bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between carbohydrate quality index and general and central obesity in adults: A population-based study in Iran
Authors: Janbozorgi Nasim , Djafarian Kurosh , Mohammadpour Saba , Zareie Abyane Mahtab , Zameni Mahdi , Badeli Mostafa , Akbarzade Zahra , C. T. Clark Cain , Shab-Bidar Sakineh
Published: December 2021

Introduction: To determine whether dietary carbohydrates quality index (CQI), glycemic index, and glycemic load is associated with general and abdominal obesity. Methods: 850 participants, 20 to 59 years old, were enrolled in a cross-sectional study from five Tehran districts through health houses. The 168 items in the semi--quantitative food frequency questionnaire were used to assess dietary intake. The CQI was calculated by using the following four components: glycemic index, total fiber, solid carbohydrate to total carbohydrate ratio, and whole grains: total grains ratio. Results: After adjusting for confounding factors, the chance of obesity in men (OR=0.38, 95% CI 0.15to 0.95; P=0.04) measured by waist circumference (WC) was significantly lower in the fourth quintile of CQI in comparison with the first quintile. In addition, OR for obesity in men (OR=2.53, 95% CI0.52 to 1.37; P=0.04) was significantly 2.5 times higher among those in the fourth quintile of glycemic index compared with those in the lowest quintile. There was no significant association between dietary carbohydrates with general obesity in men and women. Conclusion: In summary, dietary CQI is significantly inversely related to central obesity in men,according to this study. Additionally, adherence to a diet with a higher glycemic index in men is positively associated with central obesity.
Physicochemical Changes of Contaminated Titanium Discs Treated With Erbium-Doped Yttrium Aluminum Garnet (Er:YAG) Laser Irradiation or Air-Flow Abrasion: An In Vitro Study
Authors: Amid Reza , Kadkhodazadeh Mahdi , Mojahedi Seyed Massoud , Gilvari Sarshari Maedeh , Zamani Zeinab
Published: December 2021

Introduction: Peri-implantitis is a common complication of dental implant treatment. A cause-and-effect relationship has been previously documented between microbial plaque and peri-implantitis and implant failure. A difference has been reported in the disinfection efficacy of erbium laser irradiation and air-flow abrasion for contaminated titanium surfaces. Also, the surface changes caused by lasers and air-flow abrasion have not been well studied. Thus, the purpose of this study was to compare the surface changes of contaminated titanium discs following decontamination by erbium-doped yttrium aluminum garnet (Er:YAG) laser irradiation and air-flow abrasion. Methods: Twenty-eight intact, sandblasted, and acid-etched (SLA) titanium discs were used. Twenty-four titanium discs were contaminated with Escherichia coli. Then, they were decontaminated by using Er:YAG laser irradiation and air-flow abrasion. Four discs remained intact. The mean and standard deviation of the contact angle and the weight percentage of aluminum, titanium, oxygen, carbon, phosphorus, and calcium were measured. Qualitative changes in surface topography of titanium discs were assessed by scanning electron microscopy (SEM). Results: The mean weight percentage of carbon in the air-flow abrasion group (4.98%) experienced a significant reduction compared with the contaminated (positive control) group (P=0.035). The contact angles were 46.54° and 38.67° in the laser and air-flow abrasion groups respectively, which were significantly lower than the value in the positive control group (75.15°) (P ≤0.001). SEM micrographs showed no significant change in the surface area in either technique. Conclusion: Air-flow abrasion was more successful in improving the surface characteristics of titanium discs with no alteration in surface topography or elements, compared with Er:YAG laser irradiation. Further studies regarding the safety of the Er:YAG laser for the decontamination of titanium surfaces are recommended.
Effects of Laser Acupuncture Therapy for Patients With Inadequate Recovery From Bell’s Palsy: Preliminary Results From Randomized, Double-Blind, Sham-Controlled Study
Authors: Ton Gil , Lee Li-Wen , Ho Wen-Chao , Tu Cheng-Hao , Chen Yi-Hung , Lee Yu-Chen
Published: December 2021

Introduction: Inadequate recovery from Bell’s palsy exists in a third of patients and results in physical and social impairments. The controversial nature of existing medical treatment options means that novel, alternative approaches are needed. In basic and clinical studies, low-level laser therapy (LLLT) has proven successful in regenerating peripheral nerves. Laser acupuncture therapy (LAT) is a rapidly growing treatment modality; however, its effectiveness for treating chronic Bell’s palsy is unknown. The feasibility of this innovative approach is the focus of this pilot study. Methods: A two-armed, parallel, randomized, investigator-subject-assessor-blinded, sham-controlled pilot study was conducted, and 17 eligible subjects were randomly allocated to either LAT (n=8) or sham LAT (n=9). The LAT group received three treatments each week for six weeks (18 sessions), while the sham LAT group received the same procedure but with a sham laser device. The change from baseline to week 6 in the social subscale of the Facial Disability Index (FDI) was the primary outcome. Secondary outcomes were changes in the House-Brackmann facial paralysis scale (HB), the Sunnybrook facial grading system (SB) and a stiffness scale at weeks 3 and 6. Results: A significant difference was shown in the HB score (P=0.0438) between baseline and week 3 and borderline significance was observed in both SB and stiffness scores from baseline to week 6 (P=0.0598 and P=0.0980 respectively). There was no significant difference in the FDI score between baseline and week 6. Conclusion: To the best of our knowledge, this clinical trial is the first such investigation on this topic. Our findings suggest that using LAT may have clinical effects on long-term complications of Bell’s palsy and justify further large-scale studies.
Study of common chromosomal abnormalities and Plasminogen activator Inhibitor(PAI-1) gene Polymorphism (5G/4G) and Prothrombin (F2)gene mutation(G20210A) in women with recurrent abortions in the North West of Iran
Authors: Bagheri Roya , Rahmani Seyed ali , Khoramifar Leila , Ilkhichoui Solmaz
Published: December 2021

