bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALYSIS OF CONCENTRATIONS OF RISK AND TOXIC ELEMENTS IN SHEEP MILK FROM AREA OF SLOVAKIA WITH POTENTIALLY UNDISTURBED ENVIRONMENT
Authors: Pšenková Martina , Toman Róbert , Almášiová Simona
Published: April 2022

Concentration of toxic metals in milk, especially in industrial regions, may serve as a direct bioindicator of the quality of milk, which is an important food in human diet. The aim of this study was to find actual contamination of selected area of Slovakia and to determine the effect of lactation stages on the concentration of risk and toxic elements in sheep´s milk of Tsigai breed. Monitoring of environment was performed by sampling of soil, feed, and milk samples from 400 ewes. Selected elements in feed and milk were detected using the AAS-HG, AES-ICP, AAS-ETA, AAS-AMA, and AAS-F and in soil samples by ICP-OES. Concentrations of toxic elements (As, Hg, Pb, Ni) were found in the soil samples, which corresponded to MRL, and their content was not reflected in the samples of feed and milk of sheep and were below the LOQ. The effect of lactation stage was statistically significant only in case of Ca (P<0.05), where a significant increase in concentration of this element was found throughout the lactation period. A statistically significant increase of concentrations of Se, Mg, Zn and Fe (P<0.05) in sheep milk was recorded only in the late stage of lactation. Pearson´s correlation analysis showed a several very strong and positive correlation relationships in individual lactation stages of sheep. The very low concentrations, below LOQ of selected toxic elements in milk confirmed, that level of contamination of the selected area of Slovakia is very low, and milk from this area of Slovakia is in good hygienic quality and it is safety for direct consumption or for further processing.
REDUCE THE SULPHUR DIOXIDE CONTENT OF WINE BY BIOLOGICAL PROCESS IN RELATION TO THE CONTENT OF POLYPHENOLIC SUBSTANCES
Authors: Fišera Miroslav , Šustová Květoslava , Tvrzník Pavel , Velichová Helena , Fišerová Lenka , Lukášková Eva , Kráčmar Stanislav
Published: April 2022

In recent years, many papers have paid attention to the bioactive compounds, particularly to the antioxidant activity of polyphenolic compounds in food and beverages, due to their positive effect on human body. Therefore, the phenolic compounds and their antioxidant capacity become an important quality parameter, especially in niche markets concerned with health benefits. 

Wine is an excellent source of various classes of polyphenols. The phenolic compounds are responsible for the sensory characteristics, particularly colour, astringency, bitterness, and aroma, too. Another very important ingredient in the wine is added the sulphur dioxide, which has the role to protect these reductive components of wines.

Sulphur dioxide has the effects of antioxidant, antimicrobial and preservative that is mutually merging. However, it is possible to increase the stability of the complex of biologically active substances (BAS), as holders of natural antioxidant capacity. The present contribution brings opportunities rather than full elimination, but a substantial reduction of the content of sulphur dioxide, which protects the wine during the entire technological process of manufacture and treatment. The dosage of sulphur dioxide can be reduced in its values from 15 to 40% of the total health of the authorized maximum sulphur dioxide content of wine.
Nyolc év az Európai Szemorvostársaság vezetőségében
Authors: Németh János
Published: April 2022

A szerző az Európai Szemorvostársaság (SOE) vezetőségében végzett nyolcéves munkájáról számol be. Legfontosabb eredményei, a Magyar Szemorvostársaság képviseletén túl, a SOE Pilot Committee for Public Eye Health munkabizottság megszervezése és működtetése, amely számos területen ért el áttörést és új eredményeket: Európai Regionális WHO Munkaértekezlet megtartása, európai adatgyűjtések a vakságmegelőzés és látásrehabilitáció kapcsán végzett tevékenységekről valamint a tűzijáték okozta szemsérülésekről, szimpóziumok és ülések szervezése a szem-egészség témakörében, valamint irányelvek kidolgozása és publikálása a vakságmegelőzés és a myopia kezelése témákban.
Immunfluoreszcens vizsgálatok hegesedő kötőhártya-gyulladásokban
Authors: Bakos Noémi , Fodor Eszter
Published: April 2022

Célkitűzés: Krónikus, hegesedő kötőhártya-gyulladás miatt gondozott betegcsoportban elvégzett immunfluoreszcens vizsgálatok eredményének felmérése. Betegek és módszerek: 23 krónikus, hegesedő kötőhártya-gyulladással jelentkező beteg immunfluoreszcens vizsgálatának eredménye került áttekintésre retrospektív módon. A betegeknél minden esetben direkt immunfluoreszcens vizsgálat (DIF) történt kötőhártyamintából. 11 esetben indirekt immunfluoreszcens vizsgálat, egy esetben pedig salt-split-skin vizsgálat is történt. Eredmények: A 23 betegen 30 alkalommal elvégzett DIF-tesztből 16 volt pozitív (53,3%). Ebből 13 esetben nyálkahártya pemphigoid (OcMMP) igazolódott, 4 esetben egyéb oculodermalis kórkép (pemphigus vulgaris, paraneoplasiás-pemphigoid, bullosus pemphigoid és lineáris IgA-betegség). 14 esetben a mintában kórjelző eltérés nem igazolódott. Az OcMMP-s betegek DIF-vizsgálata során lineáris IgG-lerakódás fordult elő a leg­gyakrabban (100%). Az IIF-teszt 11 esetben került elvégzésre és 4 esetben lett pozitív (36,4%). Megbeszélés: A DIF alacsony szenzitivitása és specificitása nem teszi lehetővé, hogy csupán DIF-teszt alapján megállapítsuk vagy kizárjuk az OcMMP-t, ugyanakkor közelebb visz a diagnózishoz és a megfelelő terápia kiválasztásához, ezért krónikus, hegesedéssel járó kötőhártya-gyulladásban mindenképp ajánlott a DIF elvégzése a terápia beállítása előtt. Kiegészítő diagnosztikus vizsgálatként az IIF-vizsgálatot is érdemes elvégezni.
Direkt orális antikoaguláns profilaxis mellett kialakult kétoldali retinalis vénás ágelzáródás COVID-19-fertőzést követően
Authors: Tóth Gábor , Sándor Gábor László , Geiszelhardt Balázs , Mohammadpour Behnam , Resch Miklós , Nagy Zoltán Zsolt , Papp András
Published: April 2022

