bluuebunny/crossref_metadata_2025 huggingface dataset:
Biochemical and Behavioural Alterations Induced by Arsenic and Temperature in Hediste Diversicolor of Different Growth Stages
Authors: Valente Pedro , Cardoso Paulo , Giménez Valéria , Silva M.S.S. , Sá Carina , Figueira Etelvina , Pires Adília
Published: August 2022

Contamination with Arsenic, a toxic metalloid, is increasing in the marine environment. Additionally, global warming can alter metalloids toxicity. Polychaetes are key species in marine environments. By mobilizing sediments, they play vital roles in nutrient and element (including contaminants) cycles. Most studies with marine invertebrates focused on the effects of metalloids on either adults or larvae. Here we bring information on the effects of temperature increase and arsenic contamination on the polychaete Hediste diversicolor in different growth stages and water temperatures. Feeding activity and biochemical responses – neurotransmission, indicators of cell damage, antioxidant and biotransformation enzymes and metabolic capacity - were evaluated. Temperature rise combined with As imposed alterations on feeding activity and biochemical endpoints at different growth stages. Small organisms have their antioxidant enzymes increased, avoiding lipid damage. However, larger organisms are the most affected class due to inhibition of superoxide dismutase, which resulted in protein damage. Oxidative damage was observed on smaller and larger organisms exposed to As and 21 °C, demonstrating higher sensibility to the combination of temperature rise and As. The observed alterations may have ecological consequences, affecting the cycle of nutrients, sediment oxygenation and the food chain that depend on the bioturbation of this polychaete.
The Role of Matrix Metalloproteinase in Infectious Diseases
Authors: Lee Han Sol , Kim Woo Joo
Published: August 2022

Matrix metalloproteinases are involved in extracellular matrix remodeling through the degradation of extracellular matrix components and are involved in the inflammatory response by regulating the activities of TNF-alpha and IL-1beta, which are pro-inflammatory cytokines, in addition to extracellular matrix components. Since the regulation of inflammatory response and changes in the extracellular matrix by MMPs are related to the development of various diseases including lung and cardiovascular diseases, many studies have been conducted on the role of MMPs in pathogenesis. In addition, various studies have demonstrated that MMPs are involved in the pathogenesis of infectious diseases by regulating the expression and activity of MMPs by infection with pathogens. In this review, we discuss the role of MMPs in infectious diseases and the role of MMPs in inflammatory responses and present their potential as therapeutic targets in infectious diseases.
The University of West Florida Campus Ecosystem Study: Spatial and Temporal Variation in Water Quality at Thompson Bayou
Authors: Gilliam Frank S. , Hardin Jacob W. , Williams Jacob A. , Lackaye And Rachel L.
Published: August 2022

Stream chemistry effectively integrates watershed ecosystem processes on both spatial and temporal scales. Streams of coastal areas integrate a more homogeneous, flat topography wherein there can be interactions between the stream and the body of water into which it drains, especially where tidal fluxes occur. The present study assessed water quality of Thompson Bayou, which comes to the campus of the University of West Florida in a wetland after flowing through 4 km of commercial and private property with associated impacts on water quality. Sampling was carried out for one year at eight discrete sites along Thompson Bayou from the UWF campus to the Escambia River. We used a portable field meter to measure temperature, pH, dissolved O2 (DO), and specific conductivity (SC). Except for temperature, all variables exhibited a spatial pattern of significant variation with distance, with consistent increases in DO and SC as the stream approached the river. These variables also exhibited a temporal pattern of significant seasonal variation, including—and especially—temperature. Data suggest that spatial and temporal patterns of water quality of Thompson Bayou are determined by (1) processing of water by the wetland, (2) interactions of the stream channel with upland forest stands, and (3) the tidal hydrology of the Escambia River.
Inference of Pulmonary Arterial Pressure using Non-invasive Measurements and Scientific Machine Learning Techniques
Authors: Laubscher Ryno , Van Der Merwe Johan , Herbst Philip G. , Liebenberg Jacques
Published: August 2022

Reliable quantification of pulmonary arterial pressure is essential in the diagnostic and prognostic assessment of a range of cardiovascular pathologies including rheumatic heart disease, yet an accurate and routinely available method for its quantification remains elusive. This work proposes an approach to infer pulmonary arterial pressure based on scientific machine learning techniques and non-invasive, clinically available measurements. A 0-D multicompartment model of the cardiovascular system was optimized using several optimization algorithms, subject to forward-mode automatic differentiation. Measurement data were synthesized from known parameters to represent the healthy, mitral regurgitant, aortic stenosed and combined valvular disease situations with and without pulmonary hypertension. Eleven model parameters were selected for optimization based on 95 % explained variation in mean pulmonary arterial pressure. A hybrid Adam and limited-memory Broyden-Fletcher-Goldfarb-Shanno optimizer yielded the best results with input data including valvular flow rates, heart chamber volume changes and systematic arterial pressure. Mean absolute percentage errors ranged from 1.8 % to 3.78 % over the simulated test cases. The model was able to capture pressure dynamics under hypertensive conditions with pulmonary arterial systole, diastole, and mean pressure average percentage errors of 1.12 %, 2.49 % and 2.14 %, respectively. The relatively low errors highlight the potential of the proposed model to recover pulmonary pressures for diseased heart valve and pulmonary hypertensive conditions.
Generation of Cytotoxic T cells and Dysfunctional CD8 T Cells in Severe COVID19 Patients
Authors: Gozzi-Silva Sarah Cristina , Oliveira Luana de Mendonça , Alberca Ricardo Wesley , Pereira Nátalli Zanete , Yoshikawa Fabio Seiti , Pietrobon Anna Julia , Yendo Tatiana Mina , Andrade Milena Mary , Ramos Yasmim Álefe Leuzzi , Brito Cyro Alves , Oliveira Emily Araújo , Beserra Danielle Rosa , Duarte Alberto José da Silva , Sato Maria Notomi
Published: August 2022

