bluuebunny/crossref_metadata_2025 huggingface dataset:
Honeybee drones make short trips to potentially survey the weather conditions
Authors: Wu Vivian
Published: September 2022

During the mating season, honeybee (Hymenoptera: Apidae) drones make mating fights to congregation areas where they face fierce competition to mate with a queen. Drones have developed distinct anatomical and functional features to optimize their chances of success. The flight activities of western honeybee (Apis mellifera) drones and foragers were monitored using radio frequency identification (RFID) to investigate whether drones have also developed distinct flight behaviors. Drone flight durations showed a bimodal distribution, dividing the flights into short trips and long trips, while forager flight durations showed a right-skewed unimodal distribution. Interestingly, the short trips of the drones occurred prior to the long trips on a daily basis. The first trips the drones made each day were primarily the short trips, and the distribution significantly shifted to the long trips as the drones made additional trips. In contrast, the forager trips showed no such shift in distribution. In addition, drones made short trips, but no long mating trips on days where there was a significant drop in temperature and increase in clouds compared with the previous day. These findings suggest that drones may have developed a unique flight behavior, making initial short trips to survey the weather conditions before flying out to the congregation area to pursue a successful mating.
Tubulovillous adenoma with high-grade dysplasia of the vulva harboring high tumor mutational burden and cancer-associated mutations: a case report
Authors: Sato Hanako , Murakami Kosuke , Otani Tomoyuki , Matsumura Noriomi
Published: September 2022

Background
Vulvar cancer is a rare disease, accounting for approximately 5% of gynecological malignancies. Primary adenocarcinoma of intestinal-type of the vulva or its precancerous lesion is extremely rare, and details regarding its origin, evolution and related genetic mutations are unknown. Treatment options for this cancer have not been defined.
Case presentation
A 63-year-old Japanese woman came to the hospital because she was aware of a vulvar mass. There was a 1 cm mass on the dorsal side of the vulva, just outside the remains of the hymen. Biopsy revealed suspected adenocarcinoma, and wide local excision was performed. From histopathology and immunohistochemistry, the specimen was diagnosed as tubulovillous adenoma with high-grade dysplasia of the vulva. No other primary lesions were found, and the vulva was considered the primary site. A gene panel test (FoundationOneCDx assay) showed a high tumor mutational burden and mutations in TP53, KEL, RB1, RNF43, PTEN, GNAS, and PIK3CA.
Conclusions
The current case of tubulovillous adenoma with high-grade dysplasia of the vulva had a variety of cancer-associated mutations, despite being a precancerous lesion. In cases of intestinal-type neoplasms of the vulva, it may be helpful to check tumor mutational burden and gene mutations for treatment selection.
Effects of soy protein isolate on the physicochemical properties of Fresh extruded rice- shaped kernels
Authors: Li Lu , Li Dandan , Li Xuejin , Wang Xiaodong , Li Xihong , Li Jixin , Jiang Yuqian , Jiang Yunbin
Published: September 2022

Gluten-free foods are often enhanced by the addition of proteins. Among these, plant-based proteins are often used as a good source of protein due to their easy absorption in the body and low environmental impact. In this work, Soy protein isolate (SPI) was used in an extruded food product to investigate the effect of SPI on the physicochemical properties of Fresh extruded rice-shaped kernels (FER). We used rheological techniques and thermal analysis to determine the suitability of the extrusion process and the loss of heating mass. The microstructure, textural properties, sensory evaluation and rice taste analyser scores of FER were determined. A new gluten-free food product was produced and its quality was improved by the addition of SPI. When the content of SPI was 3%, the microstructure and texture properties showed that the FER had medium hardness, good elasticity and cohesion, which was better than paddy rice in food quality analysis. During the extrusion process, SPI could not only be used as a structural aid to improve the rheological properties, thermogravimetric characteristics, microstructure and texture properties of FER, but also be used as a dietary supplement to improve the sensory quality of FER.
Association between eating behaviors with anthropometric indices and perceived stress in working women
Authors: Moradi Maryam , Abiri Behnaz , Rampisheh Zahra , Sarbakhsh Parvin , Tayefi Batool , Vafa Mohammadreza
Published: September 2022

Background: In recent decades, the significant increase in the prevalence of obesity, both in developing and developed countries, suggests that obesity is a complex health problem. Environmental factors such as lack of physical activity, excessive TV watching and sedentary lifestyle, consumption of high-calorie foods, and side effects of different drugs, can cause overweight and obesity. Obesity is associated with severe health problems such as diabetes, hypertension, hyperlipidemia, asthma, arthritis, and even reduced life expectancy. Obesity also has a profound effect on people's mental health.
Methods: After ethics committee approval from the Iran University of Medical Sciences (IR.IUMS.FMD.REC.1399.457), 395 healthy women between 20 to 50 years old entered the study. Questionnaires related to general information and assessment of individuals' status in terms of eating behaviors were completed on women from 20 to 50 years old who worked at the Iran University of Medical Sciences. Anthropometric variables including height, weight, body fat percentage, waist circumference, and hip circumference were measured and body mass index (BMI) and waist to hip ratio (WHR) were calculated. Then, a questionnaire related to perceived stress was completed by each participant. The 24-hour food recall questionnaire and the physical activity questionnaire were also conducted.
Results: In contrast to other studies, anthropometric indices (weight, height, BMI, waist circumference, and hip circumference) were reported higher in people who ate breakfast than in those who did not. There is no significant relationship between eating behaviors (speed rate, eating breakfast or not eating breakfast, and eating with or without a screen) and perceived stress levels. Anthropometric indices increase with increasing food intake and decreasing physical activity, while there is no relationship between dietary intake and physical activity with perceived stress levels.
Conclusion: Dietary behaviors and physical activity affect anthropometric indices, while, perceived stress levels do not affect dietary behaviors or anthropometric indices.
Association of major dietary patterns with the risk of obesity and metabolic syndrome in adults of Hoveizeh city
Authors: Ziba Bahar , Hosseini Seyed Ahmad , Cheraghian Bahman , Mansoori PhD Anahita
Published: September 2022

