bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrative perspective of the healthy aging process considering the metabolome, cardiac autonomic modulation and cardiorespiratory fitness evaluated in age groups
Authors: De Favari Signini Étore , Castro Alex , Rehder-Santos Patrícia , Cristina Millan-Mattos Juliana , Magalhães de Oliveira Juliana , Minatel Vinicius , Bianca Falasco Pantoni Camila , Sobreiro Selistre de Araújo Heloisa , Fabrizzi Fernando , Porta Alberto , Gilberto Ferreira Antônio , Vincenzi Oliveira Regina , Maria Catai Aparecida
Published: December 2022

The aging process causes changes at all organic levels. Although metabolism, cardiac autonomic modulation (CAM), and cardiorespiratory fitness (CRF) are widely studied as a function of age, they are mainly studied in isolation, thus making it difficult to perceive their concomitant variations. This study aimed to investigate the integrated changes that occur in the metabolome, CAM, and CRF throughout aging in apparently healthy individuals. The subjects (n = 118) were divided into five groups according to age (20–29, 30–39, 40–49, 50–59, and 60–70 years old) and underwent blood collection, autonomic assessment, and a cardiopulmonary exercise test for metabolomics analysis using mass spectrometry and nuclear magnetic resonance, cardiac autonomic modulation analysis, and CRF by peak oxygen consumption analysis, respectively. The Tukey’s post hoc and effect size with confidence interval were used for variables with a significant one-way ANOVA effect (P < 0.01). The main changes were in the oldest age group, where the CRF, valine, leucine, isoleucine, 3-hydroxyisobutyrate, and CAM reduced and hippuric acid increased. The results suggest significant changes in the metabolome, CAM, and CRF after the age of sixty as a consequence of aging impairments, but with some changes in the metabolic profile that may be favorable to mitigate the aging deleterious effects.
Associations of cardiorespiratory fitness, body composition, and blood pressure with arterial stiffness in adolescent, young adult, and middle-aged women
Authors: Haapala Eero A. , Lee Earric , Karppinen Jari , Skog Hannamari , Valtonen Maarit , Kujala Urho M. , Laukkanen Jari A. , Ihalainen Johanna K. , Laakkonen Eija K.
Published: December 2022

Few studies have investigated whether higher cardiorespiratory fitness (CRF) or favourable body composition are related to lower arterial stiffness in women. We therefore investigated the associations of CRF, body fat percentage (BF%), fat free mass index (FFMI), and mean arterial pressure (MAP) with arterial stiffness in 146 women aged 16–58 years. CRF was assessed by a maximal exercise test with respiratory gas analysis either on a cycle ergometer or a treadmill. Aortic pulse wave velocity (PWVao), augmentation index (AIx%), and MAP were assessed by a non-invasive oscillometric device and BF% and FFMI by a bioelectrical impedance or DXA device. CRF was inversely associated with PWVao (β =  − 0.004, 95% CI − 0.005 to − 0.002) and AIx% (β =  − 0.075, 95% CI − 0.102 to − 0.048) and these associations remained similar after adjustment for BF% or MAP, but not after the adjustment for age. FFMI was inversely associated with PWVao (β =  − 0.010, 95% CI − 0.019 to − 0.002) and MAP directly associated with PWVao (β = 0.005, 95% CI 0.003 to 0.006) and AIx% (β = 0.092, 95% CI 0.069 to 0.116) and the associations with PWVao also remained after further adjustments for BF% and age. In conclusion, a higher FFMI and a lower MAP were independently associated with lower arterial stiffness.
Directional touch sensing for stiffness singularity search in an object using microfinger with tactile sensor
Authors: Konishi Satoshi , Kakehi Yugo , Hori Yuto
Published: December 2022

Palpation is widely used as the initial medical diagnosis. Integration of micro tactile sensors and artificial muscles enables a soft microfinger for active touch sensing using its bending actuation. Active touch sensing by pushing-in motion of microfinger enables to evaluate stiffness distribution on an elastic object. Due to its compactness, the microfinger can enter a narrow space, such as gastrointestinal and abdominal spaces in a body. However, a microfinger can only touch and sense limited points. We aim at efficient method for searching a stiffness singular part in an elastic object by the directional touch sensing of a microfinger. This study presents a microfinger for active touch sensing using bending and push-in actuation and proposes an algorithm utilizing directivity in touch sensing by a microfinger for efficient localization of the stiffness singular part in an object. A gelatin block structure with a small rigid ball was prepared and touch sensed by the microfinger. Consequently, the position of the buried rigid ball could be efficiently identified based on the proposed algorithm. This result implies that the proposed method has potential applications in endoscopic medical diagnosis, particularly in identifying tumor positions.
Comparison of inspiratory and expiratory airway volumes and luminal areas among standing, sitting, and supine positions using upright and conventional CT
Authors: Yamada Yoshitake , Yamada Minoru , Chubachi Shotaro , Yokoyama Yoichi , Matsuoka Shiho , Tanabe Akiko , Niijima Yuki , Murata Mitsuru , Abe Takayuki , Fukunaga Koichi , Jinzaki Masahiro
Published: December 2022

