bluuebunny/crossref_metadata_2025 huggingface dataset:
Non-magnetic four-port electronic circulators based on $$90^\circ $$ non-reciprocal phase-shifters
Authors: Regev Dror , Regev Shaked , Shilo Shimi , Ezri Doron , Ginzberg Nimrod , Cohen Emanuel
Published: February 2024

This paper presents a family of four-port electronic circulators adhering to a new topology symmetry that enables linear, low-loss transistor-based circuit implementations. The underlying principle of operation employs a property of the$$90^\circ $$90∘non-reciprocal phase shifter (NRPS) derived in this article. Under quadrature excitation, the NRPS transfers or reflects exciting signals depending on their respective phase lead. The fundamental topology consists of two back-to-back quadrature hybrid couplers with a$$90^\circ $$90∘NRPS connected in parallel over the line of symmetry, interrupting the circuit’s reciprocity to achieve circular propagation by bypassing or reflecting at the NRPS but not through. We break down the circuit into three fundamental four-port sub-circuits. The transfer function of the cascaded sub-circuits enables an analysis with specific hybrid couplers. It also allows a synthesis of other four-port passive sub-circuits that, with an NRPS, achieve a four-port circulator transfer function by solving a matrix equation. Some of the mathematical solutions have circuit realizations, which are adjusted quadrature hybrid structures that differ from each other by the characteristic impedance of their arms. Two familiar solutions, including the standard quadrature hybrid and a modified design with equal$$Z_0$$Z0,$$\lambda /4$$λ/4arms, are simulated utilizing lossless lumped element arms and a 4-Path, 65-nm NMOS$$90^\circ $$90∘NRPS. The simulation results verify the theoretical analysis and enable a comparison between the performance of the two circuit solutions around 1 GHz. The four-port circulator with equal arms is implemented on a PCB and measured, yielding better than 1.5 dB insertion loss between the circulator ports, over 17 dB port-to-port reverse isolation, and better than 20 dBr port matching around 1 GHz.
Efficient content caching for 5G assisted vehicular networks
Authors: Ahmed Faareh , Alsamani Badr , Alkhathami Mohammed , Alsadie Deafallah , Alosaimi Norah , Alenzi Badriya , Nkenyereye Lewis
Published: February 2024

Traffic congestion is one of the major challenges faced by daily commuters in smart cities. An autonomous transportation system with a 5 G-based Cellular Vehicle-to-Everything (C-V2X) communication system is the solution to meet the traffic challenges faced in smart cities. Vehicular networks provide wireless connectivity to enable a large number of connected vehicle applications. Vehicular networks allow vehicles to share their emergency and infotainment traffic by following vehicle-to-vehicle (V2V) or by using vehicle-to-infrastructure (V2I) communication. The infrastructure of vehicular networks mainly comprises multiple Road Side Units (RSUs). Fog computing nodes are placed adjacent to these RSUs to provide quick access to vehicles. For infotainment traffic, vehicles intend to download their required content from the content provider. Caching the same contents from the nearby fog computing node significantly reduces delay with improved quality of service. As there are millions of contents with varying sizes, caching all demanded contents on these fog nodes is not possible due to their limited caching capacity. In this work, we propose an improved content caching scheme for fog nodes to satisfy vehicles and content providers for fair content placement. The proposed algorithm is based on a modified Gale–Shapley technique that considers factors such as content popularity, vehicle connectivity, and quality of the communication channel to optimize the content caching process. Simulation results show that the proposed technique caches a higher number of popular contents with lower downloading time.
Circadian characteristics of term and preterm labors
Authors: Moškon Miha , Kovač Urša , Raspor Dall’Olio Lucija , Geršak Ksenija , Kavšek Gorazd , Bojc Šmid Eva , Trojner Bregar Andreja , Rozman Damjana
Published: February 2024

The labor is a physiological event considered to have its own circadian (diurnal) rhythm, but some of the data remain conflicting, especially for preterm births. In this retrospective study, we analyzed the circadian trends of labor onset times in the Slovenian birth cohort from 1990 to 2018 with over 550,000 cases of singleton births. The number of term and preterm labor onsets was calculated for each hour in a day and circadian trends were evaluated for each of the study groups by modeling with a generalized Poisson distribution linked with the cosinor regression model using logarithmic link function. The induced labors were taken as the control group since the timing of labor depends mostly on the working schedule of personnel and not on the intrinsic rhythmic characteristics. For induced labors, the main peak in the number of labor cases was observed in the late morning hours (around 10 AM) for all gestational ages. The prominence of this peak becomes smaller in spontaneous premature labors with gradually disrupting rhythmicity in very preterm and extremely preterm cases. Labors starting with spontaneous contractions peak between 6 and 7 AM and lose the rhythmicity at 35 weeks of gestation while labors starting with a spontaneous rupture of membranes peak at 1 AM and lose the rhythmicity at 31 weeks of gestation, suggesting differences in underlying mechanisms. According to our knowledge, this is the first study that shows differences of circadian trends between different types of spontaneous labors, i.e., labors initiated with contraction and labors initiated with a spontaneous rupture of membranes. Moreover, the obtained results represent evidence of gradual disruption of rhythmicity from mild to extreme prematurity.
Quercetin-crosslinked chitosan nanoparticles: a potential treatment for allergic rhinitis
Authors: Mu Dehong , Zhou Li , Shi Lingyu , Liu Ting , Guo Ying , Chen Hao , Luo Hongping , Ma Junhao , Zhang Hui , Xiong Peizheng , Tian Li
Published: February 2024

