bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk of Adverse Financial Events in Patients With Cancer: Evidence From a Novel Linkage Between Cancer Registry and Credit Records
Authors: Shankaran Veena , Li Li , Fedorenko Catherine , Sanchez Hayley , Du Yuxian , Khor Sara , Kreizenbeck Karma , Ramsey Scott
Published: January 2022

PURPOSE

Although financial toxicity is a growing cancer survivorship issue, no studies have used credit data to estimate the relative risk of financial hardship in patients with cancer versus individuals without cancer. We conducted a population-based retrospective matched cohort study using credit reports to investigate the impact of a cancer diagnosis on the risk of adverse financial events (AFEs).

METHODS

Western Washington SEER cancer registry (cases) and voter registry (controls) records from 2013 to 2018 were linked to quarterly credit records from TransUnion. Controls were age-, sex-, and zip code–matched to cancer cases and assigned an index date corresponding to the case's diagnosis date. Cases and controls experiencing past-due credit card payments and any of the following AFEs at 24 months from diagnosis or index were compared, using two-sample z tests: third-party collections, charge-offs, tax liens, delinquent mortgage payments, foreclosures, and repossessions. Multivariate logistic regression models were used to evaluate the association of cancer diagnosis with AFEs and past-due credit payments.

RESULTS

A total of 190,722 individuals (63,574 cases and 127,148 controls, mean age 66 years) were included. AFEs (4.3% v 2.4%, P < .0001) and past-due credit payments (2.6% v 1.9%, P < .0001) were more common in cases than in controls. After adjusting for age, sex, average baseline credit line, area deprivation index, and index/diagnosis year, patients with cancer had a higher risk of AFEs (odds ratio 1.71; 95% CI, 1.61 to 1.81; P < .0001) and past-due credit payments (odds ratio 1.28; 95% CI, 1.19 to 1.37; P < .0001) than controls.

CONCLUSION

Patients with cancer were at significantly increased risk of experiencing AFEs and past-due credit card payments relative to controls. Studies are needed to investigate the impact of these events on treatment decisions, quality of life, and clinical outcomes.
Diet- and Lifestyle‐Based Prediction Models to Estimate Cancer Recurrence and Death in Patients With Stage III Colon Cancer (CALGB 89803/Alliance)
Authors: Cheng En , Ou Fang-Shu , Ma Chao , Spiegelman Donna , Zhang Sui , Zhou Xin , Bainter Tiffany M. , Saltz Leonard B. , Niedzwiecki Donna , Mayer Robert J. , Whittom Renaud , Hantel Alexander , Benson Al , Atienza Daniel , Messino Michael , Kindler Hedy , Giovannucci Edward L. , Van Blarigan Erin L. , Brown Justin C. , Ng Kimmie , Gross Cary P. , Meyerhardt Jeffrey A. , Fuchs Charles S.
Published: January 2022

PURPOSE

Current tools in predicting survival outcomes for patients with colon cancer predominantly rely on clinical and pathologic characteristics, but increasing evidence suggests that diet and lifestyle habits are associated with patient outcomes and should be considered to enhance model accuracy.

METHODS

Using an adjuvant chemotherapy trial for stage III colon cancer (CALGB 89803), we developed prediction models of disease-free survival (DFS) and overall survival by additionally incorporating self-reported nine diet and lifestyle factors. Both models were assessed by multivariable Cox proportional hazards regression and externally validated using another trial for stage III colon cancer (CALGB/SWOG 80702), and visual nomograms of prediction models were constructed accordingly. We also proposed three hypothetical scenarios for patients with (1) good-risk, (2) average-risk, and (3) poor-risk clinical and pathologic features, and estimated their predictive survival by considering clinical and pathologic features with or without adding self-reported diet and lifestyle factors.

RESULTS

Among 1,024 patients (median age 60.0 years, 43.8% female), we observed 394 DFS events and 311 deaths after median follow-up of 7.3 years. Adding self-reported diet and lifestyle factors to clinical and pathologic characteristics meaningfully improved performance of prediction models (c-index from 0.64 [95% CI, 0.62 to 0.67] to 0.69 [95% CI, 0.67 to 0.72] for DFS, and from 0.67 [95% CI, 0.64 to 0.70] to 0.71 [95% CI, 0.69 to 0.75] for overall survival). External validation also indicated good performance of discrimination and calibration. Adding most self-reported favorable diet and lifestyle exposures to multivariate modeling improved 5-year DFS of all patients and by 6.3% for good-risk, 21.4% for average-risk, and 42.6% for poor-risk clinical and pathologic features.

