bluuebunny/crossref_metadata_2025 huggingface dataset:
Water‐facilitated targeted repair of degraded cathodes for sustainable lithium‐ion batteries
Authors: Lin Jiao , Zhang Xiaodong , Li Zhujie , Fan Ersha , Lv Xiaowei , Chen Renjie , Wu Feng , Li Li
Published: March 2024

Directly repairing end‐of‐life lithium‐ion battery cathodes poses significant challenges due to the diverse compositions of the wastes. Here, we propose a water‐facilitated targeted repair strategy applicable to various end‐of‐life batches and cathodes. The process involves initiating structural repair and reconstructing particle morphology in degraded LiMn2O4 (LMO) through an additional thermal drive post‐ambient water remanganization, achieving elemental repair. Compared to solid‐phase repair, the resulting LMO material exhibits superior electrochemical and kinetic characteristics. The theoretical analysis highlights the impact of Mn defects on the structural stability and electron transfer rate of degraded materials. The propensity of Mn ions to diffuse within the Mn layer, specifically occupying the Mn 16d site instead of the Li 8a site, theoretically supports the feasibility of ambient water remanganization. Moreover, this method proves effective in the relithiation of degraded layered cathode materials, yielding single crystals. By combining low energy consumption, environmental friendliness, and recyclability, our study proposes a sustainable approach to utilizing spent batteries. This strategy holds the potential to enable the industrial direct repair of deteriorated cathode materials.
Enhanced recovery after endoscopic sinus surgery: Establishing comprehensive protocols for improvement of perioperative patient care
Authors: Barrette Louis‐Xavier , Cohen William G. , Chao Tiffany , Douglas Jennifer E. , Kearney James , Thaler Erica , Kohanski Michael A. , Adappa Nithin , Palmer James N. , Rajasekaran Karthik
Published: March 2024

Objectives

Enhanced recovery after surgery (ERAS) protocols for endoscopic sinus surgery (ESS) have not been widely implemented, and a critical review of ERAS recommendations and a comprehensive analysis of the supporting literature has not been undertaken. We describe an ESS ERAS protocol including key perioperative interventions for patients undergoing ESS and assess the available evidence.

Data Sources

A search was conducted of all relevant ERAS literature in otorhinolaryngology, anesthesia, and surgery using Medline (via PubMed), and Scopus. Keywords included “endoscopic sinus surgery,” “sinus surgery,” “FESS,” and “ESS” for each area of intervention. Where applicable, the authors considered high‐level evidence for recommendations devised for patient cohorts in otorhinolaryngology not undergoing ESS, as well as cohorts undergoing surgical procedures for which ERAS protocols have been extensively evaluated.

Methods

Studies received grades of “low,” “moderate,” or “high” quality evidence based on the Oxford Centre for Evidence‐Based Medicine criteria. Each intervention was subsequently assigned a grade of “strong,” “weak,” or “conditional” based on the available evidence.

Results

Strong recommendations include comprehensive patient education and counseling, minimization of preoperative fasting, application of topical/local anesthetics and vasoconstrictors, use of total intravenous anesthesia, avoidance of pharyngeal packing, and use of postoperative nasal irrigation and multimodal analgesia. Conditional recommendations include antibiotic prophylaxis. Weak recommendations include perioperative venous thromboembolism prophylaxis, controlled hypotension, and use of postoperative nasal packing/dressing.

Conclusion

A comprehensive ERAS protocol for ESS can include a variety of high yield, evidence‐based interventions that would likely improve surgical outcomes and patient satisfaction.
The spectrum of pre‐mRNA splicing in autism
Authors: Engal Eden , Zhang Zhenwei , Geminder Ophir , Jaffe‐Herman Shiri , Kay Gillian , Ben‐Hur Asa , Salton Maayan
Published: March 2024

Disruptions in spatiotemporal gene expression can result in atypical brain function. Specifically, autism spectrum disorder (ASD) is characterized by abnormalities in pre‐mRNA splicing. Abnormal splicing patterns have been identified in the brains of individuals with ASD, and mutations in splicing factors have been found to contribute to neurodevelopmental delays associated with ASD. Here we review studies that shed light on the importance of splicing observed in ASD and that explored the intricate relationship between splicing factors and ASD, revealing how disruptions in pre‐mRNA splicing may underlie ASD pathogenesis. We provide an overview of the research regarding all splicing factors associated with ASD and place a special emphasis on five specific splicing factors—HNRNPH2, NOVA2, WBP4, SRRM2, and RBFOX1—known to impact the splicing of ASD‐related genes. In the discussion of the molecular mechanisms influenced by these splicing factors, we lay the groundwork for a deeper understanding of ASD's complex etiology. Finally, we discuss the potential benefit of unraveling the connection between splicing and ASD for the development of more precise diagnostic tools and targeted therapeutic interventions.

