bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of pharmacist-led education session (ples) on quality of life among type 2 diabetes mellitus patients in Hospital Besut
Authors:   Department of Pharmacy, Hospital Besut, Jalan Pasir Akar, Kampung Tanduk, 22000 Jerteh, Terengganu, Wan Othman Wan Nusaibah , Ismail Nur Zulaikha ,   Department of Pharmacy, Hospital Besut, Jalan Pasir Akar, Kampung Tanduk, 22000 Jerteh, Terengganu, Wan Sallehuddin Wan Mohd Syahmi ,   Department of Pharmacy, Hospital Besut, Jalan Pasir Akar, Kampung Tanduk, 22000 Jerteh, Terengganu, Ramli Muhammad Haniff ,   Department of Pharmacy, Hospital Besut, Jalan Pasir Akar, Kampung Tanduk, 22000 Jerteh, Terengganu, Ramli Noorul Atiqah ,   Department of Pharmacy, Hospital Besut, Jalan Pasir Akar, Kampung Tanduk, 22000 Jerteh, Terengganu, Abdul Rashid Rabihah ,   Department of Pharmacy, Hospital Besut, Jalan Pasir Akar, Kampung Tanduk, 22000 Jerteh, Terengganu, Shafie Nur Aizahakiki ,   Department of Pharmacy, Hospital Besut, Jalan Pasir Akar, Kampung Tanduk, 22000 Jerteh, Terengganu
Published: February 2025

Type 2 Diabetes Mellitus (T2DM) is a chronic and progressive disease that has reached an epidemic level. To achieve a better quality of life among diabetic patients, patient education has become an essential role. Quality of life (QOL) is used as an important health outcome measure. Thus, this interventional study aimed to determine the effect of pharmacist-led education sessions (PLES) on QOL among T2DM patients in Hospital Besut and the association of sociodemographic factors with QOL. T2DM patients attending the Medical and Nephrology Clinic from July until November 2021 were recruited and randomised into the PLES and control groups. A guided questionnaire was used to evaluate their QOL in the satisfaction, impact and worry domains. The educational session was provided by the pharmacist via counselling, and all outcomes pre- and post-intervention were evaluated after a 3-month interval. Data were analysed using paired and independent t-tests, with p < 0.05 considered statistically significant. A total of 70 patients were enrolled in this study, with around half being female (52.8%) and a mean age of 58.6 ± 9.7. The increase in QOL after the intervention in the PLES group for all domains was significantly higher than that in the control group (p < 0.001). The mean QOL scores in the PLES group in terms of satisfaction, impact, and worry domains before intervention were 40.48 ± 14.1, 49.86 ± 17.84 and 45.14 ± 18.72, respectively, while the overall score was 44.44 ± 13.60. There was a significant improvement of QOL after PLES in satisfaction 31.43 ± 10.61 (p < 0.012), impact 38.86 ± 10.95 (p < 0.001), worry domain 36.76 ± 12.56 (p < 0.040) and an overall score of 35.25 ± 9.04 (p < 0.022). No significant improvement was observed in the control group (p = 0.447). There was no significant association between sociodemographic factors and QOL (P > 0.05). This study suggested that PLES had a positive impact on the quality of life of patients with diabetes.
HBE BETA-THALASSEMIA IS ASSOCIATED WITH IGA NEPHROPATHY
Authors:   Junior Resident, Department of Medicine, North Bengal Medical College, Susrut Nagar, Silliguri-734012, Dist- Darjeeling, West Bengal., Thakur Ayan , Bhandari Souvik ,   Junior Resident, Department of Medicine, North Bengal Medical College, Susrut Nagar, Silliguri-734012, Dist- Darjeeling, West Bengal., Rahman Obaidur ,   Junior Resident, Department of Medicine, North Bengal Medical College, Susrut Nagar, Silliguri-734012, Dist- Darjeeling, West Bengal., Pradhan Srijana ,   Junior Resident, Department of Medicine, North Bengal Medical College, Susrut Nagar, Silliguri-734012, Dist- Darjeeling, West Bengal., Ray Subhabrata ,   Assistant Professor, Department of Medicine, North Bengal Medical College, Susrut Nagar, Silliguri-734012, Dist- Darjeeling, West Bengal., Biswas Abhed ,   Assistant Professor, Department of Medicine, North Bengal Medical College, Susrut Nagar, Silliguri-734012, Dist- Darjeeling, West Bengal.
Published: February 2025

Thalassemia are a group of autosomal recessive inherited disorders of haemoglobin synthesis where in mutations of the -globin gene lead to various degrees of defective -chain production, an imbalance in -globin chain synthesis, ineffective erythropoiesis and anaemia. Improved survival in thalassaemic patients has led to the emergence of previously unrecognized complications, such as renal disease. Renal disease is considered the 4th cause of morbidity among patients with transfusion dependent thalassemia. IgA nephropathy (IgAN) is an immune complex-mediated glomerulonephritis, defined morphogically by the constant presence of dominant or co-dominant mesangial deposists of IgA and accompanied by avariety of histopathological lesions. It is the most common pattern of primary glomerulonephritis seen in the world and represents a significant cause of renal insufficiency in young adults. Here we report a case of 24 year old male known case of E beta thalassemia since his 8 years of age with IgA nephropathy.
A COMPARATIVE ANALYSIS BETWEEN ELECTROSURGICAL VERSUS HARMONIC DISSECTION OF GALL BLADDER FROM ITS BED IN LAPAROSCOPIC CHOLECYSTECTOMY
Authors:   Junior Resident, Department of General Surgery, GMC Patiala., Singh Ramneek , singla Bhawdeep ,   Junior Resident, Department of General Surgery, GMC Patiala., Chand Prem ,   Professor, Department of General Surgery, GMC Patiala., Singh Kahlon Paramjit ,   Assistant Professor Department of General Surgery, GMC Patiala., Sarve Trisha ,   Junior Resident, Department of General Surgery, GMC Patiala., Sood Itish ,   Junior Resident, Department of General Surgery, GMC Patiala.
Published: February 2025

Background: Various energy sources are now available like electrosurgical (monopolar and bipolar), ultrasonic shear devices, ultrasonic with bipolar and hydro dissection to separate gall bladder from liver bed. We conducted a study to compare electrosurgical and ultrasonic devices in dissection of gall bladder

Method: A prospective randomized controlled study was conducted involving 100 patients with gallstone disease. Patients were divided into two groups by the process of closed envelope randomization into electrosurgery (Group A) or ultrasonic dissection(Group B) groups. Both groups were compared for ease and feasibility of procedure, intra-operative complications during the procedure, operative time, conversion of laparoscopic to open cholecystectomy, post operative complication, comparison of pain, duration of stay in hospital and cost factor.

