bluuebunny/crossref_metadata_2025 huggingface dataset:
Neuroprotective Effect of Natural Products in Attenuation of Aging-associated Neurodegeneration
Authors: Kumar Abhai , Chaurasia Rameshwar Nath
Published: March 2023

Age-associated neurodegenerative disorders are a growing cause of mortality and morbidity in the elderly population globally. The patients suffering from neurodegenerative disorders pose medical, economic, and social issues. The agingassociated neurodegenerative disorders, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), have different clinical and neuropathological signatures, but they share a pattern of neurodegeneration in anatomical and functionally related regions. Natural products offer great potential in the prevention and therapy of neurodegenerative diseases. Plant-derived products protect neurons by targeting oxidative stress, mitochondrial dysfunction, neurotrophic factor deficit, and abnormal protein accumulation. The current chapter discusses the neuroprotective effect of natural products in the prevention of aging-associated neurodegenerative disorders.
Sesquiterpenes: A Terpene Subclass with Multifaceted Bioactivities
Authors: Di Sotto Antonella , De Paolis Federico , Gullì Marco , Vitalone Annabella , Di Giacomo Silvia
Published: March 2023

Sesquiterpenes are terpene compounds, containing three isoprene units rearranged in a wide variety of structures. They occur widely in nature, not only in plants but also in fungi and marine environments. Owing to peculiar structures and diverse biological activities, they attracted great attention in pharmaceutical, medicinal chemistry and nutraceutical fields. The present chapter collects novel insights into chemistry, distribution in nature and pharmacological properties of sesquiterpenes, focusing especially on caryophyllane, lactone-type, and eremophilane subgroups, due to the growing pharmacological interest. Novel structures and alternative natural sources to be further investigated and exploited have been highlighted too. Moreover, some issues regarding toxicity risk and bioavailability of sesquiterpenes, which can limit their application in practice, have been discussed.
Encapsulation of Essential Oils within Lipid-Based Formulations for Enhanced Antimicrobial Activity
Authors: Paolicelli Patrizia , Petralito Stefania , Trilli Jordan , Di Muzio Laura , Garzoli Stefania , Casadei Maria Antonietta
Published: March 2023

Aromatic plants have been used since ancient times for their medicinal properties, including potent antimicrobial activity. Strong evidence indicates that plant extracts, in general, and essential oils (EOs), in particular, can act as effective antimicrobial agents against a wide spectrum of pathogenic microorganisms. However, their poor water solubility and stability, as well as their high volatility, make the administration of EOs to achieve the desired therapeutic effects particularly challenging. Therefore, these features severely limit the application of EOs in the pharmaceutical field. In this context, nanotechnology-based strategies for developing nano-scaled carriers for the efficient delivery of EOs might offer potential solutions. In particular, considering the lipophilic nature of EOs, lipid-based nanocarriers represent the most suitable vehicles for the effective encapsulation and delivery of EOs. This chapter provides an overview of the different chemical compositions due to various endogenous and/or exogenous factors of a selection of oils and the most recent lipid-based encapsulation strategies to enhance their antimicrobial activity and promote their pharmaceutical application.
Koordinasi pada Pelayanan Rehabilitasi Sosial Rumah Tidak Layak Huni Kota Surabaya
Authors: Kemala Karisya Aulia Adi , Muhammad Shobaruddin
Published: March 2023

Rehabilitation of uninhabitable houses is one of the services provided by the local government to restore the function of the house by repairing parts of the house. The Social Rehabilitation Program for Uninhabitable Houses in the City of Surabaya (Rutilahu) is critical because settlements are one of the basic human needs essential in increasing human dignity and prosperous quality of life in a just and prosperous society. This study aims to explain coordination in social rehabilitation services for uninhabitable houses in Surabaya. The research method used in this research uses descriptive qualitative research. The results of this study indicate that the coordination is carried out in a bottom-up manner with the initiation of the RT/RW by collecting data on people who have suitable criteria for the beneficiaries of social rehabilitation services for uninhabitable houses in the city of Surabaya.
Selección de maracuyá
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Corporación colombiana de investigación agropecuaria, Mosquera (Colombia)
Published: March 2023

El fruto de maracuyá es catalogado como exótico por lo que este cultivo tiene un gran potencial exportador. En este clip se muestran las recomendaciones tecnológicas para la selección del fruto en el cultivo de maracuyá.
Selección y clasificación del cultivo de mora
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Corporación colombiana de investigación agropecuaria, Mosquera (Colombia)
Published: March 2023

consientes de la importancia del cultivo de mora, dado su gran potencial de oferta y demanda en el país, se muestran las siguientes recomendaciones tecnológicas para la selección y clasificación del cultivo de mora.
Regeneration of cocoa (Theobroma cacao L.) via somatic embryogenesis: Key aspects in the in vitro conversion stage and in the ex vitro adaptation of plantlets.
Authors: Henao Ramírez Ana María , Morales Muñoz Julián David , Vanegas Villa Diana Marcela , Hernández Hernández Ruth Tatiana , Urrea-Trujillo Aura Inés
Published: March 2023

