bluuebunny/crossref_metadata_2025 huggingface dataset:
Activation of pH-Sensing Receptor OGR1 (GPR68) Induces ER Stress Via the IRE1α/JNK Pathway in an Intestinal Epithelial Cell Model
Authors: Maeyashiki Chiaki , Melhem Hassan , Hering Larissa , Baebler Katharina , Cosin-Roger Jesus , Schefer Fabian , Weder Bruce , Hausmann Martin , Scharl Michael , Rogler Gerhard , de Vallière Cheryl , Ruiz Pedro A.
Published: January 2020

Proton-sensing ovarian cancer G-protein coupled receptor (OGR1) plays an important role in pH homeostasis. Acidosis occurs at sites of intestinal inflammation and can induce endoplasmic reticulum (ER) stress and the unfolded protein response (UPR), an evolutionary mechanism that enables cells to cope with stressful conditions. ER stress activates autophagy, and both play important roles in gut homeostasis and contribute to the pathogenesis of inflammatory bowel disease (IBD). Using a human intestinal epithelial cell model, we investigated whether our previously observed protective effects of OGR1 deficiency in experimental colitis are associated with a differential regulation of ER stress, the UPR and autophagy. Caco-2 cells stably overexpressing OGR1 were subjected to an acidic pH shift. pH-dependent OGR1-mediated signalling led to a significant upregulation in the ER stress markers, binding immunoglobulin protein (BiP) and phospho-inositol required 1α (IRE1α), which was reversed by a novel OGR1 inhibitor and a c-Jun N-terminal kinase (JNK) inhibitor. Proton-activated OGR1-mediated signalling failed to induce apoptosis, but triggered accumulation of total microtubule-associated protein 1 A/1B-light chain 3, suggesting blockage of late stage autophagy. Our results show novel functions for OGR1 in the regulation of ER stress through the IRE1α-JNK signalling pathway, as well as blockage of autophagosomal degradation. OGR1 inhibition might represent a novel therapeutic approach in IBD.
Noasaurids are a component of the Australian ‘mid’-Cretaceous theropod fauna
Authors: Birch Sienna A. , Smith Elizabeth T. , Bell Phil R.
Published: January 2020

The diversity of Australia’s theropod fauna from the ‘mid’-Cretaceous (Albian–Cenomanian) is distinctly biased towards the medium-sized megaraptorids, despite the preponderance of abelisauroids in the younger but latitudinally equivalent Patagonian theropod fauna. Here, we present new evidence for the presence of ceratosaurian, and specifically abelisauroid, theropods from the Cenomanian Griman Creek Formation of Lightning Ridge, New South Wales. A partial cervical vertebra is described that bears a mediolaterally concave ventral surface of the centrum delimited by sharp ventrolateral ridges that contact the parapophyses. Among theropods, this feature has been reported only in a cervical vertebra attributed to the noasaurid Noasaurus. We also reappraise evidence recently cited against the ceratosaurian interpretation of a recently described astragalocalcaneum from the upper Barremian–lower Aptian San Remo Member of the upper Strzelecki Group in Victoria. Inclusion of the Lightning Ridge cervical vertebra and Victorian astragalocalcaneum into a revised phylogenetic analysis focused on elucidating ceratosaurian affinities reveals support for placement of both specimens within Noasauridae, which among other characters is diagnosed by the presence of a medial eminence on the ascending process of the astragalus. The Lightning Ridge and Victorian specimens simultaneously represent the first noasaurids reported from Australia and the astragalocalcaneum is considered the earliest known example of a noasaurid in the world to date. The recognition of Australian noasaurids further indicates a more widespread Gondwanan distribution of the clade outside of South America, Madagascar and India consistent with the timing of the fragmentation of the supercontinent.
Home-based cognitive training in pediatric patients with acquired brain injury: preliminary results on efficacy of a randomized clinical trial
Authors: Corti Claudia , Urgesi Cosimo , Poggi Geraldina , Strazzer Sandra , Borgatti Renato , Bardoni Alessandra
Published: January 2020

Cognitive rehabilitation may compensate for cognitive deficits of children with acquired brain injury (ABI), capitalizing on the use-dependent plasticity of a developing brain. Remote computerized cognitive training (CCT) may be delivered to patients in ecological settings, ensuring rehabilitation continuity. This work evaluated cognitive and psychological adjustment outcomes of an 8-week multi-domain, home-based CCT (Lumosity Cognitive Training) in a sample of patients with ABI aged 11–16 years. Two groups of patients were engaged in five CCT sessions per week for eight weeks (40 sessions). According to a stepped-wedge research design, one group (Training-first Group) started the CCT immediately, whereas the other group (Waiting-first Group) started the CCT after a comparable time of waiting list. Changes after the training and after the waiting period were compared in the two groups. Both groups improved in visual-spatial working memory more after the training than after the waiting-list period. The Training-first group improved also in arithmetic calculation speed. Findings indicate that a multi-domain CCT can produce benefits in visual-spatial working memory, probably because, in accordance with previous research, computer games heavily tax visuo-spatial abilities. This suggests that the prolonged stimulation of the same cognitive ability may generate the greatest benefits in children with ABI.
Gut microbiota plasticity is correlated with sustained weight loss on a low-carb or low-fat dietary intervention
Authors: Grembi Jessica A. , Nguyen Lan H. , Haggerty Thomas D. , Gardner Christopher D. , Holmes Susan P. , Parsonnet Julie
Published: January 2020

