bluuebunny/crossref_metadata_2025 huggingface dataset:
Congenital heart diseases pattern among children presenting to tertiary care hospital
Authors: Pasha Waseem , Ramchand Ramchand , Khokhar Rajab Ali , Sathio Shah Nawaz , Kanwal Mehwish , Aurangzeb Aurangzeb
Published: August 2023

Aim: To determine the pattern of congenital heart diseases among children presenting to tertiary care hospital. Material and Methods: A cross sectional study was carried out at Department of Paediatrics Cardiology, National institute of Cardiovascular Disease Karachi in the duration from November, 2022 to April, 2023. Total 171 patients were presented with CHD. Patients aged between 1 to 12 months of both genders. Pattern of CHD among the patients was determined. Results: Acyanotic CHD was seen in 74.26% patients. Cyanotic CHD was seen in 25.73% patients. Atrial Septal Defect (48.8%) was the most common presentation in acyanotic CHD patients while Tetralogy of Fallot was common presentation (40.9%) in cyanotic CHD patients. Conclusion: From our study we conclude that majority of the patients had acyanotic CHD as compared to cyanotic CHD, Ventricular Septal Defect and Atrial Septal Defect were more prevalent in cyanotic CHD while Tetralogy of Fallot was more common in cyanotic CHD.
A Review Paper on Identification of Ayurvedic Prakriti Types
Authors: Dhole Swati , S.E. Yedey
Published: August 2023

Human prakriti and tridosha are important for human health and fitness according to Ayurveda. A person's prakriti can be identified in Ayurveda in several ways. According to Ayurveda, every person born has five elements: earth, air, water, fire and space.We own distinctive balance of these five elements in assorted degrees. The balance of these elements is known as Tridosha. There are three basic doshas: Vata, Pitta and Kapha, and good health is considered a balance of these three doshas. Doctors evaluate these characteristics through examination and palpation to determine Prakriti in patients.The physician decides on diagnosis, primary prevention, and therapy based on the Prakriti of each individual. Prakriti assessment involves clinical examination including questions about physiological and behavioural traits. There is requirement to develop models correctly for predicting prakriti classes that have been used for foretell various diseases. Ayurvedic doctors examine the prakriti of a person either by accessing the physical features and or by inspecting the nature of their pulsation. Based on this investigation, they identify, prevent and cure disease in patients by prescribing medicine.
АНТИМОНОАМИНОКСИДАЗНЫE СВОЙСТВА НОВЫХ ПРОИЗВОДНЫХ ПИРИМИДИНОВ // ANTIMONOAMINOXIDASE PROPERTIES OF NEW PYRIMIDINE DERIVATIVES
Authors: Grigoryan Anahit , Harutyunyan Artur , Matsakyan Gyulnara , Paronikyan Ruzanna
Published: August 2023

В настоящей работе изучены антимоноаминоксидазные свойства новых синтезированных производных 6-метилпиримидинов. Исследования проводились на тканях бычьего мозга в условиях in vitro. Исследования показали, что эти соединения в концентрации 1,0 и 5,0 мкмоль/мл проявляют антимоноаминоксидазную активность, ингибируя дезаминирование серотонина. Исследуемые производные пиримидинов по эффективности дезаминирования серотонина условно разделены на три группы (сильные, умеренные, слабые). Полученные данные позволяют сделать заключение о возможности создания новых препаратов – антидепрессантов на основе ингибиторов моноаминооксидазы в ряду пиримидинов (МАО, ЕС-1.4.3.4.). // In the present work, we studied the antimonoamine oxidase properties of the newly synthesized 6-methylpyrimidine derivatives. The studies were carried out on bovine brain tissues under in vitro conditions. The study showed that these compounds at a concentration of 1.0 and 5.0 µmol/ml exhibit antimonoamine oxidase activity, inhibiting the deamination of serotonin. The studied pyrimidine derivatives are conditionally divided into three groups according to the efficiency of svrotonin deamination (strong, moderate, weak). The data obtained allow us to conclude that it is possible to create new antidepressants based on monoamine oxidase (MAO) inhibitors in the series of pyrimidines (EC-1.4.3.4.).
РОЛЬ УСЛУГ МАРКЕТИНГА В МЕНЕДЖМЕНТЕ АПТЕК // ROLE OF MARKETING SERVICES IN COMMUNITY PHARMACY MANAGEMENT
Authors: Beglaryan Margarita , Sulashvili Nodar
Published: August 2023

Согласно литературным данным, почти во всех странах розничная торговля лекарственных средствами – одна из движущих сил экономики. На современном этапе развития удовлетворение требований покупателей занимает особое место в стратегии, избираемой аптеками. Так как в этой сфере возникло много проблем, предметом нашего исследования стало качество услуг, предоставляемых в аптеках РА, и поведение потребителей. На основе анализа данных исследования мы выдвигаем ряд положений, применение которых коренным образом изменит качество услуг работников фармацевтической отрасли Армении, сделает поведение покупателей лекарственных средств управляемым. Это современное направление имеет практическое применение и в менеджменте аптеки, и в управлении потребительским поведением. Решение этой задачи будет способствовать повышению качества услуг провизоров/фармацевтов, что повлечет за собой увеличение товарооборота аптек. // Review of literature reveals that drug sale from local drugstores has become one of the forces influencing the growth of the economy. At present stage of the development one of the most important strategic factors for drugstores has become customer satisfaction. Since various problems have emerged in this area, current study has focused on the quality of services delivered by drugstores in the Republic of Armenia, and on customer behavior. The issue in question is highly relevant to the managerial staff of drugstores, to customers of drugstores and, of course, to the society in general. Having a solution to this problem, pharmacists will be able to deliver services of higher quality, thus ensuring pharmacies financial-economic enhancement.
СЕНСОМОТОРНАЯ ДЕЯТЕЛЬНОСТЬ ЧЕЛОВЕКА И ФОРМИРОВАНИЕ СОЦИУМА // SENSOMOTOR ACTIVITY OF HUMANS AND THE FORMATION OF SOCIETY
Authors: Sargsyan Vahram , Harutunyan Anahit , Kostanyan Hasmik , Misakyan Levon
Published: August 2023

