bluuebunny/crossref_metadata_2025 huggingface dataset:
producción científica comunicada en la Universidad Nacional de San Juan: indicadores para (re)conocer su diversidad.
Authors: Castillo Gonzalo Miguel
Published: January 2023

La comunicación de producciones científicas desarrolladas en Universidades se ha consolidado como una dimensión significativa de la circulación del conocimiento. En efecto, la publicación de artículos en revistas científicas con referato, junto a las actividades de comunicación pública del conocimiento desplegadas por académicos/as han ganado notoriedad en los debates académicos latinoamericanos actuales. Este trabajo, específicamente, focaliza en tales actividades desplegadas por docentes-investigadores/as de la Universidad Nacional de San Juan (UNSJ- Argentina) durante el año 2019. Su arquitectura metodológica se sostiene sobre la instrumentación de un conjunto específico de indicadores del “Manual de Cuyo: Indicadores Institucionales de Circulación del Conocimiento”, desarrollado por el Centro de Estudios de la Circulación del Conocimiento Científico (CECIC) y puesto a prueba en una serie de Universidades argentinas. Se trata de una herramienta de tecnología social orientada a (re)conocer las diferentes modalidades de interacción multiescalar del conocimiento producido en instituciones universitarias. Entre sus fuentes de información principales se abordaron: bases indexadoras de artículos científicos latinoamericanas y euroamericanas, memorias institucionales de la UNSJ junto a sus portales web institucionales de Rectorado y sus Unidades Académicas. Acerca de los resultados más significativos puede señalarse cómo la circulación de artículos científicos en bases indexadoras mainstream o regionales asume un peso diferencial según la procedencia disciplinar de sus autores. Por su parte, el grueso de las acciones de comunicación pública del conocimiento efectuadas por tales académicos/as tienden a materializarse, las más de las veces, hacia el interior de las instalaciones de la universidad en estudio.
Взаємозв’язки між показниками фізичної підготовленості та повсякденними адаптивними навичками у школярів з розладами аутичного спектра
Authors: Bodnar Ivanna , Petrusenko Oleksandra
Published: January 2023

Актуальність. Тенденція до збільшення кількості дітей із розладами аутичного спектра (РАС) та відсутність чітко встановлених методичних рекомендацій проведення фізичного виховання (ФВ) із такими дітьми актуалізують дослідження, які мають на меті покращити якість життя дітей із РАС засобами ФВ. Мета статті – встановити взаємозв’язки між показниками фізичної підготовленості й адаптивної поведінки дітей із РАС. Матеріали та методи. Учасниками дослідження були учні навчально-реабілітаційного центру І-ІІ ступенів «Довіра» 10-11 років з РАС: хлопці (n=19) і дівчата (n=5). Застосовували такі методи, як тестування фізичної підготовленості, спостереження за адаптивністю поведінки, методи математичної статистики (кореляційний аналіз). Тісноту взаємозв’язків між показниками фізичної підготовленості й адаптивності поведінки дітей установлювали за коефіцієнтом кореляції Браве-Пірсона. Для оцінювання ступеня адаптивності поведінки застосували рейтингову шкалу аутизму (Childhood Autism Rating Scale – CARS). Результати. Лише одна тестова вправа – стрибок у довжину з місця – утворювала зв’язок (r=–0,465, р<0,05) зі ступенем розладу адаптивності поведінки в дітей із РАС (сумою балів). Результат стрибка в довжину також виказував достовірні коефіцієнти кореляції ще з п’ятьма з 15-ти критеріїв адаптивності поведінки дітей із РАС. Результати виконання низки інших тестових вправ проявляли один-два достовірні кореляційні взаємозв’язки з показниками адаптивності поведінки дітей із РАС. Установили дані про погіршення окремих показників адаптивності поведінки дітей із покращенням результатів виконання ними окремих тестових вправ. Висновки. Підтверджено дані про те, що засоби ФВ можуть слугувати ефективним засобом корегування показників адаптивності поведінки дітей із РАС. Найбільш ефективними засобами ФВ, що позитивно позначаються на окремих показниках адаптивності поведінки дітей із РАС і загальному її рівні, можна вважати ті, що сприяють формуванню швидкості, швидкісної сили, координо­ваності рухів та здатності утримувати баланс. Суперечності, установлені нами, засвідчують, що питання зв’язку між фізичними вправами й повсякденними адаптивними навичками дітей із РАС потребує додаткового поглибленого вивчення.
ANALISIS ANGKA HARAPAN HIDUP, BELANJA MODAL DAN TPAK TERHADAP PENDUDUK MISKIN DI BIREUEN
Authors: Muammar Zikri , Usman Umaruddin , Anwar Khairil , Sari Cut Putri Mellita
Published: January 2023

ABSTRACTThis study examined the effect of life expectancy, capital expenditures, and labor forceparticipation rates on the poor in Bireuen during 2011-2020. This study used secondary data for 10 years. This study used the Autoregressive Distributed Lag (ARDL) analysis method. The results indicated that in the short and long term, life expectancy has a negative but insignificant effect on the poor, and capital expenditures and the level of labor force participation have a positive but insignificant effect on the poor in Bireuen.Keywords: Life Expectancy, Capital Expenditure, Labor Force Participation Rate, PoorPopulation, ARDL.
FAKTOR PSIKOLOGI KONSUMEN TERHADAP PENGAMBILAN KEPUTUSAN PERJALANAN BERWISATA MENGGUNAKAN APLIKASI PERJALANAN WISATA PADA SMARTPHONE
Authors: Asbar Yuli , Siregar Widyana Verawaty , Hafizh Hafizh
Published: January 2023

