bluuebunny/crossref_metadata_2025 huggingface dataset:
Geotechnical Study of Raspadalica Cliff Rockfall, Croatia
Authors: Udovič Dalibor , Kordić Branko , Arbanas Željko
Published: June 2022

The Raspadalica Cliff is an almost vertical 100 m high limestone cliff with a railway line at its foot and is known for numerous rockfall occurrences in the past. This article presents the results of the geotechnical study of the cliff based on a traditional geological and geotechnical field survey and remote sensing analysis. Both the traditional geological and geotechnical field survey and remote sensing surveys and analyses enabled the establishment of the structural model of the Raspadalica Cliff and the determination of the discontinuity sets and discontinuity features, such as orientation, spacing, persistence, roughness, discontinuity wall strength, aperture, degree of weathering of discontinuity wall, seepage conditions, and the presence and hardness of discontinuity filling. Kinematic analyses were performed on five cliff zones with slightly different structural features, indicating a relatively low probability of typical failures in the cliff rock mass that precede the rockfall occurrences. Although rockfall phenomena from the cliff face are relatively frequent, the kinematic analyses did not indicate a high probability of their occurrence. The aim of this manuscript is to make scientists and practitioners aware that investigation of rock mass cliffs and possible rockfall failures must not be based on usual methods without critical review of the obtained results and consequences. The combined use of traditional geological and geotechnical methods and more commonly used advanced remote sensing methods leads to better modelling, while the analysis of more associated failure modes can explain the triggering of rockfall.
The Effect of Feldspathic Thickness on Fluorescence of a Variety of Resin Cements and Flowable Composites
Authors: Pereira Joana Santos de Cunha , Reis José Alexandre , Martins Francisco , Maurício Paulo , Fuentes M. Victoria
Published: June 2022

(1) Background: The shade of resin-based materials and ceramic thickness influence the optical color of laminate restorations. The purpose of this study is to evaluate—in vitro—the effect of resin-based cement shade and ceramic thickness on fluorescence of feldspathic laminate veneers; (2) Methods: 180 samples of feldspathic ceramic A2 shade with two different thicknesses (0.5 and 0.8 mm) were obtained. The samples were cemented to composite resin substrates with one of the following materials in different shades (n = 10): resin cement (Variolink Esthetic in Light, Neutral and Warm shades; or RelyX Veneer in B0.5 /white, Translucent and A3 Opaque/yellow opaque shades); flowable composite resin (G-aenial Flo in A2 and A3 shades) or a pre-heated composite resin (Filtek Supreme XTE, A3 body shade). The fluorescence spectra were obtained by means of a spectrofluorometer. Two-way ANOVA, Tukey, and Student’s t-tests were performed (α = 0.05); (3) Results: Fluorescence values were significantly influenced by the resin-based agent tested (p < 0.001), the thickness of ceramic (p < 0.001), and their interaction (p < 0.001). The lowest fluorescence values were achieved by RelyX Veneer resin cement regardless its shade and the ceramic thickness; (4) Conclusions: both the shade of resin-based agent and the feldspathic ceramic thickness influenced the fluorescence of laminate restorations.
A Unified Knowledge Extraction Method Based on BERT and Handshaking Tagging Scheme
Authors: Yang Ning , Pun Sio Hang , Vai Mang I , Yang Yifan , Miao Qingliang
Published: June 2022

In the actual knowledge extraction system, different applications have different entity classes and relationship schema, so the generalization and migration ability of knowledge extraction are very important. By training a knowledge extraction model in the source domain and applying the model to an arbitrary target domain directly, open domain knowledge extraction technology becomes crucial to mitigate the generalization and migration ability issues. Traditional knowledge extraction models cannot be directly transferred to new domains and also cannot extract undefined relation types. In order to deal with the above issues, in this paper, we proposed an end-to-end Chinese open-domain knowledge extraction model, TPORE (Extract Open-domain Relations through Token Pair linking), which combined BERT with a handshaking tagging scheme. TPORE can alleviate the nested entities and nested relations issues. Additionally, a new loss function that conducts a pairwise comparison of target category score and non-target category score to automatically balance the weight was adopted, and the experiment results indicate that the loss function can bring speed and performance improvements. The extensive experiments demonstrate that the proposed method can significantly surpass strong baselines. Specifically, our approach can achieve new state-of-the-art Chinese open Relation Extraction (ORE) benchmarks (COER and SAOKE). In the COER dataset, F1 increased from 66.36% to 79.63%, and in the SpanSAOKE dataset, F1 increased from 46.0% to 54.91%. In the medical domain, our method can obtain close performance compared with the SOTA method in the CMeIE and CMeEE datasets.
An Analysis of Axial Magnetic Coupling Force and Torque Dependencies on Its Structure Parameters Using a 3D FEM
Authors: Lukočius Robertas , Vilkauskas Andrius , Marčiulionis Povilas , Grigaliūnas Valdas , Nakutis Žilvinas , Deltuva Ramūnas
Published: June 2022