CONCLUSION

Diet and lifestyle factors further inform current recurrence and survival prediction models for patients with stage III colon cancer.
Treatment Exposure and Discontinuation in the PALbociclib CoLlaborative Adjuvant Study of Palbociclib With Adjuvant Endocrine Therapy for Hormone Receptor–Positive/Human Epidermal Growth Factor Receptor 2–Negative Early Breast Cancer (PALLAS/AFT-05/ABCSG-42/BIG-14-03)
Authors: Mayer Erica L. , Fesl Christian , Hlauschek Dominik , Garcia-Estevez Laura , Burstein Harold J. , Zdenkowski Nicholas , Wette Viktor , Miller Kathy D. , Balic Marija , Mayer Ingrid A. , Cameron David , Winer Eric P. , Ponce Lorenzo José Juan , Lake Diana , Pristauz-Telsnigg Gunda , Haddad Tufia C. , Shepherd Lois , Iwata Hiroji , Goetz Matthew , Cardoso Fatima , Traina Tiffany A. , Sabanathan Dhanusha , Breitenstein Urs , Ackerl Kerstin , Metzger Filho Otto , Zehetner Karin , Solomon Kadine , El-Abed Sarra , Theall Kathy Puyana , Lu Dongrui Ray , Dueck Amylou , Gnant Michael , DeMichele Angela
Published: January 2022

PURPOSE

The PALLAS study investigated whether the addition of palbociclib, an oral CDK4/6 inhibitor, to adjuvant endocrine therapy (ET) improves invasive disease-free survival (iDFS) in early hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2–) breast cancer. In this analysis, we evaluated palbociclib exposure and discontinuation in PALLAS.

METHODS

Patients with stage II-III HR+, HER2– disease were randomly assigned to 2 years of palbociclib with adjuvant ET versus ET alone. The primary objective was to compare iDFS between arms. Continuous monitoring of toxicity, dose modifications, and early discontinuation was performed. Association of baseline covariates with time to palbociclib reduction and discontinuation was analyzed with multivariable competing risk models. Landmark and inverse probability weighted per-protocol analyses were performed to assess the impact of drug persistence and exposure on iDFS.

RESULTS

Of the 5,743 patient analysis population (2,840 initiating palbociclib), 1,199 (42.2%) stopped palbociclib before 2 years, the majority (772, 27.2%) for adverse effects, most commonly neutropenia and fatigue. Discontinuation of ET did not differ between arms. Discontinuations for non–protocol-defined reasons were greater in the first 3 months of palbociclib, and in the first calendar year of accrual, and declined over time. No significant relationship was seen between longer palbociclib duration or ≥ 70% exposure intensity and improved iDFS. In the weighted per-protocol analysis, no improvement in iDFS was observed in patients receiving palbociclib versus not (hazard ratio 0.89; 95% CI, 0.72 to 1.11).

CONCLUSION

Despite observed rates of discontinuation in PALLAS, analyses suggest that the lack of significant iDFS difference between arms was not directly related to inadequate palbociclib exposure. However, the discontinuation rate illustrates the challenge of introducing novel adjuvant treatments, and the need for interventions to improve persistence with oral cancer therapies.
Building Sustainable Practice Transformation Through Payment Reform Initiatives
Authors: Rocque Gabrielle B. , Dent D'Ambra N. , Caston Nicole E. , Salter Terri , DeMoss Jordan , Bhatia Smita , Miller Harold , Pisu Maria
Published: January 2022

PURPOSE:

Novel value-based payment approaches provide an opportunity to deploy and sustain health care delivery interventions, such as treatment planning documentation. However, limited data are available on implementation costs.

METHODS:

We described key factors affecting the cost of implementing care improvements under value-based payments, using treatment planning and Medicare's Oncology Care Model as examples. We estimated expected costs of implementing treatment plans for years 1 and 2-6 under (1) different staffing models, (2) use of technology, and (3) differences in the patients engaged. We compared costs to the payment amounts under the Oncology Care Model.

RESULTS:

Team-based models where staffing is aligned with skills needed for key tasks (eg, a combination of lay navigator, nurse, and physician) are more financially feasible when compared with using physicians or nurses alone. When existing staff are at or near capacity, hiring new staff focused on practice transformation activities allows adequate time for new initiatives without negative impacts on existing services. Investments in information technology can enhance staff productivity, but initial costs may be high. Interventions may not be financially feasible if implemented for a small patient volume or only for patients insured by a particular payer. Finally, costs may be higher for disadvantaged populations, and equity in care delivery may require higher payments from payers.

CONCLUSION:

Estimating the cost of implementing an intervention in different types of practice settings with various types of patients is essential to ensure that a value-based payment system will adequately support desired improvements in quality of care for all patients.
Approach to the Pediatric Patient: Central Diabetes Insipidus
Authors: Patti Giuseppa , Napoli Flavia , Fava Daniela , Casalini Emilio , Di Iorgi Natascia , Maghnie Mohamad
Published: January 2022

