bluuebunny/crossref_metadata_2025 huggingface dataset:
Students' Perceptions on Using the Flipped Classroom Method to Support Their Self-Regulated Learning in Arabic Speaking Skills: Exploratory Study
Authors: Linur Rahmat , Mubarak Mahfuz Rizqi
Published: June 2022

Many research results have documented that the application of the flipped classroom method in language learning can improve students' speaking skills. However, very little attention has been directed to the impact of the use of flipped classrooms on the students' Self-Regulated Learning (SRL) abilities in improving their Arabic speaking skills. Therefore, this study intends to fill this void by investigating university students' perceptions regarding the impact of using flipped classrooms on their SRL skills in Arabic speaking skills. Exploratory research is used in this study. 21 students were recruited and interviewed to obtain research data. The research data were analyzed by adopting three aspects of Zimmerman's SRL: metacognition, intrinsic motivation, and learning behaviour. The results of this study report that the flipped classroom has been shown to positively impact these three aspects to improve learning outcomes of Arabic speaking skills. This study recommends using flipped classrooms for broader learning of Arabic skills.
Analisis Partisipasi Masyarakat dalam Pengelolaan Sampah di Kecamatan Tuah Madani Kota Pekanbaru
Authors: Febrianti Rahmi , Dewi Ratna , Mardiah Ainun
Published: June 2022

This research explains about community participation in waste management in Tuah Madani District, Pekanbaru City, this research was conducted in Tuah Madani District. The aims of this study are, 1) to find out the form of community participation in waste management in Pekanbaru City District, and 2) to find out the factors that influence community participation in waste management in Tuah Madani District, Pekanbaru City. The informants involved in this research are the Camat, Head of RT, Community, and Waste Bank Management Coordination. This study uses the concept of Regional Regulation Number 08 of 2014 concerning Waste Management. Data collection techniques used were interviews, observations and documentation, while for data analysis used qualitative descriptive techniques with data collection techniques using open interview techniques, observation and field documentation studies. Based on the results of the study, it shows that community participation is categorized as moderate, meaning that the community participates but in implementation, it is still not said to be maximal. Community participation is carried out by doing mutual cooperation and transportation is carried out in the morning and afternoon, twice a week. And there are several factors that influence it, including the character of the residents who don't care, and the location of the Garbage Bank which is far away
Alleviation of neurological and cognitive impairments in rat model of ischemic stroke by 0.5 MAC xenon exposure
Authors: Krukov IA , Ershov AV , Cherpakov RA , Grebenchikov OA
Published: June 2022

The majority of stroke patients have cognitive symptoms and about 50% of them live with neurological deficits that critically limit social adaptation capacities even in the absence of significant motor impairments. The aim of this study was to select the optimal length of 0.5 MAC xenon exposure in order to alleviate the neurological and cognitive impairments in experimental stroke. The focal ischemia-reperfusion injury was modeled in rats (n = 70) ising Longa method. The intervention was immediately followed by inhalation of 0.5 MAC xenon for 30, 60 or 120 min. The neurological deficit was assessed using a 'Limb placement' seven-test battery and the cognitive functionalities were assessed by the Morris water maze test. A 30 min 0.5 MAC xenon exposure provided a 40% increase in the limb placement scores and a 17.6% decrease in the Morris water maze test latency compared with the control group (р = 0.055 and р = 0.08, respectively). With a longer 60 min exposure, the trends became significant, the scores improving 2-fold and by 44.4% compared with the control group (р = 0.01 and р = 0.04, respectively), whereas 120 min exposures afforded 2-fold improvements in both tests (р = 0.01). We conclude that, although 30 min post-stroke inhalations provide negligible benefits in terms of neurological status and learning capacity, prolonged exposure times of 60–120 min afford significant improvement in neurological and cognitive indicators and largely alleviate the deteriorating ischemic damage.
Belok InlB, sekretiruemyj Listeria monocytogenes, kontroliruet vzaimodejstvie vozbuditelya s makrofagami
Authors: Чаленко Я. М. , Абдулкадиева М. М. , Сафарова П. В. , Калинин Е. В. , Слонова Д. А. , Ермолаева С. А.
Published: June 2022

Sposobnost' inficirovat' i razmnozhat'sya v neprofessional'nyh fagocitah lezhit v osnove virulentnosti grampolozhitel'noj bakterii Listeria monocytogenes. V processe protekaniya infekcii zahvachennye kletkami sistemy mononuklearnyh fagocitov listerii ustojchivy k perevarivaniyu i mogut razmnozhat'sya vnutri makrofagov. Odin iz klyuchevyh faktorov patogennosti L. monocytogenes belok internalin V (InlB) vzaimodejstvuet s receptorami kletok mlekopitayushchih c-Met i gC1qR. Pri ego vzaimodejstvii s receptorami, nahodyashchimisya na poverhnosti epitelial'nyh kletok, proiskhodit aktivaciya receptorov, perestrojki citoskeleta i, kak rezul'tat, aktivnaya invaziya bakterij vnutr' neprofessional'nyh fagocitov. Na segodnyashnij den' nichego neizvestno o vliyanii InlB na vzaimodejstvie L. monocytogenes s makrofagami, v to vremya kak oba targetnyh receptora ekspressiruyutsya na poverhnosti makrofagov i vovlecheny v razvitie immunnyh reakcij. Cel'yu raboty bylo opredelit' potencial'noe vliyanie InlB na vzaimodejstvie L. monocytogenes s makrofagami. Ustanovleno, chto 1) nalichie InlB v 3,5 raza dostoverno uluchshaet pogloshchenie L. monocytogenes makrofagami; 2) cherez 24 ch shtammy EGDe∆inlB, EGDe i EGDe∆inlB::pInlB uvelichili svoyu chislennost' vnutri makrofagov v 182,5 ± 16,7, 96 ± 12 i 13,3 ± 3 raz sootvetstvenno; 3) SHtamm EGDe∆inlB::pInlB, komplementirovannyj plazmidnoj kopiej gena inlB, produciroval InlB v 3,3 raza luchshe, chem shtamm EGDe. Takim obrazom my predpolagaem, chto InlB vliyaet na vyzhivaemost' listerij vnutri makrofagov. Poluchennye rezul'taty uglublyayut ponimanie processov vzaimodejstviya vozbuditelya s makrofagami.
The use of adoptive cell therapy for the treatment of SARS-CoV-2 in a patient after allogeneic hematopoietic stem cell transplantation
Authors: Leontyeva M. E. , Sultanova E. R. , Radygina S. A. , Skvortsova Yu. V. , Muzalevskiy Ya. O. , Kurnikova E. E. , Pershin D. E. , Maschan M. A. , Balashov D. N.
Published: June 2022

