bluuebunny/crossref_metadata_2025 huggingface dataset:
PREPARATION OF PATIENTS WITH ДИСБИОЗОМ VAGINAS TO INTRAUTERINE INTERVENTIONS
Authors: Lugovaya Anzhelika Vasil'evna , Lugovaya A V
Published: October 2016

Last decade against a wide circulation of chronic infectious-inflammatory processes, number increases immmunodeficilis conditions, growth of number of diseases, sexually transmitted, the increasing value get associations of microorganisms and activation of is conditional-pathogenic microflora. At use of non-standard methods of diagnostics and treatment, at wrong treatment of diseases, the pathological conditions demanding their timely correction arise ignoring social and demographic factors. In our research for the purpose of preparation of patients with disbyosis vaginas to intrauterine interventions used a preparation from live apatogenitia sort bacteria "Bacillus" "Sporobakterin" possessing a wide spectrum of action who has allowed to lower several times frequency of relapses disbyosis in the postoperative period.
THE CONDITIONS OF PERSONNEL POTENTIAL FORMING IN NIZHNIY NOVGOROD REGION
Authors: Khaletskiy I G , Kamaev I A , Grib Maksim Nikolaevich , Perevezentsev Egor Aleksandrovich , Khlapov A L , Chalecki I G , Kamaev I A , Grib M N , Perevezentsev E A , Khlapov A L
Published: October 2016

The methods of approaching the solution of the personnel problems in the modern conditions and the forming, keeping and developing of medical personnel quality on the base of the analysis and assessing of main trends of personnel policy and exposure of present - day problems were consided.
Results microscopic examination of cavities filling teeth with various composite materials light-cured
Authors: Elgina A N , Morozova S I , Chen Wei , Ogneva A N
Published: October 2016

On the base of results of microscopic investigation of 66 human teeth with carious cavities, which are filled by light-cured materials, are removed from walls of carious cavities and stay on these walls only by small regions after the process of decalcination. Regions of Charisma Allert, Admira Flow, Valux Plus, Filtek Z250 have big size and are normally fixed on dentine of teeth. There is full loose of material in case of use of V.L.C. Composite.
Risk factors and quality of life in patients with benign prostatic hyperplasia
Authors: Sevryukov F A , Kamaev I A , Grib M N , Perevezentsev E A , Malinina O Y , Yelina J A
Published: October 2016

The article presents a review of the literature on the major issues propagation prevalence of benign prostatic hyperplasia, we consider the major risk factors for diseases, assess the quality of life, or patients with benign prostatic hyperplasia.
Mid-term results of combined endovascular and surgical treatment of cancer of the rectum
Authors: Korotkich N N , Olshanskiy M S
Published: October 2016

In this article new interventional method of preoperative simultaneous one stage selective lipiodol oil chemoembolization of the main rectal arteries is described. Essentionaly authors attempted transcatheter selective chemoembolization of different rectal arteries originated from different vascular system to improve clinical result of intra-arterial chemotherapy of rectal cancer. This method can be successfully used in complex treatment of locoregional rectal cancer. By objective methods such as MRI and ultrasound study positive influence of selective transcatheter chemoembolization of upper, middle and inferior rectal arteries on clinical condition of patients, resolving of partial colonic obstruction, significant decrease of the tumor size and reduction of number of lymphatic nodes were confirmed.
The role of antibodies to tireoperoksidaze when autoimmune orbitopathy
Authors: Lihvantseva V G , Sviridenko N Y , Rudenko E А , Gontyurova O А , Vygodin V A
Published: October 2016

The authors studied the role of antibodies to tireoperoksidaze when autoimmune orbitopathy in patients with Graves disease. It is shown that the presence at the TPO from HIV-positive patients with autoimmune thyroid closely correlates with higher rank the severity and intensity (amplitude) autoimmune inflammation in orbit. Findings allowed authors to ascribe the AL to SLIP risk factors increase the severity and activity of autoimmune orbitopathy in patients with Graves disease.
Physiological aspects of adaptation of cadets of academy FSIN of Russia to physical activities
Authors: Voronin R M
Published: October 2016

In this article some aspects of adaptation to physical activities of cadets of Academy FSIN of Russia are considered. 98 cadets with high (48 cadets) and low (50 cadets) success of physical training have been surveyed. In order to analyze the heart rate variability a complex "Varicard" and ISKIM-6 software have been used. Results of research specify in distinctions of mechanisms of adaptation in groups.
Influence of the thyroxine on the functional activity of the р-glycoprotein in the experiment
Authors: Yakusheva E N , Byryukova A S , Shchulkin A V , Nikiforova L V
Published: October 2016

In the research on the rabbits influence of a L-thyroxine on the activity of the protein- transporter Р-glycoprotein (Pgp) was studied. Activity of the Pgp was investigated on the pharmacokinetics of its marker substrate fexofenadine. It was established that introduction of a L-thyroxine within 14 days lead to dose-dependent rising of Рgp activity.
Current issues in health organization care in the penal colonystrict mode
Authors: Medvedevа O V , Ermolaeva T V , Yusufov R Sh
Published: October 2016

The paper presents an analysis of the activities of the medical service of penal colonies. The major issues of a complex therapeutic and preventive measures against prisoners with different levels of health.
Influence of metabolic syndrome on the course of bronchial asthma
Authors: Sysoevа M S , Solovievа A V , Nikiforov A А , Rakita D R
Published: October 2016

