bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Early and Late Clinical, Radiological and Scintigraphic Datas After Laparoscopic Pyeloplasty in Ureteropelvic Junction Obstruction
Authors: ARSLAN ALICI Çiğdem , TOKAR Baran , ALICI Umut , ILHAN, TURKEY Huseyin , ARDA Mehmet Surhan
Published: December 2022

Ureteropelvic junction obstruction(UPJO) causes inadequate transport of urine from the renal pelvis to the ureter. Laparoscopic pyeloplasty(LP) is increasingly preferred in patients with UPJO. We aimed to compare the clinical, radiological and scintigraphic findings before the treatment and the early and late progress of the patients underwent LP for UPJO. Sixty-eight cases underwent LP for UPJO(January 2010-May 2016) were included. Demographic characteristics, clinical findings, intraoperative characteristics, data on preoperative and postoperative clinical, radiological and scintigraphic follow-ups of the cases were evaluated retrospectively. LP was performed in 68 patients(51 males, 17 females) for UPJO. Twenty-four patients with antenatal hydronephrosis, 46 patients with abdominal pain, hematuria and urinary tract infection(UTI) findings were diagnosed with UPJO. Patients were preoperatively followed up by USG and DTPA-MAG3 imaging. During surgery, aberrant vessel in 13(19.1%) patients, malrotation in 4(5.8%) and polyp in one(1.4%) patient were detected. Thirteen patients(19.1%) underwent surgery with the transmesoolic approach, 55 patients(80.8%) underwent retrocolic surgery, 33 patients underwent laparoscopy-assisted extracorporeal pyeloplasty. In postoperative period, patients were followed up at 1st, 3rd, 6th months and in the first year with USG and at 6th months with DTPA-MAG3 imaging. Postoperative USG follow up showed a decrease in hydronephrosis(p<0.001), an increase in parenchymal thickness(p<0.001), and a decrease in caliceal dilatation(p<0.001). In scintigraphic data, renal function was increased but it is not statistically significant(p>0.05) and activated half-time was decreased(p<0.05) in postoperative period. LP is a surgical treatment method with successful results when performed with appropriate indications in experienced clinics.
Legal Policy of Anti-Corruption Supervisor Design: A New Anti-Corruption Model in Indonesia
Authors: Sunaryo Sidik , Nur Asrul Ibrahim
Published: December 2022

Corruption is a fact of life in Indonesia and has a significant negative impact. The malicious intention of corruption in Indonesia has normatively shifted in terms of its meaning, adjusting to its opportunity. However, the increase in corruption in Indonesia is not accompanied by a legal policy of anti-corruption supervisor design. This study analyzes the legal procedure of strengthening supervision for corruption prevention in realizing good governance. The results indicate that the derived meaning of malicious intention of corruption in the old order, new order, and reform era gradually reduces the significance of adversarial nature from the perspective of public morality and the state's ideology. The Corruption Eradication Commission has been given authority to prevent and prosecute criminal acts of corruption. Establishing anti-corruption institutions in the regions serves as an anti-corruption enforcement agency and a control and monitoring system for government administration in all agencies to achieve good governance.
Finding Religious Moderation on the Indonesian Endorsed Social Studies Textbooks: Critical Discourse Analysis
Authors: Solihah Ni'matus , Abid Nuskhan
Published: December 2022

Religious moderation manifests an attitude that is not excessive, neutral, and in a middle position. Religious moderation is crucial in a multi-ethnic, multi-cultural, and multi-religious society like Indonesia. This study aims to reveal how indicators of religious moderation are displayed in compulsory social science textbooks in Indonesia—using critical discourse analysis to analyze visual and verbal texts in textbooks. The results show that indicators of religious moderation such as national commitment, tolerance, non-violence, and accommodating to local culture have been included in social science textbooks, although in an unequal proportion. This textual study suggests that other researchers conduct textbook studies using different methods. So, various perspectives will be obtained that can be used as material for future textbook development policies.
Women’s volleyball performance indicators according to age category and teams’ final position in international competitions
Authors: Martín Marzano-Felisatti Joaquín , Priego Quesada José Ignacio Priego Quesada , José Franciso Guzmán Lujá José Franciso
Published: December 2022

The aim was to determine which performance indicators show significant differences in connection with age category and team’s level in women's international volleyball. The competitions analyzed were Senior Volleyball Nations League (n= 130 games) and U20 (n= 64 games) and U18 (n= 63 games) World Championships held in 2019. The results obtained in this study showed that inthe U18 category there were more errorsper set(U18 8.33vs. Senior 5.25 vs. U20 6.00errorspoints, p<.001) and greater serve effectiveness (U18 9.00% vs. Senior 6.00%vs. U20 7.00%, p<.001). In U20 there was a huge leap in quality with maximum values in block performance (U20 25.00%vs. Senior 15.00% vs. U18 15.00%, p<.001) and an increase in attack variables (U20 39.00%vs U18 33.00%, p<.001) accompanied by a decrease in errorspoints per set(U20 6.00vs U18 8.33errors points, p<.001) and serve effectiveness (U20 7.00%vs U18 9.00%, p<.001). In the Seniors category, there was a decrease in block effectiveness (Senior 15.00%vs U20 25.00%, p<.001) and an increase in attackspoints per set (Senior 13.30vs U20 12.00 vs U18 9.70points, p<.001). In the comparison between levels, more differences were detected when teams were further apart in the ranking, and attack and block effectiveness were the most relevant indicatorsin thethree-agecategory. Based on the findings of this study, we can determine performance indicators for each age category and level, allowing coaches and technical staff to establish new training strategies for their team’s improvement and success.
A generalização dos sedenios de Leonardo e Narayana
Authors: Vieira Renata Passos Machado , Alves Francisco Regis Vieira , Catarino Paula Maria Machado Cruz
Published: December 2022

