Abstract B26: Health-related quality of life in black breast cancer patients with Triple Negative Breast Cancer (TNBC)
Authors: Vadaparampil Susan T. , Christie Juliette , Donovan Kristine , Kim Jongphil , Augusto Bianca , Holt Cheryl , Ashing Kimlin , Halbert Chanita Hughes , Pal Tuya 
Published: March 2017

Purpose: Black women are more likely to develop early onset (age ≤50 years) breast cancer and have the lowest five year cause specific survival rate of any U.S. racial or ethnic group. The disparity in incidence and survival can be attributed partially to the higher rate of triple negative breast cancer (TNBC) in Blacks. Yet, little is known about health-related quality of life (HRQOL) among Black women with TNBC. Guided by the Contextual Model of HRQOL, the purpose of these analyses is to examine factors associated with HRQOL in patients with TNBC and non-TNBC.

Methods: Black women with invasive breast cancer at age ≤50 years and diagnosed between 2009-2012 were recruited through the Florida State Cancer Registry as part of a population-based case-only study to investigate etiology and outcomes of early-onset invasive breast cancer (n=456). A subset of participants (n=355) consented to complete additional study questions assessing those sociodemographic, clinical, and psychosocial variables selected based on the Contextual Model. The Functional Assessment of Cancer Treatment-Breast (FACT-G) was used to assess HRQOL. Descriptive analyses included those participants confirmed to have either TN or non-TN disease (n=330); univariable and multivariable analyses included participants who met the aforementioned criteria and completed baseline HRQOL data (n=299).

Results: Participants in the TNBC and non-TNBC group were similar (p&gt;0.05) with respect to age (TNBC: 41.4 ±5.9 years; non-TNBC: 42.2 ±6.5) and time since diagnosis (TNBC: 18.5 ±7.0 months; non-TNBC: 19.8±10.1). TNBC participants had lower mean FACT-G total scores (71 ± 22.3) compared to non-TNBC (77 ± 21.6) participants (p&lt;0.05). In the TNBC group, variables significantly associated in multivariable analysis with FACT-G scores included: current health, role limitation, anxiety, income, life stress, collectivism, and fatalism (p&lt;0.05). These three individual-level factors (current health, role limitation, and anxiety) and four systemic-level factors (income, life stress, collectivism, and fatalism) explained 80% of the response variation in HRQOL. In the non-TNBC group, factors significantly associated in multivariable analysis with FACT-G scores included: current health, role limitation, anxiety, depressed affect, cancer worry, income, life stress, social support, and birth country (p&lt;0.05). These five individual-level factors (current health, role limitation, anxiety, depressed affect, and cancer worry) and four system-level factors (income, birth country, life stress, and social support) accounted for 76% of the variation in HRQOL scores.

Conclusions: The Contextual Model of HRQOL provides a useful framework for evaluating HRQOL in Black breast cancer patients; differences based on triple negative disease status suggest possible intervention targets to improve HRQOL in these women. Effective interventions should focus on reducing anxiety at the individual level, with additional consideration for depressed affect, cancer worry, and social support in the non-TNBC group. For patients with TNBC, interventions may include addressing fatalistic cognitions and collectivist attitudes that may adversely affect HRQOL.

Citation Format: Susan T. Vadaparampil, Juliette Christie, Kristine Donovan, Jongphil Kim, Bianca Augusto, Cheryl Holt, Kimlin Ashing, Chanita Hughes Halbert, Tuya Pal. Health-related quality of life in black breast cancer patients with Triple Negative Breast Cancer (TNBC). [abstract]. In: Proceedings of the Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2016 Sep 25-28; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(2 Suppl):Abstract nr B26.