Introduction: Obesity is a multifactorial metabolic disorder, the development and progression of which can be caused by genetic, physiological, metabolic, socioeconomic and lifestyle factors (especially physical activity and diet). Therefore, considering the high prevalence of obesity and its complications, and taking into account that dietary patterns are different in different populations and geographical locations, the present study aims to identify and investigate the relationship between dietary patterns and Obesity diseases was conducted in the adult population of Hovizeh city. Method: 5821 participants (2076 obese group and 3745 not obese group) from Hoveizeh cohort study for this case control study were chosen. Data related to dietary, demographic, anthropometric and physical activity information were previously obtained through a questionnaire. dietary patterns were identified using factor analysis. Then, logistic regression method was used to determine the relationship between major food patterns and obesity. results: In this study, four major food patterns were identified, including 1) vegetable and high-protein food pattern, 2) traditional, 3) sweets and snacks, and 4) good oils. Following these patterns had no significant relationship with obesity and anthropometric indicators Conclusion: There was no association between identified dietary patterns and obesity.
The Outcome of Nationwide Community Outreach Service for Child and Adolescent with Mental Disabilities and Psychiatric Disorders in Taiwan: A 6-year Follow-up Study
Authors: Hsieh Wen-Yang , Hsu Chao-Wei , Li Wen-Chi , Tsai Ching-Hong , Ou Tian-Sin , Chang Ching-Wen , Chen Cheng-Chung
Published: September 2022

Objective
To improve the quality of health care, the Ministry of Health and Welfare of Taiwan start to launch a project in June 2015, providing community outreach services and outpatient psychiatric treatment to schools, institutions for child and adolescent patients with mental disabilities. The main purpose of this study was to analyze the development of the project and intended to promote medical service quality for child and adolescent patients.
Methods
Service team members from eight medical centers and psychiatric hospitals in Taiwan, providing both outreach community services and outpatient psychiatric treatment. We collected the personal information and assessment scale scores of all patients from January 2016 to December 2021 (N = 432).
Results
The findings revealed significant improvement in the scores of C-GAS, PSP, CGI-S, and CGI-I (p < 0.001). The scores of the self-reported assessment scale ASEBA also showed significant improvement for internalizing problems, externalizing problems and total problems (p < 0.001). Most of the disabled children and adolescents have benefited greatly from this project, including presenting less disruptive behavior, fewer hospital readmissions, and more improved adaptation.
Discussion
This 6-year community-based follow-up treatment shows that the majority of disabled patients continue experiencing an improved condition after intervention.
Prostaglandin E2 receptor EP1 expression in vulvar cancer
Authors: Buchholz Anna , Vattai Aurelia , Fürst Sophie , Vilsmaier Theresa , Zehni Alaleh Zati , Steger Alexander , Kuhn Christina , Schmoeckel Elisa , Dannecker Christian , Mahner Sven , Jeschke Udo , Heidegger Helene H.
Published: September 2022

Purpose
In recent years incidence of vulvar cancer has been on the rise, whereas therapeutic options are still restricted. Therefor new prognosticators and therapeutic targets are essential. Chronic inflammation plays an important role in carcinogenesis and COX-2, its product prostaglandin E2 and its receptors EP1–4 are known to be important mediators in cancer initiation and progression.
Methods
EP1 expression in vulvar cancer specimens (n = 129) was investigated via immunohistochemistry and evaluated using the well-established immunoreactive score (IRS). Subsequently, the values were correlated with clinicopathological parameters.
Results
Our analysis did not reveal EP1 expression as a negative prognostic factor in overall and disease-free survival. However, in the subgroup of patients with lymph node metastasis, overall survival was significantly shorter in tumors with high EP1 expression. Moreover, EP1 expression correlated positively with good differentiation of the tumor, but not with p16 status or COX-2 expression.
Conclusions
This study shed first light on EP1 expression in vulvar carcinoma. EP1 expression correlated significantly with the grading of the tumor, suggesting that it influences cell differentiation. Further research on EP1 signaling may lead to a deeper understanding of the molecular mechanisms of carcinogenesis.
Selection of Preferable Eco-Tourism Destinations using Analytical Hierarchy Process in Purulia District, West Bengal (India)
Authors: DOLUI SANU , chakraborty sayani
Published: September 2022