The COVID-19 pandemic continues to be a major public health threat worldwide. The course of this disease in immunocompromised patients is significantly different from that in healthy subjects, which is associated with the impossibility of virus elimination through their own adaptive immune response. Delayed immune reconstitution after hematopoietic stem cell transplantation (which may take months after the procedure) increases the risk of life-threatening COVID-19 infection necessitating a search for and application of new methods of treatment. T lymphocytes are critically important for viral infection control, and are necessary both for the direct elimination of Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation. The patient's parents gave consent to the use of their child's data, including photographs, for research purposes and in publications.
High order Finite Difference/Discontinuous Galerkin schemes for the incompressible Navier-Stokes equations with implicit viscosity
Authors: Boscheri Walter , Tavelli Maurizio , Paoluzzi Nicola
Published: June 2022

In this work we propose a novel numerical method for the solution of the incompressible Navier-Stokes equations on Cartesian meshes in 3D. The semi-discrete scheme is based on an explicit discretization of the nonlinear convective flux tensor and an implicit treatment of the pressure gradient and viscous terms. In this way, the momentum equation is formally substituted into the divergence-free constraint, thus obtaining an elliptic equation on the pressure which eventually maintains at the discrete level the involution on the divergence of the velocity field imposed by the governing equations. This makes our method belonging to the class of so-called structure-preserving schemes. High order of accuracy in space is achieved using an efficient CWENO reconstruction operator that is exploited to devise a conservative finite difference scheme for the convective terms. Implicit central finite differences are used to remove the numerical dissipation in the pressure gradient discretization. To avoid the severe time step limitation induced by the viscous eigenvalues related to the parabolic terms in the governing equations, we propose to devise an implicit local discontinuous Galerkin (DG) solver. The resulting viscous sub-system is symmetric and positive definite, therefore it can be efficiently solved at the aid of a matrix-free conjugate gradient method. High order in time is granted by a semi-implicit IMEX time stepping technique. Convergence rates up to third order of accuracy in space and time are proven, and a suite of academic benchmarks is shown in order to demonstrate the robustness and the validity of the novel schemes, especially in the context of high viscosity coefficients.
On the strong metric subregularity in mathematical programming
Authors: Osmolovskii Nikolai P. , Veliov Vladimir M.
Published: June 2022

This note presents sufficient conditions for the property of strong metric subregularity (SMSr) of the system of first order optimality conditions for a mathematical programming problem in a Banach space (the Karush-Kuhn-Tucker conditions). The constraints of the problem consist of equations in a Banach space setting and a finite number of inequalities. The conditions, under which SMSr is proven, assume that the data are twice continuously Fréchet differentiable, the strict Mangasarian-Fromovitz constraint qualification is satisfied, and the second-order sufficient optimality condition holds. The obtained result extends the one known for finite-dimensional problems. Although the applicability of the result is limited to the Banach space setting (due to the twice Fréchet differentiability assumptions and the finite number of inequality constraints), the paper can be valuable due to the self-contained exposition, and provides a ground for extensions. One possible extension was recently implemented in Osmolovskii and Veliov (2021).
Village-Based Tourism Performance: Tourist Satisfaction and Revisit Intention
Authors: Zaitul Zaitul , Ilona Desi , Novianti Neva
Published: June 2022

Introduction. Tourist satisfaction and revisit intention have been used to measure tourism performance by the government agency. These two variables were investigated by previous studies but failed to focus on village-based tourism destinations, which are popular in Indonesia. Therefore, this study investigates the effect of cognitive destination image on tourist satisfaction and revisit intention.

Material and methods. It also determines the role of tourist satisfaction as a mediating variable between cognitive destination image and revisit intention using 124 respondents. Cognitive destination image is divided into attractive condition, essential condition, appealing activity, and natural environment. Furthermore, this study employs the structural equation model (SEM) using smart-pls to analyze data.

Results. The result shows that attractive and essential conditions are related to tourist satisfaction, while appealing activity and essential conditions influence the intention to revisit.