Предлагается новый междисциплинарный подход для понимания механизмов формирования человеческого общества и маленьких копий социума – «внутреннего мира» человека. Научной базой для этого стали достижения современной нейрогенетики и физиологии. Представлены механизмы сенсомоторной деятельности для формирования психики человека и как следствие – формирование социума. Ценность исследования в его междисциплинарном подходе при решении и правильном понимании вопроса. В перспективе есть большое практическое применение в области контролируемого формирования социума. // A new interdisciplinary approach is proposed for understanding the mechanisms of formation of human society and small copies of society – the «inner world» of a person. The scientific basis for this was the achievements of modern neurogenetics and physiology. The mechanisms of sensorimotor activity for the formation of the human psyche and, as a result, the formation of society is presented. The value of research is in its interdisciplinary approach in solving and correctly understanding the issue. In the future, there is a great practical application in the field of controlled formation of society.
«ИНТЕРНАЦИОНАЛИЗАЦИЯ НА РОДИНЕ» КАК ФАКТОР КАЧЕСТВА ОБУЧЕНИЯ В ГОСУДАРСТВЕННЫХ ВЫСШИХ УЧЕБНЫХ ЗАВЕДЕНИЯХ ЛИТОВСКОЙ РЕСПУБЛИКИ / «INTERNATIONALISATION AT HOME» AS A FACTOR IN THE QUALITY OF STUDIES IN THE PUBLIC HIGHER COLLEGE EDUCATION IN THE REPUBLIC OF LITHUANIA
Authors: Jurgelionienė Rūta
Published: August 2023

Интернационализация является не только глобальным явлением, но и одной из основных движущих сил, влияющих на вузы, чтобы ответить на вызовы 21 века. Вузы находятся под давлением необходимости быть международными, растет потребность университетов позиционировать себя на глобальном рынке высшего образования, необходимость выяснить, какие навыки необходимы выпускникам для эффективного участия в жизни общества и экономики, а также растущее понимание того, что социальные компетенции университетов становятся более широкими и глобальными [26]. Политика Европейского союза, Болонский процесс и международные организации, которые повысили важность интернационализации в процессе реформ, способствовали усилению давления на вузы с целью развития интернационализации. Глобальная трансформация экономических, торговых, исследовательских и коммуникационных систем и влияние глобальных сил на местную жизнь значительно расширяют потребность во всесторонней интернационализации, а также мотивы и цели, которые ею движут. По мнению Knight, интернационализация высшего образования – это процесс, который развивается и как субъект, и как реакция на новые реалии и довольно неспокойные времена, с которыми сталкивается высшее образование. Интернационализация высшего образования является неотъемлемой частью высшего образования, которая связывает международные, межкультурные аспекты высшего образования со всеми членами сообщества. // Internationalisation is not only a global phenomenon, but also one of the main driving forces influencing HEIs to meet the challenges of the 21st century. HEIs are under pressure to be international, there is a growing need for universities to position themselves in the global higher education market, a need to find out what skills graduates need to be able to engage effectively in society and the economy, and a growing awareness that universities' social competences are becoming broader and more global [26]. European Union policies, the Bologna Process, and international organisations that have raised the importance of internationalisation in reform efforts have contributed to the increasing pressure on HEIs to develop internationalisation. The global transformation of economic, trade, research and communication systems and the impact of global forces on local life are greatly expanding the need for comprehensive internationalisation and the motives and objectives that drive it. According to Knight, higher education internationalisation is a process that is evolving both as an actor and as a reaction to the new realities and rather turbulent times facing higher education. The internationalization of higher education is an integral part of higher education, which connects the international, intercultural aspects of higher education with all members of the community.
КЛИНИЧЕСКИЙ СЛУЧАЙ ИМПЛАНТАЦИИ С ИСПОЛЬЗОВАНИЕМ СИСТЕМЫ ИМПЛАНТАТОВ С БИОАКТИВНЫМ ПОКРЫТИЕМ IMPLANT.UZ // THE CLINICAL CASE OF IMPLANTATION WITH THE USE OF THE IMPLANTS SYSTEM WITH BIOACTIVE COATING IMPLANT.UZ
Authors: Usmonov Farkhodzhon , Khabilov Nigman , Mun Tatyana , Kuvatova Umidakhon
Published: August 2023

