bluuebunny/crossref_metadata_2025 huggingface dataset:
Apatite as an Indicator for the Formation of PGE Mineralization as Exemplified by Anorthosites of the Kievey Deposit, Fedorova-Pana Layered Complex, Kola Peninsula, Russia
Authors: Sushchenko Artyom , Groshev Nikolay , Rundkvist Tatyana , Kompanchenko Alena , Savchenko Yevgeny
Published: November 2023

This paper presents petrography, X-ray electron probe energy-dispersive (EDS), laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS), and Raman spectroscopy data to characterize the mineral associations and composition of apatite group minerals from anorthosites of the Kievey deposit, North platinum group-element (PGE) Reef, Fedorova-Pana Complex, Kola Peninsula, Russia. The mineralized coarse-grained anorthosite belongs to the most common rock type of the main ore body, and hosts irregular interstitial sulfide disseminations of 5–7 vol.%. Apatite in the anorthosite occurs as (a) euhedral grains included in the marginal parts of cumulus plagioclase laths, and (b) xenomorphic grains associated with intercumulus minerals. The composition of apatite evolves along a narrow trend from fluorapatite to hydroxylapatite. The F content of apatite reaches 2.21 wt.%; the maximum Sr and rare earth element (REE) concentrations are 257 and 5623 ppm, respectively, while the average ratio of La/YbN = 11.78, Sr/Sr* = 0.01, and Eu/Eu* = 0.06. Compared to classic PGE reefs in layered intrusions, such as Bushveld in South Africa and Stillwater in the United States, the mineralized anorthosite is distinguished by apatite with an unusually low chlorine concentration of only 0.46 wt.%. A suggested reason for this difference is the percolating nature of sulfide liquid, which has not been enriched in PGE in situ.
Preparation and Property Characterization of Sm2EuSbO7/ZnBiSbO5 Heterojunction Photocatalyst for Photodegradation of Parathion Methyl under Visible Light Irradiation
Authors: Luan Jingfei , Hao Liang , Yao Ye , Wang Yichun , Yang Guangmin , Li Jun
Published: November 2023

An unprecedented photocatalyst, Sm2EuSbO7, was successfully fabricated in this paper, through a high-temperature solid-state calcination method, which represented its first ever synthesis. Additionally, using the solvothermal method, the Sm2EuSbO7/ZnBiSbO5 heterojunction photocatalyst (SZHP) was fabricated, marking its debut in this study. XRD analysis confirmed that both Sm2EuSbO7 and ZnBiSbO5 exhibited pyrochlore-type crystal structures with a cubic lattice, belonging to the Fd3m space group. The crystal cell parameter was determined to be 10.5682 Å or 10.2943 Å for Sm2EuSbO7 or ZnBiSbO5, respectively. The band gap width measured for Sm2EuSbO7 or ZnBiSbO5 was 2.73 eV or 2.61 eV, respectively. Under visible light irradiation for 150 min (VLTI-150 min), SZHP exhibited remarkable photocatalytic activity, achieving 100% removal of parathion methyl (PM) concentration and 99.45% removal of total organic carbon (TOC) concentration. The kinetic constant (k) for PM degradation and visible light illumination treatment was determined to be 0.0206 min−1, with a similar constant k of 0.0202 min−1 observed for TOC degradation. Remarkably, SZHP exhibited superior PM removal rates compared with Sm2EuSbO7, ZnBiSbO5, or N-doped TiO2 photocatalyst, accompanied by removal rates 1.09 times, 1.20 times, or 2.38 times higher, respectively. Furthermore, the study investigated the oxidizing capability of free radicals through the use of trapping agents. The results showed that hydroxyl radicals had the strongest oxidative capability, followed by superoxide anions and holes. These findings provide a solid scientific foundation for future research and development of efficient heterojunction compound catalysts.
Cytotoxic Natural Products Isolated from Cryptogramma crispa (L.) R. Br.
Authors: Diaz Andrea Estefania Carpinteyro , Herfindal Lars , Andersen Heidi Lie , Fossen Torgils
Published: November 2023

Parsley fern, Cryptogramma crispa, is a common fern in arctic–alpine regions, and even though this species has been known since ancient times and has been presumed to cause the poisoning of horses, its natural products have not previously been investigated. Here, we characterise 15 natural products isolated from the aerial parts of Cryptogramma crispa, including the previously undescribed compound 3-malonyl pteroside D. The structure determinations were based on several advanced 1D and 2D NMR spectroscopic techniques, Circular Dichroism spectroscopy and high-resolution mass spectrometry. The pteroside derivatives exhibited selective moderate cytotoxic activity against the acute myeloid leukaemia MOLM13 cell line and no cytotoxicity against the normal heart and kidney cell lines, suggesting that their potential anticancer effect should be further investigated.
Pharmacokinetics, Tissue Distribution and Excretion of Demethyleneberberine, a Metabolite of Berberine, in Rats and Mice
Authors: Li Jingqi , Zhang Qi , Chen Yutong , Lu Chengyu , Tong Yongbin
Published: November 2023

Demethyleneberberine is an active component extracted from the Chinese herbal drug Cortex Phellodendri. It is also a metabolite of berberine in animals and humans. However, the pharmacokinetics, tissue distribution and excretion of demethyleneberberine have not been reported. The present study aimed to investigate the pharmacokinetic parameters of demethyleneberberine by applying high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). After intragastric administration of demethyleneberberine in rats and mice, the pharmacokinetics, tissue distribution and excretion of demethyleneberberine were comparatively studied for the first time. The plasma concentration of demethyleneberberine reached its peak within 5 min after intragastric administration in both rats and mice. Furthermore, its bioavailability was comparable, ranging from 4.47% to 5.94%, higher than that of berberine. The total excretion of demethyleneberberine in the urine, feces and bile was 7.28~9.77%. These findings provide valuable insights into the pharmacological and clinical research on demethyleneberberine.
NMR “Finger Prints” of N-Heterocyclic Carbenes, DFT Analysis: Scopes and Limitations
Authors: Kondrashova Svetlana A. , Latypov Shamil K.
Published: November 2023

