bluuebunny/crossref_metadata_2025 huggingface dataset:
A study on Regional Comparison for the Health Level using GLMM
Authors:   The Korean Data Analysis Society, Lee Jinwoo , Kim Youngsoon , Lee Gyemin , Seol Hyunuk
Published: December 2022

In this paper, we first examined the problem of the direct standardization method, which is mainly used to measure the regional health level by analyzing the data obtained from the Korea Community Health Survey, and proposed a new standardization method based on the Generalized Linear Mixed Model (GLMM). In order to evaluate the performance of the proposed standardization as an alternative to the existing direct standardization method, we used the data which obtained from the Korea Community Health Survey conducted in 2019. Using this data, we compared and analyzed three regional health level standard values through the new standardization method, GLMM, the direct standardization method based on the national population in 2005, and the direct standardization method based on the national population in 2019. The results of this study can be summarized as follows. First, the direct standardization method currently used is based on the national population estimated in 2005, but it does not reflect the current demographic structure that is aging much. Second, the GLMM-based standard value correlated higher with 2019 standardization rate than with 2005 standardization rate, which implies that the proposed standardization method sufficiently reflects demographic changes.
Finally, GLMM-based standard value was related to the disease variables and health-related variables, which were mostly similar to those shown in the direct standardization rates.
Widening Price Limit Effects on Volatility : Using Portfolio Return and EGARCH Model
Authors:   The Korean Data Analysis Society, Lee Eunkwang , Hyung Namwon
Published: December 2022

This study examines how the relaxation of daily price limits affected volatility in the Korean stock market. Previous studies failed to conclusively determine the effect of relaxed price limits on volatility, with some concluding that volatility actually increased, while others empirically demonstrated the opposite. Such inconsistent results were due to the lack of a control group in those studies. In order to avoid the same pitfalls, we compared two markets: the KOSPI and KOSDAQ indices. Over the years, both markets experienced gradual relaxation of their respective daily price limits. This study focuses on four separate events where the price limit of one market was relaxed compared to before, while its counterpart maintained the status quo. Moreover, we employed a single criteria when selecting stocks for portfolios in each market, with regards to company size and book-to-market ratio. It is expected that such precautions will improve homogeneity between the portfolios compared, thus excluding factors other than the relaxation policy that might affect stock price volatility. Through such efforts, we reached the conclusion that the net effect of recent relaxations in price limits was to decrease the volatility of stock prices.
Characteristics of adolescents who smoke daily
Authors:   The Korean Data Analysis Society, Park Min-Hee
Published: December 2022

The purpose of this study was to examine the general, smoking-related, and mental health characteristics of adolescents who smoke every day. The subjects of the study were 1,186 people who had smoked in the raw data of the smoking and drinking situation of students in 2021 surveyed by the Office of Education in B city. The collected data were statistically processed using the SPSS 27.0 program. The subjects' general, smoking-related, and mental health characteristics were analyzed by frequency and percentage, mean and standard deviation, and ANOVA. As a result of the study, high school students had a higher rate of daily smoking, and daily smokers had lower scores on subjective academic achievement and subjective health cognition, and the current use of heated e-cigarettes was high. Also, the ratio of the preparation phase was low in the smoking cessation change phase, and the ratio of quitting attempts and quitting success was also low. Regarding secondhand smoke, the ratio of daily smoking among students exposed to secondhand smoke at home, school, and public places was higher, and the stress perception and depression and impulsiveness scores of adolescents who smoked every day were higher. It is necessary to develop an educational program for smoking prevention and cessation by including daily smoking-related characteristics as intervention factors.
Investigation on the application of artificial intelligence in prosthodontics
Authors:   King Khalid University, SAINI RAVINDER , Alshadid AbdulKhaliq , Aldosari Lujain
Published: December 2022

Review question / Objective: 1. Which artificial intelligence techniques are practiced in dentistry? 2. How AI is improving the diagnosis, clinical decision making, and outcome of dental treatment? 3. What are the current clinical applications and diagnostic performance of AI in the field of prosthodontics? Condition being studied: Procedures for desktop designing and fabrication Computer-aided design (CAD/CAM) in particular have made their way into routine healthcare and laboratory practice.Based on flat imagery, artificial intelligence may also be utilized to forecast the debonding of dental repairs. Dental arches in detachable prosthodontics may be categorized using Convolutional neural networks (CNN). By properly positioning the teeth, machine learning in CAD/CAM software can reestablish healthy inter-maxillary connections. AI may assist with accurate color matching in challenging cosmetic scenarios that include a single central incisor or many front teeth. Intraoral detectors can identify implant placements in implant prosthodontics and instantly input them into CAD software. The design and execution of dental implants could potentially be improved by utilizing AI.
Agricultural Transformation in Asia: Experiences and Emerging Challenges
Authors:   Food and Agriculture Organization of the United Nations (FAO/UN) Bangkok, Thailand, Arya Aziz R.
Published: December 2022

