bluuebunny/crossref_metadata_2025 huggingface dataset:
Accessing Targeted Therapies: A Potential Roadblock to Implementing Precision Oncology?
Authors: von Itzstein Mitchell S. , Smith Mary L. , Railey Elda , White Carol B. , Dieterich Julianne S. , Garrett-Mayer Liz , Bruinooge Suanna S. , Freedman Andrew N. , De Moor Janet , Gray Stacy W. , Park Jason Y. , Yan Jingsheng , Hoang Anh Quynh , Zhu Hong , Gerber David E.
Published: May 2021

PURPOSE:

Advances in genomic techniques have led to increased use of next-generation sequencing (NGS). We evaluated the extent to which these tests guide treatment decisions.

METHODS:

We developed and distributed a survey assessing NGS use and outcomes to a survey pool of ASCO members. Comparisons between groups were performed with Wilcoxon two-sample, chi-square, and Fisher's exact tests.

RESULTS:

Among 178 respondents, 62% were male, 54% White, and 67% affiliated with academic centers. More than half (56%) indicated that NGS provided actionable information to a moderate or great extent. Use was highest (median ≥ 70% of cases) for lung and gastric cancer, and lowest (median < 25% of cases) in head and neck and genitourinary cancers. Approximately one third of respondents reported that, despite identification of an actionable molecular variant, patients were sometimes or often unable to access the relevant US Food and Drug Administration–approved therapy. When NGS did not provide actionable results, individuals reporting great or moderate guidance overall from NGS in treatment recommendations were more likely to request the compassionate use of an unapproved drug ( P < .001), enroll on a clinical trial ( P < .01), or treat off-label with a drug approved for another indication ( P = .02).

CONCLUSION:

When NGS identifies an actionable result, a substantial proportion of clinicians reported encountering challenges obtaining approved therapies on the basis of these results. Perceived overall impact of NGS appears associated with clinical behavior unrelated to actionable NGS test results, including pursuing off-label or compassionate use of unapproved therapies or referring to a clinical trial.
Thyroid Hormone Deiodinases: Dynamic Switches in Developmental Transitions
Authors: Hernandez Arturo , Martinez M Elena , Ng Lily , Forrest Douglas
Published: May 2021

Thyroid hormones exert pleiotropic, essential actions in mammalian, including human, development. These actions depend on provision of thyroid hormones in the circulation but also to a remarkable extent on deiodinase enzymes in target tissues that amplify or deplete the local concentration of the primary active form of the hormone T3 (3,5,3′-triiodothyronine), the high affinity ligand for thyroid hormone receptors. Genetic analyses in mice have revealed key roles for activating (DIO2) and inactivating (DIO3) deiodinases in cell differentiation fates and tissue maturation, ultimately promoting neonatal viability, growth, fertility, brain development, and behavior, as well as metabolic, endocrine, and sensory functions. An emerging paradigm is how the opposing activities of DIO2 and DIO3 are coordinated, providing a dynamic switch that controls the developmental timing of a tissue response, often during neonatal and maturational transitions. A second paradigm is how cell to cell communication within a tissue determines the response to T3. Deiodinases in specific cell types, often strategically located near to blood vessels that convey thyroid hormones into the tissue, can regulate neighboring cell types, suggesting a paracrine-like layer of control of T3 action. We discuss deiodinases as switches for developmental transitions and their potential to influence tissue dysfunction in human thyroid disorders.
WNT4 Balances Development vs Disease in Gynecologic Tissues and Women’s Health
Authors: Pitzer Lauren M , Moroney Marisa R , Nokoff Natalie J , Sikora Matthew J
Published: May 2021

The WNT family of proteins is crucial in numerous developmental pathways and tissue homeostasis. WNT4, in particular, is uniquely implicated in the development of the female phenotype in the fetus, and in the maintenance of müllerian and reproductive tissues. WNT4 dysfunction or dysregulation can drive sex-reversal syndromes, highlighting the key role of WNT4 in sex determination. WNT4 is also critical in gynecologic pathologies later in life, including several cancers, uterine fibroids, endometriosis, and infertility. The role of WNT4 in normal decidualization, implantation, and gestation is being increasingly appreciated, while aberrant activation of WNT4 signaling is being linked both to gynecologic and breast cancers. Notably, single-nucleotide polymorphisms (SNPs) at the WNT4 gene locus are strongly associated with these pathologies and may functionally link estrogen and estrogen receptor signaling to upregulation and activation of WNT4 signaling. Importantly, in each of these developmental and disease states, WNT4 gene expression and downstream WNT4 signaling are regulated and executed by myriad tissue-specific pathways. Here, we review the roles of WNT4 in women’s health with a focus on sex development, and gynecologic and breast pathologies, and our understanding of how WNT4 signaling is controlled in these contexts. Defining WNT4 functions provides a unique opportunity to link sex-specific signaling pathways to women’s health and disease.
“May Day, 2020”
Authors: Clare Eli
Published: May 2021

“May Day, 2020” is a poem by Eli Clare, who is white, disabled, and genderqueer and lives near Lake Champlain in occupied Abenaki territory (currently known as Vermont) where he writes and proudly claims a penchant for rabble-rousing.
Six Types of Waiting in Berlin, 2017
Authors: Kim Christine Sun , Cachia Amanda
Published: May 2021

