bluuebunny/crossref_metadata_2025 huggingface dataset:
A survey on random fractional differential equations involving the generalized Caputo fractional-order derivative
Authors: Ho Vu , Nguyen Dinh Phu , Ngo Hoa
Published: May 2022

The main content of this paper is focusing on introducing a general form
of random fractional differential equations (RFDEs) with the concept of
a Caputo-type fractional derivative with respect to another function.
The problem proposed here allows us to interpolate various types of
RFDEs. By applying the fixed point theorem, the results of the existence
and uniqueness of a solution of RFDE are presented. Furthermore, we also
propose a new technique called the Hybrid Laplace-like transform method
(HLTM) to solve the solutions of RFDEs in the nonlinear form. To
visualize the theoretical results, some examples and numerical
simulations are provided.
Quantum Approximated Graph Cutting: A Rapid Replacement for T-REMD?
Authors: Sandeep Samarth , Aramyan Sona , Poghosyan Armen , Gupta Vaibhav
Published: May 2022

Determining an optimal protein configuration for the employment of
protein binding analysis as completed by Temperature based Replica
Exchange Molecular Dynamics (T-REMD) is an important process in the
accurate depiction of a protein’s behavior in different solvent
environments, especially when determining a protein’s top binding sites
for use in protein-ligand and protein-protein docking studies. However,
the completion of this analysis, which pushes out top binding sites
through configurational changes, is an polynomial-state computational
problem that can take multiple hours to compute, even on the fastest
supercomputers. In this study, we aim to determine if graph cutting
provide approximated solutions the MaxCut problem can be used as a
method to provide similar results to T-REMD in the determination of top
binding sites of Surfactant Protein A (SP-A) for binding analysis.
Additionally, we utilize a quantum-hybrid algorithm within Iff
Technology’s Polar+ package using an actual quantum processor unit
(QPU), an implementation of Polar+ using an emulated QPU, or Quantum
Abstract Machine (QAM), on a large scale classical computing device, and
an implementation of a classical MaxCut algorithm on a supercomputer in
order to determine the types of advantages that can be gained through
using a quantum computing device for this problem, or even using quantum
algorithms on a classical device. This study found that Polar+ provides
a dramatic speedup over a classical implementation of a MaxCut
approximation algorithm or the use of GROMACS T-REMD, and produces
viable results, in both its QPU and QAM implementations. However, the
lack of direct configurational changes carried out onto the structure of
SP-A after the use of graph cutting methods produces different final
binding results than those produced by GROMACS T-REMD. Thus, further
work needs to be completed into translating quantum-based probabilities
into configurational changes based on a variety of noise conditions to
better determine the accuracy advantage that quantum algorithms and
quantum devices can provide in the near future.
CNN Learning Based Approach for Cardiac Arrhythmia and Congestive Heart Failure Detection
Authors: Khaleghi Esfandiar , Duran Olga , Zweiri Yahya , Augousti Andy
Published: May 2022

An electrocardiogram (ECG) pattern classification method has been
proposed to distinguish heart conditions such as arrhythmia (ARR) and
congestive heart failure (CHF) from normal sinus rhythms (NSR) using
deep convolutional neural networks (CNNs) by converting the ECG signals
into RGB images. The results demonstrate an increase in diagnostic
accuracy from 90.63% to 94.12% using a pretrained CNN model by
utilising additional data from the second lead of the ECG.
The impact on complication rates of delayed routine pessary reviews during the covid-19 pandemic: a retrospective comparative cohort study.
Authors: McNeill Esther , Lucocq James , Brown Kirsty , Kay Vanessa
Published: May 2022

The objective of this study was to identify if delayed routine pessary
reviews during the covid-19 pandemic (as per the guidance from Royal
College of Obstetrics and Gynaecology and British Society of
Urogynaecology) led to an increase in complication rates. A
retrospective comparative cohort study was conducted in NHS Tayside,
Scotland involving 300 patients (150 pre-pandemic and 150 during the
covid-19 pandemic). Their notes were reviewed to identify age, care
provider, pessary type, length of pessary usage, review date, timeframe
from previous review, bleeding/infection/ulceration, removal issues,
pessary replacement and outcome. Exclusion criteria was applied:
Patients with no pessary insitu at review, reviews at 8 months
(pre-pandemic) and reviews at
Syringaresinol attenuates kidney injury by inhibition of pyroptosis via activating the Nrf2 antioxidant pathway in diabetic nephropathy
Authors: Li Guangru , Liu Chang , Yang Lei , Feng Lifeng , Zhang Shengzheng , An Jiale , Cheng Tianwei , Li Jing , Gao Yang , Pan Zhongjie , Xu Yang , Liu Jie , Wang Yachen , Yan Jie , Cui Jianlin , Qi Zhi , Yang Liang
Published: May 2022