Background. Parental chromosomal abnormalities as well as changes in genes encoding thrombophilic factors are common causes of recurrent abortions. One of the causes of thrombophilia is Factor II (F2) gene mutation (G20210A) and plasminogen activator inhibitor gene (PAI-1) polymorphism (4G/5G). Therefore, the present study aimed to investigate the frequency of chromosomal abnormalities and the association of thrombophilic gene polymorphisms in patients with abortion in northwestern Iran. Methods. In the present case-control study, cytogenetic analysis of 60 couples with a history of recurrent abortions was performed by the standard 72-hour culture of lymphocytes and G-banding. The polymorphism (5G/4G) of PAI-1 gene and the mutation (G20210A) of F2 genes were evaluated using RFLP-PCR and ARMS-PCR molecular methods, respectively. The obtained data were analyzed using statistical software. Results. No significant abnormalities affecting abortion were observed in cytogenetic studies; in the molecular study, the frequency of the 4G allele in patients and control groups were 54.2% and 33.3%, respectively; the frequency of 5G allele in the patients and control groups were 45.8% and 66.8%, respectively. The frequency of 5G/5G and 4G/5G genotypes is 25.0% and 41.6% in the patient group, and 55.0% and 23.3% in the control group, respectively. Also, the frequency of 4G/4G genotype in patients and controls were 33.3% and 21.6%, respectively. Conclusion. The results of this study show that there is a significant relationship between the frequency of the 4G allele of the PAI-1 gene with susceptibility to recurrent abortions in northwestern women, while no was relationship between F2 gene mutation and recurrent abortions was observed.
Colchicine for the Prevention of Myocardial Injury Following Elective PCI: A Randomized Clinical Trial
Authors: Aslanabadi Naser , Khiali Sajad , Joudi Saeid , Mamdouhi Milad , Entezari-Maleki Taher
Published: December 2021

Purpose: Considering the potential benefits of colchicine in coronary artery diseases, we aimed to carry out the present study to assess the impact of colchicine in the prevention of myocardial injury following elective percutaneous coronary intervention (PCI). Methods: A randomized, single-blinded, clinical trial was carried out on 102 patients undergoing elective PCI. All patients received the standard treatment prior to performing PCI. Moreover, the intervention group received 1, 0.5, 0.5 mg colchicine 12 to 18 hours before, 30-60 min before, and 12 hours after PCI, respectively. Serum concentrations of cardiac troponin I (cTnI) were measured before, 8, and 24 hours after the procedure to assess myocardial damage during PCI. Results: There were no significant differences in cTnI levels at baseline (P = 0.839), 8 (P = 0.729), and 24 hours (P = 0.398) after PCI between the intervention and the control groups. Likewise, no significant differences were seen regarding the mean differences of cTnI at baseline and 8 hours (P =0.190), at baseline and 24 hours (P = 0.780), and 8 and 24 hours after PCI (P = 0.680) in both groups. Conclusion: The study did not support the potential benefit of colchicine in the prevention of myocardial injury following elective PCI. Conducting well-designed randomized clinical trials with adequate sample size is recommended.
Antioxidant activity and nano delivery of the most frequently applied stilbene derivatives: A brief and recent review
Authors: Choiri Syaiful , Fitriastuti Rafifah , Faradiva Firdausi Z , Rahayu Windy V
Published: December 2021

As of recent, the appearance rate of several degenerative diseases and cancer influenced by oxidative stress continues to increase dramatically. Many compounds with high potential antioxidant activity have been explored and used extensively, i.e., as preventive or curative treatments. Stilbene and its derivates have high potential antioxidant activity contained in several botanical sources. To date, source exploration and antioxidant activity study of stilbene derivate has been reported. However, the nano-delivery of stilbene derivate meant to increase the antioxidant activity and stability is still a limited process. This review is devoted to brief and recent outlooks regarding the antioxidant activity and delivery system of the most frequently applied stilbene and its derivates, namely resveratrol and pterostilbene.
The impacts of method selectivity and binders on the properties of carbamazepine granules and their applications: A case study
Authors: Shete Rahul , Thorat Bhaskar , Amin Purnima
Published: December 2021

Background: Carbamazepine (CBZ) is a BCS II class drug, having many challenges in solubility, flowability, and compactibility. The study focused on the improvement of solubility, flow behavior, and drug release of carbamazepine. Methods: Low shear granulation (LSG), extrusion spheronization (ES), high shear granulation (HSG), fluid bed granulation (FBG), and hot melt granulation (HMG) methods were employed to prepare CBZ granules. Polyvinylpyrrolidone (PVP) K29/32, PVP K90, and Hydroxypropyl methylcellulose (HPMC) E5 were used as a binder. The drug to binder ratio was maintained in the proportion of 95:5. The nature of granules was analyzed by using X-ray Diffraction and Differential Scanning Calorimetry techniques. A powder flow tester was utilized to study the flow characteristics of the granules. Results: The HMG has successfully converted the crystalline structure of CBZ granules into an amorphous form. Dispersive and distributive mixing in the HMG has achieved better solid dispersion and fast drug release. The ES technique has reported the incompressible nature of the granules. PVP K90 and HPMC E5 were superior binders for imparting strength to the CBZ granules than PVP K29/32. The FBG has exhibited the free-flowing nature of granules due to their uniform and spherical shape. Conclusion: The HMG and FBG were the most effective methods that have remarkably improved drug release, flow properties, and compactibility of CBZ granules.
Synthesis of novel andostane-N-cyclohexyl-17-carboxamides, and their effect on the 5α-reductase isoform 2, the androgen receptor, and androgen-dependent glands
Authors: Lopez-Lezama Juan Carlos , Cabeza Marisa , Heuze Yvonne , Sánchez Araceli , Rojas José L. , Valencia-Islas Norma Angélica
Published: December 2021