The scopes and limitations of theoretical methods for estimating various NMR metrics of NHCs are considered on a wide range of model NHCs and their derivatives, using a number of computational approximations. On the whole, the most reliable, from the point of view of predictability and insusceptibility to additional effects, are 31P/13C NMR shifts of NHC–phosphinidene adducts and 13C CSs of carbenes themselves. The method based on the analysis of 77Se CS NHC–selenoureas has some limitations since the observed NMR parameters can also be modulated by exchange effects due to their formation with non-classical hydrogen bonds. As for HEP, since the delicate balance of electron distribution between Pd and two carbon centers can nonlinearly affect relativistic spin–orbit effects, the accuracy of the estimation of this metric may still be limited. 13C CSs of NHC–azolium salts do not seem to be reliable, since the observed values are strongly influenced by the effects of the exchange between different forms with counterions, which are difficult to estimate correctly.
Toxicity and Repellency Efficacy of Benzyl Alcohol and Benzyl Benzoate as Eco-Friendly Choices to Control the Red Flour Beetle Tribolium castaneum (Herbst. 1797)
Authors: Aboelhadid Shawky M. , Ibrahium Samar M. , Abdel-Tawab Heba , Hassan Ahmed O. , Al-Quraishy Saleh , Saleh Fatma El-zahraa R. , Abdel-Baki Abdel-Azeem S.
Published: November 2023

Tribolium castaneum is a damaging pest of stored grains, causing significant losses and secreting lethal quinones, which render the grains unfit for human consumption. Chemical insecticides are the most commonly used approach for control; however, they create insecticide resistance and affect the health of humans, animals, and the environment. As a result, it is critical to find an environmentally friendly pest-management strategy. In this study, two naturally occurring chemicals, benzyl alcohol (BA) and benzoyl benzoate (BB), were investigated for insecticidal activity against T. castaneum using different assays (impregnated-paper, contact toxicity, fumigant, and repellency assays). The results showed that BA had a significant insecticidal effect, with the LC50 achieved at a lower concentration in the direct-contact toxicity test (1.77%) than in the impregnated-paper assay (2.63%). BB showed significant effects in the direct-contact toxicity test, with an LC50 of 3.114%, and a lower toxicity in the impregnated-paper assay, with an LC50 of 11.75%. Furthermore, BA exhibited significant fumigant toxicity against T. castaneum, with an LC50 of 6.72 µL/L, whereas BB exhibited modest fumigant toxicity, with an LC50 of 464 µL/L. Additionally, at different concentrations (0.18, 0.09, 0.045, and 0.0225 µL/cm2), BA and BB both showed a notable and potent repelling effect. BA and BB significantly inhibited acetylcholinesterase, reduced glutathione (GSH), and increased malondialdehyde (MDA) in treated T. castaneum. This is the first report of BA insecticidal activity against the red flour beetle. Also, the outcomes of various assays demonstrated that the application of BA induces a potent bio-insecticidal effect. BA may be a promising eco-friendly alternative to control T. castaneum due to its safety and authorization by the EFSA (European Food Safety Authority).
A Novel Spectrophotometric Method for Determination of Percarbonate by Using N, N-Diethyl-P-Phenylenediamine as an Indicator and Its Application in Activated Percarbonate Degradation of Ibuprofen
Authors: Li Jinying , Chen Aoxue , Meng Qingling , Xue Honghai , Yuan Baoling
Published: November 2023

Sodium percarbonate (SPC) concentration can be determined spectrophotometrically by using N, N-diethyl-p-phenylenediamine (DPD) as an indicator for the first time. The ultraviolet–visible spectrophotometry absorbance of DPD•+ measured at 551 nm was used to indicate SPC concentration. The method had good linearity (R2 = 0.9995) under the optimized experimental conditions (pH value = 3.50, DPD = 4 mM, Fe2+ = 0.5 mM, and t = 4 min) when the concentration of SPC was in the range of 0–50 μM. The blank spiked recovery of SPC was 95–105%. The detection limit and quantitative limit were 0.7–1.0 μM and 2.5–3.3 μM, respectively. The absorbance values of DPD•+ remained stable within 4–20 min. The method was tolerant to natural water matrix and low concentration of hydroxylamine (<0.8 mM). The reaction stoichiometric efficiency of SPC-based advanced oxidation processes in the degradation of ibuprofen was assessed by the utilization rate of SPC. The DPD and the wastewater from the reaction were non-toxic to Escherichia coli. Therefore, the novel Fe2+/SPC-DPD spectrophotometry proposed in this work can be used for accurate and safe measurement of SPC in water.
Sonosensitive Cavitation Nuclei—A Customisable Platform Technology for Enhanced Therapeutic Delivery
Authors: Lyons Brian , Balkaran Joel P. R. , Dunn-Lawless Darcy , Lucian Veronica , Keller Sara B. , O’Reilly Colm S. , Hu Luna , Rubasingham Jeffrey , Nair Malavika , Carlisle Robert , Stride Eleanor , Gray Michael , Coussios Constantin
Published: November 2023