While low-carbohydrate and low-fat diets can both lead to weight-loss, a substantial variability in achieved long-term outcomes exists among obese but otherwise healthy adults. We examined the hypothesis that structural differences in the gut microbiota explain a portion of variability in weight-loss using two cohorts of obese adults enrolled in the Diet Intervention Examining The Factors Interacting with Treatment Success (DIETFITS) study. A total of 161 pre-diet fecal samples were sequenced from a discovery cohort (n = 66) and 106 from a validation cohort (n = 56). An additional 157 fecal samples were sequenced from the discovery cohort after 10 weeks of dietary intervention. We found no specific bacterial signatures associated with weight loss that were consistent across both cohorts. However, the gut microbiota plasticity (i.e. variability), was correlated with long-term (12-month) weight loss in a diet-dependent manner; on the low-fat diet subjects with higher pre-diet daily plasticity had higher sustained weight loss, whereas on the low-carbohydrate diet those with higher plasticity over 10 weeks of dieting had higher 12-month weight loss. Our findings suggest the potential importance of gut microbiota plasticity for sustained weight-loss. We highlight the advantages of evaluating kinetic trends and assessing reproducibility in studies of the gut microbiota.
Southeastern Asia fall armyworms are closely related to populations in Africa and India, consistent with common origin and recent migration
Authors: Nagoshi Rodney N. , Htain Ni Ni , Boughton Duncan , Zhang Lei , Xiao Yutao , Nagoshi Benjamin Y. , Mota-Sanchez David
Published: January 2020

The discovery of fall armyworm, a native of the Western Hemisphere, in western Africa in 2016 was rapidly followed by detections throughout sub-Saharan Africa, India, and most recently southeastern Asia. This moth pest has a broad host range that threatens such important crops as corn, rice, millet, and sorghum, creating concern for its potential impact on agriculture in the Eastern Hemisphere. Although genetic data suggest populations sampled in Africa and India originate from a recent common source, it is not known whether this is the case for populations in southeastern Asia, nor whether the subgroup with a preference for rice and millet is present in the region. This study found through comparisons of genetic markers that the fall armyworm from Myanmar and southern China are closely related to those from Africa and India, suggesting a common origin for these geographically distant populations. The results are consistent with a single recent introduction into the Eastern Hemisphere followed by rapid dispersion. The molecular similarities include discrepancies between the genetic markers that brings into question whether the subpopulation most likely to be a threat to rice and millet is present in significant numbers in Asia.
Tuneable interplay between atomistic defects morphology and electrical properties of transparent p-type highly conductive off-stoichiometric Cu-Cr-O delafossite thin films
Authors: Lunca-Popa Petru , Botsoa Jacques , Bahri Mounib , Crêpellière Jonathan , Desgardin Pierre , Audinot Jean-Nicolas , Wirtz Tom , Arl Didier , Ersen Ovidiu , Barthe Marie-France , Lenoble Damien
Published: January 2020

Off-stoichiometric copper chromium delafossites demonstrate the highest values of electric conductivity among the p-type transparent conducting oxides. Morphological and structural changes in Cu0.66Cr1.33O2 upon annealing processes are investigated. Chained copper vacancies were previously suggested as source of the high levels of doping in this material. High resolution Helium Ion Microscopy, Secondary Ion Mass Spectrometry and Transmission Electron Microscopy reveal a significant rearrangement of copper and chromium after the thermal treatments. Furthermore, Positron Annihilation Spectroscopy evidences the presence of vacancy defects within the delafossite layers which can be assigned to the Cu vacancy chains whose concentration decreases during the thermal process. These findings further confirm these chained vacancies as source of the p-type doping and suggest that the changes in electrical conductivities within the off-stoichiometric copper based delafossites are triggered by elemental rearrangements.
Cathepsin S activation contributes to elevated CX3CL1 (fractalkine) levels in tears of a Sjögren’s syndrome murine model
Authors: Fu Runzhong , Guo Hao , Janga Srikanth , Choi Minchang , Klinngam Wannita , Edman Maria C. , Hamm-Alvarez Sarah F.
Published: January 2020

Autoimmune dacryoadenitis and altered lacrimal gland (LG) secretion are features of Sjögren’s syndrome (SS). Activity of cathepsin S (CTSS), a cysteine protease, is significantly and specifically increased in SS patient tears. The soluble chemokine, CX3CL1 (fractalkine), is cleaved from membrane-bound CX3CL1 by proteases including CTSS. We show that CX3CL1 is significantly elevated by 2.5-fold in tears (p = 0.0116) and 1.4-fold in LG acinar cells (LGAC)(p = 0.0026) from male NOD mice, a model of autoimmune dacryoadenitis in SS, relative to BALB/c controls. Primary mouse LGAC and human corneal epithelial cells (HCE-T cells) exposed to interferon-gamma, a cytokine elevated in SS, showed up to 9.6-fold (p ≤ 0.0001) and 25-fold (p ≤ 0.0001) increases in CX3CL1 gene expression, and 1.9-fold (p = 0.0005) and 196-fold (p ≤ 0.0001) increases in CX3CL1 protein expression, respectively. Moreover, exposure of HCE-T cells to recombinant human CTSS at activity equivalent to that in SS patient tears increased cellular CX3CL1 gene and protein expression by 2.8-fold (p = 0.0021) and 5.1-fold (p ≤ 0.0001), while increasing CX3CL1 in culture medium by 5.8-fold (p ≤ 0.0001). Flow cytometry demonstrated a 4.5-fold increase in CX3CR1-expressing immune cells (p ≤ 0.0001), including increased T-cells and macrophages, in LG from NOD mice relative to BALB/c. CTSS-mediated induction/cleavage of CX3CL1 may contribute to ocular surface and LG inflammation in SS.
Publisher Correction: Building a DNA barcode library for the freshwater fishes of Bangladesh
Authors: Rahman Md. Mizanur , Norén Michael , Mollah Abdur Rob , Kullander Sven O.
Published: January 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Ion hydration and association in aqueous potassium tetrahydroxyborate solutions
Authors: Zhu Fayan , Yamaguchi Toshio , Yoshida Koji , Zhang Wenqian , Liu Hongyan , Zhou Yongquan , Fang Chunhui
Published: January 2020

