bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrating Freshman STEM Education into a Big-History Course in Japan
Authors:   Symbiosis School for Liberal Arts, Symbiosis International University, Robert Martin
Published: June 2023

Undergraduate education for Science, Technology, Engineering and Mathematics (STEM) has been a global priority of governments for decades, because of its direct connection to work-force development in a world with growing dependence on technology and information. Technology is the outcome of an evolutionary process leading to increases of complexity and emergence of new functionalities, which is a central theme in Big History. In modern Japan, large public universities focus on undergraduate STEM education, originally inspired by the American model. This Japanese STEM approach is rather heavily based on liberal arts and general education courses that are taught as distinct silos in mathematics, physics, chemistry, biology, etc. At least, this is the case for most of the first-year and some of the second-year content in most four-year degree programs. This model has its benefits and provides a solid foundation in these disciplines, one that expands on high school experience. However, this often means that students tend to overlook or forget the deep connections between disciplines.
Education in a Playful Universe
Authors:   Department of Interreligious Studies, St. Xavier’s College, Mumbai, India, Olalekar Prashant
Published: June 2023

The 13th century Sufi poet Muhammad Rumi [جلال‌الدین محمد رومی] vividly incorporates the image of dance and movement in his lyrics, while the Mehlevi Order of Sufi Islam (popularly known as ‘Whirling Dervishes’) was founded on Rumi’s teachings. Such expressions of emotive joy were among the favourites of my students, when I served as Director of Inter-Religious Studies at St. Xavier’s College in Mumbai. The testimony of a college student in our Honours course, ‘Awakening to Cosmic Compassion,’ gives an idea of the impact that movement and embodied meditation makes on learning.
O crime da Última Hora: Porto Alegre na passagem dos anos cinquenta
Authors: Pereira Elmir Cláudio
Published: June 2023

É com grande emoção que publicamos o trabalho de Cláudio Pereira Elmir intitulado O Crime da Última Hora: Porto Alegre na Passagem dos Anos Cinquenta para compor a Coleção Historiográfica Sul-Rio-Grandense. Defendida como uma dissertação de Mestrado no Programa de Pós-Graduação em História da Universidade Federal do Rio Grande do Sul (UFRGS) em agosto de 1996, a obra é uma importante contribuição historiográfica para os estudos sobre crime no contexto regional, sendo que ainda não havia se tornado um livro ou mesmo contato com disponibilização digital. Desta forma, espera-se que sua publicação em formato e-book seja uma renovação dos esforços do autor em disseminar o conhecimento histórico, repercutindo entre novos pesquisadores e interessados no tema. A publicação é uma homenagem ao historiador, professor e pesquisador comprometido e de marcante trajetória, que nos deixou precocemente em maio de 2020. Natural de Porto Alegre, Cláudio Elmir formou-se em História pela UFRGS no ano de 1988, obtendo posteriormente na mesma instituição o mestrado em 1996 e o doutorado em 2003. Sua tese ganhou notoriedade por revisitar a série de crimes da Rua do Arvoredo, que ocorreu em Porto Alegre entre anos de 1863 e 1864, discutindo os processos de reapropriações que se deram ao longo do tempo, incluindo uma "crítica historiográfica radical" sobre a narrativa de Décio Freitas, autor de uma popular obra sobre o tema. Publicada em livro, foi premiada com o Prêmio Açorianos de Literatura, na categoria Ensaio de Humanidades, em 2005.
Relações entre Carl Rogers e a fenomenologia: investigações históricas e epistemológicas
Authors: Coelho Castelo Branco Paulo
Published: June 2023

A Psicologia Humanista de Carl Rogers apresenta um fértil e complexo legado que congrega diversas influências psicológicas, filosóficas e psicoterapéuticas. Em especial, os aportes da Fenomenologia são enfatizados no Brasil, ao passo que é comum associar a abordagem rogeriana como uma perspectiva fenomenológica. Partindo de variados questionamentos sobre isso, este livro aborda o que Rogers citou, referiu e mencionou sobre autores e termos relacionados ao pensamento fenomenológico para situar, contextualizar e ponderar a sua relação com a Fenomenologia. Segundo critérios historiográficos e epistemológicos, foram desenvolvidos cinco estudos que investigam qual é o tipo de Fenomenologia que Rogers deparou no ceme da constituição do seu pensamento nos Estados Unidos da América. Além disso, discute algumas tensões presentes na aproximação de Rogers com a Fenomenologia, no Brasil, a partir de pontos relacionados: ao estatuto da experiência consciente no pragmatismo rogeriano e na filosofia husserliana; ao entendimento da consideração positiva incondicional como uma atitude de suspensão fenomenológica; à compreensão empática com uma via de acesso a subjetividade alheia à luz da Fenomenologia Social de Schütz. Paulo Coelho Castelo Branco é docente do Programa de Pós-Graduação (Mestrado e Doutorado) em Psicologia da Universidade Federal do Ceará, onde coordena o Núcleo de Estudos em Psicologia Humanista (NEPH). É bolsista produtividade do Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Dedica-se a estudos sobre Epistemologia, História e Clínica da Psicologia Humanista em seus desenvolvimentos matriciais nos EUA e locais no Brasil.
An Analysis on Radiation Protection Abilities of Different Colored Obsidians
Authors: AYGUN Zeynep , AYGÜN Murat
Published: June 2023

