bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancing Electric Vehicle Range Prediction through Deep Learning: An Autoencoder and Neural Network Approach
Authors: Airlangga Gregorius
Published: September 2024

The burgeoning adoption of electric vehicles (EVs) signifies a pivotal shift towards sustainable transportation, necessitated by the global imperative to mitigate climate change impacts. Central to this transition is the resolution of range anxiety, a significant barrier impeding wider EV acceptance. This research introduces a novel deep learning framework combining autoencoders and deep neural networks (DNNs) to predict EV range more accurately and reliably. Leveraging a comprehensive dataset from the "Electric Vehicle Population Data," we embarked on a meticulous process of data cleaning, feature engineering, and preprocessing to prepare the dataset for analysis. The study innovatively applies an autoencoder for unsupervised feature learning, effectively reducing dimensionality and extracting salient features from high-dimensional EV data. Subsequently, a DNN model utilizes these features to predict the EV range, offering insights into the vehicle's performance across various conditions. Employing a 10-fold cross-validation approach, the model's efficacy is rigorously evaluated, ensuring robustness and generalizability of the predictions. Our methodology demonstrates a significant enhancement in prediction accuracy compared to conventional machine learning models, as evidenced by the Mean Squared Error (MSE) metric. This research not only contributes to the academic discourse on sustainable transportation and deep learning applications but also provides practical insights for manufacturers, policymakers, and consumers aiming to navigate the complexities of EV adoption and infrastructure development. By addressing the critical challenge of range prediction, this study paves the way for advancing EV analytics, ultimately supporting the transition to a more sustainable and efficient transportation ecosystem.
Coffee Type Classification Using Backpropagation Artificial Neural Network
Authors: Adytia Pitrasacha , Wahyuni Wahyuni , Asmaramany Dimas , Sussolaikah Kelik
Published: September 2024

Coffee has several types including robusta coffee, arabica coffee and luwak coffee. Each coffee has certain characteristics of color, texture, aroma and also the quality of the taste. Coffee counterfeiting is also common. This coffee counterfeiting usually uses materials such as corn, wheat, soybeans, husks, sticks and robusta coffee beans. So that a model is needed to be able to classify the type of coffee. This research uses artificial neural network machine learning algorithms to identify and classify coffee. Quality training and testing data is needed in this method because it will affect the final results. Initial data is collected via e-nose, with this equipment data on changes in electrical voltage will be obtained from 4 sensors, namely MQ-2, MQ-3, MQ-7 and MQ-135. These 4 features will be used in the classification process. With 900 sets of training data, the test results show that the neural network is able to provide correct classification 99% of the 3 sets of testing data. The results of training and testing show that the neural network formed can identify and distinguish coffee types with good results.
Forecasting Climate Change Patterns to Improving Rice Harvest Using SVR for Achieving Green Economy
Authors: Juliandy Carles , Kelvin Kelvin , Halim Apriyanto , Pipin Sio Jurnalis , Sinaga Frans Mikael , Lestari Wulan Sri
Published: September 2024

The consistently declining rice harvest will cause several economic and environmental problems. The unstable and unpredictable climate change was believed as the main problem of the declining rice harvest. We proposed a method for forecasting climate change to help the farmer in their rice cultivation. We used Support Vector Regression (SVR) to improve algorithm steps such as normalizing the data and applying an Adaptive Linear Combiner (ALC) to optimize the dataset before we processed it with the algorithm. Our model gets 95% accuracy as measured with the confusion matrix. We believe our model will help the farmers in their rice cultivation with good climate forecasting. A further benefit of this research we belief that with the well-forecasted climate, the usage of pesticides will decrease and will help the vision of the Indonesian government with a green economy
Application of Canny Method to Detect Vehicle License Plate in Tanjung Balai City Government Mess Area
Authors: Aini Siti Nurul , Kurniawan Rakhmat
Published: September 2024

Vehicles have a license plate that serves to be the identity of a vehicle. The shape of the plate is in the form of a piece of metal mounted on the vehicle as an official identity. Making a license plate or Motor Vehicle Number Sign in Indonesia is regulated in Government Regulation No. 60 of 2016 with a validity period of 5 years. The regulation is about the type and tariff of Non-Tax State Revenue (BNBP), and has been officially enacted on January 6, 2017, by replacing Government Regulation No.50 of 2010, quoted from the Kompas newspaper website. Image is one of the components of multimedia that plays an important role because it contains information in visual form. Images have more information that can be conveyed than in the form of text. An image is a collection of image elements (pixels) that as a whole record a scene through a visual sensory (camera). Canny edge detection can detect edges with a minimum error rate, canny edge detection has a difference with other operators because it uses a Gaussian Derivative Kernel that can refine the appearance of the image. Good location can minimize the distance of edge detection produced by processing, so that the location of the edge can be detected similar to the real edge. The accuracy value of applying this method reaches 99.88%-100%. And lastly, one response to single edge that can produce a single edge, not giving false edges.
US-China Rivalry in Health Diplomacy: A Case Study of COVID-19 Vaccine in Latin America
Authors: Azzahra A. Qalbi Faathimah
Published: September 2024