The overlapping peaks are clearly investigated in the form of pair distribution functions using the EPSR program.
An electronic enzyme-linked immunosorbent assay platform for protein analysis based on magnetic beads and AlGaN/GaN high electron mobility transistors
Authors: Wang Jin , Gu Zhiqi , Liu Xinsheng , Zhao Lei , Peng Huoxiang , Li Jiadong
Published: January 2020

The AlGaN/GaN high electron mobility transistor (HEMT) biosensors have the characteristics of high sensitivity, stability and fast response in the detection of biomolecules.
Integrated microsystems for the in situ genetic detection of dengue virus in whole blood using direct sample preparation and isothermal amplification
Authors: Yoo Hyun Jin , Baek Changyoon , Lee Min-Ho , Min Junhong
Published: January 2020

An in situ detection system compatible with LAMP that can detect the dengue virus and discriminate between its serotypes in the whole blood.
Gold nanostars as a colloidal substrate for in-solution SERS measurements using a handheld Raman spectrometer
Authors: Mahmoud Ahmed Y. F. , Rusin Casey J. , McDermott Mark T.
Published: January 2020

Colloidal gold nanostars for rapid and in-solution SERS measurements of methimazole in urine using a handheld Raman spectrometer.
Breast cancer analysis by confocal energy dispersive micro-XRD
Authors: Escudero Rodrigo O. , Cabral María C. , Valladares Mariana , Franco María A. , Perez Roberto Daniel
Published: January 2020

In this work, the confocal energy dispersive micro-XRD technique has been employed to efficiently study differences between normal and malignant carcinomas in breast tissues.
Simulation of a phenobarbital molecularly imprinted polymerization self-assembly system and its adsorption property
Authors: Liu Junbo , Zhao Wensi , Wang Guangyu , Tang Shanshan , Jin Ruifa
Published: January 2020

Theoretical study of a phenobarbital molecularly imprinted polymerization self-assembly system and its adsorption properties.
Docking of tetra-methyl zirconium to the surface of silica: a well-defined pre-catalyst for conversion of CO2 to cyclic carbonates
Authors: Al Maksoud Walid , Saidi Aya , Samantaray Manoja K. , Abou-Hamad Edy , Poater Albert , Ould-Chikh Samy , Guo Xianrong , Guan Erjia , Ma Tao , Gates Bruce C. , Basset Jean-Marie
Published: January 2020

For the first time, we have synthesized and grafted (Zr(CH3)4(THF)2) complex on SiO2–700 and utilized it for the conversion of CO2 to cyclic carbonates.
Disulfiram as a potent metallo-β-lactamase inhibitor with dual functional mechanisms
Authors: Chen Cheng , Yang Ke-Wu , Wu Lin-Yu , Li Jia-Qi , Sun Le-Yun
Published: January 2020

We report a promising NDM-1 inhibitor, disulfiram, which can covalently bind to NDM-1 by forming an S–S bond with the Cys208 residue. Cu(DTC)2 also inactivated NDM-1 through oxidizing the Zn(ii) thiolate site of the enzyme.
Imaging of ovarian cancers using enzyme activatable probes with second near-infrared window emission
Authors: Chen Ji-An , Pan Hongming , Wang Zhijun , Gao Jie , Tan Jiahui , Ouyang Zhirong , Guo Wei , Gu Xianfeng
Published: January 2020

A β-galactosidase (β-Gal) activatable NIR-II fluorescent probe for visualizing ovarian cancers.
Fast and sensitive fluorescent detection of inorganic mercury species and methylmercury using a fluorescent probe based on the displacement reaction of arylboronic acid with the mercury species
Authors: Neupane Lok Nath , Park Joohee , Mehta Pramod Kumar , Oh Eun-Taex , Park Heon Joo , Lee Keun-Hyeung
Published: January 2020

We present a reaction-based fluorescent probe for Hg2+ and methylmercury based on the displacement reaction of arylboronic acid with mercury species.
Cu(i)-Catalyzed asymmetric intramolecular addition of aryl pinacolboronic esters to unactivated ketones: enantioselective synthesis of 2,3-dihydrobenzofuran-3-ol derivatives
Authors: Ni Chunjie , Gao Jihui , Fang Xianjie
Published: January 2020

An (S,S)-QuinoxP*-supported Cu(i) catalyst has been disclosed for highly enantioselective intramolecular addition of aryl pinacolboronic esters to unactivated ketones under mild reaction conditions.
Smart use of “ping-pong” energy transfer to improve the two-photon photodynamic activity of an Ir(iii) complex
Authors: Jin Zhihui , Qi Shuang , Guo Xusheng , Tian Na , Hou Yuanjun , Li Chao , Wang Xuesong , Zhou Qianxiong
Published: January 2020

A two-photon excited “Ping-Pong” type energy transfer process is for the first time disclosed for enhancing two-photon PDT.
Electrochemical dehydrogenative cross-coupling of two anilines: facile synthesis of unsymmetrical biaryls
Authors: Luo Mu-Jia , Li Yang , Ouyang Xuan-Hui , Li Jin-Heng , He De-Liang
Published: January 2020

New ortho/para-selective dehydrogenative cross-coupling of aryl amines for producing biaryls and incorporating pharmacophores is depicted.
Microwave assisted slurry conversion crystallization for manufacturing of new co-crystals of sulfamethazine and sulfamerazine
Authors: Ahuja Dipali , Ramisetty Kiran A. , Sumanth Peraka Krishna , Crowley Clare M. , Lusi Matteo , Rasmuson Åke C.
Published: January 2020

Formation of co-crystals is faster using microwaves than simple conductive/convective heating to the same temperature.
High efficiency spin filtering in magnetic phosphorene
Authors: Kumari P. , Majumder S. , Rani S. , Nair A. K. , Kumari K. , Kamalakar M. Venkata , Ray S. J.
Published: January 2020

