bluuebunny/crossref_metadata_2025 huggingface dataset:
Two circPPFIA1s negatively regulate liver metastasis of colon cancer via miR-155- 5p/CDX1 and HuR/RAB36
Authors: Ji Haein , Kim Tae Won , Lee Woo Joo , Jeong Seong Dong , Cho Yong Beom , Kim Hyeon Ho
Published: June 2022

Background
Circular RNAs (circRNAs) play a critical role in colorectal cancer (CRC) progression, including metastasis. However, the detailed molecular mechanism is not fully understood.
Methods
Differentially expressed circRNAs between primary KM12C and liver metastatic KM12L4 colon cancer cells were identified by microarray. The expression of circRNAs was measured by semi-quantitative (semi-qPCR) and real time-quantitative PCR (RT-qPCR). Metastatic potential including invasive and migratory abilities, and liver metastasis were examined by transwell assays and intrasplenic injection, respectively. CircPPFIA1-associated microRNA (miRNA) and RNA-binding protein (RBP) were screened by an antisense oligonucleotide (ASO) pulldown experiment. The effects of circPPFIA1 on target gene expression were evaluated by RT-qPCR and western blot analyses.
Results
By analyzing circRNA microarray data, we identified two anti-metastatic circRNAs generated from PPFIA1 with different length, which named circPPFIA1-L (long) and -S (short). They were significantly downregulated in liver metastatic KM12L4 cells compared to primary KM12C cells. The knockdown of circPPFIA1s in KM12C enhanced metastatic potential and increased liver metastasis. Conversely, overexpression of circPPFIA1s weakened metastatic potential and inhibited liver metastasis. circPPFIA1s were found to function as sponges of oncogenic miR-155-5p and Hu antigen R (HuR) by an ASO pulldown experiment. circPPFIA1s upregulated tumor-suppressing CDX1 expression and conversely downregulated oncogenic RAB36 by decoying miR-155-5p and by sequestering HuR, respectively.
Conclusions
Our findings demonstrate that circPPFIA1s inhibit the liver metastasis of CRC via the miR-155-5p/CDX1 and HuR/RAB36 pathways.
Quality of Life in patients diagnosed with Filum Disease and Neuro-cranio-vertebral Syndrome with Arnold-Chiari Syndrome Type I, Idiopathic Syringomyelia and Idiopathic Scoliosis
Authors: Royo-Salvador Miguel B. , Luè Gioia
Published: June 2022

BackgroundFilum Disease and Neuro-cranio-vertebral syndrome are two recently described pathological concepts that comprise various diseases including Arnold-Chiari syndrome type I, idiopathic syringomyelia and idiopathic scoliosis. The objectives of this article are to describe the neuro-psychological alterations in Filum disease and Neuro-cranio-vertebral syndrome, and to carry out a descriptive analysis of how these diagnoses can influence Quality of Life and/or perception of it.MethodsWe conducted a retrospective study of the clinical anamneses of patients diagnosed with Filum Disease from a sample of 372 randomly selected patients (Sample 1) in relation to their Quality of Life. We also analysed the self-reported psychological-emotional health in 34 other patients (Sample 2). Only descriptive statistics were carried out for both samples.ResultsDespite the high frequency of pain and neurological symptoms, we detected that mood alterations and cognitive and sexual dysfunction may also be affected in Filum Disease and Neuro-cranio-vertebral syndrome. Filum Disease deteriorates Quality of Life and likely also affects patients´ perceived Quality of Life. Many patients report how the gradual and degenerative worsening of symptoms in turn progressively affects their self-assessment and self-perception of their own physical and psychological health, consequently influencing their expectations in various areas of life.ConclusionWe have shown that the Quality of Life in patients with Filum disease can be affected by the limited physical condition, mainly due to headaches or symptoms of spinal or limb pain, instability, lack of sensitivity or strength, or paresis. The consequences that Filum Disease can have on environmental and social context correspond to a further decrease in Quality of Life. For the diagnosis, prognosis, surgical treatment, and post-operative evaluation, it is essential to consider everything reported in the initial anamnesis. Otherwise, the results and effectiveness could be affected.
A new in vitro device reveals a specific influence of Arabidopsis nitrogen nutrition on its susceptibility to Alternaria brassicicola at the seedling stage
Authors: Barrit Thibault , Campion Claire , Aligon Sophie , Bourbeillon Julie , Rousseau David , Planchet Elisabeth , Teulat Béatrice
Published: June 2022

Background: Seedling growth is an early phase of plant development highly susceptible to environmental factors such as soil nitrogen (N) availability or presence of seed-borne pathogens. Whereas N plays a central role in plant-pathogen interactions, its role has never been studied during this early phase for the interaction between Arabidopsis thaliana and Alternaria brassicicola, a seed-transmitted necrotrophic fungus. The aim of the present work was to develop an in vitro device allowing to study the impact of the fungus on A. thaliana seedling growth, while modulating N nutrition.Results: The developed device consists of square plates placed vertically and filled with nutrient agar medium allowing modulation of N conditions. Seeds are inoculated after sowing by depositing a droplet of conidial suspension. A specific semi-automated image analysis pipeline based on the Ilastik software was developed to quantify the impact of the fungus on seedling aerial development, calculating an index accounting for every aspect of fungal impact, namely seedling death, necrosis and developmental delay. The device also permits to monitor root elongation. The interest of the device was then confirmed by characterising how N media composition (0.1 and 5 mM of nitrate (NO3-), 5 mM of ammonium (NH4+)) affects the impact of the fungus on three A. thaliana ecotypes. Seedling development was strongly and negatively affected by the fungus. However, seedlings grown with 5 mM NO3- were less susceptible than those grown with NH4+ or 0.1 mM NO3-, which differed from what was observed with adult plants (rosette stage).Conclusions: The developed device allows accurate determination of seedling growth characteristics (both on aerial and root parts) and symptoms. Altogether, the device could be used to study the impact of plant nutrition on susceptibility of various genotypes to fungi at the seedling stage.
Determination of EDTA-2Na in pickles and canned mix congee by a fluorescent Zirconium-Quercetin complex
Authors: Jin Di , Wang Can , Yue Xiaoqing , Wang Jun
Published: June 2022

