bluuebunny/crossref_metadata_2025 huggingface dataset:
Functional and morphological maturation of the full-sized and mini-pig corpus luteum by programmed cell death mechanism
Authors: Lee Ji-Hye , Kim Sang-Hwan
Published: April 2023

Introduction

The formation and function of the corpus luteum (CL) increase the likelihood of pregnancy and efficiently manage implantation. Apoptosis must occur at an appropriate time in the formation of the CL. This also affects its function. However, it is still unclear if the type of apoptosis affects the function.

Material and Methods

We conducted morphological analysis of the CL collected on day 15 between the middle and late oestrous phases of Yorkshire pigs and mini-pigs, and measured the difference in hormone expression and apoptosis using an immunoassay method and messenger RNA level.

Results

The CL cells were more uniform in the Yorkshire pigs than in the mini-pigs, and the composition of the CL was also fuller. The expression of luteinising hormone was higher in the Yorkshire pigs. Apoptosis and the rate of action of matrix metalloproteinases (MMPs) were different between the two pig types. Expression of MMPs was higher in the Yorkshire pigs than in the mini-pigs. However, the expression of caspase 3 and 20alpha-hydroxysteroid dehydrogenase, a progesterone inhibitor, was potentiated in the mini-pigs.

Conclusion

Autophagy throughout the CL was more extensive in the Yorkshire pigs than in the mini-pigs, suggesting that autophagy and cell reorganisation by MMPs were highly correlated. The occurrence of autophagy in the formation and function of the CL may affect the action of hormones and expression of cell reconstitution factors.
Perception of plastic surgery among medical students
Authors: Shash Hani , Marzouq Sawsan , Alghamdi Abdulrahman , Shash Hayam , Quren Ahmed
Published: April 2023

Background: The misconception of plastic surgery as a purely esthetic specialty is common among medical students, interns, and the general population. Therefore, this questionnaire-based cross-sectional study was aimed at assessing the perception of plastic surgery among medical students and interns in Saudi Arabia and Canada. This study aims to elicit a thorough grasp of the numerous pathologies addressed by plastic surgeons from medical students and interns.
Methods: A cross-sectional study was conducted in February 2020, targeting medical students and interns in Saudi Arabia: Imam Abdulrahman Bin Faisal University, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz University, and Canada (McGill). Paper and online-based questionnaires were distributed among participants, featuring 16 medical scenarios requiring participants to select the specialty that best fit each case. Nine of these scenarios were handled mainly by plastic surgeons.
Results: All-inclusive, 729 students and interns answered the questionnaire. The fact that just three of the nine plastic surgery scenarios were accurately selected by the participants suggests that most medical students and interns need to understand the range of services that plastic surgeons can provide.
Conclusion: This study concluded that there is an overlap between different surgical specialties in the field. Thus training initiatives and increased exposure to plastic surgery subspecialties throughout medical school and educational programs are needed to establish boundaries and dispel misconceptions about this specialty.
Developing an Augmented Reality Application as Instruction Media to Help in Learning the Solar System
Authors: Sholeh Muhammad , Fatkhiyah Erfanti , Aprianto Heru
Published: April 2023

This study aimed to develop an application to help in learning the solar system using Augmented Reality (AR) technology. In an era where technology is very developed, learning about the solar system can be made more interactive by providing 3D illustrations to the students. One of the technologies that can be applied to support the development of educational applications to help in learning about the solar system is AR technology. It can create 3D illustrations. The study is the Research and Development (R&D). The research produced an AR-based solar system introduction application. This application can be used as a learning media for students. The developed AR application was tested using alpha and beta testing. The alpha testing was the marker accuracy testing and black-box testing, while the beta testing was done by distributing questionnaires to 30 respondents and then doing validity and reliability test. This study produced an AR application to help in learning the solar system. The black-box testing showed that the AR application generally was functioning well. The marker accuracy testing showed that the AR camera succeeded in scanning markers up to 25% of the marker area. The data obtained from distributing questionnaires were processed to know the validity in terms of attractiveness and effectiveness, and the results showed the data was valid. Moreover, the reliability testing was carried out with Cronbach's alpha, and the result was 0.771 for the attractiveness aspect and 0.742 for the effectiveness aspect. These values mean that most beta testers agree that the AR application was attractive and effective.
Importancia del fortalecimiento de la cooperación militar para Colombia frente a amenazas a la soberanía e integridad territorial: el caso del litigio de las aguas territoriales con Nicaragua
Authors: Muñoz Gómez José Efrén , Acosta Guzmán Henry Mauricio , Pinzón Arana Federico
Published: April 2023

Más allá de las implicaciones jurídicas a nivel internacional de aceptar o no el Fallo de la Corte Internacional de Justicia (CIJ) de La Haya del año 2012 sobre el litigio de las aguas circundantes del archipiélago de San Andrés y Providencia, derecho histórico y soberano de la República de Colombia, la pretensión de Nicaragua tiene implicaciones directas sobre la estabilidad de la región, pues las argucias territoriales nicaragüenses sobre aguas nacionales no solo representan un acto de provocación sino una amenaza a la integridad territorial de Colombia. Ante el escenario internacional, se presenta el siguiente interrogante de análisis ¿Cuál es la importancia del fortalecimiento de la cooperación militar para Colombia frente a los escenarios internacionales?Al respecto, el objetivo del presente documento consiste en analizar la importancia del fortalecimiento de la cooperación militar a Colombia frente a los escenarios internacionales que amenazan la Seguridad y Defensa Nacional, tomando el caso particular de las pretensiones territoriales de Nicaragua. Por lo anterior, el documento se organiza de la siguiente manera: primero, se conceptualiza la noción de cooperación militar; segundo, se describe el escenario internacional que amenaza la Seguridad y Defensa Nacional de Colombia tomando como referente el Fallo de la Corte Internacional de Justicia de La Haya del año 2012; tercero, se describe la importancia del fortalecimiento de la cooperación militar para Colombia; por último, se exponen las conclusiones finales.
La ciberseguridad: análisis político y estratégico
Authors: Saavedra Boris , Parraguez Luisa
Published: April 2023

