bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunoinformatic design of a COVID-19 subunit vaccine using entire structural immunogenic epitopes of SARS-CoV-2
Authors: Behmard Esmaeil , Soleymani Bijan , Najafi Ali , Barzegari Ebrahim
Published: May 2020

Coronavirus disease-19 (COVID-19) is an acute resolved disease, with estimated 3.4% case fatality rate. Due to insufficient data and short onset time of the disease, researchers have to change the strategy against its associated virus, SARS-CoV-2. One of these strategies is the use of computational methods in the field of drug and vaccine design, which can greatly reduce the time and cost of the therapeutic or immunogenic development projects. In this study, we employed various immunoinformatics tools to design a multi-epitope vaccine polypeptide with the highest potential for activating the human immune system against SARS-CoV-2. The initial epitope set was extracted from the whole set of viral structural proteins. Their potential non-toxic and non-allergenic T- cell and B-cell binding and cytokine inducing epitopes were then identified through a priori immunoinformatic prediction. Selected epitopes were bonded to each other with appropriate links. A suitable adjuvant was added to the N-terminus of the vaccine polypeptide sequence to increase its immunogenicity. Molecular modelling of the 3D structure of the vaccine polypeptide, docking, molecular dynamics simulations and free energy calculations confirmed that the designed vaccine had high affinity for Toll-like receptor 3 binding, and that the vaccine-receptor complex was highly stable. Therefore, the designed polypeptide is promising for antigenicity and inducing an effective and safe immune response against SARS-CoV-2 inside the human body.
A CRIAÇÃO DO VÍNCULO SOCIOAFETIVO COM O RECÉM-NASCIDO: AS DISPARIDADES ENTRE AS LICENÇAS OFERECIDAS AOS PAIS E A IMPORTÂNCIA DOS LAÇOS AFETIVOS
Authors: TORRES Felipe Queiroz
Published: May 2020

O objetivo geral do presente trabalho é enaltecer a proteção à maternidade, ao analisar os institutos da licença-maternidade e paternidade, salientando a importância dos laços afetivos na vida do recém-nascido. O problema resumiu-se em apresentar a insuficiência dos institutos previstos na Constituição Federal, dando ênfase na disparidade dos prazos garantidos aos pais, o que acarreta no acúmulo dos cuidados da criança em somente um dos pais. O presente trabalho propõe-se a demonstrar a importância do afeto nas relações familiares, enfatizando a necessidade da presença de ambos os pais no início da vida de uma criança, sendo que para estabelecer vínculo afetivo familiar, é necessário a disposição de tempo, suprindo as necessidades físicas, mentais e emocionais do bebê. Faz-se uma análise do afeto e do desenvolvimento infantil na Psicanálise, tornando clara a importância do afeto no começo da vida de uma criança, sendo que a sua falta prejudica diretamente o desenvolvimento mental e emocional do recém-nascido. A proteção à maternidade deve ser sempre valorizada, sendo assim, amparado pelo Direito do Trabalho e pelo Direito de Família, faz-se necessário enaltecer os princípios da dignidade da pessoa humana e da afetividade, que valorizam à maternidade e a entidade familiar, garantindo ao recém-nascimento um tratamento justo e destacando a importância do afeto.
OFICINAS DE PARENTALIDADE: EFICIÊNCIA E EFICÁCIA NA ATENUAÇÃO DO FENÔMENO DA ALIENAÇÃO PARENTAL
Authors: BORINI Júlia Tuzzi , CARVALHO Roberta Santos Pereira de
Published: May 2020

As oficinas de parentalidade são encontros realizados com pais em processo de divórcio litigioso, seus filhos, psicólogos, conciliadores e mediadores do CEJUSC. O objetivo principal é amenizar o número de casos de alienação parental. Os pais são instruídos sobre as consequências psicológicas de atitudes alienadoras e, as crianças, sobre os sinais indicadores de pais alienantes, bem como sobre as atitudes a serem tomadas nesses casos. Sem apoio financeiro, as oficinas, hoje, não possuem forças para grande expansão. A presente pesquisa visa analisar a eficiência e a eficácia das oficinas de parentalidade, de forma a apontar a relevância da expansão do projeto.
A PROTEÇÃO AO TRABALHO DA MULHER E A REFORMA TRABALHISTA (LEI Nº 13.467/17)
Authors: SAIA Julia Pereira , ÁGUILA Iara Marthos
Published: May 2020

O objetivo principal do presente trabalho é dissertar acerca dos fundamentos de proteção ao trabalho da mulher e das consequências das mudanças realizadas pela Reforma Trabalhista-Lei nº 13.467/17 em relação a proteção ao trabalho da mulher. Após a promulgação da Constituição Federal de 1988, foi inserido na Consolidação das Leis do Trabalho-CLT o Título III, nomeado "Da Proteção do Trabalho da Mulher", destinado não só a proteger o trabalho da mulher, mas também a assegurar seus direitos em situações específicas.Com a entrada em vigor da Lei nº 13.467/17, que ficou conhecida como Reforma Trabalhista, a CLT sofreu diversas alterações, que ainda geram muitas dúvidas. Uma dessas dúvidas está relacionada a real efetividade do capítulo dedicado a proteção do trabalho da mulher na CLT após a Reforma. Dentre as principais alterações promovidas pela Reforma na CLT, no que tange ao trabalho da mulher, estão o trabalho das gestantes e lactantes em ambientes insalubres, a possibilidade do acordo individual quanto aos intervalos de amamentação e a revogação do art. 384, que previa um descanso obrigatório antes do início do período extraordinário do trabalho.
AS VIOLAÇÕES AO PRINCÍPIO DA DIGNIDADE HUMANA DAS MULHERES ENCARCERADAS E SUAS CRIANÇAS NO BRASIL
Authors: ZUCOLOTTO Camila Ferreira
Published: May 2020

