bluuebunny/crossref_metadata_2025 huggingface dataset:
Lignocellulose-Degrading Microbial Communities in Landfill Sites Represent a Repository of Unexplored Biomass-Degrading Diversity
Authors: Ransom-Jones Emma , McCarthy Alan J. , Haldenby Sam , Doonan James , McDonald James E.
Published: August 2017

The microbial conversion of lignocellulosic biomass for biofuel production represents a renewable alternative to fossil fuels. However, the discovery of new microbial enzymes with high activity is critical for improving biomass conversion processes. While attempts to identify superior lignocellulose-degrading enzymes have focused predominantly on the animal gut, biomass-degrading communities in landfill sites represent an unexplored resource of hydrolytic enzymes for biomass conversion. Here, we identified
Firmicutes
,
Spirochaetes
, and
Fibrobacteres
as key phyla in the landfill cellulolytic community, detecting 8,371 carbohydrate active enzymes (CAZymes) that represent at least three of the recognized strategies for cellulose decomposition. These data highlight substantial hydrolytic enzyme diversity in landfill sites as a source of new enzymes for biomass conversion.
Whole-Genome Sequencing of Human Clinical Klebsiella pneumoniae Isolates Reveals Misidentification and Misunderstandings of Klebsiella pneumoniae, Klebsiella variicola, and Klebsiella quasipneumoniae
Authors: Long S. Wesley , Linson Sarah E. , Ojeda Saavedra Matthew , Cantu Concepcion , Davis James J. , Brettin Thomas , Olsen Randall J.
Published: August 2017

Klebsiella pneumoniae
is a serious human pathogen associated with resistance to multiple antibiotics and high mortality.
K. variicola
and
K. quasipneumoniae
are closely related organisms that are generally considered to be less-virulent opportunistic pathogens. We used a large, comprehensive, population-based strain collection and whole-genome sequencing to investigate infections caused by these organisms in our hospital system. We discovered that
K. variicola
and
K. quasipneumoniae
isolates are often misidentified as
K. pneumoniae
by routine clinical microbiology diagnostics and frequently cause severe life-threatening infections similar to
K. pneumoniae
. The presence of KPC in
K. variicola
and
K. quasipneumoniae
strains as well as NDM-1 metallo-beta-lactamase in one
K. variicola
strain is particularly concerning because these genes confer resistance to many different beta-lactam antibiotics. The sharing of plasmids, as well as evidence of homologous recombination, between these three species of
Klebsiella
is cause for additional concern.
Invasive lobular breast carcinoma metastasising to the rectum
Authors: Cherian Nishant , Qureshi Nafees Ahmad , Cairncross Callum , Solkar Mamoon
Published: August 2017

Gastrointestinal (GI) metastasis from a primary breast carcinoma is uncommon, with the rectum being one of the least reported sites in the literature. We report a case of a 79-year-old woman who underwent treatment for an infiltrative lobular carcinoma of the right breast with nodal involvement, and 10 years later developed recurrence in the form of rectal metastasis. Spread to the GI tract is most commonly seen with lobular breast carcinomas. Any patient with a history of breast cancer presenting typically or atypically with abdominal symptoms or altered bowel habit should raise a high index of suspicion for recurrent or metastatic disease.
Cervical facet joint septic arthritis: a real pain in the neck
Authors: Sethi Sahiba , Vithayathil Mathew Kurian
Published: August 2017

A 64-year-old man with a complex medical history and previous cervical arthritis with discectomy presents with a 2-day history of neck and lower back pain and shortness of breath, associated with left-sided muscle weakness. He has a fever with severe sepsis causing acute renal failure. MRI spine shows evidence of left cervical facet joint septic arthritis at C6-T1. He required 6 weeks of intravenous antibiotics and intensive support with ventilation and haemofiltration. After completion of antibiotics, he made a full recovery and regained neurological function before discharge.
Improving specialist palliative care in residential care for older people: a checklist to guide practice
Authors: Forbat Liz , Chapman Michael , Lovell Clare , Liu Wai-Man , Johnston Nikki
Published: August 2017

Objectives

Palliative care needs rounds are triage meetings that have been introduced in residential care for older adults to help identify and prioritise care for people most at risk for unplanned dying with inadequately controlled symptoms. This study sought to generate an evidence-based checklist in order to support specialist palliative care clinicians integrate care in residential nursing homes for older people.

Methods

A grounded theory ethnographic study, involving non-participant observation and qualitative interviews. The study was conducted at four residential facilities for older people in one city. Observations and recordings of 15 meetings were made, and complimented by 13 interviews with staff attending the needs rounds.

Results

The palliative care needs round checklist is presented, alongside rich description of how needs rounds are conducted. Extracts from interviews with needs rounds participants illustrate the choice of items within the checklist and their importance in supporting the evolution towards efficient and effective high-quality specialist palliative care input to the care of older people living in residential care.

Conclusions

The checklist can be used to support the integration of specialist palliative care into residential care to drive up quality care, provide staff with focused case-based education, maximise planning and reduce symptom burden for people at end of life.
Use of a 23-hour emergency department observation unit for the management of patients with toxic exposures
Authors: Mong Rupeng , Arciaga Gabriel Joseph , Tan Hock Heng
Published: August 2017

Background

A significant proportion of patients with toxic exposures presenting to the ED require admission. However, most will improve within 24 hours, and so could potentially be managed in a short-stay observation unit. We describe the management and outcomes of these patients in a 23-hour ED observation unit (EDOU).