To estimate how metabolic syndrome influences the course of bronchial asthma we investigated 46 patients, 35 of them were diagnosed with metabolic syndrome. We established that in the patients with association of asthma and metabolic syndrome respiratory function and asthma control were significantly lower than in patients without metabolic syndrome. Also we established the inverse relation between the degree of obesity, abdominal type of obesity, the degree of arterial hypertension, fasting glycemia, atherogenous disturbances and the presence of diabetes. Hypocapnic disturbances were also found 2 times more frequently in asthmatic patients having metabolic syndrome.
Evaluation of quality of life and correlation carbohydrate metabolism, hormonal spectrum of patients with diabetes type 2 primary hypothyroidism, complicated distal neuropathy
Authors: Dubininа I I , Uryasev O M , Karapysh T V
Published: October 2016

The aim of the study was to study the dynamics of the quality of life, carbohydrate metabolism, hormonal spectrum, and their degree of correlation in patients with type 2 diabetes in combination with primary hypothyroidism complicated by distal neuropathy. We examined 62 patients with distal neuropathy. The study found that the fasting glucose level is high inverse correlation with the parameter self-assessment of mental health in patients with type 2 diabetes in combination with primary hypothyroidism. Compensation under the influence of hypothyroidism hormone replacement therapy improves quality of life of most patients with combined pathology: pain intensity, physical functioning, general health, vitality and self-assessment of mental health.
ESTIMATION OF HEALTH AND ADAPTATION POTENTIAL OF AN ORGANISM OF TEENAGERS GETTING THE PRIMARY VOCATIONAL EDUCATION
Authors: Kazaeva O V , Kiryushin V A , Stuneeva G Y
Published: October 2016

In this article there are the research results of health state and adaptation potential of teenagers, studying in institutions of the primary vocational education. The conclusion about the possibility of a differentiated approach at admission to the vocational education, carrying out of medical vocational guidance and medical professional consultation on the basis of account of the health state and individual peculiarities of an organism has drawn.
The effect of small doses of ionizing irradiation on histochemical characteristics of rats brain cortex
Authors: Ilicheva V N , Ushakov B N
Published: October 2016

Changes of activity of energetic metabolism enzymes were studied in rats brain cortex after a single exposure of irradiation in a dose of 0,5 Gy. The comparison of histochemical indicators in neocortex, archicortex and paleocortex has been carried out.
MORPHOLOGICAL CHANGES OF SMALL INTESTINE AT MICE BALB/C IN LONG-TERM PERIOD AFTER SPLENECTOMY
Authors: Nechay V V
Published: October 2016

The morphological changes of duodenum, jejunum and ileum of male mice Balb/c on the 30 th and 60 th day after experimental splenectomy were studied. The findings have shown the development of the adaptive processes, morphologically manifested in the rise of mitotic activity of epithelial cells of crypts and increase of portion of column epithelial cells per villus, as well as the tendency to decreasing of height of villi and depth of crypts of intestine.
COMPLEX ASSESSMENT OF CHRONIC TOXICITY OF THE PREPARATIONS FROM THE BIOMASS OF THE POLISCIAS FICIFOLIA BAILEY CELLULAR CULTURE AS PART OF ITS PRECLINICAL STUDY
Authors: Ryabkov A N
Published: October 2016

This work is devoted to a comprehensive experimental study of the possible toxicity of the preparations from the biomass of the poliscias filicifolia bailey cellular culture, administered for a long time in high doses.
Effect of combined application of ozone therapy and millimeter wave therapy on the clinical course of the postoperative period after surgery "sinus-lift"
Authors: Durnovo E A , Klochkov A S , Yanova N A , Kazakov A V , Marochkina M S , Sakharova S E
Published: October 2016

The possibility and effectiveness of ozone therapy and Millimeter wave therapy in the complex of therapeutic measures after surgery on the maxillary sinus (patent application number 2011137869 from 15.09.2011.) Using the presented method allows to reduce time of postoperative rehabilitation, which clinically manifested by a decrease in swelling, no pain and an earlier primary epithelialization of wounds, against a background of positive dynamics of laboratory data.
INFLUENCE OF RHINOSEPTOPLASTY ON CLINICAL ALLERGIC INDICES OF PATIENTS WITH ALLERGIC RHINITIS AND BRONCHIAL ASTHMA HAVING DEFLECTION OF NASAL SEPTUM
Authors: Polner S Aleksandrovich , Kozarenko E Aleksandrovich , Shevtsov E Aleksandrovich
Published: October 2016

The purpose of the present study is as follows: to determine the influence of rhinoseptoplasty on clinical allergic indices of patients with allergic rhinitis and bronchial asthma having deflection of nasal septum. An in-depth integrated examination was performed for 61 patients having deflection of nasal septum and suffering from allergic rhinitis and bronchial asthma. 10 patients with allergic rhinitis and bronchial asthma without deflection of nasal septum served as a control group. The work included clinico-laboratory, otolaryngologic, functional and allergological methods. It has been found, that patients with allergic rhinitis and bronchial asthma, having deflection of nasal septum, proved more severe clinical progression of allergic diseases. Timely performed rhinoseptoplasty allows to reduce the severity of clinical progression and the frequency of allergic disease exacerbation, as well as to improve efficiency of pharmacotherapy applied to allergic rhinitis and bronchial asthma.
SYNTHETIC DIRECT ANTIOXIDANT IONOL AS A PROMISING MEANS OF ANTI-CATARACT TREATMENT
Authors: Kolesnikov A V
Published: October 2016