A szerzők egy koronavírus-betegség 2019 (COVID-19) fertőzést követően kialakult olyan kétoldali retinalis vénás elzáródás (RVO) esetéről számolnak be, ami direkt orális antikoaguláns (DOAC) profilaxis szedése mellett alakult ki. A 69 éves nőbeteg mindkét szemén homályos látás jelentkezett a PCR-vizsgálattal igazolt COVID-19-fertőzés után egy hónappal. Anamnézisében 15 éve kezelt hipertónia és pitvarfibrilláció miatt 5 év óta napi kétszer 150 mg dabigatran szedése szerepelt. A trombofíliaszűrés során az antikardiolipin-antitestek emelkedett értéket mutattak. Esetbemutatásunkkal arra hívjuk fel a figyelmet, hogy a súlyos COVID-19-fertőzés RVO-t okozhat még azoknál a betegeknél is, akik hosszú távú DOAC-profilaxisban részesülnek. Lehetséges, hogy COVID-19-fertőzött betegek számára nem előnyös a DOAC-profilaxis az RVO elkerüléséhez.
The Role Of Uric Acid And Hscrp In Predicting Metabolic Syndrome
Authors: Cankar Dal Hayriye , Acar Yasar
Published: April 2022

Aim: Metabolic syndrome is a group of diseases characterized by the coexistence of cardiometabolic risk factors such as abdominal obesity, dyslipidemia, glucose intolerance, and high blood pressure. Metabolic syndrome is a common disease that can lead to high mortality with cardiovascular complications. Many studies are ongoing for laboratory parameters that can be used in the early diagnosis of this syndrome, but for daily clinical use and the diagnostic criteria, any parameter has not been revealed yet. We planned to carry out this study to predict the usability of uric acid and HSCRP in clinical practice, which have been reported to be associated with metabolic syndrome in the literature. Material and Methods: Patients with metabolic syndrome who applied to Ankara Training and Research Hospital’s Internal Medicine department outpatient clinic for any reason within nine months were included in the study group. In the same period, completely healthy cases who applied to the outpatient clinic for any reason were included in the control group. Demographic data, physical examination findings, anthropometric measurement results, biochemical parameters, and HSCRP levels of the cases were recorded. Metabolic syndrome and the control group were analyzed for uric acid and HSCRP values. SPSS 25.0 was used for statistical analysis. The data were evaluated within the 95% confidence interval, and p<0.05 was considered significant. Results: In the study conducted that with a total of 174 patients, including 95 patients with metabolic syndrome and 79 healthy patients, the mean uric acid level of the metabolic syndrome group (5.22±1.39mg/dl) was significantly higher than that of the control group (4.35±1.11mg/dl) (p<0.01). With the ROC curve, the uric acid cut-off value for detecting metabolic syndrome incidence was found to be 5.45mg/dl (specificity 89.9%; sensitivity 51.6%). Its positive predictive value was 86%, and its negative predictive value was 60.7%. The mean HSCRP levels of the metabolic syndrome group (4.72±3.54mg/L) were found to be significantly higher than the control group (3.30±3.21mg/L) (p<0.01). Conclusion: Serum uric acid and HSCRP levels in the study group with metabolic syndrome were significantly higher than in the control group. This syndrome, which is very common today, can lead to various outcomes in terms of mortality and morbidity; when the early diagnosis is delayed, it constitutes an important part of health expenditures. We believe that early diagnosis with laboratory parameters that can be very practical in daily practice will prevent metabolic syndrome complications. Keywords : Metabolic syndrome, obesity, systemic inflammation, uric acid, HSCRP
As a different cause of kidney failure, liver failure, and fever: Leptospirosis
Authors: Gok Mehmet Gokhan , Arslan Ahmet Melih
Published: April 2022

Leptospirosis is the most common bacterial zoonosis globally, especially in tropical and temperate regions with heavy rainfall. Infection into humans occurs in direct contact with the urine of the sick animals’ contact with the environment contaminated with urine. The clinical spectrum of leptospirosis is quite broad. It is subclinical in 90% of cases. Multiple organ failure, especially kidney, liver, and lung, can be seen in 5-10% of cases [1-2]. Weil’s disease is the most severe form of leptospirosis. It progresses with liver dysfunction, acute renal failure, thrombocytopenia, and fever; If left untreated, it can be fatal at 1-5% [3]. In our case, a 60-year-old patient with fever, hyperbilirubinemia, acute renal failure, and thrombocytopenia will be discussed. Keywords: Liver dysfunction, acute renal failure, thrombocytopenia, fever
Wave Functions for the Electron and Positron
Authors: Traill Declan
Published: April 2022

