bluuebunny/crossref_metadata_2025 huggingface dataset:
Perancangan dan Pembangunan Sistem Informasi Geografis Pemetaan Lokasi Penyedia Jasa Servis Perangkat Komputer di Wilayah Kota Tangerang Selatan Berbasis Web
Authors: Pamungkas Abiyan Pasya , Yulianti Yulianti
Published: July 2024

Dengan meningkatnya kegiatan belajar dari rumah dan bekerja dari rumah selama masa pandemi COVID-19 tentu berpengaruh juga pada peningkatan pengguna perangkat komputer seperti laptop dan desktop PC. Penyedia jasa servis perangkat komputer merupakan jasa yang banyak diminati terutama oleh para pengguna perangkat komputer yang baru menggunakan perangkat komputer di masa pandemi ini namun, sama seperti pelaku usaha lainnya pelaku UMKM jasa servis perangkat komputer juga mengalami penurunan jumlah pelanggan yang mengakibatkan penurunan omset di awal pandemi COVID-19 karena kurangnya kegiatan promosi di masa pandemi oleh pelaku usaha jasa servis perangkat komputer. Dengan adanya permasalahan tersebut, maka perancangan sistem informasi geografis pemetaan lokasi-lokasi penyedia jasa servis perangkat komputer cukup memungkinkan guna memberi kemudahan kepada masyarakat yang ingin melakukan perbaikan pada perangkat komputernya dan membantu para penyedia jasa servis perangkat komputer dalam mempromosikan jasanya, pengembangan sistem informasi geografis  ini menggunakan metode Waterfall, dan untuk bahasa pemrogramannya menggunakan PHP dan Database MySQL.
Klasifikasi Opini Masyarakat terhadap Jasa Ekspedisi J&T Express pada Media Sosial Twitter dengan NaÃ¯ve Bayes
Authors: Ansyahry Bramantyo Ridho , Al Amin Imam Husni
Published: July 2024

Dengan maraknya transaksi penjualan online melalui e-commerce dan media sosial, membuat dampak yang berefek pada berubahnya perilaku konsumen. Hal ini mengakibatkan banyaknya penilaian sentimen dari para pengguna jasa ekspedisi tersebut. Jasa ekspedisi kini menjadi salah satu jasa yang paling diminati. Perusahaan jasa pengiriman yang beroperasi di Indonesia salah satunya adalah J&T Express. Melalui media sosial, khususnya Twitter dengan jumlah pengikut hingga 154.439 dan jumlah tweet hingga 103.100, seorang pengguna dapat membentuk opini terhadap kinerja J&T Express dan mendapatkan data sebanyak 1694 tweet. Algoritma pembelajaran mesin diperlukan untuk memungkinkan analisis sentimen dapat diklasifikasikan. Salah satunya adalah algoritma Naive Bayes. Sebelum menjalankan proses klasifikasi, diperlukan proses preprocessing agar dataset dapat dikenali oleh sistem. Berdasarkan pengujian yang dilakukan, didapatkan hasil akurasi sebesar 84%, precision sebesar 76%, dan recall sebesar 87%. Hasil dari riset ini menampilkan bahwa data dapat digunakan sebagai dasar mengevaluasi keputusan bisnis.
Optimizing calliandra (Calliandra calothyrsus) biomass pellets: Impact of particle size and bark composition
Authors: Wahyu Abdul Rahman  , Suri Intan Fajar , Indra Gumay Febryano  , Saputra Bagus , Duryat  , Hidayat Wahyu
Published: July 2024

Calliandra biomass pellets offer a promising alternative energy source to replace fossil fuels. Typically, these pellets are produced by directly processing the stem and bark of the calliandra (Calliandra calothyrsus) plant without separation, aiming for manufacturing efficiency. This study investigated the quality differences between calliandra biomass pellets with and without bark and varying particle sizes. Particle sizes used were 20 mesh, 40 mesh, and 60 mesh. The pellets were made using a 12 mm diameter biomass pellet mold and a manual hydraulic press with a pressure of 3 tons. Characterization involved assessing proximate analysis, calorific value, physical and mechanical properties, and Fourier Transform Infrared analysis. The test results were compared with biomass pellet standards from Indonesia, Japan, Korea, and Germany. Results indicate that bark affects several properties, with higher ash content observed in pellets with bark due to the higher mineral content in bark. Volatile matter decreases with finer particle size, influencing combustion rate. Moisture content is higher in pellets with bark, impacting combustion efficiency and smoke production. Fixed carbon values are influenced by moisture and volatile matter content. Calorific values are generally higher in pellets without bark and smaller particle sizes. Density and compressive strength increase with decreasing particle size. FTIR analysis reveals differences in functional groups between pellets with and without bark, indicating variations in chemical composition. Overall, this research provides insight into the potential of calliandra biomass pellets with bark and without bark along with particle size as a renewable energy source.
Reducing, reusing, and recycling in the furniture industry: A mini-review
Authors: PraÅ‚at Barbara , Owsian Anna , RogoziÅ„ski Tomasz
Published: July 2024

This study explores sustainable practices within the furniture industry, focusing on the principles of reduce, reuse, and recycle. Through a comprehensive review of scholarly literature retrieved from databases like Scopus, Web of Science, and Google Scholar a moderate corpus of articles is identified. The analysis reveals a predominant emphasis on strategies aimed at minimizing resource consumption, extending product lifespans, and optimizing material recovery. While reduce, reuse and recycle serve as foundational pillars of sustainable furniture production, the literature also highlights complementary principles such as "rethink" and "refuse," urging critical reassessment and rejection of unsustainable practices. Despite the diversity in research interests and methodologies, the synthesis of findings underscores the need for standardization and comprehensive approaches to address environmental challenges throughout the furniture lifecycle. The study advocates for further research and collaboration to drive meaningful progress towards a more sustainable future for furniture production and consumption. This abstract encapsulates the key findings and implications of the study, providing a concise overview of the state of research on sustainable practices within the furniture industry. The aim of this short review is to analyse the scientific articles and their quantity relating to ecodesign in the furniture industry, with particular emphasis on the principles of reduce, reuse and recycle, as well as complementary concepts such as â€˜rethinkingâ€™ and â€˜refuseâ€™.
ДІАГНОСТИКА ІНТЕНСИВНОСТІ ДІЯЛЬНОСТІ З МЕТОЮ ЗАБЕЗПЕЧЕННЯ ЗБАЛАНСОВАНОСТІ РЕЗУЛЬТАТИВНОСТІ ПІДПРИЄМСТВ ТУРИСТИЧНОЇ ІНДУСТРІЇ
Authors: Трухачова К.В.
Published: July 2024

