bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplemental spreadsheet for "Evaluation of Canopy Temperature based Crop Water Stress Index for Deficit Irrigation Management of Sugar Beet in Semi-Arid Climate"
Authors: King Bradley , Tarkalson David , Bjorneberg David
Published: February 2024

Use of canopy temperature for deficit irrigation (DI) scheduling of sugar beet was evaluated in a 3-year plot study in a semi-arid climate. Four irrigation treatments were evaluated; full irrigation and three deficit irrigation treatments where an irrigation application of 25 mm was applied when an average daily crop water stress index (CWSI) threshold of 0.2, 0.35, and 0.55 was exceeded. There were significant irrigation treatment differences in seasonal evapotranspiration, soil water extraction, seasonal average CWSI, root yield, estimated recoverable sugar (ERS) yield, and water use efficiencies. Seasonal soil water extraction of the full irrigation treatment was significantly less than for the DI treatments in all study years. In 2021 and 2022, soil water balanced based evapotranspiration was significantly less for the DI treatments compared to the full irrigation treatment. However, there was no significant difference in root yield, ERS yield, and water use efficiencies between the full irrigation treatment and irrigating when daily CWSI exceeded 0.2 in any study year. The results indicate that irrigating when average daily CWSI sugar beet exceeds 0.2 is an effective means for mild deficit irrigation scheduling to reduce seasonal irrigation requirements with no significant effect on root and ERS yield.

Calculation of sugar beet CWSI was an integral part of this study. A neural network model was used to estimate non-water stressed canopy temperature. Documentation of the neural network model and its use to estimate non-water stressed canopy temperature are demonstrated in a Microsoft Excel spreadsheet. Calculation of non-transpiring canopy temperature is also demonstrated in the spreadsheet. The spreadsheet computes CWSI based on five inputs: solar radiation, air temperature, relative humidity, wind speed, and measured canopy temperature.
Supplemental material for "Bioaerosols in Eastern Canadian Dairy Barns Using Tie- and Free-Stall Housing"
Authors: Bergeron Keven , Rossi Florent , Létourneau Valérie , Larios Dalila , Godbout Stéphane , Fournel Sébastien , Duchaine Caroline
Published: February 2024

  

This study characterizes air quality in dairy barns using tie-stalls or free-stalls. Air quality indicators characterized in this study include some microorganisms (molds, bacteria, and archaea), organic dust, and endotoxins. These indicators were quantified in five barns of each type. Microorganism quantification was made using qPCR and respective probes and primers. This document contains a table listing sequences for the used probes and primers as well as the targeted genes. It also contains additional analysis data for comparison between tie-stall barns and free-stall barns air quality. Variation coefficients were calculated to see if concentrations were more variable between the two types of barns. No significant difference was detected. Even though data are expressed in concentrations, emissions per hour were calculated using animal density. Emissions were compared between both types of barns, but no significant difference was detected.
Numerical investigation of effective nonlinear coefficient model for coupled third harmonic generation
Authors: Zheng Zihua , Tang Ziwen , Wei Zhiyi , Sun Jinghua
Published: February 2024

In this paper, the optimal solution of effective nonlinear coefficient of quasi-phase-matching (QPM) crystals for coupled third harmonic generation (CTHG) was numerically investigated. The effective nonlinear coefficient of CTHG was converted to an Ising model for optimizing domain distributions of aperiodically poled lithium niobate (APPLN) crystals with lengths as 0.5 mm and 1 mm, and fundamental wavelengths ranging from 1000 nm to 6000 nm. A method for reconstructing crystal domain poling weight curve of coupled nonlinear processes was also proposed, which demonstrated the optimal conversion ratio between two coupled nonlinear processes at each place along the crystal. In addition, by applying the semidefinite programming, the upper bound on the effective nonlinear coefficients deff for different fundamental wavelengths were calculated. The research can be extended to any coupled dual χ(2) process and will help us to understand better the dynamics of coupled nonlinear interactions based on QPM crystals.
Strip loaded waveguide amplifiers based on erbium-doped nanocomposites with 17 dB internal net gain
Authors: Tao Siliang , Song Hangyu , Zhao Dan , Yang Yu , Wang Shuangshuang , Yan Jinming , Wei Jiashuo , Wang Xibin , Qin Guanshi , Wang Fei , Zhang Daming
Published: February 2024

We propose a strip loaded amplifier employing SU-8 as the loaded waveguide and nanoparticles (NPs)-polymethyl methacrylate (PMMA) as the cladding layer. By leveraging the undoped SU-8 loaded waveguide, the polymer waveguide amplifier accomplished remarkably low transmission losses, reaching as low as 1.8 dB/cm at 1530 nm. We prepared NPs-PMMA nanocomposite by utilizing NaLu0.1Y0.7F4: Er3+, Yb3+ @NaLuF4 core-shell nanoparticles, which exhibited a significantly enhanced lifetime of 6.15 ms. An internal net gain of up to 17.7 dB was achieved on a strip loaded waveguide with a length as short as 0.5 cm when the on-chip pump power was 77 mW. Signal enhancement (SE) was measured at different wavelengths, revealing that the strip loaded waveguide exhibited broadband SE ranging from 1510 nm to 1570 nm, covering the C-band. To the best of our knowledge, this work has achieved the highest gain results reported thus far on a polymer matrix and provides an efficient method for optical amplification in passive devices on silicon and Si3N4 platforms, leveraging the ease of integration of polymer materials with diverse photonic platforms.
Sub-60-fs mode-locked Tm,Ho:CaYLuAlO4 laser at 2.05 µm
Authors: Liu Shande , Wang Peifu , Li Kuan , Lv Jiawen , Jin Yicheng , Xu Xiaodong , Wang Zhanxin , Liu Jian , Liu Junting , Zhao Yongguang
Published: February 2024