Conclusions. Tourist satisfaction associates with the intention to revisit and attractive conditions. However, the function of the tourism satisfaction as a mediating variable between destination image and intention to revisit is partially revealed.
Hemolytic disease of newborn: fokus pada inkompatibilitas ABO
Authors: Sari Teny Tjitra , Muhaimin Riski , Fazlurrahman Umam
Published: June 2022

HDN harus dicurigai bila didapatkan penurunan hemoglobin tanpa tanda perdarahan, peningkatan produksi eritrosit, ikterik pada 24-48 jam pertama, dan direct anti-globulin test positif. Inkompatibilitas ABO merupakan etiologi terbanyak dari HDN. Meskipun mayoritas terjadi pada ibu dengan golongan darah O, namun dilaporkan kasus pada ibu dengan golongan darah A dan B. Antigen pada kelompok darah ABO, terdiri dari antigen-A, antigen-B, dan prekursornya, antigen-H. Antigen-A dan B memiliki beberapa sub grup antigen dan tidak hanya ada di membran eritrosit, namun juga terdapat pada berbagai jaringan tubuh. Berbeda dengan inkompatibilitas rhesus, pada inkompatibilitas ABO sering terjadi pada kehamilan pertama dengan manifestasi yang lebih ringan. Fototerapi merupakan terapi lini pertama hiperbilirubinemia HDN. Bila tidak membaik, dapat diberikan imunoglobulin dan dilakukan transfusi tukar. Terapi farmakologi lain belum direkomendasikan. Transfusi darah dilakukan bila Hb turun signifikan atau terdapat gejala. Deteksi dini dan tatalaksana adekuat menurunkan morbiditas dan mortalitas.
POTENSI EKSTRAK IKAN GABUS TERHADAP KESEMBUHAN LUKA DIABETES
Authors: Prayugo Bambang , Ichwan Muhammad , Yamamoto Zulham
Published: June 2022

Abstrak. Luka diabetes merupakan luka kronis yang berdampak buruk bagi morbiditas, mortalitas, dan psiko-sosio-ekonomi penderita maupun keluarganya. Kondisi hiperglikemia mengakibatkan fase penyembuhan luka tidak berjalan normal. Ekstrak ikan gabus, yang dapat diberikan peroral maupun sebagai bahan kombinasi penutup luka berpotensi terhadap penyembuhan luka diabetes melalui peningkatan jumlah netrofil dan makrofag, neovaskularisasi. Selain itu, ekstrak ikan gabus meningkatkan jumlah fibroblas, deposisi kolagen, peningkatan re-epitelisasi, kekuatan regangan, dan kontraksi pada penyembuhan luka.
Medicolegal Investigation in a Crushed Injury in Lower Limb due to Road Traffic Accident
Authors: Suryadi Taufik , Kulsum Kulsum
Published: June 2022

The prevalence and incidence of traffic accidents resulting in injuries to the extremities are still high enough so that the morbidity and mortality rates increase each year. Extremity injuries that occur as a result of traffic accidents cause damage to bones, muscles, joints and also in blood vessels, which can cause massive bleeding which can result in haemorrhagic shock and lead to death. A reported case of a 41-year-old woman suffered a traffic accident that resulted in her left leg being crushed. According to the medicolegal system in Indonesia, every case of a traffic accident must be made a simultaneous examination between clinical medical aspects and clinical forensics. Medical evidence was collected to produce a medicolegal investigation report. In this case an analysis of how predicted traffic accident events, the impact of trauma, the degree of qualification of injuries to the estimated threat of punishment for the perpetrators who caused injury to victims due to traffic accidents involving extremity.
Tatalaksana katarak kongenital dengan sangkaan Congenital Rubella Syndrome
Authors: Imelda Eva , Hermaya Putri
Published: June 2022

Pendahuluan : Katarak kongenital merupakan  kelainan dimana terjadi kekeruhana pada lensa mata yang terdeteksi sejak lahir. Saat ini katarak kongenital masih menjadi penyebab kebutaan utama pada anak di dunia. Prevalensi 1-15 kasus dalam 10.000 anak, 1-3 kasus dalam 10.000 kelahiran di negara berkembang dan 1.7 – 14.7 kasus dalam 10.000 anak di Asia. Tujuan tatalaksana yaitu membersihkan katarak secepat mungkin untuk mencegah taerjadinya ambliopia.Tujuan : Untuk melaporkan tatalaksana kasus katarak kongenital dengan penyulit Congenital Rubella Syndrome (CRS).Deskripsi Kasus : Seorang anak perempuan uisa 11 tahun dibawa berobat ke poliklinik Pediatrik Oftalmologi dan Strabismus RS Dr. Zainoel Abidin Banda Aceh dengan keluhan utama terdapat bintik putih pada kedua mata sejak lahir. Pasien di diagnosa katarak kongenital dan dilakukan pembedahan yang meliputi aspirasi irigasi, kapsulotomi posterior primer dan vitrektomi anterior dalam pembiusan umum.Kesimpulan : Tujuan tatalaksana kasus katarak kongenital adalah mencegah ambliopia dengan membersihkan katarak sesegera mungkin sehingga prognosis penglihatan lebih baik. Pemilihan tehnik operasi dan rehabilitasi optik merupakan hal penting untuk mencapai fungsi visual yang baik.
Fatores Que Contribuem Para O Reparo Certo Da Primeira Vez: Um Estudo na Jaguar Land Rover
Authors: França Neto Osvaldo Luna de , Firmino Thaís Teles , Melo Fagner José Coutinho de
Published: June 2022