Allergic rhinitis (AR) remains a major health problem worldwide. Compared with traditional oral drugs, nasal administration avoids first-pass metabolism and achieve faster and more effective efficacy. In this study, we used the ion crosslinking method to prepare quercetin–chitosan nasal adaptive nanomedicine (QCS) delivery system and evaluated in the treatment of allergic rhinitis mice models. The obtained positively charged nanoparticles with a particle size of 229.2 ± 0.2 nm have excellent characteristics in encapsulation efficiency (79.604%), drug loading rate (14.068%), drug release (673.068 μg) and stability(> 7 days). Excitingly, QCS treatment significantly reduced the number of sneezing and nasal rubbing events in AR mice, while reducing the levels of inflammatory factors such as immunoglobulin E (IgE), interleukin (IL)-17, tumor necrosis factor (TNF)-α, and (IL)-6 to alleviate AR symptoms. Hematoxylin–eosin (HE) staining also showed the damaged nasal mucosa was improved. These experimental results suggest that QCS can effectively suppress allergic inflammation in a mouse model and hold promise as a therapeutic option for allergic rhinitis.
The complete plastome sequences of invasive weed Parthenium hysterophorus: genome organization, evolutionary significance, structural features, and comparative analysis
Authors: Lubna  , Asaf Sajjad , Jan Rahmatullah , Asif Saleem , Bilal Saqib , Khan Abdul Latif , Al-Rawahi Ahmed N. , Kim Kyung-Min , AL-Harrasi Ahmed
Published: February 2024

Parthenium hysterophorus, a globally widespread weed, poses a significant threat to agricultural ecosystems due to its invasive nature. We investigated the chloroplast genome of P. hysterophorus in this study. Our analysis revealed that the chloroplast genome of P. hysterophorus spans a length of 151,881 base pairs (bp). It exhibits typical quadripartite structure commonly found in chloroplast genomes, including inverted repeat regions (IR) of 25,085 bp, a small single copy (SSC) region of 18,052 bp, and a large single copy (LSC) region of 83,588 bp. A total of 129 unique genes were identified in P. hysterophorus chloroplast genomes, including 85 protein-coding genes, 36 tRNAs, and eight rRNAs genes. Comparative analysis of the P. hysterophorus plastome with those of related species from the tribe Heliantheae revealed both conserved structures and intriguing variations. While many structural elements were shared among the species, we identified a rearrangement in the large single-copy region of P. hysterophorus. Moreover, our study highlighted notable gene divergence in several specific genes, namely matK, ndhF, clpP, rps16, ndhA, rps3, and ndhD. Phylogenetic analysis based on the 72 shared genes placed P. hysterophorus in a distinct clade alongside another species, P. argentatum. Additionally, the estimated divergence time between the Parthenium genus and Helianthus (sunflowers) was approximately 15.1 million years ago (Mya). These findings provide valuable insights into the evolutionary history and genetic relationships of P. hysterophorus, shedding light on its divergence and adaptation over time.
Antigenicity and immunogenicity of different morphological forms of Borrelia burgdorferi sensu lato spirochetes
Authors: Sloupenska Kristyna , Koubkova Barbora , Horak Pavel , Dolezilkova Jana , Hutyrova Beata , Racansky Mojmir , Miklusova Martina , Mares Jan , Raska Milan , Krupka Michal
Published: February 2024

Borrelia burgdorferi sensu lato is a species complex of pleomorphic spirochetes, including species that cause Lyme disease (LD) in humans. In addition to classic spiral forms, these bacteria are capable of creating morphological forms referred to as round bodies and aggregates. The subject of discussion is their possible contribution to the persistence of infection or post-infection symptoms in LD. This study investigates the immunological properties of these forms by monitoring reactivity with early (n = 30) and late stage (n = 30) LD patient sera and evaluating the immune response induced by vaccination of mice. In patient sera, we found a quantitative difference in reactivity with individual morphotypes, when aggregates were recognized most intensively, but the difference was statistically significant in only half of the tested strains. In post-vaccination mouse sera, we observed a statistically significant higher reactivity with antigens p83 and p25 (OspC) in mice vaccinated with aggregates compared to mice vaccinated with spiral forms. The importance of the particulate nature of the antigen for the induction of a Th1-directed response has also been demonstrated. In any of morphological forms, the possibility of inducing antibodies cross-reacting with human nuclear and myositis specific/associated autoantigens was not confirmed by vaccination of mice.
Impact of the diet in the gut microbiota after an inter-species microbial transplantation in fish
Authors: Ruiz Alberto , Gisbert Enric , Andree Karl B.
Published: February 2024

