bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluating the Urban Heat Mitigation Potential of a Living Wall in Milan: One Year of Microclimate Monitoring
Authors: Ogut Ozge , Tzortzi Julia Nerantzia , Cavazzani Stefano , Bertolin Chiara
Published: June 2024

Urban heat island (UHI) mitigation and adaptation are urgent needs in a built environment, which requires us to search for sustainable solutions to limit the urban heat island effect and improve the energy efficiency of building envelopes. Among these solutions, vertical green structures (VGSs) have recently attracted significant attention for their potential to mitigate adverse effects, especially in densely built areas. This study presents a comprehensive data analysis of the microclimate of a living wall in Milan, Italy. Our aim was to evaluate this VGS’s performance in mitigating temperature increases caused by the UHI effect. In the literature, similar studies are limited to shorter monitoring periods (mostly in cooling seasons) and specific orientations (mostly facing south). However, the VGS presented in this case study here faces northwest and was continuously monitored for one calendar year. During this continuous in situ monitoring campaign, air temperature data from sensors either embedded in vegetation or exposed on a bare wall were collected and analysed over a whole calendar year, which is a novelty compared to the existing literature focused on VGSs due to the long duration. The findings indicate that the studied VGS has the ability to influence the outdoor microclimate depending on the season, the precipitation events, the wall exposure, the type of vegetation, and the vegetation’s phenological attributes. The analysis showed that the VGS consistently maintained cooler temperatures than the bare wall, with mean temperature differences ranging from 2.8 °C in autumn to 0.8 °C in spring through the winter. The vegetation acted as a natural insulator by reducing the air temperature during the hot summer and in early autumn, corresponding to the growing period of the vegetation. Thus, VGSs show potential to mitigate the global warming effect. These findings provide valuable insights on vegetation’s capability to act as a thermal regulator for sustainable urban planning and energy-efficient building design and retrofitting.
Assessing the Spatial Equity of Multi-Type Health Service Facilities: An Improved Method Integrating Scale Accessibility and Type Diversity
Authors: Zeng Yun , Zuo Jin , Li Chen , Luo Jiancheng
Published: June 2024

Ensuring the spatial equity of health service facilities (HSFs) is crucial for the well-being of residents. However, previous research has predominantly focused on the accessibility and equity of single-type facilities, neglecting the residents’ demand for diversified types of health services. This study proposes a multi-type, Gaussian-based, two-step floating catchment area method (MT-G2SFCA) to assess the comprehensive accessibility and equity of multi-type HSFs in different age groups in the Hedong District of Tianjin, with the Gini coefficient and the bivariate local Moran’s I. Furthermore, the key factors affecting the accessibility were explored through a geo-detector. The results indicate the following: (1) Neglecting the health benefits of facility type diversity can result in an underestimation of the accessibility and equity; (2) neglecting the differences in walking ability of the elderly can result in an overestimation of the accessibility and equity; and (3) the Pedestrian Route Directness is the key factor affecting the accessibility and equity in high-density urban areas, and especially that the facility density is the key factor for the elderly. This research emphasizes the impact of facility type diversity on the accessibility and equity of HSFs, which can offer more precise and holistic technical assistance and policy recommendations for optimizing the allocation of HSFs.
Trend Analysis of MODIS Land Surface Temperature and Land Cover in Central Italy
Authors: Ghaderpour Ebrahim , Mazzanti Paolo , Bozzano Francesca , Scarascia Mugnozza Gabriele
Published: June 2024

Land Surface Temperature (LST) is an important climate factor for understanding the relationship between the land surface and atmosphere. Furthermore, LST is linked to soil moisture and evapotranspiration, which can potentially alter the severity and regime of wildfires, landslide-triggering precipitation thresholds, and others. In this paper, the monthly daytime and nighttime LST products of Moderate Resolution Imaging Spectroradiometer (MODIS) are employed for the period 2000–2023 in order to find areas that have been cooling or warming in a region of great interest in Central Italy, due to its complex geological and geomorphological settings and its recent seismic sequences and landslide events. The annual MODIS land cover images for 2001–2022 are also utilized to investigate the interconnection between LST and land cover change. The results of the non-parametric Mann–Kendall trend test and its associated Sen’s slope reveal a significant nighttime warming trend in the region, particularly in July, linked to forest and woodland expansion. Grasslands toward the coastline with low elevation (less than 500 m a.s.l.) have experienced significant heat waves during the summer, with an LST of more than 35 °C. A significant negative correlation between the elevation and LST is observed for each calendar month. In particular, the daytime and nighttime LST have more than 80% correlation with elevation during winter and summer, respectively. In addition, nighttime warming and gradual drainage are noticed in Lake Campotosto. The results of this study could be useful for wildfire and landslide susceptibility analyses and hazard management.
Ice-versus-Steel Friction: An Advanced Numerical Approach for Competitive Winter Sports Applications
Authors: Grzemba Birthe , Pohrt Roman
Published: June 2024

