bluuebunny/crossref_metadata_2025 huggingface dataset:
Tau-PET abnormality change along with Alzheimer’s disease: a topological perspective
Authors: Ding Jie , Shen Chushu , Wang Zhenguo , Yang Yongfeng , Fakhri Georges El , Lu Jie , Liang Dong , Zheng Hairong , Zhou Yun , Sun Tao
Published: April 2023

Background: Tau PET imaging is an important biomarker for studying the progression of Alzheimer’s disease. The most commonly utilized quantification index in tau-PET is the standardized uptake value ratio (SUVR). Topological information derived from different brain regions has also been linked to tau pathology. However, previous studies on PET-based brain functional connectivity were mostly conducted at the group level.
Methods: We propose to explore the change of tau deposition from a topological perspective across different neurocognitive levels of dementia both at the individual and group levels. We have developed a method for building subject-level tau networks to investigate the correlations between brain regions. We included 18F-flortaucipir scans of participants diagnosed with cognitive normal (CN), early mild cognitive impairment (EMCI), late mild cognitive impairment (LMCI), and Alzheimer’s disease from the ADNI database. Each scan was used to build a covariance network using SUVR at regions of interest (ROIs). Topological segregation and integration information was extracted and linked to disease progression. We then extracted seven functional clusters from each subject's covariance network and analyzed the connectivity strength for each: medial temporal lobe (MTL), cognitive control, executive control, default mode (DMN), visual (VIS), somatomotor, and language. Clusters with significant change over disease progression were identified. Two converted individuals with insignificant SUVR change were then investigated from a topological perspective.
Results: Overall, topological data analysis outperformed conventional composite SUVR from signature brain regions. Connectivity strength with functional clusters can provide more accurate staging than SUVR (P<0.01), and the longitudinal change is associated better with future disease development at the subject level. MTL, DMN and VIS were identified as hubs vulnerable to early disease conversion before mild cognitive impairment. The main findings from ADNI were replicated in an independent cohort HABS.
Conclusions: The proposed method can potentially monitor Alzheimer’s disease progression at the subject level, in contrast to group-based approaches, which has great potential in monitoring disease progression and response to treatment.
AIM2 is a novel biomarker for predicting prognosis and immunotherapy response of clear cell renal cell carcinoma
Authors: Zhang Zhiyong , Zheng Zaosong , Zeng Xiangbo , Yao Zhihao , Zhu Yuanchao , Yan Guang , Zhou Jiawei , Bahaerguli Miuhuitijiang , Jie Jirong , Xie Kunfeng , Sun Jinwei , Wang Tong , Liang Jing , Liu Lei , Pang Shiyu , Tan Wanlong
Published: April 2023

Background
As an indispensable component of the inflammasome, absent in melanoma 2 (AIM2) plays an essential role in the initiation of the innate immune response, while its effects on clear cell renal cell carcinoma (ccRCC) still remain unclear. In this research, we aimed to evaluate the predictive value of AIM2 on prognosis and immunotherapy effects in patients suffering from ccRCC.
Methods
In this study, genomic and phenotypic data obtained from public databases and ccRCC patient samples from NanFang hospital were collected for exploring the correlation between AIM2 and ccRCC progression. Then we also investigated the association between AIM2 and tumor immune microenvironment of ccRCC patients. Finally, the efficacy of AIM2 was tested to predict the response to immunotherapy of ccRCC patients.
Results
Our study verified that AIM2 was significantly overexpressed in ccRCC tissues compared to adjacent normal tissues with the potential contributing factors including low methylation level and high copy number amplification level of AIM2. AIM2 was an independent prognostic marker of ccRCC patients and significantly associated with higher malignancy. Further analysis suggested that AIM2 was implicated in tumor immune microenvironment (TIME), showing a closely positive association with most inhibitory immune checkpoints. Thus, we further elucidated that ccRCC patients with higher AIM2 mRNA expression levels had more sensitive immunotherapy responses.
Conclusions
This research determined the predictive value of AIM2 in predicting the prognostic and immunotherapy effects of ccRCC patients and revealed its potential to efficiently pick out certain patients that may benefit from cancer immunotherapy.
Intercomparison between METAR- and SYNOP-based fog climatologies
Authors: Yabra Melina Sol , de Elía Ramón , Vidal Luciano , Nicolini Matilde
Published: April 2023

Weather observations and forecasts play a crucial role in the safety and economics of aviation, particularly in the presence of hazards such as fog. Climatological studies of this phenomenon are hence standard information for the aviation industry. Some aeronautical meteorological stations located at airports are also combined with synoptic stations and have to provide local and current weather conditions in two different types of reports: SYNOP for synoptic purposes and METAR for aeronautical purposes. When climatological studies are to be carried out, the question arises of which type of report is more appropriate for the task. In this work, a comparison is made between these two types of hourly meteorological observation reports, with the aim of identifying the conditions under which differences can have a significant impact on the final results. For this purpose, SYNOP and METAR reports for the period 2000-2019 from 13 Argentine airports were selected from diverse databases. A perfect agreement between the two reports is not found, but a varying degree of similarity depends on the variable. A key difference is found in “present weather” mainly due to different reporting rules. In this context, six different selection criteria using visibility, dew point depression, and present weather are used to evaluate the impact of the differences found in the fog climatology. In conclusion, SYNOP data could be used instead of METAR in statistical studies if the need arises, but with the caveat that fog frequency of occurrence should not be interpreted too strictly.
Pychastic: Precise Brownian dynamics using Taylor-Itō integrators in Python
Authors: Waszkiewicz Radost , Bartczak Maciej , Kolasa Kamil , Lisicki Maciej
Published: April 2023

