bluuebunny/crossref_metadata_2025 huggingface dataset:
In Silico Structural Analysis Exploring Conformational Folding of Protein Variants in Alzheimer’s Disease
Authors: Efraimidis Evangelos , Krokidis Marios G. , Exarchos Themis P. , Lazar Tamas , Vlamos Panagiotis
Published: August 2023

Accurate protein structure prediction using computational methods remains a challenge in molecular biology. Recent advances in AI-powered algorithms provide a transformative effect in solving this problem. Even though AlphaFold’s performance has improved since its release, there are still limitations that apply to its efficacy. In this study, a selection of proteins related to the pathology of Alzheimer’s disease was modeled, with Presenilin-1 (PSN1) and its mutated variants in the foreground. Their structural predictions were evaluated using the ColabFold implementation of AlphaFold, which utilizes MMseqs2 for the creation of multiple sequence alignments (MSAs). A higher number of recycles than the one used in the AlphaFold DB was selected, and no templates were used. In addition, prediction by RoseTTAFold was also applied to address how structures from the two deep learning frameworks match reality. The resulting conformations were compared with the corresponding experimental structures, providing potential insights into the predictive ability of this approach in this particular group of proteins. Furthermore, a comprehensive examination was performed on features such as predicted regions of disorder and the potential effect of mutations on PSN1. Our findings consist of highly accurate superpositions with little or no deviation from experimentally determined domain-level models.
The Effect of Habitat on Insect Movements: Experimental Evidence from Wild-Caught Butterflies
Authors: Marcantonio Matteo , Voda Raluca , Da Re Daniele , Igot Quentin , Dennis Roger L. H. , Vielfaure Aurélien , Vanwambeke Sophie O. , Nieberding Caroline M.
Published: August 2023

There is broad evidence that the main driver of the ongoing biodiversity crisis is land-use change, which reduces and fragments habitats. The consequence of habitat fragmentation on behavioural responses of fitness-related traits in insects have been so far understudied. In herbivorous insects, oviposition-related behaviours determine access to larval food, and the fate of the next generation. We present a pilot study to assess differences in behaviours related to movement and oviposition in Limenitis camilla butterflies from Wallonia (Belgium), one of the most fragmented regions in Europe. We first quantified variation in functional habitat connectivity across Wallonia and found that fragmented habitats had more abundant, but less evenly distributed host plants of L. camilla. Secondly, we quantified the behaviours of field-caught L. camilla females originating from habitats with contrasted landscape connectivity in an outdoor experimental setting. We found differences in behaviours related to flight investment: butterflies from fragmented woodlands spent more time in departing flight, which we associated with dispersal, than butterflies from homogenous woodlands. Although results from this study should be interpreted with caution given the limited sample size, they provide valuable insights for the advancement of behavioural research that aims to assess the effects of global changes on insects.
European Corn Borer (Ostrinia nubilalis Hbn.) Bioecology in Eastern Romania
Authors: Pintilie Paula Lucelia , Trotuș Elena , Tălmaciu Nela , Irimia Liviu Mihai , Herea Monica , Mocanu Ionela , Amarghioalei Roxana Georgiana , Popa Lorena Diana , Tălmaciu Mihai
Published: August 2023

Between 2020 and 2021, we conducted research in eastern Romania to monitor the bioecology of the European corn borer (Ostrinia nubilalis Hbn.), an important pest of corn. The bioecology research established the pest stage duration (egg, larva, pupa, and moth), the flight curve, and the flight peak. The bioecological study occurred in the experimental corn field and a field cage. According to our findings, the insect has one generation per year. The European corn borer hibernates as a mature larva in corn residues and continues developing in the spring, when the weather warms. It pupates from May to July over 37 days. Analyzing the data recorded during the winters of 2020 and 2021, we observed that the warming trend favored the high survival of hibernating larvae (60.7%). Due to the large number of mature larvae that had favorable conditions during the winter, there is an intense flight, starting in June and ending in September. When the first moth was caught in the light trap, the ∑(tn-10) °C (sum of degree days) was 245.6 °C. In 2020, the flight was recorded for 94 days. In 2021, the European corn borer flight lasted 104 days. The initial egg masses were detected when the total of ∑(tn-10) °C reached 351.5 °C. Moths laid the eggs for 25 days, mostly during peak flight in late June and early July. The first larvae hatched when ∑(tn-10) °C totaled 438.4 °C, and stages III–V were recorded in the harvested crop. Understanding the bioecology of the European corn borer can offer valuable insights into managing population levels and identifying optimal timing for addressing infestations in corn crops.
Comparative Transcriptomic Analysis Reveals Adaptation Mechanisms of Bean Bug Riptortus pedestris to Different Food Resources
Authors: Zhang Ze-Long , Wang Xiao-Jing , Lu Hai-Bin , Huang Hai-Jian
Published: August 2023

