bluuebunny/crossref_metadata_2025 huggingface dataset:
Serum Levels of FGF21, β-Klotho, and BDNF in Stable Coronary Artery Disease Patients With Depressive Symptoms: A Cross-Sectional Single-Center Study
Authors: Wu Yeshun , Chen Zijun , Duan Jiahao , Huang Kai , Zhu Bin , Yang Ling , Zheng Lu
Published: January 2021

Background:The incidence of depressive symptoms (DS) in patients with stable coronary artery disease (SCAD) is significantly higher than those in healthy population, and that DS are independent risk factors for cardiovascular events. Previous studies have reported that fibroblast growth factor 21 (FGF21), β-klotho, mature brain-derived neurotrophic factor (mBDNF), and BDNF precursor (proBDNF) play important roles in the pathogenesis and treatment of coronary heart disease and depression. With this in mind, the present study aimed to clarify the relationship between FGF21, β-klotho, mBDNF, and proBDNF and SCAD with comorbid depression, in addition to also exploring the underlying mechanisms of these disease processes.

Methods:A total of 116 patients with SCAD and 45 healthy controls were recruited. Patients with SCAD were further divided into two subgroups based on the Zung Self-Rating Depression Scale (SDS), which were characterized as those with no DS (NDS) and those with DS. Baseline data were collected, and serum levels of FGF21, β-klotho, mBDNF, and proBDNF were determined.

Results:In SCAD patients, Gensini scores—denoting the degree of coronary arteriostenosis—were significantly greater in the DS group than in the NDS group. There was also a positive correlation between the Gensini scores and the SDS scores. Patients in the SCAD group demonstrated a lower serum FGF21. Serum β-klotho, mBDNF, and mBDNF/proBDNF were also significantly lower in the DS group than in the NDS group. Furthermore, β-klotho and mBDNF were negatively correlated with the SDS scores. Additionally, SCAD patients were divided into lower- and higher-level groups using hierarchical cluster analysis, with the results highlighting that patients in the lower mBDNF group had a higher incidence of DS.

Conclusions:The depression score was positively correlated with the severity of coronary artery stenosis, and serum FGF21, β-klotho, mBDNF, and proBDNF were closely related to the development of DS in patients with SCAD. These observations suggest FGF21, β-klotho, mBDNF, and proBDNF as potential diagnostic and/or therapeutic targets for SCAD with co-morbid depression.
Perceived Stress, Hope, and Health Outcomes Among Medical Staff in China During the COVID-19 Pandemic
Authors: Zhang Xin , Zou Rong , Liao Xiaoxing , Bernardo Allan B. I. , Du Hongfei , Wang Zhechen , Cheng Yu , He Yulong
Published: January 2021

This study investigated the buffering role of hope between perceived stress and health outcomes among front-line medical staff treating patients with suspected COVID-19 infection in Shenzhen, China. In the cross-sectional study with online questionnaires, medical staff's perceived stress, anxiety, depression, sleep quality, and hope were measured by the 10-item Chinese Perceived Stress Scale, Hospital Anxiety and Depression Scale, the Pittsburgh Sleep Quality Index, and the Locus-of-Hope Scale, respectively. A total of 319 eligible front-line medical staff participated. The prevalence of anxiety (29.70%), depression (28.80%), poor sleep quality (38.90%) indicated that a considerable proportion of medical staff experienced mood and sleep disturbances during the COVID-19 pandemic. Internal locus-of-hope significantly moderated the effects of stress on anxiety, depression, and sleep quality. Moreover, external family locus-of-hope and external peer locus-of-hope significantly moderated the association between perceived stress and depression. The prevalence of symptoms indicates that both mental and physical health outcomes of front-line medical staff deserve more attention. Internal and external locus-of-hope functioned differently as protective factors for medical staffs' health and might be promising targets for intervention.
Prospects and Challenges of Green Hydrogen Economy via Multi-Sector Global Symbiosis in Qatar
Authors: Eljack Fadwa , Kazi Monzure-Khoda
Published: January 2021

Low carbon hydrogen can be an excellent source of clean energy, which can combat global climate change and poor air quality. Hydrogen based economy can be a great opportunity for a country like Qatar to decarbonize its multiple sectors including transportation, shipping, global energy markets, and industrial sectors. However, there are still some barriers to the realization of a hydrogen-based economy, which includes large scale hydrogen production cost, infrastructure investments, bulk storage, transport & distribution, safety consideration, and matching supply-demand uncertainties. This paper highlights how the aforementioned challenges can be handled strategically through a multi-sector industrial-urban symbiosis for the hydrogen supply chain implementation. Such symbiosis can enhance the mutual relationship between diverse industries and urban planning by exploring varied scopes of multi-purpose hydrogen usage (i.e., clean energy source as a safer carrier, industrial feedstock and intermittent products, vehicle and shipping fuel, and international energy trading, etc.) both in local and international markets. It enables individual entities and businesses to participate in the physical exchange of materials, by-products, energy, and water, with strategic advantages for all participants. Besides, waste/by-product exchanges, several different kinds of synergies are also possible, such as the sharing of resources and shared facilities. The diversified economic base, regional proximity and the facilitation of rules, strategies and policies may be the key drivers that support the creation of a multi-sector hydrogen supply chain in Qatar.
Determination of the Optimum Excitation Wavelength for the Parathyroid Gland Using a Near-Infrared Camera
Authors: Tabei Isao , Fuke Azusa , Fushimi Astushi , Takeyama Hiroshi
Published: January 2021