Adapting plantlets to ex vitro conditions is a decisive step in the micropropagation process via organogenesis or somatic embryogenesis (ES). The percentage of success in this stage determines the quality of the product, an example of which is found in cocoa plantlets regenerated by ES, which require specific conditions to overcome the stress of the new environment. Considering the quality of the in vitro plantlets largely determines the survival and growth in ex vitro conditions, the effect of two culture media between the embryo maturation stage and the initial stage of conversion to plantlet was evaluated (EM2 - MM6 and EM2 – MF medium), achieving with the latter greater stem height, root length and the number of true leaves. In the final stage of the conversion and growth of the plantlet, the effect of five culture media was evaluated (ENR6, MF, ENR8, EDL, PR), achieving better results in stem height, root length, and the number of true leaves on MF medium. In addition, it was found that the transition of the EM2-MF had a significant development in the presence of the desired pivoting root and fibrous roots. Under nursery conditions, the growth and development of the plantlets was tested through the inoculation of beneficial microorganisms to promote survival. The plantlets that met the minimum morphological parameters for acclimation were planted in a substrate of coconut palm and sand (3:1 v/v) previously selected in the laboratory (BS). The effect of Pseudomonas ACC deaminase (PAACd), Trichoderma asperellum (Ta) and arbuscular mycorrhiza forming fungus (AMF) and different concentrations of phosphorus (PC) (0%, 50% and 100%) in the Hoagland nutrient solution (1:10) was evaluated. First, for CCN5, 62.5% of survival was obtained with PAACd + AMF. Second, the largest leaf size and survival were obtained with PAACd + Ta for CNCh12 and CCN51; likewise, for CNCh13, the best result was obtained with PAACd.

Keywords: Cacao, Clonal propagation, Mycorrhiza, Pseudomonas, Trichoderma.
Traditional agricultural knowledge of banana, cocoa and sugar cane crops as a basis for the sustainable development of the rural parish Mariscal Sucre
Authors: Lozano Sacoto Alberto Yitzak , Mendoza Haro Ítalo Edgar , Lazo Vento Carlos
Published: March 2023

The research aimed to demonstrate the impact of traditional agricultural knowledge on the sustainable development of banana, cocoa and sugar cane crops in the rural parish of Mariscal Sucre. For this, it was necessary to investigate and adopt a methodology that would estimate the degree of sustainability of the productive systems, identify how it is related to the applied practices and propose an agro-ecological management strategy for these crops. The evaluation was carried out using the MESMIS method but modified through a 30-item form applied to 61 farmers, which collected information to diagnose the incidence of agro-ecological practices and the degree of sustainability of crops. The results were processed in Excel and SPSS and presented with tables and graphs. The agricultural systems showed poor performance, falling into the category of agro-ecological unsustainability. At the same time, the most frequent customary practices consisted of the application of Mulch, and knowledge about protective and antagonistic crops.

Consequently, it was determined that there is a moderately positive correlation between agro-ecological practices and sustainability with a Spearman's Rho coefficient of 0.48; therefore, the management proposal was aimed at reinforcing the productive component with agro-ecological practices. In conclusion, the customary practices contributed to the parish's sustainable development. Therefore, it is advisable to give technical training on the implementation of integrated farms and carry out campaigns to rescue traditional agricultural knowledge.
Evaluation of hydroxymethylfurfural content in commercial and artisanal bee honey from Los Ríos-Babahoyo
Authors: Salazar Llorente Enrique José , Alvarado Álvarez Hugo Javier , Castro Cano Jamileth Marianela , Sosa Arias Byanka Margarita , Puga Lascano Sonia Alexandra
Published: March 2023

Hydroxymethylfurfural (HMF) is a compound that is produced after heat treatment of honey; that is, they are not present in the initial raw materials and can present a potential health hazard; they are known as chemical processing contaminants. This compound is an indicator parameter of the quality of honey produced spontaneously. Its concentration increases with time and other factors, such as improper heat treatment during processing, storage temperature and mode of transportation. The objective of this research is focused on evaluating the content of HMF present in 6 types of bee honey, 3 commercial brands and three artisanal brands; the honey was from eucalyptus and citrus flowering, and the place where the honey was acquired is in the Province of Los Ríos, since being a geographical area with abundant flora, the primary pollinators are bees (Apis Mellifera). In addition, the honey was heated at different temperatures and time intervals to evaluate whether Hydroxymethylfurfural increases when heat is added to the honey. The present work was carried out at the Technical University of Babahoyo; the commercial and artisanal bee honey were acquired between 1 and 5 days before the assay. For HMF analysis, a UV spectrophotometer was used, as specified in INEN 1637 standards, to determine the absorbance of the standard sample at 284 and 336 nm. The HMF values obtained for the three commercial brand honey and the artisanal brand honey are within limits allowed by INEN 1572 Technical Standard, which is 4_mg HMF/100_g of honey (40 mg HMF/kg of honey) as a maximum limit. The mean values ranged from 0.08 to 1.77 mg HMF-/g honey, while the honey subjected to heating had mean values ranging from 0.08 to 4.43 mg HMF/100_g honey. A high HMF content was determined, which exceeded the maximum limit, leading to the conclusion that commercial and artisanal honey does contain Hydroxymethylfurfural. Still, in small quantities, it is important to use good handling and preservation methods to prolong the product's shelf life.
Trampeo masivo de Plutella xylostella: una alternativa ambiental y económicamente beneficiosa para su control en Costa Rica
Authors: González-Fuentes Francisco , Niño Narváez Steven , Rodríguez-Chinchilla Carlos , Vargas-Martínez Alejandro , Gonzalez-Herrera Allan
Published: March 2023

