bluuebunny/crossref_metadata_2025 huggingface dataset:
NGHIÊN CỨU TỔNG QUAN VỀ MỐI LIÊN QUAN GIỮA GEN VÀ CÁC BỆNH CHUYỂN HÓA TRÊN CƠ SỞ XÉT NGHIỆM GEN CircleDNA
Authors: Hồng Sơn Trương , Xuân Ninh Nguyễn , Liên Hương Lưu , Minh Khánh Lê
Published: February 2022

Gen và các bệnh chuyển hóa là một nhánh của xét nghiệm gen, nhằm xác định vai trò của các biến thể gen đặc hiệu với các vấn đề liên quan đến chuyển hóa ví dụ như khả năng điều hòa đáp ứng với các thành phần của chế độ ăn, các kết quả của tương tác gen với chế độ ăn đến tình trạng sức khỏe và đặc biệt là khả năng mắc các bệnh liên quan đến chuyển hóa. Các nghiên cứu về Gen và các bệnh chuyển hóa trong lâm sàng đã cho thấy: (1) Các gen được chứng minh là có liên quan khá mạnh đến bệnh tiểu đường type 2 là TCF7L2, tiểu đường typ 1 là SLC30A8, (2) Các gen đã được chứng minh là có liên quan đến tất cả các chỉ số đánh giá rối loạn lipid máu, bao gồm cholesterol toàn phần, LDL, HDL và triglyceride là PCSK9 và LDLR, (3) Một số đa hình của gen FTO có thể làm tăng nguy cơ thừa cân béo phì trên nhiều đối tượng như người trưởng thành, trẻ em…Gen BDNF có ảnh hưởng đến quá trình điều hoà cân bằng năng lượng, cũng như các cảm giác thèm ăn và các rối loạn về thần kinh liên quan, (4) Gen đã được chứng minh có liên quan đến các dạng ung thư thường gặp bao gồm gen MSH2 với ung thư đại trực tràng, BRCA1, BRCA2 với ung thư vú.
MỘT SỐ YẾU TỐ LIÊN QUAN ĐẾN CHẤP NHẬN TIÊM VẮC XIN PHÒNG COVID-19 DO VIỆT NAM SẢN XUẤT
Authors: Thị Hà Nguyễn , Văn Lăng Ngô , Hùng Dũng Đặng , Thị Yến Thư Phạm
Published: February 2022

Nghiên cứu mô tả cắt ngang trên 1020 người ở Việt Nam (VN) có độ tuổi từ 18 trở lên từ ngày 28/8 đến 7/9/2021. Mục tiêu nghiên cứu nhằm xác định tỷ lệ và một số yếu tố liên quan đến chấp nhận tiêm vắc xin phòng COVID-19 do VN. Kết quả: Có 86,37% đối tượng nghiên cứu (ĐTNC) sẵn sàng tiêm vắc xin phòng COVID-19 do VN sản xuất. Các yếu tố liên quan đến tỉ lệ chấp nhận tiêm vắc xin phòng COVID-19 do VN sản xuất là nhóm tuổi 30-39 chấp nhận thấp hơn so với nhóm 18-29 là 0,62 lần (p<0,05), nông thôn chấp nhận tiêm cao hơn thành phố 1,92 lần (p<0,05), giới tính nữ chấp nhân tiêm gấp 2,21 lần so với nam giới (p<0,0010), đối tượng lao động tự do chấp nhận tiêm cao hơn công chức/viên chức là 1,79 lần (p<0,05), tình trạng mắc bệnh mãn tính chấp nhận tiêm thấp hơn nhóm không mắc bệnh là 0,39 lần (p<0,001); người có tiền sử dị ứng hoặc không biết mình có nguy cơ dị ứng hay không chấp nhận tiêm thấp hơn đối tượng không có tiền sử dị ứng 0,37 lần (p<0,001) và 0,49 lần (p<0,05). Kết luận: kết quả nghiên cứu cho thấy tỷ lệ ĐTNC chấp nhận tiêm vắc xin do VN sản xuất là khá cao. Các yếu tố liên quan đến tỷ lệ chấp nhận tiêm vắc xin có ý nghĩa là vùng miền, giới tính, tình trạng mắc bệnh mãn tính và tiền sử dị ứng.
NGHIÊN CỨU QUY TRÌNH BÀO CHẾ VÀ XÂY DỰNG TIÊU CHUẨN CƠ SỞ CHO CỒN XOA BÓP AN BÌNH TẠI TRƯỜNG ĐẠI HỌC Y DƯỢC THÁI BÌNH
Authors: Việt Khánh Nguyễn
Published: February 2022

Mục tiêu nghiên cứu: Xây dựng được quy trình bào chế Cồn xoa bóp An Bình, Xây dựng được tiêu  chuẩn cơ sở cho sản phẩm. Phương pháp nghiên cứu: Ngâm lạnh, ngâm nhỏ giọt và hòa tan. Địa điểm nghiên cứu: Nghiên cứu được tiến hành tại Khoa Dược - Trường Đại học Y Dược Thái Bình. Đối tượng nghiên cứu: là các kỹ thuật sản xuất Cồn xoa bóp, các chỉ tiêu kỹ thuật khi xây dựng tiêu chuẩn chất lượng của cồn xoa bóp. Kết quả nghiên cứu thu được: quy trình và các bước tiến hành bào chế cồn xoa bóp An Bình, xây dựng được tiêu chuẩn cơ sở cho cồn xoa bóp An Bình.
An investigation into the clinical practicum experience of als paramedic students and their preparedness for professional practice
Authors:   , Moodley Kubendhren
Published: February 2022