Tm,Ho:CaYLuAlO4 (Tm,Ho:CALYLO) crystal has wide emission spectra both for π-polarization and σ-polarization, showing significant potential for the generation of ultrashort pulses. Here, a widely tunable and passively mode-locked laser operation based on Tm,Ho:CALYLO crystal under two polarizations was demonstrated for what we believe to be the first time ever. For π-polarization, a maximum output power of 1.52 W and a tuning range of 255.3 nm were achieved in the continuous wave (CW) regime. In the mode-locked regime, a pulse duration of 68 fs and an average output power of 228 mW were achieved upon GaSb-based semiconductor saturable absorber mirror (SESAM). As for σ-polarization, a broader tuning range of 267.1 nm was realized, leading to the shorter pulse duration of 58 fs at 79.7 MHz repetition rate.
Structural, chemical, and optical design optimization of an Fe2+-doped chalcogenide fiber for mid-infrared lasing
Authors: Dawda Shubham , Dogariu Aristide , Schepler Kenneth L.
Published: February 2024

Optimization of an Fe2+-doped chalcogenide fiber is considered for mid-IR lasing. The concept of using a chalcogenide glass as a fiber matrix to support optically active Fe2+ ions in ZnSe crystal particles requires use of a protective shell to prevent dissolution of the ZnSe particles. Here, we investigate the effect that the shell has on optical scattering and subsequently the relative gain and loss for a range of particle size, shell thickness and loading fraction of the ZnSe particles. Scattering loss depends on the particle size and is found to be acceptably low for fiber lasing for sizes larger than a threshold size. Furthermore, upon considering collective scattering from the particle group, increasing the concentration is shown to reduce the scattering loss and to be helpful in improving the gain coefficient to scattering loss coefficient ratio. Proper optimization is expected to result in a viable Fe2+ mid-IR fiber laser.
A systematic review of oral wound healing indices
Authors: Rodriguez Amanda Beatriz , Alhachache Sara , Velasquez Diego , Chan Hsun-Liang
Published: February 2024

Wound healing monitoring for abnormality identification and intervention is crucial to securing a successful surgical outcome. Indices have been used to summarize the degree of healing. Given the increasing frequency of regenerative procedures which preserve dentition and implant stability, and the higher esthetic demands, an appraisal of the available indices is needed to identify the current knowledge gap. This study aimed to systematically review published oral wound healing indices and scores. Materials and Methods: A complete literature electronic search in 5 databases was conducted by two reviewers. A combination of keywords related to oral wound healing was used. Results: A total of 11 articles were included in the evaluation of various procedures (conventional periodontal procedures, guided tissue regeneration, soft tissue reconstruction procedures, and tooth extractions), at different time points (1 day to 12 weeks), with a focus on diverse clinical signs and symptoms. Frequently evaluated parameters included wound dehiscence/epithelialization (91%), tissue color (redness) (73%), suppuration (55%), swelling/edema (55%), and hemostasis (55%). Other less commonly used parameters include esthetics-related and patient-centered outcomes. Conclusion: The available indices evaluate a diverse group of subjective clinical signs and symptoms to estimate the underlying biological healing events and assess the degree of clinical success. The majority of the included indices are not validated. Quantitative and objective subclinical parameters including blood perfusion, biomaterial stability, and completeness of epithelialization, are needed for customized wound healing care and better outcome prediction.
Pneumocystis jirovecii pneumonia mortality risk associated with preceding long-term steroid use for the underlying disease: A multicenter, retrospective cohort study
Authors: Miyake Kohei , Senoo Satoru , Shiiba Ritsuya , Itano Junko , Kimura Goro , Kawahara Tatsuyuki , Tamura Tomoki , Kudo Kenichiro , Kawamura Tetsuji , Nakahara Yasuharu , Higo Hisao , Himeji Daisuke , Takigawa Nagio , Miyahara Nobuaki ,   Okayama Respiratory Disease Study Group (ORDSG)
Published: February 2024

Objective

Long-term steroid use increases the risk of developing Pneumocystis pneumonia (PcP), but there are limited reports on the relation of long-term steroid and PcP mortality.

Methods

Retrospective multicenter study to identify risk factors for PcP mortality, including average steroid dose before the first visit for PcP in non-human immunodeficiency virus (HIV)-PcP patients. We generated receiver operating characteristic (ROC) curves for 90-day all-cause mortality and the mean daily steroid dose per unit body weight in the preceding 10 to 90 days in 10-day increments. Patients were dichotomized by 90-day mortality and propensity score-based stabilized inverse probability of treatment weighting (IPTW) adjusted covariates of age, sex, and underlying disease. Multivariate analysis with logistic regression assessed whether long-term corticosteroid use affected outcome.