El ciberespacio es un ambiente complejo y dinámico caracterizado por ser una creación humana sujeta a cambios acelerados, motivados por tres fuerzas que interactúan: la tecnología digital, la globalización y el cambio climático. Este artículo se enfoca en el análisis del ciberespacio desde la óptica de la Seguridad y Defensa a nivel político y estratégico. Se discute el tema de la gobernanza a través de la ciberseguridad adecuada, lo cual constituye el reto más importante y relevante a escala global en este ámbito. El logro de este objetivo requiere del análisis para generar las capacidades estructurales (tecnológicas) así como también de observaciones geopolíticas correspondientes. La complejidad del ciberespacio requiere de una política nacional que defina la capacidad del Estado para desarrollar la tecnología, el recurso humano competente, el financiamiento adecuado y el material necesario. La estrategia deberá explicar el empleo de todos los componentes del ciberespacio y su papel para la materialización de los fines delineados en la política. Finalmente, el ecosistema digital y los actores internacionales ponen en evidencia la compleja dinámica que se presenta actualmente en la interacción entre los Estados.
Hubungan Kejadian Hipertensi dengan Kualitas Hidup Penduduk Lanjut Usia di Wilayah Kerja Puskesmas Rijali Desa Batu Merah Kota Ambon Maluku
Authors: Zawawi Wa Ode Meyutya , Kusadhiani Indrawanti , Siahaya Presli Glovrig
Published: April 2023

Hypertension is a degenerative disease that is often encountered in older people. Health status, such as hypertension, can interfere with the quality of life of the elderly. Objective: To determined the relationship between the incidence of hypertension and the quality of life of the elderly in the working area of the Puskesmas Rijali, Batu Merah Village, Ambon City, in 2022. Methods: This study was an observational analytic study with a cross-sectional design and used a consecutive sampling technique in sampling. Results: This study showed that from 76 samples, as many as 40 people (52.6%) suffered from hypertension and 36 people (47.4%) did not. Eight people (10.5%) had poor quality of life and 68 people (89.5%) had a good quality of life. The bivariate analysis results using Chi-square showed a p-value = 0.715 (p > 0,05). Conclusion: It can be said that there is no significant relationship between the incidence of hypertension and the quality of life of the elderly. Further research is needed regarding other factors that affect the quality of life of the elderly such as subject characteristics, medication adherence, and other chronic diseases, which according to several studies, have significance in determining the quality of life.Keywords: elderly,  hypertension, quality of life
Ivan the Terrible through the eyes of Western diplomats
Authors: Druzhevskii Anton Olegovich
Published: April 2023

In the article, the author analyzes the notes of diplomats who came to Muscovy at the end of the XVІ century and had the opportunity to feel the features of the daily life of the royal court of Dopetrovskaya Rus, entering into direct contact with the highest authorities. Being cunning and observant people, they comprehended the character and motives of Ivan the Terrible's actions, with whom they had a number of private conversations. Conclusions are drawn that reflect the specifics of diplomatic works as a special type of historical source, emphasis is placed on the features of the "Western mentality" of their authors. The author comes to the conclusion that the negative image of Grozny in these works is present largely due to the failure of diplomatic missions. Since the foreign envoys failed to achieve their goals, with bitter resentment they reflect in their writings the customs of a country they do not understand and its sovereign. This serves as an additional reason for classifying these writings as highly subjective.
CONCEPTUAL BASIS OF FINANCIAL CONTROL AT INDUSTRIAL ENTERPRISES
Authors:   Chernihiv Polytechnic National University, Kalchenko Olha
Published: April 2023

Modern industrial enterprises, considered as complex economic systems, decentralize financial management and operate with significant volumes of financial and economic information, which is con-stantly changing and losing its relevance. Based on this, there is an objective need to increase the effi-ciency of financial control and coordination of the activities of various structural divisions of enterprises that correspond to the high dynamism, riskiness and unpredictability of the external and internal envi-ronment. In such conditions, it becomes necessary to implement the achievements of financial control-ling, which coordinates the work of functional services of the enterprise and provides comprehensive information and analytical support to financial management during management decision-making.The purpose of the article is to study the essence of the concept of "financial controlling" and conceptual approaches to its definition, as well as the definition of the main principles of financial controlling at industrial enterprises.The article formulates the meaning of financial controlling for industrial enterprises in modern conditions, conducts an analysis of the essenceof the economic category "financial controlling" and highlights two approaches to its definition: institutional and functional, and provides their characteris-tics. Within the framework of the functional approach, four concepts are analyzed: the concept ofthe control function, the concept of the coordination function, the concept of the information function and the concept based on management. The main goal and priority tasks of financial controlling at industrial enterprises are formulated; the main principles of financial controlling for industrial enterprises are researched and formulated: target orientation, systematicity, responsibility, independence, complexity, automation, confidentiality, internal audit, objectivity, economy, timeliness.
Wkład ks. profesora Jana Chwałka w organologię i sztukę budowy organów
Authors: Szymanowicz Maria
Published: April 2023