This paper presents research on the mechanical characteristics of a synchronous axial magnetic coupling. The influence of the coupling structure on torque and axial force was analyzed. The considered parameters of the structure include the half-clutch diversity, the air-gap length between adjacent magnets, the magnetic characteristics of the backings’ material, and the shape of the backings. It was discovered that the ferromagnetic backings that partially shroud magnets of the coupling cause a significant decrease of the maximum torque. The maximum torque and the maximum axial force decrease in nonlinear manner in response to the increasing magnets’ height diversity, and the sensitivity of the parameters is larger in the upper range of the diversity. It was also disclosed that the air-gap length between the adjacent magnets has a minor influence on torque if the total volume of magnets is constant. A quantitative comparison of the maximum torque and maximum axial force for the couplings with both ferromagnetic backings, one ferromagnetic backing and with non-ferromagnetic backings is provided. The results were obtained using a 3D FEM numerical simulation. Physical experiments were performed for the numerical model verification.
Efficiency Enhancement Design Approach in the Side Wing of a FSAE Car Utilizing a Shutter-Like Fairing Structure
Authors: Qi Xiaojing , Ou Yuxin , Zhang Hance , Wang Da
Published: June 2022

Aerodynamical design is one of the critical technologies in race car engineering, and favorable race car aerodynamics is supposed to provide sufficient negative lift force and keep the center of pressure in the vicinity of center of mass. Taking the Formula Society of Automotive Engineers (FSAE) cars as an example, side wing structure is frequently adopted for better grip in the mid-back of short wheelbase, open wheel race cars. This research designs a shutter-like fairing structure and utilizes it to weaken the vorticity and reinforce the pressure of side wing flow field. The sensitivity of side wing aerodynamic efficiency to shutters’ key parameters is analyzed, and optimized shutters’ key parameters for a prototype FSAE race car are obtained through computational fluid dynamics simulations. Results indicate that over 10% enhancement in side wing aerodynamic efficiency can be achieved by applying optimized shutters.
Fatty Acid Content, Lipid Quality Indices, and Mineral Composition of Cow Milk and Yogurts Produced with Different Starter Cultures Enriched with Bifidobacterium bifidum
Authors: Paszczyk Beata , Tońska Elżbieta
Published: June 2022

This study aimed to analyze the composition of fatty acids, with particular emphasis on the content of cis9trans11 C18:2 (CLA) acid, the content of minerals, and lipid quality indices in raw milk, pasteurized milk, and in yogurts produced with selected starter cultures enriched with Bifidobacterium bifidum. The GC-FID method was used to determine the fatty acid composition of those dairy products. To analyze the contents of microelements (copper, manganese, iron, and zinc) and macroelements (magnesium, calcium) flame atomic absorption spectrometry was used. The content of phosphorus was determined with the usage of the colorimetric method and the contents of sodium and potassium with emission method. Data analysis showed that such technologies as milk pasteurization and milk fermentation had a significant impact on the fatty acid profile and contents of micro- and macroelements. The lipid quality indices: atherogenicity index (AI), index thrombogenicity (TI), hypocholesterolemic/hypercholesterolemic index (H/H), and (n − 6)/(n − 3) ratio, were at similar levels in raw and pasteurized milk and yogurts produced. Starter culture type affected the content of cis-9, trans-11 CLA C18:2 acid in yogurts. Out of the starter cultures applied in the study, only the FD-DVS YC-X16 Yo-Flex starter culture with BB-12 caused a significant (p < 0.05) increase in CLA content. The CLA content of the yogurts produced using this starter culture was 2.67 mg/g fat. In raw milk, pasteurized milk, and the second batch of yogurts, the content of cis-9, trans-11 C18:2 acid was significantly lower and reached 2.26 mg/g fat, 2.17 mg/g fat, and 2.30 mg/g fat, respectively. The study indicated that, when it comes to being a source of minerals, yogurts were better than milk. Yogurts were also characterized by significantly (p < 0.05) higher contents of all micro- and macroelements taken into account in this study than the raw milk used to produce them.
Antioxidant and Enzyme Inhibitory Properties, and HPLC–MS/MS Profiles of Different Extracts of Arabis carduchorum Boiss.: An Endemic Plant to Turkey
Authors: Uba Abdullahi Ibrahim , Zengin Gokhan , Montesano Domenico , Cakilcioglu Ugur , Selvi Selami , Ulusan Musa Denizhan , Caprioli Giovanni , Sagratini Gianni , Angeloni Simone , Jugreet Sharmeen , Hasan Mohammad Mehedi , Mahoomodally Mohamad Fawzi
Published: June 2022