Ultrasound-mediated cavitation shows great promise for improving targeted drug delivery across a range of clinical applications. Cavitation nuclei—sound-sensitive constructs that enhance cavitation activity at lower pressures—have become a powerful adjuvant to ultrasound-based treatments, and more recently emerged as a drug delivery vehicle in their own right. The unique combination of physical, biological, and chemical effects that occur around these structures, as well as their varied compositions and morphologies, make cavitation nuclei an attractive platform for creating delivery systems tuned to particular therapeutics. In this review, we describe the structure and function of cavitation nuclei, approaches to their functionalization and customization, various clinical applications, progress toward real-world translation, and future directions for the field.
Correction: Youssef et al. Phytochemical Analysis and Profiling of Antitumor Compounds of Leaves and Stems of Calystegia silvatica (Kit.) Griseb. Molecules 2023, 28, 630
Authors: Youssef Ahmed M. M. , Maaty Doaa A. M. , Al-Saraireh Yousef M.
Published: November 2023

There were errors in the original publication [...]
Cobalt Ferrite Synthesized Using a Biogenic Sol–Gel Method for Biomedical Applications
Authors: Gomes Patrícia , Costa Bárbara , Carvalho João P. F. , Soares Paula I. P. , Vieira Tânia , Henriques Célia , Valente Manuel Almeida , Teixeira Sílvia Soreto
Published: November 2023

Cancer is one of the leading causes of death worldwide. Conventional treatments such as surgery, chemotherapy, and radiotherapy have limitations and severe side effects. Magnetic hyperthermia (MH) is an alternative method that can be used alone or in conjunction with chemotherapy or radiotherapy to treat cancer. Cobalt ferrite particles were synthesized using an innovative biogenic sol–gel method with powder of coconut water (PCW). The obtained powders were subjected to heat treatments between 500 °C and 1100 °C. Subsequently, they were characterized by thermal, structural, magnetic, and cytotoxic analyses to assess their suitability for MH applications. Through X-ray diffraction and Raman spectroscopy, it was possible to confirm the presence of the pure phase of CoFe2O4 in the sample treated at 1100 °C, exhibiting a saturation magnetization of 84 emu/g at 300 K and an average grain size of 542 nm. Furthermore, the sample treated at 1100 °C showed a specific absorption rate (SAR) of 3.91 W/g, and at concentrations equal to or below 5 mg/mL, is non-cytotoxic, being the most suitable for biomedical applications.
Tailoring a N-Doped Nanoporous Carbon Host for a Stable Lithium Metal Anode
Authors: Lee In-Hwan , Jin Yongsheng , Jang Hyeon-Sik , Whang Dongmok
Published: November 2023

Li metal is a promising anode candidate due to its high theoretical capacity and low electrochemical potential. However, dendrite formation and the resulting dead Li cause continuous Li consumption, which hinders its practical application. In this study, we realized N-doped nanoporous carbon for a stable Li metal host composed only of lightweight elements C and N through the simple calcination of a nitrogen-containing metal–organic framework (MOF). During the calcination process, we effectively controlled the amount of lithophilic N and the electrical conductivity of the N-doped porous carbons to optimize their performance as Li metal hosts. As a result, the N-doped porous carbon exhibited excellent electrochemical performances, including 95.8% coulombic efficiency and 91% capacity retention after 150 cycles in a full cell with an LFP cathode. The N-doped nanoporous carbon developed in this study can realize a stable Li metal host without adding lithium ion metals and metal oxides, etc., which is expected to provide an efficient approach for reliable Li metal anodes in secondary battery applications.
Trichomonas vaginalis: Monolayer and Cluster Formation—Ultrastructural Aspects Using High-Resolution Scanning Electron Microscopy
Authors: Ortiz Sharmila Fiama das Neves , Verdan Raphael , Fortes Fabio da Silva de Azevedo , Benchimol Marlene
Published: November 2023

Trichomonas vaginalis is an extracellular protozoan parasite that causes human trichomoniasis, a sexually transmitted infection (STI) that affects approximately 270 million people worldwide. The phenomenon of T. vaginalis adhesion to inert substrates has been described in several reports. Still, very few studies on cluster formation have been conducted, and more detailed analyses of the contact regions between the parasites’ membranes in these aggregate formations have not been carried out. The present study aims to show that T. vaginalis forms a tight monolayer, similar to an epithelium, with parasites firmly adhered to the culture flask bottom by interdigitations and in the absence of host cells. In addition, we analyzed and compared the formation of the clusters, focusing on parasite aggregates that float in the culture flasks. We employed various imaging techniques, including high-resolution scanning electron microscopy, transmission electron microscopy, cytochemistry, TEM tomography, and dye injection. We analyzed whether the monolayer behaves as an epithelium, analyzing cell junctions, cell communication, and ultrastructural aspects, and concluded that monolayer formation differs from cluster formation in many aspects. The monolayers form strong adhesion, whereas the clusters have fragile attachments. We did not find fusion or the passage of molecules between neighbor-attached cells; there is no need for different strains to form filopodia, cytonemes, and extracellular vesicles during cluster and monolayer formation.
Antiviral Effects of Secondary Metabolites from Jatropha podagrica Leaves against the Pseudotyped Virus of SARS-CoV-2 Omicron
Authors: Jang Yoon Seo , Lee Da Eun , Ju Dong U , Jeong Se Yun , Ko Yoon-Joo , Pang Changhyun , Kang Ki Sung , Gwon Hui-Jeong , Yoo Hee Min , Kim Ki Hyun
Published: November 2023

