bluuebunny/crossref_metadata_2025 huggingface dataset:
Disparities in cancer risk management among BRCA carriers across a diverse sample of young black, Hispanic, and non-Hispanic white breast cancer survivors.
Authors: Pal Tuya , Cragun Deborah , Lewis Courtney , Bonner Devon , Camperlengo Lucia P , Vadaparampil Susan Thomas
Published: May 2017

LBA1504

Background: Rates of risk-reducing bilateral mastectomy (RRM) or risk-reducing prophylactic oophorectomy (RRSO) among BRCA carriers are based on studies of non-Hispanic whites (NHW), with little known among blacks or Hispanics. Methods: A population-based sample of NHW, black, and Hispanic women diagnosed with invasive BC < age 50 in 2009-12 were recruited through the Florida State Cancer Registry and completed a baseline survey. Among the subset of BRCA carriers, we compared risk management for: 1) ovarian cancer (OC) through RRSO; and 2) BC through RRM or MRI screening, by calculating percentages and conducting logistic regression to control for other variables. Results: Of 1570 participants, 884 reported BRCA testing. Of the 91 BRCA carriers, 1) RRSO was 71% (36/51) among NHW, 32% (9/28) among blacks, and 83% (10/12) among Hispanics; 2) either breast MRI or RRM was 98% (50/51) among NHW, 85.7% (24/28) among blacks, and 100% (12/12) among Hispanics. BC risk management modality differed across groups, with lower rates of RRM among blacks (67%) compared to Hispanics (83%) and NHW (94%). After controlling for age at enrollment, time since diagnosis, income, family history of BC, family history of OC and private insurance at diagnosis: 1) Hispanics and NHW were significantly more likely than blacks to have RRSO (p = 0.01 and 0.02 respectively); and 2) NHW were also significantly more likely than blacks to have RRM (p = 0.03), although Hispanic race approached statistical significance (p = 0.10). Conclusions: The racial disparities in uptake of RRSO observed among blacks is particularly concerning given that RRSO is strongly recommended as the main OC prevention option due to the absence of effective OC early detection methods. The benefit from genetic testing comes from uptake of cancer risk management options, rather from testing itself. Future studies are needed to better understand and develop methods to improve cancer risk management practices across all populations.
Anti-CD19 chimeric antigen receptor T cells preceded by low-dose chemotherapy to induce remissions of advanced lymphoma.
Authors: Kochenderfer James , Somerville Robert , Lu Tangying , Shi Victoria , Yang James C. , Sherry Richard , Klebanoff Christopher , Kammula Udai S. , Goff Stephanie L. , Bot Adrian , Rossi John , Sherman Marika , Perez Arianne , Xue Allen , Feldman Tatyana A. , Friedberg Jonathan W. , Roschewski Mark J. , Feldman Steven , McIntyre Lori , Rosenberg Steven A.
Published: May 2017

LBA3010

Background: T cells genetically-modified to express chimeric antigen receptors (CARs) targeting CD19 have potent activity against a variety of B-cell malignancies. Chemotherapy is administered prior to CAR T cells because depletion of recipient leukocytes enhances the anti-malignancy efficacy of adoptively-transferred T cells; an increase in serum interleukin (IL)-15 is one mechanism for this enhancement. Previously, we (Kochenderfer et al. Journal of Clinical Oncology, 2015) and others have reported patients treated with high-dose chemotherapy prior to anti-CD19 CAR T-cell infusions. This report describes treatment of 22 patients with low-dose conditioning chemotherapy followed by infusion of anti-CD19 CAR T-cells. Methods: Eighteen of 22 treated patients received 300 mg/m2 of cyclophosphamide (cy) daily for 3 days; 4 patients received 500 mg/m2 of cy on the same schedule. All patients received fludarabine 30 mg/m2daily for 3 days on the same days as cy. Patients received a single dose of CAR T cells 2 days after completion of chemotherapy. Blood CAR T cells and serum cytokines were analyzed in all patients. Results: Nineteen patients with various subtypes of diffuse large B-cell lymphoma (DLBCL) had the following responses: 8 CR, 5 PR, 2 SD, and 4 PD. One patient with mantle cell lymphoma obtained a CR. Two patients with follicular lymphoma both obtained CRs. Durations of response currently range from 1 to 20 months; 10 remissions are ongoing. All but 4 patients had either chemotherapy-refractory lymphoma or lymphoma that had relapsed after autologous stem cell transplant. The most prominent toxicities were various neurological toxicities. Other toxicities included fever and hypotension. The median peak blood CAR+ cell level was 47/μL (range 4-1217/μL). Patients obtaining CRs or PRs had higher peak blood CAR+ cell levels than patients experiencing SD or PD. The mean serum IL-15 level was 4 pg/mL before the conditioning chemotherapy and 32 pg/mL after chemotherapy (P < 0.0001). Conclusions: Anti-CD19 CAR T cells can induce remissions of advanced B-cell lymphoma when administered after low-dose chemotherapy. In the near future, CAR T cells will likely be a standard therapy for lymphoma. Clinical trial information: NCT00924326.
Atezolizumab (atezo) as first-line (1L) therapy in cisplatin-ineligible locally advanced/metastatic urothelial carcinoma (mUC): Primary analysis of IMvigor210 cohort 1.
Authors: Balar Arjun Vasant , Galsky Matt D. , Loriot Yohann , Dawson Nancy Ann , Necchi Andrea , Srinivas Sandy , Joseph Richard Wayne , Vaishampayan Ulka N. , Sridhar Srikala S. , Quinn David I. , Drakaki Alexandra , Duran Ignacio , Rosenberg Jonathan E. , Powles Thomas , Hoffman-Censits Jean H. , Cui Na , Mariathasan Sanjeev , Thastrom Ann Christine , Abidoye Oyewale O. , Bajorin Dean F.
Published: May 2017

