bluuebunny/crossref_metadata_2025 huggingface dataset:
Genomic and Immunologic Correlates in Prostate Cancer with High Expression of KLK2
Authors: Paniagua-Herranz Lucía , Moreno Irene , Nieto-Jiménez Cristina , Garcia-Lorenzo Esther , Díaz-Tejeiro Cristina , Sanvicente Adrián , Doger Bernard , Pedregal Manuel , Ramón Jorge , Bartolomé Jorge , Manzano Arancha , Gyorffy Balázs , Gutierrez-Uzquiza Álvaro , Pérez Segura Pedro , Calvo Emiliano , Moreno Víctor , Ocana Alberto
Published: February 2024

The identification of surfaceome proteins is a main goal in cancer research to design antibody-based therapeutic strategies. T cell engagers based on KLK2, a kallikrein specifically expressed in prostate cancer (PRAD), are currently in early clinical development. Using genomic information from different sources, we evaluated the immune microenvironment and genomic profile of prostate tumors with high expression of KLK2. KLK2 was specifically expressed in PRAD but it was not significant associated with Gleason score. Additionally, KLK2 expression did not associate with the presence of any immune cell population and T cell activating markers. A mild correlation between the high expression of KLK2 and the deletion of TMPRSS2 was identified. KLK2 expression associated with high levels of surface proteins linked with a detrimental response to immune checkpoint inhibitors (ICIs) including CHRNA2, FAM174B, OR51E2, TSPAN1, PTPRN2, and the non-surface protein TRPM4. However, no association of these genes with an outcome in PRAD was observed. Finally, the expression of these genes in PRAD did not associate with an outcome in PRAD and any immune populations. We describe the immunologic microenvironment on PRAD tumors with a high expression of KLK2, including a gene signature linked with an inert immune microenvironment, that predicts the response to ICIs in other tumor types. Strategies targeting KLK2 with T cell engagers or antibody–drug conjugates will define whether T cell mobilization or antigen release and stimulation of immune cell death are sufficient effects to induce clinical activity.
Integrative Epigenetic and Molecular Analysis Reveals a Novel Promoter for a New Isoform of the Transcription Factor TEAD4
Authors: Rashidiani Shima , Mamo Gizaw , Farkas Benjámin , Szabadi András , Farkas Bálint , Uszkai Veronika , Császár András , Brandt Barbara , Kovács Kálmán , Pap Marianna , Rauch Tibor A.
Published: February 2024

TEAD4 is a transcription factor that plays a crucial role in the Hippo pathway by regulating the expression of genes related to proliferation and apoptosis. It is also involved in the maintenance and differentiation of the trophectoderm during pre- and post-implantation embryonic development. An alternative promoter for the TEAD4 gene was identified through epigenetic profile analysis, and a new transcript from the intronic region of TEAD4 was discovered using the 5’RACE method. The transcript of the novel promoter encodes a TEAD4 isoform (TEAD4-ΔN) that lacks the DNA-binding domain but retains the C-terminal protein–protein interaction domain. Gene expression studies, including end-point PCR and Western blotting, showed that full-length TEAD4 was present in all investigated tissues. However, TEAD4-ΔN was only detectable in certain cell types. The TEAD4-ΔN promoter is conserved throughout evolution and demonstrates transcriptional activity in transient-expression experiments. Our study reveals that TEAD4 interacts with the alternative promoter and increases the expression of the truncated isoform. DNA methylation plays a crucial function in the restricted expression of the TEAD4-ΔN isoform in specific tissues, including the umbilical cord and the placenta. The data presented indicate that the DNA-methylation status of the TEAD4-ΔN promoter plays a critical role in regulating organ size, cancer development, and placenta differentiation.
Quantitative Detection of Pipeline Cracks Based on Ultrasonic Guided Waves and Convolutional Neural Network
Authors: Shen Yuchi , Wu Jing , Chen Junfeng , Zhang Weiwei , Yang Xiaolin , Ma Hongwei
Published: February 2024

In this study, a quantitative detection method of pipeline cracks based on a one-dimensional convolutional neural network (1D-CNN) was developed using the time-domain signal of ultrasonic guided waves and the crack size of the pipeline as the input and output, respectively. Pipeline ultrasonic guided wave detection signals under different crack defect conditions were obtained via numerical simulations and experiments, and these signals were input as features into a multi-layer perceptron and one-dimensional convolutional neural network (1D-CNN) for training. The results revealed that the 1D-CNN performed better in the quantitative analysis of pipeline crack defects, with an error of less than 2% in the simulated and experimental data, and it could effectively evaluate the size of crack defects from the echo signals under different frequency excitations. Thus, by combining the ultrasonic guided wave detection technology and CNN, a quantitative analysis of pipeline crack defects can be effectively realized.
EVALUATION OF MICROBIAL POTENTIAL OF RHIZOBACTERIAL ISOLATES ASSOCIATED WITH SPENT MUSHROOM COMPOST AGAINST BACTERIAL WILT OF TOMATO
Authors: Qureshi Farhan Fareed , Haq Muhammad Inam-ul- , Aslam Muhammad Naeem , Abdullah Abuzar , Nasir Abdul , Qasmi Hafiz Muhammad Umar , Batool Amina
Published: February 2024

