bluuebunny/crossref_metadata_2025 huggingface dataset:
Aplikasi Identifikasi Suara Hewan Menggunakan Metode Mel-Frequency Cepstral Coefficients (MFCC)
Authors: Astuti Dwi
Published: January 2020

Pengenalan suara berada dibawah bidang komputasi linguistik. Hal ini mencakup identifikasi, pengakuan, dan terjemahan ucapan yang terdeteksi ke dalam teks oleh komputer. Penelitian ini menggunakan handphone dan sistem yang dirancang menggunakan suara. Tujuan utama dari penelitian ini adalah menggunakan teknik pengenalan suara untuk mendeteksi, mengidentifikasi dan menerjemahkan suara binatang. Sistem ini terdiri dari dua tahap yaitu pelatihan dan pengujian. Pelatihan melibatkan pengajaran sistem dengan membangun kamus, model akustik untuk setiap kata yang perlu dikenali oleh sistem (analisis offline). Tahap pengujian menggunakan model akustik untuk mengenali kata-kata terisolasi menggunakan algoritma klasifikasi. Aplikasi penyimpanan audio untuk mengidentifikasi berbagai suara binatang dapat dilakukan dengan lebih akurat dimasa depan.
A Prototype Detects Regional Songs as Educational Media Using the Google Speech API
Authors: Zain Isnanda Muhammad
Published: January 2020

Salah satu upaya melestarikan budaya Indonesia dengan mengenalkan lagu-lagu daerah kepada anak-anak sejak dini. Telah banyak media edukasi untuk mengenalkan lau-lagu daerah, dimulai dari mainan bersuara sampai game offline atau online. Penelitian ini bertujuan mengenalkan kumpulan lagu-lagu yang diambil dari kekayaan pulau-pulau di Indonesia (lagu daerah). Dengan sistem ini pengguna dapat menikmati lagu-lagu daerah sekaligus menambah pengetahuan dengan menebak nada yang didengar dengan judul lagu yang sesuai. Ketika pengguna menyanyikan salah satu lagu daerah sistem akan melanjutkan lagu tersebut dan memberikan informasi mengenai judul lagu dan lirik dari lagu tersebut. Sehingga, sistem ini dapat memberikan pengetahuan bukan hanya  mengenalkan lagu daerah bahkan penguna dapat mengetahui lirik dari lagu tersebut bertujuan agar pengguna dapat menikmati lagu sambil bernyanyi.
Implementasi Naive Bayes
Authors: Kawani Gigih Putra
Published: January 2020

Perkembangan sektor industri yang semakin pesat dalam memenuhi kebutuhan hidup setiap harinya membutuhkan bahan kimia sebagai bahan utama dalam proses suatu produksi. Tidak sedikit dari bahan kimia tersebut mengandung zat berbahaya dan beracun yang dapat menimbulkan efek yang sangat membahayakan bagi lingkungan dan manusia. Oleh karena itu, perlu adanya penanganan khusus untuk mengurangi dampak buruk yang terjadi melalui proses pengelolaan limbah B3. Salah satu pendekatan yang dapat dilakukan untuk menganalisa kemasan limbah B3 adalah dengan metode klasifikasi. Dalam hal ini bertujuan untuk mengklasifikasi wadah limbah B3 untuk mengurangi resiko jika terjadi tumpahan dan bocoran. Adapun algoritma yang digunakan adalah naive Bayes. Dari 41 data limbah B3, 38 data diantaranya sudah terklasifikasi dengan benar dan 3 data tidak terklasifikasi dengan benar. Algoritma naive bayes mamanfaatkan data training dan data testing untuk mengklasifikasi wadah limbah tersebut. Dari hasil klasifikasi wadah limbah B3 diperoleh persentase 75% untuk akurasi prediksi wadah limbah B3.

Keywords: Limbah B3, Klasifikasi, Naive Bayes
IDENTIFIKASI CITRA TANDA TANGAN BERDASARKAN GRID ENTROPY DAN PCA MENGGUNAKAN MULTI LAYER PERCEPTRON
Authors: Nafan Muhammad Zidny , Anggoro Agung Wisnu , Usada Elisa
Published: January 2020

Tanda tangan merupakan tanda yang bertujuan sebagai lambang dari nama seseorang yang dituliskan menggunakan tangan orang itu sendiri sebagai penanda pribadi. Penggunaan tanda tangan tidak luput dalam kehidupan sehari-hari, penting untuk mengenal bentuk tanda tangan seseorang untuk melakukan verifikasi apakah tnada tangan tersebut milik orang yang bersangkutan atau orang lain. Pada penelitian ini penulis membuat penelitian mengenai identifikasi tanda tangan dengan menggunakan Grid Entropy dan Principal Component Analysis sebagai ekstraksi ciri. Model pembelajaran dataset menggunakan Multi Layer Perceptron dan Cross Validation menggunakan nilai parameter yang berbeda pada hidden layer dan node dalam Multi Layer Perceptron. Hasil pengujian terbaik didapatkan dari pembelajaran dataset menggunakan 2 hidden layer dengan node sebanyak 40 node di setiap hidden layer, dari skenario tersebut didapatkan akurasi sebesar 87,22%.
Klasifikasi Analisis Sentimen Pada Gambar Meme Politik Dengan Library Tesseract Dan Algoritme Support vector machine
Authors: Sanjaya Eko , Prasetiadi Agi , SAPUTRA WAHYU ANDI
Published: January 2020

