bluuebunny/crossref_metadata_2025 huggingface dataset:
Legal responsibility without offense and state coercion is doctrinal and practical nonsense (Directly about the empty — Directly about the empty). Review of the monograph by V. M. Baranov “ʺPositive legal responsibilityʺ: controversial concept, imaginary practice, virtual technique” (Moscow: Blok-Print Publ., 2022. 176 p.)
Authors: Polyakov Sergey
Published: July 2022

Polyakov S. B. Legal responsibility without Infringement and state coercion is Doctrinal and Practical nonsense (Directly about the empty — Directly about the Empty). Review of V. M. Baranov’s monograph “ʺPositive legal responsibilityʺ: controversial concept, imaginary practice, virtual technique” (Moscow: Blok-Print Publ., 2022. 176 p.).
On the use of information and materials obtained in the course of operational investigative activities to prove the truth in a criminal case
Authors: Abdullaev Yamudin , Miller Viktor
Published: July 2022

The modern russian doctrine of criminal procedural evidence includes a ban on the use of the results of operational investigative activities in proving. It is based on the ideology of the investigator as a subject of proving objective truth. The investigator is authorized by means of investigative actions to turn the results of operational investigative activities into means of proving the truth. In the accusatory criminal procedure system, information and materials received by both parties are transformed into a means of proving the truth only after cross-checking. As the Italian experience shows, the transition from the investigative system to the accusatory criminal procedure system and the adversarial technology of proving the judicial truth is inevitable in the context of building a rule of law and democracy.
Technologies for the formation of criminal procedural evidence
Authors: Vlasova Svetlana
Published: July 2022

The article analyzes a concept that is fashionable in the modern Russian theory of criminal procedural evidence and explains the patterns of formation of criminal procedural evidence as a means of proof. One of the main such patterns, according to the author, is the relationship of a certain technology for the formation of evidence with the type of prosecution. The investigative form of bringing forward a public, as well as a private-public accusation, determines the investigative technology of proof. The transition to an accusatory system will make the technology of forming evidence in a criminal court adversarial.
Social content of the systemic struggle against drug business
Authors: Iudin Alexander , Serafimov Mikhail , Shpilev Dmitry
Published: July 2022

The article considers the experience of combating drug addiction in the late 90-s — early 2000-s by the example of the city district of Bor. The uniqueness of this experience is that the city for a short time has become the regional center for the sale of drugs, so the correction of the situation required not only substantial financial investments, the use of innovative approaches, but also collective efforts of all interested parties
Analysis of approaches to systems of indicators characterizing the financial stability of an economic entity
Authors: Bardakov Artem , Kornilov Dmitry
Published: July 2022

The article provides an overview of various approaches to the analysis of the financial and economic activities of an organization in order to identify the negative dynamics of its financial stability. Based on the generalization of different methods of financial analysis, a schematic classification of the most effective approaches is presented. It is concluded that it is expedient to use different-criteria approaches to assessing financial stability, taking into account the interpretation of information about the financial condition of an economic entity, depending on the goals of the analysis and the category of users using its results.
Counteraction to legalization (laundering) of proceeds from crime: international legal aspect
Authors: Chuprova Antonina
Published: July 2022

This article discusses the main aspects of the legal regulation of counteracting the legalization (laundering) of illegally obtained income in national and international legislation, and also draws a correlation between US and EU legislation in this area. As a result, of the study, conclusions were drawn about various approaches and principles for the formation of legal mechanisms aimed at preventing the legalization of proceeds from crime.
PEMETAAN POTENSI WISATA, PELUANG DAN TANTANGAN PENGEMBANGAN DESA WISATA PENGADANGAN BARAT, KABUPATEN LOMBOK TIMUR
Authors: Hadi Marham Jupri , Lume Lume , Widyaningrum Meiyanti
Published: July 2022

Pengadangan Barat Village has been designated as a tourist village in 2021, however it has not shown its existence as an attractive rural tourist destination to visit upto the present. This is due to the absence of a master plan for the development of tourism. This study aimed to map the tourism potential of Pengadangan Barat Village as well as the opportunities and challenges of its development into a village-based tourist destination. Using qualitative research method, this research involved the village government, members of tourism awareness groups, and village communities to become informants. Data were collected through participant observation techniques, FGDs, interviews and documentation and were analyzed qualitatively. This research revealed three categories of tourism potential owned by the Pengadangan Barat tourism village, namely natural potential, cultural and historical potential, and human resource potential. This research also concluded that western tourism villages can be developed into destinations for educational tourism, agritourism and sports or adventure tourism. The challenges of developing this village were  in the form of the capacity of members of tourism awareness groups, village government policies, community participation and competition with other tourism villages. These challenges could be addressed by conducting intensive communication and cooperation with various relevant parties and asking for assistance from practitioners and academics.
PENGEMBANGAN POTENSI WISATA DI DESA WISATA SIDOREJO KECAMATAN LENDAH KABUPATEN KULON PROGO
Authors: Kusuma Pangky Arbindarta , Salindri Yerika Ayu
Published: July 2022

