bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of Potential Immunogenic Epitopes Against SARS-CoV-2
Using In-Silico Method: An Immunoinformatics Study
Authors: Sugumar Shobana , Sankaralingam Subikshaa , Parthasarathy Sathishnath , Nandamuri Chethan Jaya Sai , Ramanathan Shruti
Published: April 2022

Background:

Severe Acute Respiratory Syndrome (SARS-CoV-2), a zoonotic virus, is the pathogenic causal agent for the ongoing pandemic. Despite the lethality of the disease, there are no therapeutic agents available to combat the disease outbreak; and the vaccines currently accessible are insufficient to control the widespread, fast-mutating virus infection.

Objective:

This research study focuses on determining potential epitopes by examining the entire proteome of the SARS-CoV-2 virus using an in-silico approach.

Methods:

To design a vaccine for the deadly virus, the entire proteome of the SARS-CoV-2 virus was screened for identification of potential epitopes in order to identify the potent peptide candidate which is both unique and simultaneously solves the purpose of the vaccine discovery. It is mandatory to identify the suitable B-cell and T-cell epitopes of the observed SARS-CoV-2 Surface Glycoprotein (QKN61229.1). These epitopes were subjected to various tests, including antigenicity, allergenicity, and other physicochemical properties. The T-cell epitopes that met all of the criteria were then subjected to Population Coverage Analysis. It helped better understand the response of epitopes to the target population, compute the conservancy of a peptide, and then cluster them based on their sequence match, MHC binding, and T-cell restriction sites. Lastly, the interactions between the T-Cell Receptor (TCR) and a peptide-MHC were studied to gain a thorough understanding of MHC-restriction to design a peptide-vaccine.

Results:

The results showed that there were 4 B-Cell epitopes, 2 MHC-I epitopes, 4 MHC-II epitopes that qualified all the subjected tests and thus have an affinity to prominent antigens.

Conclusion:

ased on the results obtained from this study, the estimated peptides are a promising candidate for peptide-vaccine design and development.
Herbal-Based Dressings in Wound Management
Authors: Thomas Asha , Nikam Aniket , Giram Prabhanjan , Nagore Dheeraj , Chitlange Sohan
Published: April 2022

Wound management is one of the major global challenges in recent times, and woundassociated
infection has a significant impact on the healthcare economy worldwide. Wounds can be
acute or chronic type, also diabetic, trauma, accidental, burn wounds and minor cuts, bruises, and
rashes, etc. One of the primary treatment options available in these conditions are the use of suitable
dressing materials to cover the wound and accelerate the healing process. Since ancient times,
according to archaeological theories, medicinal plants and oils have been employed for the treatment
of wounds. Today researchers across the globe are focusing their efforts on fabrication of
novel dressing materials that can provide the most effective treatment, easy exchange of nutrients,
and absorb exudate from the wounds. Very lately, various research groups are also concentrating
on the design and development of herb-loaded wound dressings, as herbal preparations contain
numerous phytoconstituents with a broad spectrum of pharmacological properties when compared
to synthetic drugs and also due to the perceived notion that herbal products are generally safe, even
when administered over prolonged periods. They contain numerous bioactive that can act on the
various phases of the wound healing process, providing an ideal environment for the healing process.
The present review discusses the numerous approaches that are employed for the preparation
of dressing materials incorporated with plant-derived phytoconstituents/extracts. This review also
provides an insight into the healing process and wound healing agents derived from medicinal
plants and oils. The review can serve as a database for researchers working in this field and can
help them to select the most appropriate dressing material for the effective delivery of herbal preparations
in the management of wounds.
Does Nicotine from Passive Smoking and Foods Protect Against
Parkinson’s Disease?
Authors: Faramarzi Elnaz , Fathalizadeh Arezoo , Sanaie Sarvin , Mirghafourvand Mojgan , Reyhanifard Anita , Rahnemayan Sama , Mahmoodpoor Ata
Published: April 2022

Background:

There is generally a strong link between smoking, more particularly,
passive smoking, and the occurrence of various illnesses and health-related disorders. Also, there
is a globally recognized epidemiological link between smoking and Parkinson’s disease (PD).
However, the current data on passive smoking are contradictory. Thus, this paper extracted the
inconsistent existing studies to systematically shed light on the slightly ambiguous protective
properties of dietary nicotine and passive smoking as influential factors against PD.

