bluuebunny/crossref_metadata_2025 huggingface dataset:
El aprendizaje de la expresión emocional en interacción con la familia como alternativa para la promoción de la salud mental: Conceptualización e intervención cognitiva y transdiagnóstica de tres casos
Authors: Tobón Mora Kelly Yuliana , Blair-Gómez Carolina
Published: June 2024

Este artículo es una propuesta para la promoción de la salud mental, enfocada en el aprendizaje de la expresión emocional en interacción con la familia. Se revisan tres casos de acompañamiento terapéutico en la ciudad de Medellín a jóvenes entre los 21 y 26 años, que presentan síntomas de ansiedad, depresión, dificultades en la regulación emocional, en el establecimiento de relaciones, y con antecedentes de relaciones familiares fracturadas y hostiles debido a dificultades en la educación emocional. Se presenta la conceptualización e intervención cognitiva y transdiagnóstica de los casos. Los resultados muestran que la intervención permitió generar mejorías en la gestión funcional de emociones, disminución en los patrones de pensamiento disfuncional y mejorías sintomáticas.
Employment Skills Revisited: A Qualitative Exploration of Multi-Stakeholder Perspective in China’s “3+1” Higher Education Context
Authors:   Universiti Kebangssan Malaysia/Baicheng Normal University, Wang Wanyu , Hussin Muhammad ,   Universiti Kebangssan Malaysia, Majid Mohamad Zuber Abd.
Published: June 2024

The issue of employment for university students is receiving significant attention in China, leading to educational reforms aimed at enhancing students’ employment skills and prospects. One such initiative is the “3+1” higher education programs, characterized by work-based learning. However, the effectiveness of this initiative falls short of expectations due to insufficient understanding of the up-to-date employment skills required by the industry. As such, this qualitative study explored stakeholders’ perceptions regarding the employment skills needed by students enrolled in “3+1” programs. Key challenges and strategies associated with developing students ‘ employment skills were identified through interviews with students, teachers, curriculum planners, industry leaders, and human resource professionals. Findings revealed a consensus among stakeholders on the importance of developing a holistic skill set, acquiring practical experience, increasing adaptability and resilience, embracing lifelong learning, and improving communication skills. Challenges included mismatches between academic learning and industry demands, limited industry exposure, soft skill deficiency, inadequate assessment, insufficient university-industry cooperation, and students’ low motivation, for which corresponding strategies were proposed. This study provides valuable insights into enhancing the employability of “3+1” graduates, emphasizing the importance of comprehensive education aligned with industry needs.
The Rhetorical Uneasiness: A Study of Rebecca Whittington’s Translation of Jibanananda Das’s Malloban
Authors:   Department of Humanities and Social Sciences, Indian Institute of Engineering Science and Technology, Shibpur, Bhattacharyya Sampriti , Ghosh Sarbadhikary Mallika
Published: June 2024

This paper aims to explore the translation of socio-cultural and rhetorical nuances of language between Bangla and English with a case of the translation of Jibanananda Das’s 1973 novel Malloban by Rebecca Whittington in 2022. The act of translating such a rich and culturally nuanced text poses substantial challenges, as it involves the delicate balance of preserving the essence of the source text while making it accessible to a new linguistic and cultural context. In the process, the translator, whose native language is American English, is led to straddle domestication and exoticism, thus creating linguistic, semiotic, and syntactic variations in her rendition of the source language text. This paper attempts to assess the fidelity of the translation to the original work while scrutinizing the translator’s choices in capturing the intricate wordplay, colloquial expressions, metaphors, and narrative subtleties that are hallmarks of Jibanananda Das’s writing. This paper also examines the instances where the translation may inadvertently alter or dilute the original text’s impact and the implications of such alterations for readers of the translated work. Furthermore, this study delves into the emotional and cognitive dimensions of bilingual reading.
Navigating Multiple Burdens among Women in Government Service
Authors:   Instructor III, School of Healthcare Education, Mountain Province State Polytechnic College, Philippines., Chagyowen Cherry Ann B.
Published: June 2024

This study investigates the lived experiences of government-employed mothers in Sabangan, Mountain Province, Philippines, who juggle work, family, and community roles without domestic help. Employing descriptive phenomenology and thematic analysis, the research examines the effects of these multiple burdens on nine participants from various government institutions. Findings highlight both positive outcomes, like happiness and fulfillment, and negative impacts, such as exhaustion and stress. The study reveals strategies these women use to mitigate adverse effects and suggests policy changes for better government support. Recommendations include extended parental leave, more holidays, reduced work hours, and accessible childcare. The study underscores the need for shared familial responsibilities and legislative backing to aid working mothers in managing their multifaceted roles.
Book Review: Queersapien by Sharif D. Rangnekar
Authors:   CHRIST (Deemed to be University), Greater Noida, Uttar Pradesh, Gupta Aditi
Published: June 2024

Queersapien by Sharif D. Rangnekar is an intimate exploration into the multifaceted journey of a queer person, encapsulating the myriad instances of “coming out” that extend beyond the conventional narrative. In this poignant narrative, Rangnekar delves into the complexities of self-discovery, family disclosure, and the broader societal acceptance that marks the queer experience. The book skillfully navigates through the non-linear nature of the coming-out process, shedding light on the constant evaluation of risks and the perpetual quest for safe spaces in a world that does not always embrace queerness.
Subverting Anthropocentric Mythic Elements: Animal Representations in the Select Poems of Louise Glück and Mary Oliver
Authors:   Christ (deemed to be) University, Sunny Sandhra , Narayana Sharmila
Published: June 2024

