bluuebunny/crossref_metadata_2025 huggingface dataset:
CASE STUDY: IDENTIFICATION OF DESERTIFICATION IN THE YEARS 1999, 2006 AND 2011 IN MOSSORÓ-RN
Authors: Cordeiro Maryana Cavalcante , Dos Santos Nayara Arroxelas , Alcântara Silva Virgínia Mirtes , Luiz Danielle de Melo , Rodrigues da Silva Vicente de Paulo
Published: September 2022

Desertification is defined as a process of destruction of the productive potential of the land by means of the pressure exerted by human activities on fragile ecosystems, whose regeneration capacity is low. The UN classifies desertification just the damage in range located in climates semiarid, arid and sub-humid dry. This process causes three types of impacts: environmental, social and economic. The objective of this study was to evaluate the efficiency of application of the Surface Energy Balance Algorithm for Land (SEBAL) model in estimating surface albedo, temperature and vegetation index, indicators those used to assess desertification in the city of Natal, Rio Grande do Norte, making a comparison between years 1999, 2006 and 2011, having as parameter data of TM / Landsat-5. The variables studied are important weather and climate parameters in meteorological studies. The results showed that the surface albedo is increasing, temperature and vegetation index had similar behaviors in 2006, in which these two corresponded to higher values ​​than in 1999 and 2011.
ANALYSIS VEGETABLE COVERAGE OF THE HYDROGRAPHIC MICROBASIN RIACHO CHAFARIZ, THROUGH APPLICATION OF THE VEGETATION INDEX BY STANDARDIZED DIFFERENCE (IVDN)
Authors: Nascimento José Jerônimo de Souza , Góes Valéria Camboim , Silveira Thyago de Almeida , Pereira Frederico Campos
Published: September 2022

The Brazilian semiarid is characterized as an area with significant modifications in its natural aspects, mostly caused by anthropic actions to meet specific needs. However, these changes, especially in the Caatinga vegetation, occur in a way that causes environmental impacts that compromise the socioeconomic development of this geographic space. In view of this, this work has the objective of analyzing the spatiotemporal configuration of the vegetation cover in the hydrographic basin of Riacho Chafariz, for the years of 1984 and 2016. For this, LANDSAT images 5 and 8, respectively, of the dates of 17.06 were used. 1984, 25.06.2016 close to the rainy season. As methodological procedures, radiometric corrections and Normalized Difference Vegetation Index (NDVI) were used as results. NDVI maps were obtained for the years studied, where it was possible to observe important spatiotemporal changes of the vegetation cover in the microbasin. Therefore, this work was to understand the dynamics of the vegetation cover in the microbasin. In addition to promoting the development of other environmental research in this geographical area.
Zoning of the use and quality of groundwater as a subsidy for the management of water resources: The case of the urban area of the municipality of Lençóis, Bahia, Northeastern Brazil
Authors: Mattos Jonatas Batista , Silva Kaique Brito , Lima Jessé Moreira , Oliveira Lucas Athayde
Published: September 2022

The objective of this study is to zone the tubular well density and groundwater quality in the urban area of the city of Lençóis, Bahia, through geoprocessing techniques in the GIS platform. Lençóis, is a city of Chapada Diamantina, in the Brazilian Northeast that has in its territory tourism as main socioeconomic activities, receiving annually a high amount of visitors. The methodology used is based on data tabulation, kernel estimator runs for densities, and the Inverse Distance Weighted (IDW) algorithm for interpolation of nitrate and chloride contents. Both processes were executed in the ArcGis 10 software. The results showed the presence of a large zone with high density of wells in the central-east sector of the urban area of Lençóis, which presents high flow dynamics (vehicles, people), above to greater concentration of facilities such as hotels, inns, shops and restaurants. Notably, this sector has the greatest demand for water and needs to be monitored by competent institutions that seek to maintain a balance in the use of water resources, above to supply, even in periods of water stress. Inside this zone also traces of anthropic contamination occur, indicated by higher values of nitrate and chloride concentrations. This suggests that above to the pressure exerted by the high demand for water, there is inefficient management of wastewater and rainwater in this area of the urban area, compromising the quality of groundwater.
Analysis vegetable coverage of the hydrographic microbasin riacho chafariz, through application of the Normalized Difference Vegetation Index (NDVI)
Authors: Nascimento José Jerônimo de Souza , Góes Valéria Camboim , Silveira Thyago de Almeida , Pereira Frederico Campos
Published: September 2022

The Brazilian semiarid is characterized as an area with significant modifications in its natural aspects, mostly caused by anthropic actions to meet specific needs. However, these changes, especially in the Caatinga vegetation, occur in a way that causes environmental impacts that compromise the socioeconomic development of this geographic space. In view of this, this work has the objective of analyzing the spatiotemporal configuration of the vegetation cover in the hydrographic basin of Riacho Chafariz, for the years of 1984 and 2016. For this, LANDSAT images 5 and 8, respectively, of the dates of 17.06 were used. 1984, 25.06.2016 close to the rainy season. As methodological procedures, radiometric corrections and Normalized Difference Vegetation Index (NDVI) were used as results. NDVI maps were obtained for the years studied, where it was possible to observe important spatiotemporal changes of the vegetation cover in the microbasin. Therefore, this work was to understand the dynamics of the vegetation cover in the microbasin. In addition to promoting the development of other environmental research in this geographical area.
Innovation Driven by Cooperation of Startups and SME
Authors: Niever Manuel , Scholz Ilona Martina , Hahn Carsten
Published: September 2022