Clinical practicum remains an integral part of training and a vital component of the emergency medical care curriculum that takes place in a realistic and complex emergency care environment. Clinical practicum should provide students with the opportunity to combine cognitive, psychomotor and affective skills to develop competencies to prepare the qualifying practitioner for demands of pre-hospital emergency care in the real world. The aim of this study was to explore the multidimensional aspects of the clinical practicum experience of ALS paramedic students in the Western Cape through the lens of a qualitative research design. The study involved exploring the experience of paramedic students in the clinical practice placement. In addition, the views of paramedic graduates were also explored, to ascertain whether the placement experience adequately prepared them for practice. An analysis of the clinical practice documents utilised in the training of ALS paramedic students was conducted with particular reference to identify correlations with relevant literature. In addition, it was necessary to identify how clinical practice manifested itself, not only in what students and graduates express but also how it was coordinated and conveyed in a professional work related context, against the backdrop of the work integrated learning framework. Using a case study design, focus group interviews were conducted with final year EMC students from CPUT and CCA students from the Western Cape CEC. This was followed with one on one interview with paramedic graduates. Further to this, clinical practice documents were analysed to triangulate the data. This study revealed that the clinical practice learning objectives for paramedic students were not adequately achieved and paramedic graduates felt ill prepared for independent practice. These discrepancies were attributed to the complex issues both in theory and practice. The study provided a number of recommendations for improving the clinical training experience, such that paramedic graduates who enter the complex and challenging world of EMC are better prepared.
Controle de Sistemas por Computador: Projeto e identificação
Authors: Meza Magno Enrique Mendoza
Published: February 2022

Este livro apresenta conceitos sobre sistemas de controle discretos no tempo para o projeto de controladores, observadores e identificação de sistemas lineares. A transformada Z é apresentada de maneira resumida por ser a ferramenta essencial para análise dos sistemas de controle em tempo discreto. Os métodos de projeto de controladores abordados são: a resposta em frequência, a realimentação de estados com o controle ótimo, o controle preditivo por modelo, entre outros. Mostram-se exemplos práticos de implementação de alguns controladores e observadores em um microcontrolador Arduino para um circuito RLC série.
Como se Faz: 99 soluções de instalações hidráulicas e sanitárias - Um guia prático para engenheiros e arquitetos
Authors: Carvalho Júnior Roberto de
Published: February 2022

Toda instalação está fadada ao desgaste natural decorrente da ação do tempo. As tubulações, as peças e os dispositivos utilizados nas instalações têm uma vida útil que pode ser maior ou menor, dependendo do tipo de material e das condições de utilização. Pensando nisso, este guia prático foi desenvolvido com a finalidade de apresentar a engenheiros, arquitetos, construtores, instaladores e demais profissionais envolvidos na construção civil 99 soluções de instalações hidráulicas e sanitárias, criteriosamente selecionadas em grau de importância, sob a ótica do autor, referentes a projeto, execução, desempenho e manutenção (preventiva, corretiva e de urgência) de instalações hidráulicas e sanitárias, além de evidenciar a importância das normas brasileiras que regem cada assunto tratado.
Estabilidade do Equilíbrio das Estruturas
Authors: Brasil Reyolando Manoel Lopes Rebello da Fonseca
Published: February 2022

Este livro estuda a estabilidade do equilíbrio de estruturas civis, mecânicas, navais, e aeroespaciais do tipo barras e placas. Abordam-se a teoria e os processos numéricos de solução, em especial o Métodos dos Elementos Finitos e sua implementação computacional.Com a modernização das técnicas de análise e a disponibilidade de materiais cada vez mais resistentes e métodos construtivos mais apurados, é a realidade atual da Engenharia de Estruturas que as peças se tornem cada vez mais esbeltas e, portanto, mais sujeitas a possíveis problemas de instabilidade. O fenômeno historicamente denominado de flambagem é aqui estendido para contemplar a inevitável existência de imperfeições nas estruturas reais.Este livro é um texto básico para graduação ou pós-graduação, mas também para o engenheiro estrutural praticante.
Economia Circular, Sistemas Locais de Produção e Ecoparques Industriais: Princípios, modelos e casos (aplicações)
Authors: Amato Neto João , Barros Marcos Cesar Lopes , Campo-Silva Willerson Lucas
Published: February 2022

O livro Economia circular, sistemas locais de produção e ecoparques industriais: princípios, modelos e casos (aplicações) foi realizado por um Centro de Excelência sobre “Redes de cooperação e gestão do conhecimento”, da Universidade de São Paulo (USP), e liderado pelo Prof. João Amato, com ampla e relevante experiência na Engenharia de Produção. A obra traz uma grande contribuição para a área, com casos práticos e detalhados de ecoparques industriais, embasados por uma conceituação teórica de temas complementares e integrados. Esta obra, que integra Economia Circular, Sistemas Locais de Produção e Ecoparques Industriais, nos clama para expandirmos nossa visão de negócio e engenharia para o sistêmico, para a multi e transdisciplinariedade, para a cooperação, para a geração de valor, para o valor compartilhado, para o impacto positivo, para o longo prazo, para a integração, para maior diversidade, resiliência e efetividade.
Da Teoria à Prática no Cálculo do BDI: Benefício e despesas indiretas
Authors: Tisaka Maçahico
Published: February 2022

Este livro tem como principal objetivo contribuir para o debate e o esclarecimento de algumas controvérsias existentes entre os cultores da engenharia de custos no entendimento técnico e na quantificação dos parâmetros que compõem a taxa do BDI (Benefício e Despesas Indiretas). Além disso, visa orientar os profissionais que atuam nas áreas de engenharia que participam de quaisquer etapas de obras ou serviços públicos ou privados, seja por serviço prestado, cargo ou função, com suas responsabilidades enquanto profissional em quem a sociedade confia, assim como por todo e qualquer cidadão que tem o dever cívico de zelar e contribuir com a sociedade da qual faz parte. Também espera-se que seja de valia para fins de consulta e reflexão para profissionais, engenheiros do segmento da construção, advogados, servidores públicos, consultores, projetistas, gerenciadores de obras, orçamentistas, enfim, todos os profissionais que possam estar direta ou indiretamente envolvidos na contratação de obras públicas ou privadas, controle e gestão de recursos, bem como, no exercício de funções públicas ou privadas.
O Psiquiatra em Conflito: Fatos, valores e virtudes nas internações involuntárias
Authors: Castellana Gustavo Bonini
Published: February 2022

