bluuebunny/crossref_metadata_2025 huggingface dataset:
Zonificación geotécnica de los suelos de la ciudad de Valledupar mediante utilización de un SIG
Authors: Vanegas-Padilla Angélica Patricia , Palacio-Pacheco Olga Vanessa , Cadena-Carrillo Gustavo , Ortega-Sinning Eberto Rafael
Published: June 2021

Se realizó la zonificación geotécnica de los suelos en la ciudad de Valledupar (cesar) mediante la recolección de datos en diferentes laboratorios de suelos, además de la obtención de muestras por parte de los investigadores. Con dicha información se creó la base de datos necesaria para la investigación. Se obtuvieron gráficos para las diferentes características. Los principales tipos de suelos encontrados fueron SC y SM, así como también suelos GW que se presentan en todas las comunas de la ciudad. El nivel freático se encontró a partir 1,2 metros de profundidad. Desde el punto de vista del RAS, la presente investigación contiene la información necesaria para los estudios previos que dicho reglamento requiere. Se define que la ciudad puede soportar cimientos para edificación de más de 10 niveles siendo las capacidades de carga a los 4 metros superior a los 50 ton/m2, en zonas con altos porcentajes de grava, estas áreas serán las de mayor incidencia a la hora de aumentar la cobertura de redes de acueducto y alcantarillado.

The geotechnical zoning of the soils was carried out in Valledupar (Cesar) by collecting data in various soil laboratories and obtaining samples. The research database was created. The types of soils found were SC, SM and GW identified in all the communes of the city. The water table was found from a depth of 1.2 meters. The document contains the necessary information for geotechnical studies of the area where it is concluded that the city can support building foundations of more than 10 levels, in areas with high percentages of gravel, these areas will be the ones with the highest incidence when increasing coverage of aqueduct and sewerage networks. It is the first geotechnical research study through geographic information models in Valledupar; This indicates the generation of a technical and bibliographic resource for quick consultation
ANALISIS PENELUSURAN MASKER SEBAGAI PROTOKOL KESEHATAN SAAT PANDEMI COVID-19 DI INDONESIA: STUDI GOOGLE TRENDS
Authors: Kusuma Ully Febra , Arsyad Nurunnisa , Lavinia Melissa Shalimar , Rahayu Selvia , Pasaribu Muhammad Khairul Kahfi , Syakurah Rizma Adlia
Published: June 2021

AbstrakMedical masks are also used by people at risk who are indicated to need them. The supply of medical masks is limited, the general public is encouraged to use non-medical masks or cloth masks. This article will discuss the comparison of search results for sensi masks, cloth masks and N-95 masks using google trend analysis. This research method is a qualitative and quantitative study using time series data with quantitative analysis, time-lag correlation is used to assess whether an increase in GT data is correlated with an increase in COVID-19 cases. Data from google trends regarding keywords related to one of the preventive measures for COVID-19, namely masks such as "sensi masks", "cloth masks" and "N-95 masks". Each search interest usually reaches a peak depending on the situation and conditions that occur at that time. The keyword search for "N-95 masks" experienced a peak when 2 Indonesians were confirmed positive for COVID-19, namely on March 2, 2020 and the day after that the keyword "sensi mask" also experienced the highest peak of searches. The keyword search for "cloth masks" peaked on March 6, 2020, when the price of sensi masks began to rise. The results of the keyword correlation test for “sensi mask”, “cloth mask” and “N-95 mask” show that the keyword search results on Google trended a decline in line with the increase in COVID-19 cases in Indonesia. Public interest in tracing increased at the beginning of COVID-19 entering Indonesia. However, the interest in this search continues to decline and is inversely proportional to the increase in the incidence of COVID-19 cases in Indonesia. Keywords:  COVID-19, sensi masks, medical masks, cloth masks, N-95 masks, Google trends
Pengaruh Pengetahuan dan Motivasi Kerja Terhadap Penerapan Early Warning Score System di RSUP H Adam Malik
Authors: Pinem Ita , Zulfendri Zulfendri - , Nasution Siti Saidah
Published: June 2021

ABSTRACTThe national and international scaled-accreditation in a hospital should implement Early Warning Score System (EWSS) as procedure to do early detection of any changing in condition which shows alarm, especially for patients. The data from RSUP H. Adam Malik Medan, revealed that of the 44 medical records, in the inpatiens wards, 46 % of them were are not accordance with the standardized. This research used cross sectional design which was aimed to analyze the influence of knowledge and work motivation on the implementation EWSS. The sample were 89 nurses who worked in the surgery department. The data were analyzed by using multiple linear regression analysis by applying the assumption of multicolliniarity, heteroscedasticity, and normality data. The result showed that the variables of knowledge and work motivation had positive influence on the implementation of EWSS (P-Value 0,00) which indicated that Y model = 0,236 X1+ 0,535 X2 in which Y was EWSS implementation, X1 was knowledge, and X2 was work motivation. The conclusion was that increase in knowledge and work motivation would be followed by the increase in EWSS implementation. It is recommended that the hospital management maximize the implementation of EWSS by increasing the level of knowledge and work motivation. Key Word: Knowledge, Work Motivation, EWSS
‘Insane Thinking’: The Impressionism of Arthur Symons
Authors: Harris Robert
Published: June 2021