Results

Of 133 patients with non-HIV-PcP, 37 died within 90 days of initial diagnosis. The area under the ROC curve for 1–40 days was highest, and the optimal cutoff point of median adjunctive corticosteroid dosage was 0.34 mg/kg/day. Past steroid dose, underlying interstitial lung disease and emphysema, lower serum albumin and lower lymphocyte count, higher lactate dehydrogenase, use of therapeutic pentamidine and therapeutic high-dose steroids were all significantly associated with mortality. Underlying autoimmune disease, past immunosuppressant use, and a longer time from onset to start of treatment, were associated lower mortality. Logistic regression analysis after adjusting for age, sex, and underlying disease with IPTW revealed that steroid dose 1–40 days before the first visit for PcP (per 0.1 mg/kg/day increment, odds ratio 1.36 [95% confidence interval = 1.16–1.66], P<0.001), low lymphocyte counts, and high lactate dehydrogenase revel were independent mortality risk factor, while respiratory failure, early steroid, and sulfamethoxazole/trimethoprim for PcP treatment did not.

Conclusion

A steroid dose before PcP onset was strongly associated with 90-day mortality in non-HIV-PcP patients, emphasizing the importance of appropriate prophylaxis especially in this population.
Characterization of an undocumented CO2 hydrothermal vent system in the Mediterranean Sea: Implications for ocean acidification forecasting
Authors: D’Alessandro Michela , Gambi Maria Cristina , Bazzarro Matteo , Caruso Cinzia , Di Bella Marcella , Esposito Valentina , Gattuso Alessandro , Giacobbe Salvatore , Kralj Martina , Italiano Francesco , Lazzaro Gianluca , Sabatino Giuseppe , Urbini Lidia , Vittor Cinzia De
Published: February 2024

A previously undocumented shallow water hydrothermal field from Sicily (Southern Tyrrhenian Sea, Italy) is here described, based on a multidisciplinary investigation. The field, covering an area of nearly 8000 m2 and a depth from the surface to -5 m, was explored in June 2021 to characterise the main physico-chemical features of the water column, describe the bottom topography and features, and identify the main megabenthic and nektonic species. Twenty sites were investigated to characterise the carbonate system. Values of pH ranged between 7.84 and 8.04, ΩCa between 3.68 and 5.24 and ΩAr from 2.41 to 3.44. Geochemical analyses of hydrothermal gases revealed a dominance of CO2 (98.1%) together with small amounts of oxygen and reactive gases. Helium isotope ratios (R/Ra = 2.51) and δ13CCO2 suggest an inorganic origin of hydrothermal degassing of CO2 and the ascent of heat and deep-seated magmatic fluids to the surface. Visual census of fishes and megabenthos (mainly sessile organisms) allowed the identification of 64 species, four of which are protected by the SPA/BIO Protocol and two by the International Union for Conservation of Nature. The macroalgae Halopteris scoparia and Jania rubens and the sponge Sarcotragus sp. were the dominant taxa in the area, while among fishes Coris julis and Chromis chromis were the most abundant species. This preliminary investigation of San Giorgio vent field suggests that the site could be of interest and suitable for future experimental studies of ocean acidification.
TXNIP-mediated crosstalk between oxidative stress and glucose metabolism
Authors: Kim Stephanie , Ge Jianning , Kim Dokyun , Lee Jae Jin , Choi Youn Jung , Chen Weiqiang , Bowman James W. , Foo Suan-Sin , Chang Lin-Chun , Liang Qiming , Hara Daiki , Choi Inpyo , Kim Myung Hee , Eoh Hyungjin , Jung Jae U.
Published: February 2024

Thioredoxin-interacting protein (TXNIP) has emerged as a key player in cancer and diabetes since it targets thioredoxin (TRX)-mediated redox regulation and glucose transporter (GLUT)-mediated metabolism. TXNIP consists of two arrestin (ARR, N-ARR and C-ARR) domains at its amino-terminus and two PPxY (PY) motifs and a di-leucine (LL) motif for endocytosis at its carboxyl-terminus. Here, we report that TXNIP shuffles between TRX and GLUTs to regulate homeostasis of intracellular oxidative stress and glucose metabolism. While TXNIP functions as a gatekeeper of TRX by default, it robustly interacted with class I GLUTs through its C-ARR domain upon increase of intracellular reactive oxygen species. This interaction prompted the surface expression downregulation and lysosomal degradation of GLUTs by its carboxyl-terminal LL endocytic signaling motif to attenuate glucose uptake. Consequently, TXNIP expression significantly limited glucose uptake, leading to the suppression of glycolysis, hexosamine biosynthesis, and the pentose phosphate pathway. Our findings establish a fundamental link between ROS and glucose metabolism through TXNIP and provide a promising target for the drug development against GLUT-related metabolic disorders.
Validity and reliability of portable A-mode ultrasound in measuring body fat percentage: A systematic review with meta-analysis
Authors: Ferreira Luiz Fernando , Silva Elirez Bezerra da , Bomfim Alexander Barreiros Cardoso
Published: February 2024