Tomar decisões é fazer escolhas, negar possibilidades em prol de uma delas. Escolher é sempre aposta: implica incertezas, pode trazer arrependimento. Imagine-se, então, a responsabilidade envolvida em decidir quando se está em posição de autoridade e a decisão a ser tomada envolve a felicidade do outro. É esse o desafio explorado nesta instigante obra sobre a decisão da internação psiquiátrica. Alinhando-se à tradição da filosofia prática, este livro não nos ensinará o que decidir, mas certamente nos ajudará a compreender as virtudes que podem nos nortear e os dilemas a se enfrentar nesse tipo de decisão. José Ricardo de Carvalho Mesquita Ayres Professor titular do Departamento de Medicina Preventiva da FMUSP
Álgebra Linear
Authors: Zahn Maurício
Published: February 2022

Neste livro, o leitor irá encontrar o conteúdo de um primeiro curso de Álgebra Linear, abrangendo todos os tópicos abordados nessa disciplina, desde matrizes a espaços com produto interno. O autor procurou apresentar a teoria por inteiro, ou seja, o conteúdo foi escrito com todas as explicações necessárias para deixar o texto autossuficiente, recorrendo à linguagem da geometria analítica (um pré-requisito para a álgebra linear com o qual os alunos já estão familiarizados), mantendo todas as proposições demonstradas com riqueza de detalhes. Além disso, há uma ampla coleção de exercícios resolvidos e exercícios propostos, proporcionando uma harmonia entre teoria e exercícios. Também foram incluídos dois apêndices ao final da obra, onde apresentamos a resolução de vários exercícios, sendo muitos deles de seleções de mestrado em Matemática de algumas universidades do Brasil, e uma explicação sobre o princípio da indução matemática.
DRUGS AS INDUCERS OF STEVENS-JOHNSON SYNDROME - TOXIC EPIDERMAL NECROLYSIS IN CHILDREN
Authors: Dyubkova T. P. , Zhernosek V. F.
Published: February 2022

The review presents causes and clinical features of Stevens-Johnson syndrome, toxic epidermal necrolysis (SJS/TEN), in children and analyzes the role of drugs as inducers of the illness. The high risk of SJS/TEN in children is associated with co-trimoxazol (sulfamethoxazol + trimethoprim), other anti-infective sulfonamides, anticonvulsants (phenobarbital, carbamazepin, lamotrigine), non-steroidal anti-inflammatory drugs of the oxicam-type. The highest risk of SJS/TEN development occurs during the first eight weeks of treatment with a subsequent sharp decrease in the incidence rate. Certain genetic factors contribute to SJS/TEN development.
THE COMPARISON OF THE CLINICAL PICTURE OF RADICULOPATHY WITH THE LEVEL OF DEVELOPMENT OF HERNIA IN THE LUMBAR INTERVERTEBRAL DISK M. V. Olizarovich
Authors: Olizarovich M. V.
Published: February 2022

The aim of this study was to analyze the neurological manifestations in lumbar osteochondrosis considering the CT (MRI) imaging of the lumbosacral spine. Material and methods. The study included a survey of patients and evaluation of clinical data with respect to the results of CT and MRI neuroimaging of the lumbar spine. We conducted personal interviews, studied medical records and protocols of tomographic studies of 60 patients treated in the neurosurgical department of the Gomel Regional Hospital within 2010-2011. Results . Most patients (42-70.0 %) observed expressed or pronounced symptoms of tension. Lasegue symptom was absent in few cases - in 3 (5.0 %) people. Twelve (20,0 %) patients from the group of patients with neurological manifestations of lumbar osteochondrosis strength detected motor deficit. The paresis of the muscles of the big toe prevailed in 6 (10.0 %) people. In the vast majority of cases (48 people - 80.0 %), the decrease in muscle strength of legs was not found. The lesion of foot flexors prevailed over that of extensors (p < 0.05). Conclusion . Most often the pronounced Lasegue symptom was found in prolapse of herniated disks LV-SI (23.3 %). Absence of tension symptoms was rare (5.0%). The expressed prevalence of clinical symptomatology depending on the level of the intervertebral disc herniation was revealed most frequently in the paresis of foot flexors (75.0 % of all the cases in of hernia at LIV-LV level) (p < 0.05). When analyzing the cases of the paresis of the extensor muscles of the foot and big toe, we did not find any prevalent kind of the herniated disc.
PATHOMORPHOLOGICAL REACTIONS OF VASCULAR COMPONENT OF COMMUNICATION SYSTEMS IN ACUTE DISORDERS OF CEREBRAL CIRCULATION
Authors: Nimer S. N.
Published: February 2022

Annually, about 6 million people in the world and more than 450 thousand in Russia suffer from cerebral stroke, i.e. every 1.5 minutes a Russian develops this disease. In large megalopolises of Russia, the number of acute stroke is from 100 to 120 per day. Stroke is currently one of the main causes of disability in population. 70-80 % survivors become disabled after stroke, and approximately 20-30 % of them need constant outside care. Among all types of stroke, ischemic brain lesions are predominant. Ischemic strokes account for 70-85 % of the cases, cerebral haemorrhage - 20-25 % of the cases, nontraumatic subarachnoid hemorrhage - 5 % of the cases. Stroke is now becoming a major social and health issue of neurology. In general, stroke is the second leading cause of death (after acute heart disease), and mortality in men is higher than in women.
THE STUDY OF PRO- AND ANTI-INFLAMMATORY CYTOKINES IN CHILDREN WITH UROPATHY OF THE UPPER URINARY TRACTS
Authors: Drannik G. N. , Peterburgskiy V. F. , Driyanskaya V. E. , Kalinina N. A. , Bagdasarova I. V. , Gayseniuk F. Z. , Lavrenchuk O. V. , Poroshina T. V. , Sevastyanova N. A.
Published: February 2022