Jatropha podagrica holds a longstanding place in traditional herbal medicine, primarily utilized for addressing skin infections, acting as antipyretics, diuretics, and purgatives. In this study, our primary objective was to investigate the secondary metabolites present in J. podagrica leaves, with the aim of pinpointing natural compounds exhibiting potential antiviral activities. Five secondary metabolites (1–5), including an auronol glycoside (1), two coumarins (2 and 3), a chromane (4) and a gallotannin (5), were isolated from J. podagrica leaves. Compound 1 presented as an amalgamation of unseparated mixtures, yet its intricate composition was adroitly unraveled through the strategic deployment of a chiral HPLC column. This tactic yielded the isolation of epimers (+)-1 and (−)-1, ascertained as unreported auronol glycosides. The structures of these novel compounds, (+)-1 and (−)-1, were elucidated to be (2S)-hovetrichoside C [(+)-1] and (2R)-hovetrichoside C [(−)-1] through NMR data and HR-ESIMS analyses, enzymatic hydrolysis, and comparison of optical rotation values. Cytotoxicity and antiviral effects were assessed for the isolated compounds ((+)-1, (−)-1 and 2–5), along with compound 1a (the aglycone of 1), in the A549 human alveolar basal epithelial cell line. Each compound demonstrated a cell viability of approximately 80% or higher, confirming their non-toxic nature. In the group of compounds, compounds 3–5 demonstrated antiviral effects based on RT-qPCR results, with individual enhancements ranging from approximately 28 to 38%. Remarkably, compound 4 exhibited the most substantial antiviral effect. Utilization of compound 4 to assess immune boosting and anti-inflammatory effects revealed increased levels of STING, RIG-I, NLRP3, and IL-10 along with a decrease in TNF-α and IL-6. Therefore, these findings underscore the potential of these active compounds 3–5 not only as therapeutic agents for SARS-CoV-2 but also as new contenders for upcoming pandemics.
Validation of Novel Reference Genes in Different Rice Plant Tissues through Mining RNA-Seq Datasets
Authors: Liu Xin , Gao Yingbo , Zhao Xinyi , Zhang Xiaoxiang , Ben Linli , Li Zongliang , Dong Guichun , Zhou Juan , Huang Jianye , Yao Youli
Published: November 2023

Reverse transcription quantitative real-time PCR (RT-qPCR) is arguably the most prevalent and accurate quantitative gene expression analysis. However, selection of reliable reference genes for RT-qPCR in rice (Oryza sativa) is still limited, especially for a specific tissue type or growth condition. In this study, we took the advantage of our RNA-seq datasets encompassing data from five rice varieties with diverse treatment conditions, identified 12 novel candidate reference genes, and conducted rigorous evaluations of their suitability across typical rice tissues. Comprehensive analysis of the leaves, shoots, and roots of two rice seedlings subjected to salt (30 mmol/L NaCl) and drought (air-dry) stresses have revealed that OsMED7, OsACT1, and OsOS-9 were the robust reference genes for leaf samples, while OsACT1, OsZOS3-23, and OsGDCP were recommended for shoots and OsMED7, OsOS-9, and OsGDCP were the most reliable reference genes for roots. Comparison results produced by different sets of reference genes revealed that all these newly recommended reference genes displayed less variation than previous commonly used references genes under the experiment conditions. Thus, selecting appropriate reference genes from RNA-seq datasets leads to identification of reference genes suitable for respective rice tissues under drought and salt stress. The findings offer valuable insights for refining the screening of candidate reference genes under diverse conditions through the RNA-seq database. This refinement serves to improve the accuracy of gene expression in rice under similar conditions.
The Development of Floral Scent Research: A Comprehensive Bibliometric Analysis (1987–2022)
Authors: Peng Qin , Zhang Yangyang , Fan Junjun , Shrestha Anil , Zhang Wangxiang , Wang Guangyu
Published: November 2023

Floral scent (FS) plays a pivotal role in maintaining ecological equilibrium within plant populations and ecosystems while also bearing significance for human well-being. Despite the growing interest in FS research, there exists a dearth of comprehensive analyses on research trends, contemporary topics, and their broader implications. In this study, we employ bibliometric techniques using data from the Web of Science Core Collection spanning 1987–2022 to offer a quantitative overview of the scientific literature surrounding FS by examining the annual publication outputs, popular research areas, temporal trends in keywords, geographic distribution of relevant studies, institutions, co-organizations, as well as relevant authors. Our findings reveal a marked upsurge in FS publications, notably within the domains of Food Science Technology, Plant Sciences, Chemistry, Agriculture, Biochemistry, and Molecular Biology. The research landscape in FS primarily encompasses evolutionary dynamics, volatile compound analyses, biosynthesis mechanisms, and essential oil properties. These research trends signify a transition from micro-level exploration, focusing on individual pollination ecological functions of FS, to a macro-perspective that emphasizes FS’s overarching impact on species diversity and ecosystem stability. This shift extends from the investigation of singular sensory attributes of FS to a holistic evaluation of their role in food production, quality, and yield enhancement. It encompasses a move away from mere FS extraction towards the examination of antioxidant potential within phenolic compounds and other industrial applications. Thus, improving research methodologies, strengthening interdisciplinary collaboration on an international scale, and delving deeper into the multifaceted ecological functions of floral diversity and their societal implications will be paramount.
Genome-Wide Development of Polymorphic SNP Markers and Evaluation of Genetic Diversity of Litchi (Litchi chinensis Sonn.)
Authors: Liu Wei , Xiao Zhidan , Jiang Nonghui , Fan Chao , Xiang Xu
Published: November 2023

Litchi (Litchi chinensis Sonn.) is a highly valuable fruit crop that is widely grown in tropical and subtropical areas of the world. Studying its genetic diversity and population structure is critical for effective conservation and breeding programs. In this study, we developed 150 single-nucleotide polymorphism (SNP) markers that were evenly spaced across litchi genome and applied them to the evaluation of the genetic diversity of 84 litchi accessions, including old cultivars, modern cultivars, hybrids from known parents and wild accessions. Ninety-one SNP markers, showing high levels of polymorphism and high genotyping success rates, were used for further analysis. The newly developed SNP markers captured a relatively higher level of genetic diversity (He = 0.364) in litchi cultivars and could be successfully applied for the identification of synonymous cultivars and hybrids with close genetic backgrounds. Cluster analysis grouped all genotypes into three clusters that showed perfect association with their fruit maturation period, among which wild accessions clustered with their corresponding domesticated cultivars, and hybrids from different parent combinations showed different inheritance tendencies. Our study not only provided a set of efficient SNP markers for future genetic research, but also laid an important foundation for the conservation and genetic breeding of litchi.
The Indigenization Policy of Propaganda Fide: Its Effectiveness and Limitations in China (1622–1742)
Authors: Zhang Rui
Published: November 2023