In the last decade, Python-powered physics simulations ecosystem has been growing steadily, allowing greater interoperability, and becoming an important tool in numerical exploration of physical phenomena, particularly in soft matter systems. Driven by the need for fast and precise numerical integration in colloidal dynamics, here we formulate the problem of Brownian Dynamics (BD) in a mathematically consistent formalism of the Itō calculus, and develop a Python package to assist numerical computations. We show that, thanks to the automatic differentiation packages, the classical truncated Taylor-Itō integrators can be implemented without the burden of computing the derivatives of the coefficient functions beforehand. Furthermore, we show how to circumvent the difficulties of BD simulations such as calculations of the divergence of the mobility tensor in the diffusion equation and discontinuous trajectories encountered when working with dynamics on S^2S2 and SO(3)SO(3). The resulting Python package, Pychastic, is capable of performing BD simulations including hydrodynamic interactions at speeds comparable to dedicated implementations in lower-level programming languages, but with a much simpler end-user interface.
Prática docente em arquitetura e urbanismo
Authors: Kalinoski Rafael , Dall’Agnol Fiorentin Chaelin , Moro Martins Fabiana , De Andrade Pereira Bernardinis Márcia
Published: April 2023

Professores do ensino superior com amplo conhecimento técnico em suas áreas de atuação não foram necessariamente munidos de métodos pedagógicos adequados para atuar na docência. Direcionando a questão para a área de Arquitetura e Urbanismo, por exemplo, a formação de bacharel desses profissionais não inclui nenhuma preparação para a atuação em sala de aula. Pensando nisso, a disciplina de Prática Docente do Programa de Pós-Graduação em Planejamento Urbano da Universidade Federal do Paraná prepara seus mestrandos e lhes direciona a aplicar métodos pedagógicos durante o estágio docente. Neste artigo, explorar-se-á a experiência de nove mestrandos dos anos de 2018 e de 2019 que lecionaram para de 248 alunos de graduação em seus estágios. Dois métodos foram utilizados. Primeiro o Index of Learning Styles, aplicado para identificar o perfil de aprendizagem dos alunos. Com o seu resultado, posteriormente, os mestrandos puderam preparar sua aula de estágio aplicando os resultados obtidos à segunda metodologia, o Ciclo de Kolb. O objetivo desses métodos é colocar o aluno no centro do planejamento acadêmico a partir de aulas pensadas para atender os diferentes perfis de aprendizagem da turma e estimular sua participação de forma ativa nesse processo. Os resultados sugerem que a introdução à pedagogia contribui para a formação de professores capacitados para atuar em cursos de Arquitetura e Urbanismo, direcionando suas aulas para perfis de aprendizagem específicos, de natureza criativa, comuns a esta profissão.
O uso das tecnologias digitais no ensino remoto da Matemática e aprendizagem da função afim segundo Raymond Duval
Authors: Gomes de Oliveira Elizabete , Finck Brandt Célia
Published: April 2023

Este artigo apresenta uma revisão sistemática da literatura, com o objetivo de identificar, no âmbito das produções acadêmicas expressas em teses e dissertações, estudos que abordam o uso das tecnologias digitais no ensino remoto da matemática, considerando o ensino-aprendizagem da função afim à luz da Teoria dos Registros de Representação Semiótica de Raymond Duval. O estudo consiste em uma pesquisa de abordagem qualitativa, que utiliza como procedimento uma pesquisa bibliográfica. O levantamento dos dados abrangeu a Biblioteca Digital de Teses e Dissertações (BDTD) e o Catálogo de Teses e Dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Dentre os trabalhos encontrados, onze atenderam aos critérios de inclusão e exclusão, integrando o corpus da pesquisa. Após análise, os textos foram agrupados em três categorias: I - Proposta de implementação do Ensino Remoto da matemática; II - Recursos tecnológicos usados nas aulas remotas de matemática; e III - Teoria dos Registros de Representação Semiótica/Ensino-aprendizagem da função afim. Os resultados evidenciam que, durante a pandemia, os recursos tecnológicos possibilitaram o ensino-aprendizagem da matemática na Educação Básica. As análises apontam também a relevância de trabalhar as conversões entre os registros de representação gráfica e algébrica para a aprendizagem da função afim, assim como as contribuições da utilização da Teoria dos Registros de Representações Semiótica, aliadas às tecnologias para o processo de ensino-aprendizagem de funções e da função afim.
Formação continuada de professores de Ciências em caráter investigativo, interdisciplinar e com mediação por tecnologias digitais
Authors: Ferreira Marcello , Silva Filho Olavo Leopoldino da , Portugal Khalil Oliveira , Bottechia Juliana Alves de Araújo , Lima Marcilene Barros , Costa Marcos Rogério Martins , Ferreira Deise Mazzarella Goulart , Oliver Núbia Almeida Duarte
Published: April 2023