Agriculture plays a key role in economic development, alleviating poverty and malnutrition, especially in the early stages of agricultural development. Several studies have demonstrated that neglecting agriculture, especially at the early stages of industrialization, can disrupt the process of economic transformation. This paper reviews the process of agricultural transformation in Asia through the framework proposed by Timmer (1988). It finds that agricultural transformation in Asia has followed a uniform pattern with unique characteristics in each stage. Moreover, the public sector has been instrumental in facilitating and guiding agricultural transformation. Emerging challenges in the agri-food sector in Asia have prompted some countries to promote a more inclusive and integrated approach to rural and agri-food system development. The next phase of agricultural transformation—pioneered in Japan, Republic of Korea (South Korea), and China—seems relevant to most countries in Asia and elsewhere. In all three countries, the role of the state in facilitating the next phase of agricultural transformation is highly instrumental in terms of policy, strategy, incentives, and resources. However, there is insufficient evidence to assess the efficacy of the transformative initiatives dubbed as the “6th industrialization in agriculture.”
Perceptions on the Challenges of Banana Cultivation and Bio-based Technology Use Among Malaysian Smallholder Farmers
Authors:   Centre for Research in Biotechnology for Agriculture (CEBAR), Universiti Malaya, Kuala Lumpur, Malaysia, Jalaluddin Nurzatil Sharleeza Mat , Othman Rofina Yasmin ,   Centre for Research in Biotechnology for Agriculture (CEBAR), Universiti Malaya, Kuala Lumpur, Malaysia
Published: December 2022

Bananas are one of the most commonly grown fruit crops in Malaysia, but local production has declined in recent years. Through site visits and interviews with 74 smallholder banana farmers, this study sought to know the current situation of the local smallholder banana industry, the challenges faced in commercial banana cultivation, and the use of bio-based technologies to address the challenges. The farmers cited increasing production costs, pests and diseases, and yield uncertainties as major challenges to their plantations’ survival. While they have been using farming techniques, including bio-based technologies, to improve fruit yield, the farmers perceived the current technologies as inadequate in mitigating the impacts of frequent disease outbreaks. The interviews also reveal farmers’ misconceptions on the nature of tissue culture technology, reflecting their poor understanding of how tissue culture works, thus, putting banana farms at risk. Overall, this study’s direct engagements with banana farmers show that correct information and access to technology are a rare privilege for smallholders. Therefore, coordinated efforts to substantially increase support for smallholder farmers is paramount.
Waiting for the 7th wave of the pandemic: analysis of the COVID-19 cases from the ”Victor Babes” Hospital, Craiova
Authors:   Infectious Diseases Department, University of Medicine and Pharmacy of Craiova, Romania, Giubelan Lucian-Ion ,   ”Victor Babes” Hospital of Infectious Diseases and Pulmonology, Craiova, Romania, Dumitrescu Florentina ,   Infectious Diseases Department, University of Medicine and Pharmacy of Craiova, Romania,   ”Victor Babes” Hospital of Infectious Diseases and Pulmonology, Craiova, Romania, Diaconescu Iulian ,   ”Victor Babes” Hospital of Infectious Diseases and Pulmonology, Craiova, Romania, Fortofoiu Mircea-Catalin ,   Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, Romania, Ilie Cristina ,   ”Victor Babes” Hospital of Infectious Diseases and Pulmonology, Craiova, Romania, Georgescu Ilona ,   ”Victor Babes” Hospital of Infectious Diseases and Pulmonology, Craiova, Romania
Published: December 2022

COVID-19 is an ongoing pandemic and an analysis of the cases treated in ”Victor Babes” Hospital of Infectious Diseases and Pulmonology from Craiova. It has been performed between March 2020 and October 2022.
Demand in the Housing Market and the Needs of Russian People: an Econometric Approach
Authors:   St. Petersburg State University of Economics, Eliseeva I.I. , Bochenina M.V. ,   St. Petersburg State University of Economics
Published: December 2022

The article emphasizes the peculiarities of such goods as housing and the situation with the affordability of housing, which has developed in the modern Russian market, due to the outstripping growth rates of housing prices. The article considers regional peculiarities of emerging trends in federal districts in conditions of relatively low mortgage rates. Particular attention is paid to the scale and structure of mortgage lending in CFD, attention is paid to the increased role of investment decisions when purchasing housing in CFD by borrowers from other regions. Assessing the prospects of housing market development in the light of the demographic policy, emphasis is made on the growing discrepancy between the needs of the population for housing and the emerging demand, shifted to the purchase of more affordable small-size housing. This causes structural shifts in the supply of housing. The authors consider it possible to define this situation as “quasi-demand”, which does not solve the problem of improving housing conditions and, in fact, creates a pent-up demand, the aggravation of which is likely in the medium-term period of 7-8 years. The article is written based on official statistics with the use of econometric modeling and graphs.
How to measure creative activity?
Authors:   Lomonosov Moscow State University, Pavlov M.Yu.
Published: December 2022

The article demonstrates that unlike reproductive productivity, creative labor possesses the character of repeatedly increasing production (and/or consumption) efficiency due to positive external effects from creative activity, making “creative multiplier.” It follows from this that the key element determining economy efficiency at the both - micro and macro levels is creative human potential reproduction – worker’s ability to perform creative activity. The human role and place in reproduction scheme in the creative economy has been clarified: in addition to labor (substitutable labor in A. Freeman’s terminology), which forms variable capital v, human can also make a creative multiplier representing new social productive force. The use of creative multiplier allows to increase productivity - at the same (or lower) capital and labor costs.
Orta Mesafe Koşucularında Maksimal Egzersizin Kan Biyokimyasina Etkisi
Authors: GÜREŞ Ali
Published: December 2022

