bluuebunny/crossref_metadata_2025 huggingface dataset:
Learning about teaching: the role of reflection in the work of English language teachers
Authors: Jelešković Emina
Published: October 2023

Teachers are pillars of education. Their lifelong learning is a prerequisite for improving their teaching practice. An important aspect of teachers’ learning is the reflection on their own experiences in the classroom, whereby they will acquire new knowledge and gain confidence which is especially important for novice teachers. The paper presents an overview of literature on the role of reflection for teachers in general and teachers of English as a foreign language specifically. The paper also includes the analysis of activities conducted by a group of 10 students, future teachers of English as a foreign language, who were taught the importance of reflection. The students were enrolled in English Phonetics course at English Language and Literature program – the teaching track at International University of Sarajevo. The qualitative method was applied, whereby activities conducted to raise students’ awareness of the importance of reflection for teaching were described and analysed. The approach may be described as action research aimed at examining students’ attitudes on reflection, as well as examples of good practice in teacher education. In order to familiarize future teachers of English as a foreign language with the importance of reflection for teaching, the following activities were conducted: microteaching, reflecting on one’s own microclass, peer review, and writing the reflection log. Firstly, students selected topics for 10-minute classes they held, which were related to English Phonetics. Students were free to choose the topic for their class and the age of students and their level of English proficiency, whereupon they tailored their classes to their students’ needs. The students video recorded their micro-classes with their own mobile phone cameras and were told to watch the video recording of their class prior to writing the reflection log. They commented on the classes they held, and other students in class also provided their feedback on each microclass. Finally, students filled-in a short survey in which they commented on the conducted activities and shared their impressions. The conclusion is that students have recognized the role and the importance of reflection for the teaching profession. Majority of them were happy to take on the teacher’s role and they demonstrated their autonomy, creativity and innovativeness.
Learning styles as determinants of self-efficacy in children of primary school age
Authors: Leto Aldina
Published: October 2023

The paper presents the results of research conducted on a sample of 126 students from the seventh to the ninth grade of the Elementary School in Mostar. The theoretical part of the paper discusses learning, learning styles and student self-efficacy. The aim of the work was to examine whether learning styles are a significant predictor for the development of self-efficacy in elementary school-age children, and we also examined gender differences in learning styles and self-efficacy. The results we obtained suggest that learning styles are significant determinants for explaining self-efficacy when it comes to auditory learning style. Thus, the results indicate that auditory style as a dimension of learning style is a significant determinant of self-efficacy (F3/109=3.00 p < 0.05, β =0.247, p< 0.05), while kinesthetic and visual style are not statistically significant predictors. Also, the results indicated that there is a statistically significant difference in self-efficacy with regard to gender. The self-efficacy of male and female students differs statistically significantly, p< 0.05, where girls (M = 26.82) had a statistically significantly higher score than boys (M= 21.06), (t=-2.845, p < 0, 05). The results show us that there are statistically significant differences between male and female students in the perception of the dimension of learning style when it comes to auditory style, where girls had a higher score (M=20.08) compared to boys (M= 18.57). (t=-2, 469, p < 0.05). Kinesthetic and visual style, as dimensions of learning style, did not show statistically significant gender differences.
Technological Forensic Auditing and Financial Crime Detection in Nigeria: A Study of Selected Deposit Money Banks
Authors: Eguando Temisan
Published: October 2023

Financial crime has been one of the current challenges faced by organizations especially deposit money banks. To ameliorate this ugly development, technology-enabled forensic auditing was introduced in addition to conventional auditing. This study examined the impact of technological forensic auditing on financial crime detection in Nigeria; a study of selected deposit money banks in Nigeria. The theories reviewed in the study are the strain theory, the theory of inspired confidence, and the credibility theory. The study adopted the survey design. The population of the study is made up of the accounting staff of five selected deposit money banks in Delta state namely; Zenith, First Bank, United Bank for Africa (UBA), Fidelity Bank, and Sterling Bank with a statistic of fifty-eight (58) staff/respondents. Data for the study were generated through the distribution of well-structured questionnaires to the corresponding respondents. Data was analyzed with the multiple linear regression method. The study found that robotic process automation, textual analysis, and data analytics contribute significantly to detecting financial crime in selected deposit money banks in Nigeria. It is therefore the recommendation of this study that forensic audit firms and deposit money banks should strategically employ the usage of software applications that can permit data analytics, textual analysis, and robotic process automation to redeem the credibility image of the forensic auditors’ report.
Material Lore as an Appendage of Folklore: The Kola Nut Example
Authors: U. Nnyagu , A. Igwedibia
Published: October 2023

Kolanut is an indispensable aspect of the Igbo tradition. As an integral part of the Igbo tradition, kolanut is present in every traditional and customary festival in all parts of the Igbo society. It is held in high esteem in Igbo as no festival would take place without the presence of kola. According to the tradition, kola nuts must be prayed with, broken and eaten by the people present before any occasion can progress. In the same vein, any visitor to an Igbo person, not offered a kola nut by the guest is simply understood to mean that he is not welcomed by the guest. Despite the role of kolanut in the Igbo society, many Igbo people are ignorant of the significance of kolanut and the right way to use kola nuts for an occasion. The researchers are aware that many people have written on kola nuts but the writers concentrated solely on the importance of kola nuts. In this paper, the researchers have decided to take a different part by vividly analysing the significance of kolanut in the Igbo society, with emphasis on the symbolic implications of each type of the Igbo kola nuts. As the research bothers on culture, the researchers see New Historicism as the most appropriate theoretical framework for the study.
Combating Financial Crimes through Forensic Audit: Evidence from Nigeria
Authors: T.A. Gideon , F.O. Opefolu , A.B. Yunus , A.D. Abdulrasaq
Published: October 2023

