bluuebunny/crossref_metadata_2025 huggingface dataset:
Intra-articular Corticosteroid Injection for Adhesive Capsulitis: A Randomized Controlled Trial
Authors: Chan Julie , Tucker Allison , Hiscox Christina , Fenton Paul , Bicknell Ryan T
Published: September 2024

Background

Adhesive capsulitis is a common cause of glenohumeral joint pain and stiffness that significantly interferes with patients' lives and ability to work. Since no specific treatment options have been well established, this research examines arthrographic injection of the glenohumeral joint with steroid and local anesthetic versus local anesthetic alone for the treatment of adhesive capsulitis.

Methods

A double-blinded randomized controlled trial was conducted with patients diagnosed with idiopathic adhesive capsulitis. They were randomized to one of two groups: (1)local anesthetic plus steroid or (2)local anesthetic. A musculoskeletal radiologist performed all of the image-guided injections using a standardized patient-blinded technique. Outcome measures included shoulder range of motion, grip strength, and scores on the Shoulder Pain and Disability Index (SPADI), Constant Score, and Visual Analog Scale (VAS) for pain. Evaluations occurred at baseline and 3-, 6- and 12-weeks post-injection.

Results

Thirty-seven patients were enrolled in the study. There was no significant improvement in shoulder range of motion and grip strength with local anesthetic plus corticosteroid injection compared to local anesthetic alone. Shoulder range of motion was better at all time points for the group with local anesthetic alone. Both groups showed significant improvements in their VAS and SPADI pain scores at all post-injection follow-up appointments (p=.011). The SPADI results showed significantly better disability scores for the local anesthetic plus steroid group (p=.012) and improved pain scores from baseline at all follow-up times (p=.011), whereas the local anesthetic group had significant pain relief for only the first 3 weeks (p=.050).

Conclusion

Intra-articular injection with local anesthetic plus steroid was beneficial in improving pain but not range of motion when compared to injection with local anesthetic alone.
The Influence of Some Environmental Factors on Temporary Degradation of Organic Components of Paper Pulp and Writing Compositions
Authors: Mehrabova M.A. , Gulmemmedov K. J. , Kochemirovskaya S.V. , Kozhakhmetov S.K. , Barova V.O. , Mokhorov D.D. , Kochemirovsky V.A.
Published: September 2024

Paper sheet materials and written compositions are complex multi-component mixtures,
including dyes, solvents and resins, preservatives, and antioxidants, i.e., complex organic mixtures
that change over time. Technical examination of materials and documents is in demand in the judicial
and archival industry. Determining the actual date of appearance of a particular inscription on a
sheet of paper is one of the most important and complex expert tasks. The task is divided into two
components: analysis of the processes of temporary degradation of paper pulp and processes of temporary
degradation of organic writing materials.
Carnosic Acid and its Pharmacological Activities: An Updated Review
Authors: Bhadouria Vikash Singh , Kharbanda Jyotsna , Verma Sushma , Kumar Arvind , Singh Sachin Kumar
Published: September 2024

Carnosic acid (CA), a polyphenolic diterpene naturally found in Rosmarinus officinalis,
has demonstrated a wide range of pharmacological activities according to scientific research, making
it a key candidate for new therapeutic product development. The aim of this manuscript is to present
an updated review of the literature on the latest research findings about carnosic acid, emphasizing
its most relevant biological functions. Accordingly, this work highlights the main reported pharmacological
activities, such as antioxidant, antidiabetic, anti-inflammatory, antimicrobial, antiobesity,
anticancer, and neuroprotective properties. We conducted a systematic search of bibliographic databases
for peer-reviewed literature based on a specific review question, utilizing scientific databases
including PubMed, Scopus, Science Direct, and Google Scholar published since 1990. Numerous
studies have highlighted the extensive therapeutic applications of carnosic acid. Among others, carnosic
acid was found to have antioxidant, antidiabetic, anti-inflammatory, antimicrobial, antiobesity,
anticancer, and neuroprotective activities. Further, carnosic acid displayed low toxicity levels and
few side effects. CA shows great promise as a therapeutic agent in the prevention and treatment of
many diseases, such as numerous cancers, infectious diseases, and newly emerging illnesses like
Alzheimer’s and Parkinson’s diseases. In recent times, there has been a significant push to improve
PBMs, proposing their application as natural drugs for several pathological conditions, with a focus
on their anti-inflammatory and antioxidant capabilities. Carnosic acid exhibits antidiabetic, antimicrobial,
antiobesity, and neuroprotective effects, as well as antitumor, anti-infectious, CNS, and endocrine
system activities. However, further research on its precise pharmacological mechanisms is
required before it can be reliably used to treat human diseases.
Phytochemical Screening of Genus Primula Species Growing in Georgia and Study of their Antioxidant and Anti-inflammatory Potentials
Authors: Sukhishvili Nino , Franck Thierry , Mouithys-Mickalad Ange , Frederich Michel , Mulkijanyan Karen , Sandersen Charlotte , Serteyn Didier , Mskhiladze Lasha
Published: September 2024

Background:

In traditional medicine, species of the genus Primula L. are used to treat
various health conditions, such as eye disorders, respiratory infections, headaches, epilepsy, insomnia,
as expectorants, and to promote wound healing.

Objective:

The goal of this article was to evaluate the antioxidant and anti-inflammatory activities of
three species from genus Primula L. growing in Georgia: Primula macrocalyx, Primula woronowii
and Primula saguramica.

