bluuebunny/crossref_metadata_2025 huggingface dataset:
Figure S8 from An Engineered Self-biomineralized Oncolytic Adenovirus Induces Effective Antitumor Immunity and Synergizes With Immune Checkpoint Blockade
Authors: Wang Shibing , Yang Xue , Ma Ying-Yu , Wu Junjie , Jin Ketao , Zhao Ruibo , Zou Hai , Mou Xiaozhou
Published: November 2024

Figure S8. (A) Flow cytometric analysis of the proportion of CD3+, CD8+ and CD4+ T cells in splenocytes. (B) The virus titers in tumor and sera of 4T1 mice were quantified by the TCID50 method. (C) The relative virus content in 4T1 tumors were quantified by qPCR assay.
Figure S6 from An Engineered Self-biomineralized Oncolytic Adenovirus Induces Effective Antitumor Immunity and Synergizes With Immune Checkpoint Blockade
Authors: Wang Shibing , Yang Xue , Ma Ying-Yu , Wu Junjie , Jin Ketao , Zhao Ruibo , Zou Hai , Mou Xiaozhou
Published: November 2024

Figure S6. Biological safety of the oADV-W6-CaP.
Figure S4 from An Engineered Self-biomineralized Oncolytic Adenovirus Induces Effective Antitumor Immunity and Synergizes With Immune Checkpoint Blockade
Authors: Wang Shibing , Yang Xue , Ma Ying-Yu , Wu Junjie , Jin Ketao , Zhao Ruibo , Zou Hai , Mou Xiaozhou
Published: November 2024

Figure S4. oADV-W6-CaP promotes activation of the type I IFN pathway in Panc02, CT26 and SCC-7 cells.
Figure S1 from An Engineered Self-biomineralized Oncolytic Adenovirus Induces Effective Antitumor Immunity and Synergizes With Immune Checkpoint Blockade
Authors: Wang Shibing , Yang Xue , Ma Ying-Yu , Wu Junjie , Jin Ketao , Zhao Ruibo , Zou Hai , Mou Xiaozhou
Published: November 2024

Figure S1. Particle size of bare oADV-W6 and oADV-W6-CaP.
Supplementary Figure 9 from Tumor-Associated Antigen Burden Correlates with Immune Checkpoint Blockade Benefit in Tumors with Low Levels of T-cell Exhaustion
Authors: Wang Yue , Hu Mengying , Finn Olivera J. , Wang Xiao-Song
Published: November 2024

Supplementary Figure 9. Sensitivities and positive predictive values of TAA burden at different cut points in TCC tumors with unelevated CD8 S3 state in the IMvigor210 (a) and UNC datasets (b).
Figure S8 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity
Authors: Georgiev Peter , Han SeongJun , Huang Amy Y. , Nguyen Thao H. , Drijvers Jefte M. , Creasey Hannah , Pereira Joseph A. , Yao Cong-Hui , Park Joon Seok , Conway Thomas S. , Fung Megan E. , Liang Dan , Peluso Michael , Joshi Shakchhi , Rowe Jared H. , Miller Brian C. , Freeman Gordon J. , Sharpe Arlene H. , Haigis Marcia C. , Ringel Alison E.
Published: November 2024

Supplemental Figure 8
Supplementary Figure 2 from Tumor-Associated Antigen Burden Correlates with Immune Checkpoint Blockade Benefit in Tumors with Low Levels of T-cell Exhaustion
Authors: Wang Yue , Hu Mengying , Finn Olivera J. , Wang Xiao-Song
Published: November 2024

Supplementary Figure 2. Survival ROC curve for TAA burden and Foundation One TMB for predicting patient alive two year after ICB treatment. Kaplan-Meier estimator is used to calculate the sensitivity and specificity for each marker in predicting patient alive at month 24 following ICB treatment based on overall survival data. The R package “survivalROC” is used for this analysis.
Figure S4 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity
Authors: Georgiev Peter , Han SeongJun , Huang Amy Y. , Nguyen Thao H. , Drijvers Jefte M. , Creasey Hannah , Pereira Joseph A. , Yao Cong-Hui , Park Joon Seok , Conway Thomas S. , Fung Megan E. , Liang Dan , Peluso Michael , Joshi Shakchhi , Rowe Jared H. , Miller Brian C. , Freeman Gordon J. , Sharpe Arlene H. , Haigis Marcia C. , Ringel Alison E.
Published: November 2024

Supplemental Figure 4
Supplementary Figure 14 from Tumor-Associated Antigen Burden Correlates with Immune Checkpoint Blockade Benefit in Tumors with Low Levels of T-cell Exhaustion
Authors: Wang Yue , Hu Mengying , Finn Olivera J. , Wang Xiao-Song
Published: November 2024

Supplementary Figure 14. Receiver operating characteristic curves of TAA and CTA burdens and TMB for predicting ICB benefits in a retrospective patient cohort treated with anti-PD1 immune checkpoint inhibition (Liu et al. Nature Medicine 2019). (a) The predictive value of TAB, CTB, and TMB in the overall cohort stratified by CD8 S3 and TMB levels. (b) The predictive value of TAB, CTB, and TMB in the patient cohort that did not receive steroids, stratified by CD8 S3 and TMB levels.
Supplementary Figure 13 from Tumor-Associated Antigen Burden Correlates with Immune Checkpoint Blockade Benefit in Tumors with Low Levels of T-cell Exhaustion
Authors: Wang Yue , Hu Mengying , Finn Olivera J. , Wang Xiao-Song
Published: November 2024

