bluuebunny/crossref_metadata_2025 huggingface dataset:
Knowledge Management in Sustainable Competitive Destinations (SCD) of National Cultural Tourism Event Bakar Tongkang Bagansiapiapi
Authors: Ginting Yanti Mayasari , Sitompul Silvia Sari , Siregar Helly Aroza , Nainggolan Raya Desmawanto , Yusriadi Yusriadi
Published: December 2023

Purpose: This study aims to discuss the concept of sustainable competitive destination (SCD) in cultural tourism based on knowledge management to ensure that the collaboration in a balanced way contributes to the economy through increasing tourist visits, providing benefits to local communities, and preserving existing culture. Methodology: This article conducts an in-depth literature review related to the development of cultural tourism through ecosystem synergy and applies Nonaka’s knowledge conversion framework in explaining the role of knowledge management in the knowledge collaboration of cultural tourism ecosystems to create SCDs. Finding: Research activities by academics have not been followed up in real terms. Academics are less motivated to synergize the ecosystem. The participation of the people of Rokan Hilir Regency remains lacking. Originality: This paper discusses how to apply knowledge management in cultural tourism, and ecosystem synergies in creating an SCD for the national cultural event Bakar Tongkang Bagansiapiapi. Research implications: Implementation of knowledge management concepts in the cultural tourism ecosystem is a necessity. Practical implications: The synergy of Penta Helix is built through an understanding of the capacity of stakeholders to ensure that it can be a guide for each in creating the SCD for the Bakar Tongkang cultural event in Bagansiapiapi. Social implications: Tourism management and marketing strategies have reached local and foreign tourists who are related to the Tionghoa descendants of Bagansiapiapi.
Unnaming and mis/naming as a thematic strategy in Bulawayo's We need new names and Tagwira's The Uncertainty of Hope
Authors: Mavengano Esther
Published: December 2023

Previously, names in literary contexts were generally treated as peripheral lexical items or mere identity tags for the personages and geo-spaces in texts. Yet, recently, the subject has become a polemical one, accorded much scholarly attention as evident in a remarkable upsurge of fascinating examination of literary names and a profound increase in academic conversations about naming practices in fictive landscapes. What is more interesting is the argument that names in fictive discourse are an inherent and indispensable part of the textual composition which contributes to the overall semantics of the text. Drawing from this realisation, the study further explores the premise that naming is not arbitrary but rather, a salient and (sub) conscious artistic technique that provides significant semiotic avenues for the articulation and signification of nuanced and dynamic meanings. This study interrogates the stylistic, thematic functions and semantic possibilities of some toponyms, anthroponyms and charactonyms in selected contemporary Zimbabwean novels from an onomastic perspective. The study proposes that onomastics could offer critical and refreshing interpretive insights aimed to provide rich avenues of reading and decoding thematic preoccupations in the chosen novels.
Swearing and cursing. Contexts and practices in a critical linguistic perspective. Edited by Nico Nassenstein and Anne Storch. Berlin: de Gruyter Mouton 2021.
Authors: Arich-Gerz Bruno
Published: December 2023

Swearing and cursing are little-recognised and cross-culturally ostracised, but subliminally particularly effective expressions in any language. As the papers in Swearing and Cursing, an anthology edited by Nico Nassenstein and Anne Storch as proceedings of a 2015 convention in Cologne, demonstrate, the two terms imply more than a speech act, though. Verbal snotting, the use of taboo words and its emotion make use of materialities and modalities whose study usefully complements the existing book-length analyses by Magnus Ljung (Swearing: A cross-cultural linguistic Study, 2010) or Timothy Jay (Why we Curse, 2000). It is Jay whom the editors present as the opener to their collection of sixteen articles, giving him room for consideration of the state of arts in Swearingistics and Cursingology.
Remembering a Traumatic Past
Authors: Chikwangura-Gwatirisa Yemurai
Published: December 2023

This article analyses the narratives of Gukurahundi , how they are perceived as forms of collective memory culture, how they help to explain personal experiences shared by victims of the 1980s genocide in Zimbabwe, and how these experiences become memory. The Gukurahundi genocide shows that not only do individuals remember, but that remembering can be a collective endeavour. While individual memory is usually bound to the short time span of a human life and disappears with the death of a particular individual, intergenerational and collective cultural memory, on the other hand, is of longer term and is supported by institutions, monuments and rites. This article acknowledges different types of memories and dwells not only on the collective and cultural memory that honours and praises the heroic deeds of Zimbabwe, but also on the painful collective memories of perpetration or guilt. It highlights the importance of documenting events that happened during Gukurahundi. In Zimbabwe, there is state owned documentation and other documentation, which, in this paper, would be referred to as counter archives. The types of documentation can be regarded as a way that Zimbabweans, especially the Ndebele ethnic group, remember or memorialise the past.
Magnetocaloric materials for hydrogen liquefaction
Authors: Romero-Muñiz Carlos , Law Jia Yan , Revuelta-Losada Jorge , Moreno-Ramírez Luis M. , Franco Victorino
Published: December 2023

