bluuebunny/crossref_metadata_2025 huggingface dataset:
ESPECTROS DA ATUAÇÃO DO AMICUS CURIAE NA CORTE IDH E NO STF:
Authors: Maas Rosana Helena , Delazeri Luiz Henrique
Published: November 2024

O artigo tem como objetivo analisar o instituto do amicus curiae nas ações do controle concentrado de constitucionalidade do ordenamento jurídico brasileiro e na Corte Interamericana de Direitos Humanos, no que atine, especificadamente, à sua forma de manifestação e contribuição à lide, na defesa e garantia dos direitos fundamentais e humanos. Com o presente trabalho, almeja-se apresentar a importância da intervenção do instituto na jurisdição nacional e interamericana na atualidade, tendo em vista a tradição do instituto. Desse modo, as problemáticas a serem respondidas, correspondem: quais são as formas de intervenção do instituto do amicus curiae no controle concentrado de constitucionalidade do ordenamento jurídico brasileiro e na Corte IDH? Qual é a importância atual do instituto nesses lócus? Para elaboração da pesquisa, utiliza-se do método dedutivo e da técnica pautada de pesquisa bibliográfica e jurisprudencial. Nessa perspectiva, o trabalho se justifica pela importância de evidenciar que o instrumento jurídico corresponde a um mecanismo de contribuição e legitimidade no âmbito das decisões do Supremo Tribunal Federal e da Corte Interamericana de Direitos Humanos, intervindo nas formas voluntárias e por requisição do relator, possuindo como princípio maior possibilitar a concretização, proteção e garantia dos direitos humanos e fundamentais.
Fibroblast Heterogeneity in Hepatocellular Carcinoma and Identification of Prognostic Markers Based on Single-cell Transcriptome Analysis
Authors: Jia Junjun , Gu Xinyu , Chu Qingfei
Published: November 2024

Background:

HCC is a malignant tumor with high morbidity and mortality. Fibroblasts
play a key role in the tumor microenvironment (TME). However, the transcriptional
regulatory mechanisms of fibroblasts remained unclear in HCC.

Aim:

The aim of this study was to explore the complex role of fibroblasts in hepatocellular
carcinoma (HCC) and to reveal their transcriptional regulatory mechanisms.

Objective:

The goal of this study was to discover potential prognostic markers for HCC by
analyzing the genetic variations and differentiation process of fibroblasts.

Methods:

Single-cell transcriptome data from the non-tumor liver site and primary tumor
site of HCC were acquired from GSE149614, processed, and clustered using the Seurat pipeline.
The inferCNV algorithm was applied to infer copy number variations (CNVs) in fibroblasts.
Subsequently, the mechanism underlying the interaction between fibroblasts and
other cells in the TME of HCC was analyzed using CellChat software. The trajectory of cellular
differentiation of fibroblasts from normal state to malignant state was examined using
Monocle 2. SCENIC analysis was performed to identify key transcription factors (TFs) in fibroblasts
and assess their correlation with HCC prognosis. Finally, qRT-PCR and Transwell
assays were carried out to analyze the mRNA expression and cell metastasis.

Results:

We identified a total of nine different cell types (B cells, cycling cells, endothelial
cells, epithelial cells, fibroblasts, hepatocytes, macrophages, plasma cells, and T cells)
based on the single-cell transcriptomic data of HCC. Among them, fibroblasts were highly
enriched at the primary tumor site, and their number increased with advanced stages. In addition,
significant deletions were detected on chromosome 6p of fibroblasts, and genes in this
region were remarkably enriched in pathways associated with antigen processing and presentation.
Intercellular communication showed that epithelial cells regulated fibroblasts the
most. The differentiation of fibroblasts was mainly accompanied by a transition from normal
to malignant state. Importantly, CEBPD and FOSB, the TFs most associated with the
putative timing of fibroblasts, were under-expressed in human hepatocytes and showed a significant
correlation with HCC prognosis. Overexpressed CEBPD inhibited HCC cell migration
and invasion.

Conclusion:

In conclusion, our study revealed that fibroblast recruitment and differentiation,
as well as copy number loss at chromosome 6p, were associated with a higher degree
of malignancy and immune dysfunction in HCC. The current discoveries provided new insights
into the clinical treatment and diagnosis of HCC.
Perspectives on Ergodic Cancer Therapy Derived from Cloning Genome Chaos via In Vivo Rhabdomyosarcoma RA-2 Models: a Narrative Review
Authors: Shityakov Sergey , Lubinets Natalia , Kravtsov Viacheslav
Published: November 2024

