bluuebunny/crossref_metadata_2025 huggingface dataset:
Hepatitis E Seroprevalence and Detection of Genotype 3 Strains in Domestic Pigs from Sierra Leone Collected in 2016 and 2017
Authors: Suluku Roland , Jabaty Juliet , Fischer Kerstin , Diederich Sandra , Groschup Martin H. , Eiden Martin
Published: April 2024

Hepatitis E virus (HEV) is the main cause of acute hepatitis in humans worldwide and is responsible for a large number of outbreaks especially in Africa. Human infections are mainly caused by genotypes 1 and 2 of the genus Paslahepevirus, which are exclusively associated with humans. In contrast, viruses of genotypes 3 and 4 are zoonotic and have their main reservoir in domestic and wild pigs, from which they can be transmitted to humans primarily through the consumption of meat products. Both genotypes 3 and 4 are widespread in Europe, Asia, and North America and lead to sporadic cases of hepatitis E. However, there is little information available on the prevalence of these genotypes and possible transmission routes from animal reservoirs to humans in African countries. We therefore analysed 1086 pig sera collected in 2016/2017 in four districts in Sierra Leone for antibodies against HEV using a newly designed in-house ELISA. In addition, the samples were also analysed for HEV RNA by quantitative real-time RT-PCR. The overall seroprevalence in Sierra Leone was low with only 44 positive sera and a prevalence of 4.0%. Two serum pools were RT-PCR-positive and recovered partial sequences clustered into the genotype 3 (HEV-3) of the order Paslahepevirus, species Paslahepevirus balayani. The results are the first evidence of HEV-3 infection in pigs from Sierra Leone and demonstrate a low circulation of the virus in these animals to date. Further studies should include an examination of humans, especially those with close contact with pigs and porcine products, as well as environmental sampling to evaluate public health effects within the framework of a One Health approach.
Measles Virus-Based Vaccine Expressing Membrane-Anchored Spike of SARS-CoV-2 Inducing Efficacious Systemic and Mucosal Humoral Immunity in Hamsters
Authors: Yang Zhi-Hui , Song Yan-Li , Pei Jie , Li Song-Zhuang , Liu Rui-Lun , Xiong Yu , Wu Jie , Liu Yuan-Lang , Fan Hui-Fen , Wu Jia-Hui , Wang Ze-Jun , Guo Jing , Meng Sheng-Li , Chen Xiao-Qi , Lu Jia , Shen Shuo
Published: April 2024

As SARS-CoV-2 continues to evolve and COVID-19 cases rapidly increase among children and adults, there is an urgent need for a safe and effective vaccine that can elicit systemic and mucosal humoral immunity to limit the emergence of new variants. Using the Chinese Hu191 measles virus (MeV-hu191) vaccine strain as a backbone, we developed MeV chimeras stably expressing the prefusion forms of either membrane-anchored, full-length spike (rMeV-preFS), or its soluble secreted spike trimers with the help of the SP-D trimerization tag (rMeV-S+SPD) of SARS-CoV-2 Omicron BA.2. The two vaccine candidates were administrated in golden Syrian hamsters through the intranasal or subcutaneous routes to determine the optimal immunization route for challenge. The intranasal delivery of rMeV-S+SPD induced a more robust mucosal IgA antibody response than the subcutaneous route. The mucosal IgA antibody induced by rMeV-preFS through the intranasal routine was slightly higher than the subcutaneous route, but there was no significant difference. The rMeV-preFS vaccine stimulated higher mucosal IgA than the rMeV-S+SPD vaccine through intranasal or subcutaneous administration. In hamsters, intranasal administration of the rMeV-preFS vaccine elicited high levels of NAbs, protecting against the SARS-CoV-2 Omicron BA.2 variant challenge by reducing virus loads and diminishing pathological changes in vaccinated animals. Encouragingly, sera collected from the rMeV-preFS group consistently showed robust and significantly high neutralizing titers against the latest variant XBB.1.16. These data suggest that rMeV-preFS is a highly promising COVID-19 candidate vaccine that has great potential to be developed into bivalent vaccines (MeV/SARS-CoV-2).
Zika Virus: A Neurotropic Warrior against High-Grade Gliomas—Unveiling Its Potential for Oncolytic Virotherapy
Authors: Calderón-Peláez María-Angélica , Maradei Anaya Silvia , Bedoya-Rodríguez Ingrid , González-Ipuz Karol , Vera-Palacios Daniela , Buitrago Isabella , Castellanos Jaime , Velandia-Romero Myriam
Published: April 2024

Gliomas account for approximately 75–80% of all malignant primary tumors in the central nervous system (CNS), with glioblastoma multiforme (GBM) considered the deadliest. Despite aggressive treatment involving a combination of chemotherapy, radiotherapy, and surgical intervention, patients with GBM have limited survival rates of 2 to 5 years, accompanied by a significant decline in their quality of life. In recent years, novel management strategies have emerged, such as immunotherapy, which includes the development of vaccines or T cells with chimeric antigen receptors, and oncolytic virotherapy (OVT), wherein wild type (WT) or genetically modified viruses are utilized to selectively lyse tumor cells. In vitro and in vivo studies have shown that the Zika virus (ZIKV) can infect glioma cells and induce a robust oncolytic activity. Consequently, interest in exploring this virus as a potential oncolytic virus (OV) for high-grade gliomas has surged. Given that ZIKV actively circulates in Colombia, evaluating its neurotropic and oncolytic capabilities holds considerable national and international importance, as it may emerge as an alternative for treating highly complex gliomas. Therefore, this literature review outlines the generalities of GBM, the factors determining ZIKV’s specific tropism for nervous tissue, and its oncolytic capacity. Additionally, we briefly present the progress in preclinical studies supporting the use of ZIKV as an OVT for gliomas.
Cause Analysis of Salinity Intrusion by Environmental Changes Considering Water Intake and Sand Mining on Seomjin River Estuary Using Model for Maintaining Corbicula Habitats
Authors: Jung Chunggil , Lee Gayeong , Park Jongyoon
Published: April 2024