Plutella xylostella es globalmente la plaga más importante en Brassicaceae. Desgraciadamente, su manejo sigue enfocándose en insecticidas con poco efecto sobre la plaga y con altos costos económicos y ambientales. Esta investigación buscó confirmar reportes sobre su control basado en trampeo masivo con feromona y comparar el costo de esta técnica en contraposición con la aplicación calendarizada de insecticidas. Para esto, en el año 2020, se establecieron seis parcelas experimentales en fincas comerciales de repollo en la provincia de Cartago, Costa Rica. Trampas con feromona para monitoreo se colocaron en todas las parcelas, sin embargo, solamente tres parcelas recibieron el equivalente de 50 trampas/hectárea para establecer el trampeo masivo para control de la plaga, mientras que las otras tres parcelas no tuvieron trampas adicionales a las de monitoreo y el control se basó en la aplicación calendarizada de insecticidas. Para determinar el efecto del trampeo masivo y sus costos se determinaron las capturas en trampas semanalmente durante todo el ciclo, el daño de la plaga y los costos asociados al control de la misma. Los resultados demostraron que las aplicaciones calendarizadas de insecticidas no mantuvieron poblaciones significativamente menores que el trampeo masivo. No obstante, la diferencia más evidente a favor del uso de trampeo masivo como estrategia de control se observó en el porcentaje de daño en planta y los costos involucrados, los cuales fueron significativamente menores en el trampeo masivo que en las aplicaciones de insecticidas. Los resultados obtenidos corroboran reportes sobre la capacidad ecológica y el beneficio económico de la adopción de trampeo masivo como estrategia para el control de la polilla dorso diamante.
Palabras claves. polilla dorso diamante, trampeo masivo, feromona, insecticidas, costos
Indicator framework for large-scale cacao (Theobroma cacao L.) in vitro plant production planning and controlling
Authors: Henao Ramírez Ana María , Palacio Hajduk David Hernando , Cano Martínez Diana Maria , Urrea Trujillo Aura Inés
Published: March 2023

Somatic embryogenesis (SE) is considered the most suitable and integrated biotechnology for the large-scale production of clonal cacao plants compared to conventional methods. Hence, the scale-up of relevant technologies must be interfaced with effective and efficient management of productive processes at an industrial scale like biofactories. Production facilities like biofactories serve to transform plant resources into products like plantlets. This technology constitutes an essential innovative variant since it allows obtaining high multiplication coefficients in short periods. Currently, there is no reference to carrying out adequate planning of the entire production process; for this reason, it is not used for the maximum production capacity of the facilities, and there is a high level of uncertainty. With the aid of production planning and controlling (PPC) systems, inputs can be planned to achieve a determined output of products. Therefore, this work proposes a production planning and controlling (PPC) system for SE cacao plantlet multiplication through the pilot large-scale. This paper presents input and output information considering the leading indicators of the production process, like materials, labor, quality, and performance. Emphasis is placed on technical details on the production process of 100.000 plantlets in batches from the CCN51 genotype. Through the model analysis, challenges and requirements for PPC system have been defined as a basis for future works and will have successfully managed the production process.

Keywords: Commercial-scale propagation, cost of production, indicators, somatic embryo, vegetative propagation.
Proactive and Ongoing Analysis and Management of Ethical Concerns in the Development, Evaluation, and Implementation of Smart Homes for Older Adults With Frailty
Authors: Wang Rosalie H , Tannou Thomas , Bier Nathalie , Couture Mélanie , Aubry Régis
Published: March 2023

