bluuebunny/crossref_metadata_2025 huggingface dataset:
Doenças inflamatórias intestinais: uma abordagem geral
Authors: Carvalho Lanna do Carmo , Silva Esaú Simões da , Roma Anna Lidía Masson , Lauriane José Eduardo Godoy , Reis Sâmella Cotrim dos , Costa Fernando Valdino Silva , Bezerra Ricardo Olavo de Carvalho , Rocha Mylena Francyele Queiroz , Filho Valmir Queiroz Mariano , Machado Lara Cândida de Sousa
Published: February 2022

Objetivo: Descrever e abordar sobre as considerações gerais e pontos mais importantes das doenças inflamatórias intestinais.  bibliográfica: As doenças inflamatórias intestinais abordam uma variedade de condições, mas o foco textual e o contexto clinico se voltam para a doença de Crohn e a retocolite ulcerativa, em função de seu caráter idiopático e autoimune, e também por apresentar um quadro clínico exuberante, fisiopatologia abrangente, semelhanças entre si e demais desordens intestinais inflamatórias e em algumas situações não se limitam só ao acometimento da porção digestiva e desencadeiam acometimentos extra-intestinais e impactam negativamente a saúde e a qualidade de vida do paciente por sintomatologias oriundas do quadro de base ou terapêutica. Considerações finais: As doenças inflamatórias intestinais possuem elevada importância clínica e mesmo com a falta de comprovações sobre o fator desencadeante e outros aspectos relevantes é possível conhecer o quadro clínico, realizar o diagnóstico diferencial e seguir uma conduta terapêutica adequada.
Correlative Analysis of Ion Concentration Profile and Surface Nanoscale Topography Changes using Operando Scanning Ion Conductance Microscopy
Authors: Takahashi Yasufumi , Takamatsu Daiko , Korchev Yuri , Fukuma Takeshi
Published: February 2022

Although various spectroscopic methods have been developed to capture the ion concentration profile changes, it is still difficult to visualize the ion concentration profile and surface topographical changes simultaneously during the charging/discharging of LIBs. To tackle this issue, we have developed an operando scanning ion-conductance microscopy (SICM) method that can directly visualize an ion concentration profile and surface topography using a SICM nanopipette whilst controlling sample potential or current by potentiostat for characterizing the polarization state during charging/discharging. Using operando SICM on the negative electrode (anode) of LIBs, we have characterized ion concentration profile changes and the reversible volume changes related to the phase transition during cyclic voltammetry (CV) and charge/discharge of the hard carbon anode. Operando SICM is a versatile technique that is likely to be of major value for evaluating correlation of the electrolyte concentration profile and nanoscale surface topography changes.
Stereocontrolled Acyclic Diene Metathesis Polymerization
Authors: Hsu Ting-Wei , Kempel Samuel , Felix Thayne Alyssa , Michaudel Quentin
Published: February 2022

The cis/trans geometry of olefins is known to dramatically influence the thermal and mechanical properties of polyalkenamers. Yet, polymerization methods that allow the practitioner to efficiently control this parameter are scarce. Herein, we report the development of a stereoretentive acyclic diene metathesis (ADMET) polymerization that capitalizes on the unique reactivity of dithiolate Ru carbenes combined with cis monomers. These Ru catalysts exhibit exquisite retention of the cis geometry and tolerate many polar functional groups, enabling the synthesis of all-cis polyesters, polycarbonates, polyethers, and polysulfites. Additionally, the stereoretentive ADMET is characterized by low catalyst loadings and tolerance toward trans impurities in the monomer batch, which should lend to ready implementation at large-scale. Remarkably, modulation of the reaction conditions including temperature and reaction time leads to an erosion of stereoretention, thereby permitting a stereocontrolled synthesis of polyalkenamers with predictable cis:trans ratios. The impact of the cis:trans alkene content within the polymer backbone on the thermal properties was clearly demonstrated through differential scanning calorimetry and thermogravimetric analysis. Stereocontrolled ADMET provides a unique synthetic approach toward materials with precise structures and tailored properties.
Property-selected Asymmetric Azobenzenes for Photoswitchable Ligands
Authors: Kuellmer Florian , Gregor Lucas , Arndt Hans-Dieter
Published: February 2022

Suitable designed photoswitches based on azobenzenes are essential structural features for photopharmacological compounds. Optimized azobenzenes are important for serving as building blocks in „azo extension“ strategies, and for designing photodrugs with tailored properties. Herein we present the synthesis and characterization of a variety of asymmetric azobenzenes by addressing selected structural features of the diazene core, such as polarity, steric demand, and electronical properties. Systematic exploration led to photoswitches with a relaxation half-life of seconds, minutes, hours, or days. Furthermore, the influence of different substitution pattern on the photophysical properties was charted. For analysis of all switches, robust characterization as well as examination under near-to physiological conditions was established, in order to assist with photoswitch choice for specific biological applications.
Functional activity of blood neutrophilic granulocytes in patients with opisthorchiasis, depending on the severity of liver fibrosis
Authors: Tsukanov Vladislav V. , Gorchilova Ekaterina G. , Kolenchukova Oksana A. , Gvozdev Ivan I. , Savchenko Andrei A. , Kasparov Eduard V. , Vasyutin Aleksandr V. , Tonkikh Juliia L. , Borisov Aleksandr G. , Rzhavicheva Olga S.
Published: February 2022

