bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of Sec61α2 Translocon in Insulin Biosynthesis
Authors: Xu Xiaoxi , Bell Thomas W. , Le Truc , Zhao Ivy , Walker Emily , Wang Yiqing , Xu Ning , Soleimanpour Scott A. , Russ Holger A. , Qi Ling , Tsai Billy , Liu Ming , Arvan Peter
Published: September 2024

Translocational regulation of proinsulin biosynthesis in pancreatic β-cells is unknown, although several studies have reported an important accessory role for the Translocon-Associated Protein complex to assist preproinsulin delivery into the endoplasmic reticulum via the heterotrimeric Sec61 translocon (comprising α, β, and γ subunits). The actual protein-conducting channel is the α-subunit encoded either by Sec61A1 or its paralog Sec61A2. Although the underlying channel selectivity for preproinsulin translocation is unknown, almost all studies of Sec61α to date have focused on Sec61α1. There is currently no evidence to suggest that this gene product plays a major role in proinsulin production, whereas genome-wide association studies indicate linkage of Sec61A2 with diabetes. Here, we report that evolutionary differences in mouse preproinsulin signal peptides affect proinsulin biosynthesis. Moreover, we find that, although some preproinsulin translocation can proceed through Sec61α1, Sec61α2 has a greater impact on proinsulin biosynthesis in pancreatic β-cells. Remarkably, Sec61α2 translocon deficiency exerts a significant inhibitory effect on the biosynthesis of preproinsulin itself, including a disproportionate increase of full-length nascent chain unreleased from ribosomes. This study not only reveals novel translocational regulation of proinsulin biosynthesis but also provides a rationale for genetic evidence suggesting an important role of Sec61α2 in maintaining blood glucose homeostasis.

Article Highlights
Deficiency of the Hemoglobin-Haptoglobin Receptor, CD163, Worsens Insulin Sensitivity in Obese Male Mice
Authors: Schleh Michael W. , Ameka Magdalene K. , Rodriguez Alec S. , Hasty Alyssa H.
Published: September 2024

Excessive iron accumulation in metabolic organs such as the adipose tissue, liver, and skeletal muscle is associated with increased diabetes risk. Tissue-resident macrophages serve multiple roles, including managing inflammatory tone and regulating parenchymal iron homeostasis, thus protecting against metabolic dysfunction upon iron overload. The scavenger receptor CD163 is uniquely present on tissue-resident macrophages and plays a significant role in iron homeostasis by clearing extracellular hemoglobin-haptoglobin complexes, thereby limiting oxidative damage caused by free hemoglobin in metabolic tissues. We show that the absence of CD163 exacerbates glucose intolerance and insulin resistance in male mice with obesity. Additionally, loss of CD163 reduced the expression of iron regulatory genes (Tfr1, Cisd1, Slc40a1) in adipose tissue macrophages and anti-inflammatory (M2-like) bone marrow–derived macrophages (BMDMs). Furthermore, CD163 deficiency mediated a proinflammatory shift and limited hemoglobin scavenging specifically in M2-like BMDMs. To this end, iron buffering was diminished in inguinal white adipose tissue (iWAT) macrophages in vivo, which culminated in iron spillover into adipocytes and CD45+ CD11B− nonmyeloid immune cells in iWAT. These findings show that CD163 on tissue-resident macrophages is critical for their anti-inflammatory and hemoglobin scavenging roles, and its absence results in impaired systemic insulin action in an obese setting.

Article Highlights
Deficiency of the hemoglobin-haptoglobin receptor, CD163, worsens insulin sensitivity in obese male mice
Authors: W. Schleh Michael , Ameka Magdalene , Rodriguez Alec , H. Hasty Alyssa
Published: September 2024

Abstract

Excessive iron accumulation in metabolic organs such as the adipose tissue, liver, and skeletal muscle is associated with increased diabetes risk. Tissue-resident macrophages serve multiple roles including managing inflammatory tone and regulating parachymal iron homeostasis; thus protecting against metabolic dysfunction upon iron overload. The scavenger receptor CD163 is uniquely present on tissue-resident macrophages, and plays a significant role in iron homeostasis by clearing extracellular hemoglobin-haptoglobin complexes, thereby limiting oxidative damage caused by free hemoglobin in metabolic tissues. We show that the absence of CD163 exacerbates glucose intolerance and insulin resistance in male mice with obesity. Additionally, loss of CD163 reduced the expression of iron regulatory genes (Tfr1, Cisd1, Slc40a1) in adipose tissue macrophages and anti-inflammatory (M2-like) bone marrow-derived macrophages (BMDMs). Further, CD163 deficiency mediated a pro-inflammatory shift and limited hemoglobin scavenging specifically in M2-like BMDMs. To this end, iron buffering was diminished in inguinal white adipose tissue (iWAT) macrophages in vivo, which culminated in iron spillover into adipocytes and CD45+CD11B- non-myeloid immune cells in iWAT. These findings show that CD163 on tissue-resident macrophages is critical for their anti-inflammatory and hemoglobin scavenging roles, and its absence results in impaired systemic insulin action in an obese setting.

Article Highlights

· Loss of CD163 mediates a phenotypic switch in M2-like macrophages towards a pro-inflammatory state.

· CD163 is involved in free hemoglobin uptake and catabolism as well as oxidative metabolism, specifically in M2-like macrophages.

· In inguinal white adipose tissue (iWAT) of CD163 defficient mice, macrophage iron is reduced; while concomitantly, adipocyte and other immune cell iron content is increased.

