bluuebunny/crossref_metadata_2025 huggingface dataset:
Intense malarial transmission during the dry season in irrigated rice-growing areas: a case study in Sakassou, Côte d'Ivoire
Authors: Beke Obo Armel-Hermann , Zoh Dounin Danielle , Assi Serge-Brice , Gbalegba Constant N. G. , Assouho Konan Fabrice , Azongnibo Mardoché R. K. , Edi Constant A. V. , Tanoh Antoine M. , Yapi Grégoire Y. , Adja Maurice A.
Published: March 2024

The health district of Sakassou is one of the 83 health districts in Côte d'Ivoire, located in a zone with very high malarial transmission rates, with an incidence rate of ≥40% Therefore, to guide vector control methods more effectively, it was crucial to have a good understanding of the vectors in the area. This study aimed to determine the level of malarial transmission during the dry season in Sakassou, Côte d'Ivoire. Female Anopheles mosquitoes were sampled using human landing catches (HLCs) and pyrethrum spraying catches (PSCs). The larvae were collected using the ‘dipping’ method. A total of 10,875 adult female mosquitoes of Anopheles gambiae were collected. The PCR analysis revealed that all individuals were Anopheles coluzzii. The geographical distribution of potential breeding sites of Anopheles showed the presence of An. coluzzii in all the wetlands of the city of Sakassou. During the dry season, the human-biting rate of An. coluzzii was 139.1 bites/person/night. An exophagic trend was displayed by an adult female of An. coluzzii. The entomological inoculation rate during the dry season was 1.49 infectious bites/person/night. This study demonstrated that An. coluzzii was the main vector of malarial transmission in Sakassou, and the intensity of transmission remains high throughout the dry season.
Meta-Analisis: Pengaruh LKPD berbasis PBL terhadap Kemampuan Berpikir Kritis dan Pemecahan Masalah dalam Fisika
Authors: Muslimin Miftahuljannah , Purwaningsih Endang
Published: March 2024

Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan LKPD berbasis Problem Based Learning terhadap kemampuan berpikir kritis dan pemecahan masalah fisika. Metode penelitian ini adalah meta-analisis. Metode penelitian meta-analisis ini terdiri dari beberapa tahapan, yaitu masalah penelitian, pengumpulan data (studi), pengkodean data, analisis data, dan interpretasi. Sampel penelitian terdiri dari 8 artikel yang sudah memiliki ISSN. Teknik analisis data menggunakan effect size. Hasil meta-analisis diperoleh effect size sebesar 2,1 yang dikategorikan tinggi. Artinya pengaruh penggunaan LKPD berbasis Problem Based Learning dapat meningkatkan kemampuan berpikir kritis dan pemecahan masalah peserta didik dalam pembelajaran fisika sebesar 90%.
NATRIURETIC PEPTIDE: DIAGNOSTIC, PROGNOSTIC, AND CLINICAL RELEVANCE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS, ARTERIAL HYPERTENSION AND OBESITY
Authors: Dunaieva Inna
Published: March 2024

Natriuretic peptides are one of the main biomarkers of chronic heart failure (CHF). The level of NT-proBNP makes it possible to evaluate the negative prognosis in patients with CHF, as well as to monitor the sensitivity of patients with left ventricular dysfunction to the appointment of treatment. The purpose of the study: to study the NT-proBNP biomarker in comorbid patients with hypertension, obesity, type 2 diabetes and determine the relationship with a number of hormonal and biochemical indicators.
Materials and methods: all patients were divided into 4 groups depending on the presence of comorbid pathology in them: patients with hypertension – 1 group – 22 people; patients with hypertension combined with obesity – group 2 – 30 people; Hypertension in combination with type 2 diabetes – group 3 – 31 people; patients with hypertension, type 2 diabetes and obesity – group 4 – 28 people. Determination of the content of N-terminal brain natriuretic peptide (NT-proBNP) in the blood serum of patients was carried out by the immunoenzymatic method on the analyzer "Labline-90" (Austria) using a commercial test system manufactured by the company "Elabscience" (ELISA, China) according to the instructions, which was part of the set.
Conclusions. It was established that in patients with hypertension, hypertension in combination with obesity, hypertension in combination with type 2 diabetes, as well as hypertension in combination with type 2 diabetes and obesity, there is a significant increase in NT-proBNP compared to the indicator of the control group (p<0.05). It has been proven that NT-proBNP has a direct correlation with creatinine (p=0.045), urea (p=0.038), triglyceride level (p=0.027) and cholesterol (p=0.031); direct correlation with the level of HbA1c (r=0.202; p=0.0038). The level of NT-proBNP has a significant predictive value for the risk of developing cardiovascular complications in patients with hypertension.
ЗМІНИ В ТИРЕОЇДНОМУ ГОРМОНАЛЬНОМУ СТАТУСІ ПОРАНЕНИХ В ЗАЛЕЖНОСТІ ВІД ОБ’ЄМУ РАНОВОГО УШКОДЖЕННЯ
Authors: Місюра Катерина , Лурін Ігор , Селюкова Наталія , Бойко Марина , Тиха Інна , Негодуйко Володимир , Калашник Світлана
Published: March 2024

Рановий процес – це складний комплекс місцевих та загальних реакцій організму, що розвиваються у відповідь на пошкодження тканин. Внаслідок розпочатої у лютому 2022 року збройної агресії росії проти України значно зросла кількість осіб, які отримали бойову травму. Швидкість загоєння цих травм та  перебіг ранового процесу залежать від багатьох факторів, одним з яких є тиреоїдний гормональний статус. Вплив гормонів щитоподібної залози на швидкість та особливості загоєння бойових травм не вивчались, що й обумовлює актуальність цього дослідження. Мета дослідження. визначення основних закономірностей між об’ємом ранового ушкодження та змінами рівнів гормонів щитоподібної залози у сироватці крові на різних етапах ранової хвороби.