Central diabetes insipidus (CDI) is a complex disorder in which large volumes of dilute urine are excreted due to arginine-vasopressin deficiency, and it is caused by a variety of disorders affecting the hypothalamic-posterior pituitary network. The differential diagnosis is challenging and requires a detailed medical history, physical examination, biochemical approach, imaging studies, and, in some cases, histological confirmation. Magnetic resonance imaging is the gold standard method for evaluating congenital or acquired cerebral and pituitary stalk lesions. Pituitary stalk size at presentation could be normal, but it may change over time, depending on the underlying condition, while other brain areas or organs may become involved during follow-up. Early diagnosis and treatment are crucial to avoid central nervous system damage and germ cell tumor dissemination and to minimize complications of multiple pituitary hormone defects. We provide a practical update on the diagnosis and management of patients with CDI and highlight several pitfalls that may complicate the differential diagnosis of conditions presenting with polyuria and polydipsia. The need for a careful and close follow-up of patients with apparently idiopathic CDI is particularly emphasized because the underlying condition may be recognized over time. The clinical scenario that we outline at the beginning of this article represents the basis for the discussion about how the etiological diagnosis of CDI can be overlooked and demonstrates how a water intake and urine output improvement can be a sign of progressive damage of both hypothalamus and anterior pituitary gland with associated pituitary hormonal deficiencies.
The matrix in focus: new directions in extracellular matrix research from the 2021 ASMB hybrid meeting
Authors: Nerger Bryan A. , Jones Tia M. , Rose Keron W. J. , Barqué Anna , Weinbaum Justin S. , Petrie Ryan J. , Chang Joan , Vanhoutte Davy , LaDuca Kendra , Hubmacher Dirk , Naba Alexandra
Published: January 2022

The extracellular matrix (ECM) is a complex assembly of macromolecules that provides both architectural support and molecular signals to cells and modulate their behaviors. Originally considered a passive mechanical structure, decades of research have since demonstrated how the ECM dynamically regulates a diverse set of cellular processes in development, homeostasis, and disease progression. In September 2021, the American Society for Matrix Biology (ASMB) organized a hybrid scientific meeting, integrating in-person and virtual formats, to discuss the latest developments in ECM research. Here, we highlight exciting scientific advances that emerged from the meeting including (1) the use of model systems for fundamental and translation ECM research, (2) ECM-targeting approaches as therapeutic modalities, (3) cell-ECM interactions, and (4) the ECM as a critical component of tissue engineering strategies. In addition, we discuss how the ASMB incorporated mentoring, career development, and diversity, equity, and inclusion initiatives in both virtual and in-person events. Finally, we reflect on the hybrid scientific conference format and how it will help the ASMB accomplish its mission moving forward.
Intra-osseous migration in calcific rotator cuff tendinopathy- a novel depiction of temporal evolution on multimodality imaging
Authors: Paruthikunnan Samir Mustaffa , Boily Mathieu , Martin Marie-Hélène , Assaf Adel , Jaffer Rehana
Published: January 2022

We present a case of calcific tendinopathy of the rotator cuff with intraosseous migration of the calcification, treated with ultrasound-guided bursal steroid injection and followed up with multiple imaging modalities for a year following the initial presentation. The radiographs, ultrasound, CT, nuclear scintigraphy, and MRI images demonstrate the temporal evolution of the intraosseous migrated calcium and show how this pathology, in its acute phase, can mimic other pathologies like osteoid osteoma. The follow-up imaging also illustrates how the migrated intraosseous focus of calcification took a much longer time to heal compared to its intratendinous counterpart, possibly leading to the protracted course of recovery. This report also highlights a previously undescribed pattern of healing of the intraosseous migrated calcium on multiple imaging modalities.
Case series demonstrating in vivo MR safety of stainless steel (Chinese/Ring) IUDs
Authors: Thomas Shailin , Hindman Nicole
Published: January 2022

Intrauterine devices (IUDs) are one of the most common forms of long-term contraception used by patients around the world. Many studies have been performed over the past few decades demonstrating the safety of many common hormonal and metallic intrauterine devices in Magnetic Resonance (MR) imaging; however, the stainless steel ring IUD (often termed the “Chinese” IUD) is still considered MR Unsafe. This device was used in the 1980s and 1990s in China, where as many as 60 million women in China were using an IUD by 1988, and approximately 90% of those were stainless steel ring IUDs. In a major metropolitan area hospital such as ours with a large immigrant population, we encounter females with this ring IUD several times a year. As this population ages, the need for medical care (and concomitantly, MR imaging) is projected to increase. The purpose of this case review is to examine the imaging and clinical course of patients with stainless-steel ring intrauterine devices who safely received 1.5T Brain MR scans at our institution for clinically necessary diagnostic imaging.
CBCT in dental age estimation: A systematic review and meta analysis
Authors: Merdietio Boedi Rizky , Shepherd Simon , Mânica Scheila , Franco Ademir
Published: January 2022

Objectives:

This study aimed to investigate the reproducibility of dental age estimation methods in cone beam computed tomography (CBCT) and the correlation between dental (DA) and chronological (CA) ages.

Methods:

The scientific literature was searched in six databases (PubMed, Scopus, LILACS, Web of Science, SciELO, and OATD). Only observational studies were selected. Within each study, the outcomes of interest were (I) the quantified reproducibility of the method (κ statistics and Intraclass correlation coefficient); and (II) the correlation (r) between the dental and chronological ages. A random-effect three-level meta-analysis was conducted alongside moderator analysis based on methods, arch (maxillary/mandibular), population, and number of roots.

