bluuebunny/crossref_metadata_2025 huggingface dataset:
CSA-Net: Channel and Spatial Attention-Based Network for Mammogram and Ultrasound Image Classification
Authors: Naeem Osama Bin , Saleem Yasir
Published: October 2024

Breast cancer persists as a critical global health concern, emphasizing the advancement of reliable diagnostic strategies to improve patient survival rates. To address this challenge, a computer-aided diagnostic methodology for breast cancer classification is proposed. An architecture that incorporates a pre-trained EfficientNet-B0 model along with channel and spatial attention mechanisms is employed. The efficiency of leveraging attention mechanisms for breast cancer classification is investigated here. The proposed model demonstrates commendable performance in classification tasks, particularly showing significant improvements upon integrating attention mechanisms. Furthermore, this model demonstrates versatility across various imaging modalities, as demonstrated by its robust performance in classifying breast lesions, not only in mammograms but also in ultrasound images during cross-modality evaluation. It has achieved accuracy of 99.9% for binary classification using the mammogram dataset and 92.3% accuracy on the cross-modality multi-class dataset. The experimental results emphasize the superiority of our proposed method over the current state-of-the-art approaches for breast cancer classification.
Challenges to Seagrass Restoration in the Indian River Lagoon, Florida
Authors: Main Vivienne A. , Gilligan Morgan K. , Cole Sarah M. , Osborne Todd Z. , Smyth Ashley R. , Simpson Loraé T.
Published: October 2024

Seagrasses provide valuable ecosystem services, including improved water quality, carbon sequestration, and sediment stabilization. Unfortunately, these critical habitats are declining globally due to a range of anthropogenic impacts. Restoration practitioners have made efforts to mitigate loss through the introduction of seagrass transplants. However, seagrass restoration has low success rates and is plagued by water quality concerns and ecosystem degradation. Studies to improve seagrass restoration efforts have targeted different functional taxa to allow for greater stability and recovery of threatened ecosystems, and excluded macro-grazers to limit losses to newly established and restored seagrasses. We hypothesized greater seagrass (Halodule wrightii) health when restored in conjunction with hard clams (Mercenaria mercenaria) and protected from grazers using herbivore exclusion devices (HEDs) in the Indian River Lagoon (IRL), Florida. While our study experienced high rates of seagrass mortality, we were able to observe significant differences in seagrass health between IRL sub-lagoons and observed the positive effects of HEDs on seagrass health. The observed high species mortality highlights how restoration in the IRL is hindered by biotic and abiotic stressors, site selection, and a lack of clear restoration protocols. As we see ongoing declines in water quality and loss of foundational species, informed site selection, greater understanding of grazer presence, and multi-species restoration will provide an informed approach for future seagrass restoration projects globally.
Assessing Codend Mesh Selectivity: Comparing Diamond and Square Mesh Codend in the Red Sea Shrimp Trawl Fishery of Saudi Arabia
Authors: Santucci Ronald Grech , Tosunoğlu Zafer , Cilbiz Mehmet , Charles Santhosh Kumar , Gireesh Sheeja , Kadengal Sirajudheen Thayyil , Adam Adel Mohamed S. , Tıraşın Eyüp Mümtaz , Ünal Vahdet , Dimech Mark
Published: October 2024

This study assessed catch composition, size selectivity, and fishing efficiency of demersal trawls targeting penaeid shrimp species in the Red Sea. It first compared the currently used diamond mesh codends in two fishing areas, Al Qunfudhah and Jazan, and then compared alternative square mesh codends to diamond mesh codends in Jazan. A total of 33 valid hauls were conducted in 2023, yielding 10,869 kg of total catch. The results showed that the square mesh codend significantly improved size selectivity, particularly for Penaeus semisulcatus and Metapenaeus monoceros, with L50 (50% retention length) values closer to their size at first maturity. The fishing efficiency indicators revealed a reduced retention probability for undersized individuals with square mesh codends. Additionally, bycatch discard rates decreased, indicating potential benefits for ecosystem conservation. This study suggests incorporating square mesh codends into fishery management regulations to enhance size selectivity and reduce bycatch during Red Sea shrimp trawling. Establishing a legal minimum landing size requirement is recommended to complement these efforts and promote sustainable fishing practices.
State of the Field: Cytotoxic Immune Cell Responses in C. neoformans and C. deneoformans Infection
Authors: Okafor Elizabeth C. , Nielsen Kirsten
Published: October 2024

Cryptococcus neoformans is an environmental pathogen that causes life-threatening disease in immunocompromised persons. The majority of immunological studies have centered on CD4+ T-cell dysfunction and associated cytokine signaling pathways, optimization of phagocytic cell function against fungal cells, and identification of robust antigens for vaccine development. However, a growing body of literature exists regarding cytotoxic cells, specifically CD8+ T-cells, Natural Killer cells, gamma/delta T-cells, NK T-cells, and Cytotoxic CD4+ T-cells, and their role in the innate and adaptive immune response during C. neoformans and C. deneoformans infection. In this review, we (1) provide a comprehensive report of data gathered from mouse and human studies on cytotoxic cell function and phenotype, (2) discuss harmonious and conflicting results on cellular responses in mice models and human infection, (3) identify gaps of knowledge in the field ripe for exploration, and (4) highlight how innovative immunological tools could enhance the study of cytotoxic cells and their potential immunomodulation during cryptococcosis.
Assessing the Pathogenicity of Berkeleyomyces rouxiae and Fusarium oxysporum f. sp. vasinfectum on Cotton (Gossypium hirsutum) Using a Rapid and Robust Seedling Screening Method
Authors: Chen Andrew , Le Duy P. , Smith Linda J. , Kafle Dinesh , Aitken Elizabeth A. B. , Gardiner Donald M.
Published: October 2024