With rising need for innovation within a complex and dynamic world, cooperation between complementary partners offers potential to create competitive advantage. Early-stage start-ups and small and medium-sized enterprises (SMEs) can exploit opportunities by cooperating early and jointly developing new innovation. Despite research into cooperation between established start-ups and SMEs existing, there is no specific concept or support options for cooperation in an early stage. Intermediaries are named as a helpful support option; however specific tasks are not analysed. This research provides insight into various support options in the context of cooperation between early phase start-ups and the German “Mittelstand”. Within the framework of the Design Research Methodology (DRM) the results of a literature research and qualitative interviews are presented in a Reference and Impact Model, which show the need for support in the cooperation of start-ups and SMEs. Based on the findings, a four-phased cooperation process is proposed, which includes support possibilities in each individual phase. A comprehensive evaluation plan in the context of practical application completes this work. Keywords: innovation management, cooperation support, cooperation process, early-stage start-ups, open innovation
Development of the Multi-Dimensional Measure of Online Disinhibition and examination of its validity and reliability
Authors: Ruohan Wen , Miura Asako
Published: September 2022

This study aimed to develop the Multi-Dimensional Measure of Online Disinhibition (MMOD) which has a multi-dimensional perspective on the psychological processes that cause online disinhibition and evaluate its validity and reliability. In study 1, 73 items related to online disinhibition were generated from 20 semi-structured interviews. The expression of the items was modified repeatedly according to two preliminary surveys. The results showed that 25 items were screened out as preliminary MMOD. In study 2, 4-factor construction and 3-factor construction were compared according to the exploratory and confirmatory factor analysis. Finally, 3-factor (Unique perspective on online environment, change of alienation cognition and change of relationship cognition) and 12 items of the MMOD was confirmed. Correlation analysis with the prior scales showed that MMOD has good validity.
Realidade Aumentada como ferramenta tecnológica na Formação de professores de Ciências
Authors: Carvalho Mirta Cecilia Pinheiro de , Sousa Angerley de Jesus , Fraiha-Martins France
Published: September 2022

Este trabalho objetiva compreender de que maneira a realidade aumentada como ferramenta tecnológica utilizada por professores de Ciências em formação pode favorecer novas percepções sobre o ensino de Ciências, em termos conceituais e sobre o uso de tecnologias digitais em aula. Para tanto, buscamos apoio em Fernandes e Ferreira (2014), Tori (2006); Mattar (2017); Moran (2000), dentre outros. Indagamos: Em que termos a vivência de professores de Ciências em processos de formação pós-graduada, que propicia aprendizagens tecnológicas sobre a realidade aumentada, pode contribuir para novas percepções sobre o ensino de Ciências? Assumimos a abordagem qualitativa na modalidade narrativa (CLANDININ e CONNELLY, 2011), além da Análise Textual Discursiva (ATD) como metodologia analítica do material empírico. Os resultados revelam a potencialidade do uso da realidade aumentada como ferramenta tecnológica em processos de formação, pois possibilita ao professor desenvolver novas/outras percepções sobre o ensino de Ciências, bem como refletir sobre a própria prática que realiza. Nesse sentido, o professor move-se cada vez mais no processo de apropriação das tecnologias digitais disponíveis no contexto social, em busca de aproximar-se das linguagens e códigos de seus alunos com objetivos educacionais. Assim defendemos propostas dessa natureza na formação inicial e continuada de professores.
Anticipation and Contestation along the Lapsset Infrastructure Corridor in Kenya
Authors: Mkutu Kennedy
Published: September 2022

The Lamu Port-South Sudan-Ethiopia Transport (LAPSSET) corridor project is intended to traverse northern counties of Kenya, link with other corridors in Africa and attract investors. This article explores the dynamics of anticipation and how they relate to contestation over land, compensation and the benefits of development along the corridor area, finding that a variety of actors have different visions and capacities to position themselves favourably to achieve economic benefits from the corridor. Anticipatory behaviours may be both private and collective, the latter consisting of group claims on land prompted by the desire to block private actors, and also to prevent economic or political dominance by other ethnic groups. Thus both private and collective anticipation may exacerbate inequalities and lead to conflict along lines of ethnicity and class. Further, conflict may be ignited in an opportunistic manner to remove other potential beneficiaries, which is itself an example of anticipation.
DETERMINAN AUDIT REPORT LAG DENGAN PROFITABILITAS SEBAGAI VARIABEL MODERASI
Authors: Al-Faruqi Radian Atho' , Samrotun Yuli Chomsatu , Wijayanti Anita
Published: September 2022

Perusahaan yang terdaftar di Bursa Efek Indonesia (BEI) diwajibkan  memublikasikan laporan keuangan yang sebelumnya telah diaudit olek akuntan publik sebagaimana peraturan yang disahkan oleh badan pengawas pasar modal dan lembaga keuangan. Berdasarkan peraturan Otoritas Jasa Keuangan (OJK) nomor 29/PJOK.04/2016 tentang laporan tahunan emiten atau perusahaan publik pasal 7 ayat 1 menjelaskan kewajiban perusahaan dalam penyampaian laporan keuangan auditan paling lambat akhir bulan keempat setelah akhir tahun buku. Tujuan penelitian ini adalah untuk mengetahui dan menganalisis determinan Audit Report Lag dengan Profitabilitas sebagai variabel moderasi. Jenis penelitian ini adalah kuantitatif dengan menggunakan data sekunder yang diperoler dari situs resmi Indonesia Stock Exchange. Terdapat 17 sampel perusahaan sektor pertambangan yang terdaftar berturut-turut selama periode 2017-2019. Metode analisis data menggunakan Analisis Regresi Moderasi. Hasilnya menunjukan secara parsial Ukuran Perusahaan, Umur Perusahaan, Ukuran KAP tidak berpengarh terhadap Audit Report Lag, sedangkan Solvabilitas berpengaruh terhadap Audit Report Lag. Profitabilitas mampu memoderasi pengaruh Ukuran Perusahaan terhadap Audit Report lag, sedangkan Umur Perusahaan, Ukuran KAP, dan Solvabilitas tidak dapat dimoderasi oleh Profitabilitas.
Analisis Strategi Pemasaran Bank Syari'ah Berbasis Digital FINTECH terhadap Pelayanan Nasabah Bank Muamalat KCP Metro
Authors: Imelda Tri , Mahmudah Nurul , Liberty Liberty
Published: September 2022