In Six Types of Waiting in Berlin, Christine Sun Kim’s drawings provide a fascinating constellation of cultural and sensorial experiences with time. Originally from the United States, the artist shares her account of how time (and waiting) is measured differently according to the cities in which she has lived, with each place having its own advantages and drawbacks. While each environment in which one must tediously wait—an immigration office, the health insurance office, the doctor’s office, the bank, an art supplies shop, and the grocery store—is familiar, the subtext of the drawings is how the artist’s relationship with time is also measured by her style of communication. Kim uses American Sign Language and asks questions in a written form using an iPhone on a daily basis as she goes about her chores. “Crip time” is thus also punctuated by the pauses in writing/scrawling questions, in reading, and the creativity involved in ad-lib responding between deaf and non-deaf sensorial modalities.
Afro-American Literature: The Analysis of Gorilla, My Love by Toni Cade Bambara
Authors: Kustinah Kustinah , Haryanti Sri , Yuwono Suhud Eko , Sholihah Umi
Published: May 2021

It is said that Afro-American literature is the body of literature produced in the United states by writers of African descent. Today, Afro-American literature has become accepted as an integral part of American literature. In broad terms, Afro-American literature can be defined as writings by people of African descent living in the United States. This qualitative study analyzes a short story entitled Gorilla, My Lovewritten by a female Afro-American writer, Toni Cade Bambara. The analysis of the study aims at answering the three problem formulation: (1) states the literariness of the text (2) explains how the literariness of the text play as a means to symbolize a “broader” text (the universe) and (3) writes the proof of mental evidences taken from the text. In analyzing the short story, this study uses Sociology of Literature and Psychology of Literature. The two theories help readers understanding the theme of the short story by reading the explanation about how the narrator of the story set the plot. This study uses narrative as its approach since this is a literary study where a short story is analyzed through its narrative structure. The conclusion of the study provides the proof of its research benefits: giving information to readers about the following: (1) all about Afro-American literature plus its life-experience, family-values, etc. (2) how a literary work can connect its readers to their life and (3) an understanding that a reading-act strengthens the definition that a literary work is as a portrait of human experience.
The Heroine Concept in a Filipino Graphic Narrative
Authors: Arroyo Estrella T.
Published: May 2021

This study explored the concept of “HEROINE” in the context of “Darna,” a Filipino graphic narrative written by Mars Ravelo that was first published on May 13, 1950 by Filipino Komiks. Extracted from the 27 episodes of “Darna” are realities of experience as well as innuendos related to the real character of Darna, the super heroine. Further, the study delved into a deeper meaning of heroine beyond its lexical meaning. As a result, the researcher formulated her own definition of “HEROINE” as “Humaneness and Equanimity in Reimagining Optimistic, Iconic, Novel, and Empowered” persona, which led to the findings that, indeed, Darna has reached her apotheosis as a superheroine. These insights were not fathomed had it not been for the researcher’s focus on close reading, application of Expressive Realism, and “Argustic” reading. Keen eyes are needed to enjoy reading a graphic narrative which is both visual and verbal. The study proved that in Philippine society, Darna is the most accepted, loved and idolized Filipino icon as savior of a devastated and crippled society after World War II. Lastly, it is aimed that this humble analysis will put itself into the realm of a body of Pop Literature and the Humanities.
Stereotype of Racial issue on #starterpack
Authors: Ayedoji Hakeemi Harris
Published: May 2021

Semiotic comes from Greek word which is semeion (sign). Yet, generally, semiotics is a study which concern about the existence of sign in society. We could find sign everywhere, from the form of words, images, objects, etc. Thus, the object of semiotics could be anything. But, Charles Sanders Pierce explain sign in a different way. According to Pierce’s study, something could be categorized into sign if it could be taken part in the triadic relation. Semiotic study is used in analizing the research. The main data of this research is the #starterpack tweets in Twitter. The data used is focused in the #starterpack tweets with white and black people context from 2019-2020. While the supporting data for this research are from the journals, books, internet sources, and dictionaries. To collect the data, the research used the observation method and use note technique. While, the research used the triadic signs in by Charles Sanders Pierce to analyze the data. From the analizing, the researcher got 40 #starterpack tweets with mostly 4 images in it. Those tweets could be divided to 20 white people #starterpack and 20 black people #starterpack tweets. All the data are analyzed with the triadic signs which are signs, objects, and interpretations. The signs that had been analyzed show objects and interpretations which lead to the gap between white and black people. Those gaps then lead to stereotypes on white and black people. Moreover, the data lead to 6 factors of stereotypes. Those factors are nationatility, personal integrity, curiosity, adaptation, homogeneus neighborhood, and common shared information.
An Experiment in Active Learning: The Effects of Teams
Authors: Ludwig Jeffrey
Published: May 2021

