bluuebunny/crossref_metadata_2025 huggingface dataset:
Site-Selective Superassembly of Biomimetic Nanorobots Enabling Deep
Penetration into Tumor with Stiff Stroma
Authors: Yan Miao , Chen Qing , Liu Tianyi , Li Xiaofeng , Pei Peng , Zhou Lei , Zhou Shan , Zhang Runhao , Liang Kang , Dong Jian , Wei Xunbin , Wang Jinqiang , Terasaki Osamu , Chen Pu , Gu Zhen , Jiang Li-Bo , Kong Biao
Published: January 2023

Chemotherapy remains as the first-choice treatment option for triple-negative breast cancer (TNBC). However, the limited tumor penetration and low cellular internalization efficiency of current nanocarrier-based systems impede the access of anticancer drugs to TNBC with dense stroma and thereby greatly restricts clinical therapeutic efficacy, especially for TNBC bone metastasis. In this work, biomimetic head/hollow tail nanorobots were designed through a site-selective superassembly strategy. We show that nanorobots enable efficient remodeling of the dense tumor stromal microenvironments (TSM) for deep tumor penetration. Furthermore, the self-movement ability and spiky head markedly promote interfacial cellular uptake efficacy, transvascular extravasation, and intratumoral penetration. These nanorobots, which integrate deep tumor penetration, active cellular internalization, near-infrared (NIR) light-responsive release, and photothermal therapy capacities into a single nanodevice efficiently suppress tumor growth in a bone metastasis female mice model of TNBC and also demonstrate potent antitumor efficacy in three different subcutaneous tumor models.
Model-Independent Quantum Phases Classifier
Authors: Mahlow Felipe Rodrigues Perche , Luiz Fabrício Souza , Malvezzi André Luiz , Fanchini Felipe Fernandes
Published: January 2023

Machine learning has transformed science and technology. In this article, we present a model-independent classifier that uses the k-Nearest Neighbors algorithm to classify phases of a model for which it has never been trained. This is done by studying three different spin-1 chains with some common phases: the XXZ chains with uniaxial single-ion-type anisotropy, the bond alternating XXZ chains, and the bilinear biquadratic chain. We show that the algorithm trained with two of these models can, with high probability, determine phases common to the third one. This is the first step towards a universal classifier, where an algorithm can recognize an arbitrary phase without knowing the Hamiltonian, since it knows only partial information about the quantum state.
Green Synthesis of ZnO Coated Porous Activated Carbon Prepared from Pontederia crassipe Leaves for the Adsorptive Removal of Toxic Organic Dyes
Authors: Allah Mahmood A. Albo Hay , Alshamsi Hassan A.
Published: January 2023

In the current study, new zinc oxide/activated carbon (ZnO/AC) nanocomposites were successfully synthesized, using Pontederia crassipes leaves as a carbon source for synthesis of activated carbon. In addition, the extract of Pontederia crassipes leaves was obtained as reducing and capping agent in the synthesis of ZnO. The synthesized materials were investigated using various characterization techniques including XRD, FTIR, FE-SEM, EDX, BET-BJH, TEM and Raman, which proved the successful synthesis. The synthesized samples were applied as new nanoadsorbents for the uptake of Malachite Green (MG) and Congo Red (CR) dyes from aquatic media. The thermodynamic, adsorption isotherm and kinetic studies were conducted adopting the batch experiment method. The results showed that the optimum efficiency of removal of both dyes was achieved with ZnO/AC (10%) nanocomposite, which was found to be 98.87% for CR dye and 99.23% for MG dye. The thermodynamic analysis exhibited that adsorption process for both dyes is spontaneous. In addition, the results exhibited that the removal of CR onto ZnO/AC(10%) was exothermic, while that of MG was an endothermic. In the case of adsorption isotherms, the Freundlich model showed the best fit for both dyes with a high correlation coefficient (R2) of 0.99, suggesting heterogeneous surface of the synthesized nanoparticles. The kinetic analysis indicated that both dyes followed a pseudo-second-order kinetic model.
Designing a multifunctional packaging system based on gelatin/alove vera gel film containing of rosemary essential oil and common poppy anthocyanins
Authors: Bakhshizadeh Milad , Ayaseh Ali , Hamishehkar Hamed , Kafil Hossein Samadi , Moghaddam Tina Niknazar , Haghi Parya Baghban , Tavassoli Milad , Amjadi Sajed
Published: January 2023

In this study, an intelligent and active gelatin-based film incorporated with aloe vera gel (AVG), rosemary essential oil (REO), and common poppy (CP) anthocyanins was produced, and its ability to monitor fish freshness was investigated. The film samples were examined by Fourier transforms infrared (FT-IR), field emission scanning electron microscope, and X-ray diffraction tests. The results showed that adding AVG and REO caused the creation of a uniform surface morphology for film samples. Additionally, the FT-IR spectroscopy indicated the formation of new interactions between the gelatin matrix and additives. The addition of CP anthocyanins significantly improved the crystalline structure and mechanical properties of the gelatin-based films. Moreover, the film incorporated with CP anthocyanins showed considerable sensitivity against pH changes and, ammonia gas and their color changed from reddish to green by increasing pH from 2 to 12. In addition, the gelatin/AVG/REO film containing CP anthocyanins was used for monitoring fish spoilage. The obtained results showed that the color of the intelligent colorimetric film changed from red to green, and its SRGB increased to 39.28 % after 72 h storage. These findings indicated the potential of the developed multifunctional film for use in monitoring the spoilage of food products and extending their shelf life.
Investigation of technophobia level and its related factors among nursing students
Authors: Toni Elham , Dehghan Mahlagha , Bagheri Fatemeh , Khajouei Reza
Published: January 2023