The bean bug, Riptortus pedestris (Hemiptera: Heteroptera), poses a significant threat to soybean production, resulting in substantial crop losses. Throughout the soybean cultivation period, these insects probe and suck on various parts of plants, including leaves, pods, and beans. However, the specific mechanisms by which they adapt to different food resources remain unknown. In this study, we conducted gut transcriptomic analyses of R. pedestris fed with soybean leaves, pods, and beans. A total of 798, 690, and 548 differently expressed genes (DEGs) were monitored in G—pod vs. G—leaf (comparison of insect feeding on pods and leaves), G—bean vs. G—leaf (comparison of insect feeding on beans and leaves), and G—pod vs. G—bean (comparison of insect feeding on pods and beans), respectively. When fed on pods and beans, there was a significant increase in the expression of digestive enzymes, particularly cathepsins, serine proteases, and lipases. Conversely, when soybean leaves were consumed, detoxification enzymes, such as ABC transporters and 4-coumarate-CoA ligase, exhibited higher expression. Our findings indicate that R. pedestris dynamically regulates different metabolic pathways to cope with varying food resources, which may contribute to the development of effective strategies for managing this pest.
Cleavage Patterns of 9600 Embryos: The Importance of Irregular Cleavage
Authors: Shavit Maya , Gonen Daniel , Atzmon Yuval , Aslih Nardin , Bilgory Asaf , Shibli Abu-Raya Yasmin , Sharqawi Moamina , Estrada Garcia Daniela , Michaeli Mediea , Polotov Diana , Shalom-Paz Einat
Published: August 2023

This prospective, observational study investigated the incidence of irregular cleavage (IRC) among human embryos and its influence on IVF treatment outcomes. It included 1001 women who underwent 1976 assisted reproduction treatments during 2016–2021 in a single IVF clinic. Embryo morphokinetics were analyzed and evaluated for the association between IRC and women’s characteristics, treatment characteristics, and pregnancy outcomes. The incidence of IRC was 17.5% (1689/9632 embryos). Of these, 85% of the embryos had one IRC, 15% had multiple IRC and 35% of IRC events occurred during the embryo’s first cell cycle. IRC embryos were found to correlate with male factor (p = 0.01) and higher ICSI rate (p = 0.01). Age, BMI, parity, basal FSH level, stimulation protocol, and number of retrieved oocytes did not differ between groups. Embryos with early IRC or more than one IRC had lower blastulation rates (p = 0.01 for each). Fresh cycles with IRC embryos had a lower clinical pregnancy rate (p = 0.01) and embryos with early IRC had a lower live birth rate (p = 0.04) compared to embryos without IRC. Frozen transfer cycles of blastocyst embryos, with or without IRC, had comparable results. In conclusion, the number of abnormal cleavage events and their timing are important factors in the prognosis of the developing human embryo.
Machine Learning-Based Early Prediction of Sepsis Using Electronic Health Records: A Systematic Review
Authors: Islam Khandaker Reajul , Prithula Johayra , Kumar Jaya , Tan Toh Leong , Reaz Mamun Bin Ibne , Sumon Md. Shaheenur Islam , Chowdhury Muhammad E. H.
Published: August 2023

Background: Sepsis, a life-threatening infection-induced inflammatory condition, has significant global health impacts. Timely detection is crucial for improving patient outcomes as sepsis can rapidly progress to severe forms. The application of machine learning (ML) and deep learning (DL) to predict sepsis using electronic health records (EHRs) has gained considerable attention for timely intervention. Methods: PubMed, IEEE Xplore, Google Scholar, and Scopus were searched for relevant studies. All studies that used ML/DL to detect or early-predict the onset of sepsis in the adult population using EHRs were considered. Data were extracted and analyzed from all studies that met the criteria and were also evaluated for their quality. Results: This systematic review examined 1942 articles, selecting 42 studies while adhering to strict criteria. The chosen studies were predominantly retrospective (n = 38) and spanned diverse geographic settings, with a focus on the United States. Different datasets, sepsis definitions, and prevalence rates were employed, necessitating data augmentation. Heterogeneous parameter utilization, diverse model distribution, and varying quality assessments were observed. Longitudinal data enabled early sepsis prediction, and quality criteria fulfillment varied, with inconsistent funding–article quality correlation. Conclusions: This systematic review underscores the significance of ML/DL methods for sepsis detection and early prediction through EHR data.
Analysis of Discordant Findings between 3T Magnetic Resonance Imaging and Arthroscopic Evaluation of the Knee Meniscus
Authors: Van Dyck Pieter , Vandenrijt Jasper , Vande Vyvere Thijs , Snoeckx Annemiek , Heusdens Christiaan H. W.
Published: August 2023

Numerous studies have assessed the performance of magnetic resonance imaging (MRI) in detecting tears of the knee menisci using arthroscopy results as the gold standard, but few have concentrated on the nature of discordant findings. The purpose of this study was to analyze the discordances between 3T MRI and arthroscopic evaluation of the knee meniscus. Medical records of 112 patients who underwent 3T MRI and subsequent arthroscopy of the knee were retrospectively analyzed to determine the accuracy of diagnoses of meniscal tear. Compared with arthroscopy, there were 22 false-negative and 14 false-positive MR interpretations of meniscal tear occurring in 32 patients. Images with errors in diagnosis were retrospectively reviewed by two musculoskeletal radiologists in consensus and all errors were categorized as either unavoidable, equivocal or as interpretation error. Of 36 MR diagnostic errors, there were 16 (44%) unavoidable, 5 (14%) interpretation errors and 15 (42%) equivocal for meniscal tear. The largest categories of errors were unavoidable false-positive MRI diagnoses (71%) and equivocal false-negative MRI diagnoses (50%). All meniscal tears missed by MRI were treated with partial meniscectomy (n = 14) or meniscal repair (n = 8). Discordant findings between 3T MRI and arthroscopic evaluation of the knee meniscus remain a concern and primarily occur due to unavoidable and equivocal errors. Clinicians involved in the diagnosis and treatment of patients with meniscal tears should understand why and how the findings seen on knee MRI and arthroscopy may sometimes differ.
Effects of Non-Ablative Solid-State Vaginal Laser (SSVL) for the Treatment of Vulvovaginal Atrophy in Breast Cancer Survivors after Adjuvant Aromatase Inhibitor Therapy: Preliminary Results
Authors: Lubián-López Daniel M. , Butrón-Hinojo Carmen A. , Menjón-Beltrán Salomón , González-Mesa Ernesto , Tapiador-Albertos Silvia , Rodríguez-Jiménez Bibiana , Fiol-Ruiz Gabriel
Published: August 2023

