bluuebunny/crossref_metadata_2025 huggingface dataset:
Inclusive J/ψ photoproduction at the ILC within the framework of non-relativistic QCD
Authors: Zhan Xi-Jie , Wu Xing-Gang , Zheng Xu-Chang
Published: September 2022

Abstract

Based on the non-relativistic quantum chromodynamics factorization framework, we study the inclusive J/ψ photoproduction at the future high energy e+e− collider, International Linear Collider(ILC), where the initial photons come from the back-scattering of laser and electron (positron). The intermediate states, $$ c\overline{c} $$
c

c
¯

(3$$ {S}_1^{\left[\mathbf{1}\right]} $$

S
1

1

,1$$ {S}_0^{\left[\mathbf{8}\right]} $$

S
0

8

,3$$ {S}_1^{\left[\mathbf{8}\right]} $$

S
1

8

, 3$$ {P}_{0,1,2}^{\left[\mathbf{8}\right]} $$

P

0
,
1
,
2

8

), and resolved photoproduction processes are considered. Numerical results show that the cross section of J/ψ photoproduction at the ILC could be very large, and the single resolved pro- cess via $$ c\overline{c} $$
c

c
¯

(3$$ {S}_0^{\left[\mathbf{8}\right]} $$

S
0

8

) intermediate state dominates primarily the production. We also present various kinematic distributions for J/ψ photoproduction. Combining the high luminosity of the collision, J/ψ photoproduction at the ILC shall provide a good platform to test the NRQCD factorization.
Dimension preserving approximation
Authors: Verma S. , Massopust P. R.
Published: September 2022

This article introduces the novel notion of dimension preserving approximation for continuous functions defined on [0, 1] and initiates the study of it. Restrictions and extensions of continuous functions in regards to fractal dimensions are also investigated.
Ozone ageing: experimental methods on pristine and protected natural rubber
Authors: Treib Caroline , Loos Klara , Johlitz Michael , Lion Alexander
Published: September 2022

Many industrial applications require natural rubber (NR) as an irreplaceable polymer for its unique behaviour as its resistance to crack growth. The damage caused by ozone, seen as an ageing accelerator, influences the lifetime of rubber components. The data on ozone-induced ageing experiments are often incomplete or remain unpublished, whereas comprehensive databases for other environmental loads as oxygen do exist. A variety of experimental methods is used to investigate the ageing mechanism of ozone. The ultimate scope is to collect physically based data suitable to include it in thermo-mechanical modelling of the material’s full behaviour. Therefore, NR mixtures, without and with antiozonants: p-phenylenediamine (PPD) and paraffinic wax, are analysed. First, an accelerated, artificial ageing method is developed to reconstruct the real ageing in the laboratory. Experiments conducted henceforth are microhardness tests, uniaxial tensile tests and IR spectroscopy to determine the elastic modulus, the stress response and molecular change due to ageing. Independent of static deformation during the ageing process, both antiozonants show a significant protection effect up to the maximum loading with 75 pphm ozone concentration for 111 h at 50% relative humidity and 40 $$^\circ $$

∘

C. Paraffinic wax completely prevents measureable mechanical change and no surface cracks are visible, though IR spectra reveal ageing-induced molecular reactions, whereas the pristine and soley 6PPD protected compounds are clearly distinguishable by their surface crack picture. Neither of the material compounds, loaded with or without strain during ozone-ageing, contains cracks of a depth further than 300 $$\upmu {\textrm{m}}$$

μ
m

. The data generated on ozone ageing of rubber helps to distinguish it from thermo-oxidative ageing that is described comprehensively in the literature. In conclusion, the data proves the degradation and quantifies some characteristic material changes caused by ozone loading.
Uniqueness and Weak-BV Stability for $$2\times 2$$ Conservation Laws
Authors: Chen Geng , Krupa Sam G. , Vasseur Alexis F.
Published: September 2022

Let a 1-d system of hyperbolic conservation laws, with two unknowns, be endowed with a convex entropy. We consider the family of smallBVfunctions which are global solutions of this equation. For any smallBVinitial data, such global solutions are known to exist. Moreover, they are known to be unique amongBVsolutions verifying either the so-called Tame Oscillation Condition, or the Bounded Variation Condition on space-like curves. In this paper, we show that these solutions are stable in a larger class of weak (and possibly not evenBV) solutions of the system. This result extends the classical weak-strong uniqueness results which allow comparison to a smooth solution. Indeed our result extends these results to a weak-BVuniqueness result, where only one of the solutions is supposed to be smallBV, and the other solution can come from a large class. As a consequence of our result, the Tame Oscillation Condition, and the Bounded Variation Condition on space-like curves are not necessary for the uniqueness of solutions in theBVtheory, in the case of systems with 2 unknowns. The method is$$L^2$$L2based, and builds up from the theory of a-contraction with shifts, where suitable weight functionsaare generated via the front tracking method.
Ukraine's Experience with Management of Combat Casualties Using NATO's Four‐Tier “Changing as Needed” Healthcare System
Authors: Kazmirchuk Anatoliy , Yarmoliuk Yurii , Lurin Igor , Gybalo Rostislav , Burianov Olexandr , Derkach Serhii , Karpenko Kostiantyn
Published: September 2022

Introduction

The full‐scale war with Russia on the territory of Ukraine has revealed several problems related to care of the wounded. In this article, we summarize the mechanisms of injury and injuries sustained for the period February to April 2022, focusing on extremity injuries.

