bluuebunny/crossref_metadata_2025 huggingface dataset:
From cadet to professor: service of physiology (to the 80th anniversary of V.N. Golubev)
Authors: Alexandrov Mikhail V. , Filippova Elena B. , Antonenkova Elena V.
Published: January 2023

This paper describes the main milestones of the work and scientific and pedagogical activities of Professor Viktor Nikolaevich Golubev. V.N. Golubev was born on September 22, 1942, in the town of Sharya, Kostroma Region, in the family of a military paramedic. In 1961, after graduating from the Tambov Suvorov Military School, he entered the faculty of training doctors for the missile and ground forces of the Military Medical Academy of S.M. Kirov. According to the suggestion of an academic worker, he held the position of senior doctor of the engineer-sapper regiment in the city of Ussuriysk. Since 1970, his fate has been inextricably linked with the Department of Normal Physiology of the Academy, within the walls of which he has gone from adjunct to Professor and head of the department. It is here that V.N. Golubev joined the ideas of the great physiological school of Sechenov-Pavlov, starting his scientific activity under the guidance of Professor A.S. Mozzhukhin. His studies were devoted to the physiology of military labor and aimed at maintaining the stable professional performance of servicemen. Since 1988, V.N. Golubev headed the Department of Biomedical Disciplines of the Military Institute of Physical Culture, where he introduced modern achievements of sports medicine and physical rehabilitation into the educational process. At the Military Institute of Physical Culture, his research interests focused on the physiological mechanisms of motor activity, i.e., the physiology of sports. In 1992, V.N. Golubev successfully defended his doctoral dissertation, which solved the problem of controlling motor activity in extreme conditions. He was awarded the title of Professor in 1993. Since 2001, V.N. Golubevs scientific and pedagogical activities have again connected with the Department of Normal Physiology of the Kirov Military Medical Academy, which he headed from 2018 to 2021. Viktor Nikolaevich actively participated in the development of standards of professional employment of the teaching staff of the academy, and he was one of the founders of military psychophysiology in the Armed Forces of the Russian Federation. V.N. Golubev authored of more than 450 scientific papers, including 5 textbooks, 8 monographs, and 56 educational and teaching aids. For nearly half a century of service in the Armed Forces, V.N. Golubev has come a long way from a Suvorov soldier, a colonel of the medical service and to a Professor. In all the positions he held, he proved himself to be a principled person, actively related to life, and a highly professional specialist in his field.
Academician Nikolay Anatolyevich Maistrenko (to the 70th anniversary of his birthday)
Authors: Romashchenko Pavel N. , Kurygin Alexander A. , Dovganyuk Vitaly S.
Published: January 2023

Nikolay Anatolyevich Maistrenko is a prominent specialist in the field of abdominal and endocrine surgery, oncology, and organization of specialized surgical care. For 24 years, he headed the Department and Clinic of Faculty Surgery named after S.P. Fedorov Military Medical Academy of S.M. Kirov. With his direct participation in the clinic, the structural units became modernized, which were equipped with modern equipment to provide high-tech surgical care. Under the direction of Academician of the Russian Academy of Sciences N.A. Maistrenko, the range of scientific research conducted in the clinic and together with other research institutions of Saint Petersburg (i.e., Research Institute of Oncology named after N.N. Petrov, Institute of Physiology named after I.P. Pavlov, and Research Institute of Emergency Medicine named after I.I. Dzhanelidze) has significantly expanded. The main areas of scientific activity of Professor N.A. Maistrenko are the development of organizational, tactical, and technical issues of providing surgical care to patients with gastroenterological profile; study of long-term results of organ-preserving operations and resection interventions for complicated gastric and duodenal ulcers; research on the problem of choledocholithiasis using laparoscopic, endoscopic, and non-surgical methods of its elimination; introduction of new diagnostic and therapeutic technologies in surgical endocrinology; study of the possibilities of laparoscopic interventions in emergency surgery of acute diseases and abdominal organ injuries; development of topical aspects of colorectal surgery using new technologies when performing sphincter-preserving operations; and surgical treatment of chronic pancreatitis. Academician N.A. Maistrenko is the author and co-author of more than 750 scientific papers, including 28 monographs and manuals. Under his direction, 13 doctoral and 19 masters theses were defended. Eighteen teaching aids, workshops, and lectures have been published on various sections of endocrine and abdominal surgery. Nikolay Anatolyevich Maistrenko is a vivid example of how aspiration, diligence, and discipline ensure the achievement of the highest goals, and love for his specialty guarantees great professional success.
Source character of microseismicity in the San Francisco Bay block, California, and implications for seismic hazard
Authors: Olson Jean A. , Zoback Mary Lou
Published: January 2023

We examine relocated seismicity within a 30-km-wide crustal block containing San Francisco Bay and bounded by two major right-lateral strike-slip fault systems, the Hayward and San Andreas faults, to determine seismicity distribution, source character, and possible relationship to proposed faults. Well-located low-level seismicity (Md ≦ 3.0) has occurred persistently within this block throughout the recording interval (1969 to 1995), with the highest levels of activity occurring along or directly adjacent to (within ∼5 km) the bounding faults and falling off toward the long axis of the bay. The total seismic moment release within the interior of the Bay block since 1969 is equivalent to one ML 3.8 earthquake, one to two orders of magnitude lower than activity along and within 5 km of the bounding faults. Focal depths of reliably located events within the Bay block are generally less than 13 km with most seismicity in the depth range of 7 to 12 km, similar to focal depths along both the adjacent portions of the San Andreas and Hayward faults. Focal mechanisms for Md 2 to 3 events within the Bay block mimic focal mechanisms along the adjacent San Andreas fault zone and in the East Bay, suggesting that Bay block is responding to a similar regional stress field. Two potential seismic source zones have been suggested within the Bay block. Our hypocentral depths and focal mechanisms suggest that a proposed subhorizontal detachment fault 15 to 18 km beneath the Bay is not seismically active. Several large-scale linear NW-trending aeromagnetic anomalies within the Bay block were previously suggested to represent large through-going subvertical fault zones. The two largest earthquakes (both Md 3.0) in the Bay block since 1969 occur near two of these large-scale linear aeromagnetic anomalies; both have subvertical nodal planes with right-lateral slip subparallel to the magnetic anomalies, suggesting that structures related to the anomalies may be capable of brittle failure. Geodetic, focal mechanism and seismicity data all suggest the Bay block is responding elastically to the same regional stresses affecting the bounding faults; however, continuous Holocene reflectors across the proposed fault zones suggest that if the magnetic anomalies represent basement fault zones, then these faults must have recurrence times one to several orders of magnitude longer than on the bounding faults.
Estimation of source parameters and Q from acceleration recorded in the Vatnafjöll earthquake in south Iceland
Authors: Ólafsson Símon , Sigbjörnsson Ragnar , Einarsson Páll
Published: January 2023

