bluuebunny/crossref_metadata_2025 huggingface dataset:
Hemolysis, icterus and lipemia interfere with the determination of Thiobarbituric Acid Reactive Substances (TBARS) and Total Antioxidant Status (TAS) in canine serum.
Authors: Perez-Montero Blanca , Fermin-Rodriguez Maria Luisa , Miro Guadalupe , de Juan Lucia , Cruz-Lopez Fatima
Published: May 2023

Background
Oxidative stress has been proved to participate in a plethora of human and canine diseases. Among oxidative stress biomarkers, Thiobarbituric Acid Reactive Substances (TBARS) and Total Antioxidant Status (TAS) are two of the most widely used. Pre-analytical factors are highly relevant to obtain accurate results in these assays. Hemolysis, icterus and lipemia (HIL) are among the most frequent sources of pre-analytical errors in the laboratory, but limited information is available on the considerations for canine specimens. Hence, the objective of this study was to assess the potential interferences due to HIL on the determination of TBARS and TAS in canine serum.
Methods
Dilutions of canine pooled serum samples were prepared with increasing concentrations of hemolysate, bilirubin and a synthetic lipid emulsion. TBARS and TAS were determined, and biases from the control value due to the interferents were calculated.
Results
Hemolysis, icterus and lipemia induced significant interferences on TBARS and TAS, to a variable extent depending on the biomarker and interferent. TBARS seemed the most vulnerable method to interferences in this study. Slight hemolysis, moderate icterus and slight lipemia induced significant deviations of TBARS value, exceeding the acceptable interference threshold. TAS assay was also affected by HIL, but to a lesser extent compared to TBARS. Significant biases from TAS control value were observed when icterus was moderate, and hemolysis and lipemia were marked.
Conclusions
TBARS and TAS assays are widely used for oxidative stress evaluation. However, the literature on the interference of HIL on these biomarkers in canine serum is scarce. In light of our results, we conclude that hemolyzed, icteric and lipemic specimens are not suitable for TBARS and TAS determination in canine serum. Our findings seem of considerable practical utility, as a simple visual inspection would be sufficient for discarding these specimens.
Perinatal mental health professionals’ experiences and perceptions of working with mothers who are suicidal during the perinatal period: A reflexive thematic analysis study
Authors: Reid Holly E. , Edge Dawn , Pratt Daniel , Wittkowski Anja
Published: May 2023

Background Suicide is the leading cause of death in mothers postpartum and one of the most common causes of death during pregnancy. As mental health professionals, who work with mothers experiencing suicidal thoughts and behaviour during pregnancy and postpartum, can offer insights into the characteristics of mothers most likely to experience suicidal ideation and behaviour, how they can support these mothers and improve current practices, we aimed to explore mental health professionals’ experiences and perceptions.Method As part of this qualitative study, semi-structured interviews were conducted face-to-face or via telephone with mental health professionals working in perinatal mental health inpatient or community services across England. Data were analysed using reflexive thematic analysis.Results Fifteen professionals took part in this study and two main themes were developed from their interview data. The first theme, identifying the problem(s), overarched three subthemes: 1.1) the mother’s context, 1.2) what the baby represents and what this means for the mother, and 1.3) types of suicidal ideation and attempts. These subthemes described factors that professionals assessed or deemed contributory in relation to suicidal ideation/behaviour when a mother was under their care. The second main theme, reducing suicidal ideation and behaviour, outlined how professionals understood and tried to treat the suicidal ideation/behaviour. This theme encapsulated two subthemes: 2.1) how to talk about suicide and 2.2) changing how a mother views her baby and herself.Conclusion Professionals highlighted many factors that should be considered when responding to a mother’s risk of suicide during the perinatal period, such as the support around her, whether the pregnancy was planned and what the baby represented for the mother. Professionals’ narratives highlighted the importance of adopting a tailored approach to discussing suicidal thoughts, plans and behaviours with mothers to encourage disclosure. Our findings also identified psychological factors that professionals perceived as being linked to suicidal outcomes for mothers, such as self-efficacy and the mother-infant bond; these factors should be investigated further to establish whether mechanisms exist.
Pediatric Blastic Plasmacytoid Dendritic Cell Neoplasm: A Case Report
Authors: Zheng Jasper X. , Betts Elham Vali , Dwyre Denis M. , Chung Jong H. , Mitra Ananya Datta
Published: May 2023

Background:
Herein, we present the second documented case of a rare pediatric lower extremity unilateral unilocular cutaneous BPDCN in a relatively asymptomatic Hispanic child who had unusual initial transient improvement from antibiotic treatment.
Case presentation:
A well-nourished 12-year-old Hispanic male with no significant past medical history developed a sizable progressively enlarging lesion on his right inner calf of approximately two months duration after a ground level fall. Review of systems noted night sweats. All imaging findings were unremarkable except for subcutaneous soft tissue ill-defined infiltrative swelling. Routine laboratory findings were non-contributory. The differential of chronic atypical infectious etiology was initially favored. Interestingly, it did have transient improvement with drainage and antibiotic treatment (Cephalexin/Keflex, 500mg). Approximately two months later, the lesional appearance worsened and patient was eventually diagnosed with blastic plasmacytoid dendritic cell neoplasm.
Conclusion:
Pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive neoplastic process involving precursor plasmacytoid dendritic cells. Diagnostic evaluation of this intricate heterogeneous entity necessitates the incorporation of various clinical and laboratory findings. Given the challenging nature of this entity, it is imperative to arrive at timely diagnosis with tissue biopsy and initiate appropriate prompt management.
Post-migration stressors, mental health and well-being in resettled refugees from Syria: Do individuals’ coping strategies matter?
Authors: Solberg Øivind , Nissen Alexander , Saboonchi Fredrik
Published: May 2023

