bluuebunny/crossref_metadata_2025 huggingface dataset:
Paraesophageal hernia mimicking pneumatocele in an infant: A diagnostic dilemma
Authors: Chirag Ravi , Babu Thirunavukkarasu Arun
Published: April 2024

A defect in the oesophageal hiatus can result in the herniation of the stomach or other abdominal organs into the thoracic cavity, known as a hiatal hernia. These hernias are uncommon in infants and children, and their symptoms can be vague and non-specific, posing challenges for even experienced clinicians to make a diagnosis. Regardless of the case, surgical intervention is necessary due to the potentially life-threatening complications associated with this condition. We present a rare case of a 2-month-old infant with congenital paraesophageal hernia (PEH) who initially came to our hospital with a diagnosis of pneumonia with pneumatocele. Based on clinical presentation and radiological examinations, the infant was correctly diagnosed with PEH and gastric volvulus. The patient underwent emergency surgical correction and was discharged in a stable condition. It is crucial to have a thorough understanding of the clinical presentation and maintain a high level of suspicion to ensure timely diagnosis and appropriate management in these cases.
From Enigma to Revelation: Unravelling Biological Functions of Ubiquitous Small Ribozymes
Authors: Kienbeck Kasimir , Malfertheiner Lukas , Zelger-Paulus Susann , Johannsen Silke , Von Mering Christian , Sigel Roland K. O.
Published: April 2024

RNA, widely recognized as an information-carrier molecule, is capable of catalyzing essential biological processes through ribozymes. Despite their ubiquity, specific functions in a biological context and phenotypes based on the ribozymes' activity are often unknown. Here, we present the discovery of a subgroup of minimal HDV-like ribozymes, which reside 3' to viral tRNAs and appear to cleave the 3'-trailers of viral premature tRNA transcripts. This proposed tRNA-processing function is unprecedented for any ribozymes, thus, we designate this subgroup as theta ribozymes. Most theta ribozymes were identified in Caudoviricetes bacteriophages, the main constituent (>90%) of the mammalian gut virome. Intriguingly, our findings further suggest the involvement of theta ribozymes in the transition of certain bacteriophages between distinct genetic codes, thus possibly contributing to the phage lysis trigger. Our discovery expands the limited repertoire of biological functions attributed to HDV-like ribozymes and provides insights into the fascinating world of RNA catalysis.
Antibiotics Uptake from Soil and Translocation in the Plants – Meta-analysis
Authors: Nybom Inna , Bucheli Thomas D. , Garland Gina
Published: April 2024

Antibiotics reach agricultural soils via fertilization with manure and biosolids as well as irrigation withwastewater and have the potential to be taken up by growing crops. The fate of antibiotics in terms of uptakefrom soil to plants, as well as translocation from root to leaves, is determined by a combination of antibiotic’sphysio-chemical (e.g. speciation, lipophilicity), soil (e.g. organic carbon content, pH) and plant (e.g.transpiration rates) characteristics. In this meta-analysis, a literature search was executed to obtain an overview of antibiotic uptake to plants, with an aim to identify uptake and translocation patterns of different antibiotic classes. Overall, we found that higher uptake of tetracyclines to plant leaves was observed compared to sulfonamides. Differences were also observed in translocation within the plants, where tetracyclines were found in roots and leaves with close to equal concentrations, while the sulfonamides represented a tendency to accumulate to the root fraction. The antibiotic’s characteristics have a high influence on their fate, for example, the high water-solubility and uncharged speciation in typical agricultural soil pH ranges likely induces tetracycline uptake from soil and translocation in plant. Despite the advances in knowledge over the past decade, our meta-analysis indicated that the available research is focused on a limited number of analytes and antibiotic classes. Furthermore, fastgrowing plant species (e.g. spinach, lettuce, and radish) are overly represented in studies compared to crop species with higher significance for human food sources (e.g. corn, wheat, and potato), requiring more attention in future research.
Towards Greener and More Cost-efficient Biosynthesis of Pharmaceuticals and Fragrance Molecules
Authors: Benítez Mateos Ana I.
Published: April 2024

Enzymes are natural catalysts which are gaining momentum in chemical synthesis due to their exquisiteselectivity and their biodegradability. However, the cost-efficiency and the sustainability of the overall biocatalytic process must be enhanced to unlock completely the potential of enzymes for industrial applications. To reach this goal, enzyme immobilization and the integration into continuous flow reactors have been the cornerstone of our research. We showed key examples of the advantages of those tools for the biosynthesis of antivirals, anticancer drugs, and valuable fragrance molecules. By combining new strategies to immobilize biocatalysts, innovative bioengineering approaches, and process development, the performance of the reactions could be boosted up to 100-fold.
Extending Droplet-Based Microfluidic Tools to Single-Atom Heterogeneous Catalysis
Authors: Moragues Thomas
Published: April 2024

From energy-related transformations to organic syntheses, single-atom heterogeneous catalysts (SACs) are offering new prospects to tackle sustainability challenges. However, scarce design guidelines and poor mechanistic understanding due to a lack of discovery and operando characterization tools impede theirbroader development. This perspective offers a glimpse into how droplet-based microfluidic technologies mayhelp solve both of these issues, and provides technical considerations for platform design to systematically fabricate SACs and study them under operational conditions during liquid-phase organic syntheses.
Using Instanton Theory to Study Quantum Effects in Photosensitization
Authors: Manae Meghna A. , Richardson Jeremy O.
Published: April 2024