Methods

A retrospective chart review of all patients with toxic exposures admitted to the EDOU in Singapore between 1 April 2013 and 31 March 2015 was performed. Patient demographics, exposure patterns, clinical presentation and interventions received were abstracted. The poisoning severity score (PSS) was retrospectively determined. Outcomes were length of stay and disposition.

Results

A total of 286 patients were analysed, of which 78.0% had intentional self-poisoning, 12.2% had bites/stings and 9.8% had unintentional or occupational toxic exposures. Analgesics (29.4%), sedatives (12.3%) and antidepressants (6.8%) were the most common drugs encountered. The majority of patients had a mild (68.9%) or moderate (15.4%) PSS, but 4.2% were graded as severe. Most patients with deliberate self-poisoning were reviewed by psychiatry (88.8%) and social services (74.9%). Most patients (92.0%) were medically cleared during their stay in EDOU, including all 12 with a severe PSS. Of these, 200 (69.9%) were discharged and 63 (22.0%) were transferred directly to a psychiatric unit. The median length of stay in the EDOU was 18 hours (IQR 13–23).

Conclusion

Most patients admitted to the EDOU were successfully managed and medically cleared within 23 hours, including those with a severe PSS. The EDOU appears to be a suitable alternative to inpatient admission for selected patients.
Food sources of sodium, saturated fat, and added sugar in the Physical Activity and Nutrition for Diabetes in Alberta (PANDA) trial
Authors: Asaad Ghada , Chan Catherine B.
Published: August 2017

Diabetic patients may find it difficult to achieve recommended nutrient intakes embedded within dietary guidelines. The objective of this analysis was to document total sodium, saturated fat, and added sugar intake as well as the main food sources of these nutrients in Canadian adults with type 2 diabetes before and after an intervention focused on healthy eating. Participants were enrolled in a single-arm dietary intervention trial designed to improve glycemic control and adherence to dietary recommendations. A 4-week menu plan and recipes were provided for participants along with a 6-week educational curriculum. Three repeated 24-h dietary recalls were collected at baseline and 3 months. Food sources of sodium, saturated fat, and added sugar were a secondary outcome derived from the dietary recalls. After 3 months, there was a reduction (p < 0.05) in sodium intake of 561 mg/day, which was mainly due to reduced consumption of processed meats, soups, and condiments. Significantly lower intake of processed meat contributed to –2.9 g/day saturated fat intake (p < 0.1) while added sugar intake declined by 7 g/day (p < 0.1), which was due to lower consumption of baked goods/desserts and chocolate (both p < 0.05). The intervention was beneficial for type 2 diabetes patients in terms of changing dietary habits. However, the majority of the participants still exceeded the dietary guidelines for sodium and saturated fat. In addition to the efforts of individuals and their healthcare providers, strategies to increase the nutritional quality of prepared foods could provide widespread benefits.
Major geological events in the late Guadalupian and carbon–strontium isotope responses in the Yangtze platform, South China
Authors: Shi Zejin , Yin Guan , Li Wenjie , Yang Huaixin , Zhang Jin , Lu Leixun , Tian Yaming , Wang Yong
Published: August 2017

Two sections of marine carbonate strata, Podu and Lengshuixi, from the Yangtze platform, South China, are investigated in terms of major geological events and carbon–strontium isotope responses. The results show a large-scale regression and a Large Igneous Province (LIP) event occurred in succession in the short interval of the late Guadalupian, inducing a biodiversity crisis. The regression event, marked by an increase in the 87Sr/86Sr ratio, is observed in the Jinogondolella postserrata Zone. It contributed significantly to the reduction in species habitat, leading to notable losses within the shallow-water species assemblage. A subsequent LIP event occurred after the appearance of Jinogondolella altudaensis, releasing CO2 and numerous other deleterious gases that further amplified the crisis in shallow-water to deep-sea environments. The corresponding decline in Sr and C isotopes could have been a response to the basaltic eruption (relative increase from mantle-derived Sr) and release of 12C-enriched CO2. During the process of creation of the LIP, the decline in δ13Ccarb was mainly associated with 12C-enriched CO2 release from organic matter in sedimentary strata, and high-temperature isotope fractionation during the volcanic eruption stage (exceeding 1200 °C). This study could further provide valuable clues regarding the development process of the major geological events and the causes of the biodiversity crisis.
NMDA receptors in the dorsal hippocampal area are involved in tramadol state-dependent memory of passive avoidance learning in mice
Authors: Jafari-Sabet Majid , Mofidi Hamed , Attarian-Khosroshahi Mohammad-Sadegh
Published: August 2017

