bluuebunny/crossref_metadata_2025 huggingface dataset:
Comprehensive Perspectives for Erectile Dysfunction Pharmacotherapy:
From Mechanism to Application
Authors: Zhang Haibao , Zhu Guodong , Ren Haomin , Song Wenbin , Yang Zhishang
Published: June 2022

In recent years, the incidence of erectile dysfunction (ED) has continued to rise worldwide. Since pharmacotherapy is still the most common and effective method for the treatment of ED at present, many methods and drugs have been designed or developed for the treatment of ED. Oral phosphodiesterase-5 inhibitors and androgen supplement therapy are currently the common therapeutics for ED; however, some patients have poor response to these drugs because of the multiple pathogenic mechanisms of ED. Researchers are trying to find other treatment ways. On the one hand, many new strategies and concepts such as targeted therapy are also integrated into clinical or preclinical research; on the other hand, some combined therapies which have synergistic effects with reduced dose of single drug and less adverse effects are also developed. This review article summarized the efficacy of the latest first-line, second-line drugs and adjuvant therapies for the treatment of ED, as well as the application of comprehensive treatments, which will help doctors to not only deeply understand the mechanism of ED but select the suitable therapeutics for those patients.
Analysis of Pharmacological Activities and Mechanisms of Essential Oil in Leaves ofC. grandis‘Tomentosa’ by GC-MS/MS and Network Pharmacology
Authors: You Jie-Shu , He Sheng-Cai , Chen Liang , Guo Zhen-Hui , Gao Fei , Zhang Min-Yue , Dan Liu , Chen Wei
Published: June 2022

Background:

Citrus grandis ‘Tomentosa,’ a fruit epicarp of C. grandis ‘Tomentosa’ or C. grandis (L.) Osbeck is widely used in health food and medicine. Based on our survey results, there are also rich essential oils with bioactivities in leaves, but the chemical compounds in this part and relevant pharmacological activities have never been studied systematically. Therefore, this study was to preliminarily decipher the pharmacological activities and mechanisms of the essential oil in leaves of C. grandis ‘Tomentosa’ by an integrated network pharmacology approach.

Methods:

Essential oil compositions from leaves of C. grandis ‘Tomentosa’ were identified using GC-MS/MS. And then, the targets of these oil compositions were predicted and screened from TCMSP, SwissTargetPrediction, STITCH and SEA databases. STRING database was used to construct the protein-protein interaction networks, and the eligible protein targets were input into WebGestalt 2019 to carry out GO enrichment and KEGG pathway enrichment analysis. Based on the potential targets, disease enrichment information was obtained by TTD databases. Cytoscape software was used to construct the component-target-disease network diagrams.

Results:

Finally, 61 essential oil chemical components were identified by GC-MS/MS, which correspond to 679 potential targets. Biological function analysis showed 12, 19, and 12 GO entries related to biological processes, cell components and molecular functions, respectively. 43 KEGG pathways were identified, of which the most significant categories were terpenoid backbone biosynthesis, TNF signaling pathway and leishmaniasis. The component-target-disease network diagram revealed that the essential oil compositions in leaves of C. grandis ‘Tomentosa’ could treat tumors, immune diseases, neurodegenerative diseases and respiratory diseases, which were highly related to CHRM1, PTGS2, CASP3, MAP2K1 and CDC25B.

Conclusion:

This study may provide new insight into C. grandis ‘Tomentosa’ or C. grandis (L.) Osbeck and may provide useful information for future utilization and development.
Exosomes as Targeted Delivery Drug System: Advances in Exosome
Loading, Surface Functionalization and Potential for Clinical Application
Authors: Guo Zun Y. , Tang Yue , Cheng Yi C.
Published: June 2022

Exosomes are subtypes of vesicles secreted by almost all cells and can play an important role
in intercellular communication. They contain various proteins, lipids, nucleic acids and other natural
substances from their metrocytes. Exosomes are expected to be a new generation of drug delivery systems
due to their low immunogenicity, high potential to transfer bioactive substances and biocompatibility.
However, exosomes themselves are not highly targeted, it is necessary to develop new surface
modification techniques and targeted drug delivery strategies, which are the focus of drug delivery research.
In this review, we introduced the biogenesis of exosomes and their role in intercellular communication.
We listed various advanced exosome drug-loading techniques. Emphatically, we summarized
different exosome surface modification techniques and targeted drug delivery strategies. In addition, we
discussed the application of exosomes in vaccines and briefly introduced milk exosomes. Finally, we
clarified the clinical application prospects and shortcomings of exosomes.
Heme Oxygenase-1 may Mediate Early Inflammatory Response of Intracerebral
Hemorrhage through Toll-like Receptor 4 Signaling Pathway
Authors: Qi Jiping , Song Yuejia , Li Ke , Zhang Zhen , Liu Qi , Wang Yu
Published: June 2022

Objective:

The aim of this study was to investigate whether heme oxygenase-1 (HO-1)
promotes an early neuroinflammatory response after intracerebral hemorrhage (ICH) by regulating
the toll-like receptor 4 (TLR4) signaling pathway.

