bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors Affecting Students’ Use of Mobile Banking: An Extension of Technology Acceptance Model
Authors: Susilowati Endah , Auliah Alfiah Nur
Published: August 2024

Current developments in technology and communications have created various types and new business opportunities, so it is very important for companies to carefully understand customer needs, discover people's desires, and be able to provide products or services to customers that meet people's demands or exceed people's expectations. This study aims to test and prove the factors that influence the use of mobile banking, which consists of the quality of information systems, trust, capability of individual operations, user attitudes, and intention to use. This study assesses the technology acceptance model (TAM) theory to develop variable relationships. The study population was active students of a university in East Java, and the sample was taken by purposive sampling with a total sample of 91 students. This research uses a quantitative approach and questionnaire data collection methods. Data analysis techniques using multiple linear analysis with SPSS 23 software. The results of this study indicate that trust, individual capability to operate, and intention to use affect mobile banking use. In contrast, the quality of information systems and user attitudes do not affect the use of mobile banking. This study suggests that mobile banking providers must maintain consumers’ trust, capability to operate, and attitude so that the use of mobile banking is increased.
PENGARUH EARNING PER SHARE (EPS) DAN RETURN ON EQUITY (ROE) TERHADAP HARGA SAHAM PADA SEKTOR PERBANKAN BUMN YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2016-2022
Authors: Indah Sri
Published: August 2024

Good company value is very useful because it is able to attract investor interest in the company, showing the company's ability to generate profits and increase share prices so that it can support shareholder profitability. The aim of this research is to determine the effect of Earning Per Share (eps) and Return on Equity (roe) on share prices in the state-owned banking sector listed on the Indonesian stock exchange for the 2016-2022 period. The research carried out was research using quantitative methods. The research carried out by researchers relates to numbers and calculations will be carried out from the data that has been obtained by downloading financial reports on the official website of the Indonesian Stock Exchange (BEI) with an observation period from 2016 to 2022. The data collection technique used by researchers is a documentation technique. The data analysis technique in this research uses Descriptive Data Analysis, Multiple Linear Regression Test. The results of this research show that the Earning Per Share (EPS) variable partially has a positive effect on the stock price variable and has a significant effect on the stock price variable, while the Earning Per Share (EPS) and Return on Equity (ROE) variables simultaneously have an effect on the stock price variable.
PENGARUH CITRA MERK, KUALITAS PRODUK, PRODUCT KNOWLEDGE TERHADAP REPURCHASE INTENSION PADA GONGSO KOPI
Authors: Ilham Hadzafi Aldo , Arifin Samsul
Published: August 2024

This study was used to explore the influence of brand image, product quality, and product knowledge on repurchase intentions at Gongso Kopi. This research uses quantitative data in the form of numbers (numerics). This data was obtained from primary and secondary sources. Consumers who buy drinks and food at Gongso Kopi Jepara are the population in this research. Sample determination was carried out using the Purposive Sampling technique (samples were selected based on certain criteria). Data collection in this study was carried out by distributing questionnaires which were equipped with a Likert scale as a measuring tool. The data analysis technique uses a multiple regression analysis approach. Through the process of analyzing data, researchers found that the brand image variable had a positive and significant influence on repurchase intentions at Gongso Kopi. The product quality variable also has a positive and significant influence on repurchase intentions at Gongso Kopi. Apart from that, the product knowledge variable also has a positive and significant effect on repurchase intentions at Gongso Kopi.
ANALISIS FAKTOR MAKRO DAN MIKRO EKONOMI TERHADAP HARGA SAHAM PERUSAHAAN PERBANKAN DIGITAL
Authors: Panca Fatikhul Inami  , Muttaqiin Ninnasi
Published: August 2024

This research aims to determine the influence of macro and micro economic factors on share price fluctuations in digital banking sector companies listed on the Indonesian Stock Exchange (BEI) during the 2020-2023 period. Share prices in this study are used as the dependent variable. Meanwhile, the independent variables used in this research are inflation, interest rates, exchange rates, GDP, broad money supply, EPS, PER, BVPS, ROA, ROE, company size, capital structure, and CR. The data management method used is multiple linear regression analysis. The findings show that simultaneously, the variables inflation, interest rates, exchange rates, GDP, broad money supply, EPS, PER, BVPS, ROA, ROE, company size, capital structure and CR significantly affect stock prices. The variables interest rate, broad money supply, PER, BVPS, and CR partially have a significant effect on stock prices. Meanwhile, the variables inflation, exchange rate, GDP, EPS, ROA, ROE, company size and capital structure partially do not have a significant effect on stock prices.
Zastosowanie wielowymiarowych metod statystycznych w diagnozie alfabetyzmu finansowego w Polsce na podstawie testu „wielkiej piątki”
Authors: Brzezińska Justyna
Published: August 2024

Wiedza finansowa (ang. financial knowledge) i umiejętność jej zastosowania w praktyce (ang. financial skills, abilities) określają alfabetyzm finansowy (ang. financial literacy). Jak wynika z ostatnich badań, poziom wiedzy finansowej Polaków jest niski na tle zarówno Europy, jak i krajów świata. Stąd też istotna wydaje się potrzeba uporządkowania i usystematyzowania wiedzy w tym obszarze. Ponadto, brakuje rzetelnych narzędzi statystycznych, które pozwalałyby na diagnozę poziomu alfabetyzmu finansowego, dostarczając obiektywnych wyników, a także umożliwiając wdrożenie rozwiązań, których celem byłaby poprawa wiedzy oraz świadomości finansowej. W niniejszym artykule zostaną przedstawione wyniki badań opartych na teście wiedzy finansowej i pytaniach zawartych w kwestionariuszu „wielkiej piątki” (ang. big five), które przeprowadzono w Polsce. Zgromadzone w tym celu dane opracowano z wykorzystaniem wielowymiarowych metod statystycznych przeznaczonych do analizy pozycji testowych i danych jakościowych, a wszelkie obliczenia zostały przeprowadzone w programie R.
Propozycja uniwersalnego rejestru i listy ryzyk w projektach kulturalnych
Authors: Krawczyńska Alicja , Kuchta Dorota , Klaus-Rosińska Agata
Published: August 2024