The precise neurobiological mechanisms of tramadol abuse underlying the cognitive function are still unknown. The aim of the present study was to examine the possible effects of intra-CA1 injections of N-methyl-d-aspartate (NMDA), a glutamate NMDA receptor (NMDAR) agonist, and d,l-2-amino-5-phosphonopentanoic acid (DL-AP5), a competitive NMDAR antagonist, on tramadol state-dependent memory. A single-trial step-down passive avoidance task was used for the assessment of memory retrieval in adult male NMRI mice. Post-training i.p. administration of an atypical μ-opioid receptor agonist, tramadol (2.5 and 5 mg/kg), dose-dependently induced impairment of memory retention. Pre-test injection of tramadol (2.5 and 5 mg/kg) induced state-dependent retrieval of the memory acquired under post-training administration of tramadol (5 mg/kg) influence. Pre-test intra-CA1 injection of NMDA (10−5 and 10−4 μg/mouse) 5 min before the administration of tramadol (5 mg/kg, i.p.) dose-dependently inhibited tramadol state-dependent memory. Pre-test intra-CA1 injection of DL-AP5 (0.25 and 0.5 μg/mouse) reversed the memory impairment induced by post-training administration of tramadol (5 mg/kg). Pre-test administration of DL-AP5 (0.25 and 0.5 μg/mouse) with an ineffective dose of tramadol (1.25 mg/kg) restored the retrieval and induced tramadol state-dependent memory. It can be concluded that dorsal hippocampal NMDAR mechanisms play an important role in the modulation of tramadol state-dependent memory.
Casimir effect for the Higgs field at finite temperature
Authors: Santos A. F. , Khanna Faqir C.
Published: August 2017

In early 1970, it was postulated that there exists a zero spin quantum field, called Higgs field, that is present in all universe. The potential energy of the Higgs field is transferred to particles. Hence they acquire mass. These ideas were essential in fulfilling the basic need for a particle, called Higgs, with mass. These particles are called Higgs particles with spin zero with its mass to be [Formula: see text][Formula: see text]125 GeV. This raises the question as to its physical effects. If these particles are present, will they exhibit a Casimir effect and also obey the Stefan–Boltzmann Law? Assuming the dynamics of this field, will these effects change with temperature. The present calculation uses thermo field dynamics formalism to calculate temperature effects.
Improvement in Depth of Return Loss of Microstrip Antenna for S-Band Applications
Authors: Khinda Jaspal Singh , Tripathy Malay Ranjan , Gambhir Deepak
Published: August 2017

For S-band applications, a microstrip fractal antenna is designed by extending narrow impedance bandwidth into wide impedance bandwidth with use of partial ground plane. In the designed fractal antenna, the six elliptical slots in ground plane and two elliptical slots in radiating patch are embedded to improve the depth of return loss. Further, the parametric study is performed on width of microstrip feeding line, position/size of ellipses in radiating patch and ground plane to achieve mismatch loss [Formula: see text] 0.044[Formula: see text]dB and power delivered to antenna 99%, i.e., return loss [Formula: see text][Formula: see text]dB for S-band. The simulated antenna results are obtained using electromagnetic solver software and fabricated antenna results are measured using Vector Network Analyzer Bench MS46322A and they are found to be in good agreement.
Implications of a frame dependent gravitational effective action for perturbations on the Robertson–Walker metric
Authors: Adler Stephen L.
Published: August 2017

In earlier work we showed that a frame dependent effective action motivated by the postulates of three-space general coordinate invariance and Weyl scaling invariance exactly mimics a cosmological constant in Robertson–Walker (RW) spacetimes. Here we study the implications of this effective action for small fluctuations around a spatially flat RW background geometry. The equations for the conserving extension of the modified stress-energy tensor can be integrated in closed form, and involve only the metric perturbation [Formula: see text]. Hence the equations for tensor and vector perturbations are unmodified, but there are Hubble scale additions to the scalar perturbation equations, which nonetheless admit no propagating wave solutions. Consequently, there are no modifications to standard gravitational wave propagation theory, but there may be observable implications for cosmology. We give a self-contained discussion, including an analysis of the restricted class of gauge transformations that act when a frame dependent effective action is present.
A solution to lithium problem by long-lived stau
Authors: Sato Joe , Shimomura Takashi , Yamanaka Masato
Published: August 2017

We review a nonstandard Big-Bang Nucleosynthesis (BBN) scenario within the minimal supersymmetric standard model, and propose an idea to solve both the [Formula: see text] and [Formula: see text] problems. Each problem is a discrepancy between the predicted abundance in the standard BBN and observed one. We focus on the stau, a supersymmetric partner of tau lepton, which is a long-lived charged particle when it is the next lightest supersymmetric particle and is degenerate in mass with the lightest supersymmetric particle. The long-lived stau forms a bound state with a nucleus, and provides nonstandard nuclear reactions. One of those, the internal conversion process, accelerates the destruction of [Formula: see text] and [Formula: see text], and leads to a solution to the [Formula: see text] problem. On the other hand, the bound state of the stau and [Formula: see text] enhances productions of n, D, T and [Formula: see text]. The over-production of [Formula: see text] could solve the [Formula: see text] problem; while the over-productions of D and T could conflict with observations, and hence the relevant parameter space of the stau is strictly constrained. We therefore need to carefully investigate the stau–[Formula: see text] bound state to find a condition of solving the [Formula: see text] problem. The scenario of the long-lived stau simultaneously and successfully fits the abundances of light elements (D, T, [Formula: see text], [Formula: see text], [Formula: see text] and [Formula: see text]) and the neutralino dark matter to the observed ones. Consequently, the parameter space both of the stau and the neutralino is determined with excellent accuracy.
How Do Patents Affect Research Investments?
Authors: Williams Heidi L.
Published: August 2017