Background: One of the side effects of anti-estrogen treatments in breast cancer survivors (BCSs), especially with aromatase inhibitor (AI) treatment, is the frequent appearance of vulvo-vaginal atrophy (VVA). We aim to evaluate the efficacy, safety and feasibility of a new type of non-ablative Solid-State Vaginal Laser (SSVL) treatment in BCSs with VVA. Methods: A total of 30 BCSs with a history of AI use and symptoms of VVA were treated with a non-ablative SSVL (LASEmaR 1500™-EUFOTON)in this non-randomized pilot study. The effects of the laser have been evaluated at baseline, 10 wk and 24 wk using a visual analogue scale (VAS), the Vaginal Health Index (VHI), the Vulvar Health Index (VuHI), the Female Sexual Function Index (FSFI), the EORTC QLQ-BR23, the Vaginal Maturation Index (VMI) and vaginal pH. Results: At 10-week follow-up vs. baseline there were no statistically significant differences in FSFI, lubrication and EORTC QLQ-BR23. In all the subjective (dyspareunia, VHI, VuHI, FSFI, QLQ) and objective parameters (VMI and pH) there was a statistically significant improvement at the 6-month follow-up. Satisfaction was very high (4.7 out of 5), with 95.7% of patients being satisfied, more than or very satisfied. Conclusions: Preliminary results of SSVL treatment of VVA and dyspareunia in BCSs after AI treatment suggest clinical improvement, without relevant side effects and with a high degree of satisfaction
Dual PPRαϒ Agonists for the Management of Dyslipidemia: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Authors: Menezes Junior Antonio da Silva , Oliveira Vinícius Martins Rodrigues , Oliveira Izadora Caiado , de Sousa André Maroccolo , Santana Ana Júlia Prego , Carvalho Davi Peixoto Craveiro , Paro Piai Ricardo Figueiredo , Matos Fernando Henrique , de Paiva Arthur Marot , Reis Gabriel Baêta Branquinho
Published: August 2023

Saroglitazar is a novel medication for dyslipidemia, but its specific effects remain unclear. Therefore, we performed a systematic review and meta-analysis to assess the efficacy and safety of saroglitazar for managing dyslipidemia. The PubMed, Scopus, and EMBASE databases were systematically searched for randomized controlled trials (RCTs) comparing 2 and 4 mg of saroglitazar with placebos for treating dyslipidemia. A random-effects model calculated the pooled mean differences for continuous outcomes with 95% confidence intervals. The study included seven RCTs involving 1975 patients. Overall, 340 (31.0%) and 513 (46.8%) participants received 2 and 4 mg of saroglitazar, respectively; 242 (22.11%) received the placebo. The mean ages ranged from 40.2 to 62.6 years, and 436 (39.8%) were women. Compared to the control group, 4 mg of saroglitazar significantly decreased the triglyceride and low-density lipoprotein (LDL) cholesterol levels but did not affect the high-density lipoprotein cholesterol level. Furthermore, the alanine aminotransferase level significantly decreased, the creatine level significantly increased, and body weight did not differ between the groups. Finally, 4 mg of saroglitazar, compared to 2 mg, significantly lowered the triglyceride level. Saroglitazar (4 mg) may be an effective treatment, but safety concerns remain.
Harnessing Machine Learning for Prediction of Postoperative Pulmonary Complications: Retrospective Cohort Design
Authors: Kim Jong-Ho , Cheon Bo-Reum , Kim Min-Guan , Hwang Sung-Mi , Lim So-Young , Lee Jae-Jun , Kwon Young-Suk
Published: August 2023

Postoperative pulmonary complications (PPCs) are significant causes of postoperative morbidity and mortality. This study presents the utilization of machine learning for predicting PPCs and aims to identify the important features of the prediction models. This study used a retrospective cohort design and collected data from two hospitals. The dataset included perioperative variables such as patient characteristics, preexisting diseases, and intraoperative factors. Various algorithms, including logistic regression, random forest, light-gradient boosting machines, extreme-gradient boosting machines, and multilayer perceptrons, have been employed for model development and evaluation. This study enrolled 111,212 adult patients, with an overall incidence rate of 8.6% for developing PPCs. The area under the receiver-operating characteristic curve (AUROC) of the models was 0.699–0.767, and the f1 score was 0.446–0.526. In the prediction models, except for multilayer perceptron, the 10 most important features were obtained. In feature-reduced models, including 10 important features, the AUROC was 0.627–0.749, and the f1 score was 0.365–0.485. The number of packed red cells, urine, and rocuronium doses were similar in the three models. In conclusion, machine learning provides valuable insights into PPC prediction, significant features for prediction, and the feasibility of models that reduce the number of features.
Vesicoscopic vs. Open Ureteral Reimplantation According to Cohen and Leadbetter-Politano for Vesicoureteral Reflux
Authors: Kruppa Christian , Wilke Alexandra , Hörz Carola , Kosk Thomas , Hörz Tina , Fitze Guido , Schuchardt Katrin
Published: August 2023

