bluuebunny/crossref_metadata_2025 huggingface dataset:
Rheumatoid Arthritis and Pla2r-associated Mebranous Nephropathy . Cause or Coincidence?
Authors: Perea-Ortega Lara , Muñoz-Sánchez Ana , León-Fradejas Myriam , Toledo-Rojas Remedios , López-Jiménez Verónica
Published: July 2024

Background: Rheumatoid arthritis affects 0.5% of adults in our country. It is an inflammatory disease that predominantly affects the joints causing destruction of the articular cartilage. Approximately 50% of patients present with extra-articular manifestations. Renal involvement is relatively frequent and clinically significant because it worsens the course and mortality of the primary disease. The histological renal damage observed in such patients includes a wide variety of entities and histological patterns with both glomerular and tubulointerstitial involvement, with secondary membranous nephropathy being one of the most common. Coexistence with primary membranous nephropathy is rare.
Case Presentation: A 46-year-old man recently diagnosed with rheumatoid arthritis was referred to the nephrology department for deterioration of renal function and subnephrotic proteinuria. The autoimmune study showed positive anti-PLA2R. Due to the unusual association between both entities, it was decided to perform a renal biopsy which showed abundant spikes. The immunofluorescence study showed contiguous parietal IgG positivity (3+). Immunohistochemistry showed positive granular IgG4, confirming the diagnosis of PLA2R-associated membranous nephropathy.
Conclusions: Membranous nephropathy is one of the most common causes of nephrotic syndrome in adults. The determination of anti-PLA2R has been a great advance in the rapid differential diagnosis of MN. In recent years, new target antigens associated with certain underlying pathologies have been discovered. However, PLA2R is not associated with any disease or exposure and therefore remains the antigen responsible for 80% of primary NMs. Anti-PLA2R antibodies can be produced by loss of central or peripheral tolerance. Whether these mechanisms are triggered by rheumatoid arthritis itself is difficult to prove. The cytokine TNF-like weak inducer of apoptosis (TWEAK) has been associated with rheumatoid arthritis. This proinflammatory molecule increases the expression of PLA2R in podocytes, sensitising them to the damaging action of anti-PLA2Rs, which could justify a causal relationship between the two pathologies. Treatment should be tailored to the individual risk profile for progression. Rituximab could be an optimal option for both entities.
CryoCycle your grids: Plunge vitrifying and reusing clipped grids to advance cryoEM democratization
Authors: Noble Alex , Serbynovskyi Viacheslav , Wang Jing , Chua Eugene , Ishemgulova Aygul , Alink Lambertus , Budell William , Johnston Jake , Dubbeldam Charlie , Gonzalez Fabio , Rozovsky Sharon , Eng Edward , de Marco Alex
Published: July 2024

CryoEM democratization is hampered by access to costly plunge-freezing supplies. We introduce methods, called CryoCycle, for reliably blotting, vitrifying, and reusing clipped cryoEM grids. We demonstrate that vitreous ice may be produced by plunging clipped grids with purified proteins into liquid ethane and that clipped grids may be reused several times for different protein samples. Furthermore, we demonstrate the vitrification of thin areas of cells prepared on gold-coated, pre-clipped grids.
RILEM TC-275 (HDB): Presentation of TC HDB and mechanical performances of hemp concrete of the specimen of the round robin test
Authors: Amziane Sofiane , Toussaint Evelyne , Collet Florence
Published: July 2024

This study delves into the mechanical performance of hemp concrete – a sustainable construction material – with a focus on how the orientation of the hemp shiv affects its mechanical properties. Employing uniaxial compression testing and advanced Digital Image Correlation (DIC) techniques for surface deformation analysis, the research examines specimens in which the shiv particles are aligned perpendicular and parallel to the load direction. Results indicate significant variability in mechanical behavior – perpendicular specimens demonstrate a clear stiffening phase up to 3% strain before deterioration, whereas parallel specimens lack distinct phases. Moreover, DIC measurements suggest hemp concrete has higher Young's moduli and Poisson's ratios compared to traditional materials, and they underline considerable strain localization, especially at aggregate boundaries in parallel specimens. The DIC analysis provides a deeper understanding of the heterogeneous strain distribution, highlighting the interfacial transition zone's influence on the material's mechanical characteristics. These insights are pivotal for optimizing the use of hemp concrete in sustainable building design.
E-pro Within a Comprehensive Companion Program (Ccp) to Reduce Emergency Visits (Erv) and Inpatient Admission (Nia) in a Peruvian Institution
Authors: Rioja Patricia , Ruiz Rossana , Araujo Jhajaira , Macetas Jackeline , Acevedo Sandra , Guevara Tania , Quesquen Mercedes , Young Frank , Montenegro Paola
Published: July 2024