Eco-tourism is a form of nature based ecologically sustainable tourism, getting popularized in recent years among tourists due to the adverse impact of conventional tourism. The conventional way of tourism severely impacted the environment, loss of habitat and destruction of nature and natural landscape, Pressurizing local resources, and the Loss of cultural uniqueness of the local community. Purulia district in West Bengal (India), with its diversified picturesque landscape such as lush green Forest, mesmerizing riverscape, lakes, waterfall, hills, and uniqueness in the local community's culture gives ample potentiality of eco-tourism development. The aim of this paper to Explore potentiality of Ecotourism in Purulia district, West Bengal, India using analytical hierarchy process (AHP) and geographical information system (GIS). Initially ecotourism inventory dataset was developed based on following criteria: Elevation, Slope, Proximity River area, Distance from Road, Distance from Settlement patches, Distance from Ecological sites, Distance from railway Track, Distance from existing Tourism sites using ARC-GIS 10.6.1 software. Later, the suitability map of eco-tourism development has been developed by applying Weighted Linear Combination (WLC) with combination of the criteria with their respective weights and categorized into five suitability classes as Highly Suitable (S1), Moderately Suitable (S2), suitable (S3) less Suitable (S4), and unsuitable (S5). Finally, After the identification of suitable zones, six alternatives eco-tourism destinations are identified. This proposed method may be helpful for the for local stakeholders and public administration in identifying potential ecotourism destination and planning for sustainable eco-tourism development.
Assessment of radiographic and prognostic characteristics of programmed death-ligand 1 expression in high- grade gliomas
Authors: Ohno Makoto , Kitano Shigehisa , Satomi Kaishi , Yoshida Akihiko , Miyakita Yasuji , Takahashi Masamichi , Yanagisawa Shunsuke , Tamura Yukie , Ichimura Koichi , Narita Yoshitaka
Published: September 2022

Purpose
Gliomas are characterized by immunosuppressive features. Programmed death-ligand 1 (PD-L1) is overexpressed and plays an important role in the immunosuppressive tumor microenvironments of gliomas. However, the radiographical and prognostic significance of PD-L1 expression remain unclear.
Methods
Using tissue microarrays, we evaluated PD-L1 expression and the presence of tumor-infiltrating CD4 + and CD8 + T cells and CD204 + macrophages using immunohistochemical analysis. Contrast enhancement area and fluid-attenuated inversion recovery (FLAIR) hyperintensity area were evaluated by two-dimensional analysis. Kaplan–Meier analysis was performed to evaluate the overall survival time in 44 patients with isocitrate dehydrogenase (IDH)-wildtype glioblastoma.
Results
We evaluated 71 patients with newly diagnosed high-grade gliomas who were treated between October 1998 and April 2012. PD-L1 expression was observed in 15 patients (21.1%). A significant association of PD-L1 expression with the CD4 + and CD8 + T cell densities, but not with CD204 + macrophage density, was observed (p = 0.025, p = 0.0098, and p = 0.19, respectively). The FLAIR-to-enhancement ratio was significantly higher in PD-L1 + tumors than in PD-L1- tumors (p = 0.0037). PD-L1 expression did not show a significant association with the median survival time (PD-L1 + vs. PD-L1-: 19.2 vs. 14.9 months; p = 0.39).
Conclusion
PD-L1 expression was associated with CD4 + and CD8 + T cell infiltration, indicating a significant interplay between PD-L1 and immune cells. The positive correlation of PD-L1 expression with an increased FLAIR-to-enhancement ratio suggested that radiographical characteristics could reflect the immunological status. Our results did not support the prognostic impact of PD-L1 in patients with IDH-wildtype glioblastomas.
From Digital to Quantum Epidemiology: The Quantum Data Lake concept for Big Data related to viral infectious diseases
Authors: Kolesnichenko Olga , Nakonechniy Igor
Published: September 2022

The study is dedicated to the development of quantum epidemiology which is the expected next stage in epidemiology transformation as new quantum technologies have emerged. At the present time, epidemiology is entering the digital era and undergoes a paradigm shift from data-driven to value-driven strategy. The epidemiology data are characterized by uncertainty, multidimensionality, and disconnection, which drive to prefer the quantum approach for data exposition, creation of value, and modeling. The Quantum Data Lake concept is proposed. The data about DNA viruses with symptoms and diseases are shown as example of epidemiology data complexity. The Quantum Data Lake concept consists of several layers and quantum tools, including PT-symmetry and non-Hermiticity as intuitive modeling tools. PT-symmetry breaking is able to detect the hidden shift in the information which is permanently updated in the Data Lake. The duality of PT-symmetry breaking can be compared with the estimation of the best and worst scenarios simultaneously. In contrast to the widely discussed advantages of quantum computing such as high-speed performance and very large parallel scale, the proposed approach emphasizes the fundamental uniqueness of quantum theory for modeling. The study highlights the necessity to investigate the native processes of viruses’ interaction with the human population by relying on quantum theory’s natural properties. Implementation of quantum logic and reliance on a quantum theory is the fundamental difference between the current digital epidemiology and future quantum epidemiology.
What has drugs use and other factors got to do with suicidal behaviour among in-school students in Bolivia? Analysis of a national survey
Authors: Appiah Francis , Dorgbetor Cyprian Issahaku , Aidoo Antoinette Ama , Boakye Kingsley , Ayerakwah Patience Ansomah
Published: September 2022

