bluuebunny/crossref_metadata_2025 huggingface dataset:
Fatores que dificultam o diagnóstico precoce da Hanseníase no Brasil
Authors: Martins Henrique Santos de Sousa , Cruz Luís Fernando Carneiro da , Cavalcante Douglas Paraibano , Wanderley Débora de Santana Pio , Nascimento Letícia Oliveira Cassimiro Dias , Godoy Janine Silva Ribeiro
Published: December 2022

Introdução: A hanseníase é um problema de saúde pública, que quando não diagnosticada precocemente e tratada de forma adequada poderá evoluir e gerar incapacidades físicas aos seus portadores. Por conseguinte, o presente estudo tem como sua questão norteadora: “Quais são os fatores que dificultam o diagnóstico precoce da Hanseníase?”. Objetivo: Compreender, partindo da análise de trabalhos nacionais, quais são os fatores que entardecem o diagnóstico da Hanseníase no Brasil. Método: Trata-se de uma Revisão Integrativa, através da qual foram revisados artigos de estudos indexados nas bases de dados SCIELO e LILACS. Para tanto, foram utilizados os seguintes descritores: Hanseníase; Diagnóstico tardio; Diagnóstico e Dificuldade. Resultados e Discussão: Por meio da revisão de 6 artigos, publicados entre 2007 e 2019, foi possível concluir que a falha no diagnóstico precoce da hanseníase perpassa por fatores que vão desde a falta de treinamento das equipes de atenção primária, até questões habitacionais, sociais e de gênero. Conclusão: O diagnóstico tardio da hanseníase tem relação direta com o grau de incapacidade física gerado pela doença. Sendo assim, a ponderação frente aos fatores causais de tal atraso permite o aprimoramento e a correção de processos e estratégias utilizadas para interromper tanto a evolução da doença quanto a sua cadeia de transmissão.
Multilingual education development in Ukraine
Authors: Nikolska Nina , Pershukova Oksana
Published: December 2022

In a world that is becoming more globalized, learning a language is a crucial component of developing one's consciousness and their capacity for social mobility. Changes in the definition of the degree of foreign language proficiency, new definitions of the selection of content and organization of resources, and the employment of appropriate forms and methods of control are all necessary in response to new realities. In light of Common-European polymeric trends, our state's integration into the European educational space, the proliferation of student exchange practices, and the accessibility of our nation's educational system to international students, multilingual education on the principle of Ukrainian + foreign is of particular relevance. The expansion of foreign language learning is consistent with European directives, which advise that Member States teach two more EU languages in addition to their national tongue in educational institutions. The issue of linguistic and cultural diversity in Europe can be adequately addressed through multilingual education in Ukraine. The consideration of regional demands of local ethnic populations, national features, and Common European trends is a crucial aspect of multilingual education in Ukraine.
Ustavotvorčeva vizija socijalno pravednoga
poretka i zaštita dostojanstva i siromašnih osoba
Authors: Erent-Sunko Zrinka , Kuzelj Valentino , Kvartuč Domeniko
Published: December 2022

Kažnjavanje prosjačenja i skitnje relikt je prijašnjih, nedemokratskih pravnih sustava te je neprihvatljivo sa stajališta suvremene demokratske i socijalne ustavne države. Stoga valja izvući pouke iz povijesnoga engleskog iskustva iz razdoblja tzv. siromaškog prava prije negoli se pristupi razmatranju sankcioniranja prosjaka i skitnica u suvremenome hrvatskom pravnom poretku. Ustavni koncept socijalne države i načelo socijalne pravde postavljaju pozitivni zahtjev zakonodavcu na osiguranje minimuma egzistencije siromašnih osoba potrebnog za ostvarenje ljudskog dostojanstva te negativnu obvezu suzdržavanja od sankcioniranja siromašnih. U tom kontekstu neprihvatljivo je kažnjavanje prosjačenja i skitnje u suvremenome hrvatskom pravnom poretku. Jednako je neprihvatljivo oduzimanje prosjačenjem stečene imovinske koristi. S aspekta ustavne vrednote nepovredivosti vlasništva i ustavnog jamstva prava vlasništva ne bi smjelo biti mjesta oduzimanju stvari / gotova novca stečenih na osnovi darovanja prosjaka. Stoga se u radu postavlja teza o nužnosti napuštanja kažnjavanja prosjačenja i skitnje kao relikta socijalističkog, ali i prijašnjih nedemokratskih razdoblja.
Keefektifan Model Pembelajaran Konstruktivis Berbasis Ugi (Siri ’Na Pesse) untuk Meningkatkan Karakter Siswa
Authors: Subaedah Subaedah , Banna Andi , Abdullah Nuraeni , Multazam Ahmad Muladi
Published: December 2022