Meme merupakan penyebaran informasi dalam bentuk gambar. Berdasarkan data yang diperoleh, pengembangan meme mulai meningkat menjelang pemilu 2019. Informasi yang diperoleh dari meme politik beragam. Salah satunya memberikan dukungan untuk suatu partai atau tokoh politik atau digunakan untuk mengkritik / mencaci-maki partai politik atau tokoh. Sehingga diperlukan suatu sistem yang dapat mengklasifikasikan meme berdasarkan kelas Penelitian ini bertujuan untuk menciptakan sistem yang dapat mengklasifikasikan meme politik berdasarkan kelas. Algoritma yang akan digunakan dalam mengklasifikasikan adalah Support vector macine (SVM) dengan ekstraksi fitur TF-IDF. Library yang akan digunakan dalam optical character recognition (OCR) adalah Tesseract. Berdasarkan hasil pengujian diketahui bahwa akurasi yang dihasilkan oleh SVM linier lebih baik daripada SVM non-linear. Akurasi terbaik dalam SVM linear dengan kombinasi TF-IDF adalah 75.71%.
Use of potentially inappropriate medication and polypharmacy in older adults: a repeated cross-sectional study
Authors: Thorell Kristine , Midlöv Patrik , Fastbom Johan , Halling Anders
Published: January 2020

Background: With age, the number of chronic conditions increases along with the use of medications. For several years, polypharmacy has been found to be on the increase in western societies. Polypharmacy is associated with an increased risk of adverse drug events (ADE). Medications called potentially inappropriate medications (PIM) have also been found to increase the risk of ADEs in an older population. In this study, which we conducted during a national information campaign to reduce PIM, we analysed the prevalence of PIM in an older adult population and in different strata of the variables age, gender, number of chronic conditions and polypharmacy and how that prevalence changed over time. Methods: This is a registry-based repeated cross-sectional study including two cohorts. Individuals aged 75 or older listed at a primary care centre in Blekinge on the 31st March 2011 (cohort 1, 15 361 individuals) or on the 31st December 2013 (cohort 2, 15 945 individuals) were included in the respective cohorts. Using a chi2 test, the two cohorts were compared on the variables age, gender, number of chronic conditions and polypharmacy. Use of five or more medications at the same time was the definition for polypharmacy. Results: Use of PIM decreased from 10.60% to 7.04% (p-value <0.001) between 2011 and 2013, while prevalence of five to seven chronic conditions increased from 20.55% to 23.66% (p-value <0.001). Use of PIM decreased in all strata of the variables age, gender number of chronic conditions and polypharmacy. Except for age 80-84 and males, where it increased, prevalence of polypharmacy was stable in all strata of the variables. Conclusions: Use of potentially inappropriate medications had decreased in all variables between 2011 and 2013; this shows the possibility to reduce PIM with a focused effort. Polypharmacy does not increase significantly compared to the rest of the population.
RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio
Authors: Saddala Madhu Sudhana , Lennikov Anton , Bouras Adam , Huang Hu
Published: January 2020

Background Retinal degenerative diseases affect millions of people and represent the leading cause of vision loss around the world. Retinal degeneration has been attributed to a wide variety of causes, such as disruption of genes involved in phototransduction, biosynthesis, folding of the rhodopsin molecule, and the structural support of the retina. The molecular pathogenesis of the biological events in retinal degeneration is unclear; however, the molecular basis of the retinal pathological defect can be potentially determined by gene-expression profiling of the whole retina. In the present study, we analyzed the differential gene expression profile of the retina from a wild-type zebrafish and phosphodiesterase 6c (pde6c) mutant. Results The datasets were downloaded from the Sequence Read Archive (SRA), and adaptors and unbiased bases were removed, and sequences were checked to ensure the quality. The reads were further aligned to the reference genome of zebrafish, and the gene expression was calculated. The differentially expressed genes (DEGs) were filtered based on the false discovery rate (FDR) (±4) and p-values (p < 0.001). We performed gene annotation (molecular function [MF], biological process [BP], cellular component [CC]), and determined the functional pathways Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway for the DEGs. Our result showed 216 upregulated and 3,527 downregulated genes between normal and pde6c mutant zebrafish. These DEGs are involved in various KEGG pathways, such as the phototransduction (12 genes), mRNA surveillance (17 genes), phagosome (25 genes), glycolysis/gluconeogenesis (15 genes), adrenergic signaling in cardiomyocytes (29 genes), ribosome (20 genes), the citrate cycle (TCA cycle; 8 genes), insulin signaling (24 genes), oxidative phosphorylation (20 genes), and RNA transport (22 genes) pathways. Many more of all the pathway genes were downregulated, while fewer were upregulated in the retina of mutant zebrafish. Conclusions Our data strongly indicate that, among these genes, the above-mentioned pathways’ genes as well as calcium-binding, neural damage, peptidase, immunological, and apoptosis proteins are mostly involved in the retinal and neural degeneration that cause abnormalities in photoreceptors or retinal pigment epithelium (RPE) cells.
Maternal coffee intake and the risk of bleeding in early pregnancy: A cross-sectional analysis
Authors: Choi Hansol , Koo Seul , Park Hyun-Young
Published: January 2020