This article explores the links between the early verse of Arthur Symons and his definitions of impressionism, particularly as they are outlined in ‘The Decadent Movement in Literature’ (1893). It begins by discussing the ideas of ‘unwholeness’ and insanity in which the essay’s conception of impressionism is grounded, as well as its theoretical underpinnings in the writings of Walter Pater and the artworks of James Abbot McNeill Whistler. The article argues that this theory of impressionism – with its emphasis on the partial and the personal – furnished Symons with a rationale for his lyric experiments of the 1890s and early 1900s, which in turn provided models for some of the most recognisable forms of early modernist poetry. But it also draws attention to a hitherto unacknowledged shift in the manner and matter of Symons’s writings in the years leading up to his nervous breakdown in 1908, when a theory of literary form self-consciously preoccupied with the unstable and the fragmentary, and with the breaking open of rigid or outworn forms, seemed to pull apart under the pressure of its own impulse to fracture. The article concludes by considering the causal link Symons retrospectively drew between his conceptions of impressionism and his experience of mental instability.
Female Onanism: Condemned Pleasures, Medical Probes, and Late-Victorian Pornography
Authors: Rossi Stefano
Published: June 2021

The more Victorian physicians deepened their research into female sexuality, the more a culture of lust infected the hypocritical façade of a nation strictly attached to social norms of order, formality, and bigotry. Lascivious sexual desire and carnal appetite – here embodied in female masturbation – were taboos that had to be forcibly silenced. Yet, late-Victorian pornography mocked medical discourses on female onanism, as well as fears related to female sexuality, and revealed ‘unspeakable’ secret domestic settings marred by ‘dangerous’ practices, scandalous carnality and deviant desires. Furthermore, contemptuous of literary censorship and strict morality, the plenteous erotic literature, represented here by William Lazenby's pornographic magazine The Pearl, not only dared to taunt physicians’ concerns about female ‘self-pollution’ circulating at that time, but also found a great inspiration in the huge domestic success of some innovative medical tools – specifically patented to assuage women's nerves – being produced in those years: electric vibrators. Those ‘engines’ rapidly invaded pornographic literature of the late nineteenth century and became central to a great number of erotic stories, titillating fables and poems, as clearly demonstrated by the contents of The Pearl.
Virginia Woolf's Imaginary Museum of the Medieval in ‘The Journal of Mistress Joan Martyn’
Authors: Marie Caroline
Published: June 2021

This article shows that the Middle Ages Virginia Woolf imagines in her 1906 short story ‘The Journal of Mistress Joan Martyn’ are influenced by the staging of the medieval in late-Victorian museums and reflects late-Victorian medievalism. From the perspective of material culture studies, Woolf's tale reflects the representation and fabrication of the medieval by the British Museum and the South Kensington Museum and shapes a similar narrative of the Middle Ages. Relying on Michel Foucault's definitions of ‘heterotopia’ as well as on Tony Bennett's analysis of Victorian museums, this article argues that Woolf's fictionalisation of the medieval evidences a new, complex temporality of knowledge and consciousness of the past which also defines late-Victorian curatorial philosophy and practices. It analyses each regime of that new temporality: first, the archaeological gaze and its contribution to the grand national narrative via the literary canon and, second, the theatrical gaze, with its focus on spectacularly displayed artefacts, that partakes of an image's mystique. In temporal terms, this results in a tension between the tangible remains of a past clearly separated from the present and the mystical fusion of past and present reinscribing Woolf's poetics of the moment within a sense of history.
Komplikasyon Gelişmiş ve Gelişmemiş Tip II Diabetes Mellitus Hastalarında Paraoksonaz, Arilesteraz, Lipoprotein(a) ve Diğer Lipit Parametreleri Arasındaki İlişki
Authors: ÖZDİN Mehmet , GÜRSU Mehmet Ferit
Published: June 2021

Amaç: Tip II diabetes mellitus (tip II DM) günümüzde çok sık görülmekte olup önemli mortalite nedenleri arasındadır. Bu çalışmadaki amacımız komplikasyon gelişmiş ve gelişmemiş tip II DM hastalarında paraoksonaz1 (PON1), arilesteraz (ARE), lipoprotein(a) [Lp(a)] ve diğer lipit parametreleri arasındaki ilişkiyi belirlemektir.Gereç ve Yöntemler: Fırat Üniversitesi Hastanesi Endokrinoloji kliniğine başvuran 20 komplikasyon gelişmeyen, ve 20 komplikasyon gelişmiş olmak üzere 40 tip II DM hastasının serum PONl, ARE, Lp(a), apo A, apo B ve diğer lipid parametreleri araştırıldı. Kontrol grubu kardiyovasküler hastalığı, diyabeti veya serum lipid düzeyini etkileyen bir hastalığı olmayan sağlıklı 40 bireyden oluşmaktadır. Bulgular: Tip II DM komplikasyon gelişmiş olan hastalarda serum PONl, ARE, total kolesterol, trigliserid, HDL-K, LDL-K, VLDL-K, Lp(a), apo A ve apo B düzeyleri sağlıklı kontrol grubuna göre anlamlı farklılık bulundu (p<0.05). Tip II DM komplikasyon gelişmeyen hastalarında serum HDL-K, LDL-K, Lp(a) ve Apo A düzeyleri sağlıklı kontrol göre anlamlı olarak farklı idi (p<0.05). Ancak serum PONl ve ARE aktiviteleri, total kolesterol, trigliserid, VLDL-K ve apo B düzeyleri sağlıklı kontrol göre anlamlı farklılık gösterdiği saptanmadı (p>0.05). Sonuç: Tip II DM hastalarında PONl, ARE, total kolesterol, trigliserid, HDL-K, LDL-K, VLDL-K, Lp(a), apo A ve apo B bu parametrelerin kontrolünün yapılması komplikasyonların önlenmesini ve hastalığın seyrini olumlu yönde etkileyecektir.
Posterior Uretral Valv Olgularında Ürodinamik İzlem
Authors: YILMAZ Murat , ŞAHİN Ahmet Hikmet
Published: June 2021

