bluuebunny/crossref_metadata_2025 huggingface dataset:
How do I implement an outpatient program for the administration of convalescent plasma for COVID‐19?
Authors: Bloch Evan M. , Tobian Aaron A. R. , Shoham Shmuel , Hanley Daniel F. , Gniadek Thomas J. , Cachay Edward R. , Meisenberg Barry R. , Kafka Kimberly , Marshall Christi , Heath Sonya L. , Shenoy Aarthi , Paxton James H. , Levine Adam , Forthal Donald , Fukuta Yuriko , Huaman Moises A. , Ziman Alyssa , Adamski Jill , Gerber Jonathan , Cruser Daniel , Kassaye Seble G. , Mosnaim Giselle S. , Patel Bela , Metcalf Ryan A. , Anjan Shweta , Reisler Ronald B. , Yarava Anusha , Lane Karen , McBee Nichol , Gawad Amy , Raval Jay S. , Zand Martin , Abinante Matthew , Broderick Patrick B. , Casadevall Arturo , Sullivan David , Gebo Kelly A.
Published: March 2022

Convalescent plasma, collected from donors who have recovered from a pathogen of interest, has been used to treat infectious diseases, particularly in times of outbreak, when alternative therapies were unavailable. The COVID‐19 pandemic revived interest in the use of convalescent plasma. Large observational studies and clinical trials that were executed during the pandemic provided insight into how to use convalescent plasma, whereby high levels of antibodies against the pathogen of interest and administration early within the time course of the disease are critical for optimal therapeutic effect. Several studies have shown outpatient administration of COVID‐19 convalescent plasma (CCP) to be both safe and effective, preventing clinical progression in patients when administered within the first week of COVID‐19. The United States Food and Drug Administration expanded its emergency use authorization (EUA) to allow for the administration of CCP in an outpatient setting in December 2021, at least for immunocompromised patients or those on immunosuppressive therapy. Outpatient transfusion of CCP and infusion of monoclonal antibody therapies for a highly transmissible infectious disease introduces nuanced challenges related to infection prevention. Drawing on our experiences with the clinical and research use of CCP, we describe the logistical considerations and workflow spanning procurement of qualified products, infrastructure, staffing, transfusion, and associated management of adverse events. The purpose of this description is to facilitate the efforts of others intent on establishing outpatient transfusion programs for CCP and other antibody‐based therapies.
Computational Fluid Dynamics and Noncomputational Fluid Dynamics Applications Under Life-Long Association With Professor Kirti (Karman) Ghia
Authors: Mikhail Ameer G.
Published: March 2022

Six legacy case problems in fluid dynamics (FD), computational fluid dynamics (CFD), and applied aerodynamics applications that were studied during 1988–1996 are presented here. These are examples of my work reflecting the influence of Professor Ghia's teachings in numerical accuracy and truthful validations for CFD and FD in general. Three of the six examples are in the applied missile and projectile FD (aerodynamics) and three are for projectile CFD. Those workpieces were contemporary to the time when the debate on CFD numerical accuracy and uncertainty was in full thrust by the ASME Journal of Fluid Engineering and the AIAA (American Institute of Aeronautics and Astronautics), among other organizations. The debate was later culminated by the ASME's Journal of Fluid Engineering policy on numerical accuracy initiated in 1986 and revised in 1993 with the published 10 + 10 specific points/criteria, and their applications started to appear actually in journal publications in about 1996–1998.
The
In Vivo
and
In Vitro
Architecture of the Hepatitis C Virus RNA Genome Uncovers Functional RNA Secondary and Tertiary Structures
Authors: Wan Han , Adams Rebecca L. , Lindenbach Brett D. , Pyle Anna Marie
Published: March 2022

HCV has one of the most highly structured RNA genomes studied to date, and it is a valuable model system for studying the role of RNA structure in protein-coding genes. While previous studies have identified individual cases of regulatory RNA structures within the HCV genome, the full-length structure of the HCV genome has not been determined
in vivo
.
Efficacy of pembrolizumab in a rare type of bladder cancer arising 25 years after augmentation cystoplasty
Authors: Kitamura Kosuke , Isotani Shuji , Muto Satoru , Horie Shigeo
Published: March 2022

We report using the checkpoint inhibitor, pembrolizumab, as part of a multimodal treatment plan in a 36-year-old man with a rare bladder cancer arising 25 years after augmentation cystoplasty (sigmoid colonic cystectomy for neuropathic bladder was performed at 9 years old). On a regular clinic visit for clean intermittent catheterisation, the patient presented with gross haematuria and was diagnosed with urothelial carcinoma with sarcomatoid change. Gemcitabine and cisplatin-based neoadjuvant chemotherapy was unsuccessful, and pembrolizumab infusions (200 mg every 3 weeks) were initiated. A partial response was confirmed after six courses of pembrolizumab, with significant tumour shrinkage. A radical cystoprostatectomy and ileal conduit construction was performed, and pathology revealed no evidence of malignancy (ypT0, N0). The patient was successfully treated with the anti-programmed death-1 inhibitor, pembrolizumab, which was curative after total cystectomy. Further research is required to elucidate the potential role of checkpoint inhibitors in bladder cancers arising after augmentation cystoplasty.
Vaccination-associated immune thrombocytopenia possibly due to ChAdOx1 nCoV-19 (Covishield) coronavirus vaccine
Authors: Sivaramakrishnan Prakash , Mishra Mayank
Published: March 2022

