bluuebunny/crossref_metadata_2025 huggingface dataset:
Female protection against diabetic kidney disease is regulated by kidney-specific AMPK activity
Authors: Joo Lee Hak , Min Liang , Gao Jingli , Matta Shane , Drel Viktor , Saliba Afaf , Tamayo Ian , Montellano Richard , Hejazi Leila , Maity Soumya , Xu Guogang , I. Grajeda Brian , Roy Sourav , R. Hallows Kenneth , Ghosh Choudhury Goutam , S. Kasinath Balakuntalam , Sharma Kumar
Published: April 2024

Reduced kidney AMPK activity is associated with nutrient stress-induced chronic kidney disease (CKD) in male mice. In contrast, female mice resist nutrient stress-induced CKD. The role of kidney AMPK in sex-related organ protection against nutrient stress and metabolite changes were evaluated in diabetic kidney tubule-specific AMPKg2KO (KTAMPKg2ΚΟ) male and female mice. In WT males, diabetes increased albuminuria, urinary kidney injury molecule-1, hypertension, kidney p70S6K phosphorylation, and kidney matrix accumulation; these features were not exacerbated with KTAMPKg2ΚΟ. Whereas WT females had protection against diabetes induced kidney injury, KTAMPKg2ΚΟ led to loss of female protection against kidney disease. 17b-estradiol ameliorated high glucose-induced AMPK inactivation, p70S6K phosphorylation and matrix protein accumulation in kidney tubule cells. The mechanism for female protection against diabetes-induced kidney injury is likely via an estrogen-AMPK pathway, as inhibition of AMPK led to loss of estrogen protection to glucose-induced mTORC1 activation and matrix production. RNA-seq and metabolomic analysis identified a decrease in the degradation pathway of phenylalanine and tyrosine resulting in increased urinary phenylalanine and tyrosine levels in females. The metabolite levels correlated with loss of female protection. The findings provide new insights to explain evolutionary advantages to females during states of nutrient challenges.
Prognostic Value of the Neutrophil-to-lymphocyte Ratio, Platelet-to- lymphocyte Ratio and Monocyte-to-lymphocyte Ratio in Melanoma Patients: A Cohort Study
Authors: Ertekin Sümeyre Seda , Mangas Cristina , Riquelme-Mc Loughlin Constanza , Carrera Cristina , Malvehy Josep , Puig Susana , Podlipnik Sebastian
Published: April 2024

The prognostic value of the neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and monocyte-lymphocyte ratio in patients with melanoma has yielded controversial results in the literature. A retrospective single-centre cohort study was conducted from 1998 to 2020, including patients diagnosed with invasive melanoma. A total of 2,721 patients were included in the study. The median follow-up was 8.23 years (IQR 4.41–13.25). The median baseline neutrophil- lymphocyte ratio, platelet-lymphocyte ratio and monocyte-lymphocyte ratio values increased significantly (p < 0.001) with the increasing American Joint Committee on Cancer stage. The optimal cut-off values for neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and monocyte-lymphocyte ratio were determined as 2.1, 184 and 0.2, respectively. In the multivariate analysis, high levels of neutrophil-lymphocyte ratio (≥ 2.1), platelet-lymphocyte ratio (≥ 184) and monocyte-lymphocyte ratio (≥ 0.2) were independently associated with significantly shorter melanoma-specific survival (neutrophil-lymphocyte ratio: HR 1.30, 95% CI 1.06–1.60, p = 0.013; platelet-lymphocyte ratio: HR 1.37, 95% CI 1.06–1.76, p = 0.014; monocyte- lymphocyte ratio: HR 1.29, 95% CI 1.05–1.58, p = 0.015) and overall survival (neutrophil-lymphocyte ratio: HR 1.39, 95% CI 1.19–1.64, p < 0.001; platelet- lymphocyte ratio: HR 1.44, 95% CI 1.19–1.74, p < 0.001; monocyte-lymphocyte ratio: HR 1.42, 95% CI 1.21–1.66, p < 0.001). High levels of neutrophil- lymphocyte ratio and monocyte-lymphocyte ratio were also associated with poor relapse-free survival, while platelet-lymphocyte ratio was not. In conclusion, baseline neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and monocyte-lymphocyte ratio were identified as independent predictors for the prognosis of melanoma.
Two New Strains of Drug-resistant Neisseria gonorrhoeae in a Bisexual Man having Sex with Men in Wroclaw, Poland
Authors: Biała Martyna , Pencakowski Bartosz , Mączyńska Beata , Starzyński Konrad , Szetela Bartosz
Published: April 2024

Abstract is missing (Short communication)
ADAM-technológiájú 3D-s fémnyomtatás
Authors: Hegedűs Ernő
Published: April 2024

A tanulmány bemutatja az ADAM-technológiájú 3D-s fémnyomtatást. Kitér a magas olvadáspontú fémek nyomtathatóságára, az ADAM 3D-s nyomtatás lehetőségeire, illetve e fémek megjelenésének a haditechnika fejlődésére gyakorolt hatására. Kitér a zárt belső szerkezetek, cellák előállításának lehetőségére és előnyeire. Ismerteti az UAV-k  sárkány és hajtómű-rendszereinek, illetve egyes könnyűjárművek fémszerkezeti elemeinek gyárthatósági előnyeit ADAM-technológiájú 3D-s nyomtatással.
Pedagogical conditions for the use of a computer game educational complex for instrumental support of a speech therapist activity
Authors: Рудинский И.Д. , Лутовинова А.М.
Published: April 2024

В статье описаны педагогические условия, формулирование и выполнение которых способствует созданию и результативному применению комплексов компьютерных игр логопедического назначения в профессиональной деятельности педагога-логопеда.

