bluuebunny/crossref_metadata_2025 huggingface dataset:
Поема «Младенчество» В. Іванова в контексті символістської життєтворчості
Authors: Свенцицька Еліна
Published: September 2021

Мета. Стаття присвячена аналізу поеми В. Іванова «Младенчество» в світлі символістського трактування поняття життєтворчості. Метою роботи є виявлення в авторській стратегії даного твору теургічних і життєтворчих інтенцій. Дослідницька методика. Аналізуючи твір, ми користувалися методом цілісного аналізу, розробленим донецькою філологічною школою, а також методом герменевтичного аналізу, базуючись на положеннях Г.- Ґ. Ґадамера, висловлених в статті «Істина і метод», – тобто, відтворення смислової перспективи, властивої даному авторові. Результати. В статті послідовно розглянуто специфіку авторської свідомості, основні образи й мотиви твору. Детально простежено процес внутрішнього перетворення особистості для досягнення взаємозверненості людини й митця в процесі як художньої творчості, так і творчості буття. Робиться висновок про те, що автор знаходиться між двома реальностями: реальністю сакральною в самому загальному смислі і реальністю життєвою, яка в системі світобачення модернізму осмислюється як хаос. Поема В. Іванова «Младенчество» – це спроба зрозуміти життєвий хаос за допомогою релігійного космосу, звернути їх один до одного у взаємопроникливому освітленні, наблизивши релігію до конкретної особистості з її духовними проблемами. Наукова новизна. Завдяки розгляду поеми В. Іванова в контексті символістської життєтворчості вперше встановлені систематичні й взаємозбагачуючі зв’язки між поетикою слова й філософією слова всередині творчого досвіду В. Іванова. Практичне значення. Результати даного дослідження можуть бути використані в лекційних курсах і практичних заняттях з історії російською літератури кінця ХІХ – початку ХХ сторіччя, при розробці нових навчальних посібників з літератури даного періоду.
Radial permeability of the hybrid pine (Pinus elliottii × Pinus caribaea) in Australia
Authors: Leggate William , Redman Adam , Wood Jeff , Bailleres Henri , Lee David J.
Published: September 2021

The radial permeability (gas and liquid) of the hybrid pine (Pinus elliottii var. elliottii [PEE] × Pinus caribaea var. hondurensis [PCH]) was investigated for wood samples collected from 30 trees that were 19 years of age and represented various genotypes and stocking rates. The PEE × PCH hybrid is now a very important resource for the Australian forestry industry, producing logs used to manufacture a diverse array of wood products. The permeability of wood influences many important wood properties and industrial processes. For all data combined from all radial sampling positions, there was no significant effect of genotype and stocking rate on radial permeability. Both gas and liquid permeability increased from pith to bark positions within the tree. Conversely, resin content decreased from pith to bark positions. Gas and liquid permeability were significantly positively correlated, and a highly significant negative relationship was also found between permeability (gas and liquid) and resin content.
ISCHEMIA Trial: Key Questions and Answers
Authors: Lopez-Sendon Jose , Moreno Raúl , Tamargo Juan
Published: September 2021

A healthy lifestyle, myocardial revascularisation and medical therapy constitute the three pillars for the treatment of ischaemic heart disease. Lifestyle and optimal medical therapy should be used in all cases. However, the selection of cases for revascularisation among stable patients remains controversial. The ISCHEMIA trial compared an early invasive strategy with revascularisation plus optimal medical therapy against initial optimal medical therapy alone with revascularisation reserved for cases in which symptom control was insufficient. The study included over 5,000 patients with stable coronary artery disease and moderate to severe myocardial ischaemia. No differences were found in relevant clinical outcomes, including all-cause mortality, cardiovascular death, MI, heart failure and stroke, over a follow-up of 3.2 years. Conversely, angina control was better in patients with severe symptomatic angina. Following the tradition of all trials comparing medical therapy alone with revascularisation, the ISCHEMIA trial results are controversial, but an analysis of the design and results of the trial offers important information to better understand, evaluate and treat the growing number of patients with stable chronic ischaemic heart disease and moderate to severe myocardial ischaemia.
Removal of foreign bodies from the proventriculus in a young golden eagle (Aquila chrysaetos)
Authors: Kottferová Lucia , Molnár Ladislav , Major Peter , Toporčák Juraj , Mesárčová Lýdia , Kottferová Jana , Szarková Andrea
Published: September 2021

This paper presents a clinical case report of a golden eagle (Aquila chrysaetos) with foreign bodies (stones) in its proventriculus. The case deals with the identification, management and removal of foreign objects identified in the gastrointestinal tract. A surgical removal by proventriculotomy under general anaesthesia was attempted. The surgery and the recovery were uneventful, and the follow-up after six months revealed no complications. To the best of our knowledge, there are no other reports of successful foreign body removal by proventriculotomy in the golden eagle.
Does iron-fortified chewing gum influence the biochemical profile of school-going children (6–10 yrs.)?
Authors: Azeem Muhammad , Kamran Sharif Mian , Shah Fais-Ul-Hassan , Ali Maratab , Nazir Muhammad Amer , Rizwan Muhammad , Wadood Syed Abdul , Ejaz Rebia
Published: September 2021