Projekty realizowane przez publiczne instytucje kultury to najczęściej wydarzenia, których celem jest edukacja kulturowa odbiorców. Charakteryzują się one określonym terminem i budżetem oraz udziałem artystów i partnerów. Dlatego wymagają zastosowania adekwatnych metod zarządzania, w tym zarządzania ryzykiem, jako jednego z czynników ich pomyślnej realizacji. Analiza literatury pokazuje, że istnieje niewiele badań na ten temat. Dopasowana do projektów kulturalnych metoda zarządzania ryzykiem z wykorzystaniem podejścia scrum była przedmiotem badań jednej z autorek tekstu. Polegały one na wdrożeniu autorskiego modelu zarządzania w pięciu instytucjach kultury, a następnie zastosowaniu go w wybranych projektach. Podczas realizacji projektów członkowie zespołów identyfikowali ryzyka związane z zadaniami w tych projektach. Na podstawie wyników badań, najnowszej literatury dotyczącej zarządzania ryzykiem oraz dokumentów wewnętrznych autorki opracowały zarówno adekwatną dla instytucji kultury strukturę rejestru ryzyka, opartą na metodzie ATOM, jak i uniwersalną listę ryzyk towarzyszących projektom kulturalnym.
Interesariusze dostępnej przestrzeni publicznej na przykładzie warszawskiego Ursynowa
Authors: Sadowy Katarzyna , Zajc Danuta
Published: August 2024

Celem artykułu jest ocena dostosowania przestrzeni publicznych do potrzeb osób ze szczególnymi potrzebami przez określone podmioty i instytucje odpowiedzialne za tego typu działania na przykładzie wybranego studium przypadku (Dzielnicy Ursynów m.st. Warszawy). Analizą objęto takie usługiużyteczności publicznej jak: biblioteki, domy kultury, urząd dzielnicy, transport publiczny, kościoły oraz przestrzenie otwarte, łączące wybrane funkcje. Celami szczegółowymi prezentowanego studium są: ocena różnic występujących między właścicielami/zarządcami przestrzeni, wskazanie lidera, którego działania mogą wpływać na ogólną jakość przestrzeni, oraz identyfikacja barier i dobrych praktyk. W artykule wykorzystano materiał z badań terenowych, obserwacji uczestniczącej przeprowadzonej w okresie marzec–maj 2022 r. oraz w listopadzie 2023 r. i studiów literatury, zrealizowanych z uwzględnieniem ogólnodostępnych baz danych i informacji publicznych. Na postawie dostępnych danych zidentyfikowano bariery i dobre praktyki. Liderem tworzącym tak formalne, jak nieformalne standardy (dobre wzorce) postępowania jest samorząd terytorialny, na poziomie miejskim i dzielnicowym. Przeszkody utrudniające rozpowszechnianie właściwych rozwiązań to: niewystarczająca współpraca między interesariuszami – zarówno wewnątrz struktur samorządowych, jak i międzysektorowa, konflikty interesów wśród użytkowników przestrzeni oraz potrzeba znacznych nakładów finansowych. Niedostateczna świadomość części indywidualnych użytkowników przestrzeni skutkuje zachowaniami obniżającymi jej dostępność.
New ideals of Bloch mappings which are I-factorizable and Möbius-invariant
Authors: Jiménez Vargas Antonio , Ruiz Casternado David
Published: August 2024

In this paper, we introduce an unified method for generating ideals of Möbius-invariant Banach-valued Bloch mappings on the complex open unit disc $\D$, through the composition with the members of a Banach operator ideal $\I$. Using linearisation of derivatives of Banach-valued normalized Bloch mappings on $\D$, this composition method yields the so-called ideals of $\I$-factorizable normalized Bloch mappings $\I\circ\hat{\B}$, where $\hat{\B}$ denotes the class of normalized Bloch mappings on $\D$. We present new examples of them as ideals of separable (Rosenthal, Asplund) normalized Bloch mappings and $p$-integral (strictly $p$-integral, $p$-nuclear) normalized Bloch mappings for any $p\in[1,\infty)$. Moreover, the Bloch dual ideal $\I^{\hat{\B}\text{-}\d}$ of an operator ideal $\I$ is introduced and shown that it coincides with the composition ideal $\I^\d\circ\hat{\B}$.
Internal factors influencing bid/no bid decision for contractors on construction projects: The case in Hanoi
Authors: Tran Manh Linh , Ha Son Tung , Tran Thi Hong Viet , Le Van Nam
Published: August 2024

Purpose - A pre-bid screening and analysis procedure can save company resources and reduce overall costs. Bidding construction projects is considered a vital decision for contractors. The objective of this paper is to identify and rank the internal factors influencing the bidding decision from the perspective of local contractors operating in Hanoi, Vietnam.
Design/methodology/approach - This study was investigated through a questionnaire, which included a randomly selected sample of 196 contractors in the construction industry in Hanoi. The questionnaire was structured based on relevant literature influencing the bidders’ decision. Cronbach’s Alpha, EFA, Relative important index (RII), and Binary Logistics Regression model are used to explore the impact of each independent variable.
Findings - Three internal factors, including Contractor Related (CR), Contractor Benefit (CB) and contractor’s previous experience (CE), facilitate the bidding decision for construction projects of contractors. The study also ranks the importance of each criterion, and the 5 criteria considered most important are “past profit in a similar job,” “previous relationship and communication level with the clients,” “need for wor,” “reliability of subcontractors,” “management or technical expertise from past similar jobs”.
Implication - Investors and contractors need to pay attention to profits from similar projects in the past, relationships with investors, or job needs to improve contractors’ decision-making and hone their competitiveness in project bidding.
Originality/value - This study is among the first to examine this research topic in the context of Vietnam. The research also helps improve the theoretical basis of factors affecting bidding participation and assists investors and contractors in building effective bidding strategies.
Fennistiikan opinnäytteitä III
Authors: Haakana Markku , Harmanen Minna , Leino Pentti , Mäntynen Anne
Published: August 2024

