bluuebunny/crossref_metadata_2025 huggingface dataset:
Unveiling the Landscape of Toll-Like Receptors in Cognitive Dysfunction: A Bibliometric Analysis
Authors: Li Qi , Wang Huaiming , zhang Aimin
Published: July 2024

OBJECTIVES
Toll-like receptors (TLRs) are transmembrane proteins primarily involved in the immune response, mediating the pathophysiological process of cognitive impairment through pathways. Despite an abundance of literature elucidating the role of TLRs in cognitive dysfunction, bibliometric analyses of this topic are notably scarce.
METHODS
We conducted a bibliometric analysis of publications spanning from 2002 to 2023, retrieved from the widely utilized Web of Science Core Collection, employing tools such as R language, CiteSpace software, and the online bibliometric platform (https://bibliometric.com/) for a comprehensive visual analysis. Data analysis was performed using GraphPad Prism and IBM SPSS.
RESULTS
Our findings revealed a total of 502 articles published over the past 11 years. Notably, China contributed significantly, accounting for 39.84% (n = 200) of the publications, underscoring its prominence in this field. The Journal of Brain Behavior and Immunity emerged as the leading journal in terms of article contributions, with 40 publications (7.07%). Author influence, measured by the H-index, highlighted Baluchnejadmojarad, Tourandokht, and Roghani, Mehrdad, as the two most influential authors, each with an H-index of 9. The co-occurrence analysis of keywords revealed that terms such as "activation", "toll-like receptors", and "inflammation" were consistently prevalent in the literature.
CONCLUSION
This visualized bibliometric analysis demonstrated the progress in research related to TLRs in cognitive dysfunction, with a gradual increase in literature volume over the past 11 years. Researchers can derive valuable insights into research trends, frontiers, and influential authors from our study, aiding them in shaping their future research endeavors in this field.
High performance gold-nanowires-coated PCF-SPR sensor for refractive index detection
Authors: Liu Jiayuan , Dong Jie , Liu Qingmin , Hou Shanglin , Wu Gang , Yan Zuyong
Published: July 2024

A novel refractive index sensor based on surface plasmon resonance (SPR) of an excentric-core photonic crystal optical fiber (PCF) is proposed, whose cladding consists of air holes of two sizes and double gold nanowires are coated on its outer surface. The air hole diameter and spacing, gold-nanowire diameter are optimized respectively to obtain the optimal sensing performance by using the finite element method (FEM). The results indicate that the proposed ex-centric core PCF-SPR sensor with the gold nanowire diameter of 0.9 µm can detect refractive index of 1.34 ~ 1.39 in the wavelength range of 600 ~ 1500 nm with the maximum wavelength sensitivity of 51200 nm/RIU, amplitude sensitivity of -1248.5 RIU− 1, minimum resolution of 1.95×10− 6 RIU and optimal FOM of 179.33 RIU− 1. The PCF-SPR has potential applications including temperature measurement, organic chemical detection, medical detection, biomolecular detection and so on.
Study on The Response of Yield to Photosynthetic Characteristics under Apple-Watermelon Combined Planting Mode
Authors: ZHANG Pei-pei , Song-tao LIU , El-SAWY S M , DING Xiao-mei , Xiao-hu MA , Chao-fan WEI , ZHANG Zhi-xiang , ZHANG Wei , LI Qian
Published: July 2024

Agroforestry changes the traditional land use mechanism and has the advantage of intensive eco-economic compound. The photosynthetic characteristics of planting areas are the driving and restricting factors for the accumulation of plant material conversion. To investigate the response of the yield of apple-watermelon intercropping and the yield of fruit trees and crops to photosynthetic characteristics, the growth indexes, photosynthetic characteristics, yield, and benefits of single apple (CK1), single watermelon (CK2) and compound cropping modes were studied respectively. The results showed that the final growth indexes of intercropping apples were higher than those of the single model. However, due to the shading effect of high fruit trees on low crops, the normal growth of watermelon was inhibited, and the growth level of intercropping watermelon was lower than that of single mode. The Pn of apples and watermelons in different planting patterns showed a bimodal trend, and reached the peak value between 10:00–12:00 and 14:00–16:00. The daily variation curve of PAR showed an unimodal trend, and the peak value of apples and watermelons under the two planting patterns appeared between 12:00–14:00 and 10:00–12:00, respectively. Compound planting benefited apples from higher Pn and PAR, and vice versa for watermelon. The diurnal variation of Gs and Tr of intercropping and single species of apple and watermelon first increased and then decreased in an inverted V pattern, the diurnal variation trend of Ci showed a V pattern. The Gs, Tr, and Ci of apple in compound mode were higher than that of watermelon in single mode. The yield of apples increased by 46.34% in the combined apple-watermelon planting mode, and the yield of the combined planting mode was significantly higher than that of the single planting mode due to the advantage of the unit price of apples. In the apple-watermelon compound planting model, the total income was 5.19×105 yuan /hm2, the income of the single apple model was 2.46×105 yuan /hm2, and the income of the single watermelon model was 1.85×105 yuan /hm2. The land utilization rate was 232.20% and the income utilization efficiency was 210.98%.
Formation and pinch-off of leading vortex ring in starting jets with uniform background crossflow
Authors: Zhao Ruijia , Zhang Guoqing , Zhu Jianwei , Yu S.C.M.
Published: July 2024