Observation: Various parameters were compared and it was observed that intraoperative bleeding was more in (28%) in the electrosurgery group in comparison to the harmonic group (8%). Injury to liver parenchyma was noticed less in the harmonic group (2%). Gall bladder perforation and bile leak were recorded more in electrosurgery patients (24%). Spillage of stone was 16% and 4% in Groups A and B respectively. Gut injury was observed in 2% of Group A in comparison to 0% in Group B. No CBD injury and postoperative complications were observed in either group. Post-operative hospital stay was lesser in Group B (1.98Ã‚Â±0.51days) than in Group A (2.24Ã‚Â±0.66 days). Postoperative pain was more in the electrosurgery group.

Conclusion: Dissection with harmonic scalpel in laparoscopic cholecystectomy is safe and technically feasible and may further improve surgical outcomes in terms of reduced duration of postoperative stay in hospital and pain with a significant reduction in intraoperative complications.
A RARE CAUSE OF MENORRHAGIA IN A YOUNG FEMALE : GLANZMANN THROMBASTHENIA(GT)
Authors:   PG Resident, Department of Medicine, North Bengal Medical College, Susrut Nagar, Silliguri- 70012, Dist - Darjeeling, West Bengal., Bhandari Souvik , Thakur Ayan ,   PG Resident, Department of Medicine, North Bengal Medical College, Susrut Nagar, Silliguri- 70012, Dist - Darjeeling, West Bengal., Rahaman Obidur ,   PG Resident, Department of Medicine, North Bengal Medical College, Susrut Nagar, Silliguri- 70012, Dist - Darjeeling, West Bengal., Pradhan Srijana ,   PG Resident, Department of Medicine, North Bengal Medical College, Susrut Nagar, Silliguri- 70012, Dist - Darjeeling, West Bengal., Ray Subhabrata ,   Assistant Professor, Department of Medicine, North Bengal Medical College, Susrut Nagar, Silliguri- 70012, Dist - Darjeeling, West Bengal., Biswas Abhed ,   Assistant Professor, Department of Medicine, North Bengal Medical College, Susrut Nagar, Silliguri- 70012, Dist - Darjeeling, West Bengal., Kumar Chakraborti Sumit ,   Professor, Department of Medicine, North Bengal Medical College, Susrut Nagar, Silliguri- 70012, Dist - Darjeeling, West Bengal.
Published: February 2025

Glanzmann thrombasthenia(GT) is a rare inheritated autosomal recessive bleeding disorder of platelet function caused by a defect in platelet membrane integrin Î±IIbÎ²3 ( glycoprotein IIb/ IIIa).This integrin is the platelet fibrinogen receptor andessential for platelet aggregation and hemostasis. The lack of resultant platelet aggregation in GT leads to mucocutaneous bleeding whose manifestation may be clinically variable, ranging from easy bruising to severe and potentially life- threatening hemorrhages. Here we report a 16 year old girl presenting with history of menorrhagia since her menarche, who was diagnosed as Glanzmann thrombasthenia.
AN UNUSUAL ASSOCIATION OF CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY: A CASE REPORT
Authors:   Junior Resident, Department of General Medicine, North Bengal Medical College., S. Mitra , A. Biswas ,   Assistant Professor, Department of General Medicine, North Bengal Medical College., S. Saha ,   Associate Professor, Department of General Medicine, North Bengal Medical College.
Published: February 2025

Distal Acquired Demyelinating Polyneuropathy (DADS), a variant of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is rarely associated with Monoclonal Gammopathy of Undetermined Significance. A case of quadriparesis is reported here, who was found to have DADS in background of MGUS IgA lambda. He was treated with intravenous Immunoglobulin and Azathioprine and showed good response. We report this case to sensitize the medical fraternity about the unusual association of CIDP with plasma cell dyscrasia.
Szemle: Váradi Monika Mária (szerk.): Migráció alulnézetből
Authors: Gábriel Dóra
Published: February 2025

A Migráció alulnézetből című tanulmánykötet egy magyarországi empirikus vizsgálatra épül, amely a helyiek élethelyzeteit, migrációjuk jellemvonásait, valamint a migrációs iparág komplex mechanizmusait elemzi. A kötet négy kutató (Váradi Monika Mária, Durst Judit, Virág Tünde, Németh Krisztina) összesen hét tanulmányát tartalmazza, amelyből kettő a romák migrációjával, öt pedig a vizsgált terepeken élők vándorlásának kérdéskörével foglalkozik.
Kohorsz ’18 Magyar Születési Kohorszvizsgálat. Másfél éves kutatási szakasz. Technikai riport
Authors: Szabó Laura , Boros Julianna , Fábián Ildikó , Kapitány Balázs , Kopcsó Krisztina , Ökrös Fruzsina , Spéder Zsolt , Veroszta Zsuzsanna
Published: February 2025