Bu çalışmanın amacı, orta mesafe koşularında maksimal egzersizin kan biyokimyasına yansıma düzeyini ve etkisini incelemektir. Yöntem olarak, milli takım düzeyinde yer alan ve ulusal müsabakalarda üst sıralarda yer almış ve en üst düzeyde antrenman yapmış, yaş ortalaması ve performans yaşı ortalaması olan 18 erkek sporcu çalışmaya dahil edilmiştir. Çalışmaya dahil edilen denekler çalışmaya başlamadan hemen önce venöz kan vakumlu düz tüplere alındı. Sporcular 2000 metre mesafeyi ortalama 5,45-1,02 dakikada koşmuştur. Aynı yöntemle koşudan hemen önce ve 1, 6 ve 24 saat sonra kan örnekleri alındı. Bulgular şöyleydi: Sporcuların kan şekeri, üre, ürik asit, kolesterol trigliserit, HDL, LDL, Fe, TDBK, Demir doygunluğu (Fe Sat), toplam protein, albümin, AST, ALT, LDH, CPK, GGT, ALP, Ca ve P değerleri ILL AB test kitleri ile çalışıldı. VLDL Frieldwald formülüne göre transferrin (TDBK/1.25) ve Fe Sat [(TDBK/Fe) x 100] olarak hesaplandı, istatistiksel analiz SPSS programında (Sürüm 8.0) Friedman testi kullanılarak yapıldı. P<0.05 değeri anlamlı kabul edildi. Belirlendi; 1 saatte kan şekeri, kreatinin, kolesterol, HDL, LDL, TDBK, transferrin, total protein, albümin, LDH, GGT, ALP, Ca ve P değerleri, üre, ürik asit, trigliserit, VLDL, AST, ALT, CPK değerleri arttı 6. saatte konsantrasyona bağlı olarak, 24 saat sonra ise egzersiz öncesi düzeyine geriledi ve bu değişim TG, VLDL ve Fe Sat değerleri dışında istatistiksel olarak anlamlıydı. Fe ve Fe Sat 24 saat sonunda en yüksek değerlerine ulaştı. Sonuç olarak antrenmana yönelik etkinliklerin gerçekleşebilmesi için özellikle dokuların oksijen ve enerji gereksinimlerinin karşılanması gerekir. Bu gereksinimler kan yoluyla solunum-dolaşım sistemleri tarafından karşılanır. Uygulanan egzersizin türü de egzersiz sonrası kan değerlerindeki değişikliklerde etkilidir. Orta mesafe koşucularının hemen hemen tüm parametrelerinin maksimal egzersiz uygulamasından 24 saat sonra egzersiz öncesi seviyeye yaklaştığı belirlendi. Kandaki demir konsantrasyonunun artması performanslarını artıracak bir bulgudur. Sporcuların 24 saat sonra tekrar antrenman yapabilecek kan biyokimyasına ulaştığını söyleyebiliriz.
Lise Öğrencilerinin Rekreatif Faaliyetlere Katılım Motivasyonları ve Engelleri ile Mental İyi Oluşları Arasındaki İlişkinin İncelenmesi
Authors: KUYULU İhsan
Published: December 2022

Bu araştırma lise öğrencilerinin rekreatif faaliyetlere katılım motivasyonları ve engelleri ile mental iyi oluşları düzeyleri arasındaki ilişkiyi incelemek amacı ile yapılmıştır. Araştırmanın örneklem grubunu, 2022-2023 eğitim öğretim döneminde Bingöl ilinde, Milli Eğitim Bakanlığına bağlı liselerde öğrenim gören gönüllü 572 öğrenci oluşturmuştur. Veri toplama aracı olarak, katılımcıların demografik bilgilerine ilişkin soruların yer aldığı form, Gürbüz ve diğ. (2012) ‘’Boş zaman engelleri-18’’ ölçeği, Oyar ve diğ. (2001) ‘’ Katılım motivasyon ölçeği’’ ve Tennant vd. (2007) tarafından geliştirilen, Keldal (2015) tarafından Türkçeye uyarlanan “Warwick-Edinburgh Mental İyi Oluş Ölçeği” kullanılmıştır. Elde edilen veriler SPSS 22 paket programı kullanılarak analiz edilmiş ve anlamlılık derecesi 0.05 olarak belirlenmiştir. Verilerin normallik dağılımları test sonuçlarına göre, normal dağılım gösteren verilerin analizlerinde bağımsız değişkenlerin ikili karşılaştırmaları için T testi, çoklu karşılaştırmaları için ise Anova analizi yapılmıştır.
CORPORATE UNIVERSITIES IN RUSSIA AS A DRIVER FOR COMPANIES’ STRATEGIC DEVELOPMENT
Authors:   Chelyabinsk State University, PLETNEV D.A. , KAZADAYEV M.S. ,   Chelyabinsk State University
Published: December 2022

The article substantiates the importance of developing the human potential of company employees for shaping the conditions for the transition to noonomics through the prism of such a phenomenon as a corporate university. The purpose of the article is to evaluate the role and functions of modern corporate universities in Russia. The article analyzes theoretical approaches to the role and place of corporate universities, analyzes the opinions of experts in the field of Russian corporate education on the role and functions of corporate universities, and describes three models of corporate universities in companies with different positioning of a person in strategic planning documents.
DIGITAL SKILLS DEVELOPMENT STRATEGY OF TRADITIONAL INDUSTRIAL REGION
Authors:   Ural State Economic University, KOKOVIKHIN A.YU.
Published: December 2022

This article presents some changes in regional skills strategies as a result of The Fourth Industrial Revolution. Theories of competences management and industrial development were used. Semi-structural interviews of Sverdlovsk Entrepreneurs and Industrialists Union members was done. Core competencies development in innovations and digitalization are the strategic aims for traditional industrial regions. Skills strategies needs in development of the basic digital knowledge, the communications and cooperation, the digital content production, the information security and digital development.
CITIZENS’ RIGHTS IN THE ECONOMIC SPHERE: DEBATABLE PROBLEMS OF THE CORRELATION OF PUBLIC AND PRIVATE INTERESTS
Authors:   Ural State University of Economics, GROMOVA N.S.
Published: December 2022