The Wave/Particle duality of particles in Physics is well known. Particles have properties that uniquely characterize them from one another, such as mass, charge and spin. Charged particles have associated Electric and Magnetic fields. Also, every moving particle has a De Broglie wavelength determined by its mass and velocity. This paper shows that all of these properties of a particle can be derived from a single wave function equation for that particle. Wave functions for the Electron and the Positron are presented and principles are provided that can be used to calculate the wave functions of all the fundamental particles in Physics. Fundamental particles such as electrons and positrons are considered to be point particles in the Standard Model of Physics and not considered to have a structure. This paper demonstrates that they do indeed have structure and that this structure extends into the space around the particle’s center (in fact, they have infinite extent), but with rapidly diminishing energy density with the distance from that center. The particles are formed from Electromagnetic standing waves, which are stable solutions to the Schrödinger and Classical wave equations. This stable structure therefore accounts for both the wave and particle nature of these particles. In fact, all of their properties such as mass, spin and electric charge, can be accounted for from this structure. These particle properties appear to originate from a single point at the center of the wave function structure, in the same sort of way that the Shell theorem of gravity causes the gravity of a body to appear to all originate from a central point. This paper represents the first two fully characterized fundamental particles, with a complete description of their structure and properties, built up from the underlying Electromagnetic waves that comprise these and all fundamental particles.
An Analysis of Obesity and Associated Health Implications in Colorado and Mississippi States in U.S.A.
Authors: Herath Bandara Saman Janaranjana , Kodippili Asitha
Published: April 2022

The study tries to investigate the obesity and obesity related health implications of Colorado and Mississippi States to see the significant factors affecting obesity in each state to propose effective and doable policy suggestions to the states, especially to Mississippi state. The study follows logit analysis using Behavior Risk Factor Surveillance Systems (BRFSS) survey data of 2018. The individual data reported for the states were used for the analysis. The statistical package of STATA was used for the analysis. The analytical results show that physical exercise (EXER), number of sleeping hours (SLEP), and education (EDUC) play a major role in combatting obesity. Also, the impact of smoking (SMOK), alcohol consumption (DRNK), and obesity -related diseases ((DISE). The large differences in value between Colorado and Mississippi indicate the significance of these variables and how they could be used in Mississippi. Thus, Mississippi needs to go for efficient and effective policy implications to facilitate more for physical exercises, and education. Both states report that obesity-related illnesses have a significant impact on obesity. Thus, health programs on these diseases would be required to reduce obesity.
Anatomical study of the anterolateral ligament in Romanian population
Authors:   Bagdasar-Arseni Clinical Emergency Hospital, Bucharest, Romania, Paraschiv Radu , Dinache George ,   Carol Davila University Central Emergency Military Hospital, Bucharest, Romania                     Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Pogarasteanu Mark E ,   Carol Davila University Central Emergency Military Hospital, Bucharest, Romania                     Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Lazarescu Sorin ,   Bagdasar-Arseni Clinical Emergency Hospital, Bucharest, Romania
Published: April 2022

"Abstract: The purpose of this paper was to evaluate the existence of the anterolateral ligament of the knee in the Romanian population. Multiple studies have investigated the anterolateral structures of the knee, but there is some inconsistency regarding the existence of the anterolateral ligament. Materials and methods: A cadaver dissection study was performed on 10 knees (5 left and 5 right), 3 males and 2 females Results: The anterolateral ligament was observed in all 10 knees. The mean length was 32±6mm, the width was 5.1±2 mm, and the thickness at the articular line was 1.1±5 mm. Conclusions: A 100% presence was found, with a slight difference from the length, width, and thickness in other countries, race not being a decisional factor in differences. Keywords: anterolateral ligament, anatomy, lateral collateral ligament, dissection "
Updates in teenage acute intentional self-poisonings
Authors:   Pediatric Poisoning Center, “Grigore Alexandrescu” Emergency Clinical Hospital for Children, Bucharest, Romania                                                                                                                                 Department of Pediatrics, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Stanca Simona , Bostan Irina ,   Pediatric Poisoning Center, “Grigore Alexandrescu” Emergency Clinical Hospital for Children, Bucharest, Romania, Stanca Horia ,   Department of Ophthalmology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Danielescu Ciprian ,   Department of Ophthalmology, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Munteanu Mihnea ,   Department of Ophthalmology, “Victor Babeș” University of Medicine and Pharmacy, Timisoara, Romania, Teodoru Adrian ,   Department of Ophthalmology, “Lucian Blaga” University, Faculty of Medicine, Sibiu, Romania
Published: April 2022

"Abstract: Acute intentional poisonings represent an important part of emergency pediatric pathology, as well as a psychiatric one, with an escalation tendency over the past years. The current paper consists of a descriptive prospective study, which took place over a period of 12 months, and included 342 children within the age range 6-18 years, that presented in the Emergency Unit, being subsequently treated as in-patients of the Pediatric Poisoning Center of “Grigore Alexandrescu” Emergency Clinical Hospital for Children. The number of pediatric acute intentional poisonings hospitalized within the time frame of the study was 819 cases. Of these, 342 were intentional, which constitutes a percentage of 41.75%, and 477 were accidental, i.e. 58.24%. The etiology of the acute intentional poisonings is varied; however, medication (54.38%), ethanol (28.65%) and drugs of abuse (12.28%) were predominant. A higher frequency of acute intentional poisonings was noticed in girls (65.49%) as compared to boys (34.50%), probably due to the particularities the psychological profile of this sex shown at this age, i.e. higher emotional instability and display tendency. Out of the total number of acute intentional poisonings, we identified 20 cases of suicide attempts, which represent 5.83% of the total acute voluntary poisonings. Moreover, some of these cases constitute a repeated suicide attempt. The studied group included 30 cases of chronic substance abuse and 6 chronic alcohol abuse cases, with ages within the 13-17 years range, 12 of which were females and 24 males. Out of the 36 chronic substance/alcohol abuse patients, 4 were social cases. Pediatric acute intentional self-poisonings are an important public health issue, alarming through its consequences and through its hidden neuropsychiatric and behavioral substrate. This is due to the fact that adolescence is a period of marked emotional fragility, sensitive to all sorts of influences. Keywords: self-poisoning, teenager, psychiatric disorders, alcohol, substances of abuse"
The interactions between risk factors for ischemic stroke
Authors:   ", Nica Silvia ,   Emergency University Hospital of Bucharest, Bucharest, Romania  ",   ",   Carol Davila",   ",   University of Medicine and Pharmacy Bucharest, RomaniaDavila”", Nica Remus ,   Central Military Emergency University Hospital “Dr. Carol Davila”, Toma Mihai ,   Central Military Emergency University Hospital “Dr. Carol Davila”, Cimponeriu Danut ,   University of Bucharest, Bucharest, Romania, Cirstoiu Florin ,   "Emergency University Hospital of Bucharest, Bucharest, Romania                                                    ""Carol Davila"" University of Medicine and Pharmacy Bucharest, Romania", Cimpoesu Diana ,   "Grigore T. Popa" University of Medicine and Pharmacy Iasi, Romania
Published: April 2022