Although patent systems have been widely used both historically and internationally, there is nonetheless a tremendous amount of controversy over whether patent systems, in practice, improve the alignment between private returns and social contributions. In this article, I describe three parameters—how the disclosure function affects research investments, how patent strength affects research investments in new technologies, and how patents on existing technologies affect follow-on innovation—needed to inform the question of how patents affect research investments, and review the available evidence that has attempted to empirically estimate these parameters.
Catastrophic Epilepsies of Childhood
Authors: Howard MacKenzie A. , Baraban Scott C.
Published: August 2017

The tragedy of epilepsy emerges from the combination of its high prevalence, impact upon sufferers and their families, and unpredictability. Childhood epilepsies are frequently severe, presenting in infancy with pharmaco-resistant seizures; are often accompanied by debilitating neuropsychiatric and systemic comorbidities; and carry a grave risk of mortality. Here, we review the most current basic science and translational research findings on several of the most catastrophic forms of pediatric epilepsy. We focus largely on genetic epilepsies and the research that is discovering the mechanisms linking disease genes to epilepsy syndromes. We also describe the strides made toward developing novel pharmacological and interventional treatment strategies to treat these disorders. The research reviewed provides hope for a complete understanding of, and eventual cure for, these childhood epilepsy syndromes.
The Role of the Lateral Intraparietal Area in (the Study of) Decision Making
Authors: Huk Alexander C. , Katz Leor N. , Yates Jacob L.
Published: August 2017

Over the past two decades, neurophysiological responses in the lateral intraparietal area (LIP) have received extensive study for insight into decision making. In a parallel manner, inferred cognitive processes have enriched interpretations of LIP activity. Because of this bidirectional interplay between physiology and cognition, LIP has served as fertile ground for developing quantitative models that link neural activity with decision making. These models stand as some of the most important frameworks for linking brain and mind, and they are now mature enough to be evaluated in finer detail and integrated with other lines of investigation of LIP function. Here, we focus on the relationship between LIP responses and known sensory and motor events in perceptual decision-making tasks, as assessed by correlative and causal methods. The resulting sensorimotor-focused approach offers an account of LIP activity as a multiplexed amalgam of sensory, cognitive, and motor-related activity, with a complex and often indirect relationship to decision processes. Our data-driven focus on multiplexing (and de-multiplexing) of various response components can complement decision-focused models and provides more detailed insight into how neural signals might relate to cognitive processes such as decision making.
Overactivation of intestinal sterol response element-binding protein 2 promotes diet-induced nonalcoholic steatohepatitis
Authors: Malhotra Pooja , Aloman Costica , Ankireddy Aparna , Khadra Hani , Ooka Kohtaro , Gill Ravinder K. , Saksena Seema , Dudeja Pradeep K. , Alrefai Waddah A.
Published: August 2017

Nonalcoholic fatty liver disease (NAFLD) is characterized by lipid accumulation in the liver that may progress to hepatic fibrosis and nonalcoholic steatohepatitis (NASH). Mechanisms underlying NAFLD and NASH are not yet fully understood. Dietary cholesterol was recently shown to be a risk factor for the development of NASH, suggesting a role for intestinal handling of cholesterol. One important regulator of cholesterol homeostasis is the sterol response element-binding protein-2 (SREBP-2) transcription factor. We tested the hypothesis that the overactivation of intestinal SREBP-2 increases the susceptibility to diet-induced NASH. A transgenic mouse model with intestine-specific overexpression of active SREBP-2 (ISR2 mice) driven by villin promoter was used. ISR2 mice and their wild-type littermates were fed a regular chow diet or a high-fat, high-cholesterol (HFHC) diet (15% fat, 1% cholesterol) for 15 wk. Results showed that HFHC feeding to ISR2 mice caused hepatic inflammation with increased levels of proinflammatory cytokines. Histological examination demonstrated extensive fibrosis after a HFHC diet associated with a perivascular as well as pericellular collagen deposits in ISR2 mice compared with wild-type littermates. The severe hepatic inflammation and advanced fibrosis in ISR2 mice was not associated with a difference in lipid accumulation in ISR2 mice compared with wild type littermates after HFHC feeding. These data indicate that overactivation of intestinal SREBP2 promotes diet-induced hepatic inflammation with features of human NASH resulting in rapid severe fibrosis and provide a novel link between regulatory processes of intestinal cholesterol and progression of fatty liver.

