019

Neurological, neurodegenerative, and psychiatric disorders represent a serious burden because of their increasing prevalence, risk of disability, and the lack of effective causal/disease-modifying treatments. There is a growing body of evidence indicating potentially favourable effects of carnosine, which is an over-the-counter food supplement, in peripheral tissues. Although most studies to date have focused on the role of carnosine in metabolic and cardiovascular disorders, the physiological presence of this di-peptide and its analogues in the brain together with their ability to cross the blood-brain barrier as well as evidence from in vitro, animal, and human studies suggest carnosine as a promising therapeutic target in brain disorders. In this review, we aim to provide a comprehensive overview of the role of carnosine in neurological, neurodevelopmental, neurodegenerative, and psychiatric disorders, summarizing current evidence from cell, animal, and human cross-sectional, longitudinal studies, and randomized controlled trials.