Amaç: Posterior uretral valv hastalığı, yenidoğan döneminden itibaren tedavi edilmediği taktirde komplikasyonlara neden olabilen ağır bir patolojidir. Bu çalışmanın amacı,ürodinaminin posterior uretral valvli olguların izlemindeki yeri ve önemini belirlemektir. Gereç ve Yöntemler: Bu retrospektif çalışmada, Ege Üniversitesi, Tıp Fakültesi, Çocuk Cerrahisi A.D’da 1994-2000 yılları arasında tanı, tedavi ve takibi yapılan 34 PUV olgusunun sonuçları değerlendirilmiştir. Bulgular: Bu retrospektif çalışmaya toplam 34 erkek PUV hastası dahil edilmiştir. Olguların tanı anındaki yaş ortalamaları 46±57 (0-158) aydır. Olguların ortalama izlem süreleri 18±14 (En az 1- En çok 56) aydır. Erken dönemde (0-1 yaş) valv ablasyonu uygulanan 8 olgunun ilk ve 1 yaşındaki ikinci ürodinamik incelemelerinde ölçülen mesane kapasiteleri ve kompliyans değerleri ile beklenen mesane kapasiteleri ve kompliyans değerleri arasında istatistiksel olarak anlamlı fark saptanmıştır (p<0.05). Olgulara uygulanan en az iki ürodinamik inceleme sırasında ölçülen işeme basınç değerleri arasında azalma olduğu gözlenmiş ve bu sonuç istatistiksel olarak anlamlı bulunmuştur (p<0.05). Olgulara miksiyosistoüretrografi sonuçlan değerlendirildiğinde üç olguda bilateral, altı olguda tek taraflı VUR (sağ/sol:2/3) saptanmış, 15 olguda VUR saptanmamıştır. Sonuç: Sonuç olarak, posterior uretral valv olgularında valv ablasyonu sonrası tedavi protokolünün belirlenmesi ve izlem açısından; medikal tedavinin etkinliği, detrusorsfınkter ilişkisinin belirlenmesi, basınç- volüm kompliyans gibi parametrelerle matematiksel olarak değerlendirilmesi ve üst üriner traktüs için risk meydana getirebilecek değişikliklerin önceden belirlenebilmesi için ürodinamik izlem etkili bir yöntemdir.
Practice of the key performance indicators application of supreme audit institutions of European countries, the USA and the Accounting Chamber of Ukraine
Authors:   Accounting Chamber of Ukraine, NEVIDOMYI Vasyl , KANONISHENA-KOVALENKO Kateryna ,   Accounting Chamber of Ukraine
Published: June 2021

The international experience of performance indicators application by supreme audit institutions of European countries and the USA in their annual reports is investigated. In total, 267 indicators were identified, analyzed and grouped by areas of activity, in particular, audit activity (audit, conclusions and reports), recommendations, other activities, consequences and effects of work, relations with main stakeholders (with parliament, audit objects, other bodies, society, international community), human resources (personnel, training and certification), management and financial support. The areas of interaction with society and publicity of work, personnel management and audit activity are the most characterized by quantitative indicators areas, least of all interaction with audit objects and other activities of the body, except audit. Among the studied countries, fewer quantitative indicators were published in the reports of the Supreme Audit Institutions of Estonia, Slovakia and Croatia (less than 20 indicators), most of the aspects of activity were quantitatively assessed in the reports of the Supreme Audit Institutions of the UK, Czech Republic and Poland (65 – 80 indicators). The Accounting Chamber in 2020 in terms of the number of indicators in this comparative analysis ranked second (published 75 indicators). Over the eight years analyzed, this number increased significantly, but there is still no indicators for some areas of work, such as international activities and interaction with audited entities. It was also determined that the selection of indicators presented in the reports of the Accounting Chamber lacks consistency, the practice of disclosing some important performance indicators has ceased. Based on the analysis of international practice and the experience of the Accounting Chamber, a system of indicators advisable to characterize its work is proposed. Proposed 55 groups of indicators characterize all areas of activity and correspond to the best international practice and approaches of the supreme audit institutions performance measuring framework (SAI PMF), which is used in the strategic planning of the Accounting Chamber.
Strategic aspects of Ukraine’s cooperation with IFIs in the energy sector
Authors:   SESE “The Academy of Financial Management”, KLYMENKO Kateryna , SAVOSTIANENKO Maksym ,   SESE “The Academy of Financial Management”
Published: June 2021