NEW & NOTEWORTHY The current study highlights the role of overactivation of intestinal SREBP-2 transcription factor in the progression of hepatic fibrosis associated with diet-induced NASH. Mice with intestine-specific overexpression of SREBP-2 demonstrated more inflammation and severe fibrosis in the liver in response to 15 wk of being fed a high-cholesterol, high-fat diet as compared with their wild-type littermates. These data demonstrate a novel link between intestinal regulatory processes of cholesterol metabolism and the pathogenesis of fatty liver diseases.
Regulation of energy metabolism during social interactions in rainbow trout: a role for AMP-activated protein kinase
Authors: Gilmour K. M. , Craig P. M. , Dhillon R. S. , Lau G. Y. , Richards J. G.
Published: August 2017

Rainbow trout ( Oncorhynchus mykiss) confined in pairs form social hierarchies in which subordinate fish typically experience fasting and high circulating cortisol levels, resulting in low growth rates. The present study investigated the role of AMP-activated protein kinase (AMPK) in mediating metabolic adjustments associated with social status in rainbow trout. After 3 days of social interaction, liver AMPK activity was significantly higher in subordinate than dominant or sham (fish handled in the same fashion as paired fish but held individually) trout. Elevated liver AMPK activity in subordinate fish likely reflected a significantly higher ratio of phosphorylated AMPK (phospho-AMPK) to total AMPK protein, which was accompanied by significantly higher AMPKα1relative mRNA abundance. Liver ATP and creatine phosphate concentrations in subordinate fish also were elevated, perhaps as a result of AMPK activity. Sham fish that were fasted for 3 days exhibited effects parallel to those of subordinate fish, suggesting that low food intake was an important trigger of elevated AMPK activity in subordinate fish. Effects on white muscle appeared to be influenced by the physical activity associated with social interaction. Overall, muscle AMPK activity was significantly higher in dominant and subordinate than sham fish. The ratio of phospho-AMPK to total AMPK protein in muscle was highest in subordinate fish, while muscle AMPKα1relative mRNA abundance was elevated by social dominance. Muscle ATP and creatine phosphate concentrations were high in dominant and subordinate fish at 6 h of interaction and decreased significantly thereafter. Collectively, the findings of the present study support a role for AMPK in mediating liver and white muscle metabolic adjustments associated with social hierarchy formation in rainbow trout.
The interplay between iron and oxygen homeostasis with a particular focus on the heart
Authors: Lakhal-Littleton Samira , Robbins Peter Alistair
Published: August 2017

Iron is subject to tight homeostatic control in mammals. At the systemic level, iron homeostasis is controlled by the liver-derived hormone hepcidin acting on its target ferroportin in the gut, spleen, and liver, which form the sites of iron uptake, recycling, and storage, respectively. At the cellular level, iron homeostasis is dependent on the iron regulatory proteins IRP1/IRP2. Unique chemical properties of iron underpin its importance in biochemical reactions involving oxygen. As such, it is not surprising that there are reciprocal regulatory links between iron and oxygen homeostasis, operating both at the systemic and cellular levels. Hypoxia activates the IRP pathway, and in addition suppresses liver hepcidin through endocrine factors that have yet to be fully elucidated. This review summarizes current knowledge on the interplay between oxygen and iron homeostasis and describes recent insights gained into this interaction in the context of the heart. These include the recognition that the hepcidin/ferroportin axis plays a vital role in the regulation of intracellular iron homeostasis as well as regulating systemic iron availability. As is the case for other aspects of iron homeostasis, hypoxia significantly modulates the function of the hepcidin/ferroportin pathway in the heart. Key areas still to understand are the interactions between cardiac iron and diseases of the heart where hypoxia is a recognized component.
Hemoperitoneum Secondary to Spontaneous Rupture of a Retroperitoneal Varix
Authors: Eichele Derrick D.
Published: August 2017

Hemoperitoneum due to a ruptured retroperitoneal varix is an exceedingly rare condition and a poor prognostic sign with catastrophic and life-threatening complication of portal hypertension. We present a unique case of a 56-year-old female with cirrhosis secondary to primary sclerosing cholangitis who presented with acute abdominal pain and hypovolemic shock prior to a cardiac arrest following a ruptured retroperitoneal varix without prior esophageal varices and a newly identified intrahepatic cholangiocarcinoma. The clinical presentation with abdominal pain and hemorrhagic shock is consistently reported in the relevant literature. Early recognition affords appropriate management and urgent surgical intervention leading to survival.
A Hypothalamic Leptin-Glutamate Interaction in the Regulation of Sympathetic Nerve Activity
Authors: Zheng Hong , Liu Xuefei , Li Yulong , Patel Kaushik P.
Published: August 2017

Accumulated evidence indicates that obesity-induced type 2 diabetes (T2D) is associated with enhanced sympathetic activation. The present study was conducted to investigate the role for leptin-glutamate signaling within the hypothalamus in regulating sympathetic nerve activity. In anesthetized rats, microinjections of leptin (5 ng ~ 100 ng) into the arcuate nucleus (ARCN) and paraventricular nucleus (PVN) induced increases in renal sympathetic nerve activity (RSNA), blood pressure (BP), and heart rate (HR). Prior microinjections of NMDA receptor antagonist AP5 (16 pmol) into the ARCN or PVN reduced leptin-induced increases in RSNA, BP, and HR in both ARCN and PVN. Knockdown of a leptin receptor with siRNA inhibited NMDA-induced increases in RSNA, BP, and HR in the ARCN but not in the PVN. Confocal calcium imaging in the neuronal NG108 and astrocytic C6 cells demonstrated that preincubation with leptin induced an increase in intracellular calcium green fluorescence when the cells were challenged with glutamate. In high-fat diet and low-dose streptozotocin-induced T2D rats, we found that leptin receptor and NMDA NR1receptor expressions in the ARCN and PVN were significantly increased. In conclusion, these studies provide evidence that within the hypothalamic nuclei, leptin-glutamate signaling regulates the sympathetic activation. This may contribute to the sympathoexcitation commonly observed in obesity-related T2D.
Enhanced Expression of IL-18 and IL-18BP in Plasma of Patients with Eczema: Altered Expression of IL-18BP and IL-18 Receptor on Mast Cells
Authors: Hu Yalin , Wang Junling , Zhang Huiyun , Xie Hua , Song Weiwei , Jiang Qijun , Zhao Nan , He Shaoheng
Published: August 2017