This article is categorized under:

RNA in Disease and Development > RNA in Disease

RNA Evolution and Genomics > RNA and Ribonucleoprotein Evolution

RNA Evolution and Genomics > Computational Analyses of RNA

RNA‐Based Catalysis > RNA Catalysis in Splicing and Translation
TBA equations and exact WKB analysis in deformed supersymmetric quantum mechanics
Authors: Ito Katsushi , Shu Hongfei
Published: March 2024

Abstract

We study the spectral problem in deformed supersymmetric quantum mechanics with polynomial superpotential by using the exact WKB method and the TBA equations. We apply the ODE/IM correspondence to the Schrödinger equation with an effective potential deformed by integrating out the fermions, which admits a continuous deformation parameter. We find that the TBA equations are described by the ℤ4-extended ones. For cubic superpotential corresponding to the symmetric double-well potential, the TBA system splits into the two D3-type TBA equations. We investigate in detail this example based on the TBA equations and their analytic continuation as well as the massless limit. We find that the energy spectrum obtained from the exact quantization condition is in good agreement with the diagonalization approach of the Hamiltonian.
Molecular mechanisms and regulation of recombination frequency and distribution in plants
Authors: Zou Meilin , Shabala Sergey , Zhao Chenchen , Zhou Meixue
Published: March 2024

Key message

Recent developments in understanding the distribution and distinctive features of recombination hotspots are reviewed and approaches are proposed to increase recombination frequency in coldspot regions.

Recombination events during meiosis provide the foundation and premise for creating new varieties of crops. The frequency of recombination in different genomic regions differs across eukaryote species, with recombination generally occurring more frequently at the ends of chromosomes. In most crop species, recombination is rare in centromeric regions. If a desired gene variant is linked in repulsion with an undesired variant of a second gene in a region with a low recombination rate, obtaining a recombinant plant combining two favorable alleles will be challenging. Traditional crop breeding involves combining desirable genes from parental plants into offspring. Therefore, understanding the mechanisms of recombination and factors affecting the occurrence of meiotic recombination is important for crop breeding. Here, we review chromosome recombination types, recombination mechanisms, genes and proteins involved in the meiotic recombination process, recombination hotspots and their regulation systems and discuss how to increase recombination frequency in recombination coldspot regions.
Manifestations of xenophobia in AI systems
Authors: Tomasev Nenad , Maynard Jonathan Leader , Gabriel Iason
Published: March 2024

Xenophobia is one of the key drivers of marginalisation, discrimination, and conflict, yet many prominent machine learning fairness frameworks fail to comprehensively measure or mitigate the resulting xenophobic harms. Here we aim to bridge this conceptual gap and help facilitate safe and ethical design of artificial intelligence (AI) solutions. We ground our analysis of the impact of xenophobia by first identifying distinct types of xenophobic harms, and then applying this framework across a number of prominent AI application domains, reviewing the potential interplay between AI and xenophobia on social media and recommendation systems, healthcare, immigration, employment, as well as biases in large pre-trained models. These help inform our recommendations towards an inclusive, xenophilic design of future AI systems.
Farmers’ Willingness to Participate in a Carbon Sequestration Program – A Discrete Choice Experiment
Authors: Block Julia B. , Danne Michael , Mußhoff Oliver
Published: March 2024

Farmers can counteract global warming by drawing carbon dioxide from the air into agricultural soils by building up humus. Humus programs were developed to motivate farmers for even more humus formation (= carbon sequestration) through an additional financial incentive. These programs are still at an early stage of development, which is why the number of participating farmers and research work is still low. This study is the first to analyze the willingness of German farmers to participate in hypothetical humus programs. The results of a discrete choice experiment show that a (higher) threshold for the payout of the premium, regional (rather than field-specific) reference values, and the risk of repayment clearly discourage farmers from participating. Program providers must more than double the premium (set at around 240 € per hectare and 0.1% humus increase) to maintain farmers’ willingness to participate despite a payout threshold. Regional reference values and an additional premium/repayment system would lead to an increase in the premium of around 20 € per hectare in order to keep the willingness to participate at the same level. The motivation to build up humus, the desire to maximize subsidies, and a higher livestock density have a positive influence on farmers’ decision to participate. Farm size and risk attitude have an impact on farmers’ preferences for program design. The study is relevant for policymakers and non-governmental organizations concerned with carbon management, as our findings highlight pathways for efficient, targeted designs of humus programs and carbon sequestration policies.
Totally intracorporeal colorectal anastomosis (TICA) versus classical mini-laparotomy for specimen extraction, after segmental bowel resection for deep endometriosis: a single-center experience
Authors: Ianieri Manuel Maria , De Cicco Nardone Alessandra , Greco Pierfrancesco , Carcagnì Antonella , Campolo Federica , Pacelli Fabio , Scambia Giovanni , Santullo Francesco
Published: March 2024

Purpose

The surgical approach to bowel endometriosis is still unclear. The aim of the study is to compare TICA to conventional specimen extractions and extra-abdominal insertion of the anvil in terms of both complications and functional outcomes.

Methods

This is a single-center, observational, retrospective study conducted enrolling symptomatic women underwent laparoscopic excision of deep endometriosis with segmental bowel resection between September 2019 and June 2022. Women who underwent TICA were compared to classical technique (CT) in terms of intra- and postoperative complications, moreover, functional outcomes relating to the pelvic organs were assessed using validated questionnaires [Knowles-Eccersley-Scott-Symptom (KESS) questionnaire and Gastro-Intestinal Quality of Life Index (GIQLI)] for bowel function. Pain symptoms were assessed using Visual Analogue Scale (VAS) scores.