A kiadványt, kérjük, a következőképpen hivatkozza:Szabó Laura, Boros Julianna, Fábián Ildikó, Kapitány Balázs, Kopcsó Krisztina, Ökrös Fruzsina, Spéder Zsolt, Veroszta Zsuzsanna (2023). Kohorsz ’18 Magyar Születési Kohorszvizsgálat. Másfél éves kutatási szakasz. Technikai riport. Kutatási Jelentések 109. KSH Népességtudományi Kutatóintézet, Budapest. DOI: 10.21543/Kut.2023.109
Effects of Simulated Degradation Conditions on the Authentication of Fresh Quail Eggs Using a Miniaturized NIR Spectrometer and DD-SIMCA
Authors: M. Silva Karoline , S. Fernandes David Douglas , D. T. Moreira Edilene , G. P. Costa Fernando , S. Lyra Wellington , G. D. Diniz Paulo Henrique
Published: February 2025

This study developed a reliable and non-destructive analytical method for quality control
of quail eggs under simulated degradation conditions, including temperature variations and
UV radiation exposure, using a miniaturized near-infrared (NIR) spectrometer combined with
Data-Driven Soft Independent Modeling of Class Analogy (DD-SIMCA). A total of 336 quail
egg samples were evaluated, with 90 samples stored under optimal conditions for up to 14 days,
while the remaining 246 samples underwent controlled storage at temperatures of 30 and 40 °C
for 24, 48, and 72 h, and were exposed to UV irradiation for 2, 2.5, 3, 3.5, and 4 h. DD-SIMCA
models utilizing NIR spectra pre-processed with multiplicative scatter correction (MSC) and
Savitzky-Golay first derivative (SGD) achieved remarkable sensitivity and specificity of 100%
in the test set, demonstrating an effective and low-cost technology for ensuring the authenticity
of fresh quail eggs.
Mechanochemistry Metal-Free Synthesis and Molecular Modeling Study of 4-Arylamino-1,2-naphthoquinones by Csp2-Csp2 Bond Formation
Authors: O. Lima Filho Edson de , N. de Aguiar Antônio Sérgio , Borges Leonardo Luiz , Ferreira Vitor Francisco , de C. da Silva Fernando
Published: February 2025

The present work explores the mechanochemical synthesis and computational study of C–C
bond formation at the C-4 position of sodium 1,2-naphthoquinone-4-sulfonate (1, β-NQSNa) with
dialkylanilines (2a-2f). This is the first example of using mechanochemistry without transition
metal catalysts and solvents to produce 4-(4-(dialkylamino)phenyl)naphthalene-1,2-dione (3a-3f)
from symmetric and non-symmetric N,N’-dialkylanilines in good to moderate yields. Preliminary,
computational studies were conducted to explain the use of sterically hindered and less hindered
anilines, which caused variations in the yields of the analogous products, suggesting the formation
of π-π interactions between the anilines and the B ring of the naphthoquinone. Molecular modeling
was performed using density functional theory (DFT), employing the hybrid functional M06-2X
and the polarized valence triple-zeta basis set augmented for improved correlation (aug-cc-pVTZ).
Halal Lifestyle as A New Lifestyle in Modern Era: Demand Function Theory of Marshall and Ibn Taimiyah
Authors: Masruroh Nikmatul , Raziqi Ahmad , Hariyanto Al Furqon Dono
Published: February 2025

The Muslim community has grown to be the world’s largest population. Muslims have become a priority for business people and manufacturers who understand Muslim life patterns. Nowadays, manufacturers do not hesitate to use the halal label to reap huge revenues from Muslims. According to the GIE-report for 2019 to 2020, Muslim expenditure on the purchase of goods and services in six industries of food, finance, medicine, cosmetics, fashion, and travel and tourism has reached 2.2 trillion with 5.2% YoY growth from 1.8 billion Muslims worldwide. This draws a rosy picture of the development of the halal industry that Muslims have turned into a potential market. Products adhering to Islamic law are what manufacturers must consider having their goods sold well. The sharia trend has become a new lifestyle, particularly for millennials. The rise of Islamophobia is one of the reasons for the ascending trend of sharia-compliant lifestyles in the modern age. This paper highlights the sharia modes of consumption practiced by Muslims by employing literature review as a research methodology. Referring to the Marshallian demand function, the higher the demand, the higher the satisfaction, yet, even if it is labeled halal, the additional satisfaction decreases. This is in stark contrast to Ibn Taymiyah asserting that market demand depends on shifting preferences. Muslims are increasingly focused on the halal lifestyle due to ever-changing tastes based on economic reasoning.
Transaction Cost Analysis on The Financing of The Baitul Maal Wat Tamwil
Authors: Setyowati Ro'fah , Darwanto Darwanto , Adityawarman Adityawarman , Notolegowo Hantoro Ksaid
Published: February 2025

The emergence of Sharia microfinance institutions (S-MFIs) BMT has become a hope for micro, small and medium enterprises (MSMEs) pertaining to the improvement of access to capital loans, business, and welfare of MSME entrepreneurs. This study delves deeper into ex-ante and ex-post transaction costs of the BMT financing scheme at MSMEs from the BMT side and formulates strategies for optimizing BMT financing schemes for MSMEs. Constituting the largest contributor to the overall transaction costs at MSMEs, In a bid to reinforce the financing process, the efficiency of ex-ante transaction costs for drafting and ex-post transaction costs for designing and implementing the BMT’s governance is required.
Rethinking Human Development: Contributions of Mahbub Ul Haq, Amartya Sen, and Umer Chapra to Conventional and Islamic Indices
Authors: Jannah Nurul , Tarigan Azhari Akmal , Helmi Muhammad , Harahap Fasthabiqul Ambiya
Published: February 2025