Bacterial wilt, caused by the soil-borne pathogen Ralstonia solanacearum, poses a significant threat to tomato crops worldwide. This study aims to assess the microbial potential of rhizobacterial isolates obtained from spent mushroom compost in suppressing bacterial wilt of tomatoes. Spent mushroom compost is a byproduct of mushroom cultivation and is known to harbor diverse microbial communities with potential plant-beneficial properties. Tomato leaves that were contaminated were collected from a number of places in the Rawalpindi Area, Punjab, Pakistan. Rhizobacterial isolates were collected from the rhizosphere of tomato plants grown in the presence of spent mushroom compost. These isolates were then subjected to laboratory evaluations for their antagonistic activity against R. solanacearum. Selected rhizobacterial isolates were further characterized for their plant growth-promoting traits. The potential of these isolates to enhance tomato plant growth and confer resistance against bacterial wilt was evaluated through greenhouse experiments. Results indicated that certain rhizobacterial isolates exhibited substantial antagonistic activity against R. solanacearum. Additionally, these isolates demonstrated multiple plant growth-promoting traits, suggesting a potential dual role in both pathogen suppression and plant enhancement. Greenhouse experiments revealed a significant reduction in the incidence of bacterial wilt in tomato plants and increase in the growth promotion traits were observed while treated with the selected rhizobacterial isolates alone and in combination compared to control groups. The findings from this study highlight the promising role of rhizobacterial isolates associated with spent mushroom compost in managing bacterial wilt in tomatoes.
Experimental modeling of dynamic response and speed control of a DC motor using an electronic prototyping board
Authors: Oliveira Luanne Lys de Souza , Oliveira Fabrício Falcão de Souza , Gomes Jéssica da Silva , Río Daniel Guzmán del
Published: February 2024

The modeling and simulation of dynamic systems has become important today due to the strict performance criteria that industrial automation and control systems require in the era of Industry 4.0. This paper presents a study based on experimental modeling of the dynamic response of a DC motor in order to control its speed using a PID controller, with the aim of maintaining the motor's constant rotation speed using the three control actions: proportional, integral and derivative. Thus, the practical implementation is carried out using an Arduino, where speed and voltage data from the open loop system is collected and inserted into the Matlab® tool, so that it is organized and used to generate the respective transfer function of the developed system and therefore control the motor's revolutions per minute.
Efficacy of Extracorporeal Shock Wave and Pulse Electromagnetic Field Therapies in Calcaneal Spurs
Authors: Öztürk Gülşah Yaşa , Yetişir Ayşegül
Published: February 2024

Background: Various treatment methods are available for calcaneal spur, which can cause disability. Objective: To evaluate the efficacy of pulsed electromagnetic field therapy (PEMFT) added to extracorporeal shock wave therapy (ESWT) on pain and functional capacity in treating calcaneal spurs. Methods: Patients with calcaneal spurs who were recommended ESWT or ESWT+PEMFT and whose Foot Function Index (FFI) and visual analogue scale (VAS) values were available in their records were retrospectively analyzed. The two groups were ESWT (n=35) and ESWT+PEMFT (n=40). FFI and VAS scores were obtained from their records before treatment, after treatment, and in the third month after treatment. Results: The two groups were similar regarding their pre-treatment FFI and VAS scores. In intra-group evaluation, statistically significant decreases were found in terms of the FFI pain, disability, and activity limitation and VAS scores in both groups after treatment and in the third month after treatment compared to the pre-treatment period. In the comparison between the groups, the post-treatment and post-treatment third-month FFI pain, disability, and activity limitation and VAS scores were significantly lower in the PEMFT+ESWT group than the ESWT group (P<0.001). Conclusion: A calcaneal spur is a condition that can cause pain and functional limitation in patients. Various studies have demonstrated the efficacy of ESWT in the treatment of calcaneal spurs. In our study, we observed that PEMFT added to ESWT significantly improved the pain and functionality of the patients. Further studies are needed to evaluate the efficacy of PEMFT in calcaneal spurs.
Safety and Effectiveness of Cinnomer® on Disease Characteristics, Depression, and Quality of Life of Patients with Multiple Sclerosis: A Phase IV, Post-marketing, Prospective, Multicenter Study
Authors: Naser Moghadasi Abdorreza , Ashtari Fereshteh , Baghbanian Seyed Mohammad , Shaygannejad Vahid , Anjidani Nassim , Ghadiri Fereshteh , Sedighi Behnaz , Saeidi Morteza , Amirifard Hamed , Ayromlou Hormoz , Beladi Moghadam Nahid , Ranjbar Mohammad Bagher , Nazeri Masoume , Niknam Zahra , Faraji Fardin , Afsorde Afsaneh , Sahraian Mohammad Ali
Published: February 2024

