bluuebunny/crossref_metadata_2025 huggingface dataset:
Towards mouse genetic-specific RNA-sequencing read mapping
Authors: Gobet Nastassia , Jan Maxime , Franken Paul , Xenarios Ioannis
Published: September 2022

Genetic variations affect behavior and cause disease but understanding how these variants drive complex traits is still an open question. A common approach is to link the genetic variants to intermediate molecular phenotypes such as the transcriptome using RNA-sequencing (RNA-seq). Paradoxically, these variants between the samples are usually ignored at the beginning of RNA-seq analyses of many model organisms. This can skew the transcriptome estimates that are used later for downstream analyses, such as expression quantitative trait locus (eQTL) detection. Here, we assessed the impact of reference-based analysis on the transcriptome and eQTLs in a widely-used mouse genetic population: the BXD panel of recombinant inbred lines. We highlight existing reference bias in the transcriptome data analysis and propose practical solutions which combine available genetic variants, genotypes, and genome reference sequence. The use of custom BXD line references improved downstream analysis compared to classical genome reference. These insights would likely benefit genetic studies with a transcriptomic component and demonstrate that genome references need to be reassessed and improved.
Chromoblastomycosis: A case series from Eastern China
Authors: Liu Sujun , Zhi Huilin , Shen Hong , Lv Wenwen , Sang Bo , Li Qiuping , Zhong Yan , Liu Zehu , Xia Xiujiao
Published: September 2022

Chromoblastomycosis (CBM) is a chronic fungal infection of the cutaneous and subcutaneous tissues caused by brown pigmented fungi. Fonsecaea monophora is one of the most common pathogens of CBM in China. Most formal cases have been reported from Southern China, however, the infection is not uncommon in Eastern China where very few case series are available. To describe the clinical aspects of CBM, we report a series of 11 cases between 2018 and 2021 at a single medical center in Eastern China. The patients were predominately male (n = 9) and the disease duration ranged from 3 months to 20 years. Plaque type lesions were the most common clinical manifestations. There were 7 cases of mild forms and 3 cases of severe forms. Among the 3 severe cases, one case gave up treatment due to economic poverty; one case did not respond to a 1-year systemic treatmen; one case was cured by combination therapy of 10 months. Other cases were cured by treatment with antifungal agents. All cases of direct mycological examination were positive. All isolates were identified by morphology and sequencing of the the ITS regions of ribosomal DNA, Ten were F. monophora and 1 was Cladophialophora carrionii. All cases had been evaluated at other clinics, where 8 cases were misdiagnosed as other diseases. As a neglected tropical disease (NTD), CBM is still a major challenge in the field of dermatology, especially in its severe clinical forms. As an effective and simple diagnostic method of CBM, direct microscopic examination should be further promoted in rural hospitals.
Describing characteristics and treatment patterns of patients hospitalized with COVID-19 by race and ethnicity in a national RWD during the early months of the pandemic
Authors: Vititoe Sarah E. , Easthausen Imaani J. , Lasky Tamar , Chakravarty Aloka , Bradley Marie C. , Roe Laura M. , Gatto Nicolle M. , Weckstein Andrew R. , Garry Elizabeth M.
Published: September 2022

Objective

To describe differences by race and ethnicity in treatment patterns among hospitalized COVID-19 patients in the US from March-August 2020.

Methods

Among patients in de-identified Optum electronic health record data hospitalized with COVID-19 (March-August 2020), we estimated odds ratios of receiving COVID-19 treatments of interest (azithromycin, dexamethasone, hydroxychloroquine, remdesivir, and other steroids) at hospital admission, by race and ethnicity, after adjusting for key covariates of interest.

Results

After adjusting for key covariates, Black/African American patients were less likely to receive dexamethasone (adj. OR [95% CI]: 0.83 [0.71, 0.96]) and more likely to receive other steroids corticosteroids (adj. OR [95% CI]: 2.13 [1.90, 2.39]), relative to White patients. Hispanic/Latino patients were less likely to receive dexamethasone than Not Hispanic/Latino patients (adj. OR [95% CI]: 0.69 [0.58, 0.82]).

Conclusions

Our findings suggest that COVID-19 treatments patients received in Optum varied by race and ethnicity after adjustment for other possible explanatory factors. In the face of rapidly evolving treatment landscapes, policies are needed to ensure equitable access to novel and repurposed therapeutics to avoid disparities in care by race and ethnicity.
Non-communicable diseases prevention in remote areas of Vietnam: Limited roles of health education and community workers
Authors: Le Hang Thi , Le Tuan Anh , Mac Tuan Dang , Nguyen Dua Nhu , Vu Ha Ngoc , Truong Anh Thi Mai , Quang Do Anh Tran , Bui Hoai Thi Thu , Do Huong Thi Thu , Nguyen Anh Thi Hoang , Nguyen Trung Thanh , The Ngo Ngoc , Ngo Tam Thi
Published: September 2022

Objective

This study aimed to measure the exposure of residents to health education messages about non-communicable diseases (NCD)-related risk factors, and activities of village health workers (VHWs) in NCDs prevention and control in the mountainous setting of Vietnam.

Method

A cross-sectional study was performed in Dap Thanh commune (Ba Che, Quang Ninh province, Vietnam), a mountainous area. There were 151 residents aged 18 years or above recruited for this study. Information regarding exposure to messages about risk factors of NCDs, and activities of VHWs was collected via face-to-face interviews using a structured questionnaire. Multivariate logistic regression was employed to identify associated factors with exposing messages about NCD-related risk factors.

