bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving critical thinking among college students Qualitative meta-analysis of media literacy education
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Ye-Seul , You Yeong-Mahn
Published: October 2023

Objectives This study focused on critical thinking on the effects of media literacy education in universities and sought to find out the implications of this.
Methods A qualitative meta-analysis method was used based on studies on subjects related to media literacy opened in universities. Therefore, the future direction of education was considered through the positive effects and complementary points of the educational method for improving critical thinking, focusing on the cases of 6 qualitative research subjects finally selected according to the 7th stage of the analysis procedure.
Results While the sharing of various opinions under the guidance of the instructor was very helpful in cultivating a critical mind, most of the learners found it difficult to lead learning activities voluntarily due to the nature of the discussion. In addition, it was found that it was important to select the latest issues or related media in a timely manner, but the lack of concentration in class was revealed as a problem due to unreliable data exposure and irra-tionality that could occur due to bias. Above all, considering that writing education for critical thinking has hardly been dealt with except for Part 1, it can be seen that it is urgent to prepare a plan to activate writing.
Conclusions In this study, through a qualitative meta-analysis of media literacy education for the improvement of college students' critical thinking, positive effects and complementary points of discussion, media analysis, video platform, and critical writing were derived. The implications of this include development of convergence ed-ucational contents, design of critical thinking process, and development of evaluation tools. Even though the Ministry of Education and the field of education are currently emphasizing the importance of media literacy educa-tion, universities still lack systematic programs. In the future, it is expected that media literacy education for learn-ers will be activated in various major subjects through collaboration between universities and instructors.
A Meta-Analysis of Variables related to Clinical Practice Stress in Korean Nursing Students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Jung You-Hee , Yang Seung Hee
Published: October 2023

Objectives The purpose of this study was to conduct a meta-analysis on variables related to clinical practice stress among Korean nursing students and to find out the effect size of protective and risk variables.
Methods Literature selection was conducted according to the PRISMA guidelines, and RISS, DBpia, KISS, KCI, ScienceON, NAL, CINAHL, and PubMed were used to search for literature related to clinical practice stress in Korean nursing students. For meta-analysis, CMA Software version 4.0 was used. Through 161 literatures pub-lished by June 18, 2023, the effect size of the correlation between clinical practice stress and related variables of nursing students was calculated.
Results The variables related to clinical practice stress in Korean nursing students were divided into protective variables and risk variables, and then further subdivided into psychological characteristics and academic charac-teristics to confirm the summary effect size. The overall summary effect size of the protective variables group was ESr=-.159, psychological characteristics area ESr=-.135, and academic characteristics area ESr=-.193, which were medium effect sizes. As for the risk variable group was ESr=.321, psychological characteristics area ESr=.285, and academic characteristics area ESr=.393, which were medium effect sizes.
Conclusions Based on the results of this study, it is expected that clinical practice stress management programs for nursing students that can reduce risk factors while strengthening protective variables will be developed.
A Validation Study of the Korean Version of the Traumatic Grief Inventory Self-Report Plus (K-TGI-SR+)
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Seo Min-Jae , Park Kee-Hwan
Published: October 2023

Objectives This study was conducted to find out the validity and reliability of the Korean version of the Traumatic Grieve Inventory Self-Report (K-TGI-SR+).
Methods An online survey was conducted on 448 people who have lost a loved one and after dividing them into two samples by random sampling, one sample was used for exploratory factor analysis and the other for con-firmatory factor analysis. After that, internal consistency, concurrent validity, and group discrimination validity were confirmed.
Results As a result of exploratory factor analysis, two factors were found to be suitable, and two out of a total of 22 questions were eliminated because they did not meet any factors. In the confirmatory factor analysis con-ducted with 20 questions, two factors were found to be the most appropriate. Accordingly, the first factor was named “separation distress” and the second factor was named “adaptation difficulties”. In addition, high internal consistency was confirmed, and as a result of confirming the concurrent validity and group discrimination validity, it was found to have a high level of external validity.
Conclusions It has been proven that K-TGI-SR+ is a valid and reliable tool. Finally, the significance, limitations, and supplements of this study were discussed.
The Role of Chrysoperla carnea (Steph.) and Beauveria bassina for Controlling Cabbage Aphid, Brevicoryne brassicae L. on Cabbage Plants
Authors:   Plant Protection Research Institute, Agriculture Research Center, Giza, Egypt, Saleh Ahmad A.A. , El-Nagar H. ,   Plant Protection Research Institute, Agriculture Research Center, Giza, Egypt, Khalifa Amany A. ,   Plant Protection Research Institute, Agriculture Research Center, Giza, Egypt, Zawrah Mohamed F.M. ,   Faculty of Desert and Environmental Agriculture, Fuka, Matrouh University, Egypt
Published: October 2023