Представленный клинический случай демонстрирует стандартный подход к лечению, адентии путем имплантации имплантатами с биоактивным покрытием системы «Implant.Uz». // The author of the article demonstrates a standard approach to the treatment of adentia by implantation with implants with a bioactive coating of the «Implant.uz» system in the presented clinical case.
ГЕРИАТРИЧЕСКИЕ ПРОБЛЕМЫ ЗАНЯТОСТИ В ЛАТВИИ ПОСЛЕ 65 ЛЕТ / GERIATRIC PROBLEMS OF EMPLOYMENT IN LATVIA AFTER 65+
Authors: Kudins Janis
Published: August 2023

Геронтология на сегодняшний день стала актуальной научной проблемой, так как она затрагивает вопросы продления жизни человека в пожилом возрасте. Известно, что к старению приводят генетические, биохимические и молекулярные процессы, протекающие в органах, клетках и тканях и приводящие к необратимым деструктивным изменениям. Занятость пожилых людей после 65 лет в различных сферах трудовой деятельности является одним из ключей к активному старению индивида. В данной статье рассматриваются проблемы стремительного роста занятости пожилых людей Латвии в возрасте старше 65 лет. // Gerontology has become an urgent scientific problem today, as it touches upon the issues of extending a person's life in old age. It is known that aging is caused by genetic, biochemical and molecular processes occurring in organs, cells and tissues and leading to irreversible destructive changes. Employment of older people 65+ in various areas of work is one of the keys to the active aging of the individual. This article discusses the problems of the rapid growth of employment of elderly people in Latvia over the age of 65.
ИГРОВЫЕ ТЕХНОЛОГИИ В ПОДГОТОВКЕ БУДУЩИХ ПСИХОЛОГОВ // GAME TECHNOLOGIES IN TRAINING FUTURE PSYCHOLOGISTS
Authors: Tleubekova Botakoz
Published: August 2023

В статье рассматриваются возможности игровых технологий в практике профессиональной подготовки будущих психологов. // The article discusses the possibilities of gaming technologies in the practice of professional training of future psychologists.
СРАВНИТЕЛЬНЫЙ АНАЛИЗ ПРОФЕССИОГРАММЫ БАКАЛАВРА СЕСТРИНСКОГО ДЕЛА // COMPARATIVE ANALYSIS OF PROFESSIOGRAMS OF NURSING BACHELOR
Authors: Lapik Svetlana
Published: August 2023

Нами проведен сравнительный анализ представлений о профессии академической медицинской сестры выпускников факультета высшего сестринского образования и преподавателей Тюменского медицинского университета. Их мнения похожи в оценке индивидуальных качеств и требований к профессиональной подготовке бакалавра, но совершенно различаются в представлениях о видах деятельности и о местах будущей работы, что может негативно повлиять на мотивацию к обучению. // We carried out a comparative analysis of the ideas about the profession of an academic nurse of graduates of the Faculty of Higher Nursing Education and teachers of the Tyumen Medical University. Their opinions are similar in assessing the individual qualities and requirements for the professional training of a bachelor, but they are completely different in their ideas about the types of activities and places of future work, which can negatively affect the motivation to study.
НАУЧНЫЙ РАЗГОВОР, ОСОБЕННОСТИ И ОБОСНОВАНИЕ ХАРАКТЕРИСТИК, ОБЪЕМОВ И ВОЗМОЖНОСТЕЙ РОЛИ ФАРМАЦЕВТА В АПТЕКЕ, В КЛИНИКЕ И В СФЕРЕ ЗДРАВООХРАНЕНИЯ И АДМИНИСТРАТИВНЫЕ ВОПРОСЫ ФАРМАЦЕВТИЧЕСКОГО ОБРАЗОВАНИЯ В ДВАДЦАТЬ ПЕРВОМ ВЕКЕ // THE SCIENTIFIC TALKS, REASONINGS, JUSTIFICATION AND CONTROVERSIES OF THE FEATURES, CHARACTERIZATIONS, SCOPE AND CAPACITIES FOR PHARMACIST ROLE IN PHARMACY, IN CLINIC AND IN HEALTH CARE SECTOR, AND ADMINISTRATIVE AND PHARMACEUTICAL EDUCATIONAL SUMMONS ISSUES IN THE TWENTY-FIRST CENTURY
Authors: Sulashvili Nodar , Beglaryan Margarita , Gorgaslidze Nana , Lobjanidze Tamar , Chichoyan Naira , Gerzmava Otar , Tsintsadze Tamar , Nikoleishvili Elza , Gabunia Luiza , Zarnadze Irine , Mchedluri Tea , Kvizhinadze Natia , Pkhakadze Irine , Gabunia Ketevani , Alavidze Nato , Abuladze Nino , Pkhakadze Giorgi , Giorgobiani Marina , Seniuk Igor , Zarnadze Shalva Davit
Published: August 2023