Materials and methods

We compared these to a period of lower‐intensity warfare in 2014–2021. In both cases, we report patients treated by the National Military Medical Clinical Center (NMMCC) in Kyiv. We also sought to evaluate the care of the wounded from an organizational viewpoint, taking into account the four‐level system of care also used by the North Atlantic Treaty Organization (NATO). Third, we sought to understand lessons learned that could improve the care of the wounded.

Conclusion

During the 2022 conflict, the percentage of patients with extremity wounds who had long bone fractures increased and the percentage of people with long bone fractures who had bone defects increased, compared with 2014–2021. This may be due to the higher blast energy from the weapons used in the current conflict. Second, we adapted the four‐level NATO system of care. Level 2 (first level hospital) care was provided by civilian hospitals close to the fighting, rather than mobile military hospitals. Level 3 (specialized) and 4 (highly specialized) care were combined into one hospital (NMMCC). This is the first description of flexible use of NATO's four levels. Finally, a major lesson learned was the need to improve use of damage control surgery.
Did medical doctors who order abdominal CT scans during on-call hours truly become worse at clinical reasoning? Yes, they did
Authors: Ersoydan Selin , Yakar Derya , Kasalak Ömer , Kwee Thomas C.
Published: September 2022

Objective

To investigate temporal changes in clinical reasoning quality of physicians who requested abdominal CT scans at a tertiary care center during on-call hours within a 15-year period.

Methods

This retrospective study included 531 patients who underwent abdominal CT at a tertiary care center during on-call hours on 36 randomly sampled unique calendar days in each of the years between 2005 and 2019. Clinical reasoning quality was expressed as a percentage (0–100%), taking into account the degree by which the differential diagnoses on the CT request form matched the CT diagnosis. Temporal changes in the quality of clinical reasoning and number of CT scans were assessed using Mann-Kendall tests. Associations between the quality of clinical reasoning with patient age and gender, requesting department, and time of CT scanning were determined with linear regression analyses.

Results

The median annual clinical reasoning score was 14.7% (interquartile range: 12.2 to 16.0%; range: 7.7 to 34.6%). The quality of clinical reasoning significantly decreased between 2005 and 2019 (Mann-Kendall Tau of −0.390, p = 0.048), while the number of abdominal CT scans significantly increased (Mann-Kendall tau of 0.790, p < 0.001).

Conclusion

The clinical reasoning quality of physicians who request abdominal CT scans during on-call hours has deteriorated over time. Clinical reasoning appears to be worse in younger patients.

Key Points

• In patients with suspected acute abdominal pathology who are scheduled to undergo CT scanning, referring physicians generally have difficulties in making an accurate pretest (differential) diagnosis.

• Clinical reasoning quality of physicians who request acute abdominal CT scans has deteriorated over the years, while the number of CT scans has shown a significant increase.

• Clinical reasoning quality appears to be worse in younger patients in this setting.
Hyperplane patch mixing-and-folding decoder and weighted chamfer distance loss for 3D point set reconstruction
Authors: Furuya Takahiko , Liu Wujie , Ohbuchi Ryutarou , Kuang Zhenzhong
Published: September 2022

3D point set reconstruction is an important and challenging 3D shape analysis task. Current state-of-the-art algorithms for 3D point set reconstruction employ a deep neural network (DNN) having an encoder–decoder architecture. Recently, the decoder DNNs that transform multiple 2D planar patches to reconstruct a 3D shape have seen some success. These “patch-folding” decoders are adept at approximating smooth surfaces in 3D objects. However, 3D point sets generated by these decoders often lack local geometrical details, as 2D planar patches tend to overly constrain the patch folding process. In this paper, we propose a novel decoder DNN for 3D point sets called Hyperplane Mixing and Folding Net (HMF-Net). HMF-Net uses less constrained hyperplane, not 2D plane, patches as its input to the folding process. HMF-Net has, as its core building block, a stack of token-mixing layers to effectively learn global consistency among the hyperplane patches. In addition to HMF-Net, we also propose a novel loss for 3D point set reconstruction called Weighted Chamfer Distance (WCD). WCD tries to weight, or amplify, loss from parts of shape that are highly variable across training samples by emphasizing higher point-pair distance values between a generated point set and a groundtruth point set. This helps the decoder DNN learn shape details better. We comprehensively evaluate our algorithm under three 3D point set reconstruction scenarios, that are, shape completion, shape upsampling, and shape reconstruction from 2D images. Experimental results demonstrate that our algorithm yields accuracies higher than the existing algorithms for 3D point set reconstruction.
Oncohistone interactome profiling uncovers contrasting oncogenic mechanisms and identifies potential therapeutic targets in high grade glioma
Authors: Siddaway Robert , Canty Laura , Pajovic Sanja , Milos Scott , Coyaud Etienne , Sbergio Stefanie-Grace , Vadivel Anguraj Arun Kumaran , Lubanszky Evan , Yun Hwa Young , Portante Alessia , Carette Sheyenne , Zhang Cunjie , Moran Michael F. , Raught Brian , Campos Eric I. , Hawkins Cynthia
Published: September 2022

