bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Hukum Islam terhadap Jual Beli Online
Authors: Al Ghifari Abu Dzar , Juliati Nst Yenni Samri
Published: March 2023

One of the mu'amalah phenomena in the economic field is buying and selling transactions that use electronic media, technological developments have spurred changes in individual habits including one of them in terms of buying and selling transactions. If in the past what was meant by buying and selling transactions had to be carried out face to face where there was a direct transfer of goods from the seller to the buyer, that is the buyer had to meet the seller in the real market. Judging from the type of research, there is also the type of research used in this research, namely bibliography research or library research, which is research that is carried out by collecting information or making objective records that mean the object of research or collecting information that has the character of a bibliography, or analysis carried out to unravel a problem which is basically based on critical and in-depth analysis of relevant literature materials. This research results that in online sales it fulfills the pillars of the contract in accordance with the rules of fiqh. As is well known, there are four pillars of contract, namely: (a); there are contracting parties; (b) consent and acceptance; (c) the object of the contract; (d) the main purpose of the contract is carried out.

Keywords: Hadith, Online Buying and Selling, Islamic Perspective
Implementation of a Problem-Based Learning (PBL) Model Assisted By Zoom Cloud Meeting in Improving High School Students’ Critical Thinking Skills and Learning Motivation on the Concept of Environmental Pollution
Authors: Handayani Nurjanah , Muizz Abdul , Wahidin Wahidin , Nur Sofyan
Published: March 2023

This study aims to determine the effectiveness of the problem-based learning (PBL) model in improving the critical thinking skills and learning motivation of 10th grade senior high school students through the biology-based learning of environmental concepts and pollution, especially water and soil pollution. This study also aims to determine students' responses to the problem-based learning model. A quasi-experiment with a control group before and after the test is used to conduct the research. This research was done over the course of four meetings. The population of this study consists of all 10th-grade senior high school students, with the following characteristics: the first 10th-grade senior high school students are an experimental class implementing PBL with Zoom Cloud Meeting, and the second 10th-grade senior high school students are a control class with a scientific approach learning model. The N-Gain test was used to measure critical thinking skills before and after learning, as well as the level of motivation at the end of learning, to collect data for this study. The findings showed that: 1) The PBL model was implemented successfully, with a score of 95%, using Zoom cloud meetings. 2) When compared to the 5M models, the implementation of learning using the PBL model through Zoom Cloud Meetings improved students' critical thinking skills. The N-Gain test results were within the middle range, precisely 0.51. 3) Using Zoom cloud meetings to apply the PBL approach has no meaningful effect on increasing students' learning motivation. 4) Students were highly enthusiastic about studying the PBL methodology using Zoom cloud sessions
Religious Affairs Office in Providing Prime Services for the Community
Authors: Irama Dodi , Arief Fakrulloh Zudan , Redi Ahmad
Published: March 2023

Marriage according to Law no. 1 of 1974 concerning marriage is an inner and outer bond between a man and a woman to live a happy and eternal household based on Belief in the One and Only God. Marriage is a high honor and respect for the dignity given by Islam specifically for humans. Marriage is a process that must be followed by everyone to preserve offspring. In addition, marriage, as a process of perfecting half of religion, is also carried out as an effort to prevent adultery, to create peace and tranquility for the soul concerned, and peace for the family and society. A qualitative approach was used in this study to know the quality of services provided by the KUA Wonosalam in the registration and registration of marriages to achieve excellent service. The efforts of the Demak City Government to improve marriage management services at the Wonosalam Religious Affairs Office (KUA) are by trying to apply excellent service quality to every officer at the Wonosalam KUA. The Quality of Administrative Services for marriage registration at KUA Eonosalam is based on wholehearted service provided to the community, namely by applying the Tangible, Reliability, and Assurance dimensions in the indicators of infrastructure facilities and guarantees on time because there are still inadequate facilities and there are obstacles that hinder the administrative service process this KUA. Service has been said to be good in the Responsiveness and Empathy dimensions in terms of speed and accuracy of service and ease of good communication. Even though there are still some obstacles, the efforts that have been made are to improve the network they had
Legal Policy on Gambling Crime
Authors: Rimawan Dany , Santiago Faisal , Budianto Azis
Published: March 2023

Gambling is a form of social pathology that poses a real and potential threat to social norms so that it threatens social order. Thus, it will greatly impact on national development with material-spiritual aspects which must therefore be addressed in a rational way. One of these rational efforts is the policy approach to criminal law enforcement regulated in the Criminal Code (KUHP) in accordance with the amendments by Law no. 7 of 1974 concerning the regulation of gambling. However, the policy formulation of laws and regulations has several weaknesses. At the applicative stage, the judge is not free to determine the types of criminal sanctions that will be imposed on the perpetrators of gambling crimes. This is due to the general minimum system and the general maximum system adopted by the Criminal Code, so that any type of criminal sanctions contained in the law must be applied by judges. Policies for dealing with gambling crimes in the future must still be carried out by means of a penalty. Policy formulation of criminal law must be more optimal and able to reach the development of criminal acts of gambling with advanced technology.
Law Enforcement Against Cybercrime in Online Activities
Authors: Hermawati Novi , Santiago Faisal
Published: March 2023