The article deals with the issues of correlation of public and private interests in the economic sphere as a debatable problem. The legal aspect of both the categorical-definitional distinction, and the practical-applicable one in the framework of protecting the rights of citizens and monitoring the observance of duties is highlighted. The immanent principle of the existence of rights and obligations in the sphere of economic activity is established As a result of the analysis of empirical data, it is concluded that individual and collective rights in the sphere of the economy are two parts of a single binary system. The dualistic approach to the theory of rights and their division into public and private in this matter seems to be schematic, not reflecting the nature of complex economic relations. It is proposed to consider the ratio of public and private interests in the economy as a complex category, taking into account the supra-sectoral nature of rights, freedoms and obligations, interconnected and interdependent not only by legal prerequisites, but also by social processes in the state.
RUSSIA: FROM STAGNATION TO SUSTAINABLE SOCIO-ECONOMIC GROWTH
Authors:   Academician of the Russian Academy of Sciences, AGANBEGYAN A.G.
Published: December 2022

Academician Aganbegyan analyzes the main socio-economic indicators of Russia over the past 30 years, identifies the negative trends that hinder sustainable economic development, and concludes that the factors that ensure legitimate socio-economic growth are not working in Russia. The author is convinced that in order to overcome stagnation and ensure sustainable socio-economic growth in Russia, it is necessary in the next 3–5 years to move to the accelerated growth of investment (10–15% annually) in fixed assets and in human capital, primarily in the “knowledge economy”, and then to conduct a number of major reforms. These include property reform, regional management reform, financial reform, and social reforms. According to the scientist, this will allow Russia to move to a new model of economy with predominantly private property, a civilized competitive environment and market pricing, a developed capital market and a social state.
SMALL AND MEDIUMSIZED ENTITIES IN THE AGRICULTURAL SECTOR, THEIR POTENTIAL FOR THE DEVELOPMENT OF RUSSIAN ECONOMY IN THE CONTEXT OF THE XXI CENTURY
Authors:   CIFAL RUS, SHIBAEV S.S.
Published: December 2022

The article considers prospects and potential for the development in Russia of non-industrial (extensive) poultry farming and cheese making. The experience of France in this sector is analyzed, the ways of development in Russia are suggested.
Investigación holística en la posmodernidad
Authors:   Universidad de São Paulo, Sánchez Janina M.
Published: December 2022

En esta reflexión tengo el objetivo de compartir meditaciones sobre teorías, conceptos y metodologías que en la posmodernidad componen las investigaciones científicas, internacionales y en el Perú, sobre problemas en la educación contemporánea. Empiezo discutiendo las tendencias políticas, económicas, filosóficas, sociológicas, antropológicas, que en algunos países llevaron a autores a clamar por el fin de la Modernidad y las teorías poscríticas asumieron rol central en la posmodernidad. A continuación, discuto sobre metodologías holísticas y comparto mi estudio hermenéutico de culturas, de posdoctorado, con título Mito hermenéutica de lo femenino en la antropología de la Educación: interculturalidad Brasil-Perú presentado en 2010 a la Facultad de Educación de la Universidad de São Paulo. Con la globalización y comunicación virtual de las últimas décadas, afloraron antiguas cuestiones que problematizan de nuevas maneras a la educación peruana, como la metodología de investigación, autonomía pedagógica, el racismo, diferencias entre clases sociales, corrupción, acoso sexual y moral. Considerando el legado positivista, neopositivista y, frente al capitalismo y neoliberalismo en la educación en el Perú, propongo que los investigadores sean protagonistas, intervengan en políticas públicas y logren el allin kawsay, para todos y todas.
Proyecto formativo como estrategia didáctica y aprendizaje de entornos virtuales en estudiantes universitarios, Huánuco-Perú 2022
Authors:   Universidad Nacional Hermilio Valdizán, Portocarrero Merino Ewer , Vega Tello Moulin Heysi ,   Universidad Nacional Hermilio Valdizán, Ascayo León Orlando ,   Universidad Nacional Hermilio Valdizán, Palacios Marte Alejandra Margarita Cielo ,   Universidad Nacional Hermilio Valdizán
Published: December 2022

El objetivo de este proyecto fue explicar cómo el “Proyecto Formativo: estudiantes universitarios para un contexto digital” mejora el aprendizaje de entornos virtuales. La propuesta responde a un estudio pre-experimental, pre y pos-test con un único grupo, conformado por 30 educandos del primer ciclo (ingresantes 2022), I semestre académico 2022-I, de las ocho carreras profesionales de la Facultad de Ciencias de la Educación, Universidad Nacional Hermilio Valdizán, Huánuco-Perú (UNHEVAL, Perú), en el que se aplicó el Proyecto Formativo: estudiantes universitarios para un contexto digital. El aprendizaje de entornos virtuales se evaluó a través de un cuestionario validado y confiable. Los resultados aportan que el promedio del puntaje alcanzado en el aprendizaje de entornos virtuales antes de la intervención formativa fue de 1,6 y después, de 4,1; encontrándose diferencias significativas en el pre y postest con p≤0,000. También, se encontraron diferencias significativas en las dimensiones aprendizaje de entornos virtuales, aprendizaje del Google Drive, aprendizaje de la plataforma Moodle, aprendizaje de la plataforma Quizizz, aprendizaje de la plataforma Classroom y aprendizaje del Google sites, todas con p≤0,000. Se concluye que la intervención a través del proyecto formativo: estudiantes universitarios para un contexto digital mejora significativamente el aprendizaje de entornos virtuales en estudiantes objeto de estudio.
DO INVESTORS’ REACTIONS TO ENVIRONMENTALLY FRIENDLY NEWS ANNOUNCEMENTS DIFFER ACROSS INDUSTRIES? A COMPARATIVE ANALYSIS OF JAPAN’S FOOD AND AUTOMOTIVE INDUSTRIES
Authors: Murashima Miho
Published: December 2022