The expected energy transition to hydrogen gas as a greener energy vector has revived the interest in magnetic refrigeration at the cryogenic range, specifically between 20 and 80 K, with the vision to develop a new generation of hydrogen gas liquefiers. From the materials science point of view, the search for magnetocaloric materials containing mainly non-critical elements with a significant response in that temperature range, together with good cyclability and stability, is a challenging task. Given the increasing interest of the research community on this topic, we aim to establish a comprehensive catalog of the magnetocaloric compounds characterized so far, to be used as a starting point for further research. For this purpose, a systematic outlook of the state of the art is presented here, with the analysis and classification of more than 400 cryogenic magnetocaloric materials, divided into five large families according to their physicochemical properties. Moreover, we provide detailed information about their magnetocaloric properties, magnetic behavior, and transition characteristics together with criticality, which will facilitate the future search for optimal compounds.
O ‘efeito estufa’ numa perspectiva histórica: Jean Baptiste Joseph Fourier e o problema da temperatura terrestre
Authors: Junges Alexandre Luis
Published: December 2023

O nome do cientista francês Jean Baptiste Joseph Fourier é frequentemente lembrado como sendo o primeiro a propor uma teoria do efeito estufa. A partir de trabalhos de historiadores da ciência, e com base na análise dos textos de Fourier, suas contribuições ao problema da temperatura terrestre são discutidas. Argumenta-se que Fourier não desenvolveu uma teoria do efeito estufa. Porém, muitos dos insights e conceitos que ele introduziu, como o conceito de temperatura planetária e balanço de energia planetário, abriram caminho para desenvolvimentos subsequentes sobre o problema da temperatura terrestre. Com base nesse relato histórico, almeja-se fomentar a discussão do efeito estufa em uma aula de ciências, em especial da física. Tal discussão pode contribuir para elucidar questões conceituais, bem como fornecer uma perspectiva histórica sobre a questão atual das emissões de gases de efeito estufa e suas consequências para o aquecimento global.
SISTEM PENDUKUNG KEPUTUSAN MENGGUNAKAN METODE PROFILE MATCHING DALAM PENENTUAN SALES TERBAIK DI Murni Gold & Jewellery
Authors: Ilham Wanda , Lelisa Army Widya
Published: December 2023

Murni Gold & Jewellery adalah bidang usaha yang bergerak dalam penjualan perhiasan emas dan perhiasan Murni Gold & Jewellery adalah satu-satu nya pelopor pertama yang menjual emas dan perhiasan dengan kualitas terbaik di wilayah Kota Padang tidak hanya menjual emas tetapi juga menjual perhiasan akan tetapi lebih terfokus dalam menjual emas kebutuhan masyarakat terhadap emas sangatlah  diminati. Baik perempuan maupun laki-laki untuk menunjang penampilan mereka dalam beraktifitas harga yang ditawarkan cukup terjangkau bukan hanya untuk kalangan atas tapi bisa juga untuk kalangan menengah.

Dengan adanya sistem pendukung keputusan, hasil penentuan sales terbaik lebih tepat dan keputusan yang diambil dapat lebih dari satu kriteria tidak hanya dari penjualan tertinggi saja. Penerapan metode Profile Matching dapat membantu dalam pengambilan keputusan penentuan sales terbaik. Aplikasi yang dirancang  dapat lebih efektif dalam penentuan sales terbaik di Ens Collections. Sistem ini berbasis web yang dibuat dengan memanfaatkan seperangkat komputer yaitu laptop dan menggunakan bahasa pemrograman PHP dan menggunakan database MySQL.

Kata Kunci: Sistem Pendukung Keputusan, Sales Terbaik, Profile Matching, Web, Emas.
Ekonominių ir religinių veiksnių įtaka postmaterialistinių vertybių sklaidai pirmojoje pokomunistinėje kartoje: lyginamoji 24 šalių analizė
Authors: Daukšaitė Laura
Published: December 2023

Šiame straipsnyje pirmosios pokomunistinės kartos (gim. 1991–2000) vertybių analizei 24-iose pokomunistinėse šalyse pasitelkiama Ronaldo Ingleharto materialistinių-postmaterialistinių vertybių kaitos teorija. 1990–1993 m., 1999–2004 m., 2008– 2014 m. ir 2017–2022 m. bangų Pasaulio ir Europos vertybių tyrimų duomenų analizė leidžia daryti išvadas, kad daugumoje pokomunistinių šalių postmaterialistinės vertybės pirmojoje pokomunistinėje kartoje, palyginti su vyresnėmis kartomis, sustiprėjo. Tokia tendencija ypač ryški ekonomiškai stipriose pokomunistinėse šalyse, tačiau matoma ir ekonomiškai nepasiturinčiose. Tik šešiose šalyse fiksuotas statistiškai reikšmingas ryšys tarp religijos svarbos žmogaus gyvenime ir materialistinių-postmaterialistinių vertybių pirmojoje pokomunistinėje kartoje. Tyrimas taip pat atskleidė, kad šalyse, kuriose dominuoja Romos katalikų tikėjimas, postmaterialistinės vertybės yra labiau paplitusios nei stačiatikių ortodoksų ir islamo dominuojamose šalyse pirmojoje pokomunistinėje kartoje.
Three-dimensional Non-linear Finite Element Analysis of Impact Response and Damage in Laminated Composite Shells
Authors: Kumar Surendra
Published: December 2023

The impact response and the impact-induced damage in curved composite laminates subjected to transverse impact by a metallic impactor are studied using three-dimensional non-linear transient dynamic finite element formulation. A layered version of isoparametric eight-noded hexahedral element with incompatible modes is developed which incorporates geometrical non-linearity based on total Langragian approach. The non-linearity of both strain displacement relation and contact loading are simultaneously solved using Newton-Raphson incrementaliterative method. Impact-induced damages (matrix cracking and delamination) are predicted using appropriate three-dimensional stress-based failure criteria. Some example problems of graphite/epoxy laminated cylindrical shells with variation of important parameters such as impactor velocity, shell curvature, laminate dimension and fibre orientation of plies are solved and the influence of geometrical non-linear effect on both impact response and resulting damages is demonstrated.
Simple Mathematical Models for the Dynamics Of Spacecraft With Deployed Solar Panels
Authors: Joseph Thomas K. , Renji K. , Venkatraman Kartik
Published: December 2023