Immune thrombocytopenia (ITP) is an acquired haemorrhagic diathesis of immune-mediated destruction, impaired production or increased splenic sequestration of platelets. It can be idiopathic (primary) or secondary (infections, medications, HIV infection, malignancies, connective tissue diseases or rarely secondary to vaccination). ITP postvaccination is termed vaccine-associated ITP (VITP) and is known to be caused by vaccines against various infectious agents such as measles-mumps-rubella,Haemophilus influenzae, pneumococcus, hepatitis B virus and human papilloma virus. Cases of VITP post SARS-CoV-2 vaccination have also been reported in the literature. Various hypotheses on the occurrence of the same are theorised, but no single theory has been proven to cause VITP conclusively. Management includes routine treatment of ITP with use of agents such as steroids, intravenous immunoglobulins, or on rare occasions a thrombopoietic agent or vinca alkaloids. We present a case of VITP possibly due to ChAdOx1 nCoV-19 (Covishield) vaccination in a middle-aged woman who responded to steroid therapy.
Adults’ with hearing loss perceived listening ability in daily communication: protocol for a systematic review and qualitative meta-synthesis
Authors: Hughes Sarah E , Boisvert Isabelle , McMahon Catherine , Steyns Anne , Neal Katie
Published: March 2022

Introduction

Understanding how adults with hearing loss perceive their abilities when listening in daily communication situations is vital to understanding the functional listening challenges associated with hearing loss. The aim of this study is to explore how adults with hearing loss describe their own experiences of the processes, behaviours and components of listening in real-world communication through secondary analysis of published qualitative data.

Methods and analysis

A systematic review and thematic meta-synthesis of qualitative research studies and qualitative components of mixed-methods studies will be conducted. Studies published in English will be identified through searching Medline, PsychInfo, Web of Science, Embase and Google Scholar databases from inception to November 2021. Handsearching of the included studies’ reference lists will be completed. Included articles will be assessed for methodological quality using the Critical Appraisal Skills checklist for qualitative studies. Thematic synthesis will proceed as follows: (1) line-by-line coding to label concepts present in the ‘results’ or ‘findings’ section(s) of the included studies; (2) grouping of similar codes into descriptive themes; (3) development of higher level analytic themes to develop a new interpretation of the included studies’ findings. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) Confidence in the Evidence from Reviews of QUALitative (CerQUAL) research approach will be used to establish the degree of confidence that may be placed in synthesis findings and results will be reported alongside the synthesis. Two reviewers will independently undertake screening for eligibility, data extraction and quality appraisal, analysis and GRADE-CERQual assessments. Discrepancies will be resolved through discussion.

Ethics and dissemination

As secondary data analysis of the published literature, ethical approval is not required. The results will be disseminated in peer-reviewed journals, conference presentations and other research and clinical meetings. This protocol is registered with PROSPERO prospective database of systematic review.

PROSPERO registration number

CRD42020213389.
Psychosocial impact of the COVID-19 pandemic and shielding in adults and children with early-onset neuromuscular and neurological disorders and their families: a mixed-methods study
Authors: Spurr Lydia , Tan Hui-Leng , Wakeman Ruth , Chatwin Michelle , Hughes Zachary , Simonds Anita
Published: March 2022

Aim

To describe and evaluate the psychosocial impact of the COVID-19 pandemic and measures to reduce the risk of transmission on patients with early-onset neuromuscular and neurological disorders (NMDs) and their families.

Design

A mixed-methods study in which data were collected between 17 September 2020 and 31 December 2020 using a semi-structured telephone questionnaire developed specifically to meet research aims, and were analysed using quantitative methods and qualitative inductive thematic analysis.

Participants

Forty questionnaires were completed by patients with NMDs (eg, muscular dystrophies, spinal muscular atrophy) or their parent. 70% (n=28) of patients were male, aged 2–48 years. 90% (n=36) were wheelchair users; 72.5% (n=29) required long-term non-invasive or tracheostomy ventilation.

Results

Strict adherence to risk mitigation strategies, for example, shielding, were reported at the start of the pandemic. Over half continued some or all measures after official limitations were relaxed. 67.5% (n=27) reported changes to personal care assistance arrangements including temporary cessation of outside carers. Three themes were identified: (1) Concern regarding the health impact of COVID-19; (2) Perceptions of strategies to prevent SARS-CoV-2 transmission; (3) Psychological impact of the COVID-19 pandemic. The level and pervasiveness of frequently reported negative psychological effects, for example, anxiety and fear fluctuated, and were related to the perceived risk of COVID-19, concern about attending hospital, and perceived lack of access to intensive care management if severe COVID-19 infection occurred. Support, particularly from family and healthcare services, were considered to have positive psychosocial effects.

