bluuebunny/crossref_metadata_2025 huggingface dataset:
Elevated level of ambient glucose stimulates the synthesis of high-molecular-weight hyaluronic acid by human mesangial cells. The involvement of transforming growth factor beta1 and its activation by thrombospondin-1.
Authors: Yevdokimova Natalia Yu
Published: November 2019

The dysregulation of the metabolism of glycosaminoglycan and protein components of extracellular matrix (ECM) is a typical feature of diabetic complications. High glucose-induced enrichment of ECM with hyaluronan (HA) not only affects tissue structural integrity, but influences cell metabolic response due to the variety of effects depending on the HA polymer molecular weight. TSP-1-dependent activation of TGFbeta1 axis is known to mediate numerous matrix disorders in diabetes, but its role concerning HA has not been studied so far. In this work we demonstrated that 30 mM D-glucose increased the incorporation of [(3)H]glucosamine in high-molecular-weight (> 2000 kDa) HA of medium and matrix compartments of human mesangial cultures. Simultaneously, the synthesis of HA with lower molecular weight and HA degradation were not altered. The cause of the increased high-molecular-weight HA synthesis consisted in the up-regulation of hyaluronan synthase (HAS) 2 mRNA without alterations of the expression of HAS3, which generates HA of lower molecular weight. D-Glucose at 30 mM also stimulated the production of transforming growth factor beta1 (TGFbeta1), the excessive activation of which was determined by the up-regulation of thrombospondin-1 (TSP-1). The blockage of TGFbeta1 action either by neutralizing anti-TGFbeta1 antibodies or by quenching the TGFbeta1 activation (with TSP-1-derived synthetic GGWSHW peptide) abolished the effect of high glucose on HAS2 mRNA expression and normalized the synthesis of HA. Exogenous human TGFbeta1 had the same effect on HAS2 expression and HA synthesis as high glucose treatment. Therefore, we supposed that TSP-1-dependent TGFbeta1 activation is involved in the observed high glucose effect on HA metabolism. Since high-molecular-weight HA polymers, unlike middle- and low-molecular weight HA oligosaccharides, are known to possess anti-inflammatory and anti-fibrotic functions, we suppose that the enrichment of mesangial matrix with high-molecular-weight HA may represent an endogenous mechanism to limit renal injury in diabetes.
A novel polypeptide from Cervus nippon Temminck proliferation of epidermal cells and NIH3T3 cell line.
Authors: Guan Shu-Wen , Duan Leng-Xin , Li Yuan-Yuan , Wang Ben-Xiang , Zhou Qiu-Li
Published: November 2019

A novel polypeptide, velvet antler polypeptide (VAPPs), having a stimulary effect on proliferation of some cell was isolated from the velvet antler of sika deer (Cervus nippon Temminck). This polypeptide consists of a single chain of 32 amino-acid residues VLSAT DKTNV LAAWG KVGGN APAFG AEALE RM. VAPPs showed marked stimulary effect on rat epidermal cells and NIH3T3 cell line (dose range from 10-40 mg x L(-1) and 5-80 mg x L(-1), respectively).
DETERMINANT OF PERSONAL TAX COMPLIANCE IN INDONESIA
Authors: Yulianto Yulianto , Rosalia Feni , Brima Atika Dewi , Alamsyah Alamsyah
Published: November 2019

Purpose of the study: This article aims to analyze the effect of eight independent variables (happiness, level of welfare, electoral participation, sex, age, marital status, type of residence, and level education) on tax compliance in Indonesia. Methodology: The cross-sectional study data came from the 5th wave of the Indonesian Family Life Survey (IFLS 5) produced by Rand Corporation, Ltd, United States, in 2014-2015. The total sample of IFLS 5 reached 16,204 households and 50,418 individuals as household members. IFLS 5 respondents are household heads, spouses of heads household, and household members aged 15 years old or older who can provide information about the characteristics of household members. This article applies logistic regression using STATA 15 to analyze the IFLS 5. Main Findings: The result of logistic regression shows that of the eight independent variables identified as predictors of tax compliance (Y), only five independent variables (p<0.01) significant affect tax compliance (Y) with a contribution as much as 128.1% (electoral participation/X8), 61.1% (welfare/X2), 54% (happiness/X1), -37% (age/X3), 17.9% (education level/X7). Among these five independent variables, only the age (X3) has a negative relationship with tax compliance (Y), while the other independent variables have a positive relationship. This final model can explain tax compliance (Y) of 0.0275 or 3% significantly, X2 (5) = 459.46, p<0.01. Applications of this study: This article recommends that the government intervene in various sectors of social development, increase tax literacy, expand access to higher education, and improve the quality of the democratization process to increase tax compliance in Indonesia. Novelty/originality of this study: This article brings new evidence on the relationship between happiness, welfare, electoral participation, age, and education level on personal tax compliance.
Entre razón y derecho: el papel de la lógica en la ciencia jurídica. De la glosa al computador
Authors: Errera Andrea
Published: November 2019

El presente ensayo se propone subrayar que la historia del derecho no es solo útil para comprender el derecho actual, sino que es incluso indispensable para guiar y valorar los desarrollos futuros de la vida del derecho: en efecto, algunas novedades de los últimos años pronto se harán evidentes a todos los juristas y traerán, inevitablemente, un cambio radical de la ya consolidada tradición doctrinal y jurisprudencial. Se trata de un cambio ligado a la inteligencia artificial (IA) jurídica, cuya aplicación gradual constituirá una transformación profunda, que podrá ser incluso dramática si se enfrenta sin la necesaria consciencia histórica.
Reparación del daño ambiental causado a las aguas subterráneas en los tribunales de Chile
Authors: Delgado Schneider Verónica
Published: November 2019