Матеріали та методи. У досліджені брали участь 30 чоловіків, які отримали поранення м’яких тканин різного об’єму ураження. Вік поранених – 34,2+ 4,3 роки. Середня маса тіла становила 78 ±3,5 кг. Визначались  рівні вільного Т3, вільного Т4 та ТТГ.

Результати. У всіх обстежених осіб рівень вільного Т3 не зазнав статистично значущих змін впродовж усього терміну дослідження у порівнянні із його рівнем у термін на 1-3 добу і знаходився  в діапазоні 3,4-5,2 пмоль/л. У осіб із пораненнями легкого та середнього ступеня важкості рівні вільного Т4 не відрізнялись. Рівні вільного Т4 у осіб із важким пораненням були вірогідно (р<0,05) вищими на усіх етапах дослідження у порівнянні із особами з середнім та легким пораненням. Рівень ТТГ при пораненнях середнього та важкого ступеня зростав (р<0,05) у порівнянні із легкими пораненнями у термін 1-5 день. Але на 14 добу дослідження значення даного показника вірогідно зменшувалося (р<0,05) у обох групах до рівня, однакового із групою осіб, які зазнали поранення легкого ступеня.

Висновки. У обстежених осіб із пораненням важкого та середнього ступеня мало місце вірогідне зростання рівнів ТТГ у термін 1 - 5 доби від поранення, яке супроводжувалось також зростанням рівня вільного Т4. Рівні Т3 вірогідних змін не зазнали.
ХВОРОБА ФАБРІ ЯК СПЕКТР ЛАТЕНТНИХ МУЛЬТИСИСТЕМНИХ ПРОЯВІВ
Authors: Чабанова Анна , Коцюба Олександра , Шульга Ольга
Published: March 2024

Хвороба Фабрі – це X-зчеплена лізосомна хвороба накопичення, яка викликається мутаціями в гені GLA, що призводить до дефіциту α-галактозидази А і прогресуючого накопичення глікосфінголіпідів у різних клітинах організму. Типовими клінічними проявами є акропарестезії, помутніння рогівки, гіпертрофічна кардіоміопатія, гіпогідроз, інсульти, протеїнурія та хронічна ниркова недостатність. Проте відомо і про рідкісні ознаки ендокринної дисфункції. Діагностика відносно проста у чоловіків, проте у жінок вона складніша через високу варіабельність ферментної активності α-галактозидази А. Тому важливо розширювати коло спеціалістів, обізнаних про ознаки даного захворювання, оскільки підвищення клінічної настороженості, якісний огляд та збір сімейного анамнезу є основою раннього виявлення хвороби Фабрі. Лікування на сьогоднішній день полягає в проведенні ферментозамісної терапії рекомбінантною людською α-галактозидазою А. Ми повідомляємо про випадок хвороби Фабрі в пацієнтки 34 років і двох її дітей: сина (16 років) та доньки (19 років).
Representações Sociais sobre "Internacinalização" na/da Educação Superior
Authors: Souza Mateus , Reis Bomfim Natanael
Published: March 2024

O presente artigo tem como objetivo analisar como o pensamento do sujeito sobre o objeto social representado – “internacionalização”[1] – pode contribuir para o fortalecimento desta política na Educação Superior. No estudo utilizamos a abordagem qualitativa fundada na Teoria e Método das Representações Sociais (MOSCOVICI, 1978; JODELET, 2001; ABRIC, 2000; SÁ, 1998; VERGÈS, 1994). A amostragem não probabilística contou com a participação de gestores e docentes que atuam em uma Instituição de Ensino Superior, do Estado da Bahia, totalizando 20 sujeitos que foram informantes em potencial. Para a coleta de dados utilizamos a Técnica de Associação Livre de Palavras (TALP) e entrevista semiestruturada. Os resultados apontam que as representações sociais desses sujeitos, sobre “internacionalização” na Educação Superior, se constroem num processo de ancoragem em seus saberes, cuja mobilidade acadêmica é desencadeada pela cooperação e convênios que, podem contribuir com a produção e difusão do conhecimento globalizado.
 
Palavras-Chave: Representações Sociais; Educação Superior; Política de Internacionalização.
 
[1] Optamos em utilizar aspas na palavra a fim de marcar o termo como o objeto socialmente representado e distingui-lo de outro dentro do texto.
Pesquisa em Educação
Authors: Bianchetti Lucídio , Thiengo Lara Carlette
Published: March 2024