Results

The majority of participants heard about messages related to risk factors of NCDs in the last 30 days, from 56.3% (physical inactivity message), 59.6% (diet message), 75.5% (alcohol use message) to 79.5% (smoking message). Radio/television was the most common source of the messages (from 91.8% to 95.8%) and the majority of participants heard these messages from one source (from 77.1% to 80.9%). Most of sample reported the unavailability of VHWs in their locals (53.6%). Among locals having VHWs, health communication and education was the most common service provided (54.3%); however, only 30% received NCD management services. Participants who had other jobs were less likely to hear about diet-related messages (OR = 0.32; 95%CI = 0.11–0.92), and those ever smoking were more likely to hear these messages in the last 30 days (OR = 6.86; 95%CI = 1.06–44.51). People who had diabetes mellitus were more likely to hear physical activity-related messages in the last 30 days (OR = 2.55; 95%CI = 1.20–5.41).

Conclusion

Our findings indicated that health communication regarding risk factors of NCDs in mountainous areas in Vietnam was insufficient, and the role of health workers as formal information source was not recognized. Efforts should be made to increase the capacity and involvement of VHWs in health education and NCD prevention in mountainous regions.
Medium-term impacts of the waves of the COVID-19 epidemic on treatments for non-COVID-19 patients in intensive care units: A retrospective cohort study in Japan
Authors: Watanabe Shusuke , Shin Jung-ho , Okuno Takuya , Morishita Tetsuji , Takada Daisuke , Kunisawa Susumu , Imanaka Yuichi
Published: September 2022

Background

Maintaining critical care for non-Coronavirus-disease-2019 (non-COVID-19) patients is a key pillar of tackling the impact of the COVID-19 pandemic. This study aimed to reveal the medium-term impacts of the COVID-19 epidemic on case volumes and quality of intensive care for critically ill non-COVID-19 patients.

Methods

Administrative data were used to investigate the trends in case volumes of admissions to intensive care units (ICUs) compared with the previous years. Standardized mortality ratios (SMRs) of non-COVID-19 ICU patients were calculated in each wave of the COVID-19 epidemic in Japan.

Results

The ratios of new ICU admissions of non-COVID-19 patients to those in the corresponding months before the epidemic: 21% in May 2020, 8% in August 2020, 9% in February 2021, and 14% in May 2021, approximately concurrent with the peaks in COVID-19 infections. The decrease was greatest for new ICU admissions of non-COVID patients receiving invasive mechanical ventilation (IMV) on the first day of ICU admission: 26%, 15%, 19%, and 19% in the first, second, third, and fourth waves, respectively. No statistically significant change in SMR was observed in any wave of the epidemic; SMRs were 0.990 (95% uncertainty interval (UI), 0.962–1.019), 0.979 (95% UI, 0.953–1.006), 0.996 (95% UI, 0.980–1.013), and 0.989 (95% UI, 0.964–1.014), in the first, second, third, and fourth waves of the epidemic, respectively.

Conclusions

Compared to the previous years, the number of non-COVID-19 ICU patients continuously decreased over the medium term during the COVID-19 epidemic. The decrease in case volumes was larger in non-COVID-19 ICU patients initially receiving IMV than those undergoing other initial treatments. The standardized in-hospital mortality of non-COVID-19 ICU patients did not change in any waves of the epidemic.
Min pig skeletal muscle response to cold stress
Authors: Zhang Dongjie , Ma Shouzheng , Wang Liang , Ma Hong , Wang Wentao , Xia Jiqao , Liu Di
Published: September 2022

The increased sensitivity of pigs to ambient temperature is due to today’s intensive farming. Frequent climate disasters increase the pressure on healthy pig farming. Min pigs are an indigenous pig breed in China with desirable cold resistance characteristics, and hence are ideal for obtaining cold-resistant pig breeds. Therefore, it is important to discover the molecular mechanisms that are activated in response to cold stress in the Min pig. Here, we conducted a transcriptomic analysis of the skeletal muscle of Min pigs under chronic low-temperature acclimation (group A) and acute short cold stress (group B). Cold exposure caused more genes to be upregulated. Totals of 125 and 96 differentially expressed genes (DEGs) were generated from groups A and B. Sixteen common upregulated DEGs were screened; these were concentrated in oxidative stress (SRXN1,MAFF), immune and inflammatory responses (ITPKC,AREG,MMP25,FOSL1), the nervous system (RETREG1,GADD45A,RCAN1), lipid metabolism (LRP11,LIPG,ITGA5,AMPD2), solute transport (SLC19A2,SLC28A1,SLCO4A1), and fertility (HBEGF). There were 102 and 73 genes that were specifically differentially expressed in groups A and B, respectively. The altered mRNAs were enriched in immune, endocrine, and cancer pathways. There were 186 and 91 differentially expressed lncRNAs generated from groups A and B. Analysis of the target genes suggested that they may be involved in regulating the MAPK signaling pathway for resistance to cold. The results of this study provide a comprehensive overview of cold exposure–induced transcriptional patterns in skeletal muscle of the Min pig. These results can guide future molecular studies of cold stress response in pigs for improving cold tolerance as a goal in breeding programs.
Investigation of urinary metabolomics in a phase I hookworm vaccine trial in Gabon
Authors: Betouke Ongwe Madeleine Eunice , Mouwenda Yoanne D. , Stam Koen A. , Kremsner Peter G. , Lell Bertrand , Diemert David , Bethony Jeff , Bottazzi Maria E. , Hotez Peter J. , Leeuwen Remko V. , Grobusch Martin P. , Adegnika Ayola A. , Mayboroda Oleg A. , Yazdanbakhsh Maria
Published: September 2022