The objective of this research is to identify the potential attraction of the Sidorejo Tourism Village located in Lendah District, Kulon Progo Regency. In identifying, the researchers used several methods both in collecting data and processing data. Steps to collect data include FGD, interviews, observations, library studies and documentation, while the primary and secondary data processing obtained was carried out by descriptive-qualitative analysis, interpretation and analysis of tourism potential. It is resulted that Sidorejo Tourism Village has a various attractions including natural, cultural and artificial attractions. It is known that there are several problems in management and become quite influential obstacles related to the structure of management, management, education level and packaging of tourism products.
ЭЛЕКТРОННЫЙ МАРКЕТИНГ И ЕГО СТРАТЕГИИ
Authors: Хагаева А.В. , Костоева А.А.
Published: July 2022

В данной статье рассматривается тема электронного маркетинга, его стратегий и цифровых вызовов как одного из наиболее успешных и действенных механизмов, способных охватить как можно больше клиентов. Следующие выводы являются наиболее важными из тех, что сделаны авторами: применение электронного маркетинга требует предоставления соответствующей цифровой среды, доступности интернета и распространения. Электронный менеджмент сделал электронный маркетинг необходимостью нашей эпохи, и успех электронного маркетинга требует опоры на тщательно изученные точные стратегии. В статье также сказано о том, что в одной и той же организации можно использовать несколько стратегий в соответствии с развитием внутренней и внешней среды организации. Успешный выбор из различных стратегий должен основываться на изучении и аналитическом исследовании различных входов и выходов информации, а также точности и фактической способности отражения целей.
СИСТЕМА МАРКЕТИНГА В ОРГАНИЗАЦИИ
Authors: Хадуева Я.А.
Published: July 2022

В статье рассматриваются сущность и основные характеристики маркетинговой деятельности предприятия, стратегическое планирование. Маркетинговая деятельность – это неотъемлемая часть функционирования компании. Однако оптовые компании, которые осуществляют свою деятельность в рамках непростой ситуации на рынке России, ведут маркетинговую политику в разных направлениях. Одни не знают даже ос-нов, способных обеспечить успешную реализацию возможностей, другие используют методы маркетинга, поэтому их деятельность даёт эффективный результат. Если говорить о маркетинге, то данные решения могут быть ориентированы на одно из следующих направлений политики: товарная, ценовая, распределительно-сбытовая, коммуникативная. В основе любого решения, принятого в сфере маркетинга, лежит политика производства товаров, а уже вокруг нее создаются задачи по рекламе и продвижению товаров от самой компании к ее потенциальному покупателю маркетинговой политики.
ЭФФЕКТИВНОСТЬ ИНВЕСТИЦИОННОЙ ПОЛИТИКИ ГОСУДАРСТВА И ФОРМИРОВАНИЕ ИНВЕСТИЦИОННОГО КЛИМАТА РЕГИОНА
Authors: Хадуева Я.А. , Арсимерзуева М.А.
Published: July 2022

Стабильное развитие региона и реализация грамотной, рациональной инвестиционной политики являются комплексным процессом, ведущим к решению вопросов общества на региональном уровне, разрешению важных социальных и экономических проблем с учетом раз-личных компонентов общественной жизни (экологии, экономики, социального обеспечения и др.). При этом происходит оптимальная реализация потенциала региона, в том числе и посредством развития инвестиционных площадок. В статье определено понятие и сущность инвестиционного климата, изучены основные факторы, влияющие на инвестиционный климат территории, рас-крыты меры государственной поддержки субъектов инвестиционной деятельности в Российской Федерации, дана общая характеристику инвестиционного климата в РФ.
ОСНОВЫ РАЗВИТИЯ СТРАТЕГИЧЕСКОГО УПРАВЛЕНИЯ СОЦИАЛЬНО-ЭКОНОМИЧЕСКИМИ ПРОЦЕССАМИ В МУНИЦИПАЛЬНОМ ОБРАЗОВАНИИ
Authors: Эльбиева Л.Р. , Иналова М.Х.
Published: July 2022

В статье проанализированы существующие теоретические и правовые модели, по которым органы местного само-управления осуществляют свои полномочия в комплексе с социально-экономическим развитием муниципальных учреждений. Сложно представить гражданское общество, в котором нет местного самоуправления. Именно в силу этого современное государство развивает свои демократические принципы, связанные с управлением. Муниципальное управление помогает реализоваться местному, и именно оно адаптирует государственные интересы к местным территориальным. Для комфортной и благоприятной жизнедеятельности гражданам нужен отлаженный межхозяйственный механизм взаимодействия. Муниципальное управление занимается решением вопросов местного назначения, которые касаются только местных жителей. Для специалистов муниципального управления важно принятие всех решений исключительно в рамках социальных и экономических целесообразностей.
IMPLEMENTASI MODEL PEMBELAJARAN INKUIRI UNTUK MENINGKATKAN HASIL BELAJAR MATEMATIKA PESERTA DIDIK KELAS X MIPA 2 SMA NEGERI 1 ASEMBAGUS
Authors: Miarsi Miarsi
Published: July 2022

Penelitian tindakan kelas ini dilaksanakan di SMA Negeri 1 Asembagus yang bertujuan untuk meningkatkan hasil belajar matematika peserta didik kelas X MIPA 2 SMA Negeri 1 Asembagus semester ganjil tahun pelajaran 2018/2019 melalui implementasi model pembelajaran inkuiri. Penelitian ini dirancang dalam dua siklus, setiap siklus dengan tahapan, perencanaan, tindakan, pengamata, penilaian dan refleksi. Subjek penelitian tindakan kelas ini adalah peserta didik kelas X MIPA 2 SMA Negeri 1 Asembagus semester ganjil tahun pelajaran 2018/2019 berjumlah tiga puluh tiga siswa dari dua belas siswa laki-laki dan dua puluh satu siswa perempuan. Hasil belajar prasiklus, pencapaian ketuntasan klasikal aspek pengetahuan 69,67% dan aspek keterampilan 60,61%.
Autobiographisches Schreiben als Vergletscherung des Ich: Adalbert Stifter Die Mappe meines Urgroßvaters1
Authors: Frost Sabine
Published: July 2022