The formation and pinch-off of leading vortex ring in the starting jets with uniform background crossflow have been investigated numerically for Rv from 3 to 12and ∞,where Rv is the ratio of the jet velocity Uj to the velocity of background crossflow Uc. Rv = ∞ represents the case without any background crossflow. The background crossflow disrupts the symmetry in the formation process of leading vortex ring, causing it to move laterally and the circulation strength on either side of it to be unequal. The difference in the circulation strength can be normalized based on slug model. The lateral movement introduced by crossflow is found to be inversely proportional to Rv,but directly proportional to Uc at aconstant Uj. A kinematic model based on the lateral movement of leading vortex ring is established to characterize the pinch-off process in the starting jet with background crossflow. The occurrence of pinch-off at Rv ≥ 12 remains consistent with that without background crossflow, i.e., the formation number F remains constant with Rv. As for smaller Rv (less than 12), F increases linearly with Rv,i.e., F ∼ C2Rv,where C2 is a constant.
TGFB2-AS1 binding to MED1 promotes doxorubicin-induced cardiomyocyte apoptosis via BMP7 pathway
Authors: Gao Hailan , Lan Kai , Peng Fei , Lian Xiaoyu , Li Juexing , Zhou Lei , Gong Hui
Published: July 2024

Doxorubicin-induced cardiotoxicity (DIC) is similar to dilated cardiomyopathy (DCM) in morphological and functional defects, eventually progressing to heart failure. Recently, intensive investigation showed that specific expression profiles of lncRNA have been closely related to cardiovascular disease, but many gaps remain, including the emerging roles of lncRNA in DIC. We identified TGFB2-AS1 as a highly conserved regulator of DCM by reanalyzing publicly available RNA sequencing datasets from GEO and producing conservation scores of lncRNAs using PHAST software. TGFB2-AS1 expression is dramatically increased in murine and cell models, and TGFB2-AS1 has a pro-apoptotic effect in vitro. Moreover, TGFB2-AS1 mediated apoptosis via the BMP7 pathway by activating the Smad1/5/9 phosphorylation to upregulate the target gene expression Id2. Recombinant human bone morphogenetic protein (rhBMP-7) aggravates doxorubicin-induced cardiomyocyte apoptosis, and knockdown of BMP7 significantly reverses the pro-apoptotic effect of TGFB2-AS1 overexpression in vitro. Mechanistically, we found that TGFB2-AS1 combines with transcriptional co-activator MED1, promoting H3K27 acetylation modification level in the promoter of the BMP7 gene and then facilitating BMP7 transcription. Collectively, this study illuminates that TGFB2-AS1 is an evolutionarily conserved long noncoding RNA with a previously unappreciated role in promoting the apoptotic phenotype of DIC and sheds light on the more effective clinical application of doxorubicin.
Causality of genetically determined metabolites and metabolic pathways on asthenia: a two-sample Mendelian randomization study
Authors: Jing Wendan , Jia Qinyao , Wu Xiufei , He Jinsong , Jian Changchun
Published: July 2024

Objectives
Previous studies attempted to relieve drug-related asthenia by analyzing the blood metabolites. Metabolism as a potential mechanism of asthenia may be a clue for developing effective prevention and treatment methods. This study aimed to explore the causal relationship of metabolites or metabolic pathways to asthenia.
Methods
We adopted single nucleotide polymorphisms (SNPs) as genetic instruments to evaluate the levels of 486 circulating metabolites. These SNPs were obtained from large-scale genome-wide association studies originating from Europe. We investigated the causal impact of genetically predicted circulating metabolites on asthenia by a two-sample Mendelian randomization (MR) analysis. The sensitivity analysis estimated the reliability of the results, containing MR-Egger, weighted median, and weighted mode. Every one standard deviation (SD) elevation in exposure was revealed as odds ratios (OR) with 95% confidence intervals (CIs).
Results
After screening 486 circulating metabolites in this MR, we identified a causal relationship between 17 metabolites and asthenia. Among which bilirubin Z (IVW OR = 0.956; 95% CI: 0.934–0.979; P < 0.01), myristoleate (OR = 0.903; 95% CI: 0.822–0.993; P = 0.035), N-acetylalanine (OR = 0.961; 95% CI: 0.938–0.985; P = 0.001), threonate (OR = 0.922; 95% CI: 0.857–0.991; P = 0.028), 1-methylxanthine (OR = 0.917; 95% CI: 0.859–0.978; P = 0.009) were causally associated with reduced risk of asthenia. Arachidonate (OR = 1.305; 95% CI: 1.165–1.462; P < 0.01), kynurenine (OR = 1.204; 95% CI: 1.067–1.359; P = 0.003), lysine (OR = 1.335; 95% CI: 1.116–1.597; P = 0.002), octadecanedioate (OR = 1.121; 95% CI: 1.041–1.208; P = 0.003), oleoylcarnitine (OR = 1.161; 95% CI: 1.015–1.329; P = 0.030), palmitoleate (OR = 1.231; 95% CI: 1.023–1.480; P = 0.028), stearoylcarnitine (OR = 1.194; 95% CI: 1.042–1.369; P = 0.011), thymol sulfate (OR = 1.035; 95% CI: 1.011–1.059; P = 0.004), valine (OR = 2.042; 95% CI: 1.400-2.979; P < 0.01), 3-dehydrocarnitine (OR = 1.182; 95% CI: 1.076-1.300; P < 0.01), 4-methyl-2-oxopentanoate (OR = 1.235; 95% CI: 1.009–1.511; P = 0.040), 4-vinylphenol sulfate (OR = 1.098; 95% CI: 1.046–1.153; P < 0.01) were related to a higher risk of asthenia. This result is not affected by heterogeneity and horizontal pleiotropy. Metabolic pathway analysis suggested three pathways that probably correlated to asthenia, they were “Glycine, serine and threonine metabolism (P = 0.00174)”, “Glycerophospholipid metabolism (P = 0.0304)”, “Phenylalanine, tyrosine and tryptophan biosynthesis (P = 0.0309)”.
Conclusions
This MR study discovered a causal effect of blood metabolites on the asthenia risk. These metabolites and metabolic pathways can be applied in asthenia prevention and treatment strategies.
Ultrastable Fe-N4-C6O2 Single Atom Sites for Highly Efficient PMS Activation and Enhanced FeIV=O Reactivity
Authors: Zhang Lizhi , Chen Tiantian , Zhang Ganbing , Sun Hongwei , Hua Yetong , Yang Shu , Zhou Dandan , Di Haoxin , Xiong Yiling , Hou Shenghuai , Xu Hui
Published: July 2024