"Abstract: Stroke has a significant prevalence in Romania. The predisposition for this multifactorial disease is partially known. The aim of this study is to investigate the predisposition for stroke in Romanian population. Material and methods. We selected cases with recent ischemic stroke (n=100) and healthy control subjects (n=100). The AGTR1 A1166C (rs5186) polymorphism was genotyped by restriction of amplicons with Dde I endonuclease. Results. Active cigarette smoking (O.R. =6.92, p=0.0001) or presence of the AT1R C variant (O.R. =6.69, p=0.0006) in overweight or obese women significantly increase the risk for ischemic stroke. The diagnosis of stroke (71.5 vs 68 years old) or T2DM (63.39 vs 60.77 years old) was recorded at an older age in women compared to men (p<0.05). Obesity considered independent (O.R. =4.22, p<0.05) or in association with T2DM (O.R. = 10.16, p=0.0002) confers the highest risk of stroke when compared to women. Conclusions. Obesity in association with T2DM confers the highest risk of stroke for men when compared to women. Active cigarette smoking or AT1R C variant significantly increase the risk for stroke in women with a high BMI compared with controls. Keywords: stroke, AT1R, BMI, cigarette smoking"
Quality of life impairments and stress coping strategies during the Covid-19 pandemic isolation and quarantine. A Web-based survey
Authors:   Carol Davila Univeristy Central Emergency Military Hospital Bucharest, Romania, Vasiliu Octavian
Published: April 2022

"Abstract: Isolation and quarantine during the Covid-19 pandemic affected the lifestyle and daily functioning of the population around the world, leading to social, psychological, and economic changes which further multiplied the stress related to the threat of coronavirus contagion by adding financial, relational, academic, professional and mental health vulnerabilities. To assess the impact of isolation and quarantine over the quality of life in the Romanian population, we conducted a Web-based survey focused on the evaluation of stress level, perception of lifestyle changes, communication patterns, mental health, major concerns, perception of one’s future, but also on the preferred coping strategies that people have used to deal with the isolation stress. The answers were collected during one month and the results for the first 2 weeks of quarantine/isolation were compared with the results after one month of such regimen. Several recommendations based on the survey results analysis were formulated regarding possible strategies for decreasing the impact of stress factors over the general population and specific, vulnerable groups. Keywords: Covid-19, pandemic, quality of life, stress coping strategies, functional impairment, depressive disorders, anxiety disorders, behavioral addictions"
Chest CT-scan findings in COVID-19 patients: Relationship between the duration of symptoms and correlation with the oxygen saturation level
Authors:   Chemical Injuries Research Center, System Biology and Poisoning Institute, Baqiyatallah University of Medical Science, Tehran, Iran, Qaasemya Aryaa , Khajehpoura Hojjatollah ,   Chemical Injuries Research Center, System Biology and Poisoning Institute, Baqiyatallah University of Medical Science, Tehran, Iran, Gouvarchin Galehb Hadi ,   Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran, Dorostkarb Ruhollah ,   Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran, Assadollahic Ehsan ,   School of Medicine, Babol University of Medical Sciences, Iran, Alidadid Soudabeh ,   Department of Medical Physics. Babol University of Medical Sciences, Iran
Published: April 2022

"Abstract: Purpose: This study is carried out to evaluate the diagnostic value of using common features of computed tomography (CT) imaging in COVID-19 disease, and to assess the relationship between blood oxygen saturation level and severity of CT findings. Materials and Methods: In this retrospective study, the chest CT of 173 test-confirmed COVID-19 patients have been evaluated to determine the patterns of involvement in multiple phases of illness. Then, the correlation between the severity of lung involvement and oxygen saturation levels has been assessed. Results: The chest CT results show that 87.6% of patients had GGO, which was the most common pattern in our findings. 83.8% of patients had bilateral lung involvement with the dominant multifocal and peripheral distribution. peribronchovascular involvement was also a common finding in our study (47.2 %). we found predominantly peribronchovascular view in 3 patients (1.7%), pleural effusion in 4 patients (2.3%), lymphadenopathy in 10 patients (5.8%), the tree in the bud in one patient (0.6%), and nodules in 4 patients (2.3%). We also found that GGO is the most common pattern during the early phase of the disease (97.4% of early phase cases). However, in the intermediate and late phases, consolidation and crazy paving patterns are more common. Moreover, our findings indicate that there is a significant relationship between oxygen saturation level and Total Severity Score, with the exclusion of the young adult patients (20-40 years). Conclusion: Relying on chest CT-scan findings apart from the oxygen saturation level is sufficient for the diagnosis and management of patients with COVID-19 pneumonia. Keywords: COVID-19, pneumonia, spiral CT, diagnosis, treatment, Real-Time RTPCR"
Mass shooting incidents: evolution of preventive procedures, preparation, treatment, and medical care supply
Authors:   251 Air Force General Hospital, Athens, Greece, Naoum Symeon , Spyropoulos Vasileios ,   251 Air Force General Hospital, Athens, Greece
Published: April 2022