Curbing the menace of financial crimes through forensic audit is imperative due to the global failure of statutory audit. This study therefore examined curbing Financial Crimes through Forensic Audit: Evidence from Nigeria. This study employed a survey research method and obtained primary data sources collated through the questionnaire. The data collected was analyzed using regression models. The research discovered that P-value = 0.00<0.05 level of significance and the regression line is CFCs = 0.335 + 0.746β1 + 0.042β2-0.078β3+ut. The study also found that data based collection and data mining are effective enough and capable of curbing financial crimes in Nigeria, although ratio analysis is weak in doing that. The research concluded that forensic audit techniques are effective in combating financial crimes in Nigerian private sector. This study recommended that forensic audit courses should be given more spaces in the academic curricula of Universities to increase its awareness in Nigeria.
PENGARUH PEMBERIAN KATEKIN TERHADAP KULTUR SEL KANKER SERVIKS
Authors: Aulia Bakhtra Dwi Dinni , Kamal Uyun Hendri Satria , Eriadi Aried , Fajrina Anzharni , Wiliantari Selvia , Pranciska Witdia , Wandani Jesica Desta
Published: October 2023

Kanker serviks merupakan salah satu kanker paling mematikan bagi wanita. Salah satu terapi untuk mengobati kanker serviks adalah kemoterapi. Agen kemoterapi berasal dari bahan kimia sintetis dan memiliki efek samping yang merugikan. Tanaman gambir (Uncaria gambir Roxb) merupakan tanaman yang memiliki aktivitas sitotoksik. Penelitian ini bertujuan untuk mengetahui aktivitas sitotoksik dengan metode MTT, penghambatan migrasi sel dengan metode scratch assay, dan induksi kematian sel dengan metode double staining. Dari hasil penelitian, katekin yang diisolasi dari gambir mempengaruhi pertumbuhan sel biakan HeLa dengan nilai IC50 sebesar 3,1 µg/mL. Katekin yang diisolasi dari Gambir berpengaruh terhadap penghambatan migrasi sel HeLa; Hasilnya adalah penghambatan terbesar ditemukan pada konsentrasi yang paling signifikan, yaitu pada 80 µg/mL, dan rata-rata area migrasi sel adalah 2,26 mm/jam. Katekin dapat menginduksi apoptosis pada sel kultur HeLa. Dari hasil penelitian dapat disimpulkan bahwa katekin yang diisolasi dari Uncaria gambir mempengaruhi sel kultur HeLa.
The Contribution of Parents Involvement towards Students’ Academic Performance at Ugandan Certificate of Education in Public Secondary
Authors: Alfred Mugomba , Kiggundu Ssegawa E James , Musa Muwaga , Wamaungo Juma Abdu
Published: October 2023

The research aimed to evaluate parental influence on students' academic achievement in high school. It investigated academic performance, parental involvement, and their impact on secondary school students. Using a cross-sectional survey with 357 participants including head teachers, teachers, students, and BOG members, a self-administered questionnaire was utilized. Results indicated 80-89% score improvements in reading and writing skills, though fluency requires over 90%. Homework had 80-98% accuracy, but stronger focus was needed. Poor concentration and attendance highlighted the necessity for more support. Students struggled with question comprehension and irregular achievement. Parental engagement in health programs scored neutrally, signaling a need for increased involvement. Involvement in learning-related responsibilities was hindered by behavioral issues. Positive correlations existed between parental engagement and academic success, including safety, diversity, and regulatory aspects. Writing materials positively impacted, while reading materials showed a decline. Counseling services exhibited a weak correlation. Overall, parental involvement significantly predicted UCE students' academic improvement (B = 0.502; p = .000 < 0.05), contributing to 50.2% positive changes.
Transformation of Educational Management in Shaping the Character of Santri at the Purba Baru Musthafawiyah Traditional Islamic Boarding School
Authors: Sabli Muhammad , Ritonga Ahmad Husein , Shalahudin Shalahudin
Published: October 2023

The purpose of this study is to determine the impact of educational management on the character development of students at the Musthafawiyah Purba Baru Traditional Islamic Boarding School in Mandailing Natal Regency, North Sumatra Province. This is a descriptive qualitative study in which data was gathered through observation, interviews, and documentation. The research subjects included foundation administrators, pesantren leaders and vice-chairmen, teachers, and students. According to the findings of the study, the transformation process of educational management in forming the character of students at the Musthafawiyah Purba Baru Traditional Islamic Boarding School, Mandailing Natal Regency, North Sumatra Province, has been implemented in the form of a clean, honest, disciplined, trustworthy, independent, respectful, and simple character carried out through yellow book learning activities. Kyai, teachers, hostel supervisors, peers, and yourself all internalize these character values. Despite the fact that it is not optimally responsive to the times and has yet to determine the focus of character development.
To Compare the Effectiveness of Kegel’s Exercise and Paula Method in women with Urinary Incontinence
Authors: Rajalaxmi V. , Swetha P. , Balathandayutham K. , Tharani G. , Vaishnavi G. , Sridevi G. , Vendhan G.Venu
Published: October 2023

