bluuebunny/crossref_metadata_2025 huggingface dataset:
Time-resolved small RNA transcriptomics of the ichthyosporean Sphaeroforma arctica
Authors: Ondracka Andrej , Dudin Omaya , Bråte Jon
Published: May 2023

Ichthyosporea, a clade of holozoans, represent a clade closely related to animals, and thus hold a key phylogenetic position for understanding the origin of animals. We have previously discovered that an ichthyosporean, Sphaeroforma arctica, contains microRNAs (miRNAs) as well as the miRNA processing machinery. This was the first discovery of miRNAs among the closest single-celled relatives of animals and raised intriguing questions about the roles of regulatory small RNAs in cell development and differentiation in unicellular eukaryotes. Like many ichthyosporeans, S. arctica also undergoes a transient multicellular developmental life cycle. As miRNAs are, among other roles, key regulators of gene expression during development in animals, we wanted to investigate the dynamics of miRNAs during the developmental cycle in S. arctica. Here we have therefore collected a comprehensive time-resolved small RNA transcriptome linked to specific life stages with a substantially higher sequencing depth than before, which can enable further discovery of functionally relevant small RNAs. The data consists of Illumina-sequenced small RNA libraries from two independent biological replicates of the entire life cycle of S. arctica with high temporal resolution. The dataset is directly linked and comes from the same samples as a previously published mRNA-seq dataset, thus enabling direct cross-functional analyses.
Evaluation and comparison of the effectiveness of kaleidoscope and virtual reality goggles to reduce dental anxiety in young children undergoing administration of local anesthesia.
Authors: Parakh Himani , Thosar Nilima
Published: May 2023

Administration of local anesthesia via injection is the main reason for inducing anxiety in children and if not intervened it aggravates the anxiety in subsequent appointments. There are many approaches, including pharmacological and non-pharmacological methods that can be used to reduce children's perception of pain and anxiety. A frequently used non-pharmacological behaviour management method to reduce anxiety and procedure pain is distraction. The rationale of distraction is to shift the attention to avert the brain from receiving unwanted stimulus which induce anxiousness. Many approaches including music, television, portable video games, virtual reality (VR) helmet, and virtual reality audio-visual eyewear, have been implemented so far.  Kaleidoscope and virtual reality goggles may help as distraction techniques in reducing the levels of anxiety caused during administration of local anesthesia. By the aid of which the operator may be able to make the dental experience child friendly and ultimately provide quality dental care to anxious children. Non pharmacological measures of reducing pain are cost effective and best means that can be used while performing dental procedures. This is a research protocol for a study aimed to evaluate and compare the effectiveness of kaleidoscope and virtual reality goggles to reduce dental anxiety in young children.
Offering Memories to Sell Goods? Pricing and Welfare Implications of Experiential Retail
Authors: Mutlu Nevin , El-Amine Hadi , Sahin Ozge
Published: May 2023

Problem definition: In an environment where consumers’ rising valuation of Instagrammable memories drives their spending from products to experiences, retailers offer experiences to attract consumers back to their stores. Yet, it is not obvious under which settings consumers can benefit from these experiences and raise retailers’ profits. Methodology/results: We use a random utility model for consumer choice in both monopoly and duopoly settings. For the latter, we pose a game-theoretic model to analyze the equilibrium prices, profits, and consumer welfare for various problem cases. We show that medium-quality experiences can lower the product sales and store traffic below the level when no experience is offered. Sufficiently low- or high-quality experiences overcome this issue, making the consumers better off. Yet, the former presents the only profitable option when a single retailer in the market offers an experience. In contrast, when both retailers adopt experiences, low-quality experiences may not be profitable, and the retailers would need to adopt even higher-quality experiences, which lead to a “win-win-win” outcome for the two retailers and consumers. A fee structure for the experience elevates retailer profits but can turn stores into outlets where consumers visit to purchase experiences and not products. When experiential retailing is the common practice in the market, it enables “win-win-win” outcomes when free experiences fail. Managerial implications: Being the first to study this new retail format, our results contribute to the ongoing debate on the settings under which experiential offerings are beneficial for the retailers and consumers and highlight that there is no one-size-fits-all strategy. Our results show that experiences affect main product sales in nonobvious ways, especially in competitive markets. In a (post-)pandemic world where retailers try to attract consumers back to stores, we offer insights that can guide retailers in the process.

Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2021.0339 .
Student Employees’ Dropout Intentions: Work Excuse and University Social Capital as Source and Solution
Authors: Toyon Mohammad Abu Sayed
Published: May 2023

This study seeks to investigate the relationship between dropout intent, the weekly work duration of student employees, and university social capital by analysing empirical evidence from three European countries, including Estonia, Lithuania, and Poland. This exploratory study utilised Eurostudent-VII survey data and employed cross-tabulation and exhaustive Chi-square Automatic Interaction Detection (CHAID) to achieve its objectives. Findings indicate that student employees who believe they get along well with their teachers and have more connections with fellow students to discuss subject-related issues are less likely to intend to drop out of university. In addition, the results show that students’ likelihood of abandoning their higher education increases in the presence of difficulties caused by an inapt academic programme. Regarding employment duration, for the Estonian and Lithuanian markets, there is no difference between working more than 20 hours per week or less than that with the intention of dropping out of university. In Poland, however, the disparity in working hours interacts with other factors related to social capital to explain dropout intent. These findings provide novel insights into the dropout literature by refreshing thoughts on the role of teacher-student and peer relations in the dropout intentions of student employees. In addition to reviving the relevance of university social capital, which has received too little attention lately, they have also sparked a recent debate on whether or not combining work and university actually affects the intention to drop out.
Thermally tunable GeSi electro-absorption modulator with a wide effective operating wavelength range
Authors: Liu Yufei , Sun Jialiang , Li Xinyu , Wang Shuxiao , Yue Wencheng , Cai Yan , Yu Mingbin
Published: May 2023

