bluuebunny/crossref_metadata_2025 huggingface dataset:
ALGORİTMALARIN YÖNLENDİRDİĞİ DİNLEME PRATİKLERİ: Sahte Bireyselleşme Bağlamında Kişiye Özel Çalma Listeleri
Authors: ULUBİLGİN ÇUHADAR Burçe , ÇEREZCİOĞLU Aykut Barış
Published: December 2020

Bu çalışmada, dijital müzik medyalarının algoritmalara dayalı kişiye özel çalma listeleri, Deezer özelinde incelenerek bu listelerin “özgürlük” ve “kişiye özel olma” gibi özellikleri anlaşılmaya çalışılacaktır. Yeni medyalar, dinleyiciye kolaylık ve ucuzluk sağlamanın yanında müziğin üretim, dağıtım ve tüketim süreçlerini ile ticari müzik endüstrisinin işleyişini de etkiler. Çok sayıda ve farklı türde müziği barındırması ve dinleyiciye kolay, ucuz bir müzik dinleme deneyimi sağlaması ile günümüzün başlıca müzik dinleme aracına dönüşen dijital müzik medyaları, benzer motivasyonlar ile farklı yerellerdeki pek çok müzisyenin de müziğini dolaşıma sokacağı öncelikli alanlara dönüşür. Bu durum, dinleyicinin çok sayıda seçenek arasında kimi görüşe göre özgürleşmesinin önünü açarken farklı bir bakış açısı ile milyonlarca şarkı arasında neyi dinleyeceğini bilemeyen ve yönlendirmelere açık hale gelen bir dinleyici profiline neden olmaktadır. Yapay zekâ teknolojileri ve algoritmaların kullanıldığı kişiye özel çalma listeleri ise bu platformlar tarafından kararsız dinleyicinin yol göstericisi konumunda resmedilir. Bu yol gösterme haline müzisyenler, dinleyiciler ve yayıncıların duyduğu şüphe hali ise kişiye özel çalma listelerinin “kişiye özellik” durumunu sorgulamamıza ve kültür endüstrisi paradigmasının belirli unsurlarını yeniden gözden geçirmemize neden olur. Bu çerçevede çalışmamız gerek müzik incelemesi gerekse Kültürel Çalışmalar ve medya çalışmaları ile ortaklıklar sağlar.Çalışmada, dijital müzik medyalarının algoritmalara dayalı kişiye özel çalma listeleri, Deezer özelinde incelenerek alan çalışması verileri ile aktarılır. Bu listelerin “özgürlük” ve “kişiye özellik” durumlarındaki şüphe hali ise kültür endüstrisinin belirli parametreleri ve sahte bireyselleşme kavramları ile aktarılır.
KAJIAN TUNDAAN LALU LINTAS PADA SIMPANG BERSINYAL (Studi Kasus: Simpang Jl. Brigjen Sudiarto - Jl. Majapahit - Jl. Fatmawati Kota Semarang)
Authors: Novianka P Jayanti Rizqi , Hidayati Khrisna Dwi , Supriyadi Supriyadi , Junaidi Junaidi
Published: December 2020

Traffic volume in Semarang City has increased every year due to the increasing number of vehicles. Congestion that occurs at the T-junction intersection Jl. Brigjen Sudiarto - Jl. Majapahit is one of the impacts of high traffic growth and the traffic system is not functioning properly. By considering the geometric conditions of the road, traffic volume, side obstacles and the intersection environment which is a commercial area, it is necessary to analyze the cause of the congestion at the intersection. The research conducted was to conduct a field survey to obtain primary and secondary data which are then processed using intersection management. Planning uses the 1997 Indonesian Road Capacity Manual (MKJI) and uses the Excel 2013 program to process traffic data. Traffic data is obtained from recording the number of vehicles in the field for 3 days (April 29, 01 and May 4, 2019) during peak hours and presented in the form of a vehicle data table, then the behavior of the intersection can be analyzed. From the analysis results obtained value of the degree of saturation (DS) at the intersection of Jl. Brigjen Sudiarto - Jl. Majapahit 0.991. This value has exceeded the required value by the 1997 MKJI, DS ≤ 0.85. The analysis shows that the average traffic delay is 141,320 sec / pcu, so this intersection has a Service Level (LOS) F (> 60).
The Translatability of Cultural Elements in Yaşar Kemal’s Orta Direk
Authors: KAYA SOYKAN Didem
Published: December 2020

This article aims to analyse cultural items in the German translations of Yaşar Kemal’s novel Orta Direk as Der Wind aus der Ebene by Helga and Yıldırım Dağyeli and Margerete Bormann. To this end, it attempts to find answers to the following questions: Is it possible to translate the culture of a society into another language? Do these cultural items find expression in the target language or do they fail at the limit of translatability? To find an answer to these questions, the cultural elements identified in the novel were first classified according to Peter Newmark’s categorisation of “cultural term” (2010). Then these elements were analysed according to the translating procedure. For this purpose, the methods used for the translation of these elements were categorised as foreignisation and domestication suggested by Lawrence Venuti (1998). It was found that the domestic translation strategy was predominantly applied to the analysed cultural elements. Few cultural specifics were translated using foreignisation. This conclusion shows that while cultural elements of the source language found expression in the target language in a way, some aspects of the source language culture were lost in the translation.
PERANCANGAN APIKASI MOBILE E-COMMERCE BERBASIS ANDROID PADA TOKO SEMBAKO BERKAH JAYA DIERA COVID-19
Authors: Abdul Aziz Akhmad , Fajar K Fitrah Satrya
Published: December 2020

