bluuebunny/crossref_metadata_2025 huggingface dataset:
Treatment Patterns for Metastatic Urothelial Carcinoma Across Eight Mexican Centers: The ALEBRIJE Study
Authors: Beas-Lozano Evelyn Lilian , Remolina-Bonilla Yuly A. , Caballero Rosa , Sobrevilla-Moreno Nora , Perez-Perez Perla , Díaz-Alvarado Maria Guadalupe , Zayas-Villanueva Omar Alejandro , Martinez-Castañeda Erika Adriana , Campos-Gomez Saul , Cardoso-Aparicio Luis Arturo , Mendoza-Oliva Dolores , Bourlon Maria T.
Published: January 2025

PURPOSE

Metastatic urothelial carcinoma (mUC) poses a challenge to health care systems, given its treatment complexity and mortality. We aimed to describe the characteristics, treatment patterns, and survival outcomes of Mexican patients with mUC.

METHODS

A retrospective study was conducted across eight centers for adults with mUC from January /2001 to December 2021. We recorded medical history, eligibility for first-line platinum therapy, treatment lines received, and access to novel drugs. Descriptive statistics were used and survival analysis, including Kaplan-Meier curves and Cox proportional hazards model, was performed.

RESULTS

We identified 379 patients with mUC; 37 were excluded, and 76% was male, with a median age of 67 years. The median follow-up was 8.4 months. Among those who received a first-line treatment (65%), cisplatin-based chemotherapy (45%) was the most common followed by carboplatin (39%). Causes of cisplatin ineligibility were Eastern Cooperative Oncology Group ≥2 (41%) and glomerular filtration rate <60 mL/min (33%). The overall response rate to up-front platinum therapy was 33%, with a median progression-free survival of 6.1 months (95% CI, 4.9 to 6.9). Second-, third-, and fourth-line treatment was given to 24.6%, 8.8%, and 3.5%, respectively. Chemotherapy was the most common regimen prescribed. Access to novel drugs was limited, 14 patients received avelumab, and 25% received immunotherapy as second-line treatment. The median overall survival was 11.8 months (95% CI, 10.2 to 15.2). Multivariate analysis showed that first-line treatment was independently associated with better survival, whereas poor performance status and visceral disease were associated with worse survival.

CONCLUSION

To our knowledge, these data represent the first effort to delineate treatment trends of mUC in Mexico. First-line treatment prescription and rates of progression to platinum therapy were higher than those described worldwide. Factors affecting survival included performance status, first-line treatment, and visceral disease. Our study highlights unequal access to novel treatments, underscoring the need for equitable care.
Metronomic Capecitabine Plus Aromatase Inhibitor as Initial Therapy in Patients With Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer—The Phase III MECCA Trial
Authors: Hong Ruo-Xi , Xu Fei , Xia Wen , Teng Yue-E , Ouyang Qu-Chang , Zheng Qiu-Fan , Yuan Zhong-Yu , Chen Dong-Shao , Jiang Kui-Kui , Lin Ying , Dai Zhen , Liu Xin-Lan , Chen Qian-Jun , Wu Xin-Hong , Shi Yan-Xia , Huang Jia-Jia , An Xin , Xue Cong , Bi Xi-Wen , Chen Mei-Ting , Li Hui , Yao He-Rui , Zou Guo-Rong , Huang Heng , Zhang Jing-Min , Wang Shu-Sen
Published: January 2025

PURPOSE

The effects of metronomic chemotherapy plus endocrine therapy have yet to be elucidated through a randomized phase III clinical trial.

METHODS

Randomized clinical trials were conducted at 12 centers in China from August 22, 2017, to September 24, 2021, and the final follow-up date was August 25, 2023. Patients with hormone receptor–positive, human epidermal growth factor receptor 2 (HER2)–negative metastatic breast cancer (MBC) who had no previous systemic therapy in the metastatic setting were enrolled. Participants were 1:1 assigned to receive either metronomic capecitabine plus an aromatase inhibitor (AI) or AI alone. The primary end point was progression-free survival (PFS). Secondary end points included overall survival (OS), objective response rate, disease control rate (defined as disease controlled for ≥24 weeks), and safety.

RESULTS

A total of 263 patients were randomly assigned, among which 254 patients formed the full analysis set. At the median follow-up time of 50.7 months, 203 PFS events occurred. The metronomic capecitabine plus AI arm exhibited a median PFS of 20.9 months compared with 11.9 months in the AI arm (hazard ratio [HR], 0.58 [95% CI, 0.43 to 0.76]). The median OS was not reached in the combination arm and was 45.1 months in the AI arm (HR, 0.58 [95% CI, 0.37 to 0.93]). The most common adverse events were palmar-plantar erythrodysesthesia and peripheral neuropathy; grade 3 events occurred in 15.1% of the patients receiving combination treatment.