Aim. To study the activity of neutrophilic granulocytes in patients with opisthorchiasis, depending on the severity of liver fibrosis.
Materials and methods. A total of 74 patients with chronic opisthorchiasis (39 men and 35 women, average age 42.3 years) and 32 practically healthy patients (17 men and 15 women, average age 41.5 years) aged 24 to 60 years were examined. Diagnosis of opisthorchiasis was carried out by two methods: coprooscopy and identification of eggs or bodies of adult parasites in duodenal content. Liver fibrosis was determined by the method of elastometry according to the METAVIR scale in all 74 patients with opisthorchiasis. The study of the functional activity of neutrophils in the blood was performed to all 74 patients with opisthorchiasis and 32 healthy individuals from the control group by chemiluminescent analysis with measurement of the reactive oxygen species (ROS) production intensity in a spontaneous and zymosan-induced reaction in lucigenin and luminol-dependent processes.
Results. Liver fibrosis F2 by METAVIR was registered in 20.3% of the examined individuals, liver fibrosis F3F4 by METAVIR was detected in 17.6% of patients with opisthorchiasis. In patients with opisthorchiasis with liver fibrosis F3F4 by METAVIR, a significant decrease in the functional activity of neutrophilic granulocytes was registered in comparison with individuals with liver fibrosis F0F1 by METAVIR, as evidenced by a significant decrease in the maximum intensity of ROS production (Imax) and the area under the curve (S) chemiluminescence in lucigenin and luminol-dependent processes both in the spontaneous and zymosan-induced reaction.
Conclusion. These results provide new information to explain the mechanisms of liver fibrosis in patients opisthorchiasis and create opportunities for the development of diagnostics and preventive technologies.
Mixed infection: viral hepatitis A and hemorrhagic fever with renal syndrome. Case report
Authors: Bondarenko Alla L. , Protasov Alexey V. , Rokhin Evgeny A. , Slobozhaninova Yulia P.
Published: February 2022

The article considers a case from clinical practice: a mixed infection of viral hepatitis A and hemorrhagic fever with renal syndrome. Hepatitis had a protracted course and proceeded with the development of acute hepatic encephalopathy. Hemorrhagic fever was characterized by an atypical course with lung and heart damage.
Pro-inflammatory cytokines in chronic cardiac failure: state of problem
Authors: Korotaeva Alexandra A. , Samoilova Elena V. , Mindzaev Dzambolat R. , Nasonova Svetlana N. , Zhirov Igor V. , Tereschenko Sergei N.
Published: February 2022

Systemic inflammation is characterized by the induction of pro-inflammatory cytokines, the increased level of which in the blood of patients with chronic heart failure (CHF) correlates with unfavorable clinical outcomes. However, it is unclear whether pro-inflammatory cytokines are the cause or the consequence of the disease progression. CHF with preserved ejection fraction and CHF with reduced ejection fraction demonstrate different inflammatory features, which suggests different degrees of pro-inflammatory pathway activation. The review deals with participation of pro-inflammatory cytokines in pathophysiological processes of CHF development, emphasizing the role of interleukin-6 activation and the effects of accompanying diseases on the course of systemic inflammation. The search for new approaches to prevention and therapy of CHF remains actual. The review presents the results of clinical trials of targeted anti-cytokine therapy which have revealed difficulties in controlling inflammation under the conditions of CHF. Identification of specific pro-inflammatory pathways in CHF pathogenesis will allow one to control inflammatory cascades, thus providing a prospective therapeutic strategy.
Clinical portrait of a patient with COVID-19. The experience of a multidisciplinary clinic
Authors: Baimakanova Gulsara E. , Khatkov Igor E. , Dudina. Galina A. , Chegodar Anzhelika S. , Rumyantsev Konstantin A. , Sviridov Filipp S. , Osipova Alena V , Danishevich Anastasiia M. , Noskova Karina K. , Pinashina Evgeniia S. , Orlova Nataliia V. , Slezinger Viacheslav M. , Chernova Marina E. , Tovstyko Karina A. , Bodunova Natalia A.
Published: February 2022

Aim. Evaluation of the clinical characteristics in patients with COVID-19.
Materials and methods. The article presents clinical and instrumental data of 1169 patients included in a single-center mixed study. Patients were tested for COVID-19 using polymerase chain reaction, computed tomography (CT), and antibody screening. Clinical history data were collected.
Results. In patients with confirmed COVID-19, lung damage and a positive test for antibodies were observed in 75.5 and 45.2% of cases, respectively. The most common symptoms of COVID-19 were: fever (73.2%), weakness, (72.7%) dry cough (62.8%) and shortness of breath (55.4%). Patients with CT-visualized lung lesions were more likely to have clinical symptoms and elevated levels of antibodies. Patients with chronic diseases of the endocrine system, circulatory system, and respiratory system had a more severe course of the disease (CT-14: 91.296.3%) than patients without chronic diseases (CT-14: 85,1%).
Conclusion. We have compiled a clinical profile of patients with COVID-19 and highlighted the most significant clinical characteristics corresponding to a more severe course of the disease. Our data showed that patients with chronic diseases require a personalized approach and the development of specific criteria for the diagnosis and treatment of COVID-19.
The efficacy and safety of eculizumab biosimilar in patients with paroxysmal nocturnal hemoglobinuria. Results of a phase III randomized open-label comparative clinical trial
Authors: Kulagin Aleksandr D. , Bakirov Bulat A. , Davydkin Igor L. , Elykomov Ilya V. , Konstantinova Tatiana S. , Korobkin Aleksandr V. , Kosinova Marina V. , Mazurov Vadim I. , Minaeva Natalia V. , Proidakov Andrei V. , Ptushkin Vadim V. , Shatokhin Yuri V. , Lin'kova Yulia N. , Zinkina-Orikhan Arina V. , Morozova Maria A.
Published: February 2022

