bluuebunny/crossref_metadata_2025 huggingface dataset:
Health care expenditures among long-term survivors of pediatric solid tumors: Results from the French Childhood Cancer Survivor Study (FCCSS) and the French network of cancer registries (FRANCIM)
Authors: Bejarano-Quisoboni Daniel , Pelletier-Fleury Nathalie , Allodji Rodrigue S. , Lacour Brigitte , GrosClaude Pascale ,   FRANCIM Group, Pacquement Hélène , Doz François , Berchery Delphine , Pluchart Claire , Bondiau Piere-Yves , Nys Julie , Jackson Angela , Demoor-Goldschmidt Charlotte , Dumas Agnès , Thomas-Teinturier Cécile , Vu-Bezin Giao , Valteau-Couanet Dominique , Haddy Nadia , Fresneau Brice , de Vathaire Florent
Published: May 2022

Background

Childhood cancer survivors (CCS) may require lifelong medical care due to late effects of cancer treatments. Little is known about of their healthcare utilization and expenditures at long-term especially in publicly funded health care system. We aim to estimate and describe the health care expenditures among long-term CCS in France.

Methods

A total of 5319 five-year solid CCS diagnosed before the age of 21 between 1945 and 2000 in France were identified in the French Childhood Cancer Survivors Study cohort (FCCSS) and the French cancer registry. Information about health care expenditure was taken from the French national health data system between 2011 and 2016, and was described according to survivors’ characteristics. Generalized linear models were used to determine associations between health care expenditures and survivors’ characteristics.

Results

Mean annual amount of healthcare expenditures was € 4,255. Expenditures on hospitalizations and pharmacy represents 60% of total expenditures. Mean annual of healthcare expenditures were higher at increasing age, among women survivors (€ 4,795 vs € 3,814 in men) and in central nervous system (CNS) tumor survivors (€ 7,116 vs € 3,366 in lymphoma and € 3,363 in other solid tumor survivors).

Conclusions

Childhood cancer survivorship is associated with a substantial economic burden in France. We found that female gender and CNS primary cancer were associated with increased healthcare expenditures.
Progesterone receptor expression contributes to gemcitabine resistance at higher ECM stiffness in breast cancer cell lines
Authors: Grant Emma , Bucklain Fatma A. , Ginn Lucy , Laity Peter , Ciani Barbara , Bryant Helen E.
Published: May 2022

Chemoresistance poses a great barrier to breast cancer treatment and is thought to correlate with increased matrix stiffness. We developed two-dimensional (2D) polyacrylamide (PAA) and three-dimensional (3D) alginate in vitro models of tissue stiffness that mimic the stiffness of normal breast and breast cancer. We then used these to compare cell viability in response to chemotherapeutic treatment. In both 2D and 3D we observed that breast cancer cell growth and size was increased at a higher stiffness corresponding to tumours compared to normal tissue. When chemotherapeutic response was measured, a specific differential response in cell viability was observed for gemcitabine in 2 of the 7 breast cancer cell lines investigated. MCF7 and T-47D cell lines showed gemcitabine resistance at 4 kPa compared to 500 Pa. These cell lines share a common phenotype of progesterone receptor (PGR) expression and, indeed, pre-treatment with the selective progesterone receptor modulator (SPRM) mifepristone abolished resistance to gemcitabine at high stiffness. Our data reveals that combined treatment with SPRMs may therefore help in reducing resistance to gemcitabine in stiffer breast tumours which are PGR positive.
Evaluation of models for prognosing mortality in critical care patients with COVID-19: First- and second-wave data from a German university hospital
Authors: Kieninger Martin , Dietl Sarah , Sinning Annemarie , Gruber Michael , Gronwald Wolfram , Zeman Florian , Lunz Dirk , Dienemann Thomas , Schmid Stephan , Graf Bernhard , Lubnow Matthias , Müller Thomas , Holzmann Thomas , Salzberger Bernd , Kieninger Bärbel
Published: May 2022

Background

In a previous study, we had investigated the intensive care course of patients with coronavirus disease 2019 (COVID-19) in the first wave in Germany by calculating models for prognosticating in-hospital death with univariable and multivariable regression analysis. This study analyzed if these models were also applicable to patients with COVID-19 in the second wave.

Methods

This retrospective cohort study included 98 critical care patients with COVID-19, who had been treated at the University Medical Center Regensburg, Germany, between October 2020 and February 2021. Data collected for each patient included vital signs, dosage of catecholamines, analgosedation, anticoagulation, and antithrombotic medication, diagnostic blood tests, treatment with extracorporeal membrane oxygenation (ECMO), intensive care scores, ventilator therapy, and pulmonary gas exchange. Using these data, expected mortality was calculated by means of the originally developed mathematical models, thereby testing the models for their applicability to patients in the second wave.