Neste artigo tem-se como objetivo resgatar alguns aspectos dos passos iniciais da organização daquilo que é considerado o embrião da passagem da pesquisa individual para a pesquisa de grupos, em direção às atuais redes de pesquisa, tendo no “Programa Institucional de Internacionalização” (CAPES/PrInt) a sua iniciativa atual mais vistosa. O foco inicialmente são os “Centros Regionais de Pesquisas Educacionais (CRPEs)” (1950-1960) e o “Programa de Intercâmbios” (1981-1992), iniciativas induzidas por políticas públicas. Num segundo momento apresentamos oCAPES/PrInt, como a política atual mais expressiva da passagem do grupo para as redes de pesquisa. Para isso, em termos metodológicos, lançamos mão de levantamento de literatura, análise de documentos e entrevistas. Destaca-se autilização de manifestações de Bernardete Gatti, uma das protagonistas envolvidas na organização e implementação do “Programa de Intercâmbio” e figura de proa na pesquisa educacional brasileira. Em linhas gerais, a pesquisa permite afirmar que, do mix dessas experiências pedagógicas e exigências formais, foi/vai se criando uma cultura de grupo/rede de pesquisa com potencial de passar da indução à práxis incorporada
Assessment of Patient Safety in a Low-Resource Health Care System: Proposal for a Multimethod Study
Authors: Haque Ghazal , Asif Fozia , Ahmed Fasih Ali , Ayub Farwa , Syed Sabih ul Hassan , Pradhan Nousheen Akber , Hameed Malika , Siddiqui Muhammad Muneeb Ullah , Mahmood Shafaq , Zaidi Tahani , Siddiqi Sameen , Latif Asad
Published: March 2024

Background

The high prevalence of adverse events (AEs) globally in health care delivery has led to the establishment of many guidelines to enhance patient safety. However, patient safety is a relatively nascent concept in low- and middle-income countries (LMICs) where health systems are already overburdened and underresourced. This is why it is imperative to study the nuances of patient safety from a local perspective to advocate for the judicious use of scarce public health resources.

Objective

This study aims to assess the status of patient safety in a health care system within a low-resource setting, using a multipronged, multimethod approach of standardized methodologies adapted to the local setting.

Methods

We propose purposive sampling to include a representative mix of public and private, rural and urban, and tertiary and secondary care hospitals, preferably those ascribed to the same hospital quality standards. Six different approaches will be considered at these hospitals including (1) focus group discussions on the status quo of patient safety, (2) Hospital Survey on Patient Safety Culture, (3) Hospital Consumer Assessment of Healthcare Providers and Systems, (4) estimation of incidence of AEs identified by patients, (5) estimation of incidence of AEs via medical record review, and (6) assessment against the World Health Organization’s Patient Safety Friendly Hospital Framework via thorough reviews of existing hospital protocols and in-person surveys of the facility.

Results

The abovementioned studies collectively are expected to yield significant quantifiable information on patient safety conditions in a wide range of hospitals operating within LMICs.

Conclusions

A multidimensional approach is imperative to holistically assess the patient safety situation, especially in LMICs. Our low-budget, non–resource-intensive research proposal can serve as a benchmark to conduct similar studies in other health care settings within LMICs.

International Registered Report Identifier (IRRID)

PRR1-10.2196/50532
Health Behavior Change Intervention Preferences Expressed by American Indian Cancer Survivors From a Southwest Tribal Community: Semistructured Interview Study
Authors: Erdrich Jennifer , Cordova-Marks Felina M , Carson William O , Bea Jennifer W , Montfort William R , Thomson Cynthia A
Published: March 2024

Background

While many factors, including social determinants of health, affect cancer mortality, one modifiable risk factor that may contribute to cancer disparities is obesity. The prevalence of obesity in the American Indian/Alaska Native population is 48.1% per the Centers for Disease Control and Prevention. The overall cancer mortality for the American Indian/Alaska Native population is 18% higher than the White population as reported by the American Cancer Society. Interventions tailored to American Indian/Alaska Native communities that promote healthy lifestyle behaviors after cancer diagnosis and prior to cancer surgery (prehab) might improve cancer outcomes for this population.

Objective

The aim of the study is to characterize the lifestyle behaviors of San Carlos Apache cancer survivors and identify preferences for the adaption of a prehab intervention.

Methods

Semistructured interviews and validated questionnaires were completed with San Carlos Apache cancer survivors (N=4), exploring their viewpoints on healthy lifestyle and cancer risk and preferences for program development. A thematic content analysis was conducted.

Results

Participants had an average BMI of 31 kg/m2 and walked 53 minutes daily. The majority of participants reported a high willingness to change eating habits (n=3, 75%). All 4 reported willingness to participate in a diet and exercise program. Important themes and subthemes were identified: (1) cancer is perceived as a serious health condition in the community (N=4, 100%); (2) environmental exposures are perceived as cancer-causing threats (n=3, 75%); (3) healthy diet, exercise, and avoiding harmful substances are perceived as mitigating cancer risk (n=3, 75%); (4) barriers to healthy habits include distance to affordable groceries (n=3, 75%) and lack of transportation (n=2, 50%); (5) there is high interest in a prehab program geared toward patients with cancer (N=4, 100%); and (6) standard monitoring practiced in published prehab programs showed early acceptability with participants (N=4, 100%).

Conclusions

Collaboration with tribal partners provided important insight that can help inform the adaptation of a culturally appropriate prehab program for San Carlos Apache patients diagnosed with cancer.
Outpatient Video Visits During the COVID-19 Pandemic: Cross-Sectional Survey Study of Patients’ Experiences and Characteristics (Preprint)
Authors: van den Bosch Stefanie C , Van Dalen Demi , Meinders Marjan , van Goor Harry , Bergé Stefaan , Stommel Martijn , van Dulmen Sandra
Published: March 2024

BACKGROUND

During the first lockdown of the COVID-19 pandemic, an exponential increase in video consultations replacing in-person outpatient visits was observed in hospitals. Insight into patients’ experiences with this type of consultation is helpful for a broad, sustainable, and patient-centered implementation of video consultation.

