bluuebunny/crossref_metadata_2025 huggingface dataset:
Pathologization, Law, and Gender in Cases of Infanticide in Spain and the Netherlands in the Mid-Twentieth Century: A Comparative Perspective
Authors: Ruberg Willemijn , Serrano Martínez Sara
Published: January 2024

This article compares how gender and pathologization were entangled in the laws on infanticide in Spain and the Netherlands in 1930–1960, as well as in court practices. Both countries knew lenient laws for women who killed their newborn babies. These laws themselves did not assume that these women were suffering from a mental disorder, even though they referred to emotional state. In Spain, where the notion of honor was more important in the law, from the 1940s a debate was held about the relationship between mental illness and infanticide laws in the context of the Franco regime's emphasis on pronatalism. While in Spain the institutional monopoly of the generalist forensic physician as preferred expert excluded psychiatrists, in the Netherlands forensic psychiatrists were more influential, and their role increased from the 1950s. The article argues that regardless of many differences in forensic and political culture in both countries infanticidal women were pathologized: in Spain mostly via some interpretations of the infanticide law, and in the Netherlands via forensic psychiatry. However, pathologization, we show, involved many lay actors such as lawyers, legal scholars, and probation services.
Seroprevalence of severe acute respiratory syndrome coronavirus 2 N antibodies between December 2021 and march 2023 in Japan
Authors: Yamayoshi Seiya , Nagai Etsuko , Mitamura Keiko , Hagihara Masao , Kobayashi Ryo , Takahashi Satoshi , Shibata Akimichi , Uwamino Yoshifumi , Hasegawa Naoki , Iqbal Asef , Kamimaki Isamu , Iwatsuki-Horimoto Kiyoko , Nagamura-Inoue Tokiko , Kawaoka Yoshihiro
Published: January 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019 in China and rapidly spread worldwide, leading to a pandemic. The threat of SARS-CoV-2 is subsiding as most people have acquired sufficient antibodies through vaccination and/or infection to prevent severe COVID-19. After the emergence of the omicron variants, the seroprevalence of antibodies against the N protein elicited by SARS-CoV-2 infection ranged from 44.4% to 80.2% in countries other than Japan. Here, we assessed the seroprevalence in Japan before and after the appearance of omicron variants. Serosurveillance of antibodies against N was conducted between December 2021 and March 2023 in Japan. In total, 7604 and 3354 residual serum or plasma samples were collected in the Tokyo metropolitan area and Sapporo, respectively. We found that the seroprevalence in representative regions of Japan increased approximately 3% to 23% after the emergence of the omicron variants. We also found higher seroprevalence among the young compared with the elderly. Our findings indicate that unlike other countries, most of the Japanese population has not been infected, raising the possibility of future SARS-CoV-2 epidemics in Japan.
Paediatric heart transplantation: life-saving but not yet a cure
Authors: Boucek Robert , Chinnock Richard , Scheel Janet , Deshpande Shriprasad R. , Urschel Simon , Kirklin James
Published: January 2024

In the 1980s, heart transplantation was the first successful treatment for infants born with hypoplastic left heart syndrome. Infants who have required heart transplantation benefit from immunologic “advantages,” including long-term survival free from cardiac allograft vasculopathy. Currently ∼ 90% of children undergoing a heart transplant are reaching their first-year anniversary and the clinical practices of paediatric heart transplantation have dramatically improved. These successes are largely attributed to research sponsored by the Pediatric Heart Transplant Study Group, the International Society of Heart and Lung Transplantation and, more recently, the Non-profits Enduring Hearts and Additional Ventures. Despite these successes, the field is challenged to increase progress to achieve long-term survival into adulthood. The wait-list mortality, especially among infants, is unacceptably high often leading to palliative measures that can increase post-transplant mortality. Cardiac allograft vasculopathy remains a major cause for progressive graft loss of function and sudden death. The relative tolerance seen in immature recipients has not been translated to modifying older recipients’ post-transplant outcomes. The modifiable cause(s) for the increased risks of transplantation in children of different ethnicities and races require definition. Addressing these challenges faces the reality that for-profit research favours funding adult recipients, with ∼ 10-fold greater numbers, and their more modest longevity goals. Advocacy for funding “incentives” such as the Orphan Drug rules in the United States and upholding principles of equity and inclusion are critical to addressing the challenges of paediatric heart transplant recipients worldwide.
Empirically derived portion sizes from the DOrtmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study for 4- to 18-year-old children and adolescents to simplify analysis of dietary data using FFQ
Authors: Schnermann Maike Elena , Nöthlings Ute , Alexy Ute
Published: January 2024

Objective:

To apply FFQ, knowledge about portion sizes is relevant. According to increased energy and nutrient requirements, average portion sizes of foods are supposed to increase during growth. We provide empirically derived portion sizes for 4- to 18-year-olds in different age groups to facilitate analyses of FFQ data in children and adolescents.

Design:

Using data from the dynamic DOrtmund Nutritional and Anthropometric Longitudinally Designed cohort study, quantile regression for smoothing percentiles was used to derive portion sizes as a function of age from which age- and food group-specific portion sizes were calculated as median food group intake (g).

Setting:

Dortmund, Germany.