The papal Sacred Congregation de Propaganda Fide, founded in 1622, marks a milestone in the history of Christianity by promoting a new way of organizing “apostolic missionaries”, which represented a major shift from colonial missions to purely ecclesiastical missions. The emphasis on the indigenization of clergy was a central element in its vision right from the founding documents. Propaganda Fide, bypassing the old patronage system, sought to extend the indigenization policy worldwide, though it faced difficulties and obstacles from religious orders and secular powers. This article introduces the history of the development of Propaganda Fide’s indigenization policy and analyzes the early attempts to apply the policy in China, evaluating both its effectiveness and limitations across the first 120 years.
Community Perceptions of the Importance of Heritage Protection Relative to Other Local Government Council Operations
Authors: Spennemann Dirk H. R.
Published: November 2023

Cultural heritage management at the local government level relies on community participation, mainly interested stakeholders, in the identification, nomination and, in some jurisdictions, the co-evaluation of heritage assets. These are then “listed,” i.e., included in planning schemes and other development controls. Such inclusion in planning schemes is predicated on the assumption that the local community values its heritage, appreciates its protection and supports local council investment and actions in the matter. This assumption is treated as axiomatic but only very rarely formally tested. Drawing on a community heritage survey in Albury, a regional service center in southern New South Wales (Australia), this paper discusses the perceptions held by the community on the relative importance of heritage protection when compared with the other services offered by council. The findings show that the community ranked cultural and natural heritage places higher than cultural institutions (museums, libraries and theatres). The findings also showed that the community valued cultural and natural heritage more than traditional engineering services, such as roads/footpaths, rubbish removal and even sporting facilities. The survey highlighted intergenerational differences, with cultural heritage places and cultural institutions ranking high only among Generation X and the generations prior (Builders and Baby Boomers). This has clear implications for the present provisioning of heritage services and community education. The paper concludes with an exploration of the long-term implications of the observed intergenerational differences for local government authorities and community development in general.
Preferences for Alternative Fuel Trucks among International Transport Companies
Authors: Jahaniaghdam Tannaz , Mamdoohi Amir Reza , Kheyrabadi Salman Aghidi , Mehryar Mehdi , Ciari Francesco
Published: November 2023

Fossil-fuel consumption in land freight is over 19%. Alternative fuel trucks (AFTs) help decrease greenhouse gas emissions. However, AFT preferences in international land transit have received little attention due to passing through various countries with different financial and regulation plans. This variety affects AFTs’ market share. This study analyzes factors influencing AFT preferences in international land transit. A questionnaire (designed in four sections) was distributed among international transport companies in Iran and Europe. A principal component analysis helped extract principal components composed of cognitive, environmental, policy, practical, and economic variables. The multinomial logit models include 26 meaningful variables. The marginal effect analysis shows that the service quality of the manufacturer, importance of greenhouse gas mitigation, and social responsibility do not significantly elevate AFT preferences. In addition, cargo type influences AFT choice. The results of this study help to identify the barriers affecting AFTs’ market share, which can positively impact air pollution.
Experiencia del empleo de medios visuales como recursos educativos en educación virtual
Authors: Castro Blanco Yudi , Antúnez Sánchez Armando Guillermo
Published: November 2023

El aula virtual como escenario para impartir clases a distancia, obliga al docente a buscar propuestas educativas que mejoren la comprensión de los contenidos. Alternativas muy sugerentes pueden ser las que se apoyan de imágenes al ser más simples de entender que un texto. En tal sentido, en la presente investigación se muestra la experiencia del empleo de medios visuales como recursos educativos en el curso de Redacción Científica en la Universidad de Granma, Cuba. Este programa se impartió de marzo a abril del año 2020, período que existía aislamiento social provocado por la Covid – 19, lo cual constituyó un reto aún mayor. Como resultado, se presentó la materia mediante un aula virtual iconográfica, videos tutoriales, mapas conceptuales y objetos de aprendizaje. Se concluye que, como efecto de la utilización de estas propuestas, los educandos lograron niveles altos de aprendizaje y adquirieron las habilidades concebidas en el curso.
Estimulación de habilidades comunicativas en niños de Educación Inicial
Authors: Peñafiel Villarreal Ruth Esther , Mejía Atiencia Melissa Iliana , Salazar Murillo Odalis Belén
Published: November 2023

La investigación se enfoca en la estimulación de habilidades comunicativas en niños del Inicial I con lo cual se le brinda al docente conocimiento sobre las estrategias más adecuadas para propiciar el desarrollo integral del infante. El objetivo de la investigación fue analizar el nivel de desarrollo de las Habilidades Comunicativas en niños de 3 a 4 años de la Unidad Educativa ¨Presidente Tamayo¨ para lo cual se realizó un trabajo de campo bajo un enfoque cualitativo y un alcance descriptivo. La población de estudio estuvo compuesta por 29 niños de Educación Inicial I, representantes, personal docente y la directora. La muestra seleccionada fue de10 niños, sus representantes, una profesora y la directora a quienes se les aplicó una entrevista y la observación sistematizada. En los resultados se evidenciaron las dificultades que presentan los infantes en el desarrollo de las habilidades comunicativas y se concluye con la importancia de fomentar actividades que contribuyan al desarrollo de las habilidades comunicativas durante el proceso de aprendizaje.
Морфология стромального и паренхиматозного компонентов печени при артериальной гипертензии
Authors: Железнякова О.Е. , Слесарева Е.В. , Кузнецова Т.И.
Published: November 2023

