bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Tool Rotation Speed on Mechanical Properties of Friction Stir Spot Welded (FSSW) AA7075-T6 Aluminium Alloy Sheets
Authors: UĞURLU Mustafa , ÇAKAN Ahmet
Published: October 2019

In this study, the effect of tool rotation speed on the mechanical and
metallurgical properties of friction stir spot welded (FSSW) AA 7075-T6
aluminum alloy plates was investigated. Aluminum alloy plates were joined by FSSW
using welding parameters consisting of three different rotation speeds of 1040,
1320 and 1500 rpm and a constant insertion depth of 3.2 mm. In spot welded specimens,
the highest tensile strength value (6200 N) was obtained in plates welded at a tool
rotation speed of 1500 rpm. The data obtained from the metallographic analysis
are compatible with the tensile test results. Metallographic investigations
demonstrated that there was a small amount of porosity in the welding zone of
the specimens jointed at 1500 rpm.
Erupción polimorfa del embarazo, un diagnóstico diferencial de las reacciones graves por medicamentos
Authors: Calle Ana , Guevara-Saldaña Liliana , Cardona Ricardo
Published: October 2019

Antecedentes: La erupción polimorfa del embarazo es una patología que se presenta normalmente en el último trimestre de los embarazos y afecta aproximadamente a 0.5 % de las mujeres en esta condición. No se ha relacionado con medicamentos, pero podría imitar cualquier reacción grave por medicamentos tardías.Caso clínico: Mujer con cuadro clínico sugestivo de erupción polimorfa del mbarazo durante el último trimestre del embarazo. Fue valorada por alergología, donde se consideró erupción polimorfa del embarazo, sin embargo, se decidió realizar pruebas cutáneas: punción cutánea, pruebas intradérmicas y prueba de parche con medicamentos implicados, todas con resultados negativos.Conclusiones: Las reacciones graves por medicamentos son un reto para el profesional de la salud. En el manejo agudo, la identificación y suspensión del medicamento implicado son la piedra angular del tratamiento, sin embargo, numerosas pacientes están polimedicadas, lo que dificulta identificar la causa subyacente. Es recomendable una valoración por alergología como parte del manejo multidisciplinario óptimo de cada paciente, con el fin de lograr detectar la sustancia implicada como causal de la enfermedad y evitar restricciones innecesarias.
Hipoplasia cartílago-cabello. Reporte de un caso
Authors: Staines-Boones Tamara Aidé , González-Villarreal María Guadalupe , Hernández-Fernández Cecilia
Published: October 2019

Antecedentes: La hipoplasia cartílago-cabello es una enfermedad autosómica recesiva poco frecuente, caracterizada por condrodisplasia metafisaria y cabello fino. Puede estar acompañada de alteraciones inmunológicas en distintos grados.Caso clínico: Niña de 35 meses de edad, quien desde su nacimiento mostró restricción del crecimiento; desarrolló 11 cuadros de neumonías, síndrome de malabsorción y megacolon agangliónico, por lo que se diagnosticó hipoplasia cartílago-cabello, con expresión de inmunodeficiencia combinada no severa. Se decidió trasplante de células madre hematopoyéticas. Al momento de este informe, la paciente estaba libre de procesos infecciosos.Conclusión: La hipoplasia cartílago-cabello es un padecimiento con rasgos clínicos y distintos grados de inmunodeficiencia. Como parte del tratamiento es posible realizar trasplante de células madre hematopoyéticas.
Alergia a vegetales pertenecientes a la familia de las solanáceas
Authors: Tomás-Pérez Margarita , Hernández-Martín Irene , Fernández de Alba-Porcel Isabel , Pagola María Jesús , Carretero Pedro , Domínguez-Ortega Javier , Lluch-Bernal María Magdalena , Caballero María Luisa , Quirce Santiago
Published: October 2019

Antecedentes: Aunque se ha descrito reactividad cruzada con alimentos vegetales y látex, la alergia a la papa y al tomate es infrecuente. Objetivo: Estudiar los diferentes patrones de sensibilización en pacientes alérgicos a la patata o tomate.Métodos: Se realizaron pruebas de punción cutánea con extractos y alimentos frescos, determinación de IgE específica y detección de alérgenos mediante SDS-PAGE e IgE-Immunoblotting con extractos de patata y tomate crudos y calientes.Resultados: En 10 pacientes se detectaron alérgenos termoestables a extracto de patata, uno de peso molecular compatible con Sola t 1 (43 kDa, patatina) y otro de 14-22 kDa que podría corresponder a los alérgenos Sola t 4 (16 kDa), Sola t 2 y Sola t 3 (21 kDa); en dos pacientes alérgicos a la patata y dos alérgicos al tomate se detectó un alérgeno termoestable de aproximadamente 42 kDa. En un paciente alérgico al tomate se detectó un alérgeno termoestable compatible con Sola l 2 (50 kDa); había presentado síndrome de alergia oral con algunos tipos de patatas y mostró mayor reactividad IgE a dos alérgenos termoestables de la patata.Conclusiones: Los patrones de sensibilización a los alérgenos fueron similares en los pacientes, independientemente de los síntomas. Se ha detectado un nuevo alérgeno implicado en la alergia a las solanáceas.
Peanut allergy among Mexican adults with allergic respiratory diseases: prevalence and clinical manifestations
Authors: Hernández-Colín Dante Daniel , Fregoso-Zúñiga Eunice , Morales-Romero Jaime , Bedolla-Pulido Tonantzin Isis , Barajas-Serrano Aleyda Carolina , Bedolla-Pulido Angie , Bedolla-Barajas Martín
Published: October 2019