COVID-19, the infectious disease caused by SARS-CoV-2, has spread on a pandemic scale. The virus infection can evolve asymptomatically or generate severe symptoms, influenced by the presence of comorbidities. Lymphopenia in patients affected with COVID-19 according to the severity of symptoms is frequent. However, the profile of CD4+ and CD8+ T-cells regarding cytotoxicity and antiviral factor expression has not yet been completely elucidated in acute SARS-CoV-2 infections. The purpose of this study is to evaluate the phenotypic and functional profile of T-lymphocytes in patients with moderate and severe/critical COVID-19. During this pandemic period, we analyzed a cohort of 62 confirmed patients with SARS-CoV-2 (22 moderate cases and 40 severe/critical cases). Albeit lymphopenia, we observed an increase in the expression of CD28, co-stimulator molecule, and activation markers (CD38 and HLA-DR) in T-lymphocytes as well as an increase in the frequency of CD4+ T-cells, CD8+ T-cells, and NK cells that express the immunological checkpoint protein, PD-1, in patients with severe/critical condition compared to healthy controls. Regarding the cytotoxic profile of peripheral blood mononuclear cells, an increase in the response of CD4+ T-cells already at baseline level was observed, scarcely changed upon PMA and Ionomycin stimulation. Meanwhile, CD8+ T-lymphocytes decreased cytotoxic response, evidencing a profile of exhaustion in patients with severe COVID-19. As observed in the t-SNE technique CD4+ T-cytotoxic and CD8+ T with low granzyme production evidencing their dysfunctionality in severe/critical conditions. In addition, purified CD8+ T-lymphocytes from patients with severe COVID-19 showed an increased constitutive expression of differentially expressed genes associated with the caspase pathway, inflammasome, and antiviral factors, and curiously, reduced expression of TNF-α. The cytotoxic profile, by CD4+ T-cells, may compensate for the dysfunction/exhaustion of TCD8+ in acute SARS-CoV-2 infection. These findings may provide an understanding of the interplay of cytotoxicity between CD4+ T-cells and CD8+ T-cells in the severity of acute COVID-19 infection.
Variables Influencing the Pressure and Volume of the Pulmonary Circulation as Risk Factors for Developing High Altitude Pulmonary Edema (HAPE)
Authors: Küpper Thomas , Apel Christian , Bertsch Daniela , Van der Giet Michael , Van der Giet Simone , Graß Maren , Gschwandtl Carina , Heussen Nikole , Kühn Christian , Hundt Miriam , Risse Julia , Schmitz Sonja , Timmermann Lisa , Wernitz Knut , Gieseler Ulf , Morrison Audry , Hundt Nina
Published: August 2022

Background: At altitudes beyond 2500 m the risk of developing high altitude pulmonary edema (HAPE) grows with the increases in pulmonary arterial pressure. HAPE is characterized by severe pulmonary hypertension, though the incidence and relevance of individual risk factors are not yet predictable. However, the systolic pulmonary pressure (SPAP) and peak in tricuspid regurgitation velocity (TVR) are crucial factors when diagnosing pulmonary hypertension by echocardiography. Methods: The SPAP and TVR of 27 trekkers aged 20-65 years en route in the Solu Khumbu region of Nepal was assessed. Echocardiograph measurements were performed at Lukla (2,860 m), Gorak Shep (5170 m), and the summit of Kala Patthar (5,675 m). The altitude profile and the participant’s characteristics were also compiled for correlation with the measured data. Results: The results showed a highly significant increase of SPAP and TVR after ascending Kala Patthar. The study revealed a lower increase of SPAP and TVR in the group of older participants, although the initial respective measurements in Gorak Shep were significantly higher for this group. A similar finding occurred in those using Diamox® as prophylaxis. There was an inverse relationship between TVR and SPAP, the peripheral capillary oxygen saturation and heart rate. Conclusions: The echocardiograph results indicate that older people are a risk group for developing a HAPE. The prophylactic use of acetazolamid led to higher initial SPAP values in Gorak Shep, and a lower increase of SPAP as well as TRV after ascending Kala Patthar. Arterial oxygen saturation measurements can provide an indicator for the self-assessment for the risk of developing HAPE and provide a rule of thumb for the altitude profile but does not replace a HAPE diagnosis. The collected data variables concerning backpack weight, sex, workload (actual ascent speed), and pre-existing diseases were not statistically significant factors related to SPAP and TVR (p=<0.05).
Experimental Proof-Of-Concept of a Spatial Photonic Switch Based on an Off-Axis Zone Plate in Millimeter Wavelength Range
Authors: Paulish Andrey G. , Geints Yury E. , Minin Oleg V. , Minin Igor V.
Published: August 2022

