bluuebunny/crossref_metadata_2025 huggingface dataset:
Choice Experiment Attributes Selection: Problems and Approaches in a Modal Shift Study in Klang Valley, Malaysia
Authors: Kaffashi Sara , Shamsudin Mad Nasir , Sidique Shaufique Fahmi , Bazrbachi Abdullatif , Radam Alias , Rahim Khalid Abdul , Adam Shehu Usman
Published: December 2015

Choice experiment (CE) is a questionnaire based method that the accuracy of research questionnaire determines the validity of the research outcomes. Attribute selection has a prime importance in every CE studies. If respondents do not understand or do not have preference for a certain attribute, the attribute non-attendance problem might happen that biases overall results of the research. Qualitative approaches such as literature review, focus group discussion, and in depth discussion commonly applied in CE researches. However, especially in the developing countries context where ethnical and cultural diversity is a challenge in conducting survey based questionnaires, qualitative methods are not sufficient in selecting attributes. Present study investigates the application of relative importance index (RII) in respondents’ preference for attributes in a modal shift study in Klang Valley, Malaysia. The 5 point Likert scale questions were employed to enhance respondents’ preferences for initial 24 selected attributes. The results of this study showed that from 24 pre-selected attributes, only 18 of them had RII>0.5 and could be included in the final CE design. The results of this study could help researchers to control for unobserved problems in selecting the attributes which could not be discovered through qualitative approaches.
Food Offer, Chronic Diarrhea and Preparedness to Alimentary Diabetes from the Second Year of Life Onwards
Authors: Ciampolini Mario , Borselli Lorenzo
Published: December 2015

Background: We have worked out an alimentary behaviour based on a meal- after -meal individual limit of energy intake (IHMP). We have then studied the energy intake, the pre-prandial blood glucose concentration (blood glucose, BG) and the body weight of a group of children with chronic not specific diarrhea. Finally we have added BG tolerance tests to clinically healthy adults in order to ascertain a possible association between IHMP and insulin sensitivity, should functional disorders or overweight problems arise.

Objective: With the present study we want to verify if mothers are capable of maintaining the IHMP and low pre-prandial BG levels in the eight years following the initial training, also in absence of diarrhea relapses. In adults the IHMP is associated to a good insulin sensitivity and this fact should be taken into consideration in order to reduce the increase of non - trasmissible deseases in the Western World.

Methods: We recruited children with not specific chronic diarrhea (bowel functional disorders) and selected randomly 53 mother-child pairs as the control group and 100 to be trained. Mothers were taught both how to recognise the correspondence between the individual manifestations of hunger and the BG concentration (Initial Hunger Meal Pattern, IHMP). The aim was to get low BG levels before each meal, and, thanks to the skill acquired, to stop the insulin resistance. The energy intake and the pre-prandial BG levels were reported in weekly diaries while the symptoms were recorded through structured interviews after 3 and 6 months and after 2,4,6,8 years.

Results: Energy intake reductions were significantly larger in trained than in control subjects at all 6 surveys after recruitment (P < 0.04 to < 0.0001) although growth was similar, Diarrhea and vomiting significantly dropped both in the trained group and in the control one compared to the beginning of the research. Larger reductions from base values in days with diarrhea in trained children (compared with controls) were found for the three initial months and in drug administration at the surveys after 2 years and after 8 years
Conclusion: Chronic non-specific diarrhea of the second year of life is associated with high energy intake and high pre-prandial BG for incomplete exhaustion of previous energy intake. In adults, this habit is associated with fattening/insulin resistance.
Ontbinding of opzegging van de huurovereenkomst wegens wanbetaling
Authors: Noordhuizen W.J.
Published: December 2015

Ontbinding of opzegging van de huurovereenkomst wegens wanbetaling

In deel 12 van de Studiereeks Nederlands-Antilliaans en Arubaans Recht (SNAAR), over het Nederlands-Caribisch huurrecht, werd opgemerkt dat een huurachterstand van ten minste drie maanden, waarbij op korte termijn geen concreet zicht bestaat op volledige afbetaling van het openstaande bedrag, doorgaans voldoende is om de huur te beëindigen. Een dergelijke vooropstelling komt men in de rechtspraak wel tegen. In de praktijk kan het door de verschillende procedures die aan ontruiming voorafgaan (doorgaans) meer dan drie maanden duren voordat de verhuurder weer over de woonruimte kan beschikken. Tijdens het wetgevingsproces zijn daarover in Sint Maarten vragen gesteld. Waar komt die driemaandentermijn vandaan? En is die (nog) wel gerechtvaardigd?
Instrumentos para avaliar a prática baseada em evidências na fisioterapia: uma revisão sistemática
Authors: Silva Anderson Martins da , Comper Maria Luiza , Costa Lucíola Da Cunha Menezes , Padula Rosimeire Simprini
Published: December 2015

Introdução: A Prática Baseada em Evidências pode ser definida como o uso de evidências científicas relevantes para orientar a tomada de decisão clínica e otimizar os resultados de saúde dos pacientes. Objetivos: Identificar, avaliar e descrever os instrumentos de avaliação da Prática Baseada em Evidências para fisioterapeutas, que estejam traduzidos e adaptados para o português brasileiro, por meio de uma revisão sistemática. Métodos: Realizaram-se buscas sistemáticas nas bases de dados eletrônicas: Embase, SciELO, CINAHL, PubMed e ERIC; e foram utilizados quatro grupos de termos de busca. Resultados: Dos 707 estudos identificados, apenas cinco foram selecionados para revisão de texto completo e, destes, nenhum preencheu os critérios de inclusão para a pesquisa. Conclusão: Os achados demonstraram a inexistência de instrumentos que avaliem a Prática Baseada em Evidências na Fisioterapia, traduzidos e adaptados para o português brasileiro.
Avaliação de software educativo na formação docente: articulando teoria e prática
Authors: Silva Ana Cristina Barbosa da , França Rozelma Soares de
Published: December 2015