Стаття присвячена актуальній проблемі забезпечення збалансованої результативності діяльності підприємств туристичної індустрії, яка в першу чергу, полягає в діагностиці інтенсивності їх діяльності, саме – отриманими за певний період діяльності результатів. У статті діагностика інтенсивності діяльності підприємств туристичної індустрії здійснюється шляхом оцінювання, визначення рівня та встановлення оптимального значення їх результативності. Дослідження визначає підхід до оцінювання результативності діяльності будь-якого підприємства, не тільки туристичної індустрії. Результати дослідження слугують базою для визначення напрямку управлінських дій щодо подолання неузгодженостей складових результативності з метою забезпечення її збалансованості.
المنمنمات العربية -المنمنمات السياسية لصقلية إنموذجاً-
Authors: عكلة أ.م.د منال حسن
Published: July 2024

المنمنمات هي عبارة عن رسوم توضيحية، انتشرت في مجموعة من المؤلفات، وكان الغرض منها، تسهيل فهم النصوص المكتوبة أو توضيحها، على شكل لوحة فنية تصويرية، ازدهرت في بداية الامر في العالم الاسلامي في فترة الفتوحات، ولما نشطت عملية الفتوحات الاسلامية التقت مع الدول الاوربية لاسيما البلدان التي حكمها العرب المسلمون ومنها صقلية، التي حكمها الفاطميون(297هـ-484هـ/910-1091م)[ حكم الفاطميون صقلية عن طريق ولاتهم الكلبيين وغيرهم لمدة قرنين بعد ان انشأوا اسطولاً ضخماً هدفه حماية البلاد من الهجمات البيزنطينية ثم دافع عنها بعد ذلك في الحروب الصليبية، كما كان هدفهم نشر المذهب الاسماعيلي وتحقيق العديد من طموحاتهم خلال مدة وجيزة.فحكم خلال تلك الفترة ولاة من قبل الفاطميين في صقلية فكان عصر الولاة (296-336هـ/908م-947م) ، ثم حكم الامراء الكلبيين، بأسم الدولة الفاطمية]  (الحموي، ١٩٩٥، صفحة 392) (الادريسي، 1989، صفحة 762).
       وامتاز الفنان العربي في صقلية ببصمته المميزة في هذا الفن مما ادى الى ازدهاره في بقية الدول، على الرغم من بساطة الاسلوب التي اتسمت به فن المنمنمات في البدء، الا انها تطورت مع مرور الزمن واصبحت تمتاز بالواقعية والتعبيرية، فهو فن يدعو الى استلهام الماضي واعادة احياءه.
عُد فن المنمنمات السياسية واحد من الموضوعات المهمة التي سلطنا الضوء عليها في هذا البحث، لما لها من اهمية تاريخية، كون ان المنمنمات ذات الموضوعات السياسية أعُتبرت كوثيقة يتم الاعتماد عليها في المراجع التاريخية والسياسية وغيرها.
 
    مشكلة البحث كانت في صعوبة الحصول على المعلومات عن صقلية لاسيما المترجمة منها عن فترة الحكم الاسلامي وما بعده، لقلة المصادر المترجمة عنها. بينما اهمية البحث تتجلى في جمالية اعادة استخدام هذا الفن في المؤسسات التعليمية والعمرانية لأهميتها التاريخية كونها تعكس حضارة وتاريخ بلد بأسره والجمالية كونها ذا قيمة فنية عالية في الالوان والافكار والرسومات وغيرها،وقد تم استخدام المنهج التاريخي والمنهج الوصفي في هذه الدراسة. وقد تم اختيار هذا الموضوع كونه يعكس اهمية المنمنمات السياسية ودورها في الحصول على المعلومات التاريخية من خلالها.
The Position of the Lebanese Shia Community on the Israeli Invasion of Lebanon in 1982
Authors: Naeem Prof. Dr. Ali Hussein , Ali Zahara raheem
Published: July 2024

اتضح العمليات العسكرية التي تقوم بها الفصائل المسلحة الفلسطينية ضد (اسرائيل) انطلاقا من الاراضي اللبنانية ، هي السبب المباشر لاجتياح لبنان في حزيران عام 1982 ، وكان هدف الغزو طرد منظمة التحرير الفلسطينية من لبنان وإنهاء الوجود العسكري السوري فيه، وإيجاد نظام متعاون مع اسرائيل مستعد لتوقيع معاهدة "سلام" مع تل أبيب، ويمكن القول أنها حققت بعض أهدافها، في مقابل ذلك لم يمر الاجتياح دون مقاومة فقد جوبه بتصدي وشجب واستنكار على مختلف الاصعدة ومن بعض الطوائف اللبنانية ، ولاسيما الطائفة الشيعية التي تبين انها رافضة بشكل قاطع لهذا الغزو من خلال بياناتها واستنكارها فضلا عن حمل السلاح والمقاومة العسكرية.
Friksi Perdagangan dan Korelasinya Terhadap Karakteristik Perdagangan Pada Data Keuangan Berfrekuensi Tinggi Di Bursa Efek Indonesia
Authors: Nurhayati Immas
Published: July 2024