Background The evidence is mixed as to whether individuals’ coping strategies may mitigate the adverse mental health effects of post-displacement stressors in refugee populations, with some indications that the buffering effects of coping strategies are context dependent. The present study examined if problem-solving and acceptance coping strategies were effect modifiers between post-migration stressors and mental health in adult refugees from Syria resettled in Sweden.Methods Study aims were investigated using cross-sectional survey data from a nationwide, randomly sampled group of adult refugees from Syria resettled in Sweden between 2008 and 2013 (Nsample = 4000, nrespondents = 1215, response rate 30.4%). Post-migration stressors examined included: financial strain, social strain, host-country competency strain and discrimination. Two mental health outcomes were used: anxiety/depression, measured with the Hopkins Symptom Checklist-25; and well-being, measured with the WHO-5 Well-being Index. Both outcomes were modelled continuously. Coping strategies were measured using the BRIEF Cope scale. Interactions between coping strategies and post-migration stressors were tested in fully adjusted linear regression models using Wald test for interaction, corrected for multiple testing using the Benjamini-Hochberg procedure.Results Both problem-solving and acceptance coping strategies buffered the adverse association between financial strain and symptoms of anxiety/depression, and problem-solving coping strategies buffered the adverse association between host-country competency strain and anxiety/depression.Conclusions The study suggests that individuals’ coping strategies may to some degree buffer the adverse mental health effects of financial strain and host-country competency strain experienced by refugees in the resettlement phase. Although this pattern was only found in regard to anxiety/depression and not subjective well-being, the findings show that individual-level coping skills among refugees may contribute to adaptation in the face of post-settlement adversities. Notwithstanding the importance of attending to refugees’ psychosocial conditions, refugees residing in refugee camps and newly resettled refugees might benefit from interventions aiming at enhancing individual coping resources and skills. The potential effect of increased controllability and decreased conflict-proximity also warrants further exploration in future studies
The formation of oscillation patterns based on the planetary gravitational field and their suitability for earthquake prediction.
Authors: Nitsche Michael
Published: May 2023

The fluctuating planetary gravitational field influences not only activities on the Sun but also on the Earth. A special correlation function describes the harmonics of these fluctuations. Groups of earthquakes form oscillation patterns that differ significantly from randomly chosen control groups. These patterns are suitable as an element of an AI for the probability of earthquakes.
In vitro CRISPR screening uncovers CRTC3 as a regulator of IFN-γ-induced ferroptosis of hepatocellular carcinoma
Authors: Li Li , Xing Tao , Chen Yiran , Xu Weiran , Fan Bo , Ju Gaoda , Zhao Jing , Lin Li , Yan Cihui , Liang Jun , Ren Xiubao
Published: May 2023

Interferon gamma (IFN-γ) exerts anti-tumor effects by inducing ferroptosis. Based on CRISPR/Cas9 knockout screening targeting genome-wide protein encoding genes in HepG2 and SK-Hep-1 cell lines, we found that cAMP response element binding protein (CREB) regulated transcription coactivator3 (CRTC3) protects tumor cells from drug induced ferroptosis and significantly inhibits the efficacy of IFN-γ treatment in hepatocellular carcinoma (HCC). Mechanistically, CRTC3 knockout altered tumor cell lipid patterns and increased the abundance of polyunsaturated fatty acids (PUFAs), which enables lipid peroxidation and enhances the susceptibility of HCC cells to ferroptosis inducers. To scavenge for accumulated lipid peroxides (LPO) and maintain redox equilibrium, HCC cells up-regulate SLC7A11 expressions to enhance the activities of glutamate-cystine antiporter (system xc-). As IFN-γ inhibiting system xc-, simultaneous treatment with IFN-γ disrupts the compensatory mechanism, and generates a synergistic effect with CRTC3 knockout to facilitate ferroptosis. Sensitizing effects of CRTC3 depletion were confirmed using typical ferroptosis inducers, including RSL3, erastin and Sorafeinib. In conclusion, CRTC3 is involved in regulation of PUFAs metabolism and ferroptosis. Targeting CRTC3 signaling in combination with ferroptosis inducers present a viable approach for HCC treatment and overcoming drug resistance.
Early Earth microbial metallome: Insights from Cd, Ba, and Ni isotopes in stromatolites
Authors: Hohl Simon , Lv Yiwen , Viehmann Sebastian , Lin Yi-Bo , Jiang Yuxiang , Zhang Yinggang
Published: May 2023