Background
About 23.5% and 13.2% of female and male students respectively ever attempted suicide in 2017 in Bolivia. The annual prevalence of drugs usage such as marijuana has increased in Bolivia. Studies have highlighted that substance abuse correlates with suicidal behaviours. The association between drug use and suicidal behaviour is less explored in Bolivia. This study aimed at investigating the association between drug use and suicidal behaviour among in-school students in Bolivia.
Methods
The study relied on a dataset obtained from the 2018 Bolivian Global School-Based Student Health Survey (BGSHS). The survey followed a two-stage cluster sampling procedure and in all, a total of 7,931 in-school students were interviewed yielding a response rate of 79%. However, this study was restricted to 4,684 in-school students who have complete data about variables of interest analysed in the study. Suicidal behaviour and drug use were the outcome variable and main explanatory variables, respectively. At 95% confidence interval, two models were built using logistic regression. Model I assessed the association between the outcome variable and the main explanatory variable and Model II controlled the influence of covariates on suicidal behaviour. The results for Model II were presented in adjusted Odds Ratio (aOR).
Results
Generally, 17% (weighted N = 813; CI = 0.16–0.18) of students indulged in suicidal behaviour. Inferentially, those who ever used drugs were over two-fold likelihood to indulge in suicidal behaviour compared with those who were not on drugs in the unadjusted model [OR = 2.59, CI = 2.08–3.21] and this persisted in the adjusted model [aOR = 1.52, CI = 1.07–2.17]. Females [aOR = 3.02, CI = 2.51–3.63], those whoever had difficulties sleeping [aOR = 2.23, CI = 1.70–2.89], ever used alcohol [aOR = 1.57, CI = 1.30–1.90] and whose parents go through their things [aOR = 1.48, CI = 1.24–1.76] had higher odds of suicidal behaviour. The likelihood of suicidal behaviour reduced among those whose parents understand their problem [aOR = 0.55, CI = 0.45–0.68] and know their free time [aOR = 0.62, CI = 0.50–0.78] or were not bullied [aOR = 0.57, CI = 0.47–0.68].
Conclusion
The study revealed that drugs use was associated with suicidal behaviour among in-school students in Bolivia. Other findings were that alcoholism, poor parental concern, bullying and having a history of physical attacks were associated with suicidal behaviour. The Government of Bolivia through its law enforcement agencies should strengthen their strategies targeted at controlling drug usage among in-school students. Parents should extend emotional support and care to in-school students so that their wards can properly cope and manage their emotional challenges appropriately.
Impact of gamma (γ) irradiation on morphology, biochemical and antioxidant activity of green gram (Vigna radiata (L.) R. Wilczek)
Authors: D Arulbalachandran
Published: September 2022

One of the key sources of genetic variability that is ultimately used in the plant development program is mutations. In order to improve crops, mutagens are used, and mutants have been obtained from induced mutations. Gamma irradiation is one of the mutagens that helps to quantify the frequency and patterns of alterations in particular plants. In this present 26 study, the gamma irradiation effect was investigated by germination study and physiological characteristics of green gram. Seeds were exposed to a gamma source (CO60) at doses ranging from 100, 200, 300, 400, 500, 600, 700, and 800, with a non-irradiated sample as a control. Our results show that the germination percentages as well as morphological parameters of seedlings (root length, shoot length, fresh weight, and dry weight) decreased with increasing irradiation doses. These findings were confirmed by ESR spectroscopy with the g-factor at 2.000 ± 0.005. The photosynthetic pigments such as chlorophyll a and b were decreased in irradiated seedlings compared to control, where carotenoid content was increased. Biochemical content such as protein, amino acid, reducing sugar, starch and proline content was increased with increasing doses and it was concerned with various stretching bands analyzed by FTIR analysis. MDA content was increased with increasing doses by the production of free radicals. Antioxidant enzymes such as catalase and peroxidase were increased in irradiated seedlings, which act as free radical scavengers. These results suggested that there had been up to 600 Gy significant changes in morphology, photosynthetic pigment, biochemistry, and antioxidant analyses.
Crime Rate Prediction in Different Environment Using Hybrid Classifier
Authors: S. Santhosh , N. Sugitha
Published: September 2022

In the era of globalization, crime is a subject that is feared and dreaded by the public all around the world. Crime is an integral part of risks that we are facing it in every day. Nowadays, there have been many criminal cases reported by the mass media, such as theft, rape and sex offenses, robbery, murder and kidnappings. High crime rate makes people feel insecure, thus become one of the major problems in society. In the recent era of increasing volume crimes, crime prevention is now one of the most important global issues, along with the great concern of strengthening public security. The crime prediction method is to predict the crime rates that help police officer to prevent the crime rates in effective way. From that, we propose a new prediction method based on hybrid classifier. The proposed methodology consist of four stages namely, data collection, pre-processing, feature selection and prediction. Initially, the data are collected from internet. Then, in pre-processing stage, redundant and missing values are removed. After that, in feature selection process, important features are selected. Finally, the selected features are given to the hybrid classifier. Hybrid classifier is a combination of support vector machine (SVM) and artificial neural network (ANN). Finally, based on the score value, the crimes are predicted. The performance of proposed methodology is analysed in terms of different metrics. The proposed method implemented in JAVA. From the result, this method efficiently retrieves the features of the crime with a high accuracy of 94.028% compared to other existing methods.
Personalized medicine: current trends and prospects
Authors: Dolgopolov I. S. , Rykov M. Yu.
Published: September 2022