The purpose of the work is to study the role and significance of the research for pro- (TNF-α, IL-23, MCP-1) and anti-inflammatory (TGF-β) blood cytokines in blood and urine in children with uropathy of the upper urinary tracts (UUUT). Material and methods . 52 children with UUUT (1 group) and also 43 children free of UUUT with the infected urinary system (2 group) were examined. The immuno-enzymic method ELISA and the corresponding test-systems were used to study the levels of cytokines in blood and urine. Results. The analysis showed a significant increase in the levels of all the studied pro- (TNF-α, MCP-1, IL-23) and anti-inflammatory (TGF-β 1) cytokines in the blood of the patients in groups 1 and 2. The levels of TNF-α and TGF-β in urine are considered as diagnostic markers of inflammation and fibrosis, including the state after reconstructive surgery, and that of MCP-1 in blood - as acute aggravation of chronic pyelonephritis. Conclusion. The TNF-α and TGF-β levels in blood of the children with congenital uropathy can be additional diagnostic and prognostic markers and also in the dynamics of the treatment with nephroprotection.
ANTIBIOTIC SENSITIVITY TO STAPHYLOCOCCUS AUREUS IN CHILDREN OF GRODNO REGION SUFFERING FROM CHRONIC TONSILLITIS
Authors: Bedin P. G. , Lyalikov S. A. , Nekrashevich T. V. , Soltan N. G. , Novomlinova L. V. , Kartashevich I. P.
Published: February 2022

Objective: to assess the sensitivity of Staphylococcus aureus to main antibacterial preparations in children of Grodno region. Material and methods. The results of the study of all tonsil smears of children suffering from chronic tonsillitis and admitted to the Grodno Regional Center for Hygiene, Epidemiology and Public Health in 2010, were analyzed. The median age of the children was 8, and the interquartile range was 4-13. Inoculation, cultivation, identification and determination of antibiotic sensitivity was conducted in accordance with the existing regulations. Results. 1000 cultures belonging to 14 families, genera and species of microorganisms were received. 578 people identified a monoculture of bacteria, 200 revealed two cultures, and in 7 children - three cultures. In one case the growth of both bacteria and fungi was absent. 289 patients detected Staphylococcus aureus. In 66.7 % of the cases it was combined with other bacteria, and 16.9 % - with Candida fungi. Conclusion. At present, the children of Grodno region detect Staphylococcus aureus reliably more often in the autumn and in children over five. The majority of the identified cultures are resistant to β-lactam antibiotics and clavulanic acid. Metitillinresistent strains are prevalent. Sensitivity to certain antibacterial drugs has seasonal fluctuations and depends on the kind of coinfection.
THE COURSE OF CEREBRAL VASCULAR INSUFFICIENCY IN PATHOLOGIC TORTUOSITY OF CAROTID ARTERIES, ITS ROLE IN INDICATIONS FOR SURGICAL TREATMENT
Authors: Kaplan M. L. , Bontsevich D. N.
Published: February 2022

The article describes the effect of pathologic tortuosity of carotid arteries on cerebral circulation, variants of the course of vascular cerebral insufficiency and clinical manifestations, their role in indication for surgical treatment. The pathologic tortuosity of carotid arteries is revealed by the clinical picture of vascular cerebral insufficiency in carotid and/or vertebrobasilar basins. The work assesses the role of spiral computed tomography with contrasting and magnetic resonance imaging in the verification of signs of episodes of focal neurologic deficiency in patients with the tortuosity of carotid arteries and the potential for application of transcranial Doppler for evaluation of cerebral blood flow disorders in different variants of cerebral vascular insufficiency. The article covers the problems of analysis of the received data for indication for surgical treatment for the tortuous internal carotid artery and presents the long-term results of the surgical treatment of the patients with tortuosity of carotid artery (dynamics of neurological symptoms and the absence of cerebral infarction on the area of the surgery).
THE DYNAMICS OF ANTIOXIDANT ACTIVITY OF BLOOD SERUM AND INTESTINAL CONTENT IN EXPERIMENTAL ANIMALS IN SIMULATED ACUTE INTESTINAL OBSTRUCTION
Authors: Ugolnik D. V. , Kozlovskaya T. V.
Published: February 2022

The article studies the changes of antioxidant activity of blood serum and intestinal content in experimental animals 12, 24, 36 hours after simulated acute intestinal obstruction (AIO). The experiment included 77 adult male inbred albino rats, which were included into trial (n = 27) and control (n = 50) groups. AIO in the rats is accompanied by inhibition of antioxidant properties of the serum and intestinal content, the development of endotoxemia already within the first day of AIO. The animals with AIO have unidirectional changes of the antioxidant status in the serum and intestinal content, but later occurring with greater intensity. These data show the need for application of antihypoxic oriented drugs in the comprehensive therapy program of AIO treatment.
DOZE-FORMING FOODSTUFFS IN THE DIET OF THE RURAL POPULATION OF GOMEL REGION
Authors: Degtyareva E. I. , Saraseko E. G.
Published: February 2022