Background and Purpose: Diabetic nephropathy (DN) is one of the most
serious microvascular complications of diabetes that has limited
treatment options. NLRP3-initiated pyroptosis is tightly implicated in
DN progression. Mitochondrial ROS (mtROS) are a critical trigger of
NLRP3 activation. Syringaresinol, a natural plant-derived polyphenolic
compound, possesses strong antioxidant properties. However, whether
syringaresinol provides renoprotection in DN remains unclear.
Experimental Approach: The renoprotection effects of syringaresinol were
investigated in streptozotocin-induced wild-type and Nrf2-KO mice. The
underlying mechanism of syringaresinol on DN was assessed in diabetic
renal tissues and high glucose-stimulated primary renal tubular
epithelial cells as well as glomerular mesangial cells HBZY-1. Key
Results: Syringaresinol treatment ameliorated renal structural and
functional changes in streptozotocin-induced diabetic mice, including
renal hypertrophy, fibrosis, mesangial expansion, glomerular basement
membrane thickening, podocyte foot process effacement and albuminuria.
Mechanistically, syringaresinol prevented the NLRP3/Caspase-1/GSDMD
pyroptosis pathway and promoted Nrf2 expression and nuclear transfer in
both diabetic renal tissues and high glucose-stimulated primary renal
tubular epithelial cells as well as HBZY-1 cells. After that, the
nuclear-transferred Nrf2 upregulated the antioxidant genes HO-1 and
MnSOD, thereby effectively improving mitochondrial dysfunction and
decreasing excess cytosolic ROS and mtROS. Most importantly, knockout of
Nrf2 abolished the syringaresinol-mediated renoprotection and
antioxidant effects and subsequent mtROS overproduction, resulting in
the activation of NLRP3/Caspase-1/GSDMD signaling. Conclusion and
Implications: Syringaresinol attenuated diabetic renal lesions by
preventing the NLRP3/Caspase-1/GSDMD pyroptosis pathway in an
Nrf2-dependent manner. This suggests that syringaresinol may represent
promising therapeutic options for DN.
The Ethnographer’s Ethnicity
Authors: Starova Eda
Published: May 2022

Introductions to ethnographic research for university students in Macedonia are understandably starkly different from the often idealized ‘first encounters’ we read in classical anthropological texts, what Hammersley and Atkinson call “the Western ‘rite of passage’”. Students from Macedonia, during their four-year studies, conduct fieldwork in urban and rural areas of their home country, usually focusing on a different geographic region every year. Through this experience, students are introduced to a ‘foreign’ field that is often very familiar – the language is common and the general cultural context is shared. In such a fieldwork context, the question of ethnicity, as a general category of importance in the self-identification of communities and citizens of the region, as well as a category frequently present in the rhetoric of various political groups, cannot be withheld. As such, the aim of this paper is to highlight the need for including ethnicity in conversations about fieldwork in Southeastern Europe, especially in introductory courses on research methodologies. In this sense, it is not only the ethnic identity of our interlocutors that comes to interest, but that of the researcher as well, for whom it can represent either a barrier or a tool with the ability to aid the research process. The paper will examine introductory reading materials and practices in ethnography, and attempt to synthesize understandings of auto-reflexive examples of fieldwork in multi-ethnic communities or multi-ethnic ethnographic encounters by anthropologists from Macedonia to propose methods that ethnicity can be included as a significant factor and characteristic of the researcher in teaching ethnography in the Southeastern European region.
FORTALECIENDO EL APRENDIZAJE DE CONCEPTOS BÁSICOS DE LA ASTRONOMÍA EN DOCENTES EN FORMACIÓN A TRAVÉS DE UNA SECUENCIA DIDACTICA POTENCIADA POR LA OBSERVACIÓN DIURNA Y SIMULACIONES TRIDIMENSIONALES
Authors: Lugo López Nidia Danigza , Bautista López Mónica Julieth , Molina Córdoba Johan Nicolás
Published: May 2022

La enseñanza de tópicos de astronomía como: la ubicación, las estaciones y el cambio de la observación en función de la latitud del observador, a los maestros en formación es necesaria, ya que esto les ayuda a potenciar su dominio conceptual; requerido para afrontar debidamente los contextos que nutren el ejercicio docente en las aulas de clase. Por lo anterior, se diseña una secuencia didáctica denominada El Cielo y sus curiosidades: desafíos y conceptos básicos que abarca las temáticas previamente mencionadas, y se implementa con los estudiantes de la electiva de Astronomía General de la Universidad Pedagógica Nacional. La metodología empleada para estudiar el cambio conceptual es cualitativa, y recolecta información a través de cuestionarios, en este caso, con preguntas abiertas las cuales son analizadas por medio del Método De Categorías Emergentes. El avance conceptual se determinó comparando la pre y post prueba. Los resultados muestran que, si bien los profesores en formación mejoran su dominio conceptual, aún presentan dificultades al comprender el uso de los puntos cardinales como sistema de referencia y como estos afectan la observación de los astros con la latitud del observador.
A MODELAGEM ESTATÍSTICA NA ANÁLISE DE ELEMENTOS DA CULTURA CIENTÍFICA DE ESTUDANTES INGRESSANTES EM UNIVERSIDADES BRASILEIRAS: MODELOS DE MODERAÇÃO
Authors: Aleme Helga Gabriela , Bertoldo Raquel Roberta , Giordan Marcelo
Published: May 2022

As pesquisas de percepção da ciência e tecnologia (C&T) destacam o que a população conhece, entende e pratica sobre Ciência e fornecem indicadores que auxiliam na proposição e avaliação de políticas públicas em educação e C&T. Neste trabalho, desenvolvemos um estudo quantitativo com base em um modelo teórico e instrumentos previamente validados, com o objetivo de realizar uma investigação sobre a concepção de estudantes acerca de C&T. Participaram dessa pesquisa 317 estudantes ingressantes nos cursos da área de Ciências da Natureza de uma universidade pública brasileira. O tratamento estatístico das respostas se deu em duas etapas: a primeira consistiu na redução dimensional e construção de índices usando a análise de componentes principais e avaliação da consistência interna (alpha de Cronbach); na segunda, realizamos testes de dependência bivariadas e multivariadas por meio de regressão linear e correlação, além de análise de efeito de moderação. Dentre os resultados, salientamos que houve correlação positiva entre interesse e informação em C&T, dependência da autoeficácia em relação às aulas de Ciências, bem como a influência da moderadora aulas de ciência na relação entre interesse e informação em C&T. Ressaltamos a potencialidade de utilizar a modelagem estatística para estudo de outros grupos sociais a fim de construir indicadores estáveis de Percepção Pública da Ciência.
Aprender sobre síntesis de proteínas: La lógica de los estudiantes al representar modelicamente
Authors: Castronuovo Susana Beatriz , Acevedo Laura Cecilia
Published: May 2022