Saat ini, Siswa cenderung meniru budaya asing karena mereka hebat dan mereka mempengaruhi hilangnya pengakuan terhadap nilai-nilai budaya lokal mereka. Guru perlu menjadi inovatif dalam menyajikan materi pengajaran dengan cara yang efektif dan memperkenalkan budaya Bugis. Penelitian ini bertujuan untuk Mengembangkan Karakter Siswa dengan menerapkan Model Pembelajaran Konstruktivis Berbasis Ugi (Siri ’Na Pesse) di Sekolah Dasar Negeri Lalabata, Distrik Tanete Rilau, Distrik Barru. Jenis penelitian ini adalah penelitian eksperimental. Penelitian ini melibatkan 25 siswa yang berada dalam satu kelas. Penilaian dievaluasi dan diklasifikasikan oleh guru berdasarkan standar kurikulum Indonesia terbaru. Kemudian, analisis deskriptif digunakan untuk menggambarkan mean dan standar deviasi tanda. Hasil penelitian menunjukkan model pembelajaran konstruktivis berbasis Ugi melalui siri 'na pesse meningkatkan karakter siswa pendidikan dasar secara efektif. Implementasi model pembelajaran konstruktivis berbasis Ugi melalui siri 'na pesse dan post test menunjukkan bahwa 100% siswa meningkatkan karakter. Uji-t berpasangan menunjukkan bahwa ada perbedaan yang signifikan secara statistik antara tanda rata-rata dari pra dan pasca-tes untuk setiap tahap karena semua hipotesis nol ditolak pada tingkat signifikansi 5%. Dengan demikian, analisis statistik berfungsi sebagai bukti bahwa model pembelajaran konstruktivis berbasis Ugi melalui siri 'na pesse efektif dalam meningkatkan karakter siswa.
Pengaruh Komunikasi Interpersonal Guru Terhadap Keaktifan Belajar Peserta Didik pada Mata Pelajaran Pendidikan Agama Islam
Authors: Fajarwati Indah , Syahid Akhmad , Surani Surani , Wahab Abdul
Published: December 2022

This study aims to determine the interpersonal communication of PAI teachers at SMA Negeri 8 Makassar. The learning activity of PAI students at SMA Negeri 8 Makassar, as well as the influence of teacher interpersonal communication on the learning activities of PAI students at SMA Negeri 8 Makassar by using quantitative descriptive types. And the data analysis method is a simple linear regression with SPSS 25 program and the frequency percentage formula. The total population is 864 students, while the sample taken by the author is a random sample of 10% of the population, namely 86 respondents. Interpersonal communication of PAI teachers based on the perceptions of students, the total average of interpersonal communication of PAI teachers is 39.16, which means that the interpersonal communication of PAI teachers is in the high category and the learning activity of PAI students in SMA. Negeri 8 Makassar is a total of 64 questionnaires. ,35 means that based on the perceptions of students, active learning. PAI students are in the high category. The results of the analysis using simple linear analysis in the SPSS program show a simple regression formula which is known that the learning activity of students is influenced by 1,269 points of teacher interpersonal communication plus a constant value of 18,631. The other 3% is influenced by other variables.
Konsep Pendidikan Akhlak Menurut Syekh Al-Zarnuji Dalam Kitab Ta'lim Al-Muta'allim
Authors: Zainal Abdul Qahar , Ansar Ansar
Published: December 2022

This study discusses the concept of moral education according to Sheikh Al-Zarnuji in the book of Ta'lim Al-Muta'allim. This research is focused on analyzing the concept of moral education according to Sheikh Al-Zarnuji in the Book of Ta'lim Al-Muta'allim. Data analysis used the descriptive qualitative method. The researcher's main research instrument is the researcher himself, who identifies, classifies, and analyzes data from any data needed to complete the research. The findings reveal that the book of Ta'lim Al-Muta'allim has 13 significant conversations, including the essence of science, the law of pursuing knowledge, and its significance. Set a goal to learn something new; choose ability, teachers, friends, and learning perseverance; About how to respect science and teachers; about honesty in pursuing understanding, noble and noble character, and values; and how to respect science and teachers. Concerning the beginning of education, its scope, and discipline, Tawakkal and surrender to God are two words that come to mind when I think of Tawakkal. Concerning the study period; Concerning loving and guiding one another; Concerning the study period; Concerning the study period; Concerning the study period; Take knowledge for example; The current state of study; Things that can both increase and weaken memorization; Things that make it easier to bring good fortune, prolong life, and save energy are all good things. Regarding moral education itself, three broad lines form the foundation of moral education: the Value of Moral Education to Allah SWT; The Value of Moral Education Towards Themselves; and moral education towards fellow creatures.
Pembelajaran Berbasis Multimedia Interaktif Mahasiswa Di Perguruan Tinggi
Authors: Karim Bisyri Abdul , Ansar Ansar
Published: December 2022

This study examines the interactive multimedia-based learning of students in higher education. The method used in this research study is library research. The procedure of this research using the stages of library research include; (1) selecting study topics, (2) exploring information, (3) formulating the focus of writing, (4) collecting data sources, (5) preparing data presentations, and (6) compiling reports in the form of research journal descriptions. This research data collection technique relies on documentation sources by exploring sources related to the focus of the problem being studied. The data analysis technique uses content analysis to obtain the substance from appropriate and verifiable references based on the source through the stages of sorting and comparing various definitions and opinions from existing literature sources to achieve the suitability of relevant sources. The results of the analysis of this study can be concluded that; First, learning is an important process that greatly determines behavior change and improvement. In the context of higher education learning, lecturers are required to be more adaptive to various learning tools or media. Learning in higher education will be more interesting by using learning media. Second, learning media plays a very effective role. One type of this media is interactive multimedia whose contents combine various forms of media such as text, audio, and video to make it easier for students to use it in learning. Lecturers must be more innovative in using this interactive multimedia and must be skilled at technological developments.
Telaah Problematika Anak Slow Learner dalam Pembelajaran
Authors: Mansyur Abd. Rahim
Published: December 2022