Human development, as traditionally measured by the Human Development Index (HDI), focuses on key indicators such as life expectancy, education, and income. Developed through the contributions of Mahbub Ul Haq and Amartya Sen, the HDI aims to provide a comprehensive view of human well-being by assessing these core dimensions. However, the HDI has faced criticism, particularly for its limited scope in addressing the ethical and spiritual aspects of development. In response to these limitations, scholars like Umer Chapra have proposed alternative frameworks, including the Islamic Human Development Index (IHDI), which integrates aspects of maqasid al-shari'ah (objectives of Islamic law). This framework emphasizes five essential elements: religion, intellect, life, lineage, and wealth, aiming to align development with Islamic ethical values. While the IHDI offers an additional perspective on development by incorporating religious and ethical considerations, several studies have attempted to research IHDI implementations, and the process is still ongoing. Through a descriptive qualitative method, this study reflects the evolution of human development discourse. Over time, this discourse has expanded beyond material indicators to seek a more holistic construct of well-being, integrating ethical, spiritual, and social dimensions. By comparing these indices, the study highlights the ongoing efforts to develop frameworks that better capture the complexities of human flourishing and the multidimensional nature of well-being, and advocates for the adoption of more comprehensive indices that reflect both material and spiritual dimensions of human progress.
Reimagining Economic Wellbeing and Justice: The Wasaṭiyya Framework in Islamic Economics
Authors: Azzuhri Anggi , Fadhil Haidar Masyhur
Published: February 2025

This article explores the foundations and instruments of Islamic economics, with a focus on the wasaṭiyya (moderation) mindset. The concept of Iqtiṣād, which signifies balance and fairness, lies at the core of Islamic economic principles, as reflected in the Qur’ān and developed by scholars such as Al-Ghazālī, Ibn Khaldūn, and Bāqir Al-Ṣadr. Bāqir Al-Ṣadr positions Islamic economics as a middle path between capitalism and socialism, advocating an ethical system that promotes justice and sustainable growth. The study examines key financial instruments—zakāt, waqf, kharāj, jizya, and sukūk—which are designed to reduce poverty, promote wealth circulation, and ensure fair resource distribution. It also addresses challenges such as economic crises, regulatory failures, and societal greed, which threaten the sustainability of wellbeing. Through an analysis of primary Islamic texts and the works of major scholars, this article compares Islamic economic thought with capitalist and socialist models, highlighting its unique approach to wellbeing and justice. Modern scholarly contributions further enhance the discussion, providing insights into the practical applications of these principles today. Ultimately, the wasaṭiyya framework is shown to offer a balanced and resilient framework for addressing contemporary economic challenges, positioning Islamic economics as a viable alternative to conventional systems in the pursuit of human wellbeing and economic justice.
Response of discharge in the Upper Yellow River Basin to changing climate over the long time period (1850–2023)
Authors: Chen Ziyan , Su Buda , Fohrer Nicola , Huang Jinlong , Zhao Mengxia , Wen Shanshan , Jiang Tong
Published: February 2025

Previous studies addressing climate change impacts on discharge typically focused on limited periods, beginning with the earliest available observed data. This study extends the timeline to 1850–2023 using global climate models containing scenarios of both historical simulations (under climate change) and pre-industrial control (piControl, with greenhouse gases, aerosols, ozone, and solar irradiance fixed at 1850 levels) to drive hydrological models. Key findings include: (1) Basin average annual mean temperature has increased and precipitation has decreased from 1850 to 2023. With more pronounced climate change impacts in the late 20th and early 21st centuries, discharge in historical simulations decreased by up to 7% relative to piControl over the same period after 1970. (2) Climate change has increased discharge from March to May but decreased it in other months, particularly October, where historical simulations showed as much as a 25% decrease compared to piControl in recent decades. (3) Extreme high and low flows have decreased due to climate change, with decreases of up to 8 and 6%, respectively, after 2000, when compared to piControl. This study underscores the growing climate change impact on discharge, providing insights for disaster risk management and water resource planning in the Upper Yellow River (UYR).
Doble (y triple) pena para peruanos/as en Argentina en tiempos de dictaduras militares. Entre movilidades, deportaciones y desapariciones
Authors: Alvites Baiadera Angelica
Published: February 2025

Este artículo analiza la experiencia de peruanos/as en Argentina en tiempos de dictaduras militares (en la década de 1970), período en el que ambos países, tanto Argentina como Perú, controlaron y vigilaron las fronteras y la permanencia de «posibles subversivos». Se trabaja con una metodología cualitativa, para analizar entrevistas a informantes claves y un corpus documental. La conclusión fundamental es que las/los peruanos enfrentaron una doble (y, en algunos casos, triple) pena (Sayad, 2010). Esta se manifiesta en la articulación de las siguientes penalidades: (1) el castigo mediante la deportación de su país de origen; (2) la condena por su condición de no nacionales en Argentina; y (3) la sanción por un delito específico, vinculada a prácticas de «subversión».
ZARYS TEOLOGICZNYCH PODSTAW WTAJEMNICZENIA W EUCHARYSTIĘ
Authors: Krupka Aneta
Published: February 2025

Artykuł podejmuje temat teologicznych podstaw współczesnej katechezy związanej z sakramentem Eucharystii. Podstawę rozważań stanowi definicja Eucharystii, znajdująca się w 11. punkcie konstytucji dogmatycznej o Kościele Lumen gentium, ogłoszonej przez Sobór Watykański II. Zarysowane więc zostaje pojęcie Eucharystii jako ofiary, a także potrójne rozumienie kapłaństwa (chrystusowe, chrzcielne i służebne), nierozerwalnie związanego ze sprawowaniem Najświętszej Ofiary. Dalsza część artykułu rozwija soborowe określenia Eucharystii jako „źródła i szczytu życia chrześcijańskiego”, wskazując z jednej strony, na centralne miejsce tego sakramentu w życiu wierzących, a z drugiej strony ukazując go jako model życia i pobożności chrześcijańskiej.
Traços funcionais podem explicar uma maior vulnerabilidade de mamíferos à atropelamentos?
Authors:   , Sá Nayara Luana Rodrigues de Lima
Published: February 2025

