bluuebunny/crossref_metadata_2025 huggingface dataset:
Artificial Intelligence–Based Radiotherapy Contouring and Planning to Improve Global Access to Cancer Care
Authors: Court Laurence E. , Aggarwal Ajay , Jhingran Anuja , Naidoo Komeela , Netherton Tucker , Olanrewaju Adenike , Peterson Christine , Parkes Jeannette , Simonds Hannah , Trauernicht Christoph , Zhang Lifei , Beadle Beth M. ,   Radiation Planning Assistant Consortium, Ahmad Shareen , Anderson David , Baghwala Arjig , Chan Karen , Das Prajnan , Edwards Albert , Elbanna May , Elhalawani Hesham , Elsayed Medhat , Ewongwo Agnes , Fakie Nazia , Fuller C. David , Garden Adam , Gove Matt , Guerrero-Urbano Teresa , Kaittany Njeri , Khan Mishal , Langer Joshua , Leeig Percy , Lee Becky , Lee Anna , Lee Belinda , Leech Michelle , Li Ben , Lichter Katie , Lin Lilie , Lin Stacy , Lombe Dorothy , Mallick Indranil , Maroongroge Sean , Martin Rachael , McGinnis Gwendolyn , Mezera Megan , Mohammedsaid Mustefa , Nguyen Son , Nuanjing Jenny , Phillips Tony , Prajapati Surendra , Punt Lydia , Reed Valerie , Roniger Dominique , Shaitelman Simona , Sherriff Alicia , Shiao Jay , Skinner Heath , Susan Ashely , Sutton Jordan , Syed Hamza , Thang Sandy , Thompson Juanita , Walker Gary , Wetter Julie , White Ingrid , Xu Melody , Yousif Yousif , Zhu Simeng
Published: March 2024

PURPOSE

Increased automation has been identified as one approach to improving global cancer care. The Radiation Planning Assistant (RPA) is a web-based tool offering automated radiotherapy (RT) contouring and planning to low-resource clinics. In this study, the RPA workflow and clinical acceptability were assessed by physicians around the world.

METHODS

The RPA output for 75 cases was reviewed by at least three physicians; 31 radiation oncologists at 16 institutions in six countries on five continents reviewed RPA contours and plans for clinical acceptability using a 5-point Likert scale.

RESULTS

For cervical cancer, RPA plans using bony landmarks were scored as usable as-is in 81% (with minor edits 93%); using soft tissue contours, plans were scored as usable as-is in 79% (with minor edits 96%). For postmastectomy breast cancer, RPA plans were scored as usable as-is in 44% (with minor edits 91%). For whole-brain treatment, RPA plans were scored as usable as-is in 67% (with minor edits 99%). For head/neck cancer, the normal tissue autocontours were acceptable as-is in 89% (with minor edits 97%). The clinical target volumes (CTVs) were acceptable as-is in 40% (with minor edits 93%). The volumetric-modulated arc therapy (VMAT) plans were acceptable as-is in 87% (with minor edits 96%). For cervical cancer, the normal tissue autocontours were acceptable as-is in 92% (with minor edits 99%). The CTVs for cervical cancer were scored as acceptable as-is in 83% (with minor edits 92%). The VMAT plans for cervical cancer were acceptable as-is in 99% (with minor edits 100%).

CONCLUSION

The RPA, a web-based tool designed to improve access to high-quality RT in low-resource settings, has high rates of clinical acceptability by practicing clinicians around the world. It has significant potential for successful implementation in low-resource clinics.
Real-World Treatment Patterns and Clinical Outcomes After Platinum-Doublet Chemotherapy and Immunotherapy in Metastatic Non–Small Cell Lung Cancer: A Multiregional Chart Review in the United States, Europe, and Japan
Authors: Leal Ticiana A. , Dasgupta Anandaroop , Latremouille-Viau Dominick , Rossi Carmine , Rai Pragya , Barlesi Fabrice , Liu Stephen V.
Published: March 2024

PURPOSE

To characterize treatment patterns and real-world clinical outcomes of patients with metastatic non–small cell lung cancer (mNSCLC) who developed progression on an anti–PD-1/anti–PD-L1, herein referred to as anti–PD-(L)1, and platinum-doublet chemotherapy.

METHODS

Eligible oncologists/pulmonologists in the United States, Europe (France, Germany, and United Kingdom), and Japan completed electronic case report forms for patients with mNSCLC (no evidence of EGFR/ALK/ROS1 alterations). Eligible patients had disease progression on/after an anti–PD-(L)1 and platinum-doublet chemotherapy (received concurrently or sequentially), initiated a subsequent line of therapy (LOT) between 2017 and 2021, and had an Eastern Cooperative Oncology Group (ECOG) performance status 0-2 at this subsequent LOT initiation (index date). Overall survival (OS), time to treatment discontinuation (TTD), and real-world progression-free survival (rwPFS) after index were assessed using Kaplan-Meier analysis.

RESULTS

Overall, 160 physicians (academic, 54.4%; community, 45.6%) provided deidentified data from 487 patient charts (United States, 141; Europe, 218; Japan, 128; at mNSCLC diagnosis: median age 66 years, 64.7% male, 81.3% nonsquamous, 86.2% de novo mNSCLC; at line of interest initiation: 86.0% ECOG 0-1, 39.6% liver metastases, 18.9% brain metastases, 79.1% smoking history). The most common treatment regimens upon progression after anti–PD-(L)1/platinum-doublet chemotherapy were nonplatinum chemotherapy (50.5%), nonplatinum chemotherapy plus vascular endothelial growth factor receptor inhibitor (12.9%), and platinum-doublet chemotherapy (6.6%). Median OS was 8.8 months (squamous, 7.8 months; nonsquamous, 9.5 months). Median TTD was 4.3 months (squamous, 4.1 months; nonsquamous, 4.3 months). Median rwPFS was 5.1 months (squamous, 4.6 months; nonsquamous, 5.4 months).

