bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of mobile health on maternal and child health service utilization and continuum of care in Northern Ghana
Authors: Nuhu Abdul Ganiyu Kantamah , Dwomoh Duah , Amuasi Susan Ama , Dotse-Gborgbortsi Winfred , Kubio Chrysantus , Apraku Edward Anane , Timbire Jonas Kolong , Nonvignon Justice
Published: February 2023

Maternal and child mortality are of public health concern. Most of these deaths occur in rural communities of developing countries. Technology for maternal and child health (T4MCH) is an intervention introduced to increase Maternal and Child Health (MCH) services utilization and continuum of care in some health facilities across Ghana. The objective of this study is to assess the impact of T4MCH intervention on MCH services utilization and continuum of care in the Sawla-Tuna-Kalba District in the Savannah Region of Ghana. This is a quasi-experimental study with a retrospective review of records of MCH services of women who attended antenatal services in some selected health centers in the Bole (comparison district) and Sawla-Tuna-Kalba (intervention district) of the Savannah region, Ghana. A total of 469 records were reviewed, 263 in Bole and 206 in Sawla-Tuna-Kalba. A multivariable modified Poisson and logistic regression models with augmented inverse-probability weighted regression adjustment based on propensity scores were used to quantify the impact of the intervention on service utilization and continuum of care. The implementation of T4MCH intervention increased antenatal care attendance, facility delivery, postnatal care and continuum of care by 18 percentage points (ppts) [95% CI - 17.0, 52.0], 14 ppts [95% CI 6.0%, 21.0%], 27 ppts [95% CI 15.0, 26.0] and 15.0 ppts [95% CI 8.0, 23.0] respectively compared to the control districts. The study showed that T4MCH intervention improved antenatal care, skilled delivery, postnatal services utilization, and continuum of care in health facilities in the intervention district. The intervention is recommended for a scale-up in other rural areas of Northern Ghana and the West-African sub-region.
Butyrate limits human natural killer cell effector function
Authors: Zaiatz-Bittencourt Vanessa , Jones Fiona , Tosetto Miriam , Scaife Caitriona , Cagney Gerard , Jones Evan , Doherty Glen A. , Ryan Elizabeth J.
Published: February 2023

The gut microbiota regulates chronic inflammation and has been implicated in the pathogenesis of a broad spectrum of disease including autoimmunity and cancer. Microbial short-chain fatty acids (SCFAs) e.g., butyrate have demonstrated immunomodulatory effects and are thought to be key mediators of the host-microbiome interaction. Here, we investigated the effect of butyrate on effector functions of blood derived human NK cells stimulated for 18 h with a combination of IL-12/IL-15, a potent mix of cytokines that drive NK cell activation. We show that butyrate has a strong anti-inflammatory effect on NK cells. NK cells cultured in the presence of butyrate expressed lower levels of activating receptors (TRAIL, NKp30, NKp44) and produced lower levels of cytokines (IFNγ, TNF-α, IL-22, granzyme B, granzyme A, perforin) in response to IL-12/IL-15. Butyrate restricted NK cell function by downregulation of mTORC1 activity, c-Myc mRNA expression and metabolism. Using a shotgun proteomic approach, we confirmed the effect of butyrate on NK cell cytokine signaling and metabolism and identified BRD2, MAT2A and EHD1 as downstream mediators of these effects. This insight into the immunomodulatory activity of butyrate on human NK cell function might help to develop new ways to limit NK cell function during chronic inflammation.
Improvement of trip generation rates for mixed-use development in Klang Valley, Malaysia
Authors: Goh Boon Hoe , Yuen Choon Wah , Onn Chiu Chuen
Published: February 2023

Mixed-use developments (MXDs) are a single development project that integrates and interacts with different land uses. Traffic is estimated to be reduced with such development. However, there is no standard procedure is available to estimate the MXD trip generation rates in Malaysia. The Malaysian Trip Generation Manual (MTGM) is the guidelines currently been used to forecast future trips for single land use. If the trip generation rates for multiple land uses are summed as MXD trips, the total trips will be overestimated without considering the internal trip capture. This study aimed to establish an improved method for estimating the MXD trip generation rates. Four MXD observation sites were selected in Klang Valley. Traffic survey counts were conducted considering person-trip, including passengers in vehicles and pedestrians. The results revealed that the MXD trip generation rates with MTGM were higher than actual traffic counts during peak hours. The MXD adjustment factor was established as 0.63, which can be applied by multiplying the MTGM trip generation rates to reduce the generated MXD trips in PCU per hour. This research has formulated a new data collection method by integrating person counts, alongside with new guidelines for pedestrian counts. The findings provide an option to adjust the MXD trips and prevent from overestimating future trips, which may result in overdevelopment and spending on mitigation measures in urban planning and road infrastructure.
Development of Self-Active Aging Index (S-AAI) among rural elderly in lower northern Thailand classified by age and gender
Authors: Keeratisiroj Orawan , Kitreerawutiwong Nithra , Mekrungrongwong Sunsanee
Published: February 2023

This study aimed to develop a Self-Active Aging Index (S-AAI) for the rural community of Thailand using the World Health Organization (WHO) framework, and score it according to age and gender. Overall, 1,098 elderly people were randomly selected. The self-reported questionnaires were categorized into three segments: health, participation, and security according to the WHO framework. An exploratory factor analysis was used to determine appropriate components. The S-AAI comprised 28 indicators and 9 factors: (1) mental/subjective health; (2) physical health; (3) health behavior and chronic disease; (4) vision and hearing; (5) oral health; (6) social participation; (7) stability in life; (8) financial stability; and (9) secure living. The overall S-AAI for all components was 0.65, with the index inversely proportional to age, but with no gender differences. The S-AAI is potentially Thailand's first multi-dimensional interactive aging assessment tool with a unique cultural context for rural areas. Although this tool is valid, it requires reliability testing.
Application of a physiologically based pharmacokinetic model in predicting captopril disposition in children with chronic kidney disease
Authors: Khalid Sundus , Rasool Muhammad Fawad , Masood Imran , Imran Imran , Saeed Hamid , Ahmad Tanveer , Alqahtani Nawaf Shalih , Alshammari Fahad Ali , Alqahtani Faleh
Published: February 2023