Upright computed tomography (CT) provides physiologically relevant images of daily life postures (sitting and standing). The volume of the human airway in sitting or standing positions remains unclear, and no clinical study to date has compared the inspiratory and expiratory airway volumes and luminal areas among standing, sitting, and supine positions. In this prospective study, 100 asymptomatic volunteers underwent both upright (sitting and standing positions) and conventional (supine position) CT during inspiration and expiration breath-holds and the pulmonary function test (PFT) within 2 h of CT. We compared the inspiratory/expiratory airway volumes and luminal areas on CT among the three positions and evaluated the correlation between airway volumes in each position on CT and PFT measurements. The inspiratory and expiratory airway volumes were significantly higher in the sitting and standing positions than in the supine position (inspiratory, 4.6% and 2.5% increase, respectively; expiratory, 14.9% and 13.4% increase, respectively; all P < 0.001). The inspiratory and expiratory luminal areas of the trachea, bilateral main bronchi, and average third-generation airway were significantly higher in the sitting and standing positions than in the supine position (inspiratory, 4.2‒10.3% increases, all P < 0.001; expiratory, 6.4‒12.8% increases, all P < 0.0001). These results could provide important clues regarding the pathogenesis of orthopnea. Spearman’s correlation coefficients between the inspiratory airway volume on CT and forced vital capacity and forced expiratory volume in 1 s on PFT were numerically higher in the standing position than in the supine position (0.673 vs. 0.659 and 0.669 vs. 0.643, respectively); however, no statistically significant differences were found. Thus, the airway volumes on upright and conventional supine CT were moderately correlated with the PFT measurements.
Developing a diagnosis model for dry eye disease in dogs using object detection
Authors: Kim Joon Young , Han Myeong Gyun , Chun Jae Heon , Huh Eun A. , Lee Suk Jun
Published: December 2022

The purpose of this study was to develop an object detection method for the diagnosis of dry eye disease (DED) in dogs. To this end, a methodology was designed to evaluate ocular surface video images using the YOLOv5 model, which is an object detection algorithm that has been widely used because of its simple network structure and fast detection speed. Because the cornea is a transparent organ, an illuminator plate with grid squares was used to provide grid lines, which were analyzed as the reflected straight lines of the light source representing the precorneal tear film (PTF) stability. The original video consisted of the number of 12 normal images(normal, $$n$$
n
= 17) and the number of 15 abnormal images(abnormal, $$n$$
n
= 17), converted to JPEG images for labeling, learning, and model validation. The labeled image data were divided into a training image data set (normal, $$n$$
n
= 15,276; abnormal, $$n$$
n
= 26,196) to a validation image data set (normal, $$n$$
n
= 6546; abnormal, $$n$$
n
= 11,228). As a result of the experiment, the mean average precision ($$mAP$$

mAP

) achieved 0.995. This study proposes a method to effectively determine ocular surface status in dogs by using YOLOv5 and concludes that an object detection model can be used in the veterinary field.
Evaluation of a quantitative PCR-based method for chimerism analysis of Japanese donor/recipient pairs
Authors: Minakawa Keiji , Ono Satoshi , Watanabe Mao , Sato Yuka , Suzuki Saki , Odawara Shou , Kawabata Kinuyo , Ueda Koki , Nollet Kenneth E. , Sano Hideki , Ikezoe Takayuki , Kikuta Atsushi , Ikeda Kazuhiko
Published: December 2022

Chimerism analysis is a surrogate indicator of graft rejection or relapse after allogeneic hematopoietic stem cell transplantation (HSCT). Although short tandem repeat PCR (STR-PCR) is the usual method, limited sensitivity and technical variability are matters of concern. Quantitative PCR-based methods to detect single nucleotide polymorphisms (SNP-qPCR) are more sensitive, but their informativity and quantitative accuracy are highly variable. For accurate and sensitive chimerism analysis, a set of KMR kits (GenDx, Utrecht, Netherlands), based on detection of insertions/deletions (indels) by qPCR, have been developed. Here, we investigated informativity and validated the accuracy of KMR kits in Japanese donor/recipient pairs and virtual samples of DNA mixtures representative of Japanese genetic diversity. We found that at least one recipient-specific marker among 39 KMR-kit markers was informative in all of 65 Japanese donor/recipient pairs. Moreover, the percentage of recipient chimerism estimated by KMRtrack correlated well with ratios of mixed DNA in virtual samples and with the percentage of chimerism in HSCT recipients estimated by STR-PCR/in-house SNP-qPCR. Moreover, KMRtrack showed better sensitivity with high specificity when compared to STR-PCR to detect recipient chimerism. Chimerism analysis with KMR kits can be a standardized, sensitive, and highly informative method to evaluate the graft status of HSCT recipients.
Reduced heart rate variability and expressive suppression interact to prospectively predict COVID-19 pandemic-related post-traumatic stress symptoms
Authors: Dell’Acqua Carola , Mura Francesca , Messerotti Benvenuti Simone , Patron Elisabetta , Palomba Daniela
Published: December 2022

The COVID-19 pandemic is a unique period of stress that, in some cases, led to post-traumatic stress symptoms (PTSSs). Emotion regulation strategies are known to modulate the emotional response to stressful events. Expressive suppression (ES) is a maladaptive strategy related to the exacerbation of the physiological stress response. Heart rate variability (HRV), an index of cardiac autonomic balance strictly related to ES, was also shown to predict PTSSs. This was the first study to investigate whether the pre-pandemic ES use and resting-state HRV predicted pandemic-related PTSSs. Before the pandemic, 83 (58 females) university students completed the Emotion Regulation Questionnaire (ERQ), self-report measures of anxiety and depressive symptoms, and a three-minute resting-state electrocardiogram recording. After 12 months, 61 (45 females) participants completed a self-report measure of pandemic-related PTSSs and repeated the self-report psychological measures. Pre-pandemic anxiety symptoms prospectively predicted greater PTSSs. Moreover, a significant interaction between HRV and ES in predicting PTSSs emerged, whereby those who had higher levels of ES and reduced HRV showed higher PTSSs. These findings suggest that an integrated assessment of HRV and ES might be useful for identifying individuals who are more vulnerable to the development of PTSSs during crises.
Phenolic composition of ten plants species used as ethnoveterinary medicines in Omusati and Kunene regions of Namibia
Authors: Eiki N. , Manyelo T. G. , Hassan Z. M. , Lebelo S. L. , Sebola N. A. , Sakong B. , Mabelebele M.
Published: December 2022