The sources of trading friction are studied, robust empirical measures of friction are provided. Four distinct measures of trading friction are computed from transactions data for 200 IDX stocks. Each observation for a company is an average over the 245 daily observations.All friction measures are expressed as a percentage of the average price (mentioned as the proportional half spread). The degree to which the various measures of trading frictions are associated with each other and with trading characteristics of stocks is examined. All the total friction measures are strongly related to the same variables in the same way. For association of trading friction with trading characteristics, the independent variables are the log of the average daily dollar volume, the stock's, the log of the average closing price and the log of the average number of trades per day. Quoted, effective and traded half spread measures decrease in number of trades, average daily dollar volume and stock price, and these variables are statistically significant in Indonesian Stock Exchange.
DEWAN REDAKSI
Authors: User Cover
Published: July 2024

Dewan Redaksi Neraca
Pengembangan Teknologi Tepat Guna Dalam Pengelolaan Sampah Plastik
Authors: Hariansyah, M.T. Dr. M. , Eldine Achyar
Published: July 2024

Sampah belum tertangani dengan baik. Selama ini sampah tersebut dibuang ke Tempat Pembuangan Akhir (TPA), sehingga sampah akan mencemari tanah, air dan udara, serta lingkungan hidup. Salah satunya adalah sampah an organic seperti plastik kantong kresek, yang dapat terurai hingga 450 tahun. Sehingga perlu upaya untuk mengolah sampah menjadi barang yang berguna, seperti souvenir dan vavin blok.Tujuan yang diharapkan (a) menghasilkan peralatan teknologi tepat guna untuk mengelola sampah plastik menjadi vavin blok, (b) meningkatkan pendapatan ekonomi keluarga. Metode yang diterapkan diawali dengan pemilahan sampah, pemanasan plastik, pengepresan secara konvensional dan pengujian laboratorium serta teknik pemasaran.Hasil yang diperoleh berupa bahan vavin blok berbentuk balok, berukuran (5x10x20)cm, dan berat satu unit vavin blok 0,27 kg, memerlukan kantong kresek sebanyak 0,3 kg. Berdasarkan analisis biaya produksi maka diperkiranan penjualan untuk satu (1) unit seharga Rp 2.000, Hasil uji tekan mencapai 230 kg/cm2, dan diharapkan mampu untuk menggantikan vavin blok yang terbuat dare bahan campuran pasir dan semen.
Kepemimpinan Koperasi Syariah Masa Depan
Authors: Hurriyaturrohman Hurriyaturrohman
Published: July 2024

Secara implementatif, Koperasi syariah baik sebagai gerakan ekonomi rakyat maupun sebagai badan usaha berperan serta untuk mewujudkan masyarakat yang makmur, sejahtera berdasarkan UUD 1945 dan berdasarkan Pancasila dalam tata kelola perekonomian Nasional yang disusun sebagai usaha bersama berdasarkan atas asas kekeluargaan dan syariah Islam yaitu Al-Quran dan As-Sunnah dengan saling tolong menolong (ta'awun) dan saling menguatkan (takaful) dan dilandasi dengan semangat gotong-royong.Peran dan fungsi kepemimpinan koperasi syariah guna menghadapi persaingan usaha masa depan harus tetap memperhatikan kaidah dasar organisasi koperasi yang memposisikan sebagai badan usaha yang beranggotaan orang-seorang atau badan hukum koperasi dengan melandasi kegiatannya berdasarkan prinsip koperasi syariah sekaligus sebagai gerakan ekonomi rakyat yang berdasarkan atas asas kekeluargaan. Keyword:  Koperasi syariah, Siddiq, amanah, Tabliqh, Fathanah
Analisis Cost Of Capital Sebagai Alternatif Sumber Pendanaan Eksternal (Studi Kasus Pada PT. Bank Tabungan Negara (Persero), Tbk)
Authors: Yudiana Yudiana , Mulyana Leman
Published: July 2024

Pada umumnya komponen cost of capital atau biaya modal perusahaan terdiri dari biaya modal sendiri (cost of equity) dan biaya hutang (cost of debt). Cost of equity merupakan sumber dana yang dibentuk atau dihasilkan sendiri dari dalam perusahaan. Sedangkan cost of debt adalah sumber dana yang dihimpun dari luar perusahaan. Keberadaan pendanaan tersebut dapat membantu perusahaan untuk melakukan peningkatan aktivitas operasional dan produksinya. Cost of debt, akan menanggung resiko bagi perusahaan berupa beban bunga yang mengikuti pinjaman atau hutang tersebut dan berdampak pada tingkat leverage perusahaan.Penelitian ini bertujuan menganalisis sejauh mana kemampuan perusahaan dalam mengelola aset sehingga menghasilkan pendapatan yang mampu menutupi kewajiban dan beban bunga. Serta untuk menganalisis berapa besar tingkat leverage operasi dan leverage keuangan perusahaan dari tahun 2010 sampai dengan 2014.Hasil analisis yang diperhitungkan melalui debt ratio, bahwa kemampuan perusahaan dalam mengelola aset untuk menutupi kewajiban perusahaan sangat beresiko, karena 91% perusahaan dibelanjai oleh hutang. Sedangkan keuntungan yang dihasilkan untuk menutupi beban bunga dikatakan dalam kondisi kurang baik karena time interest earned ratio yang dihasilkan relatif kecil dengan rataan sebesar 0,38 kali. Selain itu hasil analisis leverage operasi menunjukkan penurunan yang begitu drastis, yaitu dari leverage operasi 5,29x menurun sampai pada titik hasil -1,47x. Sedangkan analisis leverage keuangan menunjukkan hasil yang fluktuatif yaitu dengan rataan 0,66x.
Pengujian Substantif Laporan Internal Audit Terhadap Piutang Usaha Pada PT. Cahaya Buana Intitama
Authors: Yudiana Yudiana , Budiarto Arif
Published: July 2024

