bluuebunny/crossref_metadata_2025 huggingface dataset:
HUBUNGAN GRANDPARENTING STYLE TERHADAP KESEJAHTERAAN PSIKOLOGIS LANSIA DI GABUNGAN ORGANISASI LANSIA
Authors: Suci Saraswati Latifah , Hamiyati  , Mulyati
Published: November 2021

ABSTRAK

 

Latifah Suci Saraswati. Hubungan Grandparenting Style terhadap Kesejahteraan Psikologis Lansia di Gabungan Organisasi Wanita (GOW) Kota Magelang, Jawa Tengah, skripsi, Jakarta; Program Studi Pendidikan Kesejahteraan Keluarga, Fakultas Teknik, Universitas Negeri Jakarta, 2021. Dosen Pembimbing Dr. Hamiyati, M.Si., Mulyati, M.Si.

 

Penelitian ini bertujuan untuk mengetahui hubungan grandparenting style dengan kesejahteraan psikologis lansia di Gabungan Organisasi Wanita (GOW) Kota Magelang, Jawa Tengah. Pengumpulan data pada bulan Januari 2020 dengan metode survei dengan pendekatan korelasional. Populasi pada penelitian ini adalah lansia yang berusia 64-74 tahun dengan jumlah sampel sebanyak 54 responden yang terdiri dari lansia wanita (nenek). Penentuan sampel pada penelitian ini menggunakan metode non probability sampling dengan teknik pengambilan data menggunakan teknik sampling jenuh. Pengumpulan data menggunakan skala Grandparenting Style (32 aitem) dan skala Kesejahteraan Psikologis (16 aitem). Uji hipotesis data yang digunakan adalah korelasi koefisien product moment. Hasil analisis data menunjukkan rhitung > rtabel yaitu sebesar (rhitung 0,452 > rtabel  0,2262). Hasil uji t dengan taraf signifikan 0,05 diperoleh thitung>ttabel yaitu (thitung 3,65 > ttabel 1,675) dapat disimpulkan bahwa terdapat hubungan yang kuat dan signifikan antara grandparenting style dengan kesejahteraan psikologis lansia.

Kata Kunci : Grandparenting Style, Kesejahteraan Psikologis, Lansia
Developing the First Iranian Guideline for Management of Poor Prognosis Infants
Authors: Nayeri Fatemeh Sadat , Asghari Fariba , Arani Mahmoud Motevasel , Vigeh Mohsen , Kheyri Maryam , Shamsi-Gooshki Ehsan , Parsapoor Alireza , Shariat Mamak , Farrokhzad Nahid
Published: November 2021

Background: Significantly improvements in the medical science and advanced in medical equipment and hospital facilities have increased the survival rate of poor prognosis infants (PPIs), including premature/extremely low birth weight, asphyxiated, and born with potentially lethal congenital disorders. However, availability of medical resources was not at the same levels across Iran’s cities. Thus, the country health care system encounters to a challenging question about providing advanced care to PPIs. Methods: The present study aimed to develop a national guideline for management of PPIs. We reviewed 120 articles, protocols, and guidelines, and held 15 sessions with 42 active participants. Semi-structured interviews were performed separately with medical specialist teams, medical ethicists, religious masters (Shia clerics), and parents of PPIs. Results & Conclusions: This guideline is the first nationwide attempt to prepare a comprehensive framework that can support prenatal counseling in Iranian hospitals with various medical facilities to achieve more homogeneity in newborn medical care. In addition, we collected an extensive list of lethal congenital malformations, genetic disorders, inborn errors of metabolism and covers the main areas of concern with a clearly states of responsibilities for decision-making regarding prenatal counseling for PPIs across Iran.
Isolated central nervous system relapses in patients with high-risk neuroblastoma. Clinical presentation and prognosis: experience of the Polish Pediatric Solid Tumors Study Group.
Authors: Wieczorek Aleksandra , Stefanowicz Joanna , Hennig Marcin , Adamkiewicz-Drozynska Elzbieta , Stypinska Marzena , Dembowska-Baginska Bozenna , Gamrot Zuzanna , Woszczyk Mariola , Geisler Julia , Szczepanski Tomasz , Skoczen Szymon , Ussowicz Marek , Pogorzala Monika , Janczar Szymon , Balwierz Walentyna
Published: November 2021

Although isolated central nervous system (CNS) relapses are rare, they may become a serious clinical problem in intensively treated patients with high-risk neuroblastoma (NBL). The aim of the study is presentation, assessment of incidence and the clinical course of isolated CNS relapses. Retrospective analysis involved 848 NBL patients treated from 2001 to 2019 at 8 centers of the Polish Pediatric Solid Tumors Study Group (PPSTSG). Group characteristics at diagnosis, treatment and patterns of relapse were analyzed. Observation was completed in December 2020. We analyzed 286 high risk patients, including 16 infants. Isolated CNS relapse, defined as presence of a tumor in brain parenchyma or leptomeningeal involvement, was found in 13 patients (4.5%, 8.4% of all relapses), all of them were stage 4 at diagnosis. Isolated CNS relapses seem to be more common in young patients with stage 4 MYCN amplified NBL, and in this group they may occur early during the first line therapy. The only or the first one symptom may be bleeding into CNS, especially in younger children, even without clear relapse picture on imaging, or the relapse may be clinically asymptomatic and found on routine screening. Although incidence of isolated CNS relapses is not statistically significantly higher in patients after immunotherapy, their occurrence should be carefully monitored, especially in intensively treated infants, with potential disruption of brain-blood barrier.
Patient Mistreatment of Health Care Providers
Authors: Mahoney David A , Gopisetty Divya , Osterberg Lars , Nudel Matthew JR , Smith-Coggins Rebecca
Published: November 2021

