bluuebunny/crossref_metadata_2025 huggingface dataset:
Overview Role of Simulation Package in Virtual Manufacturing and for CNC Machinery
Authors: Mahesh R. , Murali J. Ganesh , Arulmurugan R.
Published: May 2018

Computer Numerical Control Machines (CNC) totally changed the scenario in manufacturing industries in terms of production volume, easy flexibility and with fewer deviations.    As customers expect high grade of accuracy, precision, reliable and prompt supply it became essential in the manufacturing sector to reduce the time for developing and proving out new products. Normally programming and proving out the same plays a significant role in the product development cycle. Nowadays several software packages are there to stimulate the tool path, sequence of operations and validation of the program to ensure flawless performance. These packages do serve additional role of optimizing the program sequence and reduce the cycle time involved to manufacture the parts concerned.
Scalable density based spatial clustering with integrated one-class SVM for noise reduction
Authors: Ahmed K. Nafees , Razak T. Abdul
Published: May 2018

Information extraction from data is one of the key necessities for data analysis. Unsupervised nature of data leads to complex computational methods for analysis. This paper presents a density based spatial clustering technique integrated with one-class SVM, a machine learning technique for noise reduction, a modified variant of DBSCAN called NRDBSCAN. Analysis of DBSCAN exhibits its major requirement of accurate thresholds, absence of which yields suboptimal results. However, identifying accurate threshold settings is unattainable. Noise is one of the major side-effects of the threshold gap. The proposed work reduces noise by integrating a machine learning classifier into the operation structure of DBSCAN. Further, the proposed technique is parallelized using Spark architecture, thereby increasing its scalability and its ability to handle large amounts of data. Experiments and comparisons with similar techniques indicate high scalability levels and high homogeneity levels in the clustering process.
Improving air quality management using gradient boosting based hierarchical temporal memory neural networks and fuzzy based classification based regression tree
Authors: S Sagayaraj , N Vetrivelan
Published: May 2018

In recent years, air pollution introduces different biological molecules, particulate and several harmful materials which affect the human health and activities. So, the quality of the air should be maintained for avoiding the above issues. To manage the air quality initially the meteorological data have been collected from Ariyalur that includes the condition of air, data collected date, high and low temperature, wind speed, wind direction and relative humidity. The collected data has to be preprocessed by applying the normalization and data mining techniques and those preprocessed data’s are used to predict the pollutants and the concentration level of the pollutants such as sulfur dioxide (SO2), carbon monoxide (CO), nitrogen dioxide (NO2), and nitric oxide (NO). Then the particulate matter level in the air has to be predicted by Gradient Boosting based Hierarchical Temporal Memory Neural Networks (BHTMNN). From the predicted value the strength of the pollutants is classified by using the Fuzzy based Classification based Regression Tree (FCART) which is used to recognize the disease arises in the human respiratory system. Then the performance of the proposed system is evaluated using the mean square error, classification accuracy, sensitivity and specificity.
Key agreement based secure Kerberos authentication protocol (KASKAP) for distributed database access in secured manner
Authors: M Natarajan , R Manimegalai
Published: May 2018

Distributed database is a collection of multiple databases that can be stored at different network sites. It acts as an important role in today’s world intended for storing and retrieving huge data. The implementation of distributed database advantages such as data replication, low operating costs, faster data transaction and data processing, but security is still a significant problem. In this paper make clear to explain security issues of distributed database and give the suggestion to improve security of distributed database. Subsequently, secured distributed database design in light of trusted node is proposed. The design contains a unique node in a system called a trusted node for each site through which every single other node will get to the database. Trusted node process client demands, joins the outcomes from concerned distributed databases and forward it to the confirmed client. The system adjusted by the trusted nodes keeping in mind the end goal to give authentication is Key Agreement based Secure Kerberos Authentication Protocol (KASKAP). Hence authenticated users can only access the database.
Three phase voltage source inverters with grid connected industrial application
Authors: N Prakash , V.R. Balaji
Published: May 2018

The grid-connected issue is one of the major problems in the field of Power Electronics. In this paper, the Three Phase Voltage Source Inverter (VSI) is controlled by a Space Vector Pulse Width Modulation (SVPWM) Technique. SVPWM control technique and Park transformation, the managed inverter control system to convert input DC power into AC power, stabilize the output voltage and current, and feeds the excess power to the utility grid can be achieved by controllers. Usually, the grid source contains higher level of harmonics. To analyze the harmonics, nonlinear load is connected externally in the point of common coupling. The main aim of this paper is to modeling, simulation and experimental study of the three-phase grid connected inverter. By using the control algorithm, the grid sides Total Harmonics Distortion (THD) are controlled to the 1.54% for 800V DC as per the IEEE standard. The stimulation results such as AC output voltage and current, inverter system power flow, and grid disturbances detection signals, proves the effectiveness of the developed control algorithm. The control algorithms to makes the for this inverter outputs is pure sinusoidal.
Development of mobile adhoc network using leader Selection algorithm
Authors: Deepa S. , S Kamal Raj , K.P Sridhar
Published: May 2018