Background
Various technologies aid nurses in patient care. However, nurses are often anxious to use these technologies. Despite the adverse effects of nurses' technophobia on patient care, no study has evaluated technophobia in nursing students. This study aimed to investigate the level of technophobia and its causative factors in nursing students.
Methods
This study was performed on nursing students at Kerman University of Medical Sciences (KUMS), Kerman, Iran, using four valid and reliable questionnaires developed based on the existing literature. Independent t-test, analysis of variance, Kruskal-Wallis, and Dunnett T3 post hoc test were used to study technophobia based on background characteristics. The Spearman correlation coefficient was also used to examine the relationship between technological skills and technophobia.
Results
The technophobia rate of nursing students was 33.18 ± 6.95. The level of technophobia was high in the females and students that had lower education (p < 0.05). Nursing students' skills in using information systems and medical equipment were less than their computer skills. Students with low computer skills had a high level of technophobia (p < 0.05). Nurses' technophobia often occurs due to insufficient knowledge, poor experience and skills, and lack of a mentor when using technologies.
Conclusions
The level of technophobia was moderate among nursing students. Their skills to use medical information systems and equipment are less than their computer skills. Low computer skills and poor ability to use medical equipment and information systems increase technophobia. The results suggest improving the computer and technological skills of nursing students especially females from the beginning of their study.
Idiopathic Bullous Pyoderma Gangrenosum in a 12-Year-Old Native American Male: A Case Report and Literature Review
Authors: O'Connor Hunter A. , Veldman Amber , Galloway Carl S.
Published: January 2023

Background:
Pyoderma gangrenosum (PG) is a rare autoinflammatory skin disorder that presents with extremely painful ulcerative skin lesions. Bullous PG is a rare subtype, characterized by formation of large hemorrhagic bullae. The bullous subtype is especially uncommon in children. We present here a case of bullous PG in a young Native American male.
Case Presentation:
A 12-year-old previously healthy Native American male initially developed several pustules on his back and axilla. Over the following three days, the lesions expanded into large hemorrhagic bullae. Suspecting an infectious etiology, he was initially treated with oral and topical antibiotics. The lesions continued to grow in size and number, and some developed into deep ulcerations. Antibiotic coverage was broadened, and he was admitted to a local hospital. The lesions progressed to include all four extremities, the torso, and deep ulcerations of the bilateral axillae. He was transferred to a higher-level facility for further workup. The diagnosis of bullous pyoderma gangrenosum was then made based on histologic findings of neutrophilic infiltration of the dermis and negative workup for other conditions. He was initially treated with systemic corticosteroids with immediate improvement. He continued to experience extreme pain, necessitating PICU admission for sedation during dressing changes. After three weeks, the lesions had healed significantly. He was given an infusion of Infliximab and discharged home. Two months after discharge, healing was nearly complete, and he was again infused with Infliximab. 4.5 months after discharge, his lesions had completely healed, albeit with significant scarring.
Conclusions:
To our knowledge, less than 10 cases of pediatric bullous pyoderma gangrenosum have been reported. Additionally, we are not aware of any other reported cases of bullous PG occurring in a Native American child. PG is often associated with systemic diseases such as inflammatory bowel disease, and hematologic malignancy but no underlying systemic condition was ever found in the current case. As shown in this case, PG is often mistaken for infection, which can delay diagnosis and increase long term morbidity.
Optimization of fermentation conditions for surfactin production by B. subtilis YPS-32
Authors: Zhou Yingjun , Yang Xiaoxue , li qing , Peng Zheng , Li Jianghua , Zhang Juan
Published: January 2023

BACKGROUND
Surfactin produced by microbial fermentation has attracted increasing attention because of its low toxicity and excellent antibacterial activity. However, its application is greatly limited by high production costs and low yield. Therefore, it is important to produce surfactin efficiently while reducing the cost. In this study, B. subtilis strain YPS-32 was used as a fermentative strain for the production of surfactin, and the medium and culture conditions for the fermentation of B. subtilis YPS-32 for surfactin production were optimized.
RESULTS
First, Landy 1 medium was screened as the basal medium for surfactin production by B. subtilis strain YPS-32. Then, using single-factor optimization, the optimal carbon source for surfactin production by B. subtilis YPS-32 strain was determined to be molasses, nitrogen sources were glutamic acid and soybean meal, and inorganic salts were KCl, K2HPO4, MgSO4, and Fe2(SO4)3. Subsequently, using Plackett-Burman design, MgSO4, time (h) and temperature (°C) were identified as the main effect factors. Finally, Box-Behnken design were performed on the main effect factors to obtain optimal fermentation conditions: temperature of 42.9°C, time of 42.8 h, MgSO4 = 0.4 g·L− 1. This modified Landy medium was predicted to be an optimal fermentation medium: molasses 20 g·L− 1, glutamic acid 15 g·L− 1, soybean meal 4.5 g·L− 1, KCl 0.375 g·L− 1, K2HPO4 0.5 g·L− 1, Fe2(SO4)3 1.725 mg·L− 1, MgSO4 0.4 g·L− 1. Using the optimized medium, the yield of surfactin reached 1.82 g·L− 1 at pH 5.0, 42.9℃, and 2% inoculum for 42.8 h, which was 2.27-fold higher than before optimization. Additionally, under these optimal process conditions, further fermentation was carried out at the 5 L fermenter level by foam reflux method, and at 42.8 h of fermentation, surfactin reached a maximum yield of 2.39 g·L− 1, which was 2.96-fold higher than before optimization.
Conclusion
In this study, the fermentation process of surfactin production by B. subtilis YPS-32 was improved by using a combination of single-factor tests and response surface methodology for test optimization, which laid the foundation for its industrial development and application.
Comparison between spectral-domain optical coherence tomography-based and partial coherence interferometry-based biometry
Authors: Ahn So Min , Kim Young Ho , Yun Cheolmin , Oh Jaeryung
Published: January 2023