PURPOSE: To describe the implementation process of the CCP and demonstrate their impact in terms of ERV and NIA. METHODS: The CCP was designed as a remote web-based where patients could find information about their diagnosis, treatment and adverse symptoms. An e-PRO questionnaire was developed. The impact was examined for: ERV and NIA through a cohort analysis of patients with gastrointestinal (GI) cancer receiving systemic treatment at Oncosalud-AUNA between June 2021- July 2022. The cohorts were: 1) patients who enrolled into the CCP and 2) otherwise eligible patients not enrolled into CCP. Incidence rate (IR), IR ratios (IRR) and 95% confidence intervals were calculated. Time to first ERV and NIA curves were constructed using the Kaplan Meier method and log rank test.
RESULTS: 199 participants, 97 enrolled into CCP. Median age was 61 years (30 - 92 years). 51.5% of patients was EGOG 0-1. Chemotherapy was the most common treatment (88.4%). The mean follow time was of 8.3 and 6.7 months, for patients in CCP and not, respectively. ERV IR was 15.1 per month for patients enrolled into the CCP (95%CI: 12.6-18.0) vs. 20.3 per month for patients not enrolled (95% CI: 17.0-24.0) which translated into a 25% decrease in ERV (IRR: 0.75 (95%CI: 0.58-0.96; p=0.02)). NIA IR was 5.9 per month for patients enrolled into the CCP (95%CI: 4.4-7.8) vs. 9.2 per month for patients not enrolled (95%CI: 7.0-11.8) which translated into a 35% decrease in NIA (IRR: 0.65 (95%CI: 0.44-0.96; p=0.02)).
CONCLUSIONS: Our study demonstrates the feasibility of the CCP in our reality and the impact that it has reducing the utilization of other healthcare services.
ATG5 gene delivery by rAAV9 promotes doxorubicin-induced atrial fibrillation and structural remodeling
Authors: Xie Xin , Li Ya-Nuo , Wang Shi-Hao , Xu Yong , Kang Ze-Chun , Luan Hai-Yun , Liu Jie , Xu Nuo , Shen Zheng , Bian Wei-Hua
Published: July 2024

Doxorubicin (DOX) is used as first-line chemotherapeutic drug in treating various cancers. However, patients with DOX administration are susceptible to atrial fibrillation (AF) with unknown mechanisms. Numerous previous studies have shown that autophagy plays an important role in the development of AF, but autophagy protein 5 (ATG5) in DOX-induced AF has still not been studied. Mice were intraperitoneally injected with DOX (5mg/kg) for 4 weeks to establish AF model. AF was documented by telemetry in vivo, the atria were assessed for molecular biological and morphological analyses. HL-1 cells were treated with DOX, then autophagy flux and oxidative stress were detected by confocal microscopy and DCF-DA staining. Here, we found that autophagy related genes including ATG5, Beclin-1, ATG12 and LC3B were upregulated in DOX-treated HL-1 cells. DOX treatment resulted in AF, atrial fibrosis and oxidative stress in mice, which were mitigated by rAAV9 expressing shRNA-ATG5 and aggravated by rAAV9 expressing ATG5. In addition, DOX treatment increased autophagosome but blocked autophagic flux, increased ROS generation and induced oxidative stress in HL-1 cells. These effects were markedly attenuated by siRNA-ATG5, whereas aggravated by adenovirus expressing ATG5 in HL-1 cells. Mechanically, we found DOX caused AF through ATG5-mediated autophagy which further regulated oxidative stress and atrial fibrosis. Overall, our study demonstrated that ATG5-mediated autophagy aggravated DOX–induced AF.
Characteristics and Trends in Adverse Drug Reactions in Ghana- Evidence of Spontaneous Reports, 2005-2021
Authors: Nyame Linda , Xue Hui , Yu Jinxia , Fiagbey Emmanuel D.K , Thomford Kwesi Prah , Du Wei
Published: July 2024

Purpose Adverse drug reaction (ADR) monitoring is crucial in ensuring patient and pharmaceutical safety. However, there is lack of evidence regarding the trend pattern of ADR reports in Ghana. We therefore, aimed to analyse and characterize trends in ADRs reported in Ghana over 16 years.
Methods We retrospectively analysed ADR reports received by the Ghana National Pharmacovigilance Centre from 2005 to 2021. Jointpoint regression was used to estimate age-adjusted ADR rates, stratified by sex and patient characteristics, suspected medication groups, clinical indications and the manifestation of ADRs. To evaluate trends over time, the percentage annualised estimator was used.
Results We identified a total of 6,189 ADR reports from 2005 to 2021. The age-adjusted ADR report rates increased significantly from 2005–2019, with an annual increase of 18.6%, however, there was a downward trend from 2019–2021, although not statistically significant. Males accounted for the majority (64.3%) of ADR reports compared to females (35.7%). The medication group most frequently associated with ADRs were antiprotozoals accounting for 35.6% of all ADR reports while vascular disorders (21.0%) were the most commonly observed clinical indication in relation to ADRs. An increase in ADR report rates was noted for infections and infestation with an annual increase of 22.4% (95% CI: 9.7–36.7%; p < 0.001).
Conclusion ADRs significantly contribute to health problems in Ghana, with an increasing trend of ADR-related medication use. The findings of this study call for multifaceted strategies aimed at reducing the risks associated with drug use, thus improving patient safety.
Preparation and characterization of plant protein-mushroom hybrids: Toward more healthy and sustainable foods
Authors: Jayakumar Disha , Santhapur Ramdattu , McClements David Julian
Published: July 2024

