bluuebunny/crossref_metadata_2025 huggingface dataset:
Lights, Headset, Tablet, Action: Exploring the Use of Hybrid User Interfaces for Immersive Situated Analytics
Authors: Zhou Xiaoyan , Lee Benjamin , Ortega Francisco R. , Batmaz Anil Ufuk , Yang Yalong
Published: October 2024

While augmented reality (AR) headsets provide entirely new ways of seeing and interacting with data, traditional computing devices can play a symbiotic role when used in conjunction with AR as a hybrid user interface. A promising use case for this setup is situated analytics. AR can provide embedded views that are integrated with their physical referents, and a separate device such as a tablet can provide a familiar situated overview of the entire dataset being examined. While prior work has explored similar setups, we sought to understand how people perceive and make use of visualizations presented on both embedded visualizations (in AR) and situated visualizations (on a tablet) to achieve their own goals. To this end, we conducted an exploratory study using a scenario and task familiar to most: adjusting light levels in a smart home based on personal preference and energy usage. In a prototype that simulates AR in virtual reality, embedded visualizations are positioned next to lights distributed across an apartment, and situated visualizations are provided on a handheld tablet. We observed and interviewed 19 participants using the prototype. Participants were easily able to perform the task, though the extent the visualizations were used during the task varied, with some making decisions based on the data and others only on their own preferences. Our findings also suggest the two distinct roles that situated and embedded visualizations can have, and how this clear separation might improve user satisfaction and minimize attention-switching overheads in this hybrid user interface setup. We conclude by discussing the importance of considering the user's needs, goals, and the physical environment for designing and evaluating effective situated analytics applications.
There Is More to Avatars Than Visuals: Investigating Combinations of Visual and Auditory User Representations for Remote Collaboration in Augmented Reality
Authors: Fink Daniel Immanuel , Skowronski Moritz , Zagermann Johannes , Reinschluessel Anke Verena , Reiterer Harald , Feuchtner Tiare
Published: October 2024

Supporting remote collaboration through augmented reality facilitates the experience of co-presence by presenting the collaborator’s avatar in the user’s physical environment. While visual user representations are continuously researched and advanced, the audio configuration – especially in combination with different visualizations – is rarely considered. In a user study (n = 48, 24 dyads), we evaluate the combination of two visual (Simple vs. Rich Avatar) with two auditory (Mono vs. Spatial Audio) user representations, to investigate their impact on user’s overall experience, performance, and perceived social presence during collaboration. Our results show a preference for rich auditory and visual user representations, as Spatial Audio supports completion of parallel tasks and the Rich Avatar positively influence user experience. However, the Simple Avatar draws less attention, which potentially benefits task efficiency, advocating for simpler visualizations in performance-oriented settings. Our findings contribute to a deeper understanding of how visual and auditory user representation combinations impact remote collaboration in augmented reality.
Zooming In: A Review of Designing for Photo Taking in Human-Computer Interaction and Future Prospects
Authors: Wysokińska Aleksandra , Strömel Konstantin R. , Woźniak Paweł W.
Published: October 2024

Photography has been pivotal in culture for decades and its importance has increased with the rise of digital technology. However, the exploration of picture taking within the Human-Computer Interaction (HCI) community does not seem to match its cultural and technological significance. Recognizing this discrepancy, we sought to understand areas of interest in photography as a conscious creative process. To address this issue, we performed a systematic literature review using the PRISMA methodology. From our research, we identified 62 pertinent papers spanning from 2005 to 2022. Our examination revealed six primary dimensions, further classified into study type, design goal, photo-taking style, device type, interaction style, and number of users. In-depth analysis showed the dominant role of exploratory and functional research, the balance between qualitative and quantitative methods, and a strong focus on smartphone cameras. Our review has highlighted significant gaps in the existing literature, offering valuable insights for future research on photo taking.
Audio-Vibratory You-Are-Here Mobile Maps for People with Visual Impairments
Authors: Sargsyan Elen , Oriola Bernard , Serrano Marcos , Jouffrais Christophe
Published: October 2024

Self-localization and wayfinding are challenging tasks for people with visual impairments (PVIs), severely impacting independent mobility. Visual “You-are-here” (YAH) maps are useful for assisting local wayfinding of sighted users. They are used to self-localize and display points of interest, landmarks and routes in the surroundings. However, these maps are not always available and rarely accessible to PVIs. Relying on an iterative participatory design process with eight end-users with visual impairments, we created a proof of concept of a mobile audio-vibratory YAH map. Our design is based on either a tablet or a smartphone to ensure a small and portable solution. A user study with ten PVIs showed that the audio-vibratory YAH map that we designed provides the user with a good understanding of the surroundings and wayfinding cues. Surprisingly, the results show that the audio-vibratory YAH map prototype was as usable as the control condition (audio-tactile YAH map with a tactile overlay), with similar user satisfaction and cognitive load. A follow-up field study with two participants showed the effectiveness of the prototype for assisting in crossroad understanding. To conclude, our innovative design of a mobile audio-vibratory YAH map can overcome the portability and printing issues associated with tactile overlays and can be an appropriate solution for assisting the pedestrian navigation of PVIs.
Hapstick-Figure: Investigating the Design of a Haptic Representation of Human Gestures from Theater Performances for Blind and Visually-Impaired People
Authors: Benhamida Leyla , Larabi Slimane , Metatla Oussama
Published: October 2024