Background: Benign Prostatic Hyperplasia (BPH), and Prostate Cancer (PCa) are androgen-dependent diseases. PCa is associated with excessive signalling of the androgen receptor (AR) due to the binding of 5α-DHT and T. BPH is related to high levels of 5α-dihydrotestosterone (5α-DHT), biosynthesized from testosterone (T) by 5α-reductase (5RD5A). The inhibition of 5RD5A and the blockage of AR are targets for their treatment. In this study, the synthesis and determination of biological activity of the new N-cyclohexyl-3β-hydroxyandrosta-5,16-diene-17-carboxamide (6), N-cyclohexyl-3-oxoandrosta-4,6,16-triene-17-carboxamide (7), and N-cyclohexyl-3-oxoandrosta-4,16-diene-17-carboxamide (8) were carried out to find new drugs to improve these afflictions. Methods: The synthesis of 6 to 8 was confirmed by spectroscopic and spectrometric analyses. Competitive binding assays determined the affinity of 6 to 8 to the AR. The inhibitory activity of 5RD5A isoform 2 (5RD5A2) (IC50) was established by the conversion of [3H]-T to [3H]-5α-DHT and it was compared with finasteride (FIN). The pharmacological effect of 6 to 8 was determined on the weight of the prostate and seminal vesicles glands of castrated hamsters treated with T, and on the diameter size of their flank organs. Results: Compounds 7 and 8 bound lightly (ca. 15 %) to AR. Comparing to FIN (IC50 = 8.5 nM), 6 to 8 (IC50 = 0.169, 0.105 and 0.155 nM, respectively) showed higher potency as inhibitors of 5RD5A2. Compound 6 decreased the prostate and seminal vesicles weight, as well as the hamsters' diameter flank organs. However, 7 only decreased the diameter of flank organs. Surprisingly, 8 increased these pharmacological parameters. Conclusion: Androstane-17-caboxamide 6 is a 5RD5A2 inhibitor that reduces the weight of androgen-dependent glands such as the prostate, suggesting it could be a lead for new drugs to treat BPH and PCa.
Andrographolide-loaded ethosomal gel for transdermal application: Formulation and in vitro penetration study
Authors: Martihandini Nooryza , Surini Silvia , Bahtiar Anton
Published: December 2021

Background: Andrographolide is a phytoconstituent with anti-inflammatory activity, however, the compound’s poor oral bioavailability has hindered its effective formulation for oral administration. This study, therefore, aims to develop an ethosome for improving andrographolide penetration through the transdermal delivery system. Methods: This study developed 3 ethosome formulas with different andrographolide-phospholipid weight ratios (1:8, 1:9; 1:10), using the thin-layer dispersion-sonication method. Subsequently, the ethosomes were evaluated for particle size, polydispersity index, zeta potential, morphology, as well as entrapment efficiency, and incorporated into a gel dosage form. Subsequently, an in vitro penetration study was performed using Franz diffusion cells for 24 hours and the stability of the gels at 5 ± 2°C, 30 ± 2°C, and 40 ± 2°C, were studied for 3 months. Results: The results showed the optimal formula was E2, a 1:9 weight ratio formula of andrographolide and phospholipid. Based on the transmission electron micrograph, E2 possessed unilamellar, as well as spherical-shaped vesicles, and exhibited superior characteristics for transdermal delivery, with a particle size of 89.95 ± 0.75 nm, polydispersity index of 0.254 ± 0.020, a zeta potential of -39.3 ± 0.82 mV, and entrapment efficiency of 97.89 ± 0.02%. Furthermore, the cumulative andrographolide penetration and transdermal flux for the ethosomal gel of E2 (EG2) were 129.25 ± 4.66 µg/cm2 and 5.16 ± 0.10 µg/cm2/hours, respectively. All the ethosomal gel formulations exhibited improved penetration enhancement of andrographolide, compared to the nonethosomal formulations. Also, the andrographolide levels in the ethosomal and nonethosomal gels after 3 months ranged from 98.13 to 104.19%, 97.93 to 104.01%, and 97.23 to 102.26% at storage temperatures of 5 ± 2°C, 30 ± 2°C/RH 65% ± 5%, and 40 ± 2°C/RH 75% ± 5%, respectively. Conclusions: This study concluded that encapsulation into ethosome enhances andrographolide delivery through the skin.
Recommendations to guide Vice Chairs for Education in serving as effective leaders
Authors: Dzara Kristina , Hampton Brittany Star , Hammoud Maya , Berkowitz Lori R.
Published: December 2021

Background: Vice Chairs for Education play an increasingly important role in academic medicine. They often serve in supportive roles overseeing educational initiatives and faculty development, ensuring that education remains prioritized. Literature in this area is limited, especially in obstetrics and gynecology. Prior literature has not been sufficiently directive in identifying best practices in role, mission, and scope for Vice Chairs for Education. Methods: We developed and facilitated a workshop at the Association of Professors of Gynecology and Obstetrics - Council on Resident Education in Obstetrics and Gynecology (APGO-CREOG) annual meeting in February 2020. We brought together a national group of medical education faculty to elucidate the role of Vice Chairs and offer recommendations. After utilizing a previously described technique for gathering and reporting group recommendations, notes from small- and large-group discussions were collated, coded, and collapsed. Results: Four broad recommendations resulted. First, role clarity must be ensured, ideally with co-developed guidelines for responsibility. Second, the Vice Chair for Education should be charged with identifying departmental educational initiatives, including faculty development, utilizing best educational practices. Third, Vice Chairs for Education should implement and evaluate educational initiatives to enhance faculty well-being and promote a robust clinical learning environment. Finally, they should integrate with other Vice Chairs for Education within their institution and as part of national organizations to collaborate and develop best practices. Conclusion: These serve as guidelines to establish success and increase impact and suggest the potential for a national body of Vice Chairs for Education leaders to improve local and national educational outcomes.
Değer Eğitimi Sürecinde Okul – Aile İşbirliği: Bir Nitel Çalışma
Authors: AKIN Zeliha , ÖZTÜRK Ergun
Published: December 2021