Ks. Jan Chwałek urodził się 7 stycznia 1930 r. w Woli Baranowskiej, zmarł 30 listopada 2018 r. w Babulach i został pochowany na cmentarzu parafialnym w rodzinnej miejscowości.W latach 1961–2005 był wykładowcą w Instytucie Muzykologii Katolickiego Uniwersytetu Lubelskiego Jana Pawła II, kierownikiem jedynej w Polsce Katedry Instrumentologii. Na początku swej naukowej drogi zajmował się chorałem gregoriańskim, a po uzyskaniu samodzielności – problematyką organologiczną.Na szczególną uwagę zasługuje książka Budowa organów, jedyne takie dzieło w literaturze polskiej. Zawiera ona opis mechanizmów i głosów organowych, a poszczególne zagadnienia ilustrowane są rysunkami technicznymi. Ks. Chwałek wypracował metodę badań struktury brzmieniowej organów przy pomocy skali poziomej i pionowej, szczegółowo opisał trzy systemy strojenia instrumentów klawiszowych.Był także organmistrzem, zbudował dziewięć instrumentów. W niektórych z nich zastosował nietypowe rozwiązania konstrukcyjne. Zaprojektował kilkadziesiąt nowych organów. Uczestniczył w pracach konserwatorskich zabytkowych instrumentów w Kazimierzu Dolnym, Olkuszu i Jędrzejowie. Wykonał kilkadziesiąt konserwacji organów, głównie w diecezji sandomierskiej.
Reforma liturgiczna jest nieodwracalna
Authors: Nowakowski Przemysław
Published: April 2023

Artykuł jest głosem w dyskusji wokół soborowej reformy liturgii, która jest dziś nierzadko krytykowana, a nawet kontestowana, przez zwolenników starej formy obrządku rzymskiego. Przypomniana zostaje pokrótce teologia liturgii wypracowana przez Sobór Watykański II-gi. Jej właściwe zrozumienie i pogłębienie może, według autora, zapewnić coraz lepszą realizację odnowy liturgii, która w praktyce natrafia na różne przeszkody i trudności. Nie przekreślają one jednak słuszności samej reformy, która niezmiennie pozytywnie oceniana jest przez ostatnich papieży. Całkowite odrzucenie reformy liturgicznej oznaczałoby brak akceptacji soborowej eklezjologii. Istnienie dwóch form obrządku rzymskiego w jednym Kościele możliwe jest tylko pod warunkiem wzajemnego poszanowania i uznania oraz przyjęcia całości nauczania Soboru Watykańskiego II-go (także w odniesieniu do liturgii), co obowiązuje wszystkich katolików.
Reforma liturgiczna jest nieodwracalna.
Authors: Semenova Viktoriya
Published: April 2023

Wobec rosnącej popularności ekstraordynarnej formy obrządku rzymskiego i przeciwstawiania jej nowej formie, autor postanowił podzielić się kilkoma refleksjami z pozycji badacza liturgii i prawa. Artykuł dotyczy niektórych tendencji w obszarze badania liturgii Kościoła Rzymskokatolickiego, zwłaszcza braku zainteresowania aspektem prawnym w jej analizie, co powoduje pewne problemy metodologiczne. Autor uwzględnia szczególnie problem istnienia dwóch form Mszy św. w ramach jednego rytu (obrządku) Kościoła Rzymskokatolickiego. W celu jego zbadania proponuje hermeneutykę romanistyczną, pozwalającą w harmonijnej współpracy z teologią i filozofią, uniknąć błędów metodologicznych popełnianych w odczytaniu znaków liturgicznych, co jest często przyczyną sztucznego konfliktu między zwolennikami nowego i starego ordo.
Prepublication Publications
Authors: Crespi Gregory Scott
Published: April 2023

Many law professors now post essentially complete drafts of their articles on SSRN and/or on university-sponsored working paper websites prior to submitting those articles for journal review and possible publication. This “prepublication publication,” so to speak, is useful for both authors and their readers, but it raises some self-plagiarism issues. There does not yet appear to be a broad consensus among journal editors on how those issues should be addressed. I argue that this increasingly common practice of SSRN and working paper prepublication of articles prior to their submission for journal review should be recognized as entirely appropriate, particularly if this prior publication is disclosed in the journal submission or is otherwise called to the attention of the journal editors. I also argue that in light of this practice law journals should rather substantially change the way that they operate. They should move to a wholly online format and provide only article abstracts and website links for the articles that they “accept,” rather than editing the articles and then providing their readers with full article texts.
Infecção do Trato Urinário associado ao Cateterismo Vesical em pacientes críticos: evidências para o cuidado de enfermagem
Authors: Santos Caroline Macedo Calegario dos , Pereira Daniela Tatiana da Cunha , Almeida Daniella Valença Daher de
Published: April 2023

Objetivo: Identificar na literatura medidas de prevenção da ocorrência de Infecção de Trato Urinário associado ao Cateterismo Vesical (ITU-AC). Métodos: Revisão integrativa cuja busca ocorreu nas bases de dados Literatura Latino Americana e do Caribe em Ciências da Saúde, Medical Literature Analysis and Retrievel System Online e na Base de Dados Bibliográficas Especializada na Área de Enfermagem. Os critérios de inclusão foram artigos publicados nos últimos 5 anos, nas línguas portuguesa, inglesa e espanhola, com a temática da infecção urinária relacionada ao cateterismo vesical em pacientes hospitalizados e à atuação da equipe de enfermagem. Foram excluídos estudos de revisões de literatura, artigos que abordavam microrganismos ou terapias medicamentosas e outros tipos de dispositivos urinários. Resultados: Boas práticas na manutenção do cateter são indispensáveis para evitar a ITU-AC, destacam-se à higienização das mãos e antissepsia da região perineal, manutenção da bolsa coletora abaixo do nível da bexiga, devendo ser esvaziada quando atingir dois terços da sua capacidade e sistema sempre fechado. Considerações finais: A equipe de enfermagem tem uma responsabilidade considerável na prevenção da ITU-AC, dessa forma, é necessário que tenham conhecimento dos fatores de risco e complicações que estão associados e prestem assistência buscando prevenir o desenvolvimento desse problema.
Morphometry of the lower lumbar spinal canal among a sample of the Saudi population: Are we at risk?
Authors: Alghamdi Khalid , Omer Ibrahim
Published: April 2023

Objectives:

Lumbar disk bulge is a common cause of lower back pain. A high percentage of patients improve with conservative management, but unfortunately, some do not. We postulate that an anatomically narrowed lumbar spinal canal might contribute to this variation in response to conservative management. One of the major causes of spinal stenosis is idiopathic congenital-developmental stenosis, and here, we aimed to observe if this non-modifiable risk factor is present among the Saudi population, by analyzing the lower lumbar canal dimensions in computed tomography (CT) scan axial cuts, which might be later a reference and guide in clinical practice.