Methods:

We used a stereotaxic instrument to induce a mouse model of ICH through collagenase.
We divided the participants into a control group, an ICH group, and an ICH and zinc protoporphyrin
IX (ZnPP) group. The temporal expression pattern and cell localization of HO-1 and TLR4 after the
ICH were detected by immunofluorescence and western blot; after the expression of HO-1 was inhibited,
the expression levels of the TLR4 protein, the downstream molecule myeloid differentiation
factor 88 (MyD88), the Toll and interleukin-1 receptor (TIR) -domain-containing adapter-inducing
interferon-β (TRIF) and the inflammatory factors were measured by western blotting.

Results:

Immunofluorescence showed that HO-1 and TLR4 had similar temporal expression patterns
and cellular localization after ICH, and we found that inhibiting HO-1 reduces the expression
of TLR4 protein pathways, including TLR4, MyD88, TRIF, and related inflammatory factors, by
studying the inhibitor ZnPP.

Conclusion:

These results indicate that HO-1 may promote early neuroinflammation after ICH
through the TLR4/MyD88/TRIF signaling pathway.
An In-Silico Approach to Identify Therapeutic Target and Markers Associated with Diabetic Nephropathy
Authors: Rai Bhuvnesh , Maurya Pramod Kumar , Srivastava Medha , Mishra Prabhakar , Asif Mehar Hasan , Tiwari Swasti
Published: June 2022

Background:

Renal disease in T2DM could arise independently of hyperglycemia, aka
non diabetic kidney disease. Its prevalence ranges from 33% to 72.5% among T2DM patients.
Specific molecular signatures that distinguish Diabetic Nephropathy from NDKD (FSGS) in
T2DM might provide new targets for CKD management.

Methods:

Five original GEO microarray DN and FSGS datasets were evaluated (GSE111154,
GSE96804, GSE125779, GSE129973 and GSE121233). Each of the three groups (DN, FSGS, and
Controls) had equal renal transcriptome data (n=32) included in the analysis to eliminate bias. The
DEGs were identified using TAC4.0. Pathway analysis was performed on the discovered genes
aligned to official gene symbols using Reactome, followed by functional gene enrichment analysis
using Funrich, Enrichr. STRING and Network analyst investigated PPI, followed by Webgestalt's
pathway erichment. Finally, using the Targetscan 7.0 and DIANA tools, filtered differential microRNAs
downregulated in DN were evaluated for target identification.

Result:

Between the three groups, DN, FSGS, and Control, a total of 194 DEGs with foldchange,>
2&<-2 and P-value0.01 were found in the renal transcriptome. In comparison to control,
45 genes were elevated, particularly in DN, whereas 43 were upregulated specifically in FSGS. DN
datasets were compared to FSGS in a separate analysis. FABP4, EBF1, ADIRF, and ART4 were
shown to be among the substantially up-regulated genes unique to DN in both analyses. The transcriptional
regulation of white adipocytes was discovered by pathway analysis.

Conclusion:

The molecular markers revealed might be employed as specific targets in the aetiology
of DN, as well as in T2DM patients' therapeutic care.
Docetaxel-induced Flagellate Erythema - Case Report and Brief Review
Authors: Asma Jerbi , Sarrah Kastalli , Ons Charfi , Riadh Dhaghfous , Sihem El Aidli
Published: June 2022

Introduction:

Flagellate erythema is a distinctive morphologic reaction pattern, recognized by whiplash-like
pruritic erythematous eruption. Usually encountered in patients receiving bleomycin. Only one
case of docetaxel induced flagellate erythema was reported in the literature.

Case report:

Here in, we report a rare case of docetaxel induced flagellate erythema in a 53 years old woman with no particular medical history treated with docetaxel for metastatic adenocarcinoma of her right breast. Seven days after the third course, she developed multiple lineal and parallel pruritic erythematous streaks mainly on her chest and abdomen. The cutaneous erythema disappeared gradually over 10 days leaving hyper-pigmented post inflammatory linear scars lasting two
weeks. The same reaction reappeared after the fourth and the fifth docetaxel course.

Conclusion:

Flagellate erythema has been reported as an adverse drug reaction secondary to several
antineoplastic molecules including docetaxel. Further studies are needed to discover its
underlying mechanisms in order to figure out better treatment plans and prevention.
Hepatoprotective Effect of Myricetin following Lipopolysaccharide/DGalactosamine:
Involvement of Autophagy and Sirtuin 1
Authors: Roghani Mehrdad , Rostami Amir , Baluchnejadmojarad Tourandokht
Published: June 2022

Background:

Acute liver injury (ALI) is a critical and fatal disorder associated with excessive
oxidative stress and inflammation, ultimately leading to the death of hepatocytes. Myricetin is a
bioflavonoid in some berries, including blueberries and strawberries, with anti-inflammatory, antioxidant
and anti-apoptotic properties.

Objective:

In the current research, the hepatoprotective potential of myricetin was studied in the
LPS/D-GalN model of ALI in C57BL/6 mice.

Methods:

For inducing liver injury, D-GalN (400 mg/kg) and LPS (50 g/kg) were injected via intraperitoneal
route and myricetin was orally administered (25 or 100 mg/kg/day) for two days before inducing
injury. Functional indices of liver dysfunction along with hepatic apoptotic, autophagic, oxidative
stress and inflammatory factors were measured.