In this study, we developed and validated a three-dimensional fluorescence method for the determination of Ethylenediaminetetraacetic acid disodium salt (EDTA-2Na) in pickles and canned mix congee by forming a ternary fluorescent complex of zirconium-quercetin-EDTA system. The conditions of complexation reaction and fluorescence scanning parameters were optimized. During the fluorescent complex reaction, NH3·H2O and anhydrous ethanol were used to enhance the fluorescence intensity. The analysis of EDTA-2Na by fluorescence scanning could be accomplished within 3 minutes. Under the condition, satisfactory linearities were obtained (R2≥0.99) with the limits of quantitation (LOQs) of 24.6 µg/g. The recoveries were 79.8-113.2%, with a relative standard deviation (RSD) below 9.7%. Compared with the HPLC-DAD method, the relative error of the two methods was less than 10%, which indicated the results of the two methods were consistent. A convenient and accurate method was established to analyze EDTA-2Na in pickles and canned mix congee, which provided a new option to rapidly monitor EDTA-2Na in foods.
CD44 as a prognostic index of brain cancers and therapeutic target of cold atmospheric plasma
Authors: Cai Linhan , Chen Yiming , Dai Xiaofeng
Published: June 2022

IntroductionBrain malignancies, including both primary and metastatic brain cancers, constitutes as one significant factor to cancer-associated mortality and poor quality-of-life of patients that remains as a global challenge in cancer research and clinical management. This study aims to identify potential biomarkers of brain cancers through pan-cancer analysis and explore potential novel therapeutic approaches. Material and methodsWe downloaded and analyzed 10 GEO datasets that satisfy our selection criterion through differentially expressed gene identification, Pearson correlation analysis, protein-protein interaction network construction, KEGG pathway and Gene Ontology term enrichment, and survival analysis. We identified independent prognostic markers on brain cancer overall survival and constructed the unified index with improved prediction power on brain cancer clinical outcome. We experimentally investigated the functionalities of the identified key marker on brain cancer cell proliferation, migration and cancer stemness, and explored the feasibility of cold atmospheric plasma in arresting brain cancer cells via targeting this identified marker.ResultsWe identified the critical role of CD44 in characterizing brain cancer malignancy, constructed a unified index involving CD44 for brain cancer prognosis, and demonstrated the efficacy of cold atmospheric plasma in arresting brain cancer cells via targeting CD44.ConclusionThe results contribute in the prognosis of brain cancer patients towards early diagnosis, intervention and precise medication, and the proposal of cold atmospheric plasma as a novel onco-therapeutic against brain cancers.
Photosynthetic usable energy explains vertical patterns of biodiversity in zooxanthellate corals
Authors: López-Londoño Tomás , Gómez-Campo Kelly , Hernández-Pech Xavier , Enríquez Susana , Iglesias-Prieto Roberto
Published: June 2022

The biodiversity in coral reef ecosystems is distributed heterogeneously across spatial and temporal scales, being commonly influenced by biogeographic factors, habitat area and disturbance frequency. In contrast to terrestrial environments, a potential association between gradients of usable energy and biodiversity has received little empirical support for explaining such patterns. Here, we analyzed the productivity and biodiversity variation over depth gradients in symbiotic coral communities, whose members rely on the energy translocated by photosynthetic algal symbionts (zooxanthellae). A mechanistic model was used to simulate the depth-dependent variation in photosynthetic usable energy to corals and explore its relationship with gradients of species diversity, comparing reefs with contrasting water clarity and biodiversity patterns along global hotspots of marine biodiversity. The productivity-biodiversity model explained between 64% and 95% of the depth-related variation in coral species richness, indicating that much of the variation in coral biodiversity with depth is driven by changes in the fractional contribution of photosynthetically fixed energy by the zooxanthellae. These results suggest a fundamental role of solar energy availability and photosynthetic productivity on global-scale patterns of coral biodiversity and community structure across depths. Accordingly, the maintenance of water optical quality is fundamental to protect coral biodiversity and prevent reef degradation, in addition to climate change mitigation policies.
Evaluation of new antimicrobial products based on potassium monopersulfate for disinfection of poultry farms
Authors: Moraes Miguel Augusto , Oliveira-Silva Mariana , Goulart Rafael Silva , Gabarra Manoel Henrique Cintra , Miranda Carlos Eduardo Saraiva , Almeida Paulo Garcia , Pitondo-Silva André
Published: June 2022

