bluuebunny/crossref_metadata_2025 huggingface dataset:
Odpowiedzialność karna za przestępne współdziałanie w prawie
angielskim po wyroku R v. Jogee; Ruddock v. The Queen
Authors: Brzostek Piotr
Published: January 2019

The combined decisions of the UK Supreme Court and Judicial Committee of the Privy Council in R v. Jogee; Ruddock v. The Queen caused upheaval in the English law on criminal complicity.
The Supreme Court/Privy Council decided that the law on criminal complicity „took a wrong turn” 33 years ago in the Privy Council ruling in Chan Wing-Siu which concerned a controversial doctrine of parasitic joint enterprise liability. According to the said doctrine, if A and B set out to commit a crime X (e.g. robbery) and B foresees that A might commit crime Y (e.g. murder) in the course of committing crime X, B will be liable for crime Y, even if he does not intend that crime Y be committed. The mere fact of foresight on B’s part is enough for him to be criminally liable.
Decision in Jogee; Ruddock is of seminal importance as it overturned the doctrine of parasitic joint enterprise liability. It is doubtful, however, to what extent the Supreme Court has resolved the problems that have bedeviled this area of law. This article presents in outline the English law on criminal complicity and attempts to assess the changes that were introduced in Jogee; Ruddock. A number of issues still call for further refinement and resolution. It appears, however, that the emphasis the Supreme Court put on intention as a required standard of fault, draws, at least superficially, the continental (Polish and German) and English criminal law closer together in terms of mens rea requirements for secondary liability.
RETALIAÇÃO: ANÁLISE DAS ATITUDES DOS SERVIDORES DE UMA INSTITUIÇÃO DE ENSINO SUPERIOR PÚBLICA
Authors: Grassi Doneide Kaufmann , Battistella Luciana Flores , Pezzini Patrícia Nunes
Published: January 2019

A justiça constitui um instrumento fundamental para a garantia da harmonia nas relações humanas. A falta de justiça, em especial em organizações, pode determinar atitudes que propiciam comportamentos disfuncionais, como a retaliação. O presente artigo objetiva avaliar a atitude retaliatória em uma instituição de ensino superior pública. A pesquisa caracteriza-se por ser de natureza quantitativa e de caráter descritivo. O instrumento utilizado foi a escala MARO – Medidas de Atitudes em Relação à Retaliação Organizacional, a qual é composta por dois constructos: comportamento afetivo e conativo. Por meio de um cenário hipotético-conceitual, os respondentes se posicionaram em relação a um caso descrito. Em termos de percepção do comportamento afetivo, identificou-se uma média que aponta para indignação dos respondentes diante da situação de injustiça descrita; em contrapartida, quanto ao componente conativo, a média foi indicativa de um comportamento de não retaliação à organização.
Indicadores centinela para el plan de Bolonia
Authors: Álvarez Suárez Alberto , González García Julio Antonio , Alonso Álvarez Javier , Arias Pérez Jorge Luis , Martís Flórez Jose Ramiro
Published: January 2019

El objeto de nuestro estudio es analizar la influencia que tienen las nuevas metodologías docentes, sobre la presentación de los estudiantes a las pruebas de evaluación planificadas en los Grados en una Escuela de Ingeniería Universitaria.Se han comparado los resultados de la tasa de expectativa de los antiguos y nuevos títulos; éstos últimos adaptados al Espacio Europeo de Educación Superior (EEES). Desde el punto de vista estadístico, nuestro estudio ratifica que existen diferencias significativas en la mejora de la tasa de expectativa con la adaptación al EEES.Las conclusiones más destacadas del estudio hacen referencia al cambio que se está produciendo en la mentalidad del estudiante, se evidencia una mejora del estudiante en el conocimiento adquirido sobre las asignaturas que repercute en que se pueda presentar a las pruebas de evaluación planteadas, es decir el estudiante de Bolonia asume un grado superior de responsabilidad.

The purpose of our study is to analyze the influence of new teaching methods on students taking assessment tests for their degree at an Engineering School. We compare the expectation rate in former and current degrees adapted to the European Higher Education Area (EHEA). From a statistical point of view, our study confirms that there are significant differences in the improvement of the expectation rate following the adaptation to the EHEA. The most relevant conclusions of the study refer to the changes that are occurring in the mentality of students when studying for their degree. There is an improvement in the knowledge gained by students in course subjects, which has an influence on whether they decide to actually take assessment tests. That is to say, Bologna students take on a higher level of responsibility.
Los enfoques de aprendizaje en estudiantes universitarios catalanes mediante el approaches and study skills inventory for students (ASSIST)
Authors: Tesouro Cid Montserrat , Cañabate Ortíz Dolors , Puiggalí Allepuz Juan
Published: January 2019

Este trabajotiene como objetivos la creación y validación de una traducción al catalán delcuestionario Approaches and Study Skills Inventory for Students (ASSIST),analizar cuáles son los estilos de aprendizaje adoptados por los estudiantesuniversitarios y la influencia del género y de la modalidad de estudios. Se aplicó el instrumento a 834 estudiantes de la Universidad de Girona. De losresultados obtenidos se desprende que el alumnado encuestado presenta mayoritariamenteun enfoque profundo si bien en el análisis diferencial por género se observaque las mujeres optaron más por un enfoque estratégico mientras que en loshombres predomina el enfoque profundo. Respecto a si la modalidad de estudioinfluye en los estilos de aprendizaje, se observa que los alumnos de Ciencias yTecnología presentan una prevalencia en el enfoque profundo mientras que los deHumanidades y Educación presentan un enfoque más estratégico.

