bluuebunny/crossref_metadata_2025 huggingface dataset:
Supercritical CO2-Assisted Spray Drying of Strawberry-Like Gold-Coated Magnetite Nanocomposites in Chitosan Powders for Inhalation
Authors: Silva Marta , Silva Ana , Fernandez-Lodeiro Javier , Casimiro Teresa , Lodeiro Carlos , Aguiar-Ricardo Ana
Published: January 2017

Lung cancer is one of the leading causes of death worldwide. Therefore, it is of extreme importance to develop new systems that can deliver anticancer drugs into the site of action when initiating a treatment. Recently, the use of nanotechnology and particle engineering has enabled the development of new drug delivery platforms for pulmonary delivery. In this work, POXylated strawberry-like gold-coated magnetite nanocomposites and ibuprofen (IBP) were encapsulated into a chitosan matrix using Supercritical Assisted Spray Drying (SASD). The dry powder formulations showed adequate morphology and aerodynamic performances (fine particle fraction 48%–55% and aerodynamic diameter of 2.6–2.8 µm) for deep lung deposition through the pulmonary route. Moreover, the release kinetics of IBP was also investigated showing a faster release of the drug at pH 6.8, the pH of lung cancer. POXylated strawberry-like gold-coated magnetite nanocomposites proved to have suitable sizes for cellular internalization and their fluorescent capabilities enable their future use in in vitro cell based assays. As a proof-of-concept, the reported results show that these nano-in-micro formulations could be potential drug vehicles for pulmonary administration.
XPS Study on the Stability and Transformation of Hydrate and Carbonate Phases within MgO Systems
Authors: Rheinheimer Vanessa , Unluer Cise , Liu Jiawei , Ruan Shaoqin , Pan Jisheng , Monteiro Paulo
Published: January 2017

MgO cements have great potential for carbon sequestration as they have the ability to carbonate and gain strength over time. The hydration of reactive MgO occurs at a similar rate as ordinary Portland cement (PC) and forms brucite (Mg(OH)2, magnesium hydroxide), which reacts with CO2 to form a range of hydrated magnesium carbonates (HMCs). However, the formation of HMCs within the MgO–CO2–H2O system depends on many factors, such as the temperature and CO2 concentration, among others, which play an important role in determining the rate and degree of carbonation, the type and stability of the produced HMCs and the associated strength development. It is critical to understand the stability and transformation pathway of HMCs, which are assessed here through the use of X-ray photoelectron spectroscopy (XPS). The effects of the CO2 concentration (in air or 10% CO2), exposure to high temperatures (up to 300 °C) and curing period (one or seven days) are reported. Observed changes in the binding energy (BE) indicate the formation of different components and the transformation of the hydrated carbonates from one form to another, which will influence the final performance of the carbonated blends.
The Influence of Austenite Grain Size on the Mechanical Properties of Low-Alloy Steel with Boron
Authors: Białobrzeska Beata , Konat Łukasz , Jasiński Robert
Published: January 2017

This study forms part of the current research on modern steel groups with higher resistance to abrasive wear. In order to reduce the intensity of wear processes, and also to minimize their impact, the immediate priority seems to be a search for a correlation between the chemical composition and structure of these materials and their properties. In this paper, the correlation between prior austenite grain size, martensite packets and the mechanical properties were researched. The growth of austenite grains is an important factor in the analysis of the microstructure, as the grain size has an effect on the kinetics of phase transformation. The microstructure, however, is closely related to the mechanical properties of the material such as yield strength, tensile strength, elongation and impact strength, as well as morphology of occurred fracture. During the study, the mechanical properties were tested and a tendency to brittle fracture was analysed. The studies show big differences of the analysed parameters depending on the applied heat treatment, which should provide guidance to users to specific applications of this type of steel.
Effects of Austenitizing Conditions on the Microstructure of AISI M42 High-Speed Steel
Authors: Luo Yiwa , Guo Hanjie , Sun Xiaolin , Mao Mingtao , Guo Jing
Published: January 2017

The influences of austenitizing conditions on the microstructure of AISI M42 high-speed steel were investigated through thermodynamic calculation, microstructural analysis, and in-situ observation by a confocal scanning laser microscope (CSLM). Results show that the network morphology of carbides could not dissolve completely and distribute equably in the case of the austenitizing temperature is 1373 K. When the austenitizing temperature reaches 1473 K, the excessive increase in temperature leads to increase in carbide dissolution, higher dissolved alloying element contents, and unwanted grain growth. Thus, 1453 K is confirmed as the best austenitizing condition on temperature for the steel. In addition, variations on the microstructure and hardness of the steel are not obvious when holding time ranges from 15 to 30 min with the austenitizing temperature of 1453 K. However, when the holding time reaches 45 min, the average size of carbides tends to increase because of Ostwald ripening. Furthermore, the value of Ms and Mf decrease with the increase of cooling rate. Hence, high cooling rate can depress the martensitic transformation and increase the content of retained austenite. As a result, the hardness of the steel is the best (65.6 HRc) when the austenitizing temperature reaches 1453 K and is held for 30 min.
Synthetic Assembly of Mannose Moieties Using Polymer Chemistry and the Biological Evaluation of Its Interaction towards Concanavalin A
Authors: Diwan Deepti , Shinkai Kohei , Tetsuka Toshihiro , Cao Bin , Arai Hidenao , Koyama Tetsuo , Hatano Ken , Matsuoka Koji
Published: January 2017