Um dos grupos mais comprometidos pela alteração da paisagem são os mamíferos pois, além de apresentar uma fragilidade aos impactos ambientais, muitas de suas espécies são dependentes de áreas contínuas de habitat natural. Desta forma, as estradas podem vir a funcionar como barreira para seus deslocamentos. O presente trabalho teve por objetivo verificar se traços funcionais poderiam estar influenciando a vulnerabilidade de mamíferos ao atropelamentos em estradas localizadas ao redor de uma unidade de conservação, a Estação Ecológica do Seridó, no Rio Grande do Norte. Para isso, foram levantados dados de outubro de 2014 a outubro de 2016. Foi realizado o cálculo da taxa de mortalidade nos trechos selecionados, utilizando um modelo matemático simples de divisão, em seguida esse resultado foi utilizado como variável dependente e características funcionais das espécies de mamíferos atropelados como variáveis explicativas (massa corporal (g), comprimento corporal (cm), períodos de atividade (diurna, noturna, arrítmica), comportamento social (solitário ou grupo), guilda trófica (carnívoros, insetívoros, frugívoros, omnívoros, herbívoros), carniça (sim ou não), substrato de forrageamento (terrestre, terrestre-arbóreo), longevidade (anos), independência alimentar (semanas), obtidas por meio da literatura especializada. Os resultados mostram que a característica que apresentou uma relação significativa com os atropelamentos foi o tipo de substrato de forrageamento, onde as espécies que tem hábito de forrageio terrestre foram as mais atropeladas.
A relação umidade/proteína no camarão branco do pacífico litopenaeus vannamei como um parâmetro de identificação de fraude por adição de água
Authors:   , Oliveira Maria Érica da Silva
Published: February 2025

Considerando a flutuação de temperatura durante a cadeia do frio do pescado, onde o produto é submetido aos ciclos de congelamento e descongelamento, às práticas comuns de importação e exportação e a comercialização, o objetivo do presente estudo foi avaliar a eficácia de vários aditivos alimentares umectantes em L. vannamei após dois ciclos de congelamento e descongelamento e, ao mesmo tempo, verificar se a relação umidade-proteína de camarões frescos e congelados descongelados (tratados ou não com aditivos) pode ser útil na identificação de fraude econômica por adição de água. Amostras de camarão foram submetidas aos seguintes tratamentos: Controle (C - camarão fresco); T1 (água destilada); T2 (5% NaCl); T3 (tripolifosfato de sódio a 5% TPF); T4 (5% CARNAL 961); T5 (5% NP-30); T6 (5% de BRIFISOL 450); e T7 (5% BRIFISOL S5). Todas as soluções foram preparadas com água destilada (5ᵒC) e o tempo de imersão foi estabelecido em 60 min. As amostras foram divididas em dois grupos: GRUPO I – amostras que foram imersas e submetidas ao 1º congelamento (-35ºC/24 h), armazenamento (-35ºC/15 dias), 1º descongelamento (5ºC/24 h), 2º congelamento (-35ºC/ 24 h), armazenamento (-35ºC/15 dias) e 2º descongelamento (5ºC/24 h); GRUPO II – amostras que foram imersas novamente nos mesmos aditivos após o primeiro descongelamento, e prosseguiram ao 2º congelamento, armazenamento e descongelamento. Após cada etapa, foi determinado o rendimento (%) e realizadas as análises físico-químicas (umidade, proteína, sódio, fosfato, pH e capacidade de retenção de água - CRA). Os aditivos mostraram-se eficientes no ganho de peso e redução de perda de peso das amostras. Para os valores de umidade, proteína e relação umidade-proteína (RUP), verificou-se que houve diferença significativa (p<0.05) entre as amostras imersas em aditivos umectantes e a controle. A eficácia dos aditivos na CRA dependeu do número de ciclos de descongelamento. O maior valor de pH encontado foi de 8,62 (amostra tratada com NP-30), ultrapassando os limites estabelecidos pela legislação para camarão (7,85). Os maiores teores de fosfato foram encontados nas amostras tratadas com TPF, CARNAL-961, BRIFISOL 450 e BRIFISOL S5. Para todos as amostras tratadas com aditivos, houve aumento no teor de sódio. A análise de componentes principais (ACP) demostrou que as duas imersões e os diferentes aditivos utilizados foram determinantes para o comportamento das variáveis. Os resultados indicaram que a utilização dos aditivos umectantes na concentração e tempo sugeridos na pesquisa não foi capaz de exceder os limites da RUP estabelecidos pela legislação brasileira, demostrando que esse parâmetro deve ser reavaliado.
Hidratação enteral administrada em fluxo contínuo em asininos (equus asinus africanus) desidratados experimentalmente
Authors:   , Santos João Paulo Albuquerque dos
Published: February 2025

O presente estudo avaliou os efeitos de duas soluções eletrolíticas enterais de manutenção administradas por via nasogástrica em fluxo contínuo sobre os parâmetros fisiológicos, hematológicos, bioquímicos e urinário em asininos submetidos a desidratação. Para isso foram utilizados seis jumentos em um delineamento cross-over (6x2), mantidos em jejum hídrico e alimentar durante 36 horas, juntamente com administração de única dose de furosemida 2 mg kg-1 por via intravenosa, esperando-se desidratação discreta a moderada e posteriormente submetidos a 12 horas de hidratação enteral em fluxo contínuo. O protocolo de hidratação enteral não alterou os parâmetros fisiológicos, proporcionou aumento de
aproximadamente 11% do peso corporal, trouxe um aumento superior a 7% na circunferência abdominal, não acarretou no aumento da umidade nas fezes. Os resultados obtidos no ganho de peso e circunferência abdominal mostram que as soluções utilizadas foram efetivas em promover a recuperação da massa corporal dos animais. Porém a solução SEMalt mostrou-se mais efetiva em atingir a corrente sanguínea e causar maior hemodiluição. As soluções foram capazes de promover o suprimento de glicose, potássio e cálcio para os animais deste estudo.
Toxicidade reprodutiva da semente de neem (azadirachta indica A. Juss.) Em codorna (coturnix coturnix japônica linnaeus, 1758) macho: Características seminais, estudo histopatológico e Histomorfométrico do parênquima testicular
Authors:   , Góis Rayr Cezar de Souza
Published: February 2025

