bluuebunny/crossref_metadata_2025 huggingface dataset:
Korelasi Tingkat Pengetahuan Feeding Rules Ibu dengan Status Gizi Batita
Authors: Meivita Dewi Purnamasari  , Gita Sabrina Pratiwi  , Aprilia Kartikasari
Published: May 2023

Background: Knowledge can influence behaviour. Feeding is a factor that affect nutritional status of children. This study aims to describe the relationship between the level of mother’s knowledge about feeding rules and the nutritional status of toddlres.Methods: This study used a cross-sectional method. This research was conducted at the posyandu in Bancarkembar area with a total sampling technique. The number of samples is 68 respondents who meet the inclusive criteria. The research was conducted by giving a questionnaire the level of mother’s knowledge about feeding rules and antropometric measurements (weight and length) on toddlers to determine the nutritional status of toddlers. The two variables were tested for correlation using Sommers’d.Results: The results showed that there was a relationship between the level of mother’s knowledge about feeding rules and the nutritional status of toddlers with p-0,042 (p<0,05).Conclusion: The level of mother’s knowledge about feeding rules is related to the nutritional status of toodlers. This research recommends feeding rules education to mothers.
PENGARUH GADGET TERHADAP KETERLAMBATAN BICARA PADA ANAK DI ERA PANDEMI COVID-19
Authors: Kusdaryanto Wahyu Dwi , Agustina Nenden Nursyami , Wisesa Sindhu
Published: May 2023

Latar Belakang: Penggunaan gadget meningkat selama pandemi covid-19, hal ini berpotensi mengganggu tumbuh kembang bicara anak karen efeknya Tujuan Penelitian: mengetahui hubungan peranan gadget terhadap keterlambatan bicara pada anak di massa pandemi Metode: penelitian ini merupakan penelitian potong lintang studi kasus dan kontrol dengan kelompok kasus anak dengan gangguan biacar dan kelompok kontrol anak yang tidak mengalami gangguan bicara  Hasil: Screen time gadget dari 2 jam dalam 1 hari meningkatkan resiko 3x terjadi gangguan bicara pada anak Kesimpulan. Perlu pendampingan dan kontrol orang tua saat anak sedang di depan gadget
Authors: Aldina G Aldina G , Sultrasari D Setyah , Zahra S Shabrina Nur , Salsabila H Adhela , Permata S Licha , Yunita K Yunita K , Hanan S Nadya , Sascha P Diva , Nur A Ridha , Widyaningsih Pratiwi Nur , Purnama Ryana Budi , Wardana Tirta
Published: May 2023

Periodontitis is an infectious disease of the supporting tissues of the teeth caused by microorganisms, and the progressive destruction of the periodontal tissues occurs. Porphyromonas gingivalis bacteria dominate periodontitis. These bacteria can stimulate pro-inflammatory cytokines, one of which is TNF- which is part of the pathogenesis of infection through the mechanism of phagocytic cells that will play a role in periodontitis disease. Periodontitis treatment can be done by scaling root planning and giving herbal medicines, one of which is lime. This plant is useful as anti-inflammatory, antipyretic and antibacterial. Lime contains saponin and flavonoid compounds, namely hesperidin, tangerine, naringin, ericocitrin, eriocitroid.Objective: The purpose of this study was to determine the relationship of flavonoids to the synthesis of TNF- in chronic periodontitis, which was analyzed by bioinformatics through three websites, namely PubChem, stitch, and string.Method: The method used in this study is the in silico method.Results and conclusions: The content of flavonoids in lime peel has been shown to have a relationship with the synthesis of TNF-α, namely rutin. Rutin belongs to the flavonol group, which is located at position 3 on the C . ring. The aromatic group in ring B is the group that is responsible for the activity of flavonols because the conjugated double bonds at numbers 2′ and 3′ can transfer electrons from ring B to free radicals and break free radicals.
REVIEW SLEEP AND SLEEP DEPRIVATION
Authors: Yusan Rizak Tiara , Fadlilah Synta Haqqul
Published: May 2023

Sleep is a sedentary mental and physical condition. Sleep is necessary for emotional, physical, and cognitive well-being and accounts for approximately one-third of a person's life. Sleep happens in cycles in which the body alternates between two modes: REM sleep and non-REM sleep. Behavioural observation, physiological monitoring, or a mix of the two can be used for the assessment of sleep and wake. Current clinical recommendations for scoring PSGs describe three phases of progressively. The majority of hormones in plasma show strong 24-hour cycles, highlighting the significance of the circadian clock and sleep-related impacts on hormone release and/or metabolism. Lack of sufficient sleep for duration or quality might affect one's ability to function normally and maintain good health. The typical adult requires seven or more hours of sleep each night to be healthy. This report will inform the current state of the science of sleep and sleep deprivation.
Assessing the Value of Multimodal Interfaces: A Study on Human-Machine Interaction in Weld Inspection Workstations
Authors: Chojecki Paul , Strazdas Dominykas , Przewozny David , Gard Niklas , Runde Detlef , Hoerner Niklas , Al-Hamadi Ayoub , Eisert Peter , Bosse Sebastian
Published: May 2023

