bluuebunny/crossref_metadata_2025 huggingface dataset:
Network-Based Modeling of Lean Implementation Strategies and Planning in Prefabricated Construction
Authors: Dang Pei , Geng Linna , Niu Zhanwen , Jiang Shan , Sun Chao
Published: October 2024

Prefabricated construction (PC) is increasingly promoted in the construction sector for its potential benefits, including reduced resource assumption and improved quality. Accordingly, Lean methods are popularly applied to PC projects for optimizing operational processes and enhancing their performance in line with strategic objectives. A key factor in effectively implementing Lean to improve strategic control is developing specific strategies and planning that consider their complex interactions. Thus, this paper aims to propose a quantitative network-based model by integrating Interpretive Structural Modeling (ISM) and Matrix Impact Cross-Reference Multiplication Applied to a Classification (MICMAC) under complex network theory to develop a Lean implementation framework for effective strategy formulation. Specifically, 17 Lean implementation strategies for PC in the context of the Chinese prefabrication industry were identified via an extensive literature review and expert interviews. Then, ISM-MICMAC quantitatively identifies the direct and indirect relationships among strategies, while subsequent analysis of Topological Structure Weight (TSW) and Structural Degree Weight (SDW), as complex network parameters, is used to evaluate the importance of each strategy. The findings show that the strategic planning for Lean implementation in PC consists of four levels, i.e., foundation, organizational, technical, and control. Selecting appropriate Lean tools and technologies is crucial for PC implementation, which must be built on a top-level management team and foster a Lean culture. Moreover, it involves building a standardized system of processes and activities, enhancing both internal and external collaboration, and continuously improving processes in response to changes. On one hand, this in-depth network-based analysis offers practical insights for PC stakeholders, particularly in China, on Lean implementation in line with PC performance and strategic control and objectives. On the other hand, the network-based model can be future-implemented globally. Additionally, this study expands the current body of knowledge on Lean in PC by exploring the interrelationships of Lean implementation strategies.
Study on the Susceptibility of Steel Arches with Letting Pressure Nodes Based on Incremental Dynamic Analysis
Authors: Deng Kaiying , Zhang Qingwen , Pu Xuan , Ma Rongkang , Kou Junwei
Published: October 2024

When soft rock tunnels pass through fractured fault zones, they are particularly susceptible to extrusion and large-scale deformations, especially during seismic events. To address these challenges, this study introduces an innovative yield-support steel arch design featuring a circumferential letting pressure node at its core. This design delivers incremental support resistance within the deformation zone and a susceptibility curve is applied to evaluate the damage probability of the steel arch with a letting pressure node under seismic loading conditions. Measurements of the surrounding rock pressure and structural forces on the steel arch with the letting pressure node were conducted at the Baoshan Jewel Mountain Tunnel in China. The field experiment results revealed a 23% reduction in the surrounding rock pressure and an 11% decrease in the internal forces of the support structure. These findings demonstrate the successful application of the letting pressure node-supported steel arch in mitigating large deformations in soft rock environments. Additionally, using finite element software ANSYS 2022, a seismic time-history analysis was conducted, employing the relative deformation rate of the letting pressure node steel arch as the damage index and the peak ground acceleration (PGA) as the strength parameter to generate the incremental dynamic analysis (IDA) curve. According to the susceptibility curve derived from the incremental dynamic analysis, at the design ground motion level of 8 degrees, the letting pressure node steel arch has a 94% probability of exceeding its normal service life limit and experiencing damage. The findings of this study offer a novel approach to addressing large deformations in soft rock tunnels. The proposed susceptibility curves for steel arches with letting pressure nodes provide a robust foundation for predicting the damage probability of yielding support structures under seismic conditions.
Role of Imaging in Screening for Hepatocellular Carcinoma
Authors: Kazi Irfan A. , Jahagirdar Vinay , Kabir Bareen W. , Syed Almaan K. , Kabir Asad W. , Perisetti Abhilash
Published: October 2024

Primary liver cancer is among the most common cancers globally. It is the sixth-most common malignancy encountered and the third-most common cause of cancer-related death. Hepatocellular carcinoma (HCC) is the most common primary liver malignancy, accounting for about 90% of primary liver cancers. The majority of HCCs occur in patients with underlying cirrhosis, which results from chronic liver diseases such as fatty liver, hepatitis B and hepatitis C infections, and chronic alcohol use, which are the leading causes. The obesity pandemic has led to an increased prevalence of nonalcoholic fatty liver disease (NAFLD), which leads to nonalcoholic steatohepatitis and could progress to cirrhosis. As HCC is among the most common cancers and occurs in the setting of chronic liver disease in most patients, screening the population at risk could help in early diagnosis and management, leading to improved survival. Screening for HCC is performed using biochemical marker testing such as α-fetoprotein (AFP) and cross-sectional imaging. It is critical to emphasize that HCC could potentially occur in patients without cirrhosis (non-cirrhotic HCC), which can account for almost 20% of all HCCs. The lack of cirrhosis can cause a delay in surveillance, which could potentially lead to diagnosis at a later stage, worsening the prognosis for such patients. In this article, we discuss the diagnosis of cirrhosis in at-risk populations with details on the different modalities available for screening HCC in patients with cirrhosis, emphasizing the role of abdominal ultrasounds, the primary imaging modality in HCC screening.
A Clinico-Genetic Score Incorporating Disease-Free Intervals and Chromosome 8q Copy Numbers: A Novel Prognostic Marker for Recurrence and Survival Following Liver Resection in Patients with Liver Metastases of Uveal Melanoma
Authors: Mariani Pascale , Pierron Gaëlle , Ait Rais Khadija , Bouhadiba Toufik , Rodrigues Manuel , Malaise Denis , Lumbroso-Le Rouic Livia , Barnhill Raymond , Stern Marc-Henri , Servois Vincent , Ramtohul Toulsie
Published: October 2024