This study reviews the problems of slow learners in learning. Literary references slow learners to teachers providing learning and parents in providing assistance to children at home during online learning. Based on the results of the study that has been carried out, it is concluded that slow learner children are children who experience learning delays. This can be shown in situations where a child has not been able to master the learning information conveyed by the teacher within a certain time limit. The characteristics of these children are one level above mentally retarded children so they need teacher responses and regular assistance to help them develop themselves. Teachers must observe and identify children who are slow learners to be given counseling assistance that can stimulate cognitive, affective, physical, and intuitive aspects. Counseling should also educate children to use devices in a positive way during online learning.
Analisis Kesulitan Belajar Bahasa Arab Siswa Kelas IX Di SMP IT Insan Cendikia Makassar
Authors: Farid Muhammad , Wahab Abdul , Ansar Ansar
Published: December 2022

This study discusses difficulties in learning Arabic and aims to determine the forms of difficulties in learning Arabic for grade IX students, and efforts to overcome learning difficulties in Arabic subjects at SMPIT Insan Cendekia Makassar. This type of research is qualitative research. The subjects of this study were teachers and students. The determination of the research subjects was carried out using a purposive sampling technique, totaling 10 informants. Methods of data collection using interviews, observation, and documentation. The results showed that there were forms of difficulty in learning Arabic for grade IX students at SMP IT Insan Cendekia Makassar, namely internal and external factors, internal factors consisted of cognitive, affective, and psychomotor. the student, then the external factors consist of the family environment and the school environment, efforts to overcome the difficulties of the Arabic language made by teachers and students by applying the vocabulary method and using textbooks or dictionaries.
Comunicação não violenta como tecnologia leve no contexto da enfermagem: revisão integrativa
Authors: Tobase Lúcia , Cardoso Sandra Helena , Rodrigues Renata Tavares Franco , Bella Eva Cristina Possas Machado , Souza Dhieizom Rodrigo de , Peres Heloisa Helena Ciqueto
Published: December 2022

Objetivo: Verificar como a Comunicação Não Violenta é aplicada na Enfermagem e compreender as repercussões dos profissionais, pacientes e organização. Métodos: Revisão integrativa norteada pela questão “Como a comunicação não violenta é utilizada na área da Enfermagem e quais as repercussões dessa aplicação?”. Realizadas buscas de estudos primários publicados entre 2010 e 2020, nas bases PubMed, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Embase, Psycinfo e Biblioteca Virtual em Saúde. Resultados: Selecionados cinco estudos relacionando comunicação não violenta com trabalhadores da Enfermagem, estratégias de enfrentamento ao assédio moral; gerenciamento de conflitos; enfrentamento da violência familiar e estratégia para ética a estudantes de Enfermagem. Conclusão: A Comunicação Não Violenta foi aplicada na implementação da cultura de paz no ambiente de trabalho, relações profissionais e formação do enfermeiro. O número de estudos incluídos evidencia necessidade de pesquisas sobre a temática.
Etyka naukowych badań społecznych. Pomiędzy kodyfikacją i instytucjonalizacją a praktyką badawczą
Authors: Surmiak Adrianna
Published: December 2022

W ostatniej dekadzie można zaobserwować postępującą w naukach społecznych kodyfikację i instytucjonalizację etyki badań. Powstaje coraz więcej kodeksów etycznych, które standaryzują zasady etycznego prowadzenia badań oraz komisji etycznych kontrolujących projekty badawcze. Za kodyfikacją oraz instytucjonalizacją etyki naukowych badań społecznych stoi między innymi przekonanie, że kodeksy i komisje etyczne znacząco przyczynią się do etycznego postępowania badaczek i ochronią podmioty zaangażowane w badania, szczególnie ich uczestników, przed krzywdą. W artykule argumentuję, że to nie wystarczy, gdyż zarówno osoby prowadzące badania, jak i komisje etyczne powinny kierować się w swoich decyzjach etycznych wyobraźnią moralną.
Interaction between sarcopenia and nonalcoholic fatty liver disease
Authors: Joo Sae Kyung , Kim Won
Published: December 2022

Sarcopenia and nonalcoholic fatty liver disease (NAFLD) are common health problems related to aging. Despite the differences in their diagnostic methods, several cross-sectional and longitudinal studies have revealed the close link between sarcopenia and NAFLD. Sarcopenia and NAFLD are linked by several shared pathogenetic mechanisms, including insulin resistance, hormonal imbalance, systemic inflammation, myostatin and adiponectin dysregulation, nutritional deficiencies, and physical inactivity, thus implicating a bidirectional relationship between sarcopenia and NAFLD. However, there is not sufficient data to support a direct causal relationship between sarcopenia and NAFLD. Moreover, it is currently difficult to conclude whether sarcopenia is a risk factor for nonalcoholic steatohepatitis (NASH) or is a consequence of NASH. Therefore, this review intends to touch on the shared common mechanisms and the bidirectional relationship between sarcopenia and NAFLD.
Analisis Kemampuan Literasi Matematika Siswa Kelas XI	SMA Bahrul Maghfiroh Malang
Authors: Sidik Ahmad , Rochsun Rochsun
Published: December 2022

Mathematical literacy is the individual's ability to formulate, apply, and interpret mathematics in various contexts. This ability includes mathematical reasoning and the ability to use mathematical concepts, procedures, facts and mathematical functions to describe, explain and predict a phenomenon. The purpose of this study was to describe the Analysis of Mathematical Literacy Ability for Class XI Students of SMA Bahrul Maghfiroh Malang. The approach used in this study is a qualitative approach. The subjects studied were 6 students of class XI IPA who were active, passive and moderate. The data collection techniques used were 1) Observation, 2) Written Test, 3) Interview and 4) Documentation. The research instruments used were 1) test question sheets, 2) interview tools and 3) documentation. The validity of the data used was Source Triangulation. Subjects 1 and 2 were passive students so they were unable to complete the test questions correctly. Subjects 3 and 4 were active students so that the subjects were able to complete the test questions perfectly. Subjects 5 and 6 are ordinary students so that the subject can answer the test questions correctly even though the work is not perfect. The conclusion is that students who are active in participating in classroom learning activities have better mathematical literacy skills.
Tindak Tutur Direktif dalam Pidato Presiden Joko Widodo di Masa Pandemi Covid-19
Authors: Mulyaningrum Wieke , Sumarti Endang
Published: December 2022