Understanding and predicting the friction between a steel runner and an ice surface is paramount for many winter sports disciplines such as luge, bobsleigh, skeleton, and speed skating. A widely used numerical model for the analysis of the tribological system steel-on-ice is the Friction Algorithm using Skate Thermohydrodynamics (F.A.S.T.), which was originally introduced in 2007 and later extended. It aims to predict the resulting coefficient of friction (COF) from the two contributions of ice plowing and viscous drag. We explore the limitations of the existing F.A.S.T. model and extend the model to improve its applicability to winter sports disciplines. This includes generalizing the geometry of the runner as well as the curvature of the ice surface. The free rotational mechanical mounting of the runner to the moving sports equipment is introduced and implemented. We apply the new model to real-world geometries and kinematics of speed skating blades and bobsleigh runners to determine the resulting COF for a range of parameters, including geometry, temperature, load, and speed. The findings are compared to rule-of-thumb testimonies from athletes, previous numerical approaches, and published experimental results where applicable. While the general trends are reproduced, some discrepancy is found, which we ascribe to the specific assumptions around the formation of the liquid water layer derived from melted ice.
Research on the Milling Performance of Micro-Groove Ball End Mills for Titanium Alloys
Authors: Zhang Shihong , Shi Hu , Wang Baizhong , Ma Chunlu , Li Qinghua
Published: June 2024

Titanium alloys are widely used in various fields, but milling titanium alloy materials often leads to problems such as high milling forces, increased milling temperatures, and chip adhesion. Thus, the machinability of titanium alloys faces challenges. To improve the milling performance of titanium alloy materials, this study analyzes the effective working area on the surface of the milling cutter through mathematical calculations. We design micro-grooves in this area to utilize their friction-reducing and wear-resisting properties to alleviate the aforementioned issues. The effective working area of the ball end milling cutter’s cutting edge is calculated based on the amount of milling and the installation position between the milling cutter and the workpiece. By observing the surface structure of seashells, micro-grooves are proposed and designed to be applied in the working area of the milling cutter surface. The impact of the micro-groove area on the milling cutter surface and spindle speed on milling performance is discussed based on milling simulation and experimental tests. Experimental results show that the cutting force, milling temperature, and chip resistance to adhesion produced by micro-groove milling cutters are superior to conventional milling cutters. Milling cutters with three micro-grooves perform best at different spindle speeds. This is because the presence of micro-grooves on the surface of the milling cutter improves the friction state, promoting a reduction in milling force, while the micro-grooves also serve as storage containers for chips, alleviating the phenomenon of chip softening and adhesion to the cutter. When conducting cutting tests with a milling cutter that has three micro-grooves, the milling force is reduced by 10% to 30%, the milling temperature drops by 10% to 20%, and the surface roughness decreases by 8% to 12%.
Molecular Dynamics Simulation on Polymer Tribology: A Review
Authors: Yin Tianqiang , Wang Guoqing , Guo Zhiyuan , Pan Yiling , Song Jingfu , Ding Qingjun , Zhao Gai
Published: June 2024

A profound comprehension of friction and wear mechanisms is essential for the design and development of high-performance polymeric materials for tribological application. However, it is difficult to deeply investigate the polymer friction process in situ at the micro/mesoscopic scale by traditional research methods. In recent years, molecular dynamics (MD) simulation, as an emerging research method, has attracted more and more attention in the field of polymer tribology due to its ability to show the physicochemical evolution between the contact interfaces at the atomic scale. Herein, we review the applications of MD in recent studies of polymer tribology and their research focuses (e.g., tribological properties, distribution and conformation of polymer chains, interfacial interaction, frictional heat, and tribochemical reactions) across three perspectives: all-atom MD, reactive MD, and coarse-grained MD. Additionally, we summarize the current challenges encountered by MD simulation in polymer tribology research and present recommendations accordingly, aiming to provide several insights for researchers in related fields.
Anodic Dissolution Characteristics of GH4169 Alloy in NaNO3 Solutions by Roll-Print Mask Electrochemical Machining Using the Linear Cathode
Authors: Qin Ge , Li Shiwei , Han Lei , Liu Huan , Niu Shen , Ming Pingmei , Yan Liang
Published: June 2024

GH4169 alloy/Inconel 718 is extensively utilized in aerospace manufacturing due to its excellent high temperature mechanical properties. Micro-structuring on the workpiece surface can enhance its properties further. Through-mask electrochemical micromachining (TMEMM) is a promising and potential processing method for nickel-based superalloys. It can effectively solve the problem that traditional processing methods are difficult to achieve large-scale, high-precision and efficiency processing of surface micro-structure. This study explores the feasibility of electrochemical machining (ECM) for GH4169 using roll-print mask electrochemical machining with a linear cathode. Electrochemical dissolution characteristics of GH4169 alloy were analyzed in various electrolyte solutions and concentrations. Key parameters including cathode sizes, applied voltage and corrosion time were studied in the roll-print mask electrochemical machining. A qualitative model for micro-pit formation on GH4169 was established. Optimal parameters were determined through experiments: 300 μm mask hole and cathode size, 10 wt% NaNO3 electrolyte, 12 V voltage, 6 s corrosion time. The results demonstrate that the micro-pits with a diameter of 402.3 μm, depth of 92.8 μm and etch factor (EF) of 1.81 show an excellent profile and localization.
Analysis of Vibration Characteristics and Influencing Factors of Complex Tread Pattern Tires Based on Finite Element Method
Authors: Xu Mengdi , Ge Yunfei , Du Xianbin , Meng Zhaohong
Published: June 2024