There is growing interest in finding more sustainable alternatives to animal-derived foods, like meat, fish, egg, and dairy products. This study focusses on the formation and properties of hybrid protein-rich foods consisting of potato protein and mushroom, specifically Oyster (Pleurotus ostreatus) and Shiitake (Lentinula edodes) mushrooms. Hybrid products with the same total solids content (20% w/w) were formed by combining potato protein (10% or 15% w/w) with powdered mushroom (10% or 5% w/w) in aqueous solutions (100 mM NaCl). Measurements of the z-potential versus pH profile showed that the electrical charge of both the proteins and mushrooms went from positive at pH 3 to negative at pH 8, but the point of zero charge was around pH 5.0, 4.0, and 3.5 for potato protein, Oyster mushroom, and Shitake mushroom, respectively. Consequently, there were intermediate pH conditions where there should be an electrostatic attraction between the proteins and mushrooms. Differential scanning calorimetry showed that the potato proteins were originally in their native state but underwent irreversible thermal denaturation around 66 oC, whereas the mushroom dispersions exhibited no thermal transitions. Thermal denaturation of the potato proteins was still observed in the presence of mushrooms. The potato protein was soluble at low and high pH values, but insoluble around its isoelectric point (pI 5). In contrast, the mushroom dispersions contained insoluble particles across the entire pH range. The protein-mushroom hybrids were heated at 90°C for 30 minutes to promote thermal denaturation and gelation of the proteins. Texture profile analysis showed that the hybrids were harder and chewier than protein alone, especially when shiitake mushrooms were added, making them more meat-like. Dynamic shear rheology showed that strong irreversible heat-set gels were formed when the proteins were thermally denatured. Tristimulus color analysis showed that the L*, a*, and b* values changed upon adding the mushrooms, leading to a browner appearance. Microscopy analysis showed that the hybrids had a heterogeneous microstructure, which was attributed to the dispersion of insoluble mushroom particles in a potato protein matrix. These results suggest that potato protein and mushroom hybrids could be healthy, eco-friendly, and tasty substitutes for meat, but further research is required on their nutritional and sensory attributes.
The prevalence and determinants of unplanned pregnancy among pregnant women attending antenatal clinic in the primary health care centers at KAMC- Jeddah
Authors: Wali Razaz Mohammed
Published: July 2024

Background Unplanned or unintended pregnancy is one of the major health issues globally and regionally. It poses many health, psychological, and financial impacts on the individual and the health care system. Some determinants can affect women's decision to become pregnant; tackling these determinants can give policymakers a better understanding of the current health issue and help them develop recommendations accordingly.
This study aimed to identify the prevalence and determinants of unplanned pregnancy in pregnant women visiting antenatal clinics in primary health care centers in the western region of Saudi Arabia from September 2022 to July 2023.
Methods An analytic cross-sectional study was conducted in Jeddah from September 2022 to July 2023. A convenient nonprobability sampling method was used to recruit 346 pregnant women who were booked in primary health care antenatal clinics; the data were collected using the modified Arabic version of the London Measure of Unplanned Pregnancy (LMUP). The questionnaire data were analyzed using the Statistical Package for Social Science (SPSS) version 22.
Results The prevalence of unplanned pregnancy among the study population was 17.6%. There was a significant association between unplanned pregnancy and the duration between the last two pregnancies, having thoughts and actions to terminate the pregnancy, and meeting the women's contraceptive needs.
Conclusion Unplanned pregnancy is prevalent among pregnant women attending antenatal clinics in primary health care centers at KAMC in the western province of Saudi Arabia but is less common in this region than in other parts of the world. Multiple risk factors can determine the risk of unplanned pregnancy, including women's education, family income, and ability to meet contraceptive needs. Public health personnel can use these indicators to understand population fertility and women's health services and reduce the rate of unplanned pregnancies, a key objective for the health care system in Saudi Arabia.
Chromium-methionine chelate can reduce protein content in Nile tilapia diets: an analysis of growth, carcass, biochemical and hematological parameters, and economic return
Authors: Oliveira Crislaine Palmeira Barbosa , Copatti Carlos Eduardo , Lemos Carlos Henrique Paixão , Couto Ricardo David , Figueiredo-Silva Claudia , Silva Janilson Felix , Vidal Luiz Vitor Oliveira
Published: June 2024

This study aimed to evaluate the effects of adding chromium-methionine (Cr-meth) chelate in extruded diets containing reduced protein content on growth performance, carcass composition, nutrient retention, and hematobiochemical responses in Nile tilapia juveniles. The fish were fed with two control diets (no Cr-meth): positive control (311 g kg-1 of crude protein, estimated 258 g kg-1 of digestible protein) and negative control (255 g kg-1 of crude protein, estimated 207 g kg-1 of digestible protein). Another five experimental diets (mean 251 g kg-1 of crude protein, mean estimated 204 g kg-1 of digestible protein) were supplemented with 0.2, 0.4, 0.6, 0.8, and 1.0 mg Cr-meth kg diet−1. Juveniles (34.31 g) were organized in a randomized design (seven treatments in triplicate) in 21 tanks (250 L) and fed until apparent satiety. The experiment lasted nine weeks. Fish fed 0.8 and 1.0 mg Cr-meth kg diet−1 showed zootechnical variables similar to the positive control. The reduced protein diets showed lower costs, and supplementation with 0.91 mg kg-1 of chromium matched the profitability observed in the positive control diet. Carcass gross energy and energy retention, plasma cholesterol (total and LDL), and triglycerides values were higher in fish fed 0.6 mg Cr-meth kg diet−1 than in the positive control. Treatments with dietary Cr-meth (mainly between 0.4 and 0.8 mg kg−1) decreased carcass Cr, selenium, and copper retention and increased carcass nitrogen retention and muscle glycogen levels compared to the positive control. This treatment (positive control) also had lower values for total leukocytes and monocytes, respectively, than fish fed 0.2 and 0.4 mg Cr-meth kg diet−1 and for eosinophils and lymphocytes than fish fed 0.8 mg Cr-meth kg diet−1. In conclusion, we recommend supplementation with 0.8 mg Cr-meth kg diet−1 for diets with low protein content, as it produces a dietary protein-sparing effect, reducing costs, improving immune defense, muscle glycogen, and nitrogen retention without compromising growth performance, physiology, and fish metabolism.
The Effect of Testing Rate on Biomechanical Measurements Related to Stalk Lodging
Authors: Tabaraccci Kaitlin , Vos Jacques , Robertson Daniel
Published: July 2024