CONCLUSION

In this multiregional, real-world analysis of pooled patient chart data, patients with mNSCLC who had disease progression after anti–PD-(L)1/platinum-doublet chemotherapy had poor clinical outcomes with various treatment regimens, demonstrating an unmet clinical need for effective options after failure on anti–PD-(L)1 and platinum-doublet chemotherapy treatments.
Prognostic and Predictive Value of Immunoscore in Stage III Colorectal Cancer: Pooled Analysis of Cases From the SCOT and IDEA-HORG Studies
Authors: Domingo Enric , Kelly Caroline , Hay Jennifer , Sansom Owen , Maka Noori , Oien Karin , Iveson Tim , Saunders Mark , Kerr Rachel , Tomlinson Ian , Edwards Joanne , Harkin Andrea , Nowak Marta , Koelzer Viktor , Easton Alistair , Boukovinas Ioannis , Moustou Eleni , Messaritakis Ippokratis , Chondrozoumaki Maria , Karagianni Michaela , Pagès Franck , Arnoux Fanny , Lautard Christelle , Lovera Yoann , Boquet Isabelle , Catteau Aurélie , Galon Jérôme ,   TransSCOT Consortium, Souglakos Ioannis , Church David N. , Church David , Domingo Enric , Edwards Joanne , Glimelius Bengt , Gogenur Ismail , Harkin Andrea , Hay Jen , Iveson Timothy , Jaeger Emma , Kelly Caroline , Kerr Rachel , Maka Noori , Morgan Hannah , Oien Karin , Orange Clare , Palles Claire , Roxburgh Campbell , Sansom Owen , Saunders Mark , Tomlinson Ian
Published: March 2024

PURPOSE

Immunoscore (IS) is prognostic in stage III colorectal cancer (CRC) and may predict benefit of duration (6 v 3 months) of adjuvant infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX) chemotherapy. We sought to determine IS prognostic and predictive value in stage-III CRC treated with adjuvant FOLFOX or oral capecitabine and infusional oxaliplatin (CAPOX) in the SCOT and IDEA-HORG trials.

METHODS

Three thousand sixty-one cases had tumor samples, of which 2,643 (1,792 CAPOX) were eligible for IS testing. Predefined cutoffs (IS-Low and IS-High) were used to classify cases into two groups for analysis of disease-free survival (3-year DFS) and multivariable-adjusted hazard ratios (mvHRs) by Cox regression.

RESULTS

IS was determined in 2,608 (99.5%) eligible cases, with 877 (33.7%) samples classified as IS-Low. IS-Low tumors were more commonly high-risk (T4 and/or N2; 52.9% IS-Low v 42.2% IS-High; P < .001) and in younger patients ( P = .024). Patients with IS-Low tumors had significantly shorter DFS in the CAPOX, FOLFOX, and combined cohorts (mvHR, 1.52 [95% CI, 1.28 to 1.82]; mvHR, 1.58 [95% CI, 1.22 to 2.04]; and mvHR, 1.55 [95% CI, 1.34 to 1.79], respectively; P < .001 all comparisons), regardless of sex, BMI, clinical risk group, tumor location, treatment duration, or chemotherapy regimen. IS prognostic value was greater in younger (≤65 years) than older (>65 years) patients in the CAPOX cohort (mvHR, 1.92 [95% CI, 1.50 to 2.46] v 1.28 [95% CI, 1.01 to 1.63], PINTERACTION = .026), and in DNA mismatch repair proficient than deficient mismatch repair disease (mvHR, 1.68 [95% CI, 1.41 to 2.00] v 0.67 [95% CI, 0.30 to 1.49], PINTERACTION = .03), although these exploratory analyses were uncorrected for multiple testing. Adding IS to a model containing all clinical variables significantly improved prediction of DFS (likelihood ratio test, P < .001) regardless of MMR status.

CONCLUSION

IS is prognostic in stage III CRC treated with FOLFOX or CAPOX, including within clinically relevant tumor subgroups. Possible variation in IS prognostic value by age and MMR status, and prediction of benefit from extended adjuvant therapy merit validation.
Efficacy of Poly(ADP-ribose) Polymerase Inhibitors by Individual Genes in Homologous Recombination Repair Gene-Mutated Metastatic Castration-Resistant Prostate Cancer: A US Food and Drug Administration Pooled Analysis
Authors: Fallah Jaleh , Xu Jianjin , Weinstock Chana , Gao Xin , Heiss Brian L. , Maguire William F. , Chang Elaine , Agrawal Sundeep , Tang Shenghui , Amiri-Kordestani Laleh , Pazdur Richard , Kluetz Paul G. , Suzman Daniel L.
Published: March 2024

PURPOSE

We performed a pooled analysis of multiple trials of poly(ADP-ribose) polymerase inhibitors (PARPi) in metastatic castration-resistant prostate cancer (mCRPC) to investigate the efficacy of PARPi in each individual homologous recombination repair (HRR) mutated (m) gene.

PATIENTS AND METHODS

We pooled patient-level data from trials of PARPi in mCRPC that reported mutation status in individual HRR genes. Any HRR gene with available data across all the randomized trials of PARPi in first-line mCRPC was selected. The hazard ratios (HRs; 95% CI) for radiographic progression-free survival (rPFS; by blinded independent review) and overall survival (OS) of a PARPi plus an androgen receptor pathway inhibitor (ARPI) relative to placebo plus an ARPI in the pool of three randomized trials in first-line mCRPC were calculated using Kaplan-Meier estimates and a Cox proportional hazards model.