Background: Caffeine can easily cross the placenta, and maternal caffeine intake, thus, has an effect on fetal growth. However, it is still unclear whether coffee consumption is an independent risk factor for bleeding in early pregnancy. The objective of this study was to examine the association between pre-pregnancy coffee consumption patterns and the risk of bleeding in early pregnancy. Methods: A cross-sectional analysis was conducted among 3,510 pregnant women from the Korean Pregnancy Outcome Study who underwent baseline examination and for whom the results of the pregnancy were available. Coffee consumption patterns before pregnancy were examined using a questionnaire. The participants were classified according to the frequency of coffee consumption into seldom (<1 cup/week), light (<1 cup/day), moderate (1 cup/day), and heavy coffee drinker (≥2 cups/day) groups. Bleeding in early pregnancy was defined as the occurrence of vaginal bleeding in the first 20 weeks of pregnancy. Multiple logistic regression models were applied to examine the association between pre-pregnancy coffee consumption and the risk of bleeding in early pregnancy, after adjusting for age, body mass index (BMI), systolic blood pressure, cigarette smoking and alcohol consumption behavior, previous and current physical activity levels, stress levels, history of depression, antenatal depressive symptoms during the first trimester, type of emesis, parity, and the number of livebirths, stillbirths, miscarriages, and abortions. Results: Women who were light, moderate, and heavy coffee drinkers before pregnancy had adjusted ORs of 1.086, 1.225, and 1.358, respectively, for bleeding in early pregnancy. In a fully adjusted model, heavy coffee drinkers showed a significantly higher risk of bleeding in early pregnancy, even in women aged 35 years and younger (OR 1.680) and in those with a normal body mass index (OR 1.389), who were at relatively low risk for pregnancy-related complications. Conclusions: Our results showed that heavy coffee drinking was independently associated with a higher risk of bleeding in early pregnancy among pregnant Korean women, suggesting that caffeine intake before conception and during pregnancy should be reduced. Our study highlights the need for nutritional interventions for healthy coffee drinking among pregnant women in Korea.
Correlation between clinical parameters of crown and gingival morphology of anterior teeth and periodontal biotypes
Authors: Yin Xiao-jie , Wei Bang-yan , Ke Xiu-ping , Zhang Ting , Jiang Meng-yang , Luo Xia-yan , Sun Hui Qiang
Published: January 2020

Background : In this study, we conducted a quantitative analysis of the clinical parameters of crown and gingival morphology (CGM) of the maxillary anterior teeth (MAT). We also analyzed the correlation of these parameters with periodontal biotype (PB), with a view to providing objective standards for PB diagnosis. Methods : The three-dimensional (3D) maxillary digital models of 56 individuals were obtained using an intra-oral scanner. The following parameters were measured with the SpaceClaim software: gingival angle (GA), papilla width (PW), papilla height (PH), crown length (CL), crown width (CW), crown width/crown length ratio (CW/CL), bucco-lingual width of the crown (BLW), contact surface width (CSW), and contact surface height/crown length ratio (CS/CL). The PB were determined based on the transparency of the periodontal probe through the gingival sulcus. Independent factors influencing PB were analyzed by logistic regression, and the optimal cutoff values for the independent influencing factors were analyzed using receiver operating characteristic curves (ROC curves). Results : There was no significant difference in the parameters of CGM of the MAT at the left and right sides. The thick biotype accounted for 69.6%, and the parameters of GA, PW, PH, CW, CW/CL and CS/CL were significantly correlated with PB ( P ≤ 0.2). GA (odds ratio (OR) = 1.206) and PW (OR = 5.048) were identified as independent predictive factors of PB, with areas under the ROC curve (AUC) of 0.807 and 0.881, respectively, and optimal cutoff values of 95.95° and 10.01 mm, respectively. Conclusion: The CGMs of the MAT at the left and right side are symmetrical. The thin biotype accounts for a small proportion, and GA and PW are independent influencing factors of PB. GA of 95.95° and PW of 10.01 mm are the optimal cutoff values for categorization of individuals as thick biotype. This indicates that when the GA and PW of the right maxillary central incisor are G ≥95.95° and ≥10.01 mm, respectively, there is a higher probability that these individuals will be categorized as thick biotype.
Molecular detection and phylogenetic analysis of Lumpy skin disease virus from outbreaks in Uganda 2017-2018
Authors: Ochwo Sylvester , VanderWaal Kimberly , Ndekezi Christian , Nkamwesiga Joseph , Munsey Anna , Witto Sarah Gift , Nantima Noelina , Mayanja Franklin , Okurut Anna Rose Ademun , Atuhaire David Kalenzi , Mwiine Frank Norbert
Published: January 2020

Background: Lumpy skin disease (LSD) is an infectious viral disease of cattle caused by a Capripox virus. LSD has substantial economic implications, with infection resulting in permanent damage to the skin of affected animals which lowers their commercial value. In Uganda, LSD is endemic and cases of the disease are frequently reported to government authorities. This study was undertaken to molecularly characterize lumpy skin disease virus (LSDV) strains that have been circulating in Uganda between 2017 and 2018. Secondly, the study aimed to determine the phylogenetic relatedness of Ugandan LSDV sequences with published sequences, available in GenBank. Results: A total of 7 blood samples and 16 skin nodule biopsies were screened for LSDV using PCR to confirm presence of LSDV nucleic acids. PCR positive samples were then characterized by amplifying the GPCR gene. These amplified genes were sequenced and phylogenetic trees were constructed. Out of the 23 samples analyzed, 15 were positive for LSDV by PCR (65.2%). The LSDV GPCR sequences analyzed contained the unique signatures of LSDV (A11, T12, T34, S99, and P199) which further confirmed their identity. Sequence comparison with vaccine strains revealed a 12bp deletion unique to Ugandan outbreak strains. Phylogenetic analysis indicated that the LSDV sequences from this study clustered closely with sequences from neighboring East African countries and with LSDV strains from recent outbreaks in Europe. It was noted that the sequence diversity amongst LSDV strains from Africa was higher than diversity from Eurasia. Conclusion: The LSDV strains circulating in Uganda were closely related with sequences from neighboring African countries and from Eurasia. Comparison of the GPCR gene showed that outbreak strains differed from vaccine strains. This information is necessary to understand LSDV molecular epidemiology and to contribute knowledge towards the development of control strategies by the Government of Uganda.
Prevalence and correlates of Alzheimer’s disease and related dementias in rural Uganda: cross-sectional, population-based study
Authors: MUBANGIZI VINCENT , Maling Samuel , Obua Celestino , Tsai Alexander C.
Published: January 2020

