bluuebunny/crossref_metadata_2025 huggingface dataset:
Productos forestales no madereros. Septiembre 2023
Authors:   Instituto Forestal (Chile), Poblete Pamela
Published: December 2023

Boletín de Productos Forestales No Madereros es una publicación semestral que contiene las cifras de las exportaciones chilenas para este segmento de productos, sus países de destino y las empresas involucradas. También incluye temas destacados de la evolución de las exportaciones de un producto no maderero seleccionado o información de las actividades de INFOR en el ámbito de los PFNM, en base a documentación especializada. Los números del Boletín PFNM se publican en marzo y septiembre. La edición de septiembre contiene cifras actualizadas de exportación del primer semestre del año en curso.
Mercado forestal Septiembre 2023
Authors:   Instituto Forestal (Chile), Kahler Carlos , Gysling Janina , Alvarez Verónica , Pardo Evaristo
Published: December 2023

Mercado forestal es una publicación trimestral que incluye en sus primeras páginas los elementos e indicadores que marcan la coyuntura económica nacional e internacional. Luego contiene un artículo sobre las exportaciones del período, documentos de análisis, noticias y un conjunto de series de precios de productos forestales tanto en el mercado externo como en el interno. Mercado forestal se publica en marzo, junio, septiembre y diciembre de cada año. La edición del mes de septiembre contiene las cifras de exportaciones hasta el mes de julio del año 2023.
PENYULUHAN TENTANG BAHAYA NARKOBA PADA PEMUDA DAN REMAJA KELURAHAN BATULUBANG KECAMATAN LEMBEH SELATAN KOTA BITUNG
Authors: Devie S. R. Siwij  , Margareta O. Sumilat
Published: December 2023

Angka prevalensi pemuda dan remaja (pelajar baik siswa SD. SMP dan SMA) yang pernah pakai Narkoba  merupakan kalangan yang cukup rentan bahkan pernah pernah memakai Narkoba dalam satu tahun terakhir sebesar 6,4% untuk kelompok responden yang pernah pakai Narkoba dan 3,5% untuk kelompok responden yang pernah memakai Narkoba dalam setahun ini. Angka prevalensi satu tahun terakhir pakai lebih kecil dibandingkan angka prevalensi pernah pakai. Ini menunjukkan bahwa banyak penduduk usia 15-64 tahun yang pernah memakai Narkoba dalam satu tahun terakhir sudah tidak memakai lagi. Apabila dibandingkan dengan angka prevalensi nasional setahun terakhir pakai tahun 2017 sebesar 1,77%, terjadi peningkatan angka prevalensi sebesar 0,03%. Ini berarti jumlah pengguna Narkoba mengalami peningkatan. Pemuda remaja yang ada di kelurahan Batulubang Kecamatan Lembeh Selatan Kota Bitung memiliki pengetahuan yang kurang soal Narkoba, Tapi sebagai wilayah yang dekat dengan pelabuhan laut menjadi sangat rentan terpapar dengan bahaya Narkoba. Untuk itu perlu diberikan pengetahuan tentang Narkoba dan bahayanya karena usia merka rentan terhadap terpapar Narkoba
PENGUATAN PEMBELAJARAN BAHASA ARAB PADA MADRASAH BINAAN FAKULTAS ILMU TARBIYAH DAN KEGURUAN UNSIQ JAWA TENGAH
Authors: Sri Haryantol  , Ngarifin Sidhiq  , Abdul Majid
Published: December 2023

Lemahnya sumber daya, serta kelangkaan rujukan-rujukan (referensi), keusangan materi pembelajaran Bahasa Arab, juga sangat mempengaruhi kualitas pembelajaran Bahasa Arab pada Sekolah/Madarsah Binaan FITK UNSIQ Jawa Tengah di Wonosobo. Tujuan dilaksnakannya pengabdian kepada masyarakat Penguatan pembelajaran Bahasa Arab pada Madrasah binaan Fakultas Ilmu Tarbiyah dan Keguruan UNSIQ Jawa Tengah, diantaranya adalah meningkatnya kemampuan Bahasa Arab lisan dan tulis dan hasil belajar siswa pada Sekolah/Madrasah Binaan FITK UNSIQ Jawa Tengah di Wonosobo. Metode yang digunakan dalam pengabdian ini adalah Analisis SWOT, FGD, Pemetaan Kelompok Sasaran (mapping), Pelaksanaan pengabdian dilakukan dalam bentuk pelatihan dan focus group discution. Hasil kegiatan pengabdian ini adalah Kehadiran Peserta tidak mencampai 100 % sesuai yang direncanakan, karena ada beberapa madrasah yang sedang akreditasi. Heteroginitas peserta mengakibatkan perbedaan kepentingan, latar belakang pengalaman lapangan dan latar belakang pendidikan. Hal tersebut mengakibatkan beberapa modifikasi baik strategi maupun metode dan juga perlakuan serta pengelolaan pelatihan secara umum.
PENDAMPINGAN PEMBUATAN KEBUN BUAH UNGGUL PROGRAM FIP-2 KTH MERTESARI DESA SENGGIGI KABUPATEN LOMBOK BARAT
Authors: Agung Widya Wardhana  , Zainal Arifin  , Siti Zainab  , Ahmad Zaini  , Nikmatul Aini
Published: December 2023