The local environment modulation of iron sites in Fe-N4 single atom catalysts (SACs) plays a crucial role in the efficient peroxymonosulfate (PMS) activation. Many reported modulation strategies involve the partial replacement of N in the first coordination shell of Fe-N4 sites with foreign elements to facilitate the PMS activation via disrupting the structural symmetry, suffering from undesired catalytic stability. Herein, we demonstrate that Fe-N4-C6O2 sites, which are prepared by substituting C in the second coordination shell of Fe-N4 sites with O, can activate PMS more efficiently and stably by providing an enhanced localized electric field without destroying their symmetric coordination structure in the first coordination shell, and thus achieve an unprecedented catalytic durability of at least 240 h. The O doping in the second coordination shell strengthened the Fe-N bond by reducing the electron density of Fe center, and weakened the amplitude of Fe-N bond from 0.875 ~ 3.175 Å to 0.925 ~ 2.975 Å during the PMS activation, therefore effectively prevented the demetallation of Fe-N4 sites. Meanwhile, this O doping also lowered the energy of Fe = O σ* orbitals by weakening the coordination field to promote the electrophilic σ-attack of high-valent iron-oxo (FeIV=O) towards electron-rich contaminants, thus enhancing the bisphenol A degradation rate from 1.08 × 103 M− 1 s− 1 to 4.6 × 104 M− 1 s− 1 by a factor of 41.6. This work sheds light on the importance of second coordination shell doping on the ultrastability of Fe-N4 SACs, and provides a novel strategy to design metal SACs by balancing a trade-off between exceptional activity and long-term stability.
Effectiveness of Compassion-Therapy Training on Suicidal Thoughts of Female Adolescents
Authors: Davudi Hossein , Sobhani Sogand , Motlagh Maryam ghasemi
Published: July 2024

The present research was conducted aiming at the effectiveness of compassion-therapy training on suicidal thoughts of adolescent girls. The present research methodology was an experiment with a pre-test, post-test design with a control group. The statistical population of the research included 33 female adolescent students from three second secondary schools in Khomein County in the academic year of 2022–2023, who had a history of self-harm and were referred to Education Counseling Center. Out of this number, 20 students were selected by simple random sampling method and randomly divided into two 10-individual groups. The experimental group and the control group were determined randomly. The suicidal ideation scale of Erich et al. (1991) was used to gather the data. Gilbert's (2021) self-compassion training intervention was implemented in 8 training sessions for 90 minutes during a month (twice a week). One-way analysis of covariance test was used to analyze the data. The findings indicated that compassion-therapy training has been influential on adolescent girls' suicidal thoughts and this training has explained 70% of the variance of the suicidal thoughts. Based on the findings of this research, it can be concluded that the self-compassion-focused treatment is an effective strategy to help reduce the suicidal thoughts of adolescent girls.
Hydrous mantle melting controls gold enrichment in Kermadec arc magmas
Authors: Timm Christian , Portnyagin Maxim , de Ronde Cornel , Hannington Mark , Garbe-Schönberg Dieter , Hoernle Kaj , Brandl Philipp , Layton-Matthews Daniel , Leybourne Matthew , Arculus Richard
Published: July 2024

Many economic gold deposits on Earth are associated with volcanic arcs. However, little is known about the factors that control the gold endowment of the parental arc magmas. Here, we present new high-precision geochemical data from submarine glasses recovered from the length of the Kermadec arc. We show that the combined systematics of Au, Ag and Cu helps to decipher sources and processes responsible for Au enrichment in arc magmas. These data show that hydrous melting in the Kermadec subarc mantle occurs predominantely at high temperatures in the presence of sulfide liquid. The highest Au (>8 ppb at MgO> 5 wt.%), Au/Cu (up to 6*10-6) and mantle-like Ag/Cu values correspond to high-temperature second-stage melting. Elevated temperatures in a hydrous subarc mantle enables enhanced and multiple-stage melting of highly depleted mantle and thus is a prerequisite of Au enrichment in parental arc magmas.
A retrospective study on intestinal obstruction during the extended period from 2022 to 2024 in Al-moussat hospital-Damascus
Authors: Barkal Hanifi Hassan , Al-essa Mohammed Jamal , Al-sakaan Mohammed morhaf
Published: July 2024

