bluuebunny/crossref_metadata_2025 huggingface dataset:
Cloning and functional characterization of the OBSCURAVENOSA gene in tomato (Solanum lycopersicum L.)
Authors:   , Moreira Juliene dos Reis
Published: May 2022

Heterobaric and homobaric leaves are found in many plant families and have a remarkable distribution in nature. What differentiates these two types of leaves is the presence or absence of bundle sheath extensions (BSEs), a structural trait which produces different physiological responses. Leaves with BSEs (heterobaric) have greater hydraulic integration and greater photosynthetic performance, on the other hand, leaves without BSEs (homobaric) have uniform photosynthesis along the blade and probably an improved mechanism to control water loss under stress conditions. Tomatoes currently cultivated were selected after long years of crop breeding. Originally, tomato is a heterobaric crop, however, most field cultivars have a spontaneous recessive mutation known as obscuravenosa (obv) and, as a consequence, have lost the BSEs. For several years, this mutation was unconsciously selected in conjunction with other traits of agronomic interest. This suggests that the variation between homobaric and heterobaric characters has agronomic value in tomato. The first step to better understand the impacts of BSE at the plant level and to be able to manipulate it within the tomato crop and in other crops is knowing the genes involved in its formation. For this, we use tomato as a model to elucidate the molecular bases that control the development of BSEs. Using publicly available resources combined with in silico analysis, we identified a strong candidate gene for the obv mutation. Solyc05g054030 has a SNP (A→G) in the third exon, which leads to the exchange of a histidine residue for arginine at position 135 of the protein. The gene encodes a zinc finger transcription factor C2H2 type. We have shown through predictions that the OBV protein has three classic zinc finger domains, which allow interaction with DNA. In the obv mutant, the exchange of histidine for arginine caused the loss of a zinc finger motif, which may have led to the interruption of the protein functionality. We complemented the obv mutant with the functional OBV allele recovering the clear vein phenotype . OBV further regulates the leaf insertion angle, leaf serration, vein density and fruit shape. OBV appears to coordinate the development of BSEs through an auxin-mediated mechanism, specifically by changes in some members involved in auxin signaling (ARFs and Aux/IAAs). We have identified a link between OBV and AUXIN RESPONSE FACTOR 4 (ARF4). The findings reported here will give support for identification of other components linked to the molecular pathway that directs the formation of BSEs in leaves. Keywords: Bundle Sheath Extension. Heterobaric leaf. Molecular cloning. Auxin.
Ensino de matemática mediado pelas tecnologias digitais: uma experiência no 8º ano do ensino fundamental com o Teorema de Tales
Authors:   , Nogueira Mônica Aparecida
Published: May 2022

A Pandemia da Covid-19 acelerou a quebra de paradigmas nas mais diversas atividades humanas incluindo, notavelmente, o âmbito da educação escolar. Até então, muito se falava da inserção das Tecnologias Digitais de Informação e Comunicação (TDICs) no processo de escolarização nos tempos atuais, porém, observávamos que na prática escolar havia pouca utilização destes recursos no ensino da Matemática. Neste cenário de crise sanitária, tais tecnologias assumiram um papel relevante na escola básica. Além disso, as metodologias ativas são apresentadas como abordagens pedagógicas que oportunizam uma aprendizagem significativa por parte dos estudantes. Esta pesquisa, de caráter exploratório, tem como principal objetivo estudar as contribuições de um ambiente digital - WebQuest - para o ensino de conceitos geométricos - Teorema de Tales - no oitavo ano do Ensino Fundamental. Os dados foram coletados a partir de questionários e documentos elaborados pelos estudantes e foram tratados numa perspectiva qualitativa. Os resultados sinalizam para um aumento do interesse pela matemática nos participantes da pesquisa. Os alunos aprenderam com a WebQuest e a atitude diante das tarefas a realizar ficou mais comprometida. Perceberam que as tecnologias digitais podem ser aliadas na aprendizagem matemática. Além disso, ficou manifesta a desigualdade de acesso dos estudantes às tecnologias de comunicação e informação. Esta pesquisa disponibiliza um produto educacional para os professores da escola básica. Palavras-chave: Matemática Escolar. Ensino de Geometria. Anos Finais. WebQuest.
Effect of COVID-19 coronavirus infection on the course of rheumatoid arthritis
Authors: Sorotskaya V. N. , Plakhova A. O. , Halmuradova B. B. , Vaisman D. S. , Balabanova R. M.
Published: May 2022

To date, there are numerous studies on the effect of COVID-19 on the course of autoimmune rheumatic diseases and the value of vaccination in preventing this dangerous viral infection.

Objective: to assess the effect of coronavirus infection on the course of rheumatoid arthritis (RA), the severity of infection, the effect of current baseline therapy on infection outcomes, and the role of vaccination against COVID-19.

Patients and methods. 134 patients with a reliable diagnosis of RA were interviewed and their outpatient records analysed during the pandemic period from January 2020 to July 2021.

Results. Most of the patients were in the older age group (62.7 years on average), had an average disease duration of 13 years, low to moderate RA activity, comorbidities including arterial hypertension, excess body weight, type 2 diabetes mellitus, etc. All patients received synthetic basic anti-inflammatory drugs (BАID) and glucocorticoids (GC). Thirtyseven (27.6%) patients were vaccinated with the Sputnik V vaccine. Their adverse events were represented by soreness at the injection site (n=6) and transient flu-like syndrome (n=6). Worsening of joint syndrome was reported by 1 patient. COVID-19 was suffered by 43 patients, none of whom were vaccinated. 7 patients were hospitalized, 3 patients died (all had severe comorbidities). In the post-infection period, weakness (64%), memory impairment (48.7%), reduced ability to work (38.5%) persisted for a long time (42 days on average), which was due to the long withdrawal of BАID.