Mobile ad-hoc network (MANET) is an interconnection of mobile devices without preexisting topology which form a communication network. QOS parameters like congestion control, confidentiality, output, delay, energy consumption, jitter, have to be improved based on the development of transmission technology, and real-time applications. MANETs are totally different from distributed COMPUTING systems. They are dynamic and self-organizing networks. A leader is needed to coordinate and organize tasks in MANET. The challenge is to own the proper election algorithm that chooses the correct leader based on numerous factors in MANET. The task of the leader is to keep up the quality of service (QOS) in the MANET. This paper explores QoS in MANET by using the leader of the network by correct election algorithm by improving the network lifetime, path stability, and reduce end to end delay.
El impacto de una reforma: Limitación de la autonomía, estrechamiento de la libertad y erosión de la participación
Authors: Prieto Miriam , Villamor Patricia
Published: May 2018

Los sistemas educativos de todo el mundo están implantando medidas dirigidas a la mejora de la calidad de la educación. Estas medidas conllevan la configuración de una retórica que sirve de marco para la interpretación de la acción de los agentes educativos. El artículo aborda el estudio de la configuración del significado de los conceptos de autonomía, libertad y participación de los agentes educativos −profesorado y familias− en el sistema educativo madrileño. Para ello, se toma como contexto el significado que se atribuye a estas nociones en el sistema educativo español, mediante el análisis de su evolución en los textos de las legislaciones que lo regulan. A continuación, se presenta la reforma implantada en el sistema educativo madrileño, mediante la confrontación de los discursos de los principales agentes políticos y de la legislación educativa que han desarrollado. El impacto de la reforma implantada en el sistema educativo madrileño se conceptualiza en términos de limitación de la autonomía del profesorado, y erosión de la participación y estrechamiento de la libertad de las familias.
A Study of Compost as an Adsorbent for Congo Red Dye Removal Process
Authors: Kristanto Gabriel Andari , Raindra Lamurvie Ariessyawtra , Koven William
Published: May 2018

The human population continues to grow annually, and so does the number of textile industries. In textile industry, synthetic dye is one of the most polluting substance in its wastewate which the conventional treatment processes are usually ineffective. Another option is using activated carbon to remove the dye, but carbon is an expensive material. It is is interesting that  material that is rich in carbon, such as compost, may become an alternative solution. The objective of the present study was to assess the capability of compost in treating wastewater dye by determining the optimum compost dosage, particle size, and column height, while considering dye percentage removal and adsoprtion capacity. The optimum compost dosage was 8g/L and the optimum particle size was 1–2 mm in treating the 200 ppm Congo Red dye molecule, resulting in 20.49% removal and a 5.33 mg/g adsorption capacity. The optimum compost column height was 60 cm with 90% removal, and the adsorption capacity was 0.38 mg/g. The dye molecule wore off tthe compost, therefore fresh compost must be introduced in order to maintain its percentage removal level. The compatibility of isotherm model developed in this study with the Freundlich model is similar with previous studies.    Keywords: compost; congo red dye;adsorbent, batch, column
Short Sale Constraints, Correlation and Market Efficiency
Authors: Giannikos Christos , Gousgounis Eleni
Published: May 2018

This paper models a market where short sales are prohibited and investors have heterogeneous beliefs on asset values. We show that short sale constraints may cause overpricing, the magnitude of which depends on not only investors’ opinion dispersion on the value of the particular asset, but also on its correlation to other assets, as well as, the investors’ opinion dispersion for the values of those other assets.
A Zariski--Nagata theorem for smooth ℤ-algebras
Authors: De Stefani Alessandro , Grifo Eloísa , Jeffries Jack
Published: May 2018

In a polynomial ring over a perfect field, the symbolic powers of a prime ideal can be described via differential operators: a classical result by Zariski and Nagata says that the n-th symbolic power of a given prime ideal consists of the elements that vanish up to order n on the corresponding variety. However, this description fails in mixed characteristic. In this paper, we use p-derivations, a notion due to Buium and Joyal, to define a new kind of differential powers in mixed characteristic, and prove that this new object does coincide with the symbolic powers of prime ideals. This seems to be the first application of p-derivations to commutative algebra.
Controlling for Import Price Effects in Civil War Regressions
Authors: Janus Thorsten , Riera-Crichton Daniel
Published: May 2018

Several studies estimate the effects of commodity export prices on economic outcomes, such as conflict and democratic transitions. In this note, we argue that it is important to control for the effects of import prices due to two reasons. First, economic theory predicts that both import and export prices affect the economy’s performance, which can, in turn, affect its conflict propensity. Second, the facts that import prices might affect the conflict risk and that import and export prices can be correlated imply that the failure to control for import price effects can bias the export price coefficients. We illustrate these points using the dataset and one of the regression specifications in a recent civil war study.
IMPROVEMENTS ON THE ELECTRIC DRIVE ELEVATOR PROTOTYPE. PART I TECHNICAL ASPECTS
Authors: Gaiceanu M. , Epure S.
Published: May 2018

The objective of the paper is to present some improvements done on the previously described electric drive elevator prototype [1]. The modern electric elevator contains both the cabin (replaced at the research laboratory by one trolley), and the counterweight (replaced by the opposite trolley which contains modular weights). Through the appropriate gearbox the connexion between the pulley and electric motors is provided. The designed load of the elevator conducts to the 4kW three-phase squirrel cage driven motor supplied by the power inverter prototype through the chain transmission. The modified experimental platform is depicted and the adequate experimental results are provided.
HIGHER EDUCATION IN BULGARIAN CONTEXT: PECULIARITIES AND CHALLENGES
Authors: Milenkova Valentina , Hristova Svetlana D.
Published: May 2018