Optical switches are a key element in modern network communications. We present the results of experimental verification of a new theoretical concept proposed earlier for a full-optical wavelength-selective dual-channel switch based on the photonic hook effect, which is free from using any micro-mechanical devices or nonlinear materials. A large-scale laboratory prototype of such a device based on an off-axis Wood zone plate is considered and its main parameters in the millimeter wavelength range are investigated On the basis of the experiments, we show that the optical isolation of switched channels for a switch based on an off-axis zone plate can achieve 15 dB at a frequency difference of 25 GHz in frequency range from 93 to 136 GHz. Given the scaling, these results can be transferred to another range, including the optical one.
Aconitum Alkaloid Songorine Exerts Potent Gamma-aminobutyric Acid A Receptor Agonist Action In Vivo and Effectively Decreases Anxiety Without Adverse Sedative or Psychomotor Effects in the Rat
Authors: Bali Zsolt Kristóf , Bruszt Nóra , Kőszegi Zsombor , Nagy Lili Veronika , Atlasz Tamás , Kovács Péter , Csupor Dezső , Csupor-Löffler Boglárka , Hernádi István
Published: August 2022

Songorine (SON) is a diterpenoid alkaloid from Aconitum plants. Preparations of Aconitum roots have been employed in traditional oriental herbal medicine, however, their mechanisms of action are still unclear. Since GABA-receptors are possible brain targets of SON, we investigated which subtypes of GABA-receptors contribute to the effects of SON, and how SON affects anxiety-like trait behavior and psychomotor cognitive performance of rats. First, we investigated the effects of microiontophoretically applied SON alone and combined with GABA-receptor agents picrotoxin and saclofen on neuronal firing activity in various brain areas. Next, putative anxiolytic effects of SON (1.0-3.0 mg/kg) were tested against the GABA-receptor positive allosteric modulator refer-ence compound diazepam (1.0-5.0 mg/kg) in the elevated zero maze (EOM). Furthermore, basic cognitive effects were assessed in a rodent version of the psychomotor vigilance task (PVT). Local application of SON predominantly inhibited the firing activity of neurons. This inhibitory effect of SON was successfully blocked by GABA(A)-receptor antagonist picrotoxin but not by GABA(B)-receptor antagonist saclofen. Similar to GABA(A)-receptor positive allosteric modulator diazepam, SON increased the time spent by animals in the open quadrants of the EOM without any signs of adverse psychomotor and cognitive effects observed in the PVT. We showed that, under in vivo conditions SON acts as a potent GABA(A)-receptor agonist and effectively decreases anxiety without observable side effects. The present findings facilitate the deeper understanding of the mechanism of action and the widespread pharmacological use of diterpene alkaloids in various CNS indications.
Development and Validation of UPLC-Qtof-MS Method for Blood Analysis of Amphetamine-Related Drug Isomers
Authors: Alamir Ahmad , Watterson James , Attafi Ibraheem
Published: August 2022

Abuse of amphetamine-related drugs (ARDs) causes traffic accidents, violence, and overdose. In forensic toxicology, analysis for ARDs in biological samples can help identify those driving or performing other tasks under the influence of drugs, clarify the cause of death, and identify recent drug users. In this study, we validated a pseudo-isocratic UPLC-qTOF-MS method following mixed mode cation exchange (MMSPE) extraction for analysis of ARDs in blood. The procedure requires 250 μL of blood to achieve a limit of quantification (LOQ) and detection (LOD) of 20 ng/mL for all analytes. In aged animal blood samples, extraction recoveries of 63-90% and matrix effects of 9-21% were observed. Precision and accuracy for all analytes were within 20% and 89–118%, respectively. The analytical method was developed and validated in accordance with the Scientific Working Group for Forensic Toxicology (SWGTOX) Standard. It has acceptable accuracy and precision for use in doping control and forensic toxicology.
Bi-Directional Associations of Affective States and Diet among Low-Income Hispanic Pregnant Women using Ecological Momentary Assessment
Authors: Mason Tyler B , Wang Wei-Lin , Bastain Theresa , O'Connor Syndey , Cabison Jane , Naya Christine H. , Chu Daniel , Eckel Sandrah P , Habre Rima , Breton Carrie V. , Dunton Genevieve
Published: August 2022

Background: Affective states play a role in dietary behaviors. Yet, little research has studied within-subjects associations between affect and diet during pregnancy. We examined the acute bidirectional relationships between affect and food intake and moderation by pre-pregnancy body mass index (BMI) in low-income, Hispanic pregnant women using ecological momentary assessment (EMA). Methods: Women (N=57) completed four days of EMA during their first trimester. Women responded to five random prompts per day about their current affect and past two-hour food intake. Results: Higher positive affect (PA) or lower negative affect (NA) predicted greater likelihood of fruit/vegetable consumption in the next two hours in women with lower pre-pregnancy BMI and lower likelihood in women with higher pre-pregnancy BMI. Higher PA predicted less likelihood of fast food consumption in the next two hours in women with lower pre-pregnancy BMI and slightly higher likelihood in women with higher pre-pregnancy BMI. Women with lower pre-pregnancy BMI had higher PA when they reported consuming chips/fries in the past two hours, and women with higher pre-pregnancy BMI had lower PA when they reported consumption of chips/fries in the past two hours. Conclusions: Results showed differential relationships between affect and food intake as a function of pre-pregnancy BMI.
Evaluation of a Sleep Education Workshop for Trainee Psychologists Designed to Increase Knowledge and Practical Skills in Sleep and Insomnia Management: A Pilot Study
Authors: Meaklim Hailey , Rehm Imogen C , Junge Moira F , Monfries Melissa , Kennedy Gerard A , Bucks Romola S. , Meltzer Lisa J , Jackson Melinda L
Published: August 2022