CONCLUSION

The MECCA trial demonstrated a significant improvement in PFS and OS with first-line metronomic capecitabine plus AI compared with AI alone in patients with hormone receptor-positive+/HER2-negative MBC. Both treatment arms exhibited tolerable safety profiles consistent with previous reports.
Correlated catalyst in quantum thermodynamics
Authors: Shiraishi Naoto
Published: January 2025

In this short review article, we present recent progress in quantum thermodynamics in the framework with a correlated catalyst. We examine two key properties of thermal operations, the Gibbs-preserving property and the covariant property. The state convertibility of a Gibbs-preserving operation is fully characterized by the second law of thermodynamics with the nonequilibrium free energy. The state convertibility of a covariant operation is shown to be free as long as an initial state has finite coherence. We finally show that these two findings can be combined in the enhanced thermal operation (covariant Gibbs-preserving operation).
Cushing Disease Clinical Phenotype and Tumor Behavior Vary With Age: Diagnostic and Perioperative Implications
Authors: Salcedo-Sifuentes Jorge Eduardo , Shih Ryan , Heaney Anthony P , Bergsneider Marvin , Wang Marilene B , Donangelo Ines , Lee Jivianne , Delery William , Karsy Michael , Kshettry Varun R , Yuen Kevin C J , Evans James J , Barkhoudarian Garni , Pacione Donato R , Gardner Paul A , Fernandez-Miranda Juan C , Benjamin Carolina , Zada Gabriel , Rennert Robert C , Silverstein Julie M , Chicoine Michael R , Kim Jiyoon , Li Gang , Little Andrew S , Kim Won
Published: January 2025

Context

Little is known about presenting clinical characteristics, tumor biology, and surgical morbidity of Cushing disease (CD) with aging.

Objective

Using a large multi-institutional data set, we assessed diagnostic and prognostic significance of age in CD through differences in presentation, laboratory results, tumor characteristics, and postoperative outcomes.

Methods

Data from the Registry of Adenomas of the Pituitary and Related Disorders (RAPID) were reviewed for patients with CD treated with transsphenoidal tumor resection at 11 centers between 2003 and 2023. Outcomes assessed included comorbidities, presenting features, preoperative endocrine evaluations, perioperative characteristics, postoperative endocrine laboratory values, and complications.

Results

Of the 608 patients evaluated, 496 (81.6%) were female; median age at surgery was 44 years (range, 10-78 years). Increasing age was associated with increasing comorbidities, frailty, rates of postoperative thromboembolic disease, Knosp grade, tumor size, and postoperative cortisol and adrenocorticotropin nadirs. Conversely, increasing age was associated with decreased hallmark CD features, preoperative 24-hour urinary free cortisol, Ki-67 indices, and arginine vasopressin deficiency. Younger patients presented more frequently with weight gain, facial rounding/plethora, abdominal striae, hirsutism, menstrual irregularities, dorsocervical fat pad, and acne. Obstructive sleep apnea and infections were more common with increasing age.

Conclusion

There are age-dependent differences in clinical presentation, tumor behavior, and postoperative outcomes in patients with CD. Compared to younger patients, older patients present with a less classic phenotype characterized by fewer hallmark features, more medical comorbidities, and larger tumors. Notably, age-related differences suggest a more indolent tumor behavior in older patients, potentially contributing to delayed diagnosis and increased perioperative risk. These findings underscore the need for tailored diagnostic and therapeutic approaches across age groups, with a focus on managing long-term comorbidities and optimizing surgical outcomes.
Positive autoregulation of Sox17 is necessary for gallbladder and extrahepatic bile duct formation
Authors: Trinh Linh T. , Finnel Ryan R. , Osipovich Anna B. , Musselman Jessica R. , Sampson Leesa L. , Wright Christopher V. E. , Magnuson Mark A.
Published: January 2025

Expression of SRY-box transcription factor 17 (Sox17) in the endodermal region caudal to the hepatic diverticulum during late gastrulation is necessary for hepato-pancreato-biliary system formation. Analysis of an allelic series of promoter-proximal mutations near the transcription start site (TSS) 2 of Sox17 in mouse has revealed that gallbladder (GB) and extrahepatic bile duct (EHBD) development is exquisitely sensitive to Sox17 expression levels. Deletion of a SOX17-binding cis-regulatory element in the TSS2 promoter impairs GB and EHBD development by reducing outgrowth of the nascent biliary bud. These findings reveal the existence of a SOX17-dependent autoregulatory loop that drives Sox17 expression above a critical threshold concentration necessary for GB and EHBD development to occur, and that minor impairments in Sox17 gene expression are sufficient to impair the expression of SOX17-regulated genes in the nascent GB and EHBD system, impairing or preventing development.
Abnormal H3K27me3 underlies degenerative spermatogonial stem cells in cryptorchid testis
Authors: Kuroha Kazushige , Dočkal Ivana , Radović Uroš , Nakajima Kuniko , Hoshi Ikue , Matsuda Shion , Kojitani Noriko , Ohbo Kazuyuki , Tomizawa Shin-ichi
Published: January 2025

Cryptorchidism is the most frequent congenital defect in newborn males characterized by the absence of the testis from the scrotum. Approximately 90% of individuals with untreated bilateral cryptorchidism exhibit azoospermia due to defective spermatogenesis in the affected testis. Although abnormal spermatogonial stem cell maintenance or differentiation is suggested to cause germ cell degeneration in the cryptorchid testis, the underlying molecular mechanisms remain unclear. Here, we profiled spermatogonial epigenetic landscapes using surgically induced cryptorchid testis in the mouse. We show that cryptorchidism leads to alterations in local, but not global, H3K27me3 and H3K9me3 in undifferentiated spermatogonia. Of these, the loss of H3K27me3 was correlated with activation of developmental and proapoptotic pathway genes that are repressed by the polycomb machinery in germ cells. Cryptorchid spermatogonia exhibit an increase of the H3K27me3 demethylases KDM6A and KMD6B. Furthermore, we reveal that an increased temperature leads to Kdm6a/b upregulation in germline stem cells cultured in vitro. Thus, our study suggests that temperature-dependent histone demethylation may induce mRNA dysregulation due to the partial loss of H3K27me3 in spermatogonia.
The transformative qualities and potential of cinematherapy: Using film art in the training of educators in intercultural education
Authors: Roumpou Christina , Magos Kostas
Published: January 2025