The directive speech act is a speech act that functions to encourage the speech partner to do something as desired by the speaker. Speech is an activity of speaking in public that conveys information aimed at many people. Speeches are only delivered by certain people such as the president, governors, mayors, and so on. A speech act is a speech that has a directive meaning which functions to influence other people to do something as desired by the speaker. This study aims to obtain an objective picture of the directive speech acts in President Joko Widodo's speech during the Covid-19 pandemic. This research uses a qualitative approach. The research found that directive speech acts include a form of the command with a commanding function, a form of request with a function of asking, an invitation form with an inviting function and a form of advice with an advise function.
Pengembangan Bahan Ajar Biologi Berbasis Flipbook Maker Dipadu dengan Model Problem Based Learning pada Materi Sel untuk Siswa Kelas XI SMA
Authors: Barnett Elisabeth , Arifin As’ad Syamsul
Published: December 2022

The purpose of the development in this research is to develop Flipbook Maker-Based Biology Teaching Materials Combined with Problem Based Learning (PBL) Models in Cell Materials of Class XI High School Students. This type of research is development research. The development model used is a R&D development model consisting of 5 stages Namely data collection (information collection), planning, preliminary field testing (preliminary field testing), product revision (Dwiantoro & Kusumandari, 2016). The results of the research were given by material experts with a percentage of 92.85% with a very valid category, while research from a media expert lecturer with a percentage of 83.69% with a fairly valid category and an assessment of 10 students with a percentage of 93.33% and declared very valid. Based on the results of the assessment obtained, it can be concluded that the flipbook maker-based biology teaching materials are combined with the problem-based learning (PBL) model so that it can increase students' interest in learning this can be seen from the approach used including quantitative and qualitative approaches with data analysis techniques in the form of questionnaires. The response from the representatives of 10 students and the results obtained was a percentage of 93.33%, then the teaching material was declared "very valid" so that it could be tested.
Pengembangan Media Pembelajaran Interaktif Berbasis Moodle pada Mata Pelajaran Bahasa Inggris
Authors: Zuroida Hilma , Fitriani Enis , Astuti Endang Setiyo
Published: December 2022

The present research aims to create an interactive learning media based on Moodle in English subjects at SMK Muhammadiyah 7 Gondanglegi. There are a number of reasons why this research was conducted. The results of observations and analysis of the initial needs show that there is no learning media that can connect students and teachers when students have on the job training class outside for approximately 3 months. So such an interactive media is needed that can bridge those needs. This research was conducted by adopting the Robert Maribe Branch Development Research design with the ADDIE model. This model is implemented into the following procedures, namely, (1) analysis, (2) design, (3) development, (4) implementation, and (5) evaluation. In this study, researchers reached the development stage and the final product without carrying out trials or implementations due to the limited time of research. The results of this study is an interactive web-based media based on Moodle. The results of the media expert validation of the teachers of SMK Muhammdiyah 7 Gondanglegi reached 87% with very good category. The results of the material expert validation from lecturers of IKIP Budi Utomo Malang achieved 95% with the very good category too. Finally, it can be concluded that web-based teaching media with Moodle are suitable media for the needs of English classes at SMK Muhamadiyah 7 Gondanglegi.
Pengembangan Bahan Ajar dengan Penguatan Karakter pada Materi Bangun Ruang untuk Sekolah Dasar
Authors: Rachma Rachmawati , Wijayanti Rina , Anugraini Asri Putri
Published: December 2022

The purpose of this study to produce learning materials based character building. Character building refers to the PPK where there are five main character that come from Pancasila, namely religion, nationalism, integrity, independence and mutual cooperation. At the elementary education level, the portion of character building provided is greater than knowledge. This underlies researchers to develop learning materials based on character building. Learning materials contain material with strengthening character building, and student activity columns that aim to explore knowledge by inserting strengthening character education and question exercises

This is a development research. The development procedure refers to the ADDIE development model (Analyze, Design, Develop, Implementation and Evaluation). The research begins with Analyze, which is needs analysis through observation and interviews, then design is designing teaching materials. The next stage is develope, which is developing with validation to experts, then followed by the implementation stage, namely by implementing trials of teaching materials to students with the teacher. The last step is evaluation, namely conducting an evaluation after the implementation of teaching materials. Instruments in the form of expert validation sheets (material and media experts), test questions and student interview sheets. The results of the validation of the teaching materials developed show that the category is feasible in terms of validity, practicality, and effectiveness.
SubSurface Flow-Wetlands dengan Tanaman Air untuk Menurunkan Kadar COD pada Limbah Cair Tahu
Authors: Munawwaroh Anita , Lestari Endang Sri
Published: December 2022

