bluuebunny/crossref_metadata_2025 huggingface dataset:
Treatment approach in patients with hyperbilirubinemia secondary to liver metastases in gastrointestinal malignancies: a case series and review of literature
Authors: Quidde Julia , Azémar Marc , Bokemeyer Carsten , Arnold Dirk , Stein Alexander
Published: March 2016

Background:

Treatment of patients with severe liver dysfunction including hyperbilirubinemia secondary to liver metastases of gastrointestinal (GI) cancer is challenging. Regimen of oxaliplatin and fluoropyrimidine (FP)/folinic acid (FA) ± a monoclonal antibody (moAb), represents a feasible option considering the pharmacokinetics. Clinical data on the respective dosage and tolerability are limited and no recommendations are available.

Methods:

Consecutive patients with severe hyperbilirubinemia [>2 × upper limit of the normal range (ULN) and >2.4 mg/dl] due to liver metastases of GI cancer without options for drainage receiving oxaliplatin, FP/FA ± moAb were analyzed. To collect further data a review of the literature was performed.

Results:

A total of 12 patients were identified between 2011 and 2015. At treatment start, median bilirubin level was 6.1 mg/dl (>5 × ULN, range 2.7–13.6). The majority of patients ( n = 11) received dose-reduced regimen with oxaliplatin (60–76%) and FP/FA (0–77%), rapidly escalating to full dose regimen. During treatment, bilirubin levels dropped more than 50% within 8 weeks or normalized within 12 weeks in 6 patients (responders). Median overall survival was 5.75 months (range 1.0–16.0 months) but was significantly prolonged in responders compared to nonresponders [9.7 and 3.0 months, p = 0.026 (two-sided test); 95% confidence interval (CI): 1.10–10.22]. In addition, case reports or series comprising a further 26 patients could be identified. Based on the obtained data a treatment algorithm was developed.

Conclusion:

Treatment with oxaliplatin, FP/FA ± moAb is feasible and may derive relevant benefits in patients with severe liver dysfunction caused by GI cancer liver metastases without further options of drainage.
Safety of coil occlusion of the parent artery for endovascular treatment of anterior communicating artery aneurysm
Authors: Kim Sanghyeon , Kang Myongjin , Choi Jae-Hyung , Kim Dong Won
Published: March 2016

Many studies lay emphasis on the clinical importance of perforating branches of the anterior communicating artery (ACoA) and report that vascular damage of the perforators from ACoA aneurysm during surgery cause subsequent postoperative amnesia. The purpose of our study was to analyze the safety of parent artery occlusion for ACoA aneurysm coiling based on the anatomical features of the ACoA complex in 13 patients with 13 ACoA aneurysms. All patients underwent coiling of the aneurysm sac and ACoA. Aneurysm characteristics including size, dome-to-neck ratio, anterior/posterior orientation of the aneurysm dome with respect to the axis of the pericallosal artery, location of the aneurysm neck with respect to the A1–A2 segment of the anterior cerebral artery (ACA) or the ACoA, and the presence of hypoplasia/aplasia of A1 segment were assessed. The aneurysm neck was located directly on the ACoA in five aneurysms (38%), whereas eight (62%) had the neck located at the A1–A2 junction. Of the five patients whose aneurysm neck was located in the ACoA, four patients had infarcts in the basal forebrain. Three of the patients complained of amnesia. None of the aneurysms with the neck located at the A1–A2 junction were associated with infarction. There has been little evidence thus far that parent vessel occlusion of ACoA aneurysms is a safe method for the treatment of aneurysms. Patients with the aneurysm neck located at the A1–A2 junction and without A1 aplasia, who were treated with aneurysm sac and ACoA embolism, were potentially safe.
Mogamulizumab for the treatment of cutaneous T-cell lymphoma: recent advances and clinical potential
Authors: Duvic Madeleine , Evans Mark , Wang Casey
Published: March 2016

Mogamulizumab (KW-0761) is a humanized immunoglobulin G1 (IgG1) monoclonal antibody (mAb) that targets CC chemokine receptor 4 (CCR4). It has shown promising therapeutic potential in phase I and II clinical trials and is currently being investigated for efficacy in treating cutaneous T-cell lymphoma (CTCL). We review the mechanism of action of mogamulizumab and its role in treating CTCL. We also discuss the results of major clinical trials.
The Prognostic Validity of the Timed Up and Go Test With a Dual Task for Predicting the Risk of Falls in the Elderly
Authors: Hofheinz Martin , Mibs Michael
Published: March 2016

Objective: The aim is to examine the prognostic validity of the Timed Up and Go Test with a cognitive and a manual dual task for predicting the risk of falls. Method: A follow-up study was performed. The data were recorded for 120 volunteers in an outpatient physiotherapy center, with a 12-month follow-up. The sample included 120 elderly men and women aged 60 to 87 years ( M age = 72.2 years) living at home. The main measurements were as follows: The Timed Up and Go Test (TUG), the TUG with a cognitive dual task (TUGcog), and the TUG with a manual dual task (TUGman) and falls. Results: In the 12-month follow-up, 37 persons (30.8%) had a locomotive fall. The receiver operating characteristic (ROC) curve shows significant results for the TUGcog. The area under the curve is 0.65 ( p = .008), with a 95% confidence interval (CI) = [0.55, 0.76]. For the TUGman, the area under the curve is 0.57 with a 95% CI = [0.45, 0.68], which is not significant ( p = .256). For the TUG, the area under the curve is 0.58, which is not significant ( p = .256), 95% CI = [0.47, 0.69]. Conclusion: The TUGcog is a valid prognostic assessment to predict falls in community-dwelling elderly people.
Innovation and Creating Shared Value: The Highly Effective Habits of Innovative Organizations
Authors: Drummond-Dunn Denyse
Published: March 2016

