bluuebunny/crossref_metadata_2025 huggingface dataset:
Neonatal and Maternal Outcomes of Insulin Detemir versus Neutral Protamine
Hagedorn for Diabetes Mellitus in Pregnancy
Authors: Bugazia Seif , Boshnaf Mohamed , Elbahnasawy Mohammad , Shehata Mostafa , Alqatati Fadel , Ragab Khaled Mohamed , Elsnhory Ahmed Bostamy , Elsayed Sarah Makram , Fathy Mustafa Ali , Nourelden Anas Zakarya
Published: June 2022

Background and objectives:

Diabetes in pregnancy can lead to severe neonatal and maternal adverse events. Moreover, there is an increase in GDM prevalence. Therefore, we aimed to compare insulin detemir (IDet) with the neutral protamine Hagedorn (NPH) in diabetic pregnant women.

Methods:

We searched four electronic databases until August 2021: PubMed, Scopus, Web of Science, and Cochrane. We included randomized controlled studies that compared IDet with NPH in diabetic pregnant women. We extracted both maternal and neonatal outcomes, and used RevMan software to conduct the analysis.

Results:

A number of five studies were included. The analysis showed a significantly lower risk of hypoglycemic events during pregnancy in the IDet group than the NPH group [RR=0.6, 95% CI [0.43, 0.84], p=0.003], and a higher gestational age (GA) at delivery in the IDet group than the NPH group [MD= 0.28, 95% [0.02, 0.55], p=0.03]. On the other hand, the analysis revealed non-significant differences between IDet and NPH in terms of birth weight, congenital anomalies, neonatal hypoglycemia, preterm delivery, and others.

Conclusion:

Insulin detemir (IDet) was preferred over neutral protamine Hagedorn (NPH) in terms of showing lower rates of hypoglycemic events during pregnancy and a higher gestational age at delivery. Meanwhile, there were non-significant variations between them when it comes to neonatal outcomes, such as weight at birth, congenital anomalies, or neonatal hypoglycemia.
Introduction of Accurate Measurement of the Alveolar Bone Height in
Bone Grafting Area after Sinus Lift
Authors: Yu Yuehai , Xu Yan , Sun Jin , Xu Yao
Published: June 2022

Background:

Sinus lift via the alveolar crest approach has been proven to solve inadequate
alveolar bone height perfectly in the posterior region of the maxilla. Nevertheless, the surgical area
cannot be directly observed, imaging methods are necessary to reveal whether the surgery has
achieved the expected results. Cone-Beam Computed Tomography (CBCT) images are usually taken
before surgery and at the completion of final pre-repair osseointegration and evaluate the effect of
maxillary sinus lift by measuring the alveolar bone height in the bone graft area. However, there is no
uniform and recognized method to accurately measure the alveolar bone height in the bone grafting
area before and after maxillary sinus lift. Therefore, the authors propose a simple, accurate, and reproducible
method for the measurement of alveolar bone height in maxillary sinus lift on CBCT, which
will be an innovation.

Methods:

30 implant cases (30 patients) were included in this study. The authors create a uniformed
measurement surface in the CBCT axial interface to ensure consistency at the completion of final prerepair
osseointegration and before surgery. Then changes in alveolar bone height in the bone grafting
area before and after sinus lift were measured on CBCT coronal and arch planes. Finally, for the purpose
of verification of repeatability, three dentists from our department were randomly selected to
measure and record the above CBCT data at three different time points.

Results:

The data showed that in the CBCT measurements of the three dentists, neither the coronal
plane nor the arch plane was statistically significant. (P > 0.05).

Conclusion:

This measurement method is simple, accurate and repeatable. It can be applied to measure
alveolar bone height in the bone grafting area before and after maxillary sinus lift.
Advanced Plasmonic Nanosensors for Monitoring of Environmental Pollutants
Authors: Denizli Adil , Çimen Duygu , Bereli Nilay
Published: June 2022

Background:

Water is polluted day by day with biological and chemical toxins that can pose a serious threat to human health, animals and ecosystems. The regular identification and monitoring of biological and chemical toxins in water resources is the first step of the preventive method. The devices used in traditional detection methods such as adsorption and chromatography combined with mass spectrometry are not easy to transport for analysis and involve laborious preliminary sample preparation steps. However, the developments in nanosensors prepared with nanomaterials provide solutions to these challenges. Nanomaterials such as gold nanoparticles, graphene and quantum dots are often preferred for the surface preparation of plasmonic nanosensors for the selective, sensitive and label-free detection of very low concentrations of pollutants in water.

Methods:

There are different plasmonic nanosensors such as electrochemical, colorimetry and optical sensors prepared using different nanomaterials for the determination of environmental pollutants. These different detection nanosensors also have many advantages and disadvantages. In this review, the use of different nanomaterials in different types of plasmonic nanosensors for the determination of environmental pollutants, their modification and their effects on performance in terms of signal enhancement will also be discussed.