Cotton (Gossypium spp.) is the most important fibre crop worldwide. Black root rot and Fusarium wilt are two major diseases of cotton caused by soil-borne Berkeleyomyces rouxiae and Fusarium oxysporum f. sp. vasinfectum (Fov), respectively. Phenotyping plant symptoms caused by soil-borne pathogens has always been a challenge. To increase the uniformity of infection, we adapted a seedling screening method that directly uses liquid cultures to inoculate the plant roots and the soil. Four isolates, each of B. rouxiae and Fov, were collected from cotton fields in Australia and were characterised for virulence on cotton under controlled plant growth conditions. While the identities of all four B. rouxiae isolates were confirmed by multilocus sequencing, only two of them were found to be pathogenic on cotton, suggesting variability in the ability of isolates of this species to cause disease. The four Fov isolates were phylogenetically clustered together with the other Australian Fov isolates and displayed both external and internal symptoms characteristic of Fusarium wilt on cotton plants. Furthermore, the isolates appeared to induce varied levels of plant disease severity indicating differences in their virulence on cotton. To contrast the virulence of the Fov isolates, four putatively non-pathogenic Fusarium oxysporum (Fo) isolates collected from cotton seedlings exhibiting atypical wilt symptoms were assessed for their ability to colonise cotton host. Despite the absence of Secreted in Xylem genes (SIX6, SIX11, SIX13 and SIX14) characteristic of Fov, all four Fo isolates retained the ability to colonise cotton and induce wilt symptoms. This suggests that slightly virulent strains of Fo may contribute to the overall occurrence of Fusarium wilt in cotton fields. Findings from this study will allow better distinction to be made between plant pathogens and endophytes and allow fungal effectors underpinning pathogenicity to be explored.
Hypoglycemic Properties of Leccinum scabrum Extracts—An In Vitro Study on α-Glucosidase and α-Amylase Inhibition and Metabolic Profile Determination
Authors: Ferraro Valeria , Spagnoletta Anna , Rotondo Natalie Paola , Marsano René Massimiliano , Miniero Daniela Valeria , Balenzano Gaetano , De Palma Annalisa , Colletti Alessandro , Gargano Maria Letizia , Lentini Giovanni , Cavalluzzi Maria Maddalena
Published: October 2024

Type-2 diabetes affects an increasing percentage of the world’s population and its control through dietary management, involving the consumption of health-promoting foods or their derived supplements, is a common strategy. Several mushroom species have been demonstrated to be endowed with antidiabetic properties, resulting from their ability in improving insulin sensitivity and production, or inhibiting the carbohydrate-hydrolyzing enzymes α-amylase and α-glucosidase. This study aimed to investigate for the first time the hypoglycemic properties of the edible mushroom Leccinum scabrum (Bull.) Gray. Mushroom extracts were prepared through the microwave-assisted extraction (MAE) technique using green solvents with different polarity degrees. The inhibition activity of all the obtained extracts on both α-glucosidase and α-amylase was evaluated and the highest activity was observed for the EtOAc extract which showed an IC50 value about 60-fold lower than the reference compound 1-deoxynojirimycin (DNJ) on α-glucosidase (0.42 ± 0.02 and 25.4 ± 0.6 µg/mL, respectively). As expected on the basis of the literature data concerning both α-glucosidase and α-amylase inhibition, a milder inhibition activity on pancreatic α-amylase was observed. Preliminary in vivo tests on Drosophila melanogaster carried out on the most active obtained extract (EtOAc) confirmed the in vitro observed hypoglycemic activity. Finally, the EtOAc extract metabolic profile was determined through GC-MS and HRMS analyses.
A Treasure Trove of Urban Microbial Diversity: Community and Diversity Characteristics of Urban Ancient Ginkgo biloba Rhizosphere Microorganisms in Shanghai
Authors: Mao Jieying , Wang Qiong , Yang Yaying , Pan Feng , Zou Ziwei , Su Xiaona , Wang Yi , Liu Wei , Tang Yaohua
Published: October 2024

Rapid urbanization has exerted immense pressure on urban environments, severely constraining the growth of ancient trees. The growth of ancient trees is closely linked to the microbial communities in their rhizospheres, and studying their community characteristics may provide new insights into promoting the growth and rejuvenation of ancient trees. In this study, the rhizosphere soil and root systems of ancient Ginkgo biloba trees (approximately 200 years old) and adult G. biloba trees (approximately 50 years old) in Shanghai were selected as research subjects. Phospholipid fatty acid (PLFA) analysis and high-throughput sequencing were employed to investigate the diversity of microbial communities in the G. biloba rhizosphere. The results indicated that the 19 PLFA species selected to characterize the soil microbial community structure and biomass were present in the rhizosphere soil of both ancient and adult G. biloba trees. However, the total microbial biomass and the microbial biomass in the rhizosphere soil of ancient G. biloba were lower than the microbial biomass in the rhizosphere soil of adult G. biloba. The biomasses of Gram-negative bacteria (G−), arbuscular mycorrhizal fungi (AMF), and protozoans (P) were significantly different. Total phosphorus, organic matter, and pH may be the key factors influencing the soil microbial community in the rhizosphere zone of ancient G. biloba. An in-depth study of AMF showed that the roots and rhizosphere soil of G. biloba contained abundant AMF resources, which were assigned to 224 virtual taxa using the MaarjAM reference database, belonging to four orders, ten families, and nineteen genera. The first and second most dominant genera were Glomus and Paraglomus, respectively. Archaeospora and Ambispora were more dominant in the rhizosphere than the roots. Furthermore, the abundance of live AMF was significantly higher in ancient G. biloba than in adult G. biloba. Therefore, future research should focus on the improvement of soil environmental characteristics and the identification and cultivation of indigenous dominant AMF in the rhizosphere of ancient G. biloba, aiming for their effective application in the rejuvenation of ancient trees.
Assessment of Carbon Stock and Sequestration Dynamics in Response to Land Use and Land Cover Changes in a Tropical Landscape
Authors: Bera Dipankar , Chatterjee Nilanjana Das , Dinda Santanu , Ghosh Subrata , Dhiman Vivek , Bashir Bashar , Calka Beata , Zhran Mohamed
Published: October 2024