Obsidians are naturally occurring structures which have great interest and are widely used in engineering, nuclear and medical applications. These glassy volcanic rocks are formed as a result of volcanic activity and lava eruptions. In the present study, it is aimed to determine the radiation protection parameters of obsidians with different colors in order to examine the radiation shielding capabilities of the samples. The parameters were determined in the range of 4keV-100 GeV photon energies by using Phy-X/PSD code. In order to make a meaningful analyze for the radiation shielding potentials of the obsidians, the calculated mass attenuation and linear attenuation coefficients were compared with ordinary concrete which can be widely used as shielding material in the nuclear application.
A EFETIVIDADE DOS DIREITOS FUNDAMENTAIS EM TEMPOS DE CRISE: UMA ANÁLISE A PARTIR DA TEORIA DO PÊNDULO ECONÔMICO- HERMENÊUTICO
Authors: Ruas Abreu Areal Marques Pedro Henrique , Teixeira Oliveira Ruas Ana Carolina
Published: June 2023

O presente estudo tem o objetivo de elucidar a questão dos direitos fundamentais em períodos de crise, onde são comumente mitigados sob as justificativas de problemas de efetividade, como a escassez de recursos. Assim, propõe-se a análise de tais enunciados sob o óbice da obra Teoria do Pêndulo Econômico-Hermenêutico de Cláudio Carneiro Bezerra Pinto Coelho, que propõe a busca de uma resposta concreta à efetivação dos direitos fundamentais. Assim, o estudo abordará aspectos gerais sobre os direitos fundamentais. E analisará, também, os elementos que demonstram como entraves à efetivação dos direitos fundamentais. E por fim, abordará a Teoria do Pêndulo Econômico-Hermenêutico e os seus contributos para análise dos direitos fundamentais em situações de crise. Conclui-se que, tal teoria é de grande importância a concretização dos direitos fundamentais, já que propõe uma resposta correta de caráter prático-teórico por meio da pergunta adequada, propondo assim uma justiça possível. Para tanto, utilizou-se o método fenomenológico e a pesquisa bibliográfica.
O EIXO ESTATÍSTICA NOS ANOS INICIAIS DO ENSINO FUNDAMENTAL: PERSPECTIVAS A PARTIR DA PEDAGOGIA HISTÓRICO-CRÍTICA
Authors: Da Silva Araújo Adriana Jerônimo , Nozella Gama Carolina
Published: June 2023

Este artigo é resultado da nossa pesquisa de mestrado que analisou o eixo estatística na coleção do livro didático Buriti Mais Matemática (2017) para os anos iniciais do Ensino Fundamental.  Apresentamos neste momento um recorte da dissertação, visando discutir as contribuições do ensino de estatística nos anos iniciais do Ensino Fundamental, a partir da concepção pedagógica histórica-crítica.O trabalho bibliográfico valeu-se dos estudos de  Cazorla et al. (2017); CAZORLA (2002); CAZORLA e CASTRO (2008); ORSO (2021); GALVÃO, LAVOURA, MARTINS (2019); GIARDINETTO (2012); CASCAVEL (2008), etc. Concluímos que o ensino de estatística não deve estar restrito a fórmulas matemáticas e a níveis de leitura, mas, deve contribuir para a transformação social. Nessa perspectiva, é preciso superar a ideia de que não é qualquer conteúdo que fará com que o estudante se desenvolva nas suas máximas possibilidades, pois só os conhecimentos ricos em oportunidades de desenvolvimento podem de alguma maneira ampliar a formação do indivíduo em sua forma mais elaborada.
O PLURAL, O POLIFÔNICO E O VISCERAL NA OBRA CATÁRTICA DE JOHN BARROS
Authors: Silva Santos Gledinelio
Published: June 2023

A presente resenha trata do livro “Catarse: um manifesto poético”, de John Barros. Na obra em questão, o autor nos apresenta poemas que passeiam por diversos temas, ora tecendo seus versos num tom intimista, ora num tom mais crítico e direto. Por se tratar de uma obra poética, os aspectos formais e estilísticos aqui apresentados se encontrarão em segunda ordem, privilegiando a profundidade das imagens construídas pelo poeta e dinâmicas impostas por seu eu lírico.
UMA PROVOCAÇÃO À SOCIOLOGIA FRENTE À BNCC
Authors: Birkner Walter
Published: June 2023

Este ensaio é uma crítica à Sociologia contemporânea no Brasil. O ponto de partida é uma revisão de manuais do ensino médio que permite transparecer uma antítese oculta entre preocupações com a distribuição das riquezas e a desigualdade social versus o desinteresse pelas causas da produção econômica e do desenvolvimento. Sugerindo atenção a estes fatores, advogamos pela reinserção da Sociologia do desenvolvimento, passando por temas correspondentes, como o evolucionismo, o capital social, a economia e o método interdisciplinar como facilitador. Nessa perspectiva de justificação da renovação sociológica, correlacionamos tais preocupações com os pressupostos da Base Nacional Comum Curricular – BNCC, que é o documento norteador da Educação brasileira a partir de 2018.
INFÂNCIA BRASILEIRA: OLHARES PARA A VIOLÊNCIA DURANTE A PANDEMIA
Authors: Batomarco Nobre Lara , Voltarelli Monique Aparecida
Published: June 2023

O presente trabalho desenvolve-se a partir de uma pesquisa guarda-chuva, sobre infância e pandemia, realizada a partir do Programa Institucional de Bolsas de Iniciação Científica (PIBIC) da Universidade de Brasília no período de 2022 a 2023. Como recorte de um estudo mais amplo, esta pesquisa visa, a partir das produções científicas, a exploração dos aspectos relacionados à infância vivenciada durante a pandemia da Covid-19, com efeito   nas circunstâncias que corroboraram para a intensificação da violência infantil no território brasileiro durante o período de isolamento social, tendo em vista que a quarentena fortaleceu os fenômenos propulsores de diversos tipos de violência, que compõem uma temática de extrema urgência. Desta forma, investiga-se neste artigo as variadas características das violências praticadas contra as crianças, bem como as consequências e efeitos resultantes de agressões psicológicas, físicas, sexuais, de maus tratos, do rompimento dos direitos infantis e até da violência mediada pelas tecnologias digitais a partir das publicações acadêmicas deste período.
LA ENSEÑANZA MUSICAL EN LA FORMACIÓN DE DOCENTES PARA LAS PRIMERAS INFANCIAS
Authors: Zilli Lía Rosa
Published: June 2023

El presente trabajo expone y socializa algunas dimensiones posibles de abordarse desde la Educación Musical en la formación de docentes de Educación Inicial.