Loss of CD163 provokes glucose intolerance and insulin resistance in obese male mice.
The Budget Impact of Itopride in the Treatment of Functional Dyspepsia in Vietnam
Authors: H* Kim , K Kim , A Bian , QT Duc , TTK Tuong , NTT Cuc
Published: September 2024

Introduction: An estimated 7.8-22.4 million Vietnamese suffer from functional dyspepsia. Prokinetic agents, such as itopride, target this group of patients by enhancing gastric motility through amplifying and coordinating gastrointestinal muscle contractions. Itopride is currently reimbursed in public hospitals at Vietnam Central level hospitals (level 1) and provincial level hospitals (level 2) for the treatment of functional dyspepsia. This study analyses the financial impact of expanding the access of itopride for patients with functional dyspepsia to include level 3 (District level) hospitals + level 4 (Commune health stations) hospitals in Vietnam. Methods: A budget impact model was developed in accordance with the good practice guidelines from the International Society for Pharmacoeconomics and Outcomes Research. The model included both drug costs and healthcare resource utilisation costs. Results: The broadening of the reimbursement of itopride to include level 3+4 hospitals was estimated to provide benefit for between 13.7% (105,923) to 24.6% (89,343) more patients at only 3.3% (VND 41,742M) to 4.2% (VND 74,617M) additional costs over five years. Conclusion: Itopride is deemed to represent great benefit for patients suffering from functional dyspepsia in Vietnam.
evangélicos e o exercício da liberdade religiosa no Brasil
Authors: Silva Clemildo Anacleto da Silva
Published: September 2024

Este texto tem como objetivo responder à seguinte questão: existe perseguição à liberdade de expressão e religiosa dos evangélicos no Brasil? Para respondê-la, este escrito se valeu de uma análise argumentativa e bibliográfica, fundamentada nas seguintes teses: de que, a partir da constituição de 1891, o protestantismo experimentou total liberdade e crescimento numérico de seus fiéis; e de que o argumento da perseguição é uma reação às políticas públicas de combate à discriminação, à intolerância religiosa e à homofobia. Esse tipo de discurso gera engajamento religioso e político das igrejas e dos féis contra o que os evangélicos, de linha pentecostal e neopentecostal, denominam de projeto político cultural. Assim, conclui-se que no Brasil os evangélicos não sofrem perseguição do Estado, nem hostilidade social para exercer sua liberdade de expressão e religiosa.
emergência do neoconservadorismo religioso no espectro político brasileiro
Authors: Ribeiro Antonio Carlos
Published: September 2024

O presente artigo tem por objetivo refletir sobre a constatação da exclusão da modalidade discriminação religiosa do Disque 100 durante a presidência de Jair Messias Bolsonaro. Esse órgão, vinculado à pasta dos direitos humanos, estava à época sob a responsabilidade da ministra Damares Alves. Os dados divulgados nos anos anteriores à gestão bolsonarista apontavam para um quantitativo cujo predomínio de denúncias de violação do direito à liberdade religiosa provinha dos adeptos das religiões afro-brasileiras. Assim, pelo método de pesquisa bibliográfica e qualitativa, abordou-se este assunto sob a categoria neoconservadorismo de viés religioso cujo desdobramento se deu pela ruptura político-institucional que marcava as gestões presidenciais desde o contexto da redemocratização até o governo de Dilma Rousseff. O processo de afirmação dos direitos humanos e constitucionais que vinha sendo engendrado, no qual o Disque 100 seria uma das expressões, foi alterado por uma agenda neoconservadora implementada por Temer e Bolsonaro, deixando o segmento afro-religioso desprovido de um canal de denúncias face aos casos de discriminação religiosa.
Teologia neoliberal
Authors: Witeze Junior Geraldo , Burity Joanildo
Published: September 2024

Este artigo analisa publicações sobre política, economia e sociedade, traduzidas ou escrita originalmente em português, feitas por uma editora amplamente conhecida no campo evangélico brasileiro e sem qualquer tradição nessas áreas, as Edições Vida Nova. O trabalho visa a compreender tanto o contexto dessa produção e difusão literária quanto a lógica argumentativa das obras publicadas, situando duplamente o material analisado: no plano da conjuntura internacional e nacional; no plano dos debates a respeito da política evangélica contemporânea. Os resultados apontam para uma vinculação progressiva da editora ao neoliberalismo e ao neoconservadorismo, com a consequente rejeição do campo progressista como incompatível ao cristianismo.
RELEVÂNCIA DA GESTÃO ESCOLAR DEMOCRÁTICA PARA A INCLUSÃO DE ALUNOS COM DEFICIÊNCIA
Authors: Lima da Silva Canja Antonia Edivânia Lima da Silva Canja
Published: September 2024