Inter-species microbial transplantations offer the possibility of transferring species-specific microbes and their associated functionality. As a conceptual approach, an intestinal microbiota transplant (IMT) between two marine carnivorous fish species that thrive in different environmental conditions was conducted: from donor Atlantic salmon (Salmo salar) to recipient gilthead seabream (Sparus aurata), after obliterating its basal microbiota with an antibiotic treatment. To confirm that the gut microbiota was able to recover after antibiotics without the influence of the diet, a group of gilthead seabream not submitted to the IMT was kept fasted as an internal control. To assess the effect of the diet after the IMT, two groups of gilthead seabream were respectively fed with their typical diet and with Atlantic salmon diet. At 36 days post-IMT, the gut of the individuals fed with their typical diet was dominated by the feed-associated bacteria, while those fed with the salmon diet had developed a unique microbiota from the convergence of the diet, donor, and recipient microbiota. These results suggested that an intestinal microbiota transplantation may be effective if the basal microbiota from the gut is first cleared and a targeted dietary modification is provided to maintain and enrich the novel bacteria species over time.
Multi-omics resources for the Australian southern stuttering frog (Mixophyes australis) reveal assorted antimicrobial peptides
Authors: Tang Simon , Peel Emma , Belov Katherine , Hogg Carolyn J. , Farquharson Katherine A.
Published: February 2024

The number of genome-level resources for non-model species continues to rapidly expand. However, frog species remain underrepresented, with up to 90% of frog genera having no genomic or transcriptomic data. Here, we assemble the first genomic and transcriptomic resources for the recently described southern stuttering frog (Mixophyes australis). The southern stuttering frog is ground-dwelling, inhabiting naturally vegetated riverbanks in south-eastern Australia. Using PacBio HiFi long-read sequencing and Hi-C scaffolding, we generated a high-quality genome assembly, with a scaffold N50 of 369.3 Mb and 95.1% of the genome contained in twelve scaffolds. Using this assembly, we identified the mitochondrial genome, and assembled six tissue-specific transcriptomes. We also bioinformatically characterised novel sequences of two families of antimicrobial peptides (AMPs) in the southern stuttering frog, the cathelicidins and β-defensins. While traditional peptidomic approaches to peptide discovery have typically identified one or two AMPs in a frog species from skin secretions, our bioinformatic approach discovered 12 cathelicidins and two β-defensins that were expressed in a range of tissues. We investigated the novelty of the peptides and found diverse predicted activities. Our bioinformatic approach highlights the benefits of multi-omics resources in peptide discovery and contributes valuable genomic resources in an under-represented taxon.
Assessment of area and structural irregularity of retinal layers in diabetic retinopathy using machine learning and image processing techniques
Authors: Riazi-Esfahani Hamid , Jafari Behzad , Azimi Hossein , Rahimi Masoud , Saeidian Jamshid , Pouya Parnia , Faghihi Hooshang , Mirzaei Arash , Asadi Khameneh Esmaeil , Khalili Pour Elias
Published: February 2024

Diabetes retinopathy prevention necessitates early detection, monitoring, and treatment. Non-invasive optical coherence tomography (OCT) shows structural changes in the retinal layer. OCT image evaluation necessitates retinal layer segmentation. The ability of our automated retinal layer segmentation to distinguish between normal, non-proliferative (NPDR), and proliferative diabetic retinopathy (PDR) was investigated in this study using quantifiable biomarkers such as retina layer smoothness index (SI) and area (S) in horizontal and vertical OCT images for each zone (fovea, superior, inferior, nasal, and temporal). This research includes 84 eyes from 57 individuals. The study shows a significant difference in the Area (S) of inner nuclear layer (INL) and outer nuclear layer (ONL) in the horizontal foveal zone across the three groups (p < 0.001). In the horizontal scan, there is a significant difference in the smoothness index (SI) of the inner plexiform layer (IPL) and the upper border of the outer plexiform layer (OPL) among three groups (p < 0.05). There is also a significant difference in the area (S) of the OPL in the foveal zone among the three groups (p = 0.003). The area (S) of the INL in the foveal region of horizontal slabs performed best for distinguishing diabetic patients (NPDR and PDR) from normal individuals, with an accuracy of 87.6%. The smoothness index (SI) of IPL in the nasal zone of horizontal foveal slabs was the most accurate at 97.2% in distinguishing PDR from NPDR. The smoothness index of the top border of the OPL in the nasal zone of horizontal slabs was 84.1% accurate in distinguishing NPDR from PDR. Smoothness index of IPL in the temporal zone of horizontal slabs was 89.8% accurate in identifying NPDR from PDR patients. In conclusion, optical coherence tomography can assess the smoothness index and irregularity of the inner and outer plexiform layers, particularly in the nasal and temporal regions of horizontal foveal slabs, to distinguish non-proliferative from proliferative diabetic retinopathy. The evolution of diabetic retinopathy throughout severity levels and its effects on retinal layer irregularity need more study.
A systematic review and meta-analysis of the effects of long-term antibiotic use on cognitive outcomes
Authors: Ye Yongqin , Tong Hor Yee Kimberley , Chong Wai Hong , Li Zhiqian , Tam Paul Kwong Hang , Baptista-Hon Daniel T. , Monteiro Olivia
Published: February 2024