Results::

When the studies in the literature are examined, although many articles have been published on the detection of pollutants in water, the number of publications specific to nanomaterial-based plasmonic nanosensors for detection is quite limited. In this review, we focused on the use of different nanomaterials in the preparation of nanosensor surfaces for the detection of environmental pollutants, and the preparation, optimization, experimental analysis and application areas of different plasmonic nanosensors made in the literature for detection methods

Conclusion::

Recent developments in plasmonic nanosensors, nanomaterials such as gold nanoparticles, graphene and quantum dots provide ultra-sensitive detection at the molecular level, leading to extraordinary developments. Nanomaterials have important plasmonic properties and are preferred for the selective, sensitive and label-free detection of very low water pollutant concentrations. In studies conducted in the literature, it has been observed that environmental pollutants such as toxin, bacteria, heavy metal ions, pesticides, especially in water, are determined and analyzed. In these review, it was observed that the sensitive and selective properties of nanomaterial-based nanosensors yielded results with low detection limits. The current review includes developments and application-oriented progress of nanomaterial-based plasmonic nanosensors, especially for the detection and quantification of various pollutants and environmental pollutants in water.
New neo-Clerodane Diterpenoids Isolated from Ajuga decumbens Thunb., Planted
at Pingtan Island of Fujian Province with the Potent Anticancer Activity
Authors: Yong Jianping , Lu Canzhong , Zacchaeus Olatunde Olagoke
Published: June 2022

Aims:

The aim of this study is to find the anticancer lead compounds or drug candidates from Chinese Traditional
Plant Medicine of Ajuga decumbens Thunb.

Background:

Ajuga decumbens Thunb. has been used in clinical for a long time in China and was selected in “Chinses
Pharmacopoeia” (part I in 1977) for its wide spectrum biological activities: such as anticancer, antioxidant, antifeedant,
antibacterial, anti-inflammatory, antihyperlipidemic, anti-cholinesterase and cytotoxicity activities. However, there are
relatively fewer studies of Ajuga decumbens Thunb. that have been carried out till now. For some years, our research
group focused on the discovery of new anticancer agents, so we studied the chemical compositions of Ajuga decumbens
Thunb., planted in Pingtan island of Fujian Province, to discover new anticancer lead compounds or candidates
from this Chinese Traditional Plant Medicine.

Methods:

The dichloromethane (DCM) extract was obtained in this work, and then this extract was used for silica gel
column chromatography to obtain different polar fractions. Several similar fractions were combined according to TLC
or HPLC analysis. The combined fractions were isolated by preparative TLC or preparative HPLC to obtain the pure
compounds and HPLC was used to detect the purity. All isolated compounds were determined by NMR (1HNMR,
13CNMR, DEPT, HMBC, HSQC, 1H-1H COSY and NOESY), HRESIMS and single crystal X-ray diffraction methods.
The in vitro anticancer activity was evaluated using CCK8 method.

Result:

Seven compounds [three new compounds 1-3； and four known compounds (Ajugacumbins A, Ajugacumbin
B, Ajugamarin A2 and Ajugamarin A1)] were isolated from Ajuga decumbens Thunb. in this work, and
their structures were confirmed. The biological evaluation showed that 3 and Ajugamarin A1 exhibited potent in vitro
anticancer activity both against A549 cell lines with IC50s=71.4 μM and 76.7 μM; and against Hela cell lines with
IC50s=71.6 mM and 5.39×10-7 μM, respectively.

Conclusion:

Compounds (3 and Ajugamarin A1) can be regarded as the lead compounds for the development of anticancer
agents.
A Review on CO2 Absorption using Chemical Solvents at Low and High CO2 Partial Pressure Conditions in a Packed Column
Authors: Halim Hairul Nazirah Abdul , Rajiman Viga , Shariff Azmi Mohd
Published: June 2022

CO2 removal is important for industrial flue gas treatment, biogas enhancement, and natural gas (NG) processing applications. Chemical absorption using an amine-based solvent is a proven technology for CO2 removal from various gases. In recent years, various promising amine solvents have been investigated, either as single or blended solutions, to enhance the CO2 absorption process at low and high CO2 partial pressure conditions. Low CO2 partial pressures (1 – 47 kPa) have been utilized in numerous research works focusing on flue gas treatment and biogas enhancement applications. On the other hand, high CO2 partial pressures were instead applied in NG processing ranging between 750 and 1600 kPa. To provide more insight into the current trends, existing research on CO2 absorption in amine-based solvents is presented in this review focusing on absorption performance in a packed column at low and high CO2 partial pressures. Reports on the effect of different parameters, namely CO2 partial pressure, gas, and liquid flow rates, amine concentrations, and liquid temperature, on the removal of CO2 in the packed column are included. Based on the review, the future direction is further highlighted in this area.
Treatment with Biostimulants Extracted from Salix babylonica L. Induces
Drought Stress Tolerance in Zoysia tenuifolia
Authors: Ri Kum Chol , Ri Jin Ui , Gao Yang
Published: June 2022

Background:

Drought stress limits the growth of plants and even impairs their physiological
functions. Under water stress, Zoysia tenuifolia has limited biomass, plant height, and leaf
length, as well as decreased protective enzyme activity, while it induces the accumulation of large
amounts of osmotic regulators. If a plant is in a severely water-deprived environment, its growth is
clearly inhibited, and it may even die.

Objective:

The purpose of this study was to evaluate the effect of a biostimulant, a willow extract
isolated from the bark of S.babylonica, on the drought stress of Z. tenuifolia.

Methods:

First, the change in the content of salicylic acid was evaluated through the oxidation process
by potassium permanganate after acid hydrolysis of the willow extract. Second, through leaf
spraying with Z. tenuifolia, the improvement effect on drought stress according to a reasonable concentration
of willow extract was observed.

Results:

In this paper, it was found that oxidation of potassium permanganate after acid hydrolysis
of willow extract significantly increased the content of salicylic acid, a plant growth regulator, and
that leaf spray remarkably improved the physiological index of Z. tenuifolia under drought stress
conditions.

