bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of histopathological outcomes HPV testing in urine and cervical samples.
Authors: Kazanci Ferah , Erdem Ozlem , Bozdayi Gulendam , Onan M. Anil
Published: July 2023

Objective: The goal of cervical screening is to identify and
treat high grade cervical intraepithelial neoplasia (HSIL), in order to
reduce the incidence of the cancer. The objective of this investigation
was to analyze the sensitivity and detection rate of HSIL in urine
samples from those who tested status for HPV, as well as to assess and
contrast the histopathological findings of HPV-positive individuals in
cervical and urine specimens. Materials and Methods: This study
comprised 151 patients who had previously tested positive for HPV in
their cervical samples. The commercial real-time PCR techniques via
Roche Cobas Test were used for identification and genotyping HPV in
urine specimens. The examination of cytological and histological samples
evaluated according to Bethesda criteria and LAST PROJECT.
Results: HPV types 16, 18, and/or together OHR 100% and 80%
were present in HSIL cases in cervical and urine samples, respectively.
Urine samples had a sensitivity of 85.7% and a specificity of 32.7%
for detecting HSIL/CIN2 lesions, and a sensitivity of 83.3% and a
specificity of 36.1% for detecting HSIL/CIN3 lesions. Individuals with
HPV-positive urine had a sensitivity and specificity of 74% and 46.2%,
respectively, for identifying persistent infection. Conclusion:
HPV positivity was not detected in all urine samples due to the lack of
a standardized tool. However, urine HR-HPV screening has a high
sensitivity to determining the presence of high-grade lesions.
Furthermore, urine HR-HPV screening may be used as a predictive tool for
the persistence of HPV infection.
The Generalized Alpha Power Exponentiated Inverse Exponential distribution and it's application to real data
Authors: Kargbo Moses , Waititu Anthony , Wanjoya Anthony
Published: July 2023

This paper proposes a new distribution named “The Generalized Alpha
Power Exponentiated Inverse Exponential (GAPEIEx for short)
distribution” with four parameters, from which one (1) scale and three
(3) shape parameters and the statistical properties such as Survival
function, Hazard function, Quantile function, r^(th) Moment, Rényi
Entropy, and Order Statistics of the new distribution are derived. The
method of maximum likelihood estimation (MLE) is used to estimate the
parameters of the distribution. The performance of the estimators is
assessed through simulation, which shows that the maximum likelihood
method works well in estimating the parameters. The GAPEIEx distribution
was applied to simulated and real data in order to access the
flexibility and adaptability of the distribution, and it happens to
perform better than its submodels.
Season-specific impacts of climate change on canopy-forming seaweed communities.
Authors: Truong Anthony , Edwards Matthew , Long Jeremy
Published: July 2023

Understory assemblages associated with canopy-forming species such as
trees, kelps, and rockweeds should respond strongly to climate stressors
due to strong interaction strengths. Climate change can directly and
indirectly modify these assemblages, particularly during more stressful
seasons and climate scenarios. However, fully understanding the seasonal
impacts of different climate conditions on canopy-reliant assemblages is
difficult due to a continued emphasis on studying single species
responses to a single future climate scenario during a single season. To
examine these more complex interactions, we used mesocosm experiments to
expose intertidal assemblages associated with the canopy-forming golden
rockweed, Silvetia compressa, to elevated temperature and pCO2
conditions reflecting two projected greenhouse emission scenarios [RCP
2.6 (low) & RCP 4.5 (moderate)]. Assemblages were grown in the
presence and absence of Silvetia, and in two seasons. Relative to
ambient conditions, predicted climate scenarios generally suppressed
Silvetia biomass and photosynthetic efficiency. However, these effects
varied seasonally - both future scenarios reduced Silvetia biomass in
summer, but only the moderate scenario did so in winter. These
reductions shifted the assemblage, with more extreme shifts occurring in
summer. Contrarily, future scenarios did not shift assemblages within
Silvetia Absent treatments, suggesting that climate primarily affected
assemblages indirectly through changes in Silvetia. Mesocosm experiments
were coupled with a field Silvetia-removal experiment to simulate the
effects of climate-mediated Silvetia loss on natural assemblages.
Consistent with the mesocosm experiment, Silvetia loss resulted in
season-specific assemblage shifts, with weaker effects observed in
winter. Together, our study supports the hypotheses that
climate-mediated changes to canopy-forming species can indirectly affect
the associated assemblage, and that these effects vary seasonally. Such
seasonality is important to consider as it may provide periods of
recovery when conditions are less stressful, especially if we can reduce
the severity of future climate scenarios.
Matching Study Design to Prescribing Intention: The Prevalent New-User Design for Studying Abuse-Deterrent Formulations of Opioids
Authors: DiPrete Bethany L. , Oh GYeon , Moga Daniela , Dasgupta Nabarun , Slavova Svetla , Slade Emily , Delcher Chris , Pence Brian W. , Ranapurwala Shabbar
Published: July 2023