Conclusion. No exacerbations of the disease were noted in those vaccinated with Sputnik V. COVID-19 was detected in 43 (32.1%) patients, 7 of whom required hospitalization and 3 died. Exacerbation of RA in the post-infection period was associated with prolonged withdrawal of BАID.
On the issue of post COVID-19 condition in patients with rheumatic diseases
Authors: Beketova M. F. , Babak V. V. , Suprun M. D. , Beketova T. V. , Georginova O. A.
Published: May 2022

Actual problems of rheumatology include the possibility of developing a wide range of long-term consequences of COVID-19, so-called post-COVID syndrome (PCS). The results of our own research are presented, during which among 45 patients over 18 years with rheumatic diseases (RD) PCS was detected in 20% cases: 6 of them had ANCAassociated vasculitis (AAV) and one each for rheumatoid arthritis, juvenile arthritis and osteoarthritis. In AAV cases PCS was more severe and varied than in other RD: lung lesions according to computed tomography (up to the damage 75% of the lung parenchyma), skin an d nervous (Guillain–Barré syndrome) lesions, myalgias, arthralgias were present. In most patients PCS ended in recovery, sudden death occurred only in the patient with AAV. The frequency of RD’s relapses in patients with PCS was 9%. Relapses were not noted in AAV, against the background of anti-B cell therapy with rituximab. Our own results and literature data indicate that patients with RD after COVID-19 need careful continuous monitoring to detect long-term complications of coronavirus infection and early diagnosis of relapses of the underlying disease.
Primary conservative treatment PCL rupture in athletes
Authors: Zaripov A. R. , Afanasiev A. P. , Magnitskaya N. E. , Ryazantsev M. S. , Logvinov A. N. , Ilyin D. O. , Pilipson Zh. Yu. , Frolov A. V. , Maysigov M. N. , Korolev A. V. , Lazko F. L. , Akhpashev A. A.
Published: May 2022

The purpose of this study: to evaluate the results of conservative treatment of isolated grade II and III PCL rupture in athletes.

Materials and methods. The study included 36 patients who were athletes at a professional level, with isolated PCL rupture, and have been treated non-operative in the period from 2012 to 2020. The non-operative protocol of isolated lesions of the PCL involve, bracing with posterior leg support, rehabilitation program determined by the symptoms and physical signs.

Results. After 2 years from injury, the average score on the Tegner scale was 9 (5–10) (p=0.42). 32 (89%) patients returned to the previous level of sports activity, the average score on the Tegner scale was 9 (7–10). The mean time to return to sports-specific training was 10.6 (4–27) weeks, and the mean time to return to full competitive sport was 16.4 (10–40) weeks. Conclusion. The non-operative management of isolated, Hughston grade II and III PCL injuries gives excellent functional outcomes with a high proportion returning to the same level of sport.
Persistent effect of tocilizumab in refractory Takayasu’s arteritis (clinical observation)
Authors: Koilubaeva G. M. , Sarybaev A. Sh. , Bolotbekova A. M. , Dubinina T. V. , Nasonov E. L. , Dzhuzenova F. S. , Chukubaev M. A. , Turdukulov Z. E. , Dzhailobaeva K. A.
Published: May 2022

Study of the interleukin 6 (IL-6) role in chronic autoimmune inflammation has led to the development of innovative treatments for various autoimmune inflammatory rheumatic diseases, including Takayasu’s arteritis (TAK). Given the important role of IL-6 in the pathogenesis of TAK and its association with high clinical and laboratory activity of the disease, tocilizumab (TCZ) is recommended as a second-line drug if both glucocorticoids and basic antiinflammatory drugs are inefficient, and previous therapy with tumor necrosis factor-α (alpha) inhibitors. The article presents our own observation of the successful use of TCZ in a patient with refractory TAK.
Association of Candida Species with Novel SARS-CoV-2 and Biomarkers for Fungal Premalignant Oral Lesions
Authors: Aslam Sidra , Sarah Ghafoor
Published: May 2022

Oral fungal infections can be caused by certain species of fungi among which candida albicans is the most implicated. Oral candidiasis is correlated with multiple conditions, such as coronavirus disease-2019, oral leukoplakia and oral erythroplakia. Tenascin is a glycoprotein and is present at the site of tissue injury and chronic inflammation, and tends to be over-expressed in cases of malignancy. Matrix metalloproteinase-9 belongs to a family of zinc-dependent endopeptidases and is involved in the degradation of extracellular matrix, leading to tissue invasion and metastasis. The current narrative review was planned to shed light on the fungal co-infections of coronavirus disease-2019 and molecular mechanisms of matrix metalloproteinase-9 and tenascin involved in the pathogenesis of fungus-associated oral leukoplakia and oral erythroplakia.
Key Words: Oral, fungal, COVID-19, Tenascin, MMP-9.
Taswira ya Jamii ya Kisasa kwa Mujibu wa Riwaya Teule za Kisasa za Mwandishi K.W. Wamitila
Authors: Mutua Janice
Published: May 2022

Lengo: Makala hii inakusudia kuangazia taswira kamili ya jamii ya kisasa kama ilivyodhihirika katika riwaya mpya teule za Musaleo! na Mwandishi, Msomaji na Mchapishaji zilizoandikwa na K.W. Wamitila. Mwandishi amefanikiwa kuieleza jamii ya kisasa kupitia kwa usimulizi wenye simulizi nyingi fupi fupi ambayo ni kipengee kimojawapo cha mbinu ya utunzi ya kimajaribio.