We compared axial length (AL) measurements using spectral-domain optical coherence tomography (SD-OCT)-based and partial coherence interferometry (PCI)-based biometry in eyes with various chorioretinal diseases. Medical records were retrospectively analyzed in 123 eyes from 73 patients who underwent AL measurements using SD-OCT and PCI. AL values were highly consistent by both measurements (ICC = 0.996 in SD-OCT and 0.995 in PCI-based biometry). The mean difference in AL between the two instruments was − 0.09 ± 0.17 mm, which was significant (P < 0.001). There was a strong correlation between the measurements obtained using the two instruments (r = 0.982, P < 0.001). The 95% limits of agreement were − 0.43 to 0.25 mm, and the agreement of AL in the Bland–Altman analysis showed a difference. The difference in measurements was not associated with the difference in central retinal thickness (r = 0.033, P = 0.720). However, the presence of an epiretinal membrane affected the difference in measurements, unlike in other chorioretinal diseases (P = 0.014). SD-OCT-based biometry showed a good correlation with PCI-based biometry in the measurement of AL; however, the mean AL between the two instruments was significantly different. Therefore, AL measurements made using SD-OCT-based and PCI-based biometry are not interchangeable. The presence of an epiretinal membrane influenced the differences in the measurements.
Impact of Mangrove on Tidal Propagation in a Tropical Coastal Lagoon
Authors: SEUJIP Marcellin SAMOU , BERTIN Xavier , SAKHO Issa , DIOUF Mouhamadou Bachir
Published: January 2023

Very complex aquatic ecosystem, the mangrove forest colonizes coastal lagoons, estuaries and deltas in tropical and subtropical zones. This study investigates the impact of mangrove vegetation on tidal propagation in the Somone Coastal Lagoon, located on the Senegalese small coast. The analysis of new field data is complemented with the application of a 3D circulation model accounting for vegetation. The analysis of well-reproduced water levels and currents over the whole lagoon make it possible to spatially study the amplitudes of the main tidal harmonics, semi-diurnal (M2), diurnal (K1) and the major overtide (M4). The comparison between our baseline model accounting for vegetation and a configuration without vegetation reveals firstly that the mangrove strongly attenuates tidal propagation in the lagoon, whit a stronger impact on semi-diurnal waves than diurnal waves. Tidal currents are also strongly reduced when the mangrove is accounted for, even close to the inlet mouth, far away from vegetation areas. The mangrove also enhances tidal asymmetry and promotes ebb dominance, both in terms of duration (ebbs last from 0.5 up to 3 h more than floods) and current magnitude (ebb currents are about 50% stronger). Spring tides accentuate ebb-dominance compared to neap tides, where tidal asymmetry is weaker.
Changes in seed hydration memory expression through different seasons in a Seasonally Dry Tropical Forest
Authors: Lima Ayslan Trindade , Meiado Marcos Vinicius
Published: January 2023

In Seasonally Dry Tropical Forests, seeds are naturally submitted to hydration and dehydration cycles (HD cycles) during germination process, which can promote the seed hydration memory expression. We investigated how seeds from the same population produced and dispersed in different seasons of the year express seed hydration memory under water deficit conditions after discontinuous hydration, at different hydration times. We collected seeds produced during the dry season and dispersed at the beginning of the rainy season and seeds produced during the rainy season and dispersed at the beginning of the dry season. Seeds were submitted to 0, 1, 2 and 3 HD cycles with different hydration times and placed to germinate under ideal conditions. After verifying that the hydration time between cycles did not influence germination response of the studied species, seeds collected in both seasons of the year were submitted to 0, 1, 2 and 3 HD cycles and placed to germinate at different osmotic potentials (0.0, -0.1, -0.3, -0.6 and -0.9 MPa). After evaluating the germinal parameters, we observed that (1) seeds from the same population, produced and dispersed in different seasons, express seed hydration memory in a different way during their germination process and (2) discontinuous hydration confers greater acquisition of tolerance to seeds produced during dry season. Such germinal responses to HD cycles characterize the seed hydration memory expression, which is influenced by the environmental conditions present during seed development and post-dispersion, conferring ecological implications on the reproductive success of the species.
Salvage Value from Deterioration (SVD): A Three-Parameter Weibull Distribution Inventory Model Approach
Authors: Ogundare Oluwabunmi Chidinma , Onoja Anthony
Published: January 2023

Maintaining inventory systems with deteriorating items is one of the major problems in inventory management. This study aimed to develop an inventory model for deteriorating items with a prior focus on stochastic demand, salvage value, and shortages during which partial backlogging occurred. To achieve this, we derived an innovative approach of a single-item inventory model for deteriorating items having a time-dependent deterioration rate that follows a three-parameter Weibull distribution. While the demand pattern follows a negative exponential distribution with partial backlogging and salvage value. In a real market situation, salvage value is crucial to minimize the cost of the seller on deteriorating items. To validate our model on a real market inventory problem that incurred deteriorating items, we collected numerical data from the Ose poultry store and used the Maple mathematical software package to analyze the situation. An analytical procedure for deriving the optimal inventory solutions was provided. In addition, the necessary and sufficient conditions for the optimal policy of the inventory model were confirmed. A sensitivity analysis of the optimal solution concerning various parameters of the model was carried out to evaluate the model's responsiveness to changes in the inventory parameters. The findings from our study showed that the optimal inventory policy is best achieved when the seller places an order for 50 crates of eggs approximately every 2 weeks. In conclusion, this study can be adapted to complex situations, especially during the phase of the COVID-19 pandemic when supply chains and inventories experienced risks of disruptions.
Obesity and hyperandrogenism are implicated with anxiety, depression and food cravings in women with polycystic ovary syndrome.
Authors: Karagiannakis Dimitrios S , Stefanaki Katerina , Raftopoulou Marina , Psaltopoulou Theodora , Paschou Stavroula A , Ilias Ioannis
Published: January 2023

Introduction

PCOS has been associated with mood and eating disorders. Negative body image due to obesity, acne, hirsutism seems to be implicated, but hormonal derangements may also play a significant role.