BackgroundMistreatment of medical professionals by patients is an ongoing problem. We aimed to construct and evaluate a curriculum that would prepare medical professionals for mistreatment by patients. MethodsLessons learned from 15 interviews and 2 focus groups with medical professionals were distilled into a multi-modal curriculum including didactics, simulation videos and role-play scenarios aimed to improve confidence in addressing mistreatment. This curriculum was disseminated at five educational workshops to medical professionals of various training groups and experience levels. Pre- and post-surveys were distributed to assess changes in participant’s perspectives on readiness to address mistreatment. The signed-rank test was implemented to compare pre- and post- data. ResultsParticipants were more likely to agree post-workshop that they had the right words to say, had a plan for what to do, and were more willing to speak up when they themselves or someone else was mistreated (p < .001). They were also more likely to agree post-workshop that there was something they could do to address patient mistreatment (p < .001).ConclusionsParticipant familiarity and confidence in responding to patient mistreatment increased. Our curriculum may serve as a foundation for institutions seeking to equip their educators, providers, and trainees with strategies for addressing this important issue.
Frontal Neurenteric Cysts Combined with Anterior Skull Base Osteoma and Spontaneous Intracranial Pneumatosis：A Case Report and Literature Review
Authors: Wu Yuekui , Pan Xin , Yan Pengxiang , Zhang Yuqi , Sun Yanhui , Cui Jian
Published: November 2021

Background: Neurenteric cysts (NCs) are rarely that arise from incomplete dissolution of the neurenteric canal,most are found in the spinal canal, intracranial neurenteric cysts occur rarely,no cases of neurenteric cysts combined with anterior skull base osteoma have been reported.Case presentation: A 23-year-old man presented with intermittent headache and vomiting for more than 20 days after running.The computed tomography(CT) and magnetic resonance imaging(MRI) showed a cystic mass and bone tumor in the left frontal lobe, accompanied by intracranial pneumatosis in the left ventricle and left frontal lobe,then he underwent a bicoronal scalp incision and frontal craniotomy to perform resection of the lesion. Postoperative cranial MRI showed no residual tumor. The patient recovered well after surgery, without ambulation or neurological complications.Conclusions: Based on existing literature and this case, we suggest that surgical resection of intracranial neurenteric cysts should be the first choice, and the accompanying intracranial osteoma is removed at the same time. The treatment of choice remains complete surgical excision, and prognosis is good.
Prevention of Incisional Hernia in Ovarian Cancer Patients Undergoing Midline Laparotomy
Authors: Capdevila Berta Fabregó , Miralpeix Ester , Solé-Sedeño Josep-Maria , Pereira José-Antonio , Mancebo Gemma
Published: November 2021

BACKGROUND: Incisional hernias (IH) are a frequent complication of midline laparotomies in abdominal surgery. This study was conducted in order to determine the efficacy of mesh placement and assess the optimal fascia closure technique to reduce the IH rate in patients surgically treated after being diagnosed with malignant or borderline ovarian tumors.METHODS: Retrospective data from patients undergoing midline laparotomy for borderline or ovarian cancer in Hospital del Mar, Barcelona, from January 2008 to December 2019 were collected. Patient demographic, preoperative and intraoperative characteristics and risk factors for hernia were reported. The incidence of IH between groups (mesh and non-mesh) and the technique used in fascial closure for each patient (small bites technique vs large tissue bites) was reported. RESULTS: In total, 133 patients with available data for follow-up were included. After clinical and radiological examination, 25 (18.79%) of them showed IH. 18 of 61(29.5%) patients in non-mesh group developed IH, compared with 7 of 72 (9.7%) in mesh group (OR 0.25, 95% CI 0.09-0.66, p<0.005). Patients of large tissue bites group showed higher prevalence of IH compared with small bites technique group without statistical significance (OR 0.46, 95% CI 0.17-1.24, p=0.119). The combination of mesh reinforcement and small bites technique for fascial closure significantly reduce IH risk (p=0.021). CONCLUSION: Incidence of IH is high in patients undergoing midline laparotomy for ovarian cancer or borderline ovarian tumor. The addition of a prophylactic mesh and use of small bites technique may reduce the incidence of IH and potentially minimize the social impact and costs of this complication.
3d Printed Customized Total Scapular Replacement With Constrained Shoulder Joint After Wide Resection For Scapula Chondrosarcoma Treatment: A Case Report
Authors: Tran Dung Trung , Dang Quang Minh , Tran Thanh Duc , Nguyen Sang Tran Quang , Tran Cong Van
Published: November 2021

IntroductionTotal scapular replacement surgery with constrained reverse shoulder joint a complex surgery, especially in the selection of replacement materials. The advent of three-dimensional (3D) printing technique contribute significantly to the success of surgeryCase presentationA 62-year-old female patient discovered a scapular tumor at the end of 2017. She underwent curettage and bone graft surgery 3 times. The histopathological diagnosis was enchondroma. However, tumor recurrence and malignant transformation unfortunately presented later. She visited our center and total scapular replacement with constrained reverse shoulder joint was then performed. After 6 months, the patient's functional outcome was evaluated by using Musculoskeletal Tumour Society Score (MSTS) with a score of 26/30. There was no sign of local tumor recurrence. The functional of elbow and hand was preserved almost completely. The range of active movement of the shoulder was 60° for forward flexion and abduction, and 45° for backward flexion.DiscussionDespite the follow-up time was still short, the use of the constrained shoulder joint with the applications of patient-specific 3D printing showed very positive outcomes. Patient was able to start rehabilitative early without any problems. More follow-up time would be needed to evaluate the long-term effectiveness of this method.ConclusionTotal scapular replacement with constrained reverse shoulder joint using 3D printing technology is a suitable option for the patients with scapular tumor invading the muscles of the rotator cuff.
Predicting protein-protein interactions between banana and Fusarium oxysporum race 4 integrating sequence and domain homologous alignment and neural network verification
Authors: Fang Hui , Zhong Cheng , Tang Chunyan
Published: November 2021