Method:

This systematic review was registered in PROSPERO (CRD042020160707). Two independent
researchers searched through the following databases: PubMed, Cochrane Library,
Scopus, Ovid, Embase, Google Scholar, and ProQuest to find relevant dissertations and theses.
This study involved the data of papers published until 30th September, 2020. The Newcastle-
Ottawa scale (NOS) was used for case-control and cohort studies for quality assessment. The
study extracted cases without a history of smoking and the number of patients with PD in the
workspace, home, and lifetime and organized them based on each research. The study implemented
Q-statistic to investigate the selected papers based on statistical heterogeneity.

Result:

In total, four cohorts and five case-control papers were included. Our findings indicated
that lifetime exposure to smoking had a protective effect against PD risks (OR: 0.84; 95% CI:
0.70-0.99; p =0.04). However, the settings, workspace, home exposure, and PD risk did not display
to have any considerable relationship. It should be noted that the studies on the relationship
between dietary nicotine and PD risks have revealed the protective effect of nicotine-rich foods,
like potatoes, tomatoes, and peppers, on PD risks.

Conclusion:

In light of the observational studies covered in this paper, its findings should receive
an organized interpretation while identifying the relevant mechanisms of this association.
Influence of Heating on the Physico-Biochemical Attributes of Milk
Authors: Goswami Tridib Kumar , De Baishakhi , Pandey Suravi , Pou Jolvis , Sharma Sadananda P. , Raghavan Vijaya G.S.
Published: April 2022

Background:

Milk, the fluid secreted by the female of all mammalian species, fulfills
the complete nutritional and energy requirements. Milk is a single balanced diet enriched in
physiologically important proteins and peptides, enzymes, enzyme inhibitors, immunoglobulins,
growth factors, hormones, and antibacterial agents. Milk can be converted to different dairy
items that occupy an important place in confectioneries and beverages and thus are subjected to
various processing conditions.

Objective:

This review aims to discuss how the processing conditions affect the physicobiochemical
and nutritional attributes of milk protein and influence its functionality with a major
focus on heating or thermal treatment.

Methods:

Detailed literature surveys with keywords ‘thermal effect of milk proteins’, ‘dairy
chemistry’, ‘Maillard reactions have been done in food science, food chemistry, dairy science,
functional foods journals, PubMed, and Scopus for gathering information on thermal effects on
milk proteins. Out of 25 shortlisted review and research articles, 20 most relevant ones were cited
and enlisted as references.

Results:

Due to thermal treatment during dairy processing, the chemical characteristics of milk
proteins are altered because of chemical changes like glycation, aggregation and denaturation.
Chemical modifications influence the functionality, digestibility, and nutritional quality of milk
proteins.

Conclusion:

Novel milk processing technologies viz. ohmic and microwave heating, pulsed electric
field, high hydrostatic pressure, microfiltration and ultrasound find applications in dairy processing.
Such non-thermal technologies do not involve heat to kill the microbes; thus reducing
the detrimental effect of conventional heat treatments on milk quality.
Prospects for Neurotrophic Factor-Based Early Intervention in Schizophrenia:
Lessons Learned from the Effects of Antipsychotic Drugs on
Cognition, Neurogenesis, and Neurotrophic Factors
Authors: Khan Mohammad M. , Parikh Vinay
Published: April 2022

Although reducing psychotic symptoms in schizophrenia has been a major focus of therapeutic
interventions for decades, improving cognition is considered a better predictor of functional
outcomes. However, the most commonly prescribed antipsychotic drugs (APDs) show only marginal
beneficial effects on cognition in patients with schizophrenia. The neural mechanisms underlying cognitive
disturbances in schizophrenia remain unknown that making drug development efforts very challenging.
Since neurotrophic factors are the primary architects of neurogenesis, synaptic plasticity,
learning, and memory, the findings from preclinical and clinical studies that assess changes in neurogenesis
and neurotrophic factors and their relationship to cognitive performance in schizophrenia, and
how these mechanisms might be impacted by APD treatment, may provide valuable clues in developing
therapies to combat cognitive deficit in schizophrenia. Numerous evidence produced over the
years suggests a deficit in a wide spectrum of neurotrophic factors in schizophrenia. Since schizophrenia
is considered a neurodevelopmental disorder, early intervention with neurotrophic factors may be
more effective in ameliorating the cognitive deficits and psychopathological symptoms associated with
this pathology. In this context, results from initial clinical trials with neurotrophic factors and their future
potential to improve cognition and psychosocial functioning in schizophrenia are discussed.
A Causal-Pathway Phenotype of Chronic Fatigue Syndrome due to Hemodialysis in Patients with End-Stage Renal Disease
Authors: Maes Michael , Asad Halah Nori , Al-Hakeim Hussein Kadhem , Moustafa Shatha Rouf
Published: April 2022

Background:

End-stage renal disease (ESRD) is associated with fatigue and physio-somatic symptoms.

