bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Resin Bonding on Long-Term Success of High-Strength Ceramics
Authors: Blatz M.B. , Vonderheide M. , Conejo J.
Published: September 2017

Digital manufacturing, all-ceramics, and adhesive dentistry are currently the trendiest topics in clinical restorative dentistry. Tooth- and implant-supported fixed restorations from computer-aided design (CAD)/computer-aided manufacturing (CAM)–fabricated high-strength ceramics—namely, alumina and zirconia—are widely accepted as reliable alternatives to traditional metal-ceramic restorations. Most recent developments have focused on high-translucent monolithic full-contour zirconia restorations, which have become extremely popular in a short period of time, due to physical strength, CAD/CAM fabrication, and low cost. However, questions about proper resin bonding protocols have emerged, as they are critical for clinical success of brittle ceramics and treatment options that rely on adhesive bonds, specifically resin-bonded fixed dental prostheses or partial-coverage restorations such as inlays/onlays and veneers. Resin bonding has long been the gold standard for retention and reinforcement of low- to medium-strength silica-based ceramics but requires multiple pretreatment steps of the bonding surfaces, increasing complexity, and technique sensitivity compared to conventional cementation. Here, we critically review and discuss the evidence on resin bonding related to long-term clinical outcomes of tooth- and implant-supported high-strength ceramic restorations. Based on a targeted literature search, clinical long-term studies indicate that porcelain-veneered alumina or zirconia full-coverage crowns and fixed dental prostheses have high long-term survival rates when inserted with conventional cements. However, most of the selected studies recommend resin bonding and suggest even greater success with composite resins or self-adhesive resin cements, especially for implant-supported restorations. High-strength ceramic resin-bonded fixed dental prostheses have high long-term clinical success rates, especially when designed as a cantilever with only 1 retainer. Proper pretreatment of the bonding surfaces and application of primers or composite resins that contain special adhesive monomers are necessary. To date, there are no clinical long-term data on resin bonding of partial-coverage high-strength ceramic or monolithic zirconia restorations.
Photoacoustic Imaging for Noninvasive Periodontal Probing Depth Measurements
Authors: Lin C.Y. , Chen F. , Hariri A. , Chen C.J. , Wilder-Smith P. , Takesh T. , Jokerst J.V.
Published: September 2017

The periodontal probe is the gold standard tool for periodontal examinations, including probing depth measurements, but is limited by systematic and random errors. Here, we used photoacoustic ultrasound for high–spatial resolution imaging of probing depths. Specific contrast from dental pockets was achieved with food-grade cuttlefish ink as a contrast medium. Here, 39 porcine teeth (12 teeth with artificially deeper pockets) were treated with the contrast agent, and the probing depths were measured with novel photoacoustic imaging and a Williams periodontal probe. There were statistically significant differences between the 2 measurement approaches for distal, lingual, and buccal sites but not mesial. Bland-Altman analysis revealed that all bias values were < ±0.25 mm, and the coefficients of variation for 5 replicates were <11%. The photoacoustic imaging approach also offered 0.01-mm precision and could cover the entire pocket, as opposed to the probe-based approach, which is limited to only a few sites. This report is the first to use photoacoustic imaging for probing depth measurements with potential implications to the dental field, including tools for automated dental examinations or noninvasive examinations.
Attitudes of Undergraduate Students Toward Persons With Disabilities: Exploring Effects of Contact Experience on Social Distance Across Ten Disability Types
Authors: Huskin Patricia R. , Reiser-Robbins Christine , Kwon Soyoung
Published: September 2017

Attitudes toward individuals with disabilities have been one of the most important and focal topics in disability studies. However, most studies have either treated disability in a broad sense without distinguishing disability type or have been limited to one specific disability type. Drawing upon a social distance scale, the study was designed to examine undergraduate students’ perceptions toward 10 different disability types and across a range of social contexts. Utilizing intergroup contact theory, an analysis was performed to determine how these responses were affected by contact experience with persons with disability. Results show that contact experience was statistically significant for six of 10 disability types. Specifically, across all disabilities, regular contact was related to decreased social distance, with the notable exception of autism. Attendant conclusions about stigma hierarchies and implications for research and practice are discussed.
Rheological studies of functional polyurethane composite with solid additives
Authors: Oxley Jimmie C , Smith James L , Bakhtiyarov Sayavur I , Baldovi Philipp M
Published: September 2017

The rheological dynamic characteristics of the functional polyurethane foam composite with solid additives (calcium iodate particles, aluminum flakes) were experimentally measured using an oscillatory rotational rheometer ARES-G2. Our previous studies demonstrated that the presence of the gas bubbles alters the rheology of the continuous liquid phase. The experimental tests results show that the apparent viscosity (the shear stress applied to a fluid divided by the shear rate) of the two-phase mixture increases with the concentration of the aluminum additive and decreases with the temperature rise. The rheological measurements showed that the functional foam exhibits a strong time-dependent and thixotropic (shear thinning) behavior. The rheological behavior of this composite can be described with the power law–generalized non-Newtonian fluid model. The apparent viscosity of the polyurethane increases with both the testing time (exponentially) and the solid content (polynomial) in the mixture. The measured rheological characteristics of the polyurethane-based functional foam will be helpful for material designers and developers.
The people in the ‘here and now’: Populism, modernization and the state in Greece
Authors: Chryssogelos Angelos
Published: September 2017