Protein–carbohydrate interactions exhibit myriad intracellular recognition events, so understanding and investigating their specific interaction with high selectivity and strength are of crucial importance. In order to examine the effect of multivalent binding on the specificity of protein–carbohydrate interactions, we synthesized mannose glycosides as a novel type of glycosylated monomer and glycopolymers of polyacrylamide derivatives with α-mannose (α-Man) by radical polymerization and monitored their strength of interaction with concanavalin A (Con A) by surface plasmon resonance (SPR) detection. In a quantitative test using the Con A-immobilized sensor surface, the kinetic affinity for the synthesized polymers, 8a (KD = 3.3 × 10−6 M) and 8b (KD = 5.3 × 10−5 M), were concentration-dependent, showing strong, specific molecular recognition abilities with lectin. Our study showed the enhancement in recognition specificity for multivalent saccharides, which is often mediated by cell surface carbohydrate-binding proteins that exhibit weak affinity and broad specificity for the individual ligands.
Body Adiposity Index Performance in Estimating Body Fat Percentage in Colombian College Students: Findings from the FUPRECOL—Adults Study
Authors: Ramírez-Vélez Robinson , Correa-Bautista Jorge , González-Ruíz Katherine , Vivas Andrés , Triana-Reina Héctor , Martínez-Torres Javier , Prieto-Benavides Daniel , Carrillo Hugo , Ramos-Sepúlveda Jeison , Villa-González Emilio , García-Hermoso Antonio
Published: January 2017

Recently, a body adiposity index (BAI = (hip circumference)/((height)(1.5))−18) was developed and validated in adult populations. The aim of this study was to evaluate the performance of BAI in estimating percentage body fat (BF%) in a sample of Colombian collegiate young adults. The participants were comprised of 903 volunteers (52% females, mean age = 21.4 years ± 3.3). We used the Lin’s concordance correlation coefficient, linear regression, Bland–Altman’s agreement analysis, concordance correlation coefficient (ρc) and the coefficient of determination (R2) between BAI, and BF%; by bioelectrical impedance analysis (BIA)). The correlation between the two methods of estimating BF% was R2 = 0.384, p < 0.001. A paired-sample t-test showed a difference between the methods (BIA BF% = 16.2 ± 3.1, BAI BF% = 30.0 ± 5.4%; p < 0.001). For BIA, bias value was 6.0 ± 6.2 BF% (95% confidence interval (CI) = −6.0 to 18.2), indicating that the BAI method overestimated BF% relative to the reference method. Lin’s concordance correlation coefficient was poor (ρc = 0.014, 95% CI = −0.124 to 0.135; p = 0.414). In Colombian college students, there was poor agreement between BAI- and BIA-based estimates of BF%, and so BAI is not accurate in people with low or high body fat percentage levels.
25-Hydroxy-Vitamin D Concentration Is Not Affected by Severe or Non-Severe Pneumonia, or Inflammation, in Young Children
Authors: Haugen Johanne , Chandyo Ram , Ulak Manjeswori , Mathisen Maria , Basnet Sudha , Brokstad Karl , Valentiner-Branth Palle , Shrestha Prakash , Strand Tor
Published: January 2017

Poor vitamin D status has been associated with increased risk and severity of respiratory tract infections. Whether or not inflammation and infection affects 25-hydroxy vitamin D (25(OH)D) concentration is controversial and is important in the interpretation of observational studies using plasma-25(OH)D as a biomarker for status. Our objectives were to measure whether 25(OH)D concentration was altered by an episode of acute lower respiratory tract infection and whether markers of inflammation predicted the 25(OH)D concentration. Children aged 2–35 months with severe (n = 43) and non-severe (n = 387) community-acquired, WHO-defined pneumonia were included. 25(OH)D concentration and inflammatory markers (cytokines, chemokines, and growth factors) were measured in plasma during the acute phase and 14, 45, and 90 days later. Predictors for 25(OH)D concentrations were identified in multiple linear regression models. Mean 25(OH)D concentration during the acute phase and after recovery (14, 45, and 90 days) was 84.4 nmol/L ± 33.6, and 80.6 ± 35.4, respectively. None of the inflammatory markers predicted 25(OH)D concentration in the multiple regression models. Age was the most important predictor for 25(OH)D concentration, and there were no differences in 25(OH)D concentrations during illness and after 14, 45, and 90 days when adjusting for age. Infection and inflammation did not alter the 25(OH)D concentration in young children with acute lower respiratory tract infections.
Very Low-Protein Diet (VLPD) Reduces Metabolic Acidosis in Subjects with Chronic Kidney Disease: The “Nutritional Light Signal” of the Renal Acid Load
Authors: Di Iorio Biagio , Di Micco Lucia , Marzocco Stefania , De Simone Emanuele , De Blasio Antonietta , Sirico Maria , Nardone Luca ,   On behalf of UBI Study Group
Published: January 2017