Este trabajo revisa casos de daños ambientales en aguas subterráneas en Chile, conocidos por los tribunales ordinarios y ambientales. Analiza las normas que determinan cuándo existe daño, cuándo es “significativo”, en qué consiste la “reparación” material, cuándo el daño es irreparable, etc., y cómo han interpretado estas normas los tribunales. Para concluir que la jurisprudencia ha evolucionado en relación con las medidas de reparación material ordenadas, centrándose preferentemente en los aspectos preventivos. La labor científica resulta primordial para identificar medidas concretas y efectivas de reparación, y para determinar cuándo un daño es irreparable.
Sentencia de unificación de la Sección Tercera del Consejo de Estado del 18 de julio de 2019 (exp. 44.572): ¿renacer de la tarifa legal de prueba?
Authors: Gaviria Cardona Alejandro
Published: November 2019

El Consejo de Estado precisó los criterios para el reconocimiento del lucro cesante y del daño emergente por privación injusta de la libertad. El primero exige prueba de que al momento de la retención se ejercía una actividad lucrativa y de que no se pudo continuar desempeñándola. De probarse esta, pero no los ingresos, se presumirá que devenga el salario mínimo legal mensual vigente (SMLMV). Ahora, las prestaciones sociales solo se incrementarán en caso de que exista una relación laboral. Con relación al segundo, fijó la prueba idónea para su reconocimiento: factura o documento equivalente y certificación del pago, lo cual nos ubica en el sistema de tarifa legal de prueba.
Klinik biyokimyada biyolojik varyasyon: Referansdeğişim değeri ve bireysellik indeksi
Authors: ÇOKLUK Erdem
Published: November 2019

Değişiklik (varyasyon), yaşam süresinin
ve ritmik biyolojik döngülerin bir sonucu olabilmesine rağmen, birçok analitin
biyolojik çeşitliliği, en basit modelde, homeostatik bir ayar noktasının
etrafındaki rastgele dalgalanma olarak tanımlanabilir. Biyolojik varyasyon
birey içi ve bireyler arası bileşenlerinin büyüklüğünü tanımlamak için çok
sayıda koşulu basit deneysel yöntem ile açıklamaktadır. Bu deneysel teknik
kullanılarak üretilen ortalama birey içi ve bireyler arası biyolojik değerler
ile ilişkili olarak RCV(referans değişim değer) ve II(bireysellik indeksi)
hakkında bilgi ve yorum yapılabilmektedir. Ayrıca, geleneksel popülasyona
dayalı referans değerlerin kullanımı ve uygunluğu, test sonuçlarını bildirmenin
en iyi yolunu, numune toplamanın en uygun şeklini ve en büyük potansiyel
kullanımı olan test prosedürünü belirlemeyi, epidemiyolojide kullanılan
güvenilirlik katsayısının hesaplanmasını, herhangi bir yeni test prosedürünün
geliştirilmesini, belirtilen bir olasılık ile belirli bir yüzde içindeki
homeostatik ayar noktasını tahmin etmek için gereken örnek sayısının
belirlenmesi için kullanılabilmektedir. Bu ve buna benzer kullanım
kolaylıklarının sağlanmasında yer almasından dolayı, bu derlemede biyolojik
varyasyon, referans değişim değeri ve
bireysellik indeksi hakkında bilgi sunmayı amaçladık.
Protective effects of hesperidin on ionizing radiation-induced liver damage
Authors: AYDIN Bengü Gülhan , PİŞKİN Özcan , BAŞ Yılmaz , KARAKAYA Kemal , ELMAS Özlem , CAN Murat , BÜYÜKUYSAL Çağatay
Published: November 2019

Aim: Liver
is mostly exposed to radiation during radiotherapy to the upper abdomen, the
right lobe of the lung, distal esophagus tumors or total body irradiation.
Radiation may lead to cellular damage, and clinical and laboratory findings of
liver dysfunction. This study aimed to
investigate the protective effect of peroral hesperidin on reducing oxidative
stress in liver tissue  caused by
ionızing radiation Material and Methods: 24
adult male rats were randomly divide into four groups. Group control
was given only physiological saline, Group HES was given hesperidin at 50 mg/kg
body weight (BW) for 15 days, Group RAD was given only irradiation, and Group
HES+RAD was given hesperidin at 50 mg/kg BW daily and then irradiated. At the
end of 15 hesperidinin days,
the animals in Groups RAD and HES+RAD were exposed to a dose of 10 Gy to the
abdominopelvic region. Liver and blood samples were used for determination of total
antioxidant status (TAS) and malondialdehyde (MDA) and also histopathological
examination was performed.Results: Compared
with the Group RAD, the plasma and tissue MAD level was significantly decreased
in Group HES+RAD (p=0.002). Both plasma and tissue levels of TAS was found
significantly higher in HES+RAD group (respectively, p=0.002,p=0.004). Histological
examination of Group RAD, portal edema, significant intra-cytoplasmic
vacuolization, swelling in the hepatocytes, necrosis, significant sinusoidal and
 central vein dilation and congestion
were observed . In group HES+RAD periportal edema, central vein dilation and
congestion were not histologically evident when compared with Group RAD.

Conclusion: Radiotherapy was found to lead to an increase in lipid
peroxidation and a reduction in anti-oxidant capacity; 50 mg/kg/day hesperidin
administration for 15 consecutive days was seen to reduce the histological
changes of liver damage and oxidative stress in rats
Comparación de la implementación en plataformas tradicionales y en nube: sistema de reportes meteorológicos
Authors: Flórez Zuluaga Jimmy Anderson , Orozco Montero Samuel Guillermo , Daza Hernández Wilmer Arley , Cardenal Moreno Edinson Rolando , Amariles Saldarriaga Luisa María
Published: November 2019