Conclusions

Measures to reduce transmission of COVID-19 have greatly affected patients with NMDs and their families. For most, negative psychosocial impacts have and will continue to improve, but this may depend on the incidence of further pandemic waves. Consistent, up-to-date and accessible information on clinical outcomes and risk mitigation must be provided to support patients’ physical and mental well-being.
Performances of a portable Fourier transform hyperspectral imaging camera for rapid investigation of paintings
Authors: Candeo Alessia , Ardini Benedetto , Ghirardello Marta , Valentini Gianluca , Clivet Laurence , Maury Charlotte , Calligaro Thomas , Manzoni Cristian , Comelli Daniela
Published: March 2022

Scientific investigation in the cultural heritage field is generally aimed at the characterization of the constituent materials and the conservation status of artworks. Since the 1990s, reflectance spectral imaging proved able to map pigments, reveal hidden details and evaluate the presence of restorations in paintings. Over the past two decades, hyperspectral imaging has further improved our understanding of paints and of its changes in time. In this work, we present an innovative hyperspectral camera, based on the Fourier transform approach, utilising an ultra-stable interferometer and we describe its advantages and drawbacks with respect to the commonly used line- and spectral-scanning methods. To mitigate the weaknesses of the Fourier transform hyperspectral imaging, we propose a strategy based on the virtual extension of the dynamic range of the camera and on the design of an illumination system with a balanced emission throughout the spectral range of interest. The hyperspectral camera was employed for the analysis of a painting from the “Album of Nasir al-din Shah”. By applying analysis routines based on supervised spectral unmixing, we demonstrate the effectiveness of our camera for pigment mapping. This work shows how the proposed hyperspectral imaging camera based on the Fourier transform is a promising technique for robust and compact in situ investigation of artistic objects in conditions compatible with museum and archaeological sites.

Graphic abstract
Sandstone-body geometry and hydrostratigraphy of the northern High Plains Aquifer system, USA
Authors: Korus Jesse T. , Joeckel R.M.
Published: March 2022

Cenozoic sandstones of the North American interior host the voluminous High Plains Aquifer (HPA) system, which supplies water to
c.
30% of all irrigated farmland in the USA. Sandstone bodies in the HPA have eluded characterization because the correlation of discrete sedimentary units between boreholes is exceedingly difficult or even impossible. Our work, however, demonstrates that sandstone-body geometry can be characterized at regional, if not basinal scales, using multi-resolution methods, including remote sensing, outcrop mapping, borehole geophysics, and airborne electromagnetics. These and other scientific advances suggest that the HPA contains a complex assemblage of fluvial sandstone bodies with predictable dimensions. Hydrologic property contrasts between these sandstones and the enclosing, finer-grained strata define a complex arrangement of hydrostratigraphic units. We present this evolving understanding of HPA hydrostratigraphy in a new conceptual model that aids in the understanding of water-supply challenges. We maintain that sustaining well yields and aquifer productivity into the future depends on mapping the architecture of sandstone bodies in the subsurface using advanced techniques.

Thematic collection:
This article is part of the Hydrogeology of Sandstone collection available at:
https://www.lyellcollection.org/cc/hydrogeology-of-sandstone
Regulatory networks coordinating mitochondrial quality control in skeletal muscle
Authors: Slavin Mikhaela B. , Memme Jonathan M. , Oliveira Ashley N. , Moradi Neushaw , Hood David A.
Published: March 2022

The adaptive plasticity of mitochondria within a skeletal muscle is regulated by signals converging on a myriad of regulatory networks that operate during conditions of increased (i.e., exercise) and decreased (inactivity, disuse) energy requirements. Notably, some of the initial signals that induce adaptive responses are common to both conditions, differing in their magnitude and temporal pattern, to produce vastly opposing mitochondrial phenotypes. In response to exercise, signaling to peroxisome proliferator-activated receptor (PPAR)-γ coactivator-1α (PGC-1α) and other regulators ultimately produces an abundance of high-quality mitochondria, leading to reduced mitophagy and a higher mitochondrial content. This is accompanied by the presence of an enhanced protein quality control system that consists of the protein import machinery as well chaperones and proteases termed the mitochondrial unfolded protein response (UPRmt). The UPRmt monitors intraorganelle proteostasis, and strives to maintain a mito-nuclear balance between nuclear- and mtDNA-derived gene products via retrograde signaling from the organelle to the nucleus. In addition, antioxidant capacity is improved, affording greater protection against oxidative stress. In contrast, chronic disuse conditions produce similar signaling but result in decrements in mitochondrial quality and content. Thus, the interactive cross talk of the regulatory networks that control organelle turnover during wide variations in muscle use and disuse remain incompletely understood, despite our improving knowledge of the traditional regulators of organelle content and function. This brief review acknowledges existing regulatory networks and summarizes recent discoveries of novel biological pathways involved in determining organelle biogenesis, dynamics, mitophagy, protein quality control, and antioxidant capacity, identifying ample protein targets for therapeutic intervention that determine muscle and mitochondrial health.
Role of mechanosensitive channels/receptors in atherosclerosis
Authors: Mukherjee Pritha , Rahaman Suneha G. , Goswami Rishov , Dutta Bidisha , Mahanty Manisha , Rahaman Shaik O.
Published: March 2022

