bluuebunny/crossref_metadata_2025 huggingface dataset:
MOBİL BULUD TEXNOLOGİYALARI: MÖVCUD VƏZİYYƏTİ, PROBLEMLƏRİ VƏ TƏHLÜKƏSİZLİK MƏSƏLƏLƏRİ
Authors:   AMEA İnformasiya Texnologiyaları İnstitutu, Ələkbərov Rəşid
Published: February 2021

Məqalədə mobil qurğularda böyük hesablama və yaddaş resursları tələb edən məsələlərin həllində meydana çıxan problemlər (resurs qıtlığı və enerji sərfiyyatı) analiz edilmişdir Bu problemləri aradan qaldırmaq üçün mobil hesablama buludları (MHB) texnologiyalarından geniş istifadə olunması qeyd edilmişdir. Mobil buludların müxtəlif arxitektur-texnoloji prinsipləri analiz edilmiş və onların üstünlükləri göstərilmişdir. Hesablama buludlarının (HB)-nin modelləri, xidmətləri, xüsusiyyətləri və üstünlükləri göstərilmişdir. MHB-nin mövcud vəziyyəti, imkanları, meydana çıxan problemlər və onların həlli üçün təklif və tövsiyələr verilmişdir. Eyni zamanda, MHB-də təhlükəsizlik və məxfilik məsələləri analiz edilmişdir. Mobil istifadəçilərə böyük hesablama resursları tələb edən məsələlərin həllinə imkanlar yaradan cloudletəsaslı MHB-dən istifadə edilməsi təklif edilmişdir. Eyni zamanda cloudletəsaslı iyerarxik strukturlu MHB-nin arxitektur-texnoloji prinsipləri işlənmiş və onun üstünlükləri göstərilmişdir. Təklif edilən modelin mobil qurğuların hesablama və yaddaş resurslarına olan tələbatını təmin etməsi, şəbəkədə əlaqə kanallarının ötürücülük qabiliyyətinin artırılması, gecikmələrin aradan qaldırılması və təhlükəsizliyin təmin edilməsi qeyd edilmişdir.
MİLLİ E-İMZA İNFRASTRUKTURUNUN AKTUAL ELMİ-TƏDQİQAT PROBLEMLƏRİ
Authors:   AMEA İnformasiya Texnologiyaları İnstitutu, İmamverdiyev Yadigar , Abbasov Həbib ,   NRYTN Milli Sertifikat Xidmətləri Mərkəzi
Published: February 2021

Təqdim olunan araşdırma işində elektron imza (e-imza) ilə bağlı milli e-imza infrastrukturunun mövcud texniki və məntiqi imkanlarını araşdırmaqla, sistemə düşən yükün optimal idarə edilməsi və problemlərin araşdırılıması müəyyən edilib. E-imza vətəndaşların elektron mühitdə identikləşdirilməsi üçün şəxsiyyət vəsiqəsi rolunu təmin etdiyi üçün e-dövlət ekosistemində formalaşdırılan informativ və interaktiv elektron xidmətlərə əlçatanlığın təmin edilməsi və bu xidmətlərdən təhlükəsiz istifadə edilməsi e-imza vasitəsi ilə həyata keçirilir. Məqalədə milli e-imza infrastrukturunun yeni texnoloji çağırışlar, mobillik imkanlarının artırılması, məhdud resusrlu qurğularda yüksək məhsuldarlığın təmin edilməsi, e-xidmətlərdən geniş istifadə üçün yüksək təhlükəsizlik tələbləri baxımından təkmilləşdirilməsi problemləri analiz edilir və aktual elmi-praktiki məsələlər müəyyən edilir. Müəyyən edilən problemlərin həlli istiqamətində beynəlxalq təcrübə araşdırılmaqla milli infrastrukturun komponentlərinin təhlükəsizliyinin və inam zəncirnin qiymətləndirilməsi istiqamətində mərkəzlərinin işinin modelləşdirilməsi üçün elmi-tədqiqat istiqamətləri analiz edilmişdir. Məqalədə milli e-imza infrastrukturunun özünün təhlükəsizlik problemlərinin müəyyən edilməsi ilə mərkəzlərin xidmət sahələrində təhlükəszilik komponenti kimi səmərəsi müəyyən edilir.
Penggunaan Gamitifikasi pada Massive Open Online Course (MOOC)
Authors: Nugroho Wirawan Arief , Rini Dyah Puspito
Published: February 2021

Pada era Revolusi Industri 4.0 Gamifikasi dan Massive Open Online Course (MOOC) merupakan fenomena baru dalam pembelajaran terbuka dan dikenal sebagai strategi yang baik untuk meningkatkan kualitas pendidikan. Namun demikian, MOOC memiliki dua kelemahan utama: pertama, kurangnya pemahaman untuk mengetahui sasaran pribadi; dan kedua, tingkat penyelesaian yang rendah dibandingkan dengan jumlah pendaftaran ke MOOCs. Untuk dapat mengatasi dua kelemahan tersebut peneliti mengusulkan pemanfaatan Gamifikasi. Dalam tulisan ini akan diuraikan berbagai penelitian yang berkaitan dengan Gamifikasi dan MOOC. Metodologi penelitian ini menggunakan pendekatan studi literatur. Hasilnya diketahui bahwa MOOC tidak memerlukan tingkat penyelesaian penuh seperti kursus tradisional yang biasanya dianggap sebagai keberhasilan. Selain itu gamifikasi dapat meningkatkan efektifitas MOOC untuk dapat mengatasi masalah utama dalam penerapannya melalui pengguanaan elemen-elemen penting dalam gamifikasi.