Despite the strong links between sleep, circadian rhythms, and mental health, sleep education has been neglected in mental healthcare provider training programs. The current pilot study examined the potential efficacy and acceptability of a sleep education workshop for trainee psychologists, called the Sleep Psychology Workshop. Eleven students completing their Master of Psychology degrees (90% female, 24.4 ± 1.6 years old) attended the Sleep Psychology Workshop as part of their Health Psychology course, delivered as three, two-hour lectures (total six hours). Trainees’ sleep psychology knowledge quiz scores (% correct) demonstrated significant improvement from pre- (M = 60%, SD = .09) to post-workshop (M = 79%, SD = .08), t (6) = -5.18, p = .002. Trainees also reported increased self-efficacy to use common sleep-related assessment instruments and empirically supported interventions to manage sleep and circadian rhythm disturbances, along with increased confidence to manage insomnia disorder in clinical practice (all p<.02). Trainees also endorsed the workshop as an acceptable sleep education program for trainee psychologists via a post-workshop feedback survey, focus group, and six-month follow-up survey. This pilot study provides preliminary evidence for the Sleep Psychology Workshop as an effective and acceptable sleep education program for trainee psychologists.
Impacts of Land-Use and Climate Changes on Hydrologic Processes in the Piracicaba Basin, Brazil
Authors: Machado Ronalton , Sentelhas Paulo , Leite Rafael
Published: August 2022

Climate and land use changes are two factors affecting the hydrology of watersheds. The greatest effect of climate change is probably the change in the hydrological cycle, thus water availability for human consumption, industry, and power generation. While the change in land use can cause changes in the hydrological components of the basin, such as evapotranspiration, runoff, and groundwater recharge. From these projections, it is necessary to understand the processes involved in climate change and land use and its impact on water systems. In this context, the objective of this study was to simulate climate change scenarios combined with the land use change and to analyze the impacts on the hydrology in the Piracicaba basin. Two periods were selected based on the preliminary result of detection of the abrupt change point of the annual flow series, using Petitt's non-parameter test. The first period selected prior to the occurrence of the point of the change was from 1985 to 2000. The other period after the point of the change was 2001 to 2015. Land use maps of the years 1990 and 2010 were used to represent the two periods. The results showed a good performance of the SWAT model. The NS (Nash-Sutcliffe coefficient) was 0.88 in calibration for both periods. In the validation, the NS was 0.92 and 0.94 for the first and second periods respectively. We then simulate climate and land use changes scenarios and compare them to the current scenario (baseline). The simulation results showed that the hydrological processes in the Piracicaba basin in the period 1985-2015, had more intense responses to land use change than climate.
Using FTA Cards as a Rapid and Field Tool for Detection and Serotyping of Foot-and-mouth Disease Virus in Libya
Authors: Abosrer Fadila , Kraim Elfurgani , Brocchi Emiliana , Pezzoni Giulia , Grazioli Santina , Dayhum Abdunaser , Eldaghayes Ibrahim
Published: August 2022

Foot and Mouth Disease (FMD) is a viral disease, widespread and highly contagious affecting mainly cloven-hoofed domestic and wild animals. FMD can lead to high economic losses due to reduction in animals’ production such as drop of milk production, loss of body weight and high mortality rate in young ruminants. Sixteen nasal swabs and epithelial tissues were collected from animals showing typical clinical signs of FMD during the last FMD outbreak in Libya in 2018-2019. Blood samples, swabs and epithelial tissues impressions on Flinders Technology Associates (FTA) cards were shipped to the FMD Reference laboratory in Brescia, Italy, and tested for the detection of FMD viruses. Nucleic acids were extracted from the FTA cards and molecular testing of the examined FTA cards confirmed that the FMD virus circulating in Libya was serotype O. Sequencing analysis of the FMD virus VP1 gene confirmed that FMD virus strain was serotype O/East Africa 3 (O/EA-3) topotype. The phylogenetic of the VP-1 gene of the FMD virus showed very high nucleotide identity (99.8%) between the virus circulating in Libya and the Algerian FMD virus strains isolated in Algeria on 2018 and 2019.
Interventions for Continuity of Essential Health Service Delivery during the COVID-19 Response in Uganda, between March 2020 and April 2021
Authors: Kabwama Steven Ndugwa , Wanyenze Rhoda K. , N Kiwanuka Suzanne , Namale Alice , Ndejjo Rawlance , Monje Fred , Wang William , Lazenby Siobhan , Kizito Susan , Troeger Christopher , Liu Anne , Lindgren Helena , Razaz Neda , Ssenkusu John , Sambisa William , Bartlein Rebecca , Alfvén Tobias
Published: August 2022

Introduction: The COVID-19 pandemic overwhelmed health systems globally, and affected delivery of other health services. We conducted a study in Uganda to describe interventions for continuity of access to other health services. Methods: We reviewed documents and interviewed 21 key informants. Thematic analysis was conducted to identify themes using the World Health Organization health system building blocks as a guiding framework. Results: Governance strategies included establishment of coordination committees and development and dissemination of guidelines. Infrastructure and commodities strategies included review of drug supply plans and allowing emergency orders. Workforce strategies included provision of infection prevention and control equipment, recruitment and provision of incentives. Service delivery modifications included designation of facilities for COVID-19 management, patient self-management, dispensing drugs for longer periods and leveraging community patient networks to distribute medicines. However, multi-month drug dispensing led to drug stock-outs while community drug distribution was associated with stigma concerns. Conclusions: Health service maintenance during emergencies requires coordination to harness existing health system investments. The service continuity committee coordinated efforts to maintain services and should remain a critical element of emergency response. Self-management and leveraging patient networks should address stigma to support service continuity in similar settings and strengthen service delivery beyond the pandemic.
Historic and Prehistoric Epidemics: An Overview of Sources Available for the Study of Ancient Pathogens
Authors: Van der Kuyl Antoinette Cornelia
Published: August 2022

