bluuebunny/crossref_metadata_2025 huggingface dataset:
Adjuvant Treatment for Breast Cancer Patients Using Individualized Neoantigen Peptide Vaccination—A Retrospective Observation
Authors: Zelba Henning , McQueeney Alex , Rabsteyn Armin , Bartsch Oliver , Kyzirakos Christina , Kayser Simone , Harter Johannes , Latzer Pauline , Hadaschik Dirk , Battke Florian , Hartkopf Andreas D. , Biskup Saskia
Published: November 2022

Breast cancer is a tumor entity that is one of the leading causes of mortality among women worldwide. Although numerous treatment options are available, current explorations of personalized vaccines have shown potential as promising new treatment options to prevent the recurrence of cancer. Here we present a small proof of concept study using a prophylactic peptide vaccination approach in four female breast cancer patients who achieved remission after standard treatment. The patients were initially analyzed for somatic tumor mutations and then treated with personalized neoantigen-derived peptide vaccines. These vaccines consisted of HLA class I and class II peptides and were administered intracutaneously followed by subcutaneous application of sargramostim and/or topical imiquimod as an immunological adjuvant. After an initial priming phase of four vaccinations within two weeks, patients received monthly boosting/maintenance vaccinations. Chemotherapy or checkpoint inhibition was not performed during vaccination. One patient received hormone therapy. The vaccines were well tolerated with no serious adverse events. All patients displayed vaccine-induced CD4+ and/or CD8+ T-cell responses against various neoantigens. Furthermore, all patients remained tumor-free and had persistent T-cell responses, even several months after the last vaccination, suggesting the potential of peptide vaccines as an immunosurveillance and long term prophylaxis option.
Adsorption of Methylene Blue by Coal-Based Activated Carbon in High-Salt Wastewater
Authors: Wang Jinlong , Ma Jingqian , Sun Yongjun
Published: November 2022

High-salt printing and dyeing wastewater is a difficult industrial wastewater to treat. Coal-based activated carbon (CBAC) can be used as an adsorbent to treat high-salt printing and dyeing wastewater and realize the resource utilization of CBAC. In this study, simulated wastewater that contained methylene blue (MB) was used as the research object, and CBAC was used as the adsorbent. The effects of CBAC dosage, NaCl concentration, coexisting ions, adsorption time, MB concentration, humic acid concentration, and solution pH on the adsorption performance of CBAC with MB were discussed. The results showed that when the CBAC dosage was 0.6 g/L, the solution pH was greater than 6, the adsorption time was 8 h, the adsorption temperature was 308 K, and the MB concentration was 10 mg/L. Thus, the maximum adsorption capacity of CBAC with MB was obtained. The maximum adsorption capacity and removal rate were 15.5 mg/L and 90%, respectively. High-salt wastewater can inhibit the adsorption of methylene blue by coal-based activated carbon. In addition, 20 g/L of NaCl reduced the adsorption capacity of coal-based activated carbon by 1.8 mg/g. Compared to the other coexisting ions, the influence of the presence of Cu2+ and Fe3+ on the removal of methylene blue was greater. However, when Cu2+, Fe3+ and high-salt wastewater coexist, the inhibition effect decreases.
Characteristics of Evapotranspiration and Crop Coefficient Correction at a Permafrost Swamp Meadow in Dongkemadi Watershed, the Source of Yangtze River in Interior Qinghai–Tibet Plateau
Authors: Guo Haonan , Wang Shaoyong , He Xiaobo , Ding Yongjian , Fan Yawei , Fu Hui , Hong Xiaofeng
Published: November 2022

The Qinghai–Tibet Plateau (QTP), known as the Earth’s third pole, is highly sensitive to climate change. Various environmental degradation has occurred due to the effects of climate warming such as the degradation of permafrost and the thickening of active layers. Evapotranspiration, as a key element of hydrothermal coupling, has become a key factor of the plateau environment for deciphering deterioration, and the FAO P-M model has a good physical foundation and simple model data requirements as a primary tool to study the plateau evapotranspiration. There has been a large research base, but the estimation of evapotranspiration in alpine regions is still subject to many uncertainties. This is reflected in the fact that the classification of underlying surface types has not been sufficiently detailed and the evapotranspiration characteristics of some special underlying surface types are still unclear. Therefore, in this work, we modified the FAO P-M coefficients based on the characteristics of actual evapotranspiration measured by the Eddy covariance system and the key influencing factors to better simulate the actual evapotranspiration in alpine swamp meadow. The results were as follows: (1) Both ETa measured by the Eddy covariance system and ET0 calculated by FAO P-M showed the same trend at the daily and annual scales and hysteresis was confirmed to exist, so the error caused by hysteresis should be considered in further research. (2) The annual ETa was 566.97 mm and annual ETa/P was 0.76, and about 11.19% of ETa occurred during the night. The ETa was 2.15 during the non-growing seasons, implying that a large amount of soil water was released into the air by evapotranspiration. (3) The evapotranspiration characteristics of alpine swamp meadow are formed under the following conditions: control of net radiation (Rn) affected by VPD during the growing season and affected by soil temperature and humidity during the non-growing season. Precipitation and soil water content are no longer the main controlling factors of evapotranspiration during the growing season at the alpine swamp meadow as the volume soil water content tends to saturate. (4) The basic corrected Kc was 1.14 during the initial and mid-growing season, 1.05 during the subsequent growing season, and 0–0.25 during the non-growing season, and the correction factor process can also provide ideas for correcting the Kc of other vegetation.
Water Context in Latin America and the Caribbean: Distribution, Regulations and Prospects for Water Reuse and Reclamation
Authors: Rodríguez Carolina , García Bárbara , Pinto Caterin , Sánchez Rafael , Serrano Jennyfer , Leiva Eduardo
Published: November 2022