Multimodal user interfaces promise a natural and intuitive human machine interactions. But is the extra effort for the development of a complex multi-sensor system justified, or can users also be satisfied with one input modality already? This study investigates interactions in an industrial weld inspection workstation. Three unimodal interfaces, including spatial interaction with buttons augmented on a workpiece or a worktable, and speech commands, were tested individually and in a multimodal combination. Within the unimodal conditions, users preferred the augmented worktable, but overall, the interindividual usage of all input technologies in the multimodal condition was ranked best. Our findings indicate that the implementation and use of multiple input modalities is valuable, and that it is difficult to predict the usability of individual input modalities for complex systems.
Framework for Representing, Building and Reusing Novel State-of-the-art 3D Object Detection Models in Point Clouds Targeting Self-Driving Applications
Authors: Silva António Linhares , Oliveira Pedro , Durães Dalila , Fernandes Duarte , Névoa Rafael , Monteiro João , Melo-Pinto Pedro , Machado José , Novais Paulo
Published: May 2023

The rapid development of Deep Learning brought novel methodologies for 3D Object Detection using LiDAR sensing technology. These improvements in precision and inference speed performances lead to notable high performance and real-time inference, which is especially important for self-driving purposes. However, the developments carried by these approaches overwhelm the research process in this area since new methods, new technologies, and software versions lead to different project necessities, specifications and requirements. Moreover, the improvements brought by the new methods may be due to improvements in newer versions of deep learning frameworks and not just the novelty and innovation of the model architecture.
Thus, it became crucial to create a framework with the same software versions, specifications and requirements that accommodate all these methodologies and allow the easy introduction of new methods and models.
A framework is proposed that abstracts the implementation, reusing and building of novel methods and models. The main idea is to facilitate the representation of state-of-the-art (SoA) approaches and simultaneously encourage the implementation of new approaches by reusing, improving and innovating modules in the proposed framework, which has the same software specifications to allow a fair comparison. This makes it possible to determine if the key innovation approach outperforms the current SoA by comparing models in a framework with the same software specifications and requirements.
Next Generation Probiotics Relevance to Neurodegenerative Diseases: Novel Therapeutic Perspective
Authors: Bi Mingxia , Liu Chang , Wang Yulin , Liu Shuang-Jiang
Published: May 2023

Increasing clinical and preclinical evidences implicate gut microbiome (GM) dysbiosis as a key susceptibility factor for neurodegenerative disorders, including Alzheimer’s disease (AD) and Parkinson’s diseases (PD). In recent years, neurodegenerative diseases have not been viewed as driven solely by defects in brain, and the role of GM in modulating the central nervous system function via gut-brain axis has attracted considerable interest. Encouraged by GM researches, the next-generation probiotics may lead to tangible impacts on the treatment of neurodegenerative disorders. This review summarizes the current understandings of GM composition and characteristics associated with neurodegenerative diseases, and the demonstrations of molecules from GM affecting neurodegeneration. Particularly, applications of next-generation probiotics such as Clostridium butyricum, Akkermansia muciniphila, Faecalibacterium prausnitzii, and Bacteroides fragilis for remediation of neurodegenerative diseases are discussed.
Perubahan Arah Kiblat Masjid dalam perspektif Fiqh dan Astronomi
Authors: Amiruddin Amiruddin , Jamaluddin Jamaluddin
Published: May 2023

Studi Tentang Perubahan Arah Kiblat Masjid Di Kota Samarinda (Perspektif Fiqh Dan Astronomi). Penelitian ini dilatar belakangi tersebut, untuk mengetahui bagaimana Perubahan arah kiblat yang dipertentangkan dengan mengujinya  berdasarkan Ilmu Hisab atau Ilmu Falak melalui rumus-rumus Ilmu Ukur Segi Tiga Bola. Pertentangan tersebut terjadi di Samarinda Provinsi Kalimantan timur. Pertentangan terjadi pada dua kelompok masyarakat dengan dua  arah kiblat yang masing-masing mereka perpegang dan mereka pertahankan. keadaan tersebut tentu tidak dapat menyelesaikan persoalan yang ada. Bagi orang-orang yang berada di sekitar Mesjid al-Haram, persoalan kiblat ini tidak ada masalah, namun bagi orang-orang yang jauh dari Mekkah, hal ini dapat menimbulkan masalah yang kadang menjadi pertentangan. Data yang terkumpul kemudian dianalisis dengan menggunakan teknik deskriptif-analitik yaitu terlebih dahulu menggambarkan persoalan perubahan arah kiblat pada Mesjid yang diteliti, dari gambaran tersebut kemudian dijadikan fakta, untuk selanjutnya dianalisis berdasarkan beberapa pendekatan yaitu pendekatan syari’ah, pendekatan astronomi dan pendekatan historis, sehingga diperoleh beberapa kesimpulan. Dari hasil penelitian terlihat bahwa perubahan arah kiblat Mesjid An- Najah Ar-Rahman, Masjid Al-Ikhlas, Masjid Babussalam, Masjid Darul Ibadah, dan Masjid Al Misbah tidak akurat, disebabkan beberapa problem, pertama sikap panut terhadap ulama atau tokoh kharismatik tanpa melihat apakah ulama atau tokoh tersebut mengetahui tentang Ilmu Hisab, kedua pemakaian kompas yang cukup sederhana tanpa memperhatikan kaedah-kaedah penggunaan kompas.Hasil penelitian membuktikan bahwa terdapat variasi selisih atau penyimpangan arah kiblat sebesar : Untuk penggunaan kompas Mekkah, selisih terbesarnya adalah 20 00’ dengan penyimpangan arah sejauh 2.220 kilometer pada garis bujur (Utara – Selatan) dari arah Bait Allah, dan 2.060  kilometer pada garis lintang (Barat – Timur) dari arah Bait Allah.Untuk penggunaan kompas Nagara, selisihnya adalah 2 30’ dengan penyimpangan arah sejauh 277 kilometer pada garis bujur (Utara – Selatan) dari arah Bait Allah, dan 258 kilometer pada garis lintang (Barat – Timur) dari arah Bait Allah.