Stromatolitic carbonates are geochemical archives that allow studying the long-term interplay of the biosphere, atmosphere, and hydrosphere through deep time, with the unique potential to investigate early life environments and the evolution of the metallome. Recently non-traditional stable isotopes of bioactive metals emerged as novel proxies to reconstruct the micronutrient cycling in stromatolitic microbial habitats.
This study uses stromatolites from the ~3-billion-year-old Pongola Supergroup (S.-Africa) as a field laboratory for combined in-situ trace metal mapping and layer-specific novel stable metal isotope compositions to determine biogeochemical metal cycling in early Earth microbial habitats. LA ICP-MS maps reveal intrinsic bio-sedimentary enrichments of Ni, Cd, P, Fe and Mn in laminae; in contrast, Ba shows a more heterogeneous distribution. Intra-laminae δ60Ni and δ112Cd follow typical kinetic isotopic fractionation, i.e., the isotopic composition of Cd and Ni evolves to heavier values with decreasing respective element concentrations arguing for carbonate precipitation from a fractionated Ni and Cd pool heavier than ambient silicate rocks. Further correlations of δ112Cd with δ13C and the nutrients Cu, Mo, and P argue for primarily photosynthetic over methanogenic metal uptake. In contrast, δ138Ba records isotope fractionation related to variable aragonite precipitation rates in the stromatolite, i.e., Ba evolves to isotopically heavier values with increasing concentrations under variable alkalinity in the microbial habitat. We show that the combination of Cd and Ni isotopes has unique potential as novel isotope biomarker for early Earth's bio-chemical sediment record where traditional lipid biomarkers are not applicable due to fragmentary preservation of organic material.
Primary Bone Diffuse Large B-cell Lymphoma (PB-DLBCL) – a distinct extranodal lymphoma of germinal center origin, with an EZB-like mutational profile and good prognosis
Authors: Ivanova Vanesa-Sindi , Davies John , Menter Thomas , Wild Damian , Müller Anne , Krasniqi Fatime , Stenner Frank , Papachristofilou Alexandros , Dirnhofer Stefan , Tzankov Alexandar
Published: May 2023

Primary bone diffuse large B-cell lymphoma (PB-DLBCL) is not recognized as a separate entity by the current classification systems. Here, we define and highlight its distinctive clinical presentation, morphology, phenotype, gene expression profile (GEP) and molecular genetics.
We collected 27 respective cases and investigated their phenotype, performed gDNA panel sequencing covering 172 genes, and carried out fluorescence in situ hybridisation to evaluate MYC, BCL2 and BCL6 translocations. We attempted to genetically subclassify cases using the Two-step classifier and performed GEP for cell-of-origin subtyping and in silico comparison to uncover up- and down-regulated genes as opposed to other DLBCL.
Almost all cases (n=22) were germinal center B-cell-like (GCB) by immunohistochemistry and all by GEP. Additionally, PB-DLBCL has a mutational profile similar to follicular lymphoma and nodal GCB-DLBCL, with the exception of TP53 and B2Mmutations. The GEP of PB-DLBCL is unique, and the frequency of BCL2rearrangements is lower compared to nodal GCB-DLBCL. The Two-step classifier categorised 8 of the cases as EZB, 3 as ST2 and 1 as MCD.
This study comprehensively characterizes PB-DLBCL as a separate entity with distinct clinical and morpho-molecular features. These insights may aid in developing tailored therapeutic strategies and shed light on its pathogenesis.
Evaluation of awareness about common eye diseases related to electronic devices use and their risk factors among Syrian university students
Authors: a'raji Zeinab Al , Asadi Natalie Al , Hedde Yusra
Published: May 2023

Introduction: All of us are exposed on a daily basis to many visible and sometimes invisible lights that can cause many damages and risks to our health and the health of those around us. These range from damage to the retina to potential vision loss. So, blue light is one of the factors affecting human health. Blue light is part of the visible light spectrum and consists of electromagnetic particles that travel in waves. These waves emit energy and vary in length and strength. Blue light has a wavelength between about 380 and 500 nanometers, making it one of the shortest and longest wavelengths of energy. This type of waves is emitted from electronic devices. This study aims to determine the awareness of the effects of the waves emitted from electronic devices on the human eye.
Materials and Methods: A descriptive cross-sectional study was conducted on a group of students. We obtained a written consent from all patients in the group. All patients were university students. The study excluded patients who didn’t complete the questionnaire. The study was approved by the Ethical Review Board (IRB) of the Faculty of Medicine in the Syrian Private University.
Results: Out of 1009 students participating in the study, 18.2% were students in the field of human medicine, 28.6% were students in dentistry, 13.5% were students in pharmacy, 16.4% were students in engineering, and 11.1% were students in business administration. 29.3% of the participants were Damascus University students, 39% were Syrian Private University students, and 14.7% were Al-Sham Private University students. 58.1% of the study subjects stated that they relied on the use of electronic lectures in the study, compared to 41.9% who relied on paper lectures.
Conclusion: Additional studies are needed to identify the harm of blue rays that are emitted from electronic devices on the eyes. As well as the need to determine the knowledge and awareness of the harm of light on the eyes.
Spatial distribution and ecological niche modelling of some potential vectors involved in the transmission of Buruli ulcer in Benin (West Africa)
Authors: Pérugine AKOTON Tété , Kourouma KOURA , Jean GANGLO Cossi
Published: May 2023

