bluuebunny/crossref_metadata_2025 huggingface dataset:
Protocol for Testing Flexural Strength, Flexural Modulus, and Fatigue Failure of Cementitiously Stabilized Materials Using Third-Point Flexural Beam Tests
Authors: Mandal Tirupan , Tinjum James M. , Gokce Ahmet , Edil Tuncer B.
Published: June 2015

In this study, a testing protocol was developed to measure the flexural strength, flexural modulus, and fatigue failure of cementitiously stabilized materials (CSMs) for both lightly and heavily stabilized soils. Four soils (sand, gravel, silt, and clay) and four binders (cement, lime, class C fly ash, and class F fly ash) were used in this study. Beam specimens (100 mm high by 100 mm wide by 400 mm long) were prepared and tested using third-point flexural beam tests. A fatigue distress model was developed, and the data from this study was validated using other existing stress-based fatigue models. Results indicated that the testing protocol could be used to determine the flexural strength, flexural modulus, and fatigue behavior of the cementitiously stabilized layers (CSL). A stress-based fatigue performance model was a good fit for the whole range of CSMs, which is needed to predict the fatigue performance of CSL in the field and to determine the fatigue life of the CSLs.
In-Flight Simulation of the Excavation of Foundation Pit in Centrifuge Model Tests
Authors: Zhang Ga , Yan Guanchen
Published: June 2015

It is of great importance to simulate the excavation of foundation pits in centrifuge model tests. A new device was designed with new principles based on the understanding of the stress field in the soil base before and after excavation. A loading system was used to replace the excavated soil so that the appropriate self-weight stress state could be achieved with an increase of centrifugal acceleration before excavation. The compensation unit and the confining structure were simultaneously removed using the loading unit to simulate the excavation with accuracy. The device was made using a series of new structures for a high degree of automation and good accuracy in simulating the excavation of foundation pits. This device can be used to test a wide range of pit foundations and supporting structures. All of the components of the device were carefully designed to minimize their size and mass with a good control on the deformation of themselves. The device was confirmed to be effective in simulating the excavation of foundation pits at the 50-g level by a series of centrifuge model tests. The true paths of the stress and deformation of the foundation pit could be reasonably simulated in the centrifuge model tests, which cannot be captured by the traditional method in which the excavation was conducted previously at the 1-g level. The traditional method underestimates the earth pressures and the deformation of the soil due to the excavation of the foundation pit according to the comparison tests.
One Mosaic, Many Voices: A Reflection on the Baltimore '68 Mosaic Monument
Authors: Ralls Christina
Published: June 2015

Communal storytelling within a group of diverse individuals, linked by common experiences, results in a more inclusive, encompassing, and equitable documentation of a community's shared history. Art, though underutilized, can be an effective tool for sharing previously untold stories and documenting personal recollections. The “Baltimore '68” Mosaic Monument is an excellent example of how community arts can enrich a multifaceted historical project like the University of Baltimore's Baltimore '68: Riots and Rebirth initiative. This article reflects on the narrative behind the mosaic and how it became a true testament to the power of art and civic dialogue.
Characteristics and treatment of patients with G3 gastroenteropancreatic neuroendocrine neoplasms
Authors: Heetfeld M , Chougnet C N , Olsen I H , Rinke A , Borbath I , Crespo G , Barriuso J , Pavel M , O'Toole D , Walter T , _ _
Published: June 2015

Data on gastroenteropancreatic neuroendocrine neoplasms (NEN) G3 (well-differentiated neuroendocrine tumors (NET G3) and neuroendocrine carcinoma (NEC)) are limited. We retrospectively study patients with NET G3 and NEC from eight European centers. Data examined included clinical and pathological characteristics at diagnosis, therapies and outcomes. Two hundred and four patients were analyzed (37 NET G3 and 167 NEC). Median age was 64 (21–89) years. Tumor origin included pancreas (32%) and colon-rectum (27%). The primary tumor was resected in 82 (40%) patients. Metastatic disease was evident at diagnosis in 88% (liver metastases: 67%). Median Ki-67 index was 70% (30% in NET G3 and 80% in NEC;P<0.001). Median overall survival (OS) for all patients was 23 (95% CI: 18–28) months and significantly higher in NET G3 (99 vs 17 months in NEC; HR=8.3;P<0.001). Platinum-etoposide first line chemotherapy was administered in 113 (68%) NEC and 12 (32%) NET G3 patients. Disease control rate and progression free survival (PFS) were significantly higher in NEC compared to NET G3 (P<0.05), whereas OS was significantly longer in NET G3 (P=0.003). Second- and third-line therapies (mainly FOLFIRI and FOLFOX) were given in 79 and 39 of NEC patients; median PFS and OS were 3.0 and 7.6 months respectively after second-line and 2.5 and 6.2 months after third-line chemotherapy. In conclusion, NET G3 and NEC are characterized by significant differences in Ki-67 index and outcomes. While platinum-based chemotherapy is effective in NEC, it seems to have limited value in NET G3.
A nude mouse model of obesity to study the mechanisms of resistance to aromatase inhibitors
Authors: Schech Amanda , Yu Stephen , Goloubeva Olga , McLenithan John , Sabnis Gauri
Published: June 2015