Aim

To address the relationship of PCOS with mood and eating disturbances and investigate the latter’s potential association with obesity and hyperandrogenism.

Methods

Eighty-one patients, 49(60.5%) with PCOS and 32(39.5%) age- and BMI-matched healthy controls were enrolled. Emotional and food disorders were assessed by using self-administered questionnaires: Eating Attitudes Test (EAT)-26, Beck Depression Inventory-II (BDI-II), Hamilton anxiety scale (HAS) and Food Craving Questionnaire-Trait (FCQ-T).

Results

The two groups had no significant differences regarding age, BMI and HOMA2-IR. PCOS women had significantly higher DHEA-S (p<0.0001), Δ4Α (p<0.0001) and Testosterone (p<0.0001). When the two groups were subclassified according to the BMI, in lean (BMI<25kg/m2) or overweight (BMI≥25kg/m2), no significant differences were found in respect to EAT-26 and HAS. BDI-II was associated with obesity (overweight vs lean PCOS:18 vs 16.5;p=0.037) and hyperandrogenism (overweight PCOS vs overweight controls: 18vs13; p<0.0001; lean PCOS vs overweight controls: 16.5vs13; p=0.01), while a significant correlation with DHEA-S (r=0.305;p=0.006), Δ4Α (r=0.259;p=0.02) and Testosterone (r=0.328;p=0.003) was reported. FCQ-T was associated with obesity (overweight PCOS vs lean PCOS: 53vs28.5; p<0.0001; overweight controls vs lean PCOS: 40vs28.5; p<0.0001), whereas a correlation with BMI (r=0.593;p=0.0001), waist circumference (r=0.554;p=0.0001) and HOMA2-IR (r=0.328;p=0.003) was documented.

Conclusions

Obesity, insulin resistance and hyperandrogenism increase the risk of depression and food cravings in PCOS, leading to a vicious circle of further aggravation of obesity and metabolic syndrome.
A New Complex Number Definition: Distinct Imaginary Numbers
Authors: Pakdemirli Mehmet
Published: January 2023

A new base complex number is defined. To distinguish it from the usual complex number i, the name “distinct imaginary number” is proposed with a shorter referral of “dimaginary number” and symbol j. The complex number with this new base included can be referred to as dicomplex numbers (distinct complex numbers) accordingly. Based on the new definition, the basic arithmetic operations are handled first. Taylor series expansions with the new complex number are given next. Application areas such as finding roots of polynomials, analytical geometry in three and higher dimensional spaces are discussed. The new definition extends the usual two-dimensional complex plane into three and higher dimensional spaces.
Prediction of Public Opinion through Real-Time Monitoring
using Multimodal Recurrent Neural Network
Authors:   Edeh Michael Onyema1, Gupta Shashi Kant , Limka Suresh , Hossain Ismail , Ray Samrat , Voumik Liton Chandra
Published: January 2023

There is growing use of technology and presence of people online globally. Electronic platforms have also become the avenue for expression of opinions on emerging issues by people. However, some of the posts or comments posted online could sometimes be negative with far reaching effects on the community. The use of machine learning algorithms through sentiment analysis offers means that could be used to mine data and analyse opinions that emanate from online to reach decisions or monitor ethical compliance. This study presents an approach that uses a Multimodal fusion with Recurrent Neural Networks (M-RNN) to predict opinions through decision making and real time monitoring. The dataset was trained using standard methods like a decision tree classifier, and the M-RNN model achieved an accuracy of roughly 82.80%. The training model's relative average error was close to 0.503% when using the M-RNN methodology, and the training cycle only needs to be repeated 250 times to achieve satisfactory results, a figure that is low when compared to other conventional methods.
Manifestação Oral Atípica pelo HPV Diagnosticado em Paciente com Síndrome da Imunodeficiência Adquirida e Múltiplos Fatores de Risco: Relato de Caso
Authors: Flamini Filho Renato , Brazão Carlos Gabriel Barbosa , Sales Bisneta Maria de Lourdes Cabral de , Alecrim Mary Elsa , Freire Milton César , Cabral Lioney Nobre
Published: January 2023

O Vírus da Imunodeficiência Humana, quando associado à uma terapia antirretroviral deficiente ou ao abandono do esquema terapêutico, é o responsável pelo desenvolvimento da Síndrome da Imunodeficiência Adquirida, quadro clínico de imunossupressão que predispõe o paciente ao aparecimento de infecções oportunistas. A infecção pelo Vírus do Papiloma Humano é uma das infecções oportunistas mais comuns e diversos fatores de risco podem estar associados à sua prevalência, dentre eles o tabagismo e etilismo, que também contribuem para a persistência da infecção e possível cancerização de lesões causadas pelo vírus. O presente estudo tem como objetivo relatar o caso clínico de um paciente do sexo masculino, ex-tabagista, ex-etilista, ex-usuário de drogas com diagnostico tardio do Vírus da Imunodeficiência Humana e em quadro de Síndrome da Imunodeficiência Adquirida, que apresentou leucoplasias em bordo bilateral de língua. Foi necessária exérese total das lesões e a análise histopatológica apresentou características de infecção pelo Vírus do Papiloma Humano, além de displasia atípica com alta replicação viral e possibilidade de malignidade.
TYPES OF FEEDBACK USED BY THE STUDENTS IN INTERMEDIATE WRITING CLASS
Authors: Alamsyah Hendra , Listia Rina , Mu'in Fatchul
Published: January 2023