The vibration of the tires significantly impacts a vehicle’s ride comfort and noise level; however, the current analysis of tire vibration characteristics often involves excessive simplification in their models, leading to a reduction in model accuracy. To analyze the tire vibrational properties and the influence of its design and service conditions, a combined modeling technology was developed to construct a three-dimensional (3D) finite element model of a 205/55R16 specification radial tire with intricate tread patterns. The accuracy and reliability of the simulation model was verified through vibration modal tests. Based on the vibration mode theory, the Lanczos method provided by ABAQUS was adopted to analyze the modal characteristics of the tire under free inflation and grounded conditions, and the effects of different inflation pressures, loads, operating conditions, and belt cord angles on the tire vibration characteristics were analyzed. The results indicate that grounding constraints will suppress the low order radial modal frequency of the tire and enhance the lateral modal frequency. The higher the order of the tire vibration mode, the greater the impact of inflation pressure. As the operating conditions change, the modal frequencies of all directions have the same trend of change, and as the ground load increases, the tire is prone to misalignment at lower lateral frequencies. The radial and lateral grounding modes of the tire are slightly affected by the change of the cord angle in the belt layer, but the circumferential grounding frequency decreases as the belt layer angle increases. These research findings offer a crucial foundation for the structural design of complex tread pattern tires, and also serve as a reference for addressing vibration and comfort issues encountered in the tire matching process.
An Innovative Method for Wind Load Estimation in High-Rise Buildings Based on Green’s Function
Authors: Song Lin , Yu Yang , Yu Jianxing , Wu Shibo , Ma Jiandong , Jin Zihang
Published: June 2024

High-rise buildings are inherently vulnerable to substantial wind-induced forces. The increasing complexity of building designs has posed challenges in calculating wind loads, while traditional methods involving physical models have proven to be intricate and time-consuming. In order to overcome these obstacles, this paper investigates a theoretical methodology aimed at streamlining the computation of wind loads. In the initial theoretical exploration, a simplified mathematical model based on Green’s function is introduced to take into account the interaction between wind loads and building geometry, while the model is not user-friendly and difficult to solve for complex polygonal buildings. To overcome this challenge, the study incorporates numerical simulations to extend the ideas and refine the methodology. To simplify the problem from a three-dimensional to a two-dimensional context, a bold tangential field assumption is made, assuming the wind pressure distribution remains similar across horizontal sections at different heights. The Schwarz–Christoffel formulation is then employed to facilitate the transformation. By integrating Green’s functions and conformal mapping to solve potential flow problems beyond the boundary layer, a comprehensive mathematical derivation is established. The above broadens the applicability of the mathematical theory and provides a new direction for estimations of high-speed wind load on buildings.
Numerical Recovering of Space-Dependent Sources in Hyperbolic Transmission Problems
Authors: Koleva Miglena N. , Vulkov Lubin G.
Published: June 2024

A body may have a structural, thermal, electromagnetic or optical role. In wave propagation, many models are described for transmission problems, whose solutions are defined in two or more domains. In this paper, we consider an inverse source hyperbolic problem on disconnected intervals, using solution point constraints. Applying a transform method, we reduce the inverse problems to direct ones, which are studied for well-posedness in special weighted Sobolev spaces. This means that the inverse problem is said to be well posed in the sense of Tikhonov (or conditionally well posed). The main aim of this study is to develop a finite difference method for solution of the transformed hyperbolic problems with a non-local differential operator and initial conditions. Numerical test examples are also analyzed.
Mathematical Modeling and Transmission Dynamics Analysis of the African Swine Fever Virus in Benin
Authors: Ayihou Sèna Yannick , Doumatè Têlé Jonas , Hameni Nkwayep Cedric , Bowong Tsakou Samuel , Glèlè Kakai Romain
Published: June 2024

African swine fever (ASF) is endemic in many African countries, and its control is challenging because no vaccine or treatment is available to date. Nowadays, mathematical modeling is a key tool in infectious disease studies, complementing traditional biological investigations. In this study, we propose and analyze a mathematical model for the transmission dynamics of African swine fever (ASF) in Benin that considers the free-living virus in the environment. We provide the theoretical results of the model. The study of the model is conducted by first proving that the model is well posed by showing the positivity and the boundedness of solutions as well as the existence and uniqueness of the solution. We compute the control reproduction number Rc as well as the basic reproduction number R0, which helps to analyze the extinction or the persistence of the disease in the pig population. We provide the global attractivity of the disease-free equilibrium and the endemic equilibrium and study their stabilities. After, we estimate some unknown parameters from the proposed model, and the sensitivity analysis is carried out to determine the parameters that influence the control reproduction number. Finally, through numerical simulations, in the current situation, we find that R0=2.78, which implies that the disease will not die out without any control measures and Rc=1.55 showing that the eradication of the disease highly depends on the control measures taken to reduce disease transmission.
Optimizing Inventory and Pricing for Substitute Products with Soft Supply Constraints
Authors: Meza Armando , Latorre Paolo , Bonacic Milena , López-Ospina Héctor , Pérez Juan
Published: June 2024