We demonstrate a GeSi electro-absorption modulator with on-chip thermal tuning for the first time, to the best of our knowledge. Theoretical simulation proves that the device temperature can be tuned and the effective operating wavelength range can be broadened. When the heater power is 4.63 mW, the temperature of the waveguide increases by about 27 K and the theoretical operating wavelength range is broadened by 23.7 nm. The experimental results show that the optical transmission line shifted to the longer wavelength by 4.8 nm by every 1 mW heater power. The effective static operating wavelength range of the device is increased from 34.4 nm to 60.1 nm, which means it is broadened by 25.7 nm. The band edge shift coefficient of 0.76 nm/K is obtained by temperature simulation and linear fitting of the measured data. The device has a 3 dB EO bandwidth of 89 GHz at 3 V reverse bias, and the eye diagram measurement shows a data rate of 80 Gbit/s for non-return-to-zero on–off keying modulation and 100 Gbit/s for 4 pulse amplitude modulation in the 1526.8 nm to 1613.2 nm wavelength range as the heater power increases from 0 mW to 10.1 mW.
Triaxial accelerometer-measured physical activity and functional behaviours among people with High Grade Glioma: The BrainWear Study
Authors: Dadhania Seema , Pakzad-Shahabi Lillie , Mistry Sanjay , Williams Matt
Published: May 2023

Background

High-grade gliomas (HGG) account for 60–75% of all adult gliomas. The complexity of treatment, recovery and survivorship creates a need for novel monitoring approaches. Accurate assessment of physical function plays a vital role in clinical evaluation. Digital wearable tools could help us address unmet needs by offering unique advantages such as scale, cost and continuous real-world objective data. We present data from 42 patients enrolled into the BrainWear study.

Methods

An AX3 accelerometer was worn by patients from diagnosis or at recurrence. Age-, sex-matched UK Biobank control groups were chosen for comparison.

Results

80% of data were categorised as high-quality demonstrating acceptability. Remote, passive monitoring identifies moderate activity reduces both during a course of radiotherapy (69 to 16 minutes/day) and at the time of progressive disease assessed by MRI (72 to 52 minutes/day). Mean acceleration (mg) and time spent walking daily (h/day) correlated positively with the global health quality of life and physical functioning scores and inversely with the fatigue score. Healthy controls walked on average 2.91h/day compared to 1.32h/day for the HGG group on weekdays and 0.91h/day on the weekend. The HGG cohort slept for longer on weekends (11.6h/day) than weekdays (11.2h/day) compared to healthy controls (8.9h/day).

Conclusion

Wrist-worn accelerometers are acceptable and longitudinal studies feasible. HGG patients receiving a course of radiotherapy reduce their moderate activity by 4-fold and are at least half as active as healthy controls at baseline. Remote monitoring can provide a more informed and objective understanding of patient activity levels to help optimise health related quality of life (HRQoL) among a patient cohort with an extremely limited lifespan.
A comparative analysis of APGAR score and the gold standard in the diagnosis of birth asphyxia at a tertiary health facility in Kenya
Authors: Njie Albertine Enjema , Nyandiko Winstone Mokaya , Ahoya Phinehas Ademi , Moutchia Jude Suh
Published: May 2023

Background

Birth asphyxia is a consistent key contributor to neonatal morbidity and mortality, notably in sub-Saharan Africa. The APGAR score, though a globally used diagnostic tool for birth asphyxia, remains largely understudied especially in resource-poor settings.

Objective

This study determined how effectively the APGAR score is used to diagnose birth asphyxia in comparison to the gold standard (umbilical cord blood pH <7 with neurologic involvement) at Moi Teaching and Referral Hospital (MTRH), and identified healthcare provider factors that affect ineffective use of the score.

Methods

Using a quantitative cross-sectional hospital-based design, term babies born in MTRH who weighed ≥2500g were randomly and systematically sampled; and healthcare providers who assign APGAR scores were enrolled via a census. Umbilical cord blood was drawn at birth and at 5minutes for pH analysis. APGAR scores assigned by healthcare providers were recorded. Effective use of the APGAR score was determined by sensitivity, specificity, positive and negative predictive values. At a significance level of 0.05, multiple logistic regression analysis identified the independent provider-associated factors affecting ineffective use of the APGAR score.

Results

We enrolled 102 babies, and 50 (49%) were females. Among the 64 healthcare providers recruited, 40 (63%) were female and the median age was 34.5years [IQR: 31.0, 37.0]. Assigned APGAR scores had a sensitivity of 71% and specificity of 89%, with positive and negative predictive values of 62% and 92% respectively. Healthcare provider factors associated with ineffective APGAR score use included: instrumental delivery (OR: 8.83 [95% CI: 0.79, 199]), lack of access to APGAR scoring charts (OR: 56.0 [95% CI: 12.9, 322.3]), and neonatal resuscitation (OR: 23.83 [95% CI: 6.72, 101.99]).

