bluuebunny/crossref_metadata_2025 huggingface dataset:
Citizenship Education in the K to 12 Junior High School Economics Curriculum in the Philippines: A Content Analysis
Authors: Dizon Arnie G.
Published: March 2022

This study describes the integration of citizenship education into the K to 12 Junior High School Economics curriculum in the Philippines. Content analysis of the 2016 Curriculum Guide Learning Competencies (CGLCs) and 2020 Most Essential Learning Competencies (MELCs) for Social Studies was conducted to determine the alignment of the Economics curriculum with liberal individualist and civic republican conceptions of citizenship. Gaps that need to be addressed in the alignment of Economics learning competencies with citizenship education were explicated. Results of the study show that the Junior High School Economics curriculum integrates liberal individualist and civic republican conceptions of citizenship. However, civic-oriented outcomes like wastong pagbabayad ng buwis (correct payment of taxes) and bayanihan spirit (communal unity) need to be explicitly stated to ensure that these essential outcomes will not be missed out in the unpacking of the learning competencies.
Action Beyond Exhibition: Amplifying Photovoice Through Social Action After a Community Health Needs Assessment in Philadelphia
Authors: Dafilou Caleb , Arisi Maria F. , Pepe Vincent , Hehir Martin , McKeegan John , Rinier Felicia , Brawer Rickie
Published: March 2022

Photovoice is a participatory action research method that was founded on mobilizing communities toward action. However, there is limited research detailing the action stages of photovoice that are meant to follow the initial research. In this article, we describe the action stage of a youth photovoice project conducted at the planning phase of a Community Health Needs Assessment of the Latino community in North Philadelphia. In collaboration with local leaders, we utilized photovoice to prioritize the health needs identified in the assessment. We announced a request for proposals and launched twelve, 1-year, community catalyst grants in the amount of US$50,000 each. While grants were funded and implemented, the participants continued to exhibit their findings in Philadelphia City Hall and engage with city policymakers. We developed a health policy workshop where Philadelphia youth beyond the original photovoice participants could learn advocacy skills and policy research to develop a proposal addressing a priority health need identified through photovoice. This workshop was expanded into a year-round program where participants can be matched with a career mentor, engage in professional development sessions, and continue to refine and advocate for their policy proposal. We found that successful action planning stemmed from setting goals several steps ahead of the current stage of action while enhancing the ability to center community voice in guiding action forward. Photovoice influenced decision-making throughout each of the steps taken toward action. Future research should recognize and describe action planning as a central tenet of photovoice methodologies.
Revisiting the Roots and Aims of Photovoice
Authors: Strack Robert W. , Orsini Muhsin Michael , Ewald D. Rose
Published: March 2022

Since its introduction, photovoice has been implemented in numerous fields with a wide array of outcomes of interest, but has the method been implemented in a way that is consistent with its initial aims in mind? From Caroline Wang and Mary Ann Burris’s initial 1994 project, photovoice has demonstrated power to harness visual imagery and stories within a participatory empowerment process and established a new tool for the profession for understanding community members’ lived experience and needs, raising the critical consciousness of communities, and advocating for actions leading to social change. Based in Freirean philosophy, feminist theory, and documentary photography, photovoice engages community members to identify, represent, and change their community by means of photography, dialogue, and action. Public health can benefit when researchers and practitioners more carefully conceptualize the intended aims of each photovoice effort. The purpose of this article is to consider the varied applications of photovoice and propose a classification system that encapsulates its wide-ranging aims. Close examination of foundational literature and previous applications of photovoice suggest the following categories for framing the application of the method; specifically, photovoice for (a) photovention, (b) community assessment, (c) community capacity building, and (d) advocacy for change. Full implementations of photovoice have the capacity to illuminate complex real-world issues leading to advocacy for policy, systems, and environmental change. It is our hope that the proposed framing clarifies the language used to discuss photovoice and its outcomes, distinguishes its various uses and stated aims, and maximizes its impact in future applications.
Bilingualism and the Televisual Architecture of Linguistic (dis-) Encounters in the Israeli Television Show Arab Labor
Authors: Ribke Nahuel
Published: March 2022

Considered the first fully Hebrew-Arabic bilingual television show on Israeli prime time television, Arab Labor (2007–2013) attracted the attention of critics and scholars for its sharp satire and criticism of the daily dilemmas and discrimination faced by Israeli Arab citizens. Although its success among audiences and critics opened the door for other bilingual television shows spoken in Hebrew and Arabic, it also caused frustration for the series’ creator due the limits imposed by commercial television operating in an antagonistic socio-political context. While previous studies on the show have focused on its main narrative conflicts and themes, the present study proposes to examine the televisual spatio-temporal, linguistic and dramatic structures that foster the encounters and conflicts between the two languages spoken in the series.
Intravenous Lidocaine Infusion Reduce Post-operative Pain and Length of Hospital in Elderly Patients Undergoing Surgery: Meta-analysis of Randomized Controlled Trials
Authors: Zhu Yihao , Wang Fei , Yang Lei , Zhu Tao
Published: March 2022