Background: Metabolic acidosis is a common complication of chronic kidney disease; current guidelines recommend treatment with alkali if bicarbonate levels are lower than 22 mMol/L. In fact, recent studies have shown that an early administration of alkali reduces progression of CKD. The aim of the study is to evaluate the effect of fruit and vegetables to reduce the acid load in CKD. Methods: We conducted a case-control study in 146 patients who received sodium bicarbonate. Of these, 54 patients assumed very low-protein diet (VLPD) and 92 were controls (ratio 1:2). We calculated every three months the potential renal acid load (PRAL) and the net endogenous acid production (NEAP), inversely correlated with serum bicarbonate levels and representing the non-volatile acid load derived from nutrition. Un-paired T-test and Chi-square test were used to assess differences between study groups at baseline and study completion. Two-tailed probability values ≤0.05 were considered statistically significant. Results: At baseline, there were no statistical differences between the two groups regarding systolic blood pressure (SBP), diastolic blood pressure (DBP), protein and phosphate intake, urinary sodium, potassium, phosphate and urea nitrogen, NEAP, and PRAL. VLPD patients showed at 6 and 12 months a significant reduction of SBP (p < 0.0001), DBP (p < 0.001), plasma urea (p < 0.0001) protein intake (p < 0.0001), calcemia (p < 0.0001), phosphatemia (p < 0.0001), phosphate intake (p < 0.0001), urinary sodium (p < 0.0001), urinary potassium (p < 0.002), and urinary phosphate (p < 0.0001). NEAP and PRAL were significantly reduced in VLPD during follow-up. Conclusion: VLPD reduces intake of acids; nutritional therapy of CKD, that has always taken into consideration a lower protein, salt, and phosphate intake, should be adopted to correct metabolic acidosis, an important target in the treatment of CKD patients. We provide useful indications regarding acid load of food and drinks—the “acid load dietary traffic light”.
Mass Spectrometry-Based Metabolomic and Lipidomic Analyses of the Effects of Dietary Platycodon grandiflorum on Liver and Serum of Obese Mice under a High-Fat Diet
Authors: Park Hye , Park Kab-Tae , Park Edmond , Kim Seung , Choi Myung , Liu Kwang-Hyeon , Lee Choong
Published: January 2017

We aimed to identify metabolites involved in the anti-obesity effects of Platycodon grandiflorum (PG) in high-fat diet (HFD)-fed mice using mass spectrometry (MS)-based metabolomic techniques. C57BL/6J mice were divided into four groups: normal diet (ND)-fed mice, HFD-fed mice, HFD with 1% PG extract-fed mice (HPGL), and HFD with 5% PG extract-fed mice (HPGH). After 8 weeks, the HFD group gained more weight than the ND group, while dietary 5% PG extract attenuated this change. The partial least squares discriminant analysis (PLS-DA) score plots showed a clear distinction between experimental groups in serum and liver markers. We also identified 10 and 32 metabolites in the serum and liver, respectively, as potential biomarkers that could explain the effect of high-dose PG added to HFD-fed mice, which were strongly involved in amino acid metabolism (glycine, serine, threonine, methionine, glutamate, phenylalanine, ornithine, lysine, and tyrosine), TCA cycle (fumarate and succinate), lipid metabolism (linoleic and oleic acid methyl esters, oleamide, and cholesterol), purine/pyrimidine metabolism (uracil and hypoxanthine), carbohydrate metabolism (maltose), and glycerophospholipid metabolism (phosphatidylcholines, phosphatidylethanolamines, lysophosphatidylcholines, and lysophosphatidylethanolamines). We suggest that further studies on these metabolites could help us gain a better understanding of both HFD-induced obesity and the effects of PG.
High Prevalence of Vitamin B12 Deficiency and No Folate Deficiency in Young Children in Nepal
Authors: Ng’eno Bernadette , Perrine Cria , Whitehead Ralph , Subedi Giri , Mebrahtu Saba , Dahal Pradiumna , Jefferds Maria
Published: January 2017

Many children in low- and middle-income countries may have inadequate intake of vitamin B12 and folate; data confirming these inadequacies are limited. We used biochemical, demographic, behavioral and anthropometric data to describe the folate and vitamin B12 concentrations among six- to 23-month-old Nepalese children. Vitamin B12 (serum B12 < 150 pmol/L) and folate deficiencies (red blood cell (RBC) folate < 226.5 nmol/L) were assessed. We used logistic regression to identify predictors of vitamin B12 deficiency. The vitamin B12 geometric mean was 186 pmol/L; 30.2% of children were deficient. The mean RBC folate concentration was 13,612 nmol/L; there was no deficiency. Factors associated with vitamin B12 deficiency included: (a) age six to 11 months (adjusted odds ratio (aOR) 1.51; 95% confidence interval (CI): 1.18, 1.92) or 12–17 months (aOR 1.38; 95% CI: 1.10, 1.72) compared to 18–23 months; (b) being stunted (aOR 1.24; 95% CI: 1.03, 1.50) compared to not being stunted; (c) and not eating animal-source foods (aOR 1.85; 95% CI: 1.42, 2.41) compared to eating animal-source foods the previous day. There was a high prevalence of vitamin B12 deficiency, but no folate deficiency. Improving early feeding practices, including the consumption of rich sources of vitamin B12, such as animal-source foods and fortified foods, may help decrease deficiency.
Contribution of Trans-Fatty Acid Intake to Coronary Heart Disease Burden in Australia: A Modelling Study
Authors: Wu Jason , Zheng Miaobing , Catterall Elise , Downs Shauna , Thomas Beth , Veerman Lennert , Barendregt Jan
Published: January 2017