Results

The sample included 64 women. TICA was performed on 31.2% (n = 20) of the women, whereas CT was used on 68.8% (n = 44). None of the patients experienced rectovaginal, vesicovaginal, ureteral or vesical fistula, or ureteral stenosis and uroperitoneum, and in no cases was it necessary to reoperate. Regarding the two surgical approaches, no significant difference was observed in terms of complications. As concerns pain symptoms at 6-month follow-up evaluations on stratified data, except for dysuria, all VAS scales reported showed significant reductions between median values, for both surgery interventions. As well, significant improvements were further observed in KESS scores and overall GIQLI. Only the GIQLI evaluation was significantly smaller in the TICA group compared to CT after the 6-month follow-up.

Conclusions

We did not find any significant differences in terms of intra- or post-operative complications compared TICA and CT, but only a slight improvement in the Gastro-Intestinal Quality of Life Index in patients who underwent the CT compared to the TICA technique.
Identification and validation of neutrophils-related subtypes and prognosis model in triple negative breast cancer
Authors: Li Shanqi , Qian Yuzhou , Xie Wanchen , Li Xinyu , Wei Jiaying , Wang Long , Ren Guosheng , Yin Xuedong
Published: March 2024

Background

Neutrophils are considered to be crucial players in the initiation and progression of cancer. However, the complex relationship between neutrophils and cancer prognosis remains elusive, mainly due to the significant plasticity and diversity exhibited by these immune cells.

Methods

As part of our thorough investigation, we examined 38 Neutrophils-Related Genes (NRGs) and the associated copy number variations (CNV), somatic mutations, and gene expression patterns in relation to triple negative breast cancer (TNBC). The interactions between these genes, their biological roles, and their possible prognostic significance were then examined. With the NRGs as our basis, we applied Lasso and Cox regression analyses to create a predictive model for overall survival (OS). Furthermore, TNBC tissue and a public database were used to assess changes in MYO1D expression (MYO1D is characterized as a member of the myosin-I family, a group of motor proteins based on actin), its connection to neutrophil infiltration, and the clinical importance of MYO1D in TNBC.

Results

Four neutrophil-related genes were included in the development of a prognostic model based on neutrophils. The model was further shown to be an independent predicted factor for overall survival by multivariate Cox regression analysis. According to this study, neutrophil subtype B as well as gene subtype B, were associated with activated cancer immunity and poor prognosis of TNBC patients. Furthermore, considering that poor OS was linked to increased MYO1D expression, MYO1D was increased in TNBC tissues and associated with neutrophil infiltration. In vitro experiments also confirmed that MYO1D facilitates breast cancer invasion and metastasis.

Conclusion

Based on the degree of gene expression linked to neutrophils, a unique prognostic model was created. MYO1D could be a potential prognostic biomarker in TNBC patients and also a prospective target for therapy.
Advancing the resource nexus concept for research and practice
Authors: Brouwer Floor , Caucci Serena , Karthe Daniel , Kirschke Sabrina , Madani Kaveh , Mueller Andrea , Zhang Lulu , Guenther Edeltraud
Published: March 2024

The nexus concept has considerably matured during the past decade. Numerous literature reviews have significantly contributed to taking stock of the advancements in knowledge and tool development to improve science-policy support on highly connected and interdependent resources. However, literature reviews often focus on specific sector-based nexus concepts (such as water-energy-food nexus) and analyses (such as environmental assessment, technical tools, or the management and policy dimension). Therefore, a comprehensive understanding of the actual nexus and the resources it builds upon still needs to be improved. This paper aims to test the validity of the nexus construct for research and practice. Based on a systematic review of reviews, including 62 nexus-related review papers and subsequent consultation of some sixty nexus experts, we suggest a robust but flexible approach to advancing the Resource Nexus for research and practice. In doing so, the knowledge provided by nexus research may provide more substantial support to decision-makers when designing and implementing policies for the sustainable management of environmental resources.
Analyzing the 20-year declining trend of hospital length-of-stay in European countries with different healthcare systems and reimbursement models
Authors: Golinelli Davide , Sanmarchi Francesco , Toscano Fabrizio , Bucci Andrea , Nante Nicola
Published: March 2024

The study aims to investigate the last 20-year (2000–2019) of hospital length of stay (LOS) trends and their association with different healthcare systems (HS) among 25 European countries. A panel dataset was created using secondary data from Eurostat and Global Burden of Disease study databases, with dependent and control variables aggregated at the national level over a period of 20 years. A time trend analysis was conducted using a weighted least squares model for panel data to investigate the association between LOS, HS models [National Health Service (NHS), National Health Insurance, Social Health Insurance (SHI), and Etatist Social Health Insurance], healthcare reimbursement schemes [Prospective Global Budget (PGB), Diagnosis Related Groups (DRG), and Procedure Service Payment (PSP)], and control variables. The study showed a reduction of average LOS from 9.20 days in 2000 to 7.24 in 2019. SHI was associated with a lower LOS compared to NHS (b = − 0.6327, p < 0.05). Both DRG (b = 1.2399, p < 0.05) and PSP (b = 1.1677, p < 0.05) reimbursement models were positively associated with LOS compared to PGB. Our results confirmed the downward trend of LOS in the last 20 years, its multifactorial nature, and the influence of the SHI model of HS. This could be due to the financial incentives present in fee-for-service payment models and the role of competition in creating a market for healthcare services. These results offer insight into the factors influencing healthcare utilization and can inform the design of more effective, efficient, and sustainable HS.
Inventory of School Supports-Parent Report (ISS-PR): Development and Validation with Military-Connected Families
Authors: Steggerda Jake C. , Cavell Timothy A. , Nicholson Juliann H. , Drew Alison L. , Herrera Carla , Gaffney Debby , Slep Amy M. Smith , Lorber Michael F. , Spencer Renée
Published: March 2024