Conclusion

Assigned APGAR scores had low sensitivity and positive predictive values. Healthcare provider factors independently associated with ineffective APGAR scoring include; instrumental delivery, lack of access to APGAR scoring charts, and neonatal resuscitation.
The effects of an integrated exercise and cardiovascular health education programme on community-dwelling older adults at risk of atherosclerotic cardiovascular diseases: A study protocol for a randomised controlled trial
Authors: Lo Flora M. W. , Wong Eliza M. L. , Ho Ka Yan
Published: May 2023

Background

Although older adults are at an increased risk of atherosclerotic cardiovascular disease (ASCVD), the effect of an integrated exercise and cardiovascular health education programme based on self-efficacy theory has not been well investigated among older adults. This study aims at examining the effect of this programme on community-dwelling older adults at risk of ASCVD concerning physical activity level, exercise self-efficacy and ASCVD risk profile.

Methods

A parallel two-arm randomised controlled trial with pretest-posttest design will be performed among 190 Chinese community-dwelling adults aged 60 or above in elderly community centres of the Guangdong-Hong Kong-Macao Greater Bay Area. Eligible participants will be randomised by computerised generation. Experimental group will receive a 12-week integrated exercise and cardiovascular health education programme, which comprises a one-hour group-based health education talk conducted at Week 1, a booklet, a lecture video, a tailor-made exercise video, and a booster intervention by text messaging starting from Week 1 to Week 12. Control group will receive placebo intervention including a talk on basic health issues, a lecture video and corresponding leaflet. The outcomes will be investigated through self-report questionnaires and physiological evaluations at baseline, Week 12, Week 24, and Week 36. Physical activity level, exercise self-efficacy and ASCVD risk profile will be assessed, with physical activity level at Week 24 considered the primary outcome. The main intervention effect (group differences on continuous outcome variables) will be examined via Generalized Estimating Equations with identity link.

Discussion

This study findings will provide clues to the effect of the integrated exercise and cardiovascular health education programme, which is theoretically underpinned with self-efficacy theory, in older adults at risk of ASCVD. It will also enhance the quality of community health education by providing insight into the effective teaching strategies targeting older adults.

Trial registration

This study has been registered on ChinicalTrial.gov (Trial ID:NCT05434273).
Advanced prodrug approaches for neurodegenerative diseases
Authors: Raju Rashu , Nayak Anjali , Das Paramita , Gajmer Anmol , A Ramya , R Tejaswini
Published: May 2023

The prodrug technique is still one of the most effective ways to increase hydrophilic substances' medicinal, pharmacodynamic and pharmacokinetic properties. Prodrugs produced in current history have shown good pharmacokinetic characteristics, allowing for a more consistent release and fewer changes in plasma levels. Developing new prodrugs having a desirable ADME (Absorption Distribution Metabolism and Elimination) properties and that still can cross the Blood brain barrier (BBB) and pharmacologically active an appealing task for medicinal chemists. The loss of brain neuron activity characterizes neurodegenerative illnesses, resulting in progressive Gradual cognitive impairment (GCI). Some of the common neurodegenerative diseases are PD (Parkinson's disease), AD (Alzheimer's disease), MS (Multiple sclerosis), ALS (amyotrophic lateral sclerosis) & HD (Huntington's disease) are examples of neurodegenerative illnesses with a variety of etiologies and morphological and pathophysiological aspects. The current review is concerned with current advances in prodrug approaches for the treatment and prevention of the most prevalent neurological illnesses, as well as their absorption, selective CNS targeting and chemical and enzymatic stability.
Scheduled tribes (ST) students: Challenge & development
Authors: Sarkar Pran Krishna
Published: May 2023

High School education for ST students is seen as one of the most emerging policy issues of contemporary India. Teachers engaged in teaching of ST student’s face unique set of challenges, which are emerged primarily from the unique cultural patterns of Bedia and Santal community. This study was conducted in the native area of Nadia district of west Bengal. Interview of the teachers was conducted in order to get valuable data for understanding the research problem. Data was subjected to rigorous of content analysis to unveil the major themes and patterns in the interview data. The study identified that the issue with teaching ST students lies in their inability to adapt in normal school conditions. The study also reveals that there are large gaps between school culture and family culture of children, creating a situation of cultural mismatch, resulting into creating discipline problems, management problems and poor responsiveness of Bedia and Santal students towards academic activities.
Phytochemistry and biological activities of latex from Schubertia grandiflora Mart. (Apocynaceae)
Authors: Silva Márcia Divina Vidal , Menezes Filho Antonio Carlos Pereira de , Sharma Porshia , Cruz Rafael Martins da , Souza Amanda de Oliveira , Taques Aparecida Sofia , Silva Adrielle Pereira da , Castro Carlos Frederico de Souza , Ventura Matheus Vinicius Abadia
Published: May 2023