Participants:

Data from 3-day weighed dietary records (WDR) of 1,325 participants (♀: 653) were analysed. Participants provided in total 9,828 WDR (on average 7·5 per participant) between 1985 and 2022. WDR were grouped into five age groups, whereby each age group covered 3 years of age.

Results:

In total, 11 955 food items were reported and categorised into sixteen major food groups with seventy-one sub-groups. Portion sizes tended to increase with age, except for milk- and plant-based alternatives. Comparing 4- to 6-year-olds to 16- to 18-year-olds, portion size increased between 22·2 % (processed meat: 18 g v. 22 g) and 173·3 % (savoury snacks: 15 g v. 41 g).

Conclusion:

We provide empirically derived portion sizes for children and adolescents. These data are useful to establish dietary assessment methods based on estimates of portion sizes, such as FFQ, for children and adolescents.
Applicability of Object Detection to Microfossil Research: Implications From Deep Learning Models to Detect Microfossil Fish Teeth and Denticles Using YOLO‐v7
Authors: Mimura K. , Nakamura K. , Yasukawa K. , Sibert E. C. , Ohta J. , Kitazawa T. , Kato Y.
Published: January 2024

Microfossils of fish teeth and denticles, referred to as ichthyoliths, provide critical information for depositional ages, paleo‐environments, and marine ecosystems, especially in pelagic realms. However, owing to their small size and rarity, it is time‐consuming and difficult to analyze large numbers of ichthyoliths from sediment samples, limiting their use in scientific studies. Here, we propose a method to automatically detect ichthyoliths from microscopic images using a deep learning technique. We applied YOLO‐v7, one of the latest object detection architectures, and trained several models under different conditions. The model trained under appropriate conditions with an original data set achieved an F1 score of 0.87. We then enhanced the data set efficiently using the pre‐trained model. We validated the practical applicability of the model by comparing the number of ichthyoliths detected by the model with those counted manually. This revealed that the best model can predict the number of triangular teeth, denticles and irregularly shaped teeth with minimal human intervention. This object detection method can extend the applicability of deep learning to a wider array of microfossils and has the potential to dramatically increase the spatiotemporal resolution of ichthyolith records for applications across disciplines.
Anthropogenic Dust as a Significant Source of Ice‐Nucleating Particles in the Urban Environment
Authors: Chen Jie , Wu Zhijun , Gong Xianda , Qiu Yanting , Chen Shiyi , Zeng Limin , Hu Min
Published: January 2024

Anthropogenic dust is an important constituent of airborne particles in the urban environment but its ice nucleation activity remains poorly investigated. Here, we studied the sources and ice nucleating properties of size‐resolved particles in the urban atmosphere under mixed‐phase cloud conditions. The heat‐resistant ice nucleating particles (INPs) unexpectedly contributed ∼70% of the supermicron INPs at temperatures below −15°C. A detailed chemical composition analysis of size‐resolved particles revealed that these INPs were associated with anthropogenic dust, such as traffic‐influenced road dust. A parameterization based on supermicron particles was developed to predict the anthropogenic dust INP concentration, given their correlations on concentration and similarity in chemical compositions. Once integrated into global models, this parameterization holds the potential to assess the contribution of anthropogenic dust to INPs on a global scale. Given the considerable presence of anthropogenic dust in the atmosphere and its significant role as INPs, we suggest it may be an important aerosol source influencing cloud microphysics and warrant further investigations.
Evaporation Loss From Small Agricultural Reservoirs in a Warming Climate: An Overlooked Component of Water Accounting
Authors: Aminzadeh Milad , Friedrich Noemi , Narayanaswamy Sankeerth , Madani Kaveh , Shokri Nima
Published: January 2024

Small agricultural reservoirs support water demands during dry spells. However, evaporative losses that are often overlooked in water accounting and management diminish the storage efficiency of these popular but un‐inventoried resources. We developed a predictive framework to identify the spatio‐temporal extent of small reservoirs (900–100,000 m2) and quantify their evaporative losses using a physically‐based model. Focusing on water‐stressed regions of Europe (Italy, Spain, and Portugal), our results indicate that the total number and cumulative area of small reservoirs in drier areas of Europe almost doubled in two decades from about 6,200 reservoirs with the cumulative area of 46 km2 in 2,000 to 11,800 reservoirs with the cumulative area of 93.5 km2 in 2020. We observed climate‐driven trends in the expansion of agricultural reservoirs and their evaporative losses which exceeded 72 million cubic meters during warm months (April to September) accounting for 38% of their total storage capacity.
Greenspace and Land Cover Diversity During Pregnancy in a Rural Region, and Associations With Birth Outcomes
Authors: Chipman Jonathan W. , Shi Xun , Gilbert‐Diamond Diane , Khatchikian Camilo , Baker Emily R. , Nieuwenhuijsen Mark , Karagas Margaret R.
Published: January 2024

