bluuebunny/crossref_metadata_2025 huggingface dataset:
The Contribution of a Body Scan Mindfulness Meditation to Effectiveness of Internet-Delivered CBT for Insomnia in Adolescents
Authors: de Bruin Eduard J. , Meijer AnneMarie , Bögels Susan M.
Published: January 2020

Objectives

Insomnia is highly prevalent among adolescents, with severe consequences for daily life, including mental disorders. Cognitive behavioral therapy for insomnia (CBTI) can be effective in internet-delivered and face-to-face modalities. However, it is yet unclear what the contribution is of mindfulness-based techniques to the effectiveness of traditional CBTI. The present study investigated whether use of a body scan mindfulness meditation influenced the effectiveness of CBTI for adolescents.

Methods

Adolescents who had received 6 weeks of internet CBTI were divided into a group who had practiced a body scan meditation (N = 26, age M = 15.33 years, SD = 1.42, 77% girls) and a group who had not (N = 28, age M = 15.64 years, SD = 1.80, 82% girls). Differences between the groups were analyzed for subjective and objective sleep outcomes from baseline to post-treatment and to 2-month follow-up.

Results

Moderate to large effect size improvements appeared for sleep parameters from 7-day actigraphy and sleep logs, and large effect size decreases of self-reported symptoms of insomnia and chronic sleep reduction, at post-treatment for both groups. Improvements were maintained at follow-up. However, where the non-body scan group showed no significant change of wake after sleep onset from actigraphy, and self-reported shortness of sleep and irritation, there were medium effect size improvements of these outcomes in the body scan group.

Conclusions

These results indicate that the use of a body scan mindfulness meditation in CBTI may have an additional positive effect on sleep, above and beyond traditional CBTI techniques.
The academic hedge Part I: Modal tuning in your research writing
Authors: Lingard Lorelei
Published: January 2020

None
Shiga-Toxin E. coli Hemolytic Uremic Syndrome: Review of Management and Long-term Outcome
Authors: Harkins V. J. , McAllister D. A. , Reynolds B. C.
Published: January 2020

Purpose of Review

We review the pathophysiology of Shiga-Toxin Enteropathogenic–Hemolytic Uremic Syndrome (STEC-HUS), strategies to ameliorate or prevent evolution of STEC-HUS, management and the improved recognition of long-term adverse outcomes.

Recent Findings

Following on from the preclinical evidence of a role for the complement system in STEC-HUS, the use of complement blocking agents has been the major focus of most recent clinical research. Novel therapies to prevent or lessen HUS have yet to enter the clinical arena. The long-term outcomes of STEC-HUS, similarly to other causes of AKI, are not as benign as previously thought.

Optimizing supportive care in STEC-HUS is the only current recommended treatment. The administration of early isotonic fluids may reduce the severity and duration of STEC-HUS. The role of complement blockade in the management of STEC-HUS remains unclear. The long-term sequelae from STEC-HUS are significant and patients with apparent full renal recovery remain at risk.
Nitrogen-doped Carbon Nanospheres-Modified Graphitic Carbon Nitride with Outstanding Photocatalytic Activity
Authors: Liu Qiaoran , Tian Hao , Dai Zhenghua , Sun Hongqi , Liu Jian , Ao Zhimin , Wang Shaobin , Han Chen , Liu Shaomin
Published: January 2020

Metals and metal oxides are widely used as photo/electro-catalysts for environmental remediation. However, there are many issues related to these metal-based catalysts for practical applications, such as high cost and detrimental environmental impact due to metal leaching. Carbon-based catalysts have the potential to overcome these limitations. In this study, monodisperse nitrogen-doped carbon nanospheres (NCs) were synthesized and loaded onto graphitic carbon nitride (g-C3N4, GCN) via a facile hydrothermal method for photocatalytic removal of sulfachloropyridazine (SCP). The prepared metal-free GCN-NC exhibited remarkably enhanced efficiency in SCP degradation. The nitrogen content in NC critically influences the physicochemical properties and performances of the resultant hybrids. The optimum nitrogen doping concentration was identified at 6.0 wt%. The SCP removal rates can be improved by a factor of 4.7 and 3.2, under UV and visible lights, by the GCN-NC composite due to the enhanced charge mobility and visible light harvesting. The mechanism of the improved photocatalytic performance and band structure alternation were further investigated by density functional theory (DFT) calculations. The DFT results confirm the high capability of the GCN-NC hybrids to activate the electron–hole pairs by reducing the band gap energy and efficiently separating electron/hole pairs. Superoxide and hydroxyl radicals are subsequently produced, leading to the efficient SCP removal.
Biomimetic Superlyophobic Metallic Surfaces: Focusing on Their Fabrication and Applications
Authors: Lian Zhongxu , Xu Jinkai , Wang Zuobin , Yu Huadong
Published: January 2020