The earthquake in Vatnafjöll, 25 May 1987 (M = 5.8), was the largest earthquake in south Iceland since 1912 (M = 7), and it was one of the first earthquakes recorded on a local network of strong-motion acceleration recorders. In this study, the strong-motion records are used to obtain an estimate of the source parameters and the attenuation of high-frequency waves. The source parameters are obtained by fitting the data by a dislocation source model combined with an exponential model for the attenuation. The root-mean-squared acceleration is also estimated and compared to predicted values using the source parameters. The source parameters estimated here (M0 = 8.2 × 1024 dyn-cm, r = 4.6 km, Δσ = 38 bars, Δu = 36 cm, Td = 3 sec) and estimated moment magnitude (Mw = 5.9) agree well with values obtained previously from teleseismic waves and strain-meter data. Estimates of path-averaged crustal shear-wave quality factors give results in the range Q = 128 to 425, and k = 0.05 sec for the spectral decay parameter, confirming recent measurements of higher crustal Q for this region than in earlier studies.
On the mechanism of conversion of seismic waves to and fromTwaves in the vicinity of island shores
Authors: Talandier Jacques , Okal Emile A.
Published: January 2023

High-frequency seismic records from the Polynesian Seismic Network are used to investigate in detail the processes of conversion of acoustic (T-wave) energy from and to seismic waves at island shores. On the source side, we study the seismic-to-acoustic conversion based on T phases from Hawaiian events recorded at Polynesian stations located on the coral platter; on the receiver side, we study the acoustic-to-seismic conversion based on T phases from marine sources recorded across the Polynesian islands. In both instances, our results underline the importance of steep slopes (typically 50°) in allowing an efficient conversion between P waves in the island structure and T waves in the water column. These slopes can be coral reefs or the heads of young, presumably unconsolidated, basalt flows. Under this geometry, modeling based on raytracing indicates that the seismic record of the T phase consists of a P wave at distances from the conversion point greater than 9 km; at shorter distances, S waves and surface waves are generated. In the absence of a steep slope, only surface waves are present. These models can be used to compute precise and predictable travel-time station corrections, allowing the use of seismometers located inland to exploit the superb detection and location capabilities of T waves.
The The Role of Executive Functioning in Understanding Chronic Pain Experiences in Adolescence: A Pilot Multi-Method Study
Authors: Caes Line , Wallace Ewan , Duncan Christina , Dick Bruce
Published: January 2023

Background: Optimal executive functioning is pivotal to successful self-management of chronic pain (e.g., by being able to adapt self-management behaviours to changing situations), thereby contributing to improved health-related quality of life. However, preliminary evidence points to impaired executive functioning in people with chronic pain. Despite adolescence being identified as a sensitive period for the development of appropriate self-management and executive functioning skills, little is known about the associations between chronic pain and executive functioning performance in adolescents. The aim of the study was to pilot a multi-method approach to compare executive functioning, chronic pain, and quality of life between adolescents with and without chronic pain. Methods: A sample of 22 adolescents with chronic pain (12-18 years, 82% female, mean chronic pain duration = 6.68 years) and 13 pain-free adolescents (age and sex matched) participated. All participants completed a battery of neuropsychological tasks to assess the three key executive functioning components (i.e., inhibition, working memory and cognitive flexibility) and provided self-report on their executive functioning, pain experiences and health-related quality of life. Results: In addition to confirming the feasibility of the methods, data revealed that 23-62% of adolescents with chronic pain showed problematic performance, using normative scoring, in all three executive functioning components and showed significantly lower performance on all three executive functioning components compared to pain-free adolescents. Self-reported, but not neuropsychologically assessed, working memory and emotional control difficulties were associated with more pain-related interference and lower health-related quality of life. Conclusion: These preliminary findings reveal the critical need to screen for and address any potential deficits in executive functioning in adolescents with chronic pain to optimise their self-management of pain and subsequent health-related quality of life. The findings also illustrate the feasibility of and need for future systematic, multi-method and prospective investigations in larger samples to further clarify the cyclical associations between chronic pain and executive functioning in adolescents.
The Hookah, an Emerging Form of Smoking, Systemic Effects and Harmful Effects of Its Use
Authors: Oliveira Ellen , Assunção Gabriela , Tavares Marcos , Carvalho Carlos , Barbas Carmen
Published: January 2023

