bluuebunny/crossref_metadata_2025 huggingface dataset:
The use of drug monitoring of infliximab and adalimumab to optimize the treatment of inflammatory bowel diseases in children
Authors: Radygina Tatiana V. , Illarionov Alexey S. , Petrichuk Svetlana V. , Kuptsova Darya G. , Kurbatova Olga V. , Fisenko Andrey P. , Potapov Alexander S. , Semikina Elena L. , Anushenko Anton O.
Published: November 2022

Introduction. The effectiveness of the use of TNF inhibitors in patients with inflammatory bowel diseases (IBD) has been shown. 20-40% of patients are known to fail to respond to received therapy, and 10-30% of patients experience a loss of effect by the year of therapy. Objective is to evaluate the information content of therapeutic drug monitoring (TDM) for effective treatment with TNF blockers (infliximab - IFX, adalimumab - ADA) in IBD children. Materials and methods. There were examined seventy four children on IFX therapy including 66 children on ADA therapy. The age of the children ranged from 3.4 to 18 years. Residual levels of IHF and ADA were determined using a lateral flow immunoassay. Statistical data processing was performed using the Statistica 10.0, SPSS 16 software. Differences between groups were assessed using the nonparametric Mann-Whitney U test. Results. IFX levels (less than 3 µg/ml) were detected in 64% of cases, ADA (less than 5 µg/ml) in 21% of cases. The residual level of IFX and ADA in remission significantly exceeded the level of drugs in groups of children in exacerbation. An inverse relationship was observed between the residual level of IFX (r = -0.68, p = 0.000) and ADA (r = -0.31, p = 0.000) and the number of days after drug administration. Anti-IFX antibodies were found in 27.3% in the exacerbation group and in 5.8% in remission (p < 0.001). Antibodies to ADA in children with IBD were found in 4 patients with a low concentration of the drug (2.57 ± 0.45 µg/ml) in the serum in a state of exacerbation. In patients on anti-TNF therapy, empirical dose selection revealed a residual level lower than in children in whom dose adjustment was carried out taking into account the residual concentration of drugs. Conclusion. The use of TDM TNF blockers in combination with the determination of antibodies to drugs can significantly increase the effectiveness of therapy in IBD children.
Magnetic resonance imaging in acute traumatic injuries of ligaments and soft tissues of cervical spine in children
Authors: Bozhko Olga V. , Akhadov Tolibzhon A. , Ublinsky Maksim V. , Meshcheryakov Semen V. , Manzhurtsev Andrey V. , Melnikov Ilya A. , Semenova Natalya A. , Dmitrienko Dmitriy M. , Khusainova Dariya N.
Published: November 2022

Aim of the study: to study the role and possibilities of magnetic resonance imaging (MRI) in the diagnosis of injuries of ligaments and soft tissues of the cervical spine in emergency care. Materials and methods. MRI was performed in fifty two children with trauma of the cervical spine, in 1 of them with contrast enhancement. Boys predominated - 33 (63.5%), girls were 19 (36.5%). The age of the patients varied from 3 to 17 years, the mean age was 14 ± 1.4 years. The study was carried out on a Phillips Achieva dStream 3T scanner. The study protocol includes MR-myelography in sagittal and coronary projections, T2WI sagittal projection in PS STIR, T2WI SE, T1WI SE, DTI, axial projection of T2WI SE or T2*WI GRE. Results. Trauma of cervical spine was combined in 46% (n = 24) of all 52 cases, and in 54% (n = 28) it was isolated. During the clinical and neurological examination according to the ASIA impairment scale, there were 13 (25%) children with grade A, 3 (5.8%) with grade B, 9 (17.3%) with grade C, 4 (7.7%) with degree D and 23 (44.2%) with grade E. Spinal cord injuries in the form of hematomyelia were detected in 13 (25%) children, contusion and swelling of the spinal cord - in 15 children (29%). According to MRI results, 4 (7.7%) had a traumatic hernia with a decrease in disc height, 15 (28.8%) had secondary stenosis of the spinal canal at the time of the study, 28 (53.8%) had spinal cord compression and changes in the MR signal, 5 (9.6%) had epi- and subdural hematomas, 45 (86.5%) had vertebral fractures. Conclusion. MRI, as a method more sensitive than other imaging modalities in the diagnosis of soft tissue and spinal cord injuries, allows radiologist directly assessing the condition of spine soft tissues and, therefore, is critical in the evaluation of a patient with ligament injury and instability. Recognition of soft tissue injuries affects patient management and outcome.
Successful experience in the use of teduglutide in children with short bowel syndrome
Authors: Tropina Elena P. , Zmanovskaya Vera A.
Published: November 2022