Assim como ocorre para a sequência de Fibonacci, tem-se o processo de complexificação da sequência de Leonardo e Narayana, outras duas sequências não muito conhecidas na literatura Matemática. Desse modo, este trabalho apresenta de forma introdutória os sedenios de Leonardo e Narayana, realizando ainda a sua generalização para os números inteiros não positivos. Com isso, são estudadas algumas propriedades matemáticas inerente à esses números, abordando a sua respectiva forma matricial, função geradora, fórmula de Binet e dentre outros aspectos matemáticos. Para pesquisas futuras, busca-se uma investigação em torno da aplicação dos sedenios dessas duas sequências apresentadas, integrando com a área de física moderna.
Jogos com a desigualdade triangular
Authors: López Linares Juan
Published: December 2022

Jogos são ferramentas eficazes no processo de ensinoaprendizagem em determinados contextos. O presente trabalho compila oito atividades que podem ser desenvolvidas em diversos espaços da escola. O professor de Matemática pode convidar seus pares das áreas de Computação e Educação Física para executar os desafios como projeto multidisciplinar. Estuda-se a desigualdade triangular para formar ou não um triângulo, a Lei da Reflexão, o Problema do Cavaleiro, a tarefa do Removedor de Minas, a construção da Faixa de Pedestres, como atravessar um Rio Traiçoeiro, o Ponto de Fermat e o Problema de Fagnano. A estrutura de jogo justifica-se devido a existência de diversas possibilidades para cumprir uma tarefa. Cada jogador ou time deve encontrar determinada configuração que minimiza algum comprimento. Embora a desigualdade triangular seja um conteúdo clássico ela é pouco explorada nos livros de textos. Todos os links das figuras são disponibilizados de forma interativa no site do GeoGebra.
Comparação entre alguns modelos discretos de dinâmica populacional
Authors: Pellegrino Álvaro Leitão , Oliveira Renata Zotin Gomes de
Published: December 2022

A escolha de um modelo para o estudo do comportamento de uma determinada população depende de características intrínsecas da mesma. Neste trabalho apresentamos alguns modelos discretos de dinâmica populacional cujas taxas de crescimento dependem da própria população e possuem aspecto semelhantes, ou seja, são decrescentes à medida que a população aumenta. A existência de ponto de equilíbrio bem como sua estabilidade dependem dos parâmetros envolvidos e assim, uma análise da estabilidade é realizada.
The Characteristics of Sexual Behavior in Blind Men in Ganzhou, China
Authors: Huang Shaoming , Zhu Shenghuang , Liu Renfu , Xiong Chuanchuan , Liu Lixin , Huang Jiaguo , Qian Biao
Published: December 2022

Purpose: To provide more information about blind men for the study of andrology by characterizing their current sexual behavior.
Methods: A questionnaire-based cross-sectional study design was used, including questions on demographic characteristics of participants, access to sexual knowledge, perception of the sexual partners' beauty, and sexual arousal.Blind men were interviewed face-to-face by the trained investigator.
Results: A total of 54 participants returned a completed survey with average age of 40.57 ± 9.80 years old. Their sexual orientation were all heterosexual. 90.7% of the participants have had sexual experience. Only 16.7% of the participants have received sex education. Access to sexual knowledge was mainly through sounds from mobile phones, peer to peer communication, sounds of television and radio. Voice was the most frequent perception of the sexual partners' beauty, followed by figure, skin, and body fragrance. The results on the stimuli of sexual arousal showed that tactile sensation and auditory sensation in that order were the most frequent stimuli of sexual arousal.
Conclusion: The stimuli of sexual arousal in blind men are mainly mediated by sound and touch. Blind men understand their sexual partners' beauty through auditory, tactile, and olfactory sensation. Blind men in Ganzhou lack formal and systematic sex education.
Importance of urban green areas connectivity for the conservation of pollinators
Authors: Graffigna Sofia , González-Vaquero Rocío A. , Torretta Juan P. , Marrero Hugo J.
Published: December 2022

Urbanization is one of the main processes generating large changes on the Earth's surface. The remaining green spaces within cities can be of utmost importance for pollinator conservation. Through a systematic literature review, we evaluate how the connectivity of urban green areas (parks, gardens, squares, among others) in different cities can affect the richness and abundance of pollinators. We utilize a connectivity metric using satellite images corresponding to 241 urban green areas obtained from 20 published works. The green areas were classified in urban, peri-urban and non-urban according to their percentage of impervious surface estimated in each image. The metric relates the connectivity of green areas contained within images with a radius of 500 meters immersed within a city. Our study shows the richness and abundance of pollinators is positively correlated with the connectivity of green areas in sites with different degrees of urbanization, mainly in urban and peri-urban sites. Our results emphasize the importance of green spaces to maintain the pollinator’s community in cities, and suggest that proper design and/or management could improve conditions for these important insects.
Quality of life of patients with functional bowel disorders
Authors: zaimi yosra , Trabelsi Ghassen , Shimi Maha , MW Dougaz , ayadi shema , Mabrouk Emna Bel Hadj , Mouelhi Leila
Published: December 2022