Adalbert Stifters Die Mappe meines Urgroßvaters (1841-1867)1 verhandelt anhand der fiktiven Autobiographie des Doktor Augustinus die Frage nach der Möglichkeit, Leben in Schrift abzubilden. Dabei werden verschiedene Metaphern der Textgenese – der Kristallisationsvorgang,
der Hausbau, die Krankenakte sowie das Tagebuch – miteinander in Verbindung gesetzt. Gemein ist diesen unterschiedlichen Metaphern lediglich, dass sie die Verschriftlichung als Mittel der Überdauerung thematisieren. In ihrer Darstellung und ungewöhnlichen Verknüpfung wird
in der Mappe die traditionelle Ausdeutung dieser Metaphern allerdings aufgebrochen. Für die Umdeutung der für den Text zentralen Vereisungsmetaphorik spielt zudem der wissenschaftliche Paradigmenwechsel um 1800 eine wesentliche Rolle. Die Fluss- und Frostmetapher basiert nämlich
auf Annahmen der antiken Naturlehre, die durch naturwissenschaftliche Erkenntnisse weitgehend reformuliert werden. Wenn Stifter in der Mappe also das Metaphernfeld von Wasser und Eis heranzieht, überlagern sich dessen konventionelle und aktualisierte Bedeutungen, was zugleich die
Aufmerksamkeit auf die Wandelbarkeit texttheoretischer Bestimmungen lenkt. Denn mit den Metaphern verändern sich auch die Zuschreibungen an das darin Allegorisierte, die Schrift.
The Effectiveness of Installing Long-lasting Insecticidal Nets as Malaria Prevention Efforts: A Systematic Literature Review
Authors: Nurhayani  , Dyah Farida Inli  , Riandini Aisyah  , Rochmadina Suci Bestari
Published: July 2022

Malaria is a parasitic disease that is often the cause of death, especially in tropical and subtropical areas. One way to eradicate malaria is to break the chain of disease transmission in order to control the mosquito vector of malaria. The use of insecticide-treated mosquito nets can be used as an alternative in controlling malaria vectors for people who refuse to use the Indoor Residual Spraying (IRS) method. The review articles were obtained through a search using the Pubmed, Google Scholar, Garuda, and ScienceDirect databases. The keywords used were (LLINs OR "Long Lasting Insecticidal Nets") AND Malaria. 1843 articles were obtained, and extraction was carried out based on the restriction criteria so that 13 articles were obtained. In conclusion, the use of insecticide-treated mosquito nets LLIN is effective in killing mosquito vectors so that it has the potential to prevent malaria.
Influence of Media on Consumers’ Behavioural Intentions Towards Entomophagy in Western Kenya
Authors: Werunga Billy Juma , Ayieko Monica Awuor , Ogara Solomon
Published: July 2022

Insects are rich in protein and fat, and various insect species contain substantial amounts of vitamins and minerals. Consequently, insects can greatly contribute to food and nutrition security. Entomophagy (consumption of insects as food) has been practised in Western Kenya for many years. However, in recent times the consumption of edible insects has declined due to the notion that consuming insects is outdated and distasteful. Numerous studies have shown that media significantly affects consumers’ food choices and dietary behaviour. Furthermore, media challenges consumer subjectivities, conceptions of consumer choice, consumer insight, consumer practices, and consumer communities. Hence, the aim of this study was to examine the influence of media on consumers’ behavioural intentions towards entomophagy in Western Kenya. The conceptual model for this study was based on the theory of planned behaviour with media as the independent variable, attitude, subjective norms, and perceived behavioural control as mediators and consumers’ behavioural intentions as the dependent variable. A questionnaire survey was used to collect data (n = 324), and valid data was analysed by the mediation analysis method. The findings revealed that media directly and indirectly through attitude and perceived behavioural control influenced consumers’ behavioural intentions towards entomophagy positively. The indirect effect through subjective norms was insignificant. The total effect, total indirect effect and direct effect were significant, thus confirming the positive influence of media on consumers’ behavioural intentions towards entomophagy. Based on the findings of the study, if optimally exploited, media can considerably contribute to the enhanced consumption of insects
Hubungan Pendidikan Dan Hukum Dalam Upaya Peningkatan Kompetensi Guru
Authors: Rosmawiah Rosmawiah , Wisman Yossita , Marni Marni
Published: July 2022