Bu araştırmanın amacı değer eğitiminde okul – aile işbirliğini değerlendirmek ve değer kazandırma sürecinde bu işbirliğinin önemini belirlemektir. Değerler eğitiminde okul ve aile işbirliğinin önemi hakkında derinlemesine bilgi etmek için nitel araştırma deseni benimsenmiştir. Çalışma grubunu Kayseri il merkezinde bulunan bir devlet okulunda 5. Sınıf derslerine giren 10 öğretmen ve 5. Sınıfta öğrencisi bulunan 10 veli oluşturmaktadır. Katılımcılar amaçsal örneklem yöntemi ile belirlenmiştir. Elde edilen veriler yarı yapılandırılmış görüşme formu kullanılarak raporlanmıştır. Görüşmeler ses kaydı ile alınmış, daha sonra her bir görüşmenin ses kaydı çözümlenmiş, elde edilen kodlar ve temalar tablolar halinde sunulmuştur. Bulgulara göre öğretmen ve velilerin değer tanımları benzerlik gösterdiği tespit edilmiştir. Araştırma sonuçlarına göre hem öğretmenler hem veliler öncelikli olarak dürüstlük, saygı ve sevgi değerlerinin öğretilmesi gerektiğini düşünmektedirler. Öğretmenlerden elde edilen görüşlere göre kazandırmakta zorluk çekilen değerler en çok dürüstlük, saygı ve paylaşma olurken veliler ise en çok dürüstlük ve sorumluluk değerlerini kazandırmakta zorluk çektiklerini belirtmişlerdir. Veliler ve öğretmenler birbirlerinden en çok dürüstlük, saygı ve sevgi değerlerini öğretmelerini beklemektedirler. Öğretmenlerin değer kazandırırken en çok model olma ve yaşantılardan örnekler verme yöntemlerini kullandığını; velilerin ise en çok öğüt verme, model olma ve yaşantılardan örnekler verme yöntemlerini kullandıklarını göstermektedir.
Los docentes y la recursividad en la educación multimodal
Authors: Macías Arroyo Franklin Gregorio , Ron Vargas María Elena , Olivo Román Diana Carolina
Published: December 2021

El planeta trasformó su modo de convivir con la llegada de la pandemia COVID-19, la educación también recibió afectaciones, que se convirtieron en oportunidades para el desarrollo de nuevas estrategias, es decir, que de la educación tradicional presencial nos ubicamos actualmente en los nuevos escenarios virtuales. El objetivo de la presente investigación es identificar la recursividad en la educación multimodal desde el ejercicio docente y la actividad áulica en el nivel de educación básica en el Ecuador. El estudio tuvo un enfoque cuanti-cualitativa, se utilizó un diseño paralelo convergente para recolectar datos. Se empleó una encuesta estructurada de 7 preguntas que se aplicó a docentes, padres de familia y estudiantes del sistema de educación general básica y de bachillerato de 22 provincias del Ecuador, para un total de 4589 personas. Como parte de las conclusiones, se determina que, en la educación básica en el Ecuador, los docentes contactan al estudiante y explican su contenido con la recursividad adaptada a los ambientes multimodales, por ello, la educación multimodal requiere de fortalecimiento y capacitación, se entiende también, que las instituciones educativas poco han contribuido para mejorar las diversas condiciones de educadores y educandos.
FAKTOR FAKTOR YANG MEMPENGARUH MINAT RUMAH SAKIT ISLAM DI JAWA TIMUR MEMILIH SOFTWARE APLIKASI “SI AISAH” PLJSIAS UMSURABAYA
Authors: Marina Anna , Warsidi  , Wahjono Sentot Imam , Balafif Sabri , Kurniawati Tri
Published: December 2021

This study aims to determine the interest of Islamic hospitals in East Java in choosing the sharia sofware application “SI AISAH” from the Sharia Accounting Information System Service Centre (PLJSIAS) University of Muhammadiyah Surabaya. This research is a quantitative research using Statistical Package for the Social Sciences Software IBM SPSS version 23. The variables used ini this study are: Sharia, User Safety, Prices, and User Friendly. The population in this study were the leader and employees of Islamic hospital in East Java  who were involved with the use of this sofware. Sampling using random sampling tehnique, with a total sample of 105 respondents. The results of the analysis show that the factors that influence the decision of Islamic hospitals in East Java to choose the “SI AISAH” software applicatin from PLJSIAS UMSurabaya are: Sharia (X1), User Safety (X2), Prices (X3), and User Friendly (X4). These four factors influence the decision of Islamic hospitals in East Java in choosing the “SI AISAH” software application only 69,9%, while the remaining 30,1% in influenced by other factor, and the most significants factor is the sharia factor (X1).
TANTANGAN DALAM MENGAKTIFKAN PEMBANGKIT TENAGA AIR SKALA KECIL
Authors: Saodah Siti , Zain Hermagasantos
Published: December 2021

Air adalah salah sumber tenaga listrik berdasarkan siklus alami. Air sebagai tenaga listrik telah lama dieksplorasi yang umumnya berskala besar karena lebih ekonomis. Akhir-akhir ini, pemanfaatan tenaga air berskala kecil mulai mendapat perhatian karena menipisnya sumber bahan bakar fosil. Secara teknis, pembangkit listrik tenaga air sekala kecil banyak yang menghadapi permasalahan, diantaranya adalah pemahaman tentang teknologi tenaga air dan pentingnya perawatan, dan kualitas listrik. Pengoptimalan tegangan sistem saluran dan dummy load diturunkan secara matematik secara jelas. Formulasi-formulasinya telah diterapkan di Pembangkit Listrik Tenaga Mikrohydro Suralaya, Jawa Barat, dengan memperbaiki tegangan sistem dari 220 V ke 1 kV untuk memenuhi tegangan dan rugi-rugi saluran. Sedangkan kapasitas dummy load  optimalnya adalah 26 kW, ini lebih kecil dari kapasitas terpasang 50 kW.
PENGARUH TEMPERATUR PANEL SURYA TERHADAP EFISIENSI PANEL SURYA
Authors: Utami Sri , Daud Aceng
Published: December 2021