The development of information and communication technology makes the relationship between individuals and groups with the world not limited to existing norms so that it can cause a change in all fields. The changes also have a major impact on the transformation of values in society. It occurs not only positive but also negative consequences. Information and communication technology used for crime is known as cybercrime. Cybercrime has been confirmed to be adverse to the worldwide community, at the same time as efforts to get rid of cybercrime are nevertheless hampered through numerous factors, therefore, a crook regulation coverage is wanted towards cybercrime crimes. This paper discusses two problems, namely, first, how to enforce the law against cybercrime in the legislation in Indonesia, and second, how the strategy for eradicating cybercrime is formulated in the Law on Information and Electronic Transactions. Law enforcement against cybercrime is performed through criminal and non-criminal policies. Meanwhile, to eradicate cybercrime, it is necessary to prepare appropriate laws and provide legal provisions for law enforcement officers.
Law Enforcement Against Cybercrime in Online Activities
Authors: Sutardi Sutardi , Ferdiles Lucky
Published: March 2023

Indonesia, as a country based on law (rechtstaat), is not solely based on mere power (machtstaat), consequently that in the life of society, nation and state it is obligatory to comply with the will that has been regulated based on the applicable laws and regulations. One of the concepts in the theory of the welfare state is that the state has the responsibility to provide maximum health services to its citizens. Based on the provisions of Law Number 36 of 2009 concerning Health, in Article 5 paragraph (1) that; Everyone has the same right in obtaining access to resources in the health sector. One of the health sectors is the hospital which is an important part in the health sector and plays a role in supporting the survival of the community to live a healthy and prosperous life. Hospital medical records are an important component in the implementation of hospital management activities. According to the provisions of the legislation, namely Law Number 29 of 2004 concerning Medical Practice Article 46 paragraphs (1) to (3) and Minister of Health Regulation No. 269 of 2008 concerning Medical Records and Medical Records, made by doctors who are included in the management of their responsibilities which are intended for the condition of the patient. For this reason, medical secrets are the obligation of every doctor to maintain them as required by legislation. The obligation to keep medical secrets concerns things that are obtained through disease examination procedures or by chance, which are carried out by doctors, including those related to the patient's health. The problems that can be raised from this research are; 1. How is the construction of laws and regulations in regulating medical secrets? and, 2. Why does the legality of the disclosure of medical secrets require legal reform through a progressive legal approach? Solving the problem is done through a juridical normative research approach. The results of his research, that medical records are facilities that contain information about patients' illnesses and treatments aimed at maintaining and improving a health service regulated by Law No. 29 of 2004 concerning Medical Practice and Minister of Health Regulation No. 269 of 2008 concerning Medical Records. Legal reform regarding the disclosure of medical secrets through a progressive legal approach, constructively hospitals are obliged to comply with these laws and if violated are threatened with administrative sanctions ranging from verbal warnings, written warnings to license revocation and criminal sanctions
Termination Of Employment Relationship Based On Law Regulation Number 11 Of 2020 Concerning Employment Creation
Authors: Qiram Syahrul , Santiago Faisal
Published: March 2023

The study aims to examine/analyze legal protection for workers/laborers for termination of employment (PHK) due to Force Majeure experienced by the company. The research method used in this proceeding uses normative juridical research methods, namely research that is focused on examining the application of norms or norms in normative law, namely an approach that uses the positivist conception of legis. This concept views law as identical to written norms made and promulgated by authorized institutions or officials. The conception views law as a normative system that is independent, closed, and detached from the real life of society. Based on the research results about Termination of Employment (PHK) due to Force Majuere from the Covid-19 Virus pandemic, many private companies have used it so many have terminated their work relationships so that workers/laborers lose their daily livelihood for themselves and their families. The need for legal protection for the rights of workers/ laborers affected by layoffs is clarified to provide legal certainty. So that there will be no more Termination of Employment experienced by workers/laborers, and also employers take the opportunity to cheat in this situation.
Juridical Review of Criminal Sanctions Against Perpetrators of Intellectual Property Rights Violations
Authors: Dewi Zion Fransisca , Isretno Israhadi Evita , Redi Ahmad
Published: March 2023

Copyright is the exclusive right of the Creator or Copyright Holder to regulate the use of the results of casting specific ideas or information. Copyright applies to various types of works of art or copyrighted works. With the existence of Law Number 28 of 2014 concerning Copyright, it is hoped that it will facilitate proof in copyright disputes, especially in works of art, as well as the originality of ideas, content, and digital products.
Policy Concept for Repatriation of Problematic Indonesian Migrant Workers (TKIB)
Authors: Daniel Daniel , Suparno Suparno
Published: March 2023

The policy for the repatriation of Indonesian workers in certain situations is regulated by Presidential Regulation of the Republic of Indonesia Number 45 of 2013 concerning the Coordination of the Repatriation of Indonesian Migrant Workers to overcome them, but in its implementation, there are still obstacles that occur, especially in the funding sector. Nevertheless, the Government must continue to ensure the presence of TKI starting from the pre-placement stage, during placement, and after placement. This conception of employment is used as a reference for reviewing the existing legal instruments, whether they already cover these fields or not.
Implications of Public Trust Due to Weak Law Enforcement Morality
Authors: Sakti Koeswanto Eka , Riswandi Riswandi , Redi Ahmad
Published: March 2023