Digital fintech service is a financial service innovation that uses or utilizes digital technology.  Bank Muamalat KCP Metro as one of the banks that already provides digital fintech-based services, namely virtual account services, cash management system, internet banking, m-banking (M-DIN), and ATMs.  The need for implementing a marketing strategy that builds customer satisfaction and trust in the service.  This study aims to determine the Marketing Strategy of Bank Muamalat KCP Metro Based on Digital Fintech for Customer Service.  This type of research is field research at Bank Muamalat KCP Metro.  This research is descriptive qualitative.  Data collection was carried out using interviews and documentation.  The data sources used were primary sources through interviews with sub-branch managers, customer service, and customers of Bank Muamalat KCP Metro, while secondary sources were obtained from documentation or literature study to complement the primary data.  Based on the research that has been done, it is known that Bank Muamalat KCP Metro has used several shari'ah marketing indicators, where the bank implements several components and the 7P marketing mix.  The most dominant marketing strategy as a bank's existence is Promotion.  Value marketing is created because of the brand, service, and process.  Bank Muamalat KCP Metro is also inseparable from the three main principles of syari'ah marketing, namely devotion, simplicity and virtue.  This principle is most dominantly applied by the marketing of Bank Muamalat KCP Metro, namely the Principle of Ketaqwaan.  Bank Muamalat KCP Metro also needs to evaluate or improve marketing strategies related to digital fintech services, it needs continuous introduction efforts to use the system effectively and efficiently because there are still customers who do not recognize Muamalat's digital fintech services, especially virtual accounts, cash management systems, internet banking.
STRATEGI BURSA EFEK INDONESIA (BEI) KANTOR PERWAKILAN LAMPUNG DALAM MENUMBUHKAN MINAT MASYARAKAT BERINVESTASI
Authors: UmpuSInga Hasrun Afandi , Imtihanah Ani Nurul , Riasari Atika
Published: September 2022

Pasar modal atau dikenal juga denga sebutan capital market merupakan tempat bertemunya penjual maupun pembeli instrumen keuangan jangka panjang yang dapat di perjualbelikan, berupa surat utang, ekuiti, reksa dana, instrumen derivatif maupun instrumen lainnya. Pasar modal adalah suatu sarana pendanaan bagi setiap perusahaan yang tergabung dalam daftar Bursa dan merupakan sarana kegiatan investasi. Pasar modal akan memfasilitasi sarana dan prasarana kegiatan jual-beli saham dan kegiatan-kegiatan terkait lainnya. Penulisan jurnal ini membahas tentang Strategi Bursa Efek Indonesia (BEI) Kantor Perwakilan Lampung dalam Menumbuhkan Minat Masyarakat dalam Berinvestasi. Strategi yang dilakukan Bursa Efek Indonesia Kantor Perwakilan Lampung diantaranya yaitu sosialisasi dan edukasi. Strategi sosialisasi dan edukasi ini memiliki beberapa maca m bentu k kegiatan, diantaranya yait u sosialisasi yang dilakukan degan target calon investor dan kepada existing investor. Kegiatan edukasi melalui kegiatan kampanye dengan slogan ‘Yu k Nabung Saham’, edukasi sekola h pasa r moda l, pelaksanaan kegiatan Foru m Calon Investo r, bekerjasama dengan instansi pemerintah maupun swasta serta membuka Klini k Investasi yaitu Galeri Investasi. Bursa Efe k Indonesia Kanto r Perwakilan Lampung disarankan agar dapat lebi h memaksimalkan hubungan kerjasama dengan Galeri Investasi maupun kepada kelompok-kelompok studi pasar modal, peneliti juga menyarankan agar Bursa Efe k Indonesia Kanto r Perwakilan Lampung lebih memaksimalkan sosialisasi produk-produ k pasa r moda l kepada masyaraka t terkhusus pada segmentasi kalangan akademisi atau kalangan muda mengingat karena pertumbuhan investor dari kalangan tersebut cukup signifikan dan kalangan tersebut dapat menjadi jembatan informasi terkait pasar modal kepada masyarakat awam. Peneliti juga menyarankan agar Bursa Efe k Indonesia Kanto r Perwakilan Lampung tetap memakai berbagai media sosia l untuk mensosialisasikan produknya di era digital seperti sekarang.
 