Tools that assess school supports for highly mobile, military-connected students are lacking. This study describes the development and preliminary validation of the Inventory of School Supports-Parent Report (ISS-PR). Participants were 433 parents (74% female; 62.5% White, 12% Black, 6.5% Asian, 5.5% Pacific Islander, 4% Native American, and 9.5% bi/multiracial; 19% Latinx) of students (grades 3–5) from families with an active-duty military parent. Parents completed the ISS-PR and rated: (a) how welcoming schools were toward military-connected families; (b) parent-teacher relationship quality; and (c) satisfaction with their child’s school. We created three proportional index composite scores: a 26-item school supports score, a 13-item parent-focused supports score, and a 13-item child-focused supports score. Results supported the ISS-PR’s psychometric properties: summary scores were positively linked to parent-teacher relationship quality, school welcoming, and parent satisfaction with the school. We also found evidence for test-retest reliability for parents completing the inventory with students who had either moved schools or remained in their previous schools. Future studies could use the ISS-PR to assess whether parents’ perceptions of the availability and importance of school supports for military-connected families are related to other constructs such as overall school climate, student academic performance, and socioemotional functioning. Schools could use the inventory to determine which supports could potentially have the greatest impact for military-connected families and to what extent parents are aware of the supports schools offer.
Solving Maxmin Optimization Problems via Population Games
Authors: Balter Anne G. , Schumacher Johannes M. , Schweizer Nikolaus
Published: March 2024

Population games are games with a finite set of available strategies and an infinite number of players, in which the reward for choosing a given strategy is a function of the distribution of players over strategies. The paper shows that, in a certain class of maxmin optimization problems, it is possible to associate a population game to a given maxmin problem in such a way that solutions to the optimization problem are found from Nash equilibria of the associated game. Iterative solution methods for maxmin optimization problems can then be derived from systems of differential equations whose trajectories are known to converge to Nash equilibria. In particular, we use a discrete-time version of the celebrated replicator equation of evolutionary game theory, also known in machine learning as the exponential multiplicative weights algorithm. The resulting algorithm can be viewed as a generalization of the Iteratively Reweighted Least Squares (IRLS) method, which is well known in numerical analysis as a useful technique for solving Chebyshev function approximation problems on a finite grid. Examples are provided to show the use of the generalized IRLS method in collective investment and in decision making under model uncertainty.
Patient preference on once-daily oral versus injectable androgen deprivation therapy for Asian patients with advanced prostate cancer
Authors: Wong Ho-Ming Chris , Cheung Bernice Cheuk-Sin , Yuen Violet Wai-Fan , Teoh Jeremy Yuen-Chun , Chiu Peter Ka-Fung , Ng Chi-Fai
Published: March 2024

Purpose

The study aimed at investigating prostate cancer patients’ choice of androgen deprivation treatment (ADT) and possible factors that would affect their preferences of ADT.

Methods

This was a single-centre cross-sectional study investigating the usage and preferences of ADT. Consecutives prostate cancer patients who were receiving injectable luteinizing hormone-releasing hormone (LHRH) agonist or antagonist were recruited from the prostate cancer clinic in a tertiary academic hospital. Patients who received bilateral orchidectomy or those who could not consent to the study were excluded. Disease characteristics, treatment information and patient background were documented. The survey collected information related to their change in ADT regimen, preferences on drug usage (routes and frequency of administration) and their reasons. A hypothetical set of three drug formularies was designed. Questions regarding patient preference and the contributing reasons raised in the format of questionnaire.

Results

100 patients completed the survey. Most patients started with more frequent injections (3-monthly, 54%; 1-monthly, 38%) and switched to 6-monthly injections (89%) at the time of the survey. Primary reasons for the change were healthcare opinion (72%) and less frequent treatment (51%).

Three options of ADT (oral daily, 1-monthly and 6-monthly injection) with the same efficacies and side effect profile were offered: 61% preferred 6-monthly injection, 1% preferred 1-monthly injection and 38% preferred oral regimen. When patients were informed of lower cardiovascular side effects in 1-monthly injection or daily oral drug, patients’ preference was 56% (6-monthly), 6% (1-monthly), and 39% (oral). Patients with polypharmacy (more than 5 regular medications) were more inclined to choose injections (p = 0.025). Patient age, educational background, employment status, marriage status and disease status were not found to be statistically significant contributing factors to patient preference.

Conclusion

6-monthly ADT injection was the preferred ADT despite greater cardiovascular risks. Among 1-monthly or daily oral LHRH antagonist, more patients prefer oral option. Convenience factor was highly valued.
Data-Driven Accelerated Parameter Identification for Chaboche-Type Visco-Plastic Material Models to Describe the Relaxation Behavior of Copper Alloys
Authors: Morand L. , Norouzi E. , Weber M. , Butz A. , Helm D.
Published: March 2024

Background

Calibrating material models to experimental measurements is crucial for realistic computational analysis of components. For complex material models, however, optimization-based identification procedures can become time-consuming, particularly if the optimization problem is ill-posed.