The article describes the pedagogical conditions, the formulation and implementation of which contributes to the creation and effective use of computer game complexes for speech therapy purposes in the professional activity of a speech therapist.
Management and Organization of Human Resources in Science and Technology of the Republic of Serbia
Authors: Milutinović Olivera , Anđelić Slavica , Garabinović Dušan , Bajac Momčilo
Published: April 2024

The subject of this paper is human resources in the field of science and technology in the Republic of Serbia. The aim is to establish the state and tendencies regarding the number and structure of human resources in the mentioned field. Accordingly, several research questions were defined. Open data (2018-2021) of the Statistical Office of the Republic of Serbia were used. The results showed that the average number of employees who have either higher education or are employed in the field of science and technology was 991.9 thousand and on average their number was growing. The majority were women, whose number and share increased on average. The average number of employees who have higher education and are employed in the field of science and technology was 501.4 thousand and their number was growing on average, including people of both genders. The majority were women, whose share was constant with a tendency to minimal decrease. The average number of employees aged 15-74 who are employed in the field of science and technology was 731.2 thousand and on average their number was growing, including persons of both genders. The majority were women, whose share was constant with a tendency to minimal increase. The most important sector in the field of science and technology was education. It is concluded that there are positive tendencies regarding the number of human resources in the field of science and technology in Serbia, especially when it comes to women.
Identidade, manifestação e repressão entre os aqueus (Tersites na Ilíada, Canto 2)
Authors: Frade Gustavo
Published: April 2024

Ao contrário de todos os outros guerreiros da Ilíada, identificados pela filiação ou pela região de origem, Tersites não é introduzido como representante de nenhuma terra, nem é apresentado como filho de ninguém. Na falta de uma identidade e de uma posição social explicitamente definidas, Tersites é caracterizado, a princípio, pelas particularidades de seu discurso e, logo em seguida, por sua aparência única. A posição social de Tersites, entretanto, não é evidente no poema. A proposta deste texto, assim, é entender o episódio de Tersites e sua caracterização partindo do contexto narrativo em que a personagem aparece (a Diapeira, o teste do exército), para depois recuperar sua identidade, comparando a Ilíada com outras fontes antigas das histórias tradicionais sobre a Guerra de Troia, e então ler seu discurso, tendo em vista a resposta violenta que ele recebe. A caracterização de Tersites, que o integra de forma peculiar a essa poesia que canta os feitos memoráveis dignos de elogio, é parte de sua função narrativa tradicional de repreender e ser repreendido. A Ilíada, no entanto, silencia as origens aristocráticas de Tersites para descolar da aristocracia guerreira seus traços físicos e morais negativos.
O Epinício 3 de Baquílides
Authors: Brose Robert de
Published: April 2024

In this article I propose an exegetical and philological commentary on Bacchylides’ Epinician 3 accompanied by a poetic translation that incorporates the results into the target text in Brazilian Portuguese. My intention with this commentary is not only to draw the reader’s attention to the sophistication and complexity that underlies the apparent simplicity of Bacchylides’ poetry, but also to present new critical results regarding the poem’s exegesis. In the commentary, therefore, I explain my reasons for changing the textus receptus of Kenyon (1897) and Maehler (2003) at certain points, to reflect the advances made by textual criticism in recent years, as well as my own interpretation of certain passages. In this commentary, I also explain my translation choices whenever they diverge from more traditional ones.
Cartographical digital products: Maps, 3D models, diagrams
Authors: Georgiou Efthymios Spyridon
Published: April 2024

The current paper aims at spatial presentation in Cinque Terre. The purpose is to reconstruct digital products (maps, statistics, diagrams, 3D models) and the spatial analysis of the five villages. The goals are the presentation of the geomorphology, geography, population, density, and area. Also, the Strength-Weakness-Opportunities-Threats (SWOT) analysis creates the region disadvantages advantages of the five villages. The methodology is based on the software (G.I.S Pro, QGIS, Zephyr 3D, Microsoft Excel, Generic Mapping Tool) and the bibliography study. For instance, the construction 3D terrain model shows the buildings, roads, green areas, and land cover of the five villages. The digital products help better “reading” the region and emphasize the measurements and location of the region’s elements. The final results contain a message about new technologies and spatial planning. The new technologies have given spatial solutions in the last few years. The innovative, understanding, attractive cartographical digital products present the geomorphology of the traditional villages in Cinque Terre.
A review on suitable eco-friendly earth sustainable construction building material
Authors: Asif Muhammad , Siddique Mohammad , Khan Ghulam Mustafa , Sahito Abdul Munim , Suri Saadatullah Khan , Tayyab Sayed , Karamat Nazia
Published: April 2024