Results

Mortality in the second-wave cohort did not significantly differ from that in the first-wave cohort (41.8% vs. 32.2%, p = 0.151). As in our previous study, individual parameters such as pH of blood or mean arterial pressure (MAP) differed significantly between survivors and non-survivors. In contrast to our previous study, however, survivors and non-survivors in this study showed significant or even highly significant differences in pulmonary gas exchange and ventilator therapy (e.g. mean and minimum values for oxygen saturation and partial pressure of oxygen, mean values for the fraction of inspired oxygen, positive expiratory pressure, tidal volume, and oxygenation ratio). ECMO therapy was more frequently administered than in the first-wave cohort. Calculations of expected mortality by means of the originally developed univariable and multivariable models showed that the use of simple cut-off values for pH, MAP, troponin, or combinations of these parameters resulted in correctly estimated outcome in approximately 75% of patients without ECMO therapy.
Inhaled nitric oxide as temporary respiratory stabilization in patients with COVID-19 related respiratory failure (INOCOV): Study protocol for a randomized controlled trial
Authors: Hagemo Jostein Skjalg , Skulberg Arne Kristian , Rehn Marius , Valberg Morten , Pesonen Maiju , Heimdal Hans Julius , Heyerdahl Fridtjof
Published: May 2022

Background

In March 2020, WHO announced the COVID-19 a pandemic and a major global public health emergency. Mortality from COVID-19 is rapidly increasing globally, with acute respiratory failure as the predominant cause of death. Many patients experience severe hypoxia and life-threatening respiratory failure often requiring mechanical ventilation. To increase safety margins during emergency anaesthesia and rapid sequence intubation (RSI), patients are preoxygenated with a closed facemask with high-flow oxygen and positive end-expiratory pressure (PEEP). Due to the high shunt fraction of deoxygenated blood through the lungs frequently described in COVID-19 however, these measures may be insufficient to avoid harmful hypoxemia. Preoxygenation with inhaled nitric oxide (iNO) potentially reduces the shunt fraction and may thus allow for the necessary margins of safety during RSI.

Methods and design

The INOCOV protocol describes a phase II pharmacological trial of inhaled nitric oxide (iNO) as an adjunct to standard of care with medical oxygen in initial airway and ventilation management of patients with known or suspected COVID-19 in acute respiratory failure. The trial is parallel two-arm, randomized, controlled, blinded trial. The primary outcome measure is the change in oxygen saturation (SpO2), and the null hypothesis is that there is no difference in the change in SpO2 following initiation of iNO.

Trial registration

EudraCT number 2020-001656-18; WHO UTN: U1111-1250-1698.

Protocol version: 2.0 (June 25th, 2021).
Bruins-in-Genomics: Evaluation of the impact of a UCLA undergraduate summer program in computational biology on participating students
Authors: Coller Hilary A. , Beggs Stacey , Andrews Samantha , Maloy Jeff , Chiu Alec , Sankararaman Sriram , Pellegrini Matteo , Freimer Nelson , Johnson Tracy , Papp Jeanette , Eskin Eleazar , Hoffmann Alexander
Published: May 2022

Recruiting, training and retaining scientists in computational biology is necessary to develop a workforce that can lead the quantitative biology revolution. Yet, African-American/Black, Hispanic/Latinx, Native Americans, and women are severely underrepresented in computational biosciences. We established the UCLA Bruins-in-Genomics Summer Research Program to provide training and research experiences in quantitative biology and bioinformatics to undergraduate students with an emphasis on students from backgrounds underrepresented in computational biology. Program assessment was based on number of applicants, alumni surveys and comparison of post-graduate educational choices for participants and a control group of students who were accepted but declined to participate. We hypothesized that participation in the Bruins-in-Genomics program would increase the likelihood that students would pursue post-graduate education in a related field. Our surveys revealed that 75% of Bruins-in-Genomics Summer participants were enrolled in graduate school. Logistic regression analysis revealed that women who participated in the program were significantly more likely to pursue a Ph.D. than a matched control group (group x woman interaction term of p = 0.005). The Bruins-in-Genomics Summer program represents an example of how a combined didactic-research program structure can make computational biology accessible to a wide range of undergraduates and increase participation in quantitative biosciences.
A qualitative study of continence service provision for people living with dementia at home in the UK: Still inadequate?
Authors: Murphy Cathy , De Laine Christine , Macaulay Margaret , Fader Mandy
Published: May 2022

Introduction

Incontinence is a major problem for people with dementia (PWD) and their family/friend caregivers, often causing substantial harm, including residential care admission. The incontinence needs of PWD are complex and different from those of people without dementia.

The aim of this study was to investigate carer and nurse perceptions of continence service provision and potential improvements.

Methods

A secondary analysis of qualitative data was undertaken. Semi-structured interviews (n = 45) were undertaken with PWD, family caregivers and healthcare professionals (continence or dementia nurses) in the UK. PWD and caregivers were recruited viawww.joindementiaresearch.nihr.ac.ukand via dementia/carer groups. Nurses were recruited via their employers. Framework analysis was used. The COREQ Research guideline statement assists reporting.

Results

Four themes were found. Firstly, there was a lack of awareness of the service and waiting time. Many caregivers were unaware of continence services and dementia nurses often viewed it as a pad provision service. Caregivers reported long waits not meeting their urgent needs. Secondly, product provision was often inadequate. Most caregivers self-purchased all or many products and substantial variation in product provision was found. The number of products provided was often inadequate. Thirdly, a sense that “nothing can be done” was observed by some nurses and caregivers. Caregivers believed that, if nothing else, care information should be provided. Finally, suggestions for improvements were made, including proactive service signposting, joint clinics with dementia services, improved information before crisis point, dementia training for continence nurses and improved product provision.

Conclusion

Continence service inadequacies for PWD and caregivers have been reported for many years. This study demonstrates service provision remains unsatisfactory in the UK. Stakeholders propose a range of service improvements. It highlights that listening to the voices of PWD, caregivers and nurses is crucial for services seeking to improve continence services for PWD living at home.
Diarrhoeagenic E. coli occurrence and antimicrobial resistance of Extended Spectrum Beta-Lactamases isolated from diarrhoea patients attending health facilities in Accra, Ghana
Authors: Dela Helena , Egyir Beverly , Majekodunmi Ayodele O. , Behene Eric , Yeboah Clara , Ackah Dominic , Bongo Richard N. A. , Bonfoh Bassirou , Zinsstag Jakob , Bimi Langbong , Addo Kennedy Kwasi
Published: May 2022

Introduction

Diarrhoea accounts for high morbidity and mortality in children and adults worldwide. Extended Spectrum Beta-Lactamase-Producing Enterobacteriaceae (ESBL-PE) and Diarrhoeagenic Escherichia coli (DEC) contribute to prolonged hospitalization because of their resistance and virulence properties aiding in the spread of diarrhoeal disease and delayed treatment.