Beneficial effects on health outcomes have been observed from exposure to spaces with substantial green vegetation (“greenspace”). This includes studies of greenspace exposure on birth outcomes; however, these have been conducted largely in urban regions. We characterized residential exposure to greenspace and land cover diversity during pregnancy in rural northern New England, USA, investigating whether variation in greenspace or diversity related to newborn outcomes. Five landscape variables (greenspace land cover, land cover diversity, impervious surface area, tree canopy cover, and the Normalized Difference Vegetation Index) were aggregated within six circular zones of radii from 100 to 3,000 m around residential addresses, and distance to conservation land was measured, providing a total of 31 greenspace and diversity metrics. Four birth outcomes along with potentially confounding variables were obtained from 1,440 participants in the New Hampshire Birth Cohort Study. Higher greenspace land cover up to 3,000 m was associated with larger newborn head circumference, while impervious surface area (non‐greenspace) had the opposite association. Further, birth length was positively associated with land cover diversity. These findings support beneficial health impacts of greenspace exposure observed in urban regions for certain health outcomes, such as newborn head circumference and length but not others such as birthweight and gestational age. Further our results indicate that larger radius buffer zones may be needed to characterize the rural landscape. Vegetation indices may not be interchangeable with other greenspace metrics such as land cover and impervious surface area in rural landscapes.
Permeability and Elastic Properties of Rocks From the Northern Hikurangi Margin: Implications for Slow‐Slip Events
Authors: Tisato Nicola , Bland Carolyn D. , Van Avendonk Harm , Bangs Nathan , Garza Hector , Alamoudi Omar , Olsen Kelly , Gase Andrew
Published: January 2024

Fluid flow and pore‐pressure cycling are believed to control slow slip events (SSEs), such as those that frequently occur at the northern Hikurangi margin of New Zealand. To better understand fluid flow in the forearc system we examined the relationship between several physical properties of Cretaceous‐to‐Pliocene sedimentary rocks from the Raukumara peninsula. We found that the permeability of the deep wedge is too low to drain fluids, but fracturing increases permeability by orders of magnitude, making fracturing key for fluid flow. In weeks to months, plastic deformation, swelling, and possibly not‐yet‐identified mechanisms heal the fractures, restoring the initial permeability. We conclude that overpressures at the northern HM might partly dissipate during SSEs due to enhanced permeability near faults. However, in the months following an SSE, healing in the prism will lower permeability, forcing pore pressure to rise and a new SSE to occur.
Spatial Relationships Between Coseismic Slip, Aseismic Afterslip, and On‐Fault Aftershock Density in Continental Earthquakes
Authors: Churchill R. M. , Werner M. J. , Biggs J. , Fagereng Å.
Published: January 2024

Damaging aftershock sequences often exhibit considerable spatio‐temporal complexity. The stress changes associated with coseismic slip and aseismic afterslip are commonly proposed to drive aftershock sequences, but few systematic studies exist and do not always support strong, universal driving relationships. To investigate the roles that these two sources of stress changes may play in driving aftershocks, we assess the spatio‐temporal relationships between coseismic slip, afterslip, and on‐fault (within 5 km) aftershock density following seven Mw6.0–7.6 continental‐settings earthquakes, using available high‐quality slip models and regional seismic data. From previous empirical work and frictional considerations, near the mainshock we expect coseismic slip and afterslip to be anti‐correlated, and aftershocks to occur where coseismic slip is low/zero, near high slip gradients, and/or to migrate with afterslip. However, we find that spatial relationships between afterslip and coseismic slip, and between afterslip and aftershock density differ between earthquakes. Aftershock density correlates with coseismic slip following five of the earthquakes, and with total cumulative slip (coseismic slip + afterslip) following six: indicating that on‐fault aftershock distributions may be approximated by total slip (at current resolutions). Additionally, we find that the gradients of coseismic slip and afterslip (proxies for new stress concentrations) do not clearly correlate with aftershock distributions and that the choice of spatial domain over which relationships are tested can affect results significantly. A possible explanation of these results is that fault zones contain considerable fine‐scale structural and frictional heterogeneity. Nonetheless, the empirical evidence for frequently assumed relationships between coseismic slip, afterslip and on‐fault aftershocks is mixed.
Potential of Earthquake Strong Motion Observation Utilizing a Linear Estimation Method for Phase Cycle Skipping in Distributed Acoustic Sensing
Authors: Katakami S. , Noda S. , Korenaga M. , Araki E. , Takahashi N. , Iwata N.
Published: January 2024

Distributed acoustic sensing (DAS) using existing optical fiber cables facilitates high‐density seismic observation. However, few studies have examined the reliability of the seismic waveform amplitude recorded by DAS. In this study, a DAS network was connected to optical fiber cables installed over a distance of 75 km along a high‐speed train (Shinkansen) railway in the Kumamoto prefecture, Japan. We successfully observed strong motions of the Mj6.6 earthquake (approximately 150 km from the fiber) on 22 January 2022, in Hyuga‐nada, in addition to several small local earthquakes. The observed strong motions from the Mj6.6 earthquake, using DAS, exhibited cycle skipping (clipping) issues due to dynamic range limitations at numerous channels. To address this, we estimated the shaking map, representing maximum strain distributions for Mj6.6, by replacing the clipped data with information from nearby unclipped channels and scaling their RMS amplitudes based on S‐coda (unclipped). Furthermore, we verified the reliability of the amplitude information obtained from DAS by estimating the distance attenuation of seismic waves while correcting for the differences in the structure type and coupling as much as possible. The distance attenuation property of local earthquakes was consistent with that of the peak ground velocities obtained from seismometers, indicating that DAS data acquired using fibers installed on infrastructure (various structures) can also be utilized to assess the spatial distribution of the relative amplitude values along the fiber. Obtaining high‐density seismic motion distributions is important for earthquake early warning and accurate damage estimation of strong motions.
Characterization of Submicron‐Thick Layered Structure in Hydrogenetic Ferromanganese Nodule Suggests Short‐Term Redox Fluctuation of Paleo‐Ocean
Authors: Zhou Junming , Kogure Toshihiro , Okumura Taiga , Takahashi Yoshio , Liu Jing , Yang Shengxiong , Yuan Peng
Published: January 2024