Bibliografian käyttäjälle

Tämä bibliografia on jatkoa aiemmin ilmestyneille fennistiikan opinnäytebibliografioille (Fennistiikan opinnäytteitä ja Fennistiikan opinnäytteitä II), jotka ovat ilmestyneet tässä samassa sarjassa vuosina 1977 ja 1984. Bibliografia on pääosin edeltäjiensä kaltainen; nyt mukaan on otettu myös Helsingin Kauppakorkeakoulussa ja Vaasan yliopistossa suomen kielestä tehdyt opinnäytteet.

Luettelossa esitetään kustakin opinnäytteestä seuraavat tiedot: tekijän suku- ja etunimi, työn nimi, opinnäytteen aste, ilmestymisvuosi, sivumäärä, liitteiden ja karttojen määrä ja korkeakoulu, jossa työ on tarkastettu. Tiedot eivät kaikilta osin ole täydellisiä senkään takia, että niitä on kerätty eri korkeakouluista useaan otteeseen ja ne ovat kulkeneet monen käden kautta. Toivottavasti kovin pahoja virheitä ei kuitenkaan ole jäänyt lopulliseen versioon.

Asiahakemisto on entisenlainen, vain kielentutkimuksen alueisiin on lisätty muutama uusi tutkimussuuntaus. Luokitus ei tietenkään ole aukoton, koska se on enimmäkseen tehty tutkielmien nimien perusteella. Esimerkiksi kielenhuollon kohdalta ei välttämättä löydy ylioppilasaineiden oikeakielisyyttä tarkastelevaa tutkielmaa, ellei näkökulma käy tutkielman nimestä ilmi. Asiahakemiston käytön helpottamiseksi on kirjan lopussa luettelo hakusanoista, joiden avulla kätevimmin pääsee etsimänsä jäljille. Toivottavasti bibliografia puutteineenkin palvelee sitä tarvitsevia, sekä tutkijoita, opettajia että opiskelijoita.

Bibliografian tekemiseen on osallistunut useita ihmisiä. Varsinaisen työn aloitti Markku Haakana, joka kokosi luettelon ja aloitti luokittelun. Pentti Leino tarkasti asiahakemiston luokittelun. Tiina Lappalainen puolestaan muokkasi bibliografian tekstiasua. Kiitokset hänelle siitä. Bibliografian loppuunsaattaminen ja luokittelun täydentäminen jäi Minna Harmasen ja Anne Mäntysen tehtäväksi. Tässä vaiheessa bibliografiaan päätettiin lisätä vielä vuoden 1992 opinnäytteet sekä Helsingin Kauppakorkeakoulussa tehdyt opinnäytteet.

Lopuksi kiitämme kaikkia, jotka ovat kärsivällisesti toimittaneet pyydettyjä tietoja bibliografiaa varten ja tarkastaneet sen eri versioita.

Helsingissä 10. kesäkuuta 1993

Markku Haakana
Minna Harmanen
Anne Mäntynen
Suomalais-unkarilaisten kulttuurisuhteiden bibliografia vuoteen 1981
Authors: Tervonen Viljo , Wichmann Irene
Published: August 2024

Esipuhe

Suomen ja Unkarin väliset kulttuurisuhteet ovat monessa mielessä ainoalaatuiset. Erityisen merkillepantavaa on, että verraten etäällä toisistaan asuvien kansojen kesken ovat kulttuuriyhteydet jatkuneet jo lähes puolentoista vuosisadan ajan. Niiden pohjana on tieto kielten sukulaisuudesta; tunne läheisyydestä on vuosikymmenten mittaan jatkuvasti voimistunut ja levinnyt entistä laajempiin kansankerroksiin. Tiiviiden kulttuurisuhteiden kehittyessä on monilla aloilla ehtinyt muodostua traditioita, jotka ovat johtaneet yhä uusiin kosketuksiin.

Suomalais-unkarilainen sekakomitea päätti kokouksessaan kesällä 1980 ryhtyä laatimaan Suomen ja Unkarin välisten kulttuurisuhteiden historiaa ja toteuttaa näin jo pari vuotta aikaisemmin lausutun ajatuksen. Tämä hanke sisällytettiin myös Suomen ja Unkarin kulttuurivaihtoa vuosina 1980-1983 koskevaan työsuunnitelmaan.

Kulttuurisuhteiden historia laaditaan molempien osapuolten yhteistyönä, kirjoittajina parikymmentä suomalaista ja unkarilaista tiedemiestä ja kulttuurisuhteiden historian tuntijaa. Pyrkimyksenä on saada aikaan tieteellisesti pätevä, kansantajuisesti kirjoitettu esitys, josta yhteistyön olennaiset piirteet selviävät. Teos julkaistaan Suomen ja Unkarin välisen kulttuurisopimuksen 25-vuotisjuhliin mennessä vuonna 1984 sekä suomen että unkarin kielellä. Tutkitaan myös mahdollisuuksia teoksen julkaisemiseksi suurilla sivistyskielillä. Erikoislaatuisuutensa vuoksi suomalais-unkarilaiset kulttuurisuhteet saattavat olla, elleivät suorastaan malliksi, niin kuitenkin innostavia ja herätteitä antavia kansojen väliselle vuorovaikutukselle.