In modern times, the importance of education cannot be overstated. Beyond the acquisition of knowledge, perhaps the most important aim of education may be the development of character in individuals, including vitality, courage, sensitiveness, and intelligence, from which our society may experience increased prosperity, peace, and freedom. In this paper we address the daunting challenge of achieving successful, widespread, and inclusive university education. How do we enliven and engage the students in our classrooms? How can we help each and every student in the class self-actualize and reach the highest potential for learning? Active learning is one well-established and potent solution for accelerating the accumulation of knowledge. In this paper, an experiment in active learning utilizing team-based adaptive online quizzes in an introductory math finance course involving 378 undergraduate students over two years is conducted to explore the potency of this active learning methodology compared to a control group with traditional teaching. We find active learning unambiguously improves knowledge accumulation in the individual students, while simultaneously bolstering inclusive excellence across all students in the class, as measured by a relevant and meaningful quantitative metric. The paper concludes with a discussion comparing the quality of active vs. traditional teaching methods and offers interpretations of the quantitative results. The results of this paper support the widely accepted theme in the literature that active learning has a positive effect on student performance in STEM (Science, Technology, Engineering, and Math) courses.
MODISSA: a multipurpose platform for the prototypical realization of vehicle-related applications using optical sensors
Authors: Borgmann Björn , Schatz Volker , Hammer Marcus , Hebel Marcus , Arens Michael , Stilla Uwe
Published: May 2021

We present the current state of development of the sensor-equipped car MODISSA, with which Fraunhofer IOSB realizes a configurable experimental platform for hardware evaluation and software development in the context of mobile mapping and vehicle-related safety and protection. MODISSA is based on a van that has successively been equipped with a variety of optical sensors over the past few years, and contains hardware for complete raw data acquisition, georeferencing, real-time data analysis, and immediate visualization on in-car displays. We demonstrate the capabilities of MODISSA by giving a deeper insight into experiments with its specific configuration in the scope of three different applications. Other research groups can benefit from these experiences when setting up their own mobile sensor system, especially regarding the selection of hardware and software, the knowledge of possible sources of error, and the handling of the acquired sensor data.
Decoding different working memory states during an operation span task from prefrontal fNIRS signals
Authors: Chen Ting , Zhao Cui , Pan Xingyu , Qu Junda , Wei Jing , Li Chunlin , Liang Ying , Zhang Xu
Published: May 2021

We propose an effective and practical decoding method of different mental states for potential applications for the design of brain-computer interfaces, prediction of cognitive behaviour, and investigation of cognitive mechanism. Functional near infrared spectroscopy (fNIRS) signals that interrogated the prefrontal and parietal cortices and were evaluated by generalized linear model were recorded when nineteen healthy adults performed the operation span (OSPAN) task. The oxygenated hemoglobin changes during OSPAN, response, and rest periods were classified with a support vector machine (SVM). The relevance vector regression algorithm was utilized for prediction of cognitive performance based on multidomain features of fNIRS signals from the OSPAN task. We acquired decent classification accuracies for OSPAN vs. response (above 91.2%) and for OSPAN vs. rest (above 94.7%). Eight of the ten cognitive testing scores could be predicted from the combination of OSPAN and response features, which indicated the brain hemodynamic responses contain meaningful information suitable for predicting cognitive performance.
Coherent propagation of a half-cycle unipolar attosecond pulse in a resonant two-level medium
Authors: Arkhipov Rostislav , Arkhipov Mikhail , Babushkin Ihar , Pakhomov Anton , Rosanov Nikolay
Published: May 2021

Here we numerically investigate the propagation of unipolar half-cycle attosecond pulses with a duration much shorter than the period of the proper oscillations

T
0

of the medium and its relaxation times

T
1

and

T
2

in a two-level resonant absorbing and amplifying medium. We find that despite breaking down of the famous McCall and Hahn area theorem, some phenomena described by this theorem are still qualitatively preserved. In particular, it is shown that pulses with small initial electric pulse area become sign-alternating upon the propagation, similar to the traditional

0
π

pulses; pulses with

4
π

,

5
π

, and

6
π

area are unstable and split into lower-order pulses, exactly as in the long-pulse case. The electric pulse area conservation rule and limitations of unipolar pulse amplification in two-level gain media, which follows from this rule, are discussed.
Photonic arbitrary waveform generation based on the temporal Talbot effect
Authors: Chi Hao , Wang Shanyi , Yang Shuna , Zhai Yanrong , Zou Xihua , Yang Bo , Li Qiliang
Published: May 2021

In this paper, we propose a novel photonic approach for generating arbitrary waveform. The approach is based on the property of real-time Fourier transform in the temporal Talbot effect, where the spectrum of the modulating analog signal is converted into the output time-domain waveform in each period. We present a concise and strict theoretical framework to reveal the relationship of real-time Fourier transform between the optical signals before and after the dispersion. A proof-of-concept experiment is implemented to validate the presented theoretical model. We propose to generate symmetrical or asymmetrical arbitrary waveforms by using double-sideband or single-sideband modulation, respectively, which is verified by simulation results. It is shown that the given approach can be used to generate a repetition-rate multiplied optical pulse train with arbitrary waveform by simply using a multi-tone RF signal with appropriate frequencies and powers.
Spectral linewidth narrowing of two broad-area blue laser diodes (445  nm) with a common external cavity
Authors: Nyaupane Parashu R. , Likamwa Patrick L. , Braiman Yehuda
Published: May 2021