Most present day spacecrafts have large interconnected deployed solar panels having very low natural frequencies. The control torque applied to maneuver the spacecraft sets up transient oscillations in the spacecraft. The present work studies the nature of these interactions. The spacecraft in orbit can be modeled as a free rigid mass with flexible elements attached to it. It is shown that the oscillations of the spacecraft body are characterized by the dynamic characteristics of the flexible panel even if the mass and mass moment of inertia of the body is signifcantly higher than that of the flexible panels. A simple model consisting of an Euler-Bernoulli beam attached to a mass can represents such a system. The infuence of various parameters of the Euler-Bernoulli beam and the rigid element on the disturbances caused in the rigid element are investigated. The characteristics are determined for a step and also for a torque input. The responses are obtained in terms of nondimensionalised quantities. It is demonstrated that using the simple model developed the responses of spacecraft body can be easily obtained.
Aerodynamic Characteristics of Flow Past Naca 0008 Airfoil at Very Low Reynolds Numbers
Authors: Pranesh C. , Sivapragasam M. , Deshpande M. D.
Published: December 2023

The flow around NACA 0008 airfoil was investigated computationally at two very low values of Reynolds numbers 2000 and 6000 and for various angles of attack 0 to 8°. The flow being laminar it was seen to separate at very small angles of attack. Due to large viscous effects the pressure recovery at the trailing edge is poorer as compared to the high Reynolds number case leading to lower values of lift coefficient Cl, higher values of drag coefficient Cd, and lower values of (Cl/Cd). The wake flow exhibits similarity behaviour similar to that in high Reynolds number flat-plate wake. The quantitative validity of the boundary layer equations in a limited range of parameters is ascertained.
Neural Partial Differentiation for Parameter Estimation of Flexible Aircraft Dynamics
Authors: Kuttieri Rajesh Ayilliath , Sinha Manoranjan
Published: December 2023

Although the parameter estimation methodologies had been successfully applied for the rigid aircraft dynamics, the aircraft with high degree of flexibility poses challenges to determine the appropriate aeroelastic models for inclusion in the parameter estimation algorithms. Application of the neural networks for the aerodynamic modeling and parameter estimation of an aeroelastic aircraft (or flexible aircraft) is addressed in this paper. A neural network with the scaled conjugate gradient learning algorithm is used for modeling lift and pitching moment coefficients. The partial differentiation of the neural network output is carried out for the estimation of equivalent parameters of an aeroelastic aircraft. It is demonstrated that a reasonable model and estimates of the equivalent parameters for the aeroelastic aircraft are possible with the neural partial differential method by using the measured motion and control variables, without any need for postulating the coupled equations of motion or initialization of the parameters to be estimated. The proposed approach reduces the large number of parameters for aeroelastic aircraft dynamics into fewer equivalent parameters, and this methodology does not require the measurements of the elastic deflections or their derivatives. The neural partial differential method is applied to the simulated flight data of an aeroelastic aircraft for the longitudinal dynamics. The performance of the neural partial differential approach is compared with the estimates obtained from the other methods like classical estimation methods, analytical computation, and values given in the literature for rigid body modeling. The performance is also validated by comparing the measured lift force and pitching moment coefficients with the neural predicted and neural reconstructed coefficients using the estimates obtained through the neural partial differential approach.
Applicability of Clohessy-wiltshire Model For Optimal Low-thrust Rendezvous
Authors: Kumar Yajur
Published: December 2023

This paper investigates the applicability of the continuous thrust Clohessy-Wiltshire model for the optimal low-thrust rendezvous in the orbit. While simplifying the non-linear equations of relative orbital motion, certain assumptions were taken in account by Clohessy and Wiltshire to linearize the system of equations. When the same model is used for optimization of the trajectory of a relative transfer in the orbit using low-thrust, because of the assumptions in the dynamic model there are errors in the result which in turn depends upon the initial conditions for the optimal control problem. A study has been done to investigate the possible trend of error in the control input by varying the initial conditions for the relative transfer and comparing the results with those obtained using non-linear equations. Further, the trend of error in control input has also been studied by increasing the altitude of the target spacecraft orbit. Optimization of the relative motion trajectory has been performed to account for minimum propellant expenditure.
A Boundary-Vorticity Perspective on Lift Enhancement at Ultra-Low Reynolds Numbers
Authors: Rashmi N. , Sivapragasam M.
Published: December 2023

The ultra-low Reynolds number flow over airfoils is considered from the perspective of boundary vorticity dynamics in this paper. The dynamic balance between the streamwise pressure gradient and vorticity creation rate at the wall is highlighted by the boundary vorticity flux. It is a localized feature with a high peak generally indicating impending boundary layer separation. Two interesting features of ultra-low Reynolds number flows are considered. Firstly, the higher values of lift coefficient with decreasing Reynolds number is seen to be due to delayed boundary layer separation. The peak in boundary vorticity flux clearly predicts the separation event. Secondly, the lift enhancement achieved by certain optimal airfoils due to a vortex trapped in the airfoil cavity is considered. An interesting double-peak in boundary vorticity flux seen for the optimal airfoil enhances the lift. An alternative interpretation of the lift enhancement is also provided by examining the Lamb vector-field.
Rôle modérateur du format de présentation de dilemmes de confidentialité sur la relation entre l’utilitarisme et la propension à la levée de la confidentialité
Authors: Chailler Guillaume , Cantinotti Michael , Trémolière Bastien
Published: December 2023

