bluuebunny/crossref_metadata_2025 huggingface dataset:
Combination of alpha-lipoic acid and mitoquinone improves myocardial function in an experimental model of myocardial infarction in aged rats
Authors: Nemati Samira , Badalzadeh Reza , Zavvari-Oskuye Zohreh , Mokhtari Behnaz , Bafadam Soleyman , Vakili Abedin
Published: July 2023

This study aimed to investigate whether a combination of two potent antioxidants, alpha-lipoic acid (ALA) and mitoquinone (Mito Q), could improve myocardial function and the underlying mechanisms in an experimental model of myocardial infarction in aged rats. To develop a myocardial infarction model in aged rats the left anterior descending artery (LADA) was transiently occluded for 30 minutes and then re-perfused for 24 hours. Mito Q (10 mg/kg, IP) and ALA (100 mg/kg, gavage) was given daily for 2 weeks before occlusion of LADA. Subsequently, 24 hours after ischemia, left ventricular function was measured, and inflammatory factors (IL-6, IL-1β, TNF-α), tissue apoptosis, expression of Bax, Bcl-2, cytochrome C (Cyt-c), and caspase-3 were evaluated using ELISA, TUNEL, real-time PCR methods, respectively. The findings of this study indicated that the administration of the combination of ALA and Mito Q significantly improved cardiac function. This improvement was linked to a reduction in the expression of pro-inflammatory cytokines TNF-α, IL-6, and IL-1β (P < 0.001) and apoptotic markers (Bax, caspase-3, and Cyt-c), as well as a decrease in the percentage of TUNEL-positive cells (P < 0.001). The combined administration of ALA and Mito Q was found to synergistically reduce cardiac dysfunction in aged rats with myocardial infarction by inhibiting both the inflammatory and apoptotic pathways. This compound may offer a promising solution for elderly individuals who are at risk of heart attack, however, further research is needed to validate its potential
Dietary Supplementation of Organic Zn Improves Digestive Enzyme Activities, Antioxidant Response, and Growth Performance of Nile Tilapia Oreochromis sp
Authors: Inarto Hendri , Ekasari Julie , Jusadi Dedi , Nasrullah Hasan , Suprayudi Muhammad Agus
Published: July 2023

This research aimed to evaluate the effects of dietary organic zinc (Zn) supplementation at different levels on various physiological parameters in Nile tilapia (Oreochromis sp.). Triplicate groups of nile tilapia (8.3 ± 0.02 g) were fed diets supplemented with different levels of organic Zn (0, 20, 40, 80 and 160 mg kg-1) for 60 days. The study focused on assessing digestive enzyme activities (lipase, amylase, chymotrypsin, and trypsin), intestinal morphometry (villus width, villus height, and absorption surface area), antioxidant response (superoxide dismutase and malondialdehyde), health status (lysozyme activity and respiratory burst), growth performance, and organ zinc content. The results revealed significant outcomes. Digestive enzyme activities increased up to 40 mg kg-1 of dietary Zn, but declined at higher levels. Fish fed Zn-supplemented diets at 20-80 mg kg-1 exhibited enhanced absorption surface area, while the control group (0 mg kg-1) and the highest dose (160 mg kg-1) showed reduced absorption surface area. After an air exposure challenge, the antioxidant response showed significantly higher superoxide dismutase (SOD) activity at Zn levels of 20 and 40 mg kg-1, with the lowest malondialdehyde (MDA) levels observed at 40 mg kg-1. Furthermore, fish fed diets with 40 mg kg-1 Zn demonstrated significantly higher lysozyme activity, while respiratory burst was elevated in tilapia receiving Zn doses of 20 and 40 mg kg-1. Growth performance parameters improved significantly up to 40 mg kg-1 of dietary Zn, beyond which they declined. The Zn requirement was estimated to be 38.4 mg kg-1 based on the specific growth rate using broken-line regression analysis. Tilapia fed diets containing Zn levels ranging from 20 to 80 mg kg-1 showed notable improvements in protein retention, final biomass, and feed intake. The survival rate remained unaffected by the experimental diets. Zinc content in the liver, muscle, and intestine did not exhibit significant changes with varying dietary Zn levels. These findings provide valuable insights into the effects of dietary organic Zn supplementation on Nile tilapia, contributing to the development of optimized nutritional strategies for enhancing growth performance and overall health in aquaculture production systems.
The Fractional Non-Polynomial Spline Method: Precision and Modeling Improvements
Authors: Yousif Majeed A. , Hamasalh Faraidun
Published: July 2023

The authors have requested that this preprint be removed from Research Square.
Starch/Pectin as Emerging Renewable Materials for Fabrication of Sustainable Bioplastics for Food Packaging Applications
Authors: Arooj Aqsa , Khan Musammir
Published: July 2023

Currently, due to serious environmental concerns of using non-biodegradable fossil fuel based plastics for food packaging application, the renewable bioplastic obtained from second generation biobased materials (biopolymers & plasticizers) could be an attractive alternative, but fulfilling the consumers demand is a challenging task. Here in this work, starch/pectin as matrix and chitosan co-biopolymers together with tartaric acid (TA)/citric acid (CA) as natural plasticizers were used to fabricate their bioplastics by condensation polymerization accompanied by intermolecular hydrogen bonding interactions. The FTIR analysis confirmed the successful formation of amide/ester bonds and non-covalent hydrogen bonding interactions, while the broad XRD bands indicated the amorphous nature of all the obtained bioplastics. Their swelling ratio ranged between (510–620 ± 50%) and the mass loss (44–76 ± 5%), which was susceptible to acid facilitated hydrolysis for 24 h incubation in water. The obtained tensile modulus was in the range (0.5 ± 0.1 to 7.5 ± 0.5 MPa), which was highest for starch/TA film (7.5 ± 0.5 MPa), attributed to the more plasticization effect in the CA based films. All the samples showed complete degradation (97 ± 2.5%), after 3 days dipping in soil and were ecofriendly by ecotoxicity assay. Therefore, these pure biobased bioplastics could be useful materials for the future food packing industry.
Bone Marrow Tumor Microenvironment of Obese Hodgkin Lymphoma Patients: implications of insulin axis
Authors: Matos Andreia , Marinho-Dias Joana , Ramalheira Sofia , Roncon Susana , Pereira Dulcineia , Rodrigues Carla , Mariz Mário , Miranda Ana , Brízido Helena , Bicho Manuel , Hu Pingzhao , Pereira Flávia , Cruz Tânia , Cawthorn William , Ramsay Alan G , Oliveira Maria J. , Ribeiro Ricardo
Published: July 2023