Methods:

Initially, fractions containing both aerial and underground parts were air-dried, ground,
and extracted with 80% ethanol. The extract was then concentrated by condensation and further dried
through freeze-drying. Subsequently, additional chromatographic separations were carried out on
Diaion HP-20 using solvents such as water, methanol (50% and 100%), and 100% ethyl acetate to
isolate the desired fractions. To identify flavonoids and triterpene glycosides, the study employed
thin-layer chromatography (TLC) alongside preliminary phytochemical tests. The antioxidant activity
of these species was estimated in vitro by cell-free systems using ABTS and DPPH assays. The
extracts' anti-inflammatory properties were evaluated using an ex-vivo cell system that isolated neutrophils.
The study examined the extracts' impact on reactive oxygen species (ROS) production in
neutrophils stimulated with PMA, as well as their effect on the catalytic activity of myeloperoxidase
(MPO), a marker of inflammation in neutrophils.

Results:

Flavonoids and triterpene glycosides were primarily identified in the 50% and 100% methanol
(MeOH) fractions of Primula species through TLC and preliminary phytochemical tests. For each
experiment, gallic acid and quercetin served as standards at a concentration of 1 mg/ml, while the
tested samples were prepared at concentrations of 5 mg/ml. Based on the IC50 findings, P. w 3 exhibits
the most potent antioxidant and anti-inflammatory properties, as evidenced by the following
indicators: ABTS - IC50=8.51 ± 0.18; DPPH - IC50=34.57 ± 0.47; PMN - IC50=0.68 ± 0.04; SIEFED
- IC50=1.49 ± 0.7; and classical IC50=1.89 ± 0.01.

Conclusion:

Among the tested fractions, only the fraction of the 3 species prepared in MeOH (50%)
showed the best dose-dependent antioxidant and anti-inflammatory activities, especially P.w 3 which
is probably related to the high flavonoid content found in this species.
Clinical Application of Traditional Chinese Medicine in Pneumonia Complicated with Heart Failure Based on Data Mining Algorithms
Authors: Yang Rongyuan , Deng Qingping , Zeng Xing , Cai Huayang , Liu Qing
Published: September 2024

Objective:

This study aimed to investigate and analyze the existing literature regarding
the clinical utilization of Traditional Chinese Medicine (TCM) in cases of pneumonia complicated
by heart failure by employing data mining algorithms.

Methods:

The study gathered medical cases of treating pneumonia complicated with heart failure
from CNKI, Wanfang, VIP, and PubMed databases without imposing any temporal restrictions.
We extracted medication details and built a comprehensive database in Microsoft Excel 2019.
The analysis included frequency, cluster, and complex network analyses, along with association
rule visualization. These analytical procedures were executed using specialized software, such as
SPSS Statistics 26.0, SPSS Modeler 18.0, and Gephi.

Result:

This study included 47 articles meeting specific criteria, with 53 prescriptions and 110
different drugs. Pathological patterns observed included heart-yang deficiency, lung obstruction
by phlegm-heat, qi-yin deficiency, and internal closure with external prolapse. Medications fell
into categories like tonics, antitussives, heat-clearing, and wind-dispersing drugs, with cold,
warm, and neutral properties most common. Bitter, sweet, and pungent tastes were predominant.
Many drugs were found to target specific meridians like the lung, stomach, spleen, and heart.
Cluster analysis grouped 40 frequently used drugs into 6 categories, revealing complex relationships.
Network analysis identified core drugs for treating pneumonia complicated with heart
failure, emphasizing their importance in managing this complex medical condition.

Conclusion:

Key Chinese herbal medicines for pneumonia complicated with heart failure include
Ophiopogon japonicus, liquorice root, red ginseng, Ansu apricot seed, ginseng root, pepperweed
seed, and Chinese ephedra herb. They focus on promoting lung Qi, strengthening Qi
and blood, and improving blood circulation to address stasis. This data supports future clinical
research in managing pneumonia and heart failure.
A Comprehensive Review on Power Management Topologies in Renewable Energy
Authors: Raj Nandita , Yadav Mukh Raj , Singh Mayank , Singh Navdeep
Published: September 2024

In hybrid renewable energy systems, it consists of various sources with their properties
for power management is an essential responsibility. To maintain the system's dependability, stability,
and efficiency, the power management strategy attempts to balance the power flow between
the sources, load, and energy storage system. With an emphasis on the effects of source variation
on system performance, the author examines different power management techniques for hybrid
renewable energy systems that have been put out in the literature. In this paper, the author divides
the strategies into four groups as intelligent, rule-based, filtration-based, and optimization-based.
To demonstrate the benefits and drawbacks of each category, as well as the difficulties and potential
paths forward for power management in the face of source fluctuation.
Overview on Nanomaterials for Nanocosmetics
Authors: Nikharge Sushmita , Jadhav Kisan R. , Sanap Dhanashree
Published: September 2024