Tämän historiatyön pohjaksi ryhdyttiin kummassakin maassa keräämään aineistoa sekä päätettiin laatia aihetta valaisevat mahdollisimman täydelliset bibliografiat.

Tarkoituksena on, että bibliografiasta toimitetaan edellä mainitun historiatyön valmistumisen jälkeen laajempi laitos, jossa työn aikana esiin tuleva materiaali voidaan ottaa huomioon. Historiatyötä varten asetettu työryhmä on kuitenkin pitänyt tarpeellisena saattaa bibliografian ensimmäinen laitos jo tässä vaiheessa julkisuuteen, jotta se voi heti olla sekä tämän historiatyön että Suomen ja Unkarin suhteita valaisevan muun tutkimustyön ja jatkuvan kulttuurivuorovaikutuksen apuna.

Opetusministeriön ja Suomalais-unkarilaisen sekakomitean Suomen alakomitean puolesta lausun kiitokset Irene Wichmannille ja Viljo Tervoselle hyvin tehdystä ja nopeasti valmistuneesta työstä sekä edelleen kiitokset Helsingin yliopiston suomen kielen laitokselle, joka on ystävällisesti ottanut bibliografian toimitteisiinsa.

Jaakko Numminen
Suomen alakomitean puheenjohtaja
Kaukomailta ja työkammioista
Authors: Joki Aulis J. , Tanner Satu , Peräniitty Anneli
Published: August 2024

(Ei abstraktia tai tällaiseksi katsottavaa esipuhetta)
Development and validation of UV-spectrophotometry method for quantitative determination of amorphous darunavir
Authors: Mandrik M. A. , Sadkovskii I. A. , Pinegina E. D. , Korol L. A. , Krasnuk I. I.
Published: August 2024

Introduction. Darunavir as an effective antiretroviral drug is widely used in clinical practice, including for the treatment of pediatric patients, as well as pregnant women, and for personalized therapy. Currently darunavir is used in the production of finished dosage forms, both in the form of crystalline ethanolate and in the form of an amorphous substance. In this regard, there is a need to develop and improve methods for the quantitative determination of darunavir. As an inexpensive and effective alternative to common chromatographic and titrimetric methods, spectrophotometric determination of darunavir in the ultraviolet region of the spectrum (UV spectrophotometry) may be used.

Aim. To develop and validate a method for the quantitative determination of amorphous darunavir in the substance by UV spectrophotometry.

Materials and methods. The following substances and consumables were used for the research: powdered amorphous darunavir substance (USP); darunavir reference standard (MSN Pharmachem Pvt. Ltd., India); methanol for HPLC Gradient Grade 99.9 % (High purity); acetonitrile for HPLC Gradient Grade 99.9 %; glacial acetic acid for HPLC; 0.1 M perchloric acid solution (in anhydrous acetic acid) for titration in non-aqueous media; nylon syringe filters with a pore diameter of 0.22 microns. Spectrophotometric determination of darunavir was carried out using an Cary 60 spectrophotometer (Agilent Technologies, USA) and a UNICO 2800 spectrophotometer (United Products & Instruments, Inc., USA). To prepare standard solutions, we used analytical balance Analytical Balance MS105/A (METTLER TOLEDO, Switzerland), analytical balance GH-120 (AND, Japan) class A measuring glassware, graduated pipettes ISOLAB.

Results and discussion. The method was developed and validated for the following characteristics: specificity, linearity, accuracy, precision, analytical range. According to the study results, the main validation characteristics of the method meet the acceptance criteria.

Conclusion. A new method for the quantitative determination of amorphous darunavir by UV spectrophotometry was successfully developed and validated. The method may be used to control the quality of substances of amorphous darunavir, including the intrapharmaceutical control.
Theoretical Issues in DSGE Modelling
Authors: Abidemi Abdulsalam , Abubakar Jamaladeen , Abdusalam Nafiu
Published: August 2024

The paper examines the theoretical issues in DSGE Models. Reviewing relevant literature, it was observed that DSGE models are based on micro-founded and real business cycle models with theories of nominal frictions. The paper concludes that much of the development of the model in literature and policy circles, including central banks, focuses on the responses of macroeconomic variables to shocks and forecasting. Finally, the paper recommends the need to advance the DSGE model to capture movements in medium-term shocks and dynamics related to parameters like socio-economic, output, and unconventional monetary policies. These modifications would make the DSGE model more suitable for addressing the key issues confronting policymakers.
External Shocks and Business Cycles in Nigeria: Accounting for the Roles of Domestic Oil-Refining Alternative and Oil Price Fiscal Rule
Authors: Olaolu Olayeni
Published: August 2024

The paper investigates the role of oil price fiscal rule (OPFR), and functional domestic oil refineries in curtailing the effects of external shocks on the Nigerian economy. A dynamic stochastic general equilibrium (DSGE) model is developed, calibrated and estimated using Random Walk Metropolis sampling method. The model is estimated under the benchmark, OPFR-only, and refinery-only scenarios. The results reveal that building or revamping domestic oil refineries may help the economy to withstand long term shock, but in the short run, the OPFR clearly emerges as the most potent. The non-oil external shocks are not significant under the three scenarios. However, oil-related external shocks have significant implications for business cycles in Nigeria, reinforcing the demand- and supply-side shocks. Furthermore, it is found that there is a need for functional domestic oil refineries in insulating the economy against external shocks, however, there is a huge welfare loss associated with refinery development alone. Thus, policymakers should consider instituting the OPFR to stem external shocks in the short run, while building oil refineries to tackle external shocks in the long run.
Pengembangan Media Pembelajaran Powerpoint Interaktif Berbantuan Canva Pada Pembelajaran Tematik Sekolah Dasar
Authors: Aisyah Azizatullatifah , Trisniawati  , Nelly Rhosyida
Published: August 2024