When performing thyroid/parathyroid surgery, difficulty detecting the parathyroid gland is a common experience because it is frequently mistaken with surrounding structures, including the thyroid gland, lymph nodes, and fat. To obtain successful surgical results, the auto fluorescent property of the parathyroid gland occurring at 820–830 nm has been used. Intraoperative visualization and detection by fluorescence enable protection of the gland from damage and unintended removal. Use of a near-infrared (NIR) camera has been proposed to indicate the parathyroid gland, but the devices and success rates have varied. This study aimed to define optimum excitation wavelength (EWL) by measuring the EWL of the parathyroid gland for its autofluorescence. Glands were exposed to EWL at 10-nm intervals from 670–790 nm with a light-emitting diode monochromator; autofluorescence intensity was recorded with a conventional NIR video camera. Autofluorescence intensity curves of three normal parathyroid glands were depicted; the optimum EWL was measured as 760–770 nm. Also, the illumination of the surrounding structures were compared at the optimum EWL. The auto fluorescent intensity of the parathyroid gland was 2-fold greater than for surrounding structures. This difference in fluorescence intensity should enable distinction of the parathyroid gland from surrounding structures. The clarification of the optimum EWL can guide refinements of the NIR camera for better surgical outcomes by improving detection of the parathyroid glands. Also, an understanding of optimum EWL should lead to developments for microscopic devices to unravel the still unknown mechanisms of the intrinsic autofluorescence of the parathyroid gland.
Rabbit Carcasses for Use in Feline Diets: Amino Acid Concentrations in Fresh and Frozen Carcasses With and Without Gastrointestinal Tracts
Authors: Owens Tammy J. , Fascetti Andrea J. , Calvert C. Christopher , Larsen Jennifer A.
Published: January 2021

Whole-prey diets for exotic feline species are common, and this practice has also increased in popularity for domestic cats. However, prior analyses of prey indicate possible essential amino acid inadequacy, and dilated cardiomyopathy from taurine deficiency was reported in cats fed whole ground rabbit. Crude protein, body water, and amino acid concentrations were evaluated in fresh and frozen ground rabbits with (n=10) or without (n = 10) gastrointestinal tracts. Amino acids were greater in fresh samples without gastrointestinal tracts (p < 0.05) except taurine, glycine, and cysteine. When normalized for protein content, only glutamate, alanine, methionine, isoleucine, tyrosine, lysine, histidine, and arginine were greater in fresh rabbits without gastrointestinal tracts (g/16 g N basis; p < 0.05). Freezing at −18°C for 30 days had no effect on crude protein or body water content. After freezing, only methionine was lower and only proline was higher when gastrointestinal tracts were omitted (g/16 g N basis; p < 0.05). Regardless, all essential amino acids except taurine exceeded Association of American Feed Control Officials and National Research Council nutrient recommendations for all feline life stages. In contrast, there was minimal impact of treatment on taurine concentrations. However, although feline taurine requirements for prey and other raw or fresh food diets remain undefined, none of the rabbit samples met any recommendation for taurine concentrations for commercial canned or dry extruded diets, ranging from 20 to 90% of the minimum values. Taurine supplementation is recommended when feeding rabbit to cats. Determination of taurine requirements of cats fed whole-prey diets is warranted.
A Peptide-Based Enzyme-Linked Immunosorbent Assay for Detecting Antibodies Against Avian Infectious Bronchitis Virus
Authors: Yin Liping , Wu Qi , Lin Zhixian , Qian Kun , Shao Hongxia , Wan Zhimin , Liu Yuelong , Ye Jianqiang , Qin Aijian
Published: January 2021

Infectious bronchitis virus (IBV) causes substantial loss to the poultry industry despite extensive vaccination. Assessing the antibody response is important for the development and evaluation of effective vaccines. We have developed an enzyme-linked immunosorbent assay (ELISA) for the detection of IBV-specific antibodies, using a synthetic peptide based on a conserved sequence in the IBV spike protein. This peptide-based ELISA (pELISA) specifically detects antibodies to different genotypes of IBV but not antibodies against other common chicken viruses. This assay could detect IBV-specific antibody response on as early as day 7 postinfection. In the testing with field serum samples collected from chickens administered with IBV vaccines, the sensitivity, specificity, and accuracy of pELISA were 98.30, 94.12, and 98.8%, respectively, relative to indirect immunofluorescence assay. Our data demonstrate that the pELISA is of value for the detection of IBV antibody and the evaluation of IBV vaccines.
Nephropathogenic Infectious Bronchitis Virus Infection Altered the Metabolome Profile and Immune Function of the Bursa of Fabricius in Chicken
Authors: Kuang Jun , Xu Puzhi , Shi Yan , Yang Yitian , Liu Ping , Chen Shupeng , Zhou Changming , Li Guyue , Zhuang Yu , Hu Ruiming , Hu Guoliang , Guo Xiaoquan
Published: January 2021