RESULTS

In ATMm (N = 268), rPFS HR was 1.05 (0.74 to 1.49) and OS HR was 1.18 (0.82 to 1.71). In BRCA1m (N = 64), rPFS HR was 0.51 (0.23 to 1.1) and OS HR was 0.74 (0.34 to 1.61). In BRCA2m (N = 422), rPFS HR was 0.31 (0.23 to 0.42) and OS HR was 0.66 (0.49 to 0.89). In CDK12m (N = 164), rPFS HR was 0.50 (0.32 to 0.80) and OS HR was 0.63 (0.39 to 0.99). In CHEK2m (N = 172), rPFS HR was 1.06 (0.67 to 1.66) and OS HR was 1.53 (0.95 to 2.46). In PALB2m (N = 41) rPFS HR was 0.52 (0.23 to 1.17) and OS HR was 0.78 (0.34 to 1.8).

CONCLUSION

In this pooled analysis, benefit from PARPi appeared greatest for patients with BRCA1m, BRCA2m, CDK12m, and PALB2m. Given limitations of this exploratory analysis, the apparent lack of benefit from PARPi in patients with CHEK2m or ATMm should be further explored in future clinical trials.
Comprehensive Analysis Identifies Variability in PI3K Pathway Alterations in Triple-Negative Breast Cancer Subtypes
Authors: Basho Reva K. , Zhao Li , White Jason B. , Huo Lei , Bassett Roland L. , Mittendorf Elizabeth A. , Thompson Alastair , Litton Jennifer K. , Ueno Naoto , Arun Banu , Lim Bora , Valero Vicente , Tripathy Debu , Zhang Jianhua , Adrada Beatriz E. , Santiago Lumarie , Ravenberg Elizabeth , Seth Sahil , Yam Clinton , Moulder Stacy L. , Damodaran Senthil
Published: March 2024

PURPOSE

The PI3K pathway is frequently altered in triple-negative breast cancer (TNBC). Limited cell line and human data suggest that TNBC tumors characterized as mesenchymal (M) and luminal androgen receptor (LAR) subtypes have increased incidence of alterations in the PI3K pathway. The impact of PI3K pathway alterations across TNBC subtypes is poorly understood.

METHODS

Pretreatment tumor was evaluated from operable TNBC patients enrolled on a clinical trial of neoadjuvant therapy (NAT; A Robust TNBC Evaluation fraMework to Improve Survival [ClinicalTrials.gov identifier: NCT02276443 ]). Tumors were characterized into seven TNBC subtypes per Pietenpol criteria (basal-like 1, basal-like 2, immunomodulatory, M, mesenchymal stem-like, LAR, and unstable). Using whole-exome sequencing, RNA sequencing, and immunohistochemistry for PTEN, alterations were identified in 32 genes known to activate the PI3K pathway. Alterations in each subtype were associated with pathologic response to NAT.

RESULTS

In evaluated patients (N = 177), there was a significant difference in the incidence of PI3K pathway alterations across TNBC subtypes ( P < .01). The highest incidence of alterations was seen in LAR (81%), BL2 (79%), and M (62%) subtypes. The odds ratio for pathologic complete response (pCR) in the presence of PIK3CA mutation, PTEN mutation, and/or PTEN loss was highest in the LAR subtype and lowest in the M subtype, but these findings did not reach statistical significance. Presence of PIK3CA mutation was associated with pCR in the LAR subtype ( P = .02).

CONCLUSION

PI3K pathway alteration can affect response to NAT in TNBC, and targeted agents may improve outcomes, particularly in patients with M and LAR TNBC.
Bayesian Forecasting of Mortality Rates for Small Areas Using Spatiotemporal Models
Authors: Goes Julius
Published: March 2024

Estimation and prediction of subnational mortality rates for small areas are essential planning tools for studying health inequalities. Standard methods do not perform well when data are noisy, a typical behavior of subnational datasets. Thus, reliable estimates are difficult to obtain. I present a Bayesian hierarchical model framework for prediction of mortality rates at a small or subnational level. By combining ideas from demography and epidemiology, the classical mortality modeling framework is extended to include an additional spatial component capturing regional heterogeneity. Information is pooled across neighboring regions and smoothed over time and age. To make predictions more robust and address the issue of model selection, a Bayesian version of stacking is considered using leave-future-out validation. I apply this method to forecast mortality rates for 96 regions in Bavaria, Germany, disaggregated by age and sex. Uncertainty surrounding the forecasts is provided in terms of prediction intervals. Using posterior predictive checks, I show that the models capture the essential features and are suitable to forecast the data at hand. On held-out data, my predictions outperform those of standard models lacking a regional component.
Separating Scarring Effect and Selection of Early-Life Exposures With Genetic Data
Authors: Furuya Shiro , Zheng Fengyi , Lu Qiongshi , Fletcher Jason M.
Published: March 2024