Objective:

To delineate the associations between severity of fatigue and physio-somatic symptoms and glomerular filtration rate, inflammatory biomarkers, and Wnt/catenin-pathway proteins.

Methods:

The Wnt-pathway related proteins β-catenin, Dickkopf-related protein 1 (DKK1), R-spondin-1, and sclerostin were measured by ELISA technique in 60 ESRD patients and 30 controls. The Fibromyalgia and Chronic Fatigue Syndrome (FF) Rating Scale was used to assess the severity of FF symptoms.

Results:

ESRD is characterized by a significant increase in the total FF score, muscle tension, fatigue, sadness, sleep disorders, gastro-intestinal (GI) symptoms, and a flu-like malaise. The total-FF score was significantly correlated with serum levels of urea, creatinine, and copper (positively), and β-catenin, eGFR, hemoglobin, albumin, and zinc (inversely). The total-FF score was associated with the number of total dialysis and weekly dialysis sessions, and these dialysis characteristics were more important in predicting FF scores than eGFR measurements. Partial Least Squares analysis showed that the FF score comprised two factors that are differently associated with biomarkers: a) 43.0% of the variance in fatigue, GI symptoms, muscle tension, sadness, and insomnia is explained by hemoglobin, albumin, zinc, β-catenin, and R-spondin-1; and b) 22.3% of the variance in irritability, concentration and memory impairments by increased copper and cations/chloride ratio, and male sex.

Conclusion:

ESRD patients show high levels of fatigue and physio-somatic symptoms, which are associated with hemodialysis and mediated by dialysis-induced changes in inflammatory pathways, the Wnt/catenin pathway, and copper.
Implementasi Kebijakan Pemberdayaan Masyarakat Pesisir dalam Mendukung Pertahanan Maritim Indonesia (Studi Peraturan Daerah Kota Surabaya Nomor 10 Tahun 2016 Tentang Rencana Pembangunan Jangka Menegah Daerah Kota Surabaya Tahun 2016-2021)
Authors: Rudiawan Beni , Sumartono Sumartono , Mardiyono Mardiyono , Saleh Choirul
Published: April 2022

This study aims to analyzes the empowerment of coastal communities in Surabaya as planned by the Surabaya City Government (Pemkot) in the Regional Regulators (Perda) Number 10 of 2016 concerning on Medium-Term Development Region Plans (RJPMB) of Surabaya City year 2016-2021. Data were collected by descriptive analysis research methods and approaches qualitative. The data were validated by interviews, observations, and documentations that shows the implementation of coastal community empowerment policies who was done by the Surabaya City Government to support Indonesia's maritime defense that has not been done. Based on Grindle's policy implementation theory approach and the empowerment model community by Hyman, the study revealed that coastal communities can be empowered to become one of the elements of Indonesia's maritime defense force and the deterrent againts the threats of the transnational crimes that use marine and coastal areas as an alternative media.
Analisis Faktor-Faktor yang Mempengaruhi Kinerja Pegawai di Subbag Rumah Tangga Biro Umum dan Keuangan Universitas Negeri Malang
Authors: Hidayatunnafiq Faul
Published: April 2022

Employee performance has an important role in supporting the success and success of the organization. The background of this research is the low performance of the teaching staff in the Household Subdivision of the State University of Malang (UM). Some indicators of performance decline include employee discipline at work, and ineffective performance of the UM Household Subdivision. The problem is thought to be related to factors that affect performance, for this reason it is necessary to analyze the factors that affect the performance of employees in the UM Household Subdivision. This study aims to analyze the effect of training, competence, leadership perception, compensation, experience, and motivation on performance both directly and through work motivation as a mediator variable. The results of this study indicate that training has a significant effect on performance, followed by compensation and leadership perceptions. Activities that are relevant to improving employee performance are further intensifying education and training programs, increasing compensation, and strengthening leadership management at UM.
Durable Resistance to Rice Blast Mediated by Race-nonspecific Genes in Rice: A Mini Review
Authors: Okuno Kazutoshi
Published: April 2022