In this study, six extracts of Arabis carduchorum prepared from solvents of varying polarity (water, methanol, ethyl acetate, dichloromethane, and n-hexane) were investigated for their chemical profiles and total phenolic and flavonoid contents (TPC/TFC) using HPLC–MS/MS and spectrophotometric/colorimetric assays, respectively, along with the assessment of their antioxidant and enzyme inhibitory effects. In general, the polar extracts (methanol, water, and infusion) showed higher TPC/TFC than the other extracts (range: 13.73–26.62 mg GAE/g; 2.66–52.95 mg RE/g, respectively). The total antioxidant capacity of the polar extracts ranged from 0.90–1.85 mmol TE/g in phosphomolybdenum assay, while the free radical scavenging potential ranged from 4.36–32.13 mg TE/g and 12.58–67.73 mg TE/g in DPPH and ABTS assays, respectively. While the water and infuse extract inhibited only butyrylcholinesterase (2.68 and 2.39 mg GALAE/g, respectively), the other extracts were found to inhibit both acetyl- and butyryl-cholinesterases (0.96–2.73 mg GALAE/g and 1.86–5.11 mg GALAE/g, respectively). On the contrary, all extracts exhibited anti-tyrosinase (40.24–59.22 mg KAE/g) and anti-amylase (0.09–0.63 mmol ACAE/g) activities. Overall, this study highlighted the effect of solvent polarity on the extraction of bioactive compounds and the biological properties of the extracts of A. carduchorum; hence, the results obtained could be used to guide optimum extraction in future studies.
A Deep Convolutional Generative Adversarial Networks-Based Method for Defect Detection in Small Sample Industrial Parts Images
Authors: Gao Hongbin , Zhang Ya , Lv Wenkai , Yin Jiawei , Qasim Tehreem , Wang Dongyun
Published: June 2022

Online defect detection in small industrial parts is of paramount importance for building closed loop intelligent manufacturing systems. However, high-efficiency and high-precision detection of surface defects in these manufacturing systems is a difficult task and poses a major research challenge. The small sample size of industrial parts available for training machine learning algorithms and the low accuracy of computer vision-based inspection algorithms are the bottlenecks that restrict the development of efficient online defect detection technology. To address these issues, we propose a small sample gear face defect detection method based on a Deep Convolutional Generative Adversarial Network (DCGAN) and a lightweight Convolutional Neural Network (CNN) in this paper. Initially, we perform data augmentation by using DCGAN and traditional data enhancement methods which effectively increase the size of the training data. In the next stage, we perform defect classification by using a lightweight CNN model which is based on the state-of-the-art Vgg11 network. We introduce the Leaky ReLU activation function and a dropout layer in the proposed CNN. In the experimental evaluation, the proposed framework achieves a high score of 98.40%, which is better than that of the classic Vgg11 network model. The method proposed in this paper is helpful for the detection of defects in industrial parts when the available sample size for training is small.
RCC Structural Deformation and Damage Quantification Using Unmanned Aerial Vehicle Image Correlation Technique
Authors: Kumarapu Kumar , Mesapam Shashi , Keesara Venkat Reddy , Shukla Anoop Kumar , Manapragada Naga Venkata Sai Kumar , Javed Babar
Published: June 2022

Reinforced cement concrete (RCC) is universally acknowledged as a low-cost, rigid, and high-strength construction material. Major structures like buildings, bridges, dams, etc., are made of RCC and subjected to repetitive loading during their service life for which structural performance deteriorates with time. Bridges and high-rise structures, being above ground level, are hard to equip with the contact mechanical methods to inspect strains and displacements for structural health monitoring (SHM). A non-contact, optical and computer vision based full field measuring technique called digital image correlation (DIC) technique was developed in the recent past to specifically evaluate bridge decks. Generally, optical images of structure in field conditions are not acquired precisely perpendicular to the object, which instinctively affects the deformation results obtained during loading conditions. An unmanned aerial vehicle (UAV) equipped with DIC vision-based technique acts as a rapid and cost-effective tool to quantify the serviceability of bridges by measuring strains and displacements at inaccessible locations. In this study, a non-contact unmanned aerial vehicle image correlation (UAVIC) technique is used on a scaled bridge girder and a contact method of measuring deformations with a dial gauge. Both investigations are correlated for accuracy assessment, and it is understood that results in laboratory conditions are 90% accurate. Similarly, the UAVIC technique is also performed on a rail over the bridge in the field conditions to understand the feasibility of the proposed method and evaluate damage quantification of it.
Exploring the Early Impacts of the COVID-19 Pandemic on the Construction Industry in New York State
Authors: Ilatova Esther , Abraham Yewande S. , Celik Bilge Gokhan
Published: June 2022