Masalah penjualan sebagai salah satu sumber pendapatan perusahaan perlu mendapatkan perhatian besar. Perusahaan harus mendapatkan kepastian tentang penerimaan hasil penjualanya, karena hal ini secara langsung dapat mempengaruhi kelangsungan hidup perusahaan. Laba tidak hanya dapat dicapai dengan peningkatan jumlah persediaan barang atau jasa, tetapi peningkatan ini harus diikuti pula dengan peningkatan penjualan. Saat ini perusahaan yang sedang berkembang menuntut pengamanan yang lebih profesional dibidang manajemen. Manajemen perusahaan harusmenyusun struktur pengendalian dalam rangka membantu perusahaan untuk mencapai tujuan yang diinginkan. Tujuan utama pengendalian intern adalah untuk mengamankandan melindungi baik catatan aktiva perusahaan serta untuk menghasilkan data yang andal yang dapat digunakan untuk mengambil keputusan penggunaan jasa auditor intern adalah untuk memeriksa laporan keuangan dan catatan akuntansi perusahaan apakah telahsesuai dengan standar akuntansi keuangan, untuk mengetahui penyimpangan dan kecurangan yang ditemukan dan juga untuk mengetahui kelemahan pada strukturpengendalian intern, beserta sasaran-sasaran perbaikan yang dapat digunakanpertimbangan dalam pengambilan keputusan bagi pihak manajemen. Adapun tujuan penelitian ini adalah 1). Untuk mengetahui apakah terdapatpengendalian intern yang baik dalam perencanaan dan pelaksanaan piutang, 2) Untuk mengetahui prosedur pemeriksaan audit terhadap pengendalian piutang, 3) Untuk mengetahui pengaruh audit terhadap efektifitas piutang perusahaan. Jenis penelitian yang digunakan adalah deskriptif (analisis) dengan metode penelitiannya adalah studi kasus.Sedangkan teknik penelitian yaitu non statistik observasi. Hasil dari pembahasan BAB IV secara keseluruhan adalah: 1). Perusahaan mempunyai sistem pengendalian intern yang baik dalam transaksi penjualan kredit, dari mulai pesanan dari konsumen hingga pencatatan pelunasan, dengan demikian segala bentukpenyimpangan ataupun kesalahan dapat dihindari, 2). Terdapat beberapa temuan ketika dilakukan pengujian substantif, ada perbedaan jumlah piutang yang tertera pada Neracadengan ketika ditelusuri kedalam Buku Besar melalui prosedur audit awal, dilihat dari perhitungan rasio yang digunakan pengendalian intern yang baik ternyata tidak menjaminkondisi yang baik dilapangan,3). Perusahaan telah menerapkan standar akuntansi keuangan yang berlaku dalam penyusunan piutang pada neraca dari mulai pencatatan piutang, pengakuan piutang, basis akuntasi yang digunakan, penilaian piutang.Dari hasil penelitian dapat diketahui bahwa penerapan sistem yang baik perlumendapatkan pengawasan secara periodik untuk memastikan bahwa tujuan perusahaantelah berjalan dengan sesuai.
SIMULASI SAHAM PADA JAKARTA STOCK EXCHANGE DESEMBER 2005
Authors: Nurhayati Immas
Published: July 2024

Sifat ketidakpastian keputusan investasi di masa mendatang disebabkan adanyaresiko yang dihadapi investor dalam upaya mendapatkan return (imbal hasil). Diversifikasi saham merupakan salah satu upaya untuk meminimumkan tingkat resiko. Mengapa pemodal tertarik untuk melakukan diversifikasi dan membentuk portofolio investasi? Jawaban klasiknya adalah bahwa diversifikasi (atau pembentukan portofolio) akan mengurangi resiko.Pepatah asing mengatakan “smart investor do not put all their eggs in one basket “. Penulis mencoba mensimulasikan secara sederhana bagaimana berinvestasi dalam saham dengan menerapkan berbagai teori mengenai pembentukan portofolio sehingga investasi dalam saham memberikan keuntungan bagi investor. Data yang digunakan dalamstudi ini merupakan data sekunder yang diperoleh dari publikasi Jakarta Stock Exchange selama periode Oktober sampai Desember 2005. Hasil simulasi, dengan modal awal sebesar satu milyar (1.000.000.000) yang terebar dalam beberapa sekuritas memberikan return kumulatif sebesar 1.202.700.000 atau sekitar 20,31%.
Efeitos de uma História de Reforço Continuo Sobre o Seguimento de Regras
Authors: de Albuquerque Luiz Carlos ,   Universidade Federal do Pará, Alcantara dos Reis Adriana , Paiva Paracampo Carla Cristina ,   Universidade Federal do Pará,   Universidade Federal do Pará
Published: July 2024

Este estudo investigou, com 16 universitários, distribuídos em dois experimentos, os efeitos de uma história de reforço contínuo sobre o seguimento de regras. Utilizou-se um procedimento de escolha segundo o modelo, com três estímulos de comparação; a tarefa consistia em apontar cada um dos três estímulos de comparação, em seqüêncie, de acordo com a dimensão em comum com o modelo. As regras especificavam qual seqüência deveria ser emitida. O seguir regra discrepante das contingências de reforço não era reforçado; o seguir regra correspondente era reforçado em CRF. Nos dois experimentos essas regras eram apresentadas na ordem correspondente-discrepante ou na ordem discrepantecorrespondente- discrepante, dependendo da condição experimental. Em um segundo experimento, os participantes eram expostos a uma história de reforço contínuo antes de serem expostos às regras. Todos os participantes do Experimento 1 (n = 8) seguiram regra e sete dos oito do Experimento 2 abandonaram o seguimento da regra discrepante e passaram a responder de acordo com suas histórias experimentais. Os resultados têm implicações para a identificação das variáveis envolvidas no seguimento de regras.
MENINGKATKAN PERTAHANAN LAUT: KEPEMIMPINAN STRATEGIS DALAM MENINGKATKAN PERTAHANAN ALUR LAUT KEPULAUAN INDONESIA (ALKI)
Authors: Narahara Sean
Published: July 2024