Conclusion:

This study provides important information on the identification and utilization of willow
resources as a safe plant protector and growth regulator, and is the first study to report on the
use of these willow extracts as a source of liquid extracts acting as biostimulants in Z. tenuifolia cultivation.
Evaluation of Online Grocery Platform Alternatives Using Fuzzy ZNumbers
Authors: Sari Irem Ucal , Sergi Duygu
Published: June 2022

Bacground:

Retail management has evolved into a new business model with the development of online shopping habits. There may be significant differences between onsite service
and online service in terms of customer expectations.

Introduction:

In this study, companies providing online grocery services in Turkey are evaluated
by examining the services they provide from the perspective of customers. Fuzzy Z numbers,
which also add the reliability of linguistic assessments to the analysis, are used in order to better
describe the uncertainty.

Methods:

Fuzzy Z-analytic hierarchy method (FZ-AHP) is used to weight the decision criteria, and
fuzzy Z-Grey relational analysis (FZ-GRA) method is used to find the best online market company.

Results:

As a result of the analysis, it is revealed that the most important criteria for online grocery
shopping are minimum order amount and brand diversity. The results are also compared with ordinary fuzzy methods.

Conclusion:

The comparison of the methods used in the study shows that although the ranks of the
criteria and alternatives are the same, using fuzzy Z linguistic scale results in a wider interval for
the weights and the scores of the alternatives, which could change the ordering, especially in cases
where criterion weights or alternative scores are very close to each other.
Filme & poesia contra a corrente
Authors: Malafaia Rosana , Cardoso Ribas Maria Cristina
Published: June 2022

Este estudo espera partilhar uma experiência intermidiática (Clüver, 2011; 1982) desenvolvida no documentário Pajeú - O Rio Feiticeiro (2019), de Alexandre Alencar, em cuja correnteza deságuam vozes dos cantadores nordestinos que vivem nas suas margens e respiram, improvisam e vivem a arte como fonte, resistência e produção de presença (Gumbrech, 2010) nas cidades do sertão de Pernambuco. Nossa leitura mobiliza, também, o fluxo musical (Wolf, 2020) na constituição das glosas, trovas e na musicalização das poesias.
Ослабление диполь-дипольного взаимодействия в ансамблях микросфер кобальта с немагнитным ядром
Authors: Комогорцев С.В. , Чеканова Л.А. , Шабанова О.Г. , Шабанов А.В. , Немцев И.В. , Незнахин Д.С. , Денисова Е.А. , Фельк В.А. , Мохов А.А. , Исхаков Р.С.
Published: June 2022

Magnetic microspheres with nonmagnetic acrylic glass core were fabricated using electroless deposition. There are favorable conditions for magnetic flux closure within each particle. As a result, the dipole-dipole interaction in the powder of such microspheres is reduced drastically. This is the key difference between powders of magnetic microspheres and powders of full magnetic spherical particles witch behavior is significantly affected by the dipole-dipole interaction. The magnetic hysteresis in the cobalt microspheres with nonmagnetic core is significantly large then in the full cobalt particles produced using the same technique.
Noncompete agreements, bargaining, and wages: evidence from the National Longitudinal Survey of Youth 1997
Authors: Rothstein Donna , Starr Evan
Published: June 2022

We examine the use of noncompete agreements (NCAs) and their relationship with wage bargaining and wage outcomes using new data from the National Longitudinal Survey of Youth 1997. NCAs cover 18 percent of the workers in our sample, and adoption patterns are broadly consistent with prior research. The NCA–wage correlation is positive and highly sensitive to controls for demographics and job characteristics, suggesting selection into NCAs causes positive bias in the estimates. While it is not obvious what the baseline level of the NCA–wage differential is, some heterogeneous effects are more stable: the NCA–wage differential is lower for workers who do not bargain over wages, have less education, have lower ability, or live in a state that enforces NCAs. Notably, wage bargaining—which is only marginally more likely with NCAs in our most saturated model—does not explain the heterogeneous effects across subgroups. We discuss these findings in light of competing theories of the social value of NCAs.
Effectiveness of MCH handbook development with the addition of fps variables as an early detection for pregnancy and childbirth complications
Authors: Setiani Citra Dewi Fitri , Fatmasari Diyah , Suwondo Ari
Published: June 2022

Background: The development of an early detection guidebook for risk factors in pregnant women's complications packaged in MCH books was considered effective for health workers and mothers as guidelines for the prevention of complications. However, the use of MCH books has not been maximal. Of the 81.5% of mothers who own MCH books, only 60.5% understand it. This makes one of the causes of maternal and infant mortality is ignorance of the signs of complications. In addition, in MCH books there is only an assessment of physical disorders without judging from psychological and sociological.

Objectives: The purpose of this study was to produce an MCH handbook model with addition NEW FPS (Physiological, Psychological and Sociological) factors to maximize the understanding of pregnant women and the enforcement of high potential risk diagnoses carefully and accurately.

Methods: This was Research and Development (R&D) study using Borg and Gall models. The data in the study was obtained using interviews, NEW FPS questionnaires, pregnant women's response trial questionnaires. The population in this study consisted of 16 people and taken a sample of 16 respondents who were pregnant women in trimester 3 to 3 years by using Simple Random Sampling technique.

