bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparación de los resultados del Exani-II con el desempeño de los estudiantes cinco años después.
Authors: Torres Soto A. , Torres Soto M.D. , Ponce de León E.E.
Published: March 2022

En este trabajo se reportan los hallazgos del análisis de un grupo de 46 estudiantes, transcurridos cinco años de la presentación de la evaluación estandarizada EXANI-II aplicada en la ciudad de Aguascalientes en el año 2013. Inicialmente se agrupó a los jóvenes en una de tres categorías de acuerdo a su situación académica actual (alumno regular, alumno rezagado o alumno desertor). Posteriormente se analizaron los resultados que cada uno de los jóvenes obtuvo con la intención de establecer si existe relación entre los resultados obtenidos en las diferentes áreas del examen y su situación académica actual. Una vez realizadas las pruebas estadísticas se encontró que a pesar de que parecía existir cierta relación entre los resultados de matemáticas y español con la situación actual, no existe evidencia estadística que respalde esta hipótesis; así es que los resultados del Exani-II, no poseen poder de predicción a largo plazo.

In this paper, we report the findings of the analysis of a group of 46 students, five years after the presentation of the standardized evaluation EXANI-II applied in the city of Aguascalientes in 2013. Initially youths were grouped in three ranks according to their current academic situation (regular student, irregular student or deserter student). Subsequently the results those students obtained of EXANI-II were analyzed looking for relationship with their current academic situation. Once statistical tests were performed, it was found that even though was a relationship between math and Spanish results with the current academic situation, there is not statistical evidence to suggest that; so, Exani-II results have not power of long-term prediction.
Giant adrenal myelolipoma treated by laparoscopic excision: A case report and review of literature
Authors: Reddy Pogula Veda Murthy , Galeti Ershad Hussain , Thakare Kashinath Vasanth , Velivela Venkatesh , Reddy Sandeep , Verma Abhiram , Galeti Ayesha
Published: March 2022

Adrenal myelolipoma is inevitably a benign neoplasm of the adrenal gland. It is the second most common primary adrenal incidentaloma after adrenocortical adenomas. Adrenal myelolipoma is a rare, benign and non-functional neoplasm, composed of mature adipose and hematopoietic tissue which closely resembles bone marrow. Most of these lesions are small, unilateral and asymptomatic, discovered incidentally at autopsy or on imaging studies performed for other reasons. We report a case of this rare tumour in a 46-year-old obese male who had presented with vague abdominal pain on the right side past 6 months without any other significant history. Ultrasound and subsequently CECT scan abdomen showed a large well-circumscribed mass arising from the right adrenal gland, measuring 11×10cm. Laparoscopic right adrenalectomy was performed.
PENETAPATAN KADAR BETA KAROTEN PADA KULIT BUAH NAGA MERAH DAN KULIT BUAH NAGA PUTIH DENGAN MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-VIS
Authors: Winahyu Diah Astika , Ulfa Ade Maria , Lestari Risqi Indri
Published: March 2022

Buah naga merah terkenal sebagai salah satu sumber beta karoten yang sangat berguna sebagai pengganti antioksidan, meningkatkan sistem imun dan mengobati berbagai penyakit. Penelitian ini bertujuan untuk mengetahuikadar beta karoten pada kulit buah naga merah dan kulit buah naga putih dengan menggunakan metode spektrofotometri UV-Vis. Ekstraksi senyawa beta karoten dari kulit buah naga dilakukan dengan menggunakan petroleum eter kemudian di sentrifuge selama 5 menit. Setelah itu ditambahkan natrium sulfat anhidrat dan dibekukan selama 24 jam.Setelah dilakukan analisis senyawa beta karoten dengan menggunakan spektrofotometri UV-Vis. Hasil dari penelitian menunjukkan bahwa ekstrak kulit buah naga mengandung senyawa beta karoten. Berdasarkan hasil analisis spektrofotometri UV-Vis, pada panjang gelombang maksimum sebesar 451 nm, kulit buah naga merah memiliki kadar rata-rata beta karoten sebesar 0,015%dan kulit buah naga putih memiliki kadar rata-rata beta karoten sebesar 0,027%. Hasil ini sesuai dengan Ha dimana kadar beta karoten pada kulit buah naga merah lebih besar daripada kulit buah naga putih.Kata kunci :kulit buah naga, beta karoten, spektrofotometri UV-Vis
Diversity, equity and inclusion policy texts in Canadian agriculture
Authors: Cameron Dr. Bobby Thomas , Ghaith Dr. Ziad , Chilton Dr. Lisa
Published: March 2022

This study explores diversity, equity and inclusion (DEI) policy texts in Canadian agriculture from a policy-as-information perspective. Public policy is a powerful form of information in shaping citizenship behaviour and identity. Borrowing theory from social constructionism and using “policy texts” as data, this article enables us to start to understand the discursive framework constructing under-represented groups in agriculture. The article finds that there is a patchwork quilt approach with DEI agricultural policy in Canada: Federal, provincial and territorial governments and non-governmental organizations are individually pursuing DEI agendas. The conclusion calls for future information research on DEI agricultural policy in Canada, with contributions from academics, practitioners, industry and farmers. The contribution of this article is twofold: It provides policy practitioners with a snapshot of current DEI policies in agriculture across Canada and it attempts to stimulate research and discussion among policy scholars through suggestions for future research.
The effect of static passive stretching on a bench press, in one maximum repetition test performance, is independent of the level of flexibility
Authors: Lima Vanessa Da Silva , Iara Diniz Iara Bezerra , Lopes Jonathan Moreira
Published: March 2022

Objective: The aim of this study was to investigate at different levels of flexibility the influence of static passive stretching on bench press one maximum repetition test.