Quantitative analysis of LULC changes and their effects on carbon stock and sequestration is important for mitigating climate change. Therefore, this study examines carbon stock and sequestration in relation to LULC changes using the Land Change Modeler (LCM) and Ecosystem Services Modeler (ESM) in tropical dry deciduous forests of West Bengal, India. The LULC for 2006, 2014, and 2021 were classified using Google Earth Engine (GEE), while LULC changes and predictions were analyzed using LCM. Carbon stock and sequestration for present and future scenarios were estimated using ESM. The highest carbon was stored in forest land (124.167 Mg/ha), and storage outside the forest declined to 13.541 Mg/ha for agricultural land and 0–8.123 Mg/ha for other lands. Carbon stock and economic value decreased from 2006 to 2021, and are likely to decrease further in the future. Forest land is likely to contribute to 94% of future carbon loss in the study region, primarily due to its conversion into agricultural land. The implementation of multiple-species plantations, securing tenure rights, proper management practices, and the strengthening of forest-related policies can enhance carbon stock and sequestration. These spatial-temporal insights will aid in management strategies, and the methodology can be applied to broader contexts.
Effects of Soil Nutrient Restoration Aging and Vegetation Recovery in Open Dumps of Cold and Arid Regions in Xinjiang, China
Authors: Wu Zhongming , Zhu Weidong , Guo Haijun , Zhang Yong , Shen Chaoji , Guo Jing , Liu Ming , Zhao Tuanwei , Teng Hu , Zhu Wanli , Kang Yongfu , Li Gensheng , Guan Weiming
Published: October 2024

Open-pit coal mining inevitably damages the soil and vegetation in mining areas. Currently, the restoration of cold and arid open-pit mines in Xinjiang, China, is still in the initial exploratory stage, especially the changes in soil nutrients in spoil dumps over time. Dynamic remote sensing monitoring of vegetation in mining areas and their correlation are relatively rare. Using the Heishan Open Pit in Xinjiang, China, as a case, soil samples were collected during different discharge periods to analyze the changes in soil nutrients and uncover the restoration mechanisms. Based on four Landsat images from 2018 to 2023, the remote sensing ecological index (RSEI) and fractional vegetation cover (FVC) were obtained to evaluate the effect of mine restoration. Additionally, the correlation between vegetation changes and soil nutrients was analyzed. The results indicated that (i) the contents of nitrogen (N), phosphorus (P), potassium (K), and organic matter (OM) in the soil increased with the duration of the restoration period. (ii) When the restoration time of the dump exceeds 5 years, N, P, K, and OM content is higher than that of the original surface-covered vegetation area. (iii) Notably, under the same restoration aging, the soil in the artificial mine restoration demonstration base had significantly higher contents of these nutrients compared to the soil naturally restored in the dump. (iv) Over the past five years, the RSEI and FVC in the Heishan Open Pit showed an overall upward trend. The slope remediation and mine restoration project significantly increased the RSEI and FVC values in the mining area. (v) Air humidity and surface temperature were identified as key natural factors affecting the RSEI and FVC in cold and arid open pit. The correlation coefficients between soil nutrient content and vegetation coverage were higher than 0.78, indicating a close and complementary relationship between the two. The above results can clarify the time–effect relationship between natural recovery and artificial restoration of spoil dumps in cold and arid mining areas in Xinjiang, further promoting the research and practice of mine restoration technology in cold and arid open pits.
One-Year Effect of Elexacaftor/Tezacaftor/Ivacaftor Therapy on HbA1c Levels and Insulin Requirement in Patients with Insulin-Dependent Cystic Fibrosis-Related Diabetes: A Retrospective Observational Study
Authors: Bassi Marta , Strati Marina Francesca , Spiandorello Gaia , Scalas Marta , Cresta Federico , Calevo Maria Grazia , d’Annunzio Giuseppe , Castellani Carlo , Minuto Nicola , Maghnie Mohamad , Casciaro Rosaria
Published: October 2024

