bluuebunny/crossref_metadata_2025 huggingface dataset:
THE METAVERSE AS A GLOBAL ECONOMIC TREND
Authors: Alаbinа T. A. , Dzangieva K. S. , Yushkovskaya A. A.
Published: June 2022

The article discusses a new global trend in the development of the economy called the “metaverse”, announced in October 2021 by Mark Elliot Zuckerberg as a result of improved interaction between a person and new information technologies (digitalization), including the real world, virtual space, the spiritual world and the fantasy world as interconnected levels. Based on the approaches of various authors, the author’s vision of the metaverse as a transformational stage in the subsequent development of the digital economy is proposed through the use of end-to-end technologies such as Big data, gamification technologies, augmented (AR) and virtual reality (VR), blockchain and others: the concept is defined, presented the main elements, the principles of the functioning of the metaverse, its advantages and disadvantages are disclosed. In the course of the study of futurologists’ forecasts, a strategic assumption was made that the metaverse as a global economic trend can contribute to the transformation of the chaos of future digitalization into an interaction system, become a platform for economic entities and a successful strategic project.
STATISTICAL ANALYSIS OF RURAL POVERTY FACTORS IN THE RUSSIAN FEDERATION
Authors: Grigorieva E. G. , Shilova E. V. , Stakutis S. Z.
Published: June 2022

The article presents the results of a correlation analysis of the ratio and dynamics of poverty in the constituent entities of the Russian Federation. The methodological foundations of the study are presented as a review of Russian and foreign studies of the ratio and reasons of poverty. We proposed the classification of the Russian constituent entities by the ratio of urbanization and conducted the two-dimensional grouping of constituent entities with an average ratio of urbanization by the ratio of poverty in 2019. The results of this study confirm the spread of poverty in rural areas and a high level of differentiation of constituent entities by poverty indicators.

Multiple correlation analysis allowed us to estimated models of multiple regressions and identifies significant independent variables of the ratio and dynamics of poverty in constituent entities with an average ratio of urbanization. It is concluded that the poverty ratio is lower in those constituent entities where tourism, manufacturing, animal husbandry, individual entrepreneurship, higher education and postgraduate studies are better developed. But poverty reduction is more successful in those constituent entities where trade, transport and warehousing logistics are developing.

In general, the study confirms the need to take into consideration specific regional features of the development of Russian constituent entities in the fight against poverty, the use of a targeted integrated approach in the selection of measures to reduce poverty.
STRATEGIC PLANNING TRENDS IN THE REGIONS (ON THE EXAMPLE OF THE ALTAI TERRITORY)
Authors: Sannikova I. N. , Borisova D. E. , Krayushkin M. G.
Published: June 2022

The article contains the features of regional strategic planning in the context of the implementation of the national priority — people-saving. The purpose of the study is to determine the key vector of regional strategic planning, taking into account current trends and realities of the pandemic. The study is based on official data from the Federal State Statistics Service. The basis of the research methodology is a logical-epistemological toolkit with a linkage of general scientific methods of comparison and correlation analysis. It was found that the mortality rate of the population is of critical importance in achieving national strategic priorities. And, consequently, the identification of factors of an increased mortality rate is a priority analytical task in the implementation of a regional strategy of socio-economic development.

The results of the studies carried out provide the initial basis for the development of municipal strategies. In order to concretize targeted management decisions, it is further necessary to determine the relationship between mortality from specific diseases and the availability of doctors in the relevant specialties, with access to the schemes of targeted training of doctors for municipalities. More ambitious further tasks — to identify factors and assess the strength of their influence on the mortality of the population; to create an integrated model using Data Mining tools, which provides support for making management decisions aimed at reducing mortality in the region.
O Índice de Segurança Hídrica do Brasil e o Semiárido Brasileiro: Desafios e Riscos Futuros
Authors: Brito Higor Costa , Maia Araújo de Brito Yáscara , Alexandra Alves Rufino Iana
Published: June 2022

No Semiárido Brasileiro a escassez de água é recorrente, agravada por secas históricas e pelo aumento da demanda de água. Na busca por mitigar tais efeitos, o estudo objetiva elaborar uma dimensão para o Índice de Segurança Hídrica do Brasil (ISH), capaz de representar o risco associado às interferências antrópicas e ao fenômeno da seca na região. A metodologia visa adicionar uma quinta dimensão ao ISH, que considera as dimensões humana, econômica, ecossistêmica e de resiliência. O intuito é aprimorar o mapa de segurança hídrica previsto para o ano de 2035, aplicado à Bacia do Alto Curso do Rio Paraíba. A nova dimensão, denominada Dimensão de Risco, utiliza um produto de uso e cobertura da terra simulado para 2035 e o Mapa Cumulativo de Secas. OS resultados constatam a carência de informações em algumas dimensões do ISH, visto que diversas ottobacias têm o seu ISH representado por apenas uma dimensão. Nesse âmbito, a Dimensão de Risco agregou informações baseada na demanda e oferta de água, ao considerar todas as áreas de uso antrópico e as condições de seca que assolam a região, alterando o ISH de diversas localidades. Logo, o trabalho contribui para refinar o conceito de risco adotado na elaboração do ISH, principalmente para regiões de maior vulnerabilidade climática e social como o Semiárido Brasileiro, onde o risco transcende quantificações de oferta e demanda de água e afeta diretamente o desenvolvimento humano, político e econômico da população, impactando as ações humanas que ocorrem na região e, consequentemente, sua segurança hídrica.
Energy Drink Consumption and Increased Risk of Smoking and Alcohol and Sweetened Beverages Use among University Students
Authors: Elslami Ahmad , Bastami Fatemeh , Ardalan Arash , Almasian Mohammad , Alibakhshi Maryam
Published: June 2022