Water scarcity is a problem of global relevance that is affecting more and more people in the world. Latin America and the Caribbean (LAC) have around 35% of the world’s renewable water resources. However, the management of water resources and inequality in access to water has made water scarcity a problem of growing interest in the region. The reuse of water could be an efficient measure to reduce the demand for water resources in the area. In particular, the reuse of greywater is a simple and decentralized method of water reuse, which would mitigate the impact of the lack of water in isolated or difficult-to-access areas. Using the Aquastat database, water consumption in the world and water availability in LAC were studied. In addition, the regulatory framework for water in LAC countries was studied, with an emphasis on water reuse and greywater legislation. Agriculture is one of the most demanding of water in the world, particularly, in LAC, which demands around 70% of renewable water resources. Furthermore, in LAC, the availability of drinking water in rural areas is lacking, with seven countries having less than 80% access to healthy drinking water. The water regulation in LAC is quite heterogeneous. The most general regulation around water is found in the political constitutions of each country. Some constitutions explicitly indicate access to water as a human right, while other constitutions do not include information in this regard. Although some countries have specific regulations on the reuse of wastewater, there is a general lack of regulations related to the reuse of greywater. In most cases, the term “greywater” is not even defined in the general water and wastewater laws. As of the date of this article, only Chile, Peru, and Brazil have bills to regulate the reuse of greywater, of which only the Chilean is approved. The reuse of greywater could help reduce water demand for non-drinking uses. However, the implementation of greywater treatment systems represents a cost that is difficult to cover, especially in the poorest countries of the region. Countries must improve their public policies to improve the management, use and reuse of water to mitigate water scarcity that severely affects human consumption in the region. The relevance of this study lies in providing a general framework of the water situation in LAC for studies and public policies focused on promoting water reuse as a measure to mitigate water scarcity.
Ensuring Sustainability of Territorial Housing Markets in a Turbulent Economy (on the Example of the Penza Region)
Authors:   Moscow State University of Civil Engineering (MGSU) National Research University, Kulakov Kirill Yu. ,   Regional Association of appraisers,   Association of Financial and Economic Forensic Experts,   National Association of SRO Appraisers, Popova Inna V. ,   Penza State University of Architecture and Construction.
Published: November 2022

The article provides a comprehensive structural analysis of ensuring stability for the territorial housing market in a turbulent economy on the example of the Penza region. The study was carried out in the following fields: structure of developers, volumes and dynamics of construction, the price range of new buildings. In addition, financial express analysis of the main developers in the region was carried out in order to identify their financial stability over the forecast horizon in the face of economic uncertainty. As a separate segment of the research, it is accepted to study dynamics of the main parameters of the mortgage territorial market as the main regulator of the housing market development. Formulated conclusions provide an opportunity to the subjects of the territorial housing market to form innovative individual corporate and government strategies of sustainable development for the short term in a turbulent economy.
Modeling Depopulation Trends in the Community of Countries with Different Economic Development Levels
Authors:   Administration of NRC Kurchatov Institute, Zhulego Vladimir G. ,   Association for the Promotion of the Development of Scientific Expertise and Consulting ",   ANEK", Balyakin Artem A. ,   NRC Kurchatov Institute.
Published: November 2022

In this paper, an attempt is made to develop a mathematical model of population growth, based on socio-economic factors of the development of the countries’ community, as well as population migration. The author presents intermediate results of his review where he studies economic community, characterized by a very uneven development of regions. Mathematical model is proposed in which a conditional "center" and "periphery" ("global city" and "world village") are distinguished. From the analysis of the existing socio-economic conditions of development it follows that "periphery" traditionally acts as a demographic donor for the "center". Examples of such systems include, in particular, relations of the EU-Baltic republics, the EU-Ukraine, and Russia–EAEU countries. As an explanatory principle, it is proposed to use the concept of "institutional trap". From the mathematical model point of view, this means rigidly fixed coefficients of connection between the system elements implementing one-way connection (toward the "center"). Possible mechanisms, influencing the dynamics of the system through adopting appropriate managerial decisions, are discussed. Obtained results prove the importance of adequate mathematical models for optimizing the strategic management of society.
Evolution of Scientific Views on the Problem of Forming Business Value
Authors:   Financial University under the Government of the Russian Federation., Erofeeva Tat'yana A.
Published: November 2022

The article analyzes scientific views of different schools and directions of economic thought on the business value formation. In the study, the author identifies and analyzes the main approaches of theoretical and economic research to studying the problem of the business value formation: cost and behaviour. The author comes to believe that scientific views on the problem of value formation were evolving along the line of "cost approach → behavioral approach". The process of forming the value of business is a system of economic interactions. Any system of economic interactions of various subjects should be institutionalized. Certain formal and informal norms and rules of conduct organize and coordinate the process of business value formation.
Scenario Analysis of the Fuel Company Competitiveness in the World Market of Tolerant Nuclear Fuel for NPPs
Authors:   National Research Nuclear University MEPhI., Semenov Evgenii V. , Kharitonov Vladimir V. ,   National Research Nuclear University MEPhI.
Published: November 2022