Karakteristik limbah cair industri tahu umumnya mengandung zat organik tinggi. Kandungan zat organik dapat menyebabkan pertumbuhan mikroba dalam air secara cepat. Sehingga akan mengakibatkan kadar oksigen dalam air menurun tajam dan kadar COD tinggi. Untuk itu diperlukan sistem pengolahan air limbah yang murah dan efisien agar dapat mengatasi permasalahan tersebut dengan menggunakan SubSurface Flow-Wetlands. Penelitian ini bertujuan untuk mengetahui pengaruh SSF-Wetlands dengan tanaman Eichhornia crassipes dan Pistia stratiotes L. dalam menurunkan kadar COD pada limbah cair tahu. Prosedur penelitian ini antara lain (1) Tahap Pengambilan sampel yaitu sampel limbah cair tahu dan sampel tanaman eceng gondok dan kayu apu. 2) Tahap Pembuatan SSF-Wetlands, (3) Tahap pengolahan limbah dengan SSF-Wetlands dan tanaman air. (4) Tahap pengujian COD. Kemudian data dianalisis menggunakan ANOVA satu arah. Hasil penelitian ini diperoleh kadar COD awal pada limbah cair tahu  sebesar 12.500 mg/L. Namun, limbah cair tahu yang diolah menggunakan SSF-Wetlands dengan tanaman air mampu menurunkan kadar COD sampai 10.000 mg/L. Penurunan kadar COD tersebut disebabkan bahan padatan mulai mengendap sehingga bahan buangan di air limbah juga berkurang. Selain itu, sebagian bahan buangan telah teroksidasi dan sebagian lagi juga telah terserap oleh tanaman sehingga mengurangi kadar COD. Berdasarkan hasil uji Duncan menunjukkan bahwa tidak ada perbedaan yang nyata pada perlakuan A1, A2 dan A3. Namun, perlakuan tersebut berbeda nyata dengan perlakuan A4. Dimana perlakuan SSF-Wetland dengan eceng gondok dan kayu apu (A4) menghasilkan kadar COD yang lebih tinggi dibandingkan dengan perlakuan yang lainnya yaitu sebesar 2420 mg/L.
Intra-Abdominal Candidiasis
Authors: Azim Afzal , Ahmed Armin , Baronia Arvind Kumar , Marak Rungmei S. K. , Muzzafar Nabeel
Published: December 2022

Intra-abdominal candidiasis (IAC) is the second most common form of invasive candidiasis after candidaemia. IAC is a broad term and can be classified on the basis of anatomical site (Candida peritonitis, pancreatic candidiasis, biliary tract candidiasis, gastrointestinal candidiasis, and hepatosplenic candidiasis) as well as clinical setting (community acquired versus nosocomial). The risk factors linked with IAC are candida colonisation, anastomotic leak, multiple instrumentation, long-term broad spectrum antibiotic use, total parenteral nutrition, and immunocompromised state. Clinically, IAC is not different from intraabdominal bacterial infection. Patients generally present with signs and symptoms of intra-abdominal sepsis after not responding to antibiotic therapy and with a background history of multiple surgical interventions or history of delayed source control. Radiological investigations, like ultrasonography and computed tomography scan, not only aid in diagnosis but also assist in differentiating medical from surgical cases. Microbiological diagnosis requires isolation of candida from an intra-abdominal specimen. Differentiation between colonisation and infection is difficult. Generally, progressive and persistent colonisation is associated with high risk of infection. Blood cultures have poor sensitivity for IAC. Non-culture based techniques used for diagnosis are mannan/anti-mannan assay, beta-D glucan assay, and validated polymerase chain reaction. Four types of antifungal strategies described in the literature are prophylaxis (risk factor driven), pre-emptive (colonisation or biomarker driven), empirical (fever driven), and targeted therapy (microbiology driven). Over recent years, global epidemiology has shown a shift from Candida albicans to non-albicans. Local epidemiology plays an important role in selection of the appropriate empirical therapy. The purpose of this review is to discuss different types of IAC based on their classification, risk factors, and management.
Türk Dış Politikasında Batı Balkanlar: Uzman Mülakatlarına Dayalı Swot Analizi
Authors: CANVEREN Önder
Published: December 2022

Bu makale, Adalet ve Kalkınma Partisi (AKP) iktidarlarının Batı Balkanlara yönelik dış politikasını irdelemektedir. Uzman mülakatı ile toplanan veriler, Türkiye’nin güçlü ve zayıf yönleri ile bölgede sahip olduğu fırsatları ve karşılaştığı tehditleri sıralamak için kullanılmıştır. ‘Türk dış politikası ve Batı Balkanlar’ konusunda uzman 15 akademisyen/araştırmacı ile gerçekleştirilen yapılandırılmış mülakatlar için – Güçlü yönler (Strength), Zayıf yönler (Weakness), Fırsatlar (Opportunities) ve Tehditler (Threat) kelimelerinin baş harflerinden oluşan SWOT analizi yapılmıştır. Türkiye’nin bölge ile olan tarihsel-sosyolojik bağları, yumuşak güç ve kamu diplomasisi, ekonomik ve ticari gündemi de dâhil dış politika aktivizmi ‘güçlü’ yönleri; bölgedeki olumsuz algısı, siyasi ve ekonomik istikrarsızlığı, uluslararası rekabet ve Batı ile yaşanan sorunlar ve son olarak bürokratik problemler, ‘zayıf’ yönleri olarak karşımıza çıkmaktadır. İktisadi-ticari potansiyel ve kimlik temelli fırsatlar, alternatif güçlerin kapasite ve etkinlikleri ile Türkiye’nin Euro-Atlantik ağı, bölgede sahip olduğu ‘fırsatlar’; alternatif güçler ve artan rekabet, iktidarın mevcut dış politikasından kaynaklanan sorunlar ve bölgenin kendi dinamiklerinin yarattığı belirsizlikler, bölgede karşılaştığı ‘tehditler’ olarak sıralanmaktadır. Türkiye’nin bölgede sürdürülebilir bir dış politika izleyebilmesi için kurumsallaşma kapasitesini ve inisiyatiflerini güçlendirmesi, daha da önemlisi bölgeye ilişkin kapsayıcı yeni bir yaklaşım benimsemesiönerilmektedir.
A ESCOLA É UM ESPAÇO DEMOCRÁTICO? DIÁLOGOS EMERGENTES NA FORMAÇÃO CONTINUADA DE PROFESSORAS QUE ENSINAM MATEMÁTICA NOS ANOS INICIAIS DO ENSINO FUNDAMENTAL
Authors: dos Santos Cezar Mariana , Rocha de Oliveira Samuel
Published: December 2022

