bluuebunny/crossref_metadata_2025 huggingface dataset:
IDENTIFIKASI KEKAR DESA PATTONTONGAN KECAMATAN MANDAI KABUPATEN MAROS, SULAWESI SELATAN
Authors: Hasan Agung , Simanjorang De Leonard Pasteur , Nursalim Islamiah , Syihab Mufly Fadla , Karepesina Nur Lailiah , Sanjaya Ervin Budi , Sadilah Sadilah , Ramlan Muhammad Azhari , Ariansyah Muh Resky , Massinai Muhammad Altin , Ismullah Massinai Muhammad Fawzy
Published: July 2020

Pelaksanaan kegiatan survey telah dilakukan di sekitar daerah pertambangan di Desa Patontongan, Kecamatan Mandai, Kabupaten Maros, Sulawesi Selatan. Pada penelitian ini, pengukuran dilakukan berulang kali dengan menggunakan alat yaitu kompas geologi. Hasil pengukuran di lapangan diperoleh beberapa nilai strike-dip pada lokasi struktur kekar yang berbeda, sehingga pada daerah tersebut mengiindikasikan terdapat kekar. Data strike-dip yang diperoleh kemudian diolah menggunakan software DIPS untuk menghasilkan Diagram Rosette. DIPS digunakan untuk melakukan analisis orientasi data geologi dan juga berhubungan dengan analisis teknik struktur batuan. Hasil Diagram Rosette memperlihatkan bahwa arah jurus kekar yang terdapat di Desa Patontongan ini mengarah hampir Utara-Selatan serta berarah Timur Laut-Barat Daya. Dengan melihat Diagram Rosette maka dapat disimpulkan gaya pembentuk struktur pada lokasi tersebut berarah Barat-Laut Tenggara.
IDENTIFIKASI ZONA SHALE PROSPEKTIF BERDASARKAN DATA WELL-LOG DI CEKUNGAN SUMATRA SELATAN
Authors: Jamaluddin Jamaluddin , Maria Maria
Published: July 2020

Kebutuhan bakan bakar fosil terutama minyak dan gas bumi terus meningkat, akan tetapi jumlah cadangan bahan bakar fosil semakin menurun sehingga terdapat ketidakseimbangan antara kebutuhan dan persediaan. Salah satu alternatif ketahanan energi nasional yaitu beralih dari sumber daya konvensional ke non-konvensional seperti shale gas dan shale oil. Penelitian tersebut bertujuan untuk mengidentifikasi zona serpih prospektif pada sumur JML-1 berdasarkan data rekaman sumur. Penentuan zona shale prospektif diidentifikasi menggunakan pendekatan metode ∆LogR (Metode Passey’s) dengan melakukan overlay antara log sonik dan log resistivitas. Berdasarkan pendekatan metode Passey, Sumur JML-1 teridentifikasi 4 (empat) zona shale prospektif yang memiliki tingkat kekayaan organik (TOC) 0.72 - 6.12% wt. Cekungan Sumatra Selatan memiliki potensi cadangan shale yang cukup besar sehingga dibutuhkan integrasi beberapa metode untuk mengevaluasi lebih dalam.
PENGARUH KONDISI GEOLOGI LINGKUNGAN TERHADAP POTENSI AIR TANAH DALAM DI KOTA MAKASSAR
Authors: Umar Emi Prasetyawati , Nawir Alfian , Jamaluddin Jamaluddin , Nurfalaq Aryadi
Published: July 2020

Seiring dengan pesatnya perkembangan teknologi dan jumlah penduduk serta kemajuan pembangunan di segala aspek kehidupan, pemenuhan kebutuhan akan sumber daya air juga semakin meningkat. Salah satu aspek yang mempengaruhi potensi air tanah dalam adalah kondisi geologi suatu daerah. Berdasarkan hasil penelitian, penilaian geologi terhadap potensi air tanah dalam pada daerah penelitian tersebut terdiri dari morfologi pedataran bergelombang dan morfologi fluvial, satuan batuan terdiri satuan tufa, satuan aglomerat (dan breksi vulkanik) dan satuan aluvial, struktur geologi adalah kekar gerus. Airnya jernih dan memiliki nilai pH 7- 8 dan memenuhi syarat untuk kebutuhan air bersih
PEMODELAN BAWAH PERMUKAAN BANTAR KARET, JAWA BARAT MENGGUNAKAN METODE GRAVITASI
Authors: Jamaluddin Jamaluddin , Maria Maria , Ryka Hamriani , Afifah Rohima Sera
Published: July 2020

Gravity method is one of the geophysical methods that is often used to obtain information about the subsurface through differences density of the rocks around it. Gravity anomaly data used in this study is primary data that has been processed data. Data processing is obtained by reducing gravity observation data until complete bouguer anomaly values. The results of the interpretation of the gravity anomaly show that the types of rocks in subsurface of the study area are peridotite, tuff, riolite and basalt. The rock with the highest density is peridotite with a density value of 3.15 gr/cm3. This is due to the intrusion process to forming peridotite and there are two zones boundaries which have very significant density differences.
DISTRIBUSI PENGALIRAN PRESIPITASI BERDASARKAN TOPOGRAFI
Authors: Amalia Rahmi Rizqi , Sakka Sakka , Suriamihardja Dadang Ahmad
Published: July 2020