Background: Every patient diagnosed with definite multiple sclerosis (MS) should begin disease modifying therapies. Cinnomer® contains 40 mg glatiramer acetate (GA) and is available in prefilled syringes and autoinjector devices. Methods: A phase IV multicenter study was conducted to explore the safety and effectiveness of Cinnomer® in the treatment of MS. Study-related data were collected for 14 months. Results: Totally, 368 Iranian relapsing-remitting MS patients in nine cities were enrolled. The patients were either treatment naïve (n=191) or switchers (n=177). Cinnomer® treatment was associated with a significant reduction in annual relapse rate (ARR) (RR: 0.65, 95% CI: 0.43, 0.98). Final mean Expanded Disability Status Scale (EDSS) scores showed improvement from baseline (difference: -0.21, 95% confidence interval (CI): -0.34, -0.08). There was a significant decrease in gad-enhancing lesions during treatment (difference: -0.38, 95% CI: -0.64, -0.12). The mean score for the depression measure (21-item BDI-II questionnaire) significantly improved (difference: -2.39, 95% CI: -3.74, -1.03). There was a significant change in the "psychological well-being" dimension (P=0.02) (in line with BDI-II scores) and "rejection" MusiQoL dimensions (P=0.04). The adverse events documented throughout the study were not unexpected for GA and were principally not serious. Conclusion: Safety measures were in line with the known profiles of GA. The results suggest that Cinnomer® is effective with respect to clinical outcomes and from the patient’s perspective and in reducing MRI-measured MS activity.
Cardiac Mass and Cerebrovascular Accident as Primary Manifestations of Churg-Strauss Syndrome
Authors: Abbasi Fariba , Abbasi Ata , Rostamzadeh Alireza , Banihashemi Seyede Zohre , Rajabi Aliakbar
Published: February 2024

Churg-Strauss syndrome (CSS), recently named eosinophilic granulomatosis with polyangiitis (EGPA), is a rare form of systemic vasculitis with extravascular granulomas occurring in patients with asthma and tissue eosinophilia. We represent a large left ventricular granuloma, confirmed by histopathologic evaluation, detected as a ventricular mass by echocardiography in a 45-year-old asthmatic male who was admitted for a cerebrovascular accident. Paraclinical and histopathologic findings confirmed the diagnosis of EGPA. As cardiac involvement in patients with EGPA is associated with poor prognosis, routine echocardiographic evaluation of these patients is suggested.
Comparison of the Effect of Fluoride 0.2% and a Combined Mouthwash (Flavonoid Compounds and Fluoride 0.2%) Against Streptococcus mutans and Lactobacillus acidophilus: In Silico and In Vitro Study
Authors: Omidi Behin , SarveAhrabi Yasin , Nejati Khoei Sarina
Published: February 2024

Background: Tooth decay is one of the most common health problems in the world. Nowadays, finding new compounds to prevent tooth decay is more necessary than ever. The purpose of this study was to compare the effects of fluoride 0.2% and mouthwash combined with flavonoid compounds against bacterial samples. Methods: The crystal structures of glucansucrase from Streptococcus mutans and glucan-1, 6-alpha-glucosidase from Lactobacillus acidophilus were obtained from the Protein Data Bank. By using AutoDockTools (1.5.7), ligands and protein interactions were calculated and ready for AutoDock vina. The agar well diffusion and the minimum inhibitory concentration/minimum bactericidal concentration (MIC/MBC) methods were used to investigate the inhibitory effect of mouthwashes, and the results were obtained with SPSS software. Results: Compounds eriocitrin and galangin showed the highest amount of H-bonds with amino acids against glucansucrase. In addition, catechin, eriocitrin, and isorhamnetin compounds demonstrated the highest amount of H-bonds with amino acids against glucan-1, 6-alpha-glucosidase. In vitro results revealed that groups a (Fluoride 0.2%+eriocitrin against S. mutans) and d (Fluoride 0.2%+eriocitrin against L. acidophilus) represented the most effect among all compounds, respectively (Inhibition zone=26±0.5 mm, MIC=250 µg/mL, MBC=500 µg/mL and inhibition zone=31±0.5 mm, MIC=125 µg/mL, MBC=250 µg/mL). Conclusion: Fluoride 0.2% with eriocitrin was more effective in both methods (In silico and in vitro) compared to fluoride 0.2% due to its good inhibitory effect at different concentrations against S. mutans and L. acidophilus.
Comparison of the Remineralization Effect of Nano Herbal Toothpaste With Two Kinds of Toothpaste Containing Fluoride and Bioactive Glass on Primary Enamel Lesions: An In Vitro Study
Authors: Asgartooran Bahareh , Shokripour Mohadese , Ayubi Erfan , Abdol Alireza , Alibakhshi Zahra
Published: February 2024

Background: Considering the therapeutic properties of the compounds used in Albodent Iranian toothpaste and little evidence about the effect of NovaMin toothpaste on primary caries lesions, the purpose of this research was to compare the effect of toothpaste containing fluoride and toothpaste containing bioactive glass with Albodent toothpaste on enamel remineralization in a laboratory manner. Methods: Overall, 24 healthy human premolar teeth were selected and divided into buccal and lingual halves. The demineralization cycle of the samples was performed for 14 days. The samples were classified into four groups and were brushed twice a day for 28 days with tested toothpaste. A microhardness test was conducted, and changes in the enamel surface and morphology of one sample selected from each group were evaluated by scanning electron microscopy. The analysis of variance and Tukey’s tests were used for the statistical analysis of the data. Results: The average difference in microhardness in the studied groups was statistically significant (P<0.05) when compared two-by-two with the control group. The most noticeable difference was found in the comparison of the Sensodyne group with the control group, while the lowest difference was observed in the comparison of the Albodent group with the control group. Conclusion: The presence of NovaMin in toothpaste along with fluoride can increase the efficiency of the remineralization rate of primary enamel lesions compared to fluoride toothpaste without bioactive glass. In addition, the effectiveness of herbal toothpastes, which do not contain essential artificial ingredients in the remineralization of primary enamel lesions was lower than that of non-herbal fluoride toothpastes.
Assessment of Periapical Status in Posterior Root Canal-Treated Teeth Using Cone Beam Computed Tomography in the Iranian Population
Authors: Foroozandeh Maryam , Ehsani Azita , Khazaei Salman
Published: February 2024