Infectious bronchitis is a highly contagious, acute viral respiratory disease of chickens, regardless of the strain, and its infection may lead to considerable economic losses to the poultry industry. New nephropathogenic infectious bronchitis virus (NIBV) strains have increasingly emerged in recent years; hence, evaluating their infection-influenced immune function changes and the alteration of metabolite profiling is important. Initially, chickens were randomly distributed into two groups: the control group (Con) and the disease group (Dis). Here, the partial cytokines were examined, and the metabolome alterations of the bursa of Fabricius (BF) in NIBV infections in chickens were profiled by gas chromatography time-of-flight/mass spectrometry (GC-TOF/MS). The results revealed that the NIBV infection promotes the mRNA expression of inflammatory cytokines. Metabolic profile analysis indicated that clustering differed between the two groups and there were 75 significantly different metabolites detected between the two groups, suggesting that the host metabolism was significantly changed by NIBV infection. Notably, the following 12 metabolites were identified as the potential biomarkers: 3-phenyllactic acid, 2-deoxytetronic acid, aminomalonic acid, malonamide 5, uric acid, arachidonic acid, 2-methylglutaric acid, linoleic acid, ethanolamine, stearic acid, N-alpha-acetyl-l-ornithine, and O-acetylserine. Furthermore, the results of the correlation analysis showed that a strong correlation existed between metabolic biomarkers and inflammatory cytokines. Our results describe an immune and metabolic profile for the BF of chickens when infected with NIBV and provide new biomarkers of NIBV infection as potential targets and indicators of indicating therapeutic efficacy.
Enhancing the Growth Rate, Biochemical Blood Indices, and Antioxidative Capacity of Broilers by Including Aloe vera Gel in Drinking Water
Authors: Amber Khairy , Nofel Reayd , Ghanem Reda , Sayed Samy , Farag Soha A. , Shukry Mustafa , Dawood Mahmoud A. O.
Published: January 2021

Phytogenic herbal extracts received considerable attention in the broilers industry as friendly alternative substitutes to antibiotics. These additives can be included in the food or drinking water to enhance birds' growth rate and well-being. Hence, the current investigation examined the effect of including Aloe vera gel in drinking water on the growth rate, biochemical blood indices, and broilers' antioxidative capacity. Cobb 500 broiler chicks (n = 120), 1 day old of initial weight = 48.6 ± 1.65 g, were divided into three treatments where the control group was fed the basal diet without including Aloe vera gel in drinking water. The second and third groups were fed the basal diet, and Aloe vera gel was included in drinking water at 1 and 1.5%, respectively. The final body weight, weight gain, daily weight gain, and feed conversion ratio were significantly improved in birds that received drinking water with Aloe vera gel at 1.5% compared to the control and 1% groups (P ≤ 0.05). The kidney (creatinine and urea) and liver (ALT and AST) function indices of broilers that received drinking water with or without Aloe vera gel showed no significant differences with the control group (P ≥ 0.05). The blood total protein and albumin had higher values in birds that received drinking water with 1.5% Aloe vera gel than the control (P ≤ 0.05). The total blood cholesterol, triglycerides, and LDL levels were significantly decreased in the group of birds that received 1.5% Aloe vera gel in drinking water (P ≤ 0.05). The HDL level was higher in birds that received drinking water with 1.5% Aloe vera gel than the control (P ≤ 0.05). The total antioxidative capacity (TAC) and glutathione peroxidase (GPX) showed higher activity in the group of birds that received 1.5% Aloe vera gel while the level of malondialdehyde (MDA) was lower in birds that received drinking water with 1.5% Aloe vera gel than the control (P ≤ 0.05). In summary, including Aloe vera gel in drinking water enhanced the growth rate, biochemical blood indices, and broilers' antioxidative capacity.
A Novel Reduction Circuit Based on Binary Tree Path Partition on FPGAs
Authors: Tang Linhuai , Huang Zhihong , Cai Gang , Zheng Yong , Chen Jiamin
Published: January 2021

Due to high parallelism, field-programmable gate arrays are widely used as accelerators in engineering and scientific fields, which involve a large number of operations of vector and matrix. High-performance accumulation circuits are the key to large-scale matrix operations. By selecting the adder as the reduction operator, the reduction circuit can implement the accumulation function. However, the pipelined adder will bring challenges to the design of the reduction circuit. To solve this problem, we propose a novel reduction circuit based on binary tree path partition, which can simultaneously handle multiple data sets with arbitrary lengths. It divides the input data into multiple groups and sends them to different iterations for calculation. The elements belonging to the same data set in each group are added to obtain a partial result, and the partial results of the same data set are added to achieve the final result. Compared with other reduction methods, it has the least area-time product.
Crop Rotation Enhances Agricultural Sustainability: From an Empirical Evaluation of Eco-Economic Benefits in Rice Production
Authors: He Dun-Chun , Ma Yan-Li , Li Zhuan-Zhuan , Zhong Chang-Sui , Cheng Zhao-Bang , Zhan Jiasui
Published: January 2021