Theaters serve as platforms that transport audiences into diverse worlds, offering a collective enjoyment of live performances and a shared cultural experience. However, theater performances have strong visual components, such as physical props and actors’ movements and gestures, which are inaccessible to visually impaired and blind audience members and thus can exclude them from such shared social experiences. We conducted formative interviews with eight blind and visually impaired people about their experiences with barriers to theater performance gestures. We then present Hapstick-Figure, a prototype design to represent and communicate human gestures via a 3D-printed tactile surface. Next, we used Hapstick-Figure as a technology probe in a qualitative evaluation with six of our BVI participants to explore non-visual interpretation and engagement with this prototype. We outline insights into the haptic representation of theater performance gestures and reflections on designing for accessibility in this context.
Algorithm 1051: UltimateKalman, Flexible Kalman Filtering and Smoothing Using Orthogonal Transformations
Authors: Toledo Sivan
Published: October 2024

UltimateKalman is a flexible linear Kalman filter and smoother implemented in three popular programming languages: MATLAB, C, and Java. UltimateKalman is a slight simplification and slight generalization of an elegant Kalman filter and smoother that was proposed in 1977 by Paige and Saunders. Their algorithm appears to be numerically superior and more flexible than other Kalman filters and smoothers, but curiously has never been implemented or used before. UltimateKalman is flexible: it can easily handle time-dependent problems, problems with state vectors whose dimensions vary from step to step, problems with varying numbers of observations in different steps (or no observations at all in some steps), and problems in which the expectation of the initial state is unknown. The programming interface of UltimateKalman is broken into simple building blocks that can be used to construct filters, single or multi-step predictors, multi-step or whole-track smoothers, and combinations. The article describes the algorithm and its implementation as well as a test suite of examples and tests.
Optimizing Privacy, Utility, and Efficiency in a Constrained Multi-Objective Federated Learning Framework
Authors: Kang Yan , Gu Hanlin , Tang Xingxing , He Yuanqin , Zhang Yuzhu , He Jinnan , Han Yuxing , Fan Lixin , Chen Kai , Yang Qiang
Published: October 2024

Conventionally, federated learning aims to optimize a single objective, typically the utility. However, for a federated learning system to be trustworthy, it needs to simultaneously satisfy multiple objectives, such as maximizing model performance, minimizing privacy leakage and training costs, and being robust to malicious attacks. Multi-Objective Optimization (MOO) aiming to optimize multiple conflicting objectives simultaneously is quite suitable for solving the optimization problem of Trustworthy Federated Learning (TFL). In this article, we unify MOO and TFL by formulating the problem of constrained multi-objective federated learning (CMOFL). Under this formulation, existing MOO algorithms can be adapted to TFL straightforwardly. Different from existing CMOFL algorithms focusing on utility, efficiency, fairness, and robustness, we consider optimizing privacy leakage along with utility loss and training cost, the three primary objectives of a TFL system. We develop two improved CMOFL algorithms based on NSGA-II and PSL, respectively, to effectively and efficiently find Pareto optimal solutions and provide theoretical analysis on their convergence. We design quantitative measurements of privacy leakage, utility loss, and training cost for three privacy protection mechanisms: Randomization, BatchCrypt (an efficient homomorphic encryption), and Sparsification. Empirical experiments conducted under the three protection mechanisms demonstrate the effectiveness of our proposed algorithms.
Discard Significant Bits of Compressed Sensing: A Robust Image Coding for Resource-Limited Contexts
Authors: Chen Zan , Wang Tao , Li Jun , Guo Wenlong , Feng Yuanjing , Qian Xueming , Hou Xingsong
Published: October 2024

Compressed sensing (CS) provides a robust and simple framework for compressing images in resource-constrained environments. However, CS-based image coding schemes often have poor rate-distortion (R-D) performance, particularly due to the quantization process. Our research indicates that leveraging the image prior enables the estimation of most significant bits (MSBs) from least significant bits (LSBs), which provides a quantization strategy to improve R-D performance without increasing coding complexity. That is discarding MSBs of measurements, and only transmitting LSBs to the decoder side. At the decoder side, we reconstruct images by solving an inverse-quantization set-constrained CS optimization problem. Our approach further employs a tailored designed deep denoiser as the proximal operator to enhance the reconstructed image quality. Extensive experimental results demonstrate that the proposed scheme achieves satisfactory performance, with promising R-D results (PSNR gains over 1.71 dB than JPEG at 0.50 bpp compression ratio), and robust bit error and loss resilience (reconstructed 29.98 dB even with 50% bit loss at 0.50 bpp compression ratio), meanwhile having lower encoding complexity (less than half encoding time of CCSDS-IDC).
Imaging of the Inferior Mesenteric Vasculature
Authors: Shetty Anup S. , Fraum Tyler J. , Ludwig Daniel R. , Itani Malak , Rajput Mohamed Z. , Strnad Benjamin S. , Konstantinoff Katerina S. , Chang Andrew L. , Kapoor Suraj , Parwal Utkarsh , Balfe Dennis M. , Mellnick Vincent M.
Published: October 2024

The inferior mesenteric artery and inferior mesenteric vein can be evaluated at CT of the abdomen and pelvis, are important sources of disease, provide collateral pathways to mitigate the effects of various vascular conditions, and yield potentially useful diagnostic clues.
Atypical Presentation of Tertiary Syphilis
Authors: Cholley Paul , Stievenart Julien , Fayard Damien , Cassagnes Lucie
Published: October 2024

Syphilis is a sexually transmitted infection characterized by multiple stages. Cardiovascular involvement is a manifestation of tertiary syphilis, occurring between 10 and 40 years after the primary infection. The authors present a case of atypical presentation of tertiary syphilis in a 49-year-old male patient who was admitted to the hospital with bilateral transient loss of vision. Contrast-enhanced CT imaging revealed thoracic aortitis with carotid occlusion, coronary artery stenosis, ischemic stroke, myocardial infarction, and multiple intracardiac thrombi. A postmortem autopsy revealed positive laboratory results for syphilis, which was corroborated by medical autopsy findings of syphilitic aortitis.