 

Kata kunci : arah kiblat, persfektif fiqh dan astronomi, Kota Samarinda.
Tinjauan Maqasyid Syariah Terhadap Praktik Pramuniaga Muslim Di Pasar Pagi Samarinda Dalam Melakukan Sholat Jumat
Authors: Muh Idris Kasri Ana , Materan Materan
Published: May 2023

latar belakang penelitian ini adalah shalat Jum'at adalah fardu'ain atau wajib atas individu, dalam arti tidak bisa diwakilkan. Ia wajib bagi muslim laki-laki yang baligh (dewasa), sehat jasmani dan rohani, tidak sedang berpergian dan merupakan penduduk tetap suatu daerah tempat dirinya melakukan shalat Jum'at. Penelitian ini menggunakan penelitian hukum empiris normatif dengan menggunakan metode penelitian Kualitatif yaitu penelitian yang berdasarkan pada filsafat positivisme atau interpretif, digunakan untuk meneliti kondisi objek yang alamiah, dimana peneliti adalah sebagai instrumen kunci. Hasil dari penelitian di simpulkan bahwa praktek pramuniaga muslim dalam melaksanakan sholat Jumat di pasar pagi Samarinda di lakukan secara bergilir setiap dua Minggu sekali. Maksud dari sholat Jumat bergilir yaitu di dalam toko memiliki karyawan yang harus di bagi dua, dalam 1 bulan berselang dua Minggu untuk bergantian melaksanakan sholat Jumat.
PENGARUH HUKUM ADAT TERHADAP KETENTUAN WARIS PASAL 183, 185, DAN 209 KOMPILASI HUKUM ISLAM PERSPEKTIF TEORI RECEPTIO A CONTRARIO
Authors: Kasumawati Devi
Published: May 2023

The presence of Kompilasi Hukum Islam (KHI) which in the beginning was anticipated as a source of Islamic civil law after releasing in Indonesia having such a pro and contra. That’s because there are some provisions that don’t fit with the classical fiqh books. Though it is said that KHI in the formulation is based on a study of the books of fiqh, especially Shafi’i. According to several parties, like Habiburrahman in his research, there are elements of customary law comes in, especially in the chapters concerning about inheritance.

Based on the statement that KHI was influenced by customary law, this research aims (1) to study KHI subsection 183 about the division of inheritance peacefully, subsection 185 about representation of heirs, and subsection 209 about obligatory bequests for adopted children; (2) how is the influence of customary law against those three articles of KHI on perspective of Receptio a Contrario Theory.

This research was classified into normative research. Used data is secondary data. The process of gathering data using documentation methode according to the conceptual approach. Data was analyzed by descriptive qualitative methode. As for verifying the validity of the data using triangulation techniques.

The result of research showing that subsection of 183 about division of inheritance peacefully has something in common with the tradition of Indonesian society that share their inheritance deliberately. While subsection 185 about representation of heirs was reflected family system which adopted by the majority of Indonesian society, with the name bilateral system. It can be seen from the possibly of replacement the heirs for orphaned grandchildren from deceased mother, which is not accommodated in the classical Islamic inheritance system. Subsection 209 about obligatory bequests for adopted children is an alternative solution for adopted children who didn’t get a share when his/her adoptive parents died. This policy is enforced due to the practice of adoption is something usual in Indonesia. According to the Receptio a Contrario theory, the customary law can be accepted if only it’s not contradictory with Islamic law. Based on the study which researchers did, although all three subsection are influenced by customary law, but the values that contained in there already accordance with the Islamic law.
PANDANGAN ORANG TUA TERHADAP PENENTUAN BATAS USIA MINIMAL DAN MAKSIMAL PERNIKAHAN PADA PEREMPUAN DI KELURAHAN LOK BAHU
Authors: Dini Rahma , Sofyan Akhmad
Published: May 2023

Differences in parents' views on determining the minimum and maximum age limits for marriage for women in Lok Bahu Village.Parents have different views on determining the minimum age limit for marriage for women in terms of the level of education they have. The minimum age limit set by parents is 17-19 years and the maximum age is 28-30 years. The minimum age limit for marriage is regulated in Law Number 16 of 2019 concerning Marriage, which is to be 19 years old for both men and women. Based on this, the researchers formulated the problem of how the views of parents with low and high education on determining the minimum and maximum age limits for marriage for women in Lok Bahu Village and what factors influence parents in determining the minimum and maximum age limits for marriage for women in Lok Bahu. This study uses empirical legal research, namely research obtained from experience, discoveries, and observations made to obtain field data. The qualitative data analysis technique used in this study uses data analysis techniques according to Miles and Huberman including, collecting data, reducing data, presenting data and drawing conclusions from the data obtained. Thus, it is hoped that the community will prioritize the level of education first before marrying off their daughters.
MAQASID SYARIAH DAN UPAYA BADAN KEPENDUDUKAN DAN KELUARGA BERENCANA NASIONAL DALAM PENGENDALIAN PENDUDUK DI KALIMANTAN TIMUR
Authors: Ramdayani Yulika , Pagala Ashar , Hasan Maisyarah Rahmi
Published: May 2023