Conservative treatment of cataract, being the most common cause of reduced vision, is aimed at correcting certain metabolic disorders of crystalline lens and is of little efficiency. Currently, they recognize the free radical theory as the main theory of cataract pathogenesis, however, in the arsenal of conservative therapy there are no drugs with proven direct antioxidant activity. Ionol is a classic synthetic phenolic antioxidant, which is used as a drug in different fields of medicine for diseases associated with oxidative stress, but in ophthalmology ionol has not been previously used. Given the above, it is reasonable and relevant to study ionol as a promising means of anti-cataract treatment.
ESTIMATION OF DNA FRAGMENTATION, ACONITASE ACTIVITY AND CITRATE LEVEL UNDER TYPE 2 DIABETES AT RAT AND INTRODUCTION OF MELATONIN
Authors: Agarkov A A , Popova T N , Matasova L V , Popov S S , Iskusnykh I Y , Sklyarova E I
Published: October 2016

Fragmentation of DNA from rat liver under type 2 diabetes has been observed. Furthermore, aconitase (EC 4.2.1.3) activity in rat liver and blood under this pathology is decreased in comparison with control group. Along with this fact the level of citrate in researching tissues is increased. Changes investigating parameters towards norm at introduction of melatonin were established, that is connected probably with realization of antioxidant action of the hormone.
ETIOLOGIC CHARACTERISTICS OF OPPORTUNISTIC INFECTIONS IN PATIENTS WITH HEMATOLOGICAL MALIGNANCIES IN THE NORTHERN REGION OF THE RUSSIAN FEDERATION
Authors: Bulieva N B , Ushakov V F , Shashkova T V
Published: October 2016

Immunological processes in the blood of cancer are being studied intensively at the present time, both domestic and foreign researchers. The range of possible directions of research in this area is quite wide. However, the published reports on this subject does not relate to the specifics of individual diseases, and only partially characterize some immunological parameters.
DEVELOPMENT AND PHARMACOKINETIC STUDIES CHILD DRUG FORM -SUPPOSITORIES WITH ARBIDOL
Authors: Vorobyov A N , Ovcharov M V , Potanina O G , Abramovich R A
Published: October 2016

Carried out the development of arbidol rectal form. Shown possibility of creating dosage form of the antiviral drug for children based on the domestic substances. Carried out of pharmacokinetic studies, determined the basic pharmacokinetic parameters of the bioavailability of suppositories containing arbidol.
DEMOGRAPHIC TENDENCIES IN THE RYAZAN REGION
Authors: Artemyeva G B , Geht I A
Published: October 2016

Healthcare reform and modernization shall definitely take into account changes in citizens’ needs for medical care. That’s why population structure studies, its change anticipation, demographic tendencies analysis play a significant role in the industry planning. For years Ryazan has been considered a region with a regressive type of a population structure wherein the number of people older than working age is higher comparing to the people younger than working age. It’s necessary to increase public health efficiency in order to improve the demographic situation. It can be possibly reached due to the optimization of the organization, the amount and structure of the provided medical care on basis of demographic determinants and their tendencies analysis.
PROGNOSTIC EFFECT OF BLOCKADE OF THE RIGHT BUNDLE BRANCH BLOCK PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
Authors: Molyanova A A , Nikulina N N
Published: October 2016

The study analyzes the influence on the prognosis of blockade of the right bundle branch block in patients with acute myocardial infarction. Score the prognostic value of blockade of the right bundle branch block was carried out in comparison with a group of patients without intraventricular conduction disturbances, and a group of patients with left bundle branch block. Established negative prognostic effect of blockade of the right bundle branch block in patients with acute myocardial infarction, and this negative effect was maintained after 30 days a year, 3 years.
PECULIARITIES OF DIAGNOSTICS AND TREATMENT POSTTRAUMATIC HEMOBILIA
Authors: Huseinov A Z , Karapysh D V , Petushkov L L
Published: October 2016

The article describes the exploration and currency of posttraumatic hemobilia in the surgical department. The frequency of the disease is 0,18 - 3%. The lethality in case of hemobilia is still high (20-40%) in spite of the new diagnostic and treatment methods usage. The concrete clinic example demonstrates probable mistakes in diagnostics and possible methods to liquidate them; the algorithm of treatment is defined. The article describes further ways of posttraumatic hemobilia diagnostic improvement in the conditions of the surgery department in Russian Federation. The method of selective angiography should be installed necessarily as an invasive method of diagnostics and treatment of these conditions in the stationary of the 21 st century.
"PAID" MEDICINE IN THE RUSSIAN FEDERATION: THEORY AND PRACTICE
Authors: Boyko I B , Boyko O I
Published: October 2016

Actual problems of national health care - health care in the "paid" and "free" versions. Author's opinion on this issue is based on the provisions of the legislation in the health and status of the delivery of health services.
DIAGNOSTIC VALUE OF THE IMMUNE TO ASSESS THE SEVERITY OF LYMPHOPROLIFERATIVE DISEASE, COMPLICATED BY AN OPPORTUNISTIC INFECTION
Authors: Bulieva N B , Pachotina V A , Korkin A L , Uschakov V F , Schaschkova T V , Chermeneva N M
Published: October 2016

We have studied the results of the survey of cellular and humoral immunity in 260 patients lymphoproliferative diseases, complicated by the development of opportunistic infections. The study of the immunological characteristics of the cells allows you to set the source of origin of the pathological clone of the total diversity of morphologically similar forms limphoproliferativee disease.
INFLUENCE OF DEMOGRAPHIC AND TERRITORIAL FACTORS ON PHARMACOEPIDEMIOLOGICAL CHARACTERISTICS OF MEDICINES SUPPLY FOR ASTHMATIC PATIENTS
Authors: Karakulova E V
Published: October 2016

