bluuebunny/crossref_metadata_2025 huggingface dataset:
Fabrication and Physico-mechanical Characterization of Short Natural/Synthetic Fiber–Reinforced Hybrid Composites: Effects of Biodegradation and Chemical Aging
Authors: Rahman S. , Das Subrata C. , Saha J. , Khan Mubarak A.
Published: April 2024

The main goal of this study was to develop eco-friendly and low-cost multiple short natural fiber-reinforced hybrid composites with the hybridization of comparatively high-strength glass fibers. The hybrid composites were fabricated via hand lay-up by using short jute, silk, water hyacinth, and glass fibers for the reinforcements and unsaturated polyester resin for the thermoset polymer matrix. The reinforcing fibers were randomly oriented, and five types of hybrid composites were fabricated with different types of fiber content (wt.%). The performance of the manufactured hybrid composites was assessed by tensile, flexural, and impact testing, as well as water uptake (%). It was revealed that composites with high glass fiber content (wt.%) exhibited optimum mechanical performance in most cases, while poor moisture resistance performance was exhibited for the hybrid composites containing higher natural fibers (wt.%). The hybrid composite samples were also aged in soil medium (biodegradation) for 25 days and different chemical solutions (alkaline, acidic, and salt) for 10 days. After biodegradation, the drop of tensile strength (TS) and tensile modulus (TM) was revealed to be approximately 38–61 and 58–72%, respectively. On the other hand, after chemical aging, the drop of TS and TM was exhibited to be approximately 49–76% and 51–65%, respectively, for alkali solution aging; 42–75% and 29–76%, respectively, for acid solution aging; and 43–59% and 51–65%, respectively, for salt solution aging.
Sustainable EnergySense: a predictive machine learning framework for optimizing residential electricity consumption
Authors: Al-Rajab Murad , Loucif Samia
Published: April 2024

In a world where electricity is often taken for granted, the surge in consumption poses significant challenges, including elevated CO2 emissions and rising prices. These issues not only impact consumers but also have broader implications for the global environment. This paper endeavors to propose a smart application dedicated to optimizing the electricity consumption of household appliances. It employs Augmented Reality (AR) technology along with YOLO to detect electrical appliances and provide detailed electricity consumption insights, such as displaying the appliance consumption rate and computing the total electricity consumption based on the number of hours the appliance was used. The application utilizes Linear Regression as a machine learning (ML) algorithm to develop the electricity consumption forecasting model for the next months, based on past utility bills. Linear regression is often considered one of the most computationally lightweight ML algorithms, making it suitable for smartphones. The application also offers users practical tips for optimizing their electricity consumption habits.
An Algorithm for the Recognition of Motion-Blurred QR Codes Based on Generative Adversarial Networks and Attention Mechanisms
Authors: Dong Hao , Liu Haibin , Li Mingfei , Ren Fujie , Xie Feng
Published: April 2024

Motion blur can easily affect the quality of QR code image, making it difficult to recognize QR codes on moving objects. This paper proposes an algorithm for the recognition of motion-blurred QR codes based on generative adversarial network and attention mechanism. Firstly, a multi-scale feature extraction framework for motion defuzzification is designed using deep convolutional neural networks, and enhanced multi-scale residual blocks and multi-scale feature extraction modules are utilized to capture rich local and global features. Secondly, the efficient channel attention module is added to strengthen the weights of effective features and suppress invalid features by modeling the correlations between channels. In addition, training stability is achieved through the use of the WGAN-div loss function, leading to the generation of higher quality samples. Finally, the proposed algorithm is evaluated through qualitative and quantitative comparisons with several recent methods on both the GOPRO public dataset and a self-constructed QR code dataset, respectively. The experimental results demonstrate that, compared to the other methods, the proposed algorithm has shown significant improvements in both processing time and recognition accuracy when dealing with the task of severe motion-blurred QR code recognition.
Pattern of Virtual Consultations in the Kingdom of Saudi Arabia: An Epidemiological Nationwide Study
Authors: AlOmar Reem S. , AlHarbi Muaddi , Alotaibi Nijr S. , AlShamlan Nouf A. , Al-Shammari Malak A , AlThumairi Arwa A. , AlSubaie Mona , Alshahrani Mohammed A. , AlAbdulaali Mohammad K.
Published: April 2024

Background

In the Kingdom of Saudi Arabia (KSA), little is known about the adoption of virtual consultations (VCs), with most studies being survey-based leading to varying results. This study aims to utilise secondary collected data on the use of both kinds of VCs currently available, and to epidemiologically describe the adoption of these consultations.

Methods

This retrospective study analysed data provided by the Ministry of Health between January 1st 2021 and June 30th 2022. For both the home-based and the hospital-based consultations, variables included the age and sex of patients, date of consultation, duration in minutes, closure status for the appointment and the governorate in which the patient is residing. A heat map was drawn to present patterns of utilisation across the country.

Results

The total number of VCs for both types were 1,008,228. For both types, females were higher adopters (54.73%). Of the total number of consultations, 751,156 were hospital-based. Of these consultations, family medicine consultations were the most common (20.42%), followed by internal medicine. Maternity follow-up clinics were higher in home-based clinics. The proportion of patient no-shows was high overall (48.30%). Utilisation was high in urban governorates, and low in rural ones.