Presentamos reflexiones enmarcadas en una investigación que estudia la función epistémica que cumplen las representaciones no textuales para aprender contenidos específicos de Biología. En este trabajo describimos y analizamos las acciones que realizan los estudiantes ante el pedido de representar cuando se les propone concebir el vínculo entre las proteínas, sintetizadas a nivel molecular, y su funcionamiento a nivel sistémico. Se asumió un estudio cualitativo de carácter descriptivo e interpretativo, recuperando algunos lineamientos de la Ingeniería Didáctica, lo que involucra la concepción y diseño, puesta en aula y análisis de una secuencia de enseñanza. La implementación se realizó en dos cursos de entre veinte y treinta estudiantes de un Profesorado de Biología de la Provincia de Buenos Aires, Argentina. El análisis de las producciones de los alumnos nos permite sostener que existe una lógica presente en el momento de dibujar. Identificamos que los estudiantes: siguen un orden; seleccionan qué incluir y con qué tipos de marcas hacerlo; se apoyan en modelos convencionales ya conocidos; y excluyen aquellas ideas que no pueden argumentar en la oralidad. Estas dimensiones de análisis son ilustradas con representaciones prototípicas del conjunto de elaboraciones que conforman el corpus empírico de la investigación. Concluimos que tales acciones guardan relación con el conocimiento que portan del tema y con el grado de iconicidad o de abstracción que presenta el objeto representado para quien dibuja, lo que nos lleva a advertir la necesidad de seguir estudiando las relaciones entre lo conceptual y lo figurativo, interpretando que dichas vinculaciones no son biunívocas.
ABORDAGENS INTERDISCIPLINARES NA FORMAÇÃO INICIAL DE PROFESSORES DAS CIÊNCIAS DA NATUREZA E DA MATEMÁTICA: DESAFIOS ENFRENTADOS
Authors: Drehmer-Marques Keiciane Canabarro , Sauerwein Inés Prieto Schmidt
Published: May 2022

O objetivo desta pesquisa é apresentar e discutir os desafios enfrentados na implementação de práticas interdisciplinares na formação inicial dos licenciandos da área das Ciências da Natureza e da Matemática. A pesquisa é de natureza qualitativa e teve como sujeitos de pesquisa licenciandos dos cursos de Ciências Biológicas, Física, Matemática e Química, da Universidade Federal de Santa Maria (UFSM). A metodologia utilizada no Projeto Interlicenciaturas foi a Pesquisa de Design Educacional, a qual identifica problemas reais e busca solucioná-los. Os dados foram obtidos por meio de um questionário de inscrição no projeto de ensino, questionário de avaliação final, observações e anotações; as análises ocorreram por meio de estatística descritiva e da análise de conteúdo. Os resultados indicam diversos obstáculos em relação ao planejamento e à execução do projeto com perspectiva interdisciplinar. Os desafios que emergiram foram: incompatibilidade de horários para realização do projeto, captação e manutenção dos licenciandos participantes, alta variabilidade de semestres entre os graduandos, resistência em construir atividades interdisciplinares, dificuldades de relacionamentos com os colegas de grupo, falta de tempo para realizar as atividades e para reunir-se com o grupo. Foram realizadas diferentes ações, buscando superar os desafios enfrentados na implementação de práticas interdisciplinares, como reorganização dos grupos de trabalho, além de momentos de orientação e mediação com esses, também, contamos com a contribuição de professores externos como colaboradores do projeto.
DIVULGAÇÃO CIENTÍFICA ITINERANTE E OS EDITAIS DE POPULARIZAÇÃO DA CIÊNCIA: ANÁLISE DE PROJETOS SUBMETIDOS AO CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO (CNPQ) (2003-2015)
Authors: De Abreu Willian Vieira , Norberto Rocha Jessica , Massarani Luisa , Peçanha Carolina Chaves
Published: May 2022

O presente estudo, de caráter exploratório e de análise documental, visa identificar e analisar as ações de divulgação científica itinerantes financiadas pelos editais de popularização da ciência do Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), entre os anos de 2003 e 2015. A amostra total foi composta por 245 projetos aprovados em 26 editais estudados. Para análise, foram aplicados métodos mistos que exploram dados quantitativos e qualitativos. Os resultados apontam que, de forma geral, os editais obtiveram, ao longo dos anos, adesão de instituições públicas do país. Sobressaíram a diversidade de tipos de ações de divulgação científica itinerante (embora em sua maioria projetos propunham exposição móvel, seguidos de oficinas, cursos e ações de astronomia), a variada gama de temáticas e a relação estreita com o público escolar. Todos os estados brasileiros tiveram pelo menos uma proposta de itinerância aprovada sinalizando que essa política pública pode adentrar diversas regiões e potencialmente favorecer populações que não têm acesso à divulgação científica. Universidades e instituições de pesquisa públicas foram as que mais tiveram propostas aprovadas, destacando seu protagonismo na popularização da ciência no país. Finalizamos destacando a relevância do desenvolvimento de estudos como esses para compreender a complexidade e abrangência de políticas públicas voltadas para a popularização da ciência e tecnologia no país, bem como para sustentar práticas futuras.
An identity involving derangement numbers and Bell numbers
Authors: Du Zhibin , da Fonseca
Published: May 2022