Iron deficiency has become a common nutritional problem of developing countries, especially in children. This study approached to tackle the issue of iron deficiency by inexpensive fortified food such as chewing gums, which is commonly consumed by children. In this study, iron-fortified chewing gums were prepared by adding ferrous sulfate (FeSO4) and sodium iron EDTA (NaFeEDTA) 30 mg/100 g. An efficacy trial was conducted to determine the impact of iron-fortified chewing gums on the blood profile and iron status of school-going children (n = 300). Results showed maximum increase in blood profile and iron status that is, serum ferritin (10.43%), hemoglobin (3.22%), hematocrit (3.42%), red blood cells (3.05%), mean cell volume (1.55%), mean cell hemoglobin (5.43%), total white blood cells count (9.09%), and platelets count (4.40%) as compared with control whereas decrease in mean cell hemoglobin concentration (1.90%) and neutrophils (3.33%) was also observed. The study concluded that FeSO4 and NaFeEDTA (1:1) fortification of chewing gums is an appropriate approach for mitigating iron deficiency among the target population.
The influence of starter cultures on the lactic acid bacteria microbiota of Petrovac sausage
Authors: Milicevic Bojana , Tomović Vladimir , Danilović Bojana , Savić Dragiša
Published: September 2021

Petrovac sausage (Petrovská klobása) is a high-quality fermented dry sausage produced traditionally in the municipality of Ba?ki Petrovac (Vojvodina, Serbia). The product is characterised by specific and recognised texture, aroma and colour, produced without additives or preservatives. Lactic acid bacteria (LAB) microbiota plays an important role in production of the sausage. The aim of the paper is to monitor the changes in LAB during the production of Petrovac sausage. Samples of sausages were prepared without and with the addition of starter culture Staphylococcus xylosus as well as combined starter culture Lactiplantibacillus plantarum and S. xylosus, and produced at two different temperature ranges. A total number of 495 strains were isolated from 33 samples of Petrovac sausage during 120 days of production process. Characterisation of the isolates was performed by phenotypic tests, while molecular identification of the representative strains was done by 16S ribosomal DNA sequencing. The total number of LAB was about 8 log (Colony Forming Unit (CFU))/g in all samples, while the number of staphylococci was about 4 log CFU/g. Molecular identification confirmed that all isolates belonged to the following species: Levilactobacillus brevis, Leuconostoc mesenteroides, Lactiplantibacillus plantarum and Pediococcus pentosaceus. Lactobacilli and Leuconostoc spp. dominate the total LAB strains, while P. pentosaceus was isolated at the lowest frequency.
Composition and nutritional evaluation of amino acids in Mimai Qu rice wine
Authors: Zhang Kaizheng , Wu Wenchi , Zou Wei , Kang Zhenhui , Yan Qin , Qin Yue
Published: September 2021

An amino acid analyzer was used to detect free amino acids (FAA) in Mimai Qu rice wines (SMW and DMW) and control wine samples (Chinese rice wine [CRW] and Japanese sake [JNS]). It was found that CRW had the highest total amino acid (TAA) content (~2814 mg/L), followed by SMW (~2509 mg/L) and DMW (~1474 mg/L), while JNS had the least (~917 mg/L). Amino acid ratio coefficient method (SRCAA), linear regression method, cluster analysis (CA) and principal component analysis (PCA) were used for evaluating the nutritional value of amino acids in wine samples, giving similar results. SMW had the highest nutritional value, followed by CRW and DMW and JNS.
Direccionamiento de la investigación universitaria: aproximación teórica para su análisis
Authors: Bravo-Valero Antonio José , Madriz-Rodríguez Delia Alejandra , Ramírez-Quintero Freddy Antonio , Ugueto-Maldonado Martha Graciela
Published: September 2021

El objetivo fue desarrollar una aproximación teórica del direccionamiento de la investigación en las universidades. Fue un estudio mixto, con diseño de campo y apoyo bibliográfico, de nivel explicativo, siendo el contexto específico la Universidad Nacional Experimental del Táchira, Venezuela. El análisis reveló un sistema académico determinado por la ausencia de direccionamiento estratégico macro institucional de la investigación, reposando en el poder experto (investigadores), los logros en productividad y competitividad. Emerge una aproximación teórica constituida por tres dimensiones: el carácter estratégico del direccionamiento, la visión de conjunto del sistema institucional, y las relaciones de poder entre los actores del sistema.
Tablero de control para el seguimiento y evaluación de las políticas públicas
Authors: Velásquez-Pérez Torcoroma , Sánchez-Perilla A. L. , Puentes-Velásquez A. M.
Published: September 2021

En Colombia se diseñan Políticas Públicas que deben estar articuladas con los Planes de Desarrollo y Planes Integrales de Seguridad y Convivencia Ciudadana (PISCC) a nivel Municipal, Departamental y Nacional. Existe una preocupación a nivel nacional porquenormalmente no se hace un monitoreo ni evaluación a dichas políticas o si se realizan lo hacen de forma muy elemental. El GobiernoCorporativo busca establecer lineamientos para lograr el direccionamiento estratégico de la organización; esto es verificar el cumplimiento desus objetivos, hacer una adecuada gestión de riesgos y una optimización de los recursos. Los entes territoriales, más que cualquier otraorganización deben propender por el cumplimiento de sus objetivos, planes, programas y proyectos, facilitando el seguimiento a la ejecuciónde los recursos públicos, a la vez que gestionan adecuadamente sus riesgos. Esta herramienta de tablero de control permite el monitoreo yevaluación de los planes y programas planteados dentro de los PISCC, bajo una mirada de Gobierno de TI como un mecanismo de control delas políticas públicas.
Propuesta de valor para la creación de una empresa constructora de vivienda de interés social
Authors: González-Salgado Jorge Luis , Quintero-Quintero Wilder , Arévalo-Ascanio José Gregorio
Published: September 2021