O objetivo do artigo foi analisar os fatores que orientam os técnicos de uma autorizada Jaguar Land Rover no Nordeste a executarem o reparo correto da primeira vez. Este serviço consiste em atender a todas as solicitações do cliente na primeira vez em que são reclamadas no departamento de pós-venda, em conformidade com os direcionamentos de Philip Crosby, o guru da qualidade que idealizou os conceitos “certo da primeira vez” e “zero defeito”. Para tanto, foi utilizada a entrevista, observação e pesquisa documental, que foram analisadas a partir de técnicas interpretativas. Foi verificado que as montadoras de veículos desenvolvem várias ferramentas para atender às demandas dos clientes e, consequentemente, aumentar os níveis de satisfação cada vez mais. Também ficou evidente que o controle da qualidade tem papel crítico no processo, assim como a expertise dos técnicos e a boa divulgação do manual de procedimentos.
Teorias da Administração Pública
Authors: Silva Neide Andrade da
Published: June 2022

No capítulo quatro do livro Teorias da Administração Pública Denhardt, o qual é professor de Administração Pública da Universidade do Arizona, inicia sua discussão, apoiado em uma relevante e vasta literatura de teóricos renomados como Allison, Barnard, Cyert, March, Dahl, Horkheimer, Kaufman, Lindblom, March, Simon e Thompson, afirmando que os comportamentos são parecidos entre organizações públicas e organizações privadas e que os comportamentos são diferentes entre organizações grandes e organizações pequenas.
Apresenta ainda neste texto as críticas de Herbert Simon (1946) às teorias precedentes, pois as teorias administrativas, até então, falavam sobre autoridade, centralização, amplitude de controle e função sem se preocupar com as definições operacionais para esses termos.
Dynamic portfolio formulation using bitcoin and LQ45 stocks
Authors: Anggita Isna , Robiyanto Robiyanto
Published: June 2022

This research aims to evaluate whether dynamic portfolios consisting of bitcoin and LQ45 stocks outperform portfolios composed solely of LQ45 stocks, especially during the Covid-19 pandemic. Accordingly, we use the time-series data of eight stocks and bitcoin from January 1, 2020, to December 31, 2020. We then run the DCC-GARCH method to analyze better the dynamic correlation between assets and the abnormalities of stock return distributions. The findings demonstrate that bitcoin is negatively correlated with LQ45 stocks, and hence, it can be used to hedge against stock assets. Further, we measure the portfolio performance of bitcoin-hedged and unhedged stock portfolios using the Jensen Index, Treynor Index, Sharpe Index, Sortino Ratio, and Omega Ratio. These measures consistently indicate that bitcoin-hedged stocks outperform unhedged stocks. In sum, our study concludes that incorporating bitcoin into portfolio formation improves portfolio performance.
ЧЕРНІВЕЦЬКИЙ ПАРТАПАРАТ І РЕЛІГІЙНЕ ВІДРОДЖЕННЯ БУКОВИНИ НА ЗЛАМІ 80–90-х рр. ХХ ст.
Authors: ЧУРА Василь , КАГАНОВ Юрій
Published: June 2022

Мета дослідження. Наукова розвідка реконструює маловідомі події,пов’язані з особливостям релігійного “ренесансу” північної частини Буковини у другій половині 80–початку 90-х рр. ХХ ст., яка входила до складу УРСР й СРСР від 1940 й 1944 рр. до 1991 р. Відтворення динаміки релігійного відродження подано крізь призму його комуністичної рецепції, що ґрунтувалась на хоча й латентному, але прихильному ставленні проросійського компартійного керівництва Чернівецької області до Російської Православної Церкви та його цілковитому несприйнятті національних Української Греко-Католицької Церкви та Української Автокефальної Православної Церкви. Методологія дослідження. Верифікація негативного сприймання компартійним керівництвом Чернівеччини релігійного відродження національних церков відбувалася із дотриманням принципу історичної об’єктивності. Під час здійснення дослідження було застосовано методи критичного й структурного аналізу й класифікації, систематизації неопублікованих архівних джерел. Висновки базувались на документах трьох обласних архівів, а також сторінках комуністичних і національних періодичних видань та матеріалах інтерв’ю із учасниками подій. Наукова новизна статті полягає у тому, що вперше в українській історичній науці здійснено аналіз причин та наслідків двоякого сприйняття чернівецьким партапаратом релігійного становища регіону, внаслідок його підпорядкованості московському ЦК КПРС, що розглядав РПЦ як один із інструментів насадження російської ментальності в анексованих ним українських землях. Такий розгляд уможливило уведення до наукового обігу нової архівної документальної бази, яка раніше не була оприлюдненою для широкого кола наукових дослідників. Висновки. В історичній науці існує гіпотеза про вибірковість радянської, а відтак російської комуністичної доктрини “войовничого атеїзму” як цілковитого і безповоротного заперечення віри у Бога. Такі подвійні стандарти помітно виявляли себе у критичні для радянської влади часи, коли з метою власного виживання вона свідомо відступала від власних постулатів й пристосовувала їх до вимог часу. Останнім у “черзі” цих проявів був період, коли КПРС-КПУ вичерпала себе як ідеологічний стрижень держави та СРСР – як геополітичний об’єкт. Тоді за московською вказівкою місцевий чернівецький партапарат ілюстрував прихильне ставлення до РПЦ, субсидіював пишне відзначення 1000-ліття хрещення Київської Русі-України у православно-російському форматі й здійснював непримиренне ставлення до УГКЦ й УАПЦ та протестантських церков, керуючись не релігійною, а політичною кон’юнктурою.
ACIDENTES COM ANIMAIS PEÇONHENTOS NO BRASIL: UMA REVISÃO INTEGRATIVA
Authors: Nunes Márcia Luana Correia , Farias Jordani Araújo Cavalcante Ribeiro , Anselmo Daniele Araújo , Anselmo Michelle de Araújo , Andrade Roumayne Fernandes Vieira
Published: June 2022