ABSTRACTThis study examined the influence of Consumer Psychological Factors on Decisions to Travel to Aceh Province Using Smartphones. This study used primary data obtained by distributing questionnaires to 120 respondents selected using the purposive sampling method. The data analysis method used was the multiple linear regression method with the help of SPSS. The results showed that smartphone selfefficacy had a positive and significant effect on Decisions to Travel to Aceh Province Using Smartphones, cellular-specific innovations had a positive but insignificant effect on Decisions toTravel to Aceh Province Using Smartphones. Mobile information privacy did not affect and had a negative and insignificant effect on Decisions to Travel to Aceh Province Using Smartphones,and personal attachment to a smartphone had a positive and significant effect onDecisions to Travel to Aceh Province Using Smartphones. Simultaneously, selfefficacy,cellular-specific innovation, information privacy, and attachment to smartphones had a positive and significant impact on Decisions to Travel to Aceh Province Using Smartphones. Keywords: Decision Making, Self-Efficacy, Cellular-special Innovation,Information Privacy, Personal Attachment to Smartphones,Decisions to Travel to Aceh Province Using Smartphones.
Jornalismo refém do algoritmo: qual o futuro da produção de notícias?
Authors:   , Moreno Ana Clara
Published: January 2023

A análise de dados consiste em captar certa quantidade de informações sobre determinado assunto e estudá-las com o objetivo de mapear e compreender o comportamento do público no ambiente digital. Nas redes sociais e em ferramentas de pesquisa, essa coleta e análise de dados é feita de modo constante e sistêmico, dado que são utilizados para alimentar algoritmos. Estes, por sua vez, são utilizados para ditar a experiência do usuário - construindo as timelines ou favorecendo certos resultados de pesquisa, com base em localização, perfil e inclinações ideológicas. Indo ao encontro dessas afirmações, tornou-se evidente com as recentes discussões legislativas e judiciais acerca do tema, o poder que tais ferramentas detêm - além de identificar padrões, inteligências artificiais e softwares programados, seja visando otimizar a experiência dos internautas, seja favorecendo determinada marca, partido ou organização. Deste modo, os algoritmos refletem incessantemente conteúdos considerados agradáveis ou semelhantes às características do perfil de seu usuário, comprometendo a entrega adequada do conteúdo publicado em rede e alterando um fluxo “neutro” de informações. Ao lado dessa consideração, cada dia mais palpável, o jornalismo, recém chegado no ciberespaço, se depara com muitos dilemas e estratégias digitais que se assemelham a camisas-de-força e colocam em cheque o exercício ético e influente da profissão. Mas, de fato, qual o impacto dos algoritmos no exercício do jornalismo digital?
A IMPORTÂNCIA DO SERVIÇO SOCIAL DENTRO DO SISTEMA PENITENCIÁRIO
Authors:   , Mesquita Neto Paulo de , Torres Andrea Almeida , Silvia Carmem
Published: January 2023

O desenvolvimento desse trabalho será realizado em forma de pesquisa bibliográficas, onde iniciar- á -se com um tópico introdutório, onde informações preliminares como justificativa, objetivos e a temática a ser estudada são informadas.
Em seguida as discussões serão ampliadas em dois capítulos sobre a importância do Serviço Social dentro dos sistemas penintenciários, abordando sobre o sistema peninteciário e as funções do assistente social dentro desse contexto. E finalmente as considerações finais reforçarão os tópicos previamente abordados, analisando se foram alcançados ou não.
UM CADERNO PARA AS IDEIAS DE UM JOVEM DO IF GOIANO QUE QUER MUDAR O MUNDO
Authors: Martins Daniel Valerio , Mesquita Ruan Rocha
Published: January 2023

Quem conta um conto acrescenta um ponto. Um caderno para as ideias de um jovem do IF Goiano que quer mudar o mundo, surge como uma avaliação materializada, a qual os estudantes levarão consigo para o resto de suas vidas em seus currículos enquanto autores da obra, além de ultrapassar fronteiras, por meio dos comentários desses professores. Assim, Joaquim terá´ suas ideias espalhadas pelo mundo de acordo com os sonhos do personagem. Essa avaliação foi gerada a partir da ideia de trabalho em grupo e cooperação em um conto giratório e colaborativo. Como base metodológica e teórica partimos de uma dinâmica criada pelo professor visitante chamada de O Pequeno Príncipe, inspirada na vida e obra de Antoine de Saint-Exupéry, interpretando frases dessa obra. Assim como o Pequeno Príncipe, Joaquim percebe que mudar o mundo sozinho se torna uma missão impossível, precisa de redes de apoio, de pessoas que pensem parecido, de corações que se encontram e se conectam por causas sociais, justas e humanitárias, pois “o essencial é invisível aos olhos”. Esperamos que a vida de Joaquim seja espelho como propõe Gandhi parafraseado nas linhas do segundo capítulo, e sirva de exemplo para jovens que ainda não se encontraram e lutam internamente na busca de quem sabe, ser um cidadão transformador no mundo, “superando as larvas que vão surgindo no caminho para ver as borboletas”.
bell hooks além do espelho
Authors: SILVA PATRICIA COSTA PEREIRA DA
Published: January 2023

“bell hooks além do espelho” é meu segundo e-book.