Metals are indispensable engineered materials for day-to-day life. Researches focused on metallic surfaces with superlyophobicity (superhydrophobicity, superoleophobicity, underwater superoleophobicity and slippery characteristic) have attracted much attention recently. Nature is a magician that gives each organic life a unique advantage. Researchers have created a large number of biomimetic superlyophobic metallic surfaces through various approaches. These biomimetic superlyophobic metallic surfaces exhibit advantages in many applications, such as self-cleaning, corrosion resistance, anti-icing, and drag reduction. In this review, the specific fabrication and applications of biomimetic superlyophobic metallic surfaces were reported. The remaining challenges and future outlook of biomimetic superlyophobic metallic surfaces were preliminarily analyzed. It is hoped that the review will be essential for broadening the scope of potential applications of metals and providing a powerful reference for future research on metal-based advanced functional materials.
The Challenge of Evolution to Religion
Authors: De Smedt Johan , De Cruz Helen
Published: January 2020

This Element focuses on three challenges of evolution to religion: teleology, human origins, and the evolution of religion itself. First, religious worldviews tend to presuppose a teleological understanding of the origins of living things, but scientists mostly understand evolution as non-teleological. Second, religious and scientific accounts of human origins do not align in a straightforward sense. Third, evolutionary explanations of religion, including religious beliefs and practices, may cast doubt on their justification. We show how these tensions arise and offer potential responses for religion. Individual religions can meet these challenges, if some of their metaphysical assumptions are adapted or abandoned.
The MV “Norstar” Case (Panama v. Italy)
Authors: Miles Cameron
Published: January 2020

In the MV “Norstar” Case (Norstar Case), the International Tribunal for the Law of the Sea (ITLOS) produced two reasoned decisions. In the first, the Tribunal established jurisdiction over the relevant dispute and the admissibility of Panama's claims. In the second, it found that Italy had violated Panama's right to freedom of navigation on the high seas. In the latter decision, the Tribunal relied on an expansive understanding of flag state jurisdiction—prompting a vociferous joint dissent by seven of its twenty-three judges. The majority's understanding of the jurisdictional exclusivity of the flag state as extending to prescriptive as well as enforcement jurisdiction is a significant expansion of flag state rights—and will have a corresponding impact on the way that shipping is regulated internationally.
Fostering a community of PHAROS scholars through the adoption of open standards
Authors: Delmas-Glass Emmanuelle , Sanderson Robert
Published: January 2020

The PHAROS consortium is adopting the Linked Art data model to make its descriptions of photo archives collections available as Linked Open Data to further support scholars in their research. Linked Art is both a community and a data model. As an international community, it works together to create a shared data model to describe art. As a data model, it is a data profile of the CIDOC Conceptual Reference Model and using Linked Open Data techniques. The goal of Linked Art is to enable museums and developers to engage in LOD initiatives more easily by providing them with shared data modelling decisions and consistent design principles.
A ‘collection of broken dreams’? Making the Paul Mellon Centre's photo archive accessible in 2019 and beyond
Authors: Scutt Thomas , Turner Sarah Victoria
Published: January 2020

This article focuses on the research that the Paul Mellon Centre for Studies in British Art has conducted with users in the process of digitising its photo archive. Converting this resource from photographs mounted on card to digital assets appears, at first glance, a relatively straightforward digitisation project. However, the questions, challenges and issues raised by this project have prompted us to not only focus on the ‘how’ (the process of this conversion), but also the ‘why’. As the project has progressed, these questions about why we are digitising our photo archive and what benefit/s this will have to users and its impact on the field of British art history in the future have grown more voluble.
Consistent ice and open water classification combining historical synthetic aperture radar satellite images from ERS-1/2, Envisat ASAR, RADARSAT-2 and Sentinel-1A/B
Authors: Johansson A. Malin , Malnes Eirik , Gerland Sebastian , Cristea Anca , Doulgeris Anthony P. , Divine Dmitry V. , Pavlova Olga , Lauknes Tom Rune
Published: January 2020

Synthetic Aperture Radar (SAR) satellite images are used to monitor Arctic sea ice, with systematic data records dating back to 1991. We propose a semi-supervised classification method that separates open water from sea ice and can utilise ERS-1/2, Envisat ASAR, RADARSAT-2 and Sentinel-1 SAR images. The classification combines automatic segmentation with a manual segment selection stage. The segmentation algorithm requires only the backscatter intensities and incidence angle values as input, therefore can be used to establish a consistent decadal sea ice record. In this study we investigate the sea ice conditions in two Svalbard fjords, Kongsfjorden and Rijpfjorden. Both fjords have a seasonal ice cover, though Rijpfjorden has a longer sea ice season. The satellite image dataset has weekly to daily records from 2002 until now, and less frequent records between 1991 and 2002. Time overlap between different sensors is investigated to ensure consistency in the reported sea ice cover. The classification results have been compared to high-resolution SAR data as well as in-situ measurements and sea ice maps from Ny-Ålesund. For both fjords the length of the sea ice season has shortened since 2002 and for Kongsfjorden the maximum sea ice coverage is significantly lower after 2006.
Income growth is unlikely to help, but we can learn from international comparisons
Authors: KAPTEYN ARIE
Published: January 2020

The paper by Paul Frijters, Andrew E. Clark, Christian Krekel and Richard Layard is a timely attempt to move subjective wellbeing (SWB) to the center of policy attention. I am essentially making three points. First of all, for this enterprise to be successful, one needs to have very solid evidence on what improves SWB and what does not. If policies are proposed that turn out not to improve SWB (or do so far less than expected), then the enterprise of making SWB the centerpiece of policy may be discredited before it has begun in earnest. As an example of this concern, my second point is that raising the incomes of all may have very disappointing effects on measured SWB. My third point is that at the current state of knowledge, the most fertile ground for learning about what works is to exploit international comparisons of policies and how these affect a nation's SWB.
Wellbeing measures of mortality risks: life-cycle contradictions and ordinal index challenges
Authors: VISCUSI W. KIP
Published: January 2020