Background: Periapical radiolucency occurs due to root canal infections. In this respect, effective root canal treatment and appropriate coronal restoration can aid in preventing these lesions. Thus, the present study aimed to assess the periapical status in posterior root canal-treated teeth by cone-beam computed tomography (CBCT) in the Iranian population. Methods: The CBCT images of 210 patients (475 endodontically treated molars and premolars) referred to the Hamadan Dental School (from 2020 to 2022) were evaluated in this observational study. The images were obtained by a NewTom 3G CBCT device (NewTom, Verona, Italy) with an FOV of 6×6 inches at 110 kVp and varying milliampers and exposure times according to the patient’s age and body size. They were observed by two maxillofacial radiologists who recorded the periapical status, coronal seal, and endodontic treatment quality of root canal-treated teeth. The Chi-square test was used for data analysis (P≤0.05). Finally, the periapical lesion was determined, along with its association with gender, type of tooth, endodontic treatment quality, and appropriate restoration. Results: The results revealed no significant association between periapical radiolucency and gender. The prevalence of periapical lesions was higher in males aged 25–50 years, but no significant correlation was found in this regard. There was no significant relationship between tooth type and the presence of periapical lesions, while it had the highest prevalence in maxillary molars. Endodontic treatment quality and coronal restoration showed significant correlations with the presence of periapical radiolucency. Conclusion: There was no significant association between the presence of periapical radiolucency and gender and age. The prevalence of periapical lesions was higher in males. Cases with poor endodontic treatment and poor restoration demonstrated the highest prevalence of periapical lesions.
The effect of eight weeks of high-intensity interval training on the expression of mir-126, EMAP-II, and levels of TGF-β in the heart tissue of young rats with type 2 diabetes
Authors: Bagherinia Maryam , Abedi Bahram , Fatolahi Hosein
Published: February 2024

Background and aims: Diabetes affects some cardiac angiogenic and antiangiogenic markers. Thus, the aim of this study was to investigate the effect of eight weeks of high-intensity interval training (HIIT) on mir-126, endothelial monocyte-activating polypeptide II (EMAP-II), and transforming growth factor beta (TGF-β) in young rats with type 2 diabetes (T2D). Methods: The statistical population of this experimental study included young rats (8 weeks old) with T2D. In this research, 24 young rats (8 weeks old) were divided into healthy+HIIT, diabetic+HIIT, and healthy control groups. The enzyme-linked immunosorbent assay method was used to measure TGF-β and the real-time polymerase chain reaction for mir-126 and EMAP-II. A one-way analysis of variance and the least significant difference post hoc test were used to compare the two groups. Results: The results showed diabetes+HIIT and healthy+HIIT had more mir-126 compared to healthy control (P=0.001). Healthy+HIIT, in comparison to diabetes+HIIT, had higher mir-126 expression (P=0.001). In addition, diabetes+HIIT, compared to the healthy control, had a higher EMAP-II expression (P=0.006). On the other hand, healthy+HIIT had lower EMAP-II in comparison to healthy control (P=0.001). Healthy+HIIT had a lower EMAP-II compared to diabetes+HIIT (P=0.001). Diabetes+HIIT, in comparison to the healthy control, had higher TGF-β levels (P=0.005). However, healthy+HIIT, compared to healthy control, had a lower expression of TGF-β (P=0.001). Finally, the healthy+HIIT groups, compared to the diabetes+HIIT group, had a lower TGF-β expression (P=0.001). Conclusion: Interval exercise could increase angiogenesis in diabetic samples through the increase of mir-126 and the reduction of TGF-β1 and EMAP-II.
Investigation of the effects of Terminalia chebula seed hydroalcoholic extract on Paraoxonase1 enzyme activity in rats
Authors: Taghipour Parastoo , Rostamian Sahar , Mobini Gholamreza , Ghatreh-Samani Keyhan , Rafieian-Kopaei Mahmoud , Saffari-Chaleshtori Javad
Published: February 2024

Background and aims: Paraoxonase 1 (PON1) is related to high-density lipoprotein (HDL) in serum and protects against low-density lipoprotein (LDL) oxidation. This study aimed to investigate the effects of Terminalia chebula on PON1 in hyperlipidemic rats and the molecular docking effects of some compounds of this medical plant on PON1 activity. Methods: Overall, 40 male rats (200–250 gr) were randomly divided into four groups, including the control group, the hyperlipid group, the hyperlipid group receiving 400 mg/kg of the hydroalcoholic extract of T. chebula seeds, and the hyperlipid group receiving 800 mg/kg of the hydroalcoholic extract of T. chebula seeds. The PON1 arylesterase activity in serum and the PON1 gene expression in the liver tissue underwent investigation. Then, the molecular docking effects of its compounds were studied on PON1 through in-silico studies using the AutoDock software (version 4.2.0). Results: T. chebula decreased (P<0.001) the serum triglycerides from 105.88±10.15 mg/dL in the hyperlipidemic group to 66.88±14.90 and 74.25±9.51 mg/dL in hyperlipidemic groups receiving 400 and 800 mg/kg of the hydroalcoholic extract of T. chebula seeds, respectively. In addition, the PON1 serum aryl esterase activity increased from 202.12±6058 in hyperlipidemic rats to 224.34±58.74 (P=0.83) and 235.80±37.05 (P=0.6) in hyperlipidemic groups receiving 400 mg/kg and 800 mg/kg of the hydroalcoholic extract of T. chebula seeds, respectively. It also demonstrated a significant effect on PON1 gene expression (P<0.001). In addition, the in-silico and docking results revealed that the main antioxidant compounds of T. chebula, such as catechin, kaempferol, and quercetin, could bind to the PON1 enzyme directly and influence the enzyme activity. Conclusion: T. chebula increased PON1 activity and PON1 gene expression. However, among the plant’s compounds, catechin, kaempferol, and quercetin played the most substantial role in the PON1 activity. It seems that these compounds can be useful as co-treatments in hyperlipidemia therapies.
Technical and Semantic Aspects in Viorel Munteanu’s Symphony No. 2
Authors:   “George Enescu” National University of Arts Iași, RUSU Mihaela
Published: February 2024