This article highlights the transformative qualities and potential of cinematherapy, which make it an appropriate and innovative pedagogical tool. The relevant literature review shows that with regard to cinematherapy in education ¾both adult and minor¾ international research is limited. Relative research in Greece is non-existent. The aim of the paper is to present the method developed in the framework of an original experiential training programme for educators for the development of intercultural competence through films and cinematherapy, entitled "CINEducation". The programme is theoretically framed by critical pedagogy, the principles of intercultural and inclusive education, as well as adult education, in particular transformative learning and person-centred education. The programme is also linked to the principles of experiential learning, education through art and action research, placing the focus on individual and subjective experience, otherness and the transformative potential of education and cinematherapy. It aims to contribute to the fields of intercultural and film education, responding to the growing demand for training educators with new tools and in new tools. Film and cinematherapy are used as a means of personal and professional development through the gradual, intervening, non-directive discovery of knowledge and development of skills and attitudes that promote the principles of intercultural education.
Διερεύνηση της επίδρασης της ποιότητας της σχέσης με τον εκπαιδευτικό και των εφαρμοζόμενων διδακτικών πρακτικών στην συναισθηματική ευεξία μαθητών πρωτοσχολικής ηλικίας
Authors: Γαλούση Βασιλική , Καρέλα Χριστίνα
Published: January 2025

Tο σχολικό περιβάλλον μπορεί να συμβάλει στην προαγωγή της ψυχοκοινωνικής ανάπτυξης και της ανθεκτικότητας των μαθητών παρέχοντάς τους τα κατάλληλα εφόδια. Μεταξύ των παραγόντων που φαίνεται να έχουν σημαντικό αντίκτυπο στην συναισθηματική και ακαδημαϊκή ανάπτυξη των παιδιών περιλαμβάνονται η ποιότητα της σχέσης εκπαιδευτικού-μαθητή, η παροχή υποστήριξης, οι θετικές/ ρεαλιστικές προσδοκίες, το θετικό κλίμα μάθησης αλλά και οι διδακτικές πρακτικές που υιοθετούνται. Η παρούσα εργασία αποσκοπεί στη διερεύνηση της συναισθηματικής ευεξίας μαθητών των πρώτων τάξεων του Δημοτικού σχολείου (6- 8 ετών), σύμφωνα με ορισμένους δηλωτικούς ενδοατομικούς και περιβαλλοντικούς προστατευτικούς παράγοντες (π.χ. προσοχή, αυτοέλεγχος, πρωτοβουλία, φιλοκοινωνική συμπεριφορά, συνεργασία σχολείου-οικογένειας) καθώς και των πιθανών διαφορών της ως προς το φύλο και τη σχολική επίδοση. Επιπλέον, μελετήθηκε η σύνδεση της ποιότητας της σχέσης εκπαιδευτικών-μαθητών καθώς και των διδακτικών πρακτικών που εφαρμόζονται στην τάξη με τη συναισθηματική ευεξία των μαθητών. Συμμετείχαν 160 εκπαιδευτικοί από την Αττική, αλλά και την υπόλοιπη Ελλάδα απαντώντας στο ερωτηματολόγιο της έρευνας αναφορικά με τους/τις μαθητές/τριες τους. Τα αποτελέσματα ανέδειξαν σημαντικές διαφορές της ευεξίας ως προς το φύλο και τη σχολική επίδοση των παιδιών, με τα κορίτσια και τους μαθητές με υψηλή επίδοση να παρουσιάζουν υψηλότερα επίπεδα συναισθηματικής ευεξίας. Επιπρόσθετα, βρέθηκε ότι οι σχέσεις εγγύτητας μεταξύ εκπαιδευτικών-μαθητών καθώς και οι διδακτικές πρακτικές προσανατολισμένες στη μάθηση σχετίζονται θετικά με τους παράγοντες συναισθηματικής ευεξίας, ενώ αντίστροφα οι συγκρουσιακές σχέσεις και οι διδακτικές πρακτικές προσανατολισμένες στην επίδοση σχετίζονταν αρνητικά. Η συγκεκριμένη εργασία αποσκοπεί να συνεισφέρει στην ενίσχυση του έργου των εκπαιδευτικών και στη διαμόρφωση θετικής εκπαιδευτικής πολιτικής, ιδίως σε παιδιά πρώιμης σχολικής ηλικίας.
Καλλιεργώντας την ιδιότητα του πολίτη μέσα από το μάθημα των καλλιτεχνικών στην Πρωτοβάθμια και Δευτεροβάθμια εκπαίδευση: Εμπειρίες, εκτιμήσεις και απόψεις εκπαιδευτικών
Authors: Πλαστήρα Ρόζα
Published: January 2025