Since life on earth developed, parasitic microbes have thrived. Increases in host numbers, or the conquest of a new species, provides an opportunity for such a pathogen to enjoy, before host defense systems kick in, a similar upsurge in reproduction. Outbreaks ‒ caused by ‘endemic’ pathogens ‒ and epidemics ‒ caused by ‘novel’ pathogens ‒ have thus been creating chaos and destruction since prehistorical times. To study such (pre)historic epidemics, recent advances in the ancient DNA field, applied to both archeological and historical remains, have helped tremendously to elucidate the evolutionary trajectory of pathogens. These studies offered new and unexpected insights in the evolution of, for instance, smallpox virus, hepatitis B virus and the plague-causing bacterium Yersinia pestis. Furthermore, burial patterns and historical publications can help in tracking down ancient pathogens. Another source of information is our genome, where selective sweeps in immune-related genes relate to past pathogen attacks, while multiple viruses have left their genomes behind for us to study.
Prevalence of Human Herpesviruses (HHV1-7), and its Clinical Significance in Middle Eastern Pediatric Leukemia Patients Using 2 Independent PCR Assays
Authors: Mohamed Waleed Seif ElDin , Aldabbagh Hisham Abid , Aldughmani Hussein Ali , Abdullah Zeinab Fathy , Kassem Sara Ahmed , Abdel-Almoniem Iman Adel , Ibrahim Mohamed Fawzy
Published: August 2022

Objectives: Human herpes viruses can cause life-threatening diseases in immunocompromised children, especially leukemic patients. Therefore, the aim of this study is to detect the human herpes viruses (HHV1-7) and to investigate its clinical significance in Middle Eastern Pediatric Leukemia Patients by using 2 Independent PCR assays. Methods: Detection of human herpes virus DNA has been done in blood samples of 200 pediatric leukemia patients in addition to 90 blood donors as a control group using multiplex PCR assays. When a ‘‘positive’’ result was observed, real-time PCR was performed to measure the viral load. Results: The most frequent herpes virus infection in Middle Eastern Pediatric Leukemia cases was CMV, followed by EBV, then HHV6, VZV, HHV7, HSV1, and HSV2, where they were 92/200 (46%), 76/200 (38%), 72/200 (36%), 48/200 (24%), 12/200 (6%), 8/200 (4%), and 2/200 (1%) respectively. Also, there was a statistically significance difference between leukemic patients and their controls regarding CMV, EBV, HHV6, and VZV (P <0.05). Correlation between percentage of co-infection, and clinical parameters for the 7 herpes viruses has been studied, and there is an increase in absolute neutrophilic count (ANC), total leukocyte count (TLC) and duration of fever and neutropenia in age group 6-11 years for HHV6/CMV, then in age group 12-18 years especially for EBV/CMV and CMV/HHV6. Also, our results show that multiplex PCR assay is close to single PCR assay in relation to specificity and sensitivity which in turn prove its validity for early diagnosis of herpes viral infection. Conclusions: Adopting multiplex PCR technique is helpful in screening of virus infections. It will save time, effort, cost effective and will assist in rapid diagnosis. However, the clinical relevance of the virus infection needs to be evaluated by quantitative real-time PCR which in turn will help patient's management by using appropriate antiviral treatment.
Production efficiency in handicrafts manufacturing on the example of decorative ceramics: the use of training for making craft products made of glass fiber reinforced concrete
Authors:   Indonesian Institute of the Arts Yogyakarta, Raharjo Timbul , Sudiyati Noor ,   Indonesian Institute of the Arts Yogyakarta, Jayadi Nor ,   Indonesian Institute of the Arts Yogyakarta, Sukanadi I Made ,   Indonesian Institute of the Arts Yogyakarta, Ratnaningtyas Yohana Ari ,   Indonesian Institute of the Arts Yogyakarta
Published: August 2022

This study aims to determine the benefits of training in making decorative pots with GFRC material to increase production time efficiency. The glass fiber reinforced concrete (GFRC) is a material technology in the manufacture of handicrafts using a mixture of cement, milk, and glass fiber. Training to make handicrafts from GFRC material is one alternative to increase the efficiency of ornamental pot products. This study used the descriptive qualitative method. The research was carried out in a special area of Yogyakarta by involving 20 members of the Indonesian Furniture and Handicraft Industry Association (ASMINDO) Yogyakarta. Data were obtained by direct observation of the training activities carried out. The data were analyzed using the Miles and Huberman model, namely data reduction, tabulation, data presentation, and concluding. The results showed that the training was carried out by considering the curriculum, training materials and methods, experimental processes, and production efficiency. Participants were able to make four new pot models according to the trend of craft product design. New models and manufacturing methods can be used as a reference to produce shapes and finishes. The participants felt the benefits and applied this technique in the craft production process. Therefore, the effectiveness of productivity and the economy and welfare can be increased in MSMEs in Yogyakarta.
How to improve the quality of accounting information system in digital era (an empirical study of state-owned enterprises in Indonesia)
Authors:   Padjadjaran University, Anggraeni Annisa Fitri
Published: August 2022