Recently, investors’ growing awareness of environmental concerns has prompted many businesses to implement green policies and procedures. Investors’ reactions to firms’ environmental efforts vary across different industries. However, few empirical studies have addressed these differences, especially in Japan – the third-largest sustainable investor in the world. Using data from Japanese food and automotive industries, this research examined sector-specific differences in investors’ reactions to firms’ environmental performance, indicated by environmentally friendly news releases, using a short-term event study and Student’s t-tests. Results indicated that investors respond negatively to environmental activities in the food and automobile sectors, supporting neo-classical theory. The data also imply that, in Japan, industry variances have a neutral effect on short-term performance but a significant long-term effect. In addition, long-term investor responses to environmentally friendly news in the food sector are more unfavorable than in the automobile industry. This study has implications for policymakers and managers.
Endothelial dysfunction: developmental mechanisms and therapeutic strategies
Authors: Shcheblykin Dmitry V. , Bolgov Anton A. , Pokrovskii Mikhail V. , Stepenko Julia V. , Tsuverkalova Julia M. , Shcheblykina Olesya V. , Golubinskaya Polina A. , Korokina Liliya V.
Published: December 2022

Introduction: Every year the importance of the normal functioning of the endothelial layer of the vascular wall in maintaining the health of the body becomes more and more obvious.

The physiological role of the endothelium: The endothelium is a metabolically active organ actively involved in the regulation of hemostasis, modulation of inflammation, maintenance of hemovascular homeostasis, regulation of angio­genesis, vascular tone, and permeability.

Risk factors for the development of endothelial dysfunction: Currently, insufficient bioavailability of nitric oxide is considered the most significant risk factor for endothelial dysfunction.

Mechanisms of development of endothelial dysfunction: The genesis of endothelial dysfunction is a multifactorial process. Among various complex mechanisms, this review examines oxidative stress, inflammation, hyperglycemia, vitamin D deficiency, dyslipidemia, excess visceral fat, hyperhomocysteinemia, hyperuricemia, as well as primary genetic defect of endotheliocytes, as the most common causes in the population underlying the development of endo­thelial dysfunction.

Markers of endothelial dysfunction in various diseases: This article discusses the main biomarkers of endothelial dysfunction currently used, as well as promising biomarkers in the future for laboratory diagnosis of this pathology.

Therapeutic strategies: Therapeutic approaches to the endothelium in order to prevent or reduce a degree of damage to the vascular wall are briefly described.

Conclusion: Endothelial dysfunction is a typical pathological process involved in the pathogenesis of many diseases. Thus, pharmacological agents with endothelioprotective properties can provide more therapeutic benefits than a drug without such an effect.
Recent advances in the pharmacotherapy of osteoarthritis
Authors: Meera Muthu
Published: December 2022

Introduction: Osteoarthritis (OA) is a common debilitating disease affecting the geriatric population. Management of osteoarthritis is a challenge for orthopedicians because till date there has been no such drug that can completely cure the disease or at least retard/arrest the disease progression. In addition to the currently available treatment options for OA like NSAIDs, opioids, nutraceuticals (glucosamine sulphate and chondroitin sulphate), many new drugs are being discovered or repurposed for use in osteoarthritis. Most of these recent drugs aim at retarding the disease progression rather than providing just a symptomatic relief.

Materials and methods: All relevant articles regarding approved new drugs and pipeline drugs for osteoarthritis pub­lished between 2012–2021 were analysed. Those included animal studies as well as clinical trials. Some older articles were also referred to, provided they highlighted any significant data. The obtained data were analysed and compiled.

Results and discussion: Broadly the recent drugs for OA can be classified based upon their site of action as (i) drugs targeting articular cartilage, (ii) drugs targeting inflammation, (iii) drugs targeting the subchondral bone, and (iv) drugs for relieving pain. Ranging from in vitro studies to clinical trials, these drugs are in various phases of drug discovery. Early diagnosis of OA and its management with a drug that retards disease progression rather than prescribing just a symptom reliever is very much necessary in the current situation.

Conclusion: Need for new drugs for OA is increasing day by day. More number of clinical trials with larger sample sizes alone can satisfy the need of disease modifying drugs for OA. This review provides a deep insight into all the recent advances in the pharmacotherapy of osteoarthritis.

Graphical abstract:
Ilyocypris leptolinea Wang & Zhai, sp. nov., an ostracod (Ostracoda, Crustacea) from the late Quaternary of Inner Mongolia, northern China
Authors: Wang Qianwei , Horne David J. , Fan Jiawei , Wen Ruilin , Smith Robin J. , Wang Min , Zhai Dayou
Published: December 2022

Ilyocypris leptolinea Wang & Zhai, sp. nov. is described from late Quaternary sediments in central-eastern Inner Mongolia, northern China. The new species, which has a carapace shape and pitted surface typical of the genus, is characterised by double rows of fine, densely arranged marginal ripplets, separated by an inner list, along both anterior and posterior calcified inner lamellae in the left valve. Outline analysis and Principal Component Analysis indicate that its morpho-space overlaps with I. bradyi Sars, 1890, I. japonica Okubo, 1990, and I. mongolica Martens, 1991, which have living or fossil representatives in Inner Mongolia, but it is clearly discriminated from I. innermongolica Zhai & Xiao, 2013. Judging from the relatively coarse lithology dominated by silt and sand, and the lack of accompanying brackish-water ostracods, I. leptolinea Wang & Zhai, sp. nov. may have lived in a relatively shallow freshwater lake. It perhaps can be added to the list of species that went extinct during the Quaternary, but the timing and process of extinction await further investigation.
Italian natural history museums need specimen digitization and much more: a reply to Benvenuti et al.
Authors: Andreone Franco , Boero Ferdinando , Bologna Marco A. , Carpaneto Giuseppe M. , Castiglia Riccardo , Gippoliti Spartaco , Massa Bruno , Minelli Alessandro
Published: December 2022