Buruli Ulcer (BU) is an infectious disease caused by a pathogen, Mycobacterium ulcerans. This mycobacterium is responsible for severe necrosis of subcutaneous tissue leading to chronic ulcers and wounds. However, the distribution of potential reservoirs of this mycobacterium, which is necessary for an effective dynamics control, remains poorly known in Benin. This study aims to model the spread of BU infection risk in Benin. The methodological approach focused on data collection, processing and analysis. Indeed, two data sources were used in the MaxEnt (Maximum Entropy) software to model the spatial distribution of some families of Mycobacterium ulcerans vectors. These are present and future bioclimatic data (scenarios rcp 45 and rcp 85) downloaded from http://webfiles.york.ac.uk/KITE/AfriClim/ and occurrences (234) of the disease from fieldwork and literature. Potential vectors inventoried in the field are aquatic bugs of the family Belostomatidae and Naucoridae and worms whose taxa were not specified. The areas at risk of this disease in the present as well as in the future, globally include the South to the Center Benin and parts of the North-West and North-East of the country. The various results obtained are valuable for prevention and better management of patients. To this end, it will be necessary to focus attention and strengthen control interventions in areas at present and future risk of the disease.
Approximation in morphology: A state of the art
Authors: Masini Francesca , Norde Muriel , Van Goethem Kristel
Published: May 2023

This paper offers a state of the art of approximation within the larger domain of evaluative morphology. It provides an overview of the formal means employed by the morphology of different languages to express approximative meanings, as well as a survey of the specific approximative values that can be conveyed. We further discuss the (input and output) lexical categories involved in the expression of approximation crosslinguistically. On an intralinguistic level, we address the issue of competition between different strategies.
Pseudo(-) in French and Greek: Categorization and approximation
Authors: Vassiliadou Hélène , Gerhard-Krait Francine , Fotiadou Georgia , Lammert Marie
Published: May 2023

Pseudo(-) is generally considered to be a prefix or a prefixoid unit with an evaluative value of pragmatic approximation and negative polarity: pseudo(-)X presents a distortion with respect to a standard X. It then enters the paradigm of   expressions responsible for infusing subjectivity into the discourse. The interpretative mechanisms in play exploit two dimensions, semantic and pragmatic, according to principles that will be explained in this paper. Furthermore, our contribution aims to highlight the semantic dimension in the interpretation of pseudo(-) both in Greek and French and to show how it exploits the semantic and categorial properties of the nouns that are postposed to it, leading to three main types of categorization (pseudo(-)X belongs to the category X but it is not a good exemplar, pseudo(-)X is clearly not an X the categorization remains undecidable) and to several readings.
PENGARUH RASIO LIKUIDITAS, RASIO SOLVABILITAS DAN PROFITABILITAS TERHADAP NILAI PERUSAHAAN SEKTOR INFRASTRUKTUR YANG TERDAFTAR DI BEI TAHUN 2017-2020
Authors: Yulanda Maya Valentina , Sari Nadia Roosmalita
Published: May 2023

Infrastructure companies are companies that contribute to development, this type of company also has good prospects, especially in the global capital market. So in this case a company wants its business to be sustainable and therefore always tries to manage its finances by obtaining, allocating and using it efficiently and effectively, as well as improving the quality of new products and investments. This study aims to determine the effect of liquidity, solvency and profitability on firm value in infrastructure sector companies listed on the Indonesia Stock Exchange in 2017-2020. The method used is a quantitative approach and multiple linear regression analysis, while for the determination of the sample using the purposive sampling method with certain criteria, the number of samples is 10 companies. Testing this data using SPSS 16 software. The results showed that liquidity had no effect on firm value, solvency had a significant effect on firm value, and profitability had a significant effect on firm value.
Majorana lattice gauge theory: Symmetry breaking, topological order and intertwined orders all in one
Authors: Miao Jian-Jian
Published: May 2023

The Majorana lattice gauge theory purely composed of Majorana fermions on square lattice is studied throughly. The ground state is obtained exactly and exhibits the coexistence of symmetry breaking and topological order. The Z_2Z2 symmetry breaking of matter fields leads to the intertwined antiferromagnetic spin order and \etaη-pairing order. The topological order is reflected in the Z_2Z2 quantum spin liquid ground state of gauge fields. The Majorana lattice gauge theory, alternatively can be viewed as interacting Majorana fermion model, is possibly realized on a Majorana-zero-mode lattice.
Investigation of the relationship between glucose potassium ratio and insulin resistance in polycystic ovary syndrome infertile women
Authors: Gürkan Naziye
Published: May 2023

Aim: The aim of this study was to evaluate the relationships between glucose potassium (Glu/K+) ratio and insulin resistance (IR) in infertile women with polycystic ovary syndrome (PCOS). It is necessary to identify a new diagnostic parameter such as Glu/K+ ratio for IR in PCOS patients.

Methods: A total of 198 reproductive-aged women were included in this retrospective case–control study. Women aged 20-39 years diagnosed with infertility and PCOS constituted the PCOS group. Women who were diagnosed with infertility but not PCOS formed the control group.