«Personalized» medicine is based on the belief that each person has unique molecular, physiological, environmental, and behavioral characteristics, and in case of disease, each patient should be treated taking into account these unique characteristics. This belief was to some extent confirmed by the use of the latest technologies, such as DNA sequencing, proteomics, imaging protocols and the use of wireless devices for health monitoring, which revealed large inter-individual differences. Literary sources (scientific articles) were searched, including those published in peer-reviewed journals indexed in PubMed, Wos, Scopus, and the Russian Science Citation Index. The review includes 49 articles on personalized medicine. It explores new technologies that make personalized medicine possible, new experiences, ways to test and apply individualized drugs, and potential treatments for people with fertility and infertility issues. It can be argued that the individualization of medical practice in certain cases is probably inevitable. Moreover, an individual approach to a patient becomes more efficient and cost-effective.
Overlap syndrome: association of gastroesophageal reflux disease with dyspepsia syndrome in schoolchildren
Authors: Polivanova T. V. , Vshivkov V. A.
Published: September 2022

The combination of gastroesophageal reflux disease with dyspepsia syndrome in a particular patient is designated as overlap syndrome, the problem of which is widely discussed.

Purpose. To study the regional characteristics of the association of gastroesophageal reflux disease with dyspepsia syndrome in Siberian schoolchildren with gastrointestinal complaints.

Materials and methods. Schoolchildren of  Siberia 7–17 years old were examined: in  Tyva (1535 children), Buryatia (790 children), and Evenkia (1369 children). Information about gastroenterological complaints was collected. By the method of random selection, children with gastroenterological complaints underwent esophagogastroduodenoscopy in Tyva, 283 children, in Buryatia, 110 children, and in Evenkia, 205 children. The studies were approved by the ethics committee and the consent of the patients and their parents was obtained.

Results. In Siberian schoolchildren, the prevalence of GERD and DS overlap syndrome was 4.7%. In Tyva, the overlap of gastroesophageal reflux disease with dyspepsia syndrome in  schoolchildren was found most often: 6.9%, which was significantly higher than in Buryatia (3.7%; p = 0.0016) and in Evenkia (2.8%; p = 0.0001). regional features have been established in the distribution of clinical variants of dyspepsia associated with gastroesophageal reflux disease in schoolchildren. So, in the children of Buryatia and Evenkia, the dominant association was gastroesophageal reflux disease with postprandial distress syndrome, in Tyva — with epigastric pain. Among endoscopically examined schoolchildren in the absence of erosive and ulcerative diseases, similar associative relationships between gastroesophageal reflux disease with dyspepsia syndrome and its clinical variants were determined.

Conclusion. Regional differences were established, both in the prevalence of overlap syndrome and the severity of the association of gastroesophageal reflux disease with variants of the clinical course of dyspepsia syndrome. It is not unlikely that overlapping disorders are united by a single leading pathomechanism in their formation.
E-WOM and consumers’ purchase intention: An empirical study on Facebook
Authors: Al-Haddad Shafig , Ahmad Sharabati Abdel-Aziz , Harb Lana , Husni Aarab , Abdelfattah Maisam
Published: September 2022

Nowadays, organizations use social media to promote their services and products. At the same time, they use different tools to convey their messages, such as Facebook. Therefore, this study aims to investigate the factors that affect the e-WOM on Jordanian consumers’ purchase intention over Facebook. The study uses the information acceptance model (IAM) to examine the impact of information credibility, information quality, information adoption, and information usefulness over Facebook on Jordanian consumers’ purchase intention. The study uses cross-sectional quantitative research and is conducted online. The questionnaire was distributed through Facebook and WhatsApp, and the people who used only Facebook were allowed to complete the survey. Out of 327 filled questionnaires, only 304 were valid for further analysis. Collected data were coded in SPSS, and after confirming the validity and reliability of the tool, the correlation between variables was checked. In addition, multiple regressions were used to test the hypotheses. Multiple regression results show that the E-WOM can explain 49.2% of the total variation in the consumers’ purchase intention, where R2 = 0.492. Information adoption has the strongest effect on consumers’ purchase intention (β = 0.489), followed by information usefulness (β = 0.204). In contrast, information credibility and information quality do not have a significant effect on customers’ purchase intention (0.189 and 0.312, respectively). This study helps companies and businesses that have pages on Facebook to understand how consumers engage in the e-WOM on business pages and consider the consumers’ reviews, comments, or posts.
IN SILICO PREDICTION OF INHIBITORY POTENTIAL OF A PUNICALAGIN β-ANOMER AGAINST SARS-COV-2 MAIN PROTEASE (MPRO)
Authors: Monteiro Norberto , Monteiro Vitória , Lima Lorena , Karolline Anna , Machado Richele
Published: September 2022