O neem (Azadirachta indica A. Juss.) é uma planta que foi introduzida no Brasil com o
objetivo de ser utilizada no desenvolvimento de um inseticida natural. Essa planta possui
várias atividades já descritas em literatura: inseticida, bactericida, fungicida, anti-inflamatório,
hepatoprotetor, anti diabético, vermífugo, carrapaticida e espermicida, além de provocar
efeitos negativos na reprodução de insetos e mamíferos, porém, essa ação negativa em aves,
ainda não foi descrita em literatura. O presente estudo objetiva avaliar a toxicidade
reprodutiva da semente neem em aves utilizando a codorna como modelo experimental. Para
isso, 50 codornas (Coturnix coturnix japônica Linnaeus, 1758) machos adultos foram
distribuídas em cinco grupos experimentais, sendo: T1, T2, T3 , T4 e T5, que receberam dieta
contendo respectivamente, 0%, 5%, 10%, 20% e 40% de semente incorporada à ração,
durante 60 dias. Após o período experimental, foi coletado sêmen do ducto deferente de cada
ave para análises espermáticas (concentração, motilidade, vigor, viabilidade e morfologia).
Para determinar os parâmetros biométricos, os testículos foram pesados em balança analítica e
mensurados com o auxílio de um paquímetro digital. A seguir, os testículos foram fixados em
solução de bouin e submetidos a confecção de lâminas histológicas coradas pela Hematoxilina
e Eosina (HE), sendo avaliadas por microscopia óptica para estudo das alterações
histopatológicas do parênquima testicular. Os cortes histológicos também foram avaliados
quanto aos parâmetros morfométricos testiculares: espessura da túnica albugínea, diâmetro
dos túbulos seminíferos e a altura do epitélio germinativo. As análises estatísticas foram feitas
pelo software SAS (1999) e teste-t de Student com 5% (P<0,05) de significância. Os valores
morfométricos reduziram significativamente nos T4 e T5 pois as aves dos referidos grupos
apresentaram degeneração acentuada das células do epitélio germinativo. As mensurações
histomorfométricas dos testículos mostraram que os animais do T4 e T5 apresentaram
aumento significativo (P<0.01) dos valores médios da espessura da túnica albugínea e
redução significativa dos valores do diâmetro dos túbulos seminíferos e da altura do epitélio
germinativo nos T4 e T5. Nos referidos tratamentos, houve redução significativa dos valores
da análise espermática. A adição de 20% e 40% de sementes de neem na dieta de codorna
durante 60 dias, foi capaz de interferir negativamente nos parâmetros biométricos testiculares,
causando um quadro degenerativo acentuado nas células germinativas, alterando os
parâmetros morfométricos testiculares e reduzindo a qualidade do sêmen.
Antenas de ferrita de níquel e zinco reconfiguráveis por campo magnético
Authors:   , Branco Henrique Emanuel Andrade Castelo
Published: February 2025

Os incentivos aos avanços para o setor de telecomunicações, em especial aos avanços tecnológicos relacionados aos dispositivos móveis, impulsionam e contribuem com as pesquisas relacionadas as antenas para fins de comunicação. Diante desse cenário, são apresentadas tendências voltadas à aplicação de antenas com parâmetros cada vez mais otimizados, a julgar, a busca por dispositivos cada vez menores e alto desempenho ou antenas mais eficientes para vasta gama de aplicações. Dessa maneira, o investimento em antenas de microfita ou mesmo materiais cerâmicos aplicados em antenas que sejam adequadas para mesma função desempenhada no ramo de telecomunicações e eletromagnetismo aplicado, são atrativos ao desenvolvimento tecnológico. Os materiais cerâmicos que possuem como características uma alta constante dielétrica, dispõem de vantagens, como boa adequação nas faixas de micro-ondas e alta eficiência de irradiação, pois as perdas dielétricas das cerâmicas são baixas, quando comparadas a materiais como a fibra de vidro que é muito comum na confecção de antenas de microfita. Sendo assim, a combinação dessas vantagens tornam os dispositivos cerâmicos apropriados nos projetos de antenas que os utilizem como substrato de elemento patch irradiante ou mesmo como o próprio elemento irradiante, determinados como antenas ressoadoras dielétricas (DRA). Nesta dissertação é feito um estudo bibliográfico sobre as antenas de microfita e as antenas DRA, que contextualizam o objetivo deste trabalho como sendo realizar o desenvolvimento de antenas de microfita sob substrato de ferritas de níquel e zinco, com frequência de ressonância projetada para 5,8 GHz, e estudar o comportamento reconfigurável de parâmetros, na medida em que serão aplicados campos magnéticos externos aos dispositivos em questão. Após essa etapa, a pesquisa apresentou o projeto de antenas DRA, onda as estruturas foram excitadas pela técnica de acoplamento por abertura na mesma frequência de projeto, validados pela parametrização e comparação dos resultados computacionais e experimentais que tanto as antenas patches e as antenas DRA foram submetidas
Revisiting the Role of Long Non-coding RNA PSMA3-AS1 in Human Cancers: Current Evidence and Future Directions
Authors: Yang Jingjie , Liu Kexing , Chen Lihan , He Haodong , Li Tongtong , Li Li , Li Xiaolan , Yuan Chengfu
Published: February 2025