Background: The pathogen of banana Fusarium oxysporum race 4 (Foc4) infects almost all banana species, and it is the most destructive. The molecular mechanism of the interactions between Fusarium oxysporum and banana still needs to be further investigated.Methods: We use both the homology-interolog and domain-domain method to predict the protein-protein interactions (PPIs) between banana and Foc4. The predicted protein interaction sequences are encoded by the conjoint triad and autocovariance method respectively to obtain continuous and discontinuous information of protein sequences. This information is used as the input data of the neural network model. The Long Short-Term Memory (LSTM) neural network five-fold cross-validation and independent test methods are used to verify the predicted protein interaction sequences. To further confirm the PPIs between banana and Foc4, the Go functional annotation and interaction network analysis are carried out.Results: The experimental results show that the PPIs for banana and foc4 predicted by our proposed method may interact with each other in terms of sequence structure and GO functional annotation, and Foc4 protein plays a more active role in the process of Foc4 infecting banana.Conclusions: This study obtained the PPIs between banana and Foc4 by using computing means for the first time, which will provide data support for molecular biology experiments.
Efficient Processing of Top-k Frequent Spatial Keyword Queries
Authors: Xu Tao , Xu Aopeng , Mango Joseph , Liu Pengfei , Ma Xiaqing , Zhang Lei
Published: November 2021

The rapid popularization of high-speed mobile communication technology and the continuous development of mobile network devices have given spatial textual big data (STBD) new dimensions due to their ability to record geographical objects from multiple sources and with complex attributes. Data mining from spatial textual datasets has become a meaningful study. As a popular topic for STBD, the top-k spatial keyword query has been developed in various forms to deal with different retrievals requirements. However, previous research focused mainly on indexing locational attributes and retrievals of few target attributes, and these correlations between large numbers of the textual attributes have not been fully studied and demonstrated. To further explore interrelated-knowledge in the textual attributes, this paper defines the top-k frequent spatial keyword query (tfSKQ) and proposes a novel hybrid index structure, named RCL-tree, based on the concept lattice theory. We also develop the tfSKQ algorithms to retrieve the most frequent and nearest spatial objects in STBD. One existing method and two baseline algorithms are implemented, and a series of experiments are carried out using real datasets to evaluate its performance. Results demonstrated the effectiveness and efficiency of the proposed RCL-tree in tfSKQ with the complex spatial multi keyword query conditions.
Inhibition of DNA Topoisomerases I and II and Cytotoxicity of Compounds from Polygonum aviculare L .
Authors: Yu Yue , Zheng Xue-dan , Piao Meng-hua , Wang Yi-ming , Li Gao , Jin Mei , Zheng Ming-shan
Published: November 2021

Six flavonoid glycosides ( 1 – 3 , 6 – 8 ), one lignan ( 4 ), and one galloyl glycoside ( 5 ) were isolated based on the phytochemical study for the MeOH extract of Polygonum aviculare L. herb. The eight isolated compounds' structures were determined by comparing their physicochemical and spectral data with published ones. Compounds 5 and 6 were first isolated from this plant, and all the compounds were evaluated for DNA topoisomerase inhibitory activities and cytotoxicities. Among the purified compounds, 5 showed stronger inhibitory activity against topoisomerase I with an IC 50 value of 12.0 μM, while the value of positive control camptothecin (CPT) was 17.0 μM. For compounds 1 , 3 , and 5 – 8 , the value ranged from 0.054 to 17.0 µM, suggesting more potent inhibitory activity against topoisomerase II, and that of etoposide (VP-16) was 28.0 µM. Particularly, compounds 6 and 8 (IC 50 = 0.054 and 0.077 µM, respectively) inhibited Topo II about 500 times stronger than VP-16, making them safer agents of DNA topoisomerase. Furthermore, all compounds demonstrated no cytotoxic activity against four cancer cell lines. This study is the first to report the inhibition of DNA topoisomerases of compounds from P. aviculare , suggesting that these compounds may be potential candidates for treating cancer.
A Simulation Framework for Evaluating Statistical Methods for Quality Control in Manufacturing
Authors: Fries Niklas , Rydén Patrik
Published: November 2021

Statistical methods are commonly used to monitor quality in manufacturing processes. We consider a set of problems where the probability that a unit is defect, i.e., the defect probability, is influenced by a large number of sub-processes, and where the overall aim is to monitor the defect probability and link abnormalities in quality to observed production variables. We developed a simulation framework for studying the performances of statistical methods used to solve the considered problem. Fourteen prediction procedures were obtained by combining six prediction methods (linear regression, logistic regression, LASSO, penalized logistic regression, support vector machines, gradient boosting decision trees) and two pre-processing procedures. These prediction procedures were evaluated on four types of simulated datasets with different relationships between the explanatory variables and the defect probabilities. Additionally, two established methods for variable selection were compared to a novel method called mixed moments selection (MMS). MMS was more robust than the other methods, performed well on all dataset types, and can easily be combined with any type of prediction method. Additionally, it was shown that it can be advantageous to complement the original explanatory variables with their squared values prior to analyzing the data. Overall, a procedure combining MMS, including additional quadratic terms and using PLR had the best performance. The proposed framework can be applied to evaluate any type of prediction procedure for the general problem we consider. This would increase the understanding of different procedures and facilitate the selection of procedures for a specific problem.
Association between Cognitive Impairment and Olfactory Deficits in Systemic Lupus Erythematosus Without Major Neuropsychiatric Syndromes
Authors: Xu Xue , Kong Wei , Geng Linyu , Chen Chen , Yang Hailong , Kong Wentao , Wen Baojie , Bian Wenjuan , Chen Siwen , Xu Renju , Jun Liang , Sun Lingyun
Published: November 2021