Основная цель исследования состояла в том, чтобы проанализировать особенности, характеристики, объем и возможности роли фармацевта в фармации, клинике и секторе здравоохранения, а также вопросы фармацевтического образования в двадцать первом веке. Исследование представляло собой количественное исследование и анализ особенностей, характеристик, масштабов и возможностей роли фармацевта в фармации, клинике и секторе здравоохранения, а также вопросы фармацевтического образования в двадцать первом веке с использованием анкет. Мы провели опросное исследование. В исследовании использовался метод глубинного интервью респондентов. Использовались 7 типов утвержденных анкет (респонденты отбирались случайным образом): Анкета для главных провизоров: в исследовании приняли участие 410 главных провизоров. Анкета для пациентов: в исследовании приняли участие 1506 пациентов. Анкета для работающего студента фармацевтического факультета: в исследовании приняли участие 222 работающих студента фармацевтического факультета. // The main goal of the study was to analyze the features, characterizations, scope and capacities for pharmacist role in pharmacy, in clinic and in health care sector and pharmaceutical educational summons issues in the twenty-first century. The study was a quantitative investigation and analysis of features, characterizations, scope and capacities for pharmacist role in pharmacy, in clinic and in health care sector and pharmaceutical educational summons issues in the twenty-first century by using questionnaires. Were conducted a survey study. The in-depth interview method of the respondents was used in the study. The 7 types of approved questionnaires were used (Respondents were randomly selected): Questionnaire for chief pharmacists: 410 chief pharmacists participated in the study. Questionnaire for patients: 1506 patients participated in the study. Questionnaire for the employed pharmacy faculty-student: 222 employed pharmacy faculty students participated in the study.
God at Work in the World: Theology and Mission in the Global Church
Authors: Peh Andrew
Published: August 2023

This is a book review of Lalsangkima Pachuau, God at Work in the World: Theology and Mission in the Global Church (Grand Rapids, MI: Baker Academic, 2022), xiv + 177 pp., ISBN: 9781540961365, $16.09, paperback.
Ontological (In-) Security and the Dark Night of the Soul
Authors: Kung Lap Yan
Published: August 2023

This study reflects on how Christian political prisoners in Hong Kong utilize their Christian resources to articulate and live with the ontological insecurity caused by incarceration. Hong Kongers consider political prisoners to be sufferers for Hong Kong rather than criminals, an interpretation that corresponds to the Christian notion of redemptive suffering. The Christian political prisoners interviewed in this study see their days in prison as the dark night of the soul in which a generative sense-making has emerged. The days in the dark night are painful, but ironically, their spirituality in the dark night exposes the injustice of rule by law, disempowers the threat of demoralization, changes the game theory from prisoner’s dilemma to warden’s dilemma, and illustrates that imprisonment can be turned to an unexpected platform for personal growth. This sense-breaking, despite as yet being weak, gives birth to a social narrative characterized by suffering in solidarity in contrast to the official narrative,“from chaos to order, from order to prosperity.”
Covenant, Constitutionalism, and Christian Liberty
Authors: Xiao Joyce
Published: August 2023

This article explores how Wang Yi lays the foundation for considering a political theology based on the ways in which covenant and related ideas were transformed into concrete social and political realities manifested in the American experiment. It further explores how the concept of covenant points Wang toward embracing the Reformed tradition and constructing his Reformed political theology to tackle problems he sees with current church-state relations in mainland China. This exploration shows that Wang’s construction of political theology is based on a misreading of the covenant concept and its relation to American constitutionalism. Wang also overlooks some biblical and theological meanings of covenant and draws on a particular reading of the Bible to justify his sociopolitical arguments. This misreading indicates that Wang’s approach to political theology is questionable because it is rooted in his misinterpretation of American constitutionalism and covenant.
Exploring the Old Testament in Asia: Evangelicals in Asian Christian Thought
Authors: Hauw Andreas
Published: August 2023

This is a book review of Exploring the Old Testament in Asia: Evangelicals in Asian Christian Thought, edited by Jerry Hwang and Angukali Rotokha (Carlisle: Langham, 2022), 276 pp., ISBN 978-1-83973-279-9, US$32.99, paperback.
Interpreting Scripture across Cultures: An Introduction to Cross-Cultural Hermeneutics
Authors: Leow Wen Pin
Published: August 2023

This is a book review of Will Brooks, Interpreting Scripture across Cultures: An Introduction to Cross-Cultural Hermeneutics (Eugene, OR: Wipf & Stock, 2022), x + 200 pp., ISBN: 978-1-6667-0748-9, $29.00, Paperback.
AN EXAMINATION OF THE COSTS AND OUTCOMES OF EDUCATION IN BOTH PRIVATE AND PUBLIC HIGH SCHOOLS, WITH EMPHASIS ON YARIPORA ZONE IN THE KULGAM DISTRICT
Authors: Salahuddin Rather  , Aejaz Ahmad Mir
Published: August 2023

ABASTRACTThe present study was intended to explore the analysis of the expenditures of educational institution in both government and private schools.Data on these components were compared between the public private schools in the zone. For each of these elements, indicators were discovered and attributes were created monthly and yearly fee spending, transportation costs, infra-structure and other study-related expenses were studied. The sample for the study was 50 students from different government and private schools of zone yaripora of kulgam district of union territory of Jammu and Kashmir, however, in order to minimise the extraneous effect the researcher has done multi stage random sampling. . A proportionate distribution of students was made, the researcher has used the cross tabulation and percentage methods .Results revealed the outcome from Private institutions is better than Government institutions. Besides the cost of education is very high.The students of Private institutions have better hold on holisticdevelopment. Publicschools having better infrastructure facilities, but public institutions are not providing suitable outcome
ANALYSIS OF PARTICIPATION OF MELABUN PERMAI GAPOKTAN MEMBERS TO FOLLOW THE PEOPLE'S OIL PALM REJUVENATION (PSR) PROGRAM IN BANGKA CENTRAL DISTRICT
Authors: Demsi Apriadi  , Eries Dyah Mustikarini  , Fournita Agustina  , Evahelda
Published: August 2023