The term ‘populism’ has gained renewed prominence in Greece during the Eurozone crisis, in both public and academic debates. In this article I conceptualize populism as a discourse of territorial and temporal particularism, which challenges the way a state has been incorporated into the international political and economic system. Based on this definition, I question whether oppositional discourses employed by partisan actors or official power are wholesale and genuine expressions of populism. Thus, I contest the notion that Greece failed due to populism. Instead I draw attention to a failure in the official legitimation of modernization by state elites that long preceded the crisis.
Distinct sensitivity to caffeine-induced insomnia related to age
Authors: Frozi Júlia , de Carvalho Hudson W , Ottoni Gustavo L , Cunha Rodrigo A , Lara Diogo R
Published: September 2017

Caffeine acts by antagonizing the effect of the endogenous homeostatic sleep factor adenosine. In the current study we aimed to evaluate the pattern of caffeine-induced insomnia and its relation to age and sex in a general population sample derived from a web survey. The sample included 75,534 participants (28.1% men) from 18 to 75 years who answered self-report questionnaires by accessing a website in Brazilian Portuguese (BRAINSTEP project). In our sample, 3620 (17.0%) men and 9920 (18.3%) women reported insomnia due to caffeine intake. Caffeine-induced insomnia increased with aging in both men and women. This difference remained after adjusting for sociodemographic, psychiatric and sleep related variables as well as caffeine intake. Women showed higher proportion of caffeine-induced insomnia than men, but this difference did not remain after controlling for covariates. Also, individuals with caffeine-induced insomnia reported poorer sleep quality, higher latency to fall asleep and a higher proportion of psychiatric diagnoses and daily use of hypnotic drugs. In conclusion, our results show an age-associated increase in caffeine-induced insomnia and poorer mental health indicators among people with caffeine-induced insomnia complaints.
Analysis of acute naproxen administration on memory in young adults: A randomized, double-blind, placebo-controlled study
Authors: Wilson Jack H , Criss Amy H , Spangler Sean A , Walukevich Katherine , Hewett Sandra
Published: September 2017

Nonsteroidal anti-inflammatory drugs work by non-selectively inhibiting cyclooxygenase enzymes. Evidence indicates that metabolites of the cyclooxygenase pathway play a critical role in the process of learning and memory. We evaluated whether acute naproxen treatment impairs short-term working memory, episodic memory, or semantic memory in a young, healthy adult population. Participants received a single dose of placebo or naproxen (750 mg) in random order separated by 7–10 days. Two hours following administration, participants completed five memory tasks. The administration of acute high-dose naproxen had no effect on memory in healthy young adults.
The future approach
Authors: Woolf Steven
Published: September 2017

This Opinion considers a new approach that has been adopted by various local authorities who have successfully applied for injunctive relief to prevent ‘persons unknown’ from setting up encampments on any green spaces identified on a local authority map. It is suggested that the ‘preventative injunction’ is a better way to deal with traveller encampments on green spaces, as it is proactive rather than reactive. It is of particular benefit, when having regard to the huge sums of money that councils have expended on addressing the arrival of travellers in their areas. Local authorities have limited resources (time and money) and it is argued that this approach could instead help them to obviously spend the money saved to enhance the ‘quality of life’ of their local residents.
The Optimal Location to Measure Scapholunate Diastasis on Screening Radiographs
Authors: Said Joseph , Baker Kevin , Fernandez Laviel , Komatsu David E. , Gould Elaine , Hurst Lawrence C.
Published: September 2017

Background: Lack of a universally accepted location and normal value limits the utility of measuring scapholunate diastasis. The primary purpose of this study was to define the optimal location to measure the scapholunate gap throughout sequential ligament transections. Secondary purposes were to compare plain radiographs with fluoroscopy and to evaluate interrater reliability in measuring scapholunate diastasis. Methods: Five cadaver forearms were imaged with intact carpal ligaments and after sequentially transecting the scapholunate, radioscaphocapitate, and scaphotrapezium-trapezoid ligaments. Plain radiographs and static fluoroscopic images were obtained with wrists in neutral and 30° ulnar deviation for each stage. Multiple reviewers performed measurements of the scapholunate interval at 3 separate locations. Mean distances were calculated and pairwise comparisons between groups were made. Intraclass correlation was calculated to determine interrater reliability. Results: Overall, measurements made in the middle of the scapholunate joint had the smallest margins of error for all imaging modalities, ligament disruptions, and wrist positions. For normal wrists, the mean scapholunate measurements were all less than 2.0 mm at the middle of the joint, regardless of imaging modality or wrist position. Fluoroscopy detected significance between more stages of instability than plain radiographs at the middle of the joint. Conclusions: Measurements in the middle of the scapholunate joint in neutral and 30° of ulnar deviation under fluoroscopic imaging best capture all stages of ligamentous disruptions. Measurements less than 2.0 mm at the middle of the scapholunate interval may be considered within normal range.
Dysphagia screening after intracerebral hemorrhage
Authors: Joundi Raed A , Martino Rosemary , Saposnik Gustavo , Giannakeas Vasily , Fang Jiming , Kapral Moira K
Published: September 2017

Background

Dysphagia screening is recommended after acute stroke to identify patients at risk of aspiration and implement appropriate care. However, little is known about the frequency and outcomes of patients undergoing dysphagia screening after intracerebral hemorrhage (ICH).