The representation of animals in literature has long been dominated by anthropocentric perspectives that prioritize human experiences and values. Animals were relegated to metaphors and narrative accessories, neglecting their inherent rights and treating them primarily as reflections of human qualities. This paper examines the works of contemporary American poets Louise Glück and Mary Oliver, focusing on how their selected poems reconsider conventional anthropocentric patterns of animal representations in poetry. The analysis centers on the poets’ strategies to blur rigid boundaries between the human-animal divide by challenging conventional depictions where animals are frequently assigned peripheral roles. The study explores how these poems cultivate powerful connections with the natural world, fostering a sense of communion and interconnectedness with nature. Additionally, the research highlights the deliberate efforts by the poets to reconfigure hierarchies, challenge value dualisms, and question anthropocentric narratives that sanction oppression. Lastly, the paper contributes to the broader discourse on ecocritical thought, enriching discussions on literature and environmental activism.
Assessment of the presence of Vibrio cholera and detection of toxigenic Vibrio cholerae in river sources within the Vhembe District Municipality Limpopo province of South Africa
Authors: Kachienga Leonard , Prosperit Mafunise , Traore Afsatou Ndama , Potgieter Natasha
Published: June 2024

Most rivers in South Africa, particularly in rural areas, are contaminated and serve as a breeding ground for potential disease-causing microorganisms such as Vibrio cholera. Contaminated river sources could endanger the health of those communities that rely on them for domestic, agricultural, and recreational purposes. The aim of the study was to examine the presence of V. cholera and toxigenic V. cholera water samples from river sources collected in the Vhembe Municipal District during a three-month period. Physicochemical parameters, culture dependent and molecular techniques were used to identify V. cholerae in the samples. Majority of the physiochemical parameters were within the acceptable limit with exception of electrical conductivity readings in the Mvudi, Livuvhu, Dzindi, Nzhelele, Mutale, Shingwedzi, Tshinane and Nwedi rivers which were above the acceptable standard limit of 0–70 μS/cm. Most of the river samples tested positive for the presence of V. cholera, particularly on the downstream samples. Toxigenic V. cholerae was detected in four of the 12 samples that originally tested positive for V. cholera. The study revealed poor water quality and significant health concerns to consumers, emphasizing the importance of implementing river basin management measures to ensure the long-term sustainability of these rivers.
Incapacitas assumendi (kan. 1095 KPK) w świetle wyroku Roty Rzymskiej c. Da Costa Gomes z 17 lipca 2023 roku
Authors: Góralski Wojciech
Published: June 2024

Autor prezentuje wyrok Roty Rzymskiej dotyczący małżeństwa zawartego przez strony 23 sierpnia 1997 roku w jednym z kościołów parafialnych na terenie diecezji sosnowieckiej. Wspólnota małżeńska, nieobdarowana potomstwem, trwała ok. ośmiu lat, po czym mężczyzna wniósł (8 grudnia 2019 roku) do Sądu Diecezjalnego Sosnowieckiego pozew o stwierdzenie nieważności małżeństwa z tytułu niezdolności do podjęcia istotnych obowiązków małżeńskich (kan. 1095, n. 3 KPK) po stronie pozwanej. Po przeprowadzeniu instrukcji dowodowej i dokonaniu pozostałych czynności procesowych, w dniu 12 kwietnia 2022 roku Trybunał wydał wyrok negatywny, od którego powód wniósł apelację do Roty Rzymskiej, gdzie – po uzupełnieniu instrukcji dowodowej – turnus sędziowski c. Da Costa Gomes w dniu 27 lipca 2023 roku orzekł constare de nullitate.
¿Y si no podemos ver la bondad? Las “propiedades de persona” como alternativa para el perceptualismo moral
Authors: Villalobos Jacobo
Published: June 2024

Abrevando de la filosofía de la mente y de la ética filosófica, el perceptualismo moral argumenta que podemos tener experiencias perceptuales de propiedades morales, como “bueno” o “malo”, de la misma forma en que tenemos experiencias perceptuales de colores y formas. Es decir: el perceptualismo moral argumenta que podemos, literal, directa y simplemente ver la maldad, por ejemplo. A pesar de su amplio campo de estudio, estas perspectivas se han topado con objeciones formidables, como la objeción de las apariencias o las críticas de corte humeano, para las cuales no se han dado respuestas satisfactorias. Este texto se propone sostener que gran parte de los problemas a los que se enfrenta el perceptualismo moral son producto de una vaga caracterización de las propiedades morales a las que pretendidamente se aplica la percepción, y postular un tipo de propiedad alternativa que pueda ser, al mismo tiempo, moralmente relevante y aprehensible por la experiencia perceptual. Para ello, se van a postular las llamadas propiedades de persona como opción alternativa, y se fundamentará su valor ético y su pertinencia para el perceptualismo moral mediante la noción de superveniencia ética. Se destacará que esta ruta merece ser explorada en virtud de su potencial para superar las críticas usuales que se le oponen al perceptualismo moral.
Exploring Psychosocial Distress in Cancer Patients and Survivors: A Quick Overview
Authors: Shivappa Pooja , Bernhardt Grisilda Vidya , Gatti Priya , Radhakrishnan Vijay
Published: June 2024

:

Cancer remains one of the most prevalent diseases, with a high mortality rate, despite advancements in technology and science. Patients diagnosed
with cancer typically undergo a traumatic experience, enduring both mental anguish and physical exhaustion. Psychosocial distress is common
among cancer patients and can have a detrimental effect on their overall quality of life. Therefore, it is crucial for oncology healthcare
professionals to promptly evaluate psychosocial distress in cancer patients to improve their care and well-being. This review provides a concise
overview of the extensive literature on the epidemiology of various psychosocial disorders affecting cancer patients, including associated distress
and burdens, encountered challenges, pain symptoms, and potential evidence-based interventions or mandates in cancer care. Enhancing patientdoctor
communication and providing individualized care to the body and mind are necessary.
Europinidin Attenuates Methamphetamine-induced Learning and Memory Impairments and Hippocampal Alterations in Rodents: Based on Molecular Docking through a Mechanism of Neuromodulatory Cytokines/ Caspases-3/ CREB/BDNF Pathway
Authors: Sheikh Ryan A. , Afzal Muhammad , Al-Abbasi Fahad A. , Bukhari Hussam A. , Almalki Naif A. R. , Alqurashi May M. , Imam Faisal , Sayyed Nadeem , Kazmi Imran
Published: June 2024

Background:

Methamphetamine (MA) is well recognized as a psychostimulant
that can cause neurotoxicity and neurodegeneration, which is associated with cognitive
decline, has been confirmed experimentally.

Objective:

The research aimed to investigate the neuroprotective properties of europinidin
(Eu) in rodents affected by methamphetamine (MA)-induced cognitive impairments
and hippocampal alterations. This was achieved by inhibiting lipid peroxidation
and pro-inflammatory markers.

Methods:

Rats were exposed to cognitive impairment produced by MA. The Morris water
maze (MWM) is utilized for evaluating behavioral parameters. Tests were conducted
on malondialdehyde (MDA), catalase (CAT), interleukins-1β (IL-1β), reduced glutathione
(GSH), tumor necrosis factor-α (TNF-α), superoxide dismutase (SOD), and the
expression of neurotransmitters (Norepinephrine [NE], dopamine [DA], glutamate, and
gamma-aminobutyric acid [GABA]) as well as cAMP response element-binding protein
(CREB), IL-6, brain-derived neurotrophic factor (BDNF), and caspase 3 proteins. An investigation
was carried out using docking methodology to ascertain whether Eu interacts
with relevant molecular targets.

Results:

Significant decline in the transfer latency and there were significant changes in
the amount of SOD, GSH, CAT, and MDA and alterations in levels of IL-6, IL-1β,
CREB, TNF-α, BDNF, and Caspase 3 proteins expression, as well as considerably alterations
in level of neurotransmitters (NE, DA, Glutamate, and GABA) were observed in
the Eu-treated rats compared to the MA-induced rats. Eu had a favorable affinity towards
BDNF with docking scores of -9.486 kcal/mol.

Conclusion:

The experiment found that administering Eu to rats improved cognitive
abilities by changing antioxidant enzymes, reducing cytokines, and modifying neurotransmitter
levels, compared to rats in the control group treated with MA.
The Relationship between Dietary Habits and Gastroesophageal Reflux Disease: A Two-Sample Mendelian Randomization Study
Authors: Ou Haiya , Huang Hongshu , Ye Xiaopeng , Lin Haixiong , Wang Xiaotong
Published: June 2024

Purpose:

This study aimed to explore the potential causal relationship between
dietary habits and Gastroesophageal Reflux Disease (GERD).

Methods:

Using the inverse-variance weighted method, a two-sample Mendelian randomization
(MR) analysis was performed to investigate the causal relationship between
22 dietary habits and GERD. The stability and reliability of the results were assessed using
leave-one-out analysis, heterogeneity tests, and tests for horizontal pleiotropy based
on the effect measure odds ratio (OR) and 95% confidence interval (CI).

Results:

The results of the MR analysis indicated a positive association between alcohol
drinking (OR=1.472; 95% CI, 1.331 to 1.629; p<1.0×10-3) and salt added to food
(OR=1.270; 95% CI, 1.117 to 1.443; p<1.0×10-3) with the risk of GERD. Conversely,
bread intake (OR=0.613; 95% CI, 0.477 to 0.790; p<1.0×10-3), cereal intake (OR=0.613;
95% CI, 0.391 to 0.677; p<1.0×10-3), cheese intake (OR=0.709; 95% CI, 0.593 to 0.846;
p<1.0×10-3), dried fruit intake (OR=0.535; 95% CI, 0.404 to 0.709; p<1.0×10-3), fresh
fruit intake (OR=0.415; 95% CI, 0.278 to 0.619; p<1.0×10-3), and oily fish intake
(OR=0.746; 95% CI, 0.633 to 0.879; p<1.0×10-3) were negatively associated with the
risk of GERD. Sensitivity analysis showed no evidence of reverse causation, pleiotropy,
or heterogeneity.