Obesity is a risk factor for breast cancer progression. Breast cancer patients who are overweight or obese or have excess abdominal fat have an increased risk of local or distant recurrence and cancer-related death. Hormone depletion therapies can also cause weight gain, exacerbating the risk for these patients. To understand the effect of obesity on hormone-dependent human breast cancer tumors, we fed ovariectomized athymic nude mice a diet containing 45% kcal fat and 17% kcal sucrose (high fat sucrose diet (HFSD)), 10% kcal fat (low fat diet (LFD)), or a standard chow diet (chow). The mice fed the HFSD developed metabolic abnormalities consistent with the development of obesity such as weight gain, high fasting blood glucose, and impaired glucose tolerance. These mice also developed hyperinsulinemia and insulin resistance. The obese mice also had a higher tumor growth rate compared to the lean mice. Furthermore, the obese mice showed a significantly reduced responsiveness to letrozole. To understand the role of obesity in this reduced responsiveness, we examined the effect of insulin on the growth of MCF-7Ca cells in response to estrogen or letrozole. The presence of insulin rendered MCF-7Ca cells less responsive to estrogen and letrozole. Exogenous insulin treatment of MCF-7Ca cells also resulted in increased p-Akt as well as ligand-independent phosphorylation of ERα. These findings suggest that diet-induced obesity may result in reduced responsiveness of tumors to letrozole due to the development of hyperinsulinemia. We conclude that obesity influences the response and resistance of breast cancer tumors to aromatase inhibitor treatment.
15 YEARS OF PARAGANGLIOMA: Metabolism and pheochromocytoma/paraganglioma
Authors: Mannelli Massimo , Rapizzi Elena , Fucci Rossella , Canu Letizia , Ercolino Tonino , Luconi Michaela , Young William F
Published: June 2015

The discovery ofSDHDas a pheochromocytoma/paraganglioma susceptibility gene was the prismatic event that led to all of the subsequent work highlighting the key roles played by mitochondria in the pathogenesis of these tumors and other solid cancers. Alterations in the function of tricarboxylic acid cycle enzymes can cause accumulation of intermediate substrates and subsequent changes in cell metabolism, activation of the angiogenic pathway, increased reactive oxygen species production, DNA hypermethylation, and modification of the tumor microenvironment favoring tumor growth and aggressiveness. The elucidation of these tumorigenic mechanisms should lead to novel therapeutic targets for the treatment of the most aggressive forms of pheochromocytoma/paraganglioma.
15 YEARS OF PARAGANGLIOMA: Genetics and mechanism of pheochromocytoma–paraganglioma syndromes characterized by germline SDHB and SDHD mutations
Authors: Baysal Bora E , Maher Eamonn R
Published: June 2015

Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine neoplasms that derive from small paraganglionic tissues which are located from skull base to the pelvic floor. Genetic predisposition plays an important role in development of PPGLs. Since the discovery of first mutations in the succinate dehydrogenase D (SDHD) gene, which encodes the smallest subunit of mitochondrial complex II (SDH), genetic studies have revealed a major role for mutations in SDH subunit genes, primarily inSDHBandSDHD, in predisposition to both familial and non-familial PPGLs. SDH-mutated PPGLs show robust expression of hypoxia induced genes, and genomic and histone hypermethylation. These effects occur in part through succinate-mediated inhibition of α-ketoglutarate-dependent dioxygenases. However, details of mechanisms by which SDH mutations activate hypoxic pathways and trigger subsequent neoplastic transformation remain poorly understood. Here, we present a brief review of the genetic and mechanistic aspects of SDH-mutated PPGLs.
Ankaferd Blood Stopper Decreases Postoperative Bleeding and Number of Transfusions in Patients Treated with Clopidogrel: A Double-blind, Placebo-controlled, Randomized Clinical Trial
Authors: Akpinar Mehmet Besir , Atalay Atakan , Atalay Hakan , Dogan Omer Faruk
Published: June 2015

Background: The risk of reoperation due to bleeding after open heart surgery is 2.2%-4.2%. Patients who undergo reoperation have a two to six times greater mortality rate. Risk factors for reoperation include: older age, low body mass index, time on extracorporeal circulation, and emergency operations. In coronary artery bypass graft (CABG) patients who are treated preoperatively with antiplatelets, including clopidogrel, the source of postoperative bleeding may be difficult to detect. The aim of this study was to investigate the effectiveness of local Ankaferd blood stopper (ABS) to prevent mediastinal bleeding in CABG patients who were treated with clopidogrel and acetylsalicylic acid (ASA) preoperatively.
Methods: Twenty-five emergency CABG patients premedicated with clopidogrel and ASA as antiplatelet drugs were included in the study (Group 1). An additional twenty-five patients who were premedicated with the same antiplatelet agents were selected as a control group (Group 2). Preoperative clinical characteristics of the two groups were comparable. At the end of the surgery, 4-10 mL of ABS solution was sprayed on the mediastinal and epicardial tissue following protamine administration in Group1. We compared postoperative total mediastinal bleeding, reoperation rate and total blood and blood products transfused between the two groups.
Results: There was no mortality in either of the two groups. Mean postoperative bleeding was 430 mL in the ABS group, and 690 mL in the CG group (P = .044). In the ICU, bleeding in groups 1 and 2 was 610 mL and 980 mL, respectively (P = .025); total bleeding from the mediastinum was 830 mL and 1490 mL, respectively (P = .001) and the amount of autotransfusion was 210 mL and 400 mL (P = .003). Total transfusion of PRBCs in the operating room in groups 1 and 2 was 0.3 and 0.8, respectively (P = .003). No patients in the ABS group needed surgical revision due to severe bleeding or cardiac tamponade.
Conclusion: The use of local ABS reduces bleeding, transfusion requirements of packed red blood cells, platelets and total blood units in patients premedicated with clopidogrel and ASA undergoing emergent CABG .
Coronary Embolism Causing Acute Inferior Wall and Ventricular Myocardial Infarction in a Patient with Rheumatic Valvular Heart Disease: Treatment with Thrombus Aspiration
Authors: Du Xiao-Yu , Hui Peng , Zheng Yang
Published: June 2015