Tujuan penelitian ini adalah mengembangkan dan mendeskripsikan media pembelajaran PowerPoint interaktif berbantuan Canva pada pembelajaran Tematik Tema 5 subtema 2 Pembelajaran 6 pada peserta didik kelas II Sekolah Dasar. Pengumpulan data menggunakan wawancara dengan guru kelas dan kuesioner yang diberikan oleh guru yang dilaksanakan pada tanggal 21 Februari 2023. Penelitian ini dilakukan di salah satu SD negeri di Yogyakarta. Penelitian dan pengembangan ini mengadopsi model ADDIE dengan langkah analysis, design, development, implementation dan evaluation. Instrumen penelitian berupa kuesioner ahli media terdiri dari 8 indikator, kuesioner untuk ahli materi berjumlah 11 indikator dan juga 10 butir pedoman wawancara untuk guru. Validator terdiri dari ahli media dan ahli materi. Hasil validasi instrumen dihitung menggunakan skala Likert, kemudian hasil skor dihitung persentasenya. Dalam penelitian ini, ditemukan bahwa (1) mengembangkan media pembelajaran PowerPoint interaktif berbantuan Canva pada pembelajaran Tematik Tema 5 subtema 2 Pembelajaran 6 pada peserta didik kelas II Sekolah Dasar berbantuan Canva. (2) Mendeskripsikan hasil dari pengembangan media pembelaajran (3) Media direvisi sesuai dengan saran dan komentar dari ahli media. Hasil validasi di peroleh rata-rata skor 97,65% hal tersebut membuktikan bahwa media pembelajaran PowerPoint Interaktif dengan bantuan Canva memiliki tingkat validitas yang tinggi, sehingga dapat menjadi alternatif media pembelajaran di kelas II sekolah dasar.
Hubungan Indeks Prestasi Kumulatif (IPK) dan Lama Studi Mahasiswa Program Studi Pendidikan Matematika
Authors: Medika Gema Hista , Tomi Zebbil Billian , Mustika Helma
Published: August 2024

Penelitian ini bertujuan untuk mengetahui hubungan Indeks Prestasi Kumulatif (IPK) dan lama studi mahasiswa Program studi pendidikan matematika UIN Bukittinggi. Penelitian ini termasuk penelitian korelasional dengan pendekatan kuantitatif. Populasi penelitian ini adalah wisudawan/ti angkatan I, II dan III Program studi pendidikan matematika UIN Bukittinggi berjumlah 120 orang. Ukuran sampel penelitian sebanyak 30 orang ditentukan dengan teknik stratified random sampling. Data pada penelitian ini berupa nilai Indeks Prestasi Kumulatif (IPK) dengan lama studi wisudawan/ti angkatan I, II dan III Program studi pendidikan matematika UIN Bukittinggi. Dengan menggunakan analisis korelasi product momen diperoleh nilai signifikan antara Indeks Prestasi Kumulatif (IPK) dengan lama studi yaitu -0,429  dimana r = -0,429 dan diperoleh nilai signifikansi sebesar 0,018. Hasil penelitian menunjukkan bahwa terdapat hubungan yang signifikan dengan kategori sedang antara Indeks Prestasi Kumulatif (IPK) dengan lama studi mahasiswa program studi pendidikan matematika UIN Bukittinggi. Temuan ini dapat dijadikan sebagai referensi oleh program studi dalam merumuskan program layanan kemahasiswaan yang sesuai dan kegiatan konsultasi mahasiwa dengan penasihat akademik.
Intertextualidade e Performance nas “Três Sátiras para Piano” de José Alberto Kaplan
Authors: Lima Tassio , Holanda Joana
Published: August 2024

Este estudo propõe analisar as Três Sátiras para Piano de José Alberto Kaplan à luz da intertextualidade. A discussão é norteada por autores como Klein (2005), Kaplan (2006), Fonseca (2005) Gomes (1985) e Hatten (1985). Os objetivos da investigação consistem em compreender as múltiplas referências de contrastes estilísticos e estéticos utilizadas pelo compositor e explorar as conexões entre tais elementos. Além disso, a investigação visa contribuir para o aprimoramento de aspectos interpretativos associados a partir da análise das referências intertextuais. Através de uma abordagem analítico-comparativa, são examinados aspectos musicais heterogêneos que conferem peculiaridade às suas obras. Ao estabelecer essas interrelações, o trabalho contribui para a elaboração da performance e para a compreensão da obra.
Tuberculosis survivors and the risk of cardiovascular disease: analysis using a nationwide survey in Korea
Authors: Yang Jiyoul , Kim Sun-Hyung , Sim Jae Kyeom , Gu Seonhye , Seok Jeong Won , Bae Dae-Hwan , Cho Jun Yeun , Lee Ki Man , Choe Kang Hyeon , Lee Hyun , Yang Bumhee , Min Kyung Hoon
Published: August 2024

Background

Although the association between tuberculosis (TB) and cardiovascular disease (CVD) has been reported in several studies and is explained by mechanisms related to chronic inflammation, few studies have comprehensively evaluated the association between TB and CVD in Korea.

Methods

Using the Korea National Health and Nutrition Survey, we classified individuals according to the presence or absence of previous pulmonary TB was defined as the formal reading of a chest radiograph or a previous diagnosis of pulmonary TB by a physician. Using multivariable logistic regression analyses, we evaluated the association between the 10-year atherosclerotic cardiovascular disorder (ASCVD) risk and TB exposure, as well as the 10-year ASCVD risk according to epidemiological characteristics.