Gapoktan Mertesari merupakan salah satu Kelompok Tani Hutan di Wilayah KPH Rinjani Barat yang ditetapkan sebagai salah satu kelompok yang mendapatkan hibah Pembangunan Kebun Buah Unggul (KBU) FIP-2 Tahun 2022. Program ini bertujuan untuk mempercepat perluasan penutupan lahan kawasan hutan, sekaligus menciptakan sumber pendapatan yang potensial bagi anggota Kelompok Tani Hutan. Pembangunan Kebun Buah Unggul FIP-2 ini hanya merupakan stimulant bagi Gapoktan Mertesari dan Masyarakat sekitarnya, untuk terus mengembangkan Kebun Buah Unggul di lahan-lahan yang masih terbuka secara mandiri, baik di dalam maupun di luar kawasan hutan. Peran serta pemerintah Desa juga akan sangat membantu perkembangan kebun bibit di wilayah Desa Senggigi, melalui investasi pengembangan usaha-usaha produktif berbasis sektor kehutanan. Pendampingan dilaksanakan oleh Tim Program Studi Agroteknologi Universitas 45 Mataram bekerjasama dengan Kesatuan Pengelolaan Hutan (KPH) Rinjani Barat. Kegiatan pendampingan yang dilaksanakan selama sepuluh bulan ini dimaksudkan agar pembangunan Kebun Buah Unggul sesuai dengan ketentuan yang dipersyaratkan oleh proyek FIP-2, sekaligus sebagai pembinaan bagi kelompok dalam kegiatan pemeliharaan tanaman dan penguatan kapasitas kelompok
Digital Whiteboards as a Form of Effective Communication in Blended Learning environment
Authors:   South-West University “Neofit Rilski”, Levunlieva Milena
Published: December 2023

The present study offers a constructivism-informed answer to the question what to do in post-Covid environment when school-goers share an almost universal assumption that studying does not necessarily mean being at school. To pursue this goal, the survey method is used in exploring students’ changed perceptions of learning. These perceptions arguably stem from the past 2 years of lockdowns when blended learning became the only form of reaching both on-ground and online students attending the same classes. The focus is on a technology specifically designed to improve computer-mediated communication and enhance its role in student motivation and the evaluation of both the quality of educational results and the process of their achievement in blended learning environment. The survey, conducted with high school students, gives grounds to optimize electronic courses and encourages a re-conceptualization of the application of blended learning during on-ground classes in the light of students’ perceptions for streamlining the educational process in terms of both time and resources.
Visualization Problems in Mathematics for the Third Class through Animated Scenarios in an Electronic Learning Environment
Authors:   Plovdiv University, Radev Vilislav , Hristov Hristo
Published: December 2023

The paper aims to present the development of educational content such as animated scenarios for teaching the topic “Division of two-digit and threedigit numbers by one-digitˮ. Visually animated examples through which to present the division of two and three-digit numbers by one-digit ones in an electronic environment, simulating situations close to real life are discussed. The purpose of the publication is to present the development of animated scenarios for teaching the discussed topic in one with its teaching method. The environment chosen for the development of the animated examples is Scratch, due to its rich technical tools and its familiarity with the students.
Transformative Learning and Non-Formal Education
Authors:   Sofia University, Nikolaeva Silvia
Published: December 2023

The article presents the results of a study aimed at identifying and analyzing the conceptual frameworks and dynamics of the steadily growing research interest in the transformative potential of non-formal education. The main research question addresses the leading features of the identified conceptual and thematic interlink, correlation between non-formal education and transformative learning, as it has developed over the past 2 decades. The methodology of the study combines bibliometric analysis and literature review of a broad range of selected samples of articles, scientific reports and books (based on data available in Scopus) after 2000. The analysis of the data has clearly demonstrated that, during the period under review, the interrelationships between transformative learning and nonformal education has been in the focus of research increasing quantitative dimensions and an expanding holistic conceptual scope. The latter relates primarily to the field of lifelong learning by adults and young adults with a focus on education for sustainable development. These conclusions give ground to expectations that non-formal education will continue to set innovative directions for transformative learning and development.
Nutritional Awareness of Undergraduate Healthcare Students
Authors: Friebohle Lisa , Ward Maggie , Habtemariam Maryon
Published: December 2023

Overweight and obesity rates are an epidemic in the United States (U.S.) with these rates increasing dramatically in recent decades (Sogari et al., 2018). According to McEligot et al. (2020) college students classified as overweight and/or obese in the U.S. increased from 29% to 32.5% from 2000 to 2009. College is a critical time for young adults in terms of dietary choices and the relationship between students and weight gain. The purpose of this DNP project was to assess if undergraduate healthcare students in the Midwest showed poor nutritional dietary habits and showed a willingness to change their poor habits for a healthier lifestyle. The data would be used to assist the college healthcare clinic in providing proper nutritional awareness and guidance for the students. Undergraduate nursing students at a Midwest university completed an assessment tool, in the form of a 16-question Rapid Eating and Activity Assessment for Patients, Abbreviated Version (REAPS) survey that assessed their knowledge regarding nutrition and their food choices. Each question had a numeric scale (1-3) scoring system with defined results. The descriptive statistics tool in SPSS was used for analysis of the survey results. This study showed that 62.43% of the responses from undergraduate nursing students that were surveyed had poor dietary habits. 96.29% of the students that were surveyed did have a willingness to change in order to have a healthier lifestyle. Undergraduate healthcare students would benefit from increased nutritional awareness while on and off campus. The college health clinic can help promote a healthy lifestyle and decrease obesity related illnesses for students. There are numerous opportunities for colleges to promote nutritional awareness among their student body.
Differences in Quality of Female Nursing Work Life Based on Gender and Nursing Perspectives
Authors: Wijaya Dodi , Rosyidi Muhammad Nur Kholid , Asmaningrum Nurfika , Rizky Amalia Dinda
Published: December 2023

