bluuebunny/crossref_metadata_2025 huggingface dataset:
La globalisation du genre
Authors: Lacombe Delphine
Published: November 2022

En prenant pour fil conducteur la problématisation publique des violences envers les femmes au Nicaragua, le texte met au jour les modes d’interconnexion des effets de politisation globaux et localisés ayant trait aux rapports sociaux de sexe. Il analyse en particulier le rôle catalyseur de la rhétorique des droits humains aux échelles nationales puis internationales pour penser conjointement l’égalité, la liberté de disposer de soi articulée au droit de disposer librement de son groupe revendicatif, et la mise au ban des violences. Il montre combien la diffusion accélérée, à l’échelle internationale, du langage de l’inclusion des droits des femmes dans les droits humains, est captée au Nicaragua à partir d’une dynamique similaire déjà en cours durant la révolution sandiniste, portée par l’émergence d’un féminisme de la deuxième vague. Il explique dans un second temps comment les mobilisations de registres scientifiques internationaux ont conforté la juridisation des violences intrafamiliales en 1996, annonçant l’installation pérenne de ce thème d’action publique dans la société nicaraguayenne.
La globalisation du genre
Authors: Freedman Jane
Published: November 2022

Des discours et des politiques visant les violences basées sur le genre et en particulier les violences sexuelles ont été mobilisés par de multiples acteurs pour mettre en place des programmes de prévention et de soutien aux victimes en République démocratique du Congo (RDC). Sur la base de savoirs produits dans la sphère internationale, des moyens financiers et techniques importants sont dispensés mais les programmes ignorent parfois les réalités des positions sociales, économiques et politiques des femmes congolaises et peuvent avoir des impacts négatifs sur leurs vies. Des définitions limitées des violences sexuelles et basées sur le genre ont ainsi mené à l’échec de plusieurs interventions internationales entraînant la dégradation des conditions de vie dans le pays. Les énormes flux de fonds internationaux ont créé un « marché » pour les programmes et les projets, mais rien n’est cependant fait pour trouver des solutions à long terme en agissant sur les causes profondes des problèmes : inégalités économiques, lois et coutumes discriminatoires, exclusion des femmes du pouvoir politique. La concentration des interventions internationales sur une forme particulière de violence – le viol pendant les conflits et par les groupes armés – peut être comprise comme une forme de biopolitique de développement, dans laquelle les interventions onusiennes et des ONG ciblent « les femmes comme corps » soumis aux violences.
Des morts sous-estimés ? La reconnaissance des victimes civiles de la première guerre mondiale sur les monuments aux morts du Nord
Authors: Diest Philippe
Published: November 2022

Comme les autres départements français, le Nord a payé un lourd tribut humain durant la première guerre mondiale. De nombreux monuments aux morts furent élevés en hommage aux militaires disparus mais certains de ces édifices entretiennent la mémoire des victimes civiles. Cette originalité des régions envahies, dont le Nord constitue un excellent exemple, interroge les décisions politiques, les représentations sociales et culturelles de l’époque et la fabrique d’une hiérarchie entre les morts de la Grande Guerre.
Quand le déni des droits s’appuie sur l’ignorance du droit
Authors: Lucas Barbara , Delessert Yves , Sgier Léa , Meigniez Maëlle
Published: November 2022

Cette contribution traite de l’accès aux droits politiques dans le contexte des établissements médico-sociaux (EMS) pour personnes âgées en Suisse romande. Sur la base d’une enquête approfondie au sein de ces établissements, nous montrons comment le milieu institutionnel lui-même peut faire obstacle au vote des résidents, plus que le vieillissement en tant que tel ou les dynamiques de désengagement social qui l’accompagnent souvent. Notre analyse s’appuie sur le courant issu de l’analyse de la street level bureaucracy , qui montre l’importance, pour l’effectivité du droit, des marges discrétionnaires que les agents de terrain mobilisent. Elle s’inspire aussi des Legal Consciousness Studies , qui cherchent à saisir le rapport que les citoyens ordinaires entretiennent avec le droit. Notre enquête montre que les directions d’établissement et leurs personnels sont en position d’interpréter un cadre légal à la fois strict et complexe en matière de droit de vote. Elle identifie les pratiques qui restreignent l’accès aux droits politiques des résidents. Par ailleurs, elle montre que ces pratiques excluantes ne se justifient pas dans un rapport explicite au droit mais bien dans l’ ignorance des législations qui encadrent les droits politiques. Sur cette base, nous recommandons une meilleure information des directions et du personnel de ces établissements concernant les droits politiques et davantage de dialogue social afin que s’élabore collectivement une véritable « conscience du droit » susceptible de garantir la citoyenneté des personnes âgées (et d’autres groupes de personnes institutionnalisées).
Une politique de promotion de la santé environnementale spécifique à destination des femmes enceintes, des jeunes enfants, et des professionnels qui les accompagnent
Authors: Morisson Claire
Published: November 2022