Symphony No. 2, a recent creation of composer Viorel Munteanu (first performance in 2021), is a fascinating, modern and provocative work. It is part of the “Shadows and Genesis” cycle, accumulating the effort of over thirty years of experience: “My shadows and genesis are quasi-permanent sources of inspiration; they are themes always born and reborn from my own evolution”1 . Symphony No. 2 stands out through the massiveness of its structure, the originality of the orchestration and its character deeply anchored in Romanian folklore motifs. The sources of inspiration, “shadows and genesis”, can be recognized, through references to previous creations and to Enescu’s music, as well through its use of the “George Enescu” melogram. The symphonic work is made up of five parts, entitled suggestively: - I. Imprints, II. Contrasts, III. Heterophonies, IV. Byzantine Sources, V. Dance of colors. This paper presents the compositional techniques, Viorel Munteanu’s fascination for the melograms - melodic “codes” transformed into the main thematic profile - and proposes an interpretation of the sound images generated by the expressive orchestration and thematic richness.
Festival d’Avignon – The Challenges of a Doctoral Documentation
Authors:   “George Enescu” National University of the Arts, Iași, DARIE Andreea
Published: February 2024

In my doctoral research, even though I chose the scientific route and not the professional one, I sought to expand the theoretical discourse in various applicative areas. In order to understand the springs of clowning and the psychosomatic structure of the clown actor, I conducted a non-verbal monologue study about the trickster, I participated in physical and online workshops with clowning teachers from the UK and Spain and, last but not least, I conducted together with an interdisciplinary team a niche theatrical laboratory with the theme: the clown condition of some dramatic characters. After all these practical extensions of the research, it was my turn, this summer, to undertake a documentary visit to the Avignon Festival. I had planned to watch shows that clearly contain a clownish expression, but also shows where I could identify it based on criteria defined in my research. Thus, I discovered that getting to Avignon during the festival is an adventure in itself. You risk yourself into a heterogeneous theatrical dynamics that is difficult to assimilate. The diversity of events that take place both in the courtyard of Palais des Papes and in several hundred other locations in the old town, but also in five other neighbouring towns – Châteauneuf-du-Pape, Monteux, Courthézon, Vedène and Noves – surpasses any other festival approach from Europe. This fact complicates the options for any viewer, competent or not. This year, in the official section (July 7-26), there were more than 40 events, some resumed in consecutive days, resulting in several hundred performances, all of them sold out. The “Off” section of the festival had a longer duration (July 7-30) and 1570 performances, each show having multiple performances, some even running the entire duration of the festival. No mathematical calculations are needed to get an idea of the artistic effervescence of those summer days in the south of France.
Lack of Documentation on the Phenomenon of Body Shaming in Romania. In Search of a Method…
Authors:   “George Enescu” National University of the Arts, Iași, RADU Alexandru
Published: February 2024

My research is based mainly on the vast phenomenon that we call body shaming. Although it has existed for a long time in social interactions, the phenomenon has inevitably spread much faster with the evolution of social media platforms, and is part of the wide range of contemporary psycho-somatic disorders. In a first analysis of the subject, we can formulate the false impression that body shaming is an isolated manifestation of negative remarks, about one individual’s weight by another, in order to denigrate it. But if we look at the depth of the psychic processes that arise from such an interaction, we see that, in fact, body shaming has far more complex implications in everyday life. For example, certain verbal expressions we use daily can become triggers of bodily trauma to those around us, without our intention having any derogatory purpose. Internationally, the phenomenon has already raised some question marks among psychologists and industries that include working with body shapes, thus forming an opportunity to study the triggering mechanisms of body shaming, its forms and the effects it can have on an individual. Society itself has become familiar with the harmful effects and has developed an ability to censor itself in such situations. In Romania, however, the phenomenon is just beginning to be introduced into society as a real problem of the 21st century, research on it being even less common
Nivel de conocimiento sobre cultura financiera en estudiantes de Educación Superior
Authors: Moreno Nasimba Elsa de los Angeles
Published: February 2024