La discusión y la reflexión sobre diversas instancias vivenciales en la formación superior se estructuran en torno al desarrollo de juegos musicales y de ficción, de estímulos concordantes, de enfoque multimodal de obras musicales y de algunos aportes desde la pedagogía que discute la noción de destino -que refiere a una pérdida de singularidad que se posa sobre las infancias- cuando se trata de pensar políticas educativas y formación de las mismas. A partir de allí, este trabajo instaura un plural de posibilidades que situadas desde la enseñanza musical se pueden ofrecer a quienes trabajan junto a ellas.

Se proponen algunas dimensiones de análisis que a partir de la musicalidad comunicativa, del enfoque de la cognición musical temprana y la teoría de la cognición corporeizada posibilitan en las prácticas musicales junto a las infancias: la escucha, el disfrute, la experimentación y la producción-contextualización de diferentes manifestaciones artísticas en la Educación Inicial.
ENSEÑANZA DE LA LITERATURA EN EL PRIMER CICLO DEL NIVEL INICIAL, TRADICIONES, SABERES Y PRÁCTICAS DOCENTES EN JARDINES DE LA CIUDAD DE SANTA FE (ARGENTINA)
Authors: Paniccia Adriana
Published: June 2023

Este trabajo de investigación constituye una invitación a conocer cómo se configuran las propuestas de enseñanza de la literatura de los docentes en el primer ciclo del nivel inicial, cuáles son las tradiciones que las sustentan y los saberes que se ponen en juego durante el diseño y puesta en práctica de las mismas.

Dicha investigación se llevó a cabo durante el período 2020 se tomó como muestra un total de veinte instituciones del Nivel Inicial de la Ciudad de Santa Fe, que cuentan con un mínimo de dos secciones Primer Ciclo.

El diseño metodológico de estudio de caso consideró las siguientes etapas de investigación cualitativa, elaboración de las encuestas y realización de entrevistas semiestructuradas a las docentes del nivel inicial.

Esto permitió un acercamiento a conocer las prácticas de literatura que realizan las docentes en las salas y a los obstáculos que se presentan en la concreción de las mismas requiriendo por parte del docente reflexionar acerca del sentido que sustentan sus decisiones cotidianas y tener en cuenta conocimientos que permitan abordar a la literatura como un discurso literario, para mejorar las prácticas educativas.

 

 

Palabras clave: enseñanza, literatura, nivel inicial, prácticas docentes
O GARIMPO ILEGAL E A SAÚDE DOS IANOMÂMIS
Authors: Teixeira Cunha Wéltima
Published: June 2023

O mercúrio é um metal mais estudado em razão da sua utilização e consequências danosas aos humanos e ao ecossistema.  Esse fato se deve aos efeitos tóxicos para a saúde humana e contaminação ambiental, descritos e comprovados na literatura. O território dos ianomâmis faz fronteira entre Brasil e Venezuela da seguinte forma, ao norte de Roraima, ao sul da Venezuela e ao nordeste da Amazônia do Brasil. A subsistência desses indígenas se dá por meio da riqueza da floresta amazônica aliada a respeitosa sabedoria praticada por eles repassadas de geração para geração e também do plantio de suas roças. Diante disso o objetivo é disseminar informações sobre a nocividade do mercúrio para a saúde dos ianomâmis nos últimos quatros anos, assim como, as causas que influenciam o estado de desnutrição, doenças e morte desses povos originários. A pesquisa bibliográfica foi realizada a partir de referencial teórico em livros e site confiáveis, como registros de uma realidade excludente e de possível extermínio. A pesquisa evidencia os malefícios causados na saúde dos ianomâmis e no ecossistema, pelos invasores garimpeiros nas terras indígenas
Exploring the working conditions and performance of healthcare providers: The emerging market study
Authors: Attah Frank Mbeh , Akintola Abayomi , Archibong Esther Patrick , Bassey Umo Antigha , Nwadike Ngozi Christina , Dan Felicia Agbor-Obun , Ofem Nnana Okoi , Okpa John Thompson , Abang Thelma Aya , Ajimase Angela Ahowbewon
Published: June 2023

The study examines the extent to which working conditions affect the performance of healthcare providers. The design was exploratory, using both quantitative and qualitative data. Data were obtained from 490 medical personnel at the University of Calabar Teaching Hospital (UCTH). The research used a multi-stage sampling technique. Data were analysed using descriptive statistics such as percentages and frequency tables, while the chi-square test was used to test the significance of the relationship between the two hypotheses stated. The findings of the study reveal that male respondents are less likely to perceive non-payment of hazard allowances as affecting their performance than female respondents. The study also reveals that younger healthcare providers perceive the work environment as affecting their performance more than their older colleagues (Aduo-Adjei et al., 2016). As a result, the study recommends specific interventions to address the unique working conditions and challenges that various groups of medical personnel face. This will ensure that each category of medical personnel is given favourable conditions to improve their performance, which, in the long run, will ensure effective healthcare delivery.
Editorial: Recent trends in governing businesses practices
Authors: El-Bannany Magdi
Published: June 2023