The article analyses the market of goods and services at the initial stage of nuclear fuel cycle. Particular attention is paid to nuclear fuel fabrication and the impact of new promising types of fuel (including tolerant) on domestic companies’ market positions. Based on scenario analysis, the authors show the possibility to partially offset export earnings in case of possible loss of the fabrication market share due to increasing sales in other key stages of the nuclear fuel cycle — uranium conversion and enrichment.
Epic Fail of BigTech Digital Transformation. Where is the Key to Level Up? [Epic Fail of Digital Transformation of Transnational Corporations. Where is the Key to a Level up Management?]
Authors:   RT-NI, ANO., Kutin Vladimir N. , Khokhlova Marina N. ,   Intersectoral Union "Neftegazinvest".
Published: November 2022

World trend of the XXI century — Industry 4.0 and digital platforms. In 2014, General Electric (GE) partnered with Big Tech giants — AT&T, Cisco, IBM and Intel — to take control of the global manufacturing industry created the Industrial Internet Contributors Association (Industry IoT Consortium IIC). By 2021, the IIC included Microsoft, Hewlett-Packard, Accenture, Huawei, Bosch, EMC, SAP, Siemens, SAS and others. GE together with BigTech created the industrial cloud platform Predix, declaring it to be practically an “operating system” for factories, analogous to Android or iOS in the world of machines, the language of the industrial Internet. However, in 2020 GE and Predix suffered a devastating fiasco. The article provides an analysis of the root causes and problems, and formulates the requirements for digital platforms of industrial software. The author describes alternative solutions and new principles for implementing digital transformation of Industry 4.0 based on the closing technologies of digital genesis, graph-centric platforms, tools, models and systems of collective conscious scientifically based balanced management (industrial, corporate, social, state). Closing technologies offered by Russia have got an enormous social and political resource.
Resilience of tne Will
Authors:   MGIMO University, Ageev Aleksandr I. ,   Institute for Economic Strategies
Published: November 2022

Opening address of the Editor-in-chief
Poverty, Inequality, National Wealth: Empirical Analysis and Policy Implications
Authors:   Institute of Economy of the Russian Academy of Sciences, Sukharev Oleg S.
Published: November 2022

The article is devoted to the study of poverty and inequality in the economic growth of the most developed countries, with a general focus on the formation of social policy consistent with the growth policy. The purpose of the study is to conduct a macroeconomic analysis of poverty, inequality and wealth in the G7 countries, China and Russia, with the ensuing substantiation of a social development strategy for the Russian economy. The methodology is made up of empirical analysis, as well as regression modeling, which make it possible to identify in a comparative way the connectivity of the dynamics of relevant indicators of social development — the level of national poverty and wealth, the Gini coefficient and general inequality, growth rate, human development index. The result of the study is a precisely confirmed empirical relationship between the level of poverty and inequality for the countries considered, that is, a high value of one parameter corresponds to a high value of another. Consequently, poverty reduction may imply a reduction in inequality, and not only relative, but also absolute. In addition, it was found that for developed countries, high levels of poverty and inequality mean low values of the human development index. Social policy aimed at human development requires that its instruments be harmonized, including the necessary alignment with the current macroeconomic policies to stimulate growth. The magnitude of national wealth does not guarantee high growth rates, as well as low levels of inequality and poverty. A high level of inequality can accompany economic growth, having a positive effect on the growth rate, as for the Russian economy. In this regard, the current policy needs a reasonable selection of measures to stimulate growth and, at the same time, measures to reduce inequality, which can and should not be limited only to tax changes that require special confirmation of influence, but to institutional changes that regulate the creation and appropriation of income.
Successful treatment of mesenteric thrombosis developed in a patient with hypernephroma after nephrectomy with inferior vena cava thrombectomy
Authors:   FSBEI HE Bashkir State Medical University of the Ministry of Health of the Russian Federation, Galimov O.V. , Khanov V.O. ,   FSBEI HE Bashkir State Medical University of the Ministry of Health of the Russian Federation, Ibragimov T.R. ,   FSBEI HE Bashkir State Medical University of the Ministry of Health of the Russian Federation
Published: November 2022

The article presents a clinical case of successful treatment of small intestine gangrene due to mesenteric thrombosis that developed in a patient with hypernephroma after nephrectomy with inferior vena cava thrombectomy.
Stripping vs endovenous thermal ablation in varicose veins: 5 year clinical and hemodynamic results of a randomized study
Authors:   Federal State Educational Institution of Higher Education «Ural State Medical University» of the Ministry of Education of the Russian Federation, Ekaterinburg, Russia, Burleva E. P. , Tyurin S. A. ,   Olmed Medical Center, Ekaterinburg, Russia, Peshkov A. V. ,   Olmed Medical Center, Ekaterinburg, Russia
Published: November 2022