L’ ars Nouvelle Aquitaine développe une politique régionale innovante depuis 2014 visant à réduire les expositions des femmes enceintes et jeunes enfants (1000 premiers jours) aux perturbateurs endocriniens et autres substances chimiques présents dans les environnements intérieurs. En effet, de plus en plus de données montrent les liens entre ces expositions à des périodes sensibles et l’apparition de troubles de la santé et/ou de maladies chroniques. De nombreuses actions sont conduites pour sensibiliser, informer, former, éduquer tous les professionnels de santé et les professionnels de la petite enfance afin d’harmoniser les discours et les pratiques. Un seul objectif : adopter les bons gestes à la maison et dans tous les lieux d’accueil de ces publics (maternités et crèches notamment). Comment ? En rappelant le « bon sens » pour contribuer à modifier les habitudes : aérer, choisir des produits labellisés, adapter les clauses des marchés publics ou diffuser des outils pratico-pratiques pour accompagner tous les publics.
Analysis of a deterministic-stochastic oncolytic M1 model involving immune response via crossover behaviour: ergodic stationary distribution and extinction
Authors: Atangana Abdon , Rashid Saima
Published: November 2022

Oncolytic virotherapy is a viable chemotherapeutic agent that identifies and kills tumor cells using replication-competent pathogens. Oncolytic alphavirus M1 is a naturally existing disease that has been shown to have rising specificity and potency in cancer progression. The objective of this research is to introduce and analyze an oncolytic M1 virotherapy framework with spatial variability and anti-tumor immune function via piecewise fractional differential operator techniques. To begin, we potentially demonstrate that the stochastic system's solution is non-negative and global by formulating innovative stochastic Lyapunov candidates. Then, we derive the existence-uniqueness of an ergodic stationary distribution of the stochastic framework and we establish a sufficient assumption $ \mathbb{R}_{0}^{p} < 1 $ extermination of tumor cells and oncolytic M1 virus. Using meticulous interpretation, this model allows us to analyze and anticipate the procedure from the start to the end of the tumor because it allows us to examine a variety of behaviours ranging from crossover to random mechanisms. Furthermore, the piecewise differential operators, which can be assembled with operators including classical, Caputo, Caputo-Fabrizio, Atangana-Baleanu, and stochastic derivative, have decided to open up innovative avenues for readers in various domains, allowing them to encapsulate distinct characteristics in multiple time intervals. Consequently, by applying these operators to serious challenges, scientists can accomplish better outcomes in documenting facts.
Influence of Educational Video Games for the Achievement of the Mathematics and Problem-Solving Abilities of Upper Primary School Students
Authors: Praveen Kumar G.  , Vasimalairaja M.
Published: November 2022

This study examined post-test performance and retention performance of students in mathematics when learned and problem-solving ability through educational video games and traditional lecture method. The study adopted a quasi-experimental design. The sample was drawn from Alagappa Model Higher Secondary School in Karaikudi at Sivagangai district in southern Tamilnadu. Respondents were 90 students (46 boys and 44 girls). The findings revealed that there was a significant difference in the post-test scores, retention test scores, gender, and localities of experimental and control groups. The study concluded that educational video game learning significantly improves students' achievement and retention capacity. Therefore, the study recommended that this advent of learning that combines both face-to-face and online delivery can effectively be utilized in learning mathematics and problem solving to enhance the performance and retention among upper primary school students.
Photography Education in Resource-Constrained Contexts
Authors: Khoza Bongani Joseph , Tshuma Nompilo
Published: November 2022

The history, development, products, and impact of image-making are well-represented in literature. The literature looks extensively at the technological developments and advancements in the field and how photography has contributed to our understanding of historical, political and social tensions. However, the training and preparation of photographers has received less attention in the literature, particularly in photography education in resource-constrained contexts. This paper seeks to present mushfaking as a conceptual framework that addresses the multi-literacies required in photography education. This approach uses inexpensive solutions to aid digital photography's teaching and learning process. Mushfaking is offered as a learning design tool for practice-based teaching and learning. The paper aims to offer a new dimension on how mushfaking can be used as a learning design principle to show how this concept could bring theory and praxis together, facilitating the design of context-based solutions to educational problems.
Management Consulting Analysis and Applications of Adaptive Marketing and Organizational Strategy During COVID-19
Authors: Lewis Eugene , Burrell Darrell Norman , Richardson Kevin
Published: November 2022

This management consulting case study on adaptive marketing during COVID-19 in the real estate industry focuses on the overvaluation of housing utilizing horizontal diversification changes across demographics. Horizontal diversification is described as adding new products to an existing brand that targets existing consumers. The management consultants engaged in an action research analysis of Moreso Real Estate during COVID-19 as the organization seeks to discover innovative ways to penetrate the real estate market. Although COVID-19 still poses many challenges for businesses, this organizational development action research seeks to uncover practices in which businesses still face questions of how to meet the demand of the market. The management consulting organizational development framework utilized include the Ansoff Matrix and Balanced Scorecard Model. The intent is to influence the world of practice by providing viable strategies and recommendations from a real-world perspective.
Circuit Implementation of Respiratory Information Extracted from Electrocardiograms
Authors: Cheng Shi , Zhang JinBao , Gao Zhan , Wang Jiehua
Published: November 2022

Breathing is an important physiological process in the human body. The wavelet transform method can extract respiratory information from electrocardiogram (ECG) data; thus, the authors designed an integrated circuit of ECG-derived respiration (EDR). They propose a discrete wavelet transform (DWT) EDR algorithm based on an analysis of the heartbeat frequency and respiration. They verified the algorithm in both the time domain and the frequency domain using Matlab. Next, the DWT EDR digital circuit was designed using the QUARTUS program. Finally, they used a field programmable gate array (FPGA) for downloading and simulation, and they verified the designed circuits using a logic analyzer, where they compared the waveform of the data obtained from the EDR circuit with the waveform obtained after processing the wavelet transform EDR in Matlab. The experimental results showed that the circuit can allow the extraction of respiratory information from ECG data.
Significance of Trait Inferences on Applicant Attraction: A Study of the Indian Information Technology Sector
Authors: Kavitha M. , Srinivasan P. T.
Published: November 2022

