EFFECT OF STATIN USE ON STATUS OF DIABETIC ETINOPATHY/ DIABETIC MACULAR EDEMA IN PATIENTS OF TYPE 2 DIABETES MELLITUS
Authors: Kumar Singh Lokesh , Gupta Alka , Srivastava Jigyasa 
Published: October 2021

AIM:
Effect of statin use on status of diabetic retinopathy /diabetic macular edema in patients of type 2 diabetes mellitus
Check the lipid profile and detail fundus examination of all patients included in study.
Effect of lipid lowering agents (statin) on Diabetic retinopathy.
Asses the changes in fundus of DME patients after giving statin.
MATERIALS AND METHODS:-
A prospective study was conducted in the OPD of upgraded department of ophthalmology at LLRM Medical College,
Meerut over the duration of from July 2019 to June 2020.
The proposed study was in association of status use and hyper triglyceridemia with diabetes macular edema in patients
with type-2 diabetes and diabetic retinopathy. Clearance from institution ethics committee was obtained before the
study was started.
An informed consent was obtained from all the patients before including them in to the study.
A total of 86 patients were divided in to two equal groups randomly
RESULTS:-
A prospective study was conducted in the OPD of upgraded department of ophthalmology at LLRM Medical College,
Meerut over the duration of from July 2019 to June 2020 and sample size of patients taken was 86
About 70.9% of the patients in this study were males and 29.1% were females.
About 26.7% of the study subjects in this study had diabetes mellitus since 16 – 20 years,25.6% since more than 20 years
and 20.9% since 11 – 15 years.
During the baseline the CSME in left eye was present in 24.4% of the cases and during follow up,the CSME was present in
10.5% of the cases .
At the time of baseline,about 64% of the patients had no CSME in right eye and 36% had CSME.At the time of follow up
87.2% of the cases had no CSME and 12.8% had CSME.
In mild NPDR during follow up,44.2% had mild NPDR,24.4% had moderate NPDR and 8.1% had severe NPDR at baseline.
About17.4%ofthepatientswhohadmoderateNPDRatbaselinealsohadmoderateNPDRduringfollowupvisits inlefteye.
Among all the patients with mild NPDR during follow up, 54.7% had mild NPDR, 22.1% had moderate NPDR and 10.5%
had severe NPDR during baseline. About 12.8% who had moderate NPDR during baseline also had moderate NPDR
during follow up in right eye
Mean cholesterol level during baseline was 154.13 mg/dl and during follow up was 138.12 mg/dl which was statistically
significant (p=0.000).
The mean triglyceride level during the baseline was 178.37 mg/dl and during follow up was 156 mg/dl which was
statistically significant between the two groups (p=0.000).
Mean LDL cholesterol level during the baseline was 94.99 mg/dl and during follow up was 61.24 mg/dl which was
statistically significant between baseline and follow up (p=0.000).
This study had shown improvement of visual acuity,decrease in macular edema and progression of diabetic retinopathy.
The study also revealed that ,the statins are effective in decreasing the total cholesterol, LDL cholesterol, and
triglycerides.
CONCLUSION:-
This study had shown improvement of visual acuity,decrease in macular edema and progression of diabetic retinopathy
in patients whom statins was given
The study also revealed that,the statins are effective in decreasing the total cholesterol(mean value during baseline was
154.13 mg/dl which reduces to 138.12 mg/dl during follow up),LDL cholesterol (mean value reduces from 94.99 mg/dl
during baseline to 61.24 mg/dl during follow up)and triglycerides (mean value during baseline 178.37 mg/dl to 156
mg/dl during follow up).as given.