Histone H3 mutations at amino acids 27 (H3K27M) and 34 (H3G34R) are recurrent drivers of pediatric-type high-grade glioma (pHGG). H3K27M mutations lead to global disruption of H3K27me3 through dominant negative PRC2 inhibition, while H3G34R mutations lead to local losses of H3K36me3 through inhibition of SETD2. However, their broader oncogenic mechanisms remain unclear. We characterized the H3.1K27M, H3.3K27M and H3.3G34R interactomes, finding that H3K27M is associated with epigenetic and transcription factor changes; in contrast H3G34R removes a break on cryptic transcription, limits DNA methyltransferase access, and alters mitochondrial metabolism. All 3 mutants had altered interactions with DNA repair proteins and H3K9 methyltransferases. H3K9me3 was reduced in H3K27M-containing nucleosomes, and cis-H3K9 methylation was required for H3K27M to exert its effect on global H3K27me3. H3K9 methyltransferase inhibition was lethal to H3.1K27M, H3.3K27M and H3.3G34R pHGG cells, underscoring the importance of H3K9 methylation for oncohistone-mutant gliomas and suggesting it as an attractive therapeutic target.
Exposure to work-related violence and/or threats of violence as a predictor of certified sickness absence due to mental disorders: a prospective cohort study of 16,339 Swedish men and women in paid work
Authors: Wijkander Maria , Farrants Kristin , Magnusson Hanson Linda L.
Published: September 2022

Objectives

The aim of this prospective cohort study was to investigate if exposure to work-related violence and/or threats of violence predict certified sickness absence due to mental disorders.

Methods

Information on work-related exposure to violence and/or threats of violence were derived from the biannual Swedish Longitudinal Occupational Survey of Health (SLOSH) study 2012–2016, including individuals in paid work across Sweden and from different occupations/sectors (n = 16,339). Certified sickness absence due to mental disorders were ascertained from register data from the Swedish Social Insurance Agency. Odds ratios of certified sickness absence due to mental disorders according to exposure to work-related violence were estimated using multiple logistic regression. Several potential confounding variables, such as demographic and socio-economic factors, age, sex, cohabitation, children living at home, socio-economic status, educational level, as well as other types of psychosocial work environmental factors, were adjusted for in the analyses.

Results

In the total study sample, 9% reported exposure to violence and/or threats of violence and the prevalence of sickness absence due to mental disorders was 5%. Exposure to work-related violence and/or threats of violence was associated prospectively with certified sickness absence due to mental disorders (odds ratio 1.46, 95% confidence interval 1.17–1.82, p < 0.01). Analysis of possible interaction showed no difference in association when comparing women to men and different age groups.

Conclusions

Exposure to work-related violence and/or threats of violence appear to increase the odds of certified sickness absence due to mental disorders. Preventive measures aiming to lower the risk of exposure is thus of great importance.
BRAF p.V600E genetic testing based on ultrasound-guided fine-needle biopsy improves the malignancy rate in thyroid surgery: our single-center experience in the past 10 years
Authors: Gong Lei , Liu Yan , Guo Xinghong , Wang Chuan , Yan Fei , Liu Jinbo , Hou Xinguo , Chen Li , Liang Kai
Published: September 2022

Purpose

Ultrasound-guided fine-needle aspiration biopsy (UG-FNAB) was implemented in Qilu Hospital of Shandong University in 2015 as a preoperative diagnostic method for thyroid surgery. BRAF p.V600E genetic testing was implemented in 2019. This study evaluated the impact of these two tests on the malignancy rate in patients undergoing thyroidectomy.

Methods

A total of 19,496 patients were included in the study. We retrospectively collected data from patients undergoing thyroid surgery in the Hospital Information System (HIS) of Qilu Hospital of Shandong University from January 2012 to December 2021. Meanwhile, data of FNAB, UG-FNAB, and BRAF p.V600E genetic testing were collected. Differences in means among groups were analyzed via one-way ANOVA, and differences in frequencies were analyzed via Pearson’s chi-squared test.

Results

In this study, the 10-year period was divided into three stages, with the implementation of UG-FNAB in 2015 and that of BRAF p.V600E genetic testing in 2019 as dividing lines. The malignancy rate in thyroid surgery increased significantly during these three stages (48.06% vs. 73.47% vs. 88.17%; P < 0.001). In the same period (May 2019 to December 2021), the malignancy rate in thyroid surgery was significantly different between the Non-FNAB, UG-FNAB, and UG-FNAB-BRAF groups (78.87% vs. 95.63% vs. 98.32%; P < 0.001).

Conclusions

The successful implementation of UG-FNAB and BRAF p.V600E genetic testing improved the malignancy rate in thyroid surgery and reduced unnecessary diagnostic surgery for benign and marginal lesions. It can, therefore, provide a clinical reference for other hospitals.
The effect of a palliative care pathway on medical interventions at the end of life: a pre-post-implementation study
Authors: van der Padt-Pruijsten Annemieke , Leys Maria B. L. , Hoop Esther Oomen-de , van der Heide Agnes , van der Rijt Carin C. D.
Published: September 2022

Purpose

Adequate integration of palliative care in oncological care can improve the quality of life in patients with advanced cancer. Whether such integration affects the use of diagnostic procedures and medical interventions has not been studied extensively. We investigated the effect of the implementation of a standardized palliative care pathway in a hospital on the use of diagnostic procedures, anticancer treatment, and other medical interventions in patients with incurable cancer at the end of their life.