LBA4500

Background: Cisplatin-based chemo is a standard 1L treatment (tx) for mUC and the only tx that prolongs OS; however, age or comorbidities render many pts ineligible, and 30-50% receive no tx. Atezo (MPDL3280A) is active and well tolerated in platinum-treated mUC, justifying testing atezo as 1L tx in cisplatin-ineligible pts. Methods: Pts were chemo naive in the metastatic setting and cisplatin ineligible (renal [GFR > 30 but < 60 mL/min]/hearing impairment, ≥ G2 peripheral neuropathy [PN] or ≥ ECOG PS2). Atezo 1200 mg was given IV q3w until PD (RECIST v1.1). Centrally assessed PD-L1 on tumor infiltrating immune cells (IC; SP142 IHC assay) was scored IC2/3, 1 or 0. The primary efficacy endpoint was confirmed ORR assessed per RECIST v1.1 (central independent review facility) using a data cutoff of Sep 14, 2015. Results: 119 efficacy/safety-evaluable pts of any PD-L1 IC had a median age of 73 y: 21% ≥ 80 y. 18% had prior systemic tx (21% [neo]adjuvant); 10% had radiotherapy. 66% had visceral mets. 71% had CrCl < 60 mL/min; 13% had hearing loss ≥ 25 dB; 6% had prior PN ≥ G2; 20% had ECOG PS2. ORR was 19% (95% CI 13-28; 5% CR), and responses occurred in all IC subgroups (Table; includes DCR/PFS/OS) and in pts with poor prognostic factors. 22/23 responses were ongoing with mDOR not reached. Median follow-up was 8.5 mo (range 0.2-14.3); median tx duration was 15 wk. Atezo was generally well tolerated. Tx-related all-G and G3-4 AEs were seen in 64% and 12% of pts, respectively. Related all-G AEs ≥ 10% included fatigue, pruritus, diarrhea. 1 G5 related AE occurred (sepsis). 3% had a G3-4 immune-mediated AE. Conclusions: Atezo has clinically meaningful activity in 1L cisplatin-ineligible mUC pts, and preliminary OS is encouraging. The durable nature of response and favorable AE profile makes this an attractive alternative to chemo. NCT02108652. Clinical trial information: NCT02108652. [Table: see text]
Patient-reported outcomes from MA.17R: A randomized trial of extending adjuvant letrozole for 5 years after completing an initial 5 years of aromatase inhibitor therapy alone or preceded by tamoxifen in postmenopausal women with early-stage breast cancer.
Authors: Lemieux Julie , Goss Paul E. , Parulekar Wendy R. , Ingle James N. , Pritchard Kathleen I. , Robert Nicholas J. , Muss Hyman , Gralow Julie , Strasser-Weippl Kathrin , Brundage Michael Donald , Whelan Kate , Tu Dongsheng , Whelan Timothy Joseph
Published: May 2017

LBA506

Background: MA.17R is a Canadian Cancer Trials Group (CCTG) led phase III randomized controlled trial comparing letrozole to placebo after 5 years of aromatase inhibitor (AI) as adjuvant therapy for hormone-receptor positive breast cancer. The primary endpoint was disease-free survival. Quality of life (QOL) was a secondary endpoint. Methods: QOL was measured with the SF-36 (2 summary scores and 8 domains) and menopause-specific QOL (MENQOL) (4 symptom domains) at baseline and every 12 months (mo) up to 60 mo. QOL assessment was mandatory for CCTG centres but optional to centres in other groups. Mean change scores from baseline were calculated at 12 and 36 mo. Between-arm differences were assessed with the Wilcoxon test. Results: 1918 patients were randomized and 1428 patients completed the baseline QOL assessment. Compliance with QOL measures was over 85%. Baseline summary scores for SF-36 physical (PCS, 47.5 for letrozole and 47.9 for placebo) and mental (MCS, 55.5 for letrozole and 54.8 for placebo) were close to population norms (50). No differences were seen between groups in mean change scores for the SF-36 PCS and MCS and the other 8 QOL domains. Patients randomized to letrozole reported worse vasomotor symptoms (12 mo p = 0.02, 36 mo p = 0.03) and worse sexual functioning (12 mo p = 0.01, 36 mo p = 0.01). Further analyses with follow up to 60 months will be presented. Conclusions: No differences were seen in overall QOL measured by the SF 36 summary measures between letrozole and placebo groups. Differences existed for vasomotor symptoms and sexual functioning which were worse in the letrozole group and attributed to improvements in mean scores seen for women randomized to placebo. The data indicate that continuation of AI therapy after 5 years prior treatment is not associated with a deterioration of overall QOL. Treatment related vasomotor and sexual functioning alterations occur with ongoing treatment. Clinical trial information: NCT00754845.
Therapy of relapsed/refractory metastatic triple-negative breast cancer (mTNBC) with an anti-Trop-2-SN-38 antibody-drug conjugate (ADC), sacituzumab govitecan (IMMU-132): Phase II results.
Authors: Bardia Aditya , Diamond Jennifer Robinson , Messersmith Wells A. , Mayer Ingrid A. , Isakoff Steven J. , Abramson Vandana Gupta , Berlin Jordan , Starodub Alexander , O'Shaughnessy Joyce , Kalinsky Kevin , Moroose Rebecca L. , Shah Nikita C. , Juric Dejan , Shapiro Geoffrey , Guarino Michael J. , Ocean Allyson J. , Wilhelm Francois , Sharkey Robert M. , Goldenberg David M. , Vahdat Linda T.
Published: May 2017