The value of a statistical life (VSL) monetizes the expected loss in wellbeing associated with the risk of death. The utility loss resulting from a fatality is central to the empirical framework for estimating the VSL. The VSL trajectory over the life cycle exhibits an inverted-U shape, following a trajectory similar to that of lifetime patterns of consumption. The U-shaped pattern displayed by happiness measures over the life cycle is the opposite of the inverted-U shape pattern displayed by the VSL. It is consequently inappropriate to use happiness measures as ordinal ranking substitutes for the VSL for the purposes of estimating the benefits of mortality risk reduction. Compared to ordinal wellbeing scales, the VSL also offers a variety of additional capabilities by providing a cardinal index of the unit benefits for changes in mortality risks.
Rehabilitating an Empire: Humanitarian Collusion with the Colonial State during the Kenyan Emergency, ca. 1954–1960
Authors: Baughan Emily
Published: January 2020

During the Kenyan Emergency of 1952–1960, one of the most violent episodes in the history of the British Empire, humanitarian organizations colluded with the colonial state to shore up British power. This article examines how aid agencies that claimed to exemplify the progressive internationalism of the postwar period participated in colonial violence. Far from condemning the brutality of the imprisonment and torture during the Kenyan Emergency, aid organizations were deeply implicated in parallel projects for women and children that sought to achieve the same objectives: the remaking of Kikuyu hearts and minds and the weakening of anticolonial resistance. Far from acting as a check on colonial violence in an era of burgeoning rights discourses in 1950s Kenya, self-proclaimed “impartial” internationalist organizations, while claiming to uphold values of universal humanity, worked as auxiliaries to the colonial counterinsurgency. Taking their cue from military counterinsurgency in 1950s Malaya, humanitarians sought to win “hearts and minds” and undertook material provision for imprisoned anticolonial activists and their families on behalf of the colonial state. They did so by importing new humanitarian expertise developed in wartime Europe and adapting it to fit within racist, colonial norms. In providing this allegedly impartial expertise, humanitarian organizations lent credence to the myth that rehabilitation in Kenya was a progressive program enacted by a liberal empire to modernize its subjects, rather than a ruthless attempt to stymie anticolonial resistance by any means necessary. In this case, postwar humanitarian internationalism did not challenge colonial brutality but enabled it.
The Bicentenary of Queen Victoria
Authors: Taylor Miles
Published: January 2020

The past year, 2019, was the bicentenary of the birth of Queen Victoria. Since 2001, the centenary of her death, much has changed in the scholarship about the British queen. Her own journals and correspondence are more available for researchers. European monarchies are now being taken seriously as historical topics. There is also less agreement about the Victorian era as a distinct period of study, leaving Victoria's own relationship with the era she eponymizes less certain. With these changing perspectives in mind, this article looks at six recent books about Victoria (four biographies, one study of royal matchmaking, and one edited volume) in order to reassess her reign. The article is focused on three themes: Queen Victoria as a female monarch, her role in building a dynastic empire, and her prerogative—how she influenced the politics of church and state. The article concludes by warning that biography is not the medium best suited for taking advantage of all the new historical contexts for understanding Queen Victoria's life.
Ordovician turbidites and black shales of Bennett Island (De Long Islands, Russian Arctic), and their significance for Arctic correlations and palaeogeography
Authors: Danukalova Maria K. , Kuzmichev Alexander B. , Sennikov Nikolai V. , Tolmacheva Tatiana Yu.
Published: January 2020

Bennett Island stands alone in a remote part of the Arctic and information on its geology is essential to ascertain relations with other terranes in order to restore the early Palaeozoic Arctic palaeogeography. Lower Palaeozoic sedimentary rocks throughout the island were studied thoroughly for the first time. The Ordovician section (> 1.1 km thick) comprises three units: Tremadocian, lowest Floian black shale (130–140 m); Floian, lower Dapingian carbonate turbidite (> 250 m); and Dapingian, lower Darriwilian siliciclastic turbidite (> 730 m). Ordovician deposits conformably overlie Cambrian rocks deposited within the Siberian shelf, as shown earlier. Most of the Ordovician succession was formed in a deep trough that received carbonate debris from a nearby carbonate platform and silicate material from a distant landmass located to the NE (present coordinates). The Bennett Island Ordovician rocks have much in common with those of both the Central and Northern Taimyr belts. It could be tentatively suggested that both belts merged at their eastern continuation in the vicinity of De Long Islands. The whole system probably extends further eastwards. The Ordovician facies patterns and faunal assemblages in the New Siberian Islands are notably similar to those of northwestern Alaska, where the same lateral transition from turbidites to shelf limestones was reported.
Gender inequality and sexual height dimorphism in Chile
Authors: Castellucci Héctor , Viviani Carlos , Boccardo Giorgio , Arezes Pedro , Bartsch Ángelo , Martínez Marta , Aparici Verónica , Molenbroek Johan F.M. , Bragança Sara
Published: January 2020