Over the last several decades, angiotensin-converting enzyme inhibitors (ACEIs) have been a staple in the treatment of hypertension and renovascular disorders in children. One of the ACEIs, captopril, is projected to have all the benefits of traditional vasodilators. However, conducting clinical trials for determining the pharmacokinetics (PK) of a drug is challenging, particularly in pediatrics. As a result, modeling and simulation methods have been developed to identify the safe and effective dosages of drugs. The physiologically based pharmacokinetic (PBPK) modeling is a well-established method that permits extrapolation from adult to juvenile populations. By using SIMCYP simulator, as a modeling platform, a previously developed PBPK drug-disease model of captopril was scaled to renally impaired pediatrics population for predicting captopril PK. The visual predictive checks, predicted/observed ratios (ratiopred/obs), and the average fold error of PK parameters were used for model evaluation. The model predictions were comparable with the reported PK data of captopril in mild and severe chronic kidney disease (CKD) patients, as the mean ratiopred/obs Cmax and AUC0−t were 1.44 (95% CI 1.07 − 1.80) and 1.26 (95% CI 0.93 − 1.59), respectively. The successfully developed captopril-CKD pediatric model can be used in suggesting drug dosing in children diagnosed with different stages of CKD.
Exploring user experience and performance of a tedious task through human–agent relationship
Authors: Zhou Chao , Bian Yulong , Zhang Shu , Zhang Ziyang , Wang Yaoyuan , Liu Yong-Jin
Published: February 2023

Positive human–agent relationships can effectively improve human experience and performance in human–machine systems or environments. The characteristics of agents that enhance this relationship have garnered attention in human–agent or human–robot interactions. In this study, based on the rule of the persona effect, we study the effect of an agent’s social cues on human–agent relationships and human performance. We constructed a tedious task in an immersive virtual environment, designing virtual partners with varying levels of human likeness and responsiveness. Human likeness encompassed appearance, sound, and behavior, while responsiveness referred to the way agents responded to humans. Based on the constructed environment, we present two studies to explore the effects of an agent’s human likeness and responsiveness to agents on participants’ performance and perception of human–agent relationships during the task. The results indicate that when participants work with an agent, its responsiveness attracts attention and induces positive feelings. Agents with responsiveness and appropriate social response strategies have a significant positive effect on human–agent relationships. These results shed some light on how to design virtual agents to improve user experience and performance in human–agent interactions.
Predicting monthly hospital outpatient visits based on meteorological environmental factors using the ARIMA model
Authors: Bai Lu , Lu Ke , Dong Yongfei , Wang Xichao , Gong Yaqin , Xia Yunyu , Wang Xiaochun , Chen Lin , Yan Shanjun , Tang Zaixiang , Li Chong
Published: February 2023

Accurate forecasting of hospital outpatient visits is beneficial to the rational planning and allocation of medical resources to meet medical needs. Several studies have suggested that outpatient visits are related to meteorological environmental factors. We aimed to use the autoregressive integrated moving average (ARIMA) model to analyze the relationship between meteorological environmental factors and outpatient visits. Also, outpatient visits can be forecast for the future period. Monthly outpatient visits and meteorological environmental factors were collected from January 2015 to July 2021. An ARIMAX model was constructed by incorporating meteorological environmental factors as covariates to the ARIMA model, by evaluating the stationary $${R}^{2}$$

R

2

, coefficient of determination $${R}^{2}$$

R

2

, mean absolute percentage error (MAPE), and normalized Bayesian information criterion (BIC). The ARIMA $${(0, 1, 1) (0, 1, 0)}_{12}$$

(
0
,
1
,
1
)
(
0
,
1
,
0
)

12

model with the covariates of $$\text{SO}_{2}$$

SO
2

, $${PM}_{2.5}$$

PM

2.5

, and $$\text{CO}$$
CO
was the optimal model. Monthly outpatient visits in 2019 can be predicted using average data from past years. The relative error between the predicted and actual values for 2019 was 2.77%. Our study suggests that $$\text{SO}_{2}$$

SO
2

, $${PM}_{2.5}$$

PM

2.5

, and $$\text{CO}$$
CO
concentration have a significant impact on outpatient visits. The model built has excellent predictive performance and can provide some references for the scientific management of hospitals to allocate staff and resources.
Structural equation modeling of direct and indirect associations of social media addiction with eating behavior in adolescents and young adults
Authors: Mohsenpour Mohammad Ali , Karamizadeh Malihe , Barati-Boldaji Reza , Ferns Gordon A. , Akbarzadeh Marzieh
Published: February 2023

Social media (SM) exerts important effects on health-related behaviors such as eating behaviors (EB). The present study was designed to determine the direct and indirect association of SM addiction with EB in adolescents and young adults through body image (BI). In this cross-sectional study, 12–22 years old adolescents and young adults, with no history of mental disorders or psychiatric medications usage were studied through an online questionnaire shared via SM platforms. Data were gathered about SM addiction, BI, and EB in its sub-scales. A single approach and multi-group path analyses were performed to find possible direct and indirect associations of SM addiction with EB through BI concerns. Overall, 970 subjects, 55.8% boys, were included in the analysis. Both multi-group (β = 0.484, SE = 0.025, P < 0.001) and fully-adjusted (β = 0.460, SE = 0.026, P < 0.001) path analyses showed higher SM addiction is related to disordered BI. Furthermore, the multi-group analysis showed one unit increment in SM addiction score was associated with 0.170 units higher scores for emotional eating (SE = 0.032, P < 0.001), 0.237 for external stimuli (SE = 0.032, P < 0.001), and 0.122 for restrained eating (SE = 0.031, P < 0.001). The present study revealed that SM addiction is associated with EB both directly and also indirectly through deteriorating BI in adolescents and young adults.
Efficient and accurate KRAS genotyping using digital PCR combined with melting curve analysis for ctDNA from pancreatic cancer patients
Authors: Tanaka Junko , Nakagawa Tatsuo , Harada Kunio , Morizane Chigusa , Tanaka Hidenori , Shiba Satoshi , Ohba Akihiro , Hijioka Susumu , Takai Erina , Yachida Shinichi , Kamura Yoshio , Ishida Takeshi , Yokoi Takahide , Uematsu Chihiro
Published: February 2023