Cropping systems greatly impact the productivity and resilience of agricultural ecosystems. However, we often lack an understanding of the quantitative interactions among social, economic and ecological components in each of the systems, especially with regard to crop rotation. Current production systems cannot guarantee both high profits in the short term and social and ecological benefits in the long term. This study combined statistic and economic models to evaluate the comprehensive effects of cropping systems on rice production using data collected from experimental fields between 2017 and 2018. The results showed that increasing agricultural diversity through rotations, particularly potato–rice rotation (PR), significantly increased the social, economic and ecological benefits of rice production. Yields, profits, profit margins, weighted dimensionless values of soil chemical and physical (SCP) and heavy metal (SHM) traits, benefits and externalities generated by PR and other rotations were generally higher than successive rice cropping. This suggests that agricultural diversity through rotations, particularly PR rotation, is worth implementing due to its overall benefits generated in rice production. However, due to various nutrient residues from preceding crops, fertilizer application should be rationalized to improve the resource and investment efficiency. Furthermore, we internalized the externalities (hidden ecological and social benefits/costs) generated by each of the rotation systems and proposed ways of incenting farmers to adopt crop rotation approaches for sustainable rice production.
Long-Term Yield Variability of Triticale (×Triticosecale Wittmack) Tested Using a CART Model
Authors: Wójcik-Gront Elżbieta , Studnicki Marcin
Published: January 2021

Triticale is a promising food crop that combines the yield potential and grain quality of wheat with the disease and environmental tolerance of rye. The objective of this study was to evaluate the impact of genotype, environment and crop management on spring and winter triticale yield variability, using data from 31 locations across the whole of Poland, from 2009 to 2017, with the Classification and Regression Tree (CART) analysis. It was found that CART is able to detect differences in spring and winter triticale successful growth. The yield variability of spring triticale was more dependent on the soil quality than winter triticale because of a shorter cycle duration, which increases sensitivity to nutrient supply and weather conditions. Spring triticale also needs to be sown as soon as possible to ensure a successful establishment. A strong dependence of yield variability on the availability of water for the winter triticale was observed. When growing winter triticale in Poland, with periodic excess water especially during autumn and early spring, the use of fungicides and growth regulators should be taken into account.
The Effects of Combined Pre and Postharvest Deficit Irrigation on Loquat Yield, Fruit Quality and Handling Aptitude
Authors: Hueso Juan J. , Alonso Francisca , Cañete María L. , González Mónica , Pinillos Virginia , Chiamolera Fernando M. , Cuevas Julián
Published: January 2021

Loquat prices depend on fruit size and earliness. Earliness is improved by postharvest deficit irrigation (DI), without negative effects on fruit size. An optimization of postharvest DI strategies carried out by limiting the dry period led to greater harvest date advancement, but water savings were reduced. To further improve fruit earliness and quality and increase water savings, we combined pre and postharvest DI strategies. Treatments were T1: trees not irrigated during six weeks after harvest (no preharvest DI applied); T2: trees that, in addition to postharvest DI, were not watered from the rapid fruit growth phase to harvest (nine extra weeks of DI); T3: trees that, in addition to postharvest DI, were not watered from color break to harvest (six weeks of DI plus postharvest DI); and T4: trees that in addition to postharvest DI were not watered during rapid fruit growth, but were re-irrigated at color break (2–3 weeks of DI, depending on the season). Full-irrigated trees were grown for comparison. T1 saved 18% water with respect to full-irrigation, and advanced harvesting by 16 days. T2 saved more water, had an earlier harvest and produced a higher early yield. Shorter dry periods were beneficial to a lower extent. Fruit size was significantly diminished by T2, but not by T4. A major advantage of T3 and T4 was the better performance of fruit during handling and shelf life. T2 fruits were favored by panelists for their sweetness but criticized for their smaller size.
Unmanned Aerial Vehicles in Agriculture: A Survey
Authors: del Cerro Jaime , Cruz Ulloa Christyan , Barrientos Antonio , de León Rivas Jorge
Published: January 2021

The number of tasks that nowadays are accomplished by using unmanned aerial vehicles is rising across many civil applications, including agriculture. Thus, this work aims at providing the reader with an overview of the agronomical use of unmanned aerial vehicles. The work starts with a historical analysis of the use of aircrafts in agriculture, as pioneers of their use in modern precision agriculture techniques, currently applied by a high number of users. This survey has been carried out by providing a classification of the vehicles according to their typology and main sensorial and performance features. An extensive review of the most common applications and the advantages of using unmanned aerial vehicles is the core of the work. Finally, a brief summary of the key points of the legislation applicable to civil drones that could affect to agricultural applications is analyzed.
Effects of Zinc and Menthol-Based Diets on Co-Selection of Antibiotic Resistance among E. coli and Enterococcus spp. in Beef Cattle
Authors: Murray Sarah A. , Amachawadi Raghavendra G. , Norman Keri N. , Lawhon Sara D. , Nagaraja Tiruvoor G. , Drouillard James S. , Scott Harvey M.
Published: January 2021