The objective of this article is to illustrate the issues and challenges which the higher education system in Bulgaria faces, with a particular accent on the phenomenon “education per kilogram”. The latter describes, in a popular language, the up-scaling of the university graduation, related to the mass proliferation of the higher education institutions (HEIs), the facilitated access to enrolment through paid tuitions, etc. The big quantity of HEIs in the country is in a mismatch with the low percentage of GDP which the government dedicates to education. The number of HEIs is also disproportionate against its population size - 54 HEIs in Bulgaria for population of 7.2 million. The research methodology includes a desktop study based on national statistical data and data from the governmentally-supported university rating system. An empirical survey, conducted among 250 tertiary education students enrolled in four Bulgarian universities, is a valuable contribution towards disclosing the pros and cons of the teaching practices in the tertiary education in the country. The first chapter describes at large the “education per kilogram” issue with regard to its possible origins, variations and consequences for the misbalance of labour market demand for certain qualifications and the universities supplies of qualified individuals. The second chapter reveals a comparative analysis by professional fields possible through the Ministry of Education and Science’s university rating system, i.e. students’ preferences for disciplines, universities and professions; the graduates’ professional fulfilment and how the income of the recent diploma-holders is a function of attending a particular HEI. The third chapter presents a sociological survey conducted among students in four Bulgarian universities which demonstrates learners’ attitudes towards various aspects of training, teaching methods and involvement in research assignments in the context of tertiary education.

The main conclusion of the article is that the “universities per kilogram” trend brought about other corresponding characteristics, such as “students per kilogram”, “academic titles per kilogram”, etc. Hence, the large number of HEIs in Bulgaria has not led to improving the quality and efficiency of education, and yet does not respond adequately to the changing labour market demands for qualified professionals.
THE POST-MODERN AS NEO-MEDIEVAL: INTERSECTIONS OF RELIGION, NATIONALISM, AND EMPIRE IN MODERNITY AND BEYOND (WITH AN EXCURSUS ON ALBANIAN NATIONALISM)
Authors: Demjaha Dritëro
Published: May 2018

This essay connects Benedict Anderson’s analysis of print capitalism as the enabling feature of modernity for the emergence of nationalism with an account of pre-modern sacral imaginings. It argues, following Bronislaw Szerszynski, that the contemporary post-modern ordering of the sacred vis-à-vis nature and culture designates a ‘partial-return’ to pre-modern imaginings and a reterritorialisation of religions which engenders emerging multiplicities and co-existing differences. It argues furthermore that the nation state (and its corollaries), an institution of modernity cannot adequately respond to the antagonisms generated by the post-modern ordering of human communities and their identities. However, though this new ordering may be conceived, following Robert Bellah, as neo-archaic, it may also be conceived as neo-medieval. Accordingly, this essay proposes that the most congenial configuration to the post-modern ordering is the neo-medieval model of fuzzy borders and overlapping jurisdiction, particularly as it pertains to Albanian national identity and EU integration as a post-secular alternative to secular national-determination on the one hand, and neo-Ottomanist theocracy on the other.
Effort Index as a Novel Variable for Monitoring the Level of Effort During Resistance Exercises
Authors: Rodríguez-Rosell David , Yáñez-García Juan M. , Torres-Torrelo Julio , Mora-Custodio Ricardo , Marques Mário C. , González-Badillo Juan J.
Published: May 2018

Rodríguez-Rosell, D, Yáñez-García, JM, Torres-Torrelo, J, Mora-Custodio, R, Marques, MC, and González-Badillo, JJ. Effort index as a novel variable for monitoring the level of effort during resistance exercises. J Strength Cond Res 32(8): 2139–2153, 2018—This study aimed to analyze the acute mechanical and metabolic response to resistance exercise protocols (REPs) defined by 2 variables: the first repetition's mean velocity and the percentage of velocity loss (%VL) over the set. The product of these 2 variables was termed the effort index (EI) and was used as an indicator of the degree of fatigue induced during each REP. Twenty-one resistance-trained men (11 in full squat [SQ] and 10 in bench press [BP]) performed 16 REPs separated by 72 hours. Relative loads used (50, 60, 70, and 80% 1-repetition maximum) were determined from the load-velocity relationship for the SQ and BP, whereas volume was objectively determined using the %VL attained over the set (10, 20, 30, and 45% for SQ, and 15, 25, 40, and 55% for BP). Lactate concentration and velocity against the load that elicited a ∼1.00 m·s−1 (V1 m·s−1 load) were measured before and after each REP. Post-exercise velocity with the V1 m·s−1 load and lactate concentration were significantly different (P < 0.01–0.001) from pre-exercise after all REPs. A very close relationship was found between the proposed EI and %VL with the V1 m·s−1 load (r = 0.92–0.98) and post-exercise lactate concentration (r = 0.91–0.95) in both exercises. The correlations between this new index and fatigue indicators such as VL allow us to gain further insight into the actual degree of effort incurred during resistance exercise. In addition to being a valuable addition for training monitoring, the proposed EI could also be used as an independent variable in training studies by equalizing the effort between different interventions.
Gender Differences in Patients with Anxiety after Coronary Artery Bypass Surgery
Authors: Guzelhan Yalcin , Conkbayir Cenk , Ugurlucan Murat , Yildiz Cenk Eray , Alpagut Ufuk , Bozbuga Nilgun
Published: May 2018