Supplementary Figure 13. The levels of CTA, TAA, and tumor mutation burdens in different cohorts of transitional cell carcinoma patients treated with immune checkpoint inhibitors divided by tertiles of the CD8 T cell S3 scores. (a) The levels of CTA, TAA, and tumor mutation burdens in different patient groups of the IMVigor210 cohort divided by tertiles of the CD8 T cell S3 scores. The PD-L1 immune cell levels are illustrated as colored dots. R, responder (CR/PR), NR, non-responder (PD/SD). (b) The levels of CTA, TAA, and tumor mutation burdens in different groups of transitional cell carcinoma patients treated at UNC (Rose et al) divided by tertiles of the CD8 T cell S3 scores. PD-L1 TC or IC levels are not available in this dataset.
Figure S8 from Engineered CAR-NK Cells with Tolerance to H2O2 and Hypoxia Can Suppress Postoperative Relapse of Triple-Negative Breast Cancers
Authors: Liu Yan , Chen Jiahui , Tian Jia , Hao Yu , Ma Xinxing , Zhou Yehui , Feng Liangzhu
Published: November 2024

Figure S8. The proliferation rates of HER1-CAR-CAT-NK cells incubated with or without the ALG hydrogel were determined by counting the number of cells.
Figure S5 from Engineered CAR-NK Cells with Tolerance to H2O2 and Hypoxia Can Suppress Postoperative Relapse of Triple-Negative Breast Cancers
Authors: Liu Yan , Chen Jiahui , Tian Jia , Hao Yu , Ma Xinxing , Zhou Yehui , Feng Liangzhu
Published: November 2024

Figure S5. Effects of H2O2 and hypoxia exposure on the migration and invasion abilities of parental and brain metastatic MDA-MB-231 cells. (A-B) Optical microscopic observation and corresponding semiquantitative analysis of the migration rates of parental MDA-MB-231 cells (A) and brain metastatic MDA-MB-231 cells (B) treated with different concentrations of H2O2 under normoxic or hypoxic conditions for 24 h. (C-D) Optical microscopic observation and corresponding semiquantitative analysis of the invasion rates of parental MDA-MB-231 cells (C) and brain metastatic MDA-MB-231 cells (D) treated with different concentrations of H2O2 under normoxic or hypoxic conditions for 24 h.
Figure S4 from Engineered CAR-NK Cells with Tolerance to H2O2 and Hypoxia Can Suppress Postoperative Relapse of Triple-Negative Breast Cancers
Authors: Liu Yan , Chen Jiahui , Tian Jia , Hao Yu , Ma Xinxing , Zhou Yehui , Feng Liangzhu
Published: November 2024

Figure S4. The percentages of live parental MDA-MB-231 cells (A) and brain metastatic MDA-MB-231 cells (B) incubated under normoxic or hypoxic conditions for 24 h were determined via propidium iodide staining.
Figure S2 from Engineered CAR-NK Cells with Tolerance to H2O2 and Hypoxia Can Suppress Postoperative Relapse of Triple-Negative Breast Cancers
Authors: Liu Yan , Chen Jiahui , Tian Jia , Hao Yu , Ma Xinxing , Zhou Yehui , Feng Liangzhu
Published: November 2024

Figure S2. HER1 expression levels in 293T cells, parental MDA-MB-231 cells, and brain metastatic MDA-MB-231 cells via real-time PCR (A), western blotting (B) and flow cytometry (C). (***p < 0.001).
Figure S6 from The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and Immunosuppression in Tumors
Authors: Pant Ayush , Jain Aanchal , Chen Yiyun , Patel Kisha , Saleh Laura , Tzeng Stephany , Nitta Ryan T. , Zhao Liang , Wu Caren Yu-Ju , Bederson Maria , Wang William Lee , Bergsneider Brandon Hwa-Lin , Choi John , Medikonda Ravi , Verma Rohit , Cho Kwang Bog , Kim Lily H. , Kim Jennifer E. , Yazigi Eli , Lee Si Yeon , Rajendran Sakthi , Rajappa Prajwal , Mackall Crystal L. , Li Gordon , Tyler Betty , Brem Henry , Pardoll Drew M. , Lim Michael , Jackson Christopher M.
Published: November 2024

Figure S6: Ccr6 ablation delays tumor growth across multiple tumor models and CCR6CCL20 expression correlates with overall survival in cancer patients.
Figure S4 from The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and Immunosuppression in Tumors
Authors: Pant Ayush , Jain Aanchal , Chen Yiyun , Patel Kisha , Saleh Laura , Tzeng Stephany , Nitta Ryan T. , Zhao Liang , Wu Caren Yu-Ju , Bederson Maria , Wang William Lee , Bergsneider Brandon Hwa-Lin , Choi John , Medikonda Ravi , Verma Rohit , Cho Kwang Bog , Kim Lily H. , Kim Jennifer E. , Yazigi Eli , Lee Si Yeon , Rajendran Sakthi , Rajappa Prajwal , Mackall Crystal L. , Li Gordon , Tyler Betty , Brem Henry , Pardoll Drew M. , Lim Michael , Jackson Christopher M.
Published: November 2024

Figure S4: Ccr6-/- Tregs have reduced glycolysis compared to WT Tregs.
Figure S2 from The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and Immunosuppression in Tumors
Authors: Pant Ayush , Jain Aanchal , Chen Yiyun , Patel Kisha , Saleh Laura , Tzeng Stephany , Nitta Ryan T. , Zhao Liang , Wu Caren Yu-Ju , Bederson Maria , Wang William Lee , Bergsneider Brandon Hwa-Lin , Choi John , Medikonda Ravi , Verma Rohit , Cho Kwang Bog , Kim Lily H. , Kim Jennifer E. , Yazigi Eli , Lee Si Yeon , Rajendran Sakthi , Rajappa Prajwal , Mackall Crystal L. , Li Gordon , Tyler Betty , Brem Henry , Pardoll Drew M. , Lim Michael , Jackson Christopher M.
Published: November 2024