Background and objectives : Functional bowel disorders are the most common digestive disorders. Although not life-threatening, they have a repercussion on the quality of life (QOL) of patients. The objective of our study was to measure the QOL of patients followed for IBS and to determine the factors associated with its alteration.
Methods : Our cross-sectional, monocentric and prospective study was carried out in the outpatient department between February 2019 and January 2020. QOL was measured via MOS SF-36 questionnaire translated to Tunisian dialect. An association between epidemiological and clinical factors and impaired QOL was sought by univariate statistical study.
Results: One hundred patients were included (mean age 50,53 years-old and sex-ratio 0,53). The average values of physical (PCS) mental (MCS) and global (SF36) QOL scores were 42,5%, 39,9% and 41,2% respectively. They were all below the general populations average values. The factors associated with an alteration in both the physical and psychological QOL were female sex, low level of education, unemployment or work in the private sector, low socioeconomic level, hypertension, hypothyroidism and overweight and obesity.
Conclusion : Functional bowel disorders affect the QOL of patients. The modifiable associated factor scan be the subject of preventive actions to optimize the management of this pathology.
On the Q statistic with constant weights in meta-analysis of binary outcomes
Authors: Kulinskaya Elena , Hoaglin David C.
Published: December 2022

Background: Cochran’s Q statistic is routinely used for testing heterogeneity in meta-analysis. Its expected value (under an incorrect null distribution) is part of several popular estimators of the between-study variance, τ2. Those applications generally do not account for estimation of the variances in the inverse-variance weights. Importantly, those weights make approximating the distribution of Q (more explicitly, QIV) rather complicated.
Methods: As an alternative, we are investigating a Q statistic, QF , whose constant weights use only the studies’ effective sample sizes. For log-odds-ratio, log-relative-risk, and risk difference as the measures of effect, we study, by simulation, approximations to distributions of QIV and QF , as the basis for tests of heterogeneity.
Results: The results show that: for LOR and LRR, a two-moment gamma approximation to the distribution of QF works well for small sample sizes, and an approximation based on an algorithm of Farebrother is recommended for larger sample sizes. For RD, the Farebrother approximations works very well, even for small sample sizes. For QIV , the standard chi-square approximation provides levels that are much too low for LOR and LRR and too high for RD. The Kulinskaya et al. (2011) approximation for RD and the Kulinskaya and Dollinger (2015) approximation for LOR work well for n ≥ 100 but have some convergence issues for very small sample sizes combined with small probabilities.
Conclusions: The performance of the standard χ2 approximation is inadequate for all three binary effect measures. Instead, we recommend using a test of heterogeneity based on QF and provide practical guidelines for choosing an appropriate test at the .05 level for all three effect measures.
Intensity-dependent gamma electrical stimulation regulates microglial activation, reduces beta-amyloid load, and facilitates memory in a mouse model of Alzheimer’s disease
Authors: Liu Qian , Contreras Adam , Afaq Muhammad Shan , Yang Weijian , Hsu Daniel K , Russell Michael , Lyeth Bruce , Zanto Theodore P. , Zhao Min
Published: December 2022

Background: Gamma sensory stimulation may reduce AD-specific pathology. Yet, the efficacy of alternating electrical current stimulation in animal models of AD is unknown, and prior research has not addressed intensity-dependent effects.
Objective: The intensity-dependent effect of gamma electrical stimulation (GES) with a sinusoidal alternating current at 40 Hz on Aβ clearance and microglia modulation were assessed in 5xFAD mouse hippocampus and cortex, as well as the behavioral performance of the animals with the Morris Water Maze.
Methods and Results: One hour of epidural GES delivered over a month significantly 1) reduced Aβ42 load in the AD brain, 2) increased microglia cell counts, decreased cell body size, increased length of cellular processes of the Iba1+ cells, and 3) improved behavioral performance (learning & memory). All these effects were most pronounced when a higher stimulation current was applied.
Conclusion: The efficacy of GES on the reduction of AD pathology and the intensity-dependent feature provides guidance for the development of this promising therapeutic approach.
A rare cause of mons pubis growing mass of a vulvar granular cells tumor – a Case Report
Authors: Domingues Sofia Jovina , Correia Lúcia , Sousa Vera , Mendes Ana , Rosa Filipa , Jorge Ana Francisca
Published: December 2022

Introduction: Granular cell tumor (GCT) is a rare clinical entity derived from Schwann cells of the outer sheath of the peripheral nerves, involving skin and subcutaneous tissue in most cases, but specifically GCT of the vulva is less frequent and labium majus is more prevalent site in vulva. The exact prevalence and pathogenesis of GCT haven’t been determined, but the risk of malignancy has been described at the rate of 2%. The authors report a case of 52-year-old postmenopausal woman, with a 2-year slow growth vulvar mass, without associated symptoms. On physical examination, a hard consistent and nodular subcutaneous mass, with 5 cm and located over the mons pubis was observed. Pelvic magnetic resonance identified a solid mass with irregular borders on subcutaneous tissue, upon mons pubis. An aspiration cytology was performed, suggesting a GCT leading a complete excision. Microscopically, GCT was compatible with a GCT without malignancy characteristics and the margins were negative.
Conclusion: This case reports a GCT on the mons pubis, whose rare location have only been reported in three cases. Despites its benign behavior, the unusual size conditioned a more aggressive surgical treatment and a multidisciplinary approach. During follow-up vulva and other anatomical locations should be carefully observed, because of its unusual local or extragenital recurrence.
Explaining Sexual Self-Care Status and its Predictor factors in Women Referring to Healthcare Centers of Sari, Iran, 2021
Authors: yazdani fereshteh , Simbar Masoumeh , HamzehGardeshi Zeinab , Zare Elham , Nasiri Malihe
Published: December 2022