Cada vez mais é necessário proporcionar, durante a formação inicial dos professores, momentos para que possam utilizar a tecnologia digital nos processos de ensino e de aprendizagem. Deste modo, este artigo apresenta os resultados de um projeto de extensão que promoveu a avaliação de softwares educativos por graduandos de licenciaturas em Química, Física, Matemática e Pedagogia, considerando a interface gráfica, aspectos pedagógicos e específicos das áreas supracitadas, a partir de critérios propostos em checklist. Os resultados evidenciam a compreensão da importância de avaliar os softwares educativos antes do uso com os estudantes, cultivando um senso crítico nos participantes do curso.
ABCÊ Bulir: Uma Proposta de Software Educacional para o auxilio no Processo de Alfabetização e Desenvolvimento Cognitivo de Crianças com Síndrome de Down
Authors: Rodrigues Michel S. , Félix Zildomar C.
Published: December 2015

As crianças com Síndrome de Down (SD) apresentam um relativo déficit cognitivo, ocasionando certo atraso na alfabetização. Considerando este contexto, o objetivo deste trabalho é evidenciar as características do processo cognitivo de crianças com SD, e propor o desenvolvimento de um software educacional com suporte a Interface Natural de Usuário, utilizandose, para isso, o dispositivo de hardware de detecção de movimentos da Microsoft, denominado Kinect.
Bem Mais que os Bits da Computação Desplugada
Authors: Bezerra Fábio
Published: December 2015

Aos alunos do curso de Licenciatura em Computação é fundamental que possuam elevada formação técnica em computação. Por outro lado, também é importante que esses alunos estejam à vontade com o universo do ensino e o contato com os aprendizes, pois atuarão na formaçãao de estudantes capazes de utilizar, compreender ou mesmo criar tecnologias para os computadores. Este trabalho relata a experiência que estudantes desse curso tiveram com a "Computação Desplugada" em uma escola pública. Essa experiência foi bem aceita pela escola e seus alunos, bem como para os licenciandos, que puderam vivenciar a rotina da escola e o ambiente da sala de aula.
Formação de Professores de Matemática: Avaliação de Recursos Digitais
Authors: Santos Fernanda M. , Barcelos Gilmara T. , Batista Silvia Cristina F.
Published: December 2015

Este artigo apresenta a análise de um estudo de caso com o qual se buscou contribuir para o desenvolvimento do senso crítico de licenciandos em Matemática, em relação à seleção e ao uso de tecnologias digitais como recursos pedagógicos. Nesse sentido, foi realizado um minicurso no qual foram utilizados um applet e uma apostila de atividades relacionadas ao mesmo. Tais recursos são direcionados a um tema de geometria analítica e foram elaborados pelas autoras deste artigo, por meio do software GeoGebra 5.0. Em geral, os licenciandos assumiram posturas críticas em relação aos recursos utilizados, avaliando-os positivamente, mas também propondo sugestões de melhorias.
GINTEC: a experiência de uma gincana tecnológica no contexto de um computador por aluno
Authors: Ribeiro Mônica Norris , Vieira Alessandro Carra , Geraldo Luciano Pereira
Published: December 2015

O presente trabalho objetiva relatar a experiência de uma gincana tecnológica - I GINTEC na rede pública municipal de ensino de Piraí /RJ, durante os meses de fevereiro e março de 2014. Essa iniciativa mobilizou alunos dos 8º e 9º anos de escolaridade do ensino fundamental proporcionando a integração de tecnologia, na forma de laptops educacionais, com o currículo escolar em atividades de produção de conteúdos digitais. A gincana, organizada em 2 etapas - escolar e interescolar- propôs tarefas que envolveram conhecimentos de robótica, mídias, manutenção de hardware e utilização de redes sociais, relacionados a temas transversais como meio ambiente, solidariedade, consumo e trabalho e temais locais.
Introdução à Programação e à Implementação de Processadores por Estudantes do Ensino Médio
Authors: Viel Felipe , Raabe André , Zeferino Cesar
Published: December 2015

Este trabalho descreve a iniciação de estudantes de ensino médio a programação de computadores, projeto de circuitos digitais e implementação de um processador com fins educacionais, sendo uma iniciativa para captação de egressos do ensino médio para cursos na área da computação, mais especificamente na Engenharia de Computação. O projeto avaliou o uso do processador BIP como um aporte para fomentar o desenvolvimento do pensamento computacional. O resultado apontou a viabilidade do programa proposto para pequenos grupos de estudantes e a vantagem de se apoiar nos recursos didáticos utilizados no primeiro ano dos cursos de graduação.
AdapterGame e suas Contribuições na Concepção de Jogos Educacionais
Authors: Santos Cristina Paludo , Bourscheidt Vanio Rodrigo Reichel
Published: December 2015