Objective

The objective of this paper is to assess the feasibility of using machine learning to identify the parameters of a Chaboche-type material model that describes copper alloys. Specifically, we apply and analyze this identification approach using short-term uniaxial relaxation tests on a C19010 copper alloy.

Methods

A genetic algorithm forms the basis for identifying the parameters of the Chaboche-type material model. The approach is accelerated by replacing the numerical simulation of the experimental setup by a neural network surrogate. The neural networks-based approach is compared against a classic approach using both, synthetic and experimental data.

Results

The results show that on the one hand, a sufficiently accurate identification of the material model parameters can be achieved by a classic but time-consuming genetic algorithm. On the other hand, it is shown that machine learning enables a much more time-efficient identification procedure, however, suffering from the ill-posedness of the identification problem.

Conclusion

Compared to classic parameter identification approaches, machine learning techniques can significantly accelerate the identification procedure for parameters of Chaboche-type material models with acceptable loss of accuracy.
Establishing healthy longevity clinics in publicly funded hospitals
Authors: Bonnes Sara L. R. , Strauss Tzipora , Palmer Allyson K. , Hurt Ryan T. , Island Louis , Goshen Abigail , Wang Laureen Y. T. , Kirkland James L. , Bischof Evelyne , Maier Andrea B.
Published: March 2024

Healthy longevity medicine integrates geroscience and other disciplines into clinical settings, aiming to optimize health throughout one’s lifespan. Multiple factors have led to increased consumer engagement, with private clinics currently meeting the demand for guidance to improve healthy longevity. The establishment of healthy longevity clinics in publicly funded hospitals is a significant development, making longevity-focused healthcare more accessible. These clinics rely on multidisciplinary teams of physicians and allied health professionals. Diagnostics involve comprehensive evaluations of medical history, physical examinations, and various clinical tests to detect early signs of age-related functional decline. Interventions in healthy longevity medicine encompass lifestyle modifications, supplements, repurposed drugs, and social and environmental interventions. Collaboration with research institutions and industry partners is crucial for advancing healthy longevity medicine and creating standardized protocols. In this article, we review the process of creating healthy longevity clinics in public hospitals to ensure the best possible care for individuals pursuing healthy longevity.
Computed tomography-based 3D convolutional neural network deep learning model for predicting micropapillary or solid growth pattern of invasive lung adenocarcinoma
Authors: Huo Jiwen , Min Xuhong , Luo Tianyou , Lv Fajin , Feng Yibo , Fan Qianrui , Wang Dawei , Ma Dongchun , Li Qi
Published: March 2024

Purpose

To investigate the value of a computed tomography (CT)-based deep learning (DL) model to predict the presence of micropapillary or solid (M/S) growth pattern in invasive lung adenocarcinoma (ILADC).

Materials and Methods

From June 2019 to October 2022, 617 patients with ILADC who underwent preoperative chest CT scans in our institution were randomly placed into training and internal validation sets in a 4:1 ratio, and 353 patients with ILADC from another institution were included as an external validation set. Then, a self-paced learning (SPL) 3D Net was used to establish two DL models: model 1 was used to predict the M/S growth pattern in ILADC, and model 2 was used to predict that pattern in ≤ 2-cm-diameter ILADC.

Results

For model 1, the training cohort’s area under the curve (AUC), accuracy, recall, precision, and F1-score were 0.924, 0.845, 0.851, 0.842, and 0.843; the internal validation cohort’s were 0.807, 0.744, 0.756, 0.750, and 0.743; and the external validation cohort’s were 0.857, 0.805, 0.804, 0.806, and 0.804, respectively. For model 2, the training cohort’s AUC, accuracy, recall, precision, and F1-score were 0.946, 0.858, 0.881,0.844, and 0.851; the internal validation cohort’s were 0.869, 0.809, 0.786, 0.794, and 0.790; and the external validation cohort’s were 0.831, 0.792, 0.789, 0.790, and 0.790, respectively. The SPL 3D Net model performed better than the ResNet34, ResNet50, ResNeXt50, and DenseNet121 models.

Conclusion

The CT-based DL model performed well as a noninvasive screening tool capable of reliably detecting and distinguishing the subtypes of ILADC, even in small-sized tumors.
Value of virtual non-contrast images to identify uncomplicated cystic renal lesions: photon-counting detector CT vs. dual-energy integrating detector CT
Authors: Rau Stephan , Rau Alexander , Stein Thomas , Hagar Muhammad Taha , Faby Sebastian , Bamberg Fabian , Weiss Jakob
Published: March 2024

Purpose

To investigate the value of photon-counting detector CT (PCD-CT) derived virtual non-contrast (VNC) reconstructions to identify renal cysts in comparison with conventional dual-energy integrating detector (DE EID) CT-derived VNC reconstructions.

Material and methods

We prospectively enrolled consecutive patients with simple renal cysts (Bosniak classification—Version 2019, density ≤ 20 HU and/or enhancement ≤ 20 HU) who underwent multiphase (non-contrast, arterial, portal venous phase) PCD-CT and for whom non-contrast and portal venous phase DE EID-CT was available. Subsequently, VNC reconstructions were calculated for all contrast phases and density as well as contrast enhancement within the cysts were measured and compared. MRI and/or ultrasound served as reference standards for lesion classification.