A presente pesquisa teve como objetivo analisar as contribuições da gestão participativa e democrática para a inclusão de alunos com deficiência. Para tanto, realizou-se uma revisão sistemática nas plataformas Scielo e Google Acadêmico, sob a orientação das diretrizes do PRISMA. Foram selecionados somente artigos científicos brasileiros e publicados entre os anos de 2019 e 2023. Diante da análise dos estudos que abordaram a gestão democrática e a inclusão de alunos com deficiência, emerge uma compreensão acerca da relevância da gestão escolar democrática e participativa para superar desafios e promover uma educação inclusiva e de qualidade. A abordagem participativa, que engloba ativamente toda a comunidade escolar, é destacada como um elemento crucial para o êxito desse empreendimento. A proposta de mudança de paradigma não se limita a abandonar o papel tradicional do diretor, mas envolve adotar uma postura de gestor de ideias, mediador de discussões e construtor de consensos. Essa transformação é respaldada por um gestor descentralizado, cujas ações são pautadas pelo desejo coletivo da comunidade, estabelecendo princípios através de um processo inclusivo que incorpora discussões e participação coletiva. Os resultados positivos, evidenciados nas conclusões dos estudos, refletem comunidades escolares ativas e engajadas, indicando uma abordagem democrática e inclusiva. O exercício de cidadania promovido por essa gestão participativa destaca o diálogo, a mediação de conflitos e a construção de decisões coletivas como elementos-chave. Adicionalmente, a formação em serviço, a colaboração efetiva com os professores, a elaboração participativa do Projeto Político Pedagógico e a desconstrução de concepções ultrapassadas são recomendadas como práticas essenciais para a gestão democrática e inclusiva.
REVISÃO SISTEMÁTICA DE RELATOS DE EXPERIÊNCIA SOBRE O ENSINO DE RESENHA ACADÊMICA
Authors: Trajano Oliveira Rebeca , Da Silva Elizabeth Maria
Published: September 2024

Neste trabalho, objetiva-se mapear objetos de ensino contemplados na exploração do gênero resenha acadêmica socializada em relatos de experiência publicados em periódicos brasileiros nos últimos dez anos e identificar abordagens de ensino de escrita acadêmica subjacentes a esse mapeamento. Trata-se de uma revisão sistemática realizada no Google Acadêmico e no Portal de Periódicos da CAPES, a partir dos descritores “ensino do gênero resenha acadêmica”, “resenha acadêmica” e “ensino de escrita acadêmica”. Os resultados indicam a predominância de objetos relacionados à estrutura composicional do gênero resenha, sinalizando indícios da abordagem da socialização acadêmica. Visibilizar o ensino explícito de gêneros acadêmicos é relevante, visto que enriquece as experiências de docentes e discentes.
DISCURSO MIDIÁTICO
Authors: Lira Aldenizia Moreira Guimaraes , Soares Thiago Barbosa , Boucher Damião Francisco
Published: September 2024

Este artigo tem objetiva examinar efeitos de verdade nos discursos midiáticos. Especificamente, o ethos discursivo da verdade em um vídeo da jornalista Rachel Sheherazade. Assim, utiliza-se o referencial teórico-metodológico da Análise do Discurso, sobretudo as noções de ethos discursivo, interdiscurso, processamento parafrástico e polissêmico e formações imaginárias. O corpus analisado, consiste em um vídeo reproduzido em 3 de março de 2011 pela emissora de TV Tambaú, sediada em João Pessoa. Para atingir o objetivo inicialmente proposto, examina-se, além dos efeitos de sentidos, a posição discursiva do enunciador e seus deslocamentos, observando os efeitos da linguagem tanto em sua estabilização quanto em sua deriva semântica. Nesse batimento, examina-se também, no discurso midiático da referida enunciadora, como os efeitos de verdade são construídos a partir das memórias como materialidades simbólicas da historicidade. Ao final desse percurso, reflete-se acerca do funcionamento dos efeitos de verdade, bem como sua afetação no circuito social.
PRÁTICAS DE ESCRILEITURA DE FAKE NEWS NO UNIVERSO DIGITAL
Authors: Franco Kátia Regina , Capistrano de Souza Júnior Rivaldo
Published: September 2024

Este artigo discute como elementos linguísticos e informáticos dos tecnodiscursos cofuncionam para a construção dos sentidos de fake news publicada no X, e reflete sobre quais habilidades são acionadas para leitura e escrita de textos nativos do ambiente digital. À luz da Linguística Textual em interface com a Análise do Discurso Digital, adotou-se a metodologia de análise amostral ecossistêmica (PAVEAU, 2021) da textualidade nativa digital. As fake news parecem ter encontrado um ambiente propício de produção e disseminação no universo digital, usando ferramentas e recursos da plataforma em cofuncionamento com elementos linguageiros para a construção dos possíveis sentidos pretendidos pelo enunciador e realizados pelos escrileitores.
Expressividades
Authors: Branco Sérgio Dias
Published: September 2024

Este artigo procura refletir sobre os conceitos de entretenimento, engajamento, e poética aplicados à arte cinematográfica e inscreve este conjunto de reflexões no âmbito da autenticidade estética do cinema. A discussão estrutura-se em torno da questão da autonomia da arte, com um foco nas relações entre estética cinematográfica e a autenticidade, e será conduzida em torno das formas expressivas e a artisticidade no cinema, evitando a dicotomia e optando pela dialética no modo de pensamento.
Cinema, alucinação e linguagem onírica
Authors: Rodrigues Marcelo Gonçalves
Published: September 2024

Apresenta-se neste artigo a tentativa de enunciar o entrelaçamento familiar entre a produção fílmica, a formação dos sonhos, e a linguagem onírica. A aproximação desses objetos como cinema, linguagem e composição imagética dos sonhos é bem pontuada nos estados estéticos cinematográficos do diretor, David Lynch. Assim, como dialógica complementar acerca da formação dos sonhos, do cinema e da imagem no seio de nossa cultura capitalista, percorremos também pela via da tradição filosófica da Teoria Crítica da Sociedade para a qual os dispositivos tecnológicos em tela funcionam como descarga de estimulação fora do normal impossível de ser absorvida pelo sistema nervoso. Semelhante aos pesadelos recorrentes dos soldados de guerra tal estimulação tecnológica tem igual propósito, direcionar o usuário à compulsão de repetição agitada, viciante e rápida para poder mitigar o choque traumático por meio da hiperinflação de imagens.
poética das máscaras à beleza do gesto
Authors: Rodrigues Leonardo
Published: September 2024