Results:

Myricetin (100 mg/kg) reduced the fatality rate of animals and pathological liver changes and
suitably lowered serum levels of total bilirubin, 8-OH-dG, ALT, AST and ALP in addition to decreasing
apoptotic, oxidative and inflammatory factors, NOX, NLRP3, caspase 3, MPO and enhancing
some antioxidants. Besides, myricetin improved the hepatic level and activity of sirtuin 1 and reversed
inappropriate alterations of autophagic parameters, including LC3 II, Beclin 1, and P62. The beneficial
effects of myricetin were attenuated after co-treatment with the autophagy inhibitor 3-
methyladenine.

Conclusion:

This study indicates the hepatoprotective potential of myricetin that can be ascribed to its
down-regulation of oxidative, apoptotic, and inflammatory factors and upregulation of antioxidants
besides its partial regulation of sirtuin 1 and autophagic pathway.
Psychometric Properties of Turkish Version of Hypoglycemia Attitudes and Behavior Scale
Authors: İNKAYA Bahar , BULANTEKİN DÜZALAN Özlem
Published: June 2022

Aim: The aim of the study was to assess the reliability and validity of the Hypoglycemia Attitudes and Behavior Scale (HABS) for the Turkish population. Method: The study was conducted with 153 individuals with Type 2 diabetes mellitus who used insulin. In evaluating data, content validity index, Cronbach α, test-retest testing, item total score correlation, explanatory and confirmatory factor analysis and concordance statistics were used. Results: Cronbach alpha values for the subscales were determined as 0.71 for avoidance, 0.72 for confidence, and 0.85 for anxiety. The results of confirmatory factor analysis showed that the factor structure of the adapted scale was in accordance with the three-factor model of the original scale. It was found that the 11-item Hypoglycemia Attitudes and Behavior Scale consisted of three factors: avoidance of hypoglycemia, confidence in hypoglycemia, and anxiety concerning hypoglycemia. Three items in the original scale were removed because their error variances were negative and they did not have significant t values. Conclusion: The results showed that the HABS was a valid and reliable scale instrument for the Turkish population.
The Association between Dizziness and Anxiety: Update to the Treatment
Authors: Choi Seo-Young , Choi Kwang-Dong
Published: June 2022

Anxiety, depression, or other psychiatric symptoms can be the primary cause of dizziness and the secondary complication of dizziness. Regardless of precedence or consequence, dizziness is closely associated with the psychiatric problem. On this ground, this chapter reviews the association between dizziness and anxiety and the treatment for dizziness with psychiatric symptoms.
A Case of Pontine Infarction with Facial Palsy and Vertigo Confused with Ramsay Hunt Syndrome
Authors: Park Jae Seon , Kim Sang Hyun , Lee Jung-Yup , Kim Min-Beom
Published: June 2022

Facial palsy can be caused by central and peripheral causes, and it can also be caused by brain tumors or infarction. A 59-year-old male, who lost his right hearing 13 years ago due to Ramsay Hunt syndrome, visited our hospital with facial palsy and dizziness. Initial brain diffusion-weighted magnetic resonance imaging (MRI) showed no abnormal findings, and recurrent Ramsay Hunt syndrome or a neoplastic lesion in the internal auditory canal was suspected. After hospitalization, the patient was administered high-dose steroids, and the videonystagmography showed direction-changing gaze-induced nystagmus, so a brain MRI reexamination was scheduled. While waiting for MRI, the patient complained of neurological symptoms such as diplopia, and right lower pontine infarction was diagnosed on MRI. The patient was transferred to the neurologic department and was discharged on the 10th day after conservative treatment. During the 1-year follow-up, pontine infarction did not recur, and neurological symptoms such as facial palsy gradually improved.
FASCÍCULO COMPLEMENTARIO III: LISTA PRELIMINAR DE ESPECIES DE PTERIDOFITAS DE LOS ESTADOS DE GUANAJUATO, MICHOACÁN Y QUERÉTARO (MÉXICO)
Authors:   Instituto de Ecología, A.C., Centro regional del Bajío, Díaz-Barriga Horalia , Palacios-Ríos Mónica ,   Instituto de Ecología, A.C., Xalapa
Published: June 2022

En este trabajo se presenta una lista de las pteridofitas que han sido colectadas o citadas para los estados de Guanajuato, Michoacán y Querétaro. Se conoce la existencia de 28 familias, 68 géneros y 300 especies, de las cuales 172 son nuevos registros, al menos para alguno de los estados. La mayoría de las especies se encontraron distribuidas en los bosques de coníferas, bosque mesófilo de montaña, encinares húmedos, bosques de pino-encino, en ambientes de clima húmedo y fresco; en cambio los matorrales xerófilos y los bosques tropicales presentaron en general una riqueza relativamente baja; pocas pteridofitas existen en la vegetación secundaria, en los pastizales y en la vegetación acuática y subacuática.
FASCÍCULO COMPLEMENTARIO V: LISTA DE LA FLORA ESPONTÁNEA DEL JARDÍN BOTÁNICO "EL CHARCO DEL INGENIO", SAN MIGUEL DE ALLENDE, GUANAJUATO (MÉXICO)
Authors:   Independiente, Meagher Walter L.
Published: June 2022