The article analyzes the cooperation strategies of international financial organizations with Ukraine in terms of priority areas of cooperation in the medium term in the energy sector. The key positions on the directions of reforming the energy sector of Ukraine in line with the requirements of the IMF are studied. The authors study the state of attracting IFIs financial resources in the energy sector of Ukraine. The key areas, tasks, results of attracting financial resources of international financial institutions in the energy sector are identified. Measures are proposed to improve the legislative and regulatory framework in order to increase the effectiveness of further cooperation in the medium term. The conceptual bases of development of the new long-term Strategy of cooperation with IFIs till 2030 are stated. Adoption of the Strategy of Cooperation of Ukraine with International Financial Institutions will coordinate the priority areas of partnership in the medium term and promote the accumulation of resources of international partners, state and local budgets, other sources for development projects in key areas while maintaining acceptable external debt and achieving positive changes in the energy sector. The authors argue that in the current conditions it is advisable to intensify efforts to increase the effectiveness of joint programs in the energy sector. First of all, it is about developing national norms and rules and their harmonization with European ones (taking into account the chosen vector of development) in order to more effectively avoid and manage risks, monitor the processes of preparation, implementation and evaluation of such programs.
Improving public sector entities reporting in terms of transparency of the budget process
Authors:   SESE “The Academy of Financial Management”, KORYTNYK Liliya
Published: June 2021

In the context of the declared state policy on openness and transparency of the budget process, there is a need to improve public sector entities reporting as a key information base on state budget expenditures. Current reporting forms of public sector entities do not reflect information on the types of expenditures (direct and general production), and do not contain information on the cost price of public services financed under the budget program. The article substantiates the expediency of making changes in the forms of financial reporting of public sector entities by disclosure of information on expenditures in terms of direct and general production expenses. This will reflect the use of public financial resources and will establish a relationship between the use of budget funds to pay for public services (direct expenses) or maintenance of institutions (general production expenses). At the same time, it is proposed to supplement forms № 2-ds and № 5-ds with the section “Cost price of sold products, works, services”, which will reveal data on the actual cost price of public services as a key indicator that retransmits public finance management results and their compliance with objectives and expected result of the budget program and state policy in the relevant field. The proposed approach to modernization of disclosure of reporting information will establish methodological integration of conceptual provisions of NP(S)АS 135 “Costs” with forms of financial and budgetary reporting, will promote the implementation of the declared principles of transparency in the budget process, and ensure compliance with the program-target method establishing the relationship between the use of budget funds and performance of public sector entities.
Features of functioning national pension systems of Ukraine and the countries of Eastern Europe
Authors:   SESE “The Academy of Financial Management”, SVIRIDOVSKA Anastasiia
Published: June 2021

An important component of social protection of the population of each country is the pension system, because its efficiency depends on the level of welfare of the population and the level of stability in society. The current pension system does not meet the requirements of today and therefore needs to be revised and reformed. The current demographic situation in Ukraine is characterized by a rapid increase in the number of people of retirement age, which leads to the inefficiency of the solidarity system of the pension fund, the increase in the demographic burden of the tax burden. The result is an insufficient level of pensions for many categories of pensioners. An important task at the present stage of socio-economic transformations in our country is to reform the pension system. After all, raising the level of social security of pensioners and ensuring the sustainable development of the state depend on this reform. Despite the fact that the government has taken a number of important steps in reforming the pension system, today we do not see progress in solving the most acute social problems. Poland’s experience in building its national pension system can be useful for Ukraine in the use of redistributive and funded pension programs, the activities of the main financial institutions of the pension sector, the mechanism for paying pension insurance contributions and the protection of pension assets. Its consideration would contribute to the development of a set of measures and their implementation at the current stage of pension reform in Ukraine.
DIGITAL MODELING OF TREE AND SHRUB VEGETATION OF ACCUMULATIVE SEASHORE BASED ON AIR LASER SCANNING DATA
Authors:   Kuban State University, Boyko Evgeny S. , Karagyan Arsen V. ,   The Southern Branch of the P. P. Shirshov Institute of Oceanology of the Russian Academy of Sciences
Published: June 2021

This article is devoted to the study of tree and shrub vegetation of the Anapa-bay bar, which has a direct impact on the formation of landscape, and affects the processes of accumulation and transfer of matter. The materials of air laser scanning made it possible to perform automated calculation of all trees and shrubs. Their quantitative and qualitative analysis was performed. The study area is divided into sections depending on the nature of the landscape and vegetation. By processing laser scanning data and digital aerial photography, digital models of each tree and shrub above 0.7 m were construct-ed. For the selected areas, the number of all elements and the area of vegetation is calculated up to each tree. As a result, of the study, the method of software selection of tree and shrub vegetation with automatic receipt of attribute information about the height and diameter of vegetation crowns was tested.
GEOINFORMATION SUPPORT FOR FORECASTING FLOOD ZONES IN THE SOUTH OF SAKHALIN
Authors:   Institute of Marine Geology and Geophysics of the Far Eastern branch of the Russian Academy of Sciences, Verhoturov Alexey A. , Melkiy Vyacheslav A. ,   Institute of Marine Geology and Geophysics of the Far Eastern branch of the Russian Academy of Sciences
Published: June 2021

Modern systems of hydrometeorological monitoring, for the most part, widely use WEB and GIS technology tools. Territorial fragmentation divisions of the World Meteorological Organization (WMO), Roshydromet, Russian Academy of Sciences and other services and departments interested in obtaining data requires creation of unified information environment for exchange of heterogeneous information. Formation field for geospatial data has become possible with the availability of industrial design platforms with high performance, supporting standard data exchange formats suitable of system for building projectoin. The purpose of the study is to develop requirements for geoinformation sup-port of the system necessary for flood forecasting. Methods: GIS mapping, interpretation and analysis of remote sensing data of the Earth. When developing system for hydrological monitoring of rivers in the Southern Sakhalin, we used the experience of operating similar observational network in services of several European countries, as well as the geographically distributed GIS created by Roshydromet. Considering the vast experience of predecessors and requirements for geoinformation support neces-sary for predicting flood zones in the rivers of Southern Sakhalin have been developed. The initial da-ta for creating the correct flood model are satellite images, large-scale topographic maps, digital terrain models, data from long-term hydrometeorological observations, and engineering surveys.
EXPERIMENTAL STUDIES OF GEODETIC MONITORING ACCURACY OF UPPER SURFACE OF ENGINEERING OBJECTS AND CONSTRUCTIONS
Authors:   Siberian State University of Geosystems and Technologies, Knol Ivan A.
Published: June 2021