Background
Excessive adiposity, or obesity, has been associated with cancer promotion, including an increased risk for developing Hodgkin Lymphoma (HL). However, the association between obesity and survival in HL can be somewhat paradoxical and may indeed influence prognosis. Examining the bone marrow (BM) cytokine profile in HL patients could provide insights into the mechanisms underlying the altered association between excess adiposity and HL. The BM is an important site for hematopoiesis and can be influenced by various factors, including disease processes and systemic metabolic changes associated with obesity.
Methods
From our cohort, we analyzed interstitial marrow fluid (IMF) from BM aspirates of 16 HL patients at diagnosis and 11 control subjects. Participants were then matched by sex, age, and Body mass index (BMI) for inclusion in our discovery protein array analysis (n = 8 HL and n = 8 donors). We validated our findings in the total sample by measuring adipokine-related molecules using ELISA. Adiposity was measured through abdominal circumference measurement and BMI. Gene expression analysis was conducted through RT-qPCR. Activated signaling pathways were analyzed using HL cell line (L428 cells). Statistical analyses were performed using SPSS and GraphPad.
Results
The IMF of HL patients presented downregulation of interleukins (IL-1α/β, IL-6sR, IL-12), chemokines (CCL2, CCL3, CCL16), IGF-axis mediators (IGFBP-1, IGFBP-2, IGFBP-3, IGF-1sR), sTNFRII, TGFβ1, leptin, osteoprotegerin (OPG), and Fas compared to healthy donors and after controlling for adiposity status. Interestingly, HL overweight/obese subjects showed up-regulation of OPG and lymphotactin in IMF. The results were confirmed by quantification of cytokines, where we observed lower levels of insulin growth factor binding protein IGFBP-3 and higher levels of OPG levels in HL patients. The high-molecular weight (HMW) and total of adiponectin levels were high in HL BM. We further demonstrate that LEPR, TGFβ1, and IGFBP3 transcripts were upregulated in fractionated BMAd from HL compared to controls, while IFG2R was upregulated in SC. Finally, we observed a possible modulation of L428 cells through IGFBP-3 in an IGF-1-dependent manner, which could be reflected in the BM TME of HL disease.
Conclusions
Our data supports a role for the insulin axis in the BM microenvironment of obese HL patients, particularly through the regulation of insulin ligand-binding proteins.
Ultimate boundedness of the solution for a stochastic delayed Lotka-Volterra food chain chemostat model
Authors: Liu Chenyu , Zhang Xiaofeng
Published: July 2023

For the solutions of stochastic systems, stochastic ultimate boundedness has always been a very important property. Thus, in this paper, we will investigate a stochas-tic delayed Lotka-Volterra food chain chemostat model. Firstly, we prove the existence and uniqueness of global positive solution for this model. Then we future prove the positive solution is ultimately bounded by constructing Lyapunov functional and utilizing Chebyshev inequality.
Security Performance Analysis during Side-Channel Attack Using Novel Cryptography Algorithm for VM Cloud
Authors: S Gnanavel , Sathianesan Godfrey Winster , K.E Narayana , E Baburaj , N Arunachalam , K Valarmathi
Published: July 2023

Cloud computing is a relatively new technology that allows multiple users to share computational resources and data over the internet. It supports multi-tenant to meet the needs of users to access the resources at the same time, it improves the profitability of the cloud service provider. The Virtual Machine (VM) operates on the same core device that is the focus of any aberrant or malicious attack. These attacks may include data leakage, privacy breaches, and unauthorized access to cloud resources. The outsider attacks may be server spoofing, stolen verifier, password guessing, impersonation, and replay attacks at the cloud’s network layer. The insider attacks may be side-channel attacks to gain access to shared resources. A Self-Adaptive Honey Encryption (SAHE) method for stronger multi-level authentication in a cloud environment the hypervisor layer monitors the running cloud memory, CUP, communication port, and network infrastructure. Introduce the classifier mode to identify the attack and VM risk level (high, medium, and low) to improve the VM performance and attack identification. A rule-based mechanism to detect a side-channel attack by monitoring cache data access. Processes running on the VM can use the cache of another virtual machine, creating a cache conflict in the system. The cache-based attack on the Physical Machine (PM) creates the cache contention to mitigate the attacker’s data. We propose a novel rule-based authentication with the swam optimization method for shifting the resource from an optimized VM into a physical machine. The migration method for optimal PM makes the VM free from cache contention, and it also mitigates the cache side-channel attack in the cloud environment.
Nano Porous Anodic Aluminum Oxide: An Overview on its Fabrication and Potential Applications
Authors: Kumar Sur Ujjal
Published: July 2023

The quick development in nanotechnology has raised the status of this
modern technology owing to the decrease in the sizes of structures and devices. There
has been considerable dispute concerning the future consequences of nanotechnology.
Nanotechnology has the probable ability to design many new and novel materials and
devices in smaller dimensions with broad-range applications in medicine, electronics
and sustainable energy production. Nano porous anodic aluminum oxide (AAO) films
consisting of self-organized hexagonal arrays of invariable parallel nanochannels have
been widely applied as the building block to fabricate various functional nanostructures
of different morphologies such as nanoparticles, nanowires and nanotubes. These
functional nanostructures can be potentially utilized in various applications like
magnetic storage media, optoelectronics, bio/chemical sensors, photonics and
plasmonics. This chapter describes the different fabrication processes of AAO films in
detail along with citation of a few interesting applications.
Preparation of Nanocellulose From Plants
Authors: Fu Li
Published: July 2023

