bluuebunny/crossref_metadata_2025 huggingface dataset:
Unveiling the Health-Promoting Power of Bioactive Compounds in Herbs and Spices
Authors: Spence Charles
Published: November 2024

Purpose of Review

The bioactive compounds present as natural constituents in a variety of herbs and spices, as well as in various other foods, provide health benefits beyond the basic nutritional value of the ingredients themselves. This review considers the various ways in which the consumption of herbs and spices may help to promote human health.

Recent Findings

A growing body of research supports the view that people should be encouraged to increase their consumption of herbs and spices, given the wide range of putatively beneficial effects on people’s health that have been reported to date.

Many of the studies reporting health benefits associated with the bioactive compounds in herbs and spices tend to be statistically underpowered, and hence currently provide only weak support for many of the health claims that have been made/published in the literature. Furthermore, few Randomized Controlled Trials (RCTs), the gold standard for evaluating the efficacy of pharmaceuticals, have been published to date. Relevant safety concerns that have been reported are also briefly discussed. Nevertheless, taken as a whole, there would appear to be moderately strong support for the beneficial effects of various bioactive compounds in herbs and spices. Looking to the future, the potential health benefits, combined with the desirable sensory qualities of various herbs and spices, means that their increased usage in our cuisine should be encouraged. At the same time, however, it would undoubtedly also be helpful to see more RCTs assessing specific health claims associated with the consumption of (the bioactive compounds in) herbs and spices, either when taken individually or else in synergistic combination.
Positive reappraisal and catastrophizing mediate the relationship between mindfulness and job burnout
Authors: Ayele Fitsum A. , Barchard Kimberly A.
Published: November 2024

Mindfulness is well-established as a viable treatment for job burnout. However, the mechanisms underlying mindfulness’s burnout-reducing effect remain unclear. Drawing on mindfulness-to-meaning theory, the purpose of this study was to explore two potential mediators of the mindfulness-burnout relationship: positive reappraisal and catastrophizing. Participants were 325 Amazon Mechanical Turk workers who completed the Five Facet Mindfulness Questionnaire, the Positive Reappraisal and Catastrophizing subscales of the Cognitive Emotion Regulation Questionnaire, and the Oldenburg Burnout Inventory. Using a cross-sectional design, we tested six mediation models in which the effect of mindfulness or one of its five facets on burnout was mediated by positive reappraisal and catastrophizing. As expected, burnout correlated with mindfulness (r = − 0.60, p < 0.001), positive reappraisal (r = − 0.59, p < 0.001), and catastrophizing (r = 0.36, p < 0.001), while mindfulness correlated with positive reappraisal (r = 0.58, p < 0.001) and catastrophizing (r = − 0.47, p < 0.001). Positive reappraisal mediated the mindfulness-burnout relationship for all six mindfulness predictors, while catastrophizing mediated the link for two. Planned contrasts indicated that, for all mindfulness predictors, positive reappraisal had significantly stronger indirect effects on burnout than did catastrophizing. These mediation results suggest multiple pathways by which mindfulness acts to reduce burnout. Thus, individuals experiencing burnout may have flexibility in choosing which mindfulness skills to develop to reduce symptoms. However, positive reappraisal better explained the mindfulness-burnout relationship than did catastrophizing. Future research could focus on mindfulness interventions that target positive reappraisal.
Design of the safety climate thermometer to promote team dialogue in surgical teams, using a thematic literature review and international expert panel study
Authors: van der Linde E. M. , Wauben L. S. G. L. , Benishek L. E. , Padmos N. E. , van Grevenstein W. M. U. , Lange J. F. , Burdorf A. , Coert J. H. , Heetman J. G. , Dekker-van Doorn C. M.
Published: November 2024

Introduction

A safe work climate benefits patients and healthcare professionals. Most instruments for evaluating safety climate are lengthy questionnaires focusing on either measuring and benchmarking, or identifying areas for improvement. We aimed to design a communication instrument promoting team discussion about safety in surgical teams: the safety climate thermometer (SCT).

Method

First, a literature study was conducted to identify important safety themes, which were then organized into eight safety climate themes. Behavior-based assessment statements were drafted per theme. Second, an expert panel study with international experts was conducted, soliciting feedback on our initial SCT design. Their feedback led to a redesign into the SCT prototype presented in this study.

Results

The literature search yielded twelve existing instruments and three reviews. Twenty-two experts participated in the panel study. The final SCT prototype framed eight safety climate themes and is organized into two parts. In Part I, team members individually and anonymously evaluate team performance per theme by responding to a single statement to quickly assess global perceptions of that theme. Based on their collective scores, the team chooses one safety climate area to investigate further by scoring one set of eight in-depth statements. In Part II, a structured interdisciplinary team discussion takes place aiming to pinpoint a work floor issue and set actionable goals for improvement.