Mechanical forces are critical physical cues that can affect numerous cellular processes regulating the development, tissue maintenance, and functionality of cells. The contribution of mechanical forces is especially crucial in the vascular system where it is required for embryogenesis and for maintenance of physiological function in vascular cells including aortic endothelial cells, resident macrophages, and smooth muscle cells. Emerging evidence has also identified a role of these mechanical cues in pathological conditions of the vascular system such as atherosclerosis and associated diseases like hypertension. Of the different mechanotransducers, mechanosensitive ion channels/receptors are gaining prominence due to their involvement in numerous physiological and pathological conditions. However, only a handful of potential mechanosensory ion channels/receptors have been shown to be involved in atherosclerosis, and their precise role in disease development and progression remains poorly understood. Here, we provide a comprehensive account of recent studies investigating the role of mechanosensitive ion channels/receptors in atherosclerosis. We discuss the different groups of mechanosensitive proteins and their specific roles in inflammation, endothelial dysfunction, macrophage foam cell formation, and lesion development, which are crucial for the development and progression of atherosclerosis. Results of the studies discussed here will help in developing an understanding of the current state of mechanobiology in vascular diseases, specifically in atherosclerosis, which may be important for the development of innovative and targeted therapeutics for this disease.
Encoding of small-scale air motion dynamics in the cricket, Acheta domesticus
Authors: Mulder-Rosi Jonas , Miller John P.
Published: March 2022

A set of sensory interneurons that have been studied for over 30 years by several different research groups were discovered to have previously unknown encoding characteristics. As well as encoding the direction of bulk airflow with a coarse-coding scheme as shown in previous studies, these interneurons are also responsive to very small-scale, directionally complex air current waveforms. This feature sensitivity can be understood in terms of the cells’ complex dendritic branching patterns.
Postural control strategies are revealed by the complexity of fractional components of COP
Authors: Moreno F. J. , Caballero C. , Barbado D.
Published: March 2022

The relationship between the complexity of the center of pressure (COP) and balance performance is not fully established. The task constraints and the filtering decomposition of the COP could influence this relationship. COP complexity is related to a better balance performance only in low frequencies and midfrequencies of the COP. The different frequencies measure different postural control components. Filtering decomposition should be explored in future studies to address the underlying mechanisms of postural control.
Changes in visual speed perception induced by anticipatory smooth eye movements
Authors: Miyamoto Takeshi , Numasawa Kosuke , Ono Seiji
Published: March 2022

We provide psychophysical evidence that the execution of anticipatory smooth eye movement (ASEM) leads to underestimation of visual speed perception, that is, observers perceive the object motion velocity as slower than when ASEM is not induced, even though the performance of subsequent ocular tracking is comparable. Moreover, our results showed that such perceptual decisions regarding object motion velocity were derived from the ASEM-induced decrease in retinal slip velocity during the initial phase of ocular tracking.
Research on Optimization Algorithm for Resource Allocation of Heterogeneous Car Networking Engineering Cloud System Based on Big Data
Authors: Yao Junping
Published: March 2022

A big data-based heterogeneous Internet of Vehicles engineering cloud system resource allocation optimization algorithm is proposed for the sake of meeting the needs of Internet of Vehicles applications and improving the rationality and efficiency of cloud system resource allocation. Based on taking the minimum cloud system delay as the resource allocation target, a multislot cloud system delay optimization model and its indicative function are constructed, the probability distribution function is derived according to the obtained multidimensional probability distribution function set, and the available channels of the vehicle in different time periods are determined. In this way, the matching degree between the vehicle and the channel is solved, the delay optimization model is turned into a convex optimization problem with independent variables, and the resource allocation algorithm for different task offload destinations is optimized. Meanwhile, by building a heterogeneous vehicle network simulation system, the performance of the algorithm is evaluated from the perspectives of resource rental cost, weighted resource utilization, and bit loss rate. As can be learned from the simulation results, the proposed algorithm can effectively reduce the cost of resource rental, and at the same time, the advantages of resource utilization and bit loss rate are relatively significant, so it has certain effectiveness and practicability.
CTRF: Ethereum-Based Ponzi Contract Identification
Authors: He Xuezhi , Yang Tan , Chen Liping
Published: March 2022

In recent years, blockchain technology has been developing rapidly. More and more traditional industries are using blockchain as a platform for information storage and financial transactions, mainly because of its new characteristics of non-tamperability and decentralization compared with the traditional systems. As a representative of blockchain 2.0, Ethereum has gained popularity upon its introduction. However, because of the anonymity of blockchain, Ethereum has also attracted the attention of some unscrupulous people. Currently, millions of contracts are deployed on Ethereum, many of which are fraudulent contracts deployed by unscrupulous people for profit, and these contracts are causing huge losses to investors worldwide. Ponzi contracts are typical of these contracts, which mainly reward the funds invested by later investors to early investors, and later investors will have no gain. However, although there are some studies for identifying Ponzi contracts on Ethereum, there is some room for progress in the research. Therefore, we propose a method to detect Ponzi scheme contracts on Ethereum-CTRF. This method forms a dataset by extracting the word features and sequence features of the smart contract’s code and the features of transactions. The dataset is divided into a training set and a test set. Oversampling is performed on the training set to deal with the problem of positive and negative sample imbalance. Finally, the model is trained on the training set and tested on the test set. The experimental results show that the model has significantly improved recall compared with existing Ponzi contract detection methods.
Planning the Emergency Collision Avoidance Strategy Based on Personal Zones for Safe Human‐Machine Interaction in Smart Cyber‐Physical System
Authors: Nguyen Thanh Phuong , Nguyen Hung , Thinh Ngo Ha Quang
Published: March 2022