Results:

From 671 studies, 39 fulfilled the inclusion criteria, with one study reporting two different methods. The methods used in the studies were divided into metric (n = 17), volumetric (n = 20), staging (n = 2), and atlas (n = 1). All studies reported high examiner reproducibility. Group 1 (metric and volumetric) provided a high inverse weighted r ([Formula: see text] = −0.71, CI [-0.79,–0.61]), and Group 2 (staging) provided a medium-weighted r ([Formula: see text] = 0.49, CI [0.44, 0.53]). Moderator analysis on Group one did not show statistically significant differences between methods, tooth position, arch, and number of roots. An exception was detected in the analysis based on population (Southeast Asia, [Formula: see text] = −0.89, CI [-0.94,–0.81]).

Conclusion:

There is high evidence that CBCT methods are reproducible and reliable in dental age estimation. Quantitative metric and volumetric analysis demonstrated better performance in predicting chronological age than staging. Future studies exploring population-specific variability for age estimation with metric and volumetric CBCT analysis may prove beneficial.
Incidence of and Risk Factors for Perioperative Cardiovascular Complications in Spine Surgery
Authors: Chotisukarat Haruthai , Akavipat Phuping , Suchartwatnachai Pathomporn , Sookplung Pimwan , Eiamcharoenwit Jatuporn
Published: January 2022

Background: An increasing number of patients are opting for spine surgery despite the associated risk of cardiovascular complications. The evidence regarding the incidence and risk factors of cardiovascular complications in spine surgery is insufficient. Therefore, we aimed to determine the incidence and risk factors for cardiovascular complications that occur perioperatively in spine surgery.

Methods: This retrospective study included all patients who underwent spine surgery between January 2018 and December 2019 at a single center. Demographic, clinical, and operative data were collected from electronic medical records. The incidence of perioperative cardiac complications was determined. Univariate and multivariate analyses were performed to identify risk factors for the development of perioperative cardiovascular complications in the participants.

Results: Of the 1,002 eligible patients enrolled in the study, six developed cardiac complications. Acute myocardial infarction, cardiac arrest, and congestive heart failure occurred in one, two, and three patients, respectively. Risk factors for cardiovascular complications included scoliosis surgery (relative risk: RR, 18.61; 95% confidence interval (CI): 1.346-257.35) and a history of congestive heart failure (RR, 120.97; 95% CI: 2.12-6898.80).

Conclusion: The incidence of perioperative cardiovascular complications in patients who underwent spine surgery was 0.6%. High-risk patients should be closely monitored optimally managed throughout the perioperative period.
Does the use of mobile applications or mobile health technology improve diet quality in adults? A protocol for a systematic literature review
Authors: Scarry Alan , Rice Jennifer , O' Connor Eibhlís M , Tierney Audrey C
Published: January 2022

Background: Mobile technology has grown at an exceptional rate and is now a huge part of our daily living. This use of mobile technology has opened up new possibilities in treating health, with almost half of the current applications linked to the mHealth sector. In particular, dietary measurement, applications have become very accessible and very popular. As dietary issues have become more prevalent, more mobile and mHealth applications offer various solutions. This systematic review aims to address if the use of such mobile applications or mobile health technology can improve diet quality in adults that interact with them.

Methods: A systematic review of randomised controlled trials (RCTs) and non-randomised controlled trials (NRCTs) will be conducted. The Cumulative Index to Nursing and Allied Health Literature (Cinahl), The American Psychological Association’s (APA Psycinfo), and PubMed will be searched from January 2010 to November 2021. Primary outcomes will include identifying if adults who use mobile applications and health technology improve their diet quality compared to adults who do not use this technology. Study selection will follow the Preferred Reporting Items for Systematic Reviews and MetaAnalyses (PRISMA) guidelines. The methodological appraisal of the studies will be assessed independently by two different reviewers (AS and JR) using the Cochrane Risk-of-Bias Tool for RCTs and the Risk-of Bias In Non-Randomised Studies Tool for NRCTs.

Ethics and dissemination: Ethical approval is not essential for this systematic review. Only data from studies that are publically available from previously published studies will be used. The findings of this systematic review will be submitted for publication in a peer-reviewed journal and presented at relevant conferences. PROSPERO registration: CRD42021240224 (01/03/2021).
Semantic competency as a marker of clinical reasoning performance
Authors: Berge Michael , Soh Michael , Fahlsing Christopher , MacKinnon Rene , Wetstein Berish , Anderson Andrew , Konopasky Abigail , Durning Steven
Published: January 2022

Background: This study sought to explore the relationship between semantic competence (or dyscompetence) displayed during “think-alouds” performed by resident and attending physicians and clinical reasoning performance.

Methods: Internal medicine resident physicians and practicing internists participated in think-alouds performed after watching videos of typical presentations of common diseases in internal medicine. The think-alouds were evaluated for the presence of semantic competence and dyscompetence and these results were correlated with clinical reasoning performance. 

Results: We found that the length of think-aloud was negatively correlated with clinical reasoning performance. Beyond this finding, however, we did not find any other significant correlations between semantic competence or dyscompetence and clinical reasoning performance.