Objective: Energy drink consumption has been increasing among youth. In this study, we aimed to examine the patterns of energy drink consumption and their relationships with the use of sweetened beverages such as soda and packaged fruit juice as well as alcohol consumption and smoking among college students. Methods: This was a cross-sectional analytical study in which data were collected during the 2018-2019 academic year for 9 months from October to July. Our sample was a random selection of 373 students attending Isfahan University of Medical Sciences. We used logistic regression analysis, chi-square, and independent t-tests for data analysis. Results: Overall, 31.6% of men and 27% of women had consumed energy drinks. Men consumed energy drinks 1.3 times more than women did. Preferring the taste was the most frequent reason (30.8%) for energy drink consumption. Having energy drinks was associated with consumption of sweetened beverages and alcohol (p < .001). The mean consumption of sweetened beverages and alcoholic drinks, and smoking was significantly higher among men than women (p < .05). Conclusion: A sizable percentage of students consumed energy drinks because of the taste. This indicates that they should be informed about the harmful ingredients in these drinks.
Aktifitas Antibakteri Isolat Bakteri Asam Laktat Saluran Pencernaan Kuda Laut (Hippocampus kuda Bleeker, 1852) Terhadap Vibrio harveyi
Authors: Sandi Fionica May , Subagiyo Subagiyo
Published: June 2022

Seahorses (Hippocampus kuda) have high economic value in global trade. Therefore, to meet market demand, cultivation efforts have been carried out. Vibriosis caused by Vibrio harveyi is a disease that is often reported to affect seahorses. In this study, lactic acid bacteria were isolated from the digestive tract of seahorses, and were selected based on their antibacterial activity against V, harveyi. Antibacterial activity test was carried out by agar diffusion method. Isolates with antibacterial activity were identified based on their morphological and biochemical characteristics. The results of this study obtained 3 (three) LAB isolates that were active against V. harveyi from a total of 45 isolates, namely SPKL 34, SPKL 08 and SPKL 58. The SPKL 34 isolate had the highest antibacterial activity. The three isolates were identified as lactobacillus sp  Kuda laut (Hippocampus kuda) memiliki nilai ekonomi tinggi sebagai salah satu jenis komoditas perdagangan global. Oleh karena itu untuk memenuhi permintaan pasar diantaranya telah dilakukan upaya budidaya. Vibriosis yang disebabkan oleh Vibrio harveyi merupakan penyakit yang sering dilaporkan menyerang Kuda Laut. Pada penelitian telah dilakukan pencarian jenis-jenis bakteri asam laktat (BAL) yang berasal dari saluran pencernaan Kuda Laut yang memiliki aktivitas antibakteri terhadap V. harveyi. Uji aktivitas antibakteri dilakukan dengan metode difusi agar. Isolat yang memiliki aktivitas antibakteri diidentifikasi berdasarkan karakteristik morfologi dan biokimia. Hasil penelitian ini memperoleh 3 (tiga) isolat BAL yang aktif terhadap V. harveyi dari total 45 isolat yaitu SPKL 34, SPKL 08 dan SPKL 58. Isolat SPKL 34 memiliki aktivitas yang paling tinggi yaitu dengan rerata luas zona hambat sebesar 4,14±0,60 mm. Hasil identifikasi menunjukkan ketiga isolat merupakan Lactobacillus sp. dengan tingkat kemiripan >80%.
Pemodelan Pola Sedimentasi di Muara Cisadane untuk Mendukung Pengembangan Terpadu Pesisir Ibukota Negara
Authors: Wibowo Mardi , Khoirunnisa Hanah , Wardhani Khusnul Setia , Wijayanti Reni
Published: June 2022

NCICD is one of the national strategic programs to deal with coastal problems in Jakarta. One alternative structure to be built is WLP or known as coastal resort. As an initial step to make it happen, BAPPENAS plans to build a WLP pilot plan around the S. Cisadane estuary. One of the main considerations for designing the WLP layout is the process and pattern of sedimentation around the Cisadane estuary. Therefore, computational modeling of sediment transport around the Cisadane estuary was carried out for a period of 1 year (August 2020-July 2021). This modeling uses MIKE-21 module MIKE21/3 Integrated Models software which combines hydrodynamics and cohesive sediment transport models. Based on the results of this modeling, it is known that there are differences in sediment transport patterns in the west and east monsoons. During 1 year, changes in the thickness of the bottom sediment around the estuary of S. Cisadane ranged from -0.4 to 0.7 m with a mean of 0.086 m. Coastal reservoir design must take into the very dynamic sedimentation process around the Cisadane estuary.   Pengembangan Terpadu Pesisir Ibukota Negara (PTPIN) merupakan salah satu program strategis nasional untuk menangani permasalahan pesisir di Jakarta. Salah satu alternatif struktur yang akan dibangun adalah WLP atau dikenal sebagai coastal reservoir. Sebagai langkah awal mewujudkannya BAPPENAS merencanakan membangun pilot plan WLP di sekitar muara S. Cisadane. Salah satu pertimbangan utama untuk mendesain layout WLP adalah proses dan pola sedimentasi di sekitar muara Cisadane. Oleh karena itu dilakukan pemodelan komputasi transpor sedimen di sekitar muara Cisadane selama kurun waktu 1 tahun (Agustus 2020-Juli 2021). Pemodelan ini menggunakan software MIKE-21 module MIKE21/3 Integrated Models yang menggabungkan model hidrodinamika dan transpor sedimen kohesif. Berdasarkan hasil pemodelan ini diketahui bahwa terdapat perbedaan pola transpor sedimen di musim barat dan musim timur. Selama 1 tahun, perubahan ketebalan sedimen dasar di sekitar muara S. Cisadane berkisar -0,4-0,7 m dengan rerata 0,086 m. Pola sedimentasi yang sangat dinamis harus mendapatkan perhatian khusus dalam merancang waduk lepas pantai.
Korelasi Klorofil-a dengan Nutrien dan Kualitas Perairan di Pulau Seruni Karimunjawa Indonesia
Authors: Widiaratih Rikha , Suryoputra Agus Anugroho Dwi , Handoyo Gentur
Published: June 2022