All the business units are in a tussle to build a competitive brand not only to increase the market share but also to capture the potential applicants. It is believed that customers assign certain qualities to each and every brand they know. Similarly, potential applicants attach specific traits to the organizations, which in turn influence their attitude towards the organization. The present study attempts to examine the perception of external audience towards symbolic traits and employer attractiveness in the Indian Information Technology (IT) Sector. Two samples of prospective applicants were drawn (Students = 351, IT Employees = 234) from the applicant population. Respondents were randomly assigned to respond about two leading IT companies, chosen for the study. Results of multiple regressions reveal that the symbolic attributes significantly predict the level of attractiveness of an organization, with dimensions like competence and sophistication playing an important role as major predictors for both the samples. Students, being a naïve job seeker, considered excitement as another key predictor for attractiveness. Based on the results implications for practice are discussed.
How has “Management of Ba” been developed? Itami’s research from Management control systems to Management of Ba
Authors: Inoue Kenji , Suzuki Kenichi
Published: November 2022

This research aims to reveal the background of the “management of ba” (a Japanese term meaning “field”), which is proposed by Hiroyuki Itami, because his research has been shifted from management control systems to management of ba. We review Itami’s articles from the 1970s to the present to clarify why Itami created the management of ba. Itami revised his assumption of the organization to describe real-life management practices based on his research results. In addition, it was important to investigate how Itami’s assumption of human nature had shifted to include individuals’ autonomy and self-organization, key aspects of the management of ba. A management approach that enhances psychological energy is needed in order to increase individuals’ autonomy and self-organization. That approach is indeed refers to the management of ba. By reviewing Itami’s research, we identified that Itami’s research question was, “how can the liberty of an individual be ensured within an organization?” Itami noted that management control systems need to balance liberty and discipline; thus, we focused on the problem of the liberty of individuals in organizations from the point of view of management accounting research.
Patient-Reported Outcomes at Return to Sport After Lateral Ankle Sprain Injuries: A Report From the Athletic Training Practice-Based Research Network
Authors: Lam Kenneth C. , Marshall Ashley N. , Bay R. Curtis , Wikstrom Erik A.
Published: November 2022

Context

Limited evidence exists regarding the assessment of single-item patient-reported outcomes when patients are medically cleared to return to sport after a lateral ankle sprain (LAS) injury.

Objective

To evaluate self-reports of improvement in health status, pain, function, and disability at return to sport after an LAS.

Design

Descriptive study.

Setting

Sixty-nine athletic training facilities across 24 states.

Patients or Other Participants

A total of 637 patients (males = 53.2%) who were diagnosed with an LAS, restricted from sport after injury, and subsequently medically cleared to return to sport within 60 days were included.

Main Outcome Measure(s)

Descriptive statistics were used to summarize scores for health status (Global Rating of Change), pain (Numeric Pain Rating Scale), function (Global Rating of Function), and disability (Global Rating of Disability). Mann-Whitney U tests were used to compare score differences between sexes. A Kaplan-Meier analysis was performed to provide a visual depiction of sex differences in the time to return to sport.

Results

Most patients sustained an LAS injury while participating in basketball, football, or soccer and were cleared to return to sport 8 days after injury. More than two-thirds of patients reported a meaningful improvement in health status between the time of injury and return to sport. However, many noted deficits related to pain (65.1%), function (86.2%), or disability (35.8%) at return to sport. No differences were seen between males and females for pain (P = .90), function (P = .68), change in health status (P = .45), or disability (P = .21) at return to sport, although males returned to sport slightly sooner than females (P = .025).

Conclusions

Despite self-perceived improvements in health status since the time of injury, patients typically returned to sport with deficits in pain, function, and disability after an LAS. Patients may be returning to unrestricted sport participation before they feel their bodies have fully recovered from the injury.
The Clinical Diagnostic Utility of Array CGH in Children with Syndromic Microcephaly
Authors: Goyal Manisha , Faruq Mohammed , Gupta Ashok , Shrivastava Divya , Shamim Uzma
Published: November 2022

Background:

A prospective study using array CGH in children with Syndromic microcephaly from a tertiary pediatric healthcare centre in India.

Aim:

To identify the copy number variations causative of microcephaly detected through chromosomal array CGH.

Patients and Methods:

Of the 60 patients, 33 (55%) males and 27 (45%) females who consulted the Rare Disease Clinic at Department of Pediatrics, SMS Medical College, Jaipur, with developmental delay/facial dysmorphism/congenital anomalies in combination with microcephaly were included.

Exclusion Criteria:

Children with acquired or non-genetic causes of microcephaly, craniosynostosis, metabolic diseases, known chromosomal aneuploidy such as trisomy 21, 13, and 18 and abnormal karyotype were excluded. The cohort was analyzed by array CGH in order to identify potentially pathogenic copy number variants (CNVs).