La importancia del crecimiento económico que tiene un país está ligada al conocimiento sobre educación financiera que tiene la población. Algunas dificultades que tiene la población de jóvenes ecuatorianos son: endeudamiento, falta de liquidez mensual y desconocimiento de conceptos básicos. El objetivo del estudio fue diagnosticar el nivel de conocimiento sobre cultura financiera de una muestra de 349 jóvenes de entre 18 a 30 años de edad que están cursando estudios universitarios en carreras financieras. Se describieron tres características: planificación y manejo de las finanzas, comportamiento y actitudes financieras y conocimiento financiero, para evaluar el nivel de conocimiento de la cultura financiera de los estudiantes encuestados. La mayoría de los jóvenes de la muestra denotan una vulnerabilidad financiera para llegar a fin de mes con relación a sus gastos mensuales. Los estudiantes prevén un mes para sobrevivir sin una fuente de ingreso mensual en caso de quedarse sin empleo. El 93,39% tiene interés en realizar capacitaciones para mejorar su conocimiento de educación financiera. Por tal motivo, se deben establecer capacitaciones sobre toma de decisiones financieras, informadas como un pilar fundamental de la inclusión económica para fortalecer la administración de recursos, desarrollar habilidades para realizar inversiones que satisfagan sus necesidades básicas mensuales.
Pengetahuan dan Sikap Ibu Rumah Tangga dalam Pencegahan Kanker Servik
Authors: Andanawarih Putri , Ulya Ni’matul , Artanti Swasti
Published: February 2024

Cervical cancer caused by HPV (human papillomavirus) usually attacks women aged between 35 and 55 years and ranks second as the type of cancer most commonly experienced by Indonesian women. Early detection of cervical cancer is done with the visual acetic acid test (IVA). The aim of this research was to determine the knowledge and attitudes of housewives in preventing cervical cancer in the Pringrejo Village area. This research used a cross-sectional method with the Kolmogorov Smirnov reliability test with a sample size of 100 respondents. Both tests were calculated using SPSS version 17 for Windows. The results of the research show that age, education, economic status and knowledge influence the attitudes and behavior of housewives regarding cervical cancer with a p value for each characteristic <0.10. In the results, job characteristics have no relationship with the attitude of housewives in preventing cervical cancer because the p value is > 0.10. With this research, it is hoped that health workers can provide clear information about cervical cancer to the wider community, especially housewives.
Pengetahuan tentang Manajemen Laktasi pada Ibu Menyusui Mendukung Keberhasilan ASI Eksklusif
Authors: Wardani Endah Kusuma , Magfiroh Reni Ulfa Lailatul , Purnamasari Desy
Published: February 2024

Promoting breastfeeding is one of the objectives to be attained under the Sustainable Development Goals (SDGs) policy. Coverage of breastfeeding, both globally and regionally, still needs to meet standards, and one of the elements that can impact breastfeeding success is the extent of the mother's knowledge about lactation management. This study aimed to analyze the correlation between the level of knowledge about lactation management and exclusive breastfeeding in breastfeeding mothers. This study was designed as an observational analytic research utilizing a cross-sectional approach. The sample comprised 51 individuals, selected using random sampling technique that fulfilled the predetermined criteria for inclusion (breastfeeding mothers aged 6-12 months) and exclusion criteria (mothers with comorbidities). This study was conducted in the working area of the Tulungrejo Community Health Center in December 2023. To assess the mother's understanding of lactation management, a questionnaire was utilized as the research instrument. The chi-square test with the assistance of the SPSS 25 software was applied to analyze the data. The results indicated that 45.1% of mothers had sufficient knowledge, and 52.9% did not breastfeed exclusively. Statistical test results p value 0.000 < 0.05 indicated a correlation between between the knowledge level of lactation management and exclusive breastfeeding. The expectation is for health workers and breastfeeding support groups to play a significant role in educating mothers about lactation management during pregnancy, which is carried out consistently so that mothers can provide breast milk exclusively to babies.
Hubungan Keragamanan Makanan dengan Status Gizi Balita Usia 1-5 Tahun
Authors: Yulianti Neng Yani , Utami Nendhi Wahyunia , Astuti Endah Puji
Published: February 2024

Food diversity is a major problem for all developing countries, including Indonesia. Dietary diversity is associated with the risk of stunting and other nutritional problems. Stunting will have a negative impact on children's thinking, memory, school performance and work productivity in the future. In an effort to reduce the high stunting rate in Sumberwungu Village, the Government was distributing additional food in the form of snacks but it was not in accordance with nutritional needs. The aim of this research was to determine whether the nutritional status of toddlers aged 1-5 years was related to diversity in Sumberwungu Village, Tepus, Gunung Kidul, Yogyakarta. This type of research uses a retrospective methodology and is an analytical observational study. The sample in the research was 34 toddlers who experienced nutritional problems. Food diversity data was collected using the IDDS questionnaire with a non-consecutive 2x24 hour recall method. The data analysis used in this research is univariate and bivariate analysis. Bivariate analysis in this study uses the Kendal-Tau test to determine the relationship between food diversity and the nutritional status of toddlers. The results of data analysis showed that there was no relationship between food diversity and nutritional status in toddlers aged 1-5 years (z score BB/U p= 0.898, z score TB/U p= 0.941, and z score BB/TB p= 0.913).
Precios de Garantía e Impuesto Predial Rústico en Mercado del Maíz Blanco
Authors: Zúñiga-Espinoza Nicolás Guadalupe
Published: February 2024

El objetivo fue estimar el impacto que tendrán los precios de garantía y de mercado del maíz blanco sobre el impuesto predial rústico para el 2023. Se utilizaron datos del Sistema de Información Agropecuaria y Pesquera (SIAP, 2022). El método utilizado es el deductivo y la investigación es de tipo explicativa y descriptiva. Los resultados indican que otorgar precios de garantía solo a productores de hasta 15 hectáreas y, excluir a los que sembraron más allá de esa superficie, afectará la recaudación. Entre los hallazgos se tiene la importancia de la siembra de maíz blanco para financiar obras públicas en comunidades rurales. Su originalidad radica relacionar la producción del maíz con el principal impuesto local de los gobiernos municipales: el predial. Por limitaciones no se pudo tener acceso al mecanismo de recaudación descentralizado, a partir de junio del presente año, para administrar dicho tributo.
Construcción y validación de un instrumento para evaluación de crisis familiares
Authors: Díaz Vega Gloria , Terrazas Rodríguez Luz Dalid
Published: February 2024