It is our pleasure to share some thoughts about how the papers published in the current issue of the Journal of Governance and Regulation contribute to the existing related literature with the hope to enable our readers to outline the new and most challenging issues of research in corporate governance and related topics. The papers published in this issue of the Journal of Governance and Regulation have contributed to the ongoing discussion of governance and regulation, and have provided valuable insight into current developments and future prospects in this area. There have been a number of remarkable developments in the field of governance, regulation, and related fields in recent years, which are reflected in the research topics covered in this issue.
DECODING COLONY SIZE OF AMAZONIAN STINGLESS BEES THROUGH INTRINSIC PARAMETERS
Authors: LEÃO Kamila Leão , Campbell Alistair , Veiga Jamille , Menezes Cristiano , CONTRERA Felipe Andrés León
Published: June 2023

1. Stingless bees live in populous colonies that vary in size from a few
hundred individuals to tens of thousands, although information on actual
colony size is limited. Determining colony sizes using easily measurable
biological parameters are important steps to understanding their life
histories and ease their utilization and keeping. The objectives of this
study were to determine the colony size of five Amazonian stingless bee
species (Melipona flavolineata, Melipona fasciculata,
Scaptotrigona aff. postica, Frieseomelitta longipes
and Plebeia minima), and to identify biological parameters that
covary with colony size. 2. The number of brood cells, adult bees, and
food stocks were counted under laboratory conditions, alongside field
assessments of egg-laying rate and external activity of adult workers.
To identify covariates of colony size, the number of adult bees was
regressed against the number of brood cells, egg-laying rate, external
activity of adult workers, and food stocks, and the best Candidate
models were ranked using the Akaike Information Criterion. 3. Mean (±
s.d.) adult population sizes were: 1,046 ± 185 in M.
flavolineata; 593 ± 300 in M. fasciculata; 7,404 ± 1,391 in
S. aff. postica; 2,425 ± 1,000 in F. longipes; and
405 ± 254 in P. minima. We showed that the external activity is
the biological parameter, after the number of brood cells, that presents
the best relationship with the number of adult bees, which can be easily
evaluated in the field.
Pre-existing allergic diseases as risk factors for long-term Long-COVID symptoms: a systematic review of prospective cohort studies
Authors: Wolff Doreen , Drewitz Karl Philipp , Ulrich Angela , Siegels Doreen , Deckert Stefanie , Sprenger Antonia Anabella , Kuper Paula Ricarda , Schmitt Jochen , Munblit Daniel , Apfelbacher Christian
Published: June 2023

Background: The role of allergy as risk factor for Long-COVID (LC) is
unclear. We aimed to systematically review and appraise the
epidemiological evidence on allergic diseases as risk factors for LC
(PROSPERO: CRD42023391245). Methods: We examined literature for
prospective cohort studies with a follow-up duration of 12 months for LC
symptoms, published within the timeframe from January 2020 and January
2023 that recruited individuals with confirmed SARS-CoV-2 infection and
information on pre-existing allergic diseases. Risk of bias and
certainty of evidence were assessed (GRADE). Random effects
meta-analyses were used to pool unadjusted ORs within homogeneous data
subsets. Results: We identified 13 studies (participants range = 39 -
1,950), all of which were associated with high risk of bias. Four of
these studies did not provide data to calculate ORs. Significant
associations were observed between increased LC incidences and
pre-existing asthma measured in hospital-based populations ( n =
6) and pre-existing rhinitis ( n = 3) ( OR = 1.94; 95% CI
[1.08, 3.50]; OR = 1.96; 95% CI [1.61, 2.39]),
respectively. However, the level of certainty regarding these exposure
outcome associations was very low. Conclusion: Findings show that
allergies may increase the risk of LC, although the reliability of this
evidence is tenuous.
A Neural Network Based Background Calibration for Pipelined-SAR ADCs at Low Hardware Cost
Authors: Xiang Yuguo , Chen Min , Zhai Danfeng , Zhao Yutong , Ren Junyan , Ye Fan
Published: June 2023

This paper proposes a background calibration scheme for the
pipelined-SAR ADC based on the neural network. Due to the nonlinear
function fitting capability of the neural network, the linearity of the
ADC is improved effectively. However, the hardware complexity of the
neural network limits its application and promotion in ADC calibration.
Hence, this paper also presents the optimization schemes, including the
neuron-based sharing neural network and the partially binarized with
fixed neural network, in terms of calibration architecture and
algorithm. A 60 MS/s 14-bit pipelined-SAR ADC prototyped in 28-nm
technology is utilized to verify the feasibility of the proposed
calibration method. The measurement results show that the proposed
calibration enhances the SFDR and SNDR from 68.3 dB and 44.6 dB to 95.4
dB and 65.4 dB at low frequency, and from 56.8 dB and 35.6 dB to 90.6 dB
and 63.6 dB at Nyquist frequency. Meanwhile, the original calibrator and
improved calibrator are synthesized in Synopsys Design Compiler to
compare their hardware complexity. Compared with the unoptimized
version, the optimized schemes can decrease the logic area and the
network weights up to 76% and 52%, with negligible loss in calibration
performance.
Serological methods for the detection of antibodies against Monkeypox virus applicable for laboratories with different biosafety levels
Authors: Grossegesse Marica , Stern Daniel , Hofmann Natalie , Kohl Claudia , Michel Janine , Nitsche Andreas
Published: June 2023