Results:

Clinically relevant pathogenic or likely pathogenic copy number variations (CNVs) were identified in 20/60 (33.3%) patients, variant of uncertain significance (VOUS) in 4/60 (6.6%) cases and benign CNVs in 3/60 (5%) of total cases. Out of 20 cases with pathogenic CNVs, 12 (60%) patients detected with a deletion, five (25%) patients with duplication and three (15%) patients resulted with a complex chromosomal rearrangement. Twelve cases present CNVs containing genes known to be implicated in microcephaly etiology.

Conclusion:

This research highlights the contribution of submicroscopic chromosomal changes in the etiology of microcephaly in combination with developmental delay/facial dysmorphism/congenital anomalies (syndromic microcephaly). Our studies provide more insights into the benefits derived by using array CGH analysis in patients with syndromic microcephaly.
Ventilator-assisted priming of an anaesthesia circuit (VAP technique): An exploratory study
Authors: Ali Muhammad S. , Aamir Rahila
Published: November 2022

Background and Aims:

The speed of inhalational induction depends on a variety of factors, of which priming the breathing circuit with volatile anaesthetics plays a vital role. This study compared ventilator-assisted priming (VAP) and a passive priming technique using different fresh gas flows (FGFs) in neonatal, paediatric, and adult anaesthetic circuits.

Methods:

In both techniques, FGF with 100% oxygen and 8% sevoflurane vaporiser concentration were set at 2 Lmin-1, 4 Lmin-1, and 8 Lmin-1, representing three groups FGF-2, FGF-4, and FGF-8, respectively. The time taken to achieve 6% sevoflurane concentration at the patient end of the circuit was measured. In addition to this, we explored various combinations of tidal volumes and respiratory rates in the VAP technique and recorded the priming time with each combination. The amount of sevoflurane consumed for priming in both techniques was also calculated.

Results:

VAP was three times faster than passive priming in all the FGF groups in the three circuits. In the VAP technique, the shortest priming times were similar for FGF-4 and FGF-8 (P > 0.05) but were significantly higher for FGF-2 (P = 0.001) in the three circuits. Sevoflurane consumption did not differ in FGF-2 and FGF-4 groups, whereas it doubled in the FGF-8 group using the VAP technique in all three circuits.

Conclusion:

The VAP technique provides a quick and effective method for priming to achieve a high anaesthetic concentration within the breathing circuit for inhalational induction.
Safety of uro-oncology practice and robot-assisted surgery during the peak of COVID-19 pandemic
Authors: Dev Preetham , Yuvaraja T. B. , Waigankar Santosh S. , Ranade Sharmila , Pednekar Abhinav P. , Agarwal Varun , Khandekar Archan , Badlani Naresh , Asari Ashish
Published: November 2022

Aim:

The pandemic by novel coronavirus disease 2019 (COVID-19) is the biggest threat to global health care. Routine care of cancer patients is affected the most. Our institute, situated in Mumbai, declared as the hotspot of COVID-19 in India, continued to cater to the needs of cancer patients. We did an observational study to review the experience of managing uro-oncology patients and who underwent either open, endoscopic, or robot-assisted surgery for urological malignancy.

Materials and Methods:

During the peak of COVID-19 pandemic from March 21, 2020, to June 21, 2020, all the uro-oncology cases managed in our tertiary care hospital were analyzed. Teleconsultation was started for follow-up patients. All patients requiring surgery underwent reverse transcription-polymerase chain reaction for COVID-19. Institutional protocol was formulated based on existing international guidelines for patient management. Adequate personal protection and hydroxychloroquine prophylaxis were provided to health-care professionals.

Results:

During the study period, 417 outpatient consultations were made. Forty-nine patients underwent surgery for different urological malignancies. Majority of the surgeries were robot-assisted surgeries (59.2%, 29 patients), followed by endoscopic procedures (28.5%, 14 patients) and few open procedures (10.2%, five patients). Most of our patients were elderly males (mean, 62.5 years). With a median follow-up of 55 days (interquartile range, 32–77), there was no report of COVID-19 infection in any patient or health-care provider.

Conclusions:

We can continue treating needy cancer patients with minimal risk by taking all precautions. Our initial experience of managing uro-oncology cases during this pandemic is encouraging. Robotic surgeries can be safely performed.
A randomized study for dosimetric assessment and clinical impact of bone marrow sparing intensity-modulated radiation therapy versus 3-dimensional conformal radiation therapy on hematological and gastrointestinal toxicities in cervical cancer
Authors: Kapoor Ankita Rungta , Bhalavat Rajendra L , Chandra Manish , Pareek Vibhay , Moosa Zaiba , Markana Saurabh , Nandakumar P. , Bauskar Pratibha , Shincy N. V.
Published: November 2022

Background:

Cervical cancer requires multimodality therapy, resulting in acute toxicities. Intensity-modulated radiation therapy (IMRT) is postulated to spare bone marrow (BM) and bowel to reduce acute hematological and gastrointestinal (GI) toxicities of chemoradiotherapy.

Patients and Methods:

This is a prospective randomized phase III study enrolling patients with Stage IB to IVA cervical carcinoma in two arms receiving either three-dimensional conformal radiotherapy (3DCRT) or IMRT from December 2017 to December 2019. The primary objective was to compare the hematologic toxicities (Grade 2 or more neutropenia as the primary factor) and the secondary objectives were to compare GI toxicities, and dosimetric analysis for volumes of BM, and bowel irradiated. SPSS version 20 was used for all statistical calculations.