An elderly man with rheumatic valvular heart disease and atrial fibrillation presented with acute myocardial infarction. A coronary angiogram revealed complete occlusion of the right coronary artery (RCA), and we therefore considered that a thrombus might have obstructed the ostium of the RCA. We used a guiding catheter and the syringe of an aspiration device to remove two large dark red thrombi. A subsequent angiogram revealed that blood flow through the RCA had recovered, and the endomembrane of the RCA was smooth, with no evidence of stenosis or residual thrombus. In this case, thrombus aspiration via a guiding catheter was efficacious for treating this type of coronary embolism.
Oxygen Fraction Adjustment According to Body Surface Area during Extracorporeal Circulation
Authors: Arıtürk Cem , Özgen Serpil Ustalar , Danışan Behiç , Karabulut Hasan , Toraman Fevzi
Published: June 2015

Background: The inspiratory oxygen fraction (FiO2) is usually set between 60% and 100% during conventional extracorporeal circulation (ECC). However, this strategy causes partial oxygen pressure (PaO2) to reach hyperoxemic levels (>180 mmHg). During anesthetic management of cardiothoracic surgery it is important to keep PaO2 levels between 80-180 mmHg. The aim of this study was to assess whether adjusting FiO2 levels in accordance with body temperature and body surface area (BSA) during ECC is an effective method for maintaining normoxemic PaO2 during cardiac surgery.

Methods: After approval from the Ethics Committee of the University of Acıbadem, informed consent was given from 60 patients. FiO2 adjustment strategies applied to the patients in the groups were as follows: FiO2 levels were set as 0.21 × BSA during hypothermia and 0.21 × BSA + 10 during rewarming in Group I; 0.18 × BSA during hypothermia and 0.18 × BSA + 15 during rewarming in Group II; and 0.18 × BSA during hypothermia and variable with body temperature during rewarming in Group III. Arterial blood gas values and hemodynamic parameters were recorded before ECC (T1); at the 10th minute of cross clamp (T2); when the esophageal temperature (OT) reached 34°C (T3); when OT reached 36°C (T4); and just before the cessation of ECC (T5).

Results: Mean PaO2 was significantly higher in Group I than in Group II at T2 and T3 (P = .0001 and P = .0001, respectively); in Group I than in Group III at T1 (P = .02); and in Group II than in Group III at T2, T3, and T4
 (P = .0001 for all). 

Conclusion: Adjustment of FiO2 according to BSA rather than keeping it at a constant level is more appropriate for keeping PaO2 between safe level limits. However, since oxygen consumption of cells vary with body temperature, it would be appropriate to set FiO2 levels in concordance with the body temperature in the
 rewarming period.
Insertion of the Intraaortic Balloon Pump via the Ascending Aorta or the Aortic Arch Using the HEARTSTRING Proximal Seal System
Authors: Lamm Peter , Juchem Gerd , Reichart Bruno , Kilian Eckehard
Published: June 2015

Purpose: The HEARTSTRING Proximal Seal System is used to avoid aortic clamping to insert the intraaortic balloon pump (IABP) in the ascending aorta or the aortic arch. This technique is used when calcification or atheroma prevents side clamping of the ascending aorta or the aortic arch.

Description: A vein graft or a small-caliber vascular prosthesis for the later insertion of the IABP is sewn to the ascending aorta or the aortic arch using the HEARTSTRING Proximal Seal System.

Evaluation: In our department, this technique is applied whenever insertion of the IABP is not feasible via the femoral arteries. 

Conclusion: The technique allows the safe insertion of the IABP via the ascending aorta or the aortic arch.
Comprensión del concepto de emergencia, desde el aporte de Holland, Kauffman y Andrade
Authors: Montoya Restrepo Iván Alonso , Montoya Restrepo Luz Alexandra
Published: June 2015

Los procesos evolutivos están vinculados con el problema de la emergencia, la cual suele entenderse como una "aparición", que es explicada desde concepciones diferentes. Por una parte, en el programa de investigación de Holland en sistemas complejos adaptables (SCA), la adaptación de los agentes va a generar complejidad y emergencias. En el aporte de Kauffman, se sugiere que la biosfera se fabrica por sí misma, mediante la emergencia y persistente coevolución de agentes autónomos que desempeñan ciclos de trabajo. Finalmente, Andrade propone el papel de la forma como concepto que resuelve polaridades entre información digital y analógica, y el papel del registro y compresión de la información en la emergencia de nuevas posibilidades de organización. Ei presente documento explora estos aportes y presenta una visión conjunta.
Estrategias y realidades en la difusión de las redes sociales en las administraciones públicas. Análisis desde una perspectiva institucionalista
Authors: Criado J. Ignacio , Rojas-Martín Francisco
Published: June 2015

Este estudio pretende responder a varias preguntas de investigación en relación con el desarrollo de las herramientas Web 2.0 en la administración pública: ¿Cuáles son las principales estrategias planteadas para el fomento de las redes sociales? ¿Cuál es el nivel de desarrollo en el proceso de implementación de las redes sociales? ¿Cuál es el papel de las instituciones en las dinámicas de difusión tecnológica asociadas a las redes sociales dentro del sector público? Este artículo analiza la difusión de las redes sociales en las administraciones de las comunidades autónomas en España desde una perspectiva institucionalista. Esta corriente teórica pone el acento en el papel de las instituciones en el ámbito organizativo y trata de explicar las dinámicas de difusión tecnológica en las organizaciones a partir del estudio de las instituciones. Lo anterior se desarrolla en este artículo mediante el estudio de varias dimensiones sobre la difusión de las redes sociales en las administraciones objeto de estudio, entre otras, los años de experiencia de uso, los equipos humanos que los gestionan, la existencia o no de guías de uso que normalicen los criterios para su correcta utilización, la existencia o no de algún tipo de política y/o estrategia formal y las redes sociales específicas que las administraciones emplean. Metodológicamente, este trabajo está basado en un cuestionario enviado a los responsables de la gestión de las redes sociales de las administraciones regionales españolas. Esta investigación muestra que todavía no existe un diseño estratégico generalizado de las tecnologías sociales en las administraciones públicas analizadas o que existen variaciones de calado en la implantación de las mismas tecnologías. En cierta medida, ello sugiere la existencia de factores institucionales que explican los diferentes patrones de utilización en las organizaciones objeto de estudio. En suma, este artículo ofrece un análisis exhaustivo, si bien exploratorio, sobre el proceso de difusión de las redes sociales en las administraciones públicas.
The Influence of Social and Environmental Labels on Purchasing: An Information and Systematic-heuristic Processing Approach
Authors: Redondo Palomo Raquel , Valor Martínez Carmen , Carrero Bosch Isabel
Published: June 2015