Background: The minimally invasive implementations of the established open methods for the correction of primary vesicoureteral reflux have proven to be successful in terms of feasibility and safety. The aim of this study was to investigate to what extent pediatric patients benefit from vesicoscopic operations. Methods: Between 2010 and 2022, 224 children (359 ureters) underwent ureteral reimplantation for vesicoureteral reflux in our clinic. Children, operated on according to the COHEN technique, underwent an open approach in 39 cases, whereas 151 patients were operated on vesicoscopically. A total of thirty-four children have received a ureteral reimplantation according to the LEADBETTER-POLITANO technique: twenty-nine openly and five vesicoscopically. The open and vesicoscopic groups were compared with regards to perioperative data and postoperative course. Results: The mean operating time was significantly shorter for open than for the vesicoscopic procedures in the COHEN group (99 vs. 149 min, p < 0.001). Similarly, a comparison of ureteral reimplantations, according to LEADBETTER-POLITANO, favored the open procedure, although this was not significant (161 vs. 196 min, p = 0.135). There was no significant difference in the recurrence rate of all the groups. All procedures remained within the accepted range with a success rate of at least 96%. In the postoperative course, a significantly shorter hospital stay (4.1 vs. 7.9 days, p < 0.001 for COHEN-patients; 5.6 vs. 9.2 days for LEADBETTER-POLITANO-patients), as well as a significantly lower need for continuous analgesic administration, was observed for the vesicoscopic approaches of both methods (0.8 days in both vesicoscopic groups vs. 3.7 resp. 3.8 days in open groups, p < 0.001). In addition, the time of bladder drainage was significantly shorter in open techniques (7.2 vs. 1.9 days, p < 0.001 for COHEN-patients; 3 vs. 8.7 days for LEADBETTER-POLITANO-patients). Conclusions: For almost all underlying causes, the surgical treatment of vesicoureteral reflux can be performed vesicoscopically, even if bilateral, in one session. Patients benefit significantly from the use of minimally invasive surgery in the postoperative course with faster mobilization, less need for analgesics, a shorter bladder drainage and a reduced hospital stay, compared with its open counterparts.
Morphological Hallmarks of Classical Fabry Disease: An Ultrastructural Study in a Large Spanish Family
Authors: San Millán-Tejado Beatriz , Navarro Carmen , Fernández-Martín Julián , Rivera Alberto , Viéitez Irene , Teijeira Susana , Ortolano Saida
Published: August 2023

Fabry disease (FD) is a rare lysosomal disorder caused by α-galactosidase A deficiency, and it leads to the systemic deposition of globotriasylceramide. Demonstrations of the storage material in biopsies support this diagnosis. We report a histological and ultrastructural study of biopsies that were performed on 11 individuals from a family with the variant p.Gln279Arg in GLA, which is associated with the classical phenotype of Fabry disease. Intralysosomal deposits were found in all biopsies, corresponding to the skin, kidney, and endomyocardium in both sexes and at different ages. In nine of the skin biopsies, deposits were analysed by immunofluorescence and quantified at the ultrastructural level. Then, the findings were compared according to sex, genotype, and treatment. The quantification of the deposits in the skin biopsies revealed a broader involvement in men than in women. A significant clearance of the deposits was observed in one case after treatment. Tissue involvement was remarkable at diagnosis in all individuals. The findings from the skin biopsies were demonstrative of classic FD, thus supporting the diagnosis; repeated biopsy analyses suggested the benefit of early treatment.
TNFα rs1800629 Polymorphism and Response to Anti-TNFα Treatment in Behçet Syndrome: Data from an Italian Cohort Study
Authors: Padula Maria Carmela , Padula Angela Anna , D’Angelo Salvatore , Lascaro Nancy , Radice Rosa Paola , Martelli Giuseppe , Leccese Pietro
Published: August 2023

Tumor Necrosis Factor-alpha (TNFα) rs1800629 (-308G>A) is a single nucleotide polymorphism (SNP) related to variable responses to anti-TNFα therapy. This therapy is efficient in severe and refractory manifestation of Behçet syndrome (BS), an auto-inflammatory systemic vasculitis. We investigated (1) the association between rs1800629 genotypes and responses to therapy and (2) the correlation between SNP and clinical patterns in a cohort of 74 BS Italian patients receiving anti-TNFα therapy with a follow-up of at least 12 months. The rs1800629 was genotyped through amplification, direct sequencing and bioinformatics analyses. The rs1800629 GG and GA genotypes were assessed as predictors of outcomes dividing the patients between therapy responders and non-responders. The rs1800629 GG and GA genotypes were found, respectively, in 59/74 (79.7%) and 15/74 BS patients (21.3%) (p < 0.05). We identified 16/74 (21.9%) non-responder patients, of which 9/16 (56.3%) showed the GG genotype and 7/16 (43.7%) the GA genotype. A total of 50/58 (86.2%) responder patients showed the GG genotype, and 8/58 (13.8%) the GA genotype (p < 0.05). The percentage of non-responder females (68.8%) was significantly higher than non-responder males (31.2%) (p < 0.05). No correlation between SNP and clinical patterns was observed. To successfully include rs1800629 as a predictive biomarker of TNFα inhibitor response, genome-wide association studies in larger, well-characterised cohorts are required.
Cardiac Troponin I but Not N-Terminal Pro-B-Type Natriuretic Peptide Predicts Outcomes in Cardiogenic Shock
Authors: Schupp Tobias , Rusnak Jonas , Forner Jan , Weidner Kathrin , Ruka Marinela , Egner-Walter Sascha , Dudda Jonas , Bertsch Thomas , Kittel Maximilian , Behnes Michael , Akin Ibrahim
Published: August 2023