Патология сердечно-сосудистой системы, а в частности развитие артериальной гипертензии и как следствие хронической сердечной недостаточности остается растущей глобальной эпидемией. Хроническая сердечно-сосудистая недостаточность сопровождается развитием хронического общего венозного полнокровия, которое приводит к тяжелым, нередко необратимым изменениям органов и тканей. Печень, один из основных органов, страдающих от развития хронической сердечной недостаточности, вовлечённый в процессы регуляции сосудистого тонуса. В связи с этим является актуальным изучение морфометрических параметров стромально-паренхиматозных компонентов печени в условиях артериальной гипертензии. Длительное течение артериальной гипертензии вызывает изменения преимущественно в синусоидных капиллярах и пространствах Диссе, приводя к их значительной дилатации. Данные структурные изменения сказываются на функциональной активности гепатоцитов и клеток, образующих стенку капилляров. Отсутствие значимого роста площади стромы печени даже в группе больных, страдающих артериальной гипертензией более 15 лет, свидетельствует о компенсаторных возможностях сердечно-сосудистой системы в отношении развития венозного застоя.

Ключевые слова: артериальная гипертензия, хроническая сердечная недостаточность, печень, морфология.
Эффективность комплексов упражнений фитбол-гимнастики для коррекции и профилактики нарушения осанки у девочек в возрасте 12-13 лет с лёгкой степенью умственной отсталости
Authors: Ланская О.В.
Published: November 2023

В работе представлены сведения об эффективности комплексов упражнений фитбол-гимнастики для девочек 12-13 лет с лёгкой степенью умственной отсталости, имеющих нарушение осанки в сагиттальной плоскости. Об этом свидетельствует положительная динамика показателей функционального состояния опорно-двигательного аппарата (подвижности поясничного отдела позвоночника, силовой выносливости мышц-разгибателей спины и мышц брюшного пресса) и эмоционального статуса данного контингента лиц к окончанию эксперимента.

Ключевые слова: умственная отсталость, девочки, нарушение осанки, фитбол-гимнастика.
Влияние уровня коронарного кальция на когнитивные функции у пациентов с артериальной гипертонией и бронхиальной астмой
Authors: Мубинова Л.А. , Разин В.А.
Published: November 2023

В материалах представлены результаты исследования по влиянию уровня коронарного кальция на когнитивные функции пациентов, имеющих сопутствующие патологии - артериальную гипертонию и бронхиальную астму. Выявлено, что группа пациентов с АГ в сочетании с БА имеет легкую степень нарушения когнитивных функций согласно результатам, полученным по MoCa тесту.

Ключевые слова: Коморбидность, артериальная гипертензия, бронхиальная астма, кальциевый индекс, когнитивный дефицит, когнитивные функции.
Динамика функционального состояния у работников дрейфующей полярной станции «Северный полюс 41»
Authors: Панкова Н.Б. , Буйнов Р.П. , Фильчук К.В. , Черепов А.Б. , Карганов М.Ю.
Published: November 2023

Прослежены показатели функционального состояния 14 мужчин (средний возраст 46,0±3,6 лет), работавших на СП-41, с 3-5 дней после начала экспедиции, до 6 месяцев. Обнаружена стабильность показателей физической работоспособности, сердечной производительности, общих показателей сердечного ритма и его вариабельности, показателей систолического артериального давления и его вариабельности. Динамика оказалась характерна только для показателей диастолического артериального давления и пульсового давления. Информативным также оказался индекс функциональных изменений (ИФИ). Общим трендом было наличие выраженных реакций (повышенные значения) на первой точке тестирования, нормализация показателей через месяц, и постепенное возрастание (в пределах нормальных величин) в последующие сроки.

Ключевые слова: функциональное состояние, вариабельность сердечного ритма, вариабельность артериального давления, адаптация, Север.
Влияние экспрессии андрогеновых рецепторов на клинико-морфологические особенности и выживаемость пациентов с трижды негативным раком молочной железы
Authors: Панченко И.С. , Родионов В.В. , Панченко С.В. , Шарафутдинов М.Г.
Published: November 2023

Цель работы - определить влияние экспрессии андрогеновых рецепторов на клиническое течение и прогноз у пациенток с трижды негативным раком молочной железы.

Проведен анализ клинико-морфологических и прогностических параметров у 253 пациенток с инвазивным трижды негативным раком молочной железы.

Было продемонстрировано, что экспрессия андрогенных рецепторов при трижды негативном раке молочной железы статистически значимо ассоциируется с возрастом, местно-распространенной формой заболевания, мультифокальным характером роста, инвазивным дольковым и особым гистологическим формами опухолей, низкой степенью злокачественности, низким уровнем Ki67 и не ассоциируется с общей и безрецидивной выживаемостью.

Установлено, что экспрессия андрогеновых рецепторов при трижды негативном раке молочной железы ассоциируется с определенными клинико-морфологическим параметрами опухоли, но не влияет на прогноз.

Ключевые слова: рак молочной железы, трижды негативный рак молочной железы (ТНРМЖ), андрогеновые рецепторы (АР), общая выживаемость, безрецидивная выживаемость.
Параметры регенерации тканей после герниопротезирования
Authors: Титова Е.В.
Published: November 2023

Исследование особенностей морфогенеза в зоне имплантации ксеноперикардиальной пластины включало оценку морфологических особенностей интеграции и динамику матриксной металлопротеиназы-9. Отмечено активное формирование соединительной ткани вокруг биологического протеза, увеличение концентрации матриксной металлопротеиназы-9, обладающей профиброгенным эффектом.