Successful adoption and sustained use of smart home technology can support the aging in place of older adults with frailty. However, the expansion of this technology has been limited, particularly by a lack of ethical considerations surrounding its application. This can ultimately prevent older adults and members of their support ecosystems from benefiting from the technology. This paper has 2 aims in the effort to facilitate adoption and sustained use: to assert that proactive and ongoing analysis and management of ethical concerns are crucial to the successful development, evaluation, and implementation of smart homes for older adults with frailty and to present recommendations to create a framework, resources, and tools to manage ethical concerns with the collaboration of older adults; members of their support ecosystems; and the research, technical development, clinical, and industry communities. To support our assertion, we reviewed intersecting concepts from bioethics, specifically principlism and ethics of care, and from technology ethics that are salient to smart homes in the management of frailty in older adults. We focused on 6 conceptual domains that can lead to ethical tensions and of which proper analysis is essential: privacy and security, individual and relational autonomy, informed consent and supported decision-making, social inclusion and isolation, stigma and discrimination, and equity of access. To facilitate the proactive and ongoing analysis and management of ethical concerns, we recommended collaboration to develop a framework with 4 proposed elements: a set of conceptual domains as discussed in this paper, along with a tool consisting of reflective questions to guide ethical deliberation throughout the project phases; resources comprising strategies and guidance for the planning and reporting of ethical analysis throughout the project phases; training resources to support leadership, literacy, and competency in project teams for the analysis and management of ethical concerns; and training resources for older adults with frailty, their support ecosystems, and the public to support their awareness and participation in teams and ethical analysis processes. Older adults with frailty require nuanced consideration when incorporating technology into their care because of their complex health and social status and vulnerability. Smart homes may have a greater likelihood of accommodating users and their contexts with committed and comprehensive analysis, anticipation, and management of ethical concerns that reflect the unique circumstances of these users. Smart home technology may then achieve its desired individual, societal, and economic outcomes and serve as a solution to support health; well-being; and responsible, high-quality care.
Proposal of a Method for Transferring High-Quality Scientific Literature Data to Virtual Patient Cases Using Categorical Data Generated by Bernoulli-Distributed Random Values: Development and Prototypical Implementation
Authors: Schmidt Christian , Kesztyüs Dorothea , Haag Martin , Wilhelm Manfred , Kesztyüs Tibor
Published: March 2023

Background

Teaching medicine is a complex task because medical teachers are also involved in clinical practice and research and the availability of cases with rare diseases is very restricted. Automatic creation of virtual patient cases would be a great benefit, saving time and providing a wider choice of virtual patient cases for student training.

Objective

This study explored whether the medical literature provides usable quantifiable information on rare diseases. The study implemented a computerized method that simulates basic clinical patient cases utilizing probabilities of symptom occurrence for a disease.

Methods

Medical literature was searched for suitable rare diseases and the required information on the respective probabilities of specific symptoms. We developed a statistical script that delivers basic virtual patient cases with random symptom complexes generated by Bernoulli experiments, according to probabilities reported in the literature. The number of runs and thus the number of patient cases generated are arbitrary.

Results

We illustrated the function of our generator with the exemplary diagnosis “brain abscess” with the related symptoms “headache, mental status change, focal neurologic deficit, fever, seizure, nausea and vomiting, nuchal rigidity, and papilledema” and the respective probabilities from the literature. With a growing number of repetitions of the Bernoulli experiment, the relative frequencies of occurrence increasingly converged with the probabilities from the literature. For example, the relative frequency for headache after 10.000 repetitions was 0.7267 and, after rounding, equaled the mean value of the probability range of 0.73 reported in the literature. The same applied to the other symptoms.

Conclusions

The medical literature provides specific information on characteristics of rare diseases that can be transferred to probabilities. The results of our computerized method suggest that automated creation of virtual patient cases based on these probabilities is possible. With additional information provided in the literature, an extension of the generator can be implemented in further research.
Democracy in the Indonesian Digital Public Sphere: Social Network Analysis of Twitter Users' Responses to the Issue of Nationalism Knowledge Test at the Corruption Eradication Commission (TWK-KPK)
Authors: Sumartias Suwandi , Pulubuhu Dwia Aries Tina , Sudarmono Sudarmono , Noorlistyo Adi Achwan , Ratnasari Eny
Published: March 2023

The mobility restriction during the COVID-19 pandemic did not stop the public from expressing their opinions. Since they could not go on demonstrations, they moved democracy to the digital sphere, such as on Twitter. Previous research has shown that Twitter users in Indonesia use the platform to express political views and opinions on governmental issues. The issue of the Nationalism Knowledge Test (TWK) at the Corruption Eradication Commission (KPK) was a trending topic on Twitter for a while. The issue spurred discussions on Twitter when 75 employees did not pass the KPK-TWK on May 2021. The discussion then stopped for a moment before picking up again during the official dismissal of the employees on 30 September 2021. This article focuses on the social network analysis of the public’s responses to this issue on Twitter. Social network data were collected using Drone Emprit from May to October 2021 and analyzed using Gephi to generate graphical representations of the social networks. The results reveal the structure of the movement was centralized and dynamic. Regarding the dissemination of information, the most central was news media and anti-corruption activists’ accounts. These accounts mobilized the community on Twitter to make a critical social movement. This means that the digital sphere can be an evolution of democracy form and activism, especially in the anti-corruption movement.
Study the Variation of Properties of Concrete Mix Using Binding Material Portland Cement and Fly Ash Cement
Authors: Dedhia Gunjan , Dubey Aditi , Jha Abhay Kumar , Kumar Barun
Published: March 2023

bstract: In the current study, a number of experiments were carried out to compare the mechanical properties of concrete mixes made with Portland cement, fly ash cement, and their mixtures (in 1:0.5 and 1:1 proportion). A replacement silica fume of 5%, 10%, 15%, and 20% was added to concrete mixtures. The materials are combined in the ratios of 1: 1.5: 3. After three days, 14 days, and 28 days, the compressive strengths, workability, and porosity characteristics were examined. By making different types of binder mixes denser, silica fume increases their strength.
Strategi Pemasaran pada Sistem Layanan Kesehatan
Authors: Purwowiyoto Sidhi Laksono , Ananda Vilda Cattleya , Indri Priyobodo Dionisius , Raisa Cicilia Ivana
Published: March 2023