The People's Oil Palm Rejuvenation Program (PSR) is a National Strategic Program as an effort by the Government to increase the productivity of oil palm plantations. One important factor that determines the success of replanting activities is the participation of farmers, where without the participation of farmers, rejuvenation activities will not be successful, due to the role of farmers as the main actors in agricultural development programs. The purpose of this study was to determine the level of farmer participation and the factors that are significantly related to the implementation of People's Oil Palm Rejuvenation (PSR) in Sungaiselan District, Central Bangka Regency. The study of Gapoktan Melabun Permai in Sungaiselan Subdistrict, Central Bangka Regency was carried out from May to June 2023. The sample in this study was Gapoktan Melabun Permai, Sungaiselan District in Central Bangka Regency, totaling 59, the sampling technique of this study was non-probability sampling using consecutive sampling method, data collection used a questionnaire that had been tested for validity and reliability. Methods of data analysis to determine the participation of Gapoktan Melabun Permai in PSR using multiple linear regression analysis. The results of the study found that the participation of Gapoktan Melabun Permai in the implementation of the People's Palm Oil Rejuvenation (PSR) program in Sungaiselan District, Central Bangka Regency, was in the very high category with a percentage of 91.58%. After conducting multiple linear regression analysis, there is a significant relationship between the factors of land area, motivation,
Achievement and Aspiration of Local Colleges and Universities on the Research Agenda of Funding Institutions: Basis for Research Capability Building
Authors: Mauricio Maricel F.
Published: August 2023

This study was conducted for a specific purpose: to assess the research culture in the local colleges and universities and to propose an enhanced research capacity-building program. There were sixteen informants of this study; four administrators and twelve faculty members in the local colleges and universities in the CAMANAVA area namely: The University of Caloocan City, City of Malabon University, Navotas Polytechnic College and Valenzuela City Polytechnic College. A Purposive sampling technique was used to identify the informants. The study made use of a qualitative research approach. The data were collected from individual interviews with the administrators and faculty members. Using open coding, six (6) themes were emerged from the interviews and analysis of the document: philosophical research perspective, impact on institution’s growth and development, motivational components in research engagement, promoting the research culture, managing challenges and impediments and enhancing research capability. The informants identified the challenges in the development of the intensified research culture in the local colleges and universities which includes the scarcity of funds, research skills and expertise, network resources, and time constraint. These can be resolved through the enhancement of research capabalities and development programs. Generally, the study concluded that the research is indeed a powerful tool in addressing institutional problems and the utmost contribution of faculty members of the local colleges and universities in the academic and curricular programs and institutional growth and development. The institutional support will address the compelling need of the local colleges and universities to improve their research capability and research output.
Therapeutic Efficacy of Shirodhara on Mental Health conditions and Sleep Disorders: A Review
Authors: Sonam Sonam , Kumar Mahapatra , S Rajagopala
Published: August 2023

Introduction: Data from National Mental Health Survey (NMHS) of India-2016 revealed that the prevalence of mental disorders in India is 13.7%. The prevalence of other mental disorders like anxiety, depression, substance use etc. was found 10% of the population, nearly twice more in urban metros and with significant gender differences. The available treatment options are based on symptoms severity. Thus, integrated care models are required to tackle the condition. Shirodhara, one of the classical treatments is being practiced since years to cure mental health conditions among individuals. This study was planned to review the effects of Shirodhara on mental health conditions.
Materials and Methods: A review was conducted using (Shirodhara) AND (Anxiety OR Depressive Disorder OR Depression OR Stress OR Mental Health OR Mental Disorders OR Sleep) as keywords. The articles with full paper, in English language and published during last 10 years were considered for the review.
Observations and Results: In the present review, total 5 Studies were found to be eligible and thus were included. The mental health condition of the patients was significantly improved in overall all the groups of the included trials. The effects are more prominent in comparative groups where Shirodhara has been used in combination or in addition with oral medications as compared to alone therapy. It is also observed that Cognitive functions, executive memory, sleep quality and quality of life were better improved with add on Shirodhara therapy.
Discussion: Mano-Vikara are mostly explained under Vata-Nanatmaja Vikara and of Vata and Pitta Dusthi Lakshan. Shirodhara is one of the best remedy of pacifying the abnormal Vata Doshas as per classics. No severe adverse events were reported in any of the five trials, but minor adverse events were reported by four participants in one trial.
Conclusion: Shirodhara is beneficial in improving mental health conditions. Hence, it can be used as one of the integrated treatment modality so as to encourage the multilevel approach with a solution of improving mental health conditions and quality of life of the people.
Rare presentation of Ulcerative Lichen Planus (Bars-e-Aswad Quroohi) – A Case Study
Authors: NAAZ IRAM , SHAHID MOHD , YOUSF NASIR
Published: August 2023

