bluuebunny/crossref_metadata_2025 huggingface dataset:
New Look on Antifungal Activity of Silver Nanoparticles (AgNPs)
Authors: ŻAROWSKA BARBARA , KOŹLECKI TOMASZ , PIEGZA MICHAŁ , JAROS-KOŹLECKA KATARZYNA , ROBAK MAŁGORZATA
Published: December 2019

The progress of research on silver nanoparticles (AgNPs) has led to their inclusion in many consumer products (chemicals, cosmetics, clothing, water filters, and medical devices) as a biocide. Despite the widespread use of AgNPs, their biocidal activity is not yet fully understood and is usually associated with various factors (size, composition, surface, red-ox potential, and concentration) and, obviously, specific features of microorganisms. There are merely a few studies concerning the interaction of molds with AgNPs. Therefore, the determination of the minimal AgNPs concentration required for effective growth suppression of five fungal species (Paecilomyces variotii, Penicillium pinophilum, Chaetomium globosum, Trichoderma virens, and Aspergillus brasiliensis), involved in the deterioration of construction materials, was particularly important. Inhibition of bacteria (Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli) and yeasts (Candida albicans and Yarrowia lipolytica) was also assessed as the control of AgNPs effectiveness. AgNPs at the concentrations of 9–10.7 ppm displayed high inhibitory activity against moulds, yeast, and bacteria. The TEM images revealed that 20 nm AgNPs migrated into bacterial, yeast, and fungal cells but aggregated in larger particles (50–100 nm) exclusively inside eukaryotic cells. The aggregation of 20 nm AgNPs and particularly their accumulation in the cell wall, observed for A. brasiliensis cells, are described here for the first time.
Differentially Marked IncP-1β R751 Plasmids for Cloning via Recombineering and Conjugation
Authors: BAINS ASHVEEN , WILSON JAMES W.
Published: December 2019

We demonstrate here for the first time the use of an IncP-1β plasmid, R751, as a gene capture vehicle for recombineering/conjugation strategies to clone large segments of bacterial genomes (20 – 100 + Kb). We designed R751 derivatives containing alternative markers for greater flexibility when using the R751 vehicle across different bacteria. These markers are removable if desired as part of the cloning procedure (with no extra steps needed). We demonstrated utility via cloning of 38 and 22 kb genomic segments from Salmonella enterica serovar Typhimurium and Escherichia coli, respectively. The plasmids expand the options available for use in recombineering/conjugation-based cloning applications.
Illumina MiSeq Analysis and Comparison of Freshwater Microalgal Communities on Ulleungdo and Dokdo Islands
Authors: YUN HYUN-SIK , KIM YOUNG-SAENG , YOON HO-SUNG
Published: December 2019

Ulleungdo and Dokdo are volcanic islands with an oceanic climate located off the eastern coast of South Korea. In the present study, we used barcoded Illumina MiSeq to analyze eukaryotic microalgal genera collected from Seonginbong, the highest peak on Ulleungdo, and from groundwater sites on Dongdo and Seodo Islands, which are part of Dokdo. Species richness was significantly greater in the Seonginbong samples than in the Dongdo and Seodo samples, with 834 operational taxonomic units (OTUs) identified from Seonginbong compared with 203 OTUs and 182 OTUs from Dongdo and Seodo, respectively. Taxonomic composition analysis was also used to identify the dominant microalgal phyla at each of the three sites, with Chlorophyta (green algae) the most abundant phyla on Seonginbong and Dongdo, and Bacillariophyta (diatoms) the most abundant on Seodo. These findings suggest that differences in the abundances of Chlorophyta and Bacillariophyta species in the Seonginbong, Dongdo, and Seodo samples are due to variations in species richness and freshwater resources at each sampling location. To the best of our knowledge, this is the first report to detail freshwater microalgal communities on Ulleungdo and Dokdo. As such, the number of species identified in the Seonginbong, Dongdo, and Seodo samples might be an indicator of the ecological differences among these sites and varying characteristics of their microbial communities. Information regarding the microalgal communities also provides a basis for understanding the ecological interactions between microalgae species and other eukaryotic microorganisms.
Colistin Resistance in Enterobacterales Strains – A Current View
Authors: STEFANIUK ELŻBIETA M. , TYSKI STEFAN
Published: December 2019

Colistin is a member of cationic polypeptide antibiotics known as polymyxins. It is widely used in animal husbandry, plant cultivation, animal and human medicine and is increasingly used as one of the last available treatment options for patients with severe infections with carbapenem-resistant Gram-negative bacilli. Due to the increased use of colistin in treating infections caused by multidrug-resistant (MDR) bacteria, the resistance to this antibiotic ought to be monitored. Bacterial resistance to colistin may be encoded on transposable genetic elements (e.g. plasmids with the mcr genes). Thus far, nine variants of the mcr gene, mcr-1 – mcr-9, have been identified. Chromosomal resistance to colistin is associated with the modification of lipopolysaccharide (LPS). Various methods, from classical microbiology to molecular biology methods, are used to detect the colistin-resistant bacterial strains and to identify resistance mechanisms. The broth dilution method is recommended for susceptibility testing of bacteria to colistin.
Epidemiology, Drug Resistance, and Virulence of Staphylococcus aureus Isolated from Ocular Infections in Polish Patients
Authors: KŁOS MARTA , POMORSKA-WESOŁOWSKA MONIKA , ROMANISZYN DOROTA , CHMIELARCZYK AGNIESZKA , WÓJKOWSKA-MACH JADWIGA
Published: December 2019