Hookah originates from India and in the last years spread around the world. The culture and the mystique behind this device promoted the use among the young population. Despite the thought that is the new safe way to smoke tobacco, recent studies showed that it can be more harmful than the cigarette, becoming a public health problem. Hookah increases airway reactivity and inflammation, causing an inflammation in the respiratory and cardiovascular system. The inhaled smoke contains chemicals agents that are toxic to the lung. As known in the literature the inhaled substance can lead to an acute eosinophilic pneumonia with a pulmonary interstitial infiltrate on radiological image. The degree of pulmonary involvement is varied and may cause a serious condition, requiring hospital admission and intensive care support. The treatment consists of ceasing the hookah use and the use of systemic corticosteroids. One important damage to the health is the infection disease like the tuberculosis transmission, cause by sharing the devise. In the cardiovascular system, the alterations were increasing the cardiac frequency and blood pressure in addition to causing inflammation in the endothelium of the vessel. Long-term studies are needed to correlate the use of this device with the risk of developing cancer.
Alemtuzumab-Induced Secondary Autoimmune Skin Disorders as Side Effects of Multiple Sclerosis Therapy: Problem That Can Be Influenced or Fate? A Narrative Overview of The Literature A Neuroprotective Role of Vitamin D?
Authors: Goischke Hans-Klaus
Published: January 2023

At present, no cure for multiple sclerosis can be made possible with the pharmaceuticals available, nor can a gradual progression of multiple sclerosis be prevented. In the management of multiple sclerosis, it is therefore necessary to determine existing autoimmune diseases through anamnesis before starting alemtuzumab therapy with disease modifying therapy. With previously existing autoimmune diseases or as prophylaxis, comorbidities can be influenced by vitamin D supplementation. Secured pathophysiological and immunological mechanisms of vitamin D on autoimmunological processes support the daily, individually high-dose oral vitamin D intake. This add-on therapy should positively influence the quality of life of persons with multiple sclerosis in the long term. So that the patients do not reject the highly efficient multiple sclerosis therapy for fear of side effects, this therapy offer is a way of avoiding side effects of alemtuzumab administration, such as alopecia, vitiligo, and thyroid diseases, and of decisively influencing the course of MS. This increases the compliance of the persons with multiple sclerosis in therapy. The pathophysiological mechanisms of alopecia and vitiligo are shown. The immunological mechanisms of vitamin D and its influence on autoimmune diseases are described. The previous use of vitamin D in the therapy of these skin diseases is presented and oral supplementation is put up for discussion. The additional neuroprotective effect is evident. Preventing infection with oral vitamin D supplements, particularly in coronavirus disease 2019, may prevent or mitigate multiple sclerosis exacerbations.
Cutaneous Manifestations of Breast Cancer Patients in Combination with Capecitabine and Lapatinib Chemotherapy
Authors: Sulistianingrum Nita Damayanti , Indrastuti Niken , Wirohadidjojo Yohanes Widodo
Published: January 2023

The combination of chemotherapy with lapatinib and capecitabine in human epidermal growth factor receptor 2 (HER2) positive breast cancer is quite effective. The combination of these two agents increases the risk of dermatological toxicities. A woman, 38 years old, HER2 positive breast cancer with a combination of chemotherapy agents between lapatinib and capecitabine gives an overview of skin toxicities such as acneiform eruptions, palmar-plantar erythrodysesthesia (PPE), and paronychia. Therapy, in this case, aims at clinical improvement. The combination of lapatinib and capecitabine has a side effect profile like each drug. Combined use of the two agents increases the incidence of skin side effects, including acneiform eruptions, PPE, and paronychia, compared to monotherapy. Early awareness of the side effects of chemotherapeutic agents is needed for early treatment to prevent the worsening of the condition and discontinuation of chemotherapeutic agents due to drug side effects.
DETERMINATION OF MORPHOMETRY AND VOLUME OF THE INTERNAL AUDITORY CANAL
Authors: Bilir Abdülkadir , Fazlıoğulları Zeliha , Tatar Mehmet , Nayman Alaaddin
Published: January 2023

OBJECTIVE: The internal auditory canal (IAC) also known as internal acoustic meatus is a bone channel that connects the internal ear to the posterior cranial fossa. The mean length is approximately 1 cm. The edge of the IAC is called internal acoustic pore (IAP), and the edge of this aperture is blunt and rounded. Important formations such as facial nerve, vestibulocochlear nerve, labyrinth artery and labyrinth vein pass through the IAC. In addition, on the precise determination of the morphometry in surgical interventions on the temporal lobe, MAI is vital. Therefore, in this study, it was aimed to determine the morphometry and volume of MAI.MATERIAL AND METHODS: The study was carried out on the CT images of 210 individuals randomly from the normal population between the ages of 10-90. Morphometric measurements of IAC (lateral angle (LA), canal length, anteroposterior (AP), diameter of IAP, distance from IAP to vestibular aqueduct (VA)) were performed. In addition, the shape and volume of IAC was determined in this study. Cases were divided into 7 different subgroups, 10-14, 15-20, 21-30, 31-40, 41-50, 51-60 and 61 years old, depending on their age.RESULTS: In this study, CT images of 210 patients were analyzed. The mean length of the MAI was 9.5±1.6mm, the AP diameter was 6.3±1.5mm, the distance from the entrance part to the VA was 15.1±6.64mm, the volume was 290±120mm3, and the LA was 50±14º.CONCLUSIONS: When the outcome data were compared by gender, it was found statistically significant that the right AP diameter was higher in men, the length of the right MAI and both sides LA were higher in women. In addition, when the volumes of MAI were compared by age groups, it was determined that the 10-14 age group was smaller than the other age groups.
EVALUATION OF THE PATIENTS OPERATED WITH VSDs OF DIFFERENT AGES
Authors: Çolak Abdurrahim , Becit Necip , Kaya Uğur , Ceviz Munacettin
Published: January 2023