Law enforcement has a strategic role in determining the quality of law enforcement in a country. In Indonesia, the performance of law enforcers is often considered unsatisfactory. This public dissatisfaction is a sign of weak law enforcement in Indonesia. The law which is considered a way to seek justice for society gives a sense of injustice. One of the causes of weak law enforcement in Indonesia is the quality of law enforcement. The low level of morality results in a lack of professionalism and unwillingness to enforce law enforcement. This morality is also related to corruption by law enforcement officers (judicial corruption). Law enforcers who are supposed to enforce the law are involved in corrupt practices. This low mortality causes law enforcement in Indonesia to be weak. Law enforcement will be strong and respected if law enforcers act professionally, and honestly and apply the principles of good governance. One example of weak law enforcement fines for drivers who violate traffic rules. Not a few motorists who do not want to be tried in court and choose the "peaceful place" route. This has been happening for years so it has become an open secret. As a result, there is public distrust of law enforcement. If not resolved immediately, this public distrust can lead to vigilante action. People who don't trust law enforcement may prefer to solve problems with violence or their way. A legal expert Leon Duguit said that the law is a rule of public behavior that must be obeyed as a guarantee of the common interest, which if violated will lead to criticism as a reaction. Meanwhile, law enforcement is a system in which there is a government or state institution that acts in an organized manner to ensure justice and order by using instruments or tools of power.
Analysis Of Land Disputes Arising From Land Procurement Activities In The Development Of Public Facilities And Infrastructure (Review of Law Number 2 of 2012 concerning Land Acquisition
Authors: Jasi Askolani , Isretno Israhadi Evita , Riswadi Riswadi
Published: March 2023

The phenomenon of the pros and cons of the Cipta Field or Omnibus Law regulations, for those who are pro, is the right solution to address the problem of overlapping laws and regulations in Indonesia. Whereas those who are against, think that the omnibus law plan is seen as an effort to delegitimize the rights of every sector of national life, especially regarding employment and other sectors that may be affected by its implementation. Thus, the implementation of the Omnibus Law must be seen from various aspects, including legal theory and more technical aspects of state administrative law in the Unitary State of the Republic of Indonesia
Analysis of Land Disputes Arising from Land Procurement Activities in the Development of Public Facilities And Infrastructure (Review of Law Number 2 of 2012 concerning Land Acquisition)
Authors: Rainhard Marchello Ryan , Isretno Israhadi Evita , Suparno Suparno
Published: March 2023

Land as a living space with all the people has a social function that must be able to maintain a balance between individual interests, social interests, and the interests of the state. Infrastructure development in the frame of public interest is closely related to land as the medium. So that land and development activities are a unit that cannot be separated from each other. The consequences of this have implications for the existence of land procurement for the public interest (land procurement for public interest) in realizing the welfare of the lives of its citizens who are just and prosperous equally as the goal of being an Indonesian state as stated in the fourth paragraph of the 1945 Constitution of the Republic of Indonesia. The study shows the implementation of land acquisition that is not by applicable legal procedures, the occurrence of maladministration and implementation errors such as lack of socialization, not involving all land rights holders, and there is no dialogue process between the parties before determining the location of the development, compensation that does not accommodate all non-physical needs of society. This error caused a dispute in the infrastructure development process because it was not by the mandate of Law Number 12 of 2012 concerning Land Procurement for Development in the Public Interest.
Juridical Overview of Misappropriation of Medical Devices Procurement Budget By Hospitals
Authors: Ratna Kusumawati Leti , Arief Fakrulloh Zudan , Isretno Israhadi Evita
Published: March 2023

The existence of corruption in Indonesia is alarming, the increase in corruption cases has brought misery to the community so its existence must be eradicated. The Corruption Eradication Commission as the institution for eradicating corruption in Indonesia must be responsive and participate in supervising every activity related to budgeting for state needs, to ensure the actual realization of budgeting. Based on the Decree of the Head of the Madiun District Health Office Number: 188.45/1464/KPTS/402.102/2011, the judge considered that the actions taken by the defendant fulfilled all the elements of Article 3 of Law Number 31 of 1999 concerning the Eradication of Corruption Crimes in conjunction with Article 55 paragraph ( 1) item 1 of the Criminal Code (KUHP). Even though the Public Prosecutor charged the defendant with Article 2 of Law Number 20 of 2001, the Judge considered that the Public Prosecutor could not prove the "unlawful" element of what the defendant did. Therefore, based on facts and analogies, the Judge judged that Article 3 was appropriate to be applied. The application of criminal sanctions against people as perpetrators of criminal acts of corruption is what has been regulated in Law Number 31 of 1999 in conjunction with Law Number 20 of 2001. However, the formulation of sanctions in several articles in Law Number 20 of 2001 contradicted the general provisions regarding sanctions regulated in the Criminal Code (KUHP).
Juridical Overview of Land Dispute Settlement
Authors: Munir Misbakhul , Budianto Azis , Sara Rineke
Published: March 2023