The COVID-19 pandemic severely impacted many industries on a global scale. Expectedly, the construction industry was not left out as non-essential construction was halted, strict health and safety protocols were introduced, and businesses were disrupted. New York City was the epicenter of the pandemic at its onset in the United States, and the pandemic had different impacts on workers based on their work location and role. This study utilized a survey including twenty-five statements to explore the initial impacts of the COVID-19 pandemic on the construction industry in New York State, analyzing its effects on sixty-one construction industry professionals, their projects, and firms, also considering their work location and role in the construction process. The most severe impacts were on construction schedules and in-person meetings. Those who worked in New York City had more difficulty complying with the increased health and safety regulations than those who worked outside the city. Those categorized as builders indicated significantly more contract performance issues. Furthermore, a set of recommendations were highlighted to strengthen the industry’s response to future similar disruptions. This study is significant in helping researchers and businesses build more resilient operations to address current and future pandemic-related challenges facing the construction industry.
TT-M Finite Element Algorithm for the Coupled Schrödinger–Boussinesq Equations
Authors: Tian Jiale , Sun Ziyu , Liu Yang , Li Hong
Published: June 2022

In this article, the coupled Schrödinger–Boussinesq equations are solved numerically using the finite element method combined with the time two-mesh (TT-M) fast algorithm. The spatial direction is discretized by the standard Galerkin finite element method, the temporal direction is approximated by the TT-M Crank–Nicolson scheme, and then the numerical scheme of TT-M finite element (FE) system is formulated. The method includes three main steps: for the first step, the nonlinear system is solved on the coarse time mesh; for the second step, by an interpolation formula, the numerical solutions at the fine time mesh point are computed based on the numerical solutions on the coarse mesh system; for the last step, the linearized temporal fine mesh system is constructed based on Taylor’s formula for two variables, and then the TT-M FE solutions can be obtained. Furthermore, theory analyses on the TT-M system including the stability and error estimations are conducted. Finally, a large number of numerical examples are provided to verify the accuracy of the algorithm, the correctness of theoretical results, and the computational efficiency with a comparison to the numerical results calculated by using the standard FE method.
Refinements to Relation-Theoretic Contraction Principle
Authors: Alam Aftab , George Reny , Imdad Mohammad
Published: June 2022

After the appearance of relation-theoretic contraction principle proved in a metric space equipped with an amorphous binary relation (often termed as relational metric space), various core fixed point results have been proved in the setting of different relational distance spaces by varying underlying contraction conditions. In proving such results, the notions of completeness of ambient space, continuity of involved mapping and d-self-closedness of underlying binary relation are of paramount importance. The aim of this paper is to further refine the relation-theoretic contraction principle by relaxing the conditions of completeness and continuity by replacing their respective relation-theoretic analogues. Moreover, we observe that the notion of d-self-closedness utilized in relation-theoretic contraction principle is more general than the concepts of regularity and strong regularity utilized by earlier authors.
A Diet Supplemented with Polyphenols, Prebiotics and Omega-3 Fatty Acids Modulates the Intestinal Microbiota and Improves the Profile of Metabolites Linked with Anxiety in Dogs
Authors: Ephraim Eden , Brockman Jeffrey A. , Jewell Dennis E.
Published: June 2022

A nutrition-based approach was utilized to examine the effects of fish oil and a polyphenol blend (with or without tomato pomace) on the fecal microbiota and plasma/fecal metabolomes. Forty dogs, aged 5–14 years, were fed a washout food, then randomized to consume a control (fish oil and polyphenol blend without tomato pomace) or test (fish oil and polyphenol blend with tomato pomace) food, then the washout food, and crossed over to consume the test or control food; each for 30 days. Several metabolites differed when comparing consumption of the washout with either the control or test foods, but few changed significantly between the test and control foods. Plasma levels of 4-ethylphenyl sulfate (4-EPS), a metabolite associated with anxiety disorders, demonstrated the largest decrease between the washout food and the control/test foods. Plasma 4-EPS levels were also significantly lower after dogs ate the test food compared with the control food. Other plasma metabolites linked with anxiety disorders were decreased following consumption of the control/test foods. Significant increases in Blautia, Parabacteroides, and Odoribacter in the fecal microbiota correlated with decreases in 4-EPS when dogs ate the control/test foods. These data indicate that foods supplemented with polyphenols and omega-3 fatty acids can modulate the gut microbiota to improve the profile of anxiety-linked metabolites.
Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network
Authors: Ichim Gabriel , Gibert Benjamin , Adriouch Sahil , Brenner Catherine , Davoust Nathalie , Desagher Solange , Devos David , Dokudovskaya Svetlana , Dubrez Laurence , Estaquier Jérôme , Gillet Germain , Guénal Isabelle , Juin Philippe P. , Kroemer Guido , Legembre Patrick , Levayer Romain , Manon Stéphen , Mehlen Patrick , Meurette Olivier , Micheau Olivier , Mignotte Bernard , Nguyen-Khac Florence , Popgeorgiev Nikolay , Poyet Jean-Luc , Priault Muriel , Ricci Jean-Ehrland , Riquet Franck B. , Susin Santos A. , Suzanne Magali , Vacher Pierre , Walter Ludivine , Mollereau Bertrand
Published: June 2022