Kata Kunci: Strategi, Investasi, Bursa Efek Indonesia.
PENGARUH ADOPSI INTERNASIONAL FINANCIAL REPORTING STANDARD (IFRS), LEVERAGE, DAN PROFITABILITAS TERHADAP KUALITAS LABA
Authors: Putri Fanni Monada Essa , Atasoge Immawan Azhar Ben , Asrofi Imam , Avita Avita
Published: September 2022

Abstract: The purpose of this study is to explain the effect of international financial reporting standards adoption, leverage, profitability on profit quality, this type of research uses quantitative research using annual data. The population used is companies listed on the Indonesia stock exchange that adopted and have not adopted IFRS in the period 2015-2019. The regression used is OLS (Ordinary Least Square) by taking a sample of 14 companies listed on the Indonesia stock exchange. The results of this study showed that from the ifrs variable, leverage, and profitability only ifrs variables had a significant effect on the quality of profit in 14 companies on the Indonesia Stock Exchange.
Keywords: IFRS; leverage; Profit Quality.
PERANCANGAN SISTEM INFORMASI PINJAMAN DAN ANGSURAN DI KOPERASI KARYAWAN PT. INSANSANDANG INTERNUSA RANCAEKEK
Authors: Putri Dheanita Senjaya , Supriatna Encep
Published: September 2022

Based on the research done, the authors found problems in the service activities loans and installmentas that are still not yet computerized well, to increase the service these activitiesthen required a program that can handle it.Before design programs to be used to support services in the cooperative an employee of PT. Insansandang Internusa Rancaekek, writer do research by a method of descriptive using a technique data collection in observation, interview, study documentation and the literature study.Methods used to analyzes and design systems information loans and installments this is the method System Development Life Sycle (SDLC) with the model Waterfall. To analyze systems needs the use writers instrument modeling data Flowmap, Data Flow Diagram (DFD), Entity Relationship Diagram, Structure Chart dan The Lexicographer Data. While for application program the writer use software Microsoft Visual Foxpro 9.0.This system designed writer expected to assist in service and management loans and installment data, so transactions and reports necessary produces more effective and efficient.
KAJIAN MENGENAI PENERIMAAN SISTEM INFORMASI WEB PADAMU NEGERI TERHADAP PENDIDIK DAN TENAGA KEPENDIDIKAN DENGAN MENGGUNAKAN TECHNOLOGY ACCEPTANCE MODEL (TAM)
Authors: Umamah Ai
Published: September 2022

Islamic Foundation Nuurul Muttaqiin ia a private school in the Garut which is engaged in Islamic education. Charging administration teachers online or Web Padamu Negeri is an information system that is in use at the Islamic Foundation Nuurul Muttaqiin Cisurupan Garut. With the web Padamu Negeri online expect to help filling teacher administration. Charging a good data teacher is needed in order to facilitate schools and teachers to find information. In support of online data entry Padamu Negeri need support of State Information Systems and Technology quality information. The theory used in this research is the theory butterfly Behaviour Information Systems. This research method using a survey approach and the kind of research is quantitative descriptive. Data collection techniques with interviews, circulate a list of questions and study documentation. Data analysis model used amos 22 version.The population in this study were teachers in the Islamic Foundation Nuurul Muttaqiin Cisurupan Garut registered active in the web information system Padamu Negeri.Total population is 112 people and the number of samples in the meticulous 103 people. The research hypothesis testing with SEM analysis (Structural Equation Model). SEM is a statistical analysis tools in use to complete multilevel research model simultaneously. From the seven proposed hypothesis shows that there are two hypotheses are not supported. First, the Behavioral Intention to use with Actual technology use in the feel of teachers and there is no real relationship (significant). Secondly, it was felt teachers and no real relationship (significant) between the Perceived usefulness Perceived ease of use.
RANCANG BANGUN SISTEM INFORMASI PENGGAJIAN KARYAWAN (STUDI KASUS DI PT. RUMAH SAKIT PADJADJARAN JATINANGOR)
Authors: Santoso Kuwat
Published: September 2022

PT. Padjadjaran Hospital Jatinangor Division of Padjadjaran Clinic requires the handling of a work system process that is fast and accurate to meet the demands of improving the quality of its human resources that have an impact on service to patients. Because still using a manual system results in frequent data and information inaccuracies.The design of SIstem Informasi Penggajian uses design tools in the form of System Development Life Cycle (SDLC). The diagrams used include: Data Flow Diagrams, Structure Charts, Flowmaps, and E-R Diagrams. This application uses Visual Studio 2010 with Vb.Net based on client server and Database uses MySQL with good security and data integration and supports transactional programs. After going through several stages of design, this application is expected to facilitate data collection and reporting and minimize data errors and provide a smooth payroll process.As for the advantages of this payroll application is to use the finger print machine so data validation will be guaranteed and employees will obey, discipline, and employees cannot manipulate attendance data.
Spontaneous rupture of an intratumoral pseudoaneurysm in a giant renal angiomyolipoma
Authors: Abdul Malik Mawaddah , Tharek Anas , Kairuddin Faizal Firdaus , Hui Soo Tze , Ibrahim Idris , Zakaria Mohd Hazeman , Mohd Yaakob Mohd Naim
Published: September 2022

We reported a rare case of a spontaneous rupture of an intratumoral pseudoaneurysm in a giant renal angiomyolipoma of a 52-year-old lady. The initial presentation was a sudden onset of right hypochondriac pain, nausea, and vomiting. CT scan revealed large heterogenous exophytic enhancing mass with mixed solid and fat density within, arising from the right kidney likely represent a giant right renal angiomyolipoma. There is associated right perinephric hematoma and active bleeding within the mass. No features suggestive of tuberous sclerosis. Subsequent right renal angiogram revealed a pseudoaneurysm of an inferior segmental right renal artery and emergency embolization was done with successful obliteration of the aneurysmal sac and devascularization of the mass.
The Importance of the Acyltransferase Lycat on PI3K-AKT Signaling and Cancer Cell Proliferation
Authors: Chan Victoria
Published: September 2022