LBA509

Notice of Retraction: “Therapy of relapsed/refractory metastatic triple-negative breast cancer (mTNBC) with an anti-Trop-2-SN-38 antibody-drug conjugate (ADC), sacituzumab govitecan (IMMU-132): Phase II results.” ASCO's Confidentiality Policy requires that abstracts be considered confidential and embargoed from the time of submission until the findings have been publicly released in conjunction with the ASCO Annual Meeting. Abstract LBA509, published in the 2016 ASCO Annual Meeting Proceedings Part II, violated this policy and was retracted from publication and presentation at the 2016 ASCO Annual Meeting.
Exploration of the ASCO and ESMO Value Frameworks for Antineoplastic Drugs
Authors: Becker Daniel J. , Lin Daniel , Lee Steve , Levy Benjamin P. , Makarov Danil V. , Gold Heather T. , Sherman Scott
Published: May 2017

Purpose:

In 2015, both ASCO and the European Society for Medical Oncology (ESMO) proposed frameworks to quantify the benefit of antineoplastic drugs in the face of rising costs. We applied these frameworks to drugs approved by the US Food and Drug Administration over the past 12 years and examined relationships between costs and benefits.

Methods:

We searched FDA.gov for drugs that received initial approval for solid tumors from 2004 to 2015 and calculated the ASCO Net Health Benefit version 2016 (NHB16) and 2015 (NHB15) and the ESMO Magnitude of Clinical Benefit Scale scores for each drug. We calculated descriptive statistics and explored correlations and associations among benefit scores, cost, and independent variables.

Results:

We identified 55 drug approvals supported by phase II (18.2%) and III (81.8%) trials, with primary outcomes of overall survival (36.4%), progression-free survival (43.6%), or response rate (20.0%). No significant association was found between NHB16 and year of approval ( P = .81), organ system ( P = .20), or trial comparator arm ( P = .17), but trials with progression-free survival outcomes were associated with higher scores ( P = .007). Both NHB15 and Magnitude of Clinical Benefit Scale scores were approximately normally distributed, but only a moderate correlation existed between them ( r = 0.40, P = .006). No correlation between benefit score and cost (NHB16, r = 0.19; ESMO, r = −0.07) was found. Before 2010, two (15.3%) of 13 approved drugs exceeded $500/NHB point × month compared with 10 (25.0%) of 40 drugs subsequently approved.

Conclusion:

Our analysis of the ASCO and ESMO value frameworks illuminates the heterogeneous benefit of new medications and highlights challenges in constructing a unified concept of drug value. Drug benefit does not correlate with cost, and the number of high cost/benefit outliers has increased.
Relationship between Crystal Structures and Thermoluminescence Spectra of Gamma-Irradiated Shells of Shellfish Measured with a Multichannel Fourier-Transform Luminescence Spectrometer
Authors: Shonaka Moe , Ishii Hiroshi , Hironiwa Takayuki , Akai Nobuyuki , Nakata Munetaka
Published: May 2017

Thermoluminescence spectra of gamma-irradiated shells of oysters, scallops, mussels, littleneck clams, and freshwater clams are measured with a multichannel Fourier-transform luminescence spectrometer. Oysters, scallops, and mussels isothermally heated at 200 °C show strong luminescence due to the electronic transition of Mn2+, which is included as an impurity in shells and excited to a metastable state by gamma-ray irradiation. Littleneck clams and freshwater clams show very weak thermoluminescence under the same experimental conditions and show strong thermoluminescence owing to phase transition when they are heated at 450 °C before gamma-ray irradiation. The phase transition of the crystal structures from aragonite to calcite is monitored by infrared spectroscopy.
Measuring and Understanding Brand Value in a Dynamic Model of Brand Management
Authors: Borkovsky Ron N. , Goldfarb Avi , Haviv Avery M. , Moorthy Sridhar
Published: May 2017

We develop a structural model of brand management to estimate the value of a brand to a firm. In our framework, a brand’s value is the expected net present value of future cash flows accruing to a firm due to its brand. Our brand value measure recognizes that a firm can change its brand equity by investing in advertising. We estimate quarterly brand values in the stacked chips category for the period 2001–2006 and explore how those values change over time. Comparing our brand value measure to its static counterpart, we find that a static measure, which ignores advertising and its ability to affect brand equity dynamics, yields brand values that are artificially high and that fluctuate too much over time. We also explore how changing the ability to build and sustain brand equity affects brand value. At our estimated parameterization, if brand equity were to depreciate more slowly, or if advertising were more effective at building brand equity, then brand value would increase. However, counterintuitively, we find that when the effectiveness of advertising is sufficiently high, increasing the rate at which brand equity depreciates can increase the value of a firm’s brand, even as it reduces the value of the firm overall.