The present Systematic Review with Meta-analysis study aimed to evaluate the validity and reliability of the Portable A-mode Ultrasound (P-US) for measuring body fat percentage (BF%). Only studies with participants of both genders which had assessed BF% using P-US compared to the reference standard were selected. Publications up until May 31, 2022 were searched in the MEDLINE, COCHRANE, Science Direct, Web of Science, LILACS, SciELO, PEDro, SPORT Discus, CINAHL and SCOPUS databases. QUADAS-2 was used to assess the risk of bias in the validity studies and QAREL was used for the methodological quality of reliability studies. The JAMOVI software program synthesized the results, from which the Pearson Correlation Coefficient (r) or the square root of the Multiple Linear Regression Determination Coefficient (R2) were extracted for the validity studies, and the Mean of Errors of the Bland-Altman Test (ME) and the Confidence Interval (95%CI) with Upper and Lower Limits for the reliability studies. A total of 13 studies were included, generating 26 results for the quantitative synthesis, 14 for validity and 12 for reliability. Regarding the validity results, a strong correlation was identified between the equipment (r = 0.870 [0.845–0.895], P<0.001), with moderate and true heterogeneity (I2= 53.47%, P = 0.003), presenting publication bias. A small effect size was identified regarding the reliability results, overestimating the results due to chance between the devices (ME = 0.207 [-0.798–1.212], P = 0.686), with low heterogeneity also due to chance (I2= 19.44%, P = 0.253), with no publication bias. All of the evaluated studies showed some violation of the instruments, confirming the high risk of bias and the low methodological quality. There is concern with heterogeneity for the validity results explained by the subgroups’ analysis. The P-US associated with anthropometric perimeters satisfactorily measures the BF% with samples greater than 100 participants, and males. The results in the reliability assessment show high agreement and high variability, greatly expanding the confidence interval, which should be viewed with reservations. This review received financial support from the Brazilian Air Force. The study was registered with PROSPERO under the number CRD42020166617.
Flexing with lines or pipes: Techno-economic comparison of renewable electricity import options for European research facilities
Authors: Hampp Johannes
Published: February 2024

Where local resources for renewable electricity are scarce or insufficient, long-distance electricity imports will be required in the future. Even across long distances, the variable availability of renewable energy sources needs to be managed for which dedicated storage options are usually considered. Other alternatives could be demand-side flexibility and concentrated solar power with integrated thermal energy storage. Here their influence on the cost of imported electricity is explored. Using a techno-economic linear capacity optimization, exports of renewable electricity from Morocco and Tunisia to CERN in Geneva, Switzerland in the context of large research facilities are modeled. Two different energy supply chains are considered, direct imports of electricity by HVDC transmission lines, and indirect imports using H2 pipelines subsequent electricity generation. The results show that direct electricity exports ranging from 58 EUR/MWh to 106 EUR/MWh are the more economical option compared to indirect H2-based exports ranging from 157 EUR/MWh to 201 EUR/MWh. Both demand-side flexibility and CSP with TES offer significant opportunities to reduce the costs of imports, with demand-side flexibility able to reduce costs for imported electricity by up to 45%. Research institutions in Central Europe could initiate and strengthen electricity export-import partnerships with North Africa to take on a leading role in Europe’s energy transition and to secure for themselves a long-term, sustainable electricity supply at plannable costs.
Integrated child development service (ICDS) coverage among severe acute malnourished (SAM) children in India: A multilevel analysis based on national family health survey-5
Authors: Chakraborty Ritankar , Joe William , ShankarMishra Udaya , Rajpal Sunil
Published: February 2024

Severe acute malnutrition (SAM) can be fatal for children, and potentially limit their cognitive and physical growth. The last three National Family Health Survey (NFHS) in India shows an increase in the prevalence of SAM among under-five children. Given the specific mandates under ICDS (Integrated Child Development Service) for SAM children, it is important to validate the coverage efficiency of ICDS on SAM children. This paper examines a possible association between the coverage efficiency of ICDS on SAM children. The study further aims to identify the determinants of ICDS service utilization among SAM children. We used data from the fifth round of the National Family Health Survey. Descriptive statistics was used to estimate the SAM coverage under ICDS. Multilevel Logistic Regression was used to identify the determinants of ICDS service utilization among SAM children. The burden of SAM is higher among older children (3+ age). Coverage of ICDS was more among younger children and the poorest households in the rural areas. Results from multilevel logistic regression showed that age had a significant relationship with the outcome variable. SAM children living in the rural areas had a significantly higher odds of being covered under ICDS service (OR 1.57; CI: (1.35, 1.82)) than their urban counterparts. Pregnant and lactating mothers who received ICDS services were significant determinants of SAM coverage under ICDS. There is no evidence that ICDS is more efficient in identifying and covering SAM children than non-SAM children. Despite special provisioning in place for SAM children, coverage of different ICDS services was similar to that of non-SAM children, and were in fact lower than non-SAM children for some categories. The study suggests that improving coverage of ICDS services among pregnant and lactating mothers would increase the coverage of ICDS services among SAM children.
Multiscale investigation of pore structure heterogeneity in carbonate rocks using digital imaging and SCAL measurements: A case study from Upper Jurassic limestones, Abu Dhabi, UAE
Authors: Sulieman Hind , Jouini Mohamed Soufiane , Alsuwaidi Mohammad , Al-Shalabi Emad W. , Al Jallad Osama A.
Published: February 2024