The COVID-19 pandemic has ushered in a new era of rivalry among Great Powers, driven by their pursuit of economic and geopolitical gains amidst the global health crisis. This journal examines the strategies employed by the United States’ reactions to China’s rising power to expand its influence and access new markets through the distribution of COVID-19 vaccines in Latin America. Using J. J. Mearsheimer’s theory of Great Power Rivalry, this study delves into the dynamics of this rivalry, with a particular focus on the Latin American region. The findings reveal that the United States has utilized a combination of balance of power and blackmail tactics to counter China’s growing influence.
Mindfulness-Based Asmaul Husna and changes in general adaptive function response among schizophrenia: A Quasi-experimental study
Authors: Dewi Inggriane Puspita , Haroen Hartiah , Agustina Hanna Rizmadewi , Pahria Tuti , Utomo Shella Febrita Putri , Aisyah Popy Siti , Susanti Icih
Published: September 2024

Background. Poor functional capacity is one of the factors that increase the risk of recurrence of positive and negative symptoms in schizophrenia. Mindfulness is a treatment potentially help patients become fully accepting of their conditions and conscious of it, allowing them to regulate unpleasant emotions and increase awareness of positive emotions.
Methods. This study aimed to investigate effect of mindfulness-based Asmaul Husna on the overall adaptive functioning of individuals with schizophrenia. This quasi-experiment times series study involved 36 participants selected with simple random sampling. The inclusion criteria of participants were adult Muslim with schizophrenia who had a PANSS-EC score <10, mild symptoms, risk of violent behavior. Participants with severe symptoms and complications from other diseases were excluded. Mindfulness-based Asmaul Husna consisted of Musyahadah-witnessing, tassawur-imagination, tafakkur-contemplation, tadabbur-reflection, and muhasabah-self-introspection was given to each participant over five days. A modified-Global Assessment Functioning (m-GAF) scale used to measure participants' general adaptive functional responses before and after intervention including follow-up at the first and second month after the intervention.
Results. There was a significant increase of the m-GAF score (p < 0.001) and a chi-square value of 177.2 after the implementation of mindfulness-based Asmaul Husna intervention. The highest mean score difference was observed at the first and second follow-ups, conducted one and two months after the interventions. The effect size calculated using Kendall’s Wa indicates a significant effect (0.821).
Conclusion. The study suggests there is a positive effect of the mindfulness-based Asmaul Husna intervention on adaptive functioning of people with schizophrenia.
Synthesis, technological prospects and applications of MXene in biomedicine, supercapacitors and sensors: A review
Authors: Badawi M. Nujud , Bhuyan M. , Agrawal Namrata , Kumar Yogesh
Published: September 2024

MXenes are one of the most important classes of materials discussed worldwide by many researchers of diverse fields for diverse applications in recent years. It is a nanomaterial with a wide range of applications due to its multiple forms and structures with fascinating properties, for example, high surface area and porosity, biocompatibility, ease of fictionalizing with various active chemical moieties, benefit of high metallic conductivity, activated metallic hydroxide sites, and sensitivity to moisture. MXenes have great chances for potential applications in environmental issues, water purification, biological applications, and energy storage devices and sensors. MXenes show great selectivity towards the absorption of heavy metals and a good capability to reduce chemical and biological pollutants present in the water. The present review article critically analyzed advancements in water purification using the adsorption and reduction abilities of MXenes and their composites. The mechanism of various procedures, important challenges, and associated problems using MXene and their composites are discussed in detail. The future research directions can be extracted from this article efficiently and comprehensively. The energy storage issues of rechargeable lithium-ion batteries, batteries other than lithium-ion batteries, and electrochemical capacitors are also discussed in detail.
Online dispute resolution mechanism for cross-border e-commerce: Empirical evidence from China
Authors: Zuo Xiangbin , Dahlan Nur Khalidah , Ahamat Haniff
Published: September 2024

With the rapid development of global e-commerce, cross-border e-commerce has become an important force in promoting international trade and economic globalization. Due to the rapid development of cross-border e-commerce, the number of online disputes is gradually increasing. These disputes demonstrate their complexity and diversity in terms of legal application, evidence acquisition, and enforcement. Tmall Global is a cross-border e-commerce platform under the Chinese e-commerce giant Alibaba Group. This study takes Tmall Global as an example to analyze the characteristics of disputes on this platform and explore the current situation of online disputes in cross-border e-commerce. Drawing on the experience of online dispute resolution in the European Union, ASEAN, and other regions, this article proposes a series of suggestions to improve China’s cross-border e-commerce online dispute resolution mechanism, including enhancing the platform’s own dispute resolution capabilities, strengthening international cooperation and artificial intelligence, optimizing dispute resolution processes using large data and cloud computing, strengthening consumer rights protection, and optimizing legal and regulatory frameworks. The aim is to provide an effective dispute resolution mechanism for China’s cross-border e-commerce platforms and provide useful reference for other countries.
Design and practice of human-machine cooperative international Chinese character teaching in ChatGPT application
Authors: Tai Nguyen Phuoc , Dinh Van Thuy
Published: September 2024