Plants contain the most abundant natural polymer cellulose in nature. Plants
have a multilayered structure, made up of cells at the microscopic level. The main
material of cells exists in the cell wall, mainly in the form of cellulose nanofilament-matrix composite structure, which plays a crucial role in the performance and function
of plants. Nanocellulose, as a kind of environmentally friendly renewable polymer
material, has great application potential and ecological benefits. In this chapter, the
structural properties and preparation methods of nanocellulose are introduced, and the
characterization methods and modification methods of nanocellulose are summarized.
Finally, the design and construction of new nanocellulose materials in the future are
prospected.
Plant Polyphenol Nanoparticle's Preparation and Application
Authors: Fu Li
Published: July 2023

Plant polyphenols are important secondary metabolites in plants. They have
strong antioxidant activity, which has a certain effect on the prevention of
cardiovascular diseases and other chronic diseases, and can be widely used as
antioxidants in food, drugs, and many other fields. The use of nanotechnology to make
polyphenolic compounds into nanoparticles can effectively protect polyphenols from
destruction, and improve the antioxidant and stability of polyphenols. In this chapter,
the preparation technology and functional characteristics of polyphenol nanoparticles
are discussed in detail, and the preparation and application of polyphenol nanoparticles
are provided with references. 
Lipids, Oxidation, and Cardiovascular Disease
Authors: Day-Walsh Priscilla
Published: July 2023

Cardiovascular disease (CVD) remains one of the leading causes of
morbidity and mortality worldwide with altered lipid metabolism as an important risk
factor. In the current chapter we discuss processes involved in lipid metabolism, the
past and emerging roles of various lipoprotein cholesterol molecules in this process,
free fatty-acid metabolism and the various mechanisms of lipid oxidation and their
impact on vascular physiology in health and disease. We further describe the role of
reverse cholesterol transport (RCT) in the elimination of lipids as bile acids, and finally
discuss current clinical interventions based on emerging technologies against
dyslipidemia, hypertriglyceridemia, and CVD
The Emerging Role of Microbiome in Cardiovascular Diseases
Authors: Shehata Emad , Day-Walsh Priscilla
Published: July 2023

Cardiovascular disease (CVD) has become one of the leading causes of poor
lifelong health and well-being. Meanwhile, the microbiome has emerged as one of the
key determinants of human cardiometabolic homeostasis and the risk of CVD. While
the clustering of the microbiome into phylum ratios or enterotypes has been correlated
to specific disease phenotypes and population characteristics, the composition of a
typical ‘healthy human microbiome’ is yet to be defined. Several population-based
studies have shown an association between certain microbial species with CVD,
although the inconsistencies have made the interpretation of such associations very
difficult as it is not possible to pinpoint microbial populations associated with CVD.
However, here we discuss current evidence on the role of the microbiome and its
metabolites on the risk of CVD. We further explore current clinical studies
investigating prebiotics and probiotics as potential therapeutic targets to modulate the
microbiome for the benefit of the host to prevent cardiometabolic diseases. We
highlight that further work to understand the role of specific species/sub-species,
strains and polymorphisms within those strains, as well as microbial gene expression
profiles and their respective metabolites is required. Coupled with high-resolution
metagenomics and metabolomics as well as a unified approach in characterising
common gut microbial communities based on global population observations, this
would provide better indicators of disease phenotype and a better framework for a
divergence to dysbiosis. The challenges that will need to be overcome in order to
define a healthy microbiome and advance the clinical use of prebiotics and probiotics
as well as faecal microbiota transplantation will also be discussed.
Improvement of Nitric Oxide Availability in Myocardial Ischemia/reperfusion: Role of Nanotechnology as a Therapeutic Approach
Authors: J Kogan Marcelo , Salazar-Cornejo Francisco , Gajardo Abraham , Rodrigo Ramón
Published: July 2023

In the search for an effective treatment against myocardial damage caused
by oxidative stress, it has become necessary to generate new therapies that overcome
the difficulties and failures observed in conventional therapies. Therefore,
nanotechnology and nanoparticle development may open new horizons for the control
and therapy of oxidative stress and associated myocardial damage. The term
nanomaterials describe materials with nanoscale dimensions (< 100 nm). In this
chapter, different nanoparticle drug delivery systems, along with their targeting
strategies, and how they can help to improve therapeutic failure in oxidative stress
using nanoparticles in the control of myocardial infarction and oxidative stress will be
discussed. Achieving an inhibition of oxidative stress producers or improving the
endogenous antioxidant capacity through drug delivery by nanoparticles increases the
drug’s aqueous solubility, protects its degradation, allows prolonged release, and
improves the bioavailability, determining a targeted delivery, and decreases the toxic
side effects. It leads to new therapeutic opportunities for both monotherapies and
combined therapies, benefiting from nanoparticles' particularities associated with
increased solubility, bioavailability, and specificity.
Colorimeter design for dry food-products inspection using TCS3200 sensor and Arduino Mega-2560
Authors: Prabowo Sulistyo , Utama Sutrisno Chandra Kadwa , Purnawan Candra Krishna , Rahmadi Anton , Yuliani Yuliani
Published: July 2023

This report describes the successful construction of a Colorimeter CK20.1 prototype using a TCS3200 sensor based on the Arduino Mega-2560 microcontroller for solid foodstuffs inspection. The sample color exposed is presented in RGB form. In this experiment, a commercial colorimeter (ColorFlex EZ Spectrophotometer, with the output, is in L*a*b* form) was applied as a validator of the prototype quality performance on color reading for green beans, wheat flour, palm sugar, ground coffee, and cocoa powder. Data were analyzed for mean comparison using t-test or Mann-Whitney for normally or not normally distributed data, respectively. Before data analysis, the RGB data provided by the prototype was transformed to L*a*b* by the template available from colormine.org and vice versa for the data provided by the ColorFlex EZ. The results showed that color component measurement data from the Colorimeter CK20.1 prototype and the Color FlexEZ were significantly different (p<0.05) for all the foodstuffs observed; however, the color produced by each color component is likely very similar visually. Further development of the CK2.1 prototype is being done to provide a cheap and practical color detector.
The Combined Effect of Infant and Mother Secretor Status on Infant Susceptibility to Viral Gastroenteritis and Celiac Disease
Authors: Das Indrani , Murphy Robyn , Goldman Aaron
Published: July 2023