The aim of this paper is to establish a new identity between derangement
numbers and Bell numbers. Two known identities can be recovered. We provide
a combinatorial interpretation for the new identity and a representation of
the derangement numbers in terms of the determinants of Hessenberg matrices.
Nanocomposites made from thermoplastic linear poly(urethane-siloxane) and organoclay: Composition impact on the properties
Authors: Pergal Marija , Ostojic Sanja , Steinhart Milos , Stefanovic Ivan , Pezo Lato , Spírková Milena
Published: May 2022

Thermoplastic poly(urethane-siloxane)/organoclay nanocomposites (TPU NCs) with different hard segment content (20?55 wt. %) were prepared by in situ polymerization in the presence of organically modified montmorillonite as a nanofiller (Cloisite 30B; 1 wt. %). Hydroxyl-terminated ethoxypropyl- poly(dimethylsiloxane) was used as soft segment, while 4,4'-methylenediphenyl diisocyanate and 1,4-butanediol were the hard segment components. The study of the influence of the hard segment content on the functional properties of TPU NCs was performed by Fourier transform infrared (FTIR) spectroscopy, X-ray diffractometry (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM), dynamic mechanical thermal analyses (DMTA), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), water contact angle and water absorption tests. The results revealed that TPU NCs with the increasing hard segment content exhibit higher values of degree of microphase separation, melting temperature of the hard segments, degree of crystallinity, storage modulus (except for TPU NC-55), but lower thermal stability and hydrophobicity. TPU NC films were hydrophobic and their free surface energy was in the range from 17.7 to 24.9 mJ m-2. This work highlights how the composition of TPU NCs would affect their functional properties and provide an additional composition intended for designing advanced TPU NC materials for special biomedical applications.
Angels and Food in “Paradise Lost”
Authors: Low Anthony
Published: May 2022

The meal in the Garden shared by Raphael, Adam, and Eve is a symbol of hospitality, of an ideal relationship between man and angel. Its abundance reveals God's goodness, while its simplicity underlines man's innocence. The fruits of the earth which compose it contrast with man's postlapsarian diet. It represents the close ties before the fall between heaven and earth, God and man. Though not “sacramental,” it is a “solemnity” that reinforces these ties. It reflects the heavenly feasts described by Raphael, symbolizing the beatific state, up to which man one day will be drawn. Because it has these meanings, Milton uses the meal with Raphael as a symbol of all that is lost when he changes his notes to “tragic.” The value of what the meal stands for is seen most clearly from the vantage point of the last books, and especially in the contrast between Raphael's visit and Michael's.
How Do Non-Professional Investors, Jurors, and AICPA Peer Reviewers Evaluate Data and Analytics-Based Substantive Auditing Procedures?
Authors: Ballou Brian , Grenier Jonathan H. , Mitchell Lettie , Ngwa Tyler , Reffett Andrew
Published: May 2022

To minimize the associated risks (e.g., litigation, regulatory scrutiny) of implementing increasingly advanced data and analytics-based substantive auditing techniques, audit firms should ensure that key audit stakeholder groups sufficiently understand such procedures and believe that they maintain or elevate audit quality. However, little is known about how various stakeholder groups view data and analytics-based substantive procedures. Ballou, Grenier, and Reffett (2021) address this question by examining how three key audit stakeholder groups (investors, jurors, and AICPA peer reviewers) view two commonly employed data and analytics-based auditing techniques (population testing and predictive modeling). Our paper summarizes Ballou et al.'s (2021) study by summarizing its research questions, experimental method, and results. We then conclude with a discussion of the study's implications for audit practice and, in particular, the steps that audit firms should take to ensure stakeholder comfort.
Demineralization Inhibition by Two Calcium-releasing Restorative Materials
Authors: Huang CT , Burgess JO , Robles A , Lawson NC
Published: May 2022

Objective

To compare the ability of two calcium-releasing restorative materials to inhibit root dentin demineralization in an artificial caries model.

Methods and Materials

Preparations were made at the cementum–enamel junction of extracted human molars (40, n=10/material) and restored with two calcium-releasing materials (Experimental composite, Pulpdent Corporation and Cention N, Ivoclar Vivadent), a resin composite (Filtek Supreme Ultra, 3M Oral Care), and a resin-modified glass ionomer (RMGI) (Fuji II LC, GC). All materials (other than the RMGI) were used with an adhesive (Scotchbond Universal Adhesive, 3M Oral Care) in the self-etch mode, which was light cured for 10 seconds. All restorative materials were light cured in 2-mm increments for 20 seconds and then finished with a polishing disc. Teeth were incubated (37°C) for 24 hours in water. An acid-resistant varnish was painted onto the teeth around the restoration, leaving a 2-mm border of uncovered tooth. A demineralization solution composed of 0.1 M lactic acid, 3 mM Ca3(PO4)2, 0.1% thymol, and NaOH (to adjust pH=4.5), and a remineralization solution composed of 1.5 mM Ca, 0.9 mM P, and 20 mM Tris(hydroxymethyl)–aminomethane (pH=7.0) were prepared. Specimens were placed in the demineralization solution for 4 hours, followed by the remineralization solution for 20 hours and cycled daily for 30 days. The specimens were embedded, sectioned into 100-μm sections, and the interface between the restorative material and root dentin was viewed with polarized light microscopy. A line was drawn parallel with the zone of demineralization for each tooth. The area of “inhibition” (defined as the area external to the line) or “wall lesion” (defined as the area internal to the line) was measured with image evaluation software. Areas of inhibition were measured as positive values, and areas of wall lesions were measured as negative areas.

