bluuebunny/crossref_metadata_2025 huggingface dataset:
Process Evaluation of a Complex Workplace Intervention to Prevent Musculoskeletal Pain in Nursing Staff: Results From INTEVAL_Spain.
Authors: Soler-Font Mercè , Ramada José Maria , Merelles Antoni , Amat Anna , Flor Carmen de la , Martínez Olga , Palma-Vasquez Claudia , Sancho Consuelo , Peña Pilar , Bültmann Ute , Zon Sander K. R. van , Serra Consol
Published: May 2021

Background: The nursing staff is an occupational group at high risk of musculoskeletal pain. Scientific evidence has shown that multifaceted interventions are more effective than those based on a single component to prevent musculoskeletal pain. INTEVAL_Spain was a complex workplace intervention to prevent and manage musculoskeletal pain among nursing staff. Objectives: This study performed a process evaluation of INTEVAL_Spain and aimed to examine whether the intervention was conducted according to the protocol, to investigate the fulfilment of expectations and the satisfaction of workers.Methods: The intervention was a two-armed cluster randomized controlled trial and lasted one year. The process evaluation included quantitative and qualitative methods. Quantitative methods were used to address the indicators of Steckler and Linnan’s framework. Data on recruitment was collected through a baseline questionnaire for the intervention and the control group. Reach and dose received were collected through participation sheets, dose delivered and fidelity through internal registries, and fulfilment of expectations and satisfaction were collected with two questions at 12-months follow-up. Qualitative methods were used for a content analysis of discussion groups at the end of the intervention led by an external moderator to explore satisfaction and recommendations. The general communication and activities were discussed, and final recommendations were agreed on. Data were synthesized and results were reported thematically.Results: The study was performed in two Spanish hospitals during 2016-2017 and 257 workers participated. Recruitment was 62% and 51% for the intervention and the control group, respectively. The reach of the activities ranged from 96% for participatory ergonomics to 5% for healthy diet. The number of sessions offered ranged from 60 sessions for Nordic walking to one session for healthy diet. Fidelity of workers ranged from 100% for healthy diet and 79% for participatory ergonomics, to 42% and 39% for Nordic walking and case management, respectively. Lowest fidelity of providers was 75% for case management and 82% for Nordic walking. Fulfilment of expectations and satisfaction ranged from 6.6/10 and 7.6/10, respectively, for case management to 10/10 together for the healthy diet session. Discussion groups revealed several limitations for most of the activities, mainly focused on a lack of communication between the Champion (coordinator) and the workers. Conclusions: This process evaluation showed that the implementation of INTEVAL_Spain was predominantly carried out as intended. Process indicators differed depending on the activity. Several recommendations to improve the intervention implementation process are proposed.Study registration: ISRCTN15780649
Development of a New Screening Method “Allele Matching Cut Off Score (AMCOS)” for Faster Kinship Analysis in Cases of Mass Disasters: A Proof of Concept Study
Authors: Kakkar Sonia , Sarma Phulen , Pannigrihi Inusha , Mandal S. P. , Kumawat R. K. , Shrivastava Pankaj
Published: May 2021

kinship analysis in forensic is based on calculation of respective kinship indices. But calculation of the same is possible only when the subject under identification has been associated to a particular population whose gene frequency data is available for the particular set of markers used in forensic practices. In case of the mass disasters where a huge number of individuals are to be identified, gathering the population frequency data and calculating the kinship indices can be an intricate progression requiring a lot of time and huge resources. The present study is based on allele matching score values which doesn’t require the use of allele frequency data to establish kinship. This method is based on the allele sharing approach which simply refers to the number of shared alleles (1 or 2) between two individuals; also known as identical by state (IBS) alleles which might have been inherited from a recent common ancestor in which the alleles are identical by descendent (IBD). In case of mass disasters this method can be used to narrow down the investigation by screening the number of related individuals which can further be confirmed with other tests if required. This method has been tested for various statistical parameters and has shown promising values which suggests the potential use of this method in forensic practice. This method has been tested on siblings and grandparent-grandchildren by using autosomal and X-STR markers both as the reference samples from parents can’t always be available. The present study also compares the results shown by autosomal and X-STR markers in siblings and grandparent-grandchildren identification, thereby suggesting the better set of markers for siblings and grandparent-grandchildren identification.
Aeollanthus Pubescens Benth Leaf Essential Oil: Its Chemical Composition and the Insecticidal Activity Against the Malaria Vector Anopheles Gambiae (Diptera: Culicidae)
Authors: BOHOUNTON Roméo Barnabé , Djogbenou Luc , Djihinto Oswald Yédjinnavênan , Dedome Oronce Sedjro-Ludolphe , Sovegnon Pierre Marie , Barea Bruno , Adomou Aristide , Villeneuve Pierre , Tchobo Fidèle Paul
Published: May 2021