Results

19 patients (1 cyst per patient; age 69.5 ± 10.7 years; 17 [89.5%] male) were included. Density measurements on PCD-CT non-contrast and VNC reconstructions (arterial and portal venous phase) revealed no significant effect on HU values (p = 0.301). In contrast, a significant difference between non-contrast vs. VNC images was found for DE EID-CT (p = 0.02). For PCD-CT, enhancement for VNC reconstructions was < 20 HU for all evaluated cysts. DE EID-CT measurements revealed an enhancement of > 20 HU in five lesions (26.3%) using the VNC reconstructions, which was not seen with the non-contrast images.

Conclusion

PCD-CT-derived VNC images allow for reliable and accurate characterization of simple cystic renal lesions similar to non-contrast scans whereas VNC images calculated from DE EID-CT resulted in substantial false characterization. Thus, PCD-CT-derived VNC images may substitute for non-contrast images and reduce radiation dose and follow-up imaging.
Hug sign in intraprocedural cone-beam-CT to predict short-term response to combined treatment of hepatocellular carcinoma
Authors: Iezzi Roberto , Posa Alessandro , Valente Iacopo , Contegiacomo Andrea , Zocco Maria Assunta , Pompili Maurizio , Annicchiarico Brigida Eleonora , Ponziani Francesca Romana , Basso Michele , Goldberg Shraga Nahum , Giuliante Felice , Gasbarrini Antonio , Sala Evis ,   HepatoCatt Study Group, Genco Enza , Brizi Gabriella , Cellini Francesco , Riccardi Laura , De Matthaeis Nicoletta , Biolato Marco , Miele Luca , Cerrito Lucia , Pizzolante Fabrizio , Grieco Antonio , Rapaccini Gian Ludovico , Marrone Giuseppe , Garcovich Matteo , Avolio Alfonso Wolfango , Ardito Francesco , Spoletini Gabriele , Agnes Salvatore , Vellone Maria
Published: March 2024

Objectives

Combined treatment of ablation and chemoembolization for hepatocellular carcinoma represents a promising therapy to increase treatment efficacy and improve patient survival. The “hug sign” is a recently introduced radiological sign consisting in deposition of beads/contrast agent during transarterial chemoembolization in the hyperemic area surrounding the post-ablation volume, seen during intraprocedural unenhanced cone-beam CT, that may indicate intraprocedural success. Aim of our retrospective study was to analyze the usefulness of the “hug sign” at the intraprocedural unenhanced cone-beam CT as an early predictor of response to combined treatment, based on the hug sign angle.

Materials and methods

Between January 2017 and September 2021 all patients with hepatocellular carcinoma which underwent a combined treatment of thermal ablation followed by chemoembolization were enrolled. All treated patients underwent immediate post-procedural unenhanced cone-beam CT to evaluate the deposition of contrast agent, lipiodol or radiopaque beads and to assess the percentage of coverage of the ablated area with the contrast agent (hug sign angle). Patients with missing pre-procedural, intra-procedural and/or post-procedural data/imaging, or with poor-quality post-procedural cone-beam CT images were excluded.

Results

128 patients (mean age, 69.3 years ± 1.1 [standard deviation]; 87 men) were evaluated. Our study evidenced that 84.4% (81/85) of patients with a hug sign angle of 360° had no residual tumor at the first 1-/3-months follow-up examination. A hug sign angle of 360° also showed to be an independent protective factor against residual tumor at multivariate analysis.

Conclusion

Unenhanced cone-beam CT performed at the end of a combined treatment with ablation plus chemoembolization can effectively predict an early treatment response on radiological images, when a hug sign angle of 360° was detected.
Long-term outcome of 9G MRI-guided vacuum-assisted breast biopsy: results of 293 single-center procedures and underestimation rate of high-risk lesions over 12 years
Authors: Rescinito Giuseppe , Brunetti Nicole , Garlaschi Alessandro , Tosto Simona , Gristina Licia , Conti Benedetta , Pieroni Diletta , Calabrese Massimo , Tagliafico Alberto Stefano
Published: March 2024

Purpose

Breast magnetic resonance imaging (MRI) can detect some malignant lesions that are not visible on mammography (MX) or ultrasound (US). If a targeted, second-look fails, MRI-guided breast biopsy is the only available tool to obtain a tissue sample and pathological proof of these “MRI-only lesions”. The aim of this study is to report the performance and underestimation rate of 9G MRI-guided vacuum-assisted breast biopsy (VABB) over 12 years at a single center.

Material and methods

All 9G MRI-VABB procedures performed from January 2010 to December 2021 were retrospectively reviewed. Two MRI scanners (1.5 T and 3 T) were used with the same image resolution and contrast media. All suspicious lesions detected only by breast MRI underwent biopsy. Reference standard was histological diagnosis or at least 1-year negative follow-up. All malignant and atypical lesions underwent surgery, which was used as the reference standard.