Mbinu ya utafiti: Mtafiti aliafikia lengo la utafiti kwa kutumia mbinu ya uchanganuzi wa yaliyomo mkabala wa ufasili. Mtafiti ameangazia maandiko yenye uhusiano na jinsi riwaya mpya ilivyoichorea hadhira taswira ya jamii husika. Kipengee cha kimajaribio kilichotumika ni matumizi ya simulizi fupi fupi zilizomo katika simulizi kuu. Data ya utafiti ilikusanywa maktabani kutoka katika uchambuzi wa maudhui katika riwaya za Musaleo! (ML) na Mwandishi, Msomaji na Mchapishaji (MMM). Nadharia ya Usasaleo kama ilivyoasisiwa na Jean Baudrillard iliuongoza utafiti katika ukusanyaji na uchanganuzi wa data.

Matokeo: Utafiti umebaini kwamba ukosefu wa utaratibu katika utekelezaji wa shughuli mbali mbali uandishi ukiwemo, waweza kuonekana usiofaa lakini hiyo ndiyo taswira kamili ya maisha katika jamii ya kisasa; hayana utaratibu mahususi. Hali ya mparaganyiko imechukua nafasi kubwa ya maisha ya kisasa. Makala imebainisha kuwa jamii inakabiliana na changamoto nyingi. Aidha imeonyesha jinsi jamii yenyewe inavyojimudu kuzitatua.

Mchango wa Kipekee kwa Mujibu wa Nadharia: Mintarafu ya nadharia, mwandishi bunifu ana uhuru wa kuandika jinsi apendavyo, hailazimu kwamba riwaya zifuate utaratibu mahususi. Hii ni kwa sababu maisha katika jamii ya kisasa hayana utaratibu wowote.
A CRITICAL ANALYSIS OF LAWS AND JURISPRUDENCE ON SALARIES AND REMUNERATION OF PUBLIC AND STATE OFFICERS IN KENYA
Authors: Ochieng Olayo , Kamau Lewis
Published: May 2022

Purpose: This paper aimed at critically analyzing the laws and jurisprudence on salary and remuneration of public and state officers in Kenya.

Methodology: The paper used desk review method. It identified secondary materials related and relevant to study. Particularly, the study journal articles and case laws.

Results: The study found that Salaries and Remuneration Commission, as an independent body under the constitution charged with remuneration of public and state officers has experienced lot of interference from other state agencies. At the same time the commission has in some instance acted ultra vires despite the law providing clearly its mandate.

Unique contribution to theory, practice and policy: To avoid the court battles as a result of interferences, there is need for the commission to have structural engagement with all public agencies and bodies so as to clarify its mandate. Just as the relationship between the national and county governments is based on the principle of consultation and cooperation, the same can be adopted by the commission to ensure effective and efficient service delivery.
INVESTIGATION OF THE CONNECTION OF LYMPHOSARCOMA WITH LATENT TUBERCULOSIS INFECTION
Authors: Lysenko A. P. , Kuchvalsky M. V. , Krasnikova E. L. , Jacobson E. I.
Published: May 2022

DNA and antigens of mycobacteria tuberculosis (MBT) were detected in the cells of the tissues of a goat that fell with signs of lymphosarcoma (sharp hyperplasia of the lymph nodes and spleen, a positive AGID with an antigen or the diagnosis of leukemia - FLK - BLV- bovine leukemia virus). Latent tuberculosis infection was confirmed by the isolation of non-acid – fast MBT (cell wall-cell wall deficient – CWD) from decontaminated and filtered through a sterilizing filter of lymph node and spleen homogenates. In the populations of CWD MBT from lymphosarcomatous tissues a number of characteristic cell varieties were present which were previously found in isolates from the blood of a tuber-culin-positive goat of the same herd, from the lymph node of a BLV-seropositive cow and directly from FLK-BLV.

In the isolates of lymphosarcomatous tissues along with MBT antigens, antigens that reacted with antibodies to BLV and had the same molecular weight as BLV antigens were found, which indicated the existence of a connection between virus-like forms of MBT and oncogenesis.
INFLUENCE OF A NEW COMPLEX PREPARATION ON IMMUNOBIOCHEMICAL INDICATORS OF SHEEP
Authors: Radzivil A. N.
Published: May 2022

The article presents studies to study effect of a new complex drug on immunobiochemical parameters of sheep. In our experiments on use of a new complex veterinary drug virococcid at a dose of 100 mg / kg of live weight, carried out on sheep spontaneously infested with parasitosis, significant positive changes in hematological parameters of blood and in systems of cellular and humoral immunity were revealed, which made it possible to normalize processes of hematopoiesis, which favorably affected clinical state of experimental animals, toxic effect on hepatocytes was not established.
NORMS FOR APPLICATION OF STRAW BEDDING IN SECTIONS FOR KEEPING DRY ANIMALS
Authors: Shamonina A. I. , Shamonina A. I.
Published: May 2022

The article presents the results of research activities to establish the optimal rate of straw bedding in sections for dry animals, an economic assessment is given. For this purpose, the ethological reactions of animals, the comfort of keeping animals and thermometric indicators of the straw bedding were studied.