This review explores articles concerning the experimental research cycle on genome
instability in cell populations of highly malignant recurrent organotropic rhabdomyosarcoma RA-
2 in rats. Clonal analysis and cloning were pivotal components of this research, which relies on the
frequency of cells with micronuclei and internuclear bridges to gauge the intensity of chromothripsis
and break-fusion-bridge cycles. The efficacy of cloning, determined by these indicators,
stemmed from the deliberate isolation of tumor stem cells, yielding clones in which chromothripsis
activity and breakage-fusion-bridge cycles were sustained. Notably, it is plausible that the stem
cells themselves, progenitors of these clones, harbor dicentric chromosomes and chromosomal fragments,
contributing to the formation of "fatal micronuclei" in their karyotype. Cloning based on
bridges and micronuclei has proven effective up to a certain threshold (15%-18%), reaffirming the
predicted reproductive extinction of malignant cell populations under mutational pressure and genome
chaos, as posited by the genetic theory of cell populations. Furthermore, this review highlights
the potential of ergodic cancer therapy as a novel therapeutic strategy. Ergodic therapy offers promising
prospects for late-stage and terminal malignant tumors, where conventional treatments may
fall short due to advanced progression. Furthermore, by "enhancing chromothripsis" through the
induction of additional micronuclei and bridges, ergodic cancer therapy seeks to increase genome
chaos to a critical threshold, potentially halting malignant progression. This innovative approach
presents opportunities to explore new drugs and targets for chromothripsis-based oncotherapy, addressing
the pressing need for effective treatments in advanced stages of malignancy.
Chiral Ionic Liquids as Stationary Phases in Electrophoretic Separations
Authors: Kaur Manpreet , Malik Ashok Kumar
Published: November 2024

Ionic liquids (ILs) are exceptional solvents having melting points at or
below 100 0C. They are completely made up of ions, often consisting of an organic
cation and an inorganic or organic anion. ILs having chiral moiety are referred to as
chiral ionic liquids (CILs). Cations, anions, or both can be chiral in CILs. A CIL can
have chiral azolinium, imidazolium, ammonium, or pyridinium as its chiral cationic
component. Lactic acid, borate, or camphor sulfonate are some examples of the chiral
anion. CILs have recently been used in electrophoretic techniques in different forms,
such as chiral ligands, background electrolyte (BGE) additives, chiral selectors, and
chiral stationary phases for the separation of chiral compounds. As they integrate the
benefits of ILs and the features of a chiral moiety, they are thought to be particularly
fascinating in chiral investigation. Notably, the use of CILs as chiral selectors offers
advantages over other chiral selectors whose employment is typically constrained by a
few issues, such as high-temperature instability, high UV absorptivity, complex
synthetic methodologies, low solubility, and expensive nature. Therefore, it is crucial to
consider how CILs can be used as solvents and chiral selectors. In this chapter, the
diverse applications of chiral ionic liquids as stationary phases in electrophoretic
separations are discussed in detail.
Chiral Ionic Liquids and Chromatography: Synergistic Effects in Enantioseparations
Authors: Bhogal Shikha , Mohiuddin Irshad , Kumar Sandeep , Berhanu Asnake Lealem , Kaur Kuldeep , Malik Ashok Kumar
Published: November 2024

Chiral ionic liquids (CILs) are a subcategory of ionic liquids that possess a
chiral moiety. The need for chiral separations in several industries, including
pharmaceutical, food, and chemical industries, has led to an increasing search for
materials capable of performing such separations. CILs have emerged as effective
candidates for the separation of enantiomers because of their advantageous properties
like low melting point, little vapor pressure, high thermal stability, good electrical
conductivity, and low cost. They are being employed in chromatographic methods as
chiral ligands, stationary phases, and chiral selectors for the separation of chiral
compounds. As compared to other chiral selectors (cyclodextrins, polysaccharides,
surfactants, and crown ethers), CILs show better solubility, easy synthesis, and low
cost. They represent an intriguing opportunity for use in chromatography because of
their wide range of solubility in organic and inorganic solvents, as well as their
miscibility with common solvents (methanol and acetonitrile). Considering the
flourishing research in the field, the present chapter summarizes the advancement in the
application of CILs as chiral ligands, stationary phases, and chiral selectors in liquid
and gas chromatographic techniques. Furthermore, the chiral recognition mechanism
and prospects for the use of CILs in enantioseparations have been examined.
Striking Back, Striking Now: Navigating the Legality of Extra-Territorial Armed Responses to Terrorist Attacks Originating from Abroad
Authors: Pronesti Dario
Published: November 2024

The use of force against terrorism remains a widely debated matter among scholars. This article aims to show that taking forcible measures in response to terrorist attacks is consistent with the rules of jus ad bellum, even in non-consensual extra-territorial settings. Post-9/11 state practice and opinio juris support the view that terrorist attacks may amount to fully-fledged armed attacks. Yet, it is still unclear if and when a State victim of terrorism may intervene against terrorists located outside its territory. While the question would be irrelevant where the host State intervened against the terrorists present on its territory, it would not be so if it were unwilling or unable to act. In such a scenario, the victim State would have to choose between compromising its territorial integrity or that of its counterpart. It is against this background that the “Unwilling or Unable” doctrine will be evaluated in this article.
Megastigma acarrilloi (Rutaceae), una especie nueva de Sinaloa, México, con la distribución más septentrional del género
Authors: Pío-León Juan Fernando
Published: November 2024