The pharmacoepidemiological research of medicines supply for asthmatic patients with the influence of the demographic characteristics of patients and a territorial factor was made. The Defined Daily Dose methodology was used. It was determined more intensive consumption of asthma controller therapies in the regional center and more intensive use of symptomatic therapy in the regional districts. Differences in using anti-asthmatic drugs between groups of patients differentiated by sex and age were also found.
ORGANIZATION OF MULTILEVEL SYSTEM TO THE CARDIAC PATIENTS IN PENZA REGION
Authors: Chizhova O V , Sopina N V , Konovalov O E
Published: October 2016

The work presents the results of the analysis of multilevel system of medical care to cardiac patients in Penza region. It is shown that the introduction stage care system which helps patients with diseases of the circulatory system brings positive results, positive affects to demographic processes in the region.
SURGICAL TREATMENT OF MORBID OBESITY
Authors: Yudin V A , Usachev I A , Melnikov A A
Published: October 2016

The paper presents the material with the problems of surgical treatment of patients with severe obesity. On a sufficient factual material provides an assessment of all the authors of the applied methods of bariatric operations, dynamics of decrease in weight. Attention is drawn to the causality of the development of complications and methods of their treatment. Estimated remote (over three years) the results of operations.
THE LOWER LIMB FUNCTIONAL STATE IN PATIENTS WITH THE KNEE INTRA-ARTICULAR FRACTURES AFTER TREATMENT USING THE ILIZAROV FIXATOR COMBINED WITH ARTHROSCOPY
Authors: Dolganova T I , Sizova T V , Karasev E A , Karaseva T Yu , Karasev A G
Published: October 2016

The results of treatment using the Ilizarov fixator combined with arthroscopy in 39 patients (38±4.5 years) with the knee intra-articular fractures have been analyzed clinically and physiologically. The functional state of the lower limb muscles has been evaluated depending on the type of feet support responses using the techniques of dynamometry and electromyography. Significant changes in the stride cycle parameters were registered in case of 40% asymmetry of the moment of force values of leg flexors/extensors and 1.0 values of the index of antagonist muscles. When the antagonist index was 0.5 the ability to maintain the body stable balance in walking was disordered, and the patients had to use additional supports. Attention should be primarily focused to the recovery of the anterior group of femoral muscles in patients with Type I feet support responses, and to that of both the anterior and posterior groups of femoral muscles - for patients with Type II. Treatment-and-rehabilitation measures should be directed to the function recovery of femoral and leg muscle groups for Type III of feet support responses.
PECULIARITIES OF TREATMENT AND PROPHYLAXIS OF INITIAL CARIES AND CHRONIC CATARRHAL GINGIVITIS
Authors: Galizina O A
Published: October 2016

The article is devoted to the review of the modern literary data regarding peculiarities of treatment and prophylaxis of initial caries and chronic catarrhal gingivitis use phyto medicines. The role of microorganisms in appearance and progression of caries and diseases of marginal periodont is described in article. Usage of medicines on the base of plants is the most perspective trend in prophylactic medicine nowadays. Phyto medicines cause bactericide, anti-inflammatary, analgetic, reparative actions combined with absence of disadvantages.
MORPHOFUNCTIONAL CHARACTERISTICS OF THYROID GLAND OF MALE WISTAR RATS IN CASE OF PROLONGED ALCOHOL CONSUMPTION UNDER THE CONDITIONS OF VOLUNTARY INTAKE
Authors: Mkhitarov V A , Makarova O V
Published: October 2016

The aim of the work: the investigation of the morphofunctional features of the thyroid gland of male Wistar rats depending on the dose of consumed alcohol under the conditions of voluntary intake. The levels of thyrothrophin (TSH), triiodothyronine (T3), thyroxin (T4) and morphometric parameters of thyroid gland were estimated. Depending on the individual alcohol consumption three subgroups of rats were distinguished: with low (3,14±0,19 g/kg per day), medium (7,23±0,54 g/kg per day) and high consumption (13.51±1.12 g/kg per day). TSH concentration increased for the animals with medium and low consumption, being within normal limits for the animals with high consumption. The T4 level decreased in groups with medium and high consumption, T3 decreased only in the group with medium consumption. Under the conditions of voluntary intake alcohol induced an apparent activating effect onto the thyroid gland independently of the dose, which consisted in a mass increase and the increase of the nuclei area and thyrocyte height. The detected differences in rat alcohol consumption and the intensity of the activation signs of the thyroid gland under the conditions of voluntary intake can be stipulated by the genetically determined body properties.
PASSIVE AVOIDANCE BEHAVIOR AFTER STRESS EXPOSURE OF RATS IMMUNIZED BY GLUTAMATE-BSA CONJUGATE
Authors: Umryukhin A E , Chekmareva N Yu , Sotnikov S V , Vetrile L A , Zaharova I A
Published: October 2016

Behavior of rats in passive avoidance task was studied after their immunization by glutamate-BSA conjugate. Active rats immunized by conjugate displayed decreased avoidance of aversive stimuli when tested after stress exposure. It may be concluded that immunization by glutamate conjugate is accompanied in active rats by reorganization of avoidance behavior after stress.
HYGIENIC AND EPIDEMIOLOGICAL ASPECTS OF THE WORK OF MODERN OBSTETRIC FACILITIES
Authors: Kiriushin V A , Kotelevets E P
Published: October 2016