This paper summarizes research on environmentally friendly and low embodied energy construction materials. Embedded electricity is defined and addressed in terms of building running power, and its significance is increasing as a result the Energy Buildings Performance Directive (EBPD) adoption in the European continent, for instance. The problems of calculating Energy that is embodied through comparison of current data are examined, along with a concrete instance of a novel approach presented in different literature. The link between embodied energy and embodied CO2, also known as carbon footprint, is illustrated. The literature discusses a wide range of low-carbon materials, including concrete and cement, as well as hardwood, stones, rammed earth, and even brickwork. The study focuses on prior research efforts to create new substances with lower contained power. To conclude, the research investigates the effects of material substitution on a building’s internal energy.
Mapping the future of antimicrobial use data collection in US animal agriculture: insights from FDA-funded pilot studies
Authors: Huebner Katherine L. , Nevius Anna , Chamberlain Julia , Bright-Ponte Susan J.
Published: April 2024

Antimicrobial use (AMU) contributes to the emergence of antimicrobial resistance, necessitating antimicrobial stewardship actions across all sectors using a One Health approach to preserve antimicrobial effectiveness. This overview delves into 2 FDA-funded projects focused on collecting and analyzing AMU data in major food-producing animal species (cattle, swine, turkeys, and chickens). Initiated in 2016, the projects aimed to establish baseline AMU information and pilot methodologies. This article describes the methodologies used by grantees for data collected from 2016 to 2021, emphasizing the diverse data sources and metrics utilized. Instead of summarizing the trends, it provides a list of publications generated from the grants. Factors contributing to successful data collection included early interaction and trust building between the producers/data holders and researchers. Shared challenges include limitations stemming from convenience sampling, variable industry participation, and lack of data covering all segments of a particular commodity (eg, data on breeding or young animals were lacking). Future collaborative efforts are needed to enhance data standardization, contextualization, representativeness, and reporting of national-scale AMU data going forward. Addressing these challenges and data gaps is essential for effective monitoring of AMU in veterinary settings and animal agriculture, in alignment with national strategies to combat antimicrobial resistance.
Understanding the Detrimental Effects of Heavy Metal Pollution in Shrimp Farming and Treatment Methods – A Review
Authors: Derrick Asare , Yohana Mpwaga Alatwinusa , Yudong Zheng , Gongyu Li , Tan Beiping , Zhang Shuang
Published: April 2024

High levels of heavy metals in the environment pose a significant risk to the aquatic ecosystem and its organisms. The non-biodegradable nature and lengthy persistence of heavy metals in the environment lead to toxicity in shrimp. Using aquatic animals as bio-indicators of metal contamination provides valuable data on acute and chronic toxicity in aquatic species and environmental quality. This review aims to provide insights into the sources, impacts, diseases and mitigation strategies related to heavy metal pollution in shrimp farming and the dangers to humans. Shrimp growth and development at each stage exhibit distinct responses to toxicity, which can vary depending on the species, types of metals, their mechanisms of action, as well as the concentration of heavy metals and duration of exposure. While several heavy metals are considered essential nutrient elements that enhance shrimp growth and feed efficiency, exceeding the maximum tolerable limit threatens shrimp health, human consumers, and ecological systems’ stability. Shrimp species subjected to lethal toxic metal concentrations experience significant effects on accumulation in histopathology. Heavy metal toxicity has been linked to high mortality rates, malformation rates, oxidative stress, moulting issues, and decreased reproduction with increasing concentrations in shrimp. Various methods have been reported for removing heavy metal ions from aquatic environments, including filtration, adsorbents, removal efficacy, operating conditions, and the pros and cons of each technique. Therefore, this review provides an overview of how heavy metals can affect shrimp physiology and dangers to consumers. It aims to increase awareness about the importance of preventing and regulating their contamination in aquatic environments.
Effect of saline water on the vase life of Narcissus poeticus L. flowers
Authors: Jezdinský Aleš , Slezák Katalin Jezdinská , Vachůn Miroslav , Pokluda Robert , Uher Jiří
Published: April 2024

The vase life of Narcissus poeticus flowers collected at the white bud stage was investigated in 13 different concentrations of NaCl (0–5–10–15–20–30–40–…–100 mM). Every 12 hr, the opening stage of the flowers was recorded, divided into 4 main categories (bud, opening flower, full open (FO) flower and wilting flower) and 14 subcategories. The salinity did not affect the flower opening speed, diameter or weight. The duration of the full flowering stage decreased from 92 hr to 44 hr, the sum of the daily ornamental value score (OVS) decreased from 120 by 3 scores per each 10 mM concentration increase. The scape chlorophyll content increased at low salinity (10–15 mM) and then decreased significantly. The carotenoid content in the scapes of wilted flowers increased in 30–100 mM solutions compared to the values in the flowering stage and flowers grown at lower salt concentrations. The Na and Cl contents in the plant parts increased significantly with the increase in salinity (at the end of the experiment, 100 mM NaCl: scapes: 44.1 g · kg-1 and 67.2 g · kg-1 Na and Cl; flowers: 16.8 g · kg-1 and 24.8 g · kg-1 Na and Cl, respectively). There was an inverse correlation between the Na and K contents in the scapes. The EC value of the vase solutions decreased during the experiment.
Sheath Tip Radial Artery Disruption as a Mechanism for Forearm Hematoma: Insights from the Distal Radial Artery Approach
Authors: Olaru Magda-Madalina , Lim Pitt O
Published: April 2024

Introduction

Radial artery occlusion (RAO), Forearm Hematoma (FH), and compartmental syndrome are three well-recognized complications associated with radial artery (RA) access to percutaneous coronary intervention (PCI). There are disparate ways the RA can be damaged, from multiple needling attempts to adverse interactions between the radial sheath, exchange wire, and diagnostic or guiding catheter with the artery.