Penelitian ini menduga bahwa distribusi curah hujan berinteraksi langsung dengan bentuk topografi, sehingga dapat memperkirakan arah aliran dan besar debit aliran di sungai. Bentuk topografi dapat menunjukkan arah aliran dari dataran tinggi ke dataran rendah. Adapun tujuan penelitian ini adalah memetakan kontur distribusi curah hujan, kontur topografi, arah aliran permukaan, dan menghitung debit aliran permukaan di lokasi penelitian. Data yang dikumpulkan dalam penelitian ini merupakan data sekunder, yaitu data curah hujan dan hari hujan yang berasal dari BMKG, data topografi DEM SRTM yang berasal dari LAPAN, data shapefile batas DAS, sungai dan peta penggunaan lahan yang berasal dari Badan Informasi Geospasial (BIG). Hasil dari pemetaan kontur curah hujan pada tahun 2012 hingga 2017 menunjukkan nilai terendah 327 mm/tahun hingga nilai tertinggi 5346 mm/tahun, hasil pemetaan kontur topografi menunjukkan nilai terendah 745 meter dan nilai tertinggi 4279 meter, hasil dari pemetaan arah aliran menunjukkan bahwa aliran akan bergerak terus menuju sungai-sungai besar beserta cabangnya, dan hasil dari perhitungan debit maksimum terjadi pada bulan Januari yang terletak pada DAS Sungai Jeneberang dengan nilai 1,77 liter/detik dan nilai debit minimum terjadi pada bulan Agustus yang terletak pada DAS Binangapapa dengan nilai 0,07 liter/detik.
IDENTIFIKASI BATUAN BAWAH PERMUKAAN DAERAH LONGSOR KELURAHAN KAMBO KOTA PALOPO MENGGUNAKAN METODE GEOLISTRIK KONFIGURASI DIPOLE-DIPOLE
Authors: Nurfalaq Aryadi , Jumardi Andi
Published: July 2020

Penelitian ini bertujuan untuk mengidentifikasi batuan bawah permukaan daerah longsor di Kelurahan Kambo berdasarkan data resistivitasnya. Dalam penelitian ini dilakukan beberapa tahapan penelitian yaitu pembuatan peta kemiringan lereng menggunakan citra SRTM, Survey lapangan untuk pemetaan daerah titik longsor dan survey geolistrik konfigurasi dipole-dipole untuk mengetahui batuan bawah permukaan. Dari hasil penelitian diperoleh bahwa lokasi penelitian memiliki kemiringan lereng landai-curam. Di beberapa titik terdapat longsoran berupa longsor rayapan dan translasi. Batuan bawah permukaan terdiri dari batuan nilai resistivitas 9,5 – 105 Ohm.m berada pada permukaan hingga kedalaman 10 m. Lapisan ini merupakan lapisan batuan berupa lempung hasil pelapukan batuan basal, kenampakan lapangan berwarna cokelat. Lapisan di bawahnya merupakan lapisan batuan yang lebih keras yang memiliki nilai tahanan jenis 105 – 2571 Ohm.m. Batas antara kedua lapisan ini merupakan bidang gelincir longsor dengan nilai resistivitas 233 Ohm.m.
Bisakah Alam Menjadi Subyek Hukum? Refleksi Atas Beberapa Pengalaman
Authors: Prabowo Rian Adhivira , Seno Adi , Setiawan Fajar Ahmad , Herlambang Unu P. , Ermansyah Edho R. , Ginting Gerry Pindonta
Published: July 2020

Tulisan ini membahas mengenai tiga preseden hukum di Ekuador, Selandia Baru, dan India dalam hal penyematan subyek hukum kepada alam. Ekuador memberikan hak-hak tertentu untuk alam yang dicantumkan dalam amandemen konstitusi tahun 2008, Sungai Whanganui di Selandia Baru menjadi subyek hukum melalui proses legislasi, dan dua putusan di HC Uttarakhand India yang memutuskan Sungai Gangga, Sungai Yamuna, beserta seluruh atributnya dari hulu hingga hilir sebagai subyek hukum. Tiga perkembangan alam sebagai subyek hukum tersebut bisa dibilang merupakan perkembangan penting dalam studi mengenai “legal person” setelah perempuan dan korporasi yang terjadi beberapa dekade belakangan. Tulisan ini berisikan deskripsi atas preseden yang terjadi di tiga negara diatas beserta dengan eksplorasi atas kelemahan-kelemahan yang mungkin timbul dengan menyematkan alam sebagai subyek hukum.
The Dual-Reciprocity Boundary Element Method Solution for Gas Recovery from Unconventional Reservoirs with Discrete Fracture Networks
Authors: Zhang Miao , Ayala Luis F.
Published: July 2020

In this paper, we present a novel application of the dual-reciprocity boundary-element formulation (DRBEM) to model compressible (gas) fluid flow in tight and shale-gas reservoirs containing arbitrary distributed finite- or infinite-conductivity discrete fractures. Compared with the standard boundary-element method (BEM), the DRBEM transforms the nonlinear domain integrals at the righthand side (RHS) of BEM formulations for nonlinear partial differential equations into equivalent boundary integrals. This transformation allows retention of the domain-integral-free, boundary-integral-only character of standard BEM approaches. The proposed approach is based on coupling DRBEM with the finite-volume method (FVM) in which a multidimensional system is solved by integrating over a line with random fractures. The resulting system of equations is solved simultaneously for fracture and matrix boundary conditions by combining DRBEM and FVM without invoking any approximation for pressure-dependent nonlinear terms such as gas viscosity and compressibility. Numerical examples and field cases are presented to test the validity and showcase the capabilities of the proposed approach. The proposed model provides a general framework that can be applied to a variety of well and fracture geometries and operating schedules, and it is used to analyze production behavior for these complex systems. To the best of the authors’ knowledge, this is the first successful application of the dual-reciprocity principle to the BEM analysis of massively fractured horizontal wells (MFHWs) performance in natural-gas formations in which nonlinear, pressure-dependent gas properties are captured without approximation.
Some evidence that seasonal malaria chemoprevention with SPAQ has an effect on blood stage antibody responses and pre-erythrocytic stage of Plasmodium falciparum infections in Niger.
Authors: Moustapha Lamine Mahaman , Adamou Rafiou , Ibrahim Maman Laminou , Padounou Mariama Abdoulaye Louis , Diallo Abdoulaye , Courtin David , Testa Jean , NDiaye Jean Louis
Published: July 2020