Aim. To establish the equivalent efficacy and comparable safety profile of biosimilar Acveris and referent eculizumab product Soliris used for the treatment of paroxysmal nocturnal hemoglobinuria (PNH).
Materials and methods. Were included in the phase III multicenter 28 PNH patients, open-label clinical trial. Participants were randomized (1:1) into 2 treatment groups: investigational product (Acveris, n=14) and referent product (Soliris, n=14). Patients received eculizumab as the intravenous infusion 600 mg once a week during the first 4 weeks, 900 mg at week 5 and then 900 mg every 14 days (2 days) up to week 27 of the study. The efficacy, pharmacokinetics, pharmacodynamics, safety and immunogenicity of the compared products were analyzed after the end of 27 weeks of the study. The primary efficacy endpoint was the area under the curve LDH concentrationtime (AUCLDH) throughout the study period weeks 527.
Results. The difference between the mean AUCLDH values between the Acveris and Soliris groups was 5380.0 [-38 773.87; 49 533.87] U/ldays. The 95% CI limits for the difference in mean AUCLDH values between the groups fit the preset 95% CI [-146 500.9146 500.9] U/ldays and establish the equivalent efficacy of the biosimilar and referent product according to the primary efficacy endpoint. The safety profile of both Acveris and Soliris was expected and comparable according to the proportion of patients with adverse events. The formation of binding antibodies to eculizumab was not detected in both the groups.
Conclusion. The study established the equivalent efficacy of biosimilar product Acveris and referent eculizumab product with the evidence of effective suppression of intravascular hemolysis in PNH patients along with a comparable favorable safety profile.
Social network-proximity association: Preliminary evaluation of giraffe sociality in a zoo-housed group
Authors: Grasso Chiara , Poso Giorgia , Lenzi Christian
Published: February 2022

Giraffes (Giraffa camelopardalis) are found in zoos all over the world. In recent years, numerous researchers have documented complex sociality in these mammals. They highlighted that giraffes have non-random preferences in their choices of social partners, which can depend on various factors such as age, sex, and kinship. One of the still little-known aspects is how the social structure of giraffes is formed in captivity. Moreover, the scientific literature about some aspects of the social structure of giraffes in captivity (i.e., proximity or affiliative interactions) is scarce. Our hypothesis was that there would be an association between the social network, based on affiliative reciprocal interactions, and physical proximity within a group of six giraffes (5 females and 1 male) living in a zoo. To test this hypothesis, in addition to the ethological observations, we also used a Geographical Information System (GIS) to study the position of the individuals within the daytime installation. Most of the giraffes had a high number of mutual dyadic interactions, which is connected to high group cohesion. Also, each individual actively selected social partners and formed non-random social bonds. Nevertheless, our hypothesis that there would be a social network–physical proximity association, was confirmed for one dyad and partially confirmed for the other two. The results of this study can be useful to increase the knowledge of giraffe sociality and to develop GIS as a new application in zoo studies.
THE ROLE OF ECOLOGICAL CONDITIONS IN THE FORMATION OF GLUTEN IN SPRING WHEAT
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, KELER V.V. , OVCHINNIKOVA T.G.
Published: February 2022

The article analyzes the results of the studies to assess the role of weather conditions in the formation of gluten in spring wheat grain in the conditions of the Krasnoyarsk forest-steppe. The researchers carried out the work based on the experiments conducted in the educational farm “Minderlinskoe” of Krasnoyarsk State Agrarian University in 2013–2021. At the present stage in Siberia, it is not always possible to equate high yields with good grain qualities. More often, there is a negative trend. In years with heavy precipitation but with a small amount of heat, high grain yields are obtained but of reduced quality. In dry years, the farmers harvest low yields with a high gluten content in the grain. They hand over the most high-quality grain in arid steppe areas. It isn’t easy to get a grain of valuable wheat in the northern forest-steppe and foothill areas, although it is possible. In the research, the authors evaluated the varieties of soft spring wheat included in the State Register of Breeding Achievements Approved for Use, cultivated in the forest-steppe of the Krasnoyarsk Territory, for gluten content and its stability over the years. The relationships of this indicator with the temperature factor, the impact of moisture availability during the growing season, and its contribution to the amount of gluten in soft spring wheat are determined. The effect of the hydrothermal coefficient by month on the above feature is estimated. The researchers found that the quantitative average gluten content in the studied varieties ranges from 29 to 33%, and its maximum amount is formed in the varieties Novosibirsk 15 and Novosibirsk 29 reaching 35%. The study of correlations of gluten content in the grain of soft spring wheat with the heat supply of the growing season revealed a positive, favorable role between the amount of gluten and average monthly temperatures. The nature of the relationship between precipitation and this sign was negative.
STRATEGIES AND METHODOLOGICAL SCHEME OF CINEMA RESEARCH. METHODOLOGY
Authors:   Russian State University for the Humanities, Schtein Sergey Yu.
Published: February 2022