Schubertia grandiflora is a plant species that produces latex from roots to flowers. This study aimed to evaluate the latex of S. grandiflora on qualitative phytochemical analysis and effects of quantitative biological activities. Latex was collected from logs. Phytochemical analysis of precipitation and colorimetry were carried out for several groups of phytogroups. Antifungal activity was performed on Sclerotinia sclerotiorum, Colletotrichum acutatum and C. gloeosporioides, cytotoxic activity on Artemia salina, antioxidant activity on DPPH free radical and determination of inhibition on acetylcholinesterase. The latex proved to be rich in phytochemical groups, inhibition capacity of S. sclerotiorum with 64% and for C. gloeosporioides of 30%, low rate of cytotoxicity with 25% in 1000 µg mL-1, reduction of DPPH free radical of 67% and AChE inhibition of 86%. Schubertia grandiflora latex proved to be a potential natural phytochemical agent for diverse biological activities through this study.
A Narrative Review of Financial Burden, Distress, and Toxicity of Inflammatory Bowel Diseases in the United States
Authors: Kahn-Boesel Olivia , Cautha Sandhya , Ufere Nneka N. , Ananthakrishnan Ashwin N. , Kochar Bharati
Published: May 2023

INTRODUCTION:

Inflammatory bowel diseases (IBD) affect >3 million Americans and are associated with tremendous economic burden. Direct patient-level financial impacts, financial distress, and financial toxicity are less well understood. We aimed to summarize the literature on patient-level financial burden, distress, and toxicity associated with IBD in the United States.

METHODS:

We conducted a literature search of US studies from 2002 to 2022 focused on direct/indirect costs, financial distress, and toxicity for patients with IBD. We abstracted study objectives, design, population characteristics, setting, and results.

RESULTS:

Of 2,586 abstracts screened, 18 articles were included. The studies comprised 638,664 patients with IBD from ages 9 to 93 years. Estimates for direct annual costs incurred by patients ranged from $7,824 to $41,829. Outpatient costs ranged from 19% to 45% of direct costs, inpatient costs ranged from 27% to 36%, and pharmacy costs ranged from 7% to 51% of costs. Crohn’s disease was associated with higher costs than ulcerative colitis. Estimates for indirect costs varied widely; presenteeism accounted for most indirect costs. Severe and active disease was associated with greater direct and indirect costs. Financial distress was highly prevalent; associated factors included lower education level, lower household income, public insurance, comorbid illnesses, severity of IBD, and food insecurity. Higher degrees of financial distress were associated with greater delays in medical care, cost-related medication nonadherence, and lower health-related quality of life.

DISCUSSION:

Financial distress is prevalent among patients with IBD; financial toxicity is not well characterized. Definitions and measures varied widely. Better quantification of patient-level costs and associated impacts is needed to determine avenues for intervention.
Effect of metformin on transcriptome and adipokinome of adipocytes of local fat deposts of patients with ischemic heart disease
Authors: Dyleva Yu. A. , Gruzdeva O. V. , Belik E. V. , Borodkina D. A. , Sinitskiy M. Yu. , Ivanov S. V. , Barbarash O. L.
Published: May 2023

BACKGROUND: The information available to date on the effect of metformin on the transcriptome and secretory capacity of adipocytes in human adipose tissue (AT) is scarce and contradictory. The study analyzed whether metformin in vitro modulates gene expression and secretion of adiponectin and leptin in the AT of subcutaneous (SAT), epicardial (EAT) and perivascular (PVAT) localization of patients with ischemic artery disease (IHD).

AIM: To assess the effect of metformin at various concentrations (1 and 10 mmol / L) on the level of expression of adiponectin and leptin genes and their content in adipocytes of subcutaneous, epicardial and perivascular AT of patients with IHD.

MATERIALS AND METHODS: The study included 134 patients with IHD and indications for direct myocardial revascularization by coronary artery bypass grafting (CABG). During the operation, biopsies of SAT, EAT and PVAT were obtained for 3–5 gram, which served as a source of adipocytes. Isolated adipocytes were cultured for 24 hours with and without metformin (1 and 10 mmol / L). After a day of incubation, the expression of the ADIPOQ and LEP genes and the level of secretion of adiponectin and leptin in the culture medium of adipocytes were determined. Statistical processing was performed using the GraphPad Prism 6 software package (GraphPad Software, La Jolla, CA, USA) and Statistica software, 6.1 (Dell Software, Inc., Round Rock, TX, USA).

RESULTS: The adipocytes of the EAT and PVAT of patients with IHD were characterized by an imbalance in the adipokine system, manifested by a low level of ADIPOQ expression and a high LEP expression in comparison with adipocytes of the SAT. Metformin increased the level of ADIPOQ expression and its secretion by adipocytes regardless of their location, while a low concentration (1 mmol / L) in adipocytes of EAT had a stronger effect compared to 10 mmol / L. Metformin had a multidirectional effect on the level of leptin in adipocytes, which depended on their localization: both in low (1 mmol / L) and high concentrations (10 mmol / L), the drug reduced the level of LEP expression and protein secretion in the culture medium of adipocytes of the SAT. EAT had no significant effect on adipocytes. In PVAT, metformin increased the expression and secretion of leptin regardless of concentration.