Background
Stalk lodging (the premature breaking of plant stalks or stems prior to harvest) is a persistent agricultural problem that causes billions of dollars in lost yield every year. Three-point bending tests, and rind puncture tests are common biomechanical measurements utilized to investigate crops susceptibility to lodging. However, the effect of testing rate on these biomechanical measurements is not well understood. In general, biological specimens (including plant stems) are well known to exhibit viscoelastic mechanical properties, thus their mechanical response is dependent upon the rate at which they are deflected. However, there is very little information in the literature regarding the effect of testing rate (aka displacement rate) on flexural stiffness, bending strength and rind puncture measurements of plant stems.
Results
Fully mature and senesced maize stems and wheat stems were tested in three-point bending at various rates. Maize stems were also subjected to rind penetration tests at various rates. Testing rate had a small effect on flexural stiffness and bending strength calculations obtained from three-point bending tests. Rind puncture measurements exhibited strong rate dependent effects. As puncture rate increased, puncture force decreased. This was unexpected as viscoelastic materials typically show an increase in resistive force when rate is increased.
Conclusions
Testing rate influenced three-point bending test results and rind puncture measurements of fully mature and dry plant stems. In green stems these effects are expected to be even larger. When conducting biomechanical tests of plant stems it is important to utilize consistent span lengths and displacement rates within a study. Ideally samples should be tested at a rate similar to what they would experience in-vivo.
A Novel Peptide HIF9-nano Complex Targeting Apoptosis
Authors: Manimaran Dharmar , Palanisamy Vasan , Rangasamy Kowsalya , Elangovan Namasivayam
Published: July 2024

In cancer therapy, cell proliferation can activate apoptotic machinery in the cell to suppress tumor growth. Though, the number of malignant cells does not effectively regulate the expression of vital genes that play a crucial role in the process of apoptosis in order to control. However, many malignant cells cannot regulate the genes that control apoptosis. Various intracellular and extracellular signals activate the process of apoptosis. The present investigation evaluated the anticancer effect of Peptide Chitosan Nanoparticles - M04 (PCN-M04) in the breast cancer cell line. PCN-M04 has a strong antiproliferative impact on breast cancer cells (MCF-7), indicating that it suppresses cancer cell growth in a dose-dependent manner. In order to assess the mode of cell death after treatment of PCN-M04 on breast cancer cells, various assays such as intracellular ROS formation, DNA fragmentation assay, Comet Assay and Mitochondrial membrane potential were performed. In addition, both gene and protein expression analyses were carried out by RT-PCR and Western blot analysis. The results suggested that PCN-M04 inhibits cell proliferation in MCF-7 cells in a dose-dependent manner. After 24 hrs treatment, PCN-M04 significantly elevates the ROS generation and effectively alters the mitochondrial membrane potential. The DNA fragment assay and comet assay results clearly depicted the DNA damage and nuclear fragmentation. Further, PCN-M04 significantly controls the expression of anti-apoptotic protein Bcl-2, increased Bax and subsequently leads to the elevation of apoptotic inducing protein p53 that releases from mitochondria and activates the other apoptotic inducing proteins such as Caspase-9 and 3. The overall results of the current study clearly indicated that PCN-M04 effectively induced the oxidative stress-mediated mitochondrial signaling mechanism by which it induces cell death. Hence, the novel peptide-based nanoformulation (PCN-M04) could be a potent therapeutic agent to inhibit or treat breast cancer.
Enhancing Semantic Scene Segmentation for Indoor Autonomous Systems Using Advanced Attention-Supported Improved UNet
Authors: Ngoc Hoang Tran , Vinh Nghi Nguyen , Le Nhi Quynh Phan , Nguyen Nam Nhat Ngo , Le Thu Anh Nguyen , Dinh Vinh Nguyen
Published: July 2024

This paper introduces EFFB7-UNet, an advanced semantic segmentation framework tailored for Indoor Autonomous Vision Systems (IAVSs) utilizing the U-Net architecture. The framework employs EfficientNetB4 as its encoder, significantly enhancing feature extraction. It integrates a spatial and channel Squeeze-and-Excitation (scSE) attention block, emphasizing critical areas and features to refine segmentation outcomes. Comprehensive evaluations using the NYUv2 Dataset and various augmented datasets were conducted. This study systematically compares EFFB7-UNet's performance with multiple U-Net encoders, including ResNet50, ResNet101, MobileNet V2, VGG16, VGG19, and EfficientNets B0-B6. The findings reveal that EFFB7-UNet not only surpasses these configurations in terms of accuracy but also highlights the effectiveness of the scSE attention block in achieving superior segmentation results. Without utilizing depth information, EFFB7-UNet achieves a 12\% improvement in mean Intersection over Union (mIOU). This notable enhancement highlights EFFB7-UNet's adaptability across different domains, implying substantial progress in enhancing the effectiveness and reliability of Intelligent Autonomous Vision Systems (IAVS) technologies.
Contribution of leukocyte telomere length to major cardiovascular diseases onset: insights from a large-scale genome-wide cross-trait analysis
Authors: Pauklin Siim , Qiao Jun , Wang Qian , Zhao Yuhui , Chang Minjing , Cai Liuyang , Liu Feng , Yao Kaixin , Zheng Leilei , Tan Ning , He Pengcheng , Jegga Anil , Jiang Lei , Yang Yining , Feng Yuliang
Published: July 2024