Abstract

Since the beginning of the Industrial Revolution 4.0 Gamification and the Massive Open Online Course (MOOC) is a new phenomenon in open learning and is known as a good strategy to improve the quality of education. However, the MOOC has two main disadvantages: first, lack of understanding to know personal goals; and second, the completion rate is low compared to the number of registrations to MOOCs. To be able to overcome these two weaknesses, researchers will propose the use of Gamification. In this paper various studies relating to Gamification and MOOC will be described. The methodology of this research uses a qualitative approach with emphasis on data analysis. The result is that the MOOC does not require a full level of completion like a traditional course which is usually considered a success. In addition, gamification can increase the effectiveness of the MOOC to be able to overcome the main problems in its application through the use of important elements in gamification
Perancangan Knowledge Management System Berbasis Web pada Tenaga Kependidikan Fakultas Teknik Universitas PGRI Madiun
Authors: Anardani Sri , Riyanto Slamet , Setiawan Dimas
Published: February 2021

Tenaga kependidikan merupakan barisan terdepan pelayanan administrasi yang dituntut mampu beradaptasi dengan cepat terhadap perubahan di lingkungan kerja. Secara rutin Universitas PGRI Madiun melaksanakan kegiatan mutasi, rotasi dan pensiun terhadap tenaga kependidikan. Hal ini berdampak pada banyaknya pengetahuan yang hilang karena dibawa oleh tenaga kependidikan yang dipindah atau sudah pensiun. Penelitian ini bertujuan menganalisa perancangan Knowledge Management System berbasis web untuk mengolah data pengetahuan tenaga kependidikan di Fakultas Teknik Universitas PGRI Madiun. Metodologi yang digunakan pada penelitian ini merujuk pada kerangka kerja 10-Step Knowledge Management  Roadmap milik Amrit Tiwana.  Metode perancangan sistem menggunakan pendekatan berorientasi objek dengan tools UML (Unified Modelling Languange). Untuk pengujian kebutuhan fungsioanl sistem menggunakan metode FGD dengan responden tenaga kependidikan fakultas teknik.  Penelitian ini menghasilkan dokumen  rancangan aplikasi KMS yang dapat memberikan rekomendasi bagi lembaga untuk membangun aplikasi KMS di masa depan.

 

Abstract

Educational staff are at the forefront of the administration which is demanded to be able to quickly change in the work environment. The PGRI Madiun University routinely carries out mutation, rotation and retirement activities for educational staff. This has an impact on the amount of knowledge lost because it is carried by the transferred or retired teaching staff. This study aims to analyze the design of a web-based Knowledge Management System to process the knowledge of educational staff in the Faculty of Engineering, University of PGRI Madiun. The methodology used in this study refers to Amrit Tiwana's 10-Step Knowledge Management Roadmap. The system design method uses object-oriented approach with UML (Unified Modeling Language) tools.  To test the system functional requirements requirements using FGD method with engineering faculty respondent. This research produces a KMS application design document that can provide recommendations for institutions to build KMS applications in the future.
Analisis Kualitas Layanan Penyedia Data di Indonesia Menggunakan Metode Servqual
Authors: Sularto Lana
Published: February 2021

Tujuan utama penelitian ini untuk melakukan evaluasi kualitas layanan penyedia data serta mengukur tingkat kepuasan masyarakat pengguna data di Indonesia dengan menggunakan model SERVQUAL. Kualitas layanan diukur dari perspektif masyarakat pengguna data di wilayah Sumatera Utara, Jawa Timur, Sulawesi Selatan, Kalimantan Selatan, NTB, Maluku dan Papua Barat, sehingga dapat lebih mewakili kebutuhan para pengguna data di wilayah Indonesia. Kuisioner terdiri dari kuisioner persepsi dan harapan dengan menggunakan 5 dimensi SERVQUAL : Reliability, Tangibles,  Responsiveness, Empathy dan Assurance. Hasil dari penelitian adalah bahwa kelima dimensi menunjukkan adanya nilai kesenjangan yang negatif, dengan nilai kesenjangan (gap) tertinggi pada dimensi Empathy. Hal tersebut menunjukkan ketidakpuasan pengguna data terhadap layanan penyedia data. Dapat diambil kesimpulan bahwa kualitas layanan penyedia data di Indonesia, belum memenuhi kebutuhan dan keinginan para pengguna data, sehingga perlu dilakukan upaya perbaikan terhadap setiap dimensi yang telah diukur agar dapat meningkatkan kualitas atas layanan.

 

Abstract

The main purpose of this research is to conduct a quality of service of data provider institutions for various business and research purposes as well as measuring the level of satisfaction of the user community in Indonesia using the SERVQUAL model. Measurement of service quality from the point of view of data user communities in the regions of North Sumatra, East Java, South Sulawesi, South Kalimantan, NTB, Maluku and West Papua, to represent user needs of data in Indonesia. The questionnaire consisted of a perception and expectation questionnaire using 5 SERVQUAL dimensions namely Reliability, Tangibles,  Responsiveness, Empathy and Assurance. Results showed a negative gap value for all 5 dimensions, where the dimension of empathy has the highest gap. These findings indicate dissatisfaction with data provider services, the conclusion is the quality of data provider services in Indonesia, does not meet the users needs and desires, so it is necessary to make improvements to each dimension that has been measured (eliability, Tangibles,  Responsiveness, Empathy and Assurance) in order to improve the quality of data provider services.
Sistem Pendukung Keputusan Pendistribusian Air Bersih Menggunakan Mobil Tangki pada PDAM Kota Makassar dengan Menggunakan Metode TOPSIS
Authors: Asrul Billy Eden William , Zuhriyah Sitti
Published: February 2021