Human contact is a key issue in social interactions for autonomous systems since robots are increasingly appearing everywhere, which has led to a higher risk of conflict. Particularly in the real world, collisions between humans and machines may result in catastrophic accidents or damaged goods. In this paper, a novel stop strategy related to autonomous systems is proposed. This control method can eliminate the vibrations produced by a system’s movement by analysing the poles and zeros in the model of autonomous vehicles and goods. Using the pole placement technique, the motion of a system is guaranteed to be more stable, more flexible and smoother. Moreover, several control profiles are employed in the switching mechanism to choose the proper vibration‐free effect. The main contributions of this paper are (i) the recommendation of an active stopping planner using different smooth generators from a modelling study, (ii) the validation of their physical characteristics and (iii) the launching of a switching algorithm based on the socially aware navigation framework of a robot. This theoretical work is based on the virtual environment of MATLAB, and the experiment is implemented in the practical platform of an automated guided vehicle. From these results, it can be seen that the proposed approach is robust, effective and feasible for applications in storehouse management, public transportation or factory manufacturing.
PPSEB: A Postquantum Public-Key Searchable Encryption Scheme on Blockchain for E-Healthcare Scenarios
Authors: Xu Gang , Xu Shiyuan , Cao Yibo , Yun Fan , Cui Yu , Yu Yiying , Xiao Ke
Published: March 2022

In the current E-healthcare scenarios, medical institutions are used to encrypt the information and store it in an Electronic Health Record (EHR) system in order to ensure the privacy of medical information. To realize data sharing, a Public-key Encryption with Keyword Search (PEKS) scheme is indispensable, ensuring doctors search for medical information in the state of ciphertext. However, the traditional PEKS scheme cannot resist the keyword guessing quantum computing attacks, and its security depends on the confidentiality of the secret key. In addition, classical PEKS hand over the search process to a third party, affecting the search results’ accuracy. Therefore, we proposed a postquantum Public-key Searchable Encryption scheme on Blockchain (PPSEB) for E-healthcare scenarios. Firstly, we utilized a lattice-based cryptographic primitive to ensure the security of the search process and achieve forward security to avoid key leakage of medical information. Secondly, we introduced blockchain technology to solve the problem of third-party untrustworthiness in the search process. Finally, through security analysis, we prove the correctness and forward security of the solution in the E-healthcare scenarios, and the comprehensive performance evaluation demonstrates the efficiency of our scheme compared with other existing schemes.
Research and Application of Intelligent Layout Design Algorithm for 3D Pipeline of Nuclear Power Plant
Authors: Zhang Jie , Wu Liangjun , Hu Jiakun , Zhao Dong , Wan Jiaoyi , Xu Xinwei
Published: March 2022

The pipeline layout design of nuclear power plant is to find the optimal route to meet the objectives and constraints in the 3D routing space. However, due to the intensive equipment and complex structure of the nuclear power plant, various types of pipeline systems, complex layout constraints, and a large number of pipelines, even for experienced designers, pipeline layout is a difficult and time-consuming task. In order to solve the problem of the automatic layout of pipeline in 3D routing space of nuclear power plant, a pipeline automatic routing method combining Dijkstra algorithm in large space and improved A∗algorithm in local space is proposed in this paper. Firstly, the method identifies the key vertices of each room in the nuclear power plant, constructs the topological routing map, and determines the preliminary passage area of the pipeline through the traditional Dijkstra algorithm. Secondly, the space of the layout area is divided into 3D grids, and then the items in the area are identified and preprocessed. Finally, the 3D pipeline routing environment is established through AABB-OBB hybrid collision detection technology. On this basis, the improved method of A∗evaluation function is given to satisfy the pipeline layout constraints and improve the search efficiency. Through experiments, the effectiveness of this method is proved. This method can quickly and automatically route the nuclear power pipelines that meet the requirements of the engineering, which greatly improves the efficiency of 3D pipeline layout design for the nuclear power plant.
Wenyang Huazhuo Tuihuang Formula Inhibits the Th17/Treg Cell Imbalance and Protects against Acute-on-Chronic Liver Failure
Authors: Wang Xiufeng , Zhong Yunqing , Zhang Rongzhen , Chen Yueqiao , Wang Minggang , Lv Chao , Mao Dewen
Published: March 2022