Rice blast is a major biotic constraint of rice worldwide, that causes a serious threat to rice production. Genetic improvement of blast resistance is one of important objectives in rice breeding programs. Race-specific resistance genes (R-genes) confer complete resistance to rice blast fungus, but a breakdown of resistance mediated by R-genes has been frequently caused by new races of blast pathogen. To avoid the risk of genetic vulnerability, the use of race-nonspecific resistance has been concentrated in Japanese upland rice varieties whose resistance has been maintained for a long time. However, linkage drag between genes underlying race-nonspecific resistance and undesired traits has hindered its use. Among QTLs detected, a single recessive resistance gene, pi21 was identified by map-based cloning and characterized. The use of pi21 has improved durable resistance in rice breeding programs in Japan. Three QTLs conferring race-nonspecific resistance to rice blast were detected on chromosomes 4 and 12. Among them, a single recessive gene, pi21 was isolated by positional cloning and characterized. This allele has been used for genetic improvement of durable blast resistance through DNA marker-assisted selection in rice breeding programs in Japan and Africa Rice Center.
On the Woody Species Diversity and Population Structure of the Gola Natural Vegetation, Eastern Hararghe, Oromia, Ethiopia
Authors: Hussein Abdulbasit
Published: April 2022

The present study has analyzed the diversity and population structure of woody species in Gola natural vegetation. So far, the expected form of vegetation diversity relationships with different land use in study sites has not been known. A total of 73 quadrats were established systematically within three land-use types. Vegetation parameters and species type were recorded. There were 52 woody species found in total. The Fabaceae family had the most species, accounting for 15.3% of the total plant species. The PA site had Shannon’s diversity index value that was significantly higher than the other two land-use types (P= 0.042). The dynamics of woody plants diversity about land use is of major need for sustainable management of forests, and the present study provides valuable information for forest management, and it may help to develop testable hypotheses on other tropical forests.
Prophylactic Effect of Cucumis melo on Chromium Vi-Induced Male Albino Rats
Authors: Malathi G.
Published: April 2022

The production of reactive oxygen species (ROS), which induce oxidative stress in humans, is linked to the negative effects of Chromium 6.The protective action of Cucumis melo L. fruit extracts was evaluated in this study in an animal model of hematological and biochemical parameters, which was induced by chromium VI (K2 Cr2 O7). The purpose of this study was to analyse the efficacy of Cucumis melo L. on chromium VI (K2 Cr2 O7)-induced rats. For 42 days, male albino rats (160–20 g) were given the stated oral LD50 dosage of chromium VI (K2Cr2O7) (10 mg/kg body weight). After 42 days, chromium-induced rats were administered with two different concentrations of Cucumis melo L. and ascorbic acid (250 mg/kg, 500 mg/kg body weight) for 7 days. Following therapy, blood was drawn and analysed for a variety of biochemical markers.The results revealed that ingestion of either plant extract, ascorbic acid, or their combination on chromium 6 induced rats significantly increase the activity of Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST) and decreased the activity of Gamma Glutamyl transferase (γ-GT) was recorded. This study has proven that fruit extract particularly its combination with ascorbic acid has a potential prophylactic effect. Cucumis melois vital for modifying the Chromium (VI) induced toxicity on male albino rats. Indeed, the recommended fruits should be consumed to the Chromium (VI) deposited harmful region since they may protect cells from environmental stress.
The Effects of Costus speciosus Root Extract on Cultured Human Lung Cancer Cells, A549
Authors: Omar Abdulkader Shaikh
Published: April 2022

Cancer has become one of the most common clinical reasons of death all over the world, with more than nine million deaths each year. Throughout the history, many traditional plants have been used to treat various types of cancers. The scientifically researched anticancer plants, with over 3000 species are novel candidates for anticancer drugs, because more than 80% of society believes in traditional medicine as its cure. The aim of this study was to determine the effects of Costus speciosus root extract on human lung cancer (LC) cells (A549). Treatment of (A549) cells with ethyl acetate Costus root extract significantly lowered the cell viability. IC50 was calculated, after 24, 48 and72 h, with concentration of 25, 40, 70 and 100 μg/100μl. The MTT assay was used to test the viability of the cells. The effect of (EACR) on cell adhesion and migration was demonstrated in a wound healing assay, mitochondrial membrane potential was detected in a JC-1 assay, and DNA damage and repair were demonstrated in a comet assay. There was a noticeable reduction in (LC) development. Experiments underlying the anti-cancer activity of (EACR) on (A549) cells may be regarded as one of the most promising targets for novel cancer treatment strategies (LC).
Differential Effects of Solvents on Extraction, Pharmacognostic Evaluation and Antioxidant Activity of Long Pepper Piper longum Fruit Extract
Authors: Mittal Amita
Published: April 2022