Seruni Island is one of the islands located in the easternmost and is an uninhabited island in Karimunjawa, Jepara Regency, Central Java. Seruni Island has a tourist attraction, namely a stretch of white sand, coral reefs, and which is currently used by local people for seaweed cultivation. There are still many tourism opportunities and marine utilization that have not been utilized optimally. Knowing the availability of chlorophyll-a and its correlation with nutrients (ammonia, nitrate, and phosphate) and water quality on Seruni Island can provide an initial overview of the fertility conditions of the waters on Seruni Island so that other marine utilization opportunities can be wide opened. In situ data are collected such as seawater samples, which are then analyzed in the laboratory, as well as water quality parameters including salinity, pH, DO, temperature and brightness. Although Seruni Island is an uninhabited island, however, it is possible that there will be runoff from the surrounding inhabited islands, which will increase the concentration of chlorophyll-a. The results showed that chlorophyll-a had a high and negative correlation with nutrients, namely ammonia (r=-0.985), and water quality, namely temperature and brightness (r=-0.895 and r=-0.734).  Pulau Seruni merupakan salah satu pulau yang lokasinya terletak paling timur dan merupakan pulau tidak berpenghuni di Karimunjawa, Kabupaten Jepara Jawa Tengah. Pulau Seruni memiliki daya tarik wisata yaitu hamparan pasir putih, terumbu karang, dan yang saat ini dimanfaatkan masyarakat setempat untuk budidaya rumput laut. Masih banyak peluang wisata dan pemanfaatan bahari yang belum dimanfaatkan secara optimal. Dengan mengetahui ketersediaan klorofil-a dan korelasinya terhadap nutrien (ammonia, nitrat dan fosfat) dan kualitas perairan di Pulau Seruni dapat memberikan gambaran awal terkait kondisi kesuburan perairan yang ada di Pulau Seruni, sehingga dapat terbuka peluang pemanfaatan bahari lainnya. Data in situ yang diambil berupa sampel air laut, yang selanjutnya dianalisis di laboratorium, serta parameter kualitas perairan meliputi salinitas, pH, DO, suhu dan kecerahan. Walaupun Pulau Seruni merupakan pulau yang tidak berpenghuni, namun demikian tidak menutup kemungkinan terdapat limpasan massa air yang berasal dari pulau sekitarnya yang berpenghuni yang berdampak pada meningkatnya konsentrasi klorofil-a. Hasil penelitian menunjukkan klorofil-a memiliki korelasi yang tinggi dan bernilai negatif dengan nutrient, yaitu ammonia (r=-0,985), dan kualitas perairan yaitu suhu dan kecerahan (r=-0,895 dan r=-0,734). Kata kunci : klorofil-a, nutrient, kualitas perairan, Korelasi, P.Seruni
Odporovatelnost právních jednání zkracujících věřitele dle občanského zákoníku a insolvenčního zákona – procesní aspekty
Authors: Smolík Petr
Published: June 2022

The paper deals with the new regulation of the relative ineffectiveness of legal acts in the Civil Code and compares it with the special regulation of the ineffectiveness of legal acts of the debtor in the Insolvency Act, which was adopted several years earlier. The basis of the treatise is the substantive legal regulation of the institute, but due to its nature, the procedural aspects – the so-called voidability – cannot be separated from the substantive aspects. The interpretation therefore focuses on the procedure of creditors towards the debtor or third parties when applying relative ineffectiveness and focuses on avoidance actions (both general and special), which are the basic instrument of the legal protection of creditors. With regard to the above-mentioned double regulation there are also problems in practice when both variants occur concurrently. A specific problem is also represented by the clash of the relative ineffectiveness of a legal act with its invalidity and its resolution especially in the area of insolvency law.
Právní jednání rodiče při správě jmění dítěte aneb jak otočit podstatu a účel zákona o 180°
Authors: Zuklínová Michaela
Published: June 2022

The administration of the child’s assets and debts as a part of parental responsibility is one of the important duties and rights of parents, as well as the duty and the right of the legal representation of the child. This article is trying to compare the original legal text of the relevant law, i.e., the article 898 of the Czech Civil Code (at the time of the codification of the Civil Code) and new legal text (when law No. 192/2021 has novelized the provision in question). The problem/question in the protection of the property rights of a child is researched above all. Several legal acts of parents (as the legal guardians of a child) need the court’s approval. According to the original law, a parent’s legal act without the court’s approval has been refused. Is it was watched as a legal nothing (putative act or no-act). In the view of constitutional law, this way of protecting a child was the maximum possible choice. But the new law has diminished the protection to the minimum, because now such imperfect parent’s legal act may be declared invalid by a court only if the child (or another person) invokes the invalidity (voidable act), and – above all – if the legal act has no harmful consequence for the child, a court does not have to declare the invalidity of such legal act at all.
Držba v novém pojetí
Authors: Zvára Michael
Published: June 2022