The quality of a nurse’s work life is the degree of satisfaction regarding personal and organizational needs based on experience in a work organization. A nurse with a dual role is the nurse who acts as a mother and a professional nursing staff at the same time. The purpose was to determine differences in the quality of female nurses’ work life in gender and nursing perspective at Balung General Hospital and Kalisat General Hospital in Jember Regency. The research method uses a comparative study with a quantitative research type. The sampling technique in this research is random sampling with a total of 115 samples. Data collection was conducted by using questionnaires about the quality of nurses’ work life from the nursing perspective and questionnaires conflict with women’s dual role from the gender perspective. Data processing using the Mann-Whitney analysis test with a 95% significance level (α=0.05). The results using Mann-Whitney analysis showed that there is a difference between the gender perspective and the nursing perspective (p=0.000). The mean results showed that the nursing perspective ()  is higher than the gender perspective (). The conclusion shows that the quality of female nursing work life from the gender perspective needs to be improved. The hospital needed to review further regarding work schedules and shift time; the family needed to provide full support and good cooperation; and female nurses themselves must also have good coping control, time, and energy management. Apart from that, it is necessary to have a policy from the room head and team leader regarding the distribution of schedules for female nursing staff without reducing the feeling of unfairness for male health workers.
Analysis of Psychosocial Factors Affecting Physical Activity Behaviour of People with Type 2 Diabetes Mellitus in Indonesia
Authors: Rondhianto  , Kushariyadi  , Issabella Nanda Basuki Pinky
Published: December 2023

Physical activity exercise is an essential component in comprehensive diabetes management. Non-adherence to physical activity exercises can lead to poor metabolic control, causing increased complications, morbidity, and premature death due to diabetes. One of the factors that can determine the behavior of physical activity is the psychosocial factor of people with T2DM. The study aims to assess the effect of psychosocial factors on physical activity behavior. This study was an analytical observational with a cross-sectional approach. The sample size was 138 respondents with multistage random sampling. The dependent variable was physical activity behavior, and the independent variables were psychosocial factors (knowledge, coping, distress, perceptions of family support, and perceptions of nurse support). Data analysis used multiple linear regression (α=0.05). Psychosocial factors that influenced the physical activity behavior were distress (p=0.001 < α=0.05). Meanwhile, knowledge, coping, perceived family support, and perceived nurse support did not affect physical activity behavior (p=0.684; p=0.919; p=0.235; p=0.108 > α=0.05) with Adjusted R2=0.113 (F=4.502; p=0.001 < α=0.05). Psychosocial factors that influence physical activity behavior in T2DM patients are diabetic distress. Therefore, health workers, in providing health services as much as possible, must be able to prevent and reduce diabetes distress to increase the physical activity behavior of people with T2DM.
How to build an IoT device with low-power sleep
Authors: Haßler Björn ,   Open Development & Education
Published: December 2023

An output of the Open Development & Education, https://.opendeved.net/
Biomarcadores de riesgo cardio-metabólico-renal: una revisión
Authors: Nieto-Cárdenas Olga Alicia
Published: December 2023

Contexto: el riesgo cardiovascular confluye con el metabólico y el renal.
Objetivo: revisar los biomarcadores moleculares del riesgo cardio-metabólico-renal en Armenia, Quindío.
Metodología: una revisión narrativa de los estudios sobre biomarcadores moleculares de riesgo cardio-metabólico-renal relacionados con dislipidemia, hipertensión, eventos coronarios, enfermedad renal, accidente cerebrovascular, retinopatía, obesidad e inflamación.
Resultados: se presentan 24 estudios relacionados con los biomarcadores de riesgo y la situación encontrada. Los biomarcadores del riesgo cardio-metabólico-renal más usados en la práctica clínica están relacionados con perfil lipídico, colesterol, triglicéridos, LDL y HDL, los cuales hacen parte de la ecuación de Framingham y de los criterios del síndrome metabólico. También se usan frecuentemente la troponina, la creatinina, la glicemia, la hemoglobina glicosilada y la vitamina D. Estudios sobre otros biomarcadores tales como las subfracciones de HDL2 y HDL3, la Apo-A1, la LCAT, la CETP y la PON1, la homocisteína, la ECA, la insulina y la leptina, las MMP o algunas citocinas son limitados y describen el resultado del estudio en toda la población y no específicamente en la población en riesgo.
Conclusiones: la presente revisión aporta que los biomarcadores del riesgo cardiometabólico más usados en la práctica clínica cotidiana en una ciudad colombiana están relacionados con el perfil lipídico y su tendencia muestra altos niveles de colesterol y bajos de HDL. También son de uso frecuente la troponina, la creatinina, la glicemia, la hemoglobina glicosilada, la TSH y la vitamina D. Además, la evidencia en los estudios sobre el uso de otros biomarcadores moleculares es limitada.
Síndrome de quilomicronemia familiar, deficiencia del factor de maduración de lipasa
Authors: Calvopiña-Rea Joffre Andrés , Reyes-Silva Carlos Alberto , Acosta-Naranjo William Daniel , Baquero-Contreras Stefany Alexandra
Published: December 2023