Beberapa study menyatakan bahwa temperatur mempunyai peranan sangat penting dalam performansi panel surya baik dalam susunan seri maupun paralel. Eksperimen yang telah dilakukan menunjukkan pengaruh yang signifikan terhadap parameter kinerja panel surya. Penelitian ini bertujuan untuk mengetahui performa panel surya yang dipengaruhi oleh temperaturnya, kondisi intensitas matahari yang diterima serta proses pendinginan yang dilakukan pada panel surya sebagai variable yang dapat dikendalikan. Analisa dilakukan terhadap variable ini menunjukkan kinerja panel surya dilihat dari nilai efisiensi yang dihasilkan oleh panel surya. Performansi panel surya ini juga dimonitor secara jarak jauh dan ditampilkan melalui android, dengan IoT sebagai penghubungnya, untuk memudahkan monitoring dan kontroling sehingga sangat tepat jika akan diaplikasikan pada pembangkitan yang besar. Sistem yang dibangun selain untuk mengetahui pengaruh temperatur juga sangat tepat untuk digunakan sebagai maintenance pembangkita listrik tenaga surya. Dari penelitian yang telah dilakukan ini terdapat kenaikan daya keluaran dari PLTS dibandingkan dengan sistem tanpa sistem pendingin.
PENGARUH HARMONISA ARUS AKIBAT PENGGUNAAN BEBAN NON-LINIER TERHADAP HASIL PENGUKURAN kWhmeter ANALOG
Authors: Kastawan Made Wiwit
Published: December 2021

Penggunaan sumber tegangan non-sinusoidal atau beban non-linier pada sistem kelistrikan berdampak pada terbangkitkannya gelombang harmonisa arus. Gelombang harmonisa arus dapat mengakibatkan berbagai masalah, salah satunya adalah terjadinya kesalahan pada berbagai alat ukur yang terpasang pada sistem kelsitrikan tersebut. Dalam tulisan ini akan dibahas pengaruh gelombang harmonisa arus yang muncul sebagai akibat penggunaan beban-beban non-linier terhadap keakuratan hasil pengukuran konsumsi energi listrik oleh kWhmeter analog. Analisisnya dilakukan berdasarkan data yang diperoleh melalui pelaksanaan dua uji laboratorium berbeda yaitu pengukuran konsumsi energi listrik dengan beban linier (yang tidak menghasilkan gelombang harmonisa arus) dan pengukuran konsumsi energi listrik dengan beban non-linier (yang menghasilkan gelombang harmonisa arus dengan tingkat distorsi (total harmonic distortion, disingkat THD) berbeda. Hasil pengukuran konsumsi energi listrik dengan kWhmeter analog dan Power Quality Analyser (PQA) untuk masing-masing uji laboratorium akan dibandingkan untuk melihat perbedaannya dengan hasil pengukuran oleh PQA sebagai acuan.  karena PQA memiliki kemampuan untuk pengukuran true rms berbagai besaran listrik yang mengandung gelombang harmonisa. Analisis  terhadap data uji laboratorium menunjukkan bahwa harmonisa memiliki dampak atau pengaruh terhadap kesalahan pengukuran pemakaian energi oleh kWhmeter analog. Meski tidak meningkat secara signifikan namun semakin tinggi kandungan harmonisa arus maka akan semakin tinggi pula kesalahan pengukuran pemakaian energi listrik oleh kWhmeter analog. Lebih jauh, pengaruh harmonisa terhadap kesalahan pengukuran pemakaian energi oleh kWhmeter analog lebih signifikan untuk sistem kelistrikan tiga-fasa jika dibandingkan dengan sistem kelistrikan satu-fasa
PENGARUH TEMPERATUR TERHADAP PENGERINGAN BUAH MANGGA PADA CABINET DRYER
Authors: Susilawati  , Muslikhin Hidayat  , Prajitno
Published: December 2021

Buah mangga (Mangifera Indica Linn) merupakan komoditas musiman dan memiliki umur simpan yang pendek, sehingga untuk dapat menikmati produk buah mangga sepanjang tahun diperlukan proses pengawetan. Pengeringan menggunakan cabinet dryer merupakan salah satu cara untuk mengawetkan buah mangga. Variabel penelitian ini meliputi variabel bebas yaitu temperatur (40, 50, 60, 70 dan 80°C), variabel terikat yaitu: kandungan air, kecepatan pengeringan dan efisiensi pengeringan, dan variabel kontrol yaitu: waktu pengeringan buah (5 jam) dan debit aliran udara 0,0234 m3/s, konsentrasi larutan gula (50% selama 4 jam pada temperatur ruang) dan konsentrasi larutan kapur (2% selama 15 menit). Hasil penelitian menunjukkan bahwa makin tinggi temperatur semakin banyak kandungan air yang teruapkan, dan pengeringan yang optimal diperoleh pada temperatur 70°C dengan pencapaian efisiensi 22,79% dengan penggunaan kalor untuk memanaskan bahan sebesar 25,5 kJ, kalor untuk memanaskan udara sebesar 1,2 kJ, kalor untuk menguapkan air 63,4 kJ, kalor untuk memanaskan udara 238,7 kJ dan kalor yang diterima oleh cabinet dryer 12.932,5 kJ.
BOOST CHOPPER DUA FASA DENGAN FILTER LC KELUARAN
Authors: Achmad Mudawari
Published: December 2021