Along with the times, the way people view land slowly began to change. In the past, land was only considered a supporting factor for agricultural activities, but now it has been seen from a more strategic perspective, namely as an important asset in the world of industry and human life. Now a lot of lands has been used not only as a place for agricultural activities but also for industrial activities, including being used as an integrated residential complex such as housing which has recently mushroomed everywhere. Settlement of land dispute cases as regulated in Law Number 51 of 1960, in article 2 and article 6 paragraph (1) letter a, that the use of land without permission from those who are entitled or their legal proxies is a prohibited act and is threatened with criminal penalties. However, in responding to conflicts and land disputes that arise, one must look at it from several points of view while still prioritizing justice and not harming both parties, so it is not only seen from the side of the occupation, but also in terms of the utilization and use of the land by the community owner if in terms of utilization the land is not utilized optimally and even seems to have been neglected by the owner for approximately 15 years. Settlement of disputes through deliberation with mediation is taken as a path to resolving land problems, considering that the main purpose of mediation is to resolve problems, not just applying norms or creating order, but its implementation must also be based on general principles.
Analysis of Laws for the Protection of Indonesian Migrant Workers Abroad
Authors: Purnamasari Wita , Isretno Israhandi Evita , Barthos Megawati
Published: March 2023

The situation of TKI abroad during the last few years has been very concerning and has received little attention from the government, the problem of TKI is considered less important and the government has only been busy talking when cases surfaced in the community and received negative responses from the community. Quoted from Republika.co.id Domestic violence (KDRT) among Indonesian citizens living in Australia has increased recently. Legal protection for female workers abroad who are victims of exploitation-rape currently prioritizes the fulfillment of the rights of victims who work legally abroad. The rights of all migrant workers and their families, as well as ILO conventions beforehand, contain elements to protect workers from Indonesia when they encounter a legal challenge in the host country of migrant workers. In addition, guidance is carried out by the government through BNP2TKI and BP3TKI by Article 90 of Law No. 39 of 2004 concerning the Placement and Protection of Overseas Workers, such as providing guidance and advocacy for TKI starting from pre-placement, placement, and post-placement periods. TKI understand the legal system of the TKI receiving country so that if the TKI encounter legal problems, they will know what to do. And also the activeness of ambassadors, consular officers, and attaches in establishing cooperation related to the protection of Indonesian workers who are victims in countries receiving TKI in various forms of diplomatic relations and MoUs
Pre-Trial Legalefforts Due to the Establish Ment of the Suspective Criminalactions of the Corruption Eradiction Commission (KPK)
Authors: Rohman Syaepul , Budianto Aziz
Published: March 2023

Violating the provisions of Law Number 31 of 1999 concerning Eradication of Criminal Acts of Corruption as amended by Law Number 20 of 2001 concerning Amendments to Law Number 31 of 1999 concerning Eradication of Criminal Acts of Corruption, the alleged perpetrators must be carried out due process. law enforcement to prove that the party can be proven guilty or innocent, which is carried out based on formal legal provisions, namely Law Number 8 of 1981 concerning the Criminal Procedure Code or abbreviated as KUHAP. One of the legal efforts to ratify or not determine the suspect is through pretrial legal efforts.
The research problems are; 1. What is the legal action of the KPK investigators based on the Criminal Procedure Code in determining the suspect as the perpetrator of a corruption crime? The research method is carried out through the Approach Method, namely; normative juridical research.
The results of this study, that; The competence of the KPK's authority, according to Law Number 30 of 2002 concerning the Corruption Eradication Commission, is substantively responsible for operations in terms of carrying out legal actions for investigating and prosecuting perpetrators of criminal acts of corruption, based on Article 6 point c, Article 7 point a, Article 8 paragraph (2), Article 10, Article 11, Article 12 and Article 62 related to the provisions of the procedural law of actions and legal remedies.
Upon the determination of the suspect as the perpetrator of a criminal act of corruption, the person concerned shall carry out Pretrial Legal Efforts. The decision of the pre-trial lawsuit was granted and the determination of the suspect was declared legally flawed. For this reason, it is recommended that in order to avoid the possibility of arbitrariness in legal action by KPK investigators in conducting investigations that end in the determination of suspects, the KPK Supervisory Board should be active in conducting supervision and providing sanctions against investigators if the suspect is proven to be illegal and legally flawed.
Pelaksanaan Pembinaan Narapidana Residivis di Lembaga Pemasyarakatan Kelas IIB Pangkalan BUN
Authors: Mandala Sutra Bahtiyar
Published: March 2023