The aim of the study was to analyze the five-year clinical and hemodynamic results after minimally invasive phlebectomy and endovenous thermal ablation in patients with СVD class C2. The study included three groups of patients that differed in the technique of elimination of vertical GSV reflux within the thigh. The patients were stratified according to a certain hemodynamic profile: 1st group (stripping) included 63 patients; 2nd group (EVLC) — 61 patients; 3rd group (RFA) — 61 patients. A number of ultrasound hemodynamic parameters was studied in each group. The comparative study of the course of the late postoperative period was carried out; it included clinical examination, calculation of the total VCSS score, and ultrasound of the veins of lower extremities. As a result, it was found that in certain VV patients, after the removal of the GSV trunk within the thigh, a significant restructuring of the venous bed was observed in 1 year. It developed according to various scenarios. In the 1st group, medial and lateral overflows appeared on the thigh with drainage into the residual trunk; in the 2nd and 3rd group it was not observed, but the perforating reflux to the residual GSV trunk was gradually increasing. The restructuring of the venous bed caused valvular insufficiency of the trunk in 29 % of patients in the 1st group, 17.2 % in the 2nd group, and in 19.3 % of patients in the 3rd group by the 5th year of follow-up. As the pathological process was developing, the diameter of the GSV trunk on the shin was progressively increasing, and the summarized diameter of the PV of the lower leg was also increasing. By the 5th year of follow-up, perforant insufficiency was registered in 32.2 % of patients in the 1st group, 37.9 % in the 2nd group, and in 38.7 % of patients in the 3rd group. The changes detected during ultrasound had no significant effect on the clinic. The overall VCSS score decreased by the 1st year of follow-up after all interventions, and then remained consistently low in all groups over the years.
Productivity of laying hens of the cross Czech Dominant when using the biologically active additive Api-Spira
Authors:   Federal State Budgetary Educational Institution of Higher Education “Belgorod State Agrarian University named after V. Ya. Gorin”, Russia, Belgorod region, Belgorod area, Maysky, Chekhunova G. S. , Kornienko P. P. ,   Federal State Budgetary Educational Institution of Higher Education “Belgorod State Agrarian University named after V. Ya. Gorin”, Russia, Belgorod region, Belgorod area, Maysky
Published: November 2022

Currently, one of the factors of increasing the productivity of poultry is the introduction of biologically active additives into the feeding diet, which in turn have a diverse composition and their main role is not only to increase production, but also to improve the quality of producing products at low production costs. One of the well-proven is the biologically active additive Api-Spira. It has been studied with a positive effect on broilers, as well as on some farm animals. It contains only natural substances. The purpose of the research was to study the productivity of laying hens of the cross Czech Dominant when using the biologically active additive Api-Spira. The economic effi ciency of using the biologically active additive Api-Spira at a dose of 1,28 g per laying hen (the 2nd experimental group) was higher than in the 1st control group, where the additive was not used. Thus, the level of profi tability of egg production in the 2nd experimental group was 21,5 %, and in the 3rd and 4th experimental groups it was 16,8 %, which exceeded the indicator of the 1st control group by 5,7 and 1,0 abs.%, respectively. Thus, the study of the productivity of laying hens of the cross Czech Dominant when drinking the biologically active additive Api-Spira showed the eff ectiveness of its use. In order to improve the productivity of laying hens of egg crosses, we recommend the use of the biologically active additive Api-Spira with the main diet of 1,28 g per laying hen for 180 days according to the scheme: a month of drinking, a month break.
Feeding of replacement heifers during the rearing in the preweaning period
Authors:   Federal State Budgetary Educational Institution of Higher Education “Kurgan State Agricultural Academy named after T. S. Maltsev”, Russia, Kurgan region, Lesnikovo, Karmatskikh Yu. A. , Kostomakhin N. M. ,   Federal State Budgetary Educational Institution of Higher Education “Russian State Agrarian University – Moscow Timiryazev Agricultural Academy”, Russia, Moscow
Published: November 2022

A rational system of rearing young animals taking into account the biological characteristics of animals should contribute to normal growth, development, formation of high productivity and a strong constitution, prolonging the terms of economic use of livestock. The purpose of the research was to analyze the rearing of replacement heifers during the preweaning period when using bentonite clay as a mineral supplement in diets. Three groups of heifers were formed to conduct research. Bentonite was introduced into the diet of the heifers of the 1st experimental group at the rate of 1 % of the compound feed composition, the heifers of the 2nd experimental group were input with 2 % bentonite into the compound feed, and the heifers of the control group did not receive bentonite. In the course of research an analysis of the infl uence of bentonite on the growth and development of heifers of Black-and-White breed up to 6 months of age in the winter period of their rearing was given. The feeding diets of heifers from birth to 6 months of age monthly were presented in the paper. It was found as a result that bentonite introduced into the diet of animals of experimental groups allowed to increase the digestibility and accessibility of nutrients in the diets. Thus, the coeffi cient of digestibility of dry matter in the heifers of the control group was lower compared with the herdmates of the 2nd experimental group by 2,02 abs.%. The organic matter of the animals of the control group digested less compared to the 1st experimental group by 0,29 abs.%, and from the 2nd group by 2,17 abs.% The coeffi cient of digestibility of crude protein in the 1st experimental group was by 0,65 abs.% less, and in the 2nd experimental group 1,63 abs.% (p < 0,05) more than in the control.
Procedimiento para el pronóstico de indicadores económicos mediante técnicas econométricas en Alastor, Cuba
Authors: Laffita Riverón Anaís , Riverón Hernández Matilde Irene , Ibarra Miranda Daideé Caridad , Carmenate García Héctor José
Published: November 2022

La planificación es imprescindible para el logro de mayores niveles de eficiencia, eficacia y efectividad en el desempeño de cualquier organización. Prestar atención a este proceso, de manera especial en el área económica, es estratégico. En ello pueden tener un papel fundamental los métodos cuantitativos de pronóstico. La investigación tuvo como objetivo el desarrollar un procedimiento para el pronóstico de indicadores económicos basado en la integración de herramientas administrativas y técnicas econométricas como el análisis de regresión, el alisamiento exponencial y la Metodología Box-Jenkins para favorecer la planificación empresarial de indicadores económicos. El procedimiento estructurado en cuatro fases y trece pasos se aplicó para el pronóstico de las utilidades en Alastor, empresa de mantenimiento de sistemas de refrigeración y calefacción. Como resultado se obtiene que el mejor modelo para pronosticar las utilidades es el obtenido a través del alisamiento exponencial Holt Winters con estacionalidad modelo aditivo. Ello permitió elaborar el plan económico para el año 2021.
Agencia de Viajes Bucéano y su aporte al turismo cubano
Authors: Aguiar Hernández Lázara Yadiris , Reyes Rodriguez Neysa , Mesa Reyes Adalys María , Rodríguez Pérez Gilbeysis , Martell Márquez Melissa Marla , Martínez Fernández Mariela
Published: November 2022