Artikel ini akan membahas tentang upaya BKKBN Kaltim dalam menyikapi tingginya angka kelahiran total (TFR) Kalimantan Timur yang belum mencapai target 2,14 angka TFR. Tujuan penelitian mengetahui upaya yang dilakukan BKKBN Kalimantan Timur dalam amanat Undang-Undang No.59 Tahun 2009 tentang Perkembangan Kependudukan dan Pengembangan Keluarga, serta kendala yang dihadapi dan aspek maslahat terhadap upaya-upaya tersebut. Jenis penelitian yang digunakan deskriptif kualitatif dengan pendekatan normatif-empiris pengumpulan data observasi, wawancara dan dokumentasi, data dikelompokkan, disaring kemudian dikaitkan perspektif Maqashid Syariah agar ditarik kesimpulan. Hasil yang diperoleh dalam upaya Pengendalian Penduduk BKKBN Kaltim berupa Pengendalian Angka Kelahiran, Penurunan Angka kematian ibu dan anak, pengembangan kualitas penduduk, Penataan persebaran dan Pengarahan Mobilitas Penduduk, Peningkatan Ketahanan Kesejahteraan Keluarga serta Penyiapan Pengaturan Perkawinan dan Kehamilan. kendala berupa Pandemi Covid 19, Kebijakan dan Pendidikan kependudukan yang belum menyeluruh, Cakupan kualitas pelayanan KB Pasca Persalinan yang belum Optimal. Serta belum ada sistem peringatan dini pada Pemerintah Daerah untuk menangani masalah kependudukan. Upaya yang dilakukan sejalan dengan Maqashid Syariah untuk mencapai kemaslahatan diantaranya pengendalian angka kelahiran serta penurunan Angka Kematian Ibu dan Anak (Hifdz Nash) Pengembangan Kualitas Penduduk berupa Program pembinaan dan edukasi remaja (Hifdz Aql), pengarahan mobilitas penduduk (Hifdz Mal) Penyiapan Pengaturan Perkawinan serta Kehamilan (Hifdz Nasl).
Pengembangan Model Stimulasi Geometri Berbasis Pendekatan SAVI (Somatic, Auditory, Visual, Intelectual) untuk Anak Usia Dini
Authors: Utami Winda Sherly , Harianja Sri Indriani
Published: May 2023

This study aims (1) to analyze the need to stimulate geometry abilities in children aged 5-6 years, (2) to determine the level of feasibility and effectiveness of the SAVI (Somatic, Auditory, Visual, Intellectual) learning model to stimulate geometric abilities in children aged 5-6 years. This research is development research that refers to the ADDIE development model (analysis, design, development, implementation, and evaluation). The test subjects in this study consisted of 101 children aged 5-6 years in Pancung Sol District, Pesisir Selatan. Collecting data with interviews, questionnaires and observation. The research results obtained were (1) in stimulating the geometric abilities of children aged 5-6 years they needed the SAVI learning model, (2) the SAVI learning model was declared feasible and effective for stimulating geometric abilities in children aged 5-6 years based on the results of the N-Gain test with a value of 0.81 or 81% which is included in the high and effective category. Recommendations for future researchers to conduct similar research by developing other learning models, so that there are many learning models that can be used to stimulate the geometry abilities of children aged 5-6 years.
Pengaruh Tekanan Panas Terhadap Kelelahan Kerja pada Pekerja Shaping Folding
Authors: Wardani Aurina Firda Kusuma , Rinawati Seviana , Dewi Anggreini Beta Citra , Firmansyah Fathoni , Marlina Endah , Rachmawati Siti
Published: May 2023

Industri makanan dengan proses produksinya menyebabkan KAK dan PAK seperti di PT. X. Hasil pengukuran tekanan panas rata-rata pada bagian shaping folding adalah 36,7 ⁰C, dan hasil pengukuran kelelahan kerja mengalami kelelahan kerja sedang. Kondisi panas yang berlebihan akan menyebabkan kelelahan dan kantuk, mengurangi stabilitas dan menyebabkan kelelahan. Tujuan dari penelitian ini adalah untuk mengetahui adakah pengaruh tekanan panas terhadap kelelahan kerja pada tenaga kerja shaping folding di Unit 2 PT. X. Penelitian ini merupakan penelitian observasi analitik dengan pendekatan cross sectional. Penelitian ini dilakukan di Unit 2 PT.WXY pada tahun 2017. Teknik pengambilan sampel yang digunakan adalah purposive sampling dengan hasil sampel sebanyak 50 orang. Instrumen penelitian untuk mengukur tekanan panas menggunakan Area Heat Stress Monitor dan kelelahan menggunakan Reaction Timer. Tekanan panas di tempat kerja dan kelelahan kerja dengan uji data statistik Pearson Product Moment. Hasil tekanan panas tertinggi 37,4 ⁰C dan kelelahan tertinggi dengan waktu reaksi 628 mili detik. Dari hasil pengukuran diketahui 34 orang mengalami kelelahan kerja sedang. Hasil analisis dengan uji Pearson Product Moment, terdapat pengaruh yang signifikan antara tekanan panas dengan kelelahan kerja (p = 0,000). Sehingga dapat disimpulkan ada pengaruh tekanan panas terhadap kelelahan kerja pada tenaga kerja bagian shaping folding di Unit 2 PT. X. Kata Kunci: Tekanan Panas, Kelelahan Kerja
Cervical cancer screening: inequality of screening, inequality of medical practice?
Authors: Druel Vladimir , Delpierre Cyrille , Ouanhnon Lisa , Bugat Marie-Eve Rougé , Grosclaude Pascale
Published: May 2023