Bird drinkers used on poultry farms are highly susceptible to the formation of bacterial biofilms which can cause several diseases for animals and humans. This study evaluated the antimicrobial activity of new potassium monopersulfate-based products against bacterial biofilms. Four monopersulfate-based products named as P.A, P.B, P.C, and P.D. developed by the Hidrodomi do Brasil industry were evaluated. The products were tested against avian pathogenic Escherichia coli, Salmonella enteritidis, and Listeria monocytogenes mature biofilms. To verify the antimicrobial activity of the products, tests were initially performed against planktonic bacterial cells to determine their minimum inhibitory and bactericidal concentration. In the next step, the antimicrobial activity of the products was further evaluated in biofilms grown on acrylic specimens by counting colony-forming units (CFU) and also by employing both scanning electron microscopy (SEM) and confocal fluorescence microscopy. All products showed effectiveness against the bacterial species tested. It has been observed that P.A with concentrations lower than 0.13% presented the most effective action against planktonic cells and biofilms showing efficiency in inhibiting bacterial growth. P.A was able to completely eliminate both S. enteritidis and L. monocytogenes mature biofilms. The evaluated products, notably P. A., showed potential to be used as sanitizers and disinfectants on poultry farms.
Characterization of hepatocarcinogenesis by transcriptome and exome sequencing via chronic HBV X expression and aflatoxin B1 exposure in immortal hepatic cell
Authors: Wang Xiang-Kun , Zhou Xin , Yu Ting-Dong , Han Chuang-Ye , Zhu Guang-Zhi , Qin Wei , Huang Jian-Lu , Liao Xi-Wen , Chen Zi-Jun , Yang Cheng-Kun , Ye Xin-Ping , Peng Tao
Published: June 2022

Backgrounds:
Hepatitis B virus (HBV) and aflatoxin B1 (AFB1) exposure have synergistic effects on the occurrence and progression of hepatocellular carcinoma. In this study, we constructed HBV X (HBX) expression and AFB1 exposure models promoting hepatocarcinogenesis.
Methods
The HBX-overexpressing HL-7702 cell model was constructed by lentivirus transfection. In vitro experiments and transcriptome sequencing determined HBX functions and transcriptional traits. An interventional system containing AFB1, NAPDH, liver microsomes and medium was constructed to mimic AFB1 exposure. Transcriptome and exome sequencing identified transcriptional traits and alterations in exon regions. Differentially expressed (differential) RNAs involved in HBX overexpression, AFB1 exposure and the AFB1 + HBX exposure groups were validated by real-time polymerase chain reaction assays.
Results
HBX overexpressing showed decreased capacity for cellular migration, proliferation, invasion and clonal formation compared with control cells (P ≤ 0.05). Mutational “fingerprints” of AFB1 (TP53-R249S, AGG > AGT) and novel mutations at codons 247, 249 and 250 were unveiled in the model. Transcriptome sequencing identified the following differential RNAs: 285 mRNAs, 9 miRNAs, 78 long non-coding RNAs (lncRNAs) and 117 circular RNAs (circRNAs) in HBX group; 585 mRNAs, 143 miRNAs, 208 lncRNAs and 58 circRNAs in the AFB1 group; and 564 mRNAs, 126 miRNAs, 233 lncRNAs and 61 circRNAs in the AFB1 + HBX group. Enrichment analysis suggested the involvement of differential RNAs in angiogenesis, oxidative phosphorylation and ribosome pathways, etc. Additionally, competing endogenous RNA networks of differential mRNA-miRNA-lncRNA/circRNA cross-talk were constructed in the above groups. Exome sequencing unveiled 1061 (AFB1) and 3601 (AFB1 + HBX) single nucleotide variations, 30 (AFB1) and 40 (AFB1 + HBX) insertion and deletion alterations, 1068 (AFB1) and 138719 (AFB1 + HBX) copy number variations. The number of alterations was consistently higher in the AFB1 + HBX group compared to the AFB1 group.
Conclusions
We successfully constructed a cellular model mimicking HBX expression, AFB1 exposure and provided novel insights for understanding AFB1/HBX-related hepatocarcinogenesis.
Fractional Sumudu decomposition method for time-fractional OBBM-Burgers equation with its similarity reduction, conservation laws, and analytical solutions
Authors: AL-Denari Rasha B. , Ahmed Engy. A. , Moawad S. M. , EL-Kalaawy O. H.
Published: June 2022

The time-fractional Oskolkov-Benjamin-Bona-Mahony-Burgers (TF-OBBMB) equation is investigated in this paper. For this equation, we apply the Lie symmetry analysis to detect the symmetries and the vector fields provided using the definition of Riemann-Liouville (R-L) fractional derivatives. These symmetries allow us to construct the similarity reduction for the considered equation which converts it to a fractional ordinary differential (FOD) equation. Add to that, a set of solutions for the TF-OBBMB equation is obtained by the fractional sub-equation method. Also, we build a numerical solution by using the fractional Sumudu decomposition method in the sense of Caputo fractional derivatives accompanied by the absolute errors and the effect of the fractional-order α. Furthermore, we present a clear explanation for the physical meaning of both analytical and numerical solutions. Finally, we compute the conservation laws in detail in the light of the new conservation theorem.
The impact of antimicrobial management by clinical pharmacists in obstetrics and gynecology on antimicrobial indicators, bacterial resistance and drug costs from 2011 to 2021: a retrospective observational study
Authors: Jin Jing , Zhu JiaLei , Tang Jing
Published: June 2022