The incorporation of artificial intelligence (AI) into language education has created new opportunities for improving the instruction and acquisition of Chinese characters. Nevertheless, the cognitive difficulties linked to the acquisition of Chinese characters, such as their intricate visual features and lack of clear meaning, necessitate thoughtful deliberation when developing AI-supported learning interventions. The objective of this project is to explore the capacity of a collaborative method between humans and machines in teaching Chinese characters, utilising the advantages of both human expertise and AI technology. We specifically investigate the utilisation of ChatGPT, a substantial language model, for the creation of instructional materials and evaluation methods aimed at teaching Chinese characters to individuals who are not native speakers. The study utilises a mixed-methods approach, which involves both qualitative examination of lesson plans created by ChatGPT and quantitative evaluation of student learning outcomes. The results indicate that the suggested framework for human-machine collaboration can successfully tackle the cognitive difficulties associated with learning Chinese characters, resulting in enhanced learner involvement and performance. Nevertheless, the research also emphasises the constraints of AI-generated material and the significance of human involvement in guaranteeing the accuracy and dependability of educational interventions. This research adds to the expanding collection of literature on AI-assisted language learning and offers practical insights for educators and instructional designers who aim to use AI tools into Chinese language curriculum. The results emphasise the necessity of employing a multi-disciplinary strategy in AI-supported language learning, incorporating knowledge from cognitive psychology, educational technology, and second language acquisition.
On the relevance of ideology and electoral cycles in the celebration of public-private partnership contracts for infrastructures in Brazil
Authors: Bertulucci Maria Luísa , Pereira Alfredo Marvão
Published: September 2024

This paper provides a unique empirical analysis of the effects of political factors on the adoption of PPP contracts in Brazil. As such, it innovates along two different lines: first, political factors behind the adoption of PPPs have been largely ignored in the vast body of empirical literature, and second, there is scant work done on the motives of any kind behind the adoption of PPPs in Brazil. Various economic and financial reasons have been evoked to justify the use of PPPs in general. These include the goal of promoting socio-economic development in a tight public budgetary framework or of improving the quality of public services through the use of economically efficient and cost-effective mechanisms. Any possible underlying political motives, however, have been overlooked in the PPP research. And yet, there is abundant literature suggesting a link between the adoption of PPPs and the ideology of the governing body or the political cycles associated with elections. This study examines the impact of ideological commitment and opportunistic political behavior on the process of PPP contracting in Brazil, including the stages of public consultation, the publication of tender, and the signature of the contract, using federative-level data for the period between 2005 and 2022. Consistent with the outstanding literature, the two hypotheses are tested: first, conservative parties tend to celebrate more PPP contracts than left-leaning parties, and second, the electoral calendar has a significant effect in the process, allowing for opportunistic behaviors. Empirical results suggest that there is little evidence for the relevance of ideological leanings in the process of adopting PPPs in Brazil. Additionally, regardless of ideology, parties significantly choose to enter PPPs at specific points in the electoral cycle, suggesting decisions are influenced by political considerations and electoral strategy rather than by purely financial or ideological considerations. This may pose severe constraints on the efficiency and cost-effectiveness of the contracts, negatively impacting public governance and leading to protracted costs for taxpayers.
Econometric forecasting of production matrix by total output in the framework of interindustry balance: Evidence from European firms
Authors: Moiseev Nikita , Savina Natalia , Maksimov Denis , Mikhaylov Alexey , Karpyn Zuleima , Barykin Sergey , An Jaehyung , Senjyu Tomonobu
Published: September 2024

The paper is devoted to testing the core prerequisite of inter-industry balance methodology which states, that intermediate consumption is strictly proportional to the total output of an industry, or, in other words, production matrix is constant over time. The paper uses standard econometric and statistical tools to test the hypothesis of proportionality of intermediate consumption to the total output. The statistical base of the study is the world input-output tables collected for the period from 2000 to 2022 from European firms. By conducting a rigorous empirical analysis, we find that tested prerequisite cannot be considered as valid. We also propose a methodology of point forecasting of production matrices by total output, which helps to make more accurate forecasts compared to the trivial model, when production matrix is assumed to stay unchanged. The proposed methodology is to extend the input-output methodology by introducing the coefficients of proportionality of changes in intermediate consumption and changes in the total output. Proportionality coefficients are proposed to be obtained by regression equations based on statistical data of input-output tables. The results of this work can be useful for executive authorities in planning large state economic projects, as well as in assessing the impact of external shocks on the country's economy.
Multiphase Flow Regime Identification in Cryogenic Nitrogen using Electrical Capacitance Measurement Technology
Authors: Charleston Matthew A. , Straiton Benjamin J. , Marashdeh Qussai M.
Published: September 2024

Understanding and modeling multiphase flow is of vital importance to the design of next-generation cryogenic systems. While many experiments characterizing multiphase flow have been performed on Earth, the behavior of cryogenic systems still needs to be fully described in low gravity and microgravity conditions. As the necessity of cryogenic systems increases for in-space refueling operations, increased heat transfer efficiency, and in-situ resource utilization, the demand for better fluid models, instrumentation, and control systems also increases. In this paper, a capacitance-based flow regime identification algorithm is developed for use with cryogenic systems. Data is collected on a liquid nitrogen system for a wide array of flow regimes in a ½” tube. Quantitative parameters are developed that are able to determine the real-time multiphase flow regime and the algorithm is verified using accepted models, providing much that is needed for the foundation of a multiphase flow regime identification instrument with broad applications in fluid modeling, research, and cryogenic system feedback control.
As tecnologias cerâmicas das estruturas de terra do Acre
Authors: Pessoa Cliverson , Freitas Costa Angislaine , Pessôa Coelho Jane , Frota Raquel , Ferreira Fernando , Cesar Picolli Jaco , Neves Eduardo Góes
Published: September 2024