Background: In endemic areas, children develop slowly and naturally develop anti-Plasmodium antibodies and become semi-immune. Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine + amodiaquine (SPAQ) is a new strategy to reduce malaria morbidity in young children in West Africa. However, SMC may impact on the natural acquisition of anti-Plasmodium immunity. We evaluated the effect of SMC with SPAQ on malaria antibody concentration in Niger.Methods: This survey was conducted in areas targeted with SMC since 2014 (Zinder district), without SMC (Dosso district), and with one year SMC 2016 (Gaya district). To assess the relationship between SMC and P. falciparum IgG antibody responses, we compared total antibody concentrations against two P. falciparum asexual stage vaccine candidate antigens, circumsporozoite protein (CSP) and glutamate-rich protein R2 (GLURP-R2), in children aged 3-59 months across the three sites. Antibody concentrations were quantified using an enzyme-linked immunosorbent assay (ELISA) on the elution extracted from positive and negative RDT cassettes.Results: A total of 229 children aged 3-59 months were included in the analysis: 71 in Zinder, 77 in Dosso, and 81 in Gaya. In Zinder (CSP=17.5µg/ml and GLURP-R2=14.3µg/ml) median antibody concentration observed were higher than in Gaya (CSP=7.7 µg/ml and GLURP-R2=6.5 µg/ml) and Dosso (CSP=4.5 µg/ml and GLURP-R2=3.6 µg/ml) (p<0.0001). Conclusion: We have some evidence that seasonal malaria chemoprevention with SPAQ has an effect on blood stage antibody responses and pre-erythrocytic stage of Plasmodium falciparum infections in Niger. Future studies are necessary to provide better understanding of the effect of on malaria immunity.
A Cluster Randomized Trial of Delivery of Intermittent Preventive Treatment of Malaria in Pregnancy at the Community Level in Burkina Faso
Authors: Gutman Julie , Stephens Daniel K , Tiendrebeogo Justin , Badolo Ousmane , Dodo Mathurin , Burke Danielle , Williamson John , Vibbert Kristen , Youll Susan J , Savadogo Yacouba , Brieger William R.
Published: July 2020

Background: Malaria in pregnancy is responsible for 8–14% of low birth weight and 20% of stillbirths in sub-Saharan Africa. To prevent these adverse consequences, the World Health Organization recommends intermittent preventive treatment of pregnant women (IPTp) with sulfadoxine-pyrimethamine be administered at each ANC visit starting as early as possible in the second trimester. Global IPTp coverage in targeted countries remains unacceptably low. Community delivery of IPTp was explored as a means to improve coverage. Methods: A cluster randomized, controlled trial was conducted in 12 health facilities in a 1:1 ratio to either an intervention group (IPTp delivered by CHWs) or a control group (standard practice, with IPTp delivered at HFs) in three districts of Burkina Faso to assess the effect of IPTp administration by community health workers (CHWs) on the coverage of IPTp and antenatal care (ANC). The districts and facilities were purposively selected taking into account malaria epidemiology, IPTp coverage, and the presence of active CHWs. Pre- and post-intervention surveys were carried out in March 2017 and July–August 2018, respectively. A difference in differences (DiD) analysis was conducted to assess the change in coverage of IPTp and ANC over time, accounting for clustering at the health facility level. Results: Altogether 374 and 360 women were included in the baseline and endline surveys, respectively. At baseline, women received a median of 2.1 doses; by endline, women received a median of 1.8 doses in the control group and 2.8 doses in the intervention group (p-value <.0001). There was a non-statistically significant increase in the proportion of women attending four ANC visits in the intervention compared to control group (DiD= 12.6%, p-value= 0.16). By the endline, administration of IPTp was higher in the intervention than control, with a DiD of 17.6% for IPTp3 (95% confidence interval (CI) -16.3, 51.5; p-value 0.31) and 20.0% for IPTp4 (95% CI -7.2, 47.3; p-value= 0.15). Conclusions: Community delivery of IPTp could potentially lead to a greater number of IPTp doses delivered, with no apparent decrease in ANC coverage.
Dandelion Extract Relaxes Mouse Airway Smooth Muscle by Blocking VDLCC and NSCC Channels
Authors: ping zhao , Liu Jia , Ming Qian , Tian Di , He Jingwen , Yang Ziwei , Shen Jinhua , Liu Qinghua , Yang Xinzhou
Published: July 2020

Background: Asthma is one of the main intractable diseases recognized by the international medical community. The current widely used bronchodilators for asthma—β2-adrenal receptor agonists—have limited therapeutic effects, necessitating the development of novel antiasthma drugs with increased efficacy and fewer adverse effects. In this study, we investigated the relaxant effects and underlying mechanism of an ethyl acetate extract from dandelion (EAED) on mouse airway smooth muscle.Methods: The effects of EAED on agonist-induced precontraction in mouse airway smooth muscle were evaluated with force measurement. Mouse lung slices were used to study the effects of EAED on bronchial smooth muscle. The intracellular Ca2+ concentration was measured using a calcium imaging system. L-type voltage-dependent calcium channel (VDLCC) and non-selective cationic channel (NSCC) currents were measured by patch-clamp. The lung functions of healthy and asthmatic mouse groups were assessed via the forced oscillation technique.Results: EAED inhibits acetylcholine-induced sustained contractions of whole airway smooth muscle by inhibiting VDLCCs, NSCCs, and some unknown channels, reduces the agonist-induced increase in the cytosolic free Ca2+ concentration in airway smooth muscle cells, blocks VDLCC and NSCC currents, and relieves the respiratory resistance of healthy and asthmatic mice.Conclusions: EAED may have potential beneficial effects on asthma attacks.
Immunophenotype of Pediatric NTRK fusion mesenchymal tumors
Authors: Kang Jeongwan , Park Jin Woo , Won Jae-Kyung , Bae Jeong Mo , Koh Jaemoon , Yim Jeemin , Yun Hongseok , Kim Seung-Ki , Choi Jung Yoon , Kang Hyoung Jin , Kim Woo Sun , Shin Joo Heon , Park Sung-Hye
Published: July 2020