Objective: The present study was designed to evaluate the relationship between gender and coexisting anxiety in patients undergoing coronary artery surgery. Materials and Methods: A total of 137 patients (41 women and 96 men with a mean age 66.1 ± 6.0 years) patients underwent state and trait anxiety evaluation at baseline (preoperatively) and at six months after (postoperatively) coronary artery bypass graft (CABG). Anxiety symptoms were assessed at enrollment using the Spielberger State-Trait Anxiety Inventory (STAI). Psychological, social, clinical, and surgical data were assessed statistically. Results: There were statistically significant differences between female and male patient characteristics for the mean age, mean education year, and mean body mass index. The women were found to be statistically younger and less educated, and more likely to be overweight, diabetic, and hyperlipidemic. The mean hospitalization time, wound infection, and extreme postoperative pain complaints were found to be higher in the female group. 61 patients (33 female and 28 male) (44.5%) were classified as presenting clinically significant anxiety symptoms (STAI score of ≥ 40). The female patients’ STAI scores were significantly higher than men in state and trait anxiety, both preoperatively and six months postoperatively. Postoperatively, there was not any significant decrease in the level of trait anxiety when comparing the level of state anxiety in female patients.  Conclusion: Even after adjusting for known risk factors for compromised STAI, women do not show the same long-term quality benefits of CABG surgery that men do. The results indicate that the STAI is a valuable instrument for identifying and supporting patients with higher levels of anxiety, which can aid in determining patients that may have poor adjustment after CABG surgery.
Histidine-Tryptophan-Ketoglutarate Solution versus Blood Cardioplegia in Cardiac Surgery: A Propensity-Score Matched Analysis
Authors: Pizano Alejandro , Montes Felix Ramon , Carreño Marisol , Echeverri Dario , Umaña Juan Pablo
Published: May 2018

Background: Choosing a cardioplegic solution is a significant issue in modern cardiac surgery. Although different options are available, the optimal strategy for myocardial protection has not been established. The aim of this study was to compare intraoperative and postoperative effects of histidine–tryptophan–ketoglutarate (HTK) solution with those of standard blood cardioplegia with St Thomas No 2 solution. The study was conducted using a large cohort of adult patients undergoing complex cardiac surgery.Methods: This study was a single center retrospective review of prospectively collected data. Between January 2008 and December 2015, 4480 patients underwent cardiac surgery using cardiopulmonary bypass (CPB) and cardioplegic arrest. Patients were divided into a blood cardioplegia group (n = 3852) and an HTK solution group (n = 628). Propensity score matching was used to adjust for differences between the two groups, and 292 matched pairs were identified. The primary end point was Intensive Care Unit (ICU) length of stay (LOS). Secondary end points included intraoperative changes in serum sodium concentration, readmission to ICU, transfusion of blood products, 30-day hospital readmission, 30-day mortality, and the incidence of major postoperative complications. Results: No significant differences were found between the matched groups with regard to baseline characteristics. Aortic cross-clamp and CPB times were longer for the blood cardioplegia (147.4 versus 132.8 min; P < .001). Administration of HTK solution was associated with acute and transient hyponatremia (141 versus 130 mmol/L; P < .001). ICU LOS was comparable between the groups (5.4 versus 5.4 days; P = .585). No significant differences were noted in any other secondary end point.Conclusions: During complex cardiac surgery, both cardioplegia techniques were equivalent in terms of early clinical outcomes.
Off-Pump Coronary Artery Bypass Grafting Improves Early Clinical Outcomes Including Operative Mortality
Authors: Vettath, Murali P. , Ravisankar Madhu , Kopjar Tomislov , Kannan AV , Gangadharan Nitin
Published: May 2018

Background: Whether coronary artery bypass grafting (CABG) should be performed on- or off-pump remains a matter of debate. We aim to present our experience with off-pump CABG. Early clinical outcome and adverse events were analyzed over the time course of the study. Methods: A total of 4310 patients undergoing isolated off- pump CABG from January 2002 until December 2016 at the Malabar Institute of Medical Sciences in India were included. Preoperative, intraoperative, and postoperative, as well as follow-up data were prospectively collected. To analyze the differences of patient characteristics and outcomes over time, five-year periods were created (early: 2002-2006; middle: 2007-2011; late: 2012-2016). Traditional techniques of quality control monitoring were applied. Results: The mean age of our patients was 59 ± 9 years, and 13% (533) were female. Postoperative mortality was observed in 0.7% (25), acute renal failure and stroke in 0.2% (8) each, and mediastinitis in 1.2% (53) of the patients. Despite the progressive worsening of the patient risk profile, significant improvement in mortality was observed over time, while stroke, acute renal failure, and mediastinitis remained similar. Continuous quality control monitoring revealed that the system was within the control boundaries for the entire period of the study. The current probability of 30-day mortality or conversion to on-pump CABG is about 0.5%. Conclusion: Off-pump CABG is safe and effective for patients undergoing CABG. It can provide superior results compared to on-pump CABG, particularly when performed by a dedicated off-pump surgeon.
Midterm Results of Routine Bilateral Internal Thoracic Artery Grafting
Authors: Kramer A. , Mohr R. , Lev-Ran O. , Braunstein R. , Pevni D. , Locker C. , Uretzky G. , Shapira I.
Published: May 2018