The monkeypox virus (MPXV) outbreak in 2022 has renewed interest in the
detection of antibodies against orthopox viruses (OPXV) and MPXV, as
serological methods can aid diagnostics and are key to epidemiological
studies. Here three complementary serological methods are described with
different strengths to aid the development and evaluation of in-house
assays: An immunofluorescence assay (IFA) for specific detection of IgG
and IgM, an enzyme-linked immunosorbent assay (ELISA) for higher sample
throughput to aid epidemiological studies and a neutralization test (NT)
to detect virus neutralising antibodies. As implementation of
MPXV-specific diagnostics is often hampered by the requirement for a
dedicated biosafety level 3 laboratory (BSL-3), the focus is on
biosafety aspects to facilitate safe testing also under BSL-2
conditions. To this aim, IFA and NT titres of sera are compared after
MPXV or cowpox virus infection or vaccinia virus immunization by using
both homologous and heterologous antigens. Because of a large degree of
cross-reactivity, vaccinia virus could be used as a less virulent
alternative to MPXV, as VACV can be handled under BSL-2 conditions.
Furthermore, an inactivation method to remove potentially infectious
virus particles from viraemic sera without compromising antibody
detection was developed. Although the existing immunological
cross-reactivity between OPXV prevents species differentiation by
general serological methods, it also provides an opportunity for the
interchangeable usage of different OPXV species in serological assays,
enabling MPXV serology outside of BSL-3 facilities.
Neutrophil Aggregates and Elastin Degradation Compromise Lung Architecture in Fatal COVID-19
Authors: Narasaraju Teluguakula , Neeli Indira , L Sheila Criswell , Krishnappa Amita , Meng Wenzhao , Silva Vasuki , Bila Galyna , Vovk Volodymyr , Serhiy Zolotukhin , L Gary Bowlin , Meyer Nuala , Prak Eline T. Luning , Radic Marko , Bilyy Rostyslav
Published: June 2023

Pulmonary fibrosis, profound alveolitis, and the failure to restore
alveolar epithelial architecture are major causes of respiratory failure
in fatal COVID-19. However, contributing factors to abnormal fibrosis in
critically ill COVID-19 patients are yet to be understood. This study
analyzed the histopathology of lung autopsy samples from eight COVID-19
and six non-COVID-19 post-mortems. The distribution and changes in
extracellular matrix (ECM) proteins, including elastin and collagen in
lung alveoli, were quantitatively assessed through morphometric
analyses. These studies reveal massive degradation of elastin fibers
along the thin-alveolar walls of the lung parenchyma that supersedes
interstitial collagenous fibrosis and intra-alveolar fibrotic
abnormalities. Injured lungs with collapsed alveoli and organized
fibrotic regions exhibited widespread elastolysis. Further,
immunoblotting of lung autopsy extracts validated extensive elastin
degradation. Importantly, loss of elastin was correlated with induction
of neutrophil elastase (NE), a potent protease that degrades ECM, and
increased staining of peptidylarginine deiminase, a marker for
neutrophil extracellular traps release, and extensive epithelial
necrosis. Further, elevated plasma levels of NE-alpha1-antitrypsin
complex in hospitalized COVID-19 patients indicate dysregulated
neutrophil activity. These findings place elastin degradation at the
center of alveolar structural disintegration and argue that elastolysis
and alveolitis lead to abnormal ECM repair and fibrosis in fatal
COVID-19.
Differentiating EDRs from the Background Magnetopause Current Sheet: A Statistical Study
Authors: Beedle Jason M H , Gershman Daniel J , Uritsky Vadim M , Phan Tai D , Giles Barbara L.
Published: June 2023

The solar wind is a continuous outflow of charged particles from the
Sun’s atmosphere into the solar system. At Earth, the solar wind’s
outward pressure is balanced by the Earth’s magnetic field in a boundary
layer known as the magnetopause. Plasma density and temperature
differences across the boundary layer generate the Chapman-Ferraro
current which supports the magnetopause. Along the dayside magnetopause,
magnetic reconnection can occur in electron diffusion regions (EDRs)
embedded into the larger ion diffusion regions (IDRs). These diffusion
regions form when opposing magnetic field lines in the solar wind and
Earth’s magnetic field merge, releasing magnetic energy into the
surrounding plasma. While previous studies have given us a general
understanding of the structure of these diffusion regions, we still do
not have a good grasp of how they are statistically differentiated from
the non-diffusion region magnetopause. By investigating 251 magnetopause
crossings from NASA’s Magnetospheric Multiscale (MMS) Mission, we
demonstrate that EDR magnetopause crossings show current densities an
order of magnitude higher than non-EDR magnetopause crossings -
crossings that either passed through the reconnection exhausts or
through the non-reconnecting magnetopause. Significant current
signatures parallel to the local magnetic field in EDR crossings are
also identified, which is in contrast to the dominantly perpendicular
current found in the non-EDR magnetopause. Additionally, we show that
the ion velocity along the magnetopause is highly correlated with a
crossing’s location, indicating the presence of magnetosheath flows
inside the magnetopause current sheet.
Using Tidally-Driven Elastic Strains to Infer Regional Variations in Crustal Thickness at Enceladus
Authors: Berne Alexander , Simons Mark , Keane James T. , Park Ryan S.
Published: June 2023

Constraining the spatial variability of the thickness of the ice shell
of Enceladus (i.e., the crust) is central to our understanding of its
thermodynamics and habitability. In this study, we develop a new
methodology to infer regional variations in crustal thickness using
measurements of tidally-driven elastic strain. As proof of concept, we
recover thickness variations from synthetic finite-element models of the
crust subjected to diurnal eccentricity tides. We demonstrate recovery
of crustal thickness to within ~2 km of true values with
< 0.2 km error over spherical harmonic degrees l ≤ 12
(corresponding to half-wavelengths ≥ 60 km). Our computed uncertainty is
significantly smaller than the inherent ~10 km ambiguity
associated with inferring variations in crustal thickness solely from
gravity and topography measurements. We therefore conclude that
measuring elastic strain provides a relatively robust approach for
probing crustal structure at Enceladus.
Breast Cancer Management Research Trends: A Bibliometric Analysis
Authors: Abdul Aziz Nor Intan Shamimi , Ali Mass Hareeza , Jamil Ahmad Taufik , Ab Aziz Yuhanis
Published: June 2023