Results:

Eighty patients with histopathologically confirmed cervical cancer were randomized to receive IMRT or 3DCRT (40 in each arm). The median age of the patients was 56.5 (36–67) and 59.5 (37–68) years, respectively, in IMRT and 3DCRT arms. The median dose of external radiation was 50 Gy in 25 fractions, and of brachytherapy was 24 Gy in 3 fractions in both the arms. The incidence of grade ≥2 neutropenia was 42.5% and 15% in the 3DCRT and IMRT arms, respectively (P < 0.001). All patients received concurrent chemotherapy with cisplatin, with the median number of cycles being 5 (range 3–5) in both the arms. All five cycles of concurrent chemotherapy could be completed in 25 (62.5%) patients in the IMRT arm and 24 (60%) patients in the 3DCRT arm.

Conclusions:

IMRT significantly reduces acute hematologic and GI toxicities compared with 3DCRT with a better dosimetry profile.
Development and validation of an indigenous, radiobiological model-based tumor control probability and normal tissue complication probability estimation software for routine plan evaluation in clinics
Authors: Patel Ganeshkumar , Mandal Abhijit , Bharati Avinav , Choudhary Sunil , Mishra Ritusha , Mourya Ankur
Published: November 2022

Purpose:

Development and validation of a simple and convenient computational program in MATLAB environment for estimating the tumor control probability (TCP) and the normal tissue complication probability (NTCP), as a decision support system for routine plan evaluation.

Materials and Methods:

We developed an in-house software using MATLAB 2016b (Mathworks) for estimating TCP and NTCP named as RBMODELV1. The program contains Niemierko free equivalent uniform dose (EUD) program code provided in authors research article. For rest of radiobiological (RB) models in the software separate coding is performed. The program accepts cumulative dose–volume histogram file in (.txt) format containing two columns dose and volume. A set of two RB parameters were prepared, default and user-dependent in excel sheet named as RBDATA. We cross-validated results of RBMODELV1 software with BioSuite software for Poisson's TCP model and Lyman-Kutcher-Burman (LKB) model. A set of total 20 patient's data of head and neck site took under study and respective TCP and NTCP calculated by all the RB models and compared.

Results:

This is the first study in which we tried to establish correlation between the mean doses (EUD) received by parallel structure (parotid gland and oral cavity) and predicted percentage of NTCP values. It is found that mean dose in the range of 35–40 Gy for parotid gland can result in more than 50% NTCP predicted by all four RB models. Similarly oral cavity receiving mean dose in the range of 53–58 Gy can results in more than 35% NTCP predicted by all the four models. There is <3% variation observed between TCP calculated by BioSuite and RBMODELV1 software and <4% variation observed between predicted NTCP for parotid gland and oral cavity OAR from LKB model by both the software.

Conclusion:

We created simple software RBMODELV1 which can be used as a research tool as well as decision support system.
Dysregulated claudin expression significantly effect breast cancer disease progression
Authors: Fatima Zunaira , Riaz Syeda Kiran , Khan Jahanghir Sarwar , Haq Farhan , Malik Muhammad Faraz Arshad
Published: November 2022

Background:

In this study, the role of claudins in cancer progression was explored among breast cancer-affected women.

Methodology:

Two cohorts (discovery and validated) of breast cancer-affected women were used. In discovery cohort, 90 freshly excised breast tumor tissues along with adjacent cancer free specimens were collected at the time of surgery. These specimens were processed for RNA isolation and complementary DNA synthesis. After designing primers for claudin 3, claudin 4, and claudin 7, these sequences were synthesized from Macrogen, Korea. Claudin expression in respective tumors and controls was assessed using quantitative reverse transcription polymerase chain reaction. Any probable correlation of these molecules with various clinicopathological parameters was explored. For validation, a publicly available dataset of 2088 breast cancer patients was accessed. Claudin expression of these patients was analyzed for given clinical parameters and compared with earlier findings of discovery cohort.

Results:

Discovery cohort comprised 17% luminal A, 63% luminal B, 8% human epidermal growth factor receptor 2 enrich, and 12% triple-negative breast cancer tumor. High claudin 3 expression was significantly correlated with tumor size >2 cm and menopausal status. Claudin 7 expression was upregulated among poorly differentiated tumor patients. Both claudins 3/4 showed significant correlation with tumor grade, stage, size, and metastasis. Claudin-low subtype was also found in 18% of the cohort.

Conclusion:

Claudins impart a significant role in cell differentiation and disease progression. Hence, claudin cluster can be ascertained as the disease biomarkers for breast cancer.
Dual Tumors — Trichoadenoma of Nikolowski and Melanocytic Naevi
Authors:   Department of Pathology, RV Metropolis Diagnostic and Healthcare Pvt. Ltd, Bangalore, Santosh K V , Manjunath K N , Ravikumar Vani , Ravikumar H N
Published: November 2022