Trata-se de propor uma reflexão a respeito do estatuto filosófico das questões instauradas por Holy Motors, longa-metragem de 2012 dirigido pelo cineasta francês Leos Carax. Para tanto, nortearemos nosso horizonte de análise a partir de dois operadores centrais que se depreendem da complexa trama do filme: a poética das máscaras, de um lado, e a beleza do gesto, de outro. Tais questões nos ajudariam a conjecturar um vasto conjunto de problemas que o filme de Carax tangencia, tais como um questionamento sobre a consistência das noções de “sujeito” e de “identidade”, uma compreensão da variabilidade estrutural das máscaras como mecanismo de produção de sentido, uma mediação sobre o tempo da repetição como modalidade de afirmação no mundo e a possiblidade de extração de uma poética das condutas e de uma beleza involuntária através da expressão de sujeitos psicologicamente desconstituídos.
Reflexões filosóficas de uma enfermeira sobre o cuidado na finitude, a partir das aulas de Filosofia da Saúde no Mestrado Profissional em Ensino em Ciências das Saúde
Authors: Freire Caroline , Cândido Viviane Cristina
Published: September 2024

Este ensaio incorpora reflexões filosóficas sobre a finitude como condição humana e a relevância da reflexão sobre esse tema na assistência à saúde, a partir do aprendizado e das experiências vivenciadas por uma enfermeira, na disciplina eletiva de Filosofia da Saúde, ministrada no Mestrado Profissional em Ensino em Ciências da Saúde, que tinha como base, o estudo de textos literários es filosóficos e discussões que consideravam os textos, os relatos pessoais de experiências e a troca entre as participantes. Neste contexto, foi explorada a intersecção entre a filosofia da saúde, a ética e a bioética e a prática clínica, destacando a importância da reflexão sobre a vida, o sofrimento, a morte e a finitude humana no contexto da Medicina como ciência e da prática dos profissionais de saúde que dela resulta em cuidado e assistência em saúde.
Multidisciplinaridade e multiprofissionalidade em saúde como relação
Authors: Carvalho Fongaro Nars Clarissa , Cândido Viviane Cristina
Published: September 2024

Esse ensaio parte da discussão apresentada pelas autoras na I Jornada Internacional de Filosofia e Medicina, sobre a relação com o outro na área da saúde, que considerava a potência do encontro entre o Eu e o Tu, teorizada por Martin Buber (1878-1965); avançando para uma proposta de aprofundamento no tema, com foco no pensamento de Franz Rosenzweig (1886-1929), para quem somos e nos conhecemos por meio de nossas relações, em um determinado tempo e enquanto experiência. Assim, pretende-se detalhar a abordagem sobre o encontro como relação com o outro, de uma perspectiva que avance da filosofia dialógica para uma filosofia experimentada. Para fomentar esse debate, faremos uma aproximação com a multiprofissionalidade, prática fundamental na saúde e importante para o campo, que pressupõe uma multidisciplinaridade, evidenciando que as ligações profissionais são ainda baseadas em conhecimentos, mas podem apontar para a multiplicidade característica da área, rumo a um encontro entre profissionais.
Discussion of results in original research: Rhetorical moves and their implementation
Authors: Tikhonova E. V.
Published: September 2024

The Discussion section in the manuscript of an original empirical study is the most creative and challenging part to construct. Incorrect discussion of results in many manuscripts submitted to scientific journals often leads to their rejection, even if the results themselves hold potential significance for the scientific community. The absence or poor quality of interpretation of results by the authors can negatively affect the overall perception of the study by readers. The most complete functional implementation of the Discussion section is achieved by adhering to its rhetorical structure. The purpose of this article is to analyze the functions, content, and rhetorical organization of the Discussion section of an original empirical study. The main function of the Discussion section is to interpret and explain the significance of the study’s results, highlight the current state of knowledge on the stated problem, and explain new aspects arising from the results obtained. Authors also need to specify the external validity of the data and demonstrate how these data can be generalized. The most effective way to implement the stated function is by relying on a model of the interdisciplinary rhetorical structure of the Discussion section, which can be modified according to the conventions of the discipline and the characteristics of the specific study. Depending on the study’s logic, certain rhetorical moves or steps of the structure may be omitted; however, a more comprehensive list of moves provides a more thorough interpretation of the results. Understanding the content of each move and its steps allows authors to present all necessary information regarding the obtained results in a way that ensures their objective and unambiguous perception by readers.
Retrosternal Goiter with Acromegaly – An Airway Challenge
Authors: Deshpande Mukti , Waghalkar Pallavi , Furia Jhanvi , Patel RD , Mulkalwar Alhad , Kate Vikram
Published: September 2024

Background: Patients with acromegaly may present with a goiter. Moreover, patients with acromegaly are more prone to develop severe airway obstruction and breathing difficulties during induction therapy because of enlargement of the tongue, hypertrophy of soft tissue, and mandibular prognathism as a sequela of the underlying acromegaly. Here, we have described successful airway management in patients with difficult airways with retrosternal goiter and acromegaly. Case Presentation: A 29-year-old female presented to our tertiary care hospital with complaints of swelling in the anterior aspect of the neck, headache, amenorrhea, and a change in voice, which she noticed progressively increasing in the last ten years. Examination revealed thyroid enlargement of about 8 cm with regular margins and a smooth surface. To ensure airway safety, airway management was prepared preoperatively, including high-flow nasal oxygen on standby and ear-nose and throat surgeons on standby with small and long ventilating bronchoscopes for tracheostomy if required. A pre-extubation check scope was done, and it showed mobile bilateral vocal cords. A cuff leak test was performed, and the result was negative. The patient was successfully extubated and kept in the recovery room for seven days. Conclusion: A careful preoperative assessment and appropriate planning are necessary during intubation and extubation in such patients to avoid life-threatening complications caused by the difficult airway.
Reinterpretation of Hunnic Title Ku-t’u孤涂
Authors: Şengül Fatih
Published: September 2024