Bowel obstruction is one of the emergency cases that require prompt intervention. It remains a challenging issue to surgeons due to many possible differential diagnoses [1]. This retrospective study was intended to highlight the common causes of intestinal obstruction. A total of 172 patients who were diagnosed with intestinal obstruction and were operated in the department of surgery in Al-mouassat hospital in Damascus from February 2022 to January 2024 were taken for this study and they were compared in terms of sex, age group, diagnostic tools, presenting symptoms, and treatment. In addition, we compared our study with another two studies regarding the same topic.
Orexinergic modulation of chronic jet lag-induced deficits in mouse cognitive flexibility
Authors: Fendt Markus , Duske Julius , D'Souza Nicole , Mayer Dana , Dieterich Daniela
Published: July 2024

Cognitive flexibility and working memory are important executive functions mediated by the prefrontal cortex and can be impaired by circadian rhythm disturbances such as chronic jet lag (CJL) or shift work. In the present study, we used mice to investigate whether (1) simulated CJL impairs cognitive flexibility, (2) the orexin system is involved in such impairment, and (3) nasal administration of orexin A is able to reverse CJL-induced deficits in cognitive flexibility and working memory. Mice were exposed to either standard light-dark conditions or simulated CJL consisting of series of advance time shifts. Experiment (1) investigated the effects of a mild CJL protocol on cognitive flexibility using the attentional set shifting task. Experiment (2) used a stronger CJL protocol and examined CJL effects on the orexin system utilizing c-Fos and orexin immunohistochemistry. Experiment (3) tested whether nasal orexin application can rescue CJL-induced deficits in cognitive flexibility and working memory, the latter by measuring spontaneous alternation in the Y-maze. The present data show that CJL (1) impairs cognitive flexibility and (2) reduces activity of orexin neurons in the lateral hypothalamus. (3) Nasal administration of orexin A rescued CJL-induced deficits in working memory and cognitive flexibility. These findings suggest that executive functions impairments by circadian rhythm disturbances such as CJL are caused by dysregulation of orexinergic input to the prefrontal cortex. Compensation of decreased orexinergic input by nasal administration of orexin A could be a potential therapy for CJL- or shift work-induced human deficits in executive functions.
Analysis of organophosphorus pesticide residue content in brinjal and cucumber vegetables in the Narsingdi district in Bangladesh
Authors: Mahjabin Tasnima , Razzak Md. Abdur , Rahman Matiur , Ahmmed Abu Noman Faruq , Ferdous Raihan
Published: July 2024

This study investigated the prevalence of organophosphorus (OPs) pesticide residues in brinjal (eggplant) and cucumber samples collected from Narsingdi District, Bangladesh, between September 2021 and June 2022. A total of 36 unwashed vegetable samples (18 from brinjals and 18 from cucumbers) were collected from three sources, namely, farmers' fields, retail markets, and a controlled export zone. The samples were analyzed for residues of four OPs pesticides, viz. Diazinon, Dimethoate, Malathion, and Chlorpyrifos, using the QuEChERS method followed by Gas Chromatography-Mass Spectrometry (GC/MS) technology. The results revealed a concerning level of pesticide contamination, particularly with Dimethoate. Over half (58%) of all the samples contained Dimethoate, more than one-third (39%) of which exceeded the European Union's Maximum Residue Limits (MRL). Chlorpyrifos was also detected in 50% of the samples, but only 8% of the samples exceeded the MRLs. Malathion residues were found in a small number of samples (11%), all within the MRLs. Notably, Diazinon was not detected in any of the samples. Cooking (boiling at 100°C for 30 minutes) reduced the pesticide content in some samples, but it was not always sufficient to bring the pesticide content below the MRLs. This highlights the limitations of cooking as a sole decontamination method. Encouragingly, no pesticide residues were found in samples collected from the export zone, suggesting stricter adherence to regulations in these controlled environments. These findings highlight the potential health risks associated with consuming vegetables contaminated with pesticide residues above the recommended limits. These factors emphasize the need for stricter regulations on pesticide use, the promotion of Integrated Pest Management (IPM) techniques, and consumer education on safe prewashing practices.
Prevalence of Color Vision Defects Among High School Students in Damascus, Syria
Authors: alhusain Yaman , Adal Lama Al , Almohsen Ammar , Issa Yaman , Almasri Imad-Addin , alhusain Hamza , Alhalabi Nawras , Haddeh Yousra
Published: July 2024

Introduction: A congenital color vision defect results from genetic mutations that affect the expression of normal cone photoreceptors. They are generally categorized by severity (abnormal trichromacy, binocular, and monocular vision) and may be further classified by the type of cones affected. Pathological trichromacy is the mildest form of color vision disorder. This case is divided into red, green, and blue. Pathological dichroic vision This condition is the most severe among color vision disorders. Dichromats have low levels of color vision and only two of the primary colors are seen. Dichroism is divided into red blindness, green blindness, and blue blindness—pathological monochromatic vision. The most severe form of congenital color vision deficiency results in a monochromatic condition, in which there is no color discrimination.
Methods: an observational study of the type of cross-sectional study. This study targeted randomly collected persons from high school students in the Syrian Arab Republic. When the sample was randomly selected, about (834) patients were selected who met specific acceptance criteria, while all patients were excluded according to specific exclusion criteria, using an AI online test.
Results: 54.8% of the participants were male and 45.2% were female, moreover 57% were 10th grade and 43% were 11th, 33.4% know CDV. Moreover, 2.6% have a family history of CDV. In our study, we found 3.9% Red-green type, 1% were proton and 2.9% were deuton.
Conclusion: We found a statistically significant difference between men and women in terms of color blindness, in addition, the kinship between parents plays an important role in the inheritance of color blindness, moreover, the presence of eye diseases increases the risk of color blindness, also having a family history of color blindness increases the risk of color blindness.
Production of Al-mg Alloy Deep Drawable Sheet by Twin Roll Casting Method Equivalent Quality to Direct Chill Casting
Authors: DÜNDAR KORAY , ALTUNCU EKREM , BİRBAŞAR ONUR
Published: July 2024