El objeto de este estudio consiste en el inventario de la flora vascular silvestre y en el análisis de algunos aspectos de la vegetación del Jardín Botánico "El Charco del Ingenio" (en lo sucesivo llamado "El Charco"), perteneciente a Cante, A.C. en San Miguel de Allende, Guanajuato, México (en lo sucesivo mencionado como San Miguel), efectuados entre 1991 y 1993. Dentro de cada una de las divisiones (Lycopodiophyta, Polypodiophyta y Magnoliophyta) las plantas se enumeran por orden alfabético de familias, y dentro de ellas con el mismo tipo de secuencia de géneros y especies, Los nombres de las familias van de acuerdo con el Código Internacional de Nomenclatura Botánica, tal como queda establecido en Family Names in Curren Use for Vascular Plants, Bryophytes and Fungi (Hoogland, 1993). El inventario de 270 especies de plantas vasculares se basa en estudios de campo así como en colecciones realizadas en 1991 y 1992 por Charles Glass, y también por Rocío Hernández y Walter L. Meagher en 1993. Las determinaciones, en la mayoría de los casos, se deben al Dr. J. Rzedowski. Los especímenes de respaldo quedaron depositados en el Herbario de Cante, A.C., Calle de Mesones 71, 37700 San Miguel de Allende, Guanajuato, México.
ВПЛИВ ВІТАМІНУ D3, ЗАСТОСОВАНОГО САМОСТІЙНО, В КОМБІНАЦІЇ АБО У ВИГЛЯДІ ФАРМКОМПОЗИЦІЇ З ПРОСТАТОКОРЕКТОРОМ, НА РІВЕНЬ СТАТЕВИХ ГОРМОНІВ ЩУРІВ ІЗ ЕКСПЕРИМЕНТАЛЬНИМ ПРОСТАТИТОМ
Authors: Мараховський Ігор , Величко Наталія , Коренєва Євгенія , Смолєнко Наталія , Чистякова Еліна , Бєлкіна Інна , Бречка Наталія , Кустова Світлана , Бойко Марина , Бондаренко Володимир
Published: June 2022

Вітамін D є необхідним для адекватної продукції стероїдних гормонів та повноцінного сперматогенезу. Його недостатність сприяє розвитку андрогенодефіциту та патоспермії, що може привести до гіпофертильності. Це наводить на думку про можливість використання вітаміну при лікуванні репродуктопатій чоловіків. Однак для цього необхідне експериментальне обґрунтування застосування вітаміну D на моделях, які відображають найбільш розповсюджені варіанти безпліддя. Гіпофертильність чоловіків із простатитом є однією з провідних причин безпліддя.
Мета: вивчення застосування вітаміну D (самостійно або у комплексних схемах) для корекції рівнів статевих гормонів і концентрації фруктози у самців щурів із експериментальним простатитом.
Матеріали та методи. На статевоактивних щурах популяції Вістар із експериментальним простатитом, який викликали шляхом кріотравмування вентральної частини передміхурової залози, проводили корекцію захворювання за допомогою вітаміну D3 в якості монотерапії або разом із простатопротектором Простатиленом (при застосуванні різними шляхами) перорально або у вигляді ректальної фармкомпозиції. Визначали масу сім'яних пухирців та концентрацію в них фруктози та рівень статевих гормонів у сироватці крові.
Результати. При експериментальному холодовому простатиті спостерігається гіпотестостеронемія та зниження співвідношення тестостерон/естрадіол у сироватці крові самців щурів, в сім´яних пухирцях майже в три рази падає концентрація фруктози. Застосування для корекції Простатилену самостійно або у комбінації з вітаміном D3 незалежно від шляхів введення нормалізує андрогенний стан (підвищення вмісту загального тестостерону в сироватці крові) та фруктози в сім’яних пухирцях та не впливає на вміст естрадіолу. Самостійне застосування вітаміну D3 при моделюванні експериментального простатиту не призводить до відновлення секреції чоловічого статевого гормону, але сприяє посиленню реалізації його дії на сім'яні пухирці. Про це свідчить зростання концентрації маси сім'яних пухирців та концентрації фруктози в них.
Висновки. Введення вітаміну D разом із Простатиленом в комплексних схемах лікування простатиту є доцільним, так як має позитивну дію на андрогенну насиченість організму, покращує параметри концентрації фруктози у сім'яних пухирцях, що може сприяти покращенню сперматогенезу та запліднювальних властивостей сім'яної рідини.
An Information System for Symptom Diagnosis and Improvement of Attention Deficit Hyperactivity Disorder: The ADHD360 Project (Preprint)
Authors: Pandria Niki , Petronikolou Vasileia , Lazaridis Aristotelis , Karapiperis Christos , Kouloumpris Eleutherios , Spachos Dimitrios , Fachantidis Anestis , Vasileiou Dimitrios , Vlahavas Ioannis , Bamidis Panagiotis
Published: June 2022

BACKGROUND

Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorders during childhood, however the diagnosis procedure remains challenging as it is non-standardized, multi-parametric and highly dependent on subjective evaluation of the perceived behavior.

OBJECTIVE

To address the challenges of existing procedures for ADHD diagnosis, the ADHD360 project aims to develop a platform for (a) early detection of ADHD by assessing the user’s likelihood of having ADHD characteristics and (b) providing complementary training for ADHD management.

METHODS

A two-phase pilot study was designed to evaluate the ADHD360 platform, including ADHD and non-ADHD participants aged 7-16 years. Machine Learning methods were used to detect discriminative gameplay patterns among the two groups (ADHD, non-ADHD) and estimate a player’s likelihood of having ADHD characteristics.