Results

Among the 69,331 participants, 4% (n = 3,101) had post-TB survivor group. Comparing the 10-year ASCVD risk between the post-TB survivor and control groups, the post-TB survivor group had an increased 10-year ASCVD risk in the high-risk group (40.46% vs. 24.00%, P < 0.001). Compared to the control group, the intermediate- and high-risk groups had also significantly increased 10-year ASCVD risks (odds ratio [OR] 1.14, 95% confidence interval [CI] 1.04–1.23 and OR 1.69, 95% CI 1.59–1.78, respectively) in the post-TB survivor group. In the association of CVD among post-TB survivors according to epidemiologic characteristics, age [adjusted OR (aOR) 1.10, 95% CI 1.07–1.12], current smoking (aOR 2.63, 95% CI 1.34–5.14), a high family income (aOR 2.48, 95% CI 1.33–4.62), diabetes mellitus (aOR 1.97, 95% CI 1.23–3.14), and depression (aOR 2.06, 95% CI 1.03–4.10) were associated with CVD in the post-TB survivor group.

Conclusions

Our study findings suggest a higher 10-year ASCVD risk among TB survivors than healthy participants. This warrants long-term cardiovascular monitoring and management of the post-TB population.
T1 mapping combined with arterial spin labeling MRI to identify renal injury in patients with liver cirrhosis
Authors: Xie Shuangshuang , Chen Mengyao , Chen Chiyi , Zhao Yumeng , Qin Jiaming , Qiu Caixin , Zhu Jinxia , Nickel Marcel Dominik , Kuehn Bernd , Shen Wen
Published: August 2024

Purpose

We investigated the capability and imaging criteria of T1 mapping and arterial spin labeling (ASL) MRI to identify renal injury in patients with liver cirrhosis.

Methods

We recruited 27 patients with cirrhosis and normal renal function (cirrhosis-NR), 10 with cirrhosis and renal dysfunction (cirrhosis-RD) and 23 normal controls (NCs). All participants were examined via renal T1 mapping and ASL imaging. Renal blood flow (RBF) derived from ASL was measured from the renal cortex, and T1 values were measured from the renal parenchyma (cortex and medulla). MRI parameters were compared between groups. Diagnostic performances for detecting renal impairment were statistically analyzed.

Results

Cortical T1 (cT1) and medullary T1 (mT1) were significantly lower in the NCs than in the cirrhosis-NR group. The cortical RBF showed no significant changes between the NCs and cirrhosis-NR group but was markedly decreased in the cirrhosis-RD group. The areas under the curve (AUCs) for discriminating cirrhosis-NR from NCs were 0.883 and 0.826 by cT1 and mT1, respectively. Cortical RBF identified cirrhosis-RD with AUC of 0.978, and correlated with serum creatinine (r = −0.334) and the estimated glomerular filtration rate (r = 0.483). A classification and regression tree based on cortical RBF and cT1 achieved 85% accuracy in detecting renal impairment in the cirrhosis.

Conclusion

Renal T1 values might be sensitive predictors of early renal impairment in patients with cirrhosis-NR. RBF enabled quantifying renal perfusion impairment in patients with cirrhosis-RD. The diagnostic algorithm based on cortical RBF and T1 values allowed detecting renal injury during cirrhosis.
Identification of candidate SNPs associated with embryo mortality and fertility traits in lactating Holstein cows
Authors: Gonzalez Berrios Carolina L. , Bowden Courtney F. , Saad Hamad M. , Bishop Jeanette V. , Van Campen Hana , Pinedo Pablo , Hansen Thomas R. , Thomas Milton G.
Published: August 2024

Introduction: Targeted single nucleotide polymorphisms (SNPs) have been used in genomic prediction methodologies to enhance the accuracy of associated genetic transmitting abilities in Holstein cows. The objective of this study was to identify and validate SNPs associated with fertility traits impacting early embryo mortality.

Methods: The mRNA sequencing data from day 16 normal (n = 9) and embryo mortality (n = 6) conceptuses from lactating multiparous Holstein cows were used to detect SNPs. The selection of specific genes with SNPs as preliminary candidates was based on associations with reproductive and fertility traits. Validation of candidate SNPs and genotype-to-phenotype analyses were conducted in a separate cohort of lactating primiparous Holstein cows (n = 500). After genotyping, candidate SNPs were filtered using a quality control pipeline via PLINK software. Continuous numeric and binary models from reproductive traits were evaluated using the mixed procedure for a generalized linear model-one way ANOVA or logistic regression, respectively.

Results: Sixty-nine candidate SNPs were initially identified, but only 23 passed quality control procedures. Ultimately, the study incorporated 466 observations for statistical analysis after excluding animals with missing genotypes or phenotypes. Significant (p <0.05) associations with fertility traits were identified in seven of the 23 SNPs: DSC2 (cows with the A allele were older at first calving); SREBF1 and UBD (cows with the T or G alleles took longer to conceive); DECR1 and FASN (cows with the C allele were less likely to become pregnant at first artificial insemination); SREBF1 and BOLA-DMB (cows with the T allele were less likely to be pregnant at 150 days in milk). It was also determined that two candidate SNPs within the DSC2 gene were tag SNPs. Only DSC2 SNPs had an important allele substitution effect in cows with the G allele, which had a decreased age at first calving by 10 days.

Discussion: Candidate SNPs found in this study could be used to develop genetic selection tools to improve fertility traits in dairy production systems.
Nonalcoholic or metabolic-associated fatty liver disease and colorectal polyps: evidence from meta-analysis and two-sample Mendelian randomization
Authors: Zhai Dong , Xu Sumei , Liu Haoge , Tong Xiaojuan
Published: August 2024

Introduction

Nonalcoholic or metabolism-associated fatty liver disease (NAFLD or MAFLD) and colorectal polyps are chronic conditions strongly linked to lifestyle factors. However, the precise causal link between NAFLD or MAFLD and the development of colorectal polyps is not yet fully understood. This study aimed to evaluate the association between NAFLD or MAFLD and the risk of colorectal polyps based on a meta-analysis and two-sample Mendelian randomization (MR) analyses.