Η καλλιτεχνική εκπαίδευση διαμορφώνει ολόπλευρα τους μαθητές, συμβάλλοντας στη γνωστική, συναισθηματική και πνευματική τους ανάπτυξη. Ωστόσο, σε ένα συνεχώς μεταβαλλόμενο κόσμο, αναδεικνύεται η ανάγκη να καλλιεργηθούν και ως ενεργοί πολίτες. Καθοριστικός σε αυτή τη διαδικασία είναι ο ρόλος του εκπαιδευτικού, ως διαμεσολαβητή μεταξύ μαθητών και πολιτισμικού περιβάλλοντος. Σκοπός της παρούσας έρευνας, ήταν να διερευνηθούν οι αντιλήψεις των εκπαιδευτικών καλλιτεχνικών μαθημάτων πρωτοβάθμιας και δευτεροβάθμιας εκπαίδευσης, αναφορικά με το ρόλο τους, τις δυνατότητες διαμόρφωσης της ιδιότητας του πολίτη μέσα από το μάθημά τους, τις γνώσεις και δεξιότητες που θεωρούν απαραίτητες για την καλλιέργεια της πολιτειότητας, τις μεθόδους και πρακτικές που υιοθετούν προς αυτή την κατεύθυνση, και τις δυσκολίες που αντιμετωπίζουν. Υιοθετήθηκε η ποιοτική μέθοδος έρευνας, μέσω της διεξαγωγής δέκα ημι-δομημένων συνεντεύξεων. Τα ευρήματα έδειξαν ότι για την πολιτική κοινωνικοποίηση των μαθητών, δεν παίζουν καθοριστικό ρόλο οι γνώσεις και δεξιότητες των εκπαιδευτικών, αλλά η σχετική ευαισθητοποίησή τους. Επίσης, φάνηκε ότι παρόλο που οι εκπαιδευτικοί επιδιώκουν την καλλιέργεια δεξιοτήτων άμεσα συνυφασμένων με την πολιτειότητα, η επιλογή τους αποτελεί απόρροια της αντίληψης που έχουν για το ρόλο της καλλιτεχνικής εκπαίδευσης και όχι συνειδητή προσπάθεια διαμόρφωσης των μαθητών ως πολιτών. Υπογραμμίζεται έτσι η ανάγκη εστιασμένων επιμορφώσεων, προκειμένου οι εκπαιδευτικοί καλλιτεχνικών μαθημάτων να προάγουν αποτελεσματικότερα την πολιτειότητα.
The influence of digital marketing on cultural consumption. Case studies from Greece and Germany
Authors: Tsavdaridou Despoina , Papadaki Eirini
Published: January 2025

This cross-national research examines the digital communication strategy of four cultural organizations in Greece and Germany and attempts to study the influence of digital marketing on cultural consumption. In order to include both visual and performing arts in the research dataset, the authors examined two performing arts organizations and two visual arts museums: the National Opera and the National Gallery-Museum of Alexandros Soutsos for Greece and the Old Opera Frankfurt and the Pinakotheken for Germany.The methodology includes both qualitative and quantitative tools. Content analysis of websites and social media posts, as well as interviews were conducted, aiming at highlighting good practices as well as points that need improvement. A comparative quantitative audience survey was conducted through two digital questionnaires, one for each country. According to the results of the qualitative and quantitative data, it becomes clear that digital marketing through websites and social media is the key in the hands of experts for optimal two-way communication with their audience, while the more they listen to the needs and desires of the audience the closer they will be to fully unleashing the power of digital marketing as an interactive, community-building mechanism.
Lean, Green & Digital and the need for cross-functional collaboration – Requirements when heading from Industry 4.0 towards Industry 5.0
Authors: Tsipoulanidis Alexander
Published: January 2025

Supply chains are becoming significantly vulnerable. Furthermore, governmental regulations demand and the customers expect, that the products are made under best sustainable, ecological and social conditions. Competition is high, which leads to the challenge to create products fast, efficiently and under best ecological conditions. This all can be summarized as the high demand for Lean, Green and Digital processes in value creation that is discussed in this qualitative paper.
The purpose of this paper is to qualitatively explore how state-of-the-art management thinking in combination with digital solutions can help companies to be successful nowadays. It is expected, that cross-functional collaboration is essential to compete at these turbulent times. Efficiency and short response times to meet legal requirements as well as to create products under the paradigm of circular economy are key drivers for success. Additionally the technological and digital advancements need to be considered at the same time. Three fundamental aspects are not covered by Industry 4.0 so far, which are: i) the role of the human being during value creation, ii) SC resilience and iii) focus on sustainability. These elements are leading to the central theme of this paper and will be discussed in the following sections
Acute Kidney Injury Complicating Critical Forms of COVID-19: risk Factors and Prognostic Impact
Authors: Guissouma Jihene , Ben Ali Hana , Allouche Hend , Trabelsi Insaf , Hammami Olfa , Yahia Yosra , Hatem Ghadhoune
Published: January 2025

Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) mainly affects the respiratory tract, but different organs may be involved including the kidney. Data on acute kidney injury (AKI) in critical forms of coronavirus disease 2019 (COVID-19) are scarce. We aimed to assess the incidence, risk factors and prognostic impact of AKI complicating critical forms of COVID-19. Methods A retrospective descriptive case/control monocentric study conducted in a medical intensive care unit of a tertiary teaching hospital over a period of 18 months. Results We enrolled 144 patients, with a mean age of 58±13 years old and a male predominance (sex-ratio: 1.25). Forty-one (28%) developed AKI within a median of 4 days (Q1: 3, Q3: 8.5) after hospitalization. It was staged KDIGO class 3, in about half of the cases. Thirteen patients underwent renal replacement therapy and renal function improved in seven cases. Diabetes (OR: 6.07; 95% CI: (1,30-28,4); p: 0.022), nephrotoxic antibiotics (OR: 21; 95% CI: (3,2-146); p: 0.002), and shock (OR: 12.21; 95% CI: (2.87-51.85); p: 0.031,) were the three independent risk factors of AKI onset. Mortality was significantly higher in AKI group (HR:12; 95% CI: (5.81-18.18); p:0.041) but AKI didn’t appear to be an independent risk factor of poor outcome. In fact, age > 53 years (p: 0.018), septic shock complicating hospital acquired infection (p: 0.003) and mechanical ventilation (p<0.001) were the three prognostic factors in multivariate analysis. Conclusions The incidence of AKI was high in this study and associated to an increased mortality. Diabetes, use of nephrotoxic antibiotics and shock contributed significantly to its occurrence. This underlines the importance of rationalizing antibiotic prescription and providing adequate management of patients with hemodynamic instability in order to prevent consequent AKI.
Hästitempereeritud eelmäng. Kirg ja vaoshoitus seksuaalsuhetes varauusaegses Euroopas
Authors: Laur Mati
Published: January 2025

Abstract: A Well-Tempered Foreplay. Passion and Constraint in Sexual Relations in Early Modern Europe
The church prescribed norms for sexual behaviour, stipulating four requirements for sexual intercourse: it had to take place within marriage, it had to be genital (ruling out anal and oral intercourse), it had to be heterosexual, and with some concessions it also had to be procreative – aimed at conceiving children. The Reformation admittedly did away with marriage as a sacrament, but that did not mean that Protestants depreciated marriage as an institution. Compared to their Catholic counterparts, Protestant theologians placed considerably greater emphasis on the importance of sexual ties between a married man and woman. Marriage was no longer a conceded form of cohabitation, but rather one that was preferred and recommended. Luther not only stipulated the requirement to marry, but also the duty of marriage, which required sexual activity from both the man and the woman. Along with this requirement, sexual life was forced into a marital framework even more. Leaving the duties of marriage (debitum conjugale) unfulfilled was deplored in both theological and medical literature and it was acceptable grounds for divorcing marriage.
The church’s requirement to exercise sexual restraint in marriage contradicted the medical understandings of that time. According to the teachings of Hippocrates and Galen of Pergamon that were current in the early modern era, both men and women had semen – women’s semen was situated in the womb, which opened up when the woman became sexually aroused. Conception took place when male semen was mixed with female semen. This in turn required that both the man and the woman achieved orgasm. If the woman hated her husband, then the womb would not open up and conception would not take place. From the medical viewpoint of that time, in order for the woman to conceive, the sexual stimulation of the woman was not only permissible, but altogether indispensable. Hence two almost contradictory opinions concerning the encouragement of sexual intercourse took shape: the medical – the more, the better – and the theological – the less, the better. While physicians gave spouses advice on how to conceive children as effectively as possible, theologians taught how to behave as sinlessly as possible.
The Enlightenment redefined the sexuality of women. By the end of the 18th century, the knowledge that the woman’s orgasm or its absence was of no importance whatsoever regarding conception gained general acceptance. From that point onward, the woman’s part in the sexual sphere was relegated to a passive role that implied indifference and dispassion during coitus. Bourgeois marriage, which started to take shape at the end of the early modern era, altered conceptions that had hitherto been current. While pleasure had been a sin before the Enlightenment era, thereafter pleasure became irrational and foolish.
The influence of the sinonasal microbiome on the development and management of rhinosinusitis
Authors: Lang Miriam , Bereza Dawid , Kulak-Waśniewska Maria , Moreau Igor , Polańska Paulina , Sokołowska Katarzyna , Woch Barbara
Published: January 2025

Introduction and purpose: Chronic rhinosinusitis (CRS) is a frequently diagnosed condition in patients seeking medical care. It encompasses a range of disorders that can be classified based on underlying causes, clinical symptoms, or inflammatory types. Although the precise cause of CRS remains unclear, the European Position Paper on Rhinosinusitis and Nasal Polyps 2020 (EPOS 2020) has recently offered updated insights, treatment strategies, and recommendations.
State of knowledge: Recent research has increasingly focused on the role of the microbiota in inflammatory diseases. The optimal bacterial environment in the sinonasal mucosa, where inhaled bacteria, viruses, fungal spores, and particles initially interact, is still not fully understood. The dysbiosis theory, which emphasizes the importance of the microbiome and its relationship with the host, is the predominant model explaining CRS pathogenesis. Disruptions in this balance can lead to a variety of clinical manifestations in CRS patients.
Conclusions: Given the impact of CRS treatment on the composition of sinus and nasopharyngeal microbiota, the dysbiosis theory highlights the importance of addressing this aspect in therapeutic strategies. Ongoing research is exploring the potential use of pre- and probiotics as novel treatment options. A more thorough understanding of the microbiological factors involved in CRS is crucial for developing personalized, targeted therapies for affected individuals.
Ground state solutions for a critical fractional Laplacian equation in unbounded domains: existence and regularity
Authors: Shen Yansheng
Published: January 2025