Conclusions: While this study did not produce the previously hypothesized findings of correlation between semantic competence and clinical reasoning performance, we discuss the possible implications and areas of future study regarding the relationship between semantic competency and clinical reasoning performance.
Drone-based electromagnetic survey system for geophysical applications
Authors: Pirttijärvi Markku , Saartenoja Ari , Korkeakangas Pekka
Published: January 2022

Geophysical electromagnetic (EM) methods are used in geological mapping, mineral exploration, groundwater studies and geotechnical investigations. Airborne EM methods have the benefit of avoiding terrain obstacles such as lakes, rivers, swamps, and ravines. Compared to manned aircrafts, drones or unmanned aerial vehicles (UAVs) have benefits of their own. Drone-based surveys are versatile, fast to deploy, economical and ecologically more friendly. Presently, magnetic surveying is the only geophysical method that is routinely conducted with drones. The modest maximum payload limit of drones imposes severe restrictions on the applicability of other methods including EM and radiometric methods, for example. Finnish company, Radai Ltd has been developing Louhi, a novel drone-based frequency-domain EM survey system, in an EU funded Horizon 2020 project NEXT – New Exploration Technologies. The EM system has two operation options – the first uses a large loop on the ground as an EM source and the other uses a small portable EM transmitter loop. Both systems utilize a stand-alone and light-weight three-component EM receiver that can be towed by a drone. This article presents the theoretical background of the EM methods, the solution developed by Radai Ltd, the current version of the EM device, and results from field and flight tests that demonstrate the applicability of the drone-based EM system under development.
Optimal Order Batching in Warehouse Management: A Data-Driven Robust Approach
Authors: Bayram Vedat , Baloch Gohram , Gzara Fatma , Elhedhli Samir
Published: January 2022

Optimizing warehouse processes has direct impact on supply chain responsiveness, timely order fulfillment, and customer satisfaction. In this work, we focus on the picking process in warehouse management and study it from a data perspective. Using historical data from an industrial partner, we introduce, model, and study the robust order batching problem (ROBP) that groups orders into batches to minimize total order processing time accounting for uncertainty caused by system congestion and human behavior. We provide a generalizable, data-driven approach that overcomes warehouse-specific assumptions characterizing most of the work in the literature. We analyze historical data to understand the processes in the warehouse, to predict processing times, and to improve order processing. We introduce the ROBP and develop an efficient learning-based branch-and-price algorithm based on simultaneous column and row generation, embedded with alternative prediction models such as linear regression and random forest that predict processing time of a batch. We conduct extensive computational experiments to test the performance of the proposed approach and to derive managerial insights based on real data. The data-driven prescriptive analytics tool we propose achieves savings of seven to eight minutes per order, which translates into a 14.8% increase in daily picking operations capacity of the warehouse.
Separated by a Common Language: How the Nature of Code Differences Shapes Communication Success and Code Convergence
Authors: Koçak Özgecan , Puranam Phanish
Published: January 2022

Coordinated action within and beween organizations is easier when individuals share communication codes—mappings between stimuli and labels. Because codes are specific to the groups within which they arise as conventions, collaboration across organizational units that have developed their own distinctive codes is often difficult. However, not all code differences are equal in their implications for communication difficulty and the capacity of individuals starting out with different codes to develop a shared code. Using computational models, we develop a theory about the nature of differences in initial communication codes and how they impact convergence on a common code. Our results show that the difficulty of code convergence lies not as much in learning new codes as in unlearning existing ones. The most severe challenges to communication stem from “code clashes” where codes contain different mappings between the same labels and stimuli. Furthermore, clashes that arise when agents have developed their individual codes in different task environments but draw on a common set of labels are likely to be the hardest to recover from, reflecting the perils of being “separated by a common language.”

This paper was accepted by Lamar Pierce, organizations.
The Role of Resources in the Success or Failure of Diverse Teams: Resource Scarcity Activates Negative Performance-Detracting Resource Dynamics in Social Category Diverse Teams
Authors: Yu Siyu , Greer Lindred L.
Published: January 2022

Increasing the social category diversity of work teams is top of mind for many organizations. However, such efforts may not always be sufficiently resourced, given the numerous resource demands facing organizations. In this paper, we offer a novel take on the relationship between social category diversity and team performance, seeking to understand the role resources may play in both altering and explaining the performance dynamics of diverse teams. Specifically, our resource framework explains how the effects of social category diversity on team performance can be explained by intrateam resource cognitions and behaviors and are dependent on team resource availability. We propose that in the face of scarcity in a focal resource (i.e., budget), diverse (but not homogenous) teams generalize this scarcity perception to fear that all resources (i.e., staff, time, etc.) are scarce, prompting performance-detracting power struggles over resources within the team. We find support for our model in three multimethod team-level studies, including two laboratory studies of interacting teams and a field study of work teams in research and development firms. Our resource framework provides a new lens to study the success or failure of diverse teams by illuminating a previously overlooked danger in diverse teams (negative resource cognitions (scarcity spillover bias) and behaviors (intrateam power struggles)), which offers enhanced explanatory power over prior explanations. This resource framework for the study of team diversity also yields insight into how to remove the roadblocks that may occur in diverse teams, highlighting the necessity of resource sufficiency for the success of diverse teams.
A Monotone Approximate Dynamic Programming Approach for the Stochastic Scheduling, Allocation, and Inventory Replenishment Problem: Applications to Drone and Electric Vehicle Battery Swap Stations
Authors: Asadi Amin , Nurre Pinkley Sarah
Published: January 2022