This study presents a comprehensive analysis of rock properties for a selected group of six carbonate reservoir rock samples revealing complex structures at various length scales. Experimental laboratory methods as well as image analysis techniques were conducted in this study to characterize the macro- and micro-pores in mud- and grain-dominated limestones samples from the Upper Jurassic Arab Formation (Arab D member). Mercury Injection Capillary Pressure (MICP), porosimeter, and permeameter lab measurements were employed to assess the pore network heterogeneity and complexity. In addition, a multiscale rock imaging approach was implemented to detect grain and pore phases at several length scales using Thin Sections (TS), Scanning Electron Microscopy (SEM), Focused Ion Beam Scanning Electron Microscopy (FIB-SEM), as well as 3D X-ray Computed Tomography (CT), and micro-computed tomography images (MCT). Furthermore, the multifractal analysis method was applied on the MICP and FIB-SEM to characterize quantitatively the heterogeneity of the pores in the studied samples. Heterogeneous samples 3R, 4M, 5W, and 6M display the highest non-uniformity degree Δα values, falling within the range of [1.21, 1.39] based on FIB-SEM images. Samples 1G, 2R, 3R, and 5W exhibit more heterogeneous pore structure, with Δα values ranging from 0.73 to 1.49 based on the MICP experiments. The results and findings confirm the effectiveness of multifractal parameters Δα and the asymmetry degree in the vertical axis Δf(α) in quantifying and characterizing rock heterogeneity.
Estimating the costs of adolescent HIV care visits and an intervention to facilitate transition to adult care in Kenya
Authors: Saldarriaga Enrique M. , Beima-Sofie Kristin , Wamalwa Dalton , Mugo Cyrus , Njuguna Irene , Onyango Alvin , John-Stewart Grace , Sharma Monisha
Published: February 2024

Introduction

Adolescents with HIV in sub-Saharan Africa face challenges transitioning to adult HIV care, which can affect long-term HIV care adherence and retention. An adolescent transition package (ATP) focused on transition tools can improve post-transition clinical outcomes, but its implementation costs are unknown.

Methods

We estimated the average cost per patient of an HIV care visit and ATP provision to adolescents. Data was collected from 13 HIV clinics involved in a randomized clinical trial evaluating ATP in western Kenya. We conducted a micro-costing and activity-driven time estimation to assess costs from the provider perspective. We developed a flow-map, conducted staff interviews, and completed time and motion observation. ATP costs were estimated as the difference in average cost for an HIV care transition visit in the intervention compared to control facilities. We assessed uncertainty in costing estimatesviaMonte Carlo simulations.

Results

The average cost of an adolescent HIV care visit was 29.8USD (95%CI 27.5, 33.4) in the standard of care arm and 32.9USD (95%CI 30.5, 36.8) in the ATP intervention arm, yielding an incremental cost of 3.1USD (95%CI 3.0, 3.4) for the ATP intervention. The majority of the intervention cost (2.8USD) was due ATP booklet discussion with the adolescent.

Conclusion

The ATP can be feasibly implemented in HIV care clinics at a modest increase in overall clinic visit cost. Our cost estimates can be used to inform economic evaluations or budgetary planning of adolescent HIV care interventions in Kenya.
Assessing community-level impacts of and responses to stay at home orders: The King County COVID-19 community study
Authors: Moloney Kathleen , Lamprea Montealegre Julio A. , Busch Isaksen Tania M. , Kennedy Mallory , Archer Megan , Contreras Carlos , Iyaz Daaniya , Randazza Juliette , Silva Javier , Errett Nicole A.
Published: February 2024

Background

At the beginning of the COVID-19 pandemic, non-pharmaceutical interventions (NPIs) of unprecedented scope and duration were implemented to limit community spread of COVID-19. There remains limited evidence about how these measures impacted the lived experience of affected communities. This study captured the early impacts and coping strategies implemented in King County, Washington, one of the first U.S. communities impacted by COVID-19.

Methods

We conducted a cross-sectional web-based survey of 793 English- and Spanish-speaking adult King County residents from March 18, 2020 –May 30, 2020, using voluntary response sampling. The survey included close- and open-ended questions on participant demographics, wellbeing, protective actions, and COVID-19-related concerns, including a freeform narrative response to describe the pandemic’s individual-, family- and community-level impacts and associated coping strategies. Descriptive statistics were used to analyze close-ended questions, and qualitative content analysis methods were used to analyze free-form narrative responses.

Results

The median age of participants was 45 years old, and 74% were female, 82% were White, and 6% were Hispanic/Latinx; 474 (60%) provided a qualitative narrative. Quantitative findings demonstrated that higher percentages of participants engaged in most types of COVID-19 protective behaviors after the stay-at-home order was implemented and schools and community spaces were closed, relative to before, and that participants tended to report greater concern about the pandemic’s physical health or healthcare access impacts than the financial or social impacts. Qualitative data analysis described employment or financial impacts (56%) and vitality coping strategies (65%), intended to support health or positive functioning.