Objective Cognitive impairment is a common neuropsychiatric manifestation of systemic lupus erythematosus (SLE). However, it is not routinely assessed despite its high morbidity and mortality. The aim of the study was to investigate the utility of a brief neuropsychological battery, the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), to evaluate cognitive deficits in patients with SLE and to examine the relationship between cognitive and olfactory function. Methods Fifty-five SLE patients and 50 age- and sex-matched healthy control subjects were administered the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), a cognitive screening battery that evaluated five index of cognition including immediate memory (IMME), visuospatial/constructional (Vis/Con), language (LANG), attention (ATT), delayed memory (DEME). Olfactory functions were evaluated using olfactory function assessment by computerized testing including the three stages of smell: threshold (THR), identification (ID) and memory (ME) of the different odors. The disease activity and cumulative damage were assessed by the SLE Disease Activity Index 2000 (SLEDAI-2K) and the Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology(ACR) Damage Index (SDI). Results Patients with SLE exhibited significant lower total RBANS score, IMME, Vis/Con, ATT and DEME index scores than normal controls (P < 0.01 for all and P = 0.027 for attention). Performances on RBANS immediate memory, language, attention and total scores were correlated with education level of SLE patients. Reduced RBANS index and total scores were associated with several organ involvement and autoantibodies. SLE patients with higher SLEDAI-2K scores or with accumulated damage (SDI≥1) showed decreased RBANS scores than patients with lower SLEDAI-2K scores or without accumulated damage. All the olfactory scores (THR, ID and ME) in patients with SLE were significantly decreased than the control group (all P = 0.001). Patients had higher proportion of anosmia (8.57% vs 0%) and hyposmia (28.58% vs 5.72%) than controls (χ2 = 10.533, P = 0.015). Multivariable regression analysis revealed that olfactory threshold, identification and memory had a positive effect on RBANS index score. Olfactory memory and total score were significantly correlated with the RBANS delayed memory (r = 0.393, P = 0.021) and total scores (r = 0.429, P = 0.011).Conclusion The results of this study indicate that significantly correlated cognitive and olfactory functions are impaired in SLE patients. The RBANS is a potentially useful instrument for evaluating neuropsychological status in SLE. Physicians are encouraged to perform routine screening in patients with SLE to detect subtle cognitive dysfunction and strategize early treatment options.
Trauma and sinusitis induce orbital cellulitis in an 11-year-old boy
Authors: Liang Cong , Zheng Ru-Jiang , Li Su-Ping , Li Yi-Juan , Xu Ling-Ling
Published: November 2021

Background

We conducted a literature review and found that the most common causes of orbital cellulitis susceptibility in children are infections in adjacent areas (such as sinusitis, dental disease, upper respiratory tract infections, and facial skin infections), recent trauma/surgery, foreign bodies, and insect bites. This article aims to discuss the differential diagnosis and treatment of orbital cellulitis in children.
Case presentation:

Here we present a report of a case of orbital cellulitis with intra-frame abscess induced by trauma and sinusitis, and a review of the relevant literature. An 11-year-old boy with a history of orbital trauma one year earlier had had fever, pain in the right eye, periorbital swelling, restricted extraocular movement, protruding eyes, and decreased vision for six days before admission. The initial treatment with intravenous Rocephin and linezolid was unsuccessful. MRI showed sinusitis and orbital abscess. Endoscopic sinus surgery was then performed to clean up the purulent secretions in the orbit, which relieved his orbital symptoms.
Conclusions

Here, we report a case of sinusitis and trauma-induced orbital cellulitis in an 11-year-old boy. The use of intravenous antibiotics and further treatment with orbital incision and decompression led to clinical improvement. Children with orbital complications of acute sinusitis have complex clinical manifestations and rapid disease progression. Our literature review findings suggest that broad-spectrum antibiotics are the main empirical treatment, and abscesses are not an absolute indication for immediate surgery. Therefore, dynamic evaluation, multidisciplinary consultations, and surgical treatment (if necessary) should be performed in cases of orbital cellulitis.
Parental Oral Hygiene Knowledge: Investigating the Source for Successful Oral Hygiene Behavior in Children
Authors: Moore Ed.D. Wallace
Published: November 2021

Background

The deleterious effects of dental caries in children can often be arrested if parents are knowledgeable regarding dental treatment. The purpose of this study was to examine the relationship between a parent’s level of oral hygiene knowledge and the oral hygiene behaviors of their children ages 7 to 17 in the greater United States.
Methods

The researcher utilized a quantitative descriptive study based on a non-experimental cross-sectional survey design. 103 participants voluntarily responded. To be eligible, participants had to live in the greater United States and have a child between the ages of 7 to 17.
Results