Metabolomics provides a powerful tool to study physiological changes in response to various perturbations such as vaccination. We explored whether metabolomic changes could be seen after vaccination in a phase I trial where Gabonese adults living either in rural or semi-urban areas received the subunit hookworm vaccine candidates (Na-GST-1 and Na-APR-1 (M74) adjuvanted with Alhydrogel plus GLA-AF (n = 24) or the hepatitis B vaccine (n = 8) as control. Urine samples were collected and assayed using targeted 1H NMR spectroscopy. At baseline, a set of metabolites significantly distinguished rural from semi-urban individuals. The pre- and post-vaccination comparisons indicated significant changes in few metabolites but only one day after the first vaccination. There was no relationship with immunogenicity. In conclusion, in a small phase 1 trial, urinary metabolomics could distinguish volunteers with different environmental exposures and reflected the safety of the vaccines but did not show a relationship to immunogenicity.
Algorithms for the executable programs planning on supercomputers
Authors: Algashami Abdullah M.
Published: September 2022

This research dealt with the problem of scheduling applied to the supercomputer’s execution. The goal is to develop an appreciated algorithm that schedules a group of several programs characterized by their time consuming very high on different supercomputers searching for an efficient assignment of the total running time. This efficient assignment grantees the fair load distribution of the execution on the supercomputers. The essential goal of this research is to propose several algorithms that can ensure the load balancing of the execution of all programs. In this research, all supercomputers are assumed to have the same hardware characteristics. The main objective is to minimize the gap between the total running time of the supercomputers. This minimization of the gap encompasses the development of novel solutions giving planning of the executable programs. Different algorithms are presented to minimize the gap in running time. The experimental study proves that the developed algorithms are efficient in terms of performance evaluation and running time. A comparison between the presented algorithms is discussed through different classes of instances where in total the number of instances reached 630. The experiments show that the efficient algorithm is the best-programs choice algorithm. Indeed, this algorithm reached the percentage of 72.86%, an average running time of 0.0121, and a gap value of 0.0545.
Egg-adaptive mutations of human influenza H3N2 virus are contingent on natural evolution
Authors: Liang Weiwen , Tan Timothy J. C. , Wang Yiquan , Lv Huibin , Sun Yuanxin , Bruzzone Roberto , Mok Chris K. P. , Wu Nicholas C.
Published: September 2022

Egg-adaptive mutations in influenza hemagglutinin (HA) often emerge during the production of egg-based seasonal influenza vaccines, which contribute to the largest share in the global influenza vaccine market. While some egg-adaptive mutations have minimal impact on the HA antigenicity (e.g. G186V), others can alter it (e.g. L194P). Here, we show that the preference of egg-adaptive mutation in human H3N2 HA is strain-dependent. In particular, Thr160 and Asn190, which are found in many recent H3N2 strains, restrict the emergence of L194P but not G186V. Our results further suggest that natural amino acid variants at other HA residues also play a role in determining the preference of egg-adaptive mutation. Consistently, recent human H3N2 strains from different clades acquire different mutations during egg passaging. Overall, these results demonstrate that natural mutations in human H3N2 HA can influence the preference of egg-adaptation mutation, which has important implications in seed strain selection for egg-based influenza vaccine.
Értelem és érzelem Patrick NessSzólít a szörnyés Seanan McGuireMélybe ránt a Lápvilágkisregényeiben
Authors: Limpár Ildikó
Published: September 2022

Dolgozatomban két olyan ifjúsági fantasyvel foglalkozom, amelynek középpontjában a fiatalkori trauma áll. Kiindulópontom Patrick Ness Szólít a szörny című kisregénye, amelyben a főszereplő fiú édesanyja közelgő halálát egy szörny kéretlen segítségével dolgozza fel. A fa-monstrum történetek segítségével ábrázolja a fiú pszichés tájképét, és ezáltal rombol és gyógyít. Ez a történetmesélés/fantasy stresszoldó szerepéről szóló példabeszéd egyúttal a felnőttvilágba való beavatásról is szól, mivel a fiú megérti azokat a negatív érzelmeit, amelyek egy komplexebb világképet engednek látni. Seanan McGuire kisregényének elemzése a fenti gondolatmenetet viszi tovább. A Mélybe ránt a Lápvilág traumatizált tini (iker) főszereplői egy olyan másik világban találnak ideiglenes otthonra, amely szintén mentális tájképként olvasható: a Lápvilág a gyerekekben lezajló pszichés folyamatok leképződése, és annak monstruozitása a karakterek valós világban érzékelt szükségleteiből adódó válaszként értelmezhető. McGuire különbséget tesz a két ikerleány helyzetértékelési, és helyzetértelmezési képességeit illetően, ennek különbségét is részben a másként megélt traumatizált gyerekkorhoz – és így eltérő érzelmekhez – köti.
The Role of the Business Culture in the Economic Development : Interview with Nikolett Deutsch, Associate Professor, Head of the Institute of Entrepreneurship and Innovation, Corvinus University of Budapest
Authors: Huszák Loretta
Published: September 2022

Loretta Huszák interviewed Nikolett Deutsch, Head of the Institute of Entrepreneurship and Innovation at Corvinus University of Budapest. The interview focused on the role of business culture in economic development, as several international competitions, including the Danube Cup, have proven the importance of soft skills for the success of entrepreneurs. It can be argued that overcoming a country's economic backwardness depends on the development of business culture.
Dynamic Capabilities of Start-Ups
Authors: Farkas Tamás
Published: September 2022

Combining the literature on dynamic capabilities, entrepreneurship, and start-ups, we can come across many new, interesting findings, which are not yet sufficiently explored. The aim of the study is to summarize the dynamic capabilities of start-ups in a literature review. We found that start-ups have fewer, more focused, cheaper dynamic capabilities, which capabilities are based much more on the entrepreneurs' skills. The development of dynamic capabilities takes place with the help of entrepreneurs, and as a result, these are more flexible than the dynamic capabilities of large companies. The implication for future research is that, when examining the dynamic capabilities of start-ups, the entrepreneurs – and their capabilities - should also be examined separately.
Reunited
Authors: Lespinasse Patricia G.
Published: September 2022