Anthropogenic development can strongly influence natural river processes, leading to environmental changes that negatively affect important habitats and biodiversity and consequently reduce economically important natural resources. This study investigated the effects of salinity intrusion on the habitat of the clam Corbicula japonica in the Seomjin River estuarine zone. We employed the Environmental Fluid Dynamics Code (EFDC) model, which incorporates topographic data and hydrological changes, to simulate salinity. Two salinity measurement facilities were installed in Seomjin River estuarine and operated to optimize the EFDC model. The results show that reduced flow rates due to intake have a negligible impact on the increased salinity. Maintaining optimal salinity (15–20 psu) during neap tides at the Seomjin River Bridge requires constant high flow rates, which poses significant challenges. Saltwater stratification is identified as the primary cause of pronounced salinity stratification, particularly during neap tides. Addressing this issue through river discharge and intake facility operation is challenging. Structural measures, including riverbed restoration and underwater barriers, are recommended to improve resistance to seawater intrusion. Future research should aim to develop scenarios to reduce salinity, quantify the reduction efficiency, and propose region-specific measures.
Game-Based Vehicle Strategy Equalization Algorithm for Unsignalized Intersections
Authors: Xiao Guangbing , Liu Kang , Sun Ning , Zhang Yong
Published: April 2024

To address the coordination issue of connected autonomous vehicles (CAVs) at unsignalized intersections, this paper proposes a game-theory-based distributed strategy equalization algorithm. To begin, the vehicles present in the scene are conceptualized as participants in a game theory. The decision-payoff function takes into account three critical performance indicators: driving safety, driving comfort, and driving efficiency. Then, virtual logic lines connect the front and rear extremities of vehicles with odd and even numbers at the intersection to create a virtual logic ring. By dividing the virtual logic ring into numerous overlapping game groups, CAVs can engage in negotiation and interaction within their respective game groups. This enables the revision of action strategies and facilitates interaction between the overlapping game groups. A further application of the genetic algorithm (GA) is the search for the optimal set of strategies in constrained multi-objective optimization problems. The proposed decision algorithm is ultimately assessed and certified through a collaborative simulation utilizing Python and SUMO. In comparison to the first-come, first-served algorithm and the cooperative driving model based on cooperative games, the average passing delay is decreased by 40.7% and 6.17%, respectively, resulting in an overall improvement in the traffic system’s passing efficiency.
A Zoonotic Strain of Rocahepevirus ratti Hepatitis E Virus Does Not Replicate Efficiently within Human Placental JEG-3 Cells
Authors: Yadav Kush Kumar , Hofstetter Jacob D. , Kenney Scott P.
Published: April 2024

Paslahepevirus balayani and Rocahepevirus ratti are genetically diverse species of hepatitis E virus [HEV]. Previously, only members of the Paslahepevirus genus were known to infect humans but recently some Rocahepevirus members have been found to be infectious to both immunocompromised and immunocompetent humans. Paslahepevirus balayani genotypes (gt) 1, 2, and 4 are known for their detrimental effects during pregnancy, causing pregnancy-related disorders. Recent findings have demonstrated the ability of Paslahepevirus balayani gt3 to replicate within placental cell lines, suggesting a direct effect on the placenta and fetus. To study whether zoonotic rat HEV strains possess a similar human-host placental tropism, we utilized JEG-3 cells to understand the replicative ability of an infectious clone of a recently reported strain of Rocahepevirus ratti, the LCK-3110 strain. Infectious cDNA clones of Pasla-, Avi-, and Rocahepevirus were transcribed and then, transduced into JEG-3 cells. Cells were harvested, and cell lysates were used for testing infectivity. Five days post-transfection or after inoculation onto naive HepG2/C3A cells, the cells were analyzed for infection. Replication in transduced JEG-3 cells and the infection potential in HepG2/C3A cells were assessed via an indirect immunofluorescence assay and a flow-cytometry assay. We found that the Rocahepevirus ratti LCK-3110 strain did not have efficient replication in JEG-3 cell cultures.
Speckle Tracking Echocardiography in Cats with Arterial Thromboembolism
Authors: Ertugrul Rozerin , Terzi Osman Safa , Özen Doğukan , Baştan İdil
Published: April 2024

Two-dimensional speckle tracking echocardiography (2D-STE) is a new approach developed for cardiac imaging that provides better assessment of regional and global myocardial abnormalities than standard echocardiography techniques. Latest studies have demonstrated that asymptomatic and mildly symptomatic patients with hypertrophic cardiomyopathy have variable areas of patchy myocardial fibrosis in left ventricular myocardium. However, no previous studies in cats with feline arterial thromboembolism (ATE) have used 2D-STE to assess myocardial function. The purpose of the study was to evaluate regional radial strain variables of the left ventricle using 2D-STE in cats with ATE. Ten cats affected with ATE and ten healthy control cats were studied. Cats with ATE, in the study group, were diagnosed with hypertrophic cardiomyopathy (HCM). This group was further divided into both intraventricular septum (IVS) and left vetricular (LV) hypertrophy (IVS-HCM, n:5) and only LV free wall hypertrophy (LV-HCM, n:5) groups. Compared to the control group, cats in LV-HCM and IVS-HCM groups had a thicker IVSd. LVFWd were considerably higher in LV-HCM group than in both IVS-HCM and the control group (8.04 ± 0.93, 4.9 ± 0.4, 3,91 ± 0,17 respectively, P
Porque Hamburgo não deve perder o filósofo Cassirer
Authors: Alves Vieira Neto Serzenando
Published: April 2024