Case presentation

We describe a 49-year-old man who had PCI through his right distal RA (dRA) with a straightforward needle puncture, followed by placement of a Terumo® 10cm 6Fr Glidesheath Slender™. After primary PCI to the right coronary artery, right FH developed, but there was neither swelling at the dRA area nor in the hand. He had staged PCI to the left circumflex artery a few days later, and a radial arteriogram was performed using the same access site. This revealed a “circumferential dissection” in the RA, which was likely to have been caused by the tip of the initial radial sheath.

Conclusion

Hypothetically, the radial sheath can systematically traumatize the RA. It may be the common denominator for RA disruption, RA thrombosis, RAO, FH, and compartmental syndrome in a continuum. Urgent radial arteriography, whenever post-procedural FH is detected, allows for the source of forearm bleeding to be determined and addressed. Trialing this strategy against current watchful conservative management is warranted.
Acetaminophen overdose treatment in patients admitted to two tertiary centers in Oman, variation and pitfalls
Authors: AL-Balush Fatma , Al-Jumma Saad , Al-Masroori Salim , Al-Abri Suad
Published: April 2024

Acetaminophen overdose treatment in patients admitted to two tertiary centers in Oman, variation and pitfalls
Validity of Using Still Images for Written Competency Assessments for Point-of-Care Ultrasound among Non-Radiologists-pilot study.
Authors: Almemari Ayesha , Buhumaid Rasha
Published: April 2024

Background and Objective:
Point-of-care ultrasound (POCUS) has become an integral part of the curricula of various spe-cialty residency programs. POCUS education requires learners to be proficient in image acqui-sition, image interpretation, and integration into clinical practice. The assessment of POCUS skills and competency is variable. This study aimed to assess the validity and reliability of us-ing still ultrasound images as examination test items without providing clinical vignettes or anatomical locations.
Methods:
This is a proof-of-concept survey pilot study, residents from the Middle East who had com-pleted their training in emergency medicine were surveyed during their competency assess-ment examination. They were provided with a single ultrasound image of an abdominal aortic aneurysm in both print and PowerPoint slide format. The task was to identify the diagnosis based on this image, which was taken from a reference emergency medicine textbook.
Results:
The study showed that only 50% of the residents correctly identified the diagnoses based on the still images. Many of the incorrect answers included diagnoses that were not related to the anatomical structure that was scanned, indicating that the residents were not able to identify the anatomical locations, which highlighted the challenges of interpreting a single still image without clinical context and emphasized the need for valid and reliable test items in point-of-care ultrasound (POCUS) education and assessment.
Conclusions:
National and international emergency medicine societies should establish standards for writ-ing POCUS examination test items to ensure their validity and reliability.
Atypical Presentation of Meningoencephalitis in an Infant Caused by Meningococcemia and Complicated by Ventriculitis with Bilateral Extra Axial Septated Collection
Authors: Alkhurayji Abdullatif , Almoffarreh Haitham , Alafandi Dina , Ghous Atheer , Abdalla Leena , Alshahrani Mohammed
Published: April 2024

Background: The diagnosis of meningitis in the infancy period is a challenging. Clinical evaluation and high index of suspicion with early empirical treatment guidelines continue to evolve and support physician efforts to decrease the morbidity and mortality associated with pediatric meningitis.
Case report: We report a case of a previously healthy 2-month-old male who presented with excessive crying, preceded by subjective fever and watery diarrhea, for one day without any other symptoms. Parents gave multiple antipyretic doses at home for irritability which might mask his fever. The patient was tachycardic with an unremarkable physical exam. Full septic work-up done after stabilization of the patient and empirical antibiotics started. His blood culture grew Neisseria meningitides which caused meningoencephalitis and ventriculitis with bilateral extra-axial collection, the patient was in septic shock with multiple organ dysfunction.
Conclusion: Meningococcal meningitis in the neonatal and infancy periods remains a serious health threat with high morbidity and mortality. This case report urges the physician to keep a high index of suspicion by taking detailed history and frequent assessment in each suspected cases as the clinical presentations, signs and symptoms in the infancy period are not specific nor classic to guide the physician.
MENINGOTHELIOID NODULES COEXISTING WITH PULMONARY HYDATID CYST:A RARE CASE REPORT
Authors: Özdüzgün Polat Sevdenur , Bayazıt Gözüküçük Buse , Yılmaz Emre , Ağaçkıran Yetkin
Published: April 2024

Meningothelioid nodules are rare and usually benign pulmonary nodules. We present this case report because it represents the first reported case of an association between meningothelioid nodules and a pulmonary hydatid cyst.
A 48-year-old Turkish female patient presented with a cough and hemoptysis lasting for a week. Chest computed tomography images revealed a well-circumscribed, unilocular cystic lesion in the left lower lobe of the lung, displaying the typical “double- wall sign” of a hydatid cyst. It was decided that the patient would undergo thoracoscopic wedge resection of the hydatid cyst in the left lower lobe. Microscopic examination revealed multiple perivenular nodules composed of epithelioid cells with round to oval nuclei, a moderate amount of eosinophilic cytoplasm, and finely granular chromatin in hematoxylin-eosin sections. Whorling of tumor cells was observed focally in most areas. Some cells exhibited pseudonuclear inclusions. The surrounding lung parenchyma contained hydatid cysts. Based on these histopathological and immunohistochemistry findings, a diagnosis of a meningothelioid nodule and a hydatid cyst was made.
We encountered a rare case of coexisting meningothelioid nodules and a pulmonary hydatid cyst. Careful pathological, clinical, and radiological examination are required for the definitive diagnosis of meningothelioid nodules, and they can provide an excellent prognosis with surgery.
Los seminarios de inmersión total en una lengua extranjera dentro de un enfoque comunicativo
Authors: De Valencia Gabriela C.
Published: April 2024