Health marketing is interdisciplinary because it uses certain concepts, methods, and techniques for classical and social marketing. The specialty of health marketing is that there are services and markets but no money equivalent. 
Healthcare marketing differs mainly by the nature of the demand for health services. The beneficiary may not be the target of a marketing campaign, and the physician decides what, where, when, and how much to provide for a particular service. To understand the impact of marketing strategies on healthcare quality, it is essential to understand today's medical consumers who prefer to seek medical information online. They also have many health services, healthcare providers, and reviews from patients who contact providers.
Estimation of the burned area with severity and its influencing factors for wildfire using Sentinel-2 satellite imagery
Authors: Sainbuyan Bayarsaikhan , Battsengel Vandansambuu , Byambakhuu Gantumur , Dashlegtseg Ganpurev , Batbayar Vandansambuu , Narantsetseg Chantsal , Altanbold Enkhbold , Byambabayar Ganbold , Nyamdavaa Batsaikhan
Published: March 2023

Wildfire is a natural disaster that harms human and animal habitats and the socio-economy. Remote sensing techniques are commonly used in the research of natural disasters, natural resources and monitoring. Timely and accurate estimation of the location of forest fires is particularly important for post-fire management and decision-making. Sentinel-2 satellite images of the European Space Agency ‘ESA’ were used to estimate the area affected by forest fires at Bayan-Uul and Bayandun soums in Dornod province, and classified the burn severity levels and comparison with other influencing factors in this study.  The normalized burn ratio ‘NBR' and indices on pre-fire and post-fire were calculated.  The total burned area was calculated as 58,131.6 ha, and low, moderate-low, moderate-high, and high burn severity levels cover 15,423.7 ha (26.3%), 29,529.4 ha (50.4%), 13,160.2 ha (22.5%), and 18.3 ha (0.03%), respectively. The 87.6% of the burned area is situated in Mongolian territory, while the remaining area (12.4%) belongs to the Russian Federation. Comparing 10 natural and geographical factors that can influence the burn severity and calculating the correlation coefficients by Pearson.  Four of them related a positive lower, and six of them related negative lower. The weak relationships of Normalized Difference Vegetation Index ‘NDVI’, elevation were 0.4 and 0.23. However, the precipitation correlation was -0.22 (negative weak). The distribution of wildfire is strongly influenced by the wind, and the correlation coefficient demonstrates a negative correlation with no effect on combustion. The conditions of socio-economic and ecological disastrous consequences such as loss of plant species and resources, changes in plant structure, depletion of pasture resources, extinction of rare animals and plants, reduction of forest resources, and large-scale air pollution resulting in the loss of human and animal in post-fire. Therefore, this research is important to due for studying the burning, distribution and, coverage area of the fire, and create conditions for the prevention of future risks.
Survival in patients with Acute Lymphoblastic Leukemia, treated with the Total XV chemotherapy protocol: A Structural Equation Model
Authors: Guerrero Enmanuel , Otzen Tamara , Monsalve Pablo , Manterola Carlos , Albarracín Lorena , Calvo Esteban
Published: March 2023

Background: Acute lymphoblastic leukemia (ALL) is the most common
neoplasm of childhood. Survival depends on a series of risk factors (RF)
that have not been jointly assessed. This study aimed to identify a
joint predictive model for disease-free survival (DFS) and overall
survival (OS) in patients with ALL treated with the Total XV
chemotherapy protocol. Methods: Retrospective cohort study of 1
to 14 years old children, treated in 2006-2020 for ALL with the Total XV
chemotherapy protocol in an Ecuadorian cancer center. Bio demographic,
clinical, immunophenotype, translocations (t), response to treatment
(RTT), DFS and OS were studied. Analyses included descriptive statistics
and predictive structural equations, using global adjustments (X
, CFI and RMSEA) and path incorporation/elimination
(Lagrange and Wald test). Results: Of the 144 children (54.9%
male) studied: 27.8% had infiltration of the Central Nervous System
(CNS); 43.1% were low risk; 4.2% presented t(9-22), and 95.8% were
immunophenotype B. Negative minimal residual disease (MRD) on days 15
and 42 of the induction phase was 43.8% and 77.1 % respectively.
Induction mortality was 9%. DFS and OS was 45% and 75.7% at 111 and
144 months, respectively. Patients with CNS infiltration, high risk and
positive MRD on days 15 and 42, had lower DFS and OS (p<0.05).
Model that included bio demographic and clinical variables, t(9-22),
immunophenotype, and RTT, obtained values that favored the proposed
model (p>0.05). Adjustment indicators corroborated the
results (CFI 0.91 and RMSEA 0.04). Conclusion: CNS infiltration,
high risk, and positive MRD are RF, which jointly explain DFS and OS in
patients with ALL treated with the Total XV chemotherapy protocol.
Forecasting Geomagnetic Storm Disturbances and Their Uncertainties using Deep Learning
Authors: Ibáñez Carlos Escobar , Villatoro Daniel Eduardo Conde , Castillo Florencia Luciana , García Carmen García , Navarro Jose Enrique García , González Verónica Sanz , Montero Bryan Zaldívar , Curto Juan José , Marsal Santiago , Torta Joan Miquel
Published: March 2023