CONCLUSION: Metformin has a direct effect on adipocytes in SAT, EAT, and PVAT and is able to modulate their activity, which is a promising strategy for maintaining the balance of adipokines in AT, especially epicardial and perivascular localization.
Investigando a utilização de um dicionário pedagógico no 2º ano do Ensino Fundamental
Authors: Baffi-Bonvino Melissa Alves
Published: May 2023

Este trabalho se origina de um estudo de caso sobre o aproveitamento de um dicionário pedagógico monolíngue, o Primeiro Dicionário Escolar - Língua Portuguesa, de Nelly Novaes Coelho, em uma classe de 2º ano do Ensino Fundamental, correspondente à primeira etapa da educação básica no Brasil. Diante da importância das pesquisas sobre o uso de dicionários para o desenvolvimento da Lexicografia Pedagógica, o estudo enfoca a utilização da obra lexicográfica por meio do relato real e das percepções de uma professora, a fim de analisar o modo como essas mesmas percepções influenciam o processo de exploração multimodal dos recursos verbais e não verbais na introdução à informação lexicográfica. A investigação está inserida em uma abordagem qualitativa descritiva sobre a situação de uso do dicionário e tem como principal instrumento de geração de dados um questionário respondido pela professora. Do estudo, conclui-se que a interação com o dicionário pedagógico foi realizada de maneira adequada ao projeto de ensino, com o aproveitamento positivo da obra lexicográfica.
EDUCAÇÃO BASEADA EM COMPETÊNCIA: Desenvolvimento de atividade experimental de ensino para o curso de Engenharia de Produção
Authors: Lauermann Carlos Henrique , Lopes Antônio , Otero Henrique , Dutra Camila , Ten Caten Carla
Published: May 2023

O ensino e aprendizagem da engenharia no Brasil passaram por transformações nos últimos anos em função da aceleração tecnológica. O mercado de trabalho de engenharia passou a exigir um profissional mais crítico e capaz de resolver problemas. Neste novo contexto, a metodologia de ensino baseado em competências (CBE) surge como alternativa dos métodos tradicionais de aprendizagem. O presente trabalho visa apresentar uma proposta de atividade de ensino experimental que utiliza a aprendizagem ativa na disciplina de Engenharia de Qualidade do curso de Engenharia de Produção na Universidade Federal do Rio Grande do Sul (UFRGS). O Laboratório de Inovação e Fabricação Digital (LIFEELAB) foi escolhido como cenário da atividade de ensino. Alunos realizam um projeto experimento utilizando a tecnologia de corte a laser para avaliar a influência de parâmetros de corte como a potência de corte e a velocidade de deslocamento. São avaliadas quatro competências nesta atividade. É realizada a avaliação da percepção dos alunos utilizando a escala Likert. De modo geral, os alunos concordam que as competências são desenvolvidas através da prática, apresentado pontuação de 4,53, indicando um resultado satisfatório. As competências melhor avaliadas são as competências técnicas, pois os alunos experimentam gerir um processo e realizar cálculos que visam a otimização. Por outro lado, as competências transversais são avaliadas com notas mais baixas, indicando possíveis melhorias
PROCESSO ON-LINE DE ACOMPANHAMENTO E AVALIAÇÃO DE UM PROJETO FINAL DE CURSO DE GRADUAÇÃO COM PARTICIPAÇÃO DE ALUNOS DA PÓS-GRADUAÇÃO
Authors: Leal Fabiano
Published: May 2023

Este relato de experiência apresenta um modelo de processo on-line de acompanhamento e avaliação para um Projeto Final de Curso de graduação, aplicado dentro do curso de graduação em Engenharia de Produção da Universidade Federal de Itajubá (UNIFEI), campus Itajubá, Minas Gerais. Além da descrição textual deste processo, ele também será apresentado por meio da notação BPMN (Business Process Model and Notation). Este relato apresenta ainda as melhorias implementadas neste modelo ao longo dos últimos anos e as que estão planejadas. Destacam-se neste modelo o uso de planilha on-line para gerenciamento do fluxo de informações e gestão do fluxo de arquivos digitais entre alunos e avaliadores, os diversos pontos de avaliação ao longo do projeto e a participação de alunos da pós-graduação em diferentes etapas, gerando não somente uma integração com a pós-graduação, mas também com o Núcleo Docente Estruturante do curso. Este relato finaliza com a descrição de resultados obtidos com este modelo, tanto do ponto de vista do aluno avaliado quanto da coordenação. As lições aprendidas são descritas ao final, destacando a ação necessária do coordenador, uma recomendação de configuração de compartilhamento da planilha on-line para evitar perdas de informação e os cuidados necessários na integração com a pós-graduação.
DISCIPLINA DE INTRODUÇÃO À ENGENHARIA DE PRODUÇÃO NA FURG: UMA EXPERIÊNCIA QUE UNE DIGITAL E FÍSICO
Authors: Corrêa Ricardo , Medeiros Jorge Luis , Peres Fernanda , Ozório Bianca , Gomes Leonardo , Bondarczuk Beniamin , Baierle Ismael
Published: May 2023