Este artículo tiene como objetivo mostrar una propuesta de valor para la creación de una empresa constructora de vivienda de interés social (VIS), la cual genere diversos proyectos en esta modalidad, apoyado en un modelo de negocio que brinda soluciones de vivienda, en coherencia con los lineamientos y programas del Gobierno Nacional y el impulso que éste le ha dado al sector de la construcción para promover los programas VIS. Para este propósito se realizó un análisis del sector de la construcción desde el plano nacional, departamental y local para establecer la situación actual de esta industria. Se utilizó el tipo de investigación proyectiva por tratarse de proyectos factibles, que se pretenden realizar en una población 30743 familias de estratos 1, 2 y 3 de la ciudad de Ocaña, con enfoque cualitativo y cuantitativo en razón a que se utilizó la entrevista semiestructura y la encuesta mediante cuestionario. Finalmente, en los resultados y conclusiones, se obtuvo la propuesta de valor del modelo de negocio a partir de los datos obtenidos, y se diseñó el sistema operativo de la nueva empresa constructora, teniendo en cuenta el nivel de aceptación de este proyecto de VIS en la población objeto de estudio
Reliability analysis of residual service life of restored concrete bridge
Authors: Zhuang Yizhou , Easa Said , Lu Pengzhen
Published: September 2021

The Wan Jiang Bridge in China was damaged by ship impact and subsequently restored. This paper presents a detailed evaluation of the residual service life (RSL) of the bridge using the reliability analysis method of the Joint Committee on Structural Safety, based on the structural load-bearing capacity (LBC) of the bridge and the design load. Data were collected from bridge design codes, field loading tests and finite-element (FE) analysis. The LBC was initially calculated and subsequently revised using specific coefficients. Using FE analysis, the bending moment on the control section of the bridge was determined under the most unfavourable loading conditions and the ultimate LBC of the bridge was checked. Subsequently, static and dynamic loading tests on the restored bridge were conducted, with the load and capacity determined for the control section based on FE analysis. The loads considered were dead load, vehicle load and crowd load. A time-dependent reliability index was developed for the restored bridge using the probability distributions of capacity and design load variables, and the RSL was determined. This case study, predicting the RSL of the bridge based on a multitude of data, should be valuable for future bridge maintenance and management.
Briefing: Scour guidance supporting bridge resilience
Authors: Roca Marta , Kitchen Amanda , Kirby Andrew , Escarameia Manuela
Published: September 2021

This briefing provides a short introduction to a supplement of the Ciria Manual on Scour at Bridges and Other Hydraulic Structures published in 2021. The supplement captures additional knowledge since the scour manual was published in 2015. This note is intended for designers and asset managers of structures in the water environment that may be subject to scour.
The More, the Better? Effects of Multiple Modalities on EFL Listening and Reading Comprehension
Authors: Kim Na-Young
Published: September 2021

This study explores the effectiveness of multimedia modalities by comparing the effects of the use of different modality modes on EFL comprehension. The experiment was conducted during the 2020 academic year. The participants were 186 college EFL students who were selected from six intact classes at a university in Korea. They were divided into six groups at random and received the treatment depending on their experimental conditions: text-only (TO), audio-only (AO), text-picture (TP), audio-picture (AP), text-audio (TA), and text-audio-picture (TAP). For five weeks, all participants read, listened to, or both read and listened to the fairy tales with or without pictures in class. To test the modality effects, the TOEIC-based listening and reading pre- and post-tests were carried out. The whole data collected were analyzed with SPSS version 20 software. The study found that using different modalities in classes plays a beneficial role in increasing comprehension skills. TP, AP, and TA groups improved their listening skills while TO, TP, and TA groups increased their reading skills at a significance level of .05. Statistically significant group differences were also found based on experimental conditions in both listening and reading comprehension skills. Pedagogical implications and suggestions are discussed at the end.
Carbon Nanofibers Fabricated from Electrospun Nano-sized boron oxide/Polyacrylonitrile Nanofibers as electrode for Supercapacitors
Authors: KURTAN Ümran
Published: September 2021

Porous carbon nanofiber (CNF) composites are promising electrode materials for supercapacitor (SC) applications. In this research, for the purpose of developing efficient CNFs with high specific capacitance, PAN solutions introduced with nano-sized boron oxide (B2O3) were electrospun followed by thermal treatment at high temperature. The best electrochemical performance was found for the sample which was doped 1 wt% nano-sized boron oxide and a gradual decrease was seen when the content was increased from 1 to 5 wt%. 1BCNF electrodes prepared from 1 wt% nano-sized boron oxide with PAN show a remarkable specific capacitance of 146 Fg-1 at 1Ag-1 compared to the pure CNF which is 46 Fg-1. Also, 1BCNF composite has an excellent cycle life which is more than 90 % capacity retention after 6500 cycles. The results showed that 1BCNF composite is a promising potential electrode for supercapacitor applications due to the optimized pore structure and enhanced electrical conductivity.
Инновационные ориентиры и инвестиционная активность как перспективные направления совершенствования устойчивого развития жилищно-строительного комплекса Российской Федерации
Authors: Архипов Андрей Владимирович , Камышанченко Елена Николаевна , Растопчина Юлия Леонидовна , Сивцова Надежда Федоровна
Published: September 2021