Para quem me segue há algum tempo, não é segredo que eu adoro bell hooks. Eu já li mais de 20 livros de sua autoria e sou encantada com sua honestidade intelectual e com seu pensamento heterodoxo, que a permitiu consultar referências de matrizes ideológicas diversas: de Santa Tereza D’Ávila a Nathaniel Branden, bell hooks ousou edificar a diversidade abraçando os diferentes.

Utilizando referências de obras de hooks, escrevi ensaios sobre liberdade, amor, religião, educação e masculinidades. Os 11 ensaios estão reunidos neste e-book.
Intervenção breve em Psicologia: práticas universitárias
Authors: Griggio Fabiana Nunes do Amarante
Published: January 2023

Buscou-se, portanto, ao organizar essa obra, apresentar, inspirar e, quiçá, instrumentalizar colegas psicólogos para a proposição de atividades similares, fomentando o papel da Psicologia na promoção do bem-estar e qualidade de vida da comunidade acadêmica. Desejamos a todos uma ótima leitura!
Saúde da Mulher - Edição VIII
Authors: MORAIS GLEICIANE INGRITH LINS DE
Published: January 2023

Dentre os diversos campos de conhecimento que englobam a área médica de saúde da mulher podemos destacar as abordagens ginecológicas, doenças autoimunes, hormonioterapia com seus riscos e benefícios, obstetrícia em seus assuntos mais delicados, os problemas psicológicos decorrentes de alterações fisiológicas ou ambientais. Pensando nisso, o corpo editorial da Editora Pasteur selecionou um conjunto de capítulos escritos com excelência sobre os temas supracitados. Com objetivo de disponibilizar maior conhecimento ao leitor e aumento da discussão sobre temas peculiares dessas pacientes tão especiais. Esperamos que a leitura seja agradável e instrutiva.
¿Qué es y qué no es trabajo infantil? Abordajes reflexivos desde un estudio de caso en el nordeste argentino
Authors: Miño María Gabriela
Published: January 2023

El objetivo principal del artículo fue lograr un aporte a las discusiones actuales sobre la delimitación de la problemática del trabajo infantil. Desde un estudio de caso realizado en el nordeste de Argentina, se retomaron los siguientes ejes de discusión: 1) las principales perspectivas actuales de abordaje sobre el tema, 2) la delimitación de la problemática por parte de la administración pública y referentes de Organizaciones No Gubernamentales, y 3) las repercusiones de la aplicación práctica de la delimitación del problema en las actuaciones de prevención. El estudio se enmarca en una investigación de tipo cualitativa, exploratoria y descriptiva, realizada en la provincia de Misiones, durante los años 2020-2022. Los principales resultados del estudio sugieren una caracterización del trabajo infantil ligada a la construcción de una tipología de familia en riesgo y la necesidad de ampliar las perspectivas de abordaje para una mayor comprensión de la problemática de estudio.
Tramas para tejer una educación no sexista. Apuntes sobre las luchas feministas en las universidades chilenas
Authors: Duarte Hidalgo Cory , Rodríguez Venegas Viviana
Published: January 2023

En mayo de 2018 se produjo un tsunami feminista en las universidades chilenas. Movilizaciones masivas y extensas surgieron como respuesta a la violencia en las instituciones de Educación Superior, impulsando un cambio paradigmático en el sistema educacional y científico del país. Para dar cuenta de esto, se realiza una investigación que mezcla la participación-observante –como herramienta metodológica feminista– con una revisión documental a partir de lo publicado sobre este tema en particular. Sus principales resultados versan sobre la trama sociopolítica y coyuntural de las luchas feministas en las universidades y la posibilidad de construir una educación feminista que fortalezca la convivencia democrática. Finalmente, en el contexto pospandémico, se hace urgente consolidar propuestas y acciones que permitan construir otras formas de relación en escenarios horizontales, colectivos y afectivos, como oposición a la violencia machista presente en las instituciones.
Asociación entre distorsiones cognitivas y estrés laboral en profesionales de la salud pública
Authors: Soria Reinozo Jenny Katherine , Noroña Salcedo Darwin Raúl
Published: January 2023

La presente investigación tiene como objetivo determinar la asociación entre distorsiones cognitivas y estrés laboral en el personal de salud pública. El estudio tomó un enfoque cuantitativo de tipo no experimental y transversal de alcance descriptivo-correlacional. Se aplicó el Inventario de Pensamientos Automáticos (IPA) de Ruiz y Luján (1991); y el Cuestionario para la evaluación del estrés construido por Villalobos (2010), citado por el Ministerio de la Protección Social (MPS, 2010), a un total de 92 profesionales del campo de la salud pública. Se llevaron a cabo tres tipos de análisis: descriptivo, inferencial y de asociación. Se obtuvieron frecuencias, porcentajes y medidas de tendencia central en donde se aplicó el Chi cuadrado para establecer las relaciones estadísticamente significativas con un nivel de significancia del .05. Finalmente se utilizó el Odds Ratio (OR) para determinar la probabilidad de ocurrencia. Como principales resultados se obtuvieron 24 relaciones estadísticamente significativas con las 15 distorsiones cognitivas relacionados con 3 de las 4 dimensiones del estrés laboral, todos ellos cumpliendo con un nivel de P<.05, con una intensidad que se puntuó entre media y alta. Se concluye que todos los pensamientos automáticos tuvieron relación significativa con el aparecimiento de estrés laboral en las dimensiones de síntomas fisiológicos, de comportamiento social e intelectuales y laborales.
Pengaruh Latihan V Roll Terhadap Akurasi Passing
Authors:   Pendidikan Jasmani Kesehatan dan Rekreasi, FKIP Universitas Negeri Singaperbangsa Karawang, Hadi Aditya Muhammad , Abduloh Abduloh ,   Pendidikan Jasmani Kesehatan dan Rekreasi, FKIP Universitas Negeri Singaperbangsa Karawang, Kusuma Yuda Aria ,   Pendidikan Jasmani Kesehatan dan Rekreasi, FKIP Universitas Negeri Singaperbangsa Karawang
Published: January 2023