Purpose: In drug studies, research designs requiring no prior
exposure to certain drug classes may restrict important populations.
Since abuse-deterrent formulations (ADF) of opioids are routinely
prescribed after other opioids, choice of study design, identification
of appropriate comparators, and addressing confounding by “indication”
are important considerations in ADF post-marketing studies.
Methods: In a retrospective cohort study using claims data
(2006-2018) from a North Carolina private insurer [NC claims] and
Merative MarketScan [MarketScan], we identified patients (18-64
years old) initiating ADF or non-ADF extended-release/long-acting
(ER/LA) opioids. We compared patient characteristics and described
opioid treatment history between treatment groups, classifying patients
as traditional (no opioid claims during prior six-month washout period)
or prevalent new users. Results: We identified 8,415 (NC
claims) and 147,978 (MarketScan) ADF, and 10,114 (NC claims) and 232,028
(MarketScan) non-ADF ER/LA opioid initiators. Most had prior opioid
exposure (ranging 64-74%), and key clinical differences included higher
prevalence of recent acute or chronic pain and surgery among patients
initiating ADFs compared to non-ADF ER/LA initiators. Concurrent
immediate-release opioid prescriptions at initiation were more common in
prevalent new users than traditional new users. Conclusions:
Careful consideration of the study design, comparator choice, and
confounding by “indication” is crucial when examining ADF opioid
use-related outcomes.
Improving Targeted Small Molecule Drugs to Overcome Chemotherapy Resistance
Authors: rismanbaf amirhossein
Published: July 2023

Conventional cancer treatments face the challenge of therapeutic
resistance, which causes poor treatment outcomes. The use of combination
therapies can improve treatment results in patients and is one of the
solutions to overcome this challenge. Chemotherapy is one of the
conventional treatments that, due to the non-targeted and lack of
specificity in targeting cancer cells, can cause serious complications
in the short and long-term for patients by damaging healthy cells. Also,
the employment of a wide range of strategies for chemotherapy resistance
by cancer cells, metastasis, and cancer recurrence create serious
problems to achieve the desired results of chemotherapy. Accordingly,
targeted therapies can be used as a combination treatment with
chemotherapy to both cause less damage to healthy cells, which as a
result, they reduce the side effects of chemotherapy, and by targeting
the factors that cause therapeutic challenges, can improve the results
of chemotherapy in patients. Small molecules are one of the main
targeted therapies that can be used for diverse targets in cancer
treatment due to their penetration ability and characteristics. However,
small molecules in cancer treatment are facing obstacles that a better
understanding of cancer biology, as well as the mechanisms and factors
involved in chemotherapy resistance, can lead to the improvement of this
type of major targeted therapy. In this review article, at first, the
challenges that lead to not achieving the desired results in
chemotherapy and how cancer cells can be resistant to chemotherapy are
examined, and at the end, research areas are suggested that more
focusing on them, can lead to the improvement of the results of using
targeted small molecules as an adjunctive treatment for chemotherapy in
the conditions of chemotherapy resistance and metastasis of cancer
cells.
Efficient variable steps BDF2 method for the two dimensional space fractional Cahn-Hilliard model
Authors: Zhao Xuan , Xue Zhongqin
Published: July 2023

An implicit variable-step BDF2 scheme is established for solving the
space fractional Cahn-Hilliard equation derived from a gradient flow in
the negative order Sobolev space H − α , α∈(0 ,1). The
Fourier pseudo-spectral method is applied for the spatial approximation.
The space fractional Cahn-Hilliard model poses significant challenges in
theoretical analysis for variable time-stepping algorithms compared to
the classical model, primarily due to the introduction of the fractional
Laplacian. This issue is settled by developing a general discrete Hölder
inequality involving the discretization of the fractional Laplacian.
Subsequently, the unique solvability and the modified energy dissipation
law are theoretically guaranteed. We further rigorously provided the
convergence of the fully discrete scheme by utilizing the newly proved
discrete Young-type convolution inequality to deal with the nonlinear
term. Numerical examples with various interface widths and mobility are
conducted to show the accuracy and the energy decay for different orders
of the fractional Laplacian. In particular, we demonstrate that the
adaptive time-stepping strategy, compared with the uniform time steps,
captures the multiple time scales evolutions of the solution in
simulations.
Prevalence of proton pump inhibitors drug interactions in community pharmacy: a network analysis approach.
Authors: Lima de Araujo Lorena Maria , Batista Oliveira Júlia Scarlet , Moura Lopes Maria Vivyanne de , Arruda Rafael Silva de , Oliveira Antonio Gouveia , Martins Rand Randall
Published: July 2023

Objective: The aim of this study is to identify the prevalence of drug interaction associated with proton pump inhibitors, associated factors and drugs involved. Methods: Cross-sectional study in 194 customers (> 18 years) of community pharmacies shortly after proton pump inhibitors acquisition (March 2019 to March 2020). Risk factors for drug interaction were assessed via multivariate logistic regression and relevance by network analysis. Results: The prevalence of drug interaction was 16.4% and was related to older age (OR=1.05; 95%CI 1.03 - 1.07) and female sex (OR=2.27; 95%CI 1, 15 - 4.47). The network analysis identified drug interaction involving omeprazole and pantoprazole as the most relevant and related to the prescription of levothyroxine, clopidogrel and cilostazol. Conclusion: The drug interaction among proton pump inhibitors users increase with age and are more common in women, especially those associated with levothyroxine, cilostazol and clopidogrel.
Reestruturação da Farmácia Municipal de União da Vitória-Paraná e Criação De Farmácia Distrital
Authors: Bostelmann Vanessa
Published: July 2023