"Abstract: Mass shootings incidents occur with increasing frequency over time. Studying these cases proved that, despite their diversity, several common features could be taken into account in the early detection and possible prevention of certain future cases. Accepting that such incidents may occur anywhere and anytime, societies need to be prepared for their more effective response. Informing citizens about the best way to react to a mass shooting event is considered crucial and essential. The ""Run-Hide-Fight"" guideline/directive seems to be the most appropriate guideline given to the public. Proper training, of both the Suppression Forces and the emergency medical care providers, is considered of utmost importance. The role of the Incident Commander, regarding the incident management, as well as the external bleeding control of the injured people, are factors of paramount importance in trying to mitigate the casualties from such an incident. The alertness of both citizens and organizations/structures may lead to early detection of potential perpetrators and thereby averting a mass shooting incident. To achieve increased survival and a reduced number of casualties from a mass shooting event it is vital proper education be present at all levels. The response to a mass shooting event should be imprinted in an Emergency plan. Such a plan should have been decided and made, by the Security and Suppression Forces, the Healthcare Institutions, and the Public Safety Answering Point. Keywords: mass shooting incident, first responder, active bleeding, tourniquet, Incident Commander"
Peptide nucleic acid (PNA) as a novel tool in the detection and treatment of biological threatening diseases
Authors:   Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran, Hashemzadeh Mohammad S.
Published: April 2022

"Abstract: Peptide Nucleic Acids (PNAs) are nanostructures similar to nucleic acid molecules (synthetic DNA/RNA analogs) wherein the negatively charged backbone (sugar-phosphate) present in DNA/RNA molecules is replaced by a backbone without polyamide or peptide charge. Later, it was found that PNAs containing both purine and pyrimidine bases form highly stable duplexes with DNA and RNA. Although it is not as stable as 2PNA/DNA triplexes containing a homopyrimidine strand, it is still more stable than DNA/DNA and/or DNA/RNA duplexes. The unique characteristics of PNAs add new aspects to these nanostructures relative to conventional analogs to make them appropriate for molecular biology studies. The most important applications include the use of these nanostructures in the detection and treatment of diseases caused by threatening biological agents using the antisense/antigen technology and as genetic regulator drugs. Keywords: Peptide Nucleic Acids (PNAs), synthetic DNA analog, genetic regulator drugs, antisense-antigen technology"
Legislative Effectiveness From a Legislative Drafter’s Perspective
Authors: Gulati Devika
Published: April 2022

Legislative Effectiveness From a Legislative Drafter’s Perspective: Analysing the Transgender Persons (Protection of Rights) Act, 2019

This article discusses the effectiveness of Transgender persons (Protection of Rights) Act, 2019 and tests the legislation against Dr. Maria Mousmouti’s Effectiveness Test. The author first attempts to trace the real purpose of the Act in terms of specific and broad purposes, and the micro, meso and macro goals. Secondly, the author examines the content of the Act in terms of the legislative techniques used, compliance and enforcement mechanism, and legislative communication. Thirdly, the author studies the context of the Act in terms of its coherence, accessibility and the choice of superstructure.

Finally, the author checks the Act against the element of result where she examines the monitoring, review and evaluation clauses of the legislation, and the mechanism to collect and assess the legislative results.
Stichting Cartel Compensation: welke logica voor de rechtstreekse werking van de antitrustregels?
Authors: Blockx J.
Published: April 2022

Stichting Cartel Compensation: welke logica voor de rechtstreekse werking van de antitrustregels?

In een erg technisch arrest bevestigt het Hof van Justitie nogmaals de belangrijke rol van de nationale rechter bij de handhaving van het Europese mededingingsrecht. De rechtstreekse werking van artikel 101 VWEU is daarbij niet afhankelijk van het al dan niet bestaan van een kader voor de administratieve handhaving van die bepaling. Misschien even opmerkelijk is dat het Hof van Justitie in dit arrest niets zegt over de rol die private handhaving kan spelen als afschrikkingsfactor ten aanzien van kartelvorming.

HvJ 11 november 2021, C-819/19, ECLI:EU:C:2021:904 (Stichting Cartel Compensation en Equilib Netherlands).
O Impacto do Programa Nacional de Apoio à Gestão Administrativa e Fiscal dos Municípios Brasileiros (PNAFM) na eficiência fiscal das prefeituras
Authors: Pereira José Wilas
Published: April 2022