Aluminum alloys; they have a wide range of uses thanks to their good mechanical properties, recyclability, corrosion resistance and light weight. In deep drawable materials, 5xxx series (Al-Mg) aluminum alloys are preferred due to their high corrosion resistance as well as their shaping and good weldability. In this study, the chemical composition was designed and suitable thermomechanical processes were determined for the production of deep-drawable sheets by the Twin Roll Casting (TRC) method, which are equivalent to the deep-drawable 5xxx series Al-Mg alloy sheets produced by the Direct Cooling Casting (DCC) method supplied from abroad. Within the scope of the study, AA5182-AA5754-AA5052 alloys widely used in the 5xxx series alloy group were determined. Castings were made with the TRC method and sheets produced under the same conditions the DCC method were purchased. The microstructures of the sheets in the casting thickness were examined. Sheets were cold rolled to 1 mm thickness and the final annealing process was applied. Three-way (00, 450, 900) tensile tests were performed on the final thickness and O temper plates and yield strength, tensile strength, % elongation value, vertical and planar anisotropy values were found. Erichsen values were determined. Plates with deep drawing properties equivalent to the alloys produced by the DCC method have been successfully produced. Three deep-drawable alloys were developed with the TRC technique and it was determined that the TRC AA5182 alloy plate had the best deep-drawability.
Bibliografie der Übersetzungen von Cäcilie Heinig
Authors: Möllring Christina
Published: July 2024

In der vorliegenden Bibliografie werden in der Rubrik "Übersetzungen in Buchform" Einzelausgaben und die daraus hervorgegangenen Sammelausgaben, die mehrere Werke enthalten, separat aufgeführt. Die Kategorie "Sonstige Übersetzungen" umfasst Bilderbuchversionen, Hörspiele sowie spätere Publikationen, die auf Cäcilie Heinigs Übersetzungen zurückgreifen.
Fritz Heymann, 1897–1944
Authors: Kelletat Andreas F.
Published: July 2024

Unter den Exilbeständen der Deutschen Nationalbibliothek finden sich an beiden Standorten (Leipzig und Frankfurt/M.) vier von Fritz Heymann aus dem Englischen übersetzte und in Amsterdam zwischen 1937 und 1940 veröffentlichte Sachbücher mit einem Gesamtumfang von knapp 1700 Druckseiten.
Supply Chain Sustainability Measurement in Telecommunications Industry in Indonesia
Authors: Nabil Abdullah , Asrol Muhammad
Published: July 2024

In the fiercely competitive telecommunications industry of Indonesia, the significance of innovation and perpetual improvement cannot be underestimated. It is imperative for businesses to explore the potential of sustainable supply chain management, as it allows for the integration of environmental, economic, and social dimensions. By implementing a comprehensive and thorough approach, this study offers a theoretical framework for measuring sustainable supply chain performance. Through qualitative and quantitative methods, you'll be able to identify the attributes that greatly impact the success of your sustainable supply chain management. On this research Analytic Hierarchy Process (AHP) utilize to define Consistency Ratio (CR) and weight between dimension using SuperDecisions software. Then, Multidimensional Scaling (MDS) is utilized to measure performance of supply chain sustainability. At the same time, a stress value also measured to indicate the sustainability measurement of one specific dimension is sufficient in accordance with existing condition or not. Next, to better indicate which attributes are most influential on improving dimensional sustainability performance, it is essential to conduct a sensitivity analysis and Montecarlo analysis for each attribute. In the end, this research successfully determined which attributes that influence sustainable supply chain management and measure the value of supply chain sustainability in the telecommunications industry in Indonesia.
Comparison HOR and AHP Methods in Risk Mitigation of Line Pipe Procurement
Authors: Kholid Muhammad Arwan , Harito Christian
Published: July 2024

OCTG (Oil Country Tubular Goods) is a type of pipe used for oil and gas exploration activities. To meet the demands for the fulfillment of Line Pipe material needs at PT Pertamina EP. The results of the analysis and identification of risk factors from 3 Subjet Matter Expert (SME) in Line Pipe material procurement activities. From 13 Process Activities, 16 Risk Events (Ei) and 35 Risk Agents (Aj) were obtained. In House of Risk (HOR) 1, the results of the calculation of the Aggregate Risk Potentials (ARPj) value of 35 Risk Agents (Aj), the highest Aggregate Risk Potentials (ARPj) with a value of 810. In House of Risk (HOR) 2, the results of the calculation of the Effectiveness to Difficulty ratio (ETDk) value of 4 Preventive Action (PAk), the highest Effectiveness to Difficulty ratio (ETDk) value with a value of 4860. In the Analytic Hierarchy Process (AHP), the results of the calculation of the Consistency Ratio value of 5 Criteria Weight the highest Criteria value with a percentage of 45.4% and the Consistency Ratio of 4 Alternatives the highest Alternative value with a percentage value of 44.06%. The best alternative solution in the selection of mitigation strategies for contract type selection is “TFC (Technical Framework Contract)” with the highest percentage and value. The TFC (Technical Framework Contract) contract type is in accordance with the PTK-007 Revision 5 Chapter IV Contract guidelines.
Computer Resource Utilization Analysis for Microsoft Excel and Python in Data Processing
Authors: Kelvin Kelvin , Wahab Wahidin , Wulandari Meirista
Published: July 2024