The article presents the results of the research aimed at determination of dose-forming foodstuffs in daily diet of the population of North-East Gomel region. The internal irradiation dose of the population of Chechersk, Vetka, Dobrush districts within 2009-2012 was formed basically at the expense of milk. The article presents the results of the radiometric research of foodstuffs produced in private and collective farms in the above listed districts.
OUR FIRST APPLICATION OF RECOMBINAN TISSUE PLASMINOGEN ACTIVATOR IN TREATMENT FOR A NEWBORN CHILD WITH CATHETER-ASSOCIATED TROMB OF THE RIGHT ATRIUM
Authors: Karamyshev A. M.
Published: February 2022

The article presents a case of a baby born at the Gomel Regional Clinical Hospital in 2013. The baby, born at the Gomel Regional Maternity Hospital had surgery according to life indications, severe blood loss, hemorragic shock, disseminated intravascular clotting and syndrome of multiorgan disfunction. The patient later developed a large catheter-associated trombus of the right atrium with pulmonary embolism. [1, 2, 3, 5]. We did not have any clinical experience on trombolytic therapy in newborns after hemorragic shock. We could not find any standard recommendations, descriptions of similar cases in information resources. The newborn received a recombinant tissue plasminogen activator and later we removed the central venous catheter with the remains of the trombus. The trombolysis with the recombinant tissue plasminogen activator was successful and without any complications. The baby survived and was discharged from the hospital.
FUNCTIONAL DIGESTIVE DISORDERS IN INFANTS
Authors: Kozlovsky A. A.
Published: February 2022

The article presents generalized information about functional digestive disorders in infants. It reflects epidemiology, causes, clinical manifestations and diagnostic criteria for regurgitation, colics and functional constipation in infants. Special attention is given to medicamental and diet correction of the mentioned pathology in children during their first year of life. The practical application of the proposed recommendations for breeding of children with functional digestive disorders during their first year of life will make it possible to arrest clinical manifestations of the illness not resorting to medicamental treatment.
MARKERS OF CERTAIN OPPORTUNISTIC INFECTIONS IN HIV-POSITIVE CHILDREN
Authors: Anischenko E. V. , Krasavtsev E. L. , Karmazin V. V. , Kaznacheyeva E. P.
Published: February 2022

The paper presents data on the prevalence of markers of certain opportunistic infections in both HIV-positive children infected via vertical transmission and registered at the HIV/AIDS outpatient consultative ward of the Gomel Regional Infectious Clinical Hospital and in HIV-negative children. The HIV-positive children (43 %) in comparison to the HIV-negative children (26 %, p = 0.008) detected EBV DNA significantly more often. However, the group of the HIV-negative children revealed CMV Ig G more often (50 % vs. 12 % in HIV-positive, p = 0,02). HSV1/2 DNA in the study groups of the children was not detected. The children did not detect Ig M to toxoplasmosis atibodies). CMV, HSV 1/2.
THE ORGANIZATIONAL BASICS OF MEDICAL AND SANITARY SUPPORT OF REACTION PARTICIPANTS IN A RADIATION ACCIDENT
Authors: Bortnovsky V. N. , Buzdalikin K. N.
Published: February 2022

Construction of a new radiation hazardous project in the Republic of Belarus and extension of the maintenance term of existing nuclear reactors, building of storages of waste fuel beside its borders, increasing risks for terrorist threats raise the demands for readiness for radiation accidents, including organization and realization of medical and sanitary support activities for participants of accident reaction. The article summarizes practical proposals to create a crisis center for medical support of accident reaction participants in emergency situations with a radiation factor.
THE SANITARY AND CHEMICAL ASSESSMENT OF THE CONTENTS OF TOXIC ANIONS IN NATURAL WATERS OF GOMEL REGION
Authors: Zykova E. L. , Dovnar A. K. , Filippova V. A. , Lysenkova A. V.
Published: February 2022

The article deals with the data on the quantitative content of toxic anions in the natural waters of reservoirs and bore holes in Gomel region. The obtained results show the satisfactory quality of the natural waters, applied for the supply of drinking water.
ACUTE APPENDICITIS DURING LATE PREGNANCY
Authors: Krot I. F. , Eynysh E. A. , Prizentsov A. A.
Published: February 2022

Acute appendicitis is the most common acute surgical abdominal disease in pregnant women, and in most cases has а non-typical and complicated course. The article presents a brief literature review and describes two clinical cases of the complicated forms of acute appendicitis in the III trimester of pregnancy. In the former case, there was appendicular abscess caused by untimely diagnosis, the surgery was performed on the seventeenth day from the onset of the illness at a term of 35 weeks. In the latter case, a woman at a term of 35-36 weeks was performed appendectomy and two days after the surgery she gave birth vaginally and then on the ninth day developed adhesive intestinal obstruction. Both the women had a preterm vaginal delivery on days 2 and 9 of the postoperative period.
ОЖИРЕНИЕ: СОВРЕМЕННЫЙ ВЗГЛЯД НА ПРОБЛЕМУ (лекция, часть II)
Authors: Turchenko N. M. , Turchenko S. Yu.
Published: February 2022

Obesity is a chronic multifactorial heterogeneous disease characterized by excessive accumulation of body fat (in men - at least 20 % and in women - 25 % of body weight, body mass index (BMI) is more than 25-30). Obesity can also be described as a metabolic disorder in individuals with genetic predisposition leading to excessive deposition of fat in the body weight, overweight being more than 10 % compared to the physiological norm, and may be accompanied by fatty degeneration of internal organs - heart, liver, kidneys.
THE CURRENT STATUS OF ETIOPATHOGENESIS OF THE PATHOLOGY LEADING TO DESTRUCTION OF OSSICULAR CHAIN (literature review)
Authors: Novoseletsky V. A. , Khorov O. G.
Published: February 2022

The article presents the current status of etiopathogenesis of the basic pathologic processes leading to destruction of ossicular chain, in particular chronic purulent otitis media common among population.
MORPHOFUNCTIONAL INDICATORS OF CITY SCHOOLCHILDREN
Authors: Abramovich M. A. , Zhdanovich V. N. , Andreychikov D. Y.
Published: February 2022