This paper presents a profit optimization model for substitute products in a competitive, time-sensitive market with scarcity and shifting user preferences. The model maximizes profit, considering production costs and inventory maintenance. It uses a discrete choice model to represent demand, sensitivity to price, availability, and changing preferences. A two-phase PSO-type metaheuristic solution tackles the nonlinear, recursive model, efficiently managing inventories and evolving consumer preferences. The model integrates production decisions, inventories, and sales prices, considering scarcity conditions and user preferences. It uses a multinomial logit for the consumers’ demand function with soft exogenous constraints, which influence utility and change consumption preferences and choices. This research offers a tool for companies to manage stock, production, and pricing in a context where goods are substitutes, providing a new perspective on business strategy.
Non-Dispersive Extraction of Chromium(VI) by Cyphos IL102/Solvesso 100 Using the Pseudo-Emulsion-Based Strip Dispersion Membrane Operation
Authors: Alguacil Francisco Jose
Published: June 2024

The removal of chromium(VI) from an acidic (HCl) medium through non-dispersive extraction with strip dispersion (NDXSD) was investigated using a microporous PVDF membrane support in a permeation cell. The ionic liquid Cyphos IL102 (phosphonium salt) in Solvesso 100 was used as an organic phase. In NDXSD, the stripping phase (NaOH) is dispersed in the organic phase on the cell side with an impeller stirrer adequate to form a strip dispersion. This pseudo-emulsion phase (organic + strip solutions) provides a constant supply of the Cyphos IL102/Solvesso 100 to the membrane phase. Various hydrodynamic and chemical parameters, such as variation in the feed and pseudo-emulsion stirring speeds, HCl and Cr(VI) concentrations in the feed phase, and carrier concentration, were investigated. Results indicated that the best chromium(VI) transport was obtained under the following conditions: feed and pseudo-emulsion stirring speeds of 1000 min−1 and 600 min−1, respectively; an HCl concentration in the feed phase of 0.1 M; a chromium concentration of 0.01 g/L in the same phase; and carrier concentration in the organic phase in the 2–5–10% v/v range. From the experimental data, several mass transfer coefficients were estimated: a bulk diffusion coefficient of 3.1·10−7 cm2/s and a diffusion coefficient of 6.1·10−8 cm2/s in the membrane phase and mass transfer coefficients in the feed (5.7·10−3 cm/s) and membrane phases (2.9·10−6 cm/s). The performance of the present system against other ionic liquids and the presence of base metals in the feed phase were investigated.
Microstructure and Pore Characteristics of a Double-Layered Pore Structure Powder Filter Fabricated by the WPS Process
Authors: Lee Min-Jeong , Kim Hyeon-Ju , Kang Du-Hong , Lee Jung Woo , Yun Jung-Yeul
Published: June 2024

In order to supply high-purity process gas in the semiconductor manufacturing process, a gas filter is used to remove particles that may be contained in the gas. However, because the gas filters currently in use have simple pore structures, there is a need to increase filtration efficiency through the development of filters with complex pore structures. In this study, a metal powder filter with double-layered pores was manufactured using a Wet Powder Spraying process (WPS) to increase the filtering efficiency of gas filters used in semiconductor manufacturing. The effects of the mixing ratio of spherical-shape and flake-shape powders and the rolling process on the filter’s characteristics were investigated. The filter’s performance, microstructure, and surface roughness were evaluated by measuring porosity and gas permeability. The results showed that as the ratio of flake-shaped powder decreased, the thickness of the coating layer and the porosity of the filter decreased. Additionally, it was observed that as the rolling process progressed, the non-uniform pore structure was oriented parallel to the cross-section of the filter regardless of the mixing ratio. Measurements found that the gas permeability of the uncoated filter support was the highest, and that gas permeability decreased as the proportion of spherical powder increased regardless of the average particle size of the mixed powder. Lower gas permeability was observed in rolled samples. A filtration efficiency of LRV 3 or higher was confirmed.
Study on Fracture Behavior and Toughening Mechanisms of Ultra-High-Strength Pipeline Steel
Authors: Li Ba , Zhou Xiaoshun , Jia Shujun , Chen Xiaoping , Fu Song , Zhao Dongliang , Zhang Haonan , Guo Jie
Published: June 2024

In this paper, a series of low-temperature CVN (Charpy V-notch impact test) and DWTT (drop-weight tear test) experiments were carried out to deal with the intensifying contradiction of strength and toughness of ultra-high-strength pipeline steel. The fracture behavior and toughening mechanisms of ultra-high-strength pipeline steel were investigated using scanning electron microscopy, transmission electron microscopy and backscattered electron diffraction systems. The results show that DWTT fractures in ultra-high-strength pipeline steel had a variety of unconventional morphological features compared to CVN fractures, including ridge protrusion in ductile fracture conditions and a large-size fracture platform in brittle fracture conditions. Therefore, DWTT fractures contained more information about the material fracturing process, and could better reflect the actual process of material fracturing. In ultra-high-strength pipeline steel, fine-grained granular bainite caused cracks to undergo large deflections or frequent small transitions, which consumed additional energy and improved toughness. In contrast, large-sized granular bainite, which consisted of low-angle grain boundaries, did not effectively prevent crack propagation when it encountered cracks, which was not conducive to improved toughness. Moreover, the M/A constituents in large-sized granular bainite aggregated, cracked, or fell off, which could easily lead to the formation of microcracks and was also detrimental to toughening.
Estimation Approach for a Linear Quantile-Regression Model with Long-Memory Stationary GARMA Errors
Authors: Essefiani Oumaima , El Halimi Rachid , Hamdoune Said
Published: June 2024