Objective. It is debated wheter intravenous (IV) lidocaine improves post-operative pain and has other potential benefits in elderly patients. This systematic review and meta-analysis aimed to estimate the effect of perioperative continuous IV lidocaine in elderly patients undergoing surgery. Method. PubMed/Medline, Web of Science, Embase, and CENTRAL databases (through OVID SP) were searched independently until October 10, 2020 by two authors. We included all randomized controlled trials that compared the effect of continuous IV lidocaine and any placebo or no treatment in elderly patients after surgery. Primary outcomes were length of hospital stay and post-operative pain score. Results. Eighteen studies (988 patients) were included. Meta-analysis suggested that IV lidocaine reduced the post-operative pain scores 2 hours (standardized mean difference [SMD]: −1.58, 95% confidence interval [CI]: −2.03 to −1.13), 4 hours (SMD:−1.20, 95% CI: −2.02 to −.39), 8 hours (SMD:−.82, 95% CI: −1.51 to −.13), 12 hours (SMD:−.66, 95% CI: −1.28 to −.04), and 24 hours (SMD:−.42, 95% CI: −.72 to −.12) post-operatively. Moreover, those patients given IV lidocaine had a shorter length of hospital stay (MD: −.24, 95% CI: −.71 to −.23) and required fewer opioid drugs (SMD: −.31, 95% CI: −.31 to −.01). Conclusion. The evidence suggested that IV lidocaine significantly reduced post-operative pain intensity and opioid consumption and shortened the length of hospital stay in elderly patients. IV lidocaine decreased the incidence of post-operative nausea while it could not reduce the incidence of post-operative vomiting and accelerate the recovery of gastrointestinal function.
Proximal balloon-guided catheter with flow inversion vs. distal filter protection during the carotid stent placement, a seven years experience in a Colombian reference center
Authors: Garcia-Ledesma O , Mantilla D , Correa-Ruiz PA , D Vera D , Valenzuela-Santos C , Serrano-Gómez S , Reyes A , Galvis M , Ferreira-Prada CA , Vargas O
Published: March 2022

Background and purpose

The carotid stent placement as a therapeutic option for carotid stenosis has been increasing among years; therefore, studies are required to evaluate the security and efficacy of its materials. The purpose of this study was to evaluate the distal filter and the proximal balloon-guided catheter with flow inversion as protection devices during carotid angioplasty and stenting.

Methods

This is a retrospective, observational study of patients diagnosed with carotid stenosis treated with angioplasty between January 1, 2014, and June 30, 2020; we analyzed a radiology service database to compare the distal filter and the proximal balloon-guided catheter as protection devices during angioplasty.

Results

One hundred seventy-five angioplasties were performed, the distal filter was the most prevalent embolic protection device used (66%), patients baseline characteristics did not differ between groups with different embolic protection devices, except for history of dyslipidemia ( p  <  0.000). As well, we did not find any significant differences between the groups in the device related complications, intervention time ( p  =  0.140), unrelated complications ( p  =  0.693) and functional independence at 90 days (p =  0.096).

Conclusions

In our study the proximal balloon-guided catheter and the distal filter protection device as protection devices during the carotid stenting didn't show significant differences regarding complications related to the system.
Intelligent data expansion approach of vibration gray texture images of rolling bearing based on improved WGAN-GP
Authors: Fan Hongwei , Ma Jiateng , Zhang Xuhui , Xue Ceyi , Yan Yang , Ma Ningge
Published: March 2022

Rolling bearing is one of the components with the high fault rate for rotating machinery. Big data-based deep learning is a hot topic in the field of bearing fault diagnosis. However, it is difficult to obtain the big actual data, which leads to a low accuracy of bearing fault diagnosis. WGAN-based data expansion approach is discussed in this paper. Firstly, the vibration signal is converted into the gray texture image by LBP to build the original data set. The small original data set is used to generate the new big data set by WGAN with GP. In order to verify its effectiveness, MMD is used for the expansion evaluation, and then the effect of the newly generated data on the original data expansion in different proportions is verified by CNN. The test results show that WGAN-GP data expansion approach can generate the high-quality samples, and CNN-based classification accuracy increases from 92.5% to 97.5% before and after the data expansion.
True aneurysm of the dorsalis pedis artery
Authors: Mahmoud Amr A
Published: March 2022

Objectives

Aneurysm of the pedal arteries is uncommon. I present a case of non-traumatic fusiform true aneurysm of the dorsalis pedis artery in an otherwise well 45-year-old man. Color flow duplex imaging revealed aneurysmal dilation, involving all layers of the artery wall, measuring 16.5 * 10 mm with irregular intraluminal thrombus across a 6.33-mm segment. Due to concerns over embolization, our patient underwent successful ligation of the dorsalis pedis artery. He had an uneventful post-operative recovery.

Methods

Case report

Results

No postoperative complication or signs of ischemia

Conclusions

Treatment of asymptomatic dorsalis pedis artery aneurysm may be of value to prevent risk of thrombo-embolic complications, foot ischemia, or rupture without warning signs. Patency of the pedal arch is important to avoid foot ischemia in case of dorsalis pedis artery ligation.
Cardiovascular effects of hyoscine butylbromide in patients under general anaesthesia
Authors: Quintero Carlos , Molano Maria F , Amaya Sebastian , Maya Jose J , Andrade María J
Published: March 2022

Background:

Cardiovascular effects for drugs such as hyoscine butylbromide are poorly documented in the literature, unlike atropine, which is considered the antimuscarinic of choice in the presence of intraoperative bradycardia.