The article deals with the re-established approach to possession in the Czech law. Attention is paid to the definition of the object of possession and the honesty in the law of possession. The article analyses the re-established concept of honesty in the law of possession in relation to the historical legal framework on the current territory of the Czech Republic and in relation to the Austrian law. The article also refers to the new institute of extraordinary prescription and itʼs relation to the law of possession in general and to ordinary prescription. It’s also refers to the relationship between the legal framework of possession and unjust enrichment, whereas the relationship between these concepts is not solved in a completely satisfactory way.
Soudní kontrola nepřiměřených (zneužívajících) ujednání z úřední pravomoci
Authors: Vyskočilová Silvia
Published: June 2022

The contribution deals with the issue of ex officio control of unfair contract terms by courts, which follows from Council Directive 93/13/EEC of 5 April 1993 on unfair contract terms in consumer contracts and from the decision-making practice of the European Court of Justice. The author deals with the issue of the court’s procedure in civil proceedings during the application of the unfairness test, especially with regard to consequences.
Stavba jako předmět díla v občanském zákoníku
Authors: Pohl Tomáš , Sedláček Miroslav
Published: June 2022

Work means the construction, maintenance, repair, or alteration of a structure or part thereof. Section 2623 et seq. of the Civil Code provides for certain exceptions to the general regulation of a contract for work, contracts for the alteration of immovable property, and for contracts for the construction, repair, or alteration of a construction. In matters not regulated by these provisions, the general regulation of work contracts also applies to construction contracts. The aim of the authors’ article is to draw attention to these exceptions, to define the concept of construction, to focus on construction as an object of the work, including related issues, as well as on the legal regulation of works with intangible results.
Zastoupení člena společenství vlastníků jednotek na zasedání shromáždění
Authors: Dvořák Tomáš
Published: June 2022

This scientific study deals with the issue of representation of a member of the community of unit owners according to the legal regulation of housing co-ownership contained in Act No. 89/2012 Sb., The Civil Code, as amended, at the meeting of the Assembly. The study deals with both legal representation and guardianship representation, and especially contractual representation. When interpreting the law, the legal regulation and case law of the representation of a partner of a capital trading company at a meeting of the General Meeting is taken into account, unless this is prevented by the wording of the law or the nature of the matter.
Evaluation of fractures using conventional and FMI logs, and 3D seismic interpretation in continental tight sandstone reservoir
Authors: Qiu Xiangliang , Tan Chengqian , Lu Yuanyuan , Yin Shuai
Published: June 2022

Due to the complex pore structures and strong heterogeneity of fractured reservoirs, it is a hot and difficult point in petroleum geology to identify fractures using logging principles. In this paper, taking the tight sandstone reservoir of the Chang 8 Member in the Huanjiang Oilfield as an example, field outcrops, cores, thin sections, and logging identification methods were used for quantitative description and fine logging evaluation of fractures. The research shows that high-angle, medium-low-angle, near-vertical, and horizontal fractures are developed in the Chang 8 Member of the Huanjiang Oilfield. The main ones are high-angle fractures, followed by horizontal fractures with a low degree of fillings. Under the constraints of core and imaging logging data, three fracture sensitivity logging parameters of acoustic wave time difference, natural gamma, and dual induction-octalateral resistivity were optimized, and a comprehensive fracture probability index was proposed. Seventy-nine fracture development intervals were identified based on log curve characteristics and fracture probability indexes. The coincidence rate of fracture logging identification results with the core observation and imaging logging interpretation is 80.6%. The research results can provide a theoretical basis for the efficient development of fractured continental tight sandstone reservoirs in similar areas.
Quantitatively determine the dominant driving factors of the spatial-temporal changes of vegetation-impacts of global change and human activity
Authors: Wang ShiJun , Ping Chang , Wang Ning , Wen Jing , Zhang Ke , Yuan Kun , Yang Jun
Published: June 2022

The differences in spatial-temporal distribution patterns and dominant driving factors of vegetation evolution among sub-regions during different historical periods were not clear. Therefore, this study introduced the gravity center model and geodetector to analyze the spatial-temporal change characteristics and dominant driving factors of normalized difference vegetation index (NDVI) in China during 1981–2019 from the perspective of geographic divisions. Results showed that (1) during 1981–2019, the average vegetation coverage in China showed an increasing trend and zones with obviously increasing vegetation NDVI were mainly distributed in the middle reaches of the Yellow River basin and the upper reaches of the Yangtze River. (2) During 1981–2019, the gravity center of national vegetation NDVI was mainly concentrated in Yan’an City and Tongchuan City, showing a southward migration trend as a whole, which indicates that the increment and growth rates of the southern part were greater than those of the northern part. (3) The growth of vegetation in southern China was primarily affected by the temperature, while that of northern China was largely influenced by precipitation. (4) During 1981–2019, the dominant interactive factors of vegetation change for all subregions changed greatly: natural factor (climate or terrain) ∩ other factors → landuse ∩ other factors.
Regional differences in utilization of 17α-hydroxyprogesterone caproate (17-OHP)
Authors: Hart Jessica M. , Hakim Joe B. , Wylie Blair J. , Beam Andrew L.
Published: June 2022

Objectives

To describe regional differences in utilization of 17α-hydroxyprogesterone caproate (17-OHP).