Este artigo apresenta uma solução computacional, referenciada como AdapterGame, que provê recursos para direcionar a concepção de jogos com adaptação de conteúdo. Seu uso no contexto educacional está atrelado à produção de materiais de apoio às práticas pedagógicas, promovendo subsídios para a disponibilização de jogos que possam ser utilizados em diferentes disciplinas e que abordem diversos conteúdos. Como forma de avaliar a aplicabilidade da solução proposta, contou-se com o apoio de educadores que vislumbraram pontos positivos e fizeram apontamentos importantes para a melhoria e extensão da solução proposta.
Perfil dos Professores Participantes de uma Pesquisa-Formação para o Uso Pedagógico do Laptop Educacional no Ensino de Ciências das Séries Iniciais e Educação Infantil
Authors: Gobara Shirley Takeco , Camilotti Dirce Cristiane , Avancini Régia
Published: December 2015

O presente trabalho relata as ações e apontamentos iniciais de uma pesquisa-formação que tem como objetivo geral desenvolver uma proposta de formação continuada para professores das séries iniciais e educação infantil para uso pedagógico do laptop educacional com ênfase no ensino de ciências. Trata-se de uma pesquisa qualitativa, na modalidade ação educacional, cujos resultados, etapa diagnóstica, evidenciaram uma prática tradicional e instrucionista e aponta a necessidade de atividades formativa para práticas inovadoras, contextualizadas e reflexivas que levem os professores à tomada de consciência de suas limitações e dificuldades no uso do laptop e da necessidade de atualizações metodológicas para o ensino de ciências.
Questions Today: Sistema m-learning como auxílio ao ensino da matemática
Authors: Sena Denise Maciel , Oliveira Elaine Harada T. de , Carvalho Leandro S. G. de
Published: December 2015

Este artigo apresenta um relato de experiência sobre a avaliação da aplicação do Questions Today – um aplicativo de aprendizagem móvel de apoio à aprendizagem de matemática – desenvolvido a partir da análise de aplicativos m-learning utilizados no ensino de matemática, encontrados na literatura. A aplicação aborda conteúdos específicos da matemática e avalia os alunos através de um exercício de fixação. O foco está no nível de ensino médio e a implantação foi realizada em uma escola pública estadual localizado na cidade de Manaus-AM, usando o celular como dispositivo móvel.
Tecnologias na Formação de Professores de Matemática: Uma Experiência na Iniciação a Docência
Authors: Basniak Maria Ivete
Published: December 2015

Discute-se neste trabalho a necessidade da formação de professores envolvendo tecnologias que supere a instrumentação em artefatos computacionais. Assumindo como pressupostos teóricos os trabalhos de Bittar (2011) de que o professor precisa integrar as tecnologias a sua prática pedagógica e de Bueno (2013) com destaque a seu caráter histórico-social, torna-se necessária uma formação que permita discussões e reflexões sobre possibilidades pedagógicas de uso dos computadores no ensino e aprendizagem dos conteúdos de matemática. Relata-se brevemente a experiência de trabalho junto ao subprojeto do PIBID: Tecnologias e Formação de Professores para o Ensino da Matemática da UNESPAR - campus de União da Vitória.
Um estudo de caso sobre a importância do uso de objetos de aprendizagem no ensino fundamental como apoio pedagógico
Authors: Nunes Felipe Becker , Moura Taciana Brito de , Hahn Cleonice Silvana Rodrigues , Maria Sandra Andrea Assumpção , Behar Patricia Alejandra
Published: December 2015

O uso da tecnologia na área educacional proporciona a utilização de diferentes recursos, que servem como suporte na prática pedagógica. Este artigo apresenta uma pesquisa que avalia a utilização dos Objetos de Aprendizagem como apoio na prática pedagógica. Um estudo de caso foi realizado em quatro escolas municipais, nas quais foram aplicados questionários com professores, coordenadores de laboratório de informática e com o setor tecnológico da Secretaria de Educação. Como resultados, foi verificado que os professores gostariam de utilizar este tipo de abordagem em sua prática pedagógica, porém existem fatores problemáticos que dificultam isto, como a falta capacitação tecnológica e melhores condições nas escolas.
Um Estudo Observacional sobre a Disciplina Introdutória de Programação
Authors: Guedes Elloá B.
Published: December 2015

As características particulares de cada contexto devem ser levadas em consideração no ensino de programação com o intuito de minimizar os altos índices de abandono e reprovação nestas disciplinas, comumente registrados na literatura. Levando isto em consideração, este trabalho apresenta os resultados de um estudo observacional realizado na disciplina introdutória de programação em uma universidade pública brasileira. Os resultados mostram que é necessário adotar estratégias de ensino diferenciadas com estudantes que já sofreram reprovaçõees prévias, e que não há evidências de que a utilização do português estruturado possa favorecer a aprendizagem de programação. Os resultados deste estudo auxiliam na identificação de problemas a partir de dados obtidos dos alunos e no desenvolvimento de estratégias para minimizá-los.
Applying the Method for Evaluation of Motivational Aspects on Karuchā Ships Invaders Educational Game with Brazilian Students of Japanese
Authors: Marciano Juvane Nunes , Miranda Erica Esteves Cunha de , Miranda Leonardo Cunha de
Published: December 2015

The increasing use of educational games in several learning contexts is noticed, and to reinforce this growth, it is very important to evaluate these tools in several of their aspects. An important aspect is the influence this kind of tool exercises in the learning process. This paper presents the evaluation of motivational aspects of Karuchā Ships Invaders educational game, through a method developed earlier by the authors, demonstrating that these aspects influence positively on the user's will to continue the learning and practice of Japanese language. The study was applied with Brazilian students of Japanese, and the results show that Karuchā Ships Invaders is a good educational tool for Japanese language learning.
Ética vital en Ortega y Gasset
Authors: Parra Ferreras José Antonio
Published: December 2015