The main indicators of the quality of the art medical facilities are the lack of infections associated with medical care (IHS) for patients and staff, low level of occupational diseases. These indicators can provide only a set of preventive measures aimed at improving the quality of patient care and safety of personnel.
DISEASES OF THYROID GLAND AS RISK FACTOR IN PRIMARY OPEN ANGLE GLAUCOMA DEVELOPMENT
Authors: Lichvantseva V G , Korosteleva Ye V , Tabeyeva K I , Vygodin V A
Published: October 2016

Glaucoma is a multifactor disease. The data concerning the correlation between the pathology of thyroid gland and glaucoma appeared at the end of the last century. The revealing of the disease spread plays an important role in confirming the connection of glaucoma development on the background of thyroid gland disease.
EFFECT OF THE DEGREE OF IMMUNOSUPPRESSION AND HIGHLY ACTIVE ANTIRETROVIRAL THERAPY ON SERUM IL-17 AND IL-10 LEVEL IN PATIENTS WITH HIV-INFECTION
Authors: Zhyvytsia D G
Published: October 2016

We analyzed IL-17 and IL-10 serum levels in HIV-infected patients with different stage of disease, degree of immunodeficiency and treatment. We observed 70 patients with HIV infection. Among the patients studied 44 patients on antiretroviral therapy. HIV infection is marked increase in the concentration of IL-10, especially in patients with severe immunosuppression (CD4 200 ml-1). In HIV-infected patients with severe immunosuppression, which do not receive highly active antiretroviral therapy, there is an increase of IL-10 and IL-17 in serum, which may indicate a systemic immune activation.
THE MEDICAL ACTIVITY OF PATIENTS WITH BRONCHIAL ASTHMA
Authors: Uryasev O M , Konovalov O E , Kicha D I
Published: October 2016

The paper presents the characteristics of medical activity of 414 patients in the Ryazan Regional Hospital. The issues of the regularity of observing and passing medical examinations, compliance with the doctor's recommendations, self-medication are considered taking into account gender features.
The functional mechanisms of the white line of the abdomen and their role in the pathogenesis of ventral hernia
Authors: Fedoseyev A V , Muravev S J , Avdeev S S , Gazuani A I
Published: October 2016

The article gives a detailed analysis of the scientific work and their own data for the last ten years devoted to the problem of treatment of patients with umbilical hernias. Covered in detail and summarized the practical experience of various authors on the surgical treatment of patients with this pathology. Identified the causes of relapse and development periomphalic umbilical hernia in the postoperative period . Based on a detailed analysis of morfofuntional and biomechanical properties of the fascial- musculo- aponeurotic complex abdominal wall author justifies the use of prosthetic techniques in closing the defect of the umbilical ring.
The state of the autonomous (vegetative) nervous system and heart rhythm disorders under exercise conditions
Authors: Pokhachevsky A L , Lapkin M M
Published: October 2016

Ingenious methods of exercise cardiac rhythmgram math simulation are used to study the autonomic regulation of the heart rate. Changes in a number of autonomic nervous system (ANS) - an increase in activity in general, and the manifestation of parasympathetic dominance reflects improved exercise tolerance. Supraventricular extrasystole, a typical heart beat disorder which is not observed at rest and manifesting under exercise conditions, is a consequence of its excess (overload) independently of the endurance development level. Improvement of adaptive mechanisms in the formation of endurance reduces the possibility of extrasystole due to the increase of a potentially dangerous load threshold, manifestation time and decrease in the number of extrasystole complexes. In turn, heart beat disorders have fundamental differences in the vegetative base depending on the endurance development level.
Causes of length of conotruncus of embryonic mouse heart at normal condition and under the maternal dehydration
Authors: Dyagovets K I , Tverdokhleb I V
Published: October 2016

This work presents the histogenetic transformation from conotruncus of embryonic mouse heart (С57BL/6) under the normal and experimental condition. It was establish the reason of the shortening of the conotruncus of embryonic heart was delayed physiological proliferative activity of the cells of myocardial cuff during our research.
Role of ATP-dependent K + channels in erythropoietin effects on abdominal organs volumetric blood flow velocity at ischemia/reperfusion
Authors: Pokrovsky M V , Alehin S A , Ivanova L V , Nazarenko D P , Kolmikov D I
Published: October 2016

In this article erythropoietin influence on volumetric blood flow velocity in different abdominal organs at early ischemia/reperfusion stages were shown. We determine that glibenclamid as mitochondrial ATPdependent K+ channels blocker abolish erythropoietin protective effects, increasing transient hyperemia, at the same time pancreas has reaction different from other abdominal organs to ischemia/reperfusion and pharmacological agents intake.
Anomalies of kidneys development among the children with idiopatic scoliosis of Ryazan region
Authors: Pankratova G S
Published: October 2016

The aim: to study the anatomical and topographical peculiarities of urineflowing system organs among the children with idiopatic scoliosis. This work was based on the results of the kidneys ultrasound research carried out among 425 children with idiopatic scoliosis with Cobb ’s angle from 5 to 60 degrees. Children from 4 to 17 years old were under the research. It was shown that the anomalies of urineflowing system organs development exceed population indexes many times. Ultrasound research of kidneys should be included in the obligatory diagnostic investigation of children with idiopatic scoliosis.
Remote results of surgical treatment of benign thyroid disease in elderly patients
Authors: Aristarkhov V G , Danilov N V
Published: October 2016