The aim of this study is to measure the psychometric properties of a Catalan translation of the Approaches and Study Skills Inventory for Students (ASSIST), and to analyse the different learning styles used by university students, considering the influence of gender and type of studies. The instrument was administered to 834 students at the University of Girona. The results showed that most students interviewed had a deep approach to learning, although the analysis by gender showed that females tended to use a more strategic approach, while males used a deep approach predominantly. As to whether the type of studies influenced learning styles, a prevalence of deep approach was found among Science and Technology students, while a more strategic approach was found among Humanities and Education students.
Factores asociados a la brecha regional del rendimiento español en la evaluación PISA
Authors: Gil Flores Javier
Published: January 2019

Estudiamos las diferencias de rendimiento entre las comunidades españolas que ampliaron muestra en la evaluación PISA 2012, identificando dos bloques de comunidades con altas y bajas puntuaciones en el conjunto de competencias evaluadas. Ambos bloques se corresponden geográficamente con territorios del norte y sur del país. Partiendo de un conjunto de indicadores regionales de tipo socioeconómico y educativo que correlacionan con el rendimiento, caracterizamos las comunidades de cada bloque a partir de las diferencias de medias en cada indicador y valoramos su significación a través de métodos bootstrap. Los resultados muestran que, en relación a la brecha regional de rendimiento, los factores exógenos de carácter socioeconómico y cultural juegan un papel más relevante que los recursos destinados a la educación o las características del sistema educativo autonómico consideradas en nuestro análisis.

The present study compares the differences in achievement level between the autonomous communities of Spain that extended their sample in the PISA assessment. Two groups of communities were identified within the national territory, one with high scores and another one with low scores on the assessed competencies. Both groups correspond geographically to autonomous communities in the north and the south of Spain, respectively. By using a range of regional indicators of achievement such as socio-economic and educational indicators, the study attempts to characterize the autonomous communities within each group by analyzing mean differences for each indicator. These differences are then evaluated using bootstrap techniques. The results show that in relation to the achievement gap between regions, exogenous socio-economic and cultural factors play a more important role than educational resources or the characteristics of the regional educational system considered in our analysis.
Rendimiento académico de adolescentes declarados en situación de riesgo
Authors: Rodríguez Rodríguez Daniel , Guzmán Rosquete Remedios
Published: January 2019

La reciente regulación legal y social de la infancia y la adolescencia en situación de riesgo en España hace que sea necesario la generación de un cuerpo de investigación que desde el ámbito de la educación fomente factores protectores y favorezca el bienestar de los menores, ya que a pesar de la heterogeneidad que caracteriza a esta población, el fomento de su éxito educativo será sin duda la mejor medida preventiva de la situación de riesgo. La muestra fue de 232 estudiantes declarados en situación de riesgo, con bajo (115 estudiantes) y buen rendimiento académico (117 estudiantes) escolarizados en Educación Secundaria, de los que se recogió información sobre variables personales y sociofamiliares que guardan relación con el rendimiento. En relación a las variables personales, los resultados mostraron que los alumnos que tienen un buen rendimiento académico se caracterizan por tener mayores puntuaciones en sus metas académicas, atribuyen su éxito académico a su propia capacidad y esfuerzo y perciben un mayor apoyo familiar afectivo de su familia. Respecto a las variables familiares, se encontró que los alumnos que tienen un buen rendimiento se caracterizan por tener un mayor porcentaje de padres con titulación universitaria, padres y madres que trabajan como funcionarios y madres que esperan que su hijo o hija alcance una titulación universitaria. Como conclusión se confirma la importancia del trabajo conjunto desde los ámbitos educativo y social para prevenir el fracaso escolar.

The recent legal and social regulation of childhood and adolescence at risk in Spain makes it necessary to create a body of research that encourages, from the field of education, protective factors and promotes the wellbeing of children, because despite of the heterogeneity that characterizes this population, the promotion of educational success will undoubtedly be the best preventive measure of the risk situation. The sample was of 232 students declared at risk, with students of low (115) and good academic achievement (117) enrolled in Secondary Education, of which we collected information about personal and family variables that are related to achievement. Regarding the personal variables, results showed that students that have a good academic achievement are characterized by higher scores in their academic goals, they attribute their academic success to their own capacity and effort and they perceive a greater affective family support from their family. Regarding family variables, we found that students with good academic achievement have a higher percentage of parents with a university degree, parents who work in the public sector and mothers who expect that their son or daughterwill achieve a university degree. In conclusion, the importance of working together from the educational and social levels to prevent school failure is confirmed.
Componentes y dimensiones que caracterizan una buena praxis en Educación Infantil (0-3 años)
Authors: Mendioroz Lacambra Ana María , Rivero Gracia Pilar
Published: January 2019

Para mejorar la calidad educativa, es fundamental investigar y visibilizar buenas prácticas docentes. Desde hace varios años y en esta línea, las autoras intervienen en proyectos de innovación e investigación centrados en la Educación Infantil, lo que les ha permitido conocer y analizar la realidad educativa de esta etapa. Este artículo se centra en los resultados de un proyecto concreto de investigación, en el que participan universidades de ámbito europeo y latinoamericano con el objetivo de reconocer, analizar, normalizar, representar y hacer visibles 100 buenas prácticas en Educación Infantil, en un marco plural de características y condiciones. Se emplea una metodología cualitativa que permite vincular creencias implícitas con las prácticas docentes, y se recopilan los datos mediante entrevistas, observaciones en el aula y registros. En esta ocasión se presentan los criterios registrados por el grupo de investigación para reconocer buenas prácticas en el tramo 0-3 años, donde se evidencian, mediante las narrativas de las docentes, apoyadas por las observaciones y registros realizados en el aula, los componentes conceptuales y operacionales que caracterizan una buena praxis en Educación Infantil, en la línea de estudios precedentes.