Background: Peanut allergy among adults with respiratory diseases has seldom been studied within Mexico.Objective: To establish the prevalence of peanut allergy among adults that have been diagnosed with either asthma or allergic rhinitis; we will also be describing the symptoms that are associated with peanut allergy.Methods: We carried out a cross-sectional study through which we analyzed the corresponding data of 257 patients with allergic respiratory diseases, asthma or allergic rhinitis, all participants were 16 years of age or older, and were recruited in a consecutive manner. Peanut allergy was established by testing positive to a peanut skin-prick test; we also conducted a standard interview with each patient.Results: From our sample of 257 patients, 18 tested positive to peanut sensitization, (7.0%; 95% CI = 3.9% to 10.1%); among these 18 participants, 7 were considered to be allergic to peanuts (2.7%; 95% IC: 0.7% to 4.7%). Predominant symptoms were oral, primarily affecting the pharynx and the palate, followed by swelling of the lips. When it came to respiratory discomfort, sneezing and rhinorrhea stood out, and lastly there were cutaneous symptoms. We did not detect any systemic reactions to the peanut.Conclusion: In our study, peanut allergy among adults with allergic respiratory diseases is not an uncommon occurrence.
Flujometría versus espirometría para el diagnóstico de asma en adultos
Authors: Herrera-Sánchez Andrea , Álvarez-Chavez Fabián Eduardo , Castillo-Hernández María C. , Orihuela Oscar , Guevara-Balcázar Gustavo , Martínez-Godínez María de los Ángeles , González-Virla Baldomero
Published: October 2019

Antecedentes: El diagnóstico de asma se confirma con espirometría: VEF1 (volumen espiratorio forzado del primer segundo)/CVF (capacidad vital forzada) < 80 %, con reversibilidad (VEF1 >12 % o 200 mL) tras utilizar salbutamol. El flujómetro es barato y fácil de utilizar, mide el flujo espiratorio forzado, cuya reversibilidad > 20 % sugiere asma.Objetivo: Conocer sensibilidad, especificidad y valores predictivos positivos y negativo del flujómetro.Métodos: Estudio transversal, observacional, comparativo. Se incluyó a individuos > 18 años sin contraindicaciones para espirometría, quienes fueron sometidos a espirometría y flujometría y se les aplicó el Asthma Control Test. Se calculó sensibilidad, especificidad y valores predictivos positivo y negativo de la flujometría. Se realizó curva ROC para conocer el punto de corte de mayor sensibilidad y especificidad.Resultados: De 150 pacientes, 66 % fue del sexo masculino; la mediana de edad fue de 38 años. Conforme los criterios de Global Initiative for Asthma 2018, 58.7 % estaba controlado. La sensibilidad de la flujometría fue de 47 %, la especificidad de 87 %, valor predictivo positivo de 54.8 % y negativo de 84 %. La flujometría mostró mayor especificidad con VEF1 < 59 %. El punto de corte de mayor sensibilidad y especificidad fue una reversibilidad de 8 %, con área bajo la curva de 0.70.Conclusiones: El flujómetro tiene mayor sensibilidad en obstrucciones de vía aérea; es de utilidad cuando no se cuenta con un espirómetro.
Alergia a metilprednisolona
Authors: Pérez-Aragón Ana Josefa , Díaz-Molina Manuel , Romero-Paniagua María Teresa , Martínez-Cañavate Ana
Published: October 2019

Los corticoides son fármacos ampliamente utilizados en la práctica médica debido a su potente efecto antiinflamatorio e inmunomodulador. Si bien la mayoría de las reacciones secundarias son muy conocidas, las alérgicas son infrecuentes; la hidrocortisona y la metilprednisolona constituyen los fármacos más comúnmente implicados. Se ha estimado 0.3 % de incidencia de reacciones alérgicas, algunas graves, por lo que la posibilidad de su ocurrencia debe ser considerada cuando se emplean estos medicamentos.
Importancia de los centros de excelencia de la Organización Mundial de Alergia
Authors: Sánchez-Borges Mario , González-Diaz Sandra Nora , Rosenwasser Lanny , Ansotegui Ignacio
Published: October 2019

La Organización Mundial de Alergia (World Allergy Organization) es una federación de sociedades nacionales y regionales de alergia e inmunología clínica cuya misión es promover el desarrollo de estas especialidades a través de programas educativos en congresos, simposios y conferencias en diferentes partes del mundo. Esta alianza mundial de sociedades científicas y profesionales promueve la excelencia en la atención médica de la población mediante la educación, el entrenamiento y la investigación. Actualmente 103 Sociedades Nacionales y Regionales de Alergia e Inmunología Clínica pertenecen a la Organización Mundial de Alergia (https://worldallergy.org).
Correlación: no toda correlación implica causalidad
Authors: Roy-García Ivonne , Rivas-Ruiz Rodolfo , Pérez-Rodríguez Marcela , Palacios-Cruz Lino
Published: October 2019

El concepto de correlación implica contar con un par de observaciones (X y Y), es decir, el valor que toma Y para determinado valor de X; la correlación permite examinar la tendencia de dos variables a ir juntas, por ejemplo, sabemos que al incrementar la edad también aumentan las cifras de presión arterial, por lo tanto, si queremos responder una pregunta de investigación como ¿cuál es la relación entre edad y presión arterial?, la prueba estadística pertinente es una prueba de correlación. Esta prueba permite cuantificar la magnitud de la correlación entre dos variables y ayuda a predecir valores. Si estas variables tuvieran una correlación perfecta se podría inferir el valor de la variable Y conociendo el valor de X. Debido a estas ventajas, la correlación es una de las pruebas más usadas en el ámbito clínico, ya que además de medir la dirección y magnitud de la asociación de dos variables, es uno de los fundamentos de los modelos de predicción, como los modelos de regresión lineal, logística y riesgos proporcionales de Cox.
MENDIDIK ANAK USIA DINI DENGAN BERLANDASKAN PEMIKIRAN TOKOH ISLAM AL-GHAZALI
Authors: Rahmawati Miya
Published: October 2019