Methods:

This retrospective descriptive study included 279 patients aged 20–40years old. We included those who underwent diagnostic CT abdomen and CT lumbar spine with no evidence of lumbar spinal disease or fracture at the level where measures were taken from the axial cuts. Furthermore, exclusion criteria included gross spinal pathologies such as fractures, tumors, deformities, major chronic systemic diseases, congenital anomalies (dwarfism), and metallic artifacts.

Results:

Of the 279 patients, 137 (49%) were male and 142 (51%) were female. Different measurements were taken from the CT scan of axial cuts of the lower lumbar canal (L3, L4, and L5). The pattern of segmental variation of the lower lumbar vertebral canal was found to be like other populations. In contrast, the mean lower lumbar vertebral canal diameters were characteristically different from the other population (non-compensating).

Conclusion:

In the Saudi population, anterior-posterior and interpedicular diameters were narrowed (non-compensating). We found a high prevalence (32%) of trefoil configuration in the Saudi population.
Üniversite öğrencilerinin girişimci kişilik ve eğilimini etkileyen "girişimcilik eğitimi" yeterli mi?
Authors: TAŞDOĞAN Celal , ŞEKEROĞLU Sinan , ZENGİN Bekir
Published: April 2023

Girişimcilik, mal veya hizmet üretimi için gerekli olan faktörlerin ekonomi için yeni fırsatların ve yeni değerlerin ortaya çıkarılmaya çalışıldığı organizasyondur. Daha çok genç beyinlerin enerjileri ve fikirleri sayesinde ortaya çıkan girişimciliğin, gelişmesinde üniversiteler önemli bir rol oynamaktadır. BuçalışmaAnkara Hacı Bayram Veli Üniversitesinde öğrenim gören öğrencilerin girişimcilik eğiliminive kişilikleriniölçmek,girişimcilik kişiliği ve eğilimiarasındaki farkların/benzerliklerin demografik veriler ile analiz edilmesini amaçlamıştır. Elde edilen bulgulara göre faktörlerin değişkenliklerine göre girişimcilik kişiliği ve girişimcilik eğilimine sahip farklı grupların değişkenlik gösterdiğitespit edilmiştir. Girişimcilik eğitiminin girişimcilik eğilimi üzerinde önemli etkileri olmasına rağmen öğrencilerin yeterli düzeyde girişimcilik dersi almamış olması nedeniyle girişimcilik eğilimlerine eğitimin etkisi konusunda anlamlı bir bulguya ulaşılamamıştır.Analiz sonuçlarındaortaya çıkan bir başka önemli sonuç ise girişimcilik kişiliği ve girişimcilik eğiliminin farklı faktörlerde her zaman paralel olarak ilerlemediğidir. Örneğin cinsiyet faktörü ele alındığında hem girişimcilik kişiliği hem de girişimcilik eğiliminin anlamlıfarklılık gösterdiği görülmüştür. Bu durum bazı fakülte ve yüksekokullar incelendiğinde özellikle sanat ve tasarım fakültesinin ortalamasının diğer bölümlere göre yüksek olduğu görülmüştür. Anne veya baba mesleğinin kişinin girişimcilik kişiliği veya girişimcilik eğilimine etki etmemesi dikkate değer bir diğer sonuçtur.
The United States-The People's Republic of China relations: A systemic level impact analysis
Authors: AKBAL Ozdemir
Published: April 2023

Are the United States (the US)- the People's Republic of China (the PRC) relations inevitably headed for war? The US-the PRC relations constitute one of the most interesting topics in terms of international political studies. Precisely for this reason, the study of political relations between the US and the PRC is of the great importance in terms systemic level of the international political studies. The main purpose of this study is to show that the relations of the US and the PRC, as two influential acting units at the level of systemic international politics, are of competitive cooperation. In this study, Popperian falsification method was used in the context of political, economic and cultural data revealed by bilateral relations. The definition of the inevitably dragged into a war by the US-the PRC with a historicist perspective also brings with it an important problem in terms of international political studies. This point also creates an important opportunity to discuss the explanatory capacity of international political theories. Considering the Structural Realist Theory in the US-the PRC case, it is seen that military, economic and social relations are important in terms of influencing the structure as much as the formation of the structure. The US-the PRC relations, it is seen that a competitive cooperation structure has emerged rather than a process leading to war.
Ukrayna-Rusya krizi ve DTÖ hukuku: Güvenlik istisnalarının yükselişi mi?
Authors: GÖKER Mustafa
Published: April 2023