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Introducción: el síndrome de quilomicronemia familiar se considera un trastorno autosómico recesivo, poco frecuente, que puede presentarse clínicamente desde la infancia, pero se manifiesta después de su debut a cualquier edad. Clínicamente se presenta con dolor abdominal, pancreatitis aguda recurrente, xantomas cutáneos y hepatoesplomegalia. Por NGS su confirmación precisa que la variante encontrada siempre es bialélica; los progenitores por definición son heterocigotos para la misma variante y no presentan la enfermedad, solo portan la mutación sin presentar síntomas.
Objetivo: investigar la presencia de la quilomicronemia y determinar su patrón de herencia, ya sea como una forma familiar con un patrón monogénico bialélico o como una condición de naturaleza multifactorial.
Presentación del caso: se presenta el caso de un paciente con múltiples comorbilidades que acude por dolor abdominal e hipertrigliceridemia de etiología no filiada, al cual se le envían estudios genéticos para filiar la etiología y establecer un tratamiento adecuado.
Discusión y conclusión: se realiza un estudio genético de análisis molecular por secuenciación de nueva generación, identificado en homocigosis en el gen LMF1. Esta variante se caracteriza por ser patogénica. Para diagnosticar el síndrome de quilomicronemia se deben identificar variantes bialélicas no patogénicas en el complejo LPL y proteínas relacionadas. El tratamiento consiste en la restricción de grasa en la dieta para reducir la morbilidad y mortalidad, así como el seguimiento por parte de genética para el estudio de familiares con riesgo.
Comparing Technology Entrepreneurship and Social Innovation: An Analysis of France's Position Relative to China and US
Authors:   ESCT Business School, Manouba University, Tunisia, Ghodbane Walid
Published: December 2023

This research paper compares the positions of France, China, and the United States in the fields of technology entrepreneurship and social innovation. The paper explores the various factors that have contributed to France's lagging position in these areas relative to China and the US. Through an in depth analysis of policy frameworks, cultural attitudes towards entrepreneurship, and investment patterns, this paper offers insight into how France can improve its innovation ecosystem. The paper concludes by highlighting the importance of policy and cultural changes in fostering innovation, and the need for France to adopt a more proactive approach to innovation in order to remain competitive in the global economy.
A Study on Afghanistan Pakistan Transit Trade Agreement
Authors:   Department of Business Administration, Faculty of Economics, Bost University, Helmand Afghanistan, Watandar Arsalan
Published: December 2023

The relationship between Afghanistan and its neighbor country Pakistan unceasingly continued anxious thru inferences meant for the political economy. since 1950s, the entrée to ocean remained serious for financial development of Afghanistan due to fronting thoughtful transportation difficulties by Pakistan. It is expected that consequences found as of the research will deliver a better thoughtful of the significant reason of Afghanistan Pakistan Transit Trade Agreement efficiency for bilateral trade and disclose the main challenges between Afghanistan and Pakistan. The current research purposes to find out the Trade Relation between Afghanistan and Pakistan. This research designates the procedures and methods that the scholar used while conducting research. The chapter is made up of design, population, sampling techniques, sampling size, data collection procedures, data analysis procedure, questionnaire was designed in 5 Likert-scale and was distributed to 100 participants. Research shows most of candidates agreed that Ambiguities in the rules and procedures pertaining to bonded carriers should be removed as well as the participants agreed that Afghanistan Pakistan Transit Trade Agreement is the best framework for expanding business relations between Afghanistan and Pakistan if implemented perfectly, therefore it was recommended that both countries must remove uncertainties and barriers in the rules and procedures pertaining to bonded carriers. The limitation of study was lake of interest of participants to participate in this study.
Viajar de manera inestable entre signos
Authors: Eltit Diamela , Bizzarri Gabriele
Published: December 2023

Diamela Eltit, con una presentación de Gabriele Bizzarri – Viajar de manera inestable entre signos
José Santos Herceg, Lugares espectrales. Topología testimonial de la prisión política en Chile
Authors: Musso Giulio
Published: December 2023

José Santos Herceg, Lugares espectrales. Topología testimonial de la prisión política en Chile

(Santiago de Chile, Editorial USACH, 2019, 293 pp. ISBN 978-956-303-414-1)

por Giulio Musso
Segnalazioni/Informes/Rapports/Reports
Authors: Monegato Emanuele
Published: December 2023

Andrew Sneddon, Representing Magic in Modern Ireland: Belief, History, and Culture, Cambridge, Cambridge University Press, 2022, 75 pp. ISBN 978-11-08949-27-9

Tim Ingold, Antropologia come educazione, Bologna, La Linea, 2019, 140 pp. ISBN ‎978-88-97462-65-1
Habiter la ville et ses territoires aux XIe-XIIIe siècle. Recompositions territoriales et cospatialité en Italie centro septentrionale
Authors: Fulconis Maxime
Published: December 2023