Innovation is vital to the continued success of any business. Customers no longer stay satisfied for long. They are looking to be surprised and delighted by most, if not all, of the products and services they buy.

Today’s challenge is to find ways to better and more quickly satisfy these ever-increasing demands of our customers. Adopting the three highly effective habits laid out in this article provide a clear roadmap. These include setting stretch targets for every new launch, regular connection with and observation of customers, and the expansion of idea generation to greater input from both internal and external sources.

These are the three essential elements that make innovation of increased value to both customers and companies. Customers get more of what they want, need and sometimes what they have only dreamed of having. Organizations see greater loyalty and satisfaction, easier acceptance of price increases and a better understanding of both the current market and the future potential of new categories.

In summary, this article shows that successful innovation and creating shared value go hand-in-hand in today’s connected world.
Diagnosis of Iatrogenic Injury of the Endometrium Using Duplex Sonography
Authors: Nanni Garth S. , Degli-Antoni Karen , Camacho Damaris , Wall Thomas
Published: March 2016

Iatrogenic endometrial arterial injury is a rare and life-threatening condition that can occur after dilation and curettage (D&C) procedures. A case is presented that describes the sonographic features of an iatrogenic endometrial arterial injury status post-D&C. The patient presented to the emergency department on several occasions for post-D&C complaints. The patient was imaged with transabdominal and transvaginal grayscale and Doppler (color and spectral) sonography on all visits. Other diagnostic testing, such as beta human chorionic gonadotropin (B-hCG) levels, also was performed. The report dictated by the radiologists considered multiple differential diagnoses, with the findings showed by sonography suggesting that the diagnosis was most consistent with an arteriovenous fistula. A follow-up sonogram at 3 months demonstrated resolution of this condition, which was present in the first 2 emergency department visits.
Initial dual oral combination therapy in pulmonary arterial hypertension
Authors: Sitbon Olivier , Sattler Caroline , Bertoletti Laurent , Savale Laurent , Cottin Vincent , Jaïs Xavier , De Groote Pascal , Chaouat Ari , Chabannes Céline , Bergot Emmanuel , Bouvaist Hélène , Dauphin Claire , Bourdin Arnaud , Bauer Fabrice , Montani David , Humbert Marc , Simonneau Gérald
Published: March 2016

Treatment for pulmonary arterial hypertension (PAH) has been underpinned by single-agent therapy to which concomitant drugs are added sequentially when pre-defined treatment goals are not met.

This retrospective analysis of real-world clinical data in 97 patients with newly diagnosed PAH (86% in New York Heart Association functional class III−IV) explored initial dual oral combination treatment with bosentan plus sildenafil (n=61), bosentan plus tadalafil (n=17), ambrisentan plus tadalafil (n=11) or ambrisentan plus sildenafil (n=8).

All regimens were associated with significant improvements in functional class, exercise capacity, dyspnoea and haemodynamic indices after 4 months of therapy. Over a median follow-up period of 30 months, 75 (82%) patients were still alive, 53 (71%) of whom received only dual oral combination therapy. Overall survival rates were 97%, 94% and 83% at 1, 2 and 3 years, respectively, and 96%, 94% and 84%, respectively, for the patients with idiopathic PAH, heritable PAH and anorexigen-induced PAH. Expected survival rates calculated from the French equation for the latter were 86%, 75% and 66% at 1, 2 and 3 years, respectively.

Initial combination of oral PAH-targeted medications may offer clinical benefits, especially in PAH patients with severe haemodynamic impairment.
Bottom-up GGM algorithm for constructing multilayered hierarchical gene regulatory networks that govern biological pathways or processes
Authors: Kumari Sapna , Deng Wenping , Gunasekara Chathura , Chiang Vincent , Chen Huann-sheng , Ma Hao , Davis Xin , Wei Hairong
Published: March 2016

Background

Multilayered hierarchical gene regulatory networks (ML-hGRNs) are very important for understanding genetics regulation of biological pathways. However, there are currently no computational algorithms available for directly building ML-hGRNs that regulate biological pathways.

Results

A bottom-up graphic Gaussian model (GGM) algorithm was developed for constructing ML-hGRN operating above a biological pathway using small- to medium-sized microarray or RNA-seq data sets. The algorithm first placed genes of a pathway at the bottom layer and began to construct a ML-hGRN by evaluating all combined triple genes: two pathway genes and one regulatory gene. The algorithm retained all triple genes where a regulatory gene significantly interfered two paired pathway genes. The regulatory genes with highest interference frequency were kept as the second layer and the number kept is based on an optimization function. Thereafter, the algorithm was used recursively to build a ML-hGRN in layer-by-layer fashion until the defined number of layers was obtained or terminated automatically.