Bien que l’étude du jugement moral ait gagné en popularité ces dernières années dans le domaine de la psychologie, peu de recherches se sont intéressées aux dilemmes de confidentialité en contexte de jugement moral. Or, les personnes cliniciennes font régulièrement face à de tels dilemmes qui surviennent souvent dans des contextes chargés émotionnellement. Cette étude évalue le rôle des émotions dans les réponses à ces dilemmes de confidentialité. En tout, 186 participants étudiant en psychologie dans différentes universités du Québec ont été assignés aléatoirement à l’un des trois groupes d’un devis expérimental (modalité audio dramatique, modalité audio neutre, modalité texte) et ont répondu à des dilemmes de confidentialité en choisissant entre la protection ou la levée de la confidentialité. Le positionnement des participants sur un continuum allant du déontologisme à l’utilitarisme, grâce à la réponse à des dilemmes sacrificiels, a également été pris en considération. Le modèle de régression linéaire multiple hiérarchique utilisé indique un apport significatif provenant des réponses aux dilemmes sacrificiels, de l’intensité émotionnelle perçue des dilemmes de confidentialité et de la formation obtenue dans le domaine de l’éthique et de la déontologie. L’analyse révèle en outre l’effet modérateur de l’exposition à la condition expérimentale sur la relation entre la tendance à l’utilitarisme et la propension à la levée de la confidentialité dans une relation psychothérapeutique. Ces résultats ont des implications pratiques concernant le cursus en psychologie, où des mises en situation avec une validité écologique pourraient bonifier la formation en éthique.
Ethics of Medical Assistance in Dying for Non-Terminal Illness: A Comparison of Mental and Physical Illness in Canada and Europe
Authors: Birkness Katharine , Rudnick Abraham
Published: December 2023

Medical assistance in dying (MAiD) is scheduled to be legalized in Canada as of March 2024 for individuals with mental disorder/illness as their sole underlying medical condition (MAiD MD-SUMC). As guidelines are being developed for the safe and consistent provision of MAiD MD-SUMC, sufficient consideration must be given to the interpretation of ambiguous terminology in current legislation, and to ensuring sound use of acceptable ethics principles in these interpretations.
Reflecting and Regretting
Authors: Avny Ohad
Published: December 2023

This is the story of an elderly woman who suffers from dementia and has endured a lifetime of abuse from her husband. As the tale unfolds, we learn about this old woman’s tragic history, and of the attempts her doctor has made over the years to help her. The ethical issues the doctor struggles with, his emotions, as well as the strategic dilemmas he is forced to confront as he plans and manages the treatment and care of the husband and the wife create an unsettling backdrop to a story of patient and doctor behaviour. Ethical emotional and professional dilemmas when treating an abusive husband and his wife are discussed in detail.
Features of Portuguese colonial architecture in South Asia in the period from XVI to XVIII centuries.
Authors: Chen' Ke
Published: December 2023

In this article, the author analyzes the Portuguese colonial architecture in the countries of South Asia in the period from the XVI to XVIII centuries. The author examines the military, civil and religious architecture built by the Portuguese during their presence in the South Asian colonies. Special attention is paid to the Portuguese colonial architecture of India (especially Goa) and Macau. Buildings in Singapore, Thailand, Malaysia and other former Portuguese colonies in South Asia are also considered. The author studies the process of formation and features of a special Portuguese colonial style in military (fortification), civil and religious (cult) architecture. The features in the design, decoration, as well as building materials of buildings are revealed. The novelty of the study lies in the fact that for the first time the samples of Portuguese colonial architecture in South Asia and their architectural features were comprehensively considered. The main conclusions of this study are the following. Firstly, on the one hand, the European architectural tradition has enriched the culture of the South Asian region. At the same time, different types of buildings show different degrees of influence. Secondly, on the other hand, Portuguese colonial architecture in South Asia itself has undergone significant changes under the influence of local cultural and climatic factors. Many of the changes made to classical European building designs were dictated by the weather and climatic features of the area. The choice of material was dictated by climatic and geological features. The culture of local civilizations also influenced the decoration and decoration of Portuguese buildings.
Binding to nucleosome poises human SIRT6 for histone H3 deacetylation
Authors: Smirnova Ekaterina , Bignon Emmanuelle , Schultz Patrick , Papai Gabor , Ben-Shem Adam
Published: December 2023

Sirtuin 6 (SIRT6) is an NAD
+
dependent histone H3 deacetylase that is prominently found associated with chromatin, attenuates transcriptionally active promoters and regulates DNA repair, metabolic homeostasis and lifespan. Unlike other sirtuins, it has low affinity to free histone tails but demonstrates strong binding to nucleosomes. It is poorly understood how SIRT6 docking on nucleosomes stimulates its histone deacetylation activity. Here we present the structure of human SIRT6 bound to a nucleosome determined by cryogenic electron microscopy. The zinc finger domain of SIRT6 associates tightly with the acidic patch of the nucleosome through multiple arginine anchors. The Rossmann fold domain binds to the terminus of the looser DNA half of the nucleosome, detaching two turns of the DNA from the histone octamer and placing the NAD
+
binding pocket close to the DNA exit site. This domain shows flexibility with respect to the fixed zinc finger and moves with, but also relative to, the unwrapped DNA terminus. We apply molecular dynamics simulations of the histone tails in the nucleosome to show that in this mode of interaction, the active site of SIRT6 is perfectly poised to catalyze deacetylation of the H3 histone tail and that the partial unwrapping of the DNA allows even lysines close to the H3 core to reach the enzyme.
Comparative Interactome Analysis of α-arrestin Families in Human and Drosophila
Authors: Lee Kyung-Tae , Pranoto Inez K.A. , Kim Soon-Young , Choi Hee-Joo , To Ngoc Bao , Chae Hansong , Lee Jeong-Yeon , Kim Jung-Eun , Kwon Young V. , Nam Jin-Wu
Published: December 2023

