bluuebunny/crossref_metadata_2025 huggingface dataset:
Manufacture and Performance of Welds in Creep Strength Enhanced Ferritic Steels
Authors: Parker Jonathan , Siefert John
Published: July 2019

Welding is a vital process required in the fabrication of ‘fracture critical’ components which operate under creep conditions. However, often the procedures used are based on ‘least initial cost’. Thus, it is not surprising that in many high energy applications, welds are the weakest link, i.e., damage is first found at welds. In the worst case, weld cracks reported have had catastrophic consequences. Comprehensive Electric Power Research Institute (EPRI) research has identified and quantified the factors affecting the high temperature performance of advanced steels working under creep conditions. This knowledge has then been used to underpin recommendations for improved fabrication and control of creep strength enhanced ferritic steel components. This review paper reports background from this work. The main body of the review summarizes the evidence used to establish a ‘well engineered’ practice for the manufacture of welds in tempered martensitic steels. Many of these alternative methods can be applied in repair applications without the need for post-weld heat treatment. This seminal work thus offers major benefits to all stakeholders in the global energy sector.
Electron Donor Utilization and Secondary Mineral Formation during the Bioreduction of Lepidocrocite by Shewanella putrefaciens CN32
Authors: O’Loughlin Edward J. , Gorski Christopher A. , Flynn Theodore M. , Scherer Michelle M.
Published: July 2019

The bioreduction of Fe(III) oxides by dissimilatory iron reducing bacteria (DIRB) may result in the production of a suite of Fe(II)-bearing secondary minerals, including magnetite, siderite, vivianite, green rusts, and chukanovite; the formation of specific phases controlled by the interaction of various physiological and geochemical factors. In an effort to better understand the effects of individual electron donors on the formation of specific Fe(II)-bearing secondary minerals, we examined the effects of a series of potential electron donors on the bioreduction of lepidocrocite (γ-FeOOH) by Shewanella putrefaciens CN32. Biomineralization products were identified by X-ray diffraction, Mössbauer spectroscopy, and scanning electron microscopy. Acetate, citrate, ethanol, glucose, glutamate, glycerol, malate, and succinate were not effectively utilized for the bioreduction of lepidocrocite by S. putrefaciens CN32; however, substantial Fe(II) production was observed when formate, lactate, H2, pyruvate, serine, or N acetylglucosamine (NAG) was provided as an electron donor. Carbonate or sulfate green rust was the dominant Fe(II)-bearing secondary mineral when formate, H2, lactate, or NAG was provided, however, siderite formed with pyruvate or serine. Geochemical modeling indicated that pH and carbonate concentration are the key factors determining the prevalence of carbonate green rust verses siderite.
Role of Some Food-Grade Synthesized Flavonoids on the Control of Ochratoxin A in Aspergillus carbonarius
Authors: Ricelli Alessandra , De Angelis Martina , Primitivo Ludovica , Righi Giuliana , Sappino Carla , Antonioletti Roberto
Published: July 2019

Ochratoxin A (OTA) is a mycotoxin with a serious impact on human health. In Mediterranean countries, the black Aspergilli group, in particular Aspergillus carbonarius, causes the highest OTA contamination. Here we describe the synthesis of three polyphenolic flavonoids: 5-hydroxy-6,7-dimethoxy-flavone (MOS), 5,6-dihydroxy-7-methoxy-flavone (NEG), and 5,6 dihydroxy-flavone (DHF), as well as their effect on the prevention of OTA biosynthesis and lipoxygenase (LOX) activity in A. carbonarius cultured in a conducive liquid medium. The best control effect on OTA biosynthesis was achieved using NEG and DHF. In fungal cultures treated with these compounds at 5, 25, and 50 μg/mL, OTA biosynthesis significantly decreased throughout the 8-day experiment. NEG and DHF appear to have an inhibiting effect also on the activity of LOX, whereas MOS, which did not significantly inhibit OTA production, had no effect on LOX activity. The presence of free hydroxyls in catecholic position in the molecule appears to be a determining factor for significantly inhibiting OTA biosynthesis. However, the presence of a methoxy group in C-7 in NEG could slightly lower the molecule’s reactivity increasing OTA inhibition by this molecule at 5 μg/mL. Polyphenolic flavonoids present in edible plants may be easily synthesized and used to control OTA biosynthesis.
Zerumbone Induces Apoptosis in Breast Cancer Cells by Targeting αvβ3 Integrin upon Co-Administration with TP5-iRGD Peptide
Authors: E. M. Eid Eltayeb , S. Alanazi Abdulrahman , Koosha Sanaz , A. Alrasheedy Alian , Azam Faizul , M. Taban Ismail , Khalilullah Habibullah , Sadiq Al-Qubaisi Mothanna , A. Alshawsh Mohammed
Published: July 2019