Ao se considerar que a estrutura física de um serviço afeta diretamente as condições de trabalho dos profissionais e influencia a saúde e práticas exercidas e que maioria das intervenções em saúde acaba por envolver o uso de medicamentos, no sentido de otimizar processos já instituídos, porém extremamente falhos, foi iniciada a reestruturação completa estrutural e gerencial da Assistência Farmacêutica (AF) do município de União da Vitória, Paraná. Deste modo, este relato de experiência tem por objetivo demonstrar a reformulação da Farmácia Básica em questão, a qual, por um longo período encaixou-se no contexto de condições prediais precárias e problemas antigos de ordens gerenciais e organizacionais que acarretavam danos significativos a população bem como abordar sobre a implantação da Farmácia Distrital. Trata-se portanto, de estudo descritivo, do tipo relato de experiência, sobre a reorganização e reestruturação da assistência farmacêutica municipal ocorrida entre 2017 e 2022.  Como resultado das ações, as Farmácias Básicas municipais de União da Vitória passaram a ser consideradas referência e as melhorias foram observadas em vários aspectos principalmente no que diz respeito ao atendimento humanizado. A mudança no panorama foi nítida e hoje são atendidas cerca de quatrocentas pessoas ao dia na central e cento e vinte na distrital que disponibiliza serviços assistenciais nos mesmos moldes da primeira, otimizando o atendimento tendo em vista o redirecionamento de demanda. Como base para tal conclusão, foi evidenciado um número expressivamente maior de pessoas atendidas e satisfeitas com os serviços oferecidos o que parece estar baseado na constatação de um percentual baixíssimo de falta de medicamentos e na reformulação referida. Porém, deve se estar ciente de que nada adianta a melhoria na estrutura física sem o correto gerenciamento do ciclo da assistência farmacêutica, o que permite a oferta adequada dos medicamentos ficando claro que as farmácias básicas devem dispor de infraestrutura e recursos humanos capazes de permitir a integração entre os serviços e o desenvolvimento das ações da AF.
Escassez de medicamentos e a Assistência Farmacêutica na Pandemia da COVID-19: um relato de experiência
Authors: De Oliveira Fatel Karina , Ramos Rodrigues Geuza , Lima Silva Kamila , Simões Oliveira Veronica , Ng Eliza Huang , Fidêncio Alexandra Mariano
Published: July 2023

A pandemia de COVID-19 trouxe grandes desafios aos gestores do Sistema Único de Saúde (SUS), tais como a manutenção de abastecimento de medicamentos utilizados para intubação orotraqueal para pacientes graves, denominado como Kit Intubação (KI). A gestão da assistência farmacêutica (AF) precisou de estratégias inovadoras para a manutenção do abastecimento do KI. Este artigo tem como objetivo descrever a experiência da AF no estado mais populoso do Brasil nas ações relacionadas ao do abastecimento do KI durante a pandemia. Trata-se de um relato de experiência sobre a gestão realizada para abastecimento de 22 medicamentos nos estoques de hospitais públicos de administração direta e indireta, sob gestão estadual e municipal. Dentre as principais ações realizadas pela Coordenadoria de Assistência Farmacêutica da Secretaria de Estado da Saúde de São Paulo temos: gestão do abastecimento, elaboração de relatórios gerenciais; centralização da logística de distribuição de medicamentos; gestão de compras nacionais e internacionais, gestão documental, financeira e de estratégias de comunicação. Conclui-se que as ações gerenciais da AF foram fundamentais para o sucesso do monitoramento e a manutenção de estoques hospitalares no momento de escassez do KI assim como trabalho em equipe e articulação junto aos gestores da AF.
Evaluating the Effect of Electric Vehicle Charging Stations on Power Grids in Sivas Province
Authors: ÇAKIR Mutlu Tarık , ÇAKIR Musa Faruk
Published: July 2023

Due to the damage of fossil fuels to the environment, fossil fuels will finish soon, the interest in electric vehicles has increased. Determining the trend of electric/classic vehicle replacement and additional load on the transformer is vital importance for the investment plans of energy distribution companies. It presents a comprehensive method for including electric vehicle replacements in the investment planning of electric distribution companies. A new model is proposed, used to replace classical vehicles by becoming widespread of electric vehicles. The power density and transformer capacity ratio were examined using the proposed model for scenarios. Electricity consumption, line length, transformer installed power capacity, population, and the number of vehicles data for the last ten years were obtained from ÇEDAŞ and Turkish Statistical Institute. According to scenario comparisons over the 30-year planning, the J value on the grid will exceed the current value between 2029 and 2030, R-value will fall below the current value between 2031 and 2032 in the best case. It is necessary to invest in electricity distribution lines in 2029-2030 and transformer capacities in 2031-2032. The results showed the developed method could be used to determine the line and transformer capacities due to the prevalence of electric vehicles.
DAFO: técnica de proyección estratégica para el trabajo de dirigentes de colectivos de años universitarios
Authors: López Domínguez Abelardo , Guzmán Mirás Yordanka , Diez Fumero Tania , López Domínguez Sandra
Published: July 2023

La toma de decisiones en las acciones estratégicas proyectivas en los entornos universitarios en no pocas ocasiones está caracterizada por la espontaneidad de los directivos, descontextualizadas del medio que circunda a la universidad que influye en ella y el desconocimiento de las esencias internas de ella. Este artículo tiene por objetivo realizar un análisis DAFO como técnica de proyección estratégica en la determinación del problema estratégico general, así como la solución estratégica general para las funciones de los Profesores Principales de Año Académico de las Instituciones de Educación Superior de Cuba. Se parte del origen de la DAFO, su procedimiento metodológico y finalmente se muestra como resultado, un ejemplo concreto de su aplicación, consecuencia de una investigación doctoral de uno de los autores.
Analysis of Stress-Strain State of a Cylinder with Variable Elasticity Moduli Based on Three-Dimensional Equations of Elasticity Theory
Authors: Ismayilova J. J.
Published: July 2023

Introduction. Functionally graded materials are of great use, because heterogeneity of properties enables to control the strength and rigidity of structures. This has caused great interest in the topic in the world scientific literature. The construction of solutions to such problems depends significantly on the type of boundary conditions. In this paper, we consider the equilibrium of a thin-walled circular cylinder whose mechanical properties change along the radius. Homogeneous boundary conditions were set on cylindrical surfaces that had not been considered before, the effect was on the ends. The mathematical formulation of the problem was carried out in the linear theory of elasticity in the framework of axisymmetric deformation. Expressions were constructed for the components of the stress-strain state of the cylinder, in which some coefficients were found from the solution to the resulting system of linear algebraic equations.