Saleh, A.A.A., H. El-Nagar, A.A. Khalifa and M.F.M. Zawrah. 2023. The Role of Chrysoperla carnea (Steph.) and Beauveria bassina for Controlling Cabbage Aphid, Brevicoryne brassicae L. on Cabbage Plants. Arab Journal of Plant Protection, 41(3): 321-326. https://doi.org/10.22268/AJPP-041.3.321326 Field experiments were carried out at Kafr Saqr district, Sharkia governorate during 2019/2020 and 2020/2021 growing seasons to evaluate the predator:prey ratios for the release of C. carnea and evaluation of using Beauveria bassiana suspension against the cabbage aphid, Brevicoryne brassicae. The results obtained showed that the effective control of B. brassicae was achieved ten days after releasing the larvae of the predator C. carnea when the predator:prey ratios were 1:5 and 1:10. Meanwhile, at higher ratios (1:20, 1:25 and 1:50), the cabbage aphid B. brassicae numbers decreased 25 days after predator release. The numbers of B. brassicae decreased by 84.69 and 81.61% at 1:5 and 1:10 predator:prey ratio during the first season, respectively. On the other hand, the aphid numbers were reduced by 81.50 and 70.95% at 5 days after the predator’s release during the second season, for the two predator:prey ratios, respectively. Complete reduction of B. brassicae populations was achieved at 15 days after yhe release of C. carnea larvae with predator ratios of 1:5, 1:10 and 1:15, and numbers of B. brassicae at these ratios depressed completely 20 days after release. The results revealed that the best control of B. brassicae populations under greenhouses conditions was achieved by using the lower predator:prey ratio of 1:5 and 1:10 ten days after releasing larvae of C. carnea. The highest mortality rate in B. brassicae population caused by the fungus B. bassiana was 88.33%, recorded at 7 days after the application of spore concentration 1×107 spores/ml and the LC50 obtained in the field was 1.10×106 spores/ml. It can be concluded from this study that C. Carnea and B. bassiana are effective biocontrol agents in controlling the cabbage aphid B. brassicae in the field. Keywords: B. brassicae, Chrysoperla carnea, Beauveria bassiana, Predator release.
Analisis Penerapan Excellent Service Front Office untuk Meningkatkan Kepuasan Pelanggan
Authors: Damayanthy Komang Mira , Susanti Luh Eka
Published: October 2023

Penelitian ini berfokus pada penerapan excellent service yang berlandaskan atau berpedoman pada standar operasional prosedur dengan melihat keadaan operasional yang berlangsung dalam periode yang ditentukan. Tujuan dari penelitian ini adalah untuk mengetahui penerapan excellent service oleh front office untuk meningkatkan kepuasan dan mengetahui tingkat kepuasan tamu terhadap pelayanan dengan menerapkan excellent service untuk mengetahui seberapa efektif excellent service diterapkan dalam standar operasional prosedur. Penelitian ini menggunakan metode deskriptif kualitatif dengan membandingkan nilai presentase untuk menentukan selisih dari setiap indikator dalam standar operasional prosedur yang berlaku, sehingga dapat dilakukan penyajian data untuk menarik kesimpulan. Metode pengumpulan data dalam penelitian ini adalah observasi, wawancara, dokumentasi, dan reduksi data menggunakan kuesioner. Hasil penelitian ini menunjukkan bahwa semua karyawan front office di The Wakanda Ubud sudah menerapkan excellent service dalam seluruh operasional yang ada sesuai dengan standar operasional prosedur dengan baik dan benar. Standar operasional prosedur dirancang untuk memudahkan karyawan front office dalam proses operasional sehari-hari dan sebagai dasar dalam memberikan pelayanan.
 
This research focuses on the implementation of excellent service which is based on or guided by standard operating procedures by looking at the operational conditions that take place within the specified period. The purpose of this study was to determine the implementation of excellent service by the front office to increase satisfaction and to determine the level of guest satisfaction with service by implementing excellent service to find out how effectively excellent service was applied in standard operating procedures. This study uses a qualitative descriptive method by comparing the percentage value to determine the difference between each indicator in the applicable standard operating procedures, so that data presentation can be carried out to draw conclusions. Data collection methods in this study were observation, interviews, documentation, and data reduction using a questionnaire. The results of this study indicate that all front office employees at The Wakanda Ubud have implemented excellent service in all existing operations in accordance with standard operating procedures properly and correctly. Standard operating procedures are designed to facilitate front office employees in daily operational processes and as a basis for providing services.
Modifikasi Produk Butter Cookies Menggunakan Tepung Kacang Merah
Authors: Kangga Franky Surya , Wirawan Putu Eka
Published: October 2023

Butter cookies adalah kue kering renyah yang terbuat dari tepung kue, margarin, telur, dan gula bubuk, dimixer hingga berwarna pucat. Lalu, dibentuk dan diletakkan di atas baking tray yang telah dilapisi margarin lalu dioven hingga berwarna cokelat keemasan.Peneliti ingin membuat inovasi baru yaitu membuat butter cookies dengan campuran tepung kacang merah yang dimana kacang merah memiliki berbagai macam manfaat yaitu menyehatkan saluran pencernaan, mencegah kolesterol, menurunkan resiko diabetes, menurunkan berat badan, baik untuk kesehatan jantung, dan menurunkan resiko kanker. Tujuan penelitian ini adalah untuk mengetahui kualitas, umur simpan serta biaya yang dikeluarkan dalam pembuatan produk tersebut. Percobaan ini menggunakan formulasi yang terdiri dari 80% tepung kacang merah dan 20% tepung kue yang akan diujikan kepada 20 orang panelis untuk mengukur dari segi warna, tekstur, rasa, dan aroma. Metode pengumpulan data yang digunakan adalah data kualitatif dan data kuantitatif. Dalam 7 hari, butter cookies substitusi tepung kacang merah disimpan pada suhu ruang tidak mengalami perubahan mulai dari segi tekstur, aroma, rasa, dan warna. Biaya yang diperlukan adalah sebesar Rp 42.231,- sedangkan dengan per satu pieces dengan berat 20 gram sebesar Rp 2.000,-
 