IL-18 has been found to be associated with eczema. However, little is known of the role of IL-18 binding protein (BP) and IL-18 receptor (R) in eczema. We therefore investigated the expression of IL-18, IL-18BP, and IL-18R on mast cells by using flow cytometry analysis and mouse eczema model. The results showed that plasma free IL-18 and free IL-18BP levels in eczema patients were higher than those in healthy controls. IL-18 provoked up to 3.1-fold increase in skin mast cells. IL-18 induced also an increase in IL-18BP+ mast cells, but a reduction of IL-18R+ mast cells in mouse eczema skin. It was found that house dust mite allergen Der p1 and egg allergen OVA induced upregulation of the expression of IL-18, IL-18BP, and IL-18R mRNAs in HMC-1 cells following 2 and 16 h incubation. In conclusion, correlation of IL-18 and IL-18BP in eczema plasma suggests an important balance between IL-18 and IL-18BP in eczema. The decrease in molar concentration ratio of plasma IL-18BP/IL-18 and allergen-induced upregulated expression of IL-18 and IL-18R in skin mast cells of the patients with eczema suggests that anti-IL-18 including IL-18BP therapy may be useful for the treatment of eczema.
White Matter Hyperintensity Load Modulates Brain Morphometry and Brain Connectivity in Healthy Adults: A Neuroplastic Mechanism?
Authors: De Marco Matteo , Manca Riccardo , Mitolo Micaela , Venneri Annalena
Published: August 2017

White matter hyperintensities (WMHs) are acquired lesions that accumulate and disrupt neuron-to-neuron connectivity. We tested the associations between WMH load and (1) regional grey matter volumes and (2) functional connectivity of resting-state networks, in a sample of 51 healthy adults. Specifically, we focused on the positive associations (more damage, more volume/connectivity) to investigate a potential route of adaptive plasticity. WMHs were quantified with an automated procedure. Voxel-based morphometry was carried out to model grey matter. An independent component analysis was run to extract the anterior and posterior default-mode network, the salience network, the left and right frontoparietal networks, and the visual network. Each model was corrected for age, global levels of atrophy, and indices of brain and cognitive reserve. Positive associations were found with morphometry and functional connectivity of the anterior default-mode network and salience network. Within the anterior default-mode network, an association was found in the left mediotemporal-limbic complex. Within the salience network, an association was found in the right parietal cortex. The findings support the suggestion that, even in the absence of overt disease, the brain actuates a compensatory (neuroplastic) response to the accumulation of WMH, leading to increases in regional grey matter and modified functional connectivity.
An Acquisition Algorithm with NCCFR for BOC Modulated Signals
Authors: Feng Yongxin , Liu Fang , Yao Xudong , Zhang Xiaoyu
Published: August 2017

With the development of satellite navigation technology, BOC (Binary Offset Carrier) signals are proposed and applied in navigation system. However, in the advantages of enhancing the utilized rating of the band resource, some new problems are also emerging in the acquisition processing. On the basis of analyzing the limitations of the existing methods in suppressing side peaks, a NCCFR (New Cross-Correlation Function Reconstruction) algorithm is proposed, in which different modulation coefficients are used to construct correlation function with a shifter phase. The simulation results show that the new algorithm can suppress first side peaks and restrain other side peaks.
Split-Hand Malformation in a 4-Year-Old Child
Authors: Meshram Girish Gulab , Hura Kanwaljeet Singh , Kaur Neeraj
Published: August 2017

Split-hand deformity is one of the milder manifestations of a congenital disorder called split-hand/split-foot malformation. We present a case of a 4-year-old child with split-hand malformation in his left hand since birth. A median cleft was present in the affected hand with absence of the 3rd and 4th digits, giving rise to a characteristic lobster-claw appearance. Functionality of the affected hand was modestly impaired. As none of the close family members of the patient had similar limb malformations, the deformity was postulated to arise most likely from a de novo mutation. The patient was discharged after the parents were provided with genetic counseling.
Autologous Stem Cells Combined Core Decompression for Treatment of Avascular Necrosis of the Femoral Head: A Systematic Meta-Analysis
Authors: Xu Shibing , Zhang Lei , Jin Hongting , Shan Letian , Zhou Li , Xiao Luwei , Tong Peijian
Published: August 2017