Discussion/conclusion

The SCT is a communication instrument for surgical teams that first focuses on identifying opportunities for improvement, and then structuring team discussion and follow-up, aiming to improve safety climate.
Exploring the structural stability, thermal and mechanical properties of nanoporous carbon nitride nanosheets using a transferrable machine learning interatomic potential
Authors: Mortazavi Bohayra , Rabczuk Timon , Zhuang Xiaoying
Published: November 2024

Nanoporous carbon nitride nanosheets (NPCNNs) currently stand as one of the most promising classes of two-dimensional materials, exhibiting exceptional properties, wide range of applications and continuous experimental realization of novel structures. However, from a theoretical standpoint, detecting their most stable configurations and accurately evaluating their mechanical and thermal properties are challenging. To effectively address these obstacles, here for the first time we have developed a transferable machine learning interatomic potential (MLIP), capable of substantially facilitating the detection of dynamically stable configurations. Through comprehensive analysis of the mechanical properties of diverse NPCNNs, it is shown that the developed model could with negligible computational cost and remarkable accuracy reproduce directional-dependent stress–strain curves and failure mechanisms predicted by density functional theory calculations. It is furthermore shown that the developed model could conveniently detect the complex corrugated stable configurations, and moreover highlight that the resulting mechanical and electronic properties might be considerably different from their dynamically unstable flat counterparts. The developed transferable MLIP can thus offer an accurate and fast solution to explore the structural stability, and mechanical responses at ground state, and moreover investigate the temperature dependent properties of the NPCNNs, thus substantially facilitating deeper insights into their physical properties and potential applications.
The integral Chow ring of $\mathcal {M}_{1,n}$ for $n=3,\dots ,10$
Authors: Bishop Martin
Published: November 2024

We compute the integral Chow ring of the moduli stack of smooth elliptic curves withnmarked points for$3\leq n\leq 10$.
“An Exact Union of System”: Bute's Cabinet Revolution and Imperial Reform, 1762–63
Authors: Paulett Robert
Published: November 2024

In his brief ministerial career, John Stuart, third Earl of Bute, undertook a project to remake how the king's ministers would perform. Eschewing the personal power accorded to ministers like William Pitt and the Duke of Newcastle under George II, Bute and the young King George III attempted to reform the cabinet into a place of debate, unity, and resolution where administration was shared by all ministers equally. In this they were following the moral and aesthetic sensibilities of the age into a new form of political arrangements, adapting the 1688 settlement into a structure capable of administering territorial empire so long as one did not look too closely at issues of sovereignty or representation. The seemingly small and inconsistently applied shift nonetheless had enormous consequences as it shaped the hemisphere-defining policies of Bute's ministry: the Treaty of Paris of 1763 and the Royal Proclamation of 1763 that followed close on its heels. While historical accounts of Britain's 1763–83 imperial crisis tend to focus on the revenue schemes of 1764–65 as the primary origin point for conflict, Bute's “cabinet revolution” played a larger role than has generally been acknowledged in setting the stage for grander visions of imperial power and the larger protests over that power.
Lubrication-mediated rebounds off fluid baths
Authors: Phillips K.A. , Milewski P.A.
Published: November 2024

We present herein the derivation of a lubrication-mediated (LM) quasi-potential model for droplet rebounds off deep liquid baths, assuming the presence of a persistent dynamic air layer which acts as a lubricating pressure transfer. We then present numerical simulations of the LM model for axisymmetric rebounds of solid spheres and compare quantitatively to current results in the literature, including experimental data in the low-speed impact regime. In this regime the LM model has the advantage of being far more computationally tractable than direct numerical simulation (DNS) and is also able to provide detailed behaviour within the micro-metric thin lubrication region. The LM system has an interesting mathematical structure, with the lubrication layer providing a free-boundary elliptic problem mediating the drop and bath free-boundary evolutionary equations.
Homogeneous turbophoresis of heavy inertial particles in turbulent flow
Authors: Bec Jérémie , Vallée Robin
Published: November 2024

Heavy particles suspended in turbulent flow possess inertia and are ejected from violent vortical structures by centrifugal forces. Once piled up along particle paths, this small-scale mechanism leads to an effective large-scale drift. This phenomenon, known as ‘turbophoresis’, causes particles to leave highly turbulent regions and migrate towards calmer regions, explaining why particles transported by non-homogeneous flows tend to concentrate near the minima of turbulent kinetic energy. It is demonstrated here that turbophoretic effects are just as crucial in statistically homogeneous flows. Although the average turbulent activity is uniform, instantaneous spatial fluctuations are responsible for inertial-range inhomogeneities in the particle distribution. Direct numerical simulations are used to probe particle accelerations, specifically how they correlate to local turbulent activity, yielding an effective coarse-grained dynamics that accounts for particle detachment from the fluid and ejection from excited regions through a space- and time-dependent non-Fickian diffusion. This leads to cast fluctuations in particle distributions in terms of a scale-dependent Péclet number

${\textit {Pe}}_\ell$

, which measures the importance of turbulent advection compared with inertial turbophoresis at a given scale

$\ell$

. Multifractal statistics of energy dissipation indicate that

$ {\textit {Pe}}_\ell \sim \ell ^\delta /\tau _{p}$

with

$\delta \approx 0.84$

. Numerical simulations support this behaviour and emphasise the relevance of the turbophoretic Péclet number in characterising how particle distributions, including their radial distribution function, depends on

$\ell$

. This approach also explains the presence of voids with inertial-range sizes, and the fact that their volumes have a non-trivial distribution with a power-law tail

$p(\mathcal {V}) \propto \mathcal {V}^{-\alpha }$

, with an exponent

$\alpha$

that tends to 2 as

${\textit {Pe}}_\ell \to 0$

.
Vivir en calma: Crimen organizado y vida cotidiana en Durango, México
Authors: Treviño-Rangel Javier
Published: November 2024