Este artigo apresenta a cadeia operatória de vasilhas evidenciadas em sítios com estruturas de terra do estado do Acre, Brasil. A proposta é analisar as tecnologias cerâmicas, seus possíveis usos e padrões de descartes, buscando compreender os processos mais amplos de mudanças culturais na região. Esta pesquisa contribui para uma sistematização inicial das etapas de produção das vasilhas e avalia a relevância da Tradição Quinari nesse contexto. Os resultados apontam que uma série de características tecnológicas das cerâmicas encontradas nesses sítios, longe dos grandes rios, convergem para modelos arqueológicos ribeirinhos que explicam a movimentação de grupos, objetos e ideias que dominaram a planície aluvial.
Entre contas e corpos: Crioulização e negociações estéticas em contextos de escravizados do Sudeste, séculos XVIII e XIX
Authors: Brito Patrícia
Published: September 2024

A partir da comparação das contas de vidro presentes em dois sítios de escravizados, as senzalas do Colégio dos Jesuítas de Campos dos Goytacazes e o Cais do Valongo, situados no estado do Rio de Janeiro, busco compreender como africanos e seus descendentes incorporaram esses itens na construção de suas identidades e em suas concepções estéticas, tendo como premissa as teorias que versam sobre as transformações culturais, especialmente no que concerne ao processo de crioulização. Para subsidiar as interpretações, considero, com base em fontes diversas, o trânsito de valores e cosmologias entre a África Central e o Brasil.
Protective antibody concentrations in primary immunodeficiency following infusion with 5% or 10% intravenous immunoglobulin
Authors: Paddick Martyn , Clark Kim , Wolford Eric , More John
Published: September 2024

Background: Inadequate production of immunoglobulin G (IgG) antibodies renders patients with primary immunodeficiency susceptible to infection by numerous pathogens, some of which can lead to severe asthma exacerbation and possible death. These patients who are immunocompromised
are often reliant on intravenous immunoglobulin (IVIG) therapies, which provide passive antibodies against various respiratory pathogens, including measles virus and encapsulated bacteria. Objective: We conducted a subanalysis of data from a multicenter, multinational,
phase III, open-label bioequivalence study to compare protective concentrations of IgG antibodies provided by a 5% and a 10% IVIG product in patients with primary immunodeficiency. Methods: Patients on stable 21- or 28-day regimens of previous IVIG products were assigned
to receive study treatment (adults: 5% IVIG and 10% IVIG; children: 10% IVIG) at doses of 300‐800 mg/kg per infusion. Trough concentrations of total IgG, IgG subclasses, measles-neutralizing antibodies, and IgG against Haemophilus influenzae type b and Streptococcus pneumoniae serotypes
were evaluated. Results: A total of 48 patients (33 adults ages 16‐55 years; 15 children ages 2‐15 years) were enrolled and received treatment. No statistically significant differences in trough concentrations of total IgG, IgG subclasses, measles-neutralizing
antibodies, or IgG directed at encapsulated bacteria were observed between the 5% and 10% formulations in analyses by age (adult or pediatric) or infusion schedule (every 21 or 28 days). All evaluated patients had trough IgG concentrations above accepted thresholds for protection against disease.
Conclusion: These findings support the conclusion that, at dose levels and infusion schedules prescribed in clinical practice, this 5% and 10% IVIG product provided consistent, predictable, and bioequivalent IgG concentrations for adult and pediatric patients with primary immunodeficiency
disease. Both formulations delivered trough antibody concentrations of total IgG, measles-neutralizing antibodies, and antibodies against encapsulated bacteria that are above thresholds accepted as protective.Clinical trial NCT01963143, <ext-link xmlns:xlink="http://www.w3.org/1999/xlink"
ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov">www.clinicaltrials.gov
Consumption of Pasteurized Whole Milk Challenges in Padang, Indonesia: Insights from Consumers and Business Perspectives
Authors: Ratni Eli , Lendrawati
Published: September 2024

This study investigates the challenges and opportunities surrounding the decline in local pasteurized whole dairy milk consumption in Indonesia, focusing on West Sumatra. Despite potential health benefits, factors such as limited availability, storage challenges, and concerns about taste and product quality have hindered the adoption of whole milk as a mixing ingredient in contemporary beverages. Through a survey of beverage outlets in Padang City and analyzing consumer preferences, this research identifies critical barriers businesses face and proposes interventions to address them. These interventions include improving milk accessibility, providing business educational programs, promoting taste and quality benefits, supporting recipe development, conducting market research, and collaborating with suppliers. By addressing these challenges, businesses can expand consumer choice, stimulate demand, and drive growth in the whole milk-based beverage market, ultimately benefiting local dairy farmers and public health in Indonesia.
MANAJAMEN KOMUNIKASI PENGELOLA WISATA EDUKASI SUBAK TEBA MAJELANGU BERBASIS PARIWISATA BERKELANJUTAN
Authors: Bagus Ade Tegar Prabawa
Published: September 2024