This chapter explores the Bebop Era, a particular moment in jazz history bereft of stories pertaining to African American female musicians, in order to provide a counter- narrative that places the black female musician/improviser as central to jazz discourse. This chapter contends that Angelou’s short story becomes a “site” or a repository for the cultural memory of African American women and jazz music. Angelou's “Reunion,” read through a womanist lens, underscores the evolution of the “wild woman” or female jazz musician from object to subject, the nature of cry and response, and highlights the “jazz moment” as a moment of resistance, one that enables African American female musicians to transcend racial and gendered boundaries in order to gain agency and subjectivity through the music.
Introduction
Authors: Karpf Juanita
Published: September 2022

The introduction provides a broad overview of the book’s contents and establishes Hackley as a nationally respected racial uplift activist, acclaimed concert performer and renowned music educator. An energetic and tireless touring race leader and artist, she promoted the use of music as a potent tool in the struggle to ward off the humiliation of racism and segregation. She assembled and advocated an innovative mediatory activist philosophy that bridged the gap between the militant ideals of W.E.B. Du Bois and with those of the more conservative strategies of Booker T. Washington. Her ambitious community programs during the World War years featured the songs and spirituals of black composers and showcased the patriotic zeal and commitment of blacks coast-to-coast. Her agenda included her racially-specific application of tenets associated with the New Thought Movement and she pioneered the introduction of this ecumenical approach to spirituality in black communities.
Formative Years and Early Career
Authors: Karpf Juanita
Published: September 2022

This chapter begins with Hackley’s family fleeing racist violence in Tennessee in 1870 and settling in Detroit. While still in high school, Hackley performed as a soprano soloist and pianist, and gave music lessons to help support her family. Eventually she completed a bachelor’s degree in music at the University of Denver. Upon graduation, she began touring throughout the U.S. as a solo artist. Her repertoire included opera arias, popular ballads, virtuosic showpieces, and spirituals. She also garnered respect as a conductor of community choruses. In 1894, she married Edwin H. Hackley, but the couple separated, permanently, around 1909. During the years 1903-04, she served as the featured vocal instructor at the Washington (DC) Conservatory of Music. By 1910, she had decided to shift her focus away from solo performing. She retired from the concert stage in order to concentrate on racial uplift and teaching.
Music Education and Racial Uplift
Authors: Karpf Juanita
Published: September 2022

Hackley harnessed music education as a means for delivering her mediatory activist agenda. She believed that through music, black Americans could best convince the dominant white population of their considerable talent, ability, determination and accomplishments. She preferred a non-confrontational mode of activism rather than participation in more militant protests. Moreover, by interweaving music teaching with New Thought principles, Hackley encouraged her students and audiences to concentrate on optimism, racial justice and positive change. Music also provided the means for Hackley to reach countless blacks as she offered music lessons and singing instruction to huge audiences at virtually every black community in the continental U.S. Her pedagogical methods relied on components of New Thought. In addition to her activities as a community music educator, she opened a music school for teacher training in Chicago—the Normal Vocal Institute—and was the first black American to establish such a school.
Coda
Authors: Karpf Juanita
Published: September 2022

This chapter provides a summary of major themes and discloses the ways Hackley’s career and historical presence have influenced the world of music and African American history. Hackley mentored many prominent musicians. As her career evolved, she eventually abandoned teaching and performing pieces by whites and instead programmed only spirituals and works by black composers. Her innovative programming of spirituals helped establish these pieces as legitimate selections for the concert stage. Tributes to Hackley include the E. Azalia Hackley Collection of African Americans in the Performing Arts, the Hackley School of Music in New York City, and several choral societies named after Hackley. Although these organizations no longer exist, their one-time significance underscores Hackley’s extraordinary popularity and national influence. This chapter also aligns Hackley’s activism with more recent philosophies and strategies. Her mediatory philosophy and resistance to militancy correspond to recent developments among activists who embrace the tenets of relational activism.
Literary Myths of Matriarchy
Authors: Magoulick Mary J.
Published: September 2022

To understand how the Goddess Myth functions in mainstream cultural contexts today, we examine literary writers’ uses of goddesses and goddess culture. Leslie Marmon Silko’s Gardens in the Dunes (1999) features women characters who are linked by gardening and tinges of goddess cultures. Though the women in the novel all suffer at the hands of Western patriarchal culture (including Native American girls removed from traditional life and an upper-class, educated white woman beaten for her non-traditional, scholarly ways), they nonetheless survive and carve out little spaces for themselves (matrices of matriarchy) where they can be happy. Alice Walker’s Possessing the Secret of Joy (1992) tackles female genital mutilation in Africa, with a main character who suffers greatly then dies as a result of a mythic take-over of former goddess-centered belief that lead to FGM. But the novel ends with other women promising to resist and respect their daughters’ bodies.
Making Mythic Sense
Authors: Magoulick Mary J.
Published: September 2022

This conclusion surveys all the examples analysed (with a detailed table) to show the patterns that many older examples of fantasy fiction by women romanticize goddesses and goddess culture, while film and television examples vilify goddesses and powerful women. More contemporary, intersectional speculative fiction by women moves beyond these dualities to offer the most complex and “hopepunky” versions of The Goddess Myth. The author revisits mythic analysis to show how and why gender binaries still tend to predominate, as well as why this is problematic. Essentializing femininity as overly-emotional (whether the emotions are positive or negative), or as motherly, sexual, or more natural is not good for any complex understanding of gender. The typical work of myth, resolving chaos to make the world appear as a liveable cosmos, is explored in terms of all the examples, showing how deeply (and appropriately) all these new myths reflect our world.
Bulletproof Families
Authors: Meyer Abbye E.
Published: September 2022