Background: While ETV6-NTRK3 fusion is common in infantile fibrosarcoma, NTRK1/3 fusion in pediatric tumors is scarce and, consequently, not well known. Herein, we evaluated NTRK1/3 fusion pediatric mesenchymal tumors clinicopathologically and immunophenotypically. Methods: We reviewed nine NTRK -fusion pediatric sarcomas confirmed by fluorescence in situ hybridization and/or next-generation sequencing from Seoul National University Hospital between 2002 and 2020. Results: One case of TPR - NTRK1 fusion-positive intracranial extra-axial high-grade undifferentiated sarcoma (12-year-old boy), one case of LMNA-NTRK1 fusion-positive low-grade infantile fibrosarcoma of the forehead (3-year-old boy), one case of ETV6-NTRK3 fusion-positive inflammatory myofibroblastic tumor (IMT) (3-months-old girl), and six cases of ETV6-NTRK3 fusion-positive infantile fibrosarcoma (median age: 2.6 months, range: 1.6–5.6 months, M: F = 5:1) were reviewed. The Trk immunopositive pattern was distinctive according to the fusion genes. We notified nuclear positivity in TPR-NTRK1 fusion sarcoma, nuclear membrane positivity in LMNA-NTRK1 fusion sarcoma, and both cytoplasmic and nuclear positivity in ETV6-NTRK3 fusion-positive IMT and infantile fibrosarcomas. Also, the TPR-NTRK1 fusion sarcoma showed robust positivity for CD34/nestin and high mitoses. The LMNA-NTRK1 fusion sarcoma revealed CD34/S100 protein/nestin/CD10 coexpression, and a low mitotic rate. The IMT with ETV6-NTRK3 fusion expressed SMA. Six infantile fibrosarcomas with ETV6-NTRK3 fusion showed variable coexpression of nestin (6/6)/CD10 (4/5)/ S100 protein (3/6). Conclusions: All cases of NTRK1 and NTRK3 fusion-positive pediatric tumors robustly expressed the Trk protein. A Trk immunopositive pattern and CD34/S100/nestin/CD10/SMA immunohistochemical phenotype may suggest NTRK fusion partner genes and diagnoses. LMNA-NTRK1 fusion sarcoma might be a low-grade subtype of infantile fibrosarcoma. Interestingly, more than half of the infantile fibrosarcoma cases were positive for S100 protein and CD10. The follow-up period of TPR-NTRK1 and LMNA-NTRK1 fusion tumors are not enough to predict prognosis. However, ETV6-NTRK3 fusion infantile fibrosarcomas showed an excellent prognosis with no evidence of disease for an average of 11.7 years after gross total resection of the tumor.
The value of the "Surgical Risk Preoperative Assessment System" (SURPAS) in preoperative consultation for elective surgery: a pilot study.
Authors: Bronsert Michael R. , Lambert-Kerzner Anne , Henderson William G. , Hammermeister Karl E. , Atuanya Chisom , Aasen Davis M , Singh Abhinav B. , Meguid Robert A.
Published: July 2020

Background: Risk assessment is essential to informed decision making in surgery. Preoperative use of the Surgical Risk Preoperative Assessment System (SURPAS) providing individualized risk assessment, may enhance informed consent. We assessed patient and provider perceptions of SURPAS as a risk assessment tool.Methods: A convergent mixed-methods study assessed SURPAS’s trial implementation, concurrently collecting quantitative and qualitative data, separately analyzing it, and integrating the results. Patients and providers were surveyed and interviewed on their opinion of how SURPAS impacted the preoperative encounter. Relationships between patient risk and patient and provider assessment of SURPAS were examined.Results: A total of 197 patients were provided their SURPAS postoperative risk estimates in nine surgeon’s clinics. Of the total patients, 98.8% reported they understood their surgical risks very or quite well after exposure to SURPAS; 92.7% reported SURPAS was very helpful or helpful. Providers shared that 83.4% of the time they reported SURPAS was very or somewhat helpful; 44.7% of the time the providers reported it changed their interaction with the patient and this change was beneficial 94.3% of the time. As patient risk increased, providers reported that SURPAS was increasingly helpful (p<0.0001).Conclusions: Patients and providers reported the use of SURPAS helpful and informative during the preoperative risk assessment of patients, thus improving the surgical decision making process. Patients thought that SURPAS was helpful regardless of their risk level, whereas providers thought that SURPAS was more helpful in higher risk patients.
Antimicrobial Resistance and Molecular Detection of Extended Spectrum β-Lactamase Producing Escherichia coli Isolates from Raw Meat in Greater Accra Region, Ghana
Authors: Dsani Esther , Afari Edwin Andrews , Danso-Appiah Anthony , Kenu Ernest , Kaburi Basil Benduri , Egyir Beverly
Published: July 2020