One of the scientific areas with the highest growth right now is nanotechnology. The development
of nanocosmetics through the use of nanoscale materials has become more popular in recent
years. Due to distinct structures, chemical, physical, physiochemical, and functional properties -
most of them are absent in their non-nanoscale forms - some nanomaterial types are extremely appealing
for use in the cosmetics sector. Regardless of their kind, form, morphology, or content, nanomaterials
have two primary purposes in cosmeceutical inventory [1]: nano-constructs as (UV) filters,
and [2] nanostructures as biologically active components for topical applications and other treatments
associated with cosmeceuticals, such as moisturizers, skincare, makeup, sunscreen, and hair care products.
As Ultraviolet filters or Ultraviolet protectants, various types of nanoparticles, such as silver,
gold, titanium, and zinc, have been employed in the former scenario to hinder or to Utilize UV radiation
and shield the layer beneath the skin from damaging consequences. Nanoliposomes are the delivery
systems used in the 2nd concept usage. Therefore, next-generation cosmeceutical solutions for
blossoming beauty that offer enhanced skin hydration, bioavailability, agent stability, and regulated
UV occlusion have been highlighted as potentially becoming nanomaterial-loaded nanocosmetics. In
light of the criticisms mentioned earlier and the potentialities of nanomaterials, we first examined the
benefits of using nanoliposomes and nanoparticles as UV filters and delivery systems. The work's
second split discusses the safety and legal implications of nanoparticles employed in compositions.
Concluding remarks and suggestions for further study round out the work and enable material scientists
to securely utilize nanoparticles in large-scale commercial goods.
Utilization of Plant based Nanoparticles Emerging in Nano-biomedical Science to Target Drug Deliveries for Breast Cancer Treatment: Existing
Work and Future Need
Authors: Munir Saba , Nawaz Yasir , Parveen Sara , Sadiqa Ayesha , Rehman Samiya , Riaz Hafiza Fizzah , Tanvir Fouzia , Saira  , Nawaz Aqeela , Naz Misbah , Nawaz Basit
Published: September 2024

Cancer is a major global health concern and a hereditary disease brought on by alterations
in the genetic code that controls how cells behave. In the United States and other countries,
breast cancer is very common among females. Through the development of innovative biocompatible
Nanocomposites for therapy, which demonstrate a highly appropriate manner of nanoparticles,
Nanomedicine offers incredible potential to develop cancer treatment and diagnosis. More than
60% of anticancer medications on the market today are derived from natural sources. Historically,
plants have been used to treat a wide range of illnesses, including cancer. This work aimed to treat
breast cancer with plant-based nanoparticles. The information was gathered from research that has
already been published on Google Scholar, PubMed, and Web of Science. Different nanoparticles
have been shown to be effective drug delivery agents to treat breast cancer. These include gold, silver,
platinum, iron, zinc oxide, copper nanoparticles, and other metals, such as nickel, manganese,
silica, titanium, palladium, cerium, and platinum. It was discovered that all metal preparation nanoparticles
have an effective function in the treatment of infectious diseases and cancer. In conclusion,
the characteristics of biomolecules included in plant extracts may be connected to the greenproduced
NPs. Because of their high effectiveness, plant based NPs synthesis will be necessary in
the future to treat breast cancer.
Risk Factors of Age VS Other Comorbidities in Severe COVID-19: An Umbrella Review
Authors: SeyedAlinaghi SeyedAhmad , Mirzapour Pegah , Yarmohammadi Soudabeh , Afsahi Amir Masoud , Ahmadi Sepide , Roozbahani Mohammad Mahdi , Haghi Parnian , Karimi Elaheh , Mohammadi Sina , Tabari Amir , Molla Ayoob , Mehraeen Esmaeil
Published: September 2024

Introduction:

This umbrella review offers a comprehensive analysis of the association
between age and other risk factors in the incidence and severity of COVID-19.

Method:

This umbrella review aims to compare age with other risk factors of COVID-19 infection.
Literature featuring systematic reviews and the English language in electronic databases of PubMed,
Embase, Scopus, and Web of Science was considered for this purpose. Appropriate articles were
selected following two separate steps, and after meeting the inclusion/exclusion criteria, they went
through data extraction. This umbrella review coheres with the PRISMA checklist and the
AMSTAR-2 tool specified for quality assessment.

Result:

A total of 55 articles met the inclusion criteria. For risk factors associated with COVID-19
severity, the most relevant were age and underlying comorbidities, each identified in 45 cases. Obesity
was noted in 12 cases, making it the least prevalent risk factor in the studies. Other factors included
sex, smoking, and conditions during hospitalization.For clinical outcomes, in addition to issues
such as discharge, ICU, death, etc., other issues such as renal and cardiovascular disorders were
observed.

Conclusion:

The collective evidence presented in this review underscores various risk factors associated
with severe COVID-19 outcomes, which can be used to update clinical management guidelines
and assist in determining patients’ prognoses.
Clinical and Laboratory Factors Associated with Mortality in ICU-Hospitalized COVID-19 Patients in a Western Center of Iran
Authors: Borzouei Shiva , Khazaei Salman , Nouri Reza , Tahmasebi Reza , Talebi-Ghane Elaheh
Published: September 2024

Introduction:

The purpose of this study was to investigate the demographic, clinical, and
laboratory risk factors associated with mortality in Coronavirus disease 2019 (COVID-19) patients
who were admitted to the intensive care unit (ICU) in Iran.

Material & Methods:

This retrospective study analyzed data from 867 COVID-19 patients admitted
to the ICU of Shahid Beheshti Hospital in Hamadan (west of Iran) from September 2020 to March
2022. The association between demographic, clinical, and laboratory factors and mortality rates was
assessed using univariable and multiple logistic regression analysis.

Results:

During the study period, 512 (59.1%) patients were deceased from Covid-19. According to
the adjusted logistic regression, the odds of death in patients with an age higher than 60 years were
1.12 (95% CI: 1.01- 1.24; p=0.026). The OR estimate of death in patients with bradycardia and tachycardia
was 2.32 (95% CI: 1.72- 3.12; p < 0.001) and 2.40 (95% CI: 1.67- 3.42; p < 0.001), respectively.
Moreover, SPO2 lower than 88%, WBC over 11 ×1000μL, K over 5.2 mEq/L, and LDH
above 942 U/L were significantly associated with increased odds of death (p < 0.05).