Цель: исследование инновационно-инвестиционных особенностей развития российского жилищно-строительного комплекса. Обсуждение: в ходе исследования установлено, что стратегическая модель инновационного развития строительства предполагает устойчивость инвестиций и точное описание механизмов стимулирования использования инновационных технологий. Принимая во внимание, что проблеме инвестиционной составляющей инновационного развития строительной отрасли уделяется значительное внимание в работах зарубежных и отечественных специалистов, следует отметить, что активная пози- ция государства в области развития национальной инвестиционной деятельности, в том числе инновационно-инвестиционной, направлена, в первую очередь, на создание и модернизацию отечественных производств. Результаты: обзор государственных программ и проектов поддержки жилищно-строительного комплекса в стране, оценка современного состояния и характеристика условий инновационного развития российского жилищно-строительного комплекса.
Роль региональных органов власти в поддержке малого бизнеса
Authors: Солодимова Татьяна Юрьевна
Published: September 2021

Цель: определить роль законодательной власти в развитии малого бизнеса в регионе и проанализировать полноту отдельных мер, принимаемых с целью стимулирования развития малого предпринимательства как со стороны государства, так и со стороны региональных властей. Обсуждение: теоретический анализ с использованием отдельных данных официальной статистики позволил исследовать мнения различных авторов по вопросам поддержки малого бизнеса со стороны региональных властей. Результаты: несмотря на роль, отводимую малому бизнесу в экономике как региона, так и России в целом, а также на принимаемые со стороны государства меры поддержки, наблюдается очень нестабильная картина развития малых предприятий. Отсутствие единого механизма помощи малого бизнеса не способствует его развитию.
Обеспечение продовольственной безопасности на уровне интеграции: опыт Европейского и Евразийского союзов
Authors: Шуракова Наталья Николаевна
Published: September 2021

Цель: статья посвящена выявлению особенностей обеспечения продовольственной безопасности в Европейском и Евразийском Союзах. Обсуждение: опыт Европейского Союза показывает, что интеграционным стержнем является действенная Единая аграрная политика, благодаря которой достигается продовольственная безопасность. Сельское хозяйство признается сектором, требующим особой защиты, что лоббирует высокие субсидии фермерам. Изучение опыта Евразийского Союза свидетельствует о наличии внутриинтеграционных отраслевых проблем и отсутствии согласованной аграрной политики при высоком агропродовольственном потенциале. Результаты: в ходе проведенного исследования были определены основы качественного питания, особое значение для обеспечения которого имеют внешне­ экономические связи. Сделан вывод о том, что продовольственная безопасность на современном этапе развития связана не только с обеспечением наличия и доступа к продовольствию (традиционный подход), но и с гарантией его качества и безопасности (качественный подход). Представлена авторская систематизация уровней обеспечения продовольственной безопасности. Отмечены пути укрепления Евразийской интеграции по агропродовольственной линии в целях обеспечения коллективной продовольственной безопасности стран-участниц.
nanopore nCoV-2019 sequencing protocol (RAPID barcoding, 1200bp amplicon, combined RT-PCR) v5
Authors: Pembaur Anton , Sallard Erwan , Weil Patrick , Ortelt Jennifer , Ahmad-Nejad Parviz , Postberg Jan
Published: September 2021

We established a protocol for fast, cost efficient Sars-CoV-2 sequencing with little as possible hands-on time (around 3h in total, excluding RNA extraction). The whole Sequencing can be done in one working day, including the bioinformatic pipeline. The cost per sample accumulates at around 40$, with already isolated RNA. We adapted and simplified existing workflows using the ‘midnight’ 1,200 bp amplicon split primer sets for PCR, which produce tiled overlapping amplicons covering almost all of the SARS-CoV-2 genome. Subsequently, we applied the Oxford Nanopore Rapid barcoding protocol and the portable MinION Mk1C sequencer in combination with the ARTIC bioinformatics pipeline. We tested the simplified and less time-consuming workflow on confirmed SARS-CoV-2-positive specimens from clinical routine and identified pre-analytical parameters, which may help to decrease the rate of sequencing failures. Duration of the complete pipeline was approx. 7 hrs for one specimen and approx. 11 hrs for 12 multiplexed barcoded specimens. This protocol is a modified version of Nikki Freed and Olin Silanders protocol. To get information such as Primers, visit their protocol. Nikki Freed, Olin Silander 2020. nCoV-2019 sequencing protocol (RAPID barcoding, 1200bp amplicon).doi: 10.1093/biomethods/bpaa014
[RETRACTED] Essential CBD Gummies Australia Price, Essential CBD Extract Gummies Review v1
Authors: CBD Gummies Australia Au Essential
Published: September 2021

[RETRACTED]

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A felvételi követelmény megváltozásának hatása a felsőoktatás területi rekrutációjára
Authors: Polónyi István
Published: September 2021

A 2020-as felsőoktatási felvételi jelentős visszaesés hozott mind a jelentkezők, mind a felvettek számában. A tanulmány azzal foglalkozik, hogy a létszámcsökkenés milyen hatással van a felsőoktatás területi rekrutációjára.

Az írás először bemutatja a felsőoktatási felvételi követelményekben bekövetkezett változást rámutatva, hogy az emeltszintű érettségi általánossá tétele okozta a jelentkezők, s ennek nyomán a felvettek számának csökkenését. Ezt követően a munka a felsőoktatás területi rekrutációjának három metszetét elemzi. Először a bejutási esélyek változásának kistérségi hatását vizsgálja meg, a jelentkezők és a felvettek kistérségi megoszlásának változásait bemutatva. Ezután a leghátrányosabb helyzetű kistérségek fiataljainak bekerülésének változását elemzi összehasonlítva azt a legjobb helyzetű kistérségekkel. Végül a felvételi követelmény szigorítás nyomán bekövetkezett létszámcsökkenés hatását mutatja be a felsőoktatási szféra főváros-vidék szerinti rekrutációjára.