OBJECTIVE

This study aims to examine patients’ experiences with video consultation during the COVID-19 pandemic and identify discriminative patient and consultation characteristics to determine when video consultation is most feasible.

METHODS

A cross-sectional survey study was conducted. Patients aged ≥18 years and scheduled for a video consultation at the outpatient clinic of a Dutch university medical center from August 2020 to December 2020 for all medical specialties were eligible. Patients’ experiences were explored through a study-specific survey using descriptive quantitative statistics. Open-ended questions were qualitatively analyzed and thematically categorized into appreciated aspects and aspects for improvement. Discriminative patient and consultation characteristics were identified using 3 distinctive survey items. Characteristics of patients who scored and those who did not score all 3 items positively were analyzed using binary logistic regression.

RESULTS

A total of 1054 patients were included in the analysis. Most patients (964/1054, 91.46%) were satisfied with their video consultation, with a mean overall grade of 8.6 (SD 1.3) of 10. In the qualitative analyses, 70.02% (738/1054) of the patients cited aspects they appreciated and 44.97% (474/1054) mentioned aspects for improvement during their consultation. Patients with better self-rated health reported a positive evaluation significantly more often (P=.001), which also held true for other medical specialties (vs surgical and nonsurgical specialties; P<.001).

CONCLUSIONS

Video consultation was perceived as highly satisfactory by patients during the COVID-19 pandemic, with the best experience reported by healthy participants and those undergoing their first consultation. Appreciated aspects are mainly at the individual professional level, organizational level, and innovation level itself. The aspects that were mentioned for improvement can be changed for the better.
Assessment of Patient Safety in a Low-Resource Health Care System: Proposal for a Multimethod Study (Preprint)
Authors: Haque Ghazal , Asif Fozia , Ahmed Fasih Ali , Ayub Farwa , Syed Sabih ul Hassan , Pradhan Nousheen Akber , Hameed Malika , Siddiqui Muhammad Muneeb Ullah , Mahmood Shafaq , Zaidi Tahani , Siddiqi Sameen , Latif Asad
Published: March 2024

BACKGROUND

The high prevalence of adverse events (AEs) globally in health care delivery has led to the establishment of many guidelines to enhance patient safety. However, patient safety is a relatively nascent concept in low- and middle-income countries (LMICs) where health systems are already overburdened and underresourced. This is why it is imperative to study the nuances of patient safety from a local perspective to advocate for the judicious use of scarce public health resources.

OBJECTIVE

This study aims to assess the status of patient safety in a health care system within a low-resource setting, using a multipronged, multimethod approach of standardized methodologies adapted to the local setting.

METHODS

We propose purposive sampling to include a representative mix of public and private, rural and urban, and tertiary and secondary care hospitals, preferably those ascribed to the same hospital quality standards. Six different approaches will be considered at these hospitals including (1) focus group discussions on the status quo of patient safety, (2) Hospital Survey on Patient Safety Culture, (3) Hospital Consumer Assessment of Healthcare Providers and Systems, (4) estimation of incidence of AEs identified by patients, (5) estimation of incidence of AEs via medical record review, and (6) assessment against the World Health Organization’s Patient Safety Friendly Hospital Framework via thorough reviews of existing hospital protocols and in-person surveys of the facility.

RESULTS

The abovementioned studies collectively are expected to yield significant quantifiable information on patient safety conditions in a wide range of hospitals operating within LMICs.

CONCLUSIONS

A multidimensional approach is imperative to holistically assess the patient safety situation, especially in LMICs. Our low-budget, non–resource-intensive research proposal can serve as a benchmark to conduct similar studies in other health care settings within LMICs.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/50532
Evaluating the Impacts of Community-Campus Engagement on Population Health in Ottawa and Thunder Bay, Canada: Protocol for a Mixed Methods Contribution Analysis (Preprint)
Authors: Buetti David , Larche Cynthia , Fitzgerald Michael , Bourgeois Isabelle , Cameron Erin , Carr Kady , Aubry Tim , Persaud Sydney , Kendall Claire E
Published: March 2024

BACKGROUND

Municipalities play a crucial role in population health due to their community connections and influence on health determinants. Community-campus engagement (CCE), that is, collaboration between academic institutions and communities, is a promising approach to addressing community health priorities. However, evidence of CCE’s impact on population health remains limited. Measuring the impacts of CCE is inherently complex due to factors such as diverse stakeholders, context-specific variables, and dynamic interactions within a community.

OBJECTIVE

This study aims to develop robust evidence on the impacts of CCE on population health outcomes in Ottawa and Thunder Bay, Ontario, Canada, focusing on 5 shared health priorities: housing, discrimination, poverty, violence, and mental health.

METHODS

We will use a proven CCE model called CityStudio, which has been implemented in both cities. We will use Mayne's mixed methods contribution analysis in three stages: (1) formulating a theory of change that outlines the expected contributions of CCE to population health outcomes; (2) gathering qualitative and quantitative data in line with the established Theory of Change; the data will be collected from various sources, including case studies of existing CityStudio projects, a web-based CCE stakeholder survey, a literature review, and population and community health data; and (3) reviewing the gathered evidence to determine the extent of CCE impacts on population health.

RESULTS

Ethical approval for this project was granted in May 2023. We have since initiated stage 1 by reviewing the literature to inform the development of the theory of change. We expect to complete this study by May 2026.