Background: The use of synthetic insecticides is responsible for many cases of resistance in insects. Therefore, the use of natural molecules of ecological interest with insecticidal properties turns out to be an alternative approach to the use of synthetic insecticides. This study aims at investigating the larvicidal, adulticidal activity and the chemical composition of the essential oil of Aeollanthus pubescens Benth on the major malaria vector Anopheles gambiae.The leaves of Aeollanthus pubescens were collected in the South of the Republic of Benin.Methods: Three reference strains of Anopheles gambiae s.s. such as Kisumu, Kiskdr and Acerkis were used. The standard WHO guideline for larvicides evaluation was used and the chemical composition of the essential oil was analysed by gas chromatography coupled to mass spectrometry. Adult mosquitoes were exposed to the fragment nets coated with the essential oil for 3 min. Probit regression analysis was used for LC50 , LC95 , KDT50 , and KDT95 calculations. The difference between the mortality‐dose regressions for the different strains was analysed using the likelihood ratio test (LRT). The Log-rank test was performed to evaluate the difference in survival between the strains.Results: Fourteen components were identified representing 98.31% of the total of oil. The major components were carvacrol (51.06 %), thymyle acetate (14.01 %) and ɣ-terpinene (10.60 %). The essential oil has remarkable larvicidal properties with LC50 of 29.57, 22.95, and 28.37 ppm respectively on Kisumu, Acerkis and Kiskdr strains. With the fragment net treated at 165 µg/cm2, the KDT50 of both Acerkis (1.71 s, p < 0.001) and Kiskdr (2.67 s, p < 0.001) individuals were significantly lower than that of Kisumu (3.77 s). The lifespan of the three mosquito strains decreased respectively to one day for Kisumu (p < 0.001), two days for Acerkis (p < 0.001) and three days for Kiskdr (p < 0.001) compared to their control.Conclusion: Our findings show that the Aeollanthus pubescens essential oil is an efficient larvicide and adulticide against malaria vector Anopheles gambiae. This bioinsecticidal activity is a promising discovery for the control of the resistant malaria-transmitting vectors.
Phase 1b Study of Ramucirumab in Combination With Erlotinib or Osimertinib for Untreated EGFR-mutated Non–small Cell Lung Cancer Patients With Asymptomatic Brain Metastases
Authors: Kaneda Hiroyasu , Sawa Kenji , Daga Haruko , Okada Asuka , Nakatani Yuki , Atagi Shinji , Okishio Kyoichi , Tani Yoko , Matsumoto Yoshiya , Ogawa Koichi , Nakahama Kenji , Izumi Motohiro , Mitsuoka Shigeki , Kawaguchi Tomoya
Published: May 2021

Objectives: The study was designed to investigate the safety and tolerability of ramucirumab administered in combination with erlotinib or osimertinib for patients with untreated EGFR-mutated non–small cell lung cancer (NSCLC) and asymptomatic brain metastases, a patient subgroup in which these regimens have remained untested.Materials and methods: This multicenter phase 1b study (RELAY-Brain) consisted of two cohorts with three patients each. The two cohorts were assessed independently of one another and were not compared. Patients whose asymptomatic brain metastases had or had not undergone prior local therapy received ramucirumab (10 mg/kg) every 2 weeks plus either erlotinib (150 mg/day) or osimertinib (80 mg/day) until disease progression or intolerable toxicity. The primary objective of the study was to assess dose-limiting toxicity (DLT), defined as central nervous system (CNS) hemorrhage of grade ³2. Secondary end points included safety profile, objective response (systemic and intracranial), and disease control rate.Results: Six patients were enrolled in the study. Neither DLT nor serious or unexpected adverse events were observed. At the time of this analysis, discontinuation of the study drugs had also not occurred. One treatment-related adverse event of grade ³3 (hypertension of grade 3) was apparent. Common adverse events were generally manageable. The median number of ramucirumab administrations was 18.5 (range, 13 to 31), and there were no detected episodes of CNS hemorrhage. Four patients experienced at least one dose delay for ramucirumab, but there were no dose reductions or omissions for this drug. Five of the six patients showed an objective systemic response. Although only one patient had a measurable CNS lesion at baseline, a confirmed intracranial partial response was observed. Conclusion: Ramucirumab in combination with erlotinib or osimertinib showed promising safety and efficacy for EGFR-mutated NSCLC with brain metastases.Clinical trial registration: Japan Registry of Clinical Trials (jRCTs2051190027)
New Insights Into the Introgression Between Agropyron Cristatum P Genome and Wheat Genome
Authors: Zhang Zhi , Zhou Shenghui , Liu Weihua , Song Liqiang , Zhang Jinpeng , Han Haiming , Yang Xinming , Lin Yida , Li Xiuquan , Li Lihui
Published: May 2021

Agropyron cristatum (2n = 4x = 28, PPPP) is an important wild relative of common wheat and confers desirable agronomic traits to common wheat. A previous report showed that the wheat-A. cristatum 6P translocation line WAT655 carrying A. cristatum 6PS (0.81–1.00) exhibited high resistance to prevalent physiological races (CYR32 and CYR33). In this study, three disease resistance-related transcriptomes, which were mapped to A. cristatum 6PS (0.81–1.00) through the analysis of specific molecular markers, were searched from among A. cristatum full-length transcriptomes. Then, three disease resistance-related gene markers, A. cristatum P genome-specific markers, and fluorescence in situ hybridization (FISH)/genomic in situ hybridization (GISH) probes made from the DNA of three bacterial artificial chromosome (BAC) clones, three genes, and A. cristatum “Z559” were used to analyze the BC5F2 and BC5F2:3 genetic populations of the translocation line WAT655. The results revealed the introgression can spontaneously occur between A. cristatum P genome and wheat genome, and indicated the three genes could constitute a gene cluster according to the positions of their FISH signals. Additionally, kompetitive allele-specific PCR (KASP) markers of the three genes were developed to detect and acquire 24 wheat-A. cristatum breeding materials, which showed resistance to physiological races (CYR32 and CYR33) and other desirable agronomic traits according to the field investigation. In conclusion, our study not only provides new insights into the introgression between A. cristatum P genome and wheat genome, but also provides the desirable breeding materials for breeding practice.
Radiologic Criteria of Retropharyngeal Lymph Node Metastasis in Maxillary Sinus Cancer
Authors: Kosugi Yasuo , Suzuki Michimasa , Fujimaki Mitsuhisa , Ohba Shinichi , Matsumoto Fumihiko , Muramoto Yoichi , Kawamoto Terufumi , Oshima Masaki , Shikama Naoto , Sasai Keisuke
Published: May 2021