Background Vulnerable social groups have more difficulty in accessing care and a lower quality of care. Health systems that focus on primary care appear to be more effective, efficient and equitable. However, difficulties in accessing primary care persist. We focused on primary care screening for cervical cancer by Cervico-Uterine Smear (CUS), which has been shown to be effective in reducing incidence and mortality. To analyse the population screened by CUS and the health professionals who perform these tests, and to analyse differences in access to care in socio-economic and geographical terms.Methods This was a retrospective observational study based on data from the main health insurance schemes, allowing analysis of health care consumption according to socioeconomic level, and proximity to health care services. We included women (695,694) aged 25 to 64 years in 2012 relevant to CUS. The sociodemographic and territorial indicators were age, geographical area deprivation, and the availability of gynaecological care. The analysis was performed by using multinomial logistic regression.Results 202,271 (29%) patients underwent CUS, 68% by gynaecologists and 28% by general practitioners (GPs). However, inequalities in CUS were observed, with a decrease in the number of CUS performed with age, rural location, deprivation, and sparse health care provision. GPs’ practice seemed to penalize deprived populations less.Conclusions Screening should be conducted more by GPs in primary care, thus providing better access to deprived populations. Health care should be organised more around primary care than hospital care. The specific needs of deprived populations should be considered.
Energy restriction inhibits the replication of porcine epidemic diarrhea virus in porcine intestinal epithelial cells by enhancing autophagy flux
Authors: WANG Zhipeng , ZHANG Pengfei , WANG Shuangyun , LIU Xianhui , ZHANG Xinming , LIANG Tairun , Song Changxu
Published: May 2023

Background: Porcine epidemic diarrhea virus (PEDV) that cause diarrhea, dehydration and loss of appetite mainly invade porcine intestinal epithelial cells (IECs), and the major function of IECs is the nutrition absorption and energy metabolism. PEDV infection occurs in intestinal cells and can cause malnutrition by disturbing the energy metabolism. However, whether cell metabolism can regulate PEDV infection is unclear.
Methods: Study of the effect of energy on PEDV replication by varying the concentration of glucose in the culture medium. The cells cultured in glucose free medium, which contained 2% inactivated fetal bovine serum and 100 U/ml penicillin, 100 µg/ml streptomycin, for 24h were known as complete energy limitation. Culture in medium containing 5 mM or 25 mM glucose is called incomplete energy limitation.
Results: In this study, complete energy restriction induces autophagy and inhibit the replication of PEDV in IPEC-J2. We found that complete energy restriction (0 mM Glucose) inhibited PEDV replication compared to non-complete energy restriction (5 mM and 26 mM Glucose) groups. Under energy-limited conditions, AMP-activated protein kinase (AMPK) activity was elevated, leading to inhibition of mammalian target of rapamycin (m-TOR) activity, which in turn exacerbated LC3-II accumulation and ultimately significantly induced autophagy. Under normal energy supply conditions (26 mM Glucose), the treatment of cells with two autophagy activators, AICAR and rapamycin, can enhance autophagy and inhibit the replication of PEDV. The inhibitory effect is the same as that of complete energy restriction (0 mM Glucose).
Conclusions: This suggests that complete energy restriction (0 mM Glucose) inhibits PEDV replication by stimulating AMPK-mTOR-LC3-II autophagy axis.
Nonreciprocal Nature and Magnetochiral Charge Polarization in Chiral Molecular Devices
Authors: Xiao Jiewen , Yan Binghai
Published: May 2023

The chirality--spin interaction is a fascinating topic for physicists and chemists. For example, chiral molecules like DNA generate giant spin polarization in nanodevices characterized by large magnetoresistance (MR). This phenomenon, called chirality-induced spin selectivity (CISS), paves pathways for unconventional spintronic devices and enantiomer separation. Different from ordinary transport, CISS MR violates Onsager's reciprocal relation and its physical mechanism is elusive and debated. In this work, we propose that the CISS MR is intimately related to the electric magnetochiral anisotropy (EMCA) while EMCA respects Onsager's relation. In a molecular device including a ferromagnetic electrode, the chiral molecule, as a spin polarizer, leads to EMCA in the second order response to the electric field. However, EMCA further generates extra charge accumulation in the device given the insulating nature of the molecule. Here, reversing either electrode magnetization or molecule chirality changes the charge accumulation, which we term magnetochiral charge polarization (MCCP). Then MCCP modifies the tunneling barrier, alters the tunneling resistance sensitively, and thus, leads to a higher-order MR that violates Onsager's reciprocity.
Our model reveals the deep connection between EMCA and CISS MR and explains the unusually large MR ratio and nonequilibrium nature of CISS. We predict that the molecular spin valve device exhibits a crossover from CISS-MR to EMCA when the chiral molecule turns more metallic because of losing the accumulated charge. We further anticipate CISS MR may appear in chiral molecular devices without ferromagnetic electrodes but in an external magnetic field in case EMCA and charge accumulation co-exist.
Loss of long-range co-expression is a common trait in cancer
Authors: García-Cortés Diana , Hernández-Lemus Enrique , Espinal-Enríquez Jesús
Published: May 2023

Cancer cells display common traits and enabling-characteristics previously described as the Hallmarks of Cancer. These occur alongside alterations in the regulatory mechanisms controlling gene transcription. Gene co-expression networks (GCNs) identify correlated sets of genes that might share these mechanisms. We have previously reported loss of long-range co-expression for breast, lung, and kidney cancer GCNs. Here, we extend the study to fifteen tissues. Unlike in healthy phenotypes, the highest cancer gene-pair interactions are intra-chromosomal and their strength decays with base-pair distance. Communities in tumor GCNs are strongly associated with cancer related processes along with a wide presence of adaptive immune response. Riboproteins are highly co-expressed in cancer and normal GCNs, suggesting their relevance for cell viability. The loss of long-range co-expression is not observed in other chronic diseases such as Type-2 Diabetes or Alzheimer's disease. These results suggest that the loss of long-range co-expression is a common trait in cancer.
Effect the accumulation of bioactive constituents of a medicinal plant (Salvia miltiorrhiza Bge.) by arbuscular mycorrhizal fungi community
Authors: Wu Yan-Hong , Cai Qing-Qing , Liu Min , He Dong-Mei , Chen Xin , Wang Hai , Yan Zhu-Yun
Published: May 2023