Method: Eleven men (26.09 ± 4.2 years, 81.69 ± 13.94 kg, 1.70 ± 0.05 m) were evaluated in flexibility using Flexitest and goniometry test classified according to their flexibility levels (small and upper middle levels) and joint range of motion (deficit levels), as well as performed the one maximum repetition test in the following experimental protocols: without previous stretching and with stretching 10, 20 and 60 seconds before the test.

Results: The results indicate that 64% demonstrated a low level of flexibility and 36% with a higher average level. In both, there was no significant difference in load: A0s (72.43 ± 21.10Kg vs 66.25 ± 19.02Kg); A10s (72.29 ± 20.25Kg vs 67.25 ± 20.35Kg); A20s (73.43 ± 20.78Kg vs 67.75 ± 18.23Kg) and A60s (73.29 ± 19.35Kg vs 68 ± 19.25Kg). ANOVA for repeated measures showed that no significantly different the maximum strength between groups the protocols of static passive stretching tested.

Conclusion: It was concluded that passive static stretching times lower than 60 seconds, in accordance with the current recommendations, do not interfere in the neuromuscular performance of men in the one maximum repetition test, in the bench press independent of their level of flexibility.
Nível de atividade física entre usuários de substâncias psicoativas
Authors: Matias Guilherme Henrique de Lima , Fonseca Rômulo Maia Carlos
Published: March 2022

Objetivo: Este estudo verificou o nível de atividade física entre usuários de substâncias psicoativas.

Método: Estudo transversal, realizado nos Centros de Atenção Psicossocial Álcool e Outras Drogas do município de Recife (Brasil). Participaram 160 indivíduos com idade 44.09±12.46 anos. Os participantes foram entrevistados por meio do questionário Global physical active questionnaire. Foi aplicado o teste Qui-quadrado de independência para verificar associação entre nível de atividade física e tipo de substância psicoativa utilizada, nível de instrução, raça/cor, sexo e tipo de moradia sendo aceito um p<0.05 como significativo.

Resultados: Os resultados mostraram que 51.9% dos usuários de substâncias psicoativas são fisicamente inativos. Houve associação nos domínios raça/cor da pele (p=0.039) e nível de instrução (p=0.002) com relação ao nível de atividade física.

Conclusão: A partir destes dados será possível estabelecer os grupos que necessitam de maior apoio para promover estímulo à prática de exercício físico.
II Congreso Internacional en Tecnología en la Actividad Física y el Deporte. TAPAS 2021. 22-23 Noviembre 2021
Authors: Caraballo Israel , Gómez-Chacón Ramón , Del Castillo Andrés Oscar
Published: March 2022

Monográfico sobre el uso de la tecnología en la Actividad Física y el Deporte, vinculado al II International VIRTUAL Conference on Technology in Physical Activity and Sport. TAPAS 2021. 22th-25th November 2021, en Sevilla, España. Se han seleccionado los mejores trabajos de investigación presentados en el Congreso, y se ha realizado una revisión ciega por pares para garantizar la calidad de los mismos. Todos ellos versan sobre la tecnología en el ámbito de la gestión deportiva, la salud, la educación y el alto rendimiento en el deporte.
Partido Acción Democrática (AD) y la democracia en Venezuela. Un análisis histórico a ochenta años de la fundación de AD
Authors:   Grupo de Investigaciones Sobre Estudios del Desarrollo y Democracia (GISEDD), Universidad de los Andes, Venezuela, Delgado Rafael ,   rafaelgustavomd@hotmail.com, Valera Alberto ,   Estudios Generales, Universidad Simón Bolívar, Venezuela; albertohoyos@gmail.com
Published: March 2022

Political parties are the political institutions par excellence and the existence of parties and effective party systems are the result of guarantees of fundamental rights of democracy. Therefore, the aim of this research is to analyze the co-origin and interdependence between Democratic Action and democracy in Venezuela. The methodology used is historical-analytical since the inductive tracing of broad contexts and the sequential decomposition of the dense historical narrative allows us to infer the key events and their causal configurations with a greater explanatory weight. The article states that Democratic Action, its internal relations and with other actors, is a fundamental variable to understand the origin, rise, decline and breakdown of democracy in Venezuela. Keywords: Democracy; Acción Democrática; Venezuela; Historical-analytical; Rómulo Betancourt
O Regresso das Ditaduras?
Authors:   Instituto Superior de Ciências Sociais e Políticas da Universidade de Lisboa, Portugal, Rosa Margarida
Published: March 2022

Pinto, A. C. (2021). O Regresso das Ditaduras? Lisboa: Fundação Francisco Manuel dos Santos
Da Guerra e da Pandemia: Estratégia Aplicada para Desmistificar Comparações
Authors:   Departamento de Estudos Políticos, NOVA-FCSH, Portugal, Correia Carolina ,   carolinacorreia53@gmail.com
Published: March 2022

Within the pandemic scenario, political discourse, relying on resemblances amidst pandemic and war exceptionalities, is full of comparisons between the pandemic and wartime, and between the vaccine race and the arms race. Those, more than alarming, act as a tool to justify the sovereign’s exceptionality in the internal realm and intensify the hostility in the external. On the one hand, in the national sphere, these analogies may induce unnecessary irrational panic since the state of exception serves itself as a justification. On the other hand, in the international sphere, even if the pandemic exceptionality doesn’t generate a hostile conflict, strategy, as conflict’s ethics, should keep an open eye whenever the COVID-19 pandemic serves to promote a war language, which associated with the categorization of the otherness, might lead to actions that reveal an intensification of the hostility, like in the Chinese-American relation. Keywords: covid-19; pandemic; strategy; war
Sequência de Políticas Sociais na América Latina: Um Exercício Exploratório entre o Brasil e o Uruguai
Authors:   Observatório Político, Portugal, Bernardes Bruno ,   goncalvesbernardes@gmail.com
Published: March 2022