Toko Sembako Berkah Jaya adalah salah satu toko yang menjual berbagai sembako yang berada dikota Bogor, Jl.Asrama Palad Blok B No.10, RT.2/RW.5 Cirimekar, Cibinong. Sistem yang sedang berjalan saat ini masih dinilai belum efektif dalam hal pemasaran apa lagi dimasa pandemi seperti ini, pelanggan selalu menginginkan kemudahan ataupun kecepatan informasi yang relevan untuk memudahkan segala aktivitasnya tanpa harus keluar rumah, salah satunya pemesanan ataupun pembelian sembako pada Toko Sembako Berkah Jaya. Penelitian ini bertujuan membantu pelanggan agar dapat berbelaaknja dimana pun dan kapan pun yang diinginkan secara flexible tanpa harus keluar rumah dan pergi ketoko tersebut. Jadi maksud dari penelitian ini untuk mengurangi terjadinya penularan covid-19 maka saya ingin membuat perancangan aplikasi mobile e-commerce berbasis android untuk penjualan sembako pada Toko Sembako Berkah Jaya. Dalam membangun sistem ini penulis menggunakan metode prototype dimana teknik pengumpulan data yang dilakukan adalah wawancara dan studi pustaka. Sedangkan dalam membantu analisis dan perancangan sistem menggunakan Unified Modeling Language  dengan dibuatnya aplikasi mobile e-commerce berbasis android untuk penjualan sembako pada Toko Sembako Berkah Jaya dapat memudahkan pelanggan dalam melakukan transaksi pemesanan dan mendapatkan informasi tentang Toko Sembako Berkah Jaya dan mengurangi terjadinya penularan covid-19.
Narrativas em disputa: desmantelando o sujeito universal e demarcando pontos de partida “O que é lugar de fala?” de Djamila Ribeiro Por Gabriela Monteiro
Authors: MONTEIRO Gabriela
Published: December 2020

Resenha do livro O que é lugar de fala? é o primeiro livro da coleção Feminismos Plurais, lançado em 2017 e escrito pela ativista e intelectual Djamila Ribeiro. Nele a autora se propõe a desestabilizar as narrativas hegemônicas ao desmontar a falácia da voz universal e expor as diferentes condições sociais dos grupos para acessar lugares de cidadania. Propondo outros marcos epistêmicos e trazendo diversas referências da produção de conhecimento das feministas negras, Djamila denuncia como as relações de poder legitimam ou deslegitimam determinadas categorias a falar – e mesmo a existir. O livro também está sendo um fenônemo político de articulação e visibilidade, com eventos de lançamentos mobilizando milhares de mulheres negras brasileiras em todo o país. A presente resenha aborda os significados e inspirações do livro e da coleção e também conta com uma entrevista com a autora, num diálogo entre mulheres negras.Sujeito. Narrativas. Disputa. Djamila RibeiroNarratives in dispute: dismantling the universal subject and demarcating starting points "What is a place of speech?" - Djamila Ribeiroabstract "What is the place of speech?" is the first book in the Feminismos Plurais collection, published in 2017 and written by activist and intellectual Djamila Ribeiro. In this book, the author proposes to destabilize the hegemonic narratives by dismantling the fallacy of the universal voice and exposing the different social conditions of the groups to access places of citizenship. By proposing other epistemic milestones and bringing various references to black feminist knowledge production, Djamila denounces how power relations legitimize or delegitimize certain categories to speak - and even to exist. The book is also being a political phenomenon of articulation and visibility, with launch events mobilizing thousands of Brazilian black women throughout the country. This review addresses the meanings and inspirations of the book and the collection and also features an interview with the author in a dialogue among black women.Subject. Narratives. Disputes. Djamila Ribeiro
Coagulant potentials of Moringa oleifera seeds in water purification
Authors: Thorat R. V. , Malvekar D. A. , Sutar A. U.
Published: December 2020

The main objective of this study is to confirm the potentials of Moringa oleifera seeds over alum for water purification. Various doses of Moringa seed powder 4, 8, 12 g/l were taken and checked for treatment of river and sewage water. After treatment of seed powder with water samples were analyzed for physico-chemical parameters like pH, Absorbance, TDS, TSS, Hardness, Chlorides, Conductivity, Turbidity, MPN and DO. Almost all parameters showed reduction with increasing dosage of Moringa seed powder. Similar doses of alum were checked with river water sample and were analyzed for above mentioned
parameters. The results obtained showed that seed powder (natural coagulant) is more effective than conventional chemical coagulant., alum. The seed of Moringa oleifera is cheap, eco-friendly and non-toxic, can be effectively used as a coagulant for
river and sewage water purification.
Impacts of China's Emissions Trading Scheme on the National and Hong Kong Economies: A Dynamic Computable General Equilibrium Analysis
Authors: Wang Yue , Winchester Niven , Webster Christopher J. , Nam Kyung-Min
Published: December 2020

In this study, we estimate the economic impacts of China's official carbon-mitigation targets, in connection with Hong Kong's potential participation in a proposed national emissions trading scheme. We find that moderate intensity-reduction targets emulating China's pledged Paris Agreement commitment would incur much larger policy-compliance costs in Hong Kong (0.1–2.5% of baseline gross domestic product) than in Mainland China (0.1–0.7%) in each of the modeled years 2021 to 2030 when each economy operates its own independent carbon market. By comparison, an integrated carbon market enables Hong Kong to achieve the same reduction goal at up to 78% lower costs compared to an independent market, and this is achieved without significantly affecting the Mainland's economy. These savings in compliance costs for Hong Kong are greater when pre-integration local carbon prices in both economies are subject to a larger gap. Effectively, the cheaper pre-integration carbon prices in the Mainland indirectly subsidize the Hong Kong economy in the initial years of the integration scenario, buffering the policy shock. In sum, an integrated carbon market in China would improve overall efficiency at the national level, but the benefits are biased toward Hong Kong. This finding suggests that it is in the city's interest to play a more active role in cross-border collaboration on climate mitigation and emissions trading.