Aim

To determine DEC and the antimicrobial resistance of ESBL-PE isolated among diarrhoea patients attending two health facilities in Ghana.

Methods

Stool samples were collected from 122 diarrhoeal patients who attended Maamobi General Hospital and Kaneshie Polyclinic between January 2019 and March 2020. Identification of bacteria was performed by using the Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). Using disk diffusion, antimicrobial susceptibility testing (AST) was conducted and interpreted according to the 2018 CLSI guidelines. Detection of ESBL and DEC genes was performed using Polymerase chain reaction (PCR).

Results

A total of 80.3% (98/122) Enterobacteriaceae was recovered from the patients in the study with an overall ESBL occurrence of 20.4% (20/98), predominantly among E. coli showed 13.2% (10/76), Klebsiella pneumoniae,35.7%(5/14) and Proteus mirabilis, 57.1%(4/7). Among the ESBL genes detected, blaTEM (n = 14) was common, followed by blaCTX-M (n = 13) and blaSHV (n = 4). Thirty-four E. coli isolates possessed the heat labile (Lt) gene of Enterotoxigenic E. coli (ETEC).

Conclusion

Our findings confirm the existence of DEC and the antimicrobial resistance patterns of ESBL-PE among stool isolates, limiting the options of commonly used drugs for diarrhoeal treatment in Ghana. Routine laboratory testing in health care facilities and strengthened surveillance systems among hospital networks are encouraged for a better understanding of their epidemiology and clinical implications.
Recent and historical data show no evidence of Pacific bluefin tuna reproduction in the southern California Current system
Authors: Dewar Heidi , Snodgrass Owyn E. , Muhling Barbara A. , Schaefer Kurt M.
Published: May 2022

Despite their broad distribution across the North Pacific Ocean, the only known spawning grounds for Pacific Bluefin Tuna (Thunnus orientalis) are around coastal Japan and the East China Sea. However, an increase in the prevalence of large bluefin tuna up to 10 years old in the California Current System during exceptionally warm ocean conditions has led to speculation that they may be spawning in this region. To investigate this possibility, we collected samples from 36 females (estimated 3–8 years old) between 2015 and 2019. Histological analyses revealed no signs of imminent, active, or recent spawning. Further examination of historical ichthyoplankton collections showed no records of larval bluefin tuna, but confirmed the presence of the larvae of other tuna species in waters > 24°C. Fishery-dependent records showed that bluefin tuna are rarely recorded in purse seine catches where surface temperatures exceed 23°C. Our study, therefore, provided no evidence of bluefin tuna reproduction in the CCS. However, more comprehensive sampling, in particular off southern Baja California, may be required to confirm the absence of spawning.
Sex differences in outcomes from mild traumatic brain injury eight years post-injury
Authors: Starkey Nicola Jayne , Duffy Brittney , Jones Kelly , Theadom Alice , Barker-Collo Suzanne , Feigin Valery ,   on behalf of the BIONIC8 Research Group
Published: May 2022

The long-term effects of mild TBI (mTBI) are not well understood, and there is an ongoing debate about whether there are sex differences in outcomes following mTBI. This study examined i) symptom burden and functional outcomes at 8-years post-injury in males and females following mTBI; ii) sex differences in outcomes at 8-years post-injury for those aged <45 years and ≥45 years and; iii) sex differences in outcomes for single and repetitive TBI. Adults (≥16 years at injury) identified as part of a population-based TBI incidence study (BIONIC) who experienced mTBI 8-years ago (N = 151) and a TBI-free sample (N = 151) completed self-report measures of symptoms and symptom burden (Rivermead Post-Concussion Symptom Questionnaire, Hospital Anxiety and Depression Scale, Post-traumatic Stress Disorder Checklist), and functional outcomes (Participation Assessments with Recombined Tools, Work Limitations Questionnaire). The mTBI group reported significantly greater post-concussion symptoms compared to the TBI-free group (F(1,298) = 26.84, p<.01, ηp2 = .08). Females with mTBI were twice as likely to exceed clinical cut-offs for post-concussive (X2 (1)>5.2, p<.05, V>.19) and PTSD symptoms (X2(1) = 6.10, p = .014, V = .20) compared to the other groups, and reported their health had the greatest impact on time-related work demands (F(1,171) = 4.36, p = .04, ηp2 = .03. There was no interaction between sex and age on outcomes. The repetitive mTBI group reported significantly greater post-concussion symptoms (F(1,147) = 9.80, p<.01, ηp2 = .06) compared to the single mTBI group. Twice the proportion of women with repetitive mTBI exceeded the clinical cut-offs for post-concussive (X2(1)>6.90, p<.01, V>.30), anxiety (X2(1)>3.95, p<.05, V>.23) and PTSD symptoms (X2(1)>5.11, p<.02, V>.26) compared with males with repetitive TBI or women with single TBI. Thus, at 8-years post-mTBI, people continued to report a high symptom burden. Women with mTBI, particularly those with a history of repetitive mTBI, had the greatest symptom burden and were most likely to have symptoms of clinical significance. When treating mTBI it is important to assess TBI history, particularly in women. This may help identify those at greatest risk of poor long-term outcomes to direct early treatment and intervention.
SARS-CoV-2-specific T cells associate with inflammation and reduced lung function in pulmonary post-acute sequalae of SARS-CoV-2
Authors: Littlefield Katherine M. , Watson Renée O. , Schneider Jennifer M. , Neff Charles P. , Yamada Eiko , Zhang Min , Campbell Thomas B. , Falta Michael T. , Jolley Sarah E. , Fontenot Andrew P. , Palmer Brent E.
Published: May 2022