There is a growing interest in using electric vehicles (EVs) and drones for many applications. However, battery-oriented issues, including range anxiety and battery degradation, impede adoption. Battery swap stations are one alternative to reduce these concerns that allow the swap of depleted for full batteries in minutes. We consider the problem of deriving actions at a battery swap station when explicitly considering the uncertain arrival of swap demand, battery degradation, and replacement. We model the operations at a battery swap station using a finite horizon Markov decision process model for the stochastic scheduling, allocation, and inventory replenishment problem (SAIRP), which determines when and how many batteries are charged, discharged, and replaced over time. We present theoretical proofs for the monotonicity of the value function and monotone structure of an optimal policy for special SAIRP cases. Because of the curses of dimensionality, we develop a new monotone approximate dynamic programming (ADP) method, which intelligently initializes a value function approximation using regression. In computational tests, we demonstrate the superior performance of the new regression-based monotone ADP method compared with exact methods and other monotone ADP methods. Furthermore, with the tests, we deduce policy insights for drone swap stations.
Clinical risk and legal risk: their impact on consent
Authors: Finch John
Published: January 2022

John Finch discusses clinical and legal risk and the consequences they have for consent in legal matters concerning clinical practice
Green Synthesis of Ceria Nanoparticles Using Azadirachta Indica Plant Extract: Characterization, Gas Sensing and Antibacterial Studies
Authors: Ahire Satish Arvind , Bachhav Ashwini Ashok , Pawar Thansingh Bhavsing , Patil Arun Vitthal , Shendge Swapnil Sampatrao , Koli Prashant Bhimrao
Published: January 2022

In the present investigation we have fabricated the cerium dioxide (CeO2) nanoparticles by green route. While preparing the cerium dioxide nanoparticles by co-precipitation method, Neem leaf extract mixed into the precursor of cerium. The synthesized nanoparticles of CeO2 were used for the preparation of thick film sensor by using screen printing strategy. The fabricated CeO2 sensor was characterized by XRD, SEM, EDS and TEM techniques. The structural characteristics investigated by x-ray diffraction technique (XRD). XRD confirms the formation of cubic lattice of CeO2 material. The surface, texture, porosity characteristics were investigated from SEM analysis, while chemical composition of the material was analysed by EDS technique. The transmission electron microscopy (TEM) confirms the formation cubic lattice of the cerium dioxide material. The thickness of the films was calculated from mass difference method, the prepared film sensors belong to thick region. The fabricated material CeO2 sensor was applied as gas sensor to sense the gases such as LPG, petrol vapors (PV), toluene vapors (TV) and CO2. The CeO2 sensor showed excellent gas response for LPG and PV, nearly 93.20 % and 78.23 % gas response. The rapid response and recovery of the prepared sensors was observed at the tested gases. CeO2 material also employed for antibacterial study at several pathogenic organism such as pseudomonas, staphylococcus aureus and salmonella typhae. From antibacterial study it was observed that the material is capable of inhibiting the growth of these pathogenic microbes.
Magnetic and Structural Behaviour of Cobalt & Nickel Substituted Calcium W-Type Nanosize Hexaferrites
Authors: C Tolani Smita , G Rewatkar Kishorchandra
Published: January 2022

The available literature and research work on W-type hexaferrites is mainly focused on Co- and Zn-based calcium W-type hexagonal ferrites with a variety of cationic substitutions. The Modifications in the properties of the Calcium W-type ferrite based on Ni2+ as the divalent metal ion, however, is not studied sufficiently in the research literature vailable. In this study, the focus is mainly on the effects of substitution of Ni2+ on the properties of CaCo2W exaferrites. The investigations carried out are mainly XRD, SEM and VSM. The main objective of this research investigation is to study the effect of substitution of Nickel and Cobalt on the structural and magnetic properties of calcium W-type hexaferrite CaCo2-xNixFe16O27 (x=0, 1 and 2). XRD analysis and characterization revealed slight decrease in the values of lattice constants ‘a’ and ‘c’ with increase in concentration ‘x’. The particle size was confirmed from SEM and TEM images. The analysis of VSM for magnetic properties reveals decrease in coercivity and increase in the values of saturation magnetization as concentration increases. The results of measurements made bythe various experimental techniques and the observations were compared to understand the crystalline and magnetic structure of the compounds
Myths about myths? A commentary on Thomas (2020) and the question of jury rape myth acceptance
Authors: Daly Ellen , Smith Olivia , Bows Hannah , Brown Jennifer , Chalmers James , Cowan Sharon , Horvath Miranda , Leverick Fiona , Lovett Jo , Munro Vanessa , Willmott Dominic
Published: January 2022