Butter cookies are crispy pastries made from cake flour, margarine, eggs, and powdered sugar, mixed until pale in color. Then, it is shaped and placed on a cake tray covered with margarine and then baked in today's brown color. Researchers want to make a new innovation, namely making butter cakes with a mixture of red bean flour where red beans have various benefits, namely healthy digestive tract, preventing cholesterol, risk diabetes, lose weight, good for health, and reduce risk. The purpose of this study was to determine the quality, shelf life, and costs incurred in the manufacture of these products. This experiment uses a formulation consisting of 80% red bean flour and 20% cake flour which will be tested on 20 panelists to measure in terms of color, texture, taste, and aroma. Data collection methods used are qualitative data and quantitative data. Within 7 days, butter cookies substituted with red bean flour were stored at room temperature and did not change in terms of texture, aroma, taste, and color. The cost required is Rp. 42,231, - while one piece weighing 20 grams is Rp. 2,000.
Tinjauan Kualitas Permen Berbahan Dasar Kulit Jeruk
Authors: Olivia Ni Putu Mira , Sulasmini Ni Made Ayu
Published: October 2023

Penelitian eksperimen ini dirancang sebagai sebuah eksperimen inovasi olahan produk pilihan untuk masyarakat terutama petani jeruk yang kebingungan memanfaatkan hasil penennya saat musim panen jeruk. Penelitian ini bertujuan untuk mengetahui kualitas dari permen berbahan dasar kulit jeruk dari segi rasa, warna, tekstur, tampilan, daya tahan atau masa kadaluarsa permen berbahan dasar kulit jeruk di suhu ruang dan analisis biaya yang dikeluarkan dalam pembuatan permen berbahan dasar kulit jeruk ini. Metode yang digunakan dalam penelitian ini adalah melakukan studi pustaka dengan membaca dan mempelajari berbagai buku referensi (artikel, jurnal, dan yang lainnya), observasi mengamati berapa lama daya tahan permen berbahan dasar kulit jeruk, dan dokumentasi semua proses penelitian dari persiapan bahan, proses pembuatan permen berbahan dasar kulit jeruk dan penyebaran kuisioner uji organoleptic kepada 10 panelis terlatih yang terdiri dari sous chef pastry dan commis pastry Four Seasons Bali Jimbaran. Hasil penelitian ini menunjukkan bahwa kualitas permen berbahan dasar kulit jeruk dari segi rasa adalah sangat enak, segi warna sangat menarik, segi tekstur sangat kenyal dan segi tampilan sangat menarik. Daya tahan permen dapat bertahan selama 3 hari di suhu ruang ( 20ºC - 25ºC ), dan hasil perhitungan analisis biaya dalam pembuatan permen berbahan dasar kulit jeruk ini didapatkan hasil bahwa jika dalam satu kemasan pembeli akan mendapatkan 5pcs permen dengan berat 5gr/pcs maka permen akan dijual dengan harga Rp 10.000,-/kemasan.
 
This experimental research was designed as an experimental innovation of selected products for the community, especially citrus farmers who are confused about how to use their harvest during the citrus harvest season. This study aims to determine the quality of candy made from orange peel in terms of taste, color, texture, appearance, durability or expiration date of candy made from orange peel at room temperature and analyze the costs incurred in making this candy made from orange peel. The method used in this research is to conduct a literature study by reading and studying various reference books (articles, journals, and others), observing how long the shelf life of candies made from orange peel, and documentation of all research processes from material preparation, manufacturing process. candy made from orange peel and the distribution of organoleptic test questionnaires to 10 trained panelists consisting of sous chef pastry and commis pastry Four Seasons Bali Jimbaran. The results of this study indicate that the quality of candy made from orange peel in terms of taste is very good, the color is very attractive, the texture is very chewy and the appearance is very attractive. The durability of the candy can last for 3 days at room temperature (20ºC - 25ºC), and the results of the calculation of the cost analysis in making candy made from orange peel show that if in one package the buyer will get 5 pcs of candy weighing 5gr/pcs, the candy will sold at a price of Rp. 10,000, -/package.
Death to the Welfare State: An Exposition on Political Discourse and Artistic Collaboration
Authors: Kent G R Olofsson  , Jörgen Dahlqvist
Published: October 2023

Död åt välfärdsstaten (Death to the Welfare State) was a theatre performance for actors, dancers, and musicians that dealt with a concern that the welfare system in Sweden was about to be dismantled. To explore this worry political speeches were superimposed with a narrative inspired by George Orwell’s novel Animal Farm to examine how perceptions of welfare in Sweden have changed from the early 1900s to the present. This artistic research exposition elaborates on the process of developing the theatre piece. It unpacks how the relation between discourse and narrative informed the text and music, and how it allowed for a dramaturgical structure that included all the various performative elements and artistic expressions. Furthermore, the exposition discusses how the performance was composed through a collaboration that was characterised by an open-ended dialogue between the artists and how this enabled distributed decision making, as well as artists performing in other ways than they are used to. The exposition explores the open format of Research Catalogue. Through text and video documentation it builds on the dramaturgical structure of the performance itself: an introduction, five parts and an epilogue. The ambition of the exposition has been to make yet another iteration of the performance.
Untitled Document
Authors: Negrão-Rodrigues Vanessa
Published: October 2023