CONCLUSIONS

This study will address two critical gaps about how improving health outcomes depends on CCE: (1) how academic institutions can best engage with their communities to improve population health outcomes, and (2) how municipalities can engage with academic institutions to address their community health priorities. Conducting our work in differing contexts will allow us to consider a broader range of other influences on outcomes, thus making our work applicable to various settings and outcomes.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/58546
Evaluation of comparative efficacy of Navak Guggulu as against Vachaharidradi Gana Vati in the management of Sthaulya (Overweight) in children: A Randomized Controlled Trial (Preprint)
Authors: Fadnavis Kavita Kishor , Rathi Renu Bharat , Ratnaparkhi Karuna Sunil , Ratnaparkhi Karuna Sunil , Rathi Bharat , Deshmukh Paresh Rameshrao , Deshmukh Paresh Rameshrao
Published: March 2024

BACKGROUND

Background: Urbanization & industrialization is contributing to the change in the lifestyle and food preferences especially in children. Childhood obesity is mainly a lifestyle-oriented disorder. It is a rising global burden with its lifelong implications. If not treated in childhood period, it may land up in adulthood with serious complications. In Ayurveda, Sthaulya is the condition which can be referred to obesity. Being over-obese is termed as Atisthula which is a santarpanottha (overnutrition) vyadhi (disorder) and is counted under eight censurable physiques. Treatment of Sthaulya is Karshana (Therapeutic Scrapping). Navak guggulu’s efficacy is already proven for treatment of Obesity. Vachaharidradi gana is a group of Karshana herbs mentionaed in Ashtang Hriday. So, in this study the efficacy of Vachahardidradi gana vati will be compared with Navak guggulu to treat overweight children.

OBJECTIVE

Evaluation of the efficacy of Navak Guggulu along with diet restriction and Suryanamaskara versus Vachaharidradi Gana Vati along with diet restriction and Suryanamaskara in children (10 – 16 years) with Sthaulya (Overweight).

METHODS

After doing the drug analysis, a total of 86 overweight children fitting into inclusion criteria from 10 to 16 years of the age group will be selected and will be distributed in 2 groups having 43 each. One group will be trial group and other group will be control group. Control group will be given Navak Guggulu and trial group will be given Vachahardiradi gana vati tablet. The medicines will be provided to subjects in double blinding manner. Both the groups will receive medicines for 90 days along with diet restriction and Suryanamaskara and they will be followed up every 15 days and their assessment during each visit will be recorded in the case record form. Final follow-up will on 180th day.

RESULTS

Results will be drawn from the observations of subjective and objective parameters.

CONCLUSIONS

Conclusion of the study will be drawn based on statistical data calculated from the collected data and overall improvement.

CLINICALTRIAL

CTRI No. - CTRI/2023/03/051135 (clinical trial registry India)
Dated –28/03/2023
Self-Management Systems for Patients and Clinicians in Parkinson Care: Protocol for an Integrated Scoping Review, Product Search, and Evaluation (Preprint)
Authors: Boege Selina , Milne-Ives Madison , Meinert Edward , Carroll Camille
Published: March 2024

BACKGROUND

Parkinson disease (PD) poses emotional and financial challenges to patients, families, caregivers, and health care systems. Self-management systems show promise in empowering people with PD and enabling more control over their treatment. The collaborative nature of PD care requires communication between patients and health care professionals. While past reviews explored self-management systems in PD diagnosis and symptom management with a focus on patient portals, there is limited research addressing the interconnectivity of systems catering to the needs of both patients and clinicians. A system’s acceptability and usability for clinicians are pivotal for enabling comprehensive data collection and supporting clinical decision-making, which can enhance patient care and treatment outcomes.

OBJECTIVE

This review study aims to assess PD self-management systems that include a clinician portal and to determine which features enhance acceptability and usability for clinicians. The primary aim is to assess evidence of clinicians’ acceptability and usability of self-management systems with a focus on the integration of systems into clinical workflows, data collection points, monitoring, clinical decision-making support, and extended education and training.

METHODS

The review will entail 3 separate stages: a literature review following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines, a product search, and an evaluation of the level of evidence for the identified products. For the first stage, 5 databases will be searched: PubMed, CINAHL, Scopus, ACM digital library, and IEEE Xplore. Studies eligible for inclusion will be qualitative, quantitative, and mixed methods studies examining patients’ and clinician’s perceptions of the acceptability and usability of digital health interventions, synthesized by a narrative qualitative analysis. A web search in the iOS Apple App Store and Android Google Play Store will identify currently available tools; the level of evidence for these will then be assessed using the Oxford Centre for Evidence-Based Medicine guidelines.

RESULTS

Literature search and screening began soon after submission of the protocol, and the review is expected to be completed by end of September 2024.