RESULTS

A preliminary analysis of collected data showed that the trained models achieve high performance in correctly predicting a user’s label (ADHD or non-ADHD) from his gameplay session in the ADHD360 platform.

CONCLUSIONS

ADHD360 is characterized by notable capacity to discriminate player gameplay behavior as either ADHD or non-ADHD. Therefore, the ADHD360 platform could be a valuable complementary tool for early ADHD detection.

CLINICALTRIAL

ClinicalTrials.gov NCT04362982
ChroniSense National Early Warning Score Study (CHESS): a wearable wrist device to measure vital signs in hospitalised patients - a comparison study (Preprint)
Authors: Van Velthoven Michelle Helena , Oke Jason , Kardos Attila
Published: June 2022

BACKGROUND

Wearable devices could be used to continuously monitor vital signs in hospitalised patients but require validation.

OBJECTIVE

This study aims to evaluate the clinical validity of a semi-automated wearable wrist device (ChroniSense Polso™, Yokneam Illit, Israel) to measure vital signs and provide National Early Warning Scores.

METHODS

Vital signs and National Early Warning Scores measured by the wearable device were compared to standard nurse-lead manual measurements. We enrolled adult patients (aged at least 18 years) who required vital sign measurements for at least every 6 hours in a UK Teaching District General Hospital. Wearable device measurements were not used for the clinical decision-making. The primary outcome was the agreement on the individual National Early Warning parameter scores and vital sign measurements: (1) respiratory rate, (2) oxygen saturation, (3) body temperature, (4) systolic blood pressure and (5) heart rate. Secondary outcomes were the agreement on the total National Early Warning Score, the incidence of adverse events, and user-acceptance. To compare the wearable device measurements with the standard measurements, we analysed vital sign measurements by limits of agreement (Bland-Altman analysis) and undertook kappa agreement analyses for National Early Warning Scores. A user experience survey was conducted with questions on comfort of the wrist device, safety, preference, and use.

RESULTS

We included 132 participants in the study with a mean age of 62 years; the majority were men (102, 77.3%). The highest weighted kappas were found for heart rate (0.69 [0.57 to 0.81] for all 385 measurements) and systolic blood pressure (0.39 [0.30 to 0.47] for all 339 measurements). Weighted kappas were low for respiration rate (0.03 [-0.001 to 0.05] for all 445 measurements), temperature (-0.00 [0.00 to 0.00] for all 231 measurements) and oxygen saturation (-0.11 [-0.20 to -0.02] for all 187 measurements). Weighted kappa using Cicchetti-Allison weights showed a kappa of 0.20 (0.03 to 0.38) when using all 56 total National Early Warning Scores scores. The user acceptance survey found that about half of participants found it comfortable to wear the device and liked the look of it. Most said they would wear the device during a next hospital visit and would recommend it to others.

CONCLUSIONS

This study shows promising use of a wearable device to measure vital signs in a hospital setting. Agreement between the standard measurements and wearable were acceptable for systolic blood pressure and heart rate but need to be improved for respiration rate, temperature, and oxygen saturation. Future work needs to improve the clinical validity of wearable devices and larger studies are required that assess clinical outcomes and cost-effectiveness of wearable devices for vital sign measurement.

INTERNATIONAL REGISTERED REPORT

RR2-http://dx.doi.org/10.1136/bmjopen-2018-028219
Artificial Intelligence Applications in Health Care Practice: A Scoping Review (Preprint)
Authors: Sharma Malvika , Savage Carl , Nair Monika , Larsson Ingrid , Svedberg Petra , Nygren Jens M
Published: June 2022

BACKGROUND

Artificial Intelligence (AI) is often heralded as a potential disruptor that will transform the way we do medicine. The amount of data collected and available in health care, coupled with advances in computational power, have contributed to advances in AI and an exponential growth of publications. However, the development of AI applications does not guarantee their adoption into routine practice. There is a risk that despite the resources invested, benefits for patients, staff and society will not be realized if AI implementation is not better understood.

OBJECTIVE

The aim of this study was to explore how the implementation of AI in healthcare practice has been described and researched in the literature by answering three questions: 1. What are the characteristics of research on implementation of AI in practice? 2. What types and applications of AI systems are described? 3. What characteristics of the implementation process for the AI systems are discernable?

METHODS

A scoping review was conducted of Medline (PubMed), Scopus, Web of Science, CINAHL, and PsychInfo databases to identify empirical studies of AI implementation in healthcare since 2011 in addition to snowball sampling of selected reference lists. Titles and abstracts were screened and full-text articles using Rayyan.ai software. Data from the included articles was charted and summarized.

RESULTS

Of the 9218 records retrieved, forty-five articles were included. Most articles were published recently, from high-income countries, cover diverse clinical settings and disciplines, and intended for care-providers. AI systems are predominantly intended for clinical care, particularly clinical care pertaining to patient-provider encounters. Most possess no action autonomy, but rather support human decision-making. The focus of most research is on establishing the effectiveness of interventions, or related to technical and computational aspects of AI systems. Focus on the specifics of implementation processes does not yet seem to be a priority in research and the use of frameworks to guide implementation is rare.