Objective: to assess the degree of development of morphological and functional indicators of city schoolchildren. Material and methods. The study involved schoolchildren aged 10, 12, 13, by 100 people in each age category. During the study we carried out qualitative and quantitative measurements of height, weight, chest excursion, head circumference, carpal dynamometry and spirometry using the Erismann and Pine index. Results. It was revealed that the majority of city girls and boys had deviations from the standard values in terms of the Erismann and Pine index. Conclusion. The studies have shown that the majority of schoolchildren have abnormalities in somatometric and physiometric indicators. The reasons for that may be unfavorable ecological situation in Gomel, poor diet, not enough active lifestyle, and genetic predisposition to a certain type of body type.
THE KEY DETERMINANTS OF MEN'S HEALTH (message II)
Authors: Semutenko K. M. , Cheshyk I. A. , Sharshakova T. M.
Published: February 2022

Objective: to determine the key determinants of health status of the male population. Material. Publications containing information about the key factors influencing the men’s health. Methods. Analysis, processing and classification of the data. Results and discussion. The article determines and systematizes factors that may affect the health of the male population, assesses the degree of modifiability of these factors and the possibility of further practical application of the received information. Conclusion. Most of the factors detected in the article are modifiable. Their correction with the help of training, changes in laws or other evidence-based methods can improve the health of the male population.
THE EFFICIENCY AND COST OF LOCAL HYPOTENSIVE THERAPY IN PATIENTS WITH PRIMARY OPEN-ANGLE GLAUCOMA IN CIS
Authors: Kuroyedov A. V. , Abysheva L. D. , Avdeyev R. V. , Alexandrov A. S. , Basinsky A. S. , Blyum E. A. , Brezhnev A. Yu. , Gazizova I. R. , Galimova A. B. , Gaponko O. V. , Garkavenko V. V. , Getmanova A. M. , Gorodnichy V. V. , Gorshkova M. S. , Gusarevitch A. A. , Diordiychuk S. V. , Dorofeyev D. A. , Zhavoronkov S. A. , Zavadsky P. Ch. , Zakhidov A. B. , Zvereva O. G. , Karimov U. R. , Kulik A. V. , Lanin S. N. , Lovpache Dzh. N. , Loskutov I. A. , Molchanova E. V. , Nefedov N. A. , Ogorodnikova V. Yu. , Onufrichuk O. N. , Petrov S. Yu. , Rozhko Yu. I. , Sidenko T. A. , Tashtitova L. B. , Khudzhatova M. S.
Published: February 2022

Objective: to determine the efficiency of the treatment for glaucoma and its accompanying costs in patients with II-III stages of open-angle glaucoma. Material and methods. The multicenter study which was conducted by 35 investigators in 29 clinical centers in 4 CIS countries from December 2013 to April 2014 took into account the results of the treatment of 115 patients (187 eyes) with glaucoma. The cost and «cost-effectiveness» of the intraocular pressure (IOP)-lowering treatment were calculated with the account of IOP-level compensation. Results. The average cost-effectiveness was 13.94 ± 0.66 rubles/day, which was comparable to the theoretical cost of the treatment but 32 % exceeded the price that patients actually paid for the treatment. As for the monotherapy with prostaglandin preparations and the fixed combination of beta-adrenoblocker and prostaglandin analogue (BB + PG), the difference between the actual price and cost-effectiveness was 44 %. At the same time, this difference in the application of the fixed combination of beta-adrenoblocker and carbonic anhydrase inhibitor (BB + CAI) made up 64 %. Conclusion. It is cheaper to achieve a controlled IOP level in the application of the fixed combination BB + PG compared to the BB + CAI fixed combination treatment.
THE FEMORAL VEIN AS PATCH MATERIAL FOR CAROTID ENDARTERECTOMY: FIRST EXPERIENCE
Authors: Pechenkin A. A. , Lyzikov A. A. , Yurgel A. V.
Published: February 2022

Cardiovascular diseases are one of the leading causes of disability and mortality in the world. Stenosing processes in the branches of the aortic arch associated with atherosclerosis are one of the basic causes of the pathology because in 50 % cases they lead to ischemic lesions of the cerebrum. The surgery of the pathology of the carotid artery lesions (carotid endarterectomy) has proved to be a safe method of prevention and correction of chronic cerebrovascular insufficiency related to atherosclerosis. At present, the techniques are well developed. However, the recurrent lesions of the area of the surgery appear in 0.9 - 36 % regardless of the types of the surgery and patch material. This fact proves the necessity of further investigation and seeking of other methods of surgical correction and alternative patch. The work studies the results of the application of the femoral vein as patch material for carotid endarterectomy. We performed the comparative analysis of the application of the most common plastic materials (GSV and PTFE) used for plastic surgery of brachiocephalic arteries in carotid endarterectomy.
Estradiol (Imvexxy)
Authors: Reimbursement Team
Published: February 2022

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.

The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.

This review assesses estradiol (Imvexxy), 4 mcg and 10 mcg, vaginal inserts.