Considerados como doenças negligenciadas pela Organização Mundial de Saúde, os acidentes com animais peçonhentos são de grande relevância média por apresentarem altos índices de mortalidade e morbidade. Objetivo - O objetivo desta revisão é apresentar os aspectos epidemiológicos e clínicos dos acidentes com animais peçonhentos no Brasil nos últimos dez anos. Métodos - Foram utilizadas publicações que compreendessem os aspectos clínicos e epidemiológicos de estados, regiões ou municípios brasileiros. Para a revisão foram os artigos foram selecionados em maio de 2020, compreendendo os anos de 2010 a 2020. Resultados e Discussão - Os principais acidentes foram relacionados a serpentes peçonhentas e escorpiões. Nas regiões Sudeste, Norte, Centro-Oeste os acidentes ofídicos foram os mais recorrentes, enquanto que, na região Nordeste os acidentes com escorpiões e um estudo da região Sul um estudo destacou o araneísmo como principal acidente. Os sinais e sintomas do ofidismo variaram de acordo com o gênero das serpentes, sendo os acidentes com o gênero Bothrops predominante. Os sintomas recorrentes foram: dor, edema, equimose, hemorragia local e sistêmica e alterações na coagulação. O escorpionismo foi causado principalmente pelo gênero Tityus, sendo os casos graves relacionados ao comprometimento pulmonar. Conclusão - Os tipos de acidentes, bem como os sinais e sintomas do envenenamento apresentam muitas variáveis, como região geográfica, gênero e espécie dos animais. A melhoria da qualidade dos dados epidemiológicos e ampliação da assistência em saúde são fatores essenciais para a redução no número de casos de mortalidade e morbidades decorrentes do envenenamento por animais peçonhentos.
PREVALÊNCIA DE POLIFÁRMACOS EM IDOSOS DO MUNICÍPIO DE FRANCISCO BELTRÃO, PARANÁ
Authors: Steimbach Poliana Elis , Bortoloti Durcelina Schiavoni
Published: June 2022

RESUMOIntrodução: O envelhecimento é um processo em que há diminuição do desempenho ativo dos órgãos e redução expressiva das funções fisiológicas e metabólicas do organismo, de modo que surge uma evolução progressiva para doenças crônicas no decorrer do aumento da idade. Isso faz surgir a necessidade da utilização de multifármacos (polifarmácia ou polifármacos), que, somadas à utilização de medicamentos sem orientação médica, podem junto conduzir os idosos ao desenvolvimento de reações decorrentes de interações farmacológicas. Objetivo: este trabalho teve como objetivo identificar a prevalência de polifármacos em grupo específico de idosos do Município de Francisco Beltrão, Paraná. Métodos: tratou-se de uma pesquisa transversal, cujos dados foram coletados de um banco de dados de pesquisa realizada em 2016 (Prevalência de atividade física e comportamento sedentário em idosos do município de Francisco Beltrão, Paraná). Contou-se com 319 idosos com 60 anos ou mais, de ambos os sexos, residentes no município de Francisco Beltrão. O estudo foi aprovado pelo comitê de ética (Parecer número 1.906.259). Os dados referentes as características da população e o uso de medicação foram analisadas por meio de estatísticas descritivas para a análise de frequências relativas e absolutas nas diferentes variáveis analisadas. As análises foram realizadas nos programas de estatística SPSS 25,0. Resultados: observou-se que dos 319 idosos, 95 (29,8%) relataram consumo frequente de quatro ou mais medicamentos, sendo que a média de quantidade total de medicamentos consumidos por idoso foi de 2,79 ± 2,09 medicamentos. Em relação ao sexo observou-se que, dos idosos classificados com uso de polifármacos, as mulheres tiveram maior prevalência (65,3%) em comparação os homens (34,7). Já para a faixa etária, verificou-se que as idades de 60 a 69 anos foi a maior taxa de poli fármacos (51,6%), contudo não foram identificadas diferenças significantes de poli fármacos entre os sexos ou idades (p > 0,05). O consumo de medicamento para Hipertensão Arterial foi o mais relatado pelos idosos avaliados. Conclusão: conclui-se que, 29,8% dos idosos deste estudo relataram consumir com frequência quatro ou mais medicamentos, e que as mulheres, idosos que não sabiam ler e os idosos mais jovens são os que apresentaram maior prevalência de polifarmácia.
Formulation optimization of omeprazole loaded pH sensitive mucoadhesive microspheres for site specific delivery
Authors: Rani Deepika , Chauhan Bhupendra , Chaudhary Veenu , Sharma Reetu , Singh Ranjit
Published: June 2022

The objective of the research work was to formulate, optimize and evaluate the omeprazole loaded enteric coated microspheres. Microspheres were successfully prepared by orifice-ionic gelation process and optimized by using 32 full factorial design using two independent variables (concentration of sodium alginate and stirring speed) and three dependent variables (in vitro drug release, encapsulation efficiency and in vitro mucoadhesion). The effect of all variables was assessed by surface response methodology. The prepared formulations were evaluated in terms of micromeritic properties, percentage yield, particle size, in vitro drug release, encapsulation efficiency, zeta potential and in vitro mucoadhesion. Based on response surface methodology, the F6 formulation was considered as best with an entrapment efficiency of 85.45%, mucoadhesion of 91.04% and in vitro drug release of 55.39% in12 hrs. The stability study indicated that none of the formulation showed significant changes in percent residual drug content. The present study reports the successful preparation of omeprazole loaded enteric coated microspheres for effective prolongation of the duration of action and it also protects the drug from the acidic environment of stomach, thus increasing the therapeutic outcome.
Graphene oxide: Synthesis, Characterization and its Applications
Authors: Goyat Rohit , Singh Joginder
Published: June 2022