Results

A total of 293 biopsies were retrospectively reviewed. Histopathological VABB results revealed 142/293 (48.4%) benign lesions, 77/293 (26.2%) high-risk lesions, and 74/293 (25.2%) malignant lesions. No significant complications were observed. Surgical pathology results allowed for the reclassification of n = 7/48 B3b lesions: n = 4 were ductal carcinoma in situ, while n = 3 presented invasive features at surgical histology (2 IDC; 1 ILC). B3b underestimation occurred overall in 14.6% of B3 cases. Breast follow-up was achieved for all benign VABB results, and only one false-negative case was observed.

Conclusion

Our results confirm that 1.5 T and 3 T MRI-guided VABB is an accurate and safe procedure for histopathologic final diagnosis of MRI-only lesions. Critical issues remain the potential high-risk underestimation rate of B3b VABB results and management of follow-up of benign lesions.
Quantum Technologies: a Hermeneutic Technology Assessment Approach
Authors: Possati Luca M.
Published: March 2024

This paper develops a hermeneutic technology assessment of quantum technologies. It offers a “vision assessment” of quantum technologies that can eventually lead to socio-ethical analysis. Section 2 describes this methodological approach and in particular the concept of the hermeneutic circle applied to technology. Section 3 gives a generic overview of quantum technologies and their impacts. Sections 4 and 5 apply the hermeneutic technology assessment approach to the study of quantum technologies. Section 5 proposes distinguishing three levels in the analysis of the creation and communication of social meanings to quantum technologies: (a) fictions, (b) popularization, and (c) scientific journalism. Section 6 analyzes the results and defines some lines of action to increase social acceptance and trust in quantum technologies. The aim of this paper is to contribute to the debate on quantum technologies by enhancing the reflection on them and their potential, as well as illustrating the complexity of technological innovation and the need to shape it.
Capital risk, fiscal policy, and the distribution of wealth
Authors: Modena Andrea , Regis Luca
Published: March 2024

We develop a dynamic model economy where self-employed entrepreneurs allocate their net worth to their firm capital and risk-less government bonds, facing borrowing constraints, uninsurable labour endowment and capital depreciation risk. We derive a numerical approximation of the model’s equilibrium and compare it with a benchmark economy with no capital risk. Unlike labour endowment risk, capital risk reduces aggregate capital accumulation and wages and generates a positive risk premium. Low- (high-) net-worth entrepreneurs, whose consumption depends primarily on labour (financial) income, hold higher (lower) capital risk exposure. These patterns exacerbate inequality by increasing the share of financially constrained individuals and fattening the tails of the net worth distribution. Fiscal policy affects these outcomes by redistributing resources and affecting the risk premium. Capital tax cuts benefit more low- or high-net-worth entrepreneurs, depending on whether taxes on bonds or labour income finance them.
Bioactive compounds of fresh tea shoots plucked in different seasons: optimization of extraction of polyphenols
Authors: Chebbi Hind , Turkmen Erol Nihal , Incedayi Bige , Sari Ferda
Published: March 2024

In this study, the effects of harvest year and period on the total polyphenol (TP), radical scavenging activity (RSA), total flavonoid (TF) and ascorbic acid (AA) contents of fresh tea leaves were investigated. Extraction of polyphenols from the tea leaf was optimized using the response surface methodology (RSM). The effect of the independent variables ((solvent concentration, extraction time and solid to solvent (S/S) ratio)) on TP and RSA was studied using Box-Behnken design (BBD). The results showed that extraction parameters selected were significant in the extraction procedure regarding TP and RSA (p < 0.05). The optimum extraction conditions were obtained as 1/60.86 of S/S ratio, 84.65% of ethanol concentration and the extraction time of 50 min. As a result of the extraction of tea leaves under optimum conditions, the TP, RSA and TF contents of the leaves harvested in September in 2020 were found to be higher. In addition, the individual phenolic compounds of these leaves were analyzed by high performance liquid chromatography (HPLC) and epigallocatechin gallate (EGCG) was detected the most (57.52 mg/g DM). After in-vitro digestion of the same samples, TP and RSA values ​​were significantly decreased, mostly at intestinal stage (p < 0.05), and the bioaccessibility of the polyphenols was determined as 48.98%. As a result of AA analysis by HPLC of the, the highest contents for 2019 and 2020 were observed in the leaves harvested in May (41.92 mg/100 g DM) and those in July (38.55 mg/100 g DM), respectively.
Is There a Mitochondrial Protection via Remote Ischemic Conditioning in Settings of Anticancer Therapy Cardiotoxicity?
Authors: Kleinbongard Petra , Andreadou Ioanna
Published: March 2024

Purpose of Review

To provide an overview of (a) protective effects on mitochondria induced by remote ischemic conditioning (RIC) and (b) mitochondrial damage caused by anticancer therapy. We then discuss the available results of studies on mitochondrial protection via RIC in anticancer therapy-induced cardiotoxicity.

Recent Findings

In three experimental studies in healthy mice and pigs, there was a RIC-mediated protection against anthracycline-induced cardiotoxicity and there was some evidence of improved mitochondrial function with RIC. The RIC-mediated protection was not confirmed in the two available studies in cancer patients. In adult cancer patients, RIC was associated with an adverse outcome. There are no data on mitochondrial function in cancer patients.