Ticarive ticaret–dışı çıkarlar ayrımı;uluslararası ilişkilerinköklü tartışmalarından olan siyasal ve siyasal olmayan konular arasındaki önceliğe dair tartışmanınbir yansıması olup, siyaset ve ekonomi arasındaki açığı temsil etmektedir. Bu bağlamda, güvenlik,ticaret–dışı değerlerin en önemlisidir denilebilir. GATT,ticari konuları disipline ederken âkid tarafların ticaret–dışı çıkarlarını da dikkate almıştır. Bu kapsamda, GATT kurallarına aykırı tedbirleri almaya imkân veren çeşitli istisna düzenlemelerine yer verilmiştir. Bunlar arasında ulusal güvenlik istisnaları da yer almaktadır. Güvenlik istisnaları gerek GATT gereksede DTÖ döneminde uzunca bir süre devletlerin başvurmakta ihtiyatla yaklaştıkları bir araçolmuştur. Ancak son yıllarda, uluslararası ilişkilerde artan gerginlik ortamına bağlı olarak,devletleringüvenlik istisnalarınıticaret kısıtlayıcı ulusal önlemlerin meşruiyet dayanağı olarak daha sık öne sürmeye başladıkları gözlenmektedir. Güvenlik istisnaları yakın zamanda iki DTÖ panelinde uygulama alanı bulmuştur. Bunu yenilerinin takip etmesi muhtemeldir. Özellikle, Ukrayna’da 2014 yılında başlayan siyasal gelişmeler ile ABD’de Trump Yönetiminin başta Çin olmak üzere çeşitli ülkelere karşı temelde siyasal gerekçelerle uygulamaya koyduğu ticaret kısıtlayıcı önlemler güvenlik istisnalarını ön plana taşımıştır.Çalışma, DTÖ hukukundaki güvenlik istisnalarının uygulanma koşullarınıve Ukrayna-Rusya Kirizi bağlamında gündeme gelme potansiyelini incelemekte; yöntemolarak, ağırlıkla,yasal metin analizi ve içtihad kararlarına başvurmayı benimsemektedir.
Turizmde tanıtım stratejileri: Fransa ve Türkiye karşılaştırmalı analizi
Authors: ATSIZ Neciphan , GÜZEL Tülay
Published: April 2023

Turizm hareketliliği yıldan yıla giderek artmaktadır. Ülkeler, bölgeler ve destinasyonlar artan imkanlar doğrultusunda rekabet içine girmiş ve daha fazla ziyaretçi için çeşitli yollar denemektedir. Tanıtım faaliyetleri bir ülkenin ya da destinasyonun ziyaretçi sayılarını arttırmasında oldukça önemlidir. Sadece tanıtım faaliyetleri yeterli olmamakta aynı zamanda ülkelerin turizm politikaları hizmet kaynaklarının yaratılması ve olanaklarının arttırılmasını sağlayarak daha çok ziyaretçi gelmesini sağlayabilmektedir. Bu kapsamda dünyada en çok ziyaretçi gelen ülkelerden birisi olan Fransa ile Türkiye’nin turizm tanıtım ve stratejileri doküman analizi tekniğinden yararlanılarak incelenmiştir. Çalışmanın sonucunda Fransa’nın turizmden yüksek gelir elde etmesindeki en onemli nedeninin başarılı bir tanıtım örgütlenme yapısı ve etkin tanıtım stratejileri olduğu ortaya çıkmaktadır. Ek olarak Fransa’nın turizm hizmetlerine Türkiye’ye göre oldukça yüksek pay ayırdığı, turizm organizasyon şeması kapsamında ulusal, bölgesel ve yerel düzeyde her kesimi dahil etmesi ve turistlerin ülkeye daha rahat giriş yapmasını sağlayacak çabalar göstermesi olduğu sonucuna varılmıştır.
İşletmelerin finansal performansı üzerine muhafazakâr muhasebenin etkisi: BİST’te bir araştırma
Authors: TÜRKOĞLU Kader , BEKCİ İsmail
Published: April 2023

Çalışma muhafazakâr muhasebenin işletmelerin finansal performansı üzerine etkisini tespit etmeyi amaçlamaktadır. Çalışmada Borsa İstanbul’da 2010-2020 döneminde kesintisiz olarak işlem gören, konsolide finansal tablo hazırlayan ve düzenli olarak verilerine ulaşılabilen 54 imalat sektörü işletmesi incelenmektedir. Çalışma kapsamında finansal performansı ölçmek için geleneksel finansal performans göstergelerinden aktif kârlılığı, öz kaynak kârlılığı ve hisse başına kâr değişkenleri, piyasa temelli finansal performans göstergelerinden Tobin’s Q oranı, hisse senedi piyasa fiyatı ve piyasa değeri/defter değeri oranı değişkenleri ve modern finansal performans göstergelerinden piyasa katma değeri değişkeni kullanılmıştır. Ayrıca, çalışma kapsamında muhafazakâr muhasebeyi ölçmek için negatif tahakkuklar ölçüm yöntemi, tahakkuklar ve nakit akışlarının asimetrisi ölçüm yöntemi ve kazancın asimetrik zamanlılığı ölçüm yöntemi kullanılmıştır. Çalışmada muhafazakâr muhasebenin işletmelerin finansal performansına etkisinin olup olmadığının tespit edilmesi amacıyla panel veri analiz yöntemi uygulanmıştır. Çalışmada, modeller içinde farklılıklar olmakla birlikte muhafazakâr muhasebenin işletmelerin finansal performansı üzerinde etkili olduğu tespit edilmiş ve bu etkinin pozitif ve negatif biçimde olduğu ortaya çıkarılmıştır.
Türkiye’de doğrudan yabancı sermaye yatırımları, portföy yatırımları, dolar kuru ile BİST100 endeksi arasındaki ilişki üzerine ampirik bir inceleme
Authors: AYDIN Yeter , AKSOY Barış
Published: April 2023