CONCLUSIONS

This review will examine currently available self-management systems in PD care, focusing on their acceptability and usability. This is significant because there is limited research addressing the integration of clinicians into these systems. The findings from this study may provide critical knowledge and insight to help inform future research and will contribute to the design of self-management systems that promote collaborative efforts in PD care.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/58845
Antipsychotic-associated neuroleptic malignant syndrome (NMS) in schizophrenia patients: a narrative review
Authors: Puspita Okta , Bambang Hastha Yoga  , Zullies Ikawati
Published: March 2024

Neuroleptic malignant syndrome (NMS) is a neurological disorder with an high mortality rate among schizophrenia patients who receive antipsychotics as the primary long-term therapy. Appropriate selection of antipsychotics in NMS should be carefully considered to obtain maximal effectiveness with minimal side effects. An evaluation of the safety profile of the antipsychotics is important due to their different treatment patterns and rapid onset of symptoms. This review article aimed to compare the safety profile of antipsychotics in relation to NMS in schizophrenia patients. It was a narrative review using multiple search engines included PubMed, Google Scholar, and Springer to collect publications from 2007 to 2023. Of the total 14 articles reviewed, 7 articles explained the role of antipsychotics in NMS, 5 articles about the onset of NMS, and 7 articles about mortality rate. The incidence of NMS was less then 0.11%, typical antipsychotics were the most common cause of NMS, especially high-potency antipsychotics compared with atypical antipsychotics. Meanwhile, the onset of NMS consistently occured within 30 d of antipsychotic initiation with a symptom duration of 1 to 30 d, and the mortality rate was also higher for typical antipsychotics. In conclusion, the choice of antipsychotics must be carefully considered and its use must be monitored due to the rapid onset and high mortality. The use of antipsychotics is not free from the risk of NMS. The heterogeneous symptoms of NMS require earlier detection to reduce disease progression.
The Role of Machine Learning in Digital Transformation
Authors: Puranik Dr. Gurusiddayya S.
Published: March 2024

Abstract: Today machine learning it is the part of our daily life. Machine learning is making our day to day life easy from selfdriving cars to Amazon History of Machine Learning virtual assistant "Alexa". However, the idea behind machine learning is so old and has a long history. Below some milestones are given which have occurred in the history of machine learning .The field of machine learning has made significant strides in recent years, and its applications are numerous, including self-driving cars, Amazon Alexa, Catboats, and the recommended system. It incorporates clustering, classification, decision tree, SVM algorithms, and reinforcement learning, as well as unsupervised and supervised learning. Present day AI models can be utilized for making different expectations, including climate expectation, sickness forecast, financial exchange examination, and so on.
Quantum state preparation via engineered ancilla resetting
Authors: Puente Daniel Alcalde , Motzoi Felix , Calarco Tommaso , Morigi Giovanna , Rizzi Matteo
Published: March 2024

In this theoretical investigation, we examine the effectiveness of a protocol incorporating periodic quantum resetting for preparing ground states of frustration-free parent Hamiltonians. This protocol uses a steering Hamiltonian that enables local coupling between the system and ancillary degrees of freedom. At periodic intervals, the ancillary system is reset to its initial state. For infinitesimally short reset times, the dynamics can be approximated by a Lindbladian whose steady state is the target state. For finite reset times, however, the spin chain and the ancilla become entangled between reset operations. To evaluate the protocol, we employ Matrix Product State simulations and quantum trajectory techniques, focusing on the preparation of the spin-1 Affleck-Kennedy-Lieb-Tasaki state. Our analysis considers convergence time, fidelity, and energy evolution under different reset intervals. Our numerical results show that ancilla system entanglement is essential for faster convergence. In particular, there exists an optimal reset time at which the protocol performs best. Using a simple approximation, we provide insights into how to optimally choose the mapping operators applied to the system during the reset procedure. Furthermore, the protocol shows remarkable resilience to small deviations in reset time and dephasing noise. Our study suggests that stroboscopic maps using quantum resetting may offer advantages over alternative methods, such as quantum reservoir engineering and quantum state steering protocols, which rely on Markovian dynamics.
Plot Analysis of Poe’s “The Tell-Tale Heart”
Authors: Putri Putu Evitya Tundari , Malini Ni Luh Nyoman Seri
Published: March 2024

This research is a plot analysis of "The Tell-Tale Heart" by Poe. This research purpose is to analyze the types of plots and analyze the plot structure in "The Tell-Tale Heart" short story. Research data is extracted from Edgar Allan Poe's short story "The Tell-Tale Heart". The method used in data collection is the qualitative method. This study also used theories proposed by Kenney. "The Tell-Tale Heart" is taken because the event in the story begins with the event in the present time, to the next event which is a flashback that supports the first event. Then, proceed back again from the flash-back to the present time. The plot structure has some parts, namely: 1. beginning, 2. middle, 3. end. The beginning of a story is an initial stage that shows the characters in the story, the setting of time and places as well as what the story is about. The middle part contains conflict, complications, and climax.
Total controllability for noninstantaneous impulsive conformable fractional evolution system with nonlinear noise and nonlocal conditions
Authors: Ahmed Hamdy
Published: March 2024

Noninstantaneous impulsive conformable fractional stochastic differential
equation with nonlinear noise and nonlocal condition via Rosenblatt process
and Poisson jump is studied in this paper. Sufficient conditions for
controllability for the considered problem are established. The required
results are obtained based on fractional calculus, stochastic analysis,
semigroups and Sadovskii?s fixed point theorem. In the end paper, an example
is provided to illustrate the applicability of the results.
Weighted Schrödinger-Kirchhoff type problem in dimension 2 with non-linear double exponential growth
Authors: Baraket Sami , Jaidane Rached
Published: March 2024

In this work, we study the weighted Kirchhoff problem {g(?B(?(x)|?u|2 + V(x)u2)dx) [?div(?(x)?u) + V(x)u] = f (x, u) in B u > 0 in
B u = 0 on ?B, where B is the unit ball in R2, ?(x) = log e |x| , the
singular logarithm weight in the Trudinger-Moser embedding, g is a
continuous positive function on R+ and the potential V is a continuous
positve function. The nonlinearities are critical or subcritical growth in
view of Trudinger-Moser inequalities. We prove the existence of non-trivial
solutions via the critical point theory. In the critical case, the
associated energy function does not satisfy the condition of compactness. We
provide a new condition for growth and we stress its importance to check the
min-max compactness level.
Separation and Identification of Microfibers in the Wastewater of Textile Finishing Process
Authors: Akyıldız Sinem Hazal , Yalcin Enis İpek , Sezgin Hande , Bellopede Rossana , Fiore Silvia , Yalcin Bahattin
Published: March 2024