Background: There is a paucity of data on the prevalence and correlates of Alzheimer’s disease and related dementias in sub-Saharan Africa. The aim of the study was to estimate the prevalence and correlates of Alzheimer’s disease and related dementias in rural Uganda. Methods: We conducted a cross-sectional, population-based study in a rural region of southwestern Uganda. The Brief Community Screening Instrument for Dementia was administered to a multi-stage area probability sample of 400 people aged 60 years and over. Multivariable logistic regression was used to estimate correlates of probable dementia. Results: Overall, 80(20%) of the sample screened positive for dementia. On multivariable regression, we estimated the following correlates of probable dementia: age (adjusted odds ratio [AOR], 1.02 per year; 95% confidence interval [CI], 1.10-1.03, p˂0.001), having some education (AOR, 0.57; 95% CI, 0.41-0.81, p=0.001), exercise (AOR, 0.44; 95% CI, 0.27-0.72, p=0.001), and having a ventilated kitchen (AOR, 0.43; (95% CI, 0.24-0.77, p=0.001). Conclusions: In this population-based sample of older-age adults, nearly one-fifth screened positive for dementia. Key words: Alzheimer’s disease, dementia, Sub-Saharan Africa, Uganda
Mitochondrial DNA copy number in cervical exfoliated cells and risk of cervical cancer among HPV-positive women
Authors: Sun Wei , Qin Xueyun , Zhou Jing , Xu Mingjing , Lyu Zhangyan , Li Xin , Zhang Kai , Dai Min , Li Ni , Hang Dong
Published: January 2020

Background
Although human papillomavirus (HPV) infection has been recognized as the major cause of cervical cancer, only a minority of HPV-infected women develop this malignancy. An increasing amount of evidence suggests that alterations of mitochondrial DNA copy number (mtCN) may c ontribute to carcinogenesis. However, the relationship between mtCN and cervical cancer remains unknown.
Methods
In this case-control study, we included 591 cervical cancer cases and 373 cancer-free controls, all of whom were infected with high-risk HPV. Relative mtCN in cervical cancer exfoliated cells was measured by qRT-PCR assay s , and logistic regression analysis was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Interaction between mtCN and HPV types was assessed by using the Wald test in logistic regression models.
Results
HPV16, 18, 52, and 58 were the most common types in both case and control groups. Median mtCN in cases was significantly higher than that in controls ( P = 0.03). After adjustment for age and HPV types , the highest quartile of mtCN was associated with increased odds of having cervical cancer (OR = 1.77, 95% CI = 1.19, 2.62; P < 0.01), as compared to the lowest quartile. A dose-response effect of mtCN on cervical cancer was also observed ( P trend < 0.001). The interaction between mtCN and HPV types was statistically nonsignificant.
Conclusions
Increased mtCN in cervical exfoliated cells is associated with cervical cancer after HPV infection, suggesting a potential role of mtCN in cervical carcinogenesis.
Different effects of Wnt/β-catenin activation and PTH activation in adult and aged male mice metaphyseal fracture healing
Authors: Liu Daocheng , Qin Hao , Yang Jiazhi , Yang Lei , He Sihao , Chen Sixu , Bao Quanwei , Zhao Yufeng , zong zhaowen
Published: January 2020

Background: Fractures in older men are not uncommon and need to be healed as soon as possible to avoid related complications. Anti-osteoporotic drugs targeting Wnt/β-catenin and PTH (parathyroid hormone) to promote fracture healing have become an important direction in recent years.Objective: Observe whether there is a difference in adult and aged situations by activating two signal paths.Methods: A single cortical hole with a diameter of 0.6 mm was made in the femoral metaphysis of Catnblox(ex3) mice and wild-type mice. The fracture healing effects of CA(Wnt/β-catenin activation) and PTH (activated by PTH (1–34) injections) were assessed by X-ray and CT imaging on days 7, 14, and 21 after fracture. The mRNA levels of β-catenin, PTH1R(Parathyroid hormone 1 receptor), and RUNX2(Runt-related transcription factor 2) in the fracture defect area were detected using RT-PCR. Angiogenesis and osteoblasts were observed by immunohistochemistry and osteoclasts were observed by TRAP (Tartrate-resistant Acid Phosphatase).Result: Adult CA mice and adult PTH mice showed slightly better fracture healing than adult wild-type (WT) mice, but there was no statistical difference. Aged CA mice showed better promotion of angiogenesis and osteoblasts and better fracture healing than aged PTH mice.Conclusion: The application of Wnt/β-catenin signaling pathway drugs for fracture healing in elderly patients may bring better early effects than PTH signaling pathway drugs, but the long-term effects need to be observed.
The efficacy of Narrative Exposure Therapy for Children (KIDNET) as a Treatment for Traumatized Young Refugees versus Treatment as Usual: Study Protocol for a Multi-Center Randomized Controlled Trial (YOURTREAT)
Authors: Wilker Sarah , Catani Claudia , Wittmann Jasmin , Preusse Melissa , Schmidt Telja , May Theodor , Ertl Verena , Doering Bettina , Rosner Rita , Zindler Areej , Neuner Frank
Published: January 2020