Cet article étudie les territoires auxquels les habitants des villes d’Italie centro-septentrionnales ont le sentiment d’appartenir entre le xie et le xiiie siècle. Au début de la période, ils sont particulièrement attachés à leur appartenance au comté ou à une subdivision du diocèse, le piviere urbain, tout en se sentant relever de territoires de nature plus socio‑culturels. Cependant, au xiie et au début du xiiie siècles, les communes réorganisent l’organisation territoriale de la ville et, ce faisant, le sentiment d’appartenance des habitants. Les institutions communales établissent un système à deux niveaux : de grandes portions urbaines comprenant une partie des murailles et des sous‑circonscriptions, correspondant plus ou moins aux paroisses.
Si cette transformation des territoires administratifs urbains affecte grandement l’identité des habitants de la ville et leur sentiment d’appartenance à la commune et à ses institutions, elle ne conduit pas à la diminution du nombre de territoires socio‑culturels. Le chevauchement de ces nombreux territoires conduit ainsi les habitants de la ville à se considérer comme appartenant à plusieurs territoires et, donc, à cumuler les identités territoriales qu’ils ne manquaient pas de convoquer ou mettre en avant au gré de leurs intérêts. Ce riche jeu de cospatialités devient à partir du xiie siècle l’un des éléments‑clef de l’identité des habitants de la ville, ainsi que le prisme structurant une grande partie de leur manière de penser, de s’exprimer et d’agir.
«Pregando che ay se debiaset scriver»: società, alfabetismo e mediazione grafica nella Bergamo tardomedievale
Authors: Buffo Paolo
Published: December 2023

Il saggio studia gli esiti del rapido incremento del «bisogno di scrivere» che interessò la popolazione bergamasca nella seconda metà del Quattrocento. Sono analizzate le grafie tanto delle scritture private contenenti obbligazioni commerciali quanto delle polizze d’estimo. Gli effetti delle trasformazioni delle prassi documentarie sono valutati su tre fronti: la composizione del gruppo degli alfabetizzati; la distribuzione delle abilità grafiche entro i vari contesti sociali e professionali; le scelte di coloro che, per analfabetismo o inesperienza grafica, accedevano alla produzione di documenti attraverso l’opera di mediatori professionisti e non. Sono ricostruite anche le differenze tra lo spazio urbano e i territori rurali, nei quali la minore alfabetizzazione favorì l’emergere di figure di mediatori seriali, talvolta prive di competenze scrittorie di livello professionale.
Flexural Behaviour of FRC Beams Wrapped With FRP
Authors:   Department of Civil Engineering, Technocrats Institute of Technology Bhopal (M.P), India., Khan Dr. Md Imran , Khan Prof Aajid ,   Department of Civil Engineering, Technocrats Institute of Technology Bhopal (M.P), India.
Published: December 2023

Structural elements such as beams, slabs and columns may require strengthening during their service life period. A concrete structure may need strengthening for many reasons such as to increase live load capacity, to add reinforcement to a member that has been unsigned or wrongly constructed. The FRPs have various advantages like, high strength to weight ratio, corrosion resistance and ease of installation and flexibility in its use. FRP material which are available in the form of sheet are being used to strengthen a variety of RC elements to enhance the flexural, shear and axial load carrying capacity of these elements. The objective of this experiment is to strengthen the RC beams using fibres and FRP sheets in flexure. In this experimental program CFRP and GFRP sheets were applied to the bottom surface and sides of the concrete beam with different configuration and their performance in flexure were studied. In this experimental program eight RC beams of size 1500 x 150 x 200mm were casted with two 10mm dia. bars as tension zone, two 8mm dia. bars as compression zone and 8mm dia. bars @ 200mm c/c spacing as shear reinforcement. The experimental result shows that the flexural strength of FRP wrapped beams were increased in the range of 23.49% to 67.9% in comparison with the flexural strength of the control beam (unwrapped). The flexural strength of the beam wrapped with the single layer CFRP at the soffit and around the sides (for full depth of the beam) and beam wrapped with the single layer GFRP at the soffit and around the sides (for full depth of the beam) exhibits better performance compared with other FRP beams and increase in flexure was 67.9% in comparison with the capacity of the control beam.
DIAGNOSTIC ACCURACY OF RIPASA SCORE FOR DIAGNOSING ACUTE APPENDICITIS KEEPING HISTOPATHOLOGY AS GOLD STANDARD
Authors: KHAN A , MUMTAZ N , MALIK AH , KHAN SU , GUL A , ASMAT S , AMIN F
Published: December 2023