Tulisan ini bertujuan untuk membahas tentang hubungan antara pendidikan dan hukum serta kedudukannya dalam masyarakat Indonesia. Situasi pendidikan di Indonesia diterapkan harus ditegakkan dengan tepat sesuai dengan peraturan dan perundangan yang berlaku. Semua guru harus memahami bahwa konsep atau metode pendidikan selalu berkembang sesuai dengan kebijakan hukum dan peraturan yang berlaku. Intinya kita harus memahami, mengamalkan dengan konteks kekinian. Demikian pula hukum harus diterapkan dalam konteks kekinian. Dalam kehidupan sehari-hari, manusia harus berjalan, tidak berhenti, berbelok ke kiri dan ke kanan, terkadang mundur, tetapi harus terus maju dalam mencapai apa yang diinginkannya dengan memperhatikan keadaan sekitar, salah satunya adalah memperhatikan hal-hal yang berkaitan. untuk pendidikan dan hukum. Baik secara epistemologis, aksiologis maupun ontologis apa yang dimaksud dengan pendidikan? Apa landasan hukum pendidikan di Indonesia? Bagaimana hubungan antara pendidikan dan hukum dalam upaya peningkatan kompetensi guru?
¿Cuáles son las debilidades y oportunidades del neuromarketing en la industria publicitaria española?
Authors: Arrufat Martín Sandro , Baños González Miguel , Baraybar Fernández Antonio
Published: July 2022

El neuromarketing ha despertado un interés manifiesto en la investigación sobre el comportamiento del consumidor como alternativa o como complemento de las técnicas tradicionales de investigación de mercados para medir la eficacia de las campañas publicitarias. Sin embargo, pese al auge en el mundo académico, el neuromarketing no ha tenido un desarrollo similar en el mundo profesional, lo que nos hace preguntarnos por los motivos de su escasa aplicación en este ámbito. Este artículo profundiza en las ventajas e inconvenientes del neuromarketing frente a las técnicas de investigación tradicionales, así como en su aplicabilidad en el ámbito profesional.
Empowerment Coffee Farmers in Kemiri Village Through Actors Theory Based on Pentahelix Model
Authors: Jamillah Kamillaeni , Pradita Yossy Eka , Setyanti Sri Wahyu Lelly Hana
Published: July 2022

The purpose of this study was to analyze the application of coffee farmer community empowerment through ACTORS theory based on the Pentahelix model as economic optimization of Kemiri Village, Panti District. Jember Regency is famous for its natural wealth, one of which is coffee plantations scattered throughout the region. Panti District is one of the coffee-producing areas and is included in the top 5 coffee producers with a potential harvest area of 149.70 with total coffee production in 2020 of 121.95 quintals (BPS Jember, 2021). One of the villages that have the potential for coffee is Kemiri Village. However, the existing potential has not been able to improve the standard of living of the community, especially coffee farmers (observation results, 2022). This problem can certainly be overcome and has relevance through ACTORS Theory and Pentahelix models which can be implemented for Kemiri Village coffee farmers. This research was conducted using a qualitative type with purposive and snowball sampling. The primary data was obtained through interviews and direct observation of the object of research. Secondary data is indirect data obtained from publications, documentation, journals. Through this research, it is hoped that researchers will be able to analyze the application of community empowerment for coffee farmers to be able to support the economy of the local community.
Vascular Complications in Diagnosed Type 2 Diabetes Mellitus
Authors: Aishwarya  , Aditya Agarwal
Published: July 2022

Background and Objectives:India is claimed to be the diabetes capital of the world. Many studies had proven that persistent hyperglycemiaand associated metabolic syndrome features like hypertension, dyslipidemia and obesity contribute to thedevelopment of vascular complications.The present study aims to study the prevalence and clinical profile of microvascular and macrovascularcomplications in newly diagnosed type 2 diabetes mellitus patients.Methods: The study is a clinical, prospective and observational study of 100 newly detected type 2 diabeticsattending medicine department outpatient/ inpatient, SGRRIMHS hospital, dehradun, form the subject for thestudy August 2018 to July 2020 (24 months) who matched the inclusion criteria.Results: In this, 62 were males and 38 were females and the mean age was 54.05±13.24 years. 44% were detectedwhen they presented with multiple complications due to diabetes. Common complications which they presentedwere coronary artery disease (15%), infection (12%), stroke (6%), ulcers (4%), neuropathy (4%) and diabeticketoacidosis (1%). The prevalence of macrovascular complications CAD, CVD and PAD was 26.0%, 8.0% and11.0% respectively and microvascular complications retinopathy, nephropathy and neuropathy was 20.0%, 34.0%and 16.0% respectively.High incidence of complications especially microvascular and CAD occur with HbA1c ofrange >6.5. The correlation coefficient of FBS and PPBS in relation to HbA1c was 0.56 and 0.57 respectively.Conclusion: Smoking, increased BMI and waist circumference is associated with increased prevalence of diabetes.There is high prevalence of coronary artery disease, retinopathy and nephropathy at diagnosis. HbA1c levelspredict the prevalence of complications.
A Study to Assess the Effectiveness of Buerger Allen Exercise on Lower Extremity Perfusion Among Diabetes Mellitus Patients Admitted in Selected Hospitals
Authors: Vikas Machhindra Miskin
Published: July 2022