Celiac disease is a prevalent autoimmune disorder with a rising incidence of 7.5% annually during the second half of the 20th century and the 21st century. Not all genetically susceptible individuals that carry the risk alleles HLA DQ2 and DQ8 go on to develop celiac disease, suggesting that there may be other environmental triggers that contribute to the development of celiac disease in genetically susceptible individuals. Gastroenteritis during infancy has been shown to be associated with increased risk of celiac disease. Secretor status, per the FUT2 genotype, and subsequent alterations in the microbiota, is associated with risk of gastroenteritis in infants. This review investigates the literature from January 2010 to June 2022 to determine the combined effect of secretor status and viral gastroenteritis on the development of celiac disease. Mothers with the secretor phenotype and infants with the non-secretor phenotype provided the most protection against particular strains of gastroenteritis and celiac disease. Both the maternal and infant secretor status, as well as the infant’s Lewis status and ABO blood group can influence the infant’s susceptibility to different viral strains, which cause gastroenteritis. Gastroenteritis caused by viral infections can damage intestinal epithelial cells, cause dysbiosis, and affect pro-inflammatory cytokines, which exacerbate celiac disease onset. Understanding the effect of secretor status and gastroenteritis on celiac disease may provide a novel approach to early screening and preventative strategies to reduce risk factors that contribute to the onset of celiac disease.
COMPARATIVE STUDY OF CISATRACURIUM AND ATRACURIUM IN DIFFERENT DOSES FOR INTUBATION DURING GENERAL ANESTHESIA IN LOWER ABDOMINAL SURGERY: A PROSPECTIVE RANDOMIZED DOUBLE-BLIND INTERVENTIONAL TRIAL
Authors: GURJAR VEERENDRA SINGH , LALL TARUN , MEENA SURENDRA
Published: July 2023

Objective: General anesthesia requires smooth endotracheal intubation, aided by neuromuscular blocking agents. Atracurium and cis-atracurium are non-depolarizing agents used for muscle relaxation. Succinylcholine, though effective, has undesirable side effects. This study aims to compare atracurium and different doses of cis-atracurium to assess their onset, duration, recovery, hemodynamic effects, and side effects, in order to identify the ideal agent for intubation.

Methods: The study will compare atracurium (0.5 mg/kg) with two different doses of cis-atracurium, namely 0.10 mg/kg and 0.15 mg/kg. The parameters evaluated will include the onset of neuromuscular blockade, duration of blockade, recovery time, hemodynamic effects, and incidence of side effects. Neuromuscular monitoring will be employed to ensure proper dosing and prevent residual paralysis.

Results: The study will provide valuable data on the comparative characteristics of atracurium and cis-atracurium at different doses. This includes their onset of action, duration of neuromuscular blockade, recovery time, impact on hemodynamic parameters, and occurrence of side effects. The results will shed light on the efficacy, safety, and tolerability of these drugs for endotracheal intubation.

Conclusion: The study aims to identify the most suitable neuromuscular blocking agent for facilitating endotracheal intubation by comparing atracurium and different doses of cis-atracurium. By assessing their onset, duration, recovery time, hemodynamic effects, and side effect profiles, clinicians can make informed decisions to optimize patient care during general anesthesia.
Modeling the effects of climate change on the population dynamics of mosquitoes that are vectors of infectious diseases
Authors: Díaz-Marín Homero G. , Osuna Osvaldo , Villavicencio-Pulido Geiser
Published: July 2023

We incorporate almost periodic functions in a mosquito model to take into account a loss of synchronicity in the population dynamics of mosquitoes due to climate change. The model takes into account the skip oviposition strategy that is associated with the mosquitoes that are vectors of infectious diseases as dengue, malaria and leishmaniasis. We prove existence and uniqueness of a stable almost periodic solution for some conditions over the parameters of the model. Numerical simulations are performed using values estimated for the life cycle of Aedes albopictus gathered in literature. The results show that the vector population can be underestimated or overestimated if an almost periodic dynamics is approximated by a periodic dynamics. Therefore, using an almost seasonal model can be more adequate to design breeding habitat-targeted mosquito control strategies when seasonal drivers are modeled since climate-mediated shifts can induce a loss of periodicity in environmental drivers.
Energy Efficient in Cloud Computing
Authors: Siddalingamma Smt.
Published: July 2023

Abstract: Today, both parallel and distributing computing have became ubiquitous in the forms of clouds and cyber physical systems, The size of cloud data center is growing rapidly. The larger the data center is, the more energy it consumes. Therefore, more and more researchers focus on energy efficient resource management techniques in the data center. In which manage the load factor and cpu utilization. we consider about cloud computing, its working, its problem definition, virtual machine requirements( executing VMs with similar execution time), objectives and future development of cloud computing. This has led to immense usage of energy, power consumption, usage of e-equipment’s and so on. To overcome this, efforts and techniques are reinforced to save energy, power consumption and the usage of equipment’s to save the planet. Energy efficiency is increasingly important for future ICT. To reduce the power consumption of cloud data centers we aim to reduce the efficient usage of power consumed by IT equipments. EEICC attainable by using eco-friendly computing resources.
ANALISIS KUAT TEKAN DAN ULTRASONIC PULSE VELOCITY (UPV TEST) PADA MUTU BETON K 350 MENGGUNAKAN BETON SISA PENGUJIAN SEBAGAI SUBSTITUSI AGREGAT KASAR
Authors: Azhar Darujati  , Sartika Nisumanti  , Ghina Amalia
Published: July 2023