Objective: To determine the most appropriate radiologic criteria of metastatic retropharyngeal lymph nodes (RLNs) in patients with maxillary sinus cancer (MSC).Materials and Methods: We retrospectively evaluated 16 consecutive patients who underwent magnetic resonance imaging (MRI) before and after the treatment of locally advanced squamous cell carcinoma of the maxillary sinus. The minimal and maximal diameters of all RLNS were recorded. RLNs were classified as metastatic on the basis of the MRI follow-up (f/u). RLNs were considered non-metastatic if stable disease continued until the final MRI f/u and metastatic in cases with different evaluations (complete response, partial response, progressive disease) determined using Response Evaluation Criteria in Solid Tumours (RECIST) ver. 1.1. The receiver operating characteristic curve (ROC) and area under the curve (AUC) were used to assess the accuracy of various criteria in the diagnosis of metastatic RLNs. Results: Of the 34 RLNs in 16 cases observed on pretreatment MRI, 7 were classified as metastatic RLNs and 27 as non-metastatic RLNs. Using the radiologic criteria, metastatic RLNs tended to be diagnosed more accurately with the minimal axial diameter than with the maximal axial diameter (AUC; 0.97 vs. 0.73, p = 0.06). The most accurate size criterion of metastatic RLNs was a minimal axial diameter of 5 mm or larger, with an accuracy of 94.1% (32 of 34).Conclusions: The most appropriate radiologic criterion of metastatic RLNs in MSC is a minimal axial diameter of 5 mm or longer.
Novel 3D Structure of Silver Doped ZrO2 Combined Graphene-Based Mesopouros Silica Quaternary Nanocomposite for a Nonenzymatic Glucose Sensing Effects
Authors: Oh Won-Chun , Cho Kwang-Youn , Chanthai Saksit , Fatema Kamrun Nahar
Published: May 2021

We described the novel nanocomposite of silver doped ZrO2 combined graphene-based mesoporous silica (ZrO2-Ag-G-SiO2, ZAGS) in bases of low-cost and self-assembly strategy. Synthesized ZAGS were characterized through X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectrometry (EDX), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), Raman spectroscopy, Nitrogen adsorption-desorption isotherms, X-ray photoelectron spectroscopy (XPS), and Diffuse Reflectance Spectroscopy (DRS). The ZAGS as a enzyme-free glucose sensor active material toward coordinate electro-oxidation of glucose was considered through cyclic voltammetry in significant organic electrolytes, such as phosphate-buffer (PBS) at pH 7.4 and commercial urine. Utilizing ZAGS, glucose detecting may well be finished with effective electrocatalytic performance toward organically important concentrations with the current reaction of 9.0 × 10-3 mAcm-2 and discovery restrain of 0.05 mmol/L at the lowest potential of +0.2 V, thus fulfilling the elemental prerequisites for glucose detecting within the urine. Likewise, ZAGS cathodes can be worked for glucose detecting within the nearness of interferometer substances (e.g., ascorbic corrosive, lactose and starch) in urine at proper pH condition. Our results highlight the potential usages for subjective and quantitative electrochemical investigation of glucose through the ZAGS sensor for glucose detecting stage permitted within the urine concentration.
A model of multiple factors influencing learner retention in MOOC during the COVID-19 pandemic
Authors: Yu Zhonggen
Published: May 2021

The authors have requested that this preprint be removed from Research Square.
LncRNA expression profile, functional analysis and potential biomarkers in children with pancreaticobiliary maljunction
Authors: Zhao Lian , Shi San-li , Guo Wan-liang
Published: May 2021

Background

The present study was aimed to investigate the expression profile of long non-coding RNAs (lncRNAs) and its potential as biomarker for pancreaticobiliary maljunction (PBM).
Methods

The differential expression of lncRNA and messenger RNA (mRNA) from 15 pediatric patients with PBM and 15 control subjects were analyzed with microArray and validated with quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Gene Ontology enrichment and Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis were used to investigate the biological functions of these genes. The area under curve (AUC) of receiver operating characteristic (ROC) curve was used to predict the biomarker of lncRNA in PBM.
Results

There were 2915 mRNAs and 173 lncRNAs upregulated, 2121 mRNAs and 316 lncRNAs downregulated in PBM cases, respectively. The enriched GO associated with differentially expressed mRNA were extracellular matrix, extracellular region and kinetochore. The most enriched pathway of Protein digestion and absorption was associated with cancer and PI3K-Akt signaling. Cis- and Trans-target gene analysis indicated that mRNAs were predicted to be regulated by one lncRNA and one mRNA corresponded to several lncRNAs. The results showed that the expression trends of NR_110876, NR_132344, XR_946886 and XR_002956345 were consistent with the microarray results, and the difference was statistically significant NR_132344, XR_946886 and XR_002956345 (P < 0.05).The AUC of ROC curve was significant only for XR_946886 (0.837, P < 0.001).
Conclusion