Electronic excitation is usually accomplished using light (photoexcitation) and is a key step in a vast number of important physical and biological processes. However, in instances where photoexcitation is not possible, a photosensitizer can excite the target molecule in a process called photosensitization. Unfortunately, full details of its mechanism are still unknown. This perspective gives an overview of the current understanding of photosensitization and describes how instanton theory can be used to fill the gaps, especially with regard tothe importance of quantum tunnelling effects.
Oxidative Defect Detection Within Free and Packed DNA Systems: A Quantum Mechanical/Molecular Mechanics (QM/ MM) Approach
Authors: Johnson Sophia , Rothlisberger Ursula
Published: April 2024

Base excision repair enzymes (BERs) detect and repair oxidative DNA damage with efficacy despite the small size of the defects and their often only minor structural impact. A charge transfer (CT) model for rapid scanning of DNA stretches has been evoked to explain the high detection rate in the face of numerous, small lesions. The viability of CT DNA defect detection is explored via hybrid QM/MM computational studies that leverage the accuracy of quantum mechanics (QM) for a region of interest and the descriptive power of molecularmechanics (MM) for the remainder of the system. We find that the presence of an oxidative lesion lowers theredox free energy of oxidation by approximately 1.0 eV regardless of DNA compaction (free DNA versus packed DNA in nucleosome core particles) and damage location indicating the high feasibility of a CT-based process for defect detection in DNA.
Advances in Oxygen Isotope Analysis of Phosphate by Electrospray Orbitrap Mass Spectrometry for Studying the Microbial Metabolism of Microorganisms
Authors: Bernet Nora M. , Hofstetter Thomas B.
Published: April 2024

Understanding the impact of human activities on the metabolic state of soil and aquatic environments is of paramount importance to implement measures for maintaining ecosystem services. Variations of natural abundance 18O/16O ratios in phosphate have been proposed as proxies for the holistic assessment of metabolic activity given the crucial importance of phosphoryl transfer reactions in fundamental biological processes. However, instrumental and procedural limitations inherent to oxygen isotope analysis in phosphate and organophosphorus compounds have so far limited the stable isotope-based evaluation of metabolic processes. Here, we discuss how recent developments in Orbitrap high resolution mass spectrometry enable measurements of 18O/16O ratios in phosphate and outline the critical mass spectrometry parameters for accurate and precise analysis. Subsequently, we evaluate the types of 18O kinetic isotope effects of phosphoryl transfer reactions and illustrate how novel analytical approaches will give rise to an improved understanding of 18O/16O ratio variations from biochemical processes affecting the microbial phosphorus metabolism.
Holoprozencefalie lobară asociată diabetului zaharat matern – prezentare de caz
Authors: Voicu Diana Ioana , Cîrstoiu Monica Mihaela
Published: April 2024

Holoprosencephaly is a brain abnormality resulting from an incomplete cleavage of the prosencephalon during early embryogenesis. Uncontrolled maternal diabetes mellitus is one of the strongest human teratogens and the most well-known cause of holoprosencephaly. We report a rare case of holoprosencephaly in a male fetus in a preexisting diabetic pregnancy. The diagnosis of the holoprosencephaly was established by ultrasound scan and MRI data.
Nodul fibromatos gigant istmic cu dezvoltare la nivelul colului uterin – caz clinic
Authors: Popovici Diana , Socolov Răzvan , Anton Emil , Hurjui Loredana , Stan Cătălina , Bălan Raluca , Bradea Costel , Hurjui Ion , Hurjui Andrei , Bereşteanu Svetlana , Rusu Florina-Iuliana , Anton Sorana-Caterina
Published: April 2024

Isthmic-cervical leiomyomas can grow very large and cause extreme discomfort. The surgical removal of these leio­myo­mas is a technical challenge, with an increased risk of operative and postoperative complications. This paper presents the case of a patient with a gynecopathy who presented herself to our clinic, having been diagnosed with a giant isthmic-cervical fibromatous nodule which was developing within the cervix and required extended surgery – i.e., the radical dissection of the pelvis, to ensure the suc­cess of the total en bloc hysterectomy. The radical pelvic dis­sec­tion at the time of the total en bloc hysterectomy is necessary in most cases of large isthmic-cervical fibroids, to minimize the risk of intraoperative and postoperative com­pli­ca­tions. These isthmic-cervical fibroids have a very dif­fi­cult surgical approach. Ideally, the medical team should be pluridisciplinary, and the gynecologist should do the sur­gery together with a general surgeon and a urologist. To con­clude, the surgical treatment of giant isthmic-cervical fi­bro­ids should be personalized and individualized.
Metal-Free Radical Vicinal Dihalogenation of Olefins Enabled by Synergetic Photocatalytic Energy Transfer and Halogen-Atom Transfer
Authors: Han Bing , Wang Hong-Chen , Qi Min-Hao , Liu Tu-Ming , Zhao Peng-Fei , Xu Chang-Yuan , Xie Dong- Tai , Jiang Hao-Luo , Li Yi-Fan , Wang Xiao-Heng
Published: April 2024