Penelitian ini mengusullan satu konsep baru dalam teknologi boost konverter DC ke DC tak terisolasi yang dilengkapi dengan filter LC. Topologi ini mempunyai riak keluaran yang rendah dan tegangan keluaran yang relatif stabil. Untuk dapat menghasilkan konverter dengan riak yang rendah, maka besarnya filter ini dioptimasi berdasarkan kriteria energi minimum yang tersimpan pada filter.
UNJUK KERJA TURBIN ANGIN TIPE POROS HORIZONTAL 3 SUDU BERDIAMETER 2,4 METER
Authors: Sapto Prajogo  , Memey Meida Sari
Published: December 2021

Indonesia merupakan negara kepulauan yang memiliki potensi sumber energi angin cukup tinggi. Pembuatan dan instalasi turbin angin di Indonesia masih belum berkembang pesat, dan penggunaannya masih pada jenis angin berkategori baik (>5 m/s). Pada penelitian ini dilakukan unjuk kerja turbin angin tipe poros horizontal 3 sudu dengan diameter 2,4 meter pada jenis angin marginal (kecepatan angin 3 - 4 m/s). Bahan yang digunakan untuk pembuatan sudu turbin adalah komposit. Berdasarkan hasil pengujian diperoleh efisiensi tertinggi pada saat pengujian tanpa beban sebesar 4,60% pada kecepatan angin 3,5 m/s dengan putaran 95,5 rpm, sedangkan pengujian saat berbeban sebesar 3,64% pada kecepatan angin 3,2 m/s dengan putaran 66,50 rpm.
SIFAT - SIFAT THERMAL KOIN 10 CENT HONGKONG
Authors: Sri Wuryanti
Published: December 2021

Pengujian sifat-sifat termal dapat dilakukan dengan berbagai cara seperti: metode analitik karakterisasi material menggunakan metode X-ray Fhluorescence (XRF), Scanning Electron Microscope (SEM) dan X-ray Difraction (XRD). Sifat-sifat termal yang diuji yakni kapasitas panas, konduktivitas panas dan massa jenis. Hasil pengujian pada koin l0 cent Hongkong yang diperoleh dengan tiga metode tersebut, hampir sama dengan perbedaan antara 10-25%. Nilai kapasitas panas yang tertinggi adalah menggunakan metode XRD yakni 0,3831 kJ/kg°C dan terendah menggunakan metode SEM yakni 0,3242 kJ/kg°C. Nilai konduktivitas panas yang tertinggi adalah menggunakan metode XRD yakni 385,7808 W/m°C dan terendah menggunakan motode SEM yakni 296,2998 W/m°C. Nilai massa jenis yang tertinggi adalah menggunakan metode XRD yakni 8,5703 kg/m3 terendah menggunakan motode SEM yakni 6,871 kg/m3.
A experiência Les Plongeons: o teatro em língua estrangeira como estratégia de ensino-aprendizagem
Authors: De Souza Teixeira Lucília , Enguel de Oliveira Vinícius , Guimarães Pereira Heloisa , Ziruolo Piovani Caroline , Silva Guilherme , Pereira da Silva Fabíola
Published: December 2021

O presente artigo tem por objetivo apresentar o impacto do uso de elementos teatrais no ensino-aprendizagem de língua francesa na disciplina "Francês III", da Graduação em Letras-Francês da Faculdade de Filosofia, Letras e Ciências Humanas da Universidade de São Paulo, no primeiro semestre de 2019, e a consequente criação de um grupo de teatro francófono. A proposta de integrar o teatro à sala de aula de língua partiu da Profa. Dra. Cristina Moerbeck Casadei Pietraroia e foi realizada pela atriz e diretora de teatro Giuliana Cerchiari de Andrade por meio de encontros semanais em que foram trabalhadas questões relacionadas à consciência corporal, à projeção de voz, à fonética e à fonologia do francês, além de exercícios para desenvolver a subjetividade e a confiança dos discentes. Cerchiari de Andrade parte das teorias desenvolvidas por Moshé Feldenkrais (1977), sobre consciência corporal, e por Claude Pujade-Renaud (1983), sobre o corpo discente em sala de aula, para integrar elementos das artes cênicas a exercícios corporais e vocais que permitam ao aprendiz de uma nova língua uma verdadeira imersão no difícil processo de aquisição linguística. Houve tamanha adesão ao trabalho proposto que, após o encerramento do semestre, um grupo de estudantes optou por sua continuidade através da formação da trupe “Les Plongeons”, que encenou a peça L'été de nouveau, de Laurent Von Wetter (2016), durante o 1º festival 10x10 de teatro francófono no Brasil, que aconteceu em Brasília, durante o XXIII Congresso Brasileiro de Professores de Francês, em novembro de 2019.
Autobiografias de leitor como instrumento de pesquisa: alguns caminhos e possibilidades de exploração
Authors: De Morais Filho Emerson Patrício , Pinheiro-Mariz Josilene
Published: December 2021

: Este artigo tem por objetivo apresentar alguns conceitos e noções basilares para a análise de autobiografias de leitores enquanto objeto de pesquisa, sob uma perspectiva da didática da literatura. Dessa forma, apresentamos alguns conceitos e noções desenvolvidas e teorizadas ao longo das últimas décadas, por especialistas da área, tais como: a noção de “identidade do leitor” (ROUXEL, 2013); as discussões acerca dos “modos de leitura” (PICARD, 1984; GERVAIS, 1992; JOUVE, 1993; CANVAT, 2007; RIFFATERRE, 1978, entre outros); a noção de “biblioteca interior” (LOUICHON, 2010); e algumas reflexões acerca do papel dos mediadores da leitura (PETIT, 2009) na formação do sujeito-leitor. As pesquisas demonstram que a produção desse gênero na formação de leitor tem se apresentado como um instrumento rico enquanto objeto de pesquisa, mas também muito eficaz enquanto instrumento de formação de leitores.
Éléments d’analyse du personnage de Lucien dans « L’Enfance d’un chef » de Jean-Paul Sartre
Authors: Garcia Karol Souza , Ponge Robert
Published: December 2021