The development of totally new methods for geodetic monitoring of engineering objects and con-structions in emergency state is a relevant scientific and technical task of geodesy. The results of such studies allow to ensure prompt and reliable data of the condition of a spatial object for the purpose of its safe exploitation. The article presents experimental studies of a quadcopter model according to the developed by the author method for geodetic monitoring of engineering objects and constructions based on the multi-agent system theory. The article describes the test model of quadcopter and mean square error calculation of elevation measurement in the laboratory conditions of the station. Based on the experiment results the article makes the conclusion about the possibility of measurement by the described method. The suggested method is possible in situations when measurements by man are im-possible and the object of geo-monitoring is an inaccessible place.
DYNAMICS OF CHANGES IN THE LAND FUND IN THE SYRIAN ARAB REPUBLIC
Authors:   Moscow State University of Geodesy and Cartography (MIIGAiK), Grigoriev Sergey A. , Mohammad Bashar Ali ,   Moscow State University of Geodesy and Cartography (MIIGAiK)
Published: June 2021

This article shows the structure of land in the Syrian Arab Republic (SAR). A system for docu-menting archival data on the state and use of land has been developed. For the first time, the analysis of the Syrian lands condition by categories was performed in the period from 1982 to 2018. Changes in agricultural and non-agricultural land over the previous period were detected. Changes in cultivated agricultural land since 1990 were shown. The distribution of the land fund of Syria by regions was presented. Information was provided about the main legislative acts in the field of land use in Syria. The role of land monitoring in maintaining the real estate cadastre (REC) in Syria was defined. The tasks of information support of the REC were defined. A package of documents for information support of the REC in Syria was proposed. The main infor-mation blocks of databases and banks of land and cadastral data in Syria have been identified. In con-clusion, the importance of using monitoring information in maintaining and updating the real estate cadastre in Syria was marked.
Truncated Estimation of Skating Force-Velocity Profiling When Using High-Speed Video-Based Methods Compared to Radar-Derived Processing
Authors: Perez Jerome , Guilhem Gaël , Brocherie Franck
Published: June 2021

This study aimed to compare the force-velocity mechanical variables derived from high-speed video- and radar-based method during forward skating sprint in ice hockey. Thirteen elite female ice hockey players performed two 40-m forward skating sprints to determine, in the horizontal plane, maximal velocity reached (Vmax), relative maximal theoretical force (F0), maximal theoretical velocity (V0), relative maximal power (Pmax), linear slope of the force-velocity relationship (FV slope), maximal value of the ratio of force (RFmax) and index of force application technique (Drf). Two different high-speed video-based methods adding a time shift (ST-TS) or not (ST) were used and independently compared to the radar-derived method. ST and ST-TS showed significant mean differences (all p < 0.002) compared to radar-derived processing for all variables except for V0 (p = 0.26) and Vmax (p = 0.13) inferred from ST. In reference to radar-derived variables, ST-TS significantly induced larger lower values compared to radar of the main forward skating sprint determinants (Pmax, F0, RFmax and Drf) and moderate-to-large overestimation for velocity variables (V0 and Vmax). Correlations between ST or ST-TS and radar-derived methods ranged from trivial for velocity variables to very large for force and power variables. Consequently, practitioners must be aware that using such high-speed video-based methods would permit to determine mechanical variables at the cost of much lower accuracy and reliability than the radar-derived method.
Whole Transcriptome Analysis Reveals a Potential Regulatory Mechanism of LncRNA-FNIP2/miR-24-3p/FNIP2 Axis in Chicken Adipogenesis
Authors: Guo Lijin , Chao Xiaohuan , Huang Weiling , Li Zhenhui , Luan Kang , Ye Mao , Zhang Siyu , Liu Manqing , Li Hongmei , Luo Wen , Nie Qinghua , Zhang Xiquan , Luo Qingbin
Published: June 2021

Lipid biosynthesis is a complex process, which is regulated by multiple factors including lncRNA. However, the role of lncRNA in chicken abdominal fat accumulation is still unclear. In this research, we collected liver tissues from six high abdominal fat rate Sanhuang broilers and six low abdominal fat rate Sanhuang broilers to perform lncRNA sequencing and small RNA sequencing. A total of 2,265 lncRNAs, 245 miRNAs, and 5,315 mRNAs were differently expressed. Among of them, 1,136 differently expressed genes were enriched in the metabolic process. A total of 36 differently expressed genes, which were considered as differently expressed lncRNAs’ targets, were enriched in the metabolic process. In addition, we also found out that eight differently expressed miRNAs could target 19 differently expressed genes. FNIP2 and PEX5L were shared in a cis-regulatory network and a differently expressed miRNA target relationship network. LncRNA-FNIP2/miR-24-3p/FNIP2 axis was considered as a potential candidate that may participate in lipid synthesis. Experimentally, the objective reality of lncRNA-FNIP2/miR-24-3p/FNIP2 axis was clarified and the regulation effect of lncRNA-FNIP2/miR-24-3p/FNIP2 axis on synthesis was validated. In brief, our study reveals a potential novel regulatory mechanism that lncRNA-FNIP2/miR-24-3p/FNIP2 axis was considered as being involved in lipid synthesis during chicken adipogenesis in liver.
Immunity-Related Gene Signature Identifies Subtypes Benefitting From Adjuvant Chemotherapy or Potentially Responding to PD1/PD-L1 Blockage in Pancreatic Cancer
Authors: Qian Hao , Li Hongzhe , Xie Junjie , Lu Xiongxiong , Li Fanlu , Wang Weishen , Tang Xiaomei , Shi Minmin , Jiang Linxi , Li Hongwei , Chen Hao , Peng Chenghong , Xu Zhiwei , Deng Xiaxing , Shen Baiyong
Published: June 2021