Introduction: The impact of ETI therapy on pulmonary function and nutritional status has been widely studied; the literature on the possible outcomes on glycemic control and insulin requirement in patients affected by CFRD is controversial. Aim: The main objective of our study was to evaluate HbA1c levels in patients with cystic fibrosis-related diabetes (CFRD) after one year of therapy with elexacaftor/tezacaftor/ivacaftor (ETI). The secondary objective was to study the changes in the total daily insulin dose (TDD), pulmonary function and metabolism in this population. Materials and methods: A retrospective single-center observational study was conducted at the Regional Cystic Fibrosis Centre and Diabetology Centre of IRCCS Istituto Giannina Gaslini. The observation period was divided into four different time points: initiation (T0), 3 months (T3mo), 6 months (T6mo) and 12 months (T12mo) of ETI therapy. Demographic and clinical data were collected. The results were then stratified by genotype (homozygous or heterozygous F508del). Results: Twenty-eight patients with CFRD undergoing insulin therapy were included. TDD (IU) significantly decreased at T3mo and T6mo, but not at T12mo, whereas HbA1c decreased significantly at all three times. The number of hospitalizations and pulmonary exacerbations decreased significantly. Conclusion: We demonstrated both improvement in glycemic control (by means of HbA1c) and insulin requirement in insulin-dependent CFRD patients after one year of ETI treatment.
Dynamic Models of Mechanical Seals for Turbomachinery Application
Authors: Badykov Renat , Falaleev Sergei , Benedyuk Maxim , Diligenskiy Dmitriy
Published: October 2024

One of the primary causes of mechanical face seal failure is rotor vibration. Traditional dynamic seal models often cannot fully explain failure mechanisms. The dynamic models of seals proposed in this paper, including those developed by the authors, are valuable for predicting seal dynamics during operation in specific turbomachinery and for explaining the causes of seal failure. The single-mass dynamic model is suitable for analyzing the dynamics of contact mechanical face seals and simply designed dry gas seals. The two-mass dynamic model is used to investigate the operational dynamics processes of classical dry gas seals under complex loading conditions. The three-mass dynamic model is used to study various complex types of mechanical face seals. This model can determine the normal operating condition range and explain leakage mechanisms in the presence of excessive rotor vibrations.
An Optimization Method for Green Permutation Flow Shop Scheduling Based on Deep Reinforcement Learning and MOEA/D
Authors: Lu Yongxin , Yuan Yiping , Sitahong Adilanmu , Chao Yongsheng , Wang Yunxuan
Published: October 2024

This paper addresses the green permutation flow shop scheduling problem (GPFSP) with energy consumption consideration, aiming to minimize the maximum completion time and total energy consumption as optimization objectives, and proposes a new method that integrates end-to-end deep reinforcement learning (DRL) with the multi-objective evolutionary algorithm based on decomposition (MOEA/D), termed GDRL-MOEA/D. To improve the quality of solutions, the study first employs DRL to model the PFSP as a sequence-to-sequence model (DRL-PFSP) to obtain relatively better solutions. Subsequently, the solutions generated by the DRL-PFSP model are used as the initial population for the MOEA/D, and the proposed job postponement energy-saving strategy is incorporated to enhance the solution effectiveness of the MOEA/D. Finally, by comparing the GDRL-MOEA/D with the MOEA/D, NSGA-II, the marine predators algorithm (MPA), the sparrow search algorithm (SSA), the artificial hummingbird algorithm (AHA), and the seagull optimization algorithm (SOA) through experimental tests, the results demonstrate that the GDRL-MOEA/D has a significant advantage in terms of solution quality.
The Effects of Adding TiO2 and CuO Nanoparticles to Fuel on Engine and Hand–Arm Driver Vibrations
Authors: Adelkhani Ali , Nooripour Peyman , Daneshkhah Ehsan
Published: October 2024

Occupant comfort is a key consideration in automobile dynamics, with vibrations potentially causing long-term physical discomfort, especially for drivers. This study investigates the impact of adding TiO2 and CuO nanoparticles to fuel on engine-induced vibrations. Experiments were conducted at various nanoparticle concentrations (0, 50, 100, and 150 ppm) and engine speeds (1000, 2000, and 3000 rpm). Key performance metrics, including kinematic viscosity, density, heating value, thermal conductivity, and brake power (BP), were analyzed. The results indicated that increasing nanoparticle concentration led to a rise in BP. The highest reduction in root mean square (RMS) vibration accelerations occurred at 3000 rpm and 150 ppm, with vibration reductions of 30.33% for CuO and 28.61% for TiO2. Additionally, 8–10% of engine vibrations were transmitted to the steering wheel. The use of 150 ppm CuO nanoparticles resulted in reduced vibration transmission to the steering wheel at all tested speeds. These findings suggest that nanoparticle-enhanced fuels can significantly reduce engine vibrations, potentially improving driver comfort and reducing wear on vehicle components.
Analysis of the Nonlinear Complex Response of Cracked Blades at Variable Rotational Speeds
Authors: Shao Bo , Fan Chenguang , Fu Shunguo , Zeng Jin
Published: October 2024

The operation of an aero-engine involves various non-stationary processes of acceleration and deceleration, with rotational speed varying in response to changing working conditions to meet different power requirements. To investigate the nonlinear dynamic behaviour of cracked blades under variable rotational speed conditions, this study constructed a rotating blade model with edge-penetrating cracks and proposes a component modal synthesis method that accounts for time-varying rotational speed. The nonlinear response behaviours of cracked blades were examined under three distinct operating conditions: spinless, steady speed, and non-constant speed. The findings indicated a competitive relationship between the effects of rotational speed fluctuations and unbalanced excitation on crack nonlinearity. Variations in rotational speed dominated when rotational speed perturbation was minimal; conversely, aerodynamic forces dominated when the effects of rotational speed were pronounced. An increase in rotational speed perturbation enhanced the super-harmonic nonlinearity induced by cracks, elevated the nonlinear damage index (NDI), and accentuated the crack breathing effect. As the perturbation coefficient increased, the super-harmonic nonlinearity of the crack intensified, resulting in a more complex vibration form and phase diagram.
Design of Connector Assembly Equipment for the Automotive Industry
Authors: Curralo Pedro M. P. , Campilho Raul D. S. G. , Pereira Joaquim A. P. , Silva Francisco J. G.
Published: October 2024