Data and the online appendix are available at https://doi.org/10.1287/mksc.2016.1020 .
An Experimental Investigation of Managing Quality Through Monetary and Relational Incentives
Authors: Davis Andrew M. , Hyndman Kyle
Published: May 2017

We investigate the efficacy of monetary and relational incentives for managing the quality of a product in a two-tier supply chain. In our setting, a retailer offers a supplier contract terms for a product, where the product can be low or high quality. The supplier can choose to exert high effort, which is costly but guarantees high quality, or low effort, which does not assure high quality with certainty. We compare how monetary incentives, such as a bonus that is paid to the supplier when high quality is received by the retailer, and relational incentives, such as the two parties engaging in a long-term relationship where there is the threat of punishment, affect overall quality and supply chain efficiency. Two of our primary results suggest that (1) relational incentives improve both quality and supply chain efficiency, regardless of whether a monetary incentive is present, and (2) when relational incentives are present, the impact of adding monetary incentives is nonmonotonic: less efficient monetary incentives appear to crowd out the benefits of relational incentives leading even to a reduction in supply chain efficiency, whereas more efficient monetary incentives actually complement relational incentives and lead to significant increases in both quality and supply chain efficiency. We then proceed by demonstrating that a behavioral model of fairness can organize the data quite well.

Data are available at https://doi.org/10.1287/mnsc.2016.2716 .

This paper was accepted by Serguei Netessine, operations management.
Diabetes series, 6. Prevention and management of diabetic foot problems
Authors: Nazarko Linda
Published: May 2017

Diabetes mellitus (DM) increases the risk of foot problems and the person with diabetes is at risk of major complications, including ulcers and amputations. A person with DM is 30 times more likely to require an amputation than a person without diabetes ( Khanolkar et al, 2008 ). Every day, 20 people with diabetes have a lower limb amputation ( Public Health England, 2016 ).

Simple interventions such as smoking cessation, inspecting feet daily, seeking help if there are any concerns and wearing suitable footwear can reduce the risk of ulcers and amputations and improve quality of life.

This article aims to educate the healthcare assistant on the reasons why people with diabetes develop foot ulcers and to enable the healthcare assistant to provide appropriate care and support to people with diabetes.
Nursing students' experiences of mentorship in their final placement
Authors: Thomson Robert , Docherty Angie , Duffy Raymond
Published: May 2017

Aim:

The aim of this study was to explore final-year students' experiences of the mentorship role in their final placement and, in particular, to establish their expectations of the mentorship role, as well as their support and supervision needs.

Method:

Seven final-placement students were recruited from one Scottish university, using purposive sampling. Heideggerian phenomenology was chosen as the underpinning philosophical approach because of its emphasis on the ‘lived experience’. Data were generated using unstructured interviews and analysed using a modified version of Colaizzi's procedural steps.

Results:

Five themes emerged from the data: ‘being more independent’, ‘support’, ‘belongingness’, ‘feedback’ and ‘anticipatory anxiety’.

Discussion:

Participants who had a positive experience of mentorship were exposed to a ‘good’ learning environment. As a result, they felt supported, received adequate opportunities to practise management skills, had a sense of ‘belonging’ within the nursing team and had regular feedback. Those who had a negative experience complained of not getting the opportunity to develop essential management skills and being dismissed for trying to be proactive. In addition, feedback was reported to be lacking. This experience resulted in reduced confidence levels, which left them feeling unprepared for the transition to registered nurse.

Conclusion:

The clinical learning environment itself and support from the mentor are key factors that influence student preparation for registration. Without this level of support, students may be left feeling unprepared to deal with the transition.
How amendments to the Mental Health Act 1983 will change police powers
Authors: Griffith Richard
Published: May 2017

Richard Griffith, Senior Lecturer in Health Law at Swansea University, considers the impact on nursing practice of amendments to police powers under the Mental Health Act 1983 introduced by the Policing and Crime Act 2017
Understanding the global causes and costs of patient harm
Authors: Tingle John
Published: May 2017

John Tingle, Reader in Health Law at Nottingham Trent University, discusses the Organisation for Economic Co-operation and Development's report on the economics of patient safety
Urinary catheter-related visits to the emergency department and implications for community services
Authors: Ansell Tiziana , Harari Danielle
Published: May 2017

Thousands of patients live with urinary catheters and the potential complications deriving from long-term use. Disjointed community services may result in patients attending the emergency department (ED) to manage catheter complications. Aim: to conduct a service review of catheterised patients attending the ED of a large London hospital; to describe incidence, reasons for attendance and cost to inform future planning for out-of-hospital care. Method: a catheter collaborative, consisting of multidisciplinary health professionals and patients, formulated survey questions. Patients were identified from the electronic patient record by searching for the code ‘urological complaint’. One month of clinical records were retrospectively reviewed and analysed using descriptive statistics. Results: 287 patients attended the department with urological complaints: 41 (14%) had urinary catheter problems, of these 24 (59%) patients were discharged and 17 (41%) were admitted for further treatment. Stays in ED varied from 1 hour 13 minutes to 17 hours (mean = 4.8 hours). A total of 9 patients (38%) were sent home during antisocial hours (9 pm to 7 am), 4 patients were discharged between midnight and 2 am. Patients admitted had mean stays of 4.11 days. Most admissions were short term for intravenous (IV) treatments; 3 patients were hospitalised for 20 days. A total of 14 patients (34%) were diagnosed with catheter-related infections: 11 (79%) had bladder infections and 3 (21%) had septicaemia. All 14 patients (100%) had urine-culture-confirmed infections, mainly from coliform, proteus and pseudomonas species. A total of 20 patients (49%) received antibiotic treatment. The majority of patients received an initial IV dose followed, where required, by oral treatment on discharge. Conclusions: many catheterised patients had complex needs with high rates of urinary infections and admissions for urosepsis. High attendance related less to old age but more to complexity of history, such as neurological conditions and disability. Only a proportion of these patients could be safely treated by district nurse teams. A significant proportion would require more responsive community services with several spells of short-term input (e.g. daily or more than once-daily visits) and access to diagnostics, microbiology, pharmaceutical input and IV treatments.
AHP/ANP is well represented in MCDM 2017, Ottawa
Authors: Karpak Birsen
Published: May 2017