Data analysis was completed using inferential statistics while utilizing the chi-square test of independence as the analytical method. The Chi-Square test was used to determine whether a relationship between the parent’s hygiene knowledge and the child’s oral hygiene behaviors existed. Results did reveal an association between the variables, a parent’s hygiene knowledge and their child’s oral health hygiene behaviors upon completion of the chi-square test analysis.
Conclusions

The oral hygiene knowledge of some parents needs to be increased to ensure positive outcomes with their child’s oral hygiene behaviors—information about pit and fissure sealants to aid in the prevention of dental caries for their children would be highly advantageous. Additionally, further studies are warranted to address possible limitations of the child and parental socioeconomic issues.
Post-COVID-19 illness trajectory: a multisystem investigation.
Authors: Berry Colin , Morrow Andrew , Sykes Robert , McIntosh Alasdair , Kamdar Anna , Bagot Catherine , Barrientos Pauline , Bayes Hannah , Blyth Kevin , Briscoe Michael , Bulluck Heerajnarain , Carrick David , Church Colin , Corcoran David , Findlay Iain , Gibson Vivienne , Gillespie Lynsey , Grieve Douglas , Ho Antonia , Lang Ninian , Lowe David , Lennie Vera , Macfarlane Peter , Mayne Kaitlin , Mark Patrick , McConnachie Alex , McGeoch Ross , Mcginley Christopher , McKee Connor , Nordin Sabrina , Payne Alexander , Rankin Alastair , Ryan Nicola , Roditi Giles , Stobo David , Sattar Naveed , Allwood-Spiers Sarah , Touyz Rhian , Veldtman Gruschen , Weeden Sarah , Watkins Stuart , Welsh Paul , Wereski Ryan , Mangion Kenneth
Published: November 2021

Background: The pathophysiology and trajectory of multiorgan involvement in post-COVID-19 syndrome is uncertain. Methods: A prospective, multicenter, longitudinal, cohort study involving post-COVID-19 patients enrolled in-hospital or early post-discharge (visit 1) and re-evaluated 28-60 days post-discharge (visit 2). Multisystem investigations included chest computed tomography with pulmonary and coronary angiography, cardiovascular and renal magnetic resonance imaging, digital electrocardiography, and multisystem biomarkers. The primary outcome was the adjudicated likelihood of myocarditis.Results: 161 patients (mean age 55 years, 43% female) and 27 controls with similar age, sex, ethnicity, and vascular risk factors were enrolled from 22 May 2020 to 2 July 2021 and had a primary outcome evaluation. Compared to controls, at 28-60 days post-discharge, patients with COVID-19 had persisting evidence of cardio-renal involvement, systemic inflammation, and hemostasis pathway activation. Myocarditis was adjudicated as being not likely (n=17; 10%), unlikely (n=56; 35%), probable (n=67; 42%) or very likely (n=21; 13%). Acute kidney injury (odds ratio, 95% confidence interval: 3.40 (1.13, 11.84); p=0.038) and low hemoglobin A1c (0.26 (0.07, 0.87); p=0.035) were multivariable associates of adjudicated myocarditis. During convalescence, compared to controls, COVID-19 was associated with worse health-related quality of life (EQ5D-5L) (p<0.001), illness perception (p<0.001), anxiety and depression (p<0.001), physical activity (p<0.001) and predicted maximal oxygen utilization (ml/kg/min) (p<0.001). These measures were associated with adjudicated myocarditis.Conclusions: The illness trajectory of COVID-19 includes persisting cardio-renal inflammation, lung damage and hemostasis activation. Adjudicated myocarditis occurred in one in eight hospitalized patients and was associated with impairments in health status, physical and psychological wellbeing during community convalescence. Public registration: ClinicalTrials.gov identifier is NCT04403607.
Identification of biomarkers and signaling pathways during the treatment of multiple myeloma
Authors: Gu Hanming
Published: November 2021

Multiple myeloma (MM) is an incurable hematologic malignancy, which is characterized by increased bone marrow plasma cells, osteolytic lesions, and anemia. Here, our aim is to characterize significant biomarkers and signaling pathways during the treatment of MM by using bioinformatic methods. The GSE180018 dataset was generated by DNBSEQ-G400 (Homo sapiens). The KEGG and GO analyses showed the biological processes such as " Protein export”, “Protein processing in endoplasmic reticulum”, “Vibrio cholerae infection”, “Fc gamma R-mediated phagocytosis" are mainly affected in FOXM1 KO MM cells. Moreover, we identified the significant genes including CD44, NOTCH1, SELL, RAC2, HSPA8, VAV1, DDIT3, PLK1, HYOU1, ITGAL in FOXM1 KO MM cells. Therefore, our study may provide further guidance for the drug development of MM.
Sharing cities with avian scavengers: sustainable development in social-ecological systems
Authors: Gupta Urvi , Kumar Nishant
Published: November 2021