Introduction: Lichen planus is a T-cell-mediated autoimmune inflammatory disorder of the skin and mucous membranes. It appears as pruritic, violaceous papules and plaques most found on the wrists, lower back, and ankles. This paper presents the case of 32 years old married female patient, who came to the National Institute of Unani Medicine OPD Bengaluru. Clinical presentation: Her chief complaints were severe pain, itching, and ulcerated lesions on the dorsal and plantar aspects of feet with loss of all the toenails for eight years. The lesions appeared as erythematous papules on dorsal surface of both big toes of feet and spread to the plantar aspect. Initially, lesions were violaceous, scaly and dry. Later, painful fissures developed with oozing of blood. As disease progresses, nails of feet are involved leading to anonychia. Diagnosis: The patient was diagnosed clinically as ulcerative lichen planus resembled to Bars-e-Aswad Qroohi in the Unani system of medicine. Interventions: The patient was treated with Joshanda Munzij Sauda (decoction) and Majoon Ushba (compound formulation) orally and Marham Asfeedaj for local application after foot bath from Safoofe Zaj. Outcome: Assessment of efficacy was done by physician global assessment (PGA) scales in three parameters (pruritus, pain, and fissure) before and after treatment. Conclusion: This Unani formulation effectively improves pruritus, pain, scaling, and fissures in Ulcerative lichen planus and may be considered for complimentary management of ULP.
Standardization of Koshtha by Koshtha Deciding Scale (KDS): An Observational study
Authors: Chandaliya Sachin , Katole Harshaprabha , Girde Samir
Published: August 2023

Koshtha is the most important entity when it comes in context with the Panchakarma procedures. Because the treatment as well as its outcome depends upon the type of koshtha one has. Not having knowledge of koshtha leads to various complications. But, assessment of koshtha is tough when it comes to the factors involved in its assessment as well as the factors which influence it. Observing above areas, the knowledge of the standardized factors which help understanding nature of koshtha and helping in assessing it is still a deficient area in terms of research. Hence, this article enlightens the standardize scale for deciding the nature of ones koshtha. Primary Objective (Aim): - To standardize the koshtha before panchakarma procedures. Material & Methods: -The 102 subjects attending the Outpatient department of Panchakarma of our hospital, fulfilling the criteria of inclusion were selected for the present study. Informed consent was taken after explaining the purpose of the study in detail in non-technical terms verbally. Conclusions: Koshtha deciding scale (KDS) is very helpful practically in deciding the nature of koshtha. Koshtha is changing entity unlike prakruti.
MANAGEMENT OF VERRUCOUS EPIDERMAL NEVI WITH KSHARAKARMA: A CASE REPORT
Authors: M Pratap , PS Aswani
Published: August 2023

Verrucous Epidermal Nevi (VEN) are congenital, non-inflammatory cutaneous hamartomas occurring as a result of excessive proliferation of the keratinocytes. Available treatment options are ineffective and recurrences are common. A 66-year-old housewife, presented with complaints of well-defined hypopigmented plaque with verrucous surface on scalp noticed since birth and gradually increasing in size. Initially asymptomatic but since last one year had complaints of itching with loss of patchy hair over the plaque. Incision biopsy taken from the plaque confirmed the case as a verrucous epidermal nevus. The patient was treated with six sittings of Ksharakarma for a period of 3 months. After 3 months of treatment the plaque resolved completely and there was no recurrence noted during 2 years of follow-up. The present case report proves that Ksharakarma, an Ayurvedic parasurgical modality is a better alternative treatment option for VEN.
Evaluation of prognosis of acute colangitis patients via hematological parameters
Authors: Agac Zubeyr , Karaahmetoglu Selma , Akyol Taner
Published: August 2023

Early differentiation of cases with severe acute cholangitis is important for optimal treatment. In this study, it was aimed to elucidate the prognosis with complete blood count parameters among patients with acute cholangitis. Clinical and laboratory findings of 200 patients with acute cholangitis at Ankara City Hospital between February 2019 and October 2019 were retrospectively analyzed. Neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, red cell distribution width and mean platelet volume levels were recorded from blood analysis at the time of admission. According to Tokyo guidelines, patients were divided into 3 groups as mild, moderate and severe acute cholangitis. In order to evaluate the prognosis, the length of hospital stay, the status of hospitalization in the medical intensive care unit and blood culture growth were investigated with hematological parameters. Of the 200 patients, 109 (54.5%) were male and 91 (45.5%) were female. According to Tokyo criteria, 17 patients’ status was evaluated as severe, 70 as moderate and 113 as mild acute cholangitis. The area under the receiver operating characteristics curve for neutrophil-lymphocyte ratio measurements was statistically significant in distinguishing the mild vs moderate disease (AUC=0.694; 95% Confidence Interval (CI):0.586-0.802 and p=0.008), with a diagnostic accuracy rate of 59.5%. The diagnostic accuracy rate of red cell distribution width (AUC=0.603; 95% CI: 0.523-0.683 and p=0.013) was 61.5% and the diagnostic accuracy rate of mean platelet volume (AUC=0.582 95% CI: 0.502-0.662 and p=0.047) was 57.5% achieving a statistical significance. Neutrophil-lymphocyte ratio, red cell distribution width and mean platelet volume analysis is routinely obtained from complete blood count almost in every patient. These are inexpensive and easily accessible diagnostic markers and thus, might be useful in the differentiation of mild and severe acute cholangitis patients and their prognosis.
Prognostic and diagnostic importance of the systemic immune-inflammation index in pediatric head trauma
Authors: Sener Kemal , Cakir Adem , Toksul Halil , Olmez Halil , Tugcan Mustafa , Altug Ertugrul , Guven Ramazan
Published: August 2023