Background: Germany hosts a large number of refugees from war-affected countries. The integration of refugees, in particular young refugees from the Middle East, is one of the major current social challenges in Germany. Mental disorders, first of all post-traumatic stress disorder (PTSD) that results from war experiences, are common among young refugees and interfere with quality of life as well as functional integration. Evidence regarding effective treatment options for this population is scarce. In this trial, we aim to evaluate the pragmatic, short-term psychotherapy Narrative Exposure Therapy for Children (KIDNET) for the treatment of young refugees in Germany.
Methods: In a rater-blinded multi-center randomized-controlled trial, KIDNET is compared to treatment as usual (TAU) within the general health care system. A total number of 80 young refugees who fulfill the diagnostic criteria of PTSD will be randomized to either KIDNET or TAU. Diagnostic interviews will take place at baseline before treatment as well as six and 12 months thereafter. They will assess exposure to traumatic events, PTSD and comorbid symptoms, as well as parameters of integration.
Discussion: The results of this study will provide evidence regarding effective treatment options for young refugees in Germany, a population that has been understudied and received only limited access to mental health care so far. Next to the effects of treatment on mental health outcomes, integration parameters will be investigated. Therefore, this study will provide broad insights into treatment options for young refugees and their potential implications on successful integration.
Trial registration: German Clinical Trials Register (Deutsches Register Klinischer Studien; DRKS), registered on May 15 th , 2019. The trial registration number is DRKS00017222 (www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00017222)
Usefulness of a radial applanation tonometry device in blood pressure related clinical decision making by anesthesiologists
Authors: Zhou Xiaoshuang , Liu Bin , Lan Haidan , Liu Jin , Li Xiao , Chen Guo
Published: January 2020

Purpose: Radial artery tonometry (AT) can continuously measure arterial blood pressure (ABP) noninvasively. This study aimed to evaluate AT for continuous ABP monitoring during anesthesia and compared AT to invasive (IBP) and non-invasive (NIBP) ABP measurements at clinical decision-making moments. Methods: 243 patients undergoing elective surgery were prospectively included in the study and AT was applied on the right or left arm while IBP and NIBP were recorded simultaneously. At moments when the IBP signal required a clinical decision by the anesthesiologist for situations of hyper- or hypotension, comparison was made whether AT and NIPB signals would require a clinical decision as well. Agreement/discrepancy of clinical decision-making was analyzed, additionally bias, precision, and percentage error of AT was compared to IBP at these moments. Results: 513 clinical decision moments were recorded. Decision moments based on AT signal did not differ significantly from decision moments based on IBP (1 vs. 1; IQR, 1 – 2 vs. 0 – 3, P = 0.06), while NIBP based decision moments showed significant differences (0 vs. 1; IQR, 0 – 2 vs. 0 – 3, P＜0.001). Subgroup analysis of patients divided by age, BMI and surgery time also showed no significant differences between IBP and AT. Conclusions: ABP measurement using AT is feasible and safe. AT provides relevant and efficient information to anesthesiologists; at moments when IBP called for action, AT called for action as well, but not NIBP. AT also showed clinically satisfactory agreement with IBP at moments of hypo- and hypertension.
A Comprehensive Strategic Analysis of the Environmental Scanning of Iranian Public Hospitals: A Prospective Approach
Authors: pourmohammadi Kimia , Bastani Peivand , Shojaei Payam , Hatam Nahid , Salehi Asiyeh
Published: January 2020

Objectives: This study was conducted to interpret the micro and macro environmental issues of public hospitals in order to equip hospital managers to plan and perform proactively and could deal more better with uncertain future. Results: semi-structured in-depth interview and a researcher-made questionnaire were used to determine macro and micro level issues based on PESTLE (Political, Economic, Social, Technological, Legal and Environmental) and Douglas West framework in order to determine the effectiveness and feasibility of factors The key issues at micro level environment were related to prescription and overuse of pharmaceuticals, inequality in distribution of healthcare services and high demands for luxurious services. At macro level: changes in disease patterns, inappropriate hospital budgeting, economic sanctions, government corruption and centralization had a great impact on public hospitals in Iran. following the safety guidelines laid down by the government and better management of bed distribution in order to decrease waiting times at micro level and improve strategic policies in order to have quality-based payment system, enhance the efficiency and effectiveness of services and strategic purchasing are the most important ways at macro level. At this time, the considerable impact of economic sanctions on hospital financial resources should not be ignored.
New insights from the biogas microbiome by comprehensive genome-resolved metagenomics of nearly 1600 species originating from multiple anaerobic digesters
Authors: Campanaro Stefano , Treu Laura , Rodriguez-Rojas Luis M , Kovalovszki Adam , Ziels Ryan M , Maus Irena , Zhu Xinyu , Kougias Panagiotis G. , Basile Arianna , Luo Gang , Schlüter Andreas , Konstantinidis Konstantinos T. , Angelidaki Irini
Published: January 2020