A highly sensitive and highly multiplexed quantification technique for nucleic acids is necessary to predict and evaluate cancer treatment by liquid biopsy. Digital PCR (dPCR) is a highly sensitive quantification technique, but conventional dPCR discriminates multiple targets by the color of the fluorescent dye of the probe, which limits multiplexing beyond the number of colors of fluorescent dyes. We previously developed a highly multiplexed dPCR technique combined with melting curve analysis. Herein, we improved the detection efficiency and accuracy of multiplexed dPCR with melting curve analysis to detectKRASmutations in circulating tumor DNA (ctDNA) prepared from clinical samples. The mutation detection efficiency was increased from 25.9% of the input DNA to 45.2% by shortening the amplicon size. The limit of detection of mutation was improved from 0.41 to 0.06% by changing the mutation type determination algorithm for G12A, resulting in a limit of detection of less than 0.2% for all the target mutations. Then, ctDNA in plasma from pancreatic cancer patients was measured and genotyped. The measured mutation frequencies correlated well with those measured by conventional dPCR, which can measure only the total frequency ofKRASmutants.KRASmutations were detected in 82.3% of patients with liver or lung metastasis, which was consistent with other reports. Accordingly, this study demonstrated the clinical utility of multiplex dPCR with melting curve analysis to detect and genotype ctDNA from plasma with sufficient sensitivity.
A novel transgenic mouse model expressing primate-specific nuclear choline acetyltransferase: insights into potential cholinergic vulnerability
Authors: AlQot H. E. , Rylett R. J.
Published: February 2023

The acetylcholine (ACh) synthesizing enzyme choline acetyltransferase (ChAT) is an important cholinergic neuronal marker whose levels and/or activity are reduced in physiological and pathological aging. One isoform of ChAT, 82-kDa ChAT, is expressed only in primates and found primarily in nuclei of cholinergic neurons in younger individuals, but this protein becomes mostly cytoplasmic with increasing age and in Alzheimer’s disease (AD). Previous studies suggest that 82-kDa ChAT may be involved in regulating gene expression during cellular stress. Since it is not expressed in rodents, we developed a transgenic mouse model that expresses human 82-kDa ChAT under the control of an Nkx2.1 driver. Behavioral and biochemical assays were used to phenotype this novel transgenic model and elucidate the impact of 82-kDa ChAT expression. The 82-kDa ChAT transcript and protein were expressed predominantly in basal forebrain neurons and subcellular distribution of the protein recapitulated the age-related pattern found previously in human necropsy brains. Older 82-kDa ChAT-expressing mice presented with better age-related memory and inflammatory profiles. In summary, we established a novel transgenic mouse expressing 82-kDa ChAT that is valuable for studying the role of this primate-specific cholinergic enzyme in pathologies associated with cholinergic neuron vulnerability and dysfunction.
The influence of the Asian summer monsoon on volcanic aerosol transport in the UTLS region
Authors: Wu Xue , Qiao Qi , Chen Bing , Wang Xin , Hoffmann Lars , Griessbach Sabine , Tian Yufang , Wang Yinan
Published: February 2023

This study analyses the influence of the Asian summer monsoon on volcanic aerosol transport. Realistic, altitude-resolved SO2emissions of a middle-latitude volcanic eruption (Sarychev 2009) and a tropical volcanic eruption (Nabro 2011) were retrieved and used to initialize the simulations of the long-range transport and dispersion of the sulfate aerosol plumes. The barrier effect of the Asian summer monsoon anticyclone (ASMA) isolated the Sarychev eruption plume outside of the ASMA but constrained the Nabro eruption plume inside of the ASMA, which is most evident in the UTLS region between isotropic surfaces of 360–420 K. Meanwhile, the ASMA could transport a fraction of the plume outside of ASMA quasi-horizontally to the tropical tropopause layer along the southeastern periphery of the anticyclonic circulation, and lift the volcanic plume inside the ASMA anticyclonically across the tropopause with an ascent rate of approximately 0.8 K/day. By enhancing the meridional transport in the UTLS region and lifting volcanic aerosols across the tropopause, the ASMA significantly expanded the potential effects of volcanic eruptions.
An ankylosaur larynx provides insights for bird-like vocalization in non-avian dinosaurs
Authors: Yoshida Junki , Kobayashi Yoshitsugu , Norell Mark A.
Published: February 2023

A voice box (larynx) is unique for tetrapods and plays functional roles in respiration, airway protection, and vocalization. However, in birds and other reptiles, the larynx fossil is extremely rare, and the evolution of this structure remains largely unknown. Here we report the fossil larynx found in non-avian dinosaurs from ankylosaur Pinacosaurus grangeri. The larynx of Pinacosaurus is composed of the cricoid and arytenoid like non-avian reptiles, but specialized with the firm and kinetic cricoid-arytenoid joint, prominent arytenoid process, long arytenoid, and enlarged cricoid, as a possible vocal modifier like birds rather than vocal source like non-avian reptiles. Although bird-unique vocal source (syrinx) have never been reported in non-avian dinosaurs, Pinacosaurus could have employed bird-like vocalization with the bird-like large, kinetic larynx. This oldest laryngeal fossil from the Cretaceous dinosaur provides the first step for understanding the vocal evolution in non-avian dinosaurs toward birds.
Two odorant receptors regulate 1-octen-3-ol induced oviposition behavior in the oriental fruit fly
Authors: Xu Li , Jiang Hong-Bo , Yu Jie-Ling , Pan Deng , Tao Yong , Lei Quan , Chen Yang , Liu Zhao , Wang Jin-Jun
Published: February 2023