Results: The results showed the development of MCh handbooks with the addition of FPS variabels effectively used as one of the efforts in early detection of pregnancy and childbirth with percentage results: physiological (56.2%) psychological (62.5%) and sociological (68.7%). Based on the results, the response of pregnant women to trials in the development of MCH handbooks obtained an average percentage (87%), the addition of FPS variabels to MCH handbooks was effectively used as an effort to early detection of pregnancy and childbirth complications. The fulfillment of these three aspects can increase the achievement of the MCH program in the early screening of complications.
Conclusions: This study concludes that the addition of NEW FPS variabels in MCH handbooks is feasible and effectively used as one of the media to conduct early detection of the occurrence of pregnancy and childbirth.
Identification of the needs couples against prenatal class program in Badung Regency
Authors: Astiti Ni Komang Erny , Purnamayanti Ni Made Dwi
Published: June 2022

Background: Pregnancy causes changes in physical and psychological. Sometimes it causes a maturation crisis. The husband's support is expected to be optimal. So far, pregnancy education has focused on the mother, so the husband cannot carry out his role optimally.

Objective: This study aims to identify the information needs of couples about the materials, methods, media, repetitions, and duration of couple prenatal class in Badung Regency.

Methods: This research is a mixed-method explanatory sequential. This research was conducted in Badung Regency with 100 couples. Data analysis went through the stages of transcription, reduction, coding, categorization and finding themes. The results obtained six themes: subjects, functions, forms, awareness, quantity, and quality of health education. The next step is quantitative, the questionnaire contains the types of material needs, media, methods, duration and repetitions of health education needed by couples.The results of quantitative research were analyzed descriptive quantitatively..

Result: This study consisted of 6 themes that were used as the basis for compiling a quantitative research. This research questionnaire consists of 30 items which include material, media, method, duration and repetition of health information needs about pregnancy, childbirth, postpartum and newborn which are assessed with a Likert scale.The findings revealed that the most common pregnant topics were fetal stimulation, danger indicators, and complaints, as well as how to deal with them. Pain management strategies, the role of the husband, and early breastfeeding initiation are the essential delivery materials. Danger indicators, breastfeeding issues, and managing and caring for postpartum are the most needed during the postpartum time. Bathing and caring for the umbilical cord, growth, development, and massage are the essential newborn care items. Interactive media, hybrid approaches, duration, and repetition of material adapted to the urgency and demands of couples are all desirable learning media.

Conclusion: The needs of couples for health education in a couple of prenatal classes are very varied, including materials, media, methods, duration, and repetitions.
The Momentum trial: the efficacy of using a smartphone application to promote patient activation and support shared decision making in people with a diagnosis of schizophrenia in outpatient treatment settings: a randomized controlled assessor-blinded trial (Preprint)
Authors: Vitger Tobias , Hjorthøj Carsten , Austin Stephen F. , Petersen Lone , Tønder Esben , Nordentoft Merete , Korsbek Lisa
Published: June 2022

BACKGROUND

Shared Decision Making (SDM) is a process aimed at facilitating patient-centered care by ensuring that the patient and the provider are actively involved in treatment decisions. In mental healthcare, SDM has been advocated as a mean for the patient to (re)gain control and responsibility over his/her life and recovery process. To support the process of patient-centered care and SDM, digital tools may have advantages in terms of accessibility, structure, reminders etc.

OBJECTIVE

The present RCT investigated the effect of a digital tool to support patient activation and SDM.

METHODS

The trial was designed as a randomized, assessor-blinded, two-armed parallel-group, multi-center trial investigating the use of a digital SDM intervention for 6 months compared with treatment as usual. Participants with a diagnosis of schizophrenia, schizotypal or delusional disorder were recruited from nine outpatient treatment sites in the Capital Region of Denmark. The primary outcome was self-reported level of activation at post-intervention. The secondary outcomes included self-efficacy, hope, working-alliance, satisfaction, preparedness for treatment consultation, severity of symptoms and level of functioning. Explorative outcomes on the effect of the intervention at mid-intervention together with objective data on usage of the digital tool was collected.

RESULTS

A total of 194 participants were included. The intention-to-treat analysis revealed a statistically significant effect favoring the intervention group on patient activation (mean difference = 4.39, CI: 0.99 to 7.79, d=0.33, p=0.01); confidence in communicating with one’s provider (mean difference = 1.85, CI: 0.01 to 3.69, d=0.24, p=0.05) and; feeling prepared for decision making (mean difference = 5.12, CI: 0.16 to 10.08, d=0.27, p=0.04). We found no effect of the digital SDM tool on treatment satisfaction; hope; self-efficacy; working alliance; severity of symptoms; level of functioning; use of antipsychotic medicine; number, or length of psychiatric hospital admissions.

CONCLUSIONS

The present trial showed a significant effect of a digital SDM tool on subjective level of patient activation together with important secondary outcomes at post-intervention. The effect size was smaller than the 0.42 that we had anticipated and sampled for. The trial contributes to the evidence on how digital tools may support patient-centered care and SDM in mental healthcare.

CLINICALTRIAL

ClinicalTrials.gov NCT03554655

INTERNATIONAL REGISTERED REPORT

RR2-doi: 10.1186/s12888-019-2143-2
Identifying Hotspots of Tuberculosis in Nigeria using EWORS: Implications for Active Case Finding and Intervention (Preprint)
Authors: Ogbudebe Chidubem , Odume Bethrand , Chukwuogo Ogoamaka , Useni Sani , Dim Cyril , Okuzu Okey , Jeong Dohyo , Malolan Chenchita , Kim Dohyeong , Nwariaku Fiemu , Nkiru Nwokoye , Gande Stephanie , Nongo Debby , Eneogu Rupert , Odusote Temitayo , Oyelaran Salewa , Chijioke-Akaniro Obioma , Gidado Mustapha , Anyaike Chukwuma
Published: June 2022

BACKGROUND

Undiagnosed tuberculosis (TB) cases are the major challenge to TB control in Nigeria. Though the Early Warning Outbreak Recognition System (EWORS) is primarily used to detect infectious disease outbreaks, it can be used as a case-based geospatial tool for the real-time identification of hotspot areas with TB patients' residence in clusters. TB screening targeted at such hotspot wards should yield more TB cases when compared to non-hotspot areas.