MCDM 2017 is progressing well. There are about 200 papers accepted and among them at least about 15% are AHP/ANP related. There are two invited sessions on AHP/ANP Theory and Applications in Supply Chain Management and Industrial Engineering, each having four papers, in addition to about twenty contributed papers on AHP/ANP.  https://doi.org/10.13022/ijahp2017.v9.is1.479
AN ANP MODEL TO DEVELOP A NATIONAL TRANSFORMATION PLAN
Authors: Bahurmoz Asma Mohammed , Samrgandi Nahla
Published: May 2017

In October 2015, The Saudi Council for Economic and Development Affairs unveiled an austerity plan in response to a drop in the price of oil to around US $26, which threw the country into an unexpected deficit of about $100 billion. Later on, an austerity plan evolved into the National Transformation Plan (NTP) 2020. The NTP focused on the key drivers for economic growth. Although only an outline of the NTP was released at the time, we speculate on what will be the best implementation policy. Knowing that the government is taking a developmental approach that is inclusive, transparent and accountable to all stakeholders in society, we opted to address this question as a multi criteria decision problem formulated in an Analytic Network Process (ANP) model. The ANP is a sound methodology for structuring the problem to find which policy to focus on to make the transformation as effective as possible, taking into account social and political factors in addition to economic ones. The ANP model showed that to make the transformation effective through blending socio-economic and political factors, policy-makers must give priority to management reform over privatization and fiscal reform policies.https://doi.org/10.13022/ijahp2017.v9.is1.483
The façade and the picture plane
Authors: Ferguson Catherine
Published: May 2017

If, following Bois, the task of the painter is the development of a thought that is properly pictorial, then this article will explore the idea of commitment as a problem for discourse: any claim about a painting’s relation to its outsides being a function of what writing is capable of saying in the face of such a thought. Appropriating the biological model of autopoiesis (which sets out to analyse the genesis of a living form from its point of view rather than from the observer’s), the article analyses Uslé’s painting, La Garganta de Albers, Las Muelas de Gaudí, in order to demonstrate that its outsides are a production of its internal ‘organization’. This internal organization cannot be described (from the outside), and so the article suggests the idea that the painting functions through the metaphor of the façade. Ultimately, there is no real evidence for this because the relation between writing and painting is marked by discontinuity. However, although this is a problem for the writer (who might want to control what the painting means), this methodological problem is a sign of commitment insofar as the incomprehensibility encountered in front of the painting elicits a new kind of thinking inaugurated by the work’s specificity.
(Bad) faith in painting(?): Critically re-evaluating the significance of Yu Youhan’s political pop series
Authors: Gladston Paul
Published: May 2017

This article seeks to critically re-evaluate a series of so-called ‘Political Pop’ paintings by the Shanghai-based painter Yu Youhan in relation to existentialist conceptions of good and bad faith as well as recent ethically related reassertions of oppositional criticality within the international art world. It will be argued that any description of Yu’s Political Pop paintings as having been produced definitively in either good or bad faith overlooks a persistent and indeterminate enmeshing of cultural production with locally dominant discourses and practices within the People’s Republic of China (PRC) as well those prevailing internationally that plays deconstructively across the boundary between conscious acceptance and rejection of freedom of choice and, by extension, the supposed limits of oppositional criticality.
Under erasure: Jenny Holzer’s War Paintings
Authors: Bird Jon
Published: May 2017

This article examines Jenny Holzer’s painterly reworkings of redacted American military documents, comparing her practice with some of Nancy Spero’s extended visual narratives of torture and victimization. As two artists immersed in a feminist visual politics (and poetics) of representation where language is both a vehicle and a form of expression, they adopt contrasting strategies of transformation: for Spero via allegory and the mythic, for Holzer through an aesthetic of negation. I read their work partly through Jacques Rancière’s notion of the necessity for bringing traumatic events into visibility, and I argue that in their respective scripto-visual artworks and sensitivity to the materiality of language and its performative dimension, they ‘make the inhuman perceptible’. I also consider their practice as evidence of an ongoing project of foregrounding arts responsibility as witness to history and the historical subject, seeing in their respective modes of figuration and emphasis upon surface (presence/absence, colour, writing) a means of inscribing the body in the text.
Painting is believing
Authors: O’Kane Paul
Published: May 2017

With help from seventeenth-century religious philosopher Blaise Pascal, art history, artists On Kawara and Lee Ufan, this article sets out a contemporary scenario before digging progressively deeper into questions of ‘painting and commitment’. The article attempts to make a case that painting and painters inform or extend our understanding of commitment per se while clarifying our understanding of relationships – casual and otherwise – between art, belief and commitment. The article asserts the idea that the very process of painting begets belief, commitment and faith, and ultimately suggests that painting, by means of its special affinity with images, might be the basis of our particularization and organization of knowledge, as well as being considered ur religion.
Reviews
Authors: Pettitt Daniel , Lloyd Lizzie , Sheleg Moran , Ryan David , Rhodes David , Moonie Stephen , Levy Matthew L. , Benci Jacopo , Whittaker Edward
Published: May 2017

‘Mary Heilmann & David Reed: Two By Two’, Hamburger Bahnhof, Museum für Gegenwart, Berlin, 6 March–11 October 2015