A efetividade e a qualidade educacional no Brasil têm evidenciado a necessidade de intervenções profundas no modelo adotado e em suas formas de ensino, sobretudo nas Ciências da Natureza e Matemática (CNM). Nesse sentido, a Universidade de Brasília (UnB) disponibilizou-se a colaborar com a reflexão, a crítica e a transformação desse cenário, planejando e ofertando o curso de especialização lato sensu no ensino de Ciências: o Ciência é Dez! ou C10. Essa iniciativa deu-se no Programa Ciência na Escola, com o apoio do MEC, do MCTIC, do CNPq e da Capes, centrando-se num modelo pedagógico desenvolvido nacionalmente para a oferta colaborativa em uma de instituições públicas de ensino superior (IPES). O curso é fundamentado teórica e metodologicamente em práticas investigativas, em caráter interdisciplinar e com mediação de tecnologias digitais, atendo-se aos saberes da área de CNM e ao contexto e aos desafios da Educação Básica (EB) brasileira. Em 2020, foi iniciada a oferta para três polos Brasília/DF, Planaltina/DF e Goiânia/GO – com 124 estudantes/ professores-cursistas. O planejamento pedagógico previa ações investigativas associadas à transposição didática presencial; entretanto, com a ocorrência da Pandemia de Covid-19, foi adaptado na flexibilização do perfil do ingressante e na aplicação das Atividades Investigativas (AIs) de modo remoto. Este estudo reporta, na perspectiva de um relato de experiências, as interconexões entre o projeto e as expectativas do curso com a sua efetiva execução, apontando alguns dos resultados obtidos. Com isso, pretende-se fomentar a área de estudos da CNM e da formação continuada, como um todo.
Lorcaserin: Worthy of Further Insights? Results from Recent Research
Authors: Mazza Marianna , Kotzalidis Georgios D. , Marano Giuseppe , De Berardis Domenico , Martinotti Giovanni , Romagnoli Enrico , Biondi-Zoccai Giuseppe , Abbate Antonio , Sani Gabriele
Published: April 2023

Lorcaserin is a 3-benzazepine that binds 5-HT2C serotonin receptors in the hypothalamus,
where it mediates lack of hunger and/or satiety, and in the ventral tegmental area, the site of origin of
the mesolimbic and mesocortical dopaminergic projections, which mediate pleasure and reward. The
drug has been first developed for the treatment of obesity, where it has shown efficacy, and subsequently
trialed to counter substance use (mostly cocaine, cannabis, opioids, and nicotine) and craving,
but showed inconsistent effects. Since 2020, the US Food and Drug Administration obtained that the
drug was voluntarily withdrawn from the US market on the grounds that its long-term use was found
to be associated with a greater incidence of some types of cancer. Provided it can show to be free from
cancerogenic effects, ongoing research suggests that lorcaserin may have therapeutic potential for a
variety of disorders and conditions beyond obesity. Since 5-HT2C receptors are involved in many diversified
physiological functions (mood, feeding, reproductive behavior, neuronal processes related to
impulsiveness, and modulating reward-related mechanisms) this drug has the potential to treat different
central nervous system conditions, such as depression and schizophrenia.
Experimental Investigation on Mechanical Properties of AA2195-based MMCs for Space Applications
Authors: M Srinivasa Rao , Balaram Padal Dr. K. T.
Published: April 2023

Background::

The modern Aluminium-Copper-Lithium (Al-Cu-li) based composites have a great demand in aerospace applications due to their lightweight, high strength, high stiffness, and superior mechanical properties.

Objective::

The present study explored the effect of reinforcements like graphite and boron carbide on the mechanical behaviour and microstructure of AA2195 composite

Methods::

The Medium Frequency Induction Furnace (MFIF) was used to fabricate the composites with two factors each at four levels ordered in Taguchi L16 orthogonal array.

Results::

The microstructures revealed that the reinforcements were distributed uniformly throughout the composite. The elemental investigation observed by X-ray diffraction (XRD) revealed that the formed intermetallic compounds (IMCs) helped in refining the microstructure and further increasing the mechanical properties.

Conclusion::

The composite fabricated at 8% boron carbide (B4C) and 6% graphite (Gr) exhibited better ultimate tensile strength, % elongation, and hardness as 190.74 MPa, 0.58, and 87.2VHN, respectively.

conclusion:

The composite fabricated at 8

other:

.
Bioenergy production from bacteria (Methanogens)
Authors: N.Al-Asady Israa , Arafat Mohammed Mohammed , Saadi Saeed Younis , Laftaah AL-Rubaii Bahaa Abdullah
Published: April 2023

The research deals with anaerobic fermentation and creating the conditions for bacteria (Methanogens) to carry out the process of hydration, acidification and production of methane gas. The study included the design of an anaerobic reactor made of thick glass (12) mm, with dimensions (of 35 x 35 x 35) cm, with a thermal heater inside it and a temperature set at (45) ℃, and then filled with Dairy wastewater. The Treatment period of the reactor reached two months, during which water samples were taken (72hrc) for laboratory tests (pH, COD). The laboratory tests began on 1/1/2021 and ended on 1/3/2021. COD removal of 87.12% was achieved with a neutral pH at the beginning of the second month of treatment. Biogas was obtained in this anaerobic reactor by fermentation and in the presence of bacteria (Methanogens), and its amount during the treatment period was 1.6 m3.

Keywords: Bioenergy, Dairy waste Water, anaerobic reactor, Fermentation, bacteria (Methanogens)
Influence of sage leaf water extract on several economic characteristics of Chinese duck
Authors: Hameed Blaw Haider , Habib Kaim Hanan , Kassem Al-Gharawi Jassim
Published: April 2023

This study was conducted in a private field for duck breeding in Al-Muthanna Governorate from 12/14/2021 to 02/14/2022. One hundred twenty-one-day-old chicks were reared from Pekingese ducks, with an average weight of 42 g. Ducklings were prepared from local markets in Al-Diwaniah Governorate; chicks were raised at a semi-enclosed hall with dimensions of 25 × 10 m. Chicks were randomly distributed into four treatments; each treatment was three replicates (10 chicks/replicate) placed in 12 Pens, and the area of one pen was 1.5 × 1 m. The experiment treatments were as follows: the control treatment (T1), and other treatments, used the water extract of sage leaves at a concentration of 2.5, 5 and 7.5 ml per liter of drinking water for treatments T2, T3 and T4, respectively. The results indicate that all treatments of the sage leaf extract gave the best results for the economic parameters compared to the control treatment. The T4 treatment gave the best financial performance compared to the rest of the treatments of the aqueous extract of sage leaves.