Materials and Methods. The material of the cylinder was linearly elastic, the elastic modulus of which depended linearly on the radial coordinate. The basic research method was the asymptotic method, in which half the logarithm of the ratio of the outer and inner radii acted as a small parameter. Iterative processes were used to construct the characteristics of the stress-strain state of the cylinder.

Results. Homogeneous solutions to the boundary value problem were obtained for a linearly elastic functionally gradient hollow thin-walled cylinder. An analysis of these solutions made it possible to reveal the nature of the stress-strain state in the cylinder wall. For this purpose, an asymptotic analysis of the solutions was carried out, relations for displacements and stresses were obtained. It was determined that those solutions corresponded to the boundary layer, while their first terms determined Saint-Venant edge effect similar to the plate theory.

Discussion and Conclusion. The analytical solution to the equilibrium problem of a thin-walled cylinder inhomogeneous in radius constructed by asymptotic expansion can be used for numerical solution to a specific problem. For this, it is required to solve the obtained systems of linear algebraic equations and determine the corresponding coefficients. The resulting asymptotic representations provide analyzing the three-dimensional stress-strain state. The selection of the number of expansion terms makes it possible to calculate displacements and stresses with a given degree of accuracy. This analysis can be useful in assessing the adequacy of applied calculation methods used in engineering practice.
Aspects of Thermal Protection of Machine-Building and Power Equipment: Application of Oxidation-Resistant Combined Nickel-Based Coatings
Authors: Varavka V. N. , Kudryakov O. V. , Grishchenko V. I.
Published: July 2023

Introduction. In the areas of power engineering where the thermal energy of superheated steam is used, an important aspect of providing the reliability and safety of equipment is the heat resistance of the materials employed. In the manufacture of induction superheaters, the optimal material for the steam pipe (coil) is copper. However, its ultimate resistance to oxidation does not exceed 400 °C, which significantly limits the efficiency of steam generators. Therefore, the objective of the work was to study the kinetics of oxidation of the combined galvanic coating of the Mo-Ni-Cr system applied to copper tubular samples and intended for thermal protection of steam generator coils.

Materials and Methods. A combined electroplating of the Mo-Ni-Cr system with a total thickness of 12–35 μm was formed on the experimental copper tubular samples. A Mo sublayer with a thickness of about 1.5 μm on the surface of the copper tube was formed to prevent the diffusion of Cu into the Ni coating. A 1.5 μm thick chromium layer on the coating surface acted as an indicator of the oxidation process. A comparative analysis of the oxidation processes of the copper surface and the combined coating of the Mo-Ni-Cr system on a copper substrate was carried out using the methods of optical and electron microscopy, energy dispersive analysis, and precision determination of the growth parameters of oxide films.

Results. The intervals of thermal stability of the copper substrate and nickel coating were experimentally determined. The obtained experimental dependences characterized the parabolic law of copper oxidation with the formation of a single-phase diffusion zone of CuO at temperatures above 350 °C, and nickel at temperatures above 750 °C, when the transition of NiO monoxide into oxide Ni2O3 began. The growth of oxide films according to quadratic laws provided a rapid increase in the thickness of the films, the accumulation of stresses in them, cracking, and chipping.

Discussion and Conclusion. It is shown that the Mo-Ni-Cr electroplating is resistant to heating during long-term operation up to temperatures of 750–800 °C. The functional roles of Mo and Cr in the coating architecture were described. The work focused on the applied aspect of using the coating under study to increase the thermal stability of the steam pipelines of industrial induction superheaters with low and medium power.
Simulation of Vertical Movements of Seawater in Stratified Reservoirs
Authors: Kudinov N. V. , Filina A. A. , Nikitina A. V. , Bondarenko D. V. , Razveeva I. F.
Published: July 2023

Introduction. In the field of computational mathematics, there are many ways to approximate the model of fluid mechanics. Methods and estimates of approximation quality criteria, such as stability and convergence, are developed, while a combination of approaches to constructing economical difference schemes, such as splitting by physical processes, regularization by B. N. Chetverushkin, a linear combination of the Upwind and Standard Leapfrog difference schemes in aggregate has not been implemented and evaluated before. The authors were faced with the task of approximating each part of the hydrodynamic model split by physical processes with the most adequate scheme and further investigating the correctness of this approach.

Materials and Methods. The mathematical model of hydrophysical processes is closed by the empirical equation of the state of salt water. Significant properties were selected, a mathematical model was built. Difference operators approximated differential operators. An algorithm for layer-by-layer modeling of transients was constructed. The algorithm has been implemented in the form of the program, which mainly contains elementwise (massively-parallel) operations.

Results. Mathematical models of hydrodynamic processes in reservoirs were obtained, taking into account three equations of motion in the presence of a density gradient of the aqueous medium when hydrostatic approximation was abandoned. A new method of calculating the pressure field using B. N. Chetverushkin’s regularizers in the continuity equation was tested. A software module for numerical simulation of hydrophysical processes of water movement with different salinity and density was developed. This is open-source software that provides not only the redefinition of empirical dependences (as algebraic functions), but also the connection of external simulating modules to display dependences algorithmically.