We present high efficiency spin filtering behaviour in magnetically rendered phosphorene, doped with various 3d block elements. A phase diagram was obtained depicting the presence of various electronic and magnetic states.
Elucidating the multi-configurational character of the firefly dioxetanone anion and its prototypes in the biradical region using full valence active spaces
Authors: Ma Yingjin
Published: January 2020

We analyzed the near-degenerate states of the firefly dioxetanone anion (FDO−) and its prototypes, especially in the biradical region, using multi-configurational approaches.
Covalent organic frameworks for separation applications
Authors: Wang Zhifang , Zhang Sainan , Chen Yao , Zhang Zhenjie , Ma Shengqian
Published: January 2020

This review article comprehensively summarizes the recent progress in the development of covalent organic framework materials for separation applications.
Ga/ZSM-5 catalyst improves hydrocarbon yields and increases alkene selectivity during catalytic fast pyrolysis of biomass with co-fed hydrogen
Authors: Iisa Kristiina , Kim Yeonjoon , Orton Kellene A. , Robichaud David J. , Katahira Rui , Watson Michael J. , Wegener Evan C. , Nimlos Mark R. , Schaidle Joshua A. , Mukarakate Calvin , Kim Seonah
Published: January 2020

An integrated experimental and computational study to understand the catalytic upgrading of biomass vapors into high yield of alkenes.
Visible-light-initiated regioselective sulfonylation/cyclization of 1,6-enynes under photocatalyst- and additive-free conditions
Authors: Meng Xiao-Xiao , Kang Qing-Qing , Zhang Jun-Yao , Li Qiang , Wei Wen-Ting , He Wei-Min
Published: January 2020

Without employing a photocatalyst or additive, a strategy has been developed for the visible-light-initiated regioselective sulfonylation/cyclization of 1,6-enynes in 2-methylTHF from sulfonyl chlorides under open-air conditions at room temperature.
Enzymatic-based cytometry, a sensitive single-cell cytometric method to assess BCR-ABL1 activity in CML
Authors: Yu Jinzhu , Oh Ki , Moorthi Sitapriya , Li Ling , Strey Helmut H. , Schuster Michael , Luberto Chiara , Quan Phenix-Lan , Brouzes Eric
Published: January 2020

We developed a simple, rapid and cost-effective enzymatic-based cytometry platform to measure intracellular signaling pathway activity. This platform may be broadly applied in single or dual parameter assays to study cell population heterogeneity.
Highly ordered mesoporous flower-like NiO nanoparticles: synthesis, characterization and photocatalytic performance
Authors: Abboud Mohamed , Abu Haija Mohammad , Bel-Hadj-Tahar Radhouane , Mubarak Ahmed T. , Ismail Issam , Hamdy Mohamed S.
Published: January 2020

Nanostructured flower-like NiO microspheres with flower size ∼2–5 μm and nanoflake size ∼10–100 nm have been successfully synthesized with and without CTAB, and fully characterized, and their photocatalytic performance has been investigated.
A bis(thiosemicarbazonato)-copper complex, a new catalyst for electro- and photo-reduction of CO2 to methanol
Authors: Jiang Wen-Xing , Liu Wei-Xia , Wang Chun-Li , Zhan Shu-Zhong , Wu Song-Ping
Published: January 2020

A bis(thiosemicarbazonato)-copper complex, a new catalyst for electro- and photo-reduction of CO2 to methanol.
Dietary natural products as epigenetic modifiers in aging-associated inflammation and disease
Authors: Evans Levi W. , Stratton Matthew S. , Ferguson Bradley S.
Published: January 2020

Chronic, low-grade inflammation is linked to aging and has been termed “inflammaging”.
Anisotropic protein diffusion on nanosurface
Authors: Liu Yang , Song Xiaohan , Yang Yanmei , Li Yong-Qiang , Zhao Mingwen , Mu Yuguang , Li Weifeng
Published: January 2020

The migration of protein is regulated by the puckered surface of α-PC, resulting in quick and highly directional diffusion. In combination with the bio-compatibility, α-PC is expected to be a novel functional drug delivery agent in biomedical research.
Facile in situ fabrication of biomorphic Co2P-Co3O4/rGO/C as an efficient electrocatalyst for the oxygen reduction reaction
Authors: Guo Xingmei , Qian Cheng , Wan Xiaohan , Zhang Wei , Zhu Haowei , Zhang Junhao , Yang Hongxun , Lin Shengling , Kong Qinghong , Fan Tongxiang
Published: January 2020

Biomorphic Co2P-Co3O4/rGO/C, consisting of Co2P-Co3O4 heterogeneous particles and rGO sheets on a C substrate, is in situ fabricated using G+ bacteria as both a P source and template, which leads to good electrocatalytic performances for the ORR.
Metabolomics-driven identification of perturbations in amino acid and sphingolipid metabolism as therapeutic targets in a rat model of anorexia nervosa disease using chemometric analysis and a multivariate analysis platform
Authors: Yao Hong , Yu Peng-Cheng , Jiang Chun-Ming
Published: January 2020

It is important to explore novel therapeutic targets and develop an effective strategy for the treatment of anorexia nervosa.
Different agglomeration properties of PC61BM and PC71BM in photovoltaic inks – a spin-echo SANS study
Authors: Bernardo Gabriel , Melle-Franco Manuel , Washington Adam L. , Dalgliesh Robert M. , Li Fankang , Mendes Adélio , Parnell Steven R.
Published: January 2020

Fullerene derivatives are used in a wide range of applications including as electron acceptors in solution-processable organic photovoltaics.
Solidification of electroplating sludge with alkali-activated fly ash to prepare a non-burnt brick and its risk assessment
Authors: Xia Ming , Muhammad Faheem , Li Shan , Lin Huirong , Huang Xiao , Jiao Binquan , Li Dongwei
Published: January 2020