Surgical treatment of liver metastases of uveal melanoma (LMUM) could be proposed for selected patients. This retrospective study examined the prognostic significance of the genetic profiles of liver metastases after LMUM resection. A total of 86 patients treated with resection for LMUM, who underwent genetic analysis of liver metastasis, were included. A multivariable Cox model identified the independent predictors of recurrence-free survival (RFS) and overall survival (OS). The disease-free interval (DFI) and a chromosome 8q surgain (>3 copies) were independent predictors and categorized patients into three risk groups with distinct postoperative prognoses. For the low-, intermediate-, and high-risk scores of recurrence, the median RFS values were 15 months (95% CI: 10–22), 6 months (95% CI: 4–11), and 4 months (95% CI: 2–7), and the median OS values were 86 months (95% CI: 55-NR), 25 months (95% CI: 17–48), and 19 months (95% CI: 12–22), respectively. The predictive accuracy of this scoring system was demonstrated by a mean area under the curve (AUC(t)) of 0.77 (95% CI: 0.65–0.90) for RFS and 0.81 (95% CI: 0.70–0.92) for OS. This novel score, based on a DFI of ≤24 months combined with a chromosome 8q surgain, identifies patients at a high risk of early recurrence and could help clinicians to propose perioperative treatment.
Advances in Cancer Therapy: A Comprehensive Review of CDK and EGFR Inhibitors
Authors: Hawash Mohammed
Published: October 2024

Protein kinases have essential responsibilities in controlling several cellular processes, and their abnormal regulation is strongly related to the development of cancer. The implementation of protein kinase inhibitors has significantly transformed cancer therapy by modifying treatment strategies. These inhibitors have received substantial FDA clearance in recent decades. Protein kinases have emerged as primary objectives for therapeutic interventions, particularly in the context of cancer treatment. At present, 69 therapeutics have been approved by the FDA that target approximately 24 protein kinases, which are specifically prescribed for the treatment of neoplastic illnesses. These novel agents specifically inhibit certain protein kinases, such as receptor protein-tyrosine kinases, protein-serine/threonine kinases, dual-specificity kinases, nonreceptor protein-tyrosine kinases, and receptor protein-tyrosine kinases. This review presents a comprehensive overview of novel targets of kinase inhibitors, with a specific focus on cyclin-dependent kinases (CDKs) and epidermal growth factor receptor (EGFR). The majority of the reviewed studies commenced with an assessment of cancer cell lines and concluded with a comprehensive biological evaluation of individual kinase targets. The reviewed articles provide detailed information on the structural features of potent anticancer agents and their specific activity, which refers to their ability to selectively inhibit cancer-promoting kinases including CDKs and EGFR. Additionally, the latest FDA-approved anticancer agents targeting these enzymes were highlighted accordingly.
Modulation of Autophagy–Lysosome Axis by African Swine Fever Virus and Its Encoded Protein pEP153R
Authors: Bai Si-Yu , Weng Wenlian , Wang Hua , Cui Zhiying , Wu Jiajun , Qu Yajin , Hao Yuxin , Gao Peng , Zhang Yongning , Zhou Lei , Ge Xinna , Guo Xin , Han Jun , Yang Hanchun
Published: October 2024

The autophagy–lysosome axis is an evolutionarily conserved intracellular degradation pathway which constitutes an important component of host innate immunity against microbial infections. Here, we show that African swine fever virus (ASFV), one of most devastating pathogens to the worldwide swine industry, can reshape the autophagy–lysosome axis by recruiting the critical lysosome membrane proteins (LAMP1 and LAMP2) to viral factories while inhibiting autophagic induction in macrophages. The screening of viral membrane proteins led to the identification of several ASFV membrane proteins, exemplified by viral protein pEP153R, that could significantly alter the subcellular localization of LAMP1/2 when expressed alone in transfected cells. Further analysis showed that pEP153R was also a component of viral factories and could induce endoplasmic reticulum (ER) retention of LAMP1/2, leading to the inhibition of the fusion of autophagosomes with lysosomes. Interestingly, the ASFV mutant lacking EP153R could still actively recruit LAMP into viral factories (VFs) and inhibit autophagic flux, indicating the existence of a functional redundancy of other viral proteins in the absence of pEP153R and highlighting the complexity of ASFV replication biology. Taken together, our results reveal novel information about the interplay of ASFV with the autophagy–lysosome axis and a previously unrecognized function of ASFV protein pEP153R in regulating the cellular autophagic process.
The First Comprehensive Evaluation of Immuno-Inflammatory Markers for Prognosis in Esophageal Cancer Patients: A South Asian Perspective
Authors: Qureshi Sajida , Abbasi Waqas Ahmad , Jalil Hira Abdul , Mughal Saba , Quraishy Muhammad Saeed
Published: October 2024