The present study indicated that lncRNAs were involved the pathogenesis of common bile duct in PBM and XR_946886 would be biomarkers for PMB.
COVID-19 Decision Impacts: Vaccine Hesitancy, its Barriers and Impact Studies: Taking Bayelsa State as an Example.
Authors: Olalekan Raimi Morufu , Lucky Emeka Chisom , Okoyen Ebikapaye , Clement Angalabiri , Ogbointuwei Christopher , Babatunde Atoyebi
Published: May 2021

Background: Immunization is the foundation of the primary health care system, an indisputable human right as well as a global health and development success story, saving millions of lives yearly. We now have vaccines to prevent more than 20 life-threatening diseases, helping people of all ages live longer, healthier lives. Yet despite tremendous progress, far too many people around the world, including nearly 20 million infants yearly have insufficient access to vaccines. In some countries, progress has stalled or even reversed, and there is a real risk that complacency will undermine past achievements.Purpose: The current study aimed to explores vaccine hesitancy, its barriers and impact studies regarding COVID-19 decision impacts and to provide policy and decision makers and operational staff with evidence to inform decisions to promote vaccine uptake across Bayelsa State. Methods: A literature review tried to do a deep dive by using a variety of search engines such as Scopus, Research Gate, Mendeley, Summon, PubMed, Google Scholar, Hinari, Dimension, Academia, CAB Abstract, OARE Abstract, SSRN search strategy to retrieve research publications, “grey literature” and expert working group reports, including authors field experience.Findings: Absence of uniform methods of organization in the various health care facilities upon which we were obliged to rely. Thus, affecting the overall immunization programme and health system. Hence, policy must urgently address these challenges with emphasis on policy clarity while continuously improving infrastructure.Conclusions: The findings suggest that the involvement of community-based leaders can improve community participation and acceptance, while enhancing and strengthening integrated disease surveillance and adverse events following immunization (AEFI) monitoring and reporting systems; and conducting integrated advocacy and communications activities to promote demand for vaccination as part of increasing overall demand and acceptability of all essential PHC services. Thus, breaking barriers of vaccine hesitancy.
Marketing Strategies Used by U.S. Landscape Services Firms
Authors: Rihn Alicia L. , Torres Ariana , Barton Susan S. , Behe Bridget K. , Khachatryan Hayk
Published: May 2021

The landscape service sector is an important part of the environmental horticulture industry. However, research addressing factors impacting its business and marketing practices are scarce. This manuscript uses data collected via online and mail industry surveys in 2014 and 2019 to investigate U.S. landscape service firms’ advertising and marketing practices and different factors that influence their business strategies by firm type and size. Product mix, advertising method, and the importance of different business factors were impacted by firm type. Landscape service only firms had the most diverse product offerings, while firms with wholesale production had the least diversity. Landscape service only firms primarily used in-person and telephone advertising, while firms with wholesale production used a broader swath of advertising medias to reach a more diversified clientele. Overall, weather and labor-related factors had the most impact on landscaping firms’ business practices. Larger firms perceived labor factors as more important than smaller firms.
COMPARISON OF ALTERNATIVE PROPULSION SYSTEMS - A CASE STUDY OF A PASSENGER SHIP USED IN PUBLIC TRANSPORT
Authors:   Dept. of Aeronautics, Naval Architecture and Railway Vehicles Budapest University of Technology and Economics Budapest, Hungary, Zalacko Roland , Zöldy Máté , Simongáti Győző ,   Dept. of Automotive Technologies Budapest University of Technology and Economics Budapest, Hungary
Published: May 2021

The unique feature of river transport is given by the rivers' flow and the changing cross-sections of the riverbed. Most river vessels operate with a conventional propulsion system. Engine power should be scaled to the maximum expected power demand, which means that the engine is forced to run at medium or low load, almost always downstream and upstream for part of the operating time. In these cases, the engine's operating point is far from ideal, so there is an increase in specific fuel consumption. This is especially true for ships that are forced to stop and start frequently. An example for the circumstances mentioned above is the BKV-100 type ship operated at Budapest as a public transport vessel. A measurement on a schedule route revealed that with given environmental conditions (water level, river flow rate, etc.), the power installed in the vessel is almost double the maximum power demand measured. Due to this reason and to the differences in power demand of downstream and upstream, it may be technically worthwhile to replace the existing conventional propulsion system with an alternative propulsion system. Based on the measurements, in this paper the authors compare 4 alternative drive systems to the existing one with regards to fuel consumption and the investment costs. Beside this, a simple but effective fuel consumption estimation method and a simple cost-benefit analysis are also described.
miR-30e-5p Regulates Autophagy and Apoptosis by Targeting Beclin1 Involved in Contrast-induced Acute Kidney Injury
Authors: Liu Xiaoqin , Li Qingzhao , Sun Lixin , Chen Limei , Li Yue , Huang Beibei , Liu Yunshuang , Jiang Chunyang
Published: May 2021

Aims:

This study aims to verify if miR-30e-5p targets Beclin1 (BECN1), a
key regulator of autophagy, and investigate the function of miR-30e-5p and Beclin1
through mediating autophagy and apoptosis in contrast-induced acute kidney injury (CIAKI).

Methods:

Human renal tubular epithelial HK-2 cells were treated with Urografin to construct
a cell model of CI-AKI. Real-time reverse transcription-polymerase chain reaction
was used to detect gene expression. The dual-luciferase reporting assay and endogenous
validation were used to verify targeting and regulating function. The expressions of protein
were detected using Western blot. Cell proliferation was detected using methylthiazolyldiphenyl-
tetrazolium bromide (MTT) assay. Cell apoptosis was detected using terminal-
deoxynucleoitidyl transferase mediated nick end labeling assay, and autophagy was
detected using transmission electron microscopy.