Tumor microenvironment comprises of a variety of cell types, which is quite complex and involved in chemotherapy and immune checkpoint blockage resistance. In order to explore the mechanisms involved in tumor immune microenvironment in pancreatic ductal adenocarcinoma (PDAC), we first constructed an immunity-related 18-gene signature using The Cancer Genome Atlas (TCGA) PDAC project data. Then we applied the 18-gene signature to divide PDAC patients into low score and high score groups. Patients in high score group showed inferior prognosis, which was validated in another four independent cohorts, including Ruijin cohort. High score group showed significant enrichment of pathways involved in cell division and cell cycle especially in G1/S phase transition. In high score group, IHC analysis revealed higher levels of the proliferative indexes of Ki67 and PCNA than that in low score group. Prognostic analysis confirmed that patients in high score group could benefit from the gemcitabine-based adjuvant chemotherapy. In low score group, the programmed cell death 1 ligand 1(PD-L1) (+) cases showed worse prognosis but higher T cell infiltration than PD-L1(−) cases. Our immunity-related 18-gene signature could effectively predict PDAC prognosis, and it might be a practical predictive tool to identify PDAC subtype benefitting from gemcitabine-based adjuvant chemotherapy or potentially responding to PD1/PD-L1 blockade therapy.
Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application
Authors: Prabhu C. P. Keshavananda , Nemakal Manjunatha , Managa Muthumuni , Nyokong Tebello , Koodlur Sannegowda Lokesh
Published: June 2021

N4 macrocyclic complexes of Al and Zn phthalocyanines with symmetrical imine and imidazole moiety at the periphery were synthesized. The synthesized ligands, complexes, and polymers were purified and characterized to study the structure of the molecule. These synthesized complexes were used for photodynamic therapy application as the diamagnetic Zn and Al have the ability to produce and stabilize singlet oxygen species. The synthesized N4 molecules of aluminum iminomethoxy phenyl phthalocyanine and aluminum ethyl phenyl benzimidazolephthalocyanine showed better activity against MCF-7 cells. These results suggest that this assay may be used as an early biomarker of clinical response.
Dynamic Shape Transformation of a DNA Scaffold Applied for an Enzyme Nanocarrier
Authors: Lin Peng , Dinh Huyen , Nakata Eiji , Morii Takashi
Published: June 2021

Structural programmability and accurate addressability of DNA nanostructures are ideal characteristics for the platform of arranging enzymes with the nanoscale precision. In this study, a three-dimensional DNA scaffold was designed to enable a dynamic shape transition from an open plate-like structure to its closed state of a hexagonal prism structure. The two domains in the open state were folded together to transform into the closed state by hybridization of complementary short DNA closing keys at both of the facing edges in over 90% yield. The shape transformation of the DNA scaffold was extensively studied by means of the fluorescence energy transfer measurement, atomic force microscope images, and agarose gel electrophoretic analyses. A dimeric enzyme xylitol dehydrogenase was assembled on the DNA scaffold in its open state in a high-loading yield. The enzyme loaded on the scaffold was subsequently transformed to its closed state by the addition of short DNA closing keys. The enzyme encapsulated in the closed state displayed comparable activity to that in the open state, ensuring that the catalytic activity of the enzyme was well maintained in the DNA nanocarrier. The nanocarrier with efficient encapsulation ability is potentially applicable for drug delivery, biosensing, biocatalytic, and diagnostic tools.
Recent Advances in Cyanine-Based Phototherapy Agents
Authors: Bilici Kubra , Cetin Sultan , Celikbas Eda , Yagci Acar Havva , Kolemen Safacan
Published: June 2021

Phototherapies, in the form of photodynamic therapy (PDT) and photothermal therapy (PTT), are very promising treatment modalities for cancer since they provide locality and turn-on mechanism for toxicity, both of which are critical in reducing off-site toxicity. Irradiation of photosensitive agents demonstrated successful therapeutic outcomes; however, each approach has its limitations and needs to be improved for clinical success. The combination of PTT and PDT may work in a synergistic way to overcome the limitations of each method and indeed improve the treatment efficacy. The development of single photosensitive agents capable of inducing both PDT and PTT is, therefore, extremely advantageous and highly desired. Cyanine dyes are shown to have such potential, hence have been very popular in the recent years. Luminescence of cyanine dyes renders them as phototheranostic molecules, reporting the localization of the photosensitive agent prior to irradiation to induce phototoxicity, hence allowing image-guided phototherapy. In this review, we mainly focus on the cyanine dye–based phototherapy of different cancer cells, concentrating on the advancements achieved in the last ten years.
Progressive Heart Failure and Death as the Initial Manifestation of NK/T-Cell Lymphoma: A Case Report and Literature Review
Authors: Zhang Ziyu , Wang Shuai , Liang Qingchun , Peng Daoquan
Published: June 2021