Indonesia, salah satu dari 45 negara kepulauan di dunia, memiliki wilayah laut yang luas dan posisi strategis antara Samudera Hindia dan Samudera Pasifik. Dengan 17.504 pulau dan luas wilayah laut 3,5 juta km2, Indonesia memiliki potensi besar dalam pertahanan dan konektivitas maritim. Alur Laut Kepulauan Indonesia (ALKI) merupakan jalur transportasi internasional yang vital dan membutuhkan kepemimpinan strategis untuk meningkatkan pertahanan lautnya. Penelitian ini bertujuan untuk menganalisis kepemimpinan strategis dalam meningkatkan pertahanan ALKI, serta mengidentifikasi langkah-langkah yang diperlukan untuk memperkuat keamanan maritim dan memastikan kelancaran jalur perdagangan internasional yang melintasi wilayah perairan Indonesia. Metode penelitian yang digunakan meliputi studi literatur, analisis kebijakan maritim, dan evaluasi data sekunder terkait kondisi geografis, luas wilayah, serta dinamika keamanan dan perdagangan di ALKI. Hasil penelitian menunjukkan bahwa kepemimpinan strategis yang efektif berperan penting dalam meningkatkan pertahanan ALKI. Identifikasi potensi ancaman, peningkatan kerjasama internasional, dan modernisasi armada laut adalah langkah-langkah yang perlu dilakukan. Selain itu, pemanfaatan teknologi pengawasan dan peningkatan kapasitas personel keamanan laut juga terbukti krusial dalam menjaga keamanan jalur perdagangan ini. Kepemimpinan strategis yang kuat dan terarah sangat diperlukan untuk meningkatkan pertahanan ALKI. Dengan strategi yang tepat, Indonesia dapat memastikan keamanan dan kelancaran jalur transportasi internasional, yang pada gilirannya memperkuat posisi Indonesia sebagai pusat perdagangan global dan meningkatkan pertahanan maritim nasional. Implementasi langkah-langkah tersebut akan memperkuat keamanan maritim, mendukung ekonomi nasional, dan meningkatkan kerjasama internasional.
ONE CRISIS WITHIN ANOTHER: COPING WITH DOMESTIC VIOLENCE DURING THE COVID-19 PANDEMIC
Authors: Che Ha Norbani , Che Hashim Rosmawanı , Karim Noorfara Atilia , Othman Sajaratulnısah
Published: July 2024

Although Covid-19 has aggravated and initiated mental health concerns to domestic violence (DV) victims, there is a worrying lack of measures meant to DV victims in the context of a pandemic. This study aims to (a) identify and understand the types of domestic violence experienced by women during the pandemic, as well as the consequences in social and work contexts, (b) assess the coping strategies of abuse victims, and (c) identify the gap in government and organizational support for DV victims. A semi-structured questionnaire was used to conduct in-depth interviews with 19 Malaysian women. NVIVO 8 was utilised for thematic analysis. The qualitative findings suggest that there was an increase in gender-based violence in Malaysia during the lockdown, with psychological abuse appearing to be the most prevalent. Despite the difficulties, the majority of victims who were exploited during the lockdown did not report the abuse and instead employed avoidance-based coping mechanisms. Negative passive-avoidance and negative active-avoidance were the most prevalent coping mechanisms. The findings also indicate that eradicating domestic violence would necessitate a broader, more coordinated, and integrated system of government and organizational support.
This is the first study to evaluate the serious impact of domestic violence on working Malaysian women in the wake of the Covid-19 crisis. As a result, it provides a wealth of information and could serve as a firm basis for designing effective psychological interventions for women in countries with similar cultural and societal norms to Malaysia.
SYSTEMS MODELLING: QUEUING SYSTEM TO OPTIMIZE WORKLOAD
Authors: PAKSI DÁVID , KMEŤ TIBOR , CZAKÓOVÁ KRISZTINA , TAKÁČ ONDREJ
Published: July 2024

For pharmacists to fulfil their roles in the provision of pharmaceutical healthcare, it is necessary to ensure the effective organization of the work of individual healthcare professionals. We performed measurements at a selected pharmacy, which, among other things, allowed us to determine the time between people arriving and the average number of pharmaceuticals purchased. Using the available measurement data, we created a queueing system that can simulate the operation of a pharmacy. The system can save time for other pharmacists to fully devote themselves to other activities related to the provision of pharmaceutical healthcare, such as consultation, preparation of medicines in the laboratory, back-checking of prescriptions, or stock control.
KÜRESEL TEDARİK ZİNCİRLERİNDE RİSK YÖNETİMİ: JEOPOLİTİK, DOĞAL VE EKONOMİK FAKTÖRLERİN ETKİSİ
Authors: Bülte Hüseyin
Published: July 2024

Bu çalışma, küresel tedarik zincirlerindeki risk yönetiminin jeopolitik, doğal ve ekonomik faktörlerin etkisi altında nasıl şekillendiğini derinlemesine incelemektedir. Özellikle bu faktörlerin tedarik zinciri üzerindeki aksaklıklara yol açıp açmadığı ve bu aksaklıkların niteliği üzerine odaklanmaktadır. İklim değişiklikleri, jeopolitik riskler ve ekonomik krizler gibi dış etkenlerin tedarik zincirlerinin savunmasızlığını ortaya koyması, bu alandaki çalışmaların önemini artırmaktadır. Bu bağlamda YÖK Tez, Pubmed, Dergipark, Mendeley gibi internet veri tabanları incelenerek literatür araştırması gerçekleştirilmiştir. Tedarik zinciri risk yönetiminin sadece bozulmaları değil, aynı zamanda paydaşların olası tepkilerini de dikkate alması gerektiği belirtilmektedir. Sonuç olarak, tedarik zinciri risk yönetimi alanındaki literatürün hala gelişmekte olduğuna ve bu alanda genellenebilir özellikleri yüksek olan deneysel çalışmalara ihtiyaç duyulduğuna işaret edilmektedir.
KIRILGANLIK PERSPEKTİFİNDE İKİZ VE ÜÇÜZ AÇIKLARIN SÜRDÜRÜLEBİLİR BÜYÜMEYE ETKİLERİ
Authors: Akçayır Ömer , Akın Fatih
Published: July 2024