Electroplating sludge was solidified in alkali activated fly ash to prepare non-burnt bricks, and their risk to humans was assessed.
Lamellae-controlled electrical properties of polyethylene – morphology, oxidation and effects of antioxidant on the DC conductivity
Authors: Karlsson Mattias E. , Xu Xiangdong , Hillborg Henrik , Ström Valter , Hedenqvist Mikael S. , Nilsson Fritjof , Olsson Richard T.
Published: January 2020

The conductivity of polyethylene consisting of banded spherulites or random lamellae (of same crystallinity) was determined, and the effect of oxidation and antioxidants is described. FEM was used to validate the results experimentally established.
Rational design direct Z-scheme BiOBr/g-C3N4 heterojunction with enhanced visible photocatalytic activity for organic pollutants elimination
Authors: Li Hongfei , Ma Aiqiong , Zhang Dian , Gao Yunqin , Dong Yonghao
Published: January 2020

The morphology, electrochemical property, photoabsorption ability and photocatalytic activity of BiOBr/g-C3N4 composites are discussed. A rational photocatalytic mechanism is proposed.
The effects of geochemical processes on groundwater chemistry and the health risks associated with fluoride intake in a semi-arid region of South India
Authors: Karunanidhi D. , Aravinthasamy P. , Deepali M. , Subramani T. , Roy Priyadarsi D.
Published: January 2020

This study attempts to establish the effects of subsurface geochemical processes based on the hydrogeochemical attributes of 61 well samples collected in a semi-arid region of South India.
Cross-dehydrogenative coupling enables enantioselective access to CF3-substituted all-carbon quaternary stereocenters
Authors: Pan Xiaoguang , Wang Zehua , Kan Linglong , Mao Ying , Zhu Yasheng , Liu Lei
Published: January 2020

A cross-dehydrogenative coupling (CDC) strategy for enantioselective access to acyclic CF3-substituted all-carbon quaternary stereocenters has been established.
Unravelling the selective growth mechanism of AlOx with dimethylaluminum isopropoxide as a precursor in atomic layer deposition: a combined theoretical and experimental study
Authors: Yang Jiaqiang , Cao Kun , Hu Quan , Wen Yanwei , Liu Xiao , Chen Rong , Shan Bin
Published: January 2020

The selective encapsulation of Pt nano catalysts is achieved to maintain the durability and reactivity.
Bifunctional polymer-of-intrinsic-microporosity membrane for flexible Li/Na–H2O2 batteries with hybrid electrolytes
Authors: Zhao Yunfeng , Ma Xiaorong , Li Pengli , Lv Yang , Huang Jianfeng , Zhang Haixia , Shen Yongli , Deng Qibo , Liu Xizheng , Ding Yi , Han Yu
Published: January 2020

Bifunctional polymer-of-intrinsic-microporosity membrane with high ionic conductivity and solvent molecule blocking capability are fabricated and used as separators for flexible Li/Na–H2O2 batteries with hybrid electrolytes.
The affinity of RSK for cylitol analogues of SL0101 is critically dependent on the B-ring C-4′-hydroxy
Authors: Li Yu , Seber Pedro , Wright Eric B. , Yasmin Sharia , Lannigan Deborah A. , O'Doherty George A.
Published: January 2020

The de novo asymmetric synthesis of carbohydrates for the SAR-study of the anticancer natural product, SL0101.
A pre-synthetic strategy to construct single ion conductive covalent organic frameworks
Authors: Li Juan , Zhang Fu-Qiang , Li Falian , Wu Zhenzhen , Ma Canliang , Xu Qinchao , Wang Pengfei , Zhang Xian-Ming
Published: January 2020

A pre-synthetic strategy was proposed to prepare single-ion conductive COFs by using 2,5-diaminobenzene sulfonate salts as the monomers. This strategy is advanced in terms of atom economy and easy to operate in structure detection and preparation.
Fluorescence upconversion by triplet–triplet annihilation in all-organic poly(methacrylate)-terpolymers
Authors: Sittig Maria , Schmidt Benny , Görls Helmar , Bocklitz Thomas , Wächtler Maria , Zechel Stefan , Hager Martin D. , Dietzek Benjamin
Published: January 2020

Fluorescence upconversion by triplet–triplet annihilation is demonstrated for a fully polymer-integrated material, i.e. in the limit of restricted diffusion.
Near-infrared luminescence and magnetic properties of dinuclear rare earth complexes modulated by β-diketone co-ligands
Authors: Li Ling , Gou Jian , Wu Dong-Fang , Wang Yun-Juan , Duan Yao-Yao , Chen Huan-Huan , Gao Hong-Ling , Cui Jian-Zhong
Published: January 2020

The magnetic properties of complexes based on a Schiff base ligand H2L can be modulated by subtle changes in the coordination environment resulting from changes in the co-ligand substituents.
Teaching and Mentoring Students in the Life Participation Approach to Aphasia Service Delivery Perspective
Authors: Hoepner Jerry K. , Sather Tom W.
Published: January 2020

Purpose

This review article examines potential approaches for teaching and mentoring students in the Life Participation Approach to Aphasia (LPAA). The authors review applications of a variety of evidence-based pedagogies, including both course-based and non–course-based teaching interventions. The intent is to create a cohesive and comprehensive resource for teaching and mentoring in the LPAA framework.