Conclusion

Findings have several implications on health policy. It provides further evidence of the importance of family medicine, where it was the most common speciality even in hospital-based settings. The high variability in the adoption of consultations across rural and urban areas as well as the extremely high number of patient-no-shows warrants further investigation.
Risk of sleep disorders in patients with pneumoconiosis: a retrospective cohort study
Authors: Lin Yen-Sung , Shen Te-Chun , Lin Cheng-Li , Tu Chih-Yen , Hsia Te-Chun , Hsu Wu-Huei , Cho Der-Yang
Published: April 2024

Background

Pneumoconiosis is associated with pulmonary and cardiovascular diseases; however, the link between pneumoconiosis and sleep disorders is not well understood. This study aimed to investigate the connection between pneumoconiosis and subsequent risk of sleep disorders.

Methods

This population-based retrospective cohort study used data from the National Health Insurance database in Taiwan. The pneumoconiosis cohort consisted of 13,329 patients newly diagnosed between 2000 and 2015. The comparison group included 53,316 age-, sex-, and diagnosis date-matched individuals without pneumoconiosis. The development of sleep disorders was monitored until the end of 2018. Cox proportional hazard regression models were used for risk assessment.

Results

The incidence of sleep disorders was 1.31 times higher in the pneumoconiosis cohort than in the comparison cohort (22.8 vs. 16.2 per 1000 person-years). After controlling for age, sex, comorbidity, and medication, the adjusted hazard ratio (aHR) was 1.24 (95% confidence interval [CI] = 1.17–1.32). Stratified analyses by age group, sex, and comorbidity status showed significant associations between pneumoconiosis and sleep disorders (aHRs, 1.19–1.64). In addition, patients with pneumoconiosis had a significantly increased risk of developing sleep apnea (aHR = 1.71, 95% CI = 1.31–2.22).

Conclusion

This study demonstrates that patients with pneumoconiosis are at a higher risk of developing sleep disorders and sleep apnea. Healthcare professionals should pay close attention to sleep quality and disturbances in patients with pneumoconiosis.
Evaluating the Usefulness of Counterfactual Explanations from Bayesian Networks
Authors: Butz Raphaela , Hommersom Arjen , Schulz Renée , van Ditmarsch Hans
Published: April 2024

Bayesian networks are commonly used for learning with uncertainty and incorporating expert knowledge. However, they are hard to interpret, especially when the network structure is complex. Methods used to explain Bayesian networks operate under certain assumptions about what constitutes the best explanation, without actually verifying these assumptions. One such common assumption is that a shorter length of the causal chain of one variable to another enhances its explanatory strength. Counterfactual explanations gained popularity in artificial intelligence over the last years. It is well-known that it is possible to generate counterfactuals from causal Bayesian networks, but there is no indication which of them are useful for explanatory purposes. In this paper, we examine how to apply findings from psychology to search for counterfactuals that are perceived as more useful explanations for the end user. For this purpose, we have conducted a questionnaire to test whether counterfactuals that change an actionable cause are considered more useful than counterfactuals that change a direct cause. The results of the questionnaire indicate that actionable counterfactuals are preferred regardless of being the direct cause or having a longer causal chain.
Towards a holistic view of bias in machine learning: bridging algorithmic fairness and imbalanced learning
Authors: Dablain Damien , Krawczyk Bartosz , Chawla Nitesh
Published: April 2024

Machine learning (ML) is playing an increasingly important role in rendering decisions that affect a broad range of groups in society. This posits the requirement of algorithmic fairness, which holds that automated decisions should be equitable with respect to protected features (e.g., gender, race). Training datasets can contain both class imbalance and protected feature bias. We postulate that, to be effective, both class and protected feature bias should be reduced—which allows for an increase in model accuracy and fairness. Our method, Fair OverSampling (FOS), uses SMOTE (Chawla in J Artif Intell Res 16:321–357, 2002) to reduce class imbalance and feature blurring to enhance group fairness. Because we view bias in imbalanced learning and algorithmic fairness differently, we do not attempt to balance classes and features; instead, we seek to de-bias features and balance the number of class instances. FOS restores numerical class balance through the creation of synthetic minority class instances and causes a classifier to pay less attention to protected features. Therefore, it reduces bias for both classes and protected features. Additionally, we take a step toward bridging the gap between fairness and imbalanced learning with a new metric, Fair Utility, that measures model effectiveness with respect to accuracy and fairness. Our source code and data are publicly available at https://github.com/dd1github/Fair-Over-Sampling.
Babylonian Jews and Sasanian Imperialism in Late Antiquity
Authors: Gross Simcha
Published: April 2024