PDAM Kota Makassar merupakan perusahaan daerah yang bertugas dalam  pengelolaan dan pemenuhan kebutuhan air bersih bagi masyarakat di kota Makassar. Penyaluran air bersih yang dilakukan PDAM Kota Makassar masih belum mencakup keseluruhan wilayah Kota Makassar,  ini disebabkan karena beberapa hal salah satu diantaranya debit air yang berkurang. Untuk mengatasi hal tersebut pemerintah kota Makassar melalui PDAM, melakukan pendistribusian air dengan cara pengantaran langsung ke rumah warga menggunakan mobil tangki. Proses penyaluran air PDAM mengalami kesulitan untuk menentukan daerah atau warga mana saja yang mendapatkan prioritas pengantaran air bersih, karena armada yang digunakan masih kurang. Mengatasi hal tersebut maka dibuat sebuah Sistem Pendukung Keputusan Pendistribusian Air Bersih, untuk memudahkan prioritas pengantaran air bersih. Metode penelitian melalui empat tahapan yaitu, pengenalan masalah, pengumpulan data, perancangan sistem, dan pengujian sistem, sedangkan metode yang digunakan adalah metode Topsis yang menggunakan 4 kriteria yakni; Peruntukkan, Jarak, Jumlah Kubik yang dipesan, dan Prediksi Jumlah pemakai. Peneliti memilih metode TOPSIS agar penentuan alternatif antara jarak ideal positif dan negatif lebih optimal. Hasil dari penelitian ini merupakan sistem pendukung keputusan pendistribusian air bersih PDAM  yang berbasis web yang memudahkan penentuan prioritas  penyaluran air bersih kepada masyarakat.

 

Abstract

PDAM Makassar City is a regional company assigned to manage the fulfillment of clean water needs for citizens of Makassar City. Currently, the distribution of clean water still has not fully covered the entire area of Makassar City.  The major causes of this situation is a dramatic decrease of the water debit in certain time. To overcome this problem, the government of Makassar city through PDAM, distributes water by direct delivery to the resident's houses using tank trucks.  The process of channeling water from PDAM has difficulty in determining priority areas of delivery due to lack of the fleet. This research consists of  four stages, namely: recognition of problems, data collection, system design, and system testing. While for the algorithm using the TOPSIS method that incorporate four criterias including the allotment, distance, amount of cubic, as well as predicted number of users. The  TOPSIS method is chosen since the determination between the positive and negative ideal distances is more optimal. The results of this study is a web-based decision support system for clean water distribution of PDAM that helps to determine the priority of clean water distribution to the community in Makassar.
Natural Disasters and Birth Rate: Evidence from the 2010 Chilean Earthquake
Authors:   Escuela de Ingeniería Comercial, Universidad de Valparaíso, Chile, Scapini Valeria , Vergara Cinthya ,   Departamento Ingeniería Industrial, Universidad de Chile, Chile
Published: February 2021

A major natural disaster can generate changes in the affected population’s behavior. As Chile is considered one of the countries with the highest seismic activity and has experienced several of the most intense earthquakes on record in the world, this work seeks to identify behavioral changes in the birth rate within an affected population related to a natural disaster in Chile. Based on evidence from the 2010 Chilean earthquake, an empirical study was carried out drawing on birth rate data and social data associated with earthquakes in Chile between 2004 and 2015. Two models were estimated. The first model is a difference-in-differences model for determining the effect of the disaster on the birth rate in the affected area in the post-disaster period. The second model is a triple-difference model that includes the trend of the data over time. The results indicate a positive relationship between the variation in the birth rate and the occurrence of the natural disaster. Studying the relationship between disaster events and fertility contributes to understanding the phenomena of social dynamics. This knowledge could improve public policy decision making for better planning in the face of a natural disaster.
KOMODITAS PADI: TELAAH KEHILANGAN HASIL SAAT PANEN DI KABUPATEN JOMBANG
Authors: Hidayat Syarif Imam , Parsudi Setyo , Putri Gerin Lingga Ayu Mustika
Published: February 2021

The research was conducted in Mojowarno District, Ngoro District and Peterongan District, Jombang Regency, from March to April 2020, in the rice field area. The aim of this research is to calculate the amount of yield loss and the value of the loss, to analyze the factors that influence the loss of yields, the efforts and strategic actions of farmers and the government to reduce yield losses. The missing results in this study include: harvesting, heaping, threshing, and drying activities. The research method used is descriptive quantitative method with the respondent determination technique using quota sampling of 75 people who are farmers in three sub-districts of Jombang Regency. The analysis technique used is the method of calculating the amount of loss and loss value (Riska, 2016), multiple linear regression, classical and descriptive assumption tests. The results of the study showed that the yield loss per hectare was 12.7% and the loss value was Rp.5,945,386.2, - Through the multiple linear regression method, it was found that there was a significant influence on land area, harvest age, farmer behavior, varieties, tools and the method of harvesting, thresher tools and the season for the loss of crop yields of 70.9% and the remaining 20.1% are other factors not examined. Strategic efforts that can be made for farmers are to use wholesale harvesting power, harvest on time, reduce threshing of grain at home, reduce the use of easy-to-fall rice varieties and reduce collection before threshing. For the government, this can be done by increasing the capacity and skills of farmers (capacity building), utilizing appropriate technology according to location, forming and empowering farmer groups.
Saúde mental dos estudantes universitários
Authors: Da Silva Maria Eduarda Alves , Dos Santos Rayza Rodrigues , Medeiros Roberta Vanyhellen de Jesus , Souza Sandiely Lorrainy de Carvalho , Souza Dagmar Fonseca , Ferreira Deuzileni Pereira Vieira
Published: February 2021