Experimental studies were carried out in the branch of the Agrofirm «Lebedevo» RUE «Minskenergo» Molodechno region. The objects of research were dry cows and heifers of the Holsteinized Belarusian Black-and-White breed, divided into four groups (1 control and 3 experimental), 30 heads each. The differences between the groups consisted in the amount of straw bedding applied. As a result of the research, it was found that for animals in sections 8×15 m, 4.5 kg/head is optimal, in sections with a division into a feeding zone (3×18 m) and rest (4.5×18 m) – at least 3.0 kg/head.
Сурункали юрак етишмовчилиги декомпенсациясида эрувчан ST2 биомаркери миқдори ва морфофункционал ўзгаришлар орасидаги ўзаро боғлиқлик
Authors: Aбдуллаев Тимур , Ғуломов Хумоюн , Цой Игор , Зияева Aдолат
Published: May 2022

Ушбу мақолада декомпенсацияланган сурункали юрак етишмовчилигида замонавий биомаркер-эрувчан ST2нинг аҳамияти хақида баён қилинган. Сурункали юрак етишмов-чилиги кечиши ва ST2 концентрацияси даражаси ўртаси-даги боғлиқлик таҳлил қилинган.
Novel Class of Central Renin Angiotensin Aldosterone System Inhibitor: Firibastat
Authors: Maheshwari Nidhi , Tayal Vandana
Published: May 2022

Hypertension is one of the most important risk factors for the development of ischemic heart diseases, stroke, disability, vascular dementia, heart failure, renal dysfunction, retinopathy, and premature death. Despite the use of two or more blood pressure lowering medications, a considerable proportion of patients show poor control. Current antihypertensive medications show the limitation of use and effect in obese population, certain races like black population and also in renal impairment. Thus, there is an impending need to develop novel classes of antihypertensive agents acting on new targets with diversified mechanisms of action to more effectively manage raised blood pressure. With the introduction of the recent concept of overactive brain renin angiotensin system in cardiovascular disorders, attempts have been made to identify a molecule with the potential of inhibiting aminopeptidases involved in the formation of Angiotensin III. A novel aminopeptidase A inhibitor, also a prodrug Firibastat is currently undergoing development in Phase III clinical trials for hypertension as well as chronic heart failure. We hereby, provide an updated summary of evidence generated so far with Firibastat and also a glimpse into the therapeutic potential of this novel candidate extending beyond the spectrum of essential hypertension
Effect Of AJI-NO-MOTO On Kidney Of Adult Albino Rat: A

Histopathological Evaluation
Authors: Syed Midhat , Shangloo Prenika , Gupte Bonita , Gupta Sangeeta
Published: May 2022

Introduction: Aji-No-Moto (MSG), the wonder flavoring agent, has been reportedly overused in all packed food products and the cuisines being served in restaurants. This salt effect almost all the organs of the body but the evidences regarding its ill effects are very limited. Thus, no guidelines are there for the safe limits of Aji-No-Moto use. In current study we planned to analyses the histopathological effects of Aji-No-Moto on kidney.

Methods: The study was conducted on 18 inbred adult albino rats of either sex. The rats of control group (C) received only standard diet with distilled water, low dose test group (T₁) rats received 0.5mg/kg of MSG dissolved in distilled water and high dose test group (T₂) rats received 1.5mg/kg of MSG dissolved in distilled water per orally for 28 days. After the experimental period, the rats were sacrificed to dissect out the renal tissue which was later subjected to histological processing and tissue sectioning.

Observations: The kidney tissue sections of the control group (C) revealed normal renal architecture consisting of cortical labyrinth and medulla. The cortical labyrinth consisted of glomeruli, PCT and DCT whereas the medulla consisted of the ascending and descending limbs of loop of henle and collecting ducts. On the other hand, renal sections of low dose group (T₁) showed focal shrinkage of renal glomerulus and widening of the Bowman’s space. Furthermore, these changes were more pronounced in high dose group (T₂) along with hypercellularity of glomeruli, dilatation, hyperaemia and congestion in the intertubular cortical blood vessels and mononuclear cell infiltrate.

Conclusion: Aji-No-Moto is the most widely used flavoring agent whose minimal dose for use has to be evaluated. The current study was planned to access the minimal low dose limit of MSG for use. The results of aforementioned study revealed that even small dose of 0.5mg/kg/day is capable of producing histopathological effects on kidney.
Incidence of Malaria among the Pediatric Age Group Attending to MGM Hospital Warangal
Authors: Amgothu Mohan , Akkala Venu , Bandi Suman , T Jaya Chandra , Vatchala Sudha
Published: May 2022

Background: In India, malaria persist throughout the year and usually the incidence is more during rainy season. This necessitates the use of other laboratory methods to clinch the diagnosis, which is important in view of frequent relapses reported in vivax malaria and hence there is need for radical treatment. Considering all the above factors, a need is felt to evaluate the available lab diagnostic procedures for malaria, and also to know the trend of malaria epidemic at Warangal.

Methods: It was a prospective study, conducted in the department of Microbiology, KMC Warangal. Paediatric age group with fever with chills and rigors followed by sweating were included in this research. Blood sample was collected thick and thin blood smears were prepared, stained by JSB or Leishmans or Giemsa. Parasight 'F' test and OptiMAL tests were used to detect the antigen. Chi square test was used to find the correlation between the parameters.