Resumen
Movimientos a distancia (una primera materialización)
Authors: Barón Sergio
Published: April 2024

Movimientos a distancia revela las contradicciones en la forma cómo han sido archivadas las imágenes de los hermanos Acevedo, pioneros del noticiero cinematográfico en Colombia. Contradicciones como la aleatoriedad con la que fueron reeditadas en los catálogos oficiales, o las lecturas que los archivadores impusieron sobre ellas; una postura oficial que confunde imágenes de muerte con imágenes de movilizaciones sociales. ¿Cómo introducir en ese relato que asocia a la protesta con la muerte la imagen profana de un carnaval? Al responder esto, el proyecto propone una forma de reeditar la historia oficial para cambiar sus finales, para esbozar futuros posibles.
ANALISIS STRATEGI PENGELOLAAN USAHA MIKRO BERBASIS APLIKASI TEKNOLOGI TEPAT GUNA HASIL INOVASI RISET DALAM UPAYA MENINGKATKAN EKSISTENSI PRODUK YOGHURT (STUDI KASUS PADA USAHA MIKRO YOGHURT SEHATI)
Authors: Naufalin Rifda , Wicaksono Rumpoko , Bawono Icuk Rangga , Supriyanti Retno
Published: April 2024

Pengabdian masyarakat merupakan salah satu Tri Dharma Perguruan Tinggi yang dilakukan untuk memberikan kontribusi kepada masyarakat luas. Program pengabdian kepada masyarakat ini bertujuan untuk membantu melakukan dan menentukan strategi pengelolaan dan pengembangan Usaha Mikro Kecil dan Menengah (UMKM) yang mandiri secara ekonomi dan sosial melalui penerapan aplikasi teknologi tepat guna hasil dari inovasi riset yang telah dilakukan. Permasalahan yang menjadi fokus dalam penerapan program pengabdian masyarakat ini adalah bagaimana cara kelompok usaha yoghurt drink dapat menerapkan teknologi diversifikasi yoghurt drink, bagaimana penggunaan kemasan produk yoghurt drink yang bagus, dan bagaimana cara meningkatkan kapasitas pengelolaan usaha melalui kapasitas pemasaran produk secara offline dan online. Untuk meningkatkan keberlanjutan usaha melalui eksistensi produk di pasaran dilakukan dengan metode penerapan teknologi tepat guna modern berskala sedang dalam proses produksi, penerapan teknologi diversifikasi produk melalui yoghurt drink rempah dari ekstrak bunga kecombrang dan berbagai varian rasa teh bunga kecombrang yang mana produk tersebut merupakan hasil-hasil riset dari riset yang telah dilakukan sebelumnya sekaligus penerapan kemasan produk yang lebih bagus untuk menjaga kualitas dari produk yoghurt yang dikemas sekalian sebagai ajang untuk menarik lebih banyak konsumen. Selain itu, dilakukan pula pelatihan dan penyuluhan mengenai proses pengolahan yoghurt kecombrang, Good Manufacturing Practice (GMP) tentang produk olahan yoghurt kecombrang, strategi pemasaran produk yang efektif secara offline dan online sehingga dapat menjangkau market yang lebih luas, dan pencatatan keuangan yang efisien melalui preferensi konsumen. Hasil dari program pengabdian masyarakat ini mampu meningkatkan manajemen pengelolaan usaha mikro UMKM Yoghurt Sehati secara lebih efektif dan efisien untuk jangka waktu yang panjang dalam upaya untuk meningkatkan nilai ekonomi atau daya jual dari produk yoghurt drink kecombrang melalui kapasitas pemasaran produk dengan metode pemasaran online dan offline secara lebih efektif dan kompetitif dengan produk lain di pasaran.
Deprivatization: current judicial practice
Authors: Gurchenko Evgenii Viktorovich , Kevorkova Diana Ashotovna
Published: April 2024

The article considers the legal framework and trends of judicial practice in claims for the recovery of previously privatized assets. The purpose is to identify risk factors for the deprivatization of enterprise property, as well as circumstances affecting the prospects of possible litigation. The authors used such research methods as logical, theoretical-prognostic, formal-legal, system-structural and legal modeling methods. The methodological apparatus consists of the following dialectical techniques and methods of scientific cognition: analysis, abstraction, induction, deduction, hypothesis, analogy, synthesis, typology, classification, systematization and generalization. The authors analyzed relevant legal cases within the context of legal regulation and doctrinal approaches to the interpretation of civil legislation. It is concluded that violation of the privatization procedure means the absence of the will of the public owner to property alienation. As a result, the public owner has the opportunity to claim property even from a bona fide purchaser. Shares in the authorized capital of companies, and individual objects (buildings, structures, movable property) are subject to deprivatization. The basis for the claim of property in favor of the state is most often the privatization of property classified as federal property, with the approval of only regional authorities as well as the privatization of property in respect of which prohibitions and restrictions are established. It is stated that the courts reject references to the expiration of the limitation period, at the same time, judicial practice regarding the application of objective limitation periods has only begun to form. Considering the specifics of the participation of public legal entities in civil turnover, the authors conclude that it is necessary to clarify the established practice of applying law by the Constitutional Court of the Russian Federation.
Intervenciones educativas sobre nutrición y actividad física en población infantojuvenil: una revisión sistemática
Authors: Arvelo Rodríguez Yaiza María
Published: April 2024