The article presents an overview of current trends in the approach to the treatment of patients with short bowel syndrome (SBS), including the example of pediatric patients in the Tyumen region. SBC is an extremely rare nosological form in the practice of a clinician and, as a rule, patients with such a diagnosis require a multidisciplinary approach. The most common manifestations of the disease are symptoms of malabsorption: dumping syndrome, progressive weight loss, deficiency of macro- and micronutrients, other manifestations of dyspepsia and abdominal pain. Attention is drawn to the fact that the number and intensity of symptoms varies significantly among patients. The traditional tactic for treating such patients includes the need for lifelong parenteral nutrition or, as a necessary measure, intestinal transplantation. Rehabilitation measures in SBS children should take into account the requirements for correcting impaired absorption and restoring normal trophic status; relief of diarrhea, prevention and treatment of dysbiosis; control and correction of general digestive disorders. We found that the analogue of glucagon-like peptide 2 (GLP-2) - teduglutide - makes it possible to reduce the amount of parenteral nutrition, infusion time, and also achieve a complete transition to enteral autonomy. The method of treatment with Teduglutide is the most promising for patients of this category.
Features of determining the diffusion capacity of the lungs by carbon monoxide in cystic fibrosis children
Authors: Bystrova Serafima G.
Published: November 2022

The article presents current literature data from English-language (search made in PubMed) and Russian-language (search made in eLibrary) sources about the method for measurement of the lung diffusing capacity for carbon monoxide in children with cystic fibrosis (CF). This review presents the general characteristics of this test in children and adults with various diseases, and also describes the conflicting results of studies using this method in CF patients of various ages and disease severity. The expediency, the informativeness, and difficulties of evaluation and interpretation of the test’s results, depending on the age and course of the disease of patients, are discussed. The author concludes that further research of interpretation of indicators determined during the test of the lung diffusing capacity for carbon monoxide, such as the transfer factor, alveolar volume, and their ratio in CF children is necessary.
Electronic cigarettes (vapes) are an old threat to health in a new guise
Authors: Galitskaya Marina G. , Fisenko Andrey P. , Makarova Svetlana G.
Published: November 2022

Electronic nicotine dosing systems, commonly known as electronic cigarettes or vapes, have quickly become the most common tobacco products used by teenagers and young people, largely due to the marketing and advertising of the companies that produce them. The appearance of nicotine-free vapes is a new round in the production of electronic cigarettes. Due to the widespread opinion about the harmlessness of such vapes, they are increasingly being used by children and adolescents. The review describes the composition of vaping aerosols, provides data from scientific research on their impact on human health. The danger of smoking both nicotine and nicotine-free vapes is shown. However, given the relative short duration of the use of electronic cigarettes, there are many both purely medical and legal questions. All these issues require further research, which continues all over the world. The authors recommend being wary of this habit and the newfangled hobby of teenagers and young people, applying knowledge about the dangers of vaping in everyday practice, which will indirectly help children and adolescents avoid the path of nicotine addiction, protecting the health of the younger generation.
Actual problems of philosophy of health in the context of bioethics
Authors: Ivanyushkin Aleksandr Ya. , Ivanyushkin Ivan A. , Smirnov Ivan E. , Lyaush Lev B.
Published: November 2022

The review discusses the content of the concept of health in scientific and philosophical discourse. Taking into account the correlation of the subjects of clinical, preventive and social medicine, the historical stages of studying the problem of the health of the person (individual) and public health are briefly described. The content of the concept of health is revealed in accordance with the concept of B.G. Yudin in three dimensions: as a fact, norm and value. A methodological analysis of the definition of health in the WHO Constitution is given. The issue of legal correctness of Part 1 of Art. 27 of the Federal Law “On the Fundamentals of Protecting the Health of Citizens”. The problems of the philosophy of health are covered in the context of bioethics, the relevance of ethical control and health care is emphasized. The review defines the guidelines for the coverage of some problems of the philosophy of health in teaching in the system of domestic medical education.
A Comparison of Open Sun Drying Using Tomatoes and Mixed Mode Type Solar Drying
Authors: Krishna M. Jaya , Teja V. Ravi , Deepthi M. , Ganesh Ch. , Lokesh R.
Published: November 2022

Ingredients utilized in many culinary products, such as dried tomatoes used to make tomato powder and also used in sandwiches, are made via solar drying. When compared to damp products, dried items are more expensive. Used in various sectors, such as drying floor mats, in addition to drying food goods. Compared to drying in the open sun, solar drying produces superior outcomes. We also examine the temperature change and moisture decrease rate between solar drying and open sun drying. Solar drying was created to address some drawbacks, including dust, unpredictable temperature, and pollution. In these, we carry out an experiment in which we contrast solar drying with drying in the open sun. We can maintain the necessary temperature and shorten the drying period by employing solar drying. Solar drying was used to produce a high-quality product. For best results, we employed mixed mode type solar drying on them. Climate, ambient air temperature, solar air heater temperature, dryer chamber temperature, kind of food material, and atmospheric moisture all have a significant impact on the process.
La necesidad de despenalizar la eutanasia en el Ecuador
Authors: Inga Paredes Diego Paúl , Ciruzzi María Susana
Published: November 2022