Since the Nobel Prize award more than twenty years ago for discovering the core apoptotic pathway in C. elegans, apoptosis and various other forms of regulated cell death have been thoroughly characterized by researchers around the world. Although many aspects of regulated cell death still remain to be elucidated in specific cell subtypes and disease conditions, many predicted that research into cell death was inexorably reaching a plateau. However, this was not the case since the last decade saw a multitude of cell death modalities being described, while harnessing their therapeutic potential reached clinical use in certain cases. In line with keeping research into cell death alive, francophone researchers from several institutions in France and Belgium established the French Cell Death Research Network (FCDRN). The research conducted by FCDRN is at the leading edge of emerging topics such as non-apoptotic functions of apoptotic effectors, paracrine effects of cell death, novel canonical and non-canonical mechanisms to induce apoptosis in cell death-resistant cancer cells or regulated forms of necrosis and the associated immunogenic response. Collectively, these various lines of research all emerged from the study of apoptosis and in the next few years will increase the mechanistic knowledge into regulated cell death and how to harness it for therapy.
Getting Closer to Decrypting the Phase Transitions of Bacterial Biomolecules
Authors: Sołtys Katarzyna , Tarczewska Aneta , Bystranowska Dominika , Sozańska Nikola
Published: June 2022

Liquid–liquid phase separation (LLPS) of biomolecules has emerged as a new paradigm in cell biology, and the process is one proposed mechanism for the formation of membraneless organelles (MLOs). Bacterial cells have only recently drawn strong interest in terms of studies on both liquid-to-liquid and liquid-to-solid phase transitions. It seems that these processes drive the formation of prokaryotic cellular condensates that resemble eukaryotic MLOs. In this review, we present an overview of the key microbial biomolecules that undergo LLPS, as well as the formation and organization of biomacromolecular condensates within the intracellular space. We also discuss the current challenges in investigating bacterial biomacromolecular condensates. Additionally, we highlight a summary of recent knowledge about the participation of bacterial biomolecules in a phase transition and provide some new in silico analyses that can be helpful for further investigations.
Resveratrol and ω-3 PUFAs Promote Human Macrophage Differentiation and Function
Authors: Schwager Joseph , Bompard Albine , Raederstorff Daniel , Hug Hubert , Bendik Igor
Published: June 2022

Monocytes differentiate into M1 and M2 macrophages, which are classically activated by microbial products such as LPS or IFN-γ and interleukins (e.g., the anti-inflammatory and Th2 promoting IL-4), respectively. The contribution of nutrients or nutrient-based substances such as ω-3 polyunsaturated fatty acids (ω-3 PUFAs) and resveratrol (Res) on the differentiation and function of M1 and M2 macrophages was evaluated. THP-1 cells and peripheral blood mononuclear cells (PBMCs) were differentiated into M1 and M2 cells and activated with LPS/IFN-γ or IL-4/IL-13. Macrophage lineage specific surface determinants (e.g., CD11b, CD11c, CD14, CD206, CD209, CD274, HLA-DR, CCR7, CCR2) were analysed by cytofluorometry. Res and ω-3 PUFAs altered CD14, CD206, CD274 and HL-DR surface expression patterns in M1 and M2 macrophages differentiated from PBMC. LPS/IFN-γ or IL-14/IL-13 activated macrophages subpopulations, which secreted cytokines and chemokines as measured by multiplex ELISA. Res and ω-3 PUFA reduced IL-1β, IL-6, TNF-α, CXCL10/IP-10, CCL13/MCP-4 and CCL20/MIP-3α in LPS/IFN-γ activated human leukaemia THP-1 cells, which is indicative of a dampening effect on M1 macrophages. However, Res increased M1 prototypic cytokines such as IL-1β or IL-6 in macrophages derived from PBMCs and also modified the expression of IL-12p70. Collectively, Res and ω-3 PUFAs distinctly promoted the differentiation and function of M1 and M2 macrophages. We conclude that these substances strengthen the macrophage-mediated effects on the innate and adaptive immune response.
Recent Developments and Future Perspective on Electrochemical Glucose Sensors Based on 2D Materials
Authors: Radhakrishnan Sithara , Lakshmy Seetha , Santhosh Shilpa , Kalarikkal Nandakumar , Chakraborty Brahmananda , Rout Chandra Sekhar
Published: June 2022