Conclusions

We validated the algorithm and demonstrated its high efficiency in constructing ML-hGRNs governing biological pathways. The algorithm is instrumental for biologists to learn the hierarchical regulators associated with a given biological pathway from even small-sized microarray or RNA-seq data sets.
RETRACTED ARTICLE: CDK4 and miR-15a comprise an abnormal automodulatory feedback loop stimulating the pathogenesis and inducing chemotherapy resistance in nasopharyngeal carcinoma
Authors: Liu Zhen , Cheng Chao , Luo Xiaojun , Xia Qiong , Zhang Yejie , Long Xiaobing , Jiang Qingping , Fang Weiyi
Published: March 2016

Background

In previous investigation, we reported that stably knocking down cyclin-dependent kinase 4(CDK4) induced expression of let-7c, which further suppressed cell cycle transition and cell growth by modulating cell cycle signaling in nasopharyngeal carcinoma (NPC). In this study, we further explored the molecular function and mechanism of CDK4 modulating miRNAs to stimulate cell cycle transition, cell growth, and Cisplatin (DDP) -resistance on in NPC.

Methods

We identified changes in miRNAs by miRNA array and real-time PCR and the effect on DDP after knocking down CDK4 in NPC cells. Further, we investigated the molecular mechanisms by which CDK4 modulated miR-15a in NPC. Moreover, we also explored the role of miR-15a and the effect on DDP in NPC. Finally, we analyzed the correlation of miR-15a and CDK4 expression in NPC tissues.

Results

In addition to let-7 family members, we observed that upregulated expression of miR-15a was significantly induced in CDK4-suppressed NPC cells. Further, we found that knocking down CDK4 suppressed c-Myc expression, and the latter directly suppressed the expression of miR-15a in NPC. Furthermore, miR-15a as a tumor suppressor antagonized CDK4 repressing cell cycle progression and cell growth in vitro and in vivo and induced the sensitivity of cells to DDP by regulating the c-Myc/CCND1/CDK4/E2F1 pathway in NPC. Finally, miR-15a was negatively weak correlated with the expression of CDK4 in NPC.

Conclusions

Our studies demonstrate that CDK4 and miR-15a comprise an abnormal automodulatory feedback loop stimulating the pathogenesis and inducing chemotherapy resistance in NPC.
Fixed points of generalized Meir-Keeler contraction mappings in b-metric-like spaces
Authors: Gholamian Nayereh , Khanehgir Mahnaz
Published: March 2016

In this paper, we introduce the notion of generalized Meir-Keeler contraction mappings in the setup of b-metric-like spaces. Then we establish some fixed point results for this class of contractions. We also provide some examples to verify the effectiveness and applicability of our main results.
Coupled coincidence and coupled common fixed point theorems on a metric space with a graph
Authors: Eshi Dakjum , Das Pramod K , Debnath Pradip
Published: March 2016

In this paper, our aim is to introduce the concept of G-g-contraction mapping and prove some coupled coincidence and coupled common fixed point theorems for nonlinear contraction mappings in the new set up of partially ordered complete metric spaces endowed with a directed graph. As an application, we apply our results to present an existence theorem for solution of some particular integral equations. Our paper is inspired by the work of Chifu and Petrusel (Fixed Point Theory Appl. 2014:151, 2014); the authors introduced the concept of a coupled fixed point. In the current paper, however, we have established the results by introducing the new notion of a coupled coincidence fixed point instead of the coupled fixed point in the setting of a partially ordered complete metric space with graph.
Does the gender composition of forest and fishery management groups affect resource governance and conservation outcomes? A systematic map
Authors: Leisher Craig , Temsah Gheda , Booker Francesca , Day Michael , Samberg Leah , Prosnitz Debra , Agarwal Bina , Matthews Elizabeth , Roe Dilys , Russell Diane , Sunderland Terry , Wilkie David
Published: March 2016

Background

Women often use natural resources differently than men yet frequently have minimal influence on how local resources are managed. An emerging hypothesis is that empowering more women in local resource decision-making may lead to better resource governance and conservation. Here we focus on the forestry and fisheries sectors to answer the question: What is the evidence that the gender composition of forest and fisheries management groups affects resource governance and conservation outcomes? We present a systematic map detailing the geographic and thematic extent of the evidence base and assessing the quality of the evidence, as per a published a priori protocol.

Methods

We screened 11,000+ English-language records in Scopus, CAB abstracts, AGRIS, AGRICOLA, Google Scholar, and Google. The websites of 24 international conservation and development organisations, references of included articles, and relevant systematic reviews were also searched for possible documents. A number of groups and individuals were invited to submit documents through email ‘call outs’. The inclusion criteria were that an article refers to women or gender, forests or fisheries, and a resource management group comparison in a non-OECD country plus Mexico and Chile.

Results

Seventeen studies met the inclusion criteria. Four were qualitative and 13 were quantitative. Forest studies outnumbered fisheries studies 14–3. The majority of the studies came from India and Nepal and focused on forest management. All 17 studies identified improvements in local natural resource governance, and three identified conservation improvements when women participated in the management of the resources. Only two studies, however, were rated as high quality based on study design.