Chile has experienced significant improvements in its economy; thus, a secular trend in height has been observed in its population. Gender equality has also improved hand in hand with active policies addressing the gender gap in several dimensions (work, education, health) and overall economic improvement. This study examined changes in sexual height dimorphism in four samples of Chilean male and female working-age subjects and attempted to establish associations with gender equality and welfare. Sexual height dimorphism was calculated and compared with gender equality and overall welfare indicators between 1955 and 1995. Sexual height dimorphism reduction was seen to be strongly associated with greater gender equality and some general welfare indicators, such as the infant mortality rate. Gross domestic productper capitawas not associated with sexual height dimorphism, but it showed significant associations with gender equality indicators. Overall, the gender gap has been reduced in Chile, which can be observed through improvements in gender equality indicators and a reduction in height dimorphism, mainly in areas associated with women’s health. However, gender equality is still far behind in terms of female labour participation and women in political power, which require attention and further improvements.
Technological properties of indigenous Lactococcus lactis strains isolated from Lait caillé, a spontaneous fermented milk from Burkina Faso
Authors: Bayili Geoffroy Romaric , Johansen Pernille Greve , Hougaard Anni Bygvrå , Diawara Bréhima , Ouedraogo Georges Anicet , Jespersen Lene , Sawadogo-Lingani Hagretou
Published: January 2020

The experiments reported in this research paper aimed to determine the technological properties of indigenous Lactococcus lactis strains isolated from Lait caillé, a spontaneous fermented milk, from the perspective of starter culture development. Fermentations were conducted to determine the acidification patterns. The ropy character, growth in 0.04 g/ml NaCl and citrate metabolism were additionally tested. Furthermore, the rheological properties of samples from selected strains and the impact of cold storage were evaluated. Based on the rate of acidification, the indigenous strains were divided into 2 groups depending on their fermentation time, i.e. 10–13 h (fast acidifier), and up to 72 h (slow acidifier), respectively. The physiological tests suggested that most of these strains produced exopolysaccharides but none could ferment citrate. The flow properties of the samples inoculated by the fast acidifier strains showed a time-dependent shear thinning behaviour, while their viscoelastic properties corresponded structurally to those of weak gels. Cold storage decreased the viscosity and CFU counts for most of the indigenous strains tested. This study is a step towards the definition of starter cultures for African spontaneous fermented milks such as Lait caillé.
E-commerce promotes trade in invasive turtles in China
Authors: Liu Sha , Newman Chris , Buesching Christina D. , Macdonald David W. , Zhang Yu , Zhang Kai-Jie , Li Feng , Zhou Zhao-Min
Published: January 2020

Freshwater habitats in China are potentially suitable for invasive alien turtle species and, consequently, raising turtles in aquaculture facilities and the trade in turtles this supplies pose risks to habitats and native wetland communities when exotic turtles escape or are released deliberately. Online trade (e-commerce) is making an increasing contribution to turtle sales in China, seemingly driving demand and thus potentially exacerbating the risk of release. We document the scale and spatial pattern of online sales of non-native turtles over 90 days on China's Taobao.com e-commerce site. The majority of sales were in the ecologically sensitive middle and lower Yangtze river basin (82.35% of > 840,000 slider turtles Trachemys scripta elegans, and 68.26% of > 100,000 snapping turtles, Chelydridae spp.). These species are native to the Americas. Concurrently, over 2008–2018, we found 104 mentions of feral turtle issues listed on Baidu News where, among the 53 prefectures mentioned, issues with invasive turtle populations also focused predominantly in the middle and lower Yangtze river basin. Although circumstantial, this association suggests that the substantial online sale of alien turtles could be having detrimental effects in China's Yangtze river basin. It is important to safeguard these wetland habitats, which are of global importance, by improving policies for detecting and regulating invasive alien turtle issues and by warning consumers about the ecological hazard of their purchases.
Closing the cycle of innovation in healthcare in Europe
Authors: Hulstaert Frank , Ruether Alric , Demotes Jacques , Melien Øyvind
Published: January 2020

Pragmatic or practice-oriented comparative effectiveness trials may be conducted to fill the evidence gaps that are revealed after the private sector has performed the trials needed for bringing their product to the market. A tool of increasing importance to identify such evidence gaps is resulting from health technology assessments (HTA) whereby the data derived from clinical research are examined in a systematic manner with reference to effect, safety, as well as additional parameters. Practice-oriented trials are informative for healthcare decision makers, practice-changing and may even be cost-saving for the healthcare payers. There are however only a limited number of funding sources for such trials. Public and private healthcare payers should stimulate the conduct of practice-oriented trials in their effort to maximize patient benefit within the limitation of the available resources. Pragmatic randomized trials can be performed at low cost when based on existing coded electronic health records and as well health registries. Public health decision makers are increasingly taking advantage of results from health technology assessments to support priority setting. In accordance with this it would appear reasonable that decision makers should get more involved in priority setting and funding also in the field of clinical research in order to provide further evidence needed for assessments, reassessments, and subsequent qualified decisions and resource allocations in health care. A closer dialogue and collaboration between the clinical research and HTA communities would facilitate a more efficient utilization of such opportunities.
Såli (Micronesian starling –Aplonis opaca) as a key seed dispersal agent across a tropical archipelago
Authors: Pollock Henry S. , Fricke Evan C. , Rehm Evan M. , Kastner Martin , Suckow Nicole , Savidge Julie A. , Rogers Haldre S.
Published: January 2020