O objetivo deste estudo é analisar a produção de artigos científicos no período de 2010 a 2020 referentes aos principais problemas de saúde mental apresentados por estudantes universitários e o que os leva a desenvolvê-los. Trata-se de uma revisão integrativa da literatura sobre o tema proposto. Para obtenção dos dados, foram utilizadas as bases de dados Scientific Eletronic Library online (SCIELO), Biblioteca Virtual de Saúde (BVS), Plataforma de educação básica (CAPES) e PubMed. Os resultados indicaram que de fato a vida acadêmica interfere na saúde mental dos estudantes e estes são identificados como um grupo vulnerável e de risco nas categorias de ansiedade, depressão e uso de drogas, e essas condições são pontos fundamentais para o desenvolvimento de ações em saúde mental. É necessário que a instituição de ensino superior desenvolva estratégias para prevenir agravos a saúde mental de seus discentes, para que assim possam concluir o ensino superior com saúde mental estável.
Utero-relaxing and anti-free-radical effects of hydro-ethanolic extracts of Desmodium ramosissimum in the wistar female rats
Authors: Madjalani Hèzouwè , Metowogo Kossi , Pakoussi Tcha , Nabede Aklesso , Kanabiya Essodjolon , Melila Mamatchi , Eklu-Gdegbeku Kwashie , Aklikokou Kodjo A.
Published: February 2021

Objectives:

In sub-Saharan Africa, the therapeutic use of medicinal plants is of arousing interest. Reproductive disorders are a public health problem like everywhere else in the world. The population, especially in rural areas, uses medicinal plants for their beneficial effects. In Africa, the population uses these medicinal plants for their healthcare, including solving problems related to childbirth where there is an increase in the number of women known as “traditional birth attendants.” The effects of its medicinal plants relate to the various reproductive processes in women, from pregnancy to induction of labor, elimination of placental retention, and management of postpartum hemorrhage. To contribute to the enhancement of medicinal plants traditionally used in reproductive healthcare in Togo and to make information on their pharmacological effects available to the population, this work focused on the evaluation utero-relaxing and anti-free radical effects of extracts of Desmodium ramosissimum in the female rats of the Wistar strain.

Material and Methods:

The effects of hydro-ethanolic extracts of leaves, stem barks, and roots of D.ramosissimum were then tested on shreds Myometer of the female rats mounted in an organ vat and the antioxidant activity of these extracts tested was then determined.

Results:

The results show that hydro-ethanolic extracts from leaves, stem bark, and roots of D.ramosissimum cause a reduction in the frequency of spontaneous contractions of the uterine muscle. This reduction shows that these extracts have relaxing effects on the contraction of this muscle. The leaves extract showed better antioxidant activity compared to other extracts.

Conclusion:

This antioxidant activity is probably due to the phenolic constituents and its metabolites would be partly responsible for the pharmacological activities of D.ramosissimum. D.ramosissimum could thus be used to reduce uterine contractions in order to avoid Threats of Premature Labor.
Bioethical aspects of DNA testing of inherited hearing disorders in Yakutia
Authors: Чердонова А.М. , Пшенникова В.Г. , Соловьев А.В. , Кузьмина С.С. , Романов Г.П. , Кононова С.К. , Федорова С.А. , Барашков Н.А.
Published: February 2021

В работе представлены результаты исследований биоэтических проблем, которые могут возникнуть при массовом внедрении ДНК-тестирования на наследственные нарушения слуха.

In this work, the main range of bioethical problems that may arise during the mass introduction of DNA testing for hereditary hearing disorders are defined.
The assessment of ethical aspects of the genetic counseling efficacy in Russian Federation
Authors: Баранова Е.Е. , Зобкова Г.Ю. , Ижевская В.Л.
Published: February 2021

Цель исследования: выявить этические проблемы, возникающие в процессе медико-генетического консультирования при использовании современных методов генетического тестирования (полногеномный анализ, расширенный скрининг носителей мутаций). Для исследования была разработана анкета, позволяющая оценить социально-демографические и профессиональные характеристики врача и содержащая вопросы и ситуационные задачи по основным этическим проблемам. В анкетировании приняло участие 30 специалистов разных специальностей, связанных с медицинской генетикой. При назначении генетических тестов врачам было важно помочь супружеским парам иметь здоровых детей. Большинство респондентов считали, что до вступления в брак ответственные люди должны знать, не являются ли они или их партнеры носителями мутаций, приводящих к наследственным заболеваниям, которые могут быть переданы детям. Также большая часть респондентов высказала согласие с необходимостью обязательного скрининга на носительство мутаций наиболее частых моногенных заболеваний и неонатального скрининга на миодистрофию Дюшенна и спинальную мышечную атрофию. Кроме того, специалисты поддерживают необходимость создания этического кодекса врачей-генетиков. В данном пилотном исследовании были выявлены основные векторы этических проблем специалистов медико-генетического профиля, которые требуют углубленного изучения в последующих более масштабных исследованиях.