Antibiotics are indispensable to infection management. However, use of antibiotics can cause gut microbiota dysbiosis, which has been linked to cognitive impairment by disrupting communication between the gut microbiota and the brain. We conducted a systematic review and meta-analysis on the effects of long-term antibiotic use on cognitive outcomes. We have searched PubMed, Web of Science, Embase, Cochrane Library and Scopus for English publications before March 2023 following the PRISMA guidelines. Screening, data extraction, and quality assessment were performed in duplicate. 960 articles were screened and 16 studies which evaluated the effect of any antibiotic compared to no antibiotics or placebo were included. Case-reports, in vitro and animal studies were excluded. We found that antibiotic use was associated with worse cognitive outcomes with a pooled effect estimate of − 0.11 (95% CI − 0.15, − 0.07, Z = 5.45; P < 0.00001). Subgroup analyses performed on adult vs pediatric patients showed a similar association of antibiotic on cognition in both subgroups. Antibiotic treatment was not associated with worse cognition on subjects with existing cognitive impairment. On the other hand, antibiotic treatment on subjects with no prior cognitive impairment was associated with worse cognitive performance later in life. This calls for future well-designed and well-powered studies to investigate the impact of antibiotics on cognitive performance.
Identification of hub genes and transcription factors in patients with primary gout complicated with atherosclerosis
Authors: Xiao Lu , Lin Shudian , Zhan Feng
Published: February 2024

Evidence shows that primary gout is prone to develop to atherosclerosis, but the mechanism of its occurrence is still not fully clarified. The aim of this study was to explore the molecular mechanism of the occurrence of this complication in gout. The gene expression profiles of primary gout and atherosclerosis were downloaded from the gene expression omnibus database. Overlapping differentially expressed genes (DEGs) between gout and atherosclerosis were identified. The biological roles of common DEGs were explored through enrichment analyses. Hub genes were identified using protein–protein interaction networks. The immune infiltrations of 28 types of immune cells in gout and control samples from GSE160170 were evaluated by the ssGSEA method. Transcription factors (TFs) were predicted using Transcriptional Regulatory Relationships Unraveled by Sentence Based Text Mining (TRRUST) database. A total of 168 overlapping DEGs were identified. Functional enrichment analyses indicated that DEGs were mostly enriched in chemokine signaling pathway, regulation of actin cytoskeleton, and TNF signaling pathway. CytoScape demonstrated 11 hub genes and two gene cluster modules. The immune infiltration analysis showed that the expression of DEGs in gout was significantly upregulated in activated CD4 T cells, gamma delta T cells, T follicular helper cell, CD56dim natural killer cells, and eosinophil. TRRUST predicted one TF, RUNX family transcription factor 1. Our study explored the pathogenesis of gout with atherosclerosis and discovered the immune infiltration of gout. These results may guide future experimental research and clinical transformation.
Impact of nonspecific allograft biopsy findings in symptomatic kidney transplant recipients
Authors: Koo Bon Jin , Huh Hyuk , Ye Byung Min , Kim Yunmi , Choi Byung Hyun , Lee Hyun Jeong , Kang Mi Seon , Lee Dong Won , Lee Soo Bong , Kim Yeong Hoon , Kim Il Young , Kim Taehee , Kim Seo Rin
Published: February 2024

A for-cause biopsy is performed to diagnose the cause of allograft dysfunction in kidney transplantation. We occasionally encounter ambiguous biopsy results in symptomatic kidney transplant recipients. Yet, the allograft survival outcome in symptomatic recipients with nonspecific allograft biopsy findings remains unclear. The purpose of this study was to analyze the impact of nonspecific for-cause biopsy findings in symptomatic kidney transplant recipients. We retrospectively collected records from 773 kidney transplant recipients between January 2008 and October 2021. The characteristics of transplant recipients with nonspecific findings in the first for-cause biopsy were analyzed. Nonspecific allograft biopsy findings were defined as other biopsy findings excluding rejection, borderline rejection, calcineurin inhibitor toxicity, infection, glomerulonephritis, and diabetic nephropathy. The graft outcome was compared between recipients who had never undergone a for-cause biopsy and those who had a first for-cause biopsy with nonspecific findings. The graft survival in recipients with nonspecific for-cause biopsy findings was comparable to that in recipients who did not require the for-cause biopsy before and after propensity score matching. Even in symptomatic kidney transplant recipients, nonspecific allograft biopsy findings might not be a poor prognostic factor for allograft survival compared to recipients who did not require the for-cause biopsy.
A retrospective observational study of 1000 consecutive patients tested with the FilmArray® Meningitis/Encephalitis panel: clinical diagnosis at discharge and microbiological findings
Authors: Sunnerhagen Torgny , Widén Johan , Handhal Sahar , Özkaya Şahin Gülşen
Published: February 2024

FilmArray® Meningitis/Encephalitis panel (FAME-p) is used to diagnose central nervous system (CNS) infections. In this study, we investigated performance of FAME-p compared to comparator assays (CA), and for the first time, clinical diagnosis at discharge (CDD). 1000 consecutive patients with a cerebrospinal fluid (CSF) sample analyzed with FAME-p were identified. As CA, culture, polymerase chain reaction and cryptococcal antigen test were used. Medical records of patients were obtained. A CDD of CNS infection was made in 139 of 1000 CSF samples. FAME-p was positive in 66 samples with 44 viral and 22 bacterial agents. Thirteen FAME-p findings were not confirmed by CA, with four discrepant results remaining after comparison with the CDD. Positive percentage agreement (PPA) calculated against CA was 100%. Negative percentage agreement (NPA) calculated against CA was 94.4–99.8% for Haemophilus influenzae, Listeria monocytogenes, Streptococcus agalactiae, S. pneumoniae and varicella-zoster virus (VZV). NPA calculated against CDD was higher (compared to CA) for L. monocytogenes, S. agalactiae and VZV (100%), and lower for Escherichia coli, enterovirus and herpes simplex virus 2 (50–83.3%). NPA of FAME-p for human herpes virus 6 was difficult to interpret. Eighty-four cases received diagnosis of CNS-infection despite negative FAME-p. The four most common non-infectious etiologies were primary headache disorders, cranial nerve palsies, neuroinflammatory disorders and seizure. Although FAME-p shows good performance in diagnosis of CNS infections, result of FAME-p should be interpreted carefully. Considering infectious diseases not covered by FAME-p as well as non-infectious differential diagnoses is important in this context.
Association between the surgical approach and prognosis of spontaneous supratentorial deep intracerebral hemorrhage
Authors: Shi Hui , Tan Xingwei , Deng Yongbing , He Minglian , Chen Dongsheng , Zhou Weichong , Tang Xiaoyong , Liu Yang , Cui Min
Published: February 2024