Results

A one-way analysis of variance (ANOVA) found significant differences between materials for “inhibition/wall lesion” areas in root dentin (p<0.001). Tukey post hoc analysis ranked materials (μm2, mean ±SD): Fuji II LC (5412±2754) > Cention N (2768±1576) and experimental composite (1484±1585) > Filtek Supreme Ultra (−1119±1029).

Conclusion

The experimental composite and Cention N materials (used with an adhesive) showed net areas of inhibition greater than a reference resin composite, albeit at a lower level than a reference RMGI material (used with no adhesive).
Ambient carbon monoxide correlates with mortality risk of hemodialysis patients: comparing results of control
selection in the case-crossover designs
Authors: Huh Hyuk , Kim Ejin , Yoon Una Amelia , Choi Mun Jeong , Lee Hyewon , Kwon Soie , Kim Clara Tammy , Kim Dong Ki , Kim Yon Su , Lim Chun Soo , Lee Jung Pyo , Kim Ho , Kim Yong Chul
Published: May 2022

Background: Growing evidence suggests that environmental air pollution adversely affects kidney health. To date, the association between carbon monoxide (CO) and mortality in patients with end-stage renal disease (ESRD) has not been examined. Methods: Among 134,478 dialysis patients in the Korean ESRD cohort between 2001 and 2014, 8,130 deceased hemodialysis patients were enrolled, and data were analyzed using bidirectional, unidirectional, and time-stratified case-crossover design. We examined the association between short-term CO concentration and mortality in patients with ESRD. We used a two-pollutant model, adjusted for temperature as a climate factor and for nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone (O3), and particulate matter less than 10 μm in diameter as air pollution variables other than CO. Results: Characteristics of the study population included age (66.2 ± 12.1 years), sex (male, 59.1%; female, 40.9%), and comorbidities (diabetes, 55.6%; hypertension, 14.4%). Concentration of CO was significantly associated with all-cause mortality in the three case-crossover designs using the two-pollutant model adjusted for SO2. Patients with diabetes or age older than 75 years had a higher risk of mortality than patients without diabetes or those younger than 75 years. Conclusion: Findings presented here suggest that higher CO concentration is correlated with increased all-cause mortality in hemodialysis patients, especially in older high-risk patients.
Recent advances in electron microscopy for the diagnosis and research of glomerular diseases
Authors: Honda Kazuho , Takaki Takashi , Kang Dedong
Published: May 2022

Recent technical advances in the detection of backscattered electrons during scanning electron microscopy (SEM) have improved resolution and have provided several new technologies for research and clinical practice in kidney disease. The advances include three-dimensional (3D) electron microscopy (3D-EM), correlative light and electron microscopy (CLEM), low-vacuum SEM (LVSEM), and scanning transmission electron microscopy (STEM). 3D-EM analysis used to be laborious, but recently three different technologies, serial block-face SEM, focused ion beam SEM, and array tomography, have made 3D-EM easier by automating sectioning and the subsequent image acquisition in an SEM. CLEM is a method to correlate light microscopic images, especially immunofluorescent and electron microscopy images, providing detailed ultrastructure of the area of interest where the immunofluorescent marker is located. LVSEM enables the use of SEM on materials with poor electron conductivity. For example, LVSEM makes it possible for high resolution, 3D observation of paraffin sections. Finally, STEM is a method to observe ultrathin sections with improved resolution by using the focused electron beam scanning used in SEM and not the broad electron beam used in transmission electron microscopy. These technical advances in electron microscopy are promising to provide plenty of novel insights for understanding the pathogenesis and diagnosis of various glomerular diseases.
Albuminuria, estimated glomerular filtration rate, and traditional predictors for composite cardiovascular and
kidney outcome: a population-based cohort study in Korea
Authors: Jung Hae Hyuk
Published: May 2022

Background: Certain pharmacotherapies have shown to be effective for both cardiac and kidney outcomes. Although risk prediction is important in treatment decision-making, few studies have evaluated prediction models for composite cardiovascular and kidney outcomes. Methods: This study included 2,195,341 Korean adults from a nationwide cohort for chronic kidney disease and a representative sample of the general population, with a 9-year follow-up. This study evaluated prediction models for a composite of major cardiovascular events or kidney disease progression that included albuminuria and estimated glomerular filtration rate (eGFR) and/or traditional cardiovascular disease predictors. Results: The addition of albuminuria and eGFR to a model for the composite outcome that included age, sex, and traditional predictors increased a C statistic by 0.0459, while the addition of traditional predictors to age, sex, albuminuria, and eGFR increased a C statistic by 0.0157. When age and sex-adjusted incidence rates were calculated across the combined Pooled-Cohort-Equations (PCEs) and Kidney Disease: Improving Global Outcomes (KDIGO) risk categories in diabetic or hypertensive participants, the incidence of ≥10 per 1,000 person-years was observed among all categories with high or very high KDIGO risk and among categories with moderate (or low) KDIGO risk and a PCEs 10-year risk of ≥10% (or ≥20%), accounting for 36% of diabetic and 18% of hypertensive populations. Conclusion: This study strongly supports the utility of the KDIGO risk matrix combined with a conventional cardiovascular risk score for the prediction of composite cardiovascular and kidney outcome and provides epidemiologic data relevant to the development of efficient treatment strategies.
Colonial Roots of Environmental Degradation of the Elgeyo Escarpment and the Search for Livelihoods
Authors: KIPKOSGEI EVELYN , Tarus Dr.Isaac
Published: May 2022