OBJECTIVE

To demonstrate the effectiveness of EWORS TB hotspot mapping as a tool for detecting areas with increased TB case yields in high TB burden States of Nigeria.

METHODS

KNCV Nigeria deployed EWORS to the 14 high burden States of Nigeria. The system used an advanced surveillance mechanism to identify TB patients’ residences in clusters, enabling it to identify areas with elevated disease spread (hotspots) at the ward level. TB screening outreach using the WHO-four-symptom screen was conducted in 175 hotspot wards and 173 non-hotspot wards selected from the same communities. Presumptive cases identified were evaluated for TB using the GeneXpert instrument or chest x-ray. Confirmed TB cases from both areas were linked to treatment. Data from the hotspot and non-hotspot wards were analyzed retrospectively for this study.

RESULTS

A total of 1,962,042 persons (37.4% males, 62.6% females) versus 2,025,286 persons (34.6% males, 65.4% females) participated in the community TB screening outreaches in the hotspot and non-hotspot areas, respectively. Presumptive cases among all clients screened were 268,264 clients (6.7%) and confirmed TB cases were 22,618 clients (8.4%). The number needed to screen for the hotspot and non-hotspot areas was 146.22 versus 193.44 per 10,000 population, respectively.

CONCLUSIONS

Active TB case finding in EWORS-mapped hotspot areas yielded higher TB cases than the non-hotspot areas of 14 high burden States of Nigeria. After the intervention of EWORS, the precision to diagnose TB from presumptive increased from 0.077 to 0.103. The number of presumptive needed to diagnose a TB case decreased from 14.047 to 10.255 per 10,000 population.
Validity and reliability study of diabetes fatalism scale inturkish patients with type 2 diabetes Corrigendum: International Journal of Endocrinology (Ukraine) 2022;18(8):440-445. doi: 10.22141/2224-0721.18.8.2022.1223
Authors: Kavuran E. , Yildiz E.
Published: June 2022

Background. Turkey is one of the them that has the highest prevalence in Europe, with about one in every seven adults diagnosed diabetes mellitus. By 2035, Turkey will have the highest number of people with type 2 diabetes in Europe, at almost 12 million. Mortality rates have increased with the increasing prevalence of type2 diabetes, especially in the younger population, such that half of the deaths come from those under sixty. The beliefs and mental state of patients with chronic illnesses like diabetes can affect disease outcomes and the patients’ self-management. Self-care and diabetes medications are important components in improving the disease outcome, though many studies have shown that these activities can be negatively related to fatalism about the disease state. The aim of this study was to investigate the reliability and validity of the Turkish version of the Diabetes Fatalism Scale (DFS), which was developed by Egede. Materials and methods. This was a methodological study. The scales were administered to a total of 139 patients with type 2 diabetes. The content and construct validity of the scale were assessed. The construct validity was evaluated using confirmatory factor analysis (CFA), and the reliability was assessed in terms of internal consistency. Results. In terms of the population tested, 54.7% of the participants were men, 73.4% were married, 54% had another disease, 18% were high school graduates, the average age was 50.20±16.82 years, the average duration of diabetes was 19.31±14.25, and mean glycated hemoglobin (HbA1c) level was 7.06±0.65%. It was found that the Kaiser-Meyer-Olkin (KMO) measure of sampling-size adequacy was 0.770, indicating an adequate size, and the chi-square value was 1078.402. When the fifth item was excluded from the study and the analysis was repeated, the KMO coefficient was 0.802 and the chi-square value was 1020.244, p=0.000. The Cronbach’s alpha value reached 0.806, indicating a good internal consistency. The Cronbach’s alpha values of the other subscales also seemed to be at a very good level. Conclusions. Our study showed that the DFS is a valid and reliable scale for the Turkish society. DFS-T is a suitable scale for health professionals to use to assess the fatalism of diabetic patients in Turkey.
Management of a patient with cardiac arrest: a clinical case of massive pulmonary embolism in an obese young man
Authors: Netiazhenko V.Z. , Malchevska T.I. , Shkala L.V. , Puzanova O.G. , Altunina N.V.
Published: June 2022