Antecedentes y Objetivos: El género Megastigma cuenta con seis especies descritas de arbustos que se distribuyen desde Colima, México, hasta Nicaragua. Mediante la revisión rutinaria de la plataforma iNaturalistMX en 2023 se observó el registro de un individuo del género Megastigma, aunque en una localidad muy disjunta con respecto a las especies conocidas. La colecta de los ejemplares y su revisión posterior permitieron determinar que se trataba de una especie nueva para la ciencia.Métodos: Se realizaron exploraciones y colectas botánicas durante 2023 y 2024 en la Sierra de Barobampo, municipio Ahome, Sinaloa, México. La identidad de la especie se determinó mediante revisión de literatura especializada. Se elaboró un mapa con la distribución de cada especie del género mediante los datos disponibles en repositorios digitales y ejemplares en el herbario MEXU. Se evaluó y propuso el estado de conservación de la nueva especie de acuerdo con los criterios de la UICN. Se proporciona una clave para la identificación de todas las especies del género Megastigma.Resultados: Megastigma acarrilloi es endémica del norte de Sinaloa, México, y posee la distribución más septentrional del género. La especie con mayor afinidad morfológica es M. morenoi, endémica de Colima. Megastigma acarrilloi se diferencia de esta porque es glabra y posee menor número de folíolos por hoja. Durante las exploraciones se observaron larvas de lepidópteros del género Papilio alimentándose de sus hojas. Se recomienda incluir a M. acarrilloi como especie Vulnerable (VU) en la Lista Roja de la IUCN.Conclusiones: Con la nueva especie, el género Megastigma queda integrado por siete especies, todas presentes en México, de las cuales seis son endémicas al país. Megastigma acarrilloi también representa el primer registro del género para Sinaloa y al norte de la Franja Volcánica Transmexicana.
Resilience Training Web App for National Health Service Keyworkers: Pilot Usability Study
Authors: Burrell Joanna , Baker Felicity , Bennion Matthew Russell
Published: November 2024

Background

It is well established that frontline health care staff are particularly at risk of stress. Resilience is important to help staff to manage daily challenges and to protect against burnout.

Objective

This study aimed to assess the usability and user perceptions of a resilience training web app developed to support health care keyworkers in understanding their own stress response and to help them put into place strategies to manage stress and to build resilience.

Methods

Nurses (n=7) and other keyworkers (n=1), the target users for the resilience training web app, participated in the usability evaluation. Participants completed a pretraining questionnaire capturing basic demographic information and then used the training before completing a posttraining feedback questionnaire exploring the impact and usability of the web app.

Results

From a sample of 8 keyworkers, 6 (75%) rated their current role as “sometimes” stressful. All 8 (100%) keyworkers found the training easy to understand, and 5 of 7 (71%) agreed that the training increased their understanding of both stress and resilience. Further, 6 of 8 (75%) agreed that the resilience model had helped them to understand what resilience is. Many of the keyworkers (6/8, 75%) agreed that the content was relevant to them. Furthermore, 6 of 8 (75%) agreed that they were likely to act to develop their resilience following completion of the training.

Conclusions

This study tested the usability of a web app for resilience training specifically targeting National Health Service keyworkers. This work preceded a larger scale usability study, and it is hoped this study will help guide other studies to develop similar programs in clinical settings.
Efficacy of the mHealth App Intellect in Improving Subclinical Obsessive-Compulsive Disorder in University Students: Randomized Controlled Trial With a 4-Week Follow-Up
Authors: Lee Yoon Li Madeline , Lee Si Min Stephanie , Sündermann Oliver
Published: November 2024

Background

Obsessive-compulsive disorder (OCD) is the third most prevalent mental health disorder in Singapore, with a high degree of burden and large treatment gaps. Self-guided programs on mobile apps are accessible and affordable interventions, with the potential to address subclinical OCD before symptoms escalate.

Objective

This randomized controlled trial aimed to examine the efficacy of a self-guided OCD program on the mobile health (mHealth) app Intellect in improving subclinical OCD and maladaptive perfectionism (MP) as a potential moderator of this predicted relationship.

Methods

University students (N=225) were randomly assigned to an 8-day, self-guided app program on OCD (intervention group) or cooperation (active control). Self-reported measures were obtained at baseline, after the program, and at a 4-week follow-up. The primary outcome measure was OCD symptom severity (Obsessive Compulsive Inventory–Revised [OCI-R]). Baseline MP was assessed as a potential moderator. Depression, anxiety, and stress (Depression Anxiety and Stress Scales-21) were controlled for during statistical analyses.

Results

The final sample included 192 participants. The intervention group reported significantly lower OCI-R scores compared with the active control group after the intervention (partial eta-squared [ηp2]=0.031; P=.02) and at 4-week follow-up (ηp2=0.021; P=.044). A significant, weak positive correlation was found between MP and OCI-R levels at baseline (r=0.28; P<.001). MP was not found to moderate the relationship between condition and OCI-R scores at postintervention (P=.70) and at 4-week follow-up (P=.88).

Conclusions

This study provides evidence that the self-guided OCD program on the Intellect app is effective in reducing subclinical OCD among university students in Singapore. Future studies should include longer follow-up durations and study MP as a moderator in a broader spectrum of OCD symptom severity.

Trial Registration

ClinicalTrials.gov NCT06202677; https://clinicaltrials.gov/study/NCT06202677
The PDC30 Chatbot—Development of a Psychoeducational Resource on Dementia Caregiving Among Family Caregivers: Mixed Methods Acceptability Study
Authors: Cheng Sheung-Tak , Ng Peter H F
Published: November 2024

Background

Providing ongoing support to the increasing number of caregivers as their needs change in the long-term course of dementia is a severe challenge to any health care system. Conversational artificial intelligence (AI) operating 24/7 may help to tackle this problem.

Objective

This study describes the development of a generative AI chatbot—the PDC30 Chatbot—and evaluates its acceptability in a mixed methods study.