Analysis of the epidemiology of Staphylococcus aureus (SA) ocular infections and virulence factors of the isolates with a special emphasis on their drug resistance, and the ability of biofilm formation. In a period from 2009 to 2013, 83 isolates of SA were prospectively collected and preserved in a multicenter laboratory-based study carried out in southern Poland. Epidemiological, phenotypic, and genotypic analyses were performed. The resistance and virulence genes were analyzed. Screening for the biofilm formation was provided. Among the materials derived from ocular infections from 456 patients, SA was found in 18.2% (n = 83) of cases (one SA isolate per one patient). Most infections were identified in the age group of over 65 years (OR 8.4 95%CI; 1.03-68.49). The majority of patients (73.4%) were hospitalized. Among the virulence and resistance genes, the most frequently detected were the lukE (72.2%, n = 60) and ermA (15.6%, n = 13) genes. A positive result of the CRA test (the ability of biofilm formation) was found in 66.2% (n = 55) of isolates. Among the strains under study, 6.0% (n = 5) had the methicillin-resistant Staphylococcus aureus phenotype, and 26.5% (n = 22) had the macrolide-lincosamide-streptogramin B phenotype. In 48 (57.8%) isolates the neomycin resistance was revealed. All isolates under study were sensitive to vancomycin. The population most susceptible to ocular SA infections consists of hospitalized patients aged 65 and more. The SA strains under study showed the increased ability to biofilm formation. In the strains tested, high susceptibility to chloramphenicol and fluoroquinolones was demonstrated. However, the high level of drug resistance to neomycin detected in this study among SA isolates and the blood-ocular barrier makes it difficult to treat ocular infections.
Structural Changes of Bacillus subtilis Biomass on Biosorption of Iron (II) from Aqueous Solutions: Isotherm and Kinetic Studies
Authors: KRISHNA KANAMARLAPUDI SRI LAKSHMI RAMYA , MUDDADA SUDHAMANI
Published: December 2019

Various microbial biomasses have been employed as biosorbents. Bacterial biomass has added advantages because of easy in production at a low cost. The study investigated the biosorption of iron from aqueous solutions by Bacillus subtilis. An optimum biosorption capacity of 7.25 mg of the metal per gram of the biosorbent was obtained by the Inductive Coupled Plasma Optical Emission Spectroscopy (ICP-OES) under the experimental conditions of initial metal concentration of 100 mg/l, pH 4.5, and biomass dose of 1 g/l at 30°C for 24 hrs. The data showed the best fit with the Freundlich isotherm model while following pseudo-first-order kinetics. Scanning Electron Microscope (SEM) and Energy Dispersive X-ray (EDX) analysis confirmed iron biosorption as precipitates on the bacterial surface, and as a peak in the EDX spectrum. The functional hydroxyl, carboxyl, and amino groups that are involved in biosorption were revealed by the Fourier Transform Infrared spectroscopy (FTIR). The amorphous nature of the biosorbent for biosorption was indicated by the X-ray Diffraction (XRD) analysis. The biomass of B. subtilis exhibited a point zero charge (pHpzc) at 2.0.
Dining Philosophers, Byzantine Generals, and the Various Nodes, Users, and Citizens under Blockchain Rule
Authors: Kera Denisa Reshef
Published: December 2019

Agreements, consensuses, protocols, resource-sharing, and fairness are all examples of social and political metaphors that define and shape new computational algorithms. The thought experiments and allegories about resource-sharing or agreement between nodes played a vital role in the development of "concurrent programming" (enabling processor power-sharing and process synchronization) and still later in the development of distributed computing (facilitating data access and synchronization). These paved the way for current concepts of consensus mechanisms, smart contracts, and other descriptions of cryptocurrencies, blockchain, distributed ledger, and hashgraph technologies, paradoxically reversing the relations between metaphor and artifact. New computing concepts and algorithmic processes, such as consensus mechanisms, trustless networks, and automated smart contracts or DAOs (Distributed Autonomous Organizations), aim to disrupt social contracts and political decision-making and replace economic, social, and political institutions (e.g., law, money, voting). Rather than something that needs a metaphor, algorithms are becoming the metaphor of good governance. Current fantasies of algorithmic governance exemplify this reversal of the role played by metaphors: they reduce all concepts of governance to automation and curtail opportunities for defining new computing challenges inspired by the original allegories, thought experiments, and metaphors. Especially now, when we are still learning how best to govern the transgressions and excesses of emerging distributed ledger technologies, productive relations between software and allegory, algorithms and metaphors, code and law are possible so long as they remain transitive. Against this tyranny of algorithms and technologies as metaphors and aspirational models of governance, we propose sandboxes and environments that allow stakeholders to combine prototyping with deliberation, algorithms with metaphors, codes with regulations.
Blockchain Technology in IoT Systems: Review of the Challenges
Authors: Mezquita Yeray , Casado Roberto , Gonzalez-Briones Alfonso , Prieto Javier , Corchado Juan Manuel
Published: December 2019