Introduction: With the increase in the prevalence of non-communicable diseases and chronic health problems along with population growth, one of the definitions that is expanding is the ability to adapt and self-manage against diseases and self-care. Although there are several studies to examine self-care in medical conditions, there are not enough concepts and data related to sexual self-care. Therefore, the present study was conducted with the aim of explaining the status of sexual self-care and its predictor factors in women of reproductive age referring to healthcare centers.
Material and methods: This research was a cross-sectional study that was conducted on 400 women of reproductive age that referring to healthcare centers affiliated to Mazandaran University of Medical Sciences, Sari in 2021. Data were collected using personal-obstetric characteristics and sexual self-care questionnaires in women of reproductive age. Pearson correlation coefficients, independent t-test, one-way analysis of variance (ANOVA) and multiple linear regression model were used to analyze the data.
Results: The average total score of sexual self-care in reproductive age women participating in the research was 70.66% ± 12.52%. In addition, the ​​prevention of women's cancers and the prevention of unintended pregnancies obtained the lowest and highest scores, respectively. Factors such as age, education, education related to medical sciences, history of HIV testing, history of HPV vaccination, source of sexual information, method of contraception and infection-related action in a person can affect the level of sexual self-care in women. Based on the final regression model, education related to medical sciences (B = 5.46, P = 0.035), family income (B = 5.58, P = 0.025), prevention method (B = 10.127, P = 0.000) and action related to infection in the person (B = 12.27, P = 0.047) were the final predictors of sexual self-care score in reproductive age women.
Conclusion: Based on the findings of the study, development of self-care promotion programs for reproductive aged women are necessary in all areas of reproductive health, with a priority for women’s cancer prevention, and focusing on promoting education and related economic assistance. The results of this study can be available to experts and policy makers to design programs to promote sexual self-care in women.
Effects of Different Physiotherapy Modalities on Insomnia and Depression in Perimenopausal, Menopausal, and Post-menopausal Women: A Systematic Review
Authors: Lialy Hagar E. , Mohamed Malak A. , AbdAllatif Latifa A. , Khalid Maria , Elhelbawy Abdulrahman
Published: December 2022

Background

Menopause is the time that marks passing 12 months after last menstruation cycle in women between ages 40–50. Menopausal women have common symptoms such as: hot flashes, vaginal dryness, mood switching, depression and insomnia. The systematic review aims to determine the effects of different therapeutic and manual modalities on insomnia and depression in perimenopausal, menopausal, and post-menopausal women.

Methodology

After identifying our inclusion/exclusion criteria, adding our search term into 3 databases (PubMed, science open, and Cochrane), 3958 papers were identified. By using EndNote software, we excluded duplicates, unrelated, and non-full text papers. Thus, we included only 26 papers including 7 physiotherapy modalities: exercise, reflexology, footbath, walking, therapeutic and aromatherapy message, craniofacial message, and yoga.

Results

Most of the included modalities’ results showed a significant improvement in insomnia and depression symptoms in intervention group rather than control group.

Conclusion

Using non-pharmaceutical interventions such as physiotherapy have an overall positive impact on reducing insomnia and depression in menopause women.
Preparation, characterization and chromatographic evaluation of nickel oxide deposited silica stationary phase in hydrophilic interaction liquid chromatography
Authors: Guo Ying-Jie , Peng Xi-Tian , Yu Qiong-Wei , Feng Yu-Qi
Published: December 2022

Nickel oxide deposited silica stationary phase was prepared by liquid phase deposition and characterized. Its chromatographic performance was evaluated using several compounds such as typical polar compounds and benzimidazoles as probes. The effects of mobile phase variables such as acetonitrile content, salt concentration, and pH on the chromatographic behavior, thermodynamics, and kinetics of these compounds were investigated to reveal the retention mechanism. The results showed that the prepared stationary phase exhibited a retention behavior of hydrophilic interaction liquid chromatography, and that multiple retention mechanisms including partitioning, adsorption, ion-exchange, electrostatic attraction, and coordination interactions contributed to solute retention. The coordination of nickel oxide electron-accepting sites and the electron-donating solutes resulted in the mixed-mode retention on stationary phase, which could be very useful for enhancing the chromatographic selectivity for the analytes. The batch-to-batch reproducibility was acceptable with the relative standard deviations of probe retentionof less than 9.89%. The prepared nickel oxide deposited silica stationary phase was successfully employed for the separation of several compounds, and it showed better separation effect and different selectivity from silica column and commercial Zorbax NH2 column.
Outpatients prescribed with fluvoxamine around the time of COVID-19 diagnosis are not at a reduced risk of subsequent hospitalization and death compared to their non-prescribed peers: population- based matched cohort study
Authors: Trkulja Vladimir , Kodvanj Ivan
Published: December 2022