The Subak Teba Majelangu Educational Tourism Object is a Subak Educational tourism site offering a variety of activities designed to provide an educational and interactive experience about the subak system. These activities include Agricultural Education, where visitors can learn traditional Balinese farming techniques; the Subak Museum, which presents information and artifacts related to the history and culture of the subak irrigation system; Animal Feeding, which allows visitors to interact directly with domestic animals; the Seed House, where visitors can learn about the seedling process and plant growth; as well as various other activities. To restore and further develop the Subak Teba Majelangu Educational Tourism site, management and implementation involving all parties are required, including not only the government but also the community and stakeholders. The managers of the Subak Teba Majelangu Educational Tourism need to be prepared to grow by building market networks with tourism industry players, developing promotional media, and applying various innovations to revive its tourism potential. The aim of this research is to analyze the Communication Management of the Subak Teba Majelangu Educational Tourism based on Sustainable Tourism. The method used in this research is qualitative with a descriptive analysis type. Subak Teba Majelangu also offers several activities that support recreational and educational activities such as Agricultural Education, Non-Educational Activities, Comparative Study or Study Visits, Outbound Activities and Games, Yoga, and Meetings. Therefore, the development carried out by the Subak Teba Majelangu educational tourism managers includes Defining Public Relations Problems, Planning and Programming, Taking Action and Communication, and Evaluating the Program
O uso da sala de aula invertida para ensinar ciências morfofisiológicas da saúde em uma universidade da Amazônia
Authors: Santos Raniele Romano dos , Domingues Robson José de Souza , Freitas Jofre Jacob da Silva , Miranda José Carlos de
Published: September 2024

Objetivo: Avaliar o uso da sala de aula invertida nas ciências morfofisiológicas da saúde. Métodos: Utilizando como instrumento o método descritivo, com prevalência qualitativa, este estudo, através da transversalidade e com amostra discente de cursos semipresenciais, reflete respostas de um questionário, desenvolvido no segundo semestre de 2023. Resultados: Alunos com idades entre 18 e 43 anos participaram, e foi relatado por uma boa parte dos participantes que os mesmos têm dúvidas quanto a aprendizagem e, quando abordado os conceitos, apresentaram uma percepção inconclusiva. A maioria é favorável ao uso da sala de aula invertida somente após aprendizagem presencial das conceituações morfofisiológicas básicas. Conclusão: Os alunos apresentaram dificuldades em conceituar a sala de aula invertida e boa parte deles tem baixa aceitação da metodologia adotada. Em se tratando do processo formativo dos alunos, eles sugerem que os conceitos morfofisiológicos, sejam abordados de forma presencial nos primeiros períodos da graduação.
Repercussões da pandemia da COVID-19 sobre profissionais atuantes em uma equipe de estratégia de saúde da família
Authors: Amorim Wanderléia Rodrigues de , Marques Maria Suzana
Published: September 2024

Objetivo: Avaliar as repercussões da pandemia da COVID-19 em profissionais da Atenção Primária em Saúde. Métodos: Trata-se de um estudo descritivo, analítico e interpretativo de abordagem qualitativa. Realizou-se entrevista individual semiestruturada e aplicação de questionário sociodemográfico com profissionais atuantes em uma unidade de Estratégia de Saúde da Família em um município de Minas Gerais. Foram entrevistados ao todo 16 profissionais, sendo 4 do sexo masculino e 12 do sexo feminino, cuja média de tempo de atuação na APS foi de 9,7 anos. Resultados: A análise dos resultados mostra que na fase inicial da pandemia, os sentimentos predominantes dos profissionais de saúde estudados foram ansiedade e medo da auto contaminação e disseminação do vírus. Do ponto de vista profissional, o isolamento, a adaptação ao uso de EPIs e a higienização das mãos configuraram o principal desafio para os participantes. À época da realização deste estudo, houve aumento das percepções positivas acerca da evolução da pandemia da COVID-19, sobretudo associadas à vacinação e à facilidade do acesso aos EPIs. Conclusão: Apesar da reduzida amostra, a pesquisa abrange a individualidade dos profissionais e favorece a pluralidade de resultados. Conclui-se, portanto, que a pandemia da COVID-19 teve influência sobre a saúde física e psíquica dos profissionais.
Perfil clínico epidemiológico dos pacientes com tumor intracraniano
Authors: Borssoi Samara Regina , Borssoi Anieli Sabrina , Rauber Rafael
Published: September 2024

Objetivo: Compreender o perfil dos pacientes submetidos a radiocirurgia para a ressecção de tumores intracranianos em um hospital referência no tratamento de câncer no oeste paranaense nos últimos 10 anos. Métodos: Trata-se de um estudo observacional, transversal que analisou 33 prontuários eletrônicos de pacientes com tumores intracranianos submetidos a radiocirurgia entre 2013 e 2023 no hospital em questão. Resultados: Identificou-se majoritariamente pacientes do sexo feminino (57,6%), com idade média de 55 anos. Lesões metastáticas foram mais prevalentes (66,6%), sendo mama e pulmão os sítios tumorais primários mais encontrados. Quanto ao número de lesões intracranianas apresentadas, a maioria dos pacientes apresentavam apenas uma lesão intracraniana (78,8%). Dentre os pacientes estudados, em 72,7% dos casos, a radiocirurgia foi utilizada para a ressecção da lesão, sendo minoritariamente utilizada em leito cirúrgico. Por fim, contatou-se a predileção por radiocirurgia fracionada (69,8%), em média 5 doses de 5Gy cada. Conclusão: O perfil encontrado foi o de mulheres de meia-idade, portadoras de apenas uma lesão intracraniana metastática, tratadas com radiocirurgia fracionada, estando em conformidade com o encontrado na literatura. Propõe-se a realização de mais estudos de forma fragmentada para compreender melhor os dados aqui expostos.
Perfil lipídico de pessoas vivendo com HIV/AIDS em uso de terapia antirretroviral e com dislipidemia
Authors: Farias Larissa dos Reis , Miranda Letícia Vitória Garcia , Araújo Daeny Nunes de , Lopes Jayne Antoniele Miranda , Bezerra Luany Batista , Mendonça Flávia Silva , Sampaio Luís Filipe de Castro , Braga Rebeca Lima , Dantas Thalita Bandeira , Libonati Rosana Maria Feio
Published: September 2024