This commentary responds to claims that research by Cheryl Thomas ‘shows’ no problem with rape myths in English and Welsh juries. We critique the claim on the basis of ambiguous survey design, a false distinction between ‘real’ jurors and other research participants, the conflation of attitudes in relation to abstract versus applied rape myths, and misleading interpretation of the data. Ultimately, we call for a balanced appraisal of individual studies by contextualising them against the wider literature.
High-precision displacement measurement algorithm based on a depth fusion
of grating projection pattern
Authors: Yu Hai , Wan Qiuhua , Lu Xinran , Du Yingcai , Liang Lihui
Published: January 2022

Displacement measurement based on an image recognition algorithm has more advantages in the field of displacement measurement. Due to the uncertainty of image location, the accuracy of the displacement measurement algorithm studied in the previous stage is limited. To improve the accuracy of image-type displacement measurement, a high-precision displacement measurement algorithm based on depth fusion of the grating projection pattern is proposed. First, a line-scan image sensor and parallel light source are placed on both sides of the calibration grating. The marking pattern on the calibration grating is projected onto the image sensor through illumination of the parallel light source to realize the projection imaging. Then, the centroid algorithm is used to calculate the centroid of each line in the collected image, and the mean value of the centroid group is determined. Finally, a linear function is used to fit multiple centroids to calculate the endpoints of the subdivision region, and the subdivision operation is carried out according to a ratio algorithm. To test the performance of the proposed algorithm, a linear displacement measurement device with a 250 mm range and an angular displacement measurement device with a 100 mm diameter grating are both used for experiments. After testing, the linear measurement accuracy of the proposed algorithm is improved from 4.63 to 1.26 µm, and the angular displacement measurement accuracy is enhanced from 8.87 to

2.88

′
′

. The research in this paper provides a theoretical basis for high-performance displacement measurement.
High-throughput and controllable manufacturing of liquid crystal polymer planar microlens array for compact fingerprint imaging
Authors: Zhang Xin-Jun , Zhou Xiaohong , Yang Zi-Xing , Zhang Li-Xing , Huang Wenbin , Chen Linsen
Published: January 2022

The microlens array (MLA) with a small geometric footprint and unique performances, is the key enabler to push the development of photonic devices toward miniaturization, multi-function and large-scale integration. However, the realization of 100% fill-factor (FF) MLAs with high controllability and its mass manufacturing without complex steps has always been a difficult issue. Here, we propose an efficient, highly flexible and low-cost manufacturing approach for MLAs with a high FF via snapshot polarization patterning. The digitalized linear polarization pattern was distributed across the photo-alignment layer with both high efficiency and accuracy, enabling large-area liquid crystal MLA with parameter controllability from element to element. The MLA manufacturing process does not involve developing, etching and deposition steps and is suitable for industry up-scaling. We further proposed a novel compact compound-eye imaging system for biometrics with the obtained MLAs. The 100% FF MLA enables high light utilization efficiency and low background crosstalk, yielding compact biometrics indentation with high recognition accuracy. The realization of such planar optics would lead to a plethora of different miniaturized multiaperture imaging systems in the future.
A combined field study of Buruli ulcer disease in southeast Benin proposing preventive strategies based on epidemiological, geographic, behavioural and environmental analyses
Authors: Boccarossa Alexandra , Degnonvi Horace , Brou Télesphore Yao , Robbe-Saule Marie , Esnault Lucille , Boucaud Yan , Eveillard Matthieu , Gnimavo Ronald , Hounsou Saturnin , Djenontin Armel , Johnson Christian Roch , Fleuret Sébastien , Marion Estelle
Published: January 2022

Buruli ulcer is a neglected tropical disease caused by M. ulcerans, an environmental mycobacterium. This cutaneous infectious disease affects populations with poor access to sanitation, safe water and healthcare living in rural areas of West and Central Africa. Stagnant open bodies of surface water and slow-running streams are the only risk factor identified in Africa, and there is no human-to-human transmission. Appropriate and effective prevention strategies are required for populations living in endemic areas. Based on a multidisciplinary approach in an area in which Buruli ulcer is endemic in South Benin, we investigated the link between all human-environment interactions relating to unprotected water and behaviors associated with Buruli ulcer risk likely to affect incidence rates. We characterised the sources of water as well as water bodies and streams used by communities, by conducting a prospective case-control study directly coupled with geographic field observations, spatial analysis, and the detection of M. ulcerans in the environment. A full list of the free surface waters used for domestic activities was generated for a set of 34 villages, and several types of human behaviour associated with a higher risk of transmission were identified: (i) prolonged walking in water to reach cultivated fields, (ii) collecting water, (iii) and swimming. Combining the results of the different analyses identified the risk factor most strongly associated with Buruli ulcer was the frequency of contact with unprotected and natural water, particularly in regularly flooded or irrigated lowlands. We confirm that the use of clean water from drilled wells confers protection against Buruli ulcer. These specific and refined results provide a broader scope for the design of an appropriate preventive strategy including certain practices or infrastructures observed during our field investigations. This strategy could be improved by the addition of knowledge about irrigation practices and agricultural work in low-lying areas.
Hypoattenuating periportal halo on CT in a patient population can occur in presence of a variety of diseases
Authors: Dressel-Böhm Susann , Richter Henning , Kircher Patrick R. , Del Chicca Francesca
Published: January 2022