Methods

In a pre- and post-intervention study, data were collected concerning adult patients with cancer who died between February 2014 and February 2015 (pre-PCP period) or between November 2015 and November 2016 (post-PCP period). We collected information on diagnostic procedures, anticancer treatments, and other medical interventions during the last 3 months of life.

Results

We included 424 patients in the pre-PCP period and 426 in the post-PCP period. No differences in percentage of laboratory tests (85% vs 85%, p = 0.795) and radiological procedures (85% vs 82%, p = 0.246) were found between both groups. The percentage of patients who received anticancer treatment or other medical interventions was lower in the post-PCP period (40% vs 22%, p < 0.001; and 42% vs 29%, p < 0.001, respectively).

Conclusions

Implementation of a PCP resulted in fewer medical interventions, including anticancer treatments, in the last 3 months of life. Implementation of the PCP may have created awareness among physicians of patients’ impending death, thereby supporting caregivers and patients to make appropriate decisions about medical treatment at the end of life.

Trial registration number

Netherlands Trial Register; clinical trial number: NL 4400 (NTR4597); date registrated: 2014–04-27.
Consensus statement on smoking cessation in patients with pain
Authors: Iida Hiroki , Yamaguchi Shigeki , Goyagi Toru , Sugiyama Yoko , Taniguchi Chie , Matsubara Takako , Yamada Naoto , Yonekura Hiroshi , Iida Mami
Published: September 2022

Smoking is closely associated with the development of various cancers and tobacco-related illnesses such as cardiovascular and respiratory disorders. However, data are scarce on the relationship between smoking and both acute and chronic pain. In addition to nicotine, tobacco smoke contains more than 4000 different compounds. Although nicotine is not the sole cause of smoking-induced diseases, it plays a critical role in pain-related pathophysiology. Despite the acute analgesic effects of nicotine, long-term exposure leads to tolerance and increased pain sensitivity due to nicotinic acetylcholine receptor desensitization and neuronal plastic changes. The purpose of smoking cessation interventions in smoking patients with pain is primarily not only to reduce their pain and associated limitations in activities of daily living, but also to improve the outcomes of underlying pain-causing conditions and reduce the risks of tobacco-related disorders. This statement aims to summarize the available evidence on the impact of smoking on pain and to inform medical professionals of the significance of smoking cessation in patients with pain.
Short versus standard implants at sinus augmented sites: a systematic review and meta-analysis
Authors: Toledano Manuel , Fernández-Romero Enrique , Vallecillo Cristina , Toledano Raquel , Osorio María T. , Vallecillo-Rivas Marta
Published: September 2022

Background

Short implants are proposed as a less invasive alternative with fewer complications than standard implants in combination with sinus lift. The aim of this systematic review and meta-analysis was to state the efficacy of placing short implants (≤ 6 mm) compared to standard-length implants (≥ 8 mm) performing sinus lift techniques in patients with edentulous posterior atrophic jaws. Efficacy will be evaluated through analyzing implant survival (IS) and maintenance of peri-implant bone (MBL).

Methods

Screening process was done using the National Library of Medicine (MEDLINE by PubMed), EMBASE, the Cochrane Oral Health, and Web of Science (WOS). The articles included were randomized controlled trials. Risk of bias was evaluated according to The Cochrane Collaboration’s tool. Weighted means were calculated. Heterogeneity was determined using Higgins (I2). A random-effects model was applied. Secondary outcomes such as surgical time, patient satisfaction, mucositis and peri-implantitis, pain, and swelling were analyzed.

Results

Fourteen studies (597 patients and 901 implants) were evaluated. IS was 1.02 risk ratio, ranging from 1.00 to 1.05 (CI 95%) (p = 0.09), suggesting that IS was similar when both techniques were used. MBL was higher in patients with standard-length implants plus sinus lift elevation (p = 0.03). MBL was 0.11 (0.01–0.20) mm (p = 0.03) and 0.23 (0.07–0.39) mm (p = 0.005) before and after 1 year of follow-up, respectively, indicating that the marginal bone loss is greater for standard-length implants.

Discussion

Within the limitations of the present study, as relatively small sample size, short dental implants can be used as an alternative to standard-length implants plus sinus elevation in cases of atrophic posterior maxilla. Higher MBL was observed in the groups where standard-length implants were used, but implant survival was similar in both groups. Moreover, with short implants, it was observed a reduced postoperative discomfort, minimal invasiveness, shorter treatment time, and reduced costs.

Clinical Clinical relevance

The low MBL promoted by short implants does contribute to a paradigm shift from sinus grafting with long implants to short implants. Further high-quality long-term studies are required to confirm these findings.
Modification of glass-ionomer cement properties by quaternized chitosan-coated nanoparticles
Authors: Elshenawy Enas A. , El-Ebiary Manal Ahmed , Kenawy El-Refaie , El-Olimy Gehan Abdelmonem
Published: September 2022