In this work, the authors give a theoretical substantiation thyroid resection elderly patients with thyroid disease. Also tell about their own experience of operations on the thyroid gland. In the work has distans results of treatment which were analyzed 120 patients who operated 5 years ago owing to nodular goiter in volume terms: resection, subtotalthyroidectomy, hemithyroidectomy and totalthyroidectomy. Euthyroidism was observed only in the group resection in 48% and subto-talthyroidectomy in 17,2%. In hypothyroidism and compensation was difflcaet due to accompanying pathology of the cardiovascular system.
Change of cytomorphometric indicators before and after ortofen and dioksidin ointments treatment in patients with mild hypertrophic gingivitis, edematous form
Authors: Biriukova U A , Morozova S I , Fuks E I
Published: October 2016

The article is devoted to study change of cytomorphometric indicators of gum’s mucous membrane of a dabs prints before and in various terms after treatment hypertrophic gingivitis, edematous form, ortofen and dioksidin ointments.
Feedback and time factor in systemic organization of purposeful behavior of a human in reproduction of visual images
Authors: Merkulova M A , Lapkin M M , Kulikova N A
Published: October 2016

The subject of the article is a study of systemic organization of purposeful behavior of a human in reproduction of visual images. Exposure time of visual images and role of feedback in purposeful behavior of different degree of successfulness are studied in test objects. On the basis of variability of the cardiac rhythm, a different degree of correlation relationships between characteristics of reproduction of visual images and parameters of “physiologic value” of the activity is demonstrated in individuals with different degree of successfulness of the activity.
Characteristics of management of patients with inflammatory bowel diseases in Ryazan region
Authors: Nizov A A , Yakubovskaya A G , Koldynskaya E I
Published: October 2016

The efficacy analysis of patient management in inflammatory bowel diseases is provided in the article. The most frequent mistakes in medicament prescription are reviewed. The data are shown on prevalence and management of anemia in this group of patients. The information is given on quality of life in patients with inflammatory bowel diseases and it's connection with the characteristics of the diseases course.
INDUCERS OF THE REGULATORY FACTOR TO HYPOXIA ADAPTATION
Authors: Levchenkova O S , Novikov V E
Published: October 2016

The review is devoted to the analysis of the modern conceptions about role of specific regulatory protein HIF-1α (hypoxia-inducible factor-1alpha) in the mechanisms of adaptation to hypoxia. Experimental and clinical results of using of different HIF-1α inducers (inhibitors of HIF-1α degradation and inactivation, activators of transcription and translation of HIF-1α) to activate the processes of immediate and delayed organism adaptation to hypoxia is discussed in the article. This approach opens promising opportunities for effective pharmacotherapy of cardiovascular and other diseases with hypoxia and ischemia in their pathogenesis.
CELL AND CELL-MATRIX INTERACTIONS IN BREAST CARCINOMA: THE PRESENT STATE OF PROBLEMS
Authors: Mnikhovich M V
Published: October 2016

In an article, on the analysis of literature data, studied and intercellular ceU-matkrisnyh interactions in breast tumors. Analyzed in the data that are important for understanding the processes of intercellular interactions and patterns of tumor growth. Tumor microenvironment is important for the regulation of tumor status.
CHANGES IN BALANCE OF T-HELPER SUBSETS IN THE GALT OF RATS UNDER CHRONIC ZOOSOCIAL STRESS AND MODULATION OF THE INTESTINAL MICROFLORA
Authors: Topol I A , Kamyshny A M
Published: October 2016

It was investigated the influence of chronic zoosocial stress (ZSS) and modulation of the intestinal microflora composition on the ratio of T-helper subsets in GALT. It has been established that ZSS development was accompanied by an imbalance Tbet+/Gata3+- and Foxp3 +/Roryt +-cells, indicating the dominance of Th1- and Th17-differentiation and increasing levels of pro-inflammatory signaling in the gut. It was shown that the introduction of kanamycin to the stressed rats leads to the dominance of Th1- and Treg subsets, but modulation of the intestinal microflora lactobacterine reduces the ratio of Tbet +/Gata3 + - lymphocytes in the own lamina of mucous membrane of the fibres, increases in subepithelial zone and increases unidirectionally the ratio of Treg/Th17.
SPECIFICS OF POLYMORPHISMS OF GENES OF AGO1, DGCR8, GEMIN4, DROSHA IN PATIENTS WITH HYPERTENSION AND POST-INFARCTION CARDIOSCLEROSIS
Authors: Shcheglova N E , Kalinkin M N
Published: October 2016

A total of 30 men with hypertension and 20 men with post-infarction cardiosclerosis were examined. The analysis of association of polymorphisms of genes which participate in a biogenesis of microRNAs (miRNAs), such as AGO1 (A/G), DGCR8 (G/A), GEMIN4 (A/G), DROSHA (A/C) with a frequency of hypertension and post-infarction cardiosclerosis is carried out. The association between a genotype of AA of a gene of GEMIN4 and risk of development of hypertension is found. The results indicated about important role of this genotype in pathogenesis of hypertension, but mechanisms of realization of its effects aren’t studied.
ORAL HORMONAL CONTRACEPTIVE "YARINA" INFLUENCE ON P-GLYCOPROTEIN FUNCTIONAL ACTIVITY
Authors: Kotljarova A A , Yakusheva E N
Published: October 2016

In the research on rabbits influence of combined oral contraceptive "Yarina" on the functional activity of the protein efflux transporter P-glycoprotein (Pgp) was studied. Pgp activity was assessed by pharmacokinetic analysis of marker substrate fexofenadine. It was found that administration of the drug "Yarina" for 14 and 21 days resulting in inhibition of Pgp functional activity.
LABORATORY EVALUATION OF EFFICIENCY USE OF HERBAL REMEDIES IN THE TREATMENT OF HYPERTROPHIC GINGIVITIS
Authors: Biriukova U A , Filimonova L B , Galizina O A
Published: October 2016