Background: Skeletonized dissection of the internal thoracic artery (ITA) decreases the occurrence of sternal devascularization, thus decreasing the risk of postoperative sternal complications in patients undergoing bilateral ITA grafting. Methods: From April 1996 to July 1999, 1000 consecutive patients underwent bilateral skeletonized ITA grafting. Of the 770 male and 230 female patients, 420 were older than 70 years, and 312 had diabetes. Results: Operative mortality was 3.3%. Follow-up (4078 months) revealed 79 late deaths, and the Kaplan-Meier 6-year survival rate was 88%. Cox regression analysis revealed increased overall mortality (early and late) in patients with preoperative congestive heart failure (risk ratio [RR], 2.13; 95% confidence interval [CI], 1.31-3.45), in patients with peripheral vascular disease (RR, 5.52; 95% CI, 3.31-9.19), and in patients older than 70 years (RR, 2.18; 95% CI, 1.37-3.47). Early postoperative morbidity included sternal infection (2.2%), cerebrovascular accident (1.6%), and perioperative myocardial infarction (1%). Multiple regression analysis showed repeat operation (odds ratio [OR], 7.5; 95% CI, 1.77-31.6) and chronic obstructive pulmonary disease (OR, 3.6; 95% CI, 1.27-10.75) to be independent predictors of sternal infection. During follow-up, angina returned in 95 patients, 24 of whom required reintervention (20 cases of percutaneous balloon angioplasty and 4 reoperations). Postoperative coronary angiography performed in 87 patients revealed an ITA patency rate of 91%. Conclusions: Bilateral skeletonized ITA grafting is associated with satisfactory early and midterm results. We do not recommend the use of this surgical technique in patients with chronic obstructive pulmonary disease.
Assessment of an Organ-Specific de Novo Transcriptome of the Nematode Trap-Crop, Solanum sisymbriifolium
Authors: Wixom Alexander Q , Casavant N Carol , Kuhl Joseph C , Xiao Fangming , Dandurand Louise-Marie , Caplan Allan B
Published: May 2018

Solanum sisymbriifolium, also known as “Litchi Tomato” or “Sticky Nightshade,” is an undomesticated and poorly researched plant related to potato and tomato. Unlike the latter species, S. sisymbriifolium induces eggs of the cyst nematode, Globodera pallida, to hatch and migrate into its roots, but then arrests further nematode maturation. In order to provide researchers with a partial blueprint of its genetic make-up so that the mechanism of this response might be identified, we used single molecule real time (SMRT) sequencing to compile a high quality de novo transcriptome of 41,189 unigenes drawn from individually sequenced bud, root, stem, and leaf RNA populations. Functional annotation and BUSCO analysis showed that this transcriptome was surprisingly complete, even though it represented genes expressed at a single time point. By sequencing the 4 organ libraries separately, we found we could get a reliable snapshot of transcript distributions in each organ. A divergent site analysis of the merged transcriptome indicated that this species might have undergone a recent genome duplication and re-diploidization. Further analysis indicated that the plant then retained a disproportionate number of genes associated with photosynthesis and amino acid metabolism in comparison to genes with characteristics of R-proteins or involved in secondary metabolism. The former processes may have given S. sisymbriifolium a bigger competitive advantage than the latter did.
Business performance management in university hospitals: a diagnosis in Brazilian institutions
Authors: Portulhak Henrique , Martins Daiana Bragueto , Espejo Márcia Maria Dos Santos Bortolocci
Published: May 2018

Objetivo Investigar si la evaluación del desempeño empresarial es una práctica utilizada por los hospitales federales brasileños, y en caso que haya instituciones que utilicen esta herramienta, verificar cuales prácticas son utilizadas e investigar las posibles características que permiten adoptar las mismas.Método El estudio utilizó la investigación descriptiva, siendo ex post facto en cuanto a los efectos en las variables estudiadas, y con relación a los procedimientos técnicos, se utilizaron datos secundarios y recursos de encuesta.Resultados Los resultados muestran que cuatro hospitales utilizan prácticas sobre la evaluación del desempeño empresarial; tres de ellos declararon que utilizan dos tipos de prácticas diferentes y que el 75 % de los hospitales universitarios que tienen al menos una práctica de evaluación del desempeño empresarial, también tienen un plan estratégico con visión, misión e objetivos y planes operativos a largo plazo. Entre los hospitales que no tienen prácticas sobre la evaluación del desempeño empresarial, el 55,6 % afirman tener una planificación estratégica compuesta al menos de misión, visión y objetivos a largo plazo. Sin embargo, declararon que la entidad no tiene planes de adoptar ningún método elencado.
Új és hagyományos irányok a gyermekkori akut lymphoblastos leukaemia biológiájában és ellátásában
Authors: Egyed Bálint , Kovács Gábor , Kutszegi Nóra , Rzepiel Andrea , Csányiné Sági Judit , Erdélyi Dániel János , Müller Judit , Félné Semsei Ágnes
Published: May 2018

Abstract:

Owing to clinical trials and improvement over the past few decades, the majority of children with acute lymphoblastic leukemia (ALL) survive by first-line chemotherapy and combat with the problems of returning to community. However, many patients may have severe acute or late therapeutic side effects, and the survival rate in some groups (e.g., patients with MLL rearrangements, hypodiploidy, IKZF1 mutation or early precursor T cell phenotype) is far behind the average. Innovative strategies in medical attendance provide better clinical outcomes for them: complete gene diagnostics, molecularly targeted anticancer treatment, immuno-oncology and immune cell therapy. The number of genes with identified alterations in leukemic lymphoblasts is over thirty and their pathobiologic role is only partly clear. There are known patient groups where the use of specific drugs is based on gene expression profiling (e.g., tyrosine kinase inhibitors in Philadelphia-like B-cell ALL). The continuous assessment of minimal residual disease became a routine due to the determination of a leukemia-associated immunophenotype by flow cytometry or a sensitive molecular marker by molecular genetics at diagnosis. Epitopes of cluster differentiation antigens on blast surface (primarily CD19, CD20 and CD22 on malignant B cells) can be attacked by monoclonal antibodies. Moreover, antitumor immunity can be strengthened utilizing either cell surface markers (bispecific T cell engagers, chimeric antigen receptor T cell therapy) or tumor-specific immune cells (immune checkpoint inhibitors). This review gives an insight into current knowledge in these innovative therapeutic directions. Orv Hetil. 2018; 159(20): 786–797.
A 2-es típusú diabetes mellitus prevalenciájának változása szájüregi carcinomás betegek körében
Authors: Bányai Dorottya , Végh Dániel , Vaszilkó Mihály , Végh Ádám , Ács Lili , Rózsa Noémi , Hermann Péter , Németh Zsolt , Ujpál Márta
Published: May 2018

Abstract:

Introduction: Data proves that Hungary has a leading role in the statistics of oral cancer and patients living with type 2 diabetes. Aim: Our aim was to understand the statistical correlation between oral cancer and metabolic disorder (diabetes mellitus and impaired fasting glucose) due to the valuable data from the Semmelweis University. Method: We analyzed the data of 835 patients diagnosed with malignant oral cancer and 587 tumor-free control patients. We investigated the incidence and location of oral cancer among patients living with diabetes, and compared these datasets with our previous data from 14 years earlier. Results: We found that in oral cancer patients, 26.1% had diabetes and 20.8% had impaired fasting glucose; in the control group these ratios were 10.8% and 11.1%. This difference is significant (p<0.05). 14 years ago in the tumor group 14.6%, in the control group 5.6% had diabetes, while 9.7% and 5.5% had impaired fasting glucose. Lip cancer had the biggest incidence. Conclusions: The rise of type 2 diabetes in the tumor group was significant. This could be a burden for the health care system. We want to highlight the importance of interdisciplinary cooperation between health care professionals. Orv Hetil. 2018; 159(20): 803–807.
Új nemzetközi konszenzusnyilatkozat a száraz szem definíciójáról, felosztásáról, etiológiájáról, diagnosztikájáról és terápiájáról
Authors: Berta András , Tóth-Molnár Edit , Csutak Adrienne
Published: May 2018

Abstract:

Ten years have passed since the publication of the DEWS Report that summarized the information based on scientific literature concerning dry eye disease. Hundreds of papers have been published since then and time has come for a new summary. Organized by the Tear Film & Ocular Surface Society, 12 working groups summerized former and recent data. The DEWS II Report was created. The authors of the present publication summarize the most important changes in definition, classification, diagnostics, and therapy concerning dry eye disease. They also disclose the relevant changes on which the non-ophthalmologist specialists have to be informed. The DEWS II Report published by TFOS consists of 11 chapters. Completely new chapters deal with the role of sensation/pain and iatrogenic dry eyes. Orv Hetil. 2018; 159(20): 775–785.
Stroke-prevenció időskorban: az edoxabán hatékonysága és biztonságossága idős betegekben az ENGAGE AF vizsgálat eredményei alapján
Authors: Márk László
Published: May 2018

Abstract:

Atrial fibrillation is the most common clinically relevant arrhythmia frequently causing systemic thromboembolic events. Traditionally vitamin K antagonists had been used for decades to prevent these events. The emerging of the new direct anticoagulants has revolutionized this treatment and a gradual growth and extensive spread of usage is expected. The latest one approved in Hungary, edoxaban, is a factor Xa inhibitor. Once-daily administration and favourable safety profile are major benefits of this drug. In a large clinical study with a high number of patients it proved to be at least as effective as warfarin in the prevention of stroke and systemic embolization while causing significantly less major bleedings. As the incidence of atrial fibrillation increases with age, the observation that, compared with the other direct oral anticoagulants, the administration of edoxaban in the elderly has a favourable net clinical benefit (in the rate of prevented thromboembolic events and the number of caused bleedings) may have a great importance. Orv Hetil. 2018; 159(20): 798–802.
Sisbiota-Mar protocol - benthic community sampling v1
Authors: W Aued Anaide , O. Longo Guilherme
Published: May 2018