From the image offered by the Babylonian Talmud, Jewish elites were deeply embedded within the Sasanian Empire (224-651 CE). The Talmud is replete with stories and discussions that feature Sasanian kings, Zoroastrian magi, fire temples, imperial administrators, Sasanian laws, Persian customs, and more quotidian details of Jewish life. Yet, in the scholarly literature on the Babylonian Talmud and the Jews of Babylonia , the Sasanian Empire has served as a backdrop to a decidedly parochial Jewish story, having little if any direct impact on Babylonian Jewish life and especially the rabbis. Babylonian Jews and Sasanian Imperialism in Late Antiquity advances a radically different understanding of Babylonian Jewish history and Sasanian rule. Building upon recent scholarship, Simcha Gross portrays a more immanent model of Sasanian rule, within and against which Jews invariably positioned and defined themselves. Babylonian Jews realized their traditions, teachings, and social position within the political, social, religious, and cultural conditions generated by Sasanian rule.
Care, Ecology, and the Crisis of Eco-social Reproduction: Politicizing More-than-Human Care
Authors: Silberzahn Léna
Published: April 2024

While the ethics of care has considered the possibility that caring occurs for the environment, it often remains silent about the caregiving that humans receive from the environment. This essay suggests that ecological justice requires humans to consider themselves not only as ecological caregivers, but also as care receivers from more-than-human earth dwellers. The argument is built by first accounting for the diverse forms of care that humans receive from other-than-humans. The focus then turns to eco-feminist and eco-Marxist thought to denaturalize this care, highlighting how capitalist economies put other-than-humans to work and appropriate their efforts to maintain the world. The fact that they cannot demand a salary and that the commodification of life increases its depletion leads to an examination of how the conceptual recognition of more-than-human care can be translated politically. The article sketches how the political tensions at work in practices and conceptions of care outlined by feminist and indigenous thought could allow to engage more critically with environmental issues, notably by blending environmental humanities’ emphasis on affective dispositions and attachments towards other-than-humans, with materialist ambitions to highlight exploitation and invisible labor.
Bifurcation of equilibrium positions for ellipsoidal particles in inertial shear flows between two walls
Authors: Lauricella Giuseppe , Naderi Mohammad Moein , Zhou Jian , Papautsky Ian , Peng Zhangli
Published: April 2024

We conducted a systematic numerical investigation of spherical, prolate and oblate particles in an inertial shear flow between two parallel walls, using smoothed particle hydrodynamics (SPH). It was previously shown that above a critical Reynolds number, spherical particles experience a supercritical pitchfork bifurcation of the equilibrium position in shear flow between two parallel walls, namely that the central equilibrium position becomes unstable, leading to the emergence of two new off-centre stable positions (Fox et al., J. Fluid Mech., vol. 915, 2021). This phenomenon was unexpected given the symmetry of the system. In addition to confirming this finding, we found, surprisingly, that ellipsoidal particles can also return to the centre position from the off-centre positions when the particle Reynolds number is further increased, while spherical particles become unstable under this increased Reynolds number. By utilizing both SPH and the finite element method for flow visualization, we explained the underlining mechanism of this reverse of bifurcation by altered streamwise vorticity and symmetry breaking of pressure. Furthermore, we expanded our investigation to include asymmetric particles, a novel aspect that had not been previously modelled, and we observed similar trends in particle dynamics for both symmetric and asymmetric ellipsoidal particles. While further validation through laboratory experiments is necessary, our research paves the road for development of new focusing and separation methods for shaped particles.
Optimal wall shapes and flows for steady planar convection
Authors: Alben Silas
Published: April 2024

We compute steady planar incompressible flows and wall shapes that maximize the rate of heat transfer (

$Nu$

) between hot and cold walls, for a given rate of viscous dissipation by the flow (

$Pe^2$

), with no-slip boundary conditions at the walls. In the case of no flow, we show theoretically that the optimal walls are flat and horizontal, at the minimum separation distance. We use a decoupled approximation to show that flat walls remain optimal up to a critical non-zero flow magnitude. Beyond this value, our computed optimal flows and wall shapes converge to a set of forms that are invariant except for a

$Pe^{-1/3}$

scaling of horizontal lengths. The corresponding rate of heat transfer

$Nu \sim Pe^{2/3}$

. We show that these scalings result from flows at the interface between the diffusion-dominated and convection-dominated regimes. We also show that the separation distance of the walls remains at its minimum value at large

$Pe$

.
How the Public Became the Caller: The Emergence of Reactive Policing, 1880–1970
Authors: Gillooly Jessica W. , Thacher David
Published: April 2024

Why is the police role so broad in the United States today? Carceral state scholars have investigated how and why policymakers have treated so many social problems as policing problems, but they have not yet recognized the degree to which the call-for-service system has marginalized political control over police strategy. This Article traces the historical sources of this arrangement through extensive archival research into its evolution. We find that over the course of the twentieth century, the rise of new communications technologies gradually shifted the power to decide which problems are proper subjects of police attention to private individuals, eventually channeling their demands through centralized call centers that had been stripped of the authority and contextual knowledge needed to govern them in a meaningful way. That process fundamentally altered the character of public oversight over policing, elevating a distinctive set of individual interests as largely unchallenged determinants of the kinds of situations that are policeable. By illustrating how sociotechnical change unintentionally reallocated the authority to define the scope of an important institution’s mandate, this case sheds new light on the factors that shape the police role and the role the public plays in defining it.
ADDRESSING THE INTENSITY OF CHANGES IN THE PREHISTORIC POPULATION DYNAMICS: POPULATION GROWTH RATE ESTIMATIONS IN THE CENTRAL BALKANS EARLY NEOLITHIC
Authors: Blagojević Tamara , Porčić Marko , Stefanović Sofija
Published: April 2024