Microplastic pollution is an important global problem caused by the textile industry, which accounts for 35% of microplastics emitted as microfibers (MFs). Microplastics interact with a variety of organisms due to their small dimensions, leading to chromosomal mutations. The goal of this research is to identify and separate microfibers discharged by textile finishing machinery, which is used to give textiles a soft touch. Within the scope of the study, wastewater samples were taken separately in February and March 2022, right after the device exit, before being discharged to the factory effluent and pre-treated for 5 days at 25 °C with 15% H2O2. Then, the microfibers were separated from the wastewater with the help of a filter. The accumulated microfibers on the filters were examined using a light microscope, and their chemical composition was determined using micro-FTIR analysis. Furthermore, energy dispersive X-ray scanning electron microscopy (EDX/SEM) was used for analyzing the structure of microfibers. The findings revealed the presence of acrylic and cotton microfibers in the wastewater samples, with varying concentrations observed on different dates (0.058 g/L and 0.251 g/L), emphasizing the severity of the microplastic issue we currently face.
Risk of mortality and cause of death according to kidney function parameters: a nationwide observational study in Korea
Authors: Jung Sehyun , Lee Soojin , Kim Yaerim , Cho Semin , Huh Hyuk , Kim Yong Chul , Han Seung Seok , Lee Hajeong , Lee Jung Pyo , Joo Kwon Wook , Lim Chun Soo , Kim Yon Su , Kim Dong Ki , Han Kyungdo , Park Sehoon
Published: March 2024

Background: Further study is warranted to determine the association between estimated glomerular filtration rate (eGFR) or albuminuria and the risk of death from diverse causes. Methods: We screened >10 million general health screening examinees who received health examinations conducted in 2009 using the claims database of Korea. After the exclusion of those previously diagnosed with renal failure and those with missing data, 9,917,838 individuals with available baseline kidney function measurements were included. The primary outcome was mortality and cause-specific death between 2009 and 2019 identified through death certificates based on the diagnostic codes of International Classification of Diseases, 10th revision. Multivariable Cox regression analysis adjusted for various clinicodemographic and social characteristics was used to assess mortality risk. Results: The hazard ratio of death was significantly high in both the eGFR <60 mL/min/1.73 m2 and in the eGFR ≥120 mL/ min/1.73 m2 groups in univariable and multivariable regression analyses when compared to those within the reference range (eGFR of 90–120 mL/min/1.73 m2). The results were similar for death by cardiovascular, cancer, infection, endocrine, respiratory, and digestive causes. We also found that albuminuria was associated with higher risk of death regardless of eGFR range, and those in the higher categories of dipstick albuminuria showed higher risk. Conclusion: We reconfirmed the significant association between eGFR, albuminuria, and mortality. Healthcare providers should keep in mind that albuminuria and decreased eGFR as well as kidney hyperfiltration are independent predictors of mortality.
Circulatory endostatin level and risk of cardiovascular events in patients with end-stage renal disease on hemodialysis
Authors: Kim Jin Sug , Kim Miji , Jeong Kyung Hwan , Moon Ju-Young , Lee Sang Ho , Ko Gang Jee , Lee Dong-Young , Lee So Young , Kim Yang Gyun , Hwang Hyeon Seok
Published: March 2024

Background: Endostatin is released during extracellular matrix remodeling and is involved in the development of vascular pathology and cardiovascular (CV) disease. However, the role of circulating endostatin as a biomarker of vascular calcification and CV events in patients undergoing hemodialysis (HD) remains unclear. Methods: A total of 372 patients undergoing HD were prospectively recruited. Plasma endostatin levels were measured at baseline, and their associations with circulating mineral bone disease (MBD) biomarkers and abdominal aortic vascular calcification scores were analyzed. The primary endpoint was defined as a composite of CV and cardiac events. Results: Plasma levels of patients in endostatin tertile 3 were significantly associated with low-density lipoprotein cholesterol levels and predialysis systolic blood pressure in multivariate analysis. However, endostatin levels did not correlate with circulating MBD biomarkers or vascular calcification scores. Patients in endostatin tertile 3 had a significantly higher cumulative event rate for the composite of CV events (p = 0.006). Endostatin tertile 3 was also associated with an increased cumulative rate of cardiac events (p = 0.04). In multivariate Cox regression analyses, endostatin tertile 3 was associated with a 4.37-fold risk for composite CV events and a 3.88-fold risk for cardiac events after adjusting for multiple variables. Conclusion: Higher circulating endostatin levels were independently associated with atherosclerotic risk factors but did not correlate with MBD markers or vascular calcification. Higher circulating endostatin levels were associated with a greater risk of composite CV events in patients undergoing HD, and endostatin is a biomarker that helps to determine the high risk of CV events.
Identification of Precursors of MDMA in Unknown Substances in Sri Lanka
Authors: Jayasekera Vajira Suranji
Published: March 2024