Conclusions

This study documented early impacts of the COVID-19 pandemic and the NPIs implemented in response, as well as strategies employed to cope with those impacts, which can inform early-stage policy formation and intervention strategies to mitigate the negative impacts. Future research should explore the endurance and evolution of the early impacts and coping strategies throughout the multiyear pandemic.
A peripheral subepithelial network for chemotactile processing in the predatory sea slug Pleurobranchaea californica
Authors: Norekian Tigran , Liu Yichen , Gribkova Ekaterina D. , Cui Jilai , Gillette Rhanor
Published: February 2024

Many soft-bodied animals have extensive peripheral nervous systems (PNS) with significant sensory roles. One such, the sea slug Pleurobranchaea californica, uses PNS computations in its chemotactile oral veil (OV) in prey tracking, averaging olfactory stimuli across the OV to target likely source direction, or “stimulus place”. This suggests a peripheral subepithelial network (SeN) interconnecting sensory sites to compute the directional average. We pursued anatomy and connectivity of previously described ciliated putative sensory cells on OV papillae. Scanning electron microscopy (SEM) confirmed paddle-shaped cilia in clusters. Anti-tubulin and phalloidin staining showed connections to branching nervelets and muscle fibers for contraction and expansion of papillae. Ciliary cell processes could not be traced into nerves, consistent with sensory transmission to CNS via secondary afferents. Anti-tyrosine hydroxylase-stained ciliated cells in clusters and revealed an at least partially dopaminergic subepithelial network interconnecting clusters near and distant, connections consistent with PNS averaging of multiple stimulated loci. Other, unidentified, SeN neurotransmitters are likely. Confirming chemotactile functions, perfusible suction electrodes recorded ciliary spiking excited by both mechanical and appetitive chemical stimuli. Stimuli induced sensory nerve spiking like that encoding stimulus place. Sensory nerve spikes and cilia cluster spikes were not identifiable as generated by the same neurons. Ciliary clusters likely drive the sensory nerve spikes via SeN, mediating appetitive and stimulus place codes to CNS. These observations may facilitate future analyses of the PNS in odor discrimination and memory, and also suggest such SeNs as potential evolutionary precursors of CNS place-coding circuitry in the segmented, skeletonized protostomes and deuterostomes.
Research status of east Asian traditional medicine treatment for chronic cough: A scoping review
Authors: Lee Boram , Kwon Chan-Young , Kim Ye Ji , Kim Jae Hyun , Kim Kwan-Il , Lee Beom-Joon , Lee Jun-Hwan
Published: February 2024

Background

When patients continue to experience cough despite conventional treatment, East Asian traditional medicine (EATM) including herbal medicine and/or acupuncture has been frequently used. Previous systematic reviews of EATM treatment for chronic cough have been conducted mainly on herbal medicine, targeting patients with conditions that cause cough. In clinical practice, EATM interventions are not limited to herbal medicine, and considering that chronic cough is often caused by two or more conditions or unspecific causes, a comprehensive investigation is clinically relevant. We examined the current research status of EATM for chronic cough.

Methods

Based on Arksey and O’Malley’s scoping review methodological framework, a total of six English, Chinese, Korean, and Japanese electronic databases were searched on August 2022. Any clinical studies on EATM targeting chronic cough patients (regardless of their cause) were included.

Results

Among 474 included studies, the study designs were mainly randomized controlled trials (72.4%), and the population was evenly distributed between children and adults. The cause of cough was not reported in most studies (56.1%). The common cause of cough was upper airway cough syndrome and post-respiratory infection (9.5%, each), followed by mixed cause (7.6%), nonspecific cause (5.9%), and gastroesophageal reflux disease (4.0%). EATM was conducted for a mean of 19.1 days, and herbal medicine was the most common (80.6%). Conventional medication was frequently used as a control (81.2%). For outcomes, the total effective rate was the most frequently utilized (94.3%), followed by cough severity (53.8%). EATM treatment showed positive outcomes in most studies.

Conclusions

In future EATM studies, it is necessary to either specify the cause of chronic cough or to report that the study was targeting nonspecific chronic cough. In addition, high-quality studies assessing the efficacy of EATM with placebo control treatment should be conducted, using validated evaluation tools.
Effect of tempo on the age-related changes in temporal expectation driven by rhythms
Authors: Xu Zhihan , Si Wenying , Ren Yanna , Jiang Yuqing , Guo Ting
Published: February 2024

Temporal expectation refers to the capacity to allocate resources at a particular point in time, enabling us to enhance our behavior performance. Empirical evidence indicates that, among younger adults, temporal expectation can be driven by rhythm (i.e., regular sequences of stimuli). However, whether there are age-related changes in rhythm-based temporal expectation has not been clearly established. Furthermore, whether tempo can influence the relationship between rhythm-based temporal expectation and aging remains unexplored. To address these questions, both younger and older participants took part in a rhythm-based temporal expectation task, engaging three distinct tempos: 600 ms (fast), 1800 ms (moderate), or 3000 ms (slow). The results demonstrated that temporal expectation effects (i.e., participants exhibited significantly faster responses during the regular trials compared to the irregular trials) were observed in both the younger and older participants under the moderate tempo condition. However, in the fast and slow tempo conditions, the temporal expectation effects were solely observed in the younger participants. These findings revealed that rhythm-based temporal expectations can be preserved during aging but within a specific tempo range. When the tempo falls within the range of either being too fast or too slow, it can manifest age-related declines in temporal expectations driven by rhythms.
A systematic review on the direct approach to elicit the demand-side cost-effectiveness threshold: Implications for low- and middle-income countries
Authors: Nu Vu Anh , Hoang Minh Van , Lindholm Lars , Sahlen Klas Göran , Nguyen Cuc Thi Thu , Sun Sun
Published: February 2024