Conclusion:

The study identified several demographic, clinical, and laboratory risk factors associated
with mortality in COVID-19 patients admitted to the ICU in Iran. These findings can help
healthcare providers identify patients at higher risk of poor outcomes and tailor interventions accordingly.
Rivalitas Hidropolitik: Meninjau Kerjasama di Balik Konflik Sungai Brahmaputra Antara India dan China
Authors:   Universitas Brawijaya, Defianti Digna
Published: September 2024

Competition for water resources is one of the most important problems in the world given the limited availability of clean water sources. Several countries in the world depend on their water supply needs to other countries because they are unable to meet their own clean water needs. Therefore, cooperation in the field of waters is carried out by a number of countries to be able to overcome conflicts that occur due to water problems. As is the case with the conflict between China, Bangladesh and India regarding the Brahmaputra River, the river that crosses these three countries is at the same time very important for the supply of clean water for these three countries. So the formulation of the problem in this paper is "How is the analysis related to the cooperation behind the Brahmaputra River conflict between India and China and the interests behind the cooperation?" and this paper aims to describe the understanding and discussion related to hydropolitic and water diplomacy in the Brahmaputra River conflict and to analyze and examine the interests of cooperation between China and India in resolving the Brahmaputra River conflict. The method used in this study is a qualitative research method where the author uses literature study in data processing. The author uses the concepts of Hydropolitics and Water Diplomacy in the analysis process so that it is found that the Brahmaputra River conflict between China and India is handled by the MoU of Water Cooperation.
Upaya Mediasi Utusan Khusus PBB Lakhdar Brahimi dalam Resolusi Konflik Suriah Tahun 2012-2014
Authors:   Universitas Padjajaran, Indy Razani Rayhan
Published: September 2024

Sejak tahun 2011, Suriah telah dilanda perang saudara terbesar di Timur Tengah. Beberapa upaya mediasi telah dilakukan, terutama oleh Perserikatan Bangsa-Bangsa (PBB), namun sampai saat ini belum ada hasil yang memuaskan. Konflik ini merubah kondisi kehidupan jutaan warga Suriah. Dengan mengangkat resolusi konflik, penelitian ini berusaha untuk menelaah langkah-langkah upaya mediasi yang dilakukan oleh PBB, khususnya oleh Utusan Khusus untuk Suriah Lakhdar Brahimi. Analisis ini ditujukan untuk mengulas dan mengeksplorasi bagaimana langkah-langkah mediasi yang diterapkan oleh PBB dalam berupaya untuk mengatasi konflik di Suriah serta pengaruh eksternal dari negara-negara lain. Penelitian ini menggunakan metode kualitatif dengan 2 jenis sumber data, yaitu penelitian berbasis dokumen resmi dan penelitian berbasis internet. Penelitian ini menemukan bahwa terdapat beberapa langkah yang diterapkan oleh Lakhdar Brahimi yang merugikan Suriah dan gagal dalam mengakhiri perang saudara di Suriah. PBB telah menunjuk dua utusan khusus setelah Lakhdar Brahimi dan satu sebelumnya. Langkah-langkah yang dilakukan sebagian besar sama dan tidak dapat disetujui oleh setiap pihak yang terlibat dalam konflik ini.
Management of Pneumomediastinum Patients in COVID-19: Rare Cases
Authors: Santosa Andrew , Djajalaksana Susanthy , Listyoko Aditya , Erawati Dini
Published: September 2024

Background: Spontaneous pneumomediastinum in patients with confirmed cases of Covid-19 is a very rare clinical finding in the world, especially in Indonesia. This is considered an indication of concern for a more serious medical problem.
Aim: This case report discusses the management of COVID-19 patients with pneumomediastinum.
Case: A 30 year old man came to the hospital with the main complaint of shortness of breath and cough. The patient was diagnosed with a confirmed case of Covid-19 and received therapy using High Flow Nasal Cannula (HFNC) as a therapeutic modality. After 5 days in the hospital, the patient's shortness of breath felt increasingly severe, and he began to feel chest pain and swelling around the chest area which spread to both sides of his neck. A thorax x-ray examination showed pneumomediastinum and subcutaneous emphysema, then a chest CT scan was performed and the results showed pneumomediastinum which was thought to be caused by esophageal rupture. After we communicated with the Thoracic Surgery Department, conservative therapy was recommended.
Conclusion:  Covid-19 infection can cause hypoxaemic respiratory failure and acute respiratory distress syndrome, both of which can be deadly. Supplementation of high-flow nasal cannula (HFNC) oxygen therapy can be very beneficial for patients, but can cause dangerous side effects such as pneumomediastinum. Pneumomediastinum (PM) is the presence of open air in the mediastinal cavity. In this case, we suspect that the pneumomediastinum was the result of Covid-19-related alveolar damage and esophageal rupture, and not due to the use of HFNC. Pneumomediastinum complications need to be detected early, so that management can reduce associated morbidity and mortality.
 