We don’t have much information about the language of Asian Huns who played one of the most important roles in both Turkic and world history and occupy a remerkable place in Asian history. On the other hand, we have been familiar with all existing data pertaining to their language thanks to Chinese annals. Chinese annals mention some words which belong to their language. One part of those words constitutes the captions belonging to Hunnic ruling class. One of those captions is Ku-t’u’ meaning “son” which is given by the Huns for their rulers. The mentioned caption has been tried to be explained with different meanings. Some researchers evaluate the true meaning of this caption as “son”and link this with the words which match up with it semantically and phonetically while others aim at clarifying it with the namings which are evocative of the meaning of majesty. In this paper it will be shown that the mentioned caption is related to a belief system belonging to Turks and Mongols. The main topic of this paper revolves around explanation of the mentioned caption on the base of a belief in Turks and Mongols.
Senyawa Non-aromatik Herba Centella asiatica menggunakan Metode Baru melalui Karbon Aktif, dan Analisis Farmakologi Jejaring pada Luka Bakar
Authors: Awaluddin Rizki , Mustaqim Rafli Mulkan , Arbain Dayar , Hayati Farida , Khaerunnisa Siti
Published: September 2024

Prevalensi luka bakar masih menjadi perhatian kaitannya dengan perubahan fisik pasca luka bakar yakni contractures, hypertrophic scar dan keloid yang menurunkan fungsi, kualitas hidup dan estetika kulit. Herba pegagan (Centella asiatica) melalui senyawa triterpen telah dikenal untuk mempercepat luka bakar. Namun, sifat senyawa triterpen yang polar identik dengan keberadaan klorofil dan senyawa lainnya yang sulit dipisahkan. Masih adanya kontroversi terkait protein yang berperan dalam kesembuhan luka bakar membutuhkan kajian untuk menentukan protein potensial. Penelitian ini bertujuan untuk mengeksplorasi metode baru pada ekstraksi herba pegagan menggunakan karbon aktif serja kajian farmakologi jejaring untuk menentukan protein potensial. Herba pegagan diekstraksi menggunakan metode maserasi pada pelarut metanol dan dilanjutkan dengan penambahan karbon aktif. Hasil purifikasi diidentifikasi menggunakan KLT dengan fase gerak kloroform: asam asetat glasial: metanol: akuades (60:32:12:8 v/v) dan pereaksi semprot anisaldehid-asam sulfat. Kajian farmakologi jejaring dilakukan secara in silico untuk mengkaji interaksi protein-protein dan senyawa-protein berkaitan dengan luka bakar. Hasil skrining fitokimia menunjukkan keberadaan asaticoside pada ekstrak terpurifikasi dan maserat dengan nilai Rf yang relatif identik. Senyawa non aromatik berperan dalam mempercepat kesembuhan luka bakar dengan mempengaruhi protein IL1β, IL6, MAPK8, PTGS2, NOX4, IFN-γ, NFKB1, TGFβ1, MMP13, dan TNF.
De sustantivo a pronombre relativo: la historia de men en el zapoteco de San Bartolo Yautepec
Authors: Covarrubias Acosta Adela
Published: September 2024

En este artículo se estudia el desarrollo histórico del sustantivo *kw-enneʔ  ‘persona’ desde el protozapoteco hasta el zapoteco de San Bartolo Yautepec, una variante de zapoteco sureño. Esta forma se gramaticalizó como un pronombre de tercera persona de respeto =mé, como primer elemento en algunos compuestos nominales que comienzan con men- y como el pronombre relativo men. Se estudian las formas cognadas del pronombre relativo men en otras variantes de zapoteco cisyautepequeño en donde encontramos evidencia de cómo se dio el reanálisis de sustantivo hipernónimo a pronombre relativo y se proponen 3 etapas de gramaticalización para estos pronombres relativos. Se propone que el pronombre relativo del zapoteco de San Bartolo Yautepec se encuentra en la segunda etapa en la que ha sufrido pérdida de rasgos de animacidad. Se argumenta que este reanálisis de sustantivos hiperónimos a pronombres relativos es un canal de gramaticalización de pronombres relativos común en las lenguas zapotecas de la Sierra Sur y se proporcionan ejemplos de cinco lenguas zapotecas.
Policy analysis of green bonds in Indonesia: Strategies for achieving sustainable development
Authors: Saa Septinus
Published: September 2024

The use of green bonds as a financial instrument to support sustainable development has become a major focus in Indonesia. However, the success of green bond implementation not only depends on market willingness but also on public policies that support and regulate its use. Therefore, this research aims to analyze the impact of public policies on the use of green bonds in Indonesia and how these policies can influence sustainable development. Public policy theory and sustainable development theory are the basis of analysis in this research. Public policy theory is used to understand how public policies are formed, implemented, and evaluated. Meanwhile, sustainable development theory is used to evaluate the impact of public policies on sustainable development. This research uses a qualitative approach with public policy analysis as the main method. Data are collected from various sources, including policy documents, government reports, and interviews with relevant stakeholders. The analysis results show that public policies have a significant impact on the use of green bonds in Indonesia. These policies cover various aspects, such as regulation, incentives, and government support. Additionally, these policies also influence how green bonds are used to support sustainable development in Indonesia. In order to promote sustainable development, it is important for the Indonesian government to continue developing and strengthening public policies that support the use of green bonds. This will help improve the success.
Research into intergenerational differences among Chinese female tourists consuming Thai cosmetics
Authors: Ma Juan , Walsh John
Published: September 2024