The automotive industry is one of the most demanding sectors of all manufacturing industries due to its competitiveness. It is necessary to innovate through the implementation of automated and robotic equipment, leading to cycle time and labor cost reduction. This work aims to design semi-automatic equipment to assemble cabling connectors used in the automotive sector, replacing a manual process currently taking place in an automotive components company. In the proposed equipment, the operator places a connector in the equipment, and the components (pins and seals) are automatically inserted. A vision sensor with artificial intelligence then confirms the correct application. The equipment operation defined as Finite Element Method (FEM) was applied for structural verification; the materials and fabrication processes were detailed; the associated costs were calculated, and the equipment subsets were validated. The design was successfully accomplished, and the imposed requirements were fulfilled, with significant advantages over the current process, providing new knowledge on how semi-automatic systems can be deployed to enhance the productivity and quality of manufacturing processes. The design principles and insights gained from this work can be applied to other automation challenges, particularly where manual processes need to be replaced by more efficient semi-automatic or automatic systems. The modularity of the overall solution and the design concepts of the component inserter, component feeder, and assembly process allow for its use in different assembly scenarios beyond the automotive sector, such as electronics or aerospace, providing a contribution to increased competitiveness and survival in the global market.
Simulation and Experimental Study of Ultrasonic Vibratory Grinding of Internal Splines
Authors: Zhao Zemin , Zhou Shuangshuang , Liu Qiang , Zhang Long , Shen Bin , Han Jiaming
Published: October 2024

As an important component of mechanical transmission systems, internal splines are widely used in aerospace, industrial equipment, and other fields. However, internal splines are prone to deformation and shrinkage after heat treatment. At present, most internal splines with a pitch circle diameter greater than φ60 mm can be processed and shaped by ordinary corundum grinding wheels, but there is no effective processing method for the shaping of small- and medium-sized internal splines. This paper establishes a single abrasive material removal model; uses Abaqus to simulate three-body free grinding; and analyzes the effects of abrasive rotation angle, rotation speed, and grinding depth on material removal under different conditions. By comparing the tooth lead deviation and tooth direction deviation before and after internal spline grinding, the experimental results show that after ultrasonic vibration grinding, the internal spline tooth profile deviation is reduced by 41.9%, and the tooth direction deviation is reduced by 44.1%, which provides a new processing method for the deformation recovery of internal splines after heat treatment.
Active Disturbance Rejection Control of Engine Speed in Series Hydraulic Hybrid Power System
Authors: Guo Zhiqiang , Luo Junlin , Liu Yuwei
Published: October 2024

In this paper, a novel series hydraulic hybrid powertrain is proposed for a three-axis all-terrain vehicle. The engine drives two variable displacement pumps responsible for driving and steering, respectively. A variable displacement motor is connected to the ring gear of the planetary coupling mechanism to drive the vehicle and a fixed-displacement motor is connected to the sun gear to steer the vehicle. The active disturbance rejection control with feedforward control is employed to control the engine speed. The engine speed is controlled in a close-looped manner by adjusting the engine throttle. The controller parameters are decided by analyzing the influence of each parameter on the controller performance by means of the control variable method. The simulation results indicate that the proposed control strategy enables the vehicle to obtain better engine speed following and anti-disturbance performance. An all-terrain prototype is established and field tests are carried out to verify the effectiveness of the design and control strategy of the series hydraulic hybrid powertrain for the all-terrain vehicle.
Short-Period Skyrmion Crystals in Itinerant Body-Centered Tetragonal Magnets
Authors: Hayami Satoru
Published: October 2024

In this study, we investigate the stability of a magnetic skyrmion crystal with short-period magnetic modulations in a centrosymmetric body-centered tetragonal system. By performing the simulated annealing for the spin model, incorporating the effects of the biquadratic interaction and high-harmonic wave–vector interaction in momentum space, we find that the double-Q square skyrmion crystal consisting of two spin density waves is stabilized in an external magnetic field. We also show that double-Q states appear in both low- and high-field regions; the low-field spin configuration is characterized by an anisotropic double-Q modulation consisting of a superposition of the spiral wave and sinusoidal wave, while the high-field spin configuration is characterized by an isotropic double-Q modulation consisting of a superposition of two sinusoidal waves. Furthermore, we show that the obtained multiple-Q instabilities can be realized for various ordering wave vectors. The results provide the possibility of realizing the short-period skyrmion crystals under the body-centered tetragonal lattice structure.
Modeling the Dynamics of Prosthetic Fingers for the Development of Predictive Control Algorithms
Authors: García-Ortíz José Vicente , Mora Marta C. , Cerdá-Boluda Joaquín
Published: October 2024