Keywords: water extract of sage leaves, economic traits, Chinese duck
Optimization of Gelling Agent and Sunscreen Activity Test of 4-OH-chalcone Gel by In Vitro Method
Authors: Zulkarnain Abdul Karim , Jumina Jumina , Kharismawati Galih Titiasari , Larasati Fina Anjani
Published: April 2023

ABSTRACT

The 4-OH-chalcone was suspected to absorb and reduce ultraviolet radiation intensity that exposed to the skin. The 4-OH-chalcone was formulated as gel dosage form using combination of carbopol in content of 0.50-1.00% w/w; propylene glycol in content of 19-20% w/w; and CMC-Na in content of 0.50-1.00% w/w. This study’s purpose was to optimize the three gel bases, evaluate physical properties, physical stability, and activity of 4-OH-chalcone gel as sunscreen by in vitro method. Simplex Lattice Design (SLD) method was used to optimize gel base with Design Expert software version 10.0. Activity of 4-OH-chalcone gel as sunscreen was determined spectrophotometrically by determining Sun Protecting Factor (SPF) value, percent transmission of erythema (% TE), and percent transmission of pigmentation (% TP). Data were analyzed statistically with SPSS Statistic software. Optimum formula of 4-OH-chalcone gel with 0.50% w/w carbopol content, 0.50% w/w carboxymethylcellulose sodium content, and 20,0% w/w propylene glycol content has pH of 5.59, viscosity of 37.4 dPa.s, spreadability of 28.8 cm2, adhesive time of 1.28 seconds, SPF value of 28.65, %, TE value of 16.44%, %TP value of 0.24%, and relatively stable physical properties.
An overview of the role of Zingiber officinale as an antimicrobial resistance (AMR) solution and a source of antioxidants
Authors: Ni Kadek Yunita Sari  , Anak Agung Ayu Putri Permatasari  , Sri Puji Astuti Wahyuningsih  , Almando Geraldi  , Putu Angga Wiradana  , I Gede Widhiantara  , Novaria Sari Dewi Panjaitan
Published: April 2023

In this review, we describe the known mechanisms of antimicrobial resistance which was increasing in this era, due to the misuse of antimicrobial agents such as antibiotics, or genetic and phenotypic mechanisms. In this review, the concerns, especially addressed by designated researchers in their study and WHO in their observations and reports, regarding the types or strains of bacteria with antimicrobial resistances were described. In addition, the predicted mechanisms that promote the development and occurrence of antimicrobial resistances, such as bacterial biofilm formation, horizontal gene transfer, genetic mutations, free DNA which contains antimicrobial resistance genes, plasmids transfer through transformation or conjugation from bacterial cell to cell were well described. In addition, we also tried to describe the use of Z. officinale. The antimicrobial capabilities of this herbal plant are attributed to its capacity to create many secondary metabolites with rather complicated structures that have antibacterial and antioxidant characteristics. Z. officinale had been used for many kinds of diseases treatment traditionally. And along the way, the advance techniques of research in chemistry and biology fields had found out the composition and bioactive compound. In this review, the common online databases such as PubMed, Semantic Scholar, Crossref, Medline, Scopus, and Web of Science (WoS) were utilized to conduct literature searches. According to recent progress of antimicrobial cases observed, the efforts to strengthen the surveillance, general health systems, tightened the antimicrobial medicine distribution rules, and education for public are indeed needed.
Penerapan Relaksasi Benson Kombinasi Unsur Keyakinan untuk Menurunkan Kecemasan pada Pasien CKD yang Menjalani Hemodialisa: Studi Kasus
Authors: Suci Rovi Apriani Eka , Hidayati Laili Nur
Published: April 2023