Estas notas de investigación son el resultado de un proceso etnográfico accidental e involuntario realizado a lo largo de 2023 en el estado de Durango, en el norte de México. Son un análisis preliminar de la información recolectada sobre la evidente presencia del crimen organizado y sus efectos en la vida cotidiana de los ciudadanos. La mayoría de los estudios sobre violencia en México —y América Latina— tienden a tratar situaciones de violencia extrema; o se enfocan en la población pobre y marginada, que sufre distintos tipos de opresión. Estas notas retratan una situación distinta en dos sentidos. Primero, surgen del trabajo de campo realizado en un entorno de aparente tranquilidad: Durango es actualmente uno de los estados más pacíficos del país, si se mide la paz por número de homicidios. Solo un centenar de personas son asesinadas anualmente, lo que es una anomalía en un país cruento, que reporta más de treinta mil muertes violentas cada año. Segundo, las notas emergen, principalmente, del testimonio de las clases medias y altas, segmentos de la población que también sufren las consecuencias de la violencia, pero que han sido largamente ignorados por la literatura. La investigación evidencia que el crimen organizado condiciona significativamente la vida cotidiana de los ciudadanos que viven en paz, pero con miedo. Los grupos criminales perturban el trabajo y el ocio de los ciudadanos, así como su relación con el gobierno. Este estudio también reflexiona sobre cómo el crimen organizado repercute en el funcionamiento normal del Estado y la democracia liberal.
Supporting Public Humanities at the Critical Intersections: An Imagining America Manifesto
Authors: Kohl-Arenas Erica
Published: November 2024

Drawing upon findings from an Imagining America research project funded by the Mellon Foundation (2019–2023), this research paper and manifesto proposes five critical ways in which institutions of higher education can better support public humanities. Through over one hundred individual interviews, twenty multimedia case studies, a national graduate scholar survey, an online study group, and public conversations, we learned how public scholars have consistently conducted research that matters – responding to urgent challenges in the world, including on the pressing ecological, social, racial, and economic justice issues of our time. However, the diverse inter-generational Imagining America (IA) research team also found that most academic institutions are still not designed to support this important work. By favoring narrow disciplinary boundaries and norms and individualized methods over collective commitments and reciprocal partnerships, most institutions marginalize and disincentivize public humanities. Our research respondents overwhelmingly agreed that instead of change initiatives led from the top of the university, publicly engaged scholars themselves lead the way by virtue of their groundbreaking collaborative, relational, reflective, critical yet hopeful grounded research. The manifesto shared at the end of the paper proposes how to support this important work today.
No effects of high- v. low-protein breakfast on body composition and cardiometabolic health in young women with overweight: the NewStart randomised trial
Authors: Dalgaard Line Barner , Thams Line , Skovgaard Jensen Jon , Jørgensen Astrid Ank , Breenfeldt Andersen Andreas , Gejl Kasper Degn , Bertram Hanne Christine , Hansen Mette
Published: November 2024

The aim of this randomised controlled trial was to investigate the effects of breakfast high or low in protein on body composition and cardiometabolic markers in young women with overweight. In total, fifty-six women aged 18–30 years consumed a breakfast containing either high protein (34 g protein, n 26) or low protein (6 g protein, n 30) for 12 weeks. Measurements of body composition by dual-energy X-ray absorptiometry, waist circumference, glucose tolerance, fasting glucose, insulin and lipid profile were performed before and after this period. The primary outcome was fat mass. Satiety and hunger were evaluated by self-reported Visual Analogue Scale (VAS) scores. Dietary intake was estimated by 4-d dietary records, and calcium intake was estimated by FFQ. At baseline, relative daily protein intake was 15·2 ± 2·8 E%, which increased to 19·3 ± 3·4 E% in high protein but was unchanged in low protein (P < 0·001 between groups). High protein reported higher satiety compared with low protein (P = 0·02). Yet, no group differences were observed in changes in energy intake, body composition, blood lipid profile or measures of glucose tolerance (all P > 0·10). However, bone mineral content tended to increase in high protein (P = 0·05) and decrease in low protein (P = 0·07, interaction effect: P = 0·01). Conclusively, a high v. low content of protein in breakfast increased satiety but did not affect body composition or cardiometabolic markers in young women with overweight. This study adds to the sparse evidence on the effects of breakfast with different macronutrient compositions on health parameters in women with overweight. Registered at clinicaltrials.gov: NCT04518605.
Fractal interpolant curve fitting and reproducing kernel Hilbert spaces
Authors: Luor Dah-Chin , Liu Chiao-Wen
Published: November 2024

In this paper,the linear space $\mathcal F$ of a special type of fractal interpolation functions (FIFs) on an interval I is considered. Each FIF in $\mathcal F$ is established from a continuous function on I. We show that, for a finite set of linearly independent continuous functions on I, we get linearly independent FIFs. Then we study a finite-dimensional reproducing kernel Hilbert space (RKHS) $\mathcal F_{\mathcal B}\subset\mathcal F$, and the reproducing kernel $\mathbf k$ for $\mathcal F_{\mathcal B}$ is defined by a basis of $\mathcal F_{\mathcal B}$. For a given data set $\mathcal D=\{(t_k, y_k) : k=0,1,\ldots,N\}$, we apply our results to curve fitting problems of minimizing the regularized empirical error based on functions of the form $f_{\mathcal V}+f_{\mathcal B}$, where $f_{\mathcal V}\in C_{\mathcal V}$ and $f_{\mathcal B}\in \mathcal F_{\mathcal B}$. Here $C_{\mathcal V}$ is another finite-dimensional RKHS of some classes of regular continuous functions with the reproducing kernel $\mathbf k^*$. We show that the solution function can be written in the form $f_{\mathcal V}+f_{\mathcal B}=\sum_{m=0}^N\gamma_m\mathbf k^*_{t_m} +\sum_{j=0}^N \alpha_j\mathbf k_{t_j}$, where ${\mathbf k}_{t_m}^\ast(\cdot)={\mathbf k}^\ast(\cdot,t_m)$ and $\mathbf k_{t_j}(\cdot)=\mathbf k(\cdot,t_j)$, and the coefficients γm and αj can be solved by a system of linear equations.
Moishezon manifolds with no nef and big classes
Authors: Jia Jia , Meng Sheng
Published: November 2024