Consumers, particularly women, pursue beauty and health in order to uphold their image within society, which has contributed to consistent demand for cosmetics. The cosmetics market, driven by globalization and cultural exchange, sees Thai cosmetics gaining popularity among Chinese women. There has been a significant rise in the popularity of Thai cosmetics, known for their natural ingredients and innovative formulations. With a growing interest in cross-cultural consumer behaviour, particularly in the context of skincare and make-up products, understanding how different age groups perceive and choose Thai cosmetics is crucial for effective marketing strategies. The main issue is the development of consumer preferences over time among Chinese women who have only recently been given the opportunity to choose among many brands. This qualitative study explores the intergenerational differences in Chinese female consumers’ preferences for Thai cosmetics, aiming to uncover rich insights into their perceptions, attitudes, and behaviours. The target population is female Chinese who have visited Thailand and purchased or used Thai-branded cosmetics. Key themes emerge regarding the perception of product efficacy, the cultural authenticity and the role of digital media and trends in influencing product choices. Findings highlight nuanced generational preferences, with older cohorts emphasizing trust and familiarity with established brands, while younger cohorts prioritize innovation, sustainability, and personalized beauty experiences. These insights provide valuable implications for marketers seeking to tailor strategies and product offerings to engage effectively diverse generational segments within the competitive cosmetics market.
Analysis of the Processes in the Welding Arc during Additive Manufacturing
Authors: Petkov V. , Tashev P. , Dyakova V.
Published: September 2024

Experimental studies of arc burning have been carried out with a view to use it for wire arc additive manufacturing processes. The values of the welding arc current and voltage were recorded and the records were analyzed. The average duration of the short circuits and its root mean square deviation and normalized root mean square deviation were determined. Investigation of the macro- and microstructure of the 3D printed sample show that it is uniform along its entire height.
Controlling Dilution in Multilayer Welding for Additive Manufacturing
Authors: Emami M. , Elahi S.H.
Published: September 2024

Functionally graded material is a type of material characterized by gradual variations in the chemical composition and structure over volume. Dilution is a major concern in producing such materials produced using welding techniques. In this paper, the effects of the number and thickness of weld overlay layers on the dilution were systematically investigated for two common wire arc additive manufacturing processes. Gas metal arc welding and flux-cored arc welding processes were used to clad plain carbon steel substrate by 410 stainless steel and Stellite 6, respectively. Welding speed was varied to create weld layers with a thickness of 2 mm to 8 mm. The results showed that the weld thickness had the main effect on the dilution. Regarding the number and arrangement of the thin or thick weld layers, no direct effects on the dilution were observed. Consequently, by controlling the thickness of the weld overlay, the changes in the chemical composition in each weld layer could be justified.
The Effect of Fiber on the Green Strength and Buildability of High-Strength 3D Printing Concrete
Authors: Shahib Al Bari M. , Ekaputri Januarti J.
Published: September 2024

This paper presents four parameters in 3D Printing Concrete (3DPC) in the fresh state. Flowability, extrudability, open time, and buildability. In addition, this paper also introduces a new method to obtain the green strength of fresh concrete. The high-strength concrete mixture was used as a base mix design. The water to binder ratio and admixture were tuned to obtain the 3DPC that satisfied those four parameters. The 3DPC mix design used cement, silica fume, and reactive powder as a binder with a ratio of 3:1:1. The ratio of sand and binder was 0.9. The water to binder ratio (w/b) was 0.14 with the addition of a superplasticizer and accelerator. To increase the buildability, polyvinyl alcohol (PVA) fiber was added by 0.2% of concrete volume. It had a 30 mm slump, 110 mm flow, 1.1 SRF, 85 minutes of open time, and 7 KPa green strength in 75 minutes. This mix design was able to be printed into 40 layers of 100×400 mm cylinder.
Microstructure Characterisation, Hardness, and Corrosion Behaviour of Nickel-Silicon Carbide Electrodeposition Coating with The Influence of Ultrasonic Agitation
Authors: Loganathan A. , Kamdi Z. , Ainuddin A.R. , Husin R. , Ibrahim A. , Salleh M.A.A.M.
Published: September 2024

This study is about the electrodeposition of Ni-SiC composite coatings at various ultrasonic agitation temperatures (50, 55, and 60°C). The coatings were characterised by a scanning electron microscope (SEM) and energy dispersive spectroscopy (EDS). Vickers microhardness test and immersion test were used to determine the hardness and corrosion behaviour of the composite coating respectively. The immersion test was conducted in 0.5M sulphuric acid to analyse the coating corrosion rate. The results demonstrate that increasing the ultrasonic agitation temperature increase the corrosion resistance of the composite coating. Furthermore, the hardness of the Ni-SiC shows higher hardness values at the highest agitation temperature, 60°C. This shows that Ni-SiC composite coating sample S.60 had the best hardness and corrosion behaviour.
A Study of Mechanical and Wear Behavior of SiC-CeO2 Reinforced Al7075 Hot Rolled Hybrid Composites
Authors: Ravikumar M. , Naik R. , Suresh R. , Chethana K.Y.
Published: September 2024