Objective of The Study: The study aims to compare the effectiveness of Paula method and Kegel's exercise in women with urinary incontinence. Background of The Study: Pelvic floor muscle weakness is one of the cause for urinary incontinence. Conservative management such as pelvic floor muscle training and Paula method is commonly recommended as first-line therapy for women with urinary incontinence. The purpose of the study is to examine the efficacy of circular muscle strengthening (Paula method) as opposed to pelvic floor muscle training (PMFT) on stress urinary incontinence. Methodology: This study was a comparative study design with pre and post type with 40 subjects randomly divided into two groups (group A and group B). Group A received Kegel’s exercise and Group B received Paula method. Result: On comparing Pre test and Post test within Group A and Group B of ICIQ score, QOL score, sexuality questionnaire score shows highly significant difference in mean values at P ≤ 0.001. Conclusion: This study concludes that Paula method decreases frequency of urinary incontinence by strengthening sphincter muscles. Compared to the Kegel’s exercise, Paula method showed greater difference in decreasing the frequency of urinary incontinence.
The Pharmacological Role of Ashwagandha in Cypermethrin-Induced Spleen Toxicity in mice
Authors: Namdev Narendra , Rai Gayatri , Mahobiya Payal
Published: October 2023

The current study is designed to investigate the immunoprotective efficacy of ashwagandha against cypermethrin-induced spleen toxicity in mice. Animals were divided randomly into four groups with six mice per group. Group, I served as control, group II cypermethrin treated, group III cypermethrin and ashwagandha co-treated, and group IV ashwagandha treated, all doses are given orally for 28 days. Samples were collected at the end of the experiment and later biochemical, histological, and hematological parameters were analyzed. A significant decrease was seen in the hematological parameters like hemoglobin percentage (Hb%), RBC, WBC, and MCH. The biochemical parameters like lipid peroxidation (*LPO) (p<0.05), H2O2 (**p<0.01), Nitric oxide (NO), and Catalase (**p<0.01), increased significantly and the Glutathione-S-transferase (GST) (**p<0.01), Glutathione reductase and Superoxide dismutase (**p<0.01) decreased significantly in cypermethrin exposed group as compared to control. The co-treatment with ashwagandha showed significant prevention in hematological and biochemical parameters. The histopathological investigation shows, the increased toxicity in the spleen of the cypermethrin exposed group as compared to the control and ashwagandha played a preventive role in the case of cypermethrin toxicity.
Cholinesterases as hemolytic and Inflammatory markers in Beta thalassemia trait patients
Authors: P Prathyusha , K Sudha , M Pawar Neelam , K Reshma , K Sowndarya
Published: October 2023

Beta thalassemia trait (BTT) is one of the most common monogenic disorders characterized by increased alpha and gamma chains with concomitant decrease in beta chains. These patients are clinically asymptomatic with mild anemia, subclinical inflammation and endothelial dysfunction. This study was undertaken to determine the role of cholinesterases in BTT. The study population included 30 BTT patients and 30 age and sex matched controls. Patients were labelled as BTT only if they had Hb A2 >3.5 and/ HbF>2 by variant analysis using cation HPLC. Percentage hemolysis, erythrocyte acetyl cholinesterase (AChE), plasma butyryl cholinesterase (BChE) and globulins were estimated by spectrophotometric methods. Intracellular adhesion molecule (ICAM-1) was evaluated by ELISA. Percentage hemolysis was significantly high in BTT patients. Both the cholinesterases were lower in BTT patients compared to controls. Decrease in BChE was statistically significant (p< 0.0001). An apparent increase in plasma ICAM-1 was observed in BTT patients compared to the normal group. The increase in plasma globulins was statistically significant in BTT (p<0.0001). AChE and HbA1C showed significant negative correlation with percentage hemolysis. Further, acetylcholinesterases showed a statistically significant negative correlation with ICAM-1. A negative correlation between globulins and cholinesterases in BTT, highlights the involvement of cholinesterases in inflammation.Based on our findings, we conclude that cholinesterases play a key role in inflammation and can be considered as biomarkers of hemolysis in BTT.
Design and Development of Matrix Diffusion Control Transdermal Drug Delivery System for Antiemetic Drug
Authors: Nagdev Sanjay , Agrawal Omprakash , Md. Usman Rageeb
Published: October 2023