‘Niamh O’Malley: Glasshouse’, Bluecoat, Liverpool, 10 October 2015–10 January 2016

‘Painting 2.0: Expression in the Information Age’, Museum Brandhorst, Munich, 14 November 2015–30 April 2016; Museum Moderner Kunst Stiftung Ludwig Wien, Vienna, 4 June–6 November 2016

Painting 2.0 – Expression in the Information Age, Achim Hochdörfer, David Joselit and Manuela Ammer (eds) (2015) Munich, London and New York: Delmonico/Prestel, 288 pp., ISBN: 9783791354910, h/bk, £45

‘Moira Dryer’, 11R, New York, 7 January–11 February 2016

‘Basil Beattie: When Now Becomes Then: Three Decades’, Middlesbrough Institute of Modern Art, 20 February–10 June 2016

‘Jon Pestoni: Some Years’, Cleveland Museum of Art Transformer Station, Ohio, 23 April–24 July 2016

Go Figure! New Perspectives on Philip Guston, Peter Benson Miller (ed.) (2015) New York: American Academy in Rome/New York Review Books, 156 pp., 51 colour and black & white illustrations, ISBN: 9781590178782, h/bk, £35.00

Formalism and Historicity: Models and Methods in Twentieth Century Art, Benjamin H. D. Buchloh (2015) Cambridge, MA and London: October Books, MIT Press, 529 pp., ISBN: 9780262028523, h/bk, £24
Risk of gestational diabetes mellitus: which lifestyle parameters should be changed?
Authors: Popova Polina Viktorovna , Tkachuk Aleksandra Sergeevna , Bolotko Yana Alexeevna , Gerasimov Andrey Sergeevich , Demidova Ksenia Alexandrovna , Pustozerov Evgenii Anatol'evich , Kuznetsova Liubov Vladimirovna , Grineva Elena Nikolaevna
Published: May 2017

Background. Gestational diabetes mellitus (GDM) is a common complication of pregnancy. It can cause significant problems for the mother and offspring, such as caesarean delivery, birth trauma and the development of type 2 diabetes mellitus (T2DM) in the future. The identification and correction of modifiable risk factors for GDM will provide a possibility to prevent these complications.
Aim. This study aimed to identify the most significant lifestyle parameters affecting the risk of developing GDM.
Methods. The study included 680 pregnant women who underwent oral glucose tolerance test at 2432 weeks of pregnancy and responded to a questionnaire comprising the following sections stratified in a semi-quantitative manner: the consumption of major food groups and drinks and the amount of physical activity and smoking before and during pregnancy. A logistic regression analysis was performed to identify lifestyle parameters that influence GDM development. GDM was diagnosed according to the IADPSG criteria.
Results. GDM was diagnosed in 266 women; the other 414 women formed the control group. The most significant dietary risk factor for developing GDM was the consumption of sausage(s), dried fruits and fresh fruits. Eating sausage(s) more than thrice a week during pregnancy increased the risk of developing GDM by 2.4 times [95% confidence interval (CI), 1.53.8; p 0.001] and so did the consumption of dried fruits more than thrice a week during pregnancy [odds ratio (OR), 6.5; 95% CI, 2.516.8; p 0.001)] compared with the risk of GDM by less consumption of these food groups. A regular consumption of fresh fruits more than 12 times a week during pregnancy reduced the risk of GDM (OR, 0.5; 95% CI, 0.30.8; p = 0.015). The habit of climbing at least four floors per day during pregnancy also reduced the risk of GDM (OR, 0.7; 95% CI, 0.51.0; p = 0.069).
Conclusions. The recommendations for GDM prevention should include limiting the consumption of sausage(s) and dried fruits, increasing the consumption of fresh fruits and introducing regular physical activities, such as climbing stairs.
A class of shape optimization problems for some nonlocal operators
Authors: Fernández Bonder Julián , Ritorto Antonella , Salort Ariel Martin
Published: May 2017

In this work we study a family of shape optimization problem where the state equation is given in terms of a nonlocal operator. Examples of the problems considered are monotone combinations of fractional eigenvalues. Moreover, we also analyze the transition from nonlocal to local state equations.
Genetic traces of never born proteins
Authors: Piwowar Monika , Matczyńska Ewa , Malawski Maciej , Szapieniec Tomasz , Roterman-Konieczna Irena
Published: May 2017

The presented results cover issues related to proteins that were “never born in nature”. The paper is focused on identifying genetic information stretches of protein sequences that were not identified to be existing in nature. The aim of the work was finding traces of “never born proteins” (NBP) everywhere in completely sequenced genomes including regions not expected as carrying the genetic information. The results of analyses relate to the search of the genetic material of species from different levels of the evolutionary tree from yeast through plant organisms up to the human genome. The analysis concerns searching the genome sequences. There are presented statistical details such as sequence frequencies, their length, percent identity and similarity of alignments, as well as E value of sequences found. Computations were performed on gLite-based grid environment. The results of the analyses showed that the NBP genetic record in the genomes of the studied organisms is absent at a significant level in terms of identity of contents and length of the sequences found. Most of the found sequences considered to be similar do not exceed 50% of the length of the NBP output sequences, which confirms that the genetic record of proteins is not accidental in terms of composition of gene sequences but also as regards the place of recording in genomes of living organisms.
Functionalization of polyethetherketone for application in dentistry and orthopedics
Authors: Harting Rico , Barth Marius , Bührke Thomas , Pfefferle Regina Sophia , Petersen Svea
Published: May 2017