The therapeutic benefits of phenolic compounds found in plants are well known. The purpose of this study was to determine the phenolic content of ten plant species used as ethnoveterinary treatments in Namibia’s Omusati and Kunene regions. The plants of concern were Aloe esculenta, Fockea angustifolia, Boscia albitrunca, Combretum imberbe, Acacia nilotica, Colophospermum mopane, Acacia erioloba, Ziziphus mucronata, Ximenia americana, and Salvadora persica. An LC–MS approach was used to identify the compounds. To analyse high-resolution UPLC-UV/MS, a Waters Acquity ultra-performance liquid chromatograph (UPLC) with a photodiode array detector was connected to a Waters Synapt G2 quadrupole time-of-flight mass spectrometer (MS). The current study identified a total of 29 phenolic compounds. Flavonoids (epicatechin, (-)-Epigallocatechin, and rutin,) were the most abundant, followed by 2R, 3S-Piscidic acid. Methylisocitric acid was found in all species investigated, with the highest quantities in A. esculenta and X. americana leaf extracts. There were differences in composition and quantity of phenolic compounds in aerial and ground sections between species. The overall findings of the present study would act as a standard for subsequent investigations into the pharmacological potentials of plants species utilized as ethnoveterinary remedies. Priority should be given to isolating, purifying, and defining the active compounds responsible for these plants' activity.
Tract-based white matter hyperintensity patterns in patients with systemic lupus erythematosus using an unsupervised machine learning approach
Authors: Rumetshofer Theodor , Inglese Francesca , de Bresser Jeroen , Mannfolk Peter , Strandberg Olof , Jönsen Andreas , Bengtsson Anders , Nilsson Markus , Knutsson Linda , Lätt Jimmy , Steup-Beekman Gerda M. , Huizinga Tom W. J. , van Buchem Mark A. , Ronen Itamar , Sundgren Pia C.
Published: December 2022

Currently, little is known about the spatial distribution of white matter hyperintensities (WMH) in the brain of patients with Systemic Lupus erythematosus (SLE). Previous lesion markers, such as number and volume, ignore the strategic location of WMH. The goal of this work was to develop a fully-automated method to identify predominant patterns of WMH across WM tracts based on cluster analysis. A total of 221 SLE patients with and without neuropsychiatric symptoms from two different sites were included in this study. WMH segmentations and lesion locations were acquired automatically. Cluster analysis was performed on the WMH distribution in 20 WM tracts. Our pipeline identified five distinct clusters with predominant involvement of the forceps major, forceps minor, as well as right and left anterior thalamic radiations and the right inferior fronto-occipital fasciculus. The patterns of the affected WM tracts were consistent over the SLE subtypes and sites. Our approach revealed distinct and robust tract-based WMH patterns within SLE patients. This method could provide a basis, to link the location of WMH with clinical symptoms. Furthermore, it could be used for other diseases characterized by presence of WMH to investigate both the clinical relevance of WMH and underlying pathomechanism in the brain.
Quantum chemistry of the excited state: advances in 2020–2021
Authors: Cuéllar-Zuquin Juliana , Carmona-García Javier , Navarrete-Miguel Miriam , Cerdán Luis , Francés-Monerris Antonio , Giussani Angelo , Segarra-Martí Javier , Roca-Sanjuán Daniel
Published: December 2022

Research on excited-state chemistry using multiconfigurational quantum chemistry (MQC) allows deep analyses of the involved electronic-structure transformations. Overview of the published bibliography in the 2020 and 2021 period shows predominant MQC research on biomedicine and materials science. Significant work on method developments has been also carried out, and applications in atmospheric chemistry are gaining interest as compared to previous years. Topics that are representative of the progress, and are revised herein, are methodology developments for more realistic predictions of UV/Vis absorption and emission spectra, sunlight chemistry on atmospheric modelling, DNA photostability and photosensitisation, DNA reactivity by ionising radiation, chemiluminescence and self-illuminating photosensitisation, DNA repair mechanisms and quantum computing applications in photochemistry.
Organic aspects: functions containing a heteroatom different from oxygen (2020–2021)
Authors: Benazzi Valentina , Crespi Stefano , Protti Stefano
Published: December 2022

In this chapter we review the main photochemical reactions of chromophores containing nitrogen, boron, halogen atoms, phosphorus and sulfur reported in the 2020–2021 period. It should be noted that only the reactions where such chromophores are responsible for the direct absorption of light have been considered. Thus, processes occurring by means of photocatalysts/photosensitizers able to activate such chromophores are not the focus of this chapter.
Photochemistry electrified: pushing the boundaries of radical-based organic synthesis
Authors: Jorea Alexandra , Dell'Amico Luca , Goti Giulio , Ravelli Davide
Published: December 2022

The successful merging of photochemical and electrochemical strategies has recently opened new avenues in synthesis endeavours, offering unique possibilities for the generation and manipulation of radical intermediates. This chapter offers an overview about recent contributions in the field, classifying the available examples according to the operating mechanism, which may involve either a homogeneous photocatalytic cycle or a different photoinduced event. In terms of synthetic applications, the merger of photochemistry and electrochemistry enables to realize a plethora of arylation processes of both aromatic and aliphatic fragments, oxidations, as well as the forging of C–heteroatom bonds.
Photocatalytic modifications of benzamides
Authors: Giedyk Maciej , Kamińska Agnieszka
Published: December 2022