Many pathologies can occur in the periportal space and manifest as fluid accumulation, visible in Computed tomography (CT) images as a circumferential region of low attenuation around the intrahepatic portal vessels, called periportal halo (PPH). This finding is associated with different types of hepatic and extra-hepatic disease in humans and remains a non-specific sign of unknown significance in veterinary literature. The aim of this study was to investigate the prevalence of PPH in a population of patients undergoing CT examination and to assess the presence of lesions related to hepatic and extra-hepatic disease in presence of PPH. CT studies including the cranial abdomen of dogs and cats performed over a 5-year period were retrospectively reviewed. The prevalence of PPH was 15% in dogs and 1% in cats. 143 animals were included and the halo was classified as mild, moderate and severe, respectively in 51%, 34% and 15% of animals. The halo distribution was generalized in 79 cases, localized along the second generation of portal branches in 63, and along the first generation only in one. Hepatic disease was present in 58/143 and extra-hepatic disease in 110/143 of the cases. Main cause of hepatic (36%) and extra-hepatic disease (68%) was neoplasia. Associations between halo grades and neoplasia revealed to be not statistically significant (p = 0.057). In 7% of animals the CT examination was otherwise unremarkable. PPH is a non-specific finding, occurring in presence of a variety of diseases in the examined patient population.
Associations between infant and maternal characteristics measured at child age 5 months and maternal feeding styles and practices up to child age two years
Authors: Helle Christine , Hillesund Elisabet R. , Øverby Nina C.
Published: January 2022

Facilitating positive feeding practices from infancy may be an important strategy to prevent childhood overweight and obesity. Since the feeding situation early in life constitutes a bidirectional relationship, it is important to understand the impact of both maternal and infant characteristics on maternal feeding practices to intervene in a customized and tailored way. Few studies have concurrently examined associations between maternal and infant characteristics in relation to early maternal feeding practices. The aim of the present study was to explore potential associations between infant and maternal characteristics measured at child age five months, and maternal feeding styles and practices during the child’s first two years. Cross-sectional data from a Norwegian randomized controlled trial in which participants responded to questionnaires at child age 5 months (n = 474), 12 months (n = 293) and 24 months (n = 185) were used to explore potential associations. All maternal and child predictor variables were collected at child age five months. Maternal feeding styles and practices were mapped using subscales from theInfant Feeding Questionnaireat child age 5 and 12 months and theChild Feeding Questionnaireand theParental Feeding Style Questionnaireat child age 24 months. The subscale-scores were split into roughly equal tertiles, and the upper or lower tertile for the outcome of interest were used to create binary outcome variables. Multivariable binary logistic regression models were conducted for each outcome. We found that maternal education and mental health symptoms as well as infant weight, temperament and feeding mode were associated with maternal feeding styles and practices over time. Our findings indicate that risk factors which may have long-term implications for child weight and health outcomes can be identified early. Larger, population-based studies with a longitudinal design are needed to further explore these pathways.
Effects of mild-to-moderate sensorineural hearing loss and signal amplification on vocal emotion recognition in middle-aged–older individuals
Authors: Ekberg Mattias , Andin Josefine , Stenfelt Stefan , Dahlström Örjan
Published: January 2022

Previous research has shown deficits in vocal emotion recognition in sub-populations of individuals with hearing loss, making this a high priority research topic. However, previous research has only examined vocal emotion recognition using verbal material, in which emotions are expressed through emotional prosody. There is evidence that older individuals with hearing loss suffer from deficits in general prosody recognition, not specific to emotional prosody. No study has examined the recognition of non-verbal vocalization, which constitutes another important source for the vocal communication of emotions. It might be the case that individuals with hearing loss have specific difficulties in recognizing emotions expressed through prosody in speech, but not non-verbal vocalizations. We aim to examine whether vocal emotion recognition difficulties in middle- aged-to older individuals with sensorineural mild-moderate hearing loss are better explained by deficits in vocal emotion recognition specifically, or deficits in prosody recognition generally by including both sentences and non-verbal expressions. Furthermore a, some of the studies which have concluded that individuals with mild-moderate hearing loss have deficits in vocal emotion recognition ability have also found that the use of hearing aids does not improve recognition accuracy in this group. We aim to examine the effects of linear amplification and audibility on the recognition of different emotions expressed both verbally and non-verbally. Besides examining accuracy for different emotions we will also look at patterns of confusion (which specific emotions are mistaken for other specific emotion and at which rates) during both amplified and non-amplified listening, and we will analyze all material acoustically and relate the acoustic content to performance. Together these analyses will provide clues to effects of amplification on the perception of different emotions. For these purposes, a total of 70 middle-aged-older individuals, half with mild-moderate hearing loss and half with normal hearing will perform a computerized forced-choice vocal emotion recognition task with and without amplification.