Methods

PubMed, Embase, Cochrane Library databases were searched for eligible studies to be included in the meta-analysis. We conducted a thorough search of the PubMed, Embase, and Cochrane Library databases to identify eligible studies prior to 22 March 2024. Subgroup analyses were performed based on sex, age, and geographical region. Causality between NAFLD/MAFLD and colorectal polyps was explored by using two-sample Mendelian randomization (MR) analyses.

Results

Based on an analysis of 17 studies encompassed within this meta-analysis, a significant correlation was identified between the presence of NAFLD/MAFLD and elevated incidence of colorectal polyps (NAFLD: OR = 1.57, 95% CI: 1.43–1.73, I2 = 38%, p = 0.06; MAFLD: OR = 1.67, 95% CI: 1.40–2.00, I2 = 77%, p = 0.002). However, current evidence does not support a causal relationship between NAFLD/MAFLD and the prevalence of colorectal polyps (OR = 0.9998315, 95% CI: 0.9987566–1.000907, P = 0.7587638).

Conclusion

NAFLD/MAFLD demonstrated a significant positive correlation with an elevated risk of developing colorectal polyps. However, the MR analysis suggested that no causal relationship existed between NAFLD/MAFLD and colorectal polyps. Therefore, further research is required to identify the underlying mechanism of causal link between these diseases.
Vaccine and antiviral drug promise for preventing post-acute sequelae of COVID-19, and their combination for its treatment
Authors: Sumi Tomonari , Harada Kouji
Published: August 2024

Introduction

Most healthy individuals recover from acute SARS-CoV-2 infection, whereas a remarkable number continues to suffer from unexplained symptoms, known as Long COVID or post-acute COVID-19 syndrome (PACS). It is therefore imperative that methods for preventing and treating the onset of PASC be investigated with the utmost urgency.

Methods

A mathematical model of the immune response to vaccination and viral infection with SARS-CoV-2, incorporating immune memory cells, was developed.

Results and discussion

Similar to our previous model, persistent infection was observed by the residual virus in the host, implying the possibility of chronic inflammation and delayed recovery from tissue injury. Pre-infectious vaccination and antiviral medication administered during onset can reduce the acute viral load; however, they show no beneficial effects in preventing persistent infection. Therefore, the impact of these treatments on the PASC, which has been clinically observed, is mainly attributed to their role in preventing severe tissue damage caused by acute viral infections. For PASC patients with persistent infection, vaccination was observed to cause an immediate rapid increase in viral load, followed by a temporary decrease over approximately one year. The former was effectively suppressed by the coadministration of antiviral medications, indicating that this combination is a promising treatment for PASC.
Effects of a phytobiotic-based additive on the growth, hepatopancreas health, intestinal microbiota, and Vibrio parahaemolyticus resistance of Pacific white shrimp, Litopenaeus vannamei
Authors: Ma Qiang , Zhao Guiping , Liu Jiahao , Chen I-Tung , Wei Yuliang , Liang Mengqing , Dai Ping , Nuez-Ortin Waldo G. , Xu Houguo
Published: August 2024

Vibrio genus is a common pathogen in aquaculture and causes acute hepatopancreatic necrosis disease (AHPND) and massive mortality of shrimp. Many studies have suggested that a single functional ingredient such as plant extract or organic acid can reduce the dependence on antibiotics and promote the growth and immunity of aquatic animals. In this study, we evaluated the effects of a phytobiotic-based compound additive (Sanacore® GM, SNGM), which had a successful trajectory of commercial application in fish farming. However, its effects on the hepatopancreas health and intestinal microbiota of shrimp after Vibrio challenge have not been well evaluated. In the present study, Pacific white shrimp were fed diets with or without supplementation of SNGM, and the SNGM grades were 0-g/kg (CON), 3-g/kg (SNGM3), and 5-g/kg (SNGM5) diets. The feed trial lasted 60 days, after which a Vibrio parahaemolyticus challenge was performed. The results showed that compared to the CON group, both the SNGM3 and SNGM5 groups had a significantly higher weight gain and a lower feed conversion ratio as well as higher survival after Vibrio parahaemolyticus challenge. In the growth trial, the SNGM3 group had a significantly increased total protein, albumin concentration, and acid phosphatase activity in hemolymph compared to the CON group. In the challenge experiment, the SNGM3 and SNGM5 groups had increased albumin and glucose contents as well as the activities of phenoloxidase, lysozyme, alkaline phosphatase, and superoxide dismutase in hemolymph. Both the SNGM3 and SNGM5 groups had improved morphology of the hepatopancreas and intestine. The SNGM5 group had alleviated gut microbiota dysbiosis induced by Vibrio infection by increasing the potential probiotic bacterium abundance (Shewanella) and decreasing the potential pathogenic bacteria abundance (Vibrio, Photobacteriuma, Pseudoalteromonas, and Candidatus_Bacilloplasma). In conclusion, the dietary phytobiotic-based additive at 3-g/kg level increased the growth and Vibrio parahaemolyticus resistance of Pacific white shrimp by promoting immune-related enzyme activities and improving the morphological structure of the hepatopancreas and intestine and the intestinal microbiota composition.
Inflammation mechanism and research progress of COPD
Authors: Xu Jiao , Zeng Qingyue , Li Shuangqing , Su Qiaoli , Fan Hong
Published: August 2024