Phosphoinositides (PIPs) play a key role in regulating key cellular functions. PIPs are enriched with a unique acyl profile composed of stearate and arachidonate at the sn-1 and sn-2 positions, respectively, which is governed by phospholipase As and acyltransferases. Specifically, lysocardiolipin acyltransferase (LYCAT) incorporates stearic acid onto the sn-1 position. Previous work found that LYCAT silencing selectively perturbs the levels and localization of phosphatidylinositol-4,5-bisphosphate, an important precursor for phosphatidylinositol-3,4,5- trisphosphate (PIP3). PIP3 recruits and modulates the effector Akt, which promotes and coordinates cell survival and proliferation. Thus, we hypothesized that LYCAT is important in PIP3- Akt signaling and cell proliferation. Our results show that LYCAT silencing suppresses EGF- stimulated phosphorylation of Akt and select downstream substrates. Further, we observed impaired cell proliferation. Overall, our results suggest that the acyl specificity governed by LYCAT may play a significant role in controlling cell signaling and proliferation, which may have consequences for diseases such as cancer. 
Justification of the regulation of the flow of sprinklers of wide-reach circular machines
Authors: Ryazantsev Anatoly , Turapin Sergey , Evseev Evgeniy , Antipov Alexey
Published: September 2022

The article discusses the issues of substantiating the reliability of the movement of wide-reach circular sprinkler machines on elevated slopes by eliminating surface runoff in the movement zone of their running systems, especially in the end part, by equipping sprinkler machines with advanced membrane-type flow regulators. Laboratory studies have determined that the accuracy of regulation by the im-proved regulator is within the same limits as for its serial model, and is ± 5%. It has been found that the regulation of the flow rate of sprinklers in the end part of the DM on a sloping surface increases the value of the bearing capacity of the soil, from 40-50 to 80-90 kPa, or that at a specific pressure of running systems, on average, about 85 kPa, provides sufficient permeability
Részvételen alapuló társadalmi innováció Encs városban
Authors: Varga Krisztina
Published: September 2022

A tanulmány Encs város társadalmi innovációs törekvéseinek részvételi akciókutatáson alapuló vizsgálatát mutatja be. A kutatás keretein belül a társadalmi innovációt mint kreatív együttműködési folyamatot vizsgálom, amely során kiemelt figyelmet fordítok az önkormányzat által támogatott társadalmi kezdeményezések elemzésére. A tanulmány keretei között bemutatott társadalmi innovációs törekvések többszereplős, a helyi lakosság és a kutató bevonásán alapuló kezdeményezések, elemzésük lehetővé teszi a társadalmi innováció folyamatának feltérképezését. A részvételi akciókutatás módszerét a téma sajátossága, a vizsgált település speciális jellemzői alapján kiemelkedően fontosnak ítélem meg. A lakosság döntésekben való bevonása mellett kutatóként én is részt veszek az adott települések társadalmi törekvéseiben, nem csak megfigyelőként, hanem a kutatásban részvevőkkel szorosan együttműködve. Jelen tanulmány keretei között a településén vizsgált kezdeményezések bemutatására vállalkozom. A vizsgálatok alapján kijelenthető, hogy a város önkormányzata reagál a helyi igényekre, és együttműködik a helyi lakosokkal azon társadalmi innovációs kezdeményezések megvalósítása során, amelyek révén a hosszú távú megoldásokat igénylő kihívások kezelhetők.
Penilaian Kualitas Air Zona Tengah Sungai Batanghari Jambi
Authors: Gusri Lailal , Kalsum Siti Umi , Juwita Ratna
Published: September 2022

Good, clean, healthy and safe water quality is very important for the survival of humans and living creatures on earth. The application of the water quality index (WQI) method at a certain location and time can provide an assessment of water quality. This study took samples of water in the middle zone of Jambi Province which is at the Regencies: Tebo, Bungo, Sarolangun and Batanghari in order to test the water quality using Potential Hydrogen (pH), temperature, Dissolved oxygen (DO), Biological Oxygen Demand (BOD), turbidity, total phosphorus, nitrate nitrogen, E.coli and fecal coliforms as parameters. The purpose of the study was to identify river water pollutants level and to assess the ranking of the water quality index based on the application of the water quality index (WQI) method and the calculation of the CCME water quality index. The results of the test based on the water quality index method using the water quality index calculator for Tebo regency and Batanghari regency at rank 3 or moderate with the index is 53.72 and 53.28 respectively, while Bungo regency and Sarolangun regency are in rank 4 or bad with the index is 46.78 and 43.52, respectively. The overall water quality assessment for the middle zone is ranked 4 which is bad and the index is 49.77. While the calculation of the CCME water quality index shows the overall water quality of the middle zone is ranked 3, which is moderate and the index is 71.1.
Linear/Nonlinear Dynamic Analysis and Prediction of Failure Mechanism of Irgandi Bridge
Authors: Sakcalı Gökhan Barış , Gönül Alper , Bağbancı Muhammed Bilal , Yüksel İsa
Published: September 2022

The goal of this study is to investigate the behavior and failure mechanism of historical Irgandi Bridge located in Bursa City under earthquake loads by using linear and nonlinear dynamic analysis. Dynamic characteristics of the bridge is investigated by using in-situ Operational Modal Analysis (OMA) tests. The finite element model is updated according to the OMA tests. Three different artificial earthquake records from weak to very strong are applied to the model for understanding the damage zones and the failure mechanism of the historical bridge. The results show that the bridge does not reach the failure mechanism under weak earthquakes for nonlinear dynamic analysis. However, under strong earthquake even if damage zones are occurred and the stiffness of the bridge is decreased, there is no failure mechanism observed according to the nonlinear dynamic analyses. Under very strong earthquake loads the bridge reaches the failure mechanism according to the nonlinear dynamic analysis. As the earthquake level increases, the difference between linear and nonlinear dynamic analysis results increases due to structural damages. In addition, considering the soil-structure interactions, it is concluded that the dynamic characteristics could be reflected more accurately.
Business performance during the COVID-19 crisis: a major contribution of entrepreneurial resilience
Authors: Sari Puteri Andika , Sari Wiendy Puspita , Rinaldo Dito
Published: September 2022