Background Arbuscular mycorrhizal fungi (AMF) form symbiotic relationships with many terrestrial plants and have attracted considerable interest as biofertilizers to improve the quality and yield of medicinal plants. Although AMFs are widely distributed in Salvia miltiorrhiza Bunge roots, there are few studies on how multiple AMFs could affect biomass and active ingredient accumulations. The purpose of this study was to comprehensively investigate the impacts of five native AMFs and twenty-six communities on the root biomass and secondary metabolites of S. miltiorrhiza.Results Thirty-one treatment groups formed symbiotic relationships with S. miltiorrhiza, according to the pot culture results, and the colonization rate ranged from 54.83–89.97%. With increasing AMF richness, root biomass and total tanshinone accumulations (ATTS) showed a rising trend, while total phenolic acid accumulations (ATP) showed a decreasing trend. This indicated that plant productivity was influenced by the AMFs richness, and the inoculation benefit was higher when the communities contained three or four AMFs. The affinities of AMF members were also connected to plant productivity. The inoculation effect of relatively closely related AMFs of the same family, such as Glomus formosanum, Septoglomus constrictum, and Rhizophagus manihotis, was consistently lower than that of mono-inoculation when any combinations were applied. The co-inoculation of S. miltiorrhiza with nearby or distant AMFs from two families, such as G. formosanum, R. manihotis, and Acaulospora laevis or Ambispora gerdemannii, increased ATP and ATTS by more than 50%.Conclusion The results show that co-inoculation of three or four distantly related AMFs improves the plant’s economic yield in an ecologically friendly manner.
GO-Tibia: a masked, randomized control trial evaluating Gentamicin versus saline in Open Tibia fractures
Authors: Haonga Billy T , O'Marr Jamieson , Ngunyale Patrick , Ngahyoma Joshua , Kessey Justin , Sasillo Ibrahim , Rodarte Patricia , Belaye Tigist , Berhaneselase Eleni , Eliezer Edmund , Porco Travis , Morshed Saam , Shearer David W
Published: May 2023

Background:
The rate of open tibia fractures is rapidly increasing across the globe due to a recent rise in road traffic accidents, predominantly in low and low-middle income countries. These injuries are orthopaedic emergencies associated with infection rates as high as 40% despite the use of systemic antibiotics and surgical debridement. The use of local antibiotics has shown some promise in reducing the burden of infection in these injuries due to increasing local tissue availability, however no trial has yet been appropriately powered to evaluate for definitive evidence and the majority of current studies have taken place in a high-resource countries where resources and the bio-burden may be different. • Methods:
This is a prospective randomized, masked, placebo-controlled superiority trial designed to evaluate the efficacy of locally administered gentamicin versus placebo in the prevention of fracture-related infection in adults (age>18 years) with primarily closeable Gustillo-Anderson class I, II, and IIIA open tibia fractures. Eight hundred and nighty patients will be randomized to receive an injection of either gentamicin (treatment group) or saline (control group) at the site of their primarily closed open fracture. The primary outcome will be the occurrence of a fracture related infection occurring during the course of the 12-month follow-up.
Discussion:
This study will definitively assess the effectiveness of local gentamicin for the prevention of fracture-related infections in adults with open tibia fractures in Tanzania. The results of this study have the potential to demonstrate a low-cost, widely available intervention for the reduction of infection in open tibia fractures.
Trial registration: Clinicaltrials.gov identifier: NCT05157126. Registered on December 14th, 2021.
An epsilon class glutathione S-transferase gene contributes to the phytochemical susceptibility of Tribolium castaneum
Authors: Gao Shanshan , Li Dongyu , Zhou Can , Zhu Min , Zhang Yonglei , Li Ruimin , Zhang Kunpeng
Published: May 2023

Evidence is accumulating that insect epsilon class glutathione S-transferases (GSTes) play an important role in the resistance of xenobiotics such as insecticide. A Tribolium castaneum epsilon class GST gene, TcGSTe17, could be significantly induced following exposure to plant derivative eucalyptol. However, whether TcGSTe17 involved in resistance to eucalyptol is still unclear. In this study, the TcGSTe17 was cloned from the T. castaneum genome, which exhibited the characteristic structural domain of epsilon class GSTs. In addition, molecular docking analysis showed that TcGSTe17 possibly could interact with eucalyptol. The expression profiling of stage showed that TcGSTe17 expressed at all development stages, of which highly expressed at late larvae. The expression profiling of tissue showed that TcGSTe17 highly expressed in gut of larvae and fat body of adults, respectively, and exhibited gender-different expression patterns as well. In addition, the transcripts of TcGSTe17 were significantly increased following exposure to eucalyptol, and RNAi heightened the susceptibility of beetles to eucalyptol. Overall, these results suggest that TcGSTe17 is required for the susceptibility of T. castaneum to eucalyptol. This study will contribute to the development of molecular targets, and provide scientific basis for developing eucalyptol as an insecticide.
Rainfall Prediction using Deep Learning and Machine Learning Techniques
Authors: sashank chittella , Raj Kiruthick , Amin Teerth Deepak , S Ayyasamy
Published: May 2023