This paper aims at exploring how social and environmental (SE) labels influence purchasing. By drawing on the information processing and the systematic-heuristic models, this study tests the process followed by consumers when purchasing SE labeled-products. Information was gathered through a structured questionnaire in personal interviews with 400 consumers responsible for household shopping of Fast-moving Consumer Goods (FMCG), who were randomly approached at shopping mails in four areas of Madrid, Spain. They were asked about recognition, knowledge, credibility, perceived utility and purchases on 12 different labels; the influence of these variables on purchase is modeled and tested by path analysis. This study suggests that a systematic-heuristic information processing occurs when consumers buy SE-labeled FMCG products, as the purchase of this type of goods depends on the recognition of a label, knowledge of the issue/issuer, as well as the credibility and the perceived utility of SE labels. Motivation for being informed influences the process, being an antecedent of awareness, comprehension and perceived utility. This model shows a dual processing mode: systematic and heuristic, where the lack of cognitive capacity could explain why these two processing modes co-occur. This paper adds value to existing literature on SE labels and consumption by applying the information processing model, which has not been used before in the field of responsible consumption, in addition to open a promising avenue for research, by offering complementary theories to the existing ones, based on attitudes.
El impacto diferenciado de la autoconfianza, los modelos de referencia y el miedo al fracaso sobre los jóvenes emprendedores
Authors: Gómez-Araujo Eduardo , Lafuente Esteban , Vaillant Yancy , Gómez Núñez Liyis Marilín
Published: June 2015

El objetivo principal de este trabajo es determinar el efecto que la autoconfianza en las habilidades emprendedoras y algunas variables socio-culturales (los modelos de referencia y el estigma social al fracaso) ejercen sobre la actividad emprendedora de los jóvenes en España. Con tal finalidad se realiza un modelo de regresión logística para eventos extranos, utilizando la base de datos GEM-España de 2009, con una muestra de 24.099 personas. Los resultados más importantes indican que los jóvenes son más emprendedores que las personas mayores. Además, los resultados muestran que la autoconfianza y el estigma social al fracaso empresarial tienen un efecto diferenciado sobre la probabilidad emprendedora de jóvenes espanoles.
LECUONA: CORPO E SENSAÇÃO EM MERLEAU-PONTY
Authors: Da Silva Thays Anyelle Macedo , Medeiros Rosie  Marie Do Nascimento
Published: June 2015

Nesta pesquisa, convidamos a uma reflexão fenomenológica sobre corpo e sensação em Merleau-Ponty. Como possibilidade de leitura, escolhemos  a obra  “Lecuona” da Companhia de Dança Grupo Corpo. Pretende-se aproximar tal obra do discurso filosófico, principalmente dando movimento aos pensamentos fenomenológicos de Maurice Merleau-Ponty, em especial sua tese do sensível e os conhecimentos do corpo, posto que aberturas no conhecimento de modo geral, e na Filosofia moderna especificamente, permitiram, no cenário epistemológico contemporâneo, pensar-se o corpo fenomenal, atravessado por emoções, portanto estesiológico, que permite operações e expressão. Diante disso, recorremos à atitude fenomenológica de Maurice Merleau-Ponty como percurso metodológico, já que em seus estudos o filósofo lança um olhar expressivo sobre o corpo, configurando uma linguagem sensível que é expressa nos movimentos, onde aprofunda as teses da Fenomenologia num novo arranjo para o conhecimento enquanto resultado de nossa experiência no mundo vivido. As reflexões apresentadas neste pesquisa pretendem levar-nos ao espanto, ao qual muitos desafios se impõem, entre eles a compreensão do corpo e do conhecimento sensível.
SER NO MUNDO, MUNDO VIVIDO E CORPO PRÓPRIO SEGUNDO MERLEAU-PONTY
Authors: Azevedo Denis De Souza , Caminha Iraquitan De Oliveira
Published: June 2015

Abordaremos, neste artigo, a conexão entre ser no mundo e mundo vivido, tendo como foco de nossa investigação o sentido de corpo próprio para Merleau-Ponty. Em outros termos, o que iremos expor aqui é o modo como o sujeito está situado no mundo pelo corpo e pelas suas ações intencionais. Destacaremos a noção de perspectiva como experiência fundante da percepção do corpo que “vê” e “se vê” ao mesmo tempo. Nesse sentido, o corpo, por sua vez, não pode ser reduzido a um mero objeto de estudo a ciência positiva. Tal corpo é, ao mesmo tempo, tocante e tocado, que sente e é sentido. Ele é, neste emaranhado de passividades e atitudes, uma mescla de afetar e ser afetado. Pois, de um só golpe, nosso corpo é coisa e sujeito. Sendo assim, a nossa visão perspectivista sobre algo é de tal modo que conseguimos ultrapassá-lo por meio dos movimentos intencionais que nos possibilita considerar o objeto a partir de certos ângulos e com infinitas possibilidades de aparições.
MOVIMENTOS DO PENSAMENTO: CENÁRIOS DA FILOSOFIA DO CORPO NO BRASIL
Authors: Da Nóbrega Terezinha Petrucia , Silva Liege Monique Filgueiras , De Lima Neto Avelino Aldo
Published: June 2015