The numbers of overweight and obese children and young people are on the rise despite efforts to curb this condition. One of the measures to try to alleviate this condition is the implementation of educational intervention programs. This review aims to analyze the effectiveness of educational interventions aimed at the treatment of overweight and obesity in children and adolescents. A literature search was carried out in three databases: PubMed, Cochrane and CINALH. The selected studies were 20 and their interventions focused on the modification of eating habits, physical activity and behaviour modification in different areas. The heterogeneous characteristics of the interventions make it difficult to find the most effective one. However, the classical approach based on nutrition and physical activity may be useful but is insufficient to address this condition which is influenced by multiple contexts and factors.
VIOLÊNCIA OBSTÉTRICA NOS PRESÍDIOS FEMININOS
Authors: Danemann Mariana , Cunha Martins Sheila , Dos Santos Siqueira Thiago
Published: April 2024

Ao analisar a situação das unidades prisionais no Brasil, a precariedade e superlotação, faz-se pertinente a preocupação com as penitenciárias femininas, em especial com as mulheres grávidas encarceradas. A falta de médico e condições básicas tanto para a mãe quanto para a criança, além da violência obstétrica que as gestantes reeducandas são submetidas demonstram a invisibilidade que o Estado tem com a população prisional feminina. A questão discutida no presente artigo perpassa pelas garantias e direitos inerentes a mulher grávida, tal como às mulheres grávidas encarceradas, analisando também os direitos do bebê e do nascituro que acabam sofrendo a punição de maneira indireta e a violência obstétrica ocasionada pela falta de fiscalização e negligência do Estado. Buscou-se compreender as seguintes problemáticas: quais são os direitos da mulher grávida encarcerada, do nascituro e do bebê? Se há alguma proteção a eles, na prática está sendo cumprida ou violada? Há algum tratamento especial para as grávidas encarceradas? Existe ocorrência de violência obstétrica no sistema prisional brasileiro? Para isto, foi utilizado a metodologia revisão bibliográfica, a fim de analisar o problema da violação dos direitos da gestante encarcerada, do nascituro e do bebê, assim como a ocorrência de violência obstétrica, tendo base em outros estudos. O estudo demandou uma abordagem mista, tanto para análise dos dados escritos, quanto para a interpretação do fenômeno estudado com dados quantitativos da Secretaria Nacional de Políticas Penais. Tendo também um caráter exploratório, com levantamento de artigos em sites como a SciELO, livros de autores renomados como Pontes de Miranda, Flávio Tartuce e Nana Queiroz, assim como pesquisas de dados da Defensoria Pública a fim de chegar a conclusões concretas.
PRECEDENTES NO CÓDIGO DE PROCESSO CIVIL 2015
Authors: Ketelyn Pereira dos Santos Sara , Cunha Ferreira Israel , Dos Santos Siqueira Thiago
Published: April 2024

O presente Trabalho de Conclusão de Curso tem como objetivo principal abordar a questão dos Precedentes Judiciais no Código de Processo Civil de 2015, analisando sua função como instrumento para a celeridade processual e a segurança jurídica. Dessa forma, o estudo aqui desempenhado, inicia apresentando as duas tradições jurídicas mais importantes para um futuro desenvolvimento do sistema de precedentes: civil law e common law. Em seguida, será demonstrado como, apesar do Brasil adotar o sistema da civil law, o constitucionalismo influenciou a adoção de mecanismos que refletem a common law. Posteriormente, serão apresentados os pontos conceituais dos precedentes judiciais, bem como a sua disposição no Código de Processo Civil de 2015. Após isso, serão examinados os princípios da segurança jurídica e celeridade processual para concluir se os precedentes judiciais vieram a colaborar com a celeridade, previsibilidade e estabilidade do direito. Diante do exposto, conclui-se que frente a morosidade judicial e a insegurança jurídica os precedentes judiciais servem como uma verdadeira garantia para os cidadãos, da efetivação dos princípios da celeridade processual e segurança jurídica. Para que fosse possível alcançar os resultados obtidos, foi adotada a metodologia exploratória, com ênfase em pesquisas bibliográficas, igualmente utilizada a metodologia documental, isso através da pesquisa qualitativa, uma vez que os resultados são baseados em percepções e análises de materiais disponíveis, sejam eles físicos ou eletrônicos.
RESPONSABILIZAÇÃO PENAL POR ATOS ILÍCITOS COMETIDOS PELOS SISTEMAS DE INTELIGÊNCIA ARTIFICIAL
Authors: Cardoso Vieira Doralice , Dos Santos Siqueira Thiago
Published: April 2024