Methods

The PDC30 Chatbot was developed using the GPT-4o large language model, with a personality agent to constrain its behavior to provide advice on dementia caregiving based on the Positive Dementia Caregiving in 30 Days Guidebook—a laypeople’s resource based on a validated training manual for dementia caregivers. The PDC30 Chatbot’s responses to 21 common questions were compared with those of ChatGPT and another chatbot (called Chatbot-B) as standards of reference. Chatbot-B was constructed using PDC30 Chatbot’s architecture but replaced the latter’s knowledge base with a collection of authoritative sources, including the World Health Organization’s iSupport, By Us For Us Guides, and 185 web pages or manuals by Alzheimer’s Association, National Institute on Aging, and UK Alzheimer’s Society. In the next phase, to assess the acceptability of the PDC30 Chatbot, 21 family caregivers used the PDC30 Chatbot for two weeks and provided ratings and comments on its acceptability.

Results

Among the three chatbots, ChatGPT’s responses tended to be repetitive and not specific enough. PDC30 Chatbot and Chatbot-B, by virtue of their design, produced highly context-sensitive advice, with the former performing slightly better when the questions conveyed significant psychological distress on the part of the caregiver. In the acceptability study, caregivers found the PDC30 Chatbot highly user-friendly, and its responses quite helpful and easy to understand. They were rather satisfied with it and would strongly recommend it to other caregivers. During the 2-week trial period, the majority used the chatbot more than once per day. Thematic analysis of their written feedback revealed three major themes: helpfulness, accessibility, and improved attitude toward AI.

Conclusions

The PDC30 Chatbot provides quality responses to caregiver questions, which are well-received by caregivers. Conversational AI is a viable approach to improve the support of caregivers.
Where is Average Joe? – #antibioticresistance on Instagram (Preprint)
Authors: Nilsson Elin , Oljans Emma , Nordvall Anna-Carin , Ancillotti Mirko
Published: November 2024

BACKGROUND

Antimicrobial resistance (AMR) is a major global health issue heavily influenced by human behaviour. Effective communication and awareness-raising are crucial in curbing AMR, with social network sites (SNSs) significantly shaping health behaviours. Despite their potential, current analyses of AMR on SNSs have focused mainly on top-down communication initiatives.

OBJECTIVE

This study aims to examine AMR on Instagram, identifying key actors, content themes, and the nature of the communication to understand how AMR is portrayed and perceived.

METHODS

Based on the Sender-Message-Channel-Receiver model, this study used content analysis to review publicly accessible posts on Instagram. The data refer to 24 months, focusing on the hashtag #antibioticresistance. After cleaning the data, 611 posts (10% of the total) were analysed.

RESULTS

Instagram users primarily aimed to inform the public about AMR (81.3%). Content creators were predominantly information drivers or professionals in science and health. Posts frequently featured text-dominated visuals or images of bacteria and lab tests. However, the post of AMR was found to be siloed, with limited engagement beyond specific interest groups. The study highlighted the neutrality and accuracy of the content but noted the challenge of reaching a broader audience.

CONCLUSIONS

While Instagram serves as a platform for accurate and informative AMR communication, the post of it remains confined to niche groups, limiting its broader impact. To enhance engagement, AMR discussions should be integrated into more general interest content, utilise visually compelling formats, and encourage institutional participation and interactive user engagement.
Study on the Emotional Expression and Playing Skills of Mozart's Piano Trio in B Flat Major
Authors: Li Zi
Published: November 2024

This paper focuses on the study of the emotional expression and playing skills of Mozart's piano trio in B flat Major (K.502), aiming to deeply analyze the artistic connotation and performance practice of this classical music masterpiece. Mozart played a role in establishing the "template" in the piano trio music genre. In his creation, the three instruments in the piano trio were truly independent and unique, and the theme of the three voices began to resonate and depend on each other, one after another. He also established the three-movement pattern of piano trio writing and the musical structure of the first and last movements. Through the detailed analysis of the emotional level and performance skills of the work, it provides a more abundant understanding and deductive perspective for music scholars, performers and lovers. The purpose of this study is to systematically explore the ways of emotional expression and the subtleties of performance skills through literature review, music score analysis and field performance experiments. The research process integrates the multi-disciplinary methods of music theory, emotional psychology and performance practice. The conclusion is that Mozart's piano trio in B flat major not only shows his outstanding creative talent, but also provides a broad stage for players to show their personal emotional understanding and technical level.
Empirical Study on the Impact of New-Quality Productivity on Regional Economic Development in China
Authors: Gu Hao
Published: November 2024

New-quality productivity (NQP) reflects the modernization of productivity, characterized by higher technological levels, better quality, and greater efficiency and sustainability. Against the backdrop of technological innovation, NQP plays an increasingly significant role in economic development. Sustained growth of NQP is key to maintaining stable and rapid economic progress. This paper adopts the new-quality productivity index developed by scholar Lu Jiang, Guo Ziang and Wang Yuping, which comprises three dimensions, including innovation capacity, technological research and development, and production efficiency. By using this index, an OLS regression analysis is conducted on the economic development levels of various regions. Through regression analysis, the paper examines the impact of these indicators on regional economic development and provides relevant policy recommendations. The results show with a higher new-quality productivity index tend to have a higher level of economic development. Theoretically, this result further illustrates that new-quality productivity enhances production efficiency through technological innovation and resource optimization, thereby driving economic growth. New-quality productivity not only transcends the traditional factor-driven growth model but also injects stronger innovative momentum and potential for sustainable development into regional economies. On a practical level, improving the level of new-quality productivity can effectively promote the rational allocation of resources, accelerate industrial structure upgrades, and significantly enhance the affluence and vitality of regional economies.
Post-9/11 Analysis of Pakistan-Afghanistan Relations (2001-2021)
Authors: Wu Lichi
Published: November 2024