The study aim was to identify ethical problems arising in the process of genetic counseling while using modern methods of genetic testing (WGS, extended carrier screening). A special questionnaire was developed to assess the ethical dilemmas and attitudes of doctors working in the field of medical genetics. The questionnaire consists of 28 complex questions and contains a general part that allows you to evaluate the socio-demographic and professional characteristics of the doctor. The survey was attended by 30 specialists. For doctors it was important to help married couples have healthy children while prescribing genetic tests. The majority of the respondents believed that before marriage, responsible people should know if they or their partners are carriers of mutations that lead to inherited diseases that can be passed on to children. Also, most of the respondents agreed with the need for mandatory screening for the carriage of mutations in the most common monogenic diseases and neonatal screening for Duchenne muscular dystrophy and spinal muscular atrophy. In addition, experts support the creation of an ethical codex for geneticists. In this pilot study, the main vectors of ethical problems of medical and genetic specialists were identified, which require in-depth study in subsequent larger studies.
Familial Mediterranean Fever (FMF) and Pregnancy: Literature Review
Authors: Соцкий П.О.
Published: February 2021

В обзоре обобщается текущая информация о влиянии семейной средиземноморской лихорадки (ССЛ) и ее лечения на исходы беременности, анализируется вопрос гипотетической тератогенности колхицина. В случае резистентности/непереносимости колхицина обсуждается возможность использования других лекарственных средств во время беременности, в том числе, генно-инженерных биологических препаратов, среди которых при ССЛ наиболее предпочтительны ингибиторы интерлейкина 1. Представлена эволюция взглядов на необходимость проведения пренатальной диагностики хромосомных аномалий плода пациенткам с ССЛ, получающим колхицин во время зачатия и беременности, а также в тех случаях, когда колхицинотерапия проводилась мужьям во время зачатия их женами. Акцент сделан на аспектах безопасности терапии, основные положения которых представлены в клинических рекомендациях по лечению ССЛ Европейской антиревматической лиги (EULAR,2016). Согласно этим рекомендациям, прием колхицина не должен быть прекращен во время зачатия, беременности или лактации; имеющаяся на сегодняшний день доказательная база не подтверждает необходимость выполнения амниоцентеза.

The review summarizes current information on the impact of FMF and its treatment on pregnancy outcomes, and analyses the hypothetical teratogenicity of colchicine. In the case of colchicine resistance/intolerability, the possibility of using other drugs during pregnancy, including genetically engineered biological drugs, among which interleukin 1 inhibitors are preferred for FMF. An evolutionary view is presented on the need for amniocentesis in FMF patients receiving colchicine during conception and pregnancy, as well as in cases where colchicine therapy was performed to husbands during conception with their wives. Emphasis is placed on the safety aspects of therapy, the main provisions of which are presented in the clinical recommendations for the treatment of FMF of the European Anti-Rheumatic League (EULAR, 2016). According to these recommendations, colchicine should not be discontinued during conception, pregnancy or lactation; today’s evidence does not support amniocentesis.
Frequency of Y chromosome microdeletions in Armenian infertile men
Authors: Шахсуварян Г.Р. , Караханян Р. , Саркисян Т.Ф. , Ижевская В.Л.
Published: February 2021

Микроделеции длинного плеча Y-хромосомы являются частой генетической причиной мужского бесплодия, связанного с азооспермией и олигозооспермией. В различных этнических группах частота встречаемости микроделеций Y-хромосомы может существенно варьировать, а их спектр иметь определенные особенности. Целью представленного исследования являлось определение частоты и структуры микроделеционных изменений локуса AZF у мужчин армянской национальности с бесплодием для оптимизации диагностических и лечебных мероприятий с применением вспомогательных репродуктивных технологий.

The long arm of the Y chromosome microdeletions are common genetic cause of male infertility, related with azoospermia and oligozoospermia. The frequency of various Y-chromosome microdeletions can vary significantly in different ethnic groups and have certain features. The aim of the presented research is to determine the frequency and spectrum of AZF (azoospermia factor) microdeletions in infertile men of Armenian nationality, in order to optimize diagnostic and therapeutic measures using assisted reproductive technologies.
Analysis of the genetic architecture of preeclampsia in the context of evolutionary medicine
Authors: Сереброва В.Н. , Трифонова Е.А. , Степанов В.А.
Published: February 2021

В настоящем исследовании впервые применен эволюционный подход к изучению генетической архитектуры преэклампсии (ПЭ) по системе регуляторных однонуклеотидных полиморфных вариантов (rSNP) дифференциально экспрессирующихся генов (ДЭГ), выявленных благодаря анализу транскриптома плаценты. Полученные результаты демонстрируют значимую роль 10 rSNP 8 ДЭГ и их адаптивных изменений на макроэволюционном и/или микроэволюционном уровне в формировании наследственной подверженности к ПЭ у русских и якутов.

In this research first applied evolutionary approach to study of the PE genetics architecture via the regulatory polymorphic variants (rSNPs) of differentially expressed genes (DEG), identified by analysis of the transcriptome in placental tissue. The results demonstrate а significant role of 10 rSNP 8 DEG and their adaptive changes at the macroevolutionary and/or microevolutionary level in the formation of hereditary predisposition to PE in Russians and Yakuts.
The frequency of immune system genes polymorphisms associated with idiopathic form of recurrent miscarriage in Kazakh population
Authors: Муртазалиева А.В. , Святова Г.С. , Березина Г.М.
Published: February 2021

Казахская популяция по частотам полиморфных вариантов генов иммунной системы занимает промежуточное положение между популяциями Европы и Азии. Анализ частотного распределения исследованных генотипов в популяции казахов показал их соответствие равновесию Харди-Вайнберга (p>0,05). В связи с высокой частотой идиопатического привычного невынашивания беременности (иПНБ) в популяциях человека, ее вкладом в показатели репродукции поиск возможные генетические факторы развития данной патологии актуален. Изученные полиморфизмы генов иммунной системы могут вносить вклад в ее развитие, что требует проведения дальнейших исследований для определения их значимости в развитии иПНБ в казахской популяции.