BackgroundTypically, raw meat can be contaminated with antimicrobial resistant pathogens at unhygienic slaughter and sale points. Consumption of meat contaminated with antimicrobial resistant E. coli is associated with grave health care consequences. The aim of this study was to determine the microbial quality of raw meat, the antimicrobial susceptibility and Extended Spectrum Beta Lactamase (ESBL) production in E. coli isolates from raw meat.ResultsTotal Plate Counts exceeded the acceptable limit of 5.0 log CFU/ cm2 in 60.5% (124/205) of raw meat samples. Total Coliform Counts in 70.7% (145/205) of samples were in excess of the acceptable limit of 2.5 log CFU/cm2. E. coli was detected in about half of raw meat samples (48%), ranging from 9.5% -79.0% among the slaughter sites. Isolates were susceptible to meropenem (100%), ceftriaxone (99%), cefotaxime (98%), chloramphenicol (97%), gentamycin (97%), ciprofloxacin (92%) and amikacin (92%), but resistant to ampicillin (57%), tetracycline (45%), sulfamethoxazole-trimethoprim (21%) and cefuroxime (17%). Multi-drug resistance (MDR) was identified in 22% of the isolates. The blaTEM gene was detected in 4% (4/98) of E. coli isolates in this study.ConclusionThe levels of microbial contamination of raw meat in this study were unacceptable. Meat handlers and consumers are at risk of foodborne infections from E. coli including ESBL producing E. coli that are resistant to most antibiotics in use. We recommend an enhanced surveillance for antimicrobial resistance in food products for the early detection of emerging resistant bacteria species in the food chain.
N-acetyl Cysteine Can Blunt Metabolic and Cardiovascular Effects via Down-regulation of Cardiotrophin-1 in Rat Model of Fructose-induced Metabolic Syndrome
Authors: Abdelhaffez Azza salaheldien , El-Aziz Ebtihal Anwar Abd , Tohamy Maha Baghdady , Ahmed Asmaa Mahmoud
Published: July 2020

Background
Chronic fructose consumption is associated with development of obesity, insulin resistance (IR) and metabolic syndrome (MS). Cardiovascular diseases are linked to metabolic deregulation observed in MS. N-acetylcysteine (NAC) is a sulfur containing compound of Allium plants (such as garlic and onion) that increases intracellular reduced glutathione concentrations, which is an endogenous antioxidant.
Methods
This study investigated the ability of N-acetyl cysteine (NAC) to alleviate the metabolic disorders in fructose-induced MS in male Wistar rats and to examine its protective effect on aortic and cardiac tissues via its influence on cardiotrophin-1 (CT-1) expression. NAC (20 mg/kg b.w./day) was administered to fructose (20% w/v) induced MS animals for twelve weeks.
Results
Chronic fructose consumption increased body weight gain, relative heart weight, systolic blood pressure (SBP), diastolic blood pressure (DBP), IR and associated with metabolic alterations. Histological and immunohistochemical examination revealed aortic stiffness and myocardial degeneration and fibrosis together with increased CT-1 expression. Treatment with NAC improved IR, SBP, DBP and mitigated atherogenic dyslipidaemia and oxidative stress (OS). Additionally, NAC down-regulated CT-1 expression in the heart and aorta. Furthermore, CT-1 expression in the heart and aorta was positively correlated with basal glycemia, final SBP and DBP, total cholesterol, triglycerides, low density lipoproteins and negatively correlated with high density lipoproteins levels.
Conclusion
The findings reported here demonstrated, for the first time, the protective effect of NAC against aortic and myocardial degeneration and fibrosis through down-regulation of CT-1 in fructose induced MS animal model. Also, our results revealed the infallible role of NAC to blunt the cardiometabolic deregulation observed in MS.
Involvement of Gastroenterology Fellows in Colonoscopy Improves the Adenoma Detection Rate: A Retrospective Cohort Study
Authors: Kiwan Wissam , Patel Suhag , Judd Stephanie , Nas Hala , Goyal Sachin , Antaki Fadi
Published: July 2020

Background: The quality of colonoscopy is sometimes questioned by the patient, the family and even the endoscopist when a trainee is involved in the procedure. The adenoma detection rate (ADR) has emerged as the main quality measure for colonoscopy due to its inverse correlation with colorectal cancer (CRC) incidence. Few studies have evaluated the impact of involvement of trainees on the quality of colonoscopy, with conflicting results.Aims: We aimed to evaluate the effect of fellow involvement on ADR and polyp detection.Methods: A retrospective chart review was conducted for outpatient colonoscopies (December 2013 to April 2015) done for patients 40-85 years old which were complete and were performed by academic gastroenterologists. Colonoscopies with inadequate bowel preparation were excluded.Results: 1100 patients were included. Indication was screening or surveillance in 60%. Most were males (93%), and 50% were African American. Mean age was 62.1 years. A gastroenterology fellow participated in 54.7% of the procedures.Fellow involvement resulted in a significant increase in the ADR (55.2% to 64.6%, P=0.001). There was also a substantial increase in mean number of polyps (2.59 to 3.27; P < 0.001), adenoma per patient (1.56 to 2.06; P = 0.001) as well as detection of at least three adenomas (21.7% to 29.2%; P = 0.004). Conclusions: Participation of trainees in colonoscopy is associated with a higher ADR and a higher number of polyps per patient, providing reassurance to patients and healthcare providers about the quality of the colonoscopy.
A familial cluster of COVID-19 infection in a northern Chinese region
Authors: Sun Lu-yao , Liu Zhi-hui , Zhang Peng , Chen Hai-ying , Lou Li-xin , Li Xin , Bao Wan-guo , Zhang Kai-yu , Sun Yi-zhe
Published: July 2020

Background

Currently, coronavirus disease 2019 (COVID-19) has spread worldwide and become a global health concern. Here, we report a familial cluster of COVID-19 infection in a northern Chinese region and share our local experience.
Methods

A familial cluster of six patients infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) was included for analysis. The demographic data, clinical features, laboratory examinations, and epidemiological characteristics of enrolled cases were collected and analyzed.
Results

Two family members (Cases 1 and 2) had Hubei exposure history and were admitted to the hospital with a confirmed diagnosis of COVID-19; eight familial members who had contact with them during the incubation period were isolated in a hospital. Finally, the condition of four members (Cases 3, 4, 5, and 6) was as follows. Case 3 had negative SARS-CoV-2 RT-PCR results but was suspected to have COVID-19 because of radiographic abnormalities. Cases 4 and 5 developed COVID-19. Due to positive SARS-CoV-2 RT-PCR results, Case 6 was considered an asymptomatic carrier. In addition, four close contacts did not have evidence of SARS-CoV-2 infection.
Conclusions