Aim:

The aim of the study was to describe the dose-related cardiovascular effect of hyoscine butylbromide in patients between 18 and 65 years of age, with low perioperative risk undergoing elective surgery under general anaesthesia on an outpatient basis or hospitalised at our institution between 1 January and 31 May 2019.

Methods:

Descriptive, cross-sectional, retrospective study; 28 patients with low perioperative risk who underwent general anaesthesia were selected. Changes in heart rate and blood pressure were analysed during the first 6 minutes after the administration of hyoscine butylbromide. The data obtained was recorded in a Microsoft Excel database and analysed using the Excel analysis tool and IBM SPSS.

Results:

The average dose of 0.15mg/kg of hyoscine butylbromide achieved an increase in heart rate and mean arterial pressure in 96% and 92.8%, respectively, in the first 6 minutes after the administration. Significant changes in heart rate and blood pressure were obtained during the first 6 minutes at doses between 0.05mg/kg and 0.15mg/kg.

Conclusion:

Hyoscine butylbromide generates positive effects on the heart rate and blood pressure of patients under general anaesthesia, representing a possible alternative in the management of intraoperative bradycardia.
The World-Directedness of Emotional Feeling: Affective Intentionality and Position-Taking
Authors: Müller Jean Moritz
Published: March 2022

This article is a précis of my 2019 monograph The World-Directedness of Emotional Feeling: On Affect and Intentionality. The book engages with a growing trend of philosophical thinking according to which the felt dimension and the intentionality of emotion are unified. While sympathetic to the general approach, I argue for a reconceptualization of the form of intentionality that emotional feelings are widely thought to possess and, accordingly, of the kind of role they play in our mental lives. More specifically, I argue that the way we feel in having an emotion is not a perception-like awareness of evaluative properties of its object, but instead constitutes the taking of a stand or position on this object in light of its evaluative properties.
α-Glucosidase Inhibitory Activity and Quantitative Contribution of Phenolic Compounds From Vietnamese Aquilaria crassna Leaves
Authors: Nguyen Thi Ngoc Tram , Le Thanh Duy , Nguyen Phuoc Long , Nguyen Duc Hanh , Nguyen Huynh Van Thi , Nguyen Tan Khanh , Tran Manh Hung , Le Thi Hong Van
Published: March 2022

Aquilaria crassna Pierre ex Lecomte, Thymelaeaceae, is cultivated for producing resinous heartwood, also called agarwood. Its leaves are a source of herbal tea in Vietnam due to its rich content of polyphenols. However, the α-glucosidase inhibition activity and the contents of phenolic compounds in leaves of different ages have not yet been determined. In the current study, 7 polyphenols [iriflophenone 3,5-C- β-D-diglucoside (1), iriflophenone 3-C- β-D-glucoside (2), mangiferin (3), iriflophenone 2- O- α-rhamnoside (4), genkwanin 5- O- β-primeveroside (5), genkwanin 4′-methyl ether 5- O- β-primeveroside (6), and genkwanin (7)] were isolated from the leaves of A crassna. Among them, genkwanin (7), an O-methylated flavone, was the most active compound that inhibited α-glucosidase activity, with an IC50 value of 24.0 μM. Molecular docking studies were performed to understand the binding interactions of the active compounds. In addition, a reliable and straightforward reversed-phase HPLC method was developed to determine the content of compounds in different leaves of A crassna. Mangiferin (3) showed the highest content. The contents of 1-4 contributed to the total polyphenolic contents and significantly decreased from the youngest to the oldest leaf. The contents of 5-7 fluctuated through various ages of leaves. Compounds 5 and 6 showed a low accumulation in the first and second leaves, then obtained high contents among middle leaves and declined in the oldest. These results suggested that A crassna and its polyphenols may prevent the development and progression of diabetes through α-glucosidase inhibition. Also, the analysis of the polyphenol content in A crassna may be helpful for tea product manufacture.
Improving online clinical sexual and reproductive health information to support self-care: A realist review
Authors: Courtenay Thomas , Baraitser Paula
Published: March 2022

Self-care is the ability of individuals, families and communities to promote health, prevent disease, maintain health, and cope with illness and disability with or without the support of a healthcare provider. In the field of sexual and reproductive health options for self-care predominantly include ordering contraceptives online, or testing and treating genital infections outside a healthcare setting. The shift to digitally facilitated self-care consequently requires information that was previously used by clinicians to be made available to those managing their own sexual and reproductive health. This review was specifically interested in how to optimise this informational enabling environment as self-care becomes more complex. Using a realist approach to facilitate collation, analysis and synthesis of research from multiple disciplines this review sought to enable the generation of a programme theory to inform service development. The majority of research we identified studied information to support the choice to self-care and access to self-care. In contrast to established areas of self-care, for example, the management of diabetes or hypertension, studies of the self-care process in sexual and reproductive health are lacking. There is significant potential to expand digital information resources to support sexual and reproductive health self-care, however, there are currently significant unmet informational needs. This review proposes six key recommendations for providers and key stakeholders involved with sexual and reproductive healthcare for the improvement of digital self-care services.
Performance After Concussion in National Basketball Association Players
Authors: DeFroda Steven F. , Patel Devan D. , Milner John D. , Yang Daniel S. , Owens Brett D.
Published: March 2022

Background:

Concussions have received national attention in collision sports such as football, soccer, and hockey, but less focus has been placed on basketball.