The objective of the study was to determine the diagnostic accuracy of the RIPASA score in diagnosing acute appendicitis using histopathology as the gold standard. The cross-sectional study was conducted at the General Surgery Department of Lady Reading Hospital, Peshawar, between 17-03-2020 and 16-092020. A total of 171 patients were enrolled in the study. Each patient underwent the RIPASA score, followed by an appendectomy. The appendix specimen obtained during the appendectomy was sent to the laboratory for histopathology. After receiving the histopathology study's objective, which was to determine the report, the results of histopathology, RIPASA score, and other information, including name, age, gender, and age group, were recorded. The age distribution in the sample varied from 15-65 years, with a mean age of 25.8±11.0 years. There were 114 males (66.7%) and 57 females (33.3%). The RIPASA score had a sensitivity of 94.9%, specificity of 64.2%, PPV of 96.7%, NPV of 52.9%, and accuracy of 92.4%. Stratification was also carried out for age and gender. Age 15-25 showed a sensitivity of 94%, specificity of 57.1%, PPV of 97.3%, NPV of 36.3%, and accuracy of 91.9%. Similarly, the age 26-65 group revealed a sensitivity of 97.5%, specificity of 71.4%, PPV of 65.1%, NPV of 83.3%, and accuracy of 93.6%. Stratification by gender showed a sensitivity of 94.2%, specificity of 66.6%, PPV of 97%, NPV of 50%, and accuracy of 92.1% for males, while for females, the sensitivity was 96.1%, specificity was 60%, PPV was 96.1%, NPV was 60%, and accuracy was 92.9%. In conclusion, the study suggests that the RIPASA scoring system is a good choice for doctors in the emergency department to aid in diagnosing acute appendicitis with good sensitivity, albeit with a slightly high profile and specificity, albeit with a bit low profile.
Limitation and development of minimally invasive robots
Authors: Niu Tong
Published: December 2023

This paper mainly uses the method of literature review to sort out and analyze the research and application fields of minimally invasive robot technology,combined with experimental research and case analysis,to explore the development trend and future development direction of minimally invasive robot technology. The research of minimally invasive robot technology has been relatively mature,but its limitations still exist,such as the accuracy of surgical instruments,the control mode of robots,and the safety in surgery.The development of minimally invasive robot technology in the future needs to consider the factors of technology, law and ethics. At the same time, it is also necessary to continuously promote the development of minimally invasive robot technology in the laboratory and practice, so as to achieve better surgical results and serve more patients. In the future development, minimally invasive robot technology will become more and more mature and new application fields will emerge, but it is still necessary to actively explore unknown areas and continuously promote the development, optimization and application of minimally invasive robot technology. This study discusses and analyzes the development trend and future development direction of minimally invasive robot technology, and puts forward suggestions and prospects for the optimization and development of minimally invasive robot technology.
An evaluation of chemotherapy, surgery and immunotherapys effectiveness in tackling pancreatic cancer
Authors: Wen Yingshi
Published: December 2023

Statistics show that among malignant tumors, pancreatic cancer has the poorest prognosis. Cancer has a low likelihood of survival, and early cancer diagnosis is challenging. The major therapies currently used include surgery, chemotherapy, and radiation, although the outcomes are not optimal. Treatments for pancreatic cancer using immunotherapy now appear more promising because to developments in molecular biology. The primary pancreatic cancer treatments will be analyzed and evaluated in this study, and it will be concluded that immunotherapy is the most promising course of action. The usage of patient range, toxicity, and other side effects are some of the difficulties, although it is still in the research and development stage.
The occurrence and development of autism from the perspective of perceptual ecology
Authors: Duan Shuhan
Published: December 2023

This paper discusses three theoretical models to explain the occurrence and development of autism disorders. The psychological model regards developmental disorders or psychopathological disorders of autistic patients as the manifestation of impaired mental activities, the neurobiological model mainly considers specific brain structure damage and its effect on behavioral dysfunction in autism. The ecological model doesnt directly study the mind or brain, instead it tries to explain the behavior of autistic people by studying their interactions with the environment. This paper will mainly focus on the ecological model of autism, autism is a process in humans life development, people who is suffer from autism, the influences of this disease will along with the entire lifetime, autism is not caused by a moment, but is a life through process. Compared with psychological model and neurobiological model, the ecological model view of autism based on perceptual ecology theory highlights the interaction between individuals and the environment, which indicates that autism can also effect by environment, outside components can consider as triggers of autism as well.
The role of sleep quality in the pathogenesis and management of Type 2 diabetes
Authors: Zhang Ashley
Published: December 2023

With a growing prevalence of both Type 2 diabetes and sleep disturbances in the population, emerging evidence suggests a potential link between sleep quality and diabetes. This review explores the role of sleep quality in Type 2 diabetes, including its association with glycemic control and the potential of sleep interventions in management. The review clarifies underlying mechanisms connecting sleep disturbances to diabetes, encompassing cortisol, melatonin, ghrelin, and leptin dysregulation. Sleep quality affects emotional well-being, contributing to stress-related insulin resistance. Exploring the intricate connection between sleep quality and glycemic control uncovers intricate patterns involving HbA1c levels and intriguing gender disparities. However, the obstacle of patient adherence underscores the necessity for nuanced strategies, including personalized approaches. The implications for diabetes management and public health resonate through adaptable care during challenging circumstances, evidence-based population health strategies, and proactive prevention efforts. Adaptable care methods, rooted in telehealth and individualized support, ensure uninterrupted diabetes management. Early intervention and prevention programs can forestall prediabetes progression, necessitating proactive public health initiatives. This review showcases the links between sleep quality and Type 2 diabetes, revealing a landscape where sleep interventions hold potential, but also emphasizing the need for holistic, patient-centered approaches in diabetes management.
Application of neural organoids in studying neurodegenerative diseases
Authors: Luo Kevin
Published: December 2023