In the post-9/11 era, Pakistan and Afghanistan share a closely interconnected geopolitical relationship characterized by a mutual prosperity that not only affects the well-being of their populations but also significantly influences regional and global developments. This study employs historical analysis and case studies to examine the bilateral interactions between Pakistan and Afghanistan in the political, security, and economic spheres since the events of 9/11. It finds that their relationship has long remained at a subdued level. The core thesis of this research is that border disputes, terrorism, strategic mistrust, issues with refugees and narcotics, and Indian interference are the principal barriers preventing an improvement in their bilateral ties. Strategic suspicions between Pakistan and Afghanistan have accumulated over many years. The return to power of the Afghan Taliban has once again made terrorism a major impediment in their relationship. In the short term, it remains unlikely that there will be any fundamental change in their bilateral relations.
CHANGES IN BODY COMPOSITION INDUCED BY ORTHODOX RELIGIOUS FASTING ON HIGH SCHOOL STUDENTS
Authors: Herodek Romina , Živković Mladen , Catić-Đorđević Aleksandra
Published: November 2024

Scientific research in recent decades has increasingly focused on changes in body composition influenced by Orthodox religious fasting, which the Church has established before major holidays. The purpose of this study is to provide more information on how body composition parameters changed among high school students who followed the recommendations of Orthodox religious fasting for forty days (during Lent). A sample of twenty-eight students from Holy Cyril and Methodius High School in Niš was analyzed . The average age of all male participants was 17.4 ± 1.2 years. Anthropometric measures were taken both before and after the 40-day fast. The Omron BF 511 device, which provided information on body weight, BMI (body mass index), percentage of body fat, percentage of skeletal muscle, and basal metabolic rate, was used to measure body composition values. The acquired data were subjected to statistical analyses, including ANOVA and MANOVA for repeated measures. The results show a statistically significant difference (p = 0.012) between the initial and final measurements based on the MANOVA analysis. This study indicates that students interested in reducing weight while maintaining their muscle mass could benefit from practicing Orthodox religious fasting for 40 days. Further research is needed to confirm these results and explore the long-term effects of religious fasting and the post-fasting period, particularly for this participant sample.
THE REPRESENTATION OF DIDACTIC MUSICAL GAMES IN THE CURRICULA AND TEXTBOOKS OF MUSICAL CULTURE IN CLASSROOM TEACHING
Authors: Kragović Teodora
Published: November 2024

The representation of didactic musical games in current classroom teaching curricula and Musical Culture textbooks is the focus of this research. Didactic musical games are activities with specific rules and defined educational goal. Through these games, students unconsciously master various melodic and rhythmic concepts while developing their musical abilities. Due to their educational potential, these games are valuable tools for acquiring knowledge and developing skills in the teaching of Musical Culture. In this regard, the goals and tasks of this research are to determine the extent to which didactic musical games are included in the curricula and Musical Culture textbooks. The results indicate that these games are sufficiently represented in relation to the content of the Musical Culture subject. However, it is necessary to more precisely categorize certain musical games, such as singing games, those with instrumental accompaniment, musical dramatizations and didactic musical games. Additionally, we find it essential to provide specific didactic-methodical instructions for implementing these games in the curricula.
Estomatitis alérgica de contacto asociado al consumo de canela en rama
Authors: Gimenez Javier Ignacio , Flück Veronica , Giacco Claudia Analia , Castrillo Ángeles
Published: November 2024

Introducción: La estomatitis de contacto es una reacción intraoral que puede ser provocada por una amplia variedad de agentes. La canela como factor desencadenante es poco frecuente debido al bajo consumo. Sin embargo, la misma se consume en chicles, enjuagues bucales y pasta dental, que son los productos más asociados a la estomatitis alérgica de contacto asociado al consumo de canela. Objetivo: Reportar un caso de estomatitis de contacto asociado al consumo de canela en rama. Presentación del caso: Una paciente de 20 años, con una historia clínica sin incidencias, se presenta relatando dolor ardiente y presencia de manchas en la mucosa oral de más de 3 meses de evolución. También refiere una sensación de ardor y picor intermitente, sin motivo aparente. Luego de una estricta anamnesis la paciente refiere que hace unos años comenzó a mascar canela en forma de rama. La paciente también nos relata que suele colocarla en ambos vestíbulos y a las horas empieza a sentir una sensación descrita como incómoda. Se indicó suspender dicho hábito y durante los controles posteriores se evidenció la desaparición de los signos y síntomas. Conclusión: Una anamnesis meticulosa junto con el examen físico son importantes para establecer un correcto diagnóstico y un adecuado manejo clínico de la estomatitis alérgica de contacto.
PRÁTICAS E DESAFIOS DA AVALIAÇÃO PSICOLÓGICA PARA CIRURGIA BARIÁTRICA: Uma revisão de literatura
Authors: Silva Rosangela Ramos da , Soares Nandra Martins , Mombelli Mônica Augusta
Published: November 2024