Conclusions

For India and Nepal, there is strong and clear evidence of the importance of including women in forest management groups for better resource governance and conservation outcomes. Outside of India and Nepal, there are substantial gaps in the evidence base, but the South Asian evidence presents a compelling case for extending the research to other geographies to see if similar outcomes exist elsewhere and supports a theory of change linking the participation of women in forestry and fisheries management groups with better resource governance and conservation outcomes.
Depurinating estrogen‐DNA adducts, generators of cancer initiation: their minimization leads to cancer prevention
Authors: Cavalieri Ercole L. , Rogan Eleanor G.
Published: March 2016

Estrogens can initiate cancer by reacting with DNA. Specific metabolites of endogenous estrogens, the catechol estrogen‐3,4‐quinones, react with DNA to form depurinating estrogen‐DNA adducts. Loss of these adducts leaves apurinic sites in the DNA, generating mutations that can lead to the initiation of cancer. A variety of endogenous and exogenous factors can disrupt estrogen homeostasis, which is the normal balance between estrogen activating and protective enzymes. In fact, if estrogen metabolism becomes unbalanced and generates excessive catechol estrogen 3,4‐quinones, formation of depurinating estrogen‐DNA adducts increases and the risk of initiating cancer is greater. The levels of depurinating estrogen‐DNA adducts are high in women diagnosed with breast cancer and those at high risk for the disease. High levels of depurinating estrogen‐DNA adducts before the presence of breast cancer indicates that adduct formation is a critical factor in breast cancer initiation. Women with thyroid or ovarian cancer also have high levels of estrogen‐DNA adducts, as do men with prostate cancer or non‐Hodgkin lymphoma. Depurinating estrogen‐DNA adducts are initiators of many prevalent types of human cancer. These findings and other discoveries led to the recognition that reducing the levels of estrogen‐DNA adducts could prevent the initiation of human cancer. The dietary supplements N‐acetylcysteine and resveratrol inhibit formation of estrogen‐DNA adducts in cultured human breast cells and in women. These results suggest that the two supplements offer an approach to reducing the risk of developing various prevalent types of human cancer.
A momentary biomarker for depressive mood
Authors: Kim Jinhyuk , Nakamura Toru , Yamamoto Yoshiharu
Published: March 2016

Many biomarkers from genetic, neuroimaging, and biological/biochemical measures have been recently developed in order to make a shift toward the objective evaluation of psychiatric disorders. However, they have so far been less successful in capturing dynamical changes or transitions in pathological states, such as those occurring during the course of clinical treatments or pathogenic processes of disorders. A momentary biomarker is now required for objective monitoring of such dynamical changes. The development of ecological momentary assessment (EMA) allows the assessment of dynamical aspects of diurnal/daily clinical conditions and subjective symptoms. Furthermore, a variety of validation studies on momentary symptoms assessed by EMA using behavioral/physiological/biochemical measures have demonstrated the possibility of evaluating momentary symptoms from such external objective measures. In this review, we introduce physical activity as a candidate biobehavioral biomarker for psychiatric disorders. We also mention its potential as a momentary biomarker for depressive mood. Finally, we address the continuous monitoring of the pathogenic processes and pathological states of depressive disorders based on physical activity, as well as its application in pharmacological animal studies.
Comparisons: women’s garments manufacturing cost survey between Korea and China
Authors: Kim Myoung-Ok , Lee Youn Hee , Martins Lilian Parreiras , Wen Yingyu
Published: March 2016

This study aims to survey general information from garment factories in South Korea and China, representing, respectively, a developed country and a developing country. Additionally, within the same two countries, the study surveys garment manufacturing costs, from low to high, for a both a “basic” as well as for a “detailed” blouse, pants, and jacket (total of six items), with a goal of determining of an estimation of manufacturing cost in 2018. The results showed that there were meaningful differences between South Korea and China, as expected. Significant differences were shown in the number of employees, monthly wages, effecting factors on the lowest cost price period for a year; garment manufacturing time, and manufacturing costs of basic designs and detailed designs of blouse, pants, and jacket. The results of garments cost were significantly different consistent with the quality, from low cost to high cost, and quantities, from 500 pieces or less to above 10,000 pieces. The overall cost difference between two counties was about 2.6–3.5 times greater (Korea to China). Examining the same item, the difference was larger in low quality and small or large quantity rather than high quality and medium quantity. Interestingly, pants and jackets showed the largest cost difference at quantities above 10,000 pieces. Also, for 2018 there were differences in the estimated costs between both countries. The estimated cost differences were increasing from 2013 giving the implication that future manufacturing cost could increase between Korea and China.
Planar Cell Polarity (PCP) Protein Vangl2 Regulates Ectoplasmic Specialization Dynamics via Its Effects on Actin Microfilaments in the Testes of Male Rats
Authors: Chen Haiqi , Mruk Dolores D. , Lee Will M. , Cheng C. Yan
Published: March 2016