Studies in tumor-bearing animals are needed to determine whether RIC does not interfere with the anticancer properties of the drugs and whether RIC actually improves mitochondrial function, ultimately resulting in improved cardiac function.
Comparison of consistency in centiloid scale among different analytical methods in amyloid PET: the CapAIBL, VIZCalc, and Amyquant methods
Authors: Shang Cong , Sakurai Keita , Nihashi Takashi , Arahata Yutaka , Takeda Akinori , Ishii Kazunari , Ishii Kenji , Matsuda Hiroshi , Ito Kengo , Kato Takashi , Toyama Hiroshi , Nakamura Akinori ,   BATON Study Group
Published: March 2024

Objective

The Centiloid (CL) scale is a standardized measure for quantifying amyloid deposition in amyloid positron emission tomography (PET) imaging. We aimed to assess the agreement among 3 CL calculation methods: CapAIBL, VIZCalc, and Amyquant.

Methods

This study included 192 participants (mean age: 71.5 years, range: 50–87 years), comprising 55 with Alzheimer’s disease, 65 with mild cognitive impairment, 13 with non-Alzheimer's dementia, and 59 cognitively normal participants. All the participants were assessed using the three CL calculation methods. Spearman’s rank correlation, linear regression, Friedman tests, Wilcoxon signed-rank tests, and Bland–Altman analysis were employed to assess data correlations, linear associations, method differences, and systematic bias, respectively.

Results

Strong correlations (rho = 0.99, p < .001) were observed among the CL values calculated using the three methods. Scatter plots and regression lines visually confirmed these strong correlations and met the validation criteria. Despite the robust correlations, a significant difference in CL value between CapAIBL and Amyquant was observed (36.1 ± 39.7 vs. 34.9 ± 39.4; p < .001). In contrast, no significant differences were found between CapAIBL and VIZCalc or between VIZCalc and Amyquant. The Bland–Altman analysis showed no observable systematic bias between the methods.

Conclusions

The study demonstrated strong agreement among the three methods for calculating CL values. Despite minor variations in the absolute values of the Centiloid scores obtained using these methods, the overall agreement suggests that they are interchangeable.
Game-theoretic analysis of competition between access service providers utilizing a Nash genetic algorithm
Authors: Kamalakis Thomas , Dede Georgia , Michalakelis Christos , Nikolaidou Mara
Published: March 2024

Fiber-to-the-home (FTTH) technology is a promising solution for providing advanced service delivery to end-users, but its implementation requires substantial capital expenditures. To minimize investment risks and aid decision-making for access service providers, we propose a game theoretic framework based on a modified Nash genetic algorithm. We illustrate how this framework can be applied to analyze the competition between access providers offering a flat-rate FTTH service on multiple geographical areas. Each provider determines its price for all areas simultaneously and decides whether to invest on a particular area depending on the anticipated revenues. Two distinct demand models are adopted to describe different types of consumer behavior. A solution engine, based on a modified mixed-variable Nash genetic algorithm is implemented under an open-source license. The significance and practical implications of the equilibrium points obtained for both single and multiple area games are discussed. The proposed framework and the solution engine developed, aid both providers and regulatory bodies to analyze competitive environments. They can also be used to implement decision support tools for similar problems as well. The paper concludes by pointing out further research directions in this context.
Multianalytical approach to the exceptional Late Roman shipwreck of Ses Fontanelles (Mallorca, Balearic Islands, Spain)
Authors: Cau-Ontiveros Miguel Ángel , Bernal-Casasola Darío , Pecci Alessandra , Fantuzzi Leandro , Picornell-Gelabert Llorenç , Valenzuela Oliver Alejandro , Retamosa José Alberto , Portillo-Sotelo José Luis , Cardell Perelló Jaume , Munar Llabrés Sebastià , de Juan Fuertes Carlos , García Riaza Enrique
Published: March 2024

The paper presents the results of an interim analytical approach to the Late Roman shipwreck of Ses Fontanelles recently found in the island of Mallorca (Balearic Islands, Spain). The excellent state of preservation of the hull and the cargo, including amphorae with painted inscriptions (tituli picti), and its location in shallow waters offshore of one of the main touristic beaches of the island makes this a unique finding in the Mediterranean. A first season of excavations and study of the cargo triggered an analytical approach to solve some of the problems pose by archaeological research, mainly related to the possible origin of the vessel. The analytical strategy combines petrographic analysis for the study of the provenance of the amphorae, archaeozoology and residue analysis to identify their content, and analysis of the wood and plant remains to understand the use of vegetal resources in shipbuilding and in the stow of the cargo. The results of the combination of the petrographic analysis, the study of the ichthyofauna and the organic residue analysis suggest that the boat probably departed from the area of Cartagena in the southeastern part of the Iberian Peninsula, carrying a cargo of fish sauce (liquaminis flos), oil, and wine (probably also some olives preserved in grape derivatives), transported in three main types of amphorae. The analysis of the wood shows, as known in Roman shipbuilding, a clear selection of forest resources. The shipbuilders used pine for longitudinal parts of the hull, while for the small pieces related to the assemblage system (pegged, mortise and tenons) and subjected to a great stress they selected harder woods mainly Cupressaceae, Olea europaea, and Laurus nobilis. In addition, the study reveals that mainly branches of Vitis vinifera, but also other herbaceous plants were used as dunnage protecting the cargo during the journey. The results help to shed some light into different aspects of this unique vessel sunk in Mallorcan waters and contributes to show the benefit of applying archaeological sciences in maritime archaeology.