In the third article from the series of works devoted to the review of existing and potentially possible algorithms for the research of cinematography, the specifics of the methodological tools necessary for the research of its various aspects are analyzed. The analysis of the methodological tools used in variant research algorithms is developed taking into account the consideration of cinematography as an object and material for cognitive activity carried out in the previous two articles (the first article of the cycle), which is implemented in relation to what can be characterized as the thing area of his disciplinary researches (second article cycle). Based on constant research goals, strategies and methodological examples of various scale researches of cinematography can be functionally used for conscious design and optimal productive implementation of cognitive activity in relation to it.
THE “PRECEPTS” OF ORPHEUS: “THE ARCHAIC” AS A CREATIVE PRINCIPLE OF SYMBOLIST ARTISTS
Authors:   Scientific Research Institute of Theory and History of Arts of the Russian Academy of Arts, Davydova Olga S.
Published: February 2022

The article undertakes a multidimensional philosophical and aesthetic analysis of symbolist artists' perception of Antiquity through the prism of visual myth-making, archaic in its inner nature. The legendary time of the poetic covenants of Orpheus before the ancient Greek classics, as well as the period of Homer's archaicism, are seen as metaphorical coordinates to separate true historical Antiquity from those images in which the modern age has found its illusory Hellas. Using examples from Western European and Russian art, succinct generalisations and, for the first time, introducing documentary material, the author concludes that the question of the “archaic” or creatively primordial (partly chaotic) beginning of the Symbolist art is the question of their relationship not so much with history as with the poetry of the ghostly past, which the modernist artists sought to awaken, to revive, hoping to find in it the true life features of their imagined artistic ideals.
Caracterización y tipos de familias productoras de maíz local en la Frailesca, Chiapas
Authors: Arias-Yero Lliana , Guevara-Hernández Francisco , La O-Arias Manuel Alejandro , Cadena-Iñiguez Pedro
Published: February 2022

Las Unidades de Producción Familiar (UPF) están conformadas por capitales natural, físico, financiero, humano y social. Los dos últimos constituyen la base del funcionamiento del resto y de la unidad de producción. En México, Chiapas y la Frailesca, la producción de maíces, particularmente de maíces locales, tiene valor cultural, agronómico y económico. El objetivo de esta investigación fue caracterizar las Unidades de Producción Familiar que cultivan maíces locales en la región Frailesca del estado de Chiapas, sobre la base cultural del manejo de los capitales humano y social. Se estudiaron 80 UPF de 20 comunidades seleccionadas mediante un muestreo por redes. Se utilizó el enfoque Modos de Vida Sustentable como marco de referencia. Se aplicaron entrevistas semiestructuradas y se realizaron observaciones participantes. En el estudio predominaron las familias nucleares con líderes de edad avanzada. Los jóvenes no priorizan la conservación de los maíces locales sino actividades más rentables como la ganadería, los maíces híbridos y el café. Existe un excesivo uso de agroquímicos que afecta los recursos suelo, agua y biodiversidad. Se distinguieron 6 tipos de UPF de acuerdo con sus capitales humano y social. El grupo 3 (G3) mostró un mejor equilibrio entre ambos por la participación familiar, destacándose entre los de mayor experiencia en el cultivo de maíces locales y por tener relaciones locales y de cooperación más sólidas. Se concluye que las UPF presentan  características que contribuyen o afectan la conservación de los maíces locales, como la continuidad generacional, el deterioro de los recursos naturales que sostienen el cultivo a través de la fusión de las prácticas tradicionales con las modernas y la dependencia de recursos externos.
Plantas medicinales usadas por los Tének en la Huasteca, México
Authors: Casanova-Pérez Cointa , Delgado-Caballero Carina Edith , Cruz-Bautista Patricia , Casanova-Pérez Lorena
Published: February 2022

Los Tének son un pueblo originario de México que practica aún la medicina tradicional, refle­jo de su interrelación con la naturaleza, su cos­movisión e identidad; sin embargo, este conocimiento se ha ido erosionado. El objetivo de la presente investigación fue determinar las dife­rentes especies de plantas medicinales usadas por los Tének para tratar síntomas asociados a enfermedades y lesiones. Se aplicó una encues­ta a 189 personas de 5 localidades de la Huasteca veracruzana, específicamente, del municipio de Tantoyuca, Veracruz, México. Además, se entrevistó a 19 médicos tradicionales. La información fue analizada a través de estadística descriptiva. Se detectaron 152 especies pertenecientes a 63 familias botánicas, de las cuales 10 concentran el 48 % de las especies identificadas. La forma biológica predominante fue la herbácea y 45 % de las especies eran silvestres. Las plantas medicinales mostraron tener una contribución importante en el sistema de salud de las localidades del área de estudio. Estas plantas son parte de su patrimonio biocultural, por lo que su germoplasma y su conocimiento tradicional asociado deben ser conservados ante condiciones como cambios del clima y del uso del suelo, la pobreza, y la migración de los más jóvenes; particularmente, porque este conocimiento tradicional ha sido heredado, básicamente, a través de la tradición oral.
Optimization of the Fuzzy Logic Method for Autism Spectrum Disorder Diagnosis
Authors: Wanti Linda Perdana , Lina Puspitasari
Published: February 2022