We show that a compact complex manifold X has no non-trivial nef $(1,1)$-classes if there is a non-biholomorphic bimeromorphic map $f\colon X\dashrightarrow Y$, which is an isomorphism in codimension 1 to a compact Kähler manifold Y with $h^{1,1}=1$. In particular, there exist infinitely many isomorphic classes of smooth compact Moishezon threefolds with no nef and big $(1,1)$-classes. This contradicts a recent paper (Strongly Jordan property and free actions of non-abelian free groups, Proc. Edinb. Math. Soc., 65(3) (2022), 736–746).
Hilbert type operators acting from the Bloch space into Bergman spaces
Authors: Tang Pengcheng
Published: November 2024

Let µ be a finite positive Borelmeasure on $[0,1)$ and $\alpha \gt -1$. The generalized integral operator of Hilbert type $\mathcal {I}_{\mu_{\alpha+1}}$ is defined on the spaces $H(\mathbb{D})$ of analytic functions in the unit disc $\mathbb{D}$ as follows:
\begin{equation*}\mathcal {I}_{\mu_{\alpha+1}}(f)(z)=\int_{0}^{1} \frac{f(t)}{(1-tz)^{\alpha+1}}d\mu(t),\ \ f\in H(\mathbb{D}),\ \ z\in \mathbb{D} .\end{equation*}

In this paper, we give a unified characterization of the measures µ for which the operator $\mathcal {I}_{\mu_{\alpha+1}}$ is bounded from the Bloch space to a Bergman space for all $\alpha \gt -1$. Additionally, we also investigate the action of $\mathcal {I}_{\mu_{\alpha+1}}$ from the Bloch space to the Hardy spaces and the Besov spaces.
A comprehensive review on the impact of hesperidin and its aglycone hesperetin on metabolic dysfunction-associated steatotic liver disease and other liver disorders
Authors: Sivaslioglu Aysegul , Goktas Zeynep
Published: November 2024

The purpose of this review is to examine the effects of hesperidin and hesperetin on liver disorders. Metabolic dysfunction-associated steatotic liver disease is a complicated disorder influenced by many factors, including inflammation, diabetes and obesity. Currently, the most prominent treatment method is lifestyle changes. If left untreated, it can progress to cirrhosis, liver fibrosis and liver cancer. Hesperidin, which is a flavanone glycoside polyphenolic plant compound, belongs to the flavanone class and was first isolated from citrus peel. Hesperidin includes aglycone hesperetin and rutinoside sugar. It is the most dominant form of flavonoid in citrus fruits. In our review, we discuss the effects of these phytochemicals on liver diseases, focusing on their relationship with inflammation, blood sugar regulation and blood lipids. Hesperidin and hesperetin are seen as promising agents for many diseases. Their antioxidant and anti-inflammatory properties support this view. Although their low water solubility limits their potential effects, many studies have demonstrated their benefits. They are thought to play an effective role in inflammatory processes, particularly in liver diseases. More studies are required to find the optimum dosage and to use them as a therapeutic agent for the liver.
The intersection of allergy and acute coronary syndrome: a type II Kounis syndrome case report
Authors: Xu Zhanwen , Han Zhe
Published: November 2024

This case report discusses a rare occurrence of type II Kounis syndrome, characterised by an acute myocardial infarction triggered by an allergic reaction. The patient, a young adult male, experienced urticaria soon after eating oysters, which quickly escalated to severe chest discomfort. Despite lacking typical cardiac risk factors, the electrocardiogram showed indications of ST-elevation myocardial infarction. This condition was further complicated by ventricular fibrillation, necessitating urgent life-saving measures. This case demonstrates the intricate and often overlooked relationship between hypersensitivity reactions and cardiovascular events. It highlights the necessity for increased vigilance and rapid diagnostic and treatment approaches in handling Kounis Syndrome, especially in emergency situations. The case underscores the importance of considering allergic causes in acute cardiac scenarios, particularly in patients who do not have standard risk factors for coronary artery disease.
Starch intake and caries increment: A longitudinal study in Finnish adults
Authors: Jangda Fariah H , Suominen Annaliisa L , Lundqvist Annamari , Männistö Satu , Golkari Ali , Bernabé Eduardo
Published: November 2024

Objective:

To evaluate whether changes in starch intake (in terms of amount and food sources) were associated with increments in dental caries among adults.

Design:

This is an 11-year longitudinal study (2000–2011) with duplicate assessments for all variables. A 128-item FFQ was used to estimate intake of starch (g/d) and six starch-rich food groups (potatoes, potato products, roots and tubers, pasta, wholegrains and legumes). Dental caries was assessed through clinical examinations and summarised using the number of decayed, missing and filled teeth (DMFT score). The relationship between quintiles of starch intake and DMFT score was tested in linear hybrid models adjusting for confounders.

Setting:

Northern and Southern regions of Finland.