This study aims to examine the effect of v roll training on the accuracy of passing futsal in the extracurriculars of SMAN 13 Depok. The subjects of this study were futsal extracurricular students at SMAN 13 Depok. In this study, the total population was 25 extracurricular players at SMAN 13 Depok. The sample in this study was 25 people using total sampling. With 10 meetings 2 of them pretest and posttest to measure the initial test and final test. In carrying out the initial test, the pretest score was obtained with a total score of 111 and the posttest with a total score of 131. The results of this study indicate that the effect of v roll training on the accuracy of the inner leg futsal passing has increased with the resulting tcount being -4.178 at 24 more degrees of freedom greater than the ttable value of 2064 and with a sig. (2-tailed) of 0.000 > 0.05 so it can be concluded that there is a significant difference between the results of the v roll exercise on the accuracy of passing futsal in the inner leg in the pretest and posttest data. So that the v roll training approach has a significant impact on the passing accuracy of the inner leg futsal extracurricular at SMAN 13 Depok.
Changes in the immunological reactivity in patients with coxarthrosis and the factors that determine them
Authors: Dmitrieva L. A. , Pivovarov Yu. I. , Lebedev V. F.
Published: January 2023

Background. The participation of immune responses in the pathogenesis of degenerative-dystrophic diseases of the synovial joints determines the feasibility of using more rational approaches to assessing the immune status of patients with this pathology. Despite the ongoing immunological studies in patients with degenerative-dystrophic diseases of the hip joint, there are questions related to the functioning of the immune system as a whole, which require additional research.The aim of the study was to establish the features of the relationship between the indicators of the immune status and to identify the factors that determine the nature and severity of immunological disorders in patients with coxarthrosis.Material and methods. The study is based on the results of immunological parameters in 73 patients (mean age – 45.3 ± 2.56 years) with stage III dysplastic coxarthrosis. The data obtained using cluster analysis made it possible to distribute patients into two groups. The first clinical group included 46 patients, the second one – 27 patients. The control group consisted of 28 clinically healthy individuals. Mathematical processing of the results was carried out using the Statistica 6.0 software package (StatSoft Inc., USA) and the mathematical package Mathcad 2001 Pro (MathSoft Inc., USA).Results. The levels of CD4+ and CD8+ cells and IgA were determined as the classification features that make the greatest contribution to the division of the studied groups. Model experiments have shown that a specific combination of the magnitude of each of the noted factors with a certain degree of probability makes it possible to assess the state of the initial immunological reactivity and verify the nature and severity of immunological disorders.Conclusion. The information obtained is of great importance, since it allows predicting the course of the recovery period after surgery and assessing the risk of developing possible postoperative complications in patients with severe articular pathology.
Genotypic properties of collection plague microbes strains from the natural plague foci of Kazakhstan
Authors: Meka-Mechenko T. V. , Izbanova U. A. , Abdel Z. Zh. , Nakisbekov N. O. , Lukhnova L. Yu. , Baitursyn B. , Dalibayev Zh. S. , Umarova S. K.
Published: January 2023

Background. Epidemiological and epizootological monitoring of natural plague foci requires an integrated approach to solving problems, taking into account the phenotypic and genetic variability of Y. pestis and zoning of natural plague foci. The introduction of a new molecular genetic methodology aimed at studying the genomic polymorphism of the plague pathogen provides reliable results for the differentiation of not only groups, but also individual strains.The aim. To determine the genotypes of the plague microbe from different autonomous foci of the Republic of Kazakhstan.Materials and methods. 105 strains of Y. pestis isolated from various natural plague foci of Kazakhstan in 1951–2015 were studied. The phenotypic properties of the strains were studied using standard microbiological methods. A polymerase chain reaction (PCR) was used to detect fragments of the cafl, pst and YPO2088 genes. Multilocus variable number tandem repeat (VNTR) analysis (MLVA) was performed for 25 VNTR loci.Results. The phenotypic properties of the strains were preliminarily studied and the strains of the plague microbe were tested for specificity using the Pest-Quest test system (Kazakhstan). The PCR study confirmed the species-specific affiliation of Y. pestis strains. A variety of strains with typical phenotypic characteristics was revealed. MLVA for 25 key loci (MLVA25) revealed that the studied strains of the plague microbe are phylogenetically closest to the Mediaevalis biovar representatives. A phylogenetic tree of the studied strains has been obtained. It was found that 9 genotypes circulate on the territory of Kazakhstan, and their distribution in certain natural plague foci was determined.Conclusions. The resulting clustering indicates the relationship between the strain groups obtained on the dendrogram by the MLVA25 method and the territories of certain natural plague foci.
Factors of local conversion of iodothyronines correlate with indicators of hormonal, biochemical, and hematological profiles in patients with spinal canal and dural sac stenosis of the lumbar spine
Authors: Rodionova L. V. , Zhivotenko A. P. , Samoilova L. G. , Barkhatov D. A. , Pushkarev A. S. , Larionov S. N. , Potapov V. E. , Sorokovikov V. A.
Published: January 2023