Keywords:  Pneumomediastinum; COVID-19, HFNC
Very Rare Case of Pulmonary Lepidic Adenocarcinoma at a Young Age Man
Authors: Kristy Anastasia , Putra Wayan
Published: September 2024

Introduction: Lung cancer remains one of the higher prevalence of cancer and leading cause of death in the world. Smoking and genetic factors are two important etiologies in lung cancer. Adenocarcinoma is the most common type of non-small cell lung carcinoma. Lepidic predominant adenocarcinoma is one type of adenocarcinoma that has a good prognosis.
Case Illustration: A 24-year-old male came with chronic cough and chest pain. He had a history of smoking and no prior family history of cancer. Plain chest Xray and Thorax computed tomography (CT) showed pleural effusion and presence of lung mass with suggestion of bone and liver involvement, respectively. The cytology from pleural effusion and bronchial lavage initially found no malignancy cell. Later thoracostomy biopsy and pathology study suggested lepidic adenocarcinoma.
Discussion: Lung cancer is still one of the leading causes of death in men. Even though rarely found in young male, patients with a history of smoking or genetic factor with clinical manifestation suggestive chronic respiratory condition with weight loss should be suspected of the diagnosis. Adenocarcinoma, as the most common non-small cell lung carcinoma, could be later divided into several subtypes. Lepidic adenocarcinoma is distinguished by the pathology finding of a large invasion focus of stromal, lymphatic, vascular, or pleural space. Considered one of the most favorable, lepidic predominant adenocarcinoma has a very high rate of 5 year survival when diagnosed early and responds well to lobe resection. Advanced state however has poor outcome due to limited choice of therapy. Promising trial of targeted chemotherapy have been reported and could improve outcome in the future.
Conclusion: Lung cancer in young male is a rare disease but should be suspected in those with chronic cough, chest pain and weight loss. The history of smoking and family history are crucial for this suspicion. Lepidic predominant adenocarcinoma has a good prognosis when diagnosed early. Studies in the future could enhance overall survival in these patients.
A mathematical primer to classical deep learning
Authors: Albert Enow Takang Achuo , Bille Ngalle Hermine , Leonard Ngonkeu Mangaptche Eddy
Published: September 2024

This manuscript synthesizes the statistical foundations of classical deep learning by integrating insights from eight seminal works. It covers matrix calculus, neuron layers, weight and bias indexing, cost functions, differentiation of neuron operations, activation functions, bias functions, gradient descent, and backpropagation algorithms. The synthesis aims to provide a comprehensive understanding of the mathematical and statistical principles underpinning deep learning models, facilitating their application and further development in various domains.
Health Professionals’ Views on the Use of Conversational Agents for Health Care: Qualitative Descriptive Study
Authors: MacNeill A Luke , MacNeill Lillian , Luke Alison , Doucet Shelley
Published: September 2024

Background

In recent years, there has been an increase in the use of conversational agents for health promotion and service delivery. To date, health professionals’ views on the use of this technology have received limited attention in the literature.

Objective

The purpose of this study was to gain a better understanding of how health professionals view the use of conversational agents for health care.

Methods

Physicians, nurses, and regulated mental health professionals were recruited using various web-based methods. Participants were interviewed individually using the Zoom (Zoom Video Communications, Inc) videoconferencing platform. Interview questions focused on the potential benefits and risks of using conversational agents for health care, as well as the best way to integrate conversational agents into the health care system. Interviews were transcribed verbatim and uploaded to NVivo (version 12; QSR International, Inc) for thematic analysis.

Results

A total of 24 health professionals participated in the study (19 women, 5 men; mean age 42.75, SD 10.71 years). Participants said that the use of conversational agents for health care could have certain benefits, such as greater access to care for patients or clients and workload support for health professionals. They also discussed potential drawbacks, such as an added burden on health professionals (eg, program familiarization) and the limited capabilities of these programs. Participants said that conversational agents could be used for routine or basic tasks, such as screening and assessment, providing information and education, and supporting individuals between appointments. They also said that health professionals should have some oversight in terms of the development and implementation of these programs.

Conclusions

The results of this study provide insight into health professionals’ views on the use of conversational agents for health care, particularly in terms of the benefits and drawbacks of these programs and how they should be integrated into the health care system. These collective findings offer useful information and guidance to stakeholders who have an interest in the development and implementation of this technology.
Ayurveda Management of Allergic Rhinitis: Protocol for a Randomized Controlled Trial
Authors: Mata Shweta , Rajput Shivshankar , Tuli Isha Preet , Mundada Pallavi , Gupta Bharti , Srikanth Narayanam , Acharya Rabinarayanan
Published: September 2024

Background

Allergic rhinitis (AR) is the inflammation of the membranes lining the nose due to allergen exposure and is characterized by sneezing, nasal congestion, itching of the nose, or postnasal discharge. The prevalence varies worldwide, perhaps due to the geographic and aeroallergen differences, with 10% to 30% of the world’s population experiencing AR. In this study, Anu Taila Nasya, Naradiya Laxmivilas Rasa, and Shirishadi Kwath will be compared to a fluticasone nasal spray.

Objective

The primary aim is to assess the efficacy of Ayurvedic management for AR (or vataja pratishyaya) by comparing it to a conventional control group. The secondary aims are to determine the mean change in the nasal endoscopy index and the mean change in the laboratory tests.