Cell-penetrating peptides (CPPs) are highly promising tools to deliver therapeutic molecules into tumours. αVβ3 integrins are cell–matrix adhesion receptors, and are considered as an attractive target for anticancer therapies owing to their roles in the process of metastasis and angiogenesis. Therefore, this study aims to assess the effect of co-administration of zerumbone (ZER) and ZERencapsulated in hydroxypropyl-β-cyclodextrin with TP5-iRGD peptide towards cell cytotoxicity, apoptosis induction, and proliferation of normal and cancerous breast cells utilizing in vitro assays, as well as to study the molecular docking of ZER in complex with TP5-iRGD peptide. Cell viability assay findings indicated that ZER and ZERencapsulated in hydroxypropyl-β-cyclodextrin (ZER-HPβCD) inhibited the growth of estrogen receptor positivebreast cancer cells (ER+ MCF-7) at 72 h treatment with an inhibitory concentration (IC)50 of 7.51 ± 0.2 and 5.08 ± 0.2 µg/mL, respectively, and inhibited the growth of triple negative breast cancer cells (MDA-MB-231) with an IC50 of 14.96 ± 1.52 µg/mL and 12.18 ± 0.7 µg/mL, respectively. On the other hand, TP5-iRGD peptide showed no significant cytotoxicity on both cancer and normal cells. Interestingly, co-administration of TP5-iRGD peptide in MCF-7 cells reduced the IC50 of ZER from 7.51 ± 0.2 µg/mL to 3.13 ± 0.7 µg/mL and reduced the IC50 of ZER-HPβCD from 5.08 ± 0.2 µg/mL to 0.49 ± 0.004 µg/mL, indicating that the co-administration enhances the potency and increases the efficacy of ZER and ZER-HPβCD compounds. Acridine orange (AO)/propidium iodide (PI) staining under fluorescence microscopy showed evidence of early apoptosis after 72 h from the co-administration of ZER or ZER-HPβCD with TP5-iRGD peptide in MCF-7 breast cancer cells. The findings of the computational modelling experiment provide novel insights into the ZER interaction with integrin αvβ3 in the presence of TP5-iRGD, and this could explain why ZER has better antitumor activities when co-administered with TP5-iRGD peptide.
Lights Out! Nano-Scale Topography Imaging of Sample Surface in Opaque Liquid Environments with Coated Active Cantilever Probes
Authors: Xia Fangzhou , Yang Chen , Wang Yi , Youcef-Toumi Kamal , Reuter Christoph , Ivanov Tzvetan , Holz Mathias , Rangelow Ivo W.
Published: July 2019

Atomic force microscopy is a powerful topography imaging method used widely in nanoscale metrology and manipulation. A conventional Atomic Force Microscope (AFM) utilizes an optical lever system typically composed of a laser source, lenses and a four quadrant photodetector to amplify and measure the deflection of the cantilever probe. This optical method for deflection sensing limits the capability of AFM to obtaining images in transparent environments only. In addition, tapping mode imaging in liquid environments with transparent sample chamber can be difficult for laser-probe alignment due to multiple different refraction indices of materials. Spurious structure resonance can be excited from piezo actuator excitation. Photothermal actuation resolves the resonance confusion but makes optical setup more complicated. In this paper, we present the design and fabrication method of coated active scanning probes with piezoresistive deflection sensing, thermomechanical actuation and thin photoresist polymer surface coating. The newly developed probes are capable of conducting topography imaging in opaque liquids without the need of an optical system. The selected coating can withstand harsh chemical environments with high acidity (e.g., 35% sulfuric acid). The probes are operated in various opaque liquid environments with a custom designed AFM system to demonstrate the imaging performance. The development of coated active probes opens up possibilities for observing samples in their native environments.
Nutritional Deficiencies in Children with Celiac Disease Resulting from a Gluten-Free Diet: A Systematic Review
Authors: Di Nardo Giovanni , Villa Maria Pia , Conti Laura , Ranucci Giusy , Pacchiarotti Claudia , Principessa Luigi , Raucci Umberto , Parisi Pasquale
Published: July 2019

Background: A strictly gluten-free diet (GFD) is the basis for managing celiac disease (CD). Numerous studies have reported nutritional deficiencies/imbalances ascribable to a GFD. The aim of this review is to describe nutritional deficiencies observed in children with celiac disease on a GFD, to discuss the clinical consequences related to these nutritional imbalances, and to identify strategies that may be adopted to treat them. Methods: We reviewed the MEDLINE and EMBASE databases between January 1998 and January 2019. Results: Children are, regardless of whether they are on a gluten-free diet or not, at risk of consuming too much fat and insufficient fiber, iron, vitamin D, and calcium. These imbalances may be exacerbated when children are on a gluten-free diet. In particular, the intake of folate, magnesium, zinc, and foods with a high glycemic index in children with CD who are on a GFD is significantly altered. Conclusions: Therapeutic protocols should include nutritional education to help teach subjects affected by disorders such as CD the importance of labels, the choice of foods, and the combination of macro- and micronutrients. Children with CD on a GFD should be encouraged to rotate pseudo-cereals, consume gluten-free commercial products that have been fortified or enriched, and use foods that are local and naturally gluten-free.
Effectiveness of Teacher-Led Nutritional Lessons in Altering Dietary Habits and Nutritional Status in Preschool Children: Adoption of a NASA Mission X-Based Program
Authors: Kim Jieun , Kim Gilsook , Park Jinah , Wang Youfa , Lim Hyunjung
Published: July 2019