In the field of biomechanical modeling, the development of a prosthetic hand with dexterity comparable to the human hand is a multidisciplinary challenge involving complex mechatronic systems, intuitive control schemes, and effective body interfaces. Most current commercial prostheses offer limited functionality, typically only one or two degrees of freedom (DoF), resulting in reduced user adoption due to discomfort and lack of functionality. This research aims to design a computationally efficient low-level control algorithm for prosthetic hand fingers to be able to (a) accurately manage finger positions, (b) anticipate future information, and (c) minimize power consumption. The methodology employed is known as model-based predictive control (MBPC) and starts with the application of linear identification techniques to model the system dynamics. Then, the identified model is used to implement a generalized predictive control (GPC) algorithm, which optimizes the control effort and system performance. A test bench is used for experimental validation, and the results demonstrate that the proposed control scheme significantly improves the prosthesis’ dexterity and energy efficiency, enhancing its potential for daily use by people with hand loss.
Assessing Different Two-Stage Stochastic Models for Optimizing Food Bank Networks’ Operations During Natural Disasters
Authors: Ogazón Esteban , Smith Neale R. , Ruiz Angel
Published: October 2024

Humanitarian logistics face significant challenges during natural disasters due to operational uncertainties. Humanitarian logistics networks such as food banks must manage both regular operations and disaster-induced supply and demand. The study aims to develop and assess two-stage stochastic models that support decision-making under these dual operations. We evaluate various decisional strategies through extensive numerical experiments inspired in the operation of the food bank network Bancos de Alimentos de México (BAMX), highlighting the importance of suitable timeframes for reactive and anticipative decisions. The findings offer valuable insights for managers in balancing routine and emergency responses efficiently.
Maternal Dietary Deficiencies in Folic Acid and Choline Change Metabolites Levels in Offspring after Ischemic Stroke
Authors: Anwar Faizan , Mosley Mary-Tyler , Jasbi Paniz , Chi Jinhua , Gu Haiwei , Jadavji Nafisa M.
Published: October 2024

Background/objectives: Ischemic stroke is a major health concern, and nutrition is a modifiable risk factor that can influence recovery outcomes. This study investigated the impact of maternal dietary deficiencies in folic acid (FADD) or choline (ChDD) on the metabolite profiles of offspring after ischemic stroke. Methods: A total of 32 mice (17 males and 15 females) were used to analyze sex-specific differences in response to these deficiencies. Results: At 1-week post-stroke, female offspring from the FADD group showed the greatest number of altered metabolites, including pathways involved in cholesterol metabolism and neuroprotection. At 4 weeks post-stroke, both FADD and ChDD groups exhibited significant disruptions in metabolites linked to inflammation, oxidative stress, and neurotransmission. Conclusions: These alterations were more pronounced in females compared to males, suggesting sex-dependent responses to maternal dietary deficiencies. The practical implications of these findings suggest that ensuring adequate maternal nutrition during pregnancy may be crucial for reducing stroke susceptibility and improving post-stroke recovery in offspring. Nutritional supplementation strategies targeting folic acid and choline intake could potentially mitigate the long-term adverse effects on metabolic pathways and promote better neurological outcomes. Future research should explore these dietary interventions in clinical settings to develop comprehensive guidelines for maternal nutrition and stroke prevention.
A Net Shape Profile Extraction Approach for Exploring the Forming Appearance of Inclined Thick-Walled Structures by Wire Arc Additive Manufacturing
Authors: Zheng Yexing , Li Yongzhe , Zhou Yijun , Wang Xiaoyu , Zhang Guangjun
Published: October 2024

Wire arc additive manufacturing (WAAM) offers a viable solution for fabricating large-scale metallic parts, which contain various forms of inclined thick-walled structure. Due to the variety of heat dissipation conditions at different positions, the inclined thick-walled structure is a major challenge in fabrication that may produce collapses and defects. However, there is a lack of effective sensing method for acquiring the forming appearance of individual beads in the structure. This paper proposes a novel approach for extracting individual bead profiles during the WAAM process. The approach utilizes a structured-laser sensor to capture the morphology of the surface before and after deposition, thereby enabling an accurate acquisition of the bead profile by integrating the laser stripes. Utilizing the proposed approach, the research investigated the forming mechanism of beads in inclined thick-walled components that were fabricated by various deposition parameters. The width of the overlapping area at the overhanging feature decreased as the layer number increased, while the height of the same area increased. The height of the overlapping area in each layer increased with an increase in deposition current and decreased when the deposition speed was increased. These phenomena suggest that the heat input is a major factor that influences the formation of the overhanging feature. Both the deposition current and deposition velocity influence heat input, and thereby have an effect in enhancing the geometrical accuracy of an overhanging feature. The experimental results indicate that the proposed approach facilitates morphology change investigation, providing a sufficient reference for optimizing deposition parameters.
In-Depth Theoretical Investigations of Borazine’s Aromaticity: Tailoring Electron Delocalization through Substituent Effects
Authors: Tomut Alex-Cristian , Moraru Ionut-Tudor , Nemes Gabriela
Published: October 2024