En este artículo se realizó un análisis sobre la muerte asistida (eutanasia) y la necesidad de su despenalización, teniendo en cuenta el principio de autonomía de la voluntad, mediante una visión bioética y jurídica de la problemática. El presente análisis se desplegó aplicando métodos analítico y sintético, inductivo y deductivo, y dogmático, mediante un enfoque cualitativo, realizando una profunda revisión de varios autores que tratan el tema, es decir valiéndonos de técnicas de revisión de bibliografía relevante sobre el tema. Luego del estudio crítico se justificó que en el Ecuador es necesaria la despenalización de la eutanasia de una persona en determinadas circunstancias, pues si la persona se está enfrentando a un proceso doloroso que le ha acarreado daño, es normal que tome una decisión sobre las circunstancias y modo en las que quisiera dar fin a ese sufrimiento, y el Estado debería garantizar este derecho. Adicionalmente, se consideró que resulta indispensable una reforma a la normativa interna del país, ajustándose a parámetros internacionales.
Analysis of the Role and Performance of Business Incubator al-Ahmadi Entrepreneurship Center Batam Riau Island
Authors: Khairiyah Muthi'ah , Fitri Atiyah , Triyanto Abdi
Published: November 2022

This study aims to determine the performance of the Al Ahmadi Entrepreneurship business incubator in assisting the fostered businesses. Knowing the benefits of the incubation program on the performance of the fostered business. The method used in this research is descriptive quantitative. The data used in this study are primary and secondary data. The primary data was obtained from questionnaires distributed to the fostered business incubators, while the secondary data came from literature studies sourced from books, journals, reports or previous research. The data obtained were analyzed using the Balanced Scorecard (BSC) method. The results showed that the achievement score of Al-Ahmadi Entrepreneurship Center's performance was 82,127. According to Price Waterhouse Coopers Al- Ahmadi Entrepreneurship Center in mentoring fostered businesses is satisfactory. Al-Ahmadi Entrepreneurship Center has played a role in improving the performance of the fostered businesses seen from four indicators, namely increasing turnover, increasing the number of workers, increasing production capacity, and increasing access to sources of capital.
The effect of the covid-19 pandemic on sales in kemanggisan slipi market, West Jakarta
Authors: Luthfiyyah Atikah , Fitri Atiyah
Published: November 2022

This study aims to: examine the effect of the COVID-19 pandemic on sales. This research is a quantitative study using a simple linear regression method which in all tests uses the SPSS v.25. Data was obtained by distributing questionnaires directly and interviews with businesspeople in the Slipi Kemanggisan Market and a total sample of 72 respondents. Measurement of the COVID-19 pandemic is seen with the indicators of Large-Scale Social Restrictions (PSBB) and Social Distancing. The result proved that the COVID-19 pandemic affects sales at the Slipi Kemanggisan Market. This is obtained from the results of the t-value which is greater than the t-test.
Maqashid Sharia Analysis of Change From Customers for Donation: a Case Study in Fajar Toserba, Jalaksana District
Authors: Syafi'i Alfan , Dewi Ega Kusuma
Published: November 2022

The Qur'an and Islamic legal literature do not mention the word Islamic law as one of the terms in the Qur'an is the word syarî'ah, fiqh, Allah's law, and the same root with it. The term Islamic law is a translation of Islamic Law in western literature. If traced to its roots, then the meaning of Islamic law is "control or bridle of the horse", what is meant here is that in essence the law exists to regulate people who are subject to the law itself. Other meanings derived from the root word hakama include preventing injustice, preventing tyranny, preventing persecution, and rejecting other mafsadat. The research on Maqashid Syariah analysis of the ask foral of change for donations (a case study in Fajar Toserba, Jalaksana District) aims to understand how the practice of asking for change for donations is, how the distribution of these donations when they have been collected, and how Muqashid Syariah analyzes the practice of asking for change for donations. donation. This study uses a descriptive qualitative method because it describes the data in the form of a written description. Types and sources of data in this study using primary and secondary data. Data collection techniques through interviews and observations. The results of this study are on the ask foral of change for donations at Fajar Toserba Jalaksana when buying and selling transactions. As for the practice, when buying and selling at Fajar occurs, if there is odd nominal money, it is directly distributed to the social fund in the payment receipt. Maqashid Sharia analysis on this matter can be concluded that the five main points or al-mabaadi 'al-khamsyah have been fulfilled. customers for change for donations and distributing the donation money have fulfilled the purpose of Islamic law itself, namely Maqashi Syariah. Although there are elements that should not be done, in this case, the benefits are greater.
Problems of mortality analysis in towns of the Russian Federation
Authors: Saltykova MM , Antipina UI , Balakaeva AV
Published: November 2022