The Sisbiota-mar photoquadrat survey aims to quantify the benthic cover of horizontal reef surfaces using photography and subsequent image analysis, in a manner that is directly comparable across geographies. Our survey method employs 2m2 horizontal surfaces of reef area at 1-7 meters (shallow) and 8-15 meters (deep). At each locality, between one and five reef sites were assessed (but most of them had at least three sampled sites). The 2m2 horizontal surfaces of reef area were at least 2 meters apart and haphazardly selected (avoiding sand patches). On each 2m2 reef area, the benthic community was assessed by a set of five 25x25 cm photoquadrats.
Transfection of Capsaspora owczarzaki using calcium-phosphate precipitation v1
Authors: Parra Acero Helena , Ros Núria , Perez-Posada Alberto , Kozyczkowska Aleksandra , R. Najle Sebastián
Published: May 2018

This is a protocol to transiently transfect Capsaspora owczarzaki, a unicellular eukaryote
Adversidade na infância e objetivos de vida em adultos
Authors: Silva Maria de Fátima Marques , Mota Catarina Pinheiro
Published: May 2018

O presente estudo tem como objetivo analisar a contribuição das experiências adversas na infância no desenvolvimento de objetivos de vida na adultícia, sendo testado o papel mediador da vinculação aos pais na associação anterior. A amostra foi constituída por 511 indivíduos, com idades compreendidas entre os 25 e os 50 anos de idade. Para a recolha dos dados foram utilizados questionários de autorrelato. Os resultados apontam para um efeito preditor negativo das experiências adversas na infância face aos objetivos de vida enquanto adultos. Observou-se, ainda, que a qualidade da vinculação aos pais tem um papel mediador na associação entre as experiências adversas na infância e os objetivos de vida na adultícia.
Örgüt Kültürü ve İklimi Çalışmalarının Sistematik İncelemesi: Bir İçerik Analizi
Authors: SEZGİN Ferudun , SÖNMEZ Emre
Published: May 2018

Bu araştırmanın amacı, Türkiye’de 2000-2016 yılları
arasında eğitim bilimleri alanında yayımlanan örgüt kültürü ve örgüt iklimi
çalışmalarını belirli ölçütlere göre incelemek ve araştırmaların ne tür bir
eğilim gösterdiğini belirlemektir. Bu amaç doğrultusunda, araştırmada betimsel
içerik analizi yöntemi kullanılmıştır. Araştırma kapsamında, belirlenen
ölçütlere uyan 354 çalışmaya erişilmiştir. Her bir çalışma, araştırmacılar
tarafından geliştirilen kodlama formuna göre derlenmiş ve kategorik çözümleme
tekniğiyle analiz edilmiştir. Araştırma sonuçlarına göre; örgüt kültürü ve
iklimi çalışmaları çalışma konu alanları, yayım yılları, yazar sayıları, yayım
türleri, çalışmaların gerçekleştirildiği örneklem bölgesi, eğitim kademesi ve
kullanılan metodoloji açısından benzer eğilimler göstermiştir. İlgili alan
yazına göre farklı etimolojik, epistemolojik ve metodolojik temellere sahip
olmalarına rağmen bu iki araştırma alanının benzer yaklaşımlarla çalışıldığı
görülmektedir. Ulusal tarihsel süreç incelendiğinde, bu araştırma konularına
yönelik araştırmacıların ilgisinin artarak devam ettiği söylenebilir.
Histological Alterations from Condyle Repositioning with Functional Appliances in Rats
Authors: Kim Ji-Youn , Jue Seong-Suk , Bang Hee-Joon , Christine Hong , Moon Jong-il , Nakatsuka Michiko , Kumabe Shunji , Owtad Payam , Park Jae Hyun , Shin Je-won
Published: May 2018

Objective: This study was designed to assess the morphological and histological alterations of the condyle of rats undergoing forward mandibular repositioning via functional appliance.

Materials and Methods: Functional appliances were mounted onto the upper jaws of rats. Morphological analysis was conducted on micro-CT images of sacrificed animals. Histological changes in condyle were examined by immunohistochemistry using proliferating cell nuclear antigen (PCNA), matrix metalloproteases (MMPs), vascular endothelial growth factor (VEGF), tissue inhibitors of matrix metalloproteinases (TIMP-1), interleukin 1b (IL-1β), Aggrecan and Type II collagen. Osteoclast activity was identified by tartrate-resistant acid phosphatase (TRAP) staining.

Results: Morphological analysis confirmed the forward positioning of the condyles of rats by the appliance, but the position gradually returned to normal on days 14 after treatment. An increase in PCNA positive cells was observed in the posterior region of the condyles on days 7, whereas PCNA positive cells decreased in the anterior region. Aggrecan and Type II collagen localization increased in the posterior region throughout the entire period, but decreased in the anterior region on days 14. In both regions, IL-1β and VEGF localization was significantly increased for 14 days while MMPs localization was evident throughout the entire period. The TRAP positive cells were significantly elevated on days 3 and 7.