Natural killer/T-cell (NK/T-cell) lymphoma is a rare-type non-Hodgkin lymphoma derived from NK cells or cytotoxic T cells. Here, we present a case of a 40-year-old woman who experienced quick-developed global heart failure and then was diagnosed with NK/T-cell lymphoma through lymphoid biopsy. Neither transthoracic echocardiography nor any radiological images detected a mass in her heart or pericardium. Elevated plasma troponin level and diffused patchy areas of gadolinium late enhancement on cardiac magnetic resonance were compatible with myocarditis. Considering the persistently elevated cytokine level, systemic inflammation symptoms, acute respiratory distress syndrome, and cardiac dysfunction, a cytokine storm secondary to NK/T-cell lymphoma was considered. Due to the refractory malignant arrhythmia, the patient died soon after being admitted to our hospital.
Prognostic Impact of Metabolic Syndrome in Patients With Heart Failure: A Meta-Analysis of Observational Studies
Authors: Huang Zhuo-Ming , Chen Wen-Rong , Su Qi-Wen , Huang Zhuo-Wen
Published: June 2021

Background: The metabolic syndrome (MS) is significantly associated with the risk of incident heart failure (HF). However, there are still great controversies about the impact of MS on the prognosis in patients with established HF. This meta-analysis aimed to ascertain the effect of MS on the prognosis in patients with HF.

Methods: We searched multiple electronic databases, including PubMed, Opengrey, EMBASE, and Cochran Library, for potential studies up to February 15, 2021. Observational studies that reported the impact of MS on the prognosis in patients with established HF were included for meta-analysis.

Results: Ten studies comprising 18,590 patients with HF were included for meta-analysis. The median follow-up duration of the included studies was 2.4 years. Compared with HF patients without MS, the risk of all-cause mortality and cardiovascular mortality was not increased in HF with MS (HR = 1.04, 95% CI = 0.88–1.23 for all-cause mortality; HR = 1.66, 95% CI = 0.56–4.88 for cardiovascular mortality, respectively). However, there was a significant increase in composited cardiovascular events in the HF patients with MS compared with those without MS (HR = 1.73, 95% CI = 1.23–2.45).

Conclusions: In patients with established HF, the presence of MS did not show an association on the risk of all-cause mortality or cardiovascular mortality, while it may increase the risk of composite cardiovascular events.
Case Report: Left Ventricular Unloading Using a Mechanical CPR Device in a Prolonged Accidental Hypothermic Cardiac Arrest Treated by VA-ECMO – a Novel Approach
Authors: Amacher Simon A. , Quitt Jonas , Hammel Eva , Zenklusen Urs , Darwisch Ayham , Siegemund Martin
Published: June 2021

We recently treated a 36-year-old previously healthy male with a prolonged hypothermic (lowest temperature 22.3°C) cardiac arrest after an alcohol intoxication with a return of spontaneous circulation after 230min of mechanical cardiopulmonary resuscitation and rewarming by veno-arterial ECMO with femoral cannulation and retrograde perfusion of the aortic arch. Despite functional veno-arterial ECMO, we continued mechanical cardiopulmonary resuscitation (Auto Pulse™ device, ZOLL Medical Corporation, Chelmsford, USA) until return of spontaneous circulation to prevent left ventricular distention from persistent ventricular fibrillation. The case was further complicated by extensive trauma caused by mechanical cardiopulmonary resuscitation (multiple rib fractures, significant hemothorax, and a liver laceration requiring massive transfusion), lung failure necessitating a secondary switch to veno-venous ECMO, and acute kidney injury with the need for renal replacement therapy. Shortly after return of spontaneous circulation, the patient was already following commands and could be discharged 3 weeks later without neurologic, cardiac, or renal sequelae and being entirely well. Prolonged accidental hypothermic cardiac arrest might present with excellent outcomes when supported with veno-arterial ECMO. Until return of spontaneous circulation, one might consider continuing with mechanical cardiopulmonary resuscitation in addition to ECMO to allow some left ventricular unloading. However, the clinician should keep in mind that prolonged mechanical cardiopulmonary resuscitation may cause severe injuries.
Flood Risk and River Conservation: Mapping Citizen Perception to Support Sustainable River Management
Authors: Scaini Anna , Stritih Ana , Brouillet Constance , Scaini Chiara
Published: June 2021

Involving citizens in river and flood risk management is critical for risk reduction and sustainable development within river basins, but local community input is often limited. This is partly due to the difficulty of quantifying the perceived values and risks related to the rivers, because these are based on personal knowledge and opinions. There is a need for more data on locals’ opinions and how they are spatially distributed across the river basin. Studies analyzing how perceived risks match evidence-based data can be a first step to including local knowledge in the decision-making process and pose the basis to enhance preparedness. Here, we present a blueprint questionnaire to characterize the perception of flood risk and its spatial distribution across the river basin. Respondents are asked their perception of the role of the river in terms of flood risk and management, as well as to pinpoint on a map the areas they identify as the most dangerous during floods. The approach is tested on the Tagliamento River in the Italian Alps, characterized by debates regarding flood protection, flood management and ecological conservation. The flood risk perception map shows good agreement between perceived risk and existing flood risk assessment maps in the lower basin, where major floods happened in recent memory (1966). In the upper basin, despite having suffered frequent floods, participants are more uncertain about the risks. There is interest in being involved in the risk management debate, and most respondents believe that risk reduction and river conservation are compatible. Land use planning is identified as a factor that can increase flood risk. The results point to the necessity to tackle together conservation, risk management and land use planning in order to develop risk-oriented river management strategies. Our study demonstrates how online participatory mapping can be used to improve the understanding of citizens’ perceptions and expectations with regards to their river, and support participation in sustainable river management.
Numerical Simulation of Ferrofluid Flow in Heterogeneous and Fractured Porous Media Based on Finite Element Method
Authors: Huang Tao , Liao Xin , Huang Zhaoqin , Wang Renyi
Published: June 2021