Internet of Things (IoT) platforms have a great number of vulnerabilities which cyber-attackers can exploit. A possible solution largely contemplated in the state of the art is to make use of blockchain technology in any IoT system to enhance the security of the platform while improving other of its aspects. Although there are valuable benefits of the use of IoT platforms based on blockchain technology, it is worth studying the different alternatives between blockchain technologies, because all of them have their own limitations that are not suitable for every use case scenario. In this work, we listed a number of flaws that blockchain technology has in this respect. We have identified that, most of the flaws can be overcome by adapting the variants of this technology to the specific needs of the IoT platform. Every IoT system based on blockchain technology, should perform a systematic analysis of their needs, identifying what are the blockchain features sought for that scenario, to choose the solution that best meets the needs among the different blockchain technology alternatives.
Two-tier Blockchain Timestamped Notarization with Incremental Security
Authors: Meneghetti Alessio , Quintavalle Armanda O. , Sala Massimiliano , Tomasi Alessandro
Published: December 2019

Digital notarization is one of the most promising services offered by modern blockchain-based solutions. We present a digital notary design with incremental security and cost reduced with respect to current solutions. A client of the service receives evidence in three steps. In the first step, evidence is received almost immediately, but a lot of trust is required. In the second step, less trust is required, but evidence is received seconds later. Finally, in the third step evidence is received within minutes via a public blockchain.
Privacy Laws in the Blockchain Environment
Authors: Cruz Rocio de la
Published: December 2019

The compatibility between emerging technology such as Blockchain and the new data protection obligations has been a matter of discussion since the European General Data Protection Regulation (“GDPR”) came into force back in 2018. The main reason is that GDPR is considered the Regulation that has incorporated the strongest obligations and enforcement consequences. There are some areas of tension on how to comply with these obligations, some of which are still a matter of discussion that have not been concluded by regulators or in court. In this chapter, I set out an overview of the main obligations, relevant areas of tension and set out an opinion on what I have seen that in practice is working the best, and how I recommend dealing with these issues in practice, in order to do an assessment applied to a particular context in which a Blockchain network is used.
Ecological Study of Different Communities Site from District Lower Dir Laram Timargara Khyber Pakhtun Khwa Pakistan
Authors: ULLAH INAM
Published: December 2019

In the present research work the ecological community study was carried out of District Lower Dir Laram Timargara Khyber Pakhtun Khwa Pakistan. Salvia-Cynodon-Berberiscommunity (SCB). This community comprises a total of 24 plants species. Among these 16 are herbaceous plants, 8 are shrubby plants, while there is no single tree species found in this community. The community is dominated by Salvia moocruftianaWall, Cynodon dactylonand Berberis lyceum. The Species richness (S.R) is 1.31055873, similarity index (S.I) is 33.33333 and its Maturity index (M.I) is 49.Verbascum-Buddleja-Cotoneastercommunity (VBC).This community comprises a total of 23 plants species. Among these 10 are herbaceous, 8 are shrubby plants, while the remaining 5 plants are tree species. The community is dominated by Verbascum thapsus, Buddleja crispa and Cotoneaster nummularia.Species richness (S.R) of the community is 1.499237, similarity index (S.I) is 30.188679while its Maturity index (M.I) is 46.Cyperus-Calotropis-Ziziphuscommunity (CCZ).This community comprises a total of 32 plants species. Among these 20 are herbaceous, 8 are shrubby plants, while the remaining 5 plants are tree species. The community is dominated by Cypres rotundus, Calotropis procera and Cotoneaster nummularia. The Spcies richness (S.R) of the community is 1.146771, similarity index (SI) is 24.39024 and its Maturity index (M.I) is 58.3783. The aim of the present study to explore the flora of Laram Timargara Mountains.
Ethno veterinary Plants Practices at Maidan Valley, lower Dir, Western Himalaya, Pakistan
Authors: HAQ ZAHOOR UL
Published: December 2019

The present study was carried out in order to document the indigenous ethno veterinary knowledge (EVK) practiced by inhabitants of Maidan valley. The localities were named as Manyal, Kumber and Kotkay. All the information were collected regarding Botanicalnames, local names, part used, methods of preparation, dosage and uses. Thirty species (30) species of twenty four (24) families 29 genera of herbs, shrubs and trees were listed. Apiaceae, Brassicaceae, Euphorbiaceae, Lamiaceae, Papilionaceae and Poaceae with two (2) species Acanthaceae, Asclepiadiaceae, Asteraceae, Berberidaceae, Cucurbitaceae, Moraceae, Meliaceae, Mimosaceae, Myrtaceae, Oleaceae, Papaveraceae, Paeoniaceae, Pinaceae, Piperaceae, Sapindaceae, Solanaceae, Violaceae and Zygophylaceae with one(1) species each. Forty seven (47) diseases are cured by these thirty (30) species i.e. Abdominal pain, anesthetic, anti-heat, body temperature, cough, flu, fever, heat cycle, mucus problem, worms and wounds. It has been noted that cough is cured by five (5) species, constipation and digestion by three (3) species, flu by two (2) species, acne, antispasmodic, anti-pain, anesthetic, anti-heat, body pain, bacterial diseases, fever, purgative, gastric trouble, heat cycle, healing wounds, injury, intestinal activeness, indigestion, intestinal worms, infection, increase milk, intestinal pain, muscle nasal problem, power, pneumonia, stomach problem, stomach irritation, tick problem, throat problem, viral diseases, worms and wounds by one (1) species each. Calotropis procerais used for indigestion, intestinal worms and infections and Acacia modestais used for mucus membrane irritation, stomach irritation and digestion. The present study documented missing literature regarding ethno veterinary knowledge which was not previously mentioned.
Floristic list and their ecological characteristics, of plants at village Derikot Selai Pattay district Malakand Khyber Pakhtunkhwa Pakistan
Authors: ISHAQ MUHAMMAD
Published: December 2019