Breast cancer is the most prevalent type of cancer in women and has a significant economic impact worldwide. Consequently, there is a need to analyze the disease's research trend academically to determine the breast cancer publishing trend based on a certain period of its collection properties. Bibliometric analysis is used to examine the research trend in breast cancer care through time using various data. Several tools, including the PRISMA flow diagram, Microsoft Excel for frequency analysis, Harzing's Publish or Perish for citation metrics and other pertinent analyses, and VOSviewer for image visualization and bibliometric networks, were used to study this article. Using the TITLE search strategy and the Scopus database, 3,532 articles were located. It was discovered that the trends in research publications rose steadily from one year to the next. Between 1932 and 2021, 3,532 publications will be produced with a total of 61,274 citations, which breaks down to 688.47 citations per year, 17.35 citations per cited paper, and 4.02 citations per author. The United States, Italy, and the United Kingdom have produced the most co-authored works in this discipline. Even though the annual incidence rate of breast cancer remains high, these findings appear promising for determining the most effective treatments, procedures, and management strategies. The guideline standard requires further attention at a higher level.
The Work from Home Revolution: WFH Starter Kit
Authors: Mohd Sharip Sharfizie , Mohd Rashid Nur Rasyida , Abdul Hamid Syahrul Bariah , Abdullah Asiah , Pungot Noor Hidayah
Published: June 2023

The implications of the COVID-19 pandemic have greatly changed the norm in the employment system. Workers in both the public and private sectors are now adapted to the term "Work from Home" (WFH). Also, despite the little information on reliable practices for working from home, employees are nevertheless expected to perform at their highest level in accordance with the organizational goals.  Therefore, this study is aimed to evaluate the need of establishing a guideline for WFH. A total of 178 employees from both private and government sectors were recruited in this survey. Findings showed that 69.1% of staff agreed their organization should provide them with proper guidelines in the implementation of WFH. It means that when they have specific guidelines it enables them to work more independently which also exhibits flexibility and creativity. As a conclusion, the developed and validated WFH manual handbook is able to become the main reference for employees for them to prepare physically and mentally while working efficiently from home.
The Effect of Social Media Influencers on Fashion Counterfeit Purchase Intention among Young Generation
Authors: Renganathan Tamil Selvi , Teh Goi Mei
Published: June 2023

This study aims to examine the effect of social media influencers on fashion counterfeit purchase intention among the young generation. Social Media Influencer (SMI) has been a dominant marketing trend and businesses heavily invest in SMIs to carry out promotional activities. However, the dimensions of SMI have not been examined widely on fashion counterfeit purchase intention among the young generation. A total of six dimensions of SMI namely, inspiring, technical skills, enjoyability, similarity, informativeness and credibility were used for this study. Data was collected from 389 young generations via online techniques. The findings show that technical skills and informativeness significantly influence counterfeit purchase intention among the young generation. The findings of the study are useful for policymakers to control social media influencers.
An Application of Lean Principle in a Call Center at Sarawak
Authors: Abdul Wahed Zalina Salmah , Anis Azilah , Daud Azimah
Published: June 2023

Customer follow-ups or repeat calls are common in a call center primarily due to unresolved cases that turn into aging cases. Different case category presents different complexity with different outcome which this case study demonstrates. The present study thus proposes the Lean principle to be applied in the workflow to analyze each process activity in an attempt to find the root cause of the aging cases that do not conform to the established time function mapping. Five respondents were chosen amongst the call center personnel for a semi-structured interview enabling them to express themselves freely within the context of the dilemma they are facing. The respondents share the same desire to receive timely answers or information to maintain customer satisfaction levels. The Lean principle enables this case study to formulate a recommendation that ties in with Lean true nature for continuous improvement.
Body thermoregulation and serum metabolic profile of Kano Brown bucks fed Pluerotus ostreatus biodegraded sugarcane scrapings
Authors: Olafadehan Olurotimi , Anaso Emmanuel , Shoyombo Ayoola , Okunade Sunday
Published: June 2023

The study assessed if feeding of Pleurotus ostreatus biodegraded sugarcane
scrapings (BSS) would have detrimental effects on body thermoregulation and
serum metabolic profile of goats. Twenty-one healthy male Kano Brown bucks
(6 - 7 months of age; 9.44 ? 0.39 kg mean body weight) were stratified based
on their BW into three treatment groups containing 0 (T1), 15 (T2) and 30%
(T3) of BSS in a completely randomised design. Serum total protein, albumin,
globulin and albumin:globulin ratio were greater (P<0.05) in T2 than in T1
and T3. Serum urea was higher (P<0.05) in T3 relative to T1 and T2. While
serum glucose was greater in BSS diets, cholesterol and alanine transaminase
were higher in the T1 than in BSS diets (P<0.05). Alanine phosphatase
decreased in the order: T1 > T2 > T3 (P<0.05). Serum creatinine, aspartate
transaminase, total bilirubin, sodium, potassium, calcium and bicarbonate,
rectal temperature, earlobe temperature, heart rate and respiratory rate
were not influenced (P>0.05) by dietary treatments. Values of all serum
metabolic indices and body vital signs were within normal ranges for goats.
Results show that Pleurotus ostreatus biodegraded sugarcane scrapings can be
used up to 30% in the diets of goats without negatively impacting their body
thermoregulation, metabolic welfare and health.
155-OR: Remnant Cholesterol Predicts Major Cardiovascular Events in Cardiovascular Disease Patients with NAFLD
Authors: LARCHER BARBARA , MADER ARTHUR , SPRENGER LUKAS , VONBANK ALEXANDER , MAECHLER MAXIMILIAN , PLATTNER THOMAS , LEIHERER ANDREAS , MUENDLEIN AXEL , DREXEL HEINZ , SAELY CHRISTOPH H.
Published: June 2023