The study of social policies in Latin America has analyzed the institutional continuity-discontinuity process along the political-economic changes between models of international insertion. In this article, we examine the applicability of historical institutionalist analysis as a tool to understand the social sector policy sequence format in the Brazilian and Uruguayan cases between its beginnings and the 2010s. Keywords: social policies; Latin America; policy sequence; Brazil; Uruguay
BILINGUALISM OR TRICODALISM: UKRAINIAN, RUSSIAN AND «SURŽYK» IN UKRAINE (analysis and linguistic-geographical mapping)
Authors:   University of Oldenburg (Slavic department) Oldenburg, Germany, HENTSCHEL G. , TARANENKO O.O. ,   O. О. Potebnia Institute of Linguistics of the National Academy of Sciences of Ukraine
Published: March 2022

The study aims to show that the different usage frequencies of Ukrainian, Russian and «Suržyk» in everyday life in Ukraine can be described and mapped as a continuum of «tricodalism». This sets it apart from previous representations that usually assume a historical-political demarcation of sub-areas and consequently tend to indicate a linguistic bisection of the country into a Ukrainian-speaking area encompassing the west and the central region, and a Russian-speaking area in the east and south. The approach proposed here employs empirical data on usage of the three codes as the basis for its structuration. Starting from the mean frequencies of code usage in individual oblasts, a cluster analysis groups these into larger areas and clarifies their internal variation. This result is not just a more continuous picture of the linguistic landscape in Ukraine, but also a more coherent one.
PROPER NAMES AS A NATURAL CATEGORY: PROVERBIAL PHRASES WITH CULTURAL NAMES FROM THE PERSPECTIVE OF EPONYMY RESEARCH
Authors:   O.O.Potebnia Institute of linguistics, National Academy of Sciences of Ukraine Kyiv, Ukraine, YERMOLENKO S.S.
Published: March 2022

The paper discusses proverbial collocations with names (e.g., English the sword of Damocles) as a possible object of research on eponymy. The author differentiates these collocations from phrasal eponyms that are scientific and technical terms (e.g. Achilles tendon) or composite proper names (e.g., Ukrainian бульвар Шевченка), in that they are derived semantically from phrases initially found in cultural texts, essentially in the same way antonomastic eponyms are semantically derived from underlying proper names. In both cases a cultural name operates as a key constituent of inner form, expressing some general meaning conveyed by cultural texts in which such names originally appeared and with which they came to be associated. Employing modern approaches to categorization in logic, mathematics, cognitive psychology, and linguistics, he argues that proper names, too, should be considered a natural rather than strictly logical category. In his opinion, collocations with cultural names, along with some other classes of linguistic items, should be considered the periphery of the category of proper names that should be taken into account in eponymy research. With these collocations, as with antonomastic eponyms, an underlying proper name determines not only their generalized cultural sense, but also the way this sense is expressed by referring to the unique object or person operating as its symbol. The importance of including these collocations to the proper name category’s periphery transcends the establishing of their systemic status, since cultural names in them, like those from which antonomastic eponyms are derived, are a major asset for socio- and linguistic-cultural studies, highlighting key concepts of a society’s culture as well as their origins and evolution.
Faktor yang Mempengaruhi Keberhasilan Pengobatan Orang Dengan Gangguan Jiwa (ODGJ)
Authors: Oktaviana Meli , Ratnawati Riska
Published: March 2022

Gangguan jiwa merupakan penyakit kronis yang membutuhkan proses panjang dalam penyembuhannya. Berdasarkan data daftar peserta ODGJ Desa Sukosari dari 28 pasien terdapat 6 orang yang sembuh. Artinya tingkat kesembuhan ODGJ di Desa Sukosari adalah 21%. Sedangkan target dari Puskesmas Sukosari mengenai ODGJ yang minum obat yaitu 90%. Penelitian ini bertujuan untuk mendeskripsikan terkait ekonomi keluarga, dukungan keluarga dan dukungan petugas kesehatan yang dapat mempengaruhi keberhasilan pengobatan ODGJ. Metode yang digunakan dalam penelitian ini adalah kualitatif. Penentuan subjek penelitian berdasarkan teknik  Purposive dengan jumlah subjek penelitian sebanyak 6 keluarga. Pengumpulan data melalui wawancara mendalam dan dokumentasi. Hasil penelitian didapatkan bahwa mayoritas keluarga memberikan dukungan berupa dukungan secara emosional (empati dan peduli),  instrumental (bantuan biaya, bantuan jasa, bantuan waktu) dan pemantauan minum obat kepada anggota keluarga yang mengalami gangguan jiwa. Mayoritas keluarga mendapatkan dukungan dari petugas kesehatan meliputi kunjungan rutin untuk dilakukan penyuntikan dan pemberian obat, serta pemantauan kepada pasien. Kesimpulan  dalam penelitian ini yaitu adanya dukungan keluarga dan dukungan petugas kesehatan kepada ODGJ dapat memberikan dampak positif yang ditunjukkan dengan adanya keberhasilan pengobatan sehingga ODGJ mencapai tingkat kesembuhan. Dari penelitian ini, saran yang disampaikan adalah penelitian ini dapat dijadikan sebagai referensi peneliti selanjutnya untuk lebih mengembangkan penelitian ini.
Systematic Review : Efektivitas Telemedicine pada Pelayanan Antenatal di Masa Pandemi COVID-19
Authors: Martiraz Yundri , Wibowo Adik , Fauzia Amelia
Published: March 2022