Planar cell polarity (PCP) proteins confer polarization of a field of cells (eg, elongating/elongated spermatids) within the plane of an epithelium such as the seminiferous epithelium of the tubule during spermatogenesis. In adult rat testes, Sertoli and germ cells were found to express PCP core proteins (eg, Van Gogh-like 2 [Vangl2]), effectors, ligands, and signaling proteins. Vangl2 expressed predominantly by Sertoli cells was localized at the testis-specific, actin-rich ectoplasmic specialization (ES) at the Sertoli-spermatid interface in the adluminal compartment and also Sertoli-Sertoli interface at the blood-testis barrier (BTB) and structurally interacted with actin, N-cadherin, and another PCP/polarity protein Scribble. Vangl2 knockdown (KD) by RNA interference in Sertoli cells cultured in vitro with an established tight junction-permeability barrier led to BTB tightening, whereas its overexpression using a full-length cDNA construct perturbed the barrier function. These changes were mediated through an alteration on the organization actin microfilaments at the ES in Sertoli cells, involving actin-regulatory proteins, epidermal growth factor receptor pathway substrate 8, actin-related protein 3, and Scribble, which in turn affected the function of adhesion protein complexes at the ES during the epithelial cycle of spermatogenesis. Using Polyplus in vivo-jetPEI reagent as a transfection medium to silence Vangl2 in the testis in vivo by RNA interference with high efficacy, Vangl2 KD led to changes in F-actin organization at the ES in the epithelium, impeding spermatid and phagosome transport and spermatid polarity, meiosis, and BTB dynamics. For instance, step 19 spermatids remained embedded in the epithelium alongside with step 9 and 10 spermatids in stages IX-X tubules. In summary, the PCP protein Vangl2 is an ES regulator through its effects on actin microfilaments in the testis.
A Messianic Aesthetic: Lily Briscoe's Vision
Authors: Restuccia Frances L.
Published: March 2016

This essay reads To the Lighthouse through the lens of Giorgio Agamben's Pauline conception of messianic time and suggests that we reconsider the genre of modernist novels in light of such a “messianic aesthetic.” Insofar as To the Lighthouse presents chronological time impregnated by apocalyptic time, it reveals a coinciding of chronos and the eschaton to produce “the time of the now.” Rather than compensate for loss (the dominant reading), Virginia Woolf's novel reflects Agamben's conception of time by situating salvation in the place of deterioration or the unsavable, celebrating caducity. Woolf presents a contraction of time, through the pulsating rays of the Lighthouse, that carries time to fulfillment and then falls back into potentiality/impotentiality. Lily's eventual embrace of her painting's inevitable destruction underscores the notion that creation and decreation are salvifically coextensive. On the political level, Lily's artistic vision neutralizes Mr. Ramsay's sovereignty by putting his linear journey to a new, playful use—a pure means without end. Given that Agamben laments the scission in the Western cultural tradition between philosophy and poetry, it seems germane that his theory be fleshed out through poetic art. Agamben reveals messianic temporality and its political effects in Woolf, just as Woolf's poetic prose gives to Agamben's ideas a representational bloom. By offering To the Lighthouse as a paradigm, this essay illustrates how Agamben's work may be used for literary interpretation—a brand-new and exciting area, as his writings have not yet been invoked to interpret literary texts.
Estimating energetics in cetaceans from respiratory frequency: why we need to understand physiology
Authors: Fahlman A. , van der Hoop J. , Moore M. J. , Levine G. , Rocho-Levine J. , Brodsky M.
Published: March 2016

The accurate estimation of field metabolic rates (FMR) in wild animals is a key component of bioenergetic models, and is important for understanding the routine limitations for survival as well as individual responses to disturbances or environmental changes. Several methods have been used to estimate FMR, including accelerometer-derived activity budgets, isotope dilution techniques, and proxies from heart rate. Counting the number of breaths is another method used to assess FMR in cetaceans, which is attractive in its simplicity and the ability to measure respiration frequency from visual cues or data loggers. This method hinges on the assumption that over time a constant tidal volume (VT) and O2 exchange fraction (ΔO2) can be used to predict FMR. To test whether this method of estimating FMR is valid, we measured breath-by-breath tidal volumes and expired O2 levels of bottlenose dolphins, and computed the O2 consumption rate (V̇O2) before and after a pre-determined duration of exercise. The measured V̇O2 was compared with three methods to estimate FMR. Each method to estimate V̇O2 included variable VT and/or ΔO2. Two assumption-based methods overestimated V̇O2 by 216-501%. Once the temporal changes in cardio-respiratory physiology, such as variation in VT and ΔO2, were taken into account, pre-exercise resting V̇O2 was predicted to within 2%, and post-exercise V̇O2 was overestimated by 12%. Our data show that a better understanding of cardiorespiratory physiology significantly improves the ability to estimate metabolic rate from respiratory frequency, and further emphasizes the importance of eco-physiology for conservation management efforts.
Current Approaches on Forming the Assessment Tools Stock for Basic University Curricula
Authors: ��������  , Naumenko O. , ������  , Chandra M.
Published: March 2016