The present study proposed differential effect of solvents on extraction, pharmacognostic evaluation and antioxidant activity of Long pepper (Piper longum) fruit extract. The bio-analytes present in P. longum fruit were extracted by dissolving powder fruit in water, ethanol, methanol, acetone, and ethyl acetate. Further, the extracts were dried using rotavapor at 55 °C and used to assess the phytochemical analysis where total phenolic compounds (TPCs) were evaluated using Folin-Ciocalteu Assay. Additionally, ascorbic acid content was measured, and Fourier Transform Infrared Spectroscopy (FTIR) analysis was performed to predict the presence of various compounds based on their surface functional groups. Further, antioxidant efficiency was determined by considering DPPH radical scavenging activity. The quantitative measurements of the TPC and ascorbic acid reveal the presence of the pharmacognostic compounds in P. longum, which is also supported by FTIR analysis. The FC assay test confirmed the highest polyphenols (181.0 ± 8.69 mg GAE/g) in ethyl acetate extract, while methanolic extract showed the maximum ascorbic acid content (1.51 ± 0.067 mg AE/g). Methanolic and ethyl acetate-based extraction process showed great results than other solvents as they showed maximum DPPH radical scavenging activity (% degradation), 81.57 %, followed by ethyl acetate (79.35%). The obtained results announced P. longum extract can be used as a raw material in pharmaceutical industries and local levels to improve health conditions.
On the Efficacy of the Gene, Juxtaposed with Another Zinc Finger Protein 1 (JAZF1) in the Development of Type 2 Diabetes Mellitus among Indians
Authors: Dev Kapil
Published: April 2022

Type 2 diabetes mellitus (T2DM) is a chronic disorder characterized by pancreatic beta-cell dysfunction and insulin resistance. The present study was designed to understand the association of genetic variations in the JAZF1 gene with T2DM in the Indian population. The polymorphic study was conducted by PCR-RFLP methods. Further, the biochemical parameters were collected for statistical analysis on the semi-structured questionnaire, and correlation with the polymorphism was done by using SPSS software. The significant differences were observed between T2DM cases and controls in triglycerides, HbA1c, T-cholesterol, LDL-C, BMI, systolic and diastolic BP, PPG, FPG, while no significant differences were observed in HDL-C, WHR. Our results suggested that the JAZF1 rs864745 variant is significantly associated with T2D among the Indian population. The present study concludes that the association of genetic variations and biochemical factors play a vital role in T2DM risk and its prevalence.
Population Status, Distribution, Threats and Conservation of the Blackbuck, Antilope cervicapra in South Asia: An Updated Review
Authors: Tahir Rabia
Published: April 2022

Blackbuck, Antilope cervicapra, is a diurnal ungulate species with distinct sexual dimorphism and spellbinding beauty. Male blackbuck has mesmeric beauty with its unique darker coat, showing the increased intensity of color with age. Blackbuck is endemic to Pakistan, Nepal, India and Bangladesh but now its population is reduced to a few areas. Threats such as hunting, stress, habitat loss, diseases, poaching, road accidents, habitat fragmentation, interspecific competition, predation pressure etc., have reduced the population size of blackbuck to a threatened level. Therefore, different conservation strategies are underway to increment its count for improvement of faunal diversity, tourism development and dispersal of the local culture in South Asia. Captive breeding of species is the most efficacious conservation strategy in South Asia so far. Furthermore, various rules and regulations along with strategies like hormone-mediated conservation by injections of prostaglandin and artificial insemination are assisting the species by increasing its birth rate. Genetic studies, introduction to non-endemic but suitable habitat and religious affiliation of communities also contributed to blackbuck conservation. Current conservation practices are helping to conserve the blackbuck but are associated with a few concerns also, thereby proper management, planning, monitoring of conservation practices is required. Population size, distribution range, threats confronted by species, conservation practi
Educational Right for Children with Special Needs: A comparison between Malaysia and Thailand
Authors: Othman Muhammad Fikri , Rahmat Nur Ezan , Abdul Aziz Norazlina , Sukbunpant Sasipin
Published: April 2022

Even though Section 28 of the Persons with Disabilities Act 2008 provides the educational right for persons with disabilities, especially children with special needs, their educational right is not protected effectively since the laws and regulations governing the educational right of children with special needs in Malaysia are scattered. This paper aims to compare the practice of laws relating to special education between Malaysia and Thailand. The authors conduct a doctrinal analysis to complete this paper where textbooks and journal articles related to special education for children with special needs in Malaysia and Thailand are analysed.
Keywords: Educational Right; Special Education; Children with Special Needs; Persons with Disabilities
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i19.2451
Impact of Physical Learning Environment Towards Students’ Performance at Taylor’s University
Authors: Othman Ahmad Ridzwan , Ruslan Nurwafa Alia , Zahrah Wahyuni
Published: April 2022