To improve the educational quality, it is fundamental to investigate and make visible good teaching practices. For several years and in this line, the authors have intervened in innovation and research projects focused on early childhood education, which has allowed them to know and analyze the educational reality of this stage. Specifically this work that is now presented, is the result of a subsequent research project, in which European universities and Latin American universities participate, with the aim of detecting, analyzing, systematizing and representing 100 good practices in Early Childhood Education, in a framework of plural characteristics and conditions. A qualitative methodology is used to link assumed beliefs with teaching practices, and data are collected through interviews, observations in the classroom and records. This article presents some of the criteria proposed by the research group to identify good practices, in the 0-3year period, where they are evidenced, through the narratives of the teachers, supported by the observations and records made in the classroom, the conceptual and operative components that characterize a good praxis in Infantile Education.
La percepción del profesorado de Educación Primaria y Educación Secundaria sobre las variables que influyen en el Abandono Escolar Temprano
Authors: GONZALEZ RODRIGUEZ DIEGO , VIEIRA ALLER MARIA JOSE , VIDAL GARCIA JAVIER
Published: January 2019

El Abandono Escolar Temprano es un problema que preocupa a los países de todo el mundo. Esto se debe a que afecta directamente tanto a la vida de los estudiantes que abandonan como a la sociedad en general. El objetivo del presente estudio es conocer la percepción que tienen los docentes de las etapas de Educación Primaria, Educación Secundaria Obligatoria y Bachillerato sobre las variables más influyentes en el Abandono Escolar Temprano. La investigación llevada a cabo sigue una metodología de encuesta, mediante la administración de un cuestionario con 85 variables identificadas en la literatura científica. Se obtuvieron 134 respuestas de docentes de toda España. Los resultados indican que las variables consideradas más relacionadas con el Abandono Escolar Temprano son las vinculadas a características individuales y familiares. En menor medida, se consideran relacionadas la actividad escolar del individuo como estudiante, la actitud del profesorado, el comportamiento de los compañeros de clase y las características del centro. Se concluye que estamos ante un fenómeno de causas complejas que no debe ser abordado exclusivamente desde una perspectiva académica sino multidisciplinar.

Early School Leaving is a problem that worries countries around the world. This is because it directly affects both the lives of students who abandon and society in general. The objective of the present study is to know the perception that Primary Education, Compulsory Secondary Education and Upper Secondary Education teachers have on the most influential variables that affect Early School Leaving. The research carried out follows a survey methodology, by administering a questionnaire with 85 variables identified in the scientific literature. 134 responses were obtained from teachers throughout Spain. The results indicate that the variables considered more related to Early School Leaving are those related to individual and family characteristics. To a lesser extent, the school activity of the individual as a student, the attitude of the faculty, the behaviour of the classmates and the characteristics of the school are considered related. We conclude that we are facing a phenomenon of complex causes that should not be approached exclusively from an academic perspective but multidisciplinary.
Le trésor de la langue de René Lussier : documentation d’un voyage, de la quête linguistique au débat politique
Authors: Dall’Ara-Majek Ana
Published: January 2019

Chef-d’oeuvre du compositeur et musicien René Lussier, Le trésor de la langue s’articule autour de trois axes : l’approche musicale et linguistique fait état de la particularité de l’oeuvre à transcrire instrumentalement la voix parlée tout en la réorchestrant dans des styles musicaux variés ; l’approche documentaire se focalise sur le récit du voyage du compositeur entre Montréal et Québec, et offre un témoignage de l’oeuvre en train de se faire ; enfin l’approche historique fait le lien entre la documentation collectée et agencée par le compositeur, et les enjeux historiques et politiques qui s’en dégagent, remettant sur le devant de la scène les événements marquants du xxe siècle, notamment le débat sur la souveraineté et l’épineuse question identitaire au Québec.
Dis-moi ta vision de la spiritualité et je te montrerai l’univers de ta danse
Authors: Pouliot Étienne
Published: January 2019

Trois déplacements majeurs dans la conception de la spiritualité sont présentés en vue de fournir à cet égard des repères épistémiques et historiques, relativement à la tradition philosophique occidentale et de la tradition spirituelle chrétienne. Les renversements de perspective qui s’y sont opérés définissent de façon liminaire une orientation tantôt objective, tantôt subjective, tantôt langagière (rapport sujet-objet lui-même) de la spiritualité. Des considérations tout aussi liminaires sur le corps et la danse sont proposées en conséquence. Par cette analyse, la spiritualité se voit progressivement accorder la place de principe herméneutique et le rôle de pratique herméneutique, la faisant passer d’un traitement mimétique à une approche sémiotique : d’où les effets sur la question de la danse et du corps.
Los pobres están invitados a la mesa. Debates y proyectos transnacionales de alimentación popular en América del Sur, 1930-1950
Authors: Yáñez Andrade Juan Carlos
Published: January 2019