Long non-coding RNAs (lncRNAs) refer to RNA molecules that exceed 200 nucleotides in length.
While lncRNAs do not possess the capacity to encode proteins, they play crucial roles in gene expression, chromatin
remodeling, and protein relocation. PSMA3 antisense RNA 1 (PSMA3-AS1) is a newly discovered lncRNA
located on human chromosome 14q23.1. Convincing evidence shows that it acts as a tumor-promoting factor
in several forms of human cancers. Moreover, high expression of PSMA3-AS1 is linked to poor clinical
and pathological features and adverse prognosis in eight types of cancer. The molecular mechanisms of PSMA3-
AS1 are diverse and complex. Existing evidence demonstrates that PSMA3-AS1 is activated by two transcription
factors, PAX5 and YY-1, and influences cancer cell growth, metastasis, apoptosis, drug resistance,
oxidative stress, and autophagy by acting as a competing endogenous RNA, activating signaling pathways, directly
interacting with RNA or proteins, as well as participating in the epithelial-mesenchymal transition process.
Therefore, PSMA3-AS1 holds promise as a biomarker for cancer detection and prediction, as well as a
novel therapeutic target. This review explores the expression features, biological roles, potential mechanisms,
and clinical significance of PSMA3-AS1 in various human cancers and provides directions for future research.
Efficient Synthesis, Characterization, and Molecular Docking Studies of Some Novel Benzothiazolamine-Based Terephthaloyl Bisthioureas and Investigation of their Potent Antioxidant Activities
Authors: Naseem Muhammad , Rafique Hummera , Roshan Sadia , Malik Fouzia Perveen , Tayyab Muhammad
Published: February 2025

Variously substituted benzothiazolamines were prepared and employed as starting material to synthesize
some new benzothiazolamine-based bis-thiourea derivatives, such as N3, N3’-bis(6-substituted benzothiazolyl)
terephthaloyl-bis(thioureas). Molecular modeling of all the synthesized compounds was carried out to
check the interactions of all the bis-thiourea ligands inside the active pocket of enzyme 3MNG in comparison to
competitive antioxidant inhibitor DTT (1,2-dithiane-4,5-diol). The antioxidant activities of all the synthesized
compounds were determined using a DPPH radical assay performed by standard methods. Benzothiazole-based
bis-thiourea derivatives exhibited significant potent antioxidant properties.
Kojic Acid - A Blossoming Scaffold of Biological Significance: An Overview of Synthesis, Properties, and Biological Applications
Authors: Bhardwaj Arpana , Saroha Bhavna , Bishnoi Poonam , Kumar Gourav , Kumar Ramesh , Kumar Suresh
Published: February 2025

Kojic Acid (KA) is an oxygen-based heterocycle of natural occurrence and is chemically known as 5-
hydroxy-2-(hydroxymethy1)-4H-pyran-4-one. This review has been designed to lighten up the various biological
potentials, including the tyrosinase inhibition potential and depigmenting action of KA and its derivatives.
KA has very interesting physical and chemical properties and has many applications in the medicinal and cosmetic
industries, like antimicrobial, antifungal, antitumor, anti-inflammatory, and depigmentation activities.
Despite its medicinal importance, KA possesses a fascinating structure with multiple reactive centers, making it
valuable in various chemical transformations. Therefore, a variety of KA derivatives have been/may be prepared
with improved stability and with more effective and interesting biological activities than KA itself. Here, in this
review, we have briefly described the biological activities of some potent KA derivatives with a brief introduction
to the physical and chemical properties of KA. This review would bridge the gap between basic research
and applied science, offering value to both scientific and industrial communities.
Influence of DNA Copy Number Aberrations in ABC Transporter Family
Genes on the Survival of Patients with Primary Operatable Non-Small Cell
Lung Cancer
Authors: Tsyganov Matvey Mikhailovich , Ibragimova Marina Konstantinovna , Rodionov Evgeny Olegovich , Frolova Anastavia Alekseevna , Tsydenova Irina Aleksandrovna , Lutzkaya Elizaveta Andreevna , Miller Sergey Viktorovich
Published: February 2025

Purpose:

Previous research has shown, that ABC transporters gene expression level
can predict the efficacy of therapy. However, other mechanisms of gene activity are rarely considered, especially in non-small cell lung cancer (NSCLC). Thus, the purpose of the work was
to assess chromosomal aberrations of all 49 ABC transporters genes and the expression levels
of some ABC genes, as well as their correlation with survival.

Materials and Methods:

The surgical material of 104 patients with NSCLC was used in this
study. Treatment included surgery and 3 courses of adjuvant chemotherapy with “platinum
doublets”. DNA and RNA were isolated from the samples, followed by microarray analysis to
assess the expression and chromosomal aberrations (deletions and amplifications) of ABC
genes.

Results:

Metastatic-free survival (MFS) was higher with ABCC1, ABCC2, and ABCG1 hypoexpression at a statistically significant level (p=0.01). The presence of deletion in ABCB1 correlates with 100% MFS (p=0.001). The survival rates with ABCG1 amplification are not higher
than 45% (p<0.0001). ABCA11 deletion is associated with a low MFS rate (38%) versus 91%
with normal copy number (p=0.006). ABCB9 analysis showed opposite results, with survival
rates of 55% and 91% in the presence of amplification and normal copy number, respectively
(p=0.006). ABCC subfamily genes showed a similar result in the presence of amplification,
where ABCC3 and ABCC10 account for 64% and 60% survival, respectively (p=0.005, p=0.01)

Conclusion:

Thus, not only expression but also chromosomal aberrations were found to be associated with patient survival. These findings could be a
potential marker of metastatic-free
survival.
Therapeutic Potential of Simvastatin: Cellular Mechanism, Binding Energetics, and Resistance Developments
Authors: Verma Shristy , Malviya Rishabha , Sundaram Sonali , Srivastava Saurabh , Sridhar Sathvik Belagodu , Rab Safia Obaidur , Singh Deependra Pratap
Published: February 2025