Participants:

922 adults, aged 30–88 years.

Results:

Mean starch intake was 127·6 (sd: 47·8) g/d at baseline and 120·7 (55·8) g/d at follow-up. Mean DMFT score was 21·7 (6·4) and 22·4 (6·2) at baseline and follow-up. Starch intake was inversely associated with DMFT score cross-sectionally (rate ratio for highest v. lowest quintile of intake: –2·73, 95 % CI –4·64, –0·82) but not longitudinally (0·32, 95 % CI –0·12, 0·76). By food sources, the intakes of pasta (–2·77, 95 % CI –4·21, –1·32) and wholegrains (–1·91, 95 % CI –3·38, –0·45) were negatively associated with DMFT score cross-sectionally but not longitudinally (0·03, 95 % CI –0·33, 0·39 and –0·10, 95 % CI –0·44, 0·24, respectively).

Conclusion:

Changes in the amount and sources of starch intake were not associated with changes in dental caries. Further studies should be conducted in different settings and age groups while focusing on starch digestibility and specific sources of starch.
Effects of Topography on Nutrient Variations in the Western South China Sea
Authors: Huang Fangjuan , Chen Yong , Wang Kuo , Liang Junjian , Liu Qinyu , Xiong Zhiyao , Lan Fei , Yin Kedong
Published: November 2024

A topography change in the continental plain plays an important role in nutrient replenishment mechanisms in oligotrophic oceans. Effects of the topography on the nutrient distribution in the western South China Sea (WSCS) have been overlooked since most studies have focused on the dipole‐induced upwelling and downwelling processes of nutrients. We hypothesize that the seamount topography in the northwestern side of the WSCS contributes to the upward distribution of nutrients. We conducted a cruise to investigate the vertical distribution of nutrients in a large area where there is a gradient in the topography: shallow in the north to deep in the south. Our results showed that the depth contours of nutrients, temperature, and salinity shoaled upward from deep to shallow with their isolines being parallel to the bottom depth. The depth of mixed layer, pycnocline, nutricline, and deep chlorophyll maximum showed the similar topographic effect. In the deep water column of 4,308 m deep, integrated NO3− and PO43– over 0–200 m were 879.60 and 81.78 mmol m−2, but increased to 2010.17 and 143.79 mmol m−2 in the shallow water column of 930 m deep, respectively. The increased supply of nutrients enhanced 0–200 m integrated chlorophyll from 21.71 mg m−2 in the deep water column to 51.51 mg m−2 in the shallow water column. These results demonstrate that topographic elevations such as seamounts induce deep‐to‐shallow shoaling and upwelling that lead to enhanced nutrients and biological production in the euphotic zone of oligotrophic oceans.
Distribution and Characteristics of the Subsurface Eddies in the Aleutian Basin, Bering Sea
Authors: Zhang Kun , Song Haibin , Meng Linghan , Yang Shun
Published: November 2024

Subsurface eddies, characterized by their cores located within or below the pycnocline, can transport materials over long distances in the ocean's interior. Observations of these eddies are sparse, limiting our understanding of their regional distribution and detailed horizontal structures, particularly in high‐latitude areas. The Bering Sea, situated in the subarctic region, is among the world's most productive areas and significantly influences the Arctic Ocean's state, thereby impacting climate change. In this study, we utilize ultrahigh resolution (approximately 10 m) data to investigate the distribution and characteristics of subsurface eddies in the Aleutian Basin, Bering Sea. We detected 44 subsurface eddies in 13 survey transects and analyzed their morphological and hydrographic characteristics, spatial distribution, propagation, and transport. The results show that the average core radius of the subsurface eddies is about 11.62 km and they exhibit complex structures in both the core and flank regions. The dichothermal layer cold‐core eddies are prevalent in the deep‐water region of the Bering Sea, contributing approximately 1.76 Sv poleward and westward transport in the subsurface layer. This is the first three‐dimensional depiction of subsurface eddies in the Bering Sea, revealing that the prevalence of subsurface eddies in the Bering Sea may have been negligent, with significant implications for the hydrographic and biogeochemical properties of both the Bering Sea and the Arctic Ocean. More detailed comprehensive and long‐term observations should be made to assess the global impact of subsurface eddies in the future.
Elevated Heterotrophic Prokaryotic Production Supported by Low Nucleic Acid Prokaryotes at a Cyclonic Eddy Edge in the Northwest Pacific
Authors: Ni Junyi , Chen Mingming , Shen Jiaming , Liu Li , Jiang Zong‐Pei , Zhou Kuanbo , Li Xiaolin , Dai Minhan , Zhang Yao
Published: November 2024

The cyclonic eddy uplifts nutrient‐rich seawater into the euphotic zone, typically directly enhancing phytoplankton abundance and primary production. However, its impact on heterotrophic prokaryotic production (HPP) remains unclear due to the complex interplay of multiple indirect factors governing this process. Here, we conducted a comprehensive investigation of the distribution of picophytoplankton and heterotrophic prokaryotes, prokaryotic community structure, and HPP within a cyclonic eddy in the western North Pacific subtropical gyre. The results indicated that despite the higher abundance of picophytoplankton accompanied by nutrient upwelling at the eddy core compared to the edge, higher levels of HPP were observed at the eddy edge between 100 and 200 m, consistent with the distribution of the low nucleic acid content (LNA) prokaryotes. The significant positive correlation between HPP and the proportion of LNA group in total heterotrophic prokaryotes suggested a primary contribution from the LNA group over the high nucleic acid content (HNA) group. SAR11, a typical member of the LNA group, may primarily contribute to the elevated HPP observed at the eddy edge. The changes in temperature, nutrients, and light intensity induced by the cyclonic eddy may significantly influence the distribution and activity of HNA and LNA groups, potentially exerting a greater impact on HPP compared to phytoplankton‐related factors. These findings contribute to understanding the underlying mechanisms of HPP responses to cyclonic eddies in the oligotrophic open ocean.
Implementing Parameterizations of Sub‐Pixel Terrain Long‐Wave Radiative Effect for FY‐4A/AGRI Infrared Data Assimilation Over Land Based on the Community Radiative Transfer Model
Authors: Li Xin , Huang Anning , Zeng Mingjian , Wu Yang , Gu Chunlei , Wang Ning
Published: November 2024