The psychological evaluation for bariatric surgery is mandatory, and its conduction by the psychologist must adhere to professional principles and guidelines, as well as specific legislation. Therefore, the study aimed to investigate the process of psychological evaluation for bariatric surgery and, additionally, to identify the psychological factors assessed and the instruments used in the process. This is a bibliographic research with data collection conducted between September and October 2023, in electronic databases such as Lilacs, Scielo, PubMed, and Pepsic, including full-text, open-access scientific articles published from 2018 to 2023. A total of 119 articles were found, of which 14 were selected for analysis. As a result, four categories were identified regarding psychological evaluation in bariatric surgery: 1) Importance of evaluation: involves expectations, support network, stress, and mental health; 2) Relevant psychosocial factors: such as social support and lifestyle; 3) Resources used: tools like BDI–II, BAI, ECAP, BAROS, EFS, IDATE, and LIS-A to assess emotional and cognitive aspects; 4) Challenges: highlight the complexity and the need for a multidisciplinary approach. Difficulties faced by psychologists in conducting these evaluations were also identified, requiring well-structured strategies and practices. Based on these findings, it is crucial that the responsible bodies—such as the Federal Council of Psychology—coordinate efforts, as the implementation of specific documents benefits psychologists and candidates for bariatric surgery by providing clear guidelines and standardizing procedures, making the professional practice more precise, safe, and accessible.
A RELEVÂNCIA DA FORMAÇÃO DO ENFERMEIRO PARA ATUAÇÃO NA CENTRAL DE MATERIAL E ESTERILIZAÇÃO: Uma revisão narrativa
Authors: Sousa Bárbara Maria de Jesus , Silva Luciana de Araújo Mendes , Bicalho Elizaine Aparecida Guimarães
Published: November 2024

The present study aimed to highlight the importance of nurse training to ensure the good performance of the team in the Central Supply and Sterilization Department (CSSD). A narrative theoretical review was conducted, with searches in the BVS (Virtual Health Library) and Scielo (Scientific Electronic Library Online) databases. In addition to articles published in the last ten years, current documents and publications from national health organizations that guide the procedures for sterilizing medical-hospital materials were also considered. The flow of health product processing was described; subsequently, the responsibilities and expected skills of the nurse in the department were specified; finally, important aspects of the professional nurse's training for the role in the CSSD were discussed. The consulted works confirmed the relevance of training and continuous education for nurses as a means of ensuring the effectiveness of health product processing and, consequently, patient safety.
CELPE-BRAS NA VISÃO DA COORDENADORA DE UM CURSO DE PORTUGUÊS PARA CANDIDATOS AO PEC-G
Authors: Barbalho Dionísio Cynthia Israelly , Tavares de Sousa Socorro Cláudia
Published: November 2024

O Certificado de Proficiência em Língua Portuguesa para Estrangeiros (Celpe-Bras) foi adotado como requisito para o ingresso de alunos estrangeiros em Instituições de Ensino Superior (IES) brasileiras através do Programa de Estudantes-Convênio de Graduação (PEC-G). Considerando essa relação entre o exame o convênio, o objetivo do artigo é discutir como o Celpe-Bras atua como um mecanismo de política linguística e quais os seus impactos para os agentes envolvidos em um curso de português para candidatos ao PEC-G, na visão da coordenadora desse curso. O estudo fundamenta-se no conceito de mecanismos de política linguística (SHOHAMY, 2006) e na revisão de literatura que aborda os usos dos testes e suas consequências na sociedade (MENKEN, 2017; SHOHAMY, 2017). A metodologia de pesquisa é qualitativo-interpretativista (LIN, 2015), com geração de dados por meio de entrevista semiestruturada. Os dados foram analisados à luz da concepção sociocognitivo-interacionista de texto e da análise do conteúdo temático, da seleção lexical e da materialidade textual. A discussão apontou que o Celpe-Bras funciona como um mecanismo de política linguística e tem impactos na identidade dos alunos e professores, na agência dos estudantes e nas atribuições profissionais da coordenadora.
DESEMPENHO LINGUÍSTICO INICIAL DE CRIANÇAS COM MICROCEFALIA SECUNDÁRIA A SÍNDROME CONGÊNITA DO ZIKA VÍRUS
Authors: Spinelli-Pessoa Luciane , Alves Giorvan Anderson dos Santos Alves , Vasconcelos Manuela Leitão de Vasconcelos , Neves Tatiana Michelinne Aires Neves , Almeida Larissa Nadjara Alves Almeida , Almeida Pricilla Fernanda Menezes de Almeida
Published: November 2024

INTRODUÇÃO: Desde seu nascimento, a criança é imersa no mundo social, quando a atividade humana é mediada pela linguagem, e, gradativamente, se apropria dos traços de cultura, por meio de sua ação sobre o mundo, das relações com os objetos e com o outro. Crianças com desenvolvimento atípico podem demorar a apresentar comunicação por meio da linguagem oral, caracterizando um desempenho linguístico aquém ao esperado, ou até mesmo não conseguir desenvolvê-la - crianças com a Síndrome Congênita do Zika Vírus (ZIKV) podem passar por ambas situações. OBJETIVO: Descrever o desempenho linguístico inicial de crianças com Microcefalia secundária a Síndrome Congênita do ZIKV. METODOLOGIA: foi realizada avaliação de 10 crianças entre 32 e 45 meses, utilizando a escala Early Language Milestone Scale – ELM, que contém três marcos de linguagem: função auditiva expressiva (AE), função auditiva receptiva (AR) e função visual (V). Esta escala é um instrumento conciso de avaliação de linguagem capaz de detectar alterações nos três primeiros anos de vida. Foi realizada testagem direta (T) da criança; observação incidental do comportamento em questão (O) e/ou o relato dos pais (H). Identificaram-se então, os três itens de sucesso e de fracasso em cada uma das funções. Ao final da testagem, foi identificada a idade de desempenho de cada função (AE, AR e V). Os dados foram tabulados em planilha digital e realizada análise estatística. RESULTADOS: As crianças avaliadas apresentaram escores inferiores ao esperado em todos os itens pesquisados, ressaltando que não se obteve diferenças das habilidades entre elas, sugerindo pouca evolução no desempenho das funções. CONCLUSÃO: As crianças com microcefalia apresentaram desempenho linguístico abaixo do esperado independente da idade, assim como  prejuízos nas áreas auditiva expressiva, auditiva receptiva e visual.
EDITORIAL
Authors: Vital Saulo Roberto de Oliveira
Published: November 2024