JEL classification: C68, Q42, Q52, Q54
Genetic Variation, GWAS and Accuracy of Prediction for Host Resistance to Sparicotyle chrysophrii in Farmed Gilthead Sea Bream (Sparus aurata)
Authors: Aslam Muhammad Luqman , Carraro Roberta , Sonesson Anna Kristina , Meuwissen Theodorus , Tsigenopoulos Costas S. , Rigos George , Bargelloni Luca , Tzokas Konstantinos
Published: December 2020

Gilthead sea bream (Sparus aurata) belongs to a group of teleost which has high importance in Mediterranean aquaculture industry. However, industrial production is increasingly compromised by an elevated outbreak of diseases in sea cages, especially a disease caused by monogeneans parasiteSparicotyle chrysophrii.This parasite mainly colonizes gill tissues of host and causes considerable economical losses with mortality and reduction in growth. The aim of current study was to explore the genetics of host resistance againstS. chrysophriiand investigate the potential for genomic selection to possibly accelerate genetic progress. To achieve the desired goals, a test population derived from the breeding nucleus of Andromeda Group was produced. This experimental population was established by crossing of parents mated in partial factorial crosses of ∼8 × 8 using 58 sires and 62 dams. The progeny obtained from this mating design was challenged withS. chrysophriiusing a controllable cohabitation infection model. At the end of the challenge, fish were recorded for parasite count, and all the recorded fish were tissue sampled for genotyping by sequencing using 2b-RAD methodology. The initial (before challenge test) and the final body weight (after challenge test) of the fish were also recorded. The results obtained through the analysis of phenotypic records (n= 615) and the genotypic data (n= 841, 724 offspring and 117 parents) revealed that the resistance against this parasite is lowly heritable (h2= 0.147 with pedigree and 0.137 with genomic information). We observed moderately favorable genetic correlation (Rg= −0.549 to −0.807) between production traits (i.e., body weight and specific growth rate) and parasite count, which signals a possibility of indirect selection. A locus at linkage group 17 was identified that surpassed chromosome-wide Bonferroni threshold which explained 22.68% of the total genetic variance, and might be playing role in producing genetic variation. The accuracy of prediction was improved by 8% with genomic information compared to pedigree.
Multimorbidity in General Practice: Unmet Care Needs From a Patient Perspective
Authors: Rimmelzwaan Lisanne M. , Bogerd Mieke J. L. , Schumacher Bregitta M. A. , Slottje Pauline , Van Hout Hein P. J. , Reinders Marcel E.
Published: December 2020

Introduction: In the Netherlands, as in many other countries, current clinical guidelines are directed at single diseases. Patients with multiple chronic conditions may benefit from a more patient-tailored approach. Therefore, our objective is to explore the general practice care needs of patients with multimorbidity from a patient perspective. We also assessed their care experiences and the impact of chronic conditions on their daily functioning.

Methods: We conducted a qualitative study, using semi-structured interviews complemented with self-report questionnaire assessments for triangulation, with consenting community-dwelling patients with three or more chronic conditions. Participants were identified through purposeful sampling in three general practices. Two researchers independently coded and thematically analyzed the audiotaped and anonymously transcribed interviews using the constant comparative method. The self-report questionnaire assessments were used to describe the patient characteristics and for triangulation of the data retrieved from the semi-structured interviews.

Results: After 12 interviews, saturation was achieved. Overall, most participants were positive about their relationship with the general practitioner (GP) and practice nurse (PN) as well as the care they received in general practice. However, several unmet care need themes were observed: firstly, lack of a holistic approach (by the GP and PN), in particular, insufficient attention to the patient's state of functioning, their limitations in daily life, and their well-being; secondly, they mentioned that personal continuity of care was important to them and sometimes lacking; thirdly, lack of patient-tailored explanations about diseases and treatments.

Conclusion: From a community-dwelling multimorbid patient perspective, general practice care could benefit from improving personal continuity of care, attention to personal circumstances and daily functioning, and patient-tailored communication.
Seed Viability, Seedling Growth and Yield in White Guinea Yam
Authors: Norman Prince E. , Danquah Agyemang , Asfaw Asrat , Tongoona Pangirayi B. , Danquah Eric Y. , Asiedu Robert
Published: December 2020

The yam is an economic tuber crop utilized for food, feed, and various industrial applications. Botanical seed viability, seedling growth, and development are among factors that influence plant population dynamics, development, structure, and sustainability. However, little is known about seed viability, growth, and yield potential of seed-progenies developed using different mating designs. This study assessed seed germination, seedling growth, and yield traits in seed-progenies developed using North Carolina I (NC-1) and polycross mating designs. For this, seed germination and seedling nursery trials established using seed-progenies from different yam crosses were used. Results revealed that days to first seed germination (DAYFG), days to 50% germination (DAYSG), coefficient of velocity of germination, seed emergence speed (SES), germination index, final germination percent, and seedling vigor index significantly (p < 0.05) varied within and among NC-1 and PC-derived families. The mean days to first seed germination (DFSG) and DAYSG seed-progenies of NC-1 were significantly lower than the polycross progenies. Moreover, the seedling-progenies from the polycross produced a higher number of stems and more elongate tubers than those originated from the NC-1 mating. Progenies of family TDr1687 from a polycross mating were among the families that had the highest stem number (2.2), longest tuber (7.5 cm), and widest tuber (2.8 cm). The inter-family means of both NC-1 and polycross had a non-significant variation for mean tuber weight per plant. Our results suggest the relevance of seed germination and seedling attributes for selection of superior progenies at the early generation stage trials in yam breeding.
Three-Year Trends of Healthcare-Associated Infections and Antibiotic Use in Acute Care Hospitals: Findings from 2016–2018 Point Prevalence Surveys in Sicily, Italy
Authors: Barchitta Martina , Maugeri Andrea , La Rosa Maria Clara , La Mastra Claudia , Murolo Giuseppe , Agodi Antonella
Published: December 2020