Salah satu upaya untuk mengurangi eksploitasi batuan alam sebagai bahan penyusun beton adalah memanfaatkan beton sisa pengujian. Beton sisa pengujian yang digunakan adalah beton sisa atau limbah dari hasil pengujian laboratorium sebagai pengganti agregat kasar dalam pembuatan beton baru. Tujuan penelitian ini adalah untuk mengetahui pengaruh dari penggunaan beton sisa pengujian sebagai substitusi agregat kasar dalam campuran beton terhadap nilai kuat tekan dan kepadatan melalui uji ultrasonic pulse velocity (UPV). Metode penelitian yang digunakan pada penelitian ini adalah metode eksperimental dengan melakukan pengujian kuat tekan beton dan pengujian ultrasonic pulse velocity (UPV test). Dari hasil pengujian kuat tekan rata-rata beton campuran sisa pengujian mengalami peningkatan kuat tekan beton pada variasi 25% sebesar 25.3 MPa, 35% sebesar 26.7 MPa, dan 50% sebesar 28.6 MPa, akan tetapi tidak melebihi beton normal sebesar 30.6 MPa. Sedangkan hasil pengujian ultrasonic pulse velocity (UPV) mengalami peningkatan pada rata-rata cepat rambat gelombang variasi 25% sebesar 4034.0 m/s, 35% sebesar 4413.7 MPa, 50% sebesar 4589.3 m/s, serta beton normal nya sebesar 4534.3 m/s. Jadi semakin tinggi nilai kuat tekan beton maka akan semakin tinggi juga hasil pengujian UPV.
IDENTIFIKASI FAKTOR-FAKTOR RISIKO PADA PROYEK INFRASTRUKTUR DASAR DAN FASILITAS UMUM PENUNJANG PARIWISATA DI PELABUHAN BENOA, BALI
Authors: I Komang Agus Ariana  , I Gusti Ngurah Putu Dharmayasa  , I Nengah Riana  , Nyoman Bayu Kurniawan Bendesa
Published: July 2023

Secara umum risiko pada proyek konstruksi dapat mempengaruhi tujuan proyek yaitu mempengaruhi biaya, mutu dan waktu. Dalam proyek konstruksi, faktor risiko merupakan kemungkinan yang menyebabkan terjadinya kerugian. Studi ini dilakukan untuk mengetahui faktor-faktor risiko yang dominan dan mitigasi risiko yang menyebabkan keterlambatan pelaksanaan pada proyek infrastruktur dasar dan fasilitas umum penunjang pariwisata di Pelabuhan Benoa. Dalam penelitian ini, data dikumpulkan melalui kuisioner yang selanjutnya di cek validitas dan realibilitasnya menggunakan SPSS. Selanjutnya untuk menentukan risiko dominan digunakan metode severity index. Berdasarkan penelitian ini terdapat 20 faktor risiko yang menyebabkan keterlambatan proyek, Risiko yang dominan berdasarkan tingkat risiko adalah kejadian tak terduga (peristiwa bencana alam, kebakaran) sebesar 12%, perubahan pada pekerjaan yang sudah selesai sebesar 10%, perubahan lingkungan termasuk perubahan cuaca atau iklim di lokasi proyek sebesar 10%, perbaikan yang tidak sesuai dengan spesifikasi sebesar 8%, dan keterbatasan wewenang personil/pemilik dalam pengambilan keputusan sebesar 8%. Risiko-risiko dominan yang teridentifikasi pada proyek sangat perlu dicarikan solusi karena dampaknya yang sangat signifikan terhadap kinerja proyek.
Pelayanan Publik Berbasis Sistem Informasi Penatih (SIPENA) di Kelurahan Penatih Kecamatan Denpasar Timur
Authors: Munikavila Ni Putu Aris , Larantika Anak Agung Ayu Dewi
Published: July 2023

Pelayanan publik di Desa Penatih dilakukan dengan Sistem Informasi Penatih (SIPENA) berbasis web. Implementasi program SIPENA yang dilakukan oleh Desa Penatih dilakukan untuk dapat memberikan pelayanan publik yang cepat, tepat dan akurat. Tujuan dari penelitian ini adalah untuk mengetahui dan memahami pelayanan publik berbasis SIPENA dan faktor apa saja yang menjadi kendala dalam pelayanan publik berbasis SIPENA di Desa Penatih. Pendekatan yang digunakan dalam penelitian ini adalah menggunakan metode deskriptif kualitatif dengan penerapan teori Edward III. Pengumpulan data dilakukan dengan teknik observasi, wawancara, dan dokumentasi. Pemilihan informan dilakukan dengan teknik purposive sampling, dan analisis data kualitatif bersifat induktif. Hasil penelitian menunjukkan bahwa implementasi program SIPENA dalam penyelenggaraan pelayanan publik di Desa Penatih sudah berjalan cukup efektif, Namun masih terdapat beberapa faktor yang menjadi kendala dalam pelaksanaan program SIPENA di Desa Penatih terkait dengan isi kebijakan, dukungan sumber daya manusia, sarana dan prasarana serta komunikasi.
Penerapan Asas Keterbukaan Pada Pemerintah Desa Dasan Tapen Kecamatan Gerung Kabupaten Lombok Barat
Authors: Misriani Dita , Rispawati R. , Alqadri Bagdawansyah , Yuliatin Y.
Published: July 2023

Penelitian bertujuan untuk mendeskripsikan peran pemerintah desa dalam penerapan asas keterbukaan pada pemerintah desa, faktor-faktor yang mempengaruhi pelaksanaan asas keterbukaan, dan upaya pemerintah desa dalam menerapkan asas keterbukaan dan transparansi di Desa Dasan Tapen Kec.Gerung Kab. Lombok Barat. Penelitian ini menggunakan pendekatan kualitatif dengan jenis deskriptif. Maka subyek dalam penelitian ini, adalah kepala desa, sekretaris desa perangkat desa bagian keuangan dan 2 informan dari tokoh agama dan tokoh masyarakat. Data yang telah terkumpul dianalisis melalui reduksi data, penyajian data, dan penarikan kesimpulan. Data yang telah dianalisis diuji kembali melalui triangulasi sumber dan waktu. Hasil dari penelitian ini menunjukkan bahwa strategi pemerintah desa dalam pelaksanaan asas keterbukaan pada Pemerintah Desa Dasan Tapen Kec. Gerung Kab. Lombok Barat meliputi persiapan informasi, mengolah informasi dan pelayanan perangkat desa. Faktor-faktor yang mempengaruhi penerapan asas keterbukaan pada pemerintah desa meliputi faktor internal seperti fasilitas, dan sumber daya manusia, dan faktor eksternal seperti kerja sama, ide atau gagasan masyarakat,dan kepemimpinan kepala desa.Pelaksanaan penerapan asas keterbukaan pada pemerintah desa adalah dengan menjalankan Undang-Undang Nomor 6 Tahun 2014 tentang desa.
Analisis Kinerja Keuangan Daerah di Kabupaten Tabanan
Authors: Wibawa Agus , Antarini Lilik , Marsitadewi Komang Ema
Published: July 2023