The preschool years are a sensitive period for the development of food preferences that will affect physical growth and life-long health. The promotion of healthy eating and nutritional status was achieved by adapting the US National Aeronautics and Space Administration (NASA) Mission X (MX) Program among young children in South Korea. The intervention program was delivered by nutritional experts and class teachers over 10 weeks. Children from 37 school classes (n = 534) from 7 daycares and kindergartens were randomized into a control group (CG, n = 280) and an intervention group (IG, n = 254). Parents were surveyed for their children’s characteristics and nutrition quotient (NQ) at baseline and at the 10-week follow-up. At baseline, 18.8% (boys: 18.9%; girls: 18.8%) of the subjects were overweight or obese (body mass index ≥ 85th percentile). After the intervention, the mean differences in various anthropometric measures did not differ significantly between the groups in a linear regression model adjusted for age, sex, and type of school. The NQ grades were significantly higher in the IG than the CG after the intervention (p = 0.000). In summary, the 10-week South Korean MX program improved the eating behaviors and nutrition status of young children. A further multisector prevention program is needed to prevent childhood obesity in young children.
Molecular Detection of the Seed-Borne Pathogen Colletotrichum lupini Targeting the Hyper-Variable IGS Region of the Ribosomal Cluster
Authors: Pecchia Susanna , Caggiano Benedetta , Da Lio Daniele , Cafà Giovanni , Le Floch Gaetan , Baroncelli Riccardo
Published: July 2019

Lupins anthracnose is a destructive seed and airborne disease caused by Colletotrichum lupini, affecting stems and pods. Primary seed infections as low as 0.01–0.1% can cause very severe yield losses. One of the most effective management strategies is the development of a robust and sensitive seed detection assay to screen seed lots before planting. PCR-based detection systems exhibit higher levels of sensitivity than conventional techniques, but when applied to seed tests they require the extraction of PCR-quality DNA from target organisms in backgrounds of saprophytic organisms and inhibitory seed-derived compounds. To overcome these limitations, a new detection protocol for C. lupini based on a biological enrichment step followed by a PCR assay was developed. Several enrichment protocols were compared with Yeast Malt Broth amended with ampicillin, streptomycin, and lactic acid were the most efficient. A species-specific C. lupini primer pair was developed based on rDNA IGS sequences. The specificity was evaluated against 17 strains of C. lupini, 23 different Colletotrichum species, and 21 different organisms isolated from seeds of Lupinus albus cv. Multitalia, L. luteus cv. Mister, and L. angustifolius cv. Tango. The protocol described here enabled the detection of C. lupini in samples artificially infected with less than 1/10,000 infected seed.
Facile Fabrication of Durable Superhydrophobic Films from Carbon Nanotube/Main-Chain Type Polybenzoxazine Composites
Authors: Wang Chih-Feng , Wang Wen-Ning , Lin Ching-Hsuan , Lee Kuo-Jung , Hu Chien-Chieh , Lai Juin-Yih
Published: July 2019

Superhydrophobic materials have immense applications in the fields of industry and research. However, their durability is still a cause for concern. A facile method for preparing durable superhydrophobic films from carbon nanotubes (CNTs) and the main-chain type polybenzoxazine precursors is reported herein. We used probe ultrasonicator to prepare CNT/polybenzoxazine coatings. Compared with the general sonicating dispersion process, the dispersion time was greatly reduced from a few hours to 5 minutes and the prepared suspension exhibited film-forming characteristics well. The CNT/polybenzoxazine films, which do not contain any fluorinated compounds, exhibit remarkable durability against thermal treatment, organic solvents, corrosive liquids, and sandpaper abrasion, while retaining their superhydrophobicity. Furthermore, these CNT/polybenzoxazine films also showed durable superhydrophobicity after ultraviolet (UV) irradiation for 100 h. This CNT/polybenzoxazine film can be readily used for practical applications to make durable superhydrophobic coatings.
High-Level Conversion of l-lysine into Cadaverine by Escherichia coli Whole Cell Biocatalyst Expressing Hafnia alvei l-lysine Decarboxylase
Authors: Kim Hee Taek , Baritugo Kei-Anne , Oh Young Hoon , Kang Kyoung-Hee , Jung Ye Jean , Jang Seyoung , Song Bong Keun , Kim Il-Kwon , Lee Myung Ock , Hwang Yong Taek , Park Kyungmoon , Park Si Jae , Joo Jeong Chan
Published: July 2019

Cadaverine is a C5 diamine monomer used for the production of bio-based polyamide 510. Cadaverine is produced by the decarboxylation of l-lysine using a lysine decarboxylase (LDC). In this study, we developed recombinant Escherichia coli strains for the expression of LDC from Hafnia alvei. The resulting recombinant XBHaLDC strain was used as a whole cell biocatalyst for the high-level bioconversion of l-lysine into cadaverine without the supplementation of isopropyl β-d-1-thiogalactopyranoside (IPTG) for the induction of protein expression and pyridoxal phosphate (PLP), a key cofactor for an LDC reaction. The comparison of results from enzyme characterization of E. coli and H. alvei LDC revealed that H. alvei LDC exhibited greater bioconversion ability than E. coli LDC due to higher levels of protein expression in all cellular fractions and a higher specific activity at 37 °C (1825 U/mg protein > 1003 U/mg protein). The recombinant XBHaLDC and XBEcLDC strains were constructed for the high-level production of cadaverine. Recombinant XBHaLDC produced a 1.3-fold higher titer of cadaverine (6.1 g/L) than the XBEcLDC strain (4.8 g/L) from 10 g/L of l-lysine. Furthermore, XBHaLDC, concentrated to an optical density (OD600) of 50, efficiently produced 136 g/L of cadaverine from 200 g/L of l-lysine (97% molar yield) via an IPTG- and PLP-free whole cell bioconversion reaction. Cadaverine synthesized via a whole cell biocatalyst reaction using XBHaLDC was purified to polymer grade, and purified cadaverine was successfully used for the synthesis of polyamide 510. In conclusion, an IPTG- and PLP-free whole cell bioconversion process of l-lysine into cadaverine, using recombinant XBHaLDC, was successfully utilized for the production of bio-based polyamide 510, which has physical and thermal properties similar to polyamide 510 synthesized from chemical-grade cadaverine.
Online Decision-Support Tool “TECHoice” for the Equipment Technology Choice in Sterile Filling Processes of Biopharmaceuticals
Authors: Shirahata Haruku , Badr Sara , Shinno Yuki , Hagimori Shuta , Sugiyama Hirokazu
Published: July 2019