Correlations in the timings of vulture collapse and rapid urbanisation in South Asia have affected the benefit trade-offs concerning conservation-breeding for vulture restoration. We show how the loss of vultures 30 years ago has led to the extinction of experience amongst people in South Asia who are co-adapted to various animal species within shared landscapes. We conducted ethnography that focused on avian scavengers (vultures, kites and crows) in Delhi to unpack how salience and charisma for avian scavengers link with socio-cultural legends. Perceptions about avian scavengers were based on birds’ appearance, behaviour, and ecosystem services. Anthropomorphisation mediated human-animal co-adaptation and drove ritual feeding of commensals that opportunistically consume garbage. Conflated with ethnoecology, such human-constructed niches supported enormous animal populations in the region and drove mutual tolerance. Prior evaluations of scavengers’ niche from biophysical perspectives alone have, therefore, overlooked links between vultures and animal husbandry practices. It undermined competitive release on commensals that have responded by an increase in numbers and distribution, by taking advantage of ritual feeding and people’s affiliative attitudes. The absence of vultures limits the availability of spaces where animal husbandry can be practised. Conversely, expanding built-up spaces, overhead wires, fake news, and interference from competing scavengers will be impediments to vulture restoration. Conservation policies should examine immediate and long-term objectives of solid waste disposal, considering the odds against the attainment of the yesteryear functional ecology of vultures in South Asia. We conclude that wildlife restoration in urbanising tropical landscapes is a moving target, necessitating policies sensitive to progressive loss and/or changes in associative heritage due to shifting economic and cultural practices.
WITHDRAWN: Effects of Various Decolorizing Agents on Waste Cotton Fabric Dyed with Reactive Dyes
Authors: Li Ruojia , Yang Jianjun , Hu Jiewen , Zhang Gangqiang , Zhu Ping
Published: November 2021

Shorter fashion cycles have led to the rapid accumulation of unwanted and waste textiles. Compared to light-coloured textiles, the dark-coloured ones are more difficult to recycle and reuse, and their incineration and landfilling have negative environmental consequences. A technology that sufficiently decolorizes these textiles without causing major damage to their structure and properties is therefore useful. In this study, a waste cotton fabric containing vinyl sulfone reactive dyes was subjected to chemical treatments with different oxidants and/or reducing agent. The effects of various treatments on the fabric’s coloration and mechanical properties were compared. The two-step treatment using first Na2S2O4 and then H2O2 showed the best performance, achieving a CIE whiteness index of 65.1, 19.3% tensile strength loss, 1.8% weight loss, 93.5% decolouration rate, and a degree of polymerization of 747.7. A mechanism was proposed to explain the synergistic decolorization process.
Amelioration of depressive symptoms on Fawn-Hooded rats through the 'healthy' fecal microbiota transplantation
Authors: Hu Bing , Das Promi , Lv Xianglin , Shi Meng , Aa Jiye , Wang Kun , Duan Liping , Gilbert Jack A , Nie Yong , Wu Xiao-Lei
Published: November 2021

Background : Depression is a recurrent, heterogeneous mood disorder, occurring in more than 260 million people worldwide. Gut microbiome dysbiosis is associated with the development of depressive-like behaviors by modulating neuro-biochemical metabolism through the microbiome-gut-brain (MGB) axis. Fecal microbiota transplantation (FMT) has been proposed as a potential therapeutic solution for depression, but the therapeutic efficiency and mechanism is unknown. Results : We performed FMT from Sprague-Dawley (SD) rats ('healthy' controls) to Fawn-hooded (FH) rats (depression model). Pre-FMT, the FH rats exhibited significantly elevated depressive behaviors and distinct neurotransmitter and cytokine levels compared with SD rats. Post-FMT, FH recipients receiving SD microbiota showed reduced depressive behaviors, a significant increase in hippocampal neurotransmitters and a significant decrease of some hippocampal cytokines compared to the ones receiving FH microbiota. SD-FMT resulted in the FH recipients' gut microbiome resembling the SD donor, and a significant shift in the serum metabolome but not the hippocampal metabolome. Conclusions : SD-FMT was inferred to ameliorate recipients' physiochemical features of depression via the significant decrease of gut microbial species such as Dialister sp., which led to the recipients' metabolic modulation in serum and hippocampus through the enteric nervous system, the intestinal barrier and the blood-brain barrier. Our results provided new data pointing to multiple mechanisms of interaction for the impact of gut microbiome modulation on depression therapy.
Managing Neurosurgery in the Covid-19 Pandemic
Authors: Aminmansour Bahram , Mahmoudkhani Mehdi , Shafiei Mehdi , Sabouri Masih , Hematzadeh Mehrnaz , Tehrani Donya Shaybeni
Published: November 2021

BackgroundCovid-19 quickly spread around the world as an epidemic with potentially unknown hazards. Like its impacts on various occupations, neurosurgery has undergone changes due to the virus, including changes in surgical planning, inpatient and outpatient clinics, emergency management, and even academic activities. The present study was performed to determine neurosurgery challenges during the Covid-19 pandemic in Iran.MethodsThe present study was conducted as a mixed qualitative and quantitative study in 2021. In the qualitative section using the targeted sampling method, 11 members of the target community were selected using the available sampling method and completed a questionnaire. The qualitative part was conducted in two stages of reviewing texts and interviewing experts and in the quantitative part we evaluated the validity of the structure and the reliability of the questionnaire.ResultsThis study examined in detail all aspects of the effects of Covid-19 on neurosurgery. 9 dimensions and 61 items were identified as the challenges of neurosurgery during the Covid-19 pandemic. In order of importance, the aspects were: treatment outcome, manpower, management psychological and physical diseases, education and research, tools and physical space, ethics, financial implications and information technology.Conclusion﻿The outbreak of epidemics has different risks for specialties, among them neurosurgery. Accordingly, to observe patients' right to treatment, all necessary measures were first taken to provide instructions, regulations, policies and ethical guidelines.
Glitch in Contemporary Video Art (Iranian Glitch Artists)
Authors: Karimi Nazila
Published: November 2021