Conclusion:

Alcohol and salt added to food raised GERD risk, while bread intake, cereal
intake, cheese intake, intake of certain dried fruits and certain fresh fruits, and oily
fish lowered it. Our study affirms the potential causal link between these diets and
GERD, offering insights into targeted prevention strategies.
Machine Learning-Driven Advancements in Liposomal Formulations for Targeted Drug Delivery: A Narrative Literature Review
Authors: Hoseini Benyamin , Jaafari Mahmoud Reza , Golabpour Amin , Rahmatinejad Zahra , Karimi Maryam , Eslami Saeid
Published: June 2024

Nanoliposomal formulations, utilizing lipid bilayers to encapsulate therapeutic agents,
hold promise for targeted drug delivery. Recent studies have explored the application of machine
learning (ML) techniques in this field. This study aims to elucidate the motivations behind integrating
ML into liposomal formulations, providing a nuanced understanding of its applications and
highlighting potential advantages. The review begins with an overview of liposomal formulations
and their role in targeted drug delivery. It then systematically progresses through current research
on ML in this area, discussing the principles guiding ML adaptation for liposomal preparation and
characterization. Additionally, the review proposes a conceptual model for effective ML incorporation.
The review explores popular ML techniques, including ensemble learning, decision trees, instance-
based learning, and neural networks. It discusses feature extraction and selection, emphasizing
the influence of dataset nature and ML method choice on technique relevance. The review underscores
the importance of supervised learning models for structured liposomal formulations,
where labeled data is essential. It acknowledges the merits of K-fold cross-validation but notes the
prevalent use of single train/test splits in liposomal formulation studies. This practice facilitates
the visualization of results through 3D plots for practical interpretation. While highlighting the
mean absolute error as a crucial metric, the review emphasizes consistency between predicted and
actual values. It clearly demonstrates ML techniques' effectiveness in optimizing critical formulation
parameters such as encapsulation efficiency, particle size, drug loading efficiency, polydispersity
index, and liposomal flux. In conclusion, the review navigates the nuances of various ML algorithms,
illustrating ML's role as a decision support system for liposomal formulation development.
It proposes a structured framework involving experimentation, physicochemical analysis,
and iterative ML model refinement through human-centered evaluation, guiding future studies.
Emphasizing meticulous experimentation, interdisciplinary collaboration, and continuous validation,
the review advocates seamless ML integration into liposomal drug delivery research for robust
advancements. Future endeavors are encouraged to uphold these principles.
HucMSCs-derived Exosomes Protect Against 6-hydroxydopamine-induced Parkinson’s Disease in Rats by Inhibiting Caspase-3 Expression and
Suppressing Apoptosis
Authors: Chen Hong-Xu , Xu Hong-Jun , Zhang Wang , Luo Zi-Yu , Zhang Zhong-Xia , Shi Hao-Han , Dong Yu-Chang , Xue Zhan-Jun , Ben Ying , An Sheng-Jun
Published: June 2024

Objective:

Parkinson’s disease (PD) is a progressive neurodegenerative disorder with
symptoms including tremor and bradykinesia, while traditional dopamine replacement therapy
and hypothalamic deep brain stimulation can temporarily relieve patients’ symptoms, they cannot
cure the disease. Hence, discovering new methods is crucial to designing more effective therapeutic
approaches to address the condition. In our previous study, we found that exosomes (Exos) derived
from human umbilical cord mesenchymal stem cells (hucMSCs) repaired a PD model by inducing
dopaminergic neuron autophagy and inhibiting microglia. However, it is not clear whether
its therapeutic effect is related to inhibiting apoptosis by inhibiting caspase-3 expression.

Methods:

Three intervention schemes were used concerning previous literature, and the dosage of
each scheme is the same, with different dosing intervals and treatment courses and to compare the
aspects of behavior, histomorphology, and biochemical indexes. To predict and determine target
gene enrichment, high-throughput sequencing and miRNA expression profiling of exosomes, GO
and KEGG analysis, and Western blot were used.

Results:

Exos labeled with PKH67 were found to reach the substantia nigra through the blood-
-brain barrier and existed in the liver and spleen. 6-hydroxydopamine (6-OHDA) induced PD rats
were treated with Exos every two days for one month, which alleviated the asymmetric rotation induced
by morphine, reduced the loss of dopaminergic neurons in the substantia nigra, and increased
dopamine levels in the striatum. The effect became more significant as the treatment time
was extended to two months. These results suggest that hucMSCs-Exos can inhibit the 6-OHDA-
induced neuron damage in PD rats, and its neuroprotective effects may be mediated by inhibiting
cell apoptosis. Through high-throughput sequencing of miRNA, potential targets for Exos to
inhibit apoptosis may be BAD, IKBKB, TRAF2, BCL2, and CYCS.

Conclusion:

The above results indicate that hucMSCs-Exos can inhibit 6-OHDA-induced damage
in PD rats, and its neuroprotective effect may be mediated by inhibiting cell apoptosis.
The Relationship between the Clinical Course of SARS-CoV-2 Infections and Expression of Bruton's Tyrosine Kinase
Authors: Rezaei Mitra , Babamahmoodi Abdolreza , Mirahmadi Alireza , Bineshfar Niloufar , Mahmoudi Shima , Ghadimi Somayeh , Valizadeh Melika , Malakouti Tannaz , Taheri Fatemeh Talebian , Mohammadpour Hadiseh , Azadani Farinaz Nasr , Ziai Seyed Ali , Poorhosseini Seyed Mohammad , Marjani Majid
Published: June 2024

Introduction:

Bruton’s Tyrosine Kinase (BTK), an important element for the pro-duction of several inflammatory cytokines, may play a role in the pathogenesis of COVID-19. This study aimed to assess BTK gene expression levels in COVID-19 cases based on disease severity and outcome.