Discussion and Conclusion. The developed model of hydrophysics, taking into account the properties of salt water and the dynamic relationship of the mechanical movement of water with salinity, can be used to study the formation of a nonequilibrium distribution of parameters and identify the most stable parameters of the aquatic environment. The model explains the downward movement of oxygen. That will help in the future to estimate the values of the parameters of the aquatic environment, which are difficult to measure directly. It can be used in the procedure of parametric identification of hard-to-measure parameters of the aquatic environment.
Clinical Variations Between Different Forms of Achalasia
Authors: Sánchez Terán Alfonso Iván , Naranjo Pardo Catalina , Varela Barraza Omar , Prado Salcedo Tatiana , Macías Grajeda Michelle
Published: July 2023

Background: Esophageal achalasia is a motility disorder characterized by a lack of esophageal peristalsis and failure of the lower esophageal sphincter (LES) to relax. Patients typically present dysphagia for both solids and liquids, regurgitation, retrosternal chest pain, cough, aspiration, weight loss and heartburn, which affect their quality of life. Objective: To determine whether the High-resolution manometry (HRM) achalasia subtypes could be differentiated based on symptoms or radiographic findings. Methods: A cross-sectional study design was used, and data collected from 60 patients between 18 and 65 years and a diagnosis of achalasia using HRM over a period of ten years. The symptom assessment was done in a clinical interview using three international questionnaires for esophageal symptoms. Results: The mean symptom duration for the 3 groups was 25.03 ± 24.88 months, type I 25 ± 22.76 months and type II 24.98 ± 27.32 months, type III had a median of 27 (18-36) months. The mean esophageal diameter of patients with achalasia was 4.87 ± 1.48 cm. Type I had the greatest dilation (5.37 ± 1.7 cm) when compared to type II (4.46 ± 1.03 cm) and to type III 2.75 (2-3.5) cm. The mean esophageal length of all achalasia patients was different among the groups; type I 24.19 ± 2.96 cm and type II 22.96 ± 2.23 cm, type III had a median of 20.63 (20.13-18.13) cm. Conclusions: Despite the difference in degree of dilation between the subtypes, symptom duration does not appear to be correlated to the pattern of the achalasia.
PREDIKSI PENDERITA DIABETES MENGGUNAKAN METODE NAIVE BAYES
Authors: Rahayu Citra Agustina
Published: July 2023

Prediksi adalah upaya memperkirakan sesuatu yang akan terjadi di masa depan dengan menggunakan berbagai informasi yang relevan pada waktu sebelumnya dengan menggunakan metode ilmiah. Data mining adalah kumpulan berbagai data atau informasi yang memiliki berbagai fungsi dan sangat bermanfaat di masa mendatang. Pemanfaatan data mining juga tidak hanya untuk teknologi saja melainkan bisa untuk Bidang Kesehatan salah satunya memprediksi penyakit diabetes dengan menggunakan metode Naive Bayes yaitu algoritma yang meminimalkan Kesehatan dari semua metode yang lain. Diabetes mellitus juga dikenal sebagai sekelompok masalah metabolism yang ditandai dengan tingginya kadar gula darah yang berkepanjangan. Diabetes dapat menyebabkan masalah kesehatan yang serius termasuk penyakit kardiovaskular. Penelitian ini bertujuan untuk memprediksi dan mengukur tingkat akurasi penyakit Diabetes. Pengumpulan data yang dilakukan di RSUD dr.soekardjo dengan menghasilkan 502 data pada rekam medis July 2019 – Desember 2022. Pengolahan Naive Bayes menghasilkan prediksi dengan 5 kali pengujian yaitu sebesar 57,38%, 70,27%, 78,26%, 85,71% dan 88,93%.  Akurasi tertinggi sebesar 95.92% artinya rule yang dihasilkan mendekati 100%.
RANCANG BANGUN ALAT MONITORING SUHU MENGGUNAKAN SENSOR DS18B20 DAN PENGADUK OTOMATIS PADA PROSES FERMENTASI KAKAO
Authors: Maheswara Maulana Fahar , Purwiyanti Sri , Sumadi Sumadi , Nasrullah Emir
Published: July 2023

Kakao (Theobroma cacao L.) merupakan salah satu komoditas perkebunan yang penting bagi perekonomian Indonesia. Fermentasi kakao merupakan proses pasca panen dari komoditas kakao, proses fermentasi membutuhkan waktu antara 3 sampai dengan 6 hari. Fermentasi kakao pasca panen akan menghasilkan cita rasa dan aroma yang lebih optimal pada olahan kakao seperti coklat batang dan juga olahan kakao lainnya. Pada proses fermentasi tersebut suhu fermentasi kakao akan bervariasi dimana perubahan suhu ini disebabkan  oleh mikroorganisme yang ada pada kakao. Pemantauan suhu selama proses fermentasi sangat penting untuk menghasilkan kakao bermutu tinggi. Pengadukan biji kakao juga penting untuk memastikan fermentasi berlangsung secara merata. Pada penelitian ini dibuat sebuah alat yang dapat mengukur dan mencatat serta juga melakukan  pengadukkan secara otomatis pada proses fermentasi kakao. Pada penelitian ini diggunakan sensor DS18B20 sebagai pengukur suhu, MicroSD dan thingspeak sebagai pencatat data dan juga relay sebagai kontrol otomatis pengadukkan fermentasi kakao. Setelah dilakukan penelitian diketahui bahwa alat ini berhasil melakukan pengadukan dan pencatatan secara otomatis dan juga dapat memberikan notifikasi telegram pada saat terjadi pengadukkan. Dari hasil pemantauan fermentasi yang dilakukan selama 5 hari diketahui bahwa suhu selama proses fermentasi antara 29,2°C sampai dengan 42,8°C dengan error pembacaan sensor sebesar 0.4% .
IMPLEMENTASI RULE BASED SYSTEM UNTUK SISTEM JADWAL PAKAN IKAN KOMET OTOMATIS BERBASIS ANDROID
Authors: Ardiansyah Muhammad
Published: July 2023