Fabrication of aluminium (Al) composites by stir casting process is an effective method for fabrication of better quality of Metal Matrix Composites (MMCs). Stir casting technique is one of the most commonly accepted techniques. In this research work, Al7075 / SiC+CeO2 hybrid MMCs have been fabricated with varying wt.% of SiC (2%, 4%, 6% and 8%) particulates and constant 5% of CeO2 particulates. The ascast alloy and hybrid composite were hot rolled at a temperature of 500°C. Whereas, both the ascast and hot rolled hybrid composite was subjected to micro-structural, mechanical and wear tests. Optical microscope analysis revealed uniform dispersal of hard particles with in the base matrix in case of both of ascast and hot rolled composites. Hot rolled MMCs showed enhancement of 22.64% of hardness when compared with ascast alloy with increasing reinforcement of 0-6 wt.% of SiC content. Tensile strength increases by 28.24% for hot rolled composites when compared to the as cast and other hybrid composites. Reduction of wear loss by 54.38% for hot rolled composites when compared to the as cast and other hybrid composites. A tensile and wear fractography result shows the internal fractured structure which was analysed using a SEM analysis
In-Silico Investigation of Photovoltaic Performance of MgXS3 (X = Ti and Zr) Chalcogenide Perovskites Compounds
Authors: Olopade M.A. , Oyebola O.O. , Balogun R.O. , Adewoyin A.D. , Adegboyega A.B.
Published: September 2024

First-principles density functional formulation was used to explore the electronic and optical properties of magnesium chalcogenides sulfides, MgXS3 (X = Ti and Zr), which compose of magnesium titanium sulfide, MgTiS3, and magnesium zirconium sulfide, MgZrS3. The lattice parameter calculations for MgZrS3 yielded 9.19 Å, a bulk modulus of 170.6 GPa, and an equilibrium volume of 423.03 Å3. In contrast, MgTiS3 yielded 9.27 Å, a bulk modulus of 251.3 GPa, and an equilibrium volume of 117.06 3 Å3. The computation gave a direct bandgap value for MgTiS3 and MgZrS3 of 1.1 eV and 1.3 eV, respectively. The dielectric constants of 38 and 32 were observed for the imaginary and real values for energy equivalents of 0.7 eV and 1.35 eV. The determined dielectric constants and energy values of the perovskite compounds were 70 and 1.35 eV respectively with their point of intersection also at this bandgap value. The efficiency of the compounds was calculated using the spectroscopic limited maximum efficiency (SLME) in order to ascertain their output as absorber materials. The findings show that MgZrS3 had a higher efficiency value of 32.54% and MgTiS3 with 29.45%. These compounds’ computed properties point to the possibility of creating inexpensive, non-toxic absorber layer materials for use in solar cell development and other electronic applications.
A Novel Real-Time Assessment of the Wear Analysis of Cu-Ni-Sn Hybrid Composite for Multifunctional Applications Strengthened by Nano B4C
Authors: Lenin Haiter A. , Murugan Srinivasan , Arul Sujin Jose , Vasanthi S. Mary
Published: September 2024

The hybrid composite is fabricated by powder metallurgy technique. The addition of ceramic reinforcements to the matrix phase helps in attaining tribological properties. Initially, the metal powders are prepared by atomization and reduction process. To reduce oxidation of pure metals, electrolytic process is carried out. The crushing, milling and sintering process are carried after atomization to obtain fine grain sized particles; these are then characterized using Scanning Electron Microscope (SEM), X-Ray Diffractometer (XRD). The obtained particles are then blended and compacted to attain better hardness and wear resistant of the materials. The hybrid composites prepared for the analysis by reinforcing 15%Ni-8%Sn-4%B4C to the matrix phase Cu. The pin-on-disc method is incorporated to study the wear rate, hardness and co-efficient of friction. By varying the contribution parameters such as load 10 N-25 N, sliding distance 400 mm-1000 mm and sliding speed, the matrix phase materials exhibited rigorous wear, whereas the reinforced hybrid composite (Cu-15%Ni-8%Sn-4%B4C) provide good strength and wear resistant and also reduced volume loss of 25×10–5cm3and 110×10–5 cm3 for 10 N load with 400 mm and 1000 mm sliding distance even at sintering temperature of 900°C. The microstructure and morphology of the worn surface is analyzed using Scanning Electron Microscopy images. The sintered density of the hybrid composite is less due to reduced number of pores and so material defect is also condensed.
Effect of Aging Parameters of EN AW-7021 Aluminium Alloys on Stress Corrosion Cracking
Authors: Boczkal S. , Węgrzyn M. , Szymański W. , Bem J. , Wala K. , Płonka B. , Leśniak D. , Nowak M.
Published: September 2024

The main assumption of the conducted research was the selection of appropriate heat treatment parameters to obtain the best possible resistance to stress corrosion cracking (SCC) and the highest strength properties of the extruded profiles. The work selected the temperature and time of one- and two-stage treatment of the EN AW-7021 alloy based on aging curves. Tests carried out for samples after aging at 135°C for 24 h and two-stage aging at 90°C/8 h + 135°C/8 h revealed the highest resistance to SCC. The 7021 alloy, after heat treatment at 90°C/8 h + 135°C/16 h, reached the highest tensile strength of 534MPa. Transmission electron microscopy (TEM) observations showed slight differences in the finely dispersed nucleoids between the selected parameters of the artificial aging process.
Unconventional Elements in the Gating System and Their Influence on the Melt Flow and Casting Quality
Authors: Brůna M. , Galčík M. , Medňanský M. , Kasińska J.
Published: September 2024