The α-arrestins form a large family of evolutionally conserved modulators that control diverse signaling pathways, including both G-protein-coupled receptor-(GPCR-) mediated and non-GPCR mediated pathways, across eukaryotes. However, unlike β-arrestins, only a few α-arrestin targets and functions have been characterized. Here, using affinity purification and mass spectrometry, we constructed interactomes for six human and twelve
Drosophila
α-arrestins. The resulting high-confidence interactomes comprised 307 and 467 prey proteins in human and
Drosophila
, respectively. A comparative analysis of these interactomes predicted not only conserved binding partners, such as motor proteins, proteases, ubiquitin ligases, RNA splicing factors, and GTPase-activating proteins, but also those specific to mammals, such as histone modifiers and the subunits of V-type ATPase. Given the manifestation of the interaction between the human α-arrestin, TXNIP, and the histone-modifying enzymes, including HDAC2, we undertook a global analysis of transcription signals and chromatin structures that were affected by TXNIP knockdown. We found that TXNIP activated targets by blocking HDAC2 recruitment to targets, a result that was validated by chromatin immunoprecipitation assays. Additionally, the interactome for an uncharacterized human α-arrestin ARRDC5 uncovered multiple components in the V-type ATPase, which plays a key role in bone resorption by osteoclasts. Our study presents conserved and species-specific protein-protein interaction maps for α-arrestins, which provide a valuable resource for interrogating their cellular functions for both basic and clinical research.
The reciprocal regulation between mitochondrial-associated membranes and Notch signaling in skeletal muscle atrophy
Authors: Ito Yurika , Yamagata Mari , Yamamoto Takuya , Hirasaka Katsuya , Nikawa Takeshi , Sato Takahiko
Published: December 2023

Skeletal muscle atrophy and the inhibition of muscle regeneration are known to occur as a natural consequence of aging, yet the underlying mechanisms that lead to these processes in atrophic myofibers remain largely unclear. Our research has revealed that the maintenance of proper mitochondrial-associated endoplasmic reticulum membranes (MAM) is vital for preventing skeletal muscle atrophy in microgravity environments. We discovered that the deletion of the mitochondrial fusion protein Mitofusin2 (MFN2), which serves as a tether for MAM, in human iPS cells or the reduction of MAM in differentiated myotubes caused by microgravity interfered with myogenic differentiation process and an increased susceptibility to muscle atrophy, as well as the activation of the Notch signaling pathway. The atrophic phenotype of differentiated myotubes in microgravity and the regenerative capacity of Mfn2-deficient muscle stem cells in dystrophic mice were both ameliorated by treatment with the gamma-secretase inhibitor DAPT. Our findings demonstrate how the orchestration of mitochondrial morphology in differentiated myotubes and regenerating muscle stem cells plays a crucial role in regulating Notch signaling through the interaction of MAM.This study investigated the link between Mfn2 and Notch signaling in skeletal muscle atrophy. We used a microgravity system to induce muscle atrophy and found that the loss of Mfn2 leads to decreased numbers of MAM and activation of Notch signaling and that treating MFN2-deficient human iPS cells with a gamma-secretase inhibitor DAPT improved their mitochondrial morphology and function. Additionally, Mfn2-deficient muscle stem cells in mice have a lower capacity to regenerate dystrophic muscles and DAPT treatment improves the regeneration of these cells. The study suggests that targeting the Notch signaling pathway with a gamma-secretase inhibitor could be a therapeutic option for skeletal muscle atrophy caused by defects in Mfn2.
A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria
Authors: Faniyan Tumininu S. , Zhang Xinyi , Morgan Donald A. , Robles Jorge , Bathina Siresha , Brookes Paul S. , Rahmouni Kamal , Perry Rachel J. , Chhabra Kavaljit H.
Published: December 2023

The kidneys facilitate energy conservation through reabsorption of nutrients including glucose. Almost all of the filtered blood glucose is reabsorbed by the kidneys. Loss of glucose in urine (glycosuria) is offset by an increase in endogenous glucose production to maintain normal energy supply in the body. How the body senses this glucose loss and consequently enhances glucose production is unclear. Using renal
Glut2
knockout mice, we demonstrate that elevated glycosuria activates the hypothalamic-pituitary-adrenal axis, which in turn drives endogenous glucose production. This phenotype was attenuated by selective afferent renal denervation, indicating the involvement of the afferent nerves in promoting the compensatory increase in glucose production. In addition, through plasma proteomics analyses we observed that acute phase proteins - which are usually involved in body’s defense mechanisms against a threat – were the top candidates which were either upregulated or downregulated in renal
Glut2
KO mice. Overall, afferent renal nerves contribute to promoting endogenous glucose production in response to elevated glycosuria and loss of glucose in urine is sensed as a biological threat in mice. These findings may be useful in improving efficiency of drugs like SGLT2 inhibitors that are intended to treat hyperglycemia by enhancing glycosuria, but are met with a compensatory increase in endogenous glucose production.
Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia
Authors: Zhu Bohan , Ainsworth Richard I. , Wang Zengmiao , Liu Zhengzhi , Sierra Salvador , Deng Chengyu , Callado Luis F. , Meana J. Javier , Wang Wei , Lu Chang , González-Maeso Javier
Published: December 2023