Suatu kejahatan yang dianggap belum diskriminasi tidak berarti perbuatan tersebut tidak dapat dikenakan sanksi. Apabila perilaku itu dinilai sebagai perilaku yang jahat dan atau merugikan masyarakat, maka pelakunya pasti memperoleh sanksi social. Tujuan yang hendak dicapai dari penulisan skripsi ini adalah memperoleh gambaran yang jelas tentang faktor-faktor yang menyebabkan narapidana menjadi residivis, mengetahui manfaat dalam penerapan yang dilakukan dan Lembaga Pemasyarakatan Kelas IIB Pangkalan Bun dalam upaya mendukung pembinaan narapidana residivisme,   dan   mengetahui   keberhasilan   pembinaan   narapidana ditinjau dari kondisi over kapasitas di Lembaga Pemasyarakatan Kelas I Cirebon. metode rekonstruksi mindset mereka dengan pelibatan berbagai pihak. Hasil dari penelitian ini adalah dalam pembinaan narapidana residivis dapat diterapkan pembinaan kepribadian yang dimaksudkan untuk memberi kesempatan kepada narapidana residivis mengutarakan segala keluh kesahnya agar ia dapat mengatasi masalah yang dialaminya dengan berkonsultasi kepada petugas jika dipandang perlu. Petugas pemasyarakatan sebagai pembina dan pembimbing berusaha untuk menjadikan mereka manusia yang mandiri, menyesali dan menyadari kesalahan yang mereka lakukan serta memberi motivasi untuk mengikuti program pembinaan yang diberikan dalam Lapas agar apa yang menjadi sasaran pembinaan tercapai
Urgensi Prinsip Kehati-Hatian dalam Penyaluran Kredit Produk Digital Lending Perbankan Nasional
Authors: Santoso Rahmat
Published: March 2023

Perkembangan teknologi informasi dan munculnya pesaing baru perbankan konvensional yang menjalankan fungsi penyalurkan kredit secara digital oleh perusahaan financial technology (fintech), menuntut perbankan konvensional melakukan terobosan dalam penyaluran kredit ke masyarakat berbasis aplikasi produk digital lending, sehingga masyarakat lebih mudah mengakses produk-produk keuangan, mempermudah transaksi dan juga meningkatkan literasi keuangan. Penting bagi perbankan nasional untuk tetap berpedoman kepada prinsip kehati-hatian dalam penyaluran kredit produk digital lending
Implementasi Metode Canny dalam Deteksi Tepi pada Aplikasi OMR (Optical Mark Recognition) Menggunakan Pengembangan Sistem Waterfall
Authors: Rizki Pratama Muhamad , Faqihuddin Hanif Isa
Published: March 2023

Pengolahan citra digital merupakan suatu teknologi input berupa gambar seperti foto atau video yang dapat dimanfaatkan dalam meningkatkan kualitas suatu citra, sedangkan output dari pengolahan citra visual dapat berupa gambar atau sejumlah karakteristik yang berkaitan dengan sebuah gambar. Serta proses dalam identifikasi citra tersebut dibantu dengan menggunakan beberapa metode dengan maksud mengembangkan sistem yang bersumber pada citra tersebut. Dalam hal ini, penerapan teknik pengolahan citra digital akan digunakan pada objek lembar jawaban untuk mempercepat dan mempermudah proses mengoreksi hasil ujian dengan konsep visi komputer (Computer Vision). Pengembangan teknologi dengan standar Computer Vision ini, sebagaimana diterapkan dalam proses mengoreksi hasil ujian layaknya Lembar Jawaban Komputer (LJK) yang menggunakan alat mesin pemindai OMR. Pada penelitian ini, sebelum melakukan implementasi terhadap citra lembar jawaban dan teknologi OMR maka dilakukan tahapan preprocessing, segmentasi threshold hingga tahapan melakukan deteksi jawaban pada lembar jawaban. Aplikasi ini diimplementasikan dengan memanfaatkan library opencv serta metode Canny dengan kombinasi alur pengembangan sistem Waterfall. Penelitian ini menggunakan 15 dataset citra lembar jawaban. Dimana masing masing komposisi citra yaitu 8 hasil foto lembar jawaban sebagai citra arsiran penuh, 5 hasil foto lembar jawaban sebagai citra arsiran separuh dan 2 hasil foto lembar jawaban sebagai citra arsiran salah. Adapun hasil akurasi yang diberikan pada uji coba semua citra yang dilakukan ialah 93%.
The Influence Of Accounting Information Systems, Internal Control Systems And The Implementation Of Good Corporate Governance In Efforts To Prevent FRAUD
Authors: Irfan Florid Muhammad , Feri Hendra Rudi , Purnamasari Pupung
Published: March 2023

Fraud, corruption, misuse of assets, and embezzlement of funds are still a scourge for most companies, especially companies engaged in financial services. This is because the processing of work that has been divided into tasks and authorities and the expansion of supervision of company elements makes the scope of supervision wider. The writing method used in this scientific article is a qualitative method and literature review (Library Research). In studying theories and relationships, ausality or influence between variables comes from books and journals that are accessed offline or online. from Google Scholar, Mendeley, or other online media. This scientific article is a qualitative descriptive type that emphasizes the actual problem and research that describes the Effects of Accounting Information Systems, Internal Control Systems, and the Implementation of Good Corporate Governance in Efforts to Prevent Fraud. This study aims to determine how accounting information systems, systems influence Internal Control and Implementation of Good Corporate Governance in Efforts to Prevent Fraud with the method used is to conduct a literature review of relevant previous research. These results indicate that the Accounting Information System,iInternaliControliSystemianditheiImplementation of Good Corporate Governance I have an affection Fraud Prevention. The conclusions from the results of the literature test in this study are as follows: The Accounting Information System has a positive effect on Fraud Prevention, and Internal Control has a positive effect on Fraud Prevention. The implementation of Good Corporate Governance has a positive effect on Fraud Prevention.
Socioeconomic Factors And Participation Of KB Suku Bajo Jaya Bakti Village, Pagimana Distritrict Banggai County Town, Central Sulawesi Province
Authors: HM Syamsuddin
Published: March 2023