Methods

We used the Ontario Stroke Registry from 1 April 2010 to 31 March 2013 to identify patients hospitalized with acute stroke and to compare dysphagia screening rates in those with ICH and ischemic stroke. In patients with ICH we assessed predictors of receiving dysphagia screening, predictors of failing screening, and outcomes after failing screening.

Results

Among 1091 eligible patients with ICH, 354 (32.4%) patients did not have documented dysphagia screening. Patients with mild ICH were less likely to receive screening (40.4% of patients were omitted, adjusted odds ratio (aOR) 0.40, 95% confidence interval (CI) 0.26–0.63). Older age, greater stroke severity, speech deficits, lower initial level of consciousness, and admission to intensive care unit were predictive of failing the screening test. Failing screening was associated with poor outcomes, including pneumonia (aOR 5.3, 95% CI 2.36–11.88), severe disability (aOR 4.78, 95% CI 3.08–7.41), and 1-year mortality (adjusted hazard ratio 2.1, 95% CI 1.38–3.17). When compared to patients with ischemic stroke, patients with ICH were less likely to receive dysphagia screening (aOR 0.64, 95% CI 0.54–0.76) and more likely to fail screening (aOR 1.98, 95% 1.62–2.42).

Conclusion

One-third of patients with ICH did not have documented dysphagia screening, increasing to 40% in patients with mild clinical severity. Failing screening was associated with poor outcomes. Patients with ICH were less like to receive screening and twice as likely to fail compared to patients with ischemic stroke, and thus efforts should be made to include ICH patients in dysphagia screening protocols whenever possible.
How Efficient Are Emotional Intelligence Trainings: A Meta-Analysis
Authors: Hodzic Sabina , Scharfen Jana , Ripoll Pilar , Holling Heinz , Zenasni Franck
Published: September 2017

This multilevel meta-analysis examines whether emotional intelligence (EI) can be enhanced through training and identifies training effects’ determinants. We identified 24 studies containing 28 samples aiming at increasing individual-level EI among healthy adults. The results revealed a significant moderate standardized mean change between pre- and post-measurement for the main effect of EI training, and a stable pre- to follow-up effect. Additionally, the type of EI model, dimensions of the four branch model, length, and type of publication turned out to be significant moderators. The results suggest that EI trainings should be considered effective interventions.
Percutaneous extracorporeal membrane oxygenation in electrical storm: five case reports addressing efficacy, transferring allowance or radiofrequency ablation support
Authors: Uribarri Aitor , Bravo Loreto , Jimenez-Candil Javier , Martin-Moreiras Javier , Villacorta Eduardo , Sanchez Pedro L
Published: September 2017

Extracorporeal membrane oxygenation systems have undergone rapid technological improvements and are now feasible options for medium-term support of severe cardiac or pulmonary failure. We report five cases of electrical storm that was rescued by the insertion of peripheral veno-arterial extracorporeal membrane oxygenation systems. This device could help to restore systemic circulation as well as permitting organ perfusion in patients with cardiogenic shock in relation to electrical storm thus achieving greater electrical stability. Also, in some cases extracorporeal membrane oxygenation support could facilitate electrophysiology study.
Measurements of glucose concentration in aqueous solutions using reflected THz radiation for applications to a novel sub-THz radiation non-invasive blood sugar measurement method
Authors: Torii Teruaki , Chiba Hironori , Tanabe Tadao , Oyama Yutaka
Published: September 2017

The terahertz (THz) frequency range corresponds to molecular vibrations or relaxation modes such as those for the hydrogen bond. Most biomolecules are activated only in aqueous solutions, thus, to understand the function and structure of biomolecules, it is necessary to investigate the characteristics of electromagnetic waves in hydrated samples. THz radiation causes little damage to the human body, thus it is expected that it can be applied for noninvasive examinations. However, spectrometry of the transmitted light is difficult, since the absorption of THz radiation in water is extremely high. In this study, we used sub-THz radiation (frequencies near to 0.1 THz), where the absorption is lower than for THz radiation, to measure the reflectance of a glucose water solution. We found that the reflectance decreases in proportion with the glucose concentration. These results suggest that sub-THz radiation can be used in the noninvasive measurement of blood glucose levels.
Autobiographical memory: A candidate latent vulnerability mechanism for psychiatric disorder following childhood maltreatment
Authors: McCrory Eamon J. , Puetz Vanessa B. , Maguire Eleanor A. , Mechelli Andrea , Palmer Amy , Gerin Mattia I. , Kelly Philip A. , Koutoufa Iakovina , Viding Essi
Published: September 2017

Background

Altered autobiographical memory (ABM) functioning has been implicated in the pathogenesis of depression and posttraumatic stress disorder and may represent one mechanism by which childhood maltreatment elevates psychiatric risk.