The oriental fruit fly Bactrocera dorsalis (Hendel) is a notorious pest of fruit crops. Gravid females locate suitable oviposition sites by detecting host plant volatiles. Here, we demonstrate that 1-octen-3-ol, a volatile from mango, guides the oviposition behavior of female flies. Two odorant receptors (BdorOR7a-6 and BdorOR13a) are identified as key receptors for 1-octen-3-ol perception by qPCR analysis, heterologous expression in Xenopus laevis oocytes and HEK 293 cells followed by in vitro binding assays, as well as CRISPR/Cas9 genome editing in B. dorsalis. Molecular docking and site-directed mutagenesis are used to determine major binding sites for 1-octen-3-ol. Our results demonstrate the potential of 1-octen-3-ol to attract gravid females and molecular mechanism of its perception in B. dorsalis. BdorOR7a-6 and BdorOR13a can therefore be used as molecular targets for the development of female attractants. Furthermore, our site-directed mutagenesis data will facilitate the chemical engineering of 1-octen-3-ol to generate more efficient attractants.
A non-canonical sensing pathway mediates Plasmodium adaptation to amino acid deficiency
Authors: Marreiros Inês M. , Marques Sofia , Parreira Ana , Mastrodomenico Vincent , Mounce Bryan C. , Harris Chantal T. , Kafsack Björn F. , Billker Oliver , Zuzarte-Luís Vanessa , Mota Maria M.
Published: February 2023

Eukaryotes have canonical pathways for responding to amino acid (AA) availability. Under AA-limiting conditions, the TOR complex is repressed, whereas the sensor kinase GCN2 is activated. While these pathways have been highly conserved throughout evolution, malaria parasites are a rare exception. Despite auxotrophic for most AA, Plasmodium does not have either a TOR complex nor the GCN2-downstream transcription factors. While Ile starvation has been shown to trigger eIF2α phosphorylation and a hibernation-like response, the overall mechanisms mediating detection and response to AA fluctuation in the absence of such pathways has remained elusive. Here we show that Plasmodium parasites rely on an efficient sensing pathway to respond to AA fluctuations. A phenotypic screen of kinase knockout mutant parasites identified nek4, eIK1 and eIK2—the last two clustering with the eukaryotic eIF2α kinases—as critical for Plasmodium to sense and respond to distinct AA-limiting conditions. Such AA-sensing pathway is temporally regulated at distinct life cycle stages, allowing parasites to actively fine-tune replication and development in response to AA availability. Collectively, our data disclose a set of heterogeneous responses to AA depletion in malaria parasites, mediated by a complex mechanism that is critical for modulating parasite growth and survival.
Probing the composition dependence of residual stress distribution in tungsten-titanium nanocrystalline thin films
Authors: Sinojiya Rahulkumar Jagdishbhai , Paulachan Priya , Chamasemani Fereshteh Falah , Bodlos Rishi , Hammer René , Zálešák Jakub , Reisinger Michael , Scheiber Daniel , Keckes Jozef , Romaner Lorenz , Brunner Roland
Published: February 2023

Nanocrystalline alloy thin films offer a variety of attractive properties, such as high hardness, strength and wear resistance. A disadvantage is the large residual stresses that result from their fabrication by deposition, and subsequent susceptibility to defects. Here, we use experimental and modelling methods to understand the impact of minority element concentration on residual stresses that emerge after deposition in a tungsten-titanium film with different titanium concentrations. We perform local residual stress measurements using micro-cantilever samples and employ machine learning for data extraction and stress prediction. The results are correlated with accompanying microstructure and elemental analysis as well as atomistic modelling. We discuss how titanium enrichment significantly affects the stress stored in the nanocrystalline thin film. These findings may be useful for designing stable nanocrystalline thin films.
Simultaneous enrichment optimization of glycopeptides and phosphopeptides with the highly hydrophilic DZMOF-FDP
Authors: Zhou Xiaoyu , Zhang Hongyan , Wang Li , Lv Liting , Wu Ren'an
Published: February 2023

An approach for simultaneous enrichment of N-glycopeptides, mono- and multi-phosphopeptides was developed based on a multi-functional DZMOF-FDP material that provides multiple interactions of HILIC, IMAC, and MOAC.
Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance
Authors: Garcia-Chica Jesús , Paraiso West Kristian Dizon , Zagmutt Sebastián , Fosch Anna , Reguera Ana Cristina , Alzina Sara , Sánchez-García Laura , Fukushima Shigeto , Toh Kazuko , Casals Núria , Serra Dolors , Herrero Laura , Garcia Jordi , Kataoka Kazunori , Ariza Xavier , Quader Sabina , Rodríguez-Rodríguez Rosalía
Published: February 2023

Targeting brain lipid metabolism using polymeric-based nanomedicine is a promising strategy to regulate the energy balance and fight metabolic diseases such as obesity.
A separable nanodevice enables multilayer imaging of diverse biomarkers for precise diagnosis
Authors: Yu Sha , Sun Yao , Cai Jingyi , Zhou Yuanzhen , Zhu Jun-Jie
Published: February 2023

An acid-driven separable nanodevice based on a pH-sensitive structure and the like-catalytic hairpin assembly-assisted target amplification strategy for in situ multilayer imaging of extracellular pH and cytoplasmic miR-125a with high sensitivity.
Axial optimization of biomimetic nanoenzyme catalysts applied to oxygen reduction reactions
Authors: Liu Jingjing , Jia Jingjing , Wen Huiying , Li Siqi , Wu Yingjie , Wang Qi , Kan Ziwang , Li Yan , Wu Xia , Zhao Jingxiang , Liu Song , Li Bin
Published: February 2023