BackgroundMicroorganisms in biogas reactors are essential for degradation of organic matter and methane production. However, a comprehensive genome-centric comparison, including relevant metadata for each sample, is still needed to identify the globally distributed biogas community members and serve as a reliable repository.ResultsHere, 134 publicly available metagenomes derived from different biogas reactors were used to recover 1,635 metagenome-assembled genomes (MAGs) representing different biogas bacterial and archaeal species. All genomes were estimated to be >50% complete and nearly half ≥90% complete with ≤5% contamination. In most samples, specialized microbial communities were established, while only a few taxa were widespread among the different reactor systems. Metabolic reconstruction of the MAGs enabled the prediction of functional traits related to biomass degradation and methane production from waste biomass. An extensive evaluation of the replication index provided an estimation of the growth dynamics for microbes involved in different steps of the food chain. ConclusionsThe outcome of this study highlights a high flexibility of the biogas microbiome, allowing it to modify its composition and to adapt to the environmental conditions, including temperatures and a wide range of substrates. Our findings enhance our mechanistic understanding of the AD microbiome and substantially extend the existing repository of genomes. The established database represents a relevant resource for future studies related to this engineered ecosystem.
New nomograms based on treatment outcome and prognostic factors for patients with spinal diffuse large B-cell lymphoma: A population‐based study
Authors: Wang Ben , Chen Lijie , Chen Boda , Xie Chenglong , Shao Zhenxuan , Zhang Xiaolei , Chen Jiaoxiang , Wang Xiangyang
Published: January 2020

Background: Spinal diffuse large B-cell lymphoma (DLBCL) is a rare and malignant tumor, while few studies researched the prognostic factors. The prognostic factors which impacts on spinal DLBCL are not clear. Although chemotherapy was recognized as an optimal treatment method, but the curative effect of radiotherapy and surgery were controversial.Methods: The records of patients with spinal DLBCL were selected from the SEER database from 1991 to 2016. The incidence obtained by database was analyzed by Joinpoint Regression Program. The optimal cut-off values of age and year of diagnosis were identified by X-tail program. Univariate and multivariate survival analysis were calculated to identify independent prognostic factors. Prognostic factors were included to predict the survival possibility compared with 5 years of overall (OS) and cancer-specific survival (CSS) via the new nomograms. Results: A total of 917 patients were enrolled. Age, year of diagnosis and chemotherapy were demonstrated as independent prognostic factors for CSS and OS, and primary site was another independent prognostic factor for CSS. However, radiotherapy and surgery might be ineffective in survival. All factors were included to generate the nomograms for CSS and OS. The concordance indices (C-index) for internal validation of OS and CSS prediction were 0.697 (95%CI: 0.662-0.732) and 0.709 (95%CI: 0.692- 0.727) respectively.Conclusions: Age and year of diagnosis are closely associated with the prognosis of spinal DLBCL, and chemotherapy is an ideal treatment modality. The new nomogram is a favourable tool to evaluate the survival possibility, and is benefit for the oncologist to make clinical decisions.
Outcome of intravitreal bevacizumab injection without pre and postoperative antibiotics
Authors: Shrestha Ruchi , Karki Pratap , Joshi Sagun Narayan
Published: January 2020

Backgound Intravitreal injections are the most common treatment modality for several retinal pathologies. Despite endophthalmitis being the most feared complication, antibioprophylaxis remains controversial in intravitreal injections. Methods This was a retrospective study done for a period of 2 years from 1st January 2017 to 31st December 2018 in BPKLCOS among patients receiving intravitreal bevacizumab. The intravitreal injection was given by a single surgeon. It included 503 eyes which received intravitreal bevacizumab over a period of 2 years without pre and postoperative antibiotics. Results Out of 503 eyes studied over a period of 2 years without antibiotic prophylaxis the rate of endophthalmitis was 0.0019% which is very low compared to the other studies with rate of endophthalmitis between 0.019-0.09%. Conclusion The rate of endophthalmitis doesn’t increase after giving intravitreal injections without the use of preoperative/postoperative prophylactic antibiotics. Intravitreal injection can be given safely without pre-operative and post-operative antibiotics. Trial Registration not applicable as it is a retrospective study.
Exploring the Consistency of Adults’ Food Choice motives with Sustainable Diet Components: a Qualitative Study
Authors: Roudsari Arezoo Haghighian , Vedadhir Abouali , Shokouhi Maryam , Bonab Ali Milani
Published: January 2020

Background Todays, due to the impact of human food choices on increasing greenhouse gas emissions, water consumption and environmental degradation, there is a new thinking about changing the pattern of food production and consumption, including sustainable food and nutrition system related to consumption. This study aimed to explore the dimensions of a sustainable diet among the determinants of people's food choices. Methods This qualitative study was carried out using an in-depth interview with 33 individuals aged 30-64 years old living in different areas of Tehran. Data gathering, data analysis and theoretical conceptualization were performed simultaneously and from the beginning of the research, and for managing and organizing the data, the MAXQDA 10 software was used. Results In this paper, the findings are categorized according to the key components of a sustainable diet in five themes: "Health and Nutrition", "Food and Agriculture Security", "Environment and Ecosystems", "Markets, food trade and production chains", "social, cultural, and policy factors" were categorized. Meanwhile, the components of the "Health and Nutrition" domain had the highest contribution and the components of the two domains "food and agriculture" and "environment and ecosystems" had the lowest role among the statements of the participants in this study. Conclusion considering to the low importance of the dimensions of a sustainable diet in food choices of the community, promoting the individual awareness of sustainable diet components, clarifying the importance of food choices in creating environmental impacts and leading the national macro policies in the field food and nutrition toward sustainable diet goals are essential.
Economic Burden of Cardiovascular Diseases Before and After the Iran’s Health Transformation Plan: A Cross-Sectional Study on Referral Hospital in the North-West of Iran
Authors: Alipour Vahid , Zandian Hamed , Yazdi-Feyzabadi Vahid , Avesta Leili , Moghadam Telma Zahirian
Published: January 2020