O presente artigo tem por objetivo apresentar um panorama geral dos estudos de Filosofia do Corpo no Brasil. Partimos de uma contextualização filosófica acerca desse domínio de estudos para, em seguida, descrever a paisagem histórica de seu percurso no país. Posteriormente, apresentamos um recorte das pesquisas desenvolvidas no país de 2011 a 2012, concentrando-nos nos âmbitos dos programas de pós-graduação em Filosofia e em Educação. Por fim, analisamos as implicações epistemológicas dos atuais estudos e traçamos possibilidades de sua continuidade no cenário brasileiro de investigação.
Prospective Clinical Utility Study of the Use of the 21-Gene Assay in Adjuvant Clinical Decision Making in Women With Estrogen Receptor-Positive Early Invasive Breast Cancer: Results From the SWITCH Study
Authors: Gligorov Joseph , Pivot Xavier B. , Jacot William , Naman Hervé L. , Spaeth Dominique , Misset Jean-Louis , Largillier Rémy , Sautiere Jean-Loup , de Roquancourt Anne , Pomel Christophe , Rouanet Philippe , Rouzier Roman , Penault-Llorca Frederique M. ,   for The Francilian Breast Intergroup
Published: June 2015

Background.

The 21-gene Oncotype DX Recurrence Score assay is a validated assay to help decide the appropriate treatment for estrogen receptor-positive (ER+), early-stage breast cancer (EBC) in the adjuvant setting. The choice of adjuvant treatments might vary considerably in different countries according to various treatment guidelines. This prospective multicenter study is the first to assess the impact of the Oncotype DX assay in the French clinical setting.

Methods.

A total of 100 patients with ER+, human epidermal growth factor receptor 2-negative EBC, and node-negative (pN0) disease or micrometastases in up to 3 lymph nodes (pN1mi) were enrolled. Treatment recommendations, physicians’ confidence before and after knowing the Recurrence Score value, and physicians’ perception of the assay were recorded.

Results.

Of the 100 patients, 95 were evaluable (83 pN0, 12 pN1mi). Treatment recommendations changed in 37% of patients, predominantly from chemoendocrine to endocrine treatment alone. The proportion of patients recommended chemotherapy decreased from 52% pretest to 25% post-test. Of patients originally recommended chemotherapy, 61% were recommended endocrine treatment alone after receiving the Recurrence Score result. For both pN0 and pN1mi patients, post-test recommendations appeared to follow the Recurrence Score result for low and high values. Physicians’ confidence improved significantly.

Conclusion.

These are the first prospective data on the impact of the Oncotype DX assay on adjuvant treatment decisions in France. Using the assay was associated with a significant change in treatment decisions and an overall reduction in chemotherapy use. These data are consistent with those presented from European and non-European studies.

Implications for Practice:

This study shows that in estrogen receptor-positive, human epidermal growth factor receptor 2-negative early breast cancer (either node-negative or with micrometastases in up to 3 lymph nodes), Oncotype DX testing is associated with a treatment recommendation change in more than a third of patients (primarily from chemoendocrine treatment to endocrine treatment alone but also in the opposite direction) and an overall reduction in chemotherapy use. These results are consistent with those from other decision impact studies worldwide and further emphasize the role of Oncotype DX testing in management of early breast cancer, as reflected in international treatment guidelines.
Comunidades de Aprendizaje, un Sueño que hace más de 35 años que Transforma Realidades
Authors: Morlà Folch Teresa
Published: June 2015

Learning Communities began over 35 years ago. In this article, the history of this movement is analyzed with the goal of understanding its evolution, the keys to its growth and success from a historical perspective, focusing on the overcoming of difficulties that this movement have found. To prepare this study, the existing literature on the subject have been analyzed, and interviews with leading figures in its development have been conducted. Results allow us to highlight the historical evidences that explain the evolution of the movement and hold its growth and success.
Los Límites de las Políticas Culturales y Educativas en la Construcción del Nuevo Hombre Fascista
Authors: Domínguez Méndez Rubén
Published: June 2015

Mussolini proposed the creation of a new man who was supposed to serve a general modernization of Italian society. To this end, fascism introduced to the masses in the political, economic, legal and, of course, cultural and educational system defended by fascist doctrine. This paper analyzes the cultural and educational policies developed by fascism in to build the new man. We study the values of this fascist man and the institutions responsible for that “creation” to show, finally, the limitations of these policies to achieve the expected results.
You Made El Team-O! The Transnational Browning of the National Basketball Association through the “Noche Latina” Marketing Campaigns
Authors: Moraga Jorge E.
Published: June 2015

This essay pushes beyond the black-white binary in an effort to expand understandings into the relationship between sport, Latinidad, and global capitalism in the 21st century. Through a discursive analysis into the National Basketball Association (NBA) outreach policies, I ask: do recent shifts in the NBA’s marketing strategies, while alluding towards social inclusion and multicultural diversity, also contribute to the containment, exclusion, and marginalization to the fastest growing minority group in the United States: the Latina/o. By conducting a textual analysis into the NBA’s Noche Latina campaign, this essay makes the case that while the NBA may be another example of browning the sporting gaze the gaze remains fixed upon Western capitalist notions of identity and representation. An aim of this study seeks to highlight the contradictions within U.S. based-sport marketing in hopes that sport fans, pundits and academics alike might grapple with and strive towards understanding how phenomena like “Noche Latina” repackages racialized, sexist and cultural tropes for global television audiences and social media users alike.
Experiences and Perceptions of Young Adults with Physical Disabilities on Sports
Authors: Wickman Kim
Published: June 2015