In order to find out the mechanisms of pathogenesis of degenerative-dystrophic diseases of the spine, it is of particular interest to search for body parameters which are directly or indirectly interrelated with the key factors of peripheral conversion of nidus iodothyronines and constitute a system of network interactions, affecting metabolic indicators at the local and systemic level.The aim. To search for correlations of local key factors of peripheral conversion of Ligamentum flavum iodothyronines with indicators of biochemical, hematological and hormonal blood profiles of patients with stenosing processes of the spinal canal and dural sac in the lumbar spine.Materials and methods. 33 patients (15 males, 18 females) with stenosing processes of the spinal canal and dural sac in the lumbar spine were examined (mean age – 45.73 ± 1.95 years). The expression of deiodinase genes and other candidate genes was determined in Ligamentum flavum biopsies collected during surgical treatment. Biochemical, hematological and hormonal parameters were determined in peripheral blood. The resulting data array was processed in order to find correlations between the parameters of systemic and local metabolism.Results. The relationships of deiodinases with the expression of GDF5, MMP1, MMP3 and TIMP1 in Ligamentum flavum (p < 0.05) were found. Of the hormonal profile of the blood serum, the most significant indicators were thyreotropin, free triiodothyronine and thyroperoxidase antibodies. In the biochemical profile, levels of direct bilirubin, total cholesterol, HDL and LDL cholesterol and triglycerides changed along with the expression of deiodinases. Correlative relationships with the expression of deiodinases were found for the following hematological analytes of whole peripheral blood: hemoglobin, mean corpuscular hemoglobin concentration, numbers of granulocytes, lymphocytes, eosinophils, monocytes, band neutrophils, red cell distribution width and platelet crit. The data obtained indicate the involvement of peripheral conversion factors in the pathogenetic process and provide information to form a new view on the pathogenesis of degenerative-dystrophic processes in the Ligamentum flavum of patients with stenosing processes of the spinal canal and the dural sac in the lumbar spine.
The concept of comorbidity of dyscirculatory encephalopathy and vascular optical neuropathy (literature review)
Authors: Iureva T. N. , Zaika A. A.
Published: January 2023

The analysis of literature data on ischemic damage to the brain and the organ of vision was carried out in order to study etiological factors, pathogenetic processes, parallel flow and mutual influence of two nosological forms: dyscirculatory encephalopathy and vascular optic neuropathy. According to the World Health Organization, there is much more people suffering from cardiovascular diseases: atherosclerosis, hypertension, diabetes mellitus and coronary heart disease. These diseases result in ischemic damage to a number of vital organs, including the central nervous system and the visual analyzer. Chronic vascular pathology of both the brain and the eye is one of the leading causes of patients’ life quality decrease of and their disability. The “triggering” causes of brain and eye damage, according to researchers, are cerebral atherosclerosis, elevating/fluctuating blood pressure, coronary heart disease, and carbohydrate metabolism disorders. Disorders of the systemic blood supply caused by these etiological factors lead to a progressive lack of oxygen supply to organs and tissues, followed by the development of intracellular and cellular hypoxia, and an ischemic intracellular cascade of biochemical disorders leading to dysfunction and sometimes cell death.In addition to direct hypoxic-ischemic damage of the nervous and visual systems cells, endothelial dysfunction contributes to the progression of these diseases, leading to a pronounced change in the wall at the level of small vessels, a change in its reactivity and a violation of the coagulation properties of blood, and as a consequence, to a gradual accumulation of ischemic and secondary degenerative changes in brain and eye cells.Knowledge of etiological factors and patterns of development of brain and eye combined ischemic damage can allow clarifying the complex of diagnostic measures, developing preventive measures, as well as prescribe pathogenetically justified treatment of existing pathology.
Associations of genes of DNA repair systems with Parkinson’s disease
Authors: Babushkina N. P. , Nikitina M. A. , Bragina E. Yu. , Alifirova V. M. , Postrigan A. E. , Deviatkina Ye. A. , Gomboeva D. E. , Nazarenko M. S.
Published: January 2023

Background. Approximately 5–10 % of cases of Parkinson’s disease (PD) are monogenic, in other cases the pathology has a multifactorial etiology. One of recognized pathogenetic pathways of PD is mitochondrial dysfunction, in particular the accumulation of damage in mitochondrial DNA. Hence, the genes of DNA repair proteins are promising candidate genes for multifactorial forms of PD.The aim. To study the involvement of genes of DNA repair proteins in the development of Parkinson’s disease.Materials and methods. The associative analysis was carried out while comparing a group of patients with PD (n = 133) with a Tomsk population sample (n = 344). SNaPshot analysis was used to study 8 SNPs in genes of DNA repair proteins (rs560191 (TP53BP1); rs1805800 and rs709816 (NBN); rs473297 (MRE11A); rs1189037 and rs1801516 (ATM); rs1799977 (MLH1); rs1805321 (PMS2)).Results. Common alleles and homozygous rs1801516 genotypes in the ATM gene predispose the development of PD (odds ratio (OR) – 3.27 (p = 0.000004) and OR = 3.46 (p = 0.00008) for risk alleles and genotype respectively) and rs1799977 in the MLH1 gene (OR = 1.88 (p = 0.0004) and OR = 2.42 (p = 0.00007) respectively); heterozygotes have a protective effect (OR = 0.33 (p = 0.0007) and OR = 0.46 (p = 0.0007) for ATM and MLH1, respectively). The rare rs1805800 allele in the NBN gene (OR = 1.62 (p = 0.019)) and a homozygous genotype for it (OR = 2.28 (p = 0.016)) also predispose to PD. Associations with PD of the ATM, MLH1, NBN genes were revealed for the first time.Conclusion. Mitochondrial dysfunction is one of the key factors in the pathogenesis of PD, while at least two of the three protein products of associated genes are involved in the development of mitochondrial dysfunction. Accordingly, it can be assumed that associated genes are involved in the pathogenesis of PD precisely through mitochondrial dysfunction.
Cognitive status in older patients with limited mobility as a predictor of negative outcome
Authors: Tkacheva O. N. , Runikhina N. K. , Reshetova A. A. , Lysenkov S. N. , Cherdak M. A. , Mkhitaryan E. A. , Sandakov Ya. P. , Sharashkina N. V.
Published: January 2023