Data analysis is essential for gaining insights and making informed decisions. A crutial step in data analysis is data processing, which involves preparing and filtering raw data to ensure accuracy, consistency, and structure. While Microsoft Excel is commonly used for data processing, it is susceptible to human errors and has limitations in handling large datasets. Python provides an alternative by automating data processing through scripts executed by the interpreter. The superior software for data processing is obtained by comparing the computer resource utilization based on statistical theory approach, Wilcoxon signed-rank test. This test is appropriate because it does not require the assumption of a normal distribution, providing flexibility in comparing computer resource utilization between Microsoft Excel and Python. Microsoft Excel and Python proceed *.csv and *.xlsx files, then Task Manager recorded the data of computer resource utilization for each processing step. The Wilcoxon signed-rank test analyzes the data and evaluating two hypotheses. H0 (there is no any significant differences in computer resource utilization between Microsoft Excel and Python are calculated for each data processing) and H1 (there is significant differences in computer resource utilization between Microsoft Excel and Python are calculated for each data processing). The sum of ranks in Wilcoxon test are compared to the critical value from the Wilcoxon distribution table to determine the accepted hypothesis. Based on the Wilcoxon test results, hypothesis H1 is accepted, indicating a significant difference in computer resource utilization between Microsoft Excel and Python.
Synergy Magic Chess Optimization for 3 Evolution with Binary Integer Programming (Case Study Magic Chess v.255.1)
Authors: Pratama Jovian Dian , Wulandari Ratri Wulandari , Misshuari Imas Wihdah
Published: July 2024

Mobile Legends: Bang Bang or MLBB is a game with the Multiplayer Online Battle Arena or MOBA genre and this game genre is part of Action Real Time Strategy. This arcade mode game consists of brawl and magic chess. In magic chess mode, each player must arrange pawns in the form of heroes to create a strong synergy to defeat the opposing troops. In addition to synergy combos to manage playing strategies in Magic Chess, there are Line up heroes or hero ranks, to get synergy with 3 evolutions. The integer program can be used in designing a strategy for playing Magic Chess with the QM for Windows v5 application. Binary PBB. The objective function modeling minimizes the number of heroes used, the problem is the number of hero slots and synergies that players want, as well as the limiting value of the binary variables, namely when 0 heroes are not used or 1 when the hero is used, the solution obtained is the formulation to optimize Synergy with 3 Evolution.
Remake of Survival Horror Video Game and How It’s Implemented
Authors: Pratama Galih Dea , Shiddiqi Hafizh Ash , Hermawan Eric Savero , Novika Andien Dwi , Ardiyanto Elshad Ryan
Published: July 2024

Video game is particularly known as an interactive media designed to present entertainment among its targeted users. While being released from time to time, there comes the desire to provide the outdated games to the modern audiences, hence surfaces the trend of video game remakes, which recently presented through Resident Evil 4 that serves as the newer version to the original one released in 2005. To give better understanding on the games, there is Elemental Tetrad which emphasizes on four elements like Mechanics, Story, Aesthetics and Technology. In this research, Elemental Tetrad is utilized to analyze both versions of Resident Evil 4, diving deep into how the game elements are implemented by the games while also highlighting the advances presented in the remake version compared to the original one. There are various differences of both games, such as the existence of more new mechanics, the expanded story and characterizations, slight change in the aesthetics to accommodate the realism of the remake, with all are enabled through the usage of latest RE Engine.
Corruption Studies in Domestic Social Sciences: Political Aspect
Authors: Chirun Sergey , Gladkikh Sergey
Published: July 2024

The authors identified and analyzed the methodological and applied approaches to the phenomenon of corruption in modern Russian science. They performed a discourse analysis of research publications and dissertations on petty, political, and administrative corruption. The existing scientific interpretations of corruption, its causes, and prevention depend on the scientific school. However, scientists are unanimous in their evaluation of the negative influence of corruption factors on political, social, and economic domestic and global processes, which demonstrates the relevance of corruption studies. Corruption causes threats, risks, and challenges to society, which might result in an uncontrolled transformation of socio-political systems, hence the need for further interdisciplinary research.
Transformation of Russian Family: History and Modern Trends
Authors: Protasova Tatiana
Published: July 2024

In modern Russia, the family institution is a matter of national security. This research featured the key transformations of the modern Russian family. The article presents the transformation stages in the context of the actual social relations, identifies the factors of these changes, and establishes the main trends that characterize the current state of the Russian family. Family models have become more diverse, as well as the strategies of couple relationship and parenthood. The traditional family functions are undergoing some transformations, e.g., new formats appear while others fade into the past. The modern family is characterized by individualism and rationalization instead of standards. Late parenthood requires more available reproductive technologies. These new trends are to be observed all over the country and in all age groups. Young metropolitan dwellers manifest rationalization and freedom of choice: they make marriage and divorce decisions quite easily, see marriage as optional, and are prone to late marriage and parenthood. The concept and implementation of state family policy in modern Russia need to take into account the abovementioned trends, as well as the actual attitude of the population to family relations and parenthood.
Mental Concept of Professional Identification in Youth: Part I
Authors: P'yankova Lyudmila
Published: July 2024