The naturally pressurized gating system appears to be an appropriate solution for reoxidation reduction, but this type of gating system can result in supercritical melt velocity. The paper is focused on the determination of the unconventional elements effect in the gating system on the melt velocity and melt flow and their influence on the mechanical properties and microstructure. In experimental works was observed the influence of dimensioned gate, foam filters with 10 and 30 ppi density, trident gate and combination of trident gate and vortex element. Melt velocity was observed by simulation software and via velocity measurement by contact method in the mold during casting. Melt flow was analyzed by simulation software and water model experiment. Experimental casts have been made for the purpose of evaluating mechanical properties and microstructure determination. The best results were achieved by 30 ppi foam filter.
Effect of Tin (Sn) Addition on the Corrosion Behavior of Hydroxyapatite (HAP) Coated Mg/MgSn Alloys using Different Coating Methods
Authors: Salleh S.H.M. , Malek R.A. , Zaidi N.H.A. , Abdullah S.S.C. , Khantachawana A. , Błoch K.
Published: September 2024

This study investigates the effect of tin (Sn) addition on the corrosion behavior of hydroxyapatite (HAP) coated Magnesium (Mg) /MgSn alloys by using two different coating methods. Mg/Mg alloys have gained significant attention in recent years due to their lightweight, high strength, and potential for use in a wide range of industrial applications. However, their corrosion properties during cathodic reactions with abundant hydrogen evolution have limited their widespread use, particularly in biomedical applications. In this study, pure Mg, Mg2Sn, Mg3Sn, Mg4Sn, and Mg5Sn alloys were prepared by powder metallurgy method. Then samples were coated by two different methods, dip-coating and electro-deposition. Potentiodynamic polarization and hydrogen evolution reaction analysis were performed to evaluate the corrosion rate and the hydrogen volume released from the alloys. The results indicate that the addition of Sn does not significantly increase the corrosion resistance of MgSn alloys. However, the current density and hydrogen evolution of the alloys are apparently improved after the coating process. The better corrosion resistance was observed for the Mg with higher composition, which are Mg4Sn and Mg5Sn. Overall, the study demonstrates that coating HAP onto the surface of MgSn alloys is able to improve their corrosion behavior and suppress the hydrogen evolution rate (HER) of the MgSn alloys. This improvement in other ways will increase their potential for industrial applications specifically in biomedical applications.
Influence of TiO2 Alloying Percentage on the Morphology of APS-deposited Coatings from Cr2O3 Powders
Authors: Cristisor D. , Chicet D.-L. , Istrate B. , Stescu C. , Munteanu C.
Published: September 2024

In this paper we studied how alloying with different percentages of TiO2 influences the microstructure of Cr2O3 base matrix coatings deposited by plasma spray (APS). Thus, five different types of coatings were made, in which the percentage of TiO2 varied as 0%, 10%, 20%, 30% and 40%. The samples were analysed morphologically both on the surface and in cross-section using direct observation and electron microscopy (SEM). It was observed that none of the TiO2-containing coatings is a simple blend of distinct phases, but are coatings with a specific layered lamellar structure, with coarser and smooth areas, depending on the Ti wt.% presence. All the coatings analysed show micro cracks, porosities and inhomogeneous structure, but with a higher density directly proportional to the percentage of TiO2 in the composition of the coated powder.
Investigation on the Microstructure, Microhardness and Tensile Strength of Stir-Casted A713-TiB2 Composites
Authors: Rangrej S. , Pandya S. , Menghani J.
Published: September 2024

A parametric experimental investigation has been conducted to investigate effects of stir casting process parameters on recently developed A713-TiB2 composites. The manufacturing process involved varying the stirring time (5, 10, and 15 minutes) and speed of stirring (500, 600 & 700 rpm). The microstructure and mechanical properties of the manufactured composites were evaluated by analyzing the effects of the varying stirring speeds and times. The analysis techniques used include optical microscopy (OM), scanning electron microscopy (SEM), micro-hardness and tensile testing. Grain size analysis of the as-cast MMCs revealed that coarser grain structure was observed at lower stirring time and lower speed. Finer grain structure was achieved by increasing stirring time and speed. Microhardness and tensile strength was observed to be affected by both stirring speed and stirring time, as demonstrated by the test results. The uniform dispersion was attained when stirring was done at 600 rpm for 10 minutes. Further increase in stirring speed and stirring time leads to the reduction in microhardness and tensile strength. In the present study, the relationship between the microstructure and mechanical properties of the A713-TiB2 composite and the processing parameters such as stirring speed and stirring time have been investigated.
Why FETs detect a THz signal at a frequency far beyond their amplifying capabilities
Authors: Marczewski Jacek , Zaborowski Michał , Tomaszewski Daniel , Zagrajek Przemysław , Pałka Norbert
Published: September 2024

Field-effect transistors (FETs) are efficient detectors of THz radiation. Despite over three decades of research, controversy still exists regarding the detection mechanism. The article attempts to solve this problem systemically. Existing approaches to modeling THz detection are critically reviewed, including plasmonic, resistive mixing, hot carrier and thermal models. Limitations and inconsistencies of the first two approaches, along with some classical physics principles and experiments conducted, were identified. These include the facts that some models were formulated independently of material relaxation time constraints, and the plasmonic approach does not take into account the conditions for the formation of surface plasmon-polarons and does not describe the case of p-type devices (hole plasmons have never been experimentally recorded). Relevant measurements and theoretical considerations illustrate the inadequacy of these models. As a result of this analysis, thermoelectric models are expected to explain THz sensing by FETs.