Methods

Retrospective cohort study of a large, US commercial managed care plan claims database with pharmacy coverage from 2008 to 2018. Singleton pregnancies with at least one prior spontaneous preterm birth (sPTB) were included. Regional and state-based differences in 17-OHP use were compared. Data were analyzed using t-tests and Fisher’s exact tests.

Results

Of the 4,514 individuals with an indication for 17-OHP, 580 (12.8%) were prescribed 17-OHP. Regional and state-based differences in 17-OHP utilization were identified; Northeast 15.7%, Midwest 13.7%, South 12.0%, and West 10.4% (p=0.003).

Conclusions

While significant regional differences in 17-OHP utilization were demonstrated, 17-OHP utilization remained low despite this cohort having insurance through a US commercial managed care plan. Suboptimal utilization demonstrates a disconnect between research and uptake in clinical practice. This underscores a need for implementation science in obstetrics to translate updated recommendations more effectively and efficiently into clinical practice.
Nietzsche als Leser
Authors: von Seggern Hans-Gerd
Published: June 2022

Nietzsche as Reader.
This collective review summarizes and critically reflects on the results of four recent publications. On the one hand, this involves a typology of the specific mode of reception with which Nietzsche often incorporates seemingly selective readings into his thought and subsequently allows them to become productive in his writings; on the other hand, I am also dealing with the exceptional importance of Italian philology for current research into the influences on Nietzsche. The German-Italian conference volume Corrispondenze estetiche focuses on Heinrich Heine’s influence, but it also discusses in a sophisticated way the tension between the two authors in the context of the history of nineteenth-century aesthetics. Vivetta Vivarelli’s study discusses the motif of eternal recurrence in various references to contemporary poetry, while Benedetta Zavatta presents the ultimate study of Nietzsche’s reading of Ralph Waldo Emerson.
Synthesis, characterization, and theoretical investigation of 4-chloro-6(phenylamino)-1,3,5-triazin-2-yl)asmino-4-(2,4-dichlorophenyl)thiazol-5-yl-diazenyl)phenyl as potential SARS-CoV-2 agent
Authors: Eno Ededet A. , Louis Hitler , Unimuke Tomsmith O. , Egemonye ThankGod C. , Adalikwu Stephen A. , Agwupuye John A. , Odey Diana O. , Abu Abu Solomon , Eko Ishegbe J. , Ifeatu Chukwudubem E. , Ntui Tabe N.
Published: June 2022

The synthesis of 4-chloro-6(phenylamino)-1,3,5-triazin-2-yl)amino-4-(2,4 dichlorophenyl)thiazol-5-yl-diazenyl)phenyl is reported in this work with a detailed structural and molecular docking study on two SARS-COV-2 proteins: 3TNT and 6LU7. The studied compound has been synthesized by the condensation of cyanuric chloride with aniline and characterized with various spectroscopic techniques. The experimentally obtained spectroscopic data has been compared with theoretical calculated results achieved using high-level density functional theory (DFT) method. Stability, nature of bonding, and reactivity of the studied compound was evaluated at DFT/B3LYP/6-31 + (d) level of theory. Hyper-conjugative interaction persisting within the molecules which accounts for the bio-activity of the compound was evaluated from natural bond orbital (NBO) analysis. Adsorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) properties of the experimentally synthesized compound was studied to evaluate the pharmacological as well as in silico molecular docking against SARS-CoV-2 receptors. The molecular docking result revealed that the investigated compound exhibited binding affinity of −9.3 and −8.8 for protein 3TNT and 6LU7 respectively. In conclusion, protein 3TNT with the best binding affinity for the ligand is the most suitable for treatment of SARS-CoV-2.
Process intensification and digital twin – the potential for the energy transition in process industries
Authors: Huynh Thien An , Zondervan Edwin
Published: June 2022

The work defines and discusses process intensification (PI) and digital twin (DT) as potential tools to accelerate the energy transition through their applications in the process industries. The PI technologies take advantage of innovative principles in equipment design and control to improve the physical process, while the DT offers the virtual model of the plant as an environment for production optimization. The effects of both tools on the energy transition are evaluated not only from the point of applications but also from the possibility of implementation and barriers in process industries. Although they are beneficial, the deployment of PI and DT requires not only infrastructure and capital investment but the knowledge and cooperation of different levels of plant personnel. Besides review of individual implementation, this work explores the concept of combining PI and DT which can make them the enabler of each other and bring a breakthrough in optimization of process design and control.
Statistical damage constitutive model for the two-component foaming polymer grouting material
Authors: Du Mingrui , Wang Zhenyang , Fang Hongyuan , Li Manjun , Zhao Peng
Published: June 2022