Writing is the most complicated skill among other language skills. In the writing activity, the students have to invent ideas and organize them into sentences and paragraphs that will be clear for readers. Feedback is crucial to give significant improvement to student's writings. Peers and maybe various can provide feedback. This study's objective was to describe the types of feedback used by students of the Intermediate Writing Class in writing an argumentative paragraph. Descriptive qualitative was the design of research. The subjects of this research are A1 and A4 Intermediate Writing course students of the English language Education Study Program of Lambung Mangkurat University. The data were collected through observation and document analysis. The data were then analyzed through three steps: familiarizing and organizing, coding, and interpreting and representing. The result was found that the students used several feedback types, namely written feedback as responding and written feedback as correcting. Written feedback as correcting used by the students consists of direct feedback, metalinguistic feedback, and unfocused feedback. From some of the metalinguistic feedback that some students used, they were using the grammatical description. Some of the metalinguistic feedback that some students used was the metalinguistic explanation (grammatical description). There was no metalinguistic feedback of the error code. There was only one student who used unfocused feedback. In conclusion, the students used four feedback types: written feedback as responding, written feedback as correcting, or written corrective feedback consisting of direct feedback, metalinguistic feedback, and unfocused feedback. Written feedback as responding is the feedback that the students used most while doing peer feedback. The students need to look for more information and explanation or feedback from the teachers and their friends and give feedback while doing peer feedback properly to not only use one type of feedback.
EXPLORING THE PRESERVICE TEACHERS’PERCEPTION TOWARD THE USE OF DUOLINGO IN TEACHING VOCABULARY TO YOUNG LEARNERS
Authors: Herminingsih Dwi Ima
Published: January 2023

The purpose of doing research is to have the investigation on the students’ belief when Duo lingo application is applied in the class of vocabulary and to describe the justification of the advantages using the Duo lingo to empower the vocabulary enrichment. The students of English Study Program in State Islamic College as Pre Service –teachers have participated in this study. The data were collected by the questionnaire distribution and the interview methods. The data analysis uses the qualitative description. The result of the study exposes the facts that the respondents agree the Duo lingo can facilitate the vocabulary learning achievement. The medium labelled Duo lingo makes the students easy and interesting in learning the English word knowledge. The interview with the sample of informants suggests the testimony that the young learners can use the app overtime as far as they want. They are free to set or make up the schedule of lesson session. One more meaningful thing found in the application is that the English is spoken by the native speaker. By performing the English of the native speaker can be a model or master for the students.  They get the chance to exercise repeating the word or the sentence spoken by the native speaker correctly.
Influence of the canal width and depth on the resistance of 750 DWT Perintis ship using CFD simulation
Authors:   Department of Naval Architecture, Universitas Diponegoro, Semarang 50275, Indonesia, Hadi Eko Sasmito , Tuswan Tuswan , Azizah Ghina , Ali Baharuddin ,   Research Center for Hydrodynamics Technology, National Research and Innovation Agency (BRIN), Surabaya 60117, Indonesia, Samuel Samuel , Hakim Muhammad Luqman , Hadi Muhammad Raaflie Caesar Putra , Iqbal Muhammad ,   Department of Naval Architecture, Ocean, and Marine Engineering, University of Strathclyde, Glasgow, UK, Sari Dian Purnama , Satrio Dendy ,   Department of Ocean Engineering, Institut Teknologi Sepuluh Nopember, Surabaya 60111, Indonesia
Published: January 2023

Investigation of hydrodynamic interaction between the vessel and the seabed when entering shallow water is considered one of the most critical considerations of inland waterway transport. There are many investigations into the behavior of ships in restricted waters, such as ships traveling in different forms of canal cross-sections. The present study aims to evaluate the hydrodynamic interaction of the 750 DWT Perintis Ship moving through the different canal types to determine the relative effects of limiting the width and depth cross section on the ship's resistance. Two different canals with different cross sections, including canal bank and rectangular canal, were evaluated to investigate the influence of canal width (Wb), depth ratio (hw/T), and blockage ratio function (As/Ac). The Computational Fluid Dynamic (CFD) method with Reynolds-averaged Navier–Stokes (RANS) solver and turbulent model 𝑘−𝜀 were used to predict the total resistance of the ship. The proposed numerical simulation was initially validated with an experimental towing tank test in the error range of 0.11-7.74%. The results indicated similar phenomena were found both in rectangular and canal banks. The case with a shallower (lower hw/T) and a narrower (lower Bc/Bs) canal dimension has a higher resistance value. Backflow and subsidence of free surface became significant around the ship's hull in more restricted water, changing the ship's hydrodynamic characteristics and increasing resistance. It can be found that the higher the blockage ratio (mb), the higher the total resistance value in both canal types, which proved that ships with higher speeds were more sensitive to changes in waterway restrictions.
Pengajaran Nilai Moral dalam Perspektif PPKN
Authors: Yunhadi Wuwuh
Published: January 2023