The sub‐pixel terrain long‐wave radiative effect (STLRE) plays an important role in the satellite surface‐sensitive infrared brightness temperature (TB) simulation over rugged areas, however, it is absent in current radiative transfer models. This study incorporates a STLRE scheme in the Community Radiative Transfer Model (CRTM) for the FY‐4A/Advanced Geosynchronous Radiation Imager (AGRI). The total surface downwelling long‐wave radiance (SDLR) over rugged areas at sub‐pixel is composed of the radiance from the overlying atmosphere under plane‐parallel radiation condition and the radiance emitted from surrounding terrains, weighted by the sky view factor (SKV). Based on the homogenous assumption, a STLRE scheme is established through constructing terrain correction factors at AGRI pixel scale. The ExpCTL/ExpTOPO experiments with the CRTM adopting the plane‐parallel scheme/STLRE scheme are conducted to evaluate the simulations of AGRI clear‐sky TB over the rugged areas. Results show that considering the STLRE can significantly reduce the orography dependent simulation biases in the plane‐parallel scheme. The reductions of biases for the AGRI channel 11–13 regionally averaged over the rugged areas are 64.2%, 72.7% and 67.6%, respectively. Stable correction performance is found at different times of the day. Meanwhile, the corrections of SDLR are more obvious in winter than in summer, and in barren condition than in the other land cover types. This is theoretically attributed to the land‐air temperature difference and the land surface emissivity, respectively. This pilot study improves the observation operator for infrared TB data assimilation over complex terrain and exhibits broad promotion and application value.
The Cold Bias in the Surface Air Temperature Simulations Over the Tibetan Plateau of RegCM4 Reduced by Adopting the 3D Sub‐Grid Terrain Longwave Radiative Effect Scheme
Authors: Gu Chunlei , Huang Anning , Li Xin , Wu Yang
Published: November 2024

The 3D sub‐grid terrain longwave radiative effects (3DSTLRE), which significantly regulate the surface downward longwave radiation (SDLR) in the mountainous regions, are not described in current numerical models. We incorporated a 3DSTLRE scheme into RegCM4 to assess its influence on modeling the surface air temperature (SAT) across the Tibetan Plateau (TP). Results show that the RegCM4 adopting the parallel‐plane longwave radiative scheme significantly underestimates the SAT over TP, this underestimation of SAT is clearly mitigated by considering 3DSTLRE, with the root mean square error (RMSE) decreased by 9%. The SAT simulations are improved more noticeable over western TP than entire TP and more evident at nighttime than at daytime in different seasons. Further analysis indicates that the improvement of SAT simulations over the rugged areas of TP is primarily benefited from the improved SDLR simulations. In the absence of the 3DSTLRE scheme, RegCM4 markedly underestimates SDLR by 20 W·m−2 over the entire TP, this underestimation can be greatly reduced by 15 W·m−2 through adopting the 3DSTLRE scheme, with the RMSE reduced by more than 40% over the rugged edges of TP. The increased SDLR induced by the 3DSTLRE is mainly transformed into sensible heat flux to warm the near surface air, further leading to reduced cold bias of SAT produced by the RegCM4 without 3DSTLRE. Better representing the TP thermal condition can enhance the simulation of East Asian monsoon. Therefore, incorporating the 3DSTLRE scheme in numerical models can potentially improve the ability in simulating and predicting the East Asian monsoon.
Interhemispheric Asymmetry in the High‐Latitude Neutral Density Variations During the 13–14 March 2022 Storm
Authors: Zhu Qingyu , Lu Gang , Vines Sarah , Hairston Marc
Published: November 2024

During the second recovery phase of the 13–14 March 2022 storm, intense high‐latitude neutral mass density spikes are detected by satellites at ∼500 km in both hemispheres. These density spikes, accurately modeled by the Global Ionospheric Thermosphere Model (GITM), are identified as high‐latitude neutral mass density anomalies (HDAs). The GITM simulation indicates that these HDAs, which extends over the polar region, are important features in high‐latitude neutral density. Furthermore, GITM reveals that these HDAs are manifestations of transpolar traveling atmospheric disturbances triggered on the dawn side. Moreover, GITM also reveals significant interhemispheric asymmetries (IHAs) in the magnitude, propagation speed, and propagation direction of HDAs, which are linked to the IHAs in the distribution and magnitude of Joule heating deposited as well as the thermospheric background conditions. This study presents a dynamic perspective on the IHA of storm‐time high‐latitude neutral density variations that is particularly helpful to the proper interpretation of satellite observations.
An optomechanical MEMS geophone with a 2.5 ng/Hz1/2 noise floor for oil/gas exploration
Authors: Jiao Shimin , Qu Ziqiang , Ma Xujin , Ouyang Hao , Xiong Wen , Zhang Shaolin , Wang Qiu , Liu Huafeng
Published: November 2024