Two-component foaming polymer (TFPU) grouting material is increasingly used in civil engineering. Its compressive strength is key to achieving the desired enhancing effect. The constitutive model of TFPU grouting material is a theoretical basis to evaluate the strength performance, which, however, is not fully understood. Here the uniaxial compression experiment of TFPU samples of different densities (0.11–0.53 g·cm−3) was conducted. Based on the stress–strain curves, the damage evolution equation of each sample was obtained by function fitting, followed by the establishment of statistical damage constitutive model. The model was simplified to a universal function with density as the argument. Results show that the stress–strain curves contain the initial compression stage, linear elastic stage, yield stage, yield plateau stage, and strain hardening stage regardless of the varied density. The variation laws of the damage with strain conform to the form of first-order decay exponential function. The theoretical stress–strain curves are in good agreement with the experimental ones, indicating that the statistical damage constitutive model can well reflect the mechanical behavior of TFPU grouting material. With this constitutive model, the mechanical properties of TFPU grouting material can be obtained according to the density alone, which is more convenient for practical engineering applications.
Metal organic frameworks (MOFS) as non-viral carriers for DNA and RNA delivery: a review
Authors: Soriano-Giles Gabriela , Giles-Mazón Edwin A. , Lopez Nazario , Reinheimer Eric , Varela-Guerrero Victor , Ballesteros-Rivas María F.
Published: June 2022

Metal-Organic Frameworks (MOFs) are a class of crystalline materials that, thanks to their large surface area and high porosity, allow them to be used in various areas of knowledge. This diversity of applications is due to the metal ions and the organic binders that compose them, but it is also important to highlight the ability of MOFs to function as hosts for a great variety of molecules of very different sizes and chemical properties. The first existing approaches for incorporating biomolecules in MOFs are discussed: pore encapsulation, surface binding, covalent binding, and in-situ encapsulation. Next, we discuss the obstacles of designing MOFs for effective gene delivery and how to enhance the gene delivery using different strategies.
Resilience, Trauma, and Coping
Authors: Friedberg Ahron , Malefakis Dana
Published: June 2022

The study and use of resilience is of the utmost importance to psychodynamic psychiatry. It is deeply ingrained in ideas about well-being and the treatment and care of patients. However, its neurobiology is incompletely understood, its terminology and relation to trauma and coping not well defined, and its efficacy underutilized in clinical practice. This article reviews the scientific literature on resilience, especially as it relates to trauma and coping. It also attempts to point the way for its greater application in psychiatry and mental health by utilizing resilience in more informed and individualized approaches.
Class, Conflict, and Power between Hegemony and Critical Knowledge
Authors: Dević Ana
Published: June 2022

This article opens by situating the Yugoslav academic perspectives on class and politics within the framework of recent studies dealing with class in post-socialist Europe. It then presents the ways in which the first Yugoslav dissidents understood the “new class” (the embourgeoisement of the party elite), followed by a review of a large number of studies on the disintegration of workers’ self-management project, students’ protests, and workers’ strikes. The diverse scope of research conducted between the 1960s and 1980s provided a corrective to the League of Communists’ hegemonic perceptions of the growing social inequalities, the causes of the economic crisis, and the stalemates of political decision-making, showing the deepening, while “invisible,” sense of powerlessness among workers and the opaqueness of the polycentric, increasingly fragmenting and clashing centers of political power. In the conclusions, changes in the perceptions of class in post-Yugoslav states are discussed.
Songs for Ordinary People
Authors: Daniel Ondřej
Published: June 2022

This article aims to illuminate the links between culture and class in the post-socialist years in the Czech Republic. To this end, it considers the reception of two music acts—the country folk duo Bratři Nedvědi in the 1990s and the “nationalist rock” band Ortel in the 2010s—and discusses the labeling of their fans based on their social class profiles. My analysis draws on mainstream Czech media coverage of these acts, materials reflecting fans’ perspectives, and broader scholarly debates about the links between music consumption and social class. One similarity between these bands lay in their decision to forsake their original subcultural fans for a more mainstream audience. A second commonality relates to the dismissal of their mainstream fans by cultural elites, who saw them as backward and out of step with the norms of liberal democracy and Western capitalism. These critics often described these types of Czech music as lowbrow and regressive. Meanwhile, the two bands continued to insist that they were making songs for “ordinary people” rather than elites: their fan bases, while not homogenous, remained largely working class. This study considers key intersections between class, age, ethnicity, and gender in Czech post-socialist society. I argue that certain kinds of local musical taste reflect class differences, which are further shaped by age, gender, and political orientation.
Maternal secretin ameliorates obesity by promoting white adipose tissue browning in offspring
Authors: Xue Lamei , Sun Juan , Liu Jinxin , Hu Chaoping , Wu Dandan , Nie Chenzhipeng , Zhang Kuiliang , Wang Yu , Zhao Lei , Li Xihua , Lu Yan , Zhang Li , Zhang Duo , Fan Mingcong , Qian Haifeng , Jiang Haowen , Wong Jiemin , Li Yuying , Ying Hao , Chow Billy KC , Wang Li , Li Yan
Published: June 2022

Our knowledge of the coordination of intergenerational inheritance and offspring metabolic reprogramming by gastrointestinal endocrine factors is largely unknown. Here, we showed that secretin (SCT), a brain‐gut peptide, is downregulated by overnutrition in pregnant mice and women. More importantly, genetic loss of SCT in the maternal gut results in undesirable phenotypes developed in offspring including enhanced high‐fat diet (HFD)‐induced obesity and attenuated browning of inguinal white adipose tissue (iWAT). Mechanistically, loss of maternal SCT represses iWAT browning in offspring by a global change in genome methylation pattern through upregulation of DNMT1. SCT functions to facilitate ubiquitination and degradation of DNMT1 by activating AMPKα, which contributes to the observed alteration of DNMT1 in progeny. Lastly, we showed that SCT treatment during pregnancy can reduce the development of obesity and improve glucose tolerance and insulin resistance in offspring of HFD‐fed females, suggesting that SCT may serve as a novel biomarker or a strategy for preventing metabolic diseases.
Markerless Augmented Reality (AR) pada Media Pembelajaran Pengenalan Komponen Transmisi Manual Mobil
Authors: Indriyani Triska Widya , Suryanto Agus
Published: June 2022