Result: The age and body mass index (BMI) of the participants were 30.31±4.68 and 26.53±4.80, respectively. Fasting blood glucose was found to be higher in those with a diagnosis of PCOS (p
Manguezais
Authors: Eyzaguirre Indira Angela Luza , Fernandes Marcus Emanual Barroncas
Published: May 2023

A Região Amazônica brasileira tem muitos matizes e um deles é a Amazônia Azul que ainda é pouco conhecida. Nessa extensa área marítima, os manguezais amazônicos são preponderantes e surgem nos estuários dando vida a um sistema socioecológico complexo, onde tudo acontece e as comunidades estuarino-costeiras são dependentes dos serviços ecossistêmicos oferecidos por esses maretórios, os quais se estendem para além de um espaço físico. A maior faixa de manguezal contínua do mundo e a mais conservada está nos estados de Amapá, Pará e Maranhão, esses manguezais salvaguardam conhecimentos, científico e tradicional, além de relações sociais complexas e dinâmicas. Aspectos socioambientais direcionados aos Objetivos de Desenvolvimento Sustentável (ODS) de forma contextualizada sobre o ecossistema manguezal através da fotografia. O presente ensaio visual é o resultado das viagens realizadas nas comunidades estuarino-costeiras nos últimos seis anos que gerou um banco de fotografias. Neste ensaio se apresentam os matizes dos manguezais amazônicos através de cinco contos etnofotográficos que perpassam pelas raízes do manguezal até os espaços rurbanos, que aproxima mais essa zona intermediária onde tudo acontece, onde as comunidades, ecológicas e sociais emergem, adaptam-se, resistem e existem.
The Chimera of TPGS and Nanoscale Lipid Carriers as Lymphatic Drug
Delivery Vehicles to Fight Metastatic Cancers
Authors: Sherif Abdelrahman Y. , Harisa Gamaleldin I. , Alanazi Fars K.
Published: May 2023

The lymphatic system (LS) plays a crucial role in fluid balance, transportation of macromolecules,
and immune response. Moreover, LS is a channel for microbial invasion and cancer metastasis.
Particularly, solid tumors, including lung, breast, melanoma, and prostate cancers, are metastasized
across highways of LS. Subsequently, the fabrication of chimeric lymphatic drug delivery systems
(LDDS) is a promising strategy to fight cancer metastasis and control microbial pandemics. In this regard,
LDDS, in terms of PEG-nanoscaled lipid carriers, elicited a revolution during the COVID-19 pandemic
as cargoes for mRNA vaccines. The drug delivered by the lymphatic pathway escapes first-pass
metabolism and enhances the drug's bioavailability. Ample approaches, including synthesis of prodrugs,
trigging of chylomicron biosynthesis, and fabrication of nanocarriers, facilitate lymphatic drug delivery.
Specifically, nanoscales lipid cargoes have the propensity to lymphatic trafficking. Interestingly, TPGSengineered
nanoscale lipid cargoes enhance lymphatic trafficking, increase tissue permeation, and, specifically,
uptake. Moreover, they overcome biological barriers, control biodistribution, and enhance
organelles localization. Most anticancer agents are non-specific, have low bioavailability, and induced
drug resistance. Therefore, TPGS-engineered nanoscale lipid chimeras improve the therapeutic impact
of anticancer agents. This review highlights lymphatic cancer metastasis, nanoscales lipid cargoes as
LDDS, and their influence on lymphatic trafficking, besides the methods of LDD studies.
Health Tourism Prevalence among Western Balkans Citizens During the COVID-19 Pandemic Period
Authors: Maljichi Drita , Tahirbegolli Bernard , Maljichi Driton , Tahirbegolli Iliriana Alloqi , Spier Troy E. , Kulanić Ahmed , Nasufi Irida Agolli , Kovač-Orlandić Milica
Published: May 2023

Background:

This study seeks to evaluate the prevalence of and the association between receiving medical care abroad and the level of trust that citizens from the Western Balkans—Albania, Bosnia and Herzegovina, Kosovo and Montenegro—have in their healthcare systems.

Methods:

The study is cross-sectional and was carried out during three months (July 25-October 30, 2021) through a self-reported questionnaire administered through the Google Forms platform. The study included approximately two-thousand citizens (N=2,356) aged eighteen (18) to seventy (70).

Results:

More than one-third (37.2%) of respondents stated that they or a relative had received healthcare services abroad during the last twelve (12) months. Citizens of Montenegro had the highest prevalence of receiving healthcare services abroad at 43.8%, followed by those from Bosnia and Herzegovina at 39%. No statistically significant difference was found in the level of trust in the healthcare system in the country between those who received healthcare services abroad (4.41±2.88) (out of 10) and those who did not (4.48±2.81) (t= -0.587, p=0.557).

Conclusion:

We ultimately conclude that more than one-third of the participants in our study have traveled abroad for healthcare purposes, with females, those living in urban areas, and those who have previously had a negative healthcare experience in their home country all being more likely to rely on health tourism.
Herbal Components Inspiring Current Lifestyle Disease Treatment: Role
of Nutraceuticals
Authors: Bansal Khushboo , Sundram Sonali , Malviya Rishabha
Published: May 2023

Nutraceuticals are the foods that are used to prevent and cure diseases. Food and nutrients
are essential for the body's normal function and aid in the maintenance of an individual’s
health and prevent various diseases. Nutraceuticals are medicinal foods that aid in the maintenance
of health, the enhancement of immunity, and the prevention and treatment of specific diseases.
The markets of nutraceuticals are one of the fastest-growing industry segments. The prime
reason for this accelerated market growth lies in the fact that nutraceuticals are low cost, can prevent
diseases to occur, hence, can save the health care cost, have more nutritional value, and many
others. Nutraceuticals can be classified on different foundations based on what they promise, natural
sources, and nutraceutical food available in the market. This article will discuss those classifications
in detail along with the role of nutraceuticals in lifestyle diseases, regulations, market
trends, and prospects of nutraceuticals. The article will also highlight the concern areas which play
as the limiting factor in the nutraceuticals industry growth like lack of quality control, lack of data
on its working, and many other things.
Machine Learning Solution for Orthopedics: A Comprehensive Review
Authors: Hussain Bangash Shah , Imad Muhammad , Abul Hassan Muhammad , Naimullah
Published: May 2023