Purpose:

To determine return-to-play (RTP) and player performance in the first and second season after concussion in National Basketball Association (NBA) players.

Study Design:

Descriptive epidemiology study.

Methods:

An online database of publicly available NBA athlete injuries was queried for instances of “concussion” between 2010 and 2018. The age at injury, team, position, height, weight, body mass index, NBA experience, date of concussion, date of return, and seasons played postconcussion was recorded for each player. Regular-season statistics (games started, games played, minutes played, and player efficiency rating [PER]) were compiled for the season before, and 2 seasons immediately after, injury. Kaplan-Meier survivorship plots were computed for athlete RTP and retirement endpoints.

Results:

A total of 81 injuries were identified from 2010 to 2018, with a rate of 2.0 concussions per 100 player-years. Overall RTP was 100% after concussion, with nearly all (88%) returning in the season of injury; 12% of players experienced a season-ending concussion. RTP averaged 37.3 days after injury, varying widely (range, 2-291 days). Compared with preinjury season (78.0%), athletes played in significantly fewer overall games in the season of injury (36.6%; P < .0001), as well as 1 (69.5%; P = .0229) and 2 seasons postinjury (73.2%; P = .3192). PER scores were not significantly different across the study period. Each point increase in a player’s preinjury PER score was associated with a 2.4% decrease in PER from the preinjury season to season of injury ( P = .0016) and a 3.1% decrease from preinjury to season after injury ( P = .0053). Each increasing year of age or year of experience was associated with 5% decline in PER score at 1 season after injury.

Conclusion:

NBA players had a high RTP after concussion, with most returning in the same season as the injury. Players sustaining concussions played significantly fewer games for at least 2 seasons after injury. Performance via PER did not change across the entire cohort; however, players with higher preinjury PER, and older players were more likely to sustain a greater decline in performance after injury.
Post-Discharge Transitional Care Program and Patient Compliance With Follow-Up Activities
Authors: Bhandari Neeraj , Epane Josue , Reeves Jerry , Cochran Christopher , Shen Jay
Published: March 2022

We explore whether the frequency of post-hospital discharge transitional care calls affects patients’ adherence to their discharge plans. We reviewed 1,000 call records of a post-discharge transitional care program run by a large U.S. tertiary care hospital in 2018–2019 and generated binary outcomes capturing patient self-reports of (1) scheduling or completing follow-up appointments, procedures, or prescription fills, (2) missing a scheduled event, and (3) reporting a new adverse clinical event. Our predictor variables captured callers’ success in completing the first and each subsequent call with discharged patients. We ran linear probability models (LPM) for each binary outcome after controlling for sociodemographic and clinical characteristics. Results indicate successful completion of the first two calls was associated with the increased probability of scheduling or completing follow-up appointment (15.5% points, p < 0.01) and follow-up procedure (13.5% points, p < 0.01), and reporting new adverse event (5.9% points, p < 0.05). Our findings suggest that making the first phone call to patients, while crucial, may not be sufficient for effective care transition; making two to three phone calls seems to be more optimal, while further calls may have limited value.
Social Inequalities and Health among Older Immigrant Women in the Nordic Countries: An Integrative Review
Authors: Debesay Jonas , Nortvedt Line , Langhammer Birgitta
Published: March 2022

Introduction

The Nordic countries have a surprisingly strong relative socioeconomic health inequality. Immigrants seem to be disproportionately affected due to their social economic position in the host countries. Healthcare professionals, including nurses, have a professional obligation to adhere to fairness and social equity in healthcare. The aim of this review was to identify and synthesize research on health status and the impact of social inequalities in older immigrant women in the Nordic countries.

Methods

We conducted an integrative review guided by the Whittemore and Knafl integrative review method. We searched multiple research databases using the keywords immigrant, older, women, socioeconomic inequality, health inequality, and Nordic countries. The results were limited to research published between 1990 and 2021. The retrieved articles were screened and assessed by two independent reviewers.

Results

Based on the few studies on older immigrant women in the Nordic countries, the review findings indicate that they fare worse in many health indicators compared to immigrant men and the majority population. These differences are related to various health issues, such as anxiety, depression, diabetes, multimorbidity, sedentary lifestyle, and quality of life. Lower participation in cancer screening programs is also a distinctive feature among immigrant women, which could be related to the immigrant women's help-seeking behavior. Transnational family obligations and responsibilities locally leave little room for prioritizing self-care, but differing views of health conditions might also contribute to avoidance of healthcare services.