Background: Esophageal cancer (EC) remains a significant health challenge in South Asia, with poor prognosis despite advancements in diagnostics and treatment. Identifying and validating prognostic factors is essential for improving patient outcomes. Methods: A prospective study was conducted with 146 biopsy-confirmed EC patients at the Dr. Ruth K.M. Pfau Civil Hospital, Karachi, Pakistan. Clinical and laboratory data were collected and analyzed using descriptive statistics, receiver operating characteristic (ROC) analysis, and the Chi-square test. Survival outcomes were assessed using Kaplan–Meier curves, log-rank tests, and Cox proportional hazard models for univariate and multivariate regression analyses, with statistical significance set at p ≤ 0.05. Results: Bivariate analysis showed significant associations of the neutrophil lymphocyte ratio (NLR) (p = 0.017), C-reactive protein to albumin ratio (CAR) (p = 0.033), red cell distribution width to platelet ratio (RPR) (p = 0.020), and systemic immune-Inflammation index (SII) (p = 0.009) with patient survival. Univariate analysis identified tumor length >10 cm (p = 0.016), T4 stage (p = 0.015), metastasis (p < 0.001), surgery not performed (p < 0.001), and SII (p = 0.022) as significant factors for survival, with higher SII linked to poorer overall survival (p = 0.020). Interestingly, in the multivariate model, only metastasis (p < 0.001) and surgery not performed (p = 0.011) remained significant. Conclusions: Immuno-inflammatory markers may be less pertinent prognostic factors for EC in the South Asian population.
Investigation of the Influence of the Oxygen Flow Rate on the Mechanical, Structural and Operational Properties of 86WC-10Co-4Cr Coatings, as Determined Using the High-Velocity Oxyfuel Spraying Method
Authors: Rakhadilov Bauyrzhan , Muktanova Nazerke , Seitkhanova Ainur , Kakimzhanov Dauir , Dautbekov Merkhat
Published: October 2024

The structural-phase composition and tribological and performance properties of coatings based on an 86WC-10Co-4Cr composition obtained by the HVOF method at varying (150 L/min, 170 L/min, 190 L/min) oxygen flow rates were studied. The results showed that the coefficient of friction of coatings in gear oil remained almost unchanged with the variation in oxygen flow rate. However, microhardness increased significantly with an increasing oxygen flow rate, reaching a maximum at 190 L/min. An increasing oxygen flow rate was also accompanied by an increase in roughness and coating thickness, with a decrease in porosity, particularly notable at 190 L/min. Adhesion strength reached the maximum values for the A2 and A3 coatings under high loads. The phase composition of the coatings included WC, W2C and CoO phases irrespective of the oxygen flow rate, and their microstructure was characterized by a more homogeneous and dense structure. Thus, this study confirmed that the optimal oxygen flow rate for achieving an improved performance and tribological characteristics of 86WC-10Co-4Cr coatings is 190 L/min.
Special Issue “Synthesis, Characterization and Performance Enhancement of Electrode and Biomaterial Coatings”
Authors: Liu Chenyu , Sun Qing , Wang Shang
Published: October 2024

Functional materials are extensively employed across diverse domains, including energy storage systems [...]
Antifungal Ability of Novel Silane on Titanium Implant Surface
Authors: Liu Xiaotian , Chen Shuyang , Ding Hao , Tsoi James Kit Hon
Published: October 2024

Titanium and its alloys are commonly used in dentistry for implants due to their strength, lightweight nature, durability, corrosion resistance, and biocompatibility. These implants can osseointegrate after surface treatments such as SLA, plasma-spray, and nanotubes, providing a stable foundation for prostheses. However, Candida albicans, an opportunistic fungal pathogen, can threaten the success of titanium dental implants, causing oral infections in vulnerable individuals. A dual novel silane blend of 3-acryloxypropyltrimethoxysilane (ACPS) and bis-1,2-(triethoxysilyl)ethane (BTSE) has been shown to improve the shear bond strength in resin cement bonds with titanium and ceramics. This study evaluated the effects of Candida albicans colonization on blended silane-coated SLA-Ti surfaces compared to non-coated SLA-Ti (positive control) and flat titanium (negative control). Candida albicans biofilms were cultured on all surfaces, and it was found that silane-coated SLA-Ti had significantly lower CFU counts than non-coated SLA-Ti. However, no significant differences were observed in the RT-PCR results. In conclusion, a combination of 1.0 vol% ACPS and 0.3 vol% BTSE shows promise as a silane coupling agent with potential antifungal properties for inhibiting Candida albicans proliferation.
3D Hierarchical Composites of Hydrotalcite-Coated Carbon Microspheres as Catalysts in Baeyer–Villiger Oxidation Reactions
Authors: Estrada-Ruiz Marta , Cosano Daniel , Esquivel Dolores , Romero-Salguero Francisco J. , Ruiz José Rafael
Published: October 2024