Al-Ghazali merupakan salah satu tokoh Muslim yang pemikirannya sangat luas dan mendalam dalam berbagai hal diantaranya dalam masalah pendidikan. Konsep Pendidikan anak yang diusung oleh Al-Ghazali berpijak pada Al-Qur'an dan As-Sunnah sebagai dasar pendidikan anak. Anak yang lahir menurut al-ghazali suci dan bersih orang tua lah yang akan bertanggung jawab mendidiknya. Terdapat dua pendidikan anak tahapan janin dan tahapan kanak-kanak (thifl). Pokok pemikiran al-ghazali dalam mendidik anak : Pentingnya peran orang tua dan pendidikan akhlak bagi anak usia dini, Seimbangkan antara perintah dengan keteladanan. Gunakan metode pengajaran yang sesuai dengan minat dan bakatnya (kecerdasan jamak) Berikan waktu anak untuk bermain Berikan kegiatan positif di waktu luangnya Reward and Punishment. Pendidikan yang dirumuskan Al-Ghazali mencakup banyak aspek yaitu pendidikan keimanan, pendidikan akhlak, pendidikan 'aqliyah, pendidikan sosial dan pendidikan jasmani. Mengenai metode Al-Ghazali menganjurkan penggunaan metode yang bervariasi yang harus disesuaikan dengan tahap perkembangan akal fikiran anak. Seperti hafalan, pemahaman, pembiasaan, latihan dan lain sebagainya. Kata Kunci : Mendidik Anak Usia Dini, Pemikiran, Al-Ghazali
ANALYSIS OF SPEAKING ASSESSMENT IN ESP SPEAKING CLASS
Authors: Ardiyansah Tri Yuli
Published: October 2019

English for Specific Purposes has grown to become one of the most prominent areas of EFL teaching. ESP provides learning of English skills such as: Speaking, Listening, Reading, and Writing. There are also assessment used in ESP for those four skills. In speaking skill, the instruction of the assessment should be given by the instructors based on the objectives of speaking skill itself. In developing speaking test, the instructors should consider on some aspects such as general objective of the test, specific objective of the test, the type of the test, time allotment and how to score the test. This research used qualitative research because the focuses of this research were to explain the assessment process implied by the instructors and to find the kind of assessment type, material, source and scoring used by the instructors in ESP Speaking Class at University of Muhammadiyah Malang. In this research, the writer used Observation, Interview, and Documents as the research instruments. The result of this research showed that the instructors used most of assessment types based on basic types of speaking assessment (Intensive, Responsive, Interactive, and Extensive) excluding (Imitative). The material and source sometimes can vary depending on the each objective of the syllabus. And in the scoring method, the instructors used analytic and holistic scoring.
ANALISIS KUALITAS PELAYANAN INTERNET INDIHOME PADA PT. X DENGAN PENDEKATAN PART LEAST SQUARE
Authors: Winarso Kukuh , Jufriyanto Moh.
Published: October 2019

PT. X Provides paid internet services known as Indihome. The problem that occurs in Indihome Internet service is that there are 42.36% complaints from consumers to the service process provided by PT. X and there is a 7.46% complaint about the amount of the bill. The purpose of this study is to model and know what variables affect the quality of the Indihome Internet service. The method used is Partial Least Square (PLS). Partial Least Square (PLS) is one of the multivariate statistical analysis techniques that can handle multiple response variables and an explanatory variable. The variables used are tangible, empathy, assurance, reliability and responsiveness. The results of the research are the increase of R square value after the implementation of the A5 indicator that does not meet the model PLS. All five variables affect the quality of indihome Internet service is 76,1%. Based on the hypothesis test results on the outer model It is said that the variable indicator is valid with p-value = 0 < 0,05. In testing the inner model obtained that the variable tangible and responsiveness has no significant effect on the quality of Internet service Indihome, while the variable empathy, assurance, reliability significantly affect the quality of service Indihome Internet.
Association of Some High-Risk Mucosal Types of Human Papillomavirus with Cutaneous Squamous Cell Carcinoma in an Iranian Population
Authors: Ehteram Hassan , Mousavian Mohaddeseh Sadat , Mazoochi Tahereh , Khamehchian Tahereh , Karimian Mohammad
Published: October 2019

Background & Objective: Squamous cell carcinoma (SCC) is the second most common non-melanoma skin cancer that may be caused by Human papillomavirus (HPV), especially in immunosuppressed patients. However, the role of the mucosal types of HPV in SCC patients with normal immunity has not been extensively confirmed. The aim of this study was to investigate the association of some high-risk mucosal types of HPV with cutaneous SCC in an Iranian population.
Methods: Sixty-five formalin-fixed, paraffin-embedded tissue specimens with a diagnosis of cutaneous SCC as the case group and sixty-five healthy skin specimens as the control group were included in our case-control study. Genomic DNA was extracted from tissue samples and then PCR was used for the detection of HPV genotypes by a commercial kit.
Results: Our data revealed that 6 out of 65 SCC samples (9.2%) were infected by high-risk mucosal types of HPV whereas none of the 65 control samples were infected by the mentioned HPVs. Statistical analysis showed a significant association between these types of HPV infection and SCC risk in our studied population (P=0.028).
Conclusion: These findings suggested that some high-risk mucosal types of HPV are significant risk factors for cutaneous SCC.
Multiple High Grade Rhabdoid Papillary Meningiomas Mimicking Choroid Plexus Carcinoma: A Case Report
Authors: Eftekhar-Javadi Arezoo , Motevalli Dorna , Pourrashidi Boshrabadi Ahmad , Moradi Tabriz Hedieh , Asefi Hoda
Published: October 2019