A presente pesquisa científica se insere nas áreas de Direito Constitucional e Direito Penal, com o intuito de abordar, de forma específica, a condição da mulher encarcerada enquanto mãe, e a falha do Estado em cumprir seu papel de interventor e garantidor da dignidade humana nesses casos. A proposta é demonstrar, inicialmente, como o sistema carcerário brasileiro foi originado e desenvolvido até a atualidade, para acolher o gênero feminino e suas necessidades específicas. Além disso, destaca-se os conceitos de dignidade da pessoa humana, e como a legislação se desenvolve em relação à vivência desse grupo específico de pessoas, principalmente com a decisão que aprovou o Habeas Corpus Coletivo tratado na pesquisa, que permitiu que mulheres gestantes ou com filhos menores de doze anos em prisão preventiva pudessem ter sua condição prisional convertida em domiciliar. Dito isto, o projeto foi elaborado de forma a revelar como a lei e a jurisprudência quanto ao assunto se divergem da prática e do dia a dia dessas mulheres. Esse estudo foi feito através de pesquisas históricas, e da leitura de doutrinas atuais de Direito Penal. Tal pesquisa foi realizada pelo intermédio de livros, revistas, textos normativos e artigos científicos, buscando a conexão com a realidade encontrada nas prisões femininas brasileiras. Assim, como resultado, nota-se que o conhecimento histórico e jurídico quanto ao assunto é de extrema importância para que seja discorrido, não apenas formalmente, mas também de forma a abordar socialmente uma problemática atual e de crescente relevância.
Characteristics of certain drugs with antioxidant activity and their use in tuberculosis treatment
Authors: Shovkun L. A. , Kudlay D. A. , Nikolenko N. Yu. , Kampos E. D.
Published: May 2020

The review presents methods for management of free radical reactions in pulmonary tuberculosis patients which are of great importance for relief of clinical symptoms, pathomorphological changes, and the outcome of the disease. It describes the effect of various antioxidant drugs on the course of tissue inflammatory reaction and the development of destructive changes in the lungs.
Geoscience Meets Biology: Raman Spectroscopy in Geobiology and Biomineralization
Authors: Steele Andrew , Fries Marc D. , Pasteris Jill D.
Published: May 2020

Geobiologists attempt to answer such questions as: when and under what conditions did life begin, how can we verify biogenicity in the geologic record, and what governs the relation between the living world and the mineral world? Raman spectroscopy can characterize and identify both organic and inorganic phases, typically nondestructively, at the (sub-)micrometer scale and, thereby, can provide key information to tackle these questions. This article illustrates contributions that Raman spectroscopy has made to understanding mineralization processes in mollusks, corals, and bones. Raman spectroscopy can also be used in the search for earliest terrestrial life and life on other planets. Some challenges for the three Raman instruments to be deployed on Mars are discussed.
ISO 29110 en Colombia: de la teoría a la práctica
Authors: Ordoñez Hugo Armando , Cobos Carlos
Published: May 2020

Las empresas desarrolladoras de software muy pequeñas o Very Small Entities (VSE), con menos de 25 empleados, se ven obligadas a garantizar la calidad del proceso para disminuir el reproceso e incrementar sus ganancias. Esto implica cumplir con buenas prácticas recomendadas en diversos estándares internacionales que ofrecen pautas para mejorar los procesos y productos de software. Sin embargo, los requisitos de estos estándares son difíciles de cumplir para las VSE por su capacidad y los costos de implementación. Este documento describe el proceso de implementaciones de la norma ISO 29110 en el contexto específico de la región del Valle del Cauca en Colombia para 4 empresas, exponiendo las buenas prácticas, herramientas y técnicas utilizadas, de lo cual los resultados son prometedores.
Analysis of traveling wave based fault location method for distribution network with image processing
Authors: Kong Biguang , Liu Baiyang , Liu Xiaoxin , Pu Bicai , Feng Jianhui , Zeng Xiangjun
Published: May 2020

Laws of traveling wave data related to fault location for medium voltage distribution network are discussed and summarized. Given the tree structure of a distribution network, an image of nodes voltage is created combining the use of real-time traveling wave meters at all nodes of the tree. The novelty of this paper is that travelling wavefront are analyzed based on the dynamic changes of these images. Based on principle of the traditional fault location with traveling wave-based method for transmission networks, traveling wave data of fault location for medium voltage distribution networks are plotted in order to estimate propagation velocity and distance between the fault position and the reference node. The results indicate that taking advantage of the laws of data related to first wave front can improve the reliability of the fault location for medium voltage networks.
Control and remediation methods for eutrophic lakes in the past 30 years
Authors: Zhang Yuan , Luo Pingping , Zhao Shuangfeng , Kang Shuxin , Wang Pengbo , Zhou Meimei , Lyu Jiqiang
Published: May 2020