Genome-wide association studies have revealed >270 loci associated with schizophrenia risk, yet these genetic factors do not seem to be sufficient to fully explain the molecular determinants behind this psychiatric condition. Epigenetic marks such as post-translational histone modifications remain largely plastic during development and adulthood, allowing a dynamic impact of environmental factors, including antipsychotic medications, on access to genes and regulatory elements. However, few studies so far have profiled cell-specific genome-wide histone modifications in postmortem brain samples from schizophrenia subjects, or the effect of antipsychotic treatment on such epigenetic marks. Here we performed ChIP-seq and RNA-seq on frontal cortex samples from individuals with schizophrenia that were antipsychotic-free (AF) or antipsychotic-treated (AT), and individually matched controls (n=58). Schizophrenia subjects exhibited thousands of neuronal vs non-neuronal epigenetic differences at regions that included several susceptibility genetic loci, such as
NRG1
,
DISC1,
and
DRD3
. By analyzing the AF and AT cohorts separately, we identified schizophrenia-associated alterations in specific transcription factors, their regulatees, and epigenomic and transcriptomic features that were reversed by antipsychotic treatment; as well as those that represented a consequence of antipsychotic medication rather that a hallmark of schizophrenia in postmortem human brain samples. Notably, we also found that the effect of age on epigenomic landscapes was more pronounced in frontal cortex of AT-schizophrenics, as compared to AF-schizophrenics and controls. Together, these data provide important evidence of epigenetic alterations in the frontal cortex of individuals with schizophrenia, and remark for the first time the impact of age and antipsychotic treatment on chromatin organization.
A latent clinical-anatomical dimension relating metabolic syndrome to brain structure and cognition
Authors: Petersen Marvin , Hoffstaedter Felix , Nägele Felix L. , Mayer Carola , Schell Maximilian , Rimmele D. Leander , Zyriax Birgit-Christiane , Zeller Tanja , Kühn Simone , Gallinat Jürgen , Fiehler Jens , Twerenbold Raphael , Omidvarnia Amir , Patil Kaustubh R. , Eickhoff Simon B. , Thomalla Götz , Cheng Bastian
Published: December 2023

The link between metabolic syndrome (MetS) and neurodegenerative as well cerebrovascular conditions holds substantial implications for brain health in at-risk populations. This study elucidates the complex relationship between metabolic syndrome (MetS) and brain health by conducting a comprehensive examination of cardiometabolic risk factors, cortical morphology, and cognitive function in 40,087 individuals. Multivariate, data-driven statistics identified a latent dimension linking more severe MetS to widespread cortical abnormalities and lower cognitive performance, accounting for up to 77% of shared variance in the data. This dimension was replicable across sub-samples. Our results also suggest that MetS-related cortical effects are shaped by the regional cellular composition and macroscopic brain network organization. By leveraging extensive, multi-domain data combined with a dimensional stratification approach, our analysis provides profound insights into the association of MetS and brain health. These findings underscore the necessity for effective risk mitigation strategies aimed at maintaining brain integrity.
Bilsem ve Proje Okullarına Devam Eden Ortaöğretim Öğrencilerinde Hataya Karşı Utanç ve Suçluluk ile Öz Güven Arasındaki İlişkinin İncelenmesi
Authors: GÜNER EŞERLER İlkay , GÜNGÖR Halime , DİLBER Yaşar
Published: December 2023

Bu araştırmanın amacı Bursa ili bilim ve sanat merkezleri ile proje okullarında öğrenim gören lise öğrencilerinin hataya karşı suçluluk ve öz güven düzeyleri arasındaki ilişkinin belirlenmesidir. Araştırma tarama modelinde betimsel bir araştırmadır. Nicel araştırma deseni kullanılmıştır. Araştırma örneklemini 2021-2022 istatistiklerine göre Bursa ilinde bilim ve sanat merkezleri ve proje okullarında öğrenim gören 705 lise öğrencisi oluşturmaktadır. Araştırma Bursa ilinde bilim ve sanat merkezleri ve proje okullarında öğrenim gören lise öğrencilerine yönelik olduğu için amaçlı örnekleme yöntemi kullanılmış, gönüllülük esas alınmıştır. Araştırmada Kişisel Bilgi Formu, Hatayla İlişkili Utanç ve Suçluluk Duygusu Ölçeği ve Öz Güven Ölçeği veri toplama aracı olarak kullanılmıştır. Öğrencilerin hataya ilişkin utanç ve suçluluk duygusuna ve alt boyutları olan utanç ve suçluluğa ilişkin algılarının cinsiyete göre istatistiksel olarak anlamlı olarak farklılaştığı, kız öğrencilerin utanç, suçluluk ve hataya ilişkin utanç ve suçluluk duygusuna yönelik algılarının erkek öğrencilere göre daha yüksek olduğu görülmektedir. Öğrencilerin hataya karşı utanç ve suçluluk ile öz güven duygusuna ilişkin algılarının Bilsem’e devam durumuna göre istatistiksel olarak anlamlı olarak farklılaşmadığı görülmektedir. Öz güven ve öz güvenin alt boyutları olan iç öz güven ve dış öz güven ile hataya ilişkin utanç ve suçluluk duygusu ve öz güven arasında düşük düzey negatif ilişki olduğu, öğrencilerinin öz güvenleri arttıkça hataya karşı utanç ve suçluluk duygularının azaldığı, öz güvenleri azaldıkça hataya karşı utanç ve suçluluk duygularının arttığı söylenebilir.
Analysis Of Farmer's Attitude Towards Farmers Producer Organizations (FPOs) in Eastern Uttar Pradesh, India
Authors: Singh Abhinav , Doharey R. K. , Singh Ritesh , Shudhanshu
Published: December 2023