Introducción: Hoy día, se ha evidenciado una creciente en las crisis familiares por lo que resulta trascendente diseñar un nuevo instrumento documental para la evaluación de crisis familiares. Objetivo: Construir y validar un instrumento para la evaluación de crisis familiares. Materiales y métodos: En la evaluación cualitativa, se estimó la validez de contenido a través de la selección de 10 expertos, quienes a través de una guía de observación evaluaron la suficiencia, pertinencia y claridad de los ítems redactados. Los expertos hicieron observaciones que se tomaron en cuenta, dando lugar a una segunda ronda. Posteriormente se aplicó la prueba piloto a 260 derechohabientes mayores de 18 años, ambos sexos, donde los participantes hicieron sugerencias sobre el instrumento, por lo que se realizó una segunda prueba piloto. En la evaluación cuantitativa se estimó la validez interna y externa a través de la validez de constructo, la fiabilidad, la estabilidad y la validez de criterio. Finalmente, se construyó un instrumento de 9 dominios (matrimonio, expansión, dispersión, independencia, retiro, desmembramiento, incremento, desmoralización y desorganización) con 52 ítems. Resultados: Se validó un instrumento para evaluar crisis normativas y paranormativas con capacidad discriminatoria, arrojando varianzas distintas y una correlación de Pearson positiva. La fiabilidad fue de 0.965 a través del coeficiente alfa de Cronbach y un índice de Kappa de Cohen 0.843 para la reproducibilidad. El modelo regresión lineal confirmó la eficacia para predecir crisis normativas y paranormativas. Conclusiones: Se construyó y validó un instrumento, que permitirá evaluar crisis normativas y paranormativas.
Augmented Surgical Treatment in Patient with Partially Accomodative Esotropia
Authors: PRADISTYA SYIFA YUDIASARI  , Feti Karfiati  , Mayasari Wahyu Kuntorini  , Irawati Irfani  , Primawita Oktarima  , Sesu Caesarya
Published: February 2024

Introduction : Esotropia is a disorder of the position of the eyeball when the eye deviates inward. Surgical treatment is indicated when the eyes are not aligned with the glasses. We report a case of augmented surgical treatment in a partially accommodative esotropia patient.

Case Illustration : A 18-year-old girl comes to the hospital with vision loss in both eyes since 1 year prior admission. Ocular alignment sinne correction was 300 (Figure 1) and cum correction was 150. Prism alternate cover test (PACT) showed deviation in sinne correction distance 60?BO dan near 50?BO, and deviation in cum correction distance 40?BO dan near 35?BO. Surgical formula with augmented surgery was (60?BO + 40?BO)/2 equal to 50?BO. Patient was diagnosed with Compositus Hypermetropia ODS + Partially Accommodative Esotropia. Patient underwent bilateral medial rectus recess surgery of 6 mm. Ophthalmology examination after 1 and 2.5 month surgery showed ocular alignment without spectacles showed microtropia and with spectacles showed orthotropia (Figure 2, 3a and 3b).

Discussion : Various approaches can improve outcomes, including using different surgical formulas. Augmented surgery are the mean of deviation with and without surgery as the final deviation surgical formula.

Conclusion : The amount of surgery in strabismus was based on the size of preoperative deviation. Augmented surgical treatment can be one of the choices to determine preoperative deviation in an esotropia patient.
RIGID GAS PERMEABLE USAGE IN AMBLYOPIC PATIENTS: IS IT SECURE ENOUGH?
Authors: Septian Dwi Prabowo  , Christina Aritonang
Published: February 2024

Introduction : Amblyopia and anisometropia are frequently diagnosed during preschool. Several treatments approaches are currently being prescribed to reduce myopia progression, such RGP.

Case Illustration : A-17-years-old-patient came with blurry vision in both eyes since elementary school. Since Junior High School patient always felt un-comfort using spectacles and routinely check for 6 months. Initial visual acuity was 2/60 pinhole 5/30 and 4/60 pinhole 5/12 in the right and left eye. The previous spectacles were S-4.75 C-1.50 A0 become 5/20 and S-9.00 C-3.50 A0 become 5/6.5 in the right and left eye. After correction S-11.00 C-4.00 A180 become 5/6.5 and S-9.00 C-3.50 A0 become 5/6.5. Due to high myopia, RGP contact lenses were fitted. RGP contact lenses that are given to this patient were BC 8.10 mm/P -9.00D/ D 9.2mm in right eye, and BC 8.00 mm/ P -8.50D/ D 9.2mm in left eye, and visual acuity become 5/6.5 in both eyes.