As of January 2022, at least 60 million individuals are estimated to develop post-acute sequelae of SARS-CoV-2 (PASC) after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While elevated levels of SARS-CoV-2-specific T cells have been observed in non-specific PASC, little is known about their impact on pulmonary function which is compromised in the majority of these individuals. This study compares frequencies of SARS-CoV-2-specific T cells and inflammatory markers with lung function in participants with pulmonary PASC and resolved COVID-19 (RC). Compared to RC, participants with respiratory PASC had between 6- and 105-fold higher frequencies of IFN-γ- and TNF-α-producing SARS-CoV-2-specific CD4+ and CD8+ T cells in peripheral blood, and elevated levels of plasma CRP and IL-6. Importantly, in PASC participants the frequency of TNF-α-producing SARS-CoV-2-specific CD4+ and CD8+ T cells, which exhibited the highest levels of Ki67 indicating they were activity dividing, correlated positively with plasma IL-6 and negatively with measures of lung function, including forced expiratory volume in one second (FEV1), while increased frequencies of IFN-γ-producing SARS-CoV-2-specific T cells associated with prolonged dyspnea. Statistical analyses stratified by age, number of comorbidities and hospitalization status demonstrated that none of these factors affect differences in the frequency of SARS-CoV-2 T cells and plasma IL-6 levels measured between PASC and RC cohorts. Taken together, these findings demonstrate elevated frequencies of SARS-CoV-2-specific T cells in individuals with pulmonary PASC are associated with increased systemic inflammation and decreased lung function, suggesting that SARS-CoV-2-specific T cells contribute to lingering pulmonary symptoms. These findings also provide mechanistic insight on the pathophysiology of PASC that can inform development of potential treatments to reduce symptom burden.
Only anecdotal: Diane Williams, loneliness and short story form
Authors: Reese Sam
Published: May 2022

Traditionally, the short story has been understood as almost synonymous with loneliness, characterized by theorists and writers like Frank O’Connor as the quintessential ‘lonely form’. Contemporary short story writer Diane Williams stands out for her idiosyncratic challenge to the conventions of short story structure, drawing deliberately on the partiality and contingency of the anecdote. Analysing the structure and style of collection Fine, Fine, Fine, Fine, Fine, this article explores how a turn to anecdotal structures might shift the short story form’s traditional polarity towards loneliness – a particularly urgent question in an increasingly lonely culture.
‘Gate Five’
Authors: Freund Nancy
Published: May 2022

The first full day of it, emergency room admittance to the bed he died in four days later, all I could think to say was, ‘Dad, I’m here’. And then somehow, I was granted more. Something fuller, more creative, and infinitely better. This is what a writer hopes for. A daughter. A human being. A fragile baby soul emerging, in utero, as it were. We wish for the words and humility to say them – voiced or penned – and the miraculous understanding that their expression is received. Their intention is fulfilled, at least to some extent, and that pain’s at bay, even if only for a moment.
Design principles for music technology education support: Just-in-time learning in the recording studio using mobile technologies
Authors: Voss Brett
Published: May 2022

Popular music education involves engaging students with using a range of music technologies found in recording studios, through utilization of multiple hardware and software devices to enable the recording process. Student users can struggle to keep up with the volume of knowledge required to operate these environments to their full potential. Providing just-in-time learning resources to support these students could improve student learning through augmenting gaps in their knowledge. Just-in-time learning is the provision of active learning opportunities that engage learners with skill development as part of the working process. This approach to supporting music technology education was trialled within a programme teaching popular music. The research found that students welcomed the provision of just-in-time learning opportunities delivered through a mobile phone application and that this suited their learning approach in the recording studio. This article suggests that mobile learning resources can benefit the curriculum of programmes working with music technology. The study was conducted using a design-based research methodology with students within a conservatorium teaching popular music. This popular music programme heavily utilized the recording studio as a learning and teaching tool, requiring students to engage with music technology routinely. Thirty students from all year levels of the undergraduate programme participated in the research project through surveys and focus groups. The research involved iterative cycles of mobile application design and testing over an eighteen-month period. Previously, a pilot study identified that students felt that on-demand learning opportunities delivered through mobile devices would be beneficial to their learning. The research from the design and testing of the mobile application evolved a series of design principles, which could be used as a guide for developing just-in-time resources to support music technology education.
Rendering life: Transgressive affinities between bio art and generative art
Authors: Grba Dejan , Todorović Vladimir
Published: May 2022

In this article, we trace the analogies, parallels and affinities between bio-inspired generative art and bio art practices with strong generative flavour. We look at the creative and expressive features in these two fields, compare their shared interests in the design and development of life, and discuss the strategies they apply to communicate and engage the audience. With respect to the existing literature, which relates bio and generative art primarily within a historical context, we compare these two fields focusing on generativity as their common poetic driver. We indicate their shared impetus for rendering distinctive visions of nature in order to identify, contemplate or provoke dramatic changes in the era when biological processes become programmable and living matter can be instrumentalized for various forms of labour. We also examine the epistemological and practical effectiveness of the two fields within a broader socio-technical perspective, which leads us to their constructive critique.
Deconstructing the isolated astronaut-artist paradigm
Authors: Bardakos Ioannis , Sourgiadaki Eirini , Lioret Alain
Published: May 2022