Ferromanganese (Fe‐Mn) nodules are widely considered significant economic potential and paleoenvironmentally significant archives. Generally, submicron‐thick layers (SMLs) are basic units of the Fe‐Mn nodules and record valuable information about the environment of Fe‐Mn nodule formation, but their structural, mineralogical, and chemical features are not well resolved. Here, we investigated a typical hydrogenetic Fe‐Mn nodule from the Penrhyn Basin in the South Pacific Ocean, using various microanalytical techniques. The nodule mainly consists of a micronodule‐dominant region around the core, a crust near the surface with Mn‐ and Fe‐rich layers, and stromatolite‐like textures between them. These textures are composed of distinct and indistinct SMLs parallel to their growth front. Although the distinct and indistinct SMLs have different mineral phases, the transmission electron microscopy revealed that these layered structures are actually interstratification of SMLs with different crystal sizes of foliated phyllomanganates. Large crystals contain higher Mn oxidation states than small crystals. Such variations of Mn oxidation state with different crystal sizes along the growth direction imply the short‐term regular fluctuation in the redox condition of the Lower Circumpolar Deep Water.
Contribution of Ship Emission to Volatile Organic Compounds Based on One‐Year Monitoring at a Coastal Site in the Pearl River Delta Region
Authors: Tong Mengxue , Zhang Yanli , Zhang Huiyi , Chen Duohong , Pei Chenglei , Guo Hao , Song Wei , Yang Xin , Wang Xinming
Published: January 2024

Ship emission impacts ambient air quality, especially in coastal regions, by emitting air pollutants such as fine particles, nitrogen oxides (NOx), and sulfur dioxide (SO2), yet its contributions to volatile organic compounds (VOCs) and the formation of secondary organic aerosol (SOA) and ozone (O3) are much less constrained with the challenge in distinguish ship emission from land diesel emission. In this study, we conducted a 1‐year online measurement of VOCs with a 1‐hr resolution at a coastal site in south China's Pearl River Delta region, which holds three of the world's top 10 container ports. The results revealed that C10–C12 n‐alkanes, as typical diesel‐related emission tracers, were significantly enhanced and strongly related to oceanic air masses. Receptor modeling revealed two diesel‐related sources of land diesel emission and ship emission, which could be differentiated based on their source profiles, seasonal trends and air mass back trajectories. Ship emissions contributed 6.4%, 5.0%, and 13.6% of total VOC mixing ratios, ozone formation potentials (OFPs), and secondary organic aerosol formation potentials (SOAFPs), while these percentages were 3.4%, 14.7%, and 15.9% for land diesel emission, respectively. In particular, in July, ship emissions could contribute 21.7%, 14.6%, and 31.2% of VOCs, OFPs, and SOAFPs, respectively. Our results highlight the important contribution of diesel‐related emission VOCs in forming O3 and SOA in coastal regions, and ship emission is a non‐negligible source of VOCs, particularly after the strict control of land emission sources.
Predicting Methane Formation Rates of Freshwater Sediments in Different Biogeographic Regions
Authors: Moras Simone , Zellmer Ursula Ronja , Hiltunen Evelina , Grasset Charlotte , Sobek Sebastian
Published: January 2024

Freshwater lakes and reservoirs cover a small fraction of the Earth, however their emission of the greenhouse gas methane (CH4) from the sediment to the atmosphere is disproportionately high. Currently, there is still a limited understanding of the links between sediment characteristics and CH4 formation. Earlier studies have indicated that sediment age and nitrogen content are related to sediment CH4 formation rates, but it is uncertain such relationships are valid across gradients of sediment characteristics. We therefore measured potential CH4 formation rates in multiple layers of sediment sampled from nine lakes situated in the temperate, boreal and alpine biogeographic regions of Sweden, thus differing in productivity, catchment and climate properties. Potential CH4 formation varied over 3 orders of magnitude, and was broadly related to the quantity and reactivity of organic matter, and generally decreased with sediment depth. Sediment age and total nitrogen content were found to be the key controlling factors of potential CH4 formation rates, together explaining 62% of its variability. Moreover, the model developed from the Swedish lake sediment data was able to successfully predict the potential CH4 formation rates in reservoirs situated in different biogeographic regions of Brazil (R2 = 0.62). Therefore, potential CH4 formation rates in sediments of highly contrasting lakes and reservoirs, from Amazonia to alpine tundra, could be accurately predicted using one common model (RMSE = 1.6 in ln‐units). Our model provides a valuable tool to improve estimates of CH4 emission from lakes and reservoirs, and illustrates the fundamental regulation of microbial CH4 formation by organic matter characteristics.
Ocean Oxygen, Preformed Nutrients, and the Cause of the Lower Carbon Dioxide Concentration in the Atmosphere of the Last Glacial Maximum
Authors: Sigman Daniel M. , Hain Mathis P.
Published: January 2024