Neurodegenerative diseases are among the top causes of mortality and the aversion of DALYs (Disability-Adjusted Life Years) worldwide. Many attempts have been made to develop therapeutics to alleviate disease symptoms without much success. The preclinical models utilized in therapeutic testing are often inaccurate and cannot precisely translate into clinical studies. The introduction of neural organoids, a three-dimensional model grown from human-originated stem cells, was able to revolutionize the field of neurological drug development. Using induced pluripotent stem cell (iPSC), scientists are able to restore adult cells pluripotency and cultivate them into region specific brain organoids using a combination of growth factors, agonists, and inhibitors. These models have proven valuable in drug screen for myriad neurodegenerative disorders. To model such diseases, iPSCs are generated from patients with the respective diseases, and then cultivated in an environment that mimics the disease environment. For example, for Parkinsons disease, Wnt pathway inhibitors and the Sonic hedgehog agonist are used to induce midbrain neural progenitor cells from patients with risk factors. Despite neural organoids wide usage in screening for neurodegenerative disorders and drug testing, neural organoids present several limitations in their function, including a lack of complexity equivalent to that of the brain. This paper will discuss neural organoid technology and provide basic insight to its usage in drug screening and the field of neuroscience.
New directions in deep brain electrical stimulation for dementia and Alzheimers disease - Advances in brain-computer interface technology
Authors: Wang Xinxin
Published: December 2023

In 2022 Alzheimers Disease Report, World Health Organization (WHO) states that Alzheimers disease and dementia have become the seventh most common causes of death in the U.S. However, there is currently no cure for Alzheimers disease and dementia, therefore research into effective treatments for Alzheimers disease is imminent. This paper introduces the incidence, pathogenesis, pathological mechanisms, and treatment of dementia and Alzheimers disease, and describes the latest research direction for Alzheimers disease - deep brain electrical signal stimulation. Although deep brain electrical signal stimulation is not commonly used to improve and treat cognitive function in Alzheimers disease at this stage of the disease, it is a very promising research direction for repairing or re-stimulating brain function. This paper suggests that it may be possible to use the emerging technology of brain-computer interfaces (BCI), equipped with deep brain electrical stimulation systems, to synchronize the input and output of electrical signals to achieve the purpose of precisely determining the electrical stimulation points. Brain-computer interface technology can also be linked to artificial intelligence technology to build personalized brain models, completing the generalization of therapeutic technology.
Relation between fat and protein from various types of food and the confirmed and death rates of COVID-19
Authors: Wang Xueting
Published: December 2023

In the past three years, all countries and populations have been challenged by COVID-19 in the economy, education, lifestyle, etc., and it has raised concerns about food security. Some researchers demonstrated the effective role of diet in COVID-19, but the analysis of various types of fat and protein from diet was still required. This study focused on the impacts of fat and protein from various kinds of food on the confirmed rate and death rate of COVID-19. The study used Pearson Correlation and Linear Regression to deplore the impacts of diet on the confirmed and death rates of COVID-19 based on data on the food supply of all countries from the United Nations and data on confirmed cases and deaths of COVID-19 from John Hopkins University. The results showed that the confirmed rate and death rate of COVID-19 had a positive relation with the intake of fat from animal products, eggs, meat, and tree nuts and were reduced with higher consumption of fat and protein from cereals, fish and seafood, oil crops, pulses, and vegetal products.
Dengue virus and vaccines: A review
Authors: Wang Meicheng
Published: December 2023

Dengue disease is a significant global health issue with nearly 400 million infections per year. Therefore, it is vital to developed a universal dengue vaccine. However, developing such a vaccine faces major challenges including risk of ADE, lack of predictive animal models, and insufficient immunological correlates of protection. First licensed dengue vaccine Dengvaxia showed increased risk of severe dengue likely due to ADE from imbalanced immunity against the four dengue serotypes. This review summarizes current dengue vaccine candidates like Dengvaxia, TAK-003, and TV003/TV005. It highlights the mechanisms and implications of ADE in vaccine-induced immune responses. Potential innovative solutions are discussed including focusing on highly neutralizing epitopes like envelope domain III and leveraging new vaccine platforms such as virus-like particles and mRNA vaccines. These approaches may improve the quality of neutralizing antibodies over cross-reactive enhancement-prone responses. However, definitive immunological correlates for protection remain unknown. Continued research is urgently needed to enable universal dengue vaccine that provides long-lasting immunity against all serotypes without risk of ADE.
Breast cancer survival data prediction using machine learning model
Authors: Zhao Yucheng
Published: December 2023

Breast cancer is the most common form of cancer affecting women, exerting a significant impact on individuals, families, and societies globally. With its multifaceted nature, breast cancer research and awareness efforts have gained substantial momentum, leading to transformative breakthroughs in understanding its causes, diagnosis, treatment, and prevention. Survival analysis is a pivotal statistical tool in understanding the dynamic and often complex trajectory of breast cancer. As a disease that evolves, breast cancer research benefits immensely from survival analysis, which provides insights into patient outcomes, treatment efficacy, and the influence of various factors on survival. In this paper, Habermans Survival Dataset is used to analyze the data on breast cancer. The primary objective of this study is to establish the correlation between input and output variables, along with identifying significant features. The overarching aim of this research is to assess and compare the efficacy of various machine learning models in order to ascertain the optimal one.
Exploratory analysis of the contributing factors of stroke
Authors: Luo Xi
Published: December 2023