Seed dispersal is an important ecological process that structures plant communities and influences ecosystem functioning. Loss of animal dispersers therefore poses a serious threat to forest ecosystems, particularly in the tropics where zoochory predominates. A prominent example is the near-total extinction of seed dispersers on the tropical island of Guam following the accidental introduction of the invasive brown tree snake (Boiga irregularis), negatively impacting seedling recruitment and forest regeneration. We investigated frugivory by a remnant population of Såli (Micronesian starling –Aplonis opaca) on Guam and two other island populations (Rota, Saipan) to evaluate their ecological role as a seed disperser in the Mariana archipelago. Using a combination of behavioural observations, nest contents and fecal samples, we documented frugivory of 37 plant species. Native plants comprised the majority (66%) of all species and 90% of all seeds identified in fecal and nest contents. Diet was highly similar across age classes and sampling years. In addition, plant species consumed by Såli comprised 88% of bird-dispersed adult trees and 54% of all adult trees in long-term forest monitoring plots, demonstrating the Såli’s broad diet and potential for restoring native forests. Overall, we provide the most comprehensive assessment to date of frugivory by the Såli and confirm its importance as a seed disperser on Guam and throughout the Marianas.
Greater tree community structure complexity in sacred forest compared to reserve forest land tenure systems in eastern India
Authors: Rath Subhani , Banerjee Subham , John Robert
Published: January 2020

Sacred forests are small patches of forest that are preserved and protected from human exploitation. Although they are identified primarily for spiritual or religious purposes, their contribution to biodiversity conservation has been widely debated. Sacred sites are known to harbour greater biodiversity compared to exploited forests, but the patterns are not well known. We studied tree diversity in a remote forested location in eastern India where sacred forests and reserve forests used by people are present. Tree data from eight sacred forest sites and nine reserve forest sites showed that species richness was significantly greater in sacred forests; species diversity and evenness tended to be greater, but these were not statistically significant. Basal area (a measure of aboveground biomass) was significantly greater, mainly due to the greater density of large trees. There were significant departures from the theoretical expectation of stem size density distributions under pure asymmetric competition for both land tenures, which indicated that extraneous mortality increased death rates of large trees under both regimes, but sacred forests had a greater range of stem sizes. Our results suggest that sacred forests can contribute to biodiversity conservation by preserving greater tree diversity than forests subject to human use.
The Political Philosophy of Henry Sidgwick
Authors: Miller David
Published: January 2020

Why has Sidgwick's political philosophy fallen into oblivion while his ethics continues to be celebrated? Not because his performance in that field was inferior, nor because his choice of topics has become outdated, nor because his conclusions were largely conservative. Instead the problem stems from the weight he attached to common sentiments and beliefs in his application of the utility principle, illustrated by his treatment of topics such as secession and colonialism. Moreover hisElements of Politicsis arranged in such a way that he never has to confront the basic question of what makes states legitimate. This means that neither political moralists, who want to see the utility principle applied in more radical fashion, nor political realists, for whom the problem of establishing political order is central, find much to commend in his political philosophy.
REGIONAL CONVERGENCE IN LARGE EMERGING ECONOMIES: A DISTRIBUTION DYNAMICS APPROACH
Authors: Tochkov Kiril
Published: January 2020

Rapid growth in large emerging economies has been spread unequally across their regions leading to growing income disparities. This paper examines the distribution of regional output per capita and the evolution of its shape in Brazil, China, India, and Russia from the mid-1990s to the mid-2010s. A comparative analysis of convergence is conducted using a nonparametric methodology. The results reveal different distribution dynamics across the four economies. Chinese regions with below-median output per capita have the highest probability of transitioning toward higher-income levels, while their Brazilian counterparts are trapped at the bottom of the distribution. Although India has the lowest and Russia one of the highest regional income inequalities, they display similar divergence patterns exemplified by high persistence at both ends of the distribution. Our findings indicate that government spending and the rule of law are the major driving forces behind regional convergence, except in Russia where they have the opposite effect. Innovation and property rights also promote convergence in China, but cause regional divergence in India.
Angst vor medizinischen Untersuchungen am Beispiel der Zahnbehandlungsangst: Wie hilfreich ist der Einsatz verhaltenstherapeutischer Techniken bei Vorschulkindern?
Authors: Pfau Dagmar , Stratigaki Eirini , Verna Carlaalberta , Stadler Christina
Published: January 2020