Graphene oxide, one of the allotropes of carbon, has sp2 hybridized carbon atoms arranged in a two-dimensional honeycomb lattice. In last three to four decades, lot of research interest has been shown in it by virtue of its large surface area, high thermal and electrical conductivity. It has versatile and tunable carbon backbone which can lead to facile functionalization and incorporation into a variety of products. It has been extensively studied for applications in electronics, catalysis, sensors, energy conversion and storage etc. Besides these versatile applications and properties, graphene itself cannot achieve the goal, it needs incorporation of different other nanomaterials and vice- versa. Hereby we tried to give a mini but critical analysis of graphene oxide synthesis, its structure elucidation, characterization and application in various fields.
Good Vibrations: Calculating Excited State Frequencies Using Ground State Self-Consistent Field Models
Authors: Abou Taka Ali , Corzo Hector , Pribram-Jones Aurora , Hratchian Hrant
Published: June 2022

△SCF methods have proven to be reliable computational tools for the assignment and interpretation of photoelectron spectra of isolated molecules. These results have increased the interest in △SCF techniques for electronic excited states based on improved algorithms that prevent convergence to ground states. In this work, one of these △SCF improved algorithms is studied to demonstrate its ability to explore the molecular properties for excited states. Results from △SCF calculations for a set of representative molecules are compared with results obtained using time-dependent density functional theory and single substitution configuration interaction method. For the △SCF calculations, the efficacy of a spin-purification technique is explored to remedy some of the spin-contamination presented in some of the SCF solutions. The obtained results suggest that the proposed projection-based SCF scheme, in many cases, alleviates the spin--contamination present in the SCF single determinants, and provides a computational alternative for the efficient exploration of the vibrational properties of excited states molecules.
Mebendazole’s Conformational Space and its Predicted Binding to Human Heat-Shock Protein 90
Authors: Fiedler Walter , Freisleben Fabian , Wellbrock Jasmin , Kirschner Karl
Published: June 2022

Recent experimental evidence suggest that mebendazole, a popular antiparasitic drug, binds to heat shock protein 90 (Hsp90) and inhibit acute myeloid leukemia cell growth. In this study we use quantum mechanics (QM), molecular similarity and molecular dynamics (MD) calculations to predict possible binding poses of mebendazole to the adenosine triphosphate (ATP) binding site of Hsp90. Extensive conformational searches and minimization of the five mebendazole tautomers using MP2/aug-cc-pVTZ theory level resulted in 152 minima. Mebendazole-Hsp90 complex models were subsequently created using the QM optimized conformations and protein coordinates obtained from experimental crystal structures that were chosen through similarity calculations. Nine different poses were identified from a total of 600 ns of explicit solvent, all-atom MD simulations using two different force fields. All simulations support the hypothesis that mebendazole is able to bind to the ATP binding site of Hsp90.
Versatile X-ray operando electrolysis cell
Authors: Moss Asger , Hätinen Joel , Kúš Peter , Garg Sahil , Mirolo Marta , Chorkendorff Ib , Seger Brian , Drnec Jakub
Published: June 2022

We here present a design for a versatile electrochemical cell designed for X-ray operando studies of Membrane Electrode Assembly (MEA) based electrolysis. The cell has been tested for CO2 electrolysis performance and for various X-ray techniques.
Alternative and facile production pathway towards obtaining high surface area PtCo/C intermetallic catalysts for improved PEM fuel cell performance
Authors: Heizmann Philipp A. , Nguyen Hien , von Holst Miriam , Fischbach Andreas , Kostelec Mitja , Javier Gonzalez Lopez Francisco , Bele Marjan , Pavko Luka , Đukić Tina , Šala Martin , Ruiz-Zepeda Francisco , Klose Carolin , Gatalo Matija , Hodnik Nejc , Vierrath Severin , Breitwieser Matthias
Published: June 2022

The design of catalysts with stable and finely dispersed platinum or platinum alloy nanoparticles on the carbon support is key in controlling the performance of proton exchange membrane (PEM) fuel cells. In the present work, an intermetallic PtCo/C catalyst is synthesized via double-passivation galvanic displacement. TEM and XRD confirm a significantly narrowed particle size distribution for the catalyst particles compared to commercial benchmark catalysts (Umicore PtCo/C). Only about 10 % of the mass fraction of PtCo particles show a diameter larger than 8 nm, whereas up to > 35 % for the reference systems. This directly results in a considerable increase in electrochemically active surface area (96 m² g-1 vs. > 70 m² g-1), which confirms the more efficient usage of precious catalyst metal in the novel catalyst. Single-cell tests validates this finding by improved PEM fuel cell performance. Reducing the cathode catalyst loading from 0.4 mg cm-² to 0.25 mg cm-² resulted in a power density drop at application-relevant 0.7 V of only 4 % for the novel catalyst, compared to the 10 % and 20 % for the commercial benchmarks reference catalysts.
Discovery of Amino Acid fingerprints transducing their amphoteric signatures by field-effect transistors
Authors: Kumar Naveen , Dhar Rakshita Pritam Singh , García César Pascual , Georgiev Vihar
Published: June 2022