All else equal, if the ocean's “biological [carbon] pump” strengthens, the dissolved oxygen (O2) content of the ocean interior declines. Confidence is now high that the ocean interior as a whole contained less oxygen during the ice ages. This is strong evidence that the ocean's biological pump stored more carbon in the ocean interior during the ice ages, providing the core of an explanation for the lower atmospheric carbon dioxide (CO2) concentrations of the ice ages. Vollmer et al. (2022, https://doi.org/10.1029/2021PA004339) combine proxies for the oxygen and nutrient content of bottom waters to show that the ocean nutrient reservoir was more completely harnessed by the biological pump during the Last Glacial Maximum, with an increase in the proportion of dissolved nutrients in the ocean interior that were “regenerated” (transported as sinking organic matter from the ocean surface to the interior) rather than “preformed” (transported to the interior as dissolved nutrients by ocean circulation). This points to changes in the Southern Ocean, the dominant source of preformed nutrients in the modern ocean, with an apparent additional contribution from a decline in the preformed nutrient content of North Atlantic‐formed interior water. Vollmer et al. also find a lack of LGM‐to‐Holocene difference in the preformed 13C/12C ratio of dissolved inorganic carbon. This finding may allow future studies to resolve which of the proposed Southern Ocean mechanisms was most responsible for enhanced ocean CO2 storage during the ice ages: (a) coupled changes in ocean circulation and biological productivity, or (b) physical limitations on air‐sea gas exchange.
Neural correlates of automatic emotion regulation and their association with suicidal ideation in adolescents during the first 90-days of residential care
Authors: Dobbertin Matthew , Blair Karina S. , Aloi Joseph , Bajaj Sahil , Bashford-Largo Johannah , Mathur Avantika , Zhang Ru , Carollo Erin , Schwartz Amanda , Elowsky Jaimie , Ringle J. L. , Tyler Patrick , Blair R. James
Published: January 2024

Background: Suicide is the second leading cause of death for adolescents in the United States. However, relatively little is known about the forms of atypical neuro-cognitive function that are correlates of suicidal ideation (SI). One form of cognitive/affective function that, when dysfunctional, is associated with SI is emotion regulation. However, very little work has investigated the neural correlates of emotion dysregulation in adolescents with SI. Methods: Participants (N = 111 aged 12-18, 32 females, 31 [27.9%] reporting SI) were recruited shortly after their arrival at a residential care facility where they had been referred for behavioral and mental health problems. Daily reports of SI were collected during the participants’ first 90-days in residential care. Participants were presented with a task-fMRI measure of emotion regulation – the Affective Number Stroop task shortly after recruitment. Participants were divided into two groups matched for age, sex and IQ based on whether they demonstrated SI. Results: Participants who demonstrated SI showed increased recruitment of regions including dorsomedial prefrontal cortex/supplemental motor area and parietal cortex during task (congruent and incongruent) relative to view trials in the context of emotional relative to neutral distracters. Conclusions: Participants with SI showed increased recruitment of regions implicated in executive control during the performance of a task indexing automatic emotion regulation. Such data might suggest a relative inefficiency in the recruitment of these regions in individuals with SI.
The role and applications of extracellular vesicles in osteoporosis
Authors: Fang Fei , Yang Jie , Wang Jiahe , Li Tiantian , Wang Erxiang , Zhang Demao , Liu Xiaoheng , Zhou Chenchen
Published: January 2024

Osteoporosis is a widely observed condition characterized by the systemic deterioration of bone mass and microarchitecture, which increases patient susceptibility to fragile fractures. The intricate mechanisms governing bone homeostasis are substantially impacted by extracellular vesicles (EVs), which play crucial roles in both pathological and physiological contexts. EVs derived from various sources exert distinct effects on osteoporosis. Specifically, EVs released by osteoblasts, endothelial cells, myocytes, and mesenchymal stem cells contribute to bone formation due to their unique cargo of proteins, miRNAs, and cytokines. Conversely, EVs secreted by osteoclasts and immune cells promote bone resorption and inhibit bone formation. Furthermore, the use of EVs as therapeutic modalities or biomaterials for diagnosing and managing osteoporosis is promising. Here, we review the current understanding of the impact of EVs on bone homeostasis, including the classification and biogenesis of EVs and the intricate regulatory mechanisms of EVs in osteoporosis. Furthermore, we present an overview of the latest research progress on diagnosing and treating osteoporosis by using EVs. Finally, we discuss the challenges and prospects of translational research on the use of EVs in osteoporosis.
Influence of the patient’s age on the safety, efficacy, and prediction accuracy of the microkeratome in laser-assisted in situ keratomileusis
Authors: Benabidi Safiya , Frings Andreas , Druchkiv Vasyl , Katz Toam
Published: January 2024