The aim of this paper is to assess the significant impact of using quantile analysis in multiple fields of scientific research . Here, we focus on estimating conditional quantile functions when the errors follow a GARMA (Generalized Auto-Regressive Moving Average) model. Our key theoretical contribution involves identifying the Quantile-Regression (QR) coefficients within the context of GARMA errors. We propose a modified maximum-likelihood estimation method using an EM algorithm to estimate the target coefficients and derive their statistical properties. The proposed procedure yields estimators that are strongly consistent and asymptotically normal under mild conditions. In order to evaluate the performance of the proposed estimators, a simulation study is conducted employing the minimum bias and Root Mean Square Error (RMSE) criterion. Furthermore, an empirical application is given to demonstrate the effectiveness of the proposed methodology in practice.
Unraveling the Binding Mode of Cyclic Adenosine–Inosine Monophosphate (cAIMP) to STING through Molecular Dynamics Simulations
Authors: Wang Meiting , Fan Baoyi , Lu Wenfeng , Ryde Ulf , Chang Yuxiao , Han Di , Lu Jiarui , Liu Taigang , Gao Qinghe , Chen Changpo , Xu Yongtao
Published: June 2024

The stimulator of interferon genes (STING) plays a significant role in immune defense and protection against tumor proliferation. Many cyclic dinucleotide (CDN) analogues have been reported to regulate its activity, but the dynamic process involved when the ligands activate STING remains unclear. In this work, all-atom molecular dynamics simulations were performed to explore the binding mode between human STING (hSTING) and four cyclic adenosine–inosine monophosphate analogs (cAIMPs), as well as 2′,3′-cGMP-AMP (2′,3′-cGAMP). The results indicate that these cAIMPs adopt a U-shaped configuration within the binding pocket, forming extensive non-covalent interaction networks with hSTING. These interactions play a significant role in augmenting the binding, particularly in interactions with Tyr167, Arg238, Thr263, and Thr267. Additionally, the presence of hydrophobic interactions between the ligand and the receptor further contributes to the overall stability of the binding. In this work, the conformational changes in hSTING upon binding these cAIMPs were also studied and a significant tendency for hSTING to shift from open to closed state was observed after binding some of the cAIMP ligands.
Pharmacokinetics and Tissue Distribution of Itampolin A following Intragastric and Intravenous Administration in Rats Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry
Authors: Sun Qi , Liang Jingwei , Zhang Qingyu , Wang Xuezhen , Zhao Nan , Meng Fanhao
Published: June 2024

Itampolin A, a natural brominated tyrosine alkaloid isolated from the sponge Iotrochota purpurea, has been shown to have good inhibitory effects in lung cancer cells as a p38α inhibitor. A simple, sensitive, and reliable ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS) method has been established, validated, and applied to the study of the pharmacokinetics and tissue distribution of itampolin A following intragastric and intravenous administration. Itampolin A and theophylline (internal standard, IS) were extracted by the simple protein precipitation technique using methanol as the precipitating solvent. Chromatographic separation was achieved by using the optimized mobile phase of a 0.1% formic acid aqueous solution and acetonitrile in the gradient elution mode. Itampolin A and IS were detected and quantified using positive electrospray ionization in the multiple reaction monitoring mode with transitions of m/z 863.9 → 569.1 for itampolin A and m/z 181.1 → 124.1 for IS, respectively. The assay exhibited a linear dynamic range of 1–1600 ng/mL for itampolin A in biological samples and the low limit of quantification was 1 ng/mL. Non-compartmental pharmacokinetic parameters indicated that itampolin A was well-absorbed into the systemic circulation and rapidly eliminated after administration. The apparent distribution volume of itampolin A was much higher after intragastric administration than that after intravenous administration. A tissue distribution study showed that itampolin A could be detected in different tissues and maintained a high concentration in the lung, which provided a material basis for its effective application in lung cancer. The pharmacokinetic process and tissue distribution characteristics of imtapolin A were expounded in this study, which can provide beneficial information for the further research and clinical application of itampolin A.
Pollutant Photodegradation Affected by Evaporative Water Concentration in a Climate Change Scenario
Authors: Rosso Arianna , Vione Davide
Published: June 2024

Evaporative water concentration takes place in arid or semi-arid environments when stationary water bodies, such as lakes or ponds, prevalently lose water by evaporation, which prevails over outflow or seepage into aquifers. Absence or near-absence of precipitation and elevated temperatures are important prerequisites for the process, which has the potential to deeply affect the photochemical attenuation of pollutants, including contaminants of emerging concern (CECs). Here we show that water evaporation would enhance the phototransformation of many CECs, especially those undergoing degradation mainly through direct photolysis and triplet-sensitized reactions. In contrast, processes induced by hydroxyl and carbonate radicals would be inhibited. Our model results suggest that the photochemical impact of water evaporation might increase in the future in several regions of the world, with no continent likely being unaffected, due to the effects of local precipitation decrease combined with an increase in temperature that facilitates evaporation.
Chemical Composition, Repellent, and Oviposition Deterrent Potential of Wild Plant Essential Oils against Three Mosquito Species
Authors: Abbas Muhammad Ghazanfar , Azeem Muhammad , Bashir Muhammad Umar , Ali Fawad , Mozūratis Raimondas , Binyameen Muhammad
Published: June 2024