We reply to the comments made by Benvenuti et al. (2022) about our paper on the Italian natural history museums and scientific collections and the need of a centralized hub and repository. While agreeing that digitization is a useful tool to valorize each museum and collection, we still believe that the suggestion of a centralized hub is valid and necessary. This would largely help in boosting coordination among museums, sharing personnel and resources, and in providing a place to deposit scientific collections that do not fit the scope of smaller museums.
The continuous is a jungle: the poetics of small intervals in indigenous Amazonia
Authors: Fausto Carlos
Published: December 2022

L’article développe une esthétique amazonienne qui s’exprime à travers un régime de petits intervalles, produisant de la variation au moyen de différences minimales. Il propose que cette esthétique soit non seulement à la base des arts visuels et verbaux-musicaux amazoniens, mais aussi de la perception et de l’engagement des peuples amazoniens envers le monde. Ce faisant, l’article inverse la priorité que Lévi-Strauss accordait au discret sur le continu dans la pensée amérindienne. Il suggère en outre que cette esthétique répond à la difficulté des non-indigènes à se rapporter aux expressions culturelles indigènes, ainsi qu’à leur environnement forestier.
Cuisiner avec Lévi-Strauss et les femmes enawenê-nawê : à la recherche de la condition humaine dans les subtilités de l’expérience quotidienne
Authors: Nahum-Claudel Chloe
Published: December 2022

Les femmes enawenê-nawê du Brésil central entretiennent des relations intimes avec un élément de leur culture alimentaire, le manioc amer et ses tubercules toxiques dans leur état cru. Contrôler le contact avec le manioc exige une attention constante de la part des membres d’un foyer (déplacement de la cuisine, précautions chamaniques, cuisine de mets particuliers etc.) puisque s’y trouvent souvent des personnes vulnérables aux effets néfastes de la plante, conçu comme un sujet féminin hyper-animé – ce sont les femmes qui ont leurs règles, leurs partenaires, des parents de nouveau-nés ou des adolescent(e)s. En suivant la voie frayée par Claude Lévi-Strauss et en me plongeant dans l’ethnographie de cette coexistence quotidienne nécessaire mais quelquefois perturbante, j’explore comment la condition humaine est « cuisinée », par des processus qui sont toujours à la fois pratiques et métaphysiques. Il s’agit précisément d’interroger la façon dont la pratique et l’expérience sensorielles de la vie s’articulent avec le mythe et l’idéologie la femme-manioc. L’intérêt de ce travail de Claude Lévi-Strauss sur la cuisine, est de se pencher sur les petites choses de l’expérience quotidienne et d’offrir des clés heuristiques faisant de ces petites choses – qui concernent souvent les femmes – des révélateurs de sens déterminants. Au moyen d’une relecture critique du « triangle culinaire » de Claude Lévi-Strauss, je propose donc une perspective féministe sur l’acte de cuisiner la condition humaine.
La guerre des symboles
Authors: Zaleskyi Dmytro , Lacour Laurence
Published: December 2022

L’auteur, analyste jungien ukrainien, nous expose certaines des conséquences psychiques de la guerre entre la Russie et l’Ukraine, au niveau individuel, dans la relation analytique ainsi qu’au sein des populations. Il insiste sur les vécus de distorsion temporelle, de variabilité et de polarisation des attachements et finalement sur les effets de confusion de la « zone grise » des états traumatiques. Il examine également les relations historiques complexes et agitées entre l’Ukraine et la Russie en remontant à leur période impériale, où elles ne formaient qu’un seul état. Il pointe les catastrophes collectives avec des millions de victimes survenues au xx e siècle, avec une politique secondaire d’amnésie, qui a empêché l’élaboration des traumatismes collectifs. Dans la période plus récente lui apparaît le mouvement d’émancipation et de différenciation du peuple ukrainien, dans une recherche de symbolisation authentique. C’est l’occasion d’un questionnement sur les usages et mésusages des symboles au niveau collectif et sur les dynamiques de constitution des sentiments d’identité nationale.
La contamination et Marguerite Duras
Authors: Fonseca Christiane
Published: December 2022

À son époque, Marguerite Duras a créé une véritable pandémie littéraire. Les uns, comme Alain Vircondelet, Xavière Gauthier, Colette Fellous, Yann Andréa l’ont portée aux nues, d’autres comme Philippe Sollers, Jean-Paul Sartre l’ont très mal supportée. Mais son œuvre a fasciné et fascine encore nombre de ses lecteurs qui sont comme imprégnés par ses romans poétiques, ravis par ses histoires d’amour, envoûtés par son écriture, comme contaminés par ce qu’elle appelle son « ombre interne » qui joue un rôle essentiel dans son écriture.
La typologie des organisations d’Eugène Enriquez, 1961-2022 : destins de ces analyses aujourd’hui
Authors: Chevetzoff Philippe , Maurin Souvignet Aurélie
Published: December 2022

Ce texte a été pensé comme une lecture commentée d’un article important d’Eugène Enriquez paru dans le n° 19 de la revue Connexions (1976). « Évaluations des hommes et structures d’organisations dans les entreprises » se donnait pour projet de mettre en évidence les concordances entre ce qui allait devenir, au fil des textes, une typologie des organisations et les modèles d’évaluations qui allaient devenir le point d’orgue de nos sociétés hypermodernes, néoliberales. Si l’intérêt d’Eugène Enriquez semble s’être progressivement détourné de son ambition typologique initiale, ces apports n’en restent pas moins très significatifs pour une analyse des problématiques contemporaines des organisations. Ce texte tente d’en montrer toute l’actuelle pertinence en même temps que les limites intrinsèques.
Les interventions institutionnelles d’hier et d’aujourd’hui
Authors: Kessar Zahia , Pinel Jean-Pierre
Published: December 2022