Floristic composition and characteristics studies were made in of vallag Derikot selai pattay District Malakand Khyber Pakhtunkhwa, Pakistan.The floristic composition of present study comprised of 146 species and 41 genera which belong to 39 families. It included 115 dicots species, Monocot 24, Gymnosperm 2, Pteridophytes 5, species. Family Asteraceae (23 spp.)is dominant family in floristic table. In the present study, therophytes with 57 species (39.041%.) were the dominant life form in the study area. Nanophanerophytes with 22 species (15.06%). Microphanerophytes with 22 species (15.06 %). Hemicryptophytes with 19 species (13. 01%). Chamaephytes with 15 species (10. 27%). Geophytes with 5 specie (3.42%). and Megaphanerophytes with 2 species (1.36%) Mesophanerophytes with 4 species (2.73%) were least observed life forms. Leaf size spectra was dominant by microphylls with 61 species (41.78%) followed by mesophylls with 35 species (23.97%), Nanophylls with 26 species (17.80%),Leptophylls with 17 species (11.64%), Aphyllous with 4 species (2.73%).Megaphylls 2 species (1.36%).Macrophyll only 1species (0.66 %) of study area.
Cardiac function profiling and its antidiabetic effect of Daphne mucronata in alloxan induced diabetic rabbits
Authors: ALI BASIT
Published: December 2019

Diabetes mellitusis a chronic hyperglycemia associated with elevated plasma cholesterol.Natural and traditional herbal remedies are a source of new commercial products. Anti-diabetic potential of D. mucronata extracts (methanol) has been assessed in alloxan monohydrate diabetic induced rabbits.The extracts were given orally by 8 hours. Thedose rate was 12 mg, 125mg, 225 mg and 325mg/kg body weight respectively.At every 2 hours blood sample was collected, serum separated and glucose level was determined by kit method. The result suggests that the treatment of 325 mg/kg body weight significantly(p<0.05) decreased blood glucose and cholesterol level at 143 mg/dl and 166.33 mg/dl in the experimental group.Therefore, it is concluded that the D. mucronata possess significant anti-diabetic activity.
Study of blood glucose and SGPT lowering effects of Daphne Mucronata Royle in induced diabetic rabbits
Authors: ULLAH AZIZ
Published: December 2019

This study was carried out to study Anti-diabetic effect of the plant Daphne mucronataextract in alloxan induced diabetic rabbits. To the first fifteen healthy rabbits taken and divided them into five groups as each group contains three numbers of rabbits. Group one kept in normal condition means no induction or treatment observed. Group second was given the diabetic control dose in quantity (12mg/kg). Group three also treated with the dose rate (125mg/kg) the D. Mucronata(methanol) extract. Similarly group no four was treat with the subject extract in the concentration of (225mg/kg). And the last fifth group of rabbits had the dosage of extract (325mg/kg). This mechanism of entrance was orally ingestion and the treatment duration was eight hours, after each of the next two hours from the start the blood samples were collected, serum separated and the glucose level determined by the method known by Kit method. After all the observations we reached to an impressive conclusion that the D. Mucronata(methanol) extract has significant potential to reduce blood glucose level and also recognized to be effective to reduce the blood SGPT enzyme level, so it can be suggested that this plant has such antidiabetic and SGPT reduction effect.
Hypoglycemic and Hypocholestrolemic study of Monothica boxifolia Falc. in induced diabetic Rabbits
Authors: SHIHENG TAO
Published: December 2019

In the present examination, antidiabetic capability of Monothica separates (methanol) has been assessed in alloxan-prompted diabetic hares. Fifteen solid, bunnies were separated into four unique gatherings including, Normal control, Diabetic control , treated with Monothicamethanol remove, with 3 hares in each gathering. The concentrates were given orally for 24 hours, 100 mg, 200 mg, 300 mg extricate per bunny every day. At regular intervals blood test was gathered, serum isolated and absolute glucose level, cholesterol level was controlled by unit strategy. The body weight was recorded on like clockwork interim. The Monothecamethanol extricates lowered blood glucose and cholesterol level demonstrated greatest decrease adequately. The treatment with theseconcentrates additionally diminished the blood glucose and cholesterol. Along these lines, it is presumed that the Monothecapossessnoteworthy antidiabetic movement.
Optimize Elasticity in Cloud Computing using Container Based Virtualization
Authors: Shahzad Muhammad Amir , Aslam Muhammad Sohaib , Sajjad Waseem , Imran Muhammad
Published: December 2019