The intensity of changes in the population dynamics of the Early Neolithic (ca. 6250–5300 cal BC) communities in the Central Balkans was addressed by estimating the growth rate values. The Bayesian approach (Crema and Shoda 2021) of estimating intrinsic growth rates by fitting different models of population growth was applied to radiocarbon dates from the Early Neolithic sites in Serbia. We explored two possible episodes of population growth based on the results of the population dynamics reconstruction using the summed calibrated radiocarbon probability distributions (SPD) method. The results have shown that, within the first episode of growth, the intrinsic growth rate mean values are higher than the estimated continental average (between 1% and 2%). The results indicate a sudden and fast rise in population size, possibly due to the influx of the new population settling in the region at the beginning of the Neolithic. Lower values for the second episode could indicate more gradual population growth due to the mechanisms associated with the Neolithic Demographic Transition and the rise in fertility.
Sibelian Formal Principles in the First Movement of Malcolm Arnold’s Fifth Symphony
Authors: ROSS RYAN
Published: April 2024

Malcolm Arnold’s symphonies have persistently divided critical opinion because of their problematic relationship with traditional genre expectations. This is especially the case in works that eschew sonata-style tonal conflicts and formal markers in favour of theme- and timbre-driven processes. In these respects, Sibelius, rather than members of the Austro-German symphonic tradition, was an important model for Arnold’s individual approach to symphonic composition. This article applies four formal principles (content-based forms, teleological genesis, rotational form and klang meditation), which James Hepokoski has explicitly identified with Sibelius’s later symphonic style, to the first movement of Arnold’s Fifth – one of his most admired and yet most unconventional symphonic structures. The resulting analysis shows a complex and yet accessible movement that generates its own unique tension and dramatic interest. Far from being the feeble work of a symphonic lightweight, it is an impressively realized landmark of the genre in the late twentieth century.
Structure-function coupling and hierarchy-specific antidepressant response in major depressive disorder
Authors: Wang Xinyi , Xue Li , Hua Lingling , Shao Junneng , Yan Rui , Yao Zhijian , Lu Qing
Published: April 2024

Background

Extensive research has explored altered structural and functional networks in major depressive disorder (MDD). However, studies examining the relationships between structure and function yielded heterogeneous and inconclusive results. Recent work has suggested that the structure-function relationship is not uniform throughout the brain but varies across different levels of functional hierarchy. This study aims to investigate changes in structure-function couplings (SFC) and their relevance to antidepressant response in MDD from a functional hierarchical perspective.

Methods

We compared regional SFC between individuals with MDD (n = 258) and healthy controls (HC, n = 99) using resting-state functional magnetic resonance imaging and diffusion tensor imaging. We also compared antidepressant non-responders (n = 55) and responders (n = 68, defined by a reduction in depressive severity of >50%). To evaluate variations in altered and response-associated SFC across the functional hierarchy, we ranked significantly different regions by their principal gradient values and assessed patterns of increase or decrease along the gradient axis. The principal gradient value, calculated from 219 healthy individuals in the Human Connectome Project, represents a region's position along the principal gradient axis.

Results

Compared to HC, MDD patients exhibited increased SFC in unimodal regions (lower principal gradient) and decreased SFC in transmodal regions (higher principal gradient) (p < 0.001). Responders primarily had higher SFC in unimodal regions and lower SFC in attentional networks (median principal gradient) (p < 0.001).

Conclusions

Our findings reveal opposing SFC alterations in low-level unimodal and high-level transmodal networks, underscoring spatial variability in MDD pathology. Moreover, hierarchy-specific antidepressant effects provide valuable insights into predicting treatment outcomes.
Efficacy of catheter ablation in ganglionated plexus for malignant vasovagal syncope children
Authors: Li Hongxia , Shao Wei , Yu Xia , Gao Lu , Yuan Yue
Published: April 2024

Aim:

Malignant vasovagal syncope in children seriously affects their physical and mental health. Our study aimed to explore the efficacy of catheter ablation in ganglionated plexus with malignant vasovagal syncope children.

Conclusion:

Catheter ablation of ganglionated plexus was safe and effective in children with malignant vasovagal syncope and can be used as a treatment option for these children.

Methods:

A total of 20 children diagnosed with malignant vasovagal syncope were enrolled in Beijing Children’s Hospital, affiliated with Capital Medical University. All underwent catheter ablation treatment of ganglionated plexus. Ganglionated plexuses of the left atrium were identified by high-frequency stimulation and/or anatomic landmarks being targeted by radiofrequency catheter ablation. The efficacy of the treatment was evaluated by comparing the remission rate of post-operative syncopal symptoms and the rate of negative head-up tilt results. Safety and adverse events were evaluated.