Background: Benson relaxation is one of non-pharmacological therapies that helps patients deal with their anxiety, thus becomes a viable option. By reducing the body’s need for oxygen and allowing the muscles to relax, the Benson Relaxation Technique which is combined with belief elements, may induce comfort and peace feelings.Objective: To evaluate the effectiveness of the Benson relaxation therapy intervention with the combination of belief elements to reduce anxiety in a CKD patient who was receiving hemodialysis. Case report: A 70-year-old man was diagnosed with chronic kidney disease (CKD) stage V. After the first hemodialysis, this patient had complained about his feeling of limp, nausea, and queasy body, fear and anxiety about his condition, and restless sleeping. Patient was given Benson relaxation technique with the combination of elements of belief for 3 days as his main intervention.Outcome: Following the use of the Benson relaxation treatment and a combination of belief elements in the form of zikir (praising to God) and istigfar (apologizing toward God) for twice a day for three days, the result had shown a decrease in HARS score from 23 (moderate anxiety) to 15 (mild anxiety).Conclusion: Patients with CKD can effectively reduce anxiety with non-pharmacological Benson relaxation therapy using a combination of beliefs elements.ABSTRAKLatar belakang: Penanganan kecemasan dapat menggunakan terapi non-farmakologi, salah satunya dengan relaksasi Benson. Teknik Relaksasi Benson dapat menghambat aktivitas saraf simpatis sehingga mengurangi penggunaan oksigen oleh tubuh dan menyebabkan otot-otot menjadi rileks serta menimbulkan perasaan tenang dan kenyamanan.Tujuan: Mengetahui efektivitas intervensi terapi relaksasi Benson dengan penambahan unsur keyakinan untuk menurunkan kecemasan pada pasien CKD yang sedang menjalani hemodialisis.Laporan kasus: Seorang laki-laki berusia 70 tahun dengan diagnosa chronic kidney disease (CKD) stadium V. Kondisi pasien setelah melakukan hemodialisis pertama mengeluhkan lemas, mual, muntah, takut dan cemas dengan kondisinya, serta mengeluh tidak bisa beristirahat dengan tenang. Pasien diberikan intervensi utama relaksasi Benson dengan penambahan unsur keyakinan selama 3 hari.Hasil: Setelah dilakukan pemberian intervensi terapi relaksasi Benson dengan penambahan unsur keyakinan seperti berzikir dan beristigfar selama 3 hari dengan frekuensi 2 kali sehari, didapatkan hasil penurunan skor HARS dari 23 (kecemasan sedang) menjadi 15 (kecemasan ringan).Simpulan: Terapi relaksasi Benson dengan penambahan unsur keyakinan efektif untuk menurunkan kecemasan pasien CKD.
Relationship of Demography with Other Sciences: A Sociological Appraisal
Authors: Taghi Sheykhi Mohammad
Published: April 2023

Demography as a dynamic discipline is highly related with other sciences; especially social sciences. It helps other sciences, and is benefited by other sciences too. Demography being statistics-based, widely helps economics, sociology, social development, geography and many other sciences. Sociology proves how integration of sciences help in the development of societies in general. Social change happening in various dimensions, is in need of a close relationship of demography and other social sciences. Social science which deals human behavior in the changing social environment is a part of expanding knowledge. Demography is the science that analyzes the size, structure of human community, are aspects of biological, geographical, economic, etc. Geography also being the science related to natural environment is widely related to sociology.
Contribution of Tree Legumes in the Production Dynamics of Yellow Yam (Dioscorea cayenensis Lam) in the South Cameroon Plateau
Authors: Djakou Guy Aurélien Nganso
Published: April 2023

The overexploitation of agricultural soils as a result of the increased need for food by local populations is leading to serious dysfunctions in land restoration. These dysfunctions, aggravated by climate change, require the implementation of ecological engineering strategies to rehabilitate the soil. The soils of the South Cameroonian plateau suffer significant degradation in terms of loss of fertilizing elements due to extensive agricultural practices, which limits agricultural production. This work showed how tree legumes contribute to improving the yield of yellow yam (Dioscorea cayenensis) in the South Cameroonian plateau, to ultimately support the production of agroecosystems in this environment. Within the framework of this study, an experimental set-up was designed to measure the performance of tree legumes in the field. The experimental set-up is a randomized complete block trial with three treatments and three replications on 3000 m2. The control plot without shrubs, the plot with Calliandra, and the plot with Senna. This trial was carried out in the district of Mbankomo, Mefou, and Akono Department, Central Region. After monitoring the experiment, it was found that Senna spectabilis produced more nutrients than Calliandra calothyrsus. Thus, each Senna shrub produced 1.54 kg of litter in the first year and 2.04 kg in the second year for a quantity of nitrogen of 192.76 kg/ha and 260 kg/ha respectively in the first and second year. Each Calliandra shrub produced 1.46 kg and 1.87 kg of litter for a nutrient amount of 183 kg/ha and 236.81 kg/ha of nitrogen during the two years of the experiment. The combination of tree legumes and field crops increased yam yields by a factor of 2 or 3 compared to traditional agriculture. The growth rate of the yam is accelerated as well as its vegetative cycle, which is reduced from 7.5 months to 6 months as a result of the increase in soil organic matter through the shrub legume litter. Agroforestry practices could have a positive impact on soil characteristics and microbial communities, resulting in enhanced soil fertility and long-term sustainability of agricultural production. According to the results obtained, the insertion of tree legumes in agrosystems is a more efficient and less costly way to gradually and sustainably increase nitrogen availability and soil fertility.
Severity of Tomato brown rugose fruit virus in tomato (Solanum lycopersicum L.) from a region of Coahuila, México
Authors: Vasquez-Gutierrez Ubilfrido , Frías-Treviño Gustavo Alberto , Aguirre-Úribe Luis Alberto , Flores-Olivas Alberto , Delgado-Ortiz Juan Carlos
Published: April 2023

The purpose of this research was to describe the Tomato brown rugose fruit virus, from three isolates collected in the field and also to use a diagrammatic scale of severity for its evaluation. The isolation was carried out with the collection of 200 ha-1 leaflets, according to a statistical method, from commercial greenhouses. Agdia® immunological strips were used to confirm the symptoms and the virus was identified by RT-PCR. A completely randomized experimental design was established in tomato plants var. Río Grande®, with three treatments or isolates and five repetitions: Blindom F1® tissue, Quiroga® Enza zaiden tissue and Quiroga® Enza zaiden fruit; Controls with phosphate buffer and buffer+celite were used as negative control. The trial began with the inoculation of 45-day-old tomato plants, where only the primary leaves were inoculated. Fertilization was carried out twice a week using macro and microelements from commercial companies. To quantify the percentage of damage to foliage and fruit, a diagrammatic scale of severity was used. The three isolates evaluated differed in the symptoms produced by ToBRFV, where; The Fruto Quiroga® Enza zaiden isolate stood out, with a higher incidence, severity and shorter incubation period compared to the two isolates evaluated.
We Have Great Stuff: Colouring Book Volume 2
Authors: Lamb Cromar Stewart , Christiansen Marta , Koppe Catherine , Aim Jackie , McShane Tracey , Ross Kirsty , Mellon Lily
Published: April 2023