Mortality rate is one of the main indicators of how healthy a population is, and planning and implementing measures aimed at reducing morbidity and increasing life expectancy in the population is impossible without an adequate analysis and interpretation of mortality data. At the same time, as pointed out by many researchers, there are factors external to a human body being that can have a significant effect on the mortality rate in a population. This study aimed to assess the impact of one of these factors, the number of beds in hospitals (per 10,000 people) of cities with population exceeding 100,000 people. The analysis included data from Rosstat (Russian statistics service) on the population size, mortality, number of hospital beds, average monthly wages in 12 cities within the period from 2017 through 2019. Five cities from these 12 were selected as a more homogeneous subgroup in terms of socio-economic conditions. We found a positive correlation between mortality rate per 1000 inhabitants (R > 0.7; p < 0.009) and the number of hospital beds per 10,000 people in the sample of 12 cities. This correlation was higher (R ≥ 0.9; p < 0.037) in the more homogeneous subgroup. A factor that may condition this correlation may be that of deaths of people from other regions in hospitals of the cities in question, which are counted when estimating the mortality rate and have a significant effect on that estimation. The results of the study point to the need to differentiate between people registered in a city and those living there permanently when assessing mortality rate therein.
Tahap Kecerdasan Emosi Guru-Guru Sekolah Antarabangsa di Kuala Lumpur: Satu Kajian Kes
Authors: Syed Yahaya Sharifah Munirah , Azman Norzaini
Published: November 2022

Kajian ini bertujuan untuk mengkaji tahap kecerdasan emosi dan hubungan di antara kecerdasan emosi dan demografi (jantina, umur dan bangsa), pengalaman mengajar, tahap pendidikan dan kelayakan mengajar (guru yang memiliki sijil mengajar) bagi guru-guru di sebuah sekolah antarabangsa di Kuala Lumpur. Kajian ini adalah kajian kes jenis tinjauan berbentuk kuantitatif dan menggunakan instrumen Inventori Kepintaran Emosi Malaysia (IKEM) yang dibina oleh Noriah et al. (2004). Seramai 47 orang guru sekolah rendah telah menyertai kajian ini. Statistik deskriptif digunakan bagi melihat tahap kecerdasan emosi manakala Ujian-t digunakan untuk melihat hubungan di antara kecerdasan emosi dan jantina serta kelayakan mengajar. ANOVA Satu Hala pula digunakan untuk melihat hubungan bagi pembolehubah-pembolehubah yang lain. Dapatan kajian menunjukkan bahawa tahap kecerdasan emosi guru berada pada tahap yang tinggi. Kajian ini juga mendapati bahawa tidak terdapat perbezaan yang signifikan di antara kecerdasan emosi dengan jantina, umur, bangsa, tahap pendidikan dan kelayakan mengajar. Namun, terdapat perbezaan yang signifikan di antara kecerdasan emosi dan pengalaman mengajar. Kajian ini memberi implikasi bahawa pengalaman mengajar adalah elemen penting dalam membentuk kecerdasan emosi guru.
Services of the Ilocos Sur Polytechnic State College Graduate School: Basis for an Improvement Plan
Authors: Absolor Jocelyn L.
Published: November 2022

The academic journey of the graduate students in every Higher Education Institution(HEI) can be fortified by allowing them experience quality services. This study assessed the students’ level of satisfaction on the services of the Graduate School of Ilocos Sur Polytechnic State College along professional services,school facilities,and learning environment. It further determined the profile of the respondents in terms of age,sex,civil status, position, employment status, number of years in teaching and type of school employed in.The profile was correlated to their level of satisfaction.The weaknesses of the services were identified as basis in the development of an Improvement Plan.The study is a descriptive research employing correlational and developmental methods.A sample size of 120 graduate students were selected randomly with a questionnaire as an instrument in obtaining data that were treated using frequency count and percentage,simple bi-variate correlation, and  Cronbach Alpha. The profile revealed that the respondents are of varying background.The respondents are highly satisfied with the three identified services. Years of teaching is a determinant  of satisfaction on professional services while position  show significant effect on their satisfaction on school facilities and learning environment.The accessibility of books and computers in the library and dormitories were identified as areas that require improvement.
Medical Ethics and Women Role in Robin Cook’s Coma and Fatal Cure
Authors: Shawawreh Aysheh , Bani-Khair Baker
Published: November 2022

Medical ethics are quite an essential and prevalent thematic issue in most of Robin Cook's novels. However, Robin Cook in his novels, Fatal Cure(1993) and Coma(1977) has presented a tremendous interest in the human ethical side which both novels constantly show in almost every single page. Robin intentionally brings contrasting images to show the importance of those roles that women play in medical professions. Ethics are the main drive towards any development, however, the two novels proposed a systematic approach in dealing with medical ethics by highlighting the focus on the frequent violation of ethical and moral law which are usually committed  by  psychologically  disturbed individuals  and  psychopaths. This paper sheds light on the role that women play and the challenges they face to encounter and overcome those burdens in medical professions.
Tragedy according to Plato's critical opinion
Authors: Kastrati Nexhmije
Published: November 2022