Glitch art is the use of digital or analog errors for cosmetic purposes by corrupting digital data or physical manipulation of electronic devices. What's called "glitch art" usually means visual bugs, whether in a still or moving image. It is difficult to classify and recognize a glitch. Primarily from a theoretical, scientific and non-artistic perspective, Glitch is the unexpected result of a malfunction. This artistic genre has influenced the art of video and has led to the interest of many video artists in this art genre, in this research, the works of video glitch of Iranian artists have been investigated and the techniques employed by the artist are described. In this regard, 6 samples of the works of different Iranian video glitch artists were selected and examined. According to the study, it can be concluded that Iranian video art artists have used this artistic genre in their works to express their intention and purpose.
The Fate of Indeterminate Liver Lesions: What Proportion Are Precursors of Hepatocellular Carcinoma? A Retrospective Follow-up Study
Authors: Cococcia Sara , Dutta Priti , Moghim Melika , Hogan Brian , Tanwar Sudeep , Marshall Aileen , Macdonald Douglas , Yu Dominic , O’Beirne James , Rosenberg William M , Trembling Paul M
Published: November 2021

BackgroundThe natural history and incidence of hepatocellular carcinoma (HCC) arising from indeterminate liver lesions is not well characterised. We aimed to define the incidence of HCC in a cohort of patients undergoing surveillance by magnetic resonance imaging (MRI) and estimate any associations with incident HCC.MethodsWe performed a retrospective follow-up study, identifying MRI scans in which indeterminate lesions had been reported between January 2006 and January 2017. Subsequent MRI scan reports were reviewed for incident HCC arising from indeterminate lesions, data were extracted from electronic patient records and survival analysis performed to estimate associations with baseline factors.ResultsOne hundred and nine patients with indeterminate lesions on MRI were identified. HCC developed in 19 (17%) patients over mean follow up of 4.6 years. Univariate Cox proportional hazards analysis found incident HCC to be significantly associated with baseline low platelet count (hazard ratio (HR) = 7.3 (95% confidence intervals (CI); 2.1 – 24.9), high serum alpha-fetoprotein level (HR = 2.7 (95% CI; 1.0 – 7.1)) and alcohol consumption above fourteen units weekly (HR = 3.1 (95% CI; 1.1 – 8.7)). Multivariate analysis, however, found that only low platelet count was independently associated with HCC (HR = 5.5 (95% CI; 0.6 – 5.1)).ConclusionsHCC arises in approximately one fifth of indeterminate liver lesions over 4.6 years and is associated with a low platelet count at the time of first diagnosis of an indeterminate lesion. Our data support a strategy of enhanced surveillance in patients with indeterminate lesions.
Risk Factors of Elevated Blood Ammonia Level in Epilepsy Patients Treated With Lamotrigine
Authors: Chen Yiqian , Chen Jingzhen , Zhuang Xiaorong , Chen Xingyu , Zeng Jianqi , Wang Ru , Miao Jiayin
Published: November 2021

Background
The aim of this study was to explore the effect of lamotrigine (LTG) on blood ammonia level in patients with epilepsy and identify risk factors affecting blood ammonia level.
Methods
This study included 91 epilepsy patients who were treated with LTG at Department of Neurology, Zhongshan Hospital, Xiamen University from January 2011 to April 2016, and were followed up for three years. Blood samples were taken during the interictal state and analyzed for blood LTG and ammonia levels.
Results
Total 46.1% of the samples exceeded the median blood ammonia level, and 2.1% of patients had hyperammonemia. Blood ammonia level was positively correlated with LTG blood concentration. LTG combined with valproic acid (VPA) therapy, seizure within one year, and elevated neutrophils affected blood ammonia level.
Conclusion
Blood ammonia level was significantly correlated with plasma concentration of LTG. LTG combined with VPA therapy, seizure within one year, and elevated neutrophils may be risk factors for elevated blood ammonia level in epilepsy patients treated with LTG.
Acute kidney injury after liver resection: A systematic review, meta-analysis and metaregression of factors affecting it
Authors: vasavada bhavin bhuendra , patel hardik
Published: November 2021

AimThis systematic review and meta-analysis aimed to study the incidence of acute kidney injury after liver resection and to analyze various factors affecting it by metaregression analysis.MethodsThe study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (2020) and MOOSE guidelines. The meta-analysis was done using Review Manager 5.4 and the JASP Team (2020). JASP (Version 0.14.1)(University of Amsterdam). Weighted percentage incidence with 95% confidence intervals were used. Univariate metaregression was done by DerSimonian-Laird methods. Factors with a p-value less than 0.05 in the univariate metaregression model were entered in the multivariate metaregression model. Heterogeneity was assessed using the Higgins I2 test. The random-effects model was used in meta-analysis.ResultsTotal 14 studies including 15510 patients were included in the final analysis. 1247 patients developed Acute Kidney Injury. Weighted Acute kidney injury percentage after liver resection was 15% with a 95% confidence interval of 11%-19%. On univariate metaregression analysis major hepatectomy (p=0.001), Underlying cirrhosis of liver (p=0.031), AKIN definition used (0.017), male sex (p<0.001), open surgery (p=0.032), underlying diabetes (0.026). On multivariate metaregression analysis major hepatectomy (p=0.003), underlying cirrhosis (p<0.001), male sex (p<0.001), AKIN classification used for defining acute kidney injury (p < 0.001, independently predicted heterogeneity and hence acute kidney injury.ConclusionLiver resection is associated with a high incidence of acute kidney injury. Major hepatectomy, male sex, underlying cirrhosis were independently predicting acute kidney injury.
Circ-CTNNB1 Drives Aerobic Glycolysis and Osteosarcoma Progression via m6A Modification Through Interacting With RBM15
Authors: Liu Hucheng , Xiao Jun , Li Bo , Chen Yajun , Zeng Jin , Hu Anpei , Zhou Song , Liu Yangyang , Yang Feng
Published: November 2021