Cloud computing emphasis on using and underlying infrastructure in a much efficient way. That’s why it is gaining immense importance in today’s industry. Like every other field, cloud computing also has some key feature for estimating the standard of working of every cloud provider. Elasticity is one of these key features. The term elasticity in cloud computing is directly related to response time (a server takes towards user request during resource providing and de-providing. With increase in demand and a huge shift of industry towards cloud, the problem of handling user requests also arisen. For a long time, the concept of virtualization held industry with all its merits and demerits to handle multiple requests over cloud. Biggest disadvantage of virtualization shown heavy load on underlying kernel or server but from past some decades an alternative technology emerges and get popular in a short time due to great efficiency known as containerization. In this paper we will discuss about elasticity in cloud, working of containers to see how it can help to improve elasticity in cloud for this will using some tools for analyzing two technologies i.e. virtualization and containerization. We will observe whether containers show less response time than virtual machine. If yes that’s mean elasticity can be improved in cloud on larger scale which may improve cloud efficiency to a large extent and will make cloud more eye catching.
Study of the Pyrus L. Species of Growth and Development in the ex situ Conditions of the Northeast of the Great Caucasus
Authors: Abbasova S.
Published: December 2019

The article investigated the peculiarities of growth and development of Pyrus L. species in the northeastern part of the Greater Caucasus (Azerbaijan). The study found that there were no significant differences in cultural conditions compared to the natural conditions of the species involved in the study material. The study of the bioecological features of tree plants in Azerbaijan, both natural and cultural, is of great scientific and practical importance.
Brain, Eyes, Light: Biological Electrical Magnetism of Light and Neurorehabilitation of Cognitive Impairment
Authors: Pyatin V. , Romanchuk N. , Romanchuk P. , Volobuev A.
Published: December 2019

Biological electrical magnetism of light and neural networks of the brain is the adaptation and optimization of external and internal lighting conditions (type, nature, duration) to improve the cognitive brain. Homo sapiens brain operates in a 24-hour biological electrical magnetic environment. Light is the strongest synchronizing signal for the circadian system, and therefore keeps most biological and psychological rhythms internally synchronized, which is important for the optimal functioning of H. sapiens brain. Circadian Sleep–Wake disorders and chronic circadian misalignment, often seen in psychiatric and neurodegenerative diseases, may be effective in neurorehabilitation of cognitive impairment. Beneficial effects on circadian synchronization, sleep quality, mood and cognitive performance-depend on the time, intensity and spectral composition of light exposure. Multidisciplinary and multimodal interaction in the triad “brain–eyes–vessels” allows to identify early biomarkers of both General accelerated and pathological aging, and timely diagnose neurodegeneration, and conduct effective neurorehabilitation of cognitive disorders. Control and treatment of vascular risk factors and endocrine disorders can reduce the prevalence of long-term disability among the elderly population. Combined and hybrid methods of neuroimaging in conjunction with artificial intelligence technologies, allow to understand and diagnose neurological disorders and find new methods of neurorehabilitation and medical and social support that will lead to improved mental health. To restore circadian neuroplasticity of the brain, a multimodal scheme is proposed: circadian glasses, functional nutrition and physical activity. A combined and hybrid cluster in the diagnosis, treatment, prevention and rehabilitation of cognitive disorders and cognitive disorders has been developed and implemented.
Treatment of Injuries of the Lumbar Spine
Authors: Sabyraliev M.
Published: December 2019

Surgical treatment of patients with spinal injuries, accompanied by traumatic stenosis of the spinal canal, is an urgent and discussed problem of modern vertebrology. Surgical treatment of 111 patients with various injuries of the thoracolumbar spine was performed. In 40 patients, post-traumatic stenosis was eliminated using ligamentotaxis using transpedicular osteosynthesis. The immediate results of treatment were followed up in all patients: good results were obtained in 33 (82.5%) cases; satisfactory — in 6 (15.0%), unsatisfactory — in 1 (2.5%). Long-term results with a follow-up of more than 1 year were followed up in 27 (67.5%) patients; good results were obtained in 20 (74.0%), satisfactory in 7 (25.0%).
Trends in the Prevalence of Breast Cancer in the Kyrgyz Republic
Authors: Ibraimova A. , Nasirova N. , Bolbachan K.
Published: December 2019