Trichoadenoma is a rare benign tumor with differentiation to hair follicle. There are several reports of a melanocytic naevus seen in association with another benign adnexal tumor with hair follicular differentiation - trichoepithelioma. However, there is, to the best of our knowledge, only one case of a collision tumor of trichoadenoma with a melanocytic naevus - with an admixture of the two components. Trichoadenoma and trichoepithelioma are considered parts of a spectrum, with trichoadenoma being better differentiated than trichoepithelioma. Herein we present an unusual case of dual tumors - trichoadenoma and melanocytic naevi of the face. Unlike the previously reported case, the current case had simultaneous occurrence of trichoadenoma and naevi at different locations. The exact cause for the association of these tumors - trichoadenoma and melanocytic naevi - is uncertain. Key Messages : Benign dermal adnexal tumors like trichoepithelioma and trichoadenoma may be found in association with melanocytic naevi. Keywords: Dermal adnexal tumor, Trichoadenoma, Melanocytic Naevi
Chocolate Stick Causing Concealed Intestinal Perforation with no Signs of Peritonitis in a Child: A Case Report
Authors:   Department of General Surgery, Government Institute of Medical Sciences, Greater Noida, 201310, UP,, Baidya Manabendra , Kumar Satendra , Singh Ankur Deep , Pandey Sandeep Kumar , Giri Samaksh
Published: November 2022

To highlight a very uncommon presentation of intestinal perforation in a child caused due to foreign body. 10-year-old kid presented to the emergency with chief complains of pain abdomen for 2 days. There was no evidence of any peritonitis. X-ray and Contrast enhanced computed tomography scan revealed no pathology other than gas under diaphragm. On exploration there was a concealed perforation caused due to chocolate stick ingested by the kid. There was no free fluid or contamination found in the peritoneal cavity. Foreign body ingestion by kids is very common. 80-90 % these objects pass with stool not causing any injury to the viscera. In 10 to 20 % cases they require endoscopic removal. 1 % of these cases can cause perforation and have to be removed surgically. Majority of the times these foreign bodies are not seen on X-rays or CT scans. There may be cases in which patients may not present with features of perforation peritonitis but still patients must be assessed properly to undertake intervention at appropriate time to reduce complication. In such children presenting to emergency with acute pain abdomen, a high degree of suspicion for foreign body ingestion should be kept in mind and evaluated accordingly. Keywords: Concealed perforation, Pediatric age group, No signs of peritonitis, X-ray, CECT Whole abdomen
Détours existentiels et impasses postcoloniales dans Half A Life de V.S. Naipaul
Authors: MULLA Ahmed
Published: November 2022

Dans ses « enquêtes » comme dans son œuvre fictionnelle, le Prix Nobel de littérature V.S. Naipaul s’est évertué à chercher ce qui dans les entreprises postcoloniales a fait basculer l'histoire, grande ou petite, du rêve au cauchemar. Son pénultième roman, Half A Life (La moitié d'une vie), décrit précisément le délitement d'une société coloniale portugaise sur la côte orientale du continent africain. Alors que la critique s’est surtout intéressée aux chapitres situés en Inde et en Angleterre, nous proposons d’analyser la dernière partie du roman, celle où le protagoniste indien découvre le monde complexe de la colonie, un monde anachronique où la ligne de démarcation entre colons et autochtones ne cesse d'apparaître plus clairement à ses yeux.
L’entre-lieu du discours latino-américain
Authors: SANTIAGO Silviano , HEINEBERG Ilana
Published: November 2022

Dans cet essai publié en portugais pour la première fois en 1978 mais écrit en français en 1971 et publié en anglais en 1973, l’auteur propose le concept d’« entre-lieu » pour réfléchir à la situation d’énonciation de l’écrivain latino-américain et à la dépendance culturelle des pays colonisés. Il reprend la métaphore de l’anthropophagie d’Oswald de Andrade (1928) et fait de l’entre-lieu un espace de transgression, d’appropriation, voire de décolonisation du regard.
La référence descriptive comme forme de positionnement de l’être Noir
Authors: LARANJEIRA Pires , DOS SANTOS Barbara
Published: November 2022

Le présent article est la traduction d’un extrait de la thèse de doctorat de J. L. Pires Laranjeira, éminent spécialiste des littératures africaines de langue portugaise, qui porte sur la Négritude africaine de langue portugaise. Cet extrait se concentre sur l’analyse du discours du Noir et de ses spécificités dans les textes négritudinistes de langue portugaise, à travers une réflexion sur les univers symboliques et référentiels qui les composent.
Entre Prospero et Caliban : colonialisme, postcolonialisme et interidentité
Authors: DE SOUSA SANTOS Boaventura , AMORIM Silvia
Published: November 2022

Si l’identité occidentale moderne résulte en bonne partie du colonialisme, dans l’espace de la langue portugaise elle reflète les particularités du colonialisme portugais. Il s’agit d’un colonialisme subalterne, lui-même « colonisé » dans sa condition semi-périphérique, dont la compréhension échappe à la pensée postcoloniale des pays centraux, basée sur le colonialisme hégémonique. Nous proposons dans cet essai le concept d’interidentité afin de figurer cette construction identitaire complexe, contenant à la fois des traces de colonisateur et de colonisé. Le manque et la nostalgie de l’hégémonie ont favorisé le développement de colonialismes internes qui perdurent aujourd’hui encore. Au vu de ces éléments, l’auteur conclut que le postcolonialisme portugais doit se manifester, à l’ère de la globalisation néolibérale, comme anticolonialisme et comme mondialisme contre-hégémonique.
Déclinaisons post(-)coloniales à la portugaise ? Théorie postcoloniale et culture nationale au Portugal
Authors: CAHEN Michel
Published: November 2022