COVID-19 affected the entire world, culminating in a devastating worldwide disaster. The crisis had a major impact on Indonesia, both in terms of health and economic concerns. As economic support in Indonesia, micro, small and medium-sized enterprises (MSMEs) are also impacted. This study was carried out in the West Java Province, including respondents among MSME actors. The aim of this study was to see how entrepreneurial resilience and self-efficacy affected company performance during the COVID-19 crisis. To assess the connection between variables, this research technique uses a quantitative methodology. The partial least squares path modeling (PLS-SEM) is used to validate the model's hypothesis, which is based on its association in a literature study done by numerous prior researchers. The findings of this study show that, as compared to entrepreneurial self-efficacy, entrepreneurial resilience has a substantial impact on MSME company performance during the COVID-19 pandemic. Based on the evaluation of the results of the research on the resilience of MSME owners, it must be supported by external variables such as government policies.
Estrategias empresariales desde la diferenciación del producto que generan ventajas competitivas para las Microempresas alimenticias comunitarias del cantón Santa Ana. Caso de estudio Microempresa NATUPAL de la Asociación San Miguel de Palo Largo.
Authors: Vera-Zambrano Andrea , Vegas-Meléndez Hilarión
Published: September 2022

La presente investigación tuvo como objetivo principal analizar las estrategias empresariales basadas en la diferenciación del producto que generan ventajas competitivas para las microempresas alimenticias comunitarias del cantón Santa Ana. Como parte del desarrollo del estudio se utilizó una metodología de carácter descriptivo, con enfoque mixto (cualitativo/cuantitativo) ya que se emplearon técnicas e instrumentos de recolección de información como la ficha de observación, entrevista y encuesta. La ficha de observación se aplicó a través de una lista de chequeo en visitas realizadas a las instalaciones de la microempresa, mientras que la entrevista estuvo dirigida a la Presidenta de la Asociación San Miguel de Palo Largo y de la Microempresa NATUPAL. Para el desarrollo de la encuesta se tomó como población a las 28 socias de la microempresa NATUPAL, a las cuales se les aplicó el formulario. Dentro de los resultados obtenidos se pudo evidenciar la situación actual de la empresa, así como conocer cuáles son las estrategias que aplican para el desarrollo de sus actividades.
Cell-tak coating interferes with DNA-based normalization of metabolic flux data
Authors: Sima M , Martinkova S , Kafkova A , Pala J , Trnka J
Published: September 2022

Metabolic flux investigations of cells and tissue samples are a rapidly advancing tool in diverse research areas. Reliable methods of data normalization are crucial for an adequate interpretation of results and to avoid a misinterpretation of experiments and incorrect conclusions. The most common methods for metabolic flux data normalization are to cell number, DNA and protein. Data normalization may be affected by a variety of factors, such as density, healthy state, adherence efficiency, or proportional seeding of cells. The mussel-derived adhesive Cell Tak is often used to immobilize poorly adherent cells. Here we demonstrate that this coating strongly affects the fluorescent detection of DNA leading to an incorrect and highly variable normalization of metabolic flux data. Protein assays are much less affected and cell counting can virtually completely remove the effect of the coating. Cell-Tak coating also affects cell shape in a cell line-specific manner and may change cellular metabolism. Based on these observations we recommend cell counting as a gold standard normalization method for Seahorse metabolic flux measurements with protein content as a reasonable alternative.
The effects of different types of exercise on circulating irisin levels in healthy individuals and in people with overweight, metabolic syndrome and type 2 diabetes
Authors: Parada-Sánchez SG , Macias-Cervantes MH , Pérez-Vázquez V , Vargas-Ortiz K
Published: September 2022

Irisin is a myokine secreted during exercise. It has drawn the attention of researchers as it regulates several effects of exercise that are considered beneficial. It has also been proposed as a therapeutic tool to treat metabolic disorders. In recent years, the effect of different types of training on circulating irisin has been studied in large populations. An overall beneficial result has been shown, however, the outcome of the investigations has raised some controversy. Herein we evaluated the existing literature on the effects of different types of training on the circulating irisin levels in healthy subjects and in those displaying different metabolic condition. We conducted queries in the PubMed and Web of Science databases for literature published between January 2010 and January 2021. Thirty-seven original articles were retrieved and they were included in this review. Any letter to the editor, meta-analyses, reviews, and systematic review articles were excluded. From these 37 articles, 19 of them reported increased levels of circulating irisin. The interventions encompassed aerobic, resistance, combined, circuit, and interval training types. Such increase of circulating irisin was reported for healthy subjects and for those displaying different metabolic condition. A training that is steadily kept with a moderate to high intensity, including that characterized by brief highly intense intervals, were distinguishable from the rest. Nevertheless, the training effectiveness as evaluated by the increased circulating irisin levels depends on the subject’s metabolic condition and age.
Bio-high entropy alloys: Progress, challenges, and opportunities
Authors: Feng Junyi , Tang Yujin , Liu Jia , Zhang Peilei , Liu Changxi , Wang Liqiang
Published: September 2022