A disciplina de Introdução à Engenharia de Produção é o primeiro contato do aluno com uma disciplina específica do curso que escolheu. Associado a esse fato, os alunos da Universidade Federal do Rio Grande (FURG) usualmente possuem pouca ou nenhuma experiência prática e conhecimento das áreas do curso de Engenharia de Produção (EP). A fim de melhor acolher o aluno recém ingressante e preencher suas lacunas, foi proposta uma experiência que combinou entrevistas com especialistas nas 10 áreas do curso de EP e a Aprendizagem Baseada em Projetos (ABP). Essa combinação é resultado da evolução da disciplina desde 2019, que resultou em vídeos que registraram as entrevistas sobre as 10 áreas e na construção de 13 catapultas através da ABP. Os vídeos já tiveram mais de 10 mil visualizações e a disciplina contribuiu para motivar e aumentar o cabedal de conhecimento dos alunos quanto ao curso que escolheram.
DESENVOLVIMENTO DE ARTIGOS CIENTÍFICOS COMO ESTRATÉGIA DE ENSINO-APRENDIZAGEMAVALIAÇÃO EM ENGENHARIA ECONÔMICA
Authors: Lima José Donizetti , Colombo Janecler , Petri Jaqueline , Oliveira Gilson
Published: May 2023

O objetivo de escrever este texto foi apresentar e analisar uma proposta de ensino-aprendizagem-avaliação para a disciplina de Engenharia Econômica (EE) pautada na elaboração de artigos científicos. A perspectiva adotada vai na direção de metodologias de ensino e aprendizagem ativas e participativas, uma vez que o estudante se torna protagonista de sua aprendizagem, sempre com a intervenção orientada do docente. Essa proposta foi aperfeiçoada durante o período de aulas no estilo remoto, transformando o momento de crise na educação superior em uma oportunidade de aprendizagem inovadora. Essa abordagem educacional na condução da disciplina de EE apresentou-se como uma alternativa eficiente para auxiliar na inovação da prática docente, contribuindo para: (i) conectar teoria e prática, com a resolução de problemas reais na área de conhecimento do acadêmico; (ii) integrar ensino-pesquisaextensão; (iii) facilitar a pesquisa interdisciplinar; (iv) melhorar a autonomia do discente; e (v) auxiliar no desenvolvimento de competências exigidas pelo mercado: conhecimentos, habilidades e atitudes.
Ohlédnutí za Jeanem Baechlerem
Authors: Německý Marek
Published: May 2023

Obituary
Martin Pelc: Na football!: Fotbalové diváctví a fanouškovská kultura v českých zemích do roku 1939. Praha: NLN 2022, 384 str.
Authors: Urban Adam
Published: May 2023

Book review on Martin Pelc: Na football!: Fotbalové diváctví a fanouškovská kultura v českých zemích do roku 1939. Praha: NLN 2022, 384 str.
Martin Dolejský: České Grado. Čelákovice: Městské muzeum v Čelákovicích 2022, 97 str.
Authors: Štemberk Jan
Published: May 2023

Book review on Martin Dolejský: České Grado. Čelákovice: Městské muzeum v Čelákovicích 2022, 97 str.
Prof. PhDr. Drahomír Jančík, CSc., pětasedmdesátiletý
Authors: Jakubec Ivan
Published: May 2023

Anniversary: Prof. PhDr. Drahomír Jančík, CSc., pětasedmdesátiletý
Miloslav Petrusek ironický a subverzivní
Authors: Paulíček Miroslav
Published: May 2023

News: Miloslav Petrusek ironický a subverzivní
Od polyarchií k autokraciím: Studium režimních transformací a jeho reflexe
Authors: Strmiska Maxmilián , Bílek Jaroslav
Published: May 2023

This essay addresses several pertinent issues of interpretations of processes of autocratization pertaining to two different historical contexts. The authors seek to identify major arguments concerning theoretical backgrounds in the current agendas of research into the transitions from the polyarchic republican city-states to the authoritarian regimes of personal power in the Renaissance Italy and into the contemporary processes of autocratic reversals. The authors strive to show that it is useful to pay thorough attention to varying theoretical challenges characterizing agendas of research into historically diverse regime transitions. In such a way, it is possible to expose and assess limits and directionality of prevailing research programs. This seems important in order to gain new incentives for an advancement of thinking about both contemporary and historical processes of autocratization and to enhance a promising cross-fertilization of the study of regime changes conducted by political science, historical sociology and historiography.
Svět automobilu jako součást divadelního repertoáru od konce monarchie do druhé světové války
Authors: Jakubec Ivan
Published: May 2023

The paper focuses on a hitherto unexplored area of research into the modern means of transport – the automobile and automotive issues in the field of theatre. The author has approached this area of problems from a developmental, historical and cultural-historical point of view. The basis consists of selected (surviving) theatre plays (including signs and posters) that appeared on stage in various forms and shapes from the end of the monarchy to the Second World War. The paper is based on a study of the library collections of the IDU (Institute of Theatre Arts) Library, the National Library and the database of the “Czech Amateur Theatre”.
Max Weber Gesamtausgabe, Bd. I/7 and I/12. Tübingen: Mohr Siebeck 2018
Authors: Árnason Jóhann Páll
Published: May 2023

Review article
The mechanism for the positive effect of foreign language peace of mind in the Chinese EFL context: a moderated mediation model based on learners’ individual resources
Authors: Zhou Li , Lochtman Katja , Xi Yiheng
Published: May 2023