This study investigates the prognostic value of cardiac troponin I (cTNI) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in patients with cardiogenic shock (CS). Data regarding the prognostic value of cardiac biomarkers in CS is scarce, furthermore, most studies were restricted to CS patients with acute myocardial infarction (AMI). Therefore, consecutive patients with CS from 2019 to 2021 were included. Blood samples were retrieved from day of disease onset (day 1) and on days 2, 3 and 4 thereafter. The prognostic value of cTNI and NT-proBNP levels was tested for 30-day all-cause mortality. Statistical analyses included univariable t-tests, Spearman’s correlations, Kaplan–Meier analyses and multivariable Cox proportional regression analyses. A total of 217 CS patients were included with an overall rate of all-cause mortality of 56% at 30 days. CTNI was able to discriminate 30-day non-survivors (area under the curve (AUC) = 0.669; p = 0.001), whereas NT-proBNP (AUC = 0.585; p = 0.152) was not. The risk of 30-day all-cause mortality was higher in patients with cTNI levels above the median (70% vs. 43%; log rank p = 0.001; HR = 2.175; 95% CI 1.510–3.132; p = 0.001), which was observed both in patients with (71% vs. 49%; log rank p = 0.012) and without AMI-related CS (69% vs. 40%; log rank p = 0.005). The prognostic impact of cTNI was confirmed after multivariable adjustment (HR = 1.915; 95% CI 1.298–2.824; p = 0.001). In conclusion, cTNI—but not NT-proBNP—levels discriminated 30-day all-cause mortality in CS patients.
Internet Usage among Senior Citizens: Self-Efficacy and Social Influence Are More Important than Social Support
Authors: Pejić Bach Mirjana , Ivančić Lucija , Bosilj Vukšić Vesna , Stjepić Ana-Marija , Milanović Glavan Ljubica
Published: August 2023

For more than two decades, developed countries have been confronted with two trends that have implications for the emergence of engaging senior citizens in the digital environment. On the one hand, there is an increasing proportion of senior citizens in the total population. On the other hand, the application of ICT in all areas of life and business is accelerating. This paper investigates the relationship between self-efficacy, social support, and social influence on Internet usage among senior citizens in Croatia. Survey research was conducted on a sample of Croatian senior citizens, and a structural equation mode was developed for testing the research hypothesis. Self-efficacy influenced both the Intensity and obstacles of Internet usage in a positive and negative manner, respectively. Social influence directly decreased the obstacles to Internet usage, while the relationship with the Intensity of the Internet was indirect through self-efficacy. Social support had only an indirect association with Intensity of Internet usage. Results have relevant implications for programmes aiming to enhance Internet usage among senior citizens, which should focus on the educational programmes fostering perceived self-efficacy of Internet usage among senior citizens.
Relaxing Retinotomy in Recurrent and Refractory Full-Thickness Macular Holes: The State of the Art
Authors: Ventre Luca , Mus Erik , Maradei Fabio , Imparato Roberto , Pintore Giulia , Parisi Guglielmo , Marolo Paola , Reibaldi Michele
Published: August 2023

The prevailing standard of care for primary repair of full-thickness macular holes (FTMHs) is pars plana vitrectomy with internal limiting membrane (ILM) peeling and gas tamponade, as it gives a high closure rate of roughly 90%. On the other hand, the surgical management of recurrent and refractory FTMHs represents, so far, a demanding and debated subject in vitreoretinal surgery since various approaches have been proposed, with no consensus concerning both adequate selection criteria and the best surgical approach. In addition, the existence of multiple case series/interventional studies showing comparable results and the lack of studies with a direct comparison of multiple surgical techniques may lead to uncertainty. We present an organized overview of relaxing retinotomy technique, a surgical approach available nowadays for the secondary repair of recurrent and refractory FTMHs. Besides the history and the description of the various techniques to perform relaxing retinotomies, we underline the results and the evidence available to promote the use of this surgical approach.
Effects of Acute Long- versus Short-Interval High-Intensity Interval Training on Attention and Psychological States in a Sample of Male and Female Adolescents: A Pilot Study
Authors: Slimani Maamer , Issaoui Mahdi , Znazen Hela , Hammami Amri , Bragazzi Nicola
Published: August 2023