Abstrak. Implementasi Rule System Untuk sistem Alat Pakan Ikan Komet Otomatis Berbasis Android. Penelitian ini bertujuan untuk membantu pedagang ikan komet dalam memberikan pakan pada aquarium. Dalam memberikan pakan ikan komet masih secara manual dan belum terjadwal secara pasti sehingga tidak efisien untuk memberikan pakan kepada ikan tersebut. Metode yang digunakan dalam penelitian ini adalah Rule Based System yang digunakan sebagai penjadwalan waktu pakan ikan komet otomatis. Hasil dari perancangan sistem alat pakan ikan otomatis berbasis android jadwal pakan ikan sebaiknya diberikan pada pukul 07.00, pukul 12.00, pukul 17.00 dan pukul 21.00.Kata Kunci: Alat Pakan Ikan Komet Otomatis Berbasis Android,Ikan Komet, RTC (Real Time Clock).
ANALISIS APLIKASI TIKTOK BERDASARKAN PRINSIP DAN PARADIGMA INTERAKSI MANUSIA DAN KOMPUTER MENGGUNAKAN EVALUASI HEURISTIC
Authors: Rosiana Puput Silva , Nurhidayat Ananada Rizky , Mohsa Alpin Apriliansyah , Ridha Azhari Ali
Published: July 2023

Aplikasi TikTok telah menjadi fenomena global dengan popularitas yang pesat. Namun, dalam rangka meningkatkan pengalaman pengguna, penting untuk menganalisis aplikasi ini dari perspektif interaksi manusia dan komputer. Tujuan dari penelitian ini adalah untuk menganalisis aplikasi TikTok menggunakan evaluasi heuristic yang didasarkan pada prinsip dan paradigma interaksi manusia dan komputer. Metode penelitian yang digunakan adalah evaluasi heuristic, yang melibatkan penilaian berdasarkan prinsip-prinsip interaksi manusia dan komputer yang telah ditetapkan sebelumnya. Penilaian dilakukan dengan mengamati dan menguji interaksi antara pengguna dan aplikasi TikTok dalam berbagai konteks penggunaan. Data yang terkumpul selama evaluasi dianalisis secara kualitatif untuk mengidentifikasi kekuatan dan kelemahan dalam interaksi antarmuka pengguna. Hasil analisis menunjukkan bahwa aplikasi TikTok memiliki beberapa kekuatan dalam hal interaksi manusia dan komputer. Beberapa kekuatan tersebut meliputi antarmuka yang intuitif dan mudah digunakan, responsivitas yang cepat, dan penyajian konten yang menarik. Namun, juga terdapat beberapa kelemahan yang teridentifikasi, seperti navigasi yang kurang jelas, kurangnya kontrol pengguna terhadap algoritma penentuan konten, dan kurangnya fitur privasi yang memadai. Berdasarkan temuan tersebut, rekomendasi perbaikan diajukan untuk meningkatkan interaksi pengguna dengan aplikasi TikTok. Rekomendasi tersebut termasuk penyempurnaan navigasi, peningkatan transparansi algoritma, dan penambahan fitur privasi yang lebih kuat. Diharapkan bahwa hasil penelitian ini dapat memberikan kontribusi dalam pengembangan aplikasi TikTok dan membantu para pengembang dalam merancang antarmuka yang lebih baik.
VERIFIKASI DOKUMEN TRANSKRIP NILAI SEMESTER MENGGUNAKAN METODA OPTICAL CHARACTER RECOGNITION
Authors: Hatala Zulkarnaen
Published: July 2023

At the Ambon State Polytechnic, students' semester grade reports are still manually typed. This causes frequent typo errors which can result in the invalidity of the document, let alone incorrect grades, student identification numbers and many other label values. Here a java application has been implemented to detect these errors. This application is primarily intended for officials of the Head of Study Program, Head of the Department before signing and validating the report. Officials who legalize it will be greatly assisted because tedious validation work can be replaced by computers. The validation process is carried out by utilizing the optical character recognition technique from the open source library Tesseract-OCR. From the experimental results the verification process can be improved by using OCR  specific on specific regions of interest (ROI) after using template matching method from OpenCV. The consideration of the Levehnstein distance in the comparison of label values against the reference database also improves the success rate of the algorithm. The database used has been tested for about 800 grade report documents, with successful verification result above 90%.
PROTOTIPE ROBOT PEMBERSIH LANTAI BERBASIS MIKROKONTROLER
Authors: Tamam Muhammad Taufiq
Published: July 2023