Several literature review studies have been conducted on cost-effectiveness threshold values. However, only a few are systematic literature reviews, and most did not investigate the different methods, especially in-depth reviews of directly eliciting WTP per QALY. Our study aimed to 1) describe the different direct approach methods to elicit WTP/QALY; 2) investigate factors that contribute the most to the level of WTP/QALY value; and 3) investigate the relation between the value of WTP/QALY and GDP per capita and give some recommendations on feasible methods for eliciting WTP/QALY in low- and middle-income countries (LMICs). A systematic review concerning select studies estimating WTP/QALY from a direct approach was carried out in seven databases, with a cut off date of 03/2022. The conversion of monetary values into 2021 international dollars (i$) was performed via CPI and PPP indexes. The influential factors were evaluated with Bayesian model averaging. Criteria for recommendation for feasible methods in LMICs are made based on empirical evidence from the systematic review and given the resource limitation in LMICs. A total of 12,196 records were identified; 64 articles were included for full-text review. The WTP/QALY method and values varied widely across countries with a median WTP/QALY value of i$16,647.6 and WTP/QALY per GDP per capita of 0.53. A total of 11 factors were most influential, in which the discrete-choice experiment method had a posterior probability of 100%. Methods for deriving WTP/QALY vary largely across studies. Eleven influential factors contribute most to the level of values of WTP/QALY, in which the discrete-choice experiment method was the greatest affected. We also found that in most countries, values for WTP/QALY were below 1 x GDP per capita. Some important principles are addressed related to what LMICs may be concerned with when conducting studies to estimate WTP/QALY.
What should I use to calculate vehicle EES?
Authors: Moravcová Pavlína , Bucsuházy Kateřina , Zůvala Robert , Semela Marek , Bradáč Albert
Published: February 2024

Comprehensive crash analysis includes calculating impact speed, which requires the determination of kinetic energy expended on the deformation of the vehicle’s structural elements at the point of contact during a collision. The accuracy of the input data affects the resulting analysis of the crash. Therefore, this article aims to analyse selected factors influencing the determination of Energy Equivalent Speed (EES) determination using the CRASH3 algorithm: the extent of damage using defined measurement points, deformation width, and also limit speed b0. The variables were varied depending on selected factors such as the extent of damage, the type of collision (overlap), and also vehicle type (vehicle category classification). The presented study concluded that using 2 equally spaced measurement points to define the deformation profile should not be recommended in forensic practice when using CRASH3 algorithm. Using 7 measurement points seems more appropriate in case of equal spacing, even though the differences in calculated EES are not high when using 5 or 6 measurement points, especially with respect to the inaccuracy/technically acceptable tolerance of the EES value determination. The resulting EES is significantly influenced by variation of the deformation width. The used b0 range had a significant effect on the resulting EES value only in the case of SUVs. These vehicles show higher stiffness, which supposes the use of lower b0 values should not be recommended.
Machine perfusion of the liver and in vivo animal models: A systematic review of the preclinical research landscape
Authors: Liu Wenjia , Jiang Decan , Schulz Mareike , Figueiredo Constança , Dondossola Daniele , Meister Franziska Alexandra , Tihanyi Dora Krisztina , Mehrabi Arianeb , Tolba Rene Hany , Czigany Zoltan , Ernst Lisa
Published: February 2024

Machine perfusion (MP) is often referred to as one of the most promising advancements in liver transplantation research of the last few decades, with various techniques and modalities being evaluated in preclinical studies using animal models. However, low scientific rigor and subpar reporting standards lead to limited reproducibility and translational potential, hindering progress. This pre-registered systematic review (PROSPERO: CRD42021234667) aimed to provide a thematic overview of the preclinical research landscape on MP in liver transplantation using in vivo transplantation models and to explore methodological and reporting standards, using the ARRIVE (Animal Research: Reporting of In Vivo Experiments) score. In total 56 articles were included. Studies were evenly distributed across Asia, Europe, and the Americas. Porcine models were used in 57.1% of the studies, followed by rats (39.3%) and dogs (3.6%). In terms of graft type, 55.4% of the studies used donation after cardiac death grafts, while donation after brain death grafts accounted for 37.5%. Regarding MP modalities, the distribution was as follows: 41.5% of articles utilized hypothermic MP, 21.5% normothermic MP, 13.8% subnormothermic MP, and 16.9% utilized hypothermic oxygenated MP. The stringent documentation of ARRIVE elements concerning precise experimental execution, group size and selection, the choice of statistical methods, as well as adherence to the principles of the 3Rs, was notably lacking in the majority of publications, with less than 30% providing comprehensive details. Postoperative analgesia and antibiotics treatment were not documented in 82.1% of all included studies. None of the analyzed studies fully adhered to the ARRIVE Guidelines. In conclusion, the present study emphasizes the importance of adhering to reporting standards to promote reproducibility and adequate animal welfare in preclinical studies in machine perfusion. At the same time, it highlights a clear deficiency in this field, underscoring the need for further investigations into animal welfare-related topics.
Low profile high gain RHCP antenna for L-Band and S-Band using rectangular ring metasurface with backlobe suppression
Authors: Khan Sundas Farooq , Khan Bilal Muhammad , Mairaj Rasool Khan Tariq
Published: February 2024