Aims

To investigate the impact of childhood maltreatment on ABM functioning.

Method

Thirty-four children with documented maltreatment and 33 matched controls recalled specific ABMs in response to emotionally valenced cue words during functional magnetic resonance imaging.

Results

Children with maltreatment experience showed reduced hippocampal and increased middle temporal and parahippocampal activation during positive ABM recall compared with peers. During negative ABM recall they exhibited increased amygdala activation, and greater amygdala connectivity with the salience network.

Conclusions

Childhood maltreatment is associated with altered ABM functioning, specifically reduced activation in areas encoding specification of positive memories, and greater activation of the salience network for negative memories. This pattern may confer latent vulnerability to future depression and posttraumatic stress disorder.
Delineating the Trajectory of Cognitive Recovery From General Anesthesia in Older Adults: Design and Rationale of the TORIE (Trajectory of Recovery in the Elderly) Project
Authors: Mincer Joshua S. , Baxter Mark G. , McCormick Patrick J. , Sano Mary , Schwartz Arthur E. , Brallier Jess W. , Allore Heather G. , Delman Bradley N. , Sewell Margaret C. , Kundu Prantik , Tang Cheuk Ying , Sanchez Angela , Deiner Stacie G.
Published: September 2017

BACKGROUND:

Mechanistic aspects of cognitive recovery after anesthesia and surgery are not yet well characterized, but may be vital to distinguishing the contributions of anesthesia and surgery in cognitive complications common in the elderly such as delirium and postoperative cognitive dysfunction. This article describes the aims and methodological approach to the ongoing study, Trajectory of Recovery in the Elderly (TORIE), which focuses on the trajectory of cognitive recovery from general anesthesia.

METHODS:

The study design employs cognitive testing coupled with neuroimaging techniques such as functional magnetic resonance imaging, diffusion tensor imaging, and arterial spin labeling to characterize cognitive recovery from anesthesia and its biological correlates. Applying these techniques to a cohort of age-specified healthy volunteers 40–80 years of age, who are exposed to general anesthesia alone, in the absence of surgery, will assess cognitive and functional neural network recovery after anesthesia. Imaging data are acquired before, during, and immediately after anesthesia, as well as 1 and 7 days after. Detailed cognitive data are captured at the same time points as well as 30 days after anesthesia, and brief cognitive assessments are repeated at 6 and 12 months after anesthesia.

RESULTS:

The study is underway. Our primary hypothesis is that older adults may require significantly longer to achieve cognitive recovery, measured by Postoperative Quality of Recovery Scale cognitive domain, than younger adults in the immediate postanesthesia period, but all will fully recover to baseline levels within 30 days of anesthesia exposure. Imaging data will address systems neuroscience correlates of cognitive recovery from general anesthesia.

CONCLUSIONS:

The data acquired in this project will have both clinical and theoretical relevance regardless of the outcome by delineating the mechanism behind short-term recovery across the adult age lifespan, which will have major implications for our understanding of the effects of anesthetic drugs.
Mitochondrial dynamics in Parkinson's disease: a role for α-synuclein?
Authors: Pozo Devoto Victorio M. , Falzone Tomas L.
Published: September 2017

The distinctive pathological hallmarks of Parkinson's disease are the progressive death of dopaminergic neurons and the intracellular accumulation of Lewy bodies enriched in α-synuclein protein. Several lines of evidence from the study of sporadic, familial and pharmacologically induced forms of human Parkinson's disease also suggest that mitochondrial dysfunction plays an important role in disease progression. Although many functions have been proposed for α-synuclein, emerging data from human and animal models of Parkinson's disease highlight a role for α-synuclein in the control of neuronal mitochondrial dynamics. Here, we review the α-synuclein structural, biophysical and biochemical properties that influence relevant mitochondrial dynamic processes such as fusion-fission, transport and clearance. Drawing on current evidence, we propose that α-synuclein contributes to the mitochondrial defects that are associated with the pathology of this common and progressive neurodegenerative disease.
NFκB signaling in alveolar rhabdomyosarcoma
Authors: Cleary Megan M. , Mansoor Atiya , Settelmeyer Teagan , Ijiri Yuichi , Ladner Katherine J. , Svalina Matthew N. , Rubin Brian P. , Guttridge Denis C. , Keller Charles
Published: September 2017