Trans-fatty acids (TFAs) intake has been consistently associated with a higher risk of coronary heart disease (CHD) mortality. We provided an updated assessment of TFA intake in Australian adults in 2010 and conducted modeling to estimate CHD mortality attributable to TFA intake. Data of the 2011–2012 National Nutrition and Physical Activity Survey was used to assess TFA intake. The CHD burden attributable to TFA was calculated by comparing the current level of TFA intake to a counterfactual setting where consumption was lowered to a theoretical minimum distribution of 0.5% energy. The average TFA intake among adults was 0.59% energy, and overall 10% of adults exceeded the World Health Organization (WHO) recommended limit of 1% energy. Education and income were moderately and inversely associated with TFA intake (p-value ≤ 0.001), with one in seven adults in the lowest income and education quintile having >1% energy from TFA. Australia had 487 CHD deaths (95% uncertainty interval, 367–615) due to TFA exposure, equivalent to 1.52% (95% uncertainty limits: 1.15%–1.92%) of all CHD mortality. The relative impact of TFA exposure on CHD mortality in Australia is limited, but, in absolute terms, still substantial. Policies aimed at reducing industrial TFA exposure can reduce socioeconomic inequalities in health and may therefore be desirable.
Structural Features and the Anti-Inflammatory Effect of Green Tea Extract-Loaded Liquid Crystalline Systems Intended for Skin Delivery
Authors: Bento da Silva Patricia , Fioramonti Calixto Giovana , Oshiro Júnior João , Bombardelli Raisa , Fonseca-Santos Bruno , Rodero Camila , Chorilli Marlus
Published: January 2017

Camellia sinensis, which is obtained from green tea extract (GTE), has been widely used in therapy owing to the antioxidant, chemoprotective, and anti-inflammatory activities of its chemical components. However, GTE is an unstable compound, and may undergo reactions that lead to a reduction or loss of its effectiveness and even its degradation. Hence, an attractive approach to overcome this problem to protect the GTE is its incorporation into liquid crystalline systems (LCS) that are drug delivery nanostructured systems with different rheological properties, since LCS have both fluid liquid and crystalline solid properties. Therefore, the aim of this study was to develop and characterize GTE-loaded LCS composed of polyoxypropylene (5) polyoxyethylene (20) cetyl alcohol, avocado oil, and water (F25E, F29E, and F32E) with different rheological properties and to determine their anti-inflammatory efficacy. Polarized light microscopy revealed that the formulations F25, F29, and F32 showed hexagonal, cubic, and lamellar liquid crystalline mesophases, respectively. Rheological studies showed that F32 is a viscous Newtonian liquid, while F25 and F29 are dilatant and pseudoplastic non-Newtonian fluids, respectively. All GTE-loaded LCS behaved as pseudoplastic with thixotropy; furthermore, the presence of GTE increased the S values and decreased the n values, especially in F29, indicating that this LCS has the most organized structure. Mechanical and bioadhesive properties of GTE-unloaded and -loaded LCS corroborated the rheological data, showing that F29 had the highest mechanical and bioadhesive values. Finally, in vivo inflammation assay revealed that the less elastic and consistent LCS, F25E and F32E presented statistically the same anti-inflammatory activity compared to the positive control, decreasing significantly the paw edema after 4 h; whereas, the most structured and elastic LCS, F29E, strongly limited the potential effects of GTE. Thereby, the development of drug delivery systems with suitable rheological properties may enhance GTE bioavailability, enabling its administration via the skin for the treatment of inflammation.
The Lost Honor of Julius Deutsch: Jewish Difference, “Socialist Betrayal”, and Imperial Loyalty in the 1923 Deutsch-Reinl Trial
Authors: Spitaler Georg
Published: January 2017

In 1922, Julius Deutsch, one of the leading Viennese Social Democrats, spent a weekend in the Strudengau in Upper Austria. In a local inn, he was insulted by a right-wing alpinist, who accused him of being a traitor to the Emperor. The man claimed that Deutsch, along with other “Jewish Revolutionaries”, played a part in overturning the old order and helping to “stab” the Empire’s army “in the back”. Deutsch brought his opponent to trial, in an attempt to present his actions both in the World War and as a State Secretary for Military Affairs in the new Austrian Republic in a better light. However, the provincial courts acquitted the defendant on appeal, following the anti-Semitic arguments of his defending lawyer. Like other trials in the interwar years, the lawsuit unfolded into a “court of injustice”, with contested concepts of “Jewish difference” being performed. In the courtroom, Deutsch, who left the Jewish religious community as a young man, was forced to engage with his Jewish family background. The article focuses on Deutsch’s retrospective narration of the Austro-Hungarian Empire in his courtroom speech and the insights that can be gained about Jewish difference and the antagonistic political arena of the new nation-state of (Deutsch-)Österreich.
State-Level Forestry Cost-Share Programs and Economic Impact of Increased Timber Outputs: A South Carolina Case Study
Authors: Stoots Brandon , Straka Thomas , Phillips Scott
Published: January 2017

Management of family forests in the United States has been long-influenced by public policies and programs that encourage active management on these private lands, especially afforestation of idle lands and reforestation of cut-over lands. Financial incentive programs to encourage family forest reforestation date back to the 1940s, and in the beginning were funded by the federal government. Beginning in the early 1970s, state governments, especially those with strong forestry-based economies, saw a need to offer their own incentives, primarily cost-share programs to increase forest productivity. These programs are considered to be successful, but little research addresses the value and increased timber supply that result from the state investment. Here, we use historical data from the South Carolina Forest Renewal Program (FRP), one of the oldest and well-established state forestry cost-share programs, to determine the incremental timber outputs generated. Marginal analysis was used to produce financial comparison between regeneration options that include cost-share and those that do not. Annual funding for the FRP is currently $1,000,000 and in the long-run five dollars of economic impact is created for each dollar invested, and over a half million tons of additional wood is added to the annual timber supply.
Mapping Extent Dynamics of Small Lakes Using Downscaling MODIS Surface Reflectance
Authors: Che Xianghong , Yang Yaping , Feng Min , Xiao Tong , Huang Shengli , Xiang Yang , Chen Zugang
Published: January 2017