Currently, malignant neoplasms are one of the leading causes of mortality not only in the world, but also in the Kyrgyz Republic. By 2030, the number of new cancer cases is projected to increase to 26.4 million per year and the number of deaths to 17 million. In assessing cancer incidence and mortality from 25 major cancers in 40 countries in Europe, breast cancer was one of the most common causes of cancer death. Statistical data from the Electronic Health Centre and the National Oncology and Hematology Centre of the Ministry of Health of the Kyrgyz Republic were analyzed. In the Kyrgyz Republic, there is a positive trend among women in the increase in the incidence of malignant neoplasms in 0.03% in 2016 to 1.7% in 2015 and 2018. By the regions of the Republic, a high level of morbidity was revealed with an increase in the indicator in Batken, Issyk–Kul, Osh region and Osh city. The prevalence of malignant new growths of a mammary gland among women of the Kyrgyz Republic tended growth in the studied years for 1.5, 2.1, 1.7 and 1.9% respectively. Across the regions of the republic in all years the growth of the indicator was observed in Jalal–Abad, Issyk–Kul, Osh regions and Osh. There was also an increase in the Batken and Naryn regions, except in 2015. In 2018, compared to 2014, there was a decrease in female mortality from malignant neoplasms by 61.8% in terms of visibility. In terms of mortality from malignant breast neoplasms, there is a reverse trend among women of the Republic. Thus, the indicator increased by 107.6%. The main reasons for the high one-year fatality are the late appeal of patients to specialists, the lack of qualified personnel at the primary level of medical services, the absence of observation rooms in family medicine centers, the reduction of oncological caution of doctors and the population of the Republic. Screening of the female population and treatment of pre-tumor breast diseases should be carried out.
The Experience of Examination of Public Health in the Areas of Altai Krai Bordering the Drop Zones for Separating Parts of Launch Vehicles
Authors: Kolyado I. , Plugin S. , Shoikhet Ya.
Published: December 2019

As a result of space–rocket activity, a part of the territory of Altai Krai has been subjected to its negative effects for many years. With the support of the State Space Corporation ROSCOSMOS, there have been regular medical check-ups of the residents in the areas bordering the drop zones for separating parts of launch vehicles. The researches of the Scientific Research Institute of Regional Medical–Ecological Problems have developed a unique examination technique. The present work contains the results of a field medical examination of the residents of the said areas as well as the residents of the control area. Extensive and intensive indices of the prevalence of diseases have been obtained. Comparative analysis of the findings has been carried out. The most significant pathology has been detected in the main group and in control. The prevalence of the pathology in males and females differs. The general prevalence of the pathology and the prevalence of most classes in the test group is higher than in control. The significance of certain classes of pathology differs in the test group and in control.
Influence of the Nutrient Medium and Photoperiod on Tuberization of Potato Micro-plants of Promising Potato Varieties in vitro Culture
Authors: Vlasevskaya E. , Mukhametshin I.
Published: December 2019

The results of studies on the influence of the nutrient medium and photoperiod on tuberization of micro-plants of promising potato cultivars in an in vitro culture under are presented the conditions of a potato renewal laboratory at the Udmurt Research Institute of Agriculture of the Udmurt Federal Research Center of the Ural Branch of the Russian Academy of Sciences in 2018. Two experiments were carried out to identify patterns of the influence of potato cultivation conditions in vitro on the efficiency of its propagation and to develop an improved method for propagating potato micro-tubers in vitro. The experiments were carried out in accordance with the recommendation “New technologies for the production of healthy source material in elite potato seed production”, “Technologies for microclonal propagation of plants”. Object of research: micro-plants of potato varieties Alena, Charodei, Nayada. The studied variants of sugar concentration are 0%, 2% (control), 4%, 6%, 8%, 10%. The studied photoperiod options are 16 hours (control), 14 hours, 12 hours, 10 hours, 8 hours, 6 hours, 4 hours.
Based on the results of studies in 2018, experimental data were obtained. It was revealed that the lack of sugar in the nutrient medium negatively affects the growth and development of potato micro-plants. An increase in sugar concentration to 6–10%, in comparison with the control (2%), significantly increases the tuber-forming ability of micro-plants by an average of 6.1–7.2% and increases the number of tubers from one micro-plant. The highest yield of micro-tubers from one micro-plant on average for varieties was obtained with a 14-hour photoperiod and amounted to 1.3 pcs. With a 12-hour photoperiod, micro-tubers begin to form 7–14 days earlier than in the other variants of the experiment.
Necessity and Possibility of Introduction of New Minimum Technologies of Soybean Cultivation in the Amur Region
Authors: Epifantsev V. , Osipov Ya. , Vaitekhovich Yu.
Published: December 2019

The article considers the need for the use of minimum technologies for growing soybeans in the Amur region, which is due to: saving resources, increasing productivity and product quality, preserving and improving fertility, and preventing soil erosion. Possibility of application of the minimum technologies–correspondence of need of culture to soil and climatic conditions, machines and mechanisms to the sizes of fields and their relief, availability of the enterprises, material base and manpower. For soybean cultivation in the Amur region, minimum technologies in the recommended volume and sequence of technological operations are not applicable, but for other regions they are applicable. For their adaptation in the field it is necessary to combine different elements of the analyzed technologies.
Remote Observations of the State of Agricultural Crops
Authors: Babaeva A. , Guseinov A.
Published: December 2019