Cuba posee una belleza submarina inigualable; la flora y fauna que albergan sus profundidades son reconocidas internacionalmente y constituyen un gran atractivo para muchos de los visitantes de la isla que viajan motivados, principalmente, por el buceo. Sin embargo, a pesar de las grandes potencialidades que existen a lo largo y ancho del país, no se ha creado ninguna agencia de viajes especializada propiamente en esta actividad. Es por tal razón que la presente investigación persiguió elaborar el proyecto de diseño de una agencia de viajes especializada en buceo con el nombre “Bucéano”. Con este fin se emplearon, como parte de una metodología mixta desde un enfoque cualitativo y a su vez cuantitativo, métodos como el análisis-síntesis, inducción-deducción, revisión documental, tormenta de ideas, así como otras herramientas que permitieron desarrollar la investigación en nueve consecuentes etapas. En principio se realizó una investigación turística general, y se identificó y caracterizó el segmento de demanda objetivo. Posteriormente se diseñaron, de manera preliminar, los productos y servicios de la agencia, y se identificaron sus canales de distribución. Por su parte, se identificaron los recursos humanos, técnicos, materiales y financieros necesarios, así como los trámites para la apertura de la agencia. Se realizaron estudios de localización y entorno, y económico-financiero. Por último, se simuló el funcionamiento inicial de la agencia desde el punto de vista del ciclo de dirección. Todo ello permitió conformar el proyecto de diseño de la agencia de viajes especializada en buceo “Bucéano”.
Les arrêts Battisti devant la Cour suprême brésilienne : la portée du contrôle des juridictions nationales sur les actes de la politique étrangère
Authors: Damásio borges Daniel
Published: November 2022

The extradition of the Italian national Cesare Battisti raised in Brazil a very controversial political and legal debate. Two judgements of the Brazilian Supreme Court have dealt with Italy’s request for extradition. In a first judgement, the Supreme Court authorized the extradition of Battisti on the grounds that he is not a political refugee and that he has not been sentenced for a political crime. In the second judgement, the Supreme Court acknowledged to the President of the Republic the discretion to extradite or not Battisti. According to the Brazilian high court, the decisions of the President of the Republic on external sovereignty lie beyond judicial cognizance. The same legal reasoning was followed when the judge of the Supreme Court, Luiz Fux, decided that the President of the Republic could change his opinion on the extradition of the Italian national. This argument seems to us contrary to the rules of the Brazilian Constitution governing foreign policy.
La chapelle du prieuré de la Colombe à Brissac-Quincé (Maine-et-Loire) : une maladrerie médiévale ?
Authors: Asseray Nicolas
Published: November 2022

Lost in the shadow of the Château de Brissac, the chapel of the priory of La Colombe, situated north of the town, has rarely been considered in studies of Brissacois patrimony. Yet the building has a rich history, with several building campaigns in the Middle Ages. A study of the construction and a close analysis of the sources bearing on the site have clarified the complex architectural history of the building, composed of a large hall under a paneled ceiling and a small vaulted building to the east, considered by historians to be the nave and choir of a chapel. The way in which the two spaces are articulated raises questions about their functional interpretation. The two spaces communicate through a large doorway framed by drip-edge molding and closed by a double door, thus isolating the two parts of the edifice. Our research has led us to propose a new hypothesis concerning the nature of the ensemble and its disposition, which call to mind the layout of several medieval chaplaincies, composed of a large hall for the sick and an adjoining chapel.
Les relations entre les artistes de Jean de Berry et les tuiliers mudejars du royaume d’Aragon
Authors: Rapin Thomas
Published: November 2022

Jean de France, Herzog von Berry (1340-1416) war ein aufgeschlossener und vielseitiger Mäzen. Wie die aragonischen Könige und Fürsten fand er Geschmack an „ maurischen“ und „ sarazenischen“ Ornamenten und beschäftigte daher Mudéjar-Künstler, die mit ihrem Talent den Glanz der muslimischen Kunst im Spanien der Reconquista fortleben ließen. Im Frühjahr 1382 erhielt er vom Herzog von Gerona, einem Verwandten, die Erlaubnis, drei maurische Ziegelbrenner aus der Gegend von Valence kommen zu lassen, die er dann auf seinen Baustellen von Bourges, Mehun-sur-Yèvre und Poitiers beschäftigte. Zum ersten Mal wurde in Frankreich ein Programm verwirklicht, das die Prunkräume des Herzogs ausschließlich mit wappengeschmückten Fayance-Fliesen ausstattete.
Miscellaneous Typifications and New Synonyms Toward a Revision of Mandevilla (Apocynaceae)
Authors: Morales J. Francisco
Published: November 2022