The ancient Greek world gave world literary philosophy great names such as Plato, Homer, Aeschylus, Sophocles and others who revolutionized the art of writing and told it the idea of critical thinking, on the forms, styles and skills of making art generally. In ancient antiquity these attitudes were primary, and it was almost impossible for the writings to break away from the tradition, which at its core was dominated by tragedy, as one of the formats that would later dominate the entire globe as a source of inspiration. Man seems to need to experience loss, suffering and tragedy, perhaps to appreciate the love and spirit that it (life) gives. Therefore, in this paper, the types of dramatic works are taken for analysis, in particular the tragic and the tragedy according to the critical opinion of Plato, and the development of this field in old Greece, with the most famous authors Aeschylus and Sophocles and with Shakespeare in Europe. A special space in this study is occupied by Plato's criticism of Homer, to whom he even asked special questions, because, as is known, Plato in his theory on the state was looking for a literature, an art that would have educational effects on young people ...as well as the theoretical problems that characterize tragedy, the hero and heroism and other feats, and the writing style within the literary narrative.
Delphi technique between the easy theoretic and the difficulty application in scientific research and future studies
Authors: Amrouche Toumia
Published: November 2022

The application of Delphi technique in scientific studies and future scientific research gave it a great importance according to the efficiency and effectiveness of its results. It is able to find solutions to any research problem by following the methodological steps during its application, starting with the selection of experts and identifying the problem studied carefully to the results or the final report that prepared by the researcher based on the opinions and expert ideas. This technique combines between quantitative and qualitative way. It is based mainly on questionnaires distributed from two to four phases as a maximum, which contain open questions in its first phase and closed ones in the rest of the stages. Through this paper we will try to explain this technique, the steps that are based on it with its advantages, disadvantages and the difficulties of its application with a typical example explaining how to apply them.
Adherence to Treatment in Diabetic Patients in Lebanon
Authors: Yassin Nour
Published: November 2022

Non-adherence to prescribed treatment represents an important dilemma that deserves special attention especially when dealing with chronic and critical diseases as in diabetes mellitus. The objective of this study was to evaluate the level of adherence in Lebanese adult outpatients suffering from diabetes mellitus, where they may present other illness and to identify the possible predictors of non-adherence in this patient group.A questionnaire was administered face-to-face to a sample of Lebanese adults visiting two pharmacies and two endocrinologist clinics. The questionnaire covered the socio-demographics, lifestyle and health status of the patients, regimen characteristics, drug affordability, relationship with healthcare provider, and patients’ attitudes and beliefs. The level of adherence was assessed using the 8-item Morisky Medication Adherence Scale. Statistical analysis was performed using SPSS version 17. Univariate associations between drug adherence and patient and drugs characteristics were tested using chi-square test. Out of the 130 patients included in this study, 64.6% were classified as adherent and 35.4% were not. In the univariate analyses, statistically significant predictors of low adherence included smoking status(p=0.012) , level of stress and anxiety (p=0.009), monthly cost in LL (p=0.049), changing treatment plan a lot recently (p=0.010), taking any acute drugs (p=0.014), forgetting to take their pills (p<0.001), taking their medicine over the past two weeks (p<0.001), cutting back or stop taking their medication without telling their doctor  because they felt worse when they took it (p<0.001), forgetting  to bring along their medications during traveling (p<0.001), stop taking their medicine when they feel that the disease is under control (p<0.001),feeling disturbed taking medication everyday (p<0.001), difficulty remembering to take all their medications (p<0.001).As forgetfulness being the most important reason of patient non adherence, there should be a cooperative work between healthcare providers in order to overcome such a problem where they should create methods that help in educating patients and improving their adherence.
Development and Implementation of Quality Assurance According to GMP Guidelines in Lebanese Pharmaceutical Companies
Authors: Yassin Nour
Published: November 2022

The quality of pharmaceuticals has always been a concern to the World Health Organization (WHO) from the beginning its inception. Good Manufacturing Practice (GMP) is an important part of a comprehensive system of quality assurance (QA) for both manufacturers and the government. In Lebanon, and since its application, many challenges faced the implementation of the QA program according to GMP guidelines. Yet, this program has been successfully implemented in the Lebanese pharmaceutical industry supported by the Lebanese Ministry of Public Health (MOPH), and the commitment of the national GMP committee, in addition to the involvement of the public and private pharmaceutical sectors. The main objective of this study is to evaluate the implementation of the QA program according to GMP guidelines by selected Lebanese pharmaceutical companies. A descriptive analytical study was conducted between August-November of 2018, using a questionnaire that was administered to the quality departments of 10 Lebanese pharmaceutical companies. Finding showed that all these companies were implementing the QA programs according to GMP guidelines (100%), where 60% of their quality managers are experienced in GMP guidelines for more than 6 years. Further, 50% of these companies were applying QA program according GMP guidelines since more than 6 years, and 80% of them are formulating their programs using all the quality tools of the international GMP standards. Moreover, 80% of them are establishing awareness toward the implementation of GMP guidelines through training by internal expertise and external consultants. On the other hand, the implementation cost was the most important challenge faced by 60% of these firms. Finally, all companies are profiting by an increase in efficacy and efficiency, better product quality, and decrease in defects due to the implementation of the GMP guidelines. All the Lebanese pharmaceutical companies are working toward developing their program to meet the international standards, yet, they still need governmental support to spread and compete around the world.
Improving soft skills and hard skills Wagra Learning Package C through the independent education curriculum in the Merdeka Belajar Scheme
Authors: Paus Julduz Ruland , Aditama Mint Husen Raya , Mangantes Meisie Lenny
Published: November 2022