Ibu hamil adalah salah satu kelompok yang rentan terinfeksi virus SARS COV-2. Telemedicine manjadi salah satu alternatif solusi yang dapat diimplementasikan bagi ibu hamil yang akan melakukan pemeriksaan antenatal selama masa pandemi berlangsung. Telemedicine dapat menghilangkan proses tatap muka antara wanita hamil dengan dokter, ataupun dengan lingkungan rumah sakit. Tujuan dari penulisan ini adalah untuk mengetahui efektivitas dari telemedicine bagi wanita hamil yang melakukan pemeriksaan antenatal. Systematic review adalah penelusuran artikel dengan metode Preferred Reporting Items for Systematic Reviews (PRISMA) dengan mengakses empat online database (Scopus, Proquest, Pubmed, dan Science Direct), dengan mengumpulkan data pada tahun 2020 sampai dengan tahun 2021. Setelahnya penulis melakukan ekstraksi data dan bias appraisal. Dengan total artikel yang ditemukan dan telah dipilih sebanyak enam artikel, yang terdiri dari tiga studi potong lintang, satu kohort, satu uji kontrol teracak, dan satu metode campuran. Mayoritas hasil dari keseluruhan studi ini dikatakan tidak hanya kepuasan pasien dengan menggunakan telemedicine bagi pasien maupun providers (tenaga kesehatan), tetapi efisiensi pada waktu dan biaya menjadi luaran tambahan yang baik. Kesimpulan dari studi ini adalah telemedicine sangat mampu memberikan keuntungan dan efektivitas yang baik dalam pelayanan antenatal selama masa pandemic COVID-19.
SPECIFICITY OF EMPLOYEES’ CAREER ORIENTATIONS AND CREATIVITY IN A MODERN COMPANY
Authors: Litvinova Anna , Chursin Sergey
Published: March 2022

The study examines a career notion from the point of view of a personality development in professional activity. Particular attention is paid to career orientations as stable personality formations defining on one hand methods of control, stabilization and integration of an individual's career, and on the other hand, the way to professional self-development and personal growth. Correlations are analyzed between career orientations and motivation, and creativity of employees of an architectural design company (N = 21), realizing creative and regulated activity. Necessity to apply tests in order to identify career orientations, a person’s motivation to achieve success, avoid failure, the personal, verbal and non-verbal creativity of the personality is reasoned in the empirical study. Obtained data state importance of creativity for the realization of a personal career depending on a type of professional activity. The results obtained during the research became a basis for the elaboration and implementation of programs for the development of a career and creative potential of the employees.
Key words: avoid failure, career orientations, creative activity, creative personality, creativity, verbal and non-verbal creativity.
INHIBITION TRAINING AS ONE OF BASIC FACTORS OF THE COMING INTO BEING OF THE PERSON
Authors: Shulgina Galina I.
Published: March 2022

On the basis of systematization of a number of ideas of philosophers, physiologists, ethologists and the actual material about violation at people of instincts, by origin the general at us with animals, owing to incorrect understanding of freedom as permissivenesses, excessive development of consumption, a hypertrophy of feeling of a property, and also about weakening of will to overcoming of adversity of life, the conclusion about need of training of inhibition in the course of formation of the identity of the person is made. Briefly, referring to the detailed scientific publications, the actual material about neurophysiological ensuring inhibition of behavior during training by means of increase of reactivity of inhibitory systems, local and all-brain, and about positive influence on this process of an agonist of receptors of an inhibitory neuromediator (gamma aminobutiric acids - GABA) – phenibut is stated. It is supposed that these data can be useful to the correct organization of education and for prophylaxis and correction of deviant behavior.
Key words: deviant behavior, inhibition training, personality.
Su Manshu's Adaptation of Les Misérables: The Manipulation of a Bridging Text in an Activist Translation
Authors: Li Li
Published: March 2022

The past two decades have seen a growing ‘activist’ turn in Translation Studies, whereby the translator is not considered a subservient mediator of the source text, but rather an engaged agent whose translation activity promotes particular political and social ends. The translation and adaptation into Chinese of an English version of Victor Hugo's Les Misérables in 1903 by a Buddhist monk, Su Manshu, illustrates the complex range of social and cultural factors that must be taken into account when considering a text of activist translation. Su Manshu radically edited a portion of Charles E. Wilbour's English translation of Hugo's novel, freely adding new elements, for serialization in a Chinese revolutionary newspaper. The present article traces the nature and impact of the changes made to the English bridging text by Su Manshu in the process of creating a polemical adaptation that would reframe Hugo's representation of the volatile events leading to the 1832 Paris Uprising as a work designed to encourage a contemporary Chinese audience to rise up against its rulers.
Media Sosial untuk Penguatan Fungsi Pelayanan
Authors: Wahyudi Muhammad Imam , Ilham Teguh
Published: March 2022

Pandemi Covid-19 memaksa perubahan terjadi dalam waktu cepat, tidak terkecuali pada aspek layanan publik. Kondisi saat ini menyebabkan masyarakat kesulitan dalam mendapatkan layanan, salah satunya dari kelurahan. Kegiatan pengabdian ini bertujuan untuk memberikan pelatihan kepada perangkat kelurahan dan masyarakat untuk mengoptimalkan media sosial dalam memberikan layanan administratif dan menerima saran, kritik, atau aduan. Kegiatan pendampingan ini dilakukan melalui pertemuan tatap muka terbatas di kantor Kelurahan Madatte dan rumah warga dengan memperhatikan protokol Covid-19. Kegiatan pelatihan ini menghasilkan respons positif dari semua responden, baik dari petugas layanan dan masyarakat pengguna di mana berbagai layanan informasi dapat diakses melalui akun WhatsApp dan informasi dari Instagram resmi Kelurahan Madatte. Walaupun menu yang tersedia masih terbatas pada ketiga layanan, yaitu: alamat kelurahan, pelayanan administrasi, dan akun sosial media kelurahan, namun diharapkan setelah pelatihan ini, petugas layanan kelurahan mampu mengembangkan sistem ini dengan menambah fitur-fitur lain. Selain itu, inovasi ini diharapkan dapat memantik pemerintah daerah dan nasional untuk memberikan pendampingan teknologi yang lebih maju. Selain itu, anggaran yang representatif juga perlu ditingkatkan agar setiap unit layanan yang sangat dekat dengan masyarakat ini bisa diberikan dengan optimal.
Penguatan Peran Pemerintah Desa Cileles dalam Membangun Usaha Mikro Kecil (UMK)
Authors: Mulyana Mulyana , Nurrahman Agung , Abdurohim Abdurohim
Published: March 2022