Introduction: Healthy life is the valuable gift of an individual, if a person is healthy enough he is the richestperson in his own world. But there are certain disease condition which affect many people in our world, such asheart problem, neurological problem, orthopedic problem, metabolic disorder especially diabetes mellitus, amongwhich diabetes mellitus is the one of the important health concerns in today’s world. Diabetes mellitus is a globalpublic health problem; growing as an epidemic in both developed and developing countries.Objectives Of The Study:1. To assess existing lower extremity perfusion among diabetes mellitus patients.2. To evaluate the effectiveness of Buerger- Allen exercise on lower extremity perfusion among the experimentalgroup.3. To find out the association between pre-interventional scores of Buerger Allen exercise with selected demographicvariables, among diabetes mellitus patients.Methodology: In the present study Experimental one group pre-test post-test design was used to determine theeffectiveness Buerger Allen exercise on lower extremity perfusion among diabetes mellitus admitted in selectedhospitals. Samples were selected using consecutive sampling technique.Result: The subjects enrolled in the studies were 30 participation of diabetes mellitus type 2 patients. In presentstudy 30 patients with diabetes mellitus type 2 were enrolled in hospital setting.Age group: The majority of the subjects 12 (40%) belonged to the age group of 51-60.Gender: Majority of subjects were 19 (63.3%) were male and 11(36.7) minimum were female.Specific habits: 15 (50%) majority of subjects had specific habits of tobacco chewing subjects while minimum5 (16.7%) are smoking.Diet: Majority of the subjects 21(70%) belonged to the mixed diet, while minimum 9(30%) subjects belonged tovegetarian diet.Conclusion: The above interventional study was a good learning experience for, investigator. The result of thisstudy showed that, Buerger Allen exercise was effective. As per subjects response on lower extremity perfusionamong Diabetes Mellitus type 2, thus null hypothesis (H0) is rejected and alternative hypothesis (H1) is accepted.This study proved that the Buerger Allen exercise were effective and will help in the reduction of risk of lowerextremity perfusion among Diabetes Mellitus type 2 subjects.
Taxonomy of the intertidal athetine genus Eubadura stat. nov. (Coleoptera: Staphylinidae: Aleocharinae) from Japan, with descriptions of two new species
Authors: Tasaku Yuto , Maruyama Munetoshi
Published: July 2022

The genus Eubadura Sawada, 1990 stat. nov. (Athetini: Athetina) which has formerly been regarded as a subgenus of the genus Atheta Thomson, 1858, from Japan is revised. The genus Osakatheta Maruyama, Klimaszewski & Gusarov, 2008 is synonymized with Eubadura. Four species are recognized in the genus: Eubadura akiensis (Sawada, 1990), comb. nov. (Japan: Hokkaidô, Honshû, Shikoku, Kyûshû), E. yasukoae (Maruyama, Klimaszewski & Gusarov, 2008), comb. nov. (Japan: Honshû; Korea), E. onoi sp. nov., (Japan: Honshû) and E. hokkaidensis sp. nov. (Japan: Hokkaidô). Key to the species is given, and a systematic position of Eubadura is discussed.
Examination of the growth rates of environmental isolates compared with compendial strains
Authors: Sandle Tim
Published: July 2022

For some years there has been a regulatory drive for microbiology laboratories to use environmental isolates for media quality control and for the incorporation into method suitability studies. Where these organisms are included in testing regimes, do they take longer to grow? This paper assesses the growth rates of environmental isolates in comparison with compendial recommended cultures. The research presented here finds that environmental isolates do take slightly longer to grow compared with laboratory strains, yet this time difference was within the recommended incubation times of each test type. Therefore, microbiologists should generally expect slower growth but test methods may not need to be adapted to compensate.
Application of Quality by Design Approach in Development of Cefixime Trihydrate Loaded Gastro-retent
Authors: Mishra Ankit , Chaturvedi Priyanka , Paswan Suresh Kumar
Published: July 2022

Cefixime is an antibiotic that belongs to the 3rd generation cephalosporin antibacterial and acts by interrupting the cell wall synthesis of bacteria. It is a weakly acidic drug primarily absorbed through the stomach and upper intestine as a unionized drug. The drug is incompletely absorbed from GIT, leading to poor bioavailability. The current research focuses on developing gastro-retentive mucoadhesive microspheres loaded with cefixime trihydrate. The drug remains in the unionized form in acidic pH, showing enhanced absorption through the stomach. Mucoadhesive microspheres of cefixime trihydrate were prepared using HPMC K15M and Carbopol 971P as carrier polymer and mucoadhesive polymer, respectively. The formulation was prepared by using the spray drying technique.

Further, the in-vitro evaluation of the mucoadhesive property of cefixime microspheres was done on the goat stomach mucosa. The study showed a strong mucoadhesion of 82% for an extended period of gastroprotection up to 6 hours. The in-vitro drug release study of microspheres was performed using 0.1 N HCl. The prepared formulation exhibited extended release for up to 8 hours. It is concluded from the above studies that the current formulation has been elicited prolonged gastric residence time as well as extended-release and provided an opportunity for better and enhanced absorption of the drug. Thus, the formulation may be projected for better therapeutic value, probably by improving the bioavailability of the experimental drugs.
The impact of medicines shortages on pharmaceutical practice
Authors:   Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania, Focsa Alin-Viorel , Birsan Magdalena ,   Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania, Dragan Maria ,   Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania, Stan Ruxandra Teodora ,   Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Mircea Cornelia ,   Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania, Stan Catalina Daniela ,   Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania
Published: July 2022