The competitive advantage of a company is supported by good management decision making, one of which is by having quality accounting information from the implementation of quality Accounting Information System (AIS). In this study, the effectiveness of Information Technology (IT) governance, knowledge management processes and information system control are factors that give an impact on the quality of AIS in generating accounting information. The purpose of this study is to analyze the positive impact of the effectiveness of Information Technology governance on the quality of AIS, the positive impact of the knowledge management process on the quality of AIS, the positive impact of information system control on the quality of information systems as well as the positive impact of the quality of AIS on the QAI. To measure all the variables, the researcher conducted an empirical test on 100 stated-owned enterprises (SOEs) in Indonesia with a questionnaire return rate of 345 respondents. The results of the study indicate that the effectiveness of Information Technology governance, knowledge management processes as well as information system control have a direct positive impact on the quality of information system, where the information system control has a strong impact on the quality of information systems. Moreover, the quality of AIS has a positive and strong impact on the Quality of Accounting Information (QAI).
Social responsibility model to empower community for higher education institution
Authors:   Manado State Polytechnic, Rumambi Hedy Desiree , Ohoitimur Johanis ,   Higher Institute of Philosophy Seminari Pineleng, Kaparang Revleen Mariana ,   Manado State Polytechnic, Lintong Jerry Sonny ,   Manado State Polytechnic, Tangon Joseph Nugraha ,   Manado State Polytechnic
Published: August 2022

This study aims to build a social responsibility model for higher education institutions (HEI) from human social nature. This study uses a qualitative research design. Data collection was carried out through in-depth interviews with several HEI management and literature studies related to the basis and limitations of the model. The data are analyzed, interpreted, elaborated, and the HEI social responsibility model is built. This model uses the perspective of human social nature. This model represents the essence of HEI’s social responsibility and provides a basic transformation in HEI management in terms of sustainability, transparency, and accountability. HEI’s social responsibility is concreted in teaching, research, and community service activities. By carrying out its social responsibilities, the institution will gain legitimacy from the community. Its existence will be well received to build synergy between the institution and the community, both the government and the local community. This has an impact on improving the image of HEI.
Endoscopic Debridement of Post-Radiation Nasopharyngeal Necrosis: The Effects of Resurfacing With a Vascularized Flap
Authors: Song Bokhyun , Kim Hyo Yeol , Jung ·Yong Gi , Baek Chung-Hwan , Chung Man Ki , Hong Sang Duk
Published: August 2022

Objectives. Post-radiation nasopharyngeal necrosis (PRNN) is a serious complication that severely impacts the quality of life and survival of nasopharyngeal carcinoma patients. Endoscopic debridement is considered the first-line treatment for PRNN. This study aimed to analyze clinical outcomes, focusing on the mucosal resurfacing status and the effectiveness of salvage operations.Methods. Twenty-seven patients who underwent endoscopic debridement were retrospectively analyzed. The patients were divided into two groups according to the initial surgical modality: debridement with a nasoseptal flap (NSF; n=21) and debridement only (no NSF; n=6). Clinical features, postoperative mucosal status, internal carotid artery (ICA) rupture, survival, and final mucosal status were evaluated. The NSF group was categorized according to flap viability to analyze risk factors for flap failure.Results. Regardless of the initial modality, most patients experienced symptom improvement (96.0% for headache and 100% for foul odor); however, complete cranial nerve palsy did not improve in any patients. In the NSF group, complete healing was observed in 66.7%, while all patients in the no-NSF group underwent salvage surgery because none maintained complete healing. In the NSF group, 19.0% of patients required salvage surgery. After the last operation, favorable symptom improvement was noted (100% for headache and 90.0% for foul odor), and 77.8% had completely healed mucosa, whereas only 14.8% and 7.4% had partial healing and persistent necrotic mucosal status. The necrotic or uncovered NSF subgroup showed statistically non-significant tendencies for old age, advanced necrosis stage, advanced T stage, ICA involvement, high frequency and dose of radiation therapy, diabetes mellitus, and underlying comorbidities. Two ICA ruptures and three deaths occurred.Conclusion. Resurfacing the nasopharynx with NSF after endoscopic debridement showed better outcomes than debridement only for PRNN treatment. Despite initial NSF failure, additional resurfacing reconstructive surgery offers advantages in symptom mitigation, quality of life, and survival.
Cine MRI Is Useful for the Diagnosis of Intradural Arachnoid Cyst with Spinal Arachnoid Web
Authors: Kawaguchi Hiroshi , Ono Koichiro , Takabayashi Naoya , Ito Toshihiko , Harada Kazuhiro , Sudo Yoshihiro , Kim Yong , Nakajima Takao , Miyamoto Masabumi , Majima Tokifumi
Published: August 2022

Case:

A 28-year-old woman developed gait disturbance due to lower limb weakness 3 years before presentation. Conventional magnetic resonance imaging (MRI) findings were inconclusive; therefore, we performed cine MRI, which confirmed the presence of a pulsatile cyst on the posterior thoracic spinal cord. The cyst compressed the spinal cord, and its pulsations synchronized with the patient's heartbeats. We resected the intradural arachnoid cyst and thickened arachnoid membrane. The gait disturbance improved after surgery.