Results:

After follow-up for 2.5 (0.6–5) years, the syncope symptom scores were decreased significantly compared with before treatment [3 (2–4) versus 5 (3–8) scores, P < 0.01]. Eighty-five per cent (17/20) children no longer experienced syncope, whilst 80% (16/20) children showed negative head-up tilt test after treatment. No adverse effects such as cardiac arrhythmia occurred in the children.
Monetary policy in advanced and emerging economies
Authors: Serletis Apostolos , Dery Cosmas
Published: April 2024

We are motivated by central bank responses to the rise in inflation in the aftermath of the coronavirus pandemic and investigate monetary policy behavior in advanced and emerging economies. We speak to the debate on whether the conduct of monetary policy in emerging economies is fundamentally different from that in advanced economies. We also address the issue of whether the common practice of using market rates (instead of policy rates) to proxy for the stance of monetary policy leads to different conclusions regarding the cyclicality of monetary policy in emerging economies. Using time series data for the G7 and EM7 countries, we show that the conventional wisdom that monetary policy in emerging economies is different from monetary policy in advanced economies still holds.
Response to Critics: Kant’s Theory of Labour
Authors: Pascoe Jordan
Published: April 2024

Elvira Basevich, Martin Sticker, and Helga Varden offered generative criticism of my monograph, Kant’s Theory of Labour. In this response, I explore how the resources they offer for thinking about gender, labour, and the state’s responsibility to ensure the material conditions of freedom can deepen both our attentiveness to patterns of systemic injustice in Kant’s political philosophy, and the resources Kant offers for addressing contemporary patterns of intersectional and material injustice.
Inferring the Paleo‐Location of Proto‐Arc Magmas During Subduction Infancy in the Izu‐Bonin‐Mariana
Authors: Ribeiro Julia M. , Gerya Taras
Published: April 2024

Subduction zones are one of the principal drivers of the modern‐day plate tectonics, but the processes that develop as incipient subduction zones mature are yet to be understood. Finding modern analogs for different stages of subduction infancy remains an outstanding challenge to answer questions on how and when an oceanic subduction zone reaches a quasi‐steady state to become long‐lived. Here, we compare the southern Mariana intra‐oceanic arc, in which near‐trench spreading and infant arc magmatism developed ∼3–4 Myr ago, with the Izu‐Bonin‐Mariana (IBM) proto‐arc magmas that formed during subduction infancy ∼52 Myr ago. Building upon this comparison, we propose that the Southern Mariana may be considered as a modern analog to subduction infancy. The similarities between the Southern Mariana arc magmas and the IBM Eocene proto‐arc magmas suggest that the IBM proto‐arc crust might have formed within 80–90 km from the paleo‐trench (slab at < 90 km paleo‐depth), while the Eocene infant arc was likely located at ∼100 km from the paleo‐trench (∼100–125 km slab paleo‐depth). We use our constraints further to propose a new conceptual model of subduction evolution for IBM. In this model, development of the subduction channel during arc infancy facilitated downward slab penetration and intensified corner flow in the sub‐arc asthenosphere of the mantle wedge. As such, cooling and serpentinization of the fore‐arc mantle might be considered as the principal drivers of subduction maturation and stabilization over the IBM lifetime.
Signatures of Dipolarizing Flux Bundles in the Nightside Auroral Zone
Authors: Engebretson Mark J. , Gaffaney Sean A. , Ochoa Jesus A. , Runov Andrei , Weygand James M. , Nishimura Yukitoshi , Hartinger Michael D. , Pilipenko Vyacheslav A. , Moldwin Mark B. , Connors Martin G. , Mann Ian R. , Xu Zhonghua , Rodriguez Juan V.
Published: April 2024

Dipolarizing flux bundles (DFBs) have been suggested to transport energy and momentum from regions of reconnection in the magnetotail to the high latitude ionosphere, where they can generate localized ionospheric currents that can produce large nighttime geomagnetic disturbances (GMDs). In this study we identified DFBs observed in the midnight sector from ∼7 to ∼10 RE by THEMIS A, D, and E during days in 2015–2017 whose northern hemisphere magnetic footpoints mapped to regions near Hudson Bay, Canada, and have compared them to isolated GMDs observed by ground magnetometers. We found 6 days during which one or more of these DFBs coincided to within ±3 min with ≥6 nT/s GMDs observed by latitudinally closely spaced ground‐based magnetometers located near those footpoints. Spherical elementary current systems (SECS) maps and all‐sky imager data provided further characterization of two events, showing short‐lived localized intense upward currents, auroral intensifications and/or streamers, and vortical perturbations of a westward electrojet. On all but one of these days the coincident DFB—GMD pairs occurred during intervals of high‐speed solar wind streams but low values of SYM/H. The observations reported here indicate that isolated DFBs generated under these conditions influence only limited spatial regions nearer Earth. In some events, in which the DFBs were observed closer to Earth and with lower Earthward velocities, the GMDs occurred slightly earlier than the DFBs, suggesting that braking had begun before the time of the DFB observation.
Banding in the Margins of Basaltic Dykes Indicates Pulsatory Propagation During Emplacement
Authors: Allgood C. , Llewellin E. W. , Humphreys M. C. S. , Mathias S. A. , Brown R. J. , Vye‐Brown C.
Published: April 2024