In this work we study the following fractional critical problem
\begin{align*}
\begin{cases}
(-\Delta)^{s}u=\lambda|u|^{q-2}u+|u|^{2_{s}^{\ast}-2}u
& \mbox{in } \Omega, \\
u=0 & \text{in }\mathbb{R}^{N}\setminus \Omega,
\end{cases}
\end{align*}
where $\Omega$ is an open unbounded strip-like domain in $\mathbb{R}^{N}$, $N> 2s$ with $s\in(0,1)$, $\lambda> 0$, $q\in[2,2_{s}^{\ast})$ and $2_{s}^{\ast}=2N/(N-2s)$.
By variational methods, we prove the existence of positive ground state solutions to the problem. Further, we study the regularity of these solutions.
Precisely, using a Brézis-Kato type estimate for unbounded domains,
we establish the $L^{\infty}$-bound on nonnegative solutions of the equation for certain range of $q$. The present work extends the existence and regularity results for fractional Laplace equations to unbounded domains.
Design an Automatic Water Tank Filling Tool Using NodeMCU Based on the Internet of Things
Authors: Hazbi Taufan Maulana , Ma'arif Alfian
Published: January 2025

Drought is still common in Indonesia, especially in the prolonged dry season while the world's clean water reserves are only around 3%. Groundwater is a renewable natural resource, but overexploitation can cause problems such as sink holes, land subsidence, and seawater intrusion, therefore, the design of filling water tanks and automatic height meters is made as an effort to save water.  these automatic water tank measurements use the Internet of Things method accessed through Blynk. An internet of things-based tool measurement system with a water level principle uses an ultrasonic HC-SR04 sensor to measure Blynk's integrated water level, using the Nodemcu ESP8266 microcontroller as the main control. The overall result of the design of the tool, the water topping up process is shown in units of percent, the ultrasonic sensor HC-SR04 displays the actual distance and water level to Blynk in cm.
Techno – Economic Analysis of Rooftop Solar Panel Uprating on Commercial Building (Casestudy on Karawang Branch Office of XYZ Company)
Authors: Widyanto Aji Nur , Adhi Muhamad Arya Krisna , Husnayain Faiz , Utomo Agus R , Ardita I Made
Published: January 2025

On April 22nd, 2016, Indonesia signed the Paris Agreement, which goal is that the world will enter the net-zero emission phase in 2060. To support that, it is better to increase the solar rooftop capacity have been installed. In this study, there are some variations, such as the capacity of solar rooftops based on load profile and installed power (75%, 90%, and 100%), variation of solar module placement, and variation of solar module types. The result shows that to fulfill the load needs, it will need 40 kW of inverter capacity and 49.5 kWp of PV capacity with a total module of 113 pcs. Based on the solar module type simulations result, the 440 Wp B – brand has the highest performance result among the others. Uprating solar rooftop capacity will cost around Rp.1,138,529,870 for the investment, and the payback period is around 18 years. This study finds that uprating the capacity of rooftop solar panel can reduce electricity tariffs and increase energy production. Moreover, the results of the economic analysis revealed that the initial cost, interest rate, and electricity price will play crucial roles in determining whether to launch a project or not.
An Overview of Artificial Intelligence (AI) in 6G: Types, Advantages, Challenges and Recent Applications
Authors: Al-Ansi Abdullah M. , Al-Ansi Ahmed
Published: January 2025

The world is on the cusp of a new communications revolution. The next generation of communication networks, known as 6G, will enable a wide range of new applications and services that are not possible with current 4G or 5G networks. In overview, we will review Artificial Intelligence (AI) Types, Advantages, challenges and some of the most promising applications of 6G technology. Some of the key applications that are being developed for 6G communication networks include Digital Twin (DT), Holograms, Robot Avatar, High Density (IoT), and AR & VR. The use of these applications in 6G communication networks is not a new concept, but integration to 6G will need more improvements. These applications have been around for some time now and have seen various improvements over the years. However, with the advent of 6G communication networks, the use of AR and VR is expected to see a drastic change. This paper contributes to the existing literature about the nature of 6G and applications to give more understanding and further discussion in potential and new trends.
Monitoring Temperature and Humidity of Boiler Chicken Cages Based on Internet of Things (IoT)
Authors: Sanjaya Dhimas Dwiki , Fadlil Abdul
Published: January 2025

Animal husbandry is a business sector that is growing rapidly. Poultry is very popular with the community, especially broiler chickens. However, breeders find it difficult to maintain the condition of broiler chickens because these poultry are heat stress birds that are easily stressed if the coop conditions are too hot or cold. Because of this, this research was conducted to design a system that can control the temperature and humidity values of the chicken coop automatically. The system designed in this study uses a DHT11 sensor which is useful for detecting the temperature and humidity values of the chicken coop. The microcontroller used is NodeMCU. The temperature and humidity values are sent via IoT (Internet of Things) to the ThingSpeak media platform. The fan will turn on if the temperature value is more than 31° C. The mist maker will light up if the humidity value is less than 55%, and the incandescent lamp will light up if the temperature value is less than 29° C. The system testing performed resulted in a temperature error value of 1,05% and humidity error value of 2,39%. The system's ability to turn on fans, mist makers, and incandescent lamps when the temperature value does not match the conditions can also run well.
Naive Bayes Method Monitoring Macro Nutrition and Soil Moisture Using Naive Bayes Method based on Internet of Things
Authors: Rahadian Herwindo , Yudhana Anton
Published: January 2025