Access to medicines is a fundamental human right and is a vital element of health care. Over the last 10 years, there has been a tendency for the global discontinuation of drug supply to become a major problem, with an increasing exacerbation of this phenomenon in the European Union, with a potential negative impact on patient health care due to multiple causes (manufacturing problems, drug pricing policy, parallel export etc.). National Agency for Medicines and Medical Devices of Romania (NAMMDR) argues, in full agreement with European Medicines Agency, that in this situation effective collaboration between the various stakeholders and regulators is required, and also a good communication between manufacturers, distributors and authorities. It is a point of view that NAMMDR supported in the working meetings with the representatives of the marketing authorization holders/ manufacturers, wholesale distribution, patient associations. According to pharmacists, situations have been reported in which patients tend to stock up on medicines, and this puts additional pressure on existing stocks. In this work, we intended to draw attention to the medicine shortages issue which has a huge impact on national health systems, on patients′ safety, on public health and healthcare professionals.
Psoriasis, inflammatory bowel disease, and uveitis as paradoxical adverse effects induced by TNF inhibitors in patients with immune-inflammatory rheumatic conditions
Authors:   Department of Rheumatology and Rehabilitation, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania, Margineanu Damiana , Burlui Alexandra ,   Department of Rheumatology and Rehabilitation, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania,   Clinical Rehabilitation Hospital, Iasi, Romania, Cardoneanu Anca ,   Department of Rheumatology and Rehabilitation, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania,   Clinical Rehabilitation Hospital, Iasi, Romania, Macovei Luana Andreea ,   Department of Rheumatology and Rehabilitation, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania,   Clinical Rehabilitation Hospital, Iasi, Romania, Bratoiu Ioana ,   Department of Rheumatology and Rehabilitation, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania, Richter Patricia ,   Department of Rheumatology and Rehabilitation, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania, Rezus Elena ,   Department of Rheumatology and Rehabilitation, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania,   Clinical Rehabilitation Hospital, Iasi, Romania
Published: July 2022

Despite their known benefits, tumor necrosis factor alpha inhibitors (TNFi) may cause certain unexpected side effects, such as the aggravation of pre-existing autoimmune conditions or inducing the onset of new inflammatory conditions, these reactions being called “paradoxical adverse effects’’ (PAEs). The spectrum of TNFi-induced PAEs is vast and may include dermatological disease (frequently - psoriasiform skin reactions), gastroenterological disease (inflammatory bowel disease), ophthalmological disease (uveitis) and other autoimmune conditions (lupus-like reactions, vasculitis). PAEs are characterized by complex physio-pathological mechanisms which remain a matter of further research and may significantly impact the patients’ evolution and quality of life. Importantly, a large number of patients require the cessation of TNFi treatment, as well as other types of therapeutic interventions. The present review aimed to analyze recent findings regarding certain paradoxical adverse effects (psoriasis, inflammatory bowel disease, and uveitis) in patients with RA, ankylosing spondylitis (AS), and PsA treated with TNFi.
Fetal cardiac fibroelastosis - a consequence of anti-Ro maternal transfer during pregnancy. Case report and review of the literature
Authors:   Filantropia Clinical Hospital, Bucharest, Romania, Duminica Turcu Ana , Gica Nicolae ,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania,   Filantropia Clinical Hospital, Bucharest, Romania, Botezatu Radu ,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania,   Filantropia Clinical Hospital, Bucharest, Romania, Peltecu Gheorghe ,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania,   Filantropia Clinical Hospital, Bucharest, Romania, Panaitescu Anca Maria ,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania,   Filantropia Clinical Hospital, Bucharest, Romania
Published: July 2022

With scarcely any reports published on the association of fetal endocardial fibroelastosis and Ro antibodies maternal transfer during pregnancy, this subject continues to raise concern among health care providers around the world, especially when neonatal lupus syndrome is taken into consideration as the main diagnosis. Fetuses with congenital atrioventricular block have a risk of intrauterine fetal demise and the concern comes from a variety of factors that show significant association between the presence of maternal antibodies to SS-A/Ro during pregnancy and their children serum level of these antibodies. Nevertheless, fetal endocardial fibroelastosis plays an important role in altering ventricular diastolic function and ventricular development in children and neonates. Methods. Medical literature was searched on PubMed and Medline using key words such as fetal endocardial fibroelastosis, anti-Ro antibodies in pregnancy and neonatal lupus syndrome and over 200 articles were taken into consideration, with 17 of them included in the final review. The clinical case included in this paper was referred to the Department of Maternal Fetal Medicine, Filantropia Clinical Hospital in Bucharest, during the second pregnancy after a first pregnancy that resulted in stillbirth with congenital heart block and fibroelastosis as a result of the maternal diagnosis of Sjogren’s syndrome with transplacental transfer of SS-A/Ro antibodies.
Rheumatoid arthritis overlapping systemic sclerosis with interstitial lung disease
Authors:   “Dr. Ion Stoia” Clinical Center of Rheumatic Diseases, Bucharest, Romania, Ionescu Catalina-Elena ,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Mogosan Corina ,   “Dr. Ion Stoia” Clinical Center of Rheumatic Diseases, Bucharest, Romania,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Enache Luminita ,   “Dr. Ion Stoia” Clinical Center of Rheumatic Diseases, Bucharest, Romania,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Popescu Claudiu ,   “Dr. Ion Stoia” Clinical Center of Rheumatic Diseases, Bucharest, Romania,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Dumitrescu Bianca ,   “Dr. Ion Stoia” Clinical Center of Rheumatic Diseases, Bucharest, Romania,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Dinache Georgiana ,   “Dr. Ion Stoia” Clinical Center of Rheumatic Diseases, Bucharest, Romania,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Codreanu Catalin ,   “Dr. Ion Stoia” Clinical Center of Rheumatic Diseases, Bucharest, Romania,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania
Published: July 2022