Pulmonary artery thromboembolism is one of the few life-threatening conditions. Today, with less mobility due to their professional activities (prolonged sitting at a computer) and social behavior, the number of cases of venous thromboembolism has increased. The recommendations of the European Society of Cardiology for pulmonary embolism (2008, 2014, 2019) have become a powerful tool for diagnosing, treating and stratifying the risk of death. Prevention of recurrence of thromboembolic complications and its duration depends on the fact of provocation of pulmonary embolism. Recommendations for the development of thromboembolic complications take into account the presence of heart failure, coronary heart disease, atrial fibrillation (AF), which to some extent blurs the distinction between arterial and venous thrombosis. The fact that the incidence of pulmonary embolism increases with age is indisputable, but in contrast to atherothrombosis, venous thrombosis occurs much earlier, in the younger population. Thus, venous thrombosis is somewhat “younger” than arterial. Regarding gender differences, it is more common in men with age, and women tend to “rejuvenate”. Contraceptives play an important role in this, the risks of venous thromboembolism are pregnancy and childbirth. Although less influential in the development of venous thromboembolism and pulmonary embolism are bed rest (more than three days), immobilization in a sitting position (long flight, car trip), old age, in real clinical practice should not be neglected laparoscopic surgery and concomitant conditions— obesity, diabetes mellitus, hypertension and varicose veins. At the slightest suspicion of pulmonary embolism, it is important for the physician to consider the above factors. A clear algorithm for diagnosis and timely treatment will ensure the effectiveness of such patients and the process of their recovery. In recent years, obesity at the angle of low-intensity inflammation began to be considered involved in the processes of increased thrombosis. Although certain mechanisms of thrombosis in obesity have been elucidated, the frequent fatal thrombotic consequences of severe COVID-19 remain unclear, mainly in the category of patients with obesity, carbohydrate metabolism disorders, and diabetes. In this clinical case, the authors demonstrate the total stratification of risk factors, even at first glance insignificant effects of obesity of the first degree, but in combination with varicose veins of the lower extremities, which caused massive pulmonary embolism in young men.
Laron syndrome: clinic, diagnostics (а clinical case)
Authors: Lіashuk P.M. , Lіashuk R.P. , Stankova N.I. , Kudina M.B.
Published: June 2022

The combination of normal/high levels of somatotropic hormone with low levels of insulin-like growth factor-1 is characteristic of impaired receptor sensitivity to somatotropic hormone, a rare genetically determined syndrome described by Israeli clinician Z.Laron. In addition to the relative deficiency of somatotropic hormone, in contrast to pituitary dwarfism, other functions of the pituitary gland are not changed. Against the background of a sharp lag in growth from an early age, sometimes from the fetal period, children retain normal body proportions. The case of rare endocrinopathy— genetically determined Laron’s syndrome is described. Ethiopathogenesis, features of clinical course of disease and prospects of therapeutic approach are considered. The clinical signs of the main forms of growth retardation are presented. The diagnosis of Laron’s syndrome is made on the basis of short stature in the absence of other endocrinopathies, low levels of insulin-like growth factor-1 with a normal reference value of somatotropic hormone and no effect of treatment with somatotropic hormone. The patient needs further observation by an endocrinologist before the onset of puberty and, if necessary (in the case of the formation of inferiority complex), іn psychological correction. General recommendations on the completeness of the diet, sleep, physical activity and physical therapy are given. Prescribed multivitamins. Attempts to use insulin-like growth factor-1 genetically engineered drugs are encouraging. When making a differential diagnosis between the main forms of growth retardation and stunted growth, the family physician and endocrinologist should be prescribed hormonal blood tests and imaging methods according to the previous indicative diagnosis according to clinical data.
Fabrication of Chitosan/Fe3O4 Nanocomposite as Adsorbent for Reduction Methylene Blue Contents
Authors: Harimu La , Wahyuni Sri , Nasrudin Nasrudin , Baari Muhamad Jalil , Permana Dian
Published: June 2022

Methylene blue (MB) is a dye in wastewater from textile industries that pollutes the water environment. Reduction of its content is necessary for protecting humans and the surrounding environment. This study fabricated chitosan/Fe3O4 nanocomposite through the mixture of chitosan from crab shell waste and magnetite (Fe3O4) from local sand iron with sodium tripolyphosphate (STPP)-sulfate crosslinker as an adsorbent to reduce methylene blue content. The obtained composite was characterized by Fourier Transform Infrared (FTIR) Spectrophotometer and X-Ray Diffraction (XRD) instrument. The contents of methylene blue before and after applying adsorbent-based nanocomposite were determined using an ultraviolet-visible (UV-Vis) spectrophotometer. FTIR characterization results show that chitosan and chitosan/Fe3O4 nanocomposite had successfully synthesized based on the typical vibrational peaks. The deacetylation degree of chitosan was 69.79%. Fe3O4, and chitosan/Fe3O4 nanocomposite, were confirmed by XRD patterns. The chitosan/Fe3O4 nanocomposite adsorption capacity reached 45.37 mg/g when adsorption occurred with 20 mg adsorbent, pH 9, and contact time of 1.5 h. Hence, the chitosan/Fe3O4 nanocomposite in this study has potency and is applicable to adsorb MB effectively.
Selection of the Parameters in the Synthesis of Ethylenediamine-Folate Using the Plackett Burman Design
Authors: Purnamasari Erianti Siska , Septiana Linda , Hardianto Ari , Soedjanaatmadja Ukun Mochammad Syukur , Anggraeni Anni , Bahti Husein Hernadi
Published: June 2022

This study is concerned with synthesizing ethylenediamine-folate (EDA-Folate), which will then be used as a precursor in synthesizing Gd-PEG-DOTA-Folate, a novel targeted-contrast agent for the diagnosis of cancer, employing the Magnetic Resonance Imaging method. This study aims to determine all the parameters affecting the synthesis of EDA-Folate using the Plackett Burman design. The synthesis method included activation of folic acid using dicyclohexylcarbodiimide and N-Hydroxysuccinimide to result in NHS-Folate, followed by conjugation of ethylenediamine with NHS-Folate to produce EDA-Folate. Analysis of the reaction product confirmed that the reaction product was EDA-Folate. From the resulted data, it can also be concluded that there were four significant parameters (out of the ten parameters studied) in the synthesis of EDA-Folate (with its value presented in the bracket), i.e., time inactivation of NHS-Folate (24 h), stirring rate inactivation of NHS-Folate (300 rpm), the mole of EDA (12 moles), and time of EDA-Folate (12 h). Moreover, the value or desirability of the experimental design was found to be 0.875 (which is < 1.0), meaning that the design will produce optimal conditions and thus the optimal yield of the reaction.
A Potential Approach for Converting Rubber Waste into a Low-Cost Polymeric Adsorbent for Removing Methylene Blue from Aqueous Solutions
Authors: Aliyu Muhammad , Abdullah Abdul Halim , Bin Mohamed Tahir Mohamed Ibrahim
Published: June 2022