CONCLUSIONS

Our current empirically knowledge derives from implementations of AI systems with low action autonomy and approaches common to other types of information systems. To develop a specific and empirically-based implementation framework, further research is needed on the more disruptive types of AI systems being implemented into routine care and on aspects unique to AI implementation in health care, such as building trust, addressing transparency issues, developing explainable and interpretable solutions and addressing ethical concerns around privacy and data protection.
Changes in Glycemic Control following utilization of a Spanish-language, Culturally Adapted, Diabetes Program: A Retrospective Study (Preprint)
Authors: Edwards Caitlyn , Orellana Elisa , Rawlings Kelly , Rodriguez-Pla Mirta , Venkatesan Aarathi
Published: June 2022

BACKGROUND

Several barriers to diabetes treatment and care exist, particularly in underserved medical communities.

OBJECTIVE

To address these barriers, this study aimed to evaluate a novel, culturally adapted, Spanish-language mHealth diabetes program on glycemic control (hemoglobin A1c [HbA1c]).

METHODS

Professional Spanish translators, linguists, and providers localized the entirety of the Vida Health Diabetes Management Program to a culturally relevant Spanish-language Program. The Spanish-language Vida Health Diabetes Management Program was utilized among 182 (females = 119) Spanish-speaking adults with diabetes. This app-based Program provided access to culturally adapted educational content on diabetes self-management, one-on-one remote counseling and coaching sessions, and on-demand in-app messaging with bilingual (Spanish and English) certified Health Coaches, Registered Dietitian Nutritionists, and Certified Diabetes Care and Education Specialists. HbA1c was the primary outcome measure, and a paired t-test was used to evaluate changes in HbA1c before and after Program utilization. To determine the relationship between Program engagement and changes in glycemic control a cluster-robust multiple regression analysis was employed.

RESULTS

We observed a significant decrease in HbA1c of -1.23 points between baseline (mean: 9.65, SD: 1.56) and follow-up (mean: 8.42, SD: 1.44; P<0.001). Additionally, we observed a greater decrease in HbA1c among participants with high program engagement (change high: -1.59, SD: 1.97; change low: -0.84, SD: 1.64, P <0.001).

CONCLUSIONS

This work highlights clinically as well as statistically significant improvements in glycemic control among Spanish-preference adults enrolled in the Vida Health Spanish Diabetes Management Program. Greater improvements in glycemic control were observed among participants with higher program engagement. These results provide needed support that digital health interventions can support meaningful improvements in glycemic control in a medically underserved community.

CLINICALTRIAL
Effect of Emotional Intelligence to Innovative Work Behavior of Employees Mediated with Tacit Knowledge Sharing in Education Department of Aceh
Authors: Oyadiwa Riandy
Published: June 2022

The purpose of research was to find out the effect of Emotional Intelligence (EI) to Innovative Work Behavior (IWB), and the mediating effect of Tacit Knowledge Sharing (TKS) to Emotional Intelligence (EI) and Innovative Work Behavior (IWB) of employee of the Education Department of Aceh. Using data from 100 employees from the Education Department of Aceh. Sampling was purposefully chosen within each level of office management. The independent variable in this research was Emotional Intelligence, while the dependent variable was Innovative Work Behavior and the mediating variable was Tacit Knowledge Sharing. The method approach is a quantitative method with data collection from questionnaires. The data is analyzed with SPSS program and further analyze with Path analysis method that had been tested for its instrument before validity test and reliability test. The finding of research showed that Emotional Intelligence is positively related to innovative work behavior. Emotional intelligence is positively related to tacit knowledge sharing, tacit knowledge sharing is positively related to innovative work behavior and tacit knowledge sharing mediates emotional intelligence and innovative work behavior
Understanding Black Hole Imaging Based on Very Large Baseline Interferometry (VLBI)
Authors: Chen Yufan (Jerry)
Published: June 2022

In 2019, the Event Horizon Telescope made history when it captured the first known image of a blackhole. The black hole, situated in the center of the Messier 87 galaxy, is more than 55 million light-years away from earth, and was only able to be captured using Very Large Baseline Interferometry (VLBI) technology and the computational imaging technologies integrated into the Event Horizon Telescope array (The Event Horizon Telescope Collaboration, 2019). Astronomical image processing and interferometry requires the collection of radio waves using a radio telescope and analyzing that data with software. VLBI collects signals with multiple telescopes simultaneously, and the resulting data can be reduced and analyzed as data collected by a telescope with the diameter equal to the largest distance between the telescopes, thus is capable of producing an image with higher angular resolution and capturing objects further away from earth. However, due to the distance between the VLBI telescopes, algorithms are needed to fill in the hole within the collected data and reduce atmospheric noise and delays in signals (Very Long Baseline Array (VLBA)). We conduct an in depth review of the algorithm and VLBI as a whole in this paper, and hope to use our findings to further push the development of this great technology.
Perceptions of Teachers on the Removal of School Fees: A Study of Selected Secondary Schools of Kapiri Mposhi District
Authors: Kasebusha Nephat , Banda Martin , Mwansa Beatrice
Published: June 2022