“Bulletproof Families” expands this analysis to include narratives in other media: nonfiction essays and memoirs, songs, television series, films, and digital narratives. Twenty-first-century narratives in print and other traditional media generally do little more than illustrate how ill-equipped they are to meet the expectations of digitally based criticism; many transformed-traditional narratives similarly fail to meet cyber-expectations, but occasional texts, such as Speechless, exceed them. Digital narratives allow authors/producers to use various creative techniques, which blur and solidify lines shaping both personal identities and communities. Even though narratives in digital media are plagued by accessibility barriers and stunted by disagreements within and among groups, they exalt the power of young adult disability narratives, when representing family-like unity, to redefine and change cultural norms. These contemporary works, affected by digital media, combine elements of literary criticism, narrative expression, disability theory, and political activism to create and represent the solidarity of family-like communities.
Meet the Brubecks
Authors: Hatschek Keith
Published: September 2022

This first chapter serves as an introduction to Dave Brubeck and his wife, Iola Whitlock Brubeck, who was an equally talented artist and writer. It explores their early years together, their family life, and how they came to be advocates for human rights.
Words and Music
Authors: Hatschek Keith
Published: September 2022

This chapter explains how the original idea came to life, how the Brubecks used real life events to inform the storyline, script, and lyrics that would make up the show. The Real Ambassadors reflects a time in American history when jazz artists wielded tremendous cultural power on the global stage and they used that agency to make the case for equal rights for all individuals regardless of skin color.
Becoming Jazz Ambassadors
Authors: Hatschek Keith
Published: September 2022

On a State Department-sponsored world tour, Dave and Iola Brubeck learned a great deal about foreigners’ perceptions about America’s racial troubles. Traveling behind the Iron Curtain gave them insight into what life was like living under a Communist regime, but also hope that jazz might help reduce tensions and bridge the political divide between the superpowers.
Finding a Producer
Authors: Hatschek Keith
Published: September 2022

To make it to Broadway, the Brubecks would need the support of an established producer. They made the rounds to many of the most successful impresarios of the day but couldn’t line up the necessary funding and support. By now, they had in mind trumpeter and vocalist Louis Armstrong to play the show’s lead character and had to plot out an approach to pitch him on the idea. At the same time, both Brubeck and Armstrong’s mixed race bands were prohibited from playing many concerts due to Jim Crow laws outlawing such performances. This fueled the artists’ desire to bring the story told in The Real Ambassadors to the public.
Standing Up to Segregation
Authors: Hatschek Keith
Published: September 2022

In 1957, Armstrong called out President Eisenhower for not enforcing school integration laws in Little Rock, AL, famously telling the press, “the way they are treating my people in the South, the government can go to hell.” Similarly, Brubeck had to cancel international and domestic concerts in some instances due to the fact that his African American bassist, Eugene Wright, was not allowed to perform with his white band mates. These musicians were on the front lines of the civil rights struggle and the media of the day gave them a platform to air their grievances, adding momentum to their efforts to bring The Real Ambassadors to the stage.
A Night to Remember
Authors: Hatschek Keith
Published: September 2022

When Armstrong and Brubeck met backstage in July 1962 at the Cincinnati Jazz Festival, the two veterans ironed out the area of concern, which was largely the belief that Satchmo would have to perform the musical from memory, which was not the case. The concert performance would be done using music on stands prepared by the Brubecks, similar to the recording sessions which had been so successful. After a full day of rehearsal in a San Francisco hotel ballroom, the cast took the stage at Monterey on Sunday, September 23, 1962 and made jazz history with the cheers of the 6,000 audience members who packed the arena.
Educando en la “cuna de la humanidad”
Authors: García-Arias Vila Guillermo , Ferrandis Lacadena Clara
Published: September 2022

Clara y Guillermo son dos maestros de primaria que hace un año tomaron la decisión de dejar sus puestos de trabajo e irse a Etiopía a igualar en oportunidades a los niños de la tribu Nyangatom y Toposa. Clara ha sido profesora de inglés durante 5 años en el Colegio Santa María La Blanca y los últimos tres años ha realizado las funciones de coordinadora del departamento de bilingüismo. Guillermo cuenta con una experiencia de dos años como profesor de Primaria en el Colegio Monte Tabor y otros tres años como profesor de español en la India. Ambos tienen claro que pese a ser muy lenta y a largo plazo, no hay mejor herramienta que la educación para crear agentes de cambio en una de las sociedades menos desarrolladas, tanto económica como socialmente, de todo el planeta.
Construir una cadena STEM para cultivar el gusto por la ciencia
Authors: Pelayo Blanca , Tortosa de Lucas Carmen , Alvarado Silvia , Gordo Sonia
Published: September 2022

La familia puede convertirse en una gran aliada para fomentar las vocaciones científicas entre los estudiantes. Precisamente, la educación STEM apuesta por crear generaciones de ciudadanos responsables, creativos y competentes para afrontar los desafíos globales. Este artículo aborda los talleres STEM realizados en la Semana de la Ciencia y la Innovación de la Universidad Pontificia Comillas, así como su alcance y su posterior desarrollo con el motivo de las primeras jornadas STEM en la universidad.
La historia interminable
Authors: Martínez Gómez Eduardo , Pereira Domínguez Carmen
Published: September 2022