Basaltic fissure eruptions, which are the most common type of eruption on Earth, are fed by dykes which mediate magma transport through the crust. Dyke propagation processes are important because they determine the geometry of the transport pathway and the nature of any geophysical signals associated with magma ascent. Here, we investigate small‐scale (mm–cm wide) banding features at the margins of dykes in the Teno Massif (Tenerife, Spain) and the Columbia River Basalt Province (CRBP) (USA). Similar marginal bands have been reported for dykes in numerous localities around the world. Dyke margins record valuable information about propagation because they are the first material to solidify against the host rock at the propagating dyke tip. We find that the marginal bands are defined by cyclic variations in phenocryst concentration and vesicularity, and we infer that these cyclic variations in texture are a product of cyclic variations in magma flow rates and pressures within the dyke tip. This indicates that dyke emplacement occurs in pulses, with propagation repeatedly hindered by the rapid cooling and solidification of magma in the narrow dyke tip. Using a 1D conduction model, we estimate the time taken for each band to cool and solidify, which provides a timescale of several minutes to tens of minutes for the pulses. The occurrence of similar bands in various volcanic settings suggests that pulsatory propagation is a common, if not ubiquitous, process associated with dyke emplacement.
Fetch‐Limited, Strongly Forced Wind Waves in Waters With Frazil and Grease Ice – Spectral Modeling and Satellite Observations in an Antarctic Coastal Polynya
Authors: Herman Agnieszka , Bradtke Katarzyna
Published: April 2024

Sea ice–wave interactions have been widely studied in the marginal ice zone, at relatively low wind speeds and wave frequencies. Here, we focus on very different conditions typical of coastal polynyas: extremely high wind speeds and locally generated, short, steep waves. We overview available parameterizations of relevant physical processes (nonlinear wave–wave interactions, energy input by wind, whitecapping and ice‐related dissipation) and discuss modifications necessary to adjust them to polynya conditions. We use satellite‐derived data and spectral modeling to analyze waves in 10 polynya events in the Terra Nova Bay, Antarctica. We estimate the wind‐input reduction factor over frazil/grease ice in the wave‐energy balance equation at 0.56. By calibrating the model to satellite observations we show that exact treatment of quadruplet wave–wave interactions (as opposed to the default Discrete Interaction Approximation) is necessary to fit the model to data, and that the power n > 4 in the sea‐ice source term Sice ∼ fn (where f denotes wave frequency) is required to reproduce the strong attenuation of high‐frequency waves observed for frazil streaks. We use a very‐high resolution satellite image of a fragment of one of the polynyas to determine whitecap fraction. We show that there are more than twofold differences in whitecap fraction over ice‐free and ice‐covered regions, and that the model produces realistic whitecap fractions without any tuning of the whitecapping source term. Finally, we estimate the polynya‐area‐integrated wind input, energy dissipation due to whitecapping, and whitecap fraction to be on average below 25%, 10% and 30%, respectively, of the corresponding open‐water values.
HbA1c or fructosamine on evaluating glucose intolerance in children with beta- thalassemia
Authors: Mahmoud Asmaa A. , El-Hawy Mahmoud A. , Allam Esraa T. , Salem Ahmed H. , Abo Hola Ahmed S.
Published: April 2024

Background

Beta-thalassemia major (β-TM) patients are more likely to experience blood glucose intolerance and to date; the blood markers that could evaluate this are debatable. So, this study aimed to assess the roles of glycated hemoglobin A1c (HbA1c) and fructosamine in evaluating glucose intolerance in children with β-TM and figuring out role of insulin resistance in these patients.

Methods

One hundred children diagnosed with β-TM and 100 age and sex-matched controls were enrolled. Fasting plasma glucose (FPG), 2-h post-prandial blood glucose (2-h PG), HbA1c, fructosamine, fasting insulin level (FINS), insulin resistance index (HOMA-IR), and insulin sensitivity index (HOMA-IS) were evaluated.

Results

FPG and 2-h PG revealed glucose intolerance in 51 patients (51%), 19 of them had diabetes mellitus. HbA1c, fructosamine, FINS, and HOMA-IR showed a high statistically significant increase in patients compared to controls, (P < 0.001). Results revealed fructosamine was more specific in detecting prediabetes state and more sensitive in identifying diabetes mellitus in our patients when compared to HbA1c.

Conclusions

Despite controversies on HbA1c in children with β-TM, it is still valuable in glucose intolerance detection. Fructosamine showed more sensitivity and specificity. Furthermore, insulin resistance was prevalent in children with β-TM highlighting the necessity of regular glycemic state evaluation.

Impact

Glucose intolerance is a common complication in beta thalassemia patients.

Conflicting data was reported about the role of HbA1c and fructosamine in evaluating glucose intolerance in thalassemic patients.

Fructosamine does not yet have a threshold that may be used to distinguish between patients who have diabetes mellitus and those who do not.

Fructosamine was more specific in detecting blood glucose intolerance compared to HbA1c and was more sensitive for diagnosing diabetes mellitus.