Ferrofluid is a kind of magnetic fluid, the flow of which is controlled by an external magnetic field. Owing to this property, ferrofluid, as a new function material, has raised extensive concern in the oil industry. In this paper, the issue of ferrofluid flow in complex porous media has been studied by numerical simulation, and the validity and accuracy of the numerical algorithm are demonstrated through a 1-D horizontal tube example. Later, the effects of the magnetic force on ferrofluid flow in complex porous media, such as heterogeneous and fractured porous media, are investigated. The results show that there is basically no flow in low permeability or secondary fracture without a magnetic field, due to the characteristics of porous media and displacement pressure distribution. However, the ferrofluid flow velocity and domain can be changed by applying an external magnetic field. This novel phenomenon may provide a new idea to enhance oil recovery based on controllable flooding technology or meet other industrial needs by using ferrofluid.
Identification of Key Pathways and Genes in Obesity Using Bioinformatics Analysis and Molecular Docking Studies
Authors: Joshi Harish , Vastrad Basavaraj , Joshi Nidhi , Vastrad Chanabasayya , Tengli Anandkumar , Kotturshetti Iranna
Published: June 2021

Obesity is an excess accumulation of body fat. Its progression rate has remained high in recent years. Therefore, the aim of this study was to diagnose important differentially expressed genes (DEGs) associated in its development, which may be used as novel biomarkers or potential therapeutic targets for obesity. The gene expression profile of E-MTAB-6728 was downloaded from the database. After screening DEGs in each ArrayExpress dataset, we further used the robust rank aggregation method to diagnose 876 significant DEGs including 438 up regulated and 438 down regulated genes. Functional enrichment analysis was performed. These DEGs were shown to be significantly enriched in different obesity related pathways and GO functions. Then protein–protein interaction network, target genes - miRNA regulatory network and target genes - TF regulatory network were constructed and analyzed. The module analysis was performed based on the whole PPI network. We finally filtered out STAT3, CORO1C, SERPINH1, MVP, ITGB5, PCM1, SIRT1, EEF1G, PTEN and RPS2 hub genes. Hub genes were validated by ICH analysis, receiver operating curve (ROC) analysis and RT-PCR. Finally a molecular docking study was performed to find small drug molecules. The robust DEGs linked with the development of obesity were screened through the expression profile, and integrated bioinformatics analysis was conducted. Our study provides reliable molecular biomarkers for screening and diagnosis, prognosis as well as novel therapeutic targets for obesity.
Three-Dimensional Genome Interactions Identify Potential Adipocyte Metabolism-Associated Gene STON1 and Immune-Correlated Gene FSHR at the rs13405728 Locus in Polycystic Ovary Syndrome
Authors: Cao Can-hui , Wei Ye , Liu Rang , Lin Xin-ran , Luo Jia-qi , Zhang Qiu-ju , Lin Shou-ren , Geng Lan , Ye Si-kang , Shi Yu , Xia Xi
Published: June 2021

Background

rs13405728 was identified as one of the most prevalent susceptibility loci for polycystic ovary syndrome (PCOS) in Han Chinese and Caucasian women. However, the target genes and potential mechanisms of the rs13405728 locus remain to be determined.

Methods

Three-dimensional (3D) genome interactions from the ovary tissue were characterized via high-through chromosome conformation capture (Hi-C) and Capture Hi-C technologies to identify putative targets at the rs13405728 locus. Combined analyses of eQTL, RNA-Seq, DNase-Seq, ChIP-Seq, and sing-cell sequencing were performed to explore the molecular roles of these target genes in PCOS. PCOS-like mice were applied to verify the expression patterns.

Results

Generally, STON1 and FSHR were identified as potential targets of the rs13405728 locus in 3D genomic interactions with epigenomic regulatory peaks, with STON1 (P=0.0423) and FSHR (P=0.0013) being highly expressed in PCOS patients. STON1 co-expressed genes were associated with metabolic processes (P=0.0008) in adipocytes (P=0.0001), which was validated in the fat tissue (P<0.0001) and ovary (P=0.0035) from fat-diet mice. The immune system process (GO:0002376) was enriched in FSHR co-expressed genes (P=0.0002) and PCOS patients (P=0.0002), with CD4 high expression in PCOS patients (P=0.0316) and PCOS-like models (P=0.0079). Meanwhile, FSHR expression was positively correlated with CD4 expression in PCOS patients (P=0.0252) and PCOS-like models (P=0.0178). Furthermore, androgen receptor (AR) was identified as the common transcription factor for STON1 and FSHR and positively correlated with the expression of STON1 (P=0.039) and FSHR (P=4e-06) in ovary tissues and PCOS-like mice.

Conclusion

Overall, we identified STON1 and FSHR as potential targets for the rs13405728 locus and their roles in the processes of adipocyte metabolism and CD4 immune expression in PCOS, which provides 3D genomic insight into the pathogenesis of PCOS.