Rendahnya peran Pemerintah Desa Cileles dalam mendampingi pelaku UMK menjalankan usahanya menjadi fokus permasalahan yang diangkat dalam kegiatan pengabdian masyarakat. Tujuan dari kegiatan pengabdian masyarakat adalah untuk memperkuat peran dari Pemerintah Desa di Desa Cileles dalammembangun UMK di Desa Cileles. Adapun metode dalam kegiatan pengabdian kepada masyarakat (PKM) antara lain menggunakan metode sosialisasi, penyampaian materi dan dialog terbuka bersama Pemerintah Desa Cileles, anggota Badan Permusyawaratan Desa (BPD), tokoh RT/RW dan masyarakat pelaku UMK di Desa Cileles. Hasil dari kegiatan pengabdian adalah: 1) adanya output berupa penguatan peran Pemerintah Desa Cileles sebagai regulator dan menerbitkan Rancangan Peraturan Desa Cileles tentang Klinik Manajemen UMK Desa “Cileles Sejahtera”; 2) sebagai dinamisator, terwujudlah dialog terbuka antara Akademisi IPDN dengan masyarakat terkait permasalahan UMK; 3) sebagai fasilitator, outputnya adalah tersusunnya inventarisir jenis pelatihan dan manfaatnya yang dapat diselenggarakan oleh Pemerintah Desa Cileles dengan  berkolaborasi dengan Akademisi dan pelaku bisnis; 4) sebagai katalisator dalam membangun UMK di Desa Cileles adalah tersampaikannya informasi usaha oleh Akademisi IPDN kepada pelaku UMK dalam penyampaian materi yang telah dilakukan. Kesimpulan dari kegiatan PKM adalah Pemerintah Desa Cileles dan masyarakat pelaku UMK menyambut baik dan memberikan respons positif terkait didirikannya klinik manajemen UMK di Desa Cileles, sebagai wadah bagi pelaku UMK untuk berkonsultasi dan berinovasi, serta sebagai wadah bagi Pemerintah Desa dalam memperkuat perannya dalam mendampingi pelaksanaan usaha pelaku UMK di Desa Cileles dalam jangka panjang.
ÇOCUKLUK ÇAĞI OLUMSUZ YAŞANTILARIN GEBELİKTE YAKINMALAR VE YAŞAM KALİTESİNE ETKİSİ: KESİTSEL BİR ÇALIŞMA
Authors: ÖZŞAHİN Zeliha , AKSAKAL Zeliha Gülsüm , ERDEM Neslihan , KOLDAŞ Bahar , GÜVEN SANTUR Sinem
Published: March 2022

Araştırmanın amacı, çocukluk çağı olumsuz yaşantıların gebelik sürecindeki yakınmalar ve yaşam kalitesine olan etkisini incelemektir. Kesitsel olarak yürütülen bu araştırma, katılmayı kabul eden ve alınma kriterlerini sağlayan 269 gebe ile tamamlanmıştır. Verilerin toplanmasında, kişisel tanıtım formu, Çocukluk Çağı Olumsuz Yaşantılar Ölçeği ile Gebelikte Yakınmalar ve Yaşam Kalitesine Etkisi Ölçeği kullanılmıştır. Verilerin değerlendirilmesinde, tanımlayıcı istatistiksel yöntemlerin yanı sıra Pearson korelasyonu ve Linear Regresyon yöntemleri kullanılmıştır. Katılımcıların çocukluk çağı olumsuz yaşantılar ölçeğinden aldıkları puan ortalaması 0.88±1.37, gebelikte yakınmaların yaşam kalitesine etkisi ölçeğinden aldıkları puan ortalaması ise 72.60 ± 33.64 olarak tespit edilmiştir. Çocukluk Çağı Olumsuz Yaşantılar Ölçeği ile Gebelikte Yakınmalar ve Yaşam Kalitesine Etkisi Ölçeği’nin puan ortalamaları arasında pozitif yönde istatistiksel olarak anlamlı ilişki bulunmuştur (r=.320; p<0.001). Gebelikte yakınmalar ve yaşam kalitesinin %10.3’ünün çocukluk çağı olumsuz yaşantılarındaki değişimle açıklanabildiği belirlenmiştir. Araştırma sonucunda çocukluk çağı olumsuz yaşantıların gebelikteki sağlığı olumsuz etkilediği ve gebelikteki yakınmalar ve yaşam kalitesine etkisi üzerinde belirleyici olduğu tespit edilmiştir.
Symbiotic and Regenerative Sustainability Frameworks: Moving Towards Circular City Implementation
Authors: Horn Erin , Proksch Gundula
Published: March 2022