O artigo tem por objetivo fomentar reflexões e apresentar diálogos a respeito da democracia no contexto escolar, mais especificamente acerca de como vivenciamos e percebemos a democracia ou a ausência dela no âmbito educacional. Assim, discutir democracia, nesta pesquisa, se tornou emergente na medida em que (re)conhecemos a importância de vivenciar e perceber a democracia nos espaços escolares nos quais estamos inseridos. Esta investigação de abordagem qualitativa, com característica de pesquisa-ação, apresenta um recorte de uma pesquisa a nível de doutorado, que foi realizada com cinco professoras dos anos iniciais do Ensino Fundamental de uma escola estadual de São Paulo, a partir de uma formação continuada desenvolvida em 2019 na qual o tema Diálogos a respeito da democracia emergiu. Os dados produzidos foram interpretados com base na Análise Dialógica do Discurso, oriunda dos estudos bakhtinianos. Os resultados mostraram que, para se desenvolver atitudes democráticas, a educação precisa alicerçar-se na participação, no respeito às diferenças e na valorização dos saberes de experiência.
O CONTRATO DIDÁTICO NA UTILIZAÇÃO DE OBJETOS DIGITAIS DE APRENDIZAGEM: UMA FORMAÇÃO CONTINUADA PARA PROFESSORAS DA EDUCAÇÃO INFANTIL NUM AMBIENTE VIRTUAL
Authors: Gonçalves Gomes Marques Roberta , de Avelar Brito Lima Anna Paula
Published: December 2022

Apresentamos neste artigo uma discussão acerca do Contrato Didático, analisando as relações contratuais estabelecidas em um ambiente virtual de formação continuada de professoras da Educação Infantil (EI), voltada para o uso de Objetos Digitais de Aprendizagem (ODA). Trata-se de um recorte de uma pesquisa de Doutorado desenvolvida no campo da Didática da Matemática. Para tanto, abordamos essa problemática por meio da noção de Contrato Didático, proposta por Brousseau (1986), investigando-o em um contexto de ensino diferente dos comumente explorados quando da pesquisa sobre esse fenômeno didático. Participaram do estudo onze professoras da EI. O referente artigo elege a noção de milieu como aquela que prioritariamente será tratada, no âmbito do Contrato Didático. Elege, igualmente, o saber tecnológico – ODA – como o que será prioritariamente enfocado, em detrimento do saber matemático em si, dado o objetivo dessa pesquisa. Todavia, os autores não se furtarão de abordar questões relativas ao saber matemático. Foram realizadas entrevistas semiestruturadas, de modo virtual, além de um curso de formação continuada virtual sobre a utilização de Objetos Digitais de Aprendizagem, desenvolvidos pelo repositório OBAMA. Os resultados apontaram que a relação contratual estabelecida entre os atores envolvidos apresentou particularidades próprias de uma relação didática pouco vivenciada pelas professoras: o contexto virtual e o domínio de ODA, sobretudo para utilização na EI. O estudo também revelou que há elementos contratuais observados em contextos ordinários, que caracterizam o núcleo duro do contrato, que também foram identificados no ambiente virtual, inclusive com a interferência da realização ou não, por parte dos envolvidos, de acordos previstos também no Contrato Pedagógico.
AS TECNOLOGIAS DIGITAIS DA INFORMAÇÃO E COMUNICAÇÃO NA FORMAÇÃO INICIAL DE PROFESSORES DE MATEMÁTICA: PERCEPÇÕES DE FORMANDOS DA UNIVERSIDADE FEDERAL DO PARÁ
Authors: Augusto das Chagas Barros Marlon , Vilhena da Silva Paulo , Ruiz Gomes Cristiane
Published: December 2022

As tecnologias digitais da informação e comunicação estão cada vez mais presentes em nosso cotidiano, sendo ferramentas indispensáveis para nossa sobrevivência e apresentando avanços que promovem a possibilidade de mudança em diversos setores da sociedade, incluindo a educação. Entretanto, um dos principais desafios para a integração desses recursos nos ambientes de ensino e aprendizagem é a falta de formação docente adequada, justificando a necessidade de trabalhos que visem explorar aspectos acerca da formação docente quanto a utilização dos meios digitais. Portanto, neste trabalho, buscamos analisar se, na opinião de discentes concluintes, o curso de Licenciatura em matemática do campus de Belém da Universidade Federal do Pará (UFPA) os capacitou para a utilização das tecnologias digitais da informação e comunicação em sua atuação profissional. Para tal, o projeto pedagógico do curso foi analisado a fim de observar, na formação inicial, os aspectos relacionados aos meios digitais e embasar a construção de um questionário eletrônico para analisar a opinião dos formandos acerca de sua formação inicial quanto a utilização dos meios digitais. Os resultados apontam que, na UFPA, o projeto pedagógico do curso de licenciatura em matemática, campus Belém, apresenta poucos incentivos no que se refere a utilização de recursos digitais nas práticas profissionais. Além disso, a maioria dos discentes concluintes relatou, no questionário aplicado, descontentamento com sua formação inicial na parte de manejo das tecnologias digitais, deixando reflexões sobre a eficiência da formação inicial na perspectiva de uso desses recursos.
Baseline robot-measured kinematic metrics predict discharge rehabilitation outcomes in individuals with subacute stroke
Authors: Goffredo Michela , Proietti Stefania , Pournajaf Sanaz , Galafate Daniele , Cioeta Matteo , Le Pera Domenica , Posteraro Federico , Franceschini Marco
Published: December 2022