Foreign language peace of mind (FLPOM) is conceptualized as a Chinese culture-specific low-arousal positive emotional state of inner peace and harmony. It is used to describe learners’ psychological well-being in the Chinese English as a foreign language (EFL) context. This study examines the intermediate mechanism for the positive effect of FLPOM on language achievement by testing learners’ cognitive engagement as a mediator on the relationship between FLPOM and language achievement and competitive psychological climate as a moderator of the mediation effect. Foreign language enjoyment (FLE), a comparatively high-arousal positive emotion, is also tested in the same model for comparison purposes. Results showed that cognitive engagement mediated the relationship between both FLPOM and FLE and language achievement and that competitive psychological climate negatively moderated (i.e., weakened) the mediation effect of cognitive engagement on FLE and achievement, but did not moderate the mediation effect of cognitive engagement on FLPOM and achievement. The findings point to the role of FLPOM in gaining learners’ individual resources (e.g., cognitive engagement) and, more importantly, the distinctive role of the low-arousal emotion of FLPOM in lowering resource loss and maintaining learner engagement in high resource loss (e.g., high competitiveness, high stress) circumstances.
Comparison of interferon-gamma production between TB1 and TB2 tubes of QuantiFERON-TB Gold Plus: a meta-analysis
Authors: Darmawan Guntur , Liman Lie Monica Sherine , Hamijoyo Laniyati , Atik Nur , Alisjahbana Bachti , Sahiratmadja Edhyana
Published: May 2023

Objectives

CD8 T-cells play an important role in interferon-gamma (IFN-γ) production as a host defense against tuberculosis (TB) infection. Therefore, QuantiFERON-TB Gold Plus (QFT-Plus) was developed by adding a TB2 tube beside the TB1 tube. This study aimed to compare and analyze the difference in IFN-γ production between the two tubes in general and specific populations.

Content

PubMed, Web of Science, and EBSCO were searched for studies reporting IFN-γ production levels in the TB1 and TB2 tubes. Statistical analysis was performed using RevMan 5.3.

A total of 17 studies met the inclusion criteria. The IFN-γ production in the TB2 tube was statistically higher than that in the TB1 tube (mean difference (MD)=0.02, 95 % confidence interval (95 % CI): 0.01–0.03). Further subgroup analysis in specific populations revealed that the MD of IFN-γ production between the TB2 and TB1 tubes was significantly higher in active TB subjects than in latent TB infection (LTBI) subjects (MD=1.13, 95 % CI: 0.49–1.77, and MD=0.30, 95 % CI: 0.00–0.60, respectively). A similar finding was found in immune-mediated inflammatory disease subjects, but not statistically significant. Interestingly, IFN-γ production capacity was lower in active TB subjects than in LTBI subjects in each of the TB1 and TB2 tubes.

Outlook

This study is the first to systematically compare IFN-γ production between the TB1 and TB2 tubes. The IFN-γ production was higher in the TB2 tube than in the TB1 tube, representing the host’s CD8 T-cell response magnitude to TB infection.
Assessment of cytotoxic and apoptotic activities of the Cassia angustifolia aqueous extract against SW480 colon cancer
Authors: Momenah Maha Abdullah , Alqahtani Alaa Ali , AL Qassim Fatima Abdullah , Alotaibi Amani Mohammed , Albasher Gadah , Al-Qahtani Wedad Saeed
Published: May 2023

The current natural extract modalities for colorectal cancer are limited. This research seeks to assess the process of extracting the plant’s bioactive constituents from Cassia angustifolia and to show the anticancer role played by the plant’s aqueous extract at 0°C by identifying the genes that alter in expression after the Cassia angustifolia treatment in colon cancer cells. The bioactive components of Cassia angustifolia extract were revealed using gas chromatography-mass spectrometry analysis. The colon carcinoma cell lines (SW480) were treated with Cassia angustifolia macrophages at concentrations of 50, 150, and 200 µg/mL for 48 h. Apoptosis was examined by fluorescence-activated cell sorting analysis of Cassia angustifolia-treated and -untreated cells. Microarray analysis was performed by using human microarray chips (HG-U95A) for untreated and treated SW480 cells. Microarray data were confirmed by the reverse transcription polymerase chain reaction. The findings showed that the Cassia angustifolia aqueous extract at 0°C/24 h contained the entire absolute phenolic content of 28.43 mg/g and the entire absolute flavonoid content of 9.16 mg/g. Cassia angustifolia enhanced the hindrance of cell development and apoptosis and decreased glucose uptake. Western blot analysis showed induction in the expression of cleaved caspases 3 and 9 in SW480 cells. Microarray data identified 11 genes and 7 expressed sequence tags (ESTs) markedly altered in treated vs non-treated SW480 cells. Several of these genes have been embroiled in multiple malignancies. In conclusion, the current study provides remarkable new data for Cassia angustifolia extracted at 0°C/24 h. We discovered 7 ESTs and 11 genes that are significantly altered in the progression of SW480 cells treated with Cassia angustifolia therapy versus no treatment, with anticancer and apoptosis inducer effects.
Impact of using a predictive neural network of multi-term zenith angle function on energy management of solar-harvesting sensor nodes
Authors: Al-Omary Murad , Aljarrah Rafat , Albatayneh Aiman , Alshabi Dua’a , Alzaareer Khaled
Published: May 2023