Causal life course research examining consequences of early-life exposures has largely relied on associations between early-life environments and later-life outcomes using exogenous environmental shocks. Nonetheless, even with (quasi-)randomized early-life exposures, these associations may reflect not only causation (“scarring”) but also selection (i.e., which members are included in data assessing later life). Investigating this selection and its impacts on estimated effects of early-life conditions has, however, often been ignored because of a lack of pre-exposure data. This study proposes an approach for assessing and correcting selection, separately from scarring, using genetic measurements. Because genetic measurements are determined at the time of conception, any associations with early-life exposures should be interpreted as selection. Using data from the UK Biobank, we find that in utero exposure to a higher area-level infant mortality rate is associated with genetic predispositions correlated with better educational attainment and health. These findings point to the direction and magnitude of selection from this exposure. Corrections for this selection in examinations of effects of exposure on later educational attainment suggest underestimates of 26–74%; effects on other life course outcomes also vary across selection correction methods.
Impact of Procedure Time on First Pass Effect in Mechanical Thrombectomy for Anterior Circulation Acute Ischemic Stroke
Authors: Koo Andrew B. , Reeves Benjamin C. , Renedo Daniela , Maier Ilko L. , Al Kasab Sami , Jabbour Pascal , Kim Joon-Tae , Wolfe Stacey Q. , Rai Ansaar , Starke Robert M. , Psychogios Marios-Nikos , Shaban Amir , Arthur Adam , Yoshimura Shinichi , Cuellar Hugo , Grossberg Jonathan A. , Alawieh Ali , Romano Daniele G. , Tanweer Omar , Mascitelli Justin , Fragata Isabel , Polifka Adam , Osbun Joshua , Crosa Roberto , Park Min S. , Levitt Michael R. , Brinjikji Waleed , Moss Mark , Dumont Travis , Williamson Richard , Navia Pedro , Kan Peter , Spiotta Alejandro M. , Sheth Kevin N. , de Havenon Adam , Matouk Charles C.
Published: March 2024

BACKGROUND AND OBJECTIVES:

First pass effect (FPE) is a metric increasingly used to determine the success of mechanical thrombectomy (MT) procedures. However, few studies have investigated whether the duration of the procedure can modify the clinical benefit of FPE. We sought to determine whether FPE after MT for anterior circulation large vessel occlusion acute ischemic stroke is modified by procedural time (PT).

METHODS:

A multicenter, international data set was retrospectively analyzed for anterior circulation large vessel occlusion acute ischemic stroke treated by MT who achieved excellent reperfusion (thrombolysis in cerebral infarction 2c/3). The primary outcome was good functional outcome defined by 90-day modified Rankin scale scores of 0–2. The primary study exposure was first pass success (FPS, 1 pass vs ≥2 passes) and the secondary exposure was PT. We fit-adjusted logistic regression models and used marginal effects to assess the interaction between PT (≤30 vs >30 minutes) and FPS, adjusting for potential confounders including time from stroke presentation.

RESULTS:

A total of 1310 patients had excellent reperfusion. These patients were divided into 2 cohorts based on PT: ≤30 minutes (777 patients, 59.3%) and >30 minutes (533 patients, 40.7%). Good functional outcome was observed in 658 patients (50.2%). The interaction term between FPS and PT was significant (P = .018). Individuals with FPS in ≤30 minutes had 11.5% higher adjusted predicted probability of good outcome compared with those who required ≥2 passes (58.2% vs 46.7%, P = .001). However, there was no significant difference in the adjusted predicted probability of good outcome in individuals with PT >30 minutes. This relationship appeared identical in models with PT treated as a continuous variable.

CONCLUSION:

FPE is modified by PT, with the added clinical benefit lost in longer procedures greater than 30 minutes. A comprehensive metric for MT procedures, namely, FPE30, may better represent the ideal of fast, complete reperfusion with a single pass of a thrombectomy device.
Clearance rates of sand-burrowed and laterally pressed unburrowed Pismo clam Tivela stultorum (Mawe 1823) in a laboratory open-flow system
Authors: Zepeda Enrique , Garcia-Esquivel Zaul , González-Gómez Marco A. , Díaz Fernando , Castellanos-Martinez Sheila
Published: March 2024

Pismo clam extraction is currently banned in Mexico to help the recovery of natural populations. Thus, the primary objective of this study was to gain insight on its basic biology and husbandry protocols. Growth and clearance rate (CR) of sand-burrowed and sediment-free, laterally pressed adult Pismo clams were quantified in the laboratory as a function of burrowing condition, flow, temperature, and microalgal concentration using open-flow chambers. After 40 days, clams remained healthy regardless of burrowing condition and showed a hyperbolic CR response pattern to increased flow, with CR directly proportional to flows lower than 1000 ml min−1. Maximal asymptotic CR values (300 to 400 ml min−1 org−1) were observed from 1000 to 2000 ml min−1. No significant CR differences were observed between burrowed and laterally pressed clams, yet microalgal concentration effects were detected, with constant maximal CRs of ∼250 ml min−1 in the range of 50 to 200 cells µl−1 and decline at higher concentrations. Maintenance protocols of laterally pressed organisms were validated in the laboratory with both weight and CR data. To our knowledge, this is the first study providing whole-body physiological data translated into effective husbandry protocols for Pismo clams. This approach represents a fresh perspective to traditional research areas, opening the possibility for continued experimentation under controlled conditions.
Prebosphoric occurrence of Korean rockfish, Sebastes schlegelii Hilgendorf, 1880 in southwestern Black Sea with notes on its morphometry and dispersal potential
Authors: Uzer Uğur , Karakulak Firdes Saadet , Kabasakal Hakan
Published: March 2024