The purpose of the study was to explore the teachers’ perceptions on the removal of school fees in the secondary schoolsof Kapiri Mposhi district in Central province. The study was guided by the following research objectives: to find out the teachers’ perceptions on the removal of school fees in the selected secondary schools of Kapiri Mposhi district, to analyse the benefits of removing school fees in the selected secondary schools of Kapiri Mposhi district, to explore views on challenges due to the removal of school fees in the selected secondary schools of Kapiri Mposhi district and to suggest measures on challenges due to the removal of schools fees in the selected secondary schools of Kapiri Mposhi district. The study employed both the qualitative and quantitative research methods to collect, integrate and analyze data. The study utilized descriptive research design. The target population were subject teachers and school heads of departments from the five selected secondary schools. The sample size for the study was 40 respondents. Purposive sampling was used to select heads of departments. The research instruments used in the study were questionnaires and interview guides. Data was collected through questionnaire and interview methods. Content analysis was used to analyse collected data. The study shows that that the removal of school fees in schools lead to an increase in class sizes, lead to an incease of the school overall enrolment, lead to shortages of classrooms and compromise the lead to poor academic performance among learners. The removal of school fees would lead to reduction of learners’ dropouts in secondary schools. contribute to reduction of financial burdens among parents, lead to equal access to education in society, reduce the financial challenges on schools as schools are paid by government at once and the removal of school fees would lead minimize of absenteeism among learners.
R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 8
Authors: Simpson Alex , Ramagopalan Sreeram V
Published: June 2022

In this latest update we highlight the publication of a draft real-world evidence framework by the UK National Institute for Health and Care Excellence, and describe a press release from Germany’s Institute for Quality and Efficiency in HealthCare outlining how real-world evidence submissions are not following their guidelines. We also discuss whether the lack of adherence to guidelines is due to ignorance of these guidelines on the part of manufacturers, the difficulty in achieving best practices or a failure of guidelines to comprehensively describe best practices.
TOWARDS A TRANSDISCIPLINARY APPROACH IN THE STUDY AND CONTROL OF CRIME
Authors: Simović Miodrag , Šikman Mile
Published: June 2022

Starting from the fact that heavy forms of crime have a great impact on the society as a whole, states are expected to administrate an adequate response. An apparent precondition for swift response at the appearance of heavy crimes is to gain an accurate and deep understanding of these phenomena. In this regard, authors point out that an approach based on strict separation and isolation between criminal doctrines in dealing with the subject of its study is considered to be outdated, i.e., multidisciplinarity and interdisciplinarity arise as a necessary approach. The authors suggest that, as knowledge of different sciences is required within the common problem formulation, it is necessary for experts in individual disciplines to work together while retaining their disciplinary approaches and views. This approach is believed to be successful in enabling comprehensive consideration of the problem and leading to its solving. When it comes to heavy forms of crime, it is clear that this type of social problem will not be solved without transdisciplinary cooperation, and there is no dilemma that these criminal phenomena should be viewed and studied with the integration of all knowledge of criminology, criminal – law (material, procedural and executive), as well as forensic science. Overcoming disciplinary restrictions in responding to severe forms of crime through a multidisciplinary and interdisciplinary approaches will lead to the improvement of theoretical and practical principles of responding to severe forms of crime. Authors have analyzed the assertion that problems of contemporary society that are too complex for one discipline, that they require the connection of various sciences and scientific disciplines in the entire process of acquiring knowledge about heavy forms of criminality, on the one hand, and its resistance, on the other.
THE REPRESENTATION OF THE NATO BOMBING OF YUGOSLAVIA IN FOREIGN ARTISTIC AND MASS MEDIA TEXTS: UNJUSTIFIED WAR OR JUSTIFIED INTERVENTION?
Authors: Mihaljinac Nina , Vujošević Anđela
Published: June 2022

In addition to scientific and historical accounts, artistic and media texts also construct stories of significant events, thus constructing ideologically charged narratives of present and past events. These narratives can become official versions of the past that shape collective memory and identity. Unlike history books, which are written with a greater time distance, media and artistic texts directly influence the formation of narratives about current events and therefore the self-confidence and self-understanding of the collective. Based on an interest in the question of how identity is formed in today's Serbia, this article deals with media and artistic texts that speak about one of the most significant events in Serbia’s recent history - the NATO bombing of the Federal Republic of Yugoslavia. Opinions about this event are divided, and the totality of information about the bombing seems unknowable. To establish a more objective approach to this issue, the images of the bombing created by foreign media and artists are analyzed from the point of view of Memory Studies and through theories of arts and media (Assmann, Hartman, Felman, Laub, Kuljić), primarily using content and linguistic discourse analysis (Foucault, Spitzmüller, Warnke). The analysis has shown that most of the analyzed media texts justify the bombing, while all artworks criticize and condemn it. This has led us to the conclusion that that the bombing wasn’t justified, and that media texts on the subject served as political propaganda. In other words, artistic texts have a greater potential for social and political criticism than the media.
SIGNIFICANCE OF GREEN BONDS ON CONTEMPORARY FINANCIAL MARKET
Authors: Stojkovic Dragan , Jovanovic-Kranjec Milena , Lukovic Maja
Published: June 2022

Since the onset of the global financial crisis at the end of 2008 green projects are becoming increasingly important, and green economy is becoming more and more interesting as an area of research for numerous authors. In this regard, the paper will analyze green bonds that represent an integral part of green finances, i.e. a significant instrument of green economy and a useful mean in fighting climate changes. These securities mostly represent non-taxable financial instruments and have high credit rating, which is why they are very attractive to investors. Green bonds attract more and more attention in the largest world economies, i.e. in China and USA as the major emitters of greenhouse gases. However, they also have a notable role on the markets of some other countries, i.e. France, Germany, Norway, Sweden, Denmark, Finland, India, and South Africa. Green bonds can be of a great significance for the Republic of Serbia, as well. The Republic of Serbia has adopted, in the process of joining the European Union in early 2020, a Negotiating position for the Chapter 27, i.e. the chapter related to environment and climate changes.
PHILOSOPHICAL BASIS OF THE INSTITUTIONALIZATION OF KNOWLEDGE MANAGEMENT
Authors: Bodin Milenko
Published: June 2022