Protein sequencing is key to many biological fields to advance science and prospect medical applications based on proteomics. However, even with advanced techniques such as mass spectrometry it is hard to detect the fluctuations in AA sequences and optical/geometrical isomers, and cannot provide wide access to ex-novo sequencing of low quantities of proteins. We are presenting a new and disruptive method based on FET sensors for AA/polypeptide detection. We show unique signals (fingerprints) of every single AA and polypeptide mutations by solving the site-binding model self-consistently with the Gouy-Chapman-Stern model. The surface potential (Ψo), 2nd gradient of the surface potential (δΨo2/δpH2) and total surface capacitance (CT) are used as fingerprint signals to differentiate between the amino acids including the drain current variation as the signal transduction. These fingerprints are based on orthogonal properties of the AAs, which are the different proton affinities of each of the radicals, their dielectric constant and effective length, which is sensitive to the relative positions of the radicals to distinguish between isomers. We studied the generation of signals and proposed a novel noise-filtering technique based on the Fast-Fourier Transform (FFT) and the significantly improved analytical model which is solved iteratively to reduce data loss. The minimum combined fingerprint resolution is 0.1 units of pH for the separation of singularities found in δΨo2/δpH2, linked to the minimum capacitance of the AAs with a needed resolution of 0.01mF/m2 for surface densities of 1014cm-2, and which can be normalized to lower densities. The effect of noise (>SNR=10dB) and silanol sites can be negated by correlating the AAs signatures from δΨo2/δpH2 and capacitance. Thus, the designed methodology and approach can help immensely in designing a new and efficient tool for protein sequencing while solving the problems related to the signal transduction of sensors.
Synergistic Porosity and Charge Effects in a Supramolecular Porphyrin Cage Promote Efficient Photocatalytic CO2 Reduction
Authors: An Lun , De La Torre Patricia , Smith Peter , Narouz Mina , Chang Christopher
Published: June 2022

We present a supramolecular approach to catalyzing photochemical CO2 reduction in confined spaces through synergistic second-sphere porosity and charge effects. A porous iron porphyrin organic cage bearing 24 cationic groups, FePB-2(P), was made via post-synthetic modification of a versatile alkyne-functionalized supramolecular synthon. FePB-2(P) promotes the photochemical CO2 reduction reaction (CO2RR) with 97% selectivity for CO product, achieving turnover numbers (TON) exceeding 7000 and initial turnover frequencies (TOFmax) reaching 1400 min-1. The cooperativity between second-sphere porosity and charge effects results in a 41-fold increase in activity relative to the parent FeTPP catalyst, which is far greater than analogs that augment catalysis through porosity (FePB-3(N), 4-fold increase) or charge (Fe-p-TMA, 6-fold increase) alone. This work establishes that multiple, synergistic pendants in the secondary coordination sphere can be leveraged as a design element to augment catalysis at primary active sites within confined spaces.
Epistemología de las investigaciones cuantitativas y cualitativas
Authors: Huamán Rojas Jesús Anatolio , Treviños Noa Liliana Lesnny , Medina Flores Wilmer Augusto
Published: June 2022

El presente artículo es fruto de una investigación básica y de gabinete que indaga los criterios epistemológicos y ontológicos que están detrás de la clasificación de la investigación en cuantitativas y cualitativas; para ello el problema general que orientó la investigación fue develar las bases epistemológicas que sostienen la clasificación de la investigación científica en cuantitativas y cualitativas; y, vinculados a esa epistemología, los problemas específicos tratan del desentrañamiento de la noción de realidad, objetividad y subjetividad. Teniendo en cuenta el problema general, la hipótesis de trabajo fue que la base epistemológica que sostiene dicha clasificación es la hermenéutica, la fenomenología filosófica, así mismo, la noción de realidad, objetividad y subjetividad son de carácter nominalista. La investigación realizada señala que las bases epistemológicas que sirven de fundamento a la investigación cuantitativa, son las mismas que fundamentan la clasificación de la investigación en cuantitativas y cualitativas, agregándose a ella el historicismo diltheano y el constructivismo filosófico. Así mismo, se hace una discusión de los resultados obtenidos con las epistemologías sostenidas en esta investigación.
Moving from Support for Decision-making to Substitute Decision-making: Legal Frameworks and Perspectives of Supporters of Adults with Intellectual Disabilities
Authors: Then Shih-Ning , Carney Terry , Bigby Christine , Wiesel Ilan , Smith Elizabeth , Douglas Jacinta
Published: June 2022

The United Nations Convention on Rights of Persons with Disabilities (UNCRPD) has significantly changed the way our society views models of decision-making for adults with cognitive impairment. The formerly-accepted substitute decision-making models – where a person can legally make decisions for an individual, often guided by the ‘best interests’ principle – are considered less desirable than supported decision-making which prioritises an individual’s ‘will, preferences and rights’. However, disciplinary differences in understandings about what these concepts entail and how they should look in policy, legal and practice frameworks persist.

For many, supported decision-making is experienced through informal support for decision-making through close family, and in the absence of a legal appointment. What this support looks like and whether it can help achieve the aim of greater participation by people with intellectual disability is still being empirically examined. In addition, the circumstances when that support moves into informal substitute decision-making is largely unexplored. It is also unclear whether the reasons for such a shift mirror the legal requirements for the appointment of a formal substitute decision-maker under Australian law.