Resulting from the synopsis of Mandevilla Lindl. (Apocynaceae) in the states of Goiás and Brasília, Brazil, lectotypes are designated for 33 names: Amblyanthera versicolor (Stadelm.) Müll. Arg. var. stenosolen Müll. Arg., Angadenia reticulata Miers, Dipladenia acicularis K. Schum., D. gentianoides A. DC., D. gentianoides var. glabra Müll. Arg., D. gentianoides [var. velutina (Mart. ex Stadelm.) Müll. Arg.] subvar. longiloba Müll. Arg., D. illustris (Vell.) Müll. Arg. subf. hirsuta Müll. Arg., D. linariifolia A. DC., D. myriophyllum Taub. ex Ule, D. polymorpha Müll. Arg. subvar. glabra Müll. Arg., D. polymorpha var. intermedia Müll. Arg., D. tenuifolia (J. C. Mikan) A. DC. var. puberula A. DC., D. tenuifolia var. volubilis A. DC., D. tetradenia Rusby, D. vincaeflora Lem., Echites alexicacus Mart. ex Stadelm., E. illustris Vell., E. longiflorus Desf., E. maranhamensis G. Don, E. pastorum Mart. ex Stadelm., E. pohlianus Stadelm., E. pohlianus var. latifolius Stadelm., E. pubiflorus G. Don, E. pulchellus Gardner ex Hook., E. rosa-campestris Endl., E. rugosus Benth., E. spigeliiflorus Stadelm., E. tenuifolius J. C. Mikan, E. versicolor Stadelm., E. virescens A. St.-Hil., Macrosiphonia martii Müll. Arg., Macrosiphonia velame (A. St.-Hil.) Müll. Arg. var. goyazensis Müll. Arg., and Mandevilla barretoi Markgr. Eight second-step lectotypifications are completed for Echites coccineus Hook. & Arn., E. petreus A. St.-Hil., E. pinifolius A. St.-Hil., E. velame A. St.-Hil., Laseguea erecta (Vell.) Müll. Arg. subf. griseo-olivacea Müll. Arg., L. erecta var. glabrescens Müll. Arg., Macrosiphonia verticillata Müll. Arg. var. intermedia Müll. Arg., and Macrosiphonia verticillata var. peduncularis Müll. Arg. A neotype is designated for Amblyanthera versicolor (Stadelm.) Müll. Arg. var. olivacea Müll. Arg. Two new synonymies are proposed: Mandevilla barretoi Markgr. under M. tenuifolia (J. C. Mikan) Woodson, and M. bradei Markgr. under M. spigeliiflora (Stadelm.) Woodson.
Sinestesia dalam Novel "Tanjung Kemarau" Karya Royyan Julian
Authors: Milliana Milliana , Badrih Moh
Published: November 2022

Synesthesia is change. the meaning of the word form due to the use of responses from the two senses. This research discusses; what are the types and meanings of synesthesia contained in the novel Tanjung Kemarau by Royyan Julian. The method used in this research is descriptive qualitative with semantic studies. Data was collected by reading and note-taking techniques. Meanwhile, the data analysis used in the study, namely; transcribing, identifying, copying, analyzing, rechecking, and concluding. The novel found five types of synesthesia, namely; changes in the response of the sense of taste to the sense of sight, changes in the response of the sense of touch to the sense of hearing, changes in the response of the sense of touch to the sense of sight, changes in the response of the sense of sight to the sense of hearing, and changes in the response of the sense of hearing to the sense of sight. In addition, there are five meanings of synesthesia in it, namely the meaning based on the context of feeling (feeling), the setting context, the context of the goal, the context of tone, and the meaning of synesthesia based on the context of the relationship.Keyword: language;  novel; synesthesia; semantics Abstrak:Sinestesia  adalah  perubahan. makna bentuk kata akibat penggunaan tanggapan dari kedua indra. Penelitian ini membahas; apa saja jeniss dan makna sinestesia yang terdapat dalam novel Tanjung Kemarau  karya Royyan Julian, Metode yang digunakan dalam penelitian ini adalah kualitatif deskriptif dengan kajian semantik. Pengumpulan data dilakukan dengan teknik baca dan catat Sedangkan  analisis data yang digunakan dalam penelitian, yaitu; mentranskrip, mengidentifikasi, menyalin, menganalisis, pengecekan ulang, dan menyimpulkan. Dalam novel ditemukan lima  jenis-jenis sinestesia yakni; perubahan tanggapan indra perasa ke indra penglihatan, perubahan tanggapan indra peraba ke indra pendengaran, perubahan tanggapan indra peraba ke indra penglihatan, perubahan tanggapan indra penglihatan ke indra pendengaran, dan perubahan tanggapan indra pendengaran ke indra penglihatan. Selain itu, ada lima makna sinestesia di dalamnya yakni makna berlandaskan konteks perasaan (felling), konteks setting, konteks tujuan, konteks nada, dan makna sinestesia berlandaskan konteks relasiKata kunci: bahasa; novel; sineastesia; semantik
Sistem Organisasi Masyarakat Desa Kon dalam Novel "Haniyah dan Ala di Rumah Teteruga" Karya Erni Aladjai
Authors: Latifah Suci Ayu , Muhajir Muhajir , Sutejo Sutejo
Published: November 2022