Figure S2: CCR6 expression is enhanced in tumor-infiltrating Tregs co-expressing checkpoints and Ccr6 ablation reduces immunosuppressive phenotype.
Data from A Single-Cell Analysis of the NK-Cell Landscape Reveals That Dietary Restriction Boosts NK-Cell Antitumor Immunity via Eomesodermin
Authors: He Junming , Chen Donglin , Xiong Wei , Wang Yuande , Chen Shasha , Yang Meixiang , Dong Zhongjun
Published: November 2024

Abstract
Abnormal metabolism in tumor cells represents a potential target for tumor therapy. In this regard, dietary restriction (DR) or its combination with anticancer drugs is of interest as it can impede the growth of tumor cells. In addition to its effects on tumor cells, DR also plays an extrinsic role in restricting tumor growth by regulating immune cells. NK cells are innate immune cells involved in tumor immunosurveillance. However, it remains uncertain whether DR can assist NK cells in controlling tumor growth. In this study, we demonstrate that DR effectively inhibits metastasis of melanoma cells to the lung. Consistent with this, the regression of tumors induced by DR was minimal in mice lacking NK cells. Single-cell RNA sequencing analysis revealed that DR enriched a rejuvenated subset of CD27+CD11b+ NK cells. Mechanistically, DR activated a regulatory network involving the transcription factor Eomesodermin (Eomes), which is essential for NK-cell development. First, DR promoted the expression of Eomes by optimizing mTORC1 signaling. The upregulation of Eomes revived the subset of functional CD27+CD11b+ NK cells by counteracting the expression of T-bet and downstream Zeb2. Moreover, DR enhanced the function and chemotaxis of NK cells by increasing the accessibility of Eomes to chromatin, leading to elevated expression of adhesion molecules and chemokines. Consequently, we conclude that DR therapy enhances tumor immunity through nontumor autonomous mechanisms, including promoting NK-cell tumor immunosurveillance and activation.
Data from Tumor-Associated Antigen Burden Correlates with Immune Checkpoint Blockade Benefit in Tumors with Low Levels of T-cell Exhaustion
Authors: Wang Yue , Hu Mengying , Finn Olivera J. , Wang Xiao-Song
Published: November 2024

Abstract
Tumor-associated antigens (TAA) are important targets for cancer vaccines. However, TAA-based vaccines have not yet achieved their full potential in clinical trials. In contrast, immune checkpoint blockade (ICB) has emerged as an effective therapy, leading to durable responses in selected patients with cancer. To date, few generalizable associations between TAAs and ICB benefit have been reported, with most studies focusing on melanoma, which has the highest mutation rate in cancer. In this study, we developed a TAA burden (TAB) algorithm based on known and putative TAAs and investigated the association of TAB with ICB benefit. Analysis of the IMvigor210 patient cohort of urothelial carcinoma treated with anti-PDL1 revealed that high tumor mutation burden weakened the association of TAB with ICB benefit. Furthermore, TAB correlated with ICB efficacy in tumors characterized by negative PDL1 staining on immune cells; however, high levels of PDL1 staining on immune cells were linked to T-cell exhaustion. Validation across independent clinical datasets—including urothelial carcinoma cohorts treated with anti-PD1/PDL1 agents and neoadjuvant anti-PD1 trials for head and neck cancers—corroborated the finding that TAB correlates with ICB benefit in tumors with low T-cell exhaustion. Pan-cancer analyses revealed that in most cancer entities, tumors with higher T-cell exhaustion exhibited lower TAB levels, implying possible immunoediting of TAAs in tumors with established antitumor immunity. Our study challenges the prevailing notion of a lack of association between TAAs and ICB response. It also underscores the need for future investigations into the immunogenicity of TAAs and TAA-based vaccine strategies in tumors with low levels of T-cell exhaustion.
Efficacy and Safety of Immune Checkpoint Inhibitors Combined with Chemotherapy or Tyrosine Kinase Inhibitors in Advanced Endometrial Cancer: A Systematic Review and Meta-Analysis
Authors: Li Yuting , Li Shixiu , Liang Juan
Published: November 2024

Objective: The objective of this meta-analysis was to conduct a comprehensive assessment of the therapeutic effectiveness and safety profile of the combination of immune checkpoint inhibitors (ICIs) with either chemotherapy or tyrosine kinase inhibitors (TKIs) in the treatment of advanced-stage endometrial cancer (EC). Methods: This meta-analysis conducted a thorough literature search across PubMed, Cochrane Library, Embase, and Web of Science databases from their earliest records up to November 18, 2023, identifying qualified randomized controlled trials (RCTs), cohort studies, and single-arm trials for inclusion in the analysis. The meta-analysis were performed to quantify and analyzed the evidence from the existing literature, focusing on outcomes including the objective response rate (ORR), disease control rate (DCR), duration of response, overall survival (OS), progression-free survival (PFS), and adverse events (AEs). Results: A total of 13 studies were included. In terms of ICI combined with chemotherapy, the single-arm trials showed that ICI combined with chemotherapy was effective in improving the ORR, but the overall rate of AE was higher. The results based on RCT suggested that ICI combined with chemotherapy resulted in a longer PFS of 12–24 months and OS of 18 months compared to the control group in advanced EC. In terms of ICI combined with TKI, the pooled ORR was 39.0%, the pooled DCR was 79.9%, the pooled OS rate was 50.4%, and the pooled overall AE rate was 95.8%, the pooled grade ≥3 AE rate was 73.8%, the pooled median progression-free survival was 6.126 months, and pooled OS was 15.099 months in advanced EC. Conclusions: The integrative therapeutic approach combining ICIs with chemotherapy or TKIs demonstrates notable clinical efficacy in advanced EC, which can prolong the survival and help disease control. Nevertheless, it is imperative for clinicians to be vigilant regarding the potential for adverse reactions to emerge. In addition, more RCTs are needed to solidify this study’s efficacy and safety further.
Oscillatory Blood Pressure Values in Newborn Infants: Observational Data Over Gestational Ages
Authors: Hillman Noah H. , Williams Howard L. , Petersen Rebecca Y.
Published: November 2024