Education is an important component of the life of any member of society. Studying in an educational institution alone is not enough to be successful. There are other supporting skills that can be acquired by the community besides formal education. This is the reason why independent education is an ideal concept in the Merdeka Belajar scheme. The purpose of this work is to learn and apply the principles of self-education that focus on improving the soft skills and hard skills of residents learning package c in the province of North Sulawesi. This goal is achieved through pedagogical experiments carried out at learning activity center institutions (SKB) and community learning activity centers (PKBM), through surveys of the needs of learning civil service practitioners and learning residents at different levels of education. Statistical data on the dynamics of self-education are analyzed through statistical and descriptive methods. The results of measuring the need for soft skills and hard skills found that factors of age, gender, and employment status influenced the choice and lack in improvement of soft skills and hard skills in independent education training. Factors such as leadership, determination, self-control and self-organization, work independence, and work skills became the main foundation in the preparation of the self-education curriculum of citizens learning package C. The factors contained in the self-education curriculum material affect the level of knowledge and increase educational motivation, social interaction and goals, show in the knowledge gained and help apply the approach to learning package C residents. This study shows that an independent education curriculum based on the needs of soft skills and hard skills must be carried out consistently and regularly by non-formal educational institutions. In supporting the Merdeka Belajar Program, the independent education curriculum prepared from this work can be used as a reference for separate education policies in formal education schemes
Between the Past and Future. Antwerp Zoo and the 19th Century Belgium
Authors: Song Zihao
Published: November 2022

Antwerp zoo was established in 1843 under the management of the Zoological Society of Antwerp. As one of the oldest zoos in Belgium and Europe, the establishment, operation and development of Antwerp Zoo are closely related to Belgian society in the 19th century. At the same time, it also reflects the self-awareness of the newly independent Belgians in the face of industrial civilization and exotic nature. This article discusses how the Antwerp Zoo as a public place embodies 19th century Belgian colonial and imperial ideas from perspectives of function, architecture, visitors and animals and the cultural meaning of modern zoos in European continent. Modern European zoos represented by Antwerp zoo are social and educational places dominated by the middle class in the 19th century, and also reflect people’s thought about the relationship between human and nature.
Research on employment support of autistic children in underdeveloped areas
Authors: Chen Yitian , Bi Chuanchen
Published: November 2022

As a neurodevelopmental disorder, autism causes great pressure on the spirit of patients and their families. Since 1982, there are more than ten million autistic children in our country, which has become one of the social topics worth paying attention to. Because of the lifelong nature of autism, it can not be completely cured, which brings a great burden to the family economy. In addition, there are few studies on social support for autistic people in our country, there is also a lack of necessary and in-depth discussion on the employment of children with autism. With the continuous development of our country's economy, the regional social welfare system is well established in the areas with good economic development, and autistic children in these areas can get help through relevant social remedy measures, at the same time, we can not neglect that there are many underdeveloped areas in our country, and the employment of autistic children in these areas has not been effectively and properly solved. In view of the above background, according to my own professional knowledge, through the network questionnaire and offline interviews and other research methods, summed up the current employment support of autistic children in underdeveloped areas of our country, many problems, at the same time, the paper discusses the specific reasons of the relevant problems in a deep level, and finally, on the premise of combining the reasons of the problems and referring to more academic literature, this paper puts forward some pertinent and feasible suggestions and countermeasures on how to effectively solve the employment support problem of autistic children in underdeveloped areas, so as to provide reference for relevant practitioners and social researchers.
External envelope impact on thermal environment of heritage buildings from the colonial period in hot arid area
Authors: Terea Chaker , Guedouh Marouane Samir , Noureddine Zemmouri
Published: November 2022

The present research aims to study the effectiveness of the envelope components of colonial dwellings in maintaining a comfortable indoor thermal environment. In hot and dry areas, extreme outdoor air temperatures compel designers to provide a better indoor thermal condition which remains a rather delicate task to achieve such as in the case of the city of Biskra. The heritage buildings were constructed in the colonial period in the Biskra region; the colonial district buildings are built with local materials such as mud bricks and stones that have a large thermal mass; these materials are the main component of the walls of the outer exterior skin. Onsite measurement campaigns were carried out to record air temperatures inside the inhabited area for 24 hours. Thereafter, the collected data were compared with the outdoor air temperatures to assess the effect of the envelope impact on the temperature variation. The important results remain in the envelope’s crucial effect to achieve thermal comfort using local materials with a high thermal mass.
"Internet +" for Targeted Poverty Alleviation by Listed Companies - A Case Study of Alibaba Group
Authors: Liu Yong , BI Chuanchen
Published: November 2022