An increase in salinity is one of the environmental conditions that will
have the greatest impact on mangroves in coming decades. However, little
is known about the ability of mangrove seedlings to maintain their
growth and physiological adaptation to salinization over time. Here, we
examined the impact of salinity increase duration on the growth,
hydraulic properties, and tissue characteristics of seedlings of two
mangrove species, Avicennia germinans and Rhizophora
racemosa. We observed that the salinity increase had minimal impact on
plant’s growth, possibly due seedlings capacity for acclimation, as both
species demonstrated coordinated adjustments to salinity in traits such
as HSM, Ψ , Ψ , Ψ
e Ψ . However, the two species exhibited distinct
strategies, with R. racemosa showing a more conservative
behavior, while A. germinans adopting a riskier strategy. After
three months of exposure to the salinity gradient, osmotic adjustments
of the species did not persist. This discontinuity could represent a
risk to the maintenance of growth and survival of the species over
extended periods. Therefore, our results demonstrated the ability of
mangrove seedlings to physiologically acclimate and sustain their growth
in the presence of increasing salinity. They also raised concerns
regarding the prolonged exposure to higher salinity concentrations.
Arctic kelp forest decline -- a consequence of melting glaciers?
Authors: Düsedau Luisa , Fredriksen Stein , Brand Markus , Fischer Philipp , Karsten Ulf , Bischof Kai , Savoie Amanda , Bartsch Inka
Published: October 2023

The Arctic archipelago of Svalbard is a hotspot of global warming and
many fjords experience a continuous increase in seawater temperature and
glacial melt while sea-ice cover declines. In 1996/98 and 2012-14
macroalgal biomass and species diversity were quantified at the study
site Hansneset, Kongsfjorden (W-Spitsbergen) in order to identify
potential changes over time. In 2021, we repeated the earlier studies by
stratified random sampling (1x1 m2, n=3) along a sublittoral depth
transect (0, 2.5, 5, 10 and 15m) and investigated the lower depth limits
of dominant brown algae between 2-20m. The fresh weight maximum was 11.5
kg m-2 at 2.5m and kelp blades stored 277g carbon m-2 and 18g nitrogen
m-2 at this depth. Although biomass did not significantly change since
2012/13, the ‘Digitate Kelps’ community (Laminaria digitata/Hedophyllum
nigripes) changed to an Alaria esculenta dominated kelp forest in 2021
and a balanced age structure of kelps (juveniles plus many older kelp
individuals) was only apparent at 2.5m. In addition, the abundances and
lower depth limits of all dominant brown algae declined noticeably over
the last 25 years while the deep red algae flora remained stable. As we
revealed that biomass allocation to blades, stipes and holdfasts as well
as the ability to store blade carbon and nitrogen was kelp
species-specific, a pronounced shift in the functionality of the kelp
forest had occurred over time. We propose that the observed changes in
the macroalgal community are mainly driven by alterations in underwater
light climate as in situ data confirmed increasing turbidity and
decreasing irradiance since 2012 and 2017, respectively. As a
consequence, the overall retreat of the kelp forest to lower depth
levels seems to be a result of strong glacial melt and will possibly
continue in future with unforeseen consequences for Arctic coasts and
their socio-ecological fjord systems.
An improved maximum tangential stress criterion for one oblique crack under uniaxial compression considering T -stress and crack parameter
Authors: Liu Hongyan , Zhu Fengjin , ZHOU Yuezhi , LIU Kangqi
Published: October 2023

The engineering rockmass is often prone to compression, therefore how to
establish a fracture criterion to reflect the rockmass compression
failure is vital. Take the rockmass with one oblique crack for instance,
the mechanical behavior of the oblique crack face closure and friction
sliding under uniaxial compression is firstly analyzed, and then the
Kolossoff-Muskhelishvilli stress function of the rockmass under uniaxial
compression is established based on the complex stress functions. Next,
the calculation methods of the stress intensity factor (SIF) K
and three T-stress components at or near the crack tip
considering three kinds of crack parameters (e.g. geometry parameter,
friction strength parameter and deformation parameter) are obtained.
Thirdly, the improved maximum tangential stress (MTS) criterion is
obtained considering T-stress and three kinds of crack
parameters. Finally, the relevant experiments done by other researchers
are adopted to verify the improved MTS criterion. Meanwhile, the effect
of γ, the crack normal stiffness k and
shear stiffness k, and the crack friction
coefficient f on the wing-crack initiation angle are discussed
with the parametric sensitivity analysis.
Hypericum alpestre extract exhibits in vitro and in vivo anticancer properties by regulating the cellular antioxidant system and metabolic pathway of L-arginine
Authors: Avtandilyan Nikolay , Ginovyan Mikayel , Javrushyan Hayarpi , Karapetyan Hasmik , Koss-Mikołajczyk Izabela , Kusznierewicz Barbara , Grigoryan Anna , Maloyan Alina , Bartoszek Agnieszka
Published: October 2023