Head trauma is a leading cause of mortality and morbidity in pediatric patients. The trauma itself leads to the activation of a biomolecular cascade of damage. Purinergic receptors and ATP release play an important role in the activation of astroglia, microglia, monocyte-macrophages, neutrophils, and T cells in this process. The systemic immune inflammation index can be easily calculated, cheap, only requires hemogram parameters, and does not include any subjective findings. Therefore, we believe that it could be a prognostic predictor and a diagnostic marker for pediatric head trauma cases. Our study was designed as a retrospective and single-center study. The study was conducted with pediatric patients who presented to the emergency department with isolated head trauma between June 15, 2022, and December 15, 2022. Demographic data, medical history, white blood count, platelet count, neutrophil count, systemic immune inflammation index (SIII), Glasgow Coma Score, and the presence of pathology on brain computed tomography were recorded on the case report form. The study was conducted with 112 cases. In cases with bleeding, the median value of GCS was significantly lower (p<0.001), while WBC, Neutrophil, Platelet, NLR and SIII were significantly higher (p=0.008, p=0.001, p<0.001, p=0.011, and p<0.001, respectively). There was no significant difference between lymphocyte values and bleeding status. We believe that a higher SIII may be associated with persistent pericontusional inflammation in the brain and may be a good marker for predicting intracranial pathology and prognosis of the pathology caused by head trauma.
Neurovascular-derived masses on the digital bundle topographically at the finger
Authors: Sagir Mehmet
Published: August 2023

The arteries supplying the fingers and sensory nerve are located on the radial and ulnar aspects of the fingers, which are called the digital bundle. Masses can be found on this bundle topographically. This study aimed to investigate whether this mass originates from the neurovascular structure in patients presenting with a mass on the digital bundle topographically between the A1 pulley-distal interphalangeal (DIP)/interphalangeal (IP) joint in the finger. Additionally, it aimed to determine whether tumors originating from neurovascular structures originate from the main digital bundle and the steps involved in their reconstruction. We reviewed 27 cases with mass lesions at the digital bundle trace topographically between the A1 pulley and DIP/IP, which underwent surgery and were confirmed by histopathological examination between October 2014 and April 2022. Each patient requested at least two plane radiographs, US and MRI. All patients underwent surgery under a loupe-magnification or microscope. First, we determined whether the mass lesion originated from a main digital artery or nerve. Thereafter, the relationship of the mass with pulley and tendon structures was evaluated. All patients underwent histopathological examination. Mean follow-up 21 months. The mean age was 39.3 years. The pain was the most common presenting complaint and was observed in 13 patients. The tumors originating from neurovascular structures were found in 10 patients. In 5 patients, the tumor originated from the main digital artery and nerve. Three of them were reconstructed with a nerve graft. The most common non-neurovascular tumors were giant cell tendon sheath tumors and epidermal inclusion cysts. Some of the tumors on the topographically digital bundle are of neurovascular in origin. Reconstruction can be made in tumors originating from the main digital bundle. Again, the protection of pulley and tendon structures in this region is important in terms of morbidity.
Measurement of nasal anterior aperture and choana by computed tomography in newborns and infants
Authors: Tasolar Sevgi , Sigirci Ahmet
Published: August 2023

Nasal obstruction is potentially severe when it affects neonates because nasal breathing is predominant during this period. An accurate assessment of nasal airway obstruction should be based on a comparison of the patient's nasal cavity dimensions with precise "normal values". For this reason, we aimed in this study to evaluate the nasal morphometry in newborns and infants with Computed Tomography (CT) in our region. CT images of 134 children who had no facial and cranial anomalies and no pathology were evaluated. In the axial section, the total choana width, right lateral width of the choana, left lateral width of the nasal cavity, the posterior width of the vomer, total aperture width (AW), right aperture width (RAW) and left aperture width were measured in all participants. The study group was divided into 4 age categories: 0-30 days, 31-90 days, 91-180 days and 181-360 days. When the choanal measurements of the groups were evaluated, there was a significant difference between the groups in the choanal measurements (p<0.05, for all), but no difference was observed between the groups in terms of vomer measurements. While there was a significant difference between the groups in terms of AW measurement, there was a significant difference only between Group 1 and Group 4 in terms of RAW value. There was also a positive correlation between age and choanal and aperture values (p<0.05 for all), while no correlation was observed with vomer measurements The normal widths of the choanal and anterior nasal aperture in infants in our region were defined according to months and gender in our study. Considering that there may be social differences, knowing the normative values in normal healthy individuals is of great importance in the evaluation of clinical and pathological conditions.
Evaluation of the vasorelaxant effect of Sugammadex on the arterial smooth muscle in rats
Authors: Karademir Mustafa , Altun Gulsah , Karademir Dilay
Published: August 2023