Based on the "Internet +" concept in 2012 and the "Targeted Poverty Alleviation" strategy in 2013, many companies have found new ways to alleviate poverty through the "Internet +", which has injected new vitality into impoverished area, and also helped enterprises to promote their development in the course of poverty alleviation. This paper aims to promote the development of enterprises in the process of poverty alleviation through literature analysis and case studies. This paper intends to help more companies understand the role of "Internet +" in poverty alleviation through literature analysis and case studies, as well as how to consolidate the results of poverty alleviation and prevent the return of poverty with effective poverty alleviation methods, so as to achieve the simultaneous development of poverty alleviation and company business.
Evaluation of the treatment of purified wastewater in the city of Bouira (Algeria)
Authors: Naziha Lamri , Bachouche Nassima , Bentaleb Leila
Published: November 2022

Wastewater reuse is a popular practice in some regions of the world, affected by water shortages. After purification techniques, wastewater can be used in several areas of irrigation and industry. Only, there are international standards declared by the World Health Organization for these waters discharged from the sewage plant. In this research, we tried to evaluate these purified wastewaters by choosing the wastewater treatment plant of Bouira. We took samples of raw water and purified water to perform common physico-chemical analyses such as (pH, turbidity, temperature, BOD5, and conductivity), whose purpose is to control the quality of water before and after treatment. This control operation lasted one month (February and March) of the year 2022. The results of the physico-chemical parameters of raw wastewater and treated wastewater are analyzed and compared with the thresholds set by the wastewater treatment plant of Bouira. At the end, we have shown that the treated water does not practically meet the standards of discharge, because the values of the physico-chemical parameters and the parameters of pollution exceed the standards, which does not encourage their reuse.
The contribution of the design characteristics of public spaces in enhancing social interactionsin social housing: The case of social neighborhood of 520, M’sila, Algeria
Authors: Faid Bachir , Layeb Hafid
Published: November 2022

Thispaper studiesthe public outdoor spaces in social housing and the role ofdesign characteristics of the public spaces and their impacts on enhancing social interactions. However, since 1962, one may notice that Algeria has opted for social housing in its housing programmes to meet the growing demand; but social housing did not satisfy the residents’ needs as authorities focused on the quantity of residential neighborhoods,but they neglected designs of public spaces, which urged us to study them to see the extent to which the design characteristics of these spaces contribute to theachievement of social interactions between inhabitants.The research relies on the analytical approach by observing and analyzing the design characteristics of public spaces in social housing and their role in promoting social interactions in the neighborhood of 520 in M’sila, Algeria. A questionnaire form is addressed to the neighborhood residents to evaluate social interactions. The results of the study show dissatisfaction of the residents and the need to take into account the design characteristics during planning because of their importance in promoting social interactions
Literary aspects in the Holy Scriptures
Authors: Brînzea Nicolae
Published: November 2022

The Bible, this impressive collection of scrolls or books, establishes a well-determined hierarchical relationship, from the literary perspective of the sacred text, which raises many interesting but also difficult questions, at least from the perspective of pertaining to a certain literary genre. Hermeneutically, it highlights valuable notions related to the aesthetics of the biblical text. The Bible is a written text, hence it is literature and belongs to literature, at the same time. From a literary point of view, the Scriptures are the inevitable book that enjoys an astonishing immanence. As a sacred text, the Scriptures have produced multiple forms of literature over time. The biblical text provides a set of suggestive and significant elements that require several ways of reading, but will never fully correspond to a given historical reality. The Bible has been and continues to be an inexhaustible source of inspiration for art creators of all times. The Scriptures can be considered a reference point in the conception process of the literary text, and the starting point of biblically inspired literature is represented by lyrical works such as the Song of Songs, Psalms, etc.
Towards Sustainable Residential Buildings in Hot Arid Climates: Learning from Traditional Architecture of the Souf Region (Algeria)
Authors: Femmam Asma , Sriti Leila
Published: November 2022

In southern Algeria, the local traditional settlements have been generated as a response to material, spiritual and cultural needs of people, whilst, they have also succeeded to respond to one of the harshest climates on the planet. In this respect, the vernacular dwelling of the Souf region provides a very instructive example of what is now called sustainable architecture. Furthermore, the traditional architecture of the Souf embodies ingenious cooling design strategies relevant to occupant behaviour, environment adaptation, techniques and local materials that can offer great opportunities to overcome the desert climate conditions regarding the contemporary buildings. The present research addresses the issue by performing a qualitative analysis on two case studies that were selected to represent respectively typical traditional dwellings and common contemporary residential buildings. Based on in-field collected data, the selected examples were analysed in order to assess and compare their thermal performance and climatic adaptability. The sustainable passive design features used in the traditional dwelling were specified, evaluated and then the potential to use them as design alternatives at the early architectural design stage of contemporary housing projects was explored. Finally, a set of recommendations that illustrates the convenient passives strategies is provided for application in hot arid climates.
STUDI GEOKIMIA TANAH DAN HUBUNGANNYA DENGAN MINERALISASI LOGAM DAERAH KETUNGAU HULU, KABUPATEN SINTANG, PROVINSI KALIMANTAN BARAT
Authors: Bagus Krismantoro Nicolaus , Indro Basuki Nurcahyo , Wicaksono Hartaja Hatta , Mauritz John
Published: November 2022

Lokasi daerah penelitian berada di Dusun Aboi, Kecamatan Ketungau Hulu, Kabupaten Sintang, Provinsi Kalimantan Barat dengan luas daerah 18 km2. Penelitian ini bertujuan untuk mendapatkan hasil prospeksi emas yang lebih terperinci berupa delineasi daerah prospek berdasarkan analisis geologi, geokimia, alterasi dan mineralisasi. Metoda penelitian yang dilakukan meliputi pengambilan sampel tanah dengan sistim ridge and spur dan sampel batuan serta analisa laboratorium yang terdiri dari geokimia, petrografi, XRD dan mineragrafi.