This study focuses on the development of a tool to predict Rainfall using Neural networks. This application uses a neural network to predict precipitation based on historical weather data such as temperature, humidity, wind speed, and pressure. Models are trained on large datasets of weather information to learn the complex relationships between weather variables and precipitation. The application provides accurate and timely rainfall forecasts to help farmers plan their crops, water managers allocate resources, and responders prepare for potential floods and droughts. Overall, this application has the potential to reduce the impact of extreme weather events and improve our ability to make more informed decisions related to water resource management.
Speech Recognition Using Matlab
Authors: Gupta Ashish , Adeem Mir , Mathias Saharsh Justin , S Ayyasamy
Published: May 2023

Currently, technology is rapidly advancing to simplify people's daily lives. Our project aims to contribute to this by developing a voice recognition system that identifies the speaker and their speech, providing hands-free security that is resistant to hacking. The primary goal of this research is to create a more natural interface between humans and computers by enabling automatic speech recognition (ASR). Since people primarily communicate through speech, this technology can help remove communication barriers by allowing computers to understand human speech. To achieve this, we plan to design and implement a speech recognition system that accurately identifies a few simple commands. To recognize the speaker, we have used linear predictive parameters related to their vocal tract, along with hidden Markov models. Speech recognition is a widely used concept in security projects, as it helps confirm the identity of individuals automatically. In our project, we extract features using linear predictive coding from voice signals sampled directly from a microphone. We use Artificial Neural Networks (ANN) as the recognition method, with the codebook used as input feature vectors to the ANN. The back propagation algorithm of the ANN is used for training, and the training parameter is stored for future testing of the same speech sample.
Additionally, diabetes is a prevalent disease affecting more than 246 million people worldwide, with this number expected to rise to around 380 million by 2025. It occurs when the body is unable to generate or respond correctly to insulin, which regulates glucose. This disease increases the risk of developing heart disease, kidney disease, blindness, nerve damage, and blood vessel damage. To diagnose diabetes, proper interpretation of the diabetes data is crucial, making it an important research issue. This study used a back propagation training algorithm for logistic regression classification with the diabetes dataset from Pima Indians. The dataset is a binary classification problem where the aim is to determine whether a patient has the disease based on several features.
Interplay of Chronic Obstructive Pulmonary Disease and Colorectal Cancer Development: Unravelling the Mediating Role of Fatty Acids through a Comprehensive Multi-Omics Analysis
Authors: Zhou Youtao , Lin Zikai , Xie Shuojia , Gao Yuan , Zhou Haobin , Chen Fengzhen , Fu Yuewu , Yang Cuiyan , Ke Chuanfeng
Published: May 2023

Background: Chronic obstructive pulmonary disease (COPD) patients often exhibit gastrointestinal symptoms, and COPD is potentially associated with colorectal cancer (CRC).
Methods: We collected COPD and CRC data from the National Health and Nutrition Examination Survey, genome-wide association studies, and RNA sequence for a comprehensive analysis. We used weighted logistic regression to explore the association between COPD and CRC incidence risk. Mendelian randomization analysis was performed to assess the causal relationship between COPD and CRC, and cross-phenotype meta-analysis was conducted to pinpoint crucial loci. Multivariable mendelian randomization was used to uncover mediating factors connecting the two diseases. Our results were validated using both NHANES and GEO databases.
Results:
In the NHANES dataset, we found that COPD serves as a contributing factor in the development of CRC. MR analysis revealed that COPD increased the risk of CRC onset and progression (OR: 1.16, 95% CI: 1.01–1.36). Cross-phenotype meta-analysis identified four critical genes associated with both CRC and COPD. Multivariable mendelian randomization results indicated that body fat percentage, omega-3, omega-6, and the omega-3 to omega-6 ratio may be mediating factors impacting both CRC and COPD; these findings were confirmed in the NHANES dataset. In the RNA expression data for COPD and CRC, weighted gene co-expression network analysis and Kyoto Encyclopedia of Genes and Genomes enrichment results demonstrated a strong correlation between fatty acid–related modules in both diseases.
Conclusions: Our findings suggest that COPD may contribute to an elevated risk of CRC development through fatty acid–related pathways.
Chronic pulmonary thromboembolism and chronic aortic dissection: A surgery challenge
Authors: Peña Alvaro Diego , Estacio Mayra , Cadavid Eduardo , Olaya Hector , Moreno Alejandro , Olaya Stephany
Published: May 2023

Acute aortic dissection and acute pulmonary embolism are both life-threatening emergencies. The presented case is of a 70-year-old patient with chronic aortic dissection, an incidental finding in the pulmonary tomography during the study of chronic pulmonary thromboembolism. Initially, it was considered to carry out the two simultaneous procedures but considering her age and the fact that she had a chronic aortic dissection without root dilation, it was concluded that she had more risk than benefit from carrying out the aortic replacement procedure. For this reason, it was decided to perform only a pulmonary thromboendarterectomy, resulting in a short hospital stay with subsequent outpatient control and symptomatic improvement. This was achieved with good pre-surgical planning and without carrying out a mixed procedure with high morbidity and mortality.
Pan-cancer analysis of the prognostic and immunotherapeutic values of exostosin-1
Authors: Liu Yuqiu , Li Li , Wang Hongqing , Tian Wei , Lv Qingfeng , Zhang Yujie , Li Changzhong
Published: May 2023