La infraestructura crítica, aporta costos importantes en el desarrollo de un proyecto de Tecnologías de la Información y las Comunicaciones (TIC); además de problemas como la latencia en la intercomunicación, la escalabilidad y la estabilidad de procesos en tiempo real, los cuales pueden generar dudas en los investigadores a la hora de determinar el uso de arquitecturas en la nube o tradicionales en un proyecto, criterio que afecta el presupuesto y la viabilidad del proceso. Con el fin de apoyar este tipo de análisis y facilitar la escogencia de la estructura a implementar, en este trabajo se propone un caso de estudio en el que se utilizó un proyecto sobre análisis meteorológico en tiempo real, en ambas plataformas de manera paralela y se evaluó el desempeño de las tecnologías en la nube versus las físicas. En el trabajo se describen los sistemas operativos, facilidades y características de ambas aproximaciones, para que sirvan de base en la elección de una u otra alternativa de acuerdo con las necesidades del proyecto. Para la evaluación, el proyecto fue implementado en plataformas en sitio y en plataformas de cloud computing, lo que permitió realizar una comparación entre ambas tecnologías, determinando diferencias en su infraestructura, seguridad, rendimiento y fiabilidad. Para la implementación se utilizó modelo de virtualización tradicional, usando el Hipervisor Esxi 6.0 de la empresa VMware, y para la infraestructura Cloud, se utilizó Microsoft Azure para la virtualización.
Implementación de un sistema remoto centralizado como una mejora para el mantenimiento aeronáutico
Authors: Gómez Gil José David , Gómez Gómez Edgar Leonardo
Published: November 2019

Este artículo describe el proceso de implementación de un sistema remoto de acceso de datos de navegación, desde el Aeropuerto central de la Regional Antioquia de la Aerocivil. El sistema opera en la terminal de trabajo del personal ATSEP (Personal electrónico para la seguridad del tráfico aéreo) y permite la obtención eficiente de datos de navegación desde las radioayudas a la navegación aérea localizadas en la Regional Antioquia. Mantenerlas operativas es prioritario para el cumplimiento misional de la Entidad y para la seguridad de los usuarios del espacio aéreo.

El problema presentado, era la dificultad para el acceso y la gestión de las radioayudas, dado que no se tenía un canal de conexión en tiempo real con las estaciones de la región. Para mitigar este problema, se diseñó un sistema de acceso remoto para interconectarlas con una estación central. Esto permitió suprimir costos innecesarios, por no trasladar personal técnico hasta el lugar de la radioayuda cuando hay una falla o alarma; además permitió monitorear y acceder a los sistemas de navegación de manera constante para su mantenimiento y operación y así, prestar un servicio 24/7 que garantice una seguridad aérea efectiva y confiable.

Para llevar a cabo este desarrollo, se instalaron diferentes radioenlaces que transportan los datos hasta la torre principal de cada aeropuerto dentro de la Regional y luego se integró la información a la red de la Aerocivil por medio de dispositivos de red (Port Server y Switch) que hacen parte del sistema implementado.

Los elementos que se usaron son reutilizados de sistemas desmontados con anterioridad por parte de la Aerocivil; con la utilización de estos elementos se logró implementar el sistema de manera eficiente, optimizando costos y aprovechando los materiales con los que cuenta la Entidad.
La interceptación de los Tupolev: enseñanzas desde la doctrina y la estrategia
Authors: Mezú Mina Rodrigo
Published: November 2019

El 1 de noviembre de 2013 dos aviones rusos tipo Tupolev, entre ellos el bombardero nuclear más rápido del mundo, ingresaron sin previa autorización sobre espacio aéreo nacional de Colombia. El proceso de interceptación y la toma de decisiones a nivel estratégico dejaron, desde la teoría de Colin S. Gray, reflexiones y enseñanzas necesarias para seguir evolucionando el proceso de toma de decisiones al interior del país y mantener la importancia de la estrategia en el uso del poder aéreo.  Las enseñanzas derivadas de dicha experiencia, en particular, le permite a Colombia reflexionar sobre cómo administrar una desventaja asimétrica frente a sus adversarios. También reconocer que las decisiones militares no son las únicas determinantes de la estrategia, sino también, la voluntad política, el compromiso de una nación y la conciencia por la defensa del país.
A Wild Roguery: Bruce Chatwin’s The Songlines Reconsidered
Authors: Nicholls Christine
Published: November 2019

This article revisits, analyzes and critiques Bruce Chatwin’s 1987 bestseller, The Songlines, more than three decades after its publication. In Songlines, the book primarily responsible for his posthumous celebrity, Chatwin set out to explore the essence of Central and Western Desert Aboriginal Australians’ philosophical beliefs. For many readers globally, Songlines is regarded as a—if not the—definitive entry into the epistemological basis, religion, cosmology and lifeways of classical Western and Central Desert Aboriginal people. It is argued that Chatwin’s fuzzy, ill-defined use of the word-concept “songlines” has had the effect of generating more heat than light. Chatwin’s failure to recognize the economic imperative underpinning Australian desert people’s walking praxis is problematic: his own treks through foreign lands were underpropped by socioeconomic privilege. Chatwin’s ethnocentric idée fixe regarding the primacy of “walking” and “nomadism,” central to his Songlines thématique, well and truly preceded his visits to Central Australia. Walking, proclaimed Chatwin, is an elemental part of “Man’s” innate nature. It is argued that this unwavering, preconceived, essentialist belief was a self-serving construal justifying Chatwin’s own “nomadic” adventures of identity. Is it thus reasonable to regard Chatwin as a “rogue author,” an unreliable narrator? And if so, does this matter? Of greatest concern is the book’s continuing majority acceptance as a measured, accurate account of Aboriginal belief systems. With respect to Aboriginal desert people and the barely disguised individuals depicted in Songlines, is Chatwin’s book a “rogue text,” constituting an act of epistemic violence, consistent with Spivak’s usage of that term?
Three Layers of Metaphors in Ross Macdonald’s Black Money
Authors: Zdunkiewicz Lech
Published: November 2019

In his early career, Kenneth Millar, better known as Ross Macdonald, emulated the style of Dashiell Hammett and Raymond Chandler. By the 1960s he had established himself as a distinct voice in the hardboiled genre. In his Lew Archer series, he conveys the complexity of his characters and settings primarily by the use of metaphors. In his 1966 novel Black Money the device performs three functions. In the case of minor characters, the author uses metaphors to comment on Californian society. Concurrently, metaphors describing major characters allow him to develop their dramatic arcs, whereas the recurring elements of the leitmotif serve to demonstrate the narrating detective’s growing concerns with the ongoing investigation. Arguably, it was Macdonald’s use of metaphors that helped define his unique voice.
POLA HUBUNGAN PEMBIAYAAN BANK SYARIAH TERHADAP PENINGKATAN JUMLAH WISATAWAN RELIGI/HALAL DAN PERTUMBUHAN PAD
Authors: Muhammad Iqbal Fadli
Published: November 2019