The development of the youth professional orientation mental concept is considered in the context of solving the socio-economic and legal relations problem under a shortage of labor resources and meta-subject competencies, which reflects the cognitive, value and worldview, as well as behavioral bifurcation of human civilization. Mentality is a complex existential, anthropological and phenomenological concept, a unique result of purposeful action of the social environment internalization and a prerequisite for its transformation. It forms under an axiological split in the society and is determined by intrapersonal, socio-economic, cultural, and historical factors. The mental concept construction is based on the idea of smoothing out the value and worldview contradictions, possibly transforming the institutions that seek to change the norms in the public consciousness in the direction of negotiability, increasing the level of trust, which reduces enterprises activities’ transaction costs. The methodological basis of the implemented concept is made up of the anthropological and convergent approaches’ provisions.
Reinterpreting Buddhist Iconography: A Study of Craft Meanings and Uses in Everyday Living Architectures through ‘Iconic Interactionism’
Authors: Deepika  ,   Associate Professor, Department of Media Studies, Gurugram University.
Published: July 2024

This study takes a unique approach, focusing on the iconography and psychological use of Buddhist handicrafts in everyday life. Through qualitative methods, we delve into the interpretation and meanings given to a series of Buddhist handicrafts, such as a Buddha statue, prayer wheel, flag, and other symbolic craft. Our aim is to examine how the assigned symbolic meanings of craft correlate with the interpreted meaning given to craft by respondents as an activity in relation to their well-being. The paper is grounded in the theoretical implications of iconography and reception analysis. The outcomes reveal the therapeutic nature of craft as a meaningful symbol of living architecture for those involved in the interpretation and consumption of handicrafts. The significance and symbolic meaning of handicrafts are defined as the meaning and value, the feelings and experiences of use, and the social and cultural dimensions associated with craft as a stress-relieving, mind-calming activity and in maintaining well-being. Finally, the study’s outcome leads to the development of the theoretical contribution of ‘Iconic Interactionism’ detailed in the paper’s last section.
Saline intrusion assessment using the GALDIT index on the northern coast of Quintana Roo, Yucatan Peninsula, Mexico
Authors: Trejo-Albuerne Adriana , Canul-Macario Cesar
Published: July 2024

Rapid urbanization and population growth driven by global tourism in cities such as Cancun, Playa del Carmen, Tulum, and Puerto Morelos, in Quintana Roo, are major stressors in the Yucatan Peninsula aquifer. As this aquifer is the main water source for all anthropic and socio-economic activities in the region, management conservation actions must be carefully established. Being a coastal aquifer, saline intrusion must be addressed and analyzed. However, there are scarce previous works in this regard for the region, making it difficult to incorporate these elements into territorial planning and adaptive groundwater management. This work uses free-access data to characterize the saline intrusion of aquifers on the Quintana Roo north coast through the processing, adaptation, and cartographic representation of the GALDIT index. This approach identified areas of the aquifer that could show saline intrusion, and later, these results were contrasted with the water supply zones of the main coastal cities of northern Quintana Roo. These results are a novelty approach for Quintana Roo and are hugely relevant at the regional level. In addition, they can be used as input to promote water management strategies and territorial planning.
Ensemble hydrological predictions at an intraseasonal scale through a statistical–dynamical downscaling approach over southwestern Amazonia
Authors: Gomes Weslley Brito , Satyamurty Prakki , Correia Francis Wagner Silva , Chou Sin Chan , Fleischmann Ayan Santos , Papa Fabrice , Vergasta Leonardo Alves , Lyra André de Arruda
Published: July 2024

We developed and analyzed the performance of an ensemble forecasting system for the Madeira River basin, the largest sub-basin of the Amazon, with forecasts up to 30 days under different hydrometeorological conditions. We used outputs from the regional Eta model of precipitation and global climatological data as inputs to a large-scale hydrological model. Bias correction of precipitation through quantile mapping significantly improved the results, achieving a hit rate >70%. The system demonstrated the ability to discriminate between high, medium, and low flow conditions. Forecast performance is better for larger catchment areas. This system is expected to increase decision-making efficiency for flood and drought situations in the largest Amazon tributary.
Optimizing the number, locations, and chlorine dosages of booster chlorination stations in water distribution networks
Authors: Sime Yomif Dereje , Kansal Mitthan Lal
Published: July 2024

Safe and reliable drinking water is essential for sustaining life. Chlorination is widely used for disinfection in water distribution networks (WDNs). A higher dose of chlorine is required in an overhead service reservoir to maintain minimum residual chlorine at the farthest end in WDNs. However, delivering high dosages of chlorine from storage tanks can pose public health issues, especially for the residents living near overhead service reservoirs due to the formation of trihalomethanes, haloacetic acids, and chlorophenols. In addition, a higher dosage will lead to increased chlorine consumption and will accelerate pipe corrosion. Booster chlorination (BC) stations with smaller dosages are a solution to this problem. However, identifying the optimal number, locations, and dosage of each BC station in a cost-effective manner is challenging. This study proposes a methodology for determining the optimal number, locations, and chlorine dosages of BC stations in WDNs using a mixed integer linear programming problem. The methodology is illustrated through a simplified WDN in Holeta town, Ethiopia. The results indicate that if one adds two BC stations beyond the three dosage stations at the source, it will lead to a 49% reduction in chlorine use and a 27% decrease in the life cycle cost.
Single-atom catalysts activate persulfate to degrade emerging organic contaminants in aqueous environments
Authors: Qin Zixun , Zhang Zhonglei , Li Ji , Liu Jin , Wang Jinsheng , Chen Xiaoguo , Wang Yangyang , Wang Lei
Published: July 2024