The development of automation has penetrated into all areas of life, including household appliances. One of them is robot technology for cleaning floors. With relatively small dimensions, this floor cleaning robot can reach under a table or bed. This floor cleaning robot is equipped with a microcontroller, suction pump and ultrasonic sensor to detect obstacles when scanning the floor surface. The microcontroller will process the ultrasonic sensor readings. If an obstacle is detected, the robot will avoid it by turning right or left. The suction pump is made of a 12 V DC motor with a suction power of 0.19 W for dust and 1.09 W for paper scraps. Based on the test results, this robot has a suction speed of 2.14 m/s and a suction capacity of 5.44x10-4 m3/s. With this floor cleaning robot, the job becomes lighter and easier.
A fractional numerical study on a plant disease model with replanting and preventive treatment
Authors: Alqahtani Z. , Hagag A.
Published: July 2023

Food security has become a significant issue due to the growing human population. In this case, a significant role is played by agriculture. The essential foods are obtained mainly from plants. Plant diseases can, however, decrease both food production and its quality. Therefore, it is substantial to comprehend the dynamics of plant diseases as they can provide insightful information about the dispersal of plant diseases. In order to investigate the dynamics of plant disease and analyze the effects of strategies of disease control, a mathematical model can be applied. We show that this model provides the non-negative solutions that population dynamics requires. The model was investigated by using the Atangana-Baleanu in Caputo sense (ABC) operator which is symmetrical to the Caputo-Fabrizio (CF) operator with a different function. Whereas the ABC operator uses the generalized Mittag-Leffler function while the CF operator employs the exponential kernel. For the proposed model, we have displayed the local and global stability of a nonendemic and an endemic equilibrium, existence and uniqueness theorems. By applying the fractional Adams-Bashforth-Moulton method, we have implemented numerical solutions to illustrate the theoretical analysis.
ANALISIS KESALAHAN SISWA SD DALAM MENYELESAIKAN SOAL CERITA MATERI BANGUN DATAR BERDASARKAN PROSEDUR NEWMAN
Authors: Safitri Ingka , Witono A. Hari , Nur Kholifatur Rosyidah Awal
Published: July 2023

Tujuan pembelajaran matematika di SD adalah memahami konsep matematika, mendeskripsikan hubungan antara konsep dengan aplikasi konsep secara luwes, akurat, dan efisien saat memecahkan masalah. Namun, tujuan tersebut belum bisa tercapai hal ini teridentifikasi dari banyaknya siswa yang salah dalam penyelesaian soal cerita matematika. Tujuan penelitian ini adalah untuk mendeskripsikan kesalahan yang dilakukan siswa dalam menyelesaikan soal cerita bangun datar, khususnya pada materi keliling dan luas pada persegi, persegi panjang dan segitiga berdasarkan prosedur Newman. Penelitian ini merupakan penelitian kualitatif deskriptif yang dilakukan di SDN 52 Cakranegara pada tahun pelajaran 2022/2023. Teknik pengumpulan data yaitu tes, wawancara, dan dokumentasi. Analisis seluruh data dilakukan dengan langkah: reduksi data, penyajian data, verifikasi, triangulasi dan kesimpulan. Berdasarkan hasil analisis diperoleh (1) Subjek kategori baik cenderung melakukan kesalahan process skill dan encoding, (2) Subjek kategori sedang cenderung melakukan kesalahan transformation dan process skill, (3) Subjek kategori kurang cenderung melakukan kesalahan comprehension, transformation, dan process skill. Dari hasil penelitian dapat disimpulkan bahwa kesalahan process skill menjadi kecenderungan semua kategori. Kesalahan ini diindikasikan dengan subjek yang tidak dapat melakukan operasi perhitungan dan tidak mengetahui langkah penyelesaian soal dengan benar.
Back to the Present of Automated Mobility
Authors: Solbu Gisle , Skjølsvold Tomas Moe , Ryghaug Marianne
Published: July 2023

This article focuses on how car drivers domesticate technologies of automation and the way this might inform our understanding of potential shifts to a more automated mobility system. The current literature on automated mobility has mainly addressed drivers’ roles in terms of their attitudes towards—and acceptance of—an anticipated shift to high-level driving automation. In this article, however, we take a step back from expectations around automated mobility to explore the domestication of driving assistance technologies and systems already in use.  The analysis is built on qualitative interviews with drivers of private cars in Norway. Based on our findings, we develop a typology of user-technology characterizations highlighting three themes of the drivers’ use (comfort, safety, and novelty) as well as two modes of engagements (modulation and non-use). Our analysis suggests that automation is likely to be an incremental and gradual process and that its eventual application depends on the specificities of the practices that it seeks to disrupt. Moreover, we argue that the governance of automated mobility needs to be attentive to the dynamic and unpredictable roles technology will have in processes of socio-technical change. In this context, we highlight the key roles of users in shaping processes of appropriation of both new technologies and broader innovations and argue that knowledge about technology domestication provides important insights to changes towards automation in our current mobility systems.
THE INFLUENCE OF CAPITAL INVESTMENT VOLUMES ON GROSS REGIONAL PRODUCT GROWTH IN THE REGIONS OF UKRAINE
Authors: Odintsov M.M. , Odintsov O.M. , Momot S.V.
Published: July 2023