Penelitian ini bertujuan untuk menganalisa hubungan pembiayaan bank syariah terhadap peningkatan jumlah wisatawan religi/halal dan pertumbuhan pendapatan asli daerah (PAD) untuk periode 2015-2016 pada 33 provinsi, Indonesia. Menggunakan metode penelitian yaitu granger kausalitas dan regresi berganda data panel dengan alat analisis yang digunakan adalah minitab. Model ini menganalisa pengaruh kontribusi pembiayaan bank syariah terhadap jumlah wisata religi/halal dan peningkatan pendapatan asli daerah. Jumlah pembiayaan bank syariah pada sektor wisata seperti usaha rumah makan dan penginapan mempunyai kontribusi pengaruh  terhadap peningkatan jumlah wisatawan religi/halal dan pertumbuhan pendapatan asli daerah (PAD).  Hasil penelitian ini dapat digunakan bagi industri perbankan syariah untuk mendukung pembiayaan modal bagi industri halal. Pada penelitian terdahulu hanya hanya menganalisa potensi wisata religi/halal, serta potensi industri wisata secara umum bagi Pendapatan Asli Daerah (PAD). Namun pada penelitian ini membahas mengenai kontribusi pembiayaan bank syariah terhadap jumlah wisata religi/halal dan peningkatan pendapatan asli daerah (PAD).
VISIT THE TOMB OF KI MAROGAN: PRESERVATION OF RELIGIOUS TRADITION IN MUSLIM MALAY COMMUNITY
Authors: Trisiah Anita , Puspita Weni , Septiyanti Reni
Published: November 2019

The custom of some Palembang Malay Muslim communities to visit the tomb of Ki Marogan is a religious tradition that has lasted for years. This study wants to see what are the motives behind the Palembang Muslim community to maintain this tradition and how their perceptions of these pilgrimage habits. By using the method of observation and in-depth interviews found the fact that there are various motives behind the pilgrimage tradition to the Ki Merogan tomb, ranging from forms of respect for the figure of Ki Merogan Ulama, known as a charismatic figure of Ulama and its important role in the development of Islam in the city of Palembang, to with the motive of smelling khurafat in the form of a desire to pay a vow because their request was granted after praying at the grave of Ki Marogan. Meanwhile pilgrims consider that the tradition of pilgrimage to the grave of Ki Merogan is a good habit and does not violate Islamic teachings. Some even believe that the pilgrimage to the tomb of Ki Merogan is a must because it is a form of respect for the great ulemas of Palembang who have high karomah.
Peralihan Hak Milik Sukuk Tabungan Melalui Pewarisan
Authors: Setiawan Adam , Towidjojo Riansyah , Faisal Yazid Shidqi
Published: November 2019

AbstractOne of the instrument in the shariah capital market is sukuk (sharia bond). Sukuk can be issued by companies or countries. At present there are 7 state sukuk instruments that have been issued by the giverment, two of which are intended for individual investors Indonesian citizens. State sukuk for individual investors are retail sukuk and sukuk savings. Both retail sukuk and sukuk savings are the same as state sharia securities issued to encourage the Indonesian people to invest and assist the country development because the procceds from the sale of these two sukuk will be used state insfrastructure development. However  one of dissent is striking which this two sukuk is retail sukuk is tradable (transferable / traded) while the savings sukuk is non tredeble  (non- tradable / non-transferable). So, how if  thesukuk ownership pass away, is the sukuk ownership can change by legacy?. The nethode used in this is the statute approach and this research in the kegal context used a doctrinal legal research approach,  but it dosen not rule out the possibility of legal interpretation method can do especially related to the problems to be research possession transfer the sukuk savings to inheriting can postponement legacy effect which is not justified in islamic law or in the civil law.Keywords: state sukuk, savings sukuk, sukuk ownershipabstrakSalah satu instrumen dalam pasar modal syariah adalah sukuk(obligasi syariah).sukuk dapat dikeluarkan oleh perusahaan maupun negara. Saat ini ada 7 instrumen Sukuk Negara yg telah diterbitkan oleh Pemerintah, dua diantaranya ditujukan untuk investor individu Warga Negara Indonesia. Sukuk Negara untuk investor individu adalah sukuk ritel dan sukuk tabungan. Baik sukuk ritel maupun sukuk tabungan sama sama surat berharga syariah negara yang dikeluarkan untuk  mengajak masyarakat Indonesia berinvestasi dan membantu pembangunan negara karena hasil penjualan dari kedua sukuk ini akan digunakan sebagai pembangunan infrastruktur negara.namun salah satu perbedaan yang paling  mencolok dari kedua sukuk ini ialah sukuk ritel bersifat tradable (bisa dialihkan/diperdagangkan) sedangkan sukuk tabungan bersifat non-tradble(tidak dapat diperdagangkan/tidak bisa dialihkan).lantas bagaimana jika pemilik sukuk meninggal dunia apakah kepemilikan sukuk ini bisa dialihkan melalui pewarisan.  Metode yang digunakan dalam penelitian ini adalah statute approach dan Penelitian ini dalam konteks hukum menggunakan pendekatan penelitian hukum doktrinal, namun tidak menutup kemungkinan untuk dapat dilakukan metode interpretasi hukum terutama terkait dengan masalah yang akan diteliti.perlihan hak milik sukuk tabungan melalui pewarisan ini bisa mengakibatkan penundaan pewarisan yang mana hal ini tidak dibenarkan dalam hukum islam maupun dalam kitab undang-undang hukum perdata.Kata kunci:sukuk Negara,sukuk Tabungan,kepemilikan sukuk
Persekutuan Komanditer (Commanditaire Venootschap) Sebagai Pemegang Hak Guna Bangunan
Authors: Batubara Sonia Carolline , Kotan Geradin Mayella Jivisina , Hartono Rico Andrian
Published: November 2019