The paper presents the experience of the Volgograd State Pedagogical University in elaborating the assessment tools stock for the basic university

educational programs for the current, midterm and end-of-course assessment. The role of disciplinary and interdisciplinary assessment toolkits in the

structure of the basic university curriculum is defi ned. Also suggested is the author�s vision on how the assessment toolkits should be structured and

also the techniques for developing such toolkits. Based on the specifi c examples, the authors show some possible approaches to assessing the level of

students� competences formedness in the course of the current, midterm and end-of course certifying in the higher school institutions. The features,

indicating various levels of competencies formedness are described. The technology for development of the End-of-Course Assessment Program is

presented. The paper is focused mainly on the new approaches to selecting appropriate assessment tools for the state exam. Potential problems, arising

while developing the assessment tools for the end-of-term exam on the �Education and Pedagogy� training program are identifi ed. Also presented are

the examples of practice-oriented assignments, allowing, on the authors� opinion, to identify the level of formedness of the professionally signifi cant

competences.
Innovations in the Pedagogical Process of Higher Education Institution
Authors: �������  , Shamshina I.
Published: March 2016

The main innovative directions in the system of higher education are considered. Analyzed are the innovative models and technologies of training. Also

characterized is the modular system of training as kind of innovation. The main feature of the modular training is systematic: system maintenance; alternation

of informative and educational and professional parts of the module; systemic control. As a result, signifi cantly improved the quality of training

of future specialists in terms of formation and development of an eff ective system of his knowledge and skills in a holistic individualized approach to

the student´s personality, creating the conditions for its independence, the formation of the teacher an atmosphere conducive to improving students´

motivation.

Cognitive activity of a student does not just happen, it is the result of the content and teaching methods - active, intensive and problematic. But it is also

important to create such psychological and pedagogical conditions in which a student can take an active personal position and to fully manifest himself

as the subject of learning activities.
On Culture-General Training of Master�s Degree Students at Higher Pedagogical Institutions
Authors: ���������  , Elkanova B.
Published: March 2016

The ongoing reforms of the Russia�s educational system call for improvements in the system of higher education. Thus there is a critical need to provide the

theoretical and methodological basis for training Master�s degree students, and particularly for the culture-general training. Meanwhile the Federal State

Educational Standard of the 3rd generation does not describe in detail the concept of culture-general training of Master�s students, providing only the set

of general cultural competencies, which students are required to develop to graduate with the Master�s degree. As higher education institutions are free to

set up their own mechanisms of culture-general training, the author emphasizes, that she and her colleagues place a particular focus on culture-general

training of Master�s degree students attending the higher pedagogical institutions, because the graduates would not become valued society members,

unless they have mastered and enhanced the whole range of culture-general competencies.
The �Vital Activity Security and Disaster Medicine� Course in the Light of the New Educational Standards Requirements
Authors: �������  , Malezhik M. , ��������  , Stepanov A. , �����  , Lyubin A. , �����������  , Perepelitsyn N.
Published: March 2016

The paper provides practical experience on teaching the �Vital Activity Secure Safety� course at the Department of Vital Activity Secure and Disaster Medicine

of Chita State Medical Academy in accordance with the requirements, stipulated by the Federal State Educational Standard of the 3rd generation

(FGOS-3). Pressing aspects of teaching and professional skills are considered; the teaching course content, new educational technologies and innovative

teaching techniques are analyzed. Within the Academy�s Practical Skills Center and the simulation class at Transbaikalia Regional Disaster Medicine

Centre the correspondent classes are conducted, using dummies and phantoms. As one of the interactive teaching method the role play on the discipline

concerned has been successfully pioneered. Also the paper features the role of special tactical training exercises and research work, conducted by students,

as necessary to help them to master the required professional competencies.
On Reorganizing the Educational Process at the Clinical Department of Higher Education Medical Institution with Respect to Transition to the Federal State Educational Standard of Higher Education
Authors: ��������  , Sorokina A. , ������  , Bogdan A. , ����������  , Barbukhatti K.
Published: March 2016

The paper considers, how to adapt requirements of the Federal State Educational Standard of the 3rd generation to the educational process, conducted

at the clinical Department of Cardiovascular surgery and cardiology, the Faculty of Professional Development and Re-Training, SBEI of HPE �Kuban

State Medical University�. The issue of training operating cardiovascular surgeons under the conditions, when approaches to training and teaching

at the higher school have changed is considered. The authors suggest the option of learning and teaching support for the educational activities of a

Department, which are in tune with the new requirements and conducive to training the knowledgeable clinicians. Special emphasis is put on the process

of developing culture-general competencies of meta-subject and creative nature in resident medical practitioners. Considered is the idea of critical and

creative application of the construct, already at hand in the pedagogical theory and international practice and helpful for assessing the level of personal

culture-general development of a to-be-professional.
Potential of Extracurricular Activities for Adapting Primary School Students to Studies
Authors: �������  , Ivanova Irina
Published: March 2016