Diagnosis of autism spectrum disorder (ASD) can use a fuzzy inference system. The use of fuzzy logic method to obtain ASD diagnosis results according to experts based on the limits of factors/symptoms of the disease and all the rules obtained from experts. Recommendations for therapy and preventive actions can be given by experts after knowing the results of the diagnosis of ASD using the fuzzy logic method. This study serves to diagnose ASD by optimizing each degree of membership in the fuzzy logic method with the Mamdani method approach which is involved in the autism detection process involving 96 patient data. The Mamdani method itself can process an uncertain value from the user/patient into a definite value whose membership degree can be determined and adjusted to the conditions of the problem. Optimization was carried out on the degree of membership for all variables involved in the process of diagnosing ASD, namely social interaction, social communication and imagination and behavior patterns. The results of this study indicate a relatively small level of fuzzy calculation error with a precision value of 94.4%, a recall precision value of 65.4% and an error rate value of 3.05%. Calculation of accuracy shows a result of 90.59%.
Prediksi Harga Cryptocurrency Menggunakan Algoritma Long Short Term Memory (LSTM)
Authors: Moch Farryz Rizkilloh  , Sri Widiyanesti
Published: February 2022

Technological developments continue to encourage the creation of various innovations in almost all aspects of human life. One of the innovations that is becoming a worldwide phenomenon today is the presence of cryptocurrency as a digital currency that is able to replace the role of conventional currency as a means of payment. Currently, the number of cryptocurrency investors in Indonesia has reached 4.45 million people as of March 2021, an increase of 78% compared to the end of the previous year. Very volatile price movements make cryptocurrency investments considered speculative so the risks faced are also very high. The purpose of this study is to build a predictive model that is able to forecast prices on the cryptocurrency market. The algorithm used to build the prediction model is Long Short Term Memory (LSTM). LSTM is the development of the Recurrent Neural Network (RNN) algorithm to overcome problems in the RNN in managing data for a long period. LSTM is considered superior to other algorithms in managing time series data. The data in this study were taken from the Yahoo Finance website using the Pandas Datareader library through Google Collaboratory. The entire prediction model development process is carried out through Google Collaboratory tools. To improve the accuracy of the model, the Nadam optimization algorithm was used and three testing sessions were carried out with the number of Epochs of 1, 10, and 20 in each session. The final test results show that the best prediction performance occurs when testing the DOGE coin type with the number of Epoch 20 which gets an RMSE value of 0.0630.
Monitoring dan Kendali Tegangan Jaringan Listrik Fase-tiga melalui Smartphone
Authors: Goeritno Arief , Hendryan Febby
Published: February 2022

This paper describes the creation of a minimum system for monitoring and controlling the voltage on a three-phase electrical network. Making a minimum system based on the result of previous research that has been implemented in the forms of device assembly, programming, and performance measurement. The research objectives are (i) assembling the hardware and programming based on Arduino software version 1.8.10 and (ii) measuring the minimum system performance. The research method for achieving the objective of assembling a minimum system is carried out through integrated wiring as an effort to get the hardware achievement, while for programming is an effort to get the software achievement. The implementation of the research method for measuring the performance as an effort to get the achievements of hardware and software is carried out by giving the orders to activate the paths of each phase. The result of the assembly is the integration of the Arduino UNO R3 module, Ethernet Shield type of W5100, MikroTik RouterBoard, relay modules, and Android smartphone, while the results of the programming are compiling and uploading the syntax to the Arduino module and making applications in the .apk format for a smartphone. Performance measurements are carried out by activating conditions for the three phases of phase-R, phase-S, and/or phase-T. The conclusion can be obtained, that the manufacture of a minimum system is appropriate for the fulfillment with respect to the presence of an electronic device for monitoring and controlling the voltage on a three-phase electrical network.
ANALYSIS OF THE RELATIONSHIP BETWEEN SOCIAL INDICATORS AND MORTALITY FOR BREAST CANCER IN BRAZIL AND GOIÁS
Authors: Assunção Silvaleide Ataides , Miranda Ana Carla Moreira , Silva Laura Queiroz da , Terra Mariana Campos , Costa Guilherme Augusto da , Bunholli Anelize Maria , Rahal Rosemar Macedo Sousa
Published: February 2022

Objectives: Breast cancer is the most common cancer among the female population in the world. Socioeconomic and cultural factors are important, as underdeveloped countries have high mortality rates due to deficiencies in prevention and early detection. Thus, the objective is to verify whether there is a direct relationship between the number of deaths due to breast cancer and social indicators. Methodology: A descriptive study with the analysis of the secondary data on mortality from malignant breast neoplasms, relating them to social indicators of schooling, age, and color/race between the years 2010 and 2019 in the state of Goiás and in Brazil, was analyzed. The data were extracted from the Mortality Information System (SIM), ordered, and tabulated using Excel. Results: Socioeconomic factors, such as education, age group, race, and geographic region, were considered conditioning factors for inequalities for such neoplasia. Groups with lower socioeconomic status showed high mortality rates, either due to later diagnoses or due to greater difficulty in accessing appropriate treatments. In contrast, the population inserted in favored socioeconomic scenarios presented, at the same time, high mortality rates, not only in Goiás, but also in the Brazilian scenario in general. This situation resulted, above all, from the insertion of this female portion in the labor market and, consequently, from the acquisition of new habits and behaviors. Conclusion: Different variables related to socioeconomic and cultural conditions have a direct influence on the occurrence of breast cancer in women in the state of Goiás and also in Brazil. In summary, people in disadvantaged situations tend to have high mortality rates for not having access to financing health conditions, while the wealthier population also has high rates due to cultural factors and related to new habits and behaviors that are factors risk.
Investigating Different Age Groups’ Preferences and Purposes of Emoji Use
Authors: Memon Mahrukh , Ansari Sanaullah
Published: February 2022