Penelitian ini bertujuan untuk mengetahui kepastian hukum atas pemberian status Hak Guna Bangunan kepada Persekutuan Komanditer (CV) berdasarkan Surat Edaran Nomor 2/SE-HT.02.01/VI/2019 Tentang Pemberian Hak Guna Bangunan untuk Persekutuan Komanditer (Commanditaire Vennootschap). Metode yang digunakan untuk mengkaji permasalahan yang akan dibahas menggunakan metode penelitian yuridis normatif yang merupakan penelitian kepustakaan dengan pengumpulan bahan-bahan hukum primer, sekunder dan tersier seperti buku-buku, karya ilmiah hukum, bahan-bahan tertulis lain yang memberikan penjelasan mengenai kajian yang akan dibahas. Jika dilihat dari kedudukan Surat Edaran dalam hirarkie perundang-undangan serta memperhatikan norma-norma yang tertuang di dalamnya maka pemberian Hak Guna Bangunan kepada CV bertentangan dengan aturan yang telah ada. Pemberian Hak Guna Bangunan kepada CV menurut Surat Edaran tersebut tidak memberikan kepastian hukum dan dapat dikategorikan sebagai perjanjian nominee.
Unpacking Scientific Competence for Effective Integration in the Curriculum Design
Authors: Napal Fraile María , Mendióroz Lacambra Ana María , Peñalva Vélez Alicia
Published: November 2019

Educating for Sustainability involves promoting sustainable competences in students. Not in vain, wider societal changes that ensure a balance between economic growth, respect for the environment and social justice must start with individual actions, implying knowledge, capacity and willingness to act. However, and although there is wide consensus that education should promote the development of competences for life, putting this theoretical tenet into may entail more problems. Competence is most often expressed in general terms without a specific definition of the intervening elements (knowledge, skills, values, attitudes), which may collide with the necessity of teachers – as learning planners - concrete entities on which to base their process of design. So that, in this work we propose a series of indicators that serve to characterize the four dimensions of scientific competence – contents of science, contents about science, value of science and utility of science-. Although they are primarily intended to be used to filter multimedia resources in an educational platform, this proposal of indicators can be extrapolated to the management and selection of a variety of resources and activities, and for sharing the objectives and evidences for the acquisition of competencies.
Design, Synthesis and Pharmacological Evaluation of Novel Annelated Pyrimido[2,1-c][1,2,4]Triazolo[3,4-f][1,2,4]Triazines as Antimicrobial Agents
Authors: El Azab Islam H. , Elkanzi Nadia A.A.
Published: November 2019

In our tactic to construct bio-active molecules, a series of novel pyrimido[2,1-c][1,2,4]triazine-3,4-diones based heterocycles, were synthesized and evaluated for their in vitro antimicrobial impacts. The exploratory bioassay results declared that, the majority of the evaluated compounds exhibited considerable anti-microbial activity comparable to the reference drugs. Conjugates 15j, 15f, 15i, 15h, 15g and 15a were found to be the most potent antibacterial, indicating that conjugates bearing electron-attracting substituents exhibited higher potency than these with electron-releasing substituents.
Nor-Lignans: Occurrence in Plants and Biological Activities - A Review
Authors: Frezza Claudio , Venditti Alessandro , Toniolo Chiara , De Vita Daniela , Franceschin Marco , Ventrone Antonio , Tomassini Lamberto , Foddai Sebastiano , Guiso Marcella , Nicoletti Marcello , Serafini Mauro , Bianco Armandodoriano
Published: November 2019

In this review article, the occurrence of nor-lignans and their biological activities are explored and described. Nor-lignans have proven to be present in several different families also belonging to chemosystematically distant orders as well as to have many different beneficial pharmacological activities. This review article represents the first one on this argument and is thought to give a first overview on these compounds with the hope that their study may continue if not raise after this.
Pengelolaan Pupuk Kandang Sapi Dalam Rangka Meningkatkan Mutu di Desa Jetis, Kecamatan Sambirejo, Kabupaten Sragen
Authors: Minardi Slamet , Suryono Suryono
Published: November 2019

Program PKM ini bekerjasama dengan dua mitra, yaitu: (1) Kelompok Ternak “Lembu Mulyo”, dan (2) Kelompok Ternak “Andini”. Mitra (1) dan Mitra (2) berlokasi di Desa Jetis, Kecamatan Sambirejo, Kabupaten Sragen, dengan jarak tempuh sekitar 39 km dari Fak. Pertanian UNS. Bidang usaha yang dikembangkan oleh kedua mitra tersebut adalah usaha peternakan sapi. Lokasi kedua mitra sangat berdekatan, hanya sekitar 1,2 km. Permasalahan dihadapi yaitu banyaknya kotoran sapi yang kurang bermutu dan kurang termanfaatkan, produksi limbah ternak sapi (kotoran sapi) yang sangat tinggi, yaitu sekitar 100 kg limbah per hari (3 ton per bulan) pada masing-masing mitra, dan jika hal ini dibiarkan akan menjadi tumpukan kotoran sapi yang sangat berbau yang mengganggu lingkungan. Kegiatan yang dilakukan meliputi: koordinasi dengan mitra dan pendampingan pengelolaan/pengolahan kotoran sapi melalui fermentasi yang diperkaya dengan bakteri perombak, yang dapat menambah ketersediaan N, K dan Ca sebagai pupuk organik yang sangat bermutu.
HEKİM İMAJINA YÖNELİK TOPLUMSAL ALGIYA DAİR BİR ARAŞTIRMA
Authors: METİN Aslı , ERDEM Ramazan
Published: November 2019