Telomere shortening, a marker of cellular aging and genomic instability, has been epidemiologically linked to an increased risk of various cardiovascular diseases (CVDs). However, shared genetic determinants involved in these associations remain unclear. We composed an atlas of the shared genetic associations between leukocyte telomere length (LTL) and six major CVDs by investigating shared genetic elements, encompassing SNPs, genes, biological pathways, and protein targets with pleiotropic implications. Extensive genetic overlaps beyond genetic correlations were observed, but no causal relationships were established. We identified 248 independent pleiotropic genomic risk loci, implicating 50 unique genes in two or more trait pairs, especially the SH2B3 gene, which was further validated by a proteome-wide Mendelian Randomization study. Functional analysis demonstrated a link to both DNA biosynthetic processes and telomere maintenance mechanisms. These findings suggest a genetic link between LTL and CVDs, highlighting a shared genetic basis crucial for developing future interventions and therapeutic targets.
LINC01354 affect glioma survival
Authors: Xu Jingxuan
Published: July 2024

Background
Gliomas are the most prevalent primary malignant brain tumors worldwide. Recent studies highlight the potential of long non-coding RNAs (lncRNAs) in tumor progression, with LINC01354 being upregulated in various malignancies. This study investigates the role of LINC01354 in glioma prognosis to provide novel insights for early prognosis prediction.
Methods
This study involved four cohorts of low-grade glioma tissue samples collected from hospitals in Xinjiang, Beijing, and Guangzhou, China. Quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) was used to measure LINC01354 expression levels. Clinical information and survival data were analyzed using Cox regression and ROC analysis to evaluate the association between LINC01354 expression and overall survival. Clinical comparisons were conducted to identify potential discrepancies in clinical parameters across different cohorts.
Results
Elevated LINC01354 levels were associated with poorer overall survival in the West China cohort (Xinjiang) but not in the North (Beijing) or South China (Guangzhou) cohorts. Clinical parameter comparisons revealed no significant differences among the cohorts that could explain the regional discrepancy. Further analysis within the West China cohort indicated that LINC01354's prognostic value was consistent across Han and non-Han ethnic groups and unaffected by dietary staples. However, LINC01354's prognostic significance was more pronounced in patients born in Xinjiang compared to those born elsewhere. A prognostic model incorporating LINC01354 expression and birth location demonstrated good predictive accuracy with ROC AUC values of 0.777 in the training cohort and 0.757 in the validation cohort.
Conclusion
LINC01354 is a potential prognostic biomarker for low-grade glioma in the West China population, particularly among patients born in Xinjiang.
Returning CP-observables to the frames they belong
Authors: Ackerschott Jona , Barman Rahool Kumar , Gonçalves Dorival , Heimel Theo , Plehn Tilman
Published: July 2024

Optimal kinematic observables are often defined in specific frames and then approximated at the reconstruction level. We show how multi-dimensional unfolding methods allow us to reconstruct these observables in their proper rest frame and in a probabilistically faithful way. We illustrate our approach with a measurement of a CP-phase in the top Yukawa coupling. Our method makes use of key advantages of generative unfolding, but as a constructed observable it fits into standard LHC analysis frameworks.
Celestial sector in CFT: Conformally soft symmetries
Authors: Pipolo de Gioia Leonardo , Raclariu Ana Maria
Published: July 2024

We show that time intervals of width \Delta \tauΔτ in 3-dimensional conformal field theories (CFT_33) on the Lorentzian cylinder admit an infinite dimensional symmetry enhancement in the limit \Delta \tau → 0Δτ→0. The associated vector fields are approximate solutions to the conformal Killing equations in the strip labelled by a function and a conformal Killing vector on the sphere. An Inonu-Wigner contraction yields a set of symmetry generators obeying the extended BMS_44 algebra. We analyze the shadow stress tensor Ward identities in CFT_dd on the Lorentzian cylinder with all operator insertions in infinitesimal time intervals separated by \piπ. We demonstrate that both the leading and subleading conformally soft graviton theorems in (d-1)(d−1)-dimensional celestial CFT (CCFT_{d-1}d−1) can be recovered from the transverse traceless components of these Ward identities in the limit \Delta \tau → 0Δτ→0. A similar construction allows for the leading conformally soft gluon theorem in CCFT_{d-1}d−1 to be recovered from shadow current Ward identities in CFT_dd.
Implementation of eco-control system by Indonesian manufacturing firms: Understanding the mediating role of organizational culture
Authors: Try Dharsana Muhammad , Iqra Pradipta Natsir Andi , Indra Hermansyah Fakhrul , Nur Fatimah Syahnur Khaerunnisa
Published: July 2024