Chronic obstructive pulmonary disease (COPD) is a common respiratory disease characterized by irreversible progressive airflow limitation, often manifested by persistent cough, sputum production and other respiratory symptoms that pose a serious threat to human health and affect the quality of life of patients. The disease is associated with chronic inflammation, which is associated with the onset and progression of COPD, but anti-inflammatory therapy is not first-line treatment. Inflammation has multiple manifestations and phenotypes, and this heterogeneity reveals different patterns of inflammation, making treatment difficult. This paper aims to explore the direction of more effective anti-inflammatory treatment by analyzing the nature of inflammation and the molecular mechanism of disease occurrence and development in COPD patients, and to provide new ideas for the treatment of COPD patients.
Master regulator: p53’s pivotal role in steering NK-cell tumor patrol
Authors: Wang Haohao , Chen Qingjie , Liu Qinghua , Luo Changjiang
Published: August 2024

The p53 protein, encoded by TP53, is a tumor suppressor that plays a critical role in regulating apoptosis, cell cycle regulation, and angiogenesis in tumor cells via controlling various downstream signals. Natural killer (NK) cell-mediated immune surveillance is a vital self-defense mechanism against cancer and other diseases, with NK cell activity regulated by various mechanisms. Among these, p53 plays a significant role in immune regulation by maintaining the homeostasis and functionality of NK cells. It enhances the transcriptional activity of NK cell-activating ligands and downregulates inhibitory ligands to boost NK cell activation and tumor-killing efficacy. Additionally, p53 influences NK cell cytotoxicity by promoting apoptosis, autophagy, and ferroptosis in different tumor cells. p53 is involved in the regulation of NK cell activity and effector functions through multiple pathways. p53 also plays a pivotal role in the tumor microenvironment (TME), regulating the activity of NK cells. NK cells are critical components of the TME and are capable of directly killing tumor cells. And p53 mutates in numerous cancers, with the most common alteration being a missense mutation. These mutations are commonly associated with poor survival rates in patients with cancer. This review details p53’s role in NK cell tumor immunosurveillance, summarizing how p53 enhances NK cell recognition and tumor destruction. We also explore the potential applications of p53 in tumor immunotherapy, discussing strategies for modulating p53 to enhance NK cell function and improve the efficacy of tumor immunotherapy, along with the associated challenges. Understanding the interaction between p53 and NK cells within the TME is crucial for advancing NK cell-based immunotherapy and developing p53-related novel therapeutics.
Xanthogranulomatous pyelonephritis in a patient with polycystic kidney disease without underlying risk factors: a case report
Authors: Kang Yoomee , Lee Tae Won , Bae Eunjin , Jang Ha Nee , Jung Sehyun , Lee Seunghye , Chang Se-Ho , Park Dong Jun
Published: August 2024

Xanthogranulomatous pyelonephritis (XGP) is an extremely rare, chronic granulomatous inflammatory condition thought to arise secondary to a combination of obstruction, recurrent bacterial infection and an incomplete immune response although the etiology of XGP is more complex. We would like to report a case of XGP occurring in a patient with polycystic kidney disease (PCKD), which has not been previously documented in etiology. A 29-year-old woman presented to our hospital with right upper quadrant pain for 5 days. She had experienced a low-grade fever, generalized weakness, and myalgia throughout her body for 2 weeks. She had no history of renal stones or recurrent UTIs. Contrast-enhanced CT revealed a well-enhancing large septated cystic mass in the right kidney and numerous cysts in the liver and both kidneys. Open right radical nephrectomy was performed due to the suspicion of renal cell carcinoma, as there was no response to antibiotics over 7 days. Gross specimen demonstrated architectural distortion due to xanthomatous nodules and a dilated pelvico-calyceal system filled with pus and blood. Microscopic examination revealed infiltration of neutrophils and lipid-laden macrophages. The patient is currently being followed up in the outpatient clinic without recurrence of XGP. This is the first reported case of XGP in a patient with underlying PCKD. Physicians should consider PCKD as a potential underlying cause of XGP.
Mycobacterium marinum hand infection: a case report and literature review
Authors: Liu Chunping , Hao Jiahao , Song Minghui , Ye Jiaqing , Zheng Cuiying , Huang Yinqi , Feng Zhongjun , Jiang Ruiping , Shi Yan , Gao Weili , Zuo Huifen , Zhao Zhenjun , Zhang Lijie
Published: August 2024

Mycobacterium marinum, a photochromogenic, slow-growing mycobacterium, thrives in both marine and freshwater environments. Optimal growth occurs between 25°C and 35°C, with survival becoming challenging above 37°C. Typically, M. marinum enters the body via skin abrasions, often leading to infections of the upper extremities. Diagnosis of M. marinum infection is frequently challenging and delayed due to the difficult pathogen identification. At present, a standardized treatment protocol has yet to be established. Presented herein is a case study detailing an infection of the right hand's middle finger caused by M. marinum. Notably, his occupation as a chef, handling fish and seafood post-injury, was a significant factor. Histological examination of the skin biopsy and positive acid-fast staining were consistent with a diagnosis of mycobacterial infection. Pathological examination confirmed a skin infection with infectious granuloma, and tissue section acid-fast staining revealed acid-fast bacill. Cultures on Columbia blood agar yielded rough, flattened, yellow-fleshy colonies after 10 days, which was identified as M. marinum through 16S rRNA sequencing. The patient responded well to a 3-month regimen of oral moxifloxacin (0.4 qd) and linezolid (0.6 qd), resulting in rash resolution and pain relief, with no recurrence observed for 1-year follow-up. This report presents the first documented acid-fast staining images of M. marinum tissue sections and colony morphology photographs, offering an in-depth view of M. marinum's morphological characteristics. It aims to enhance awareness of M. marinum infections, underscore the necessity for clinicians to delve into patient histories, and provide a review of the clinical manifestations, diagnostic techniques, therapeutic approaches, and pathogenic mechanisms associated with M. marinum.