This paper uses a subset of qualitative data from interviews with parents who act as supporters to adults who have an intellectual disability. The overall aim of the study was to explore the impact of training in applying a practice framework (the La Trobe Support for Decision Making Practice Framework) about effective support for decision-making. We show that promising development is reported from the impact of capacity-building training for supporters, with evidence that the decision-making capabilities of adults with intellectual disabilities can be seen to shift over a period of time and training informal supporters can be effective in moving the dial as to when a supporter finds it necessary to step in and make a substitute decision. However, we also demonstrate that considerations of ‘risk’ and future opportunities for the supported adult are nuanced factors taken into account by supporters who shifted into a substitute decision-maker role and this is not well accounted for in our legal frameworks.
Class Actions and Human Rights Litigation in Australia: Realising the Potential
Authors: Calnan Scott
Published: June 2022

Most commentary and, indeed, most controversy concerning class actions in Australia has concerned shareholder class actions and how they are funded. This paper consciously changes the focus of its commentary away from such debates and towards examining human rights class actions in Australia. As Australia is the only advanced country without national constitutional or statutory protections of human rights, attempts to legally protect human rights have manifested themselves indirectly in various areas of the law that might not at first glance seem to have much to do with human rights. Class actions has been one of those legal areas. Given the paucity of existing commentary on Australian human rights class actions this paper begins with an examination of the types of cases that have been bought as human rights class actions and provides examples of them. Drawing on literature concerning the effectiveness of actions undertaken to protect human rights and on class actions protecting human rights overseas, it uses publicly available information to undertake a qualitative analysis concerning the effectiveness of such litigation. After coming to some tentative conclusions about such effectiveness, it examines whether US class actions law might be a source of ideas that could be adapted to address any such limitations of effectiveness in the same way that US class actions jurisprudence was originally drawn upon by the Australian Law Reform Commission to recommend that class actions provisions be enacted in Australia. Given the relative absence of legal norms protecting human rights in Australia as well as the relative weakness of social movements seeking greater legal protection for human rights in Australia, the search by human rights advocates for ways to access courts and obtain greater legal furtherance of human rights is a task of some urgency. This paper attempts to contribute to that search as well as to advance the analysis of Australian human rights class actions and their effectiveness more generally.
A review of microplastics pollution and its remediation methods: Current scenario and future aspects
Authors: Sutradhar Manish
Published: June 2022

Global plastic production and its use have been omnipresent since the early 19th century. The disposal of plastics undergoes breakdown due to various physicochemical and biological factors that trigger the formation of microplastics (MPs). Due to their hydrophobic properties, structural stability, and functional groups, it is difficult to degrade in natural habitat. The presence of their large surface area also helps to resist the decay of MPs. This review summarizes the recent trends and development of MPs degradation. The method includes biodegradation, various types of advanced oxidation processes (AOPs) such as photocatalytic oxidation, photo-degradation, and electrochemical oxidation, and also discussed the potential health risk factors of MPs and their degradation products. Most of the methods achieved nearly satisfactory performance that degraded the MPs into CO2, H20, and also secondary microplastic particles with persistent organic pollutants (POPs) under laboratory conditions, which have been studied by various researchers. It is also evident that the degradation of MPs has many challenges, therefore finding a sustainable approach is an urgent need to deal with the issue of global microplastic pollution. Some suggestions have been highlighted such as toxicity detection of remaining MPs particles after degradation, and analysis of secondary metabolites of microbes secreted during bioremediation that may have a negative impact on the environment. The selective and specific implementation of microbes and photo-catalyst that degrade MPs into useful and nontoxic components.
Quantifying drysuit seal pressures in non-immersed scuba divers
Authors:   Department of Anesthesiology, Center for Hyperbaric and Environmental Physiology, Duke University, Durham (NC), USA, Covington Derek B , Spears Matthew ,   Department of Anesthesiology, University of Florida College of Medicine, Gainesville (FL), USA, Wardhan Richa ,   Department of Anesthesiology, University of Florida College of Medicine, Gainesville (FL), USA, Brennan Meghan ,   Department of Anesthesiology, University of Florida College of Medicine, Gainesville (FL), USA, Islam Yasmin ,   Department of Ophthalmology, University of Florida College of Medicine, Gainesville (FL), USA, Pitkin Andrew D ,   Department of Anesthesiology, University of Florida College of Medicine, Gainesville (FL), USA
Published: June 2022

Introduction: Drysuits use flexible neck and wrist seals to maintain water-tight seals. However, if the seals exert too much pressure adverse physiological effects are possible, including dizziness, lightheadedness, syncope, and paresthesias in the hands. We aimed to quantify the seal pressures of neck and wrist seals in non-immersed divers. Methods: We recruited 33 diving volunteers at two dive facilities in High Springs, Florida. After a history and physical exam, we measured vital signs as well as wrist and neck seal pressures using a manometer system. Results: The mean (SD) seal pressure of the right wrist seals was found to be 38.8 (14.9) mmHg, while that of the left wrist seals was 37.6 (14.9) mmHg. The average neck seal pressure was 23.7 (9.4) mmHg. Subgroup analysis of seal material demonstrated higher mean sealing pressure with latex seals compared to silicone; however, this difference was not statistically significant. Conclusions: Drysuit seal pressures are high enough to have vascular implications and even potentially cause peripheral nerve injury at the wrist. Divers should trim their seals appropriately and be vigilant regarding symptoms of excessive seal pressures. Further research may elucidate if seal material influences magnitude of seal pressure.