Rhabdoid papillary meningioma is an uncommon aggressive variant of meningioma which has the potential to metastasize and spread throughout the brain and even out of the cranium. Herein, we present recurrence of the brain tumor in a 26-year-old woman. The patient had history of the surgery for two lesions in the right temporal lobe and the left cerebellopontine angle. Imaging showed three lesions in the right temporal lobe, the right occipital horn wall, and the left cerebellopontine angle. These radiologic findings were mostly suggestive of atypical meningioma. In the surgical view, the mass was solid-cystic reddish Cauliflower-shaped in the right temporal lobe attaching to the temporal horn. The microscopic examination showed a cellular neoplasm with the sheet-like and papillary growth pattern. Individual cells had vesicular nuclei some with prominent nucleoli and eosinophilic cytoplasm. The areas of the tumor cells showed round eccentric nuclei and prominent nucleoli with eosinophilic cytoplasm. Immunohistochemistry studies showed diffuse positivity of tumor cells with Vimentin, EMA, and S100. The overall clinical, radiological and histopathological examinations were compatible with high grade rhabdoid-papillary meningiomas. In the present case study, we discuss imaging and histomorphological features of this rare entity of meningiomas.
Promoter Methylation of Four Tumor Suppressor Genes in Human Papillary Thyroid Carcinoma
Authors: Khatami Fatemeh , Larijani Bagher , Heshmat Ramin , Nasiri Shirzad , Saffar Hiva , Tavangar Seyed Mohammad
Published: October 2019

Background & Objective: Papillary thyroid cancer (PTC) is considered to be the most common type of thyroid malignancies. Epigenetic alteration, in which the chromatin conformation and gene expression change without changing the sequence of DNA, can occur in some tumor suppressor genes and oncogenes. Methylation is the most common type of epigenetic alterations that can be an excellent indicator of PTC invasive behavior.
Methods: In this research, we determined the promoter methylation status of four tumor suppressor genes (SLC5A8, RASSF1, MGMT, and DNMT1) and compared the results of 55 PTC cases with 40 goiter patients. For methylation, we used the methylation-sensitive high resolution melting (MS-HRM) assay technique. The resulting graphs of each run were compared with those of 0%, 50%, and 100% methylated controls.
Results: Our data showed that the promoter methylation of SLC5A8, Ras association domain family member 1(RASSF1), and MGMT were significantly different between PTC tissue and goiter with P-value less than 0.05. The most significant differences were observed in RASSF1; 77.2% of hyper-methylated PTC patients versus 15.6% hyper-methylated goiter samples (P<0.001).
Conclusion: RASSF1 promoter methylation can be a PTC genetic marker. RASSF1 promoter methylation is under the impact of the methyltransferase genes (DNMT1 and MGMT), protein expression, and promoter methylation.
The Relationship Between Fibroblastic Growth Factor Receptor-1 (FGFR1) Gene Amplification in Triple Negative Breast Carcinomas and Clinicopathological Prognostic Factors
Authors: Jafarian Amir Hossein , Kooshki forooshani Melika , Farzad Farzane , Mohamadian Roshan Nema
Published: October 2019

Background & Objective: In Triple-Negative Breast Cancers (TNBCs), estrogen receptor (ER), progesterone receptor (PR) and HER2/neu genes are not expressed. Fibroblastic Growth Factor Receptor-1 (FGFR1) gene product is a protein that acts as a receptor of thyrosin kinase. It plays a role in the proliferation, differentiation, and migration of malignant cells. The objective was to evaluate the possible relation between FGFR1 over-expression and amplification in TNBCs and other clinicopathological variables.
Methods: In this cross sectional study, purposive sampling was used to collect eighty-four TNBC specimens from mastectomy specimens collected between 2013 and 2017. Tissue microarrays were evaluated for FGFR1 over-expression and amplification respectively by immunohistochemistry (IHC) staining and real time Polymerase Chain Reaction (PCR). The needed clinical and paraclinical information were obtained from patients’ files. To analyze the correlation among prognostic factors, we used a wide range of different statistic methods, namely Chi-square test, independent t-test, Fisher's exact test, and ANOVA.
Results: FGFR1 over-expression was found in 15 of the 84 samples (17.9%). FGFR1 gene amplification was observed in 33.3% (28 of 84) of the samples. We found no association between FGFR1 and clinicopathological parameters, including tumor grade, stage, and patient survival (P>0.005).
Conclusion: FGFR1 over-expression and amplification may not be related to clinicopathological parameters, namely age, stage, and grade of the cancer not to mention TNBC survival. Using FGFR1 as a prognostic factor in TNBCs requires further study.
Espionage Competitors’ Activity Through Social Media
Authors: Prawiro Hans
Published: October 2019

Tracking competitors through social media become a trend of marketing strategies
The moving learner: Object manipulation in VR improves vocabulary learning
Authors: Fuhrman Orly , Eckerling Anabel , Friedmann Naama , Tarrasch Ricardo , Raz Gal
Published: October 2019

A challenging part of foreign language acquisition is learning new vocabulary. Research has demonstrated the benefits of motor action to vocabulary learning, though these findings are rarely translated into teaching and learning practices. In this work we present a novel paradigm for vocabulary learning in a virtual reality environment, capitalizing on the prominent advantages of this technology as an ‘embodied’ learning tool. Hebrew-speaking adults explored a virtual room and learned the Finnish names of 40 daily objects. Every participant learned the new object names under 3 conditions: (1) Watch-only: watching the object without performing any movement (2) performing an irrelevant movement, or (3) performing a manipulation movement that implied its habitual use. Participants completed a word-picture matching test after each training block, as well as additional word-picture matching and recall tests a week after the initial training session. The overall results demonstrate improved comprehension rates for items that were learned in the manipulation movement condition compared to the irrelevant movement condition, both in the initial learning session and one week following it. These initial findings suggest that VR technology may indeed hold the potential to offer a more authentic, multisensory and motor context to efficient foreign language learning.
EFEITO DA NATAÇÃO SOBRE A POSTURA CORPORAL DE ADOLESCENTES
Authors: Plucinski Cardoso Ribas Nathalie Yelena , Staudt Ribas Silvan , Lara Simone , De Souza Balk Rodrigo , Goulart Lanes Karoline , Graup Susane
Published: October 2019