With the continuous progress and development in biomedicine, metallic biomedical materials have attracted significant attention from researchers. Due to the low compatibility of traditional metal implant materials with the human body, it is urgent to develop new biomaterials with excellent mechanical properties and appropriate biocompatibility to solve the adverse reactions caused by long-term implantation. High entropy alloys (HEAs) are nearly equimolar alloys of five or more elements, with huge compositional design space and excellent mechanical properties. In contrast, biological high-entropy alloys (Bio-HEAs) are expected to be a new bio-alloy for biomedicine due to their excellent biocompatibility and tunable mechanical properties. This review summarizes the composition system of Bio-HEAs in recent years, introduces their biocompatibility and mechanical properties of human bone adaptation, and finally puts forward the following suggestions for the development direction of Bio-HEAs: to improve the theory and simulation studies of Bio-HEAs composition design, to quantify the influence of composition, process, post-treatment on the performance of Bio-HEAs, to focus on the loss of Bio-HEAs under actual service conditions, and it is hoped that the clinical application of the new medical alloy Bio-HEAs can be realized as soon as possible.
Sustainable alginate lyases catalyzed degradation of bio-based carbohydrates
Authors: Zheng Zhiguo , Dai Ali , Liu Yonggui , Li Tingting
Published: September 2022

Alginate is a water-soluble and acidic polysaccharide derived from the cell wall and intercellular substance of brown algae. It is widely distributed in brown algae, such as Laminaria, Sargassum, and Macrocystis, etc. Alginate lyase can catalytically degrade alginate in a β-eliminating manner, and its degradation product-alginate oligosaccharide (AOS) has been widely used in agriculture, medicine, cosmetics and other fields due to its wide range of biological activities. This article is mainly to make a brief introduction to the classification, source and application of alginate lyase. We hope this minireview can provide some inspirations for its development and utilization.
RETRACTED: Synthesis of efficient cobalt–metal organic framework as reusable nanocatalyst in the synthesis of new 1,4-dihydropyridine derivatives with antioxidant activity
Authors: Salahdin Omar dheyauldeen , Patra Indrajit , Ansari Mohammad Javed , Emad Izzat Samar , Uktamov Khusniddin Fakhriddinovich , Abid Mohammed Kadhem , Mahdi Ahmed B. , Hammid Ali Thaeer , Mustafa Yasser Fakri , Sharma Himanshu
Published: September 2022

Efficient cobalt–metal organic framework (Co-MOF) was prepared via a controllable microwave-assisted reverse micelle synthesis route. The products were characterized by SEM image, N2 adsorption/desorption isotherm, FTIR spectrum, and TG analysis. Results showed that the products have small particle size distribution, homogenous morphology, significant surface area, and high thermal stability. The physicochemical properties of the final products were remarkable compared with other MOF samples. The newly synthesized nanostructures were used as recyclable catalysts in the synthesis of 1,4-dihydropyridine derivatives. After the confirmation of related structures, the antioxidant activity of derivatives based on the DPPH method was evaluated and the relationship between structures and antioxidant activity was observed. In addition to recyclability, the catalytic activity of Co-MOF studied in this research has remarkable effects on the synthesis of 1,4 dihydropyridine derivatives.
A novel gelatin/carboxymethyl chitosan/nano-hydroxyapatite/β-tricalcium phosphate biomimetic nanocomposite scaffold for bone tissue engineering applications
Authors: Sun Qiushuo , Yu Lu , Zhang Zhuocheng , Qian Cheng , Fang Hongzhe , Wang Jintao , Wu Peipei , Zhu Xiaojing , Zhang Jian , Zhong Liangjun , He Rui
Published: September 2022

Hydroxyapatite (HA) and tricalcium phosphate (TCP) constitute 60% of the content of the bone, and their combination has a better effect on bone tissue engineering than either single element. This study demonstrates a new degradable gelatin/carboxymethyl chitosan (CMC) bone scaffold loaded with both nano-HA and β-TCP (hereinafter referred to as HCP), and freeze drying combined with stir foaming was used to obtain highly connected macropores. Only a few studies have used these components to synthesize a four-component osteogenic scaffold. The aim of this study was to comprehensively assess the biocompatibility and osteoinductivity of the nanocomposites. Three HCP/CMC/gelatin scaffolds were made with different HCP contents: group A (10 wt% HCP), group B (30 wt% HCP), and group C (50 wt% HCP) (the ratio of nano-HA and β-TCP was fixed at 3:2). The scaffolds were macroporous with a high porosity and pore connectivity, as observed by morphological analysis by scanning electron microscopy. Additionally, the pore size of groups A and B was more homogeneous than that of group C. There were no significant differences in physicochemical characterization among the three groups. The Fourier-transform infrared (FTIR) spectroscopy test indicated that the scaffold contained active groups, such as hydroxyl, amino, or peptide bonds, corresponding to gelatin and CMC. The XRD results showed that the phase structures of HA and β-TCP did not change in the nanocomposite. The scaffolds had biodegradation potential and an appreciable swelling ratio, as demonstrated with the in vitro test. The scaffolds were cultured in vitro with MC3T3-E1 cells, showing that osteoinduction and osteoconduction increased with the HCP content. None of the scaffolds showed cytotoxicity. However, cell adhesion and growth in group B were better than those in group A and group C. Therefore, freeze drying combined with a stir foaming method may have a solid component limit. This study demonstrates a novel four-component scaffold via a simple manufacturing process. Group B (30% HCP) had the best characteristics for bone scaffold materials.
Efficacy and safety of sacubitril/valsartan on heart failure with preserved ejection fraction: A meta-analysis of randomized controlled trials
Authors: Yu Wanqian , Zhang Hongzhou , Shen Wen , Luo Fan , Yang Shuai , Gan Lujin , Zhao Yuanbin , Yang Pingping , Wu Qinghua
Published: September 2022

Aims

The efficacy and safety of sacubitril/valsartan for patients with heart failure with preserved ejection fraction (HFpEF) are controversial. Hence, the primary objective of the study was to evaluate the efficacy and safety of sacubitril/valsartan treatment for patients with HFpEF.