Vicinal dihaloalkane is extremely important structural unit, and dihalogenation of alkene provides a prospective way access to such moiety. Despite more than a century of development, it is still challenging and necessary to avoid the use of toxic and harmful halogenating reagents and to develop more efficient, sustainable, and broader functional group tolerant and skeleton-compatible strategies. We report herein the first metal-free protocol for radical vicinal dichlorination and dibromination by a photocatalytic energy transfer strategy using N-halo-benzophenonimine (NXB) as the readily accessible halogenating reagents. This approach undergoes the radical addition of a halogen atom derived from the N-X bond photolysis of NXB onto olefins, followed by a halogen-atom transfer process. This approach features facile operation, mild reaction conditions, a wide of functional group tolerance, and is compatible with a large of complex scaffolds such as unsaturated fatty acid, terpenes steroid, alkaloid, sugar, amino acid, and peptide.
Mechanism of Nucleic Acid Phosphodiester Bond Cleavage by Human Endonuclease V: MD and QM/MM Calculations Reveal a Versatile Metal Dependence
Authors: Kaur Rajwinder , Wetmore Stacey
Published: April 2024

Human endonuclease V (EndoV) catalytically removes deaminated nucleobases by cleaving the phosphodiester bond as part of RNA metabolism. Despite being implicated in several diseases (cancers, cardiovascular diseases, and neurological disorders) and potentially being a useful tool in biotechnology, details of the human EndoV catalytic pathway remain unclear due to limited experimental information beyond a crystal structure of the apo-enzyme and select mutational data. Since a mechanistic understanding is critical for further deciphering the central roles and expanding applications of human EndoV in medicine and biotechnology, molecular dynamics (MD) simulations and quantum mechanics-molecular mechanics (QM/MM) calculations were used to unveil the atomistic details of the catalytic pathway. Due to controversies surrounding the number of metals required for nuclease activity, enzyme–substrate models with different numbers of active site metals and various metal–substrate binding configurations were built based on structural data for other nucleases. Subsequent MD simulations revealed the structure and stability of the human EndoV–substrate complex for a range of active site metal binding architectures. Four unique pathways were then characterized using QM/MM that vary in metal number (one versus two) and modes of substrate coordination (direct versus indirect (water-mediated)), with several mechanisms being fully consistent with experimental structural, kinetic, and mutational data for related nucleases, including members of the EndoV family. Beyond uncovering key roles for several active site amino acids (D240 and K155), our calculations highlight that, while one metal is essential for human EndoV activity, the enzyme can benefit from using two metals due to the presence of two suitable active site binding sites. By directly comparing one versus two-metal-mediated P–O bond cleavage reactions within the confines of the same active site, our work brings a fresh perspective to the ‘number of metals’ controversy.
δ-Bonding and Electron Localisation in Crystalline Divalent Rare Earth Arene Complexes
Authors: MacKenzie Ross , Hajdu Tomáš , Seed John , Whitehead George , Adams Ralph , Chilton Nicholas , Collison David , McInnes Eric , Goodwin Conrad
Published: April 2024

Landmark advances in rare earth (RE) chemistry have shown that formally divalent complexes can be isolated with non-Aufbau 4fn5d(dz2)1 or 4fn{5d/6s}1 electron configurations, which facilitate novel bonding motifs and phenomenal magnetic properties. We report an unprecedented series of divalent bis-tethered arene complexes, [RE(NHAriPr6)2] (2RE; RE = Sc, Y, La, Sm, Eu, Tm, Yb; NHAriPr6 = {N(H)C6H3-2,6-(C6H2-2,4,6-iPr3)2}), where 2Sc, 2Y, and 2La show metal-arene δ-bonding via nd(x2-y2)- and π* orbital mixing, while 2Sm, 2Eu, 2Tm, and 2Yb contain 4fn+1 ions without δ-bonds. Fluid solution EPR spectroscopy gives giso = 1.9995, 1.998, 1.989 for 2Sc, 2Y, and 2La, respectively, consistent with formal nd1 configurations, while metal hyperfine interactions suggest extensive delocalisation. Solution and crystalline phase EPR and UV-Vis-NIR spectroscopy for 2Y show incongruities due to minor structural changes between these phases that markedly alter the metal 4d(x2-y2) character to the SOMO (22% vs 12%, respectively). In contrast to existing 4fn5d(dz2)1 or 4fn{5d/6s}1 complexes where the valence d-based electron resides in a non-bonding orbital, the sensitivity of 2Y to its local environment suggests RE(II) arene δ-bonding represents a hitherto unexplored opportunity to tune the electronic structure properties of nd1 rare earth ions.
Controlling structure and morphology of MoS2 via sulfur precursor for optimized pseudocapacitive lithium intercalation hosts
Authors: Tobis Maciej , Elmanzalawy Mennatalla , Choi Jaehoon , Frąckowiak Elżbieta , Fleischmann Simon
Published: April 2024