Lung disease is the second most frequent extra articular manifestation in rheumatoid arthritis (RA) patients. It can be present in up to 80% RA cases and represents a major cause of morbidity and mortality. One of the most common types of lung involvement in RA patients is the interstitial lung disease (ILD). Computed tomography studies show evidence of ILD in a large proportion of patients with RA (over 50% in some studies) and it can be clinically symptomatic in 5% of cases. The CT aspect classifies four forms of ILD, listed in order of frequency: usual interstitial pneumonia (UIP) - the most common form, non-specific interstitial pneumonia (NSIP), organizing pneumonia (OP) and diffuse alveolar damage (DAD) which is the least common form. We present a long-standing case of rheumatoid arthritis overlapping systemic sclerosis with interstitial lung disease.
The use of metal alloys in the manufacture of fixed prosthetic restorations
Authors:   Doctoral School ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Ciochinda Gabriel , Augustin Mihai ,   Department of Oral Implantology, ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Tanase Gabriela ,   Department of Oral Implantology, ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: July 2022

The techniques and classical methods used to make fixed prosthetic restorations may involve recycled metal alloys from previous castings. The article presents an assessment of the procedures that dental technicians apply, the principles and criteria that are at the base of their choices and decisions when they use metal alloys in fixed prosthetic restorations. Objective. The article aims at the identification of the practices used by dental technicians in Romania when manufacturing non-noble metal alloys prosthetic suprastructures. Material and method. The data collection methodology is an attribute of both quantitative and qualitative research. Results. Over 50% of the dental laboratories are using classical methods of processing metal alloys, 82% of dental technicians use non-noble alloys (Cr-Ni, Cr-Co). 60.7% apply the recycling technique by reusing alloys and 46.4% of them are reusing the materials. Defining factors for choosing recycling process are determined on "personal appreciation based on experience in the field" and "financial-economic" criteria. Discussions. Scientific studies investigating the negative effects of recycling processes used for fixed prosthetic suprastructures emphasize on microstructural and chemical changes, consequences on the mechanical strength of the materials. They underline the strength in acidic environment, significant long-term toxic contribution in relation to the acidic environment of the oral cavity. Conclusions. The predominant use of classical laboratory methods favours the over-reuse of alloys left overs from previous melts as well as materials. The effects of these techniques are drastic and the cautious use is fundamental.
Photometry on Structured Backgrounds: Local Pixel-wise Infilling by Regression
Authors: Saydjari Andrew K. , Finkbeiner Douglas P.
Published: July 2022

Photometric pipelines struggle to estimate both the flux and flux uncertainty for stars in the presence of structured backgrounds such as filaments or clouds. However, it is exactly stars in these complex regions that are critical to understanding star formation and the structure of the interstellar medium. We develop a method, similar to Gaussian process regression, which we term local pixel-wise infilling (LPI). Using a local covariance estimate, we predict the background behind each star and the uncertainty of that prediction in order to improve estimates of flux and flux uncertainty. We show the validity of our model on synthetic data and real dust fields. We further demonstrate that the method is stable even in the crowded field limit. While we focus on optical-IR photometry, this method is not restricted to those wavelengths. We apply this technique to the 34 billion detections in the second data release of the Dark Energy Camera Plane Survey. In addition to removing many >3σ outliers and improving uncertainty estimates by a factor of ∼2–3 on nebulous fields, we also show that our method is well behaved on uncrowded fields. The entirely post-processing nature of our implementation of LPI photometry allows it to easily improve the flux and flux uncertainty estimates of past as well as future surveys.
An Expanding Shell of Neutral Hydrogen Associated with SN 1006: Hints for the Single-degenerate Origin and Faint Hadronic Gamma-Rays
Authors: Sano H. , Yamaguchi H. , Aruga M. , Fukui Y. , Tachihara K. , Filipović M. D. , Rowell G.
Published: July 2022

We report new H i observations of the Type Ia supernova remnant (SNR) SN 1006 using the Australia Telescope Compact Array with an angular resolution of

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5
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(∼2 pc at the assumed SNR distance of 2.2 kpc). We find an expanding gas motion in position–velocity diagrams of H i with an expansion velocity of ∼4 km s−1 and a mass of ∼1000 M
⊙. The spatial extent of the expanding shell is roughly the same as that of SN 1006. We here propose a hypothesis that SN 1006 exploded inside the wind-blown bubble formed by accretion winds from the progenitor system consisting of a white dwarf and a companion star, and then the forward shock has already reached the wind wall. This scenario is consistent with the single-degenerate model. We also derived the total energy of cosmic-ray protons W
p to be only ∼1.2–2.0 × 1047 erg by adopting the averaged interstellar proton density of ∼25 cm−3. The small value is compatible with the relation between the age and W
p of other gamma-ray SNRs with ages below ∼6 kyr. The W
p value in SN 1006 will possibly increase up to several 1049 erg in the next ∼5 kyr via the cosmic-ray diffusion into the H i wind shell.
Serendipitous Discovery of Three Millisecond Pulsars with the GMRT in Fermi-directed Survey and Follow-up Radio Timing
Authors: Bhattacharyya B. , Roy J. , Freire P. C. C. , Ray P. S. , Johnson T. J. , Gupta Y. , Bhattacharya D. , Kaninghat A. , Ferrara E. C. , Michelson P. F.
Published: July 2022