Discussion : Management of anisometropia can be accomplished through a variety techniques. In cases of severe anisometropia, contact lenses are frequently utilized for refractive correction such as RGP, that is produced in a larger variety of powers, can fit in a certain base curve or diameter, has high oxygen permeability, improved durability, increased contrast sensitivity, and correct higher corneal astigmatism and decreased amblyopia

Conclusion : The risk-benefit and patients' low compliance haven't yet provided a definitive answer. RGP contact lens is secure and practical in the treatment of anisometropia and amblyopic patients. All of which are crucial for achieving the greatest vision and comfort possible following adaptation.
Managing Periorbital Necrotizing Fasciitis: How Invasive Should We Go?
Authors: Andi Marsa Nadhira  , Lia Amanda  , Muhammad Shafiq Advani  , Lukman Edwar
Published: February 2024

Introduction : Periorbital necrotizing fasciitis (PNF) is rapidly progressive and severe infection that may result in vision loss, serious facial disfigurement, and death. Primary management includes surgical debridement; however, here we report a case in which conservative approach resulted in favorable resolution.

Case Illustration : A 24-year-old male presented with swollen right upper eyelid, with watery eye, pain, and blurry vision since 1 week prior. No history of trauma or known systemic diseases was reported. Restricted movement of the right eye (RE), slight nonaxial proptosis, and skin defect along the right superior palpebra with pus, blood, necrotic and granulation tissues were found. Visual acuity (VA) of RE decreased to 6/40 with normal intraocular pressure. No abnormalities on the left eye, fever, and other signs of systemic involvement were present. Contrast orbital computed tomography (CT) scan revealed right preseptal and postseptal tissue lesions, suggesting orbital cellulitis. Initial blood work showed leukocytosis, elevated neutrophil and lymphocyte counts, and high liver function markers. The diagnosis of right orbital cellulitis with PNF was established. Skin swabs and blood cultures were taken, while intravenous ampicillin-sulbactam, bedside wound debridement, and chloramphenicol ointment application were initiated. The swab culture later showed Acinetobactersp. The infection improved, VA was restored to 6/6, and wound closure was achieved without any surgery.

Discussion : Management of necrotizing fasciitis localized in periorbita in an otherwise healthy patient may be successfully accomplished with a less invasive approach.

Conclusion : Timely diagnosis and correct antibiotic therapy are mandatory to decrease morbidity and mortality related to PNF.
Bilateral Ocular Leprosy An Effect By Erythema Nodusum Leprosum : A Case Report
Authors: PETER SALMON  , Monica Camilla Chandra  , Elbetty Agustina br.Simanjuntak,MD  , Ivonne Ramenusa, MD
Published: February 2024

Introduction : Leprosy or Hansen’s disease is an infection caused by Mycobacterium leprae that primarily affects the skin, the peripheral nerves and the eyes, causing chronic granulomatous inflammation.

Case Illustration : We present a case of lepromatous leprosy with erythema nodosum leprosum of a 47 years old man with bilateral and asymmetrical ocular complications. One year ago patient consumed multidrug therapy for leprosy for one year but didn’t finish the medication. On the right eye diagnose with chronic anterior and intermediate uveitis, on the left eye with panuveitis. Best corrected visual acuity (BCVA) was 2/60 for right eye and light perception for left eye. Intraocular pressure were within normal limits. Madarosis and corneal hypoesthesia were found on both eyes. On the right eye was found cells, synechia anterior and posterior, iris pearls and vitreous haze. On the left eye was found plasmoid iridocyclitis and vitreous opacities from USG. Slit skin smear (SSS) result positif acid fast bacilli (AFB) dan granular. Patients were treated with multidrug therapy for leprosy, topical antibiotics, atropine and steroids, oral antibiotics and treatment from a dermatologist.

Discussion : The diagnosis of lepromatous uveitis (LU) in this patient is made through skin tissue biopsy and ophthalmological examination. The effective management of ocular leprosy depends on early diagnosis and appropriate treatment. Hence it is imperative for ophthalmologist to recognize the ocular clinical signs associated with leprosy.

Conclusion : Most blindness and impaired vision resulting from leprosy is preventable. A multidisciplinary approach is to be taken in order to improve the prognosis.
CHALLENGING DIAGNOSIS AND MANAGEMENT OF INFECTIOUS SCLERITIS COMPLICATED WITH CORNEAL PERFORATION CAUSED BY MULTI DRUG RESISTANT Proteus mirabilis
Authors: Pranandito Trunogati  , Herwindo Dicky Putranto  , Rosy Aldina
Published: February 2024

Introduction : Scleritis is a destructive inflammatory disease of sclera and may involve the cornea that associated with an underlying systemic disease and smaller minority are due to infections. The two conditions closely mimic each other, and diagnostic delay can lead to a poor outcome

Case Illustration : A 72 year old male presented with severe pain, redness, swelling, and dimness of vision in his left eye. On slitlamp examination, a superonasal scleral nodule with overlying conjunctival defect and corneal ulcer was found. Both ANA test and RA factor were negative. Microbiological investigations of the lessions revealed MDR Proteus mirabilis. His left eye rapidly deteriorated leading to an impending perforation of the sclera and corneal perforation despite intensive antimicrobial therapy, then patient underwent a tibial periosteal graft on his left eye. Although the visual prognosis was poor, structural integrity of the eye was achieved

Discussion : Infection is a rare cause of scleritis. Among the organism reported till date, Proteus mirabilis, a gram negative, rod shaped bacterium is the rarest to found. The inciting factors are mostly surgical. There was history of cataract surgery on left eye in this case

Conclusion : infectious scleritis is often initially diagnosed as autoimmune, and cause diagnostic delay, the aggressive nature of the associated microbes further complicates the situation. Appropriate diagnosis generally includes lession scrapings with thorough culturing and antibiotic sensitivity testing. Both adequate medical and surgical methods are needed to save the globe from loss