Implementing eco-control is a strategic way for companies to prevent environmental damage. This paper aims to analyze the effect of perceived environmental uncertainty and stakeholder pressure on system implementation through environmentally oriented organizational culture as a mediating variable. This study utilizes the PLS-SEM model using a sample of 104 manufacturing companies in Indonesia; 197 respondents from those companies completed the survey. All variables used in the research model are significant for a formative measurement model, and an internal model applied met all criteria. This study confirms a negative relationship between perceptions of environmental uncertainty and environmentally oriented organizational culture (β = 0.174, p < 0.01). The opposite effect is shown by the relationship between stakeholder pressure and organizational culture (β = 0.379, p < 0.01), and the positive effect of organizational culture on the implementation of eco-control in companies is significant (β = 0.650, p < 0.01). In addition, organizational culture partially mediates the relationship between perceptions of environmental uncertainty and the implementation of the eco-control system (β = 0.317, p < 0.05) and between stakeholder pressure and the implementation of this system (β = 0.401, p < 0.05). When companies through managers face uncertainty from the ecological environment and stakeholder pressure, they should utilize an eco-control system, which can succeed in profit goals and environmental responsibility.
Hubungan Bermain Peran Dalam Pembelajaran Daring Dengan Tingkat Perkembangan Sosial Emosional Anak Usia Dini
Authors: Suprayogi Muhamad Nanang , Soeriaatmadja Alya Fadia
Published: June 2024

This study aims to examine the relationship between role play in online learning and the socio-emotional development level of early childhood. This study uses a quantitative method with 76 respondents from kindergarten and early childhood education teachers in DKI Jakarta. In measuring dramatic play, this study adapts Smilansky's Scale for the Evaluation of Dramatic and Socio-dramatic Play measuring instrument and in measuring social emotional development adapts the Social-emotional development assessment. The data obtained in this study are based on the results of respondents' observations. The results of this study found that there was a significant and positive relationship between role playing and social emotional development level. This is based on the results of the correlation coefficient analysis (r = 0.570, p < 0.05) and the linearity analysis of the scatter plot spreads diagonally on the graph. The result of the study suggests that the teacher can use the role-playing for increasing the development of social-emotional among early childhood.
Digital Marketing: A Case Study of Social Media Marketing of Indonesia Real Estate Companies
Authors: Widjaja Herman , Santoso Handri
Published: June 2024

Real Estate industry, like other industries, is also heavily influenced by digital marketing especially the social media. Websites, Facebook, Instagram and YouTube become necessity in modern marketing of real estate. Indonesia’s real estate industry is a dynamic industry considering the country’s economy growth, population size and growth. Although several research has been conducted in this area, the topic focusing on Indonesia’s real estate Social Media Management System (SMMS) is still very limited. The qualitative comparative study is intended to explore and compare social media marketing strategy among top developers in Indonesia, and how they utilize the platforms to distribute marketing content and company’s other information. The data are collected from observation of the companies’ official websites and 138 accounts in YouTube, Facebook and Instagram. The study shows that each company has different strategy, depends on project locations, product / project size, project / product lifetime, target audience (prospects, affiliates, public in general, community etc), project’s ownership structure (fully owned, joint venture, franchise), sales / recurring / operational, management of social media team. Among the surveyed platforms, Instagram has been the most popular to distribute sales information for either recurring products, sales products group of products and even corporate or general public information.
The effect of silicone oil on the anatomical and functional parameters of the retina during surgery of regmatogenic retinal detachment
Authors: Neroev V. V. , Zaytseva O. V. , Ushakov A. I.
Published: July 2024

Vitrectomy followed by endotamponade of the vitreal cavity with silicone oil (SO) is one of the main techniques of treating severe forms of regmatogenic retinal detachment (RRD). Endotamponade with SO, having numerous advantages and a huge potential, carries the risk of a number of complications arising at various times of application. The literature review analyzes the published data on the effect of tamponade SO on the retina and the function of central vision in RRD surgery: visual acuity, indicators of light and color sensitivity, data of electrophysiological test results. Possible causes of deteriorated central vision functions directly or indirectly related to tamponade with SO are discussed: changes in the thickness and structure of the retina or its individual layers as shown by optical coherence tomography (OCT) data, microcirculation disorders according to OCT angiography, fluorescein angiography, Doppler laser scanning, as well as pathohistological findings related to SO migration into the fundus of eye tissues.
Endothelial keratoplasty in integrity-damaged iridolenticular diaphragm
Authors: Tereshchenko A. V. , Demyanchenko S. K. , Erina Yu. D. , Pashtaev A. N. , Katmakov K. I. , Trifanenkova Y. M. , Gelyastanov A. M. , Lugovaya A. A.
Published: July 2024

The review presents methods for performing endothelial keratoplasty (EK) in patients with endothelial corneal dysfunction, combined with discontinuities of the iridolenticular diaphragm as reflected in the PubMed, Scopus and eLibrary reference databases for the period ending in 2022. EK performed according to a variety of techniques allows achieving good clinical and functional results and reducing the risk of complications at different stages of treatment of patients with endothelial insufficiency. Another important advantage of EK as compared to penetrating keratoplasty is the fact that it can be repeated multiple times, which is relevant for patients with severe combined pathologies. Considering the plethora of modifications of posterior lamellar keratoplasty and transplantation of the Descemet's membrane and endothelium for cases with combined damages of the integrity of the iridolenticular diaphragm, the number of affected patients may be even more numerous than presented in the publications reviewed. The variety of literature data shows that the search for a universal technique of EK to be performed on patients with various disorders of the iridolenticular diaphragm is likely to continue.
A spectrofluorimetric method of testing a transplanted pedicle skin flap in eyelid neoplasm surgery
Authors: Garkavenko V. V. , Salmin V. V. , Balashova P. M. , Epova E. V.
Published: July 2024