Although NMBAs (Neuro Muscular Blocking Agents) have been used for a long time, postoperative residual curarization is still a significant problem. Nowadays, an agent named Sugammadex is used for the reversal of curarization. It has been presented as a safer agent than its predecessor, neostigmine. The main purpose of this study is to investigate the effects of Sugammadex on rat thoracic aorta and enlighten the mechanism of action and potential benefits in surgical operations with general anesthesia. Twenty Wistar albino rats were used for the experiments. Thoracic aorta segments have been removed and mounted to the organ bath. Contraction and relaxation responses were presented as a percentage of phenylephrine (3x10-5 M) contraction. After recording contractile responses of Sugammadex (10-8-10-4 M), relaxation responses of Sugammadex (10-8-10-4 M) have been recorded both in the presence and absence of L-NAME (3x10-5 M) (Potent Nitric Oxide Sentase Inhibitor). Finally, relaxation responses of sugammadex-rocuronium have been recorded. Sugammadex caused slightly noticeable and concentration-dependent contraction on isolated thoracic aorta strips. Sugammadex also caused potent and concentration-dependent relaxation on isolated rat thoracic aorta. The relaxation response caused by Sugammadex has been diminished significantly in the presence of L-NAME. Administration of rocuronium with Sugammadex did cause neither relaxation nor any additional contractile effect on isolated rat thoracic aorta strips. Sugammadex is a promising agent in reversing rocuronium-induced neuromuscular block. Although the adverse effects of this agent are not studied in detail, it seems Sugammadex is safer than neostigmine. The side effects of anesthetic agents are one of the main problems of surgical procedures, including neurosurgery, gynecology, and obstetrics. Especially acute hypotension may be fatal in neurosurgery and gynecological operations. Sugammadex should be used carefully in adjusted and individualized doses to avoid hypotension-related adverse effects.
Investigation of the prognostic value of blood parameters in patients with rinoserebral mucormycosis
Authors: Demir Ismail , Yalcin Muhammed , Aydin Sukru , Muluk Nuray , Burulday Veysel
Published: August 2023

Mucormycosis is a rapidly invasive, life-threatening opportunistic fungal infection, usually in immunocompromised patients. Suspicion, early diagnosis, debridement and anti-fungal treatment are important prognostic factors. The most common clinical manifestations of rhinocerebral mucormycosis are fever, headache, facial and ocular oedema. Invasion of surrounding tissues, the eye, skull base and brain is critical for disease progression. The purpose of this study was to investigate the predictive value of blood parameters in patients with mucormycosis. The preoperative 10-day blood parameters of 23 patients with clinical, radiological and pathological diagnoses of mucormycosis were compared in terms of etiology, gender and site of involvement. When the results were compared, the neutrophil-lymphocyte ratio (NLR) on days 1, 2, 5, 7, 8, 9, and 10 was significantly higher in patients with skull base involvement compared to those without skull base involvement (p<0.05). When comparing the regions of involvement, a significant correlation was found between cranial and turbinate involvement and between lamina papricea and ocular involvement (p<0.05). It was suggested that the NLR rate could be predicted as a poor prognostic factor in patients with mucormycosis.
A comparison of veteran athletes and sedentary individuals in terms of dynamic-static balance and cognitive functions
Authors: Kizilay Fatma , Bugday Burak
Published: August 2023

There is strong evidence that being physically active has positive effects on healthy aging, primary and secondary prevention of the development of chronic diseases. The physical and cognitive health benefits of having an active past are less well-known. Therefore, this study aimed to compare veteran athletes with an active sports history with their sedentary peers in terms of balance and cognitive function. Fourteen veteran soccer players and 15 sedentary male volunteers aged between 35-55 years participated in the study. The demographic characteristics of the participants were questioned with a case report form. Participants' balance was evaluated statically and dynamically. Static balance was assessed using the Flamingo test and dynamic balance was assessed with the Y Balance test. The Montreal Cognitive Assessment (MoCA) was used to test cognitive functions. There was no difference between Veteran Athletes (VA) and Sedentary Participants (SP) in terms of static balance test scores with both right and left sides (p>0.05). The results of the VA group were significantly higher (p<0.05) in terms of the total scores of the Y balance test, which consisted of the average of the anterior (ANT), posterolateral (PL), and posteromedial (PM) reaches (p<0.05). In terms of MoCA score, the VA group obtained significantly higher results compared to the SP group (p<0.05). Veteran athletes were found to be superior to same-aged sedentary in terms of dynamic balance and cognitive function. Having an active sporting background can help to mitigate the loss of physical skills such as balance and cognitive functioning that inevitably occurs during the natural aging process. In addition, active old age is also crucial for the preservation of these skills.
A comparative study of the benefits of monotherapy rosiglitazone versus rosiglitazone with insulin in streptozotocin-induced diabetes in rats
Authors: Prabhu Ramesh , Shankarappa Deepak , G Senthil , P Venkata , Kumar Jai
Published: August 2023

Background: Diabetes is often associated with dyslipidemia, where plasma lipid and lipoprotein profile alterations increase the risk of coronary heart disease. Insulin resistance increases the risk of hyperinsulin and atherosclerosis, developing hypertension and diabetes. Patients with diabetes suffer from metabolic disorders in carbohydrates, fat, and proteins associated with hyperglycemia. Hence reducing insulin resistance is a therapeutic approach to treating diabetes.

Aims and Objectives: The aim of the study was to evaluate the beneficial effects of monotherapy rosiglitazone, gemfibrozil, and insulin versus rosiglitazone, gemfibrozil, and insulin combination in streptozotocin-induced diabetes in rats.

Materials and Methods: 42-Wistar rats of either sex were used in this study, except for the control group, streptozocin was used to induce diabetes. These rats were further allocated into five groups, each group consists of eight animals. Blood serum was used to estimate blood glucose and serum lipid levels were observed after a period of 6 weeks. Results were analyzed using SPSS software version 21.0.

Results: Combination therapy of insulin + rosiglitazone + gemfibrozil showed a significant decrease in serum blood glucose, lipid levels in compared with vehicle and rosiglitazone groups.

Conclusion: The results of our study demonstrated a more favorable lipid profile than the monotherapy regimen; adding gemfibrozil and insulin to rosiglitazone could help reverse the cardiovascular adverse events it causes.