Two watt-level broad-area laser diodes were simultaneously locked into a common external cavity made using a surface grating in a Littrow configuration. The spectral linewidth of the combined laser beam was narrowed down from over a nanometer to 10–15 pm (FWHM), and the output power was the sum of the power of the individually locked laser diodes. The spectrum of the combined laser beam can be tuned over a range of 2–3 nm by changing the tilt angle of the grating and varying the injection currents of each laser diode.
Fiber endface photoacoustic generator for quantitative photoacoustic tomography
Authors: Yang Guang , Huang Hengbo , Luo Hongbo , Kou Sitai , Amidi Eghbal , Achilefu Samuel , Zhu Quing
Published: May 2021

We demonstrate a novel fiber endface photoacoustic (PA) generator using infrared (IR) 144 laser dye dispersed within an ultraviolet adhesive. The generator provides a wide acoustic bandwidth in the transducer frequency range of 2–7 MHz, high thermal conversion efficiency (

>

90
%

), good PA signal controllability (well-controlled IR 144 concentration), and high feasibility (simple procedures). Through a series of experimental validations, we show that this fiber-based endface PA generator can be a useful tool for a broad range of biomedical applications such as calibrating the local absorption coefficient of biological tissue for quantitative PA tomography.
Watt-level europium laser at 703  nm
Authors: Loiko Pavel , Rytz Daniel , Schwung Sebastian , Pues Patrick , Jüstel Thomas , Doualan Jean-Louis , Camy Patrice
Published: May 2021

We report on a watt-level highly efficient europium laser operating at the

5

D

0

→

7

F

4

transition. It is based on the stoichiometric

K
E
u

(

W
O

4

)
2

crystal. Under pumping by a green laser at 532.1 nm, the

K
E
u

(

W
O

4

)
2

laser generated a maximum peak output power of 1.11 W at

∼

703

n
m

with a slope efficiency of 43.2% and a linear polarization (

E
‖

N
m

). A laser threshold as low as 64 mW was achieved. True continuous-wave operation was demonstrated. The polarized emission properties of monoclinic

K
E
u

(

W
O

4

)
2

were determined.
Statistical inconsistency of the unrooted minimize deep coalescence criterion
Authors: Alanzi Ayed A. R. , Degnan James H.
Published: May 2021

Species trees, which describe the evolutionary relationships between species, are often inferred from gene trees, which describe the ancestral relationships between sequences sampled at different loci from the species of interest. A common approach to inferring species trees from gene trees is motivated by supposing that gene tree variation is due to incomplete lineage sorting, also known as deep coalescence. One of the earliest methods motivated by deep coalescence is to find the species tree that minimizes the number of deep coalescent events needed to explain discrepancies between the species tree and input gene trees. This minimize deep coalescence (MDC) criterion can be applied in both rooted and unrooted settings. where either rooted or unrooted gene trees can be used to infer a rooted species tree. Previous work has shown that MDC is statistically inconsistent in the rooted setting, meaning that under a probabilistic model for deep coalescence, the multispecies coalescent, for some species trees, increasing the number of input gene trees does not make the method more likely to return a correct species tree. Here, we obtain analogous results in the unrooted setting, showing conditions leading to inconsistency of the MDC criterion using the multispecies coalescent model with unrooted gene trees for four taxa and five taxa.
Cerebral oxygen saturation and cerebrovascular instability in newborn infants with congenital heart disease compared to healthy controls
Authors: Tran Nhu N. , Votava-Smith Jodie K. , Wood John C. , Panigrahy Ashok , Wee Choo Phei , Borzage Matthew , Kumar S. Ram , Murray Paula M. , Brecht Mary-Lynn , Paquette Lisa , Brady Kenneth M. , Peterson Bradley S.
Published: May 2021

Objective

Infants with Congenital Heart Disease (CHD) are at risk for developmental delays, though the mechanisms of brain injury that impair development are unknown. Potential causes could include cerebral hypoxia and cerebrovascular instability. We hypothesized that we would detect significantly reduced cerebral oxygen saturation and greater cerebrovascular instability in CHD infants compared to the healthy controls.

Methods

We performed a secondary analysis on a sample of 43 term infants (28 CHD, 15 healthy controls) that assessed prospectively in temporal cross-section before or at 12 days of age. CHD infants were assessed prior to open-heart surgery. Cerebral oxygen saturation levels were estimated using Near-Infrared Spectroscopy, and cerebrovascular stability was assessed with the response of cerebral oxygen saturation after a postural change (supine to sitting).

Results

Cerebral oxygen saturation was 9 points lower in CHD than control infants in both postures (β = -9.3; 95%CI = -17.68, -1.00; p = 0.028), even after controlling for differences in peripheral oxygen saturation. Cerebrovascular stability was significantly impaired in CHD compared to healthy infants (β = -2.4; 95%CI = -4.12, -.61; p = 0.008), and in CHD infants with single ventricle compared with biventricular defects (β = -1.5; 95%CI = -2.95, -0.05; p = 0.04).