Methods and results

We used the PubMed, Embase, and Web of Science databases to search for randomized controlled trials of sacubitril–valsartan in patients with HFpEF. Three studies, involving a total of 7,663 patients, were eligible for inclusion. Sacubitril–valsartan reduced the risk of hospitalization for heart failure (HF) [odds ratio (OR): 0.78; 95% CI: 0.70–0.88; p < 0.0001] and the incidence of worsening renal function [risk ratio (RR): 0.79, p = 0.002] among patients with HFpEF in the three trials, but there was no significant reduction in all-cause mortality (0.99, 95% CI: 0.84–1.15; p = 0.86) or cardiovascular mortality (0.95, 95% CI: 0.78–1.15; p = 0.16). Moreover, sacubitril/valsartan was associated with an increased risk of symptomatic hypotension (RR: 1.44; p < 0.00001) and angioedema (RR: 2.66; p < 0.04); there was no difference for decreasing the incidence of hyperkalemia (RR: 0.89; p = 0.11).

Conclusion

Compared with valsartan or individualized medical therapy (IMT), sacubitril/valsartan significantly decreased the risk of hospitalization for HF and reduced the incidence of renal dysfunction.
Comparison of bicuspidization and Ross procedure in the treatment of unicuspid aortic valve disease in adults – Insight from the AVIATOR registry
Authors: Gofus Ján , Karalko Mikita , Fila Petr , Ondrášek Jiří , Schäfers Hans-Joachim , Kolesár Adrian , Lansac Emmanuel , El-Hamamsy Ismail , de Kerchove Laurent , Dinges Christian , Hlubocký Jaroslav , Němec Petr , Tuna Martin , Vojáček Jan
Published: September 2022

Background

Unicuspid aortic valve (UAV) is the second most common underlying cause of aortic valve dysfunction in young adults after the bicuspid valve. The valve may be replaced (for example by pulmonary autograft) or repaired using the bicuspidization technique. The aim of our study was to compare short- and mid-term outcomes of Ross procedure with bicuspidization in patients with severe UAV dysfunction.

Methods

This was a multi-center retrospective observational cohort study comparing data from two dedicated Ross centers in the Czech Republic with bicuspidization outcomes provided by AVIATOR registry. As for the Ross group, only the patients with UAV were included. Primary endpoint was mid-term freedom from reintervention. Secondary endpoints were mid-term freedom from major adverse events, endocarditis and pacemaker implantation.

Results

Throughout the study period, 114 patients underwent the Ross procedure (years 2009-2020) and 126 patients underwent bicuspidization (years 2006-2019). The bicuspidization group was significantly younger and presented with a higher degree of dyspnea, a lower degree of aortic valve stenosis and more often with pure regurgitation. The primary endpoint occurred more frequently in the bicuspidization group than in the Ross group – 77.9 vs. 97.9 % at 5 years and 68.4 vs. 75.2 % at 10 years (p < 0.001). There was no difference in secondary endpoints.

Conclusion

Ross procedure might offer a significantly lower mid-term risk of reintervention than bicuspidization in patients with UAV. Both procedures have comparable survival and risk of other short- and mid-term complications postoperatively.
Relevance of lipoproteins, membranes, and extracellular vesicles in understanding C-reactive protein biochemical structure and biological activities
Authors: Potempa Lawrence A. , Qiu Wei Qiao , Stefanski Ashley , Rajab Ibraheem M.
Published: September 2022

Early purification protocols for C-reactive protein (CRP) often involved co-isolation of lipoproteins, primarily very low-density lipoproteins (VLDLs). The interaction with lipid particles was initially attributed to CRP’s calcium-dependent binding affinity for its primary ligand—phosphocholine—the predominant hydrophilic head group expressed on phospholipids of most lipoprotein particles. Later, CRP was shown to additionally express binding affinity for apolipoprotein B (apo B), a predominant apolipoprotein of both VLDL and LDL particles. Apo B interaction with CRP was shown to be mediated by a cationic peptide sequence in apo B. Optimal apo B binding required CRP to be surface immobilized or aggregated, treatments now known to structurally change CRP from its serum soluble pentamer isoform (i.e., pCRP) into its poorly soluble, modified, monomeric isoform (i.e., mCRP). Other cationic ligands have been described for CRP which affect complement activation, histone bioactivities, and interactions with membranes. mCRP, but not pCRP, binds cholesterol and activates signaling pathways that activate pro-inflammatory bioactivities long associated with CRP as a biomarker. Hence, a key step to express CRP’s biofunctions is its conversion into its mCRP isoform. Conversion occurs when (1) pCRP binds to a membrane surface expressed ligand (often phosphocholine); (2) biochemical forces associated with binding cause relaxation/partial dissociation of secondary and tertiary structures into a swollen membrane bound intermediate (described as mCRPmor pCRP*); (3) further structural relaxation which leads to total, irreversible dissociation of the pentamer into mCRP and expression of a cholesterol/multi-ligand binding sequence that extends into the subunit core; (4) reduction of the CRP subunit intrachain disulfide bond which enhances CRP’s binding accessibility for various ligands and activates acute phase proinflammatory responses. Taken together, the biofunctions of CRP involve both lipid and protein interactions and a conformational rearrangement of higher order structure that affects its role as a mediator of inflammatory responses.