Introduction: Normative blood pressure (BP) values on preterm infants exist but are based on small cohorts of infants. Utilizing electronic medical records (EMR), we can explore earlier gestational ages (GA) and follow their progression to 40 weeks corrected gestational age (CGA). Methods: A retrospective cohort study of infants within the SSM Health System from July 1, 2013 through June 30, 2023. Infants born at >22 0/7 weeks but <41 weeks GA were included if any BP measurements existed (n = 29,323 infants, 1.4 million BPs). Data were extracted electronically from EMR using Microsoft SQL. Systolic BP (SBP), mean arterial pressures (MAP), and diastolic BP (DBP) were determined for each week of life from birth and percentile ranges (1st to 99th) for infants alive at CGA, and BP patterns for GA determined. Results: Percentiles for SBP, DBP, and MAP are provided. There is a rapid increase in BP at all gestations during the first 2 weeks, thus BP values are higher at any CGA in infants born at an earlier GA than infants born at that GA. For MAP values between the 5th and 10th percentile, the GA is appropriate for first week and then use CGA + 5 mm Hg. After the first week, 2.8 X CGA is between 90 and 95 percentile for SBP. Conclusions: The BP is dependent on the GA at birth and the CGA when it is measured. SBP, MAP, and DBP all increase rapidly in the 2 weeks of life prior to a gradual increase over time.
De servir y devolver pueden contrarrestar el menosprecio y promover la autonomía y subjetividad en niños y niñas.
Authors: Pulido Romero David Alejandro , Sánchez Londoño Néstor Daniel , Jaramillo García Oscar Armando
Published: November 2024

Este artículo tiene como objetivo reflexionar las prácticas de menosprecio en contextos educativos y sus implicaciones en el desarrollo de la autonomía y subjetividad en niños y niñas. En este sentido, este análisis también contribuye a la investigación “De servir y devolver pueden contrarrestar el menosprecio y promover la autonomía y subjetividad en niños y niñas” que se lleva a cabo en dos escuelas, una rural y otra urbana, pertenecientes a la Institución Educativa Normal Superior de Neiva, en Colombia, una zona que ha sido afectada por la violencia y el conflicto armado. La investigación hermenéutica es la estrategia de investigación que respalda este artículo y que permitió profundizar en la comprensión de las prácticas de menosprecio y las interacciones de servir y devolver en la educación. Se concluye que es necesario sensibilizar a la comunidad educativa sobre la importancia de fomentar interacciones positivas para prevenir situaciones de exclusión y discriminación.
La participación familiar en la educación: un enfoque multidimensional hacia el desarrollo integral del estudiante.
Authors: Cantillo De La Rosa Clara Inés
Published: November 2024

La presente investigación pretende interpretar y analizar la experiencia docente en relación con la participación de la familia en la educación, con el fin de promover estrategias efectivas que fomenten la colaboración entre familias y escuelas. La metodología utilizada se basa en una revisión bibliográfica de fuentes secundarias, incluyendo investigaciones previas, artículos académicos y literatura relevante. Los hallazgos y perspectivas de diversos autores se analizan y sintetizan para obtener una comprensión integral del fenómeno estudiado. A partir de la revisión bibliográfica, se identifican tres tipologías principales de participación familiar en la educación: 1) Apoyo educativo desde el hogar, 2) Participación democrática en la toma de decisiones institucionales, y 3) Acompañamiento académico y emocional de los estudiantes. Además, se subraya la importancia de una educación integral y el currículo adaptativo a la realidad operante, que busca desarrollar al individuo de manera holística, abarcando aspectos académicos, valores, capacidad crítica, socialización y habilidades emocionales. El artículo concluye que la participación activa de la familia en el contexto educativo es fundamental para el éxito académico y el desarrollo integral de los estudiantes. Se enfatiza la necesidad de diseñar estrategias inclusivas y adaptadas a las realidades de cada contexto educativo, promoviendo relaciones más horizontales, democráticas y participativas dentro del entorno familiar y escolar. Asimismo, se destaca el papel crucial de las familias en la promoción de experiencias enriquecedoras y en la creación de un ambiente de apoyo para el desarrollo óptimo de los estudiantes.
Mo Dao Zu Shi: adaptando uma web novel para história em quadrinhos
Authors: Silva Beatriz Corrêa Oscar da
Published: November 2024

Visa analisar a adaptação da web novel chinesa Mo Dao Zu Shi para manhua, história em quadrinhos chinesa, considerando os aspectos formais da linguagem dos quadrinhos e o modelo de análise da Teoria da Adaptação, proposto por Linda Hutcheon (2011), que também se preocupa com a recepção das obras e os contextos cultural, histórico e social envolvido. Visando realizar essa análise, foram utilizadas amostras de cenas retiradas do romance e da história em quadrinhos.
Kindlin-2 Phase Separation in Response to Flow Controls Vascular Stability
Authors: Ma Nina , Wu Fangfang , Liu Jiayu , Wu Ziru , Wang Lu , Li Bochuan , Liu Yuming , Dong Xue , Hu Junhao , Fang Xi , Zhang Heng , Ai Ding , Zhou Jing , Wang Xiaohong
Published: November 2024

BACKGROUND:

Atheroprotective shear stress preserves endothelial barrier function, while atheroprone shear stress enhances endothelial permeability. Yet, the underlying mechanisms through which distinct flow patterns regulate EC integrity remain to be clarified. This study aimed to investigate the involvement of Kindlin-2, a key component of focal adhesion and endothelial adherens junctions crucial for regulating endothelial cell (EC) integrity and vascular stability.