Welcome to the World of Edinburgh and Colouring. This edition of the ‘We have great stuff’ colouring book is centred around the theme of a Treasure Map, in that it explores treasures found around the University of Edinburgh. It combines three things I love: first, the enchanting, beautiful city of Edinburgh, second, walking and exploring the beauty surrounding us, and third, creative pursuits, i.e. colouring. All three have been present in making this book; in finding, photographing and creating the drawings you will hopefully enjoy colouring and exploring. To walk and explore and being creative to me offer mindful breaks in a busy life, where thoughts and worries are put on hold for a minute, creating a space where I just am. Sometimes taking these breaks and doing something with my hands or my body will lead to solutions for, new ideas or realisations about what occupies my mind. The aim of this book is to encourage taking mindful breaks from the busy life of a student either in the form of colouring or walking and perhaps experience some of the peace these activities give me. We have therefore included maps at the back that show the locations of the inspiration sources, hence the name Treasure Map. Images 1-12 and 15-18 are of architectural details found around the University of Edinburgh and are meant to encourage you to explore and appreciate the beauty and possibilities of the University and the city surrounding it. Images 13-14 and 19-25 are based on photos of items found at the Centre for Research Collections housed in the University of Edinburgh’s Main Library, and home to books, art, archives, manuscripts and musical instruments. I hope you enjoy colouring and exploring.
Shame, Stigma and Colorectal Health for Bottoms
Authors: Vytniorgu Richard , Garcia-Iglesias Jaime , Merchant Azeem
Published: April 2023

This working paper explores the intersections of shame and stigma among GBMSM (gay, bisexual, and men who have sex with men) bottoms seeking colorectal healthcare. Situating these experiences in the context of complex gender performances and anxieties, the paper discusses key factors shaping bottoms’ experience of shame and stigma when seeking care for colorectal conditions. The paper highlights the perspectives of community stakeholders interested in identifying and tackling barriers to colorectal healthcare. It also identifies strategic areas for further research and collaboration, including pursuing arts-based approaches to educating healthcare providers in GBMSM sexual wellbeing.
Price Prediction for Second Hand Cars Using Machine Learning
Authors: Singh Meghsha , Reddy Thaduru Sathwik , Sameera Simma Krishna , Srinivas Sai , Reddy Sathi Surya Srijan
Published: April 2023

Abstract: The purpose of this endeavour is to create a model which can forecast the cost of a used car depending on a variety of factors, including the vehicle's model used, year of production, fuel type, price, and kilometres driven. This method may help sellers, buyers, and automobile manufacturers in the used car market. Taking into account the data provided by the users, it may then provide a relatively accurate price estimate. In the model-building process, machine learning and data science are applied. The information came from classified advertising for used cars. The researchers employed a number of regression methodologies to achieve maximum accuracy, Regression algorithms are utilized because they generate an output that is a continuous random variable instead of a categorised value. Before beginning the model-building process, this project displayed the data in order to better understand the dataset. The dataset was partitioned and altered to match the regression to ensure its performance. To assess the effectiveness of each regression, R-square method was used as more than just a result, it will be possible to figure out a car's actual price instead of merely its range in pricing. Also, a user interface that accepts input from every user and displays the pricing of a specific vehicle also on user's inputs has been developed..
Isolation and Screening of Lignin Degrading Fungi from Wood
Authors: Dudhagara Dhushyant , Payal Karetha
Published: April 2023

Abstract: Wood and lignocellulosic biomass is a low cost and abundant resource that can be used in the large scale production of fuels and chemicals. Lignocellulose can be converted into many products replacing products produced from fossil, such as bioenergy, biochemicals and biomaterial products through several treatment. In the bioethanol production, the lignin content in lignocellulose causes the conversion of cellulose to ethanol is less optimal. This research aimed to screen a number of fungal isolated from tropical forests to obtain the lignin-degrading fungi which are potentially used in lignocellulose biotreatment. The presences of covalent lignin carbohydrate linkage between sugar hydroxyl of hemicelluloses and phenylpropane subunits in lignin gives lignocellulose protection against degradation. Biofuel plays an essential role in replacing petroleum based fuels in current worldwide energy situation. The aim of the project is to identify new stain of fungi with high potential in degradation of lignin. The fungi is isolated from rotting wood piece for the study . Pereformed different methods to isolate the efficient fungi to degrade the lignin.
Indoor Navigation System
Authors: Sheikh Mo Aifaz , Dhamgaye Satyendra , Gakhare Rahul , Talewar Ayushi , Sawarkar Samiksha , Dharaskar Prof. Bhagyashree
Published: April 2023