On 21 December 2023 one specimen of Sebastes schlegelii Hilgendorf, 1880 have been captured by means of a commercial bottom trawler towed at a depth of 30 m off Şile coast. Following its first occurrence in Turkish Black Sea waters off Giresun coast on 6 March 2023, it has recently reported from the Sea of Marmara (Gulf of İzmit) on 7 January 2024, exhibiting a noteworthy dispersal speed which required less than one year to migrate across nearly a 1,000 km. Therefore, the dispersal and potential interactions with indigenous species of this invasive teleostean along theTurkish coast should be monitored carefully. In the present article, authors provide full morphometric and meristic characters of S. schlegelii, as well.
Controlling in an industrial enterprise
Authors: Karminskiy Aleksandr , Fal'ko Sergey , Tihvinskiy Valeriy , Ivanova Nadezhda , Malikova Sof'ya
Published: March 2024

The methodological and practical foundations of the development and implementation of a controlling system in organizations are considered. The main functions and tasks of operational and strategic controlling are outlined. The functions, tasks and tools of controlling the functional areas of the enterprise are revealed. Special attention is paid to the information support of controlling. The experience of setting up a controlling system at domestic enterprises of various sectors of the national economy is presented for the first time.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For students, teachers and postgraduates of economic universities and faculties, as well as for businessmen seeking to build effective management systems based on modern management methods.
Geopolitics. In 2 vols .
Authors: Muhaev Rashid
Published: March 2024

What does the world expect as a result of the geopolitical transformation associated with the transition from a unipolar to a multipolar world order? Will this result in a just and secure world order in which there will be no hegemon, the chosen and the outcasts? What will the geostructure of the first half of the XXI century represent? The answers to these questions can be found in volume 1 of this textbook.
Geopolitics is considered as a science and a set of practices of global positioning of states in the context of the totality of factors determining their strategic potential in the modern world. A systematic presentation of geopolitics as a scientific discipline is presented, the evolution of geopolitical ideas and concepts is traced, and the current state of geopolitics is revealed. The practices and technology of the formation of geopolitical spatial models underlying the world political order at different stages of the historical development of mankind are considered. Special attention is paid to the analysis of the current phase of the geopolitical development of the world system associated with the formation of a multipolar world order, possible geostrategies of the leading countries of the world and regions in the context of the confrontation between the global North led by the United States and the global South led by Russia and China are identified.
For students and postgraduates studying in the fields of 41.03.04 "Political Science", 41.03.05 "International Relations", 38.03.04 "State and Municipal Administration", 41.03.02 "Regional Studies".
University education in modern conditions: a psychologist's view
Authors: Suhova Elena
Published: March 2024

The monograph presents a study of various aspects of university education in modern socio-economic conditions, based on standardized tests and targeted questionnaires developed by the author. Recommendations are given on reserves for improving the effectiveness of education at the university, pedagogical interaction.
It is recommended for teachers of universities, institutions of secondary vocational education, students, undergraduates, postgraduates.
Monitoring the sustainable development of forest ecosystems in a changing climate
Authors: Kolomyc Erland
Published: March 2024

The monograph presents a working concept of the theory and methods of terrestrial geosystem monitoring of forests. For the first time, the complete triad of monitoring is considered in its classical definition: "observation (assessment of the state) - control (forecasting) - management (adaptation, feedback, regulation)". The patterns of local and regional response of forests to global climate change are described. The entire array of scientific and methodological developments is systematized in such a way as to reveal the content of geo-ecological monitoring using multidimensional system analysis enriched with empirical and statistical models of basic and predicted states, geo (eco) systems as integral dynamic formations. Forecasts of changes in the biological cycle, including forest productivity, are given. Analytical and cartographic models of functional stability of forest ecosystems are presented. Quantitative forecast estimates of the local and regional regulation of the carbon cycle by forest ecosystems in the context of modern global warming are presented.
For students, postgraduates and young scientists studying landscape ecology, environmental modeling and forecasting.
From theism to Egotheism: the genesis of the relationship between man and God
Authors: Kazakov Evgeniy
Published: March 2024

The monograph is devoted to the study of one of the "eternal" philosophical problems — the relationship between man and God. The main stages of the genesis of these relations are investigated, special emphasis is placed on the analysis of its current stage. The research is the result of many years of work by the author, reflected in the books: "The Genesis of mental life"; "Soul: the metaphysics of self-determination"; "Homo nudes"; "The Heartbreaker".
It is addressed to teachers, graduate students and students who are interested in the metaphysics of human existence.
Personnel management of a hotel company. New ways and solutions
Authors: Klyuchevskaya Irina
Published: March 2024

The following topical issues are considered in the monograph: the personnel management system at a hotel enterprise — the use of new recruitment methods and work to attract young professionals to the hotel industry, motivation management and stimulation of the work activity of the staff of a hotel enterprise based on the consideration of the gender characteristics of employees and the current state of the industry, the development of the organization's personnel — a new concept and practice with taking into account the peculiarities of the hotel business in modern conditions, problems and solutions to conflict situations arising in the work of modern hotels.
For a wide range of professionals, the professional education system, enterprises of the real sector of the economy and entrepreneurs.
The role of legistics in normative work (foreign experience)
Authors: Pashencev Dmitriy , Pilipenko Anatoliy , Zaloilo Maksim , Treschetenkova Natal'ya , Leschenkov Feliks
Published: March 2024

The state of modern law depends on its system—forming element — the law, the role and quality of which can be improved to a certain extent with the help of legistics, a new scientific direction and practical activities for the preparation of texts of normative acts, primarily draft laws.
It is this stage of normative work that largely determines the future of the law, its effectiveness and efficiency. Giving this work a clear and consistent methodological basis is the main task of legistics. The purpose of this scientific and practical manual is to highlight its main parameters and identify positive experiences that can be used in domestic lawmaking.
For representatives of legislative and executive authorities, specialists in the field of legislative work, teachers and researchers, as well as for students and postgraduates of law schools and faculties.
Zamek Kapitulny w Kwidzynie w średniowieczu. Architektura i technika budowy w świetle badań archeologiczno-architektonicznych
Authors: Wasik Bogusz
Published: March 2024