Dans cet article, nous nous penchons sur « L’Enfance d’un chef », nouvelle publiée dans Le Mur (1939), recueil de Jean-Paul Sartre. Ce récit narre le parcours de Lucien Fleurier, fils d’un patron d’usine dans une ville provinciale, depuis sa petite enfance jusqu’à son entrée dans la vie adulte, d’environ 1910 jusque vers 1930. Notre travail propose une analyse de la formation du protagoniste, de son cheminement pour devenir un chef. Pour ce faire, nous commençons par une présentation de la nouvelle, de la narration, du narrateur ainsi que des parents de Lucien (pour comprendre la façon dont ils conçoivent son éducation, son dressage). Ensuite, nous étudions le personnage de Lucien, en examinant son processus d’apprentissage, ses expériences, ses doutes, ses soucis et ses transformations psychologiques. C’est un parcours non linéaire, avec des périodes où Lucien s’écarte du chemin que son père lui a tracé, écarts que finalement il rejette pour assumer son destin de futur chef. Ce faisant, il se rallie aux valeurs et comportements de sa famille, de son milieu, de sa classe et adhère à un groupe politique d’extrême droite, monarchiste, antisémite, violent et de tendance fasciste. Dans notre conclusion, nous signalons la manière dont ce récit de formation se situe dans son temps, dialogue avec son époque. Nous y mettons aussi en évidence l’emploi de l’ironie pour mettre en question, critiquer les choix de Lucien, les mœurs et les certitudes où il se réfugie et s’enferme.
Le français (langue et littérature) et l’idée de « modernité »
Authors: Chiss Jean-Louis
Published: December 2021

En choisissant pour thématique « Le français langue de la modernité », le congrès d’Aracaju nous invitait à méditer sur la relation entre une langue et un concept dont on sait l’inépuisable polysémie et le jeu de renvois, de croisements, de métamorphoses qu’il suscite.A la mémoire de Sabina Kundman.
L'intercompréhension (IC) : Des fondements d'une didactique de langues en contact aux interactions plurilingues sur la plateforme Miriadi
Authors: Franchon Claudine Marie Jeanne
Published: December 2021

Au début des années 1990 naissait un nouveau champ didactique résolument plurilingue et européen, celui de l'intercompréhension. Depuis, lieux et produits de formation et de recherche se sont multipliés (Galatea, Galanet, Galapro, Eurocomcenter, Redinter, Miriadi...). Si dans la première phase de son développement, toute une série de définitions ont surgi sans que l’on parvienne à s’accorder sur une formule optimale permettant d’en saisir les éléments essentiels, la plupart des spécialistes de l’intercompréhension s’accordent aujourd’hui sur une définition du concept dont le dénominateur commun est que l’intercompréhension est une forme de communication dans laquelle chaque personne s’exprime dans sa propre langue et comprend celle de l’autre. Cette définition permet de clarifier deux points : l’intercompréhension inclut la communication tant orale qu’écrite et exclut l’utilisation active de la langue étrangère. Cet article aura pour objectif de montrer à travers l'analyse qualitative de corpus extraits de la plateforme Miriadi, qui permet de générer un espace de formation adapté à son public, comment les principes fondateurs et la méthodologie de cette nouvelle approche à l'éducation plurilingue sont mis en pratique dans les échanges en ligne.
Analisis Kondisi Sosial Ekonomi Petani Terhadap Kerusakan Lahan di DAS Biyonga Kabupaten Gorontalo
Authors: Abdulah Sri Wulan , Jaya Risman , Dangkua Talha
Published: December 2021

This research was conducted at Biyonga Sub-watershed area of Gorontalo Regency. The aim of this research was to determine the effect of the socio-economic status of farmers on land damageand determine the behavior of farmers in land management in the Biyonga Sub-Watershed area, Gorontalo Regency. The researcher used descriptive quantitative method with Chi-Square test as data analysis technique. The results of the research showed that socio-economic factors that affecting land damage in the Biyonga Sub-Watershed are the educational status of farmers. They are predominantly elementary school graduates with lower income. This factor encouraged them to depend more on agricultural land. Farmers have suffiecient knowledge of good agricultural land management, but they do not care about the benefits and objectives of land conservation.
Potensi Beban Pencemaran Limbah Sektor Pertanian, Perkebunan dan Peternakan Terhadap DAS Bengawan Solo di Kabupaten Boyolali
Authors: Ningsih Sepfiana Dari , Khotimah Kusnul , Risnanti Fibula , Nugrahanti Dinda Ayu , Ahmad Radix Dzakiya , Maulana Rashyid Muttaqim
Published: December 2021

The Central Java Province is one of Province with a major agricultural livelihood. Central Java is also rice, corn, and soybean, which in 2019 the productivity of rice was 57.53 million per hectare. The rice land in Central Java is approximately 1.68 million hectares and provides 9.65 million tons of rice  (BPS , 2020). The agricultural sector also has a large multifunctional value in terms of improving food security, welfare of farmers, and also helps preserve the environment (Tannaim, Hasriyanti, & Nasiah, 2019). The goal for the study is to find out the potential burden of waste on agricultural, plantation, and livestock at Bengawan Solo Watershed in Boyolali Regency. This research using a quantitative descriptive method. Based on analysis of the livestock sector is by far the largest concentrations than other sectors, which could be proved that the highest wast-producing category of Cepogo dentures with a 2027 tons per year of body waste and a cost-burden of 26196 tons per year. This means that the livestock sector growing in Boyolali Regency could potentially produce a burden of pollution that could disrupt water quality in a Bengawan Solo Watershed.
Analysis of Peanut (Arachis Hypogeae L) Farming in Buae Village, Watang Pulu District, Sidenreng Rappang Regency
Authors: Rauf Andi Sulkifli , Irmayani Irmayani , Nurhaedah Nurhaedah
Published: December 2021