Using the Neural Networks to predict solar harvestable energy would contribute to prolonging the duration of the effective operation and thus less consumption in solar-harvesting sensor nodes. The NNs with higher prediction accuracy have the longest effective operation. Till now, the NNs that use the zenith angle function as input have been utilized with only two terms. This paper shows the advantages of using a multi-term zenith angle function on the energy management in the nodes. To this end, this paper considers two, three, and four terms for the function of the zenith angle. The results showed that the case of four terms has the lowest prediction mistakes on average (0.83%) compared to (2.13% and 1.75%) for the cases of two and three terms, respectively. This is followed by a reduction in energy consumption in favor of four terms case. For one month simulation period with hourly prediction, the sensor node worked at the higher consumption mode (M2) in the case of four terms 4 hours less than three terms and 7 hours less than two terms case. Thus, increasing the number of terms in the zenith angle function leads to higher accuracy and less energy consumption.
Islanding detection and power quality disturbance classification in multi DG based microgrid using down sampling empirical mode decomposition and multilayer neural network
Authors: Choudhury Anasuya Roy , Nayak Pravati , Mallick Ranjan Kumar , Agrawal Ramachandra , Mishra Sairam , Panda Gayadhar
Published: May 2023

Power Quality, Equipment and Personnel safety of any distributed generation (DG) system connected to utility Grid merely depends on accurate detection of Islanding and non-islanding Power quality disturbances. The main objective of the proposed research is to detect islanding events with very narrow non-detection zone (NDZ) and classification of power quality disturbances with higher accuracy using signal processing and intelligent method together. A noise robust down sampling empirical mode decomposition (DEMD) is used to extract signature of islanding and power quality (PQ) disturbance features from the collected voltage signals and multilayer perceptron neural network (MLNN) is proposed to classify islanding and non-islanding (PQ) events. The performance of the proposed (DEMD-MLNN) technique is verified with IEEE-9 bus distributed generation system dominated by solar &wind energy penetration. The simulation work is carried out in MATLAB/Simulink platform. The efficacy of the proposed DEMD-MLNN is verified by large number of numerical experimentations with and without noise and comparing with existing competitive well-known techniques.
Drying Kinetics of American Ginseng Slices in Thin-layer Air Impingement Dryer
Authors: Wang Dong , Dai Jian-Wu , Ju Hao-Yu , Xie Long , Xiao Hong-Wei , Liu Yan-Hong , Gao Zhen-Jiang
Published: May 2023

Thin-layer air impingement drying kinetics of American ginseng slices were investigated under different drying temperatures (35, 40, 45, 50, 55, 60, and 65°C), air velocities (3, 6, 9, and 12 m/s), and sample thicknesses (1, 2, 3, and 4 mm). Results indicated that the drying time is more significantly affected by drying temperature followed by sample thickness and air velocity. Drying rate curves illustrated that the whole drying process happened in the falling rate period. Additionally, from initial drying to the moisture content of about 0.5 kg/kg, the drying rate increased with the increase of drying temperature and air velocity or decreased with the increase of sample thickness. The moisture effective diffusivity (D
eff) was determined both neglecting shrinkage and considering shrinkage. The drying activation energy of American ginseng slices was 46.64 kJ/mol determined by Arrhenius relationship. The moisture effective diffusivity and drying activation energy of American ginseng slices were compared to other biomaterials and related issues were also discussed. The current work is useful for designing air impingement drying system, evaluating and saving energy consumption of American ginseng slices.
Hybrid WDM-PDM visible light communication system incorporating compressed spectrum return to zero advance modulation format
Authors: Turke Mandeep Singh , Lovkesh
Published: May 2023

Hybrid wavelength division multiplexing (WDM) and polarization division multiplexing (PDM) technology is a promising candidate for high capacity and extended reach in visible light communication (VLC) systems. However, multilevel modulations and direct modulation are suffered from two predominant limitations in VLC such as high complexity and frequency chirping respectively. Therefore, in this work, a high-capacity VLC system is presented by employing a hybrid WDM-PDM and compressed spectrum return to zero (CSRZ) advanced modulation format. Moreover, direct modulation is replaced with external modulation employing Mach-Zehndar modulators and red/green/blue (RGB) laser diodes (LDs). A detailed comparison of non-return to zero (NRZ) and CSRZ is performed at varied VLC lengths in terms of bit error rate (BER) and Q factor. Results revealed that CSRZ is far better than NRZ and external modulation offered an edge over direct modulation. The maximum VLC distance achieved using CSRZ is 229 cm within acceptable BER limits (10−3) without forward error correction (FEC).
Trucking (un)limited – the impact of digital platforms on labour in production networks of logistics
Authors: Helwing Veronique , Verfürth Philip , Franz Martin
Published: May 2023

For many years, struggles over value capture have been taking place between different actors in the logistics sector, creating ever more pressure for workers in traditional activities of logistics. New actors, in the form of digital business-to-business (B2B) platforms, which are proliferating especially in the freight transport sector, are further challenging the already contested field. Based on the Global Production Networks (GPN) approach, this study addresses the question of how B2B platforms affect labour in production networks of logistics, and what labour agency practices are emerging in the face of advancing platformisation. The study draws on interviews with various actors operating in the road freight transport sector in Germany. The results show that digital B2B platforms, due to their intermediary function, have a direct impact on the inclusion and exclusion of actors involved in production networks of logistics, and induce not only a race to the bottom in terms of labour conditions, but also produce increasingly contingent geographies of logistics. This paper contributes to the literature on platforms by examining previously neglected B2B platforms and shedding light on the different ways that labour in global production networks can be affected by new agents, such as digital platforms.