Methods

This ongoing study is an open-label randomized controlled interventional trial, with a sample size of 90 both in the trial and standard control group (including dropouts, 20%), and will be carried out for 24 months. Participants in the trial group will receive Ayurvedic treatment, that is, Anu Taila Nasya (6 drops in each nostril for 7 days for 3 consecutive weeks), Naradiya Laxmivilas Rasa (250 mg twice per day), and Shirishadi Kwath (40 ml twice per day for 45 days). The participants in the control group will receive a fluticasone propionate nasal spray (2 sprays once per day for 45 days). The primary outcome will include the mean change in the Control of Allergic Rhinitis and Asthma Test score, and the secondary outcomes will include the mean change in the nasal endoscopy index (assessment of nasal membrane color, pale or hyperemia; rhinorrhea, watery or yellow; and inferior turbinate swelling, hypertrophy) and the mean change in the laboratory tests.

Results

As of May 2024, 72 patients have been enrolled in both groups. Data analysis should be completed by February 2025. The study will be reported following standard guidelines for reporting randomized controlled trials. Clinical results will be disseminated through conferences and peer-reviewed publication in a relevant journal.

Conclusions

The Ayurvedic approach could be an evidence-based therapeutic tactic for the management of AR.

Trial Registration

Clinical Trials Registry India CTRI/2023/06/053395; https://tinyurl.com/564d2zz8

International Registered Report Identifier (IRRID)

DERR1-10.2196/56063
The Dilemma of Identifying Copyright Infringement Liability of Network Platform under Algorithm Recommendation Model
Authors: Zhou Ruifei , Xiong Siyi
Published: September 2024

In the digital age, the application of algorithm technology realizes the efficient transformation from “people looking for information” to “information looking for people”, which greatly expands the transmission boundary of articles and video content. However, to some extent, this kind of change also intensifies the problem of copyright infringement on the network platform. Once online copyright works are published, they can be widely disseminated, and it is difficult to remedy the damage suffered by them. The existing laws and regulations have deficiencies in this regulation. This paper starts from the dilemma of network copyright protection under the algorithm recommendation mode, and puts forward some relief measures such as platform filtering obligation based on the actual situation.
Mitigating Complex Cyber Threats: An Integrated Multimodal Deep Learning Framework for Enhanced Security
Authors: Mohan Rathish , Vajpayee Abhishek , Gangarapu Srikanth , Chilukoori Vishnu Vardhan Reddy
Published: September 2024

Abstract: The rapidly evolving landscape of cyber threats poses significant challenges to traditional cybersecurity methods, particularly in detecting and mitigating complex attacks that combine multiple data modalities. This article introduces a novel approach utilizing Multimodal Deep Learning (MDL) to enhance cybersecurity detection and prevention capabilities. By fusing Natural Language Processing (NLP) and computer vision techniques, our proposed MDL framework demonstrates superior performance in analyzing both textual and visual data associated with potential threats. Through a series of experiments and case studies, we show that this integrated approach significantly improves detection accuracy, reduces false positives, and exhibits remarkable adaptability to emerging attack vectors. Our results indicate a 37% increase in threat detection efficiency and a 42% reduction in false positives compared to traditional unimodal methods. Furthermore, we explore the potential applications of this technology in email security, social media monitoring, and advanced malware detection. This article not only contributes to the growing body of knowledge in AI-driven cybersecurity but also provides a roadmap for future developments, including the integration of audio analysis and the application of Explainable AI (XAI) to enhance trust and transparency in MDL-based security systems.
Factors Influencing the Click Intension Towards Mobile App Ads
Authors: Bharadwaj Karthik G
Published: September 2024

With the rapid growth of mobile platforms, in-app advertising has emerged as a key component of modern marketing strategies. Understanding the factors influencing consumers' click intentions toward mobile app ads is critical for optimizing engagement and conversion rates. This study examines various determinants, including ad relevance, user experience, perceived value, privacy concerns, and technology literacy, which collectively shape consumer responses to mobile app ads. While technology literacy plays a role in how users interact with digital content, factors like ad design, user motivation, app environment, and contextual relevance also significantly impact click behavior. By analyzing these variables, this research aims to provide marketers with actionable insights to craft more effective and targeted advertising campaigns. The findings will offer a deeper understanding of the drivers behind click intentions, enabling marketers to enhance user engagement and boost ad performance in the increasingly competitive mobile ecosystem.
Exploring the Role of Labor Welfare Programs in Enhancing Productivity and Performance in Real Estate Business in India
Authors: Tiwari Hemant Kumar
Published: September 2024

ŵम कʞाण कायŊŢम भारतीय įरयल एːेट Ɨेũ मŐमहȕपूणŊभूिमका िनभातेहœ, कमŊचारी उȋादकता, ŮदशŊन, और कु ल भलाई मŐयोगदान देतेहœ। यह पेपर ŵम कʞाण पहलो ं के महȕ की जांच करता है, जो įरयल एːेट उȨोग मŐकमŊचारी बांधन, रखरखाव, और संगठनाȏक Ůभाव पर उनका Ůभाव देखता है। सािहȑ की समीƗा और इन कायŊŢमो ंके Ůभाव को Ůभािवत करने वालेमुƥ कारको ं का िवʶेषण के माȯम से, अȯयन िडज़ाइन और कायŊŢम की कायŊƗमता मŐमानदंड, संचार, और िनयिमत मूʞांकन की महȕपूणŊता को हाइलाइट करता है। संगठनाȏक संˋृ ित मŐŵम कʞाण कायŊŢमो ं का एकीकरण रणनीितक आवʴकता के ŝप मŐŮकट होता है, कमŊचारी बांधन, वफादारी, और संगठनाȏक Ůितʿा को बढ़ावा देता है। इस अनुसंधान मŐपाये गए पįरणाम ŵम कʞाण और संगठनाȏक सफलता के बीच के संबंध को दशाŊतेहœ, कमŊचारी कʞाण को Ůाथिमकता देनेऔर सामािजक िजʃेदारी, पाįरİ̾थितक िटकाऊता, और नैितक नेतृȕ को बढ़ावा देनेकी आवʴकता को जोर देतेहœ। उȨोग-िवशेष आवʴकताओंका समाधान करकेऔर कानूनी मानको ंऔर सामािजक अपेƗाओंके साथ ŵम कʞाण कायŊŢमो ंको संरिचत करके, įरयल एːेट कं पिनयाँदीघŊकािलक िवकास और समृİȠ के िलए एक सकाराȏक कायŊवातावरण बना सकती हœ।
PENGARUH SUBSTITUSI TEPUNG JAGUNG KUNING (Zea mays L.) DAN PUREE WORTEL (Daucus carota L.) TERHADAP KARAKTERISTIK FISIKOKIMIA DAN ORGANOLEPTIK MIE BASAH
Authors: Olivia Dita Rizma , Damat Damat , Manshur Hanif Alamudin
Published: September 2024