O arranjo institucional decorrente da Constituição Federal de 1988 estabelece novas bases para o federalismo brasileiro alterando profundamente as relações intergovernamentais. Estados e municípios ganharam centralidade no processo decisório sobre políticas públicas, algo que exige dos entes, capacidades gerenciais e fiscais para a implementação das intervenções. Entre os esforços nacionais para elevar a performance fiscal dos municípios, à criação do PNAFM é o mais recente e busca fazê-lo através do incentivo financeiro. Nesse contexto, torna-se oportuno analisar o possível impacto do programa sobre o público-alvo, uma vez que, a avaliação das políticas e/ou programas públicos torna-se uma necessidade primária para garantir a continuidade dos investimentos e promover a reformulação de ações ineficientes e ineficazes. Tomando o resultado operacional do exercício financeiro como proxy de eficiência fiscal, a presente pesquisa buscou por meio do modelo de regressão, através do método da “diferença em diferenças”, investigar o impacto dessa ação nos entes participantes do programa. Observou-se, ao final, que o PNAFM teve baixa adesão, com apenas 11% da expectativa inicial atingida, o que sugere deficiências de formulação do programa e baixa capilaridade da política pública. Além disso, o déficit operacional per capita cresceu nos municípios no patamar superior a 70% no comparativo entre 2001 e 2012, reduzindo a capacidade de atendimento às demandas sociais por parte do poder público local. Por fim, mesmo com um aumento (melhoria) de 30% no resultado operacional do grupo de tratamento após a implementação do programa, este dado não se mostrou estatisticamente significativo. Com isso, a hipótese de que o PNAFM produziu resultados positivos sobre os municípios aderentes não encontra sustentação estatística nos dados.
ASSERTIVIDADE E FIDEDIGNIDADE DAS RECEITAS ORÇAMENTÁRIAS DOS MUNICÍPIOS CATARINENSES
Authors: Mendes Dreone Mendes
Published: April 2022

Esta pesquisa apresenta uma abordagem qualitativa que tem por objetivo verificar o nível de assertividade da previsão de arrecadação orçamentária dos Municípios catarinenses, em diferentes níveis de classificação orçamentária, por meio da apuração do cálculo do índice de assertividade. Discute-se os dados informados diretamente pelos Municípios ao Tribunal de Contas e ao Ministério da Fazenda, órgãos externos a Administração Pública Municipal, um vinculado a esfera federal e outro a estadual. Também serão verificados qual o nível de fidedignidade das informações fornecidas pelos Entes, comparados os dados enviados aos diferentes órgãos, e também com o valor calculado a partir da legislação vigente. Verificando-se quais Municípios que para o mesmo dado, apresentam valores diferentes a depender de quem é o receptor da informação. Apresenta-se também os Municípios com maior variação entre a receita estimada e arrecadada tanto positiva quanto negativa. Trazendo ao final do estudo um panorama da qualidade das informações fornecidas pelos Municípios, e quão precisas são suas estimativas orçamentárias
Syndromic Approach: The Febrile Stroke
Authors: Sidhwa Kamo
Published: April 2022

Infectious disease practitioners are often tasked with evaluating fever in the setting of acute stroke. Although fever is often considered a host response to acute ischemia, underlying infections are identified in approximately one-fourth of cases. Physicians should be vigilant in evaluating for infectious triggers of stroke, as well as potential infectious consequences of ischemia and direct infectious invasion of the central nervous system leading to stroke.
Comercial yeast samples DNA extraction using universal kit
Authors: Robiatush Sholichah Arrohmah  , Radinal Kautsar
Published: April 2022

Yeast is a microorganism that is relatively difficult to obtain its DNA mass. This is caused by the content of cell walls with a thick and rigid composition, such as chitin. This study aims to provide information on the best concentration and purity of the DNA extraction results of various types of commercial yeast in different samples weight. The method used is based on Universal Kit procedure with modification. This study indicates that differences in concentration or sample weight do not affect the DNA concentration and purity ratio value of each yeast sample. Each best result obtained from Jago (Rhizopus oligosporus), Raprima (Rhizopus oligosporus) and Fermipan (Saccharomyces cerevisiae) in 50 mg sample, NKL (Saccharomyces cerevisiae) yeast in 40 mg. Recomendation weight samples to extract DNA of Rhizopus oligosporus and Saccharomyces cerevisiae isolates are between 40 mg to 50 mg. The contamination factor causes the difference in the value of purity in each sample during DNA extraction.
CRITICAL DIALOGUES Human Rights, Democracy and Pandemic Perspectives
Authors:   GRUPO DE PESQUISA CULTURA, DIREITO E SOCIEDADE DGP CNPQ UFMA, Staiano Maria Francesca
Published: April 2022

The present publication is brought about by the joined researchers efforts to share common concerns and scientific analysis to the global current pandemic Covid-19, which discussions were held abridged during the International Online Congress “Critical Dialogues on Pandemic Perspectives: Global Justice, Rule of Law and Human Rights” comprising professional and theoretical reflections and synergy to promote international academic and scientific exchanging cooperation on the current global pandemic context on reflecting, thinking and scrutinizing government’s, public policies and decision-making process and innovation in the fighting against direct and collateral damages caused by the Covid19’s social and institutional impacts, considering transnational implications to the political, economic and the rule of law systems from a Global Justice approach and, locally to human rights’ protection. The Sustainable Development Goals achievements cannot ignore the technological challenges of The Industrial Revolution 4.0, the precariousness of labor relations, the growing of an economic inequality, and a return to extremist nationalism. Yet, the pandemic context, after two years, forces us to think about the ascendancy of intramural violence, since social distance ends up challenging everyone, however, with outstanding, material, and dissimilar conditions since it tends to the social elimination of the socially vulnerable. Despite the needed corporate and public adopted strategies, disenfranchisement and excessive administrative measures have been settled, reframing, and mitigating international relations pulling geopolitical, economic, and technological strings in the multipolar world. For those finding facts, we are invited to discuss the new challenges and outcomes from a pandemic perspective to the Global Justice, Rule of Law, and Human Rights questioning if and how human rights can be ensured and mainstreamed in the taken prevention and recovery measures in democratic societies. The International Congress was organized to celebrate the tenth anniversary of the Research Group Culture, Law and Society ((DGP CNPQ UFMA), and was upheld by The Graduate Law Program of the Universidade Federal do Maranhão (PPGDIR/UFMA), together with the Graduate Law Program of the Faculdade de Direito de Vitória (PPGD/FDV), the Chinese Study Center of the Instituto de Relaciones Internacionales of the Universidad Nacional de la Plata, and the Institute for International Legal Studies of the National Research Council of Italy, by each representative, we are pleased to WELCOME you to the Critical Dialogues on Pandemic Perspectives, discussing Human Rights, Democracy and Pandemic Perspectives.
O estudo de instalações elétricas: uma análise à luz das inteligências múltiplas de Gardner
Authors: Ortiz Gabriel Santos , Denardin Luciano
Published: April 2022