La ética de Ortega y Gasset, en cuanto ethos o "sistema de reacciones morales", más que una reflexión filosófica sobre la moralidad o un "conjunto de normas ideales, es una actitud vital, profundamente arraigada en nuestra propia vida, comoparte constitutiva de la misma, cuya misión fundamental es iluminarnos y guiarnos en nuestro cotidiano quehacer para saber, en todo tiempo a qué atenernos.
La determinabilidad, de Fichte a Deleuze, o la Thathandlung como afirmación de la diferencia
Authors: Ferreyra Diego Julián
Published: December 2015

Este artículo se propone poner en relación el pensamiento de Johann Fichte con el de Gilles Deleuze, a partir del concepto de determinabilidad. El filósofo francés encuentra en Fichte uno de los antecedentes de su propio esfuerzo de alcanzar el punto de vista de la génesis de la experiencia a partir de la triplicidad de valores de la Idea: la determinación, lo indeterminado y lo determinable. Sin embargo, según Deleuze este enfoque se encuentra desnaturalizado en Fichte por un moralismo donde los tres valores aparecen fusionados. Intentaremos mostrar que, en lugar de traicionar el verdadero movimiento del pensamiento, el «moralismo» fichteano permite su concreción, justamente en los mismos términos en que Deleuze lo concibe. Señalaremos sólidas afinidades entre una filosofía de la diferencia -y no de la identidad-, y una fundada en una Thathandlung -y no en un sustrato-.
La ley de la Naturaleza como universal abstracto. Un estudio los principios morales de John Locke a la luz de su crítica a la idea de sustancia
Authors: Chumbita Joan Severo
Published: December 2015

El presente trabajo se propone estudiar la ley de naturaleza a la luz de la crítica que Locke realiza a la idea de sustancia. En este sentido, en primer lugar, se dará cuenta de los diversos contenidos de la ley de la naturaleza que aparecen en el corpus lockeano. En segundo término, a partir de esta pluralidad de formulaciones, se considerará si resisten la crítica que el propio Locke realiza a la idea de sustancia como esencia nominal, esto es, como definición genérica vaga e imperfecta que carece de ideas simples que la sustenten. Por último, se distinguirá esta crítica interna al concepto lockeano de la ley de la naturaleza de la crítica externa en términos de inconsistencia realizada por otros intérpretes.
La educación como fundamento del (mejor) régimen político en Aristóteles
Authors: Suñol Viviana
Published: December 2015

Tradicionalmente se le otorgó a Aristóteles un lugar secundario en la historia de la educación griega clásica. [..] aún hoy parece no reconocerse de manera suficiente la importancia que este tema tiene en su pensamiento (con Destrée 2013). La educación es la piedra fundamental de la ciencia (ético)-política aristotélica, pues a partir de ella se construye y se sostiene no solo el régimen ideal, sino todo régimen político (Política VIII 1), a la vez que resulta indispensable para que el hombre complete su naturaleza (Pol. VII 17 1337a1-3). El propósito del presente trabajo es mostrar que a pesar del carácter inconcluso de su tratamiento del tema, Aristóteles nos ofrece en Pol. VII 13-17 y VIII 1-2 elementos suficientes para reconocer la relevancia filosófica de la educación e identificar los aspectos más salientes de su teoría educacional.
A study on determining of macroinvertebrate biodiversity in water wells with stygobiont species findings
Authors: Ozkahya Pinar , Camur-Elipek Belgin
Published: December 2015

Although the  groundwater ecosystems are diversely populated habitats, it is believed that a lot of species wait for description in these special environments. But, increasing pollution in the world also affects groundwater ecosystems. Macroinvertebrates living as a subterranaean form in groundwaters play an important role in the purification of these habitats and provide usable water quality and they can be extinct before their description. Water wells which are man-made holes to get water from underground are very important environment for a lot of living things. They are made by the digging or drilling of groundwater in underground aquifers and sometimes stygobiont species occurs and can live in these habitats. The wells can create proper environments for living things. In this study, we investigated macroinvertebrate fauna of the  wells which are used for drinking/using in a  province at Turkish Thrace. For this aim, a total of 80 water wells were sampled during the years 2009–2010. Thus, it was aimed to determine the biodiversity on the macroinvertebrate fauna of these special habitats. As a  result, macroinvertebrates belonging to Annelida (Oligochaeta, Hirudinae), Arthropoda (Isopoda, Amphipoda, Diptera), and Mollusca (Gastropoda, Bivalvia) were reported as the first records in the wells of the studied area. Also, an eyeless stygobiont Amphipod species, Niphargus valachicus, was also found at two different water wells.
Editorial Board Thoughts: Library Analytics and Patron Privacy
Authors: Varnum Kenneth J.
Published: December 2015

Editorial Board Thoughts: Library Analytics and Patron Privacy
Automatic Format Recognition of MARC Bibliographic Elements: A Review and Projection
Authors: Butler Brett
Published: December 2015

A review and discussion of the technique of automatic format recognition (AFR) of bibliographic data are presented. A comparison is made of the record-building facilities of the Library of Congress, the University of California (both AFR techniques), and the Ohio College Library Center (non-AFR). A projection of a next logical generation is described.
Principles of Format Design
Authors: Avram Henriette D. , Rather Lucia J.
Published: December 2015

This paper is a summary of several working papers prepared for the International Federation of Library Associations (IFLA) Working Group on Content Designators. The first working paper, January 1973, discussed the obstacles confronting the Working Group, stated the scope of responsibility for the Working Group, and gave definitions of the terms, tags, indicator and data element identifiers, as well as a statement of the function of each.