Methods:

In this study, 33 hospitalized patients with COVID-19 were recruited and divided into two groups based on the severity of the disease: "mild to moderate" and "severe to critical". A blood sample was taken from each patient, peripheral blood mononuclear cells (PBMCs) were extracted, and BTK gene expression was measured. The level of BTK gene expression was compared based on the demographic data, laboratory results, and the severity and outcome of the disease.

Results:

Among 33 patients, 22 (66.7%) were male. Nearly half of the cases had at least one underlying disease. According to the severity of the disease, 12 patients were in the "mild to moderate" group, and 21 were in the "severe to critical" group; eight (24.2%) eventually died. Age, weight, and BMI had no significant relationship with BTK expression. BTK expression was significantly lower in "severe to critical" and ICU-admitted cases and in subjects with low O2 saturation. There was no significant difference in BTK expression between cured and dead patients (p=0.117).

Conclusion:

BTK gene expression in PBMCs had an inverse relationship with the severity of the disease of COVID-19. However, no correlation between BTK expression and disease outcome was observed.
Stylosin Exerts Cytotoxic and Apoptogenic Effects in Human Malignant
Glioblastoma Line and Hepatocellular Carcinoma Cells: The Role of
Reactive Oxygen Species
Authors: Alavi Mohaddeseh Sadat , Rashidi Roghayeh , Mobasheri Leila , Sheykhi Salmabad Nafiseh , Kazemi Seyedeh Safa , Mirzavi Farshad , Hosseini Azar
Published: June 2024

Objective::

Cancer is one of the major public health challenges globally and the second
cause of death in developed countries. Studies have shown that natural products can be effective
in treating cancer. The present study was conducted on the cytotoxicity and apoptogenic effects
of stylosin on the HepG2 and U87 cell lines.

Methods and Materials::

First, the cytotoxicity effect of stylosin was investigated using the MTT
method. Also, the production of reactive oxygen species was measured. The amount of cell
apoptosis was determined by the Sub G1 Peak method. Finally, to investigate the cellular and
molecular mechanisms involved in stylosin toxicity, the expression of P53, BAX, Bcl-2, Caspase
3, Caspase 9, and p53 genes were evaluated by the RT-PCR method.

Results::

Stylosin causes cytotoxicity in HepG2 and U87 cells in a time and concentrationdependent
pattern. It also significantly increases ROS production and stimulates apoptosis. It
induced a substantial enhancement in the expression of BAX, caspase3, and Caspase9 genes in
HepG2 while decreasing Bcl-2 production and up-regulation of Caspase 3, Caspase 9, and p53 in
U87 cells.

Conclusion::

It is concluded that Stylosin can probably inhibit the proliferation of the cancer cell
line by affecting the expression of genes involved in apoptosis and the production of ROS.
Genetic Similarity between Type 2 Diabetes and Breast Cancer: A Brief Report
Authors: Jana Sandipan , Chatterjee Suraj Kumar , Bala Asis , Haldar Pallab Kanti
Published: June 2024

Recent progress in genetics research has accelerated our comprehension of
complex disorders such as type 2 Diabetes Mellitus and breast cancer. Genome-wide
association studies on a large scale have facilitated our exploration of the underlying
pathology. Individuals with type 2 diabetes are at a higher risk of developing several
types of cancer as a result of common risk factors, such as obesity, poor diet, aging,
and low levels of physical activity. While several susceptibility genes have been
identified, we must consider tissue specificity and direction of effect when
investigating the shared genetic aetiology. Techniques such as Mendelian
randomisation allow us to unravel the link between the two diseases and answer critical
questions. By deconstructing the type 2 Diabetes GRS and studying genetic variants in
relation to their biological function, we may be able to evaluate the causal association
between different groups and various cancer types. Genetic research also has the
potential to investigate epigenetic modifications that contribute to the development of
cancer. This work explores the association between the genetic similarity between type
2 diabetes and breast cancer.
Impaired Glucose Metabolism and Oxidative Stress of Diabetes Mellitus in Causation of Breast Cancer
Authors: Khandelwal Bidita , Gupta Chamma , Byahut Abhishek
Published: June 2024

Breast cancer (BC) and Diabetes Mellitus (DM) are medical conditions that
are becoming more common in many developed nations. When compared with healthy
individuals, diabetic people have an elevated risk of BC and more fatalities from the
disease. This implies an association and that the two conditions share risk factors and
pathophysiological pathways. Although the causal processes beneath this connection
remain incompletely understood, plausible ties include hyperinsulinemia, insulin
resistance, oxidative stress, chronic inflammation, hyperglycaemia, and hormonal.
Each of these conditions has been proposed for fostering tumour progression in
numerous manners. Although hyperglycaemia is one of the most extensively
researched metabolic abnormalities in DM, the consequences of high blood sugar on
malignancy have garnered less scrutiny than the influence of insulin, insulin-like
growth factor-1 (IGF-1), oxidative stress, and chronic inflammation on the progression
of cancer. The purpose of this chapter is to provide insight into the link between
impaired glycaemic status and oxidative stress of DM with the causation, type,
progression, and mortality of BC. Several unexplored areas exist, and new hypotheses
may emerge in the days to come.
UJI MORTALITAS TIGA ISOLAT Metarhizium anisopliae DAN EKSTRAK TEMBAKAU TERHADAP HAMA ULAT PERUSAK DAUN (Plutella xylostella) (LEPIDOPTERA: PLUTELLIDAE) PADA TANAMAN KUBIS
Authors: Rosandy Devia Fitri , Syamsulhadi Mochammad , Widjayanti Tita
Published: June 2024