Objective/context: This article analyzes the debates on feeding the popular classes in South America between 1930 and 1950, offering a comparative framework for the experiences of the people’s restaurants or dining rooms which were established in Argentina, Uruguay, Peru and Chile. Originality: The phenomenon of feeding the poor has traditionally been treated as a strictly national problem, in the framework of the formulation of public policies which strengthened the action of the State. Without denying the value of that standpoint, this article systematizes the debates which arose in continental institutions, under the auspices of supranational bodies like the Pan-American Union and the Pan American Health Organization. Methodology: This article is framed within an analytical and descriptive investigation which systematizes the debates about feeding the popular classes in South America. The school of transnational focuses approaches the phenomenon of feeding as a set of problems where diverse international institutions, professional associations and State agencies regionally discuss policies for social intervention in the matter. This helps us to understand the common and distinguishing features which were found in the policies for feeding the popular classes in the region, discussing in some cases the circulation of ideas or influences which arose when these experiences were shared in international forums. Conclusions: Here, we show the reach which international bodies had in the discussion about formulating State policies for feeding the poor. We analyze the concrete conditions in which such popular restaurants worked in different countries, in accordance with the demands for meeting international standards and the cultural variables characteristic of each nation.
Multiple factors maintain assembled trans-SNARE complexes in the presence of NSF and αSNAP
Authors: Prinslow Eric A , Stepien Karolina P , Pan Yun-Zu , Xu Junjie , Rizo Josep
Published: January 2019

Neurotransmitter release requires formation of trans-SNARE complexes between the synaptic vesicle and plasma membranes, which likely underlies synaptic vesicle priming to a release-ready state. It is unknown whether Munc18-1, Munc13-1, complexin-1 and synaptotagmin-1 are important for priming because they mediate trans-SNARE complex assembly and/or because they prevent trans-SNARE complex disassembly by NSF-αSNAP, which can lead to de-priming. Here we show that trans-SNARE complex formation in the presence of NSF-αSNAP requires both Munc18-1 and Munc13-1, as proposed previously, and is facilitated by synaptotagmin-1. Our data also show that Munc18-1, Munc13-1, complexin-1 and likely synaptotagmin-1 contribute to maintaining assembled trans-SNARE complexes in the presence of NSF-αSNAP. We propose a model whereby Munc18-1 and Munc13-1 are critical not only for mediating vesicle priming but also for precluding de-priming by preventing trans-SNARE complex disassembly; in this model, complexin-1 also impairs de-priming, while synaptotagmin-1 may assist in priming and hinder de-priming.
A conserved filamentous assembly underlies the structure of the meiotic chromosome axis
Authors: West Alan MV , Rosenberg Scott C , Ur Sarah N , Lehmer Madison K , Ye Qiaozhen , Hagemann Götz , Caballero Iracema , Usón Isabel , MacQueen Amy J , Herzog Franz , Corbett Kevin D
Published: January 2019

The meiotic chromosome axis plays key roles in meiotic chromosome organization and recombination, yet the underlying protein components of this structure are highly diverged. Here, we show that ‘axis core proteins’ from budding yeast (Red1), mammals (SYCP2/SYCP3), and plants (ASY3/ASY4) are evolutionarily related and play equivalent roles in chromosome axis assembly. We first identify ‘closure motifs’ in each complex that recruit meiotic HORMADs, the master regulators of meiotic recombination. We next find that axis core proteins form homotetrameric (Red1) or heterotetrameric (SYCP2:SYCP3 and ASY3:ASY4) coiled-coil assemblies that further oligomerize into micron-length filaments. Thus, the meiotic chromosome axis core in fungi, mammals, and plants shares a common molecular architecture, and likely also plays conserved roles in meiotic chromosome axis assembly and recombination control.
Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning
Authors: Urata Shinji , Iida Tadatsune , Yamamoto Masamichi , Mizushima Yu , Fujimoto Chisato , Matsumoto Yu , Yamasoba Tatsuya , Okabe Shigeo
Published: January 2019

The highly organized spatial arrangement of sensory hair cells in the organ of Corti is essential for inner ear function. Here, we report a new analytical pipeline, based on optical clearing of tissue, for the construction of a single-cell resolution map of the organ of Corti. A sorbitol-based optical clearing method enabled imaging of the entire cochlea at subcellular resolution. High-fidelity detection and analysis of all hair cell positions along the entire longitudinal axis of the organ of Corti were performed automatically by machine learning–based pattern recognition. Application of this method to samples from young, adult, and noise-exposed mice extracted essential information regarding cellular pathology, including longitudinal and radial spatial characteristics of cell loss, implying that multiple mechanisms underlie clustered cell loss. Our method of cellular mapping is effective for system-level phenotyping of the organ of Corti under both physiological and pathological conditions.
HDAC3 restrains CD8-lineage genes to maintain a bi-potential state in CD4+CD8+ thymocytes for CD4-lineage commitment
Authors: Philips Rachael Laura , Lee Jeong-Heon , Gaonkar Krutika , Chanana Pritha , Chung Ji Young , Romero Arocha Sinibaldo R , Schwab Aaron , Ordog Tamas , Shapiro Virginia Smith
Published: January 2019