Objective: Based on the current situation of the antibiotic application in China, the clinical pharmacists continuously strengthen antibiotics application, aiming to evaluate the effectiveness and role of clinical pharmacists in antibiotics management through retrospective research from 2011 to 2021.Methods: We set up a team composed of pharmacists to carry out multi angle intervention measures, such as setting up working group, formulating plan, setting up management rules through the pre-trial system, prescription comments, jointing supervision with administrative department, carrying out training and publicity, etc. We analyzed antibiotics use, evaluated the changes of bacterial drug resistance, and counted antibiotics cost.Results: Through the pharmacists' intervention and rectification of unreasonable antibacterial drug orders, the rational utilization rate of antibiotics were significantly increased, and the cost of antibiotics was reduced. The use rate of antibiotics in clean surgery decreased from 90.22% to 11.14%, the use rate of antibiotics decreased from 63.82% to 30.26%, and the use intensity decreased from 42.75DDDs to 30.04DDDs. The varieties, time and course of antibacterials used in wards were improved to varying degrees. Bacterial drug resistance improved distinctly, such as the resistance of Escherichia coli to cephalosporins, ciprofloxacin and carbapenems decreased in varying degrees. The amount of antibacterial drugs decreased significantly.Conclusion: It is feasible and effective for pharmacists in gynecology and obstetrics to control the use of antibiotics, which plays a positive role in promoting the safe, effective and economic application of antibiotics, and provides a valuable reference on the management of antibiotics in domestic.
BVFLEMR: An Integrated Federated Learning and Blockchain Technology for Cloud-based Medical Records Recommendation System
Authors: Hai Tao , Zhou Jincheng , Srivid S.R , Jain Sanjiv Kumar , Young Praise , Agrawal Shweta
Published: June 2022

Blockchain is the latest boon in the world which handles mainly banking and finance. The blockchain is also used in the healthcare management system for the effective maintenance of electronic health and medical records. The technology ensures security, privacy, and immutability. Federated Learning is a revolutionary learning technique in deep learning, which supports learning from the distributed environment. This work proposes a framework by integrating the blockchain and Federated Deep Learning in order to provide a tailored recommendation system. The work focuses on two modules of blockchain-based storage for electronic health records, where the blockchain uses a Hyperledger fabric and is capable of continuously monitoring and tracking the updates in the Electronic Health Records in the cloud server. In the second module, LightGBM and N-Gram models are used in the collaborative learning module to recommend a tailored treatment for the patient’s cloud-based database after analyzing the EHR. The work shows good accuracy. Several metrics like precision, recall, and F1 scores are measured showing its effective utilization in the cloud database security.
Reducing the Scarcity of Fuel Wood by Utilizing Agro and Forestry Waste
Authors: Balamurugan T. , C Ezhilarasan , I Duraimurugan , K Prakash
Published: June 2022

The secure and efficient discarding of agricultural wastes is a main concern today in India. A possible solution for this waste disposal is to convert these agricultural wastes into highly compressed briquettes fuel. This research article elaborates an experimental investigation of fuel characteristics of bio-briquettes prepared by combining the palm flower with other bio wastes such as teak wood leaf, rice bran, wheat husk, tamarind shell, mango leaf and ground nut shell separately and paraffin wax as binding material. Briquettes have been made by combining 50% of palm flower with 40% of other bio wastes and 10 % of paraffin wax as binding material. Furthermore, the proximate analysis was conducted to estimate the presence of moisture, volatile matter, ash, fixed carbon along with calorific values of the biomass briquettes prepared. The results concluded that the composite biomass briquettes showed enhanced combustion properties when compared with that of different waste material. Biomass in its actual form with lower bulk density resulted in increased transportation and storage cost and it is not possible to use as it is as an efficient flammable fuel. Compacting biomass wastes under briquetting technology highly supports to minimize the above such issues and improved the combustion characteristics of the fuel which in turn may contribute to overcome the future energy crises due to the fast depletion of conventional fossil fuel.
First in-situ evidence of solar wind acceleration
Authors: Cid Consuelo , Larrodera Carlos , Flores-Soriano Manuel
Published: June 2022

Physical processes involved in the acceleration of stellar winds are essential in astrophysics as such winds are a mass loss process for stars. Hypothesis for stellar winds are difficult to check with experimental data in any other star but the Sun and even the processes of solar wind dynamics are poorly understood. Since the proposal by Parker of the stationary expansion of the solar atmosphere, the existence of the solar wind has been extensively demonstrated from data acquired from different missions in the Heliosphere. However, in-situ data showing that solar wind accelerates with the distance were still missing. Here we show the evolution of the solar wind speed distribution function with the heliocentric distance from 16 R⊙ to 172 R⊙ using Parker Solar Probe data. We observe that solar wind is accelerated until at least 60 R⊙, more than 20 R⊙ away than expected from previous studies. Below ∼ 25 R⊙ the subalfvenic wind dominates and is negligible from 35 R⊙ onwards. Here we find that the slow and fast winds are as mixed in the distribution function below 25 R⊙ as at 1 AU. Our findings provide empirical support for the models of solar wind dynamics.
Inter-rater reliability of the extended Composite Quality Score (CQS-2) - Protocol
Authors: Mickenautsch Steffen , Rupf Stefan , Miletić Ivana , Yengopal Veerasamy
Published: June 2022