Background. Cognitive impairment (CI) is one of the important disability factors in the elderly. The role of CI in prognosis of the frailest patients with limited mobility is uncertain.The aim. To determine the influence of the initial cognitive status in the group of patronage patients aged 60 years and older on the risk of mortality within one year.Materials and methods. Study group consisted of 450 patients from patronage group with one-year period of observation (from July 2019 till July 2020). Initial physical, functional, neuropsychiatriac and social statuses were evaluated by comprehensive geriatric assessment. Cognitive impairment was screened by Mini-Mental State Examination (MMSE), with dividing patients into dementia group (MMSE ≤ 24) and no-dementia group (MMSE > 24). The mortality rate after one year was assessed.Results. Of the 450 patients included in the study, dementia was present in 44.2 %. Patients with dementia were more prone to greater severity of chronic pain, sleep disturbances, depression, malnutrition and anemia. After one year of observation 34 out of 196 patients (17.3 %) in the group of patients with dementia and 18 out of 248 patients (7.3 %; p = 0.002) in the no-dementia group died. According to multivariate analysis, independent risk factors for death in patients with dementia were anemia, hearing impairment and a history of bone fractures.Conclusion. Thus, the assessment of the cognitive status of frail patients with limited mobility is important for the purpose of identifying the most vulnerable individuals with a high risk of adverse outcomes.
Magnetic resonance imaging of subchondral insufficiency fractures in the knee (literature review)
Authors: Ivankov A. P. , Seliverstov P. V.
Published: January 2023

Stress fractures are an actual problem of modern medicine. A fracture associated with insufficiency of the bone tissue of the knee condyles is a new type of stress fracture that occurs in people aged 50–55 years in response to a normal daily activity, but with damage to the weakened subchondral bone tissue of the joint caused by various reasons. This literature review is mainly based on data from foreign medical sources, since there is very little information on this type of fracture in Russian sources. This is primarily due to the fact that initially the world and Russian medical communities designated this type of fracture as a spontaneous osteonecrosis of the knee (SONK). In recent years, this term has been revised abroad and replaced by a more suitable one – subchondral insufficiency fracture of the knee (SIF/SIFK). According to modern concepts, it is necessary to clearly distinguish among the concepts of osteonecrosis and subchondral insufficiency fracture of the knee. The reason for this is not only differences in the pathogenesis of these pathologies, but also fundamentally different approaches to managing these patients. Thus, taking into account the fundamental differences in the treatment of patients with stress fracture associated with bone insufficiency and patients with osteonecrosis, and also the relevance of stress fracture of the knee condyles, we state the following aim – to study the available literature on this problem.
Comparative analysis of the results of the anterior cruciate ligament reconstruction using an autograft preparation by known and new methods
Authors: Balzhinimaev D. B. , Mikhaylov I. N. , Puseva M. E. , Tishkov N. V.
Published: January 2023

Background. To date, the problem of choosing the optimal graft for anterior cruciate ligament (ACL) reconstruction and the methods for its formation is one of the main trends in the surgical treatment of patients with anterior knee joint instability.The aim. To compare the results of the anterior cruciate ligament reconstruction using the known method and the new proposed method for autograft formation.Materials and methods. The results of treatment of ACL injury in 44 patients were assessed. In the main group (19 patients), an original technique of ACL reconstruction from 1/2 of the width of m. peroneus longus tendon was used. In the control group (25 patients), ACL reconstruction was performed using a graft from the m. semitendinosus tendon prepared by the Lubowitz method.Results. The mean difference in the circumference of the distal third of the hip in the main group was 1.57 ± 1.162 cm and was statistically significantly better than in the control group, where the mean difference in the hip circumference was 4.74 ± 1.7207 cm.The range of motion of the knee joint in the main group 3 months after the surgery was 128.42 ± 9.287°, and in the control group mean flection was 109.6 ± 9.120°.The functional results in the main group were assessed by the Lisholm scale and were statistically significantly better than the results in the control group. The functional results by the AOFAS (American Orthopedic Foot & Ankle Society) scale in the main group were 100 points before the surgery and at all terms after the surgery: this indicates that the use of 1/2 of the width of m. peroneus longus tendon does not cause the its functional impairement.Conclusion. Anterior cruciate ligament plasty with use of 1/2 of the width of m. peroneus longus tendon prepared by the proposed method showed statistically significantly better results compared to the preparation of autograft from semitendinous muscle tendon using known method.
Assessment of the effectiveness of surgical treatment of patients with massive ruptures of rotator cuff tendons using latissimus dorsi tendon transposition
Authors: Menshova D. V. , Ponomarenko N. S. , Kuklin I. A. , Tishkov N. V. , Monastyrev V. V. , Pozdeeva N. A.
Published: January 2023