Em junho de 1928, Aby Warburg publica no Hamburger Fremdenblatt uma obstinada defesa da permanência do filósofo Ernst Cassirer na cidade de Hamburgo. O texto, que representa um rico documento para o estudo da biografia de Warburg, é também um testemunho vivo da importância de Cassirer para o aprimoramento do estudo da imagem a partir da concepção do símbolo como substrato geral da expressão humana.
Micro Histórias, Conflitos e Apagamentos
Authors: Yang Klency
Published: April 2024

Este artigo tem como tema a ordem beneditina brasileira e a permanência do grupo após a formação do Estado laico no Brasil (1889). Os mosteiros brasileiros receberam religiosos europeus da mesma ordem, porém de outra congregação, com o fim de repovoamento; neste processo houve disputas políticas que reverberaram na arte. Este artigo tem como objetivo tratar desta reverberação, para tanto abordamos a micro história dos brasileiros em relação a macro história das casas envolvidas, foi um estudo de caso com exploração documental. Concluiu-se que houve uma sobreposição da arte dos beuronenses sobre a cultura local e houve a permanência de algumas pinturas parietais tendo como suporte o patrimônio arquitetônico brasileiro.
O que Oraibi deu à Aby Warburg? E o que ganha a América?
Authors: Risi Pereira Barreto Priscila
Published: April 2024

Para respondermos à dupla questão apresentada em nosso título, apresentamos pontos positivos e negativos relativos à viagem de Warburg à América, refletindo sobre o que demos e ganhamos com esta experiência. Discorrendo sobre aspectos da coleção de artefatos, fotografias e os dispersos registros deste encontro-desencontro, ressaltamos os desdobramentos de sua conceituação metodológica da história da arte, enquanto ciência da cultura, também considerando questões a serem superadas no âmbito da prática historiográfica. Demonstramos que sua experiência em campo ameríndio, de um lado, esbarra em questões relativas a estruturalismos e privilégios atual[1]mente debatidos no âmbito dos estudos decoloniais, de gênero e da estética (filosófica e psicológica). De outro, impelindo-nos à superação – ainda que de forma filosófica, mas sim política e prática, e não abstrata – com as atuais condições de crítica e “ocupação” na arte, também nos lega uma orientação epistemológica. Guiada por palavra, imagem, orientação e ação, multipliciza os olhos livres da história, desvela subjetividades, ambiguidades e coexistências, e amplia fronteiras, fontes e as noções acerca da arte e da cultura.
Dinámica viral y duración de la positividad de SARS-CoV-2 mediante la prueba de RT-PCR en tiempo real en estudiantes y personal docente que asisten a clases presenciales en la Universidad Mayor Real y Pontificia San Francisco Xavier de Chuquisaca
Authors: Barrera Carmen Delgado , Herrera Mariela Victoria Ancasi , Alacori Yhuliana Chile , Arando Vanessa Digna Alejo , Copa Angela Madai Huanca
Published: April 2024

La enfermedad por coronavirus (COVID-19) es una infección aguda de las vías respiratorias, se informó por primera vez en diciembre de 2019 en Wuhan, China, y ha sido declarada una emergencia de salud pública de interés internacional por la Organización Mundial de la Salud. La pandemia por el SARS-CoV-2 persiste a pesar de haberse administrado dosis de vacunas anti-COVID en todo el mundo. El método diagnóstico estándar es la reacción en cadena de la polimerasa con transcriptasa inversa en tiempo real (RT-PCR). La limitación de la prueba al reportar únicamente ausencia o presencia del RNA viral puede ampliarse al análisis del número de ciclos (Ct) para el alta de pacientes infectados contribuyendo en la toma de decisiones en los sistemas locales de salud, y la interpretación del contexto clínico-epidemiológico de los pacientes infectados. Aquí, examinamos el tiempo de duración en la que el virus SARS-CoV-2 es eliminado en muestras respiratorias positivas de estudiantes y personal docente que acuden a clases presenciales de la USFX mediante RT-PCR en tiempo real. Se discriminaron valores de Ct para usarlos en el diagnóstico, siendo aquellos con valor mayor o igual a 32 reportados como negativos. En el 35.5% que corresponde a pacientes con Ct igual o mayor a 32 no se observó presencia del material genético del virus a partir del primer día de control (día siguiente al diagnóstico) y los casos con valores de Ct menor a 32, que representan el 64.5%, eliminaron al virus dentro de los 6 días posteriores al diagnóstico. Se estandarizó el valor de Ct = 32 en un kit comercial multiplex como valor de corte para el diagnóstico. Los resultados sugieren que los casos positivos de COVID-19 eliminan el virus en un tiempo reducido razón por la que se podría considerar un período de aislamiento más corto y la incorporación a sus actividades diarias posterior a los 4 días de haber sido diagnosticados.
Association of Launch Price and Clinical Value With Reimbursement Decisions for Anticancer Drugs in China
Authors: Zhou Jing , Lu Hao , Pan Jay
Published: April 2024