In biopharmaceutical manufacturing, a new single-use technology using disposable equipment is available for reducing the work of change-over operations compared to conventional multi-use technology that use stainless steel equipment. The choice of equipment technologies has been researched and evaluation models have been developed, however, software that can extend model exposure to reach industrial users is yet to be developed. In this work, we develop and demonstrate a prototype of an online decision-support tool for the multi-objective evaluation of equipment technologies in sterile filling of biopharmaceutical manufacturing processes. Multi-objective evaluation models of equipment technologies and equipment technology alternative generation algorithms are implemented in the tool to support users in choosing their preferred technology according to their input of specific production scenarios. The use of the tool for analysis and decision-support was demonstrated using four production scenarios in drug product manufacturing. The online feature of the tool allows users easy access within academic and industrial settings to explore different production scenarios especially at early design phases. The tool allows users to investigate the certainty of the decision by providing a sensitivity analysis function. Further enrichment of the functionalities and enhancement of the user interface could be implemented in future developments.
Raison d’état, Religion, and the Body in The Rape of Lucrece
Authors: Mohamed Feisal G.
Published: July 2019

With an emphasis on the religious figuration of its heroine’s chaste body, the present essay explores the political dynamics of The Rape of Lucrece. The poem draws on Roman religion and Christianity: Lucrece is an emblem of purity, with echoes of the flaminica or Vestal virgins, and her spotlessness anticipates Christ’s. Seeing these qualities allows us to engage the poem’s gender dynamics and its politics, with both of these being centered on issues of property. While The Rape of Lucrece has been enlisted as an artifact of late Elizabethan republican culture, its depiction of the expulsion of the Tarquins need not lead us to that conclusion. It is nonetheless a product of the political anxieties of Elizabeth’s final years.
FludoJelly: Experimental Study on Jellyfish-Like Soft Robot Enabled by Soft Pneumatic Composite (SPC)
Authors: Joshi Aniket , Kulkarni Adwait , Tadesse Yonas
Published: July 2019

Several bio-inspired underwater robots have been demonstrated in the last few years that can horizontally swim using different smart actuators. However, very few works have been presented on robots which can swim vertically, have a payload and resemble a jellyfish-like creature. In this work, we present the design, fabrication, and performance characterization of a new tethered robotic jellyfish, which is based on inflatable soft pneumatic composite (SPC) actuators. These soft actuators use compressed air to expand and contract, which help the robot to swim vertically in water. The soft actuators consist of elastomeric air chambers and very thin steel springs, which contribute to gaining faster motion of the biomimetic robot. A prototype of 220 mm in diameter and consisting of eight actuating units was fabricated and tested underwater in a fish tank. It reached a height of 400 mm within 2.5 s while carrying a dead weight of 100 g when tested at 70 psi (483 kPa) pressure. This high performance (160 mm/s on average speed) suggests that faster motion with a payload can be achieved by using SPC actuators. The inflatable structures help to flap the bell segments as well as in buoyancy effect for rapid vertical motion. The major achievement of this work is the ability to demonstrate a novel use of inflatable structures and biomimetic flapping wings for fast motion in water. The experimental and deduced data from this work can be used for the design of future small unmanned underwater vehicles (UUVs). This work adds a new robot to the design space of biomimetic jellyfish-like soft robots. Such kind of vehicle design might also be useful for transporting objects underwater effectively.
Water-Quality Classification of Inland Lakes Using Landsat8 Images by Convolutional Neural Networks
Authors: Pu Fangling , Ding Chujiang , Chao Zeyi , Yu Yue , Xu Xin
Published: July 2019

Water-quality monitoring of inland lakes is essential for freshwater-resource protection. In situ water-quality measurements and ratings are accurate but high costs limit their usage. Water-quality monitoring using remote sensing has shown to be cost-effective. However, the nonoptically active parameters that mainly determine water-quality levels in China are difficult to estimate because of their weak optical characteristics and lack of explicit correlation between remote-sensing images and parameters. To address the problems, a convolutional neural network (CNN) with hierarchical structure was designed to represent the relationship between Landsat8 images and in situ water-quality levels. A transfer-learning strategy in the CNN model was introduced to deal with the lack of in situ measurement data. After the CNN model was trained by spatially and temporally matched Landsat8 images and in situ water-quality data that were collected from official websites, the surface quality of the whole water body could be classified. We tested the CNN model at the Erhai and Chaohu lakes in China, respectively. The experiment results demonstrate that the CNN model outperformed widely used machine-learning methods. The trained model at Erhai Lake can be used for the water-quality classification of Chaohu Lake. The introduced CNN model and the water-quality classification method could cover the whole lake with low costs. The proposed method has potential in inland-lake monitoring.
Electrochemical Nanocomposite Single-Use Sensor for Dopamine Detection
Authors: Selvolini Giulia , Lazzarini Cinzia , Marrazza Giovanna
Published: July 2019