Bu
araştırma hekimlerin toplumsal imajlarına yönelik algıyı ölçmek amacıyla
yapılmıştır. Araştırmanın evrenini Isparta il merkezinde oturan ve sağlık
hizmetini en az bir kez kullanmış 18 yaş ve üzeri bireyler oluşturmaktadır.
Araştırma kapsamında 297 kişiye ulaşılmıştır. Araştırmada veri toplama aracı
olarak Çatı ve Öcel (2017) tarafından geliştirilmiş ve 33 ifadeden oluşan
“Algılanan Hekim İmajı Ölçeği” kullanılmıştır. Araştırma sonucunda toplumun hekime karşı
olan algısının farklı olduğu bununla birlikte, hekimlerin güvenilir ve inanılır
ancak maddi menfaatlerinin peşinde koşan, kibirli ve öfkeli olma gibi
olumsuzluklara sahip kişiler olduğu sonucuna varılmıştır. Aynı zamanda
hasta-hekim düzeyine ilişkin memnuniyetin hekimlere yönelik bu algıyla olumlu
veya olumsuz olarak değiştiği ortaya çıkmıştır.
AİLE ŞİRKETLERİNİN KURUMSALLAŞMASINDA İÇ KONTROL SİSTEMİNİN ARACI ETKİSİ: TRC3 BÖLGESİ ARAŞTIRMASI
Authors: Polat Erhan , GÜNEŞ Recep
Published: November 2019

Aile
şirketleri, ekonomik yapı içerisindeki payları nedeniyle ulusal ve uluslararası
alanda önemsenmektedirler. Sürdürülebilir aile şirketi olmanın temeli
kurumsallaşmaya dayanmaktadır. Kurumsallaşma, yapılması gereken işlemlerin
sistemli hale getirilmesinin kavramsal düzeyde ifadesidir. Kurumsallaşma
çabalarının yürütülmesi süreci ise kurumsal yönetim olarak ifade edilebilir.
Kurumsal yönetimin başarısı, menfaat sahiplerinin haklarını gözetmesini
sağlayan kurumsal yönetim ilkeleri ile bu süreci destekleyen kurumsal risk yönetimi
ve iç kontrol sistemlerine dayanmaktadır. Çalışmanın amacı, aile şirketlerinde
kurumsal yönetim ilkeleri ile kurumsal risk yönetimi ve iç kontrol sistemi
arasındaki ilişkilerin tespit edilmesidir. 
Çalışma kapsamında anket yöntemi uygulanmıştır. Anket çalışması için
TRC3 bölgesi; “Batman, Mardin, Siirt ve Şırnak” illerinde konumlanan aile
şirketleri esas alınmıştır. Ankete 93 adet şirket sahibi katılmıştır. Elde
edilen veriler SPSS 25,0 paket programı ile analiz edilmiştir. Araştırma
sonuçlarına göre, kurumsal yönetim ilkeleri, kurumsal risk yönetimi ve iç
kontrol sistemleri arasında ilişki tespit edilmiştir. Ayrıca iç kontrol
sisteminin kurumsal risk yönetimi ile kurumsal yönetim ilkeleri arasında aracı
rolünün olduğuna dair sonuç elde edilmiştir. Bununla birlikte şirket yapıları
ile kurumsal yönetim ilkeleri, kurumsal risk yönetimi ve iç kontrol sistemi
arasındaki farklılıkların olduğu tespit edilmiştir. Araştırmadan elde edilen
veriler ışığında aile şirketlerinin kurumsallaşma çabaları kapsamında kurumsal
yönetim ilkeleri, kurumsal risk yönetimi ve iç kontrol sistemi uygulamalarına
daha fazla yer vermeleri önerilmektedir.
ORTA GELİR TUZAĞI, NEDENLERİ VE ÇIKIŞ POLİTİKALARI
Authors: ALANCIOĞLU Erdal , ARSLAN İbrahim , BAYRAKTUTAN Yusuf
Published: November 2019

Bazı gelişmekte olan ülkelerin 2000’li yıllarda
sergilediği büyüme performansı, bu ülkelerin kişi başına düşen milli
gelirlerinin gelişmiş ekonomiler düzeyine yakınsamasını sağlamıştır. Ancak bu yakınsamanın,
yakalama düzeyine taşınması, orta gelir düzeyine yükselmiş ülkeler için
aşılması gereken yeni engellere takılmıştır. Tarihsel süreç içerisinde, çok az
sayıda orta gelirli ülke yüksek gelirli ekonomi grubuna girmeyi başarmıştır.Orta
gelirli ülkelerin neden yüksek gelirli ülke olmak için yeterli iktisadi
büyümeyi sürdüremedikleri sorusu, iktisat literatüründe nispeten yeni bir
kavram olan Orta Gelir Tuzağı (OGT) ile önemli bir tartışma/araştırma konusunu
beraberinde getirmiştir.

Bu çalışma, teorik ve
analitik literatürden yararlanarak düşük gelir grubundan orta gelir grubuna geçen,
ancak orta gelir düzeyinde uzun süre takılarak yüksek gelir grubuna geçmekte
zorlanan orta gelirli ülkeler için OGT’nin belirleyicilerini açıklamakta; OGT’den
korunma/çıkış bağlamında politika önerilerini ortaya koymaktadır.
GELİŞMİŞLİK DÜZEYLERİNDEKİ FARKLILIKLARA GÖRE DEMOKRASİNİN ENFLASYON ÜZERİNDEKİ ETKİSİ: BİR PANEL VERİ ANALİZİ
Authors: DEMİRHAN Banu , DEMİRHAN Erdal
Published: November 2019

Yüksek enflasyon oranı
ekonomi üzerindeki olumsuz etkilerine bağlı olarak gelişmekte olan ülkelerde ve
gelişmiş ülkelerde temel ekonomik sorunların başında gelmektedir. Bu ülkelerde yüksek
enflasyonla mücadeleye yönelik olarak daha çok maliye ve para politikaları
uygulanmaktadır. Ancak bu politikaların enflasyonu düşürmedeki etkisi enflasyonun
arkasındaki yapısal nedenler nedeniyle sınırlı kalmaktadır. Bu nedenlerin
başında yer alan demokrasi düşük enflasyon için önem arz etmektedir. Bu
çalışmanın amacı demokrasinin düşük enflasyona olan katkısını gelişmiş ve gelişmekte
olan ülkeler verileri yardımıyla incelemektir. Elde edilen bulgular gelişmiş
ülkelerde düşük enflasyonun sağlanmasında demokrasinin önemini ortaya
koymaktadır.
La traducción de léxico especializado en el cine de superhéroes: estudio de Avengers: Infinity War de Marvel Studios
Authors: Szymyslik Robert
Published: November 2019