In the context of a viral outbreak and necessary physical distancing, the emergence of new or the evolution of older artistic behavioural schemes becomes evident. We correlate the isolation space of the artist with the cockpit of a spaceship and the navigation and communication interfaces used by an astronaut. The cybernetic domain between physical space(s) and artist(s) can be thought of as consisting of many ‘organs’. It includes a core (black box), many-layered limits: skin, walls, mental and digital borders as well as mechanisms of connectivity with external entities (other astronauts in art spaceships). This space could be a bedroom, a studio, an office or any different location the artist uses as an isolated bubble of information sharing and manipulation (material and immaterial). For the construction of such an (astronaut, artist) ontology we use metaphors, etymological references, transformed concepts and creative analogies between the actual and the subjective space. As one case study for this paradigm, we experimented with a telematic performance of Heiner Müller’s Hamlet Machine titled, I want to be 171.
The edge of life-as-we-know-it: Aesthetics of decay within artificial life and art
Authors: Greenfield Remina , Cao Shuyi
Published: May 2022

This article advocates further examination of the role decay aesthetics can play in artificial life (ALife or AL) and art. Opening with the poetics of decay and the shadow that decay taboo has cast in western culture, firstly, we reframe decay as a constructive process of transformation. Secondly, we perform a brief historical survey of early artistic developments in the field of ALife, assessing how these early works addressed decay. We follow with a deeper analysis of contemporary artists through a lens of decay and decomposition, identifying new tendencies of ALife art (deep time simulation, slime intelligence, molecular agents, techno resurrection and ecohybridized computation). Finally, we look to the peripheries of ALife to see how decay is rendered in current technical research and examine these projects with an eye for turbulent production in the form of ‘decaying’ matter. We conclude with a number of open questions on decomposition and decay aesthetics, both within the artistic and technical realms of ALife.
Mercato cambiario e uomini d’affari a Barcellona durante la guerra tra Alfonso il Magnanimo e la Repubblica Fiorentina
Authors: Maccioni Elena
Published: May 2022

La metà del secolo XV fu per la Corona d’Aragona e specialmente per Barcellona un periodo complicato: Alfonso V era impegnato nelle guerre italiane, in particolare contro Firenze e Milano, Genova e Venezia; il Regno di Napoli era stato annesso all’Unione, e richiedeva sforzi importanti per il suo mantenimento; allo stesso tempo dalla capitale catalana provenivano richieste di apertura “democratica” del Consiglio dei Cento, che portavano a un’evidente instabilità interna, frutto in parte di una dimostrata crisi monetaria, dovuta anche alla scarsa capacità di governo dell’economia. Nonostante ciò, i mercanti, gli armatori e i banchieri continuarono a cercare di portare avanti i propri interessi economici nel Mediterraneo, anche servendosi delle istituzioni di natura corporativa, come il Consolato del mare. Attraverso l’analisi di alcuni registri di protesti di lettere di cambio gestiti dal notaio del Consolato barcellonese, si cercherà di mettere in luce l’evoluzione delle reti mercantili-finanziarie catalane, in particolare lungo la rotta meridionale italiana. Lo studio non avrà l’obiettivo di analizzare l’uso tecnico dello strumento cambiario, ma quello di portare alla luce strategie e protagonisti del processo di inserimento del capitale mercantile e finanziario in Italia durante il regno di Alfonso il Magnanimo e in special modo durante la guerra contro Firenze. Emergeranno, così, i nomi di quelle persone che furono le protagoniste dei grandi e quotidiani spostamenti di denaro fra i centri politico-commerciali del Commonwealth catalanoaragonese. Si tenterà una prima ricostruzione delle loro attività e dei loro movimenti, nonché delle connessioni con i più importanti operatori del sistema finanziario europeo, ovvero i toscani.
Des corsaires castillans à Marseille: mercenaires de la mer ou acteurs du commerce méditerranéen (XIVe et XVe siècles)?
Authors: Gouffran Laure-Hélène Théodora
Published: May 2022

À partir de la fin du XIVe siècle, la présence à Marseille de corsaires venus de la Couronne de Castille apparaît de plus en plus importante dans les archives provençales. Ceux que les documents notariés appellent « yspani » profitent des guerres menées par les souverains angevins ainsi que du conflit qui oppose après 1423 la Provence à la Couronne d’Aragon pour venir prêter leurs services aux rois de la seconde maison d’Anjou et au gouvernement urbain de Marseille. En s’appuyant sur un corpus documentaire inédit provenant des archives municipales de Marseille et des archives départementales des Bouches-du-Rhône, cet article s'interroge sur la place et le rôle de ces hommes dans le contexte marseillais des années 1380-1430. À travers quatre trajectoires singulières, il est possible d’identifier deux « modèles » de corsaires : d’une part les grands mercenaires castillans qui s’engagent auprès des souverains et auprès du pape et qui peuvent être considérés comme des experts de la guerre maritime et, de l’autre, des patrons de navires qui exercent également comme marchands et qui profitent après 1423 des opportunités commerciales fournies par une ville en guerre pour venir s’installer à Marseille. Par leurs mobilités et par les liens profonds qu’ils entretiennent avec les cités, ces corsaires peuvent être considérés comme des acteurs de la connectivité méditerranéenne.
Narbona Vizcaíno, R., Bernabeu Borja, S. (2021). Prohoms i cavallers de València. El Consell (1306-1516). València: Publicacions Universitat de València. 1080 pp. ISBN: 978-84-9133-373-9
Authors: Barrio Barrio Juan Antonio
Published: May 2022