Accelerated eutrophication, which is harmful and difficult to repair, is one of the most obvious and pervasive water pollution problems in the world. In the past three decades, the management of eutrophication has undergone a transformation from simple directed algal killing, reducing endogenous nutrient concentration to multiple technologies for the restoration of lake ecosystems. This article describes the development and revolution of three remediation methods in application, namely physical, chemical, and biological methods, and it outlines their possible improvements and future directions. Physical and chemical methods have obvious and quick effects to purify water in the short term and are more suitable for small-scale lakes. However, these two methods cannot fundamentally solve the eutrophic water phenomenon due to costly and incomplete removal results. Without a sound treatment system, the chemical method easily produces secondary pollution and residues and is usually used for emergency situations. The biological method is cost-effective and sustainable, but needs a long-term period. A combination of these three management techniques can be used to synthesize short-term and long-term management strategies that control current cyanobacterial blooms and restore the ecosystem. In addition, the development and application of new technologies, such as big data and machine learning, are promising approaches.
Macroinvertebrates associated with artificial floating islands installed in River Kshipra for water quality improvement
Authors: Prashant  , Billore Suresh Kumar
Published: May 2020

Artificial floating islands (AFIs) are artificial buoyant superstructures vegetated with riparian plant species, especially reed grass (Phragmites karka) floating on waterscape. These structures are mostly installed in lakes and stagnant systems as a green technology for water quality improvement. In the present study, an AFI was installed in the River Kshipra, Ujjain city at a point where wastewater nullah meets the river. The focus was to study the composition of macroinvertebrates associated with AFIs and to monitor AFIs' role in river water quality improvement. The inspection indicated that the coir-based AFIs' substratum supports a variety of macroinvertebrates that are supplementing the role of AFIs for water quality improvement, besides the role of riparian plants. The open river water, far from AFIs, does not support macroinvertebrates in the upper layer of the water column. The installation of AFIs improved the underneath water quality: reducing the pollution load by 46% of total suspended solids (TSS), 51% of turbidity, 37% of total Kjeldahl nitrogen (TKN) and 39% of biochemical oxygen demand (BOD). The AFIs resulted into a development of a floating habitat for diversity of a macroinvertebrates community of predators, filtering collectors, gathering collectors, scrapers and shredders. The AFIs serves a dual purpose: water cleansing green landscape and additional floating niches for aquatic macroinvertebrates.
Türkçe Dersi Öğretim Programındaki Kök Değerler Çerçevesinde Aytül Akal Masallarının İncelenmesi
Authors: Özbaşı Sevgen
Published: May 2020

Bilişsel, duyuşsal, dilsel, toplumsal gelişim ve kişilik
gelişiminin sağlıklı bir biçimde ilerleyebilmesi ve insanın “birey” olarak
kendini ifade edebilmesi için çocukluk döneminde gereksinimlerine uygun
nitelikte uyaranlarla etkileşimde bulunması gerekir. Çocuğun toplumsallaşma
sürecinde farklı yaşam deneyimlerine tanıklık etmesi onun dilsel, bilişsel
sosyal becerilerinin gelişmesinde yardımcıdır. Bu süreç çocuğun, evrensel ve
ulusal değerleri özümseyip duyarlık ve değerler eğitimi kazanması açısından
önemlidir. Bu noktada, çocuğa yardımcı olabilecek en temel ve en etkili araçlar
çocuk edebiyatı ürünleridir. Benlik gelişimi, duyarlık ve değerler eğitiminin
temellerinin atıldığı okulöncesi dönemlerde, çocuklar için hazırlanan
yapıtların niteliği daha da önem taşımaktadır. Bu dönemde çocukların daha çok
ilgi gösterdiği kitapların masal kitapları olmasından dolayı bu çalışmada Aytül
Akal tarafından yazılan çağdaş masallar, Türkçe Dersi Öğretim Programında
belirtilen “kök değerler” çerçevesinde irdelenmiştir. Betimsel nitelik taşıyan
bu çalışmada veriler doküman incelemesi yoluyla toplanmıştır. İnceleme
sonucunda masalların “adalet, dostluk, dürüstlük, özdenetim, sabır, saygı,
sevgi, sorumluluk, vatanseverlik, yardımseverlik” kök değerlerinin tamamını
içerdiği belirlenmiştir. Bu bağlamda yazarın masallarına yönelik Türkçe Dersi
Öğretim Programında yer alan kök değerleri aktaran ileti ve örnekler
içerdiği;  bu değerler aracılığıyla
çocukların değerler eğitimi sürecine katkı sağlayabileceği söylenebilir.
Emerging Evidence for Neuropsycho-Consequences of COVID-19
Authors: Li Jingwen , Long Xi , Zhang Qing , Fang Xi , Fang Fang , Lv Xuefei , Zhang Dandan , Sun Yu , Li Na , Hu Shaoping , Lin Zhicheng , Xiong Nian
Published: May 2020

:

The pandemic novel coronavirus disease (COVID-19) has become a global concern in
which the respiratory system is not the only one involved. Previous researches have presented the
common clinical manifestations including respiratory symptoms (i.e., fever and cough), fatigue and
myalgia. However, there is limited evidence for neurological and psychological influences of
SARS-CoV-2. In this review, we discuss the common neurological manifestations of COVID-19
including acute cerebrovascular disease (i.e., cerebral hemorrhage) and muscle ache. Possible viral
transmission to the nervous system may occur via circulation, an upper nasal transcribrial route
and/or conjunctival route. Moreover, we cannot ignore the psychological influence on the public,
medical staff and confirmed patients. Dealing with public psychological barriers and performing
psychological crisis intervention are an important part of public health interventions.
Surface Modification of Graphene and its Derivatives for Drug Delivery Systems
Authors: Jonoush Zahra A. , Farahani Masoumeh , Bohlouli Mahboubeh , Niknam Zahra , Golchin Ali , Hatamie Shadie , Rezaei-Tavirani Mostafa , Omidi Meisam , Zali Hakimeh
Published: May 2020