Exploiting waste materials to make cost-effective adsorbents and waste management methods are gaining more attention. In the current study, rubber wastes derived from dipping tank coagulum (DTC) in the glove manufacturing industry were converted into a novel polymeric-adsorbent via a simple sulfonation reaction with concentrated sulphuric acid and was used for the adsorption of methylene blue (MB) dye from aqueous solutions commonly found in contaminated waters. FT-IR, EDX, FESEM, and BET techniques were used to characterize the rubber waste before and after modification. The highest MB removal efficiency of 99.03% was achieved in the condition of initial concentration, adsorbent dosage, pH, contact time, and temperature were 15 mg/L, 30 mg, pH 7, 300 min, and 25 °C, respectively. The adsorption of MB was analyzed using experimental data fitted in a monolayer isotherms model with a maximum adsorption capacity of 119 mg/g. The kinetic model was revealed to agree with the pseudo-second-order kinetic model. Furthermore, SRW retained 90.45% of the removal percentage after four cycles of the repeated adsorption-desorption process. Conclusively, these findings suggest that rubber waste could be a suitable low-cost adsorbent to remove organic dyes from polluted water.
Codoping Effect of Nitrogen (N) to Iron (Fe) Doped Zirconium Titanate (ZrTiO4) Composite toward Its Visible Light Responsiveness as Photocatalysts
Authors: Hayati Rizka , Kurniawan Rian , Prasetyo Niko , Sudiono Sri , Syoufian Akhmad
Published: June 2022

Iron (Fe) and nitrogen (N) were introduced as dopants into zirconium titanate (ZrTiO4) in order to study the codoping effects of nitrogen on iron-doped zirconium titanate (Fe,N-codoped ZrTiO4) composite. Titanium tetraisopropoxide (TTIP), zirconia (ZrO2), urea, and iron(II) sulfate heptahydrate were used as the source of TiO2, semiconductor supports, source of nitrogen, and iron, respectively. A specific amount of iron (1, 3, 5, 7, and 9 wt.%) and a fixed nitrogen content (10 wt.%) were doped into the ZrTiO4 lattice. Various calcination temperatures (from 500 to 900 °C) were also applied to investigate the crystal structure of the composite. The composites were characterized by X-ray powder diffractometer (XRD), Fourier-transform infrared spectrophotometer (FT-IR), scanning electron microscope with energy dispersive X-Ray spectrometer (SEM-EDX), and specular reflectance UV-Vis (SR-UV). The lowest bandgap energy of 2.62 eV was obtained in the composite with 3 wt.% of Fe and 10 wt.% of N calcined at 500 °C.
Effect of Ascorbic Acid Concentration on the Stability of Tartrate-Capped Silver Nanoparticles
Authors: Janah Indah Miftakhul , Roto Roto , Siswanta Dwi
Published: June 2022

In this work, tartrate-capped silver nanoparticles (AgNPs) by reducing Ag+ ions into Ag0 using L-ascorbic acid and capping disodium tartrate have been prepared. The reaction was carried out at room temperature in an alkaline medium of pH 11 to obtain a rapid and one-step green synthesis method. The effect of L-ascorbic acid concentration on the synthesis preparation was studied to investigate their impact on the particle size, morphology, and stability of the AgNPs. The obtained tartrate capped AgNPs have SPR absorbance in 390–410 nm. They have a spherical shape, as confirmed by TEM. Increasing L-ascorbic acid concentrations from 25 mM to 100 and 200 mM leads to the 27, 17, and 11 nm particle size distributions. They give the zeta potential of –33.5, –20.8, and –21.3, respectively. After a week, the decreasing absorbance peaks were 0.151, 0.0105, and 0.336 a.u. The optimum L-ascorbic acid concentration was obtained at 100 mM, indicated by the smallest FWHM point. Thus, we may conclude that lower or higher levels of reducing agents resulted in low stability. Therefore, controlling L-ascorbic acid concentration is an important parameter. A sufficient concentration and an appropriate capping agent can produce good nanoparticle stability essential for further application.
PERBANDINGAN PENGUKURAN TDT ORDE 4 MENGGUNAKAN GNSS METODE RTK NTRIP DAN RADIO
Authors: Mahendra Gani , Panuntun Hidayat
Published: June 2022