Growing in popularity, the circular city framework is at the leading-edge of a larger and older transitional dialogue which envisions regenerative, circular, and symbiotic systems as the future of urban sustainability. The need for more research supporting the implementation of such concepts has been often noted in literature. To help address this gap, this holistic review assesses a range of pertinent sustainability frameworks as a platform to identify actionable strategies which can be leveraged to support and implement circular city goals. This assessment is grounded in a holistic overview of related frameworks across interdisciplinary and scalar domains including circular city, the food-water-energy nexus, circular economy, bioeconomy, industrial symbiosis, regenerative design, and others. Building on these interrelationships, the applied strategies espoused within these publications are synthesized and assessed in the context of circular city implementation. From an initial 250 strategies identified in literature, thirty-four general implementation strategies across six thematic areas are distinguished and discussed, finding strong overlaps in implementation strategies between frameworks, and opportunities to further develop and harness these synergies to advance circular city toward sustainable urban futures.
Pyroptosis-Related lncRNAs for Predicting the Prognosis and Identifying Immune Microenvironment Infiltration in Breast Cancer Lung Metastasis
Authors: Liu Li , Chen Chenxi , Tu Gang , Peng Yang , Shen Meiying , Xu Yingkun , Liu Shengchun
Published: March 2022

Breast cancer (BC) is the second leading cause of death among women and is highly heterogeneous. Three pyroptosis (PR) subtypes were identified in patients with BC from the Cancer Genome Atlas Database (TCGA) cohorts using 20 PR-related regulators, which illustrate a strong association between BC prognosis and PR. Lung metastasis commonly occurs in the advanced stages of BC, resulting in a poor quality of life. Eight differentially expressed (DE) lncRNAs were identified using LASSO–Cox analysis between PR-related and BC lung metastasis. Moreover, a BRCA risk-score (RS) model was established using multivariate Cox regression, which correlated with prognosis in TCGA-BRCA. Clinical characteristics, tumor mutation burden, and tumor immune cell infiltration were extensively investigated between high- and low-RS groups. Similarly, a lower RS implied longer overall survival, greater inflammatory cell infiltration, and better immunotherapeutic response to PD-1 blockers. Our findings provide a foundation for future studies targeting PR and confirme that RS could predict the prognosis of patients with BC.
Microtubule Motor Transport of Organelles in a Specialized Epithelium: The RPE
Authors: Hazim Roni A. , Williams David S.
Published: March 2022

The retinal pigment epithelium (RPE) is a uniquely polarized epithelium that lies adjacent to the photoreceptor cells in the retina, and is essential for photoreceptor function and viability. Two major motile organelles present in the RPE are the melanosomes, which are important for absorbing stray light, and phagosomes that result from the phagocytosis of the distal tips of the photoreceptor cilium, known as the photoreceptor outer segment (POS). These organelles are transported along microtubules, aligned with the apical-basal axis of the RPE. Although they undergo a directional migration, the organelles exhibit bidirectional movements, indicating both kinesin and dynein motor function in their transport. Apical melanosome localization requires dynein; it has been suggested that kinesin contribution might be complex with the involvement of more than one type of kinesin. POS phagosomes undergo bidirectional movements; roles of both plus- and minus-end directed motors appear to be important in the efficient degradation of phagosomes. This function is directly related to retinal health, with defects in motor proteins, or in the association of the phagosomes with the motors, resulting in retinal degenerative pathologies.
Metals Are Integral to Life as We Know It
Authors: Rossetto Daniele , Mansy Sheref S.
Published: March 2022

Investigations of biology and the origins of life regularly focus on the components of the central dogma and thus the elements that compose nucleic acids and peptides. Less attention is given to the inorganic components of a biological cell, which are required for biological polymers to function. The Earth was and continues to be rich in metals, and so investigations of the emergence and evolution of life must account for the role that metal ions play. Evolution is shaped by what is present, and not all elements of the periodic table are equally accessible. The presence of metals, the solubility of their ions, and their intrinsic reactivity all impacted the composition of the cells that emerged. Geological and bioinformatic analyses clearly show that the suite of accessible metal ions changed over the history of the Earth; however, such analyses tend to be interpreted in comparison to average oceanic conditions, which do not represent well the many niche environments present on the Earth. While there is still debate concerning the sequence of events that led to extant biology, what is clear is that life as we know it requires metals, and that past and current metal-dependent events remain, at least partially, imprinted in the chemistry of the cell.
Diagnostic, Prognostic, and Therapeutic Roles of Gut Microbiota in COVID-19: A Comprehensive Systematic Review
Authors: Farsi Yeganeh , Tahvildari Azin , Arbabi Mahta , Vazife Fateme , Sechi Leonardo A. , Shahidi Bonjar Amir Hashem , Jamshidi Parnian , Nasiri Mohammad Javad , Mirsaeidi Mehdi
Published: March 2022

Introduction

The Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) emerged in late December 2019. Considering the important role of gut microbiota in maturation, regulation, and induction of the immune system and subsequent inflammatory processes, it seems that evaluating the composition of gut microbiota in COVID-19 patients compared with healthy individuals may have potential value as a diagnostic and/or prognostic biomarker for the disease. Also, therapeutic interventions affecting gut microbial flora may open new horizons in the treatment of COVID-19 patients and accelerating their recovery.

Methods

A systematic search was conducted for relevant studies published from December 2019 to December 2021 using Pubmed/Medline, Embase, and Scopus. Articles containing the following keywords in titles or abstracts were selected: “SARS-CoV-2” or “COVID-19” or “Coronavirus Disease 19” and “gastrointestinal microbes” or “dysbiosis” or “gut microbiota” or “gut bacteria” or “gut microbes” or “gastrointestinal microbiota”.

Results

Out of 1,668 studies, 22 articles fulfilled the inclusion criteria and a total of 1,255 confirmed COVID-19 patients were examined. All included studies showed a significant association between COVID-19 and gut microbiota dysbiosis. The most alteration in bacterial composition of COVID-19 patients was depletion in genera Ruminococcus, Alistipes, Eubacterium, Bifidobacterium, Faecalibacterium, Roseburia, Fusicathenibacter, and Blautia and enrichment of Eggerthella, Bacteroides, Actinomyces, Clostridium, Streptococcus, Rothia, and Collinsella. Also, some gut microbiome alterations were associated with COVID-19 severity and poor prognosis including the increment of Bacteroides, Parabacteroides, Clostridium, Bifidobacterium, Ruminococcus, Campylobacter, Rothia, Corynebacterium, Megasphaera, Enterococcus, and Aspergillus spp. and the decrement of Roseburia, Eubacterium, Lachnospira, Faecalibacterium, and the Firmicutes/Bacteroidetes ratio.