Glass ionomers (GICs), because of their qualities, are in a good position to be modified to resist masticatory stresses as permanent posterior restoration and prevent recurrent caries. The purpose of the present study was to evaluate the effect of adding quaternized chitosan-coated mesoporous silica nanoparticles (HTCC@MSNs) to conventional GIC on its mechanical properties, antimicrobial activity and fluoride release and the effect of 1- and 3-month water aging on the studied properties. HTCC@MSNs was synthesized, added to commercially available conventional GIC at 1%, 3%, and 5% by weight forming three experimental groups and compared with plain GIC as a control group. Flexural strength, modulus, Vickers microhardness and wear volumes were evaluated. Antibacterial activity was tested against Streptococcus mutans and fluoride release in de-ionized water was measured. All properties were evaluated before and after one- and three-month aging (n = 10 specimens per test/per time). Two-way ANOVA was used for statistical analysis. Characterization confirmed successful preparation of HTCC@MSNs. The flexural strength, modulus, hardness and wear resistance of the GICs improved significantly by adding 1–3% HTCC@MSNs, while 5% HTCC@MSNs group showed no significant difference compared to control group. Bacterial inhibition zones and fluoride release increased proportionally to the amount of filler added. Mechanical properties were improved by artificial aging. Fluoride release values, and bacterial inhibition zones decreased with aging for all groups. HTCC@MSNs as a filler with the optimized proportion provides strengthening and antibacterial effect. In addition, aging is an important factor to be considered in evaluating experimental fillers.
How Carequality, The Sequoia Project, and eHealth Exchange Support the Interoperable Exchange of Health Data in the USA
Authors: Davis Blanca “Didi” , Swenson Alan
Published: September 2022

Every organization in the health IT industry plays an important role in overcoming barriers to health information exchange in the United States. It is important to understand imaging interoperability in the overall context of Health Information Exchange (HIE). The rapid evolution of storage, bandwidth and network transport technologies has made the handling of imaging data converge with the primarily text-based healthcare data. The radiology community must understand the overall environment and become a tightly integrated part of it. As the health IT ecosystems continue to evolve, it became clear that there would not be a single health information exchange network to service the nation. Rather, like other industries such as telecom and banking, there would be multiple networks that would need to interconnect. To support compliance to interoperability standards and specifications, The Sequoia Project began collaborating with industry to create testing programs and tooling that supports transport, security and content testing requirements for four production testing programs today. These testing programs validate compliance to standards for transport and security as well standards for the payloads such as clinical documents and imaging data. While once operating under the same umbrella, The Sequoia Project, Carequality and eHealth Exchange (https://ehealthexchange.org/) have been separate companies since 2018. Each plays a unique role in helping patient information move where and when it is needed, each working with a framework of standards published by IHE, DICOM, and HL7 to enable health information exchange.
Treprostinil Supplementation Ameliorates Hepatic Ischemia Reperfusion Injury and Regulates Expression of Hepatic Drug Transporters: An Isolated Perfused Rat Liver (IPRL) Study
Authors: Almazroo Omar Abdulhameed , Shaik Imam H , Hughes Christopher B , Humar Abhinav , Venkataramanan Raman
Published: September 2022

Purpose

IR injury is an unavoidable consequence in deceased donor liver transplantation. Cold preservation and warm reperfusion may change the expression and function of drug transporters in the liver due to vasoconstriction, infiltration of neutrophils and release of cytokines. We hypothesize that vasodilation, anti-platelet aggregation and proinflammatory downregulation activities of treprostinil will diminish the IR injury and its associated effects.

Methods

Livers obtained from male SD rats (n = 20) were divided into 1) Control, 2) IR, 3) Treprostinil-1 (preservation only), and 4) Treprostinil-2 (preservation and reperfusion) groups. Control livers were procured and immediately reperfused. Livers in the other groups underwent preservation for 24 h and were reperfused. All the livers were perfused using an Isolated Perfused Rat Liver (IPRL) system. Periodic perfusate, cumulative bile samples and liver tissue at the end of perfusion were collected. Liver injury markers, bile flow rates, m-RNA levels for uptake and efflux transporters (qRT-PCR) were measured.

Results

Cold preservation and warm reperfusion significantly increased the release of AST and ALT in untreated livers. Treprostinil supplementation substantially reduced liver injury. Bile flow rate was significantly improved in treprostinil-2 group. m-RNA levels of Slc10a1, Slc22a1, and Slc22a7 in liver were increased and m-RNA levels of Mdr1a were decreased by IR. Treprostinil treatment increased Abcb11 and Abcg2 m-RNA levels and maintained Slc22a1m-RNA similar to control livers.

Conclusions

Treprostinil treatment significantly reduced liver injury. IR injury changed expression of both uptake and efflux transporters in rat livers. Treprostinil significantly altered the IR injury mediated changes in m-RNA expression of transporters.
Isoperimetric Inequalities for the Magnetic Neumann and Steklov Problems with Aharonov–Bohm Magnetic Potential
Authors: Colbois Bruno , Provenzano Luigi , Savo Alessandro
Published: September 2022

We discuss isoperimetric inequalities for the magnetic Laplacian on bounded domains of $${\mathbb {R}}^2$$

R

2

endowed with an Aharonov–Bohm potential. When the flux of the potential around the pole is not an integer, the lowest eigenvalue for the Neumann and the Steklov problems is positive. We establish isoperimetric inequalities for the lowest eigenvalue in the spirit of the classical inequalities of Szegö–Weinberger, Brock and Weinstock, the model domain being a disk with the pole at its center. We consider more generally domains in the plane endowed with a rotationally invariant metric, which include the spherical and the hyperbolic case.
Symplectic Flatness and Twisted Primitive Cohomology
Authors: Tseng Li-Sheng , Zhou Jiawei
Published: September 2022