Repeated point prevalence surveys (PPSs) of healthcare-associated infections (HAIs) and antibiotic use are crucial to monitor trends over years at regional level, especially in countries with decentralized healthcare systems. Here, we reported the results of three PPSs conducted in Sicilian acute care hospitals (Italy) from 2016 to 2018, according to the European Centre for Disease Prevention and Control protocol. Overall, prevalence of patients with at least one HAI was 5.1% in 2016, 4.7% in 2017, and 5.1% in 2018, without a significant trend over years (p = 0.434). At the patient level, the most important factor associated with HAIs was antibiotic use, since patients receiving at least one antimicrobial were more likely to be infected than those who did not receive antimicrobials (OR = 18.87; 95%CI = 13.08–27.22). The analysis of the prevalence of antibiotic use indicated a significant trend across years of the PPSs: 50.5% of patients received at least one antimicrobial agent in 2016, 55.2% in 2017, and 53.7% in 2018 (p < 0.001). The most common indication for antimicrobial prescription was medical prophylaxis, while third-generation cephalosporins represented the most frequently used class of antimicrobial agents, followed by fluoroquinolones and combinations of penicillins. Our study confirms that HAIs still remain a major public health issue, which could be intensified by antibiotic abuse. This raises the need for infection prevention and control and antibiotic stewardship programs aimed to improve knowledge about appropriate antibiotic prescription and to reduce the use of broad-spectrum antimicrobials.
Systematic Quantification of Cell Confluence in Human Normal Oral Fibroblasts
Authors: Chiu Ching-Hsiang , Leu Jyh-Der , Lin Tzu-Ting , Su Pin-Hua , Li Wan-Chun , Lee Yi-Jang , Cheng Da-Chuan
Published: December 2020

Background: The accurate determination of cell confluence is a critical step for generating reasonable results of designed experiments in cell biological studies. However, the cell confluence of the same culture may be diversely predicted by individual researchers. Herein, we designed a systematic quantification scheme implemented on the Matlab platform, the so-called “Confluence-Viewer” program, to assist cell biologists to better determine the cell confluence. Methods: Human normal oral fibroblasts (hOFs) seeded in 10 cm culture dishes were visualized under an inverted microscope for the acquisition of cell images. The images were subjected to the cell segmentation algorithm with top-hat transformation and the Otsu thresholding technique. A regression model was built using a quadratic model and shape-preserving piecewise cubic model. Results: The cell segmentation algorithm generated a regression curve that was highly correlated with the cell confluence determined by experienced researchers. However, the correlation was low when compared to the cell confluence determined by novice students. Interestingly, the cell confluence determined by experienced researchers became more diverse when they checked the same images without a time limitation (up to 1 min). Conclusion: This tool could prevent unnecessary human-made mistakes and meaningless repeats for novice researchers working on cell-based studies in health care or cancer research.
Insights from Learning Analytics for Hands-On Cloud Computing Labs in AWS
Authors: Moltó Germán , Naranjo Diana M. , Segrelles J. Damian
Published: December 2020

Cloud computing instruction requires hands-on experience with a myriad of distributed computing services from a public cloud provider. Tracking the progress of the students, especially for online courses, requires one to automatically gather evidence and produce learning analytics in order to further determine the behavior and performance of students. With this aim, this paper describes the experience from an online course in cloud computing with Amazon Web Services on the creation of an open-source data processing tool to systematically obtain learning analytics related to the hands-on activities carried out throughout the course. These data, combined with the data obtained from the learning management system, have allowed the better characterization of the behavior of students in the course. Insights from a population of more than 420 online students through three academic years have been assessed, the dataset has been released for increased reproducibility. The results corroborate that course length has an impact on online students dropout. In addition, a gender analysis pointed out that there are no statistically significant differences in the final marks between genders, but women show an increased degree of commitment with the activities planned in the course.
Development of a New KPI for the Economic Quantification of Six Big Losses and Its Implementation in a Cyber Physical System
Authors: Morella Paula , Lambán María Pilar , Royo Jesús , Sánchez Juan Carlos , Latapia Jaime
Published: December 2020

The purpose of this work is to develop a new Key Performance Indicator (KPI) that can quantify the cost of Six Big Losses developed by Nakajima and implements it in a Cyber Physical System (CPS), achieving a real-time monitorization of the KPI. This paper follows the methodology explained below. A cost model has been used to accurately develop this indicator together with the Six Big Losses description. At the same time, the machine tool has been integrated into a CPS, enhancing the real-time data acquisition, using the Industry 4.0 technologies. Once the KPI has been defined, we have developed the software that can turn these real-time data into relevant information (using Python) through the calculation of our indicator. Finally, we have carried out a case of study showing our new KPI results and comparing them to other indicators related with the Six Big Losses but in different dimensions. As a result, our research quantifies economically the Six Big Losses, enhances the detection of the bigger ones to improve them, and enlightens the importance of paying attention to different dimensions, mainly, the productive, sustainable, and economic at the same time.
Quantitative Analysis of 18 Marker Components in the Traditional Korean Medicine, Cheongsangbangpung-Tang, Using High-Performance Liquid Chromatography Combined with Photodiode Array Detector
Authors: Seo Chang-Seob , Shin Hyeun-Kyoo
Published: December 2020