Indication: For the treatment of postmenopausal moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy.
Primary and secondary ice production: interactions and their relative importance
Authors: Zhao Xi , Liu Xiaohong
Published: February 2022

Abstract. A discrepancy of up to 5 orders of magnitude between ice crystal and ice
nucleating particle (INP) number concentrations was found in the
measurements, indicating the potentially important role of secondary ice
production (SIP) in the clouds. However, the interactions between primary
and SIP processes and their relative importance remain unexplored. In this
study, we implemented five different ice nucleation schemes as well as
physical representations of SIP processes (i.e., droplet shattering during
rain freezing, ice-ice collisional break-up, and rime splintering) in the
Community Earth System Model version 2 (CESM2). We ran CESM2 in the single
column mode for model comparisons with the DOE Atmospheric Radiation
Measurement (ARM) Mixed-Phase Arctic Cloud Experiment (M-PACE) observations. We found that the model experiments with aerosol-aware ice nucleation schemes
and SIP processes yield the best simulation results for the M-PACE
single-layer mixed-phase clouds. We further investigated the relative
importance of ice nucleation and SIP to ice number and cloud phase as well
as interactions between ice nucleation and SIP in the M-PACE single-layer
mixed-phase clouds. Our results show that SIP contributes 80 % to the
total ice formation and transforms ∼30 % of pure
liquid-phase clouds simulated in the model experiments without considering
SIP into mixed-phase clouds. The SIP is not only a result of ice crystals
produced from ice nucleation, but also competes with the ice nucleation by
reducing the number concentrations of cloud droplets and cloud-borne dust
INPs. Conversely, strong ice nucleation also suppresses SIP by glaciating
mixed-phase clouds and thereby reducing the amount of precipitation
particles (rain and graupel).
The role of organic acids in new particle formation from methanesulfonic acid and methylamine
Authors: Zhang Rongjie , Shen Jiewen , Xie Hong-Bin , Chen Jingwen , Elm Jonas
Published: February 2022

Abstract. Atmospheric organic acids (OAs) are expected to enhance
methanesulfonic acid (MSA)-driven new particle formation (NPF). However, the
exact role of OAs in MSA-driven NPF remains unclear. Here, we employed a
two-step strategy to probe the role of OAs in MSA–methylamine (MA) NPF.
Initially, we evaluated the enhancing potential of 12 commonly detected OAs
in ternary MA–MSA–OA cluster formation by considering the formation free
energies of the (MSA)1(MA)1(OA)1 clusters and the atmospheric
concentrations of the OAs. It was found that formic acid (ForA) has the
highest potential to stabilize the MA–MSA clusters. The high enhancing
potential of ForA results from its acidity, structural factors such as no
intramolecular H bonds, and high atmospheric abundance. The second step is to
extend the MSA–MA–ForA system to larger cluster sizes. The results indicate
that ForA can indeed enhance MSA–MA NPF at atmospheric conditions (the upper
limited temperature is 258.15 K), indicating that ForA might have an
important role in MSA-driven NPF. The enhancing effect of ForA is mainly
caused by an increased formation of the (MSA)2(MA)1 cluster, which
is involved in the pathway of binary MSA–MA nucleation. Hence, our results
indicate that OAs might be required to facilitate MSA-driven NPF in the
atmosphere.
Laboratory evaluation of the scattering matrix of ragweed, ash, birch and pine pollen towards pollen classification
Authors: Cholleton Danaël , Bialic Émilie , Dumas Antoine , Kaluzny Pascal , Rairoux Patrick , Miffre Alain
Published: February 2022

Abstract. Pollen is nowadays recognized as one of the main
atmospheric particles affecting public human health as well as the Earth's
climate. In this context, an important issue concerns our ability to detect
and differentiate among the existing pollen taxa. In this paper, the
potential differences that may exist in light scattering by four of the most
common pollen taxa, namely ragweed, birch, pine and ash, are analysed in the
framework of the scattering matrix formalism at two wavelengths
simultaneously (532 and 1064 nm). Interestingly, our laboratory experimental
error bars are precise enough to show that these four pollen taxa, when embedded
in ambient air, exhibit different spectral and polarimetric light-scattering
characteristics, in the form of 10 scattering matrix elements (5 per
wavelength), which allow each to be identified separately. To end with, a simpler
light-scattering criterion is proposed for classification among the four
considered pollen taxa by performing a principal component (PC) analysis, which
still accounts for more than 99 % of the observed variance. We thus
believe this work may open new insights for future atmospheric pollen
detection.
Full-coverage 1 km daily ambient PM2.5 and O3 concentrations of China in 2005–2017 based on a multi-variable random forest model
Authors: Ma Runmei , Ban Jie , Wang Qing , Zhang Yayi , Yang Yang , Li Shenshen , Shi Wenjiao , Zhou Zhen , Zang Jiawei , Li Tiantian
Published: February 2022

Abstract. The health risks of fine particulate matter (PM2.5) and ambient ozone
(O3) have been widely recognized in recent years. An accurate estimate
of PM2.5 and O3 exposures is important for supporting health risk
analysis and environmental policy-making. The aim of our study was to
construct random forest models with high-performance and estimate daily
average PM2.5 concentration and O3 daily maximum of 8 h average
concentration (O3-8 hmax) of China in 2005–2017 at a spatial resolution
of 1 km × 1 km. The model variables included meteorological variables,
satellite data, chemical transport model output, geographic variables and
socioeconomic variables. Random forest model based on 10-fold cross-validation was established, and spatial and temporal validations were
performed to evaluate the model performance. According to our sample-based
division method, the daily, monthly and yearly estimations of PM2.5
from test datasets gave average model-fitting R2 values of 0.85, 0.88
and 0.90, respectively; these R2 values were 0.77, 0.77 and 0.69 for
O3-8 hmax, respectively. The meteorological variables and their lagged
values can significantly affect both PM2.5 and O3-8 hmax
estimations. During 2005–2017, PM2.5 concentration exhibited an overall downward
trend, while ambient O3 concentration experienced an upward trend. Whilst the spatial
patterns of PM2.5 and O3-8 hmax barely changed between 2005 and
2017, the temporal trend had spatial characteristics. The dataset is
accessible to the public at https://doi.org/10.5281/zenodo.4009308
(Ma et al., 2021a), and the shared dataset of Chinese Environmental Public Health Tracking (CEPHT, 2022) is available at
https://cepht.niehs.cn:8282/developSDS3.html.
The PFLOTRAN Reaction Sandbox
Authors: Hammond Glenn E.
Published: February 2022