The use of heterogeneous catalysts is fundamental in the search for sustainable chemical processes. Research on hierarchical materials is a growing field aimed at optimizing the synthesis of catalysts. In this work, layered materials with metals of different cationic ratios and three-dimensional hierarchical structures have been synthesized in a simple and easy way using carbon spheres as support. All materials were characterized with various techniques such as XRF, elemental analysis XRD, FT-IR, SEM, and TEM to study their composition and structure. Finally, these materials were used in the Baeyer–Villiger reaction, which was carried out under optimized conditions. The results showed that the metal ratio was an important factor in the coating process, affecting the catalytic capacity of the materials.
Report from the 25th Annual Western Canadian Gastrointestinal Cancer Consensus Conference on Gastric and Gastroesophageal Cancers, Winnipeg, Manitoba, 26–27 October 2023
Authors: Wong Ralph , Anderson Brady , Bashir Bashir , Bateman Justin , Chalchal Haji , Davies Janine , Dehmoobed Anahita , Geller Georgia , Ghose Abhijit , Gill Sharlene , Gordon Vallerie , Green Susan , Hebbard Pamela , Iqbal Mussawar , Ji Shuying , Karachiwala Hatim , Kidane Biniam , Kim Christina , Kosyachkova Ekaterina , Krahn Marianne , Krishnan Tharani , Kristjanson Mark , Lee Sangjune , Lee-Ying Richard , Lelond Stephanie , Liu Hong-Wei , Meyers Daniel , Mulder Karen , Paul James , Planincic Elvira
Published: October 2024

The 25th Annual Western Canadian Gastrointestinal Cancer Consensus Conference (WCGCCC) was held in Winnipeg, Manitoba, on 26–27 October 2023. The WCGCCC is an interactive multidisciplinary conference that was attended by healthcare professionals from across Western Canada (British Columbia, Alberta, and Manitoba) who are involved in the care of patients with gastrointestinal cancer. Surgical, medical, and radiation oncologists; pathologists; oncology nurses; pharmacists; and a family physician in oncology (FPO) participated in presentation and discussion sessions for the purpose of developing the recommendations presented here. This consensus statement addresses current issues in the management of gastroesophageal cancers.
Disseminated Histoplasmosis Diagnosed in an Immunocompetent Patient from a Non-Endemic Area: Neglected or Emerging Disease?
Authors: Ciortescu Irina , Nemteanu Roxana , Chiriac Ilinca Maria , Zaharia Silvia , Coseru Alexandru Ionut , Dumitrascu Diana Lacramioara , Vasilescu Alin , Danciu Mihai , Ochisor Catalina , Plesa Alina
Published: October 2024

Histoplasma capsulatum (H. capsulatum) is considered to be one of the most extensively spread dysmorphic fungi worldwide. Histoplasmosis primarily impacts patients with weakened immune systems and can result in a diverse range of clinical manifestations. In immunocompetent patients, the disease may manifest as a self-limiting or asymptomatic infection; however, in immunocompromised individuals, it can occur as a debilitating, disseminated disease. Diagnosing histoplasmosis may be challenging. A medical professional that specializes in treating endemic fungal illnesses is better able to assist with an accurate and timely diagnosis since they have a deeper grasp of these illnesses. Consequently, the process of diagnosing histoplasmosis might be difficult for less experienced physicians. The case presented is an example of the myriad faces that histoplasmosis can take on, mimicking other common infectious or malignant conditions, leading to extensive work-up and invasive procedures in establishing the diagnosis of this otherwise benign condition. We hereby report the case of disseminated histoplasmosis in a young immunocompetent female patient.
Predicting the Malignancy Grade of Soft Tissue Sarcomas on MRI Using Conventional Image Reading and Radiomics
Authors: Schmitz Fabian , Voigtländer Hendrik , Jang Hyungseok , Schlemmer Heinz-Peter , Kauczor Hans-Ulrich , Sedaghat Sam
Published: October 2024

Objectives: This study aims to investigate MRI features predicting the grade of STS malignancy using conventional image reading and radiomics. Methods: Pretherapeutic imaging data regarding size, tissue heterogeneity, peritumoral changes, necrosis, hemorrhage, and cystic degeneration were evaluated in conventional image reading. Furthermore, the tumors’ apparent diffusion coefficient (ADC) values and radiomics features were extracted and analyzed. A random forest machine learning algorithm was trained and evaluated based on the extracted features. Results: A total of 139 STS cases were included in this study. The mean tumor ADC and the ratio between tumor ADC to healthy muscle ADC were significantly lower in high-grade tumors (p = 0.001 and 0.005, respectively). Peritumoral edema (p < 0.001) and peritumoral contrast enhancement (p < 0.001) were significantly more extensive in high-grade tumors. Tumor heterogeneity was significantly increased in high-grade sarcomas, particularly in T2w- and contrast-enhanced sequences using conventional image reading (p < 0.001) as well as in the radiomics analysis (p < 0.001). Our trained random forest machine learning model predicted high-grade status with an area under the curve (AUC) of 0.97 and an F1 score of 0.93. Biopsy-underestimated tumors exhibited differences in tumor heterogeneity and peritumoral changes. Conclusions: Tumor heterogeneity is a key characteristic of high-grade STSs, which is discernible through conventional imaging reading and radiomics analysis. Higher STS grades are also associated with low ADC values, peritumoral edema, and peritumoral contrast enhancement.
Internal Quality Controls in the Medical Laboratory: A Narrative Review of the Basic Principles of an Appropriate Quality Control Plan
Authors: Gruber Lorenz , Hausch Artur , Mueller Thomas
Published: October 2024