Cheongsangbangpung-tang (CSBPT) is a traditional herbal medicine that has been used in many regions of Asia, including Korea, China, and Japan, for the treatment of purulent inflammation and eczema on the face. In this study, a method for the simultaneous analysis of 18 marker components, geniposide (1), coptisine chloride (2), prim-O-glucosylcimifugin (3), berberine chloride (4), liquiritin apioside (5), liquiritin (6), ferulic acid (7), narirutin (8), 5-O-methylvisammisoide (9), hesperidin (10), arctigenin (11), baicalin (12), oxypeucedanin hydrate (13), wogonoside (14), baicalein (15), arctiin (16), glycyrrhizin (17), and pulegone (18), was developed for quality control of CSBPT. The novel approach, which is based on high-performance liquid chromatography (HPLC) separation coupled with photodiode array detection, was verified by the assessment of linearity, limit of detection, limit of quantification, accuracy, recovery, and precision. Analysis of CSBPT by using the established assay revealed that compounds 1–18 were present in concentrations of 0.27–18.31 mg/g.
Time Series Analysis Applied to EEG Shows Increased Global Connectivity during Motor Activation Detected in PD Patients Compared to Controls
Authors: Maitín Ana María , Perezzan Ramiro , Herráez-Aguilar Diego , Serrano José Ignacio , Del Castillo María Dolores , Arroyo Aida , Andreo Jorge , Romero Juan Pablo
Published: December 2020

Background: Brain connectivity has shown to be a key characteristic in the study of both Parkinson’s Disease (PD) and the response of the patients to the dopaminergic medication. Time series analysis has been used here for the first time to study brain connectivity changes during motor activation in PD. Methods: A 64-channel EEG signal was registered during unilateral motor activation and resting-state in 6 non-demented PD patients before and after the administration of levodopa and in 6 matched healthy controls. Spectral entropy correlation, coherence, and interhemispheric divergence differences among PD patients and controls were analyzed under the assumption of stationarity of the time series. Results: During the motor activation test, PD patients showed an increased correlation coefficient (both hands p < 0.001) and a remarkable increase in coherence in all frequency range compared to the generalized reduction observed in controls (both hands p < 0.001). The Kullback­–Leibler Divergence (KLD) of the Spectral Entropy between brain hemispheres was observed to increase in controls (right hand p = 0.01; left hand p = 0.015) and to decrease in PD patients (right hand p = 0.02; left hand p = 0.002) with motor activation. Conclusions: Our results suggest that the oscillatory activity of the different cortex areas within healthy brains is relatively independent of the rest. PD brains exhibit a stronger connectivity which grows during motor activation. The levodopa mitigates this anomalous performance.
Spatial Structure and Activity of Synthetic Fragments of Lynx1 and of Nicotinic Receptor Loop C Models
Authors: Mineev Konstantin S. , Kryukova Elena V. , Kasheverov Igor E. , Egorova Natalia S. , Zhmak Maxim N. , Ivanov Igor A. , Senko Dmitry A. , Feofanov Alexey V. , Ignatova Anastasia A. , Arseniev Alexander S. , Utkin Yuri N. , Tsetlin Victor I.
Published: December 2020

Lynx1, membrane-bound protein co-localized with the nicotinic acetylcholine receptors (nAChRs) and regulates their function, is a three-finger protein (TFP) made of three β-structural loops, similarly to snake venom α-neurotoxin TFPs. Since the central loop II of α-neurotoxins is involved in binding to nAChRs, we have recently synthesized the fragments of Lynx1 central loop, including those with the disulfide between Cys residues introduced at N- and C-termini, some of them inhibiting muscle-type nAChR similarly to the whole-size water-soluble Lynx1 (ws-Lynx1). Literature shows that the main fragment interacting with TFPs is the C-loop of both nAChRs and acetylcholine binding proteins (AChBPs) while some ligand-binding capacity is preserved by analogs of this loop, for example, by high-affinity peptide HAP. Here we analyzed the structural organization of these peptide models of ligands and receptors and its role in binding. Thus, fragments of Lynx1 loop II, loop C from the Lymnaea stagnalis AChBP and HAP were synthesized in linear and Cys-cyclized forms and structurally (CD and NMR) and functionally (radioligand assay on Torpedo nAChR) characterized. Connecting the C- and N-termini by disulfide in the ws-Lynx1 fragment stabilized its conformation which became similar to the loop II within the 1H-NMR structure of ws-Lynx1, the activity being higher than for starting linear fragment but lower than for peptide with free cysteines. Introduced disulfides did not considerably change the structure of HAP and of loop C fragments, the former preserving high affinity for α-bungarotoxin, while, surprisingly, no binding was detected with loop C and its analogs.
Molecules, Mechanisms, and Disorders of Self-Domestication: Keys for Understanding Emotional and Social Communication from an Evolutionary Perspective
Authors: Šimić Goran , Vukić Vana , Kopić Janja , Krsnik Željka , Hof Patrick R.
Published: December 2020

The neural crest hypothesis states that the phenotypic features of the domestication syndrome are due to a reduced number or disruption of neural crest cells (NCCs) migration, as these cells differentiate at their final destinations and proliferate into different tissues whose activity is reduced by domestication. Comparing the phenotypic characteristics of modern and prehistoric man, it is clear that during their recent evolutionary past, humans also went through a process of self-domestication with a simultaneous prolongation of the period of socialization. This has led to the development of social abilities and skills, especially language, as well as neoteny. Disorders of neural crest cell development and migration lead to many different conditions such as Waardenburg syndrome, Hirschsprung disease, fetal alcohol syndrome, DiGeorge and Treacher-Collins syndrome, for which the mechanisms are already relatively well-known. However, for others, such as Williams-Beuren syndrome and schizophrenia that have the characteristics of hyperdomestication, and autism spectrum disorders, and 7dupASD syndrome that have the characteristics of hypodomestication, much less is known. Thus, deciphering the biological determinants of disordered self-domestication has great potential for elucidating the normal and disturbed ontogenesis of humans, as well as for the understanding of evolution of mammals in general.
Highly Active CO2 Fixation into Cyclic Carbonates Catalyzed by Tetranuclear Aluminum Benzodiimidazole-Diylidene Adducts
Authors: Mesías-Salazar Ángela , Yepes Yersica Rios , Martínez Javier , Rojas René S.
Published: December 2020