Keywords: CT-Angiography, Aorta, Cardiac, Vascular, Tertiary Syphilis

© RSNA, 2024
Incremental Prognostic Value of Cardiac MRI Feature Tracking and T1 Mapping in Arrhythmogenic Right Ventricular Cardiomyopathy
Authors: Lu Guanyu , Cao Liqi , Ye Weitao , Wei Xiaoyu , Xie Jiajun , Du Zhicheng , Zhang Xinyue , Luo Xinyi , Ou Jiehao , Zhang Qianhuan , Liu Yang , Yang Yuelong , Liu Hui
Published: October 2024

Cardiac MRI biventricular global longitudinal peak strain and extracellular volume fraction provided incremental value for predicting sustained ventricular arrhythmias beyond arrhythmogenic right ventricular cardiomyopathy (ARVC) risk score alone in patients with ARVC.
Impactful Cardiac CT and MRI Articles from 2023
Authors: Coughlan Fionn , Flynn Sebastian , Haenel Alexander , Crilly Shane , Leipsic Jonathon A. , Dodd Jonathan D.
Published: October 2024

This review explores 2023's most impactful cardiac CT and MRI studies for the evaluation of cardiovascular disease.
The FSGS protein actinin-4 interacts with NKCC2 to regulate thick ascending limb NaCl reabsorption
Authors: Maskey Dipak , Liao Tang-Dong , Potter D’Anna L. , Ortiz Pablo A.
Published: October 2024

ACTN4 function and dysfunction in glomerular podocytes have been extensively studied. However, the function of ACTN4 in the nephron has not been studied. Our paper shows for the first time that ACTN4, in the nephron, regulates NaCl reabsorption in part by affecting NKCC2 surface expression. Protein-protein interactions between ACTN4 and NKCC2 seem to mediate NKCC2 endocytosis in TALs. When ACTN4 was silenced in the TAL in vivo using CRISPR/Cas9 or shRNAs, surface NKCC2 and NaCl reabsorption increased.
Screening of Diabetes‐Associated Autoantigens and Serum Antibody Profiles Using a Phage Display System
Authors: Lin Jun , Wang Zhenyu , Wang Hongtao , Li Yuping , Liu Yao , He Yige , Liu Qian , Chen Zichuan , Ji Yuan
Published: October 2024

Aims/Introduction: Phage display method is a crucial tool to find novel clinically valuable diabetes‐associated autoantigens and identify known autoantigen epitopes that are associated with diabetes and could provide scientific support and guidance for the artificial construction and synthesis of Type I diabetes mellitus (T1DM) novel biomarkers.

Materials and Methods: The phage display system was used for the “biopanning” of T1DM serum. Following the sequencing of the phage DNAs, the homologous sequences of the above fusion heptapeptide were further investigated by BLAST to track the origin of the polypeptide sequences. The antibody spectrum revealed new T1DM‐associated epitopes and antibodies.

Results: A total of 1200 phage DNA were sequenced and 9 conserved polypeptide sequences were collected. It was confirmed that the zinc transporter and islet amyloid protease were among them. The conserved polypeptide sequence 8 and another three distinctive polypeptide sequences derived from Proteus were discovered. Furthermore, we expressed recombinant proteins with homologous polypeptide sequences for the human islet amyloid polypeptide (IAPP) and polypeptide precursor human zinc transporter 8 (ZNT8). Through clinical sample detection for the serum from T1DM (n = 100) and T2DM (n = 200) patients, results demonstrate the importance and relevance of these polypeptides in the recognition and classification of various forms of diabetes.

Conclusion: Human pancreatic and concurrent bacterial‐derived protein antigens and their epitopes were identified in this research by the phage display system, which is crucial for distinguishing different types of diabetes.
Animal Wellness: The Power of Multiomics and Integrative Strategies
Authors: Choudhary Ratan Kumar , Kumar B. V. Sunil , Sekhar Mukhopadhyay Chandra , Kashyap Neeraj , Sharma Vishal , Singh Nisha , Salajegheh Tazerji Sina , Kalantari Roozbeh , Hajipour Pouneh , Singh Malik Yashpal
Published: October 2024