Bone provides support to the skeletal system, associated with joints, cartilage, and muscles attached to bones to help move the body and protect the human internal organs. Bone fracture is a common ailment in the human body due to external force on the bone. The structure of the bone is disturbed, which causes pain, frailness, and bone not functioning properly. Avulsion fracture, Greenstick fracture, Comminuted fracture, Compression fracture, Simple fracture, and Open fracture are different types of fractures. The literature presents a significant number of research papers covering the detection of different kinds of fractures (wrist, hand, leg, skull, spine, chest, etc.). There are different medical imaging tools available such as X-ray, Magnetic Resonance Imaging (MRI), Computed Tomography (CT) and ultrasound, which detect different types of fractures. This paper represents a review study to discuss various bone fracture detection and classification techniques between fracture and non-fracture bone.
Smart Cane: Obstacle Recognition for Visually Impaired People Based on Convolutional Neural Network
Authors: Hussain Adnan , Ahmad Bilal , Imad Muhammad
Published: May 2023

According to the World Health Organization (WHO), there are millions of visually impaired people in the world who face a lot of difficulties in moving independently. 1.3 billion people are living with some visual impairment problem, while 36 million people are completely visually impaired. We proposed a system for visually impaired people to recognize and detect objects based on a convolutional neural network. The proposed method is implemented on Raspberry Pi. The ultrasonic sensors detect obstacles and potholes by using a camera in any direction and generate an audio message for feedback. The experimental results show that the Convolutional Neural Network yielded impressive results of 99.56% accuracy.
Data Augmentation with Image Fusion Techniques for Brain Tumor Classification using Deep Learning
Authors: Hajji Tarik , Elhassani Ibtissam Elhassani , Masrour Tawfik , Tailouloute Imane , Dourhmi Mouad
Published: May 2023

Brain tumor (BT) is a serious cancerous disease caused by an uncontrollable
and abnormal distribution of cells. Recent advances in deep learning (DL) have helped
the healthcare industry in medical imaging for the diagnosis of many diseases. One of
the major problems encountered in the automatic classification of BT when using
machine learning (ML) techniques is the availability and quality of the learning from
data; these are often inaccessible, very confidential, and of poor quality. On the other
hand, there are more than 120 types of BT [1] that we must recognize. In this paper, we
present an approach for the automatic classification of medical images (MI) of BT
using image fusion (IF) with an auto-coding technique for data augmentation (DA) and
DL. The objective is to design and develop a diagnostic support system to assist the
practitioner in analyzing never-seen BT images. To address this problem, we propose
two contributions to perform data augmentation at two different levels: before and
during the learning process. Starting from a small dataset, we conduct the first phase of
classical DA, followed by the second one based on the image fusion technique. Our
approach allowed us to increase the accuracy to a very acceptable level compared to
other methods in the literature for ten tumor classes. 
Air Quality Variation Associated with Particulate Matter in Major North Indian Cities During Diwali 2020: Susceptible Vehicle for SARS CoV-2 Transmission
Authors: Abraham Ancey , Abbas Insha
Published: May 2023

Air pollution is presumed to exacerbate the COVID-19 pandemic. Previous
studies have emphasized that particulate matter in the air increases the virus’ infectivity
and disease lethality. A study was undertaken to inspect if short-term exposure to
pollutants during firecracker burning on Diwali, 2020, contributed to COVID mortality
rates. Here, air quality variation was monitored concerning PM2.5 and PM10 from 4th-21st November 2020 in the six most polluted cities of North India viz. Delhi, Lucknow,
Greater Noida, Bulandshahr, Ghaziabad and Muzaffarnagar; Focussed largely on
measuring pollutants' concentration pre, post and during the Diwali period, significant
short-term variation in the AQI was observed during the night of Diwali which
remained constant until the next day. The hazardous values recorded for AQI during
the Diwali period indicated non-compliance with the ban imposed by the government
on burning firecrackers in 2017. The study established a weak positive correlation
between temperature and AQI, whereas a negative correlation was established between
AQI and humidity. In the aftermath of the COVID-19 pandemic, short-term variations
in air quality may prove to be critical.
Management of The Dampier Strait Regional Water Conservation Area in Raja Ampat Regency
Authors:   Program Studi Pengelolaan Sumberdaya Pesisir dan Lautan, FPIK-IPB, Bogor, 16680, Saputra F. X. Adi , Yulianda Fredinan , Taryono Taryono ,   Departemen Manajemen Sumberdaya Perairan, FPIK-IPB, Bogor, 16680, Faiza Riana ,   Dinas Ketahanan Pangan, Kelautan dan Pertanian, Provinsi DKI Jakarta, 10720
Published: May 2023