METHODS:

Mouse models of atherosclerosis in EC-specific
Kindlin-2
knockout mice (
Kindlin-2

iΔEC

) were used to study the role of Kindlin-2 in atherogenesis. Pulsatile shear (12±4 dynes/cm
2
) or oscillatory shear (0.5±4 dynes/cm
2
) were applied to culture ECs. Live-cell imaging, fluorescence recovery after photobleaching assay, and OptoDroplet assay were used to study the liquid-liquid phase separation (LLPS) of Kindlin-2. Co-immunoprecipitation, mutagenesis, proximity ligation assay, and transendothelial electrical resistance assay were used to explore the underlying mechanism of flow-regulated Kindlin-2 function.

RESULTS:

We found that Kindlin-2 localization is altered under different flow patterns.
Kindlin-2

iΔEC

mice showed heightened vascular permeability.
Kindlin-2

iΔEC

were bred onto
ApoE

−/−

mice to generate
Kindlin-2

iΔEC

;
ApoE

−

/−

mice, which displayed a significant increase in atherosclerosis lesions. In vitro data showed that in ECs, Kindlin-2 underwent LLPS, a critical process for proper focal adhesion assembly, maturation, and junction formation. Mass spectrometry analysis revealed that oscillatory shear increased arginine methylation of Kindlin-2, catalyzed by PRMT5 (protein arginine methyltransferase 5). Functionally, arginine hypermethylation inhibits Kindlin-2 LLPS, impairing focal adhesion assembly and junction maturation. Notably, we identified R290 of Kindlin-2 as a crucial residue for LLPS and a key site for arginine methylation. Finally, pharmacologically inhibiting arginine methylation reduces EC activation and plaque formation.

CONCLUSIONS:

Collectively, our study elucidates that mechanical force induces arginine methylation of Kindlin-2, thereby regulating vascular stability through its impact on Kindlin-2 LLPS. Targeting Kindlin-2 arginine methylation emerges as a promising hemodynamic-based strategy for treating vascular disorders and atherosclerosis.
Novel Adiposity Indices Are Associated With Poor Prognosis in Heart Failure With Preserved Ejection Fraction Without the Obesity Paradox
Authors: Zhang Shuai , Xu Panpan , Wei Tianhao , Wei Changjiang , Zhang Yanling , Lu Huixia , Zhang Cheng
Published: November 2024

Background

There is limited study that illuminates the relationship between obesity indices and prognosis in patients with heart failure with preserved ejection fraction, nor has it been examined whether the obesity paradox persists when using these metrics.

Methods and Results

This study is a post hoc analysis of data from the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial. A total of 3114 individuals were included in our final analysis, and a total of 481 (15.4%) all‐cause deaths, and 389 (12.5%) heart failure hospitalizations were recorded. In a multivariable Cox regression model, compared with patients with a body mass index (BMI) <24.9 kg/m
2
, those with a BMI of 25.0–29.9, 30.0–34.9, and 35–39.9 kg/m
2
were associated with a decreased risk of all‐cause death, with hazard ratio (95% CI) of 0.59 (0.45–0.78), 0.61 (0.46–0.82), and 0.66 (0.47–0.92), respectively. Conversely, patients with a BMI ≥40 kg/m
2
showed an increased risk of heart failure hospitalization, compared with BMI <24.9 kg/m
2
. Furthermore, patients in the highest quintile of obesity indices exhibited a significantly elevated hazard ratio for both all‐cause death and heart failure hospitalization, compared with the lowest quintile.

Conclusions

An elevated BMI over a certain range was associated with a reduced risk of all‐cause death in heart failure with preserved ejection fraction, displaying a U‐shaped relationship, with no mortality reduction observed in cases of extreme obesity. In contrast, higher values of novel obesity indices were positively correlated with all‐cause death and heart failure hospitalization without the obesity paradox.
New species and record in the genus Carbacanthographis (lichenized Ascomycota, Graphidaceae) from China
Authors: JIANG SHU-HAO , HAO CHENG-YUE , ZHAO XIN , JIA ZE-FENG
Published: November 2024

During our research on the lichen genus Carbacanthographis from China, two species new to science were discovered in materials from Yunnan and Guangxi Provinces, i.e. Carbacanthographis crassibasalia sp. nov. with a corticate thallus, a completely carbonized excipulum, warty periphysoid tips, hyaline, muriform, 6–18 × 3–4-septate ascospores, and protocetraric acid and C. yunnanensis sp. nov. with an ecorticate thallus, a completely carbonized excipulum, warty periphysoid tips, hyaline, small, submuriform 4–6 × 0–1-septate ascospores and the presence of protocetraric acid. A new record for China, C. iriomotensis, collected in Hainan Province is also reported. Detailed morphological descriptions as well as high-resolution photographs of the morphology and anatomy of the three species are provided. A working key to all the known Carbacanthographis species from China is also provided.
From Petersburg to Shipka via Mount Athos: Slavic Saints on the Shipka Iconostasis
Authors: Gergova Ivanka
Published: November 2024

From Petersburg to Shipka via Mount Athos: Slavic Saints on the Shipka Iconostasis
The article explores the images of Slavic saints on the iconostasis of the Russian Memorial Church in the town of Shipka in Bulgaria, which were completed in 1899–1901 at the Russian Saint Panteleimon Monastery on Mount Athos. Its main objective is to analyze the iconostasis’s conceptual framework, the meanings behind the selection of the saints, as well as the main iconographical models utilized. The Committee for the Construction of the Memorial Church and its chairperson Count Nikolay Ignatyev conceived of one tier of images of saints depicting the heroes of the Russo-Turkish War of 1877–1878, while a number small icons would feature local Bulgarian and Slavic saints that were to be selected by the monks themselves. The icon painting monks mainly relied on Archbishop Philaret of Chernigov’s book The Saints of the Southern Slavs with engravings by academician Fedor Solntsev as the main source and model for their depictions of saints.
 