Este artigo apresenta um relato de experiência sobre atividades práticas que abordaram, na educação básica, o tema de instalações elétricas. As atividades fizeram parte de uma pesquisa qualitativa maior sobre o pluralismo metodológico e inteligências múltiplas no ensino de circuitos elétricos. Assim, além do intuito de compartilhar a proposta, este trabalho tem como objetivo compreender o potencial das atividades no estímulo às diferentes inteligências e no aumento da motivação e do protagonismo dos estudantes. Como participantes da pesquisa, envolveram-se aproximadamente 30 estudantes do Ensino Médio de uma escola pública de Porto Alegre, Rio Grande do Sul, Brasil. Os dados foram obtidos por meio de observações, registro em áudio e registros fotográficos. Como método de análise, optou-se pela Análise Textual Discursiva. Pela natureza da atividade, observou-se que a proposta estimulou o uso de habilidades muitas vezes não exploradas no ensino tradicional. A análise sugere que ao menos três inteligências foram estimuladas durante as atividades (inteligência espacial, corporal-cinestésica e inteligência interpessoal). Por fim, constatou-se também o grande envolvimento e motivação dos estudantes com a atividade, reforçando a importância de continuarmos trabalhando em busca de uma educação mais ativa, colaborativa e significativa.
A História da Ciência e a Simulação Computacional no ensino e na aprendizagem da Física
Authors: Rosa Pedro , De Souza Aguinaldo
Published: April 2022

Neste trabalho mostraremos como é possível vincular a História da Ciência e a Simulação Computacional para criar um ambiente de autonomia para o estudante em sua aprendizagem, pensando o estudante como responsável pelo seu caminhar formativo. Tendo que se adaptar cada vez mais às novas ferramentas tecnológicas, válida também na formação continuada do professor de ciências e de tecnologia, este estudante deve ser capaz de adquirir, durante o seu processo de formação, habilidades e competências de um ser autônomo e autocrítico. Tomaremos como exemplo um debate científico entre Jean de Boissoudy e Edmound Bauer sobre a teoria quântica e o calor específico dos sólidos, que possui significado histórico, embora possa ser considerado periférico para o senso comum, para quem possua pouca intimidade com a Historiografia da Ciência.
Análise das questões de Física do Exame Nacional do Ensino Médio na perspectiva da taxonomia de Bloom revisada (2014-2019)
Authors: Silva Dias Valéria , Silva Fernando Augusto , Kitamura Filho Yukio
Published: April 2022

Neste trabalho apresentamos os resultados de uma pesquisa na qual analisamos 86 itens de Física presentes nas edições de 2014 até 2019 do ENEM. Na análise utilizamos a tabela bidimensional da taxonomia de Bloom revisada, que articula a dimensão do conhecimento com a dimensão do processo cognitivo. Como principais resultados encontramos que o conhecimento do tipo conceitual foi exigido em 91,9% dos itens, enquanto o conhecimento do tipo procedimental foi demandado em 1,2% deles. Em relação a dimensão do processo cognitivo, a categoria entender foi requisitada em 36,0% dos itens e aplicar em 48,8% dos itens analisados. Os resultados indicam que, no caso de Física, o objetivo educacional priorizado no ENEM é a aprendizagem de conteúdos conceituais para aplicação na resolução de exercícios.
Ensino de física inclusivo em nível universitário: o caso do Instituto de física da UERJ
Authors: Vaz de Azevedo Ana Beatriz , De Almeida Barbosa Lima Maria da Conceição , Oliveira Ribeiro de Souza Eduardo
Published: April 2022

O presente trabalho faz parte de pesquisa realizada como conclusão do curso de licenciatura plena em Física da Universidade do Estado do Rio de Janeiro (UERJ). Este trabalho busca discutir o ensino de Física em nível universitário no atual contexto da educação inclusiva para pessoas com deficiência visual. Analisou-se um questionário que serviu de instrumento de discussão sobre a inclusão de alunos com deficiência visual a partir das respostas obtidas junto aos docentes de um Departamento de Física. Estes docentes foram questionados sobre sua formação, sua prática docente e o ensino de Física para alunos com deficiencia visual. A formação docente, ou a sua falta, mostra-se problemática para a efetiva inclusão de alunos público-alvo da educação especial em nível superior. Os docentes mostram-se pouco preparados para lidar com as diferentes especificidades de alunos. Foi verificado que a UERJ enquanto Instituição auxilia apenas ao acesso destes educandos ao ensino universitário sem mostrar incentivos a sua permanência. Os docentes não recebem nenhum tipo de apoio por parte da UERJ para que sua prática se torne realmente inclusiva. Assim, a efetiva inclusão escolar em nível universitário ainda não é uma realidade dentro do Instituto de Física desta Instituição.
Exploração de conceitos sobre a física de semicondutores através da produção de histórias em quadrinhos
Authors: Zara Reginaldo A. , Giehl Leidi Katia
Published: April 2022