The research explores how much do people of different age use the emoji in digital communication. It also studies the purposes behind the use. The study compares three different age groups. It aims to find if there are any significant differences among groups. Different aspects of emoji use are researched worldwide but there is less evidence from age perspective. There is very little research done in Pakistani context. So, this study adds to knowledge in the field in Pakistani context. A representative sample is chosen from intermediate, undergraduate and postgraduate students through quota sampling from colleges and universities from Hyderabad, Sindh in 2017. The participants fill the questionnaire and data is analyzed quantitatively. The study explores if emoji are effective for all generations or a specific generation. The study helps understand different attitudes towards use of emoji.
Improve customer satisfaction by quality functions deployment: Case in Indonesian SMEs
Authors: Tri Wahjoedi
Published: February 2022

This paper explores how the quality function deployment (QFD) is used to translate customer needs into technical parameters that will be controlled in the process and ultimately can produce products as customers expect. This research through field observations and brainstorming with representative employees to create house of quality and set recommendation actions. With strong support and commitment to complete actions, resulting in better product quality that shows a gradual shift in product quality from grade B to grade A means that operations are more reliable. Through QFD, it will be known what customers really want, which is the most important customer needs, what can be controlled in meeting customer needs so that customer needs can be met. This paper suggests several approaches and actions that can be of high value especially in the woodworking industries.
Content of 31 trace elements in thyroid malignant nodules and thyroid tissue adjacent to nodules investigated using neutron activation analysis and inductively coupled plasma mass spectrometry
Authors: Vladimir Zaichick
Published: February 2022

Thyroid malignant nodules (TMNs) are the most common endocrine cancer and the fifth most frequently occurring type of malignancies. Women are at particular risk for this thyroid disease The etiology and pathogenesis of TMNs must be considered as multifactorial. The present study was performed to clarify the role of some trace elements (TEs) in the etiology of these thyroid disorders. Thyroid tissue levels of silver (Ag), aluminum (Al), boron (B),, beryllium (Be), bismuth (Bi), cadmium (Cd), cerium (Ce), cobalt (Co), chromium (Cr), cesium (Cs), iron (Fe), gallium (Ga), mercury (Hg), lanthanum (La), lithium (Li), manganese (Mn), molybdenum (Mo), neodymium (Nd), nickel (Ni), lead (Pb), praseodymium (Pr), rubidium (Rb), antimony (Sb), scandium (Sc), selenium (Se), samarium (Sm), tin (Sn), thallium (Tl), uranium (U), yttrium (Y), and zinc (Zn) were prospectively evaluated in malignant tumor and thyroid tissue adjacent to tumor of 41 patients with TMNs. Measurements were performed using a combination of non-destructive instrumental neutron activation analysis and destructive method such as inductively coupled plasma mass spectrometry. Results of the study were additionally compared with previously obtained data for the same TEs in “normal” thyroid tissue. It was observed that main characteristics of TMNs in comparison with “normal” thyroid were significantly elevated levels of Ag, Al, B, Bi, Ce, Cr, Hg, Mn, Mo, Ni, Pb, Rb, Sm, and Tl. Furthermore, the TEs composition of thyroid tissue adjacent to tumor did not equal TEs contents of “normal” thyroid. Moreover, contents of such elements as Ag, Hg, and Se in adjacent tissue were higher than in tumor. Thus, from results obtained, it was possible to conclude that at least the excessive accumulation of Ag, Hg, and Se by thyroid tissue is likely to precede the TMNs origination and development. Elevated levels of Ag, Al, B, Bi, Ce, Cr, Hg, Mn, Mo, Ni, Pb, Rb, Sm, and Tl in nodular tissue could possibly be explored for differential diagnosis of benign and malignant thyroid nodules.
8 Fashion
Ancient Clothing
Authors: Acciarino Damiano
Published: February 2022

1 Introduction. – 2 Renaissance Works De Re Vestiaria. – 3 Dressing
the Ancients (i): Theatrical Costumes. – 3.1 Rome 1513 – 3.2 Vicenza 1585. – 3.3 A
Comparison. – 8.4 Dressing the Ancients (ii): the Gallery of Francis I at Fontainebleau.
Характеристики вторинного випромінювання тактичного безпілотного літального апарату у метровому, дециметровому і сантиметровому діапазонах хвиль
Authors: Сухаревський О.І. , Залевський Г.С. , Василець В.О. , Галкін Ю.О. , Горєлишев С.А. , Садовий К.В.
Published: February 2022