A set of tetranuclear alkyl aluminum adducts 1 and 2 supported by benzodiimidazole-diylidene ligands L1, N,N’-(1,5-diisopropylbenzodiimidazole-2,6-diylidene)bis(propan-2-amine), and L2, N,N’-(1,5-dicyclohexyl-benzodiimidazole-2,6-diylidene)dicyclohexanamine were synthetized in exceptional yields and characterized by spectroscopic methods. These compounds were studied as catalysts for cyclic carbonate formation (3a–o) from their corresponding terminal epoxides (2a–o) and carbon dioxide utilizing tetrabutylammonium iodide as a nucleophile in the absence of a solvent. The experiments were carried out at 70 °C and 1 bar CO2 pressure for 24 h and adduct 1 was the most efficient catalyst for the synthesis of a large variety of monosubstituted cyclic carbonates with excellent conversions and yields.
Broadband Microstrip Antenna for 5G Wireless Systems Operating at 28 GHz
Authors: Przesmycki Rafal , Bugaj Marek , Nowosielski Leszek
Published: December 2020

Communication systems have been driven towards the fifth generation (5G) due to the demands of compact, high speed, and large bandwidth systems. These types of radio communication systems require new and more efficient antenna designs. This article presents a new design solution of a broadband microstrip antenna intended for use in 5G systems. The proposed antenna has a central operating frequency of 28 GHz and can be used in the LMDS (local multipoint distribution service) frequency band. The dimensions of the antenna and its parameters have been calculated, simulated, and optimized using the FEKO software. The antenna has a compact structure with dimensions (6.2 × 8.4 × 1.57) mm. Rogers RT Duroid 5880 material was used as a substrate for the antenna construction, which has a dielectric coefficient of 2.2 and a thickness of 1.57 mm. The antenna described in the article is characterized by a low reflection coefficient of −22.51 dB, a high energy gain value of 3.6 dBi, a wide operating band of 5.57 GHz (19.89%), and high energy efficiency.
Photovoltaic Self-Consumption in Industrial Cooling and Refrigeration
Authors: Martínez-Calahorro Antonio Javier , Jiménez-Castillo Gabino , Rus-Casas Catalina , Gómez-Vidal Pedro , Muñoz-Rodríguez Francisco José
Published: December 2020

The industrial sector has a great opportunity to reduce its energy costs through distributed generation. In this sense, the potential of photovoltaic self-consumption systems in the industrial cooling and refrigeration sector is shown. Two industries with photovoltaic self-consumption installations are shown and the electricity consumption profile of this type of industry which has a remarkable basal electricity consumption during daytime is analyzed. The matching between consumption and photovoltaic generation profiles is provided through the self-consumption and self-sufficiency curves considering different reporting periods (monthly and annual). Moreover, a new index is presented: self-sufficiency index for sunshine hours, φSS,SH. This index evaluates the performance of the photovoltaic self-consumption system when facing the consumption only during sunshine hours. This index may complement the self-sufficiency index and may improve the analysis of this type of systems in the industrial sector. Self-consumption indices of 90% may be provided. Moreover, self-sufficiency indices for total (24 h) and for sunshine hours of 25% and 50%, respectively, for industry A, and 26% and 45% for industry B have been obtained. During daytime, half the load consumption in this type of industry may be covered by photovoltaics while achieving high levels of use of the photovoltaic energy generated.
Predicting the Response of High Frequency Spinal Cord Stimulation in Patients with Failed Back Surgery Syndrome: A Retrospective Study with Machine Learning Techniques
Authors: Goudman Lisa , Van Buyten Jean-Pierre , De Smedt Ann , Smet Iris , Devos Marieke , Jerjir Ali , Moens Maarten
Published: December 2020

Despite the proven clinical value of spinal cord stimulation (SCS) for patients with failed back surgery syndrome (FBSS), factors related to a successful SCS outcome are not yet clearly understood. This study aimed to predict responders for high frequency SCS at 10 kHz (HF-10). Data before implantation and the last available data was extracted for 119 FBSS patients treated with HF-10 SCS. Correlations, logistic regression, linear discriminant analysis, classification and regression trees, random forest, bagging, and boosting were applied. Based on feature selection, trial pain relief, predominant pain location, and the number of previous surgeries were relevant factors for predicting pain relief. To predict responders with 50% pain relief, 58.33% accuracy was obtained with boosting, random forest and bagging. For predicting responders with 30% pain relief, 70.83% accuracy was obtained using logistic regression, linear discriminant analysis, boosting, and classification trees. For predicting pain medication decrease, accuracies above 80% were obtained using logistic regression and linear discriminant analysis. Several machine learning techniques were able to predict responders to HF-10 SCS with an acceptable accuracy. However, none of the techniques revealed a high accuracy. The inconsistent results regarding predictive factors in literature, combined with acceptable accuracy of the currently obtained models, might suggest that routinely collected baseline parameters from clinical practice are not sufficient to consistently predict the SCS response with a high accuracy in the long-term.
Reconstructive Approaches in Surgical Management of Congenital Pseudarthrosis of the Tibia
Authors: Laufer Andrea , Frommer Adrien , Gosheger Georg , Roedl Robert , Schiedel Frank , Broeking Jan Niklas , Toporowski Gregor , Rachbauer Anna , Antfang Carina , Vogt Bjoern
Published: December 2020