Objective. This study aims to systematically evaluate the efficacy and safety of core decompression combined transplantation of autologous bone marrow stem cells (CDBMSCs) for treatment of avascular necrosis of the femoral head (ANFH). Methods. Randomized controlled trials (RCTs) regarding effectiveness of core decompression combined transplantation of autologous bone marrow stem cells for treating ANFH were searched in 8 comprehensive databases prior to September 2016. The data analysis was performed by using the RevMan version 5.3. Results. A total of 11 studies with 507 participants were included. Results showed that CDBMSCs group was more effective than CD group in increasing Harris hip score, decreasing necrotic area of femoral head, collapse of femoral head, and conversion to total hip replacement incidence. In the subgroup analysis, the results did not change in different intervention measure substantially. In addition, the safety of CDBMSCs for ANFH is reliable. Conclusion. Based on the systematic review, our findings suggest that core decompression combined transplantation of autologous bone marrow stem cells appeared to be more efficacious in the treatment at early stages of ANFH.
Secure and Privacy-Preserving Data Sharing and Collaboration in Mobile Healthcare Social Networks of Smart Cities
Authors: Huang Qinlong , Wang Licheng , Yang Yixian
Published: August 2017

Mobile healthcare social networks (MHSN) integrated with connected medical sensors and cloud-based health data storage provide preventive and curative health services in smart cities. The fusion of social data together with real-time health data facilitates a novel paradigm of healthcare big data analysis. However, the collaboration of healthcare and social network service providers may pose a series of security and privacy issues. In this paper, we propose a secure health and social data sharing and collaboration scheme in MHSN. To preserve the data privacy, we realize secure and fine-grained health data and social data sharing with attribute-based encryption and identity-based broadcast encryption techniques, respectively, which allows patients to share their private personal data securely. In order to achieve enhanced data collaboration, we allow the healthcare analyzers to access both the reencrypted health data and the social data with authorization from the data owner based on proxy reencryption. Specifically, most of the health data encryption and decryption computations are outsourced from resource-constrained mobile devices to a health cloud, and the decryption of the healthcare analyzer incurs a low cost. The security and performance analysis results show the security and efficiency of our scheme.
Small-Scale Flat Plate Collectors for Solar Thermal Scavenging in Low Conductivity Environments
Authors: Ogbonnaya Emmanuel , Weiss Leland
Published: August 2017

There is great opportunity to develop power supplies for autonomous application on the small scale. For example, remote environmental sensors may be powered through the harvesting of ambient thermal energy and heating of a thermoelectric generator. This work investigates a small-scale (centimeters) solar thermal collector designed for this application. The absorber is coated with a unique selective coating and then studied in a low pressure environment to increase performance. A numerical model that is used to predict the performance of the collector plate is developed. This is validated based on benchtop testing of a fabricated collector plate in a low-pressure enclosure. Model results indicate that simulated solar input of about 800 W/m2 results in a collector plate temperature of 298 K in ambient conditions and up to 388 K in vacuum. The model also predicts the various losses in W/m2 K from the plate to the surroundings. Plate temperature is validated through the experimental work showing that the model is useful to the future design of these small-scale solar thermal energy collectors.
Outcomes of Vitrectomy in Pediatric Retinal Detachment with Proliferative Vitreoretinopathy
Authors: Rejdak Robert , Nowakowska Dominika , Wrona Katarzyna , Maciejewski Ryszard , Junemann Anselm G. , Nowomiejska Katarzyna
Published: August 2017

Aim. To report outcomes of pars plana vitrectomy (PPV) in pediatric retinal detachment (RD) with proliferative vitreoretinopathy (PVR), complications, factors influencing the final anatomical and functional results. Methods. Retrospective consecutive case series of 14 eyes. Average postoperative follow-up period was 34 months. Results. Mean age of patients was 10 years; eleven patients (79%) were males. The most common etiology was trauma (57%), the second—myopia (36%) and one case of uveitis (7%). At the day of presentation, the best-corrected visual acuity (BCVA) was worse than hand motion (50%); macula was detached in 86% of cases. Simultaneous PPV and phacoemulsification with intraocular lens (IOL) implantation were performed in 12 cases (86%). The most common endotamponade during PPV was silicone oil (93%). Anatomic reattachment was accomplished in 86% of cases. Final BCVA was equal or better than 0.1 in 50% of patients. The postoperative complications were found in 5 eyes (36%). Conclusion. Complete PPV was allowed for anatomically reattached retina and preserved vision in pediatric complex RD with PVR. However, visual outcomes were not satisfactory. Preserving vision in children with RD is of great importance for their future motor and intellectual development. This trial is registered with ClinicalTrials.gov Identifier: NCT03208205.
Design of Optically Transparent Antenna with Directional Radiation Patterns
Authors: Yao Yuan , Chen Wanzhong , Chen Xiaodong , Yu Junsheng
Published: August 2017

An optically transparent antenna with directional radiation pattern is proposed in this paper. This antenna consists of a radiation patch above the transparent glass substrate and a frequency selective surface acting as the ground of microstrip antenna on the back of the glass. The frequency selective surface (FSS) performs well as ground in the working frequency range to achieve directional radiation pattern. A SMA connector is used to feed the antenna. The antenna can operate at the on-board dedicated short-range communication band from 5.725 GHz to 5.85 GHz. Simulations and measurements are carried out to study the antenna performances in terms of impedance matching, gain, and radiation patterns. Both of the simulation and measurement results are shown to illustrate the good performance of the proposed antenna. It is very suitable for car network communication scene.
Facile Synthesis, Microstructure, and Gas Sensing Properties of NdCoO3 Nanoparticles
Authors: Gildo-Ortiz Lorenzo , Guillén-Bonilla Héctor , Reyes-Gómez Juan , Rodríguez-Betancourtt Verónica María , Olvera-Amador M. de la L. , Eguía-Eguía Sandra Irene , Guillén-Bonilla Alex , Santoyo-Salazar Jaime
Published: August 2017