Background: To investigate the association of launch price and clinical value with reimbursement decisions for anticancer drugs after the implementation of reimbursement-linked price negotiation in China. Methods: Anticancer drugs approved by the NMPA of China from January 2017 to June 2022 were eligible for inclusion. Approval and reimbursement dates of included drug indications were retrieved from publicly available resources. We collected measures of clinical value, including survival, quality of life, and overall response rate from pivotal clinical trials and calculated treatment price at launch. Univariate and multivariate Cox proportional hazards models were employed to estimate the association between launch price, clinical value, and reimbursement decisions of anticancer drugs in China. Results: The median reimbursement lag was 579 days (IQR: 402 - 936) for 93 indications supported by randomized controlled trials and 637 days (IQR 373 - 858) for 42 indications supported by single-arm clinical trials. Reimbursement was granted to 60 (65%) and 23 (55%) indications supported by randomized controlled and single-arm clinical trials, respectively. The launch price of anticancer drugs was not associated with reimbursement decisions in multivariate regression analyses. Indications supported by randomized controlled trials with higher clinical value were more likely to be reimbursed (HR for survival=1.07, 95%CI: 1.00 -1.15, p = 0.037), while the overall response rate of indications supported by single-arm clinical trials was not associated with the likelihood of being reimbursed (HR = 2.09, 95%CI: 0.14 - 32.28, p = 0.595). Conclusion: The launch price of anticancer drugs may not have a significant impact on reimbursement decisions, while the implementation of reimbursement-linked price negotiation in China has prioritized anticancer drugs with higher clinical value, but only for indications supported by randomized controlled trials. Efforts are needed to prioritize indications supported by single-arm clinical trials that have higher value during the process of price negotiation.
Chromate resistance in Cupriavidus metallidurans CH34: molecular
modeling from ChrC superoxide dismutase
Authors: Díaz-Pérez Alma Laura
Published: April 2024

Chromate has become an environmental pollutant present
in different ecosystems due to its use in industry. Bacteria
have evolved to resist stress produced by chromate.
Among chromate-resistance mechanisms we can list
Reactive Oxygen Species detoxification systems. CmeSOD (ChrC) protein from Cupriavidus metallidurans
CH34 is a superoxide dismutase that mitigate oxidative
stress caused by chromate. Cme-SOD protein belongs to
Fe and Mn-dependent SOD family (pfam02777). The
objective of this study was to analyze the threedimensional structure of the Cme-SOD protein, for which
monomer and tetramer models of the enzyme were built.
In the monomer model it was observed that Cme-SOD has
a characteristic two-domain structure from iron-dependent
SOD, additionally, Cme-SOD has an iron-binding site
formed by conserved residues H26 and H75 in the Nterminal domain, and D157 and H161 in the domain Cterminal domain. It was show that chromate stress
response SODs have a non-conserved residues in the
active site (R37, N59, S71, D143 and Y164). These
findings suggest the presence of a novel active site in this
family of enzymes.
Kinetics and diversity indices of phytoplankton in T ́zonot type watery
in Kopomá
Authors: Vizcaino-Rodríguez Luz Adriana
Published: April 2024

The cenotes, made up of a mixture of karst soil, fresh and
salt water, provide ecosystem services: water, climate,
landscape, and headquarters for religious and recreational
activities. They are niche species that are part of the
trophic chains and conserve valuable genetic information
product of their evolution and adaptation to the ecosystem.
It is important to know them before they can be lost due to
anthropogenic activities. The objective of this work was
to study the spatiotemporal biodiversity of phytoplankton
in the Chen Ha Cenote. Monitoring activities included
spring, summer and winter seasons. Environmental
variables were monitored with a multiparameter probe.
Classification of microorganisms by microscopy. The pH
was slightly alkaline in all monitoring results.
Temperature varied from 28.7 to 32 ° C, dissolved oxygen
ranged from 2.4 to 3.2 ppm. Conductivity was 2.962
during spring and 2650 microS.cm2
in wintertime. 41
species were identified in spring, 27 in summer and 29 in
winter. During the spring and winter seasons diatoms
predominated. Navícula, Coelosphaerium and Nitzschia
were the dominant species in spring, summer, and winter
periods, respectively. In accordance with the Jackard
similarity index, greater similarity was observed between
spring and winter showing a value of 0.458, compared to
summer with a value of 0.3877.
Analysis using the intelligence cycle and the Hoshin Kanri methodology in an organization
Authors: Dorantes-Benavidez Humberto
Published: April 2024

The lack of planning is not only a local problem, but of a
global nature, the consequences reflect the lack of
monetization, growth and strategic alliances that allow the
expansion of them. This research proposes to develop the
intelligence cycle and the Hoshin Kanri methodology in
an organization as a factor of change in Mexican
organizations. A current problem in every organization is
the lack of planning, it is not a local problem but a global
one. Taking into account the following factors such as:
Returns and delays in delivery within the organization, the
results are encouraging, going from 27% to 12% of returns
and from 26% to 10% in the reduction of delays. Through
the cycle (PDCA) the actions will be fed back together
with senior management seeks to feed back the actions
together with the management through a strategic
approach and inclusion of all the personnel of the
organization
Situational analysis to increase the competitiveness of the artisanal sector of San Antonio la Isla, State of Mexico
Authors: Aguirre-Brito Dorian
Published: April 2024