Background Different countries have set different policies to control and decrease the costs of Cardiovascular Diseases(CVDs). Iran aiming reducing the economic burden of different disease by a recent reform from named as health transformation plan(HTP). This study aimed to examine economic burden of CVDs before and after of HTP, Methods This cross-sectional study was conducted on 600 patients with CVDs, who were randomly selected from a specialized cardiovascular hospital in the north-west of Iran. Direct and indirect costs of CVDs were calculated using cost of illness and human capital approaches. Data were collected using a researcher-made checklist obtained from several sources including structured interviews, the Statistical Center of Iran, Iran's Ministry of Cooperatives, Labor, and Social Welfare, central bank of the Iran, and the data of global burden of disease obtained from the Institute for Health Metrics and Evaluation to estimate direct and mortality costs. All costs were calculated in Iranian Rials(IRR). Results Total costs of CVDs were about 5571 and 6700 billion IRR before and after the HTP, respectively. More than 62% of the total costs of CVDs accounted for premature death before (64.89%) and after(62.01%) the HTP. The total hospitalization costs of CVDs was significantly increased after the HTP (p=0.038). In both times, surgical services and visiting had the highest and lowest share of hospitalization costs, respectively. The OOP expenditure decreased significantly and reached from 54.2% to 36.7%. All hospitalization costs, except patients' OOP expenditure, were significantly increased after the HTP about 1.3 times. Direct non-medical costs reached from 2.4 to 3.3 billion before and after the HTP, respectively. Conclusion The economic burden of CVDs after the HTP increased in the north-west of Iran due to the increase of all direct and indirect costs, except the OOP expenditure. Non-allocation of defined resources, which coincided with the international and national political and economic challenges in Iran, led to unsustainable resources of the HTP. So, no results of this study can be attributed solely to the HTP. Therefore, studies that are more detailed should be carried out on the reasons for the significant increase in CVDs costs in the region.
Additional effect of drinking water endocrine-disrupting compound exposure on fetal growth compared to the effect of active tobacco exposure during pregnancy
Authors: CARLES camille , ALBOUY-LLATY Marion , DUPUIS Antoine , RABOUAN Sylvie , MIGEOT Virginie
Published: January 2020

Background Active tobacco exposure during pregnancy is known to be an important determinant of fetal growth. Nitrates and atrazine metabolites in drinking water may affect fetal growth as a mixture of endocrine disruptors (ED). Our aim was to determine whether ED have an additional effect on fetal growth compared to the known and observed effect of active tobacco exposure during pregnancy. Methods A historic cohort study was carried out with a sample stratified with regard to maternity ward, drinking water exposure and year of birth. The women included were living in Deux-Sèvres, had given birth between 2005 and 2010 in three selected maternity wards, and ultrasound data from pregnancy were available in their obstetrical records. Mixed linear models were used to analyze fetal weight evolution from second trimester of pregnancy to time of birth according to drinking water exposure to atrazine metabolite and nitrate mixture and active tobacco exposure. Results We included 558 mother-neonate couples, of whom 8.5% were exposed to high doses of mixture and 20.5% to active tobacco smoking. There was no significant difference in fetal weight evolution according to drinking water mixture exposure (0.97 g; 95% CI [-3.01;4.94]) and when comparing nested models with and without drinking water mixture exposure, the likelihood ratio (LR) test was not significant (LR khi²=6.6, p=0.252). Conclusion We could not show a supplementary effect of mixture exposure on fetal growth as compared to active tobacco exposure. Further research is needed, using more precise methods to estimate ED exposure.
After Action Review Qualitative research on Yellow Fever outbreak Coordination, Surveillance & Reponses in Wolaita Zone of SNNPR Region, Ethiopia
Authors: Tufa Yonas Assefa , Fufa Yaregal , Gemechu Diriba , Abebe Melaku , Habebe Shambel , Yohannes Niguse , Mekonen Adamu Tayachew , Kinde Solomon , Belay Desalegn , Alemayehu Senait , Anebo Wadu Marshalo , Nasir Mohammed , W/Mariam Belete , Melese Mesfin , Girmay Abiy , Tilaye Tesfaye , Regasa Feyisa , Endris Abduilhafiz Assen , Assefa Zewdu , Doda Zerihun
Published: January 2020