Remnant cholesterol has attracted interest as a marker of cardiovascular event risk. The power of remnant cholesterol to predict major cardiovascular events (MACE) in patients with nonalcoholic fatty liver disease (NAFLD) is unclear and is addressed in the present study. We enrolled a high-risk cohort of 1420 consecutive patients with established cardiovascular disease (1183 patients with stable coronary artery disease and 237 patients with peripheral artery disease). NAFLD was diagnosed using the validated fatty liver index (FLI). Prospectively, MACE including cardiovascular death, non-fatal myocardial infarction and non-fatal stroke were recorded over a mean follow-up period of 9.6±5.0 years. At baseline, remnant cholesterol was significantly higher in patients with NAFLD (n=683) than in patients who did not have NAFLD (29 ±.26 mg/dl vs. 19 ±16 mg/dl; p<0.001). During follow-up, 570 of our patients suffered MACE. Remnant cholesterol in Cox regression models adjusting for age, sex, hypertension, smoking, diabetes mellitus, body mass index and LDL cholesterol independently predicted MACE in the total study population (standardized adjusted HR 1.15 [1.06-1.24], p<0.001), and both in patients with NAFLD as well as in those who did not have NAFLD (standardized adjusted HRs 1.16 [1.03-1.30], p=0.012 and 1.14 [1.02-1.27], p=0.028, respectively). From our data we conclude that remnant cholesterol is a predictor of MACE in cardiovascular disease patients with NAFLD.

Disclosure

B. Larcher: None. A. Mader: None. L. Sprenger: None. A. Vonbank: None. M. Maechler: None. T. Plattner: None. A. Leiherer: None. A. Muendlein: None. H. Drexel: None. C.H. Saely: None.
1599-P: Regulation of Mitochondrial Dynamics Ameliorates Hepatic Steatosis through TFEB Activation
Authors: YOO JIN , CHEOL HWANG YOU
Published: June 2023

Nonalcoholic fatty liver disease (NAFLD) is a common cause of liver disease that is closely related to metabolic syndromes, obesity, and type 2diabetes. There is strong evidence that mitochondrial dysfunction plays a significant role in the development and progression of NAFLD. Recently, growing evidence suggests that the TFEB plays a pivotal role in mitochondrial dynamics. In this study, we investigated that mitochondrial dynamics play the potential role and mechanisms of TFEB in the amelioration of NAFLD. FFA increased expression of mitochondrial fission proteins p-Drp1, Fis1 and decreased expression of fusion proteins OPA1, Mfn2 and inhibition of TFEB activation. Mitotracker stain significantly increased in the proportion of cells with fragmented mitochondria in FFA-treated cells. HFD-fed mice displayed histology consistent with pathological hepatic steatosis. EM analysis indicated that HFD-fed mitochondria tended to be shorter and more round than ND-fed mitochondria. Western blot analyses reveal increased expression of the fission proteins, p-Drp1, Fis1, and significantly decreased in the fusion protein, Mfn2 and OPA1 in HFD-fed group. In vivo Tfeb knockout dramatically increased hepatic fat accumulation, liver ballooning in HFD-fed mice. EM analysis showed that HFD-fed Tfeb knockout mice had more rounded and swollen mitochondria, indicating that TFEB was dependent on the regulation of mitochondrial fragmentation. In vivo Tfeb knockout reveal significantly increased expression of the fission proteins in HFD-fed group. To demonstrated the direct regulatory mechanism of mitochondrial dynamics and TFEB activation, we used siRNA DRP1 and Mdivi-1. Inhibition of Drp1 promotes mitochondrial fusion, increased expression of fusion protein and reduced fat accumulation and activated TFEB. These results suggest a role in improving hepatic steatosis through regulation of TFEB-mediated mitochondrial dynamics in NAFLD.

Disclosure

J.Yoo: Other Relationship; American Diabetes Association. Y.Hwang: None.

Funding

National Research Foundation of Korea (2022R1I1A1A01069899)
1765-P: Direct ß-Cell Effects of miR-6727-3p, an miRNA Related to Improved ß-Cell Function in Humans
Authors: ZRAIKA SAKENEH , BARROW BREANNE , ENQUOBAHRIE DANIEL , BAMMLER THEO K. , MACDONALD JAMES , SRINOUANPRACHANH SENGKEO , CHUEN GARY CHAN KWUN , BOYKO EDWARD J. , KAHN STEVEN E. , WANDER PANDORA
Published: June 2023

Most people with type 2 diabetes (T2D) have limited improvement in β-cell function with glucose-lowering treatment; but we know little about contributing factors. Plasma miRNAs may reflect or predict treatment response at the level of the β cell. In youth treated with insulin glargine followed by metformin in the Restoring Insulin Secretion Study, we found that miR-6727-3p was positively associated with treatment response. Thus, we sought to determine whether miR-6727-3p has a direct effect on islets to improve insulin secretion and decrease cell death under T2D conditions. C57BL/6 mouse islets were treated for 48 h with 11.1 mM glucose (considered “normal” for mouse islets) or 25 mM glucose + 0.5 mM palmitate (“T2D”) in the presence of 5 nM miR-6727-3p mimic or miR-scramble. Thereafter, we assessed glucose-stimulated insulin secretion (GSIS) and islet cell death. T2D conditions resulted in elevated basal and reduced GSIS (Table). Regardless of condition, miR-6727-3p had no effect to change basal or GSIS. As expected, cell death increased in islets cultured in T2D vs normal conditions, but surprisingly, miR-6727-3p further exacerbated cell death under both conditions. Together, these data suggest miR-6727-3p may not alter β-cell function but that it may be deleterious to β-cell survival. Moreover, higher levels of plasma miR-6727-3p in responders are likely unrelated to treatment response.