Antibiotic resistance represents a growing crisis in both human and veterinary medicine. We evaluated the use of antibiotic alternatives—heavy metals and essential oils—in beef cattle feeding, and their effects on Gram-negative and Gram-positive bacteria. In this randomized controlled field trial, we measured the impact of supplemental zinc and menthol on antibiotic resistance among commensal enteric bacteria of feeder cattle. Fecal suspensions were plated onto plain- and antibiotic-supplemented MacConkey and m-Enterococcus agar for quantification of total and antibiotic-resistant Escherichia coli and Enterococcus spp., respectively. Temporal effects on overall E. coli growth were significant (p < 0.05), and menthol was associated with decreased growth on tetracycline-supplemented agar. Zinc was associated with significant increases in growth on erythromycin-supplemented m-Enterococcus agar. Cattle fed zinc exhibited significantly higher levels of macrolide resistance among fecal enterococci isolates.
The Effect of Dietary Supplementation with Inorganic or Organic Selenium on the Nutritional Quality and Shelf Life of Goose Meat and Liver
Authors: Nemati Zabihollah , Alirezalu Kazem , Besharati Maghsoud , Holman Benjamin W. B. , Hajipour Mohammadreza , Bohrer Benjamin M.
Published: January 2021

Ninety-six male goslings were allocated and assigned to treatment using a completely randomized design. Dietary treatments included a basal diet consisting of corn, wheat, and soybean meal with either no additional selenium (CON), 0.3 mg/kg of inorganic selenium (I-Se; sodium selenite), or 0.3 mg/kg of organic selenium (O-Se; selenium-enriched yeast). After a 56-day feeding period, geese were slaughtered on a common ending day and two geese per pen (n = 24) were used for the analyses conducted in this study. Meat (equal portions of the breast and thigh meat) and liver were collected and evaluated for proximate composition, fatty acid profile, pH, phenolic content, thiobarbituric acid reactive substances (TBARS), and total volatile basic nitrogen (TVB-N) over a 9-day storage period at 4 °C. The meat and liver samples from geese supplemented I-Se or O-Se had greater (p < 0.01) lipid content compared with geese not supplemented with additional selenium. At the conclusion of the 9-day storage period, meat and liver samples from geese supplemented I-Se or O-Se had lower (p < 0.05) pH values, greater (p < 0.05) phenolic content, lower (p < 0.05) TBARS values, and lower (p < 0.05) TVB-N compared with geese not supplemented with additional selenium (CON).
Effects of Commercial Antioxidants in Feed on Growth Performance and Oxidative Stress Status of Weaned Piglets
Authors: Orengo Juan , Hernández Fuensanta , Martínez-Miró Silvia , Sánchez Cristian Jesús , Peres Rubio Camila , Madrid Josefa
Published: January 2021

This work aimed to evaluate the effect of adding two different commercial antioxidants (AOX) products to pre-starter and starter diets using low vitamin E (Vit E as DL-α-tocopheryl acetate) levels on the growth performance and oxidative stress of piglets for the first six weeks post-weaning (PW). They were sorted by initial body weight (BW: 6.175 ± 0.931 kg) and randomly allotted to four dietary treatments (with six replicates per treatment): a positive control (PC) and a negative control (NC) diet, with normal and low dose of vitamin E (80 and 15 mg kg−1, respectively), both without AOX; the other two experimental diets with a low dose of vitamin E (LVE) plus LOXIDAN VD100 (LVE + AOX1) or LOXIDAN E Ros (LVE + AOX2). Growth data were recorded, and blood samples were taken, at the beginning (day 0) and at the end of each feeding period: pre-starter and starter (at days 14 and 42, respectively). No differences among dietary treatments were found with respect to growth performance in the pre-starter period (p ≥ 0.05). However, at the end of the starter period, a lower BW was found in piglets fed the NC diet compared to the other dietary treatments. Differences in daily gain and feed conversion ratio were also found either for the starter period or when the whole period was considered (p < 0.05), whereby piglets fed PC or LVE diets supplemented with AOX showed better growth performance compared to piglets fed the NC diet. Regarding Vit E (α-tocopherol) serum levels, there were no differences among treatments at day 0; but the serum values of this vitamin decreased in LVE diets at 14 and 42 days, but not in the PC. On day 42, the highest levels of α-tocopherol in liver were also found in piglets fed PC (p < 0.05). Nevertheless, in general, from a metabolic point of view and after checking the serum biochemical profile of piglets, there were no differences in other oxidative stress markers (p ≥ 0.05). The results showed that the AOX products used were able to compensate for the lower Vit E supply with respect to growth performance in the starter phase. The use of AOXs or usual levels of Vit E in feed constitutes a key factor in achieving optimal growth performance of piglets in the PW period.
How N-Acetylcysteine Supplementation Affects Redox Regulation, Especially at Mitohormesis and Sarcohormesis Level: Current Perspective
Authors: Devrim-Lanpir Aslı , Hill Lee , Knechtle Beat
Published: January 2021

Exercise frequently alters the metabolic processes of oxidative metabolism in athletes, including exposure to extreme reactive oxygen species impairing exercise performance. Therefore, both researchers and athletes have been consistently investigating the possible strategies to improve metabolic adaptations to exercise-induced oxidative stress. N-acetylcysteine (NAC) has been applied as a therapeutic agent in treating many diseases in humans due to its precursory role in the production of hepatic glutathione, a natural antioxidant. Several studies have investigated NAC’s possible therapeutic role in oxidative metabolism and adaptive response to exercise in the athletic population. However, still conflicting questions regarding NAC supplementation need to be clarified. This narrative review aims to re-evaluate the metabolic effects of NAC on exercise-induced oxidative stress and adaptive response developed by athletes against the exercise, especially mitohormetic and sarcohormetic response.
Suicidal Erythrocyte Death in Metabolic Syndrome
Authors: Restivo Ignazio , Attanzio Alessandro , Tesoriere Luisa , Allegra Mario
Published: January 2021