Conventional treatment methods are not effective enough to fight the
rapid increase in cancer cases. The interest is increasing in the
investigation of herbal sources for the development of new anticancer
therapeutics. Particularly, much attention is given to finding combined
phytochemical/chemotherapeutic treatment models to overcome drug
resistance and decrease side effects. The aim was to investigate the
antitumor capacity of Hypericum alpestre herb extract in
vitro and in vivo, either alone or combined with the inhibitors
of the L-arginine/polyamine/nitric oxide pathway and characterize its
active phytochemicals using advanced chromatographic techniques. The
antioxidant capacity of H. alpestre extract was assessed through
chemical spectrophotometric tests (DPPH and ABTS) and in biological
systems using Cellular Antioxidant Activity assay. The inhibitory effect
of H. alpestre extract on the growth of human colorectal (HT29)
and breast cancer (MCF-7) cell cultures was explored by the MTT test.
The genotoxicity of the tested extract was studied using a comet assay.
In vivo, the antitumor properties of H. alpestre and its
combinations were explored in a rat mammary gland carcinogenesis model
induced by subcutaneous injection of 7,12-dimethylbenz[a]anthracene.
The polyphenolic substances present in H. alpestre extract have
been characterized using the LC-Q-Orbitrap HRMS system. The H.
alpestre extract expressed promising antiproliferative effects on MCF-7
and HT29 cells. The extract did not exhibit genotoxic activity nor
possessed antigenotoxic properties. The in vivo rat mammary
carcinogenesis model data showed that the H. alpestre extract
stimulated the activity of antioxidant enzymes in the liver, brain, and
tumors of rats in the experimental groups, demonstrating its antioxidant
protective effects. The herb alone and in combination with N
-OH-nor-L-arginine and N
-nitro-L-arginine methyl ester exhibited
pro-/antioxidant, antiproliferative, anti-angiogenic, and cytotoxic
effects.
A Large Fronto-nasal-maxillary Bone Flap Technique for the Removal of an Invasive Ethmoid Hematoma in a Horse
Authors: Amitrano Fernando , Brabon Ashley , Quiroz Lorenzo
Published: October 2023

An 8-year-old Thoroughbred gelding presented for evaluation and
investigation for recurrent unilateral epistaxis. Computer tomography
(CT) confirmed the presence of an invasive and expansive progressive
ethmoid hematoma (PEH) located in the right paranasal sinuses. The mass
invaded the right paranasal sinuses compartments causing moderate
leftward displacement of the nasal septum with subsequent collapse of
the left nasal passages, complete obliteration of the right ethmoid
turbinate, right infraorbital canal, and nasolacrimal duct. Also,
impingement of the axial margin of the right orbit. A large frontonasal
maxillary bone flap was performed standing under sedation and local
anesthesia and the PEH was removed successfully with minimal surgical
complications. The gelding made an unremarkable recovery from surgery
and progressed well after recovering from post operative
pleuropneumonia. Follow-up (25 months post operative) confirmed the
reoccurrence of the PEH, but the horse remained healthy in pasture turn
out.
Combined therapy with pirfenidone and nintedanib counteracts fibrotic silicosis in mice
Authors: Bai Lu , Wang Jiaxin , Wang Xue , Wang Jixin , Zeng Wei , Pang Junling , Zhang Tiantian , Li Shengxi , Song Meiyue , Wang Jing , Wang Chen
Published: October 2023

Abstract Background and Purpose Pneumoconiosis, especially silicosis has
emerged as a prominent occupational disease with remarkable global
implications with no definitive cure available. While pirfenidone and
nintedanib have been approved in treating idiopathic pulmonary fibrosis,
their potential efficacy as anti-fibrotic agents in advanced silicosis
warrants further investigation. Thus, we aimed to assess the individual
and combined effects of pirfenidone and nintedanib in treating advanced
silicosis mice and further elucidate the underlying mechanisms involved
in their therapeutic actions. Experimental Approach We administrated
monotherapy or combination therapy of pirfenidone and nintedanib with
low and high doses in silicosis mouse models established after 6 weeks
and then evaluated lung function, inflammatory responses, and fibrotic
status. Moreover, we employed transcriptomic and metabolomic analyses to
unravel the mechanisms underlying different therapeutic strategies. Key
Results Both pirfenidone and nintedanib were demonstrated to be
effective for advanced silicosis, with superior outcomes when used in
combination. Transcriptomic and metabolomic analyses revealed that
pirfenidone and nintedanib primarily exerted their therapeutic effects
through modulation of immune responses, signaling cascades, circadian
rhythm, and metabolic processes of substances including lipid, amino
acids, nucleotides, and carbohydrates. Conclusion and Implications In
conclusion, pirfenidone and nintedanib, either administered individually
or in combination, exhibit remarkable potential in advanced silicosis
mouse models. Further, combined therapy outperformed monotherapy even at
a half dose. These therapeutic benefits are attributed to their
influence on diverse signaling pathways and metabolic processes.
Keywords: silicosis, pulmonary fibrosis, pirfenidone, nintedanib,
multi-omics.
Enhancement of Nitrogen Reduction Reaction Activity of sp-B-doped γ-Graphyne Nanotubes through Curvature Effect
Authors: Ma Rongwei , Lv Yipin , Yang Yuejiao , Wei Xinru , Lee Jin Yong , Mukamel Shaul , Kang Baotao
Published: October 2023

Developing novel, metal-free materials as efficient catalysts for the
electrochemical nitrogen fixation reaction (NRR) to replace the
Haber-Bosch process remains a significant challenge. Herein, γ-graphyne
nanotubes (γGyNTs) doped with single sp2-B or sp-B were developed as
electrocatalysts. The NRR activity of the doped γGyNTs was studied by
intensive density functional theory (DFT) calculations. The results
reveal that the curvature effect significantly enhances the catalytic
activity of sp-B-doped γGyNTs, in contrast with that achieved via sp2-B
doping. The limiting potential of sp-B-doped (2, 0)-γGyNT is predicted
to be −0.071 V, which is significantly superior to that of previously
reported metal-free catalysts (MFCs). Moreover, the competing hydrogen
evolution reaction (HER) is suppressed by sp-B-doped (2, 0)-γGyNT.
Analysis of the catalytic mechanism revealed that the enhanced NRR
activity of the sp-B doped γGyNTs mainly originates from the synergistic
effects of the enhanced exposure of the p-orbital and positive charge on
the sp-B dopants induced by the curvature effect, which can alter the
interactions with intermediates. The present findings are insightful and
suggest a new strategy for designing graphyne-related materials as
high-performance non-metallic NRR catalysts.
Accidental Allergic Reactions to Immediate-Type Food Allergens in Japanese Children: A Single-Center Study
Authors: Yanagida Noriyuki , Miura Yoko , Nagakura Ken-ichi , Takahashi Kyohei , Sato Sakura , Ebisawa Motohiro
Published: October 2023