Este trabalho tem como objetivo investigar a viabilidade da responsabilização penal por atos ilícitos cometidos por sistemas de inteligência artificial (IA). Diante da crescente presença de sistemas autônomos na vida cotidiana, surge a possibilidade de tais entidades tomarem decisões que resultem em infrações criminais. O estudo se propõe a analisar a legislação brasileira, bem como a literatura nacional e internacional, com o intuito de determinar se é possível responsabilizar criminalmente sistemas dotados de IA e quem seria responsável por essa imputação. Os objetivos específicos englobam a contextualização da inteligência artificial, sua evolução histórica e investigação sobre a imputação de responsabilidade penal a sistemas de IA, além de explorar como o Direito Penal brasileiro lida com crimes reais e hipotéticos cometidos por IA. Os resultados apontam que, de acordo com a atual definição de responsabilidade penal no Código Penal Brasileiro, a imputação de responsabilidade penal a robôs inteligentes não é viável, uma vez que apenas a conduta humana é passível de punição. Portanto, conclui-se que, apesar dos estudos internacionais sobre a responsabilidade penal de sistemas de IA, essa aplicação ainda não é possível no contexto legal brasileiro. Além disso, não se vislumbra a possibilidade de penalizar programadores e empresas criadoras de sistemas de IA, restando apenas a opção de buscar reparação civil.
Hidradenitis suppurativa: definition, epidemiology, etiology, diagnosis (part 1)
Authors: Olisova Olga Y. , Sokolovskiy Evgeny V. , Khairutdinov Vladislav R. , Kokhan Muza M. , Rakhmatulina Margarita R. , Burova Sofia A. , Kotrekhova Lubov P. , Pirogova Anna S. , Araviyskaya Elena R. , Samtsov Aleksey V.
Published: April 2024

Hidradenitis suppurativa (HS) is a chronic recurrent skin disease characterized by development of autoimmune inflammation in the infundibulum of the hair follicle and apocrine sweat glands located in the axillary, inguinal, anogenital regions, submammary folds, near the areola of mammary glands and the umbilical region. HS is difficult to treat and has an extremely negative impact on the quality of life. HS is separated into a distinct clinical entity fundamentally different in etiopathogenesis from acute bacterial hidradenitis. The exact prevalence of HS is unknown, it varies greatly in different studies ranging from 0.03 to 4% in general population. The detection of IL-1β, IL-23, and IL-17 in the lesions indicates the key role of autoimmune inflammation involving Th17-lymphocytes in the pathogenesis of HS. Risk factors include smoking, obesity, mechanical friction, genetic predisposition. The diagnosis of HS relies on three obligatory criteria: characteristic distribution, typical morphology of the lesions and relapsing, chronic disease course. There is no “gold standard” in assessing the severity of the disease, since all available scoring systems have many limitations, therefore many questions regarding this disease remain unsolved at present — from terminology and clear and most objective assessment criteria for the severity of the process to the development of native clinical guidelines.
Effect of Commonly Prescribed Medications on Osseointegration and Implant Stability
Authors: Attargekar Vikas , Kumari Abha , Dey Soumadip , Magdum Dilip
Published: April 2024

Background: Osseointegration, the process by which implants integrate with surrounding bone, is crucial for the success of dental implants. However, the impact of commonly prescribed medications on osseointegration and implant stability remains a topic of interest and concern within the field of implant dentistry. Materials and Methods: In this study, we conducted a retrospective analysis of patients who received dental implants between 2018 and 2020. Patients were categorized based on their medication usage at the time of implant placement. Medications included in the analysis were divided into groups such as bisphosphonates, corticosteroids, selective serotonin reuptake inhibitors (SSRIs), and non-steroidal anti-inflammatory drugs (NSAIDs). Implant stability was assessed using resonance frequency analysis (RFA), and osseointegration was evaluated through radiographic examination. Results: A total of 150 patients were included in the study, with 50 patients in each medication group. The mean RFA values for patients on bisphosphonates, corticosteroids, SSRIs, NSAIDs, and control group were 67, 72, 69, 71, and 75 ISQ, respectively. Radiographic evaluation revealed osseointegration rates of 80, 85, 75, 82, and 90% for the respective medication groups. Conclusion: Our findings suggest that commonly prescribed medications may have varying effects on osseointegration and implant stability. While corticosteroids and NSAIDs seem to have minimal impact, bisphosphonates and SSRIs may potentially hinder osseointegration and decrease implant stability. Clinicians should consider patients’ medication history when planning dental implant procedures and closely monitor implant integration in patients taking these medications
Amplification of Aqueous Solubility of Progesterone Using Melt-Granulation Technique
Authors: DS Bhosale , MS Kalshetti
Published: April 2024

The objective of the present research was to enhance the rate of dissolution of progesterone by boosting the hormone’s solubility in water. This research determines whether or not employing melt granulation techniques with various polymers may improve the degree to which progesterone is soluble. When looking into the interactions between drug carriers and other substances, researchers turned to techniques such as X-ray diffraction (XRD), differential scanning calorimetry (DSC), and Fourier transform infrared (FTIR). PEG 6000 (1:1.5) demonstrated the highest solubility, followed by PEG 6000 (1:1) > Gelucire 50/13 (1:1.5) > Gelucire 50/13 (1:1). Increasing the solubility of the weakly soluble progesterone was demonstrated by these findings. Melt granulation on polymers boosted progesterone’s dissolution rate, which in turn can raise oral bioavailability.
Validated Stability Indicating RP-HPLC Method for the Quantification of Process Related Impurities of Solifenacin and Mirabegron in Pharmaceutical Formulations
Authors: Patil D J , Godge R K , Jahagirdar S N , Mandhare S B
Published: April 2024