This study aims to analyze the relationship of faktor sosial economy with the partition of the KB pasi of the Bajo Tribe community, what factors cause the Bajo Tribe to still survive together in several heads of families in one house in Jaya Bakti Village. The sample determination method uses purposive sampling. snowball sampling. The statistical analysis method used is descriptive analysis followed by cross-tabulation analysis and Chi-Square. The results showed that the average education of this study sample was mostly (67,3,1%) educated in elementary school. From the income aspect of 74 respondents, 35 respondents or 47.4% belonged to the poor group. Most of the research samples worked as fishermen.There was a relationship between income and the use of contraceptives for married couples in research in the Bajo Tribe.
Combined Training Reduces Redox and Inflammatory Biomarkers and Improves General-Social Health in Elderly Men
Authors: Cheragh Birjandi Kazem , Ghasemi Elham , Karimi Ehsan , Ghoncheh Sajjad
Published: March 2023

Background: Increased inflammation and oxidative stress are the main causes of many common diseases of old age. Objectives: The aim of the present study was to evaluate the effects of combined training on inflammatory and oxidative markers and the general-social health of overweight older male adults. Methods: In this quasi-experimental study, 40 overweight older male adults with an age range of 60 - 75 years were purposefully selected and randomly divided into two training and control groups. The training program included aerobic, resistance, and balance training for eight weeks and three days a week. Study variables were measured 48 hours before and after the intervention. The statistical analysis of the data was done by two-way repeated measure analysis of variance and Tukey's post hoc tests at a significance level of P ≤ 0.05. Results: After eight weeks of combined training, levels of TNF-α (P ≤ 0.01), hs-CRP (P ≤ 0.03), and MDA (P ≤ 0.01), the mass of fat (P ≤ 0.04) decreased, while the level of superoxide dismutase (P ≤ 0.01) and the score of social health (P ≤ 0.01) increased significantly. Conclusions: It seems that combined training in the elderly is a suitable option for modulating and regulating inflammatory and oxidative biomarkers and improving general social health.
Targeting Caspase-3 Gene in rCHO Cell Line by CRISPR/Cas9 Editing Tool and Its Effect on Protein Production in Manipulated Cell Line
Authors: Rahimi Amirabbas , Karimipoor Morteza , Mahdian Reza , Alipour Atefeh , Hosseini Sadi , Kaghazian Hooman , Abbasi Abdolrahim , Shahsavarani Hosein , Shokrgozar Mohammad Ali
Published: March 2023

Background: Chinese hamster ovary (CHO) cells are the widely used mammalian cell host for biopharmaceutical manufacturing. During cell cultures, CHO cells lose viability mainly from apoptosis. Inhibiting cell death is useful because prolonging cell lifespans can direct to more productive cell culture systems for biotechnology requests. Objectives: This study exploited a CRISPR/Cas9 technology to generate site-specific gene disruptions in the caspase-3 gene in the apoptosis pathway, which acts as an apoptotic regulator to extend cell viability in the CHO cell line. Methods: The STRING database was used to identify the key pro-apoptotic genes to be modified by CRISPR/Cas9 system. The guide RNAs targeting the caspase-3 gene were designed, and vectors containing sgRNA and Cas9 were transfected into CHO cells that expressed erythropoietin as a heterologous protein. Indel formation was investigated by DNA sequencing. Caspase-3 expression was quantified by real-time PCR and western blot. The effect of editing the caspase-3 gene on the inhibition of apoptosis was also investigated by induction of apoptosis in manipulated cell lines by oleuropein. Finally, the erythropoietin production in the edited cells was compared to the control cells. Results: The caspase-3 manipulation significantly prolongation of the cell viability and decreased the caspase-3 expression level of protein in manipulated CHO cells (more than 6-fold, P-value < 0.0001). Manipulated cells displayed higher threshold tolerance to apoptosis compared to the control cells when they were induced by oleuropein. They show a higher IC50 than the control ones (7271 µM/mL Vs. 5741 µM/mL). They also show a higher proliferation rate than the control cells in the presence of an apoptosis inducer (P-value < 0.0001). Furthermore, manipulated cell lines significantly produce more recombinant protein in the presence of 2,000 µM oleuropein compared to the control ones (P-value = 0.0021). Conclusions: We understood that CRISPR/Cas9 could be effectively applied to suppress the expression of the caspase-3 gene and rescue CHO cells from apoptosis induced by cell stress and metabolites. The CRISPR/Cas9 system-assisted caspase-3 gene ablation can potentially increase erythropoietin yield in CHO cells.
Tumor Suppression by PD-1/PD-L1 Interaction Blockage in Mice Model
Authors: Salehi Shima , Ghaderi Hajarossadat , Habibi-Anbouhi Mahdi , Shoari Alireza , Hassanzadeh Eskafi Ayda , Sabouri Alireza , Hosseininejad-Chafi Mohammad , Ashja Ardalan Arghavan , Ramezani Behzad , Kazemi-Lomedasht Fatemeh , Behdani Mahdi
Published: March 2023