Severe space weather produced by disturbed conditions on the Sun results
in harmful effects both for humans in space and in high-latitude
commercial flights, and for technological systems such as spacecraft or
communications. Also, geomagnetically induced currents flowing on long
ground-based conductors, such as power networks or pipelines,
potentially threaten critical infrastructures on Earth. The first step
in developing an alarm system against geomagnetically induced currents
is to forecast them. This is a challenging task, though, given the
highly non-linear dependencies of the response of the magnetosphere to
these perturbations. In the last few years, modern machine-learning
models have shown to be very good at predicting magnetic activity
indices as the SYM-H. However, such complex models are on the one hand
difficult to tune, and on the other hand they are known to bring along
potentially large prediction uncertainties which are generally difficult
to estimate. In this work we aim at predicting the SYM-H index
characterising geomagnetic storms one hour in advance, using public
interplanetary magnetic field data from the Sun–Earth L1 Lagrange point
and SYM-H. We implement a type of machine-learning model called long
short-term memory networks. Our scope is to estimate -for the first time
to our knowledge- the prediction uncertainties coming from a
deep-learning model in the context of space weather. The resulting
uncertainties turn out to be sizeable at the critical stages of the
geomagnetic storms. Our methodology includes as well an efficient
optimisation of important hyper-parameters of the long short-term memory
network and robustness tests.
Local volume solvers for Earth system data assimilation: implementation in the framework for Joint Effort for Data Assimilation Integration
Authors: Frolov Sergey , Shlyaeva Anna , Huang Wei , Sluka Travis , Draper Clara Sophie , Huang Bo , Bhargava Kriti , Whitaker Jeffrey S.
Published: March 2023

The Joint Effort for Data assimilation Integration (JEDI) is an
international collaboration aimed at developing an open software
ecosystem for model agnostic data assimilation. This paper considers
implementation of the model-agnostic family of the local volume solvers
in the JEDI framework. The implemented solvers include the Local
Ensemble Transform Kalman Filter (LETKF), the Gain form Ensemble
Transform Kalman Filter (GETKF), and the optimal interpolation variant
of the LETKF filter (LETKF-OI). This paper documents the implementation
choices and strategies that allow model agnostic implementation. We also
document an expansive set of localization approaches that includes
generic distance-based localization, localization based on modulated
ensemble products, but also localizations specific to ocean (based on
the Rossby radius of deformation), and land (based on the terrain
difference between observation and model grid point). Finally, we apply
the developed solvers in a limited set of experiments, including
single-observation experiments in atmosphere and ocean, and cycling
experiments for the ocean, land, and aerosol assimilation. We also
provide a proof of concept that illustrates how JEDI Ensemble Kalman
Filter solvers can be used in a strongly coupled framework providing
increments to the ocean based on the combined observations from the
ocean and the atmosphere.
Biases in estimating long-term recurrence intervals of extreme events due to regionalised sampling
Authors: Rafei Moutassem El , Sherwood Steven , Evans Jason Peter , Dowdy Andrew J. , Ji Fei
Published: March 2023

Preparing for environmental risks requires estimating the frequencies of
extreme events, often from data records that are too short to confirm
them directly. This requires fitting a statistical distribution to the
data. To improve precision, investigators often pool data from
neighboring sites into single samples, referred to as “superstations,”
before fitting. We demonstrate that this technique can introduce
unexpected biases in typical situations, using wind and rainfall
extremes as case studies. When the combined locations have even small
differences in the underlying statistics, the regionalization approach
gives a fit that may tend toward the highest levels suggested by any of
the individual sites. This bias may be large or small compared to the
sampling error, for realistic record lengths, depending on the
distribution of the quantity analysed. The results of this analysis
indicate that previous analyses could potentially have overestimated the
likelihood of extreme events arising from natural weather variability.
Aesthetic education and changes in the quality of life
Authors: Kopytov Alexander A. , Volkova Olga А. , Besschetnova Oksana V. , Aliev Shapi I.
Published: March 2023

Aesthetic education is an approach to teaching and learning that focuses on providing students with hands-on opportunities to inquire, question, write, and create their own artwork in order to learn about works of art. This study aims to identify the relationship between aesthetic education and improvements in patient quality of life. The study involved 120 patients of the dental department of the hospital. Analyzing individual patient records and conducting semi-structured interviews with people who have undergone aesthetic dental prosthetics were the methods used to collect data. Methods of grouping, comparative analysis, synthesis, and computer data processing were used to process the obtained data. In conclusion, people who underwent aesthetic dental prosthetics improved their quality of life, which was confirmed by objective indicators (improved nutrition, more prestigious and highly paid jobs).
Ascochyta blight (Ascochyta fabae) of faba bean (Vicia faba L.): Phenotypic and molecular characterization, pathogenicity and in vitro biological control by Bacillus spp. and Pseudomonas spp.
Authors: Oguiba Bouchra , Karkachi Noureddine , Suárez-Estrella Francisca , Haouhach Sadika , Kihal Mebrouk , López María
Published: March 2023