The pandemic caused by the new coronavirus has resulted in a global health emergency and has prompted an urgent need for new treatment strategies. No target-specific drugs are currently available for SARS-CoV-2, but new drug candidates targeting the viral replication cycle are being explored. A prime target of drug-discovery efforts is the SARS-CoV-2 main protease (Mpro). In this work, we identified a potential inhibitor for SARS-CoV-2 main protease using in silico methodologies. Molecular docking and molecular dynamics studies were carried out to ascertain the inhibitory action of α and β anomers of Punicalagin from fruit peel of Punica granatum against the Mpro protease. The molecular dynamics results revealed that the β-anomeric configuration of punicalagin allowed access to more hydrogen bonds and hydrophobic interaction leading to higher selectivity and specificity of β-anomer than α-anomer. Therefore, the β-anomer of Punicalagin could act as potential inhibitor against the main protease of SARS-CoV-2 and may act as a potential drug candidate
CURRÍCULO MÍNIMO VERSUS DIRETRIZES NACIONAIS DE CURSO: CAMINHOS DIVERGENTES NA FORMAÇÃO DOS PROFISSIONAIS DA QUÍMICA
Authors: Machado Sérgio , Cortes Carlos , Almada Rafael
Published: September 2022

MINIMUM CURRICULUM VERSUS NATIONAL COURSE GUIDELINES: DIVERGENT PATHS IN THE TRAINING OF PROFESSIONALS IN CHEMISTRY. The professional practice of chemist is defined by Ordinary Resolution no 1,511 of 1975, edited by the Federal Council of Chemistry. This legislation is outdated and not in line with the National Curricular Guidelines for chemistry courses, approved by the National Council of Education in 2001. This situation has greatly hampered the training of future chemistry professional and the modernization of undergraduate courses and must be urgently corrected by those responsible for formulating the legislation that defines the chemistry courses. Thus, we understand that the time has come for the Federal Council of Chemistry, Scientific Societies and Universities to work together to solve this problem, modernizing the legislation that defines the attributions of the chemistry professionals and defining the necessary profile for their professional practice in the XXI century.
Convivencia escolar desde el marco de la psicología evolutiva y de la educación
Authors: Zych Izabela
Published: September 2022

La promoción de la convivencia escolar es una tarea imprescindible en las escuelas del siglo XXI, que, aparte de la enseñanza del contenido académico, están llamadas a preparar para la vida y prevenir la violencia. Aunque se reconozca la importancia de la convivencia escolar y se hayan implementado diversos programas para su promoción, todavía es necesario profundizar en el conocimiento de las bases psicológicas que fundamentan el quehacer de las escuelas en relación con la convivencia. Por ello, en el presente artículo se pretende delimitar el concepto de convivencia escolar y se propone un modelo de convivencia escolar basado en los conocimientos de la Psicología Evolutiva y de la Educación. Se trata de un modelo en el que la convivencia escolar se nutre de factores personales y contextuales para la prevención de la violencia y promoción de la ciudadanía y la paz. Con este propósito, se realiza una revisión de literatura científica sobre diversos componentes de la convivencia escolar y su desarrollo normativo en el alumnado, y una propuesta de su promoción a través de la educación. La convivencia se conceptualiza desde una perspectiva positiva a partir de la promoción de conductas prosociales.
Activación de Recursos durante la primera sesión de psicoterapia y su relación con el cambio terapéutico temprano
Authors: Salvo Rivera José Domingo , Krause Jacob Mariane , Uribe Pesqueira Lucas , Ramírez Claveriè Ivonne
Published: September 2022

Objetivo: determinar diferencias en el grado en que los terapeutas enfocan sus intervenciones en activar recursos de los consultantes durante la primera sesión en procesos de psicoterapia con y sin resultados terapéuticos tempranos (RT), y caracterizar dichas intervenciones. Método: se utilizó una muestra de 32 procesos de psicoterapia con pacientes ambulatorios, realizados en contextos de prestación rutinaria de servicios y conducidos por terapeutas de distintas orientaciones teóricas. Estos procesos se agruparon según la presencia o ausencia de RT, evaluada a partir de la diferencia de puntajes en el reporte de bienestar de los consultantes entre la primera y la cuarta sesión, a través del Cuestionario de Autoreporte de Resultados (Outcome Questionnaire -OQ-45.2.-). Y el grado en que la actividad de los terapeutas se enfocó en la Activación de Recursos (AR) se evaluó mediante el Wirkfaktoren-K (WIFA-K. Factores de Efectividad de Klaus Grawe) para jueces independientes. Posteriormente, se realizó una prueba t de varianzas desiguales de Welch, a partir de los promedios de puntajes de la AR en ambos grupos. Resultados: se encontraron diferencias significativas entre ambos grupos; específicamente, los terapeutas del grupo Con RT dedicaron tres veces más tiempo de la sesión a trabajar en la AR que los del grupo Sin RT. Adicionalmente, se ofrece evidencia detallada respecto de la variación del foco en la AR a lo largo de la sesión y la proporción en que distintos contenidos relacionados con la AR son abordados en ambos grupos.
Different Modalities Used in the Art of Managing Tracheobronchial Foreign Bodies
Authors: Hemead Hanan M. , Ramadan Abdelmaguid , Gaafar Alaa H. , Nossier Ayman , Abdelaziz Ahmed
Published: September 2022

Introduction:

Foreign body aspiration is a commonly encountered and challenging emergency. Foreign body aspiration causes significant morbidity and mortality in the paediatric population. In adults, it is usually encountered in patients with impaired consciousness and in young females using pins to secure their veils. We aimed to analyse the incidence, type and site of foreign body, radiological presentation, complications and different modalities used in managing tracheobronchial foreign bodies (FBs).

Methods:

A prospective single centre cross-sectional study between December 2010 and December 2011 in the Department of Cardiothoracic Surgery at the University of Alexandria, Egypt.