Ключевые слова: герниопластика, регенерация, ксеноперикард.
Predictors of Mothers’ Care Seeking Behavior for Common Childhood Illnesses: Findings From the Afghanistan Health Survey 2015
Authors: Tawfiq Essa , Saeed Khwaja Mir Islam , Shah Alawi Sayed Ali , Jawaid Jammalluddin , Hashimi Syed Nasir
Published: November 2023

Background: Mothers’ care seeking behavior for childhood illness is a key factor of utilizing healthcare for children. We examined predictors of mothers’ care seeking for common childhood illnesses. Methods: This was a cross-sectional study, using data from the Afghanistan Health Survey (AHS) 2015. Data were used from women who sought healthcare for their unwell children. The women were asked whether their children were sick with fever, cough, faster breathing, or diarrhea in the past 2 weeks. The outcome variable was defined as whether the mother sought healthcare for her unwell child from a public clinic, a private clinic, or from a pharmacy store. The Andersen’s healthcare seeking behavior model was used and multinomial regression analysis applied. Results: There were 4979 women, aged 15-49 years, whose under-5 children were sick in the past 2 weeks. Thirty-nine percent of women sought healthcare for their children from a health provider. Mother’s age, child’s age, child’s sex, socioeconomic status, mothers’ perceived severity of childhood illness, and number of under-5 children were predictors of mothers’ care seeking behavior. The likelihood of healthcare seeking was lower for older children (Adjusted odds ratio [OR] [95% CI]: 0.51 [0.37-0.70] from public clinics; 0.33 [0.23-0.47] from private clinics; 0.36 [0.22-0.61] from pharmacy stores), and for girls (Adjusted OR [95% CI]: 0.74 [0.59-0.93] from private clinics). The likelihood of healthcare seeking was greater for children whose mothers knew symptoms of childhood illness (Adjusted OR [95% CI]: 2.97 [1.44-6.16] from public clinics; 7.20 [3.04-17.04] from pharmacy stores). The likelihood of healthcare seeking for children was greater in older mothers (Adjusted OR [95% CI]: 1.54 [1.11-2.12]). It was less likely for the mothers who have more children to seek healthcare for their children (Adjusted OR [95% CI]: 0.53 [0.43-0.65] from public clinics; 0.61 [0.48- 0.79] from private clinics; 0.51 [0.37-0.69] from pharmacy stores). Conclusion: Health policy-makers may opt to use our findings, particularly mothers’ knowledge (perceived severity) of symptoms of childhood illness to develop interventions to enhance timely assessment and effective treatment of common preventable childhood illnesses.
Patients’ and Care Professionals’ Evaluation of the Effect of a Hospital Group on Integrated Care in Chinese Urban Health Systems: A Propensity Score Matching and Difference-in-differences Regression Approach
Authors: Wang Xin , Zheng Caiyun , Wang Yao , Birch Stephen , Huang Yixiang , Valentijn Pim
Published: November 2023

Background: A hospital group is an organizational integration strategy that has recently been widely implemented in Chinese urban health systems to promote integrated care. This study aims to evaluate the effect of hospital group on integrated care from the perspectives of both patients and care professionals. Methods: Two cross-sectional surveys were conducted in Shenzhen city of China, in June 2018 and July 2021. All thirty Community Health Stations (CHSs) in the hospital group were included in the intervention group, with 30 CHSs in the same district selected as the control group by simple random sampling. All care professionals within both the intervention and the control groups were invited to participate in the surveys. Twelve CHSs were selected from 30 CHSs in the intervention and the control groups by simple random sampling, and 20 patients with type 2 diabetes mellitus (T2DM) were selected from each of these selected CHSs to participate in the survey by systematic sampling. The Rainbow Model of Integrated Care-Measurement Tool (Chinese version) was used to assess integrated care. Propensity score matching and difference-in-differences regression (PSM-DID) were used to evaluate the effect of the hospital group on integrated care. Results: After matching, 528 patients and 1896 care professionals were included in the DID analysis. Results from care professionals indicated that the hospital group significantly increased technical competence of the health system by 0.771 points, and cultural competence by 1.423 points. Results from patients indicated that the hospital group significantly decreased organizational integration of the health system by 0.649 points. Conclusion: The results suggests that the effect of the hospital group on integrated care over and above routine strategies for integrated care is limited. Therefore, it is necessary to pay attention to implementing professional, clinical and other integration strategies beyond establishing hospital groups, in urban Chinese health systems.
Pengembangan Game 2D Pembelajaran Tentang Covid-19 Sebagai Media Pembelajaran Untuk Masyarakat Berbasis Android
Authors: Dewi Meilany , Trisnadoli Anggy , Surya Ibnu
Published: November 2023

Covid-19 adalah akronim untuk kata-kata bahasa Inggris â€œCorona Virus Disease â€“ 2019â€. Tingginya pertumbuhan pengguna game mobile masyarakat di Indonesia yang cukup besar dengan total jumlah pemain game mobile di Indonesia mencapai 100 juta pada tahun 2020. Dengan tingginya pertumbuhan pengguna game mobile masyarakat di Indonesia alternatif media pembelajaan dalam bentuk game dapat diterapkan untuk menghimbau masyarakat tentang bahaya, cara penularan dan akibat dari covid.  Game edukasi ini dibangun sebagai media pembelajaran bagi masyarakat untuk dapat memahami tentang covid-19, memahami tentang covid-19, akibat yang ditimbulkan, cara penularan serta cara pencegahanya. Dalam penelitian ini dilakukan survey kepada 30 responden dengan cukup beragam dari berbagai kalangan siswa dan mahasiswa, pengusaha, karyawan, ibu rumah tangga dan sebagainya. Hasil penelitian menunjukan bahwa dengan adanya game ini, dapat menjadi alternatif menambah pengetahuan dan pemahaman tentang COVID-19 serta media pembelajaran berbasis game bagi masyarakat. Hiburan yang diberikan oleh game pembelajaran berbasis mobile dapat menjadi sarana pembelajaran yang menarik bagi masyarakat.
Implementasi OCR dengan Metode Autoencoder pada Aplikasi Bukutamu berbasis WEB
Authors: Rizaldi Muhamad Aldi , Kaburuan Emil R.
Published: November 2023