Розглядаються результати комп’ютерного моделювання характеристик вторинного випромінювання (ХВВ) моделі тактичного безпілотного літального апарату (БпЛА) у метровому, дециметровому та сантиметровому діапазонах хвиль. Аналізуються конструктивні особливості тактичного БпЛА як вторинного випромінювача у різних діапазонах хвиль. Описано цифрові моделі поверхонь елементів конструкції тактичного БпЛА. У залежності від електричних розмірів елементів конструкції БпЛА для моделювання використовувались різні електродинамічні методи. Наводиться їх стислий опис. Демонструються діаграми зворотного вторинного випромінювання (ДЗВВ) БпЛА та окремих металевих і діелектричних елементів його конструкції у трьох діапазонах хвиль, на двох ортогональних поляризаціях. Аналізується вклад елементів конструкції у сумарний розсіяний сигнал. Проводиться порівняння медіанних значень ефективної поверхні розсіювання (ЕПР) у азимутальних секторах для моделі тактичного БпЛА, крилатої ракети та винищувача у метровому, дециметровому та сантиметровому діапазонах хвиль. Наведені дані дозволяють оцінити можливості радіолокаційних станцій (РЛС) різних частотних діапазонів щодо виявлення і супроводження тактичних БпЛА.
Метод підвищення захисту інформації в неалгебраїчних декодерах Меггіта при несанкціонованому її перехопленні
Authors: Бітченко О.М. , Сайківська Л.Ф. , Цопа О.І. , Мерзлікін А.О.
Published: February 2022

Робота присвячена вдосконаленню структури неалгебраїчного декодера, що дозволяє підвищити захист інформації при несанкціонованому її перехопленні, шляхом введення додаткових синдромних регістрів зсуву зі зворотними зв'язками та блоку управління цими регістрами. У статті детально описано принцип роботи декодера, обумовлено введення синдромних регістрів зсуву зі зворотними зв'язками та показано, що така структура дозволяє за законом випадкових чисел постійно змінювати вид утворюючого полінома і тим самим суттєво зменшити вірогідність правильного декодування інформаційної посилки при її перехопленні.
Розробка моделі підготовчого етапу випробувань ОВТ: модель продуктивності випробувального підрозділу
Authors: Корнієнко І.В. , Корнієнко С.П. , Дмитрієв В.А. , Павленко А.Г. , Камак Д.О.
Published: February 2022

У статті розглянуті питання математичного моделювання процесів випробування, а саме забезпечення необхідної пропускної здатності випробувального підрозділу на підготовчому етапі випробувань. Здійснена деталізація раніше розглянутої загальної схеми процесів випробування, представленої у вигляді графічної моделі системи масового обслуговування. Відокремлені часові інтервали підготовчої стадії та стадії практичного випробування, які утворюють дві послідовні системи масового обслуговування. Виконана декомпозиція системи масового обслуговування підготовчої стадії до рівня окремого випробувального підрозділу, який в свою чергу представляється підсистемою системи масового обслуговування. Обґрунтовується використання значення математичного сподівання кількості фахівців одного підрозділу у випробувальній бригади для формування кількості каналів аналітичної моделі підсистеми масового обслуговування. На основі типових аналітичних моделей систем масового обслуговування формуються показники якості функціонування випробувального підрозділу. Здійснюється аналітичне моделювання підготовчого етапу на рівні випробувального підрозділу. Результати моделювання представлені у графічному вигляді, зроблені загальні підсумки та рекомендації.
Caracterización de la gestión y la calidad de espacios verdes públicos del frente fluvial del río Limay (Área Metropolitana de Neuquén, Argentina)
Authors: Lopez Micaela , Gentili Jorge
Published: February 2022

Los espacios verdes públicos (EVP) son elementos fundamentales de sostenibilidad urbana. No obstante, su gestión y mantenimiento requieren de elevada capacidad institucional. Puntualmente, en el Área Metropolitana de Neuquén (AMN) han surgido estrategias innovadoras en materia de EVP a través de la consolidación de frentes fluviales. El objetivo de este trabajo es caracterizar espacios verdes públicos del frente fluvial del río Limay en las ciudades de Neuquén y Plottier, para el establecimiento de relaciones entre la gestión local y la calidad física de los EVP. Para tal fin se aplicó un análisis multidimensional en torno a cuatro variables de interés: programas de renovación urbana costera vigentes; ordenamiento territorial ambiental (OTA); grado de complejidad urbana del EVP y su calidad. Se hallaron diferencias entre las localidades en relación con los programas urbanos vigentes y con el OTA de los espacios costeros. Estas divergencias se reflejan en el nivel de planificación interna de los EVP y su calidad física en función de las variables de análisis abordadas. A partir de las conclusiones del estudio, surgen algunos aspectos a considerar: i) la gestión de los EVP requiere una labor institucional multiescalar; ii) es positivo que la creación de EVP se enmarquen en proyectos urbanos que se consoliden en ordenanzas de OTA; iii) se precisan mecanismos que regulen el cumplimento de lo dispuesto en las ordenanzas vigentes; iv) el aprovechamiento de espacios costeros para recreación debe acompañarse de sensibilización y educación ambiental activa a sus usuarios.
A modest luminary of the Balkan studies
Authors:   Institute of Slavic Studies, Russian Academy of Sciences, Danchenko Svetlana I.
Published: February 2022

The essay traces the life and scientific career of Irina Stepanovna Dostyan (1920–2012), a prominent representative of the Russian historical science, who made a significant contribution to the formation and development of the Slavic and Balkan studies in the second half of the twentieth century. The author analyzes in detail the main works of I.S. Dostyan ― three monographs, parts in collective generalizing works, articles, and notes their significance, recognized in the USSR, Russia and other countries, in order to develop the most important problems of the history of the Balkan peoples and their relations with Russia at the end of the 18th ― first half of the 19th century, as well as to eliminate the so-called «unexplored facts" and debunk the myths that previously existed in science. Along with this, the essay touches upon the question of the role of I.S. Dostyan in the history of the Institute of Slavic Studies of the Russian Academy of Science, in which the historian worked for more than 60 years, since 1949.
The Danubian Principalities and Transylvania in the perception of Russian military observers (1848–1849) (based on the documents form the Russian State Military Historical Archive)
Authors:   Institute of Slavic Studies, Russian Academy of Sciences, Stykalin Alexander S.
Published: February 2022