A typical synthesis of the FeN4X-SAzyme (x = F, Cl, Br, I) is based on high-temperature pyrolysis. The results showed that the chlorine-coordinated monatomic iron material (FeN4Cl-SAzyme) was a promising catalyst for the oxygen reduction reaction.
From electronic structure to model application for alkyl cyclohexane combustion chemistry: H-atom abstraction reactions by HȮ2radical
Authors: Liu Mingxia , Hui Xin , Xue Xin , Lin Yuzhen , Zhou Chong-Wen
Published: February 2023

High-levelab initiocalculations on rate constants and thermochemistry for the reactions of alkyl cyclohexanes + HȮ2were carried out and the results can be employed in chemical kinetics model development for alkyl cyclohexane combustion.
Optical trapping and light scattering in atmospheric aerosol science
Authors: Rafferty Aidan , Vennes Benjamin , Bain Alison , Preston Thomas C.
Published: February 2023

Light scattering from an optically trapped particle can be used to study various processes and physical properties of atmospheric aerosol.
Superconducting H7 chain in gallium hydrides at high pressure
Authors: Liu Meixu , Cui Wenwen , Shi Jingming , Hao Jian , Li Yinwei
Published: February 2023

Evolution of superconductivity for GaH7 as a function of pressure.
High entropy alloy nanoparticles encapsulated in graphitised hollow carbon tubes for oxygen reduction electrocatalysis
Authors: Yao Yuechao , Li Zhangjian , Dou Yibo , Jiang Tao , Zou Jizhao , Lim Sung Yul , Norby Poul , Stamate Eugen , Jensen Jens Oluf , Zhang Wenjing
Published: February 2023

High entropy alloys (HEAs) are encapsulated in graphitized hollow carbon tubes to confine the growth of alloy particles during the formation process. Zinc–air batteries with HEAs as air electrodes exhibit long-lasting durability and high efficiency.
Molecular brush: an ion-redistributor to homogenize fast Zn2+flux and deposition for calendar-life Zn batteries
Authors: Liu Huanyan , Ye Qian , Lei Da , Hou Zhidong , Hua Wei , Huyan Yu , Li Na , Wei Chunguang , Kang Feiyu , Wang Jian-Gan
Published: February 2023

A surface-grafting strategy of molecular brushes is demonstrated to create a robust ion-regulating interface toward calendar-life Zn anodes with a high Coulombic efficiency of 99.9% and ultralong cyclability over 2500 h at 10 mA cm−2.
An amendedin vitro–in vivoextrapolation model that accounts for first pass clearance effects on chemical bioaccumulation in fish
Authors: Saunders Leslie J. , Nichols John W. , Arnot Jon A. , Armitage James M. , Wania Frank
Published: February 2023

An amendedin vitro–in vivoextrapolation model that accounts for first pass clearance effects on chemical bioaccumulation in fish. Pre-systemic biotransformation can significantly reduce chemical oral bioavailability, which can reduce dietary chemical bioaccumulation potential.
Oolong tea of different years protects high-fat diet-fed mice against obesity by regulating lipid metabolism and modulating the gut microbiota
Authors: Fang Wen-wen , Wang Kuo-fei , Zhou Fang , Ou-yang Jie , Zhang Zi-ying , Liu Chang-wei , Zeng Hong-zhe , Huang Jian-an , Liu Zhong-hua
Published: February 2023

Long-term stored oolong tea has recently attracted considerable attention concerning its salutary effect.
Combining eutectic solvents and pressurized liquid extraction coupled in-line with solid-phase extraction to recover, purify and stabilize anthocyanins from Brazilian berry waste
Authors: de Souza Mesquita Leonardo M. , Contieri Letícia S. , Sosa Filipe H. B. , Pizani Rodrigo S. , Chaves Jaisa , Viganó Juliane , Ventura Sónia P. M. , Rostagno Maurício A.
Published: February 2023

A PLE-SPE extraction process for the anthocyanins from Jabuticaba wastes was developed using an eutectic mixture, this acting simultaneously as solvent and stabilizing agent.
Efficient and robust image registration for two-dimensional micro-X-ray fluorescence measurements
Authors: Bock Felix , Gruber Andreas , Leopold Kerstin , Bruhn Henning
Published: February 2023

Solving image registration problem in micro-X-ray uorescence spectrometry (µ-XRF) is a first step towards application of multi-image super-resolution technique.
Utilization of γ-radiation in the synthesis of bimetallic Cu–Ni catalysts for selective vapour phase hydrogenation of levulinic acid to γ-valerolactone
Authors: Babu Gadamani Suresh , Francis Sanju , Padmakar Dasari , Rajitha Paka , Subrahamanyam Challapalli , Lingaiah Nakka
Published: February 2023

A set of mono and bimetallic Cu–Ni systems supported on γ-alumina catalysts were synthesized using γ-radiation instead of conventional calcination and reduction.
Janus β-PdXY (X/Y = S, Se, Te) materials with high anisotropic thermoelectric performance
Authors: Jakhar Mukesh , Sharma Raman , Kumar Ashok
Published: February 2023

Two-dimensional (2D) materials have garnered considerable attention as emerging thermoelectric (TE) materials owing to their unique density of states (DOS) near the Fermi level.
Plasma-jet printing of colloidal thermoelectric Bi2Te3 nanoflakes for flexible energy harvesting
Authors: Manzi Jacob , Weltner Ariel E. , Varghese Tony , McKibben Nicholas , Busuladzic-Begic Mia , Estrada David , Subbaraman Harish
Published: February 2023

Bi2Te3 nanoplates were synthesized to develop a water-based nanomaterial ink for a gravity-independent method of additive manufacturing. By optimization of the plasma-jet printer, deposited N-type thermoelectric legs showed significant flexibility.
Pressure-induced distinct excitonic properties of 2D perovskites with isomeric organic molecules for spacer cations
Authors: Wang Qingya , Ding Huafeng , Yang Tieshan , Xu Qinfeng , Mu Haifeng , Lu Taiping , Jiao Mengmeng , Zhang Jie , Cao Kunjian , Li Zhigang , Wang Honggang , Zhang Shufang , Wang Kai , Yang Chuanlu
Published: February 2023