Since late 1990s, polyetheretherketone (PEEK) has presented a promising polymeric alternative to metal implant components, particularly in orthopedic and traumatic applications. However, PEEK is biologically inert, which has constrained its potential applications. In this manner, enhancing the bioactivity of PEEK is a huge challenge that must be comprehended to completely understand the potential advantages. Up to now, two noteworthy methodologies are discussed to enhance the bioactivity of PEEK, including bulk and surface modification. Although the latter is extremely challenging due to the very high physical and chemical stability of the high performance polymer, there are some stated modification reactions in the literature, which will be collocated with in the literature-reported PEEK composites in the present article. We will furthermore add information on polymer-based drug delivery systems and the biofunctionalization of polymers in general and discuss their applicability for PEEK, as we estimate that these strategies will gain greater attention in the future. At the end of the article, our own research on the development of a PEEK-associated biodegradable drug-delivery system with potential application in dentistry or orthopedics will be highlighted.
Sample types applied for molecular diagnosis of therapeutic management of advanced non-small cell lung cancer in the precision medicine
Authors: Han Yanxi , Li Jinming
Published: May 2017

In this era of precision medicine, molecular biology is becoming increasingly significant for the diagnosis and therapeutic management of non-small cell lung cancer. The specimen as the primary element of the whole testing flow is particularly important for maintaining the accuracy of gene alteration testing. Presently, the main sample types applied in routine diagnosis are tissue and cytology biopsies. Liquid biopsies are considered as the most promising alternatives when tissue and cytology samples are not available. Each sample type possesses its own strengths and weaknesses, pertaining to the disparity of sampling, preparation and preservation procedures, the heterogeneity of inter- or intratumors, the tumor cellularity (percentage and number of tumor cells) of specimens, etc., and none of them can individually be a “one size to fit all”. Therefore, in this review, we summarized the strengths and weaknesses of different sample types that are widely used in clinical practice, offered solutions to reduce the negative impact of the samples and proposed an optimized strategy for choice of samples during the entire diagnostic course. We hope to provide valuable information to laboratories for choosing optimal clinical specimens to achieve comprehensive functional genomic landscapes and formulate individually tailored treatment plans for NSCLC patients that are in advanced stages.
Coincidence theorem for multi-valued and single-valued systems of transformations
Authors: Gairola U. C. , Jagwan P. S.
Published: May 2017

In this paper we prove a coincidence theorem by generalizing the diverse coincidence theorems and fixed point theorems of Baillon - Singh [
Common fixed point, best approximation and generalized f-weak contraction multivalued mapping in p-normed spaces
Authors: Abbas M. , Rhoades B. E.
Published: May 2017

We establish coincidence point and common fixed point results for multi-valued
A note on the decomposition of Fredholm operators
Authors: Schmoeger Christoph
Published: May 2017

We generalize a result of F. Szigeti concerning the decomposition of Fredholm operators on Banach spaces.
On D-homothetic deformation of trans-Sasakian structure
Authors: Shaikh A. A. , Baishya K. K. , Eyasmin S.
Published: May 2017

The object of the present paper is to study a transformation called
Subharmonics of not uniformly partially coercive Hamiltonian systems
Authors: Timoumi Mohsen
Published: May 2017

In this work, we prove the existence of multiple periodic and subharmonic solutions of the Hamiltonian system
The graphs of fibered automata
Authors: Mućka Anna
Published: May 2017

Fibered automata can be described by their transition diagrams, certain edge-labelled digraphs. We describe digraphs that are unlabelled transition diagrams of fibered automata.
Full-rank non-periodic factorizations of elementary p-groups
Authors: Szabó Sándor
Published: May 2017

It will be shown that for each prime
On an inequality of the Lupaş type
Authors: Barnett N. S. , Dragomir S. S.
Published: May 2017

An inequality of the Lupaş type for Čebyšev functionals is established.
On weighted harmonic Bergman spaces
Authors: Petrosyan A. I.
Published: May 2017

This paper is devoted to the investigation of the weighted Bergman harmonic spaces
A shock problem involving a nonlinear viscoelastic bar associated with a nonlinear boundary condition
Authors: Long Nguyen Thanh , Giai Vo Giang , Truong Le Xuan
Published: May 2017

We study the initial-boundary value problem for a nonlinear wave equation given by
Some properties of a subclass of uniformly convex functions with negative coefficients
Authors: Aouf M. K. , Mostafa A. O.
Published: May 2017

The aim of this paper is to obtain coefficient estimates, distortion theorem, extreme points and radii of close - to - convexity, starlikeness and convexity for functions belonging to the subclass
Generalizations of Hadamard products of certain meromorphic univalent functions with positive coefficients
Authors: Aouf M. K. , Silverman H.
Published: May 2017

The authors establish certain results concerning the generalized Hadamard products of certain meromorphic univalent functions with positive coefficients analagous to the results due to Choi et al. (J. Math. Anal. Appl. 199(1996), 495–501).
Translative covering of a square by a sequence of arbitrary-oriented squares: part II
Authors: Januszewski Janusz
Published: May 2017

Given a collection of squares of arbitrary side lengths whose total area is at least 3. Then the unit square can be covered by translates of these squares.
Quotient structured spaces
Authors: Sasin Wiesław , Lipiński Piotr
Published: May 2017

In this paper we investigate some properties of quotient structured spaces. The notion of a structured space was originally considered by Mostow [