High-precision geophones play crucial roles in terrestrial applications such as oil and gas exploration as well as seismic monitoring. The development of optomechanical precision measurements provides a new design method for geophones, offering higher sensitivity and smaller dimensions compared to traditional geophones. In this work, we introduce an optomechanical microelectromechanical system (MEMS) geophone based on a plano-concave Fabry‒Perot (F–P) microcavity, which has a high sensitivity of 146 V/g. The F‒P microcavity consists of a movable mirror on the sensing element and a fixed hemispherical micromirror fabricated from silicon-on-insulator (SOI) and monocrystalline silicon wafers, respectively. The experimental results show that the geophone has a low noise floor of 2.5 ng/Hz1/2 (with a displacement noise floor of 6.2 fm/Hz1/2) within the frequency range of 100~200 Hz, a broad bandwidth of 500 Hz (–3 dB), and a measurement range of ±4 mg. To mitigate common-mode noise originating from the laser source and environmental factors such as temperature and air fluctuations, a balanced detection method is employed. This method substantially reduces the noise floor, nearly reaching the thermal noise limit (2.5 ng/Hz1/2). Furthermore, a compactly packaged optomechanical MEMS geophone with a diameter of 40 mm is demonstrated. The high performance and robust features hold great potential for applications in oil and gas exploration.
Highly dispersive multiplexed micromechanical device array for spatially resolved sensing and actuation
Authors: Gregorat Leonardo , Cautero Marco , Vicarelli Leonardo , Giuressi Dario , Bagolini Alvise , Tredicucci Alessandro , Cautero Giuseppe , Pitanti Alessandro
Published: November 2024

The powerful resource of parallelizing simple devices for realizing and enhancing complex operations comes with the drawback of multiple connections for addressing and controlling the individual elements. Here we report on a technological platform where several mechanical resonators can be individually probed and electrically actuated by using dispersive multiplexing within a single electrical channel. We demonstrate room temperature control of the individual device vibrational motion and spatially-resolved readouts. As the single elements have proven to be excellent bolometers and individual nodes for reservoir computing, our platform can be directly employed for single-channel addressing of multiple devices, with immediate applications for far-infrared cameras, spatial light modulators and recurrent neural networks operating at room temperature.
Epigenetics-targeted drugs: current paradigms and future challenges
Authors: Dai Wanlin , Qiao Xinbo , Fang Yuanyuan , Guo Renhao , Bai Peng , Liu Shuang , Li Tingting , Jiang Yutao , Wei Shuang , Na Zhijing , Xiao Xue , Li Da
Published: November 2024

Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA modification, histone modification, RNA modification, chromatin remodeling, and non-coding RNA regulation. These mechanisms and their associated enzymes convey genetic information independently of DNA base sequences, playing essential roles in organismal development and homeostasis. Conversely, disruptions in epigenetic landscapes critically influence the pathogenesis of various human diseases. This understanding has laid a robust theoretical groundwork for developing drugs that target epigenetics-modifying enzymes in pathological conditions. Over the past two decades, a growing array of small molecule drugs targeting epigenetic enzymes such as DNA methyltransferase, histone deacetylase, isocitrate dehydrogenase, and enhancer of zeste homolog 2, have been thoroughly investigated and implemented as therapeutic options, particularly in oncology. Additionally, numerous epigenetics-targeted drugs are undergoing clinical trials, offering promising prospects for clinical benefits. This review delineates the roles of epigenetics in physiological and pathological contexts and underscores pioneering studies on the discovery and clinical implementation of epigenetics-targeted drugs. These include inhibitors, agonists, degraders, and multitarget agents, aiming to identify practical challenges and promising avenues for future research. Ultimately, this review aims to deepen the understanding of epigenetics-oriented therapeutic strategies and their further application in clinical settings.
New-to-nature CO2-dependent acetyl-CoA assimilation enabled by an engineered B12-dependent acyl-CoA mutase
Authors: Schulz-Mirbach Helena , Wichmann Philipp , Satanowski Ari , Meusel Helen , Wu Tong , Nattermann Maren , Burgener Simon , Paczia Nicole , Bar-Even Arren , Erb Tobias J.
Published: November 2024

Acetyl-CoA is a key metabolic intermediate and the product of various natural and synthetic one-carbon (C1) assimilation pathways. While an efficient conversion of acetyl-CoA into other central metabolites, such as pyruvate, is imperative for high biomass yields, available aerobic pathways typically release previously fixed carbon in the form of CO2. To overcome this loss of carbon, we develop a new-to-nature pathway, the Lcm module, in this study. The Lcm module provides a direct link between acetyl-CoA and pyruvate, is shorter than any other oxygen-tolerant route and notably fixes CO2, instead of releasing it. The Lcm module relies on the new-to-nature activity of a coenzyme B12-dependent mutase for the conversion of 3-hydroxypropionyl-CoA into lactyl-CoA. We demonstrate Lcm activity of the scaffold enzyme 2-hydroxyisobutyryl-CoA mutase from Bacillus massiliosenegalensis, and further improve catalytic efficiency 10-fold by combining in vivo targeted hypermutation and adaptive evolution in an engineered Escherichia coli selection strain. Finally, in a proof-of-principle, we demonstrate the complete Lcm module in vitro. Overall, our work demonstrates a synthetic CO2-incorporating acetyl-CoA assimilation route that expands the metabolic solution space of central carbon metabolism, providing options for synthetic biology and metabolic engineering.
Reaction blueprints and logical control flow for parallelized chiral synthesis in the Chemputer
Authors: Šiaučiulis Mindaugas , Knittl-Frank Christian , M. Mehr S. Hessam , Clarke Emma , Cronin Leroy
Published: November 2024