In this study, the chemical composition, repellent, and oviposition deterrent effects of five plant essential oils (EOs) extracted from Lantana camara (Verbenaceae), Schinus terebinthifolia (Anacardiaceae), Callistemon viminalis (Myrtaceae), Helichrysum odoratissimum (Asteraceae), and Hyptis suaveolens (Lamiaceae) were evaluated against Aedes aegypti, Anopheles gambiae, and Culex quinquefasciatus. When tested at 33.3 µg/cm2, L. camara, S. terebinthifolia, C. viminalis, and H. odoratissimum were effective repellents against Ae. aegypti (89%, 91%, 90%, and 51% repellency, respectively), but they were less repellent against An. gambiae (66%, 86%, 59%, and 49% repellency, respectively). Interestingly, L. camara, S. terebinthifolia, C. viminalis, and H. odoratissimum exhibited 100% repellency against Cx. quinquefasciatus at 33.3 μg/cm2. In time-span bioassays performed at 333 μg/cm2, the EO of L. camara exhibited 100% repellence against Ae. aegypti and An. gambiae for up to 15 min and against Cx. quinquefasciatus for 75 min. The oviposition bioassays revealed that L. camara exhibited the highest activity, showing 85%, 59%, and 89% oviposition deterrence against Ae. aegypti, An. gambiae, and Cx. quinquefasciatus, respectively. The major compounds of L. camara, S. terebinthifolia, and C. viminalis were trans-β-caryophyllene (16.7%), α-pinene (15.5%), and 1,8-cineole (38.1%), respectively. In conclusion, the L. camara and S. terebinthifolia EOs have the potential to be natural mosquito repellents.
The Discovery of Selective Protein Arginine Methyltransferase 5 Inhibitors in the Management of β-Thalassemia through Computational Methods
Authors: Pokharel Bishant , Ravikumar Yuvaraj , Rathinavel Lavanyasri , Chewonarin Teera , Pongpom Monsicha , Tipsuwan Wachiraporn , Koonyosying Pimpisid , Srichairatanakool Somdet
Published: June 2024

β-Thalassemia is an inherited genetic disorder associated with β-globin chain synthesis, which ultimately becomes anemia. Adenosine-2,3-dialdehyde, by inhibiting arginine methyl transferase 5 (PRMT5), can induce fetal hemoglobin (HbF) levels. Hence, the materialization of PRMT5 inhibitors is considered a promising therapy in the management of β-thalassemia. This study conducted a virtual screening of certain compounds similar to 5′-deoxy-5′methyladenosine (3XV) using the PubChem database. The top 10 compounds were chosen based on the best docking scores, while their interactions with the PRMT5 active site were analyzed. Further, the top two compounds demonstrating the lowest binding energy were subjected to drug-likeness analysis and pharmacokinetic property predictions, followed by molecular dynamics simulation studies. Based on the molecular mechanics Poisson–Boltzmann surface area (MM-PBSA) score and molecular interactions, (3R,4S)-2-(6-aminopurin-9-yl)-5-[(4-ethylcyclohexyl)sulfanylmethyl]oxolane-3,4-diol (TOP1) and 2-(6-Aminopurin-9-yl)-5-[(6-aminopurin-9-yl)methylsulfanylmethyl]oxolane-3,4-diol (TOP2) were identified as potential hit compounds, while TOP1 exhibited higher binding affinity and stabler binding capabilities than TOP2 during molecular dynamics simulation (MDS) analysis. Taken together, the outcomes of our study could aid researchers in identifying promising PRMT5 inhibitors. Moreover, further investigations through in vivo and in vitro experiments would unquestionably confirm that this compound could be employed as a therapeutic drug in the management of β-thalassemia.
Exploring Human Emotions: A Virtual Reality-Based Experimental Approach Integrating Physiological and Facial Analysis
Authors: Bastida Leire , Sillaurren Sara , Loizaga Erlantz , Tomé Eneko , Moya Ana
Published: June 2024

This paper researches the classification of human emotions in a virtual reality (VR) context by analysing psychophysiological signals and facial expressions. Key objectives include exploring emotion categorisation models, identifying critical human signals for assessing emotions, and evaluating the accuracy of these signals in VR environments. A systematic literature review was performed through peer-reviewed articles, forming the basis for our methodologies. The integration of various emotion classifiers employs a ‘late fusion’ technique due to varying accuracies among classifiers. Notably, facial expression analysis faces challenges from VR equipment occluding crucial facial regions like the eyes, which significantly impacts emotion recognition accuracy. A weighted averaging system prioritises the psychophysiological classifier over the facial recognition classifiers due to its higher accuracy. Findings suggest that while combined techniques are promising, they struggle with mixed emotional states as well as with fear and trust emotions. The research underscores the potential and limitations of current technologies, recommending enhanced algorithms for effective interpretation of complex emotional expressions in VR. The study provides a groundwork for future advancements, aiming to refine emotion recognition systems through systematic data collection and algorithm optimisation.
Comparative Study of Callistemon citrinus (Bottlebrush) and Punica granatum (Pomegranate) Extracts for Sustainable Synthesis of Silver Nanoparticles and Their Oral Antimicrobial Efficacy
Authors: Ismail Enas , Mohamed Abubaker , Elzwawy Amir , Maboza Ernest , Dhlamini Mokhotjwa Simon , Adam Razia Z.
Published: June 2024