Purpose: to develop a method for assessing metabolic changes in pedicle skin flaps using spectrofluorimetry in eyelid neoplasm surgery. Material and methods. 14 patients (mean age 74.50 ± 7.14 years) were operated for eyelid neoplasms with tissue defects replaced by pedicle flaps. The area of eyelid lesion achieved 90 %. In 100 % of cases, a histological examination revealed basal cell carcinoma. Metabolic changes of the skin in the transplanted flap and in the symmetrical area of the fellow eye were assessed using the spectrofluorimetric method 3 days and 3 months after the surgery. A number of successive spectra of fluorimetric parameters were taken from each site, whereupon the mean values of the Metabolic Shift Index were calculated. Results. Differences in the spectrofluorimetric parameters of the metabolic shift between the area with the transplanted flap and the symmetrical area were revealed on the third day after surgery (p = 0.00058) and 3 months after it (p = 0.0317). The obtained results indicate a partial preservation of the hypoxic state of the skin on the third postoperative day and the complete restoration of trophism 3 months after the surgery (p = 0.043), as well as the onset of scarring of the transplanted flap by the latter time point. Conclusion. A technique for assessing metabolic changes in eyelid skin has been developed, which enabled the establishment of normal spectrofluorimetric values in this area and helped reveal the changes in the indices of metabolic shift in the transplanted pedicle flaps in the early postoperative periods and throughout the entire follow-up period. 3 months after the surgical treatment, the indices of metabolic changes in the transplanted pedicle flap come close to normal values.
Ways to improve the effectiveness of glaucoma filtering surgery
Authors: Nikolaenko V. P. , Antonova A. V. , Brzhesky V. V.
Published: July 2024

The article presents a variety of ways to increase the efficiency of glaucoma filtering surgery. Special attention is given to maintaining the ocular surface healthy through optimal glaucoma therapy. The duration of the disease should be taken into account when choosing the type of hypotensive surgery and designing an algorithm for its pharmacological support: preoperative preparation, prolonged postoperative anti-inflammatory treatment and cornea protection.
Risk factors for functional state deterioration in patients with lymphatic malformation occuring in the neck region
Authors: Polev G. A. , Grachev N. S. , Oganesyan R. S. , Yaremenko E. Yu.
Published: July 2024

Introduction. The improvement and prediction of functional status in patients with lymphatic malformations of the head and neck, particularly in neck masses, remains a pressing socio-economic concern. As of the publication of this article, no comprehensive scientific studies have explored the cause-and-effect relationships that impact the functional status of this specific patient demographic.

Aim. To elucidate the cause-and-effect relationships impacting the functional status of patients with cervical lymphatic malformations and to develop a predictive model for their functional decline.

Materials and methods. A retrospective cohort study was conducted, involving a detailed analysis of the functional status of 115 paediatric and adolescent patients aged 1 month to 17 years, treated for cervical lymphatic malformations at the Dmitry Rogachev National Medical Research Center for Pediatric Hematology, Oncology, and Immunology, from May 2012 to December 2022. The analysis utilised the Cologne Disease Score (CDS), varying according to the histological type of the lymphatic malformations (microcystic, macrocystic, or mixed) and the staging of the de Serres classification.

Results and discussion. The study involved 115 patients with a median age of 2.1 years (ranging from 0.4 to 5.5 years). It was determined that the ‘Mixed lymphatic malformations type,’ ‘Stage V of the de Serres classification,’ and ‘Need for surgical treatment’ were clinically and statistically significant prognostic factors for the deterioration of functional status in these patients, reducing the CDS scores by 0.976 to 4.514 points, respectively. These findings supported the development of a predictive model for worsening functional status in this group.

Conclusion. The predictive model formulated during this research accounts for the histological type, location, and treatment modality, and is recommended for clinical application within specialised medical institutions.
Autonomia, geopolítica crítica e decolonialidade
Authors: Albuquerque Silva Carolina
Published: June 2024

Este artigo aborda a dimensão epistemológica da integração e do regionalismo na América Latina, com foco na ideia de autonomia e nas novas contribuições que as ciências sociais trazem a este debate. Baseia-se, para tanto, na abordagem de Jaime Preciado, que articula geopolítica crítica e decolonialidade na reflexão sobre os obstáculos e potencialidades de uma integração autônoma latino-americana na ordem mundial contemporânea. A argumentação realizada tem como conclusão a importância de incluir as dimensões sociais e epistemológicas às visões tradicionais da autonomia que a situam como assunto eminentemente estatal, tendo a América Latina como lugar de enunciação.
Política Externa e Agronegócio no Brasil
Authors: Nanci Izidro Gonçalves Fernanda Cristina , Morrot Coelho Madureira Eduardo
Published: June 2024

O artigo tem como objetivo discutir a atuação do agronegócio na política externa brasileira. Por meio do referencial teórico da Análise de Política Externa (APE), apresenta-se quem são os principais atores do agronegócio e quais são os seus interesses. Em seguida, realiza-se um estudo de caso do setor, observando sua atuação no governo Bolsonaro sobre três temáticas da agenda externa. Conclui-se que o agronegócio atua em concertação política por meio de diversas entidades ruralistas e que sua influência teve um efeito moderador sobre a política externa ideológica do governo Bolsonaro.
“Outro mundo é possível”
Authors: Granda Henao Daniel Sebastián
Published: June 2024