O objetivo deste estudo foi avaliar o efeito da natação sobre a postura corporal de adolescentes. A amostra foi composta por nove adolescentes, participantes de um projeto de extensão universitária, os quais participaram de 20 sessões de natação, com duração de uma hora, duas vezes por semana, ao longo de 10 semanas. A avaliação da postura corporal foi analisada pré e pós-intervenção, por meio do Software de Avaliação Postural (SAPo). Para análise de dados foi utilizada estatística descritiva e para comparar os resultados das variáveis entre o pré e o pós-teste foi utilizado o teste de Wilcoxon. No pré-teste as alterações posturais mais frequentes foram: protrusão de ombro (77,7%), desalinhamento horizontal das espinhas ilíacas anterossuperiores (55,5%) e a diferença de comprimento nos membros inferiores (55,5%); já no pós-teste, persistiram apenas as duas últimas citadas como as mais frequentes (44,4%). Também ocorreu uma redução dos desvios posturais por indivíduo no pós-teste. Dessa forma, a prática de natação contribuiu para melhorar a postura corporal dos adolescentes, através da diminuição dos desvios posturais.
ANÁLISE SISTEMÁTICA DOS ARTIGOS DE GEOMETRIA PUBLICADOS NO BOLETIM DE EDUCAÇÃO MATEMÁTICA NO PERÍODO 2008 A 2017
Authors: Heck Miriam Ferrazza , Kaiber Carmen Teresa
Published: October 2019

Apresenta-se neste trabalho, uma análise sistemática dos artigos sobre Geometria que foram publicados no periódico, Boletim de Educação Matemática- BOLEMA, o qual possui avaliação Qualis A1, na área de Ensino de Matemática. O objetivo principal desta investigação foi conhecer todas as pesquisas relacionadas com o ensino e a aprendizagem de Geometria desenvolvida na Educação Básica e no Ensino Superior. A metodologia utilizada foi de uma pesquisa qualitativa, sendo que, os dados empíricos são provenientes do site do periódico BOLEMA. O processo de análise teve inicio com o levantamento de todos os trabalhos que abordavam algum assunto relacionado à Geometria, sendo que, foram encontrados 64 trabalhos (artigos, resenhas, resumos teses e dissertações). Posteriormente, foi realizada a leitura sistemática de todos os trabalhos e optou-se por selecionar apenas os artigos para serem analisados, visto que, apresentam-se de forma mais completa e consistente os resultados das suas pesquisas. Os resultados demostram uma natureza diversificada de pesquisas sobre Geometria, ao mesmo tempo em que, ampliam as possibilidades de investigações neste âmbito, com a inserção de softwares educativos, ferramentas pedagógicas auxiliares, assim como, possibilidades diversificadas de metodologias para o ensino e aprendizagem de Geometria.
A Close Look at Echium amoenum Processing, Neuroactive Components, and Effects on Neuropsychiatric Disorders
Authors: Nouri Mohammad , Farajdokht Fereshteh , Torbati Mohammadali , Ranjbar Kuchaksaray Fatemeh , Hamedyazdan Sanaz , Araj-khodaei Mostafa , Sadigh-Eteghad Saeed
Published: October 2019

Pharmacological researches in the area of herbal medicine have considerably increased over the last two centuries. Echium amoenum (known as Gol-e-Gavzaban in Persian) is a medicinal plant that has been widely used in Iranian folk medicine. In this review, databases including PubMed, Scopus, and Google Scholar were searched up. Data collecting was completed by January 2019 and available scientific reports regarding the processing methods, main chemical constituents, and effects of E. amoenum on different neuropsychiatric disorders are summarized. Thirteen five studies met the inclusion criteria. According to results, the important phytochemicals of the plant was phenolic compounds, fatty acids, rosmarinic acid, anthocyanidins, and flavonoids. Also, experimental and clinical studies demonstrated the effectiveness of E. amoenum in the treatment of several neuropsychiatric disorders such as anxiety, depression, ischemic stroke, seizure, Alzheimer’s disease, and pain. Many of these effects are, at least in part, due to its rosmarinic acid or polyphenolic compounds such as flavonoids and natural pigments such as anthocyanins. Also, fatty acids such as gamma-linolenic acid play critical role in neuroactive properties of this herb. Among these effects, only the antidepressant and anxiolytic properties of the plant extract have been examined both experimentally and clinically. There was some controversy over its toxicity effects. It seems that E. amoenum protects neurons via attenuation of oxidative stress and inflammation as well as blocking of apoptosis in the nervous system. However, more studies are necessary for assessing exact mechanisms of action in neuropsychiatric disorders, finding of bioactive ingredients, and processing methods of this plant. [GMJ.2019;8:e1559]
PARADIGM OF LEADERSHIP FOR ORGANIZATIONAL INNOVATION BASED ON THEORY U
Authors: Bernardo Cleice de Pontes , Silva Rwrsilany , Filho Prof. Dr. Flávio de São Pedro , Barbosa Raul Afonso Pommer
Published: October 2019

Leadership paradigms are the attributes that a leader must possess for efficient and innovative leadership. Theory U is used as an argument in this discussion. The objective of this essay is to consider the paradigms of transformational leadership for the consolidation of a culture of innovation in the organization. This task of qualitative and exploratory research. The results of the present study suggest that consolidating a culture of innovation in the organization implies an impressive change in the modus operandi, with an open-minded team, also essential as a agent of change, led in an appropriate and creative environment. To make this possible, leadership must use the paradigms of transformational leadership as well as the culture-creativity-team trilogy. In addition, the change agent must disseminate the values of creativity and innovation in the everyday activities of the team, besides instigating internal actions that invigorate this culture.
COMMUNITY ODONTOLOGY AND FAMILY HEALTH STRATEGY IN DISCUSSION
Authors: FERMINO J. , CUNHA L. R. da. , LIMA R. C. G. S
Published: October 2019