Bu çalışmanın amacı, Türkiye’de doğrudan yabancı sermaye yatırımları ile BİST100 endeksi arasındaki uzun dönem ilişkisini ortaya koymaktır.Doğrudan yabancı sermaye yatırımlarının ekonomi açısından önemi birçok ülke tarafından kabul görmektedir. Gelişmiş ve gelişmekte olan ülkeler doğrudan yabancı sermaye yatırımlarını ülkelerine çekmek için çalışmalar yapmaktadırlar. Bu çalışma ile doğrudan yabancı sermaye yatırımlarının hisse senedi piyasaları açısındanönemini ortaya koymak amaçlanmıştır. Bu amaçla 2005/4-2021/4 dönemleri arasındaki Türkiye Cumhuriyet Merkez Bankası veri tabanında yayınlanan BİST100, doğrudan yabancı sermaye yatırımları, dolar kuru çeyrek dönem verileri kullanılmıştır.Verilerinaynı seviyede durağan olmamalarınedeniyle, farklı seviyelerde durağan olan zaman serileri arasındaki uzun dönem ilişkisini analiz eden ARDL yöntemi kullanılmıştır.ARDL sınır testi bulgularına göre, BİST100 endeksi ile doğrudan yabancı sermaye yatırımları ve dolar kuru arasında uzun dönemli ilişki olduğu ve bu ilişkinin, istatiksel olarak %5anlamlılık düzeyinde, anlamlı olduğu sonucuna ulaşılmıştır. Ancak yabancı portföy yatırımları ile BİST100 endeksi arasındaki ilişki anlamlı çıkmamıştır. Diğer taraftan uzun dönem ilişkisinde herhangi bir nedenden dolayı sapma yaşanırsa, serilerin yaklaşık iki çeyrek dönem sonra, tekrardan uzun dönem ilişkisine döneceği gözlemlenmiştir. Toda -Yamamoto nedensellik analizi sonuçlarına göre, BİST100’ den dolar kuruna ve dolar kurundan doğrudan yabancı sermaye yatırımlarına doğru tek yönlü nedensellik ilişkisi olduğu sonucuna ulaşılmıştır. Diğer değişkenler arasında nedensellik ilişkisi bulunamamıştır. Uzun dönemde doğrudan yabancı sermaye yatırımları BİST100 endeksini pozitif yönde anlamlı olarak etkilemektedir.Literatür çalışmalarında doğrudan yabancı sermaye yatırımlarıile BİST100 endeksi arasında ilişki olmadığı sonucuna ulaşılmıştır (Çetenak ve Doğukanlı, 2006; Boydaş ve Polat, 2018). Ancakbu çalışmadadoğrudan yabancı sermaye yatırımları ile BİST100 endeksi arasında uzun dönemliilişki olduğu ortaya konulmuştur.
Kamu diplomasisi perspektifinden Türkiye – Sahra-Altı Afrika ilişkileri
Authors: DJAMANCA Abdu , ÇAĞLAR Ali
Published: April 2023

Öz

Sahra-Altı Afrika 21. yüzyılda dünya siyaset sahnesinde önemi her geçen gün artan bir aktör olarak dikkat çekmektedir. Kamu diplomasisi ise literatürde özellikle son yıllarda sıkça kullanılan kavramlardan biri olarak ön plana çıkmaktadır. Bu makale, günümüzde dış politikanın önemli araçlarından birini teşkil eden kamu diplomasisi kavramı ışığında, 1998 yılında başlatılan “Afrika Açılım Eylem Planı”ndan günümüze değin Türkiye’nin Sahra-Altı Afrika ülkelerine yönelik yürüttüğü faaliyetlere odaklanmaktadır. Bu kapsamda, küreselleşme ile geleneksel politika yapma ve uygulama pratiklerinin dönüştüğü ve kamuoyunun karar alıcılar üzerindeki etkisinin değiştiği günümüzde, Türkiye’nin Sahra-Altı Afrika’da etkinliğini artırma noktasında attığı adımlar ve bu adımların söz konusu bölge üzerindeki yansımalarının izi sürülmektedir. Bu noktada, makale Türkiye – Sahra-Altı Afrika ilişkilerini siyasetten ekonomiye, kültürden eğitime çok boyutlu biçimde ele almayı hedeflemekte olup, söz konusu incelemenin ana eksenini Türkiye’nin söz konusu bölgeye yönelik kamu diplomasisi faaliyetleri oluşturmaktadır. Makalenin gereksindiği veriler, Türkiye’nin Sahra-Altı Afrika ülkelerine yönelik kamu diplomasisi faaliyetleri özelinde, ikincil veriler - literatürden derlenmiştir. Türkiye’nin özellikle son yıllarda, Sahra-Altı Afrika ülkelerine yönelik, eğitimden insani yardıma, diplomasiden ekonomik iş birliğine çok yoğun bir etkinlik içinde olduğu görülmüştür.

Anahtar Kelimeler: Türkiye, Sahra-Altı Afrika, Kamu Diplomasisi, Yumuşak Güç.
Basics of Alzheimer’s Disease and Dementia
Authors:   Department of Pharmaceutical Analysis, Nirmala College of Pharmacy, India, Swapna Goday , Mahitha M ,   Department of Pharmaceutical Analysis, Nirmala College of Pharmacy, India, Teja Sree P ,   Department of Pharmaceutical Analysis, Nirmala College of Pharmacy, India
Published: April 2023

Alzheimer’s Disease (AD) is a disorder that causes degeneration of the cells in the brain and it is the main cause of dementia, which is characterized by a decline Independence in an individual’s daily activities. AD is considered a multifactorial disease. Two main hypotheses have been proposed as the cause of AD. The cholinergic hypothesis and the amyloid hypothesis. In addition, several risk factors have been implicated in this disease, including aging, genetic factors, head trauma, vascular disease, infections, and environmental factors. Currently, there are only two classes of drugs approved for the treatment of AD, including cholinesterase enzyme inhibitors and N-Methyl-D-Aspartic Acid (NMDA) antagonists, which are not associated with AD symptoms or disease. Prevent. Today, research is focused on understanding the pathology of AD by targeting multiple mechanisms such as alteration of AD course. This review describes the drugs currently available and future theories for the development of new treatments for AD, including Disease-Modifying Therapies (DMTs), chaperones, and natural products.
Spin Polarized Electron Dynamics Enhance Water Splitting Efficiency by Yttrium Iron Garnet Photoanodes: A New Platform for Spin Selective Photocatalysis
Authors: Gajapathy Harshad , Bandaranayake Savini , Hruska Emily , Vadakkayil Aravind , Bloom Brian P. , Londo Stephen , McClellan Jackson , Guo Jason , Russell Daniel , Groot Frank M.F. de , Yang Fengyuan , Waldeck David H. , Schultze Martin , Baker L. Robert
Published: April 2023