Objetivo: Analisar a evolução do perfil lipídico e os fatores de risco associados em pacientes com dislipidemia e uso de Terapia Antirretroviral para melhor manejo clínico dos pacientes. Métodos: Estudo descritivo, longitudinal em pessoas vivendo com HIV/AIDS e em uso regular de TARV com diagnóstico de dislipidemia, avaliando hábitos de vida e critérios para síndrome metabólica. Resultados: Cinquenta e oito pacientes foram avaliados sendo a distribuição entre sexo masculino e feminino equivalente, média de idade 58,1 anos e tempo médio de infecção pelo vírus de 15,68 anos, sendo o máximo 32 anos. O tempo médio de uso de TARV foi de 14,94 anos, sendo prevalente o uso de Inibidores de Protease. Observou-se que houve aumento no HDL-colesterol e uma diminuição no LDL-colesterol, colesterol total e triglicerídeos. Ao analisar as comorbidades relacionados ao quadro, 77,5% apresentavam síndrome metabólica pelos critérios do IDF, 43% tinham diagnóstico de hipertensão arterial e 73,6% diabetes. Todos os pacientes faziam uso de hipolipemiantes. Conclusão: Foi observado melhora no perfil lipídico, no entanto, a exposição a múltiplos fatores comportamentais e de saúde, impactam no controle endócrino-metabólico.
Anemia de Fanconi, as diferentes manifestações clínicas entre dois irmãos: relato de caso
Authors: Godinho Ariadne Carvalho , Melo Mikaela Raiane Nunes , Bedin Paola , Oliveira Hemilly Joanny Cardoso de , Fávero Ana Júlia dal Ponte , Coelho Fernanda Alves Martins , Oliveira Gustavo Cruz de , Queiroz Andréa Delmare Bomfim de , Oliveira Lindberg Jesuino de , Emerenciano Luiza Magalhães
Published: September 2024

Objetivo: Relatar as principais diferenças das manifestações clínicas da Anemia de Fanconi (AF) entre dois irmãos. Detalhamento de caso: Paciente AMS, 02 anos de idade histórico de internamento em unidade semi-intensiva de neonatologia em decorrência de correção de atresia de esôfago, fístula traqueoesofágica e luxação congênita de quadril. Solicitada a realização de sequenciamento completo do genoma para a paciente e, no resultado foi encontrada uma variante patogênica que definiu o diagnóstico molecular associado ao quadro clínico, em homozigose, no gene FANCG, que foi classificada como patogênica. Paciente LRMS, 4 anos, sexo masculino, sem histórico comórbido. Realizada biópsia medular que evidenciou medula óssea hipocelular para a idade, com redução da maturação de todas as séries associadas e alterações citoarquiteturais, sugestivo de aplasia de medula. Pesquisa de clone NPH ausente. Realizado DEB test com pesquisa em 25 células, evidenciando 5 quebras espontâneas, sugerindo AF. Considerações finais: A identificação e o conhecimento do perfil clínico e genético de pacientes brasileiros diagnosticados com AF possibilita a investigação de diferentes fenótipos e a influência de genótipos no curso clínico da patologia.
Significance of repertory in homoeopathic curriculum
Authors: AR Munir
Published: September 2024

Deciding on homoeopathic prescriptions involves a complex process of harmonising the pathognomonic expressions of the patient and the pathogenetic expression of a drug during its trials based on homoeopathic principles. The complexity is accentuated by the multiple layers of patient expressions and their differentiated harmonisation with the drug data. Repertory is a decisional tool invented and improvised over numerous attempts to assist in the prescription decision. However, the most visible use of repertory has been as a tool to match the symptoms. The emerging field of decision-making offers new insight into reinventing the philosophy of repertory as an evidence-based decision-assisting tool. There is a need to conflate the philosophy of repertorisation with the evidence-based decision process and introduce this into the curriculum of homoeopathic academic programs.
Lichen planus an autoimmune disease treated using Homoeopathic medicine – An evidence-based case report
Authors: Afroza Tamara , Kabiraj Kalyan , Pramanik Pratima , Parveen Shaista
Published: September 2024