Objectives: The aim of this study is to establish the inter-rater reliability of the CQS-2 and to test the null-hypotheses that it does not differ significantly from that of the first CQS version (CQS-1). Methods: Four independent raters will be selected to rate 45 clinical trial reports using CQS-1 and CQS-2. The raters will remain unaware regarding each other’s participation in this study until all rating is completed. Each rater will receive only one rating-template at a time in a random sequence for CQS-1 and CQS-2 rating. Raters will complete each template and send these back to the principal investigator via email. Each rater will receive her/his next template two weeks after submission of the completed previous template. The inter-rater reliabilities for the overall appraisal score of the CQS-1 and the CQS-2 will be established by use of the Brennan-Prediger coefficient. The coefficients of both CQS versions will be compared by use of the two-sample z-test. All data analysis will be carried out using SAS statistical software. A 5% significance level will be used. During secondary analysis, we will establish the inter-rater reliability for each single criterion and each corroboration level for both CQS versions.Reporting: The results of this study will be reported in line with the Guidelines for Reporting Reliability and Agreement Studies (GRAAS). The final report will be made available online as preprint in one of the major preprint repositories and submitted to a peer-reviewed journal.
Stress May Not Impair Higher Cognitive Functions Via Depleted Cognitive Resources
Authors: Qiu Boyu , Liu Ting , Chen Yanrong , He Xu , Zhou Cui , Zhang Wei
Published: June 2022

Whether stress impairs available cognitive resources and affects multiple cognitive functions is under debate. The current study used a relatively direct measure of available cognitive resources (i.e., the cognitive control capacity) to test the effect of acute stress and found that cognitive control capacity did not differ between conditions (stress and control) by using both the p-value and Bayes factor as indicators. We argue that stress might not impair higher cognitive functions through depleted cognitive resources after checking the effectiveness of the manipulations. The results potentially contribute to understanding the psychological consequence of stress-related disorders.
EKSISTENSI PESANTREN KHALAF DI ERA 4.0
Authors: Arif Muhamad , Aziz Mohd Kasturi Nor Abd
Published: June 2022

Abstract: Islamic boarding schools are required to be able to answer the development of the world of technology, because of the existence of the world of technology that continues to grow. So, the right response for Islamic boarding schools to follow without losing their character becomes a necessity. There are three focus problems including, How does the existence of Darul Ihsan Islamic boarding school replace Gresik in strengthening the character of students in the era of the industrial revolution 4.0,? Second, what is the role of Darul Ihsan Menganti Islamic Boarding School in Gresik in the era of the industrial revolution 4.0? and Third, what are the inhibiting factors for the Darul Ihsan Menganti Gresik Islamic Boarding School in the 4.0 era? The research uses a qualitative case study approach, data collection techniques using interviews, observation and documentation. While the data analysis from Miles and Hubarman, in the form of condensation data, display data and conclusion drawing and verification. In the process of eliminating data that is still doubtful, the panelists use triangulation of methods, sources and theories. a solid foundation in following the development of civilization, in the form of five five souls of the cottage integrated with character education, in addition, the pesantren prepares a pillar in the form of four pillars, so that both must be juxtaposed with a wall in the form of four keys in navigating life. The four important roles of pesantren include education, religion, technology and economy. There are three inhibiting factors for pesantren in carrying out their existence.
ANALISIS KEPUASAN MAHASISWA JURUSAN MANAJEMEN DAKWAH UIN SAYYID ALI RAHMATULLAH TULUNGAGUNG TERHADAP PERKULIAHAN ONLINE
Authors: Wahyudin Didin
Published: June 2022

This study aims to analyze the level of satisfaction of students of the Da'wah Management Department of UIN Sayyid Ali Rahmatullah Tulungagung with the implementation of online lectures conducted during the covid-19 pandemic. This research method uses a qualitative approach. The data were collected through questionnaires, interviews and observations on Dakwah Management students in semesters 1, 3 and 5. The collected data was then analyzed through several stages, namely the stages of data reduction, data presentation, verification and drawing conclusions. The results of this study indicate an increase in student satisfaction of the Da'wah Management Department with online lectures in the odd academic year 2021-2022. However, even though there is an increase in satisfaction with online lectures, there are still many students who want face-to-face lectures.
The Relationship between Enterprise Risk Management and Cost of Capital
Authors: Muhammad Kashif Shad  , Fong-Woon Lai  , Amjad Shamim  , Michael McShane  , Sheikh Muhammad Zahid
Published: June 2022

This paper investigates the effect of enterprise risk management (ERM) implementation on the cost of capital (cost of debt [Cd], cost of equity [Ce], and weighted average cost of capital [WACC]) for the oil and gas industry. The research is conducted using panel data analysis from 2008?2017 for 41 oil and gas companies publicly listed on the Bursa Malaysia. ERM implementation data is collected from company annual reports, while the cost of capital data is obtained from Thomson Reuters DataStream. The results indicate that an increase in the level of ERM implementation reduces the cost of capital, which we argue is one mechanism through which ERM increases firm value. Future research can use our investigation to delve deeper into ERM and value creation topics.
FOOD HABITS OF RURAL PEOPLE IN IVORY COAST
Authors:   Institute of Anthropological Development Sciences, University of Felix Houphouet-Boigny, Abidjan-Cocody., Jacob Ahouyao , Kouame Guy Marcel Bouafou ,   Department of Science and Technology, Higher School Normal Abidjan., Yao Celestin Amani ,   Institute of Anthropological Development Sciences, University Felix Houphouet-Boigny, Abidjan-Cocody.
Published: June 2022