Purpose. To assess the effect of exposure to fluvoxamine around the COVID-19 diagnosis on subsequent hospitalizations and mortality in COVID-19 outpatients in a real-life setting.
Methods. Using nationwide administrative data, we identified adult COVID-19 outpatients diagnosed up to August 15, 2021 and conducted two cohort studies. Study 1 included subjects prescribed fluvoxamine around the index COVID-19 diagnosis (Cohort A), their peers suffering similar psychiatric difficulties but not prescribed fluvoxamine (Cohort B) and those free of psychiatric difficulties/treatments (Cohort C). Study 2 included subjects prescribed fluvoxamine (Cohort Fluvoxamine) and their peers prescribed paroxetine (Cohort Paroxetine). Cohorts were mutually exactly matched and incidence of COVID-19-related hospitalization, 30-day all-cause hospitalization and of COVID-19-related mortality was estimated.
Results. Of the 416030 first-episode outpatients, Study 1 included 1016 Cohort A, 95984 Cohort B and 275804 Cohort C patients. Matched Cohort A (n=749) vs. Cohort B (n=31336) relative risks (95%CI/CrI), frequentist and Bayes with skeptical, otpimistic and pesimistic priors, were: COVID-related hospitalization 1.37 (0.56-3.33), 1.15 (0.55-2.11), 1.03 (0.56.1.96) and 1.43 (0.63-2.94), respectively; 30-day all-cause hospitalization 1.88 (0.76-4.67), 1.76 (1.39-2.25), 1.76 (1.39-2.24) and 1.86 (1.43-2.38), respectively; COVID-19 related mortality 0.73 (0.35-1.55), 0.93 (0.53-1.76), 0.79 (0.40-1.54) and 0.88 (0.37-2.11), respectively. Matched Cohort A vs. C (866 vs. 222792) comparison yielded similar estimates, as did the matched Cohort Fluvoxamine vs. Paroxetine comparison in Study 2 (344 of 994 matched to 535 of 1796 patients).
Conslusion. Outpatients prescribed fluvoxamine around the time of COVID-19 diagnosis were not at a reduced risk of hospitalizations and mortality compared to their non-prescribed peers.
Evaluation of effective coverage for type 2 diabetes in Mexican primary care health information systems: a retrospective registry analysis
Authors: Gallardo-Rincón Héctor , Rios-Blancas Maria Jesus , Montoya Alejandra , Saucedo-Martínez Rodrigo , Morales-Juárez Linda , Mujica Ricardo , Cantoral-Preciado Alejandra , Idueta Lorena Suarez , Lozano Rafael , Tapia-Conyer Roberto
Published: December 2022

Background: As the leading cause of disability and the fourth leading cause of premature death in Mexico, type 2 diabetes (T2D) represents a serious public health concern. The incidence of diabetes has increased dramatically in recent years, and data from the Mexican National Health and Nutrition Survey (ENSANUT) indicate that many people remain undiagnosed. Persistent socioeconomic health care barriers exacerbate this situation, as T2D morbidity and mortality are worsened in vulnerable populations, such as those without social security. We evaluated the performance of public primary health centers (PHCs) in T2D medical attention through the measure of effective coverage (EC, a combined measure of health care need, use, and quality) at national, state, health jurisdiction, and municipality levels.
Methods: This retrospective analysis used blinded data recorded during 2017 in the Non-communicable Diseases National Information System (SIC) and T2D prevalence reported in 2018 ENSANUT to evaluate the EC achieved. We included individuals ≥20 years old without social security who did not declare the use of private health care services. Each EC component (need, use, and quality) was estimated based on the Shengelia adapted framework. The Kruskal–Wallis test was applied to evaluate the associations among EC quintiles and demographics.
Results: In 2017, 26.5 million individuals, aged ≥20 years, without social security, and without the use of private health care services, were under the care of 12,086 PHCs. The national prevalence of T2D was 10.3%, equivalent to 2.6 million people living with T2D in need of primary health care. Large contrasts were seen among EC components between and within Mexican states. We found that only 37.1% of the above individuals received health services at PHCs and of them, 25.8% improved their metabolic condition. The national EC was 9.3%, and the range (by health jurisdiction) was 0.2%–38.6%, representing a large geographic disparity in EC. We found an evident disconnect among need, utilization, and quality rates across the country.
Conclusions: Expansion and improvement of EC are urgently needed to address the growing number of people living with T2D in Mexico, particularly in states with vulnerable populations.
Cavernous sinus thrombosis linked to COVID-19 infection: a case report.
Authors: Geoffroy Bastien , grange Rémi , Boureille Pierre , Duvillard Cécile , Deloire Lucile , Boutet Claire , Grange Sylvain
Published: December 2022