Delivery of drugs into the systemic circulation via transdermal drug delivery system is well known. Transdermal drug delivery system is one of the most reliable and convenient delivery system for the delivery across skin. The aim of this research project is to develop a matrix diffusion control transdermal therapeutic system that combines the drug Ramosetron hydrochloride with an amount of hydrophilic and hydrophobic polymers using a solvent extraction method. Ramosetron hydrochloride is a highly potent drug and has an extended duration of action ad minor side effects despite the severity that it undergoes hepatic pass metabolism and therefore the purpose of this study was to prepare a transdermal patch for Ramosetron hydrochloride for the treatment of chemotherapy induced nausea and vomiting (Anti-emetic action) and evaluate it for various parameters.
PEG-4000 Ameliorates morphine-induced constipation in mice through inhibition of AQP-3 mRNA Expression
Authors: Rahmadi Mahardian , Iqbal Zuhaela , Nanda Pratama Ikbar , Anindita Karunia Rifky , Derry Puspitasari Arina , Nisak Khoirotin , Setiya Budiatin Aniek
Published: October 2023

Morphine is μ-opioid receptor (MOR) agonist that is used clinically for patients suffering from moderate to severe pain. Morphine can cause constipation due to activation of μ-opioid receptors in the central nervous system and the nervous system in the gastrointestinal tract. It is caused by increasing the expression of AQP-3 in the instestine through increased of serotonin by enterochromaffin cells. PEG 4000 is one of the osmotic laxatives used to treat Opioid Induced Constipation (OIC). PEG 4000 affects the upregulation of serotonin re-uptake which can lead to expression enhancement of AQP-3. The purpose of this study was to analyze the effect of PEG 4000 on expression changes of aquaporin-3 in mice colon induced acute constipation with morphine.Constipation conditions and the effectiveness of laxative therapy are indicated by constipation parameters in the form of fecal water content and stool weight. This study used 36 male mice of the Balb/c line genus which were divided into 3 groups, normal saline, morphine, and morphine + PEG 4000. Each group was further divided into 2 subgroups based on the time of observation, namely the first hour and fifth hour after morphine induced. The expression of AQP-3 was observed using Polymerase Chain Reaction (PCR) method. The result of this study showed that the administration of PEG 4000 to mice induced constipation with morfine could decrease the expression of AQP-3 from (146,413±1,736) to (118,411±3,476) with p value <0,05, increase the percentage of fecal water content from (0,000±0,000%) to (28,903±12,930%) with p value <0,05 and increase the stool weight from (0,000±0,000g) to (0,928±0,178g) with p value <0,01 From these results, it can be concluded that the administration of PEG 4000 in morphine induced constipation to mice was effective in reducing AQP-3 expression as well as increasing the percentage of fecal water content and stool weight.
Change of Compressive Strength Ti-6al-4v Sandblasted Al2O3 50μm Post Dynamic Pressure Treatment In vitro
Authors: Prabowo Harly , Samantha Patricia , Mundiratri Karina , Firman Putranto Ananda
Published: October 2023

Objective: The implant material that is often used is Ti-6Al-4V (grade 5 titanium). One of the requirements for successful implant placement is osseointegration which is a structural and functional relationship between the bone and the implant surface. To improve the osseointegration of the implant, modifications can be made to the implant surface, one of which is sandblasting which serves to make the implant surface rough enough to increase mechanical interlocking which allows better cell attachment. But on the other hand, this technique can reduce the endurance of the implant so it increases the possibility of fracture of the implant. Aim: The aim of the study is to determine the changes in the properties of Ti-6Al-4V after being sandblasted with 50μm AL2O3. 16 Ti-6Al-4V implants that had been blasted with 50μm AL2O3 and 16 Ti-6Al-4V implants without sandblast were given dynamic treatment with a pressure of 100 N for 2 million times, with a frequency of 15 Hz and then tested with a compressive test. Result: There was a significant average difference between the two groups as indicated by the results in the group without surface treatment (1682 N) and in the group that was sandblasted with 50 μm Al2O3 (815 N). Conclusion: Sandblasting using 50μm Al2O3 can reduce the endurance of Ti-6Al-4V implants because microcracks left by Al2O3 on the implant surface can lead to fracture initiation.
Study of maternal and neonatal outcome in women with one previous lower segment caesarean scar in Raja Isteri Pengiran Anak Saleha Hospital (RIPAS)
Authors: Ni Ni Soe , Caroline. C. P. Tan. , Myo Tun Hlaing , Mon Yee Mon
Published: October 2023

Background: The rate of primary caesarean section (CS) is on the rise; it was 30.8% for primiparous women and 11.5% for multiparous women. A trial of vaginal delivery can prevent the risk of repeat CS. Aim: The study was to determine the success rate, and also maternal and neonatal implications of VBAC (Vaginal Birth after Caesarean), attempted in women with one previous lower segment caesarean section (LSCS). Materials and Methods: The retrospective and descriptive study was carried out in a tertiary care hospital, RIPAS Hospital, Brunei Darussalam, over a period of three months (from February 2010 to May 2010). All women with prior LSCS who are suitable for a trial of labour after the previous caesarean (TOLAC) were included in our study. Sixty-one pregnant women with a history of one previous LSCS were enrolled in the study. Results: In our study (38/61) 62.3% of patients had a successful VBAC, and (23/61) 37.7% had undergone a repeat emergency LSCS. In those who had the previous VBAC, cervical dilatation of >4 cm at the time of admission and those who had the previous VBAC are significant factors for a successful VBAC. Conclusion: The trial of VBAC in selected cases has great importance in the present era of the rising rate of primary CS, as it has a considerable success rate and is not associated with serious maternal and foetal morbidity and mortality.
Quantitative Analysis of Caffeine in different commercial kinds of coffee in Iraq
Authors: Eldalawy Rasha , Hussein Kutaif Rana , Amir Tawfeeq Tahany , Fayyadh Mohammed Shamil
Published: October 2023