Conclusion

This integrative review shows that there is a paucity of studies on the impact of social inequalities on the health status of older immigrant women in the Nordic countries. There is a need for not only research focused on the experiences of health status and inequality but also larger studies mapping the connection between older immigrant women's economic and health status and access to healthcare services.
Dependency and Hardship in the Gig Economy: The Mental Health Consequences of Platform Work
Authors: Glavin Paul , Schieman Scott
Published: March 2022

The authors investigate the relationship between platform work engagement and worker mental health on the basis of two nationally representative samples of Canadian workers. Integrating insights from the job demands–resources model and Schor’s idea of “platform dependence,” the authors examine whether a dependent attachment to the platform economy is associated with poorer mental health. Multivariate analyses reveal that dependent platform workers report higher levels of psychological distress than secondary platform workers, wage workers, and the traditional self-employed. In contrast to work conditions, which contribute little to these distress patterns, financial strain explains approximately 50 percent of dependent platform workers’ higher distress. Contingency analyses reveal that financial strain also exacerbates the mental health penalties associated with dependent platform work. These findings support a “dependent-precarity” perspective of platform work stress, raising questions about the future health challenges posed by platform work in a postpandemic economy.
Cellular-level in planta analysis of radial movement of minerals in a konara oak (Quercus serrata Murray) trunk
Authors: Kuroda Katsushi , Yamane Kenichi , Itoh Yuko
Published: March 2022

After the Fukushima Daiichi Nuclear Power Plant accident, radiocesium, one of the main radioactive materials, has been accumulated inside konara oak trunks. Radiocesium has been thought to move radially through the trunk, but it has not been scientifically vindicated because the mechanism of the radial movement of minerals has not yet been experimentally determined. In this study, mineral radial movement was investigated in konara oak trunks of standing trees. A stable isotope cesium (Cs) solution was injected as a tracer into the outer sapwood of standing konara oak tree trunks. A trunk part was subsequently freeze-fixed with liquid nitrogen and subjected to Cs distribution analysis using cryo-scanning electron microscopy/energy-dispersive X-ray spectroscopy. By comparing normal samples that included living cells and freeze–thaw treated samples that contained no living cells, it was concluded that the injected Cs has been moving through the sapwood by the combination of rapid symplasmic movement by virtue of the living xylem parenchyma cells and slow apoplastic diffusion. Conversely, the Cs solution did not diffuse from the sapwood to the heartwood, implying that Cs is exuded from the living parenchyma cells to the apoplast, i.e., cell walls or adjoined dead parenchyma cells in the layer at the sapwood–heartwood boundary, and then diffused into the heartwood. By integrating the results of this study and our previous results obtained on Japanese cedar, we conclude that the mechanism of the radial movement of minerals through the sapwood seems to be a universal characteristic of tree species. In contrast, since mineral concentrations varied among tree species, the movement mechanism across the sapwood–heartwood boundary can differ among tree species.
Migraine susceptibility is modulated by food triggers and analgesic overuse via sulfotransferase inhibition
Authors: Vuralli Doga , Arslan Burak , Topa Elif , de Morais Andreia Lopes , Gulbahar Ozlem , Ayata Cenk , Bolay Hayrunnisa
Published: March 2022

Background/aim

Certain constituents in migraine food triggers and non-steroidal anti-inflammatory drugs (NSAIDs) inhibit sulfotransferases (SULTs) that detoxify drugs/chemicals and play role in the metabolism of neurotransmitters. We aimed to dissect SULT1A1 modulation of CSD susceptibility and behavior in an in vivo experimental model using hesperidin, a SULT1A1 inhibitor found in citrus fruits (known migraine triggers) and mefenamic acid (SULT1A1 inhibitor), an NSAID to simulate medication overuse.

Methods

Hesperidin was used as SULT1A1 inhibitor found in citrus fruits, known migraine triggers and mefenamic acid (NSAID), another SULT1A1 inhibitor, was used to induce MO in rats. The groups were; 1) Hesperidin (ip) or its vehicle-DMSO (ip) 2) Chronic (4 weeks) mefenamic acid (ip) or its vehicle (ip) 3) Chronic mefenamic acid+hesperidin (ip) or DMSO (ip). CSD susceptibility was evaluated and behavioral testing was performed. SULT1A1 enzyme activity was measured in brain samples.

Results

Single-dose of hesperidin neither changed CSD susceptibility nor resulted in any behavioral change. Chronic mefenamic acid exposure resulted in increased CSD susceptibility, mechanical-thermal hypersensitivity, increased head shake, grooming and freezing and decreased locomotion. Single dose hesperidin administration after chronic mefenamic acid exposure resulted in increased CSD susceptibility and mechanical-thermal hypersensitivity, increased freezing and decreased locomotion. SULT1A1 enzyme activity was lower in mefenamic acid and mefenamic acid+hesperidin groups compared to their vehicles.

Conclusion

Mefenamic acid and hesperidin have synergistic effect in modulating CSD susceptibility and pain behavior. Sulfotransferase inhibition may be the common mechanism by which food triggers and NSAIDs modulate migraine susceptibility. Further investigations regarding human provocation studies using hesperidin in migraine patients with medication overuse are needed.
Simple method for cutoff point identification in descriptive high-throughput biological studies
Authors: Suvorov Alexander
Published: March 2022

Background

Rapid development of high-throughput omics technologies generates an increasing interest in algorithms for cutoff point identification. Existing cutoff methods and tools identify cutoff points based on an association of continuous variables with another variable, such as phenotype, disease state, or treatment group. These approaches are not applicable for descriptive studies in which continuous variables are reported without known association with any biologically meaningful variables.