Our findings suggest that COVID-19 has infectivity during the incubation period and preventive quarantine is effective for controlling an outbreak of COVID-19 infection.
The Effectiveness of NEPA in the Prevention of Chemotherapy-Induced Nausea Vomiting Among Chemo Naive Patients in an Indian Setting
Authors: Vaswani Bharat Ashok , Dattatreya Palanki Satya , Bhagat Sagar Bhimrao , Patil Saiprasad , Barkate Hanmant
Published: July 2020

Background: Chemotherapy induced nausea- vomiting (CINV) is considered as the most common, feared and most troublesome side effect of chemotherapy. NEPA (NEtupitant 300 mg + PAlonosetron 0.50 mg) is the first commercially available oral fixed-dose combination (FDC) of two active antiemetic agents in India. The present study was planned to evaluate the effectiveness of NEPA in the real world setting of India. Methods: This was a multicentric retrospective study conducted in two centers in India. The data of all chemonaive patients, who were prescribed NEPA was analyzed. Effectiveness i.e. complete response and complete protection in controlling overall, acute and delayed phase was analyzed. Results: A total of 329 patients were enrolled in the study. 260 received highly emetogenic chemotherapy (HEC) regimen and 69 received moderately emetogenic chemotherapy (MEC) regimen. Among all the enrolled patients, complete response in acute, delayed and overall phase was 93 %, 85.71 % and 85.41 % respectively; and completed protection was 88.44 %, 81.76 % and 80.54 % respectively. Those who received HEC regimen, the completed response and complete protection in overall phase was 84.61 % and 79.61 % respectively and those who received MEC regimen the completed response and complete control in overall phase was 84.05 % and 84.05 % respectively. Conclusion: A single oral dose of NEPA targeting dual pathways showed effective control of nausea-vomiting in patients on the HEC and MEC regimens and had good control over nausea-vomiting in acute, delayed and overall phase of nausea-vomiting.
Utilization of Digital Marketing to Improve Sales Volume of MSME's Products
Authors: Nafiuddin Nafiuddin , Hamdan Hamdan
Published: July 2020

Micro, Small, Medium Enterprise (MSME's) marketing is still limited to traditional models and has not yet utilized digital marketing optimally. The purpose of this article is to identify the use of social media to increase the sales volume of MSME's products. This article uses the literature study method, using secondary data. Data analysis techniques used a descriptive approach. The results of studies and analysis show that the importance of using social media such as Collaborative projects (Example: Wikipedia), content communities or sharing media such as YouTube, social networking sites (example: Facebook), and virtual social worlds or market places such as open outlets, Tokopedia, and shopper. Optimizing social media can increase market share and sales of MSME's products.
Competitive Advantages of Sharia Banks: Role of Ihsan Behavior and Digital Marketing in New Normal
Authors: Sodikin Mohamad
Published: July 2020

Covid pandemic 19 had an impact on all aspects, one of which was related to Islamic banking. This article aims to discuss the role of Ihsan's behaviour as a foundation in building relationships with customers, building brand image through communication with the characteristics of Islamic values, and how organizations provide support so that the development of digital marketing communication runs effectively. The method uses a qualitative approach, with secondary data sources. Data analysis uses descriptive analysis approach. The results of the study show that the new pattern of life called the new normal as a result of the co-19 pandemic has affected various sectors of social, economic, and even religious life. Islamic banks, as part of institutions that have an important role must be able to adapt and have a strategy to establish excellent communication and services with their customers. The business foundation, with the foundation of Ihsan values, with communication strategies through digital media, is expected to be able to increase the advantages of Islamic banks.
Social Capital and Resilience School for Disaster Mitigation Education in Yogyakarta Schools
Authors: Dwiningrum Siti Irene Astuti , Prihastuti - , Suwarjo -
Published: July 2020

This study was aimed at determining the usage of social capital to cope with the disaster and school resilience in disaster mitigation education and describing the resilience profiles of the schools in Bantul dan Sleman. The study was qualitative research conducted in high schools located in Sleman and Bantul, Yogyakarta. The subjects were teachers and students. The data were collected using observation, interviews, active participation, FGD, documentation, and questionnaires. The data were analyzed through the stages of data reduction, categorization, interpretation and presentation. Findings show that first, there exists social capital in the form collaboration and social norms between the schools and the society; second, disaster-prone areas need to improve and reform aspects of the school resilience consisting of improvement between the school and the society, establishment of clear rules and consistency in taking them, teaching students life skills, care and support in  realizing and communicating high expectations, and providing opportunities for meaningful participation.MODAL SOSIAL DAN RESILIENSI SEKOLAH UNTUK PENDIDIKAN MITIGASI BENCANA DI SEKOLAH DI YOGYAKARTAPenelitian ini bertujuan untuk mengetahui modal sosial yang digunakan untuk mengatasi bencana dan ketahanan sekolah untuk pendidikan mitigasi bencana dan menggambarkan profil resiliensi sekolah di wilayah Bantul dan Sleman. Penelitian dilakukan di SMA Negeri di wilayah Sleman dan Bantul di, Yogyakarta. Penelitian ini merupakan penelitian kualitatif. Subjek penelitian adalah guru dan siswa. Pengumpulan data dilakukan melalui observasi, wawancara partisipasi aktif, FGD, dokumentasi dan kuesioner. Data dianalisis melalui beberapa tahapan yakni pereduksian data, kategorisasi, interpretasi dan penyajian. Data dikumpulkan melalui wawancara dan observasi. Hasil penelitian menunjukkan pertama, adanya modal sosial berupa kolaborasi dan norma sosial antara sekolah dan masyarakat; kedua, sekolah di daerah rawan bencana perlu meningkatkan dan reformasi aspek ketahanan sekolah terdiri atas aspek dalam meningkatkan antara sekolah masyarakat, aspek dalam membangun aturan yang jelas dan menjalankan secara konsisten, aspek dalam mengajar keterampilan hidup bagi siswa, peduli dan mendukung aspek dalam mewujudkan harapan dan berkomunikasi diajarkan, dan aspek dalam memberikan kesempatan untuk berpartisipasi.
STUDENTS’ PEACEFUL MENTALITY AND PESANTREN-BASED SCHOOL RULES
Authors: Hidayat Ade , Ilfiandra Ilfiandra , Kartadinata Sunaryo
Published: July 2020