CD4 and CD8 T cells are vital components of the immune system. We found that histone deacetylase 3 (HDAC3) is critical for the development of CD4 T cells, as HDAC3-deficient DP thymocytes generate only CD8SP thymocytes in mice. In the absence of HDAC3, MHC Class II-restricted OT-II thymocytes are redirected to the CD8 cytotoxic lineage, which occurs with accelerated kinetics. Analysis of histone acetylation and RNA-seq reveals that HDAC3-deficient DP thymocytes are biased towards the CD8 lineage prior to positive selection. Commitment to the CD4 or CD8 lineage is determined by whether persistent TCR signaling or cytokine signaling predominates, respectively. Despite elevated IL-21R/γc/STAT5 signaling in HDAC3-deficient DP thymocytes, blocking IL-21R does not restore CD4 lineage commitment. Instead, HDAC3 binds directly to CD8-lineage promoting genes. Thus, HDAC3 is required to restrain CD8-lineage genes in DP thymocytes for the generation of CD4 T cells.
Identification of a bilirubin receptor that may mediate a component of cholestatic itch
Authors: Meixiong James , Vasavda Chirag , Green Dustin , Zheng Qin , Qi Lijun , Kwatra Shawn G , Hamilton James P , Snyder Solomon H , Dong Xinzhong
Published: January 2019

Various pathologic conditions result in jaundice, a yellowing of the skin due to a buildup of bilirubin. Patients with jaundice commonly report experiencing an intense non-histaminergic itch. Despite this association, the pruritogenic capacity of bilirubin itself has not been described, and no bilirubin receptor has been identified. Here, we demonstrate that pathophysiologic levels of bilirubin excite peripheral itch sensory neurons and elicit pruritus through MRGPRs, a family of G-protein coupled receptors expressed in primary sensory neurons. Bilirubin binds and activates two MRGPRs, mouse MRGPRA1 and human MRGPRX4. In two mouse models of pathologic hyperbilirubinemia, we show that genetic deletion of either Mrgpra1 or Blvra, the gene that encodes the bilirubin-producing enzyme biliverdin reductase, attenuates itch. Similarly, plasma isolated from hyperbilirubinemic patients evoked itch in wild-type animals but not Mrgpra1-/- animals. Removing bilirubin decreased the pruritogenic capacity of patient plasma. Based on these data, targeting MRGPRs is a promising strategy for alleviating jaundice-associated itch.
Crisis y Revolución
Authors: Valencia Adrian Sotelo
Published: January 2019

<span style="font-size: 10pt; font-family: Garamond; mso-fareast-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: PT-BR; mso-fareast-language: PT-BR; mso-bidi-language: AR-SA;">O artigo retoma a teoria materialista do desenvolvimento e decadência do capitalismo a partir da teoria do valor originalmente elaborada e exposta por Karl Marx nos Grundrisse e na Crítica da Economia Política, reafirmando que a produção do valor depende exclusivamente da força de trabalho. Conforme acontece na atualidade, o capital desloca a força de trabalho em todas as indústrias, serviços e atividades, assim como em todos os países, territórios e regiões do mundo inteiro; de preferência, os trabalhadores são despedidos e se transferem para atividades especulativas características do capital fictício. Essa menor disposição de força de trabalho termina por castigar severamente a taxa média de lucro e, com o tempo, acaba precipitando a crise. A crise capitalista em curso deriva da insuficiência e, até certo ponto, da incapacidade dos mecanismos do sistema para gerar suficiente produção de valor no processo de trabalho, para valorizar o capital investido (em meios de produção, matérias primas e em força de trabalho ou capital variável); para criar mais valia e restituir o aumento da taxa de lucro. Essas limitações do capital financeiro (capital fictício) provocam o desvio para a esfera especulativa e contribuem na formação de bolhas especulativas nefastas em áreas como as imobiliárias, energéticas e de alimentos. Por mais que continue a aumentar a produtividade, a se desenvolver a revolução tecnológica e a “se poupar a força de trabalho”, a redução do tempo socialmente necessário para a produção de mercadorias e de força de trabalho vai se tornando cada vez mais difícil e marginal. É desse modo que o sistema capitalista entra numa crise orgânica, estrutural e “civilizacional”, tal como acontece na atualidade. Ir além do capital significa construir as estruturas e superestruturas da nova sociedade não capitalista baseada em um novo modo de produzir, de trabalho e de relações sociais humanas harmoniosas e solidárias. Dificilmente gesta-se uma revolução exitosa sem a educação dos seus protagonistas, ou seja, as massas organizadas em frentes, partidos e sindicatos, que permita elevar o nível de consciência social, política e cultural. Para isso é preciso uma breve análise do núcleo da crise do sistema.

 
Capitalismo e Revolução
Authors: Feitas Francisco Máuri de Carvalho
Published: January 2019