This study gives expression to the correlation of value of moral to civics education achievement. Chi-Square was used to analyze the data. The findings of the study were revealed that a significant correlation was proven by value of moral (X) to civics education achievement (Y) with the Chi Square coefficient  = 46.09 that was greater (>) than -table 9.49 at the significance level 0.05 and df = 4.  It meant that the more teaching of value of moral was good, the civics education achievement became more and more raising, too.
COD REMOVAL FROM MUNICIPAL WASTEWATER USING ELECTROCOAGULATION BY DIFFERENT AL/FE ELECTRODES
Authors:   Professor, MVPSS, KBT College of Engineering, Nashik, Department of Civil Engineering, Savitribai Phule Pune University, Pune, Maharashtra, India., Nemade P.D. , Patil R.N. ,   Faculty, Pimpri Chinchwad Education Trusts Pimpri Chinchwad College of Engineering, Pune, Department of First Year Engineering, Savitribai Phule Pune University, Pune, Maharashtra, India., Tambe Y.H. ,   Faculty, Vidya Pratishthans Kamalnayan Bajaj Institute of Engineering and Technology, Baramati, Pune, Department of Civil Engineering, Savitribai Phule Pune University, Pune, Maharashtra, India.
Published: January 2023

In the present study different combinations of Al and Fe electrodes are used for improving the treatment efficiency in the electrocoagulation (EC) process to purify the domestic wastewater. Various factors are to be studied for the assessment of the COD removal efficiency in the form of pH (3â€“9), time (10â€“60 min), and density of current (9.0â€“40 A/m2). Depending on the influencing factor Alâ€“Al and Feâ€“Fe able to minimize COD percentage up to 85.0 % and 90% respectively. Similarly 86.0 % and 87.50 % of COD were removed, when aluminium and iron were combined as Alâ€“Fe and Feâ€“Al respectively. Further, the operating parameters were investigated on the removal of COD. The present study reported that, the combination of electrodes affects greatly on the efficiency of percentage removal of COD using the EC technique.
MATERNAL AND FETAL OUTCOME IN EMERGENCY CAESAREAN SECTIONS IN WAD MEDANI OBSTETRICS AND GYNAECOLOGY HOSPITAL GEZIRA STATE-SUDAN
Authors:   Department of Obstetrics and Gynecology Umm Al-Qura University Makkah, Saudi Arabia., Mahdi Ahmed Hassan Albagir
Published: January 2023

Background: Caesarean section is among the commonest performing procedures worldwide. Its rate is steadily increasing, and its indications is expanding despite the increased morbidity and mortality over the vaginal delivery. Objectives: The aim of this is study is to study the maternal and fetal outcome of emergency caesarean section also the study aims to know the indications for the emergency caesarean sections. Methods: A prospective descriptive study conducted in Wad Medani Teaching Hospital in the period June 20th, 2021, to September 20th, 2021, and included 100 patients who had emergency caesarean sections. All data collected about patients was in included in a flow chart and analysed using SPSS (Statistical Package for Social Sciences) results were tabulated and presented in percentage forms. Results: The study revealed that: the rate of Caesarean section in the hospital was 35% of which 63.4% were emergency CS and 46.6% were elective CS, emergency CS was common in the age group 18-34 years (82%). Emergency CS is common in primigravidae ladies (50%). Most common indications of emergency CS were Failure to progress, repeat CS, Hypertension, fetal distress andmalpresentations. Intraoperative maternal complications such as anaestheticcomplications were (23%), haemorrhage (26%). Postoperative maternal complications such as PPH were (14%), Sepsis (12%), wound infection (6%) and VTE (5%). Regarding the neoanatal outcome in regard of APGAR score less than 7 at 5 were (12%) Other neoanatal complications such as RDS (14%), birth asphyxia (7%).
CHANGE IN PSYCHIATRIC SYMPTOMS IN A BIPOLAR PATIENT REVEALING ENDOCRANIAL EXTENSION OF A FRONTAL MUCOCELE
Authors:   Faculty of Medicine And Pharmacy of Oujda (FMPO), Mohamed The First University, Morocco., Nsabi Farah ,   Research For Mental Health, University Psychiatric Hospital, Oujda, Morocco., Jelti Adil ,   Faculty of Medicine And Pharmacy of Oujda (FMPO), Mohamed The First University, Morocco.,   Research For Mental Health, University Psychiatric Hospital, Oujda, Morocco., Oneib Bouchra ,   Faculty of Medicine And Pharmacy of Oujda (FMPO), Mohamed The First University, Morocco.,   Research For Mental Health, University Psychiatric Hospital, Oujda, Morocco., El Ghazouani Fatima ,   Faculty of Medicine And Pharmacy of Oujda (FMPO), Mohamed The First University, Morocco.,   Research For Mental Health, University Psychiatric Hospital, Oujda, Morocco.
Published: January 2023

Mucoceles are benign tumors of the sinuses, caused by obstruction of the sinus ostium. They most often affect the frontal and the ethmoid sinuses.The clinical representation of mucoceles is changeable according to their sizes, their extensions, and the nature of the affected sinus. The diagnosis of a mucocele is based on computed tomography (CT) or even better magnetic resonance imaging. Despite their benign nature, they can be responsible for serious complications that can affect the visual prognosis and require urgent treatment. The clinical case describes a 52-year-old with bipolar disorder, stable under treatment for 10 years. The patient has a right frontal mucosal with intracranial extension compressing the frontal lobe, revealed by the sudden change in the patients psychiatric manifestations. which presents a very rare and atypical entity.
COMPARATIVE ADVERTISEMENT: PROTECTION OR INFRINGEMENT OF THE TRADEMARK
Authors:   Assistant Professor, Vivekananda Institute of Professional Studies, Pitampura, Delhi(Affiliated to Guru Gobind Singh Indraprastha University, Delhi)., Jain Sonia
Published: January 2023