The association between surgical approach and prognosis in patients with spontaneous supratentorial deep intracerebral hemorrhage is unclear. We aimed to explore the association between surgical approach and prognosis in these patients. A retrospective cohort of 311 patients from 3 centers who were treated with surgery 24 h after ictus was recruited. The surgical procedure involved removing the intracerebral hematoma using an aspirator through either the cortical approach or Sylvian fissure approach, assisted by an endoscope or microscope. The primary outcome was the one-year modified Rankin scale (mRS) score. The association between the surgical approach and the one-year mRS score was explored by using ordinal logistic regression and binary logistic regression. Baseline characteristics were balanced by propensity score matching and inverse propensity score weighting. In the adjusted analysis, compared with the cortex approach group, the Sylvian fissure approach group had better one-year mRS scores when analyzed as an ordinal variable (3.00 [2.00–4.00] vs. 4.00 [3.00–5.00]; adjusted odds ratio, 3.15; 95% CI, 1.78–5.58; p < 0.001) and a dichotomous variable (74.14% vs. 49.01%; adjusted odds ratio, 6.61; 95% CI, 2.75–15.88; p < 0.001). Surgical approach was not significantly associated with rebleeding (p = 0.88) or three-month mortality (p = 0.81). In univariate analysis after propensity score matching, there were significant differences in one-year mRS score between the two groups (p < 0.001), and there were no significant differences in rebleeding (Fisher’s exact test, p > 0.999) or three-month mortality (Fisher's exact test, p > 0.999). Inverse probability weighted regression analysis showed better one-year mRS scores when analyzed as an ordinal variable (adjusted odds ratio, 3.03; 95% CI, 2.17–4.17; p < 0.001) and a dichotomous variable (adjusted odds ratio, 3.11; 95% CI, 2.16–4.77; p < 0.001) in the Sylvian fissure approach group; the surgical approach was not significantly associated with rebleeding (p = 0.50) or three-month mortality (p = 0.60). In the surgical treatment of patients with spontaneous supratentorial deep intracerebral hemorrhage, the Sylvian fissure approach may lead to a better functional outcome compared with the cortex approach. Future prospective studies are warranted to confirm this finding.
Transductive meta-learning with enhanced feature ensemble for few-shot semantic segmentation
Authors: Karimi Amin , Poullis Charalambos
Published: February 2024

This paper addresses few-shot semantic segmentation and proposes a novel transductive end-to-end method that overcomes three key problems affecting performance. First, we present a novel ensemble of visual features learned from pretrained classification and semantic segmentation networks with the same architecture. Our approach leverages the varying discriminative power of these networks, resulting in rich and diverse visual features that are more informative than a pretrained classification backbone that is not optimized for dense pixel-wise classification tasks used in most state-of-the-art methods. Secondly, the pretrained semantic segmentation network serves as a base class extractor, which effectively mitigates false positives that occur during inference time and are caused by base objects other than the object of interest. Thirdly, a two-step segmentation approach using transductive meta-learning is presented to address the episodes with poor similarity between the support and query images. The proposed transductive meta-learning method addresses the prediction by first learning the relationship between labeled and unlabeled data points with matching support foreground to query features (intra-class similarity) and then applying this knowledge to predict on the unlabeled query image (intra-object similarity), which simultaneously learns propagation and false positive suppression. To evaluate our method, we performed experiments on benchmark datasets, and the results demonstrate significant improvement with minimal trainable parameters of 2.98M. Specifically, using Resnet-101, we achieve state-of-the-art performance for both 1-shot and 5-shot Pascal-$$5^{i}$$

5
i

, as well as for 1-shot and 5-shot COCO-$$20^{i}$$

20
i

.
Household food insecurity and associated factors among postpartum women in southern Ethiopia: a community based cross sectional study
Authors: Dinagde Dagne Deresa , Wada Habtamu Wana , Chewaka Menen Tilahun
Published: February 2024