People with disabilities seldom get a chance to voice their opinions on their sport experiences. A deeper understanding of the context-related experiences of sport is a prerequisite for teachers and leaders to be able to provide adequate, inclusive and meaningful activities. The aim of this qualitative case study was to examine how young people with disabilities made sense of sport, within both the compulsory school system and the voluntary sports movement. The study involved 10 young adults (aged 16 to 29 years) with disabilities, five males and five females. All the participants had rich experiences of sport. An inductive approach to qualitative content analysis of semi-structured interviews was used to enable individuals to explain and give meaning to their experiences of sport including those pertaining to gender and inclusion. The findings illustrated that dominating gender and ability norms influenced the interviewees’ understanding of themselves in relation to sport; as a consequence, some of the female interviewees had a more diverse, sometimes contradictory experience of sport than the male interviewees. The basic premise of this study is that researchers can develop more insightful understandings of inclusion by studying the subjective meanings that are constructed by people with disabilities in their sport experiences.
Sport, Social Exclusion and the Forgotten Art of Researching Poverty: Book Review of Sport and Social Exclusion (2nd ed.). By Mike Collins and Tess Kay. New York: Routledge, 2014, 320 pp.; ISBN: 978-0-415-56880-7.
Authors: Haudenhuyse Reinhard
Published: June 2015

Book Review of Sport and Social Exclusion (2nd ed.). By Mike Collins and Tess Kay. New York: Routledge, 2014, 320 pp.; ISBN: 978-0-415-56880-7.
Recepção literária do domínio holandês no Brasil e em Angola
Authors: Figueiredo Maria Do Carmo Lanna
Published: June 2015

Leitura dos romances A rainha dos cárceres da Grécia (1975), deOsman Lins, e A gloriosa família, o tempo dos flamengos (1999), de Pepetela,que adotaram como motivo a presença holandesa em dois espaçoslusófonos, Brasil e Angola, com o objetivo de acompanhar como o viéstransnacional dessas sociedades, advindo da interação conflituosa e/oupacífica entre diferentes culturas, já se manifesta desde o século XVII;analisar os procedimentos textuais que promovem a ligação entre a históriae a literatura, o presente e o passado.
FERRAZ, Eucanaã. Rua do mundo. São Paulo: Companhia das Letras, 2004.
Authors: Amorim Bernardo Nascimento de
Published: June 2015

Resenha.
No fluxo das águas: jangadas, margens e travessias
Authors: Junior Benjamin Abdala
Published: June 2015

A partir da análise de imagens do filme Diários de motocicleta,de Walter Salles, são discutidos os sentidos da travessia do rio Amazonaspelo estudante Ernesto Guevara de La Serna, quando dialoga com astravessias da obra de Guimarães Rosa e, em especial, com o conto“Orientação”, da coletânea Tutaméia. O rio Amazonas é nuclear paraessas observações. Em torno dele, são enfocados ainda os romances Ajangada, de Júlio Verne; o filme Fitzcarraldo (o preço de um sonho), deHerzog; e escritos de Euclides da Cunha. Um dos temas centrais deGuimarães Rosa, a travessia, serve de motivo para a discussão depapéis do intelectual e da integração latino-americana.
A branca sintaxe na poética de Haroldo de Campos
Authors: Guimarães Rodrigo
Published: June 2015

Este ensaio busca rastrear a poesia de Haroldo de Campos apartir do conceito de sintaxe branca, com o propósito de elucidaralguns procedimentos operados na materialidade da linguagem. Paratanto, foram analisados, especialmente, os livros Galáxias e Crisantempo.
O mais simples poema a ver: Ave e Solida
Authors: Nova Vera Casa
Published: June 2015

Este ensaio apresenta questões ligadas ao livro-objeto,ou livropoema,decorrentes do Poema Concreto e Poema Processo, que secolocam na contemporaneidade,tais como a abertura radical dossentidos e as novas formas de ler.
Da Poesia Concreta à poesia visual
Authors: Castro E. M. de Melo e
Published: June 2015

Reflexões acerca da poesia concreta, não apenas como movimentode vanguarda, mas em relação a toda a poesia moderna.
Iconicidade e isomorfismo em poemas concretos brasileiros
Authors: Clüver Claus
Published: June 2015

Este trabalho examina a iluminação diferente em que, 50anos depois de formulada a teoria concreta, o tema se desdobra sob aperspectiva pós-concreta.
Roda Gigante: Conversa com o escritor
Authors: Araújo Laís Corrêa de
Published: June 2015

Entrevista realizada com Haroldo de Campos para ser publicadana coluna “Roda Gigante”, assinada por Laís Corrêa de Araújo, no JornalEstado de Minas, em 13 de agosto de 1961.
Os simbolistas: virando o século
Authors: Lins Vera
Published: June 2015

O artigo examina os escritores simbolistas da virada do séculoXIX, concentrando-se nos ensaios de dois críticos: o crítico de arte eficcionista, Gonzaga Duque e o crítico de literatura e também ficcionista,Nestor Victor. Em ambos pode-se observar uma reflexão sobre a arte e acultura brasileira original e já moderna.
Fulgurações de uma ilha: análise de um poema de Eucanaã Ferraz
Authors: Amorim Bernardo Nascimento de
Published: June 2015

Neste artigo, apresento uma análise do poema “Arquitetura nailha”, escrito por Eucanaã Ferraz, um dos poetas brasileiros contemporâneosde maior destaque. Para a leitura, aproveito, como referencial teórico, aslições de Antonio Candido, expostas em seu livro O estudo analítico dopoema.
Flashes da cidade
Authors: Cury Maria Zilda Ferreira
Published: June 2015

No romance eles eram muitos cavalos, de Luiz Ruffato, apresentamse60 flashes da cidade de São Paulo, imagens captadas por um narrador,muitas vezes, com um olhar repleto de compaixão. Tal olhar confere umsentido ético às narrativas.
Imagens da mulher na narrativa brasileira
Authors: Dalcastagnè Regina
Published: June 2015