Benzamide derivatives are highly prevalent in biologically active compounds, including approved and investigational drugs of diverse mechanism of action. They have also been exploited as radiotracers for melanoma imaging and as chromophores for stereochemical studies by circular dichroism. Such a wide range of applications of benzamides makes late-stage modification of their structure a vibrant area of research. In this chapter, we review the state of the art in photocatalytic modifications of benzamides at their N-alkyl fragments. The protocols developed so far include such transformations as intramolecular cyclisation, annulation, intermolecular C–H arylation, alkylation and N-dehalogenation processes. We also indicate probable directions for further development in this area of research.
Transient absorption spectroscopy in visible-light photocatalysis
Authors: Swords W. B. , Yoon T. P.
Published: December 2022

Over the past two decades, photocatalytic synthesis has emerged as a major theme of research within synthetic organic chemistry. This recent surge of interest has been motivated by the uniquely facile access offered by photocatalysis to high-energy reactive intermediates such as open-shell radicals and electronically excited states. The high reactivity of these intermediates enables the development of transformative new reactions, but their characteristically short lifetimes present a challenge for studying the mechanisms of these reactions. Transient absorption (TA) spectroscopy offers a powerful tool that can provide insight into the identity of photocatalytically generated intermediates, the kinetics of their elementary steps, and the participation of competitive unproductive processes. While this technique has only recently been applied to the interrogation of complex synthetic reactions, the extension of this tool into the investigation of photocatalytic mechanisms has provided insights that are not readily available using any other technique. This chapter introduces the principles of transient absorption spectroscopy and presents four case studies that highlight its use in the study of photocatalytic reactions. These studies demonstrate that TA spectroscopy provides insights that are complementary to those available using the conventional tools of physical organic chemistry.
Correction: Chemo-photodynamic combined gene therapy and dual-modal cancer imaging achieved by pH-responsive alginate/chitosan multilayer-modified magnetic mesoporous silica nanocomposites
Authors: Yang Hong , Chen Yin , Chen Zhongyuan , Geng Yue , Xie Xiaoxue , Shen Xue , Li Tingting , Li Shun , Wu Chunhui , Liu Yiyao
Published: December 2022

Correction for ‘Chemo-photodynamic combined gene therapy and dual-modal cancer imaging achieved by pH-responsive alginate/chitosan multilayer-modified magnetic mesoporous silica nanocomposites’ by Hong Yang et al., Biomater. Sci., 2017, 5, 1001–1013, https://doi.org/10.1039/c7bm00043j.
A chemoenzymatic strategy for the efficient synthesis of amphenicol antibiotic chloramphenicol mediated by an engineered l-threonine transaldolase with high activity and stereoselectivity
Authors: Xu Lian , Nie Dan , Su Bing-Mei , Xu Xin-Qi , Lin Juan
Published: December 2022

Chemo-enzymatic route for chloramphenicol.
Transcriptomic and metabolomic analyses provide insights into the attenuation of neuroinflammation by nervonic acid in MPTP-stimulated PD model mice
Authors: Wang Xueqi , Zhu Xinliang , Li Xu , Li Zhengdou , Mao Ying , Zhang Shunbin , Liu Xiaoxiao , Liu Xingguo , Liu Yapeng , Cao Fuliang , Zhang Ji
Published: December 2022

Nervonic acid is one of the most promising bioactive fatty acids, which is believed to be beneficial for the recovery of human cognitive disorders.
The preventive effect of Chinese sumac fruit against monosodium urate-induced gouty arthritis in rats by regulating several inflammatory pathways
Authors: Ma Nan , Zhang Yuanyue , Wang Tao , Sun Yilin , Cai Shengbao
Published: December 2022

Chinese sumac (Rhus chinensisMill.) fruit is a traditional Chinese medicinal material that can effectively prevent gouty arthritis in rats.
Large-scale controlled coupling of single-photon emitters to high-index dielectric nanoantennas by AFM nanoxerography
Authors: Humbert Mélodie , Hernandez Romain , Mallet Nicolas , Larrieu Guilhem , Larrey Vincent , Fournel Frank , Guérin François , Palleau Etienne , Paillard Vincent , Cuche Aurélien , Ressier Laurence
Published: December 2022

Large-scale coupling of nanodiamonds hosting NV centers to silicon dimer nanoantennas was achieved by AFM nanoxerography. This controlled process, yielding configurations down to a single deposited quantum emitter, leads to their enhanced brightness.
Toward eco-friendly protocols: insights into direct arylation polymerizations under aerobic conditions in anisole
Authors: Carlucci Claudia , Conelli Daniele , Hassan Omar Omar , Margiotta Nicola , Grisorio Roberto , Suranna Gian Paolo
Published: December 2022

The viability of direct arylation polymerizations in anisole under aerobic and undried conditions is proved in the case of the paradigmatic polymers, which are obtained with high molecular weights and structural regularity by using a “green” protocol.
A fluorescent aptasensor based on gold nanoparticles quenching the fluorescence of rhodamine B to detect acetamiprid
Authors: Yu Yuyan , Ye Shumin , Sun Zhiwen , You Jinkun , Li Weili , Song Yu , Zhang Hongyan
Published: December 2022

In this paper, we present a turn-on fluorescent approach to detect acetamiprid in traditional Chinese medicine, with a high sensitivity and low detection limit. It provides more application possibilities for fluorescence-aptamer biosensing.
The electronic, magnetic, and optical properties of double perovskite La2BB′O6 (B = Cr, V and B′ = Co, Ni and Sc)
Authors: Arif Suneela , Ali Yasir
Published: December 2022