The current study investigates the influence of several R substituents (e.g., Me, SiH3, F, Cl, Br, OH, NH2, etc.) on the aromaticity of borazine, also known as the “inorganic benzene”. By performing hybrid DFT methods, blended with several computational techniques, e.g., Natural Bond Orbital (NBO), Quantum Theory of Atoms in Molecules (QTAIM), Gauge-Including Magnetically Induced Current (GIMIC), Nucleus-Independent Chemical Shift (NICS), and following a simultaneous evaluation of four different aromaticity indices (para-delocalization index (PDI), multi-centre bond order (MCBO), ring current strength (RCS), and NICS parameters), it is emphasized that the aromatic character of B-substituted (B3R3N3H3) and N-substituted (B3H3N3R3) borazine derivatives can be tailored by modulating the electronic effects of R groups. It is also highlighted that the position of R substituents on the ring structure is crucial in tuning the aromaticity. Systematic comparisons of calculated aromaticity index values (i.e., via regression analyses and correlation matrices) ensure that the reported trends in aromaticity variation are accurately described, while the influence of different R groups on electron delocalization and related aromaticity phenomena is quantitatively assessed based on NBO analyses. The most relevant interactions impacting the aromatic character of investigated systems are (i) the electron conjugations occurring between the p lone pair electrons (LP) on the F, Cl, Br, O or N atoms, of R groups, and the π*(B=N) orbitals on the borazine ring (i.e., LP(R)→π*(B=N) donations), and (ii) the steric-exchange (Pauli) interactions between the same LP and the π(B=N) bonds (i.e., LP(R)↔π(B=N) repulsions), while inductive/field effects influence the aromaticity of the investigated trisubstituted borazine systems to a much lesser extent. This work highlights that although the aromatic character of borazine can be enhanced by grafting electron-donor substituents (F, OH, NH2, O−, NH−) on the N atoms, the stabilization due to aromaticity has only a moderate impact on these systems. By replacing the H substituents on the B atoms with similar R groups, the aromatic character of borazine is decreased due to strong exocyclic LP(R)→π*(B=N) donations affecting the delocalization of π-electrons on the borazine ring.
Novel Thiourea Ligands—Synthesis, Characterization and Preliminary Study on Their Coordination Abilities
Authors: Todorova Stanislava E. , Rusew Rusi I. , Petkova Zhanina S. , Shivachev Boris L. , Kurteva Vanya B.
Published: October 2024

Two series of polydentate N,O,S-ligands containing thiourea fragments attached to a p-cresol scaffold, unsymmetrical mono-acylated bis-amines and symmetrical bis-thioureas, are obtained by common experiments. It is observed that the reaction output is strongly dependent on both bis-amine and thiocarbamic chloride substituents. The products are characterized by 1D and 2D NMR spectra in solution and by single crystal XRD. A preliminary study on the coordination abilities of selected products is performed by ITC at around neutral media.
Interface Synergistic Effect of NiFe-LDH/3D GA Composites on Efficient Electrocatalytic Water Oxidation
Authors: Zhang Jiangcheng , Cao Qiuhan , Yu Xin , Yao Hu , Su Baolian , Guo Xiaohui
Published: October 2024

Currently, NiFe-LDH exhibits an excellent oxygen evolution reaction (OER) due to the interaction of the two metal elements on the layered double hydroxide (LDH) platform. However, such interaction is still insufficient to compensate for its poor electrical conductivity, limited number of active sites and sluggish dynamics. Herein, a feasible two-step hydrothermal strategy that involves coupling low-conductivity NiFe-LDH with 3D porous graphene aerogel (GA) is proposed. The optimized NiFe-LDH/GA (1:1) produced possesses a 257 mV (10 mA cm−2) overpotential and could operate stably for 56 h in an OER. Our investigation demonstrates that the NiFe-LDH/GA has a three-dimensional mesoporous structure, and that there is synergistic interaction between LDH and GA and interfacial reconstruction of NiOOH. Such an interface synergistic coupling effect promotes fast mass transfer and facilitates OER kinetics, and this work offers new insights into designing efficient and stable GA-based electrocatalysts.
Tailoring the Spin Reorientation Transition of Co Films by Pd Monolayer Capping
Authors: Santos Burgos Benito , López-Martín Raúl , De Toro José A. , Binns Chris , Schmid Andreas K. , de la Figuera Juan
Published: October 2024

We have characterized the magnetization easy-axis of ultra-thin Co films (2–5 atomic layers, AL) grown on Ru(0001) when they are capped with a monolayer of Pd. The addition of a Pd monolayer turns the magnetization of 3 and 4 AL-thick Co films from an in-plane to an out-of-plane alignment, but not that of a 5 AL-thick film. These observations are explained in terms of an enhancement of the surface anisotropy. The exposure of the sample to hydrogen, CO or a combination of both gases does not overcome this effect.
Correction: Varela et al. Potential Benefits of Lycopene Consumption: Rationale for Using It as an Adjuvant Treatment for Malaria Patients and in Several Diseases. Nutrients 2022, 14, 5303
Authors: Varela Everton Luiz Pompeu , Gomes Antônio Rafael Quadros , Santos Aline da Silva Barbosa dos , Carvalho Eliete Pereira de , Vale Valdicley Vieira , Percário Sandro
Published: October 2024

The journal’s Editorial Office and Editorial Board are jointly issuing a resolution and removal of the Journal Notice linked to this article [...]
Thai Fermented Soybean (Thua-Nao) Prevents Early Stages of Colorectal Carcinogenesis Induced by Diethylnitrosamine and 1,2-Dimethylhydrazine Through Modulations of Cell Proliferation and Gut Microbiota in Rats
Authors: Taya Sirinya , Dissook Sivamoke , Ruangsuriya Jetsada , Yodkeeree Supachai , Boonyapranai Kongsak , Chewonarin Teera , Wongpoomchai Rawiwan
Published: October 2024