The livestock industry faces significant challenges, with disease outbreaks being a particularly devastating issue. These diseases can disrupt the food supply chain and the livelihoods of those involved in the sector. To address this, there is a growing need to enhance the health and well‐being of livestock animals, ultimately improving their performance while minimizing their environmental impact. To tackle the considerable challenge posed by disease epidemics, multiomics approaches offer an excellent opportunity for scientists, breeders, and policymakers to gain a comprehensive understanding of animal biology, pathogens, and their genetic makeup. This understanding is crucial for enhancing the health of livestock animals. Multiomic approaches, including phenomics, genomics, epigenomics, metabolomics, proteomics, transcriptomics, microbiomics, and metaproteomics, are widely employed to assess and enhance animal health. High‐throughput phenotypic data collection allows for the measurement of various fitness traits, both discrete and continuous, which, when mathematically combined, define the overall health and resilience of animals, including their ability to withstand diseases. Omics methods are routinely used to identify genes involved in host‐pathogen interactions, assess fitness traits, and pinpoint animals with disease resistance. Genome‐wide association studies (GWAS) help identify the genetic factors associated with health status, heat stress tolerance, disease resistance, and other health‐related characteristics, including the estimation of breeding value. Furthermore, the interaction between hosts and pathogens, as observed through the assessment of host gut microbiota, plays a crucial role in shaping animal health and, consequently, their performance. Integrating and analyzing various heterogeneous datasets to gain deeper insights into biological systems is a challenging task that necessitates the use of innovative tools. Initiatives like MiBiOmics, which facilitate the visualization, analysis, integration, and exploration of multiomics data, are expected to improve prediction accuracy and identify robust biomarkers linked to animal health. In this review, we discuss the details of multiomics concerning the health and well‐being of livestock animals.
Herbal Agents Against Dermatophytes: Effect of 43 Herbal Agents on Dermatophyte Growth
Authors: Albrecht Johanna , Köberle Martin , Preis Sarah , Biedermann Tilo , Seidl Hans Peter , Lindner Michèle , Florig Ellen , Zink Alexander
Published: October 2024

Dermatophyte infections of the skin and nails are frequent, but current antimycotics have several drawbacks. In search of new treatments, we looked into the vast array of herbal active agents. Derived from plants, they are sustainable, agreeable for patients, and may have less side effects than traditional antimycotics. In this study, we assessed 43 herbal agents for their effectiveness against Trichophyton rubrum (T. rubrum), Trichophyton benhamiae (T. benhamiae), Trichophyton tonsurans (T. tonsurans), and Microsporum canis (M. canis), four major human dermatophyte pathogens. The antifungal effect was tested by incorporating the agents into agar plates and measuring the dermatophyte growth after 7 days. Against T. rubrum, 16 out of 43 herbal agents showed total inhibition of dermatophyte growth. 14 out of 43 herbal agents inhibited the growth of T. benhamiae completely. 18 out of 43 herbal agents were effective against T. tonsurans. Against M. canis, 15 out of 43 herbal agents showed total growth inhibition. Twelve herbal agents inhibited the growth of all tested dermatophytes completely. This study demonstrates the high antimycotic potential of herbal therapeutics and identified promising candidates for the topical treatment of dermatomycoses. Substances are highly agreeable and should be tolerated well. Some might even provide new options for the systemic treatment of fungal diseases.
Development of BIM‐Based Tunnel Information Modeling Prototype for Tunnel Design
Authors: Muhammad Waleed Qazi , Azfar Khan Rai Waqas , Sharafat Abubakar , Arshad Tanoli Waqas , Zubair Muhammad Umer , Qureshi Hisham Jahangir
Published: October 2024

Designing and modeling tunnels are a complex and labor‐intensive process, exacerbated by the involvement of multiple designers and software applications to accommodate diverse geometric and subsurface conditions. This often results in reduced efficiency, productivity, and increased potential for errors. To address these challenges, the authors implemented a strategy integrating building information modeling and mathematical relationships governing tunnel geometries and rock support elements. Using Autodesk Revit, they developed a prototype that allows designers to model tunnels aligned with ground conditions without reliance on multiple software applications. This streamlined approach enhances productivity, simplifies complexities, and improves accuracy in tunnel design and review processes, including quantity take‐offs. A case study comparing the prototype with conventional methods demonstrated significant improvements in efficiency, productivity, and design accuracy. This research offers practical benefits to stakeholders in tunnel projects, optimizing work quality, and outcomes in tunnel design and construction.
Growth Performance, Immune Characteristics, and Health and Welfare of Gilthead Seabream (Sparus aurata) Fed a Tailor‐Made Environmentally Sustainable Diet Formulated Using Novel Ingredients
Authors: Alfonso Sébastien , Toomey Lola , Fiocchi Eleonora , Manfrin Amedeo , Boscarato Marilena , Vasilaki Phelly , Zupa Walter , Bertazzo Valentina , Bégout Marie-Laure , Spedicato Maria Teresa , Mente Elena , Nengas Ioannis , Lembo Giuseppe , Carbonara Pierluigi
Published: October 2024