Conclusions:

Cine MRI can be used to identify a pulsating arachnoid cyst that cannot be visualized with a conventional MRI. Cine MRI is useful in patients with unexplained spinal symptoms.
Development of Interactive Teaching Materials Based on Multiple Intelligences and Character
Authors: Rozhana Kardiana Metha
Published: August 2022

The purpose of this research is to produce interactive teaching materials for Multiple Intelligences and character values in the basic concepts of Civics Elementary School which are interesting and valid (both in terms of implementation, effectiveness, and usefulness). This study uses research and development methods (Research and Development). The sample of this study was 44 students of the PGSD Study Program at Tribhuwana Tunggadewi University batch 2019/2020. Based on the results of the trial, the results obtained successively with a score of 93.2% for product validity, 89% for product implementation, 92% for product usefulness, 90% for effectiveness, and 90% for product attractiveness. From these results it can be concluded that these teaching materials can improve the cognitive abilities and attitudes of students in the Primary School Teacher Education Study Program
Liver microbiota in healthy rats: the hidden inhabitants of hepatocytes
Authors: Sun Xiao Wei , Zhang Hua , Xin Peng Fei , Gao Xue , Li Hong Rui , Zhou Cai Yun , Gao Wen Min , Kou Xuan Xuan , Zhang Jian Gang
Published: August 2022

Abstract The tumor and tissue microbiomes of human beings have recently been investigated. Gut permeability was known as a possible resource for the positive detection of tissue bacteria. Herein, we report that bacteria were detected in high abundance in the hepatocyte nucleus of healthy rats, and that they were shared with gut microbiota to an extent. We assessed male Sprague Dawley (SD) rats for the 16S ribosomal ribonucleic acid (rRNA) gene. After rats were sacrificed by blood drainage from the portal vein, we extracted total deoxyribonucleic acid (DNA) from their ileal and colonic contents and liver tissues. The V3–V4 region of the 16S rRNA gene was amplified by polymerase chain reaction (PCR) and sequenced using an Illumina HiSeq 2500 platform. Sequences were assigned taxonomically by the SILVA database. We also detected bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA) in situ using immunofluorescence (IF) and western blotting and the 16S rRNA gene using fluorescent in situ hybridization (FISH). In the livers of six rats, we detected 54,867.50 ± 6450.03 effective tags of the 16S rRNA gene and clustered them into 1003 kinds of operational taxonomic units (OTUs; 805.67 ± 70.14, 729–893). Individuals showed conservation of bacterial richness, abundance, and evenness. LPS and the 16S rRNA gene were detected in the nuclei of hepatocytes. The main function composition of genomes of the annotated bacteria was correlated with metabolism (79.92 ± 0.24%). Gram negativity was about 1.6 times higher than gram positivity, and the aerobic and anaerobic phenotypes were nearly the same. Liver microbiota also showed high expression of mobile elements, biofilm formation, and stress tolerance, as well as potentially pathogenic phenotypes. Chemoheterotrophy, fermentation, and aerobic chemoheterotrophy were the main heterotrophic functions. Liver bacteria were shared with both the small and large intestines but showed significantly higher richness, evenness, and the β-diversity results showed that the liver microbiota exhibited significantly higher similarity than the small and large intestines (P < 0.05). The liver microbiota were hidden intracellular inhabitants in healthy rat livers and were shared with the gut microbiota.
The generalizations of fuzzy monoids and vague monoids
Authors: Li Wei , Wang Haohao , Liu Yuanhao , Yang Bin
Published: August 2022

In this paper, we present the fuzzy monoids and vague monoids by using aggregation operators. The unit interval with a t-norm or a t-conorm is a special monoid, so we mainly talk about fuzzy subsets of monoids. Firstly, the classification of fuzzy sets based on some special aggregation operators is discussed. At the same time, we give two basic propositions about submonoids of t-norm and t-conorm. The fuzzification by uninorm and nullnorm are denoted and some properties can be drawn. Next, we briefly present fuzzy subsets on lattice. Finally, the vague monoids on aggregation operators are redefined and further consider the special cases of uninorms and nullnorms.
Carotid plaque in STEMI: evidence of a missed opportunity to reclassify risk
Authors: Costa Diego , Croissant Yanina , González Carlos L , Perea Candelaria , Córsico Luciana , Acosta Florencia , Muzzio Maximiliano , Coronel Roberto
Published: August 2022

Aims: The presence of carotid plaque has been associated with an increased risk for adverse cardiovascular events. It is an early manifestation of subclinical atherosclerosis and can be assessed with a low-cost and widely available study such as carotid ultrasound. It has a class IIa recommendation in current guidelines to reclassify intermediate-risk patients, but there is a paucity of information about the prevalence of carotid disease in patients with acute coronary syndromes.Methods: Observational study in patients admitted for ST-elevation myocardial infarction (STEMI) in a tertiary care center, performing a carotid ultrasound before hospital discharge. Basal characteristics were obtained from electronic medical records. Differential characteristics according to the presence of carotid plaque were analyzed, and the atherosclerotic burden was assessed by the number of diseased vessels. Results: We included 191 patients with STEMI, and 57 (29.8%) had carotid plaque by ultrasound. The only significant difference between patients with or without carotid plaque was their age (54.36 ± 9.93 years versus 61.12 ± 11.48 years, p < 0.001). Patients with subclinical atherosclerotic disease were older, but other risk markers were similar, as was the use of aspirin and statins. The prevalence of carotid disease increased with the number of diseased vessels, indicating a relationship with atherosclerotic burden.Conclusion: The prevalence of carotid plaque detectable by ultrasound is approximately 30% in patients with STEMI. With a traditional risk evaluation, their baseline cardiovascular risk would have been assessed as mild or moderate, and few were treated with aspirin or statins. With a timely carotid ultrasound, they could have been reclassified as high-risk and treated accordingly. Only age was associated with the presence of carotid plaque, highlighting the importance of carotid ultrasound screening in patients greater than 55 years old.
Demography alone explains the polymorphic profiles on highly diverged loci between cultivated and wild rice
Authors: Xiang-Yu Jinggong , Gu Zhili , Li Haipeng , Lu Bao-Rong
Published: August 2022