Z Petersburga do Szipki przez Górę Athos. Słowiańscy święci na ikonostasie w Szipce
Przedmiotem uwagi są wizerunki słowiańskich świętych na ikonostasie w Cerkwi pw. Narodzenia Pańskiego w Szipce w Bułgarii, które powstały w latach 1899–1901 w rosyjskim klasztorze św. Pantelejmona na Górze Athos. Celem artykułu jest analiza ram koncepcyjnych ikonostasu, znaczeń stojących za wyborem świętych, a także głównych wykorzystanych modeli ikonograficznych. Członkowie Komitetu ds. budowy świątyni upamiętniającej wydarzenia na przełęczy Szipka, wraz z przewodniczącym, hrabią Nikołajem Ignatjewem na czele, wymyślili rząd wizerunków świętych przedstawiających bohaterów wojny rosyjsko-tureckiej z lat 1877–1878. Kilka mniejszych ikon miało przedstawiać lokalnych bułgarskich i słowiańskich świętych, wybranych przez mnichów. Głównym źródłem i wzorcem dla tych przedstawień było dzieło arcybiskupa Filareta (Gumilewskiego) Święci południowosłowiańscy, zawierające ryciny Fiodora Sołncewa.
What Does One Need to Build a Bridge in Slovenia? Research on Slovenian Folk Tales, Games, Dances and Rituals Related to Bridge Construction and the Building Process
Authors: Olszewski Maciej Bolesław
Published: November 2024

What Does One Need to Build a Bridge in Slovenia? Research on Slovenian Folk Tales, Games, Dances and Rituals Related to Bridge Construction and the Building Process
Human sacrifices and supernatural beings are the two most common motifs in folklore material related to bridge-building projects. This article is an attempt to deal with Slovenian folklore material that refers to the act of bridge building and to show which of these motifs seem to be closer to the Slovenian tradition. To achieve this goal, I present examples of Slovenian folktales, dances, games and other folk culture texts. I also highlight the root causes that potentially resulted in the prevalence of one of these motifs.
 
Czego potrzeba, by zbudować most w Słowenii? Badania nad słoweńskimi tekstami ludowymi, grami, tańcami i rytuałami związanymi z budowaniem mostów i procesem budowy
Ofiary zakładzinowe i istoty nadprzyrodzone to dwa motywy najczęściej pojawiające się w tekstach kultury ludowej dotyczących budowania mostów. Artykuł stanowi próbę omówienia słoweńskiego materiału folklorystycznego związanego z budową mostów i pokazania, który z tych motywów wydaje się bliższy słoweńskiej tradycji. W tym celu przedstawiam przykłady zaczerpnięte z zachowanych podań ludowych, gier, tańców i innych tekstów kultury ludowej. Zwracam również uwagę na przyczyny mogące powodować przewagę w częstotliwości występowania jednego z motywów.
Remembering Donna Rockwell in Her Own Words
Authors: Raskin Jonathan D.
Published: November 2024

The late Donna Rockwell had an outsize influence on the Society for Humanistic Psychology. In addition to recounting two important interactions that reflected the personal impact she had, several powerful quotes from Donna are shared to convey her commitment to the principles and practices of humanistic psychology.
How user language affects conflict fatality estimates in ChatGPT
Authors: Steinert Christoph Valentin , Kazenwadel Daniel
Published: November 2024

OpenAI’s ChatGPT language model has gained popularity as a powerful tool for problem-solving and information retrieval. However, concerns arise about the reproduction of biases present in the language-specific training data. In this study, we address this issue in the context of the Israeli–Palestinian and Turkish–Kurdish conflicts. Using GPT-3.5, we employed an automated query procedure to inquire about casualties in specific airstrikes, in both Hebrew and Arabic for the former conflict and Turkish and Kurdish for the latter. Our analysis reveals that GPT-3.5 provides 34 ± 11% lower fatality estimates when queried in the language of the attacker than in the language of the targeted group. Evasive answers denying the existence of such attacks further increase the discrepancy. A simplified analysis on the current GPT-4 model shows the same trends. To explain the origin of the bias, we conducted a systematic media content analysis of Arabic news sources. The media analysis suggests that the large-language model fails to link specific attacks to the corresponding fatality numbers reported in the Arabic news. Due to its reliance on co-occurring words, the large-language model may provide death tolls from different attacks with greater news impact or cumulative death counts that are prevalent in the training data. Given that large-language models may shape information dissemination in the future, the language bias identified in our study has the potential to amplify existing biases along linguistic dyads and contribute to information bubbles.
Benzodiazepine use and incident risk of sudden cardiac arrest in patients with cardiovascular diseases
Authors: Mo Chunbao , Wang Shuang , Li Xia , Li Furong , Jin Cheng , Bai Bo , Pei Haolong , Zheng Jing , Liang Fengchao
Published: November 2024

Background

Benzodiazepines (BZDs) are commonly prescribed as adjunctive drugs for patients with cardiovascular diseases (CVDs), particularly those who experience anxiety or insomnia. However, the relationship between the use of BZDs and incident risk of sudden cardiac arrest (SCA) has not been well investigated. In this study, we aimed to examine the association between the use of BZDs and the incident risk of SCA among patients with CVD.

Method

In this retrospective cohort study, a total of 74,715 eligible patients with new-onset CVD as a primary cause of hospitalization between July 2016 and August 2022 were included from the health information platform in Shenzhen, China. Among them, 61,761 BZD non-initiators were identified and matched to 12,954 BZD initiators by propensity score at a maximum ratio of 5:1. Propensity score-matched Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

Over a 12-month follow-up period, 29 (2.24 per 1000 person-years) and 137 (2.22 per 1000 person-years) SCA cases occurred among propensity score-matched BZD initiators and non-initiators, respectively. Patients who initiated BZD treatment were associated with a 101% increased risk of SCA incidence compared with patients without BZD treatment (adjusted HR: 2.01, 95% CI: 1.42, 2.83). Furthermore, compared with the non-use (0 defined daily dose, DDD), the adjusted HR was 1.43 (95% CI: 1.32, 1.56) for the BZD consumption of ≤1 DDD and 2.58 (95% CI: 2.37, 2.81) for the BZD consumption of >1 DDD ( P for trend < 0.001) within a 12-month follow-up period.