Background: Accidental allergic reactions (AAR) in children are
under-studied, especially with precise pediatrician-based exact
diagnoses and follow-ups. This study aimed to assess the prevalence and
risk factors for AAR in Japanese children with immediate-type food
allergies. Methods: This single-center study included children
with immediate-type hen’s egg (HE), cow’s milk (CM), wheat, or peanut
allergy who had been followed-up regularly at a national center
specialized for allergy in Japan. Low-dose reactivity was defined as
allergic reactions to a low dose of ≤250, ≤102, ≤53, or ≤133 mg HE, CM,
wheat, or peanut protein, respectively. From January to December 2020,
pediatricians followed the AAR experience every 2–4 months. Risk
factors for AAR were analyzed using multiple logistic regression.
Results: Of the 1096 participants, 609, 457, 138, and 90 had
HE, CM, wheat, and peanut allergies, respectively. In this cohort, the
median age was 5.0 years, 39% had completely eliminated allergenic
food, and 24% had low-dose reactivity. The annual AAR rate was 0.130 in
all sub-cohorts. Moderate and severe symptoms occurred in 50% and
0.7%, respectively, of children who experienced AAR. Multiple logistic
regression revealed that low-dose reactivity was a significant risk
factor for AAR in the overall, HE, and CM cohorts, respectively (
p <0.001, p = 0.029 and 0.036).
Conclusion: In Japanese children with immediate-type food
allergies, the annualized rate of AAR was relatively low; however, half
of the participants with AAR had moderate to severe symptoms. Children,
especially those with low-dose reactivity, would require careful risk
management of AAR.
Mucosal antibody response and SARS-CoV-2 shedding in patients with COVID-19 related olfactory dysfunction
Authors: Sharma Shilpee , Thiriard Anaïs , Olislagers Véronique , Lechien Jerome R. , Jurion Marie-Hélène , Delforge Marie-Luce , Marchant Arnaud , Saussez Sven
Published: October 2023

Olfactory dysfunction was one of the most common symptom of infection
with the Wuhan strain of SARS-CoV-2 and could persist for several months
after symptom onset. The pathogenesis of prolonged olfactory dysfunction
(OD) remains poorly understood but probably involves sustained viral
replication associated with limited mucosal immune response to the
virus. This prospective study was conducted to investigate the potential
relationship between nasal SARS-CoV-2 viral load and antibody levels in
patients with loss of smell. One hundred and five patients were
recruited 2 weeks after presenting with confirmed COVID-19 associated
OD. Based on the identification sniffing test performed at enrollment,
52 patients were still anosmic or hyposmic and 53 were normosmic.
SARS-CoV-2 was detectable in nasal wash of about 50% of anosmic and
normosmic patients. Higher viral load was detected in anosmic patients
with lower levels of SARS-CoV-2 specific nasal IgG and IgA. This
association was not observed in normosmic patients. No relationship
between nasal viral load and antibodies to endemic coronaviruses was
observed. SARS-CoV-2 replication in the nasal cavity may be promoted by
defective mucosal antibody responses in patients with OD. Boosting
mucosal immunity may limit nasal SARS-CoV-2 replication and thereby help
in the control of persistent OD.
Voxel Volumes and Biomass: estimating vegetation volume and litter accumulation of exotic annual grasses using automated ultra-high resolution SfM and advanced classification techniques
Authors: Enterkine Josh , Hojatimalekshah Ahmad , Vermillion Monica , Weide Thomas Van Der , Arispe Sergio , Price William , Hulet April , Glenn Nancy
Published: October 2023

Rangelands and semi-arid ecosystems are subject to increasing changes in
ecologic makeup from a collection of factors. In much of the northern
Great Basin, rangelands invaded by exotic annual grasses such as
cheatgrass (Broumus tectorum) and medusahead (Taeniatherum
caput-medusae) are experiencing an increasingly short fire cycle which
is compounding and persistent. Improving and expanding ground-based
field methods for measuring above-ground biomass (AGB) may enable more
sample collections across a landscape and over succession regimes, and
better harmonize with other remote sensing techniques. Developments and
increased adoption of uncrewed aerial vehicles and instrumentation for
vegetation monitoring are enabling greater understanding of vegetation
in many ecosystems. Research towards understanding the relationship of
traditional field measurements with newer aerial platforms in rangeland
environments is growing rapidly, and there is increasing interest in
exploring the potential use both to quantify AGB and fine fuel load at
pasture scales. Our study here uses relatively inexpensive handheld
photography with custom sampling frames to collect and automatically
reconstruct 3D-models of the vegetation within 0.2 m2 quatrats (n =
288). Next, we examine the relationship between volumetric estimates of
vegetation to compare with biomass. We found that volumes calculated
with 0.5 cm voxel sizes (0.125 cm3) most closely represented the range
of biomass weights. We further develop methods to classify ground
points, finding a 2% reduction in predictive ability compared to using
the true ground surface. Overall, our reconstruction workflow had an R2
of 0.42, further emphasizing the importance of high-resolution imagery
and reconstruction techniques. Ultimately, we conclude that more work is
needed of increasing extents (such as from UAS) to better understand and
constrain uncertainties in volumetric estimations of biomass in
ecosystems with high amounts of invasive annual grasses and fine fuel
litter.
Effect of loading rate and coating thickness on wear and adhesion during sliding indents of Si-C-N hard coatings deposited on glass substrates
Authors: Bhattacharyya A S
Published: October 2023