The paper considers how to adapt primary school students to studies as the new for them kind of activity by means of extracurricular activities, as the latter have got the particular role in upbringing and development of children in the course of implementing the Federal State Educational Standard (FGOS). The paper also describes the author�s �New World in My View� program of extracurricular activities with socio-pedagogical orientation, given, that this program is being realized within secondary schools of Kaluga and Kaluga region in terms of working with school-age children. The novelty of the program is outlined along with its structure, content units, methodological support and performance criteria. The program is accompanied with the monitoring system, set up based on the requirements of the RF Government Decree �On implementation of the monitoring system of education� and the requirements to outcomes of mastering the basic educational program of primary education. The �New World in My View� program can be widely applied in the regional educational practice with regard to organizing extracurricular activities of primary school students to help them to successfully master the Federal State Educational Standard of Primary General Education.
Hierarchy and Its Discontents: Status Disagreement Leads to Withdrawal of Contribution and Lower Group Performance
Authors: Kilduff Gavin J. , Willer Robb , Anderson Cameron
Published: March 2016

Research on status and group productivity has highlighted that status hierarchies tend to emerge quickly and encourage contributions to group efforts by rewarding contributors with enhanced status. This and other status research has tended to assume that status hierarchies are agreed-upon among group members. Here, we build on recent work on status conflict in investigating the prevalence and consequences of situations in which group members hold differing perceptions of the status ordering—that is, of who ranks where—which we call status disagreement. Across two studies of interacting groups, we examined several different types of status disagreement and found that disagreements in which two group members both viewed themselves as higher in status than the other, or upward disagreements, were uniquely harmful for groups. These types of disagreements led the involved members to reduce their contributions to the group, substantially decreasing group performance. However, other forms of dyadic status disagreements, as well as overall levels of status consensus, did not significantly affect group functioning. Furthermore, we found that individuals higher in personality dominance were those most likely to be involved in these harmful upward disagreements. These findings demonstrate the importance of more thoroughly considering status disagreement as a dimension that can vary in quantity and type across groups. In doing so, they contribute to understanding of status dynamics and group performance and suggest important implications for teams within organizations.
Opinion
Authors: Denton Phil
Published: March 2016

Everyone, quite rightly, is talking about the importance of student and staff mental health – but our drive to continually raise academic standards is putting good mental health in danger, says Phil Denton
Evaluating the Teaching School project
Authors: Henshaw Pete
Published: March 2016

The national network of Teaching Schools has improved the sharing of good practice, according to new research. However, we cannot yet say what the impact has been on pupils' outcomes. Pete Henshaw reports
Evaluating our CPD
Authors: Weston David
Published: March 2016

How can we build effective evaluation of impact into our professional development? David Weston advises
Technical power and human impotence
Authors: Vanderburg Willem H.
Published: March 2016

The article presents an overview of a five-volume study of the transition of our civilization from a primary reliance on approaches to human knowing and doing based on symbolization and culture to a primary reliance on approaches organizing this knowing and doing by means of disciplines, which has taken us well beyond rationality and technique as a result of desymbolization. It is undermining our being a symbolic species by reifying human lives and communities while creating ways of life that cannot be sustained by the biosphere. These developments have significantly affected the roles of the old and new media in our lives.
Questions concerning Ge-Stell: Heideggerian confrontations with technology
Authors: Gilchrist Brian
Published: March 2016

Martin Heidegger (1889–1976) gained a reputation as one of the most significant and perhaps infamous continental philosophers of the twentieth century. This article addresses the following question: how did Heidegger’s confrontations with ge-stell articulate an approach for contemporary human beings to resist technological domination? Ge-Stell refers to Heidegger’s term for the essence of technology. The essence of technology represents the presupposition that technology provides a means for human beings to dominate nature and to establish a system for ordering the world according to perspectives driven by technology. First, ge-stell is noted as Heidegger’s term that described the essence of technology. Ge-Stell functioned as a paradigm in which human beings accepted technology as the source for answers to all questions and for solutions to all problems about existence. Second, Heidegger’s embrace of Nazism is interpreted as his first attempt to confront ge-stell and to enact a metaphysical revolution in Germany. Third, thinking poetically is positioned as Heidegger’s most successful way for human beings to resist technological domination. Heidegger’s call to thinking represents a bottom-up approach to enact social change that empowers each person to resist ge-stell on an individual basis.
The body electric in the age of virtual reality and transhumanism: Forces changing the West’s notions of self, identity and humanness
Authors: Scott Robert B.
Published: March 2016

This article begins by exploring the relationships connecting Walt Whitman’s ‘body electric’, Marshall McLuhan’s ‘discarnate man [sic]’ and Neil Postman’s ‘citizen of technopoly’. It then examines the disruptive effects that electric technologies have had on western culture’s notions of ‘self’, ‘identity’ and particularly ‘the body’, especially the development of Virtual Reality systems, social networking and transhuman technologies over the past three decades. A survey of new wearable and immersive devices, advances in artificial intelligence, and invasive biotechnical procedures reveals increasingly questionable attempts to replace the human body by machines. These endeavours are supported, notably, by some of the world’s wealthiest investors in artificial intelligence and biotechnology, statesmen, media barons and members of the military – the forces of technopoly. The article concludes that, despite the efforts to replicate, improve or even replace it, the body is essential to our humanness.
Postman’s loving resistance fighter and Ellul’s Christian anarchy as counters to technopoly
Authors: Grosswiler Paul
Published: March 2016