Conclusion

CHD infants had cerebral hypoxia and decreased cerebral oxygen saturation values following a postural change, suggesting cerebrovascular instability. Future longitudinal studies should assess the associations of cerebral hypoxia and cerebrovascular instability with long-term neurodevelopmental outcomes in CHD infants.
Structural characterisation of the Chaetomium thermophilum Chl1 helicase
Authors: Hodáková Zuzana , Nans Andrea , Kunzelmann Simone , Mehmood Shahid , Taylor Ian , Uhlmann Frank , Cherepanov Peter , Singleton Martin R.
Published: May 2021

Chl1 is a member of the XPD family of 5’-3’ DNA helicases, which perform a variety of roles in genome maintenance and transmission. They possess a variety of unique structural features, including the presence of a highly variable, partially-ordered insertion in the helicase domain 1. Chl1 has been shown to be required for chromosome segregation in yeast due to its role in the formation of persistent chromosome cohesion during S-phase. Here we present structural and biochemical data to show that Chl1 has the same overall domain organisation as other members of the XPD family, but with some conformational alterations. We also present data suggesting the insert domain in Chl1 regulates its DNA binding.
Conceptualizing communities of truth on YouTube
Authors: Lange Patricia G.
Published: May 2021

Commentary on YouTube has been characterized as a ‘cesspool’. Yet, participants with divergent opinions do post comments to exchange ideas and share information. This study analyses comments posted to a video about YouTube community to investigate the site’s potential for knowledge exploration. The study analyses whether commentary dynamics exhibit those found in prior scholars’ rubric of acommunity of truth. This model rejects hierarchical forms of learning and advocates sincere information sharing and evaluation. The article argues that certain strands of media ecology scholarship are commensurate with the principles of a community of truth, in which knowledge seekers deploy digital environments to collectively explore a subject of inquiry – in this case the potential for establishing a YouTube community. Such a knowledge subject does not exist as a pre-defined object in the world but rather emerges through digital interaction that channels the subject’s desires about its ideal form through YouTube comments.
Analisis Hashtag pada Twitter untuk Eksplorasi Pokok Bahasan Terkini Mengenai Business Intelligence
Authors: Himawan Arif , Maarif Muhammad Rifqi , Aesyi Ulfi Saidata
Published: May 2021

The main purpose of this paper is to examine the dominant topics about Business Intelligence in micro-blogging Twitter. There are 7.153 tweets collected from Twitter API. Text mining and natural language processing are used to analyze the dominant topics among those tweets. Computational method used to count the most frequent hashtag that appears together with Business Intelligence hashtag. Twitter users are large and scattered around the world with a diverse range of skills (expertise) that can give a new perspective on a subject that may not be predicted before. For example, for topics related to Business Intelligence, the very dominant general topic discussed in the scientific literature are about data management, as well as for analytics and machine learning data. The result contributes to understanding dominant topics about Business Intelligence that can help researchers to level their research.
Analisis Sentimen Review Halodoc Menggunakan Nai ̈ve Bayes Classifier
Authors: Hendra Asep , Fitriyani Fitriyani
Published: May 2021

Healthcare service has the role to help and serve people to access medical services, i.e. providing medicines, medical consultation, or health control. Healthcare service has been transforming to a digital platform. Halodoc is one of the digital platforms that people can use for free or paid, user can also give reviews of Halodoc’s performance and services on Google Play Store to give feedback that Halodoc can use to evaluate and improve the app. The Google Play Store review is increasing every day. Therefore an analysis for the review with sentiment analysis for Halodoc’s review is needed, first phase of sentiment analysis for the review is preprocessing which has tokenization, transform to lower cases, filter stopword, dan filter token (by length) processes. The data is divided into two positive and negative classes with cross-validation and a k-fold validation value of 10, using Naïve Bayes Classifier algorithm with 81,68% accuracy and AUC 0.756, categorized as fair classification.
Senior High School Students’ Anxiety and Performance in Learning English
Authors: Sansaluna Saima , Bawa Lydia , Camua Amour , Untong Leonel
Published: May 2021

This study focused on the anxiety and performance of the students in learning English specifically in speaking. It sought to find out anxieties and its causes that affect their English performance in terms of inter-language phonology, grammar and meaning system. The study covered the use of Foreign Language Classroom Anxiety Scale (FLCAS) developed by Horwitz et al. (1986) that measure the English learners’ anxiety levels while learning English in the classroom. The respondents of the study were the selected Grade 12 senior high school students from the selected public schools in Maguindanao Division, Philippines. Descriptive-correlational survey method was used in the study.

The findings show that English language speaking anxiety does exist among Senior High School students in Maguindanao Division and their level of anxiety in learning English is high. It is further concluded that students’ anxiety levels in speaking English in terms of inter-language phonology, inter-language grammar and inter-language meaning system contributed to students’ performance in learning in English.
The Influence of Applying the Principles of Experiential Coyote Drama (ECD) Methods in Teaching English Language from the English language supervisor’s perspectives in Jenin city (case study).
Authors: Barahmeh Mosaddaq , Bsharat Tahani
Published: May 2021

This paper sheds light on the importance of applying the Principles of   Experiential Coyote Drama (ECD) Methods in Teaching English Language from the English language supervisor’s perspectives in Jenin city (case study). First of all, this paper discloses the Coyote teaching method. Later, this paper also explains the importance of Experiential learning in teaching English as a Foreign Language.  It also explains the educational drama and its techniques in teaching-learning the English language. Finally, this paper suggests a new teaching-learning method which is Experiential Coyote Drama (ECD). All in all, from the previous studies and researches the researchers found that mixing educational drama with Experiential learning and Coyote method will bring a full package of new methods and activities for the teachers, learners and future researchers in teaching English as a Foreign Language.
STATION ROTATION MODEL WITH ICT INTEGRATION ENHANCES STUDENTS’ PROBLEM SOLVING SKILL IN PHYSICS
Authors: Unsi Alibai , Cauring Alnoury , Camua Amour , Dalgan Norma
Published: May 2021