Mexico has distinguished itself as a country of enormous
cultural wealth, it is important to contribute to the growth
and consolidation of the aspects that identify us, one of
them is the production and marketing of handicrafts,
which are also representative of the regions of our country.
, the objective of this research work is to carry out a
situational analysis of the artisans of San Antonio la Isla,
State of Mexico and by determining the strategic balance
to identify the areas of opportunity and risk. The
methodology used is non-experimental research of a
descriptive transactional type since it seeks to investigate
the technological competence of the artisans through the
application of surveys, which is obtained as a result of the
evaluation of the variables mentioned below:
Differentiated and exclusive products, Value-added
process, Mastery of technology, Capacity for Innovation,
Strategic assets difficult to imitate, Productive flexibility,
Quality System. Derived from the situational analysis, the
FODA matrix was carried out where risk and opportunity
factors are identified and strategies are proposed to
increase the competitiveness of the artisanal sector.
HabitFun videogame as a tool to support the generation of good hygiene
habits in elementary school children
Authors: Luna-Carrasco Claudia Yadira
Published: April 2024

This research addresses the development of a video game
in Unity compiled for execution on devices with Android
Operating System, said video game as a support tool for
elementary school children to acquire good personal
hygiene habits. Sometimes, children can be careless when
it comes to their personal hygiene, and pediatricians
recommend from a very young age the hygiene habits that
they should follow daily, thus reducing the risk of
contracting any disease. On the other hand, it is sought that
the child is more organized, careful and self-demanding
with himself. The Unity engine and the agile Scrum
methodology were used for the development of the video
game. Personal hygiene can be more interesting if it is
taught through play, helping to demonstrate its
importance, whether in the classroom or at home, children
can learn about hygiene and find the right way to stay
clean, neat and healthy. Therefore, the video game
presents in text and audio, hygiene tips and each level is
an area of the home that represents a hygiene challenge
that the child must meet in order to move to the next level
Development of a web application for hotspot token vending machine
administration
Authors: Sampayo-Rodriguez Carmen Jeannette
Published: April 2024

This article describes the features of a web application to
manage the availability and acquisition of wireless internet
access credentials of vending machine, it followed the
OOHMD agile software development methodology, for
the implementation we used the client-server architecture,
the JavaScript programming language, the JavaScript
runtime environment of Node. js JavaScript runtime
environment, Express web development framework for
Node.js, Sequelize ORM, MySQL relational database
management system, Passport authentication middleware,
EJS open source template engine, Bootstrap CSS
framework, JSON data interchange format and Visual
Studio Code IDE. As a contribution, there is a web
application that allows the synchronization of available
tokens and the sale of a wireless internet access credential
vending machine, which connects through the internet.
The methodology used allowed to have an adequate
development process to obtain a quality product that
resulted in a web application that efficiently provides the
available access credentials and manages the access
credentials acquired from the vending machine.
Experimental and numerical calibration in a critical flow venturi of close
to sonic flow
Authors: Rivera-López Jesús Eduardo
Published: April 2024

This work introduces a new study in discharge coefficient
performance in CFV when the throat flow is close to
sonic regime Ma ≈ 1 and the throat strangulation is not
fully developed. Thus, two CFV of 0,56 and 2,24 mm
diameter were experimentally calibrated by applying the
volume averaging method; experimental calibration
allowed to estimate Cd and measure uncertainty, for 2,24
mm diameter Cd is 7,34% higher than for 0,56 mm
diameter when Ma global is 7,30 % higher. Based on
experimental calibration results and CFV geometries,
numerical experiments were realized to explain how Ma
≈ 1 flow deviates Cd from the theoretical value,
concluding compressibility affects thickness scrolling
relation since it is 35,92% smaller for 2,24 mm diameter
than 0,56 mm, giving a better approximation for Cd to
the theoretical value for this throat diameter. Finally,
numerical Cd models were obtained to evaluate the
deviation these flow conditions produce in respect of
empirical and numerical models, finding the numerical
model's maximum error is 6,68% and the empirical
model's maximum error is 1,64% under identical
stagnation conditions.
Evaluation of the adherence of thermoplastic polyurethane (TPU) as an alternative
material for the protection of solar cells
Authors: Salazar-Peralta Araceli
Published: April 2024

At present, the care of the environment as well as the use
of solar energy are of great importance. One way to use
solar energy for clean energy generation is through the use
of photovoltaic modules. The performance of the
crystalline silicon PV module is mainly determined by the
efficiency of the silicon cells, but the properties of the
other components, such as the encapsulant material, also
have a high impact. The objective of this study was to
evaluate the adherence of Thermoplastic Polyurethane
(TPU) as an alternative material for the protection of solar
cells, since the encapsulating material most used in solar
production to date is Ethylene vinyl acetate (EVA) and it
serves as a comparison of possible advantages and
disadvantages. The tests carried out were in accordance
with the International IEC 61215 and 61345 Standards.
The adhesion results were sufficiently good and without
optical defects. It is concluded that TPU can be used as an
alternative material for encapsulating solar cells.
Methodological proposal for a feasibility study for the implementation of a vertical warehouse for a Manufacturing Company in Southern Sonora
Authors: Bueno-Solano Alfredo
Published: April 2024