A tanulmány befejezésül rámutat, hogy a felvételi rendszer szigorítása kedvezőtlenül hatott a hátrányos helyzetű kistérségekből a felsőoktatásba törekvő fiatalok bejutási lehetőségeire, valamint átstrukturálja az intézményrendszert is, amelynek nyomán a fővárosi intézmények dominanciája tovább növekszik.
Clinical and genetic characteristics of distal arthrogryposis caused by mutations in the PIEZO2 gene
Authors: Markova T. V. , Dadali E. L. , Nikitin S. S. , Murtazina A.  F . , Mironovich O. L. , Kanivets I.  V.
Published: September 2021

Mutations in the PIEZO2 gene, which is involved in the formation of the mechanosensitive cation channel Piezo2, can cause distal arthrogryposis type 3 (Gordon’s syndrome), type 5, and Marden–Walker syndrome. Clinical and genetic characteristics of two patients with distal arthrogryposis with autosomal dominant inheritance and one with autosomal recessive inheritance are presented. Exome sequencing in one case revealed a de novo mutation in exon 52 of the PIEZO2gene c.8238G>A (p.Trp2746*, NM_022068.3), in the second, a known deletion of three nucleotides in exon 52 of the PIEZO2 gene c.8181_8183delAGA (p Glu2727del, NM_022068.3) was found, in the third, two mutations in the compound heterozygous state – a deletion of four nucleotides leading to a shift in the reading frame in c.1863_1866delTCAG(p.Ser621fs, NM_022068) and a deletion with putative coordinates 10785050–10789339 bp, spanning 15–16 exons of the PIEZO2 gene (NM_022068; LOD 2.40). The third patient was found to have two newly detected mutations in the compound heterozygous state – a deletion of four nucleotides, leading to a shift in the reading frame in exon 14, p.1863_1866delTCAG (p.Ser621fs, NM_022068) and a deletion with assumed coordinates 10785050–10789339 b. o., (NM_022068; LOD 2.40), spanning 15–16 exons of the PIEZO2 gene. The previous assumption was confirmed that heterozygous mutations are more often localized in exon 52 of the PIEZO2 gene and disrupt the amino acid sequence of the C‑terminal region of the protein molecule, while in patients with an autosomal recessive mode of inheritance of the mutation, the N‑terminal region is more often found.
Glutaric aciduria type 1 in children. Clinical presentation of 46 cases in Russian families
Authors: Mikhailova S. V. , Saifullina E. V. , Baranova P. V. , Vorontsova V. P. , Gribov D.  I. , Zhivihina M.   V. , Slatetskaya A. N. , Magzhanov R.  V. , Samokhvalov V. A. , Virtseva M.  N. , Borscheva L.     P. , Koh E.  E. , Novikova M.   V. , Abrukova A. V. , Belyashova E.     Yu. , Gerasimenko N.    Yu. , Guseva L.     V. , Yukhimenko Zh.     V. , Nikitina N.     V. , Belyaeva T.  I. , Shkurko T.   A. , Pichkur N.   A. , Kakaulina V.     S. , Pechatnikova N.   L. , Polyakova N .  A. , Korostelev S.    A. , Pyankov D.    V. , Kanivets I.   V. , Demina N.   A. , Pyrkova E.     Yu. , Baidakova G.     V. , Kurkina M.    V. , Zakharova E.   Yu.
Published: September 2021

Background. Glutaric aciduria type 1 is an autosomal recessive disease caused by mutations in the GCDH gene, which encodes the enzyme glutaryl‑CoA dehydrogenase. Metabolic crisis in type 1 glutaric aciduria is an acute life‑threatening condition that requires careful diagnosis with a number of other conditions and the immediate initiation of pathogenetic therapy.

Materials and methods. Clinical manifestations, neuroimaging characteristics of the disease were studied in 46 patients with diagnosed glutaric aciduria type 1 confirmed by biochemical and molecular genetic methods. Methods: gas chromatography with mass spectrometry, tandem mass spectrometry, Sanger sequencing, chromosomal microarray analysis of the exon level.

Results and discussion. A retrospective analysis of anamnestic and clinical data was carried out, and the nature and age of disease manifestation, provoking factors, a spectrum of clinical manifestations and neuroimaging data were assessed.

Conclusion. How initiated treatment prevents progression of neurological symptom relief and patient adaptation. With the help of the goal, it is necessary to inform pediatricians, neurologists and neuroradiologists about this feature of the course of glutaric aciduria type 1 in order to increase the clinical alertness of this disease.
MODEL OF PHYSICAL PROCESSES IN PRIMARY AND SECONDARY CONVERTERS OF THE DETECTOR
Authors: Banzak O.V. , Sieliykov A.V. , Dobrovolskaya S.V. , Konovalenko O.I.
Published: September 2021

The level of development and application of radiation technologies is largely determined by the state of nuclear instrumentation. The advent of modern semiconductor sensors for the first time linked nuclear instrumentation and electronics into a single complex - semiconductor detector. It combines semiconductor primary converter of ionizing radiation (sensor), a secondary converter of information from the sensor (electronics) and software for processing this information, interconnected in terms of the problem being solved and parameters. The structural diagram of detector consists of two main parts: a primary converter of ionizing radiation (IR) energy into an electrical signal - a sensor; secondary converter of this electrical signal. The characteristics of detector are mainly determined by the physical properties of the semiconductor crystal as a sensitive element of the primary converter, as well as by the features of the process of recording an electrical signal.