Molybdenum disulfide (MoS2)-based electrode materials can exhibit a pseudocapacitive charge storage mechanism induced by nanosized dimension of the crystalline domains. This effect is achievable through hydrothermal synthesis of MoS2, which often yields different properties of the final material, thereby affecting its electrochemical lithium intercalation behavior. In this study, we investigate how the use of different sulfide precursors, specifically thiourea (TU), thioacetamide (TAA), and L-cysteine (LC), during the hydrothermal synthesis of MoS2, affects its physicochemical, and consequently, electrochemical properties. The three materials obtained exhibit distinct morphologies, ranging from micron-sized architectures (MoS2 TU), to nanosized flakes (MoS2 TAA and LC), which influence their available specific surface area and tortuosity. Consequently, the choice of hydrothermal synthesis parameters allows to control the resulting electrochemical signature. The individual charge storage properties are analyzed by operando X-ray diffraction, dilatometry, and 3D Bode analysis, revealing a correlation between the morphology, porosity, and the electrochemical intercalation behavior of the obtained electrode materials. The results demonstrate a facile strategy to control MoS2 structure and related functionality by choice of hydrothermal synthesis precursors.
Reactive Processing of Furan-Based Monomers via Frontal Ring-Opening Metathesis Polymerization for High Performance Materials
Authors: Xu Zhenchuang , Chua Lauren , Singhal Avni , Krishnan Pranav , Lessard Jacob , Suslick Benjamin , Chen Valerie , Sottos Nancy , Gomez-Bombarelli Rafael , Moore Jeffrey
Published: April 2024

Frontal ring-opening metathesis polymerization (FROMP) presents an energy-efficient approach to produce high-performance polymers, typically utilizing norbornene derivatives from Diels-Alder reactions. This study broadens the monomer repertoire for FROMP, incorporating the cycloaddition product of biosourced furan compounds and benzyne, namely 1,4-dihydro-1,4-epoxynaphthalene (HEN). We conducted a computational screening of Diels-Alder products, selecting products with resistance to retro-Diels-Alder but also sufficient ring strain to facilitate FROMP. Our experiments revealed that varying substituents both modulate the FROMP kinetics and enable the creation of thermoplastic materials characterized by different thermomechanical properties. Moreover, we designed HEN-based crosslinkers to enhance the resulting thermomechanical properties at high temperatures (>200 °C). The versatility of such materials was demonstrated through direct ink writing (DIW) to rapidly produce 3D structures without the need of printed supports. This research significantly extends the range of monomers suitable for FROMP, paving the way for efficient production of advanced thermoplastic materials.
Bipolar electrochemical growth of conductive microwires for cancer spheroid integration: A step forward in conductive biological circuitry
Authors: Robinsons Andie , McBeth Craig , Rahman Ruman , Hague Richard , Rawson Frankie
Published: April 2024

The field of bioelectronics is developing exponentially. There is now a drive to interface electronics with biology for the development of new technologies to improve our understanding of electrical forces in biology. This builds on our recently published work in which we show wireless electrochemistry could be used to grow bioelectronic functional circuitry in 2 dimensional (2D) cell layers. To date our ability to merge electronics with biology which is 3 dimentional (3D) is limited. In this study, we aimed to further develop the wireless electrochemical approach for the self-assembly of microwires in-situ with custom-designed and fabricated 3D cancer spheroids. Thereby, creating interlinked bioelectronic circuitry with cancer spheroids. We demonstrate that a direct current was needed to stimulate the growth of conductive microwires in the presence of cell spheroids. Microwire growth was successful when using 50 V (0.5 kV/cm) of DC applied to a single spheroid of approximately 800 m in diameter but could not be achieved with alternating currents. This represents the first proof of the concept of using wireless electrochemistry to grow conductive structures with 3D mammalian cell spheroids.
Harnessing Liquid Crystal Attributes of Near-Unit Photoluminescent Benzothioxanthene Photosensitizers: Photophysical Profiling in Solution, Solid State, and Polymer Matrix Embedding
Authors: Duarte Frederico , Morice Korentin , Ghanem Tatiana , Puchan Sánchez Dario , Blanchard Philippe , S.B. Gomes Clara , Herrero Santiago , Cabanetos Clement , Cuerva Cristian , Capelo-Martínez José Luis , Lodeiro Carlos
Published: April 2024

Liquid crystals (LCs) have garnered significant attention for their unique optical and electrical properties, making them promising candidates in various technological applications such as smart displays, sensors, telecommunications, biomedicals or wearable electronics. In this study, we explore the potential of several highly emissive benzothioxanthene imide (BTI) derivatives as LC materials with a focus on their robustness and temperature-stable emission behavior. By tailoring the molecular structure of BTIs, we have accomplished exceptional emissive properties while maintaining the inherent advantages of LCs, such as their self-organizing ability and responsive nature. We describe the formation of enantiotropic liquid crystals whose mesomorphic properties dependent on the nature, length, and position of the side chain. Moreover, we have investigated the thermal stability of their emission spectra over a wide range of temperature, highlighting their potential use in demanding conditions where precise optical performances are critical. Our findings underscore the importance of molecular design in achieving highly emissive LC materials with enhanced robustness and temperature stability, opening new avenues for the use of BTI derivatives.
Assessing the accurate exchange-correlation functional in van der Waals TMD Materials AB2 (A = Nb, Ta and B = S, Se, Te)
Authors: Behera Sushant Kumar , Ramamurthy Praveen C
Published: April 2024

Two-dimensional (2D) transition metal dichalcogenides (TMDs) exhibit diverse functionalities owing to their highly tunable chemical, physical, and electronic attributes. In this study, we systematically investigate the structural, electronic, and phonon responses of six TMD systems using density functional theory (DFT) simulations. Our analysis unveils a reversible phase transition between the semiconducting (2H) and metallic (1T) phases within the stable phases of these TMD systems. Specifically, group-V TMDs (AB 2, where A = Nb, Ta and B = S, Se, Te) systems are focused in the present calculations. Their electronic behavior has been evaluated to validate the accuracy of several available exchange-correlation (XC) functionals, along with van der Waals density functionals (vdW-DFs). Both spin-orbit coupling (SOC) effects and non-SOC (NSOC) cases are considered in our calculations. Notable changes in the electronic band structure and density of states between the 2H and 1T phases underscore their potential utility in conventional device applications.
Social entrepreneurship and the creation of social value: the case in the Mexico northeast
Authors: Rubalcava de León Cristian Alejandro
Published: April 2024