This work presents a detailed spectroscopic and kinetic comparison of yttrium iron garnet (Y3Fe5O12, YIG) and hematite (α-Fe2O3) for photocatalytic water splitting. Despite similar electronic structures, YIG significantly outperforms hematite as a water oxidation catalyst, displaying nearly an order of magnitude increase in photocurrent density and a factor of two increase in Faradaic efficiency. Probing the charge and spin dynamics by ultrafast, surface-sensitive XUV spectroscopy reveals that the enhanced performance arises from 1) reduced polaron formation in YIG compared to hematite and 2) an intrinsic spin polarization of catalytic photocurrents in YIG. Linear XUV measurements show a significant reduction in the formation of surface electron polarons in YIG compared to hematite due to site-dependent electron-phonon coupling in YIG leading to spin-polarized currents upon photoexcitation. Direct observation of surface spin accumulation with chemical state resolution at the Fe M2,3 and O L1 edges using XUV magnetic circular dichroism provides a detailed picture of the spin-polarized electron dynamics. Together, these results point to YIG as a new platform for highly efficient, spin-selective photocatalysis.
Theoretical and computational approaches to study crystal nucleation from solution
Authors: Finney Aaron , Salvalaglio Matteo
Published: April 2023

Nucleation is the initial step towards the formation of crystalline materials from solutions. Various factors, such as environmental conditions, additives, and external forces, can influence its outcomes and rates. Indeed, controlling this rate-determining step towards phase separation can affect the material structure and properties, and it is crucial in a range of scientific fields. In this regard, atomistic simulation methods can be exploited to gain insight into nucleation mechanisms - an aspect difficult to ascertain in experiments - and estimate nucleation rates. However, the microscopic nature of simulations affects the phase behaviour of nucleating solutions when compared to macroscopic systems. Additionally, a challenge in modelling nucleation from solution is associated with the inadequacy of standard molecular simulations to access the timescales necessary to observe crystal nucleation due to the inherent rareness of these events. In recent decades, simulation methods have emerged to circumvent length- and timescale limitations. However, which simulation method is most suitable for studying crystal nucleation from solution is not always obvious. This review summarises the recent advances in this field, providing an overview of the typical nucleation mechanisms and the suitability of different simulation methods to study them. By doing so, we aim to provide a deeper understanding of the complexities associated with modelling crystal nucleation from solution and identify areas for further research. Our review targets researchers across various scientific fields, including materials science, chemistry, physics and engineering, and will hopefully contribute to developing new strategies for understanding and controlling nucleation.
Measurement and Analysis of the Impact of Oil Revenues on Imports in Iraq (2004-2021)
Authors: Lazkin Rozan , Hussain Abdul Razzaq
Published: April 2023

This study dealt with the relationship between the imports and the oil revenues in Iraq from 2004 to 2021 by studying and analyzing these variables. The main aims of this study are: identify the nature of the Iraqi imports and the extent of their dependence on oil revenues, explain the shortcomings in the economic policy, especially the commercial, as oil exports constitute 95% of the total Iraqi exports, analyze the growth of the Iraqi imports, as well as oil revenues and their role in the Iraqi economy and measure the impact of oil revenues on the imports. The study hypothesizes that there is a fundamental dependence on oil revenues in funding the imports in the Iraqi economy, which in turn affects the conditions of oil demand in the foreign market, and thus its import capacity corresponds to the trends of its revenues. The results show that during 2004-2021 the imports are clearly consistent with the oil revenues, as the increase or decrease in the revenues affects the imports in the same direction, especially from the consumer side. Besides, there is a financial dominance of oil revenues over the Iraqi economy as they constitute 95% of the public revenues. They are considered the main factor for financing the Iraqi federal general budget resulting in a unilateral economy. Additionally, there is a lack of a clear-cut trade policy and dominance of the consumer pattern. The Iraqi economy is unilateral in terms of export and diversified in imports. Nowadays, the Iraqi market imports most of its needs from abroad and this affected the local production and removed much of it from the circle of competition.
BAZ2A-RNA mediated association with TOP2A and KDM1A represses genes implicated in prostate cancer
Authors: Roganowicz Marcin , Bär Dominik , Bersaglieri Cristiana , Aprigliano Rossana , Santoro Raffaella
Published: April 2023

BAZ2A represses rRNA genes (rDNA) that are transcribed by RNA polymerase I. In prostate cancer (PCa), BAZ2A function goes beyond this role because it represses genes frequently silenced in metastatic disease. However, the mechanisms of this BAZ2A-mediated repression remain elusive. Here, we show that BAZ2A represses genes through its RNA-binding TAM domain using mechanisms differing from rDNA silencing. Although the TAM domain mediates BAZ2A recruitment to rDNA, in PCa, this is not required for BAZ2A association with target genes. Instead, the BAZ2A-TAM domain in association with RNA mediates the interaction with topoisomerase 2A (TOP2A) and histone demethylase KDM1A, whose expression positively correlates with BAZ2A levels in localized and metastatic PCa. TOP2A and KDM1A pharmacological inhibition up-regulate BAZ2A-repressed genes that are regulated by inactive enhancers bound by BAZ2A, whereas rRNA genes are not affected. Our findings showed a novel RNA-based mechanism of gene regulation in PCa. Furthermore, we determined that RNA-mediated interactions between BAZ2A and TOP2A and KDM1A repress genes critical to PCa and may prove to be useful to stratify prostate cancer risk and treatment in patients.
Application of Non-Destructive Testing Technology in Quality Testing and Control of Water Conservancy Projects
Authors: Zhou Yang
Published: April 2023