<span style="font-size: 10pt; color: black; font-family: Garamond; mso-fareast-font-family: Batang; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: PT-BR; mso-fareast-language: PT-BR; mso-bidi-language: AR-SA;">O presente estudo foi movido pela nova crise cíclica do capitalismo procurando resgatar sua relação histórica com a revolução. O autor ao perquirir sobre a relação entre capitalismo e imperialismo (causa) e seu sucedâneo a revolução (conseqüência histórica), entende não ser possível se ater apenas à visão econômica da historia, eis que não se pode prescindir de uma visão histórica da economia, pois não há nenhuma separação insuperável entre economia e história. No estudo afirma-se a teoria marxista como sendo aquela que melhor explica a evolução das relações econômicas nas sociedades humanas no transcurso de um longo e conflituoso processo histórico. Para Marx <span style="font-size: 10pt; color: black; font-family: Garamond; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: Arial; mso-ansi-language: PT-BR; mso-fareast-language: PT-BR; mso-bidi-language: AR-SA;">a permanência do primado do capital inviabiliza a realização das demandas da classe operária. É a revolução e não a educação o mecanismo utilizado para demolir a ordem jurídica e econômica capitalista. O opúsculo Glosas Críticas ao artigo ‘O rei da Prússia e a reforma social’, é o ponto chave do itinerário intelectual à compreensão da sublevação dos tecelões da Silésia como marco de uma nova fase do pensamento de Marx, ao incorporar definitivamente a revolução socialista como parteira da história. O objetivo deste estudo é contrapor-se à falsificação em curso do marxismo que a todo custo procura impedir o desvelar das sutis mentiras da ideologia neoliberal, para resgatar a obra marxista e seu verdadeiro valor, não como dogma, como dizia Engels, mas como guia para a ação. Nas considerações finais afirmo: 1. O marxismo não pode ser reduzido à simples disciplina universitária por uma simples questão: ele só pode ser reencontrado em sua totalidade a partir do movimento obreiro revolucionário, isto é, em sua estreita relação com a luta de classes, fora da qual perde todo seu significado histórico e filosófico, bem como sua importância política e revolucionária. 2. A<span style="font-size: 10pt; color: black; font-family: Garamond; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: PT-BR; mso-fareast-language: PT-BR; mso-bidi-language: AR-SA;"> revolução é parte indissociável do processo da transformação social, quer dizer, a revolução está posta como questão incontornável para aqueles que acreditam e lutam pela edificação da sociedade comunista. 
Ética e atuação política no marxismo: subsidios para uma discussão contemporânea
Authors: Oliveira Igor Fernandes
Published: January 2019

O presente artigo pretende colaborar para as discussões em torno da relação entre ética e atuação política no interior do marxismo. Para tanto, elegemos discutir o tema a partir dos textos clássicos de Marx e Gramsci. O primeiro formulou suas teses atacando os problemas tradicionais colocados pela relação entre “ética” e “política” em seu próprio tempo. Já Gramsci, colaborou de forma decisiva para reconceitualizar a questão, historicizando-a e associando-a integralmente a um movimento político (hegemônico). Apesar da clara limitação do número de autores discutidos, pode-se argumentar que os problemas e soluções colocadas por Marx e Gramsci atravessam o debate marxista em geral, permitindo, por isso, vislumbrar alguns dilemas e possibilidades centrais dados à problemática no campo.

 

 
Manifesto do Partido Comunista
Authors: Marx Karl Heinrich , Engels Friedrich
Published: January 2019

Manifesto escrito por Karl Marx e Friedrich Engels sob encomenda da Liga dos Comunistas que virá a se constituir no documento político mais importante da era moderna. Escrito em 1848, o documento está completando em 2010 162 anos.
LUCA BASSO, Socialità e isolamento, la singularidade in Marx, Carocci, Roma, 2008, pp. 238.
Authors: Evangelista Roberto
Published: January 2019

Resenha da obra <span style="font-size: 11pt; line-height: 115%; font-family: Garamond; mso-fareast-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: PT-BR; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">Socialità e isolamento, la singularidade in Marx.
O PAPEL DO CURRÍCULO ESCOLAR NO DESENVOLVIMENTO HUMANO: CONTRIBUIÇÕES DA PEDAGOGIA HISTÓRICO-CRÍTICA E DA PSICOLOGIA HISTÓRICO-CULTURAL
Authors: Malanchen Julia , Anjos Ricardo Eleutério dos
Published: January 2019

Este trabalho aponta as articulações existentes entre os fundamentos da psicologia histórico- cultural e da pedagogia histórico-crítica, no que tange à questão dos conteúdos que devem compor o currículo escolar. A correta organização do processo de ensino pelo professor, por meio de conhecimentos científicos, bem como a apropriação do conteúdo clássico, por parte do aluno, favorece o desenvolvimento psíquico ao suscitarem o desenvolvimento das funções psíquicas superiores em suas máximas possibilidades. Desse modo, afirmamos que a psicologia histórico-cultural e a pedagogia histórico-crítica alinham-se tanto no que se refere à perspectiva marxista da revolução socialista, como no que se refere à concepção de formação da individualidade e do papel da educação escolar na emancipação humana. 
A PEDAGOGIA HISTÓRICO-CRÍTICA E O CURRÍCULO BÁSICO PARA A ESCOLA PÚBLICA DO PARANÁ – 1990: DO MITO À REALIDADE
Authors: Baczinski Alexandra Vanessa de Moura
Published: January 2019

Esta entrevista, realizada com Alexandra Vanessa de Moura Baczinski, autora do livro: A Implantação oficial da Pedagogia Histórico-Crítica na rede pública do Estado do Paraná (1983-1994): legitimação, resistências e contradições, resultado de sua pesquisa de mestrado, que foi publicada pela Editora Autores Associados, em 2011, aborda um pouco da trajetória da Pedagogia Histórico-Crítica, analisa as dificuldades acerca de sua implantação, se foi efetivada ou não na Rede Estadual do Paraná, a contribuição que ela tem dado à educação paranaense, discute até que ponto pode se dizer que se trata de uma pedagogia revolucionária e se continua válida e atual enquanto proposta pedagógica na atualidade. 
PEDAGOGIA HISTÓRICO-CRÍTICA: PRIMEIRAS APROXIMAÇÕES
Authors: Balzan Celso Sidinei
Published: January 2019