This article discusses the way how members of a family, living in a socially vulnerable community, perceive their own health and the community dental practices performed by the Family Health Strategy. The context of the study is the axis on the condition of life of the care model, as recommended by the National Policy of Buccal Health that foresees the approach of the population from their familiar universe and from the social relations experienced in the territory. It is a social study of qualitative, exploratory and descriptive approach carried out in a municipality of Santa Catarina by means of collective interview and adjusted thematic analysis. By means of the category “Bonds in a community cultural reality”, the data analysis revealed that both health and community dental practices are perceived through relations that express the subalternity, the intersubjectivity, the willingness to work, the bond with the evangelical church, life through arts, and sexual violence. The conclusion drawn is that materialization of the model of care, through the axis life conditions of the communities, requires the problematization of professional certainties generated by the hegemonic production of a technical scientism detached from the real life of vulnerable families.
Surgical strategy for focal cortical dysplasia based on the analysis of the spike onset and peak zones on magnetoencephalography
Authors: Shirozu Hiroshi , Hashizume Akira , Masuda Hiroshi , Kakita Akiyoshi , Otsubo Hiroshi , Kameyama Shigeki
Published: October 2019

OBJECTIVE

The aim of this study was to elucidate the surgical strategy for focal cortical dysplasia (FCD) based on the interictal analysis on magnetoencephalography (MEG). For this purpose, the correlation between the spike onset zone (Sp-OZ) and the spike peak zone (Sp-PZ) on MEG was evaluated to clarify the differences in the Sp-OZ and its correlation with Sp-PZ in FCD subtypes to develop an appropriate surgical strategy.

METHODS

Forty-one FCD patients (n = 17 type I, n = 13 type IIa, and n = 11 type IIb) were included. The Sp-OZ was identified by the summation of gradient magnetic-field topography (GMFT) magnitudes at interictal MEG spike onset, and Sp-PZ was defined as the distribution of the equivalent current dipole (ECD) at spike peak. Correlations between Sp-OZ and Sp-PZ distributions were evaluated and compared with clinical factors and seizure outcomes retrospectively.

RESULTS

Good seizure outcomes (Engel class I) were obtained significantly more often in patients with FCD type IIb (10/11, 90.9%) than those with type IIa (4/13, 30.8%; p = 0.003) and type I (6/17, 35.3%; p = 0.004). The Sp-OZ was significantly smaller (1 or 2 gyri) in type IIb (10, 90.9%) than in type IIa (4, 30.8%; p = 0.003) or type I (9, 53.0%; p = 0.036). Concordant correlations between the Sp-OZ and Sp-PZ were significantly more frequent in type IIb (7, 63.6%) than in type IIa (1, 7.7%; p = 0.015) or type I (1, 5.8%; p = 0.004). Complete resection of the Sp-OZ achieved significantly better seizure outcomes (Engel class I: 9/10, 90%) than incomplete resection (11/31, 35.5%) (p = 0.003). In contrast, complete resection of the Sp-PZ showed no significant difference in good seizure outcomes (9/13, 69.2%) compared with incomplete resection (11/28, 39.3%).

CONCLUSIONS

The Sp-OZ detected by MEG using GMFT and its correlation with Sp-PZ were related to FCD subtypes. A discordant distribution between Sp-OZ and Sp-PZ in type I and IIa FCD indicated an extensive epileptogenic zone and a complex epileptic network. Type IIb showed a restricted epileptogenic zone with the smaller Sp-OZ and concordance between Sp-OZ and Sp-PZ. Complete resection of the Sp-OZ provided significantly better seizure outcomes than incomplete resection. Complete resection of the Sp-PZ was not related to seizure outcomes. There was a definite difference in the epileptogenic zone among FCD subtypes; hence, an individual surgical strategy taking into account the correlation between the Sp-OZ and Sp-PZ should be considered.
Cerebrospinal fluid macrophage migration inhibitory factor: a potential predictor of cerebral vasospasm and clinical outcome after aneurysmal subarachnoid hemorrhage
Authors: Kwan Kevin , Arapi Orseola , Wagner Katherine E. , Schneider Julia , Sy Heustein L. , Ward Mary Frances , Sison Cristina P. , Li Chunyan , Eisenberg Mark B. , Chalif David , Narayan Raj K. , Miller Edmund J. , Ledoux David
Published: October 2019

OBJECTIVE

In patients with aneurysmal subarachnoid hemorrhage (aSAH), poor outcomes have been shown to be correlated with subsequent cerebral vasospasm (CV) and delayed cerebral ischemia (DCI). The identification of novel biomarkers may aid in the prediction of which patients are vulnerable to developing vasospasm, cerebral ischemia, and neurological deterioration.

METHODS

In this prospective clinical study at North Shore University Hospital, patients with aSAH or normal pressure hydrocephalus (NPH) with external ventricular drains were enrolled. The concentration of macrophage migration inhibitory factor (MIF) in CSF was assessed for correlation with CV or DCI, the primary outcome measures.

RESULTS

Twenty-five patients were enrolled in the aSAH group and 9 were enrolled in the NPH group. There was a significant increase in aggregate CSF MIF concentration in patients with aSAH versus those with NPH (24.4 ± 19.2 vs 2.3 ± 1.1 ng/ml, p < 0.0002). Incidence of the day of peak MIF concentration significantly correlated with the onset of clinical vasospasm (rho = 0.778, p < 0.0010). MIF concentrations were significantly elevated in patients with versus those without evidence of DCI (18.7 ± 4.93 vs 8.86 ± 1.28 ng/ml, respectively, p < 0.0025). There was a significant difference in MIF concentrations between patients with infection versus those without infection (16.43 ± 4.21 vs 8.5 ± 1.22 ng/ml, respectively, p < 0.0119).