In view of social development, the demand for water conservancy engineering applications continues to increase. The number and scale of water conservancy projects in China have been in a state of continuous expansion in recent years. As a result, how to achieve efficient testing and effective control of the quality of water conservancy projects has always been a topic of discussion in the field of water conservancy engineering in our country. This paper summarizes the application of non-destructive testing technology in the quality testing and control of water conservancy projects. On the basis of explaining the connotation and application advantages of non-destructive testing technology, the non-destructive testing application strategies for concrete strength, steel corrosion and shallow cracks in water conservancy projects were studied.
Construction Technology and Safety Risk Control Measures of Deep Foundation Pit Excavation
Authors: Jiang Mingmin
Published: April 2023

Deep foundation pit excavation is a basic and key step involved in modern building construction. In order to ensure the construction quality and safety of deep foundation pits, this paper takes a project as an example to analyze deep foundation pit excavation technology, including the nature of this construction project, the main technical measures in the construction of deep foundation pit, and the analysis of the safety risk prevention and control measures. The purpose of this analysis is to provide scientific reference for the construction quality and safety of deep foundation pits.
Investigation of the microstructure, hardness, and compressive properties of TaC-reinforced lamellar graphite cast irons
Authors: YAKUT Rifat , ÇİFTÇİ Ömer
Published: April 2023

Tantalum Carbide (TaC) reinforcement was made to lamellar graphite (gray) cast irons that were produced in the physical conditions of a foundry at reinforcement ratios of 0%, 0.025%, 0.155%, and 0.285%. Samples complying with standards were prepared using the TaC-reinforced lamellar graphite (gray) cast iron alloys that were produced, and Brinell hardness tests, compressive strength tests, and microstructural analyses were conducted. According to the test results, the highest average Brinell hardness value was found as 231 HB in sample A which was reinforced at a ratio of 0.025%. In general, as the reinforcement ratio increased, there was an increase in the hardness test measurement results. The highest average compressive strength value was found as 949 MPa in sample C which was reinforced at a ratio of 0.285%. In general, as the reinforcement ratio increased, there was an increase in the compressive strength values. The results of the microstructural analyses showed that the reinforcement material was dispersed into the matrix.
A Model Predicting Student Engagement and Intention with Mobile Learning Management Systems
Authors: Imlawi Jehad , AL-Shatnawi Atallah , M AlFawwaz Bader , M AL-Shatnawi Hasan , Al-masaeed Sultan
Published: April 2023

Aim/Purpose: The aim of this study is to develop and evaluate a comprehensive model that predicts students’ engagement with and intent to continue using mobile-Learning Management Systems (m-LMS).

Background: m-LMS are increasingly popular tools for delivering course content in higher education. Understanding the factors that affect student engagement and continuance intention can help educational institutions to develop more effective and user-friendly m-LMS platforms.

Methodology: Participants with prior experience with m-LMS were employed to develop and evaluate the proposed model that draws on the Technology Acceptance Model (TAM), Task-Technology Fit (TTF), and other related models. Partial Least Squares-Structural Equation Modeling (PLS-SEM) was used to evaluate the model.

Contribution: The study provides a comprehensive model that takes into account a variety of factors affecting engagement and continuance intention and has a strong predictive capability.

Findings: The results of the study provide evidence for the strong predictive capability of the proposed model and supports previous research. The model identifies perceived usefulness, perceived ease of use, interactivity, compatibility, enjoyment, and social influence as factors that significantly influence student engagement and continuance intention.

Recommendations for Practitioners: The findings of this study can help educational institutions to effectively meet the needs of students for interactive, effective, and user-friendly m-LMS platforms.

Recommendation for Researchers: This study highlights the importance of understanding the antecedents of students’ engagement with m-LMS. Future research should be conducted to test the proposed model in different contexts and with different populations to further validate its applicability.

Impact on Society: The engagement model can help educational institutions to understand how to improve student engagement and continuance intention with m-LMS, ultimately leading to more effective and efficient mobile learning.

Future Research: Additional research should be conducted to test the proposed model in different contexts and with different populations to further validate its applicability.
Bilişim Öğrencilerinin Uzun Staj Eğitimi Ve İstihdam Deneyimleri
Authors: ÇELİK Cemal , KIVRAK Oğuzhan
Published: April 2023

İş dünyasında yaşanan teknolojik gelişmeler, iş süreçlerinde; nitelikli ve iyi yetişmiş insan ihtiyacını da beraberinde getirmiştir. Talep ve tercihlere dönük insan kaynağı ihtiyacı, meslek yüksekokulları tarafından, eğitim ve öğretim programlarına eklenen staj eğitimleri ile giderilmeye çalışılmıştır. 3+1 adı altında anılan eğitim programları, 3 yarı dönem okulda 1 yarı dönem işletmelerde eğitim alacak şekilde planlanarak, öğrenci becerilerinin; iş piyasasıyla ilişkilendirilmesi hedeflenmiştir. Bu çalışmada, 3+1 eğitim ve öğretim programında, eğitim almış bilgisayar teknolojileri öğrencilerinin, iş yeri eğitimi sonrası istihdam edilmelerini sağlayan işletme deneyimleri değerlendirilmeye çalışılmıştır. Araştırma; nitel araştırma yöntemlerinden biri olan durum çalışması çerçevesinde gerçekleşmiştir. Veriler; görüşme formu tekniğinden yararlanılarak, Zoom yazılımı üzerinden belge sistemine göre dijital olarak kayıt edilmiştir. Soru formunda yer alan üst başlıklar, ana tema, üst başlığa bağlı alt başlıklarda, alt temalar olarak kodlanmıştır. Tema kodların 13 tanesi üst başlık, 32 tanesi alt başlıktan oluşmuştur. Kodlanan veriler, içerik analizi yöntemiyle değerlendirilmiş ve verilerin analizinde MAXQDA analiz programı kullanılmıştır. Çözümleme bulguları, çalışmanın hedefleri doğrultusunda tartışılmış ve çalışma amacına dönük; uygulama paydaşları içerisinde yer alan öğrenci, okul ve işletme aktörlerine yönelik sonuç ve öneriler çıkarılmıştır.