Penelitian ini bertujuan untuk mengetahui efektivitas tiga isolat jamur M. anisopliae dan ekstrak tembakau dengan kerapatan dan konsentrasi berbeda dalam mengendalikan populasi hama P. xylostella. Penelitian ini dilaksanakan pada bulan Oktober sampai Desember 2022 di Laboratorium Agens Hayati Brenjonk dan Laboratorium BPTPH Pasuruan. Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) dengan 16 perlakuan dan 4 kali ulangan. Setiap perlakuan menggunakan 15 ekor P. xylostella yang diuji untuk mengetahui mortalitas, daya hambat makan, LC50, dan LT50 dengan sidik ragam ANOVA dan analisis probit. Hasil penelitian menunjukkan bahwa mortalitas dan daya hambat tertinggi diperoleh dari isolat jamur koleksi Bojonegoro dan Jatisari dengan kerapatan 108 serta ekstrak tembakau konsentrasi 50 ml/L. Sedangkan nilai LC50 terbaik terdapat pada isolat jamur koleksi Jatisari yaitu 4,99% dan LT50 terbaik terdapat pada isolat jamur koleksi Bojonegoro yaitu 133,09 jam. Berdasarkan hasil penelitian menunjukkan bahwa ketiga isolat jamur M. anisopliae dan ekstrak tembakau memiliki kemampuan terbaik dalam menekan populasi hama P. xylostella.
PENURUNAN KEJADIAN DAN INTENSITAS PENYAKIT BUSUK PANGKAL BATANG AKIBAT JAMUR GANODERMA PADA BIBIT KELAPA SAWIT DENGAN APLIKASI MIKORIZA
Authors: Istiqomah Fatimah Nur , Novanto Praditya Rizqi , Sitanggang Marlon
Published: June 2024

Ganoderma boninense merupakan jamur patogen penyebab penyakit Busuk Pangkal Batang (BPB) pada tanaman kelapa sawit. Salah satu upaya pencegahan Ganoderma yaitu menggunakan agens hayati sejak dari pembibitan. Penelitian ini bertujuan untuk mengetahui kemampuan agens hayati mikoriza dalam menurunkan kejadian penyakit busuk pangkal batang akibat jamur Ganoderma pada bibit kelapa sawit dan mengetahui jumlah jenis spora, serta infeksi akar mikoriza. Penelitian ini dilakukan di green house menggunakan Rancangan Acak Lengkap (RAL) dengan 4 perlakuan dan 8 kali ulangan. Perlakuan yang diuji adalah 1) Kontrol, 2) Mikoriza, 3) Mikoriza + Ganoderma, 4) Ganoderma. Aplikasi mikoriza 20 g pada pre nursery dan 30 g di main nursery mampu menurunkan kejadian penyakit busuk pangkal batang akibat jamur Ganoderma sebesar 50,50% dan menurunkan intensitas serangan sebesar 49,96%. Jumlah spora pada bibit kelapa sawit yang diberi perlakuan mikoriza adalah 50,67 spora/10 g dan pada perlakuan mikoriza + Ganoderma adalah 25 spora/10 g. Terdapat 3 jenis spora yang ditemukan, yaitu Glomus sp1, Glomus sp2, dan Acaulospora sp. Infeksi akar bibit kelapa sawit umur 12 bulan yang diberi perlakuan mikoriza adalah 66,67%, sedangkan pada perlakuan mikoriza + Ganoderma adalah 33,33%.
Families as ecosystems
Authors: Castro Vasquez Isabel
Published: June 2024

To theorize and reimagine the contemporary web of family relations, this article maps and analyzes the family ecosystems in Rivasian fiction through an eco-critical lens. As one of the most salient contemporary Galician and Spanish authors, well known for his ecologically conscious writing, an ecocritical definition of family must take into consideration the imaginary proposed by his texts. That is, a non-anthropocentric rhizomatic imaginary of family relationships that questions and expands beyond traditional definitions of family as biological, heteropatriarchal and exclusively human.
To assault the hidden abode of reproduction
Authors: Monfort Bruno
Published: June 2024

The following article is intended to offer a historical account of the institution of the family in order to situate the abolitionist proposals and the Black feminist and queer critiques emerging during the second half of the twentieth century. The first section presents value-form readings of social reproduction, specially focusing on the 2013 article written by Maya González and Jeanne Neton, “The Logic of Gender”, to conceptualize the family as a “unit of privatised care”. Throughout the second section, the text lays out a periodisation of the emergence and historical changes that the family undergoes through the reconfiguring of social reproduction in a broader sense to locate the political approaches of the classical workers’ movement and its constitutive exclusions. Finally, the text presents two situated critiques of the family elaborated from its margins.
Nível de conhecimento dos professores sobre o TDAH nas escolas públicas estaduais de Rondônia, no Brasil
Authors: Silva Marcos Antônio Shreder da , Kristensen Christian Haag
Published: June 2024