Background:The literature on upper limb robot-assisted therapy showed that robot-measured metrics can simultaneously predict registered clinical outcomes. However, only a limited number of studies correlated pre-treatment kinematics with discharge motor recovery. Given the importance of predicting rehabilitation outcomes for optimizing physical therapy, a predictive model for motor recovery that incorporates multidirectional indicators of a patient’s upper limb abilities is needed.

Objective:The aim of this study was to develop a predictive model for rehabilitation outcome at discharge (i.e., muscle strength assessed by the Motricity Index of the affected upper limb) based on multidirectional 2D robot-measured kinematics.

Methods:Re-analysis of data from 66 subjects with subacute stroke who underwent upper limb robot-assisted therapy with an end-effector robot was performed. Two least squares error multiple linear regression models for outcome prediction were developed and differ in terms of validation procedure: the Split Sample Validation (SSV) model and the Leave-One-Out Cross-Validation (LOOCV) model. In both models, the outputs were the discharge Motricity Index of the affected upper limb and its sub-items assessing elbow flexion and shoulder abduction, while the inputs were the admission robot-measured metrics.

Results:The extracted robot-measured features explained the 54% and 71% of the variance in clinical scores at discharge in the SSV and LOOCV validation procedures respectively. Normalized errors ranged from 22% to 35% in the SSV models and from 20% to 24% in the LOOCV models. In all models, the movement path error of the trajectories characterized by elbow flexion and shoulder extension was the significant predictor, and all correlations were significant.

Conclusion:This study highlights that motor patterns assessed with multidirectional 2D robot-measured metrics are able to predict clinical evalutation of upper limb muscle strength and may be useful for clinicians to assess, manage, and program a more specific and appropriate rehabilitation in subacute stroke patients.
Endplate volumetric bone mineral density biomechanically matched interbody cage
Authors: Weng Yuanzhi , Di Mingyuan , Wu Tianchi , Ma Xinlong , Yang Qiang , Lu Weijia William
Published: December 2022

Disc degenerative problems affect the aging population, globally, and interbody fusion is a crucial surgical treatment. The interbody cage is the critical implant in interbody fusion surgery; however, its subsidence risk becomes a remarkable clinical complication. Cage subsidence is caused due to a mismatch of material properties between the bone and implant, specifically, the higher elastic modulus of the cage relative to that of the spinal segments, inducing subsidence. Our recent observation has demonstrated that endplate volumetric bone mineral density (EP-vBMD) measured through the greatest cortex-occupied 1.25-mm height region of interest, using automatic phantomless quantitative computed tomography scanning, could be an independent cage subsidence predictor and a tool for cage selection instruction. Porous design on the metallic cage is a trend in interbody fusion devices as it provides a solution to the subsidence problem. Moreover, the superior osseointegration effect of the metallic cage, like the titanium alloy cage, is retained. Patient-specific customization of porous metallic cages based on the greatest subsidence-related EP-vBMD may be a good modification for the cage design as it can achieve biomechanical matching with the contacting bone tissue. We proposed a novel perspective on porous metallic cages by customizing the elastic modulus of porous metallic cages by modifying its porosity according to endplate elastic modulus calculated from EP-vBMD. A three-grade porosity customization strategy was introduced, and direct porosity-modulus customization was also available depending on the patient’s or doctor’s discretion.
Substitution of manure for mineral P fertilizers increases P availability by enhancing microbial potential for organic P mineralization in greenhouse soil
Authors: Sun Ruibo , Niu Junfang , Luo Bingbing , Wang Xiaogai , Li Wenyan , Zhang Wenjie , Wang Fenghua , Zhang Chaochun , Ye Xinxin
Published: December 2022

The shortage of phosphorus (P) as a resource represents a major challenge for the sustainable development of agriculture. Manure has a high P content and is a potential substitute for mineral P fertilizers. However, little is known about the effects on soil P availability and soil microbial P transformation of substituting manure for mineral P fertilizers. In this study, variations in soil P availability and bacterial P mobilization were evaluated under treatment with manure as compared to mineral P fertilizers. In the greenhouse fruit and vegetable production system that provided the setting for the study, substitution of manure for mineral P (PoR treatment) resulted in a similar level of soil total P and a similar fruit and vegetable yield as compared to traditional fertilization, but a significantly increased level of soil available P. In addition, PoR treatment enhanced bacterial organic P mineralization potential and decreased inorganic P dissolution potential. These results demonstrate that manure application increases the availability of soil P primarily by enhancing soil microbial Po mineralization, indicating the potential feasibility of applying manure instead of mineral P fertilizers in greenhouse farming.
Modulation of sirtuins during monolayer chondrocyte culture influences cartilage regeneration upon transfer to a 3D culture environment
Authors: Heywood Hannah K. , Thorpe Stephen D. , Jeropoulos Renos M. , Caton Paul W. , Lee David A.
Published: December 2022