Nowdays technology has developed very rapidly. Technological development that are currently being developed by many game developers and other applications, is Augmented Reality (AR). AR can be used as an alternative learning media, such as for the introduction of manual transmission components in cars. The study was aimed to develop a learning media application for the introduction of manual transmission components in cars and to test the feasibility of applications to support learning based on Markerless Augmented Reality. This application development method used SDLC or System Development Life Cycle software. The SDLC model that used in this study was the Waterfall model. SDLC consists of the planning, analysis, design, implementation, testing and maintenance. This reaction produced an AR application of Manual Car Transmission which contains material on the introduction of car manual transmission components. Testing applications included blackbox, media and material feasibility, and user response testing. The blackbox testing result got 100 %. The media feasibility analysis show that the assessment of media experts was 87,5 %, material expert 94,4 %, and user response was 85,47 %. From that the AR learning media application manual transmission of cars is categorized as “feasible” to be used as learning media applications.
Implementasi Penetration Testing Execution Standard Untuk Uji Penetrasi Pada Layanan Single Sign-On
Authors: Sunaringtyas Septia Ulfa , Prayoga Djodi Surya
Published: June 2022

Increasing the use of single sign-on technology by electronic-based service providers in addition to providing benefits also creates vulnerability. Penetration testing needed to identify vulnerabilities and test system security by exploiting those vulnerabilities. This research implements the Penetration Testing Execution Standard (PTES) for penetration testing of single singn-on services. Seven stages of the penetration test had done and 12 vulnerabilities were identified, consisting of 3 medium vulnerabilities, 6 low vulnerabilities and 3 information vulnerabilities. Six cyberattacks have been carried out to exploit the vulnerability with the result of 3 successful attacks and 3 failed attacks. Based on the results of the vulnerability and exploitation analysis, recommendations are given consist of regular updating and patching efforts, configuration of the CSP header and content-type-option header on the web server and application server, validation of the host header configuration, x-content-type-options header and deactivation. x-forwarded- hosted on every web page, configure 'secure' flag on cookies, add metacharacter filter feature in source code, and limit login attempts. The results of the PTES’s implementation are proven to make it easier for testers to carry out penetration tests and effectively prevent disputes between testers and clients due to differences in the scope of testing.
Aplikasi Penghitung Jarak dan Jumlah Orang Berbasis YOLO Sebagai Protokol Kesehatan Covid-19
Authors: Indaryanto Faizal , Nugroho Anan , Suni Alfa Faridh
Published: June 2022

Pandemi Covid-19 saat ini cukup memberikan dampak pada masyarakat. Skala penyebaran dari Covid-19 sangatlah cepat, sehingga membutuhkan penanganan yang benar.  Salah satu cara untuk mengurangi penyebaran Covid-19 adalah dengan melakukan Social Distancing. Namun masyarakat cenderung lalai dalam melaksanakan protokol kesehatan tersebut.  Salah satu cara untuk mengatasi masalah ini adalah dengan aplikasi social distancing detector yaitu aplikasi yang digunakan untuk mendeteksi jumlah dan jarak dari objek manusia yang ada pada satu area. Penelitian ini bertujuan untuk mengembangkan aplikasi social distancing detector menggunakan bahasa pemrograman Python dengan library YOLOv3. YOLOv3 memiliki kelebihan dalam object detection dengan akurasi yang tinggi yaitu diatas 90%. Pengujian metode pada penelitian ini menggunakan lima dataset pejalan kaki dari kamera pengawas jalan yang didapatkan dari dataset uji coba beberapa peneliti melalui Github yang memiliki resolusi yang baik dan memiliki objek manusia yang heterogen. Hasil akurasi dari deteksi citra pertama adalah 83,32%. Hasil akurasi dari deteksi citra kedua adalah 76,92%. Hasil akurasi dari deteksi citra ketiga adalah 89,99%. Hasil akurasi dari deteksi citra keempat dan kelima adalah 100%. Hasil Rata-rata tingkat keberhasilan dari semua hasil analisa adalah 90,04% yang diukur dari rata-rata perbandingan jumlah data percobaan berhasil dan jumlah data pengamatan untuk tiap-tiap citra.
Integrating the Concept of Plane Figure and Baduy Local Wisdom as a Media Alternative of Mathematics Learning In Elementary Schools
Authors: Arisetyawan Andika , Taher Tarmizi , Fauzi Irfan
Published: June 2022