RTK (Real Time Kinematic) merupakan salah satu metode pengukuran dengan menggunakan GNSS yang saat ini sering digunakan di Indonesia. Berdasarkan pengiriman koreksinya RTK dibagi menjadi dua yaitu RTK NTRIP dan Radio. RTK NTRIP memanfaatkan koneksi internet dalam pengiriman koreksinya. RTK Radio memanfaatkan gelombang radio dalam pengiriman koreksinya. Berdasarkan perbedaan tersebut RTK NTRIP dan Radio memiliki keunggulan dan kekurangan saat digunakan untuk pengukuran. Tujuan dari penelitian ini untuk mengetahui metode terbaik yang dapat digunakan untuk pengukuran di lapangan. Penelitian ini dilakukan dengan melakukan pengukuran pada TDT orde 4 di desa Banyuraden kecamatan Gamping Kabupaten Sleman Provinsi Daerah Istimewa Yogyakarta. Koordinat TDT orde 4 yang diperoleh dari hasil pengukuran menggunakan metode RTK NTRIP dan Radio kemudian dibandingkan dan diuji apakah secara statistik perbedaan hasil antara kedua metode tersebut signifikan. Selain itu, standar deviasi hasil pengukuran dengan metode RTK NTRIP dan Radio digunakan untuk evaluasi pengukuran manakah yang memberikan presisi dan akurasi yang paling tinggi. Hasil standar deviasi menunjukkan bahwa metode RTK Radio memiliki tingkat presisi yang paling tinggi daripada metode RTK NTRIP. Selain melihat nilai standar deviasi, selisih antara buku tugu dan kedua metode menunjukkan bahwa hasil selisih RTK Radio yang mendekati nilai koordinat yang ada di buku tugu. Dari hasil tersebut dapat disimpulkan bahwa RTK Radio baik digunakan pada daerah yang rapat seperti di desa Banyuraden, kecamatan Gamping, Kabupaten Sleman, provinsi Daerah Istimewa Yogyakarta.
The Anti-Racist Compliance
Authors: Muniz Veyzon Campos
Published: June 2022

Anti-racist compliance is the appropriate set of integrity and compliance techniques for the creation of inclusive institutional environments, capable of diversity and free from racism. Understanding its constitution depends on recognizing the human right to development, in a practical way, and the role of institutions in its implementation, as well as the negative impacts of racism on corporate governance. Thus, it can be said that institutional designs of conformity and integrity committed to the fight against racism give rise to the achievement of sustainable development, human rights and democracy.
Probióticos presentes en bebidas fermentadas mexicanas
Authors: Cerero-Calvo Cynthiarel , Sánchez-Medina Marco Antonio , Pérez-Santiago Alma Dolores , Matías-Pérez Diana , García-Montalvo Iván Antonio
Published: June 2022

En México, desde la época prehispánica se producen una gran variedad de bebidas fermentadas, que en la actualidad son consideradas tradicionales y aunque su contenido ha sido escasamente investigado, hay estudios que reportan sus efectos benéficos a la salud del consumidor debido no sólo a la presencia y acción microbiana/probiótica, sino también a la de múltiples compuestos de importancia biológica. El objetivo de esta revisión es destacar la información disponible de cuatro bebidas seleccionadas, los probióticos presentes en ellas, el mecanismo de acción de estos y sus posibles aplicaciones en la salud humana; por lo que se compiló la información científica, sobre los probióticos, disponible en las bases de datos como: Pubmed, Science Direct, Web of Science, SciELO, Redalyc, Dialnet, Springer y Google Académico. En conclusión, son necesarios más estudios y ensayos clínicos, en humanos, que apoyen su aplicación biomédica ante algunas patologías que afectan a la salud pública.
Prebióticos y microbiota: Factores clave en el síndrome metabólico
Authors: Peña-Montes Carolina , Ramírez-Higuera Abril , Morales-Cano Karla Lizzeth , Lagunes-Vela Kalid Gabriela , Mendoza-García Patricia G. , Oliart-Ros Rosa María
Published: June 2022

El síndrome metabólico (SMet) es un problema complejo de salud pública mundial, enfermedades relacionadas con él son causa de muerte que en el año 2020 fue del 43%. El tratamiento y la prevención del SMet sin el uso de fármacos tiene un impacto significativo al abordar el problema de forma integral. Esencialmente con cambios en el estilo de vida, al modificar la dieta incluyendo compuestos bioactivos que favorecen a la microbiota intestinal (MI) y un aumento de la actividad física. Debido al papel de la (MI) en la patogénesis del SMet, en los últimos años se han incorporado a la dieta probióticos y prebióticos individualmente o mezclados con alimentos o suplementos. La presente revisión define el papel de los prebióticos en la modificación de la microbiota para el tratamiento y la prevención de este padecimiento.
Formación Archivística en Colombia: Una mirada comparativa desde la política pública nacional sobre gestión documental
Authors: Vallejo Sierra Ruth Helena , Pirela Morillo Johann Enrique
Published: June 2022

Se analiza la formación archivística en Colombia, sobre la base de una perspectiva evolutiva y de actualidad, estableciendo semejanzas o diferencias entre contenidos disciplinares y la estructura algorítmica del currículo de los programas académicos que forman profesionales en esta disciplina. El enfoque cualitativo, con método documental y tipo de investigación comparativa fueron los elementos centrales de la metodología, utilizando como referente el Modelo de Gestión Documental y Administración de Archivos, el cual constituye una de las políticas públicas nacionales que orientan la implementación de la función archivística en dicho país. Los principales resultados muestran diferentes grados de articulación de los programas, lo cual lleva a la conclusión de que se requiere transitar hacia procesos de armonización curricular para la formación de los archivistas en Colombia.
Bankruptcy Detection on Unbalanced Data with Various Machine Learning Models
Authors: Tarun Kommareddy
Published: June 2022

Abstract: Machine learning has come a way long from past decades and the use of machine learning and machine learning models has been rapidly increasing in various fields. Today machine learning is playing a critical role in many streams especially finance. Bankruptcy is a technical term used to describe whether a company can run its operations in the future because of its losses or bad debts. The paper focuses on delivering a machine learning algorithmic approach to detect a company's state of bankruptcy based on the available data. The project implements a study on a dataset of companies in a specific period and By applying various machine learning algorithms like logistic regression, random forest, and artificial neural networks. Keywords: Machine learning, logistic regression, random forest, artificial neural networks