The learning environment needs attention as this space is closely related to students' well-being and learning performance. The ideal learning environment is always changing as innovations in technologies, teaching strategies, and design philosophies require continuous measurement and reassessment. This paper focused on the assessment of the physical learning environment that influences students' satisfaction level at Taylor's University. The result revealed that students’ satisfaction levels highly rely on spatial features (room layout and furniture) and ambient features (temperature and acoustics) of the classrooms. The findings and conclusion give an insight concept of the ideal learning spaces of the 21st-century.
Keywords: 21st century classroom; Ideal environment; Learning performance
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i19.3099
A Qualitative Study on the Experiences of Clinical Accompaniment among Nursing Distance Learners
Authors: Yusof Suzana , Sharif Abdullah Sharifah Shafinaz , Sham Fatimah , Wilandika Angga
Published: April 2022

Clinical accompaniment is essential to provide nursing students with a foundation to apply to practice. This study aimed to explore the e-PJJ nursing students' perception regarding their clinical accompaniment during their clinical placement. This qualitative phenomenology study was conducted using in-depth interviews and focus group discussion among eleven Bachelor of Nursing (e-PJJ) students. This study revealed three themes: Supervision in Clinical Placement; Student-centered Learning, and Feeling Stress as a Distance Learner. The need for clinical accompaniment among e-PJJ students was minimal, but they required written guidelines to facilitate them during a clinical attachment.
Keywords: Experience, clinical accompaniment, distance learners, qualitative study.
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i19.3127
The Impact of Remote Education on University Students at Cadi Ayyad University in Morocco: Situation and perceptions
Authors: Iflahen Fatima-Zohra , Benkhallouq Fatima-Zohra
Published: April 2022

This study analyzes the impact of remote education on the students of open-access institutions affiliated with Cadi Ayyad University in Marrakech, Morocco. This study is based on the collection of qualitative and quantitative data from questionnaires answered by 1760 students, 193 professors and 51 administrative executives. To ensure a better understanding of the impacts of the pandemic on a context afflicted by vulnerability, this study chooses four focal points to its analysis of remote education’s impact on the aforementioned population: Perceptions, Costs, Student Experience and Attendance. In so doing, this study encourages the production of scholarship on educational experiences in times of crisis in Global South countries.
Keywords: Remote Education; Lockdown; Higher-Education; UCA.
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i19.3195
Green Pause in a City: Design elements of a pocket park in Kuala Lumpur
Authors: Hussein Hazreena , Khai Jhung Loh , Zhang Heng
Published: April 2022

Pocket Park, a small-scale open urban green space valued as community assets, is introduced as an alternative for urban parks within limited space constraints. However, research on pocket parks, explicitly in Kuala Lumpur, is scarce compared to Western cities. This study looked into the design elements of Laman Tun Perak to investigate its significance to the urbanites. The objectives are to identify how the pocket park is utilised and determine its design elements. The design elements of a pocket park are connectivity and permeability, safety, comfort, and activities.
Keywords: Design elements, Laman Tun Perak, Pocket Park, Urban Green Spaces
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
Mental Health Literacy among Parents of Children with Autism Spectrum Condition: A concept paper
Authors: Ilias Kartini , Shalihin Siti Amirah Syarafana , Che Daud Ahmad Zamir , Hayasaka Tomonari
Published: April 2022

Parents of children with Autism Spectrum Condition (ASC) are highly exposed to mental health problems. Low mental health literacy is one of the barriers in accessing mental health services provided, leaving mental health problems untreated, yet mental health literacy among parents of children with ASC is poorly understood. This conceptual paper of the ongoing study aims to emphasize the significance of understanding the mental health literacy concept within the specific population. Findings will be able to highlight the implications of mental health literacy among parents of children with ASC and will also provide further opportunities to explore the literature gap.
Keywords: mental health literacy; mental health; parents with Autism Spectrum Condition (ASC) children; concept paper
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i19.3252
Noise and Cognitive Performance in Developing Brain using Functional MRI: A scoping review protocol
Authors: Ahmad Anwar Bashah Farahnaz , Yusoff Ahmad Nazlim , Abdul Wahab Nor Alaudin , Armijo-Olivo Susan
Published: April 2022