Results:

Seventy-eight patients were included. The age of the patients ranged between 1.3 and 32 years, with a mean of 13.37± 7.67 years. Inorganic FBs were the most common aspirated FBs (66 patients, 84.62%). FBs were more frequently located in the left versus the right bronchial tree (44.9% vs. 43.6%). Rigid bronchoscopic extraction of foreign bodies was the most common modality of extraction and was seen in 60 patients (76.9%), followed by thoracotomy and postural drainage in eight patients each (10.3%). Complications were observed in 12 patients (15.4%). Most of the patients who presented with pin aspiration were teenagers (> 10 – 20 years) and adults (> 20 years). At the same time, nut aspiration was common in children below 10 years.

Conclusion:

The location of FBs in the tracheobronchial tree depends on the patient's age and physical position at the time of aspiration. Rigid bronchoscopy offers better manipulations inside a secured airway and is the preferred method for foreign body removal. If failed, then surgical extraction should be done as soon as possible.
Sequía experimental en plántulas en un claro y en el sotobosque de un bosque de niebla, Veracruz, México
Authors: Manrique-Ascencio Avril , Williams-Linera Guadalupe , Badano Ernesto I.
Published: September 2022

Antecedentes y Objetivos: Se espera que las sequías inducidas por el cambio climático afecten al bosque de niebla. Como los rasgos funcionales son indicadores útiles del desempeño de especies vegetales, el objetivo de este trabajo fue determinar el efecto del ambiente lumínico y la sequía sobre área foliar (AF), área foliar específica (AFE), contenido de clorofila, grosor, dureza foliar, supervivencia y tasas de crecimiento relativo (TCR) de plántulas en sotobosque y claro.
Métodos: En un bosque de niebla en Veracruz, México, se usaron exclusiones de lluvia para simular sequía en sotobosque y claro. Se midieron AF, AFE, contenido de clorofila, grosor, dureza, supervivencia y TCR en Eugenia capuli (especie de sotobosque tolerante a la sombra), Liquidambar styraciflua (especie del dosel de tolerancia intermedia) y Trema micranthum (árbol pionero colonizador de claros) en sotobosque-control y -sequía, y claro-control y -sequía.
Resultados clave: El AF aumentó con sequía en E. capuli en claro y decreció para L. styraciflua en ambos ambientes lumínicos. El contenido de clorofila fue similar entre tratamientos de agua para E. capuli y L. styraciflua en sotobosque. El grosor y dureza foliares difirieron con sequía para E. capuli y L. styraciflua en claro. Los rasgos foliares de T. micranthum cambiaron solo en sotobosque. Eugenia capuli presentó la mayor y similar supervivencia entre tratamientos. Liquidambar styraciflua mostró una mayor supervivencia en claro-sequía, y T. micranthum en claro. Eugenia capuli tuvo la mayor TCR en sotobosque, mientras que T. micranthum en claro.
Conclusiones: Los rasgos funcionales de plántulas de E. capuli y L. styraciflua respondieron a sequía moderada más en claro que en sotobosque. Los resultados sugieren que los rasgos funcionales de las especies intermedia y tolerante a la sombra tienden a cambiar menos bajo una sequía moderada, que los del árbol pionero si se mantiene el ambiente lumínico forestal.
Feasibility and Acceptability of Music Imagery and Listening Interventions for Analgesia: Protocol for a Randomized Controlled Trial
Authors: Story Kristin M , Bravata Dawn M , Robb Sheri L , Wasmuth Sally , Slaven James E , Whitmire Leah , Barker Barry , Menen Tetla , Bair Matthew J
Published: September 2022

Background

Chronic pain and access to care are identified as critical needs of the Veterans Health Administration. Music imagery and music listening interventions have shown promise as effective nonpharmacological options for pain management. However, most studies have focused on acute pain, passive music experiences, and in-person delivery.

Objective

In this study, we aimed to examine the feasibility and acceptability of 2 music interventions delivered through telehealth for chronic musculoskeletal pain, trial design, and theoretical model before conducting a fully powered efficacy or comparative effectiveness trial.

Methods

FAMILIA (Feasibility and Acceptability of Music Imagery and Listening Interventions for Analgesia) is a 3-arm, parallel group, pilot trial. A total of 60 veterans will be randomized to one of the three conditions: music imagery, music listening, or usual care. Aim 1 is to test the feasibility and acceptability of a multicomponent, interactive music imagery intervention (8-weekly, individual sessions) and a single-component, minimally interactive music learning intervention (independent music listening). Feasibility metrics related to recruitment, retention, engagement, and completion of the treatment protocol and questionnaires will be assessed. Up to 20 qualitative interviews will be conducted to assess veteran experiences with both interventions, including perceived benefits, acceptability, barriers, and facilitators. Interview transcripts will be coded and analyzed for emergent themes. Aim 2 is to explore the effects of music imagery and music listening versus usual care on pain and associated patient-centered outcomes. These outcomes and potential mediators will be explored through changes from baseline to follow-up assessments at 1, 3, and 4 months. Descriptive statistics will be used to describe outcomes; this pilot study is not powered to detect differences in outcomes.

Results

Recruitment for FAMILIA began in March 2022, and as of July 2022, 16 participants have been enrolled. We anticipate that enrollment will be completed by May 2023. We expect that music imagery and music listening will prove acceptable to veterans and that feasibility benchmarks will be reached. We hypothesize that music imagery and music listening will be more effective than usual care on pain and related outcomes.