Approximately two billion individuals, or 26.4% of the global population, live in moderate- to severely food-insecure circumstances. It was discovered that not receiving all recommended antenatal care throughout one's pregnancy is one of the effects of household insecurity. The majority of women in Ethiopia, one of the most food-insecure countries in the world, with 10% of the population facing food poverty, devote more of their time to household duties, making food insecurity in the home the primary effect of poor prenatal care utilization. The main objective this study was to assess the status of household food insecurity among postpartum women at Arba Minch town, southern Ethiopia. A community-based cross-sectional study was conducted among 381 mothers who were enrolled from December 1, 2022, to January 30, 2023. The total sample size was allocated proportionately to the number of postpartum women living in each kebeles taking from the town registry of health extension workers for immunization. Thus, systematic sampling was applied. Kobo Toolbox was used for data collection and cleaning, which was then analyzed using the statistical package of Social Science Version 26 (SPSS). In this study, the prevalence of food insecurity was 30.2% (95% CI 25.5–34.5). The associated factors with household food-insecurity were maternal occupation (AOR = 0.5, 95% CI 0.27, 0.90), late antenatal care initiation (AOR = 3.5, 95% CI 2.13, 5.91), and low monthly income (AOR = 3.1, 95% CI 1.38, 6.93). Food insecurity among postpartum mothers in the study area is high. Families who are severely food insecure require quick assistance to lower poor maternal and neonate’s outcomes. Furthermore, enhancing the occupation of mothers is crucial in reducing the morbidities and mortality of food insecure mothers, such as delayed prenatal care services, anemia, low birth weight, and stillbirth.
The potential influence of the ligament of Wieger on the crystalline lens shape
Authors: Ghaderi Hosna , Ní Dhubhghaill Sorcha , Tassignon Marie-José , Van Os Luc , Koppen Carina , Rozema Jos J.
Published: February 2024

This research uses mathematical modelling to evaluate the influence of the ligament of Wieger on the crystalline lens shape at rest, and during accommodation. An axisymmetric model of the anterior segment, including the ligament of Wieger, was created using the finite element method. Different conditions including variations of stiffness and positions of the ligament, with and without the ligament, were tested to see how they affected lens curvature and optical power. Adding the ligament of Wieger to the simulation had a noticeable impact on the optical power of the lens, particularly on the posterior surface power and total power. Ligament stiffness and width significant influenced the accommodative range of the eye by − 0.95D and − 2.39D for ligaments with the same and 3× the stiffness of the capsular bag, respectively. Ligament width and inner diameter had negligible effects on lens thickness but did have significant effects on posterior surface power and accommodation. In this simulation, we found that the ligament of Wieger can significantly affect the lens shape, both at rest and during accommodation, and may need to be considered in lens models.
Regression-based Chinese norms of number connection test A and digit symbol test for diagnosing minimal hepatic encephalopathy
Authors: Zhang Peng , Gan Danan , Chi Xiaoling , Mao Dewen , Gao Yueqiu , Li Yong , Zhou Daqiao , Li Qin , Zhang Mingxiang , Lu Bingjiu , Li Fengyi , Xue Jingdong , Wang Xianbo , Du Hongbo , Li Xiaoke , Liang Yijun , Ye Yongan
Published: February 2024

Number connection test A (NCT-A) and digit symbol test (DST), the preferential neuropsychological tests to detect minimal hepatic encephalopathy (MHE) in China, haven’t been standardized in Chinese population. We aimed to establish the norms based on a multi-center cross-sectional study and to detect MHE in cirrhotic patients. NCT-A and DST were administered to 648 healthy controls and 1665 cirrhotic patients. The regression-based procedure was applied to develop demographically adjusted norms for NCT-A and DST based on healthy controls. Age, gender, education, and age by education interaction were all predictors of DST, while age, gender, and education by gender interaction were predictors of log10 NCT-A. The predictive equations for expected scores of NCT-A and DST were established, and Z-scores were calculated. The norm for NCT-A was set as Z ≤ 1.64, while the norm for DST was set as Z ≥ − 1.64. Cirrhotic patients with concurrent abnormal NCT-A and DST results were diagnosed with MHE. The prevalence of MHE was 8.89% in cirrhotic patients, and only worse Child–Pugh classification (P = 0.002, OR = 2.389) was demonstrated to be the risk factor for MHE. The regression-based normative data of NCT-A and DST have been developed to detect MHE in China. A significant proportion of Chinese cirrhotic patients suffered from MHE, especially those with worse Child–Pugh classification.
Inverse association of serum albumin levels with diabetic retinopathy in type 2 diabetic patients: a cross-sectional study
Authors: Li Xianhua , Hao Wenqing , Yang Nailong
Published: February 2024

This study aimed to explore the association between serum albumin (ALB) levels and diabetic retinopathy in patients with type 2 diabetes. In this cross-sectional study, we retrospectively collected clinical data from patients with type 2 diabetes who were admitted to the Endocrinology Department of the Affiliated Hospital of Qingdao University between January 1, 2021, and December 1, 2022. All included patients underwent measurements of serum albumin levels and screening for diabetes-related complications. The association between serum albumin levels and retinopathy was assessed using logistic regression after adjusting for potential confounders. Further, stratified analyses and curve fitting were conducted to delve deeper into the relationship. After inclusion and exclusion criteria were applied, a total of 1947 patients were analyzed. Among these, 982 were male and 965 were female. The mean serum albumin level was 39.86 ± 3.27 g/L. Diabetic retinopathy was present in 41.24% of the patients. After adjusting for potential confounders, we observed a significant inverse association between serum albumin levels and the incidence of retinopathy. Specifically, for every 10 g/L increase in albumin level, the odds of retinopathy decreased (odds ratio [OR] = 0.67; 95% confidence interval [CI] = 0.48–0.94; P = 0.0209).The curve fitting validated the inverse relationship between serum albumin and retinopathy without evidence of non-linearity or threshold saturation effects. Stratified analyses consistently indicated no interaction effects across subgroups. This cross-sectional study identified a significant inverse relationship between serum albumin levels and diabetic retinopathy in patients with type 2 diabetes. However, due to the cross-sectional nature of this study, further prospective studies are warranted to confirm these findings.
Inhibition of LATS kinases reduces tumorigenicity and increases the sensitivity of human chronic myelogenous leukemia cells to imatinib
Authors: Klaihmon Phatchanat , Lorthongpanich Chanchao , Kheolamai Pakpoom , Saisaard Wannachai , Issaragrisil Surapol
Published: February 2024