A partir de uma extensa pesquisa que mapeou todos os romancesbrasileiros publicados pelas três editoras mais importantes do país entre osanos 1990 e 2004, discute-se como se dá a representação das personagensfemininas, tanto em obras de escritoras mulheres quanto de escritores homens.Um estudo inicial mostrou que estas personagens – quase todas brancas e declasse média – tendem a exercer papéis sociais tradicionais (mãe, esposa, donade-casa) e a permanecer encerradas na esfera doméstica. Isto é, a condição damulher avançou mais na sociedade do que na literatura. Agora, a partir deuma amostra de cerca de 150 personagens femininas, analisa-se em profundidadecomo a mulher é representada no romance brasileiro contemporâneo, abordandoquestões como corpo, sexualidade e maternidade, observando-se as diferençasnos enfoques de escritoras mulheres e de escritores homens.
A fala interminável: As iniciais, de Bernardo Carvalho
Authors: Ravetti Graciela
Published: June 2015

Comentário crítico sobre o romance As iniciais, de BernardoCarvalho, à luz de conceitos elaborados a partir da leitura de certas linhas daliteratura contemporânea na América Latina.
TREVISAN, Dalton. Macho não ganha flor. Rio de Janeiro: Record, 2006.
Authors: Peixoto Sérgio Alves
Published: June 2015

Resenha.
Anonimato e resistência em eles eram muitos cavalos, de Luiz Ruffato
Authors: Walty Ivete Lara Camargos
Published: June 2015

Análise do livro eles eram muitos cavalos, de Luiz Ruffato, em seudiálogo com a história da literatura brasileira, a partir da relação entreanonimato, exclusão social, lixo e vida urbana.
De Dom Casmurro a Capitu: transferências e interferências textuais problemáticas
Authors: Cunha João Manuel dos Santos
Published: June 2015

O ensaio investiga a tradução fílmica Capitu (Paulo Cezar Saraceni,1968) para o romance Dom Casmurro (Machado de Assis, 1899),intermediando a análise com o roteiro cinematográfico Capitu (Paulo EmilioSalles Gomes, Lygia Fagundes Telles, [1967] 1993), com o intuito de problematizaro alcance e a eficácia da operação transtextual intentada pelos tradutoresquanto ao estatuto do narrador em textos de ficção literária e cinematográfica.
Machado de Assis: o cronista e a construção da metrópole textual
Authors: Teixeira Níncia Cecília Ribas Borges
Published: June 2015

A pesquisa pondera as relações entre literatura e experiência urbana;sob essa perspectiva faz-se o levantamento das representações da cidade do Riode Janeiro, recém-inserida na modernidade e que ainda comporta vestígios dopassado colonial. O trabalho tem como objeto central a análise das crônicasproduzidas por Machado de Assis, escritor que pode ser considerado retratistade um Rio que se modernizava. O estudo dessas crônicas considera, além doenfoque literário, a configuração histórica e o forte apelo jornalístico dessegênero, que, até pouco tempo, era desconsiderado pelo cânone literário.
De Aires a Ayres: o conselheiro sem conteúdo
Authors: Bylaardt Cid Ottoni
Published: June 2015

Este texto procura mostrar a metamorfose operada no personagemAires de Esaú e Jacó para o Ayres de Memorial de Ayres, obra derradeira deMachado de Assis. Essa mudança pressupõe uma nova concepção de escritaliterária em direção à rarefação, ao inacabamento, ao mesmo tempo em quea veia irônica do escritor se aplaca neste último romance, dando lugar a umacompreensão mais serena da vida e da velhice, e a uma concepção de escritamenos comprometida com modelos e convenções. É a linguagem fora do poder,que não funda nem alimenta certezas, construída em suas ambigüidades, emsua incompletude. O texto não tem planos para o futuro, não é fruto de umprojeto, mas um mergulho irresponsável no reduto das sereias, no inferno deEurídice. Dessa forma o personagem-escritura de Memorial de Ayres percorreseu território infinito, carente de limitações que estabeleçam uma ordem.
Memórias póstumas da escravidão
Authors: Duarte Eduardo De Assis
Published: June 2015

A morte do senhor de escravos faz-se presente de diversas formas nosromances de Machado de Assis. Em Brás Cubas e Memorial de Aires, compõeo enredo e tem seus desdobramentos inseridos na ação. Já noutras narrativas,o pater familias é incorporado às tramas já morto, fazendo-se presente inabsentia na vida de viúvas e herdeiros, como em Helena ou Dom Casmurro.A partir desta constatação, o presente trabalho objetiva ler o motivo recorrenteda morte do senhor como enunciação machadiana do fim do regime, e discutira forma como tais romances narram as relações entre senhores e escravos noBrasil e inscrevem a decadência do patriarcado escravista.
Santiago Nunes Ribeiro e José de Alencar: filhos presentes da literatura brasileira
Authors: Peloggio Marcelo
Published: June 2015

O artigo tem como objetivo traçar um paralelo entre os dois autores acerca da formação de nossa nacionalidade literária, no sentido de se pôr em destaque o pensamento de José de Alencar para a sua renovação e incremento.
O espaço do fantástico como leitor das diferenças sociais: uma leitura de “O homem cuja orelha cresceu”
Authors: Khalil Marisa Martins Gama-
Published: June 2015

O conto “O homem cuja orelha cresceu”, de Ignácio de LoyolaBrandão, será analisado por intermédio de uma perspectiva que terá por objetivo demonstrar que a narrativa fantástica pode se abrir como espaço de crítica social, ainda que ela trabalhe com situações que fogem às práticas cotidianas. A direção transgressora e desestabilizadora da ambientaçãofantástica, que desencadeia no leitor a hesitação, permite que a literatura fantástica, ao enredar o inexplicável, promova a reflexão sobre acontecimentos cotidianos e explicáveis. Ao trabalhar com um protagonista cuja orelha crescecontínua e assustadoramente, a narrativa expõe a problemática do “mesmo” em contraposição ao “diferente”. As diferenças corporais configuram-se, no conto e na sociedade, como deformações, monstruosidades; o que foge à regradeve imediatamente realinhar-se a ela ou ser exterminado, como se sugere no final do conto. Para ampararmos nosso enfoque, partiremos das noções de Michel Foucault sobre práticas de subjetivação; de Gilles Deleuze e FélixGuattari acerca do liso e do estriado; de Umberto Eco sobre a feiúra e sobre o sublime; de Roland Barthes sobre mimese; e de Seligmann-Silva e de Beatriz Sarlo acerca da exposição dos traumas e tragédias humanas pela palavra metamorfoseada da literatura.
L’orangé et le bleu chez Cendrars, simultanément
Authors: Enrico Philippe
Published: June 2015