Çalışmada, kırılgan beşli ülkeleri örnekleminde, ikiz ve üçüz açık hipotezi varsayımıyla cari açıkların ekonomik büyüme üzerindeki etkileri 1989-2022 yılları örnekleminde panel regresyon analizi ile araştırılmıştır. Son 12 yıl ortalamasına göre Brezilya, Güney Afrika, Endonezya ve Hindistan ikiz açık verirken Türkiye üçüz açık vermektedir. Kırılgan beşli ülkelerinin büyüme oranlarında en yüksek volatilitenin Türkiye’de olduğu ve genel olarak hepsinin volatilitesinin oldukça yüksek olduğu görülmektedir. Büyüme oranlarının taşıdığı yüksek standart sapmanın sürdürülebilir büyüme açısından riski ve kırılganlığı artırdığı öngörülmüştür. Ampirik analizde birim kök içermeyen tamamı durağan serilere uygulanan Panel EKK sonuçlarına göre, kırılgan beşli ülkelerinde cari işlemler dengesinin GSYİH içindeki payı 1 puan azaldığında (cari açık/GSYİH arttığında) aynı dönemde ekonomik büyüme yaklaşık 0.19 puan artmaktadır. Türkiye’nin dâhil edilmediği modellerde katsayının mutlak değerce azaldığı gözlenmektedir. Kırılgan ekonomilerin tamamının ekonomik büyümeyi sürdürebilmesi için göstermiş olduğu çabanın cari dengeyi olumsuz yönde bozduğu gözlenmektedir. Türkiye’de ise büyüme ve cari açık ilişkisi üçüz açığın baskın etkisi nedeniyle daha güçlüdür. Son yıllarda birçok kişi ve kurum tarafından kırılgan beşli ülkelerinin en kırılganının Türkiye olduğu iddia edilmektedir. Hem üçüz açık endeks değerlerine ve yüksek volatiliteye hem de regresyon sonuçlarına bakıldığında Türkiye’nin kırılgan beşli ülkeleri içinde en kırılgan ekonomi olduğu yorumu yapılabilmektedir.
Eficacia del procedimiento sancionador en casos de acoso laboral en el sector privado en el Ecuador
Authors:   Universidad Tecnológica Indoamérica, Fares Peñafiel Joel Jonas , Morales Navarrete Martha Alejandra ,   Universidad Tecnológica Indoamérica
Published: July 2024

El maltrato y la dominación jerárquica en el trabajo son problemas persistentes a pesar de los avances en derechos laborales. Este estudio evalúa la eficacia del mecanismo sancionador contra el acoso laboral en Ecuador, utilizando un enfoque cualitativo y un diseño descriptivo no experimental transversal. Se revisaron legislaciones nacionales, jurisprudencia, tratados internacionales y artículos académicos para analizar el procedimiento sancionador en el sector privado ecuatoriano. El problema central es la prevalencia del acoso laboral y la necesidad de un mecanismo eficaz para sancionarlo y proteger a las víctimas. El objetivo general es evaluar cómo el mecanismo sancionador actual aborda el acoso laboral y su impacto en la protección de los derechos laborales. Los resultados indican que el procedimiento sancionador ha mejorado significativamente la identificación y denuncia de casos de acoso laboral. El Ministerio de Trabajo recibe denuncias regularmente, reflejando una mayor conciencia y disposición de los empleados para reportar comportamientos abusivos. Sin embargo, existen desafíos en términos de recursos y supervisión para garantizar la aplicación estricta y constante de las sanciones. Las conclusiones destacan que la implementación del mecanismo sancionador ha proporcionado un marco estructurado para la investigación y resolución de denuncias, fortaleciendo la protección de los derechos laborales. No obstante, se necesita una evaluación continua de la accesibilidad y eficacia del proceso legal para asegurar que las víctimas no enfrenten obstáculos significativos. La legislación ecuatoriana, respaldada por este mecanismo, ha mejorado el apoyo y justicia para las víctimas de acoso laboral, pero aún requiere ajustes para optimizar su efectividad y alcance.
The impact of repeated temperature cycling on cryopreserved human iPSC viability stems from cytochrome redox state changes
Authors: Okuda Jun , Watanabe Namiko , Nakamura Tetsuji , Mizushima Kenta , Xi Heqi , Kumamoto Yasuaki , Fujita Katsumasa , Kino-Oka Masahiro
Published: July 2024

Human induced pluripotent stem cells (hiPSCs) are an attractive cell source for regenerative medicine. For its widespread use as a starting material, a robust storage and distribution system in the frozen state is necessary. For this system, managing transient warming during storage and transport is essential, but how transient warming affects cells and the mechanisms involved are not yet fully understood. This study examined the influence of temperature cyclings (from −80°C to −150°C) on cryopreserved hiPSCs using a custom-made cryo Raman microscope, flow cytometry, and performance indices to assess viability. Raman spectroscopy indicated the disappearance of mitochondrial cytochrome signals after thawing. A reduction in the mitochondrial membrane potential was detected using flow cytometry. The performance indices indicated a decrease in attachment efficiency with an increase in the number of temperature cycles. This decrease was observed in the temperature cycle range above the glass transition temperature of the cryoprotectant. Raman observations captured an increase in the signal intensity of intracellular dimethyl sulfoxide (DMSO) during temperature cycles. Based on these results, we proposed a schematic illustration for cellular responses to temperature fluctuations, suggesting that temperature fluctuations above the glass-transition temperature trigger the movement of DMSO, leading to cytochrome c oxidation, mitochondrial damage, and caspase-mediated cell death. This enhances our understanding of the key events during cryopreservation and informs the development of quality control strategies for hiPSC storage and transport.
Evolutionarily conserved enhancer-associated features within the MYEOV locus suggest a regulatory role for this non-coding DNA region in cancer
Authors: Davidson Brigid S. A. , Arcila-Galvis Juliana Estefania , Trevisan-Herraz Marco , Mikulasova Aneta , Brackley Chris A. , Russell Lisa J. , Rico Daniel
Published: July 2024