Reseña: Narbona Vizcaíno, R., Bernabeu Borja, S. (2021). Prohoms i cavallers de València. El Consell (1306-1516). València: Publicacions Universitat de València. 1080 pp. ISBN: 978-84-9133-373-9
Experiências Formativas não Escolares: História & Teoria da Educação
Authors: Dentz Schirlei Russi von
Published: May 2022

A proposta do ebook “Experiências formativas não escolares: história & teoria da Educação”, lançado em 2021, é colocar em evidência outras instituições que promovem a educação não legitimada, como é o caso da instituição escolar, mas que contribuem para a formação dos indivíduos, das suas subjetividades. Essas outras instituições são: o Estado, a medicina, o meio de comunicação jornalístico impresso, os livros, instituições religiosas, o meio social, como a família, a vizinhança etc. O ebook está dividido em três partes, com sete capítulos, onde os autores/pesquisadores corroboraram com a temática principal de pensar a educação e sua história a partir de lugares comuns, ou seja, fora da escola. Organizado pelo historiador, pesquisador e professor Matheus da Cruz e Zica, que tem estudado a “formação” dos indivíduos nos mais diferentes espaços, este ebook apresenta justamente este aspecto formativo das subjetividades em lugares inimaginados.
Museu Pedagógico Nacional – Pedagogium, uma vitrine comercial (Rio de Janeiro, Brasil / 1890-1919)
Authors: Silva Camila Marchi da
Published: May 2022

O Museu Pedagógico Nacional – Pedagogium foi fundado em 1890 e funcionou até 1919, na cidade do Rio de Janeiro. Estabelecido pelo Decreto nº 981, era função da instituição oferecer ao público e aos professores os meios de instrução profissional, a exposição dos melhores métodos e material de ensino inovador, disponibilizando formações de diferentes tipos. Sabe-se de uma parcela da história dessa instituição como centro de formação de professores, porém, além disso, a história dos museus pedagógicos está intimamente ligada às Exposições Universais, já que eles seriam centros difusores de tecnologias educacionais; não raro, museus pedagógicos poderiam ser formados a partir do que era apresentado em exposições. Esta publicação tem por objetivo apresentar variadas facetas entre o Pedagogium e suas relações com feiras universais, comerciais e museus, bem como compreender e analisar a constituição do acervo do Pedagogium, levando em conta as suas afinidades com o comércio e a indústria.
Despesas com pessoal e dívida consolidada líquida nos municípios do estado de Santa Catarina pós lei de responsabilidade fiscal
Authors: De Oliveira Guilherme , Varela Jorge Karina , Prado Souza Eduardo
Published: May 2022

O panorama das finanças públicas no Brasil se deteriorou rapidamente após 2014, mesmo diante de regras fiscais rígidas como aquelas impostas pela Lei da Responsabilidade Fiscal (LRF). Este estudo examina a trajetória dos gastos com pessoal e endividamento público nos municípios catarinenses pós Lei de Responsabilidade Fiscal. A análise foi realizada por meio da utilização de um estimador de densidades de núcleo (Kernel). Os resultados sugerem que apesar do controle do endividamento, a LRF criou um incentivo à elevação das despesas com pessoal, aumentando a rigidez orçamentária. Nesse cenário, o investimento público municipal tornou-se a principal variável acomodativa de choques recessivos.
Barreiras não-tarifárias no comércio internacional: estudo bibliométrico em periódicos científicos entre 1966 e 2018
Authors: Mendes Krisley , Garcia Cândido Tiago , De Sousa Marinho Matheus , De Moura Ponte Darlan
Published: May 2022

No Brasil, a escassez de estudos sobre barreiras não-tarifárias (BNTs) sugere desarticulação da comunidade científica nacional à produção internacional. Este trabalho mapeia a comunidade científica que estuda BNTs. A metodologia utilizou-se das técnicas da bibliometria e de suas leis básicas: Lotka, Bradford e Zipf. Os resultados destacam os principais pesquisadores, países, universidades e instituições que sediam essas pesquisas, os periódicos que mais publicam e as palavras-chave mais utilizadas. O trabalho contribui para oferecer compreensão sobre o atual estágio de desenvolvimento científico sobre BNTs e auxilia o planejamento de novas pesquisas.
Análise da competitividade internacional do petróleo brasileiro e venezuelano destinado a China
Authors: Lana Pinto Victor Henrique , Ribeiro Teodoro Nathany Ohana
Published: May 2022

Este artigo investiga a competitividade do petróleo brasileiro e venezuelano destinado a China entre 2007 e 2017. Para isso, utilizou-se o Indicador de Vantagens Comparativas Reveladas (IVCR), o Índice de Orientação Regional (IOR) e o Coeficiente de Dependência de Importações (CDI). O IVCR mostrou que as exportações venezuelanas de petróleo foram mais competitivas que as brasileiras. O IOR indicou que as exportações de petróleo brasileiras foram mais orientadas para a China do que as Venezuelanas. O CDI demonstrou que as importações chinesas de petróleo da Venezuela tiveram maior impacto sobre seu PIB do que as importações chinesas de petróleo brasileiro.
Política fiscal e recessão econômica em Minas Gerais: uma análise dos resultados fiscais estruturais e dos impulsos fiscais entre 2013 e 2017
Authors: Braga Góes Arhtur , Seixas Barbosa Lúcio Otávio
Published: May 2022