W artykule przedstawiono rekonstrukcję architektury zamku kapituły pomezańskiej w średniowieczu oraz techniki jego budowy w oparciu o ostatnio przeprowadzone badania. Jak dotąd najlepiej rozpoznaną częścią zamku pozostaje zamek wysoki (kasztel), choć nie ma pełnej zgodności np. co do funkcji poszczególnych wnętrz. Najsłabiej rozpoznane pozostaje przedzamcze, którego rekonstrukcję oparto na nowożytnej ikonografii. Ostatnie badania archeologiczno-architektoniczne na zamku wysokim były pierwszymi, które umożliwiły odtworzenie przekształceń terenu i uzupełniły wiedzę o technice budowy zamku.
JAIME PIMENTEL EN EL CONTEXTO ARTÍSTICO MALAGUEÑO CONTEMPORÁNEO. DESDE LAS INFLUENCIAS NÓRDICAS DE GRIMDALEN, VIGELAND Y MILLES A SU IMPRONTA MEDITERRÁNEA.
Authors: Garandillas Cordero Adolfo
Published: March 2024

En este artículo se aborda un tema inédito sobre el escultor Jaime Pimentel. Se analiza concretamente su papel en el ambiente artístico malagueño y los nexos e interrelaciones con sus protagonistas más destacados durante los más de sesenta años de su trayectoria profesional. Se tratan las temáticas de las esculturas, los procesos creativos, el uso de fórmulas y la concepción de las obras de Pimentel en parangón con los escultores que, de la misma o de distintas generaciones, conviven en el periodo cronológico de su trayectoria profesional. Finalmente, y tras los posibles diálogos de su producción con la de los artistas más populares de Málaga, se estudia la presencia de su Maestra Anne Grimdalen y de los nórdicos Vigeland y Milles como fuente recurrente de su escultura.
Między potępieniem a (n)ostalgią
Authors: Gelles Katarzyna
Published: March 2024

BETWEEN CONDEMNATION AND (N)OSTALGIA: ON THE POLITISATION OF THE LEGACY OF GDR IN REUNIFIED GERMANY
Reunified Germany emerged on the map of Europe in 1990. At first, settling an account with the communist Germany proceeded in a simplified way – everything about them seemed evil. Over time, this judgement became less biased and more comprehensive. At the beginning of the 21st century, the “trend for the East”, which was called Ostalgie, prevailed. From that point forward, dealing with their past balances between a sentimental journey to the time of the German Democratic Republic and a harsh assessment of that reality. Until this day, modern Germany constitutes two unequal parts, as the polls confirm. They continue to be divided by a mental barrier — an invisible ‘wall in people’s heads’, and many residents of the new lands still feel foreign in their own country. Their dissatisfaction is consciously and effectively exploited by the populist Alternative for Germany party. How the East German heritage becomes an instrument of political influence is the leading question of this article. The sources, mainly German, consist primarily of subject literature, documents, statistical reports and analysis of public opinion research centres, as well as comments of experts and press.
Od ofiary do światowego lidera. Estonia po cyberatakach z 2007 roku
Authors: Warchoł Agnieszka
Published: March 2024

FROM VICTIM TO LEADER – ESTONIA AFTER THE 2007 CYBERATTACKS
In the spring of 2007, Estonia became the target of co-ordinated cyberattacks. The attacks were part of a wider political conflict between Estonia and Russia over the relocation of a Soviet-era monument in Tallinn. The aim of this article is to present the effects of the cyberattacks on Estonian cybersecurity. The article consists of several parts. The first deals with the main causes of the conflict. In the second part, the author presents information about the direct results of the cyberattacks on Estonia. The last part presents strategic, legal and organisational changes in Estonian cybersecurity. At present, Estonia is one of the most developed nations regarding the ubiquitous use of information and communication technology in all aspects of state functioning. The study used the following research methods: historical method, comparative analysis, literature analysis and criticism, source analysis and criticism, and case study.
Liberalconstitutional Backsliding of Democracy and the Threat of the Pandemic
Authors: Pietrzyk-Reeves Dorota , Górnisiewicz Arkadiusz , Szlachta Bogdan
Published: March 2024

In this article we argue that what is called today a ‘democratic backsliding’ or de-consolidation should be analysed, at least in some cases, as a liberal-constitutional backsliding for which the pandemic of Covid-19 adds a new impetus and creates the situation where violation of constitutionality of law might become a norm. In our theoretical considerations, we propose to examine this problem from two interconnected perspectives: the tension between the liberal and the democratic components of liberal democracy, often overlooked by the dominant democratic theory, and constitutionalism as the major safeguard of individual rights and liberties that limits democratic sovereignty, or the will of the people expressed by democratic representation. To better understand the nature of the current crisis of liberal-constitutional backsliding, we refer to Carl Schmitt’s concept of ‘the administrative state’ where the dominant legal act is an administrative decree which does not require constitutional legitimacy or even the guarantee that it expresses the will of the majority. Our empirical considerations focus on the case of the liberal-constitutional backsliding in Poland exacerbated by the pandemic, which provides a good illustration of how the tensions within the liberal-democratic model itself can be used to justify democratic sovereignty as the only source of political legitimacy.
Students’ perception of digital media for English teaching learning
Authors: Sunjayanto Masykuri Edi , Basuki Basuki
Published: March 2024