Shown are the stages of obtaining images of individual fields, regions and districts using satellites with a certain cyclicity. The possibility of obtaining information on the state of the land, including crop identification, determining the sown area of crops and the state of the crop, is being considered. In conclusion, it is concluded that phytopathological control using filming means is more effective since it becomes possible to get the most complete picture of the boundaries of the spread of the disease. This greatly simplifies the planning process and the organization of work to save the crop. It will also allow preserving tens of thousands of hectares of highly productive land in agricultural circulation.
Assessment of the Nursery of the Ecological the Experiment of the Udmurt Research Institute of Agriculture
Authors: Vlasevskaya E. , Mukhametshin I.
Published: December 2019

The results of studies of the best samples in the breeding nursery of the environmental test of 2018 are presented. Samples were obtained in the process of selection for a complex of biological and economically valuable traits that meet the conditions of the Udmurt Republic. The purpose of the research in 2018 is to create promising varieties of potatoes according to a complex of biological and economically valuable traits. Research conducted according to methods: Research methodology for potato culture, Methodological guidelines for technology of potato breeding. In the framework of agreements on joint scientific activity, hybrid combinations (single-tuber) were selected, bred by leading institutes of potato growing: All-Russian Scientific Research Institute of Potato Economy. Lorch, Falensky selection station, Ural Agricultural Research Institute. According to the results of 2018 studies in field breeding nurseries, including hybrid single-tuber combinations (42 combinations, 2453 tubers), 15 lines, 35 hybrids, 64 numbers, 13 promising numbers and 3 varieties of potatoes were studied. In the ecological experiment nursery, there were 16 numbers on the study, including the number 13–06–7 — the Tyuragai variety and 10–06–2 — the Zarni variety of the joint selection of the Udmurt Research Institute of Agriculture and the Falensky selection station (2016), 0–8–38 — a new variety Parus of joint selection of the Udmurt Research Institute of Agriculture and the Ural Research Institute of Agriculture (2018). Promising samples showed a yield of 34.9–38.7 t/ha, Tyuragai varieties (13–06–7) with a potato tuber yield of 35.8 t/ha and Zarni (10–06–2) with a potato tuber yield of 40.5 t/ha confirmed their suitability for cultivation in the region’s climatic conditions. The new Variety Parus (0–8–38) with a yield of 38.1 t/ha has established itself as a stable variety with high yields.
Influence of Fertilizer Norms on Root Mass, Nutrient Quantity and Chemical Composition of Lucerne
Authors: Khalilov S.
Published: December 2019

The results of the effect of fertilizers on the root mass, chemical composition and amount of alfalfa nutrients Medicago, (Fabaceae). Along with this, when the root mass is decomposed, the soil is enriched with mobile phosphorus compounds. It was found that the application of mineral fertilizers in the ratio of N60P90K60 significantly increases the root mass. An increase in root mass, along with an increase in organic matter, has a positive effect on the amount of nutrients in the soil, improves water–physical properties and increases soil fertility. 125.7–235.8 kg/ha of nitrogen, 26.1-58.7 kg/ha of phosphorus and 81.1–163.3 kg/ha of potassium enter the soil.
The Assessment and Management of Risks at Performance of Works on Multistage Hydraulic Fracturing
Authors: Eremenko K. , Kazakovtseva D. , Gudoshnik E. , Orlov A.
Published: December 2019

The article discusses the features of the application of the multi-stage hydraulic fracturing process. The dangers and risks of this process are identified.
The Study of the Content of Carboxylic Acids in the Resin of Uzgen Coal
Authors: Osekova G. , Tashpolotov Y. , Ysmanov E.
Published: December 2019

Methods for producing carboxylic acids from Uzgen coal resin are presented. Uzgen coal resin has high water content. The resin also contains mechanical impurities, for the separation of which sulfur ether was used. The proposed method allows you to effectively isolate carboxylic acids.
Recognition Handwriting and Printed Text for Software Requirements Engineering
Authors: Kaznin A.
Published: December 2019

This article discusses the problems of collecting software requirements. The existing computer vision technologies are analyzed and the choice of technology for recognizing handwritten and printed text is justified. The input data for the experiments are described and the results of character recognition for each image category are presented. A method of image preprocessing and recognition of text characters on mobile devices using parallel computing has been developed. On the basis of the proposed method, a prototype mobile application for collecting and digitalizing data obtained during the requirements engineering has been developed.
Research of Principles of Harmony in Design of Suit From Lace
Authors: Zelenova Yu. , Belgorodskii V. , Korobtseva N.
Published: December 2019

The research has been based on the theme of the proportioning of lace elements and costumes from lace cloths. In constructing the composition of the lace fabric, is necessary to apply natural scientific laws which stabilize the structure of the structure and the arrangement of parts in the whole. The geometrization of the space and the object environment prescribes a mathematical basis for constructing garments from lace and lace-like structures. As a result of visual analysis of designer collections created using lace clothes, it became necessary to search for the principles of natural harmony, which are basic in the detailed development of clothing items made from lace. The lace fabric is created from separate elements, which are also built according to the similar laws of harmony. The research aims are analyzing and adaptation of the existing natural–rational aesthetics laws. The basic laws of natural harmony include the principles of symmetry and asymmetry, the law of the ‘first’ golden ratio (basic) and the law of the ‘second’ golden ratio. These principles have the property of universal and mathematically accurate stylization of wildlife in the construction of objects of any sort of activity and the object environment. Mathematically formalized adaptation of the two fundamental laws of natural aesthetics (the first and the second laws of the golden ratio) using examples of designer models of costume and fragmentary lace elements has been a result of the research. The ratios of elements, parts, sides in lace clothes and models made from lace are absolutely true. The research hypothesis about the direct relationship between natural laws and the design of a rationally aesthetic structure of objects (items) has been confirmed. The absence of systematic laws during creating the structure of lace fabric and models from lace clothes is going to negatively affect human psycho-emotional perception, and, as a result, there will be an almost complete absence of interest to the designed object (item), which means negative demand.
Reengineering Business Processes as a Tool for Successful Business
Authors: Korolev G. , Barinov V.
Published: December 2019