Alveolar rhabdomyosarcoma (aRMS) is a pediatric soft tissue cancer commonly associated with a chromosomal translocation that leads to the expression of a Pax3:Foxo1 or Pax7:Foxo1 fusion protein, the developmental underpinnings of which may give clues to its therapeutic approaches. In aRMS, the NFκB–YY1–miR-29 regulatory circuit is dysregulated, resulting in repression of miR-29 and loss of the associated tumor suppressor activity. To further elucidate the role of NFκB in aRMS, we first tested 55 unique sarcoma cell lines and primary cell cultures in a large-scale chemical screen targeting diverse molecular pathways. We found that pharmacological inhibition of NFκB activity resulted in decreased cell proliferation of many of the aRMS tumor cultures. Surprisingly, mice that were orthotopically allografted with aRMS tumor cells exhibited no difference in tumor growth when administered an NFκB inhibitor, compared to control. Furthermore, inhibition of NFκB by genetically ablating its activating kinase inhibitor, IKKβ, by conditional deletion in a mouse model harboring the Pax3:Foxo1 chimeric oncogene failed to abrogate spontaneous tumor growth. Genetically engineered mice with conditionally deleted IKKβ exhibited a paradoxical decrease in tumor latency compared with those with active NFκB. However, using a synthetic-lethal approach, primary cell cultures derived from tumors with inactivated NFκB showed sensitivity to the BCL-2 inhibitor navitoclax. When used in combination with an NFκB inhibitor, navitoclax was synergistic in decreasing the growth of both human and IKKβ wild-type mouse aRMS cells, indicating that inactivation of NFκB alone may not be sufficient for reducing tumor growth, but, when combined with another targeted therapeutic, may be clinically beneficial.
Plausible link between circabidian activity rhythms and circadian-clock systems in the large black chaferHolotrichia parallela
Authors: Kawasaki Yuta , Nishimura Hitoshi , Shiga Sakiko
Published: September 2017

Two-day rhythms referred to as circabidian rhythms were reported in humans and mosquitos. However, these rhythms only appear under constant conditions, and functional mechanisms of two-day rhythms have not been known. Here, we report clear circabidian rhythms of large black chafers (Holotrichia parallela, Coleoptera: Scarabaeidae) in both the laboratory and field. Under 12 h light and 12 h dark conditions (LD 12:12) at 25°C, H. parallela appeared on the ground at the beginning of the dark phase every two days. Under constant darkness, H. parallela exhibited free-running with a period of 47.9 ± 0.3 h, suggesting the existence of a clear circabidian rhythm entrained to two LD 12:12 cycles. Phase responses of the circabidian rhythm to light pulses occurred under constant darkness in a phase dependent manner. Phase responses suggest that there are two circadian cycles, each consisted of a less responsive and high responsive period, in a circabidian oscillation, and the circabidian rhythm is driven by the circadian clock. A mark and recapture study showed that beetles repeatedly appeared on the same tree approximately every two days. However, the periodicity was not as rigid as that observed under laboratory conditions in that individuals often switched appearance days. For instance, large precipitation made the two-day rhythm shift the phase by a half cycle of the rhythm at a time. Here, we propose a novel function of the circadian clock characterized by the release of an output signal every two cycles to produce the two-day rhythm.
A Demonstration of Physician-Generated Health Care Costs in an Initial Orthopaedic Visit
Authors: Schwartz Andrew , Levin Paul , Lovy Andrew , Koenig Jonathan
Published: September 2017

Background: The cost of health care in the United States continues to grow faster than any other sector of the economy. A small portion of the health care costs is attributed to physician reimbursement, but orthopaedic surgeons have an abundance of costly diagnostic and therapeutic modalities for patient care. Providers must be aware of the health care costs they generate in their practice in order to become stewards of cost control. Identifying the costs associated with an ambulatory orthopaedic practice is an important foundation in understanding and controlling the costs that the practice generates.

Questions: What is the average cost of an initial encounter with an orthopaedic surgeon? What are the most costly elements in a management plan? How can we financially optimize resource utilization?

Methods: We conducted a retrospective review of the records of 23 orthopaedic surgeons that span the main orthopaedic subspecialties at an urban academic medical center. All physician-generated orders were obtained and valuated by their cost to the institution’s health care management organization.

Results: A total patient of 822 encounters were reviewed with a total cost of $403,235 (an average of $490 per patient).

The most prevalent order was an x-ray (68.1% of patients). The majority of the financial burden was from physical therapy prescriptions (43.1% of total costs). The most expensive diagnostic modalities were advanced imaging studies, particularly magnetic resonance imaging and computed tomography (20.8% of costs).