Social entrepreneurship (SE) has been observed as a process in companies, while the figure of the social enterprise gains relevance as a perfect unit of analysis to evaluate it. The objective is to determine the effect of social entrepreneurship in the creation of social value at Huasteca Tamaulipeca of Mexico, a region that offers different conditions to those traditionally approached worldwide. A model was test using a sample of 148 observations with partial least squares (PLS) as the technique. The dimensions of ES innovativeness, risk management and socialness have direct effects on the creation of social value. The results provide an overview of the social entrepreneurship, positioning it as an important tool to create social value.
Systematic review of the scientific literature related to the quintuple helix innovation model and its correlation with business profitability: a bibliometric analysis
Authors: Maza y Ferrer Miguel Francisco , De La Torre Torres Oscar V. , Galeana Figueroa Evaristo
Published: April 2024

The objective of this research is to conduct a systematic review of the scientific production related to the quintuple helix innovation model. Specifically, it seeks to identify if there are previous works that establish a relationship between said innovation model and business profitability. The methodology is based on a bibliometric analysis of the scientific literature in the academic database Dimensions. The results of the analysis suggest that there are no scientific works that directly relate the quintuple helix innovation model with business profitability.
Conceptual model of the participation of Mexican SMEs in the Stakeholder Capitalism of the post-COVID19 era
Authors: Esparza-Rodriguez Saul Alfonso , Esquivel Fernández Enrique , Chavez Gallegos Glenda Marisa , Garcia Tapia Gabino , Raziel Rodríguez Paulo
Published: April 2024

The crisis caused by COVID-19 was an event experienced globally and simultaneously, generating changes in the way people work, study, and carry out their social activities, giving the beginning of practical and theoretical conversations about the need to design and implement a new model of capitalism, oriented to the management of interest groups. The present work presents the theoretical and conceptual review related to the theoretical and conceptual constructs related to the contribution to the planet, people management, prosperity orientation, and governance factors that explain the participation of Mexican SMEs in interest group capitalism. Thus, it is shown that the process of adaptation to a "new normality" scenario will represent a factor of fundamental importance for social coexistence considering the risk represented by the effects caused by the new coronavirus, through the development of emerging strategies characterized by promoting the Adequate interaction between interested parties that constitute a model of capitalism that must equally weigh the social, economic, environmental and health dimensions for society in the long-term.
Some issues of global problems in the changing system of values of the modern world
Authors: Hrushchynska Natalia
Published: April 2024

The article analyzes the peculiarities of global problems in the modern world system, their transformation, identification of more acute issues, taking into account the urgent issue of the security of each country, food security against the background of the growth of the total population of the planet. Issues of environmental protection and climate change. Modifications of global problems, taking into account wars and their consequences, along with the active phase of the Fourth Industrial Revolution, the development of artificial intelligence, which leads to the emergence of new professions, new forms of employment of the population, the development of humanity in general and, of course, affects the changes in the values of every society. The article analyzes the historical perspective of economic and social changes and the influence of technological processes, assesses the impact of the war on the economic and demographic components of society. It is noted that the results of the fourth industrial revolution, the emergence and development of artificial intelligence are a breakthrough for the survival of mankind. Artificial intelligence (AI) is rapidly transforming various industries, and environmental protection and climate change are no exception. The modern world transforms a person's way of life, forms of communication, changes the characteristics of relationships, views on the same things, manners of communication, and ultimately, values. In the articles of philosophers, economists, and psychologists who are engaged in researching the problems of forming the society of the future, the emergence of the technological structure of psychotechnologies and technologies related to moral responsibility is noted. Changes in the technological stages of society are accompanied by changes in society itself. Values influence people's desire to realize themselves and, accordingly, the sphere of employment. In the context of world transformations, there are changes in the values of society. Values can be divided into groups and everyone determines their priority (material, spiritual values (vital, moral, aesthetic), social, family values, the value of pleasure, health. Each person takes his place in society, which determines social values that depend from the environment, from needs, from goals, and they can change during life.Self-discovery is the deepest way of assessing one's values.
Ecologization of tourist activities as a factor of sustainable development of the regions of Ukraine
Authors: Haponenko Hanna , Listratenko Denys , Yevtushenko Olena , Shamara Irina
Published: April 2024