Rotator cuff ruptures are the most common injuries of shoulder joint with an incidence of about 20 %. This pathology is more common in adults over 60 years of age because it is caused by degenerative changes in the tendon. Massive injuries account for 10–40 % of all rotator cuff injuries. Currently, there is no unified surgical tactics for the treatment of patients with massive ruptures of rotator cuff tendons.The aim. To assess the efficiency of transposition of the latissimus dorsi tendon in patients with massive ruptures of the rotator cuff tendon.Materials and methods. The study included 15 patients with Patte stage III massive ruptures of the rotator cuff who had transposition of the latissimus dorsi tendon.Results. The article presents clinical cases of surgical treatment of patients. The following criteria were assessed: mean age; time since injury; duration of the surgery; blood loss volume; functional results by the ASES (American Shoulder and Elbow Surgeons) Shoulder Score. Taking into account the ASES Shoulder Score indicators 1 year after the surgical treatment, the following results were obtained: excellent results – in 9 (53.3 %) cases; good results – in 1 (13.4 %) case; satisfactory results – in 5 (33.3 %) cases.Conclusion. When preserving the articular cartilage, the method of choice in the treatment of patients with massive ruptures of rotator cuff tendons is transposition of the latissimus dorsi tendon. At the same time, an incomplete restoration of the function of the injured limb was registered in 33.3 % of patients, which requires further study and modification of the known method of transposition of the latissimus dorsi tendon.
Prognostic value of molecules of average mass in patients with chronic obstructive pulmonary disease
Authors: Prokofyeva T. V. , Polunina O. S. , Voronina L. P. , Polunina E. A. , Sevostyanova I. V.
Published: January 2023

Background. Chronic obstructive pulmonary disease is a socially significant disease affecting patient’s quality of life. Assessment of endogenous intoxication in patients with chronic obstructive pulmonary disease will allow to understand pathogenetic features of different phenotypes of this disease, which can be taken into account when predicting its course.The aim of the study. To determine the prognostic value of levels of mediumand low-molecular-weight substances and oligopeptides in patients with chronic obstructive pulmonary disease.Materials and methods. One hundred and four patients with chronic obstructive pulmonary disease (COPD) and 110 somatically healthy individuals were examined. Molecular weight medium and low molecular weight substances (LMWSM) and oligopeptides (OP) were determined in blood plasma, erythrocytes and urine. Based on these indicators mathematically calculated indices of endogenous intoxication and coefficient of elimination were defined. Statistical processing of the data was performed using the SPSS 26.0 software package (IBM Corp., USA).Results. In all biological fluids, the levels of average molecules and calculated indices in the COPD patients’ group were statistically significantly different from those in the control group. The indices characterizing endotoxin accumulation were statistically significantly higher, while those characterizing toxin elimination were lower. The level of endotoxemia was correlated with the frequency of exacerbations, clinical manifestations severity, quality of life, COPD group and phenotype.Conclusions. Frequent exacerbations, groups C and D, bronchitic and mixed COPD phenotypes are characterized by more severe endotoxicosis manifested by high levels of LMWSM, OP and calculated indices.
Genotypic and phenotypic characteristics of Mycobacterium tuberculosis drug resistance in TB children
Authors: Khromova P. A. , Zhdanova S. N. , Solovieva N. S. , Sinkov V. V. , Masharsky A. E. , Vyazovaya A. A. , Mokrousov I. V. , Rychkova L. V. , Kolesnikova L. I. , Zhuravlev V. Yu. , Ogarkov O. B.
Published: January 2023

Background. Russian Federation is included in the list of 30 countries with the highest burden of tuberculosis, including MDR tuberculosis. The most important part of this problem is the primary MDR/XDR TB in children.The aim: a comparative analysis of the phenotypic and genotypic profile of drug resistance to anti-tuberculosis drugs (ATP) according to whole genome sequencing of M. tuberculosis strains from children.Materials and methods. Whole genome sequencing (WGS) results of 61 M. tuberculosis isolates from children with tuberculosis in 2006–2020 in the Russian Federation were analyzed for anti-TB drug resistance mutations, according to the WHO catalog and were compared with the results of phenotypic drug sensitivity.Results. The M. tuberculosis belonged to two genetic groups: Beijing genotype – 82 % (50/61) dominant Central Asian Russian (31/50) and B0/W148 (16/50) subtypes, and non-Beijing (Ural, S, LAM) – 18 % (11/61). Three isolates belonged to Asian Ancestral subtype (3/50). Of the 61 isolates, only 14.7 % (9/61) were sensitive to antiTB drugs, 49.2 % (30/61) were MDR and 14.7 % (9/61) were pre-XDR. Comparison of the resistance profile (MDR/pre-XDR) with genotype revealed an upward shift for Beijing isolates, in particular Beijing B0/W148 (15/16) subline compared to other Beijing (19/34) (Chi-square with Yates correction = 5.535; p < 0.05) and nonBeijing (5/12) (Chi-square with Yates correction = 6.741; p < 0.05) subtypes. Discrepancies between genotypic and phenotypic drug resistance profiles were found in 11.5 % (7/61) of cases.Conclusions. Based on the analysis of WGS data, the genotypic characteristics of M. tuberculosis and the most complete set of drug resistance mutations were obtained, indicating a significant prevalence in MDR and pre-XDR TB of cases caused by epidemic subtypes of Beijing (B0/W148 and Central Asian Russian). The molecular mechanisms of adaptation of M. tuberculosis to the treatment of anti-TB drugs are not unique for the child population but reflect the general processes of the spread of MDR/XDR in Russia.
INSTITUTIONAL PRECONDITIONS AND GENESIS OF NATURAL GAS EXCHANGE TRADING
Authors: Kurbet Oleksandra
Published: January 2023