The different land quality causes farmers not to know the exact quality of their agricultural land. Improper processing of agricultural land can result in a decrease in the quality of a land. The content of soil macronutrients consists of nitrogen (N), phospor (P), and potassium (K), these contents that usually affect plant growth. The development of an optical transducer for which is used to measure the wavelength of an object in everyday life can use led sensors as a light source and photo diodes as light detection using the TCRT5000 sensor as an infrared wave transmitter module. The use of the internet of things at this time is very useful to facilitate monitoring. The use of naïve bayes to determine the resulting probability. the soil moisture content obtained averaged 20.63% and nitrogen content values with an average of 590, Phospor 513 and Potassium 670. The sending of data to ThingSpeak can be determined as desired. It is hoped that this research can be developed by refining the use of sensors and methods used to make it easier to apply in life.
Sentiment Analysis of Electronic System Provider (PSE) Method Using Support Vector Machine
Authors: Turiyan Turiyan , Saputra Nurirwan , Riyadi Ahmad , Tentua Meilany Nonsi
Published: January 2025

The study discusses the policy issued by the Indonesian Ministry of Communication and Information on Electronic System Providers (PSE), with a special emphasis on the impact of the policy that has triggered public reactions on social media platforms. Based on the regulations that have been made, it has an impact on the public who believe that the regulation is made to take away access freedom and data privacy on digital systems used by the public. Sentiment analysis can see public opinion on the policy issued by the Ministry of Communication and Information. The data used is taken from social media which is labeled "positive" and "negative". The research method used in sentiment analysis is the Support Vector Machine method. The contribution of this research is to determine the boundary line between the two classes in this research data. The result of the F1 score can be measured in the model, with a achieved value of 75%.
Industrial Relations Dispute Simulation System Prototype with Artificial Intelligence Approach
Authors: Parmenas Naik Henokh , Samosir Ridha Sefina
Published: January 2025

There are many cases of industrial relations disputes/IRD every year. IRD cases can be resolved by kinship or mediation to reduce the material burden of all parties, such as case costs other than time and energy. With this background, the researcher proposed developing a system for simulating the IRD judicial process with an AI approach. AI encourages faster and high-accuracy prediction results because AI works through the learning process against a set of training data to produce learning models. The research method used is an experimental laboratory to select AI algorithms with the highest accuracy. Meanwhile, for system development methods, research proposes prototyping methods with designing systems using UML. Prototyping is an option because it takes the intensity of communication between the developer and the end user to determine the prototype of the system being built. System development with platform website. UML provides a variety of diagrams that facilitate communication with developers to illustrate the system being built. System testing uses the black box methodology approach because at this stage, testing is carried out to ensure that the functional system has met the needs. From the experimental results, the decision tree algorithm provides the highest accuracy of 80% in training and testing a set of datasets in the form of cases and IRD court rulings from 2022. The accuracy score means that the learning model by the decision tree algorithm can correctly predict (TP / True positive) 75 % of all cases (test data). The accuracy score is obtained through a confusion matrix that shows the performance of the decision tree algorithm for classification. The results of this research help the process of simulating IRD cases before being taken to judicial line to minimize costs and other efforts that could potentially be incurred during judicial process.
Quadrotor Altitude Control using Recurrent Neural Network PID
Authors: Rahani Faisal Fajri , Rosyady Phisca Aditya
Published: January 2025

The quadrotor is one type of Unmanned Aerial Vehicle (UAV) or unmanned flying vehicle. Quadrotor can be operated by a remote controller or autonomously. Quadrotor control is a challenging problem because it takes into account complex things such as parametric uncertainty, external disturbances, and so on. At the spatial level, three linear degrees of freedom along three axes and three degrees of freedom rotating along three axes are used for the control of a quadrotor. Conventional controls for quadrotors are widely used such as PID, state feedback, and so on. However, because the control is linear, non-linear control has begun to be developed. Some of these controls, for example, use a sliding mode control system, fuzzy methods, and controls by combining linear control with artificial intelligence. This paper will use PID control and an artificial neural network for the quadrotor direction control system. The results of this control test indicate that the combination of PID and RNN on the directional control shows a better response than conventional PID.
Design of a Liquid Tank Filling Control System Using PID
Authors: Anggara Bagas Putra , Ma'arif Alfian , Abu Nur Syuhadah
Published: January 2025

This research investigates the precise regulation of liquid filling in tanks, specifically focusing on water storage systems. It employs the Proportional-Integral-Derivative (PID) control method in conjunction with an HC-SR04 ultrasonic sensor and an Arduino Uno microcontroller. Given the paramount importance of water as a resource, accurate management of its storage is of utmost significance. The PID control method, known for its rapid responsiveness, minimal overshoot, and robust stability, effectively facilitates this task. Integrating the ultrasonic sensor and microcontroller further augments the precision of water level regulation. The article expounds upon the foundational principles of the PID control method and elucidates its application in the context of liquid tank filling. It offers a comprehensive insight into the hardware configuration, encompassing pivotal components such as the Arduino Uno microcontroller, HC-SR04 ultrasonic sensor, and the L298 driver responsible for water pump control. The experimental approach is meticulous, presenting results from tests involving the Proportional Controller, Proportional Integral (PI) Controller, and Proportional Integral Derivative (PID) Controller. These tests rigorously analyze the impact of varying Proportional Gain (Kp), Integral Gain (Ki), and Derivative Gain (Kd) parameters on crucial performance metrics such as response time, overshoot, and steady-state error. The findings underscore the critical importance of an optimal parameter configuration, emphasizing the delicate equilibrium between response speed, precision, and error minimization. This research significantly advances PID control implementation in liquid tank filling, offering insights that pave the way for developing more efficient liquid management systems across various sectors. The identified optimal parameter configuration is Kp = 5.0, Ki = 0.3, and Kd = 0.2.
Optimizing Banana Type Identification: An Support Vector Machine Classification-Based Approach for Cavendish, Mas, and Tanduk Varieties
Authors: Pamungkas Aji , Fadlil Abdul
Published: January 2025