Lors de leur première rencontre à Paris en 1923, Blaise Cendrars offre à Tarsila do Amaral une petite peinture à l’huile sur carton, intitulée depuis Torre Eiffel, une des rares peintures que Cendrars ait peintes, dix ans auparavant, avec les couleurs de son ami Robert Delaunay. Vingt-deux ans après son dernier séjour au Brésil, Cendrars va dédier à Tarsila le dernier récit de ses mémoires, qui a pour décor la fazenda du “Morro Azul” d’un certain Oswaldo Padroso, l’inventeur d’une nouvelle constellation, la “Tour Eiffel Sidérale”, qui va donner son nom au récit. Dans l’ambivalence des contrastes simultanés, orangés de la passion et bleus de l’introspection vont se mêler une vie durant, tout comme aventure et écriture, la braise couvant sous la cendre, tel que le poète nous le chante pour toujours.
Augusto Meyer
Authors: Reis Nelson Ricardo Guedes dos
Published: June 2015

Este ensaio pretende demonstrar a presença de um discurso “poético”na obra crítica de Augusto Meyer. Com este objetivo fizemos um levantamento de seu percurso literário e nos dedicamos à análise de trechos de alguns de seus ensaios da maturidade.
“A chinela turca”
Authors: Boechat Maria Cecília
Published: June 2015

Comentário ao conto “A chinela turca”, de Machado de Assis, tendo em vista a incorporação e transformação de procedimentos folhetinescos realizada pela narrativa. Afirma-se, então, o diálogo entre a literatura do autor e esse gênero de narrativas, intensamente traduzido e praticado por autores nacionais durante o século XIX.
Em torno de laços de família
Authors: Versiani Ivana
Published: June 2015

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O branco no branco (a ''Fábula de Anfion'', de João Cabral)
Authors: Miranda Wander Melo
Published: June 2015

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Componentes populares de Grande Sertão: Veredas
Authors: Mendes Lauro Belchior
Published: June 2015

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O paradoxo da totalidade Em Grande Sertão: Veredas - coincidentia et separatio oppositorum
Authors: Almeida Ana Maria De
Published: June 2015

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“A literatura é uma transfiguração da realidade”. Entrevista com Antonio Candido
Authors: Fischer Luís Augusto
Published: June 2015

A entrevista a seguir foi concebida por Luís Augusto Fischer (UFRGS) com a colaboração de Homero Araújo (UFRGS), Ian Alexander (PUCRS), por Marcelo Frizzon (UFRGS) e Tatiana Tavares (UFRGS), responsável pela produção objetiva do trabalho. Por ocasião do cinquentenário do lançamento da Formação da Literatura Brasileira, foram propostas a Antonio Candido algumas questões sobre o livro, até hoje uma referência marcante no debate crítico. O resultado foi esta entrevista, publicadapela primeira vez no Caderno Cultura, da Zero Hora, em Porto Alegre, dia 24 de outubro de 2009.
Sobre a Formação da Literatura Brasileira
Authors: Alves Luis Alberto Nogueira
Published: June 2015

O presente estudo discute Formação da literatura brasileira como um clássico da crítica e da historiografia literária brasileira, enfatizando o método desenvolvido por Antonio Candido, ao mesmo tempo em que comenta as antigas e as novas objeções dirigidas ao autor.
Navegando no mar texto das galáxias. Onde está o ‘quem do conto’? o herói sem nenhuma resposta
Authors: Carvalho Maria Aparecida Oliveira de
Published: June 2015

Este estudo propõe uma leitura do fragmento 47 de Galáxias, livro de Haroldo de Campos, percorrendo seus diversos jogos de espelhos com a linguagem, a literatura mundial, os espaços e os tempos. O texto em questão se apresenta como um talismã, uma pseudofábula que se constrói como uma viagem literária referencial e autorreflexiva, assim como todos os outros fragmentos de Galáxias, que se inserem numa tradição de literatura mundial de vanguarda, na companhia dos grandes textos do século XX como os Cantos de Pound, Finnegans Wake de Joyce, entre outros.
Espaço e ambiência em poesia digital
Authors: Ferreira Ana Paula
Published: June 2015

Este artigo investiga as possibilidades que o meio digital abre para o texto poético, assim como as consequências que os ambientes do ciberespaço podem trazer para esse tipo de processo, nas formulações de Peter Sloterdijk e Martin Heidegger.
escrita de Um homem sem profissão
Authors: Mendes Lauro Belchior
Published: June 2015

Estudo comparativo do romance Memórias sentimentais de João Miramar e do livro de memórias Um homem sem profissão, de Oswald deAndrade, com o objetivo de mostrar as marcas do primeiro texto sobre o segundo e o processo de escrita antropofágica, presente em ambos.
discurso polivalente de Guimarães Rosa
Authors: Aguiar Melânia Silva de
Published: June 2015

Ensaio de caráter introdutório à leitura de Grande sertão: veredas, de Guimarães Rosa, em que se delineiam as principais forças do romance: as referências contextuais (real geográfico), a idealização cavaleiresca (real analógico), as dimensões metafísica (real transcendente) e psicológica (real psíquico).
feição nativista/indianista de Mário de Andrade
Authors: Carvalho Fábio Almeida de
Published: June 2015

O artigo examina o modo por que Mário de Andrade dá continuidade – em diapasão gravemente dissonante – ao legado nativista-indianista do romantismo literário brasileiro.