Diabetes is a health disorder that necessitates constant blood glucose monitoring. The industry is always interested in creating novel glucose sensor devices because of the great demand for low-cost, quick, and precise means of monitoring blood glucose levels. Electrochemical glucose sensors, among others, have been developed and are now frequently used in clinical research. Nonetheless, despite the substantial obstacles, these electrochemical glucose sensors face numerous challenges. Because of their excellent stability, vast surface area, and low cost, various types of 2D materials have been employed to produce enzymatic and nonenzymatic glucose sensing applications. This review article looks at both enzymatic and nonenzymatic glucose sensors made from 2D materials. On the other hand, we concentrated on discussing the complexities of many significant papers addressing the construction of sensors and the usage of prepared sensors so that readers might grasp the concepts underlying such devices and related detection strategies. We also discuss several tuning approaches for improving electrochemical glucose sensor performance, as well as current breakthroughs and future plans in wearable and flexible electrochemical glucose sensors based on 2D materials as well as photoelectrochemical sensors.
The Lateralization of Resting Motor Threshold to Predict Medication-Mediated Improvement in Parkinson’s Disease
Authors: Mano Tomoo , Kinugawa Kaoru , Fujimura Shigekazu , Sugie Kazuma
Published: June 2022

Cortical stimulation patterns in patients with Parkinson’s disease (PD) are asymmetric and get altered over time. This study examined cortical neurophysiological markers for PD and identified neurophysiological markers for lateralization in PD. We used transcranial magnetic stimulation (TMS) to study corticospinal and intracortical excitability in 21 patients with idiopathic PD. We used the Movement Disorder Society Unified Parkinson’s Disease Rating Scale for examination during on and off periods and evaluated inhibitory and facilitatory process markers using TMS, including resting motor thresholds (RMT), active motor thresholds, and motor evoked potential amplitude. The RMT in the more affected cortex was significantly shorter than in the less affected cortex, and was strongly correlated with improved motor function following medication. Patients in the tremor group exhibited significantly lower RMT compared to those in the akinetic-rigid group. Cortical electrophysiological laterality observed in patients with PD may be a useful marker for guiding treatment and identifying underlying compensatory mechanisms.
Compensated Integrated Gradients for Reliable Explanation of Electroencephalogram Signal Classification
Authors: Kawai Yuji , Tachikawa Kazuki , Park Jihoon , Asada Minoru
Published: June 2022

The integrated gradients (IG) method is widely used to evaluate the extent to which each input feature contributes to the classification using a deep learning model because it theoretically satisfies the desired properties to fairly attribute the contributions to the classification. However, this approach requires an appropriate baseline to do so. In this study, we propose a compensated IG method that does not require a baseline, which compensates the contributions calculated using the IG method at an arbitrary baseline by using an example of the Shapley sampling value. We prove that the proposed approach can compute the contributions to the classification results reliably if the processes of each input feature in a classifier are independent of one another and the parameterization of each process is identical, as in shared weights in convolutional neural networks. Using three datasets on electroencephalogram recordings, we experimentally demonstrate that the contributions obtained by the proposed compensated IG method are more reliable than those obtained using the original IG method and that its computational complexity is much lower than that of the Shapley sampling method.
Development and Validation of a Brief Scale of Vengeful Tendencies (BSVT-11) in a Mexican Sample
Authors: Flores-Camacho Ana Lorena , Castillo-Verdejo Diana Laura , Penagos-Corzo Julio C.
Published: June 2022

The development and analysis of psychometric properties of a brief scale that assesses vengeful tendencies (BSVT-11) is presented. A three-dimensional model is proposed: (1) resentment, (2) planning of revenge, and (3) justification of revenge. Two studies were conducted for this purpose: one was carried out with a sample of 478 participants, to evaluate the content validity, factorial structure, reliability, and invariance of the instrument; the other was conducted with a sample of 308 participants, to determine the concurrent validity of the BSVT-11. The data indicated adequate reliability (ω = 0.877), optimal fit (CFI = 1.0, TLI = 1.0) according to the dimensions proposed, and invariance between genders (p = 0.893). Concurrent validity data yield significant correlation values (p < 0.001) ranging from 0.522 to 0.804 in the analyses between the BSVT and other scales. The results allow us to present a brief instrument with good psychometric properties with possibilities for use in basic and translational science.
Prestressed Concrete Box Girder with High-Capacity Strands-Monitoring and Analysis during Fabrication
Authors: Jiang Xin , Ban Xinlin , Ma Lin , Su Yonghua , Cao Qi , Zhang Zhouyu , Guo Jichao
Published: June 2022