The process of registering an IR consists in converting a non-electrical quantity characterizing it into an electrical signal. In other words, this converts one type of energy - the energy of IR - into another, more convenient for processing and accumulating information. A current or voltage pulse arises in the radiation sensor directly as a result of ionization of its active medium - a semiconductor; this pulse carries extensive information. First of all, it is correlated with the moment of time of the nuclear process. In addition, the pulse marks the fact that radiation is emitted within the solid angle at which the sensor is visible from the source. Pulse amplitude is often a measure of the energy loss of radiation in the sensor. The pulse shape is different for different types of radiation, as well as for different areas and angles of radiation hitting the sensor. In this work, a model of a gamma radiation detector has been created as a single system of primary and secondary converters. It contains physical analysis and analytical presentation of the processes occurring in the CdZnTe-sensor and electronic preamplifier. It is shown that the charge collection in the sensor differs in time, which leads to a spread of signal pulses in duration and amplitude. In this regard, model shows the need to use a charge-sensitive preamplifier. The main advantage of the model is solution to problem of optimizing signal-to-noise ratio in detector.
Closed craniocerebral injury formation according to an indirect mechanism: a case from expert practice
Authors: Ulyankin Vladislav E. , Kupriyanov Alexey Yu. , Zyubina Ekaterina A. , Machinsky Petr A.
Published: September 2021

Background: Approximately, 50 thousand die (i.e., about 10%) out of the 600 thousand people with a head injury. Literature examples reported some cases with brain damage with membranes in closed craniocerebral trauma formed by an indirect mechanism without direct contact of blunt solid objects in the head, which is characteristic of impulse trauma. Case presentation: In our practice, an unusual case of an indirect closed craniocerebral trauma with a fatal outcome resulting from a road traffic accident was encountered. The forensic medical examination of the corpse established a traumatic brain injury that formed without direct contact with blunt solid objects in the head. Traumatic brain injury formation by an impulse mechanism is rare in forensic medical practices; therefore, each case of such an injury is of certain interest, both in practical and scientific terms.
Conclusion: The impulse mechanism of head trauma, combined with the shock mechanism in road traffic accidents, is much more common than is currently believed. The bleeding source in such cases is often the venous vessels of the cerebral hemispheres, which flow into the sagittal sinus of the dura mater.
Combined chest and abdominal trauma in pedestrians injured during car accidents
Authors: Indiaminov Sayit I. , Pardaev Saidkosim N. , Kim Antonina A.
Published: September 2021

Background: Severe injury associated with road traffic injuries and falls from heights is highly global health, social, and economic problem worldwide. The main contingent of victims of concomitant injury (СI) is mostly at working age. Materials and methods: A forensic medical examination was performed in 215 corpses of persons killed in moving car collisions, wherein 173 were males and 42 females. The victims were between 14 and 75 years old. Results: Injuries of two or more parts of the body with fractures of the limb bones (55.8%) and head, chest, and abdominal CI (23.3%) prevail in pedestrians who died in car collisions. CI composed of structural damages of the chest and chest cavity organs in 85.6% of cases. Rib fractures were detected in 57.7% of cases; fractures in the midclavicular and axillary lines predominated in localization. Structural damages of the abdominal cavity organs and tissues are 71.0% of the abdominal CI in pedestrians. In addition, 80.8% of dead pedestrians showed signs of organ and tissue injuries with pronounced hemorrhages in the suspension apparatuses, walls, and parenchyma of organs. Along with hemorrhages, a violation of the anatomical integrity of organs, mainly the liver and spleen, was found in 23.2% of cases. Conclusion: The outlined nature of structural damage of the chest and chest and abdominal cavity organs establish the possibility of their formation in the third phase of car injury the fall of the injured on the road surface. Traumatic (pleuropulmonary), hemorrhagic shock, and hemorrhagic pneumothorax were the main causes of injuries at the prehospital stage.
Gıda Reklamlarına Görünmez Sınırlama: Akar Bant Uyarıları Üzerine Nitel Bir Araştırma
Authors: ÇETİNKAYA Enes , DEREN VAN HET HOF Seçil
Published: September 2021