In this reported work a single feed, miniaturized, dual layer, and low profile antenna is presented for 1.575GHz frequency band. The proposed antenna offers high gain, lower noise bandwidth, with better sensitivity and range. The ground choke technique is used for back lobe suppression. The prototype is fabricated on FR 4 substrate using manual fabrication technique. This offers an inexpensive and readily available fabrication. Therefore, fabricated antenna is small size, low cost, easily fabricated and tested for satellite communication. The antenna comprises of two layers, containing a patch radiator and a Metasurface layer with 3x3 rectangular ring resonators. The layers are separated using foam with a 12mm width. The proposed prototype is radiating at 1.575GHz and 2.33GHz with an overall dimension of 85.6 x 68.4 x 15.204 mm. The developed antenna provides a gain of 5.9 dBi. The simulated results are verified using VNA and anechoic chamber testing. Moreover, the developed antenna has been successfully tested for L-Band Satellite communication in real time scenario without any LNA. Higher Gain due to Metasurface increase the efficiency of the system. The promising results indicate the aptness of the developed antenna for real-world applications of L-Band and S-Band.
Comparative study of stretched-exponential and kurtosis models of diffusion-weighted imaging in renal assessment to distinguish patients with primary aldosteronism from healthy controls
Authors: Wen Deying , Peng Pengfei , Yue Xun , Xu Chenxiao , Pu Qian , Ming Yue , Yang Huiyi , Zhang Miaoqi , Ren Yan , Sun Jiayu
Published: February 2024

Purpose

To compare the ability of diffusion parameters obtained by stretched-exponential and kurtosis models of diffusion-weighted imaging (DWI) to distinguish between patients with primary aldosteronism (PA) and healthy controls (HCs) in renal assessment.

Materials and methods

A total of 44 participants (22 patients and 22 HCs) underwent renal MRI with an 11 b-value DWI sequence and a 3 b-value diffusion kurtosis imaging (DKI) sequence from June 2021 to April 2022. Binary logistic regression was used to construct regression models combining different diffusion parameters. Receiver-operating characteristic (ROC) curve analysis and comparisons were used to evaluate the ability of single diffusion parameters and combined diffusion models to distinguish between the two groups.

Results

A total of six diffusion parameters (including the cortical anomalous exponent term [α_Cortex], medullary fractional anisotropy [FA_Medulla], cortical FA [FA_Cortex], cortical axial diffusivity [Da_Cortex], medullary mean diffusivity [MD_Medulla] and medullary radial diffusivity [Dr_Medulla]) were included, and 10 regression models were studied. The area under the curve (AUC) of Dr_Medulla was 0.855, comparable to that of FA_Cortex and FA_Medulla and significantly higher than that of α_Cortex, Da_Cortex and MD_Medulla. The AUC of the Model_all parameters was 0.967, comparable to that of Model_FA (0.946) and Model_DKI (0.966) and significantly higher than that of the other models. The sensitivity and specificity of Model_all parameters were 87.2% and 95%, respectively.

Conclusion

The Model_all parameters, Model_FA and Model_DKI were valid for differentiating between PA patients and HCs with similar differentiation efficacy and were superior to single diffusion parameters and other models.
Study on the failure characteristics of sliding surface and stability analysis of inverted t-type retaining wall in active limit state
Authors: Zeng Yongqing , Hu Weidong , Chen Meixin , Zhang Yinghuan , Liu Xiaohong , Zhu Xinnian
Published: February 2024

This paper investigates the sliding surface failure characteristics, earth pressure distribution law and stability safety factor of inverted T-type retaining wall by using the finite element limit analysis software OptumG2, the effects of width of wall heel plate, width of wall toe plate, thickness of bottom plate, soil–wall interface friction angle, soil cohesion and soil internal friction angle of filling on the failure characteristics of sliding surface, the earth pressure distribution law and stability safety factor of retaining walls are analyzed, The stability safety factor of the retaining wall showed a gradually increasing trend as the width of wall heel plate and wall toe plate increased; as the bottom plate thickness increases, the stability safety factor of the retaining wall gradually increases; as the soil-wall interface element reduction coefficient rises, that is, the internal friction angle of the soil-wall gradually increases to the soil internal friction angle, the stability safety factor of the retaining wall gradually increases; as the soil cohesion and internal friction angle increase, the stability safety factor of the retaining wall progressively increases. The safety factor of retaining wall increases by 0.45 for every 0.5m increase in the width of the wall heel plate; the safety factor of the retaining wall increases by 0.29 when the width of the wall toe plate increases by 0.5m; for every 0.5m increase in the width of wall plate thickness, the safety factor of the retaining wall is increased by 0.62; for every 0.25 increase in soil-wall interface element reduction coefficient, the safety factor of the retaining wall increases by 0.29; for every increase of 5KPa in soil cohesion, the safety factor of the retaining wall increased by 1.16; for every 5° increases in soil internal friction angle, the safety factor of retaining wall increases by 0.6. The research is significant for studying the failure laws and stability of retaining walls and providing references for retaining wall design.