The evolution of the structural and photoluminescence (PL) properties of [CH3(CH2)4NH3]2PbI4 ((PA)2PbI4) and [(CH3)2CH(CH2)2NH3]2PbI4 ((PNA)2PbI4) with isomeric organic molecules for spacer cations.
Flexibility-driven 1D-structural preference in a bis-terpyridine-Fe(ii)-metallo-supramolecular polymer possessing potential tricolor electrochromism
Authors: Tripathi Shivani , Halder Sayan , Prusti Banchhanidhi , Chakraborty Chanchal , Chakravarty Manab
Published: February 2023

We report a flexible and electron-rich N-hexyldiphenylamine-based angular ditopic terpyridine ligand that contrarily affords a 1-D linear metallosupramolecular polymer, exhibiting tricolour electrochromism with decent colouration efficiency.
Pursuing high efficiency in photocatalytic oxidative couplings of heteroarenes and aliphatic C–H bonds
Authors: Zhang Luoqiang , Zhu Dao-Yong , Hu Jingyao , Feng Minjun , Sum Tze Chien , Sun Haoran , Hirao Hajime , Chi Yonggui Robin , Zhou Jianrong Steve
Published: February 2023

Azole and azine heteroarenes were directly alkylated by alkanes, ethers, or carbamates using PhC(O)O2tBu under LED irradiation. 9,10-Dichloroanthrocene acted as an organic photocatalyst and transferred its excitation energy to PhC(O)O2tBu via exciplex formation.
Beliefs versus resources: a tale of two models of epistemology
Authors: DeGlopper Kimberly S. , Russ Rosemary S. , Sutar Prayas K. , Stowe Ryan L.
Published: February 2023

Compelling evidence, from multiple levels of schooling, suggests that teachers’ knowledge and beliefs about knowledge, knowing, and learning (i.e., epistemologies) play a strong role in shaping their approaches to teaching and learning. Given the importance of epistemologies in science teaching, we as researchers must pay careful attention to how we model them in our work. That is, we must work to explicitly and cogently develop theoretical models of epistemology that account for the learning phenomena we observe in classrooms and other settings. Here, we use interpretation of instructor interview data to explore the constraints and affordances of two models of epistemology common in chemistry and science education scholarship: epistemological beliefs and epistemological resources. Epistemological beliefs are typically assumed to be stable across time and place and to lie somewhere on a continuum from “instructor-centered” (worse) to “student-centered” (better). By contrast, a resources model of epistemology contends that one's view on knowledge and knowing is compiled in-the-moment from small-grain units of cognition called resources. Thus, one's epistemology may change one moment to the next. Further, the resources model explicitly rejects the notion that there is one “best” epistemology, instead positing that different epistemologies are useful in different contexts. Using both epistemological models to infer instructors’ epistemologies from dialogue about their approaches to teaching and learning, we demonstrate that how one models epistemology impacts the kind of analyses possible as well as reasonable implications for supporting instructor learning. Adoption of a beliefs model enables claims about which instructors have “better” or “worse” beliefs and suggests the value of interventions aimed at shifting toward “better” beliefs. By contrast, modeling epistemology as in situ activation of resources enables us to explain observed instability in instructors’ views on knowing and learning, surface and describe potentially productive epistemological resources, and consider instructor learning as refining valuable intuition rather than “fixing” “wrong beliefs”.
BINOL-like atropisomeric chiral nanographene
Authors: Li Shengtao , Li Ranran , Zhang Yi-Kang , Wang Shutao , Ma Bin , Zhang Bin , An Peng
Published: February 2023

A novel BINOL-like chiral nanographene was prepared with good yield. Unlike most helicity-based nanographenes, this chirality of the nanographene purely stems from an axial chirality.
Experimental and theoretical elucidation of SPAAC kinetics for strained alkyne-containing cycloparaphenylenes
Authors: Fehr Julia M. , Myrthil Nathalie , Garrison Anna L. , Price Tavis W. , Lopez Steven A. , Jasti Ramesh
Published: February 2023

Strained alkyne-containing cycloparaphenylenes unite curved carbon nanomaterials with tunable reactivity via physical organic chemistry. Herein we describe the rational design and synthesis of new derivatives with heightened SPAAC reactivity.
Non-collinear magnetism in the post-perovskite thiocyanate frameworks CsM(NCS)3
Authors: Geers Madeleine , Lee Jie Yie , Ling Sanliang , Fabelo Oscar , Cañadillas-Delgado Laura , Cliffe Matthew J.
Published: February 2023

The synthesis, structure and magnetic properties of the layered molecular post-perovskites CsM(NCS)3 M = Ni, Mn, Co, are reported. Neutron diffraction and bulk magnetometry show these isomorphic compounds order with different complex non-collinear magnetic structures.
Real-time monitoring of the sialic acid biosynthesis pathway by NMR
Authors: Gorenflos López Jacob L. , Schmieder Peter , Kemnitz-Hassanin Kristin , Asikoglu Hatice Ceyda , Celik Arif , Stieger Christian E. , Fiedler Dorothea , Hinderlich Stephan , Hackenberger Christian P. R.
Published: February 2023

From chemical shifts to conversion velocity: real-time NMR spectroscopy using a combination of 1D and 2D experiments can monitor individual enzymatic steps in the sialic acid biosynthesis pathway in rat liver cytosolic extract.
Unveiling a high capacity multi-redox (Nb5+/Nb4+/Nb3+) NASICON-Nb2(PO4)3 anode for Li- and Na-ion batteries
Authors: Patra Biplab , Kumar Keshav , Deb Debolina , Ghosh Subham , Gautam Gopalakrishnan Sai , Senguttuvan Premkumar
Published: February 2023