The first paper was submitted to the Working Group for comments and was subsequently modified (revised April 1973) to reflect those comments that were applicable to the scope of the Working Group and to the definition and function of content designators. The present paper makes the basic assumption that there will be a SUPERMARC and discusses principles of format design.

This series of papers is being published in the interest of aerting the library community to intemational activities. All individual working papers are submitted to the MARBI interdivisional committee of ALA by the chairman of the IFLA Working Group for comments by that committee.
A Computer Output Microfilm Serials List for Patron Use
Authors: Saffady William
Published: December 2015

Library literature generally assumes that COM is better suited to staff rather than patron use applications. This paper describes a COM serials holdings list intended for patron use. The application and conversion from paper to COM are described. Emphasis is placed on the selection of an appropriate microformat and easily operable viewing equipment as conditions of success for patron use.
A Computer-Accessed Microfiche Library
Authors: Zimmerman R. G. J.
Published: December 2015

This paper describes a user-interactive system for the selection and display of pictorial information stored on microfiche cards in a computer-controlled viewer. The system is designed to provide rapid access to photographic and graphical data. It is intended to provide a library of photographs of planetary bodies and is currently being used to store selected Martian and lunar photography.
A Proposed Alternative Measure for Climate Change Potential
Authors: DeGroff F.
Published: December 2015

There currently exists no comprehensive metric to measure and value anthropogenic changes in carbon flux between all geospheric carbon sinks. We propose that changes in carbon residence time within geospheres be used as a metric to assess anthropogenic changes in carbon flux, and the term ‘carbon quality’ (cq) be used to describe such changes. Carbon residence time represents the inverse of carbon flux; as carbon flux increases, the corresponding cq will decrease, and vice versa.

Focusing on atmospheric carbon emissions as a measure of anthropogenic activity on the environment ignores the fungible characteristics of carbon that are crucial in both the biosphere and the worldwide economy. The ubiquitous carbon molecule enables the enormous diversity in the biosphere, as well as the widespread, strategic economic presence of carbon in the world economy. Focusing on a single form of inorganic carbon as a proxy metric for the plethora of anthropogenic activity and carbon compounds will prove inadequate, convoluted, and unmanageable. A broader, more basic metric is needed to capture the breath and scope of carbon activity.

We propose a logarithmic vector scale for cq to measure anthropogenic carbon flux. The distance between vector points, e.g. the starting and ending residence times, would represent the change in cq. A base-10 logarithmic scale would allow the addition and subtraction of exponents to calculate changes in cq.

As carbon moves between carbon reservoirs, the change in cq is measured as: cq = b (log10 [mean carbon residence time]) where b represents the carbon price coefficient for a particular country. For any country, cq measures the climate change potential for any organic carbon when converted to inorganic CO2, or to any lower residence time carbon state. The greater the carbon fees for a country, the larger the b coefficient would be, and the greater the import fees would be to achieve carbon parity on imports from countries with lower carbon fees.

By assessing embodied carbon within imports for carbon parity with domestic production, cq would eliminate the incentives to use spatial shifts in carbon emissions to avoid carbon fees. Similarity, cq would modulate the incentives to use temporal displacement of carbon emissions, such as with biomass or CCS, to reduce carbon fees.
Intelligent Cement Design: Utilizing Machine Learning Algorithms to Assure Effective Long-term Well Integrity
Authors: Shadravan Arash , Tarrahi Mohammadali , Amani Mahmood
Published: December 2015

Designing drilling fluids, spacers and cement slurries are all often done by trial and error in the laboratory. There are several test data that would not be used in this method and it is hard to digest a plethora of information for users and take intelligent and cost-effective decision to design a fluid with the desired properties. Therefore, trial and error method is considered to be time consuming, very costly and misleading. Today, there is a need for an intelligent system which uses all the available fluid design data stored in a database by which we can benefit from its insights for smart fluid designs. This predictive tool suggest a composition for drilling fluids, spacer fluid or cement slurry by implementing a machine learning algorithm on imported experimental data.

This paper investigates and implements a data-driven predictive tool which uses Gaussian Process Regression (GPR). GPR as a novel machine learning method considerably reduces the costs of testing, optimizes the material use, integrates available experimental data and eliminates the user bias. This practical nonlinear regression method fosters an efficient and fast prediction analysis which do not require including complex physics of the underlying intricate chemical fluid behavior while integrating all available data from different databases. GPR has exceptional advantages over traditional regression methods since it does not require a known form for regression function. Also its capability of determining estimation error and confidence interval is unique. This machine learning based tool offers comprehensive insights for intelligent fluid design and considerably reduces the experiment cost. This study showcases an example through which of GPR predicts rheological properties and helped engineers to maintain the fluid rheological hierarchy for better cement jobs and well integrity. Zonal isolation has the utmost importance for carbon sequestration projects.
Atenção Básica em Saúde Bucal: a experiência no curso de graduação
Authors: Motta Lara Jansiski , Gonçalves Patrícia Elaine , Lopes Marcia Cristina
Published: December 2015

Introdução: A participação do cirurgião‑dentista na atenção básica fomenta a importância da formação do profissional de clínica geral como generalista, bem como a necessidade do perfil de um profissional de saúde, com olhar holístico sobre o paciente. Relato de experiência: O presente artigo tem como objetivo relatar a experiência vivenciada na implantação da Clínica de Atenção Básica no curso de Odontologia (CAB). A análise reflexiva da experiência vivida se deu por meio do relato dos discentes participantes do projeto. Conclusão: A nova proposta de atendimento, uniu a teoria com as práticas técnicas tão importantes para o discente, permitindo que os discentes ampliassem os seus conhecimentos quando expostos à situações e processo de trabalho compatíveis com a realidade da comunidade e do serviço.
É possível estabelecer uma linha de tempo de reformas curriculares no curso de Medicina da Faculdade de Medicina do ABC?
Authors: Feder David
Published: December 2015