Conclusion

This study provides evidence that BZD initiation may be associated with an increased incident risk of SCA in patients with CVD. Our finding highlights the importance of cautious prescribing BZDs in the health management of patients with CVD.
“Knowing and Working With Someone Who Has Made It Means I’m Going to Make It Too”: Experiential Knowledge as a Catalyst for Transformation in Reentry and Beyond
Authors: Troshynski Emily I. , Willis Carolyn , Forrai Kara
Published: November 2024

Of the 2.2 million adults incarcerated in the United States, between 600,000 and 700,000 return to society annually. The U.S. federal evaluations reveal over a quarter of these individuals are rearrested within 6 months, while studies in more than 40 states find that close to half are reincarcerated within 3 years. Recidivism rates reveal a pressing need to understand reentry from the perspective of those who have experienced it. This study analyzes interviews with previously incarcerated individuals, identifying four key categories of experiential knowledge: impact of clinical staff, re-entry programming staff, mentors, and founder’s experiences. Experiential knowledge, and understandings acquired through direct personal experience, emerge as pivotal in supporting successful reintegration. The discussion highlights its impact beyond reentry, aligning with individuals’ aspirations to help others. By emphasizing the significance of experiential knowledge, conclusions advocate for its integration into re-entry programs to enhance support and services for justice-involved individuals.
A Prospective, Multicenter European Study on the Effects of Anatolian Propolis and Hypertonic Saline Combination Nasal Spray on Allergic Rhinitis Symptoms
Authors: Manole Felicia , Hoermann Karl , Passali Desiderio , Rombaux Philippe , Maria Bellussi Luisa , Rudenko Michael , Milkov Mario , Kopacheva-Barsova Gabriela , Prokopakis Emmanuel , Chabolle Frédéric , Doulaptsi Maria , Bal Cengiz , Cingi Cemal
Published: November 2024

Objectives: The current study examined the effectiveness of Rhinapi, a hypertonic saline nasal spray with Anatolian propolis added, on allergic rhinitis (AR) symptoms in a European population. Methods: Four hundred and forty AR patients (251 males and 189 females) from various European centers were enrolled. Nasal examination, overall symptom scores, individual AR symptoms (nasal discharge, sneezing, nasal itching, and nasal obstruction), and quality of life (QoL) were assessed before and after 3 weeks of treatment with Rhinapi, the nasal spray made of hypertonic saline with Anatolian propolis added (Bee&You, Istanbul, Turkey). Results: Rhinapi nasal drop use was associated with a substantial decrease ( P < .05) in AR symptom ratings, including nasal discharge, sneezing, nasal itching, and nasal obstruction. QoL scores showed a significant improvement ( P < .05), and the spray also alleviated swelling and improved concha color ( P < .05). Conclusion: Rhinapi, Anatolian propolis–added hypertonic saline nasal spray (Bee&You, Istanbul, Turkey), when used for 3 weeks, reduced AR symptom scores and improved QoL. Both the concha color and the edema were also enhanced.
Commentary: Strengthening System Readiness for Health Interventions: Lessons for Implementing Interventions and Implementation Support in Low-And Middle-Income Countries
Authors: Chen Hongtu , Chuengsatiansup Komatra , Wong Dylan R. , Sihapark Siranee , Krisanaprakornkit Thawatchai , Wisetpholchai Bussabong , Tongsiri Sirinart , Hinton Ladson , Gallagher-Thompson Dolores , Wandersman Abraham , Marques Andrea H. , Lamont Andrea E. , Levkoff Sue E.
Published: November 2024

In low- and middle-income countries (LMICs), barriers such as low system readiness, contextual mismatches, and resource limitations impede effective implementation of evidence-based interventions. This commentary offers insights into overcoming these challenges with a case study of the PRISM project, designed to reduce behavioral and psychological symptoms of dementia in older adults living in Thailand. The case highlights how combining two evidence-based models - the Reducing Disability in Alzheimer’s Disease clinical intervention and the Getting To Outcomes implementation science process enhances program success. Using interviews with stakeholders across various health system levels, we identify factors critical to successful program implementation: (1) integrating interventions into policy frameworks, (2) empowering local implementers, (3) fostering collaborative learning, and (4) adapting interventions to local contexts. The case demonstrates that building system readiness through local engagement and ownership is central to scaling up health programs in LMICs. This commentary’s contribution lies in its emphasis on the role of implementation science as a vehicle for translating research into practice. It presents a practical, adaptive model for embedding interventions into routine health systems, thereby offering a pathway for successfully scaling up evidence-based programs in LMICs. Such findings provide lessons for overcoming barriers to implementation in resource-limited environments.
Efficient removal of ibuprofen from aqueous solutions using silica-based nanocomposites: A comparative study
Authors: Khalil Laila A. , Al-Jabari Mohammed H. , Sulaiman Saleh M.
Published: November 2024