A comparative study was applied to investigate the potential of Callistemon citrinus (bottlebrush) flower extract (BBE) and Punica granatum (pomegranate) peel extracts (PPE) for the sustainable synthesis of the silver nanoparticles, Ag-BBE and Ag-PPE, respectively. The synthesis process of Ag NPs using the selected extracts was applied under optimized conditions. Hence, the effect of the selected plant’s type on the different characteristics of the synthesized green Ag NPs was investigated. The UV-Vis spectroscopy revealed the presence of the characteristic silver peaks at 419 and 433 nm of the Ag-BBE and Ag-PPE, respectively. The XRD spectra reported the fcc phase formation of Ag NPs. The TEM results highlighted the morphological features of the synthesized Ag NPs. with a size range of 20–70 nm, and with 10–30 nm for Ag-BBE and Ag-PPE, correspondingly. The Raman spectra revealed characteristic silver bands in the Ag-PPE and reflected some bands related to the natural extract in the Ag-BBE sample. The antimicrobial activity and statistical analysis investigation were conducted against four selected oral pathogens (Staphylococcus aureus (SA), Candida albicans (CA), Staphylococcus epidermidis (S. epi), and Enterococcus faecalis (EF)). Both tested extracts, BBE, and PPE, revealed potential effectivity as reducing and capping agents for Ag NP green synthesis. However, the synthesized NPs demonstrated different features, depending on the used extract, reflecting the influence of the plant’s biomolecules on the nanoparticles’ properties.
Long-Term Stable Cycling of Dendrite-Free Lithium Metal Batteries Using ZIF-90@PP Composite Separator
Authors: LYU Shuilan , Zhang Xin , Huang Sheng , Wang Shuanjin , Xiao Min , Han Dongmei , Meng Yuezhong
Published: June 2024

Lithium metal batteries (LMBs) are anticipated to meet the demand for high energy density, but the growth of lithium dendrites seriously hinders its practical application. Herein, we constructed a kind of composite separator (ZIF-90@PP) consisting of zeolite imidazole framework-90 (ZIF-90) and polypropylene (PP) to promote the uniform deposition of Li+ and inhibit the growth of lithium dendrites. The aldehyde groups interacting with TFSI− and the nitrogen-containing negative groups attracting Li+ of ZIF-90 can facilitate the dissociation of LiTFSI to release more Li+, thus alleviating the influence of space charge near the electrode surface and accelerating the transfer of Li+. Not only does the excellent electrolyte wettability of ZIF-90 enhance the electrolyte retention capacity of the separator, but the orderly nano-channels in ZIF-90 also restrict the free migration of anions and homogenize the distribution of Li+. Consequently, the functional separator achieves a long-term stable Li plating/stripping cycling for over 780 h at 2 mA cm−2. Moreover, an impressive average coulombic efficiency of 98.67% at 0.5 C after 300 cycles is realized by Li || LFP full cells based on ZIF-90@PP with a capacity retention rate of 71.22%. The high-rate and long cycling performance of the modified Li || LFP cells further demonstrates the advantages of the ZIF-90@PP composite separator.
Understanding Micronutrient Access through the Lens of the Social Ecological Model: Exploring the Influence of Socioeconomic Factors—A Qualitative Exploration
Authors: Stavitz James
Published: June 2024

Background: Micronutrient deficiencies disproportionately affect various populations, influenced by a complex interplay of socioeconomic factors. This study delves into the intricate relationship between socioeconomic status and micronutrient access, emphasizing the perceptions of affordability, availability, and the impact of social support networks. Methods: A qualitative research design was employed, using purposive sampling to enlist a diverse cohort of participants from varied socioeconomic backgrounds. The methodology comprised semi-structured interviews and focus groups to gather detailed insights into the participants’ experiences and views on micronutrient access. The analysis framework was based on the Social Ecological Model (SEM), enabling an in-depth examination of individual, interpersonal, community, and societal influences. Results: With 30 participants, aged 20–70, representing a range of unique characteristics such as differing health conditions, cultural backgrounds, and economic statuses, the study uncovered five key themes: Individual-Level Factors, Interpersonal Relationships, Community Environment, Societal Factors, and Intersectionality. These themes illustrate how personal dietary habits, social networks, community resources, and broader socioeconomic policies converge to shape micronutrient access, emphasizing the complex interplay of overlapping social identities and structural barriers. Conclusion: The findings highlight the need for holistic nutrition interventions that account for the extensive spectrum of socioeconomic determinants. This study not only enriches the theoretical underpinnings of the SEM but also provides actionable insights for crafting targeted strategies to enhance micronutrient access and ameliorate dietary inequities. It advocates for comprehensive public health initiatives attuned to the nuanced needs and hurdles faced by diverse demographic sectors.
Patient Safety Culture from a Nursing Perspective in a Chilean Hospital
Authors: Hurtado-Arenas Paulina , Guevara Miguel R. , González-Chordá Víctor M.
Published: June 2024