Lichen planus (LP) is an immunological reaction to a pathogen located in the basal cell layer of the epidermis. It mainly affects the adult population. LP can be better approached constitutionally by considering the totality of symptoms. A 56-year-old woman sought Homoeopathic treatment for purple-red, itchy, flat-topped, papular skin lesions on multiple body sites as she hoped to avoid steroid use and excessive medication. The case was taken, and the Homoeopathic medicine was prescribed on the basis of the totality of symptoms. After receiving treatment for 6 months, all skin lesions disappeared, and her general health improved considerably. No further skin lesions occurred in the next 2 years of follow-up. This case illustrates how Homoeopathic medicine can successfully be used to treat a skin disease through individualised treatment.
Prevalence of gastroesophageal reflux disease in Russia: a meta-analysis of population-based studies
Authors: Andreev Dmitry N. , Maev Igor V. , Bordin Dmitry S. , Abdulkhakov Sayar R. , Shaburov Rafik I. , Sokolov Philipp S.
Published: September 2024

Aim. To systematize data on the prevalence of gastroesophageal reflux disease (GERD) in the adult population of Russia.
Materials and methods. The search for studies was conducted in the electronic databases MEDLINE/PubMed, EMBASE, and RSCI (Russian Science Citation Index) from January 2000 to December 2022. The review included relevant publications in peer-reviewed periodicals in English or Russian, publications with data from cross-sectional epidemiological studies assessing the prevalence of GERD in the Russian population, studies on adult patients with GERD, and publications with detailed descriptive statistics that allow using the data in the meta-analysis.
Results. The final analysis included 6 studies involving 34,192 subjects. The overall prevalence of GERD (prevalence of heartburn ± regurgitation once a week or more frequently) in the analyzed studies was 25.605% (95% confidence interval [CI] 17.913–34.147). The analysis used a random effect model, as there was significant heterogeneity between the results in both groups (I2=99.63%; p0.0001). The overall mean age of GERD patients in the study population was 48.14 (95% CI 32.25–4.03) years. The prevalence of GERD in the male population was 23.653% (95% CI 13.351–35.832) and 25.457% (95% CI 17.094–34.849) in females.
Conclusion. This meta-analysis demonstrated that GERD is a common esophageal disease in the Russian population, affecting approximately one in four country residents.
Ferritin as a biomarker of aging: geroprotective peptides of standardized human placental hydrolysate. A review
Authors: Gromova Olga A. , Torshin Ivan Iu. , Chuchalin Alexander G.
Published: September 2024

Ferritin, an iron transport protein, is an acute phase protein of inflammation and oxidative stress (OS), a biomarker of cytolysis and ferroptosis. Inflammation, OS and iron overload are characteristic processes of the pathophysiology of aging. Human placental hydrolysates (HPHs) are promising hepatoprotective agents for anti-aging therapy. The goal of the team of authors was to systematize data on ferritin as a marker of aging and to identify peptides that counteract the aging pathophysiology, including through the regulation of iron and ferritin metabolism, in the HPH Laennec (manufactured by Japan Bioproducts). The results of basic and clinical studies confirm the above relationships and indicate that blood ferritin levels characterize the chronological and biological aging of the human body.
Detection of anticoagulant medication errors by triggers
Authors: Otdelenov Vitaly A. , Kleymenova Elena B. , Nigmatkulova Maria D. , Payushchik Svetlana A. , Dukhanina Olga D. , Yashina Liubov P. , Sychev Dmitry A.
Published: September 2024

Background. Medication errors can cause preventable adverse events. For example, inappropriate use of anticoagulants (AC) can result in bleeding and thromboembolic complications. Detection and analysis of AC medication errors allow to reveal deficiencies in the safety systems in healthcare organizations.
Aim. The study was aimed to develop a method of systematic detection of anticoagulant medication errors for consequent audit, analysis and development of medication safety improvement measures.
Materials and methods. The study was conducted in the multidisciplinary hospital and included 4924 patients admitted from January 2019 to December 2021 who received AC. Three laboratory triggers (international normalized ratio ≥4, serum creatinine ≥133 μmol/l, and glomerulofiltration rate 30 ml/min/1.73 m2) helped to reveal 4304 cases. Their matching with patient’s data helped to develop combined triggers. Two clinical pharmacologists reviewed all cases identified by combined triggers for checking medication errors. The trigger was considered positive when anticoagulant medication error was detected in the history selected by combined trigger.
Results. Of the 4924 patients 253 (5.3%) were selected by combined triggers. Combined trigger allowed to reduce the amount of medical health records audit by 97.3%. Medication errors were detected in 137 patients. Positive predictive value of selected combined triggers varied from 0 to 63.9%. Aggregated positive predictive value of all combined triggers amounted to 54.2%. AC medication errors were detected in 2.8% patients.
Conclusion. Method of systematic detection of AC medication errors using combined triggers in all hospitalized patients receiving AC allowed to reveal typical medication errors for consequent analysis and elaboration of measures to reduce preventable patient harm in healthcare settings.
Clinical, endoscopic, laboratory and immunomorphological parameters in predicting the occurrence of colorectal cancer in patients with diverticular disease of the colon
Authors: Svistunov Andrey А. , Osadchuk Mikhail A. , Mironova Ekaterina D. , Krylova Iuliia S.
Published: September 2024