In the beginning we present some basic notions and definitions from structured space theory. Then we discuss some properties of quotient structured spaces. In the third part we present a space-time as a quotient space. At the end of this paper we consider F-quasiregular equivalence relation and the structured space with malicious singularity.
Lifting vector fields and prolongation of connections to higher order fibred frame bundles
Authors: Mikulski Włodzimierz M.
Published: May 2017

We construct some extension
Through a generalized inverse
Authors: Stępniak Czesław
Published: May 2017

Traditionally, the existence of a generalized inverse of a matrix
Approximation of common fixed points of a family of asymptotically quasi-nonexpansive mappings
Authors: Sahu D. R. , Shrivastava S. C. , Malager B. L.
Published: May 2017

In this paper, we study the convergence of the sequence of Ishikawa iteration of rank-
A generalized Ostrowski type inequality for a random variable whose probability density function belongs to L∞[a, b]
Authors: Rafiq Arif , Mir Nazir Ahmad , Zafar Fiza
Published: May 2017

We establish here an inequality of Ostrowski type for a random variable whose probability density function belongs to L
Relations between various continuity concepts in effect algebras
Authors: Khare Mona , Gupta Soni
Published: May 2017

The aim of the present paper is to establish relations between continuity concepts for a nonnegative extended real-valued function
Distortion theorems in the class Kn(D)
Authors: Kir’yatskii Eduard G.
Published: May 2017

This article presents the analysis of properties of functions belonging to the class K

The subclass K̃

The author touches classical and at the same time urgent questions, arising at the study of analytical functions, belonging to some class.
On typically real functions which omit two conjugated values
Authors: Sobczak-Kneć Magdalena
Published: May 2017

In this paper we discuss the class
Generalized three-step iteration schemes and common fixed points of three asymptotically quasi-nonexpansive mappings
Authors: Rashwan R. A. , Abdel Hakim A. A.
Published: May 2017

In this paper, we study strong convergence theorems for a generalized three-step iterative scheme with errors to approximate common fixed points of three asymptotically quasi-nonexpansive mappings in real Banach spaces. Our results generalize and improve upon the corresponding results in [
CR-submanifolds of a nearly trans-hyperbolic Sasakian manifold
Authors: Kumar S. , Dube K. K.
Published: May 2017

In the present paper we have investigated CR-submanifold of a nearly trans-hyperbolic Sasakian manifold. We have also studied parallel distribution relating to
An approach to Hamiltonian mechanics on glued symplectic pseudomanifolds
Authors: Batubenge A. , Sasin W.
Published: May 2017

We define a class of Frölicher spaces locally diffeomorphic to Frölicher subspaces of the Euclidean space ℝ
On almost normality
Authors: Kalantan Lutfi N. , Allahabi Fateh
Published: May 2017

A topological space
On naturality of the Legendre operator
Authors: Mikulski Włodzimierz M.
Published: May 2017

We deduce that all natural operators of the type of the Legendre operator from the variational calculus in fibred manifolds are the constant multiples of the Legendre operator.
On left multipliers and the commutativity of prime rings
Authors: Ashraf Mohammad , Ali Shakir
Published: May 2017

Let
On a subclass of uniformly convex functions with fixed second coefficient
Authors: Darwish H. E.
Published: May 2017

Using of Salagean operator, we define a new subclass of uniformly convex functions with negative coefficients and with fixed second coefficient. The main objective of this paper is to obtain coefficient estimates, distortion bounds, closure theorems and extreme points for functions belonging of this new class. The results are generalized to families with fixed finitely many coefficients.
Certain sufficiency conditions on Fox–Wright functions
Authors: Chaurasia V. B. L. , Parihar Hari Singh
Published: May 2017

The main object of this paper is to find certain conditions for the function
Sameness between based universal algebras
Authors: Ricci Gabriele
Published: May 2017

This is the continuation of the paper “Transformations between Menger systems”. To define when two universal algebras with bases “are the same”, here we propose a universal notion of transformation that comes from a triple characterization concerning three representation facets: the determinations of the

Hence, this notion consists of three equivalent definitions. It characterizes another technical variant and also the universal version of the very semi-linear transformations

Universal transformations allow us to check the

Contrary to present beliefs, even the foundation of abstract Linear Algebra turns out to be incomplete.
Division point in the Poincaré upper half plane
Authors: Sönmez Nilgün
Published: May 2017

In this work, it is shown that the coordinates of the division point can be determined by the formula in the Poincaré upper half plane.
Cluster sets and related properties of multifunctions
Authors: Przemski Marian
Published: May 2017

In this paper we present some types of cluster sets of multifunction. Using these concepts we relate properties of cluster sets to some generalized continuity properties, minimality of multifunctions and closedness of its graphs.
Riemannian vector bundles have no canonical linear connections
Authors: Mikulski W. M.
Published: May 2017

We prove that Riemannian vector bundles have no canonical linear connections.
Maximal classes for the family of quasi-continuous functions with closed graph
Authors: Sieg Waldemar
Published: May 2017

In this paper we consider classes of functions
Existence of positive solutions to BVPs of higher order delay differential equations
Authors: Shen Jianhua , Dong Jing
Published: May 2017

The paper is concerned with the existence of positive solutions for the nonlinear eigenvalue problem with singularity and the superlinear semipositone problem of higher order delay differential equations. The main results are obtained by using Guo-Krasnoselskii’s fixed point theorem in cones. These results extend some of the existing literature.
On a sum form functional equation related to entropies and some moments of a discrete random variable
Authors: Nath P. , Singh D. K.
Published: May 2017

The general solutions of a sum form functional equation have been obtained. The importance of its solutions in relation to the entropies and some moments of a discrete random variable has been discussed.