To ensure the quality of their analyses, medical laboratories carry out internal quality control (IQC) on a daily basis. IQC involves control samples with known target values for all parameters used by a laboratory in clinical practice. The use of IQC enables the laboratory to monitor the accuracy and precision of laboratory results. The use of appropriate IQC strategies has been accepted in medical laboratories for decades, and IQC has been included in international recommendations and guidelines. The term “IQC strategy” (also termed a quality control plan) refers to the types of IQC materials to be measured, the frequency of IQC events, the number of concentration levels in each IQC event, and the IQC rules to be used. A scientifically sound IQC strategy must follow two principles, namely, (1) statistical follow-up on the IQC results generated in the laboratory by means of Levey–Jennings control charts and Westgard rules (i.e., quality control by means of statistical procedures) and (2) the determination of limits on the basis of medical considerations and the definition of analytical goals (quality control on the basis of medical relevance). In this narrative review, we describe the fundamental principles of an adequate IQC strategy for laboratorians and nonlaboratorians.
Establishing Neuron-Specific Enolase Reference Intervals: A Comparative Analysis of Partitioned Approach- and Gender-Based Continuous Age- and Season-Related Models
Authors: Zhao Haibin , Zhu Dong , Zhang Miaomiao , Wang Tengjiao , Han Ning , Ge Tinglei , Ma Xiaoming , Wu Anxin , Li Runqing , Zhao Xiuying
Published: October 2024

Background/Objectives: Static reference intervals (RIs) fail to capture the dynamic changes in bioanalytes. This study aimed to develop gender-based continuous age- and season-related RIs for neuron-specific enolase (NSE) using real-world data and to compare them with partitioned RIs. Methods: The NSE results from 4097 individuals were included after rigorous screening. Partitioned RIs were determined using the Hoffmann method. Generalized additive models for location, scale and shape (GAMLSS) were selected to develop continuous RIs. Results: The partitioned RIs are as follows: <16.4 µg/L for males aged ≥19 years; <14.47 µg/L for females aged 19–49 years; and <17.25 µg/L for females aged ≥50 years. For continuous RIs, NSE levels in males remain stable with age, while in females, NSE levels evidently increase around the age of 50. Although less impactful than age, seasonal changes still affect NSE levels. Dynamic changes and continuous RIs for NSE are visualized in this study. Conclusions: We developed gender-based continuous age- and season-integrated RIs for NSE in North China, highlighting the variation in NSE levels in females with age and season. Compared to static RIs, continuous RIs are more responsive to NSE, potentially enhancing the precision and individualization of health assessments.
Differentiating between Lymphoma and Metastasis Presenting as Solid Cerebellar Mass Lacking Necrosis
Authors: Park Gye Ryeong , Baek Byung Hyun , Kim Seul Kee , Yoon Woong , Park Ilwoo , Lee Yun Young , Jung Tae-Young
Published: October 2024

Objectives: This study aimed to identify radiologic features that differentiate lymphoma from metastasis manifesting as a solid enhancing mass lacking necrosis in the cerebellum. Methods: Pathologically confirmed 24 primary central nervous system lymphoma (PCNSL) and 32 metastasis patients with solid enhancing cerebellar masses without necrotic or hemorrhagic components were retrospectively analyzed. We evaluated the imaging characteristics using contrast-enhanced magnetic resonance imaging (MRI). The serrate sign was defined as a tumor spreading along white matter with branch-like enhancement or outward spikes. Results: The serrate sign was exclusively identified in the PCNSL group, showing a significant difference compared to the metastasis group (75.0% vs. 0%, p < 0.001). Homogeneous enhancement occurred more frequently in PCNSL than in metastasis (91.7% vs. 21.9%, p < 0.001). Conversely, bulging contour (62.5% vs. 4.2%, p < 0.001) and surface involvement (71.9% vs. 29.2%, p = 0.003) were more prevalent in metastasis than PCNSL. For predicting PCNSL, the serrate sign demonstrated 75.0% sensitivity, 100% specificity, 100% positive predictive value, 84.2% negative predictive value, and 89.3% accuracy. Conclusions: This study found that the serrate sign and homogeneous enhancement are reliable MRI features for differentiating cerebellar PCNSL from metastasis, whereas a bulging contour and surface involvement suggest metastasis. The serrate sign demonstrated diagnostic significance in differentiating PCNSL from metastasis.
Superscan Pattern on Bone Scintigraphy: A Comprehensive Review
Authors: Askari Emran , Shakeri Sara , Roustaei Hessamoddin , Fotouhi Maryam , Sadeghi Ramin , Harsini Sara , Vali Reza
Published: October 2024

Background/Objectives: The superscan pattern is a characteristic finding on bone scintigraphy, associated with a variety of metabolic bone diseases, malignancies, and other conditions. This pattern is characterized by a diffuse and intense uptake of radiotracer throughout the entire skeleton. Despite being a relatively rare finding, the superscan pattern can have significant clinical implications. Methods: This comprehensive review summarizes the available literature on the superscan pattern, focusing on its pathophysiology, clinical significance, and differential diagnoses. Relevant studies and case reports were analyzed to outline the diagnostic challenges associated with the interpretation of bone scintigraphy featuring the superscan pattern. Results: The literature highlights the clinical significance of the superscan pattern in various metabolic and oncologic conditions. Misinterpretation of this pattern can lead to diagnostic challenges, especially in distinguishing it from other pathologic conditions. Differential diagnosis remains crucial in the accurate interpretation and subsequent management of patients with this finding. Conclusions: This review provides a comprehensive overview of the superscan pattern on bone scintigraphy, aiming to assist clinicians in recognizing and managing this rare yet clinically important finding.
Return-to-Play Post-Myocarditis for Athletes: To Play or Not to Play?
Authors: Yamagata Kentaro , Malhotra Aneil
Published: October 2024