Bastián Baltasar Bux es un soñador de diez años, huérfano de madre, que sufre la incomprensión paterna y acoso escolar. Un día, de camino a la escuela y huyendo de sus perseguidores, se refugia en la librería de ocasión del Sr. Koreander. Huraño, el propietario se zafa de Bastián, quien aprovecha una distracción para tomarle prestado un misterioso libro: La historia interminable. Escondido en el desván de su escuela, el niño se sumerge en sus páginas, conociendo Fantasía: un imaginativo universo intimidado por la Nada, una nebulosa sin voluntad aparente que lo arrasa todo a su paso. Ante esta amenaza, y dando respuesta a los miedos de los delegados de las regiones que componen su mundo, la Emperatriz infantil encomienda al joven guerrero Atreyu la tarea de salvarlos. Este vivirá un sinfín de aventuras que fascinarán a Bastián, quien no tardará en darse cuenta de que su relación con Atreyu y la obra trasciende una simple lectura, y que la supervivencia de Fantasía pasa también por su responsabilidad.
Nuevos retos en la orientación y acompañamiento educativo a jóvenes con perspectiva de género
Authors: Rodríguez Zapata Nataly , Caraballo Yesenia , Carmona Dania , Sanó Tzzuzy , Bobea Carlos
Published: September 2022

Este artículo aborda elementos relevantes para los procesos de acompañamiento educativo a la juventud con perspectiva de género, a través del análisis reflexivo de los desafíos que enfrentan las y los jóvenes en el contexto actual, desde el enfoque de acompañamiento de Fe y Alegría Dominicana, presentando las acciones realizadas en el proceso de orientación a las juventudes, teniendo en cuenta los diferentes ámbitos de la escuela.
Insect Vector and Seedborne Transmission of Papaya ringspot virus
Authors: Hidayat Sri Hendrastuti , Harmiyati Tutik , Adnan Abdul Muin
Published: September 2022

Penyakit bercak bercincin pada pepaya yang disebabkan oleh Papaya ringspot virus (PRSV) dilaporkan sudah menyebar luas di Indonesia. Pemencaran penyakit ini diketahui terjadi melalui bibit tanaman terinfeksi dan serangga vektor kutudaun.  Penelitian dilakukan untuk menguji efisiensi penularan PRSV melalui dua spesies kutudaun, yaitu Aphis gossypii dan Myzus persicae dan membuktikan bahwa PRSV tidak dapat ditularkan melalui biji. Penularan PRSV isolat Medan melalui kutudaun dilakukan pada tanaman pepaya var. California dengan periode makan akuisisi dan periode makan inokulasi masing-masing selama 10 menit. Minimal 5 ekor A. gossypii dan 10 ekor M. persicae diperlukan untuk keberhasilan penularan PRSV. Penularan PRSV melalui A. gossypii menghasilkan insidensi penyakit yang lebih tinggi dan gejala penyakit yang lebih parah dibandingkan dengan penularan melalui M. persicae. Bibit pepaya dari biji yang berasal dari buah yang menunjukkan gejala bercak bercincin tidak menimbulkan gejala penyakit dan tidak diperoleh fragmen DNA spesifik PRSV pada deteksi PRSV menggunakan metode reverse transcription polymerase chain reaction. Hasil penelitian ini mengonfirmasi potensi kutudaun sebagai vektor PRSV dan membuktikan bahwa PRSV tidak bersifat tular biji.
Suppression of Rigidoporus microporus Inoculum Sources with Soil Solarization and Organic Matter Amendmend
Authors: Widodo Widodo , Fitriani Lisa Bela
Published: September 2022

Cendawan akar putih (Rigidoporus microporus) merupakan salah satu patogen penting yang dapat menyebabkan kerusakan di pertanaman karet. Kemampuan hidup yang tinggi sebagai saprob pada tunggul tanaman dan sisa-sisa akar yang mati menjadikan bagian ini sebagai sumber inokulum penting, baik untuk tanaman karet yang sehat di sebelahnya maupun pada saat melakukan penanaman ulang. Oleh karena itu, pengurangan sumber inokulum ini menjadi kunci penting untuk mencegah penyebaran lebih lanjut. Solarisasi tanah merupakan salah satu metode disinfeksi tanah sebelum tanam dalam pengendalian beberapa hama penyakit tertentu dan dapat mengurangi penggunaan senyawa sintetik di dalam tanah. Penelitian ini bertujuan menentukan solarisasi tanah dan penambahan bahan organik terhadap kelangsungan hidup R. microporus. Solarisasi tanah secara nyata menekan kelangsungan hidup R. microporus pada kedalaman lokasi patogen, yaitu 5 dan 15 cm dari permukaan tanah. Sementara itu perlakuan bahan organik tidak berpengaruh nyata dalam menekan perkembangan R. microporus. Semakin lama waktu solarisasi, kemampuan penekanan terhadap daya hidup inokulum semakin tinggi. Hasil penelitian kami menunjukkan bahwa solarisasi tanah memicu aktivitas bakteri kelompok fluoresens yang diduga dapat menekan inokulum patogen penyebab busuk akar tersebut.
Alasan Mengapa Bezit Dapat Perlindungan Hukum
Authors: Putri Widyani
Published: September 2022

Dalam kuliah hukum benda, kita belajar dua hak kebendaan yakni eigendom atau hak milik dan bezit atau hak menguasai. Sebagai hak menguasai, jelas bezit jauh tingkatnya dibandingkan eigendom. Ia tidak berlaku mutlak dan tidak melindungi penuh pemiliknya. Akan tetapi, apabila pemiliknya memiliki itikad baik, perlindungan hukum terhadapnya adalah keniscayaan. Mengapa demikian? Tulisan ini akan menjawab mengenai mengapa bezit itu ada dan mengapa ia perlu untuk dilindungi sebagai bentuk perlindungan kepada masyarakat. Singkatnya, bezit harus dilindungi oleh hukum karena tidak semua orang berhak menentukan apa yang menjadi hak si A atau si B. Hal ini dimaksudkan agar tidak terjadi kekacauan di masyarakat dan mempertegas bahwa perbuatan main hakim sendiri atau eigenrechting tidak dibernarkan, bahkan pada saat ia memperjuangkan haknya.
Smash that subscribe button! – The evolution of the third-party product reviewer market on YouTube
Authors: Murai Gábor , Kovács Olivér Béla
Published: September 2022

THE AIM OF THE PAPER

In recent years, we could observe a boom in the number of reviewers in the third-party product reviewer market. The structure of this market is an important factor for both firms and consumers as few strong participants could control the narrative around the products. Thus, the main goal of our study is to explore the market structure of this market by shedding light on the drivers behind the growth of the reviewers.