Statins are a class of hypolipidemic agents that have been shown to promote osteogenic
differentiation through enhanced alveolar bone recovery, inserted osseointegration, and cartilage
regeneration. This review uses Molecular Docking (MD) simulations and additional Computer-
Aided Drug Design (CADD) methods to present the state of the art in statin therapy. Furthermore,
several studies have shown that factors such as limited overall absorption, metabolism in the first
pass, and systemic side effects are among those that affect the oral administration of statins. In addition,
these variables include susceptibility to efflux mechanisms, drug permeability, dissolution
percentage, aqueous solubility, initial metabolism, and pre-systemic metabolism. Additionally examined
are the pharmacokinetics of the statin and in vivo mechanisms of action. As a result of the
numerous problems associated with the consumption of statins, including their low total bioavailability,
first-pass metabolism, low aqueous solubility, and systemic adverse reactions, a non-oral
mode of administration was looked into for this crucial and primary class of pharmacokinetic
agents. However, to optimize bioavailability and minimize side effects, more research is required.
Atrial Cardiomyopathy-associated Arrhythmia and the Impact of Sirtuin
Signaling Pathway: A Narrative Review
Authors: Lee Wei-Chieh , Fang Hsiu-Yu , Chen Huang-Chung , Lin Yu-Sheng , Chen Mien-Cheng , Liu Ping-Yen
Published: February 2025

With the aging population on the rise, the higher prevalence of atrial tachyarrhythmia is
emerging as a significant healthcare concern. Atrial fibrillation (AF) stands out as the most common
atrial tachyarrhythmia, potentially leading to adverse outcomes, such as stroke, heart failure (HF), or
conduction dysfunction. Furthermore, AF may serve as a manifestation of underlying atrial cardiomyopathy, which forms the structural and electrical substrate for arrhythmias. Atrial cardiomyopathy
is characterized by structural and electrical remodeling of the atria, resulting in impaired mechanical
function and the generation of arrhythmias. Sodium-glucose cotransporter 2 inhibitors (SGLT2is)
have recently emerged as a novel medical treatment for HF. Their use has been associated with a
reduced incidence of new-onset AF, potentially attributing to the improvement of atrial cardiomyopathy. This effect is achieved through the regulation of glucose utilization and energy consumption
within the myocardium. It is worth noting that the sirtuin signaling pathway plays a crucial role in
regulating energy consumption, especially in the presence of increased oxidative stress and fibrosis.
This pathway also exerts a significant influence on various cardiovascular diseases. This review aims
to provide a comprehensive summary of the involvement of the sirtuin signaling pathway in cardiovascular diseases, with a specific focus on atrial cardiomyopathy and AF and the potential molecular
mechanisms of SGLT2is in the sirtuin signaling pathway and atrial cardiomyopathy.
Updates on the Pathogenesis and Therapeutic Approaches for Hereditary
Hemorrhagic Telangiectasia
Authors: Yadav Alka , Shabani Zahra , Dhaliwal Jasneet Kaur , Schmidt Annika , Su Hua
Published: February 2025

Hereditary Hemorrhagic Telangiectasia (HHT), also known as Osler-Weber-Rendu syndrome, is a rare and inherited vascular disorder characterized by the development of arteriovenous
malformations (AVMs) in various organs and telangiectasia (small AVM) in the mucocutaneous. The
majority of HHT patients have haploinsufficiency of genes involved in the transforming growth factor-beta (TGF-β) signaling pathway, including endoglin (ENG), activin receptor-like kinase 1 (ALK1,
also known as ACVRL1), or SMAD4. Active angiogenesis is also required for telangiectasia and
AVM development. Anti-angiogenic strategies have been tested in patients and animal models extensively. However, the exact mechanisms for telangiectasia and AVM development remain unclear. In
this review, we discussed several important advances in the past 10 years in understanding HHT
disease mechanisms and in therapeutic development.
Development and Validation of Bioenhancer-based Phospholipid Complexes with Exceptional Immunomodulatory and Antioxidant Potential
Authors: Sharma Samisha , Dwivedi Jyotsana , Dwivedi Monika , Kumari Madhu , Yadav Reenu , Khatoon Sayyada , Rawat Ajay Kumar Singh
Published: February 2025

Background:

Combination therapy with polyphenol-rich natural spices has gained acceptance
as a proactive approach for modulating human health owing to the COVID-19 pandemic.
However, bioavailability is a significant hurdle in determining the actual potential of any herbal
drug.

Aim & Objective:

To improve the absorption of herbal drugs and to enhance their ability to affect the
immune system, phospholipid complexes were developed for accommodating Curcumin with extracts
of commonly found dietary spices like Piper longum, Piper nigrum, and Zingiber officinale
aiming to have an effective immunomodulatory phytoformulation subduing the bioavailability limitation
of Curcumin and delivery hurdle of phytoextracts for combination therapy. Since combination
therapy with polyphenol-rich natural spices had surfaced as an effective mode of immunomodulation,
phospholipid complexes were designed for encapsulating polyphenol-rich natural spices and
Curcumin together and assessed for the most efficient phospholipid complexes with improved invitro
therapeutic outcomes.

Method:

A quick and easy procedure for assessing the developed formulation using High-
Performance Thin-Layer Chromatography (HPTLC) was developed. Antioxidant potential was
measured by DPPH and Lipid peroxidation. Further immunomodulation was assessed in macrophages
by NO inhibition assay and phagocytosis capacity.

Result:

The results showed that polyherbal phospholipid complexes exerted 2-fold enhanced antiradical
properties (DPPH radical scavenging and inhibition of lipid peroxidation) as compared to
Curcumin and significant inhibition of ROS in H2O2-induced human macrophages. Moreover, these
polyherbal formulations were more effective in promoting macrophage proliferation, inhibiting LPSinduced
NO production in macrophages, and enhancing phagocytosis in a dose-dependent manner.

Conclusion:

Thus, phospholipid complexes offer a practical approach for developing nutraceuticals
with augmented bioactivity of herbal components.