Disclosure

S.Zraika: None. P.Wander: None. B.Barrow: None. D.Enquobahrie: None. T.K.Bammler: None. J.Macdonald: None. S.Srinouanprachanh: None. K.Chan: None. E.J.Boyko: None. S.E.Kahn: Advisory Panel; Anji Pharmaceuticals, Bayer Inc., Boehringer Ingelheim Inc., Eli Lilly and Company, Merck & Co., Inc., Other Relationship; Novo Nordisk.

Funding

National Institutes of Health (R01DK132355)
229-OR: A Calibration Protocol for Continuous Glucose Monitor Accuracy in the ICU
Authors: BANN SEWON , HERCUS JESS C. , ATKINS PAUL , ALKHAIRY AREEJ , THOMPSON DAVID M.
Published: June 2023

Guidelines now recommend inpatient continuous glucose monitor (CGM) use, assuming that it is sufficiently accurate due to its apparent safety. The FDA issued a non-objection letter for inpatient CGM use, but it is not yet officially approved for hospitals, including in the ICU. To further study CGM in the ICU, we tested the accuracy of the Dexcom G6 (G6) in 32 adults in a medical-surgical ICU in Vancouver, BC using a calibration protocol in 1035 matched CGM and arterial point-of-care (POC) pairs. Our first uncalibrated study had a mean absolute relative differential (MARD) of 13.24%, which barely meets the critical care expert recommendation of MARD <14%. This study aims to show a higher accuracy can be achieved with a simple calibration protocol on Day 1, then none thereafter. The MARD for calibrated patients was 9.27%, significantly lower than 13.19% for uncalibrated patients (p<0.001). Calibration also had excellent safety with 100% of values within Clarke Error Grid Zones A and B compared to 99.07% without calibration. Our protocol achieved the lowest MARD and safest Clarke Error Grid profile of any ICU study comparing CGM to standard of care arterial POC and well exceeds the critical care expert recommendations. Our large sample of heterogenous critically ill patients also reached comparable accuracy to the MARD of 9% for G6 in outpatients. We believe our calibration protocol will allow CGM to be used with sufficient accuracy in the ICU.

Disclosure

S.Bann: None. J.C.Hercus: None. P.Atkins: None. A.Alkhairy: None. D.M.Thompson: None.
249-OR: Predictors of Impaired Awareness of Hypoglycemia in Adults with Type 1 Diabetes
Authors: GIBB FRASER W. , STIMSON ROLAND H. , FORBES SHAREEN , DOVER ANNA R.
Published: June 2023

Background: Impaired awareness of hypoglycemia (IAH) is associated with a substantially increased risk of severe hypoglycemia (SH) in type 1 diabetes. Risk factors for IAH are not well characterized in the modern context. We assessed associations with IAH in adults with type 1 diabetes.

Methods: Cross-sectional observational study. 782/2210 (35.4%) of people with type 1 diabetes attending a UK diabetes center completed a questionnaire with questions on hypoglycemia awareness and mental health. Data were also extracted for CGM metrics and additional clinical and demographic information.

Results: 54.1% of participants were men. Median age was 51 years and diabetes duration was 24 years. 27.0% were on CSII. 88.6% were using CGM. IAH (Gold score ≥ 4) was present in 21.3%. 10.0% had a hypoglycemia awareness threshold less than 3.0 mM (54mg/dl). 5.1% gave a recent history of severe hypoglycemia. IAH associations are presented in the table. PHQ-2 depression screen positive (HR 2.1, p = 0.009), socioeconomic deprivation (HR 1.8, p = 0.006) and female sex (HR 1.8, p = 0.002) were independently associated with IAH.

Discussion: IAH, as defined by elevated Gold Score, was associated with a near four-fold increased risk of SH. Psychological approaches to IAH have shown promise and these data highlight the importance of adequate mental health screening, especially in IAH.

Disclosure

F.W.Gibb: Advisory Panel; Abbott. R.H.Stimson: None. S.Forbes: None. A.R.Dover: Other Relationship; Abbott Diabetes.
528-P: Different Glycemic Responses in People with T1 or T2DM after Use of an Insulin Injection Supporting App
Authors: SIEBER JOCHEN , WIENBARG INKA , MAHONEY ED , HAAK THOMAS
Published: June 2023

Lipohypertrophy, poor insulin injection technique and missed boluses are well-known issues in the management of diabetes but are sometimes overlooked. This study evaluated whether use of an app with digital training on correct injection routines, site rotation and injection related behaviors will improve glycemic control. Here, we present results of a post hoc analysis on CGM parameters. This was a prospective, open label study with patients on MDI (at least one basal and one bolus insulin injection), HbA1c ≥7% using an intermittent CGM device. A 4-week period without app use was followed by a 4-week period with the use of the app. Time below (<70mg/dl), in (70-180mg/dl), above (>180mg/dl) glycemic ranges, mean glucose, SD & CV were analyzed. 58 patients (37 male, 21 female) completed the study (mean age 52.0 ± 14.6y, diabetes duration 19.2 ± 12.5y, HbA1c 8.0 ± 0.8%, 35 T1DM, 23 T2DM). Overall (N=58), there were significant differences (p<0.001) between baseline and intervention for mean glucose (190.2 (39.2) vs 186.0 (42.0)), time in range (49.9 (17.1) vs 52.6 (18.3)) and time >180 mg/dl (48.2 (17.3) vs 45.4 (18.8)). No significant differences in % of values in hypoglycemia were observed. Table shows mean point estimates for differences from baseline for diabetes subgroups. The use of an insulin injection supporting app leads to improvements in glycemic measures with differences between people with T1DM & T2DM..

Disclosure

J.Sieber: Employee; Becton, Dickinson and Company, embecta, Stock/Shareholder; Becton, Dickinson and Company, embecta. I.Wienbarg: None. E.Mahoney: None. T.Haak: None.