The article is devoted to studying of change of eytological indicators of gum’s mucous membrane in dabs prints before and after treatment of hypertrophic gingivitis, edematous form use herbal remedies and ortofen ointment.
ANALYSIS OF MORPHOLOGICAL AND FUNCTIONAL CHANGES OF PHYLOGENETICALLY DIFFERENT AREAS OF THE CEREBRAL CORTEX IN RATS
Authors: Ilicheva V N , Shtemberg A S
Published: October 2016

In experiment conducted on outbred white male rats, irradiated with a single dose of 1.0 Gy, morphological changes of neurocytes in neo- , archi- and paleocortex were analyzed within 18 months after the exposure. The obtained regression equations enable to count the time elapsed after irradiation, on the data of morphofunctional state of nerve cells in irradiated animals.
CLINICAL AND ENDOSCOPIC CHARACTERISTICS OF ACUTE EROSIVE-ULCEROUS PATHOLOGY OF THE UPPER GASTROINTESTINAL TRACT IN PATIENTS OF HEMORRHAGIC FEVER WITH RENAL SYNDROME, LEPTOSPIROSIS AND TULAREMIA
Authors: Maleyev V V , Martynov V A , Klochkov I N
Published: October 2016

The article shows the results of endoscopic and morphological studies of pathology of the upper gastrointestinal tract (GIT) in 174 patients of both sexes with hemorrhagic fever with renal syndrome (HFRS), leptospirosis and tularemia. The high frequency of erosive and ulcerative and hemorrhagic changes in the gastrointestinal mucosa due to deep microcirculatory disorders. We found that changes of mucosa interrelated with leading clinical and laboratory parameters, severity and time of occurrence of the underlying disease. We considered variants of gastrointestinal pathology in connection with abdominal syndrome. The study showed associating defined erosive and ulcerative lesions of gastric and duodenal ulcer with Helicobacter pylori infection. We have established the optimal time for endoscopic examination - this is the first day of hospitalization. This allows you to quickly identify the erosive ulcerous pathology until complications carry out, to hold adequate correction of treatment and reduce the risk of bleeding, which greatly improves the prognosis of the disease.
BIOLOGY OF HUMAN DENDRITIC CELLS AND THEIR ROLE IN INFECTIOUS DISEASES
Authors: Tsvetkov V V , Sologub T V , Tokin I I
Published: October 2016

Dendritic cells are a heterogeneous human population of professional antigen-presenting cells. They are known to play a critical role in the regulation of both innate and acquired immune response. The functional activity of dendritic cells depends on the action signals microenvironment. Of particular interest is the study of the role of dendritic cells in the pathogenesis of various infectious diseases in humans.
REGIONAL FEATURES OF RISK FACTORS IN THE ETIOLOGY OF BREAST CANCER
Authors: Schumova L M , Denisenko A N , Iordanskaya N A
Published: October 2016

The article presents the incidence of breast cancer among women living in the Nizhny Novgorod region for the period from 2010 to 2012, given the medico-social characteristics of the patients, analyzed and evaluated risk factors for breast cancer, shows the need for primary and secondary prevention of this disease.
Significance of immunohistochemistry method for diagnosing of stomach tumors
Authors: Shponka I S , Poslavskaya A V , Yakovenko V R
Published: October 2016

The article is dedicated to the diagnosis of malignant tumors of the stomach, analyzing divergences of diagnoses after routine morphological researches and immunomorphological methods with monoclonal antibodies using, assessment of proliferative activity of different groups of tumors of this localization. Our investigation demonstrated that in the group of gastric tumors mistaken primary diagnoses were identified in 33 of 62 cases (53.2%). Proliferative score estimation is too important to determine the potential for malignancy of gastrointestinal stromal tumors and the degree of differentiation of neuroendocrine cancers.
On the concept of extreme
Authors: Kharitonov V I
Published: October 2016

The paper deals with the theoretical and practical aspects of modern problems with extreme positions and the use of the conceptual apparatus of the quantitative component of the problem. It is noted that to date there is no single point of view on the concept of "extreme" and his close concepts and definitions. It is shown that there should be a universal approach to the problem of the unity of which must be expressed through the rationale of quantitative characteristics of existing factors and performance responses of the body.
The ifluens of new oxypyridine derivative on the development of toxic hepatitis
Authors: Klimkina E I
Published: October 2016

In conditions of experimental toxic lesion of the liver, hepatoprotective effect of the original chemical compound 2,6-dimethyl-3-oxypyridine adamantane carboxylate has been investigated. It has been shown that this compound effectively reduces the activity of liver enzymes (aspartic and alanine transaminases, lactate dehydrogenase), the content of total bilirubin and activity of free radical oxidation initiated by CCl 4 intoxication. The protective action of the substance on the liver function has been confirmed morphologically.
Endothelial function in patients with diabetes mellitus type 2 with arterial hypertension in good compensation of hyperglycemia
Authors: Pertseva N O
Published: October 2016

The purpose of this study was to quantify markers of endothelial function in patients with diabetes mellitus type 2 with arterial hypertension in good compensation of hyperglycemia and determining their relation to hemodynamics, renal function and lipid profile. The analysis showed that with good compensation of hyperglycemia endothelial dysfunction is formed before the appearance of clinical and laboratory signs of renal dysfunction and dyslipidemic disorders, accompanied by significant increase in the concentration of endothelin-1 (more than 4 times) and nearly 3-fold increase in the content of von Willebrand factor and thrombomodulin compared with the control group.
The comparative characteristic clinical-psychological features of adolescent patients with mild mental retardation, depending on the form of the stay
Authors: Afonina A K , Volodin B Y
Published: October 2016