Introduction:
The severity of SARS-CoV-2 virus infection is mainly related to its respiratory complications. However, it can also lead to numerous and varied thromboembolic events. Symptoms may include headache, fever, and neurological disorders. Since 2020, the clinical presentation of COVID-19 infection have become increasingly varied, leading in some cases to complex symptom associations, including numerous neurological symptoms. SARS-CoV-2 may lead to neurotropism which could reach the central nervous system and all cranial nerves. Cavernous sinus thrombosis is a rare condition, occurring as a complication of an ear, nose, and throat (ENT) or facial infection.
Case presentation:
A 73-year-old man without personal or family history of thrombosis, was referred to the emergency room for a sudden appearance of diplopia and ptosis, 3 days after testing positive for COVID-19 infection. An initial head CT-scan found no signs of stroke. He underwent a cerebral MRI 7 days later, which revealed a thrombosis of his right cavernous sinus. A brain CT scan follow-up 7 days later showed regression of the thrombosis with complete recanalization of the cavernous sinus. This was accompanied by a complete regression of diplopia and fever. He was discharged from the hospital 10 days after hospital admission.
Conclusions
In this case report, we describe a rare event of cavernous thrombophlebitis following a COVID-19 infection.
Atrial fibrillation incidence and outcomes in two cohorts of octogenarians: LiLACS NZ
Authors: Teh Ruth , Kerse Ngaire , Pillai Avinesh , Lumley Thomas , Rolleston Anna , Kyaw Tin Aung , Connolly Martin , Board Joanna , Monteiro Elaine , St-Clair Valerie Wright , Doughty Robert N
Published: December 2022

Background: Atrial fibrillation (AF), the most common cardiac arrhythmia in the general population, has significant healthcare burden. Little is known about AF in octogenarians.
Objective: To describe the prevalence and incidence rate of AF in New Zealand (NZ) octogenarians and the risk of stroke and mortality at 5-year follow-up.
Design: Longitudinal Cohort Study
Setting: Bay of Plenty and Lakes health regions of New Zealand
Subjects: Eight-hundred-seventy-seven (379 indigenous Māori, 498 non-Māori) were included in the analysis.
Methods: AF, stroke/TIA events and relevant co-variates were established annually using self-report and hospital records (and ECG for AF). Cox proportional-hazards regression models were used to determine the time dependent AF risk of stroke/TIA.
Results: AF was present in 21% at baseline (Māori 26%, non-Māori 18%), the prevalence doubled over 5-years (Māori 50%, non-Māori 33%). 5-year AF incidence was 82.6 /1000-person years and at all times AF incidence for Māori was twice that of non-Māori. Five-year stroke/TIA prevalence was 23% (22% in Māori and 24% non- Māori), higher in those with AF than without. AF was not independently associated with 5-year new stroke/TIA; baseline systolic blood pressure was. Mortality was higher for Māori, men, those with AF and CHF and statin use was protective.
In summary, AF is more prevalent in indigenous octogenarians and should have an increased focus in health care management. Further research could examine treatment in more detail to facilitate ethnic specific impact and risks and benefits of treating AF in octogenarians.
In House Generated SSR markers Reveals Genetic Variation and Population Structure in the Germplasm and Identification of Trait-Specific Markers that Enables Efficient Plant Breeding Program in Moringa (Moringa oleifera)
Authors: Paul Allen Eldho , M Williams , R Ajay Prasanth , Ranjani Veera , M Raveendran , Boopathi Manikanda
Published: December 2022

Moringa oleifera Lam. leaves are rich in nutritionally and therapeutically important bioactive compounds. As the knowledge on natural population genetic diversity is a prerequisite for further leaf biomass improvement, the morphological and molecular diversity were assessed among 55 South Indian ecotypes of M. oliefera. Leaf traits such as leaf length, breadth, fresh weight, dry weight and number of leaves were evaluated for morphological diversity and for genetic diversity, a total of 116 Simple Sequence Repeats (SSR; including 75 Genomic- and 41 Genic-SSR) were used. Polymorphic information content (PIC) for those SSRs had ranged from 0.0 (for SSR19876) to 0.96 for (SSR25987) with an average of 0.886. The heterozygosity ranged from 0.0 to 0.96 with an average of 0.215 and those allelic data clustered the investigated accessions into three main clusters using the Unweighted Pair Group Method with Arithmetic mean (UPGMA). Analysis of molecular variance (AMOVA) indicated that 71% of diversity was attributed to differences among individuals of population. Cluster analysis, Principal coordinate analysis (PCoA) and structure-based population study showed that, there was no geographical distribution among the genotypes. Marker-trait associations was also implemented with general and mixed linear models and 65 SSR markers were found to be associated with investigated leaf traits at p < 0.05. Among them, six SSRs were linked to the investigated leaf biomass traits with more than 70% influence on the expression of those traits and shown to have putative functions in leaf biomass, which would be potential candidates for molecular breeding in Moringa.
PVT1 Inhibition Stimulates Anti-tumor Immunity, Prevents Metastasis, and Depletes Cancer Stem Cells in Squamous Cell Carcinoma
Authors: Qin Zhen , Zhang Wenbo , Liu Shuo , Wang Yujia , Peng Xin , Jia Lingfei
Published: December 2022

Cancer stem cells (CSCs) cause tumor metastasis and immune evasion by asyetunknown molecular mechanisms. In the present study, we identify a long noncoding RNA (lncRNA), termed PVT1, which is highly expressed in CSCs and correlated closely with lymphoma node metastasis of head and neck squamous cell carcinoma (HNSCC). PVT1 inhibition eliminates CSCs, prevents metastasis, and stimulates anti-tumor immunity, while inhibiting HNSCC growth. Moreover, PVT1 inhibition promotes the infiltration of CD8+ T cells into the tumor microenvironment, thereby enhancing immunotherapy by PD1 blockade. Mechanistically, PVT1 inhibition stimulates the DNA damage response, which induces CD8+ T cellrecruiting chemokines, while reducing CSCs and metastasis via regulating the miR-375/YAP1 axis. In conclusion, targeting PVT1 might potentiate the elimination of CSCs via immune checkpoint blockade, prevent metastasis, and inhibit HNSCC growth.
Surgical treatment of rare pediatric cardiac myxomas:12 years clinical experience in a single institution
Authors: Zhao Shengliang , Li Hua , Wu Chun , Pan Zhengxia , Wang Gang , Dai Jiangtao
Published: December 2022