Conclusion: This health care burden exposé is not designed to discourage technology utilization. The authors aim to encourage stewardship through judicious use of diagnostic and therapeutic modalities. Most common musculoskeletal conditions presenting for evaluation can be appropriately diagnosed with a thorough history and physical examination followed by initial non-operative management. Diagnostic workups are only necessary during an initial visit when the initial evaluation suggests life or limb threatening conditions that need to be identified in an expeditious fashion. Diagnostic imaging may become necessary during future visits if the patient has not responded to the initial management and the patient is ready to undergo a surgical intervention based on the imaging. Obtaining imaging to identify a surgical lesion is an unnecessary expense if the patient is not ready to undergo surgery. Understanding the cost of clinical decisions can promote adherence to evidence-based diagnostic indications to more efficiently use health care funds.
The lectotypification of two names referred by Linnaeus to the genus Illecebrum (Caryophyllales): Illecebrum benghalense and Iresine javanica , with comments on Aerva tomentosa
Authors: Iamonico Duilio , Friis Ib
Published: September 2017

Linnaeus had a broad concept of Illecebrum and, based on the current circumscription wherein the genus is considered monotypic, only one out of the seventeen names Linnaeus treated in combination with Illecebrum – I. verticillatum – remains in the genus. The other sixteen names are now referred to other genera of both Caryophyllaceae (Chaetonychia , Paronychia , Polycarpon ), and Amaranthaceae (Achyranthes ,Aerva ,Althernanthera ,Blutaparon ,Nothosaerva ). Two of the species referred to Illecebrum by Linnaeus have remained to be investigated from a nomenclatural point of view, I. bengalense and I. javanicum. Illecebrum bengalense is here lectotypified with a specimen preserved at LINN and is placed in synonymy withNothosaerva brachiata. Illecebrum javanicum , based onIresine javanica , is lectotypified with a Burman illustration. The name Aerva tomentosa is placed in synonymy ofIresine javanica.
Evidence generation for wound care dressing selection: reviewing the issues
Authors: Pagnamenta F.
Published: September 2017

In the UK, dressings are categorised as medical devices and manufacturers only have to provide limited evidence of effectiveness before dressings are used in clinical practice. Therefore, evidence based on clinical trial methods is scant. As a direct result, governing bodies in the UK are now recommending that decisions to select one dressing over another could mainly be made on price. Placed within the movement critiquing evidence-based practice (EBP), this paper summarises the main issues surrounding the generation of evidence in selecting dressings for wound care, which is immersed in a context that lacks resources, legislative clarity and freedom to choose methodological alternatives. Dressings are therapeutic medical devices rather than consumables and any rationalisation based on costs may have far-reaching implications for wound care clinicians through purchasing decisions and thus may limit their ability to manage wounds effectively.
Potential correlation of wound bed score and biomarkers in chronic lower leg wounds: an exploratory study
Authors: Dini V. , Papadia F. , Francesco F. Di , Salvo P. , Paolicchi A. , Janowska A. , Chiricozzi A. , Oranges T.
Published: September 2017

Objective:

The wound bed score is a validated tool to monitor wound healing in chronic wounds, and depends on visual examination by trained personnel. This study describes the feasibility of adding some biochemical and immunohistochemical parameters to increase the objectivity and specificity of the wound bed score

Method:

Patients with chronic wounds on the lower leg with different durations were enrolled to assess the correlation between the wound bed score and specific wound-related biomarkers, namely MMP-9, MMP-2, NGAL, albumin, integrin α2/β1, and other histochemical (CD68, PK1, CD32, fractalkine, periostin) and immunocytochemical markers from biopsies and smears taken from wound edges and bed.

Results:

The study examined samples from 10 patients. Patients with an unfavourable wound bed score had a low expression of periostin and fractalkine in the wound bed tissue. CD68 PK1 showed a low or negative expression in the majority of the samples. Patients negative for CD68 PK1 were also negative for CD32. Principal component analysis revealed that the albumin level and the amount of proteins were associated with a high wound bed score. Two different subsets of patients could be discriminated either by integrin α2/β1 and albumin percentages or the MMP-9 and MMP-2 activities

Conclusion:

These preliminary results pave the way towards an improved wound status diagnosis and an advanced quality of wound care and management. These findings need confirming with a large number of patients and at different time points.
Customer engagement in UK water regulation: towards a collaborative regulatory state?
Authors: Heims Eva , Lodge Martin
Published: September 2017

Little is known about how processes of ‘expert’ control interact with or move towards collaborative models of regulation. This paper focuses on a critical example of such an apparent shift: customer engagement in price-setting in water regulation in Scotland and England/Wales. By drawing on original interview and documentary analysis, the paper demonstrates a neglected rationale for and usage of ‘collaborative regulation’: regulators introduced customer engagement to incentivise regulated firms into further efficiencies. This points towards an increasing hybridisation of the contemporary regulatory state, in which collaborative regulatory processes are used to advance ‘econocratic’ objectives of expert regulators.
IMPLEMENTASI KEBIJAKAN KESEHATAN REPRODUKSI DI INDONESIA: SEBELUM DAN SESUDAH REFORMASI
Authors: Fatoni Zainal , Astuti Yuly , Situmorang Augustina , NFN Widayatun , Purwaningsih Sri Sunarti
Published: September 2017