We introduce the notion of symplectic flatness for connections and fibre bundles over symplectic manifolds. Given an $$A_\infty $$

A
∞

-algebra, we present a flatness condition that enables the twisting of the differential complex associated with the $$A_\infty $$

A
∞

-algebra. The symplectic flatness condition arises from twisting the $$A_\infty $$

A
∞

-algebra of differential forms constructed by Tsai, Tseng and Yau. When the symplectic manifold is equipped with a compatible metric, the symplectic flat connections represent a special subclass of Yang–Mills connections. We further study the cohomologies of the twisted differential complex and give a simple vanishing theorem for them.
Distributional learning in multi-objective optimization of recommender systems
Authors: Candelieri Antonio , Ponti Andrea , Giordani Ilaria , Bosio Anna , Archetti Francesco
Published: September 2022

Metrics such as diversity and novelty have become important, beside accuracy, in the design of Recommender Systems (RSs), in response the increasing users' heterogeneity. Therefore, the design of RSs is now increasingly modelled as a multi-objective optimization problem (MOP) for whose solution Multi-objective evolutionary algorithms (MOEAs) have been increasingly considered. In this paper we focus on the k-top recommendation problem in which a solution is encoded as a matrix whose rows correspond to customers and column to items. The value of accuracy, novelty, and coverage for each candidate list, is evaluated as a sample and can be represented as a 3-d histogram which encodes the knowledge obtained from function evaluations. This enables to map the solution space into a space, whose elements are histograms, structured by the Wasserstein (WST) distance between histograms. The similarity between 2 users in this probabilistic space is given by the Wasserstein distance between their histograms. This enables the construction of the WST graph whose nodes are the users and the weights of the edges are the WST distance between users. The clustering of users takes then place in the WST-graph. In the optimization phase the difference between two top-k lists can be encoded as the WST distance between their 3-dimensional histograms. This enables to derive new selection operators which provide a better diversification (exploration). The new algorithm Multi-objective evolutionary optimization/Wasserstein (MOEA/WST), compared with the benchmark NSGA-II, yields better hypervolume and coverage, in particular at low generation counts.
Multidimensional racism classification during COVID-19: stigmatization, offensiveness, blame, and exclusion
Authors: Pei Xin , Mehta Deval
Published: September 2022

Transcending the binary categorization of racist texts, our study takes cues from social science theories to develop a multidimensional model for racism detection, namely stigmatization, offensiveness, blame, and exclusion. With the aid of BERT and topic modelling, this categorical detection enables insights into the underlying subtlety of racist discussion on digital platforms during COVID-19. Our study contributes to enriching the scholarly discussion on deviant racist behaviours on social media. First, a stage-wise analysis is applied to capture the dynamics of the topic changes across the early stages of COVID-19 which transformed from a domestic epidemic to an international public health emergency and later to a global pandemic. Furthermore, mapping this trend enables a more accurate prediction of public opinion evolvement concerning racism in the offline world, and meanwhile, the enactment of specified intervention strategies to combat the upsurge of racism during the global public health crisis like COVID-19. In addition, this interdisciplinary research also points out a direction for future studies on social network analysis and mining. Integration of social science perspectives into the development of computational methods provides insights into more accurate data detection and analytics.
Analysis and optimization of energy flow in the full chain of carbon dioxide capture and oil recovery
Authors: Zhang Fu-Zhen , Xu Rui-Na , He Ying-Fu , Fang Xin , Jiang Pei-Xue
Published: September 2022

CO2 capture is a process with a high energy consumption, and its large-scale implementation should be based on comprehensive analysis of its impact on the energy, economy, and environment. The process of injecting CO2 into existing oil fields is a well-known enhanced oil recovery (CO2-EOR) technique. Using CO2 as a working fluid to recover oil can compensate for the energy consumption of the capture and transport processes, increasing the feasibility of CO2 capture while achieving carbon sequestration. In this study, a full-chain CO2 capture, utilization, and storage (CCUS) system based on the post-combustion capture method is deconstructed and coupled. A full-chain energy consumption calculation software is developed, and optimization analysis of the energy consumption system is conducted. The energy budget of the oil displacement utilization is deconstructed, and the advantages of the water alternating gas (WAG) method are clarified from an energy budget point of view. The analysis reveals that the benefits of CO2-EOR are far greater than the energy consumption of other CCUS processes, and CCUS-EOR is a CO2 utilization method with positive energy benefits. Based on the simulation of the effects of N2 and CH4 on the recovery factor, a multi-well combined injection-production method is proposed, and the reasons for increasing profit are analyzed.
Rethinking Authority in China's Border Regime
Authors: Plümmer Franziska
Published: September 2022