Station rotation model has recently become a promising innovation in education in which learners lead to deeper learning and problem-solving development (Jones, 2018). The study determined the effectiveness of station rotation model with ICT integration to enhance the problem solving skill of ninth grade students of ARMM Regional Science High School during five weeks of intervention. The data of this study were obtained from the pre-test and post-test with open-ended questions from Control and Experimental Groups. These tests were administered before and after the intervention and scored using rubric. Moreover, attitude test was answered by the students to provide feedbacks on the use of station rotation model with ICT integration. Results revealed that there is no significant difference in the post-test performances under the Control Group (K-12 teaching instruction) and the Experimental Group (SRM with ICT Integration), t (25) =-1.324, p=.197. At the end of the study, experimental group under station rotation model with ICT integration does not significantly enhance students’ problem solving skill in Physics.
Pharmacist Impact on Physician Practices Related to Diabetes Management
Authors: Ammar Amina , Darghali Lindsay M. , Tarraf Wassim , Berlie Helen D. , Jaber Linda A.
Published: May 2021

To examine the impact of a pharmacist’s physical presence on (1) the achievement of individual and combined targets for hemoglobin A1c (A1C), blood pressure (BP), and low-density lipoprotein cholesterol (LDL-C) (composite target), and (2) physician practices in relation to the American Diabetes Association (ADA) standards of medical care.

 

Methods

A retrospective, comparative study of randomly selected diabetic patients seen within an underserved primary care setting at least twice annually between June 1, 2018- December 31, 2019. Patients were allocated by whether they had received care in one of the physician-pharmacist clinics (Group A) or the physician-only clinic (Group B). Study outcomes included the proportion of patients achieving the composite and individual treatment targets for A1C, BP, and LDL-C.

 

Results

A total of 394 patients were included; Majority were underserved African Americans. The composite target was attained by 20% of participants in Group A and 13% in Group B (p=0.09). There were no statistically significant differences in achievement of individual targets between groups. A significantly higher proportion of participants in Group A achieved better control of diastolic blood pressure control (85% vs. 74%), had microalbuminuria tested (50% vs. 12%), were prescribed aspirin (43% vs. 32%), and had lower utilization of non-insulin glucose-lowering agents relative to those in Group B.

 

Conclusion

The impact of a pharmacist’s physical presence on physician practice demonstrated a general trend towards improvement in clinical outcomes related to diabetes management. Future studies are needed to further characterize the impact provided by the physician-pharmacist relationship.
Analysis of the Gyeonggi Bay Ecomuseum as a Wide-Area Ecomuseum
Authors: Lee Hanju
Published: May 2021

This study aims to examine the features of the creation and operation of ecomuseums at wide-area and (metropolitan) local government levels and to analyze their improvements and limitations based on an analysis of a case study on the “Gyeonggi Bay Ecomuseum.” This study also reveals the necessity and direction for ecomuseums led by metropolitan local governments. It attempts to find ways to expand the Gyeonggi Bay Ecomuseum and apply lessons from this ecomuseum to other planned wide-area ecomuseums in South Korea. Overall, this study intends to derive the sustainability of wide-area ecomuseums, and their utility and potential as a means to revitalize the region. 

The Gyeonggi Bay Ecomuseum is a meaningful case study as it was created in a wide area called the Gyeonggi Bay and was led by a metropolitan local government, along with the official claim as an ecomuseum; the museum creation project also progressed in a phased approach. However, there are issues such as organization problems of the ecomuseum and the absence of resident participation, integrated programs, and an archive center. 

Therefore, this study presents measures to overcome these obstacles: the establishment of a core ecomuseum and an exhibition center, the development of joint programs, the continuous security of funds and human resources, and measures to generate economic benefits for residents. This study also suggests spatial/functional expansion from being the “Gyeonggi Bay Ecomuseum” to the “Gyeonggi Province Ecomuseum.”

 

Keywords: Ecomuseum, Wide-area unit, Lead of local governments, Gyeonggi Bay, Regional revitalization
Smart classroom environments affect teacher-student interaction: Evidence from a behavioural sequence analysis
Authors: Zhan Zehui , Wu Qianyi , Lin Zhihua , Cai Jiayi
Published: May 2021