Treatment of congenital pseudarthrosis of the tibia remains a major challenge in pediatric orthopedics. Ideal timing and preference of surgical procedures are discussed controversially. A variety of reconstructive treatment strategies have been described in literature, but so far none has proven its superiority. The aim of treatment is to obtain long-term bone union, to prevent refracture, and to correct angular deformities and leg length discrepancies. This study retrospectively evaluates the outcome of different reconstructive strategies. Sixty-nine patients were identified who presented to our outpatient department between 1997 and 2019. Twenty-six of these patients underwent reconstructive surgical treatment and were included in this study. The study cohort was divided into three groups. Excision of the pseudarthrosis was performed in all patients in Group A and B, and in two patients of Group C. Group A (six/26 patients) received subsequent bone transport through external fixation maintaining original length. In Group B (15/26 patients), patients underwent either previous, simultaneous, or subsequent extrafocal lengthening through external fixation to reconstitute length. In Group C (five/26 patients), internal fixation with intramedullary nails was applied. Radiological and clinical evaluation was performed to assess bone union and complication rates. Results varied considerably between the study groups. Overall, the primary bone fusion rate was 69.2%. There were four refractures, all occurring in Group B. The long-term bone union rate without refracture was 53.8%. The overall complication rate was 53.8% and 23.1% showed persistent pseudarthrosis. Two secondary amputations were performed due to failed bone fusion. In conclusion, excision of the pseudarthrosis and extrafocal lengthening achieves a satisfying bone union rate and limb reconstruction, while bone transport does not offer significant advantages but shows higher complication rates. Intramedullary stabilization should be applied to maintain bone union, but shows lower bone union rates when used as a stand-alone treatment regimen. Regardless of the primary bone fusion rates, the probability of long-term bone union remains unpredictable.
Da boca suja à mente poluída: a carta de Cícero a Peto (Ad Fam. 9.22)
Authors: Dezotti Lucas
Published: December 2020

Este trabalho apresenta uma tradução anotada da carta de Cícero a Lúcio Papínio Peto (Ad Fam. IX, 22). Nela Cícero disserta sobre a natureza e a origem da obscenidade expressa pela linguagem, recorrendo a exemplos práticos para demonstrar que o caráter obsceno de qualquer expressão linguística não se deve nem à natureza da coisa referida, nem à natureza da palavra pronunciada, e sim à atitude interpretativa do ouvinte. A tradução foi feita a partir do texto latino editado por Shackleton-Bailey (1977), acompanhado de notas explicativas para os exemplos utilizados por Cícero.
Mehmet Rauf’un “Halâs” Adlı Romanında İşgal ve Direniş
Authors: ŞENER Merve
Published: December 2020

Mehmet Rauf’un çalışmaya konu olan Halâs (1929) adlı romanı, Türk halkının Mütareke ve Milli Mücadele yıllarındaki işgaller karşısında gösterdiği direnişi konu edinir. Eser kurgusunda, romanın baş karakteri Nihat’ın yaşadığı olayların paralelinde; İzmir ve İstanbul’un işgali, Erzurum ve Sivas Kongreleri’nin gerçekleşmesi, düzenli ordunun kuruluşu, Urfa, Maraş ve Antep şehirlerinin düşman işgalinden kurtulması, Sevr Antlaşması’nın İstanbul Hükümeti tarafından kabul edilişi ve Ankara’da yeni bir hükümetin kuruluşu, kronolojik bir sırayla yer almaktadır. Mehmet Rauf, Anadolu’daki direnişi ve kurtuluş öyküsünü Nihat karakteri üzerinden hikâyeleştirmiştir. Bu çalışma kapsamında Halâs adlı eser, işgal ve direniş açısından incelenmiştir. Türk tarihinin önemli dönemeçlerinden biri olarak kabul edilen Millî Mücadele dönemini anlatma meselesine bir sorumluluk duygusu ile yaklaşan Mehmet Rauf, eserini tarihsel gerçeklere dayandırarak ele almıştır. Bu bakımdan, çalışmada, edebi bir eserin tarihî gerçekliği ne derece yansıttığına, eserden yapılan alıntılarla dikkat çekilmiştir.
Çorum Ağzındaki Eskicil Söz Varlığından Örnekler
Authors: ÖLMEZ Zühal , DEĞER Nermin
Published: December 2020

1932’den itibaren başlayan Anadolu Ağızlarındaki söz varlığının kayıt altına alınması çalışmaları, 1963’ten itibaren Derleme Sözlüğü’nün yayımlanma sürecinin başlamasıyla büyük bir gelişme kaydetmiştir. Bunun yanı sıra her bölgeden, ilden, ilçeden, köyden derlenen malzemeye dayanan yeni çalışmalarla Anadolu ağızlarındaki zengin söz varlığı ortaya çıkarılmış ve çıkarılmaya devam etmektedir. Ağızlardaki söz varlığı Tarihi Türk dillerindeki eskicil sözcüklerin korunması itibariyle de ayrı bir önem arz etmektedir. Bu tür sözcüklerin bir kısmı Türkiye Türkçesinde de kimi ses değişikleriyle yaşamaktadır. Bu eskicil sözcüklerin Anadolu ağızlarında eski biçimiyle aynı anlamda yaşadığı ya da anlam genişlemesi, anlam daralması vb. durumlara uğrayarak günümüze kadar ulaştığı görülmektedir. Bu çalışmada Çorum Ağzındaki eskicil (arkaik) sözcükler belirlenmeye çalışılmış ve yaklaşık 350 civarında eskicil sözcük tespit edilmiştir. Makale çerçevesinde tüm sözcüklerin değerlendirilmesi mümkün olmadığından kısaca söz varlığı üzerinde durularak bugün ölçünlü dilde ya da yazı dilinde kullanılmayıp Çorum ve yakın çevre ağızlarında yaşayan, Anadolu ağızlarında çok yaygın olmayan on sözcüğün (belinlemek, bahanak, danlamak, gelengi, goynumek, günülemek, kağşamak, örklemek, süsmek, yumuş) köken bilgisi üzerinde durulacaktır. Türk dilinin en eski evrelerinden yola çıkılarak tarihî dönemler içerisinde sözcüklerin geçirdiği değişimler ele alınacaktır. Tespit edilen sözcüklerin yapı ve anlam bakımından eskicilliği belirtilerek, Türkçenin tarihi dönemleri ile karşılaştırılarak sözcüklerin bu evrelerdeki kullanım şekilleri ortaya konulacaktır.
A pénzügyi rendszer ellenállóképessége mindenekfelett – de milyen áron?
Authors: Friesz Melinda
Published: December 2020