Conclusion

Multiple pedagogical strategies are available to support LPAA inside and outside of the classroom. A model for the LPAA teaching and learning framework is introduced, which identifies crucial elements of a comprehensive teaching and mentoring approach. Experiential learning, development of learner knowledge and service delivery perspectives, exposure to the lived experience, and authentic, relationship-based learning are emphasized. A multipronged approach is necessary to develop commitment to an LPAA framework.
Empty substrate‐integrated waveguide phase inverter in millimetre‐wave band application
Authors: Peng Hao , Zhao Faju , Tatu Serioja Ovidiu , Dong Jun , Yang Tao
Published: January 2020

In this Letter, a novel empty substrate‐integrated waveguide (ESIW) phase inverter (PI) applied in millimetre‐wave has been proposed. ESIW PI, based on the structural symmetry design, is made of four parts: top cover, middle layer, ESIW PCB, and bottom layer. Owing to the reversed‐phase transmission channel, the phase difference between the two outputs is absolutely equal to 180°. The simulation and measurement results are in a good agreement. In the entire Ka band, the return losses, insertion losses and amplitude imbalance of ESIW PI are better than 12.7, 2.66, and 0.64 dB ± 0.6 dB, respectively. Besides, the phase difference is within 180.5° ± 2.9° in the same frequency band. In addition, the input and output ports are located in the identical circuit plane, which is easy to integrate with other devices and components.
GMPPT by using PSO based on Lévy flight for photovoltaic system under partial shading conditions
Authors: Motamarri Rambabu , Nagu Bhookya
Published: January 2020

The photovoltaic (PV) system contemplated in the study displays multiple peaks on power–voltage (P–V) curve under partial shading condition (PSC) results in a complicated maximum power point tracking (MPPT) process. Conventional MPPT algorithms work in an effective manner under uniform irradiance conditions. However, these algorithms are unable to track the global peak effectively under different irradiance conditions. In this study, a velocity of particle swarm optimisation‐based Levy flight (VPSO‐LF) for Global MPPT of PV system under PSCs is proposed. For the changes in irradiance, when verified with VPSO‐LF, tracking time and a number of iterations are fewer to reach the global peak of PV array. It also minimises the number of tuning parameters of the velocity of particle swarm optimisation (PSO). The proposed technique is simulated in MATLAB/SIMULINK as well as experimentally validated. It is observed that the results obtained using VPSO‐LF is superior to conventional PSO and hill‐climbing algorithm under different patterns of PV array.
Deep learning enhanced situation awareness for high renewable‐penetrated power systems with multiple data corruptions
Authors: Wang Qi , Bu Siqi
Published: January 2020

High renewable penetration and inevitable data corruptions can prominently jeopardise the security of power systems and greatly challenge the conventional situation awareness (SA). This study proposes an enhanced SA model that solves two major difficulties faced by the conventional SA. The first difficulty is to accurately detect anomalies, especially the imperceptible variation of renewable power output. This is addressed by a novel aggregation of random matrix and long short‐term memory network. The model's high accuracy and alertness in real‐time anomaly detection are achieved by a newly proposed perceptual indicator. The second difficulty is to be robust against multiple data corruptions. In this connection, a dedicated workflow is designed to mitigate the impact of data corruptions from two stages, which ensures the robustness of the enhanced SA model. By comparing with several existing conventional SA models, the proposed enhanced SA model has shown its prominent superiority in several practical scenarios. In addition, a fast security check is also achieved by the enhanced SA model to indicate the security margin of the system on different renewable penetration levels. The enhanced SA model can reinforce the system operators' observability on insecure risks and hedge them against potential data manipulations or cyber attacks.
Enhancement of side‐coupled surface plasmon resonance sensitivity by application of polymethylmethacrylate thin polymer films
Authors: Amjad Saima , Swargiary Kankan , Somarapalli Manjunath , Bora Tanujjal , Hornyak Gabor L. , Mohammed Waleed S.
Published: January 2020

Here the theoretical and experimental investigation for enhancing surface plasmon resonance (SPR) sensitivity in a side‐coupled excitation system by the application of polymethylmethacrylate (PMMA) polymer thin films is presented. Proper selection of film materials, gold layer thicknesses dAu and SPR incident angle (θSPR) resulted in the increased effective refractive index of the sensing region, and hence of the device sensitivity, and the dynamic detection range. This work demonstrates, by first‐order approximations, a characterisation scheme of SPR chips with unknown gold layer thickness dAu and uncertainty in SPR incident angle. The scheme utilised fitting theoretical calculations to measured SPR responses while varying dAu and θSPR in equations. Device sensitivity nearly doubled following application of thin PMMA thin films on gold surfaces when sensing water‐chloroform mixtures as opposed to untreated surfaces that lacked a PMMA layer. The proposed work demonstrates a facilitative balance between theoretical expectations and experimental data to develop sensors for future applications.
Large‐scale data principal component analysis of phase transition from a‐Si:H to nc‐Si:H using PECVD optical emission spectra
Authors: Kau Li‐Han , Huang Hung‐Jui , Chang Hsueh‐Er , Hsieh Yu‐Lin , Fuh Yiin‐Kuen , Li Tomi T.
Published: January 2020

Phase transformation of hydrogenated nanocrystalline silicon (nc‐Si:H) films was essential in the solar cells industry. Therefore, the plasma chemistry monitoring of in‐situ diagnostics optical emission spectroscopy (OES) of plasma‐enhanced chemical vapour deposition (PECVD) is deemed crucial for investigating the phase transformation. The proposed PC2‐OES algorithm can be used to monitor the PECVD process health condition of the crystallisation rate at different hydrogen dilution ratios. Principal component analysis (PCA) was performed to distinguish the crucial role of nc‐Si:H emission characteristics of plasma chemistry and the resultant crystallisation rate. Measurement results revealed that OES spectra characterisation confirmed that the crystallisation rate index (Hα*/SiH*) was highly correlated to hydrogen dilution ratio (R) and phase transformation of nc‐Si:H film. The proposed PCA‐based evaluation method will provide valuable information to reflect consistently the crystallisation rate of deposited films with different hydrogen dilution ratio and possibly other processing parameters of mass flow rate and applied power density.
Un événement sans nom
Authors: Mience Marie
Published: January 2020