CONCLUSIONS

Preliminary evidence from this study suggests that CSF concentrations of MIF are correlated with CV and DCI. These results, however, could be confounded in the presence of clinical infection. A study with a larger patient sample size is necessary to corroborate these findings.
Preoperative tumor-associated epilepsy in patients with supratentorial meningioma: factors influencing seizure outcome after meningioma surgery
Authors: Schneider Matthias , Güresir Ági , Borger Valeri , Hamed Motaz , Rácz Attila , Vatter Hartmut , Güresir Erdem , Schuss Patrick
Published: October 2019

OBJECTIVE

Both pre- and postoperative seizures comprise common side effects that negatively impact patient quality of life in those suffering from intracranial meningioma. Therefore, seizure freedom represents an important outcome measure in meningioma surgery. In the current study the authors analyzed their institutional database to identify risk factors for postoperative seizure occurrence after surgical meningioma therapy in patients with preoperative symptomatic epilepsy.

METHODS

Between February 2009 and April 2017, 187 patients with preoperative seizures underwent resection of supratentorial meningioma at the authors’ institution. Seizure outcome was assessed retrospectively 12 months after tumor resection according to the International League Against Epilepsy (ILAE) classification and stratified into favorable (ILAE class I) versus unfavorable (ILAE classes II–VI). A univariate and multivariate analysis was performed to identify factors influencing seizure outcome.

RESULTS

Overall 169 (90%) of 187 patients with preoperative seizures achieved favorable outcome in terms of seizure freedom after meningioma resection. Multivariate analysis revealed peritumoral edema > 1 cm in maximal diameter and WHO grade II and III tumors, as well as a low extent of resection (Simpson grades III–V) as independent predictors for postoperative unfavorable seizure outcome.

CONCLUSIONS

Surgery is highly effective in the treatment of seizures as common side effects of supratentorial meningioma. Furthermore, the present study identified several significant and independent risk factors for postoperative seizure occurrence, enabling one to select for high-risk patients that require special attention in clinical and surgical management.
Expansive carotid artery remodeling: possible marker of vulnerable plaque
Authors: Yoshida Kazumichi , Yang Tao , Yamamoto Yu , Kurosaki Yoshitaka , Funaki Takeshi , Kikuchi Takayuki , Ishii Akira , Kataoka Hiroharu , Miyamoto Susumu
Published: October 2019

OBJECTIVE

Accumulated findings in the pathophysiology of atherosclerosis have demonstrated that not only luminal narrowing but also plaque characteristics influence the risk of future ischemic events. The morphology of the carotid artery (CA) changes in response to atherosclerotic development by expansive remodeling (ER), the clinical significance of which remains unclear. This study aimed to define associations between ER and local risk factors, including CA geometry and traditional systemic risk factors for ischemic events, to determine whether ER could serve as a clinical marker of carotid vulnerable plaque.

METHODS

The authors retrospectively analyzed 66 patients with CA stenosis who were scheduled to undergo carotid endarterectomy or CA stenting. They calculated ER ratios in the internal CA (ICA) from long-axis MR images and as the maximal distance between the lumen and the outer borders of the plaque perpendicular to the axis of the ICA/the maximal luminal diameter of the distal ICA at a region unaffected by atherosclerosis. Relative overall signal intensity (roSI) was calculated to assess intraplaque hemorrhage and defined as the signal intensity of plaque on an axial T1-weighted image with maximal stenosis relative to that of the adjacent sternocleidomastoid muscle. The authors evaluated CA geometry by calculating the angles between the common CA (CCA) and ICA, and between the CCA and external CA (ECA) using digital subtraction angiography. The ER ratios, age, sex, percentage of stenosis, roSI, hypertension, hyperlipidemia, low-density lipoprotein, statin medication, diabetes, smoking habit, and ischemic heart disease were compared between 33 symptomatic and 33 asymptomatic patients. The authors also compared symptomatic status, age, sex, percentage of stenosis, ICA angle, ECA angle, roSI, and other traditional atherosclerotic risk factors between groups with extensive and slight ER.

RESULTS

The ER ratio was significantly greater in symptomatic than in asymptomatic patients (1.91 ± 0.46 vs 1.68 ± 0.40, p < 0.05). The ICA angle was significantly larger in the group with extensive ER than in those with slight ER (33.9° ± 20.2° vs 21.7° ± 13.8°, p < 0.01). The roSI, ECA angle, percentage stenosis, or any other traditional vascular risk factors were not associated with ER.

CONCLUSIONS

Carotid ER might be an independent indicator of carotid vulnerable plaque, which should be validated in a longitudinal study of patients with carotid atherosclerosis, including those with nonstenotic to moderate stenosis.
Predominance of M1 subtype among tumor-associated macrophages in phenotypically aggressive sporadic vestibular schwannoma
Authors: Perry Avital , Graffeo Christopher S. , Carlstrom Lucas P. , Raghunathan Aditya , Driscoll Colin L. W. , Neff Brian A. , Carlson Matthew L. , Parney Ian F. , Link Michael J. , Van Gompel Jamie J.
Published: October 2019

OBJECTIVE

Tumor-associated macrophages (TAMs) have been implicated as pathologic actors in phenotypically aggressive vestibular schwannoma (VS), potentially mediated via programmed death-ligand 1 (PD-L1). The authors hypothesized that PD-L1 is a key regulator of the VS immune microenvironment.

METHODS

Forty-six consecutive, radiation-naïve, sporadic VSs that were subtotally resected at primary surgery were assessed via immunohistochemical analysis, including analysis of CD163 and PD-L1 expression. Pathologic data were correlated with clinical endpoints, including tumor control, facial nerve function, and complications.