Introdução: A Faculdade de Medicina do ABC (FMABC) foi criada em 1969, em um período de grande expansão do ensino privado, com dois anos de ciclo básico, três anos de ciclo clínico e um de internato. Ao longo dos primeiros anos da Faculdade ocorreu um aumento progressivo do número de disciplinas e do tempo de internato para dois anos. Relato de experiência: Em 1999, iniciou‑se a discussão da reforma curricular, implantada em 2002, seguindo as Diretrizes Curriculares Nacionais (DCN) de 2001, visando a integração das disciplinas e maior consistência no futuro desempenho dos graduados. Houve a criação de espaços para conteúdos multidisciplinares,favorecendo a integração das diversas disciplinas, incluindo temas humanísticos. Com a inclusão da Faculdade no Programa Nacionalde Reorientação da Formação Profissional em Saúde (Pró‑Saúde), em 2015, acentuaram‑se as reformas curriculares, estimulando a integração do trabalho interdisciplinar e multiprofissional no sentido de aproximar academia, gestão, profissionais de saúde e comunidade. A partir de 2008, optou‑se pela visão sistêmica, pelos ciclos de vida e pela introdução do Objective Structured Clinical Examination (OSCE). A partir de 2013, modificações no currículo visaram a integração do conteúdo das disciplinas do ciclo básico em módulos e o início das disciplinas do ciclo clínico a partir do segundo ano, para que o internato tivesse a duração de dois anos e meio em 2016. Com a publicação das novas DCN, em 2014, novas modificações deverão ser obrigatoriamente introduzidas no curso. Conclusão: A reforma curricular é um processo contínuo que demanda reflexão e reestruturação constante do curso. A formação dos nossos graduados tem se mostrado adequada. As nossas avaliações externas nos tranquilizam de que estamos no caminho correto.
Oficina como um exercício de aprendizagem e de escuta colaborativa: o caso da revisão da Política Nacional de Promoção da Saúde
Authors: Guerra Vanessa De Almeida , Rezende Regiane , Rocha Dais Gonçalves , Silva Kleber Rangel , Akerman Marco
Published: December 2015

Introdução: O objetivo deste artigo é apresentar o relato da Oficina Sudeste como parte do processo de revisão da Política Nacional de Promoção da Saúde (PNPS). Relato de experiência: Utilizou‑se da análise documental dos relatórios produzidos durante o processo de revisão da PNPS, da leitura de artigos e notas de observação dos autores referentes às oficinas de sistematização e de consenso. Uma matriz da região sudeste foi construída com o intuito de reforçar o perfil regional considerando as realidades locais advindas do mundo do trabalho dos diversos atores envolvidos nas oficinas da região sudeste em seus respectivos espaços de prática e implementação de ações de promoção da saúde. A oficina regional possibilitou a participação democrática de atores locais compartilhando saberes e práticas. Ao identificar as ações locais de Promoção da Saúde, elencar os temas a serem trabalhados, por meio de eixos operativos, e, em consonância com os princípios e valores, os participantes da oficina puderam sistematizar as diretrizes que se aproximam dos determinantes e condicionantes de saúde de sua realidade. Conclusão: A metodologia desenvolvida na oficina aponta para a possibilidade de replicá‑la em diferentes dimensões, nos âmbitos estadual, municipal, distrital e local, proporcionando reflexões que podem tornar viva a nova PNPS.
Building accurate sequence-to-affinity models from high-throughput in vitro protein-DNA binding data using FeatureREDUCE
Authors: Riley Todd R , Lazarovici Allan , Mann Richard S , Bussemaker Harmen J
Published: December 2015

Transcription factors are crucial regulators of gene expression. Accurate quantitative definition of their intrinsic DNA binding preferences is critical to understanding their biological function. High-throughput in vitro technology has recently been used to deeply probe the DNA binding specificity of hundreds of eukaryotic transcription factors, yet algorithms for analyzing such data have not yet fully matured. Here, we present a general framework (FeatureREDUCE) for building sequence-to-affinity models based on a biophysically interpretable and extensible model of protein-DNA interaction that can account for dependencies between nucleotides within the binding interface or multiple modes of binding. When training on protein binding microarray (PBM) data, we use robust regression and modeling of technology-specific biases to infer specificity models of unprecedented accuracy and precision. We provide quantitative validation of our results by comparing to gold-standard data when available.
TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1
Authors: Etemadi Nima , Chopin Michael , Anderton Holly , Tanzer Maria C , Rickard James A , Abeysekera Waruni , Hall Cathrine , Spall Sukhdeep K , Wang Bing , Xiong Yuquan , Hla Timothy , Pitson Stuart M , Bonder Claudine S , Wong Wendy Wei-Lynn , Ernst Matthias , Smyth Gordon K , Vaux David L , Nutt Stephen L , Nachbur Ueli , Silke John
Published: December 2015