Despite the attractive merits of high-capacity strands, the application in bridge girders is limited due to concerns, including concrete cracking, excessive stress, and cambers. An efficient and defect-free production is the first step to wide application. The objective of this research was to alleviate the production concerns of prestressed concrete bridge girders using high-capacity strands. A gigantic prestressed concrete box girder using 18-mm strands was produced; its entire fabrication process (from strand stressing to detension) was introduced. Sixteen temperature gauges were embedded in the girder to monitor the hydration of the large volume of concrete and the adjacent environmental temperature. Moreover, displacement transducers were used to measure the camber at detension; load cells were installed to monitor the variations of the prestressing strand tensile forces during fabrication. Monitoring and analysis showed that the timing of the detension is determined by the hydration of the concrete, the compressive strength of the concrete, and its modulus of elasticity or age. Since the tensile forces in strands are affected by the concrete’s internal temperature, the detension is conducted after the concrete temperature falls back (close to its initial value); otherwise, unfavorable and considerable prestress losses are caused. Finally, a 4-d detension was suggested since the hydration was not a concern at the time; the predicted prestress loss and camber were acceptable and the concrete material properties at 4 d satisfied the requirements.
Economic Perspective of Cancer Care and Its Consequences for Vulnerable Groups
Authors: Haier Joerg , Schaefers Juergen
Published: June 2022

Within healthcare systems in all countries, vulnerable groups of patients can be identified and are characterized by the reduced utilization of available healthcare. Many different reasons can be attributed to this observation, summarized as implementation barriers involving acceptance, accessibility, affordability, acceptability and quality of care. For many patients, cancer care is specifically associated with the occurrence of vulnerability due to the complex disease, very different target groups and delivery situations (from prevention to palliative care) as well as cost-intensive care. Sociodemographic factors, such as educational level, rural/remote location and income, are known determinants for these vulnerable groups. However, different forms of financial burdens likely influence this vulnerability in cancer care delivery in a distinct manner. In a narrative review, these socioeconomic challenges are summarized regarding their occurrence and consequences to current cancer care. Overall, besides direct costs such as for treatment, many facets of indirect costs including survivorship costs for the cancer patients and their social environment need to be considered regarding the impact on vulnerability, treatment compliance and abundance. In addition, individual cancer-related financial burden might also affect the society due to the loss of productivity and workforce availability. Healthcare providers are requested to address this vulnerability during the treatment of cancer patients.
Dual PI3K/mTOR Inhibitor NVP-BEZ235 Leads to a Synergistic Enhancement of Cisplatin and Radiation in Both HPV-Negative and -Positive HNSCC Cell Lines
Authors: Subtil Florentine S. B. , Gröbner Carolin , Recknagel Niklas , Parplys Ann Christin , Kohl Sibylla , Arenz Andrea , Eberle Fabian , Dikomey Ekkehard , Engenhart-Cabillic Rita , Schötz Ulrike
Published: June 2022

The standard of care for advanced head and neck cancers (HNSCCs) is radiochemotherapy, including cisplatin. This treatment results in a cure rate of approximately 85% for oropharyngeal HPV-positive HNSCCs, in contrast to only 50% for HPV-negative HNSCCs, and is accompanied by severe side effects for both entities. Therefore, innovative treatment modalities are required, resulting in a better outcome for HPV-negative HNSCCs, and lowering the adverse effects for both entities. The effect of the dual PI3K/mTOR inhibitor NVP-BEZ235 on a combined treatment with cisplatin and radiation was studied in six HPV-negative and six HPV-positive HNSCC cell lines. Cisplatin alone was slightly more effective in HPV-positive cells. This could be attributed to a defect in homologous recombination, as demonstrated by depleting RAD51. Solely for HPV-positive cells, pretreatment with BEZ235 resulted in enhanced cisplatin sensitivity. For the combination of cisplatin and radiation, additive effects were observed. However, when pretreated with BEZ235, this combination changed into a synergistic interaction, with a slightly stronger enhancement for HPV-positive cells. This increase could be attributed to a diminished degree of DSB repair in G1, as visualized via the detection of γH2AX/53BP1 foci. BEZ235 can be used to enhance the effect of combined treatment with cisplatin and radiation in both HPV-negative and -positive HNSCCs.
Immunological Landscape of HER-2 Positive Breast Cancer
Authors: Moragon Santiago , Hernando Cristina , Martinez-Martinez Maria Teresa , Tapia Marta , Ortega-Morillo Belen , Lluch Ana , Bermejo Begoña , Cejalvo Juan Miguel
Published: June 2022

Understanding the biological aspects of immune response in HER2+ breast cancer is crucial to implementing new treatment strategies in these patients. It is well known that anti-HER2 therapy has improved survival in this population, yet a substantial percentage may relapse, creating a need within the scientific community to uncover resistance mechanisms and determine how to overcome them. This systematic review indicates the immunological mechanisms through which trastuzumab and other agents target cancer cells, also outlining the main trials studying immune checkpoint blockade. Finally, we report on anti-HER2 vaccines and include a figure exemplifying their mechanisms of action.
High Expression of PRNP Predicts Poor Prognosis in Korean Patients with Gastric Cancer
Authors: Choi Minseok , Moon SeongRyeol , Eom Hyo Jin , Lim Seung Mook , Kim Yon Hui , Nam Seungyoon
Published: June 2022