 

Geologi terdiri dari Satuan Batupasir Greywacke, Satuan Batupasir Arenite, dan Satuan Intrusi Diorit dengan struktur yang berkembang relatif berarah utara barat laut – selatan tenggara dan barat laut - tenggara. Alterasi yang berkembang berupa zona argilik dan zona propilitik. Mineralisasi ditemukan dalam urat kuarsa bertekstur dogtooth, crustiform, colloform, dan asikuler dengan arah orientasi relatif barat laut - tenggara dan utara timur laut – selatan barat daya yang ditandai oleh adanya mineral sulfida seperti, kalkopirit, pirit, sfalerit, kovelit dan native Au dengan kisaran kandungan emas 0,61 s.d 32,8 ppm. Dari sampel tanah menunjukkan anomali Au: log 1,90 ppb, Pb: sqrt 7,44 ppm, Zn: log 1,92 ppm, Cu: log 1,69 ppm, dan Mn: log 2,46 ppm. Anomali tersebut dikontrol oleh litologi, struktur, dan topografi. Dari analisis korelasi Pearson terdapat dua kelompok unsur yaitu Au dan Pb-Zn-Cu-Mn. Berdasarkan persebaran anomali dan keterdapatan mineralisasi dapat didelineasi kemungkinan empat daerah prospek yaitu prospek KU-1, KU-2, BE-1, dan BE-2.
Influence of Circular Supply Chain Practices on the Performance of Manufacturing Firms in Nairobi County, Kenya
Authors: Kinoti Wilfred , Barasa Peter
Published: November 2022

Purpose: Previous studies conducted in Kenya and elsewhere in the world have investigated how circular economies affect various aspects of the firm’s performance such as supply chain performance, distribution, customer service among others. The goal of this study was to investigate the influence of Circular Supply Chain Practices (CSCP) on the performance of the Manufacturing Firms in Nairobi County, Kenya.

Methodology: The study adopted a descriptive Research design. The target population of this research was the eight hundred employees working in the160 manufacturing firms in Nairobi County, Kenya.  It employed a stratified sampling method whereby a sample of 100 respondents were selected, and used questionnaires to collect data. It adopted descriptive and inferential statistics to evaluate the variables numerically whereby Statistical Package for Social Students (SPSS) was used in the data analysis. In determining the relationship between Circular Supply Chain Practices and the performance of manufacturing firms in Nairobi County, Kenya, the regression model was used. The data and results of the study were presented in tables.

Findings: Findings showed that circular supply chain practices have positive and significant influence on performance of manufacturing firms in Nairobi County. The regression analysis reveals that 89.2% Variations in the performance of manufacturing firms in Nairobi County are as a result of circular supply chain practices with  (R2=0.892)

Unique Contribution to Theory, Practice and Policy: The study recommends that manufacturing firms should put in place mechanism to improve reverse logistics, green policy regulation, sustainable supply chain collaboration and product design practices. Further, the government should formulate adequate policies that would provide a good framework to make use of circular supply chain practices.
CONHECIMENTOS SOBRE HEMOVIGILÂNCIA APLICADA AO PACIENTE AMBULATORIAL: PROTOCOLO DE REVISÃO DE ESCOPO
Authors: Rodrigues Pinheiro Alaíde Maria , Garcia Filho Carlos , Sampaio Melo Etelvina
Published: November 2022

Objetivo deste trabalho é explorar na literatura, conhecimentos sobre a existência de produtos que visem à assistência ao paciente transfundido em regime ambulatorial, focando na hemovigilância, prevenção e identificação de reações adversas. Utilizando a metodologia de revisão conforme protocolo Scoping review do método JBI. Objetivando ampliar a análise de produções acerca do tema, deste modo, serão selecionados artigos bibliográficos publicados ou não, e todo conhecimento que se possa obter, sob os seguintes critérios de inclusão: narrativas sobre produção de conhecimento e a existência de tecnologias que abranja o olhar sobre a cultura de segurança do paciente que é transfundido, com enfoque no paciente atendido nos ambulatórios e que depois voltarão para os domicílios. Para isso, será realizada um esquema de busca detalhada nas bases de dados: Lilacs, Medline, Embase e Scopus. Serão necessários dois revisores para a busca, triando os títulos e resumos, selecionando conhecimentos do material elegido correspondente. Identificação e análise dos dados selecionados será feita considerando todo material escolhido como pertinente, incluindo-os na revisão e classificando em categorias e temas relevantes.