Background: Overexpression of programmed cell death ligand 1 (PD-L1) in tumor cells and subsequent interaction with the programmed cell death protein 1 (PD-1) in tumor-infiltrating T cells cause an immune evasion of the tumor from cytotoxic T-cells. Therefore, inhibiting such interaction by a recombinant PD-1 can hinder tumor growth and extend the survival rate. Methods: The mouse extracellular domain of PD-1 (mPD-1) was expressed in E. coli BL21 (DE3) strain and purified using nickel affinity chromatography. The binding ability of the purified protein to human PD-L1 was studied using ELISA. Finally, the tumor-bearing mice were used to evaluate the potential antitumor effect. Results: The recombinant mPD-1 showed a significant binding capacity to human PD-L1 at the molecular level. The tumor size significantly decreased in the tumor-bearing mice after the intra-tumoral injections of mPD-1. Moreover, the survival rate increased significantly after eight weeks of monitoring. The histopathology revealed the necrosis in the tumor tissue of the control group compared to the mPD-1 received mice. Conclusions: Our outcomes propose that interaction blockade between PD-1 and PD-L1 is a promising approach for targeted tumor therapy.
Comparing Effects of Massage Therapy and Music on Chemotherapy-Induced Nausea and Vomiting in Cancer Children: A Randomized Control Trial
Authors: Akbari Sakineh , Nematollahi Moniralsadat , Dehghan Mahlegh , Sabzevari Sakineh
Published: March 2023

Background: Nausea and vomiting are common complications of chemotherapy. Objectives: The present study aimed to evaluate the efficacy of massage and music on chemotherapy-induced nausea and vomiting (CINV) in the pediatric oncology ward in 2017. Methods: The present randomized controlled trial used the convenience sampling method, and all samples were randomly assigned to two massage or music therapy groups. Accordingly, all subjects received one massage session and one music session, with one washout session between the two interventions. The severity of nausea and vomiting before, immediately after, and one hour after chemotherapy was assessed using the Visual Analogue Scale (VAS) and after 12 hours using the adapted Rhodes index of nausea and vomiting for pediatrics by child (ARINVC). The collected was analyzed with SPSS software version 18 using the repeated measures analysis of variance, Friedman test, chi-square, Fisher's exact, and independent t-test. Results: The results showed that nausea and vomiting scores were not significantly different between the two groups (P > 0.05). However, the scores significantly increased in both methods immediately after the intervention, simultaneous with chemotherapy (P < 0.05), and decreased below the baseline; however, they were not significantly different from the pre-intervention scores (P > 0.05). In the second phase, one hour after the intervention, the scores of nausea and vomiting decreased below the baseline, which was significantly different from the pre-intervention scores (P < 0.05). Conclusions: The massage or music therapy methods revealed no difference in reducing the severity of chemotherapy-induced nausea and vomiting in children. Nurses can use non-medicinal methods such as massage and music to reduce the complications of chemotherapy, especially nausea, and vomiting.
Physical Activity During the Corona Period and Its Relationship with the Physical and Mental Health of Children and Adolescents
Authors: Mehrabani Javad , Fayaz Elham
Published: March 2023

Context: This review article aims to discuss physical activity during the corona period and its relationship with the physical and mental health of children and adolescents. Methods: A literature search was conducted on the Pub-Med, Wiley, ScienceDirect, and Springer databases from 2020 to 2022 to find related articles scientiﬁc. Search engines were searched on September 7, 2022, using the following keywords: Exercise and children and adolescents and COVID-19, physical activity and children and adolescents and COVID-19, sport and children and adolescents and COVID-19, physical activity and children and adolescents and COVID-19 and physical and mental health. Results: The present ﬁndings revealed a decline in physical activity levels in children and adolescents during the COVID-19 pandemic. These reductions were associated with various physical and mental health problems. It seems there is a difference in the prevalence of insufficient physical activity across genders, regions, and countries. Conclusions: Restrictions on mobility, social distancing, or closure of schools, clubs, and recreational centers, although an effective measure against the spread of COVID-19, have caused an increase in sedentary behavior, and so the incidence of numerous mental and physical health problems. Therefore, these limitation periods should be shortened as much as possible.
Comparison of Combined Aerobic-Resistance and Aerobic Training on Heart Systolic Function in Heart Failure Patients After Coronary Artery Bypass Graft Surgery (CABG)
Authors: Amiripour Mohammad Sobhan , Amiripour Asadollah , Nasiri Siroos , Omidi Sepideh , Raisi Farshid
Published: March 2023