A strong social system can create harmony, harmony, and peace. This kind of life is closely related to rural communities in fact suffering the same fate. This study will describe how the Kon village community organization system appears in the storytelling of the novel. The analysis uses the theory of literary anthropology. The research method uses descriptive qualitative, namely the findings of the data in the form of words and sentences in accordance with the formulation of the problem. The data collection technique used content analysis techniques sourced from the novel Haniyah and Ala di Rumah Teteruga by Erni Aladjai. The results of the research on the community organization system in the novel include (i) the kinship system; (ii) associations and associations; (iii) the state system; and (iv) the living unitary system. Portraits of community activities with their cultural environment are often found along the plot of storytelling and depictions of novel characters.Keywords: social system; anthropology; literatureAbstrak: Sistem kemasyarakatan yang kuat dapat menciptakan keharmonisan, kerukunan, dan kedamaian. Kehidupan semacam ini lekat dengan masyarakat pedesaan yang notabene bernasib sama. Penelitian ini akan mendeskripsikan bagaimana sistem organisasi masyarakat desa Kon yang tampak dalam penceritaan novel. Penganalisisan menggunakan teori antropologi sastra. Metode penelitian menggunakan deskriptif kualitatif, yaitu temuan data berupa kata-kata maupun kalimat sesuai dengan rumusan masalah. Teknik pengumpulan data menggunakan teknik analisis isi yang bersumber data novel Haniyah dan Ala di Rumah Teteruga karya Erni Aladjai. Adapun hasil penelitian sistem organisasi masyarakat dalam novel meliputi: (i) sistem kekerabatan; (ii) asosiasi dan perkumpulan; (iii) sistem kenegaraan; dan (iv) sistem kesatuan hidup. Potretisasi aktivitas masyarakat dengan lingkungan budayanya banyak ditemukan di sepanjang alur penceritaan dan penggambaran karakter tokoh-tokoh novel.Katakunci: sistem kemasyarakatan; antropologi;  sastra
EFECTO DEL ESTRÉS OSMÓTICO SOBRE LA GERMINACIÓN DE LAS SEMILLAS Y EL CRECIMIENTO DE PLÁNTULAS DE TRIGO (Triticum aestivum L.) Y AMARANTO (Amaranthus hypochondriacus L.)
Authors: Legaria-Solano Juan , Ponce-Romero Georgina , Muñoz-Orozco Abel
Published: November 2022

Se evaluó el efecto de diferentes potenciales osmóticos (Ψ s): 0, -0.05, -0.1, -0.2, -0.4, -0.8 y -1.6 Megapascales (MPa) sobre la absorción de agua, la germinación y el crecimiento de semillas de trigo (Triticum aestivum L.) y amaranto (Amaranthus hypochondriacus L.). Se analizó también la síntesis y degradación (disminución o desaparición) de proteínas bajo estrés osmótico. Las semillas de trigo y amaranto crecidas a Ψ s de 0 MPa absorben 94-95 % de su peso como agua a las 72 h de tratamiento, mientras que a un Ψ s de -16 MPa, el peso se incrementó únicamente 30 % y 20 % para el trigo y el amaranto respectivamente. Independientemente del s aplicado más del 50 % de la absorción de agua ocurre entre las 0 y 24 h en las semillas de trigo y entre las 0 y 12 h para las semillas de amaranto evaluadas en un periodo de 72 h. La sensibilidad de ambas especies al Ψ s de -0.8 MPa inhibe la germinación de semillas de trigo, pero el impacto sobre el crecimiento de la plántula es de diferente magnitud. Por otro lado, las semillas de amaranto germinan aún a Ψ s de -16 MPa, aun que no hay desarrollo posterior de la plántula. En trigo, la presencia de NaCI inhibe la síntesis de la mayoría de las proteínas presentes en la semilla germinada en condiciones normales, y en amaranto un s de -16 MPa mimetiza el patrón proteíco de la semilla seca. El NaCI evita la movilización (utilización-degradación) de las proteínas de almacenamiento en semillas de amaranto.
LAGUNERO 87: VARIEDAD DE FRIJOL PARA SIEMBRAS DE RIEGO EN LA COMARCA LAGUNERA, MÉXICO
Authors: Gaytán-Mascorro Arturo , Vargas-Aguilar Leoncio
Published: November 2022

En la Comarca Lagunera en promedio se ciembran 6,00 ha de froijol, aunque se han llegado a estblecer hasta 25,000 en el ciclo primavera verano de 1993, con un rendimiento promedio de 1300 kg/ha-1. Los problemas para la producción del frijol son la disponibilidad del agua para riego, las temperaturas altas (mayores a 42°C) durante el periodo reproductivo, y las variaciones en fotoperíodo, que prevocan falta de adaptación en las variedades provenientes de otras regiones.
Metode RGEC: Penilaian Tingkat Kesehatan Bank Sebelum dan Sesudah Merger Menjadi Bank Syariah Indonesia
Authors: Putri Siti Rahma , Rahmazaniati Linda
Published: November 2022

This study aims to understand the soundness of Islamic banks in Indonesia by using the RGEC method as set out in Bank Indonesia Regulation PBI No. 13/l/PBI/20ll. The assessment factors in the RGEC method are Risk Profile, GCG (Good Corporate Governance), Capital (Capital) and Profitability (Earnings). The subjects of this research are all companies belonging to Islamic banking listed on the Indonesia Stock Exchange for the period 2020-2021. The sampling technique used a purposive experiment. The audit strategy used is descriptive quantitative by ensuring the monetary proportion using the RGEC strategy. The consequences of this study prove that a bank that has a very healthy level of health category for the 2020 period is Bank Syariah Mandiri, while in 2021 the health level that is in the healthy category is BSI (Bank Syariah Indonesia).
Pengaruh Self Esteem dan Self Efficacy Terhadap Kualitas Audit (Studi Kasus Pada Inspektorat Kabupaten Bireun)
Authors: Agustina Neo , Sari Dewi Kemala , Andirfa Mulia
Published: November 2022