The Keiyo who inhabits and occupy the southern part of the Elgeyo escarpment are the subject of this study. Before the 1970s, the escarpment was carpeted with lush, semi-tropical vegetation. But due to factors associated with human activities, a large part of the mountainous slopes has been destroyed together with its ecosystems. It is a study in historical context that traces the demographic profile of the Keiyo and the economic challenges that they have faced in search of livelihoods. The study is about understanding the relationship between history, environmental degradation and peasant livelihoods. The theoretical starting point is provided by Kirk’s environmental perception mode and studies on human behavioural characteristics. The Keiyo are culpable of reckless destruction of their ecosystem with devastating consequences of death, deluge and destruction. Landslides that have become a common occurrence began from the 1980s. This has been blamed on wanton tree cutting for charcoal and the use of fire to clear land for the cultivation of maize.
Public Relations Strategy of Hotel Budget in Surabaya in Building Brand Loyalty
Authors: Purnama Hayuning
Published: May 2022

Purpose: This study aims to determine the efforts made by budget hotel public relations in competing in the hotel industry. The number of budget hotels is increasing.

Result:  Based on the research results, it can be concluded that: most of the public relations strategies in creating brand loyalty for budget hotels in Surabaya have been carried out by internal parties properly but have not been optimal because budget hotels in Surabaya still lack in conducting reviews related to facilities outside the room, for example, ballrooms, or parking lots, meeting places, and others that support multi-functional activities;

Originality: The process of public relations activities in creating brand loyalty for budget hotels in Surabaya is still focused on room facilities and the services offered, while the budget is not explained in detail. As such, it confuses prospective hotel service users. Budget hotel users in Surabaya are included in the satisfied buyer level, indicating that the budget hotel brands have been well recognized by the customers, although the results are quite satisfying but have not met the expectations of the hotels' public relations in Surabaya.

Implication: Thus, it is still necessary to develop a public relations strategy to move customers to the committed buyer level, in which customers are loyal and will always return to stay at the hotels offered on the Traveloka website.

 

Keywords: communications strategy, increase, budget hotel
COVID-19 Pandemic and Violence Against Children
Authors: Tristanto Aris
Published: May 2022

During the COVID-19 pandemic , it was known that number violence to child in Indonesia more increase . Study this is study References with objective for study reason happening violence against children During the COVID-19 pandemic and effort in prevention . F actor common causes of hard cake  on children during the COVID-19 pandemic is a problem economy as a result of activity restrictions during pandemic, the relationship between children and parents who are not balanced , and low parental knowledge related with parenting patterns. Impact period short of perceived violence children is to affect the child 's physical , while the impact long-term related to the psyche of the victim. In overcoming _ The problem of violence against children during the COVID-19 pandemic must be carried out in a social environment with various preventive measures. On In this research , the author suggests there needs to be awareness, that acts of violence against children are extraordinary crimes that can interfere with the growth and development of children.
Para la construcción del diálogo intercultural con mirada de género en bioética. Aportes desde la Ética Social Latinoamericana
Authors: Arpini Adriana María
Published: May 2022

Aportamos a la compleja y problemática relación entre interculturalidad, género y bioética desde la perspectiva de la Ética Social Latinoamericana. Repasamos en primer lugar momentos de la constitución y desarrollo de la Ética Social Latinoamericana e identificamos categorías que abren posibilidades de articularse con la crítica de la filosofía intercultural y las epistemologías feministas decoloniales. Consideramos también las críticas a la noción de reconocimiento desde planteos de la filosofía intercultural latinoamericana y avanzamos hacia los planteos de la diversidad de género y las críticas de los feminismos latinoamericanos, para incorporar otras voces en la argumentación bioeticista, que hablan de cuidado, solidaridad, (co)responsabilidad, compromiso.
Aportes para pensar la interculturalidad en el campo de estudio de la salud del migrante. El caso de mujeres migrantas andinas en Argentina
Authors: Baeza Brígida , Aizenberg Lila
Published: May 2022

Nos interesa compartir una serie de aportes vinculados al campo de la salud intercultural en relación a los grupos migrantes limítrofes en Argentina. Recuperamos parte de la discusión en torno a las categorías de interculturalidad, pluralismo médico, itinerarios terapéuticos entre otros conceptos junto al de interseccionalidad y memoria para aportar a la discusión sobre interculturalidad y salud migratoria. Buscamos poner en cuestión estas categorías a la luz de la salud de las mujeres migrantas andinas en Argentina, área de estudio desde donde hace algunos años venimos reflexionando dentro del campo de la salud, la interculturalidad y el género.
Justicia, salud y las políticas de la diferencia. Reflexiones a partir de las demandas de los movimientos sociales de Argentina
Authors: Kaufman Jessica Marcela
Published: May 2022

La justicia sanitaria ha sido entendida, tradicionalmente, apenas como la aplicación del modelo distributivo de la justicia social al campo de la salud. El objetivo del presente artículo consiste en analizar, a partir del enfoque de Iris Young sobre las “políticas de la diferencia”, otras nociones de justicia sanitaria, contenidas en las demandas de diferentes movimientos sociales de Argentina. En función del análisis mencionado, ha sido posible identificar cuatro nociones que, si bien presuponen aspectos vinculados con la distribución de recursos, están, sin embargo, lejos de reducirse al modelo distributivo de la justicia.
Main Title: Quanton Based Model of Field Interactions,
Authors: Kassem Ayman
Published: May 2022