Sodium superionic conductor (NASICON)-type materials are widely explored as Li- and Na-ion cathodes and solid-state electrolytes but are largely ignored as anodes due to their lower capacities and higher intercalation voltages, which reduce the overall energy densities of Li- and Na-ion batteries (LIBs and SIBs).
DMAI-driven all-inorganic antimony-based perovskite-inspired solar cells with record open-circuit voltage
Authors: Guo Yixin , Zhao Fei , Yang Peizhi , Gao Minjie , Shen Junhao , Tao Jiahua , Jiang Jinchun , Chu Junhao
Published: February 2023

In this work, low-cost inorganic antimony-based perovskite-inspired solar cells with the co-assistance of DMAI and RbCl are constructed. The resulting device achieves a relatively high efficiency of 3.37% with a record open-circuit voltage of 0.93 V.
Simultaneous tailoring of hydrogen evolution and dendrite growthviaa fertilizer-derived additive for the stabilization of the zinc anode interface
Authors: Shaik Mahammad Rafi , Olidan Syryll Maynard , Kim Jihoon , Cho Kuk Young , Yoon Sukeun
Published: February 2023

A highly effective strategy to regulate Zn nucleation and suppress hydrogen evolution in Zn-ion batteries using a fertilizer-derived additive is reported. Mechanism by which the fertilizer-derived additive modulates the Zn interface.
Armoring a liposome-integrated tissue factor with sacrificial CaCO3 to form potent self-propelled hemostats
Authors: Liu Chengkun , Shi Zhuang , Zhu Jingyan , Liu Chang , Liu Xiaodan , Khan Naseer Ullah , Liu Shihai , Wang Xiaojuan , Wang Xiaoqiang , Huang Fang
Published: February 2023

A self-propelled nanoparticle system composed of a tissue factor (TF) integrated into a liposome and a CaCO3 shell was developed, showing superior hemostatic capacity by delivering the lipidated TF deep into bleeding wounds with good biocompatibility.
Cross-linkable star-hyperbranched unimolecular micelles for the enhancement of the anticancer activity of clotrimazole
Authors: Gosecki Mateusz , Ziemczonek Piotr , Gosecka Monika , Urbaniak Malgorzata , Wielgus Ewelina , Marcinkowska Monika , Janaszewska Anna , Klajnert-Maculewicz Barbara
Published: February 2023

We have shown that clotrimazole formulations encapsulated in polyether-based unimolecular micelles have significantly higher antitumour activity than the drug itself.
Magnetic enhanced high-efficiency electromagnetic wave absorbing MXene/Fe3O4 composite absorbers at 2–40 GHz
Authors: Wang Yan , Zhang Haiyan , Wu Qibai , Li Shengkai , Gao Heng , Wan Baoshan , Wen Daofeng , Zeng Guoxun
Published: February 2023

The sandwich-like MXene composites decorated with Fe3O4 nanoparticles have been prepared to improve the electromagnetic attenuation performance between 2 and 40 GHz. The RLmin can be up to −66.25 dB, and the EAB can be up to 8.49 GHz.
In-source fragmentation of nucleosides in electrospray ionization towards more sensitive and accurate nucleoside analysis
Authors: Chen Yu-Nan , Shen Xu-Yang , Yu Yue , Xue Chen-Yu , Zhou Ying-Lin , Zhang Xin-Xiang
Published: February 2023

The mechanism of in-source nucleoside fragmentation in ESI-MS was revealed, leading to nucleoside analysis with an enhanced response and less ambiguity.
Recent advances in hydrogels for preventing tumor recurrence
Authors: Qian Qiuhui , Song Jie , Chen Chen , Pu Qian , Liu Xingcheng , Wang Huili
Published: February 2023

The common skeletons and formulations of hydrogels for tumor recurrence are summarized. The review emphasizes unique properties of hydrogels for postoperative tumor prevention and provides a broader insight into clinical transformation of hydrogels.
Structural optimization of BODIPY photosensitizers for enhanced photodynamic antibacterial activities
Authors: Wen Hui , Wu Qihang , Liu Liqian , Li Yite , Sun Tingting , Xie Zhigang
Published: February 2023

4 BODIPYs with different functional groups have been developed and their photodynamic antibacterial activities are comprehensively studied and compared.
In situ reduction of Cu nanoparticles on Mg-Al-LDH for simultaneous efficient catalytic transfer hydrogenation of furfural to furfuryl alcohol
Authors: Pan Ganen , Cheng Shifang , Zhang Yingxue , Chen Yakai , Xu Xingliang , Xu Jing
Published: February 2023

In situ reduction of Cu nanoparticles on Mg-Al-LDH and hydrogenation of furfural to furfuryl alcohol are carried out in one pot.
Two-dimensional XY ferromagnetism above room temperature in Janus monolayer V2XN (X = P, As)
Authors: Wan Wenhui , Fu Botao , Liu Chang , Ge Yanfeng , Liu Yong
Published: February 2023

This paper reported that monolayer V2XN (X = P and As) exhibits 2D-XY ferromagnetism with transition temperature above room temperature.
Coordination of sorbitol to Ga(OTf)3 in the liquid phase: an experimental and theoretical study
Authors: Li Mei , Xiong Jin-Shan , Min Han-Yun , Hu Ye-Xin , Zhu Liang-Fang , Hu Chang-Wei , Yang Hua-Qing
Published: February 2023

In a solution of sorbitol (SBT) and Ga(OTf)3 compounds, the Ga3+ cation tends to form five six-coordination complexes, i.e., [Ga(η2O,O-OTf)3], [Ga(η3O2–O4-SBT)2]3+, [(η2O,O-OTf)Ga(η4O2–O5-SBT)]2+, [(η1O-OTf)(η2O2,O4-SBT)Ga(η3O3–O5-SBT)]2+, and [(η1O-OTf)(η2O,O-OTf)Ga(η3O3–O5-SBT)]+.
A highly accurate full-dimensional ab initio potential surface for the rearrangement of methylhydroxycarbene (H3C–C–OH)
Authors: Wang Heng-Ding , Fu Yan-Lin , Fu Bina , Fang Wei , Zhang Dong H.
Published: February 2023