OBJECTIVE: Ventricular septum defect (VSD) can be defined as one or more openings located in the septum separating the left and right ventricle. Ventricular septal defects can be congenital or acquired. It is the most common congenital heart anomaly. In this article, we evaluated the VSDs that we treated surgically in our clinic in the light of the literature.MATERIAL AND METHODS: 68 VSD patients were intervened in our clinic. 39 cases were male (57.3%) and 29 cases were female (42.7%). The mean age was 9.10 ± 9.13 (1-48), and the mean weight was 25 ± 16.5 (7-75). When the preoperative New York Heart Association (NYHA) functional capacity (FC) was compared, FC-I was determined as 31 cases (45.5%), FC-II as 30 cases (44.1%), and FC-III as 7 cases (10.2%). The most common preoperative existing anomalies were 15 cases (22.05%) with aortic insufficiency (AR) and aortic valve prolapse (AVP); 18 cases (26.4%) ASD and 8 cases (11.7%) with PDA.RESULTS: When looking at the intervention methods according to VSD types, the most common cases of perimembranous type were right atriotomy in 53 cases (77.9%), right atriotomy in 1 case (1.4%) and tricuspid septal annulus radial incision; 8 cases of muscular type (11.7%) and right atriotomy and left ventriculotomy in 2 cases (2.9%) of Swiss-Chess type; Right ventriculotomy was preferred in 4 cases (5.8%) of DCJA (Doubly Committed Jukstaarterial) type. Between postoperative complications the most frequent one was residual VSD in 9 patients (15.3 %). Mortality was seen in 3 patients (5.09 %) with preoperative PAB 67±7.5 mmHg, LV- RV shunt 49±9.6 mmHg, Qp/Qs 4.7±3.87, PVR 7.5±4.6 values in follow-up. According to the comparison of the pre/postoperative NYHA and RVP statistics (p<0.05), the survival rate without reoperation was estimated as 93.2 %.CONCLUSIONS: Ventricular septal defect is the most common congenital heart disease. The development of ECHO and cardiac angiography has a great share in the diagnosis and classification. It should be preferred to evaluate the defects very well and close them after 3 months.
THE EFFECTS OF MINIMAL, LOW AND HIGH FLOW ANESTHESIA ON BODY TEMPERATURE AND TISSUE OXYGENATION IN NASAL SURGERIES
Authors: Kesimal Gül , Kazancıoğlu Leyla , Kazdal Hizir , Batçık Şule , Koyuncu Tolga
Published: January 2023

OBJECTIVE: Intraoperative high fresh gas flow may cause Inadvertent perioperative hypothermia (IPH). For this reason, low and minimal flow anesthesia methods that improve the anesthesia climate are applied. We aimed to investigate the effects of minimal, low and high flow anesthesia on body temperature and tissue oxygenation in patients undergoing elective nasal surgery.MATERIAL AND METHODS: Prospective randomized controlled study included 92 patients aged 18-60 years, ASA1-2 operation time 1-4 hours, scheduled for elective nasal surgery under hypotensive anesthesia. The patients were divided into Group 1 (0.5Lmin-1), Group 2 (1Lmin-1) and Group 3 (2 Lmin-1). Demographic and operative data of the patients, preoperative waiting room temperature, intraoperative operating room temperature, intraoperative body temperature, anesthesia breathing circuit humidity and temperature, tissue oxygen saturation, 0th, 15th, 30th, 60th, 90th, 120th, 150thmin and postoperative shivering, Aldrete score, room temperature and body temperatures in the recovery unit were recorded.RESULTS: Perioperative hypothermia developed in all patients (p=0.001). Tympanic temperatures were similar in all three groups (p>0.05). In the subgroup comparison, it was found that the tissue oxygen saturation (StO2) 60 th min value of Group1 was higher than Group 2 (p=0.046). It was found statistically significant that the StO2 90 th min value of Group1 was higher than that of Group 2 and 3 (p=0.013, p=0.013). It was statistically significant that the StO2 120th min value of Group1 was higher than Group 3 (p=0.008).In Group1, postoperativeAldrete score was found to be significantly higher than the other two groups(p=0.002, p=0.002). A correlation was found between operating room temperature, postoperative recovery room temperature, and body temperature(r=.446, p<0.05;r=.531, p<0.01).CONCLUSIONS: Inadvertent perioperative hypothermia developed in all patients who underwent elective nasal surgery with hypotensive anesthesia in minimal, low and high flow anesthesia applications. It was observed that body temperatures, humidity and the temperature of the anesthesia period were similar in all groups. Tissue oxygen saturation was higher in the minimal flow anesthesia group and Aldrete score was higher in the postoperative recovery unit. Minimal flow anesthesia applications can be a good alternative to prevent IPH. However, we think that more studies are needed for the effects of low-flow anesthesia techniques at the tissue level.
COVİD-19 SALGININDA SAĞLIK ÇALIŞANLARINDA DEPRESYON, ANKSİYETE, STRES, TRAVMA DÜZEYİ VE D TİPİ KİŞİLİK: VAKA - KONTROL ÇALIŞMASI
Authors: Kıvrak Yüksel , İnaltekin Ali
Published: January 2023