Insulin resistance was common in patients with beta-thalassemia and often present before the onset of overt diabetes.
Neuron enriched extracellular vesicles’ MicroRNA expression profiles as a marker of early life alcohol consumption
Authors: Yakovlev Vasily , Lapato Dana M. , Rana Pratip , Ghosh Preetam , Frye Rebekah , Roberson-Nay Roxann
Published: April 2024

Alcohol consumption may impact and shape brain development through perturbed biological pathways and impaired molecular functions. We investigated the relationship between alcohol consumption rates and neuron-enriched extracellular vesicles’ (EVs’) microRNA (miRNA) expression to better understand the impact of alcohol use on early life brain biology. Neuron-enriched EVs’ miRNA expression was measured from plasma samples collected from young people using a commercially available microarray platform while alcohol consumption was measured using the Alcohol Use Disorders Identification Test. Linear regression and network analyses were used to identify significantly differentially expressed miRNAs and to characterize the implicated biological pathways, respectively. Compared to alcohol naïve controls, young people reporting high alcohol consumption exhibited significantly higher expression of three neuron-enriched EVs’ miRNAs including miR-30a-5p, miR-194-5p, and miR-339-3p, although only miR-30a-5p and miR-194-5p survived multiple test correction. The miRNA-miRNA interaction network inferred by a network inference algorithm did not detect any differentially expressed miRNAs with a high cutoff on edge scores. However, when the cutoff of the algorithm was reduced, five miRNAs were identified as interacting with miR-194-5p and miR-30a-5p. These seven miRNAs were associated with 25 biological functions; miR-194-5p was the most highly connected node and was highly correlated with the other miRNAs in this cluster. Our observed association between neuron-enriched EVs’ miRNAs and alcohol consumption concurs with results from experimental animal models of alcohol use and suggests that high rates of alcohol consumption during the adolescent/young adult years may impact brain functioning and development by modulating miRNA expression.
Utilization of antidepressants, anxiolytics, and hypnotics during the COVID-19 pandemic
Authors: Tiger Mikael , Castelpietra Giulio , Wesselhoeft Rikke , Lundberg Johan , Reutfors Johan
Published: April 2024

Since the onset of the COVID-19 pandemic, there have been concerns over the mental health impact of COVID-19. This is a review of the utilization of antidepressants, anxiolytics, and hypnotics since the COVID-19 pandemic was declared on March the 11th 2020. A number of reports so far have been based on large prescription databases for administrative use at the national or regional level, but mainly in high-income countries. We found studies reporting increased prescription rates of antidepressants, anxiolytics, and hypnotics during March 2020, which has been interpreted as hoarding of such medications. In the following months, most studies of antidepressant prescription rates did not display a clear pattern of change compared with prepandemic trends. In later phases of the pandemic small increases in utilization of antidepressants, with higher than predicted prescription rates, have been the most consistent finding, especially in youth. In most high-income countries, there were increasing trends in utilization of antidepressants also before 2020, which needs to be considered when estimating utilization during the pandemic, whereas for anxiolytics and hypnotics, the prepandemic patterns of prescriptions were more varying. Overall, after March 2020 we could not find any distinct changes in the utilization of anxiolytics and hypnotics during the COVID-19 pandemic. Most studies did not contain information about the prevalence of indicated psychiatric disorders in the studied populations. More studies are needed about the long-term effects of COVID-19, particularly regarding utilization of antidepressants. Research relating antidepressant utilization with the prevalence of major depression and anxiety disorders would promote a better understanding of how well antidepressant prescription rates reflect the needs of the population.
Ovarian tumor cell-derived JAGGED2 promotes omental metastasis through stimulating the Notch signaling pathway in the mesothelial cells
Authors: Islam Syed S. , Al-Mohanna Falah H. , Yousef Iman M. , Al-Badawi Ismail A. , Aboussekhra Abdelilah
Published: April 2024

The primary site of metastasis for epithelial ovarian cancer (EOC) is the peritoneum, and it occurs through a multistep process that begins with adhesive contacts between cancer cells and mesothelial cells. Despite evidence that Notch signaling has a role in ovarian cancer, it is unclear how exactly it contributes to ovarian cancer omental metastasis, as well as the cellular dynamics and intrinsic pathways that drive this tropism. Here we show that tumor cells produced the Notch ligand Jagged2 is a clinically and functionally critical mediator of ovarian cancer omental metastasis by activating the Notch signaling in single-layered omental mesothelial cells. In turn, Jagged2 promotes tumor growth and therapeutic resistance by stimulating IL-6 release from mesothelial cells. Additionally, Jagged2 is a potent downstream mediator of the omental metastasis cytokine TGF-β that is released during omental destruction. Importantly, therapeutic inhibition of Jagged2-mediated omental metastasis was significantly improved by directly disrupting the Notch pathway in omental mesothelial cells. These findings highlight the key role of Jagged2 to the functional interplay between the TGF-β and the Notch signaling pathways during the metastatic process of ovarian cancer cells to the omentum and identify the Notch signaling molecule as a precision therapeutic target for ovarian cancer metastasis.
The GFPT2-O-GlcNAcylation-YBX1 axis promotes IL-18 secretion to regulate the tumor immune microenvironment in pancreatic cancer
Authors: Zhang Hui-Ru , Li Tian-Jiao , Yu Xian-Jun , Liu Chen , Wu Wei-Ding , Ye Long-Yun , Jin Kai-Zhou
Published: April 2024