Background: Coordinating outbreak investigations requires effective interagency communication. Important tasks include making the initial notifications, establishing roles and responsibilities for each jurisdiction, providing updates on the progress of the investigations, revising priorities for the investigation, and establishing the next steps. The major goal of surveillance activities is to identify and eliminate preventable causes of morbidity and mortality. Outbreak response basically entails preparedness which helps to establish arrangements in advance to enable timely, effective and appropriate responses to specific potential hazardous events or emerging disaster situations that might threaten society/environment Objective: To review lessons learned from the October 2018 Wolayta Zone yellow fever outbreak management in SNNPR, Ethiopia. Methods: Qualitative research approach, with Thematic Analysis. Purposive sampling method was used. Data were collected through FGDs, in-depth interviews, observation and document reviews Results : Among the main findings of the review is the weakness of the surveillance to detect case; the surveillance system was not that much effective for early detection of viral hemorrhagic fevers and there was knowledge gap to detect in the existing. The Review found out further that preparedness plan was weak, failing to consider the outbreak for VRAM. However, it is worth-noting that the Review showed that despite late detection, a rapid response team was set up and was able to save the lives of many during the outbreak. The findings further showed there was good coordination among various stakeholders at different levels and with satisfying sharing of roles and responsibilities. Conclusion: Based on the major findings, it may be concluded that the surveillance system was weak to detect yellow fever outbreak occurrence in Wolaita Zone. A major gap is therefore the inability to include the case to the IDSR weekly report. Once the case was confirmed, the response to the crisis was fairly commendable. Even though there was a confusion on identifying the first case, after the confirmation of the first case, the case management went as per the standard guideline and SOPs, helping save so many lives through availing the service free of charge Key terms: After Action Review; Outbreak Response; Yellow Fever, Surveillance, Coordination,
Attendance of fourth Antenatal Care Visit in Ethiopia: Analysis from 2016 Ethiopian Demographic Health Survey
Authors: Abrha Mulugeta Woldu , Gebrekidan Brhane Ayele , Weldearegay Haftom Gebrehiwot , Medhanyie Araya Abrha
Published: January 2020

Background Globally, approximately 830 women have been reported to die every day due to complications of pregnancy and childbirth. Almost all of these deaths occurred during the third trimester of pregnancy. This could have been reduced by having adequate Antenatal care visits. However, little is known about the determinants of fourth Antenatal care visit. This study is therefore conducted to identify determinants of attendance of fourth Antenatal visits in Ethiopia. Method This study was an analysis of data collected by the 2016 Ethiopian Demographic and Health Survey which used a stratified, two-stage cluster sampling design. Bivariate and multivariable regression analysis was done to declare association between independent predictors and attendance of fourth Antenatal care visit. Result The independent factors affecting fourth Antenatal visit were highest wealth index (Adjusted Odds Ratio(AOR) = 1.85; 95% Confidence interval (CI) (1.41, 2.44), watching television less than once in a week (AOR= 0.64; 95%CI (0.46, 0.88), not informed about pregnancy complications during previous visit (AOR= 0.59; 95%CI (0.51, 0.70) and women who were not given or who did not buy iron tablets/syrup (AOR= 0.64; 95%CI (0.55, 0.75). Conclusion In this study wealth index, frequencies of watching television, information about pregnancy complication, given or bought iron tablets/syrup were the predictors. Therefore integrated service of proper counseling on birth preparedness and complication readiness, Iron folic acid provision by health care providers and other integrated multi-sectoral collaborations are also highly important to improve the wealth index and health literacy of mothers.
Bottlenecks and met needs for the treatment of severe acute malnutrition in pastoralists: Doolo zone of Somali region, Ethiopia.
Authors: Farah Abdifatah Elmi , Abas Abdulahi Haji , Ahmed Ahmed Tahir
Published: January 2020

Background There is high burden of malnutrition worldwide, including wasting that is compromising growth and development of children and nations. In Ethiopia, severe acute malnutrition (SAM) remains a public health problem. Prevalence of acute malnutrition i.e. wasting is highest (22.7%), (17.5 %) in Somali region of Ethiopia. This study assessed the bottlenecks and met needs for SAM treatment coverage in Doolo zone Somali regional state of Ethiopia. Methods This study used Tanahashi model of service coverage to identify bottlenecks for SAM treatment coverage at health facility platform using multi-stage sampling in Doolo zone, Somali regional state of Ethiopia. T racer interventions were selected to make the analysis more manageable and systematic. The collected data were entered in to excel then thoroughly cleaned and analysed. Indicators for supply-side, demand and quality were calculated. The shortest bar of the graph was considered as a bottleneck for supply-side while sharp decline or drop-in between one bar of the graph to the next was considered as a bottleneck in demand and quality sides. Performance thresholds were set for the indicators as (Good, fair and poor) and met need for SAM was then calculated.ResultThe analysis identified bottlenecks across the six determinants of coverage for the treatment of SAM. Major supply-side bottlenecks identified were commodity stock-outs, mainly ready to use therapeutic foods (RUTF) and shortage of trained health extension workers in three of the four districts studied. On the demand side, despite reasonable initial utilizations in most of the districts studied, there were poor continuity of services (high defaulter rate) and low quality of SAM treatment (effective coverage). The met need was lowest in Bokh district (12%) and highest in Danod district (70%). Despite average treatment coverages of 85% and above for Geladi, Warder and Danod districts, yet the met need was found to be 54%, 60% and 70% respectively which was not commensurate with average treatment coveragesConclusionThe identified bottlenecks for SAM treatment coverage cut across the supply side, demand and quality aspects. The low quality for SAM treatment could have resulted from a combination of supply and demand bottlenecks i.e. frequent stock out of basic commodities (RUTF), shortage of trained health extension workers and poor health-seeking behaviour and/or poor continuity of service or high defaulter rate). The overall met need for SAM program was found to be 37% which could imply high unmet need and poor impact of the program. It is recommended that further causality analysis be undertaken for the major bottlenecks discovered in this study to establish root causes of bottlenecks and devise appropriate solutions adapted to the local setting.