Neste artigo discorremos sobre a produção de histórias em quadrinhos (HQs) pelos participantes de uma oficina didática, elaborada sob os pressupostos da estratégia de ensino dos Multimodos e Múltiplas Representações, para a abordagem do conteúdo de Semicondutores para o Ensino Médio. A oficina foi implementada em uma instituição pública de Ensino Médio do Estado do Paraná-Brasil. A atividade de produção de HQs, efetuada na parte final da oficina, permitiu aos participantes expressar suas compreensões sobre o conteúdo abordado por meio das personagens construídas e suas falas, dos cenários elaborados e enredos propostos. O acompanhamento do processo de elaboração das HQs mostrou envolvimento dos participantes com o propósito da atividade, centrada na retomada de conceitos abordados e no diálogo entre os participantes para a seleção dos itens a serem abordados nas histórias: suas personagens, cenários e enredos. Em relação ao conteúdo presente nas HQs, uma comparação entre os assuntos abordados e os conhecimentos prévios, demonstrados no início da oficina, fornecem indícios para avaliação da evolução conceitual dos participantes da oficina.
Identifikasi Bahaya, Risiko Kecelakaan Kerja Dan Usulan Perbaikan Menggunakan Metode Job Safety Analysis (JSA)
Authors: Muhammad Zulfi Ikhsan
Published: April 2022

Tamora Agro Lestari adalah perusahaan yang bergerak di bidang industri pengolahan minyak kelapa sawit. Keselamatan, dan Kesehatan Keja adalah faktor dalam menjamin kondisi pekerja saat melakukan proses pengolahan minyak kelapa sawit di PT. Tamora Agro Lestari. Observasi awal yang dilakukan menunjukkan masalah yang dihadapi oleh perusahaan ini adalah pekerja pada departemen produksi saat melakukan pekerjaannya tidak memakai APD yang lengkap sehingga meningkatkan Risiko kecelakaan kerja karena kurangnya pemahaman terkait keselamatan. Dalam memecahkan permasalahan yang dihadapi perusahaan, maka digunakan metode Job Safety Analysis (JSA) untuk mengidentifikasi bahaya, dan Risiko sehingga dapat dibuat usulan perbaikan penggunakan APD pada departemen produksi. Data terkait identifikasi proses kerja, bahaya dan Risikonya diperoleh melalui metode wawancara, dan observasi lansung. Usulan perbaikan yang dilakukan adalah mendata APD yang diperlukan sesuai dengan bahaya, dan Risiko yang teridentifikasi sebelumnya pada departemen produksi.
Implementasi Hukum Persaingan Usaha di Masa Pandemi bagi UMKM di Kota Makassar
Authors: Asmah  , Rompegading Melantik
Published: April 2022

Pandemi covid 19 membuat dunia usaha mengalami situasi tidak menentu terutama dari sektor UMKM. Berbagai upaya telah dilakukan oleh Pemerintah untuk mendukung eksistensi UMKM. Pelaksanaan hukum persaingan usaha dengan Undang-Undang Nomor 5 Tahun 1999, dan Undang- Undang Nomor 20 Tahun 2008 tentang usaha kecil dan menengah harus tetap diwujudkan, sehingga dunia usaha di Kota Makassar bisa menghasilkan kemandirian, kesejahteraan, serta menciptakan lapangan kerja.
Penelitian ini bertujuan untuk mengetahui implementasi hukum persaingan dimasa pandemi Covid-19, khususnya bagi Usaha Mikro, Kecil, dan Menengah (UMKM) di Makassar. Metode penelitian yang digunakan adalah metode penelitian normatif empiris dengan perbandingan beberapa kasus, buku, dan jurnal terkait tulisan, serta analisis tentang kasus dampak pandemi Covid-19 terhadap UMKM di kota Makassar.
Hasil penelitian menunjukan bahwa implementasi hukum persaingan usaha dimasa pandemi COVID-19 khususnya bagi UMKM Di Kota Makassar berada di bawah kontrol Komisi Pengawas Persaingan Usaha (KPPU) sebagai bentuk pengawasan terhadap kemitraan antara pelaku UMKM dan pemodal usaha besar agar terhindar dari perjanjian yang dilarang dengan menjalin kerjasama dengan dinas perdagangan dan koperasi, rutin melakukan kontrol lapangan, serta melakukan sosialisasi terhadap persaingan usaha yang sehat.
Observações Sobre o Ramo de Ouro de Frazer
Authors: Wittgenstein Ludwig
Published: April 2022

German-Portuguese en face translation of Wittgenstein's philosophical remarks on the work of the evolutionary anthropologist James Frazer.
Eficacia de sistemas expertos en la selección de granos de café (Coffea arabica)
Authors: Monsalve-Vásquez Merly
Published: April 2022

La selección de granos de café es importante para su productividad; sin embargo, productores de baja o mediana escala realizan este proceso de forma manual, ocasionado limitaciones que afectan su producción o comercialización. El artículo tuvo como objetivo analizar la eficacia de los sistemas expertos en la selección de granos de café. Para ello, el estudio consistió en una revisión sistemática de la literatura en las bases de datos de Xplore IEEE, SciencieDirect y SpringerLink, de artículos publicados en revistas indizadas a Scopus, WoS o Scielo; entre los años 2015 y 2021. El resultado de la revisión fue una matriz de información según autor, título del artículo, técnicas o modelos y eficacia de los sistemas expertos. Entre ellos, destacan el uso de los parámetros de procesamiento de imágenes RGB convertidos en HSV, como HSL; y la efectividad de los sistemas, en todos los casos fueron superiores al 80%. La revisión concluye que los sistemas expertos son eficaces para la selección de granos de café, debido a que optimizan tiempo y mejoran la calidad en la selección de granos.