The objective of this bibliographic synthesis is to reveal the work already done on the food habits of the rural populations of Cote dIvoire and to deduce in perspective what is to be studied in a context of climate change. It is based on secondary data sources such as: published or edited books, scientific journal articles, websites, magazines and annual reports. The eating habits of rural Ivorian people are influenced by several factors, including cultural identities, nutrition criteria, ways of preparing and consuming food, but also by disasters, crises (economic, war, etc.), climate change, etc. The food habits of rural people in Cote dIvoire are based on several foods, mostly local. Tubers (yam, taro), roots (cassava), plantain, cereals (rice, maize, millet, sorghum) are used as main dishes, prepared under various recipes (foutou, attieke, toh, placali, etc.). These main courses are accompanied by sauces made of vegetables and fruits (okra, eggplant, peanuts, palm seeds, chili peppers, tomatoes...), vegetable leaves, meat, game, fish, insects... However, these peoples have many totems, taboos and food prohibitions of animal and vegetable origin which are likely to affect their nutritional state and even their health. All these researches did not provide details on food consumption frequencies nor on resilience or adaptation measures in the context of climate change affecting agricultural yields and related commodities.
A STUDY OF EMPLOYEE SATISFACTION AND ITS IMPACT ON EMPLOYEE PERFORMANCE WITH SPECIFIC REFERENCE TO ORGANIZED RETAILING IN NAGPUR
Authors:   Assistant Professor, Department of Computer Application, Prerna College of Commerce, Nagpur., R. Deshmukh Bharti
Published: June 2022

The Employee Satisfaction Survey is part of the Strategic Framework, and will be one of several measures used to indicate overall organizational performance. Organizations spend an inordinate amount of time and energy focusing on service output, or the customer experience, often without giving thought to what the employees are experiencing along the way. The best way to realign the customer service strategy is to consider shifting your primary focus from the customer experience, to the employee experience. Employee Success and Satisfaction is an important indicator in companys success and continuous growth. This study finds out various factors underlying employee satisfaction. To achieve the aim of the study questionnaire survey was used. The results show that there is direct impact of all the factors in the organization. Job satisfaction is related to different Socioeconomic and personal factors, such as: Age, Sex, Incentives, Working Environment, Education, duration of work etc. The present paper will highlight different factors affecting job satisfaction in retails such as India retail employee such as IndiaBulls mart, Apna Bhanadar, Purti Superbazar, Big Bazar, Pyramid, and Day To Day in the Nagpur region Bulls mart, Apna Bhandar, Purti Superbazar, Big Bazar, Pyramid, and Day To Day in the Nagpur region, India.
RHETORIC SYMBOLS AS THE KEY IN ORGANIZING IDEAS OF NARRATIVE TEXTS FOUND IN DR. SEUSS CHILDREN BOOKS
Authors:   Universitas Negeri Surabaya, Indonesia., Eka Prastyawan Rikat , Purwati Oikurema ,   Universitas Negeri Surabaya, Indonesia., D. Kurnia Fabiola ,   Universitas Negeri Surabaya, Indonesia.
Published: June 2022

The aim of this research was to describe how the rhetoric symbols were reinforced to organize the Ideas of Narrative Texts found in Dr. Seuss Children Books. He had written the children books more than 60 childrens books including several of the most popular childrens narrative books of all time coming from America. This study was descriptive Qualitative by using textual analysis. The sources of data of this research were Dr. Seuss children books in the form of narrative Horton Hatches the Egg, Thidwick-the Big Hearted Moose, The Kings Stilts, and Bartholomew and the Oobleck while the data in this research were all kinds of information in the sources of data referring to the focus of research. They were analyzed synchronically and diachronically in the process of data analysis. The result showed that the rhetoric symbols were synergized to the other symbols such as animals, natures, and objects which were wrapped in the concept of id, ego, and superego through the generic structure of texts involving orientation, complication, evaluation, resolution, and coda. Its hoped it could give the contribution to the concept of creative writing especially in narrative.
EFFECT OF UPPER BODY EXERCISES ON THE PERFORMANCE OF BACKSTROKE SWIMMERS
Authors:   Research Scholar, Department of Physical Education, Banaras Hindu University,Varanasi., Saini Pradip , Onima Reddy T. ,   Research Scholar, Department of Physical Education, Banaras Hindu University,Varanasi., Singh Vikram ,   Professor, Department of Physical Education, Banaras Hindu University, Varanasi.
Published: June 2022

The purpose of the study was to clarify the Influence of 6 week selected upper body exercises on the performance of backstroke in swimming.Thirty boys swimmers (age =14 to 16 years) were randomly assigned to the experimental group (n=15) and control group (n=15). All swimmer was selected from Panchal high school, Panchal, Bankura West Bengal. Upper body exercises were included in the experimental group training session 5 times (each session 30 minutes) per week over 6 weeks as part of their usual weekly training regime. Both groups of swimmers were tested backstroke swimming before and after training. Backstroke swimming performance were tested and measured through standard procedure with the help of expert and under the direct supervision of the experimenter.For the analysis of data statistical mean, standard deviation and T-test was used. The level of significance was set at 0.05 levels. In conclusion, there was a significant effect of upper body exercise on backstroke performance of experimental group.
DEVELOPMENT AND OPTIMIZATION OF A SPECTROPHOTOMETRIC METHOD WITH CLOUD POINT EXTRACTION FOR DETERMINATION OF GADOLINIUM
Authors: Jesus Jany , Araujo Rennan , Romão Luciane
Published: June 2022