O livro Pedagogia Histórico-Crítica: primeiras aproximações foi publicado em 1991 pelo professor Dermeval Saviani. Nesta obra, o autor reúne textos escritos durante a década de 1980 (resultantes de conferências, seminários, debates) com o objetivo de oportunizar aos educadores brasileiros uma sistematização inicial de seu pensamento pedagógico, principalmente no que se refere à concepção educacional da pedagogia histórico-crítica. 
DESENVOLVIMENTO NACIONAL E REGIONAL E AS DEMANDAS AO CAMPO DA EDUCAÇÃO
Authors: Ferretti Celso João
Published: January 2019

O objetivo deste texto é o de promover uma reflexão a respeito das relações estabelecidas entre educação e desenvolvimento, principalmente a partir da década de 1990 do século passado. A razão para tal deve-se à impropriedade do caráter mais ou menos direto atribuído a tal relação, fazendo supor que o campo da educação dispõe de condições para influenciar o desenvolvimento econômico social com a ênfase que lhe atribuem a mídia e mesmo certos discursos oficiais. A preocupação com tal temática acentuou-se ainda mais nos anos recentes, tanto pelo papel atribuído aos Institutos Federais de Educação, Ciência e Tecnologia nesse processo, quanto pela constatação de um crescente processo de deslocamento de recursos públicos para agências privadas que atuam no campo educacional e, também, pela investida que vem se verificando, tanto no âmbito público quanto no privado, no sentido de promover mudanças no âmbito do Ensino Médio e da Educação Profissional com vistas às relações impróprias acima referidas. 
A CRISE DO CAPITAL, A CLASSE TRABALHADORA, O PARTIDO DOS TRABALHADORES E OS MOVIMENTOS SOCIAIS E O SOCIALISMO
Authors: Antunes Ricardo , Sampaio Júnior Plínio De Arruda , Santos Ariovaldo Dos
Published: January 2019

Entrevista Ricardo Antunes
TARBP2‐mediated destabilization of Nanog overcomes sorafenib resistance in hepatocellular carcinoma
Authors: Lai Hui‐Huang , Li Chih‐Wei , Hong Chih‐Chen , Sun Hung‐Yu , Chiu Ching‐Feng , Ou Da‐Liang , Chen Pai‐Sheng
Published: January 2019

Hepatocellular carcinoma (HCC) is a lethal human malignancy and a leading cause of cancer‐related death worldwide. Patients with HCC are often diagnosed at an advanced stage, and the prognosis is usually poor. The multikinase inhibitor sorafenib is the first‐line treatment for patients with advanced HCC. However, cases of primary or acquired resistance to sorafenib have gradually increased, leading to a predicament in HCC therapy. Thus, it is critical to investigate the mechanism underlying sorafenib resistance. Transactivation response element RNA‐binding protein 2 (TARBP2) is a multifaceted miRNA biogenesis factor that regulates cancer stem cell (CSC) properties. The tumorigenicity and drug resistance of cancer cells are often enhanced due to the acquisition of CSC features. However, the role of TARBP2 in sorafenib resistance in HCC remains unknown. Our results demonstrate that TARBP2 is significantly downregulated in sorafenib‐resistant HCC cells. The TARBP2 protein was destabilized through autophagic–lysosomal proteolysis, thereby stabilizing the expression of the CSC marker protein Nanog, which facilitates sorafenib resistance in HCC cells. In summary, here we reveal a novel miRNA‐independent role of TARBP2 in regulating sorafenib resistance in HCC cells.
Advertisement–programme congruence in memory of sexual fragrance advertisements
Authors: Wong Hiu Yan Amy , McClelland Alastair , Furnham Adrian
Published: January 2019

The current study explored the effect of sexual content in advertisements and the programme–advertisement congruence on the memory of sexual and nonsexual advertisements. Seventy participants (41 females and 29 males) were randomly allocated to one of four conditions. They viewed either The Bachelorette (sexual programme) or I'm a Celebrity… Get Me Out of Here! (nonsexual programme) with sexual or nonsexual fragrance advertisements placed within the programme. The order of the advertisements was counterbalanced across participants to control for order effects. Free and cued recall of the advertisements were assessed. As predicted, there was a main effect of advertisement type, with the sexual advertisements better recalled than the nonsexual advertisements. Contrary to our prediction, the sexual content of the programme did not have an effect on advertisement recall. There was an interaction between the advertisement type and programme type; sexual advertisements were remembered better when embedded within a sexual programme. Limitations of this study are considered.
Characterization of Special Grain Boundaries and Triple Junctions in CuxNi1‐x Alloys upon Deformation and Annealing
Authors: Emeis Friederike , Leuthold Jörn , Spangenberg Katharina , Peterlechner Martin , Wilde Gerhard
Published: January 2019

We compare two quantities to describe a microstructure: the length fraction of 3/9‐grain boundaries and the number fraction of 3‐x‐x/3‐3‐9‐triple junctions using Cu, Ni and four of their alloys in several microstructural states. The fractions of 3‐grain boundaries show similar tendencies as the respective fractions of 3‐x‐x‐triple junctions in relation to the grain size upon deformation and annealing. However, the fraction of 9‐grain boundaries stagnates at certain grain sizes, while there is still a considerable change of 3‐3‐9‐triple junctions during grain growth, meaning that the 3‐3‐9‐triple junction microstructure is still evolving. To analyze the evolution of the triple junction microstructure, a program, such as pythorient, is necessary.
Perfluorocarbon‐Loaded and Redox‐Activatable Photosensitizing Agent with Oxygen Supply for Enhancement of Fluorescence/Photoacoustic Imaging Guided Tumor Photodynamic Therapy
Authors: Hu DanRong , Zhong Lin , Wang MengYao , Li HaoHuan , Qu Ying , Liu QingYa , Han Ruxia , Yuan LiPing , Shi Kun , Peng JinRong , Qian ZhiYong
Published: January 2019