A tanulmány célja bemutatni a központi szerződő felek piacon betöltött szerepének fontosságát, kockázatkezelési keretrendszerét, beleértve a garanciaalapok elégtelensége esetén alkalmazandó eszközöket is. Az elemzés leíró, ismertető jellegű, amely az EU-ban működő központi szerződő felek szabályozói keretrendszerének bemutatása mellett, annak lehetséges hátulütőit is szemlélteti a piac és a szakemberek szemszögéből egyaránt. A tanulmány rámutat arra, hogy minden szereplő közös célja és érdeke egyaránt a központi szerződő fél lábontartása, de a nem megfelelően kialakított tőkekezelés és stratégia gátolhatja ennek megvalósulását. Bár a jogszabályi keretrendszer alkalmazása Európa-szerte megtörtént, finomhangolásuk pedig állandónak mondható, azok hatékonyságát és sokk-ellenállóképességét egy, a piacon bekövetkező komoly negatív esemény fogja alátámasztani vagy megcáfolni.
A digitális szolgáltatási adó szimbolikus jelentősége és annak gyakorlati következményei
Authors: Rigó Csaba Balázs , Tóth András
Published: December 2020

A digitális szolgáltatásokat kínáló világcégek jellemzően úgy nőttek nagyra, hogy a közterhek viseléséhez nem feltétlenül járulnak hozzá abban az országban, ahonnan a bevételeik megteremtéséhez szükséges adatvagyon származik. Jelen tanulmány célja annak bemutatása, hogy a digitális szolgáltatást nyújtó világcégek megadóztatása nem csak adóbevétel-növelési, de szimbolikus szempontból is jelentőséggel bír. Az "új olajat" jelentő adatok kiaknázásából ezért méltányosan részesednie kellene azon államoknak is, amelyek polgárainak adatai felhasználásával a digitális világcégek jelentős bevételre tesznek szert. A politikai, jogszabályi környezet elemzése és az állambölcseleti elméletek áttekintése révén arra jutottunk, hogy ebben a szimbolikájában is jelentős kérdésben sem valószínű az EU-szintű egységes fellépés sikere és éppen ezért tagállami, nemzeti szintű intézkedésekre lehet szükség.
Pensando y actuando en red. Análisis del hashtag #QuédateEnCasa en México
Authors: Olmedo Neri Raul Anthony
Published: December 2020

El contexto generado por la pandemia de la COVID-19 ha implicado que los gobiernos de cada Estado-Nación elaboren estrategias de comunicación en el espacio virtual para mantener a la población informada sobre el estado sanitario de cada país, así como de las medidas respectivas para su contención. En este sentido, el hashtag #QuédateEnCasa forma parte de la estrategia comunicativa del gobierno mexicano para diseminar información oficial en la sociedad sobre el impacto de este reto epidemiológico. Por ello, el presente trabajo aborda esta forma institucional de comunicación bajo el Análisis de Redes Sociales (Ars) con la finalidad de identificar la red que subyace en este hashtag, así como aquellos perfiles (nodos) que dentro de ese entramado de interacciones se han posicionado dentro del flujo de información a partir de la cantidad de vínculos que poseen, de su capacidad de diseminar la información, así como el nivel de cohesión que se ha generado en dicha red.
Agir sur soi pour agir sur autrui
Authors: Servais Véronique
Published: December 2020

Marinelands are entertainment companies whose main stars are marine mammals. Based on fieldwork conducted in a European aquatic park, this paper analyses how such a company deals with the many affects and emotions that intersect there: the dolphins’, the public’s, the trainers’ and the anti-captivity activists’. The first part of the paper shows that parks are engaged in a deliberate policy of affects that is used to legitimate captivity, in an international context that is globally unfavourable to it. The second part deals with trainers’ interactions with dolphins and document the affective work that trainers operate on themselves and on their animals in order to «produce» a dolphin that is eager to work and which they can trust.
Written Source of al-Muwaṭṭa: Risālat al-Farā’iḍ
Authors: KOÇİNKAĞ Mansur
Published: December 2020

Significant studies have been conducted on the origins and develop-ment of Islamic law in the past years. However, in regard to the first century AH, a lack of solid identified references has raised doubts around the accuracy of the reported facts during this period. For this reason, we explored a new reliable document referred to as Risālat al-Farā’iḍ, from the first century. It is accepted that this work was first written by Zayd b. Thābit (d. 45/665) and then annotated by Abū al-Zinād (d. 130/748) who lived during both the first and second centuries. In this study, it will be determined that based on the similarity between al-Muwaṭṭa’ and Risālat al-Farā’iḍ in nearly thirty-five paragraphs, Risālat al-Farā’iḍ has served as a source in the writing process of al-Muwaṭṭa’, besides, it has revealed consistent information about ʻamal (practice) of ahl al-Medīna. Finally, through this document analysis, it will be revealed that the claim that the basic hadith collections are based not only on the oral narrations but also on the written documents will be more accurate.