METHODOLOGY

We collected daily data on English language technology product reviewer channels from YouTube API over a 106-day time window to measure how product reviewers grow over time and estimated hierarchical regression to explore the drivers of the growth process.

MOST IMPORTANT RESULTS

We found that (1) big channels grow faster, implying a multiplicative growth process, (2) breakthrough videos boost this process, and (3) the audience’s average revealed valence has a significant connection with the subscriber count increase.

RECOMMENDATIONS

Given the known impact of product reviews on consumers’ decisions, understanding the size and structure of this earned media is key for marketers. Thus, our results and implications are most applicable for firms with products that attract significant demand and supply of product reviews.
Lithuania at the Frontier of the War in Ukraine
Authors: Klumbytė Neringa
Published: September 2022

In the 1990s, Lithuania’s sovereignty politics was defined by its departure from the Soviet authoritarian regime and the transition to democracy, culminating in its integration into the European Union and NATO in 2004. Since Russia’s occupation of Crimea in 2014, Lithuania’s sovereignty has been threatened by Russia’s revisionist politics. Lithuania espoused strong support for Ukraine after Russia’s 2022 invasion, voicing the most radical positions among the European allies accusing Russia of genocide and terrorism. This article discusses the genealogy of sovereignty-building in Lithuania since the collapse of the Soviet Union, illustrating how geopolitical threats shape sovereignty politics, at the center of which is the idea of freedom.
Cyclin D3 restricts SARS‐CoV‐2 envelope incorporation into virions and interferes with viral spread
Authors: Gupta Ravi K , Mlcochova Petra
Published: September 2022

The COVID‐19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) presents a great threat to human health. The interplay between the virus and host plays a crucial role in successful virus replication and transmission. Understanding host–virus interactions are essential for the development of new COVID‐19 treatment strategies. Here, we show that SARS‐CoV‐2 infection triggers redistribution of cyclin D1 and cyclin D3 from the nucleus to the cytoplasm, followed by proteasomal degradation. No changes to other cyclins or cyclin‐dependent kinases were observed. Further, cyclin D depletion was independent of SARS‐CoV‐2‐mediated cell cycle arrest in the early S phase or S/G2/M phase. Cyclin D3 knockdown by small‐interfering RNA specifically enhanced progeny virus titres in supernatants. Finally, cyclin D3 co‐immunoprecipitated with SARS‐CoV‐2 envelope (E) and membrane (M) proteins. We propose that cyclin D3 impairs the efficient incorporation of envelope protein into virions during assembly and is depleted during SARS‐CoV‐2 infection to restore efficient assembly and release of newly produced virions.
Reklamlarda ünlü desteği algısının satın alma niyeti üzerindeki etkisinde marka sadakati ve marka güvenilirliğinin aracılık etkisi
Authors: KARAHAN Mehmet Ozan
Published: September 2022

Araştırmanın amacı, geleneksel olan ve/veya sosyal medya aracılığıyla gerçekleştirilen reklamlarda ünlü desteği algısının satın alma niyeti üzerinde etkisinde marka sadakati ve marka güvenilirliğinin olası aracılık etkilerinin değerlendirilmesidir. Araştırma evrenini Uşak Üniversitesi’nde eğitim ve öğretim hayatını sürdüren ön lisans, lisans ve lisans üstü öğrenciler ve üniversite bünyesinde çalışan akademik ve idari personel oluşturmaktadır. Kolayda örneklem yöntemiyle belirlenen 397 katılımcıdan sağlanan geçerli veri üzerinden yapılan analizler sonucunda, reklamlarda ünlü desteği algısının satın alma niyeti üzerinde doğrudan ve marka sadakati ve marka güvenilirliği aracılığıyla da dolaylı yönden anlamlı etkilerinin olduğu gözlemlenmiştir.
Tersine lojistik uygulamalarının önündeki engellerin ve çözüm önerilerinin çok kriterli karar verme yöntemleriyle değerlendirilmesi
Authors: ÖZGÜNER Zeynep , ÖZGÜNER Mert
Published: September 2022