Eryptosis is a coordinated, programmed cell death culminating with the disposal of cells without disruption of the cell membrane and the release of endocellular oxidative and pro-inflammatory milieu. While providing a convenient form of death for erythrocytes, dysregulated eryptosis may result in a series of detrimental and harmful pathological consequences highly related to the endothelial dysfunction (ED). Metabolic syndrome (MetS) is described as a cluster of cardiometabolic factors (hyperglycemia, dyslipidemia, hypertension and obesity) that increases the risk of cardiovascular complications such as those related to diabetes and atherosclerosis. In the light of the crucial role exerted by the eryptotic process in the ED, the focus of the present review is to report and discuss the involvement of eryptosis within MetS, where vascular complications are utterly relevant. Current knowledge on the mechanisms leading to eryptosis in MetS-related conditions (hyperglycemia, dyslipidemia, hypertension and obesity) will be analyzed. Moreover, clinical evidence supporting or proposing a role for eryptosis in the ED, associated to MetS cardiovascular complications, will be discussed.
Predictive Migration Performance in Vehicular Edge Computing Environments
Authors: Gilly Katja , Filiposka Sonja , Alcaraz Salvador
Published: January 2021

Advanced learning algorithms for autonomous driving require lots of processing and storage power, which puts a strain on vehicles’ computing resources. Using a combination of 5G network connectivity with ultra-high bandwidth and low latency together with extra computing power located at the edge of the network can help extend the capabilities of vehicular networks. However, due to the high mobility, it is essential that the offloaded services are migrated so that they are always in close proximity to the requester. Using proactive migration techniques ensures minimum latency for high service quality. However, predicting the next edge server to migrate comes with an error that can have deteriorating effects on the latency. In this paper, we examine the influence of mobility prediction errors on edge service migration performances in terms of latency penalty using a large-scale urban vehicular simulation. Our results show that the average service delay increases almost linearly with the migration prediction error, with 20% error yielding almost double service latency.
Kinematic In Situ Self-Calibration of a Backpack-Based Multi-Beam LiDAR System
Authors: Kim Han Sae , Kim Yongil , Kim Changjae , Choi Kang Hyeok
Published: January 2021

Light Detection and Ranging (LiDAR) remote sensing technology provides a more efficient means to acquire accurate 3D information from large-scale environments. Among the variety of LiDAR sensors, Multi-Beam LiDAR (MBL) sensors are one of the most extensively applied scanner types for mobile applications. Despite the efficiency of these sensors, their observation accuracy is relatively low for effective use in mobile mapping applications, which require measurements at a higher level of accuracy. In addition, measurement instability of MBL demonstrates that frequent re-calibration is necessary to maintain a high level of accuracy. Therefore, frequent in situ calibration prior to data acquisition is an essential step in order to meet the accuracy-level requirements and to implement these scanners for precise mobile applications. In this study, kinematic in situ self-calibration of a backpack-based MBL system was investigated to develop an accurate backpack-based mobile mapping system. First, simulated datasets were generated for the experiments and tested in a controlled environment to inspect the minimum network configuration for self-calibration. For this purpose, our own-developed simulator program was first utilized to generate simulation datasets with various observation settings, network configurations, test sites, and targets. Afterwards, self-calibration was carried out using the simulation datasets. Second, real datasets were captured in a kinematic situation so as to compare the calibration results with the simulation experiments. The results demonstrate that the kinematic self-calibration of the backpack-based MBL system could improve the point cloud accuracy with Root Mean Square Error (RMSE) of planar misclosure up to 81%. Conclusively, in situ self-calibration of the backpack-based MBL system can be performed using on-site datasets, reaching the higher accuracy of point cloud. In addition, this method, by performing automatic calibration using the scan data, has the potential to be adapted to on-line re-calibration.
New Retailing Problem for an Integrated Food Supply Chain in the Baking Industry
Authors: Xu Ning , Huang Yung-Fu , Weng Ming-Wei , Do Manh-Hoang
Published: January 2021

As coronavirus disease 2019 (COVID-19) continues to spread, online consumption habits in China have changed significantly. Thus, the booming online-to-offline (O2O) food ordering and delivery industry via the online bakery have been changing customers’ food shopping behavior. This article proposes a comparison relying on advanced O2O strategy for a single-vendor-single-retailer integrated system. Three coordination mechanisms consist of revenue-sharing, buy-back, and quantity flexibility contracts have been employed for optimizing the order quantity. Replenishment strategies and temperature for the supply chain members are considered based on the new retailing framework. Herein, the authors suggest an algorithm for the computation of the optimal solution. Lastly, numerical examples and sensitivity analysis are also conducted to clarify the usefulness of the proposed model in the food supply chain. Sensitivity analysis revealed a number of managerial insights. For example, the results obtained under O2O operations can be compared with those obtained under online/offline operations (under various parameters settings) to determine an opportune moment for three coordination mechanisms.
Implementation of a Cryogenic Facility for Space Debris Analysis
Authors: Gordo Paulo , Frederico Tiago , Melicio Rui , Amorim António
Published: January 2021