The use of fish meal/oil in carnivorous fish feeds remains a concern for the environmental sustainability of aquaculture. In this study, we investigated the impact of an innovative diet designed to be cost‐effective and environmentally sustainable (i.e., 60% replacement of fish meal by a blend of plant, yeast [Saccharomyces cerevisiae], and krill meal feed ingredients) on the growth, health, and welfare of gilthead seabream (Sparus aurata). Over a 135‐day experiment, fish were fed either the innovative or a commercial diet (control), and various parameters were evaluated, namely growth performance, levels of physiological blood parameters related to stress, immunity, health, and welfare, as well as swimming activity, serving as a proxy for energy expenditure. Results revealed that the innovative diet enhanced growth compared to fish fed the control diet. Hematological and biochemical indicators did not highlight any impaired welfare condition in fish fed innovative diet while higher levels of Immunoglobulin M were measured in plasma of fish fed innovative diet, potentially suggesting enhancement of humoral immunity. However, accelerometer tags data revealed that fish fed the innovative diet exhibited higher overall swimming activity, suggesting higher energy expenditure, which was consistent with greater prealbumin levels measured in the plasma. In conclusion, the higher energy metabolism in fish fed the innovative diet might be compensated by the diet’s content, which may boost humoral immunity and hence help the fish develop a better adaptation to rearing environment, including its viral and bacterial load, ensuring overall better growth. Longer term investigations, including measurements of additional parameters, are required to validate these promising preliminary outcomes.
Comparison of Histological, Clinical, and Radiographic Outcomes of Postextraction Ridge Preservation by Allogenic Bone Grafting With and Without Injectable Platelet‐Rich Fibrin: A Double‐Blinded Randomized Controlled Clinical Trial
Authors: Talebi Ardakani Mohammad Reza , Rezaei Esfahrood Zeinab , Mashhadiabbas Fatemeh , Hatami Masoud
Published: October 2024

Objectives: This randomized controlled clinical trial compared the histological, clinical, and radiographic outcomes of postextraction ridge preservation by allogenic bone grafting with and without injectable platelet‐rich fibrin (I‐PRF).

Materials and Methods: Twenty single‐rooted maxillary and mandibular teeth to be extracted and replaced by dental implants were randomly divided into two groups (n = 10). Cone‐beam computed tomography (CBCT) scans were obtained preoperatively to assess bone dimensions and ridge width. The teeth were then extracted, and tooth socket preservation was performed with allograft and collagen type 1 in the control group and allograft, collagen type 1, and I‐PRF in the intervention group. CBCT scans were obtained again 3 months after the first stage of surgery, and the second stage of surgery was performed for implant placement, ridge width measurement, and obtaining a biopsy sample. Radiographic bone width, clinical bone width, and radiographic bone height were measured. A histomorphometric method was applied to quantify residual graft material, new bone formation, and nonmineralized tissues. The data were analyzed with Student’s t‐test and Mann–Whitney U test (α = 0.05).

Results: The intervention group showed a significantly smaller reduction in radiographic bone width (P = 0.038) and clinical bone width (P = 0.033), reduction in radiographic bone height (P = 0.213) was not significant. A significantly lower percentage of residual graft particles (P = 0.021) and a significantly higher mean percentage of newly formed bone (P = 0.038) than the control group. However, the difference in the percentage of nonmineralized tissue (P = 0.208) was not significant.

Conclusion: Despite the optimal outcome of ridge preservation in both groups, the application of allograft plus I‐PRF yielded superior histological, clinical, and radiographic results compared with allograft alone, and this difference was significant in most variables.
Efficient Removal of Brilliant Green Dye Using Mesoporous Attapulgite Clay: Investigating Adsorption Kinetics, Isotherms, and Mechanisms
Authors: Al-Jaafari Amal Khudair , AL-Kazragi Muna Abd Ul Rasool
Published: October 2024

The study involved the effectiveness of Iraqi attapulgite (IQATP) clay as an environmentally friendly material that easily adsorbs brilliant green (BG) dye from water systems and is identified by various complementary methods (e.g., FTIR, SEM‐EDS, XRD, ICP‐OES, pHpzc, and BET), where the result reported that the IQATP specific surface area is 29.15 m2/g. A systematic analysis was selected to evaluate the impact of different effective adsorption performance variables on BG dye decontamination. These variables included IQATP dosage (0.02–0.8 g/L), solution pH (3.05–8.15), contact time (ranging from 2 to 25 min), and initial BG dye concentration from 20 to 80 mg/L. The parameters of kinetic profiles were best represented by the (P‐2‐O) model with the determination of coefficient (R2, 0.99), and the corresponding equilibrium data of dye provided a good fit of the Freundlich adsorption model with a maximal multilayer IQATP adsorption capacity (Qmax, = 1.41 mg/g) under optimum conditions (temperature 318 K, pH 3.05, optimum equilibrium time 25 min, and IQATP dosage 0.2 g/L) for BG dye removal. Thermodynamic parameters, including ΔG = −5.67, −6.10, and −7.56 kJ/mol, ΔH = 29.89 kJ/mol, ΔS = 118.73 J/mol·K, and activation energy Ea = 14.38 kJ/mol, were calculated to understand the adsorption process. This trend indicates an endothermic, spontaneous, and favorable adsorption profile for basic dye by IQATP. The adsorption mechanism was elucidated, indicating the involvement of electrostatic attractions, hydrogen bonding, and n − π interactions in the adsorption of cationic dye. Desorption experiments of BG by IQATP with five repetition cycles showed a great desorption percentage when using 0.1 M hydrochloric acid (HCl), as the eluting agent. Overall, the findings highlight IQATP as a promising and desirable natural adsorbent for the efficient removal of cationic dyes.
Supplementary Table S1 from Prostate Cancer Progression Modeling Provides Insight into Dynamic Molecular Changes Associated with Progressive Disease States
Authors: Chen Runpu , Tang Li , Melendy Thomas , Yang Le , Goodison Steve , Sun Yijun
Published: October 2024

Data, methods and softwares used.
Data from Prostate Cancer Progression Modeling Provides Insight into Dynamic Molecular Changes Associated with Progressive Disease States
Authors: Chen Runpu , Tang Li , Melendy Thomas , Yang Le , Goodison Steve , Sun Yijun
Published: October 2024