Scratch tests were done on thermally resistant hard Si-C-N coatings developed on glass substrates using magnetron sputtering. The change in loading rate and coating thickness showed variation in adhesion strength and wear, The Boussinesq, Hans and Blister stress distribution beneath the indenter had on effect of the failure processes. Elastic recovery was prevalent in coatings of higher thickness and higher rate of loading. The increased loading rate although caused early failure but resulted in less wear.
A nomogram to predict survival in patients older than 65 years with rectal cancer: A SEER-based population study
Authors: nong sikai , huang huan , Mo qiyan , Zhang Weiming
Published: October 2023

Background: There has been no construction of nomograms specifically
geared towards pblueicting the prognosis of older patients with rectal
cancer. Our objective was to create a nomogram that can accurately
pblueict the chances of cancer-specific survival (CSS) and overall
survival (OS) for older patients with rectal cancer,stratifying them
into distinct risk groups. Methods: Data of older than 65 years with
rectal cancer from the Surveillance, Epidemiology, and End Results
(SEER) database between 2000 and 2020 were extracted. Results: A total
of 12,780 patients were collected in order to identify the independent
prognostic factors for cancer-specific survival (CSS) and overall
survival (OS) and construct nomograms. The factors included age, sex,
race,year of diagnos, marital status, grade, tumor size, CEA, T
classification, N classification, Months from diagnosis to treatment,
surgery, chemotherapy, and radiation. LASSO regression was used for this
purpose. The results showed that grade, chemotherapy, and months from
diagnosis to treatment were identified as independent prognostic factors
for OS, while grade, chemotherapy, and tumor size were identified as
independent prognostic factors for CSS. The concordance index of the CSS
nomogram was 0.609 (95% confidence interval [CI], 0.598-0.619) in
the training cohort and 0.682 (95%CI, 0.665-0.698) in the validation
cohort. The concordance index of the OS nomogram was 0.697 (95%CI,
0.686-0.708) in the training cohort and 0.605 (95%CI, 0.589-0.621) in
the validation cohort. Conclusion: Caution should be taken when
administering adjuvant therapy after surgery in older patients with
rectal cancer,as we have developed and validated a new pblueictive
nomogram for CSS and OS.
Electroacupuncture alleviates MIRI by regulating hypothalamic paraventricular nucleus neurons projecting to the rostral ventrolateral medulla
Authors: Shu Qi , Zhou Jie , Zhang Bin , Zhang Fan , Zhou Xiang , Wu Yan , Chang Huiming , Hu Ling , Cai Ronglin , Yu Qing
Published: October 2023

Accumulating evidence suggests that electroacupuncture (EA) has obevious
therapeutic effects and unique advantages in alleviating myocardial
ischemia-reperfusion injury (MIRI), while the underlying neuromolecular
mechanisms of EA intervention for MIRI have not been fully elucidated.
The aim of the study is to investigate the role of the neural pathway of
hypothalamic paraventricular nucleus (PVN) neurons projecting to the
rostral ventrolateral medulla (RVLM) in the alleviation of MIRI rats by
EA preconditioning. MIRI models were established by ligating the left
anterior descending coronary artery for 30 min followed by reperfusion
for 2 h. Electrocardiogram recording, chemogenetics, enzyne-linked
immunosorbent assay, multichannel physiology recording,
hematoxylin-eosin and immunofluorescence staining methods were conducted
to demonstrate that firing frequencies of neurons in the PVN and
expression of c-Fos decreased by EA pretreatment. Meanwhile, EA
preconditioning significantly reduced the levels of creatine kinase
isoenzymes (CK-MB), cardiac troponin I (cTnI) and lactic dehydrogenase
(LDH). Virus tracing showed a projection connection between PVN and
RVLM. Inhibition of the PVN-RVLM neural pathway could replicate the
protective effect of EA pretreatment on MIRI rats. However, activation
of the pathway weakened the effect of EA preconditioning. EA
pretreatment alleviated MIRI by regulating PVN neurons projecting to
RVLM. This work provides novel evidence of EA pretreatment for improving
MIRI.
Long-time dynamics for a piezoelectric system with time-varying delay and memory
Authors: Liu Gongwei , Wang Mengru , Wang Xiaoli
Published: October 2023

In this paper, we study the long time dynamics of piezoelectric system
with damping term, past history and time-varying delay effects. We prove
the well-posedness of the solution by the semigroup theory. Then the
existence of global attractors with finite fractal dimension and the
existence of exponential attractors are proved. Moreover, the upper
semicontinuity of the global attractor is shown. Finally, the fact that
the total energy of the system decays exponentially under suitable
conditions is also derived.
Understanding the Role of External Events in Major Policy Change: The Case of Abolition of China’s Labor Reeducation System
Authors: Shang Huping , Li Yan , Liu Hongmei
Published: October 2023

External events impact significant policy changes. This study integrates
the Advocacy Coalition Framework, Multiple Streams model, and Punctuated
Equilibrium Theory to analyze how external events influenced China’s
abolition of the Labor Reeducation System (LRS). Findings show that
external events broke through decision makers’ attention constraints,
shifted power dynamics, and created an opportunity for change. Limited
learning occurred within coalitions as a tactical response to shocks,
while intercoalition learning resulted from higher authorities’
interference. Destabilizing events reduce consensus requirements and
reinforce China’s authoritarian decision-making style. The role of
external events depends on their alignment with the Communist Party of
China’s (CPC) ideology and political interests.
Incidence of Type 1 Diabetes in Relation to Exposure to Rotavirus Infections in Pre- and Post-Vaccine Birth Cohorts in Finland
Authors: Parviainen Anna , But Anna , Sund Reijo , Arffman Martti , Siljander Heli , Knip Mikael
Published: October 2023

Objective To explore the incidence of type 1 diabetes in children in relation to exposure to rotavirus infections.