Marketing the product has been seen as one of the most strategic developments in the industry. Now the product, along with the quality, needs excellent and representable marketing to attract the customer. People are primarily being recruited and appointed to look after the same. But for selling the product in the market, are the producer crossing the line of competition and the rights of Intellectual property nowadays? In the present article, an attempt has been made to discuss comparative advertising and why trademarks should be protected to promote goods in the market. The discussion between the same highlights the public policy to protect the consumer interest at large. Comparative advertising and trademark protection embark on the fair competition for consumer welfare.
EFFECT OFVARIATIONSIN ABCC2, CYP2C9, CYP2C19 & SCN2A GENESON TREATMENT RESPONSETO ANTICONVULSANTS- A SYSTEMATIC REVIEWAND META-ANALYSIS OF GENETIC ASSOCIATION STUDIES
Authors:   Doctor of Pharmacy, KrupanidiCollege of Pharmacy, Bengaluru - 560035., Loukya Mamillapally , Zeneth B. Defria ,   Doctor of Pharmacy, KrupanidiCollege of Pharmacy, Bengaluru - 560035., Gideon George P. Samuel ,   Assistant Professor,Department of Pharmacy Practice, Krupanidhi College of PharmacyBengaluru - 560035.
Published: January 2023

Objective: This study was aimed to determine the effect of genetic polymorphisms (non-synonymous, missense, and copy number variations) in ABCC2, CYP2C9, CYP2C19&SCN2A genes on treatment response to anticonvulsants. Methods: The search was carried out in PubMed, Scopus, Cochrane Central Register of Controlled Trials, Embase, LILACS, Google Scholar, MEDLINE, ScienceDirect, Web of Science, and the DOAJ database. Hardy Weinberg Equilibrium (HWE), New-Castle Ottawa scale value, Cochrane Review Manager 5.0 (&R 4.0.3,) and Rayyan QCRI are used for assessing data synthesis, risk of bias, heterogeneity assessment using I[2]statistics and calculating Inter-rater agreement respectively. Publication bias assessment was performed using Eggers test and the Funnel plot. For statistical analysis, random effects modeling was used to explain the association between genetic variations in ABCC2, CYP2C9, CYP2C19 & SCN2A genes related to drug resistance or treatment failure. Results: This meta-analysis includes a total of 29 studies. We found a greater risk of AED resistance in ABCC2rs2273697 genetic variations (OR=1.51 [ 0.93-2.47], p value=0.03 at 95% CI), ABCC2 rs3740066 genetic variation has a greater possibility of AED resistance was seen in pooled population (OR= 0.85 [0.12-5.85], p-value<0.01 at 95% CI), risk of drug resistance was increased by ABCC2 rs717620 polymorphism. (OR =2.13, [1.02-4.44], p-value<0.01 at 95% CI), CYP2C9 rs1799853 polymorphism had a significant increase in AED resistance (OR =1.27, [0.49-3.32] p-value<0.01 at 95% CI), CYP2C9 rs1057910 polymorphism. (OR= 0.74, [0.32-1.70] p-value 0.01 at 95% CI), CYP2C19 rs4244285 polymorphism. (OR= 0.68, [0.29-1.62], p value=0.02 at 95% CI), SCN2A rs2304016 polymorphism. (OR= 1.20, [0.48-3.05], p value<0.01 at 95% CI), SCN2Ars17183814 polymorphism. (OR =1.51, [1.12-2.03], p value=0.30 at 95% CI). Conclusions:Gene polymorphisms play a key role in epilepsy development and therapeutic efficacy, and could have greater impact treatment outcomes.
ANALYSIS OF A DRILLING HYBRID ALUMINUM METAL MATRIX COMPOSITES BY USING SPSS
Authors:   Department of Mechanical Engineering, KBN College of Engineering Kalaburagi, Karnataka India., a Nayeemuddin , Salma Umme ,   Department of Mechanical Engineering, KBN College of Engineering Kalaburagi, Karnataka India.
Published: January 2023

Hybrid Metal matrix composites are light weight and high strength Applications include aerospace and automobile industry Advanced materials are used. Mixed Used In preparing metal matrix composites Among various techniques, the stirrup casting technique is the simplest And economical. Aluminum alloy alloys are new The generation is metal matrix composites, which The latest requirements of advanced engineering applications have the ability to fulfill Aluminum matrix composites (AMCs) are light weight high of efficient aluminum core material systems represent a class. Reinforcement in AMCs is Continuous/discontinuous filaments, whiskers or A few percent to 70% is in particulate form. Aluminum Metal matrix composites (AlMMCs) are Light Weight, high stiffness and moderate strength applications Successful in meeting stringent specifications It is a category of proven products. Required Properties. MMCs are metal as a reinforcing material is formed by dispersion in the matrix. Reinforcement To prevent a chemical reaction with the matrix The surface can be coated. For example, in aluminum matrix Carbon fibers with low density and high strength are commonly used. to consolidate composites. Matrix Materials and Major Compounds: Several metals in groups are used. Aluminum, Titanium, Magnesium and Copper alloys are very important and Super alloys. Fine particles: Silicon Carbide, Boron Carbide, Titanium Carbide.
A CASE STUDY ON AYURVEDIC MANAGEMENT OF CEREBRAL PALSY
Authors:   Associate Professor, PG Department of Kaumarbhritya, Shri Krishna Government Ayurvedic College and Hospital, Kurukshetra, India., Kataria Amit , Kaur Jaspreet ,   MD Scholar, PG Department of Kaumarbhritya, Shri Krishna Government Ayurvedic College and Hospital, Kurukshetra, India.
Published: January 2023