This study aims to develop a learning media product that contains the local wisdom of the Baduy tribe. The method used in this research is an ethnographic study to collect data about the Baduy tribe buildings that contain geometric elements. After the data was collected, the researcher used the instructional design research method in the form of the ADDIE model with the aim of making learning media by integrating the local wisdom of the Baduy Tribe in learning geometry based on previous ethnographic studies. The subjects in this study were the Baduy people, teachers, and grade 4 students of one of the elementary schools in Serang City. The results of this study indicate that learning geometry by integrating the local wisdom of the Baduy tribe is very effective in the learning process, so that the learning media product in the form of geomatics cards that are made is ready to be used and implemented in the concept of the plane figure in elementary schools. This research is expected to contribute to education, especially in creating effective learning by integrating culture in mathematics learning in elementary schools.Penelitian ini bertujuan untuk mengembangkan sebuah produk media pembelajaran yang memuat kearifan lokal suku Baduy. Metode yang digunakan dalam penelitian ini adalah studi etnografi untuk mengumpulkan data-data tentang bangunan suku Baduy yang memuat unsur geometri. Setelah data terkumpul, peneliti menggunakan metode instructional design research berupa model ADDIE dengan tujuan untuk membuat media pembelajaran dengan mengintegrasikan kearifan local Suku Baduy pada pembelajaran geometri berdasarkan kajian etnografi sebelumnya. Subjek dalam penelitian ini adalah masyarakat Suku Baduy, guru dan siswa kelas 4 salah satu sekolah dasar di Kota Serang. Hasil penelitian ini menunjukkan bahwa pembelajaran geometri dengan mengintegrasikan kearifan local Suku Baduy sangat efektif diterapkan dalam proses pembelajaran, sehingga produk media pembelajaran berupa kartu geomatika yang dibuat telah siap digunakan dan diimplementasikan padaÂ  konsep bangun datar di sekolah dasar. Penelitian ini diharapkan dapat memberikan kontribusi dalam dunia pendidikan khususnya dalam menciptakan pembelajaran yang efektif dengan mengintegrasikan budaya pada pembelajaran matematika di sekolah dasar.
Development of Measurement Tool for Understanding, Application, and Reasoning Mathematics of Madrasah Ibtidaiyah Students
Authors: Ismail Ilyas , Nursalam Nursalam , Angriani Andi Dian , Kusumayanti Andi
Published: June 2022

This study aims to develop a measurement tool for students' understanding, application and mathematical reasoning ability at Madrasah Ibtidaiyah in South Sulawesi. This research is a formative research type of Research and Development (RD) research through 4 (four) stages, namely: the preliminary stage; the stage of self evaluation (curriculum analysis, material, students) and design; prototyping stage (validation, evaluation and revision) which includes expert reviews, one-to-one and small groups; and the feld test stage. The product of this research was an assessment instrument in the form of questions that measured the ability of understanding, application, and mathematical reasoning of Madrasah Ibtidaiyah students. The test subjects in this study were fourth grade MI students in Makassar City, Gowa regency, and Sinjai regency. The results of the content validity based on the rater indicated that the test items needed were declared valid after being assessed by the rater and analyzed using the CVR (Content Validity Ratio) and CVI (Content Validity Index). In the reliability test, the results of the analysis conducted for multiple choice questions and the contents were in the category of "high" which means that the measurement tools for comprehension, application, and reasoning were indicated to be reliable.Penelitian ini bertujuan untuk mengembangkan alat ukur kemampuan pemahaman, apÂ­likasi, dan penalaran matematika siswa pada Madrasah Ibtidaiyah di Sulawesi Selatan. Penelitian ini merupakan jenis penelitian Research and Development (R D) tipe formative reÂ­search melalui 4 (empat) tahap yaitu: tahap preliminary; tahap self evaluation (analisis kurikuÂ­lum, materi, siswa) dan design; tahap prototyping (validasi, evaluasi dan revisi) yang meliÂ­puti expert reviews, one-to-one dan small group; dan tahap feld test (uji coba lapangan). Produk penelitian ini adalah instrument penilaian berupa soal-soal yang akan mengukur kemamÂ­puan pemahaman, aplikasi, dan penalaran matematika siswa Madrasah Ibtidaiyah. Subjek uji coba pada penelitian ini adalah siswa kelas IV MI di Kota Makassar, Kab. Gowa, dan Kab. Sinjai. Hasil validitas isi (Content validity) berdasarkan rater menunjukkan bahwa butir-butir tes yang dibut dinyatakan valid setelah dinilai oleh rater dan dianalisis dengan menggunakan CVR (Content Validity Rasio) dan CVI (Content Validity Indeks). Pada uji reliabiliÂ­tas, alat ukur kemampuan pemahaman, aplikasi, dan penalaran dikatakan reliabel.
Development of Arithmetic Rows and Series Learning Media in Malay Islam Context
Authors: Saputrama Rendi , Fitrianti Yuli , Ramury Feli
Published: June 2022

This study aims to produce computer-based mathematics learning media using the Adobe Animate CC application on arithmetic sequences and series material in the context of Malay Islam with valid and prismatic categories. This type of research is design research in the development study section of the Akker method with the Tessmer procedure which consists of a preliminary stage and a prototyping stage with a formative evaluation flow (self-evaluation, one-to-one, small group, and field test stages). The research subjects were students of class XI MA Aulia Cendekia Palembang. The results show that the learning media developed is valid and practical.Penelitian ini bertujuan untuk menghasilkan media pembelajaran matematika berbasis komputer menggunakan aplikasi Adobe Animate CC pada materi barisan dan deret aritmetika dalam konteks Islam Melayu dengan kategori valid dan priaktis. Jenis penelitian ini adalah design research pada bagian development study metode Akker dengan prosedur Tessmer yang terdiri dari tahap preliminary dan tahap prototyping dengan alur formative evaluation (tahap selft evaluation, one-to-one, small group, dan field test). Subjek penelitian adalah siswa kelas XI MA Aulia Cendekia Palembang. Hasil menunjukkan bahwa media pembelajaran yang dikembangkan valid dan praktis.