Inventory management has become a critical element in
modern supply chains. Globalization has led products and
services to travel longer distances at faster speeds,
resulting in extreme variations in demand and putting
pressure on production organizations to produce more and
faster. This research proposes a methodology to guide the
implementation of a vertical warehouse for a
manufacturing company in southern Sonora. The
organization aims to reduce material handling travel times,
have materials closer to the point of use, and improve
production efficiency. The methodology involves the
combination of methods and tools such as ABC inventory
classification, the use of the PUGH matrix, and the
Analytic Hierarchy Process (AHP) to select the option that
is technically, economically, and environmentally feasible
for the project. The study also includes a review of the
literature on vertical warehouses and their benefits. The
practical implications of this work are that it provides a
methodology for selecting a vertical warehouse that meets
the needs of an aerospace manufacturing company. The
proposed methodology can be used by other
manufacturing companies to determine the feasibility of
implementing a vertical warehouse and selecting the most
suitable option based on their specific needs and
requirements.
Strategies for early detection of students at risk of dropping out
Authors: Leyva-Maldonado Yadira
Published: April 2024

Dropout in Higher Education Institutions is a
widespread phenomenon that was exacerbated by the
Covid-19 pandemic. With the return to the new
normality, some institutions continue with high
dropout rates and even low enrollment, which harms
their indicators. The goal of this study is to know the
factors that allow identifying at an early stage,
students who are at risk of dropping out, which will
allow applying strategies to reduce this phenomenon.
Initially, a process of detecting students at risk began
by monitoring their academic performance. The
results are promising, since they allow generating a
profile of the student at risk of dropping out of their
studies.
Attitude, behavior and financial knowledge of young university students in Mexico
Authors: Décaro-Santiago Laura Angélica
Published: April 2024

Financial literacy, which includes the dimensions of
attitude, behavior and knowledge, is a condition for
individuals to achieve financial well-being. In the
population of young university students, it is a relevant
aspect since they begin the financial life cycle, with a
forecast of medium and high income, but whose
generation of wealth will depend on decision making.
Therefore, the objective of this paper is to measure the
level of financial literacy of students at the Universidad
Autónoma del Estado de México, in order to identify areas
of opportunity and gaps to address. For which an
instrument designed in Ecuador was applied, for the Latin
American context, which meets the necessary
psychometric levels. The sample consisted of 521
participants from various programs and educational spaces
that were close to graduation. Analysis was subject to
central and dispersion measures as well as non-parametric
group comparison tests. Among the results, it was
identified that most students are at a high level of financial
literacy, although the lowest score was obtained in the
knowledge dimension. Significant differences were found
in gender, by educational program, academic space and
employment status.
Proposal for measuring the impact of the quality of work life on business
competitiveness: expert panel method
Authors: Acosta-Mellado Erika Ivett
Published: April 2024

Objetive. Validate an instrument for determining the quality
of work life factors that affect business competitiveness,
taking several companies in the industrial sector as a case
study through the Content Expert Panel method.
Methodology. The research approach is quantitative, the aim
is to contrast the theory found with the empirical evidence in
the field. As the research developed, 3 research techniques
were used in order to comply with methodological rigor: 1)
Documentary technique. Reference materials: books,
database, techniques and studies. 2) Bibliographic technique.
Those used as support were: bibliographic and electronic
files. 3) Field Technique, structured interviews for the Expert
Panel.
Contribution. In the literary review, it was found that there is
statistically significant evidence on how improving the
quality of life of the members of the organization has a direct
impact on its performance, which is why, the better the
quality of life, the employees can become more competitive.
For future research, other validation techniques of the
proposed instrument could be implemented, as well as the
analysis of other theories related to quality of life and
competitiveness.
Design of a mechanism for applying sensitive films to gas sensors based on quartz crystal resonators
Authors: Lebonnois-Rodríguez Ian Denis
Published: April 2024

Gas sensors based on quartz crystal microbalance (QCM)
are used to measure mass changes through frequency shifts,
using the piezoelectric principle. These sensors are
employed in odor detection and are essential for the
development of electronic noses. For optimal performance,
a sensitive film is applied to the surface of the crystal
electrode, which is compatible with a specific compound.
There are different methods of film deposition: ultrasonic
atomization, spray coating, and casting. The casting method,
which involves the manual application of sensitive films
using a micropipette, is the most commonly used. However,
it is not reproducible. To improve the casting method, a
mechanism is proposed as a preliminary platform for a
sensitive film application system. The objective is to
achieve reproducibility in the construction of gas sensors by
applying ethyl cellulose sensitive films onto the sensor
surface, thereby reducing the margin of error. Tests were
performed on the mechanism to verify the capabilities of the
system for the deposition of sensing films using joysticks
based on the resistance change principle.
Identification of key factors for the implementation of a planning culture in micro and small businesses
Authors: Lázaro-Hernández Refugio
Published: April 2024

Planning as a business tool allows specifying and
establishing the objectives to be achieved, as well as the
operational processes that must be followed to achieve
them. However, the main factors that cause failure or
mortality in micro and small enterprises (mses) in the
Mexican territory are mainly attributed to three factors: the
absence of a planning culture, the problems derived from
the management of the organization and resistance to
change. The objective of this research was the
identification of factors that positively influence the
implementation of a planning culture in the mses of the
Texmelucan region, through the development and
application of a measurement instrument with a Likerttype scale. As a contribution, they highlight four key
factors to consider; organizational structure, human
capital, production and planning, as organizational
development tools, in order to maintain competitiveness
and permanence of these.
Design of experiments (DOE) of parts manufactured in 3D printers using composed filaments of PLA and Aluminum
Authors: López-Corella José Alejandro
Published: April 2024