The myeloma overexpressed gene (MYEOV) has been proposed to be a proto-oncogene due to high RNA transcript levels found in multiple cancers, including myeloma, breast, lung, pancreas and esophageal cancer. The presence of an open reading frame (ORF) in humans and other primates suggests protein-coding potential. Yet, we still lack evidence of a functional MYEOV protein. It remains undetermined how MYEOV overexpression affects cancerous tissues. In this work, we show that MYEOV has likely originated and may still function as an enhancer, regulating CCND1 and LTO1. Firstly, MYEOV 3′ enhancer activity was confirmed in humans using publicly available ATAC-STARR-seq data, performed on B-cell-derived GM12878 cells. We detected enhancer histone marks H3K4me1 and H3K27ac overlapping MYEOV in multiple healthy human tissues, which include B cells, liver and lung tissue. The analysis of 3D genome datasets revealed chromatin interactions between a MYEOV-3′-putative enhancer and the proto-oncogene CCND1. BLAST searches and multi-sequence alignment results showed that DNA sequence from this human enhancer element is conserved from the amphibians/amniotes divergence, with a 273 bp conserved region also found in all mammals, and even in chickens, where it is consistently located near the corresponding CCND1 orthologues. Furthermore, we observed conservation of an active enhancer state in the MYEOV orthologues of four non-human primates, dogs, rats, and mice. When studying this homologous region in mice, where the ORF of MYEOV is absent, we not only observed an enhancer chromatin state but also found interactions between the mouse enhancer homolog and Ccnd1 using 3D-genome interaction data. This is similar to the interaction observed in humans and, interestingly, coincides with CTCF binding sites in both species. Taken together, this suggests that MYEOV is a primate-specific gene with a de novo ORF that originated at an evolutionarily older enhancer region. This deeply conserved putative enhancer element could regulate CCND1 in both humans and mice, opening the possibility of studying MYEOV regulatory functions in cancer using non-primate animal models.
Genome-wide sRNA and mRNA transcriptomic profiling insights into carbapenem-resistant Acinetobacter baumannii
Authors: Wei Yong , Xin Xuli , Zhang Jiachun , Liao Qifeng , Rong Yan , Zhong Ying , Zhao Meiying , Ma Jianping , He Song
Published: July 2024

Introduction

Acinetobacter baumannii (AB) is rising as a human pathogen of critical priority worldwide as it is the leading cause of opportunistic infections in healthcare settings and carbapenem-resistant AB is listed as a “super bacterium” or “priority pathogen for drug resistance” by the World Health Organization.

Methods

Clinical isolates of A. baumannii were collected and tested for antimicrobial susceptibility. Among them, carbapenem-resistant and carbapenem-sensitive A. baumannii were subjected to prokaryotic transcriptome sequencing. The change of sRNA and mRNA expression was analyzed by bioinformatics and validated by quantitative reverse transcription-PCR.

Results

A total of 687 clinical isolates were collected, of which 336 strains of A. baumannii were resistant to carbapenem. Five hundred and six differentially expressed genes and nineteen differentially expressed sRNA candidates were discovered through transcriptomic profile analysis between carbapenem-resistant isolates and carbapenem-sensitive isolates. Possible binding sites were predicted through software for sRNA21 and adeK, sRNA27 and pgaC, sRNA29 and adeB, sRNA36 and katG, indicating a possible targeting relationship. A negative correlation was shown between sRNA21 and adeK (r = -0.581, P = 0.007), sRNA27 and pgaC (r = -0.612, P = 0.004), sRNA29 and adeB (r = -0.516, P = 0.020).

Discussion

This study preliminarily screened differentially expressed mRNA and sRNA in carbapenem-resistant A. baumannii, and explored possible targeting relationships, which will help further reveal the resistance mechanism and provide a theoretical basis for the development of drugs targeting sRNA for the prevention and treatment of carbapenem-resistant A. baumannii infection.
Cross-cultural comparative analysis of student motivation and autonomy in learning: perspectives from Hong Kong and the United Kingdom
Authors: Lo Noble Po-Kan
Published: July 2024

Introduction

This research project examines student perspectives on independent learning in the United Kingdom and Hong Kong. Independent learning describes learning undertaken by students outside of standard institutional learning environments. Prior research has suggested that motivations to undertake independent learning and the strategies involved may differ across cultural contexts, institutions, and individual learners.

Methods

This research employs primary qualitative research consisting of interviews with 16 students in Business Studies (eight British and eight Chinese). The study takes a social constructionist approach to better establish the ways in which culture may serve as a mediator for motivation to learn independently and the strategies pursued to this end.

Results

The study’s findings note key differences in the motivations to complete independent learning across either cohort, as well as distinct conceptualizations of what strategies and practices facilitate effective independent learning.

Discussion

This research highlights significant cultural differences in the motivations, strategies, and skills related to independent learning between students in the United Kingdom and Hong Kong. It also notes the potential for socioeconomic factors, institutional structures, and assessment methods, alongside culture, to contribute to these differences.
Screening NLRP3 drug candidates in clinical development: lessons from existing and emerging technologies
Authors: Tengesdal Isak W. , Banks Migachelle , Dinarello Charles A. , Marchetti Carlo
Published: July 2024

Decades of evidence positioned IL-1β as a master regulatory cytokine in acute and chronic inflammatory diseases. Approved biologics aimed at inhibiting IL-1 signaling have shown efficacy but variable safety. More recently, targeting NLRP3 activation, an upstream mediator of IL-1β, has garnered the most attention. Aberrant NLRP3 activation has been demonstrated to participate in the progression of several pathological conditions from neurogenerative diseases to cardio-metabolic syndromes and cancer. Pharmacological and genetic strategies aimed to limit NLRP3 function have proven effective in many preclinical models of diseases. These evidences have lead to a significant effort in the generation and clinical testing of small orally active molecules that can target NLRP3. In this report, we discuss different properties of these molecules with translational potential and describe the technologies currently available to screen NLRP3 targeting molecules highlighting advantages and limitations of each method.
Prospects for 3D-printing of clear aligners—a narrative review
Authors: Niu Chenyang , Li Dongwen , Zhang Yujia , Wang Yunkai , Ning Shangbo , Zhao Gang , Ye Zhihui , Kong Yu , Yang Donghong
Published: July 2024