Nowadays, carbon-based nanostructure materials are regarded as promising carriers for
drug delivery to improve the effective treatment of diseases. The formation of covalent and noncovalent
molecular bonds can be used for surface modification of nano-carriers in order to manipulate
their toxicity, water solubility, and cellular internalization. Graphene and its derivatives have
shown important potential in drug delivery systems. Among different graphene derivatives, Graphene
Oxide (GO) is the most extensively used derivative. GO sheets have possessed certain oxygen
functional groups including carboxylic acid groups at the edges, epoxy and hydroxyl groups on the
basal planes. The oxygen groups on the surface of GO sheets enhance their capabilities for functionalization
with chemical and bioactive molecules. In this review, we highlight the recent researches
about the effect of reactive sites on the surface of GO and its derivatives in drug delivery systems.
Therefore, the application of GO and its derivatives have been discussed as a delivery system in cancer
treatment, gene therapy, and combination therapy, followed by discussions on their related issues.
Finally, the review will provide a future perspective to the applications of GO-based materials as part
of drug delivery systems, and may open up new viewpoints to motivate broader interests across these
interdisciplinary fields.
Enzyme Replacement Therapy may Affect Blood Immunosuppressant Monitoring
Authors: Gönel Ataman , Koyuncu Ismail , Bayraktar Nihayet , Tayman Cüneyt , Bardakçı Osman , Uzunköy Ali , Guzelcicek Ahmet
Published: May 2020

Background:

Although LC-MS/MS is preferred as a reliable method, therapeutic enzyme
drugs in the blood matrix may lead to false results.

Objective:

The purpose of this article is to experimentally investigate the effect of five different enzymes
used in the treatment of metabolic diseases on blood immunosuppressant measurement.

Methods:

Five different enzyme drugs (galsulfase, alglucosidase alfa, imiglucerase, elosulfase alfa,
laronidase) were added to control materials containing tacrolimus, everolimus, sirolimus, and cyclosporine
A drugs. Measurements were performed using an LC-MS/MS instrument (Shimadzu
8040, Japan). The amount of deviations from the target values was calculated.

Results:

Blood Immunosuppressant levels significantly changed after the administration of enzyme
drugs. Four different enzyme drugs led to false-positive results in the tacrolimus levels at a rate of
10.58% (95% CI, 9.83-11.32) to 37.28% (95% CI, 33.55-41.27). The highest deviations were observed
with the administration of galsulfase and alglucosidase alpha in the sirolimus levels at rates
of 336.54% (95% CI, 306.25-366.82) and 395.88% (95% CI, 360.25-431.50), respectively.
Imiglucerase was the least effective enzyme for the sirolimus level (0.80% (95% CI, 0.71-0.89).
Different deviations between the ratios of - 9.37% (95% CI, -10.40 - -8.33) and 8.33% (95% CI,
7.41-9.24) were determined at the cyclosporin A level.

Conclusion:

Galsulfase, alglucosidase alpha, imigluserase, elosulfase alpha and laronidase can significantly
interfere with immunosuppressant measurements with LC-MS/MS. False immunosuppressant
results associated with enzyme injection may result in immunosuppression failure, organ
rejection. For the measurement of immunosuppressant levels, sampling should be done before the
enzyme infusion. Clinicians should question the time of enzyme infusion and sampling when confounding
results in immunosuppressant measurement.
Novel Technologies and Nanotoxicology of Medical Implants
Authors: Akçan Ramazan , Aydogan Halit C. , Yıldırım Mahmut Ş. , Taştekin Burak , Sağlam Necdet
Published: May 2020

Background/Aims:

Use of nanomaterials in healthcare applications increases in parallel to
technological developments. It is frequently utilized in diagnostic procedures, medications and therapeutic
implementations. Nanomaterials take place among key components of medical implants,
which might be responsible for certain toxic effects on human health at nano-level. In this review,
nanotoxicological effects, toxicity determination of nanobiomaterials used in human body and their
effects on human health are discussed.

Material and Method:

A detailed review of related literature was performed and evaluated as per
nanomaterials and medical implants.

Results:

The nanotoxic effects of the materials applied to human body and the determination of its
toxicity are important. Determination of toxicity for each nanomaterial requires a detailed and multifactorial
assessment considering the properties of these materials.

Conclusion:

There are limited studies in the literature regarding the toxic effects of nanomaterials
used in medical implants. Although these implants are potentially biocompatible and biodegradable,
it is highly important to discuss nanotoxicological characteristics of medical implants.
Магнитные и резонансные свойства поликристалла Y-=SUB=-0.5-=/SUB=-Sr-=SUB=-0.5-=/SUB=-Cr-=SUB=-0.5-=/SUB=-Mn-=SUB=-0.5-=/SUB=-O-=SUB=-3-=/SUB=-
Authors: Патрин Г.С. , Матаев М.М. , Сейтбекова К.Ж. , Шиян Я.Г. , Яриков С.А. , Жарков С.М.
Published: May 2020

Abstract The magnetostatic and magnetic resonance properties of the Y_0.5Sr_0.5Cr_0.5Mn_0.5O_3 polycrystalline system have been experimentally investigated. The predominance of the intracrystalline ferromagnetic interaction and the antiferromagnetic character of the intercrystallite interaction have been established. The magnetic resonance spectrum in the magnetically ordered region consists of two lines. The high-field line corresponds to the interacting parts of polycrystal shells and the low-field peak is related to the disordered system of ferromagnetic particles.
Исследования электрофизических свойств сегнетоэлектрических пленок Ba-=SUB=-0.8-=/SUB=-Sr-=SUB=-0.2-=/SUB=-TiO-=SUB=-3-=/SUB=- в параэлектрическом состоянии
Authors: Гольдман Е.И. , Нарышкина В.Г. , Чучева Г.В.
Published: May 2020