AMAÇ: Bu çalışmanın amacı COVİD-19 salgınında sağlık çalışanlarında depresyon, anksiyete, stres, virüs korkusu, travma belirti düzeylerini ve D Tipi kişilik ile ilişkisini değerlendirmektir.GEREÇ VE YÖNTEM: Çalışmaya bir Devlet Hastanesi’nde çalışan 50 sağlık çalışanı (22 hemşire, 11 ebe, 4 tıbbi sekreter, 7 sağlık memuru ve 6 doktor) ve kontrol grubu olarak benzer ölçütleri karşılayan, bir özel şirketin müşteri ilişkileri çağrı merkezindeki 89 çalışan dahil edildi. Katılımcılara sosyo-demografik anket formu, Depresyon Anksiyete Stres Ölçeği-21 (DASS-21), D Tipi Kişilik Ölçeği (DKÖ), Olayların Etkisi Gözden Geçirilmiş Formu (OEÖ), Vizüel Analog Skala uygulandı.BULGULAR: Sağlık çalışanı ve kontrol grubu arasında depresyon, anksiyete, stres, travma ve virüs korkusu açısından anlamlı bir fark bulunamadı. Ölçek kesme puanlarına göre sağlık çalışanları grubunda %8 oranında depresyon, %24 oranında anksiyete, %16 oranında stres, %94 oranında travma; kontrol grubunda %20,22 oranında depresyon, %31,46 oranında anksiyete, %22,47 oranında stres, %84,26 oranında travma belirtilerinin olduğu saptandı. D Tipi kişiliği olanlarda olmayanlara göre depresyon, anksiyete, stres ve travma puanları anlamlı olarak daha fazlaydı (sırasıyla p<0,001, p=0,001, p<0,001, p<0,001). Ayrıca D Tipi kişilik puanıyla depresyon, anksiyete, stres, travma arasında ve travma ile depresyon, anksiyete, stres arasında pozitif korelasyon saptandı.SONUÇ: Çalışma sonuçlarımız, hem sağlık çalışanlarında hem de kontrol grubunda belirli düzeyde depresyon, anksiyete, stres ve travma olduğunu, ayrıca D Tipi kişilik özelliklerinin daha yüksek depresyon, anksiyete, stres düzeyi ve travmayla ilişkili olduğunu göstermektedir.
HİPERTROFİK KARDİYOMİYOPATİLİ HASTALARDA EGZERSİZ EKOKARDİYOGRAFİ VE NT-PROBNP DÜZEYLERİNİN DEĞERLENDİRİLMESİ
Authors: Gürsoy Erol , Baydar Onur
Published: January 2023

AMAÇ: Hipertrofik kardiyomiyopatili (HKM) hastalarda anormal sol ventrikül diyastolik fonksiyonu ve NT-proBNP seviyeleri gösterilmiştir, ancak egzersiz hemodinamiği hakkında bilgi eksikliği vardır. Bu prospektif çalışmada, HKM hastalarında diyastolik fonksiyonun prognostik değerini ve NT-proBNP düzeylerinin egzersize yanıtını incelemeyi amaçladık.GEREÇ VE YÖNTEM: Nonobstrüktif HKM tanısı almış 20 hasta (yaş: 52,6±11,3 yıl; n=12 (%60) erkek) ve 11 gönüllüye (yaş: 46,4±13,0 yıl; n=8 (%72,7) erkek) bisiklet ergometrisi ile egzersiz (25 –W, 2 dakika) testi yapıldı. Mitral akım (E/A oranı), septal mitral akım hızları (E/E' oranı) ve NT-proBNP seviyeleri istirahatte ve submaksimal egzersizde ölçüldü. Ayrıca hastalar dört yıl boyunca takip edildi.BULGULAR: HKM hastalarında istirahatte daha yüksek E/E' oranı ve NT-proBNP seviyeleri tespit edildi (E/E'oran: 15,36 ±4,90 vs 7,97± 1, 44; p< 0,001, NT-proBNP: 348,25±215,71 pg/ml vs 37,27±11,93 pg/ml; p<0,001). Egzersiz ile kontrollerde anlamlı bir yükselme olmadı, ancak HKM'li hastalarda E/E' oranı ve NT-proBNP seviyeleri anlamlı olarak arttı (E/E' oranı: 23,83±10,85 vs 8,01±2,22 p<0,001, NT-proBNP: 591,25±276,28 pg/ml vs 40,0± 12,03 pg/ml; p<0,001). Ayrıca dört yıllık takipte hiçbir hastada ölüm gözlenmedi.SONUÇ: Nonobstrüktif HKM hastalarında diyastolik disfonksiyon, yüksek dolum basınçları ve NT-proBNP seviyeleri gözlendi ve bu anormalliklerin maksimum egzersiz sırasında kötüleştiği saptandı. Fakat bu bulgularımız mortaliteyi öngörmedi.
AN EVALUATION OF DIETARY APPROACHES USED IN THE CLINICAL MANAGEMENT OF RHEUMATOID ARTHRITIS
Authors: Saraç Dengizek Merve , Yeşilkaya Burcu
Published: January 2023

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by systemic inflammation, persistent synovitis, and other comorbidities, that affects 0.5-1.0% of the overall population. Long-term active RA causes severe joint damage, disabling pain and diminished life quality. The etiology of RA is not accurately understood, but it is thought to be due to an interaction between the responses of the innate and acquired immune systems. RA is characterized by the presence of Rheumatoid Factor (RF) and anti citrullinated peptide antibodies in the blood circulation. Also the composition of intestinal the gut microbiome is claimed to be critical in immune responses associated with RA. Changes in the microbiota are thought to be related to the risk and severity of the disease. Three regions; primarily the lungs, oral mucosa and gastrointestinal tract have been associated with changes in the microbiota. Commonly, the pharmaceutical treatment of RA includes non-steroidal anti-inflammatory drugs (NSAIDs) that are used to manage the pain and inflammation associated with RA and disease-modifying anti-rheumatic drugs that reduces pain by slowing down the disease. Unfortunately, remission is not likely in many patients. Moreover, side effects related to drugs are commonly reported. Some alterations in the patients’ life and environment are thought to aggravate symptoms, thus influencing severity of RA. For example RA patients, the participants asserted that consumption of red meat, alcoholic and non-alcoholic beverages worsen their symptoms, while nutrients such as fish and blueberries help alleviate the symptoms. To manage the adverse effects of RA, particular dietary alterations are suggested to be effective in reducing inflammation, increasing antioxidant levels, and improving lipid profiles. Antigenic load and food intolerance are thought to play a role in both the onset of Rheumatoid Arthritis. Besides, it has been shown that the intestinal mucosa of the patients would have become more permeable to allergens due to long term NSAIDs use. In this sense, Elimination Diet, Mediterranean Diet, Vegan/Vegetarian Diet approach, Omega-3 Fatty acids, Vitamin D and probiotic supplementation is thought to reduce disease activity. The purpose of this review is to evaluate the efficiency of certain dietary approaches and supplements used for lessening the RA related symptoms, based on the scientific evidence found in the literature.
SHEAR WAVE ELASTOGRAPHY FINDINGS IN GLAUCOMA PATIENTS
Authors: Hekimoğlu Azad , Ergun Onur , Şanal Dogan Aysun , Berk Ergun Şule , Acar Mutlu , Gürdal Canan , Hekimoğlu Baki
Published: January 2023