The aim of this study was to assess the effect of acute short- versus long-interval high-intensity interval training (HIIT) on cognitive performance and psychological states in secondary school students. Fifteen secondary school students (nine males and six females: mean age = 16.2 ± 0.4 years, mean Body Mass Index = 21.2 ± 1.5 kg/m2, and maximum oxygen uptake = 42.2 ± 5.9 mL/kg/min) participated in the current study. They performed one of the following three sessions in a randomized order: (i) a long-interval HIIT (LIHIIT), (ii) a short-interval HIIT (SIHIIT), and (iii) a control condition (CC). Cognitive performance and perceived exertion were assessed pre and immediately post each condition using the d2 test and the Rating of Perceived Exertion (RPE) tool, respectively. Mood state was quantified using the Brunel Mood Scale (BRUMS) questionnaire immediately post each condition. The findings reported higher concentration performance in the SIHIIT compared to the LIHIIT condition (p = 0.043) and the CC (p < 0.001) and in the LIHIIT compared to the CC (p = 0.023). Moreover, the total count of errors was higher in the CC than in the LIHIIT (p = 0.01) and in the SIHIIT conditions (p < 0.001) and in the LIHIIT than in the SIHIIT condition (p = 0.03). RPE value was higher in the LIHIIT and SIHIIT conditions than in the CC (both p < 0.001), whereas no statistically significant difference between LIHIIT and SIHIIT conditions (p = 0.24) was found. Regarding the BRUMS, a significant difference between conditions in the fatigue subscale was found, being higher in LIHIIT with respect to SIHIIT (p = 0.03) and CC (p < 0.05). Vigor differed between conditions, with a higher value than in the LIHIIT (p = 0.04) and CC (p < 0.001). All the remaining subscales did not significantly differ between conditions (p > 0.05). Practitioners may implement short-interval HIIT prior to any tasks that require high levels of visual attention.
Planetary Scale Information Transmission in the Biosphere and Technosphere: Limits and Evolution
Authors: Lingam Manasvi , Frank Adam , Balbi Amedeo
Published: August 2023

Information transmission via communication between agents is ubiquitous on Earth, and is a vital facet of living systems. In this paper, we aim to quantify this rate of information transmission associated with Earth’s biosphere and technosphere (i.e., a measure of global information flow) by means of a heuristic order-of-magnitude model. By adopting ostensibly conservative values for the salient parameters, we estimate that the global information transmission rate for the biosphere might be ∼1024 bits/s, and that it may perhaps exceed the corresponding rate for the current technosphere by ∼9 orders of magnitude. However, under the equivocal assumption of sustained exponential growth, we find that information transmission in the technosphere can potentially surpass that of the biosphere ∼90 years in the future, reflecting its increasing dominance.
Stability Analysis of Plate—Screw Fixation for Femoral Midshaft Fractures
Authors: Basirom Izzawati , Daud Ruslizam , Ijaz Muhammad Farzik , Rojan Mohd Afendi , Basaruddin Khairul Salleh
Published: August 2023

An understanding of the biomechanical characteristics and configuration of flexible and locked plating in order to provide balance stability and flexibility of implant fixation will help to construct and promote fast bone healing. The relationship between applied loading and implantation configuration for best bone healing is still under debate. This study aims to investigate the relationship between implant strength, working length, and interfragmentary strain (εIFM) on implant stability for femoral midshaft transverse fractures. The transverse fracture was fixed with a fragment locking compression plate (LCP) system. Finite element analysis was performed and subsequently characterised based on compression loading (600 N up to 900 N) and screw designs (conventional and locking) with different penetration depths (unicortical and bicortical). Strain theory was used to evaluate the stability of the model. The correlation of screw configuration with screw type shows a unicortical depth for both types (p < 0.01) for 700 N and 800 N loads and (p < 0.05) for configurations 134 and 124. Interfragmentary strain affected only the 600 N load (p < 0.01) for the bicortical conventional type (group BC), and the screw configurations that were influenced were 1234 and 123 (p < 0.05). The low steepness of the slope indicates the least εIFM for the corresponding biomechanical characteristic in good-quality stability. A strain value of ≤2% promotes callus formation and is classified as absolute stability, which is the minimum required value for the induction of callus and the maximum value that allows bony bridging. The outcomes have provided the correlation of screw configuration in femoral midshaft transverse fracture implantation which is important to promote essential primary stability.
Advances in Electrical Discharge Machining of Insulating Ceramics
Authors: Grigoriev Sergey N. , Volosova Marina A. , Okunkova Anna A.
Published: August 2023

There are two main ways of carrying out the electrical discharge machining of the insulating ceramics: changing the electrical and chemical properties of ceramics due to additives in producing composites/nanocomposites and changing the electrical and chemical properties in the interelectrode gap. This review summarizes and analyzes the current data on the machinability in water suspension and hydrocarbons depending on the electrical properties of the ceramic composites and assisting means such as coating and powder. There are provided the existing approaches and original methods for solving the global problem of the electrical discharge machining of insulating ceramics, suggesting further development of the existing methods since, up to now, the experimental research is non-systemic. The dependencies of the machinability on the electrical properties of conductive ceramic composites, the specific electrical resistance of the assisting coating, and the assisting powder’s band gap and concentration for machining insulating ceramics are revealed. The higher the electrical conductivity, the higher the machinability of ceramic composites, and the lower the band gap, the higher the machinability for insulating ceramics. Two technological gaps were revealed in the powder’s concentration that can be a particular case of logarithmic decrement of attenuation. The proposed approach suggests using assisting powder with the lower band gap.
Effect of Initial Crack Position on Crack Propagation Behaviors of Heavy-Duty Transmission Gear
Authors: Zhang Yingtao , Tang Zirong , Zhao Lijuan , Gong Benxiang , Wang Gang , Li Zhichao
Published: August 2023