Results

The most common shape of the ranked distribution of continuous variables in high-throughput descriptive studies corresponds to a biphasic curve, where the first phase includes a big number of variables with values slowly growing with rank and the second phase includes a smaller number of variables rapidly growing with rank. This study describes an easy algorithm to identify the boundary between these phases to be used as a cutoff point.

Discussion

The major assumption of that approach is that a small number of variables with high values dominate the biological system and determine its major processes and functions. This approach was tested on three different datasets: human genes and their expression values in the human cerebral cortex, mammalian genes and their values of sensitivity to chemical exposures, and human proteins and their expression values in the human heart. In every case, the described cutoff identification method produced shortlists of variables (genes, proteins) highly relevant for dominant functions/pathways of the analyzed biological systems.

Conclusions

The described method for cutoff identification may be used to prioritize variables in descriptive omics studies for a focused functional analysis, in situations where other methods of dichotomization of data are inaccessible.
Cold stress tolerance of the intertidal red alga Neoporphyra haitanensis
Authors: Zhu Shanshan , Gu Denghui , Lu Caiping , Zhang Caixia , Chen Juanjuan , Yang Rui , Luo Qijun , Wang Tiegan , Zhang Peng , Chen Haimin
Published: March 2022

Background

Red algae Porphyra sensu lato grow naturally in the unfavorable intertidal environment, in which they are exposed to substantial temperature fluctuations. The strategies of Porphyra to tolerate cold stress are poorly understood.

Results

Herein, investigations revealed that chilling and freezing induced alterations in the physiological properties, gene transcriptional profiles and metabolite levels in the economically important red algae species, Neoporphyra haitanensis. Control samples (kept at 20 °C) were compared to chilled thalli (10 and 4 °C) and to thalli under − 4 °C conditions. Chilling stress did not affect the health or photosynthetic efficiency of gametophytes, but freezing conditions resulted in the arrest of growth, death of some cells and a decrease in photosynthetic activity as calculated by Fv/Fm. Transcriptome sequencing analysis revealed that the photosynthetic system was down-regulated along with genes associated with carbon fixation and primary metabolic biosynthesis. Adaptive mechanisms included an increase in unsaturated fatty acids levels to improve membrane fluidity, an increase in floridoside and isofloridoside content to enhance osmotic resistance, and an elevation in levels of some resistance-associated phytohormones (abscisic acid, salicylic acid, and methyl jasmonic acid). These physiochemical alterations occurred together with the upregulation of ribosome biogenesis.

Conclusions

N. haitanensis adopts multiple protective mechanisms to maintain homeostasis of cellular physiology in tolerance to cold stress.
Non-vitamin K antagonist oral anticoagulants in venous thromboembolism patients: a meta-analysis of real-world studies
Authors: Liu Zhi-Yan , Zhang Han-Xu , Ma Ling-Yue , Mu Guang-Yan , Xie Qiu-Fen , Zhou Shuang , Wang Zi-Ning , Wang Zhe , Hu Kun , Xiang Qian , Cui Yi-Min
Published: March 2022

Background

The real-world studies on recurrent venous thromboembolism (VTE) and bleeding events of non-vitamin K antagonist oral anticoagulants (NOACs) in VTE patients have reported conflicting findings. Our study aimed to provide the direct comparison evidence of different NOACs for VTE patients in clinical practice settings.

Methods

Search of the medical literature was conducted using PubMed, Web of Science, EMBASE, Clinical Trials.gov, and the Cochrane Library from inception to March 22, 2021. Among the 19,996 citations retrieved, a total of 63,144 patients from 6 studies were analyzed. Clinical outcomes included recurrent VTE, death, and different bleeding events.

Results

Adjusted hazard ratio (HR) analysis suggested that apixaban had significant lower bleeding riskthan rivaroxaban (major, minor and any bleeding: HR = 0.61, 0.56, 0.70; p = 0.008, < 0.0001, 0.006, respectively), but no statistics difference found in recurrent VTE events (HR = 1.02, 95% confidence interval (CI) 0.71–1.47, p = 0.93). There was no significant difference of major bleeding between dabigatran and rivaroxaban (odds ratios (OR) = 0.41, 95% CI 0.09–1.90, p = 0.25), apixaban and dabigatran (OR 0.64, 95% CI 0.15–2.72, p = 0.83). No significant difference was found in the comparison of edoxaban and other NOACs in VTE recurrence, major bleeding and composite outcome.

Conclusions

In the prevention of bleeding events, apixaban was associated with a lower risk than rivaroxaban, but equivalent efficacy for different NOACs in prevention of recurrent VTE. Evidence generated from the meta-analysis based on real-world data can help to guide selection between apixaban and rivaroxaban in routine clinical practice.