Objective. Acute-on-chronic liver failure (ACLF) is a group of chronic liver diseases and caused by acute internal and external liver injury. Wenyang Huazhuo Tuihuang (WYHZTH) formula had a good clinical effect on promoting the resolution of jaundice. The aim of this study is to further investigate the mechanism of the WYHZTH formula in the ACLF rat model. Methods. The ACLF rat model was constructed by combining human serum albumin with LPS and D-gal. WYHZTH was used to intervene and treat. The cytokines IL-17, IL-23, IL-10, and TGF-β were detected by ELISA and fluorescence-quantitative PCR. Flow cytometry was used to detect the percentage of Th17 and Treg cells in the peripheral blood and liver tissues of each group of rats. The pathological changes in the liver tissue were detected by hematoxylin-eosin staining, immunohistochemistry, and electron microscopy. Results. Compared with the ACLF group, the WYHZTH formula and Thy significantly decreased the levels of ALT, AST, and CHE in the ACLF group. After drug intervention, apoptosis was significantly reduced. The PCNA expression decreased in the ACLF model group but increased in the WYHZTH or Thy group. Under transmission electron microscope, hepatocytes in the ACLF group showed obvious necrosis. After drug intervention, hepatocyte necrosis was reduced with most of the structure returning to normal. Conclusion. This present study demonstrated that WYHZTH formula may protect against acute-on-chronic liver failure, which may be related to the inhibition of Th17/Treg cell imbalance.
A Novel Highly Nonlinear Quadratic System: Impulsive Stabilization, Complexity Analysis, and Circuit Designing
Authors: Ramesh Arthanari , Bahramian Alireza , Natiq Hayder , Rajagopal Karthikeyan , Jafari Sajad , Hussain Iqtadar
Published: March 2022

This work introduces a three‐dimensional, highly nonlinear quadratic oscillator with no linear terms in its equations. Most of the quadratic ordinary differential equations (ODEs) such as Chen, Rossler, and Lorenz have at least one linear term in their equations. Very few quadratic systems have been introduced and all of their terms are nonlinear. Considering this point, a new quadratic system with no linear term is introduced. This oscillator is analyzed by mathematical tools such as bifurcation and Lyapunov exponent diagrams. It is revealed that this system can generate different behaviors such as limit cycle, torus, and chaos for its different parameters’ sets. Besides, the basins of attractions for this system are investigated. As a result, it is revealed that this system’s attractor is self‐excited. In addition, the analog circuit of this oscillator is designed and analyzed to assess the feasibility of the system’s chaotic solution. The PSpice simulations confirm the theoretical analysis. The oscillator’s time series complexity is also investigated using sample entropy. It is revealed that this system can generate dynamics with different sample entropies by changing parameters. Finally, impulsive control is applied to the system to represent a possible solution for stabilizing the system.
Chemical Composition, Total Phenolic Content, and Antioxidant Activity of the Essential Oils Extracted from the Needle of Ten Pinus Taxa
Authors: Liu Zhihong , Fan Weixin , Xie Qing
Published: March 2022

This study investigated the chemical compositions of essential oils (EOs) from ten taxa belonging to the Pinus genus. The studied taxa that grow wildly in China, and the EOs were extracted by steam distillation; the chemical compositions were isolated and characterized by GC-MS. Eighty-one components, representing over 92.10% of the EOs, were identified. The main constituents of EOs were α-pinene (6.44%–53.00%), β-caryophyllene (2.43%–24.64%), β-pinene (0.00%–22.32%), δ-cadinene (2.56%–17.56%), germacrene D (0.74%–11.38%), and camphene (0.78%–10.48%). Furthermore, we determined the total phenolic content (TPC) of the EOs, with the values from 26.50 to 60.01 mg eq GAE/mL EO. DPPH free radical scavenging activity (DPPH), ferric reducing antioxidant power (FRAP), and ABTS radical cation scavenging activity (ABTS) were used to evaluate the antioxidant capacity of the EOs, and the obtained values were ranged from 499.15 to 1,272.75 mmol eq Trolox/mL EO, 1,255.67 to 3,857.93 mmol eq Trolox/mL EO, and 370.81 to 1,677.19 mmol eq Trolox/mL EO, respectively. The results showed that all of the EOs studied had strong antioxidant activity, and these pine plants could be used as natural antioxidants in functional food and pharmaceutical industries.
Blockchain-Based Model for Intelligent Supply Chain Production and Distribution
Authors: Gu Shurui , Pan Weihwa , Chung Tsungting , Huang Xuening
Published: March 2022

Blockchain is a term in the field of information technology. In essence, it is a shared database, and the data or information stored in it has the characteristics of “unforgeable,” “full traces,” “traceable,” “open and transparent,” and “collective maintenance.” Based on these characteristics, blockchain technology has laid a solid “trust” foundation, created a reliable “cooperation” mechanism, and has broad application prospects. This paper is aimed at studying a method in view of the integrate of system analysis and system simulation to solve the problems in the production and distribution (P&D) system in the supply chain, proposing a more realistic optimization plan, and then promoting it to various enterprises. This article proposes the idea of using supply chain management, through system analysis, system simulation, case analysis, and comparative research methods, starting from the strategic level, tactical level, and operation level of supply chain management to optimize the P&D system. Pay attention to the P&D system issues in the supply chain environment, and apply the method of system analysis and system simulation to get a better P&D plan. The experimental results of this paper show that the total cost of the supplier selection strategy is 5.204 million yuan, and the delayed delivery rate is 30%. The new reconstruction strategy makes the total cost as low as 3,809,700 yuan, and the total delayed delivery rate is as low as 7%.
Application of Anabaena azotica- and Chlorella pyrenoidosa-Based Algal Biotechnology in Green Production of Algae-Rich Crataegi fructus
Authors: Wang Kangjie , Hu Beijuan , Zheng Chuangang , Deng Zhiyi , Duan Jian , Qin Kangxi , Cui Xinwei , Li Shifeng
Published: March 2022