Kinerja keuangan daerah adalah tingkat pencapaian dari suatu hasil kerja di bidang keuangan daerah yang meliputi peneriman dan belanja daerah dengan menggunakan sistem keuangan yang ditentukan melalui suatu kebijakan atau ketentuan perundang-undangan selama satu periode anggaran. Pengelolaan sistem keuangan daerah yang baik harus sesuai dengan ketentuan perundangan yang berlaku, pengelolaan harus dilakukan dengan prinsip transparansi, akuntabel, efektif dan efesien serta berorientasi sasaran dan kemanfaatan. Penelitian ini melakukan pengkajiaan/telaah tingkat pengungkapan wajib Laporan Keuangan Pemerintah Daerah (LKPD) tahun 2018 sampai tahun 2020 untuk mengidentifikasi kecukupan pengungkapan LKPD tersebut. Penelitian ini bertujuan menganalisis permasalahan yang berkaitan dengan kriteria pemenuhan opini Wajar Tanpa Pengecualian (WTP) oleh pemeriksa/auditor. Temuan Hasil Penelitian menunjukkan bahwa kondisi riil LKPD masih banyak harus diperbaiki, semestinya dalam pemberian opini oleh BPK RI Perwakilan Provinsi Bali maksimal pada kriteria Wajar Dengan Pengecualian (WDP), sehingga sangat kurang relevan diberikan opini WTP. Hasil pengukuran indeks pengelolaan keuangan daerah diharapkan dapat memacu dan memotivasi pemerintah daerah dalam meningkatkan kinerja pengelolaan keuangan daerah, termasuk kepada Pemerintah Kabupaten Tabanan.
Inovasi Eco-Enzyme dalam Mendukung Pemerintah Menuju Net Zero Emission di Indonesia
Authors: Yulistiar Fadhil Wahyu , Manggalou Singgih
Published: July 2023

Dalam mendukung upaya pemerintah Indonesia untuk mencapai target Net Zero Emission, salah satu solusi yang dapat diandalkan adalah dengan menerapkan inovasi Eco-Enzyme. Eco-Enzyme merupakan solusi alternatif yang ramah lingkungan dalam mengolah sampah, terutama di tingkat masyarakat sebagai lini terkecil. Dengan menggunakan Eco-Enzyme, sampah organik dapat dipecah menjadi unsur yang lebih sederhana sehingga dapat diolah dengan lebih efektif dan efisien. Selain itu, penggunaan Eco-Enzyme juga dapat membantu mengurangi emisi gas rumah kaca yang dihasilkan dari pembakaran sampah. Dari sini, dapat disimpulkan bahwa penerapan inovasi Eco-Enzyme dalam pengelolaan sampah memiliki dampak positif bagi lingkungan dan mendukung upaya pemerintah dalam mencapai target Net Zero Emission di Indonesia.
Penerapan Tema Rancangan Modern Tropis pada Fasilitas Pusat Fotografi Digital di Denpasar
Authors: Agung Lanang Pradnyana  , I Wayan Wirya Sastrawan  , Agus Kurniawan
Published: July 2023

Fotografi menjadi salah satu pekerjaan professional yang bisa dicapai melalui pelatihan maupun uji kompetensi fotografi dan bisa menjadi lahan komersil bagi setiap orang terutama di kota besar seperti Denpasar. Perkembangan minat masyarakat Bali khususnya Denpasar dalam bidang fotografi dapat dilihat dari adanya sebuah komunitas Perhimpunan Fotografer Bali (PFB) dan ISI Denpasar yang memiliki program studi fotografi yang berlokasi di Kota Denpasar. Dilihat dari kondisi tersebut maka dibutuhkan sebuah wadah atau tempat bagi para peminat fotografi untuk melaksanakan pelatihan untuk mendapatkan sertifikasi profesi. Melalui metode pengumpulan data baik studi literature, wawancara dengan pengelola dan observasi kemudian dilakukan anilisis data didapatkan bahwa para peminat fotografi memerlukan fasilitas penunjang kegiatan fotografi khususnya tempat pelatihan dan uji kompetensi. Fasilitas penunjang ini berupa ruang kelas teori, ruang komputer, ruang studio fotografi indoor dan outdoor, galeri fotografi dan retail kamera. Sehingga, hasil penelitian ini berupa merancang fasilitas pusat fotografi di Denpasar dengan penerapan tema rancangan modern tropis.
Penerapan Tema Green Architecture pada Agrowisata Kopi Arabika di Desa Belantih, Kintamani
Authors: I Gede Soemantaranatha Eka Putra Wiratenaya  , Agus Kurniawan  , Ni Wayan Nurwarsih
Published: July 2023