Conclusion

Our study showed a significant change of gut microbiome composition in COVID-19 patients compared with healthy individuals. This great extent of impact has proposed the gut microbiota as a potential diagnostic, prognostic, and therapeutic strategy for COVID-19. There is much evidence about this issue, and it is expected to be increased in near future.
Greater Phage Genotypic Diversity Constrains Arms-Race Coevolution
Authors: Castledine Meaghan , Sierocinski Pawel , Inglis Mhairi , Kay Suzanne , Hayward Alex , Buckling Angus , Padfield Daniel
Published: March 2022

Antagonistic coevolution between hosts and parasites, the reciprocal evolution of host resistance and parasite infectivity, has important implications in ecology and evolution. The dynamics of coevolution—notably whether host or parasite has an evolutionary advantage—is greatly affected by the relative amount of genetic variation in host resistance and parasite infectivity traits. While studies have manipulated genetic diversity during coevolution, such as by increasing mutation rates, it is unclear how starting genetic diversity affects host–parasite coevolution. Here, we (co)evolved the bacterium Pseudomonas fluorescens SBW25 and two bacteriophage genotypes of its lytic phage SBW25ɸ2 in isolation (one phage genotype) and together (two phage genotypes). Bacterial populations rapidly evolved phage resistance, and phage reciprocally increased their infectivity in response. When phage populations were evolved with bacteria in isolation, bacterial resistance and phage infectivity increased through time, indicative of arms-race coevolution. In contrast, when both phage genotypes were together, bacteria did not increase their resistance in response to increasing phage infectivity. This was likely due to bacteria being unable to evolve resistance to both phage via the same mutations. These results suggest that increasing initial parasite genotypic diversity can give parasites an evolutionary advantage that arrests long-term coevolution. This study has important implications for the applied use of phage in phage therapy and in understanding host–parasite dynamics in broader ecological and evolutionary theory.
An Online Interval-Based Inertial Navigation System for Control Purposes of Autonomous Boats
Authors: Le Bars Fabrice , Sanchez Robin , Jaulin Luc , Rohou Simon , Rauh Andreas
Published: March 2022

Interval analysis is a numerical tool classically used for solving nonlinear equations in a guaranteed way. It has been shown that it can be used to build reliable nonlinear state estimators for dynamical systems. Numerous simulations inspired from real-life applications have shown the applicability of the approach. This paper proposes to implement an interval-based INS (Inertial Navigation System) in an actual robot to estimate its orientation and position. It shows that some types of outliers can be naturally handled by the fusion algorithm, while the resulting controller can be both fast and reliable. Experiments with an actual autonomous boat conclude this article.
Incremental Prognostic Value of Pericoronary Adipose Tissue Thickness Measured Using Cardiac Magnetic Resonance Imaging After Revascularization in Patients With ST-Elevation Myocardial Infarction
Authors: Ma Yue , Ma Quanmei , Wang Xiaonan , Yu Tongtong , Dang Yuxue , Shang Jin , Li Guangxiao , Hou Yang
Published: March 2022

Background and Aim

Pericoronary adipose tissue (PCAT) reflects pericoronary inflammation and is associated with coronary artery disease. We aimed to identify the association between local PCTA thickness using cardiac magnetic resonance (CMR) and prognosis of patients with ST-elevation myocardial infarction (STEMI), and to investigate the incremental prognostic value of PCAT thickness in STEMI after reperfusion.

Methods

A total of 245 patients with STEMI (mean age, 55.61 ± 10.52 years) who underwent CMR imaging within 1 week of percutaneous coronary intervention therapy and 35 matched controls (mean age, 53.89 ± 9.45 years) were enrolled. PCAT thickness indexed to body surface area at five locations, ventricular volume and function, infarct-related parameters, and global strain indices were evaluated using CMR. Associations between PCAT thickness index and 1-year major adverse cardiovascular events (MACE) after STEMI were calculated. The prognostic value of the standard model based on features of clinical and CMR and updated model including PACT thickness index were further assessed.

Results

Patients with MACE had a more significant increase in PCAT thickness index at superior interventricular groove (SIVGi) than patients without MACE. The SIVGi was significantly associated with left ventricular ejection fraction (LVEF), infarct size, and global deformation. SIVGi > 4.98 mm/m2 was an independent predictor of MACE (hazard ratio, 3.2; 95% CI: 1.6–6.38; p < 0.001). The updated model significantly improved the power of prediction and had better discrimination ability than that of the standard model for predicting 1-year MACE (areas under the ROC curve [AUC] = 0.8 [95% CI: 0.74–0.87] vs. AUC = 0.76 [95% CI: 0.68–0.83], p < 0.05; category-free net reclassification index [cfNRI] = 0.38 [95% CI: 0.1–0.53, p = 0.01]; integrated discrimination improvement [IDI] = 0.09 [95% CI: 0.01–0.18, p = 0.02]).