Conclusions: These results suggest that the functional appliance therapy induces significant morphological and histological changes in the anterior and posterior regions of the condyle and subsequently causes adaptive cellular functions such as chondrocyte differentiation and cartilage matrix formation.
Passive Observer Instruction on Parental Satisfaction in a Dental Setting
Authors: Rodriguez Hilma K , Webman Mark S , Arevalo Oscar , Roldan Rosie , Saman Daniel M
Published: May 2018

Purpose: To assess the effect of a single pre-operative instruction given to parents to be a passive observer on satisfaction with their child's dental visit. Study design: Parents of 105 healthy three to nine year-old patients presenting for their first restorative appointment were randomly assigned to the test or control group. The former received an oral instruction at the beginning of the appointment from the treating dentist to be a passive observer while the latter received a mock instruction. The dentist assessed whether the parent remained a passive observer during the visit. Parents completed a survey assessing satisfaction with their child's dental visit. Results: More parents were rated as passive in the test group than in the control group, 67.3% vs. 32.1%, (P<0.01). However, no statistically significant difference was found in parental satisfaction between the test and the control group. Conclusion: Asking parents to act as passive observers may help preserve the advantages of parental presence in the operatory while eliminating many of the disadvantages. A single preoperative instruction given orally by the treating dentist to be a passive observer was effective and did not lead to a reduction in parental satisfaction.
Índiz d'asturianidá de testos falaos: un ensayu
Authors: De Andrés Díaz Ramón
Published: May 2018

Ramón d’Andrés (Universidad de Oviedo, Seminariu de Filoloxía Asturiana), randresd@uniovi.es),  «Índice de asturianidad de textos hablados: un ensayo».La mezcla de asturiano y castellano plantea el problema de la frontera lectal entre ambas lenguas: ¿qué es hablar asturiano? Si se adopta un enfoque subjetivo, la respuesta depende de las percepciones del hablante. Si se adopta un enfoque objetivo, la respuesta depende de un análisis cuantitativo realizado por el lingüista. Aquí se propone un procedimiento objetivo de recuento aplicable a textos o muestras concretas de habla. Se hace el ensayo con dos textos orales, uno rural de Cabranes y otro urbano de Gijón. Los resultados son muy elocuentes sobre la tipificación de ambos textos.Palabras clave: asturiano, castellano, mezcla de lenguas, análisis cuantitativo, rasgos diferenciales. Ramón d’Andrés (University of Oviedo, Seminariu de Filoloxía Asturiana ‒ Asturian Philology Seminar), randresd@uniovi.es),  «Asturian laguage index in spoken texts: an essay».The mixture of Asturian and Spanish raises the problem of the lectal boundary between both languages: what is to speak Asturian? If a subjective approach is adopted, the answer depends on the perceptions of the speaker. If an objective one, the answer depends on a quantitative analysis by the linguist. Here is proposed an objective procedure count applicable to texts or specific samples of speech. This trial is applied to two oral texts, one rural from Cabranes and the other urban from Gijón. The results are very eloquent about the classification of both texts.Key words: Asturian, Spanish, language mixing, quantitative analysis, differential features.
Credit and the housing boom in Malaysa: a come back?
Authors: Mohd Daud Siti Nurazira , Ahmad Abd Halim , Podivinsky Jan M
Published: May 2018

This article investigates the existence of credit and housing booms in the Malaysian economy, with high levels of household indebtedness. The results reveal that both the credit boom and the housing boom exist and imply the fragility of the financial sector of the economy.
Análisis de las expectativas del profesorado novel sobre su futura labor docente
Authors: Montilla Coronad Maria Del Valle Cecilia , Maraver-López Pablo , Romero Oliva Cristina , Martín Montilla Ariadna
Published: May 2018

Dado el carácter cambiante de las leyes educativas y los cambios prescriptivos en el acceso a la profesión docente, esta investigación se plantea conocer y describir las distintas concepciones del profesorado novel que cursó el Máster de Profesorado, durante tres cursos académicos consecutivos en la Universidad de Huelva. Los objetivos planteados tratan de desvelar los planteamientos didácticos de 323 titulados universitarios, así como sus expectativas profesionales sobre la docencia. Se trata de conocer cómo piensan plantear sus objetivos docentes, las actividades de clase, la evaluación así como los recursos que consideran utilizar en su quehacer profesional. La metodología es transversal. Una de las conclusiones más interesantes es que una mayoría del profesorado novel se plantea metodologías innovadoras y participativas, encuadrándose en un paradigma constructivista que permita, a través de los variados conocimientos previos del alumnado, progresar en función de sus particularidades...
RIGHT AND WRONG FROM THE PERSPECTIVE OF 8- AND 12-YEAR-OLD CHILDREN: AN EXPLORATORY ANALYSIS
Authors: Ammann Kira
Published: May 2018

Understanding rights not only means knowing what is permitted by law and what is not, but also being aware of and knowing one’s own rights as a human being. This analysis explores how children understand right and wrong, how they gain moral orientations and a sense of justice, and whether they are aware of human rights and children’s rights, and if so to what extent. Twelve children aged either 8 or 12 participated in an interview on a dilemma story, as pioneered by Kohlberg, and were also asked about children’s rights and human rights. Qualitative content analysis showed that the majority used moral judgements based on fairness and justice, taking the view that behaviour that is wrong should be duly punished. Eight children were able to make substantive statements on human rights; of the eight, three also had some knowledge of children’s rights. There were differences between the types of arguments used by the two age groups. There were also some differences between boys and girls, but they were negligible. In German-speaking countries there is little empirical research on children’s rights. Few studies have focused on the topic of human rights from the perspective of educational science, and there is also little research on moral concepts and children’s rights. What follows is therefore a first attempt to link two neglected research topics.