Conclusions

FAMILIA addresses four limitations in music intervention research for chronic pain: limited studies in veterans, evaluation of a multicomponent music intervention, methodological rigor, and internet-based delivery. Findings from FAMILIA will inform a fully powered trial to identify putative mechanisms and test efficacy.

Trial Registration

ClinicalTrials.gov NCT05426941; https://tinyurl.com/3jdhx28u

International Registered Report Identifier (IRRID)

DERR1-10.2196/38788
Development of Mobile-Based Personal Health Record Maternal and Child Using Glide App: Development and Usability Study (Preprint)
Authors: Ombong Deva Indri Saputri
Published: September 2022

BACKGROUND

The world calls for increased access and maternal and child health services. This is in line with the global targets contained in the 2030 Sustainable Development Goals (SDGs), namely to eliminate all forms of malnutrition in children under five, adolescent girls, pregnant and lactating mothers, and the elderly. One way is to increase access to personal health data so that patients know the importance of monitoring their health. Therefore, it is necessary to develop applications for personal health records of mothers and children to support the achievement of the SDGs targets by 2030.

OBJECTIVE

This paper aims to design and build a mobile-based application for personal health records for maternal and children.

METHODS

This design phase uses the waterfall method during the product evaluation. Requirement analysis based on the data collected with interviews, observations, and literature studies, then product evaluation using the System Usability Testing (SUS) method.

RESULTS

This design produces a Unified Modeling Language (UML) design consisting of use cases and activity diagrams, a user interface design, and a maternal and child personal health record application named SIKIA (Maternal and Child Health Application). This design also creates the final product evaluation result, which states that the SIKIA application can easily accept by the user (acceptable).

CONCLUSIONS

The design of the mobile-based mother and child personal health record application has been approved and is by user needs.
The feasibility of implementing remote measurement technologies in psychological treatment for depression: a mixed-methods study on engagement (Preprint)
Authors: de Angel Valeria , Adeleye Fadekemi , Zhang Yuezhou , Cummins Nicholas , Munir Sara , Lewis Serena , Laporta Puyal Estela , Matcham Faith , Sun Shaoxiong , Dobson Richard , Hotopf Matthew
Published: September 2022

BACKGROUND

Remote Measurement Technologies (RMTs) such as smartphones and wearables, can help improve treatment for depression by providing more objective, continuous, and ecologically valid insight into mood and behavior. Engagement with RMTs is varied and highly context-dependent, yet few studies have investigated their feasibility in the context of treatment.

OBJECTIVE

A mixed-methods design was used to evaluate engagement with active and passive data collection via RMT in people with depression undergoing psychotherapy. We evaluated the effects of treatment on two different types of engagement: study attrition (engagement with study protocol), and patterns of missing data (engagement with digital devices) which we termed data availability. Qualitative interviews were conducted to help interpret engagement differences.

METHODS

Sixty-six people undergoing psychological therapy for depression were followed up for 7 months. Active data in the form of weekly questionnaires, speech, and cognitive tasks were generated, and passive data were gathered from smartphone sensors and a Fitbit wearable device

RESULTS

Overall study retention was 60%. Higher-intensity treatment and higher baseline anxiety were associated with increased attrition, but depression severity was not. A trend towards significance was found for the association between longer treatments and increased attrition.

Data availability was higher for active data than passive data but declined at a sharper rate (90% to 30% drop in 7 months). Within passive data, wearable data availability fell from a maximum of 80% to 45% at 7 months but showed higher overall data availability compared to smartphone-based data, which remained stable at the 20-40% range throughout. Missing data was more prevalent in GPS location data, followed by Bluetooth, than accelerometry. For active data, speech and cognitive tasks had lower completion rates than clinical questionnaires. Participants in treatment provided less Fitbit data but higher active data during treatment than those on the waiting list.

CONCLUSIONS

Different data streams showed varied patterns of missing data despite being gathered from the same device. Longer and more complex treatments as well as clinical characteristics like higher baseline anxiety may reduce long-term engagement with RMTs, and different devices may show opposite patterns of missingness during treatment. This has implications for the scalability and uptake of RMTs in healthcare settings, as well as for the generalisability and accuracy of the data collected by these methods, feature construction, and the appropriateness of their use in the long-term.
La evolución del imaginario geopolítico de Brasil
Authors: Sequeira Miguéis Ana Luísa
Published: September 2022

The following article proposes a critical analysis on the constitution of the Brazilian geopolitical imagery, stretching from the time of Brazil’s independence to the beginning of the 21st century. More specifically, the text recognises the impact of the country’s colonial past on Brazil’s prevalent geopolitical thinking. That, along with the significance of certain geopolitical thinkers, theoretical approaches and specific socio-political contexts, would explain why factors such as the need to have a state-led plan that promotes integration in furtherance of progress, and Brazil’s hegemonic overreach at the regional and global levels, have been historically dominant in the Brazilian geopolitical vision. Similarly, it is argued that the concern to achieve an effective unification of the national territory, by means of carrying out projects to populate the Amazon, featured predominantly in the geopolitical strategies of Brazilian leaders. These strategies brought about effects visible within and beyond Brazil’s borders, the latter as regional integration initiatives.