This protocol aims to guide the process to conduct a scoping review on noise and cognitive performance in developing the brain using functional MRI. This review benefits future research by providing a clear mapping of evidence. This protocol adhered to Arksey and O'Malley's scoping review methodological framework. A Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) extension for Scoping Reviews (PRISMA-ScR) was implemented to report the full scoping review. This protocol facilitated a well-structured mapping of evidence. The findings from scoping review will be made public through conferences and journal publications.
Keywords: Scoping review protocol; Adolescents’ cognitive performance; Noise; functional MRI.
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i19.3256
Challenges on the Implementation of Cook-Chill System in School Foodservice
Authors: Mat Yusoff Norhayati , Muhammad Rosmaliza , Abd Ghani Fatimah , Roselina Elsa
Published: April 2022

This paper aims to identify the challenges of the cook-chill system implementation in school foodservice. In this qualitative approach, data were gathered through interviews with food contractors in seven different school in Selangor. Three issues, including a lack of awareness about the cook-chill system, inadequate management, and lack of training, were discovered using qualitative content analysis (QCA). The respondents believed the system was better suited for airlines or hospitals than school foodservice operations, which produced a large volume of meals everyday. This study could contribute a better understanding on the complexity of the cook-chill system, particularly for the school foodservice.
Keywords: School foodservice; cook-chill system; challenges; implementation
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i19.3265
Developing a Framework of Sensory Environment for Autism Centre
Authors: Ghazali Roslinda binti , Md Sakip Siti Rasidah , Samsuddin Ismail , Samra Heba
Published: April 2022

The learning environment is critical in developing the skill and mental of children with autism. However, designers are often unaware of the sensory issues and designing a unique environment that would affect learning process. The paper's objective is to identify the main factor in creating the physical learning environment for autism.  Partial Least Square Structural Equation Modelling (PLS-SEM) was conducted to develop a framework of the sensory environment. It is hoped that this paper could be an impressive contribution to technical agencies and designers during their design stage, thus creating a better physical learning environment supported with sensory design features.
Keywords: Sensory environment; autism; physical learning environment;  
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i19.3266
Digitization of Business for Small And Medium-Sized Enterprises (SMEs)
Authors: Abu Hasan Norraidah , Abd Rahim Memiyanty , Ahmad Saidah Hamizah , Meliza Meliza
Published: April 2022

Digitalization is critical for the long-term viability of small businesses in the new economy. As global digitalization accelerates, Malaysian SMEs must embrace the digital economy to contribute to economic growth. A critical issue confronting SMEs in the aftermath of the COVID-19 pandemic is adopting a digital business model. This study examines the importance of embedding digital technology into business models among SMEs, which has been shown to increase long-term productivity and sustainability. Technology adoption will help close the productivity gap between SMEs and large corporations by increasing capacity and capability for greater competitiveness and innovation.
Keywords: Small-Medium Enterprise (SME); digitalization; resource-based view; performance
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i19.3270
Practicalities of Strata Lease Schemes in Malaysia
Authors: Zainal Nur Huzaifah , Samsudin Salfarina , Md Azmi Fatin Afiqah , Amin Siddiqa
Published: April 2022

This paper aims to review the implementation of the strata leasing concept in Malaysia. The study's objectives are to identify the legislations for developing strata lease schemes and determine the law supporting the strata leasing concept. Multiple case studies were conducted on all strata lease schemes in Penang. The finding shows several Malaysian laws required to develop and administrate strata lease schemes. The study proved that current legislation supports Penang's strata lease schemes effectively, and the true character of the strata lease scheme is identified as the result of the study.
Keywords: strata lease scheme; land law; residential buyer; urban development
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer-review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians), and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i19.3271
Face Validation of Learning Malaysian Sign Language Questionnaire (L-MySL-Q): Malaysian Sign Language (MySL) pro forma as a third language for adolescents
Authors: Tengku Jamaluddin Tengku Intan Baizura , Mohd Rashid Syar Meeze , Broome Emma , Mohd Hassan Naffisah
Published: April 2022

Malaysian Sign Language (MySL) uses visual-manual modalities for delivering information and communicating involving movements of the finger, hand, arm gestures, and facial expressions. A newly-developed instrument tool: Learning-MySL-Questionnaire (L-MySL-Q) from validated questionnaires [Rogers 1995; ELQ, University of Nottingham, UK] consisting of the diffusion model to gauge willingness and readiness for students to adopt MySL as a third language undergone face validation upon completion of Introduction to MySL Pro Forma leson. Findings showed positive feedback from respondents in comparison to pre-intervention among typical children and adolescents. This comprehensive pro forma inculcates a fun learning process while inculcating patriotism among learners.  
Keywords: inclusive communication, Malaysian Sign Language, third language, adolescents
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI:https://doi.org/10.21834/ebpj.v7i19.3273
Procesos alternativos transdisciplinares: ciudades saludables y la nueva normalidad
Authors: Chincaro Siljha
Published: April 2022