Despite recent proliferation of programmable robotic chemistry hardware, current chemical programming ontologies lack essential structured programming constructs like variables, functions, and loops. Herein we present an integration of these concepts into χDL, a universal high-level chemical programming language executable in the Chemputer. To achieve this, we introduce reaction blueprints as a chemical analog to functions in computer science, allowing to apply sets of synthesis operations to different reagents and conditions. We further expand χDL with logical operation queues and iteration via pattern matching. The combination of these new features allows encoding of chemical syntheses in generalized, reproducible, and parallelized digital workflows rather than opaque and entangled single-step operations. This is showcased by synthesizing chiral diarylprolinol catalysts and subsequently utilizing them in various synthetic transformations (13 separate automated runs affording 3 organocatalysts and 12 distinct enantioenriched products in 42–97% yield, up to > 99:1 er), including automated catalyst recycling and reuse.
Operando visualisation of lithium plating by ultrasound imaging of battery cells
Authors: Wasylowski David , Ditler Heinrich , Sonnet Morian , Falkenstein Tim , Leogrande Luca , Ronge Emanuel , Blömeke Alexander , Würsig Andreas , Ringbeck Florian , Sauer Dirk Uwe
Published: November 2024

While developing battery cells, the achievement of fast-charging capability is heavily dependent on avoiding metallic plating on the anode surface (i.e., lithium plating in lithium-ion cells). However, this objective hinges on the effectiveness of plating detection. Currently, measurement techniques are either inadequate in providing spatial, temporal, or causal information, incur high costs when employing, e.g., neutron imaging, or are lengthy due to destructive post-mortem examinations that additionally lack operando data. In this work, we demonstrate an ultrasound imaging method for operando visualization of the interior of a multi-layer pouch battery cell. Here we show that this method can non-invasively visualize the formation and stripping of lithium plating during cycling. Extensive reference electrode studies and ex-situ analysis verify the effectiveness of our method for plating detection. Ultimately, this work enables researchers and industry to significantly accelerate the development of new cell technologies and their optimized utilization.
Eliminating chemo-mechanical degradation of lithium solid-state battery cathodes during >4.5 V cycling using amorphous Nb2O5 coatings
Authors: Jangid Manoj K. , Cho Tae H. , Ma Tao , Liao Daniel W. , Kim Hwangsun , Kim Younggyu , Chi Miaofang , Dasgupta Neil P.
Published: November 2024

Lithium solid-state batteries offer improved safety and energy density. However, the limited stability of solid electrolytes (SEs), as well as irreversible structural and chemical changes in the cathode active material, can result in inferior electrochemical performance, particularly during high-voltage cycling (>4.3 V vs Li/Li+). Therefore, new materials and strategies are needed to stabilize the cathode/SE interface and preserve the cathode material structure during high-voltage cycling. Here, we introduce a thin (~5 nm) conformal coating of amorphous Nb2O5 on single-crystal LiNi0.5Mn0.3Co0.2O2 cathode particles using rotary-bed atomic layer deposition (ALD). Full cells with Li4Ti5O12 anodes and Nb2O5-coated cathodes demonstrate a higher initial Coulombic efficiency of 91.6% ± 0.5% compared to 82.2% ± 0.3% for the uncoated samples, along with improved rate capability (10x higher accessible capacity at 2C rate) and remarkable capacity retention during extended cycling (99.4% after 500 cycles at 4.7 V vs Li/Li+). These improvements are associated with reduced cell polarization and interfacial impedance for the coated samples. Post-cycling electron microscopy analysis reveals that the Nb2O5 coating remains intact and prevents the formation of spinel and rock-salt phases, which eliminates intra-particle cracking of the single-crystal cathode material. These findings demonstrate a potential pathway towards stable and high-performance solid-state batteries during high-voltage operation.
Global distribution and decline of mangrove coastal protection extends far beyond area loss
Authors: Xu Xichen , Fu Dongjie , Su Fenzhen , Lyne Vincent , Yu Hao , Tang Jiasheng , Hong Xiaorun , Wang Juan
Published: November 2024

Mangroves protect coasts from extreme weather and erosion but can be destroyed by climate change and harvesting. However, there is no consistent formulation of protective capacity that integrates key factors such as area, width, height, and health. Here, we quantified and analyzed a process-based measure of mangrove coastal protection index (MCPI) incorporating cross-shore width, canopy height, and the normalized difference vegetation index (health index). Width/area generally declined at low rates but width increases in some regions reduced MCPI. Cluster exchange network analysis from 2007 to 2019 showed an 800% increase in mangrove forests with characteristically low height, width, and MCPI. Globally, this suggests a 25% decrease in MCPI from 2007 to 2019, primarily from height/biomass change, compared to a 2% decrease in area. Relatively sheltered low-latitude high mangrove strands (>20 m) of high-MCPI appear to be resilient to destruction from cyclones. In contrast, our results highlight an alarming, widespread decline in low MCPI, particularly along coasts exposed to deep water, possibly in concert with human destruction, cyclones, and intensifying oceanic boundary currents.