The study was carried out in Gorakhpur and Basti District of eastern region of Uttar Pradesh state by conducting a personal interview with 400 FPOs members those were selected through proportionate random sampling technique from 10 FPOs and 20 members were selected from each of the FPO. The study was carried out under objective "To study the analysis of farmer's attitude towards farmers producer organizations." Out of 400 respondents 52.25 per cent respondents have high level of attitude towards FPOs followed by 34.50 per cent medium and 13.25 per cent have low level of attitude. The average mean of attitude observed to be 58.72 with a range of minimum 40 and maximum 74.
Calibration and Validation of DSSAT (CROPGRO) Model for Winter Irrigated Cotton in Coimbatore, Tamil Nadu, India
Authors: Khatua Rajashree , Panneerselvam S. , Geethalakshmi V. , Kumar M.  , Jeyakumar P.
Published: December 2023

Crop simulation model is used for predicting the crop productivity under various crop management practices and find out the yield gap of cotton crop, that require determination of genetic coefficient of a crop cultivar. Successful use of a crop model depends on the accuracy of calibration and validation of different parameters. This paper aimed to evaluate the DSSAT model using experimental data on the different nutrient management practices for cotton and calibrated and validated the data by using DSSAT (CROPGRO) model. The field experiment was conducted at Cotton Breeding Station, TNAU, Coimbatore from 2018 to 2020 in winter irrigated season (August-January). The GNECAL tool from DSSAT was used to calibrate the CO17 variety of cotton. The yield and yield attributes, phonological stags, harvest index and biomass as simulated by model were compared with the observed data. The results for model predictions showed that the simulated growth and development of cotton were in good agreement with their corresponding observed values. The CROPGRO model can be successfully used for simulating the growth and yield of crop for major cotton growing regions in Tamil Nadu.
Bifunctional Iminophosphorane Catalyzed Amide Enolization for Enantioselective Cyclohexadienone Desymmetrization
Authors: Poh Charmaine Y. X. , Rozsar Daniel , Yang Jinchao , Christensen Kirsten E. , Dixon Darren J.
Published: December 2023

The organocatalytic enolization of 2‐arylacetamides, followed by an enantioselective intramolecular conjugate addition to tethered 2,5‐cyclohexadienones, yielding 3D fused N‐heterocycles, is described. The transformation represents the first strong activating group‐free activation of carboxamides via α‐C−H deprotonation in a metal‐free, catalytic, and enantioselective reaction, and is achieved by employing a bifunctional iminophosphorane (BIMP) superbase.
C/CLAY® – Experiences with clay calcining and grinding to achieve high SCM rates
Authors: Trümer André , Reformat Martin , de Pinho Luiz Felipe
Published: December 2023

The cement industry has committed to take drastic steps to reduce process‐related CO2 emissions to achieve climate neutrality by 2050. One essential part of the solution is the reduction of the average clinker content in cement. However, the limits of availability of common composite materials are already reached, and focus is laid meanwhile on calcined clays as the next generation SCM. The knowledge about the effects of calcined clay in cement and also the development of production technologies are well‐advanced. Now it is the task to earn acceptance on customer's side project by project.

For that purpose, the presented paper sums up the state of the art of clay activation by answering the most urgent questions of clients. This also includes a review of LOESCHE's experiences with clay calcination and grinding gained in the recent years. LOESCHE combines its competence in this technology in the product C/CLAY® supplying individual solutions for all process steps from pretreatment over calcination to finish grinding. The most practical C/CLAY® methods, the flash‐calcination and rotary kiln firing, are explained with their complete process chains, whereby the latter provides a suitable option for retrofitting stopped cement production lines. As example, the layout of the world's biggest clay calcination plant designed by LOESCHE's subsidiary DYNAMIS is presented.
Modular concrete structures for the restoration of destroyed residential buildings in Ukraine
Authors: Fedorenko Yuliia , Sopov Viktor
Published: December 2023

Since the beginning of the military invasion by Russia on February 24, 2022 and subsequent hostilities in Ukraine, approximately 140,000 residential buildings (of which around 18,000 are apartment buildings) have been destroyed or damaged. Destructions require a systematic approach to the restoration or construction of new buildings. This article analyzes the types of destruction of multi‐story prefabricated reinforced concrete residential buildings and proposed methods for restoration of damaged and partially destroyed high‐rise buildings. Improved modular concrete structures developed from high‐performance concrete and different variations of rebar can significantly speed up the recovery of affected regions.
Elektrisch beheizbarer textilbewehrter Carbonbeton
Authors: Dahlhoff Annette , Raupach Michael
Published: December 2023