The confounding effects of demography have hampered the efforts on mapping the causal genes of artificial selection during the domestication of animals and plants. It is challenging to distinguish selection from demography, especially for those derived populations subject to the effect of bottleneck. In this study, to examine whether highly diverged loci were subject to artificial selection during domestication, we developed a new statistical test and genotyped 45 InDel (insertion/deletion) loci in two subspecies of Asian cultivated rice (Oryza sativa ssp. japonica and Oryza sativa ssp. indica) and their wild progenitor (O. rufipogon / O. nivara). Among them, 17 loci are highly diverged (FST > 0.4) between rice cultivars and their ancestor. We performed coalescent-based simulations on neutral demographic scenarios and found that neutral demography alone could explain the polymorphic profiles on those highly diverged loci between cultivated and wild rice. Therefore, more signatures of selection should be considered when detecting artificial selection in rice.
To study the impact of screen time on IT Job professionals in India
Authors: N Rajesh Kumar , Jain Shreya , Bhargava Lakshita
Published: August 2022

This study aims to understand about the effects of screen time on the eyes, musculoskeletal problems, and efficiency at work in IT professionals. Problems faced by the people, along with the measures taken by them to solve those problems. A questionnaire was designed and distributed among IT professionals. Respondents discussed the various problems faced by them in terms of their eyes, musculoskeletal problems, and efficiency at work. Furthermore, respondents were asked if they and their organisations were taking any measures to deal with the problems due to the excessive effects of screen time. Insights were also drawn on how they can improve the current working system to deal with the effects of screen time. These insights were represented in the form of a word chart. In conclusion, a major percentage of the population is facing screen-related problems, but many people are not taking any measures to deal with them. Organizations and employees alike are advised to take these problems seriously and start putting their solutions into action as soon as possible.
Correlation of Serum IL-1β, IL-6, and hsCRP levels with Infarct Core and Ischemic Penumbra Volume in Acute Ischemic Stroke
Authors: Jianbo Zhou , Lin Li , Xiyang Ji , Xiaojie Zhang , Changfei Dai , Sa Wang , Mijuan Zhang , Dong Wei , Lele Zhang , Guoxun Zhang , Xixi Yang , Ming Guo , Bin Wang , Fan Li , Cheng Ma , Na Zhang , Qun Zhang , Ping Chen
Published: August 2022

Background
During cerebral ischemia, inflammatory factors such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and IL-1β released from the ischemic core may trigger neuronal death in the ischemic penumbra, influencing infarct volume. This study aimed to understand the relationship between serum IL-1β, IL-6, and high-sensitivity C-reactive protein (hs-CRP) levels with infarct core and ischemic penumbra volume in patients with acute ischemic stroke (AIS) and its influence on prognosis.
Methods
The serum levels of IL-1β, IL-6, and hs-CRP were measured in 65 patients within 24h of AIS onset. The infarcts of the patients were imaged with magnetic resonance imaging and magnetic resonance angiography. Alberta Stroke Program Early Computed Tomography Score (ASPECTS) and core volume on computed tomography perfusion or perfusion-weighted imaging were used to calculate infarct volume and ischemic penumbra volume. The Tan collateral score was calculated with Neusoft Brain Clinical Assistant Ration Evaluate (NeuBrainCARE).
Results
We found a significant correlation between infarct core volume and serum hs-CRP levels (P < 0.05) and between penumbra volume and IL-6 levels (P < 0.05). Serum IL-6 and hs-CRP levels were positively correlated with NIHSS scores at admission, discharge, and 3 months after discharge. IL-1β levels, Tan collateral score, and ASPECTS showed no correlation with the infarct core volume.
Conclusion
A significant correlation between hs-CRP and IL-6 levels and infarct and ischemic penumbra volume, respectively, and with NIHSS score shows that these two factors might prove helpful in predicting the extent of neurological damage in AIS patients after 3 months of onset, opening new avenues for treatment.
The Role of Fintech Firms' Sustainability at the time of the COVID-19 Period
Authors: Toumi Amina , najaf Khakan , Dhiaf Mohamed M. , Li Ng Shir , Kanagasabapathy Shenba
Published: August 2022

This study aims to understand the moderating role of envirnmental disclosures on the market performance of Fintech firms during the pandemic period. We gather 48 Fintech and 140 non-Fintech data from the sample period from 2011 until 2022. We use ordinary least squares and correlation as methodology. Our findings are two-fold: first, our study reveals that Fintech firms have depicted more environmental performance than non-Fintech firms during the pandemic period. Second, our studies show that sustainability performance is vital for market performance and contributes almost 10% to market performance of fintech firms during COVID-19 period. These findings are essential for the shareholders, policymakers and government. This study contributes to a better understanding of the sensitivity of shareholders towards sustainability disclosures.