This study was aimed at eliciting facts of peaceful conditions experienced by students in the environment of Pesantren-based schools, positively and negatively, and revealing the students’ mentality in the face of the school rules. The study was done in Madrasah Aliyah (Mualimin) Pesantren Persatuan Islam (PPI) 76 Tarogong, Garut. The study used the narrative method based on the data collected by questionnaires, interviews, observation, and literature study using interactive analyses. Findings show that the synergy of school rules, curriculum contents, teachers, facilities and infrastructures, and other internal elements of the pesantren-based school actualized a unified peaceful life atmosphere which is significant for students, individually or communally. The spiritual and religious foundation of the education has a solid structure in building pillars of peacefulness within the students. Internalization of awareness towards human roles and duties and life guidelines taught by Islamic teaching scaffolds the formation of the strong harmony between students’ attitudes and school rules, preventing students from discipline mentality that is weak and superficialMENTALITAS DAMAI SISWA DAN PERATURAN SEKOLAH BERBASIS PESANTRENPenelitian ini bertujuan untuk menggali fakta-fakta kondisi damai yang dialami para siswa dalam lingkungan sekolah berbasis pesantren, baik positif maupun negatif dan mengungkapkan mentalitas mereka dihadapkan dengan peraturan sekolah. Penelitian dilakukan di Madrasah Aliyah (Mualimin) Pesantren Persatuan Islam (PPI) 76 Tarogong Garut. Metode yang digunakan adalah metode naratif berdasarkan data-data yang dikumpulkan dengan teknik kuesioner, wawancara, dan studi literatur yang menggunakan analisis interaktif. Hasil penelitian menunjukkan bahwa sinergitas peraturan sekolah, muatan kurikulum, para pendidik, sarana dan prasarana, serta elemen internal lain dari sekolah berbasis pesantren tersebut membangun satu keutuhan kondisi atmosfer kehidupan sarat damai yang cukup signifikan bagi para siswa, baik individual maupun komunal. Fondasi spiritual dan keagamaan dalam pendidikan memiliki struktur yang kokoh dalam menyusun pilar kedamaian dalam diri siswa. Internalisasi kesadaran fungsi dan tugas manusia serta pedoman berkehidupan yang diajarkan agama (Islam) sangat menopang terbentuknya harmoni sikap siswa terhadap peraturan sekolah yang kokoh, yaitu terhindar dari mental disiplin yang rapuh dan ragawi semata
SELF-EVALUATION ON THE LEARNING STRATEGIES OF THE GRADUATE STUDENTS OF INDONESIAN LANGUAGE EDUCATION STUDY PROGRAM
Authors: Syamsi Kastam , Setiawan Teguh , Suryaman Maman
Published: July 2020

EVALUASI DIRI STRATEGI BELAJAR MAHASISWAPROGRAM STUDI MAGISTER PENDIDIKAN BAHASA INDONESIAAbstrakPenelitian ini bertujuan untuk mendeskripsikan hasil evaluasi diri strategi belajar mahasiswa. Subjek penelitian ini adalah mahasiswa Program Studi Magister Pendidikan Bahasa Indonesia Program Pascasarjana Universitas Negeri Yogyakarta. Data dikumpulkan melalui instrumen angket evaluasi diri dengan skala likert. Teknik analisis data yang digunakan adalah analisis deskriptif kuantitatif. Hasil penelitian ini adalah sebagai berikut. Pertama, sebelum perkuliahan, sebagian besar mahasiswa memperhatikan silabus, mencari referensi, dan melaksanakan tugas. Tetapi, sebagian besar mahasiswa jarang membaca referensi dan menyiapkan pertanyaan. Kedua, selama perkuliahan, semua mahasiswa memperhatikan, mendiskusikan, dan melaksanakan tugas perkuliahan. Tetapi, sebagian besar mahasiswa jarang mencatat dan mengajukan pertanyaan. Ketiga, setelah perkuliahan semua mahasiswa mengerjakan tugas. Tetapi, sebagian besar mahasiswa jarang mendiskusikan perkuliahan, membaca berbagai referensi dan mencari artikel jurnal internasional. Sehubungan dengan itu, untuk memperoleh hasil belajar yang baik, pengelola Program Studi Pendidikan Bahasa Indonesia Program Pascasarjana Universitas Negeri Yogyakarta perlu memiliki manajemen yang baik dan mengimplementasikan strategi pembelajaran yang tepat, yakni strategi pemutakhiran metode pembelajaran sesuai kebutuhan pasar dan perkembangan jaman.Kata kunci: evaluasi diri, strategi belajar, perkuliahanAbstractThis study was aimed at describing the results of students’ self-evaluationon their learning strategies. The subjects of the studywere all graduatestudents of the Indonesian Language Education Program at Yogyakarta State University. The data were collected using a questionnaire of self-evaluation using the Likert scale. The data were analyzed through quantitative descriptive techniques. The results show the following. First, before class, most students focus only on the syllabus, search references, and perform tasks. However, most students rarely read references and prepare questions. Secondly, during class, all students pay attention, do discussions, and carry out lecture duties. However, most students rarely take notes and ask questions. Third, after class, all students do the assignments. However, most students rarely discuss lectures, read references and search for international journal articles. In order to obtain a good learning result, the personnel of the Indonesian Education Study Program need to apply good management and implement the right learning strategies in updating the learning method according to market needs and the development of the era.Keywords: self-evaluation, learning strategy, lecture activity
COGNITIVE MORAL APPROACH TO CIVICS EDUCATION MATERIAL DEVELOPMENT IN THE ELEMENTARY SCHOOL
Authors: Prihandoko Yogi , Slamet St. Y. , Winarno Winarno
Published: July 2020