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Relação do Ambiente Socioeconômico com o Desempenho Econômico-Financeiro e o Valor de Mercado das Empresas de Capital Aberto do Setor Elétrico Brasileiro
Authors: Fodra Marcelo , Torres Penedo Antônio Sérgio , Silva Pereira Vinícius
Published: November 2024

Objetivo: O objetivo deste artigo foi avaliar o impacto de variáveis macroeconômicas e da crise financeira de 2015-2016 sobre o ROA, ROA-O, ROI e o valor de mercado de empresas brasileiras de capital do setor elétrico brasileiro, no período entre o primeiro trimestre de 2010 até o quarto trimestre de 2020.
Fundamento: A estrutura de capital define as fontes de recursos das empresas e os seus custos exercem impactos sobre a performance financeira e o valor das firmas. A correta seleção das fontes de financiamento pode contribuir com a maximização do lucro e do valor de mercado das empresas.
Método: Foram utilizadas regressões com dados em painel usando efeitos fixos e aleatórios, robustas em relação à heteroscedasticidade.
Resultados: Os resultados mostraram que variáveis macroeconômicas afetaram o desempenho financeiro e o valor de mercado de empresas do setor elétrico de modos diferentes. A taxa de câmbio impactou o ROA, ROI, ROA-O e valor de mercado, ao passo que o crescimento econômico afetou o ROI. Já a taxa de juros produziu efeitos sobre os indicadores de desempenho contábeis, enquanto a dummy de crise repercutiu sobre o ROI e o valor de mercado das empresas.
Contribuições: O trabalho apontou que as variáveis macroeconômicas exerceram influência de formas distintas sobre o desempenho das empresas de capital aberto do setor elétrico brasileiro. Pretendeu contribuir com avanços da literatura sobre o tema relacionado com ações dos gestores causadas por mudanças no ambiente de negócios, causadas por variáveis exógenas.
LEITURAS TEXTOMÉTRICAS EM SEMÂNTICA INTERPRETATIVAPRINCÍPIOS E PERSPECTIVAS DO PROJETO SITTELLE
Authors: Pincemin Bénédicte , Barbosa de Mesquita Batista Maria de Fátima , Mesquita Batista Raquel
Published: November 2024

Por Mª de Fátima B. de M. Batista e Raquel Barbosa de Mesquita Batista, tradução para o português do original francês de PINCEMIN,B In ASEL/UFPB, vol.27,nº 2,ano 46; 2022
SEMÂNTICA INTERPRETATIVA DE FRANCOIS RASTIER
Authors: Batista do Nascimento Flaviano , El Khattab Driss
Published: November 2024

Por Flaviano Batista do Nascimento, tradução do original francês de Driss El Khattab, La sémantique interpretative de François Rastier: cadre epistemologique et repères methodologiques in ASEL, V. 27, nº2, ano 46, 2022
Linguagem Eleitoral
Authors: Schmidt Salvador Marcos Vinicios , Anthero Nunes Vianna dos Santos Flavio , Dos Santos Celio Teodorico
Published: November 2024

A presente pesquisa tem como base a análise semiótica da mudança de comunicação visual do primeiro para o segundo turno da campanha eleitoral de 2018. A mudança de comunicação visual analisada foi da coligação O Povo Feliz de Novo, do candidato a presidente da república Fernando Haddad. Para essa análise foi utilizado um texto pictórico de cada turno do pleito. Assim, foi proposta uma análise do percurso gerativo do sentido, conforme proposição da semiótica greimasiana, visando a identificação de estratégias discursivas e atributos semânticos adotados pelo enunciador na criação de uma imagem valorativa em cada um dos turnos eleitorais e a razão de sua mudança utilizando elementos paratextuais. Esse procedimento metodológico possibilitou revelar diferentes sentidos presentes no texto semiótico e a reafirmação de aspectos de representação de parte e todo no simulacro da candidatura. Sugerem-se novas análises que aprofundem tal discussão a partir da perspectiva semiótica, mas que envolvam também aspectos atrelados a candidatura adversária em um segundo turno.
MULTIMODAL SIMULACRUM AND VISUAL SEMIOSIS
Authors: Trudel Éric
Published: November 2024