The article examines the influence of the dynamics of capital investment growth on the growth of gross regional product in the regions of Ukraine. To do this, an analysis of the relationship between capital investment and gross regional product (GRP) using a regression function. Based on regression analysis, the values of investment multipliers and accelerators were calculated, which showed a high closeness of the interdependence between the volume of gross regional product and fixed capital investment. The return on capital investment in the economy of the regions with the growth of gross regional product is also determined, the reverse effect of investment growth together with the growth of gross regional product. In the constructed models of multipliers and accelerators of regions rather considerable sums of the remains which have led to necessity of introduction in construction of models in addition of such important factor of production as work are revealed. Construction of a two-factor production function with factors of capital investment and labor (expressed in wages) made it possible to determine the productivity of production resources of regions and indicators of elasticity of the influence of these factors on the formation of gross regional product of regions. The study revealed a close relationship between capital investment and gross regional product, as evidenced by the values of the coefficients of determination and correlation. This makes it possible to determine the required level of investment in fixed capital at a given volume of gross regional product and is of practical interest in forecasting economic growth in the regions of the country.
IMPLEMENTATION OF MARKETING INSTRUMENTS INTO ANTI-CRISIS PROGRAMS OF NATIONAL TOURIST MARKET PLAYERS
Authors: Krupenna I.A. , Fortuna D.I.
Published: July 2023

The article gives grounding to importance of implementation of marketing instruments into anti-crisis programs of main players of tourist operators segment of national tourist market. It points out that anti-crisis marketing is aimed at giving assistance to tourist market players to identify the perspectives of the market, elaborate strategic trends and choose tactical instruments of exit from the crisis situation with minimal losses.

It regards the consequences of the current crisis for tourist sector: economic consequences, consequences for means of living and goals of sustainable development, consequences for environment and climate, cultural consequences.

It is also pointed out that the current crisis forms unprecedented possibilities of interaction transformation between tourism and nature, climate and economics. It is determined that certain innovational startup-projects can suggest solution of saving the tourist domain from consequence of Corona virus, form added value, have tested prototype and business-plan as well as the potential for use in other countries.

It accentuates attention on marketing activities connected with renovation of internal tourism, involvement of internal tourists, on the necessity to study trends, potential demand, prepare new products, establish communications with tourists with orientation to national tourist destinations. At the same time, the article describes problems that accompany tourist operators’ work with national accommodation means and absence of state program of internal tourism development with strict performance control.

The article also analyses activity of the biggest tourist operators of Ukraine in conditions of current crisis and their interaction with tourist agencies and tourists: Anex tour, Join UP!, TUI Ukraine. It makes the conclusion that in spite of difficult situation with pandemic, quarantine restrictions and lockdowns, recurrent waves of COVID-19, restrictions of entry and stay in many popular tourist destinations, the majority of tourist operators did not terminate marketing activity, adapted to the realia of the pandemic. It is pointed out that Ukrainian tourist market players must take into account a number of factors that will determine customer behaviour (choosing shorter terms of rest, preference to individual travel (auto-tourism), individual transfers, individual accommodation, priority of choosing wellness, marine and rural tourism) and select adequate marketing anti-crisis instruments. The article draws attention to popular leisure concept of bleisure (mix of rest and work) as a response to active development of remote work topic and increasing number of “digital travellers”. Such marketing approach is caused by the necessity not only to continue the tourist season but also to develop cultural and historic tourism, shopping tourism, wellness tourism.
IMPLEMENTATION OF THE ENERGY TRANSITION IN UKRAINE AND AT THE WORLD
Authors: Osadchenko I.O.
Published: July 2023

The article is devoted to assessing the progress of mankind on the way to a "green" energy transition. Globally, the cost of energy from renewable sources reaches the level of newly built thermal power plants. The built-in multifactor regression model shows that increasing the share of renewables, reducing emissions and reducing fuel imports are closely related to increasing the return on energy to gross domestic product. A study of the link between GDP growth and greenhouse gas emissions in Europe and the world shows that while the relationship between emissions and economic well-being has been successfully overcome in developed countries, global low-carbon economic growth has not yet been achieved. Taking into account fiscal incentives, new electric cars are already economically feasible in developed countries and it is expected that from 2023 they will be in equal competition with cars with internal combustion engines without incentives. Ukraine currently lags behind the global level in the level of implementation of renewable energy, energy intensity and electric vehicles.
Análisis estadístico de los efectos de la cuarentena por covid 19 en la calidad del aire de Bogotá y 20 ciudades del mundo (enero a julio de 2020)
Authors: Rincón Rueda Gustavo Andrés , Murad Pedraza Jose Alejandro
Published: July 2023

Objetivo: comparar el comportamiento de la contaminación del aire durante la cuarentena en la ciudad de Bogotá, con respecto a otras ciudades del mundo en aspectos como la población, área, entre otros, mediante un análisis estadístico de los datos de concentración de los contaminantes PM10, PM2.5 y NO2, para el periodo de enero a julio del 2020.Materiales y métodos: se seleccionaron 20 ciudades según la matriz para el análisis del estudio. Con la técnica BOOTSTRAPPING se realizó una matriz de correlación e histogramas para cada uno de los contaminantes por fase. Para la aplicación del PCA se realizó el análisis con el software MATLAB, respecto a los promedios por fases y magnitudes de cambio. Con el software SPSS se realizó la normalización de los datos para el tratamiento de las variables de interés. Por medio de la modelación ARIMA y ETS, se analizaron los datos de forma longitudinal, el pronóstico de concentraciones con y sin cuarentena, incluyendo la comparación entre ciudades. Resultados: en la fase reactivación Bogotá presentó un aumento significativo en sus niveles de contaminación, especialmente en PM10. En las diferencias entre las fases antes y reactivación, obtuvo una menor magnitud en el caso de PM2.5, mientras que para el NO2 fue más marcada. Conclusiones: en la cuarentena Bogotá experimentó una disminución significativa en la concentración de PM10 y NO2. Esto no fue el caso para la concentración de PM2.5 a causa de distintos eventos temporales (incendios y transporte de material particulado)