Results:

HK-2 cells exposed to Urografin for 2 h induced a significant increase in
miR-30e-5p. miR-30e-5p had a targeting effect on Beclin1. Moreover, Urografin exposure
can enhance cell apoptosis by increasing caspase 3 gene expression and inhibiting
autophagy, which was induced by decreased Beclin1 expression regulated by
miR-30e-5p, thereby resulting in renal cell injury. Downregulation of miR-30e-5p or upregulation
of Beclin1 restored cell vitality by promoting autophagy and suppressing apoptosis
in Urografin-treated cells.

Conclusions:

Urografin increased the expression of miR-30e-5p in HK-2 cells and thus
decreased Beclin1 levels to inhibit autophagy, but induced apoptosis, which may be the
mechanism for CI-AKI.
Photopharmacology of Azo-Combretastatin-A4: Utilizing Tubulin Polymerization Inhibitors and Green Chemistry as the Key Steps
Authors: Rastogi Shiva K. , Dunnigan Jennifer K. , Towne Adelyne C. , Zhao Zhenze , Du Liqin , Brittain William J.
Published: May 2021

:

Tubulin Polymerization Inhibitors (TPIs) are promising ligands utilized in chemotherapy
for modern cancer treatment. However, the current TPIs exhibit many serious side
effects that may pose limitations in chemotherapy. Combretastatin A-4 (CA-4) is a natural
TPI that binds at the colchicine binding site located on microtubules. The only cis isomer of
CA-4 is bio-active; however, due to its short half-life, it isomerizes quickly to its bio-inactive
trans geometric isomer. For preventing shortcomings of CA-4, azobenzene based CA-4,
called azo-CA-4 (azo-CA-4) is identified as a novel TPI. The geometric isomerization of azo-
CA-4 can be controlled upon exposure to ultraviolet (UV) light to remotely control its bioactivity.
Cis-azo-CA-4 is 200-500 times more active (IC50 = 0.2-10 μM) than trans-azo-CA-4
(IC50 = 50-110 μM) against various cancer cell lines. Photo-pharmacology uses light to control
drug activity, introducing a unique mechanism to develop novel photo-responsive TPIs. Further, the green chemistry
approach using ethanol and water as a green solvent in the synthesis of azo-CA-4 delivers advanced methodology
in novel TPI development.
Sosyal Bilişsel Kuram Temelli Eğitimle Tip 1 Diyabetli Çocukların Hastalık Yönetiminin Desteklenmesi
Authors: DELİBAŞ Leyla , ERCİ Behice
Published: May 2021

Çocukluk dönemlerinde görülen Tip 1 diyabet; pankreasın beta hücrelerinin otoimmün veya otoimmün olmayan sebeplerle etkilenmesiyle ortaya çıkan insülin eksikliği ve hiperglisemiyle karakterize kronik metabolik bir hastalıktır. Diyabet etkili yönetildiğinde, diyabete bağlı komplikasyonlar geciktirilebilmekte ve hatta önlenebilmektedir. Diyabetli bireyin eğitimi; kendi kendine bakma gücünü kullanması konusunda bireyi desteklemektir. Diyabet eğitimi hastalığın yönetiminde anahtar rol oynamaktadır. Çocuklara verilecek eğitimlerde çocukların bireysel özellikleri ve öğrenme becerileri mutlaka göz önüne alınmalıdır. Diyabetli çocukların eğitimi sadece çocukların becerilerini geliştirmeye yönelik olmamalı, davranış değişikliğini de hedeflemelidir. Kişilerin bir davranışı uygulayabilmeleri için yalnızca davranış hakkında bilgiye sahip olmaları değil, davranışla ilişkili öz yeterlilik algısının da güçlü olması gerekir. Bandura'nın Sosyal Bilişsel Öğrenme Kuramı, eğitimin nasıl daha etkin verilebileceği sorusuna ışık tutar. Kuram temelli eğitim programı, doğru eğitim yöntemlerinin seçilmesine yön verir, böylece öğrenmeyi kolaylaştırarak verilen desteğin etkinliğini arttırır.
Intervention Use and Symptom Change With Unguided Internet-Based Cognitive Behavioral Therapy for Depression During the COVID-19 Pandemic: Log Data Analysis of a Convenience Sample
Authors: Oehler Caroline , Scholze Katharina , Reich Hanna , Sander Christian , Hegerl Ulrich
Published: May 2021

Background

Internet- and mobile-based interventions are most efficacious in the treatment of depression when they involve some form of guidance, but providing guidance requires resources such as trained personnel, who might not always be available (eg, during lockdowns to contain the COVID-19 pandemic).

Objective

The current analysis focuses on changes in symptoms of depression in a guided sample of patients with depression who registered for an internet-based intervention, the iFightDepression tool, as well as the extent of intervention use, compared to an unguided sample. The objective is to further understand the effects of guidance and adherence on the intervention’s potential to induce symptom change.

Methods

Log data from two convenience samples in German routine care were used to assess symptom change after 6-9 weeks of intervention as well as minimal dose (finishing at least two workshops). A linear regression model with changes in Patient Health Questionnaire (PHQ-9) score as a dependent variable and guidance and minimal dose as well as their interaction as independent variables was specified.