Bu çalışma Türkiye’deki reklam düzenleme süreçlerinin etkinliğini obezite sorunu bağlamında ele
almaktadır. Reklamların insanlar üzerinde bıraktığı etkiler, insan ve halk sağlığı sorunu ile ilişkilendirilen
çeşitli ürünlerin ticari tanıtımının kamusal ya da sektörel düzenlemelere tabi kılınmasını gerektirmiştir.
Obezite son yıllarda bir halk sağlığı sorunu ve hatta salgın olarak kabul edilmekte olup obezitenin
yayılmasında “aşırı tüketimi tavsiye edilmeyen” gıda reklamlarının rolü olduğu düşünülmektedir.
Bu nedenle, Türkiye’de bu tür gıda reklamlarında Radyo Televizyon Üst Kurulu (RTÜK) tarafından
belirlenen uyarı mesajlarına akar bant şeklinde yer verilmesi düzenlemesi getirilmiştir. Ancak bu akar
bant uyarılarının etkisi sorgulanmamıştır. Bu makalede, derinlemesine görüşmeler ile akar bantlarda yer
alan uyarıların tüketiciyi etkileme kapasitesi sorunsallaştırılmaktadır. Makalede nitel yöntem uygulanmış,
çeşitli araştırmalara göre hane halkının yiyecek tüketiminde birincil karar verici oldukları görülen kadın
tüketicilere kartopu örneklem ile ulaşılmış ve 11 görüşme gerçekleştirilmiştir. Çevrimiçi gerçekleştirilen
görüşmelerde görüşmeciye bir bağlantı gönderilerek 2 dakikalık bir reklam bandı izlettirilmiş, ardından
da kayıt onayları alınarak görüşme gerçekleştirilmiştir. Görüşme metinleri çözümlendiğinde, akar bant
uyarılarının fark edilmediği anlaşılmış, fark edilmemesinin temel nedeninin yazıların hızı ve boyutu olduğu
belirlenmiştir. Bu bağlamda değerlendirildiğinde fark edilmeyen mesajların hedef kitleyi etkilemesinin
mümkün olmadığı gözlenmiştir. Sonuç olarak reklam düzenlemeleriyle getirilen akar bant uygulamasının,
aşırı tüketimi tavsiye edilmeyen gıdalara ilişkin farkındalık yaratarak obeziteyi önlemesi konusunda hiçbir
işlevinin olmadığı tespit edilmiştir.
Peningkatan Keterampilan Menulis Narasi melalui Model Pembelajaran SAVI Berbantuan Media CD Interaktif
Authors: Rakhmawati Ayu Vidya , Handayanto Supriyono Koes , Gipayana Muhana
Published: September 2021

Abstract: This paper to describe about learning process to improve the skills of writing narrative with the help through SAVI (Somatic, Auditory, Visual, Intelectual) learning model and media CD interactive. The learning process is carried out in three stages namely pre writing, writing, and post writing, with involving the whole activities that include somatic, auditory, visual, and intellectual by using the media cd interactive. This research use qualitative approach type PTK collaboration. The research conducted in two cycles. The result show everage score of student writing narrative same 59 in the first cycle and increase same to 72 in the second cycle.

Abstrak: Artikel ini bertujan untuk mendeskripsikan tentang proses pembelajaran untuk meningkatkan keterampilan menulis narasi yang dibantu melalui model pembelajaran SAVI (Somatic, Auditory, Visual, Intelectual) berbantuan media CD interaktif. Proses pembelajaran dilaksanakan dalam tiga tahap, yaitu pra-menulis, menulis, dan pasca menulis yang melibatkan keseluruhan aktivitas, meliputi somatik, auditori, visual, dan intelektual yang dibantu dengan penggunaan media CD interaktif. Penelitian ini menggunakan pendekatan kualitatif jenis PTK kolaborasi. Penelitian ini dilaksanakan selama dua siklus. Hasil penelitian menunjukkan bahwa pada siklus I rata-rata nilai menulis narasi sebesar 59 dan mengalami peningkatan pada siklus II dengan nilai sebesar 72.
Penggunaan Media Audiovisual pada Model Inkuiri Terbimbing terhadap Keterampilan Proses Sains dan Penguasaan Konsep IPA
Authors: Magfirah Ainun , Hidayat Arif , Mahanal Susriyati
Published: September 2021

Abstract: This research was aimed to know the use of audiovisual media in a guided inquiry model of science processskills and mastery of students' concepts in science subjects. The low level of science process skills and mastery of concepts that exist today, becomes the urgency of this research. in this study, the type of research used was quasi-experimental research using two learning classes as research samples with different treatments. The sample is divided into experimental class and control class with simple random sampling technique. The analysis showed that there were significant differences in the experimental class with media use audiovisual in the guided inquiry model with the average value of science process skills and mastery of concepts is higher than the control class.

Abstrak: Penelitian ini bertujuan untuk mengetahui penggunaan media audiovisual pada model inkuiri terbimbing terhadap keterampilan proses sains dan penguasaan konsep siswa pada mata pelajaran IPA. Rendahnya keterampilan proses sains dan penguasaan konsep saat ini, menjadi urgensi penelitian ini. Jenis penelitian yang digunakan merupakan penelitian kuasi eksperimen dengan menggunakan dua kelas belajar sebagai sampel penelitian dengan perlakuan yang berbeda. Sampel tersebut dibedakan menjadi kelas eksperimen dan kelas kontrol dengan simple random sampling. Hasil kajian menghasilkan ada perbedaan yang signifikan pada kelas eksperimen dengan penggunaan media audiovisual pada model inkuiri terbimbing dengan nilai rata-rata Keterampilan Proses Sains dan penguasan konsep lebih tinggi dibandingkan kelas kontrol.
Proses Berpikir Siswa dalam Menyelesaikan Soal Higher Order Thinking Skills Berdasarkan Pemahaman Konseptual dan Prosedural
Authors: Astuti Puji , Qohar Abdul , Hidayanto Erry
Published: September 2021

Abstract: This study aims to describe the thinking process of students in solving Higher Order Thinking Skills problems based on conceptual and procedural understanding. This type of research is descriptive research. The subject of this study was the eighth-grade students of Ma’arif 3 Islamic Middle School Malang. The results of the study were obtained (1) Based on the conceptual understanding of the subject did not meet the indicators presenting concepts in various forms of mathematics, but fulfilling the indicators rewrite the concepts that had been studied and could apply the concepts algorithmically. (2) Based on procedural understanding the subject meets the indicators of choosing the right procedure in solving the problem, but it is not appropriate to know when and how to use the procedure and apply the procedure chosen to solve the problem.