Abstract Phenomenological analytical expressions relating the ferroelectric film capacity to the coefficients of free energy decomposition in accordance to the degrees of substance polarization in paraelectric state are obtained. High-frequency capacitance-voltage characteristics of metal–Ba_0.8Sr_0.2TiO_3–metal structures have been measured at the temperatures above the transition point from ferroelectric phase to paraelectric one. The comparison of theoretical and experimental data has been resulted in plotting the dependences of Ba_0.8Sr_0.2TiO_3 film polarization on external voltage and determining the values of the parameters of the theory of phase transitions of second kind of Ginsburg–Landau for the objects under investigation.
Локализация моноклинной фазы в насцентных частицах сверхвысокомолекулярного полиэтилена
Authors: Анохин Д.В. , Графская К.Н. , Иванов Д.А. , Иванькова Е.М. , Марихин В.А. , Мясникова Л.П. , Иванчев С.С.
Published: May 2020

Annotation
The X-ray analysis of a virgin particle taken directly from the synthesis products of an ultra-high molecular weight polyethylene (UHMWPE) and not subjected to any external stresses was carried out using nanofocus beamline ID13 European Synchrotron Radiation Facility (ESRF, Grenoble,France). In the X-ray diffraction curves obtained by scanning an arbitrarily selected portion of a particle with a size of (100 x 20) μm2 by a microbeam (0.3 x 0.3) μm2 with a step of 2 μm horizontally and 0.5 μm vertically, along with reflections from the orthorhombic phase, reflexes from the metastable monoclinic phase were observed.
It is believed that the cause of its occurrence may be stresses that develop during specific structure formation in slurry synthesis and persist when cooled to room temperature and the solvent evaporates. The possibility of localization of the monoclinic phase in various morphological formations is discussed.
Association of Socioeconomic Status and Comorbidities with Racial Disparities during Kidney Transplant Evaluation
Authors: Murphy Karly A. , Jackson John W. , Purnell Tanjala S. , Shaffer Ashton A. , Haugen Christine E. , Chu Nadia M. , Crews Deidra C. , Norman Silas P. , Segev Dorry L. , McAdams-DeMarco Mara A.
Published: May 2020

Background and objectives

Black patients referred for kidney transplantation have surpassed many obstacles but likely face continued racial disparities before transplant. The mechanisms that underlie these disparities are unclear. We determined the contributions of socioeconomic status (SES) and comorbidities as mediators to disparities in listing and transplant.

Design, setting, participants, & measurements

We studied a cohort (n=1452 black; n=1561 white) of patients with kidney failure who were referred for and started the transplant process (2009–2018). We estimated the direct and indirect effects of SES (self-reported income, education, and employment) and medical comorbidities (self-reported and chart-abstracted) as mediators of racial disparities in listing using Cox proportional hazards analysis with inverse odds ratio weighting. Among the 983 black and 1085 white candidates actively listed, we estimated the direct and indirect effects of SES and comorbidities as mediators of racial disparities on receipt of transplant using Poisson regression with inverse odds ratio weighting.

Results

Within the first year, 876 (60%) black and 1028 (66%) white patients were waitlisted. The relative risk of listing for black compared with white patients was 0.76 (95% confidence interval [95% CI], 0.69 to 0.83); after adjustment for SES and comorbidity, the relative risk was 0.90 (95% CI, 0.83 to 0.97). The proportion of the racial disparity in listing was explained by SES by 36% (95% CI, 26% to 57%), comorbidity by 44% (95% CI, 35% to 61%), and SES with comorbidity by 58% (95% CI, 44% to 85%). There were 409 (42%) black and 496 (45%) white listed candidates transplanted, with a median duration of follow-up of 3.9 (interquartile range, 1.2–7.1) and 2.8 (interquartile range, 0.8–6.3) years, respectively. The incidence rate ratio for black versus white candidates was 0.87 (95% CI, 0.79 to 0.96); SES and comorbidity did not explain the racial disparity.

Conclusions

SES and comorbidity partially mediated racial disparities in listing but not for transplant.
Can Customer Intimacy Strategy Generate Intention to Buy?
Authors: Santosa MS. Eric
Published: May 2020

Creating customer intention to buy is obviously a major task of every marketer and/or firm. Many tactics are exercised to generate the intention, in which a buying behavior is hopefully occured. A customer intimacy strategy supposedly be a particular way to do it. However, its power to generate the intention hypothetically is not straight forward, but through other variables. It is commonly known, in accordance with the Theory of Planned Behavior (TPB), the intention could be predicted by consumer attitude and subjective norm. Meanwhile, the attitude and subjective norm theirself are frequently in-line with the product’s performance. Therefore.the purpose of the study is to investigate the power of customer intimacy strategy in creating the customer intention to buy through the product’s brand equity and both the consumer attitude and subjective norm. A 108 sample is withdrawn from those who recognize, are interested of and want to buy Dagadu products. Amos 16.0 and SPSS 16.0 are employed in analyzing data. The result shows that the customer intimacy strategy has significant effects to the brand equity, attitude and subjective norm. In addition, the brand equity also has a significant influence to the intention.
The Contribution of Collaborative Tasks to the Development of Mediation Competencies through Learning Management Systems
Authors: Efthimiadou Euphrosyne
Published: May 2020