RESULTS

Baseline parameters were equivalent between stable and progressive post–subtotal resection (STR) VS. CD163 percent positivity and M2 index were significantly increased among tumors that remained stable (34% vs 21%, p = 0.02; 1.13 vs 0.99, p = 0.0008), as well as patients with favorable House-Brackmann grade I or II facial nerve function (31% vs 13%, p = 0.04; 1.11 vs 0.97, p = 0.05). PD-L1 percent positivity was significantly associated with tumor progression (1% vs 11%, p = 0.01) and unfavorable House-Brackmann grade III–VI facial nerve function (1% vs 38%, p = 0.02). On multivariate analysis, PD-L1 was independently significant in all models (likelihood ratio 4.4, p = 0.04), while CD163 was dependent in all iterations.

CONCLUSIONS

In contrast to prior reports, in this study, the authors observed significantly increased levels of M1, CD163+ TAMs in association with VS that progressed after STR. Progressive tumors are characterized by increased PD-L1, potentially highlighting a mechanism of immune evasion that results in TAM deactivation, tumor growth, and further infiltration of anti-tumor immune cells. Targeting PD-1/PD-L1 may offer therapeutic promise, particularly in the setting of disease control after STR.
PERAN KEPALA SEKOLAH DAN IKLIM ORGANISASI DALAM PENINGKATAN KINERJA GURU SEKOLAH DASAR
Authors: Patno
Published: October 2019

Tujuan Penelitian ini untuk mengetahui: (1) pengaruh peran kepala sekolah terhadap peningkatan kinerja guru Sekolah Dasar (SD) di Kabupaten Indramayu; (2) pengaruh iklim Organisasi terhadap kinerja guru Sekolah Dasar di Kabupaten Indramayu; (3) pengaruh peran kepala sekolah dan iklim organisasi terhadap kinerja guru Sekolah Dasar (SD) di Kabupaten Indramayu. Guna mengetahui tujuan penelitian tersebut maka menggunakan rancangan penelitian deskriptif korelasional. Penelitian ini dilaksanakan di sembilan sekolah dasar yang ada di gugus II di UPTD Pendidikan Kecamatan Anjatan dengan jumlah pupulasi sebanyak 79 orang. Sampel diambil secara random proporsional. Pengumpulan data dalam penelitian ini menggunakan kuisioner atau angket sebagai instrumen. Hasil penelitian menunjukkan bahwa: (1) terdapat kontribusi pengaruh peran kepala sekolah terhadap kinerja guru SD Negeri pada Gugus II di UPTD Pendidikan Kecamatan Anjatan Kabupaten Indramayu tergolong signifikan yakni sebesar 18,3 %; (2) tingkat iklim organisasi termasuk kategori sedang 28,8%, (3) pengaruh peran kepala sekolah dan iklim organisasi secara bersama-sama terhadap kinerja guru sebesar 34,4%; (4) terdapat hubungan yang signifikan antara peran kepala sekolah dan iklim dengan kinerja guru; (5) terdapat hubungan yang signifikan antara iklim organisasi dengan kinerja guru; (6) terdapat hubungan signifikan antara peran kepala sekolah dan iklim organisasi.
INTEGRITAS KEPEMIMPINAN KEPALA SEKOLAH DAN BUDAYA ORGANISASI SERTA PENGARUHNYA TERHADAP EFEKTIVITAS KERJA GURU
Authors: Areagama
Published: October 2019

Fokus penelitian ini bertujuan untuk mengetahui integrasi kepemimpinan kepala sekolah dan budaya organisasi sekolah serta pengaruhnya terhadap efektivitas kerja guru. Metode penelitian yang digunakan adalah metode survey dengan cara menyebarkan angket kepada 104 responden. Pengambilan sampel menggunanakan teknik Cluster Random Sampling. Data yang diperoleh dari hasil penelitian diolah menggunakan analisis statistik, deskriptif dilengkapi dengan analisis regresi sederhana dan regresi ganda. Hasil penelitian menunjukkan bahwa: (1) Terdapat pengaruh positif dan signifikan integritas kepemimpinan kepala sekolah terhadap efektivitas kerja guru. (2) Terdapat pengaruh positif dan signifikan budaya organisasi sekolah terhadap efektivitas kerja guru. (3) Terdapat pengaruh positif dan signifikan integritas kepemimpinan kepala sekolah dan budaya organisasi sekolah secara simultan terhadap efektitivitas kerja guru. Beranjak dari kondisi yang ada, penulis menyarankan: (1) Dalam rangka meningkatkan integritas kepemimpinannya, kepala sekolah perlu meningkatkan keterpaduan dalam memimpin serta lebih transparan dalam mengelola sekolah melalui komunikasi rutin dengan guru sebagai mitra kerjanya. (2) Budaya organisasi sekolah juga merupakan salah satu yang dapat meningkatkan efektivitas kerja guru. Untuk itu, kepala sekolah perlu meningkatkan toleransi terhadap tindakan berisiko dan toleransi terhadap konflik dengan cara membangun pola komunikasi yang lebih mudah dipahami oleh semua elemen di sekolah.
ANALISIS JARINGAN KERJA PADA EVALUASI PENJADWALAN WAKTU DAN BIAYA PENYELESAIAN PROYEK DENGAN MENGGUNAKAN METODE PERT & CPM
Authors: Asri Dhonna Febby Lintang , Setiawan Tabah Heri , Rusdiana Yulianti
Published: October 2019

PERT dan CPM merupakan suatu metode yang bertujuan untuk meminimalisir adanya gangguan dan penundaan dalam tahap produksi sehingga dapat mengevaluasi penjadwalan waktu dan biaya dalam penyelesaian proyek. Tugas Akhir ini membahas tentang metode PERT dan CPM dalam mengevaluasi waktu dan biaya yang telah ditentukan oleh CV. Mitra Data Perkasa dalam pengerjaan proyek pengelolaan arsip inaktif. Penelitian ini mendapatkan waktu tercepat dalam penyelesaian proyek dengan menggunakan jalur kritis (critical path) selama 80 hari kerja. Hasil evaluasi penjadwalan dengan metode PERT dan CPM memperoleh hasil yang baik dalam mempercepat penyelesaian proyek.