In this work, we report the development of a simple and sensitive sensor based on graphite screen-printed electrodes (GSPEs) modified by a nanocomposite film for dopamine (DA) detection. The sensor was realized by electrodepositing polyaniline (PANI) and gold nanoparticles (AuNPs) onto the graphite working electrode. The sensor surface was fully characterized by means of the cyclic voltammetry (CV) technique using [Fe(CN)6]4−/3− and [Ru(NH3)6]2+/3+ as redox probes. The electrochemical behavior of the nanocomposite sensor towards DA oxidation was assessed by differential pulse voltammetry (DPV) in phosphate buffer saline at physiological pH. The sensor response was found to be linearly related to DA concentration in the range 1–100 μM DA, with a limit of detection of 0.86 μM. The performance of the sensor in terms of reproducibility and selectivity was also studied. Finally, the sensor was successfully applied for a preliminary DA determination in human serum samples.
On the Accuracy of Factory-Calibrated Low-Cost Soil Water Content Sensors
Authors: Domínguez-Niño Jesús María , Bogena Heye Reemt , Huisman Johan Alexander , Schilling Bernd , Casadesús Jaume
Published: July 2019

Soil water content (SWC) monitoring is often used to optimize agricultural irrigation. Commonly, capacitance sensors are used for this task. However, the factory calibrations have been often criticized for their limited accuracy. The aim of this paper is to test the degree of improvement of various sensor- and soil-specific calibration options compared to factory calibrations by taking the 10HS sensor as an example. To this end, a two-step sensor calibration was carried out. In the first step, the sensor response was related to dielectric permittivity using calibration in media with well-defined permittivity. The second step involved the establishment of a site-specific relationship between permittivity and soil water content using undisturbed soil samples and time domain reflectometry (TDR) measurements. Our results showed that a model, which considered the mean porosity and a fitted dielectric permittivity of the solid phase for each soil and depth, provided the best fit between bulk permittivity and SWC. Most importantly, it was found that the two-step calibration approach (RMSE: 1.03 vol.%) provided more accurate SWC estimates compared to the factory calibration (RMSE: 5.33 vol.%). Finally, we used these calibrations on data from drip-irrigated almond and apple orchards and compared the factory calibration with our two-step calibration approach.
Deep Multi-Layer Perception Based Terrain Classification for Planetary Exploration Rovers
Authors: Bai Chengchao , Guo Jifeng , Guo Linli , Song Junlin
Published: July 2019

Accurate classification and identification of the detected terrain is the basis for the long-distance patrol mission of the planetary rover. But terrain measurement based on vision and radar is subject to conditions such as light changes and dust storms. In this paper, under the premise of not increasing the sensor load of the existing rover, a terrain classification and recognition method based on vibration is proposed. Firstly, the time-frequency domain transformation of vibration information is realized by fast Fourier transform (FFT), and the characteristic representation of vibration information is given. Secondly, a deep neural network based on multi-layer perception is designed to realize classification of different terrains. Finally, combined with the Jackal unmanned vehicle platform, the XQ unmanned vehicle platform, and the vibration sensor, the terrain classification comparison test based on five different terrains was completed. The results show that the proposed algorithm has higher classification accuracy, and different platforms and running speeds have certain influence on the terrain classification at the same time, which provides support for subsequent practical applications.
The Concept of Family Farming in the Portuguese Political Discourse
Authors: Dinis Isabel
Published: July 2019

Although several countries have outlined national and multi-criteria definitions, family farming is not well defined in most countries including Portugal, making it difficult to assess its real importance as well as the reasons underlying the design and the success/failure of particular policies. The main purpose of this study is to investigate the framing of family farming in the Portuguese political discourse by applying content analysis to a range of national policies and planning documents. The results show little reference to family farming in political documents and a conceptualization of family farming made in antagonism to professional or entrepreneurial farmers.
Applying an RRI Filter in Key Learning on Urban Living Labs’ Performance
Authors: Van Geenhuizen Marina
Published: July 2019

Urban living labs is a practical methodology in improving sustainability in cities by facilitating collaborative learning and innovation in a real-life environment, thereby mainly responding to the needs of users (citizens). The paper aims to filter a list of key learnings on urban living labs through the lens of Responsible Research and Innovation (RRI). One of the motivations is that key learnings on urban living labs are mainly derived from means-goal effectiveness (MGE) thinking while the urban setting calls for a broader perspective due to complexity and tension from the multi-actor, multifunctional, and multi-scalar character of cities. The filtering reveals almost 40 learnings as ‘overlap’ and ‘exclusive for MGE’. Importantly, five learnings are identified as specific for RRI and potentially enriching living lab methodology: ethical and normative principles like health, safety, security, and equality between societal groups, and a wider distribution of benefits and risks of living lab outcomes, in particular, contradictory sustainability issues. The RRI filtering causes three practical implications: coping with uneven power distribution between stakeholders, limited feasibility of applying the comprehensive learning framework, and challenges of overarching platform structures enabling to better incorporate RRI concerns in living lab methodology. The findings as presented in an adapted list are new, as RRI values and concerns have seldom been applied to practical innovation and have never been explicitly applied to urban living labs’ performance beyond the borders of effectiveness thinking.
A Comparative Analysis of Fuzzy TOPSIS and Geographic Information Systems (GIS) for the Location Selection of Shopping Malls: A Case Study from Turkey
Authors: Erdin Ceren , Akbaş Halil Emre
Published: July 2019