This study investigated the effect of classroom settings on teacher-student interaction in higher education by comparing the behavioural sequences in smart classrooms (SCs) and traditional multimedia classrooms (TMCs). Twenty in-classroom teaching sessions were randomly selected from six universities in South China, involving 1,043 students and 23 teachers. Half of the sessions were taken in SCs as the experimental group, and half were in TMCs as the control group. A teacher-student interaction behaviour coding schema was developed, and a total of 17,805 observable behaviours were collected and coded sequentially via a review of classroom videos. Then, the behavior pattern diagram was set up to visualise a lag sequential analysis results by four themes, namely teacher-talk, teacher-action, student-talk and student-action. Results show that compared to TMCs, the SCs triggered significantly more self-initiated student actions and student-driven teacher talk, while teacher-initiated talk decreased significantly, indicating that students’ autonomy was strengthened in the SC. Furthermore, teachers’ workload was somewhat reduced, and they obtained more support with trying new pedagogies with mobile terminals in the data-rich environment. These findings provide evidence to validate the effect of SCs on increasing teacher-student interaction and strengthening the students’ dominant position.
Establishing the Noise: Interday Ecological Reliability of Countermovement Jump Variables in Professional Rugby Union Players
Authors: Howarth David J. , Cohen Daniel D. , McLean Blake D. , Coutts Aaron J.
Published: May 2021

Howarth, DJ, Cohen, DD, McLean, BD, and Coutts, AJ. Establishing the noise: interday ecological reliability of countermovement jump variables in professional rugby union players. J Strength Cond Res 36(11): 3159–3166, 2022—The purpose of this study was to examine the interday “ecological” reliability of a wide range of ground reaction force–derived countermovement jump (CMJ) variables. Thirty-six male, professional rugby union players performed 3 CMJs on 4 separate days over an 8-day period during the first week of preseason. We calculated reliability for 86 CMJ variables across 5 interday combinations using 2 criteria: mean output across 3 jump trials (Mean3) and single output from the highest jump (BestJH). Interday coefficient of variation (CV) of the 86 variables in each CMJ phase, for Mean3 and BestJH, respectively, ranged between concentric = 2–11% and 2–13%; eccentric = 1–45% and 1–107%; and landing = 4–32% and 6–45%. Mean3 interday CV was lower in all 86 variables across every interday combination, compared with BestJH. CVs were lower in our cohort than previous studies, particularly for eccentric phase variables. There was no meaningful difference between interday conditions, suggesting any 2-day combination conducted within the first 8 days of preseason, represents a measure of “noise.” We did not apply arbitrary reliability “cut-offs” used in previous work (e.g., CV <10%); therefore, our analysis provides reference reliability for a wide range of CMJ variables. However, we recommend that practitioners assess reliability in their athletes, as it is likely to be environment, protocol, and cohort specific.
Sources of Challenge to Charismatic Authority in Newly Emerging Religious Movements
Authors: Bromley David G.
Published: May 2021

Charismatic authority has been alternatively depicted as extraordinarily powerful and fragile and transitory. The argument developed here is that organizations generally, and newly emerging religious movements in particular, are sites of both coordination and contestation. If new movements are established with a charismatic authority structure, one important question is from what sources can challenges to that authority emanate. Three movement sectors are identified as potential sources of challenge: inner circle leadership, administrative functionaries, and grassroots membership. Using illustrative cases from contemporary emerging religious movements, instances of authority challenges are presented in support of the argument that both coordination and contestation are normal features of movement development.
Propiedades morfológicas y estructurales en óxidos de grafeno y óxidos de grafeno reducido
Authors: Bazán A , Akashi L , Quintana M , Champi Ana
Published: May 2021

En este trabajo, se utilizó polvo de grato como material inicial para obtener óxidos de grafeno (GO). Proponemos la reducción de los óxidos de grafeno, por un método físico-químico, que consiste en una reducción térmica y química en presencia de NaBH4 para obtener óxidos de grafeno reducidos (RGO). Además, la presencia de grupos funcionales y el tamaño de los nanocristales se determinaron por el método de Visive, FTIR y espectroscopia Raman en ambas muestras, GO y RGO. De este modo, observamos que el uso del método físico-químico para obtener RGO produce una disminución signicativa de defectos, como lo demuestra la banda D del espectro Raman que prácticamente desaparece después de esta reducción. Además de esto, un estudio morfológico realizado por AFM ha mostrado supercies planas relativas en las muestras de nano-grafeno obtenidas por la técnica presentada.
Colour vision defect among secondary school students in enugu, Nigeria: prevalence, pattern and impact
Authors: C Eze Gloria , Kizor -Akaraiwe Nkiru , A Chime Amalachukwu , Anajekwu Cosmas C , N Asimadu Ifeoma , E Edoga Chima , Ezegwui Ifeoma R
Published: May 2021

Aim: To determine the prevalence, pattern and impact of colour vision defects among public secondary school students in Enugu, Nigeria with a view to guiding the affected students on appropriate career choice. Methods: A descriptive cross-sectional study was carried out among students attending public secondary schools in Enugu-East Local Government Area, Enugu state. A total of 950 students (361 males, 589 females) were selected by multistage sampling. The students were assessed for colour vision using Ishihara 38 plate edition and Farnsworth D-15 colour caps. An interviewer-administered structured questionnaire was used to obtain the socio-demographic data and impact of colour vision on colour-related school tasks and activities of daily living. Data was analysed using statistical package foe social sciences, version 20. Result: The age of the students ranged from 10-20 years with mean age of 14.2 ± 1.9 years. Eleven (1.2%) students were found to have colour vision defect out of whom 9 were boys and 2 were girls, 6 (54.5%) were deutan and 5 (45.5%) were protan. No tritan defect was detected. Greater percentages of the students with colour vision defect had difficulties with colour-related school tasks and daily activities when compared to those with normal colour vision. Conclusion: Colour vision defect may affect students’ performance in colour-related school tasks and activities of daily living. Therefore, early detection of colour vision defect is important so as to guide in the choice of future career
An atypically distributed fleck case with multiple retinal pigment epithelial detachments
Authors: Cate Sercan , Bektas Caglar , Turgut Burak
Published: May 2021