The tooth bending fatigue fracture is caused by the alternating loads for the heavy-duty transmission gears. The crack initiation and propagation are the two major parts in the failure process. The crack propagation behavior is mainly affected by initial crack position except for the load and material properties. In this paper, the crack propagation model of a gear is established under the considering of crack initiation location by using extended finite element method (XFEM). The model accuracy is verified by testing results of strain and fractography by conducting the single-tooth bending fatigue experiment. The influence of crack initiation locations on subsequent crack propagation behavior is analyzed. The crack length in the tooth width direction and depth direction is faster when the initial crack is located in the middle of root surface. The crack growth rate is lower for the initial crack located in the surface close to the end surface of the gear.
Corrosion-Fatigue Performance of 3D-Printed (L-PBF) AlSi10Mg
Authors: Linder Clara , Vucko Flavien , Ma Taoran , Proper Sebastian , Dartfeldt Erik
Published: August 2023

Additive manufacturing (AM) allows for optimized part design, reducing weight compared to conventional manufacturing. However, the microstructure, surface state, distribution, and size of internal defects (e.g., porosities) are very closely related to the AM fabrication process and post-treatment operations. All these parameters can have a strong impact on the corrosion and fatigue performance of the final component. Thus, the fatigue-corrosion behavior of the 3D-printed (L-PBF) AlSi10Mg aluminum alloy has been investigated. The influence of load sequence (sequential vs. combined) was explored using Wöhler diagrams. Surface roughness and defects in AM materials were examined, and surface treatment was applied to improve surface quality. The machined specimens showed the highest fatigue properties regardless of load sequence by improving both the roughness and removing the contour layer containing the highest density of defect. The impact of corrosion was more pronounced for as-printed specimens as slightly deeper pits were formed, which lowered the fatigue-corrosion life. As discussed, the corrosion, fatigue and fatigue-corrosion mechanisms were strongly related to the local microstructure and existing defects in the AM sample.
Special Issue: Porous Ceramics, Glasses and Composites, Volume II
Authors: Baino Francesco
Published: August 2023

This Special Issue, titled “Porous Ceramics, Glasses and Composites, Volume II”, aims to present an up-to-date overview of the synthesis/fabrication, characterization, and applications of porous materials, with a special focus on ceramics, glasses, and composites [...]
Axion Field Influence on Josephson Junction Quasipotential
Authors: Grimaudo Roberto , Valenti Davide , Spagnolo Bernardo , Troisi Antonio , Filatrella Giovanni , Guarcello Claudio
Published: August 2023

The direct effect of an axion field on Josephson junctions is analyzed through the consequences on the effective potential barrier that prevents the junction from switching from the superconducting to the finite-voltage state. We describe a method to reliably compute the quasipotential with stochastic simulations, which allows for the spanning of the coupling parameter from weakly interacting axion to tight interactions. As a result, we obtain an axion field that induces a change in the potential barrier, therefore determining a significant detectable effect for such a kind of elusive particle.
Grain Structure Evolution in 6013 Aluminum Alloy during High Heat-Input Friction-Stir Welding
Authors: Kalinenko Alexander , Dolzhenko Pavel , Malopheyev Sergey , Yuzbekova Diana , Shishov Ivan , Mishin Vasiliy , Mironov Sergey , Kaibyshev Rustam
Published: August 2023

This work was undertaken to evaluate the influence of friction-stir welding (FSW) under a high-heat input condition on microstructural evolution. Given the extreme combination of deformation conditions associated with such an FSW regime (including the highest strain, temperature, and strain rate), it was expected to result in an unusual structural response. For this investigation, a commercial 6013 aluminum alloy was used as a program material, and FSW was conducted at a relatively high spindle rate of 1100 rpm and an extremely low feed rate of 13 mm/min; moreover, a Ti-6Al-4V backing plate was employed to reduce heat loss during welding. It was found that the high-heat-input FSW resulted in the formation of a pronounced fine-grained layer at the upper weld surface. This observation was attributed to the stirring action exerted by the shoulder of the FSW tool. Another important issue was the retardation of continuous recrystallization. This interesting phenomenon was explained in terms of a competition between recrystallization and recovery at high temperatures. Specifically, the activation of recovery should reduce dislocation density and thus retard the development of deformation-induced boundaries.
Microstructure and Strength of Ti-6Al-4V Samples Additively Manufactured with TiC Heterogeneous Nucleation Site Particles
Authors: Watanabe Yoshimi , Yamada Shintaro , Chiba Tadachika , Sato Hisashi , Miura Seiji , Abe Kenshiro , Kato Tomotsugu
Published: August 2023

Our research aims to investigate the fabrication of additively manufactured (AMed) Ti-6Al-4V samples under reduced power with the addition of TiC heterogeneous nucleation site particles. For this aim, Ti-6Al-4V samples are fabricated with and without TiC heterogeneous nucleation site particles using an EOS M 290 machine under optimal parameters and reduced power conditions. The microstructure and tensile behavior of the produced samples were studied. In addition, a single-track test was performed to obtain a good understanding of the suppression of gas pores and balling formation with the addition of TiC heterogeneous nucleation site particles. It was found that the formation of gas pores and balling was suppressed with the addition of heterogeneous nucleation site particles within the metallic powder.
A Review of Solar-Coupled Phase Change Materials in Buildings
Authors: Aziz Shahid , Talha Tariq , Mazhar Abdur Rehman , Ali Junaid , Jung Dong-Won
Published: August 2023