Lake extent is an indicator of water capacity as well as the aquatic ecological and environmental conditions. Due to the small sizes and rapid water dynamics, monitoring the extent of small lakes fluctuating between 2.5 and 30 km2 require observations with both high spatial and temporal resolutions. The paper applied an improved surface reflectance (SR) downscaling method (i.e., IMAR (Improved Modified Adaptive Regression model)) to downscale the daily SR acquired by the Moderate Resolution Imaging Spectroradiometer (MODIS) Terra platform to a consistent 250-m resolution, and derived monthly water extent of four small lakes in the Tibetan Plateau (Longre Co, Ayonggongma Co, Ayonggama Co, and Ayongwama Co)) from 2000 to 2014. Using Landsat ETM+ acquired on the same date, the downscaled MODIS SR and identified water extent were compared to the original MODIS, observations downscaled using an early SR downscaling method (MAR (Modified Adaptive Regression model)) and Wavelet fusion. The results showed IMAR achieved the highest correlation coefficients (R2) (0.89–0.957 for SR and 0.79–0.933 for water extent). The errors in the derived water extents were significantly decreased comparing to the results of MAR and Wavelet fusion, and lakes morphometry of IMAR is more comparable to Landsat results. The detected lake extents dynamic between 2000 and 2014 were analyzed using the trend and season decomposition model (BFAST), indicating an increasing trend after 2005, and it likely had higher correlations with temperature and precipitation variation in the Tibetan region (R2: 0.598–0.728 and 0.61–0.735, respectively).
DInSAR-Based Detection of Land Subsidence and Correlation with Groundwater Depletion in Konya Plain, Turkey
Authors: Caló Fabiana , Notti Davide , Galve Jorge , Abdikan Saygin , Görüm Tolga , Pepe Antonio , Balik Şanli Füsun
Published: January 2017

In areas where groundwater overexploitation occurs, land subsidence triggered by aquifer compaction is observed, resulting in high socio-economic impacts for the affected communities. In this paper, we focus on the Konya region, one of the leading economic centers in the agricultural and industrial sectors in Turkey. We present a multi-source data approach aimed at investigating the complex and fragile environment of this area which is heavily affected by groundwater drawdown and ground subsidence. In particular, in order to analyze the spatial and temporal pattern of the subsidence process we use the Small BAseline Subset DInSAR technique to process two datasets of ENVISAT SAR images spanning the 2002–2010 period. The produced ground deformation maps and associated time-series allow us to detect a wide land subsidence extending for about 1200 km2 and measure vertical displacements reaching up to 10 cm in the observed time interval. DInSAR results, complemented with climatic, stratigraphic and piezometric data as well as with land-cover changes information, allow us to give more insights on the impact of climate changes and human activities on groundwater resources depletion and land subsidence.
An Improved High-Sensitivity Airborne Transient Electromagnetic Sensor for Deep Penetration
Authors: Chen Shudong , Guo Shuxu , Wang Haofeng , He Miao , Liu Xiaoyan , Qiu Yu , Zhang Shuang , Yuan Zhiwen , Zhang Haiyang , Fang Dong , Zhu Jun
Published: January 2017

The investigation depth of transient electromagnetic sensors can be effectively increased by reducing the system noise, which is mainly composed of sensor internal noise, electromagnetic interference (EMI), and environmental noise, etc. A high-sensitivity airborne transient electromagnetic (AEM) sensor with low sensor internal noise and good shielding effectiveness is of great importance for deep penetration. In this article, the design and optimization of such an AEM sensor is described in detail. To reduce sensor internal noise, a noise model with both a damping resistor and a preamplifier is established and analyzed. The results indicate that a sensor with a large diameter, low resonant frequency, and low sampling rate will have lower sensor internal noise. To improve the electromagnetic compatibility of the sensor, an electromagnetic shielding model for a central-tapped coil is established and discussed in detail. Previous studies have shown that unclosed shields with multiple layers and center grounding can effectively suppress EMI and eddy currents. According to these studies, an improved differential AEM sensor is constructed with a diameter, resultant effective area, resonant frequency, and normalized equivalent input noise of 1.1 m, 114 m2, 35.6 kHz, and 13.3 nV/m2, respectively. The accuracy of the noise model and the shielding effectiveness of the sensor have been verified experimentally. The results show a good agreement between calculated and measured results for the sensor internal noise. Additionally, over 20 dB shielding effectiveness is achieved in a complex electromagnetic environment. All of these results show a great improvement in sensor internal noise and shielding effectiveness.
Opportunistic Capacity-Based Resource Allocation for Chunk-Based Multi-Carrier Cognitive Radio Sensor Networks
Authors: Huang Jie , Zeng Xiaoping , Jian Xin , Tan Xiaoheng , Zhang Qi
Published: January 2017