El presente trabajo representa un análisis traductológico de una obra audiovisual perteneciente al género superheroico. En él se toma como base el estudio del trasvase de diferentes muestras de léxico especializado que se utiliza en esta producción. El largometraje elegido para ello es Avengers: Infinity War (Vengadores: Infinity War en España) de Marvel Studios, una de las películas más destacadas de esta clase de los últimos años y que ha conseguido críticas positivas tanto por parte de especialistas como del público. Este estudio se ha realizado llevando a término una comparación de extractos de la versión original del guion de la película (redactado en la lengua inglesa) y los diálogos de llegada doblados a la lengua española, traducidos por Quico Rovira-Beleta. Los diferentes ejemplos seleccionados de este largometraje se expondrán acompañados siempre de su contexto de procedencia tanto en su forma originaria como traducida y se llevarán a cabo análisis sobre cada uno de ellos por medio del sistema de la comparación contrastiva. Tras esto, se extraerán conclusiones acerca de las exigencias de documentación que muestra cada caso concreto, las técnicas de traducción que se han utilizado para trasladar el contenido entre idiomas y, por último, se estudiará la funcionalidad de cada uno de los equivalentes presentados en el nuevo contexto sociocultural.The following paper consists of the translation analysis of an audiovisual work belonging to the superhero genre. It is based on the study of the transference of different samples of specialised lexicon used in this product. The chosen movie to undertake this objective is Avengers: Infinity War (Vengadores: Infinity War in Spanish) by Marvel Studios, one of the most renowned films of this kind produced in recent years and that has received positive reviews from specialists as well as from the audience. The study has been completed by comparing the original version of the movie script (written in the English language) and the target dialogues transferred into Spanish, translated by Quico Rovira-Beleta. The different chosen examples from this movie will always be exposed along with their contexts of origin both in their original and their translated forms and each of them will be analyzed by means of a contrastive comparison system. After that, conclusions will be drawn about the documentation requirements of each specific example, the translation techniques that have been used to transport the content between the involved languages and, last but not least, the functionality in the new sociocultural context of each of the presented equivalents will be assessed.
Deciphering the transcriptomic response of Ilyonectria robusta in relation to Ginsenoside Rg1 treatment and the development of panax ginseng rusted root disease
Authors: Li Qiong , Xu Yonghua , Zhang Lianxue , Di Peng , Lu Baohui , Chen Changbao
Published: November 2019

Rust rot is a severe Panax ginseng disease caused by Ilyonectria robusta . The severity of the disease is related to the content of residual ginsenoside content in the soil. Herein, the effects of different concentrations of ginsenoside Rg1 on ginseng rust rot and its pathogens were studied, and the growth and sporulation of fungi cultured in vitro were determined. The results showed that Rg1 significantly promoted the mycelial growth, and sporulation compared to the control, and aggravated the disease symptoms of Panax ginseng . A total of 6,708 transcripts out of 213,131 annotated genes identified from global transcriptomic analysis were differentially expressed in I.robusta grown in the Rg1 treatment. These genes were found to be related to the carbon-nitrogen metabolism, transport, and assimilation. Many of these genes were also associated with pathogenicity based on the Phi-base database. Several transcription factors were related to specific biological processes, such as nitrogen utilization. The current results revelation that Rg1 plays a major role in the development of rust rot by promoting fungal cell growth and affecting the expression of genes required for pathogenesis. Rg1 could aggravate the invasion of I.robusta on ginseng root, which preliminarily revealed the reason for the aggravation of rust rot in ginseng c ontinuous cropping obstacle.
Lessons learned, challenges and outlooks for decision-making after a decade of experience monitoring the impact of Indoor Residual Spraying in Benin, West Africa
Authors: Akogbéto Martin C , Dagnon Fortuné , Aikpon Rock , OSSE Razaki , Salako Albert , AHOGNI Idelphonse , AKINRO Bruno , SOMINAHOUIN André , Sidick Aboubakar , Tokponnon Filémon , PADONOU Germain Gil
Published: November 2019

Background Since 2008, Indoor Residual Spraying (IRS) has been performed in Benin in 19 districts, including 4 in southern Benin, 9 in Atacora, and 8 in Atacora, Alibori and Donga in northern Benin. However, Benin still struggles with questions about IRS cost benefit and epidemiological impact. We discussed lessons learned and challenges from 10 years of IRS in Benin to be shared with the stakeholders involved in vector control implementation for decisions making. Methods We have assessed entomological parameters in IRS communes since 2008. In all IRS intervention communes, decreases in Human Biting Rate (HBR) of An. gambiae, blood feeding inhibition and Entomological Inoculation Rate (EIR) as compared to control district have been measured. Results EIR was reduced by 80-90%, which is encouraging, but should be observed with caution because: (i) the reduction may be insufficient to decrease epidemiological indicators given that the residual EIR in IRS districts is still higher than it is in some regions of stable malaria; (ii) the reduction in EIR is based on comparisons with control communes, but it is difficult to select control areas with the same environmental characteristics as intervention areas; (iii) despite the reduction, half of all mosquitoes that entered IRS-treated houses succeeded in taking human blood meals. Further, there are behaviors among Benin’s population that limit IRS efficacy, including recent data showing that >90% of people are not protected by IRS between 7-10 PM. This is due to the fact that they remain outside and that most people are not protected from mosquito bites after 10 PM because they either sleep outside without IRS protection or inside without an ITN. Moreover, people have large amounts of clothing hanging on walls where mosquitoes can rest instead of IRS-treated walls. Finally, other components are important to consider in implementing IRS among which: (i) Vector resistance management strategies are sometimes poorly understood; this is actually different from replacing an insecticide by another after the emergence of resistance; (ii) African countries should prepare to finance IRS themselves. Conclusion To curtail residual malaria transmission, additional interventions able to target vectors escaping IRS should be prioritized. Keywords: IRS, Lessons learned, challenges, outlooks, Benin
Generic Structure of Tourism Promotion Website of Madura Natural Wonders
Authors: Ekawati Rosyida , Puspitasari Desi
Published: November 2019