Caffeine is a widely consumed pharmacologically active substance around the world, Caffeine is a purine alkaloid derived from methylxanthine that is readily permeable through the blood-brain barrier and stimulates the adenosine receptors in the brain leading to its central nervous system stimulant activity. Most people regulate their caffeine consumption in accordance with the objective and subjective effects produced from the methylxanthine, However, individual response to caffeine varies greatly from person to person due to the variation in metabolism, age, sex, hormones, clearance, weight, genes, medicine intake and smoking behavior, therefore the amount of caffeine required to achieve the desired effect also varies greatlyand Since that the coffee beans are the world's primary sources of dietary caffeine this study was designed to determine the percent of the caffeine in different commercial coffee brands, the isolated caffeine was identified by different qualitative methods like TLC, and FTIR.
Assessment of Anti-urolithic effect of the Ocimum basilicum L. seed extract on Ethylene Glycolinduced urolithiasis in male rats
Authors: Patel Ravindrakumar K , Patel Sandip B , Vyas Niraj
Published: October 2023

This research aimed to assess the effect of Ocimum basilicum L. seed extract on the urolithiasis. Rats were treated with Cystone (750mg/kg) and hydro-alcoholic extracts in 250 and 500mg/kg doses for 28days. On Day 29, Ethylene glycol induced urolithiasis was verified by evaluating urinary parameters, biochemical parameters, oxidative stress parameters and histology of kidneys. Extract treatment attenuated the urinary parameter elevation and biochemical serum parameters induced by the evidence. Extract treatment also reversed induced changes in urine volume, pH and Magnesium and creatinine clearance, oxidative and histological damage to the EG-caused kidneys. The histology of treated group showed small and low deposits of calculi in the kidney. Extract showed potential calcium oxalate crystal formation, diuretic, antioxidant activity and preserving the balance between stone promoters and inhibitors. This validated study rationalized its medicinal use in urolithiasis.
Perceptions on continuity of Cardiovascular patient care by Institutional and Community Pharmacists
Authors: Alblooshi Shaima , Thomas Dixon , Zachariah Seeba
Published: October 2023

Background: The role of pharmacists in the continuity of care for patients with heart diseases has not been well studied. In this research, the objective was to explore and evaluate the perceptions of continuity of care for cardiovascular patients by institutional (pharmacists working at pharmacies of hospitals/clinics/health centers) and community pharmacists. Hypotheses were tested to see if there were significant differences in the perceptions of both pharmacist groups on five key dimensions of heart care continuity. Methods: A survey was conducted involving community and institutional pharmacists caring for patients with heart diseases. The targeted sample size was 148 community pharmacists and 148 institutional pharmacists. This was a cross-sectional analytical study. Elements of comparison wereawareness of their medication, patients’ familiarity with safety and benefit of medication, concern about self-care of patients, satisfaction with care received by patients, and access of patients to pharmacists. Descriptive and inferential statistics (i.e., median and Mann-Whitney U tests) were conducted to analyze the data. Results: A total of 240 community pharmacists and 183 institutional pharmacists filled out the survey. The findings of this study showed that there were no significant differences in the perceptions of community and institutional pharmacists on four of the five dimensions of heart care continuity of their patients – perceived awareness of their patients on their medications, satisfaction of their patients with care received, level of concern on their patients' self-care and level of familiarity their patients have on the safety and benefits of their medications. Difference in the perceptions between community and institutional pharmacists on the level of access their patients have to pharmacist services was with a p-value of 0.001. Conclusion: Findings of this study identified “access to the pharmacist” as an area to be studied further between community and institutional pharmacists. Similar perceptions of community and institutional pharmacists showed they were positioned with common opportunities to participate in the continuity of care of patients with heart diseases.
Assessment of Vitamin D, Calcium, Cholesterol, and Phosphorus status in Obese and Overweight patients in Kenitra city (Morocco)
Authors: Baataoui S. , Chakit M. , Boudhan M. , Ouhssine M.
Published: October 2023

Obesity and vitamin D deficiency have both been identified as major public health problems around the world. Overweight and obesity can cause many complications, including cardiovascular complications, but can also disrupt phosphocalcic metabolism, the objectives of our work are first of all: To write the phosphocalcic profile, the lipid balance as well as the dosage of vitamin D in an obese and overweight population, and to understand if the insufficiency in vitamin D is a cause or consequence of obesity. This is a descriptive cross-sectional study. It took place at the Mimosas Kenitra, Medical Analysis Laboratory for 18 months. The population concerned includes subjects Men and women aged between 20 years and 70 years who have BMI (Weight/height2)>25. Patients who are morbidly obese present a vitamin D deficiency of 60%, while 30% of obese patients with vitamin D deficiency were normal. The work of this thesis evaluated the phosphocalcic balance as well as the concentration of vitamin D.
Preclinical Evaluation of hydroalcoholic extract of Moringa oleifera leaves for its Cardiotropic activity on albino Wistar rat
Authors: Das Hira , Majumdar Mrityunjoy , Roy Sourav , Roy Prodip , Singh Shristi , Mondal Sohel , Das Asmita
Published: October 2023