O Transtorno de Déficit de Atenção e Hiperatividade (TDAH) é um transtorno prevalente na infância e na adolescência que apresenta desafios para os processos de ensino e aprendizagem. O objetivo deste estudo foi avaliar o nível de conhecimento dos professores das escolas públicas estaduais de Rondônia acerca do TDAH. A versão brasileira da Knowledge of Attention Deficit Disorders Scale (KADDS-Br) foi aplicada em 202 professores de 18 municípios de Rondônia. Análises descritivas e inferenciais foram conduzidas para explorar o grau de conhecimento, de equívocos e de lacunas sobre o TDAH, incluindo o escore total e três subescalas da KADDS-Br: características gerais, sintomas/diagnóstico e tratamento. Os professores que participaram do estudo evidenciaram um percentual de conhecimento sobre o TDAH de 52,67%, mas com relevantes equívocos (18,90%) e lacunas (28,48%). Em relação aos domínios específicos, o percentual de conhecimento apresentou alguma variabilidade, sendo mais evidente em relação aos sintomas/diagnósticos (69,54%) e menos proeminente sobre características gerais (46,45%) e tratamento (48,95%). O nível de conhecimento dos professores das escolas públicas estaduais de Rondônia sobre o TDAH é mediano, sugerindo a necessidade de formação específica sobre o transtorno.
Effectiveness of smartphone-based e-health intervention to promote cancer patients' quality of life: A quasi-experimental study
Authors:   Department of Nursing, College of Applied Medical Sciences, Shaqra University, Shaqra, Saudi Arabia, Saleh Manal Saleh Moustafa , Alenezi Atallah ,   Department of Nursing, College of Applied Medical Sciences, Shaqra University, Shaqra, Saudi Arabia, Alhowaymel Fahad ,   Department of Nursing, College of Applied Medical Sciences, Shaqra University, Shaqra, Saudi Arabia, Abaoud Abdulaziz ,   Department of Nursing, College of Applied Medical Sciences, Shaqra University, Shaqra, Saudi Arabia, Elsabahy Hanan El Said ,   Department of Nursing Administration, Faculty of Nursing, Mansoura University, Mansoura, Egypt, Fathi Riham Hashem ,   Faculty of Medicine, Zagazig University, Zagazig, Egypt, Taref Nagwa Nabeh ,   Department of Community Health Nursing, Faculty of Nursing, Mansoura University, Mansoura, Egypt
Published: June 2024

Cancer significantly affects patients' quality of life (QoL), impacting their physical, emotional, and social well-being. Recently, smartphone-based e-health interventions have been investigated as a method to improve QoL for cancer patients by providing customized support. This study assesses the effectiveness of these interventions. Using a quasi-experimental design, the research involved pre- and post-intervention tests. A total of 106 cancer patients were recruited through convenience sampling. A structured questionnaire was used, covering socio-demographic characteristics, medical history, cancer knowledge, and a QoL scale. Data were collected initially and two months after the intervention, which included lectures, group discussions, and scenario-based activities. Results indicated significant improvements in patients’ knowledge and QoL scores post-intervention. There were also notable differences in knowledge scores related to socio-demographic factors before and after the intervention. The findings suggest that smartphone-based e-health interventions effectively enhance cancer patients' knowledge and QoL. Successful implementation of these interventions can lead to better health outcomes. Continuous training for nurses and other healthcare providers is essential to maximize the benefits of e-health. This study highlights the potential of smartphone technology to support continuous care for cancer patients, potentially reducing hospital readmissions and improving self-care and health literacy.
National and international standards for the specific activity of Cs-137 in drinking water and agricultural products
Authors:   Russian Institute of Radiology and Agroecology of National Research Centre «Kurchatov Institute», Mirzoev E.B.
Published: June 2024

Comparative analysis of sanitary and hygienic requirements for the specific activity of Cs-137 in drinking water and agricultural products, such as grain, potatoes, root crops, milk, meat, fish, eggs established in Russia, Belarus the EAEU, Ukraine, Japan, China, European Union countries, the United States of America, Food and Agriculture Organization of the United Nations and the World Health Organization, revealed significant differences. It might be due to the use of various methodological approaches to justify permissible levels of Cs-137 in drinking water and agricultural products. However, there is only one criterion for the population of all countries: the radiation dose should not exceed 1 mSv/year. It follows that there is a need to clarify national and international standards for specific Cs-137 radioactivity in drinking water and agricultural products. Consequently, national and international standards for the specific activity of Cs-137 in drinking water and agricultural products need clarification and scientific justification based on unified methodological approaches. It is especially important for countries affected by accidents at the Chernobyl NPP (Russia, Belarus and Ukraine) and the Fukushima NPP 1 (Japan).
The significance of thyroxine in the processes of interaction of corticosteroids with plasma proteins on the model of resistance of irradiated animals with autotransplanted adrenal glands
Authors:   Patrice Lumumba Peoples' Friendship University of Russia, Omelchuk N.N.
Published: June 2024