Background: Thua-nao is a traditional fermented soybean product widely consumed in the northern areas of Thailand. There has been little research on the biological activity of Thua-nao, particularly its anticancer properties. Objectives: The objective of this study was to examine the cancer chemopreventive effects of dried Thua-nao on liver and colorectal carcinogenesis induced by carcinogens in rats. Methods: Rats were injected with diethylnitrosamine (DEN) and 1,2-dimethylhydrazine (DMH) to induce preneoplastic lesions. Rats orally received dried Thua-nao for 13 weeks. The preneoplastic lesions, including glutathione S-transferase placental form (GST-P)-positive foci and aberrant crypt foci (ACF), were evaluated in the liver and colon, respectively. The cancer chemopreventive mechanisms of dried Thua-nao on liver and colorectal carcinogenesis were examined. Results: Dried Thua-nao administration suppressed colorectal aberrant crypt foci. Moreover, dried Thua-nao reduced proliferation cell nuclear antigen (PCNA)-positive cells in the colon. Interestingly, dried Thua-nao modulated the gut microbiota in DEN- and DMH-induced rats. Isoflavones, including genistein and daidzein, represent promising chemopreventive agents in dried Thua-nao. Conclusions: In conclusion, these results highlight the cancer chemopreventive effect of dried Thua-nao in DEN and DMH-induced colorectal carcinogenesis through cell proliferation reduction and gut microbiota modulation.
Fish Oil Supplement Mitigates Muscle Injury In Vivo and In Vitro: A Preliminary Report
Authors: Russ David W. , Sehested Courtney , Banford Kassidy , Weisleder Noah L.
Published: October 2024

Background: Following injury, older adults exhibit slow recovery of muscle function. Age-related impairment of sarcolemmal membrane repair may contribute to myocyte death, increasing the need for myogenesis and prolonging recovery. Dietary fish oil (FO) is a common nutritional supplement that may alter plasma membrane composition to enhance the response to membrane injury. Methods: We assessed effects of an 8-week dietary intervention on muscle contractile recovery in aged (22 mo.) rats on control (n = 5) or FO (control + 33 g/kg FO (45% eicosapentaenoic acid; 10% docosahexaenoic acid); n = 5) diets 1-week after contusion injury, as well as adult (8 mo., n = 8) rats on the control diet. Results: Recovery was reduced in aged rats on the control diet vs. adults (63 vs. 80%; p = 0.042), while those on the FO diet recovered similarly to (78%) adults. To directly assess sarcolemma injury, C2C12 cells were cultured in media with and without FO (1, 10, and 100 μg/mL; 24 or 48 h) and injured with an infrared laser in medium containing FM4-64 dye as a marker of sarcolemmal injury. FO reduced the area under the FM4-64 fluorescence-time curve at all concentrations after both 24 and 48 h supplementation. Conclusions: These preliminary data suggest FO might aid recovery of muscle function following injury in older adults by enhancing membrane resealing and repair.
Molecular Characterization of Anaplasma spp. in Cattle from Kazakhstan
Authors: Kadyrova Madina , Ostrovskii Alexandr , Mukanov Kassym , Kassen Amirkhan , Shevtsova Elena , Berdikulov Maxat , Vergnaud Gilles , Shevtsov Alexandr
Published: October 2024

Bovine anaplasmosis is an infectious vector-borne disease caused by bacteria of the genus Anaplasma, which have a wide global distribution and represent a high economic burden for agriculture. The use of molecular genetic techniques has increased our knowledge of the species diversity of Anaplasma spp. and naturally susceptible animals. Monitoring studies allow us to assess the level of infection in herds, as well as the involvement of natural vectors in the processes of maintaining and spreading infection. Despite the high prevalence of Theileria and Babesia in cattle in Kazakhstan, there is no information on the distribution and species diversity of Anaplasma spp in this country. As part of this work, 7027 DNA samples isolated from the whole blood of cattle from 175 settlements in all 17 Kazakhstan regions were PCR-tested for the presence of Anaplasma spp. Anaplasma carriers were found in 1.3% (90 out of 7027) of the tested animals in 9 of the 17 regions of Kazakhstan. The highest percentage of infected animals was recorded in Turkistan (South Kazakhstan) and North Kazakhstan with 4.46% and 2.48% positive samples, respectively. The partial sequencing of 16S rRNA and the groEL gene allowed us to identify five species of Anaplasma: A. centrale, A. marginale, Candidatus Anaplasma Mongolica, A. ovis, and Unknown Anaplasma with infection rates of 0.63%, 0.44%, 0.13%, 0.01%, and 0.01%, respectively.
Potential Involvement of Reactive Oxygen Species in the Bactericidal Activity of Eugenol against Salmonella Typhimurium
Authors: Aljuwayd Mohammed , Olson Elena G. , Abbasi Asim Zahoor , Rothrock Michael J. , Ricke Steven C. , Kwon Young Min
Published: October 2024

There is an increasing need to develop alternative antimicrobials to replace currently used antibiotics. Phytochemicals, such as essential oils, have garnered significant attention in recent years as potential antimicrobials. However, the mechanisms underlying their bactericidal activities are not yet fully understood. In this study, we investigated the bactericidal activity of eugenol oil against Salmonella enterica serovar Typhimurium (S. Typhimurium) to elucidate its mechanism of action. We hypothesized that eugenol exerts its bactericidal effects through the production of reactive oxygen species (ROS), which ultimately leads to cell death. The result of this study demonstrated that the bactericidal activity of eugenol against S. Typhimurium was significantly (p < 0.05) mitigated by thiourea (ROS scavenger) or iron chelator 2,2′-dipyridyl, supporting the hypothesis. This finding contributes to a better understanding of the killing mechanism by eugenol oil.