In our digital era the adoption of innovative pedagogical approaches is based on the active involvement through collaborative tasks of the participants in the pedagogical process. In this context, mediation skills in the process of cultivating learning strategies play an essential role to the educational process and upgrade the contribution of the mentor-teacher, since the socio-emotional dimension of interpersonal relationships positively contributes to awareness and self-awareness. In addition, in an action-oriented approach, the creation of pedagogical scenarios through Learning Management Systems focuses on mediation skills through the exchange of experiences, skills and good practices, enabling each participant to exploit the group’s potential and to create strategic partnerships, which bring added value to the dynamic integration of the learners in social and professional frameworks.
CO-CRYSTALS OF ACTIVE PHARMACEUTICAL INGREDIENT-IBUPROFEN LYSINE
Authors: KULKARNI ALPANA , BACHHAV RITESH , HOL VISHAL , SHETE SWAPNIL
Published: May 2020

Objective: Co-crystal is defined as a crystalline complex of two or more neutral molecules bound together primarily by hydrogen bonding or other non-covalent interactions. The pharmaceutical co-crystal involves crystal lattice arrangement between an Active Pharmaceutical Ingredient (API) with another pharmaceutically acceptable molecule. Co-crystals of API are preferred since they depict improved solubility, dissolution, stability, compressibility in comparison with API. Ibuprofen lysine (IL), frequently used analgesic and the anti-inflammatory drug has poor aqueous solubility and compressibility. This work shows the feasibility and optimal conditions for the preparation of co-crystals of ibuprofen lysine using Polyvivylpyrrolidone K25 (PK 25) and Polyvivylpyrrolidone K30 (PK 30) as co-formers.

Methods: In this study, we prepared and studied the solubility, drug content, flow properties, physical stability of novel co-crystal, consisting of IL and PK 25/PK 30. The co-crystal IL: PK 30 (at a molar ratio of 0.29:0.5) and IL: PK 25 (at a molar ratio of 0.58:1) were characterized by X-ray analysis, infrared spectroscopy and thermal analysis. Furthermore, the tablet formulations of the co-crystals were subjected to in vitro dissolution and in vivo analgesic activity, with the goal of comparing the co-crystals with IL and the marketed tablet of ibuprofen (Brufen®) respectively.

Results: The IL: PK co-crystals demonstrated superior solubility and the dissolution properties over IL. The compression properties of the co-crystals were similar to IL. The co-crystals exhibited higher analgesic activity than the marketed tablet. 

Conclusion: The results indicated the use of PK 25 and PK 30 as safe and promising co-crystal formers.
DEVELOPMENT AND CHARACTERIZATION OF TOPICAL NANOPARTICULATE ANTIPSORIATIC POLYHERBAL CREAM
Authors: KHAN SHADAB , MULLA GHAZALA , BHISE KIRAN
Published: May 2020

Objective: The lack of possible cure and associated disadvantages of allopathic medicines in the topical treatment of psoriasis has led to extensive research for anti-psoriatic activities of plant-based drugs. The present study was aimed to develop topical cream formulation containing the Nanostructured Lipid Carriers of Azadirachta indica leaves extract (AE), Lawsonia inermis leaves extract (LE) and fruit extract of Mallotus philippensis (ME) and assessing the antipsoriatic activity of prepared cream formulation.

Methods: The Drug loaded NLCs were prepared via hot homogenization technique and incorporated into the water in oil (w/o) cream base that was prepared by the emulsification method. Evaluation of cream formulation included advanced preclinical trials using Rat Ultraviolet Ray-B photodermatitis and Mousetail method, anti-lipid peroxidation assay, nitric oxide scavenging activity, cytotoxicity and DNA fragmentation on HaCat cell lines to ascertain antipsoriatic potential and in vitro drug diffusion.

Results: In spite of the low amount of the drug loading in NLCs their potency was much higher as displayed in Advanced Preclinical studies and cell line studies for psoriasis indicating the suitability of NLCs loaded creams for skin applications due to their various desirable effects on the skin. Occlusive properties of the prepared NLC on the skin provide an increase in drug penetration particularly via skin moisturization. The in vitro drug diffusion studies suggest the prolonged and almost complete release of AE, LE and ME from NLC based cream up to 24 h that was found to be 81.24±0.51%, 74.31±0.25% and 70.43±0.78% respectively. The literature survey supports the novelty of such topical anti-psoriatic polyherbal nanoparticulate cream.

Conclusion: It can be concluded that the AE, LE and ME loaded NLC based cream can be used for prolonged topical delivery of drugs for the management of Psoriasis.
Calculation of deformations of a cantilever-frame planar truss model with an arbitrary number of panels
Authors: Buka-Vaivade Karina , Kirsanov Mikhail N. , Serdjuks Dmitrijs O.
Published: May 2020

Introduction. By method of induction using three independent parameters (numbers of panels) formulas for deflection under different types of loading are derived. Curves based on the derived formulas are analyzed, and the asymptotic of solutions for the number of panels are sought. The frame is statically definable, symmetrical, with descending braces. The problem of deflection under the action of a load evenly distributed over the nodes of the upper chord, a concentrated load in the middle of the span, and the problem of shifting the mobile support is considered.

Materials and methods. The calculation of forces in the truss bars is performed in symbolic form using the method of cutting nodes and operators of the Maple computer mathematics system. The deflection is determined by the Maxwell – Mohr formula. Operators of the Maple computer mathematics system are used for composing and solving homogeneous linear recurrent equations that satisfy sequences of coefficients of the required dependencies. The stiffness of all truss bars is assumed to be the same.

Results. All the obtained dependencies have a polynomial form for the number of panels. To illustrate the obtained solutions and their qualitative analysis, curves of the deflection dependence on the number of panels are constructed.