La grossesse, lieu de mutations psychique et physique, peut constituer un théâtre traumatique lorsque la dyade mère-enfant se trouve confrontée aux frontières de l’existence. Son interruption précoce et l’effraction du corps peuvent priver la mère de maternalité. L’article interroge la capacité intégrative intime et sociale à partir d’un cas clinique d’hépatopathie gravidique en service de réanimation. Alors que celle intime se confronte aux processus traumatiques, à l’effroi, celle sociale s’entrechoque à l’irreprésentable. Il est question d’un langage dépossédé soumis aux dynamiques du vide, de l’insensé, du mutisme. D’un événement sans nom. La clinique d’un réel qui se heurte aux limites du langage et à la création d’un sens commun.
Optimal ordering policy in a two-echelon supply chain model with variable backorder and demand uncertainty
Authors: Sarkar Sumon , Giri Bibhas Chandra
Published: January 2020

The paper investigates a two-echelon production-delivery supply chain model for products with stochastic demand and backorder-lost sales mixture under trade-credit financing. The manufacturer delivers the retailer’s order quantity in a number of equal-sized shipments. The replenishment lead-time is such that it can be crashed to a minimum duration at an additional cost that can be treated as an investment. Shortages in the retailer’s inventory are allowed to occur and are partially backlogged with a backlogging rate dependent on customer’s waiting time. Moreover, the manufacturer offers the retailer a credit period which is less than the reorder interval. The model is formulated to find the optimal solutions for order quantity, safety factor, lead time, and the number of shipments from the manufacturer to the retailer in light of both distribution-free and known distribution functions. Two solution algorithms are provided to obtain the optimal decisions for the integrated system. The effects of controllable lead time, backorder rate and trade-credit financing on optimal decisions are illustrated through numerical examples.
Vasorelaxing Activity of R-(−)-3′-Hydroxy-2,4,5-trimethoxydalbergiquinol from Dalbergia tonkinensis: Involvement of Smooth Muscle CaV1.2 Channels
Authors: Cuong Nguyen Manh , Son Ninh The , Nhan Ngu Truong , Khanh Pham Ngoc , Huong Tran Thu , Tram Nguyen Thi Thu , Sgaragli Giampietro , Ahmed Amer , Trezza Alfonso , Spiga Ottavia , Fusi Fabio
Published: January 2020

Dalbergia species heartwood, widely used in traditional medicine to treat various cardiovascular diseases, might represent a rich source of vasoactive agents. In Vietnam, Dalbergia tonkinensis is an endemic tree. Therefore, the aim of the present work was to investigate the vascular activity of R-(−)-3′-hydroxy-2,4,5-trimethoxydalbergiquinol isolated from the heartwood of D. tonkinensis and to provide circular dichroism features of its R absolute configuration. The vascular effects of R-(−)-3′-hydroxy-2,4,5-trimethoxydalbergiquinol were assessed on the in vitro mechanical activity of rat aorta rings, under isometric conditions, and on whole-cell Ba2+ currents through CaV1.2 channels (IBa1.2) recorded in single, rat tail main artery myocytes by means of the patch-clamp technique. R-(−)-3′-Hydroxy-2,4,5-trimethoxydalbergiquinol showed concentration-dependent, vasorelaxant activity on both endothelium-deprived and endothelium intact rings precontracted with the α
1 receptor agonist phenylephrine. Neither the NO (nitric oxide) synthase inhibitor Nω-nitro-L-arginine methyl ester nor the cyclooxygenase inhibitor indomethacin affected its spasmolytic activity. R-(−)-3′-Hydroxy-2,4,5-trimethoxydalbergiquinol-induced vasorelaxation was antagonized by (S)-(−)-Bay K 8644 and unaffected by tetraethylammonium plus glibenclamide. In patch-clamp experiments, R-(−)-3′-hydroxy-2,4,5-trimethoxydalbergiquinol inhibited IBa1.2 in a concentration-dependent manner and significantly decreased the time constant of current inactivation. R-(−)-3′-Hydroxy-2,4,5-trimethoxydalbergiquinol likely stabilized the channel in its closed state, as suggested by molecular modelling and docking simulation to the CaV1.2 channel α
1c subunit. In conclusion, D. tonkinensis species may represent a source of agents potentially useful for the development of novel antihypertensive drugs.
Synthesis of Fully Substituted Pyrroles through a Copper-Catalyzed Aza-Michael/Claisen Rearrangement/Cyclization Cascade
Authors: Tan Hao , Jiang Xue-Fei , Jiang Lu , Yuan Chang , Tang Xue , Li Meng-Fan , Liu Si-Wei , Liu Si , Cui Hai-Lei
Published: January 2020

We have developed a copper-catalyzed aza-Michael/Claisen rearrangement/cyclization cascade sequence that affords structurally diverse pentasubstituted pyrroles in acceptable to good yields (31–84%).
Ultrasound-Assisted Synthesis of N-Acylcyanamides and N-Acyl-Substituted Imidazolones from Carboxylic Acids by Using Trichloroisocyanuric Acid/Triphenylphosphine
Authors: Phakhodee Wong , Yamano Dolnapa , Pattarawarapan Mookda
Published: January 2020

A convenient ultrasound-assisted one-pot synthesis of N-acylcyanamides starting from readily available carboxylic acids and sodium cyanamide has been developed. Upon activation in the presence of trichloroisocyanuric acid (TCCA) and triphenylphosphine, a range of carboxylic acids was converted into N-acylcyanamides in good to excellent yields within 10 minutes at room temperature without base. Remarkably, N-acyl-substituted imidazolones were readily accessible through guanylation-cyclization of the in situ generated N-acylcyanamides.
Synthesis of Phosphatidylcholines Possessing Functionalized Acids at sn-2, and 13C–14N and 13C–31P Couplings in Their 13C NMR Spectra
Authors: Morita Masao , Saito Shun , Shinohara Riku , Aoyagi Ryohei , Arita Makoto , Kobayashi Yuichi
Published: January 2020