This study aims to determine (1) how much is the cost of peanut farming, (2) how much income is obtained from peanut farming, (3) how much is the feasibility level of peanut farming. This type of research used in this research is descriptive quantitative. The data collection methods used were observation, questionnaires, and interviews. The data analysis used was the B / C Ratio. Primary data which is the result of interviews with respondent farmers is tabulated to determine the cost and income of peanut farmers in Buae Village, the amount of costs used by peanut farmers is divided into three, among others: (1) the cost of labor outside the family (reel issued) of Rp. 5,465,316 and family workers (calculated) of Rp. 2,900,000, (2) the cost of production facilities is Rp. 2,321,457.31 (3) fixed costs of Rp. 345,299.67 total costs incurred by farmers of Rp. 8,132,073.21 / Ha. The amount of revenue is Rp. 18,071,018.06 / Ha. The amount of income received is Rp. 9,938,944.85 / Ha based on the calculation of B / C ratio shows 1.22 indicating that peanut farming in Buae Village is feasible to be developed where each expenditure is Rp. 1 can give you a profit of Rp. 1.22.
Early and late relapses of multiple myeloma after autologous haematopoietic stem cell transplantation
Authors: Mamaeva E. A. , Mendeleeva L. P. , Solovyev M. V. , Firsova M. V. , Kraizman A. A. , Arutyunyan N. K. , Abakumova A. V. , Startsev A. A. , Makunina E. A. , Kondratieva Y. A. , Kuzmina L. A.
Published: December 2021

Introduction. Autologous haematopoietic stem cell transplantation (auto-HSCT) is a highly effective treatment for multiple myeloma (MM). Auto-HSCT allows a signifi cant improvement of haematological response leading to higher overall survival and quality of life in MM patients. Nonetheless, the majority of patients develop relapse.

Aim — a comparison of clinical MM relapses developing at variant terms after auto-HSCT.

Patients and methods. A retrospective study enrolled 65 MM patients aged between 39 and 64 years. All patients had auto-HSCT during 2009–2019, all had achieved complete response (CR) or very good partial response (VGPR) and all since developed immunochemical MM relapse in laboratory evidence. Patients were divided in two cohorts by relapse term, the early (within 12 months of auto-HSCT) and late relapse.

Results. Early immunochemical relapse was diagnosed in 13 (20 %), late relapse — in 52 (80 %) patients. The dependence between relapse term and depth of post-auto-HSCT antitumour response has been determined. The proportion of CR patients was signifi cantly higher in late than in early relapse (55.8 vs. 23 %). In follow-up, 60 patients (92.3 %) were initiated on antirelapse therapy, all early relapse and 90.3 % late relapse patients. On day +100 of auto-HSCT, CR patients had later relapse vs. VGPR individuals (median 24 vs. 19.9 months, p = 0.08) with signifi cantly weaker paraprotein secretion resembling the clinical course of monoclonal gammopathy of unclear signifi cance (MGUS).

Conclusion. Auto-HSCT allows long-term control of the disease. A signifi cant prognostic factor is antitumour response on +100 day of auto-HSCT. Patients attaining CR have later relapse progressing in a MGUS-like manner. Patients with late indolent relapse can be managed long-term without antitumour therapy.
Application of conditioned medium from mesenchymal stromal cells in the protocol for ex vivo production of megakaryocytes and platelets
Authors: Klyuchnikov D. Yu. , Yazykova M. Yu. , Stepanov A. A. , Volchkov S. E. , Tyumina O. V.
Published: December 2021

Introduction. Of interest is the use of a conditioned medium from mesenchymal stromal cells in order to increase the expansion of CD34+  hematopoietic stem cells (HSCs).

Aim — to analyze the effi cacy of two methods of ex vivo production of human megakaryocytes and platelets from CD34+ cord blood HSC using conditioned media from mesenchymal stromal cells and IMDM. Methods. Two cultivation methods that differ from each other by medium composition were compared. As a control of antigen expression of the donor, venous blood platelets were used. CD34+ HSCs were isolated from mononuclear fraction of cord blood using the immunomagnetic selection technique. The resulting cells were introduced at a concentration of 1 × 104  cells/mL into 24-well plates and cultured at 39 °C and 10 % CO2  for the first 7 days, after which the conditions were changed to 37 °C and 5 % CO2  and cultured for 14 days. In Group 1, up to day 7, the culture was performed using conditioned medium from mesenchymal stromal cell containing TPO (30 ng/mL), SCF (2 ng/mL), IL-6 (7.5 ng/mL), IL-9 (13.5 ng/mL), and in Group 2 a IMDM medium with the same cytokine cocktail was used. The cells were calculated using haemocytometer. CD34, CD41a, CD42b expression was evaluated using fl ow cytometry. Statistic data was processed with using R-language. The differences were evaluated as statistically signifi cant at signifi cance level p < 0.05.

Results. Megakaryocyte production was observed starting from day 7 of culture. The expression level using conditioned medium from mesenchymal stromal cells (Group 1) according to CD41a was 5.84 ± 0.33 % versus 10.43 ± 1.08 % using IMDM medium (Group 2). On day 13 the ratio increased up to 42.05 ± 1.71 % in Group 1 and 61.78 ± 1.71 % in Group 2. CD41a+ megakaryocytes of Group 1 expressed the CD42b marker at the level of 96.85 ± 1.06 % versus 88.7 ± 0.56 % in Group 2. With the application of MSC conditioned medium the average number of nucleated cells was signifi cantly higher on the day 11 and it was equal 326.016 ± 1.86 × 104  cells/mL vs 197.26 ± 10.55 × 104  cells/mL in IMDM medium. Proplatelet formation was observed with microscopy staring from the day 12. The ratio of CD41a+ /CD42b+  platelets was 59.5 ± 3.85 % in conditioned medium, 65.9 ± 8.72 % in IMDM, and 96.11 ± 0.89 % in control platelets derived from venous blood.

Conclusion. It was demonstrated that the use of MSC conditioned medium leads to an increase in the expansion of nucleated cells, however it decreases the rate of differentiation in megakaryocytes.