Results: Total 300 blood samples were collected, malaria positivity was 24%, male female ratio was 1.05, statistically there was no significant difference. In area wise malaria positivity also statistically there was no significant difference. Age wise, maximum cases were diagnosed in 6 – 10 years group. Parasight F test was identified to be highly sensitive in the diagnosis of malaria among the paediatric age group.

Conclusion: Falciparum malaria is identified to be the commonest malaria in this area which effect all the paediatric age groups and gender. Parasight F test was found to be the better technique in malaria diagnosis.
Efficacy of Methylprednisolone and Etoricoxib Combination to attenuate Post-operative
Pain and Nausea/Vomiting in Laparoscopic Surgeries
Authors: Sharma Vivek , Lakhina Kriti , Bankapur Rahul , Lamba Preeti
Published: May 2022

Background and Aims:Pain and PONV (postoperative nausea and vomiting) are common complaints in the period following surgery. A multimodal approach targeting the reduction of postoperative pain with an opioid-sparing analgesic along with an antiemetic medication would minimize opioid consumption and its associated side effects. We evaluated the efficacy of methylprednisolone 125 mg IV taken along with oral 120 mg etoricoxib on postoperative pain and PONV in patients undergoing laparoscopic surgeries

Material and methods:A prospective, randomized, double-blind study was conducted on 70 patients aged between 18 and 60 years with ASA grade 1 and 2 posted for elective laparoscopic surgeries. The test group was given a combination of methylprednisolone 125mgIV (given just before induction)& etoricoxib120mg oral (given 1 hr before surgery). (Group A, n=35) while control group received normal saline IV and a placebo per oral(Group B, n=35). Duration and quality of analgesia was assessed by visual analogue scale (VAS) score at 2,4,6,8,10,12,16,20 and 24hr as primary objective. Total dose of rescue analgesic(injection Fentanyl 50 mcg) in first 24 hours, peri-operative hemodynamic change and post op nausea vomiting (PONV) were observed as secondary objective.

Result:Demographic profiles were comparable. Duration of postoperative analgesia was significantly prolonged(p<0.05) in Group A(7.57±1.04hrs) as compared to Group B(3.05±0.5hrs). Group A showed a significant reduction in postoperative fentanyl consumption in the form of rescue analgesic(p<0.05). Group A also showed significant reduction in the incidence of PONV(p<0.05).

Conclusion:We conclude that single-dose administration of methylprednisolone IV along with oral etoricoxib has better analgesic efficacy in comparison to placebo for patients undergoing laparoscopic surgeries.
Pattern And Prevalence Of Psychiatry Morbidity Among Subjects Attended Psychiatric Outpatient Department In A Tertiary Care Hospital In Northern Telangana
Authors: Rachakatla Shiva Kumar , Porandla Kishan , Puli Sai Krishna , Nadigapu Sanjay Kumar , mavillapalli Vishnu Vardhan , Cheriyala Swetha , Devulapally Namrata
Published: May 2022

Background: Mental health problem is a major public health issue all over the world including India. In India, mental disorders are the leading contributors to significant morbidity and disability amongst those affected. With changing health patterns among Indians, mental behavior and substance use disorders are coming to the forefront in health care delivery systems.

Objective: This study was aimed to assess the diagnostic pattern of psychiatric morbidity among the patients attending psychiatric outpatient department in a private medical college.

Methodology: This cross-sectional study was carried out in the Department of Psychiatry in Prathima Institute of Medical Sciences located at Karimnagar, Telangana, India. For this study, a total of 442 new subjects attending Psychiatry Outpatient Department (OPD) from August 2020 to July 2021 were taken. All the information including longitudinal histories of patients was recorded in files and the diagnosis was made following Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM 5). Socio-demographic parameters and family history of mental illness were collected from the record file of the individual patient.

Results: In the present study, among the different age groups, the majority (28.05%) of the study subjects were of the age ranging from 21-30 years. The distribution according to gender was (62.89%) males and (37.10%) females. The majority of the study subjects belonged to the rural background (69.45%), educated up to 10th standard (28.73%), self-employed (29.86%), married (67.42%), belonged to Hindu religion (85.74%), and with a monthly family income of 5,000 to 10,000 (38.68%). The majority of the study subjects were diagnosed with Major depressive Disorders (28.05%), followed by anxiety disorders (17.87%) and Substance-Related and Addictive Disorders (16.96%).

Conclusion: This study provides information about the prevalence of psychiatric morbidity among patients attending outpatient department in a private medical hospital in Northern Telangana. It helps in assessing the pattern of psychiatric problems and taking necessary steps to plan for better management of mental health care in the near future.
Serum Uric Acid as an Independent Risk Factor for Acute Ischemic Stroke
Authors: Akula Hari Shankar , Cheeti Upender Rao
Published: May 2022

Background: Stroke is a neurological deficit due to acute focal injury of the central nervous system due to any vascular cause. The role of serum uric acid as a risk factor for acute stroke is an area of importance to many researchers. We in the current study tried to determine the levels of serum uric acid in cases of acute ischemic stroke and compare them with those in age and sex-matched controls.

Methods: This hospital-based case-control study was performed in the Department of General Medicine, Prathima Institute of Medical Sciences, Naganoor, Karimnagar. All the subjects were interviewed, examined, and investigated as per the predesigned and pre-tested proforma. Biochemical investigations included estimation of serum uric acid, serum triglycerides, fasting blood glucose, Renal function tests, and Liver function tests.