Agrowisata adalah sebagai upaya pendidikan nonformal bagi masyarakat setempat sekaligus wisatawan yang melakukan kunjungan wisata. Pembelajaran yang berlangsung pada agrowisata sangat dibutuhkan sebab dapat menunjang proses belajar yang dilakukan di sekolah untuk mendalami pembelajaran serta berdampak pada peningkatan pemahaman akademik. Kopi arabika kintamani dari segi kualitas dan cita rasa dari telah diakui oleh negara penikmat kopi di dunia. Desa Belantih yang berada di Kecamatan Kintamani merupakan salah satu penghasil kopi arabika, yang dimana setiap Banjar/Dusun terdapat Subak Abian dan kelompok tani yang mengatur kegiatan usaha tani kopi arabika salah satunya ialah kelompok tani Dharma Kria. Kelompok tani Dharma Kria merupakan kelompok tani yang berada di Banjar Luahan, Desa Belantih yang terbentuk pada 2015 dengan jumlah anggotanya 34 orang. Pada era sekarang, di Bali kopi semakin banyak dinikmati oleh berbagai kalangan. Eksistensi kopi di Bali yang semakin meningkat terlihat dari fasilitas kedai-kedai kopi di Bali khusunya di Kecamatan Kintamani yang semakin bertambah namun, masih banyak yang kurang mengerti mengenai kopi arabika kintamani. Fasilitas yang menyediakan edukasi dan rekreasi yang dapat dijangkau oleh berbagai kalangan sangat diperlukan untuk mewadahi wisatawan  yang ingin lebih mempelajari proses biji kopi arabika kintamani mulai dari sejarah kopi arabika kintamani, penanaman, pemetikan, pengolahan, dan penyajian kopi arabika itu sendiri. Kegiatan rekreasi dapat dilakukan dengan menyebar fasilitas edukasi di beberapa titik agar wisatawan merasakan sensasi berjalan di tengah-tengah areal perkebunan kopi warga yang memiliki hawa sejuk. Metode pengumpulan data yang digunakan dalam antara lain studi literatur, observasi lapangan, dan survey
Wellness Sanctuary Sebagai Alternatif Penyembuhan Masyarakat Urban di Kabupaten Badung
Authors: Arya Duta Harjono  , I Ketut Sugihantara  , Ni Putu Ratih Pradnyaswari Anasta Putri
Published: July 2023

Sepanjang sejarah manusia yang hidup beriringan dengan alam dan budaya, manusia telah mencari kedamaian dan pemahaman yang lebih tentang perasaan emosional dalam kehidupan. Manusia terkadang lupa dengan bagaimana kesejahteraan hidup jasmani dan rohani selalu berkaitan. Kenyataan yang terjadi pada kondisi sekarang adalah manusia hidup di dalam masyarakat yang tidak memberikan jaminan lingkungan yang sehat. Aspek ini merupakan bagian dari keseimbangan kesehatan manusia yaitu Wellness. Dalam rangka menjaga keseimbangan kondisi ini, manusia harus dapat beradaptasi dalam menjaga kondisi fisik dan mental manusia terhadap lingkungannya. Dewasa ini, kebutuhan di kawasan perkotaan seperti Kabupaten Badung, penuh dengan adanya aktivitas yang dapat menimbulkan kelelahan fisik maupun mental. Perlu adanya ruang aman yang dapat memberikan suatu perawatan yang baik bagi masyarakat agar bisa mencari jalan keluar dalam menghadapi masalah seperti ini Diharapkan dengan adanya bangunan Wellness Sanctuary di Kabupaten Badung ini dapat menjadi ruang aman bagi klien yang ingin mendapatkan kedamaian dan kenyamanan. Membantu klien dalam menyelesaikan permasalahan emosional dan psikologis dengan mencari akar permasalahan yang dialami dengan berbagai berbagi cerita melalui pengalaman dan mengatasi permasalahan mental tersebut.
Redesain Pusat Konservasi Dan Edukasi Penyu Di Desa Serangan, Bali
Authors: Narayana Pramantya , Mertawijaya I Kadek , Parwata I Wayan
Published: July 2023

Desa Serangan terletak di Kecamatan Denpasar Selatan, desa Serangan termasuk salah satu wilayah yang memiliki potensi sumber daya kelautan. Penyu adalah satwa yang bermanfaat bagi kehidupan manusia, jika dikembangbiakan. Manfaat tersebut mencakup aspek peningkatan pertumbuhan ekonomi melalui sektor perikanan, menjaga keseimbangan mata rantai ekosistem, ilmu pengetahuan, pengembangan wisata edukasi. Pusat Konservasi Dan Edukasi Penyu merupakan suatu upaya untuk masyarakat pesisir pantai di Desa Serangan sebagai media edukasi terhadap peran masyarakat dalam menjaga dan melindungi ekosistem habitat penyu di Desa Serangan. Konservasi dan Edukasi Penyu ini dibentuk untuk menyelamatkan penyu dari pembantaian, perdagangan maupun konsumsi masyarakat lokal terkait kendala dan strategi adaptasi pada musim yang berbeda.  Pada pusat konservasi dan edukasi penyu terdapat beberapa permasalahan yaitu:  sistem zonasi, perletakan ruang, sirkulasinya, bangunan yang telah usang, dan material bangunan yang kurang layak sehingga perlu di redesain agar memenuhi kebutuhan pengunjung. Redesain ini menerapkan konsep Nature In Space yang diartikan alam dalam ruang dengan Tema Arsitektur Biophilic agar pengunjung yang datang dapat mereduksi stress dan merasa nyaman berada pada fasilitas ini.
CORRESPONDENCE OF HEISENBERG’S VIEWS WITH THE MULTIMODULAR CONCEPT OF A.V. AND L.A. BUROV
Authors: Rybakova I. A.
Published: July 2023

This article is devoted to a brief analysis of the views of the German physicist in their comparison with the concept of the metaphysical foundations of the universe of modern physicists Alexei Vladimirovich and Lev Alekseevich Burov. The object of the study is the main philosophical work of Heisenberg - the treatise “The Order of Reality” - and the work of the Drillers called “Metaphysical Status of physical Laws”. The metaphysical concepts of the multimodular reality of the mentioned authors are compared, and a brief historical basis for the emergence of these concepts is given. The substantiation of the importance of philosophical research in the field of physics and mathematics, and quantum physics is given - in particular. The necessity of further research of the issue is postulated considering the latest concepts in natural science within the framework of binary geometrophysics of Yu.S. Vladimirov. In conclusion, the importance of the modal (or multimodular) nature of reality is argued for the construction of a new, comprehensive picture of the world, within which it would be possible, finally, to understand the essence of quantum processes that determine reality, and to reach a fundamentally new level of philosophy of natural science.
COSMOLOGICAL SCALE FACTOR IN THE RELATIONAL APPROACH
Authors: Molchanov A. B.
Published: July 2023