Ascochyta blight is a major biotic constraint of faba bean (Vicia faba L.)
production and productivity worldwide caused by Ascochyta fabae. No studies
have been performed in Algeria to identify A. fabae isolates or to assess
their pathogenicity, and therefore information on local isolates is
insufficient. Herein, 14 isolates of A. fabae were obtained from faba bean
samples and identified based on morphological traits and phylogenetic
analysis of internal transcribed spacer sequences. All generated sequences
have been deposited in GenBank and assigned accession numbers. Pathogenicity
tests on faba bean plants revealed that all isolates produced necrotic
lesions on aerial parts with variable intensity, classifying them as weakly,
moderately, and highly aggressive. The in vitro antifungal activity of
Bacillus and Pseudomonas strains against A. fabae isolates showed that
Bacillus siamensis B8 and Bacillus mojavensis B31 had the highest
suppressive potential against all isolates. Moreover, a negative correlation
was found between the aggressiveness of A. fabae isolates and their
susceptibility to biocontrol strains. This is the first report on the
identification, pathogenicity and in vitro biological control of A. fabae
isolates in Algeria. B8 and B31 could be further developed as promising
biocontrol agents for the control of the ascochyta blight of faba bean.
Scaling, dry skin and gender. A bioengineering study of dry skin
Authors: Jemec Gregor B.E. , Serup Jørgen
Published: March 2023

Dry skin and scaling was studied in a group of 72 healthy volunteers by using subjective self-assessment and by clinical assessment by a dermatologist, as well as application of noninvasive bioengineering techniques to measure scaling and epidermal hydration. The study revealed that 67% of the volunteers had subjective complaints, while only 5.6% had definite clinical signs of dry skin at the time of examination. Subjective complaints were more common in women than in men (p < 0.001), though neither clinical nor objective measurements showed any sex difference, which suggests that other factors may play a role in the way men and women perceive dry skin. Subjective and clinical scores were correlated (p < 0.02), though neither was significantly correlated to objective measurements. Grading of skin scaling on D-squame tapes correlated with densitometry of the tapes (p < 0.001), as did the electrical capacitance (p < 0.001). Both clinical and objective methods can identify dry skin. However, the study showed that in healthy persons a number of irrational factors play a role in the use of moisturizers, and while these factors cannot be measured, they must be taken into account. Healthy, but dry skin is a vaguely defined clinical entity, which may explain the generally poor correlation between the two methods. This underlines the need for several methods to be used simultaneously in order to elicit complementary information.
An epidemiological study of hand eczema.
Authors: Holm Jan-Øyvind , Veierød Marit Bragelien
Published: March 2023

No abstract available
An epidemiological study of hand eczema. IV. Degree and pattern of eczema in affected hairdressers, with and without atopic symptoms, compared with a control group of affected teachers
Authors: Holm Jan-Øyvind , Veierød Marit Bragelien
Published: March 2023

The aim of this study was to show degree and pattern of hand eczema in affected hairdressers (n = 69), compared with a control group of teachers (n = 19). Both groups consisted of employees having eczema, confirmed by the visit of a doctor at the working place. The mean age for the affected hairdressers was 27 years (range: 17-63) and for the teachers 43 years (range: 27-57). The mean duration of employment was 96 months for the hairdressers (range: 2-552) and 182 months for the teachers (range: 25-336). The localization of eczematous lesions, presence of efflorescenses and extent of skin affection were recorded by constructing scores for these variables. The mean number of localizations was significantly higher in hairdressers than in teachers; this was caused by greater affection of fingers in hairdressers compared to teachers. Seventy-five percent of the hairdressers and 79% of the teachers had only modest or very moderate erythema. Fourteen percent and 5%, respectively, had vesicular dermatitis. The right upper limb was most affected in both hairdressers and teachers. Three subgroups of hairdressers were considered: hairdressers with atopic dermatitis, those with only atopic mucosal symptoms and those without atopic symptoms. No significant differences were found between these groups, except a significant higher finger involvement in atopics compared to non-atopics.
Clinical and serological manifestations of genital human papillomavirus infection
Authors: Wikström Arne
Published: March 2023

No abstract available
Degeneration of dermal elastic fibres in relation to age and light-exposure. Preliminary report on electron microscopic studies
Authors: Danielsen L. , Kobayasi T.
Published: March 2023

No abstract available
Immunofluorescence of Tzanck smears in pemphigus vulgaris
Authors: Decherd JW. , Rubin MB. , Goldschmidt H. , Heiss HB.
Published: March 2023

No abstract available
Studies on the mechanism of action of asiaticoside (Madecassol) on experimental granulation tissue and cultured fibroblasts and its clinical application in systemic scleroderma
Authors: Sasaki S. , Shinkai H. , Akashi Y. , Kishihara Y.
Published: March 2023