Abstract. As modern reactive transport simulators evolve to accommodate the demands of a user community, researchers need a platform for prototyping new biogeochemical processes, many of which are niche and specific to laboratory or field experiments.
The PFLOTRAN Reaction Sandbox leverages modern, object-oriented Fortran in an attempt to provide such an environment within an existing reactive transport simulator.
This work describes the PFLOTRAN Reaction Sandbox concept and implementation through several illustrative examples.
Reaction Sandbox Biodegradation Hill customizes the existing microbially mediated biodegradation reaction formulation within PFLOTRAN to better match empirical data.
Reaction Sandbox Simple provides an isolated environment for testing numerous preconfigured kinetic rate expressions and developing user intuition.
Reaction Sandbox Example serves as a template for creating new sandboxes within PFLOTRAN.
Importance of different parameterization changes for the updated dust cycle modelling in the Community Atmosphere Model (version 6.1)
Authors: Li Longlei , Mahowald Natalie , Kok Jasper , Liu Xiaohong , Wu Mingxuan , Leung Danny , Hamilton Douglas , Emmons Louisa , Huang Yue , Meng Jun , Sexton Neil , Wan Jessica
Published: February 2022

Abstract. The Community Earth System Model (CESM; version 2.1) simulates the lifecycle (emission, transport, and deposition) of mineral dust and its interactions with physio-chemical components to quantify the impacts of dust on climate and the Earth system. The accuracy of such quantifications relies on how well dust-related processes are represented in the model. Here we update the parameterizations for the dust module, including those on the dust emission scheme, the aerosol dry deposition scheme, the size distribution of transported dust, and the treatment of dust particle shape. Multiple simulations were undertaken to evaluate the model performance against diverse observations, and to understand how each update alters the modeled dust cycle and the simulated dust direct radiative effect. The model-observation comparisons suggest that substantially improved model representations of the dust cycle are achieved primarily through the new more physically-based dust emission scheme. In comparison, the other modifications except the size distribution of dust in the coarse mode induced small changes to the modeled dust cycle and model-observation comparisons. We highlight which changes introduced here are important for which regions, shedding light on further dust model developments required for more accurately estimating interactions between dust and climate.
AR METHODS FOR THE VISUALIZATION OF THE LOST MARBLE “TRIBUNA” IN THE MAIN APSE OF THE CATHEDRAL OF PALERMO
Authors: Cannella M.
Published: February 2022

Abstract. In recent years research works have shown that augmented reality tools can offer effective support for the dissemination of architectural heritage, when integrated into the information data extracted with surveying and representation tools and further data from other sources, e.g., history.The development and permanent updating of software platforms dedicated to augmented reality, i.e., Apple's ARKit and Google's ARCore, as well as the introduction of new features, offer today affordable support for the development of AR solutions.Some operational difficulties are due to the rapid and constant evolution of the technologies; the available solutions can be compared to prototypes and the development of user experience effective solutions appears still lacking. The main subject in the construction of AR solutions is still linked to the development of effective methods to properly set up the visualization of 3D models and their interaction with the real scene. The chosen case study for the test of persistent AR solution for the visualization of works of art is the ‘Tribuna’, i.e., a monumental and sculptural marble apparatus, that decorated the main apse of the Cathedral of Palermo.
MULTISENSOR DATA FUSION FOR CULTURE HERITAGE ASSETS MONITORING AND PREVENTIVE CONSERVATION
Authors: Cera V.
Published: February 2022

Abstract. This paper shows the first phase of an ongoing interdisciplinary research project aimed at codifying procedures for the control and non-destructive analysis of the conservation status of CH artefacts to guide preventive preservation actions. It specifically explains the results of an experiment aimed at defining the procedural phases of semantic-informative enrichment of a digital architectural model where the morpho-metric components acquired with instrumental survey techniques are linked with cognitive and technical aspects (microclimatic, material, and geometric deviation data), with the aim of making this model a support for the simulation of scenarios connected to preventive preservation programmes.The research was carried out on the church of San Michele Arcangelo in Padula, affected by plaster detachment from the frescoes on the intrados of the vaulted systems. The work was conceived to support a mainly qualitative assessment regarding a possible relationship between micro-environmental variations and visually perceived degradation phenomena to provide a first indication of the conservation status of the investigated surfaces. The analyses were conducted through algorithms that, as such, are repeatable and objective. In addition, these processes, as they were applied to the models derived from the architectural survey, made it possible to make the most of these outputs. Therefore, by combining the algorithmic manipulation of the digital representations with the necessary critical interpretation of the data by the specialist, it was possible to address some actions of direct intervention and guide the most appropriate choices for subsequent in-depth diagnostics, more targeted, reducing the damage to the historical heritage.
THE AMBON OF SANT’ANDREA IN PISTOIA: A COMPARISON BETWEEN LASER SCANNER AND PHOTOGRAMMETRIC DIGITIZATION OF MARBLE SURFACES
Authors: Conti A. , Fiorini L. , Tucci G.
Published: February 2022

Abstract. The ambon by Giovanni Pisano in the church of Sant'Andrea in Pistoia (Italy) consists of a hexagonal platform raised on slender columns standing on bases and sculptures with different heights. In the 17th century, it was disassembled and placed in a different location and, also for this reason, is currently in an endangered condition. As part of a multi-disciplinary programme of investigations and monitoring, a 3D survey was requested. The challenging aspect of the survey is related with the material of the work of art, as it is completely made of different kinds of white and red marbles. These materials are translucent and light diffuses through them, so the laser beam scatters beyond the surface and biases measurements in an unpredictable way. Tests were carried out, comparing two scanners with different characteristics and digital photogrammetry. The results show significant differences between the three technologies, identify the best solution in relation to the desired objectives, and highlight how different acquisition techniques affect the suitability of models for subsequent applications.