This research was to find out the students’ perception towards digital  media for ELT in Purworejo Muhammadiyah University. This research generally answered the question: how is students’ perception towards digital  media for ELT  in Purworejo Muhammadiyah University. The researchers collected the data through a questionnaire. There were twenty-seven of fourth semester students at Purworejo Muhammadiyah University participated in this research. This research used case-study design. Descriptive analysis was used to analyze the data from questionnaire. The result of this research showed that the students had high perception on digital media  as an English reading material. The mean score of the questionnaire was 3.55 which can be interpret in the “High” category. Besides there were some difficulties faced by students and teacher in using digital media, such as limited mobile phone facilities, limited internet packages, and poor signal problems.
Fostering student's critical reading through technology integrated instruction
Authors: Sutrisno Djoko
Published: March 2024

Students today grow up with technology devices at home and school, which transform how they study. Future education technology will alter teaching and learning by making new gadgets available to teachers and students. Thus, the study was meant to explore the impact of multimedia technology-integrated instruction on upper primary students' critical reading learning in one of Indonesia's private schools. To further comprehend the outcomes, a mixed methods study was conducted. Purposive sampling was used to choose 30 pupils as research samples. For three months, the participants were taught at least three science sessions per week utilizing multimedia technology. Instruments such as open-ended questions and questionnaires were used to collect data. The quantitative results from the questionnaire were examined and inferred using an inferential statistical t-test and descriptive statistical mean and standard deviation with a significance level of p 0.05. The qualitative data from open-ended questions were analyzed using the grounded theory coding technique. According to the findings, students were incredibly satisfied with learning science through multimedia technology because it made the lessons easier to grasp and more likely to engage, easy, and interesting. As a result, the researchers concluded that introducing multimedia technology into education had a considerable positive influence on raising student learning satisfaction and improving critical reading skills The post-test scores in the group that utilized multimedia technology are noticeably higher when the two groups are compared.
Using word cross game to impprove students’ vocabulary learning at SMK Muhammadiyah 1 Yogyakarta
Authors: Nugraheni Hilda Andira , Rokhyati Umi
Published: March 2024

This research was conducted at SMK Muhammadiyah 1 Yogyakarta. Based on the experience during the teaching practicum, it was identified that students still got problem with their vocabulary. It caused them afraid to speak English and feeling embarrassed if the word or sentence they conveyed was wrong. They also have little effort to read or look up the dictionary to know the new words. In addition, students easily got bored when learning in a conventional way. There is a problem in learning vocabulary. Based on those problems, classroom action research was conducted with two objectives: to describe the increase of students’ interest and vocabulary mastery taught using the word cross game. The subject of the research was a class consisting of 21 students. To collect the data, observation, test, and interview were done. Mixed methods were used to analyzed the data. The research was conducted in two cycles. Each cycle followed the steps of planning, acting, observing, and reflecting. The research findings revealed that the students’ interest in learning increased. They stated that learning using cross word games is fun and exciting. The other finding revealed the increase in vocabulary mastery. It was shown by the increase in score from 54.6 in post test of cycle one to 79.14 in the post test of cycle 2.  Therefore, it can be concluded that the use of word cross game improved the students’ vocabulary learning.
Students’ perceptions of using Google Meet in English online learning at Muhammadiyah Nitikan Elementary School
Authors: Soviyah Soviyah , Puspita Linda , Altawil Abdulmohsin Nasser
Published: March 2024

Google Meet is a new medium used for students and teachers in learning during COVID-19 pandemic. At Muhammadiyah Nitikan Elementary School, English learning has been carried out online by utilizing online mediums in the learning process. By using Google Meet as an alternative learning medium, students at Muhammadiyah Nitikan Elementary School have various opinions on its use. The objective of this research was to find out students’ perceptions of using Google Meet in English online learning. The research method in this research was quantitative method. The participants of this research were sixth grade students of Muhammadiyah Nitikan Elementary School consisting of 88 students, 46 female students and 42 male students. The sampling used in this research was random sampling. Questionnaire is used to collect the data which is then analyzed using quantitative methods. The results of this study showed that out of a total of 88 participants, 1 student (1.14%) has a very positive perception, 35 students (39.77%) have a positive perception, 27 students (30.68%) have a neutral perception, 17 students (19.32%) have a negative perception, and 8 students (9.09%) have a very negative perception.
Students’ perceptions of storytelling online class at the English Education Department
Authors: Amrillah Asep , Fatimah Nur , Afriandi Muhamad Argi
Published: March 2024

Due to Covid-19, virtual learning at all education levels has been implemented. Storytelling is one of the courses conducted online. The aim of this study is to find out the students’ perceptions on the importance of storytelling, the tasks in an online class of storytelling, and the advantages of learning outcome of online storytelling.

This research is qualitative. The data were collected from a storytelling class in an English Education Department in Yogyakarta. They were obtained from an open-ended question questionnaire and interview with 22 students who have attended in storytelling online class.