Single-atom catalysts (SACs) exhibit outstanding catalytic activity due to their highly dispersed metal centers. Activating persulfates (PS) with SACs can generate various reactive oxygen species (ROS) to efficiently degrade emerging organic contaminants (EOCs) in aqueous environments, offering unique advantages such as high reaction rates and excellent stability. This technique has been extensively researched and holds enormous potential applications. In this paper, we comprehensively elaborated on the synthesis methods of SACs and their limitations, and factors influencing the catalytic performance of SACs, including metal center characteristics, coordination environment, and types of substrates. We also analyzed practical considerations for application. Subsequently, we discussed the mechanism of SACs activating PS for EOCs degradation, encompassing adsorption processes, radical pathways, and non-radical pathways. Finally, we provide prospects and outline our vision for future research, aiming to guide advancements in applying this technique.
Synthetic Development in Inulin Modification and its Applications
Authors: Singh Mahendra , Rani Himanshu , Chopra Harish Kumar
Published: July 2024

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Inulin is a naturally occurring polydisperse and flexible polysaccharide. It is a
non-toxic, biocompatible, water-soluble, biodegradable, and affordable polymer. Furthermore,
because of its unique properties, inulin has piqued the interest of many researchers.
Studies have revealed that inulin demonstrates a broad range of biological activities such as
antioxidant, antifungal, antibacterial, anticancer, antidiabetic, and immunological modulating
properties in the pharmaceutical industry. Inulin has been demonstrated to function as a
sweetener, fat replacer, water-holding agent, thickener, texture modifier, and browning
agent in dairy and bakery food items. Inulin has produced EMF, a biofuel that is one of the
most desirable gasoline substitutes. Today, inulin is widely used in the chemical, food, and
pharmaceutical industries. Chemical modification of inulin is an important methodology for
expanding its applications in a variety of fields. This article discusses the numerous synthesis
methods used to modify the inulin structure, including conventional and non-conventional methods such as
microwave and ultrasonication, as well as the diverse applications of inulin and its derivatives in several industries.
This review article seeks to explore the current state of research on synthetic modifications of inulin and
its wide array of applications.
Diabetic Heart Disease: An Intricate Interplay of a Widespread Metabolic Disorder with the Cardiovascular System
Authors: Shriya A.S. Kamakshi , Pawar Vaishnavi B. , Paul Acsah Annie
Published: July 2024

Diabetes is a chronic medical condition that causes high glycaemic levels, leading to
damage to vital organs over time. It is a common disease worldwide, affecting around 422 million
individuals living in middle- and low-income countries, which make up most of the population.
Unfortunately, diabetes results in 1.5 million deaths annually. Diabetic patients are at a
higher risk for developing cardiovascular conditions. Diabetic heart disease constitutes multiple
genres, including diabetic cardiomyopathy, coronary artery disease, and heart failure. Hypoglycaemic
agents aim to prevent these metabolic issues however some of these are cardiotoxic in
nature. In contrast, other hypoglycaemic agents work beyond controlling glycaemic levels with
their cardioprotective properties. Given that there is an alarming increase in diabetic heart disease
cases universally, we have attempted to review the existing data on the topic and the effects
of hypoglycaemic drugs on heart diseases.
Apocynaceae as a Potential Source for Acetylcholinesterase Inhibition in Symptomatic Regulation and Management of Alzheimer's Disease
Authors: Kumari Priyanka , Sarwa Naveen , Meena Deepak , Eesha Ajaya , Chaudhary Navneet Singh
Published: July 2024

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Memory loss or dementia is the key symptom of Alzheimer's disease (AD). In AD, significant
interference in a progressive manner is observed in memory, behaviour, and cognitive abilities
that affect the daily life of a person. At present, more than 50 million people are affected
worldwide with Alzheimer's disease. Urgent attention is needed for the symptomatic regulation and
management of this disease. The significant pharmacotherapy research in the last two decades gave
only four drug compounds galanthamine, donepezil, rivastigmine, and memantine that inhibit the
enzyme acetylcholinesterase (AChE) to elevate the availability of acetylcholine in the brain for
symptomatic relief in AD patients. Plant-based AChE inhibitors from many plant families, mainly
including Rutaceae, Papaveraceae, Apocynaceae, Rubiaceae, Amaryllidaceae, Liliaceae, Lycopodiaceae,
Fabaceae, Lamiaceae, etc., have been characterized for the management of AD progression.
AD progression is described by cholinergic, amyloid, Tau protein, oxidative stress, and neuroinflammatory
hypothesis. To date, there is no comprehensive review in the literature that combined all
plants of the Apocynaceae family showing anti-AChE activity. Therefore, the current review aims to
present significant literature, especially on plant-derived compounds from the Apocynaceae family
that inhibit AChE. The review compiled all plants showing potent anti-acetylcholinesterase activity.
The anti-AChE activity of more than 30 plants is described, which may be potential targets to find
new drug molecules by attracting the attention of researchers toward the Apocynaceae family. More
than 8 species of genus Tabernaemontana of Apocynaceae have been investigated for indole alkaloids,
demonstrating AChE inhibitory activity. The majority of anti-AChE compounds belong to the
class of alkaloids.