Neil Postman and Jacques Ellul both critiqued a media culture dominated by technique, or technology, although each had a different name for it. Postman called it ‘technopoly’; Ellul called it ‘technological society’ long before. As different as the names were their proposed stances to combat it. Postman wrote fleetingly of the ‘loving resistance fighter’, Ellul of the ‘Christian anarchist’. The former was a more individualized, education-based response, the latter a political, activist response. This article compares their responses and offers a synthesis of the two, ‘the media ecology education anarchist’ in an attempt to mesh the strengths of each approach.
Reviews
Authors: Rose Phil , Lunceford Brett , Logan Robert K.
Published: March 2016

Neuroscience and Media: New Un derstandings and Representations, Michael Grabowski (2015) New York: Routledge, 241 pp., ISBN: 9781138811508, h/bk; ISBN: 9781315749235, e-book, $145.00

Coding Freedom: The Ethics and Aesthetics of Hacking, E. G. Coleman (2013) Princeton, NJ: Princeton University Press, 272 pp., ISBN: 9780691144610, Paperback, $27.95

Marshall McLuhan and Northrup Frye: Apocalypse and Alchemy, B. W. Powe (2014) Toronto: University of Toronto Press, 368 pp., Paperback, $32.95
Kajian Transportasi Sungai Untuk Menghidupkan Kawasan Tepian Sungai Kahayan Kota Palangkaraya
Authors: Hamidah Noor , Rijanta R , Setiawan Bakti , Marfai Muh Aris
Published: March 2016

River is a first transportation for connection city to village and central for economic community. Nowadays, land transportation is a trend  for connection city to village. River transportation have been not priority, due to land transportation more easy to access, low cost and faster rather than river transportation. River have been not priority for infrastructure and river is a backward. River is facing serious problems such as physical and environmental problem. River are still occupy for lower income people as a reason house can built by themselves and close to work location with a location in green belt area. Thispaper try to arguehow is a problem in  river transportation. The location of this research is Kahayan River, Palangkaraya City. This research aim is to reveal of potential of river transportation and unique of moda transportation will be revitalize of Kahayan riverside area of Palangkaraya City, Central Kalimantan.River is a first transportation for connection city to village and central for economic community. Nowadays, land transportation is a trend  for connection city to village. River transportation have been not priority, due to land transportation more easy to access, low cost and faster rather than river transportation. River have been not priority for infrastructure and river is a backward. River is facing serious problems such as physical and environmental problem. River are still occupy for lower income people as a reason house can built by themselves and close to work location with a location in green belt area. Thispaper try to arguehow is a problem in  river transportation. The location of this research is Kahayan River, Palangkaraya City. This research aim is to reveal of potential of river transportation and unique of moda transportation will be revitalize of Kahayan riverside area of Palangkaraya City, Central Kalimantan.
Interpretasi Elemen Vernakular pada Tata Ruang Kawasan sebagai Implementasi Regionalisme Kritis
Authors: Maulana Sherlly , Suswati S
Published: March 2016

Dampak globalisasi di Kawasan Danau Toba telah menyebabkan hilangnya identitas kawasan yang telah mengakibatkan penurunan nilai dan image kawasan. Tujuan penelitian ini adalah menjadikan elemen vernakular sebagai identitas pada tata ruang kawasan, melalui penerapan teori regionalisme kritis. Lokasi penelitian berada di Desa Tongging, Kecamatan Merek, Kabupaten Karo. Tahapan penelitian terdiri dari pengumpulan data melalui arsip literatur tentang vernakular Batak Toba dan survey aktivitas masyarakat Tongging melalui observasi, penyebaran kuesioner, dan wawancara semi-terstruktur, tahap analisis dan sintesis berupa analisis deskriptif kualitatif. Hasil penelitian berupa potensi kawasan yang dapat dikembangkan sebagai identitas kawasan berdasarkan interpretasi elemen vernakular, yaitu: 1) budaya agraris; 2) penataan ruang yang mengadopsi bentuk kampung; 3) budaya gotong royong melalui peningkatan partisipasi aktif masyarakat dalam perbaikan kawasan; dan 4) bentuk arsitektur tropis yang beradaptasi terhadap iklim.Dampak globalisasi di Kawasan Danau Toba telah menyebabkan hilangnya identitas kawasan yang telah mengakibatkan penurunan nilai dan image kawasan. Tujuan penelitian ini adalah menjadikan elemen vernakular sebagai identitas pada tata ruang kawasan, melalui penerapan teori regionalisme kritis. Lokasi penelitian berada di Desa Tongging, Kecamatan Merek, Kabupaten Karo. Tahapan penelitian terdiri dari pengumpulan data melalui arsip literatur tentang vernakular Batak Toba dan survey aktivitas masyarakat Tongging melalui observasi, penyebaran kuesioner, dan wawancara semi-terstruktur, tahap analisis dan sintesis berupa analisis deskriptif kualitatif. Hasil penelitian berupa potensi kawasan yang dapat dikembangkan sebagai identitas kawasan berdasarkan interpretasi elemen vernakular, yaitu: 1) budaya agraris; 2) penataan ruang yang mengadopsi bentuk kampung; 3) budaya gotong royong melalui peningkatan partisipasi aktif masyarakat dalam perbaikan kawasan; dan 4) bentuk arsitektur tropis yang beradaptasi terhadap iklim.