Multi-criteria decision-making (MCDM) techniques are increasingly being used for the problem of location selection, which directly affects the long-term success of a company. Besides these techniques, with the advantage of handling both spatial and non-spatial data, geographic information systems (GIS) also represent a useful method for selecting the appropriate location for different kinds of facilities and sites. In this respect, this study aims to compare the results of a MCDM technique, fuzzy technique for order preference by similarity to ideal solution (TOPSIS), and GIS for the location selection of shopping malls in Turkey. According to the results of both fuzzy TOPSIS and GIS, the Marmara region was determined as the best alternative for shopping malls in Turkey.
A Stochastic Simulation Model for the Optimization of the Taxi Management System
Authors: Król Aleksander , Król Małgorzata
Published: July 2019

The paper presents a simplified simulation model of the operation of a taxi system. The model retains the main features of a real taxi transportation system and despite its simplicity examines the system behavior in different conditions. It was shown that for every request generation rate a critical number of taxis in disposal could be determined. If the real number of taxis is lower than the critical number, the queue of pending requests grows in an unlimited way. On the other hand, if the real number of taxis is significantly higher, the service level is clearly not better and leads to the waste of taxi drivers’ time and fuel. The presented model can be regarded as a queue system; therefore, the well-known queue theory is used to describe its nature. However, this approach has some practical limitations coming from incomplete knowledge on real transportation demands, which additionally undergo significant fluctuations. A method, which optimizes the assignment of vacant taxis to the pending requests was also introduced. It was proven that this method mitigated the influence of the above-mentioned limitations.
Intellectual Capital, Profitability, and Productivity: Evidence from Pakistani Financial Institutions
Authors: Yao Hongxing , Haris Muhammad , Tariq Gulzara , Javaid Hafiz Mustansar , Khan Muhammad Aamir Shafique
Published: July 2019

The idiosyncratic and knowledge-intense nature of the financial institutions requires them to rely more on intangible than on tangible resources. Over the past two decades, researchers have been motivated to embark on the relationship between intellectual capital (IC) and performance of financial institutions. Considering the knowledge-based intellect as a critical skill of this era, the current study examines the impact of IC on the performance of 111 Pakistani financial institutions (PFIs) over the period 2007–2018. Two IC measures, i.e., value-added intellectual coefficient (VAIC) and modified value-added intellectual coefficient (MVAIC), were applied to examine the impact of IC on profitability and productivity. Robust results from the fixed effect regression and generalized method of momentum affirm the inverted U-shaped relationship between IC and performance, suggesting that the increase in IC performance of PFIs increases their profitability and productivity up to a certain level, and after that, a further increase in IC performance decreases profitability and productivity. The results further suggest that human capital is the most influencing intellectual resource which produces higher intellectual efficiencies and increases the performance significantly. The results of this study are likely to be helpful for management, regulators, policy makers, and academics and provide insights into the importance of IC and suggest that the investment in the IC improves the sustainable performance to a certain extent.
Environmental Sustainability: A Review of Termite Mound Soil Material and Its Bacteria
Authors: Enagbonma Ben , Babalola Olubukola
Published: July 2019

The high quantity of nutrients accumulated in termite mound soils have placed termite mound as a ‘gold mine’ for bacteria concentrations. However, over the years, not much attention has been given to the bacteria present in termite mound soil. This is because many studies have focused on approaches to manage termites which they see as menace to agricultural crops and buildings. Therefore, we aimed to evaluate the potential application of termite mound soil material and its bacteria for biotechnological purposes. This review has been grouped into four key parts: The termite mound as hotspot for bacterial concentration, the degradation of lignocellulose for biofuel production, termite mound soil as a soil amendment, and the role of termite mound soil and its bacteria in bioremediation and bio-filtration. Therefore, the effective usage of the termite mound soil material and its bacteria in an ecofriendly manner could ensure environmental sustainability.
Maxwell Electrodynamics in Terms of Physical Potentials
Authors: Majumdar Parthasarathi , Ray Anarya
Published: July 2019

A fully relativistically covariant and manifestly gauge-invariant formulation of classical Maxwell electrodynamics is presented, purely in terms of gauge-invariant potentials without entailing any gauge fixing. We show that the inhomogeneous equations satisfied by the physical scalar and vector potentials (originally discovered by Maxwell) have the same symmetry as the isometry of Minkowski spacetime, thereby reproducing Einstein’s incipient approach leading to his discovery of special relativity as a spacetime symmetry. To arrive at this conclusion, we show how the Maxwell equations for the potentials follow from stationary electromagnetism by replacing the Laplacian operator with the d’Alembertian operator, while making all variables dependent on space and time. We also establish consistency of these equations by deriving them from the standard Maxwell equations for the field strengths, showing that there is a unique projection operator which projects onto the physical potentials. Properties of the physical potentials are elaborated through their iterative Nöther coupling to a charged scalar field leading to the Abelian Higgs model, and through a sketch of the Aharonov–Bohm effect, where dependence of the Aharonov–Bohm phase on the physical vector potential is highlighted.
Methods for the Identification of Outliers and Their Influence on Exposure Assessment in Agricultural Pesticide Applicators: A Proposed Approach and Validation Using Biological Monitoring
Authors: Mandić-Rajčević Stefan , Colosio Claudio
Published: July 2019