No abstract available
Sensitization to chromium and cobalt in processing of sulphate pulp
Authors: Fregert S. , Gruvberger B. , Heijer A.
Published: March 2023

No abstract available
Lymphomatoid papulosis. An electron microscope study of the acute and healing stages with demonstration of paramyxovirus-like particles
Authors: Sandbank M. , Feuerman EJ.
Published: March 2023

No abstract available
Chemical binding to human dermis in vitro testosterone and benzyl alcohol
Authors: Menczel E. , Maibach HI.
Published: March 2023

No abstract available
Adenoma sebaceum in encephalofacial angiomatosis (Sturge-Weber syndrome)
Authors: Solomon LM. , Bolat IH.
Published: March 2023

No abstract available
Regeneration of the epidermis in Lyell's syndrome. A light-and electron-microscopic study
Authors: Eriksson G.
Published: March 2023

No abstract available
Effect of triphenylmethane dyes (brilliant green, crystal violet, methyl violet) on proliferation in human normal fibroblast-like and established epithelial-like cell lines
Authors: Norrby K. , Mobacken H.
Published: March 2023

No abstract available
Acne aestivalis--Mallorca acne
Authors: Hjorth N. , Sjolin KE. , Sylvest B. , Thomsen K.
Published: March 2023

No abstract available
Ultrastructural study of embryonic sebaceous cells, especially of their sebum droplet formation
Authors: Fujita H. , Asagami C. , Murota S. , Murozumi S.
Published: March 2023

No abstract available
Исследование особенностей самоотношения у девочек-подростков из полных и неполных семей
Authors: Рощина Елена
Published: March 2023

Статья посвящена исследованию особенностей самоотношения подростков женского пола из семей с разным составом. Новизна исследования обусловлена отсутствием исследований, которые рассматривали бы эту тему применительно к данному объекту. Во Введении обоснована актуальность проблемы исследования. Определены характеристики личностной и смысловой сферы детей из неполных семей, охарактеризована семья как малая группа. Рассмотрены подходы к исследованию самоотношения подростков. В данном разделе также обозначены цели и задачи исследования, приведены формулировки гипотез, предмет и объект исследования. В разделе «Методы» приведены подробные характеристики выборки, описаны методы и методики исследования. Также приведены подробные описания используемых методик: Опросник самоотношения (В. В. Столин и С. Р. Пантилеев); Тест Куна – Макпартленда «Кто Я» (Модификация Т. В. Румянцевой); Шкала самоуважения Розенберга; Анкета «Какой Я» (авторская). В разделе «Результаты» подробно изложены итоги измерения самоотношения у девочек-подростков с помощью выбранных методик. Описаны результаты статистического анализа полученных данных и их интерпретации. Обнаружено, что у девочек-подростков из полных семей количество корреляционных связей между показателями самоотношения и самоуважения больше, по сравнению с девочками-подростками из неполных семей. Это может говорить о том, что девочки-подростки из полных семей имеют более сбалансированную картину самоотношения. В разделе «Обсуждение результатов» рассмотрены позиции российских и зарубежных исследователей на тему особенностей самоотношения у подростков из полных и неполных семей. Рассмотрены связанные с семьей факторы самоотношения подростков.
Когнитивные карты личности: стандартизация метода
Authors: Тищенко Николай
Published: March 2023

В статье впервые приведены результаты апробации и стандартизации исследовательского опросника «Когнитивные карты личности». Новизна исследования заключается в создании опросника, позволяющего выявить тип когнитивной карты личности, используя математические методы, а не только качественный анализ. Во Введении представлена цель опросника, которая заключается в выявлении типа когнитивной карты личности. В данном разделе также представлено теоретическое обоснование работы. В основе опросника лежат положения о когнитивных схемах У. Найссера, Э. Толмена, Ф. Н. Шемякина. Основными типами карт выступают: карта-путь как схема взаимосвязи между объектами, опирающаяся на поэтапное разрешение актуальных ситуаций, и карта-обозрение, для которой характерны стремление к разрешению ситуаций с учетом последствий, выраженная ориентация на будущее. Методы. Для изучения типа когнитивных карт личности предложен авторский исследовательский опросник «Когнитивные карты личности», который состоит из 20 утверждений и предполагает 3 варианта ответа. Результаты. В апробации опросника принимали участие 410 респондентов. На первом этапе был рассчитан коэффициент линейной корреляции между частями опросника, изучена константность опросника. На втором этапе изучены содержательная и критериальная валидности опросника. В ходе процедуры стандартизации расчетные значения α-коэффициента Кронбаха находились в пределах 0,8-0,9, что свидетельствует о разработанности опросника, уравновешенности его частей и возможности его оценки как надежного и валидного диагностического инструмента. В процессе апробации выявлены типы когнитивных карт личности: карта-путь, карта-обозрение, неопределенный тип карты. Обсуждение результатов. Полученные результаты сравнивались с результатами аналогичных исследований типа когнитивных карт при помощи техники когнитивного картрирования. Результаты имеют высокую степень совпадения.