The search for a unification of the physical phenomena was the preoccupation of many physicists for long time. Starting from the seventeenth century with the unification of celestial mechanics and gravitation, then the unification of the electromagnetism in the nineteenth century. The early twentieth century brought about the unification of space and time and the unification of energy and mass while the advent of gauge theory enabled the unification of the weak interaction with the electromagnetism in the middle of the twentieth century. More recent theories are proposed as the answer to the unification question in physics include quantum gravity which unifies quantum mechanics and gravitation, and string theory. Unification effort should not only address the known fundamental forces but the space fabric interactions which till now remain unknown but their manifestations are described as the dark energy and dark matter. Here the concept of interacting space and time fields which constitute space time is discussed using classic method which has a certain advantage of bringing the physical meaning into visualization.
Efeitos jurídicos do registro socioafetivo decorrente da multiparentalidade
Authors: Novack Luane Tais , Trevisani Anieli Schiessl
Published: May 2022

Sabe-se que as decisões judiciais envolvendo pedidos de registro civil para registro da multiparantalidade são avaliadas com base no princípio da afetividade, que compõe o alicerce do direito das famílias, pois possui o condão de contrabalançar as relações socioafetivas em situações de origem patrimonial ou biológica. Diante disso, o presente trabalho tem como objetivo geral demonstrar a possibilidade do registro da dupla filiação levando em consideração o princípio do afeto, provocando uma reflexão acerca da evolução legislativa da afetividade, da filiação no contexto da nova família, além de esclarecer a questão parental e reafirmar o fundamento jurídico de que as emoções prevalecem nas questões biológicas. O estudo possui como base uma pesquisa bibliográfica e documental, de caráter dedutivo, pois está fundamentada em artigos, jurisprudências, doutrinas e leis que subsidiaram a discussão do tema proposto, tendo sido evidenciado a relevância da afetividade no registro da dupla paternidade e, ou, maternidade. Pode-se concluir que a multiparentalidade é um tema relevante no âmbito do Direito de Família Contemporâneo, consolidando a afetividade como verdadeiro princípio do sistema jurídico nacional, com consequências jurídicas efetivas no âmbito familiar, mormente aos direitos de educação, alimentos, sucessão, entre outros.
Medicina um ator privilegiado?
Authors: Alcantara Sarah Bernadete de Carvalho
Published: May 2022

Pensar sobre a ciência médica em um universo de implicações humanas, sociais e politicas sob o olhar filosófico, implica em perceber as relações de poder. Ao encontrá-las, encontra-se, também filósofos como Deleuze e Foucault, que de forma tão aberrante, revelaram a realidade da doença, e nela toda a engrenagem de um mundo que se apoderou da vida. Biopoder e biopotência, duas forças expressas na máquina abstrata, fruto da leitura de Deleuze sobre o diagrama de forças de Foucault. Aspectos atuais são abordados  quanto à medicina, e todos confluem para o mesmo ponto: as infinitas possibilidades de invenção frente a uma concepção de potência do corpo, quando este é entendido, além do seu limite espacial, em seu contexto das relações, em uma biopolitica que não suporta mais ser calada.
Palavras-Chave: Saúde. Filosofia. Medicina.
Dispositivo ontológico
Authors: Nunes Marcus Vinicius de Souza
Published: May 2022

A noção de técnica desempenha um importante papel na filosofia de Martin Heidegger. Já em Ser e Tempo, sob a categoria da instrumentalidade, a técnica aparece como uma espécie de destino do ser. Este artigo apresenta uma leitura de A questão da técnica do filósofo alemão na perspectiva da arqueologia da ontologia de Giorgio Agamben. A pesquisa mostrará que reconhecer a noção de Ge-Stell heideggeriana como integrante do campo semântico do dispositivo de Agamben indica a possibilidade de localizar a história também teológica de desenvolvimento da técnica. Além disso, será possível evidenciar que o conceito de Heidegger não dá conta de um anterior desenvolvimento da noção de instrumentalidade que já aparece na obra de Tomás de Aquino e que se tornará importante para Agamben entender a técnica como a operação do corpo vivo pelos dispositivos de subjetivação.
Palavras-chave: Ontologia. Ge-Stell. Metafísica. Tecnologia. Instrumentalidade.
EUGENIA PACHAKUMACHIANA (MYRTACEAE), A NEW SPECIES FROM THE WESTERN GHATS, INDIA
Authors: Murugan C. , Arumugam S.
Published: May 2022

Eugenia pachakumachiana Arum. & Murugan, a species from Megamalai Wildlife Sanctuary, southern Western Ghats of Tamil Nadu, India, and new to science is described and illustrated. The species is compared with its closely allied species Eugenia rottleriana Wight & Arn. and incorporated into a key of Indian Eugenia species.
Ethik der Existenz - Das Neue Denken bei Rosenzweig, Heidegger, Lévinas und Nancy
Authors: Möbuß Susanne
Published: May 2022

Wie kann eine Theorie der Ethik beschaffen sein, wenn sie aus dem gedanklichen Repertoire der Existenzphilosophie entworfen wird? Sie bedarf vor allem einer speziellen Sprachfindung, die einen Diskurs mit zeitgenössischen Ethik-Konzeptionen im ersten Moment zu erschweren scheint. Susanne Möbuß zeigt auf, dass dieses nicht zwangsläufig gilt, wenn der strukturelle Rahmen, in dem die Ethik der Existenz sich artikulieren kann, in die Untersuchung einbezogen wird. Hier kommt das Konzept des Neuen Denkens zum Tragen, das 1925 von Franz Rosenzweig vorgestellt wurde. Zum ersten Mal ist es möglich, die Bedeutung des Rosenzweig’schen Denkens für die Entwicklung von Existenzphilosophie und Dekonstruktion darzustellen.
Coming Home to Family: The Role of Friendship in Karen McBride’s Crow Winter
Authors: Tsai Ruei-Shin
Published: May 2022