Background: Heart disease is the most common cause of mortality worldwide, and heart surgery frequently occurs. The results are strongly dependent on lifestyle modification and especially sports exercises. Objectives: In this study, aimed to compare the effect of eight weeks of aerobic and combined training on systolic cardiac function in heart failure patients after coronary artery bypass surgery. Methods: In this randomized clinical trial, 30 cardiac patients under CABG surgery at Kermanshah Heart Center were randomly divided into three groups, control, combined, and aerobic training. The protocols of the combined group included two movements of the upper limbs (pectoralis major and deltoid muscles) and two movements of the lower limbs (quadriceps and hamstring muscles) by three sets/10Rep and aerobic group with 60 - 85-minute exercises at 70 - 85% peak HR in three sessions per week for eight weeks. The collected data were analyzed using the SPSS software version 22, One-way ANOVA, and Tukey tests; P < 0.05 was considered significant. Results: After eight weeks, Systolic heart function wasn’t increased in the control group (P > 0.05) but was raised in the aerobic and combined training groups (P = 0.0001). There was no significant difference between in two intervention groups (P > 0.05). Conclusions: Aerobic and combined exercises positively affect systolic cardiac function after coronary artery bypass surgery. Therefore, doing both exercises in these patients is recommended.
Efficacy and Safety of Modified Polyethersulfone Hemodialysis Filters in Comparison to Conventional Filters: A Non-inferiority Clinical Trial
Authors: Taheri Shahram , Mortazavi Mojgan , Shahidi Shahrzad , Atapour Abdolamir , Kazemi Naeini Maryam , Zamani Zahra , Ghasemi Golsa
Published: March 2023

Background: The efficacy and quality of hemodialysis (HD) are closely related to the dialyzer characteristics. Objectives: This study aimed to determine the efficacy and complications of modified polyethersulfone (m-PES) -1.5 hollow fiber filters in comparison to conventional filters during HD. Methods: This non-inferiority crossover randomized clinical trial was performed in adult dialysis units at three HD centers within May 2019 to March 2020. The patients were randomly enrolled in two groups. Group A was first put on HD for six sessions with a low or high flux smart flux filter (m-PES-1.5 hollow fiber), which was made in Italy by Medica S.P.A. Group. Group B was hemodialyzed with a corresponding low or high flux filter made in Iran by Meditechsys Company. After a two-week clearance phase, the patients were dialyzed for six sessions with the opposite filter of the first six sessions. Laboratory variables, such as blood urea nitrogen and creatinine, were measured. Kt/V (i.e., a measurement of HD efficacy) and urea reduction ratio (URR) were calculated. Additionally, blood pressure was monitored. Results: A total of 40 patients were entered into the final analysis. No matter which filter was used, no statistically significant differences were observed in URR, creatinine, Kt/V, and blood pressure at different times during dialysis between the two types of filters. Packaging problems (P < 0.001) and blood clotting (P = 0.009) were two more frequent complications in the m-PES group. Conclusions: This study showed that smart flux m-PES-1.5 hollow fiber filters are similar to Meditechsys Company filters.
Transformation of a traditional face-to-face engineering study program into a digital online program - A case study of global production engineering
Authors: Eingartner Valentin , Severengiz Mustafa , Muschard Bernd , Kohl Holger
Published: March 2023

The need for Digital Education (DE) in higher education has been growing for the past years, as the landscape of education became more diverse and global. It has become apparent with the COVID-19 pandemic that, in terms of width, DE had been mostly neglected so far. In the past year, the master program Global Production Engineering (GPE) at Technische Universität Berlin has been enhanced by a complete digital track, called GPE-Digital. In order to design this online study program a student survey was conducted and lecturers have been interviewed. The results were analysed and requirements for both lecturers and students were identified. Chances and challenges have been identified and a “tool box” for teaching and learning was developed. It contains a multimedia studio, a learning platform, a cloud platform et cetera. Lecturers are supported to develop and adapt their lecture-concepts and to choose the tools needed, which led to a variance of teaching-concepts. In this paper, after presenting the findings of both the interviews and the survey, the “tool box” is presented and its various possibilities for implementation are shown by the example of four different courses offered at GPE-Digital. These examples contain both synchronous and asynchronous teaching and different approaches of preparing joint sessions and lectures. Finally, based on the courses the benefits and challenges are discussed and rough approaches for exploiting the benefits and tackling the challenges are given.
A practical approach to statistics through SRP
Authors: Freixanet de la Iglesia Maria Josep , Alsina Aubach Montserrat , Bosch Casabò Marianna
Published: March 2023

The paper explains the design and the first part of the implementation of a project within the subject of Statistics with first year students in a Bachelor’s degree in ICT Systems Engineering in Manresa School of Engineering, part of the Universitat Politècnica de Catalunya. We use the methodology of study and research paths within the Anthropological Theory of the Didactic and under the paradigm of “Questioning the world”. The project topic is the “water”. The experience is linked to a broader UPC-driven project, called AquaeSTEAM, based on questions to spark new ideas and science and technology solutions to solve water-related problems. After narrowing down the issue to concrete problematic questions, the students analyse data published in IDESCAT, the Statistical Institute of Catalonia, related to water consumption, both domestic and industrial, factors related to climate change, such as temperature and pluviometry, among others, and will also carry out a survey to link all these studies with the water footprint. The implementation sheds light on the conditions needed to integrate project-based proposals in the traditional organisation of the subject. It also provides information about the changes that may take place to facilitate the integration, in both the subject’s content and instructional structure (lectures and tutorials). The conditions required are then compared with other experiences of study and research paths in engineering education carried out these past years in the Anthropological Theory of the Didactic.