A highly accurate full-dimensional machine learning global potential energy surface for the rearrangement of methylhydroxycarbene (MHC, H3C–C–OH) was constructed, and the decay rate of MHC was evaluated with instanton rate theory based on this PES.
Peroxidase-like activity of hollow sphere-like FeS2/SC boosted by synergistic action of defects and S–C bonding
Authors: Tan Hao , Nan Zhaodong
Published: February 2023

A hollow sphere-like composite composed of pyrite FeS2 and sulfur-doped hollow sphere-shaped carbon was synthesized, which was used to detect Cys as a nanozyme.
Reactivity of triphosphinoboranes towards H3B·SMe2: access to derivatives of boraphosphacycloalkanes with diverse substituents
Authors: Ordyszewska Anna , Chojnacki Jarosław , Grubba Rafał
Published: February 2023

Reactions of triphosphinoboranes with borane dimethylsulfide provided access to boraphosphacycloalkanes with diverse structures.
One-pot terpolymerization of CHO, CO2andl-lactide using chloride indium catalysts
Authors: Martínez de Sarasa Buchaca Marc , de la Cruz-Martínez Felipe , Sánchez-Barba Luis F. , Tejeda Juan , Rodríguez Ana M. , Castro-Osma José A. , Lara-Sánchez Agustín
Published: February 2023

Ring-opening copolymerization reactions of epoxides, carbon dioxide and cyclic esters to produce copolymers is a promising strategy to prepare CO2-based polymeric materials.
Fabricating liquid crystal vitrimer actuators far below the normal processing temperature
Authors: Yao Yanjin , He Enjian , Xu Hongtu , Liu Yawen , Wei Yen , Ji Yan
Published: February 2023

We find that some liquid crystal vitrimers can be fabricated into actuators at a temperature below the topology freezing transition temperature (Tv) even though it is widely regarded that such fabrications should always be carried out well above theTv.
Locally implantable nanofibre meshes by sustained release of temozolomide for combined thermo-chemotherapy to treat glioblastoma
Authors: Oe Emiho , Fujisawa Nanami , Chen Lili , Uto Koichiro , Matsumoto Yoshitaka , Ebara Mitsuhiro
Published: February 2023

This study investigates nanofibre meshes that enable the long-term release of temozolomide (TMZ) over a 4 week period and the combinated therapy of hyperthermia/chemotherapy to treat glioblastoma.
Gas-to-nanotextile: high-performance materials from floating 1D nanoparticles
Authors: Gómez-Palos Isabel , Vazquez-Pufleau Miguel , Schäufele Richard S. , Mikhalchan Anastasiia , Pendashteh Afshin , Ridruejo Álvaro , Vilatela Juan J.
Published: February 2023

Suspended in the gas phase, 1D inorganic nanoparticles (nanotubes and nanowires) grow to hundreds of microns in a second and can be thus directly assembled into freestanding network materials.
Cobalt–platinum intermetallic composite loaded on pyridinic N-enriched carbon for acidic hydrogen evolution catalysis with ultralow overpotential
Authors: Xie Qiushi , Li Jiankun , Wang Keyu , Li Shiyi , Xu Weiyi , Wang Yixing , Lei Linfeng , Li Siyao , Zhuang Linzhou , Xu Zhi
Published: February 2023

Ar-calcined NCS-CoPt shows a robust HER activity owing to its highly active CoPt3 sites and pyridinic N enriched carbon nanosheets.
Investigation of structural, opto-electronic and thermoelectric properties of titanium based chloro-perovskites XTiCl3 (X = Rb, Cs): a first-principles calculations
Authors: Khan Naimat Ullah , Abdullah  , Khan Umar Ayaz , Tirth Vineet , Al-Humaidi Jehan Y. , Refat Moamen S. , Algahtani Ali , Zaman Abid
Published: February 2023

Perovskites are a significant class of materials with diverse uses in modern technology.
Ruthenium-catalyzed hydroarylation reactions as the strategy towards the synthesis of alkylated arenes and substituted alkenes
Authors: Thowfik Salam , Afsina C. M. A. , Anilkumar Gopinathan
Published: February 2023

Metal catalyzed hydroarylation reactions achieve C–C or C-heteroatom bonds in an atom economical and step economical manner. Here we cover the literature from 2016 to 2022 to summarize the recent advancements in Ru-catalyzed hydroarylation reactions of alkenes and alkynes.
Recovery of vanadium and nickel from heavy oil fly ash (HOFA): a critical review
Authors: Bakkar Ashraf , El-Sayed Seleman Mohamed M. , Zaky Ahmed Mohamed M. , Harb Saeed , Goren Sami , Howsawi Eskander
Published: February 2023

Overall flowchart of the recovery of V and Ni from HOFA showing the most common steps following the main three optional leaching approaches.
Asymmetric and zwitterionic Blatter diradicals
Authors: Miao Fang , Ji Yu , Han Bo , Quintero Sergio Moles , Chen Hanjiao , Xue Guodong , Cai Lulu , Casado Juan , Zheng Yonghao
Published: February 2023

Asymmetric diradical molecular systems with different resonance mechanisms are largely unexplored. Two conjugated asymmetric diradicals with Blatter and phenoxyl moieties (pBP and mBP) have been synthesized and studied in depth.
Photo-response modulation of organic transistors for multi-level light sensing using active layer microstructure control
Authors: Park Dohyeong , Tarsoly Gergely , Kwon Dongyub , Shin Tae Joo , Pyo Seungmoon
Published: February 2023

The annealing processes lead to significant changes in microstructure of organic active layers and the effect of the film morphology on the photo-response characteristics of phototransistors is investigated.