Wet noodles are food products made from wheat flour that are not dried. Every year, the production and consumption of noodles in Indonesia is increasing. So, there is a need for food diversification in the raw material by utilizing local food ingredients such as corn flour. The use of carrot puree aims to increase the carotenoid content which acts as a good antioxidant for the body. This research was conducted using a simple Randomized Block  Design (RBD) method. There were 6 treatments and 4 replication, P0 (100% wheat flour), P1 (50% wheat flour: 50% corn flour), P2 (50% wheat flour : 45% corn flour: 5% carrot puree), P3 (50% wheat flour: 40% corn flour: 10% carrot puree), P4 (50% wheat flour: 35% corn flour: 15% carrot puree), P5 (50% wheat flour: 30% corn flour: 20% carrot puree). The best wet noodles were obtained from treatment P5 (50% wheat flour: 30% corn flour: 20% carrot puree) with moisture content of 70.05%, ash content of  0.26%, fat content of  6.94%, protein content of 4.65%, carbohydrates content of 18.08% and carotenoids content of 3.02 mg/100g, brightness 63.5, yield 172.44%, organoleptic color 4.13 (attractive), aroma 3.63 (quite like), taste 3.80 (good), and texture 2.65 (not chewy).
INOVASI PEMBUATAN PRODUK NUGGET ANALOG BERBAHAN DASAR TEMPE DAN JANTUNG PISANG KEPOK SEBAGAI ALTERNATIF SUMBER PROTEIN DAN SERAT
Authors: Agustin Wida Ayunindya , Saati Elfi Anis , Siskawardani Devi Dwi
Published: September 2024

Abstract. Vegan is a lifestyle of someone who does not consume products derived from animal raw materials. Nuggets are food products made from various types of meat, including fish and chicken meat. The disadvantages of chicken nuggets are that they contain high fat and low fiber. Tempeh and banana blossoms were chosen because they have the advantages of high protein content and high fiber. The research design used in this study was a randomized group design consisting of 6 treatments and 3 replications. The added treatment was the proportion of tempeh and kapok banana blossom with the proportions (100%:0%, 90%:10%. 80%:20%, 70%:30%, 60%:40%, and 50%:50% ). The best treatment proportion was P1 with a ratio of 80% tempe: 10% banana flower with 49.11% water content, 0.89% ash content, 19.33% fat content, 4.29% fiber content, 22.50% carbohydrate content , and protein content 9.05%, organoleptic color 5.72 (bright), aroma 4.64% (fragrant), 4.04 (tasty), texture 4.20 (a bit soft) and preference (like).
Keywords: nuggets, kepok banana heart, tempeh, protein, fiber
IDENTIDAD URBANA Y MEMORIA LA CALLE DEL COLORADO Y PARQUE DE SANTIAGO EN LA CIUDAD DE PASTO COLOMBIA
Authors: Salas Salazar Vicente Fernando , Figueroa Estrella Jorge Adrian
Published: September 2024

El presente artículo basado en el trabajo de investigación titulado “Procesos Identitarios Urbanos en la Población del Sector del Parque Santiago y la Calle del Colorado de la Ciudad de Pasto Nariño”, tiene como objetivo principal identificar las características históricas y ahistóricas del sector de la calle del Colorado en la ciudad de Pasto, Colombia. Se aborda la pérdida de identidad de los residentes a medida que las costumbres y tradiciones se han adaptado a la dinámica de la ciudad, generando transformaciones en su identidad.
La investigación se enmarca en el paradigma sociocultural con énfasis en el enfoque cualitativo, lo que permite comprender las expresiones de los actores sociales, sus vivencias y experiencias en sus contextos sociales y culturales para la reconstrucción histórica. Se busca identificar los procesos identitarios urbanos del sector del parque Santiago y la calle del Colorado de la ciudad de Pasto, con el fin de corroborar la identidad cultural y los valores de dicho sector. Para ello, se plantea identificar los antecedentes de los hechos sucedidos en los sectores del Colorado y Santiago de la ciudad, determinar el conjunto de prácticas, expresiones culturales, sociales y políticas que han incidido en la construcción identitária de los habitantes de la calle del Colorado, y analizar los resultados obtenidos con relación a sus apreciaciones.
La observación de segundo orden y su relación con la historia cultural: una aproximación metodológica
Authors: Pabón Erazo John Jairo
Published: September 2024