Currently, most companies can select a number of methodologies to improve their business processes, including Six Sigma, Lean Six Sigma, Total Quality Management, Kaizen and Business Process Reengineering (BPR). Obviously, the choice of an appropriate methodology should be guided by the goals of the organization. In this regard, BPR is one of the best methodologies that can help companies ensure the continuity of their business so that they remain relevant for a long time. More importantly, BPR can help members rethink their existing practices and make significant improvements to the existing business process. The authors conducted a study of the theory of BPR. The main definitions are considered in detail, the essence of reengineering is revealed, five stages of implementation are named, possible positive and negative points in the process of BPR implementation are noted, examples are given. Based on the foregoing, it was concluded that companies that need to make changes in their business processes can adopt BPR as the most suitable methodology that will help to make improvements in their workplace.
Relationship Banking and Tax Secret
Authors: Ignatochkina D. , Repukhova D.
Published: December 2019

The authors of this article consider the problem of correlation of banking and tax secrets. The question raised is relevant, as the exact and concretized concepts of banking and tax secrets have not yet been fixed. However, this paper presents regulations that contain the concepts of banking and tax secrets, but it is also noted that they can be traced conflicts, as the fixed norms are different in scope and content, which causes problems with determining the responsibility of subjects of banking and tax secrets for their disclosure. If we talk about the relationship of these secrets, it should be noted that the priority has a tax secret, since credit institutions can be sanctioned for failure to provide the necessary information for the tax authorities. The authors also note that banking and tax secrecy play an important role in protecting the rights and freedoms of citizens protected by the Constitution of the Russian Federation. Based on this, it is concluded that banking and tax secrets belong to professional and official secrets respectively, that is, they will relate to information with limited access. Based on the special legal regime of these secrets, the authors directly affect the types of responsibility for their disclosure. Such liability includes: civil law, within the framework of labor legislation, administrative and criminal. Each responsibility has its own characteristics and problems, so the authors consider the problems of each of them. At the end of their work, the authors come to the conclusion about how necessary and important these two institutions are.
Ways of Logistics Improvement of the Freight Market
Authors: Gaffarov M.
Published: December 2019

Problems in the freight transportation market are considered: low solvency of customers, increase in the vehicle fleet and increased competition in the market, determination of tariffs for the transportation of goods based on the state of customers on idle cars, setting bonus tariffs in the same direction. The calculations and the sequence of actions for creating transport logistics are presented.
International Relations and Audit Process of Import Operations
Authors: Karimov N.
Published: December 2019

This article reveals the development of foreign economic activity in Uzbekistan, international relations and the audit process of import operations. It also sets out the legal basis for regulating foreign trade transactions carried out on the basis of international law and the terms of the foreign trade contract of sale. Foreign trade operations have also been studied, which have significant features due to legal regulation, the composition of foreign economic transactions, the procedure for fulfilling obligations under contracts and the system of applied calculations, which imposes additional requirements for accounting, analysis and audit.
Improvement of Accounting of Costs at Enterprises
Authors: Abdurakhmonov R.
Published: December 2019

The article considers the issues of improving cost accounting in enterprises, explores and draws relevant conclusions regarding approaches to the cost structure, optimizing costs based on improving the cost accounting methodology for enterprises, and improving accounting of inventories. The structure of sales costs was studied, and it was proposed to transfer some of the articles to other ‘recurring’ costs and take them into account. To keep track of expenses more clearly and in groups, it is advisable to formulate the costs of this large group based on the economic nature of their formation.
Assessment of Efficiency of Using Quiz Questionnaire to Increase Site Conversion
Authors: Smirnov V. , Perevalova A.
Published: December 2019

The article deals the theoretical and practical aspects of increasing the site’s conversion by improving its usability and, in particular, introducing a quiz survey. On the basis of the experiment, the effectiveness of this method was proved in comparison with the usual survey form.
On the Measures Against Corruption
Authors: Savvateeva V. , Tanskaya V.
Published: December 2019

Issues related to the development of corruption in the modern social system, as well as in Russia, are examined. The influence of corruption on social relations on the legal basis of the state’s existence is analyzed. In conclusion, it is proposed that the definition of corruption should have a legislative legal structure that does not exclude the legal definition of a qualifying sign of combating corruption crimes. In this case, it is possible to develop a mechanism for confiscating the property of a corrupt official. The essence of anti-corruption, in this case, is a sequential consideration of the causes of corruption in general, the facts of corruption in particular, the analysis of the information studied.