Myocarditis is a condition marked by inflammation of the heart muscle, which can lead to serious outcomes such as sudden cardiac death (SCD) and life-threatening arrhythmias. While myocarditis can affect any population, athletes, especially those engaged in high-intensity training, are at increased risk due to factors such as reduced immunity and increased exposure to pathogens. This review examines the clinical presentation, current guidelines, diagnostic challenges, and the significance of cardiac magnetic resonance imaging (CMR) in detecting myocardial inflammation and scarring. Current guidelines recommend a period of exercise restriction followed by thorough reassessment before athletes can return-to-play (RTP). However, there are several knowledge gaps, including the implications of persistent late gadolinium enhancement (LGE) on CMR and the optimal duration of exercise restriction. Additionally, the psychological impact of myocarditis on athletes highlights the importance of incorporating mental health support in the recovery process. A shared decision-making approach should be encouraged in RTP, considering the athlete’s overall health, personal preferences, and the potential risks of resuming competitive sports. We have proposed an algorithm for RTP in athletes following myocarditis, incorporating CMR. Future research is warranted to refine RTP protocols and improve risk stratification, particularly through longitudinal studies that examine recovery and outcomes in athletes.
Proposal of a New Therapeutic Classification in Gingival Smiles Focused on Treatment with Semi-Permanent Infiltrations
Authors: Angulo-Manzaneque Gema , Baus-Domínguez María , Ruiz-de-León Gonzalo , Serrera-Figallo María-Ángeles , Aguilera Fátima S. , Torres-Lagares Daniel
Published: October 2024

A gummy smile, defined as excessive gingival exposure while smiling, is an esthetic and functional condition affecting an individual’s quality of life. Despite its prevalence and impact, the classification and treatment of the gummy smile remain challenging in clinical practice. The problem lies in (1) the fact that the etiology of this pathology is multifactorial, and these factors sometimes go unnoticed, (2) the lack of consensus on the classification criteria, which, together, create (3) challenges in designing an optimal treatment plan for each patient. This article reviews the etiologic factors of this condition as the main basis for understanding the existing classifications of the gummy smile. It highlights the importance of muscle dynamics in the genesis and treatment of this clinical condition. We present a new, treatment-oriented classification that integrates the muscle hyperactivity present within the classification criteria and explore the implication of this interaction in the design of effective treatments. The ultimate goal of this present work is to improve the clinical understanding of the gingival smile and offer more personalized treatment strategies, through a more complete classification.
Networked Control of a Small Drone Resilient to Cyber Attacks
Authors: Ștefan Octavian , Codrean Alexandru
Published: October 2024

With increasing advances in networked systems and networked control systems in everyday life, the problem of cybersecurity becomes crucial. Moreover, in some applications like small UAVs, the safety and integrity of the system and its surroundings are highly susceptible to cyberattacks. In this context, the current paper proposes a resilient networked control approach. The control structure is split into an inner and an outer loop. The outer position control loop uses measurements from motion cameras connected to a remote computer, while the commands are sent through the network. We consider the resilience problem for two types of cyberattacks: denial of service (DoS), emulated as an increase in the network transmission delay, and man in the middle (MitM), emulated as additive input disturbances. The mitigation for the DoS attack is performed through the help of a reference governor (RG), which uses the delay estimates and the system’s model to predict future safety violations and adapts the reference accordingly. The MitM attack is mitigated by an unknown input disturbance observer (UIDO) together with a RG. Experimental results on a Parrot Mambo drone show that both types of attacks are rejected successfully, ensuring a safe and stable flight.
Is Zagreb Green Enough? Influence of Urban Green Spaces on Mitigation of Urban Heat Island: A Satellite-Based Study
Authors: Krsnik Goran
Published: October 2024

The urban heat island phenomenon is a climatic condition in which urbanized areas exhibit higher temperature values than their natural surroundings. This occurs due to an unbalanced energy budget caused by the extensive use of synthetic materials. In such a scenario, urban green areas act as stressors to mitigate the intensity of the urban heat island and improve urban well-being. This study analyzes the spatial-temporal characteristics of the urban heat island in Zagreb, Croatia, aiming to examine the role of different types of green infrastructure in mitigating elevated temperature values and facilitating the definition of greener planning strategies. To achieve this, a multitemporal remote sensing- and NDVI-based analysis was conducted for the time series 1984–2014. An urban heat island intensity map was obtained for the selected 30-year period, along with thermal graphs registering land surface temperature values among different city districts. The results reveal significant heterogeneity, displaying variable behavior dependent on the city district. The role of Zagreb’s urban green areas in urban heat island mitigation is evident but largely dependent on urban morphology, construction types, and periods. Urban forests and urban parks play the most significant role in temperature reduction, followed by residential building neighborhoods and extensive neighborhoods consisting of familiar houses with gardens. Continuously built areas, such as the city center and industrial zones, are less prone to registering lower intensity values. Additionally, multitemporal intensity variations based on land use changes are registered in several districts.
Beyond the Language: Arabic Language Textbooks in Arab–Palestinian Society as Tools for Developing Social–Emotional Skills
Authors: Majadly Haifaa , Haj Yahya Athar
Published: October 2024