The article is devoted to the problem of sustainable development of Ukraine's regions, since competitive regions are a source of balanced and sustainable development of the entire country. It was emphasized that the development of the development management strategy of any region of Ukraine should be based on the environmental safety policy, the current norms and requirements of which must be adapted in accordance with European standards. The subject of the study is the greening of tourist activity as a factor in the sustainable development of the regions of Ukraine. The purpose of the study is to build a model of sustainable development of regional tourism based on the ecosystem restoration of security of the tourist and recreational potential of Ukraine in the post-war period. Tasks that were set to achieve the goal: to investigate the management mechanism of sustainable development of regional tourism; to analyze the impact of military actions on the ecological state of the regions of Ukraine; to propose a program model for the sustainable development of tourism in Ukraine. In accordance with this direction of research, the author chose and applied the following methodological approaches: systemic and institutional when considering the interrelationships of actors at both the national and regional levels. Within the framework of the system approach, the functioning of the tourism industry of Ukraine was investigated within the framework of new ecological realities. Thanks to the institutional approach, the necessary legal framework for the sustainable development of tourism was considered. The following results were obtained. The authors proposed the formation of a model of sustainable development of tourism, which emphasizes the sustainability of ecological, economic, cultural and social spheres, taking into account the ranking of factors of sustainable development depending on the level of sustainability. The proposed model takes into account an important aspect - after the war, it will be necessary to ensure different levels of sustainability for individual regions of Ukraine.
Suicides of famous chefs of today: stories and reasons
Authors: Nykyha Oksana , Romanchuk Olha , Koval Rostyslav , Danylevych Myroslava , Kalymon Yuliia
Published: April 2024

Suicide and suicidal behavior are one of the key issues for public policy and health care. Well-known American psychiatrist Somya Abubucker states that according to the WHO, a death by suicide occurs every 40 seconds in the world and “there are indications that for every adult person who died by suicide, there could be more than twenty others who attempted to commit it”. Restaurants remain a highly stressful environment, with the chef profession ranking among the top 10 most nerve-racking jobs in the world. The aim of the article is to present the life story and professional activity of the world’s most famous chefs and restaurateurs who committed suicide over the past 30 years, as well as the analysis of the probable reasons for their actions. To achieve the declared goal, the following research methods were used: historical, descriptive, comparative, systematization and generalization. The chefs in question used to work in the best restaurants in the United States, Canada, France, Italy, Switzerland, Great Britain and Australia. They made a significant contribution to the development of world gastronomy, their establishments have been transformed into truly cult locations, awarded stars from «Michelin» and evaluations from «Gault & Millau», which have been operating for several decades and offering the most exquisite dishes. It was established that the reasons for their suicides were mostly depression, emotional exhaustion and burnout, economic crisis, a drop in profits and lower ratings, loss of a loved one / close person, influence of reality shows, constant pressure, irregular work schedule, unjustified accusations. It was found that among the methods of suicide, it is, in particular, hanging, use of firearms, drowning and suffocation, medicine and drug overdose. The motives of the actions of some of them remained a mystery, since not even suicide notes were found. Priorities for suicide prevention include increasing specialized mental health programs, restricting access to weapons, and strengthening surveillance to detect signals / reports / information that a person is exhibiting suicidal intent. The obtained results make it possible to supplement and expand specialized training courses in higher education institutions of Ukraine, where personnel are trained for the field of tourism, hotel and restaurant industry, as well as medicine (in particular, psychology, psychiatry, addictionology and rehabilitation).
CONCEPÇÕES ALTERNATIVAS NO ENSINO DE MATEMÁTICA SOBRE OS CONCEITOS DE FRAÇÃO, PRODUTOS NOTÁVEIS, ÁREA E PERÍMETRO
Authors: Silva Luciane Alcântara da , Silva Lucas Cunha da , Feitosa Francisco Eteval da Silva
Published: April 2024

O presente estudo apresenta resultados de uma pesquisa qualitativa com procedimentos bibliográficos, na qual objetivou-se identificar concepções alternativas relacionadas a conceitos matemáticos que são recorrentes, nos erros dos estudantes, presentes nos trabalhos científicos publicados.  Como suporte teórico, utilizou-se o conceito de Concepções Alternativas sob diferentes perspectivas teóricas, assim como o conceito de Obstáculos Epistemológicos de Gaston Bachelard. Foi levantada, para a análise de dados, uma concepção alternativa em Aritmética especificamente relacionada ao conceito de fração, uma em Álgebra relacionada a produtos notáveis e outra em Geometria sobre o conceito de área e perímetro. Os resultados obtidos poderão orientar novas pesquisas, bem como os professores de matemática a criarem estratégias didáticas que possibilitem melhores níveis de aprendizagem no ensino de matemática e, consequentemente, a aprendizagem significativa dos estudantes.
ENSINO POR INVESTIGAÇÃO COMO PROMOTOR DA APRENDIZAGEM SOBRE A FORMAÇÃO DOS SOLOS
Authors: Silva Dion Leno Benchimol , Malheiro João Manoel da Silva , Silva Claudio Emidio
Published: April 2024

A abordagem Ensino por Investigação pode ser utilizada no ensino de ciências para apresentar aos discentes saberes diversos, a partir de questionamentos relacionados ao cotidiano do aluno. O professor mediador auxilia o aluno por meio dos seus próprios questionamentos. O ensino acerca da formação das rochas é uma temática inserida no currículo do ensino de ciências e a problemática foi: como o ensino por investigação auxiliou no processo de ensino de ciências sobre a formação geológica a um aluno do quinto ano do ensino fundamental? Esta pesquisa de abordagem qualitativa, foi construída a partir da proposta de atividade experimental denominada “Formação das Gemas” através de uma Sequência de Ensino Investigativa (SEI) apresentada a um aluno do 5º ano do Ensino Fundamental I, com a seguinte questão norteadora: o que determina ou causa as diferentes características de formação das rochas? Após a realização da atividade, observou-se que sua compreensão sobre o tema mudou, a partir da mediação docente em meio a abordagem investigativa. O aluno observou e identificou a teoria que mais faria sentido e criou uma outra ou hipótese para responder aos questionamentos do docente. A forma de ensinar acerca da formação das rochas é uma temática inserida no currículo do ensino de ciências e o Ensino por Investigação poderá ser utilizado como abordagem alternativa nas aulas de ciências.
ЗНАЧЕННЯ ШТУЧНОГО ІНТЕЛЕКТУ У ВИВЧЕННІ ІНОЗЕМНИХ МОВ
Authors: Грачова І. Є. , Колот Л. A. , Дубініна О. B.
Published: April 2024