The spectrum allocation for cognitive radio sensor networks (CRSNs) has received considerable research attention under the assumption that the spectrum environment is static. However, in practice, the spectrum environment varies over time due to primary user/secondary user (PU/SU) activity and mobility, resulting in time-varied spectrum resources. This paper studies resource allocation for chunk-based multi-carrier CRSNs with time-varied spectrum resources. We present a novel opportunistic capacity model through a continuous time semi-Markov chain (CTSMC) to describe the time-varied spectrum resources of chunks and, based on this, a joint power and chunk allocation model by considering the opportunistically available capacity of chunks is proposed. To reduce the computational complexity, we split this model into two sub-problems and solve them via the Lagrangian dual method. Simulation results illustrate that the proposed opportunistic capacity-based resource allocation algorithm can achieve better performance compared with traditional algorithms when the spectrum environment is time-varied.
Hybrid Intelligent System to Perform Fault Detection on BIS Sensor During Surgeries
Authors: Casteleiro-Roca José-Luis , Calvo-Rolle José , Méndez Pérez Juan , Roqueñí Gutiérrez Nieves , De Cos Juez Francisco
Published: January 2017

This paper presents a new fault detection system in hypnotic sensors used for general anesthesia during surgery. Drug infusion during surgery is based on information received from patient monitoring devices; accordingly, faults in sensor devices can put patient safety at risk. Our research offers a solution to cope with these undesirable scenarios. We focus on the anesthesia process using intravenous propofol as the hypnotic drug and employing a Bispectral Index (BISTM) monitor to estimate the patient’s unconsciousness level. The method developed identifies BIS episodes affected by disturbances during surgery with null clinical value. Thus, the clinician—or the automatic controller—will not take those measures into account to calculate the drug dose. Our method compares the measured BIS signal with expected behavior predicted by the propofol dose provider and the electromyogram (EMG) signal. For the prediction of the BIS signal, a model based on a hybrid intelligent system architecture has been created. The model uses clustering combined with regression techniques. To validate its accuracy, a dataset taken during surgeries with general anesthesia was used. The proposed fault detection method for BIS sensor measures has also been verified using data from real cases. The obtained results prove the method’s effectiveness.
The Indirect Roles of Roads in Soil Erosion Evolution in Jiangxi Province, China: A Large Scale Perspective
Authors: Xiao Linlin , Yang Xiaohuan , Cai Hongyan
Published: January 2017

As elicitors of terrestrial system change (e.g., land use transformation) through the introduction of anthropogenic causes, the spatial patterns and levels of roads might be more detrimental to the long-term health of ecosystems at a large scale than the road paving itself. This paper reveals the relationship between soil erosion and roads from a large-scale perspective in Jiangxi Province, China. Temporal and spatial distribution characteristics of artificial and natural drive factors of soil erosion alongside roads were addressed. It was found that, from 1990 to 2010, Jiangxi Province experienced an obvious reduction in soil erosion (the mean annual soil erosion rate decreased from 930.8 t·km−2·a−1 to 522.0 t·km−2·a−1), which was positively correlated with road density (p < 0.01). The maximum soil erosion reduction occurred at a distance of 0–1 km from the village roads. The order of soil erosion effects of the four levels of roads is: Village road > county road > provincial/national road. We emphasize that studying the indirect roles of roads in soil erosion is strongly dependent on a comprehensive consideration of historical policy and the economic development stage in a study area. This paper highlights the indirect role of village roads in soil erosion evolution.
Fungal Pretreatment of Willow Sawdust with Abortiporus biennis for Anaerobic Digestion: Impact of an External Nitrogen Source
Authors: Alexandropoulou Maria , Antonopoulou Georgia , Ntaikou Ioanna , Lyberatos Gerasimos
Published: January 2017

In this study the effect of nitrogen (N) supplementation in the fungal pretreatment of willow sawdust (WSD) via the white rot fungus Abortiporus biennis (A. biennis) was studied in terms of the fractionation of lignocellulosic biomass and biochemical methane potential (BMP). Thus, different external nitrogen sources (yeast extract (YE), urea (UR), and ammonium nitrate (AN)) at different ratios (N/C of 1/250 and 1/50) were added and the effect of the above parameters on the chemical composition of WSD during solid-state fermentation (SSF) experiments with A. biennis was assessed and compared to the experiment of fungal pretreatment without N supplementation (N/C was 1/500, control experiment). The results indicated that the addition of an external nitrogen source did not facilitate delignification, regardless of the type of nitrogen source and the ratio of N/C used. On the other hand, enhanced cellulose uptake was observed. Samples of the 28th day of cultivation, with and without N supplementation, were used for BMP tests, where a reduction in methane yield was observed, compared to the control experiment. In addition, a combination of fungal with alkali (20% NaOH w/w dry mass) pretreatment was performed in order to assess the effect of combined pretreatment on the lignocellulosic content and the BMP.
Assessment of Ammonia Volatilization Losses and Nitrogen Utilization during the Rice Growing Season in Alkaline Salt-Affected Soils
Authors: Li Yangyang , Huang Lihua , Zhang Huan , Wang Mingming , Liang Zhengwei
Published: January 2017

The objectives of this study were to evaluate the effects of different fertilizer types and application rates on ammonia volatilization loss and to explore nitrogen distribution and nitrogen use efficiency using the 15N isotope tracing technique in different alkaline salt-affected conditions in the Songnen Plain, Northeast China. The results showed a decreasing trend in ammonia volatilization loss from ammonium nitrate and ammonium sulfate, but not that from urea, as the electrical conductivity gradient increased, whereas the reverse trend was found as the pH gradient increased. Ammonia volatilization loss increased in moderately salt-affected soil compared with that in slightly salt-affected soil, particularly during the tillering stage, regardless of the N fertilizer rate. The percentage of N absorbed by rice plants increased from urea but decreased from the soil as the amount of nitrogen was increased. Interestingly, the N retention rate in soil decreased and rice grain yield and nitrogen agronomic efficiency increased as the amount of nitrogen increased in both salt-affected soil conditions. The nitrogen application amount of highest N physiological efficiency was 225 kg·N/ha. Considering high rice production and a minimal environmental threat, we should fully consider controlling ammonia volatilization losses by adjusting the fertilizer type and the crop stage when the fertilizer is applied.
Comprehensive Evaluation on Employee Satisfaction of Mine Occupational Health and Safety Management System Based on Improved AHP and 2-Tuple Linguistic Information
Authors: Bao Jiangdong , Johansson Jan , Zhang Jingdong
Published: January 2017