The article presents the results of studying clinical-psychological features 120 adolescents with mild mental retardation in age from 12 to 18 years old with different forms of the stay (boarding school or family). In the study, they were revealed significant differences in the clinical picture, self-esteem and satisfaction basic needs.
Change active recovery of small intestinal mucosa under the cyclophosphamide influence, and its correction by drugs that stimulate digestive tract tissue repair
Authors: Bondarchuk A O , Fomim L V , Gavriliouk A A , Mnikhovich M V , Zherebyateva S R
Published: October 2016

A.O. Bondarchuk, L.V. Fomina, A.A. Gavriliouk, M.V. Mnikhovich, S.R. Zherebyateva The article presents the results of research of recovery activity of mucosal cells of the small intestine based on mitotic and apoptotic index. Proved that benzofurokain and metyluracil stimulate recovery of small intestinal mucosa; benzofurokain faster than metiluratsil normalizes recovery activity of small intestinal mucosa damaged by cyclophosphamide.
Peptic ulcer and trophological status of patients
Authors: Butov M A , Zhestkova T V , Maslova O A
Published: October 2016

Anthropometric characteristics of patients with peptic ulcer with underweight and normal indicator of body mass index found isolated or combined protein and energy malnutrition. The quality of life of patients with peptic ulcer and the rate of ulcer healing are associated with nutritional features of body. The velocity of cicatrization of ulcer defect has a significant positive correlation with the percentage of fatty body mass in patients with peptic ulcer. The proposed index reflecting nutritional status and leukocyte formula predicts the rate of ulcer healing. Patients with the debut of peptic ulcer have greater adherence to treatment, compared patients with recurrent disease.
Comparative prognosis in eldery and senile patients with Q-myocardial infarction during 12 months of observation depending on different schemes of reperfusion therapy
Authors: Bellil S , Yakushin S S , Aksentev S B , Yunevich D S
Published: October 2016

In this article we studied the prognosis of various schemes of reperfusion therapy and subsequent medical treatment during a year of observation in elderly and senile patients with ST elevation myocardial infarction. We examined 80 patients, 46 of them were elderly, and 34 were senile patients. Revealed that the combined endpoint (death, cardiovascular complications) between elderly patients (1 st grp) and senile patients (2 nd grp) who received thrombolytic therapy was less significant, and in patients without reperfusion therapy it was more significant in the second group.
PROBLEMS OF HYGIENE AND ECOLOGY IN RELATION TO A PROBLEM OF ECOLOGICALLY CAUSED INCIDENCE
Authors: Kharitonov V I
Published: October 2016

In article from hygienic and ecological positions the review of material on a problem of ecologically caused incidence in interrelation with processes of change of environment is stated. Modern approach to a problem environment - health of the person which main shortcoming is absence of the accounting of prevalence of the prepathological states having the criteria and predictive importance is sounded. It is emphasized that today there are no bases to denial of ecological incidence, and it should be revealed in the general stream of diseases. Allocation of "ecological medicine" as the independent scientific and practical direction is necessary and to realize official statistics with registration of ecologically reasonable incidence in relation to the international classification of diseases.
IMPACT OF ENVIRONMENTAL STATUS CHILD MORBIDITY IN ASTRAKHAN
Authors: Kolomin V V , Rybkin V S , Filyaev V N
Published: October 2016

The paper presents the results of a study of health and demographic indicators, indicating the priority of air pollution populated areas of road transport emissions, a key factor in the environment, have a negative impact on the health of the child population. The necessity of the development and implementation of measures aimed at reducing air pollution of the city.
AMINO-ACID COMPOSITION OF UROLOGICAL HERBAL TEA
Authors: Selezenev N G , Popov D M , Selezenev G N
Published: October 2016

Qualitative quantitative amino-acid composition of urological herbal tea “Uvaur” which includes manzanita leaves, tickseed, birch gemmae. 19 amino acids are determined in the herbal tea, 9 of which are indispensable. The total content of amino acids is 6,998%, in which 12,34% glutamic acid, 10,38% aspartic acids, 8,69% leucine.
AN ANALYSIS OF PROBABLE MECHANISMS OF ANTIDEPRESSANT ACTIVITY OF NEURONAL N-METHYL-D-ASPARTATE RECEPTOR BLOCKERS
Authors: Abramets I I , Evdokimov D V
Published: October 2016

Slow appearance of therapeutic action and partial therapeutic efficiency of used today antidepressants demand otherwise approaches for creation on principle new antidepressants. One from prototypes such drugs is ketamine possessing by capacity fast to suppress the symptoms of refractory depression. However a nature of antidepressant activity did not ascertained decisively. The most popular hypotheses of antidepressant action of ketamine and other N-methyl-D-aspartate receptors blockers were analyzed in this review.
FEATURES OF PANCREATICODUODENAL REGION BLOOD SUPPLY IN THE SURGICAL TREATMENT OF CHRONIC PANCREATITIS
Authors: Pronin N A , Pavlov A V
Published: October 2016

The study showed that the head of the pancreas and duodenum receive arterial blood from the anterior and posterior of the pancreatic-duodenal arcs. Posterior arc gives to the intestine more branches than the anterior one. Its impotent during an operations when elements of the anterior arc were ligated. Also found that the inferior pancreatic artery, dorsal pancreatic artery, arteries are interchangeable. Both arteries in one complex were not found.