Stroke is a medical condition that occurs when the blood supply to the brain is interrupted, which causes cell death. Previous studies have shown that the leading risk factors of stroke include elevated systolic blood pressure, poor diet, high body mass index, high fasting plasma glucose, ambient particulate matter pollution, smoking, high low-density lipoprotein, kidney dysfunction, alcohol use, and low physical activity. However, how these factors differentially contribute to the occurrence of stroke remains elusive. In this study, 5110 cases and 11 risk factors were investigated and machine learning models were built to predict the occurrence of stroke and the importance of each of the factors. It was found that the random forest model showed the best performance in predicting stroke and age, glucose level, and body mass index were the top three most important risk factors underlying stroke. These findings shed light on future research in the prevention and diagnosis of stroke.
Advances in understanding RSV glycoproteins: Insights into viral entry and implications for vaccines and therapeutic development
Authors: Haoyu Wang
Published: December 2023

Respiratory syncytial virus (RSV) causes a significant number of deaths in newborns annually due to respiratory infections. Since its first isolation in 1955, great progress has been made in the development of related vaccines and monoclonal antibodies. Currently, two RSV vaccines and two monoclonal antibodies have been approved for marketing. Understanding the structure, function, and mechanism of RSV glycoproteins interaction with their receptors involved in its entry is of great significance for the development of vaccines and therapeutic drugs. In this review, we will introduce the substantial progress made in the understanding of the structure of RSV glycoproteins, the receptors they bind with, and the process of RSV entry. Progress made in developing vaccines and neutralizing antibodies which benefit from these studies will also be briefly discussed. Finally, we will outline the unresolved issues and controversies in RSV glycoprotein and entry mechanism research, propose some possible approaches to address these issues, and provide insights into future drug and vaccine development.
CRISPR/Cas9 in the treatment of -thalassemia
Authors: Li Yingrui
Published: December 2023

-thalassemia is a congenital hemolytic anemia, a class of hemoglobinopathies caused by a common single-gene recessive condition in which the synthesis of the chain is either totally or partially blocked. About 50% of patients have symptoms within the first three months of life. At birth, the disease is often asymptomatic, and it mostly gets worse during infancy. If left untreated, the disease usually claims its victims by the time they are five years old since its severity rises with age. Currently, there is no cure for this disease, and the main treatment is blood transfusion. With the continuous progress of medical level, gene editing technology is developing rapidly, among which CRISPR/Cas system as a gene editing technology has been applied in the research of single gene genetic disease treatment, and CRISPR/Cas9 has been widely used in the research of treating geopathic anemia because of its high efficiency, low cost, and high specificity, for example, repairing pluripotent stem cells HBB genes, inducing fetal hemoglobin expression and inhibition of HBA gene expression. This review methodically explains the development of CRISPR/Cas9 through its creation and mode of operation, various research hypotheses tested in animal studies and clinical trials, as well as analyses of safety concerns.
Construction of tumour disease models based on CRISPR/Cas and iPSC technology
Authors: Meng Fei
Published: December 2023

Cancer, which is defined as malignant tumours and neoplasms, is one of the most concerned diseases in the world. According to the WHO website, almost 10 million of people lost their lives due to cancer in 2020. The complexity of tumorigenesis and cancer development, which have not been explored enough, lead to its high morbidity and mortality. Therefore, it is in an urgent need to establish stable and reliable tumour disease models to study the complicated pathogenesis, hence developing novel therapies and drugs. As the third generation of gene-editing technology, CRISPR/Cas system has the advantages of high suitability to all types of model forms owing to the simplicity and convenience of operation. It can efficiently construct tumour disease models for verifying and screening related targets. iPSC, as a stem cell technology, can provide a new cell source for CRISPR/Cas system-based tumour disease modelling. It can be the basic of establishing disease models in specific areas like brain tumours. This review introduced the advantages of CRISPR/Cas gene editing and iPSC technology in establishing disease models and the combined application strategies of the two technologies through the cases of tumour disease modelling in the past five years. It also explored the modelling strategies and model categories adopted in the popular cancer field.
The effectiveness of estrogen therapy and aerobic exercise combined with resistance training therapy in postmenopausal womens osteoporosis
Authors: Hu Tianrui , Xiang Zijie , Zhang Xiaochi
Published: December 2023

Postmenopausal osteoporosis (PMOP) usually happens five to ten years following a womans menopause, and some women over 50 in China suffer from PMOP. Hormone replacement therapy (HRT) and aerobics combined with resistance training are the two promising osteoporosis interventions, but few studies have compared their efficacy. The mechanisms by which exercise treatment and hormone replacement therapy affect bone mineral density (BMD) are examined in this review and other health parameters in postmenopausal osteoporosis patients. As studied in this paper, estrogen improves osteoporosis. However, risks such as venous thromboembolism limit the long-term use of HRT. In terms of exercise therapy, a direct comparison of aerobic exercise combined with resistance exercise and HRT showed that supervised exercise improved BMD more than HRT and that exercise also boosted metabolism and avoided the risks of HRT. In conclusion, aerobic and resistance training provides a safer alternative to HRT for managing postmenopausal osteoporosis, and further studies should optimize exercise regimens.