Results

Data from 1423 people with symptoms of depression (n=940 unguided, 66.1%) were included in the current analysis. In the linear regression model predicting symptom change, a significant interaction of guidance and minimal dose revealed a specifically greater improvement for patients who received guidance and also worked with the intervention content (β=–1.75, t=–2.37, P=.02), while there was little difference in symptom change due to guidance in the group that did not use the intervention. In this model, the main effect of guidance was only marginally significant (β=–.53, t=–1.78, P=.08).

Conclusions

Guidance in internet-based interventions for depression is not only an important factor to facilitate adherence, but also seems to further improve results for patients adhering to the intervention compared to those who do the same but without guidance.
Social Representations of e-Mental Health Among the Actors of the Health Care System: Free-Association Study (Preprint)
Authors: Morgiève Margot , Mesdjian Pierre , Las Vergnas Olivier , Bury Patrick , Demassiet Vincent , Roelandt Jean-Luc , Sebbane Déborah
Published: May 2021

BACKGROUND

Electronic mental (e-mental) health offers an opportunity to overcome many challenges such as cost, accessibility, and the stigma associated with mental health, and most people with lived experiences of mental problems are in favor of using applications and websites to manage their mental health problems. However, the use of these new technologies remains weak in the area of mental health and psychiatry.

OBJECTIVE

This study aimed to characterize the social representations associated with e-mental health by all actors to implement new technologies in the best possible way in the health system.

METHODS

A free-association task method was used. The data were subjected to a lexicometric analysis to qualify and quantify words by analyzing their statistical distribution, using the ALCESTE method with the IRaMuTeQ software.

RESULTS

In order of frequency, the terms most frequently used to describe e-mental health in the whole corpus are: “care” (n=21), “internet” (n=21), “computing” (n=15), “health” (n=14), “information” (n=13), “patient” (n=12), and “tool” (n=12). The corpus of text is divided into 2 themes, with technological and computing terms on one side and medical and public health terms on the other. The largest family is focused on “care,” “advances,” “research,” “life,” “quality,” and “well-being,” which was significantly associated with users. The nursing group used very medical terms such as “treatment,” “diagnosis,” “psychiatry”,” and “patient” to define e-mental health.

CONCLUSIONS

This study shows that there is a gap between the representations of users on e-mental health as a tool for improving their quality of life and those of health professionals (except nurses) that are more focused on the technological potential of these digital care tools. Developers, designers, clinicians, and users must be aware of the social representation of e-mental health conditions uses and intention of use. This understanding of everyone’s stakes will make it possible to redirect the development of tools to adapt them as much as possible to the needs and expectations of the actors of the mental health system.
Understanding Perceptions and Practices for Designing an Appropriate Community-Based Kangaroo Mother Care Implementation Package: Qualitative Exploratory Study (Preprint)
Authors: Ariff Shabina , Maznani Ikram , Bhura Maria , Memon Zahid , Arshad Tayyaba , Samejo Tariq Ahmed , Zaidi Shujaat , Umer Muhammad , Ahmed Imran , Habib Muhammad Atif , Soofi Sajid Bashir , Bhutta Zulfiqar A
Published: May 2021

BACKGROUND

Low birth weight (LBW) is a common outcome of preterm birth, which increases the risk of an infant’s morbidity and mortality. Approximately 20 million infants are born with LBW globally per year. Since a significant number of births in Pakistan take place at home, it is important to focus on the use of kangaroo mother care (KMC), the practice of skin-to-skin contact, in communities to prevent neonatal mortality and morbidity.

OBJECTIVE

We employed a formative research approach to understand the context of communities and facilities with regard to neonatal care and KMC practice. The broader aims were to inform the design and delivery of culturally appropriate platforms to introduce KMC in communities, and develop effective recruitment and retention strategies of KMC in rural areas of the Dadu district in the Sindh province of Pakistan.

METHODS

We conducted focus group discussions, in-depth interviews, and key informant interviews with families of LBW babies, community members, health care providers, and hospital administrators to identify barriers, enablers, and a knowledge base for KMC interventions.

RESULTS

Newborn care practices in communities were found to be suboptimal. The community was generally unaware of the KMC intervention for the care of LBW babies. However, facility health care providers, the community, and family members were willing to provide KMC to improve outcomes. We found significant support from the community members and health care providers for KMC practices. Mothers were also ready to provide intermittent KMC. The administrative staff at the hospitals accepted the introduction of KMC practices for LBW babies.

CONCLUSIONS

KMC as a method of treating LBW babies is widely accepted in the community. This formative research provides strategically valuable information that will be helpful for developing effective implementation strategies by identifying common community practices for LBW babies, along with identifying the barriers and enablers to KMC practice.
Pengaruh Tax Amnesty E-Filing dan Sanksi Perpajakan Terhadap Kepatuhan WPOP di Kabupaten Badung Selatan
Authors: Maharani Ni Kadek Anik , Datrini Luh Kade , Larasdiputra Gde Deny
Published: May 2021

This research raises the title "The Effect of Tax Amnesty, E-Filling, and Tax Sanctions on Individual Taxpayer Compliance in South Badung Regency". This study aims to re-test empirically the effect of the dependent variable (X₁, X₂, X₃), which consists of tax amnesty, e-filing and tax sanctions on the independent variable (Y) of WP compliance. In this study, it has a population of 125,329 WPOPs. The data collection method in this research is through distributing questionnaires. In this study, using a sample who accidentally met the WP as many as 100 respondents. In this study using multiple linear regression analysis. According to the analysis and testing that has been carried out, it can be concluded that a person's compliance in carrying out his tax obligations is influenced by tax amnesty, e-filing and tax sanctions. This study uses hypothesis testing, statistical t test. With the testing that has been done, there are research results of the three variables that have a positive effect on WPOP Compliance in South Badung Regency.
Pengaruh Partisipasi Anggaran, Akuntabilitas Publik dan Gaya Kepemimpinan Terhadap Kinerja Manajerial Pada Organisasi Perangkat Daerah Kabupaten Bangli
Authors: Dewi Luh Putu Widyasari , Sastri Ida I Dewa Ayu Manik , Sanjaya I Ketut Puja Wirya
Published: May 2021