In ithe igovernment isector, iit iis inecessary ito icarry iout ian iaudit ito iensure ithat ithe imanagement iof istate ifinances iis icarried iout iproperly, itransparancy iand iaccountably iin iaccordance iwith ithe iapplicable ilaws iand iregulations iand ito iavoid icorrupt ipractices ion istate iassets. iThis istudy iaims ito iexamine ithe ieffect iof iself-esteem iand iself-efficacy ion iaudit iquality iat ithe iInspectorate iof iBireuen iRegency. iThe idata iused iin ithis istudy iis iprimary idata ias imany ias i36 isamples iwith isaturated isampling itechnique ior icensus. iThe imethod iused ito ianalyze ithe iindependent ivariable iwith ithe idependent ivariable iis ithe imultiple ilinear iregression imethod iand ithe iclassical iassumption itest. iThe iresults iof ithe istudy ipartially iself-esteem ihad ino ieffect ion iaudit iquality iat ithe iBireuen iRegency iInspectorate, iself-efficacy ihad ino isignificant ieffect ion iaudit iquality iat ithe iBireuen iRegency iInspectorate. iSimultaneously ishows ithat iself-esteem iand iself-efficacy ihave ia isignificant ieffect ion iaudit iquality iat ithe iBireuen iRegency iInspectorate.
Knowledge Description of S1 Nursing Study Program Students Semester II STIKes Santa Elisabeth Medan about BSE in the Santa Agnes Girls Dormitory 2022
Authors: Purba Meriati Bunga Arta , Siringo-ringo Magda , Pardede Riska Debora
Published: November 2022

To detect breast cancer early, the effort that women can do by means of Breast Self-Examination or BSE. BSE is an increase in a woman's interest in the state of her own breasts. Women's knowledge still minimal about accurate information on breast cancer and early detection efforts. Understanding of breast cancer and early detection efforts still need to be improved so that the chances of recovery and the number of life ambitions increase. So that the morbidity and mortality of breast cancer sufferers reduced and the quality of life of breast cancer patients is increased. To describe the knowledge of S1 Nursing Study Program Students Semester II STIKes Santa Elisabeth Medan about BSE the Santa Agnes Girls Dormitory in 2022. This type of research is descriptive with a total sampling technique with data collection techniques carried out using a questionnaire distributed via google form. The results of 80 respondents who had sufficient knowledge were 63 respondents (79%) and 17 respondents (21%). Students are expected to increase their knowledge about BSE by digging more information about BSE, through the internet or other mass media. Thus, students more confident in implementing and carrying out breast self-examination measures within themselves, so that breast cancer detected as early as possible and the number of breast cancer sufferers decrease.
The Effect of Giving Hatha Yoga Exercise on Increasing Sleep Quality in the Elderly in Karangkates Village
Authors: Devanti Naftalia Rofiliana , Utami Kurnia Putri
Published: November 2022

Background: The elderly have several health problems including decreased physical and mental functions of the elderly including decreased sleep quality. Sleep quality is important for the quality of human life. Sleep quality is one of the conditions in which the individual sleeps and can increase the feeling of freshness and fitness when awakened from sleep. Poor sleep quality can interfere with daily activities in the elderly. Hatha Yoga is a low impact aerobic exercise that can be given to the elderly to improve sleep quality. Objective: To determine the effect of giving hatha yoga exercise on improving sleep quality in the elderly. The research method used a quasi-experimental research design with One Group Pre-test-Post-test Design with 30 elderly respondents in Karangkates Village. Respondents were elderly who met the inclusion and exclusion criteria. The instrument in this study used the Pittsburgh Sleep Quality Index Questionnaire. Giving Hatha Yoga Exercise intervention 3 times a week for 4 weeks. Research Results: Based on the analysis test using the Wilxocon test, the p-value of 0.000 <0.05 was obtained, then H0 was rejected and H1 was accepted, which means that there is an effect of hatha yoga exercise on improving sleep quality in the elderly in Karangkates Village. Conclusion: There is an effect of giving hatha yoga exercise on improving sleep quality in the elderly in Karangkates Village.
Comparative Effect of Cinnamon Powder and Red Ginger Powder for Menstrual Pain Primary Dysmenorrhea in Adolescent
Authors: Anuhgera Diah Evawanna , Sitorus Riris , Octora Debi Dinha
Published: November 2022

Menstrual pain is a problem with interferes by women in every menstrual cycle. This can interfere with the activities of women such as dizziness, nausea, stomach cramps, and productivity of women. Several non-pharmacologic treatment can help reduce menstrual pain such as giving cinnamon and red ginger. The purpose of this study was to compare the effectiveness of cinnamon powder and red ginger to decrease menstruation in adolescents with primary dysmenorrhea.

This type of research is a quasi-experimental type of time series design. The sample in this study were all first semester female students in the Nursing Study Program at the Lubuk Pakam Medistra Health Institute who experienced primary dysmenorrhea as many as 28 people. The sampling technique used is simple random sampling. In this study there were two groups, namely the control group with the administration of ginger powder while the intervention group with the administration of cinnamon powder. The process was given an intervention for 3 days and the use of the research instrument to measure menstrual pain was the Numeric Rating Scale (NRS). Data analysis used independent t-test and Repeated Measured Anova test.

The results showed that there was a difference in mean pain before and before cinnamon powder at 24 hours of intervention after (p<0.001) while red ginger drink powder showed no significant difference in mean pain before and before the intervention in the first 24 hours of intervention (p = 0.112). However, at 48 hours and 72 hours of intervention for the two groups, there was a significant difference in the decrease in mean menstrual pain in primary dysmenorrhea (p<0.001).

Cinnamon drink powder is more effective than red ginger drink powder in reducing primary dysmenorrhea menstrual pain. Cinnamon and red ginger can be used as an effective non-pharmacological treatment intervention and obtained as a treatment for primary removal. Midwives can educate and apply the intervention of cinnamon and red ginger drinks to adolescents with primary dysmenorrhea.