My presentation examines the complicated but healing journey between Hazel and Nanabush, the Anishinaabe transformer and trickster figure, in Karen McBride’s Crow Winter. After the loss of her father, Hazel returns to her roots at the Spirit Bear Point First Nation reserve to reconnect with her culture. While she tries to process her grief, she accidentally stumbles upon the Western doorway, which marks the beginning of an unexpected alliance with Nanabush. The two characters go through trials and tribulations, exploring the necessity of conflicts and the importance of reciprocity as they share their vulnerabilities. By having one another to rely on in times of need, Hazel and Nanabush learn to navigate their place and sense of belonging between two worlds.
BRUXISMO INFANTIL: FATORES ETIOLOGICOS, CONSEQUENCIAS E TRATAMENTO
Authors: De Melo Bortoleto Bruna , Hyppolito Elias Leticia , Maria Tognetti Valdinéia
Published: May 2022

O bruxismo é um hábito parafuncional definido pelo ato de ranger e apertar os dentes de forma voluntária e/ou involuntaria, ocorre tanto de dia como à noite durante o sono, podendo acarretar danos ao sistema estomatognático. Muito recorrente na odontologia pode ocorrer já nos primeiros anos de vida de um paciente. As causas etiológicas são variadas e por isso é difícil se fazer um diagnóstico preciso, entre elas pode se citar fatores locais, sistêmicos, hereditários, psicossociais e comportamentais. Como não existe uma única etiologia para o bruxismo, as formas de tratamento são diferentes e individualizadas para cada paciente. O diagnóstico em crianças precisar ser realizado precocemente, a fim de prevenir danos e assim proporcionar o bem estar geral do paciente. Essa breve revisão de literatura tem por objetivo explorar as etiologias, o tratamento do bruxismo infantil, além das consequências que este hábito traz para o dia dos pacientes.
CANCER GASTRICO CORRELACIONADO AO H. PYLORI
Authors: Germana da Silva Larissa , Manoel Della Coletta Amanda
Published: May 2022

O câncer é a segunda maior causa de morte no mundo e, entre seus muitos tipos, está o câncer gástrico, que, segundo o Instituto Nacional de Câncer (INCA), é a terceira maior neoplasia a acometer o sexo masculino e a quinta nas mulheres no Brasil. Estudos apontam uma importante relação entre o câncer gástrico e a bactéria Helicobacter pylori (H. pylori), sendo que 50% da população mundial tem infecção pela mesma, mas nem todos desenvolvem o câncer. O objetivo deste artigo é abordar a correlação entre o câncer gástrico e a infecção por H. pylori, além de disseminar conhecimento sobre o assunto, oportuno à saúde pública que merece mais atenção. A epidemiologia da infecção por H. pylori é pouco retratada, logo sua analogia como principal fator causal do câncer gástrico é obscura à população, entretanto, é importante ressaltar que a prevenção existe e, caso o câncer seja descoberto precocemente, há cura. Foi realizada, no período entre 2000 e 2021, uma pesquisa bibliográfica das bases de dados eletrônicas Scielo, Google acadêmico, INCA, periódicos Capes, LILACS, Associação Brasileira de Câncer Gástrico, através dos descritores: “H. pylori”, “câncer gástrico”, “H. pylori e câncer gástrico”, “correlação entre câncer gástrico e H. pylori. Destaca-se assim uma importante relação entre ambos acerca da doença. É possível concluir que o câncer gástrico associado à infecção pelo H. pylori pode se apresentar como uma patologia silenciosa, portanto, a prevenção e identificação precoce podem contribuir para o tratamento, uma vez que diagnosticado a tempo, há tratamento ativo e condizente.
Journalology – academic publishing process
Authors:   Institute of Information Technology, Azerbaijan National Academy of Sciences, Asgarov Firudin
Published: May 2022

In the paper, we provide information about journalology - as the science of publication, and its history. We give brief information on metascience, open science, scientometrics and bibliometrics related to journalism. Journalology includes identifying predatory journals and publishers, choosing the right journal for publication, and generally producing qualitative articles. The establishment of Journalology Center in every higher education and research institute has been suggested to inoculate this knowledge in students and young researchers. The center also includes rules for publishing qualitative journals. This creates opportunities for journals to be indexed in international academic databases.
Análisis de la frontera entre Colombia y Panamá como pivote hacia Centro América: frontera confiable
Authors: Ramírez Villegas Oscar Mario
Published: May 2022

El análisis de la frontera terrestre y marítima entre Colombia y Panamá permite formular una estrategia que admita fortalecer el trabajo bilateral en materia de seguridad y desarrollo, con el fin de proyectar la zona de frontera como un pivote de Colombia hacia Centroamérica. Desde la experiencia del Centro de Estudios Estratégicos sobre Seguridad y Defensa Nacionales de la Escuela Superior de Guerra, se presenta la posibilidad de evaluar las amenazas trasnacionales, en especial para la frontera colombiana. Por ello, la idea es brindar una visión geopolítica, geoestratégica y geoeconómica hacia el Darién, que pueda abarcar los intereses nacionales, las amenazas y las oportunidades, teniendo en cuenta las relaciones dentro del sistema internacional de ambos Estados (política exterior, influencia de los países en potencia, resistencia al desarrollo fronterizo, cooperación conjunta, representaciones adecuadas), las estrategias en desarrollo (militar y diplomática), la seguridad, la defensa y la inteligencia estratégica, a fin de comprender el contexto desde un marco teórico y conceptual, y de ofrecer una propuesta de estrategia diferente o que supere la actual.