The wide clinical application of photodynamic therapy (PDT) is hampered by poor water solubility, low tumor selectivity, and nonspecific activation of photosensitizers, as well as tumor hypoxia which is common for most solid tumors. To overcome these limitations, tumor‐targeting, redox‐activatable, and oxygen self‐enriched theranostic nanoparticles are developed by synthesizing chlorin e6 (Ce6) conjugated hyaluronic acid (HA) with reducible disulfide bonds (HSC) and encapsulating perfluorohexane (PFH) within the nanoparticles (PFH@HSC). The fluorescence and phototoxicity of PFH@HSC nanoparticles are greatly inhibited by a self‐quenching effect in an aqueous environment. However, after accumulating in tumors through passive and active tumor‐targeting, PFH@HSC appear to be activated from “OFF” to “ON” in photoactivity by the redox‐responsive destruction of the vehicle's structure. In addition, PFH@HSC can load oxygen within lungs during blood circulation, and the oxygen dissolved in PFH is slowly released and diffuses over the entire tumor, finally resulting in remarkable tumor hypoxia relief and enhancement of PDT efficacy by generating more singlet oxygen. Taking advantage of the excellent imaging performance of Ce6, the tumor accumulation of PFH@HSC can be monitored by fluorescent and photoacoustic imaging after intravenous administration into tumor‐bearing mice. This PFH@HSC nanoparticle might have good potential for dual imaging‐guided PDT in hypoxic solid tumor treatment.
Immunostimulatory Effects Triggered by Self‐Assembled Microspheres with Tandem Repeats of Polymerized RNA Strands
Authors: Kim Dajeong , Kim Hyejin , Han Sangwoo , Scatena Marta , Kim Deok‐Ho , Lee Jong Bum
Published: January 2019

Self‐assembled RNA particles have been exploited widely to maximize the therapeutic potential of RNA. However, the immune response via RNA particles is not fully understood. In addition, the investigation of the immunogenicity from RNA‐based particles is required owing to inherent immunostimulatory effects of RNA for clinical translation. To examine the immune stimulating potency, rationally designed microsized RNA particles, called RNA microspheres (RMSs), are generated with single or double strands via rolling circle transcription. The RMSs show an exceptional stability in the presence of serum, while they are selectively degraded under endolysosomal conditions. With precisely controlled size, both RMSs are successfully taken up by macrophages. Unlike the nature of RNA fragments, RMSs induce only basal‐level expression of inflammatory cytokines as well as type I interferon from macrophages, suggesting that RMSs are immunocompatible in the therapeutic dose range. Taken together, this study could help accelerate clinical translation and broaden the applicability of the self‐assembled RNA‐based particles without being limited by their potential immunotoxicity, while a systematic controllability study observing the release of RNA fragments from RMSs would provide self‐assembled RNA‐based structures with a great potential for immunomodulation.
Artificial Chiral Probes and Bioapplications
Authors: Hao Changlong , Xu Liguang , Kuang Hua , Xu Chuanlai
Published: January 2019

The development of artificial chiral architectures, especially chiral inorganic nanostructures, has greatly promoted research into chirality in nanoscience. The nanoscale chirality of artificial chiral nanostructures offers many new application opportunities, including chiral catalysis, asymmetric synthesis, chiral biosensing, and others that may not be allowed by natural chiral molecules. Herein, the progress achieved during the past decade in chirality‐associated biological applications (biosensing, biolabeling, and bioimaging) combined with individual chiral nanostructures (such as chiral semiconductor nanoparticles and chiral metal nanoparticles) or chiral assemblies is discussed.
Recommended Practices and Benchmark Activity for Hydrogen and Oxygen Electrocatalysis in Water Splitting and Fuel Cells
Authors: Wei Chao , Rao Reshma R. , Peng Jiayu , Huang Botao , Stephens Ifan E. L. , Risch Marcel , Xu Zhichuan J. , Shao‐Horn Yang
Published: January 2019

Electrochemical energy storage by making H2 an energy carrier from water splitting relies on four elementary reactions, i.e., the hydrogen evolution reaction (HER), hydrogen oxidation reaction (HOR), oxygen evolution reaction (OER), and oxygen reduction reaction (ORR). Herein, the central objective is to recommend systematic protocols for activity measurements of these four reactions and benchmark activities for comparison, which is critical to facilitate the research and development of catalysts with high activity and stability. Details for the electrochemical cell setup, measurements, and data analysis used to quantify the kinetics of the HER, HOR, OER, and ORR in acidic and basic solutions are provided, and examples of state‐of‐the‐art specific and mass activity of catalysts to date are given. First, the experimental setup is discussed to provide common guidelines for these reactions, including the cell design, reference electrode selection, counter electrode concerns, and working electrode preparation. Second, experimental protocols, including data collection and processing such as ohmic‐ and background‐correction and catalyst surface area estimation, and practice for testing and comparing different classes of catalysts are recommended. Lastly, the specific and mass activity activities of some state‐of‐the‐art catalysts are benchmarked to facilitate the comparison of catalyst activity for these four reactions across different laboratories.