Object Moringa oleifera has numerous medicinal values and uses worldwide. Moringa oleifera is applied to remedy numerous diseases like malaria, arthritis, parasitic diseases, typhoid fever, swelling, cuts, and diseases of the skin, diabetes, and hypertension. However, no scientific evidence is available about the cardio-tropic activity of Moringa oleifera. The current research was carried out to investigate the cardio-tropic activity of hydro-alcoholic extract of Moringa oleifera leaves on the isolated heart of the Albino Wistar rat. The Moringa oleifera leaves were collected, washed, shade dried, and extracted with 70% ethanol. A stock solution (100µg/ml) was prepared by using distilled water. The cardio-tropic activity was screened on the isolated rat heart at a dose of 0.1ml, 0.2ml, and 0.4ml of 70% ethanolic extract of the Moringa oleifera leaf. Acetylcholine (0.0125ml, 0.0250ml, 0.0500ml, 0.1000ml) and adrenaline (0.05ml, 0.1ml, 0.2ml, 0.4ml) were used as standard drugs. Also, on the isolated rat heart, the dose-response curve of 70% ethanolic extract of the Moringa oleifera leaf and the standard drugs were screened at the above same dose. The 70% ethanolic extract of Moringa oleifera leaf (100µg/ml) has produced significant negative cardio-tropic activity as compared to standard drugs. The study indicates that 70% ethanolic extract of Moringa oleifera leaf shows substantial negative cardio-tropic activity on the isolated rat heart in dose dependent manner.
Pharmacokinetic screening to Estimate the drug likeliness characteristics of selected Herbal Anticancer Drugs
Authors: Singh Manish , Kumar Brijesh , K Singh Alok , Shekhar Azad Chandra , K Yadav Mukesh , Kumar Ashutosh , Kumar Rajesh , Kumar Ajay , Chaudhary Pritee
Published: October 2023

The pharmacokinetic parameters of a drug plays a very essential role in determining the therapeutic success of an experimental compound, so it is one of the aspects of drug discovery which are essential to be determined in the early phases. The pharmacokinetic studies further help the drug discovery team to optimize their in vivo pharmacokinetic and drug safety bioassays.Low solubility, low absorbency, and chemical instability can seriously affect bioassay results. Today a lot of computational software are available which use their algorithms to calculate the pharmacokinetic parameters of the selected compounds and hence may help the drug discovery team to move in a direction where the chances of getting a good clinical candidate are higher. This paper presents the screening of nine selected herbal anticancer agents (Catechin, Cinnamaldehyde, Epicatechin, Eugenol, Oxyresveratrol, Quercetin, Crocin, Kaempferol, and Emodin) based upon their pharmacokinetic properties with the help of Discovery Studio 2.5. The main parameters which are estimated under this pharmacokinetic ADMET (absorption, distribution, metabolism, excretion and toxicity) study are aqueous solubility, human intestinal absorption, plasma protein binding (PPB), blood-brain-barrier (BBB) penetration, cytochrome P4502D6 inhibition and hepatotoxicity levels. Four compounds (Cinnamaldehyde, Eugenol, Crocin and Oxyresveratrol) were found to possess the required pharmacokinetic properties and are suitable for further anticancer in vivo and in vitro analysis.
Design, Synthesis, Chemical Characterization and In-vivo Screening of Prodrugs
Authors: Krishna Gaurav , Shah Kamal
Published: October 2023

Ketoprofen is the non-steroidal anti-inflammatory drug which is a propionic acid derivative and is a non-selective COX-inhibitor. It is frequently used in case of osteo and rheumatoid arthritis and other inflammatory conditions. This drug having side effect of gastric ulcer which occur due to free carboxylic acid group present in its structure. Here, we synthesized the ester linked prodrugs of ketoprofen conjugated with different phytophenols. All the synthesized chemical entities were characterized by IR-spectroscopy, 1H-NMR, 13C-NMR and mass spectrometry. All the prodrugs showed significant analgesic and anti-inflammatory effect and less ulcerogenic potential.
Study comparing the effect of topiramate and pregabalin on learning and memory with phenytoin in albino rats using morris water maze and elevated plus maze
Authors: Sulabh Gira , Kumar Vinod , Sulabh Shweta , Verma Veena , Ahmad Absar
Published: October 2023