El presente artículo tiene por objetivo brindar un acercamiento a la observación de segundo orden como una herramienta metodológica dentro de la historia cultural. El texto surge a partir de una revisión bibliográfica y de la reflexión teórica y metodológica entre la historia cultural y la observación del segundo orden. Por consiguiente, se busca abrir perspectivas metodológicas que ayuden a comprender a la historia como un sistema de comunicación en general y a la historia cultural como una observación de la realidad en particular.
Modification of the method of hierarchy analysis based on the elimination of the subjectivity of expert assessments using the example of choosing a rational option for a belt conveyor drive system
Authors:   Academician I.G. Petrovskii Bryansk State University, Goncharov K.A.
Published: September 2024

The expert assessment method underlies most decision-making methods in the technical field of activity, from the search for rational design solutions to issues of industrial safety of hazardous production facilities, which is embodied in the form of regulatory documents governing the implementation of a risk-oriented approach to problem solving in the specified areas. The subjectivity of the expert assessment method can often lead to decisions that are objectively not rational in a specific design situation. This article considers a modification of the superstructure of the criteria weight assessment level of the hierarchy analysis method based on statistical processing of a set of possible combinations of criteria priorities using the example of choosing a rational option for a belt conveyor drive system, which is a direct replacement for the expert assessment method and paired comparisons at this hierarchy level. It is shown that when taking into account the proposed modification and paired comparison at the first level of the hierarchy of clearly defined values of options within each criterion (characteristics of technical objects), the method of paired comparisons is excluded from the structure of the methodological apparatus of the hierarchy analysis method, which makes it possible to single out the obtained set of results into a separate decision-making method.
Kinematic analysis, methods and experimental studies of robot navigator movements on mecanum wheels
Authors:   Russian University of Transport, Sladkova L.A. , Pshibiev A.M. ,   Russian University of Transport
Published: September 2024

Machine learning and artificial intelligence, capable of making decisions on their own, have become indispensable tools for optimizing warehouse operations. The use of lifting equipment on a mobile platform on mechanical wheels in warehouses has a high degree of practical implementation, since the platform in question can move in any direction without U-turns. Kinematic studies of the movement of the robotic arm on the platform under consideration make it possible to opti-mize its movement and behavior in conditions of movement in a confined space with movable and fixed obstacles, which, from the standpoint of creating a mathematical model of platform control, are input parameters that determine the operating conditions of the platform. The methodology for conducting experimental studies and their analysis allow you to optimize the management and behavior of the platform in practice. The platform movement algorithm is developed taking into account its features and is designed to select the optimal route and navigation accuracy under changing space conditions (moving and stationary objects). In order to verify and evaluate the effectiveness of the localization and path planning algorithm in order to improve the control system of the mobile platform on mecanum wheels, modeling and simulation of the presented model were carried out, which made it possible to assess the kinematic parameters of the platform to achieve better results. The kinematic analysis made it possible to carry out a qualitative and quantitative assessment of the features of the movement of the platform behavior in space with various input data. Modeling and simulation of the path localization and planning algorithm made it possible to test its effectiveness in various operating conditions. The studies carried out have shown that the proposed method of kinematic analysis of the navigation system of a warehouse robot on mecanum wheels allows you to optimize its operation in warehouse conditions, which will increase the efficiency of cargo movement and ensure accurate navigation in the limited space of the warehouse. The development of kinematic and dynamic analysis of the navigation system of a warehouse robot on mecanum wheels opens up prospects for the creation of intelligent and autonomous solutions in the field of logistics and warehousing.
Classification of failures and malfunctions of passenger cars with the aim of creating a technical condition assessment system
Authors:   Russian University of Transport, Tarichko V.I. , Ratnikov R.A. ,   Russian University of Transport
Published: September 2024

The article provides an overview and classification of motor vehicle faults (class: passenger cars). The cause-and-effect relationships «Fault-RTA» are studied. Failure of steering and suspension elements entails loss of vehicle control, which leads to traffic accidents. It is determined that safety is significantly affected and cannot be self-diagnosed by articulated joints of ball joints and stabilizer struts. The ball joint is the support of the hub. Failure of the ball joint leads to loss of control of the vehicle’s trajectory due to the fact that the wheel occupies an arbitrary and uncontrolled position in the wheel arch. Wear of the ball joint consists in the occurrence of play in the joint, which is now diagnosed by human senses. The technical condition is assessed using a primitive method: the vehicle is suspended and, using a lever, the mechanic applies various loads to the ball joint. The article predicts the possibility of creating a self-diagnostic system for joints with articulated joints. Along with this, a statistical analysis of emerging failures and malfunctions in cars by brand and class is carried out, which allows us to assert the constancy of the problem under study. An analysis of the relationship between failures and malfunctions with road accidents is carried out, which reflects the most frequent causes of accidents due to vehicle malfunctions.
SCIENTIFIC TOURISM: STATUS AND PROBLEMS OF DEVELOPMENT
Authors:   Vologda Scientific Center of the Russian Academy of Sciences, Bezgacheva Anastasia , Zhdanova Angelina ,   Vologda Scientific Center of the Russian Academy of Sciences
Published: September 2024

In recent years, during the unstable geopolitical situation, the tourism sector has a vector aimed at domestic tourism. In this regard, there is no doubt that the popularization of such a type of tourism as scientific tourism is relevant for regional and country development. The purpose of the work is to identify the current state and problems of the development of scientific tourism. The main research method is a sociological survey. It was revealed that the main problem is the lack of funding for the activities of scientific staff.