Background

In a previous study, we have identified that circ-CTNNB1 (a circular RNA derived from CTNNB1) drives cancer progression through the activation of the Wnt/β-catenin signaling pathway in various tumors. However, the functions of circ-CTNNB1 in regulating osteosarcoma (OS, a highly malignant bone tumor in children and adolescents) remain unclear. In this study, we aimed to assess the role of circ-CTNNB1 in OS and identify the underlying mechanisms, which may contribute to the exploration of a potential therapeutic strategy for OS.
Methods

Circ-CTNNB1 was analyzed by qRT-PCR, and the results were confirmed by Sanger sequencing. The interaction and effects between circ-CTNNB1 and RNA binding motif protein 15 (RBM15) were analyzed through biotin-labeled RNA pull-down and mass spectrometry, in vitro binding, and RNA electrophoretic mobility shift assays. In vitro and in vivo experiments were performed to evaluate the biological functions and underlying mechanisms of circ-CTNNB1 and RBM15 in OS cells.
Results

Circ-CTNNB1 was highly expressed in OS tissues and predominantly detected in the nucleus of OS cells. Ectopic expression of circ-CTNNB1 promoted the growth, invasion, and metastasis of OS cells in vitro and in vivo. Mechanistically, circ-CTNNB1 interacted with RBM15 and subsequently promoted the expression of hexokinase 2 (HK2), glucose-6-phosphate isomerase (GPI), and phosphoglycerate kinase 1 (PGK1) through N6-methyladenosine (m6A) modification to facilitate the glycolysis process and activate OS progression.
Conclusions

These results indicate that oncogenic circ-CTNNB1 drives aerobic glycolysis and OS progression by facilitating RBM15-mediated m6A modification.
Influence of Surface Roughness on Shear Behaviours of Rock Joints Under Constant Normal Load and Stiffness Boundary Conditions
Authors: Han Guansheng , Zhou Yu , Liu Richeng , Tang Qiongqiong , Wang Xingkai , Song Leibo
Published: November 2021

The present study experimentally investigated the shear behaviors of artificial rock samples containing single or double joints under constant normal load (CNL) and constant normal stiffness (CNS) boundary conditions. The influence of surface roughness represented by joint roughness coefficient (JRC) on the evolutions of shear stress, normal stress, and normal displacement as well as the failure mode are analyzed and discussed. The results show that the peak shear stress and peak normal displacement are increased by 104% and 45.1% for single-joint specimens, which are increased by 50.1% and 182.8% for double-joint specimens when JRC ranges from 3.21 to 12.16 under CNL boundary conditions. Under a CNS boundary condition, the shear stress for single-joint and double-joint specimens increase slowly with the increase in shear displacement, and no obvious peak value is observed. However, the shear stress of double-joint specimen is lower than that of single-joint specimen due to that the former has a more complex joint structure. The surface damage degree of the upper joint is larger than that of the lower joint, and the surface failure of the lower joint lags behind that of the upper joint.
Molecular Targeting of Nrf2 and NFkB Signaling by 3-Acetyl-11-Keto- β -Boswellic Acid and Piperine Against Fluid Percussion Rat Model of Traumatic Brain Injury
Authors: Kundu Satyabrata , Singh Shamsher
Published: November 2021

Traumatic brain injury in rats through lateral fluid percussion injury (LFPI) model causes elevation of intracranial pressure which leads to impairment in motor and cognitive behaviour. 3-acetyl-11-keto-β-boswellic acid (AKBA) is a well-known anti-inflammatory agent but it has very low bioavailability. The current study was established to investigate the neuroprotective effect of AKBA in combination with bioenhancer piperine in LFPI induced TBI in experimental rats. Fluid percussion injury was introduced in the brain by delivering 50 mmHg of pressure for 3 minutes to the exposed brain. AKBA 25 mg/kg and 50 mg/kg orally and AKBA ((25 mg/kg, p.o.) in combination with piperine (2.5 mg/kg, p.o.) was administered from day 1 to day 14. On the 1st, 7th and 14th day, behavioural parameters were checked. On the 15th day, animals were euthanized. Then the cortex was isolated for the estimation of biochemical levels (MDA, nitrite, reduced GSH, catalase), neuroinflammatory markers (TNF-α, IL-1β, IL-6), and neurotransmitters (norepinephrine, dopamine, 5-HT, GABA, glutamate). From animals, hippocampus and cortex were isolated for histopathological analysis, and expressions of Nrf2 and NFkB were measured by the immunohistological study. Treatment with AKBA significantly attenuated LFPI induced abnormalities, biochemical and neurotransmitter changes in experimental rats. Further finding AKBA in combination with piperine significantly prevented histopathological changes, increased Nrf2 positive cells and reduced NFkB expression in the cortical region. The present study concluded that AKBA along with piperine achieved anti-oxidant, anti-inflammatory, neuro-modulatory effects as well as prevented neuronal injury via targeting Nrf2 and NFkB.
Automatic determination of the dual system width of to a bivalent system
Authors: Paul Vasiliu
Published: November 2021

A system is a set of elements that can be found in one of the following states: operating state and fault. Any system has two stable states: functioning and defect, which is why, in the theory of reliability, it is called a bivalent system. A subset of defective elements is called the system cut if all the other elements of the system are in operation and the system is defective. The width of a bivalent system is equal to the minimum number of elements the system cuts have. In this paper is presented an algorithm for automatic determination of the dual system width to a bivalent system, a Matlab script that implements the algorithm, a case study and subsequent directions of development.