Nitrogen-fixing Anabaena and Chlorella pyrenoidosa algal biotechnology are known as new agricultural inputs due to their characteristics and are widely used in the field of agricultural planting. This paper discusses the application of algal biotechnology based on nitrogen-fixing Anabaena sp. The advantages of algal biotechnology based on nitrogen-fixing Anabaena and Chlorella pyrenoidosa in terms of yield, sugar content, polyunsaturated fatty acid content, and high-quality yield of hawthorn were compared.
Study on the Effect of Crushed Rice-Lotus Seed Starch Reconstituted Rice on Lipid Metabolism Histology in Rats
Authors: Zhang Yun-Liang , Dou Bo-Xin , Wang Yan , Liu Ji-Jun , Zhang Zhi , Liu Ying , Zhang Na
Published: March 2022

The study investigated the changes of lipid metabolism histology in rats under the three groups of dietary modifications after dietary intervention in (Sprague-Dawley, SD) SD rats using lotus seed reconstituted rice, ordinary rice, and high-fat feed made from lotus seed starch-rice flour after extrusion and puffing. It was found that the high-fat feed could lead to the disorder of lipid metabolism in rats, and the accumulation of lipid metabolism substances caused by the high-fat feed was significantly increased; the intervention of ordinary rice and high-dose reconstituted rice revealed that the high-dose reconstituted rice could improve the disorder of lipid metabolism and the accumulation of lipid substances caused by the high-fat feed to a greater extent. The main lipid substances were PC, TAG, Cer, CE, SM, PE, LPC, Acar, DAG, FAHFA, OxPI, PI, SQDG, Cer/NS, GlcADG, HBMP, Cer/NDS, HexCer/NS, etc., and the study confirmed that the reconstituted rice made from lotus seeds in this experiment was better than ordinary rice, and the high-dose reconstituted rice obtained from the study has a better modulating effect on lipid metabolism disorders and organism damage caused by high-fat feed.
Design and Application of Intelligent Processing Technology for Animation Images Based on Deep Learning
Authors: Zheng Jie
Published: March 2022

The origins of anime can be traced all the way back to the Homo sapiens period of human civilization. Nowadays, anime is a record of life as well as a popular kind of entertainment and a source of ideal trust for many individuals. Children and individuals of all classes and ages enjoy anime. In the opinion of most people, anime is not simply a form of amusement and pleasure, but it can also express deeper meanings, transmit other cultures, and inspire individuals to pursue their aspirations. Image stylistic migration based on convolutional neural networks has developed as a central research path in recent years, and attempts on style migration have evolved as well. However, there are few studies on style migration. In this paper, we propose a deep learning-based solution to the problem of anime-style migration. Experiments on a relevant database show that our proposed method is effective and accurate and has commercial and academic significance.
The Creep Test Study and Macro‐Detail Analysis of Argillaceous Red Sandstone in Different Water‐Containing States
Authors: Guo Shuntao , Wen Shujie , Guo Hongyu , Fu Helin
Published: March 2022

In order to study the creep characteristics and failure mechanism of argillous red sandstone in a water‐bearing state, uniaxial creep tests of argillous red sandstone under dry and saturated states are carried out under fractional loading. Burgers model is used to fit the test results and identify the parameters, and scanning electron microscopy is carried out on the cross section of the damaged sample. The mechanism of creep difference of argillaceous red sandstone with different water content is studied from the microscopic point of view. The results show that the uniaxial compressive strength of the saturated clay red sandstone is 46% of that of the dry clay red sandstone. The deformation level of the saturated clay red sandstone is lower than that of the dry clay red sandstone. The limit deformation of the creep failure of the water‐bearing clay red sandstone is much smaller than that of the dry clay red sandstone. The long‐term strength of the muddy red sandstone is 46.4 MPa in the dry state and only 14.1 MPa in the saturated state, as calculated at the steady‐state creep rate. It is found that the Burgers model can describe the attenuation and stable creep of muddy red sandstone well. Through macro‐ and microanalysis, it is found that the compression failure form of argillaceous red sandstone belongs to x‐shaped conjugate inclined plane shear failure. After saturation, the internal pores of argillaceous red sandstone become larger, and the cementation ability decreases, resulting in the decrease of rock sample strength.
Reference Genes for qPCR-Based miRNA Expression Profiling in 14 Human Tissues
Authors: Veryaskina Yulia Andreevna , Titov Sergei Evgenievich , Zhimulev Igor Fyodorovich
Published: March 2022

MicroRNAs (miRNAs) are promising biomarkers for the diagnosis and prognosis of various diseases. Quantitative PCR is the most frequently used method of measuring expression levels of miRNA. However, the lack of validated reference genes represents the main source of potential bias in results. It is normal practice to use small nuclear RNAs as reference genes; however, they often have variable expression. Researchers tend to prefer the most stable reference genes in each experiment. The review includes reference genes for the following tissue types: gliomas, lung cancer, melanoma, gastric cancer, liver cancer, prostate cancer, breast cancer, thyroid cancer, ovarian cancer, cervical cancer, endometrial cancer, rectal cancer, blood tumors, and placental tissues.
Attitudes toward research and its impact to research skills development among Grade 12 students of Meycauayan National High School
Authors: Serrano Erickson
Published: March 2022

The primary concern of this research paper was to relate how Grade 12 students of Meycauayan National High School perceived research subjects such as Practical Research 2 and how these attitudes toward research affected their research skills development.