Conclusions. A scheme of a statically definable three-parameter truss is proposed that allows an analytical solution of the problem of deflection and displacement of the support. The obtained dependences can be used in engineering practice in problems of structural rigidity optimization and for evaluating the accuracy of numerical solutions.
Backwash water treatment by coagulation in the presence of phosphates at underground water iron removal stations
Authors: Zhytsianiou Barys N. , Yordanova Lyudmila E.
Published: May 2020

Introduction. The analysis of the present-day condition of water resources has proven the relevance and expediency of developing highly effective backwash water treatment methods to be used at iron removal stations designated for groundwater treatment. In accordance with effective technical regulations, backwash water must be reused. The operation of iron removal stations has proven the inefficiency of backwash water treatment facilities. Water and wastewater treatment companies stop using backwash water treatment facilities and refrain from reusing backwash water. Highly concentrated iron-bearing backwash water is discharged into sewage networks, nearby water bodies or onto the terrain, which means irrational use of high-quality groundwater and environmental pollution with iron compounds.

Materials and methods. The results of experimental research efforts and statistical processing of data on the qualitative and quantitative composition of backwash water at iron removal stations are presented. The chemical nature of the components and the principle underlying the formation of the backwash water composition in the process of groundwater deferrization have been studied. It’s been identified that if backwash water supplied by iron removal stations is treated by sodium phosphate reagent Na3PO4 and aluminum sulphate Al2(SO4)3 as a coagulant, precipitation of iron compounds intensifies, as colloidal particles FePO4 are formed. They have very low solubility, and they are effectively removed by coagulation. It has been theoretically proven and experimentally confirmed that anions H2 PO4– and PO4 3– fformed in the process of hydrolysis of sodium phosphate Na3PO4 help to reduce the electrokinetic charge of the colloidal particle of iron hydroxide Fe(OH)3, and high purification efficiency reaching 99.0–99.9 % is attained by attaching iron compounds to the surface of the colloidal particle of aluminum hydroxide Al(OH)3.

Conclusions. The co-authors have developed a math-and-stats model simulating the backwash water treatment process that employs coagulation in the presence of phosphates. It describes the dependence between the concentration of residual iron, doses of sodium phosphate Na3PO4, aluminum sulphate Al2(SO4)3 and the settling time. A backwash water treatment technology has been developed. It employs coagulation in the presence of phosphates, and it is designated for use at iron removal stations. This technology comprises a chemical plant for sodium phosphate and aluminum sulphate used as a coagulant, a post-treatment filter, and sludge dewatering facilities. The application of this technology enables to reduce iron concentration to 0.05–0.20 mg/l, to reuse backwash water for drinking and other household purposes, or to have this water reused by iron removal stations, this, preventing pollution of water sources with iron compounds.
Numerical analysis, design and behavior of rockfill dams with reinforced concrete faces during seismic actions
Authors: Lyapichev Yury P.
Published: May 2020

Introduction. Over the last 10–20 years many rockfill dams with reinforced concrete faces that are 140–200 m high (Mohale in Lesotho, Tian Sheng Yao, Zipingpu in China, etc.) have experienced serious problems, including face slab cracking and perimeter joint opening. Most of these dams were built in high seismic hazard areas, and their seismic resistance to the maximal earthquake exposure, having the magnitude equal to 8–9, raises doubts. The goal of this research is to employ numerical methods to verify the seismic resistance of dams, to project their behavior in case of the seismic exposure that may damage the dam face, cause the face joints to open and the dam face to detach from its toe, etc. Materials and methods. The author offers his analysis of reliability and applicability of numerical methods to the seismic resistance of dams. Incidents have demonstrated the need for a thorough assessment and analysis of each aspect of a new project whenever it is extrapolated from the precedent. Results. The analysis of the dam behavior in the course of the first reservoir filling has demonstrated face top cracking that causes its damage. Deeper in the water, face joints may be exposed to localized damages due to compression and shear; one should expect vertical face joints to open; excessive compressibility of the downstream rockfill zone may cause the water to leak through the dam face. The author offers recommendations for the performance of the dynamic analysis of dams in respect of the boundaries of the computational domain, given that seismic waves are transmitted or absorbed at the interface between the dam face and the transition zone, on the one hand, and between dam slabs, on the other hand. In furtherance of his recommendations, real and synthetic accelerograms are applied to the bottom boundary of the computational domain; the choice of an explicit or implicit computational method should be made; the author’s method pre-sets the intermediate solution which is to comply with the accelerogram digitization pattern. Conclusions. In addition to internationally established measures for improving the static and seismic safety of dams, the author proposes a new effective dam safety improvement method to be used in the course of designing high dams to be con-structed in high seismic hazard areas. This method improves dam safety by drastically reducing face deflections with the help of a support zone made of roller compacted concrete instead of the gravel transition zone, as exemplified by the 275 m high Kambaratinskaya-1 dam in Kyrgyzstan and the 192 m high Sogamoso dam in Colombia (both dams are located in highly seismic regions). The information on China's successful track record in designing and building similar dams, which are 220–250 m high, is also provided.
Porosity and joint property of laser-MIG hybrid welding joints for 304 stainless steel
Authors: Cai Detao , Luo Ziyi , Han Limei , Han Shanguo , Yi Yaoyong
Published: May 2020