PENDEKATAN COGNITIVE MORAL SEBAGAI KERANGKA PENGEMBANGAN BAHAN AJAR PPKN DI SEKOLAH DASARAbstrakPenelitian ini bertujuan untuk mendeskripsikan implementasi pembelajaran PPKn sebagai wahana pendidikan moral dan relevansi pendekatan cognitive moral sebagai kerangka pengembangan bahan ajar PPKn untuk membelajarkan nilai-nilai moral. Penelitian ini adalah deskriptif analitis dengan menggunakan pendekatan kualitatif. Subjek penelitian adalah 122 siswa kelas V sekolah dasar dan 4 guru pengampu Mata Pelajaran PPKn pada empat kecamatan di Kota Salatiga. Teknik pengumpulan data dalam penelitian ini menggunakan observasi, angket, wawancara, dan studi dokumen. Temuan hasil penelitian dianalisis menggunakan analisis interaktif model Miles dan Huberman kemudian disajikan melalui teks narasi deskriptif. Hasil penelitian menunjukkan bahwa pertama, proses pelaksanaan pembelajaran PPKn belum merepresentasikan pendidikan moral. Kedua, guru tidak melaksanakan pembelajaran moral yang terencana dan sistematis dalam pembelajaran PPKn. Ketiga, pengetahuan siswa tentang moral rendah. Keempat, siswa mengalami miskonsepsi terhadap substansi dan tujuan PPKn. Kelima, muatan PPKn pada buku tematik Kurikulum 2013 tidak menguraikan materi tentang moral. Keenam, pendekatan cognitive moral melalui cerita dilema relevan sebagai solusi pengembangan bahan ajar PPKn untuk membelajarkan moral di sekolah dasar. Kata kunci: cognitive moral, PPKn, sekolah dasarAbstractThe study was aimed at describing the implementation of the civics education subject as a means of moral education and the relevance of cognitive moral approach as a framework for developingcivics education instructional materials. The study was descriptive analytical research using a qualitative approach. The subjects of the study were 122 fourth-grade students of elementary school and 4 teachers of civics education in four districts in Salatiga City. The data collection techniques were observation, questionnaires, interviews, and documents. The data were analyzed using interactive analysis of Miles and Huberman model and presented through descriptive narrative texts. The results show that first, civic education learning has not yet represented moral education. Second, teachers do not carry out planned and systematic moral learning in civics education learning. Third, students’ moral comprehension is still low. Fourth, students have misconceptions about the substance and the purpose of civics educationlearning. Fifth, the content of civics education in the thematic book of Curriculum 2013 does not include the material related to moral learning. Sixth, the cognitive moral approach through the dilemma story is relevant as a solution for the development of civics education instructional materials to teach morals in the elementary school.Keywords:cognitive moral, civic education, elementary school education
AUDIO-VIDEO BASED READING LEARNING MODEL FOR MENTALLY- RETARDED STUDENTS
Authors: Dharmawan Alexander , Wahyuni Ana
Published: July 2020

MODEL PEMBELAJARAN MEMBACA BERBASIS AUDIO-VIDEO UNTUK SISWA TUNAGRAHITAAbstrakPenelitian ini bertujuan untuk membangun model pembelajaran membaca untuk siswa SDLB C (tunagrahita) dan menerapkan model tersebut pada siswa dengan media (software) yang telah dibuat. Metode yang digunakan adalah Research and Development dengan tahap prapengembangan, pengembangan, penerapan model, dan revisi serta pengembangan model. Model pembelajaran dibangun berdasarkan penelusuran pustaka, konsultasi dengan psikolog klinis anak berkebutuhan khusus dan wawancara dengan guru SDLB. Penelitian dilakukan sampai pada tahap penerapan model. Penerapan model dilakukan dengan menggunakan media software pembelajaran berbasis audio-video. Subjek penelitian adalah siswa di 6 SDLB kelas 3 sampai 4 dengan indikasi tunagrahita ringan (hasil tes IQ 50-75) yang belum bisa/belum lancar membaca. Kegiatan ini dilakukan dengan metode eksperimen, yaitu melakukan pretest, treatment dengan model pembelajaran yang telah dikembangkan, dan posttest. Hasil penelitian menunjukkan bahwa pertama, model pembelajaran membaca berbasis auido-video dapat menunjang pembelajaran membaca pada pendidikan luar biasa tingkat dasar. Kedua, nilai pretest, posttest, dan uji statistik lain menunjukan bahwa model pembelajaran membaca berbasis audio-video sangat signifikan untuk meningkatkan kemampuan membaca anak tunagrahita.Kata kunci: audio-video, pembelajaran membaca, tunagrahitaAbstractThis study was aimed at generating a reading learning model for metally-retarded students in inclusive elementary schools and applying the model using the software that was developed. The study used the Research and Development method with pre-development, development, model implementation, revision, and model development. The learning model was generated from literature review, consultation with clinical psychologists, and interviews with the inclusive school teachers. The application of the model was done by using audio-video based learning media (software). The subjects of this study were the third and fourth grade students in 6 inclusive schools with an indication of mental retardation (IQ test score 50-75) who had not/could not read fluently. The activities were done in an experimental technique consistsing of pretest, treatment with the developed model, and posttest. The results show that first, the model of learning can be one of the solutions that support the learning of reading for the extraordinary level of basic education. Second, the results of pretest, posttest, and statistical test show that the model significantly improve the reading ability of the mental-retarded students.Keywords: audio-video learning media, learningof reading, mental retardation