This paper has resulted from a continued study of spacecraft material degradation and space debris formation. The design and implementation of a thermal vacuum cycling cryogenic facility for the evaluation of space debris generation at a low Earth orbit (LEO) is presented. The facility used for spacecraft external material evaluation is described, and some of the obtained results are presented. The infrastructure was developed in the framework of a study for the European Space Agency (ESA). The main purpose of the cryogenic facility is to simulate the LEO spacecraft environment, namely thermal cycling and vacuum ultraviolet (VUV) irradiation to simulate the spacecraft material degradation and the generation of space debris. In a previous work, some results under LEO test conditions showed the effectiveness of the cryogenic facility for material evaluation, namely: the degradation of satellite paints with a change in their thermo-optical properties, leading to the emission of cover flakes; the degradation of the pressure-sensitive adhesive (PSA) used to glue Velcro’s to the spacecraft, and to glue multilayer insulation (MLI) to the spacecraft’s. The paint flakes generated are space debris. Hence, in a scenario of space missions where a spacecraft has lost the thermal shielding capability, the failure of PSA tape and the loss of Velcro properties may contribute to the release of the full MLI blanket, contributing to the generation of space debris that presents a growing threat to space missions in the main Earth orbits.
3D Volumetric Analysis and Anatomical Considerations for Sinus Bone Graft
Authors: Kim Ji Hyoung , Kim Hyo Joon , Jo Ye Joon , Choi Jun Seok , Moon Seong Yong
Published: January 2021

The aim of this study is to evaluate anatomical considerations and assess the volume of the maxillary sinus bone graft. There were sixty-three patients (eighty-three sinuses) who had taken CT scans for implant surgery. Patients included those whose height of the residual alveolar bone was less than 5 mm. The position of posterior superior alveolar artery, the thickness of the maxillary sinus wall, and the volume of the maxillary sinus according to the amount of sinus floor elevation were measured. The mean vertical distance of posterior superior alveolar artery was 11.91 ± 4.79 mm from 3.03 mm to 24.05 mm. The mean thickness of the lateral wall was 1.71 ± 0.55 mm in the range of 0.74 mm to 3.93 mm. The volume of 3 mm, 5 mm, 7 mm, and 10 mm from the sinus floor was 0.173 ± 0.11 cm3, 0.526 ± 0.25 cm3, 1.068 ± 0.43 cm3, and 2.184 ± 0.74 cm3 on average, respectively. The knowledge of the posterior superior alveolar artery position, the lateral wall thickness, and the volume of the maxillary sinus can help the clinician for sinus bone graft.
Visual Tracking of Small Unmanned Aerial Vehicles Based on Object Proposal Voting
Authors: Hong Jin , Kwon Junseok
Published: January 2021

In this paper, we propose a novel visual tracking method for unmanned aerial vehicles (UAVs) in aerial scenery. To track the UAVs robustly, we present a new object proposal method that can accurately determine the object regions that are likely to exist. The proposed object proposal method is robust to small objects and severe background clutter. For this, we vote on candidate areas of the object and increase or decrease the weight of the area accordingly. Thus, the method can accurately propose the object areas that can be used to track small-sized UAVs with the assumption that their motion is smooth over time. Experimental results verify that UAVs are accurately tracked even when they are very small and the background is complex. The proposed method qualitatively and quantitatively delivers state-of-the-art performance in comparison with conventional object proposal-based methods.
Long Term Effects of Forest Liming on the Acid-Base Budget
Authors: Greve Martin , Block Joachim , Schüler Gebhard , Werner Willy
Published: January 2021

In Rhineland-Palatinate (Germany), a high percentage of the forest area is located on poor soils with low buffering capacity. Extensive liming applications were performed to compensate for the negative consequences of acid deposition. In 1988, three experimental sites with untreated control plots and different liming treatments were established in coniferous stands to investigate the effectiveness of liming on acidification and its effect on forest ecosystems. Measuring deposition and seepage waters for 24 years allowed for calculating long-term acid-base budgets. The original approach was expanded by data from a detailed sampling of the forest stand and mineral weathering rates. Without liming, the acid load exceeded the buffer capacity by base cation release from silicate weathering during the whole observation period. As a result, there was a high release of aluminum. After liming seepage water output of organic anions, nitrate and sulfate increased in some cases, leading to a higher acid load. However, the carbonates of dolomitic limestone compensated for a higher acid load, resulting in less aluminum released compared to the control plots. Until sulfate output by seepage water declines and nitrogen emissions are reduced, liming and restricted biomass harvesting are required for forest stands on base poor soils to prevent further acidification, decline of nutrient stocks, and the destruction of clay minerals.
Optimized Computation of Tight Focusing of Short Pulses Using Mapping to Periodic Space
Authors: Panova Elena , Volokitin Valentin , Efimenko Evgeny , Ferri Julien , Blackburn Thomas , Marklund Mattias , Muschet Alexander , De Andres Gonzalez Aitor , Fischer Peter , Veisz Laszlo , Meyerov Iosif , Gonoskov Arkady
Published: January 2021