Total density of states (TDOS) of La2CrCoO6 (LCCO), La2CrNiO6 (LCNO), La2ScNiO6 (LSNO), La2VNiO6 (LVNO) and La2VScO6 (LVSO) compounds calculated by the GGA scheme.
Preparation of ecofriendly water-borne polyurethane elastomer with mechanical robustness and self-healable ability based on multi-dynamic interactions
Authors: Shi Qingsong , Wu Weilin , Yu Bing , Ren Mengqing , Wu Lili , Zhang Chaocan
Published: December 2022

Environmentally friendly WPU with multiple hydrogen bonds and boronic ester bonds within its polymer backbone was synthesized. Benefiting from multiple dynamic interactions, the prepared WPU elastomer exhibited good mechanical properties and desirable self-healing ability.
Polyester-based polyurethanes derived from alcoholysis of polylactide as toughening agents for blends with shape-memory properties
Authors: Eang Chorney , Nim Bunthoeun , Opaprakasit Mantana , Petchsuk Atitsa , Opaprakasit Pakorn
Published: December 2022

A process for sizing down and functionalizing polylactide (PLA) is developed by alcoholysis. These are used as polyols in preparing PLA-based polyurethanes for toughening of brittle PLA. The blends exhibit improved mechanical properties with a high shape recovery efficiency.
Day-to-Day Variability of Clinical Feeding and Swallowing Performance in School-Age Self-Feeding Children With Cerebral Palsy
Authors: Malandraki Georgia A. , Kantarcigil Çagla , Craig Bruce A. , Zhang Yumin , Gordon Andrew M.
Published: December 2022

Purpose:

We aimed to examine the day-to-day variability of feeding and swallowing performance and mealtime duration in school-age self-feeding children with spastic cerebral palsy (SCP) across 15 days.

Method:

Thirteen children with SCP (ages 5;10 [years;months]–17;6) participated. Children were divided into unilateral (UCP,
n
= 6) and bilateral (BCP,
n
= 7) SCP groups. Feeding/swallowing assessments using the Dysphagia Disorder Survey (DDS) were conducted and total mealtime durations (TMDs) were calculated for all days. DDS Part 1 (factors related to feeding) and DDS Part 2 (signs of oropharyngeal difficulties) components were rated. Mixed-effects models were used to compare group means and estimate between- and within-subject variances in each group. Likelihood ratio tests were used to determine best covariance structure and compare variance types across groups.

Results:

Within-subject variance for all three variables, DDS Part 1, 2, and TMD, across days was larger in the BCP group than the UCP group (Part 1:
p
= .0036, Part 2:
p
= .0002, and TMD:
p
= .0005) and the between-subject variance was larger in the BCP group for DDS Part 2 (
p
= .0362). The UCP group presented with lower (milder) DDS scores (Part 1:
p
= .0160; Part 2:
p
= .0141) and shorter TMD
(p
= .0077) than the BCP group across days. Furthermore, both groups exhibited greater variability in DDS Part 2 than 1 (
p
< .0001).

Conclusion:

These preliminary results emphasize the need to account for day-to-day variability when evaluating swallowing especially in children with BCP and provide preliminary ranges of performance that could be useful for clinical prognosis and future treatment research.

Supplemental Material:

https://doi.org/10.23641/asha.21669611
Retracted: Research on wavelet neural network PID control of maglev linear synchronous motor
Authors: Mao Jun , Ma Jun
Published: December 2022

Retraction: [Jun Mao, Jun Ma, Research on wavelet neural network PID control of maglev linear synchronous motor, IET Circuits, Devices & Systems 2022 (https://doi.org/10.1049/cds2.12136)].

The above article from IET Circuits, Devices & Systems, published online on 8 December 2022 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the Editor‐in‐Chief, Harry E. Ruda, the Institution of Engineering and Technology (the IET) and John Wiley and Sons Ltd. This article was published as part of a Guest Edited special issue. Following an investigation, the IET and the journal have determined that the article was not reviewed in line with the journal’s peer review standards and there is evidence that the peer review process of the special issue underwent systematic manipulation. Accordingly, we cannot vouch for the integrity or reliability of the content. As such we have taken the decision to retract the article. The authors have been informed of the decision to retract.
Multi‐parameters dynamic scheduling with energy management for electric vehicle charging stations
Authors: Wang Haodong , Chen Ning , Liu Zan , Zhang Songwei , Li Zhiguo , Qiu Tie
Published: December 2022

To make charging of electric vehicles (EVs) more convenient, the service providers of charging stations (CSs) establish a large number of CSs. Existing methods address the problem of reducing costs and increasing revenue for the service providers from multiple aspects, such as CS location optimisation and charging pricing strategy. This study proposes multi‐parameters‐based‐dynamic scheduling with energy management for the CSs, considering energy management and EV charging scheduling (EVCS). A fully functional battery management system is designed for energy storage. A multi‐parameters optimisation algorithm is proposed by designing the CS selection operator based on alternative set and adjusting parameters. The experiments show that our proposed algorithms got better performance in terms of optimisation effect, the number of iterations, and stability.
MTSCANet: Multi temporal resolution temporal semantic context aggregation network
Authors: Zhang Haiping , Ma Conghao , Yu Dongjin , Guan Liming , Wang Dongjing , Hu Zepeng , Liu Xu
Published: December 2022