This paper is concerned with the phenomenon of knowledge and its institutionalization in the context of society and state. The analysis deals with two paradigms of knowledge, known in history of philosophy as the ancient and the modern one. On this basis, the institutionalization of knowledge is questioned as an inherent part of the conceptualization of knowledge, but at the same time, as the problem of alienation of the concept from the human frame of understanding it. Consequently, the reflection of the need for a new approach to the problem emerged and it is actually formulated in this work as the Humanological Management approach. This philosophical frame enables the Management of the (institutionalization of) knowledge on the socio-humanistic basis. In this context, the concept of knowledge as the most important human resource becomes theoretical, as well as practical framework of the Science for humans.
THE RELEVANCE OF SOCIAL PERFORMANCE DISCLOSURE FOR FINANCIAL PERFORMANCE OF COMPANIES INCLUDED IN BELEXline INDEX
Authors: Pavlović Milica , Denčić-Mihajlov Ksenija , Stanković Jelena
Published: June 2022

In the contemporary conditions of intense dynamics of competition, clearly articulated demands of the community and booming environmental requests, corporate social responsibility (CSR) becomes an imperative strategy for responsible and ethical company management. The primary goal of the research is to identify the relevance of social performance for financial success of the most liquid Serbian companies included in the BELEXline index in the period from 2014 to 2018. The level of social performance disclosure is determined using content analysis and the formulation of the social performance disclosure index. In order to confirm the initial hypotheses, cluster analysis and the non-parametric Mann-Whitney U test are used. The empirical findings of this research indicate that the disclosure of social performance is relevant only at the level of certain financial indicators, given that the non-financial reporting of the companies from the sample is at a low level. With changing business conditions, higher requirements for CSR, and increasingly demanding regulations on non-financial reporting, this study provides information on the relationship between the social indicators and the financial performance that are important both in terms of defining sustainability strategies at the company level and from the point of view of the capital market, regulatory bodies and the academia.
Telepsicología para la adherencia al tratamiento en pacientes con diabetes mellitus tipo 2: una revisión sistemática
Authors: Pérez Ortiz Alejandro , Becerra Gálvez Ana Leticia , Mancilla Díaz Juan Manuel
Published: June 2022

Objetivos: el artículo tiene dos objetivos, 1) reunir los estudios controlados y no controlados que den evidencia de la eficacia de la Telepsicología sobre índices y conductas de adherencia terapéutica: dieta, actividad física, consumo de medicamentos, monitoreo de glucosa capilar, cuidado del pie y HbA1C; en pacientes con diabetes mellitus tipo 2; 2) analizar las características metodológicas de los estudios.   Diseño metodológico:considerando los criterios PRISMA y la estrategia de búsqueda PIT, se consultaron seis bases de datos: Pubmed, OVID (PsycINFO y PsycArticles), Scopus, CINAHL y Web ofScience.   Resultados:se identificaron un total de 1,547 artículos, pero sólo cinco, ensayos controlados aleatorizados, cumplieron los criterios de inclusión. Las conductas e índices de adherencia terapéutica evaluadas fueron: HbA1C (n =3), actividad física (n = 2), consumo de medicamentos (n =1), monitoreo de glucosa capilar (n =1) y dieta (n =1). En dos estudios, la Telepsicología de tipo asincrónica (i.e. mediante páginas web y apps) mejoró la HbA1C, consumo de medicamentos, monitoreo de glucosa capilar y la dieta; los resultados en la actividad física difieren.   Limitaciones de la investigación:dado que sólo dos estudios describieron información sobre el tamaño del efecto y su intervalo de confianza, no es viable realizar un metaanálisis.   Hallazgos:la Telepsicología basada en la terapia cognitivo-conductual de tipo asincrónica muestra resultados alentadores para mejorar el control glucémico y conductas de adherencia terapéutica en personas con diabetes mellitus. Las investigaciones identificadas se realizaron en Estados Unidos, Europa y Oceanía.
Towards the reflective science communication practitioner
Authors: Roedema Tessa , Rerimassie Virgil , Broerse J. E. W. , Kupper J. F. H.
Published: June 2022

The practice of science communication is fundamentally changing. This requires science communication practitioners to continuously adapt their practice to an ever-changing ecosystem and highlights the importance of reflective practice for science communication. In this study, we supported 21 science communication practitioners in developing a reflective practice. Our study shows that reflective practice enabled practitioners in becoming aware of their own stance towards science or assumptions regarding audiences (single-loop learning), underlying and sometimes conflicting values or worldviews present in science communication situations (double-loop learning), and facilitated practitioners to adapt their practice accordingly. Triple-loop learning, allowing practitioners to fundamentally rethink and transform their mode of science communication, was less observed. We argue that reflective practice contributes to opening-up public conversations on science — including a conversation on underlying values, worldviews, and emotions, next to communicating scientific facts.