OBJECTIVE: Our aim is to measure the stiffness values in different regions of the eye with shear wave elastography (SWE) in patients with glaucoma and to compare the results with healthy eyes to investigate whether there is a change in the elasticity of the ocular compartments in glaucoma patients.MATERIAL AND METHODS: In this study, we compared 12 patients with open-angle glaucoma and 32 healthy volunteers using an SWE-equipped ultrasonography device. Only the right eye was evaluated in all patients. First, the eye globe was generally examined in B-mode. Then, the stiffness values of the optic nerve head, retro-orbital nerve, sclera-retina complex and retro-orbital adipose tissue in the posterior segment and the stiffness values of the cornea, lens and anterior chamber in the anterior segment of the eye were measured with SWE in kiloPascal and both groups were compared statistically.RESULTS: No statistically significant differences were found between the patient and control groups in terms of the stiffness values recorded in the measurements performed in different parts of the eye.CONCLUSIONS: Although SWE is an easily applicable method, no significant differences were found between glaucoma and control groups. However, thanks to this study, reference values for different parts of the eye in normal individuals have been determined.
SERVİKAL İNTRAEPİTELYAL LEZYONLARDA VE YÜKSEK RİSKLİ HPV TİPLERİNDE SERVİKAL KOLPOSKOPİNİN YERİ
Authors: Şentürk Metin , Tokgöz Vehbi Yavuz
Published: January 2023

AMAÇ: Bu çalışmada, smear sonucu düşük dereceli servikal intraepitelyal lezyon (LSIL), yüksek dereceli servikal intraepiteliyal lezyon (HSIL), önemi belirsiz tipik olmayan yassı hücreler (ASCUS) tespit edilen, servikal muayenede erzoyon saptanan hastalar ve yapılan human papilloma virüs (HPV) testi pozitif olan takiben kolposkopik biyopsi uygulanan hastalarımızda HPV, smear ve biyopsi sonuçları karşılaştırılması amaçlanmıştır.GEREÇ VE YÖNTEM: Toplamda çalışma grubu olarak 186 hasta dahil edildi. Hastalardan alınan servikal smearlar değerlendirildi. Servikal smear sonucu; ASCUS, LSIL ve HSIL, olan hastalar ile HPV pozitif hastalar kolposkopiye yönlendirildi. HPV tiplerinden 16, 18, 31 ve 33 olanları yüksek riskli, diğerlerini düşük riskli olarak gruplandırdık. Buna göre HPV, smear ve biyopsi sonuçları karşılaştırıldı.BULGULAR: Çalışmaya dahil edilen 186 hastanın 74’ü (%39,7) menopozdaydı. Kolposkopi yapılan hastaların 103’ünde (%55,3) HPV testi sonucu pozitif saptanması nedenli kolposkopi yapıldı. Bu hastaların 82’si yüksek riskli HPV grubundaydı. ASCUS nedenli 35 (%18,8) olguya, servikal erozyon nedenli 33 hastaya (%17,7), LSIL nedenli 12 hastaya (%6,5) HSIL nedenli 3 hastaya (%1,6) kolposkopi yapıldı. Kolposkopi yapılan hastaların alınan biyopsilerinin patoloji sonuçlarına bakacak olursak 134’ü (%72) benign olarak geldi. Smear sonucu malignite izlenmedi olarak gelen 121 hastanın kolposkopik biyopsi sonuçları değerlendirildiğinde 19 hastada CIN1 (%15,7), 6 hastada CIN2(%5), 2 hastada CIN3(%1,7) saptandı. Smear sonucuna göre LSIL gelen hastaların %25’inde ileri düzeyde epitelyal anomali (CIN 2 ve 3) gözlenirken, HSIL olan hastalarda bu oran %50 olarak tespit edilmiştir. HPV tipleri ile kolposkopik biyopsi sonuçları karşılaştırıldığında yüksek riskli HPV tipleri ile %37,8 oranında CIN 1, 2 ve 3 tespit edilirken, düşük riskli grupta bu oran %9,5 olarak bulunmuştur (p<0.016).SONUÇ: Smear tarama testi olarak kullanılmalıdır ve LSIL veya HSIL varlığında mutlaka kolposkopik biyopsi ile tanının doğrulanması gereklidir. Ayrıca özellikle yüksek riskli HPV tiplerinin pozitifliği tespit edilen olgularda smear sonucundan bağımsız olarak da kolposkopik biyopsinin önemi anlaşılmaktadır.
EVALUATION OF THE EFFICACY OF THE CLINICAL FRAILTY SCALE IN THE PREDICTION OF PROGNOSIS IN GERIATRIC PATIENTS PRESENTING TO THE EMERGENCY DEPARTMENT WITH ACUTE ABDOMINAL PATHOLOGIES: A PROSPECTIVE STUDY
Authors: Akça Hatice Şeyma , Özdemir Serdar , Algın Abdullah , Kar Evrim , Altunok İbrahim
Published: January 2023