Après avoir rappelé quelques jalons de la modélisation des interventions institutionnelles proposée par Jean Claude Rouchy, l’article propose une analyse de ses concepts essentiels : la différenciation formation-intervention, la centralité de la notion de dispositif et la place de l’intervenant. Sont ensuite distingués les différents dispositifs d’intervention (analyse des pratiques, supervision, consultation, analyse d’institution), repérage princeps du modèle. Enfin dans une dernière partie, l’article montre les limites actuelles de la modélisation face aux bouleversements qui affectent le cadre et le métacadre des institutions. Le délitement des structures comme l’effacement des organisateurs d’équipes instituées exigent la construction de nouveaux cadres théorico-méthodo-logiques et la création de dispositifs pertinents. La question de l’intervention prend ainsi une très grande actualité et constitue un chantier interminable.
Espace transculturel intermédiaire. Une approche clinique des violences et des traumas et de leur prise en charge en groupes plurigénérationnels et multiculturels en Kanaky/Nouvelle-Calédonie
Authors: Thibouville Grégoire
Published: December 2022

Face aux écueils de la prise en charge individuelle de sujets en déshérence psychosociale et violents, il a fallu chercher quel pourrait être le dispositif le plus approprié pour rendre possibles l’émergence de ces traces psychiques, leur mise en mots et leur élaboration. À cette fin, il a fallu travailler à comprendre les effets dans les psychés , des plus âgés aux plus jeunes, à propos de la période actuelle, le plus souvent décrite comme celle d’une décolonisation inachevée, bien spécifique à cet archipel du Pacifique sud. Il a été question de trouver-créer un groupe de parole au sein de la protection judiciaire de l’enfance et de la jeunesse, avec le soutien du Sénat coutumier kanak. L’un des buts était d’ouvrir à quelques délinquants juvéniles un chemin qui les conduise dans une voie humanisante, leur procurant l’expérience et le goût d’un nouvel usage des paroles échangées avec d’autres. Le groupe que nous avons mis sur pied est pluriel quant aux appartenances culturelles, sociales et aux âges. Il donne la possibilité de se rencontrer dans un « Espace transculturel intermédiaire ». Il propose un palier accessible, permettant d’avancer sur la longue route d’une instauration narcissique et de la transformation des maux subis, traumatiques sans aucun doute.
L’analyse des pratiques professionnelles cliniques comme révélateur… de la défaillance de la « fonction miroir »
Authors: David Catherine
Published: December 2022

Dans les institutions de la mésinscription, les mutations actuelles impactent la tâche primaire, ses conditions de réalisation et les conditions de travail. Les pratiques d’interventions psychosociales s’en trouvent elles-mêmes interrogées sur différents registres, notamment celle des dispositifs analysants et de l’écoute. Elles conduisent à observer et éprouver combien se transforment les cadres institués intériorisés. Avec leur part de réalité et leur fonction de dépôt des représentations imaginaires, l’auteur postule que ces cadres, au-delà d’une fonction de contenance, occupent aussi une « fonction miroir ». En l’absence de travail psychique et de parole accompagnatrice, les transformations atteignent cette fonction touchant directement l’identité professionnelle. Le dispositif d’analyse des pratiques professionnelles cliniques s’en fait l’écho. Quel accueil et quelles transformations possibles pour soutenir et retrouver une disponibilité psychique à l’égard des publics ?
L’école, lieu de résilience en temps sociopolitiques troubles : approche psychodynamique en contexte tunisien post-révolution
Authors: Mokdad Zmitri Meriem
Published: December 2022

L’auteure, chercheure en psychologie clinique d’obédience groupanalytique, fait résonner ce statut avec celui d’enseignante de français langue étrangère auprès d’apprenants enfants et adolescents tunisiens. L’expérience, se déroulant en contexte tunisien post-révolution caractérisé par des mutations vertigineuses et une instabilité sociopolitique, lui permet d’observer comment la classe devient le lieu de manifestation spontanée des événements et des tensions environnantes et à quel point le climat scolaire reflète son homologue socioculturel. Elle montre, trois vignette à l’appui, comment se met en branle un processus de résilience socio-scolaire, s’élabore un matériel angoissant en s’alliant à l’apprentissage et elle plaide plus généralement pour l’importance d’un regard psychanalytique dans la réforme d’un système éducatif.
Rencontrer l’autre. La position des Galates dans les discussions avec Paul
Authors: Nicolet Valérie
Published: December 2022

Dans cette contribution, Valérie Nicolet revient sur quelques aspects de l’Épître aux Galates en prenant deux choses au sérieux : le fait que Paul se présente comme apôtre des nations, et la position des Galates au sein de l’empire romain. Elle inclut aussi une réflexion sur les rapports entre Juifs et non-Juifs dans l’Antiquité pour mieux comprendre pourquoi la position des Galates, critiquée par Paul, pouvait faire sens dans le contexte de ces communautés.
Une théologie de la beauté : variations autour de Paul sur la gratuité
Authors: Rohmer Céline
Published: December 2022