Results: Mean Serum Uric Acid level was lower in the patients with lacunar stroke as compared to the patients with larger infarcts (6.16 ± 1.68 mg/dl vs. 6.73 ± 2.07 mg/dl). Butthisdifference was not statistically significant as the p-value is >0.05.The correlation between SUA and NIHSS score was studied with the help of Spearman rank correlation. It was found that there was a significant positive correlation between SUA and NIH stroke scale score on admission as well as at the time of discharge (p<0.05 for both).

Conclusion: Elevated serum uric acid level is independently associated with acute ischemic stroke. It was observed that serum uric acid levels were correlated with hypertension, diabetes mellitus, smoking, obesity, and metabolic syndrome. It was found that cases with elevated serum acid levels had poor prognosis and overall mortality rate.
BABY LED WEANING PARA BEBÊS COM SÍNDROME DE DOWN É POSSÍVEL?
Authors: Ferreira de Almeida Ana Paula , Campos de Oliveira Ana Thais , De Sousa Silva Fernanda Tayla , Barreto Amaral Sheyla Maria , Da Silva Alexandrino Silvia Paula , Souto Almeida Cristiane , De Abreu Siqueira Ana Maria
Published: May 2022

Entende-se por alimentação complementar introduzir os alimentos sólidos na dieta da criança para suprir suas necessidades nutricionais a partir dos 6 meses de vida.  A abordagem Baby Led Weaning – BLW vem sendo cada vez mais pesquisada devido a adesão das famílias, inclusive por pais de filhos com Síndrome de Down. Desse modo, o presente estudo teve por objetivo analisar na literatura científica, se é possível e seguro bebês com Síndrome de Down iniciarem a alimentação complementar pela abordagem BLW. O estudo se trata de uma revisão integrativa da literatura. Após o reconhecimento dos artigos, foram efetuados os seguintes passos de seleção:  leitura cautelosa dos títulos, dos resumos e na íntegra, após serem selecionados, foram excluídos os estudos que não estavam de acordo com os critérios de inclusão. Não foi possível identificar se é viável e seguro bebês com Síndrome de Down iniciarem a alimentação complementar pela abordagem Baby Led Weaning.
Images and Metaphors of Mathematics Among University Students
Authors: Osman R. , Hilmi Z. A. G. , Ramli N. , Abdullah N. H. M. , Alam, N. M. F. H. N. B.
Published: May 2022

This paper discusses the images and metaphors of mathematics held by university students through their experiences of learning mathematics and the application of mathematical knowledge in real life. The study involved two hundred and four university students selected using purposive sampling and data was obtained through a question form shared online. The analysis was based on descriptive statistics, namely comparing percentages among the responses, since the measurement level of the data collected was either categorical or ordinal and there was no continuous data collected. The findings indicate that images and metaphors related to mathematics held by university students focused more on physical aspects rather than non-physical. Thus, the lack of understanding and imbalance in mathematics learning involving metaphysical domains needs to be observed in detail.
Solving Fredholm Second Order Integro-Differential Equation with Logarithmic Kernel Using the Airfoil Collocation Method
Authors: Ramdani N. E. , Hadj A.
Published: May 2022

In this paper, the Airfoil polynomials for solving the second order integro-differential equation with a singular kernel is considered. The collocation method is developed to obtain an approximate solution of the equation. We present an error analysis and conclude by providing numerical tests to verify our results.
Hermite-Hadamard Fejér Inequalities for Fractional Integrals for Functions Whose Second-Order Mixed Derivatives are Coordinated Preinvex
Authors: Mehmood S. , Zafar F. , Humza H. , Rasheed A.
Published: May 2022

The main aim of this article is to establish some new refinements of Hermite Hadmard type inequalities via coordinate preinvex functions for fractional integrals. Here we give special cases to our results.
Coloniality of english teaching in the global south: interculturality, power relations and identity
Authors:   , R'Boul Hamza
Published: May 2022

The global spread of English has been critically examined under the lenses of linguistic imperialism, coloniality and interculturality. In particular, intercultural relations have been shaped by power imbalances that have resulted in colonial-like relations between the Global North and South. One manifestation of these power inequalities is the supremacy of Anglophone cultures and their possible hegemony over local languages and cultures. Therefore, it is necessary to explore how English language teaching (ELT) may be promoting hegemonic understandings of English and its associated cultures, especially considering the domination of Anglophone countries on ELT theory and practice. Current scholarship on the cultural politics of English language teaching often argues that non-native English language teachers may contribute to the marginalization of their own languages and culture through presenting Anglophone cultures as superior. Students may perceive the attempt to achieve a native-like competency as conditioned by their adoption of native speakers’ ways of languaging and culture. This research has been conducted in Morocco, where English is increasingly spreading and, thus, gradually used as a lingua franca to mediate intercultural and international contacts. A lingua franca refers to a language that is used as a common language between speakers of different native languages. The rationale for conducting this doctoral research in Morocco comes from its sociolinguistic situation which is marked by the linguistic dependency of foreign languages and the rapid spread of English. Morocco is a postcolonial space that has been characterized by linguistic dependency, which started with the French and it seems it could be perpetuated by the supremacy of English. That is why this research would allow for a better understanding of how English is influencing the cultural identity of both teachers and students. My thesis explores the intersection of language, power, culture and identity through the combination of four articles. These studies have sought to examine various ways in which the global spread of English and its teaching may be contributing to the maintenance of power imbalances between the Global North and South. This thesis will discuss (a) how the global spread of English is both a manifestation and a mechanism in perpetuating power imbalances, (b) the impact of the supremacy of Anglophone cultures on Southern cultures and identities and (c) how colonial-like intercultural relations should be adequately addressed in English teaching classrooms. This thesis will argue for the necessity of reimagining the traditional understandings of the global spread of English and ELT through more critical engagement with intercultural communication dialectics and power imbalances between the Global North and South.
A Novel Approach of Marine Ecosystem Monitoring System with Multi-Sensory Submarine on Robotic Platform for Visualizing the Climate Change Effect over Oceanic Environment
Authors: Banerjee Sheekar , Jhumur Aminun Nahar
Published: May 2022