Kazakh population compares with populations of Europe and Asia by the immune system genes occupies in intermediate position. Frequency distribution analysis of the studied genotypes in the Kazakh population showed their correspondence to Hardy-Weinberg equilibrium (p> 0.05). Due to the high frequency of idiopathic form of recurrent miscarriage (iRM) in human populations, its contribution to reproduction rates, studied immune system genes polymorphisms can be considered as possible genetic factors for the development of this pathology; conduct further research to determine their significance in the development of iRM in Kazakh population.
Molecular bases of primary monogenic dyslipidemia
Authors: Иванова О.Н. , Васильев П.А. , Захарова Е.Ю.
Published: February 2021

Дислипидемия - одно из наиболее распространенных метаболических нарушений, доминирующий фактор риска заболеваний сердечно-сосудистой системы. Своевременная диагностика и корректировка липидного профиля могут заметно снизить заболеваемость и смертность от сердечно-сосудистых заболеваний. Обширная гетерогенная группа заболеваний приводит к устойчивым изменениям липидного профиля. Предлагаемый обзор включает в себя описание метаболизма липидов, молекулярных основ и клинических характеристик первичных моногенных дислипидемий. Мутации двадцати пяти генов являются причиной большинства моногенных дислипидемий. На основании изменений липидного профиля выделяют пять групп фенотипов с экстремальным отклонением уровней маркеров липидного профиля: с высоким и низким уровнем липопротеинов низкой плотности, с высоким и низким уровнем липопротеинов высокой плотности, с высоким уровнем триглицеридов. Для каждого фенотипа обозначены ассоциированные гены, указан ген с чаще всего выявляемыми мутациями. Подробно описаны молекулярные основы наиболее распространенной дислипидемии, характеризующейся существенным повышением уровня липопротеинов низкой плотности - семейной гиперхолестеринемии. Генетическое тестирование пациентов с дислипидемией дает возможность постановки точного диагноза, каскадного обследования и консультирования членов семьи пациента, ранней диагностики для предотвращения или более позднего проявления осложнений.

Dyslipidemia is one of the most common metabolic disorders, the dominant risk factor for diseases of the cardiovascular system. Timely diagnosis and correction of the lipid profile can significantly reduce morbidity and mortality from cardiovascular diseases. An extensive heterogeneous group of diseases leads to persistent changes in the lipid profile. This review includes a description of lipid metabolism, the molecular basis, and clinical characteristics of primary monogenic dyslipidemia. Mutations in twenty-five genes are responsible for most monogenic dyslipidemias. On the basis of changes in the lipid profile, five groups of phenotypes are distinguished with extreme deviation in the levels of lipid profile markers: with high and low levels of low density lipoproteins, with high and low levels of high density lipoproteins, with high levels of triglycerides. For each phenotype, the associated genes are indicated, the gene with the most frequently detected mutations is indicated. The molecular basis of the most common dyslipidemia, familial hypercholesterolemia, is described in detail. Genetic testing of patients with dyslipidemia makes it possible to make an accurate diagnosis, the possibility of cascade examination and counseling of the patient’s family members, the possibility of early diagnosis to prevent or later manifest complications.
The linkage between the level of medical genetics learning and the professional plans of students
Authors: Балашова М.С. , Субботина Т.И. , Филиппова Т.В. , Литвинова М.М. , Тулузановская И.Г. , Чебеляев И.Ю. , Жученко Н.А. , Асанов А.Ю.
Published: February 2021

Методом анкетирования были оценены взгляды двух групп студентов Сеченовского университета (учащиеся 4 курса лечебного факультета и участники студенческого научного кружка (СНК) по медицинской генетике) на планируемое послевузовское образование и на роль генетики в профессиональной и личной жизни опрошенных. Выявлено более глубокое понимание терминов, касающихся современных генетических технологий у студентов, посещающих СНК. Профессиональные планы данной группы также заметно отличаются от планов студентов, не посещающих СНК.

А survey-based study of two groups of Sechenov University students was conducted to evaluate the attitude to the career planning and the role of genetics in the professional and personal life of the respondents. The first group included 4th-year students of the general medicine faculty and the second group included participants of the medical genetics scientific club. A deeper understanding of terms related to modern genetic technologies was revealed among students attending the scientific club. The professional plans of this group of students also differ markedly from those of students who do not attend the scientific club.
Genetic education of medical teachers and students
Authors: Горбунова В.Н.
Published: February 2021

Предлагается новый подход к повышению квалификации по генетике врачей, преподавателей и студентов медицинских вузов, основанный на использовании дифференцированных учебных программ для специалистов различных медицинских профилей.