Chronic myelogenous leukemia (CML) is a clonal hematologic malignancy of the myeloid lineage caused by the oncogenic BCR/ABL fusion protein that promotes CML cell proliferation and protects them against drug-induced apoptosis. In this study, we determine LATS1 and LATS2 expression in CML cells derived from patients who are resistant to imatinib (IM) treatment. Significant upregulation of LATS1 and LATS2 was found in these CML patients compared to healthy donors. To further explore whether the expression of LATS1/2 contributes to the IM-resistant phenotype, IM-resistant CML cell lines generated by culturing CML-derived erythroblastic K562 cells in increasing concentrations of IM were used as in vitro models. Up-regulation of LATS1 and LATS2 was observed in IM-resistant K562 cells. Reduction of LATS using either Lats-IN-1 (TRULI), a specific LATS inhibitor, or shRNA targeting LATS1/2 significantly reduced clonogenicity, increased apoptosis and induced differentiation of K562 cells to late-stage erythroid cells. Furthermore, depletion of LATS1 and LATS2 also increased the sensitivity of K562 cells to IM. Taken together, our results suggest that LATS could be one of the key factors contributing to the rapid proliferation, reduced apoptosis, and IM resistance of CML cells. Targeting LATS could be a promising treatment to enhance the therapeutic effect of a conventional BCR/ABL tyrosine kinase inhibitor such as IM.
Two decades of research on ocean multi-use: achievements, challenges and the need for transdisciplinarity
Authors: Guyot-Téphany Josselin , Trouillet Brice , Diederichsen Sereno , Juell-Skielse Elea , Thomas Jean-Baptiste E , McCann Jennifer , Rebours Céline , Scherer Marinez , Freeman Peter , Gröndahl Fredrik , Walsh John Patrick , Lukic Ivana
Published: February 2024

This paper offers a comprehensive, analytical, and critically informed overview of the current state of ocean multi-use research. It delves into the origins, trajectory, and driving forces behind this emerging research field, all within the broader context of investigations addressing the management of increasingly diverse and intensifying activities at sea. The Bibliometrix R package is employed to analyze the social, geographical, and conceptual dimensions of multi-use scientific production. The results obtained are then compared to a larger corpus of publications focusing on both multiple-use Marine Protected Areas (MPAs) and Marine Spatial Planning (MSP). Finally, the paper addresses research gaps, with a particular emphasis on the transdisciplinary challenges associated with translating this new marine policy concept into practical implementation and extending its application beyond European seas.
Mechanism of ammonium bisulfate deposition on V1M5/Ti catalysts with synergistic effects of V and M (M = Ce, Co, Fe, and Mn) in low-temperature NH3-SCR
Authors: Xu Zhicheng , Xiong Jin , Li Yuran , Guo Junxiang , Wang Bin , Zhu Tingyu
Published: February 2024

Two pathways of ammonium sulfate deposition on V1M5/Ti are elucidated in detail. The synergistic effect of V sites and transitional metal sites reflects in the selective adsorption and competitive oxidation of SO2.
A capacitive mismatch calibration method for SAR ADCs based on TDC
Authors: Shen Qing , Wang Xin , Jiang Mei , Chen Junxian , He Xinhui , Zhou Huanhuan
Published: February 2024

The capacitance mismatch problem limits the accuracy improvement of high‐precision SAR ADCs (Successive Approximation Register Analog‐to‐Digital Converters). To address the capacitance array mismatch in SAR ADCs, this paper proposes a novel capacitor calibration scheme based on the Time‐to‐Digital Converter (TDC). This scheme achieves calibration accuracy as high as 0.01% and can be flexibly designed to meet the accuracy requirements of SAR ADCs. Simulation results indicate that the capacitance mismatch issue of a redundant capacitor 13‐bit SAR ADC can be completely eliminated, and the effective number of bits (ENOB) approach the ideal value of 13.18 bits. Additionally, the analog component of this scheme utilizes four inverter chains, two D flip‐flops, and four counters, without requiring a large area for auxiliary calibration capacitors.
FSKT‐GE: Feature maps similarity knowledge transfer for low‐resolution gaze estimation
Authors: Yan Chao , Pan Weiguo , Dai Songyin , Xu Bingxin , Xu Cheng , Liu Hongzhe , Li Xuewei
Published: February 2024