We report the discovery of three millisecond pulsars (MSPs): PSRs J1120−3618, J1646−2142, and J1828+0625 with the Giant Metrewave Radio Telescope (GMRT) at a frequency of 322 MHz using a 32 MHz observing bandwidth. These sources were discovered serendipitously while conducting the deep observations to search for millisecond radio pulsations in the directions of unidentified Fermi Large Area Telescope (LAT) γ-ray sources. We also present phase coherent timing models for these MSPs using ∼5 yr of observations with the GMRT. PSR J1120−3618 has a 5.5 ms spin period and is in a binary system with an orbital period of 5.6 days and minimum companion mass of 0.18 M
⊙, PSR J1646−2142 is an isolated object with a spin period of 5.8 ms, and PSR J1828+0625 has a spin period of 3.6 ms and is in a binary system with an orbital period of 77.9 days and minimum companion mass of 0.27 M
⊙. The two binaries have very low orbital eccentricities, in agreement with expectations for MSP-helium white dwarf systems. Using the GMRT 607 MHz receivers having a 32 MHz bandwidth, we have also detected PSR J1646−2142 and PSR J1828+0625, but not PSR J1120−3618. PSR J1646−2142 has a wide profile, with significant evolution between 322 and 607 MHz, whereas PSR J1120−3618 exhibits a single peaked profile at 322 MHz and PSR J1828+0625 exhibits a single peaked profile at both the observing frequencies. These MSPs do not have γ-ray counterparts, indicating that these are not associated with the target Fermi LAT pointing emphasizing the significance of deep blind searches for MSPs.
Wandering Black Hole Candidates in Dwarf Galaxies at VLBI Resolution
Authors: Sargent Andrew J. , Johnson Megan C. , Reines Amy E. , Secrest Nathan J. , van der Horst Alexander J. , Cigan Phil J. , Darling Jeremy , Greene Jenny E.
Published: July 2022

Thirteen dwarf galaxies have recently been found to host radio-selected accreting massive black hole (MBH) candidates, some of which are “wandering” in the outskirts of their hosts. We present 9 GHz Very Long Baseline Array (VLBA) observations of these sources at milliarcsecond resolution. Our observations have beam solid angles ∼104 times smaller than the previous Very Large Array (VLA) observations at 9 GHz, with comparable point-source sensitivities. We detect milliarcsecond-scale radio sources at the positions of the four VLA sources most distant from the photocenters of their associated dwarf galaxies. These sources have brightness temperatures of >106 K, consistent with active galactic nuclei (AGNs), but the significance of their preferential location at large distances (p-value = 0.0014) favors a background AGN interpretation. The VLBA nondetections toward the other nine galaxies indicate that the VLA sources are resolved out on scales of tens of milliarcseconds, requiring extended radio emission and lower brightness temperatures consistent with either star formation or radio lobes associated with AGN activity. We explore the star formation explanation by calculating the expected radio emission for these nine VLBA nondetections, finding that about five have VLA luminosities that are inconsistent with this scenario. Of the remaining four, two are associated with spectroscopically confirmed AGNs that are consistent with being located at their galaxy photocenters. There are therefore between five and seven wandering MBH candidates out of the 13 galaxies we observed, although we cannot rule out background AGNs for five of them with the data in hand.
Mathematical Model of a Gas-Operated Machine Gun
Authors: V. D. Tien , Macko Martin , Procházka Stanislav , V. V. Bien
Published: July 2022

The article describes a thermodynamic mathematical model of internal ballistics in the barrel and in the gas cylinder of a gas-operated gun. In addition, this thermodynamic mathematical model deals with the mass flow of gas through the ring around the piston into the atmosphere. The thermodynamic mathematical model and the solution algorithm are validated and verified experimentally on the example of a 7.62 mm UK-59 machine gun and 7.62 x 54 R ammunition. The conclusions of this paper are applicable to the calculation and design of the machine gun gas propulsion structure for similar weapons with dust gas extraction.
Classification of Combat Wheeled Vehicles Using Cluster Analysis Methods
Authors: Golub Victor , Kurban Volodymyr , Sedov Sviatoslav , Golub Gennadii
Published: July 2022

The functionality and purpose of combat wheeled vehicles (CWV) models are determined by both the requirements of the armed forces and the financial and technical capabilities of military equipment manufacturers. This leads to a discrepancy between the technical characteristics of the CWV model and its combat purpose. For the classification of CWV, an approach is proposed that consists of using generalized indicators that characterize the combat properties of CWV models, which allows establishing a correspondence between the technical characteristics of CWV models and their functional purpose, provides an opportunity to develop rational protection options and to justify specific technical solutions to increase the level of survivability of CWV models within groups.
Assessing Availability of GNSS-GBAS Landing Systems in GAST-D/F Performance
Authors: Alhosban Ahmad
Published: July 2022

The Ground-Based Augmentation System (GBAS) has been recently approved as CAT II performance (GBAS Approach Type D (GAST-D)) for the precision approach operations, and by using the GPS signals only. But the requirements of CAT III performance (GAST-F) are tended to be approved using dual Constellation by adding the European Galileo system. In this research, the availability of CAT III was assessed using Galileo system. A simulation tool was used to estimate which level of integrity and accuracy is needed for CAT II and CAT III performances, considering the new innovated Binary Offset Carrier (BOC) modulation and the increased power of +6 dB in Galileo signals. The results showed a promising performance of Galileo over Europe space.