The article is devoted to the study of the thyroxine effect on protein-steroid interaction in irradiated animals with autotransplanted adrenal glands. The relevance of the study is due to the need to study the radiobiological patterns of pituitary-thyroid regulation of protein-steroid interaction in acute radiation sickness in conditions of increased radioresistance of the body. The purpose of the work is to study the effect of thyroxine on the fractional composition of 11-hydroxycorticosteroids (11-OCS) and the binding capacity of corticosteroid binding globulin (CBG) in irradiated animals with autotransplanted adrenal glands. For experimental work 60 male rats weighing 200-220 g were used. Groups of animals with autotransplanted (experiment) and intact (control) adrenal glands were formed. Autotransplantation of the adrenal glands was performed according to the method of D. Ingle and G. Higgins. All animals were irradiated at a dose of 6.0 Gy. Animals in the experimental groups were administered 50 μg of thyroxine LD (Reanal, BP). Animals in the control groups were injected intraperitoneally an equal volume of physiological solution. To assess protein-steroid interactions, the fluorometric method, gel filtration method in the author's modification, a method for measuring the weight of the thymus were used. Conclusions were drawn about the effect of thyroxine on the protein-steroid interaction in radiation sickness using a model of resistance in irradiated animals with autotransplanted adrenal glands: 1) under the influence of thyroxine, the level of free 11-OCS in intact irradiated rats increases to a greater extent than the binding capacity of CBG; 2) administration of thyroxine to animals with autotransplanted adrenal glands causes an increase in the binding capacity of CBGs and a significant decrease in the concentration of free 11-OCS in the blood plasma; 3) the positive effect of thyroxine administration on increasing the weight of the thymus was manifested only in animals with autotransplanted adrenal glands; 4) an increase in the weight of the thymus in irradiated rats with autotransplanted adrenal glands under the influence of thyroxine is associated with a decrease in the content of unbound 11-OCS in the blood of animals.
A Universal Digital Stress Management Intervention for Employees: Randomized Controlled Trial with Health-Economic Evaluation
Authors: Freund Johanna , Smit Filip , Lehr Dirk , Zarski Anna-Carlotta , Berking Matthias , Riper Heleen , Funk Burkhardt , Ebert David Daniel , Buntrock Claudia
Published: June 2024

Background

Stress is highly prevalent and known to be a risk factor for a wide range of physical and mental disorders. The effectiveness of digital stress management interventions has been confirmed; however, research on its economic merits is still limited.

Objective

This study aims to assess the cost-effectiveness, cost-utility, and cost-benefit of a universal digital stress management intervention for employees compared with a waitlist control condition within a time horizon of 6 months.

Methods

Recruitment was directed at the German working population. A sample of 396 employees was randomly assigned to the intervention group (n=198) or the waitlist control condition (WLC) group (n=198). The digital stress management intervention included 7 sessions plus 1 booster session, which was offered without therapeutic guidance. Health service use, patient and family expenditures, and productivity losses were self-assessed and used for costing from a societal and an employer’s perspective. Costs were related to symptom-free status (PSS-10 [Perceived Stress Scale] score 2 SDs below the study population baseline mean) and quality-adjusted life years (QALYs) gained. The sampling error was handled using nonparametric bootstrapping.

Results

From a societal perspective, the digital intervention was likely to be dominant compared with WLC, with a 56% probability of being cost-effective at a willingness-to-pay (WTP) of €0 per symptom-free person gained. At the same WTP threshold, the digital intervention had a probability of 55% being cost-effective per QALY gained relative to the WLC. This probability increased to 80% at a societal WTP of €20,000 per QALY gained. Taking the employer’s perspective, the digital intervention showed a probability of a positive return on investment of 78%.

Conclusions

Digital preventive stress management for employees appears to be cost-effective societally and provides a favorable return on investment for employers.

Trial Registration

German Clinical Trials Register DRKS00005699; https://drks.de/search/en/trial/DRKS00005699
Examining the Relationships Between Indoor Environmental Quality Parameters Pertaining to Light, Noise, Temperature, and Humidity and the Behavioral and Psychological Symptoms of People Living With Dementia: Scoping Review
Authors: Au-Yeung Wan-Tai M , Miller Lyndsey , Wu Chao-Yi , Beattie Zachary , Nunnerley Michael , Hanna Remonda , Gothard Sarah , Wild Katherine , Kaye Jeffrey
Published: June 2024

Background

A common challenge for individuals caring for people with Alzheimer disease and related dementias is managing the behavioral and psychological symptoms of dementia (BPSD). Effective management of BPSD will increase the quality of life of people living with dementia, lessen caregivers’ burden, and lower health care cost.

Objective

In this review, we seek to (1) examine how indoor environmental quality parameters pertaining to light, noise, temperature, and humidity are associated with BPSD and how controlling these parameters can help manage these symptoms and (2) identify the current state of knowledge in this area, current gaps in the research, and potential future directions.

Methods

Searches were conducted in the CINAHL, Embase, MEDLINE, and PsycINFO databases for papers published from January 2007 to February 2024. We searched for studies examining the relationship between indoor environmental quality parameters pertaining to light, noise, temperature, and humidity and BPSD.

Results

A total of 3123 papers were identified in the original search in October 2020. After an additional 2 searches and screening, 38 (0.69%) of the 5476 papers were included. Among the included papers, light was the most studied environmental factor (34/38, 89%), while there were fewer studies (from 5/38, 13% to 11/38, 29%) examining the relationships between other environmental factors and BPSD. Of the 38 studies, 8 (21%) examined multiple indoor environmental quality parameters. Subjective data were the only source of environmental assessments in 6 (16%) of the 38 studies. The findings regarding the relationship between agitation and light therapy are conflicted, while the studies that examined the relationship between BPSD and temperature or humidity are all observational. The results suggest that when the environmental factors are deemed overstimulating or understimulating for an individual with dementia, the behavioral symptoms tend to be exacerbated.

Conclusions

The findings of this scoping review may inform the design of long-term care units and older adult housing to support aging in place. More research is still needed to better understand the relationship between indoor environmental quality parameters and BPSD, and there is a need for more objective measurements of both the indoor environmental quality parameters and behavioral symptoms. One future direction is to incorporate objective sensing and advanced computational methods in real-time assessments to initiate just-in-time environmental interventions. Better management of BPSD will benefit patients, caregivers, and the health care system.