Temporal action localisation is a challenging task, and video context is crucial to localisation actions. Most existing cases that incorporate temporal and semantic contexts into video features suffer from single contextual representation and blurred temporal boundaries. In this study, a multi‐temporal resolution pyramid structure model is proposed. Firstly, a temporal‐semantic context aggregation module (TSCF) is designed to assign different attention weights to temporal contexts and combine them with multi‐level semantics into video features. Secondly, for the problem of large differences in the time span between different actions in the video, a local‐global attention module is designed to combine local and global temporal dependencies for each temporal point to obtain a more flexible and robust representation of contextual relations. The redundant representation of the convolution kernel is reduced by modifying the convolution and the arithmetic power is redeployed at a microscopic granularity. To verify the effectiveness of the model, extensive experiments on three challenging datasets are performed. On THUMOS14, the best performance is obtained in IoU@0.3–0.6 with an average mAP of 47.02%. On ActivityNet‐1.3, an average mAP of 34.94% was obtained. On HACS, an average mAP of 28.46% was achieved.
A novel superimposed component‐based protection method for multi‐terminal transmission lines using phaselet transform
Authors: Ansari Sajad , Ghaffarzadeh Navid
Published: December 2022

This paper presents a novel protection method for transmission lines that estimates the superimposed component phasor using phaselet transform. The phaselet transform computes the phasors over variable‐lenfgth data window at the instant of a fault, so it can estimate the phasor less than one full cycle. The presented method phaselets are used to extract the superimposed component instead of the samples and the initial phase angle difference (IPAD) of the superimposed currents between terminals is used to detect internal and external faults. The main contribution of this method is an accurate, fast and robust superimposed component‐based algorithm that uses the phaselet transform to estimate the phasor of the superimposed component for distinguishing internal faults from external faults; this method is also reliable against transients such as current transformer (CT) saturation and capacitor bank switching. To evaluate the performance of the proposed method, a three‐terminal transmission line is modelled in the alternative transients program/electromagnetic transients program (ATP/EMTP) software and several cases including fault and transients are simulated; finally, the data has been analyzed in MATLAB software. The simulation results show that the proposed method is able to quickly and accurately distinguish internal faults from external faults and is not affected by transients.
Palliativmedizin – mehr als eine
Fachdisziplin?
Authors: Kloke Marianne
Published: December 2022

Der Erörterung der besonderen Bedeutung von Palliativmedizin (PM)
für Patienten, die Medizin und die Gesellschaft wird die Frage nach der
Existenz eines eigenständigen Fachgebietes PM vorangestellt. In
Anwendung der von R. Stichweh beschriebenen Kriterien muss diese mit Ja
beantwortet werden. Die Spezifika von PM werden anhand ihres
gesamtgesellschaftlichen Anspruches und Selbstverständnisses sowie ihrer
medizin-ethischen Bedeutung aufgezeigt. Fazit: Die Reintegration des
PM-Gedankens in die gesamte Medizin kann erheblich zur Humanisierung sowohl der
Medizin als auch der Gesellschaft beitragen.
Psychische Gesundheit bei Kindern und Jugendlichen mit rheumatischen Erkrankungen
Authors: Sengler Claudia , Milatz Florian , Minden Kirsten
Published: December 2022

Kinder und Jugendliche mit chronischen rheumatischen Erkrankungen erleben oft vielfältige Belastungen, wie Schmerzen, Funktionsstörungen, Nebenwirkungen von Medikamenten, und sind nicht selten durch zeitintensive Therapien und Arztbesuche in ihrem sozialen Leben beeinträchtigt. So kann – trotz immer besserer Therapiemöglichkeiten – auch die psychische Gesundheit leiden. Verschiedene Forschungsverbünde (z. B. COACH) und Studien (z. B. KickCOVID) widmen sich zurzeit mittels spezifischer Fragebögen psychischen Symptomen von Kindern und Jugendlichen mit verschiedenen chronischen Erkrankungen (z. B. Mukoviszidose, juvenile idiopathische Arthritis, Typ-1-Diabetes). Psychische Komorbiditäten können im Kontext einer chronischen Erkrankung zu einer schlechteren Lebensqualität sowie zu einer geringeren Therapieadhärenz führen, welche wiederum das Outcome der Grunderkrankung beeinträchtigt. Eine umfassende Versorgung chronisch kranker junger Menschen sollte daher ein standardisiertes Screening auf psychische Komorbiditäten im Rahmen routinemäßiger Verlaufskontrollen beinhalten.
Sarkopenie als unabhängiger Prognosefaktor bei Pankreaskarzinom
Authors: Mandl Johanna , Baumer Sebastian , Holtzem Bernadette , Theurer Rainer , Zorger Niels , Pech Oliver
Published: December 2022

Einleitung Die Diagnose Pankreaskarzinom zählt trotz modernster Diagnose- und Therapieoptionen zu den häufigsten krebsbedingten globalen Todesursachen. Häufig liegt bei diesen Patienten eine Kachexie und Sarkopenie vor.

Methode In einer retrospektiven Analyse wurde die jeweilige Querschnittsfläche der Skelettmuskulatur auf Höhe des Lendenwirbelkörpers L 3 im axialen CT-Schnittbild von 121 Patienten bestimmt, um so den Skelettmuskelindex (SMI [cm2/m2]) zu erhalten. Es erfolgte außerdem eine Erfassung weiterer Parameter zur zusätzlichen Evaluation deren Assoziation mit der Überlebenswahrscheinlichkeit.

Ergebnisse Die durchschnittliche Überlebenszeit der Gruppe der sarkopenen Patienten war mit 14,4 Monaten im Vergleich zu 17,7 Monaten mittlerer Überlebenszeit bei Patienten ohne Sarkopenie signifikant vermindert (p=0,046). Zusätzlich konnten das Alter (p = 0,006), eine nicht erfolgte Resektion des Tumors (p=0,004), Metastasen bei Erstdiagnose (p=0,002) sowie ein erhöhtes CA 19–9 (p=0,002) als statistisch signifikante negative Prognosefaktoren identifiziert werden.