Patient safety culture is relevant both in the delivery of care and in the training of nursing staff, its purpose being to prevent and reduce risks associated with health care. This research aims to evaluate patient safety culture from the perspective of the nursing teams in a highly complex public hospital in the city of Valparaíso, Chile. A cross-sectional study with a quantitative approach applying descriptive, bivariate, and inferential statistical analysis was conducted on 259 nurses and nursing assistants from 13 adult medical–surgical units of the Carlos Van Buren hospital. The participants were obtained through a non-probabilistic convenience sample, answering the hospital survey on Patient Safety Culture version 2.0 (HSOPS 2.0), adapted to the Chilean population. The best-evaluated dimension was communication and receptivity; the worst was the support administrators provide for patient safety. This study identified the weaknesses and strengths of the hospital, the most worrying weakness being the shortage of human capital, material, and financial resources necessary to improve patient safety. This study was not registered.
Evaluation of Immune Exhaustion and Co-Inhibitory Receptor Expression in Mycobacterium avium Subspecies paratuberculosis (MAP) Seropositive Diarrhoeic Bovines
Authors: Sharma Shalini , Sharma Khushbu , Kumar Ram , Dayal Deen , Dhanda Shweta , Kumar Naveen , Chaubey Kundan Kumar , Singh Shoor Vir , Banger Sikander , Sharma Vishal
Published: June 2024

Mycobacterium avium subspecies paratuberculosis (MAP) infection leads to chronic, persistent granulomatous enteritis, causing prolonged diarrhoea and emaciation. The disease is managed using medications such as antibiotics, live vaccines, mycobacteriophage therapies and other treatments; however, a notable proportion of affected animals do not show improvement with this approach. We hypothesise that immunoinhibitory receptors TIM-3 (T cell immunoglobulin mucin protein-3) and PD-1 (Programmed death receptor 1) may be upregulated on Peripheral blood mononuclear cells (PBMCs) of MAP-seropositive bovines, potentially contributing to immune exhaustion. Samples (blood and faeces) were collected from 32 diarrhoeic bovines suspected of MAP infection; eight apparently healthy buffaloes from the dairy farm at Hisar, Haryana and from 14 cows (suffering from chronic diarrhoea, weakness and emaciation) housed in stray cattle shed. MAP infection was estimated using indigenous ELISA (i-ELISA), faecal IS900 PCR, culture and acid-fast staining. TIM-3 and PD-1 gene expression on PBMCs were determined using qRT-PCR. TIM3 expression was relatively higher (~400-fold, 330-fold, 112-fold, 65-fold and 16-fold) in 5 chronically diarrhoeic PBMCs samples (MAP-seropositive), and higher PD-1 expression (around ~7-fold, 1.75-fold, 2.5-fold, 7.6-fold) was recorded in 4 diarrhoeic MAP-seropositive animals, compared to apparently healthy and other MAP-seronegative diarrhoeic animals. High co-expression of TIM-3 and PD-1 levels was also recorded in chronically diarrhoeic, emaciated stray cattle. Understanding immune responses in field conditions might aid in the therapeutic management of paratuberculosis.
The Anti-Inflammatory Effect of SDF-1 Derived Peptide on Porphyromonas gingivalis Infection via Regulation of NLRP3 and AIM2 Inflammasome
Authors: Kim Si Yeong , Son Min Kee , Park Jung Hwa , Na Hee Sam , Chung Jin
Published: June 2024

(1) Background: Peptides are appealing as pharmacological materials because they are easily produced, safe, and tolerable. Despite increasing gum-care awareness, periodontitis is still prevalent and is influenced by factors like high sugar consumption, smoking, and aging. Porphyromonas gingivalis is considered a major etiologic agent of periodontitis and activates the NLR family pyrin domain containing 3 (NLRP3) but is absent in melanoma 2 (AIM2) inflammasomes, resulting in pro-inflammatory cytokine release. (2) Methods: We examined the anti-inflammatory effects of 18 peptides derived from human stromal cell-derived factor-1 (SDF-1) on THP-1 macrophages. Inflammation was induced by P. gingivalis, and the anti-inflammatory effects were analyzed using molecular biological techniques. In a mouse periodontitis model, alveolar bone resorption was assessed using micro-CT. (3) Results: Of the 18 SDF-1-derived peptides, S10 notably reduced IL-1β and TNF-α secretion. S10 also diminished the P. gingivalis-induced expression of NLRP3, AIM2, ASC (apoptosis-associated speck-like protein), caspase-1, and IL-1β. Furthermore, S10 attenuated the enhanced TLR (toll-like receptor) signaling pathway and decreased the phosphorylation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinases (MAPKs). In addition, S10 mitigated alveolar bone loss in our P. gingivalis-induced mouse model of periodontitis. (4) Conclusions: S10 suppressed TLR/NF-κB/NLRP3 inflammasome signaling and the AIM2 inflammasome in our P. gingivalis-induced murine periodontitis model, which suggests that it has potential use as a therapeutic treatment for periodontitis.