Aim. To define the role of clinical, endoscopic, laboratory and immunomorphological parameters in predicting the occurrence and course of colorectal cancer (CRC) in patients with diverticular disease of the colon (DDC).
Materials and methods. One hundred and seventy five people with DDC were examined, divided into 3 groups: group 1 – 85 patients with DDC; group 2 – 45 with DDC in combination with adenomatous polyps (AP); 3rd group – 45 with DDC with established CRC (I or II stage). The control group consisted of 30 practically healthy people. Patients and healthy people were examined according to a single program: clinical, laboratory, instrumental data and immunomorphological research methods [use of primary antibodies to p53 (mAb clone DO-7 product no. PA0057, Leica Biosystems, Leica Bond III) and Ki-67 (Ab16667, Abcam, UK)].
Results. Among the main complaints in patients with DDC and CRC, constipation was more common than in patients with DDC and DDC with AP (p0.05). In patients with DDC and colorectal neoplasia, a positive reaction to occult blood in the feces was more often verified, compared with the group with DDC (p0.05). Higher levels of glucose and cholesterol in blood plasma, as well as body mass index were found in patients with DDC with AP and CRC, compared with the DDC group (p0.05). A higher level of expression of Ki-67 and p53 was found in patients with DDC combined with AP and CRC, compared with patients with DDC without colorectal neoplasia (p0.05). At the same time, in patients with DDC with CRC, the expression level of Ki-67 and p53 was higher than in patients with DDC with AP (p0.05)
Conclusion. In patients with DDC combined with AP and CRC, higher levels of glucose, plasma cholesterol, as well as body mass index were observed compared to the group of patients with DDC alone (p0.05). Of note, the results of the determination of Ki-67 and p53 in the mucous membrane of the colon should be considered important prognostic markers for the development of CRC in patients with DDC.
Comparative assessment of the clinical effectiveness of direct-acting antiviral drugs in outpatient patients with acute respiratory viral infections
Authors: Kozlov Konstantin V. , Maltsev Oleg V. , Kasyanenko Kristina V. , Sukachev Vitalii S. , Lyashenko Yuri I. , Kosuhina Anastasia A.
Published: September 2024

Aim. To evaluate the clinical effectiveness, safety and compare the incidence of hospitalization during treatment with antiviral drugs with a direct mechanism of action (riamilovir and umifenovir) in people with acute respiratory viral infections (ARVI) in an outpatient setting.
Materials and methods. The study included 150 outpatients with ARVI aged 18–27 years: 50 patients received riamilovir 250 mg 3 times a day for 5 days, the second group included 50 patients who received umifenovir 200 mg 4 times a day for 5 days, 50 individuals received only pathogenetic treatment.
Results. The use of direct-acting antiviral drugs was characterized by the least severity of pain and aches in the body, general weakness, and in the group of patients receiving riamilovir, the lowest severity of rhinitis, cough, and the lowest morning body temperature were recorded compared to other groups. In riamilovir group reduction in the duration of the disease was observed. The lowest frequency of ARVI pathogens detection was observed on the 6th day in riamilovir group. Outpatient treatment with riamilovir was accompanied by a minimal number of cases of the disease requiring hospitalization.
Conclusion. The use of direct antiviral drugs contributes to the rapid relief of ARVI symptoms in patients receiving medical care on an outpatient basis. The antiviral drug riamilovir showed the most pronounced effectiveness (clinical and laboratory).
Clinical and economic analysis of the use of dapagliflozin in patients with chronic heart failure with reduced left ventricular ejection fraction in various subgroups of standard therapy in the Russian Federation
Authors: Nedogoda Sergey V. , Zhuravleva Marina V. , Tereshchenko Sergey N. , Salasyuk Alla S. , Zhirov Igor V. , Barykina Irina N. , Lutova Viktoria O. , Popova Ekaterina A.
Published: September 2024

Aim. To evaluate the clinical and economic effectiveness of dapagliflozin in patients with chronic heart failure (CHF) with reduced left ventricular ejection fraction (HFrEF) in the Russian Federation in various subgroups of standard therapy for CHF.
Materials and methods. A clinical and economic analysis of the use of the drug dapagliflozin in addition to standard therapy was carried out in comparison with standard therapy in various subgroups of standard therapy for HFrEF using a modeling method. Cost calculations were carried out in a mathematical model adapted to the healthcare conditions of the Russian Federation by using Russian cost indicators and characteristics of the patient population.
Results. The present study demonstrates that the addition of dapagliflozin is beneficial in terms of clinical and cost-effectiveness, regardless of the initial regimen (angiotensin receptor-neprilysin inhibitors [ARNI] or angiotensin-converting enzyme inhibitors [ACEi]/angiotensin II receptor blockers [ARB]) of standard drug therapy for HFrEF and in all cases leads to an increase in life expectancy, a decrease in the number of hospitalizations and emergency visits due to CHF, as well as cardiovascular mortality. The obtained values of added value per additional year of life in all cases are significantly lower than the willingness-to-pay threshold, which indicates the clinical and economic effectiveness of the strategy of prescribing dapagliflozin as part of standard therapy for patients with HFrEF. In the case of adding dapagliflozin the values of the additional cost of an added year of life in the 3 considered standard therapy options (ARNI or ACEi/ARB, only ACEi/ARB and only ARNI) were 291,256, 279,571 and 338,374 rubles respectively. Thus, the scenario of using dapagliflozin with standard therapy, which included only ACEi/ARB, is characterized by the lowest additional cost and has the best clinical and economic characteristics. At the same time the scenario of use with standard therapy, which included only ARNI, is characterized by the highest value of the additional value of the added year of life.