In the twenty-first century, governments around the globe are faced with the question on how to tackle new migratory mobilities. Governments increasingly become aware of irregular immigration and are forced to re-negotiate the dilemma of open but secure borders. Rethinking Authority in China's Border Regime: Regulating the Irregular investigates the Chinese government's response to this phenomenon. Hence, this book presents a comprehensive analysis of the Chinese border regime. It explores the regulatory framework of border mobility in China by analysing laws, institutions, and discourses as part of an ethnographic border regime analysis. It argues that the Chinese state deliberately creates 'zones of exception' along its border. In these zones, local governments function as 'scalar managers' that establish cross-border relations to facilitate cross-border mobility and create local migration systems that build on their own notion of legality by issuing locally valid border documents. The book presents an empirically rich story of how border politics are implemented and theoretically contributes to debates on territoriality and sovereignty as well as to the question of how authority is exerted through border management. Empirically, the analysis builds on two case studies at the Sino-Myanmar and Sino-North Korean borders to illustrate how local practices are embedded in multiscalar mobility regulation including regional organizations such as the Greater Mekong Subregion and the Greater Tumen Initiative.
A case study approach to understanding the pathway to individualised funded supports under the National Disability Insurance Scheme for community-dwelling individuals with acquired brain injury
Authors: Skinner Michael , Quinn Ray , Nance Judith , Wright Suzanne , Kendall Melissa
Published: September 2022

Background:

The National Disability Insurance Scheme (NDIS) offers opportunity against a historical background of underfunded and fragmented services for people with disability. For people with acquired brain injury (ABI), concerns have been raised about how they access NDIS individualised funded supports. The aim of this research was to explore how community-dwelling individuals with ABI in Queensland navigate the NDIS participant pathway to individualised funded supports.

Methods:

This study used a multiple case study design within a policy implementation framework. Twelve people with ABI, nine family members and eight NDIS funded and mainstream service providers participated. Data was collected from relevant NDIS documentation, health records and semi-structured interviews with individuals with ABI, family members, and service providers.

Results:

The current study highlighted the complexity of navigating the NDIS participant pathway of access, planning, implementation and review for people with ABI, their family and service providers. The NDIS pathway was impacted by the insurance and market based NDIS model itself, time, communication, and the requirement for external supports. Equally, the process was affected by environmental factors, individual person and injury factors as well as service providers, with a range of outcomes evident at the individual, family and system level.

Conclusions:

Findings suggest that the NDIS has struggled to make specific allowance for people with ABI and the complexity of their disabilities. Providing people with ABI access to the NDIS Complex Support Needs Pathway may redress many of the difficulties people with ABI experience accessing and using NDIS funded supports.
OPPOSITION TO BUDDHISM AND THE HAN LEGACY
Authors: Barrett T. H.
Published: September 2022

Michael Loewe has repeatedly and as recently as 2021 looked at how Confucius appears in Han sources and has drawn attention to his lack of prominence, at least to the degree one might expect. Here, a preliminary assessment of the sources of opposition to Buddhism in one key sixth-century c.e. collection of polemics further demonstrates that adherence to mingjiao 名教 (Teaching of a Good Name) or to lijiao 禮教 (teaching on ritual) appears there as the main identifiers of opponents; rujiao, the term often later translated as “Confucianism,” is mentioned but once. While the commitment to values such as filial piety promoted by opponents of Buddhism is clear; their institutional coherence and self-awareness as a group does not seem to have been at all on a par with that of the Buddhist community. That situation did not start to shift until the Tang dynasty.
The moduli of sections has a canonical obstruction theory
Authors: Webb Rachel
Published: September 2022

We give a detailed proof that locally Noetherian moduli stacks of sections carry canonical obstruction theories. As part of the argument, we construct a dualising sheaf and trace map, in the lisse-étale topology, for families of tame twisted curves when the base stack is locally Noetherian.
Prandtl number effects on the hydrodynamic stability of compressible boundary layers: flow–thermodynamics interactions
Authors: Sharma Bajrang , Girimaji Sharath S.
Published: September 2022

Hydrodynamic stability of compressible boundary layers is strongly influenced by the Mach number (

$M$

), Prandtl number (

$Pr$

) and thermal wall boundary condition. These effects manifest on the flow stability via the flow–thermodynamics interactions. Comprehensive understanding of stability flow physics is of fundamental interest and important for developing predictive tools and closure models for integrated transition-to-turbulence computations. The flow–thermodynamics interactions are examined using linear analysis and direct numerical simulations in the following parameter regime:

$0.5 \leq M \leq 8$

; and

$0.5 \leq Pr \leq 1.3$

. For the adiabatic wall boundary condition, increasing Prandtl number has a destabilizing effect. In this work, we characterize the behaviour of production, pressure–strain correlation and pressure dilatation as functions of the Mach and Prandtl numbers. First and second instability modes exhibit similar stability trends but the underlying flow physics is shown to be diametrically opposite. The Prandtl number influence on instability is explicated in terms of the base flow profile with respect to the different perturbation mode shapes.
Amyloid-like Hfq interaction with single-stranded DNA: involvement in recombination and replication inEscherichia coli
Authors: Kubiak Krzysztof , Wien Frank , Yadav Indresh , Jones Nykola C. , Vrønning Hoffmann Søren , Le Cam Eric , Cossa Antoine , Geinguenaud Frederic , van der Maarel Johan R. C. , Węgrzyn Grzegorz , Arluison Véronique
Published: September 2022