To assess solifenacin (SOL) and mirabegron (MER) simultaneously, a verified reverse-phase high-performance liquid chromatography (RP-HPLC) method has been developed to indicate stability. The method was thoroughly evaluated and found to meet satisfactory criteria for precision, linearity, accuracy, limits on detection, and robustness, limits on quantitation. The quantitation wavelength of 231 nm was determined. Linearity was successfully demonstrated across concentration ranges of 5 to 25 μg/mL of solifenacin and 50 to 250 μg/mL of mirabegron. RPHPLC separations was conducted employing a Phenomenex L. C18 column measuring 250 x 4.6 mm and containing particles as small as 5 μm. The methanol and phosphate buffer (pH 7) were combined in a volumetric ratio of 25:75 to create the mobile phase. The separation is accomplished at a 0.7 mL per minute flow rate. Time spent in retention for mirabegron and solifenacin had been established at 5.521 and 9.161 minutes, respectively. Forced degradation studies validated the stability-indicating character of the approach, which included hydrolysis under acidic and basic conditions, exposure to H2O2, thermal degradation, and photodegradation. Mirabegron and solifenacin exhibited 10 to 20% degradation under the specified conditions. Importantly, the process evaluated the two prescription drugs in detail with all degradation products generated during the forced degradation experiments. This developed method is characterized as straightforward, specific, and cost-effective, making them suitable of the simultaneous estimate of mirabegron with solifenacin in tabs dose forms.
Formulation and Evaluation of Microspheres Drug Delivery for Multiple Sclerosis Disease Condition
Authors: Jadhav Kiran K , H V Gangadharappa
Published: April 2024

AMultiple sclerosis (MS) is chronic inflammatory disease that affecting the central nervous system (CNS) which leads to the degeneration of oligodendrocytes, neurons, and myelin over time. Being the foremost reason of neurological disability multiple sclerosis has affected about 2.5 million humans around the world. MS is mainly seen in early adulthood and adults in their middle age. Disease modifying agents are being used in treatment of relapsing multiple sclerosis. Medications that reduce the severity of the disease are frequently utilized as standard therapies. The immune system is the primary focus of modern MS treatments. However, researchers are putting more effort into designing novel CNS-focused treatments. Therefore, under the current scenario, an alternative route for drug delivery is required, one that provides a speedy onset of action and then maintains the drug release over an extended period. The desired prolong-acting intramuscular injecting stable fingolimod HCl microspheres to treat MS were formulated using solvent evaporation technique. Further, based on the number of factors to be optimized, formulation was prepared using solvent evaporation. Additionally, the formulated fingolimod microspheres were characterized for the size distribution of particle, particle surface morphology, and lyophilization of formulated microspheres. Post lyophilization, the formulated microspheres evaluation was done for efficiency of entrapment, drug release in-vitro, and stability parameters. Furthermore, in-vivo studies were performed on suitable animal models for the optimized formulation.
Formulation, In-vitro and In-vivo Evaluation of Chronology-based Mucoadhesive Drug Delivery System of an Antihypertensive Drug
Authors: Janugade Bhagyesh U , Singla Neelam
Published: April 2024

Current research aimed to prepare and estimate chronology-based mucoadhesive PDDS of antihypertensive drug losartan potassium through formulation of fast-dissolving core tablet and incorporation of core tablet to polymer coating to formulate bioadhesive PDDS through direct compression system. The coating was done by using polymers ethyl cellulose and carbopol 934. Pre-compression and post-compression parameters, drug release, lag time and mucoadhesive examination was assessed for the formulation. The expected lag time for hypertension is 8 hours; hence, this lag time was achieved by using a bioadhesive pulsatile system. The optimized formulation showed 8 hours lag time with appropriate mucoadhesion for an equivalent period. Moreover, in-vitro as well as in-vivo mucoadhesion investigations reflected the positive outcomes. Consequently, the BPDDS was the finest preventative substitute for drugs with the highest absorption in the stomach and for drugs used to treat diseases related to circadian rhythm
Development and Evaluation of Polyherbal Gel for Treatment of Diabetic Neuropathy
Authors: Singh Mahaveer , Rao Desu Brahma Srinivasa , Soni Varinder , Minhas PS , Amudha S
Published: April 2024

Diabetic neuropathy is a prevalent and painful issue of diabetes mellitus, impacting a large number of people with both type 1 and 2 diabetes. Herbal formulations are found to be effective and have fewer side effects. The study aimed to create a topical polyherbal gel using ethanolic extracts and to evaluate polyherbal gel. Ethanolic extract of Curcuma longa rhizomes and Gingko biloba leaves were obtained and used to prepare different formulations of polyherbal gels using Carbopol 940 and other excipients. The developed compositions were assessed using a range of gel evaluation standards, including physical examination pH, viscosity measurement, spreadability. The in-vitro permeation study is derived from the Franz diffusion. The evaluation shows ideal results for polyherbal gel. The pH of the polyherbal gel was observed to be between 6.22 and 6.51, which is considered suitable for topical application. The polyherbal gel formulations showed ideal viscosity range and spreadability. Among the four formulations, the PG3 formulation was found to be stable.