Bukutamu adalah alat untuk mencatat identitas pengunjung yang datang kesuatu tempat atau acara seperti acara pernikahan, perayaan ulang tahun, pesta dll. Tidak hanya sekedar mencatat, bukutamu juga berfungsi sebagai bukti dan jejak untuk menghindari terjadinya sesuatu yang tidak diinginkan. Sehingga tidak heran dibeberapat tempat diharuskan untuk menyerahkan kartu identitas seperti KTP saat mengisi bukutamu agar diperbolehkan masuk ketempat tersebut. KTP sendiri merupakan kartu identitas yang berisi data nama, tempat, tanggal lahir dll. Data yang tercantum dalam KTP tersebut dapat dimanfaatkan dalam proses pengisian bukutamu sehingga petugas hanya perlu mengambil gambar KTP tersebut dan data pengunjung akan terisi secara otomatis dengan bantuan optical character recognition(OCR). Untuk mendapatkan hasil OCR yang baik diperlukan gambar dengan tulisan yang jelas, posisinya yang tidak miring dan ukurannya yang tidak terlalu kecil.  Oleh karna itu diperlukan berbagai tahap preprocessing sebelum melakukan proses OCR, salah satunya dengan menerapkan denoise menggunakan metode Autoencoder yang berhasil membuat gambar lebih bersih dan hasil OCR menjadi lebih akurat.
Perbandingan Kinerja Ingress Controller Pada Kubernetes Menggunakan Traefik Dan Nginx
Authors: Ramadhani Wisnu , Fadhly Ridha Muhammad Arif
Published: November 2023

Pada perkembangan zaman saat ini banyak cara untuk mengekspos sebuah service pada server kubernetes agar dapat digunakan oleh client salah satunya NodePort dan LoadBalancer, tetapi mengekspos menggunakan NodePort dan Loadbalancer client harus tau semua IP Node dan semua IP LoadBalancer yang terespos ke public. Oleh karena itu, ingress hadir untuk memudahkan client mengakses service dengan hanya menggunakan domain ingress. Proyek akhir ini membandingkan latency, throughput, tingkat kecepatan server menyelesaikan request, pemakaian CPU dan pemakaian memori pada saat membuka halaman web, antara kube ingress traefik, kube ingress nginx dan kube tanpa ingress. Diperoleh hasil pengujian latency tertinggi yaitu 356103.5ms oleh Server Kubernetes cluster tanpa ingress (Loadbalancer) dan latency terendah yaitu 5954.1ms oleh Server Kubernetes cluster ingress traefik. Throughput tertinggi yaitu 3268.8 second oleh Server Kubernetes cluster ingress nginx dan Throughput terendah yaitu 11.1 second oleh Server Kubernetes cluster ingress traefik. Dalam pengujian menggunakan Apache Benchmark Server Kubernetes cluster ingress traefik dapat menyelesaikan 100, 300 dan 500 request client lebih dahulu dibandingkan kedua server lainnya. Dalam keadaan busy, pemakaian CPU tertinggi adalah server Kubernetes cluster ingress nginx yaitu 99%, pemakaian memory tertinggi adalah server Kubernetes cluster ingress traefik yaitu 46%.
Aplikasi Penentuan Dosis Kebutuhan Pupuk Nitrogen Berdasarkan BWD Pada Tanaman Padi
Authors: Triyani Yuli , Djojo Kusuma Andika
Published: November 2023

Nitrogen adalah salah satu unsur hara yang sangat dibutuhkan untuk pertumbuhan vegetatif padi, tetapi pemberian pupuk yang berlebihan dapat merusak tanaman. Pemberian pupuk nitrogen secara seimbang pada tanaman padi merupakan solusi untuk dapat memperbaiki pertumbuhan tanaman padi agar produktivitasnya menjadi lebih optimal. Untuk mendapatkan takaran pupuk yang sesuai petani harus menggunakan tabel BWD, namun BWD ini sulit didapatkan, harganya terbilang mahal, dan penggunaannya dilakukan secara manual dengan cara membandingkan warna daun padi dengan warna setiap level pada tabel BWD. Presepsi berbeda-beda diantara setiap penggunaannya sering terjadi. Oleh karena itu dirancang aplikasi penentuan kebutuhan pupuk nitrogen berdasarkan BWD pada tanaman padi. Sistem ini terdiri dari tahap pre-processing, ekstraksi ciri dan klasifikasi. Tahap pre-processing merupakan tahap memperbaiki kualitas citra, sedangkan tahap ekstraksi ciri menggunakan metode histogram of s-RGB untuk mendapatkan nilai Mean dan Modus dari intensitas warna daun padi. Sistem ini mengklasifikasi berdasarkan ciri-ciri yang telah diekstrasi menjadi kelas 3 kelas yaitu: 2-3, 3-4, dan 4-5 berdasarkan level BWD. Kemudian sistem akan menghitung dosis pupuk nitrogen yang dibutuhkan berdasarkan data input GKG dan luas lahan. Tahap klasifikasi menggunakan metode K-NN. Berdasarkan hasil training menggunakan 210 citra dan pengujian terhadap 90 citra daun padi diperoleh hasil terbaik menggunakan k-NN 3 tetangga dengan akurasi 95,5%, AUC 0.98 dan waktu training 0,8 detik. Sehingga dapat disimpulkan bahwa klasifikasi menggunakan k-NN dapat menentukan dosis yang diperlukan tanaman padi dengan baik.