This study investigates the efficacy of environmentally friendly silica-based nanocomposites, SiO2-Fe3O4 and SiO2-ZnO, for removing Ibuprofen (IBU) from aqueous solutions. The synthesized nanocomposites were characterized using various techniques, such as SEM, TEM, EDS, and FTIR. The adsorption capabilities of IBU onto these nanocomposites were explored through comparative analysis, focusing on factors such as pH, initial pollutant concentration, contact time, and temperature. Results reveal that the adsorption process is pH-dependent, and the lower pH levels enhance the adsorption process. The IBU removal process is faster with SiO2-Fe3O4 compared to SiO2-ZnO. Kinetic modeling suggests a pseudo-second-order mechanism [Formula: see text] for IBU adsorption onto the surfaces of both adsorbents. Langmuir and Freundlich isotherms were employed and demonstrated to analyze the equilibrium data. The Langmuir model revealed a higher maximum adsorption capacity for SiO2-Fe3O4 [Formula: see text] than SiO2-ZnO [Formula: see text]. Thermodynamic analysis indicates a chemisorption mechanism for SiO2-ZnO and a physisorption mechanism for IBU molecules on the surface of SiO2-Fe3O4. In addition, the standard thermodynamic parameters for the adsorption process indicate that IBU adsorption via both nanocomposites is exothermic, resulting in reduced entropy, and occurs spontaneously. This research introduces silica-based nanocomposites with Fe3O4 nanoparticles for efficient Ibuprofen removal from aqueous solution. The magnetic properties allow easy separation and reusability, enhancing treatment effectiveness. The study offers valuable insights for improving water treatment strategies with potential industrial applications.
The safety of cell saver washing all shed mediastinal blood before re-transfusing it to the patient
Authors: Scicluna Sara , Dencker Magnus , Bjursten Henrik
Published: November 2024

Introduction

Cardiotomy suction blood is used in cardiopulmonary bypass (CPB) surgery to maintain blood volume in the CPB system, although it is known to contain micro emboli, cytokines and free plasma hemoglobin. Our aim was to investigate whether cell saver washing the cardiotomy suction blood before re-transfusing it is safe.

Methods

This is a retrospective study of 1671 elective coronary artery bypass patients, 209 of whom had their pericardial blood processed in a cell saver (Ce-S group). PS matching was performed with patients who had their pericardial blood returned back to the CPB-system by the cardiotomy suction (Ca-S group). Perioperative transfusion requirements, surgical outcome, postoperative lab data and mortality were then compared.

Results

There were no differences in baseline characteristics or EuroSCORE between the groups. The number of patients requiring transfusions did not differ, but the patients in the Ca-S group received more platelets (0.34 ± 1.0 vs 0.16 ± 0.7 units, p = .03) than in the Ce-S group. CRP (c-reactive protein) levels at day 2 and 4 were higher in the Ca-S group (174.8 ± 67.2 and 148.9 ± 74.3 mg/L vs 160.1 ± 64.6 and 125.9 ± 67.2 mg/L, p = .03, p = .002) and so were ASAT (aspartate aminotransferase) levels (0.97 ± 0.8 vs 0.81 ± 0.6 μkat/L, p = .03). Mortality, postoperative ventilation time, stroke, mediastinal infections and length of stay in the ICU were the same in both groups.

Conclusions

In this retrospective study of patients undergoing elective CABG surgery, washing the cardiotomy suction blood before re-transfusion was not associated with higher risk of allogenic blood transfusion, postoperative stroke, mediastinal infections, or 30- and 365-days mortality.

Clinical registration number

LU EPN 2016/4.
An actuator space optimal kinematic path tracking framework for tendon-driven continuum robots: Theory, algorithm and validation
Authors: Qiu Ke , Zhang Hongye , Zhang Jingyu , Xiong Rong , Lu Haojian , Wang Yue
Published: November 2024

Path tracking of continuum robots is a fundamental and crucial problem across various applications. In this article, we address this problem by focussing on three aspects. Firstly, we propose an efficient multi-solution inverse kinematics solver for three-section constant curvature robots by bridging the theoretical reduction and the numerical correction. Secondly, we derive a linear tendon-driven actuation model, establishing the connection between the robot configuration space and the actuator space. With this model, we achieve optimal distance planning and optimal time allocation considering the constraints of actuator velocity and acceleration, generating a continuous trajectory directly in the actuator space. Finally, we present our kinematic path tracking framework, which includes offline optimal trajectory planning and online feedforward and feedback control. Experiments are conducted both in simulations and in the real world on our three-section tendon-driven continuum robot. The experiments validate the increased efficiency, higher success rates, and accessibility of multiple solutions offered by our inverse kinematics solver, as well as the optimality in distance planning and time allocation in the actuator space. Performance improvements in tracking accuracy are demonstrated through comparative experiments and the application of our framework in path tracking tasks with obstacles is presented through a case study.
Risk factors for positive cervical cytology during early pregnancy screening and awareness of positive cytological results in Japan: a report from the Pregnant Women Health Initiative
Authors: Ushio Emiko , Mizushima Taichi , Sukegawa Akiko , Saigusa Yusuke , Kurasawa Kentaro , Iwata Akiko , Aoki Shigeru , Ueda Yutaka , Sekine Masayuki , Miyagi Etsuko
Published: November 2024

Objective

Cervical cancer screening rates are low in Japan. Therefore, when a woman is pregnant, this is a good opportunity to visit an obstetrics and gynecology clinic to have cervical cytology. This study aimed to clarify the association between cervical cancer screening and the management of pregnant women’s health.

Methods

We prospectively examined the relationships between cervical cytological results during prenatal checkups and the following factors: participant’s background, cytological sampling instruments, and awareness of cytological results.

Results

Of the 2725 participants, 71 showed abnormal results defined as atypical squamous cells of undetermined significance or higher grade (ASC-US+). ASC-US+ detection rates were higher in smokers, younger participants, those with a low education, those without cancer screening in the past 2 years, and those who received cytology using a spatula or brush. A multivariable logistic regression analysis identified smoking (adjusted odds ratio: 2.99 [95% confidence interval: 1.41–6.33]) and a spatula/brush (adjusted odds ratio: 2.46 [95% confidence interval: 1.09–5.53]) as independent variables associated with detecting ASC-US+. Among the participants, 39.4% (28/71) self-reported “no abnormalities,” despite obtaining an ASC-US+ result.

Conclusions

Pre-pregnancy smoking and cytological sampling tools may contribute to detecting ASC-US+. Patients with detected abnormalities need accurate information and reliable follow-up.