The Department of Mechanical Metal (Mechatronic
Engineering) of the Technological Institute of Nogales
was one of the first national degrees to offer in its study
plans the specialty of plastic injection molding (IMCEMIP-2017-01), with the eager to continue innovating and
evolving in this area, we present the following research
work, with which we experimented and generated
knowledge to determine the mechanical properties of parts
manufactured in 3D printers, with polymer composite
materials (PLA) and metallic powders ( Aluminum). In the
first place, the filament formed by a matrix of PLA and an
ALUMINUM reinforcement was created, which was
extruded in a molding machine manufactured inside in the
molding laboratory of this Institute, taking as
consideration that the reinforcing material in this case
aluminum the following percentages will be 0% and 20%.
Placing these filaments in a suitable printer for the
manufacture of 3D parts with composite materials to
which an analysis of experiments was performed to
determine what percentage of composite material has
better mechanical properties
Low-cost Schlieren system for flow visualization in transparent media in the wind
sector
Authors: Uribe-Castillo Citlali
Published: April 2024

The Schlieren technique is frequently used for qualitative
visualization of flow around an object. Temperature and
density change can also be obtained with this technique. In
this project, the aim was to develop a low-cost Schlieren
system starting from easily available materials and
commercial equipment. Cell phone holders were used as
supports to position the concave mirrors. A light-emitting
diode (LED) lamp was used as the illumination source,
while a knife, a condenser lens, and printed parts in PLA
(polylactic acid) plastic were key to the prototype
development. Preliminary results showed an effect with
limited visual perception due to the low temperature
change in the objects under examination. In later
experiments, qualitative visualization with a better degree
of visual perception was observed due to the higher
temperature range reached in the test. The images that
were obtained were satisfactory and they allowed
validation of the prototype development. Its main
application points to the visualization of transparent flows
that are formed in the airfoil of a wind turbine blade.
Diagnosis to determine the root cause of unproductive times in the release of ascorbic acid as a raw material
Authors: Gómez-Vicario Miguel Ángel
Published: April 2024

The present work was carried out in a company
dedicated to the elaboration of medicines and
food supplements, in which a diagnosis was
made in the raw material release process,
specifically, in ascorbic acid; where the critical
points of the release process that presented a
difference in time (unproductive time) were
detected in the analysis of the parameters of each
test of the raw material with respect to the
established time. The objective of this work was
to determine the root causes of unproductive
times that affect the release of raw material; the
methodology used was a study of times and
movements, process flow diagrams and route
diagrams. During development, the proposal for
traceability formats of the characteristics of the
raw material was designed.
Sensitization about the importance of the timely propertiews’ swuccwess.ieonc for family protection
Authors: Mina Susana del Carmen
Published: April 2024

The objective´s study is to sensitize the administrative
staff, the managerial staff and the teaching staff of the
Universidad Tecnológica del Sureste de Veracruz (UTSV)
about the importance of the timely succession of movable
and immovable property for a family protection.
Quantitative research was carried out, with a statistical
analysis, nonexperimental, a descriptive and crosssectional scope. The data collection technique is the
survey; the instrument is a questionnaire with twenty-nine
items and a comment section. Derived from the COVID19 pandemic, the surveys are applied through digital
media, Google Forms was used, with 111 surveys in total.
It is observed that sensitization of this topic is important
so that our relatives are protected and can make use of the
movable and immovable property of the owner as soon as
he dies. The fact that the owner determines how his
properties will be distributed and under what legal
procedure, will make it possible that, upon the death of
said owner, those relatives or designated persons have the
right to make use of the bequeathed assets.
Alih Kode Dan Campur Kode Dalam Pembelajaran Bahasa Indonesia Pada Era Industri Kreatif di SDN Bakaran Wetan 03
Authors: Sulistiyowati Sulistiyowati , Irfai Fathurohman
Published: April 2024

This research is research on the existence of code switching and code mixing in Indonesian language learning at SDN Bakaran Wetan 03. This research uses a qualitative descriptive method with the research subjects being teachers, principals and class V students. The results of data analysis show that learning at SDN Bakaran Wetan 03 code switching and code mixing occurs. The form of code switching in learning is internal code switching, namely from Indonesian to Javanese. The forms of code mixing in communication at SDN Bakaran Wetan 03 are in the form of word insertion code mixing, phrase code mixing, and clause code mixing. Factors that cause code mixing include (1) explaining something, (2) establishing familiarity, and (3) situations and conditions. The positive influence is the ease of communication for teachers and students. However, there is also a negative influence, namely destroying the structure of the Indonesian language.
Abstrak
Penelitian ini adalah penelitian tentang adanya alih kode dan campur kode pada pembelajaran Bahasa Indonesia di SDN Bakaran Wetan 03. Penelitian ini menggunakan metode deskriptif kualitatif dengan subjek penelitian adalah guru, kepala sekolah dan siswa kelas V. Hasil analisis data menunjuukkan Pada pembelajaran di SDN Bakaran Wetan 03 terjadi alih kode dan campur kode. Bentuk alih kode pada pembelajaran ada pada alih kode internal yaitu dari Bahasa Indonesia ke Bahasa Jawa. Bentuk campur kode pada komunikasi di SDN Bakaran Wetan 03 berupa wujud campur kode penyisipan kata, campur kode frasa, dan campur kode klausa. Faktor-faktor yang menjadi penyebab terjadinya campur kode antara lain (1) akan menjelaskan sesuatu (2) menjalin keakraban, dan (3) situasi maupun kondisi. Pengaruh positifnya adalah adanya kemudahan dalam berkomunikasi bagi guru dan murid.  Namun ada pengaruh negatifnya juga yaitu merusak tatanan Bahasa Indonesia.
PENGARUH MEDIA AUDIO VISUAL TERHADAP HASIL BELAJAR PESERTA DIDIK KELAS VII SMP YPS SINGKOLE SOROWAKO
Authors: Ramlawati Ramlawati , Attahira Nabila , Samputri Salma
Published: April 2024