O presente artigo analisa a condução da política fiscal pelo Governo do Estado de Minas Gerais durante a recessão econômica brasileira compreendida entre 2014 e 2016. A metodologia utilizada envolve o cálculo dos resultados estruturais e impulsos fiscais, adaptando-a para as especificidades do estado mineiro. O período de análise compreende os anos de 2013 a 2017. Os resultados evidenciam as dificuldades em conter o avanço das despesas com pessoal no âmbito estadual e sugerem que existe pouca margem para políticas contracíclicas, registrando-se impulsos contracionistas mesmo durante a recessão.
Cadê o juízo do Menino?
Authors: Pegoraro Camile , Silva Eduardo Cristiano Hass da , Copatti Raquel Pegoraro
Published: May 2022

O artigo é originário de uma pesquisa empírica com crianças de 10 e 11 anos, estudantes de uma escola localizada na periferia da cidade de Porto Alegre/RS. A investigação se propõe a analisar as concepções infantis acerca do conceito de normalidade a partir do livro Cadê o Juízo do Menino?, parte das obras do Plano Nacional pela Alfabetização na Idade Certa (PNAIC). A obra foi lida e discutida com alunas e alunos, a partir da realização de rodas de conversas. As análises aqui realizadas articulam os textos escrito e visual da obra, a legislação e as reflexões das crianças. Recorremos ao conceito de Atuação das Políticas Educacionais (BALL; MAGUIRE; BRAUN, 2006) para analisar o material empírico produzido. Os resultados apontam que as políticas de educação vão além dos seus objetivos educacionais ou pedagógicos, como a alfabetização e o letramento, mas também contribuem para a formação humana dos/as estudantes. Por isso, a interferência das/dos educadoras/es é fundamental, desde a escolha das obras lidas em cada sala de aula até o debate acerca delas, contribuindo para rever estereótipos e proporcionar uma educação crítica.
Candidíase vulvovaginal
Authors: Barbosa Nathállia Resende de Melo , Lima Rodrigo Fonseca , Galato Dayani , Machado Alexandre Vaz
Published: May 2022

Este trabalho busca descrever as ações de promoção à saúde da mulher no âmbito da Atenção Primária à Saúde (APS) em uma Unidade Básica de Saúde (UBS) do Distrito Federal. Trata-se de um estudo observacional transversal desenvolvido por meio de entrevista com médicos e enfermeiros da UBS. Os profissionais de saúde participantes da pesquisa tinham experiência média de cinco anos e seis meses na APS. A maioria referiu abordar ações voltadas à saúde da mulher em suas equipes e diagnosticar frequentemente a candidíase vulvovaginal, principalmente pela demanda espontânea. Como causas principais da doença foram citadas a higiene íntima, o tipo de vestimenta das pacientes e o estresse. A educação em saúde foi exemplificada como conduta frente ao diagnóstico e como ação para redução dos casos. O estudo pôde reforçar a importância das atividades trabalhadas com grupos estratégicos na estratégia saúde da família, a partir de reflexões sobre a educação em saúde e a autonomia da mulher à frente da sua qualidade de vida e bem-estar.
Breve histórico da Educação Integral no Brasil numa perspectiva crítica
Authors: Guimarães Adonile Ancelmo
Published: May 2022

Este artigo é um estudo teórico que pretende analisar a bibliografia sobre a Educação Integral no Brasil, no que diz respeito às suas concepções surgidas ao longo da história. O intuito é tecer alguns posicionamentos sobre as discussões e problemas levantados a partir da pesquisa. Partimos do pressuposto de que o entendimento sobre a Educação Integral foi se alterando conforme as experiências e os modelos ao longo dos anos e compreender como isso aconteceu é um dos objetivos deste trabalho. Ao analisarmos a documentação sobre a Educação Integral no Brasil, deparamo-nos com experiências regionais e nacionais, que nos permitiram contextualizar e jogar luz à própria compreensão de Educação Integral e suas especificidades no território brasileiro. Muitas dessas experiências nos mostraram que a Educação Integral foi implantada no Brasil com objetivos mais assistencialistas do que educacionais. Trazer à tona o contexto dessas experiências pode nos ajudar a compreender alguns dos problemas atuais da educação brasileira.
Precedente Judicial como Ferramenta de Combate à Padronização Decisória no novo Código de Processo Civil
Authors: Bernardi Bidinotto Vanessa de Oliveira , Nunes Martins Rita de Cássia
Published: May 2022

O presente trabalho tem como objetivo analisar a padronização decisória no Brasil através de um comparativo entre os principais sistemas jurídicos, quais sejam o common law e o civil law. Para tanto, o estudo será dividido em três partes, sendo a primeira o estudo dos dois principais sistemas jurídicos, quais sejam o common law e o civil law, após será feita uma comparação do sistema jurídico do Brasil com o common law, para, por fim, analisar a questão da adoção de precedentes pelo judiciário brasileiro. Assim, o estudo perpassa pela análise dos sistemas, para, após, demonstrar o fenômeno da commonlização do civil law que vem ocorrendo no direito brasileiro. Na sequência será feita uma diferenciação entre jurisprudência e precedente, bem como um estudo acerca da adoção de um caminho reconstrutivo do sistema jurídico atual brasileiro, cujo objetivo seja dar unidade ao Direito e respeitar os princípios constitucionais da segurança jurídica, liberdade e igualdade na seara do Código de Processo Civil brasileiro.
Impacto das Fake News na Democracia e o Papel da Cláusula Democrática
Authors: Sanches Wünsch Marina , Alves Ferreira Natasha
Published: May 2022