OBJECTIVE: The CFS (Clinical Frailty Score) evaluates specific domains including function, comorbidity, and cognition to generate a frailty score ranging from 1 (very fit) to 9 (terminally ill). The aim of this study was to investigate the efficacy of CFS in the prediction of mortality in geriatric patients with acute abdominal pathologies.MATERIAL AND METHODS: Patients over 65 years who presented to the emergency department with acute abdominal pathologies between October 1, 2020 and March 31, 2021 were included in the study. Clinical Frailty Score was calculated and categorized into groups from 1 to 9. Statistical analyses were performed using SPSS version 22.0.RESULTS: The study included 151 patients, of whom 53% were female. The mean age was 75.57±8.078 years. Twenty-two (14.56%) patients died. Clinical Frailty Score was found to be statistically significantly higher in the non-survivor group (p<0.001). Eighty-three (55%) of the patients underwent surgery. There was no statistically significant relationship between Clinical Frailty Score and mortality in the operated and non-operated groups (p=0.613). We added an age of 75 and over as a criterion (Clinical Frailty Score -age) and compared its predictive ability for mortality with CFS. There was no statistically significant difference between Clinical Frailty Score and Clinical Frailty Score-age in terms of the area under the curve values in the prediction of mortality (the area under the curve Clinical Frailty Score and Clinical Frailty Score-age p=0.597, DeLong quality test).CONCLUSIONS: High Clinical Frailty Score and Clinical Frailty Score-age are generally associated with mortality, but this may occur due to non-operation, the thought that medical treatment will be sufficient, or risk information due to comorbidities. In geriatric patients, an increased Clinical Frailty Score may not be sufficient alone in making a surgery decision.
Apoyo a la promoción de la agenda de comercio para la internacionalización de agronegocios sustentables: el caso de Centroamérica
Authors: Pomareda Carlos
Published: January 2023

En Centroamérica el comercio exterior de alimentos, incluyendo el intrarregional, sigue estando sujeto a fuertes barreras, principalmente no arancelarias, tales como normas sanitarias y fitosanitarias, cuotas, licencias y otro tipo de restricciones informales que exceden ampliamente al de los aranceles. Las PYMES tienen una mayor propensión a enfrentar ese tipo de barreras en los mercados de exportación, especialmente en los sectores agrícolas, donde además de contar con escasos recursos para participar en ferias o foros de negocios internacionales, enfrentan una mayor competencia de las empresas nacionales en los países de destino. Además, tres factores ocurridos en los últimos dos años han sido de extrema importancia para los sistemas agroalimentarios y, en particular, para las pymes que participan en dichos sistemas: la pandemia de COVID-19; la crisis de los contenedores y los precios internacionales de granos, fertilizantes y el petróleo, productos de los cuales la región es sustancialmente dependiente de importaciones. Para analizar estas implicaciones, el estudio analiza cinco aspectos: el comercio agroalimentario de los países de Centroamérica, sus características y tendencias en importaciones y exportaciones; las condiciones estructurales en las principales cadenas agroalimentarias que abastecen los mercados nacionales, el mercado centroamericano y productos que exportan fuera de la región; las barreras que confrontan las pymes para participar en la agroexportación; y una propuesta de modelo para el sistema agroalimentario que permita que las pymes tengan un mejor desempeño en dicho sistema, que contribuyan más al desarrollo rural y que crezcan ganando espacio en los mercados nacionales, el mercado centroamericano y los mercados extrarregionales.
Cysticercosis of Sternocleidomastoid Muscle Presenting as Neck Swelling – A Case Report
Authors: Pilaparambil Hamza Nesva , Sureshkumar Sethulakshmi , Francis Abhilash Alex
Published: January 2023

Cysticercosis is an infection caused by Taenia Solium whose larval stage (cysticerci) can affect various human tissues. In this study, we present the case of a 32-year-old male who presented with a neck swelling of 2 months duration. High resolution ultrasonography of neck showed features suggestive of cysticercosis of sternocleidomastoid muscle. He was managed conservatively with oral albendazole 400 mg twice daily for 4 weeks. Review of the patient after 4 weeks showed complete resolution of the swelling and a repetitive ultrasonography did not show any evidence of cysticercosis. Although a rare entity and isolated cysticercosis of skeletal muscle should come into consideration among the differential diagnoses of head and neck swellings.
Refractory Coronary Vasospasm After Spine Surgery; A Rare Case Report
Authors: Salehabadi Ghazaleh , Shamsedini Ali
Published: January 2023

Refractory vasospastic angina (RVSA) is a rare condition leading to several episodes of constriction of coronary arteries which eventually leads to myocardial ischemia. Calcium-channel blockers (CCBs) and nitrates are usually used, however, sometimes the vasospasm is refractory and recurrent leading to high morbidity and mortality. A 35-year-old man known case of hypertension underwent two times operation due to T9-T10 discopathy and decompressive laminectomy of three segments T8/T9/ T10 following a previous car accident 4 months before this admission. Three days postoperatively he developed chest pain, dyspnea and diaphoresis. Electrocardiography showed inverted T wave in leads I, II and ST elevation in pericardial leads of V1-V4. Left anterior descending (LAD) artery stenosis was present (99%) at mid part that resolved after Trinitroglycerin (TNG) injection during angiography. Totally, he underwent 3 times coronary angiography due to recurrent chest pain refractory to conventional management of Prinzmetal’s angina. Coronary stent could not be placed due to severe spasm. Finally, he developed refractory chest pain and dyspnea and cardiac arrest in the CCU despite receiving intravenous high dose TNG, Diltiazem, Nicorandil and Hydrocortisone. He expired after several times of cardiopulmonary resuscitation. Refractory VSA after spine surgery has not been reported in the literature yet. This patient was resistant to available medications. There is no consensus regarding the treatment unfortunately. Randomized clinical trials have to be done to find ways regarding unconventional treatment options such as alpha-2-agonists, Corticosteroids, rho-kinase-inhibitors, statins and magnesium. Despite the fact, some surgical interventions with sympathetic denervation like left-stellate-ganglion denervation must be assessed.
Self e transgeneridade: contingências sociais e controle aversivo na identidade e vivências de transgêneros binários
Authors: Zin Gabriela de Oliveira , Gama Viviane Dutra , Reis Maria de Jesus Dutra dos
Published: January 2023