Abstract
Prostate cancer is a significant health concern and the most commonly diagnosed cancer in men worldwide. Understanding the complex process of prostate tumor evolution and progression is crucial for improved diagnosis, treatments, and patient outcomes. Previous studies have focused on unraveling the dynamics of prostate cancer evolution using phylogenetic or lineage analysis approaches. However, those approaches have limitations in capturing the complete disease process or incorporating genomic and transcriptomic variations comprehensively. In this study, we applied a novel computational approach to derive a prostate cancer progression model using multidimensional data from 497 prostate tumor samples and 52 tumor-adjacent normal samples obtained from The Cancer Genome Atlas study. The model was validated using data from an independent cohort of 545 primary tumor samples. By integrating transcriptomic and genomic data, our model provides a comprehensive view of prostate tumor progression, identifies crucial signaling pathways and genetic events, and uncovers distinct transcription signatures associated with disease progression. Our findings have significant implications for cancer research and hold promise for guiding personalized treatment strategies in prostate cancer.
Significance:
We developed and validated a progression model of prostate cancer using >1,000 tumor and normal tissue samples. The model provided a comprehensive view of prostate tumor evolution and progression.
Analysis of Chromosome Test Results of 24,175 Miscarried Fetuses in Japan from 2000 to 2021
Authors: Takaki Haruyoshi , Kitagawa Rie , Takano Takako
Published: October 2024

Background: Fetal chromosome abnormalities, the most common cause of spontaneous abortion, were investigated pre-1980s. In recent years, chromosome testing has been outsourced to testing companies in Japan, and there have been few epidemiological studies of chromosome testing of miscarried fetuses on a nationwide scale. Methods: We analyzed the chromosome test data of SRL Inc., one of the largest clinical laboratories that has collected tissue specimens of products of conception derived from miscarried fetuses from hospitals throughout Japan from 2000 to 2021. Results: We collected and analyzed 24,175 cases, among which 8,726 (36.1%) with normal chromosomes, 1,298 (5.4%) with sex chromosome aberrations, 9,735 (40.3%) with autosomal trisomy, 73 (0.3%) with autosomal monosomy, 840 (3.5%) with polyploidy, 512 (2.1%) with chromosomal structural abnormality, and 2,991 (12.4%) with mosaic, respectively. The frequency of autosomal trisomy increased at the older maternal ages. By chromosome number, trisomies 22, 16, 21, and 15 were associated with advanced maternal age, but trisomies 13, 14, and 18 were not associated with advanced maternal age. The presence or absence of this maternal age effect was correlated with the chromosome segregation being due to maternal meiosis I or meiosis II. For the sex ratios of the fetuses, we focused on trisomies 22, 21, 18, 16, 15, 14, and 13 and found that only trisomy 16 was significantly more frequently seen in female fetuses. Conclusion: The findings of this study provide insights into the basic understanding of miscarriage and will be useful in counseling and medical education.
Clinical Outcomes of Double-Kissing Crush or Double-Kissing Culotte in Nonleft Main Bifurcation Lesions: The ROUTE Trial
Authors: Kahraman Serkan , Cizgici Ahmet Y. , Guner Ahmet , Tasbulak Omer , Panc Cafer , Dogan Arda C. , Ulutas Ahmet E. , Gurbak Ismail , Bulut Umit , Avci Yalcin , Demir Ali R. , Yalcin Ahmet A. , Kalkan Ali K. , Erturk Mehmet
Published: October 2024

BACKGROUND:

Double-kissing (DK) crush and DK culotte are the recommended 2-stent strategies in true coronary bifurcation lesions. However, it is a matter of curiosity about which of the DK crush and DK culotte stenting techniques will have superior results. We aimed to compare the clinical outcomes of DK crush and DK culotte stenting in nonleft main coronary artery bifurcation.

METHODS:

Consecutive patients who received DK crush or DK culotte technique for de novo true nonleft main coronary artery bifurcation lesion were categorized according to which treatment they received. The primary end point of the study was target lesion failure as a composite end point of target lesion revascularization, target vessel myocardial infarction, and cardiac death. Secondary end points were all-cause death and definite stent thrombosis.

RESULTS:

A total of 202 patients were categorized as DK crush (101 patients) or DK culotte (101 patients) techniques. The target lesion failure had occurred frequently in the DK crush (10.9%) compared with the DK culotte (3.0%;
P
=0.028) that was mainly driven by increased target lesion revascularization (9.9% in the DK crush versus 3.0% in the DK culotte;
P
=0.045). The number of patients with target vessel myocardial infarction (3.0% in the DK crush versus 2.0% in the DK culotte;
P
=0.651) and cardiac death (1.0% in the DK crush versus 0.0% in the DK culotte;
P
=0.315) was higher in the DK crush. There were no differences in terms of definite stent thrombosis and all-cause death between groups.