This study examined the role of sirtuins in the regenerative potential of articular chondrocytes. Sirtuins (SIRT1-7) play a key role in regulating cartilage homeostasis. By inhibiting pro-inflammatory pathways responsible for cartilage degradation and promoting the expression of key matrix components, sirtuins have the potential to drive a favourable balance between anabolic and catabolic processes critical to regenerative medicine. When subjected to osmolarity and glucose concentrations representative of the in vivo niche, freshly isolated bovine chondrocytes exhibited increases in SIRT1 but not SIRT3 gene expression. Replicating methods adopted for the in vitro monolayer expansion of chondrocytes for cartilage regenerative therapies, we found that SIRT1 gene expression declined during expansion. Manipulation of sirtuin activity during in vitro expansion by supplementation with the SIRT1-specific activator SRT1720, nicotinamide mononucleotide, or the pan-sirtuin inhibitor nicotinamide, significantly influenced cartilage regeneration in subsequent 3D culture. Tissue mass, cellularity and extracellular matrix content were reduced in response to sirtuin inhibition during expansion, whilst sirtuin activation enhanced these measures of cartilage tissue regeneration. Modulation of sirtuin activity during monolayer expansion influenced H3K27me3, a heterochromatin mark with an important role in development and differentiation. Unexpectedly, treatment of primary chondrocytes with sirtuin activators in 3D culture reduced their matrix synthesis. Thus, modulating sirtuin activity during the in vitro monolayer expansion phase may represent a distinct opportunity to enhance the outcome of cartilage regenerative medicine techniques.
An analysis of the harassments and challenges faced by the public transport users in a developing country of South Asia
Authors: Yasir Samnun , Ahmad Tanzim , Enam Annesha
Published: December 2022

Bangladesh—located in south Asia and home to almost 167 M people, is one of the most densely populated countries in the world. Despite high population density, the country is yet to have a well-coordinated mass transit system. However, most people rely on public transportation due to comparatively low motorization. Public transport users, especially vulnerable cohorts (e.g., women), face enormous challenges, including molestations, assaults, and rape during their daily commute. Few studies that analyzed the state of harassment exclusively focused on women, which might not be comprehensive enough to understand the state of the problem and devise effective policies. Therefore, the current study explores the state of harassment in the three cities of Bangladesh, namely, Dhaka—the capital; Rajshahi; and Mymensingh across all genders. The study also investigates people’s perception of women’s mobility, the experience of using public transport, and the desirable safety precautions to understand the gender differences and the variability across the three cities. A detailed questionnaire survey was conducted to collect data from the three cities. The study found considerable gender differences regarding the perception of women’s mobility hindrances, the experience of using public transportation, and desirable safety precautions. The differences across the three cities were also noticeable. Contrary to the general belief, the study found that people from smaller towns like Mymensingh were more likely to get harassed than those from the bigger cities like Dhaka and Rajshahi—insinuating the lack of reporting from the smaller towns of the country. The findings from the study could be helpful for the transit and city planners in creating a conducive transit ambiance in Bangladesh. Based on the desirable safety precautions, female-only rides, especially at night, would be beneficial. City planners could also plan small and medium business activities around transit stops to attract the crowd and reduce the possibility of getting harassed while walking alone to access transit.
Advancing the use of the repertory grid technique in the built environment: A systematic review
Authors: Rahman Rawan , Bidoun Dana , Agiel Ahmed , Albdour Ala'
Published: December 2022

Since the development of personal construct theory, the repertory grid technique (RGT) has been the most recognized tool to elicit personal constructs. Although RGT was found to be a viable scientific and practical method in different fields, its utilization in the built environment has been extremely limited. Therefore, this study aimed to explore RGT as a research method and advance its use in the built environment field. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, this study conducted a systematic review to identify studies on Scopus that have used RGT before 2021. These studies were investigated according to subject area, location, year of publication, aim, and research design. Among the 782 studies contributing to more than 24 subject areas, 30 used RGT within the built environment scope. Results indicated the validity of RGT to the built environment by exploring different ways it may be employed. This review strongly recommends advancing the use of RGT in the built environment and taking advantage of its potential.
Toward sustainability in zeolite manufacturing: An industry perspective
Authors: Parvulescu Andrei-Nicolae , Maurer Stefan
Published: December 2022

Conventional zeolite manufacturing processes are highly energy-intensive and come along with a significant carbon dioxide footprint. Here, we discuss the main energy consumers and potential alternatives toward a more sustainable production of zeolites: from simple optimization efforts on existing unit operations to new and novel manufacturing concepts such as the continuous crystallization and solidothermal route toward zeolites and their industrial applicability. These efforts contribute to the global effort into transitioning manufacturing of chemicals and catalysts to a net-zero environment by cutting greenhouse gas emissions to as close to zero as possible.
Therapeutic potential of compounds targeting SARS-CoV-2 helicase
Authors: Halma Matthew T. J. , Wever Mark J. A. , Abeln Sanne , Roche Didier , Wuite Gijs J. L.
Published: December 2022

The economical and societal impact of COVID-19 has made the development of vaccines and drugs to combat SARS-CoV-2 infection a priority. While the SARS-CoV-2 spike protein has been widely explored as a drug target, the SARS-CoV-2 helicase (nsp13) does not have any approved medication. The helicase shares 99.8% similarity with its SARS-CoV-1 homolog and was shown to be essential for viral replication. This review summarizes and builds on existing research on inhibitors of SARS-CoV-1 and SARS-CoV-2 helicases. Our analysis on the toxicity and specificity of these compounds, set the road going forward for the repurposing of existing drugs and the development of new SARS-CoV-2 helicase inhibitors.