Background Exostosin-1 (EXT1) is associated with the spread and metastasis of cancer cells. In this study, we investigate the prognostic value and immunological relevance of EXT1 in various cancers.Methods The expression profiles and clinical data of 33 different cancers were collected. The differences of EXT1 expression between tumor and normal tissues were analyzed using a t-test and paired t-test. Univariate Cox regression analysis was performed, and survival curves were plotted to evaluate the prognostic value of EXT1. The molecular mechanisms of EXT1 were determined, and a drug sensitivity analysis was conducted. Finally, the expression and function of EXT1 was verified in endocervical adenocarcinoma (CESC) cells.Results The Cancer Genome Atlas and Genotype-Tissue Expression databases showed that EXT1 expression was higher in CESC, cholangiocarcinoma, head and neck squamous cell carcinoma, esophageal carcinoma, kidney renal papillary cell carcinoma, liver hepatocellular carcinoma, lung squamous cell carcinoma, and stomach adenocarcinoma specimens than in normal specimens. Additionally, EXT1 expression correlated with survival time, including overall survival, disease-specific survival, disease-free interval, and progression-free interval, in multiple cancers. Functional enrichment analysis revealed that EXT1 is associated with immunity-, tumorigenesis-, and development-related pathways. Immunocorrelation analysis showed that EXT1 is related to the immune response, tumor microenvironment, and immunotherapeutic response in various cancers. Drug sensitivity analysis revealed that 152 drugs exhibited remarkably different sensitivities between the high- and low-EXT1 expression groups. Cell experiments showed that EXT1 expression was related to the proliferation, migration, and invasion of CESC tumor cells.Conclusion EXT1 is a potential target gene for immune infiltration and has prognostic value in multiple cancers; thus, it may provide new insights into cancer treatment.
Identifying the mixing-induced homogeneity characteristics of asphalt mixtures containing reclaimed asphalt pavement (RAP) materials
Authors: Wu Jiantao , Qiu Lei , Jiao Yan , Liu Quan , Jing Chao , Zhu Jinlong
Published: May 2023

The homogeneity of asphalt mixtures accounts for the pavement long-term durability, particularly for the recycled asphalt mixtures that includes reclaimed asphalt pavement (RAP) materials. Therefore, this study examined the mixing-induced homogeneity characteristics of recycled asphalt mixtures containing 40% RAP dosages. In specific, five mixing times and two ageing degrees of RAP binder were considered. The titanium dioxide powder was incorporated into RAP binders as an identification tracer. After the specimen preparation, the Computed Tomography (CT) technology was implemented to obtain the digital images of the specimen. In what follows, components of asphalt mixtures were separately identified. Accordingly, two homogeneity indexes were proposed to estimate the homogeneity of recycled asphalt mixtures. The results indicated that the distribution of the coarse aggregate contributed most to the specimen homogeneity, followed by the bitumen mastics and the air void. The extension of mixing time, to some extent, benefited the homogeneity degree of recycled asphalt mixtures. However, the newly formed clusters that occurred in the mixing process should be concerned and eliminated. For a cylinder specimen, the middle part of the specimen was more homogeneous than marginal positions.
Barriers to resilience among healthcare staff in Ireland in the post-austerity period: A cross- sectional analysis
Authors: Sanchez Arianna* Almirall , Fleming Pádraic , Layte Richard , McGowan Emer , O'Donoghue Catherine , Farsaci Liz , Thomas Steve
Published: May 2023

The health workforce is the motor of any health system. Although the focus of health systems has been on increasing the availability of health workers, less attention has been devoted to exploring the factors associated with the satisfaction/dissatisfaction of the existing workforce or how to improve them.
Objective: To assess job satisfaction among Irish healthcare workers and to model the association between psychological, sociodemographic, and work-related factors and the satisfaction of the health staff.
Methodology: A secondary data analysis and subgroup analysis were conducted utilising the data collected in the waves (2016, 2018) of the Irish Staff Survey “Your Opinion Counts”(YOC). Descriptive statistics were used to describe the baseline characteristics of the participants. Post-stratification weights were generated to decrease the bias associated with the representativeness of the sample. Ordinal logistic regression was utilised for determining associations between job satisfaction and work-related, sociodemographic, and psychological state variables.
Results: Just over half of the health staff were satisfied with their organisation (52.1%). At country and organisational levels, the communication within the organisation and the possibilities of training and career progression showed the greatest percentage of dissatisfaction within the participants. At the individual level, being a woman, experiencing bullying or discrimination, working in the National Ambulance Service or being a doctor/dentist were the variables highly correlated with dissatisfaction of health staff.
Conclusion: The results highlighted the dissatisfaction experienced by many healthcare workers. Therefore, understanding and addressing their concerns is crucial for policy makers developing national strategies and knowledge-based interventions.
SSH-DAuth: Secret Sharing based Decentralized OAuth using Decentralized Identifier
Authors: Danda Prudhvi Krishna , Radhakrishnan Ramaguru , Kanakkath Praveen , Madathil Sethumadhavan , Soundarapandian Ravichandran Kattur , Raghuraman Krishan Kumar , Gandomi Amir H
Published: May 2023

OAuth2.0 is a Single Sign-On (SSO) approach that helps to authenticate and authorize users to log into multiple applications without re-entering the credentials. In this model, the data are stored in a central repository completely controlled by the OAuth service provider, which may lead to third-party fraud and identity theft. This paper proposes a decentralized authentication framework comprised of a blockchain-based decentralized identifier and private distributed storage via an interplanetary filesystem (IPFS), permitting the user to have end-to-end data control. Furthermore, we have added a secret sharing mechanism that allows secure storage of data in our proposed model. We implemented our proposed framework in Hyperledger Indy(permissioned blockchain) and Ethereum (permissionless blockchain) to compare the efficiency, scalability, and privacy of the data stored in the blockchain ledger.