The establishment of conservation areas is a form of conservation and utilization of coastal areas and small islands and their ecosystems in an integrated manner to ensure the existence and sustainability of their resources. This study aims to analyze the implementation of the management of the Dampier Strait water conservation area using the Analytical Network Process (ANP) method. Four important aspects to describe the problems and solutions in this study are sourced from ecological, economic, social, and institutional clusters and sub-clusters. The results of the analysis show that the priority problem of managing the water conservation area in the Dampier Strait area originates from the ecological cluster. The results of the sub-cluster analysis show priority problems, namely: (1) Ecosystem degradation with a value of 0.4529, (2) Community welfare is still low with a value of 0.4361 based on economic aspects, (3) Fishing that is not environmentally friendly with a value of 0 .4089 based on social aspects, and (4) Regulations that have not run optimally from the institutional aspect with a value of 0.3844. Referring to the priority problems in each sub-cluster, the following priority solutions were obtained, namely: (1) Coordinating with a score of 0.5447 from the social aspect, (2) Forming a partnership network with a value of 0.5438 from the institutional aspect, (3) Increased community capacity 0.4351, and (4) Improved ecosystem function with a value of 0.4147 from the ecological aspect.
Micmac Analysis of Improving Social Variables of Expected Years of Schooling (EYS) in Coastal and Non Coastal Areas in Pasangkayu Regency, West Sulawesi
Authors:   Guru Besar Fakultas Perikanan dan Ilmu Kelautan, Universitas Brawijaya, Riniwati Harsuko , Inaba Inaba ,   Departemen Sosial Ekonomi Perikanan dan Kelautan, Universitas Brawijaya, Viantika Risya ,   Departemen Sosial Ekonomi Perikanan, PSDKU Universitas Brawijaya, Galisong Ridwan Danuarta ,   Departemen Sosial Ekonomi Perikanan dan Kelautan, Universitas Brawijaya,   Program Magister Kajian Wanita, Sekolah Pascasarjana Universitas Brawijaya
Published: May 2023

The condition of coastal communities, including the Pasangkayu area, in terms of the Expected Years of Schooling (EYS), is still very vulnerable. This study aims to analyze the key factors of increasing the EYS of the community in the coastal countryside of Pasangkayu Regency. The Matrix of Cross Impact Multiplications Applied to a Classification (MICMAC) methods were used in this study. Respondents are experts sourced from the government, educational institutions, non-governmental organizations and communities in the Coastal Village of Pasangkayu Regency. The results showed that the key factor in increasing the EYS in Coastal Village, Pasangkayu Regency was helping parents. The economic condition of coastal rural communities is still vulnerable, so helping people and being able to go to school is a key factor in increasing the EYS. Institutions related to coastal villages are advised to develop work programs that support research results, namely by increasing the old expectations of coastal community schools through these key factors. One way is to develop a school model for fishermen's children. The strategy is carried out by mobilizing teachers to teach non-formal schools for fishermen's children. Supported by the Education Office in equivalence of diplomas with formal education. EYS, can be increased through the increasing number of elderly school-age population who continue to higher education.
El debate acerca de los intentos de estabilización de precios en Argentina, 1948-1954
Authors: Gómez Mónica , Tossolini Lucas , Calvo Martin
Published: May 2023

Si bien Argentina comenzó a experimentar un problema de inflación desde la Segunda Guerra Mundial, fue a partir de 1948 cuando esta situación se arraigó y las causas se tornaron netamente autóctonas. Por su parte, diversos autores coinciden en sostener que desde ese año se produjo un giro en la visión peronista acerca de la inflación, emprendiendo nuevos esfuerzos para combatirla, sin embargo, tienen posiciones divergentes sobre el diagnóstico hecho por el gobierno y el tipo de política antiinflacionaria puesta en práctica en las diversas etapas entre 1948 y 1954. El objetivo del presente artículo es adentrarnos en este debate historiográfico y tomar una posición en el mismo. Para ello, analizaremos los distintos intentos de estabilización de precios en el período de interés: el decreto de 1948, el Plan de Acción y el decreto de 1949, y el Plan Económico de 1952. Asimismo, examinaremos el comportamiento de las variables cuantitativas involucradas en las normativas, así como también el de las tasas de inflación.

Respecto al primer intento de estabilización de precios, compartimos la visión de quienes sostienen que el decreto de 1948 constituyó un conjunto de medidas de tinte monetaristas. En cuanto al Plan de Acción de 1949 y el nuevo decreto, asentimos que hubo un alejamiento de la visión monetarista de la inflación. Afirmamos que se propuso una regla para la emisión, a través de la implementación del aflojamiento de los redescuentos —por ende, de los créditos—, condicionado por “el desplazamiento del crédito oficial al privado” (Consejo Económico Nacional, 1949, p. 4), sustentado esto último por la Real Bills Doctrine. Finalmente, consideramos que en el Plan Económico de 1952 aparece un nuevo diagnóstico acerca del problema de la inflación: las causas, para el gobierno, fueron el aumento del gasto público y el exceso de consumo privado (esto es, inflación de demanda).
Virtual test bench for computer-aided design of drum dryers based on kinetic laws of the drying process
Authors: Tkach V. V. , Shevtsov A. A.
Published: May 2023

The aim of the study is to create a virtual test bench, consisting of optimal design parameters that provide the maximum approximation of the real drying process to the experimental data.