Penelitian ini bertujuan untuk mengetahui 1) besar peningkatan hasil belajar IPA peserta didik yang diajar dengan media audio visual, 2) besar peningkatan hasil belajar IPA peserta didik yang diajar dengan media gambar, dan 3) perbedaan hasil belajar IPA antara peserta didik yang diajarkan dengan media audio visual dan peserta didik yang diajarkan dengan menggunakan media gambar. Jenis penelitian ini adalah penelitian quasi experiment dengan Nonequivalent Control Group Design dengan Populasi seluruh peserta didik kelas VII SMP YPS Singkole yang terdiri dari 6 kelas dengan jumlah peserta didik sebanyak 191 orang. Pemilihan sampel secara purposive sampling yaitu kelas eksperimen 32 orang dan kelas kontrol 32 orang. Hasil analisis deskriptif hasil belajar peserta didik diperoleh skor rerata pada kelas eksperimen 18,34 dan kelas kontrol 14,69. Sedangkan tingkat hasil belajar peserta didik diperoleh skor rerata pada kelas eksperimen 0,47 kategori sedang dan kelas kontrol 0,30 tergolong kategori sedang. Berdasarkan hasil analisis inferensial menggunakan uji-t hasil belajar di peroleh 𝑡ℎ𝑖𝑡𝑢𝑛𝑔 = 16,47 < 𝑡𝑡𝑎𝑏𝑒𝑙 = 1,66, pada taraf signifikan (α) = 0,05. Dengan demikian H0 ditolak sedangkan H1 diterima dan disimpulkan bahwa terdapat pengaruh media audio visual terhadap hasil belajar peserta didik SMP YPS Singkole Sorowako pada pokok bahasan sistem tata surya.
PENGEMBANGAN BAHAN AJAR DASAR-DASAR PENDIDIKAN MIPA BERBASIS GOOGLE BOOKS
Authors: Rohmadi Mukhlis , Septiana Nurul
Published: April 2024

Google books merupakan platform atau aplikasi yang dapat digunakan untuk bahan bacaan berupa buku dan sejenisnya. Untuk menunjang dan mempermudah bahan bacaan mahasiswa dalam perkuliahan Dasar-Dasar Pendidikan MIPA di IAIN Palangka Raya maka dikembangkan bahan ajar berbasis Google books. Pengembangan bahan ajar yang dilakukan dengan 4D, yaitu Define, Design, Development serta Disseminate. Bahan ajar yang dikembangkan berbentuk buku dan memberikan hasil bahan ajar yang menarik, mudah dibaca dan digunakan serta tidak memberikan beban tambahan pada gawai yang digunakan. Serta bahan ajar yang digunakan mampu digunakan dengan berbagai platform sistem informasi, mulai dari Android, iOS, Windows, MacOS hingga linux. Mahasiswa menjadi terbantu dan mudah dalam proses perkuliahan Dasar-Dasar Pendidikan MIPA dengan bahan ajar yang dikembangkan. Hasil validasi menunjukkan bahwa bahan ajar yang dikembangkan Sangat baik dan Layak untuk digunakan.
Revitalizing Women`s Success: The Power of Leadership, Training, and Innovation for Entrepreneurs in Indonesia
Authors: Pertiwi Diva Intan , Hikmah Nisa Nurul , Harianja Veronika Gabriella , Rohman Abdul
Published: April 2024

Objective - This research was motivated by data from the Indonesian Entrepreneurs Association (IWAPI), which revealed a significant majority of small and medium-sized entrepreneurs (98%) among its 30,000 members.
Methodology/Technique – Previous studies on women entrepreneurs' performance had limitations regarding variables and sectors. Therefore, this study analyzed various factors and sectors that impacted women entrepreneurs in the Jabodetabek (Jakarta, Bogor, Depok, Tangerang, Bekasi) region.
Finding – This study invented novelty, including new knowledge related to variables that affect women entrepreneur performance, especially in the MSMEs sector with a wider area. This study was quantitative research with 246 respondents and was analyzed using SmartPLS Software. The results found that while leadership had some influence on innovative work behavior and women entrepreneurs' performance, the significance was limited.
Novelty – Additionally, training and development significantly impacted both innovative work behavior and women entrepreneurs' performance, with the latter being mediated by the former. Ultimately, innovative work behavior significantly influenced women entrepreneurs' performance.

Type of Paper: Empirical
JEL Classification: D83, D89.
Keywords: Entrepreneurs, Women Entrepreneurs, Leadership, Training and Development, Innovative Work Behavior.
Reference to this paper should be referred to as follows: Pertiwi, D. I; Hikmah, N.N; Harianja, V.G; Rohman, A. (2024). Revitalizing Women`s Success: The Power of Leadership, Training, and Innovation for Entrepreneurs in Indonesia, GATR-Global J. Bus. Soc. Sci. Review, 12(1), 25–33. https://doi.org/10.35609/gjbssr.2024.12.1(3)