It is obvious that the whole world is so much concerned about the terrifying escalation of climate change in the recent time period. This climate change effect can be visible in the land, atmospheric and oceanic area simultaneously. Though there have been multiple attempts of proposing solutions concerning the protection for the land area environmental balance, monitoring and surveillance. But unfortunately there have been a very handful of research work which predominantly concerns about the protection upon the environmental state of marine biological species and its ecosystem. So, the following research study proposes a solution which appears to be a full-fledged Bluetooth controlled Submarine prototype with a sensory chipboard attached inside its endo-skeleton which contains multiple sensors like DHT11 temperature-humidity, dust, CO2 and YL69 pH sensors. The sensory data provides the information of underwater whether the naval environment is habitable for the marine biological species or not, under the terrible effect of global climate change. The submarine prototype is fully functional in the surface and underwater scenario which contains a very unique mechanical design and circuitry with an exceptional sensor data streaming capability which can be used by marine biological researchers and oceanographers professionally as a full-fledged marine ecosystem monitoring device.

HIGHLIGHTS

Climate change is causing a very alarming effect in the oceanic area which is constantly threatening the future of marine biological species. The paper focuses on the constant monitoring over spacies with the help of a multi-sensory submarine with real time sensory data and remote navigation

The unique clustering of multi-sensory circuity makes the sensory data more reliable while the vacuum controlled hydraulic pump motors make the navigation and diving of the submarine prototype very preciseand swift

The navigation can be controlled with a globally unique and customized Submarine Navigator Smartphone Application

The multi-sensory marine species monitoring submarine prototype appears to be a torch-bearer of the amalgamation of the fields such as IOT-Sensors and Robotics which paves the way for further IOT and Naval Robotics Research

GRAPHICAL ABSTRACT
Comparison Study of Time Domain Reflectometry (TDR) Measurement Methods for Detecting Wire Interconnect Related Open-Contact and Short-Contact Failures in Power Semiconductor
Authors: Ng Kiong Kay , Soo Yew Guan
Published: May 2022

Open-contact and short-contact are 2 common failures that causing power semiconductor to have electrical malfunctioned. One of the reasons of these failures relate to defective in the wire interconnect. Time domain reflectometry (TDR) is a common method widely used to detect failures in semiconductor devices. This study focused on comparing 3 different TDR measurement methods in detecting wire related open and short failure for power semiconductor, namely Single-Ended method, Single-Pin Grounded method and All-Pin Grounded method. A special custom-made jig is used during the measurements to ensure all the methods are measured under the same conditions. This study shows that all the 3 TDR measurement methods are able to detect wire related open and short failures in power semiconductor. The Single-Pin grounded method is the preferred method because it is easy in term of setup and having the good capability in detecting both open and short failures. Furthermore, the study also shows that the TDR is able to detect the location of open and short failures that is not able to achieve by using the conventional electrical testing method.

HIGHLIGHTS

Comparison study on Single-Ended, Single-Pin Grounded and All-Pin Grounded TDR measurement methods in detecting open-contact and short-contact failure in power semiconductor

The study shows Single-Pin Grounded TDR measurement method is the preferred method since it is easy in term of setup and able to detect both the open-contact and short-contact failures

TDR measurement method is also able to locate the location of open-contact and short-contact failures

GRAPHICAL ABSTRACT
Design and Numerical Analysis of Rectangular Sonotrode for Ultrasonic Welding
Authors: Kothuru Venkata Vara Lakshmi , Sistla Venkata Subrahmanyam , Mohammed Irfan Hussain , Jagana Arvind
Published: May 2022

Ultrasonic welding is a fast, clean and high energy process, no flux or filler metal is required, longer tool life and greater efficiency of a weld can be achieved in just a few seconds. Limited length and thickness of weld are the main drawbacks in this process. Welding of large length and thickness materials leads the ultrasonic welding applications unlimited. The design of the components like booster and sonotrode or horn in ultrasonic welding plays a vital role to improve the length and thickness of the welds by generating uniform amplitudes. In the present work, an ultrasonic sonotrode is designed to improve the weld length with suitable uniform amplitudes on the weld bed surface. The design of sonotrode is significantly difficult to obtain the uniform amplitudes at the large weld length. Here, rectangular sonotrode with multiple slots is designed based on theoretical calculations and numerical analysis is performed to obtain the maximum possible weld lengths with uniform amplitudes at a known operating frequency. The finite element method is used to analyze the actual resonating frequency and amplitude distribution of the sonotrode and obtained the maximum weld length as 400 mm for 15 kHz frequency with 3 slots.