The immunosuppressive microenvironment caused by several intrinsic and extrinsic mechanism has brought great challenges to the immunotherapy of pancreatic cancer. We identified GFPT2, the key enzyme in hexosamine biosynthesis pathway (HBP), as an immune-related prognostic gene in pancreatic cancer using transcriptome sequencing and further confirmed that GFPT2 promoted macrophage M2 polarization and malignant phenotype of pancreatic cancer. HBP is a glucose metabolism pathway leading to the generation of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), which is further utilized for protein O-GlcNAcylation. We confirmed GFPT2-mediated O-GlcNAcylation played an important role in regulating immune microenvironment. Through cellular proteomics, we identified IL-18 as a key downstream of GFPT2 in regulating the immune microenvironment. Through CO-IP and protein mass spectrum, we confirmed that YBX1 was O-GlcNAcylated and nuclear translocated by GFPT2-mediated O-GlcNAcylation. Then, YBX1 functioned as a transcription factor to promote IL-18 transcription. Our study elucidated the relationship between the metabolic pathway of HBP in cancer cells and the immune microenvironment, which might provide some insights into the combination therapy of HBP vulnerability and immunotherapy in pancreatic cancer.
POLQ inhibition attenuates the stemness and ferroptosis resistance in gastric cancer cells via downregulation of dihydroorotate dehydrogenase
Authors: Peng Yanmei , Zheng Wenbo , Chen Yuehong , Lei Xuetao , Yang Zhijing , Yang Yuxuan , Liang Weiqi , Sun Kai , Li Guoxin , Yu Jiang
Published: April 2024

Gastric cancer (GC) contains subpopulations of cancer stem cells (CSCs), which are described as the main contributors in tumor initiation and metastasis. It is necessary to clarify the molecular mechanism underlying CSCs phenotype and develop novel biomarkers and therapeutic targets for gastric cancer. Here, we show that POLQ positively regulates stem cell-like characteristics of gastric cancer cells, knockdown of POLQ suppressed the stemness of GC cells in vitro and in vivo. Further mechanistic studies revealed that POLQ knockdown could downregulate the expression of dihydroorotate dehydrogenase (DHODH). DHODH overexpression rescued the reduced stemness resulted by POLQ knockdown. Furthermore, we found that POLQ expression correlated with resistance to ferroptosis, and POLQ inhibition renders gastric cancer cells more vulnerable to ferroptosis. Further investigation revealed that POLQ regulated DHODH expression via the transcription factors E2F4, thereby regulating ferroptosis resistance and stemness of gastric cancer cells. Given the importance of POLQ in stemness and ferroptosis resistance of GC, we further evaluated the therapeutic potential of POLQ inhibitor novobiocin, the results show that novobiocin attenuates the stemness of GC cells and increased ferroptosis sensitivity. Moreover, the combination of POLQ inhibitor and ferroptosis inducer synergistically suppressed MGC-803 xenograft tumor growth and diminished metastasis. Our results identify a POLQ-mediated stemness and ferroptosis defense mechanism and provide a new therapeutic strategy for gastric cancer.
Genetic structure and landscape effects on gene flow in the Neotropical lizard Norops brasiliensis (Squamata: Dactyloidae)
Authors: Fonseca Emanuel M. , Pope Nathaniel S. , Peterman William E. , Werneck Fernanda P. , Colli Guarino R. , Carstens Bryan C.
Published: April 2024

One key research goal of evolutionary biology is to understand the origin and maintenance of genetic variation. In the Cerrado, the South American savanna located primarily in the Central Brazilian Plateau, many hypotheses have been proposed to explain how landscape features (e.g., geographic distance, river barriers, topographic compartmentalization, and historical climatic fluctuations) have promoted genetic structure by mediating gene flow. Here, we asked whether these landscape features have influenced the genetic structure and differentiation in the lizard species Norops brasiliensis (Squamata: Dactyloidae). To achieve our goal, we used a genetic clustering analysis and estimate an effective migration surface to assess genetic structure in the focal species. Optimized isolation-by-resistance models and a simulation-based approach combined with machine learning (convolutional neural network; CNN) were then used to infer current and historical effects on population genetic structure through 12 unique landscape models. We recovered five geographically distributed populations that are separated by regions of lower-than-expected gene flow. The results of the CNN showed that geographic distance is the sole predictor of genetic variation in N. brasiliensis, and that slope, rivers, and historical climate had no discernible influence on gene flow. Our novel CNN approach was accurate (89.5%) in differentiating each landscape model. CNN and other machine learning approaches are still largely unexplored in landscape genetics studies, representing promising avenues for future research with increasingly accessible genomic datasets.
Increase in concerns about climate change following climate strikes and civil disobedience in Germany
Authors: Brehm Johannes , Gruhl Henri
Published: April 2024

Climate movements have gained momentum in recent years, aiming to create public awareness of the consequences of climate change through salient climate protests. This paper investigates whether concerns about climate change increase following demonstrative protests and confrontational acts of civil disobedience. Leveraging individual-level survey panel data from Germany, we exploit exogenous variations in the timing of climate protests relative to survey interview dates to compare climate change concerns in the days before and after a protest (N = 24,535). Following climate protests, we find increases in concerns about climate change by, on average, 1.2 percentage points. Further, we find no statistically significant evidence that concerns of any subpopulation decreased after climate protests. Lastly, the increase in concerns following protests is highest when concern levels before the protests are low.