New approach is proposed for genetic education of physicians, medical teachers and students based on differentiated training programs for different medical type specialists.
On the issue of the need to improve the teaching of medical genetics in medical higher educational institutions
Authors: Григорьева Ю.О. , Захарова О.М. , Сафина Н.Ю. , Яманди Т.А. , Есакова А.П. , Акуленко Л.В.
Published: February 2021

При переходе к персонализированной медицине и высокотехнологичному здравоохранению освоение любой клинической дисциплины в системе высшего медицинского образования немыслимо без знаний основ и последних достижений медицинской генетики. Организация поэтапного изучения медицинской генетики на старших курсах медицинских ВУЗов позволит готовить более квалифицированных врачей, готовых перейти от стандартизованной к персонализированной медицине.

With the transition to personalized medicine and high-tech healthcare, mastering any clinical discipline in the system of higher medical education is unthinkable without knowledge of the basics and the latest achievements of medical genetics. The organization of a step-by-step study of medical genetics in the senior years of medical universities can provide an opportunity to train more qualified doctors who are ready to move from standardized to personalized medicine.
Experience of course works using cell culture technologies of classical cytogenetics
Authors: Комкова Г.В. , Королев В.А. , Железнова М.А.
Published: February 2021

В статье обобщается опыт написания курсовых работ по разделу цитогенетики и освоения основных методик культивирования, приготовления и окрашивания хромосомных препаратов студентами на кафедре биологии, медицинской генетики и экологии КГМУ.

The article summarizes the experience of writing course works on cytogenetics and mastering the basic methods of cultivation, preparation and staining of chromosomal preparations by students at the Department of Biology, Medical Genetics and Ecology of KSMU
The experience of organizing the pedagogical process at the Department of Medical Genetics of the Siberian Medical University (Tomsk)
Authors: Салюкова О.А. , Фонова Е.А. , Яковлева Ю.С.
Published: February 2021

В данной статье идет речь об особенностях и опыте преподавания медицинской генетики для студентов, ординаторов и врачей различных специальностей.

This article is about the features and experience of teaching medical genetics for students, residents and doctors of various specialties.
The use of Problem Based Learning in Improving Students’ Learning Achievement
Authors: Agustiningrum Etty
Published: February 2021

This research was aimed at improving student learning outcomes in IPS subject on 7th grade SMP N 4 Pontianak. The research was using Problem Based Learning method. It used descriptive method with qualitative design. It was implemented through 2 cycles, in which each cycle consisted of four steps such as planning, acting, observing, and reflecting. The data collecting techniques used in this research were direct observation and students’ learning outcomes. Based on the result of analysis showed that there was an improvement in learning activity in the first cycle as 60% meanwhile the second cycle showed 71%. The student outcomes at the first cycle showed 56% and the second cycle improved to be 76,5%.
The use of Student Team Achievement Division (STAD) in Improving Students’ IPS learning achievement of Class IX F SMP N 21 Pontianak
Authors: Jumadi Jumadi
Published: February 2021

This classroom action research aimed at improving learning quality and student learning achievement that are still low especially in the IPS learning process in class IX F of SMP Negeri 21 Pontianak. To overcome these problems, the cooperative method of Student Teams Achievement Division (STAD) was used. After applying the Student Teams Achievement Division (STAD), the students’ IPS learning achievement in class IX F was increased. This study was conducted in two cycles of 38 students. The technique of collecting data was through observation conducted by teachers and collaborators, and data analysis was carried out in descriptive with percentage techniques. The level of student and teacher activity stated as a very good, good, or moderate category. while the success of using the Student Teams Achievement Division (STAD) method was stated successfully, less successfully, or unsuccessfully.Based on the results of the research that had been done, it can be concluded as follows: 1) Student activity in the teaching and learning process was good because it had reached the specified criteria in which 81% of students were actively involved, 2) Teacher activities in learning process was very good because it reached 84%, 3) While the students’ learning achievement percentage reached 82% beyond the criteria of 75%. Thus, the use of the cooperative method of Student Teams Achievement Division (STAD) succeeded in improving student learning achievement in IPS learning in class IX F of SMP Negeri 21 Pontianak
Pengendalian Sosial Penggunaan Smartphone Anak Bersekolah Di Madrasah Aliyah Babussalam Desa Peniraman
Authors: Sulaiman Sulaiman
Published: February 2021

This thesis is entitled: social control by parents in the use of smartphones in children who are still in school at Madrasah Aliyah Babussalam Peniraman Pinyuh River District. The general problem of this research is social control by parents in the use of smartphones in children who are still in school at Madrasah Aliyah Babussalam Peniraman Pinyuh River sub-district. Sub problem in this research is 1: How persuasive social control by parents of children in the use of smartphones 2: How repressive social control by parents of children in the use of smartphones 3: How curative social control by parents of children in the use of smartphones. This study used a qualitative approach with descriptive methods. Observation data collection techniques, interviews and documentation study with data collection tool guide observation, interviews, books and archival records. Informal in this study are the parents and children. The positive impact for children to use the smartphone as to facilitate the child to seek material from school assignments, and berkomonikasi. But the negative impact of such children concentrate less on learning, lazy learning. The results of this research show that parents have been doing social control in children berifat persuasive, repressive and curative. But the negative impact of such children concentrate less on learning, lazy learning. The results of this research show that parents have been doing social control in children berifat persuasive, repressive and curative. But the negative impact of such children concentrate less on learning, lazy learning. The results of this research show that parents have been doing social control in children berifat persuasive, repressive and curative.
Dampak Pembangunan Wisata Hutan Mangrove Di Pasir Panjang, kecamatan Mempawah Hilir, Kabupaten Mempawah
Authors: Riyanto Richard Septhrus , O E Sawitri
Published: February 2021