Background
Primary cardiac tumors are very rare, especially in children. Cardiac myxomas(CM) constitute the major proportion among these masses.Most of the reports in the literature are case reports.This study summarizes our 12-year clinical experience with surgical treatment of CM.
Methods
We retrospectively analyzed the clinical data of 23 children with CM(8 boys, 15 girls; median age: 8.92 months, range: 2 years 5 months-12 years 9 months; body weight: 11kg-45kg, median body weight: 28.21kg) admitted to our hospital in the previous 12 years, and we statistically analyzed their clinical manifestations and surgical methods.
Results
23 cases underwent myxoma excision under cardiopulmonary bypass(CPB), 16 cases directly underwent foramen ovale suture closure, 7 cases underwent pericardial patch repair due to large atrial septal defect, 3 cases underwent mitral valve repair, and 2 cases underwent tricuspid annulus contraction.The postoperative course was uneventful in most patients. A few patients had some complications.There were 8 cases of postoperative arrhythmia and 4 cases of postoperative low cardiac output syndrome.23 cases were followed up for 0.2 to 12.6 years, and 1 case with cerebral infarction combined with hemiplegia of the right limb recovered well after rehabilitation treatment.The 22 children had no cerebral embolism, acute heart failure, atrioventricular block and other related complications.There was no recurrence of CM in 22 cases, and all recovered after surgery.One patient recurred 5 years after the operation, and no tumour recurrence was observed after the second operation.One patient (4.35%) died due to myocardial infarction in early postoperative period with persistent low cardiac output.
Conclusions
Although CM in children is rare, it may cause cerebral infarction and other multi-organ embolism.Once CM is found, it must be surgically removed as soon as possible, which can not only reduce serious complications, but also has the possibility of curing.If the complete resection is possible, surgery provides better palliation and can possibly double survival.Follow-up echocardiographic should be paid attention to after surgery.
A note on promising early coloring apple bud sports identified from commercial exotic apple germplasm
Authors: Singh Dinesh , Chauhan Neena , Chauhan Akriti
Published: December 2022

Somatic mutations (bud sports) add to the genetic variability in many crop species through outcrossing, sexual recombination, polyploidy etc. and consequently alters the overall reproductive growth characteristics, out of which most frequently expressed one is the fruit colour sport. The commercial significance of red colour in apples has generated an increasing interest in the enhanced colour found in apple sports. Many sports of ‘Red delicious’ and 'Gala' have been spoted and of these a number are believed to have enhanced red colour. Keeping in view, present investigations were undertaken to find early coloring bud mutations in different apple growing pockets of Shimla district of Himachal Pradesh, India. The research led to the identification of two early colouring bud sports i.e “Kanwar Red” originating from cv. Red Delicious and “Vance Early” originating from cv. Vance Delicious. “Kanwar Red” was found to be early in colouring with marked presence of lenticels scattered on the blushed fruit as compared to the striped fruits of mother variety. In “Vance Early” earliness and high intensity of colouring with the further exception of darker final colour in comparison to the mother variety was found. Apart from these, the bud mutants also differs in several physical and biochemical fruit characters. The commercialization of such bud sports will lead to a reduction in the use of coloring chemicals for fetching early market apart from creating a valuable gene pool which can be used in future breeding programme to develop early colouring strains in apple.
Fast Forward: Influencing the future in virtual reality increases real-life pro-environmental behaviour
Authors: Plechatá Adéla , Hielkema Marijke , Merkl Lisa-Marie , Makransky Guido , Frøst Michael Bom
Published: December 2022

To reach necessary greenhouse gas (GHG) emissions targets, behavioural change is necessary at the consumer level. Nevertheless, behavioural interventions have only a limited impact on habitual behaviours such as beef consumption, which significantly contributes to the GHGs released. Immersive virtual reality (VR) in the metaverse can transform the current information-based environmental communication into more experience-based communication. To study how such a shift might change the environmental communication effectiveness, we randomly assigned N = 168 participants to a VR experience (experiencing and influencing future climate change scenarios based on food choices) or a VR information condition (receiving the same information from a virtual human). After the VR intervention, participants chose in real life between three meal options: beef Bolognese, 50% reduced Bolognese, and vegetarian Bolognese. To test the effectiveness of nudging in form of labelling on promoting plant-based diets, we randomly labelled the vegetarian dish with explicit or indulgent labels. The preference for a vegetarian meal did not differ across the labelling conditions. The VR experience led to higher intentions to reduce meat consumption and more pro-environmental behaviour in VR and real life as compared to the information condition. Mediation analyses confirm that experiential VR environmental communication can increase people’s efficacy beliefs, which increase their intentions and, consequently, lead to a reduction in beef consumption. Implications for future environmental communication are outlined.
FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway
Authors: Cong Weitao , Tong Gaozan , Chen Yiming , Chen Xixi , fan junfu , Zhu Kunxuan , hu Zijing , Li Santie , zhu junjie , feng jianjun , wu zhaohang , hu zhenyu , zhou bin , jin litai , shen jingling , Li Xiaokun
Published: December 2022