The limited of texture details information in low‐resolution facial or eye images presents a challenge for gaze estimation. To address this, FSKT‐GE (feature maps similarity knowledge transfer for low‐resolution gaze estimation) is proposed, a gaze estimation framework consisting of both a high resolution (HR) network and low resolution (LR) network with the identical structure. Rather than mere feature imitation, this issue is addressed by assessing the cosine similarity of feature layers, emphasizing the distribution similarity between the HR and LR networks. This enables the LR network to acquire richer knowledge. This framework utilizes a combination loss function, incorporating cosine similarity measurement, soft loss based on probability distribution difference and gaze direction output, along with a hard loss from the LR network output layer. This approach on low‐resolution datasets derived from Gaze360 and RT‐Gene datasets is validated, demonstrating excellent performance in low‐resolution gaze estimation. Evaluations on low‐resolution images obtained through 2×, 4×, and 8× down‐sampling are conducted on two datasets. On the Gaze360 dataset, the lowest mean angular errors of 10.97°, 11.22°, and 13.61° were achieved, while on the RT‐Gene dataset, the lowest mean angular errors of 6.73°, 6.83°, and 7.75° were obtained.
Smart performance optimization of energy‐aware scheduling model for resource sharing in 5G green communication systems
Authors: Sangeetha Sivakumar , Logeshwaran Jaganathan , Faheem Muhammad , Kannadasan Raju , Sundararaju Suganthi , Vijayaraja Loganathan
Published: February 2024

This paper presents an analysis of the performance of the Energy Aware Scheduling Algorithm (EASA) in a 5G green communication system. 5G green communication systems rely on EASA to manage resource sharing. The aim of the proposed model is to improve the efficiency and energy consumption of resource sharing in 5G green communication systems. The main objective is to address the challenges of achieving optimal resource utilization and minimizing energy consumption in these systems. To achieve this goal, the study proposes a novel energy‐aware scheduling model that takes into consideration the specific characteristics of 5G green communication systems. This model incorporates intelligent techniques for optimizing resource allocation and scheduling decisions, while also considering energy consumption constraints. The methodology used involves a combination of mathematical analysis and simulation studies. The mathematical analysis is used to formulate the optimization problem and design the scheduling model, while the simulations are used to evaluate its performance in various scenarios. The proposed EASM reached a 91.58% false discovery rate, a 64.33% false omission rate, a 90.62% prevalence threshold, and a 91.23% critical success index. The results demonstrate the effectiveness of the proposed model in terms of reducing energy consumption while maintaining a high level of resource utilization.
Clinical Case and Literature Review of a Potentially Life-Threatening Complication Derived from Mouth Floor Hematoma after Implant Surgery
Authors: Carreira-Nestares Beatriz , Urquiza-Fornovi Irene , Carreira-Delgado Manuel Carlos , Gutierrez-Díaz Ramón , Sánchez-Aniceto Gregorio
Published: February 2024

The placement of dental implants is a safe and predictable procedure when performed by qualified staff. The incidence of complications derived from this type of surgery has increased due to the greater number of patients undergoing dental rehabilitation treatments in recent years. Floor of the mouth hematoma is a rare, but potentially fatal, complication that every oral surgeon should recognize for early diagnosis. As part of the clinical case presented here, two implants were removed and a hemorrhage in the floor of the mouth was found, which required an urgent intervention to control the bleeding. Two independent researchers conducted an electronic search of the available scientific evidence in relation to bleeding of the floor of the mouth in dental implant surgery. The research included references, which were written in English or Spanish, and published up to December 2022. Case reports, case series, systematic reviews, and meta-analysis were part of the inclusion criteria. Sixty-four bibliographic references were identified, and 39 full-text articles were selected. There were 30 cases of floor of the mouth hematoma in relation to implant surgery. In 13 patients the main location was interforaminal, in 5 in the canine area, in 6 in the incisor area, and in 6 in the molar premolar region. All cases were caused by perforation of the cortical bone or surgical manipulation (disruption of the periosteum, perforation of the sublingual mucosa by the stiff suture). The sublingual artery was most frequently involved. The clinical sign observed in all cases was elevation of the floor of the mouth. In 21 of the cases there was airway involvement, so the main treatment was intubation or tracheostomy. Floor of the mouth hematoma may be one complication associated with implant surgery. Given the seriousness of this clinical picture, early detection by the dentist and hospital referral are essential. Warning signs are sudden swelling of the floor of the mouth or submandibular area, accompanied by dysphagia and dyspnea.
Perioperative Opioid-Related Harms: Opportunities to Minimize Risk
Authors: Alessio-Bilowus Dominic , Luby Alexandra O. , Cooley Samantha , Evilsizer Sarah , Seese Elizabeth , Bicket Mark , Waljee Jennifer F.
Published: February 2024

Although substantial attention has been given to opioid prescribing in the United States, opioid-related mortality continues to climb due to the rising incidence and prevalence of opioid use disorder. Perioperative care has an important role in the consideration of opioid prescribing and the care of individuals at risk for poor postoperative pain- and opioid-related outcomes. Opioids are effective for acute pain management and commonly prescribed for postoperative pain. However, failure to align prescribing with patient need can result in overprescribing and exacerbate the flow of unused opioids into communities. Conversely, underprescribing can result in the undertreatment of pain, complicating recovery and impairing well-being after surgery. Optimizing pain management can be particularly challenging for individuals who are previously exposed to opioids or have critical risk factors, including opioid use disorder. In this review, we will explore the role of perioperative care in the broader context of the opioid epidemic in the United States, and provide considerations for a multidisciplinary, comprehensive approach to perioperative pain management and optimal opioid stewardship.