Abstract: At some point in their life, everyone has probably gotten lost in an auditorium, had trouble finding an exit at an airport, or maybe they got there late because they didn't find suitable lecture hall in a university. But this way of getting lost in complexes and large halls could soon be a thing of the past. Today, indoor navigation apps for mobile devices are common and people need to find their destination inside tall buildings. Most indoor navigation apps use different technologies such as Wi-Fi fingerprints and Bluetooth beacons. These applications use pre-computed paths and fixed background maps to guide users to their destinations. Users of these systems need to understand how specific interior cards and card reading signals work in general. Additionally, these systems require complex and precise calculations to determine a route before navigating begins, which can be affected by spotty Wi-Fi signals. Discover Indoor Maps, the new generation of indoor navigation. In this article, we offer an indoor map that expands to 3D capabilities using augmented reality, with an increasing focus on commerce and general orientation. Indoor navigation systems integrating augmented reality allow users to locate locations in buildings and gain more knowledge about their surroundings. Although different efforts with different technologies, infrastructures and capabilities have been introduced, the procedures used to specify these systems have not yet been standardized. Additionally, while systems generally manage location contextual information in a proprietary format, a platform-independent model is desirable, which would encourage its access, updating, and management. This article proposes an approach for the development of an indoor navigation system based on the integration of augmented reality and semantic web technologies to present navigation instructions and contextual information about the environment. It consists of four modules: Defining Spatial Models, Data Management (Ontology Supported), Location and Navigation, and Content Visualization.
POLÍTICAS PÚBLICAS PARA O DESENVOLVIMENTO RURAL: DESAFIOS PARA A TERRITORIALIDADE
Authors: Oliveira de Almeida Ana Cristina , Ivo de Melo Machado Maria Rita , Lima da Silva Andrade Horasa Maria , Pires de Andrade Luciano
Published: April 2023

Com o processo de redemocratização no Brasil, no âmbito do desenvolvimento rural, políticas públicas foram propostas, conquistadas e executadas. Com este artigo, pretende-se identificar as características das políticas, a influência do contexto histórico e atual nas suas formulações, e como essas políticas são executadas na perspectiva da convivência com o semiárido. Através do método de revisão de literatura integrativa buscou-se responder à pergunta “Quais e como determinadas políticas públicas influenciaram o desenvolvimento rural no semiárido brasileiro?”. Os dados foram buscados de forma exploratória, e a seleção dos estudos foi feita a partir do resumo, palavras-chave e título, e aqueles selecionados foram analisados com base na pergunta geradora desta pesquisa. Como resultado, destaca-se as políticas públicas de compra, aquisição e distribuição de alimentos e sementes como PAA, PNAE e PAA Sementes, as políticas de captação, manejo e gestão da água como o P1MC e P1+2, de financiamento como o Pronaf, e políticas de educação contextualizada e assessoria técnica (ATER). Por fim, observa-se que a transformação socioeconômica das famílias agricultoras beneficiadas foi evidenciada nos trabalhos revisados, da mesma forma em que foi evidenciada a necessidade dessas políticas públicas continuarem sendo executadas para continuar o desenvolvimento rural, alcançando mais territórios e famílias.
Influencia de los intervalos de corte en la calidad del heno de Panicum maximum cv. BRS Tamani en el Cerrado brasileño
Authors: Gomes Eva Nara Oliveira , Dias Alexandre Menezes , Junges Luciana , Vinhas Ítavo Luís Carlos , Difante Gelson Dos Santos , Batistoti Juliana Oliveira
Published: April 2023

The grass Panicum maximum cv. BRS Tamani is a hybrid high-quality, small-sized forage plant with intense tillering activity. This study was carried out to examine the potential of the grass Panicum maximum cv. BRS Tamani at different regrowth ages (49, 63, 77, and 91 d) for hay production, in the rainy period. The experiment was conducted at the Farm School of the Federal University of Mato Grosso do Sul-Brazil, between October 2015 and April 2016. The treatments corresponded to four regrowth ages, with four replicates, distributed into 9 m2 plots. Regrowth ages influenced the morphogenetic characteristics of the grass, except for leaf senescence and final leaf length. Green (9.6–17.6 t ha-1) and dry-matter (2.6–5.9 t ha-1) yields, hay yield (3.4-6.9 t ha-1), and proportions of stem (91.6–455.9 g kg-1) and senescent material (34.8–98.4 g kg-1) increased with the regrowth ages, while the proportion of leaves (837.7-402.1 g kg-1) and the leaf: stem ratio (15.9–0.9) decreased (P<0.05). The dry matter (881.7–852.8 g kg-1) and protein contents (81.2–47.6 g kg-1) of the hay decreased with the higher regrowth ages; however, the neutral detergent fibre (746.5–759.2 g kg-1) acid detergent fibre (519.8–567.7 g kg-1) and lignin (74.3–86.4 g kg-1) contents rose as the regrowth ages did. Nutrient digestibility decreased with the regrowth ages (P<0.05). Panicum maximum cv. BRS Tamani has the potential to produce of hay ha-1, better nutritive value and a high proportion of leaves in the regrowth interval of 49 to 63 d.
Evaluación de la seroconversión de cerdas con el uso de un inóculo a diferentes dosis y vehículos contra la diarrea epidémica porcina
Authors: García Cano Rubí Nancy Paulina , Martínez-Castañeda Francisco Ernesto , Hernández Trujillo Elein , Sarmiento Silva Rosa Elena , Beltrán Figueroa Rolando , García-Hernández Montserrat Elemi , Trujillo-Ortega María Elena
Published: April 2023