Seria possível pensar sobre o campo disciplinar pela ótica das cosmopolíticas insurgentes dos povos indígenas contra o Estado, o Capitalismo e o Patriarcado? Neste trabalho considera-se o pensamento e práxis do movimento neo-zapatista e procura-se uma possível chave de interpretação dessa meta-teoria como um discurso sobre as relações internacionais de outra perspectiva. O trabalho faz então uma revisão bibliográfica e reflexão teórica sobre os elementos da cosmopolítica em que se baseia a Autonomia Zapatista e aponta as dimensões em que essa meta-teoria, a partir da voz coletiva e do senti-pensamento situado dos povos, faz as suas leituras da política global.
Revisión sistemática de la práctica laboral pedagógica en educación superior: fundamentos teóricos y acciones clave
Authors: Tacuri Albarracín Verónica Gabriela , Vega Alonso Mery Elizabeth
Published: June 2024

Las prácticas laborales responden a un componente sustancial en el desarrollo de habilidades de los futuros profesionales, conllevando en sus procesos importantes hitos de desarrollo con el fin de lograr que los estudiantes adquieran destrezas que vinculen la teoría y la práctica para la futura inserción laboral. La presente investigación se centró en analizar y sistematizar los principales fundamentos teóricos, legales y acciones clave que sostienen la práctica laboral en contextos de educación de las universidades del Ecuador. Para ello, se empleó una investigación de tipo documental, la cual favoreció la revisión y reflexión de diferentes fuentes bibliográficas obtenidas de buscadores de alto impacto a través del análisis de contenido. Luego del análisis se concluyó que el desarrollo de las prácticas laborales en los procesos de formación y desarrollo profesional docente, permiten la gestión del conocimiento en las universidades desde el investigar para actuar en el propio campo de acción. Además, esta formación pedagógica se basa en aprender para servir, a medida que se adquieren e integran los conocimientos. Esto favorece brindar a la comunidad un servicio social de calidad, atendiendo las necesidades prioritarias en relación al ámbito educativo.
Procrastinación académica, adicción a redes sociales y funciones ejecutivas: Un estudio de autorreporte en adolescentes
Authors: Romero-Méndez Christian Alexis , Romero-Méndez Dan Lisandro
Published: June 2024

Las funciones ejecutivas (FE) son habilidades cognitivas importantes para regular la conducta y lograr objetivos de manera eficiente, especialmente en el contexto educativo, donde actúan como variables mediadoras en diversas problemáticas. Este estudio exploró la relación entre la procrastinación académica (PA), la adicción a las redes sociales (ARS), el rendimiento académico (RA) y las funciones ejecutivas (FE) en 132 adolescentes mexicanos, empleando un enfoque cuantitativo, de diseño no experimental y de corte transversal, con alcance descriptivo y correlacional. Se identificaron correlaciones significativas, revelando que la falta de control emocional e inhibición podría propiciar la ARS al impulsar un uso sin reflexión, buscando gratificación instantánea y dificultando la reflexión sobre consecuencias, aumentando la dependencia y la incapacidad de resistir impulsos. Además, se observó que una mayor ARS se asociaba con una mayor postergación académica, debido a que estas plataformas ofrecen distracciones que contribuyen a posponer responsabilidades académicas. También se identificó que la PA se vinculó con dificultades en las FE de planificación y organización, esenciales para estructurar eficientemente el tiempo y las actividades. Por último, un mejor desempeño en las FE evaluadas se correlacionó con un mejor RA, confirmando que estas habilidades cognitivas permiten a los estudiantes adaptarse a diversas demandas académicas. Como conclusión, los hallazgos subrayan la importancia de implementar estrategias para fortalecer las FE y prevenir consecuencias negativas asociadas con la PA, ARS y el bajo RA.
Microaprendizaje servicio a través de los sNOOC: propuesta formativa para personas en riesgo de exclusión en México.
Authors: Hueso Romero José Javier , García Blazquez Eduardo , Gil Quintana Javier
Published: June 2024

Los Nano Open Online Massive (NOOC) son pequeñas píldoras formativas similares a los MOOC, pero con una duración breve. Al acrónimo NOOC se añade la “s” de socialNOOC con la finalidad de definir este modelo formativo desde el empoderamiento del alumnado, la proyección del rol de e-teacher y la repercusión en la capa social. La propuesta formativa de microaprendizaje servicio a través de los sNOOC que presentamos en este artículo ha posibilitado la coordinación y dinamización de 110 estudiantes para la creación de los sNOOC y la formación de aproximadamente 500 personas de sectores en riesgo de exclusión de México. El análisis de las experiencias innovadoras diseñadas se ha efectuado partiendo de datos cuantitativos, que posibilitan las interacciones en la plataforma de educación a distancia; y cualitativos, a través de la etnografía virtual y las producciones de aprendizaje. Hemos podido comprobar como el trabajo realizado por los e-teacher, la interacción y la participación del alumnado en los sNOOC, no sólo ha posibilitado un mayor compromiso por el desarrollo de la asignatura, sino también el grado de satisfacción por el aprendizaje adquirido en la experiencia de didáctica de microaprendizaje servicio.