Zusammenfassung. Fragestellung: Zahnbehandlungsangst ist ein häufiges Problem im Rahmen der zahnärztlichen Behandlung bei Vorschulkindern. Zur Angstreduktion werden Kontrollmöglichkeiten eingesetzt, die es den Kindern erlauben, die Behandlung zu unterbrechen. Ziel der Studie war der Vergleich zweier Kontrollmöglichkeiten im Hinblick auf Angstreduktion und Behandlungserfolg. Methodik: 60 Vorschulkinder (3–6 Jahre) mit Zahnbehandlungsangst wurden einer professionellen Zahnreinigung (PZR) mit Tell-Show-Do-Methode (TSDM) unterzogen. Es erfolgte eine Randomisation in die Standardgruppe, in der eine Unterbrechung der Behandlung uneingeschränkt möglich war (S-K), oder die Gruppe mit limitierter Möglichkeit zur Unterbrechung (L-K). Die Wirksamkeit der Kontrollmöglichkeit auf die Reduktion der Zahnbehandlungsangst wurde objektiv durch die Pulsrate und ergänzend durch Selbsteinschätzung gemessen. Ergebnis: Sowohl in der S-K- als auch in der L-K-Bedingung kam es zu einem signifikanten Abfall der Pulsrate und beide Gruppen unterschieden sich weder hinsichtlich der erfassten physiologischen Erregung noch im zahnärztlichen Behandlungsergebnis. Bei allen Kindern war jedoch nach Anwendung der TSDM ein Anstieg der Pulsrate zu beobachten. Schlussfolgerung: Die Ergebnisse deuten darauf hin, dass auch eine eingeschränkte Möglichkeit der Behandlungsunterbrechung nicht mit einer höheren Belastung für die behandelten Kinder verbunden ist. Weitere Studien sind notwendig, um den Nutzen der neuen Methoden unabhängig von TSDM zu untersuchen.
China's Trade‐Off Between Economic Benefits and Sulfur Dioxide Emissions in Changing Global Trade
Authors: Wang Feng , Li Yongyuan , Zhang Wei , He Pan , Jiang Ling , Cai Beiming , Zhang Jing , Zhang Pengyan , Pan Haoran , Jiang Hongqiang
Published: January 2020

China has been suffering from air quality degradation since its ascension into the World Trade Organization in 2001. The unequal exchange that occurs with international trade—that is, developed countries obtaining larger shares of trade‐related value added relative to the shares of trade‐related air pollution incurred locally—may obstruct the greening of global supply chains. In this study, we conduct a multi‐regional input‐output analysis to examine the change in the distribution of economic benefits and sulfur dioxide emissions underlying China's international trade from 2002 to 2015. The results show that both net trade‐related economic benefits and SO2 emissions in China rapidly increased from 2002 to 2007 and then decelerated after 2007 due to changes in China's green development strategy. In the past 13 years, China has suffered from economic‐environmental inequality due to trade with most developed countries, for example, the United States, the European Union, East Asia, and Canada. East Asia, particularly Japan and South Korea, became both an economic and environmental winner while trading with China in 2015. China has also outsourced emissions to less developed regions, such as Sub‐Saharan Africa. We propose policy implications to further reduce the economic‐environmental inequality underlying China's international trade.
Climate Assessment Moves Local
Authors: Holmes K. J. , Wender B. A. , Weisenmiller R. , Doughman P. , Kerxhalli‐Kleinfield M.
Published: January 2020

State and local governments, businesses, community organizations, and the general public are taking an increasingly significant role in climate impact assessment. Driven by impacts to constituents and customers and threats to human health, essential services, and property values, local organizations are on the front lines of responding to climate change. National and international efforts such as the U.S. National Climate Assessment and Intergovernmental Panel on Climate Change provide fundamental scientific understanding as well as methods and modeling tools. Subnational climate assessments can build on this foundation and tailor models and analyses to specific local or decision contexts. However, subnational climate assessment and adaptation presents new scientific and research challenges, such as those related to downscaling climate models, simulating extreme events, and understanding local values and institutional practices. As state, local, and sectoral assessments become more common across the nation, there is a critical opportunity to share learnings and identify challenges and pitfalls. Building off a National Academies of Sciences, Engineering, and Medicine activity focusing exclusively on subnational climate assessment, we consider the methods and results from a variety of examples to synthesize findings about current practices and the future of subnational climate assessment.
A Multiscale Precipitation Forecasting Framework: Linking Teleconnections and Climate Dipoles to Seasonal and 24‐hr Extreme Rainfall Prediction
Authors: Kim Yong‐Tak , So Byung‐Jin , Kwon Hyun‐Han , Lall Upmanu
Published: January 2020

We develop a hybrid statistical forecasting model for the simultaneous season‐ahead forecasting of both seasonal rainfall and the 24‐hr maximum rainfall for the upcoming season, using predictors identified through the Shared Reciprocal Nearest Neighbor approach. The model uses a generalized linear regression and a four‐parameter Beta distribution model for downscaling extremes using the predictors that were identified. A cross‐validation experiment for the last four decades in both Han‐River and Geum‐River watersheds, South Korea was performed to test the efficacy of the model. The leave‐one‐out cross‐validated seasonal precipitation forecast demonstrates a correlation that ranges from 0.69–0.78 to 0.68–0.76 for the Han‐River and Geum‐River watershed, respectively. Similarly, for the 24‐hr maximum rainfalls in the upcoming season, the cross‐validated correlations between the predicted and the observed values range from 0.67–0.73 to 0.50–0.63, for the two river basins. A discussion of the potential causes of the skill is offered.
Pervasive Desiccation of North American Lakes During the Late Quaternary
Authors: Liefert David T. , Shuman Bryan N.
Published: January 2020