Trial registration: This systematic review and meta-analysis were conducted and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis and Meta-analysis of Observational Studies in Epidemiology statements and was registered with PROSPERO (CRD42019140553).
Seeking medical services among rural empty-nest elderly in China: a qualitative study
Authors: Wu Yijin , Zhang Quan , Huang Yan , Qiu Sihang
Published: March 2022

Background

The number of empty-nest elderly in China is rapidly increasing. Empty-nest elderly could not receive adequate daily care, economic support and spiritual consolation from their children. Rural empty-nest elderly are facing more serious health challenges than those in urban areas.

Objective

This study aimed to understand the experiences of rural empty-nest elderly in seeking medical services in China.

Methods

The method of inductive content analysis was used to collect and analyze data. Data were collected by in-depth interviews. A total number of 16 participants were involved in this study. A semi-structured interview guideline, which was discussed in depth and agreed upon by all researchers, was used to encourage participants to talk about their experiences in seeking medical services.

Results

Rural empty-nest elderly is facing a great challenge in seeking medical services in China. There are some barriers for rural nest elderly to get access to healthcare services, such as low-income status, high expenditure of medical treatment and inadequate health insurance coverage. Due to the absence of the companionship of their adult children, empty-nest elderly have to rely on their neighbors and relatives to seek medical services.

Conclusions

Rural empty-nest elderly have great difficulty in seeking medical services in China. More efforts should be made to get medical services more accessible to rural empty-nest elderly.
External validation study on the value of deep learning algorithm for the prediction of hematoma expansion from noncontrast CT scans
Authors: Guo Dong Chuang , Gu Jun , He Jian , Chu Hai Rui , Dong Na , Zheng Yi Feng
Published: March 2022

Background

Hematoma expansion is an independent predictor of patient outcome and mortality. The early diagnosis of hematoma expansion is crucial for selecting clinical treatment options. This study aims to explore the value of a deep learning algorithm for the prediction of hematoma expansion from non-contrast computed tomography (NCCT) scan through external validation.

Methods

102 NCCT images of hypertensive intracerebral hemorrhage (HICH) patients diagnosed in our hospital were retrospectively reviewed. The initial computed tomography (CT) scan images were evaluated by a commercial Artificial Intelligence (AI) software using deep learning algorithm and radiologists respectively to predict hematoma expansion and the corresponding sensitivity, specificity and accuracy of the two groups were calculated and compared. Comparisons were also conducted among gold standard hematoma expansion diagnosis time, AI software diagnosis time and doctors’ reading time.

Results

Among 102 HICH patients, the sensitivity, specificity, and accuracy of hematoma expansion prediction in the AI group were higher than those in the doctor group(80.0% vs 66.7%, 73.6% vs 58.3%, 75.5% vs 60.8%), with statistically significant difference (p < 0.05). The AI diagnosis time (2.8 ± 0.3 s) and the doctors’ diagnosis time (11.7 ± 0.3 s) were both significantly shorter than the gold standard diagnosis time (14.5 ± 8.8 h) (p < 0.05), AI diagnosis time was significantly shorter than that of doctors (p < 0.05).

Conclusions

Deep learning algorithm could effectively predict hematoma expansion at an early stage from the initial CT scan images of HICH patients after onset with high sensitivity and specificity and greatly shortened diagnosis time, which provides a new, accurate, easy-to-use and fast method for the early prediction of hematoma expansion.
Knowledge and attitudes of adolescent girls and their mothers about early pregnancy: a cross-sectional study
Authors: Naghizadeh Somayyeh , Mirghafourvand Mojgan
Published: March 2022

Background

Adolescent pregnancy is an important public health problem and a socio-economic challenge in diverse societies. As a tremendously important problem, this issue has caused major concerns, as it exposes adolescent girls to social isolation and physical and psychological harm. So, this study aimed to determine the knowledge and attitude of adolescent girls and their mothers about early pregnancy, its causes, consequences, and predictors in Tabriz-Iran in 2020–21.

Methods

This cross-sectional study was done with 540 people (270 adolescent girls and 270 mothers) in the health centers of Tabriz. Data were collected using the questionnaires of sociodemographic information, knowledge, and adolescent girls’ attitudes and their mothers about early pregnancy, its causes, and consequences. Multivariate logistic regression was used to determine the predictors of adolescent girls and their mothers’ attitudes toward early pregnancy.

Results

The mean (SD: Standard Deviation) of knowledge of adolescent girls and their mothers about early pregnancy was 5.17 (3.11) and 5.57 (3.01), respectively (score range: 0 to 9). Most girls (94.1%) and mothers (87.1%) opposed pregnancy before 18. There was a statistically significant relationship between the knowledge and attitudes of girls (p < 0.001) and mothers (p < 0.001) about pregnancy at a young age. Adolescent girls and their mothers mentioned the lack of sufficient knowledge about sexual relations (57.4% of girls and 66.3% mothers agree) and the lack of knowledge about contraceptive methods (51.9% girl and 59.2% mother agree) important reasons for early pregnancy. Based on the multivariate logistic regression model and controlling for potentially confounding variables, girls whose parents were married under the age of 18 were about three times more likely to agree to early pregnancy than girls whose parents married over the age of 18 (OR = 3.10; 95% Cl: 0.90 to 10.69; p = 0.037). Also, mothers whose other children were married before 18 were almost five times more likely to agree to early pregnancy than women whose other children were not married before 18 (OR = 4.91; 95% Cl: 1.60 to 15.10; p = 0.045).