Les diverses générations postcoloniales (études subalternes, études postcoloniales, études décoloniales, épistémologies du Sud) ont eu des origines territorialisées (Inde, États-Unis, Australie, Royaume-Uni, Amérique andine, Portugal) qui, malgré l’objectif transnational affiché, ont eu des conséquences importantes sur les contenus. Le Portugal est une étude de cas intéressante pour examiner si la pensée postcoloniale qui s’y est développée a été, ou non, en rupture avec la culture nationale post-impériale du pays. En particulier, la pensée de Boaventura de Sousa Santos est un bon exemple pour démontrer, en dépit d’une radicalité apparente, le maintien de traits essentiels de la tradition nationale, mélangée à un héritage postmoderne.
Modelo de gestión del proceso de desarrollo de productos para pequeñas y medianas empresas productoras de alimentos
Authors: Rossetti Germán Horacio , De Greef Melisa
Published: November 2022

La Gestión del Proceso de Desarrollo de Productos (PDP) conlleva la realización de un conjunto de actividades, en las que deben intervenir la mayoría de las áreas funcionales de una organización. Cada una de estas actividades se lleva a cabo teniendo en cuenta el producto a desarrollar, la capacidad productiva, la estrategia comercial y la concepción filosófica de la empresa. En sectores competitivos, como el alimenticio, resulta indispensable contar con procesos que permitan mantener y conquistar nuevos mercados. Es por ello, que es de suma importancia hacer hincapié en el PDP para generar nuevos productos o modificar los ya existentes. En el presente trabajo se propone un modelo de Gestión del Proceso de Desarrollo de Productos para Pequeñas y Medianas Empresas Productoras de Alimentos pertenecientes a la zona del Gran Santa Fe. Para diseñar dicho modelo, se tuvieron en cuenta los modelos referenciales de Rozenfeld (2006) y Penso (2003), así como también los parámetros característicos de las empresas del sector (tamaño, estructura organizacional, ambiente laboral y cultural de sus recursos humanos, etc.). En primer lugar, se llevó a cabo una búsqueda bibliográfica que permitió elaborar una serie de variables y categorías para diagnosticar la situación del PDP en las organizaciones. Luego, se realizaron 17 entrevistas semi-estructuradas a empresas productoras de alimentos de la región seleccionada y, a partir de la información obtenida, se definió el nivel de madurez del PDP en cada una de ellas. En función de los resultados alcanzados y los modelos referenciales mencionados, se elaboró el Modelo de Gestión de Desarrollo de Productos.
Globalización, TIC y Educación Superior: trilogía para un análisis internacional desde un enfoque de ciencia, tecnología y sociedad
Authors: Joao Pedro Antonio Joaquim
Published: November 2022

El objetivo del presente trabajo es realizar una referencia actualizada de autores que abordan la temática referida a la relación que se establece entre la trilogía: Globalización, TIC y Educación Superior, desde una mirada de Ciencia, Tecnología y Sociedad.  Para ello se parte del fenómeno actual de la globalización que ocurre con el desarrollo de las tecnologías y el impacto que tiene en los sistemas educativos en general particularizando la universidad contemporánea. También se analizan temas de actualidad como es la Brecha Digital existente entre países con diferentes niveles de desarrollo, el reto de incorporar las TIC en las universidades a partir de los componentes humanos y tecnológicos necesarios. De igual forma se aborda los problemas asociados al uso indebido de las tecnologías y su impacto social, educativo y ético. Uno de los elementos más significativos que se evidencian es el proceso de transición de la sociedad de la información hacia una nueva sociedad de la inteligencia, vista esta última como un proceso donde la información es evaluada por los usuarios de las redes telemáticas. Se demuestra la necesidad de capacitar a profesores y estudiantes en función de incorporar las TIC en la universidad de forma consciente, planificada y eficiente.
SOFTWARE GUIDED NAVIGATION OF CORONARY WIRE FOR CHRONIC TOTAL OCCLUSION RECANALIZATION: A BENCH STUDY OF NAVIWIRE APPLICATION
Authors: Suleman Muhammad
Published: November 2022

Objectives: Chronic Total Occlusion usually requires specialized wires. These specialized wires should not be rotated haphazardly and as this can lead to rotation of wire inside subintimal space and leading to creation of large subintimal space and collapse of main lumen and making difficult wire reentry. Only controlled and intentional rotation of wire is necessary for higher procedural success. Coronary arteries are 3 dimensional structures and fluoroscopy has limitation to locate the wire in three dimensional vessels.  3D wiring is one method for accurate guidewire location in CTO lesions. Previously some authors have proposed methods to make a mental picture of 3D wiring.  In order to make this process even less cumbersome. We propose a software application named NAVIWire that does the job in cath-lab with in two steps. The purpose of this study is to assess the accuracy of our software to locate a wire shaft and tip inside 3D printed coronary vessel.

Methodology: A 3D printed coronary vessel is printed in such a way that it is divided into 9 quadrants. One operator inserted wire into one of these quadrants. The wire had 1mm tip bend like use in CTO. This operator knew the location of wire and tip orientation. Operator 2 (first time user) and operator (expert user) who were blinded to original location imaged this model under biplane fluoroscope using LAO 45 and RAO 45. The process was repeated 36 times and randomly the first operator changed the location and orientation of tip each time. They inserted the data from these two views into the NAVIWire software and it output the predicted location of wire in these quadrant and tip orientation. We compared this predicted location with original location. We also reported inter-observer variability between first time user and expert user. In addition, we also reported a case of successful crossing of LAD CTO using NAVIWire software. This case report will help operators understand the usage of NAVIWire in real life settings.