Penelitian ini bertujuan untuk menguji pengaruh partisipasi anggaran terhadap kinerja manajerial, untuk menguji pengaruh akuntabilitas publik terhadap kinerja manajerial dan untuk menguji pengaruh gaya kepemimpinan terhadap kinerja manajerial pada Organisasi Perangkat Daerah Kabupaten Bangli. Populasi dalam penelitian ini adalah orang yang menjabat dalam kinerja manajerial Organisasi Perangkat Daerah Kabupaten Bangli dan pengambilan sampel menggunakan metode sampel jenuh yaitu sejumlah 65 responden. Jenis data merupakan data kuantitatif dengan sumber data primer berupa kuesioner. Teknik analisis yang digunakan adalah analisis regresi linier berganda, uji t, uji F dan analisis koefisien determinasi menggunakan SPSS version 23 For Windows. Hasil penelitian menunjukan bahwa partisipasi anggaran berpengaruh positif dan signifikan terhadap kinerja manajerial, akuntabilitas publik berpengaruh positif dan signifikan terhadap kinerja manajerial dan gaya kepemimpinan berpengaruh positif dan signifikan terhadap kinerja manajerial pada Organisasi Perangkat Daerah Kabupaten Bangli. Adapun besar pengaruh variabel partisipasi anggaran, akuntabilitas publik dan gaya kepemimpinan adalah 94.3% sedangkan sisanya 5,7% dipengaruhi oleh variabel lain yang tidak dibahas dalam penelitian ini.
KERUGIAN KONTRAKTOR AKIBAT WASTE MATERIAL PROYEK KONSTRUKSI GEDUNG BERTINGKAT
Authors: Hendrik Sulistio  , Mega Waty
Published: May 2021

Waste dalam bidang konstruksi dapat diartikan sebagai kehilangan atau kerugian berbagai sumber daya yaitu material, waktu (yang berkaitan dengan tenaga kerja dan peralatan) dan modal, yang di akibatkan oleh kegiatan-kegiatan yang membutuhkan biaya secara langsung maupun tidak langsung tetapi tidak menambah nilai kepada produk akhir bagi pihak pengguna jasa Penelitian ini dilakukan pada 64 responden  proyek konstruksi gedung  untuk mengetahui besarnya kerugian akibat beton ready mix dan penyebabnya. Penelitian dengan menggunakan kuesioner yang disebarkan melalui system online. Dari 64 responden menghasilkan 9.06% yang merupakan kerugian beton ready mix. Kerugian beton Ready Mix adalah 9.06 % dari profit Beton Ready Mix. Dari uji validitas dan uji reliabilitas menghasilkan 18 faktor penyebab yang menyebabkan kerugian waste material beton ready mix. Faktor Penyebab kerugian beton ready mix yang terbesar adalah: hilang karena dicuri, adanya perubahan desain, pendetailan gambar yang rumit dan pesanan material yang tidak sesuai dengan spesifikasi dan tercecer pada saat diangkut/dipindahkan.
Qualitative and quantitative evaluation of the phytochemical constituents of three wood species in Ogun state, Nigeria
Authors:   Department of Forestry and Wildlife Management, Federal University of Agriculture Abeokuta, Abeokuta, Ogun State, Nigeria, Ogunjobi K. M. , Abdulwahab S. O. ,   Department of Forestry and Wildlife Management, Federal University of Agriculture Abeokuta, Abeokuta, Ogun State, Nigeria, Gakenou O. F. ,   Department of Forestry and Wildlife Management, Federal University of Agriculture Abeokuta, Abeokuta, Ogun State, Nigeria, Thompson O. E. ,   Department of Forestry and Wildlife Management, Federal University of Agriculture Abeokuta, Abeokuta, Ogun State, Nigeria, Olorunfemi O. ,   Department of Forestry and Wildlife Management, Federal University of Agriculture Abeokuta, Abeokuta, Ogun State, Nigeria
Published: May 2021

Studies on the phytochemicals of the stem wood of tropical trees are scarce, despite its importance to plant protection and preservation as most researches focused on their leaves and fruits. This research work aimed to qualitatively and quantitatively analyze the phytochemicals present in the stem wood of Gmelina arborea, Tectona grandis and Anogeissus leiocarpus. Freshly sawn timbers were collected from a local sawmill and then grounded into finely powdered wood samples. The powdered wood samples and its extracts were screened for the presence or absence of phytochemicals using standard methodologies. The qualitative screening revealed the presence of various secondary metabolites such as tannin, saponin, steroids, flavonoid, alkaoids and terpene in all the three species. The result also showed that Tectona grandis had the highest percentage of Alkaloid (7.5%), Tannin (4.95%), and Flavonoid (4.67%) while Anogeissus leiocarpus had the highest percentage of Saponin (3.06%) and Terpene (1.45%). This study established the fact that the three selected species studied have potentials in the industries for medicinal and anti-pathogenic usages.
ON CREATIVITY THROUGH MATHEMATIZATION IN SOLVING NON-ROUTINE PROBLEMS
Authors: Arifin Sujinal , Zulkardi Zulkardi , Putri Ratu Ilma Indra , Hartono Yusuf
Published: May 2021