In recent years, within the framework of the relational approach to the description of space-time and physical interactions, a number of studies have been carried out to substantiate the observed cosmological effects. In particular, it has been shown that the cosmological redshift described by the linear part of the Hubble law and the cosmic microwave background can be the result of contributions from emitted but not absorbed electromagnetic radiation. To describe the nonlinear part of the Hubble law, a logarithmic coordinate transformation was used, associated with the existence of a limiting observed distance, expressed by the gravitational radius of the observable Universe. The use of such a transformation must be justified by showing how it can be obtained in the derivation of space-time concepts for a system of a large number of emitters and absorbers. The article provides this rationale: it is shown that when deriving classical distances in the relational approach, there are two possibilities for determining the distance scale, they correspond to the scales of comoving and proper distances in cosmology, while the scale factor is expressed through the partition function of the configurations of emitters and absorbers.
DETECTION OF PROTON SELF-DECAY AS A SCIENTIFIC AND PHILOSOPHICAL PROBLEM
Authors: Godarev-Lozovsky M. G.
Published: July 2023

Incomparably more often, the nucleus of an atom decays earlier, and the proton continues to exist, but in extremely rare cases, the reverse sequence is possible: the self-decay of the proton precedes the moment of the decay of the nucleus. We believe that the mass of the primary nuclide 128Te with the longest and experimentally confirmed half-life should serve as the testable mass for detecting proton self-decay. The self-decay of a proton will differ from ordinary radioactivity by much more energy released during it.
PENGARUH CORPORATE GOVERNANCE (CG) TERHADAP KUALITAS LABA DENGAN MANAJEMEN LABA SEBAGAI VARIABEL INTERVENING (STUDI PADA PERUSAHAAN MANUFAKTUR SEKTOR INDUSTRI BARANG KONSUMSI DI BURSA EFEK INDONESIA TAHUN 2017-2020)
Authors: Puji r Desty , Rahayu Sri , Wiralestari Wiralestari
Published: July 2023

Penelitian ini bertujuan untuk memberikan bukti empiris pengaruh Corporate Governanceterhadap Kualitas Laba dengan Manajemen Laba sebagai Variabel Intervening pada perusahaan Manufaktur Sektor Industri Barang Konsumsi di Bursa Efek Indonesia (BEI) tahun 2017-2020. Sampel dalam penelitian ini adalah perusahaan Manufaktur Sektor Industri Barang Konsumsi yang terdaftar di Bursa Efek Indonesia (BEI) untuk tahun 2022 yang menerbitkan laporan tahunan periode 2017-2020. Proses pemilihan sampel dalam penelitian ini menggunakan metode Proportionate stratified random sampling. Analisis data yang digunakan dalam penelitian ini adalah path analysis menggunakan alat analisis SmartPLS 3.0. Hasil penelitian menunjukkan bahwa Corporate Governance berpengaruh terhadap kualitas laba. Corporate Governance berpengaruh terhadap manajemen laba. Manajemen laba tidak berpengaruh secara negatif terhadap kualitas laba. Corporate Governance terhadap kualitas laba dengan manajemen laba sebagai variabel Intervening tidak berpengaruh.
Analisis Sistem Pengendalian Intern Terhadap Kredit Macet Bank Perkreditan Rakyat (BPR) Kota Jambi
Authors: Arum R Dwi , Wahyudi Ilham , Wijaya R Rico
Published: July 2023

Penelitian ini bertujuan untuk melihat bagaimana sistem pengendalian intern terhdapa kredit macet pada Bank Perkreditan Rakyat di Kota Jambi. Sistem pengendalian diukur dengan menggunakan skala simantic differensial dengan interval 1-7 dan kredit macet diukur dengan skala rasio.Penelitian ini menggunakan sampel perusahaan Bank Perkreditan Rakyat yang terdaftar di OJK dan yang berada di wilayah Kota Jambi. Teknik pengemabilan sampel yang digunakan teknik sampling jenuh, sampel yang digunakan 14 perusahaan dengan total 140 responden.  Teknik  analisis data dalam penelitian ini adalah statistik deskriptif dan analisis  regresi linear berganda. Software yang digunakan untuk olah data adalah SPSS versi 22 for windows. Hasil pengujian hipotesis sebagai berikut. Pertama, untuk mengetahui bagaimana sistem pengendalian intern terhadap kredit macet pada Bank Perkreditan Rakyat di Kota Jambi. Kedua, melihat pengaruh sistem pengendalian intern terhadap kredit macet pada Bank Perkreditan Rakyat di Kota Jambi.
Fetal soft tissues assessment by 2D ultrasound for macrosomia screening: a systematic review.
Authors: Oros Daniel , Lerma Diego , Aguerri Ana , Pardina Gema , Paules Cristina , Lerma-Irureta David , Ruiz-Martinez Sara
Published: July 2023

Background Management of suspected large for gestational age
(LGA) fetuses remains unclear because the lack of accuracy of ultrasound
estimated fetal weight. Objectives To assess the methodology of
studies reporting 2D ultrasound assessment of fetal soft tissues with
the aim of improving the screening of LGA fetuses. Search
strategy This was a systematic review of observational studies. A
search for relevant articles was performed in MEDLINE, EMBASE, CINAHL,
Web of Science (from inception to 31 January 2022), and references of
the retrieved articles. Two authors independently selected studies and
assessed the risk of bias and extracted the data. Selection
criteria Studies on fetal soft tissues measurements used alone or in
combination to create a new estimated fetal weight (EFW) formula, to
improve the screening for LGA fetuses. Data collection and
analysis Studies were scored using a predefined set of independently
agreed methodological criteria and an overall quality score was assigned
for study design, statistical analysis, and reporting methods.
Main results Thirty-two studies met the inclusion criteria (ten
for a new EFW algorithm and twenty-two for an isolated parameter used as
cut-off for LGA fetuses detection). The highest potential bias were
noted in the following fields: sample size estimation, diabetes
description, report of perinatal outcomes, number of measurements taken,
and multicenter study. Only eight out of thirty-two studies scored over
70% in design quality. Conclusions There is a need for the
standardization of methodologies for soft fetal tissues measurements and
for the development of reference standards, which can be correctly
interpreted and applied in clinical practice. We propose a set of
suggestions for this purpose.