The “patch” approach for skin exposure assessment can easily be combined with biological monitoring in real-life pesticide studies. Nevertheless, this approach is sensitive to outliers, with values markedly deviating from other members of the sample, which can result in a gross overestimation of exposure. This study aimed at developing methods for outlier identification and validating them while using biological monitoring. Twenty-seven workers applying mancozeb in Italian vineyards participated in this study. Their skin exposure was estimated while using the patch methodology, while ethylene-thiourea (ETU) was measured in the 24-h post-exposure urine as a biomarker of exposure. The outliers were detected using methods that were based on the multiplication of the median, the median absolute deviation, and boxplots. The detection rate varied between 2.3% and 17.3%. The estimated median skin exposure of 3.2 μg was reduced to 1.2 μg when the modified Z score was used. The highest reduction in the skin exposure was above 54 μg. The use of the modified Z score for outlier detection resulted in an increase in the correlation coefficient between the skin exposure and the urine ETU levels from 0.46 to 0.71, which suggested the validity of the approach. Future studies should standardize and improve the methods for pesticide exposure and risk assessment.
Dynamical Properties of the Mukhanov-Sasaki Hamiltonian in the Context of Adiabatic Vacua and the Lewis-Riesenfeld Invariant
Authors: Fahn Max Joseph , Giesel Kristina , Kobler Michael
Published: July 2019

We use the method of the Lewis-Riesenfeld invariant to analyze the dynamical properties of the Mukhanov-Sasaki Hamiltonian and, following this approach, investigate whether we can obtain possible candidates for initial states in the context of inflation considering a quasi-de Sitter spacetime. Our main interest lies in the question of to which extent these already well-established methods at the classical and quantum level for finitely many degrees of freedom can be generalized to field theory. As our results show, a straightforward generalization does in general not lead to a unitary operator on Fock space that implements the corresponding time-dependent canonical transformation associated with the Lewis-Riesenfeld invariant. The action of this operator can be rewritten as a time-dependent Bogoliubov transformation, where we also compare our results to already existing ones in the literature. We show that its generalization to Fock space has to be chosen appropriately in order to not violate the Shale-Stinespring condition. Furthermore, our analysis relates the Ermakov differential equation that plays the role of an auxiliary equation, whose solution is necessary to construct the Lewis-Riesenfeld invariant, as well as the corresponding time-dependent canonical transformation, to the defining differential equation for adiabatic vacua. Therefore, a given solution of the Ermakov equation directly yields a full solution of the differential equation for adiabatic vacua involving no truncation at some adiabatic order. As a consequence, we can interpret our result obtained here as a kind of non-squeezed Bunch-Davies mode, where the term non-squeezed refers to a possible residual squeezing that can be involved in the unitary operator for certain choices of the Bogoliubov map.
Vesicular Stomatitis Virus-Based Vaccines Provide Cross-Protection against Andes and Sin Nombre Viruses
Authors: Warner Bryce M , Stein Derek R , Jangra Rohit K , Slough Megan M , Sroga Patrycja , Sloan Angela , Frost Kathy L , Booth Stephanie , Chandran Kartik , Safronetz David
Published: July 2019

Andes virus (ANDV) and Sin Nombre virus (SNV) are the main causative agents responsible for hantavirus cardiopulmonary syndrome (HCPS) in the Americas. HCPS is a severe respiratory disease with a high fatality rate for which there are no approved therapeutics or vaccines available. Some vaccine approaches for HCPS have been tested in preclinical models, but none have been tested in infectious models in regard to their ability to protect against multiple species of HCPS-causing viruses. Here, we utilize recombinant vesicular stomatitis virus-based (VSV) vaccines for Andes virus (ANDV) and Sin Nombre virus (SNV) and assess their ability to provide cross-protection in infectious challenge models. We show that, while both rVSVΔG/ANDVGPC and rVSVΔG/SNVGPC display attenuated growth as compared to wild type VSV, each vaccine is able to induce a cross-reactive antibody response. Both vaccines protected against both homologous and heterologous challenge with ANDV and SNV and prevented HCPS in a lethal ANDV challenge model. This study provides evidence that the development of a single vaccine against HCPS-causing hantaviruses could provide protection against multiple agents.
A Case Study: Response Mechanics of Irregular Rotational Tidal Flows to Outlet Regulation in Yangtze Estuary
Authors: Hu Dechao , Wang Min , Yao Shiming , Jin Zhongwu
Published: July 2019