Social–emotional learning (SEL) is recognized as an important component of the educational system, significantly impacting student success. This study aims to examine how Arabic language textbooks used in Arab elementary schools in Israel serve as tools for developing social–emotional skills, beyond their role in language instruction. Using a content analysis and semiological analysis on nine ‘Arabic Our Language’ textbooks for Grades 1 to 6, the findings revealed that all categories of social–emotional skills defined by CASEL were represented, but with an imbalance in their prevalence. Interpersonal relationship skills were the most frequent, while social awareness was the least represented, despite its importance in the Israeli context, which is the context in which this study takes place. Additionally, lower grades (1–3) showed a lack of SEL content compared to higher grades (4–6), even though an early integration of these skills is more effective. Furthermore, the SEL content did not always align with the fundamental principles for optimal implementation. This study emphasizes the need for curricula and textbooks in Arabic language education that are adapted to each developmental stage and tailored to the Israeli socio-cultural context. The findings underscore the critical role of Arabic language textbooks in fostering a holistic educational experience, preparing students for both academic and social success, and serve as a call to action for curriculum designers and textbook authors to integrate social–emotional learning in linguistic educational materials.
The Good and Bad of AI Tools in Novice Programming Education
Authors: Zviel-Girshin Rina
Published: October 2024

As AI coding tools become more prevalent in programming, it is essential to understand how they influence programming education. This study, conducted in a first-semester Introduction to Programming course, aimed to determine the positive and negative effects of these tools on students’ learning experiences and their ability to develop essential programming skills. Using a mixed-methods approach, we collected data from 73 teams of engineering students over a 12-week period. Students completed surveys and reported on their AI tool usage. We analyzed this data quantitatively to identify trends in tool familiarity, usage, and student satisfaction. Additionally, qualitative analysis of student reports provided insights into the specific ways AI tools were used and their perceived benefits and drawbacks. The findings revealed a significant increase in AI tool familiarity (from 28% to 100%) and usage among students. Students’ satisfaction with AI tools improved over time. The most prevalent tasks for which novice programmers used AI tools included creating comments (91.7%), identifying and correcting bugs (80.2%), and seeking information (68.5%), while other tasks were less common. While these tools offered benefits like assisting in learning and enhancing real-world relevance, they also raised concerns about cheating, over-reliance on AI tools, and a limited understanding of core programming concepts.
An Extra-High Voltage Test System for Transmission Expansion Planning Studies Considering Single Contingency Conditions
Authors: Dhamala Bhuban , Ghassemi Mona
Published: October 2024

This paper presents an extra-high voltage synthetic test system that consists of 500 kV and 765 kV voltage levels, specifically designed for transmission expansion planning (TEP) studies. The test network includes long transmission lines whose series impedance and shunt admittance are calculated using the equivalent π circuit model, accurately reflecting the distributed nature of the line parameters. The proposed test system offers technically feasible steady-state operation under normal and all single contingency conditions. By incorporating accurate modeling for long transmission lines and EHV voltage levels, the test system provides a realistic platform for validating models and theories prior to their application in actual power systems. It supports testing new algorithms, control strategies, and grid management techniques, aids in transmission expansion planning and investment decisions, and facilitates comprehensive grid evaluations. Moreover, a TEP study is conducted on this test system and various scenarios are evaluated and compared economically.
A Scaled Monocular 3D Reconstruction Based on Structure from Motion and Multi-View Stereo
Authors: Zhan Zhiwen , Yang Fan , Jiang Jixin , Du Jialin , Li Fanxing , Sun Si , Wei Yan
Published: October 2024

Three-dimensional digital modeling at actual scales is essential for digitally preserving cultural relics. While 3D reconstruction using a monocular camera offers a cost-effective solution, the lack of scale information in the resulting models limits their suitability for geometric measurements. Objects with monotonous textures, such as batteries, pose additional challenges due to insufficient feature points, increasing positional uncertainty. This article proposes a method incorporating point and line features to address the scale ambiguity in multi-view 3D reconstruction using monocular cameras. By pre-measuring the lengths of multiple sets of real line segments, building a lookup table, and associating the line features in different images, the table was input into the improved reconstruction algorithm to further optimize the scale information. Experimental results on real datasets showed that the proposed method outperformed the COLMAP method by 70.82% in reconstruction accuracy, with a scale recovery reaching millimeter-level accuracy. This method is highly generalizable, cost-effective, and supports lightweight computation, making it suitable for real-time operation on a CPU.
Cross-Cultural Psychology and Compassion
Authors: Kotera Yasuhiro , Martínez-Rives Noelia Lucía , Aledeh Muhammad , Colman Rory , Veasey Christian , Harrington Tracey , Komori Naomi , Ozaki Akihiko , Griner Derek , Ali Yumna , Taylor Elaina C.
Published: October 2024