Interactions between proteins and single-stranded DNA (ssDNA) are crucial for many fundamental biological processes, including DNA replication and genetic recombination. Thus, understanding detailed mechanisms of these interactions is necessary to uncover regulatory rules occurring in all living cells. The RNA-binding Hfq is a pleiotropic bacterial regulator that mediates many aspects of nucleic acid metabolism. The protein notably mediates mRNA stability and translation efficiency by using stress-related small regulatory RNA as cofactors. In addition, Hfq helps to compact double-stranded DNA. In this paper, we focused on the action of Hfq on ssDNA. A combination of experimental methodologies, including spectroscopy and molecular imaging, has been used to probe the interactions of Hfq and its amyloid C-terminal region with ssDNA. Our analysis revealed that Hfq binds to ssDNA. Moreover, we demonstrate for the first time that Hfq drastically changes the structure and helical parameters of ssDNA, mainly due to its C-terminal amyloid-like domain. The formation of the nucleoprotein complexes between Hfq and ssDNA unveils important implications for DNA replication and recombination.
Do You Use Love to Make it Lovely? The Role of Meaning Overlap across Morphological Relatives in the Development of Morphological Representations
Authors: QUEMART Pauline , WOLTER Julie A. , CHEN Xi , DEACON S. Hélène
Published: September 2022

We examined whether and how the degree of meaning overlap between morphologically related words influences sentence plausibility judgment in children. In two separate studies with kindergarten and second-graders, English-speaking and French-speaking children judged the plausibility of sentences that included two paired target words. Some of these word pairs were morphologically related, across three conditions with differing levels of meaning overlap: low (wait-waiter), moderate (fold-folder) and high (farm-farmer). In another two conditions, word pairs were related only by phonology (rock-rocket) or semantics (car-automobile). Children in both ages and languages demonstrated higher plausibility scores as meaning overlap increased between morphologically related words. Further, kindergarten children rated sentences that included word pairs with phonological overlap as more plausible than second-grade children, while second-grade children rated those with high meaning overlap as more plausible than kindergarten children. We interpret these findings in light of current models of morphological development.
The role of National Red Cross and Red Crescent Societies in the development of international humanitarian law: Lessons learned and perspectives based on the Belgian Red Cross experience
Authors: Casier Frédéric , De Grève Laura
Published: September 2022

National Societies can assist their authorities in the development of international humanitarian law (IHL). This role has been consolidated in their mandate, especially through their auxiliary role in support of public authorities in the humanitarian field. This article recalls the main legal bases from which this role is derived. Based on the Belgian Red Cross experience, it demonstrates how the National Societies’ support to the promotion and national implementation measures of IHL can constitute an incentive for further elaboration of IHL treaties and policies. It also highlights their humanitarian diplomacy work to assist the International Committee of the Red Cross's approach at the international level. Finally, the article shares some thoughts to increase the Movement's collective impact in IHL development.
Development of a Multi‐Region Power System Risk Management Model for Supporting China's Carbon Neutrality Ambition in 2060s
Authors: Li J. Z. , Huang G. H. , Li Y. P. , Chen J. P. , He C. Y.
Published: September 2022

In order to peak emissions before 2030 and to achieve the net‐zero ambition around 2060, China urgently needs to accelerate low‐carbon transition, especially in the power system. Previous studies were mainly focused on deterministic optimization, with some of them being followed by sensitivity analyses. To tackle the gaps and to support the net‐zero ambition, this study develops a multi‐region power system risk management (MPRM) model to analyze composite effects of renewable energy development and inter‐regional electricity transmission under uncertainties, and their combinations to achieve carbon neutrality by 2060. In detail, MPRM can (a) reveal the downward trend in costs of renewable energy and the increasing in inter‐regional electricity transmission; (b) tackle the uncertainties expressed as intervals; (c) support the low‐carbon transition of the power system. Under the renewable‐dominated power structure, 90% of China's electricity demands can be derived from non‐fossil sources by 2060. Inter‐regional electricity transmission will continue to expand due to the dramatic decreases in the costs of renewables and fast‐growing demands for electricity. Northwest and east regions will be the main exporter and importer of renewable electricity. Carbon emissions from power system will peak in 2030 (about 6.21% above the 2020 level) and be eliminated by 96% (of 2030 levels) by 2060. These results can provide support for expansion of renewable capacities, acceleration of low‐carbon transition in power structure, elimination of barriers in electricity trading across regions, and exploration of the trade‐off between system costs and risk.
Chasing Fire Tornadoes for Science
Authors: Shepherd Emily
Published: September 2022

Recent research suggests fire-generated vortices are always present during wildfires.
The Effect of Compression Induced Chorus Waves on 10–100 s eV Electron Precipitation
Authors: Halford A. J. , Garcia‐Sage K. , Mann I. R. , Turner D. L. , Breneman A. W.
Published: September 2022

On 7 January 2014, a solar storm erupted, which eventually compressed the Earth's magnetosphere leading to the generation of chorus waves. These waves enhanced local wave‐particle interactions and led to the precipitation of electrons from 10 s eV to 100 s keV. This paper shows observations of a low energy cutoff in the precipitation spectrum from Van Allen Probe B Helium Oxygen Proton Electron measurements. This low energy cutoff is well replicated by the predicted loss calculated from pitch angle diffusion coefficients from wave and plasma observations on Probe B. To our knowledge, this is the first time a single spacecraft has been used to demonstrate an accurate theoretical prediction for chorus wave‐induced precipitation and its low energy cutoff. The specific properties of the precipitating soft electron spectrum have implications for ionospheric activity, with the lowest energies mainly contributing to thermospheric and ionospheric upwelling, which influences satellite drag and ionospheric outflow.