With the purpose of bridging the link between the affective domains of learning to how students develop their research skills, the researcher used the Attitude Towards Research (ATR) Scale developed by Papanastasiou (2002) and a Research Skills Assessment Test based on Gilmore and Feldon (2010). These instruments were administered to 60 Grade 12 Senior High School students of MNHS across different strands, while accompanied with Active Learning Classroom Strategies in teaching Practical Research 2. Through pre-test and post-test design, the researcher evaluated the impact of the students’ attitudes toward research in five (5) factors. These five factors were generalized as Post-ATR and was correlated to the Final Grades of the respondents in Practical Research 2.

Upon data analysis using t-test and correlational statistics, it was highlighted that participants were more focused on how Research subjects are with utmost relevance and usefulness to their everyday lives, though, many of them still gave concern on anxiety and difficulty of the subject. It was also evident that in general, how students feel about research has a great impact on how they develop their research skills along the course.

Through this study that found that improved attitudes toward research significantly increased the students’ research skill and with the help of the data analyzed in this paper, the researcher encourage teachers to not only focus on students’ cognitive and psychomotor skills but to give equal importance as well with the attitudes toward research as these would contribute to students’ overall research skill development.
Sarcoma de Kaposi pós-transplante hepático: relato de caso
Authors: Fernandes Amanda Melo , Leal Maria Teresa de Souza Portela , Bezerra Jéssika Melo Leão , Cardozo Moara Maria Silva , Siqueira Betty Janny Maia
Published: March 2022

Introdução: O sarcoma de Kaposi constitui uma neoplasia maligna multicêntrica caracterizada pelo desenvolvimento de tumores vinhosos, os quais podem ser observados tanto na pele e no tecido subcutâneo como em vísceras. O objetivo deste estudo foi relatar um caso de sarcoma de Kaposi após transplante hepático, pela raridade da ocorrência desse evento. Método: O instrumento de investigação usado para a condução deste relato foi o estudo de caso, com a coleta das informações em prontuário físico do paciente. Relato do Caso: Homem de 28 anos, com história de uso de Tacrolimus há três anos devido a transplante hepático, apresentando dor abdominal associada a diarreia, diagnosticado por meio de histopatológico de pólipo intestinal com sarcoma de Kaposi, encaminhado para tratamento quimioterápico. Considerações Finais: Pacientes receptores de transplantes de órgãos sólidos que recebem medicações imunodepressoras devem ter novos sintomas cuidadosamente investigados, para possibilitar diagnóstico neoplásico precoce.
Biogeography and taxonomy of Ophiuroidea (Echinodermata) from the Îles Saint-Paul and Amsterdam in the southern Indian Ocean
Authors: O’HARA TIMOTHY D. , THUY BEN
Published: March 2022

The ophiuroid fauna of the Île Amsterdam and Île Saint-Paul territories (SPA) is reviewed. Four new species are described: Ophiolebes felli, Ophiolebes paulensis, Ophiocomina arnaudi and Amphiura remota. Recent phylogenetic results required a partial reorganisation of Ophiacanthidae and Amphiuridae genera, including the transfer of some Ophiacantha and Ophiomitrella species to a new genus Ophiosabine (O. rosea, O. anomala, O. aristata, O. cuspidata, O. densispina, O. nodosa, O. notata, O. parcita, O. pentactis, O. vivipara, O. wolfarntzi) and existing genera Ophiosemnotes (O. conferta, O. ingrata, O. corynephora, O. clavigera, O. hamata) and Ophiolebes (O. yaldwyni), Ophiacantha spectabilis to Ophiotreta in the Ophiotomidae, and some Amphioplus species to Amphiura (A, acutus, A. ctenacantha, A. cipus). The combination Ophiophycis nixastrum is restored. The SPA endemic species Ophiocten lymani and Amphiura brevispina, and the southern Australian/New Zealand species Ophiactis cuspidata and Ophiocten australis, are recognised as valid species. The North Atlantic species Ophiura ljungmani, Ophiacantha veterna, Ophiosabine cuspidata, Ophiolimna bairdi and Ophiactis nidarosiensis are recorded from the southern Indian Ocean. Shallow water specimens of Ophiura ljungmani from the Western Atlantic are re-identified as O. fallax and O. acervata. The monotypic Ophiothauma heptactis from northern Australia is synonymised with Ophiocomella sexradia and thus the genus Ophiothauma with Ophiocomella. The biogeography of the ophiuroid fauna reflects the position of the islands near the eastward-flowing currents of the South Indian Ocean gyre. The closest affinities are with faunas in the SW Indian Ocean and SE Atlantic Ocean. Despite its proximity, no species are shared with the Kerguelen Plateau to the south. The large temperature gradient across the subtropical front between Île Saint-Paul and Kerguelen appears to be a distribution limit for littoral and upper bathyal invertebrates.