Epilepsy is a chronic neurological disorder characterized by repeated seizures. Neurocognitive impairment is one of the adverse drug reactions (ADRs) in the case of antiepileptic drugs (AEDs). Phenytoin (PHT), an effective older generation AED, shows decline in cognitive functions such as memory, concentration and motor speed in both healthy volunteers and epileptic patients. Topiramate, has cognitive complaints among the adverse effects reported and include impaired concentration and memory, slowing of thought process, and difficulties in word finding. Another antiepileptic Pregabalin shows that it’s negative effects on cognitive functions are mild. Hence, a comparative assessment of the above group of drugs along with a control group was done using morris water maze and elevated plus maze. Effects on learning and memory was assessed using parameters such as escape latency and transfer latency. Albino rats were taken (24 in number) and assigned into 4 groups with three drug groups and one control group. They were given the respective drugs for a period of 15 days and then checked for escape latency and transfer latency times to assess the effect on “learning”. Thereafter the rats received the drugs for another 5 days after which they were assessed for “memory”. It was seen that phenytoin and topiramate do affect learning in comparison to pregabalin but the result about affecting memory was not conclusive.
Digital transformation in global higher education: A review of literature and implications for Vietnamese universities
Authors: Pham Thi To Loan
Published: October 2023

Digital transformation in higher education has become a common trend in the pursuit of a sustainable education system in the future. This trend fosters higher education institutions to implement teaching, learning and research activities in an innovative and creative way. Globally, universities are making efforts to boost digital transformation application as a way to maintain their competitive advantages. This literature review aims to discuss digital transformation in global higher education, elaborate types of digital transformation, digital transformation frameworks for universities and put forth implications for Vietnamese higher education. It is hoped that this paper will provide insights into digital transformation in higher education in the world so that educators, policy makers and university leaders can collaborate and take proper actions to enhance the effectiveness of digital transformation application.
Developing student's self-study capability through models for readers at Le Vu Hung Resources Center, Dong Thap University
Authors: Nguyen Thi Nhu Quyen
Published: October 2023

The article is the result of the author's research on developing students' self-study ability through models and activities initiated by Le Vu Hung Resources Center. The author uses a practical survey among students at Le Vu Hung Resources Center. Based on that, the paper proposes measures to develop their self-efficacy through the operation model of the library. The article adds a theoretical framework for developing self-study capacity for university students and the measures applied at Le Vu Hung Resources Center. This is an important factor in assessing and improving the quality of education and training in schools.
STEM products of mechanical subjects making water fire model
Authors: Pham Thiet Truong , Ha Thai Thuy Le
Published: October 2023

STEM education has been long implemented in high schools and junior high schools in Dong Thap province in general and Cao Lanh city in particular. On the basis of the classification of STEM, the paper aims to present its role  and needs in teaching to improve students' skills in applying interdisciplinary knowledge. It is very necessary to apply an effective combination of learned theories and knowledge to solve real-life problems in order to consolidate, improve knowledge and help students develop their character either creativity problem solving or subject-specific competencies. This article surveys students' understanding of STEM summaries of knowledge related to the "Mechanics" section and details on how students apply STEM product design processes from scratch implementation plan to the design and presentation of their "Water Rocket Model" product as well as their actual product.
Measures to build material environment for children aged 5-6 to discover science at kindergarten schools in Lap Vo district, Dong Thap province
Authors: Tran Nguyen Thi Nhu Mai , Dao Thi Bao Tran , Cao Huyen Hao , Nguyen Thuy Diem
Published: October 2023

Building a physical environment for children to explore science is an extremely important task in the process for preschool education goal, towards developing their cognitive capacity by experiencing the surrounding environment in various forms. This also helps to meet their needs and interests under the motto "learning by playing, playing through learning", promoting all potentials and personalities. The article mentions the concepts of the physical environment, the principles of building a physical environment for children aged 5-6 to explore science and points out the difficulties in this task. The article also proposes measures to build the target environment, such as: promoting real local conditions; closely coordinating with young families; choosing toys based on children's interests and promoting children's ability to make toys.  These measures will contribute to improving the effectiveness of the design of the physical environment for children in scientific discovery activities.
NUMERICAL INVESTIGATION OF NATURAL CONVECTION IN A RECTANGULAR CAVITY BY CFD CODES
Authors:   Kayseri University Bünyan Vocational School, Türkiye, ÖZRAHAT Evrim , TOPRAK Mehmet ,   Erciyes University, Institute of Sciences, Kayseri, Türkiye, ÜNALAN Sebahattin ,   Erciyes University, Engineering Faculty,Kayseri,Türkiye
Published: October 2023

In this study, natural convection in an air-filled rectangular cavity is studied numerically by two commercial CFD codes. Numerical simulations are carried out for air and water for different aspect ratios and wall temperatures. Calculations are compared with experimental correlations in the literature and with each other. Calculation time and mesh number are the main parameters considered in this study. According to the numerical results, SIMCENTER FLOEFD is an effective CFD code as ANSYS FLUENT and gives accurate results for this type of problem.
Polski model prowadzenia śledztw w sprawach oszustw podatkowych popełnianych metodą karuzelową
Authors: Lebiedowicz Andrzej
Published: October 2023

This article is devoted to an analysis of the Polish model of conducting an investigation in cases of tax fraud committed with the carousel method, clearly indicating the superiority of the offensive (dynamic) type over the static (conservative) type. It concerns the economic evolution of an organized crime and discusses the carousel mechanism, raising the issue of carousel crimes and their legal qualification. The article presents the main features of a dynamic and static model through the prism of specific goals facing investigators in this type of case. Finally, it presents selected methodological guidelines aimed at the most extensive possible implementation of the model of conducting an investigation preferred due to the level of activity in cases of tax carousel fraud.
Deepfake jako narzędzie do przekazywania informacji fałszywej i domniemanej. Analiza prawno-karna i cybernetyczna
Authors: Kiełpiński Krzysztof
Published: October 2023