The research examined a genre-based analysis of a tourism promotion website of natural wonders on the official website of Sumenep regency. It used descriptive qualitative research. Source of the data was the Indonesian website of Sumenep regency on five natural wonders: they were tourism destinations in Gili Iyang, Gili Labak, Pantai Badur, Pantai Lombang, and Pantai Slopeng. Data collection was done by a classification of the move, step, and strategy that was proposed by Huang on sentence-based using Nvivo software. The findings yield from the proposed move and steps, and there are only four moves available compared to the proposed move and step. They comprise the move 1 headline, move 2 establishing credentials, move 3 directive information, move 4 soliciting response, and four steps in move 2 comprises step 1 introducing general situation, step 2 quoting literature, step 3 describing services or facilities, and step 4 describing critical attractions in the tourism promotion official website. The four moves found in official websites become obligatory because all moves are available in all contents of the tourism promotion website. The establishing credential move occupies the large portion of the website in giving information about the destination. Move 2 steps 2 quoting literature and move four could be categorized into non-obligatory moves because of those moves only available in one of the tourism promotions in the official website of Sumenep regency.
Students’ Perceptions on the Use of Google Docs as an Online Collaborative Tool in Translation Class
Authors: Sudrajat Winny Nur Ardy , Purnawarman Pupung
Published: November 2019

The research aimed at investigating students’ perceptions and experiences of using Google Docs in the translation class. Google Docs provided characteristics that can be used to promote peer interaction. However, the use of Google Docs as teaching and learning media was rarely conducted and still limited to teaching writing in Indonesia. Google Docs was commonly used by the translator to translate collaboratively, so the students worked together in a small group to solve and discuss the translation assignment by using some features through Google Docs. These activities were expected to enhance collaboration among them. This research employed a qualitative descriptive study as the research design. The questionnaire was used as the instrument to collect the data that involved fifty students (N = 50) as the participant. The results of this research show that students have a positive response to the use of Google Docs in translation class. It indicates that Google Docs is a suitable tool that can be used for educational purposes.
Information System Strategic Planning at PT EP-TEC Solutions Indonesia
Authors: Tirana Andry Adrian
Published: November 2019

This research aimed to analyze the internal and external environment of business and information system /information technology (IS/IT), to identify current and future application portfolios, and to develop an Information System Strategic Planning to achieve the vision, mission, and objectives of PT EP-TEC Solutions Indonesia. The data were obtained from the results of interviews, observations, literature study, questionnaires, and analysis of the company’s internal documents. Data were taken from interviewing and questionnaires that were ten managerial levels of 50 employees at PT EP-TEC Solutions Indonesia. The weight on the SWOT IFAS and EFAS matrix used a pairwise comparison method. The method applied descriptive method by using the Information System Strategic Planning framework from Ward and Peppard. The analytical tools used Porter’s Five Forces, PEST, SWOT, Value Chain, IT Balance Scorecard, and McFarlan Strategic Grid. The results of this research indicate that future application portfolio recommendation that supports SI business strategies, IS/IT management strategies, and IT strategies that can help PT EP-TEC Solutions Indonesia in achieving strategic goals. From these results, it can be concluded that there are several proposals for applications, security tools, profiles of knowledge and skills, and recommendations for IS/IT infrastructure that can be applied in the company.
Presencia y representación de las mujeres en el Congreso del Estado de Guanajuato
Authors: Góngora Cervantes Vanessa , Ramírez Barba Éctor Jaime , Martínez Tafolla Plinio Manuel E.
Published: November 2019

El artículo analiza la presencia y la representación de las mujeres en el Congreso del Estado de Guanajuato, México, de 1965 a 2018, por medio de una clasificación histórica que distingue cuatro etapas. El estudio toma en cuenta el número de diputadas en las Legislaturas, la participación, el cargo en Comisiones y la temática de las iniciativas de estas. Se determinan tres cortes temporales: 1965-1997 (representación simbólica), 1997-2015 (pequeña minoría con producción legislativa de género) y 2015-2018 (masa crítica consolidada). El valor del artículo consiste en el análisis histórico de la participación de las mujeres en el Congreso del Estado de Guanajuato desde la primera legisladora hasta la Legislatura 2015-2018. Se concluye que a partir de 1997 es notoria la presentación por parte de las legisladoras de asuntos de la agenda de mujeres y género en el Congreso del Estado de Guanajuato.
Movimiento social y apropiación indígena del conocimiento antropológico: la Escuela Nacional de Antropología e Historia en Oaxaca (1982-1993)
Authors: Maldonado Alvarado Benjamin
Published: November 2019

Este artículo evidencia la trascendencia que tuvo en Oaxaca la vinculación del pensamiento antropológico y el desarrollo magisterial de la educación indígena. Su base metodológica es testimonial-analítica; se revisaron archivos y recuerdos personales y documentos publicados por la Escuela Nacional de Antropología e Historia-Oaxaca. El texto recupera una parte de la historia ignorada de esta escuela, cuando en la década de 1980 abrió en Oaxaca una licenciatura para que se formaran maestros indígenas integrantes del recién iniciado movimiento democrático. La antropología crítica aportó miradas útiles para orientar la práctica docente y el movimiento social en que se inserta. El artículo contribuye a ver la antropología aplicada desde la antropología apropiada por indígenas movilizados. Se concluye que el cierre de la Escuela Nacional de Antropología e Historia-Oaxaca y la falta de titulación no impidieron que el conocimiento apropiado diera vida creciente a diversas propuestas y actividades sólidas en escuelas y comunidades indígenas desde 1993.