Policy on reproductive health is one of the essential determinant to address the goals of population and health development in Indonesia. Maternal Mortality Ratio (MMR), teenage marriage, and Total Fertility Rate (TFR) are among the indicators that show the important role of reproductive health policy. This article discusses the progress of reproductive health policy implementation in Indonesia and its implication to early marriage, TFR, and MMR. Data used in this paper are mainly derived through desk studies from previous research conducted by the Research Center for Population Indonesian Institute of Sciences. The studies consist of reproductive health policy and regional autonomy (2000-2005), BKKBNs decentralization (2005), HIV/AIDS in border areas (2006-2009), and the implementation of integrated reproductive health services in primary health care (2007). Desk reviews are also used to analyze current studies from LIPI that are related to these issues.LIPIs [AD1]studies showed that there is a gap between the implementation of reproductive health policy at the global and national level with the district level. The implementation of reproductive health services are not yet integrated as it is less popular than adolescent reproductive health policy. Policy priorities for relevant stakeholders have not been implemented synergically. The implementation of decentralization policy in early 2000s created various commitments from the local government in prioritizing reproductive health programs. BKKBNs decentralization, for example, has affected not only the structure of its institution at district level, but also the function of the family planning facilitator at village level. Meanwhile, pilot project implementation on the integrated essential reproductive health services in primary health cares that has significant contribution also faced uncertainty in terms of its continuation. Hence, this article suggests the importance of synergizing reproductive health policy at the global, national, and district level to meet the appropriate situation and needs at the local context. Otherwise, teenage marriage, TFR, and MMR as well as other population issues will be further overlooked.[AD1]Disini tidak menyebutkan P2 Kependudukan
PARTISIPASI KELUARGA ANGGOTA BINA KELUARGA BALITA (BKB) DALAM PENGASUHAN DAN TUMBUH KEMBANG ANAK USIA 0-6 TAHUN
Authors: Oktriyanto NFN
Published: September 2017

The age of 0-6 years is the most critical period in determining the quality of life in the future. By participating in the activities of Bina Keluarga Balita (BKB), families are expected to be  able to provide the best care for the growth and development of the children. The purpose of this analysis is to determine: 1) The differences between  families member of BKB and families are not member BKB on their participation in growth and development of children age 0- 6 years.  2) Factors that affect the family's participation in growth and development of children age 0- 6 years.  This analysis used secondary data from Performance Indicator Survey of The National Medium Term Development Plan in Population and Family Planning Proram Year 2015. The survey was conducted in 34 provinces throughout Indonesia. Respondents used are families with children age  0-6 years, with the total number of respondents 16 172 families. The results showed that the family’s participation in the growth and development of children age  0-6 years is better in the family members of BKB than families who do not participate in BKB from all aspects (physical, mental and social). The results of logistic regression analysis showed that the level of family welfare, maternal age, maternal education, maternal work status, family who have children aged 0-6 years, and family participation in BKB group has significant effect on family participation in growth and development of children age 0- 6 years
Auto-join
Authors: Zhu Erkang , He Yeye , Chaudhuri Surajit
Published: September 2017

Traditional equi-join relies solely on string equality comparisons to perform joins. However, in scenarios such as ad-hoc data analysis in spreadsheets, users increasingly need to join tables whose join-columns are from the same semantic domain but use different textual representations, for which transformations are needed before equi-join can be performed. We developed Auto-Join, a system that can automatically search over a rich space of operators to compose a transformation program, whose execution makes input tables equi-join-able. We developed an optimal sampling strategy that allows Auto-Join to scale to large datasets efficiently, while ensuring joins succeed with high probability. Our evaluation using real test cases collected from both public web tables and proprietary enterprise tables shows that the proposed system performs the desired transformation joins efficiently and with high quality.
ASAP
Authors: Rong Kexin , Bailis Peter
Published: September 2017

Time series visualization of streaming telemetry (i.e., charting of key metrics such as server load over time) is increasingly prevalent in modern data platforms and applications. However, many existing systems simply plot the raw data streams as they arrive, often obscuring large-scale trends due to small-scale noise. We propose an alternative: to better prioritize end users' attention, smooth time series visualizations as much as possible to remove noise, while retaining large-scale structure to highlight significant deviations. We develop a new analytics operator called ASAP that automatically smooths streaming time series by adaptively optimizing the trade-off between noise reduction (i.e., variance) and trend retention (i.e., kurtosis). We introduce metrics to quantitatively assess the quality of smoothed plots and provide an efficient search strategy for optimizing these metrics that combines techniques from stream processing, user interface design, and signal processing via autocorrelation-based pruning, pixel-aware preaggregation, and on-demand refresh. We demonstrate that ASAP can improve users' accuracy in identifying long-term deviations in time series by up to 38.4% while reducing response times by up to 44.3%. Moreover, ASAP delivers these results several orders of magnitude faster than alternative search strategies.
Pyramid sketch
Authors: Yang Tong , Zhou Yang , Jin Hao , Chen Shigang , Li Xiaoming
Published: September 2017