Pour penser la signification de la pratique de la théologie aujourd’hui, Céline Rohmer propose d’observer trois jeux d’échos entre épîtres pauliniennes et Évangile selon Matthieu (Ga 4,15-20 // Mt 5,13-16 ; Rm 7,15-21 // Mt 12,32b-37 ; Ga 6,7-10 // Mt 7,15-21). L’hypothèse défendue dans cette contribution est que l’auteur Matthieu porte les traces d’une compréhension paulinienne de la mise en œuvre de la transcendance dans la réalité de l’existence humaine qui en passe par une capacité d’émerveillement par la beauté. Paul et Matthieu à sa suite réfléchissent tous deux la présence agissante de Dieu à travers le réseau lexical de la beauté qu’ils prennent soin de distinguer du bien. En empruntant ce chemin pour dire Dieu, ils agissent en véritables poètes ouvrant la voie à une manière singulière de faire de la théologie.
La théologie chrétienne : grammaire subversive au service d’une cité provisoire
Authors: Singer Christophe
Published: December 2022

Si le travail théologique vise à donner un langage à l’événement de la foi, alors la théologie peut être définie avec Luther comme la « grammaire du mot Dieu ». Christophe Singer explore ce qu’implique cette définition quant à la possibilité d’une théologie fondée sur l’expérience et les Écritures, qui se garde pourtant du risque d’un confessionnalisme hermétique à tout dialogue et soit ainsi au service d’une existence humaine traversée par l’espérance du Royaume.
La psychanalyse au risque du « rêveur éveillé »
Authors: de Sinéty Jean-Marie
Published: December 2022

La psychanalyse au risque du « rêveur éveillé »- Réflexions théorico cliniques autour du sensoriel, de l’imaginaire et du rêve, dans un cadre renouvelé de la psychanalyse - convergences entre : hallucinatoire, rêve en séance, récits de rêves nocturnes.
Séduction et passion dans l’espace analytique. Un malentendu théorique
Authors: Matot Jean-Paul
Published: December 2022

Une dimension passionnelle peut prendre une place considérable dans un traitement psychanalytique. L’auteur l’envisage comme expression de noyaux mélancoliques en lien avec des zones traumatiques du psychisme. La réflexion poursuivie au décours d’une cure difficile l’amène à envisager deux temps dans l’élaboration et la transformation de cette dimension passionnelle. Dans un premier temps, il s’agit d’y survivre, c’est-à-dire à la fois d’éviter de s’y soustraire – dans la mesure où s’y engager avec la patiente est nécessaire pour accéder aux noyaux traumatiques – mais évidemment aussi de résister aux effets du clivage puissant qu’installe la sexualisation du mouvement passionnel. Dans un second temps, lorsque la dimension passionnelle s’est estompée, il s’agit pour l’analyste d’être encore davantage présent, d’éviter un retrait défensif, face à l’effraction des noyaux traumatiques, qui prennent souvent la forme d’un effondrement mélancolique. En effet, la douleur massive, intolérable, qui accompagne la résolution de la passion nécessite que l’analyse (re)trouve une capacité de s’engager davantage encore dans l’affrontement d’une véritable régression à la dépendance, et d’y répondre dans le registre de la préoccupation maternelle primaire.
Dérives de l’attraction, risque d’une séduction en court-circuit
Authors: Hours Armelle
Published: December 2022

C’est à partir d’une situation clinique que l’auteur examinera cette modalité du lien, où l’attraction est aussi forte que le risque accidentel est au rendez-vous. Destin de l’attraction trop forte, séduction en péril, la condition néotène de l’humain insiste. La tâche de l’analyste sera non seulement d’accueillir les mouvements souvent chaotiques, mais surtout de garder cette confiance dans la méthode, confiance qui peut bien évidemment s’éroder au contact de positions contre transférentielles périlleuses. Réintroduire par le jeu un écart dans ces contrées dévastées pourrait définir le projet de la cure, proche de l’ambition de l’artiste.
Le jour où l’empereur du Japon mangea de la viande. Les « banquets impériaux » comme construction politique à l’ère Meiji
Authors: Seizelet Éric
Published: December 2022

Cet article s’intéresse aux métamorphoses de la culture matérielle de la Cour impériale du Japon de Meiji, dont la présence du régime carné à la table de l’empereur et la nouvelle configuration des banquets impériaux induite par l’introduction au Palais de la cuisine occidentale figurent parmi les éléments les plus emblématiques de la transformation de l’image publique du souverain. Il cherche à démontrer qu’en s’appropriant les règles de l’étiquette de la Table en vigueur en Occident, le Japon s’efforce de s’aligner sur le modèle des Cours européennes et de prendre sa place parmi les « nations civilisées ». Dans le même temps, il met en valeur les banquets impériaux comme objet politique singulier, à la fois comme expression de la consolidation de la solidarité de la nouvelle élite dirigeante du pays, et comme mode de réception des étrangers, ainsi que les réticences que ces bouleversements ont parfois rencontrées.
L’archaïque et la médiation
Authors: Brun Anne
Published: December 2022

Cet article propose d’interroger la spécificité du langage des formes sensorielles et motrices dans le travail d’un matériau artistique comme la peinture, le modelage, et, plus largement, dans l’ensemble des médiations thérapeutiques artistiques. Cette écoute d’un matériel archaïque ouvre sur la compréhension des processus les plus archaïques dans l’approche psychanalytique des groupes. Cette perspective est différente de l’approche psychanalytique groupale traditionnelle, où le matériel clinique est souvent interprété sous l’angle de la fantasmatique groupale inconsciente, et des fantasmes originaires. Il s’agira donc de décrire les logiques des processus de transformation des formes sensori-motrices dans les médiations thérapeutiques groupales : l’émergence de ces formes qui correspondent à des sensations et à des mouvements relève d’une réactualisation de sensations hallucinées, porteuses de l’histoire des liens premiers à l’objet qui se scénarisent dans la rencontre du médium malléable.