This work describes a simple, sensible, and low-cost analytical method, based on cloud-point extraction (CPE) of the surfactant (1,1,3,3-Tetramethylbutyl)phenyl-polyethylene glycol (Triton X-114), for the efficient extraction and sensible determination of gadolinium after its complexation with 1-(2-pyridylazo)-2-naphthol (PAN) and subsequent determination by ultraviolet-visible molecular absorption spectrophotometry at the wavelength of 556 nm. Full two-level and Doehlert experimental designs were applied to investigate and optimize the variables (pH, complexing concentration, and TX-114 concentration) involved in the extraction efficiency of Gd3+. The CPE was satisfactory for the determination of gadolinium with limits of detection (LoD) and quantification (LoQ) of 1.0 and 3.2 µg L-1, respectively, as well as an enrichment factor of 9.4. Accuracy was confirmed by spike tests with recovery values between 98.4 and 78.3%. The precision was expressed as relative standard deviation (%RSD, n =3), being found: 2.3% (10 µg L-1) and 2.7% (100 µg L-1). The proposed analytical method is suitable for the determination of Gd in tap water and contrast agent solutions.
Importance of Aberrant Right Subclavian Artery Detection During Second Trimester Ultrasound Examination in Low-Risk Population
Authors: Seker Erdal , Sut Hasan , Kocar Mustafa , Umit Coskun , Ozkavukcu Esra , Koc Acar
Published: June 2022

OBJECTIVE: Aberrant right subclavian artery, which is detected in 1-1.5% of the population, is considered an anatomical variant. Aberrant right subclavian artery is usually not symptomatic, but can sometimes lead to dysphagia due to esophageal compression. On the other hand, it has been found that it has accompanied some fetal anomalies in the last two decades. Although aberrant right subclavian artery is seen at a rate of 1-1.5% in normal chromosomal fetuses, it is seen at a rate of 19-36%, especially in fetuses with Down syndrome.
STUDY DESIGN: Our study was carried out in the Department of Obstetrics and Gynaecology at Ankara University Faculty of Medicine between the dates of January 2017-January 2020. Pregnant women have had their detailed ultrasonography at our clinic and who were between 18th-24th gestational weeks were included. Amniocentesis was performed on the patients who have accepted, and genetic results were followed up. The patients who did not accept were followed up until after birth, and genetic testing was requested for babies suggestive of anomaly.
RESULTS: Our study included 6205 patients who underwent detailed ultrasonography in our clinic between January 2017 and June 2020. Our detailed ultrasonography application week was between 16-24 weeks. During this period, aberrant right subclavian artery was detected in 47 of our patients. The detection rate of ARSA in the normal population in our study was 0.7% (46/6205). While aberrant right subclavian artery was the only ultrasonographic finding in 28 patients, extra anomalies were observed in 18 patients. Down syndrome was detected in four fetuses,
CONCLUSION: We did not find any chromosomal anomalies in any of the patients with isolated aberrant right subclavian artery. Therefore, we do not recommend invasive intervention in patients with isolated aberrant right subclavian artery. On the other hand, our study confirmed that aberrant right subclavian artery screening should be a part of a detailed fetal ultrasonographic examination. Further studies with larger patient groups are needed.
The Potential of Naturally Occurring Antibiotic Peptides to from Coiled-Coils
Authors: Wade David
Published: June 2022

The amino acid sequences of 183 naturally occurring, antibiotic peptides were analyzed for the presence of characteristic features associated with the coiled-coil motif. Most sequences contained some of these features, but no single peptide contained all of them. The results indicate that these peptides probably cannot aggregate as coiled-coils, and they have implications for models of the mechanisms of antibiotic action.
Crystallisation and Preliminary X-Ray Diffraction Studies on Human Liver Aldolase
Authors: Dalby A. , Rawas A. , Watson H.C. , Littlechild J.A.
Published: June 2022

Human liver aldolase has been crystallised from an over-expressed protein in the space group 1212121 with unit cell dimensions a = 189.0 A, b = 59.5 A and c = 155.2 A, α = β= γ= 90°. The strncture has been solved by molecular replacement at 3.8 A resolution using human muscle aldolase as an initial model.
Isolation and in vitro Cleavage Specificities of Epidermal Growth Factor Binding Proteins
Authors: Beg Obaid U. , Uddin Mukarram
Published: June 2022

Results of the present investigation indicate the presence of three mouse epidermal growth factor binding proteins (EGF-BP-A, -Band -C) in BPN strain of mice . All of these proteases show specificity towards Arg­ Val and Tyr-Ser bonds which appears, inpart, to be dependent on adjacent amino acids.Additionally EGF-BP­ A also cleaves Lys-Val and Leu-Ser bonds; EGF-BP-B cleaves Lys-Ala bond and EGF-BP-C cleaves Lys-Val and Lys-Aia bonds. These cleavages distingui sh EGF-BP's from each other.
Stimulation of Non-Specific Resistance by Human Casein Fragment (54-59) and its Synthetic Analogues against Leishmania Donovani Infection+.
Authors: Sharma P. , Anuradha  , Sharan R. , Haq W. , Kundu B. , Katiyar J.C. , Mathur K.B.
Published: June 2022

The prophylactic effect of human β casein fragment (54-59) and its synthetic congeners has been studied against L. donovani infection in hamsters. Maximum parasite inhibition (84%) was observed with compound 4. The activity of this compound was further confirmed in vitro
Conformational Behaviour of an Analogue of the S-Peptide: A Molecular Dynamics Study
Authors: Abruscato Vincenzo , Ranghino Graziella , Maria Villa Anna
Published: June 2022