This study aimed to describe and compare the students’ fluency, flexibility, and originality in solving non-routine problems in the Palembang context. They were depicted from the student’s fluency, flexibility, and originality of solving the horizontal and vertical mathematization forms. This qualitative study employed. The subjects of this study were 30 students of grade nine of junior high schools in Palembang. The instruments used were tests and interviews. The tests were employed to investigate the written horizontal and vertical mathematizations forms. Meanwhile, the interviews were to explore the students’ ideas with inadequately detailed answers. Then, the test and interview data were reduced and grouped based on the indicators of creativity. The reduced data were presented in a descriptive form for conclusions. The results of the data analysis showed that the high-ability students were the most fluent and flexible in solving the problems. Still, the provided solutions were less original and tended to use formal mathematics in the forms of formulas, symbols, and operations. Meanwhile, the moderate-ability students tended to start to solve problems by simplifying them, then presenting them in visual images. The answer sheets of the moderate-ability students revealed their fluency in understanding the problems and solutions, flexibility, and originality of thinking. This study obtained different results from the low-ability students who tended to have difficulties understanding the problems and made many errors in solving them.  Such a condition showed their inability to write the known data and relate the data to other facts they had already learned. As a result, their answers did not represent fluency, flexibility, and originality.
Uz modeļiem balstīta daudzobjektu biosistēmas precīzā datorvadība = Model based precision computer control of the multiobject biosystem
Authors:   ,   Latvia University of Life Sciences and Technologies, Zacepins Aleksejs
Published: May 2021

Doctoral thesis had been developed in the period from September 2009 until September 2012 in Department of Computer Control of Faculty of Information Technologies, Latvia University of Agriculture. The PhD thesis consists of 152 pages, which include 13 tables, 108 figures and 7 annexes. For the development of this paper 150 literature sources were used including 141 in foreign languages. The aim of the thesis is to improve the implementation of Precision Agriculture approach using the integration of various mathematical models in computer control of a multiobject biosystem. In order to achieve the aim of the PhD thesis several tasks were completed 1. Analyze the implementation of sensor networks and computer control in biosystem control and Precision Agriculture. 2. Analyze automatized control system development principles for biosystem control. 3. Develop a model based automatized computer control system architecture for biosystem control. 4. Develop an individual biological object monitoring and control system for Precision Agriculture realization for the honey bee wintering process. 5. Evaluate usability of the developed system for the bee colony state evaluation and control during the wintering process. The content of the PhD thesis: it is structured according to the aim and the tasks of PhD thesis consisting of 4 chapters. First chapter includes analysis of the application of computer control in Precision Agriculture and in biosystem control. The methodology for the application of the sensor network for biological system monitoring is provided. This chapter also provides introduction to practical work problematic. Second chapter includes description of the author developed model based control system architecture for the biological process monitoring and control. It emphasizes the focus on application of various multi-dimensional models for the decision support system realization. Third chapter includes detailed and sequent description of the bee wintering process control and monitoring task completion. In fourth chapter experimental data of the bee colony behaviour during the wintering process is summarized and analyzed. The precision of the bee colony temperature measurement system is evaluated. Calculations for commercial deployment of the system are provided. The main results, conclusions and future development prospects are described in the conclusion of the PhD thesis.
Hemodialysis-Related Glycemic Disarray Proven by Continuous Glucose Monitoring: Glycemic Markers and Hypoglycemia
Authors: Hayashi Akinori , Shimizu Naoya , Suzuki Agena , Matoba Kenta , Momozono Akari , Masaki Tsuguto , Ogawa Akifumi , Moriguchi Ibuki , Takano Koji , Kobayashi Naoyuki , Shichiri Masayoshi
Published: May 2021

OBJECTIVE

There is a high risk of asymptomatic hypoglycemia
associated with hemodialysis (HD) using glucose-free dialysate; therefore, the
inclusion of glucose in the dialysate is believed to prevent intradialytic
hypoglycemia. However, the exact glycemic fluctuation profiles and frequency of
asymptomatic hypoglycemia using dialysates containing >100 mg/dL glucose
have not been determined.

RESEARCH
DESIGN AND METHODS

We evaluated the glycemic profiles of 98 type 2 diabetes
patients undergoing HD (68 men, HbA1c 6.4±1.2%, glycated albumin 20.8±6.8%)
with a dialysate containing 100, 125, or 150 mg/dL glucose using continuous
glucose monitoring.

RESULTS

Sensor glucose level (SGL) showed a sustained decrease
during HD, irrespective of the dialysate glucose concentration, and reached a
nadir that was lower than the dialysate glucose concentration in 49 participants
(50%). Twenty-one participants (21%) presented with HD-related hypoglycemia,
defined by an SGL <70 mg/dL during HD and/or between the end of HD and their
next meal. All these hypoglycemic episodes were asymptomatic. Measures of
glycemic variability calculated using the SGL data (standard deviation,
coefficient of variation, and range of SGL) were higher and time below range
(<70 mg/dL) was lower in participants who experienced HD-related
hypoglycemia than in those who did not, whereas time in range between 70 and
180 mg/dL, time above range (>180 mg/dL), HbA1c and GA of the two groups
were similar.

CONCLUSIONS

Despite the use of dialysate containing 100–150 mg/dL
glucose, diabetic HD patients experienced HD-related hypoglycemia unawareness
frequently. SGL may fall well below the dialysate glucose concentration toward
the end of HD.