Research Design and Methods A nationwide register-based ecological study on the 1995–2015 birth cohorts in Finland, comparing those born before and after the national implementation of the rotavirus vaccine in 2009.

Results When comparing the pre-vaccine 2001–2005 birth cohorts to the post-vaccine birth cohorts, the number of children exposed to rotavirus infection by the age of 5 years decreased from 2522 per 100 000 children (2.5%) to 171 per 100 000 children (0.2%), whilst the incidence of type 1 diabetes in those aged below 5 years decreased from 71.5 to 54.4 per 100 000 person-years (incidence rate ratio 0.79, 95% CI 0.71 to 0.86).

Conclusions At the population level, a decrease in exposure to rotavirus infections was associated with a decrease in the incidence of type 1 diabetes in young child.
Divergent Skeletal Muscle Metabolomic Signatures of Different Exercise Training Modes Independently Predict Cardiometabolic Risk Factors
Authors: W. Pataky Mark , Prabha Kumar Arathi , A. Gaul David , G. Moore Samuel , Dasari Surendra , M. Robinson Matthew , A. Klaus Katherine , Aneesh Kumar A. , M. Fernandez Facundo , Sreekumaran Nair K.
Published: October 2023

We investigated the link between enhancement of insulin sensitivity (SI) (by hyperinsulinemic-euglycemic clamp) and muscle metabolites following 12-weeks of aerobic (high-intensity interval training, HIIT), resistance (RT), or combined (CT) exercise training in 52 lean healthy people. Muscle RNA-sequencing revealed a significant association between SI following both HIIT and RT and the branched chain amino acid (BCAA) metabolic pathway. Concurrent to increased expression and activity of branched chain ketoacid dehydrogenase enzyme, many muscle amino metabolites including BCAAs, glutamate, phenylalanine, aspartate, asparagine, methionine, and GABA increased by HIIT, supporting substantial impact of HIIT on amino acid metabolism. Short-chain C3 and C5 acylcarnitines were reduced in muscle by all three training modes, but unlike RT, both HIIT and CT increased TCA metabolites and cardiolipins, supporting greater mitochondrial activity by aerobic training. Conversely, RT and CT increased more plasma membrane phospholipids than HIIT, suggesting a resistance exercise effect on cellular membrane protection against environmental damage. Sex and age contributed modestly to the exercise-induced changes in metabolites and their association to cardiometabolic parameters. Integrated transcriptomic and metabolomic analyses suggest various clusters of genes and metabolites are involved in distinct effects of HIIT, RT, and CT. These distinct metabolic signatures of different exercise modes independently link each type of exercise training to improved SI and cardiometabolic risk.

ARTICLE HIGHLIGHTS:

· We aimed to understand the link between skeletal muscle metabolites and cardiometabolic health after exercise training.

· Although aerobic, resistance, and combined exercise training each enhance muscle insulin sensitivity as well as other cardiometabolic parameters, they disparately alter amino and citric acid metabolites as well as lipidome, linking these metabolomic changes independently to improvement of cardiometabolic risks by each exercise training mode.

· These findings reveal an important layer of the unique exercise mode-dependent changes in muscle metabolism which may eventually lead to more informed exercise prescription for improving SI.
Strategi Mobilisasi Orkestrasi Pada Bisnis "Omo Korean Street Food"
Authors: Asri Anak Agung Sagung Mas Anastassia Nawang
Published: October 2023

The boom of K-Pop, especially among teenagers, has its own value for businesses that "smell" Korea. What is needed is mobilization and orchestration strategy. The mindset now is no longer conquering but creating collaboration. This study discusses strategies used by Korean culinary hawker business owners. The research method used is qualitative with a phenomenological approach. Data collection techniques using in-depth interviews and documentation. Business can be started from what we really like or are currently liking, especially when it comes to a phenomenon. Today's business can take advantage of the orchestration mobilization strategy that results in a collaboration in creating harmonization
Pengaruh Motivasi Kerja Terhadap Kinerja Karyawan Dengan Kompensasi Sebagai Variabel Moderasi (Studi Pada PT. Japfa Comfeed Indonesia Tbk Unit Pupuan)
Authors: Kurniati Kadek Juli , Heryanda Komang Krisna
Published: October 2023

The purpose of this research is to investigate how work motivation influences employee performance, by considering compensation as a moderating factor. A qualitative approach with a causal design is defined in this study and implemented at PT. Japfa Comfeed Indonesia Tbk Pupuan Unit. As this study aimed to cover the entire population, the sample size consisted of 40 individuals. The questionnaire was used as an instrument in data collection with the data analysis technique in the form of moderated regression analysis (MRA). The results obtained show that: (1) work motivation influences employee performance positively and substantially, and (2) compensation plays a positive and substantial role in moderating the relationship between work motivation and employee performance.