Abstrak: Penelitian ini bertujuan untuk mendeskripsikan proses berpikir siswa dalam menyelesaikan soal Higher Order Thinking Skills berdasarkan pemahaman konseptual dan prosedural. Jenis penelitian ini adalah penelitian deskriptif. Subjek penelitian ini adalah siswa kelas VIII SMP Islam Ma’arif 3 Malang. Hasil penelitian diperoleh (1) berdasarkan pemahaman konseptual subjek belum memenuhi indikator mempresentasikan konsep dalam berbagai bentuk matematika, tetapi memenuhi indikator menuliskan kembali konsep yang telah dipelajari dan dapat menerapkan konsep secara algoritma; (2) berdasarkan pemahaman prosedural subjek memenuhi indikator memilih prosedur yang tepat dalam menyelesaikan masalah, namun kurang tepat dalam mengetahui kapan dan bagaimana menggunakan prosedur tersebut dan mengaplikasikan prosedur yang dipilih untuk memecahkan masalah.
Strategi Pembelajaran Menulis Puisi Reflektif untuk Siswa SMA Kelas X
Authors: Purbarani Etsa , Ghazali Abdus Syukur , Widiati Nita
Published: September 2021

Abstract: Writing poetry learning in school tends to be mechanistic and less direct students in creative process that cause difficulty and decrease students’ motivation on writing poetry. Therefore, the researcher develops poetry writing learning strategy, that is learning strategy of writing reflective poetry which is packaged in a guidebook designed for teachers. Based on those explanations, this development aims to (1) developing products in the form of learning strategies to write reflective poems, (2) develop a guide of the implementation of a reflective poetry writing strategy that designed for teachers, and (3) reported the product feasibility test of reflective poetry writing strategy.

Abstrak: Selama ini, pembelajaran menulis puisi di sekolah cenderung bersifat mekanistik dan kurang mengarahkan siswa untuk berproses kreatif. Hal tersebut menjadikan siswa mengalami kesulitan dan penurunan motivasi dalam menulis puisi. Oleh karena itu, dikembangkan strategi pembelajaran menulis puisi, yaitu strategi pembelajaran menulis puisi reflektif yang dikemas dalam bentuk buku panduan dan ditujukan untuk guru. Berdasarkan paparan tersebut, penelitian pengembangan ini bertujuan untuk (1) mengembangkan produk berupa strategi pembelajaran menulis puisi reflektif, (2) mengembangkan panduan penerapan strategi pembelajaran menulis puisi reflektif yang penggunaannya ditujukan untuk guru, dan (3) melaporkan uji kelayakan produk strategi pembelajaran menulis puisi reflektif.
Miskonsepsi Konsep Gerak Satu dan Dua Dimensi Siswa SMA
Authors: Nisa’ Faizatun , Yuliati Lia , Mufti Nandang
Published: September 2021

Abstract: Aim of this study is to explore Senior High School student’s concepts understanding on one and two dimensional motion. This study is quantitave non-experiment using survey. The instrument was multiple choice test contains concepts understanding on one and two dimensional motion. Sample of this study are 113 students from grade XI and XII SMA Negeri in Bojonegoro. Result shows, conceptual understanding of students on one and two dimensional motion is low and misconception are found.
Abstrak: Penelitian ini bertujuan mengeksplorasi penguasaan konsep gerak satu dan dua dimensi siswa SMA. Penelitian menggunakan pendekatan kuantitatif non-eksperimen dengan metode survei. Instrumen pengukuran berupa soal tes penguasaan konsep berbentuk pilihan ganda. Tes diberikan pada 113 siswa yang terdiri dari kelas XI dan XII SMA di Bojonegoro. Hasil penelitian didapatkan penguasaan konsep gerak satu dan dua dimensi siswa rendah dan ditemukan kesalahan konsep.
Analisis Berpikir Kreatif Siswa Berkemampuan Matematika Rendah Dalam Menyelesaikan Ill-Structured Problem
Authors: Al - Ghofiqi Maulana , Irawati Santi , Rahardi Rustanto
Published: September 2021

Abstract: The purpose of this study was to find out in detail the creative thinking of students with low mathematical abilities in solving ill-structured problems. This type of research is a case study, tconducted at SMPN 4 Waru (State Junior High School 4 Waru), Sidoarjo. 16 Students complete the ill-structured problem test, then subjects are chosen who have a level of creative thinking in the creative category and have low mathematical abilities. The results of the study showed students fulfilled the fluency aspect based on students' ability to provide at least two correct answers and were able to explain it. Flexibility aspects are fulfilled based on students' abilities in each answer written using different ideas. While the novelty aspect is not fulfilled because students do not give any unusual answers.
Abstrak: Tujuan penelitian ini adalah untuk menganalisis berpikir kreatif siswa berkemampuan matematika rendah dalam menyelesaikan ill-structured problem. Jenis penelitian ini yaitu studi kasus, dilaksanakan di SMPN 4 Waru, Sidoarjo. 16 Siswa menyelesaikan tes ill-structured problem, selanjutnya dipilih subjek yang mempunyai level berpikir kreatif dalam kategori kreatif dan mempunyai kemampuan matematika rendah. Hasil penelitian menunjukkan siswa memenuhi aspek fluency berdasarkan kemampuan siswa dalam memberikan minimal dua jawaban benar serta mampu menjelaskannya. Aspek flexibility terpenuhi berdasarkan kemampuan siswa pada setiap jawaban yang dituliskan menggunakan ide yang berbeda, sedangkan aspek novelty tidak terpenuhi karena siswa tidak memberikan satu pun jawaban tidak biasa.