Responses of irregular rotational tidal flows to an outlet regulation (the Guyuan Sand (GYS) regulation) in the three-level branching Yangtze Estuary are studied by a high-resolution numerical model and theoretical analysis. The project is launched around GYS at the outlet of the North Branch of the Yangtze Estuary. The tidal flows around GYS are rotational and become irregular under the influences of the runoff-tide interactions, rapidly varying topographies and complex solid boundaries in coastal areas. Three designs of GYS regulation were studied, including various diversion dikes and new outlets of different widths. The regulation disturbs the irregular rotational flows around GYS, and further changes the estuarine tidal processes and the water exchange between different branches of the branching Yangtze Estuary. It was interesting to find that additional current and additional storage are formed along the North Branch when a southward outlet and the clockwise rotational flow met around GYS. This special phenomenon is named “guide effect” in this study. The guide effect, together with common resist effect (arising from the narrowed outlet channel), reshapes the estuarine tidal processes. Based on the simulation result and a theoretical analysis, response mechanics of irregular rotational tidal flows to the outlet regulation in complex branching estuaries are quantitatively studied.
Increased Dependence on Irrigated Crop Production Across the CONUS (1945–2015)
Authors: Smidt Samuel , Kendall Anthony , Hyndman David
Published: July 2019

Efficient irrigation technologies, which seem to promise reduced production costs and water consumption in heavily irrigated areas, may instead be driving increased irrigation use in areas that were not traditionally irrigated. As a result, the total dependence on supplemental irrigation for crop production and revenue is steadily increasing across the contiguous United States. Quantifying this dependence has been hampered by a lack of comprehensive irrigated and dryland yield and harvested area data outside of major irrigated regions, despite the importance and long history of irrigation applications in agriculture. This study used a linear regression model to disaggregate lumped agricultural statistics and estimate average irrigated and dryland yields at the state level for five major row crops: corn, cotton, hay, soybeans, and wheat. For 1945–2015, we quantified crop production, irrigation enhancement revenue, and irrigated and dryland areas in both intensively irrigated and marginally-dependent states, where both irrigated and dryland farming practices are implemented. In 2015, we found that irrigating just the five commodity crops enhanced revenue by ~$7 billion across all states with irrigation. In states with both irrigated and dryland practices, 23% of total produced area relied on irrigation, resulting in 7% more production than from dryland practices. There was a clear response to increasing biofuel demand, with the addition of more than 3.6 million ha of irrigated corn and soybeans in the last decade in marginally-dependent states. Since 1945, we estimate that yield enhancement due to irrigation has resulted in over $465 billion in increased revenue across the contiguous United States (CONUS). Example applications of this dataset include estimating historical water use, evaluating the effects of environmental policies, developing new resource management strategies, economic risk analyses, and developing tools for farmer decision making.
Evaluation of the GPM IMERG v5 and TRMM 3B42 v7 Precipitation Products in the Yangtze River Basin, China
Authors: Wu Yifan , Zhang Zengxin , Huang Yuhan , Jin Qiu , Chen Xi , Chang Juan
Published: July 2019

The purpose of this study is to quantitatively evaluate the accuracy of the GPM IMERG v5 and the TRMM 3B42 v7, with the reference of 224 rain gauge stations over the Yangtze River basin in China from April 2014 to December 2017. The results showed that: (1) The changing pattern of IMERG v5 was similar to the 3B42 v7, and higher correlations can be found between the satellite-based precipitation products (SPPs) and observed precipitation for the monthly and annual time scale; (2) the IMERG v5 tended to overestimate the distribution range of the main rain band while the 3B42 v7 underestimated the precipitation in Sichuan basin, and the largest differences were found for the precipitation less than 1 mm/d for two SPPs; (3) both of the IMERG v5 and 3B42 v7 overestimated the precipitation in the lower elevation areas (<3000 m), while the opposite was true for areas ≥ 3000 m (RBIMERG v5 = −5.42%, RB3B42 v7 = −1.87%), and the retrieved results of PPDFc index and average precipitation at different altitudes for IMERG v5 were better than 3B42 v7. This study highlighted that IMERG v5 performed generally better than 3B42 v7 in detecting precipitation, especially light precipitation in the Yangtze River basin, indicating the great potential utility in hydrological applications. However, its poor skills when retrieving data for high precipitation events and for detecting complex terrain environments remains, leaving room for IMERG v5 to improve its inversion algorithm.
Spatial–Temporal Matching Characteristics between Agricultural Water and Land Resources in Ningxia, Northwest China
Authors: Du Jie , Yang Zhaohui , Wang Hao , Yang Guiyu , Li Shuoyang
Published: July 2019

Agricultural water and land resources are key elements of human production and their unbalanced distribution has threatened the sustainable development of agriculture and regional food security. This study is aiming to investigate the spatial–temporal changes of matching characteristics between agricultural water and land resources in Ningxia during 2007 to 2017. The agricultural irrigation water (AIW), farmland area (FA) and effective irrigated area (EIA) were selected as quantity parameters for agricultural water and land resource. Results show that the gravity centers of AIW and EIA both moved in the southeast direction, while the gravity center of FA moved northwestward, which indicated a better spatial matching degree between AIW and EIA. According to the Gini coefficient and total spatial mismatch index, the spatial mismatch between AIW and FA of Ningxia was remedied and that of AIW and EIA was worse. Counties with sufficient and insufficient AIW were distributed in the north and the south of Ningxia, respectively. The sensitivity of agricultural irrigation water to land resources remarkably increased in the study period, particularly for the counties in northern area of Ningxia. The findings may provide implications for effective management of regional agricultural water and land resources.