Cross-cultural psychology evaluates how cultural factors influence people’s behaviour and mental processes. Cross-cultural psychology aims to understand individual differences and commonalities, and to develop an appreciation, respect, and knowledge of cultures distinct from one’s own. Compassion refers to the emotional response of understanding, empathising with, and desiring to alleviate or reduce the suffering or distress of others. Compassion involves noticing the pain or difficulties another person is experiencing and being motivated to help, often characterised by acts of kindness, support, and caring. This entry paper explores the intersection of these two concepts, illustrating how insights from cross-cultural psychology can contribute to fostering compassion.
Human Stem Cell Therapy for the Cure of Type 1 Diabetes Mellitus (T1D): A Hurdle Course between Lights and Shadows
Authors: Calafiore Riccardo , Luca Giovanni , Gaggia Francesco , Basta Giuseppe
Published: October 2024

Background: T1D is a severe metabolic disorder due to selective autoimmune pancreatic islet β-cell killing, which results in complete abrogation of endogenous insulin secretion. The affected patients, once the disease is clinically overt, must immediately undertake insulin supplementation according to intensive therapy regimens to prevent the onset of acute and chronic complications, some of them potentially lethal. Replacement of the destroyed β-cells with fresh and vital pancreatic endocrine tissue, either of the whole organ or isolated islets transplantation, started a few decades ago with progressively encouraging results, although exogenous insulin withdrawal was obtained in a minor cohort of the treated patients. The restricted availability of donor organs coupled with general immunosuppression treatment of recipients to avoid graft immune rejection may, at least partially, explain the limited success achieved by these procedures. Results: The introduction of pluripotent stem cells (either of human embryonic origin or adult cells genetically induced to pluripotency) that can be differentiated toward insulin secretory β-like cells could provide an indefinite resource for insulin-producing cells (IPCs). Conclusions: Because the use of human embryos may encounter ethical problems, employment of adult multipotent mesenchymal stem cells (MSCs) extracted from several tissues may represent an alternative option. MSCs are associated with strong immunoregulatory properties that can alter early stages of β-cell-directed autoimmunity in T1D, other than holding the potential to differentiate themselves into β-like cells. Lights and shadows of these new strategies for the potential cure of T1D and their advancement state are reviewed.
Examining the Utility of the Mammalian Methylation Array for Pan-Mammalian Analysis of Monozygotic Twinning
Authors: van Dongen Jenny , Breeze Charles E. ,   Twinning Genetics Consortium
Published: October 2024

Background/Objectives: Human identical twins are born at a rate of 3–4 per 1000 live births. Many other mammals also occasionally produce monozygotic twins, referred to as sporadic polyembryony. The underlying mechanisms are unknown. Through epigenome-wide association studies (EWAS), we identified a robust DNA methylation signature in somatic tissues from human monozygotic (MZ) twins, comprising 834 differentially methylated positions (MZ-DMPs). The results point to a connection between monozygotic twinning and early genome programming and enable new angles to study monozygotic twinning. Methods: The mammalian methylation array (MMA) measures 38,608 CpGs focusing on regions that are well-conserved across many mammalian species, allowing for pan-mammalian comparative epigenomic studies. Here, we successfully map human MZ-DMPs to probes of the mammalian methylation array across 157 mammalian genomes. Results: As expected, based on the modest probe overlap between Illumina 450k/EPIC and mammalian methylation array probes, only a subset of MZ-DMPs reside in conserved regions covered by the mammalian methylation array. These include probes mapping to NPAS3, KLHL35, CASZ1, and ATP2B2. Re-analysis restricting the original EWAS in humans to conserved MMA regions yielded additional MZ-DMPs, suggesting that more loci may be detected by application of the mammalian array to monozygotic twins. Conclusions: In conclusion, the mammalian methylation array may prove to be a promising platform to study whether a shared DNA methylation signature of sporadic polyembryony exists across diverse mammalian species. This may potentially point to shared underlying mechanisms.
Comparative Study on Vascular Bundle Morphological Characteristics of Parts of Branches, Culms, and Rhizomes of Oligostachyum sulcatum
Authors: Zhao Peng , Zhang Kangjian , Zhou Liang , Wei Jinguang , Tian Genlin , Gao Wenli , Jiang Zehui , Wang Youhong
Published: October 2024

This study presents a comprehensive analysis of the vascular bundle morphology, tangential and radial diameters, and distribution frequency of different parts of Oligostachyum sulcatum, elucidating their structural and functional significance. Electron microscopy images revealed distinct vascular bundle characteristics in the different parts, including the vascular bundles in both parts of the rhizomes, the middle parts of the internodes, and the middle and inner parts of the branches, which were semi-open. The vascular bundles in the outer parts of both internodes and branches were semi-differentiated and undifferentiated. The vascular bundles in the inner parts of internodes were open. Statistical analysis showed significant variations in tangential and radial diameters among these parts, reflecting their diverse mechanical and physiological functions. The internodes exhibited the largest tangential and radial diameters, suggesting a critical role in mechanical support. In contrast, the branches had the smallest diameter, indicating that vascular bundle differentiation is influenced by growth conditions. The vascular bundle frequency was the highest in branches and the lowest in inside-sticks. This study provides theoretical references for the adaptive strategies and growth regulation mechanisms of O. sulcatum.