Sedimentary records of lake‐level fluctuations have long provided unambiguous evidence of past hydrologic changes. Here, we synthesize geomorphic and sedimentological evidence of late‐Quaternary lake‐level changes across North America and show that currently moist regions were commonly drier than today. Many lakes across humid or snow‐dominated areas of North America were lower than today or totally desiccated for prolonged periods but rose to their current levels following climate changes in recent millennia. Maps of 173 records show that hydroclimates responded to deglacial dynamics and orbital changes but that regional hydrology changed even under the modest forcing and temperature variability of the past 8,000 years. Submerged paleoshorelines, ubiquitous across humid regions, reveal that North America's ecosystems and critical zone existed in a drier‐than‐modern state for much of the Quaternary and that continental moisture gradients often differed from today. The hydrologic changes underscore the climatic risk to many societally critical water supplies.
Magnetostratigraphy and Palaeoclimatic Significance of the Late Pliocene Red Clay‐Quaternary Loess Sequence in the Lanzhou Basin, Western Chinese Loess Plateau
Authors: Guo Benhong , Peng Tingjiang , Yu Hao , Hui Zhengchuang , Ma Zhenhua , Li Xiaomiao , Feng Zhantao , Liu Jia , Liu Shanpin , Zhang Jun , Ye Xiyan , Song Chunhui , Li Jijun
Published: January 2020

The history of red clay‐loess accumulation in the Chinese Loess Plateau (CLP) is the key to understanding the aridification history of the Asian interior and the uplift of the Tibetan Plateau. Here we present high‐resolution magnetostratigraphy and grain‐size records of a 265.7‐m‐long drill core of the red clay‐loess sequence at Gaolanshan in the Lanzhou Basin from the western CLP. Our results, combined with the loess‐paleosol stratigraphy and regional stratigraphic correlation, indicate that the most complete and continuous red clay‐loess sequence since ~3 Ma was first found in the western CLP, which is ~0.8 Myr older than the previously investigated Quaternary loess in the Lanzhou region, and the age of the oldest Lanzhou loess‐paleosol sequence is ~2.8 Ma. Consequently, the major enhancement of the aridification at 2.8 Ma in the Asian interior was primarily controlled by the uplift of the Tibetan Plateau and global cooling.
Influence of Barotropic Tidal Currents on Transport and Accumulation of Floating Microplastics in the Global Open Ocean
Authors: Sterl Miriam F. , Delandmeter Philippe , van Sebille Erik
Published: January 2020

Floating plastic debris is an increasing source of pollution in the world's oceans. Numerical simulations using models of ocean currents give insight into the transport and distribution of microplastics in the oceans, but most simulations do not account for the oscillating flow caused by global barotropic tides. Here, we investigate the influence of barotropic tidal currents on the transport and accumulation of floating microplastics, by numerically simulating the advection of virtual plastic particles released all over the world's oceans and tracking these for 13 years. We use geostrophic and surface Ekman currents from GlobCurrent and the currents caused by the four main tidal constituents (M
, S
, K
, and O
) from the FES model. We analyze the differences between the simulations with and without the barotropic tidal currents included, focusing on the open ocean. In each of the simulations, we see that microplastic accumulates in regions in the subtropical gyres, which is in agreement with observations. The formation and location of these accumulation regions remain unaffected by the barotropic tidal currents. However, there are a number of coastal regions where we see differences when the barotropic tidal currents are included. Due to uncertainties of the model in coastal regions, further investigation is required in order to draw conclusions in these areas. Our results suggest that, in the global open ocean, barotropic tidal currents have little impact on the transport and accumulation of floating microplastic and can thus be neglected in simulations aimed at studying microplastic transport in the open ocean.
Virulent coliphages in 1-year-old children fecal samples are fewer, but more infectious than temperate coliphages
Authors: Mathieu Aurélie , Dion Moïra , Deng Ling , Tremblay Denise , Moncaut Elisabeth , Shah Shiraz A. , Stokholm Jakob , Krogfelt Karen A. , Schjørring Susanne , Bisgaard Hans , Nielsen Dennis S. , Moineau Sylvain , Petit Marie-Agnès
Published: January 2020

Bacteriophages constitute an important part of the human gut microbiota, but their impact on this community is largely unknown. Here, we cultivate temperate phages produced by 900 E. coli strains isolated from 648 fecal samples from 1-year-old children and obtain coliphages directly from the viral fraction of the same fecal samples. We find that 63% of strains hosted phages, while 24% of the viromes contain phages targeting E. coli. 150 of these phages, half recovered from strain supernatants, half from virome (73% temperate and 27% virulent) were tested for their host range on 75 E. coli strains isolated from the same cohort. Temperate phages barely infected the gut strains, whereas virulent phages killed up to 68% of them. We conclude that in fecal samples from children, temperate coliphages dominate, while virulent ones have greater infectivity and broader host range, likely playing a role in gut microbiota dynamics.
Ultralow-noise photonic microwave synthesis using a soliton microcomb-based transfer oscillator
Authors: Lucas Erwan , Brochard Pierre , Bouchand Romain , Schilt Stéphane , Südmeyer Thomas , Kippenberg Tobias J.
Published: January 2020