Conclusions

This study demonstrated SIVGi as an independent predictor conferred incremental value over standard model based on clinical and CMR factors in 1-year MACE predictions for STEMI.
Simultaneous Multi-Slice Cardiac MR Multitasking for Motion-Resolved, Non-ECG, Free-Breathing T1–T2 Mapping
Authors: Mao Xianglun , Lee Hsu-Lei , Hu Zhehao , Cao Tianle , Han Fei , Ma Sen , Serry Fardad M. , Fan Zhaoyang , Xie Yibin , Li Debiao , Christodoulou Anthony G.
Published: March 2022

The aim of this study is to simultaneously quantify T1/T2 across three slices of the left-ventricular myocardium without breath-holds or ECG monitoring, all within a 3 min scan. Radial simultaneous multi-slice (SMS) encoding, self-gating, and image reconstruction was incorporated into the cardiovascular magnetic resonance (CMR) Multitasking framework to simultaneously image three short-axis slices. A T2prep-IR FLASH sequence with two flip angles was designed and implemented to allow B1+-robust T1 and T2 mapping. The proposed Multitasking-SMS method was validated in a standardized phantom and 10 healthy volunteers, comparing T1 and T2 measurements and scan-rescan repeatability against corresponding reference methods in one layer of phantom vials and in 16 American Heart Association (AHA) myocardial segments. In phantom, Multitasking-SMS T1/T2 measurements showed substantial correlation (R2> 0.996) and excellent agreement [intraclass correlation coefficients (ICC) ≥ 0.999)] with reference measurements. In healthy volunteers, Multitasking-SMS T1/T2 maps reported similar myocardial T1/T2 values (1,215 ± 91.0/41.5 ± 6.3 ms) to the reference myocardial T1/T2 values (1,239 ± 67.5/42.7 ± 4.1 ms), withP= 0.347 andP= 0.296, respectively. Bland–Altman analyses also demonstrated goodin vivorepeatability in both the multitasking and references, with segment-wise coefficients of variation of 4.7% (multitasking T1), 8.9% (multitasking T2), 2.4% [modified look-locker inversion recovery (MOLLI)], and 4.6% (T2-prep FLASH), respectively. In summary, multitasking-SMS is feasible for free-breathing, non-ECG, myocardial T1/T2 quantification in 16 AHA segments over 3 short-axis slices in 3 min. The method shows the great potential for reducing exam time for quantitative CMR without ECG or breath-holds.
Variation of Thermal Infrared Brightness Temperature Anomalies in the Madoi Earthquake and Associated Earthquakes in the Qinghai-Tibetan Plateau (China)
Authors: Yang Xing , Zhang Tie-bao , Lu Qian , Long Feng , Liang Ming-jian , Wu Wei-wei , Gong Yue , Wei Jia-xi , Wu Jia
Published: March 2022

We processed MODIS data received from ground receiving stations into the spatial range of the Qinghai-Tibetan Plateau (China) and the eastern margin of the plateau, and then 283 K was set as the threshold value to remove the area covered by clouds. The monthly background field was calculated based on 17 years’ data, then we obtained the spatial Brightness Temperature anomaly of the current month by deducting the background field. Furthermore, the Brightness Temperature anomaly curves for secondary tectonic blocks in the plateau were calculated. The data indicated that since June 2020, the Brightness Temperature radiation within the Qinghai-Tibetan Plateau began to increase abnormally, starting from the western part of the study area and expanding eastward to cover the entire plateau. In January 2021, such an anomaly was seen again, extending to the Sichuan-Yunnan Block in the easternmost part of the study area in april. With the ongoing anomaly, a series of moderate and strong earthquakes occurred in the Qinghai-Tibetan Plateau, and finally, on 22 May 2021, the M7.4 earthquake struck the Madoi County. Moreover, according to the internal Brightness Temperature time series curves of the different secondary tectonic blocks, the Brightness Temperature has increased simultaneously since the beginning of 2020. A twofold standard deviation was found in the middle-east segment of the Bayanhar Block and the Qiangtang Block in October 2020, and an almost twofold standard deviation was found in March, while a twofold standard deviation was found in the Sichuan-Yunnan Block in april 2021. The occurrence of earthquakes in the plateau before the Madoi earthquake coincided with an upward trend of the time series curve. The spatial anomaly of Brightness Temperature over the Qinghai-Tibetan Plateau disappeared and the Brightness Temperature time series curve dropped drastically after the Madoi earthquake. The development of spatial anomaly of Brightness Temperature and the time series curve both coincide with the occurrence of earthquakes and are consistent with the generation of tectonic stress in the Qinghai-Tibetan Plateau. Our study showed that thermal infrared Brightness Temperature radiation reasonably reflects regional stress development and enables the detection of anomalies prior to moderate and strong earthquakes.
Climatic and Ecological Changes in the Subtropical High Andes During the Last 4,500 Years
Authors: Mayta Cesar , Maldonado Antonio
Published: March 2022

The effects of climate change may be more evident in mountainous areas. In these areas, an increase in temperature and a decrease in precipitation can reduce the amount of snow, which represents a source of water for human consumption and vegetation. To analyze the effects of climate change on vegetation, it is possible to examine the climate–vegetation relationship in the past and observe the influence of variation in temperature and precipitation on the dynamics of plant communities. The aim of the present work was to describe the climate–vegetation dynamics of the last 4,500 years in the high subtropical Andes of Chile (30°S). The paleoclimatic reconstruction was carried out through the analysis of fossil pollen and macroscopic carbon obtained from sediment cores from two high Andean lakes. The dynamics of the vegetation was analyzed taking into account the alpha and beta diversity. The pollen and carbon records showed three contrasting periods during the last 4,500 years. From the beginning of the sequences until ∼1900 cal. yr BP, relatively dry climatic conditions are suggested, with a slight trend toward more humid conditions after 2,700 cal. yr BP. Pollen records from ∼1900 to ∼600 cal. yr BP suggest wetter conditions than today. Finally, relatively arid conditions have reappeared in the last ∼600 years. The diversity analysis showed that the climate mainly influences the composition of taxa in the communities (beta diversity) and not the richness (alpha diversity). In periods of dry/wet transition and vice versa, beta diversity changes. On the other hand, richness remains relatively constant throughout the record.