The purpose of this retrospective pseudonymised data analysis was to determine whether the patient’s age has an influence on the safety, efficacy, and prediction accuracy of laser in situ keratomileusis (LASIK) treatment of myopic and hyperopic eyes. This study was performed at CARE Vision GmbH (Düsseldorf, Germany) and included two patient cohorts: an older group with patients > 55 years old and a younger group with patients 30–40 years old. Each patient had a single LASIK treatment. The safety, efficacy, and prediction accuracy of the refractive results were analysed. In total, 682 patients were analysed, with 341 patients in each patient group (one eye per patient). There were 570 myopic eyes and 112 hyperopic eyes. In myopic eyes, the efficacy was significantly influenced by the patient’s age but only in myopic eyes (myopic: p ≤ 0.05; hyperopic: p = 0.085), while safety was not significantly influenced by the patient’s age in hyperopic or myopic eyes (p = 0.204). We found that LASIK treatment at an older age (> 55 years) resulted in almost the same safety outcomes as a LASIK treatment at a younger age (30–40 years) but with a lower efficacy; the efficacy correlated with the patient’s age. If the patient was hyperopic, their age did not influence safety or efficacy.
Association between systemic immune-inflammation index and insulin resistance and mortality
Authors: Deng Xiaoqi , Liu Dichuan , Li Miao , He Jie , Fu Yufan
Published: January 2024

The role of inflammation in disease promotion is significant, yet the precise association between a newly identified inflammatory biomarker and insulin resistance (IR) and mortality remains uncertain. We aim to explore the potential correlation between systemic immune-inflammation index (SII) and these factors. We used data from 2011 to 2016 of National Health and Nutrition Examination Survey, and multivariate logistic regression and restricted cubic spline were employed. Subgroup and interaction analysis were conducted to recognize the consistency of the results. The association between SII and mortality was described by survival analysis. 6734 participants were enrolled, of whom 49.3% (3318) exhibited IR and 7.02% experienced mortality. Multivariate logistic regression revealed that individuals in the highest quartile (Q4) of SII had a significantly increased risk of IR compared to those in the lowest quartile (Q1). We then identified a linear association between SII and IR with an inflection point of 407, but may be influenced by gender. Similarly, compared to Q1, people whose SII at Q4 showed a higher all-cause and cardiovascular mortality. It showed a significant association between SII and both all-cause and cardiovascular mortality, but the results need to be interpreted with caution.
Assessing generalisability of deep learning-based polyp detection and segmentation methods through a computer vision challenge
Authors: Ali Sharib , Ghatwary Noha , Jha Debesh , Isik-Polat Ece , Polat Gorkem , Yang Chen , Li Wuyang , Galdran Adrian , Ballester Miguel-Ángel González , Thambawita Vajira , Hicks Steven , Poudel Sahadev , Lee Sang-Woong , Jin Ziyi , Gan Tianyuan , Yu ChengHui , Yan JiangPeng , Yeo Doyeob , Lee Hyunseok , Tomar Nikhil Kumar , Haithami Mahmood , Ahmed Amr , Riegler Michael A. , Daul Christian , Halvorsen Pål , Rittscher Jens , Salem Osama E. , Lamarque Dominique , Cannizzaro Renato , Realdon Stefano , de Lange Thomas , East James E.
Published: January 2024

Polyps are well-known cancer precursors identified by colonoscopy. However, variability in their size, appearance, and location makes the detection of polyps challenging. Moreover, colonoscopy surveillance and removal of polyps are highly operator-dependent procedures and occur in a highly complex organ topology. There exists a high missed detection rate and incomplete removal of colonic polyps. To assist in clinical procedures and reduce missed rates, automated methods for detecting and segmenting polyps using machine learning have been achieved in past years. However, the major drawback in most of these methods is their ability to generalise to out-of-sample unseen datasets from different centres, populations, modalities, and acquisition systems. To test this hypothesis rigorously, we, together with expert gastroenterologists, curated a multi-centre and multi-population dataset acquired from six different colonoscopy systems and challenged the computational expert teams to develop robust automated detection and segmentation methods in a crowd-sourcing Endoscopic computer vision challenge. This work put forward rigorous generalisability tests and assesses the usability of devised deep learning methods in dynamic and actual clinical colonoscopy procedures. We analyse the results of four top performing teams for the detection task and five top performing teams for the segmentation task. Our analyses demonstrate that the top-ranking teams concentrated mainly on accuracy over the real-time performance required for clinical applicability. We further dissect the devised methods and provide an experiment-based hypothesis that reveals the need for improved generalisability to tackle diversity present in multi-centre datasets and routine clinical procedures.
A longitudinal field study of commercial honey bees shows that non-native probiotics do not rescue antibiotic treatment, and are generally not beneficial
Authors: Anderson Kirk E. , Allen Nathan O. , Copeland Duan C. , Kortenkamp Oliver L. , Erickson Robert , Mott Brendon M. , Oliver Randy
Published: January 2024