Buildings use a significant percentage of the total energy consumed worldwide. Striving for energy conservation within buildings is of prime concern for researchers. Hence, scientists are aggressively exploring new energy storage and supply methods to reduce exorbitantly fluctuating energy demands and increase the share of renewable energy in building energy consumption. Solar systems that incorporate phase change materials (PCMs) for thermal storage have significant potential to serve in this context. These systems are not yet able to endure the significant energy demands, but they are being continually improved. The aim of this paper is to explore the existing solar PCM systems that are being studied or that are installed for use in indoor heating/cooling. As per the outcome of this systematic review, it has been observed that when coupled with solar thermal energy, the configuration of PCMs can either use passive or active techniques. Passive techniques are usually less efficient and more costly to implement in a building structure, resulting in active heat exchangers being widely implemented with better technical and economic results. At the same time, it has been observed that for most domestic buildings, organic PCMs with phase change temperatures of up to 42 °C and thermal conductivities of up to 0.56 W/m.K are most suitable for integration in solar thermal energy production. Hybrid systems are also commonly used for larger commercial buildings, in which the solar PCM system (SPCMS) provides a fraction of the total load. Additionally, the Stefan number is the most common technical parameter that is used to assess this performance, along with the effective thermal conductivity of the PCM after using enhancement techniques. The key economic indicator is annual savings per year, with most SPCMSs having a payback period of between 6 to 30 years. This review provides designers and researchers with key insights in terms of formulating a basis in the domain of coupling PCMs with solar thermal energy, especially within non-industrial buildings.
Materials in the Na2O–CaO–SiO2–P2O5 System for Medical Applications
Authors: Kaimonov Maksim R. , Safronova Tatiana V.
Published: August 2023

Calcium phosphate materials and materials based on silicon dioxide have been actively studied for more than 50 years due to their high biocompatibility and bioactivity. Hydroxyapatite and tricalcium phosphate are the most known among calcium phosphate materials, and Bioglass 45S5 is the most known material in the Na2O–CaO–SiO2–P2O5 system. Each of these materials has its application limits; however, some of them can be eliminated by obtaining composites based on calcium phosphate and bioglass. In this article, we provide an overview of the role of silicon and its compounds, including Bioglass 45S5, consider calcium phosphate materials, talk about the limits of each material, demonstrate the potential of the composites based on them, and show the other ways of obtaining composite ceramics in the Na2O–CaO–SiO2–P2O5 system.
Polar GaN Surfaces under Gallium Rich Conditions: Revised Thermodynamic Insights from Ab Initio Calculations
Authors: Kempisty Pawel , Kawka Karol , Kusaba Akira , Kangawa Yoshihiro
Published: August 2023

This paper presents an improved theoretical view of ab initio thermodynamics for polar GaN surfaces under gallium-rich conditions. The study uses density functional theory (DFT) calculations to systematically investigate the adsorption of gallium atoms on GaN polar surfaces, starting from the clean surface and progressing to the metallic multilayer. First principles phonon calculations are performed to determine vibrational free energies. Changes in the chemical potential of gallium adatoms are determined as a function of temperature and surface coverage. Three distinct ranges of Ga coverage with very low, medium, and high chemical potential are observed on the GaN(000-1) surface, while only two ranges with medium and high chemical potential are observed on the GaN(000-1) surface. The analysis confirms that a monolayer of Ga adatoms on the GaN(000-1) surface is highly stable over a wide range of temperatures. For a second adlayer at higher temperatures, it is energetically more favorable to form liquid droplets than a uniform crystalline adlayer. The second Ga layer on the GaN(0001) surface shows pseudo-crystalline properties even at a relatively high temperature. These results provide a better thermodynamic description of the surface state under conditions typical for molecular beam epitaxy and offer an interpretation of the observed growth window.
Asymmetric Plasmonic Moth-Eye Nanoarrays with Side Opening for Broadband Incident-Angle-Insensitive Antireflection and Absorption
Authors: Xia Rong , Li Yang , You Song , Lu Chunhua , Xu Wenbin , Ni Yaru
Published: August 2023

Plasmonic absorbers with broadband angle-insensitive antireflection have attracted intense interests because of its wide applications in optical devices. Hybrid surfaces with multiple different sub-wavelength array units can provide broadened antireflection, while many of these antireflective surfaces only work for specific angles and require high complexity of nanofabrication. Here, a plasmonic asymmetric nanostructure composed of the moth-eye dielectric nanoarray partially modified with the top Ag nanoshell providing a side opening for broadband incident-angle-insensitive antireflection and absorption, is rationally designed by nanoimprinting lithography and oblique angle deposition. This study illustrates that the plasmonic asymmetric nanostructure not only excites strong plasmonic resonance, but also induces more light entry into the dielectric nanocavity and then enhances the internal scattering, leading to optimized light localization. Hence, the asymmetric nanostructure can effectively enhance light confinement at different incident angles and exhibit better antireflection and the corresponding absorption performance than that of symmetric nanostructure over the visible wavelengths, especially suppressing at least 16.4% lower reflectance in the range of 645–800 nm at normal incidence.Moreover, the reflectance variance of asymmetric nanostructure with the incident angle changing from 5° to 60° is much smaller than that of symmetric nanostructure, making our approach relevant for various applications in photocatalysis, photothermal conversion, and so on.
Laser Processing and Multi-Energy Field Manufacturing of High-Performance Materials
Authors: Chen Xiaoxiao , Zhang Yaou , Li Anhai
Published: August 2023

The laser is one of the major inventions of the 20th century, along with atomic energy, the computer and semiconductors [...]