Hepatic ischemia-reperfusion injury (IRI) is a common complication that occurs during hepatic resection and liver transplantation. However, the mechanisms underlying hepatic IRI have not been fully elucidated. Here, we aimed to explore the role of fibroblast growth factor 18 (FGF18) in hepatic IRI and the underlying mechanisms. In this work, we found that FGF18 was upregulated in the livers of human and mice subjected to IRI. Hepatic stellate cells (HSCs) secreted FGF18 and protected against IRI-induced hepatocytes apoptosis, inflammation and oxidative stress. Liver-specific FGF18 overexpression effectively alleviated I/R-induced liver injury, while aggravated in mice with HSCs-specific FGF18 deletion. Mechanistically, FGF18 treatment reduced the mRNA and protein levels of ubiquitin carboxyl-terminal hydrolase 16 (USP16), leading to increased ubiquitination levels of Kelch Like ECH Associated Protein 1 (KEAP1) and the activation of nuclear factor erythroid 2-related factor 2 (Nrf2). In addition, USP16 interacted and deubiquitinated KEAP1 via K48-linked ubiquitination. More importantly, FGF18-induced Nrf2 directly bound to the promoter of USP16 and thus formed a negative feedback loop with USP16. Collectively, our results show that FGF18 alleviates hepatic IRI mainly by elevating the ubiquitination level of KEAP1 via downregulation of USP16 and thereby activating the Nrf2 signaling pathway, suggesting that FGF18 may represent a promising therapeutic approach for hepatic IRI.
Automated Malware Analysis in Internet of Things based Systems: A Deep Learning Approach
Authors: Khapre Sapna , R Ganeshan
Published: December 2022

Numerous potentials are presented by the Internet of Things, but there are a number of drawbacks as well. IoT devices have recently been more frequently the subject of malware assaults. Deep Learning is a popular technique that is used to identify and classify viruses. Researchers are working to strengthen the security of gadgets that are connected to the Internet in this respect. This approach used the behaviour of malware during run-time in the context of system calls to identify it. The real-time IoT malware samples were given by IOTPOT, a honeypot that replicates a variety of IoT device CPU architectures. From the malicious system calls that are generated, a deep learning algorithm extracts the necessary characteristics. To better understand malware activity, RGB photos were transformed and behavioural data was used to depict the samples. The retrieved system calls were divided into two groups—normal and malicious sequences—using VGG-19 (Visual Geometry Group – 19). The two classes were then assigned to each of the 15 subclasses of malware. The model is made lightweight and computationally efficient utilising a two-step feature extraction method that uses complete vector features for classification and lightweight dynamic features for weighting. The efficiency of deep learning is assessed using a range of performance criteria. In comparison to previously developed approaches, we were able to achieve an average classification accuracy of 97.75%, an increase of 3.7%.
Psychometric properties of the Hungarian Childhood Trauma Questionnaire Short Form and its validity in patients with adult Attention-Deficit Hyperactivity Disorder or Borderline Personality Disorder
Authors: Kenézlői Eszter , Csernela Eszter , Nemoda Zsófia , Lakatos Krisztina , Czéh Boldizsár , Unoka Zsolt , Simon Mária , Réthelyi János
Published: December 2022

Background
A convincing body of research has identified childhood traumatization as an important etiological factor for psychiatric disorders, including adult attention-deficit hyperactivity disorder (aADHD) and borderline personality disorder (BPD). The aim of this study was to examine the psychometric properties of the Hungarian version of the Childhood Trauma Questionnaire Short Form (H-CTQ-SF) and to investigate the differences between patients diagnosed with aADHD and BPD in terms of early traumatization.
Methods
Altogether 765 (mean age = 32.8 years, 67.7% women) patients and control subjects were enrolled from different areas of Hungary. Principal component analysis and confirmatory factor analysis were carried out to explore the factor structure of H-CTQ-SF, and test the validity of the five-factor structure. Discriminative validity was assessed by comparing clinical and non-clinical samples. Subsequently, aADHD and BPD subgroups were compared with healthy controls to test for alterations in aADHD not attributable to comorbid BPD, by excluding comorbid cases. Convergent validity was explored by measuring correlations with subscales of the Personality Inventory for DSM-5 (PID-5).
Results
The five scales of the H-CTQ-SF demonstrated adequate internal consistency and reliability values. The five-factor model fit the 27-item Hungarian version well, after the removal of one item from the physical neglect scale because of its cross loading onto the emotional neglect subscale. The H-CTQ-SF effectively differentiated between the clinical and non-clinical samples. The BPD group showed significant differences in each CTQ domain compared to the healthy control group, while there were no such differences in the aADHD group. All CTQ domains, except for physical abuse, demonstrated medium to high correlations with PID-5 emotional lability, anxiousness, separation insecurity, withdrawal, intimacy avoidance, anhedonia, depressivity, suspiciousness, hostility subscales.
Conclusions
This study provides data about the psychometric properties of the H-CTQ-SF, an easy-to-administer, non-invasive, ethically sound questionnaire. In aADHD patients without comorbid BPD, low levels of traumatization in every CTQ domain are demonstrated comparable to healthy control individuals. Thus, elevated level of traumatization found in former studies of aADHD might be a consequence of comorbid BPD. Our findings also support the role of emotional neglect, emotional abuse and sexual abuse in the development of BPD.