This research focuses on addressing the need for improved efficiency in the agricultural sector, particularly in banana processing in Indonesia, where the demand for bananas is consistently high. To improve the efficiency of banana processing, the research proposes the development of a machine learning based solution for automatic banana type selection. This solution uses image data of three banana types (Cavendish, Mas, and Tanduked) captured by a microscopic camera. The images are subjected to feature extraction, and a Support Vector Machine (SVM) algorithm is used to train the model. The results are implemented in a graphical user interface (GUI). The experimental results show promising results, with an accuracy of 86.67%, a precision of 87.78%, and an error rate of 13.33%, achieved with SVM parameters of C = 1000 and a linear kernel. This automated approach provides a practical and sustainable solution to the labor-intensive manual banana variety selection process, thus increasing the efficiency of the banana processing industry.
A Novel of Energy Consumption Profile of a Shopping Center
Authors: Ruliyanta Ruliyanta , Setyadi Wismanto , Kusumoputro R. A. Suwodjo
Published: January 2025

Energy conservation in Indonesia is the primary choice made by the government of the Republic of Indonesia. It is undeniable that the highest consumption of a building is air conditioning energy, especially in a tropical environment like Indonesia. Air conditioning consumes between 40% and 80% of power in a high-rise building. The problem is how to find out the electricity usage profile and energy consumption index in a building that has been in operation for more than 20 years. This research aims to find the energy profile and calculate the energy consumption of a shopping center building. The method used is an Energy Audit according to SNI 6196. The energy consumption profile is an anomaly where the energy consumption for the air conditioning system is only 48%, while the average value in shopping centers in Indonesia is 62.9%. Meanwhile, the GFA energy consumption index is 23.11 kWh/m2/month or 277.3 kWh/m2/year. According to SNI 03-0196, the result is classified as an energy-intensive building. This value is close to the SNI 03-0196 standard for very energy-intensive building levels, which has values between 23.75 and 37.5 kWh/m2/month. Energy-saving opportunities are calculated by calculating the difference in the ECI value with the target ECI value. To increase the efficiency of energy consumption, this can be done by replacing the chiller unit which still uses a step type compressor. Apart from that, improving air conditioning insulation is very significant to overcome energy consumption problems. Adding green plants around buildings can also increase electrical efficiency.
Comparative Analysis of Machine Learning Models for Tree Species Classification from UAV LiDAR Data
Authors: Airlangga Gregorius
Published: January 2025

Forest ecosystems play a pivotal role in maintaining global biodiversity and climate balance. The precise identification of tree species via remote sensing technologies is vital for effective ecological surveillance and forest stewardship. This research conducts a comparative analysis of various machine learning algorithms for the binary classification of tree species utilizing LiDAR data captured by Unmanned Aerial Vehicles (UAVs). We analyzed a dataset featuring 192 trees from a diverse forest, employing models such as Logistic Regression, Support Vector Machine (SVM), Random Forest, K-Nearest Neighbors (KNN), Gradient Boosting, and Decision Trees. These models were assessed on their accuracy, precision, recall, and F1-scores to ascertain their efficacy. Our findings reveal that Logistic Regression and SVM were superior, achieving precision and recall scores up to 0.96, indicating their robust predictive capability. In contrast, KNN underperformed, suggesting the need for parameter refinement. Although ensemble methods demonstrated resilience, they were more prone to overfitting in comparison to the more straightforward Logistic Regression and SVM models. Preliminary data preprocessing and feature engineering techniques are discussed, enhancing the models' performance. This work enriches the domain of remote sensing and ecological monitoring by offering an in-depth evaluation of machine learning models for tree species classification, underscoring their advantages and constraints. It underscores the transformative potential of machine learning in refining ecological analysis precision, thereby aiding in the pursuit of sustainable forest management. Future research directions could include model refinement through advanced feature selection or the exploration of novel machine learning algorithms for improved classification accuracy.
Designing a Monitoring System and Optimizing Water Quality in Tilapia Farming Ponds in Phokecik Hamlet Using Ubidots
Authors: Efendi Muhammad Taufik Nur , Sulistiyowati Indah , Syahrorini Syamsudduha , Anshory Izza
Published: January 2025

There are several important factors to increase the success rate of tilapia farming. Among them is the regulation of water quality in the pond, which is still mostly done manually. Therefore, a water quality management tool for Ubidots-based tilapia fish farming ponds is made to facilitate tilapia fish farmers in regulating the quality of pond water automatically. so the importance of water quality management of tilapia fish farming ponds is a follow-up to reduce the failure rate in the cultivation process. The components used in this tool are Esp32 as a microcontroller, ph sensor as a water ph value detector, DS18B20 temperature sensor as water temperature detection and turbidity sensor as a water turbidity value detector, Ultrasonic sensor as a pool water level detector, LCD to display the value detected by the sensor, solenoid valve and water pump that functions to drain and fill the pool water. The conclusion of the results obtained from this device is that the device works well and helps tilapia fish farm owners to monitor and control water quality efficiently, although there are some obstacles such as delays due to internet connections. so maybe in the future it can add a solar cell as a power supply for the automatic control process in this system.