Natural gas is one of the world's leading sources of primary energy, and gas exchanges are key players in the natural gas market, which ensure its functioning on a liberal basis. Given the current liberalization trends, exchange trading in natural gas is gaining momentum and importance in this market. The main objective of the study was to determine the institutional preconditions and the main stages of the genesis of the exchange segment of natural gas trade. The study showed that gas exchanges and gas hubs are the key institutions of natural gas exchange trading, as they ensure openness and transparency of the market. As a result of the study, the author identified the following institutional prerequisites for the creation of gas exchanges: the need to form a competitive gas market and ensure its availability to third parties, ensuring transparent pricing and setting the market price for gas, simplification of trade procedures and standardization of products, protection of the execution of agreements and limitation of risks, which is manifested in the security and reliability of supplies and increasing the energy security of the state. Identifying the stages of the evolution of natural gas exchange trading, the author distinguished gas trading on mixed commodity exchanges, gas trading on universal and specialized energy exchanges, which began to emerge slowly in the 1990s, and gas market liberalization, accompanied by a boom in the creation of gas exchanges and gas hubs. The recession of 2008-2009, the shale gas revolution, the process of decarbonization of the economy and the full-scale invasion of Ukraine by Russia have been the main catalysts for the modern transformation of the natural gas market in recent decades. The author concludes that the latter will significantly affect the natural gas market in the coming years, which will lead to a revision of European policy in this area and the struggle for energy security. This paper is an original scientific study of the evolution of natural gas exchange trading and makes a certain contribution to the study of the peculiarities of the gas market functioning.
Kedudukan UU Cipta Kerja Terhadap UU-PPLH dan Implikasinya
Authors: Helmi Helmi -
Published: January 2023

Law of job creation (UU-CK)  already change, remove, and shift the new norm of law of environmental protection (UU-PPLH) in today  potentially to create a matter and second legal conflict for this law in the action and law enforcement in the future. Among the urgency of economic affair through the acceleration  of investment will face off the urgency of the protection  and environmental management. Both matters come as the focus on this article analysis here are these,  first the legislation as a system and implication  of job creation's law legality against UU-PPLH as environmental clustering in Indonesia. Second, the implication of the change of UU-PPLH due to UU-CK. Here is the conclusion, first the change of UU-PPLH's primary norm due to UU-CK will impact on another norm which the legality directly related on the protection and environmental management overall. Second, the implication identified from the content material, both law potentially to create a norm conflict on the action and law enforcement. Meanwhile, if this case related to the principle of legal conflict settlement, then no principle can be used either the principle of lex specialis derogat legi generalis, the principles of Lex superior derogat legi inferior, and the principles of lex posterior derogat legi priori. To encounter the norm conflict matter, the better one in reformating regulation in the way of Omnibus law method, despite it is limited on the system of clustering and organization, but also not repeal and state the illegality of the impacted regulation.
KEARIFAN LOKAL DI KABUPATEN KEPULAUAN MERANTI
Authors: Rasudin Nurahim
Published: January 2023

This study aims to identify local wisdom in the Meranti Islands Regency. The method used in this research is a juridical-normative research which focuses on library data research. The normative juridical approach, namely the method used by adhering to the juridical aspects, by carrying out an inventory of positive laws relating to the problems studied. Juridically, local governments have the authority to increase the capacity of local wisdom or traditional knowledge and the rights of local wisdom or traditional knowledge related to the environment in the regencies/cities. Local wisdom in Meranti Islands Regency, there are approximately 300 types of local wisdom. Of these, they can be grouped into 5 (five) major groups. Namely, local wisdom related to agriculture, local wisdom in the culinary field, local wisdom in the natural resource management sector (peat), local wisdom in the field of traditional games and sports, and local wisdom in the field of fisheries and marine affairs.
Comparative Analysis of Financial Distress Models in Predicting Bankruptcy during Covid-19 Pandemic
Authors: Hertina Dede , Dari Farida Wulan
Published: January 2023

This study aims to determine whether there is a difference between the financial distress models in predicting bankruptcy, and the most accurate financial distress models bankruptcy in construction and building companies listed on Indonesia’s Stock Exchange for the 2020-2021 period. The financial distress models used in this research are Springate, Taffler, and Zmijewski. The research population consisted of 18 companies and the sample was taken as many as 16 companies using purposive sampling method. The data research was collected from the company’s financial statement. This research uses a descriptive comparative method by conducting the Kruskal Wallis test to determine the difference between the Springate, Taffler, and Zmijewski. The results showed that there is a significant difference between the financial distress models in predicting bankruptcy predictions for the construction and building companies listed on Indonesia’s Stock Exchange for the 2020-2021 period. The most accurate model in bankruptcy prediction is the Taffler model with an accuracy rate of 100% and the error rate of 0%. Zmijewski has 81,25% of accuracy rate and 18,75% of error. Then the lowest accurate model in bankruptcy prediction is the Springate model with 12,50% of accuracy and 87,50% of error rate.