Probiotics are widely used in agriculture including commercial beekeeping, but there is little evidence supporting their effectiveness. Antibiotic treatments can greatly distort the gut microbiome, reducing its protective abilities and facilitating the growth of antibiotic resistant pathogens. Commercial beekeepers regularly apply antibiotics to combat bacterial infections, often followed by an application of non-native probiotics advertised to ease the impact of antibiotic-induced gut dysbiosis. We tested whether probiotics affect the gut microbiome or disease prevalence, or rescue the negative effects of antibiotic induced gut dysbiosis. We found no difference in the gut microbiome or disease markers by probiotic application or antibiotic recovery associated with probiotic treatment. A colony-level application of the antibiotics oxytetracycline and tylosin produced an immediate decrease in gut microbiome size, and over the longer-term, very different and persistent dysbiotic effects on the composition and membership of the hindgut microbiome. Our results demonstrate the lack of probiotic effect or antibiotic rescue, detail the duration and character of dysbiotic states resulting from different antibiotics, and highlight the importance of the gut microbiome for honeybee health.
Complementary nutritional and health promoting constituents in germinated and probiotic fermented flours from cowpea, sorghum and orange fleshed sweet potato
Authors: Kewuyemi Yusuf Olamide , Adebo Oluwafemi Ayodeji
Published: January 2024

Germination and fermentation are age-long food processes that beneficially improve food composition. Biological modulation by germination and probiotic fermentation of cowpea, sorghum, and orange-fleshed sweet potato (OFSP) and subsequent effects on the physicochemical (pH and total titratable acidity), nutritional, antinutritional factors and health-promoting constituents/properties (insoluble dietary fibres, total flavonoid and phenolic contents (TFC and TPC) and antioxidant capacity) of the derived flours were investigated in this study. The quantification of targeted compounds (organic acids and phenolic compounds) on an ultra-high performance liquid chromatography (UHPLC) system was also done. The whole cowpea and sorghum were germinated at 35 °C for 48 h. On the other hand, the milled whole grains and beans and OFSP were fermented using probiotic mesophilic culture at 35 °C for 48 h. Among the resultant bioprocessed flours, fermented sorghum and sweet potato (FSF and FSP) showed mild acidity, increased TPC, and improved ferric ion-reducing antioxidant power. While FSF had better slowly digestible and resistant starches and the lowest oxalate content, FSP indicated better hemicellulose, lowest fat, highest luteolin, caffeic and vanillic acids. Germinated cowpea flour exhibited reduced tannin, better lactic acid, the highest crude fibre, cellulose, lignin, protein, fumaric, l-ascorbic, trans-ferulic and sinapic acids. The comparable and complementary variations suggest the considerable influence of the substrate types, followed by the specific processing-based hydrolysis and biochemical transitions. Thus, compositing the bioprocessed flours based on the unique constituent features for developing functional products from climate-smart edibles may partly be the driver to ameliorating linked risk factors of cardiometabolic diseases.
Assessment of hydrogen peroxide as a bioindicator of stress in seaweed aquaculture
Authors: Taenzer Lina , Toth Gunilla , Hansel Colleen M.
Published: January 2024

The rapid expansion in commercial seaweed farming has highlighted the need for more effective monitoring methods, and health diagnostics. The production of the reactive oxygen species (ROS) hydrogen peroxide (H2O2) is a trait that is tied to all major macroalgal groups and holds significance both for its involvement in the oxidative stress response and in the production of climatically relevant gases such as halocarbons. Observations of increased production of H2O2 by plants as a stress response, along with its comparative stability and ease of quantification in seawater in comparison to other ROS, suggest that H2O2 could be used as an indicator of health. In this study we characterized aqueous H2O2 dynamics across a diel cycle, in response to small shifts in light and temperature, as well as when exposed to acute stress. Our results reveal that exposure to acute stressors leads to rapid and sustained concentrations of H2O2 that are orders of magnitude higher than changes in H2O2 concentrations observed throughout the day. These findings provide tantalizing evidence that monitoring H2O2 could be used as a health indicator in seaweed aquaculture and serve as an early warning sign of stress.
Dyeing of advanced denim fabrics (blend of cotton/bicomponent polyester filaments) using different processes and artificial intelligence method
Authors: Souissi Marwa , Chaouch Sabrine , Moussa Ali , Dhaouadi Hatem
Published: January 2024

Denim clothes are the must-have items of clothing around the world. This kind of fabrics is evolving with the increasing consumer demand in order to keep its place as a versatile article. In this context, this paper contributes to the development and dyeing of a new blend fabric made of cotton fibers and bicomponent polyester filaments (PET/PTT). A comparative study between the mechanical and thermal properties of this fabric and conventional fabrics has confirmed the great interest to use bicomponent (PET/PTT) filaments in the manufacture of denim fabrics; these bicomponent filaments allow to give to wearer the desired elasticity and comfort. For dyeing (cotton/bicomponent polyester filaments) blend fabric, three different processes, using reactive and disperse dyes, were tested and analyzed. These dyeing processes are: two-baths/two-phases, one-bath/two-phases, and one-bath/one-phase processes. In addition, in order to obtain uniform shades between cotton fibers dyed with reactive dyes and bicomponent polyester filaments dyed with disperse dyes, an ant colony algorithm was elaborated to predict the optimal dye recipes. By observing obtained results, the developed algorithm is very effective; it allows to find the combination of reactive dyes necessary to achieve the same shade obtained by the disperse dyes with very small color differences between the two components and without having to make corrections mainly for the one-bath/two-phases process. Indeed, dyeing using the two processes (two baths/two phases and one bath/two phases) presents the best values of color yield (K/S) with almost similar results (ΔECMC(2:1) <  < 1). For the one-bath/one-phase process, it presents less significant results; We can observe ΔECMC(2:1) greater than 1 in certain shades. This is due to the strongly pH value (basic pH of 11) of reactive dyeing.
Visualization analysis of research progress for walkability
Authors: Li Xuan , Xie Dan , Zhou Zhiyu , Zhang Xin , Li Rui , Li Jiayi , Chen Zeyu , Zhang Jiayu
Published: January 2024