A população trans é alvo sistemático de violências e violações de direitos. As práti­cas culturais relacionadas ao gênero influenciam diretamente em como a sociedade responde negativamente a estas pessoas e no desenvolvimento do self de pessoas que não estão em conformidade com os padrões cis normativos de gênero. Desta forma, o objetivo deste artigo é trazer uma possibilidade de interpretação comportamental contextual do desenvolvimen­to das identidades de gênero trans a partir da noção de self e discutir o papel das agências de controle na perpetuação das práticas de gênero e a sua relação com a transgeneridade, especialmente a psicoterapia. Apontamos como as identidades trans são constantemente in­validadas e alguns possíveis efeitos resultantes. Buscamos, também, discutir contingências culturalmente programadas que marginalizam as pessoas trans com o objetivo de perpetuar o controle social a partir do gênero. Por fim, defendemos a análise funcional como uma das principais ferramentas dentro das terapias comportamentais para um cuidado afirmativo da identidade trans.
Metrópole do México em tempos de COVID-19
Authors: Luna Gómez Luis Alberto
Published: January 2023

A desigualdade na Cidade do México é um projeto de classe. Tem a aprovação da burocracia para especular atos de investimento, materializar temporal e espacialmente na produção imobiliária orientada à mobilidade da área metropolitana e redensificação do centro histórico, alcaldías: Cuauhtémoc, Venustiano Carranza, Miguel Hidalgo e Benito Juárez . No período da pandemia, COVID-19-19, as formas de viajar em diferentes áreas revelam duas situações: 1) nos lugares de maior queda na distribuição de renda, mobilizam-se diariamente, sem qualquer redução a pé, mototáxi e bicicleta; y, 2) O destino principal foi visitar um familiar com o transporte automatizado. A revisão foi realizada com base no levantamento de origem do destino para 2007 e 2017, nos relatórios preparados sobre mobilidade na pandemia pela empresa Apple e alguns registos do Google. Informações recentes foram extraídas da plataforma Openstreetmap e foram desenvolvidos algoritmos de densidade, isopletas de 7 km2. Bibliotecas: readxl, cartography, ggplot2, tidyverse, osm, osmdata, sf, units, spatstat e maptools incorporadas no software Rmarkdown.
Assessment of the obesity based on voice perception
Authors: Pawelec Łukasz , Kierczak Karolina , Lipowicz Anna
Published: January 2023

Human voice is an extremely important biological signal which contains information about sex, age, emotional state, health and physical features of a speaker. Estimating a physical appearance from a vocal cue can be an important asset for sciences including forensics and dietetics. Although there have been several studies focused on the relationships between vocal parameters and ratings of height, weight, age and musculature of a speaker, to our knowledge, there has not been a study examining the assessment of one’s BMI based on voice alone.
The purpose of the current study was to determine the ability of female “Judges” to evaluate speakers’ (men and women) obesity and body fat distribution from their vocal cues. It has also been checked which voice parameters are key vocal cues in this assessment.
The study material consisted of 12 adult speakers’ (6 women) voice recordings assessed by 87 “Judges” based on a 5-point graphic scale presenting body fat level and distribution (separately for men and women). For each speaker body height, weight, BMI, Visceral Fat Level (VFL, InBody 270) and acoustic parameters were measured. In addition, the accuracy of BMI category was verified. This study also aimed to determine which vocal parameters were cues for the assessment for men and women. To achieve it, two independent experiments were conducted: I: “Judges” had to choose one (obese) speaker from 3 voices (in 4 series); II: they were asked to rate body fat level of the same 12 speakers based on 5-point graphic scale.
Obese speakers (i.e., BMI above 30) were selected correctly with the accuracy greater than predicted by chance (experiment I). By using a graphic scale, our study found that speakers exhibiting higher BMI were rated as fatter (experiment II). For male speakers the most important vocal predictors of the BMI were harmonics-to-noise ratio (HNR) and formant dispersion (Df); for women: formant spacing (Pf) and intensity (loudness).
Human voice contains information about one’s increased BMI level which are hidden in some vocal cues.
Maternal risk factors associated with term low birth weight in India: A review
Authors: Vats Harsh , Saxena Ruchi , Sachdeva Mohinder P. , Walia Gagandeep K. , Gupta Vipin
Published: January 2023

Low birth weight is one of the leading factors for infant morbidity and mortality. To a large extent affect, various maternal risk factors are associated with pregnancy outcomes by increasing odds of delivering an infant with low birth weight. Despite this association, understanding the maternal risk factors affecting term low birth weight has been a challenging task. To date, limited studies have been conducted in India that exert independent magnitude of these effects on term low birth weight. The aim of this review is to examine the current knowledge of maternal risk factors that contribute to term low birth weight in the Indian population. In order to identify the potentially relevant articles, an extensive literature search was conducted using PubMed, Goggle Scholar and IndMed databases (1993 – Dec 2020). Our results indi­cate that maternal age, educational status, socio-economic status, ethnicity, parity, pre-pregnancy weight, maternal stature, maternal body mass index, obstetric history, maternal anaemia, gestational weight gain, short pregnancy outcome, hypertension during pregnancy, infection, antepartum haemorrhage, tobacco consumption, maternal occupation, maternal psychological stress, alcohol consumption, antenatal care and mid-upper arm circumference have all independent effects on term low birth weight in the Indian pop­ulation. Further, we argue that exploration for various other dimensions of maternal factors and underlying pathways can be useful for a better understanding of how it exerts independent association on term low birth weight in the Indian sub-continent.