Освіта сьогодення – це якісне здобуття знань людиною, де особлива роль належить цифровізації, що робить процес мобільним, гнучким, персоналізованим і диференційованим. Метою дослідження є конкретизація поняття штучного інтелекту (ШІ) та визначення його ролі та значення як для викладача, так і для здобувача вищої освіти у процесі вивченні іноземних мов. Методи нашого дослідження: узагальнення та систематизація наукових джерел з елементами теоретичного аналізу та синтезу. Метод перекладу дозволив проаналізувати праці зарубіжних науковців, а метод вибірки сприяв виокремленню головних ідей із досліджуваної тематики. Штучний інтелект – це здатність машини до ефективного вирішення завдання з метою адекватної й успішної допомоги людині. Використання штучного інтелекту на заняттях з вивчення іноземних мов дає можливість виокремити низку особливостей. Для викладача – це колосальна допомога в економії часу, що полягає у множинному виборі; автоматизована перевірка виконаних робіт, можливість швидкого пошуку необхідної інформації, автоматизований переклад; безпосереднє залучення носіїв мови; моніторинг прогресу здобувачів з метою знаходження найбільш ефективних форм засвоєння знань; урахування особливостей кожного студента; автоматизована та негайна реакція на розвиток і модифікацію кіберзагроз. Для здобувача – це безперервне й автоматичне оцінювання; можливість ставити запитання та знаходити інформацію із предмета вивчення; навчання у відносно вільному середовищі; можлива зміна місця навчання, викладача та форми здобуття знань; навчання з будь-якої точки світу в будь-який час, персоналізоване навчання, постійна охорона персональних даних. До недоліків використання технології штучного інтелекту в системі вищої освіти у процесі опанування іноземних мова віднесено: неналежний розвиток критичного мислення у здобувачів знань, відсутність безпосереднього живого контакту між усіма учасниками; використання інших форм штучного інтелекту для вирішення поставлених завдань через небажання працювати самостійно; недоступність якісних додатків для вивчення іноземних мов через їхню вартість. Необхідність системного підходу до застосування технологій штучного інтелекту у процесі вивчення іноземних мов має стати рішенням через адаптивні навчальні програми. Перспектива подальших досліджень передбачає детальне вивчення новітніх форм штучного інтелекту, які стануть найбільш ефективними у процесі опанування іноземних мов.
ЛОГОРИТМІКА ЯК ЗАСІБ ДІАГНОСТИКИ ЗАЇКАННЯ В ДІТЕЙ ДОШКІЛЬНОГО ВІКУ
Authors: Рібцун Ю. В. , Майчук О. Є.
Published: April 2024

У статті схарактеризовано заїкання як одне з найскладніших комплексних нейромоторних порушень, у якому виокремлюють нейродинамічний (міжпівкульний дисбаланс, дисфункції нейронних зв’язків), неврологічний (органічна невропатія, резидуально-органічна церебральна недостатність тощо), руховий (загально- та мовленнєво-руховий), мовленнєвий (логопсихосинергетичний), психологічний (недостатність мнестичних операцій, мисленнєвих операцій самоконтролю, імовірного прогнозування, специфічні прояви емоційно-вольової сфери, зокрема, підвищена тривожність, логофобія, дезадаптаційні реакції), психосоматичний (розлади шлунково-кишкового тракту, часті респіраторно-інфекційні захворювання тощо) компоненти (Ю. Рібцун). Зважаючи на досить високу поширеність заїкання в популяції як у світі загалом, так і в Україні зокрема, особливо серед дитячого населення в сензитивному періоді розвитку психомовленнєвої діяльності, негативний вплив на збільшення зазначеного темпоритмічного порушення за умов пандемій і тривалих воєнних дій на території нашої держави, підкреслюється актуальність дослідження стосовно розроблення доступних методів логопсиходіагностики й ефективної логокорекції заїкання в дітей. Доступним і цікавим для дітей дошкільного віку засобом логопсиходіагностики може стати логоритміка у вигляді ігрових пізнавально-мовленнєвих завдань у поєднанні з музичним (пісенно- музичним), вербальним і руховим супроводом. Розроблений комплекс логопсиходіагностичних логоритмічних завдань був структурований (мета, попередня робота – за потреби, обладнання, музичний, мовленнєвий матеріал, перебіг проведення, інструкція) і апробований з дітьми старшого дошкільного віку із заїканням на базі логопедичної студії «Планета слова». Особливі труднощі в дітей фіксувалися під час обстеження темпоритмічної, дихальної, голосової функцій, привертали увагу недостатньо сформовані фонематичні уявлення та всі види праксису. Проведений кількісний і якісний аналіз результатів виконання проб дав змогу намітити подальші напрями логокорекційної роботи з дітьми із заїканням.
ФОРМУВАННЯ САМООСВІТНЬОЇ КОМПЕТЕНТНОСТІ УЧНЯ ПОЧАТКОВИХ КЛАСІВ ЯК ПЕДАГОГІЧНА ПРОБЛЕМА
Authors: Кравченко-Дзондза О. Е.
Published: April 2024