Conclusions

The current study results indicate that despite the negative attitude of adolescent girls and their mothers towards early pregnancy, they had a low level of knowledge about early pregnancy. Consequently, increasing the level of knowledge of girls and their families about the consequences of marriage and pregnancy at an early age and creating a culture to correct cultural and social misconceptions to prevent marriage and pregnancy of children can reduce the severity of this damage.
Overview of adjuvant radiotherapy on survival, failure pattern and toxicity in stage I to II endometrial carcinoma: a long-term multi-institutional analysis in China
Authors: Wang Wenhui , Wang Tiejun , Liu Zi , He Jianli , Sun Xiaoge , Zhong Wei , Zhao Fengjv , Li Xiaomei , Li Sha , Zhu Hong , Ma Zhanshu , Hu Ke , Zhang Fuquan , Hou Xiaorong , Wei Lichun , Zou Lijuan
Published: March 2022

Background

This research aimed to provide an overview of the impact of adjuvant vaginal brachytherapy (VBT) and external beam pelvic radiotherapy (EBRT) with or without VBT on survival in stage I to II EC patients in China from a long-term multi-institutional analysis.

Methods

We retrospectively analyzed stage I to II EC patients from 13 institutions treated between 2003 and 2015. All patients underwent surgical staging and received adjuvant RT. Patients were divided into groups of low-risk (LR), intermediate-risk (IR), high-intermediate-risk (HIR) and high-risk (HR). Survival statistics, failure pattern, and toxicity of different radiation modalities in different risk groups were analyzed.

Results

A total of 1048 patients were included. HR disease represented 27.6%, HIR 17.7%, IR 27.7% and LR 27.1%, respectively. Endometrioid adenocarcinoma (EAC) and non-endometrioid carcinoma (NEC) accounted for 92.8 and 7.2%. A total of 474 patients received VBT alone and 574 patients received EBRT with or without VBT.

As for EAC patients, the 5-year overall survival (OS), disease-free survival (DFS), local recurrence-free survival (LRFS), and distant metastasis-free survival (DMFS) rate was: 94.6, 90.4, 93.0 and 91.6%, respectively. For LR patients, EBRT (with or without VBT) seemed to be a risk factor. With the higher risk category, the survival benefit of EBRT gradually became remarkable. EBRT (with or without VBT) significantly increased DFS, LRFS and DMFS compared to VBT alone in the HR group (p < 0.05). Distant metastasis was the main failure pattern for all risk groups. As for NEC patients, the 5-year OS, DFS, LRFS and DMFS rate was: 93.4, 87.2, 91.7 and 89.3%, respectively. As for toxicity, EBRT (with or without VBT) significantly increased the incidence of grade 1–2 gastrointestinal, urinary, and hematological toxicity.

Conclusions

For stage I to II EC patients, EAC accounted for the majority and had better prognosis than NEC. For EAC patients, VBT alone resulted in comparable survival to EBRT in the LR, IR and HIR groups, while EBRT significantly increased survival in the HR group. EBRT had higher rate of toxicity than VBT.
Individual socioeconomic position, neighbourhood disadvantage and mental well-being: a cross-sectional multilevel analysis of mid-age adults
Authors: Mann Emily M. , Heesch Kristiann C. , Rachele Jerome N. , Burton Nicola W. , Turrell Gavin
Published: March 2022

Background

Socioeconomic disadvantage is associated with mental illness, yet its relationship with mental well-being is unclear. Mental well-being is defined as feeling good and functioning well. Benefits of mental well-being include reduced mortality, improved immune functioning and pain tolerance, and increased physical function, pro-social behaviour, and academic and job performance. This study aimed to explore the relationship between individual socioeconomic position (SEP), neighbourhood disadvantage and mental well-being in mid-age adults.

Methods

Multilevel modelling was used to analyse data collected from 7866 participants from the second (2009) wave of HABITAT (How Areas in Brisbane Influence healTh and activiTy), a longitudinal study (2007–2016) of adults aged 40–65 years living in Brisbane, Australia. Mental well-being was measured using the Warwick Edinburgh Mental Well-Being Scale (WEMWBS). Exposure measures were education, occupation, household income, and neighbourhood socioeconomic disadvantage.

Results

The lowest MWB scores were observed for the least educated (β = − 1.22, 95%CI = − 1.74, − 0.71), those permanently unable to work (β = − 5.50, 95%CI = − 6.90, − 4.10), the unemployed (β = − 2.62, 95%CI = − 4.12, − 1.13), and members of low-income households (β = − 3.77, 95%CI = − 4.59, − 2.94). Residents of the most disadvantaged neighbourhoods had lower MWB scores than those living in the least disadvantaged neighbourhoods, after adjustment for individual-level SEP (β = − 0.96, 95%CI = − 1.66, − 0.28).

Conclusions

Both individual-level SEP and neighbourhood disadvantage are associated with mental well-being although the association is stronger for individual-level SEP. This research highlights the need to address individual and neighbourhood-level socioeconomic determinants of mental well-being.