Government Analyst’s Department of Sri Lanka has observed a significant increase in the number of court case samples received for the analysis with regards to the synthetic drugs, amphetamine type stimulants (ATS), and synthetic cannabinoids recently. ‘Ecstasy’ or 3,4-methylenedioxymethampthetamine (MDMA) is an amphetamine type, synthetic and psychoactive drug. The main precursors used for the synthesis of MDMA was 3,4- methylenedioxyphenyl- 2-propernone (3,4-MDP-2-P), Safrole and Isosafrole. The global control of the precursor compound led to decrease in the market supply of these drugs. The case containing four polysac bags marked 1, 2, 3 and 4 respectively with white powder suspected to be MDMA was submitted to the Narcotic Laboratory of the Government Analyst’s Department (GAD) of Sri Lanka by the 0fficers of the Police Narcotic Bureau (PNB) for further examination of narcotic drug if any. After the extraction of the samples comprehensive analytical scheme including TLC, GC-MS and RAMAN spectroscopy was applied for the qualitative analysis. The results obtained from GCMS method confirmed the presence of 3,4-methlenedioxyphenyl-2-propernone (MDP-2-P) in the unknown substances in four samples and Isosafrole glycol in the sample no 1and 2. This is the first time 3,4-MDP-2-P and Isosafrole glycol was identified in the Narcotic Laboratory of the Government Analyst’ s Department. However, MDP -2-P and Isosafrole are precursor Chemicals listed in the Table 1 of first schedule of the convention Against illicit Traffic in Narcotic Drugs and psychotropic substance Act No.1 of 2008 in Sri Lanka. The majority of the precursor chemicals that can be used in the illicit manufacture of synthetic drugs have widespread licit use in the chemical and pharmaceutical industries. As such, their diversion from licit trade by drug trafficking organizations is the primary source of precursor chemicals used in the illicit manufacture of synthetic drugs.
John Lennon and the Unraveling of his Symbiotic Bond with Yoko, on “Double Fantasy”
Authors: Moskowitz Jeff
Published: March 2024

Lennon’s comeback “Double Fantasy” album is a brilliantly conceived and painfully honest musical dialogic between he and Yoko as they confront the realities of growing older
Innovative Bamboo Bowling Game to Improve Motor Skills in Early Childhood
Authors: Anak Agung Ayu Mega Laksmi Febriantari  , Anadhi I Made Gede , Sindu Putra Ida Bagus Komang
Published: March 2024

The need for educational game tools to stimulate children's gross motor skills is one of the limitations of teachers. This research aims to create an innovative bamboo bowling game to improve children's gross motor skills. The research method uses the ADDIE approach development method. Observation, interviews, and literature collected data. The research subjects consisted of 3 experts in relevant fields. The tool used to analyze research results is a questionnaire. This research was analyzed descriptively and quantitatively using Lawshe's content validation formula, the Content Validity Ratio (CVR). From the results of the expert assessment, the CVR value obtained was 0.99, and the CVI value was 0.99. All media experts gave a CVR value of 0.99. Therefore, Innovative Bamboo Bowling is considered valid. Based on these findings, Innovative Bamboo Bowling is suitable for early childhood learning activities in developing gross motor skills and can have goals that focus on improving children's physical and cognitive skills in a fun and beneficial environment. The implications of this research can be the basis for developing intervention programs or gross motor stimulation activities that are more effective and targeted.
Model Project for Pancasila Students in Kindergarten
Authors: Dadan Suryana  , Ayu Ayu Mustika Sari , Farida Mayar  , Nurbiana Dhieni  , Sri Wulan
Published: March 2024

The research results show that children's development in kindergarten is still low because learning in kindergarten should emphasize children's active involvement in working on projects that are implemented in children's play activities. This research aims to develop the Pancasila Student Project model with the aim of improving children's development. This research uses development research (R&D), Plomp design and development. The objects in this research were 33 children. Data collection methods use observation, interviews and questionnaires. Instruments used in preliminary research, prototyping phase, and assessment phase of the Pancasila student model project to improve children's development. The technique used to analyze data is qualitative and quantitative descriptive analysis. The results of the research, namely the prototyping phase, obtained syntax, social systems, action principles, support systems, instructional impacts and accompanying project models to strengthen the profile of Pancasila students. The assessment phase of the validity test is (87), (91), and (93) criteria are very valid. The practicality test of observing the implementation of the learning model obtained an average of 87 model practicalities according to the teacher with very practical criteria. Based on this, the Pancasila Student Project model is suitable for use in learning.
Marbel Application Based Learning Media to Develop Analytical Skills in Children Aged 4-5 Years
Authors: Fitri Elisa , Dewa Gede Firstia Wirabrata
Published: March 2024

Lacking the necessary facilities and tools in schools, teachers sometimes only use one medium to teach. Teachers also experience difficulties introducing the media to students, considering that children still need to learn numbers and initial number symbols. This research aims to create learning media based on marble applications to develop analytical skills in group B children. The development model used in this research is the ADDIE development model. The data collection method uses questionnaires and assessment tools (assessment forms). Analysis techniques with quantitative and qualitative analysis. Based on the content validity test by two experts, the content validity value was 0.93, where this value is classified as very high validity. The Marble fun numbers game application is suitable for developing children's analytical skills. The results of the effectiveness trial showed that the average value of the analysis ability of the small group of children after learning to use marble fun numbers was 80.2%, and the large group's total score was 81%; this was classified as very good. It was concluded that the marble application-based learning media for developing analytical skills in group B children was highly valid. Hence, the marble application-based development media for developing analytical skills in group B children was suitable.