NdCoO3 nanoparticles were successfully synthesized by a simple, inexpensive, and reproducible solution method for gas sensing applications. Cobalt nitrate, neodymium nitrate, and ethylenediamine were used as precursors and distilled water as solvent. The solvent was evaporated later by means of noncontinuous microwave radiation at 290 W. The obtained precursor powders were calcined at 200, 500, 600, and 700°C in a standard atmosphere. The oxide crystallized in an orthorhombic crystal system with space group Pnma (62) and cell parameters a=5.33 Å, b=7.52 Å, and c=5.34 Å. The nanoparticles showed a diffusional growth to form a network-like structure and porous adsorption configuration. Pellets prepared from NdCoO3 were tested as gas sensors in atmospheres of carbon monoxide and propane at different temperatures. The oxide nanoparticles were clearly sensitive to changes in gas concentrations (0–300 ppm). The sensitivity increased with increasing concentration of the gases and operating temperatures (25, 100, 200, and 300°C).
PPAR‐γ Activation Prevents Septic Cardiac Dysfunction via Inhibition of Apoptosis and Necroptosis
Authors: Peng Shiyan , Xu Junmei , Ruan Wei , Li Suobei , Xiao Feng
Published: August 2017

Sepsis‐induced cardiac dysfunction remains one of the major causes of death in intensive care units. Overwhelmed inflammatory response and unrestrained cell death play critical roles in sepsis‐induced cardiac dysfunction. Peroxisome proliferator‐activated receptor‐ (PPAR‐) γ has been proven to be cardioprotective in sepsis. However, the mechanism of PPAR‐γ‐mediated cardioprotection and its relationship with inflammation and cell death are unclear. We hypothesized that activation of PPAR‐γ by reducing cardiac inflammation, myocardial apoptosis, and necroptosis may prevent myocardial dysfunction in sepsis. Rats were subjected to cecal ligation and puncture (CLP) with or without PPAR‐γ agonist (rosiglitazone) or antagonist T0070907 (T007). After CLP, cardiac function was significantly depressed, which was associated with the destructed myocardium, upregulated proinflammatory cytokines, and increased apoptosis, necrosis, and necroptosis. This process is corresponded with decreased inhibitor κB (IκBα) and increased NF‐κB, receptor‐interacting protein kinase‐1 (RIP1), RIP3, and mixed lineage kinase‐like (MLKL) protein. Activation of PPAR‐γ by rosiglitazone pretreatment enhanced PPAR‐γ activity and prevented these changes, thereby improving the survival of septic rats. In contrast, inhibition of PPAR‐γ by T007 further exacerbated the condition, dropping the survival rate to nearly 0%. In conclusion, PPAR‐γ activation by reducing proinflammatory cytokines, apoptosis, and necroptosis in the myocardium prevents septic myocardial dysfunction.
Leaf Senescence, Root Morphology, and Seed Yield of Winter Oilseed Rape (Brassica napus L.) at Varying Plant Densities
Authors: Li Ming , Naeem Muhammad Shahbaz , Ali Shafaqat , Zhang Liyan , Liu Lixin , Ma Ni , Zhang Chunlei
Published: August 2017

In this study, the yield and yield components were studied using a conventional variety Zhongshuang 11 (ZS 11) and a hybrid variety Zhongyouza 12 (ZYZ 12) at varying plant densities. The increase in plant density led to an initial increase in seed yield and pod numbers per unit area, followed by a decrease. The optimal plant density was 58.5 × 104 plants ha−1 in both ZS 11 and ZYZ 12. The further researches on physiological traits showed a rapid decrease in the green leaf area index (GLAI) and chlorophyll content and a remarkable increase in malondialdehyde content in high plant density (HPD) population than did the low plant density (LPD) population, which indicated the rapid leaf senescence. However, HPD had higher values in terms of pod area index (PAI), pod photosynthesis, and radiation use efficiency (RUE) after peak anthesis. A significantly higher level of dry matter accumulation and nitrogen utilization efficiency were observed, which resulted in higher yield. HPD resulted in a rapid decrease in root morphological parameters (root length, root tips, root surface area, and root volume). These results suggested that increasing the plant density within a certain range was a promising option for high seed yield in winter rapeseed in China.
Swollen Optic Disc and Sinusitis
Authors: Del Noce Chiara , Marchi Filippo , Sollini Giacomo , Iester Michele
Published: August 2017

Purpose: To present a case of optic disc swelling caused by sinusitis. Methods: Ocular symptoms were investigated using computed tomography imaging of the facial bones to detect the relationship between the sinus inflammation and the optic nerve. Results: A particular configuration of the optic nerve was detected. Optic nerve course through the inflamed sphenoidal sinus is a condition associated with a greater risk of inflammation. Conclusion: Sinusitis is a rare but treatable cause of optic neuritis. The choice of the correct radiological investigation to be done to set up a proper treatment of the sinus pathological condition is also essential for the resolution of ocular symptoms.