TRAF2 is a component of TNF superfamily signalling complexes and plays an essential role in the regulation and homeostasis of immune cells. TRAF2 deficient mice die around birth, therefore its role in adult tissues is not well-explored. Furthermore, the role of the TRAF2 RING is controversial. It has been claimed that the atypical TRAF2 RING cannot function as a ubiquitin E3 ligase but counterclaimed that TRAF2 RING requires a co-factor, sphingosine-1-phosphate, that is generated by the enzyme sphingosine kinase 1, to function as an E3 ligase. Keratinocyte-specific deletion of Traf2, but not Sphk1 deficiency, disrupted TNF mediated NF-κB and MAP kinase signalling and caused epidermal hyperplasia and psoriatic skin inflammation. This inflammation was driven by TNF, cell death, non-canonical NF-κB and the adaptive immune system, and might therefore represent a clinically relevant model of psoriasis. TRAF2 therefore has essential tissue specific functions that do not overlap with those of Sphk1.
Improvement on wear resistance property of polyurethane film by compositing plasma-treated multi-walled carbon nanotubes
Authors: Ogawa Daisuke , Nakamura Keiji
Published: December 2015

We investigated the effect of plasma-treated multi-walled carbon nanotubes (CNTs) that are composited into a polyurethane (PU) film. In this journal article, we especially focused on one of mechanical properties of PU film, the wear resistance, to find how the plasma-treated CNTs give contributions to improve the resistance. Our experimental results showed that plasma-treated CNTs enhanced the wear resistance, in particular, when the CNTs treated with the plasma that was made of nitrogen–oxygen mixture gas. Then, we made measurements with infrared absorption spectroscopy to find the possible causes of the improvement. The measurement showed that the surface of the CNTs treated with nitrogen–oxygen plasma had an indication of isocyanate group, which generally hardens PU film. The plasma likely attached the functional group on CNTs, and then the CNTs added extra wear resistance of a polyurethane film.
Aluminum matrix texture in Al–Al3Ti functionally graded materials analyzed by electron back-scattering diffraction
Authors: Watanabe Yoshimi , Sequeira Paulo D. , Sato Hisashi , Inamura Tomonari , Hosoda Hideki
Published: December 2015

Al matrix functionally graded materials (FGMs) with oriented Al3Ti platelets were fabricated by a centrifugal solid-particle method. The applied centrifugal forces were 30, 60, and 120G (units of gravity). The orientation and volume fraction gradients of the Al3Ti platelets within the samples were measured. Since a good lattice correspondence was reported for the close-packed directions and the close-packed planes between Al and Al3Ti, the Al matrix in the Al–Al3Ti FGMs fabricated by the centrifugal solid-particle method should have some texture. Al matrix texture was, therefore, analyzed by electron back-scattering diffraction (EBSD). Analysis of the resulting pole figures indicates a preferred orientation along the (200) plane for the Al matrix crystals. Furthermore, increasing the applied centrifugal force enhances the orientation effect. A correlation appears to exist between platelet orientation and the preferred texture of the Al matrix.
Development of a Taqman real-time PCR assay for rapid detection and quantification ofVibrio tapetisin extrapallial fluids of clams
Authors: Bidault Adeline , Richard Gaëlle G. , Le Bris Cédric , Paillard Christine
Published: December 2015

The Gram-negative bacteriumVibrio tapetisis known as the causative agent of Brown Ring Disease (BRD) in the Manila clamVenerupis(=Ruditapes)philippinarum. This bivalve is the second most important species produced in aquaculture and has a high commercial value. In spite of the development of several molecular methods, no survey has been yet achieved to rapidly quantify the bacterium in the clam. In this study, we developed a Taqman real-time PCR assay targeting virB4 gene for accurate and quantitative identification ofV. tapetisstrains pathogenic to clams. Sensitivity and reproducibility of the method were assessed using either filtered sea water or extrapallial fluids of clam injected with the CECT4600TV. tapetisstrain. Quantification curves ofV. tapetisstrain seeded in filtered seawater (FSW) or extrapallial fluids (EF) samples were equivalent showing reliable qPCR efficacies. With this protocol, we were able to specifically detectV. tapetisstrains down to 1.125 101bacteria per mL of EF or FSW, taking into account the dilution factor used for appropriate template DNA preparation. This qPCR assay allowed us to monitorV. tapetisload both experimentally or naturally infected Manila clams. This technique will be particularly useful for monitoring the kinetics of massive infections byV. tapetisand for designing appropriate control measures for aquaculture purposes.
Simulation of subgrid orographic precipitation with an embedded 2‐D cloud‐resolving model
Authors: Jung Joon‐Hee , Arakawa Akio
Published: December 2015

By explicitly resolving cloud‐scale processes with embedded two‐dimensional (2‐D) cloud‐resolving models (CRMs), superparameterized global atmospheric models have successfully simulated various atmospheric events over a wide range of time scales. Up to now, however, such models have not included the effects of topography on the CRM grid scale. We have used both 3‐D and 2‐D CRMs to simulate the effects of topography with prescribed “large‐scale” winds. The 3‐D CRM is used as a benchmark. The results show that the mean precipitation can be simulated reasonably well by using a 2‐D representation of topography as long as the statistics of the topography such as the mean and standard deviation are closely represented. It is also shown that the use of a set of two perpendicular 2‐D grids can significantly reduce the error due to a 2‐D representation of topography.
Cell‐free synthesis of isotopically labelled peptide ligands for the functional characterization of G protein‐coupled receptors
Authors: Joedicke Lisa , Trenker Raphael , Langer Julian D. , Michel Hartmut , Preu Julia
Published: December 2015