O desenvolvimento da tecnologia e da internet provocou uma revolução tecnológica, diminuindo as distâncias, incrementando a comunicação e a disseminação do conhecimento. Também não se pode negar as facilidades que esses avanços trouxeram para um mundo globalizado, como a possibilidade de comunicações instantâneas, entre outras vantagens. O presente artigo pretende analisar de que forma as Fakes News podem ser/são um novo instrumento de ruptura da democracia na América Latina. Para tanto, parte da hipótese de que as Fakes News são uma nova forma de ameaça à democracia, na medida em que promove uma desinformação entre a população, influenciando no pleno exercício dos direitos políticos e na realização de eleições livres e justas. Além disso, discute a possibilidade de aplicação da cláusula democrática da OEA, enquanto um instrumento de resposta para novas formas de ruptura democrática. A metodologia da pesquisa se assenta no método hipotético dedutivo.
Aspectos da Exceção no Direito Internacional, de Nathalia França
Authors: Abrantes Vinicius Villani
Published: May 2022

Trata-se de uma resenha do livro “Aspectos da Exceção no Direito Internacional”, escrito pela pesquisadora e professora Nathalia P. C. de França, e publicado pela Editora Contracorrente, em 2021. A obra, dividida em quatro capítulos, é resultado do estudo defendido no Programa de Pós-graduação da Pontifícia Universidade Católica de São Paulo, sob orientação do Professor Pedro Estevam Alves Pinto Serrano, tendo com objetivo geral apresentar e debater a existência das medidas de exceção no cenário internacional.
Violência Doméstica Contra a Mulher
Authors: Gonçalves Caldeira Wanessa , Aparecida da Silva Franchi Rosângela , Diniz Garcia Naiara
Published: May 2022

Este trabalho tem como objetivo expor a situação vivenciada pela mulher em seu ambiente doméstico, no que se refere às inúmeras e constantes agressões provocadas pelo parceiro (a) íntimo (a), analisando-se, em especial, os casos ocorridos no estado de Minas Gerais, no Brasil. Com o advento da pandemia provocada pela COVID-19, percebeu-se um aumento significativo nos casos de violência doméstica contra a mulher, o que também se tornou tema do presente estudo. Trata-se de um problema histórico, social e arraigado na cultura brasileira, em que, por muitas vezes, a mulher, vítima de tal fato, sofre calada, sem realizar a devida denúncia por medo, vergonha, submissão, dependência, entre outros fatores, o que gera uma considerável subnotificação nos casos. A Lei n. 11.340, de 07 de agosto de 2006, popularmente conhecida como Lei Maria da Penha, foi consagrada como um verdadeiro marco de proteção à mulher, apresentando diversos mecanismos na tentativa de coibir tal ato. Várias são as formas de violência enfrentada pela mulher, o que resulta em consequências de ordem física, psicológica e moral. As causas de tal submissão também são diversas, o que abrange muitas vezes, o medo, a dependência financeira e a esperança de uma prometida mudança. Tal estudo, realizado por meio de pesquisa bibliográfica, justifica-se devido à importância de se conhecer os reais números da violência contra a mulher, e entender os seus motivos, as causas e as consequências desse inaceitável ato.
Usos dos recursos hídricos subterrâneos na Circunscrição Hidrográfica do Entorno do Reservatório de Furnas
Authors: Deus Franciny Oliveira , Latuf Marcelo Oliveira
Published: May 2022

Nas últimas décadas vem ocorrendo a intensificação do uso de recursos hídricos no atendimento à diversas demandas da sociedade e, neste viés, a água subterrânea vem sendo utilizada com maior frequência e volume, visto à menor influência de variações meteorológicas em sua disponibilidade. Por outro lado, a captação da água subterrânea é mais onerosa, quando comparada à água superficial, já que depende de levantamentos geológicos para sua utilização. No entorno do reservatório de Furnas, localizado no Sul do Estado de Minas Gerais, destacam-se demandas pelo uso dos recursos hídricos subterrâneos tais como irrigação, indústria, consumo humano dentre outros. Nesse sentido, o estudo almeja compreender a dinâmica espaço-temporal das outorgas subterrâneas deferidas na Circunscrição Hidrográfica do Entorno do reservatório de Furnas no período de 2001 a 2020, a fim de subsidiar ações de suporte à decisão aos órgãos gestores nas diversas esferas administrativas. Para tal, utilizou-se dados de outorgas subterrâneas do Instituto Mineiro de Gestão das Águas, onde foram processados por meio de planilhas eletrônicas e técnicas de estatística descritiva. Por outro lado, recorreu-se ao Sistema de Informação Geográfica para a obtenção de superfícies contínuas de densidade de outorgas deferidas, bem como de vazões consumidas. Resultados demonstram que 624 outorgas subterrâneas foram deferidas na área de estudo entre os anos de 2001 e 2020 e que, a partir do ano de 2013, ocorreu um incremento expressivo no quantitativo outorgado, sendo que os segmentos usuários que tiveram as maiores demandas foram o abastecimento público/consumo humano e a irrigação/consumo agroindustrial, respectivamente. Nessa conjuntura, é fundamental que o órgão gestor, bem como o Comitê de Bacia Hidrográfica do Entorno do Reservatório de Furnas, realizem o planejamento e o gerenciamento em relação aos recursos hídricos subterrâneos, a fim de evitar futuros cenários de conflitos pelos usos múltiplos das águas subterrâneas.