Sketch is a probabilistic data structure, and is used to store and query the frequency of any item in a given multiset. Due to its high memory efficiency, it has been applied to various fields in computer science, such as stream database, network traffic measurement,
etc.
The key metrics of sketches for data streams are accuracy, speed, and memory usage. Various sketches have been proposed, but they cannot achieve both high accuracy and high speed using limited memory, especially for skewed datasets. To address this issue, we propose a sketch framework, the Pyramid sketch, which can significantly improve accuracy as well as update and query speed. To verify the effectiveness and efficiency of our framework, we applied our framework to four typical sketches. Extensive experimental results show that the accuracy is improved up to 3.50 times, while the speed is improved up to 2.10 times. We have released our source codes at Github [1].
CleanM
Authors: Giannakopoulou Stella , Karpathiotakis Manos , Gaidioz Benjamin , Ailamaki Anastasia
Published: September 2017

Data cleaning has become an indispensable part of data analysis due to the increasing amount of dirty data. Data scientists spend most of their time preparing dirty data before it can be used for data analysis. At the same time, the existing tools that attempt to automate the data cleaning procedure typically focus on a specific use case and operation. Still, even such specialized tools exhibit long running times or fail to process large datasets. Therefore, from a user's perspective, one is forced to use a different, potentially inefficient tool for each category of errors.

This paper addresses the coverage and efficiency problems of data cleaning. It introduces CleanM (
pronounced clean'em
), a language which can express multiple types of cleaning operations. CleanM goes through a three-level translation process for optimization purposes; a different family of optimizations is applied in each abstraction level. Thus, CleanM can express complex data cleaning tasks, optimize them in a unified way, and deploy them in a scaleout fashion. We validate the applicability of CleanM by using it on top of CleanDB, a newly designed and implemented framework which can query heterogeneous data. When compared to existing data cleaning solutions, CleanDB a) covers more data corruption cases, b) scales better, and can handle cases for which its competitors are unable to terminate, and c) uses a single interface for querying and for data cleaning.
Parallel replication across formats in SAP HANA for scaling out mixed OLTP/OLAP workloads
Authors: Lee Juchang , Moon SeungHyun , Kim Kyu Hwan , Kim Deok Hoe , Cha Sang Kyun , Han Wook-Shin
Published: September 2017

Modern in-memory database systems are facing the need of efficiently supporting mixed workloads of OLTP and OLAP. A conventional approach to this requirement is to rely on ETL-style, application-driven data replication between two very different OLTP and OLAP systems, sacrificing real-time reporting on operational data. An alternative approach is to run OLTP and OLAP workloads in a single machine, which eventually limits the maximum scalability of OLAP query performance. In order to tackle this challenging problem, we propose a novel database replication architecture called Asynchronous Parallel Table Replication (ATR). ATR supports OLTP workloads in one primary machine, while it supports heavy OLAP workloads in replicas. Here, row-store formats can be used for OLTP transactions at the primary, while column-store formats are used for OLAP analytical queries at the replicas. ATR is designed to support elastic scalability of OLAP query performance while it minimizes the overhead for transaction processing at the primary and minimizes CPU consumption for replayed transactions at the replicas. ATR employs a novel optimistic lock-free parallel log replay scheme which exploits characteristics of multi-version concurrency control (MVCC) in order to enable real-time reporting by minimizing the propagation delay between the primary and replicas. Through extensive experiments with a concrete implementation available in a commercial database system, we demonstrate that ATR achieves sub-second visibility delay even for update-intensive workloads, providing scalable OLAP performance without notable overhead to the primary.
Samza
Authors: Noghabi Shadi A. , Paramasivam Kartik , Pan Yi , Ramesh Navina , Bringhurst Jon , Gupta Indranil , Campbell Roy H.
Published: September 2017

Distributed stream processing systems need to support
stateful processing, recover quickly from failures
to resume such processing, and
reprocess
an entire data stream quickly. We present Apache Samza, a distributed system for stateful and fault-tolerant stream processing. Samza utilizes a partitioned local state along with a low-overhead background changelog mechanism, allowing it to scale to massive state sizes (hundreds of TB) per application. Recovery from failures is sped up by re-scheduling based on Host Affinity. In addition to processing infinite streams of events, Samza supports processing a finite dataset as a stream, from either a streaming source (e.g., Kafka), a database snapshot (e.g., Databus), or a file system (e.g. HDFS), without having to change the application code (unlike the popular Lambda-based architectures which necessitate maintenance of separate code bases for batch and stream path processing).

Samza is currently in use at LinkedIn by hundreds of production applications with more than 10, 000 containers. Samza is an open-source Apache project adopted by many top-tier companies (e.g., LinkedIn, Uber, Netflix, TripAdvisor, etc.). Our experiments show that Samza: a) handles state efficiently, improving latency and throughput by more than 100X compared to using a remote storage; b) provides recovery time independent of state size; c) scales performance linearly with number of containers; and d) supports reprocessing of the data stream quickly and with minimal interference on real-time traffic.
noWorkflow
Authors: Pimentel João Felipe , Murta Leonardo , Braganholo Vanessa , Freire Juliana
Published: September 2017

We present noWorkflow, an open-source tool that systematically and transparently collects provenance from Python scripts, including data about the script execution and how the script evolves over time. During the demo, we will show how noWorkflow collects and manages provenance, as well as how it supports the analysis of computational experiments. We will also encourage attendees to use noWorkflow for their own scripts.