Cerebral Palsy (CP) is defined as a non-progressive neuromotor disorder of cerebral origin. Approximately 1-2 per 100 live births is a reasonable estimate of incidence. A 11 years female child was diagnosed with CP. She was treated with modern treatment from 19.6.2012 to 3.3.2018. She was given Ayurvedic medications and treated convincingly by oral medication, local application and procedures. The medication and the procedures reduced the Vata Dosha and acted as Pushtivardhaka that improved the overall condition of the patient.
CORRELATIONAL STUDY OF NEUTROPHIL-TO LYMPHOCYTE RATIO AND BIOMARKERS (IL-6, CRP, ESR, FERRITIN) WITH COVID-19 SEVERITY
Authors:   Third Year Student, MD Pathology, Department of Pathology, School of Medical Sciences & Research, Sharda University, Greater Noida., Gill Gurleen , Gupta Devra Anshu ,   Professor& Head, Department of Pathology, School of Medical Sciences & Research, Sharda University, Greater Noida., Sharma Swati ,   Assistant Professor, Department of Pathology, School of Medical Sciences & Research, Sharda University, Greater Noida., Punia VPS ,   Professor & Head, Department of Medicine, School of Medical Sciences & Research, Sharda University, Greater Noida., Bindra MS ,   Professor, Department of Pathology, Noida International Institute of Medial Sciences, Noida., Gupta Shubhangi ,   Associate Professor, Subharti Medical College, Swami Vivekanand Subharti University, Meerut.
Published: January 2023

Background: India is 5th worst hit nation by COVID-19 with 5.2 lacs deaths attributable to the disease. To counteract this global tragedy, many research articles have highlighted the role of various haematological and inflammatory biomarkers in assessing the severity of the disease. Materials and Methods: A retrospective analysis of 100 RT-PCR confirmed COVID-19 patients was undertaken. The patients were initially categorised into mild, moderate, and severe categories based on SpO2 levels & clinical symptoms at the time of admission. The blood sample was analysed for haematological and inflammatory biomarkers including NLR, IL-6, CRP, ESR and Serum ferritin. The data obtained was compared between severe and non-severe (mild+moderate) categories. Results: On correlating NLR with disease severity, patients with non-severe disease had a mean of 3.7 whereas it was 6.7 in the severe group, signaling that patient with severe disease had significantly high NLR compared to non-severe patients. The inflammatory markers studied, ESR, CRP & Serum ferritin- all three of them showed markedly increased mean values in severe patients. However, in our study, IL-6 levels were not found to correlate with severity of COVID-19. On performing ANOVA t test, NLR, ESR and serum ferritin were found to be significantly correlated with disease severity (p-value<0.05) but no significant correlation was found with IL-6. Conclusions: Our study highlights the importance of taking into consideration the values of NLR, ESR, CRP and serum ferritin as a screening tool at the time of initial presentation of COVID-19 patients to triage those requiring intensive care for optimum utilisation of limited resources.
ERADICATION OF DEVADASI SYSTEM IN SOUTH INDIA
Authors:   Assistant Professor & Research Convener., Anilkumar P. ,   P.G & Research Department of History.,   Iqbal College, Peringammala, Thiruvananthapuram, Kerala.
Published: January 2023

The devadasi system became popular custom in South India. It means a woman who performed the service to the Gods in the temple. In sangam literature, the dancing woman and prostitutes are frequently mentioned. Sethu Lekshmi Bai, the Queen Regent of Travancore abolished the system in1930.
IMPACT OF E-LEARNING ON PEDIATRIC LIFESTYLE DURING COVID-19 PANDEMIC
Authors:   Dr. Sulaiman Al Habib Medical Group., Shakas M. Al Ghamdi Talal , Abdullah Al Batil Khawlah ,   KSMC Family Medicine Academy., Atiyah Alatiyah Forat ,   KSMC Family Medicine Academy., Mohedeen Aldawalibi Ahmad ,   KSMC Family Medicine Academy., Khalid Al Duraywish Abdulmajeed ,   KSMC Family Medicine Academy., Ali Al Mardhamah Abdulmohsen ,   KSMC Family Medicine Academy.
Published: January 2023

Background: Coronavirus 2019 (COVID-19) affects our lifestyle globally, especially while the lockdown. E-learning becomes essential worldwide to limit the pandemic. In this circumstance children tend to spend more time using the Internet for studying purposes and entertainment, Subsequently, the prevalence of obesity increased from 8.9% to 11.5% (10). Furthermore, a study was accomplished in Switzerland.75 percent of children, and up to 100 percent of adolescents have a tendency to utilize screen time, throughout detention, and the proportion of children who engage in less than two hours of light physical activity each day has doubled (3). There are insufficient studies performed in Saudi Arabia so we endeavored to decline the negative impact of E-learning on childrens lifestyles. Methodology: A community-based cross-sectional study will be conducted from December 2021 to February 2022 in the Kingdom of Saudi Arabia at primary healthcare centers. The data will be entered into an Excel sheet and analyzed by SPSS. Results: A total of 857 participants were included in the current study. Physical activity decreased among 453 (52.9%) and increased among 201 (23.5%). 720 (84%) reported changes in sleep habits during the pandemic, and 346 (40.4%) reported sleep disturbance. Conclusion: The COVID-19 pandemic had a significant impact on the learning and lifestyle of children. It resulted in the tendency and increase in E-learning and an increase in physical activity and eating habits. This can be considered a positive impact on childrens learning and behavior.