Clear aligner therapy is a rapidly developing orthodontic treatment. 3D-printing technology, which enables the creation of complex geometric structures with high precision, has been used in dentistry. This article aims to summarize the various aspects of 3D-printing clear aligners and give an outlook on their future development. The traditional thermoforming technology is introduced and the principle and application of 3D-printed clear aligners and materials are introduced, as well as the application prospects of 3D-printed clear aligners. According to PRISMA statement, the relevant literature of 3D-printing clear aligner was searched in PubMed, Web of Science, Embase and other databases. We searched the related words in the MESH database and then carried out advanced searches. We read systematic review and conference papers to find the articles related to the subject and manually added and excluded articles by reading the title and abstract. The production of clear aligners combines computer-aided 3D analysis, personalized design and digital molding technology. The thickness and edges of the 3D-printed clear aligner can be digitally controlled, which allows appliance more efficiently fitted. Presently, the array of clear resins suitable for 3D-printing include photo polymeric clear methacrylate-based resin (Dental LT) (Form Labs, Somerville, Mass), aliphatic vinyl ester-polyurethane polymer (Tera Harz TC-85) (Graphy, Seoul, South Korea). They all have good biocompatibility. But no such material is currently approved on the market. Developing biocompatible resins and further improving the material’s mechanical properties will be critical for the combination of 3D-printing and clear aligners. However, the literature on 3D-printed clear aligners is limited and lacks clinical application. Further in vivo and in vitro tests, as well as additional exploration in conjunction with corresponding cytological tests, are required for the research on available materials and machinery for 3D-printing clear aligners.
The nucleus accumbens shell: a neural hub at the interface of homeostatic and hedonic feeding
Authors: Marinescu Alina-Măriuca , Labouesse Marie A.
Published: July 2024

Feeding behavior is a complex physiological process regulated by the interplay between homeostatic and hedonic feeding circuits. Among the neural structures involved, the nucleus accumbens (NAc) has emerged as a pivotal region at the interface of these two circuits. The NAc comprises distinct subregions and in this review, we focus mainly on the NAc shell (NAcSh). Homeostatic feeding circuits, primarily found in the hypothalamus, ensure the organism’s balance in energy and nutrient requirements. These circuits monitor peripheral signals, such as insulin, leptin, and ghrelin, and modulate satiety and hunger states. The NAcSh receives input from these homeostatic circuits, integrating information regarding the organism’s metabolic needs. Conversely, so-called hedonic feeding circuits involve all other non-hunger and -satiety processes, i.e., the sensory information, associative learning, reward, motivation and pleasure associated with food consumption. The NAcSh is interconnected with hedonics-related structures like the ventral tegmental area and prefrontal cortex and plays a key role in encoding hedonic information related to palatable food seeking or consumption. In sum, the NAcSh acts as a crucial hub in feeding behavior, integrating signals from both homeostatic and hedonic circuits, to facilitate behavioral output via its downstream projections. Moreover, the NAcSh’s involvement extends beyond simple integration, as it directly impacts actions related to food consumption. In this review, we first focus on delineating the inputs targeting the NAcSh; we then present NAcSh output projections to downstream structures. Finally we discuss how the NAcSh regulates feeding behavior and can be seen as a neural hub integrating homeostatic and hedonic feeding signals, via a functionally diverse set of projection neuron subpopulations.
Multiple aspects of amyloid dynamics in vivo integrate to establish prion variant dominance in yeast
Authors: Norton Jennifer , Seah Nicole , Santiago Fabian , Sindi Suzanne S. , Serio Tricia R.
Published: July 2024

Prion variants are self-perpetuating conformers of a single protein that assemble into amyloid fibers and confer unique phenotypic states. Multiple prion variants can arise, particularly in response to changing environments, and interact within an organism. These interactions are often competitive, with one variant establishing phenotypic dominance over the others. This dominance has been linked to the competition for non-prion state protein, which must be converted to the prion state via a nucleated polymerization mechanism. However, the intrinsic rates of conversion, determined by the conformation of the variant, cannot explain prion variant dominance, suggesting a more complex interaction. Using the yeast prion system [PSI+], we have determined the mechanism of dominance of the [PSI+]Strong variant over the [PSI+]Weak variant in vivo. When mixed by mating, phenotypic dominance is established in zygotes, but the two variants persist and co-exist in the lineage descended from this cell. [PSI+]Strong propagons, the heritable unit, are amplified at the expense of [PSI+]Weak propagons, through the efficient conversion of soluble Sup35 protein, as revealed by fluorescence photobleaching experiments employing variant-specific mutants of Sup35. This competition, however, is highly sensitive to the fragmentation of [PSI+]Strong amyloid fibers, with even transient inhibition of the fragmentation catalyst Hsp104 promoting amplification of [PSI+]Weak propagons. Reducing the number of [PSI+]Strong propagons prior to mating, similarly promotes [PSI+]Weak amplification and conversion of soluble Sup35, indicating that template number and conversion efficiency combine to determine dominance. Thus, prion variant dominance is not an absolute hierarchy but rather an outcome arising from the dynamic interplay between unique protein conformations and their interactions with distinct cellular proteostatic niches.
Research advances in the therapy of metabolic syndrome
Authors: Lin Zitian , Sun Luning
Published: July 2024

Metabolic syndrome refers to the pathological state of metabolic disorder of protein, fat, carbohydrate, and other substances in the human body. It is a syndrome composed of a group of complex metabolic disorders, whose pathogenesis includes multiple genetic and acquired entities falling under the category of insulin resistance and chronic low-grade inflammationand. It is a risk factor for increased prevalence and mortality from diabetes and cardiovascular disease. Cardiovascular diseases are the predominant cause of morbidity and mortality globally, thus it is imperative to investigate the impact of metabolic syndrome on alleviating this substantial disease burden. Despite the increasing number of scientists dedicating themselves to researching metabolic syndrome in recent decades, numerous aspects of this condition remain incompletely understood, leaving many questions unanswered. In this review, we present an epidemiological analysis of MetS, explore both traditional and novel pathogenesis, examine the pathophysiological repercussions of metabolic syndrome, summarize research advances, and elucidate the mechanisms underlying corresponding treatment approaches.