The results show that the students have positive perceptions on storytelling in language teaching. Two of the tasks supporting the storytelling are students’ video recording for storytelling and creating new stories. In relation to the learning outcome, the students’ views that it is advantageous to enhance speaking skills and it results in the learning product such as a story book. This study can be taken into account to improve quality, policies, and program development in English Education Department.
Figurações do desespero na ficção de Joel Silveira
Authors: Lima Cleverton Barros de
Published: March 2024

Pretende-se apresentar as inscrições estético-políticas da novela Desespero (1936) de Joel Silveira (1918-2007). O escopo do artigo trata das figurações de Silveira, ao pensar o lugar do sertanejo, frente às ameaças das secas e infortúnios, que fomentaram uma jornada de desespero mortal. A filiação literária do autor está vinculada às temáticas do Romance Social de 1930. Daí a trajetória intelectual do autor sergipano iniciar-se na construção literária do trabalhador rural Gaudêncio, dono de uma propriedade rural de plantação de fumo no interior de Sergipe. Assim, as preocupações intelectuais do jovem escritor estavam em constituir um amplo domínio dos gêneros literários, tendo em vista as suas aspirações profissionais. Não por acaso, a novela foi republicada na revista Vamos Ler! em 1937, trazendo uma visibilidade nos meios literários e intelectuais do Rio de Janeiro. Aqui, percorremos a política da ficção de Silveira, instituída em seu primeiro texto literário, que sugere uma preocupação em interpretar a condição humana do sertanejo.
O “Teatro da Natureza” no sertão do Macacu - século XVIII
Authors: Cardoso Vinicius Maia
Published: March 2024

O Sertão do Macacu se constituiu, na segunda metade do século XVIII, como área de exploração aurífera tardia na capitania do Rio de Janeiro. A partir da documentação denominada “Correspondência e documentos relativos às Novas Minas de Macacu do Rio de Janeiro, de que era superintendente geral Manuel Pinto da Cunha e Souza. Rio de Janeiro, 1786-1790”, existente na Seção de Manuscritos da Biblioteca Nacional, e mandada compilar pelo vice-rei do Brasil Luís de Vasconcelos Sousa, além de outras fontes, o presente artigo busca apresentar alguns saberes e técnicas elaboradas no contexto da ilustração portuguesa, que serviram como instrumento para a conquista deste espaço de sertão.
Estado, mercado editorial e o Anuário Brasileiro de Literatura (RJ, 1937-1944): notas iniciais de pesquisa
Authors: De Luca Tania Regina
Published: March 2024

O objetivo do artigo é compreender as razões que motivaram o lançamento do Anuário Brasileiro de Literatura (RJ, 1937-1944), sob a responsabilidade da Editora Irmãos Pongetti. Para tanto, além de delinear as características gerais da publicação, é fundamental considerar, por um lado, a postura do regime Vargas em relação à produção cultural e, por outro, o vigor do mercado editorial, então em plena expansão e que teve que conviver com a crescente intervenção do poder público. Dados provenientes do Anuário subsidiaram importantes pesquisas no campo historiográfico, contudo, ainda não se conta com estudos que tomem a coleção como objeto, desafio que começa a ser enfrentado nessas primeiras notas de pesquisa.
A Cozinheira das Cozinheiras de Rosa Maria: alimentação e saúde
Authors: Carvalhas Ana Branco
Published: March 2024

O livro de Rosa Maria, A Cozinheira das Cozinheiras, publicado em Lisboa no início dos anos 1930 conheceu grande sucesso. A obra, surgida numa época de enorme crise económica, compõe-se de uma parte sobre higiene alimentar e de outra com 500 receitas. Na primeira, contendo informações de saúde, são apresentadas tabelas do valor nutricional dos alimentos, tempos de preparação e regimes para diversas condições físicas e, na segunda, o modo de confecção dos pratos (salgados e doces), principalmente de culinária portuguesa, destinados à alimentação familiar. Analisamos os preceitos de higiene alimentar à luz dos conhecimentos atuais. Ajudamos a clarificar a identidade da autora, que assinou outros livros, ainda não está clara, assim como a relação do livro com um livro brasileiro de autora homónima e com capa muito semelhante. Assinalamos que várias receitas são copiadas de um livro português com um título quase igual.
Cem anos de socialização no refeitório do Colégio Pedro II (1837-1937): um estudo sobre práticas sociais e alimentação
Authors: Nogueira Renata de Souza , Carvalho Maria Cláudia da Veiga Soares , Kraemer Fabiana Bom
Published: March 2024

O artigo traz reflexões sobre a alimentação, enquanto prática social, no período demarcado pelo primeiro centenário do Colégio Pedro II (1837-1937), importante instituição de ensino do Brasil. Compreender a alimentação em sua complexidade demanda um exercício exploratório de aproximações dos diferentes núcleos [de saberes] história, antropologia, sociologia, comunicação, nutrição, psicologia- que estruturam o pensamento sobre esse fenômeno. Considerando essa interdisciplinaridade é que traçamos como o objetivo desta pesquisa, compreender como a escola, enquanto espaço de socialização, medeia as práticas alimentares de jovens estudantes. Para tal, utilizamos de fontes primárias da instituição, tais como regulamentos e regimentos internos, além do documento Memória Histórica do Colégio de Pedro Segundo, de Escragnolle Doria (1997). Recorremos às noções de representações para estudar os textos entendendo-os como discursos e práticas do mundo social que os tornam inteligíveis e possíveis. Identificamos que as relações sociais estabelecidas em torno da alimentação podem ter contribuído para a manutenção da ordem, disciplina, organização, estruturação do poder e fortalecimento da hierarquia social interna no Colégio Pedro II ao longo dos anos, ao mesmo tempo que também favoreceu a diferenciação dos estudantes dessa escola em relação a outros.
Mentoring and coaching: ACPN Workshop 2023
Authors: Thorpe Gabrielle , Hides Cheryl
Published: March 2024

The ACPN looks back at their 2023 workshop, where they explored the key differences between mentoring and coaching, guiding nurses to unlock their leadership potential. This article explores strategies and techniques for effective growth-focused support
Creating a Coherent Design Language
Authors: Wilkie David
Published: March 2024

From Case IH’s Steiger 715 Quadtrac to its smallest Farmall Electric, David Wilkie explores how to maintain aesthetic consistency