Although 4-Me2NC5H4N (DMAP) is a standard base for esterification of (2-Me-6-NO2-C6H3CO)2O (MNBA), N-methylimidazole (NMI) was examined for the condensation of acids with 1-stearoyl-lysophosphatidylcholine because of the non-tailing nature of NMI on silica gel. Acids tested were EPA, α-linolenic acid, TBS ethers of 18-HEPE and ricinoleic acid, acid-labile epoxy acids, and a phenyldiynyl acid. The condensation proceeded well with these acids, and chromatographic separation of resulting phosphatidylcholines and remaining NMI was easily performed. During the characterization of the products by 13C NMR spectroscopy, 13C–14N and 13C–31P couplings were observed.
Does Laterality of Lower Extremity Donor Site Affect Outcomes in Microvascular Soft Tissue Lower Extremity Reconstruction?
Authors: Yu Jason W. , Rifkin William J. , Lee Z-Hye , Borab Zachary , Alfonso Allyson R. , Thanik Vishal D. , Levine Jamie P.
Published: January 2020

Background There are many different variables to consider in lower extremity microvascular soft tissue reconstruction including flap choice. Our aim is to objectively evaluate recipient complications related to lower extremity donor flap laterality.

Methods A total of 77 lower extremity soft tissue reconstructions utilizing microvascular free tissue transfers for Gustilo type III between 1979 and 2016 were collected. We compared complication rates between ipsilateral and contralateral donor sites relative to the injured leg. The following parameters were analyzed: overall complications, total flap failure, partial flap failure, major complications, operative takebacks, and salvage rates.

Results In this study, 25 ipsilateral reconstructions were performed, while 52 cases utilized the contralateral leg. Overall complication rates were higher in the ipsilateral group (40.0%) compared with the contralateral side (23.1%) but were not statistically significant (p = 0.12). The ipsilateral group was four times as likely to experience vascular compromise (24.0 vs. 5.8%; p = 0.05). However, there were no significant differences in complications, flap failures or flap survival. Mean operative time was significantly greater in the same side group as compared with the contralateral group (11.3 vs. 7.5 hours; p = 0.006).

Conclusion Although there is a higher risk of anastomotic thrombosis, particularly venous thrombosis, associated with ipsilateral donor-site group, there were no significant differences in complications or flap survival. Flaps can be harvested from a traumatized leg with acceptable complication rates while avoiding the morbidity of operating on an uninjured limb.
Challenges of Setting up a Lower Extremity Reconstruction Practice in a Constrained Environment
Authors: Datli Asli , Karasoy Ismail , Genc Yucel , Pilanci Ozgur
Published: January 2020

Background Microsurgical lower extremity reconstruction remains challenging, especially when resources are limited such as lack of proper equipment, human resources, administrative support, and located in a remote area far from tertiary care. Nevertheless, reconstructive solutions are required, especially when in urgent trauma situations. In this article, we evaluate ways of overcoming challenges and issues that should be considered in a newly established unit by sharing our initial lower extremity reconstruction experience.

Methods We report a local hospital's initial lower extremity reconstruction experience in February 2017 to January 2018. Through a total of seven patients, we tried to enhance the environment, instruments, nurses' contribution, and perspective of the peers and community in terms of factors related to the surgeon, hardware, environment, supporting faculty, reimbursement, and patients.

Results Four patients underwent reconstruction with a freestyle propeller flap and three with an anterolateral thigh flap; in one case, a superficial circumflex iliac artery perforator flap was chosen to salvage partial flap necrosis. Increased experience of the surgeon, new equipment, continuing nurse/patient education, and collaborating with other departments allowed us to choose more challenging flaps and be more meticulous while decreasing the operation time and hospital stay.

Conclusion To start a lower extremity reconstruction practice in a resource-poor environment, the surgeon needs to evaluate the relevant factors; moreover, he or she should continuously improve them until a working methodology is achieved. Despite all the challenges, the adaptations learned at this center can be applied to other local hospitals around the world to set up a lower extremity reconstruction practice and improve its outcomes.
Artificial Intelligence in the Evaluation of Body Composition
Authors: Wang Benjamin , Torriani Martin
Published: January 2020

Body composition entails the measurement of muscle and fat mass in the body and has been shown to impact clinical outcomes in various aspects of human health. As a result, the need is growing for reliable and efficient noninvasive tools to measure body composition. Traditional methods of estimating body composition, anthropomorphic measurements, dual-energy X-ray absorptiometry, and bioelectrical impedance, are limited in their application. Cross-sectional imaging remains the reference standard for body composition analysis and is accomplished through segmentation of computed tomography and magnetic resonance imaging studies. However, manual segmentation of images by an expert reader is labor intensive and time consuming, limiting its implementation in large-scale studies and in routine clinical practice. In this review, novel methods to automate the process of body composition measurement are discussed including the application of artificial intelligence and deep learning to tissue segmentation.
Análise interobservador da classificação das lesões em dedo em martelo segundo Albertoni, utilizando-se radiografias simples: Importância do uso do goniômetro
Authors: Barros Tomás Santos Vasconcelos , Jeha Antônio José , Ribeiro Guilherme Vieira Borchio
Published: January 2020

Objetivos Quantificar o grau de concordância intra- e interobservador da classificação Albertoni e avaliar a importância do uso do goniômetro na diferenciação do grau da lesão.

Métodos Foram selecionados 10 casos de dedo em martelo, os quais foram avaliados por 60 examinadores.

Resultados A concordância interobservador sem o uso do goniômetro foi elevada. Com o uso do goniômetro, obteve-se um “kappa” ainda maior, porém sem relevância estatística.

Conclusão A Classificação de Albertoni possui elevada concordância intra- e interobservador, e o uso do goniômetro se mostrou dispensável para classificar.