The synthesis of ultralow-noise microwaves is of both scientific and technological relevance for timing, metrology, communications and radio-astronomy. Today, the lowest reported phase noise signals are obtained via optical frequency-division using mode-locked laser frequency combs. Nonetheless, this technique ideally requires high repetition rates and tight comb stabilisation. Here, a microresonator-based Kerr frequency comb (soliton microcomb) with a 14 GHz repetition rate is generated with an ultra-stable pump laser and used to derive an ultralow-noise microwave reference signal, with an absolute phase noise level below  −60 dBc/Hz at 1 Hz offset frequency and  −135 dBc/Hz at 10 kHz. This is achieved using a transfer oscillator approach, where the free-running microcomb noise (which is carefully studied and minimised) is cancelled via a combination of electronic division and mixing. Although this proof-of-principle uses an auxiliary comb for detecting the microcomb’s offset frequency, we highlight the prospects of this method with future self-referenced integrated microcombs and electro-optic combs, that would allow for ultralow-noise microwave and sub-terahertz signal generators.
Lamellar architectures in stiff biomaterials may not always be templates for enhancing toughness in composites
Authors: Monn Michael A. , Vijaykumar Kaushik , Kochiyama Sayaka , Kesari Haneesh
Published: January 2020

The layered architecture of stiff biological materials often endows them with surprisingly high fracture toughness in spite of their brittle ceramic constituents. Understanding the link between organic–inorganic layered architectures and toughness could help to identify new ways to improve the toughness of biomimetic engineering composites. We study the cylindrically layered architecture found in the spicules of the marine sponge Euplectella aspergillum. We cut micrometer-size notches in the spicules and measure their initiation toughness and average crack growth resistance using flexural tests. We find that while the spicule’s architecture provides toughness enhancements, these enhancements are relatively small compared to prototypically tough biological materials, like nacre. We investigate these modest toughness enhancements using computational fracture mechanics simulations.
Spatial adiabatic passage of massive quantum particles in an optical Lieb lattice
Authors: Taie Shintaro , Ichinose Tomohiro , Ozawa Hideki , Takahashi Yoshiro
Published: January 2020

Quantum interference lies at the heart of quantum mechanics. By utilizing destructive interference, it is possible to transfer a physical object between two states without populating an intermediate state which is necessary to connect the initial and final states. A famous application is a technique of stimulated Raman adiabatic passage, where atomic internal states can be transfered with high efficiency regardless of lossy intermediate states. One interesting situation is a case where the initial and final states are spatially well separated. Quantum mechanics allows a particle to move without practical possibility of being found at the intermediate area. Here we demonstrate this spatial adiabatic passage with ultracold atoms in an optical lattice. Key to this is the existence of dark eigenstates forming a flat energy band, with effective transfer between two sublattices being observed. This work sheds light on a study of coherent control of trapped cold atoms.
Rapid and deep-scale ubiquitylation profiling for biology and translational research
Authors: Udeshi Namrata D. , Mani Deepak C. , Satpathy Shankha , Fereshetian Shaunt , Gasser Jessica A. , Svinkina Tanya , Olive Meagan E. , Ebert Benjamin L. , Mertins Philipp , Carr Steven A.
Published: January 2020

Protein ubiquitylation is involved in a plethora of cellular processes. While antibodies directed at ubiquitin remnants (K-ɛ-GG) have improved the ability to monitor ubiquitylation using mass spectrometry, methods for highly multiplexed measurement of ubiquitylation in tissues and primary cells using sub-milligram amounts of sample remains a challenge. Here, we present a highly sensitive, rapid and multiplexed protocol termed UbiFast for quantifying ~10,000 ubiquitylation sites from as little as 500 μg peptide per sample from cells or tissue in a TMT10plex in ca. 5 h. High-field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) is used to improve quantitative accuracy for posttranslational modification analysis. We use the approach to rediscover substrates of the E3 ligase targeting drug lenalidomide and to identify proteins modulated by ubiquitylation in models of basal and luminal human breast cancer. The sensitivity and speed of the UbiFast method makes it suitable for large-scale studies in primary tissue samples.
Impact of commonly used drugs on the composition and metabolic function of the gut microbiota
Authors: Vich Vila Arnau , Collij Valerie , Sanna Serena , Sinha Trishla , Imhann Floris , Bourgonje Arno R. , Mujagic Zlatan , Jonkers Daisy M. A. E. , Masclee Ad A. M. , Fu Jingyuan , Kurilshikov Alexander , Wijmenga Cisca , Zhernakova Alexandra , Weersma Rinse K.
Published: January 2020

The human gut microbiota has now been associated with drug responses and efficacy, while chemical compounds present in these drugs can also impact the gut bacteria. However, drug–microbe interactions are still understudied in the clinical context, where polypharmacy and comorbidities co-occur. Here, we report relations between commonly used drugs and the gut microbiome. We performed metagenomics sequencing of faecal samples from a population cohort and two gastrointestinal disease cohorts. Differences between users and non-users were analysed per cohort, followed by a meta-analysis. While 19 of 41 drugs are found to be associated with microbial features, when controlling for the use of multiple medications, proton-pump inhibitors, metformin, antibiotics and laxatives show the strongest associations with the microbiome. We here provide evidence for extensive changes in taxonomy, metabolic potential and resistome in relation to commonly used drugs. This paves the way for future studies and has implications for current microbiome studies by demonstrating the need to correct for multiple drug use.