Schlussfolgerung Sarkopenie ist ein unabhängiger prognostischer Faktor in Bezug auf die Überlebenszeit bei Pankreaskarzinompatienten. Dies legt die standardmäßige Integration des SMI als Prognoseparameter in den klinischen Alltag nahe, um durch entsprechende präventive und therapeutische ernährungs- und bewegungsmedizinische Maßnahmen möglicherweise die Lebensdauer sowie die Lebensqualität von Pankreaskarzinompatienten merklich verbessern zu können.
Können Resilienz und Selbstwirksamkeit Therapieelemente in der Behandlung chronisch kranker Kinder und Jugendlicher sein?
Authors: Rohde Michelle , Mönkemöller Kirsten
Published: December 2022

Resilienz und Selbstwirksamkeit sind entscheidende Variablen im Therapieerfolg chronisch erkrankter Kinder und Jugendlicher. Resilienzförderliche Faktoren finden sich nicht nur bei der betroffenen Person selbst, sondern vor allem auch in ihrem Umfeld. Dabei sind verlässliche Bezugspersonen ebenso bedeutsam wie ressourcenorientierte Fachkräfte, um Betroffenen eine nach vorne gerichtete Entwicklung zu ermöglichen. Die vorliegende Arbeit zeigt, dass es sinnvoll sein kann, Patienten und ihre Familien auch im Rahmen der Therapie gezielt in der Bewältigung ihrer Erkrankung zu unterstützen und bei ihnen vorhandene Ressourcen zu stärken. Es werden daher Möglichkeiten aufgezeigt, wie resilienz- und selbstwirksamkeitssteigernde Elemente effizient in die Therapie von chronischen Erkrankungen im Kindes- und Jugendalter integriert werden könnten.
Diabetes und Schwangerschaft
Authors: Hummel Michael , Füchtenbusch Martin , Battefeld Wilgard , Bührer Christoph , Groten Tanja , Haak Thomas , Kainer Franz , Kautzky-Willer Alexandra , Lechner Andreas , Meissner Thomas , Nagel-Reuper Christine , Schäfer-Graf Ute , Siegmund Thorsten
Published: December 2022

Schwangerschaften mit präkonzeptionell bekanntem Typ-1- und Typ-2-Diabetes sind Hochrisiko-Schwangerschaften und bedürfen einer interdisziplinären Betreuung. Kinder diabetischer Mütter haben ein im Mittel 1,5- bis 3-fach erhöhtes Risiko für angeborene Fehlbildungen, Frühgeburtlichkeit, Hypertrophie, Atemstörungen, Plexusparese und Asphyxie. Das Risiko für Totgeburt und Tod in den ersten 7 Lebenstagen ist bei prägravidem Diabetes erhöht. Die mit Abstand häufigste Komplikation bei Neugeborenen diabetischer Mütter ist die postnatale Hypoglykämie. Diabetesassoziierte Begleiterkrankungen und maternale Adipositas sind unabhängige Risikofaktoren für Schwangerschaftskomplikationen und ein ungünstiges fetales Outcome. Für die Blutglukoseeinstellung während der Schwangerschaft wurde ein klarer Zusammenhang höherer Werte mit ungünstigen fetalen und maternalen Ereignissen gezeigt. Analoginsuline sind mittlerweile die Insuline der Wahl. Darüber hinaus konnte eine Überlegenheit einer CGM-Versorgung während der Schwangerschaft gegenüber der konventionellen Blutglukosemessung gezeigt werden. Die Rate an Sektiones ist bei Frauen mit Diabetes nach wie vor gegenüber der Grundgesamtheit in der Perinatalstatistik deutlich erhöht. Evidenzbasierte Erkenntnisse zum intrapartalen Vorgehen liegen nicht vor. Die Einstellungsziele orientieren sich daher an den während der Schwangerschaft geltenden Zielen.
A Comparative Review of the Outcome Following MVD and PBC in Patients with Trigeminal Neuralgia
Authors: Zhou Yi , Dou Ning-Ning , Liu Xue-Lai , Wang Hui , Zhong Jun
Published: December 2022

Background This study aims to systematically review the treatment outcomes of percutaneous balloon compression (PBC) and microvascular decompression (MVD) in patients with trigeminal neuralgia.

Methods A systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guideline was performed using PubMed, Embase, and Cochrane Central Registry of Controlled Trials databases. Only those articles with more than 5 years' follow-up length were included in this investigation. To uniformly assess the postoperative outcome, we defined pain relief as totally pain free, while the postoperative hospitalization and last follow-up period were defined as early and long term, respectively. The facial numbness was quantified with Barrow Neurological Institute Pain Intensity Score (BNI).

Results After database searching and screening, 7,797 cases were finally included according to the criteria. The early pain relief rates were 94.1% (1,551/1,649) and 89.9% (4,962/5,482) following PBC and MVD (odds ratio [OR] = 0.603; p < 0.05), while the long-term rates were 58.1% (921/1,566) and 74.9% (4,549/6,074; OR = 2.089; p < 0.05), respectively. Although a significant higher facial numbness occurred in the PBC group in the early stage, it was mostly diminished 5 years later compared with the MVD group. At long-term follow-up, hypoacusis and facial palsy occurred more often in the MVD group (p < 0.05).