A 45-year-old female patient presented with complaints of blurred vision and metamorphopsia with a duration of two months. Visual acuities were 0.1 in the right eye and 1.0 in the left eye. Fundus examination revealed bilateral, subretinal, round and yellow-white flecks with scattered localization in the fovea, macula and peripheral retina. Flecks were mostly concentrated in the macula and midperipheral fundus however were rare in the peripheral fundus. In fluorescein angiography, flecks were stained as well-demarcated hyperfluorescent lesions. In optical coherence tomography, there were hump-shaped lesions which have medium degree internal reflectivity at the level of retinal pigment epithelium along with hyporeflective dome-shaped pigment epithelial detachments. No genetic predisposition was found. As a consequence of these findings, the patient was diagnosed with an atypically distributed fleck case with multiple retinal pigment epithelial detachments
Interventions required in food system for better health outcome
Authors: Singh Ruchi
Published: May 2021

Food and agriculture are playing key roles for many of the global challenges such as poverty, under-nutrition, obesity, climate change, and biodiversity loss which impacts the health of the population of the country thus also impacts the economy of both developed and developing countries differently. Many changes are already implemented from food production to consumptions from various sectors but the efforts are still not enough and in infancy. The food system is a complicated network of tasks involving various steps from production, to consumption. The food system includes other factors of sociological factors like governance, the economics of food production, culture, health, sustainability, and its effect on the natural environment. This research paper will propose the primary changes required in the food system, policies, and dietary perspective to construct an integrated methodology of intervention, after evaluating web of interconnected different indicator variable and analyzing the previous methods of intervention responsible for food sustainability directly and indirect, at two different levels local and global. I will address the root cause of a problem in food system which impacts the health which includes various sectors such as socially, economically and politically channel at various levels in the food system to help the United Nations’ Sustainable Development Goals (SDGs). Apart from this, the study also evaluates the economical burden from health issues resulting from the failing food system in developed and developing countries
Treatment of patients with advanced diabetes type 2 and hypertension without the use of conventional treatment is possible: white matter alterations and treatment of diabetes and hypertnsion as a new medical hypothesis
Authors: J Alkhatib Ahed
Published: May 2021

Diabetes has been described for 3500 years. Therapeutic options vary but they involve giving insulin or lowering glucose such as metformin. The objective of this study was to report how diabetes type 2 and hypertension can be treated successfully without using the diabetes conventional treatments. A 50 years male with high glucose level (330 mg/dl), HBA1c (9.6%). Blood profile was altered. Hypertension was elevated (145/100) mm hg. The patient expressed his tension and desire not to commit conventional diabetic and hypertension treatment and asked for other therapeutic alternatives. Based on our experience, we recommended him to use two spoon of ground Urtica pilulifera (U. p)/ day, and to use two capsules of Ammi visnaga (A.V) following each meal. Further, the patient followed the dietary restrictions by replacing white bread with a spoon and followed some exercise programs by walking for 30 minutes a day. The results of this program were shown as continuous lowering blood glucose to the level of 117 mg/dl, and blood pressure was 123/79 after 5 days. Taken together, both diabetes type 2 and hypertension can be successfully treated naturally
Case series: COVID-19 infection causing new-onset diabetes mellitus?
Authors: Katkar Rujuta , Madam Narasa Raju
Published: May 2021

Objectives: This paper seeks to explore the hypothesis of the potential diabetogenic effect of SARS-COV-2 (Severe Acute respiratory syndrome coronavirus). Case series presentation: We present a case series of observation among 8 patients of age group ranging from 34 to 74 years with a BMI range of 26.61 to 53.21 Kilogram/square meters that developed new-onset diabetes after COVID-19 infection. Severe Acute Respiratory Syndrome Coronavirus (SARS-COV-2), commonly known as Coronavirus or COVID-19(Coronavirus infectious disease), gains entry into the cells by binding to the Angiotensin-converting enzyme-2(ACE-2) receptors located in essential metabolic tissues including the pancreas, adipose tissue, small intestine, and kidneys. The evidence reviewed from the scientific literature describes how ACE 2 receptors play a role in the pathogenesis of diabetes and the plausible interaction of SARS-COV-2 with ACE 2 receptors in metabolic organs and tissues. Conclusion: The 8 patients without a past medical history of diabetes admitted with COVID-19 infection developed new-onset diabetes mellitus due to plausible interaction of SARS-COV-2 with ACE 2 receptors. The resulting downregulation of ACE-2 and ACE-2 receptors expression caused islet-cell damage resulting into diabetes. The resulting observation has the potential to adversely impact significant number of the globally affected population. Screening patients with COVID-19 for diabetes routinely can help in early detection, significantly reducing morbidity and mortality associated with diabetes. Due to limitations of observational study with a small sample size will require further investigation in the form of Clinical trial.