Kurzfassung

Textilbewehrter Carbonbeton wird derzeit in vielen Bereichen der Bauindustrie als Hochleistungsverbundwerkstoff eingesetzt. Der Verbundwerkstoff besteht aus Beton und einer nicht‐metallischen Bewehrung aus Carbonfasern in Stab‐ oder Gitterform. Der innovative Werkstoff hat neben vielversprechenden Materialeigenschaften wie Zugverhalten und der Dichte auch eine hohe elektrische Leitfähigkeit. Die letztgenannte Eigenschaft kann genutzt werden, um Wärme im Bauteil zu erzeugen und dadurch z.B. im Verbundwerkstoff den Hydratationsprozess des Betons zu beschleunigen. Zur Verwendung der elektrisch leitenden textilen Carbonbewehrung wurden baustellentaugliche Kontaktierungsverfahren für unterschiedliche Tränkungsmaterialien entwickelt und bewertet, sowie die elektrischen Eigenschaften wie Leistung und Carbonwiderstand der verwendeten Carbonbewehrungen bestimmt. Darauf aufbauend wurde die Temperaturverteilung der Bewehrungen in Abhängigkeit unterschiedlicher Stromflüsse untersucht. Die Untersuchungen ermöglichten die Quantifizierung und Charakterisierung des Einflusses des Tränkungsmaterials sowie der Geometrie des Faserstranges auf die Strom‐ und Temperaturverteilungen.
Phase formation of oil‐well cements based on chemical industry wastes
Authors: Korohodska Alla , Shabanova Halyna , Logvinkov Sergii , Deviatova Natalia
Published: December 2023

The crystalline compounds CaAl2O4 and Ca12Al14O33 are reliably identified by electron microscopic and X‐ray studies of the structural and phase features of clinker, and the iron‐ and chromium‐containing phases are presented in the form of solid solutions: Ca2Al0.48Fe1.52O5 and Ca5(CrO4)(CrO4)2. This allows creating of a heat‐resistant, strong, weighted oil‐well cement for cementing “hot” oil and gas wells. It has been found that obtained materials have enhanced strength – compressive strength after 28 days of setting reaches 55 MPa, quick‐setting – initial set – 2 hours 55 minutes, final set – 4 hours 20 minutes, quick‐setting – compressive strength after 3 days of setting reaches 48.6 MPa, bending strength reaches 6.7 MPa; and are hydraulic binders with water‐cement ratio of 0.17 – 0.38; with high sulfate resistance ratio of 1.31 which is 1.5 times higher than that of Portland cement.
Sulfoalithaltiger Portlandzementklinker für leistungsfähige Zemente
Authors: Lörke Paul , Ludwig Horst‐Michael , Lörke Alexander
Published: December 2023

Der auf Basis von sulfoalithaltigen Portlandzementklinkern hergestellte Zement ist ein neuer Typ von Portlandzementen mit universellen Gebrauchseigenschaften, der im Gegensatz zu den üblichen Zementen ohne Zusätze zumindest den Sulfoalit unter den anderen Sulfomineralen enthält. Im Rahmen der Untersuchung wurden kleine Mengen sulfomineralhaltige Portlandzementklinker mit extrem unterschiedlicher chemisch‐mineralogischer Zusammensetzung bei mehreren Zementwerken industriell hergestellt. Zur Bewertung der thermischen Stabilität von Sulfomineralien und des Calciumsulfats wurden thermodynamische Untersuchungen durchgeführt. Es wurde dabei folgende Faktoren berücksichtigt: Abhängigkeiten von der Zusammensetzung des Gasmediums, d. h. von der CO‐, SO3‐, CO2‐ und H2‐Gehalte in den Ofengasen beim Vorhandensein im Brenngut der freibleibenden sauren (SiO2, Al2O3, Fe2O3, TiO2, Cr2O3, P2O5) und basischen (Na2O, K2O, MgO) Oxide in einem Temperaturbereich zwischen 900 und 1300° C, in dem vorübergehend Zwischenmineralien, wie CF, CS, C3S2, CA, C2A, C2SA, existieren. Außerdem wurde thermodynamisch die Bildung von Sulfomineralien aus dem Calciumsulfat und Klinkermineralien bewertet.
Influence of iron doped TiO2 nanotubes on the hydration of tricalcium silicate
Authors: Qattali S. Mohd. Yonos , Pritzel Christian , Kowald Torsten , Moni S. M. Fuad Kabir , Trettin Reinhard , Killian Manuela S.
Published: December 2023

Environmental pollution is one of biggest challenges facing the world. The promising technology to control this problem is utilization of semiconductor materials as photocatalyst. It is well known that normal TiO2 showing photocatalytic activity in the UV light, so to decrease the band gap and shifting into visible light, titanium dioxide nanotubes was doped with Fe3+ ions. The influence of fabricated Fe‐doped TiO2 nanotubes (Fe/TiNTs) on the hydration of tricalcium silicate (C3S) have been studied. Addition of 1.0 wt%, 2.0 wt% and 3.0 wt% of Fe/TiNTs into C3S system significantly accelerated the course of hydration. Study on the hydration products after 8h, 1d and 7d improved the degree of hydration. The enhancing of compressive strength of hydrated C3S after 7d, 14d and 28d was observed comparing to the normal TiO2 nanotubes (TiNTs). Also treating both Fe/TiNTs and TiNTs with supersaturated Ca(OH)2 solution revealed a strong interaction between Ca2+‐ ions and nanotubes particularly in the presence of iron (Fe/TiNTs). The specific surface area of hydration products in the presence of Fe/TiNTs was increased. In this study, isothermal calorimetry was utilized for the course of hydration, x‐ ray powder diffraction (XRD) for the phase composition in combination with simultaneous thermal analysis (STA) and gas adsorption (GA) for measuring specific surface area of nanotubes and hydration products.