Conclusions Both MVD and PBC provide a satisfactory outcome for the patients in the long term. As a simple, safe, and reliable technique, PBC should be considered as a viable alternative.
Comparative Analysis on Surgical Operability and Degree of Exposure of Microsurgical Approaches to Intraforaminal Lumbar Disk Herniations
Authors: Gagliardi Filippo , Pompeo Edoardo , Snider Silvia , Roncelli Francesca , Medone Marzia , De Domenico Pierfrancesco , Piloni Martina , Mortini Pietro
Published: December 2022

Background Intraforaminal lumbar disk herniations (IFDHs) represent a heterogeneous and relatively uncommon disease; their treatment is technically demanding due to the anatomical relationships with nerve roots and vertebral joints. Over time, several approaches have been developed without reaching a consensus about the best treatment strategy.

Materials and methods Authors comparatively analyze surgical operability and exposure in terms of quantitative variables between the different microsurgical approaches to IFDHs, defining the impact of each approach on surgical maneuverability and exposure on specific targets.

A comparative microanatomical laboratory investigation was conducted. The operability score (OS) was applied for quantitative analysis of surgical operability.

Results Transarticular and combined translaminar-trans-pars-interarticularis approaches result in providing the best surgical exposure and maneuverability on all targets with surgical controls on both nerve roots, at the expense of a higher risk of iatrogenic instability. Trans-pars-interarticularis approach reaches comparable levels of operability, even limited to the pure foraminal area (lateral compartment); similar findings were recorded for partial facetectomy on the medial compartment. The contralateral interlaminar approach provides good visualization of the foramen without consensual favorable maneuverability, which should be considered the main drawback.

Conclusions Approach selection has to consider disease location, the possible migration of disk fragments, the degree of nerve root involvement, and risk of iatrogenic instability. According to the findings, authors propose an operative algorithm to tailor the surgical strategy, based both on the precise definition of anatomic boundaries of exposure of each approach and on surgical maneuverability on specific targets.
A Case of Fulminant Listeria Rhombencephalitis with Brainstem Abscesses in a 37-Year-Old Immunocompetent Patient: From Vestibular Neuritis to Ondine's Curse
Authors: Percuoco Veronica , Kemp Oliver , Bolognese Manuel , von Hessling Alexander , Scholte Johannes B.J. , Schneider Ulf C.
Published: December 2022

We present a rare case of Listeria monocytogenes (LM) rhombencephalitis with the formation of multifocal abscesses in a young immunocompetent patient. His initial symptoms of dizziness, headache, and feeling generally unwell were put down to a coincidental coinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The unfortunate rapid progression to trigeminal, hypoglossal, vagal, facial, and abducens nuclei palsies, and then an acquired central hypoventilation syndrome, known as Ondine's curse, required a prolonged intensive care unit (ICU) stay, and prolonged mechanical ventilation. As they continued to deteriorate despite targeted antibiotic treatment, surgical drainage of the abscesses was seen as the only meaningful available treatment option left to contain the disease. Postoperatively, the patient's strength rapidly improved as well as the severity of the cranial nerve palsies. After prolonged rehabilitation, at 3 months of follow-up, the patient was weaned off mechanical ventilation, independently mobile, and was left with only minor residual neurologic deficits. This case highlights a number of interesting findings only touched upon in current literature including the route of entry of LM into the central nervous system, the rare entity of acquired central hypoventilation syndrome, and finally the use of surgical intervention in cerebral LM infections.
Safety and Efficacy of Combined Imbrication Axle Reconstruction and Z-Type Titanium Plate Fixation for Hinge Fracture Displacement During Open-Door Laminoplasty
Authors: Liu Fa-jing , Li Ning , Chai Yi , Ding Xiao-kun , Yang Hai-yun , Li Peng-fei
Published: December 2022

Background Open-door laminoplasty is a classical decompression method used to treat cervical spondylotic myelopathy. However, hinge fracture displacement (HFD) is a common occurrence during this procedure. The current study aimed to investigate the safety and efficacy of a combined imbrication axle reconstruction and Z-type titanium plate fixation method for HFD during open-door laminoplasty.

Methods In total, 617 patients with cervical spondylotic myelopathy who underwent C3–C7 open-door laminoplasty from March 2015 to October 2018 were included in this retrospective study. Overall, 73 patients developed HFD during surgery. Of these, 43 underwent combined imbrication axle reconstruction and Z-type titanium plate fixation (IRZF group) and 30 underwent traditional titanium plate fixation (TF group). Data such as the operative time, intraoperative blood loss volume, and distribution of fractured hinges were recorded. Both groups were compared in terms of improvement in neurologic function, cervical curvature index, hinge fusion rate, incidence of C5 palsy, severity of axial symptoms, and development of complications.

Results The operative time and intraoperative blood loss were slightly higher in the IRZF group than in the TF group; however, the differences were not significant (p > 0.05). Furthermore, there was no significant difference between the groups in terms of the number of fractured segments and the distribution of fractured hinges (p > 0.05). The cervical curvature index did not decline in the two groups (p > 0.05). The IRZF group had a higher hinge fusion rate than the TF group at 3 (79.6 vs. 57.1%) and 12 (93.9 vs. 74.3%) months postoperatively (p < 0.05). There was no significant difference in the incidence of C5 palsy between the two groups (9.3 vs. 6.7%; p > 0.05). However, the TF group had more severe axial symptoms than the IRZF group (p < 0.05). The neurologic function of the two groups increased postoperatively as per the Japanese Orthopaedic Association scoring system (p < 0.05). Nevertheless, there was no significant difference in terms of neurologic function at any observational time point (p > 0.05). One patient in the TF group with hinge nonunion underwent laminectomy due to lamina displacement into the spinal canal and nerve root compression.

Conclusion In patients with HFD, IRZF facilitates a more intimate contact between the lamina and the lateral mass and, therefore, achieves fractured hinge fusion without additional surgical trauma. This technical improvement can significantly promote neurologic recovery, decrease the severity of axial symptoms, and prevent the development of spinal cord or nerve root recompression.