Laser-metal inert gas (MIG) hybrid butt welding was carried out on 5 mm-thick 304 stainless steel to study the influence of parameters on porosity defect, weld formation, and property of the joints. Research reveals that laser-MIG hybrid welding of 304 stainless steel has porosity sensitivity. The effects of welding speed and laser power on porosity and formation of welds were analyzed. Results show that increasing of laser power and decreasing of welding speed are conducive to improve the formation of welds and reduce porosity. Improving the welding speed on the premise of ensuring proper weld formation is of considerable significance, which is recommended to be 1.8 m/min. Based on the fixed welding speed, parameter of laser power optimization is carried out. Results show that tensile strength and elongation of the welded joints reach at least 98.1% and 75.8% of the base metal when laser powers are 4.3 and 5.0 kW. Compared with real-time monitoring and the numerical simulation method, this kind of results-oriented optimization parameter method has engineering guiding significance.
Application of Social Capital-Based Strategies in Creating Competitive Advantage in the LPD Penglatan Village, Singaraja
Authors: Kusuma Gusti Putu Eka
Published: May 2020

The purpose of this study was to find out how the application of social capital-based strategies to the Penglatan LPD. The analytical method used is qualitative descriptive approach, where social capital-based strategies in which focus on the external environment which includes relating to social networks, norms and beliefs are built to determine decision making in creating competitive advantage. In this study The selected informants included Head of Penglatan LPD, Employee of Penglatan LPD and Adat Bendesa of Penglatan Village
Online Interactive Multimedia Oriented to HOTS through E-Learning on Physics Material about Electrical Circuit
Authors: Widyaningsih Sri Wahyu , Yusuf Irfan , Prasetyo Zuhdan Kun , Istiyono Edi
Published: May 2020

This article explains the development of interactive multimedia which is designed using e-learning. The development technique uses ADDIE model which consists of some stages namely Analyze, Design, Development, Implementation, and Evaluation. The trial subjects in this study were 13 students of Physics Education Department in Universitas Papua who programed basic physics courses in the even semester of 2018-2019. Interactive multimedia validity was obtained based on an assessment sheet filled by 7 validators consisting of material expert validators, media experts and practitioners. Meanwhile, the effectivity and practicality of interactive multimedia was obtained based on the students’ responses after learning. The instrument used in this study was the validation sheet filled out by the validators and questionnaire about students’ responses after learning. The technique used to analyze the results of the validator's assessment was V Aiken while the questionnaire analysis used Rasch model. The results showed that the developed learning media were in the valid category for each aspect of the assessment, namely layout, navigation, functions, and pedagogy aspects. Moreover, students’ responses towards interactive multimedia used were also effective and practical in every aspect of assessment. Students gave good responses towards HOTS abilities that could be developed during learning, including the ability to analyze, evaluate, and create. Therefore, online interactive multimedia oriented to HOTS through e-learning can be applied in physics lesson.
Classification of Student Reasoning Skills in Solving Mathematics Problems in Elementary School
Authors: Sulianto Joko , Sunardi Sunardi , Anitah Sri , Gunarhadi Gunarhadi
Published: May 2020

The purpose of this study was to describe the classification of students' reasoning abilities in solving mathematical problems in elementary schools. The focus of this study is the classification of students' reasoning abilities in solving mathematical problems in the elementary schools of the city of Semarang. This study uses a qualitative approach. The Research subject is elementary school students at Tambakrejo Elementary School Semarang. Data is taken using tests. Based on data analysis, the reasoning classification is as follows: 36.25% understand the meaning in low categories, 37.5% think logically in low categories, 31.1% understand negative examples in low categories, 17.05% think deductions in very low category, 18.15% think systematically in very low categories, 31.65% think consistently in low category, 34.85% make excuses and determine strategies in low category, 49.85% determine method in low category, and 24.3% draw conclusions in low category. Thus the reasoning ability of students is low, students have not been able to think logically to make connections between empirical facts and the problems faced so they are not able to draw conclusions, students have not been able to do the thinking process to make arguments so that new statements are based on facts, it is necessary to develop learning models to improve mathematical reasoning of elementary school students
LAICIDADE E EDUCAÇÃO: O PE. LEONEL FRANCA S.J. E O DEBATE SOBRE O DECRETO DO ENSINO RELIGIOSO NA ESCOLA PÚBLICA BRASILEIRA (1931)
Authors: Fabrício Edison Lucas
Published: May 2020

O artigo busca contextualizar as aspirações da Igreja Católica no campo educacional da Primeira República e mostrar como a hierarquia católica se articulou para que o ensino religioso retornasse à legislação, em 1931. No campo educacional e político, destaca-se a ação do Pe. Leonel Franca S.J. e seus esforços em prol do ensino religioso, especialmente através do livro Ensino religioso, ensino leigo. Por outro lado, evidencia-se a oposição ao decreto do ensino religioso por líderes protestantes, anarquistas e intelectuais, como o historiador Sergio Buarque de Hollanda.
O conceito de dignidade humana e direitos humanos
Authors: Anacleto Gesiel
Published: May 2020

O presente artigo pretende trazer uma discussão sobre o conceito de dignidade humana e direitos humanos. Nosso objetivo será refletir sobre o conceito de dignidade humana e suas implicações na elaboração dos direitos humanos e nas discussões atuais acerca desta temática. No sentido de delimitarmos nossa análise recorremos a dois autores: Habbermas e Forst. Inicialmente faremos alguns esclarecimentos das diferenças entre a Moral e o Direito, para em seguida introduzirmos a questão da dignidade e dos direitos humanos, bem como a esfera pública como um espaço de justificação. Defenderemos o conceito de dignidade humana como fundamento da crítica em relação aos problemas relativos aos direitos humanos que a sociedade enfrenta. Ao final apresentaremos algumas considerações pertinentes a discussão e de que maneira este debate poderá contribuir para a ampliação dos direitos humanos e a garantia de uma sociedade mais justa.
Palavras-chaves: Dignidade Humana. Direitos Humanos. Moral.