The study of walkability is of great significance to the construction of healthy cities. In this paper, taking 1283 articles of walkability, which were included in Web of Science, as the research object. This paper adopts to analysis the research progress by using the method of scientometrics and knowledge networks analysis. Objectively and systematically analyze the research progress of walkability abroad from the aspects of publication overview, knowledge foundation, research direction and hot spots, etc. It is found that foreign researches on walkability mainly include three core directions: walkability and physical activity, walkability evaluation, walkability and urban design. Among them, walkability and physical activity orientation have been studied from various perspectives, such as various groups, various environmental types, different behavioral patterns and various chronic diseases. With the increasingly prominent urbanization problems and the rapid development of new technologies, multiple data, new methods and interdisciplinary cooperation will actively promote the vigorous development of walking suitability research.
A coarse-to-fine point completion network with details compensation and structure enhancement
Authors: Miao Yongwei , Jing Chengyu , Gao Weihao , Zhang Xudong
Published: January 2024

Point cloud completion, the issue of estimating the complete geometry of objects from partially-scanned point cloud data, becomes a fundamental task in many 3d vision and robotics applications. To address the limitations on inadequate prediction of shape details for traditional methods, a novel coarse-to-fine point completion network (DCSE-PCN) is introduced in this work using the modules of local details compensation and shape structure enhancement for effective geometric learning. The coarse completion stage of our network consists of two branches—a shape structure recovery branch and a local details compensation branch, which can recover the overall shape of the underlying model and the shape details of incomplete point cloud through feature learning and hierarchical feature fusion. The fine completion stage of our network employs the structure enhancement module to reinforce the correlated shape structures of the coarse repaired shape (such as regular arrangement or symmetry), thus obtaining the completed geometric shape with finer-grained details. Extensive experimental results on ShapeNet dataset and ModelNet dataset validate the effectiveness of our completion network, which can recover the shape details of the underlying point cloud whilst maintaining its overall shape. Compared to the existing methods, our coarse-to-fine completion network has shown its competitive performance on both chamfer distance (CD) and earth mover distance (EMD) errors. Such as, the repairing results on the ShapeNet dataset of our completion network are reduced by an average of$$35.62\%$$35.62%,$$33.31\%$$33.31%,$$29.62\%$$29.62%, and$$23.62\%$$23.62%in terms of CD error, comparing with PCN, FoldingNet, Atlas, and CRN methods, respectively; and also reduced by an average of$$15.63\%$$15.63%,$$1.29\%$$1.29%,$$64.52\%$$64.52%, and$$62.87\%$$62.87%in terms of EMD error, respectively. Meanwhile, the completion results on the ModelNet dataset of our network have an average reduction of$$28.41\%$$28.41%,$$26.57\%$$26.57%,$$20.65\%$$20.65%, and$$18.55\%$$18.55%in terms of CD error, comparing to PCN, FoldingNet, Atlas, and CRN methods, respectively; and also an average reduction of$$21.91\%$$21.91%,$$19.59\%$$19.59%,$$43.51\%$$43.51%, and$$21.49\%$$21.49%in terms of EMD error, respectively. Our proposed point completion network is also robust to different degrees of data incompleteness and model noise.
A Late Pleistocene hominin footprint site on the North African coast of Morocco
Authors: Sedrati Mouncef , Morales Juan A. , Duveau Jérémy , M’rini Abdelmounim El , Mayoral Eduardo , Díaz‐Martínez Ignacio , Anthony Edward J. , Bulot Glen , Sedrati Anass , Le Gall Romain , Santos Ana , Rivera-Silva Jorge
Published: January 2024

Footprints represent a relevant vestige providing direct information on the biology, locomotion, and behaviour of the individuals who left them. However, the spatiotemporal distribution of hominin footprints is heterogeneous, particularly in North Africa, where no footprint sites were known before the Holocene. This region is important in the evolution of hominins. It notably includes the earliest currently known Homo sapiens (Jebel Irhoud) and the oldest and richest African Middle Stone Age hominin sites. In this fragmented ichnological record, we report the discovery of 85 human footprints on a Late Pleistocene now indurated beach surface of about 2800 m2 at Larache (Northwest coast of Morocco). The wide range of sizes of the footprints suggests that several individuals from different age groups made the tracks while moving landward and seaward across a semi-dissipative bar-trough sandy beach foreshore. A geological investigation and an optically stimulated luminescence dating of a rock sample extracted from the tracksite places this hominin footprint surface at 90.3 ± 7.6 ka (MIS 5, Late Pleistocene). The Larache footprints are, therefore, the oldest attributed to Homo sapiens in Northern Africa and the Southern Mediterranean.