У статті розкрито сутність самоосвітньої компетентності учнів початкових класів, обґрунтовано необхідність її формування в початковій школі. У результаті аналізу досліджень науковців самоосвітню компетентність учня початкових класів визначено як інтегровану якість особистості, що базується на вміннях учня самостійно спланувати й організувати власну пізнавальну діяльність, спрямовану на отримання необхідної інформації, розвиток загальнокультурних якостей і самовдосконалення. Виокремлено структурні компоненти самоосвітньої компетентності: мотиваційно-смисловий, когнітивний, організаційно-діяльнісний, оцінювально-рефлексивний. Самоосвітня діяльність учня початкових класів складається з таких компонентів, як: розуміння власних потреб на підставі самоаналізу; організація самонавчання й уміння розв’язувати завдання; упорядкування та критичне ставлення до отриманої інформації; використання різноманітних джерел інформації; уміння долати труднощі, невпевненість; представлення й обґрунтування отриманих результатів; уміння використовувати нові технології інформації та комунікації; знаходження нестандартних рішень на основі самостійно набутих знань; постійний самоконтроль за самоосвітньою діяльністю. Згідно з логікою розвитку самоосвітньої компетентності виокремлено та проаналізовано основні етапи її формування в початковій школі: адаптаційний етап, етап накопичення досвіду, самоосвітній етап. Визначено завдання вчителя початкових класів щодо створення умов для успішного формування в учнів навичок самоосвітньої діяльності. Наголошено, що системно-діяльнісна парадигма освіти створює сприятливе освітнє середовище та сприяє формуванню вмінь і навичок самоосвіти. Виокремлено основні форми самоосвіти учня початкових класів: вивчення наукової, науково-популярної, художньої, навчальної літератури, використання різноманітних допоміжних засобів (консультації спеціалістів; прослуховування інтерв’ю; перегляд телепередач, фільмів, вистав; відвідування галерей, музеїв, виставок); ресурси мережі «Інтернет» (онлайн-курси, електронні підручники), віртуальна та доповнена реальність.
PECULIARITIES OF TEACHING COLORONYMS AT DIFFERENT LEVELS OF STUDYING A FOREIGN LANGUAGE IN HIGHER EDUCATION INSTITUTIONS
Authors: Соловйова О. В. , Чорна Ю. В.
Published: April 2024

The article is devoted to the peculiarities of teaching coloronyms at different levels of foreign language learning in institutions of higher education. The article notes that color is an important element of nature that affects the result of a person’s perception of the external world. An interpretation of the color terms at the modern stage is provided. The definition of the term “coloronym” is given separately and it is stated that this definition is the most appropriate for conveying the emotional and mental state of a person, his character traits, social and cultural aspects of life. Three groups of coloronyms are studied by meaning: initial, extended and abstract meaning. The article indicates that most color adjectives are represented by nouns that mean food, materials, plants, animals, birds, and natural phenomena. It is noted that learning color vocabulary is not only about recognition; it’s a fun way to learn a language that offers opportunities to practice grammar, expand vocabulary and have meaningful conversations. Particular attention is paid to the peculiarities of learning coloronyms for students with different levels of knowledge of a foreign language. It suggests that students should be introduced to the pronunciation and spelling of the primary colors at an early stage and use visual materials such as color cards, real objects or even presentations to effectively associate the colors with their names. When working with intermediate students, it is necessary to expand their language skills while delving into the subtleties of color perception. At this stage of learning, it necessary to develop roleplaying scenarios that require students to solve problems related to color. At the advanced level students already have a good understanding of color vocabulary and can explore complex concepts related to color. At this stage, thought-provoking activities and discussions are needed that promote students’ critical thinking. The article indicates that when teaching the vocabulary of colors, the teacher must choose the most effective method according to the goals and take into account the level of language proficiency of the students and the tasks set before the students, especially if they are learning a foreign language for special purposes.
Analysis of the Related Problems of Campus Green Space in Relieving College Students’ Psychological Stress
Authors: Liang Yimeng , Lu Feixiang , Li Hongping , Zhang Jun
Published: April 2024

This paper analyzes the problem of campus green space in relieving college students’ psychological pressure. It discusses this issue from five aspects: the source of pressure, the significance of alleviating pressure, the theoretical analysis of how green spaces can relieve pressure, the principles to be followed when using campus green spaces to alleviate pressure, and the selection of appropriate green spaces. Furthermore, it examines the role of campus green spaces in alleviating pressure for college students and proposes methods and principles for utilizing green spaces to relieve pressure. The aim is to summarize and analyze recent developments and accomplishments in utilizing green spaces for stress relief, thereby further guiding research in this area.
Analysis of Influencing Factors of Construction Cost Based on Building Information Model
Authors: Li Xiufang , Jia Xiaorui , Huang Mingqiang
Published: April 2024

Construction cost is a complex and multi-level system, influenced by many factors. By combining the risk influence factor analysis method with actual cost management, a knowledge graph model of the influencing parameters of construction project cost based on the Building Information Model (BIM) is established. The model includes two types of internal influence factors and external influence factors, focusing on analyzing and establishing the logical relationship between different influencing factors. The aim is to fully explore the influencing factors of construction costs and their cross-influencing relations under different stages and execution subjects, thus helping to realize effective control over the influencing factors of construction costs.