The purpose of this research is to study, titled Impact of tourism development in the village of Sand Mangrove Park, District Mempawah Hilir Regency Mempawah. With the problem of how the form of livelihoods, theeconomic condition of the community after the development, and social relations that exist around mangrove forest tourism. This research method is a qualitative research approach. This type of research is a case study. The words and actions of the person being interviewed or observed are the main data sources. The main data sources are recorded through written records or through video / audio tapes recording, taking photos or films. Data collection techniques used were interviews, observation, and study of documentation. Analysis of the data used is data reduction, data presentation, and drawing conclusions. The results showed that: The impact of social change in terms of livelihoods and economic conditions is very beneficial to the community because of the development of the mangrove park tourism can increase people's income and livelihood of the community also increased where the livelihood of the community initially farmers or fishermen can also workas parking attendants, traders or crossing services and in terms of social relations also the community in the area is very good.
SUPPLY AND DEMAND FACTORS OF THE STATE AND BUSINESS ON PUBLIC AND PRIVATE PARTNERSHIP
Authors: Tischenko T. V.
Published: February 2021

The subject of the study is public–private partnership (hereinafter – PPP) mechanisms in the modern economy of the Russian Federation. The article considers economic factors affecting the demand for PPP mechanisms in Russia from the state and business. The paper carries out a comparative assessment of the supply and demand of PPP and alternative mechanisms of interaction between the state and business. The study reveals that PPP does not have significant advantages in comparison with traditional public procurement or leasing. According to the results of the study, the author makes a forecast that in the near future we should expect a significant reduction in the volume of private and public co-financing of projects implemented on the basis of PPP. Assumption by state additional obligations to finance projects in the absence of budget restrictions can increase the demand for PPP on the part of business.
MODERN APPROACHES TO THE ORGANIZATION OF FINANCIAL SUPPLY OF THE ARMED FORCES OF THE KYRGYZ REPUBLIC
Authors: Bekishov R. Sh.
Published: February 2021

The article performs an analytical review on the issues of reforms in the state structure of the Kyrgyz Republic and its military organization. The paper considers military reform as a necessary component of political and socio-economic reforms, one of the determining conditions for their success, an effective factor in ensuring the defense and security of Kyrgyzstan, its active and constructive role in the modern world. The author notes the necessity, from the point of view of the defense interests of Kyrgyzstan, in the development and adoption of fundamentally new methods of organizing the financial support of the Armed Forces of the Kyrgyz Republic. At the same time, the created mechanism of the organization should be aimed, first of all, at optimizing the size and structure of the Armed Forces, their compliance with the financial, economic, scientific, technical and other capabilities of the country to ensure its military security with the least expenditure of resources.
THEORETICAL AND METHODOLOGICAL FOUNDATIONS OF SOCIO-POLITICAL ANALYSIS OF DIGITAL PROTEST ACTIVITY
Authors: Tanina M. A. , Yurasov I. A. , Yudina V. A. , Zyablikova O. A.
Published: February 2021

The analysis of various forms of protest activity in the virtual space becomes especially relevant in the era of digital technologies development in all spheres of public life. But until now, there has not been a comprehensive work devoted to the trends that cause, accompany and organize digital protest activity in the world. The purpose of this paper is to determine the theoretical and methodological foundations of the socio-political analysis of digital protest activity in modern societies. The study solved the problems of analyzing the values of provincial Russian societies, institutional matrices, network political management and specific forms of virtual communication in the network space. The authors reveal the theoretical and methodological foundations of the development of digital protest activity in the world: features of social temporality, public values, specifics of trust, types of social connections in urban space; digitalization, virtualization and mediativization, information inequality, digital elitism; institutional matrices and institutional traps of electronic communication, trends in digital management. The theoretical grounds provided are the basis of digital simulation of the protest activity in Megacities and provincial towns.
APPLICATION OF TESTING TECHNOLOGY IN PROGRAM TRAINING
Authors: Makarenko A. E.
Published: February 2021

The purpose of the paper is to improve the methods of using test technologies in the educational process and to develop an optimal schedule for conducting tests in higher education when teaching programming languages. The article considers the advantages and disadvantages of test technologies. The author investigates the effectiveness of one-time and step-by-step testing and studies the role of testing at different stages of the educational process. In the course of the study, the author used written and computer forms of testing. The paper shows that step-by-step testing is more effective than one-time testing. The article identifies the expediency of testing that precedes the implementation of practical work. The results of the study allow us to develop an optimal schedule for conducting tests, which contributes to improving the quality of learning material and increasing students’ motivation.
JUSTIFICATION OF THE STRUCTURE OF A SET OF MODELS FOR THE DEVELOPMENT AND IMPLEMENTATION OF REGIONAL PROGRAMS, TAKING INTO ACCOUNT ASSOCIATED RISKS
Authors: Denisova A. I.
Published: February 2021

The subject of the study is Federal programs of socio-economic development of the regions of the Russian Federation. The paper considers the computational and analytical tools for the development and implementation of support for development programs and shows the need for its improvement. The author presents the structure of the corresponding software in the form of a model complex for the formation and evaluation of regional development program options. The article gives the main indicators necessary for calculations. The study considers the methods of obtaining data for the formation, correction, and evaluation of the implementation of programs. The author proposes the scenario modeling apparatus as a tool for variable calculations to justify stable and satisfactory planning solutions. The article justifies the necessity of taking into account the impact of risks in the process of forming and implementing the program and proposes methods of their accounting. The paper proposes to use an ontological model for organizing the storage and presentation of information about the sources and consequences of risks.