Since 2017, the phenomenon of deepfake has emerged online. It has very quickly been applied to various areas of human life. The developing digital world, social media, entertainment and other areas have brought the exchange of information between people online. There is a lack of monographs and articles in the Polish and foreign-language literature that would reliably describe this type of threat in the virtual world. The essence of the deepfake phenomenon was to transmit false or assumed information, which is done by means of photographs or videos. In most cases, it is not possible to verify the authenticity of the material. Deepfake technology has specific types that make users of the web and many applications unaware of this type of threat. The article describes the deepfake phenomenon as a tool for conveying false and implicit information. The analysis of the phenomenon was carried out in two dimensions: legal-criminal and cyber-criminal. A number of research methods have been used, including dogmatic-legal, historical, comparative, philological and historical. Amongst numerous conclusions, the most important one indicates that deepfake is a new form of manipulation and disinformation. This type of technology makes it possible to commit many crimes, which are difficult to prove to the perpetrator during criminal proceedings. The cooperation of many state institutions, non-governmental organisations, software or application manufacturers will help to win the fight against this type of phenomenon.
Przemoc domowa. Uwagi definicyjne i systemowe.
Authors: Piekło Beata
Published: October 2023

The purpose of the article is to analyse and explain the concept of domestic violence, demonstrate the complexity of the problem and examine the system for protecting victims of violence and for counteracting violence. The text also presents the legislative changes made to the Act of 29 July 2005 on Counteracting Domestic Violence and discusses the solutions introduced.
Every one counts: A retrospective cohort study examining the safety of extending pre-transfusion compatibility testing from 72 hours to 7 days in hematology patients receiving red blood cell transfusions
Authors: Ambrose Harriet , Hedrick Ashlee , de Leur Marcus , Elton Georgina , Evans (Bruce) Alicia , Mullen Rebecca , Rowlings Philip , Ross Bryony , Prasad Ritam , K Enjeti Anoop
Published: October 2023

Aims: To investigate the safety of extending the pretransfusion compatibility testing (PTCT) interval from 72 hours to 7 days in hematology patients receiving packed red blood cells (PRBC).

Methods: We undertook a retrospective cohort study over two years when the local protocol for PTCT in recently transfused hematology patients was changed from 72 hours to 7 days. All transfusions from 12 months prior and post this date were exported from eBlood and analyzed. The primary outcome was the incidence of transfusion reactions. Subgroup analysis was conducted for the chronically transfused patient group and patients with PTCT > 72 hours.

Results: A total of 2079 packs were analyzed from 227 patients. Only 37 transfusions that fulfilled the extended crossmatch. There were five (0.69%) transfusion reactions within the post-protocol change cohort and no transfusion reactions in the pre-protocol change cohort. All transfusion reactions occurred in the greater 72-hour subgroup of the post-protocol change cohort. At the time of reaction, there were no alloantibodies identified. No patients demonstrated new alloantibodies post-reaction.

Conclusion: This study found no evidence for an increased risk of transfusion reactions associated with increasing the PTCT interval from 72 hours to 7 days in a subset of chronically transfused hematology patients. Extending the PTCT interval could decrease costs, decrease patient infection risk, improve comfort, and conserve public health resources. Further evaluation in a larger cohort is necessary.
THE EFFECTIVENESS OF MANAGEMENT OF SOCIAL PROBLEMS OF BEGGERS, VARIETIES, AND INDEPENDENT PERSONS IN CENTRAL JAVA SOCIAL SERVICES
Authors: Lalu Satria Utama  , Ridwan Ainun Firdaus  , Syaefullah Syaefullah
Published: October 2023

The Unemployment, Homeless, and Abandoned Persons (PGOT) in Central Java Province in the period 2020-2021 has decreased but what happened at the PGOT Social Service Orphanage Mardi Utomo repeated that PGOT had received training back into the orphanage because they could not be independent. The purpose of this study was to determine the effectiveness of PGOT management in Central Java through the Social Service of Central Java Province. This study used a qualitative descriptive research method through direct interviews with ASN in the Social Service and Mardi Utomo PGOT Social Service Institutions. The results of the research, social rehabilitation efforts at the Mardi Utomo Home are still not maximized, as a result beggars, homeless people and abandoned people in Central Java Province even return to the streets & decide to return to the orphanage so that their lives are guaranteed by the state when coaching in the orphanage
THE INFLUENCE OF PRODUCT DEVELOPMENT AND MARKETING COMMUNICATION ON INCREASING SALES VOLUME IN PT. GLOBAL UGGUL MANDIRI – PAXEL HEAD OFFICE, JAKARTA
Authors: Martha Ayerza Esra
Published: October 2023

The increase in sales volume is very important for a company development. Companies use all techniques to increase sales volume, from creating new products that meet consumer needs to marketing communications. With direct or indirect marketing techniques to introduce products that are owned by the company. In the current era, there are many ways to conduct marketing communications, one of which is with technology-based social media. This research was conducted using survey data methods, based on product development data, marketing techniques to the desired result in the form of volume increase.