The S-peptide, derived from the hydrolysis of Ribonuclease, is a stable a.-helix in water, although it is only 20 amino acids long. In view of increasing the helical content and stability, a mutated sequence has been proposed. The present work aims to shed light on the conformational preferences and on the helix stability of the proposed sequence by means of Molecular Dynamics simulations performed with different procedures.
Three-dimensional Self-organization of Tetraphenylporphyrin and its Composites with C60: Structure and Optical Properties
Authors: Elistratova Marina , Romanov Nikolay , Zakharova Irina
Published: June 2022

Background:

Thin films of a 5,10,15,20-tetraphenylporphyrin (H2TPP) and its metal
complexes (MeTPP, where Me = Co, Cu, Zn, Fe-Cl) were obtained by vacuum thermal evaporation
under quasi-equilibrium conditions (hot wall method) and by coating from a toluene solution
on various substrates. It was shown that H2TPP, CuTPP and CoTPP have an ability to selforganization
into linear structures during crystallization (nanowhiskers, nanowires, or nanorods),
regardless of our obtaining method.

Methods:

FeClTPP and ZnTPP crystallize into planar films with the same preparation technique.
Co-deposition with fullerene C60 allows obtaining fullerene crystallites on the surface of
tetraphenylporphyrin, subsequently creating the so-called bulk heterojunctions.

Results:

The possibility of controlling the shape of obtained crystallites by changing technological
parameters and substrates has been shown for metal free tetraphenylporphyrin. High degree
crystalline ZnTPP and H2TPP films are characterized by a red shift of photoluminescence and
absorption spectra under crystallization.

Conclusion:

A change in the relative intensity of the photoluminescence spectrum maxima of
various nature is observed during transition from amorphous to crystalline structure of H2TPP.
Role of the Gut Microbiome in Diabetes and Cardiovascular Diseases
Including Restoration and Targeting Approaches- A Review
Authors: Ahuja Alka , UM Dhanalekshmi , MP Saraswathy , S Nandakumar , F Arul Prakash , KN Gurpreet
Published: June 2022

Metabolic diseases, including cardiovascular diseases (CVD) and diabetes, have become the leading cause of morbidity and mortality worldwide. Gut microbiota appears to play a
vital role in human disease and health, according to recent scientific reports. The gut microbiota
plays an important role in sustaining host physiology and homeostasis by creating a cross-talk
between the host and microbiome via metabolites obtained from the host's diet. Drug developers
and clinicians rely heavily on therapies that target the microbiota in the management of metabolic diseases, and the gut microbiota is considered the biggest immune organ in the human
body. They are highly associated with intestinal immunity and systemic metabolic disorders like
CVD and diabetes and are reflected as potential therapeutic targets for the management of metabolic diseases. This review discusses the mechanism and interrelation between the gut microbiome and metabolic disorders. It also highlights the role of the gut microbiome and microbially
derived metabolites in the pathophysiological effects related to CVD and diabetes. It also spotlights the reasons that lead to alterations of microbiota composition and the prominence of gut
microbiota restoration and targeting approaches as effective treatment strategies in diabetes and
CVD. Future research should focus onunderstanding the functional level of some specific microbial pathways that help maintain physiological homeostasis, multi-omics, and develop novel
therapeutic strategies that intervene with the gut microbiome for the prevention of CVD and
diabetes that contribute to a patient's well-being.
Análisis del aporte del aprendizaje de máquinas a la seguridad de la información
Authors: Correa Wachter Juan Fernando , Henao Villas Cesar Felipe , Henao Villa Federico , García Arango David Alberto
Published: June 2022

Every computing device has its own security logs. Byaggregating thousands of devices that intervene in thecommunications of personal computers, databases, webservers, network devices, firewalls, etc., a large volume oflogs is generated with interesting information from thesecurity point of view, although impossible to review by ahuman. That is where it has automated tools with a certainintelligence capable of performing analyzes and detectingmalicious patterns that can affect the confidentiality,integrity and availability of information.Among these tools arise Artificial Intelligence and MachineLearning, which are being included by manufacturers inthe latest generation security products. The objective ofthis article is to explain what Machine Learning consists of,its history, components and its contribution in support ofinformation security.
Implementación de un prototipo funcional de sistema biométrico para el control de asesorías de proyectos integradores
Authors: Delgado Córdoba Elkin Alcibíades , Andrea Castañeda Paula , Parra Bohórquez Yeimmi , Henao Villa Cesar Felipe , García Arango David Alberto
Published: June 2022

In the present applied research, the attendance taking wasdigitized, improving the effectiveness and efficiency of saidtaking, through the use of biometric devices connected toa database supported on a platform specifically designedfor said task, providing an adequate control tool andconsultation, both for teachers, students and other members of the competent academic body to access the information that is stored automatically and in real time, when reporting attendance in the fingerprint reader located in the place of counseling defined by the staff in charge. This project improved the quality of the data collection process of assistance to theconsultancies of the integrative projects by the teacher to the students, who should occupy an assigned place according to the corresponding days and hours. With the present applied research, it was possible to facilitate registration through fingerprint readers, implemented and supported on innovative technology, properly programmed for this purpose, providing a higher level of confidence in terms of the veracity of the information entered and at the time of registration. consultation, since it is very difficult to falsify a fingerprint, this would give a greater degree of confidence in the information.
Préface
Authors: Laurent Dominique
Published: June 2022

Préface