CONCLUSIONS:

In the present analysis, DK culotte was associated with lower 1-year target lesion failure rates compared with DK crush in true nonleft main coronary artery bifurcations.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT04789161.
Participant Diversity in Stroke‐Related Medical Device Trials: Historical Context and Ongoing Challenges
Authors: Fuhlbrigge Mary E. , Carroll John D. , Gonzales Nicole R. , Orjuela Karen D.
Published: October 2024

Despite an acknowledgment of the ethical and clinical importance of recruiting diverse populations into clinical trials, there is a continued underenrollment of patients with diverse demographic characteristics within the field of neurology and more specifically, in stroke‐related device trials. Efforts on the part of the US Congress, the National Institutes of Health, the US Food and Drug Administration, and the Centers for Medicare & Medicaid Services over the past several decades have attempted to increase trial participant diversity with varying success. This historical context provides an important lens for analyzing diversity proposals and their bearing on device trials in the field of stroke neurology. Despite economic and logistical challenges, recruitment of appropriately diverse clinical trial populations through policy change and community engagement is critical to continuing to advance health equity goals.
The “Wisdom Poem” in Job 28 and its Role in Job’s Final Discourse (Job 27–31)
Authors: Frish Rachel
Published: October 2024

This article offers a fresh interpretation of Job 28 suggesting that it reflects the devout manifestation of the conventional concept of wisdom endorsed by Job’s friends. Articulated by Job, this serves as a rhetorical device in his counterargument to traditional wisdom and his challenge of God himself. The article further demonstrates that the “wisdom poem” is not an independent text but rather serves a distinct function in the rhetorical strategy of Job 27–31, which comprises Job’s final, emphatic rebuttal of his friends’ charges, framed as an oath of innocence.
Comparative analysis of intestinal flora community composition and diversity of Anas platyrhynchos and Anser fabalis in the Yellow River Delta
Authors: Liu Junpeng , Li Linqi , Shao Yan , Li Wenjuan , Li Yanzhao , Wang Hongguo , Wang Yanmei , Zhou Zhihao , Wang Jun , Shang Shuai
Published: October 2024

The Yellow River Delta wetland is a habitat for wintering waterfowl, where mallard (Anas platyrhynchos) and tundra bean goose (Anser fabalis) are commonly observed. Although the intestinal flora plays a pivotal role in maintaining host health and promoting nutrient absorption, it remains unclear whether the same overwintering habitat and challenging feeding conditions specifically affect the composition and diversity of intestinal flora in both species. Here, high-throughput sequencing was used to compare the intestinal bacterial communities of mallard and tundra bean goose from the same region. There was no significant difference in alpha diversity and beta diversity between the two species. Firmicutes and Proteobacteria were the two predominant phyla, accounting for more than 50.00% of the total. They enhanced the nutrient absorption and metabolic efficiency during overwintering. Catellicoccus was the most dominant genus in the intestinal flora of tundra bean goose, accounting for 33.91%, whereas Clostridium sensu stricto 1 was the most dominant genus in mallard, accounting for 7.34%. This difference is considered to be related to the feeding habits of these two species. No significant differences in the structure and diversity of intestinal bacterial communities were observed between mallard and tundra bean goose, and the similarity of intestinal flora between them was high. This study deepens our understanding of the intestinal flora of two coexisting species with different dietary preferences in the Yellow River Delta. It also lays the foundation for waterfowl disease prevention in this area, carrying significant scientific and practical implications for biodiversity and ecosystem conservation.
Manuscripts with the Seal of the Safavid Shrine in Ardabil at the Hekimoğlu Ali Paşa Library in Istanbul
Authors: Tanındı Zeren
Published: October 2024

Shaykh Safi al-Din Ishaq (d. 1334), who founded the Safavid (Safaviyya) Sufi order and gave his name to the Safavid dynasty, lived in Ardabil in northwestern Iran. Shah Ismaʿil (d. 1524), founder of the Safavid state, was buried in a tomb adjoining that of Shaykh Safi. Over time, a complex of buildings grew up around these two tombs and diverse objects were endowed to what became the Shakh Safi al-Din Shrine. Today, the holdings of some libraries and museums in Istanbul include manuscripts containing endowment annotations and the endowment seal of the shrine, most of which also contain the endowment seal of Hekimoğlu Ali Paşa (d. 1758), an Ottoman statesman, as well as a calligrapher, man of letters, and patron of poets. Ali Paşa served for five years in Tabriz, where he established a waqf, as well as in Ardabil and the surrounding region, before being appointed grand vizier (g.v. 1732–35, 1742–43). Shortly after he returned to the capital, he founded a complex there with a library on the grounds, to which he endowed his books, including a large number of works by poets who wrote in Persian. I argue that it must have been Ali Paşa who brought to Istanbul the manuscripts containing the endowment seal and endowment annotations of the Shaykh Safi al-Din Shrine in Ardabil.
The Mevlevīḫāne of Salonica
Authors: Tanman M. Baha
Published: October 2024

Although there is quite a rich bibliography on the history of the Mevlevīḫāne of Salonica, which holds a prominent place among the Mevlevi lodges in Ottoman Europe, the visual sources that could illuminate its architectural features were limited until today to some exterior photographs from the early twentieth century. The building itself no longer exists, save for a few scant traces. I decided to write this article when, at an auction in 2019, I came across some personal items and official documents belonging to Salahaddin Efendi, the last postnişīn (sheikh of a dervish lodge) of this mevlevihane, as well as photographs of its courtyard, kitchen, türbe (mausoleum) and cemetery, and, most importantly, the plan of the main building, which houses the semāʿḫāne (hall in which the semāʿ [the Mevlevi ceremony of prayer, song, and dance] is performed) and the türbe. I hope this essay will be of interest to those who work on Ottoman Sufi architecture and the history of the Mevlevi order in Rumelia.
Mavīzāb and Fuqqāʿ: An Ilkhanid-Period Dispute as Evidence in the Sphero-Conical Vessels Debate
Authors: Rugiadi Martina , Ghouchani † Abdullah , Keyghobadi Roshanak , Allegranzi Viola
Published: October 2024

The monolithic designation of “sphero-conical vessels,” chosen to circumvent the long-standing modern debate around the function of these objects, does not satisfy the multiplicity of terms and uses that they had in the past. A munāẓara (disputation) by Zangi al-Bukhari titled “Dispute between the mavīzāb and the fuqqāʿ of the Iranians” (presented here in full translation) provides new insight into one such use, while also expanding our understanding of everyday life in late thirteenth–early fourteenth-century Baghdad.