In order to comprehensively evaluate the employee satisfaction of mine occupational health and safety management system, an analytic method based on fuzzy analytic hierarchy process and 2-tuple linguistic model was established. Based on the establishment of 5 first-grade indicators and 20 second-grade ones, method of improved AHP and the time-ordered Weighted Averaging Operator (T-OWA) model is constructed. The results demonstrate that the employee satisfaction of the mine occupational health and safety management system is of the ‘general’ rank. The method including the evaluation of employee satisfaction and the quantitative analysis of language evaluation information ensures the authenticity of the language evaluation information.
A Hybrid Fuzzy Inference System Based on Dispersion Model for Quantitative Environmental Health Impact Assessment of Urban Transportation Planning
Authors: Tashayo Behnam , Alimohammadi Abbas , Sharif Mohammad
Published: January 2017

Characterizing the spatial variation of traffic-related air pollution has been and is a long-standing challenge in quantitative environmental health impact assessment of urban transportation planning. Advanced approaches are required for modeling complex relationships among traffic, air pollution, and adverse health outcomes by considering uncertainties in the available data. A new hybrid fuzzy model is developed and implemented through hierarchical fuzzy inference system (HFIS). This model is integrated with a dispersion model in order to model the effect of transportation system on the PM2.5 concentration. An improved health metric is developed as well based on a HFIS to model the impact of traffic-related PM2.5 on health. Two solutions are applied to improve the performance of both the models: the topologies of HFISs are selected according to the problem and used variables, membership functions, and rule set are determined through learning in a simultaneous manner. The capabilities of this proposed approach is examined by assessing the impacts of three traffic scenarios involved in air pollution in the city of Isfahan, Iran, and the model accuracy compared to the results of available models from literature. The advantages here are modeling the spatial variation of PM2.5 with high resolution, appropriate processing requirements, and considering the interaction between emissions and meteorological processes. These models are capable of using the available qualitative and uncertain data. These models are of appropriate accuracy, and can provide better understanding of the phenomena in addition to assess the impact of each parameter for the planners.
Frequency and Pathological Phenotype of Bovine Astrovirus CH13/NeuroS1 Infection in Neurologically-Diseased Cattle: Towards Assessment of Causality
Authors: Selimovic-Hamza Senija , Boujon Céline , Hilbe Monika , Oevermann Anna , Seuberlich Torsten
Published: January 2017

Next-generation sequencing (NGS) has opened up the possibility of detecting new viruses in unresolved diseases. Recently, astrovirus brain infections have been identified in neurologically diseased humans and animals by NGS, among them bovine astrovirus (BoAstV) CH13/NeuroS1, which has been found in brain tissues of cattle with non-suppurative encephalitis. Only a few studies are available on neurotropic astroviruses and a causal relationship between BoAstV CH13/NeuroS1 infections and neurological disease has been postulated, but remains unproven. Aiming at making a step forward towards assessing the causality, we collected brain samples of 97 cases of cattle diagnosed with unresolved non-suppurative encephalitis, and analyzed them by in situ hybridization and immunohistochemistry, to determine the frequency and neuropathological distribution of the BoAstV CH13/NeuroS1 and its topographical correlation to the pathology. We detected BoAstV CH13/NeuroS1 RNA or proteins in neurons throughout all parts of the central nervous system (CNS) in 34% of all cases, but none were detected in cattle of the control group. In general, brain lesions had a high correlation with the presence of the virus. These findings show that a substantial proportion of cattle with non-suppurative encephalitis are infected with BoAstV CH13/NeuroS1 and further substantiate the causal relationship between neurological disease and astrovirus infections.
High Variability Is a Defining Component of Mediterranean-Climate Rivers and Their Biota
Authors: Cid Núria , Bonada Núria , Carlson Stephanie , Grantham Theodore , Gasith Avital , Resh Vincent
Published: January 2017

Variability in flow as a result of seasonal precipitation patterns is a defining element of streams and rivers in Mediterranean-climate regions of the world and strongly influences the biota of these unique systems. Mediterranean-climate areas include the Mediterranean Basin and parts of Australia, California, Chile, and South Africa. Mediterranean streams and rivers can experience wet winters and consequent floods to severe droughts, when intermittency in otherwise perennial systems can occur. Inter-annual variation in precipitation can include multi-year droughts or consecutive wet years. Spatial variation in patterns of precipitation (rain vs. snow) combined with topographic variability lead to spatial variability in hydrologic patterns that influence populations and communities. Mediterranean streams and rivers are global biodiversity hotspots and are particularly vulnerable to human impacts. Biomonitoring, conservation efforts, and management responses to climate change require approaches that account for spatial and temporal variability (including both intra- and inter-annual). The importance of long-term data sets for understanding and managing these systems highlights the need for sustained and coordinated research efforts in Mediterranean-climate streams and rivers.
From Flood Control to Water Management: A Journey of Bangladesh towards Integrated Water Resources Management
Authors: Gain Animesh , Mondal M. , Rahman Rezaur
Published: January 2017