Artan çevre bilinci, yeşil ürünlere olan talebin artması, sürdürülebilir üretim anlayışının giderek yaygın hale gelmesi gibi gelişmeler işletmeleri yeşil gelişmeleri takip etmek, verimli kaynak kullanımını önemsemek ve üretimden kaynaklanan atıkları en aza indirmek için çeşitli stratejiler geliştirmeye mecbur bırakmıştır.  Tersine lojistik uygulamaları da bu stratejilerin en önemlilerinden birisidir. Fakat, son zamanlarda artan karmaşıklıkla beraber tersine lojistiğin uygulanmasını zorlaştıran ve başarısızlığına neden olan bazı engellerin ortaya çıktığını söylemek mümkündür. Bu noktada işletmeler, tersine lojistik uygulamalarında verimliliği artırabilmek için bu engelleri ortadan kaldıracak stratejiler ve çözüm önerileri geliştirmek zorundadır. Bu çalışmanın amacı, Türkiye imalat endüstrisinde yer alan farklı sektörlerden işletmelerin tersine lojistik uygulamalarında karşılaştıkları engelleri önem düzeylerine göre belirlemek ve bu engelleri ortadan kaldırabilecek çözüm önerilerini değerlendirmektir. Bu maksatla geniş bir literatür araştırması sonucunda belirlenen 12 engel DEMATEL yöntemiyle analiz edilmiştir. Daha sonra bu engelleri ortadan kaldıracak çözüm önerilerini temsil eden 9 çözüm kriteri belirlenmiş ve SWARA yöntemiyle analiz edilmiştir. Elde edilen bulgular en büyük engelin “Yasal sorunlar ve destekleyici politikaların yetersizliği”, en önemli çözüm önerisinin ise “Tersine lojistik uygulamalarının organizasyon vizyon ve misyonuna entegre edilmesi” olduğunu göstermiştir. Görüldüğü üzere tersine lojistik uygulamalarının başarısı noktasında hükümetlerin yasal tedbirlerine olan ihtiyaç açıktır. Ayrıca, işletmelerin kendi içlerinde tersine lojistik uygulamalarını benimsemeleri ve gerekli adımları atmaları önem taşımaktadır.
Revisiting the bank lending channel in Turkey under the unconventional monetary policy framework
Authors: ÖZŞUCA Ekin Ayşe
Published: September 2022

This paper provides empirical evidence regarding the bank lending channel under Turkey's unconventional monetary policy framework. Towards this end, the impact of changes in monetary policy stance on bank credit growth is investigated using a dynamic panel data modelling approach between 2011 and 2019. The empirical results reveal cross-sectional heterogeneity in the loan supply of Turkish banks following a change in monetary policy, which implies an operative bank lending channel in the post-2010 period of the policy mix. Small, liquidity-constrained, and inadequately capitalized banks tend to experience sharper contractions in their lending during monetary policy tightening episodes. Besides, in terms of bank-specific characteristics, the findings demonstrate that larger bank size and capital is associated with a higher loan supply. On the contrary, liquidity is found to harm bank lending.
Malatya Eğitim ve Araştırma Hastanesi’nde sağlık hizmetlerinde tüketici memnuniyetinin ölçülmesi
Authors: ŞAHİN Münevver , GÜLCÜ Yunus
Published: September 2022

Sağlık hizmetleri sunucularının en önemli paydaşlarından olan yataklı tedavi kurumları, hasta memnuniyetini sağlamak için hasta beklentilerinin neler olduğunu, bu konuda nasıl bir yol izleneceğini iyice tahlil etmelidir. Sağlık kuruluşu yönetimi, hasta memnuniyetini sağlamak için hizmet kalitesini ve fiziki koşuları iyileştirmeli, geri dönüşleri dikkate almalıdır. Bu sayede kurumun verimliliği, kâr marjı, kalitesi ve performansı artacaktır. Çalışmanın temel amacı sağlık hizmetlerinde birer tüketici konumunda olan hastaların memnuniyetini etkileyen demografik etmenleri nicel bir yaklaşımla ele almaktır. Araştırmanın verileri, Malatya Eğitim ve Araştırma Hastanesi’nde ayaktan ve yatarak sağlık hizmeti almış basit tesadüfi örnekleme yöntemi ile seçilen 400 kişiden, anket tekniği ile toplanmıştır. Elde edilen veriler istatistiki yöntemlerle analiz edilmiştir. Çalışma sonucunda ölçülen hizmet boyutlarında hasta memnuniyeti ve demografik özellikler arasında anlamlı farklılık olduğu tespit edilmiştir. Bu bağlamda demografik özelliklerin hasta memnuniyetini sağlamada önemli bir bileşen olduğu vurgulanmaktadır.
Örgütsel adaletin örgütsel verimlilik üzerine etkisi: Kamu sektöründe bir çalışma
Authors: DALMIŞ Alper Bahadır
Published: September 2022

Küreselleşen dünyanın rekabetçi piyasa koşullarında örgütler açısından verimliliğin önemi büyüktür. Verimliliğin sağlanabilmesi ve sürdürülebilmesi için örgütlerde çeşitli şartların sağlanabilmesi gerekmektedir. Çalışanların örgütsel adalet algısı da bu şartlardan biridir. Çalışanlar örgütün kendilerine karşı adil olduğunu düşündüklerinde ahlaki bir sorumluluk hissederek daha verimli çalışabilecekleri ve bu durumun örgütsel verimliliği artırabileceği düşünülmektedir. Bu çalışmada örgütsel adaletin verimlilik üzerindeki etkisini incelemek amaçlanmıştır. Bu doğrultuda Ankara ilinde bulunan bir kamu kurumundaki çalışanlar çalışmanın evrenini oluşturmuştur. Araştırmanın örneklemi toplam 278 kişiden (117 kadın ve 161 erkek) oluşmaktadır. Verilerin toplanmasında Demografik Bilgi Formu, Örgütsel Adalet ve Verimlilik Ölçeği kullanılmıştır. Ölçeklerden toplanan verilerin istatistiksel analizinde korelasyon ve regresyon analizi uygulanmıştır. Bulgular çalışanların örgütsel adalet algılarının verimlilik ile ilişkili olduğunu ortaya koymuştur. Ayrıca örgütsel adaletin alt boyutları olan dağıtım adaleti, işlem adaleti ve etkileşimsel adalet boyutlarının da verimlilik ile pozitif ve anlamlı bir ilişkisi olduğu tespit edilmiştir. Çalışanların örgütsel adalet ve alt boyutlarına yönelik algıları arttıkça örgütsel verimliliğin arttığını belirtmek mümkündür. Bu doğrultuda örgütlerde yöneticilerin ve diğer karar vericilerin örgütsel adalet konusunda farkındalık kazanması önerilmektedir.