Drawing from this Persian work and from Arabic medieval cookery books, this essay connects the physical qualities of drinks and associated etiquettes of consumption to the materiality of surviving objects. Still raisin drinks were ladled from large metal bowls into smaller ones. Earthenware sphero-conical vessels, perhaps a group among those resembling pinecones, were used individually, to gulp down the foam of effervescent drinks.
Selected Phenomena from the Arabic Dialect of the Jews of Damascus
Authors: Matsa Shay
Published: October 2024

This article presents, for the first time, a range of features in Judeo-Damascene (JD), the spoken dialect of the Jews of Damascus, that distinguish it from the common Damascene (CD) dialect of the non-Jewish communities. The article is based on recorded interviews with Damascene Jews. This Jewish dialect is distinct from the Arabic dialect spoken by the Muslim and Christian populations of Damascus not only lexically—in the use of vocabulary from Hebrew and Romance sources—but also in some features of its phonology and morphology. Distinctive forms appear in verbal inflections, pronouns, prepositions, and other morphological categories. The article also compares JD with other Jewish dialects and vernaculars in the Levant and shows some interesting links between JD and Christian Damascene.
The Geographical and Social Stratification of Judeo-Georgian
Authors: Lomtadze Tamari , Guledani Lali
Published: October 2024

This article focuses on the variation found within Judeo-Georgian as it correlates with predetermined geographical and social categories and explores the changes it underwent as spoken by the small Jewish community remaining in Georgia and, later, as a consequence of contacts with other languages, in a new linguistic environment in Israel. The research is based on the theories and methods of variationist sociolinguistics and linguistic anthropology. Social and geographical factors were instrumental in shaping linguistic variation in Judeo-Georgian as one of the key identity markers of Georgian Jews. Geographical, social, and religious dimensions of Judeo-Georgian are discussed in relation to linguistic variables. The research builds on Sarah Bunin Benor’s (2008) distinctive linguistic repertoire approach to Jewish languages. The varieties of Judeo-Georgian spoken in Georgia were based on local/regional dialects but differed from them through the use of Hebraisms/Aramaisms, displaced dialectisms, and archaisms. Upper-class Jews largely avoided using Judeo-Georgian, middle-class Jews used it in certain speech situations, and for lower-class Jews, it was the only means of communication. Regional and social peculiarities of Judeo-Georgian, as spoken in different parts of Georgia, as well as the changes caused by immigration, are manifest in the speech varieties spoken by Georgian Jewry in Israel.
Effects of insect meals on fish digestibility, blood parameters, and economic performance: a meta-analysis
Authors: Aaqillah-Amr M.A. , Hidir A. , Ikhwanuddin M. , Fatan N.A. , Muhammad-Rahimi R. , Ning-Shahira S. , Siankhe R.G.N. , Vandenberg G.W. , Tanga C.M. , Yossa R.
Published: October 2024

This review examines the use of insect meal (IM) as a substitute for fishmeal (FM) in fish feeds within the past decade. While global interest in this alternative is growing, research on its effects on fish digestibility, blood parameters, and economic performance has been limited. Meta-analysis on the apparent digestibility coefficient revealed a negative effect summary on dry matter (−0.92) and crude lipid (−0.51), although the difference between the two groups was relatively minor. However, a positive effect summary was reported in the apparent digestibility of crude protein (0.12), suggesting a potential advantage in the utilization of protein by fish fed with IM-containing diets. Whereas meta-analysis on fish blood parameters demonstrates varying effects summary, necessitating further research. Analysis of economic performance revealed an overall better economic performance in the IM diet with an effect summary of −0.08 for feed cost and 0.00 for the economic profit index. Overall use of IM in aquafeed shows promise in improving feed quality and fish performance, potentially becoming a sustainable alternative to traditional FM. Recommendations include exploring IM’s impact on fish blood parameters through more investigations. Shifting focus from traditional measures to markers directly linked with fish health and immune response can provide more precise insights. Moreover, exploring various components of IM, such as lipids and functional elements like chitin, through simplified breakdown methods, can significantly enhance our comprehension of their nutritional value. Analyzing how each part influences fish health could pave the way for a sustainable and efficient alternative to FM in aquaculture.
The International Court of Justice Advisory Opinion on Climate Change and Future Generations
Authors: Lawrence Peter
Published: October 2024

The mandate of the ICJ advisory opinion on climate change makes reference to states’ obligations in relation to both current and future generations. This note discusses options in terms of how the Court might interpret the concept of future generations, including its definition and the possibility of extending the principle of harm prevention to include harm to future generations. This is discussed in conjunction with the principle of intergenerational equity (an integral component of sustainable development), which the Court could interpret in a manner which gives it more substance. In approaching these issues, the Court will need to be impartial in terms of the interests of developed and developing countries.