Integrated Water Resources Management (IWRM) is considered as a practical approach in solving water-related problems, which are socio-ecologically complex in nature. Bangladesh has also embraced the IWRM approach against its earlier attempt to flood control. In this paper, we evaluate the current status of IWRM in Bangladesh through the lens of policy shifts, institutional transitions and project transformations using seven key dimensions of IWRM. Looking at IWRM from such perspectives is lacking in current literature. A thorough review of policy shifts suggests that all the key dimensions of IWRM are “highly reflected” in the current policy documents. The dimension of “integrated management” is “highly reflected” in both institutional transition and project-level transformation. Most other dimensions are also recognised at both institutional and project levels. However, such reflections gradually weaken as we move from policies to institutions to projects. Despite catchment being considered as a spatial unit of water management at both institutional and project levels, transboundary basin planning is yet to be accomplished. The participation of local people is highly promoted in various recent projects. However, equity and social issues have received less attention at project level, although it has significant potential for supporting some of the key determinants of adaptive capacity. Thus, the IWRM dimensions are in general reflected in recent policies, institutional reforms and project formulation in Bangladesh. However, to solve the complex water-problems, basin scale management through transboundary cooperation and equity and social issues need to be implemented at institutional and project levels.
3D CFD Modeling of Local Scouring, Bed Armoring and Sediment Deposition
Authors: Török Gergely , Baranya Sándor , Rüther Nils
Published: January 2017

3D numerical models are increasingly used to simulate flow, sediment transport and morphological changes of rivers. For the simulation of bedload transport, the numerical flow model is generally coupled with an empirical sediment transport model. The application range of the most widely used empirical models is, however, often limited in terms of hydraulic and sedimentological features and therefore the numerical model can hardly be applied to complex situations where different kinds of morphological processes take place at the same time, such as local scouring, bed armoring and aggradation of finer particles. As a possible solution method for this issue, we present the combined application of two bedload transport formulas that widens the application range and thus gives more appropriate simulation results. An example of this technique is presented in the paper by combining two bedload transport formulas. For model validation, the results of a laboratory experiment, where bed armoring, local scouring and local sediment deposition processes occurred, were used. The results showed that the combined application method can improve the reliability of the numerical simulations.
Infection Prophylaxis in Peritoneal Dialysis Patients: Results from an Australia/New Zealand Survey
Authors: Campbell Denise J. , Mudge David W. , Gallagher Martin P. , Lim Wai Hon , Ranganathan Dwaraka , Saweirs Walaa , Craig Jonathan C.
Published: January 2017

Background

Clinical practice guidelines aim to reduce the rates of peritoneal dialysis (PD)-related infections, a common complication of PD in end-stage kidney disease patients. We describe the clinical practices used by Australian and New Zealand nephrologists to prevent PD-related infections in PD patients.

Methods

A survey of PD practices in relation to the use of antibiotic and antifungal prophylaxis in PD patients was conducted of practicing nephrologists identified via the Australia and New Zealand Society of Nephrology (ANZSN) membership in 2013.

Results

Of 333 nephrologists approached, 133 (39.9%) participated. Overall, 127 (95.5%) nephrologists prescribed antibiotics at the time of Tenckhoff catheter insertion, 85 (63.9%) routinely screened for nasal S. aureus carriage, with 76 (88.4%) reporting they treated S. aureus carriers with mupirocin ointment. Following Tenckhoff catheter insertion, 79 (59.4%) prescribed mupirocin ointment at the exit site or intranasally, and 93 (69.9%) nephrologists routinely prescribed a course of oral antifungal agent whenever their PD patients were given a course of antibiotics.

Conclusions

Although the majority of nephrologists prescribe antibiotics at the time of Tenckhoff catheter insertion, less than 70% routinely prescribe mupirocin ointment and/or prophylactic antifungal therapy. This variation in practice in Australia and New Zealand may contribute to the disparity in PD-related infection rates that is seen between units.
Meet the New Education and Practice Section Editor
Authors: Rich, PhD, BCTMB, LMT, LSW Grant J.
Published: January 2017

This article serves as an introduction to Grant J. Rich, PhD LMT BCTMB, the new IJTMB Education and Practice Section Editor, and describes his education and experience.
AUTONOMINĖS AGENTO ELGSENOS MODELIAVIMAS REALISTIŠKAME MINIOS SIMULIAVIMO PROCESE
Authors: Cicėnas Vilius
Published: January 2017

Siekiant sukurti tikrovišką minios simuliavimo modelį svarbu sujungti ir derinti įvairias metodikas, kad būtų išgautas unikalus norimas rezultatas, nes universalus algoritmas dar neegzistuoja. Tikroviškumo palaikymas yra dažnai ribojamas kompiuterinių resursų, taigi, renkantis algoritmus ir metodikas, reikia skirti nemažai pastangų planuojant, ištiriant ir ištestuojant galimus simuliavimo būdus. Todėl vis dar yra poreikis modeliui, kurio elgsena būtų lengvai pritaikoma prie simuliacijos poreikių. Straipsnyje glaustai aptarti svarbiausi parametrai, aplinkybės, populiariausios metodikos ir algoritmai, pateiktas algoritmo šablonas autonominiam ir realistiškam agento elgsenos modeliavimui simuliuojamoje aplinkoje.