Results: The location of wire shaft inside all 9 quadrants was 100% correctly predicted by all operators. Although the expert user (operator 2) correctly predicted the tip orientation all 36 times but first time user predicted with 94.4% accuracy. The case report of patient shows successful crossing of CTO wire using NAVIWire assisted 3D wiring.

Conclusion: NAVIWire correctly predicts CTO wire location and tip orientation in 3D printed coronary vessel and the case report also reiterate the finding in real life setting.
COMPARISON OF CLINICAL OUTCOMES OF CALCIFIED AND NON-CALCIFIED CORONARY ARTERY LESION INTERVENTION UNDER IVUS GUIDANCE -AN EXPERIENCE FROM A SOUTH ASIAN COUNTRY, PAKISTAN
Authors: Ihsanullah Ihsanullah , Rahman Nasir , Nasir Ayesha , Adnan Ghufran , Farhad Awais , Saeed Yawer , Khan Maria
Published: November 2022

Objectives: Intralesional coronary artery calcification (CAC) is an important prognostic marker in terms of target lesion failure, target vessel revascularization and clinical outcomes. Intravascular ultrasound (IVUS) plays a pivotal role in the optimal management of calcified coronary arteries. We aimed to determine the clinical outcomes of IVUS guided intervention of calcified coronary lesions in a South Asian country.

Methodology: We retrospectively studied a total of 134 consecutive patients, who underwent IVUS guided assessment of coronary arteries from January 2013 to March 2020 at a single center. Patients were categorized into two groups: those with coronary artery calcification (CAC, n=77) and without coronary artery calcification (non-CAC, n=57). The mean duration of follow-up was 40.3 ± 30.1 months. The two groups were compared based on their clinical characteristics, management, in-hospital events, follow-up, and major adverse cardiac events (MACEs) that included cardiovascular death, non-fatal MI, life-threatening arrhythmia, bleeding, heart failure, stroke, and target vessel revascularization.

Results: A total of 134 patients were included who had undergone IVUS and were divided into two groups patients with CAC (n=77) and non-CAC (n=57). Majority of the patients were male (n=97 [72.3%]), the mean age at presentation was 63.1 ± 12.9 years. In CAC group the most common risk factor was Age of the patient then dyslipidemia (n=68[88%] followed by hypertension (n=64[83%]) and diabetes mellitus (n=44[57%]), CAC group patients were more commonly presented with acute coronary syndrome (n=59[76.6%]), had prior PCI (n=40[52%]), had more LM disease (n=34 [44%], p=value 0.005), significant number of prior stent-ISR (n=27[47%]) p=0.024. Having CAC is associated with higher MACE (17 out of 26 events).

Conclusion: Patients with CAC have more comorbidities and more commonly present with acute coronary syndrome. MACEs were recorded higher in the CAC group although the results are not statistically significant.
The Legal Effectiveness Limitation on Freedom of Movement in According to Overcoming the Spread of Covid-19 Pandemic in Indonesia
Authors:   Master of Law Program, Faculty of Law, Muhammadiyah Malang University, Ihsan Firdaus Muhammad
Published: November 2022

The Covid-19 pandemic has been spread throughout the world, which has caused the governments of each country to implement a restriction on human rights, which is freedom of movement. This is a step and a response from the government to overcome the spread of Covid-19, as well as the Indonesian government. As a state of law (rechtstaat), of course the Indonesian government has its own specialty to respond and to enforce a regulation to deal with di Covid-19 pandemic, in accordance with the provisions of the emergency constitutional law and the limitation on human rights. The limitation on freedom of movement throughout the implementation of limitation on human rights that have been implemented by the Indonesian government, if it traced, they are PSBB, Transitional PSBB, Emergency PPKM and 4-Level PPKM. These are all of the responses and steps that have been taken by the government to cope and to overcome the Covid-19 pandemic. However, of course, the implementation is not always in accordance with what is expected, so it is worth questioning the legal effectiveness, whether it is in accordance with the sense of justice as the law is implemented, or not in accordance and far-reached from the sense of justice as one of the objectives of the law.
Industry perspectives of industry school partnerships: What can agriculture learn?
Authors:   CQUniversity Australia, O'Dea Molly , Cosby Amy , Manning Jaime , McDonald Nicole , Harreveld Bobby
Published: November 2022

This paper aims to identify and synthesise research related to industry perspectives of industry school partnerships (ISPs) with primary and secondary students globally. A systematic review of ISP studies published between 2001 and 2021 that included industry perspectives was undertaken in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. This focused systematically ordered review of industry perspectives of ISPs elicited four key findings: Limited research specifically focusing on industry participants’ perceptions of career and knowledge sharing ISPs exist. The most common reasons for participation included promoting careers and/or their industry, and enhancing community goodwill. The most common barriers or challenges in participating included time, budget and process constraints, and understanding the partnership’s impact. Communication, trust, relationships, and setting clear goals are often important features highlighted for successful partnerships. The recommendations from this review will be used to design, deliver and evaluate ISPs which aim to benefit agricultural industry participants. Future research will apply the findings from this review to a rural case site in Victoria, Australia, focused on agricultural ISPs aimed at increasing students’ aspirations for a career in the sector. This is vital as agriculture is an important industry in this region, yet many students are unaware of the range of career opportunities available to them.