La diarrea epidémica porcina (PED) es una enfermedad entérica altamente contagiosa en los cerdos, que ha provocado grandes pérdidas económicas a la industria porcina a nivel mundial. Las medidas conocidas para el control de la PED, antes del desarrollo y lanzamiento de las vacunas en el 2017 en México, fue el “feedback” o “licuado”. Aunque fue una medida muy utilizada durante el brote de PED en 2013, entre los diversos autores que lo recomiendan no hay una homogeneidad en su uso. Actualmente, diversos estudios han experimentado otro tipo de profilaxis, como la inmunización oral con el virus de la PED obtenido a partir del aislamiento en cultivo celular, lo que permite cuantificar el virus infectivo, así como asegurar que solo se está utilizando como inóculo al virus y no otros agentes. El objetivo del presente estudio fue comparar el tiempo de seroconversión, en cerdas inoculadas con virus cuantificado, con cuatro diferentes vehículos (leche, trigo, directo y agua) y diferentes dosis del vehículo (1 ml, 2 ml y 3 ml), en diferentes momentos de gestación y número de partos. El estudio se realizó en el CEIEPP, granja de ciclo completo con 170 hembras. El presente estudio demostró que los vehículos con mejores resultados fueron el inóculo con agua y el inóculo directo combinado con la dosis de 1 ml, ya que la combinación de estos vehículos y dosis del inóculo generó que más del 90 % de las cerdas mostraran seroconversión a partir de la segunda semana post-inoculación.
Instrumentos para avaliação da Atenção Primária à Saúde: revisão integrativa
Authors: Souza Oliveira Kaline Nayanne de , Silva Santos Yanca Carolina da , Alves Pinto Antonio Germane , Coêlho Correia Sampaio Yana Paula
Published: April 2023

A avaliação da Atenção Primária à Saúde (APS) busca evidências científicas sobre sua real efetividade. Traz consequências importantes, como a definição de políticas públicas. O objetivo foi analisar a produção científica resultante da aplicação de instrumentos de avaliação à área da Atenção Primária à Saúde. Esta revisão integrativa utiliza o protocolo PRISMA nas bases de dados LILACS, Scopus, PubMed, BIREME e Scielo. Um total de 2.785 manuscritos foram identificados, critérios de elegibilidade selecionados 46 e, no final, incluídos 20 manuscritos na revisão. O PCATool-Brasil foi o instrumento mais utilizado, seguido pelo Sistema de Monitoramento e Avaliação da Atenção Básica – QualiAB, entrevistas não diretivas, coleta e análise de dados secundários. Dada a complexidade da APS, recomenda-se que seus processos de avaliação considerem o contexto de participação de instituições de ensino, pesquisa, profissionais, gestores e usuários.
Review of Marco Bagli. 2021. Tastes We Live By: The Linguistic Conceptualisation of Taste in English. Berlin: De Gruyter Mouton. ISBN-13: 978-3110626773 (hardback)
Authors: Feng Yuqing , Lin Zhengjun
Published: April 2023

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The meaning of welcome. Positive migration discourse
Authors: Ponton Douglas Mark
Published: April 2023

Human e/migration across the Mediterranean increased significantly in the first part of the 21st century. At the mercy of people smugglers, migrants who succeed in crossing the seas face uncertain futures in Europe. Such immigration is at the heart of political debate in Europe, where right-wing populist parties have made significant gains because of their opposition to it. These parties tend to view human migration as a negative phenomenon, using familiar and by now even clichéd cultural and socio-political arguments against it. This study explores some of these discursive tropes. Rather than following studies that use a critical discourse paradigm, the paper’s main aim is to identify positive discourse and practice that might represent models for future behaviour in this context. It focuses on a discussion on recent migration involving Italy and, by applying tools of pragmatic analysis, united to knowledge of the socio-political background, traces some underlying trends in migrant reception. The data analysed were gathered by interviewing an Italian mayor who has attracted hostility from right-wing media for his novel approach to migrants, whose needs are met by finding them a place in the local social context. Findings suggest that, in certain circumstances, the migratory phenomenon may benefit not just the subjects involved but also the places concerned. The study thus foregrounds the degree to which welcoming the cultural other counters social discourses that currently appear triumphant in mainstream media and electoral processes.
USE OF HIGH SULFATE FLY ASH IN PUMICE BLOCKS
Authors: DENKTAŞ Serhat , TÜRK Furkan , KESKİN Ülkü Sultan
Published: April 2023

In order to reduce cement consumption, which is one of the significant factors in man-made carbon dioxide emissions, studies are being conducted on issues such as alternative building materials. Replacing cement with fly ash is at the forefront of cement reduction studies. However, the use of fly ash with a high sulfate content in structural elements is limited by European and American standards. Here the production of pumice stones used as wall material is discussed. Pumice blocks were made by replacing the cement in pumice blocks with high sulfate fly ash. High sulfate fly ash increased the late strength of pumice blocks by about 13%. In addition, as a result of a brief economic analysis for Türkiye, it turned out that wall costs could be reduced by up to 8% thanks to the replacement of fly ash. The mechanical and physical tests performed on the blocks produced concluded that the cement could be replaced with fly ash with a high sulfate content of up to 30%.
Early-warning evaluation of land ecosystem health in the Poyang lake eco-economic zone
Authors: Wei Peng , Fu Yongqi , Yu Dun
Published: April 2023

According to the dynamic, complex, and opening characteristics of land
ecosystems, we constructed an evaluation indicator system for
early-warning of land ecosystem health (LEH) based on a perspective of
state–danger–response. Then, we analyzed the warning condition of LEH
in the Poyang lake eco-economic zone in China over the past decade using
the variable weight matter-element model. The LEH status in the study
region improved obviously from 2010 to 2020. The warning condition of
regional LEH in 2010, 2015, and 2020 was in the “warning”,
“relatively healthy”, and “healthy” stages, respectively. The
evolution of LEH was better demonstrated by the variable weight
matter-element model than by the traditional method because the former
could modify the weight of early-warning indicators and eliminate the
incompatibility between indicators. Our study provides an alternative
approach for research into ecosystem health, and the results will be
useful for improving LEH in the study region.