Cell‐free systems exploit the transcription and translation machinery of cells from different origins to produce proteins in a defined chemical environment. Due to its open nature, cell‐free protein production is a versatile tool to introduce specific labels such as heavy isotopes, non‐natural amino acids and tags into the protein while avoiding cell toxicity. In particular, radiolabelled peptides and proteins are valuable tools for the functional characterization of protein–protein interactions and for studying binding kinetics. In this study we evaluated cell‐free protein production for the generation of radiolabelled ligands for G protein‐coupled receptors (GPCRs). These receptors are seven‐transmembrane‐domain receptors activated by a plethora of extracellular stimuli including peptide ligands. Many GPCR peptide ligands contain disulphide bonds and are thus inherently difficult to produce in bacterial expression hosts or in Escherichia coli‐based cell‐free systems. Here, we established an adapted E. coli‐based cell‐free translation system for the production of disulphide bond‐containing GPCR peptide ligands and specifically introduce tritium labels for detection. The bacterial oxidoreductase DsbA is used as a chaperone to favour the formation of disulphide bonds and to enhance the yield of correctly folded proteins and peptides. We demonstrate the correct folding and formation of disulphide bonds and show high‐affinity ligand binding of the produced radio peptide ligands to the respective receptors. Thus, our system allows the fast, cost‐effective and reliable synthesis of custom GPCR peptide ligands for functional and structural studies.
Analysis of nucleotide diphosphate sugar dehydrogenases reveals family and group‐specific relationships
Authors: Freas Nicholas , Newton Peter , Perozich John
Published: December 2015

UDP‐glucose dehydrogenase (UDPGDH),UDP‐N‐acetyl‐mannosamine dehydrogenase (UDPNAMDH) andGDP‐mannose dehydrogenase (GDPMDH) belong to a family ofNAD+‐linked 4‐electron‐transfering oxidoreductases called nucleotide diphosphate sugar dehydrogenases (NDP‐SDHs).UDPGDHis an enzyme responsible for convertingUDP‐d‐glucose toUDP‐d‐glucuronic acid, a product that has different roles depending on the organism in which it is found.UDPNAMDHandGDPMDHconvertUDP‐N‐acetyl‐mannosamine toUDP‐N‐acetyl‐mannosaminuronic acid andGDP‐mannose toGDP‐mannuronic acid, respectively, by a similar mechanism toUDPGDH. Their products are used as essential building blocks for the exopolysaccharides found in organisms likePseudomonas aeruginosaandStaphylococcus aureus. Few studies have investigated the relationships between these enzymes. This study reveals the relationships between the three enzymes by analysing 229 amino acid sequences. Eighteen invariant and several other highly conserved residues were identified, each serving critical roles in maintaining enzyme structure, coenzyme binding or catalytic function. Also, 10 conserved motifs that included most of the conserved residues were identified and their roles proposed. A phylogenetic tree demonstrated relationships between each group and verified group assignment. Finally, group entropy analysis identified novel conservations unique to eachNDP‐SDHgroup, including residue positions critical toNDP‐sugar substrate interaction, enzyme structure and intersubunit contact. These positions may serve as targets for future research.

Enzymes

UDP‐glucose dehydrogenase (UDPGDH,EC 1.1.1.22).
Phthalocyanine‐Cored Star‐Shaped Polystyrene for Nano Floating Gate in Nonvolatile Organic Transistor Memory Device
Authors: Aimi Junko , Lo Chen‐Tsyr , Wu Hung‐Chin , Huang Chih‐Feng , Nakanishi Takashi , Takeuchi Masayuki , Chen Wen‐Chang
Published: December 2015

A novel non‐volatile organic memory device is developed based on an organic field effect transistor (OFET) with a dielectric layer of a four‐armed, star‐shaped polymer featuring a copper phthalocyanine (CuPc) core. The CuPc core unit of the star‐shaped polystyrene (CuPc‐PS4) self‐assembles to form aggregates via π–π interactions, which are isolated and dispersed in the polymer thin film. The OFET memory device employing CuPc‐PS4 shows significant hole‐trapping characteristics with a high memory ON/OFF current ratio of 107, long retention ability of over 104 s, and good endurance of more than 100 cycles, which is attributed to a flash‐type memory. The novel polymer design with CuPc core assemblies inside the polymer matrix is a promising candidate for nano floating gates in non‐volatile OFET memory.
A relatively mild skeletal ciliopathy phenotype consistent with cranioectodermal dysplasia is associated with a homozygous nonsynonymous mutation in WDR35
Authors: Smith Christopher , Lamont Ryan E. , Wade Andrew , Bernier Francois P. , Parboosingh Jillian S. , Innes A. Micheil
Published: December 2015

Ciliopathies are a class of clinically and genetically heterogeneous disorders characterized by deficits of the primary cilium, an important organelle for cellular signaling and development. Here we report on a patient from a consanguineous family presenting with renal cysts, short stature, distinctive facial features, missing teeth, brachydactyly, narrow chest, and abnormal ribs. His phenotype resembled a skeletal ciliopathy and the initial clinical differential diagnosis included Jeune thoracic dystrophy and cranioectodermal dysplasia. Due to the presence of parental consanguinity, a homozygous recessive mutation was the suspected cause and homozygosity mapping was used to direct candidate gene sequencing. WDR35, an intraflagellar transport protein previously associated with cranioectodermal dysplasia, the more severe short rib polydactyly syndrome type V and recently Ellis van Creveld syndrome, is present within a region of homozygosity and sequencing of all coding exons identified a novel homozygous nonsynonymous variant, p.Trp1153Cys. This variant affects a highly conserved tryptophan residue, is predicted to be deleterious, and is the most distal mutation yet reported in WDR35. This case expands the spectrum of phenotypes caused by WDR35 mutations, which we review herein. © 2015 Wiley Periodicals, Inc.