Se reflexiona sobre las oportunidades que se presentan en el campo de la investigación en Arquitectura, Urbanismo y Diseño en el contexto contemporáneo, a partir de la comprensión de nuevas dinámicas interdisciplinarias y transdisciplinarias para afrontar problemas críticos del hábitat humano. Se cuestiona sobre métodos y herramientas que permitan entender la espacialidad desde otros enfoques. La comprensión de las inteligencias múltiples y la neurociencia permiten un acercamiento a lo “humano” desde una perspectiva integradora y dinámica.
Mammalian MutY Homolog (MYH or MUTYH) is Critical for Telomere Integrity under Oxidative Stress
Authors:   University of Maryland School of Medicine, Baltimore, MD, USA, Gupta Aditi , Hwang Bor-Jang ,   University of Maryland School of Medicine, Baltimore, MD, USA, Benyamien-Roufaeil Daniel ,   University of Maryland School of Medicine, Baltimore, MD, USA, Jain Sara ,   University of Maryland School of Medicine, Baltimore, MD, USA, Liu Sophie ,   University of Maryland School of Medicine, Baltimore, MD, USA, Gonzales Rex ,   University of Maryland School of Medicine, Baltimore, MD, USA, Brown Robert A. ,   University of Maryland School of Medicine, Baltimore, MD, USA, Zalzman Michal ,   University of Maryland School of Medicine; The Center for Stem Cell Biology and Regenerative Medicine; Marlene and Stewart Greenbaum Cancer Center, Baltimore, MD 21201, USA, Lu A-Lien ,   University of Maryland School of Medicine; Marlene and Stewart Greenbaum Cancer Center, Baltimore, MD, USA
Published: April 2022

Telomeres consist of special features and proteins to protect the ends of each chromosome from deterioration and fusion. The telomeric DNA repeats are highly susceptible to oxidative damage that can accelerate telomere shortening and affect telomere integrity. Several DNA repair factors including MYH/MUTYH DNA glycosylase, its interacting partners Rad9/Rad1/Hus1 checkpoint clamp, and SIRT6 aging regulator, are associated with the telomeres. MYH prevents C:G to A:T mutation by removing adenine mispaired with a frequent oxidative DNA lesion, 8-oxoguanine. Here, we show that hMYH knockout (KO) human HEK-293T cells are more sensitive to H2O2 treatment, have higher levels of DNA strand breaks and shorter telomeres than the control hMYH+/+ cells. SIRT6 foci increase at both the global genome and at telomeric regions in H2O2-treated hMYH+/+ cells. However, in untreated hMYH KO HEK-293T cells, SIRT6 foci only increase at the global genome, but not at the telomeric regions. In addition, the hMYH KO HEK-293T cells have increased extra-chromosomal and intra-chromosomal telomeres compared to the control cells, even in the absence of H2O2 treatment. After H2O2 treatment, the frequency of extra-chromosomal telomeres increased in control HEK-293T cells. Remarkably, in H2O2-treated hMYH KO cells, the frequencies of extra-chromosomal telomeres, intra-chromosomal telomeres, and telomere fusions are further increased. We further found that the sensitivity to H2O2 and shortened telomeres of hMYH KO cells, are restored by expressing wild-type hMYH, and partially rescued by expressing hMYHQ324H mutant (defective in Hus1 interaction only), but not by expressing hMYHV315A mutant (defective in both SIRT6 and Hus1 interactions). Thus, MYH interactions with SIRT6 and Hus1 are critical for maintaining cell viability and telomeric stability. Therefore, the failure to coordinate 8-oxoG repair is detrimental to telomere integrity.
On the Reflection of Schopenhauer’s Ethics in Fly by Riichi Yokomitsu
Authors: Yan Zheng
Published: April 2022

The short story Fly, published in 1923 in the Japanese magazine Bungeishunju, is the Japanese neo-sensationalism writer Riichi Yokomitsu’s maiden work. The full text is only more than three thousand five hundred words, but its content is humorous, profound implication, vivid image, it is really a short and pithy life drama. This paper will take the characters in Fly as the research object to discuss the embodiment of Schopenhauer’s ethics in the text.
The Exploration of Su Shi’s Life Values
Authors: Sun Qikai
Published: April 2022

Su Shi is a famous Chinese poet who is a household name and arguably one of the greatest exponents of Chinese poetry, as well as being highly accomplished in poetry, lyrics, prose, calligraphy and painting. Through the study of Su Shi, we can find out the unique thoughts of this great writer on the values of life, which are important for our understanding of the development of poetry and the social history of the Northern Song Dynasty.