Method. Methods of modeling, formalized description, optimal design and management of technological processes and productions are applied.

 Result. A virtual test bench has been developed that allows real-time determination of the design parameters of drum-type dryers depending on the kinetic patterns of the drying process of various grain crops. As an object of study, the design of a two-section drum dryer was used, each section of which is equipped with a profile channel nozzle that provides a transverse supply of the drying agent through the pouring movable layer of the dispersed product to be dried. An algorithm for calculating the drying process is presented, which makes it possible to determine the fields of temperature and moisture content of grain in a wide range of regime parameters. With the use of CAD, a computer model of this installation was made with the possibility of autonomous rotation and movement of the drums relative to each other. A diagram of the synchronized operation of the moving elements of the installation under conditions of operational reconfiguration of its design in accordance with changes in the kinetic curves has been drawn up.

Conclusion. The presented virtual test stand adequately and with high accuracy allows simulating the process of drying materials in a drum dryer; allows you to test the operation of a drum dryer at the development stage, conduct experiments with the highest possible accuracy, select the optimal drying modes for various materials with minimal energy consumption.
Экситоны с переносом заряда в ВТСП купратах и никелатах
Authors: Москвин А.С.
Published: May 2023

An analysis of the optical properties of compounds based on 3d elements provides valuable information about the electronic structure of the ground state and low-energy excitations. Thus, we show that the analysis of charge-transfer d-d excitons in the dielectric antiferromagnetic phase of cuprates and metastable low-energy electron-hole EH dimers being a result of their evolution after electron-lattice relaxation, turns out to be very fruitful not only for describing linear and nonlinear optical properties and photoinduced effects, but also to develop a promising model of charge triplets to describe the low-energy electronic structure and T-x phase diagrams of active CuO2 planes in cuprates of the T-La2CuO4 or T’-Nd2CuO4 type, as well as NiO2 planes in nickelates of the RNiO2 type, and their evolution with changes in the main energy parameters.
Спектры люминесценции и необычный температурный сдвиг бесфононной эмиссионной линии V-=SUP=-3+-=/SUP=- в SrTiO-=SUB=-3-=/SUB=-
Authors: Скворцов А.П. , Potuv cek Z. , Bryknar Z. , Dejneka A. , Трепаков В.А.
Published: May 2023

The paper presents the first observation of photoluminescence spectra of V3+ impurity in SrTiO3. The broad band of the observed emission is located in the near IR region and at low temperatures consists of a pronounced zero-phonon line (ZPL) with a maximum at 1157.1 nm (8642 сm-1) at 77 K and developed vibronic sidebands extending to 1450 nm. The observed ZPL is associated with an intracenter 1T2g → 3T1g or a closely located 1Eg → 3T1g emission transition in V3+ (3d2) ions replacing Ti4+ ions. It was found that the temperature shift of zero-phonon line is unusually large and its frequency decreases upon lowering the temperature. The local configuration instability of V3+ ions in the 3T1g ground state caused by soft TO1 temperature-dependent phonon mode present in SrTiO3 is considered as a possible source of the observed unusual temperature shift.
Video Calls as a Replacement for Family Visits During Lockdowns in Aged Care: Interview Study With Family Members
Authors: Kelly Ryan M , Xing Yushan , Baker Steven , Waycott Jenny
Published: May 2023

Background

Lockdowns have been used to prevent the spread of transmissible illnesses such as influenza, norovirus, and COVID-19 in care homes. However, lockdowns deny care home residents supplemental care and the socioemotional enrichment that comes from seeing family members. Video calling has the potential to enable ongoing contact between residents and family members during lockdowns. However, video calls can be considered by some as a poor substitute for in-person visits. It is important to understand family members’ experiences with video calling during lockdowns to ensure the effective use of this technology in the future.

Objective

This study aimed to understand how family members use video calls to communicate with relatives living in aged care during lockdowns. We focused on experiences during the COVID-19 pandemic, which involved extensive lockdowns in aged care homes.

Methods

We conducted semistructured interviews with 18 adults who had been using video calls with relatives living in aged care during pandemic lockdowns. The interviews focused on how participants had been using video calls, what benefits they gained from video-based interactions, and what challenges they encountered when using the technology. We analyzed the data using the 6-phase reflexive approach to thematic analysis by Braun and Clarke.

Results

We developed 4 themes through our analysis. Theme 1 interprets video calling as a medium for the continuation of care during lockdowns. Using video calls, family members were able to provide social enrichment for residents and engaged in health monitoring to uphold residents’ welfare. Theme 2 highlights how video calling extended care by supporting frequent contact, transmitting nonverbal cues that were essential for communication, and negating the need for face masks. Theme 3 interprets organizational issues such as the lack of technology and staff time as impediments to the continuation of familial care through video. Finally, theme 4 highlights the need for 2-way communication, interpreting residents’ unfamiliarity with video calling and their health conditions as further barriers to the continuation of care.

Conclusions

This study suggests that, during restrictions arising from the COVID-19 pandemic, video calls became a medium for enabling family members to continue participating in the care of their relatives. The use of video calls to continue care illustrates their value for families during times of mandatory lockdown and supports the use of video to complement face-to-face visits at other times. However, better support is needed for video calling in aged care homes. This study also revealed a need for video calling systems that are designed for the aged care context.