HIGHLIGHTS

One of the major drawbacks in ultrasonic welding is limited length and thickness of weld. Welding of larger length and thickness improves the ultrasonic welding applications.

Modal and harmonic analysis conducted in order to find the dynamic behaviour of the sonotrode.

The increase in the weld length of the sonotrode deviates the amplitude distribution within the sonotrode. To overcome this non-uniform amplitude distribution, longitudinal slots are provided in the sonotrode. Also, these slots reduce the weight of the sonotrode.
Loan Approval Prediction Model Using Customer Behaviour
Authors: Prof. (Mrs.) M. P. Desai  , Sagar Dhawane  , Sagar Dhawane  , Ankita Basare  , Vinod Jairmod
Published: May 2022

Nowadays bank and bank data are very important. In this covid-19 era, people need money a lot, so people are applying for more loans now than before. It is necessary but it is difficult to check all this. Often wrong selections of data can result in loss to the bank. If this data is accurate the bank gets profit. Banking industry always needs a more accurate predictive modelling system for many issues. The bank can earn money from the interest on the credit card used in the loan approval process. All this require a real based application model to be accurate and this model is made using machine learning (ML). In India, the large number of people applying for the loans for various purpose of reasons. The bank employees are not able to analyses or predict whether the customer can payback the amount or not (good customer or bad customer) for the given interest rate. Besides of Credit Score, we believe there are other factors which should be taken in consideration while taking a decision on loan approval. This model is capable of doing that using machine learning algorithm to predict that whether a customer should be provided loan or not.
Fire Detection with Image Processing using Live Camera
Authors: Rushikesh Bhujbal  , Rushikesh Shinde  , Pappu Talwar  , Akshay Raykar  , Prof. Shailesh Bendale
Published: May 2022

People's safety and property can only be saved if the fire alarm signal is precisely detected and identified as early as possible in the fire, which is a terrible catastrophe for the security of people's lives and properties. Fire detection accuracy and validity are degraded as a result of growing ambiguity in the fire signal. – An algorithm for the detection of one dimensional fire space is provided to demonstrate the suggested method's fine fault tolerance, robustness, and accuracy in a novel technique for detecting uncertainty fire signals based on fire scenarios. First, an analysis of fire scenario performance yields a fractal character for the fire space, and then an intelligent method based on rough set theory and trend integration is used to process the multi-source signal obtained from a group of fire detectors. When a relationship between the two characters is recognised as being logically coincident, an actual alarm for a fire is triggered.
Vehicle To Vehicle Communication Using LiFi Technology
Authors: Kaarthick Saran. S  , Keerthivasan. V  , Parthiban. D  , Pradeep. P  , Dr. C. Amali
Published: May 2022

The goal of the project is to reduce the consequences of accidents in our daily lives and to prevent automobile collisions. There are a variety of reasons for such a bad situation that leads to death or disability. This involves a driver’s rapid lack of concentration, braking failure, and loss of stability. Li-Fi is an advanced technology. This project is focused on vehicle-to-vehicle communication in order to prevent traffic accidents. We use ultrasonic sensor, vibration sensor, LCD display, Li-Fi transmitter and receiver. In case of an abnormal condition in the front vehicle, the vehicle at the back will be intimated and will slow the speed on the second vehicle. Many automakers are currently focusing on developing automobiles with IoT capabilities, including health care,accident prevention, vehicle safety, driver safety, driver and passenger comfort, vehicle monitoring, etc. In this project we focused on developments in driver’s drowsiness and comfort monitoring. If driver is not alert for obstacles or in front of vehicles then the speed of engine will decreased through LIFI technology and the engine speed will slowdown to stop condition and the project having alert system such as buzzer to intimate through sound. This project would be giving in- depth knowledge on recent developments in the field of automotive.
Lora Based Renewable Energy Monitoring System
Authors: Mr Laxman Thomase  , Mr Vaibhav Bhosale  , Mr Siddhesh Pawar  , Mr Ritesh Jawalkar  , Prof. Vivek D Bavdhane
Published: May 2022

The world economy is growing rapidly, and global energy demands are predicted to increase even more in the future. Energy is expected to get more expensive, in turn affecting the economic development. Energy demand can be reduced by employing efficient Energy Management Systems (EMS). The development of wireless communication technology in the last decade has made wireless communication protocols exclusive in the domain of sensor networks. Existing trends have encouraged the use and implementation of many radio-based protocols due to fact that short-range the radio transmission is inexpensive, secure and easily available. Therefore, the objective of this project is to design and implement a LoRa based Wireless Sensor Network for conventional energy monitoring system capable of intelligently monitoring parameters such as wind and solar.
Transaction Using Facial Authentication and Random PIN Generation
Authors: Dr Vanathi B  , Rex Peter G  , Premnath S  , Sunil Kumar S  , Sakthevel B
Published: May 2022

In this paper we are going to develop a robust automated web application for transacting money in higher level security purpose with high facial recognition. First we have to register our personal details with our face and pass the liveness detection test. Haar cascade-based algorithm has been applied for fast and simple face detection from the input image. The face image is then being converted into grayscale image. After that, the iris, eyebrows, nose, mouth of candidates are extracted from the intensity valleys from the detected face it will consider as datasets now our system can understand who are all authorized and unauthorized. While login our face will be recognized if we authorized will can move to authorized page else our system won’t allow to login. For higher security purpose we have used face recognition module. During the transaction our face will be recognized it will allow only the authorized account holder to transact a money, it doesn’t allow others to transact a money.