When a pulsed, few-cycle electromagnetic wave is focused by optics with f-number smaller than two, the frequency components it contains are focused to different regions of space, building up a complex electromagnetic field structure. Accurate numerical computation of this structure is essential for many applications such as the analysis, diagnostics, and control of high-intensity laser-matter interactions. However, straightforward use of finite-difference methods can impose unacceptably high demands on computational resources, owing to the necessity of resolving far-field and near-field zones at sufficiently high resolution to overcome numerical dispersion effects. Here, we present a procedure for fast computation of tight focusing by mapping a spherically curved far-field region to periodic space, where the field can be advanced by a dispersion-free spectral solver. In many cases of interest, the mapping reduces both run time and memory requirements by a factor of order 10, making it possible to carry out simulations on a desktop machine or a single node of a supercomputer. We provide an open-source C++ implementation with Python bindings and demonstrate its use for a desktop machine, where the routine provides the opportunity to use the resolution sufficient for handling the pulses with spectra spanning over several octaves. The described approach can facilitate the stability analysis of theoretical proposals, the studies based on statistical inferences, as well as the overall development and analysis of experiments with tightly-focused short laser pulses.
A Novel Graph and Safety Potential Field Theory-Based Vehicle Platoon Formation and Optimization Method
Authors: Li Linheng , Gan Jing , Qu Xu , Mao Peipei , Yi Ziwei , Ran Bin
Published: January 2021

Platooning is considered to be a very effective method for improving traffic efficiency, traffic safety and fuel economy under the connected and automated environment. The prerequisite for realizing these advantages is how to form a platoon without any collisions and how to maintain and optimize the car-following behavior after platoon formation. However, most of the existing studies focus on the platoon configuration and information transmission method, while only a few attempt to address the issue of platoon formation and optimization methods. To this end, this study proposes a novel platoon formation and optimization model combining graph theory and safety potential field (G-SPF) theory for connected and automated vehicles (CAVs) under different vehicle distributions. Compared to previous studies, we innovatively incorporate the concept of the safety potential field to better describe the actual driving risk of vehicles and ensure their absolute safety. A four-step platoon formation and optimization strategy is developed to achieve platoon preliminary formation and platoon driving optimization control. Three traffic scenarios with different CAVs distributions are designed to verify the effectiveness of our proposed platoon formation method based on G-SPF theory, and the simulation results indicate that a collision-free platoon can be formed in a short time. Additionally, the G-SPF-based platoon driving optimization control method is demonstrated by comparing it with two typical control strategies. Compared with the constant spacing and constant time headway control strategies, the simulation results show that our proposed method can improve the traffic capacity by approximately 48.8% and 26.6%, respectively.
CFD-Based Investigation on Effects of Orifice Length–Diameter Ratio for the Design of Hydrostatic Thrust Bearings
Authors: Gao Siyu , Shang Youyun , Gao Qiang , Lu Lihua , Zhu Min , Sun Yan , Yu Weifeng
Published: January 2021

Orifice-restricted hydrostatic thrust bearings are broadly employed in ultra-precision machine tools, aerospace industries, and so forth. The orifice length–diameter ratio (OLDR) is one of the significant geometrical parameters of the orifice-restricted hydrostatic thrust bearing, which directly affects the performance of the bearing. To accurately guide the design of the hydrostatic thrust bearing, the effect of the OLDR on the performance of the hydrostatic thrust bearing needs to be thoroughly and scientifically investigated, especially for ultra-precision machine tools. In this paper, the influences of various OLDRs are comprehensively studied using the computational fluid dynamics (CFD) approach on the pressure pattern, velocity, turbulent intensity, and vortices, as well as the load capacity, stiffness, volume flow rate, and orifice flow resistance of the hydrostatic thrust bearing under identical operating conditions. The obtained results show that there are differences in performance behaviors of the hydrostatic thrust bearing caused by different OLDRs. Some new findings are obtained, particularly in the second-order small vortices which appear in the annular recesses with all OLDRs except that of 2, and the flow resistance does not always increase with increasing OLDRs. Finally, the proposed CFD approach is experimentally validated.
Driving Force Distribution and Control for Maneuverability and Stability of a 6WD Skid-Steering EUGV with Independent Drive Motors
Authors: Zhang Hui , Liang Huawei , Tao Xiang , Ding Yi , Yu Biao , Bai Rengui
Published: January 2021

In this paper, a hierarchical driving force distribution and control strategy for a six-wheel drive (6WD) skid-steering electric unmanned ground vehicle (EUGV) with independent drive motors is presented to improve the vehicle maneuverability and stability. The proposed hierarchical strategy is based on a nine-degrees-of-freedom (DOFs) dynamics model of 6WD skid-steering EUGV with a vehicle system dynamics model, wheel dynamics model, and tire model. In the proposed hierarchical strategy, the upper layer controller calculates the resultant driving force and yaw moment to control the vehicle motion states to track the desired ones by using the integral sliding mode control (ISMC) and proportion–integral–differential (PID) control methods. In the lower layer controllers, the driving force distribution method is adopted to allocate torques to the six motors. An objective function is proposed and composed of the longitudinal tire workload rates and weighting factors, considering the inequality constraints and equality constraints, which is solved by using the active set method. In order to evaluate the effectiveness of the proposed method, experiments with two types of scenarios were conducted. Comparative studies were also conducted with the other two methods used in the literature. The experimental results show that better performance can be achieved with the proposed control strategy in vehicle maneuverability and stability.