This article addresses the problem of mental imagery in the interpretation of iconic signifieds. It examines, with regard tothe iconic sign, François Rastier’s hypothesis that “mental images are constrained (but not entirely determined) by signifieds [in context]” (RASTIER, 1991, p. 242), it being understood that, in Rastier’s systematics, the signified, which belongs to the semioticsphere, is distinguished from the concept, which belongs to the cognitive sphere. More precisely, it is a matter of transposing to visual semiosis the concept of the multimodal simulacrum proposed by Rastier (1991), a kind of eidetic content that would be generated or at least solicited by the semantic structure of the message. In this hypothesis, the interpretation of the iconic sign would cognitively elicit presentations that potentially combine different represented sensory modalities, and also possibly abstract features. The conceptual transposition proposed in this article integrates the results of work in the field of cognitive psychology on mental imagery with Rastier’s proposals.
PARA UMA INDIVIDUAÇÃO DOS MANUSCRITOS POÉTICOS PÒSTUMOS DE CÉSAR VALLEJO
Authors: Batista do Nascimento Flaviano , Barbosa de Mesquita Batista Maria de Fátima , BALLÓN-AGUIRRE Enrique
Published: November 2024

Atualmente há uma deficiência notória nos estudos poéticos: a ausência teórica e metodológica para tornar explícitas as etapas dos rascunhos até chegar à versão impressa de um poema. A partir do corpus de trabalho constituído pela edição diplomática dosmanuscritos e tipos escritos poéticos de César Vallejo, abordaremos esse processo textual, adaptando para este propósito os critérios da «Bricolage intelectual» de C. Lévi-Strauss, os textos autenticados de F. de Saussure e os instrumentos de individuação propostos por G. Simondon. Uma vez descrita a evolução deste corpus, numa etapa posterior da investigação, tentaremos interpretar sua transdução textual a partir da Semântica interpretativa e dos trabalhos posteriores de F. Rastier sobre simbolismo.
RECONSTRUCTION EN PSYCHANALYSE
Authors: Tessier Hélène
Published: November 2024

Este texto trata da teoria de Jean Laplanche e a apresenta como um pensamento de reconstrução em psicanálise. Enfatiza a oposição de Laplanche às correntes pós-modernas e à desconstrução na psicanálise e destaca os elementos de sua teoria que o situam como autor da reconstrução: a reivindicação em favor do caráter científico da metapsicologia e a exigência da busca da verdade na elaboração teórica, epistemologia racionalista e humanista que afirma o caráter histórico e concreto das instâncias psíquicas, oposição tanto às explicações míticas dos conteúdos do inconsciente quanto ao subjetivismo das escolas relacionais, recusa do solipsismo, centralidade do sentido e da interpretação na formação da alma humana e antropologia da transformação.
The Role Equality of Nyai in the Development of Islamic Boarding School (Pesantren)
Authors: Mahbub Moh. , Adnani Kamila
Published: November 2024

The hegemony of the Islamic boarding school (pesantren) has been related to the power of a Kiai. Nowadays, it has been changed by gender equality between Nyai and Kiai in Islamic boarding schools. A Kiai or Nyai can play a role inside or outside of the Islamic boarding school (pesantren). The role of the Kiai as a teacher, caretaker, and owner of the Islamic boarding school (pesantren) is quite dominant. In fact, it is found that a Nyai can also play a role in the development of education, economy, and relations in Islamic boarding schools (pesantren). This study applied a qualitative method with a phenomenological-constructionist approach. Data Collection Techniques were conducted by observation, interview, and documentation. The research results explained that the roles equality of Kiai and Nyai are obtained through a process of adaptation and the existence of space allowing the division of tasks between Kiai and Nyai as the efforts in developing Islamic boarding schools (pesantren).
SOCIAL ACCEPTANCE OF WARIA AS A THIRD GENDER IN THE TOLERANT CITY OF PEMATANG SIANTAR
Authors: Siburian Donny
Published: November 2024

Abstract
Society expected men to behave masculine and play a role like men, and women to behave like women (feminine), who are naturally oriented towards normal sexuality, namely crossing each other. The existence of transgender people who are present in society is perceived as deviant individuals. The purpose of this research is to see the form of community stereotypes towards transgender in Pematangsiantar City, as well as adaptation strategies carried out by transgender people who are accepted (acceptable) in society. This research method is a mix method with a tendency to analyze qualitative data supplemented by quantitative data. The result of this research shows that there are various negative stereotypes attached to transgender people in Pematangsiantar City. Therefore, the various endeavors or strategies of transgender people to adapt or adjust themselves to be accepted (acceptable) as themselves and members of society is a separate effort made by transgender people in the midst of society. This research can be a reference in dealing with social life that exists in the midst of society in dealing with social status as transgender.
Keywords : Transgender; Adaptation; Stereotypes; Social; Acceptability.
THE GENDERED IMPACT OF COVID-19: HOW INDONESIAN WOMEN ARE DISPROPORTIONATELY AFFECTED
Authors: Anabel Iva , Kusumasari Bevaola
Published: November 2024

Gender is not the forefront issue of the COVID-19 pandemic yet lessons from previous outbreaks have suggested that women are disproportionately affected during such crises.  This paper aims to understand the gendered impacts of the pandemic in Indonesia and offer insights into the experiences of women during the pandemic. We collected 10 administrative and survey data from government agencies, international organizations, as well as private organizations to conduct a secondary data analysis on the gendered impact of COVID-19 in Indonesia. Women are found to be bearing the brunt during the COVID-19 pandemic namely employment disruption, the burden of unpaid domestic and care work, heightened risk of gender-based violence, as well as indirect health and wellbeing impacts which includes accessibility to sexual and reproductive health services and stress levels.