Revolutionary events in many European countries in 1848 caused fears in St. Petersburg that further development could cause collapse of the multinational Austrian Empire and thus revive the so-called Polish question in the international arena, which would pose an immediate threat to the integrity of the Russian Empire. Evaluating the threat that had arisen, Nicholas I, after hesitation, decided to send troops to the Danubian Principalities, to annihilate revolutionary unrest, in accordance with the right to their patronage, which Russia possessed under the Adrianople Peace Treaty of 1829. In 1849 the corps of Russian troops stationed in Moldova and Wallachia took part in the campaign in Transylvania as well as the suppression of the Hungarian revolution. In this article, the events of that time are examined through the prism of the reports of Russian officers, participants of the military campaign. This source is valuable because it contains description of the situation in the Danubian Principalities and Transylvania, reflects interethnic contradictions in Transylvania. Active participation of Polish revolutionaries in the events made it possible to link more closely the situation in remote lands with the situation in Russia itself. The officers' reports demonstrate the allied relations between Russia and Turkey in the face of the revolutionary events of 1848 in Central Europe, their lose cooperation in "restoring order" in Wallachia; as yet little augured a new, very early aggravation of the relations between the two powers, which eventually led to the Crimean War in 1853.
The monument to Alexander II in Sofia — history of its erection
Authors:   Sofia University, Georgieva Tina N.
Published: February 2022

The article reveals details of the construction of the monument to Alexander II in the center of Sofia. It examines the activity of a special Committee which expressed the idea to erect a monument in honour of the Russian emperor, and which organised its practical realisation: collecting money, development of the terms of the architect competition and holding one. Participation of the Bulgarian authorities and the role of the Bulgarian prince Ferdinand in the implementation of the public initiative is also considered.
The place of service is Sarajevo. A.S. Ionin's first diplomatic experience
Authors:   Institute of Slavic Studies, Russian Academy of Sciences, Melchakova Ksenia V.
Published: February 2022

Based on the previously unpublished archival materials, the essay reconstructs history of the stay of the Russian diplomat Alexander S. Ionin (1837–1900) in the Ottoman provinces of Bosnia and Herzegovina. In 1857, for the first time in history, the Russian consulate was opened in the principal city of the Bosnian Pashalyk. A. Ionin was assigned to Sarajevo as a secretary and dragoman in this consulate. Here he worked under the leadership of A. Hilferding, and then E. Shchulepnikov until 1860. Ionin witnessed the uprisings in Herzegovina, worked hard on the problem of opening a Russian consulate in Mostar, and for some time unofficially served as a consul in Sarajevo. This was the first diplomatic experience of a man who eventually spent about 30 years of his life in the Balkans and was an active participant in many significant events in the history of the region.
ussian policy in the Balkans on the eve of World War I: key aspects of the issue
Authors:   Institute of Slavic Studies, Russian Academy of Sciences, Iskenderov Petr A.
Published: February 2022

The article is devoted to the analysis of Russia's policy in the Balkans on the eve of World War I. The attention is mainly paid to the debatable aspects of this problem. The author identifies key factors that had an impact on the formation and implementation of the Balkan policy of Russia in the period under review. The research is based on unpublished archival documents.
The Balkan version of the regime of personal power (Todor Zhivkov and Nicolae Ceausescu)
Authors:   Institute of Slavic Studies, Russian Academy of Sciences, Volokitina Tatiana V.
Published: February 2022

The article analyses the commonalities and features of the so-called «Zhivkovism» and «Ceaushism», i.e. the Balkan version of the regimes of personal power. An attempt is made to characterise the role of «the Soviet factor» in the activity and fate of the two dictators ― Todor Zhivkov and Nicolae Ceausescu.
First records ofVanessa atalanta(Linnaeus, 1758) in Tajikistan (Lepidoptera: Nymphalidae)
Authors: Davlatov Abdulaziz
Published: February 2022

Vanessa atalanta(Linnaeus, 1758) is reported from Tajikistan for the first time. The distribution of this species in Central Asia is discussed.
Effects of Rhodiola semenowii extract on hematological parameters in experimental hypothyreosis
Authors: Korbozova N.K. , Kobylina T.N. , Kudrina N.O. , Terletskaya N.V. , Shokan A.K.
Published: February 2022

Thyroid pathology has a leading position in clinical endocrinology. Diseases of the thyroid gland in terms of prevalence are comparable with diabetes mellitus, and far ahead of other endocrine disorders. Current treatment approaches of hypothyroidism are rarely based on the pathogenesis, and are reduced to hormone replacement therapy. The purpose of this study is to determine the general hematological parameters after correction of experimental hypothyroidism with an extract of the root of the plant R. semenowiiboth alone and in combination with potassium iodide. As a result of the study, we found that in the experimental treatment of hypothyroidism, the extract of the root of R. semenowiiB. with a predominant content of rhodioflavonoside has a pronounced therapeutic effect, expressed in the normalization of the level of pituitary and thyroid hormones. The obtained results indicate the absence of toxic and damaging effects such as activation and inhibition of hematopoiesis after enteral administration of the root extract of R. semenowii.