Gastric cancer (GC) has the highest occurrence and fourth-highest mortality rate of all cancers in Korea. Although survival rates are improving with the development of diagnosis and treatment methods, the five-year survival rate for stage 4 GC in Korea remains <10%. Therefore, it is important to identify candidate prognostic factors for predicting poor prognosis. PRNP is a gene encoding the prion protein PrP, which has been noted for its role in the nervous system and is known to be upregulated in various cancers and associated with both cell proliferation and metastasis. However, the value of PRNP as a prognostic factor for Korean GC patients remains unclear. Here, we analyzed the relationship between PRNP expression and survival in three independent datasets for Korean patients with GC as well as the TCGA-STAD dataset. Survival analysis indicates that high levels of PRNP expression are associated with poor overall survival of patients with GC. Gene set enrichment analysis showed that PRNP is associated with epithelial mesenchymal transition and Hedgehog signaling. In addition, proliferation of GC cell lines was inhibited after siRNA-mediated knockdown of PRNP. In conclusion, our study suggests a potential role for PRNP as a candidate prognostic factor for patients with GC.
Mucosal Plasma Cell Activation and Proximity to Nerve Fibres Are Associated with Glycocalyx Reduction in Diarrhoea-Predominant Irritable Bowel Syndrome: Jejunal Barrier Alterations Underlying Clinical Manifestations
Authors: Pardo-Camacho Cristina , Ganda Mall John-Peter , Martínez Cristina , Pigrau Marc , Expósito Elba , Albert-Bayo Mercé , Melón-Ardanaz Elisa , Nieto Adoración , Rodiño-Janeiro Bruno , Fortea Marina , Guagnozzi Danila , Rodriguez-Urrutia Amanda , Torres Inés de , Santos-Briones Ignacio , Azpiroz Fernando , Lobo Beatriz , Alonso-Cotoner Carmen , Santos Javier , González-Castro Ana M. , Vicario Maria
Published: June 2022

Irritable bowel syndrome (IBS) is a disorder of brain-gut interaction characterised by abdominal pain and changes in bowel habits. In the diarrhoea subtype (IBS-D), altered epithelial barrier and mucosal immune activation are associated with clinical manifestations. We aimed to further evaluate plasma cells and epithelial integrity to gain understanding of IBS-D pathophysiology. One mucosal jejunal biopsy and one stool sample were obtained from healthy controls and IBS-D patients. Gastrointestinal symptoms, stress, and depression scores were recorded. In the jejunal mucosa, RNAseq and gene set enrichment analyses were performed. A morphometric analysis by electron microscopy quantified plasma cell activation and proximity to enteric nerves and glycocalyx thickness. Immunoglobulins concentration was assessed in the stool. IBS-D patients showed differential expression of humoral pathways compared to controls. Activation and proximity of plasma cells to nerves and IgG concentration were also higher in IBS-D. Glycocalyx thickness was lower in IBS-D compared to controls, and this reduction correlated with plasma cell activation, proximity to nerves, and clinical symptoms. These results support humoral activity and loss of epithelial integrity as important contributors to gut dysfunction and clinical manifestations in IBS-D. Additional studies are needed to identify the triggers of these alterations to better define IBS-D pathophysiology.
Role of Th17 Cytokines in the Liver’s Immune Response during Fatal Yellow Fever: Triggering Cell Damage Mechanisms
Authors: Carvalho Marcos Luiz Gaia , Falcão Luiz Fábio Magno , Lopes Jeferson da Costa , Mendes Caio Cesar Henriques , Olímpio Fábio Alves , Miranda Vanessa do Socorro Cabral , Santos Lais Carneiro dos , de Moraes Daniel Dias Pinheiro de , Bertonsin Filho Marcos Virgilio Bertonsin , da Costa Luccas Delgado da , da Silva Azevedo Raimunda do Socorro da Silva , Cruz Ana Cecília Ribeiro , Galúcio Vanessa Costa Alves , Martins Lívia Caricio , Duarte Maria Irma Seixas , Martins Filho Arnaldo Jorge Martins , Sousa Jorge Rodrigues de , Vasconcelos Pedro Fernando da Costa , Quaresma Juarez Antônio Simões
Published: June 2022

Yellow fever (YF) is an infectious and acute viral haemorrhagic disease that triggers a cascade of host immune responses. We investigated the Th17 cytokine profile in the liver tissue of patients with fatal YF. Liver tissue samples were collected from 26 deceased patients, including 21 YF-positive and 5 flavivirus-negative patients, with preserved hepatic parenchyma architecture, who died of other causes. Histopathological and immunohistochemical analysis were performed on the liver samples to evaluate the Th17 profiles (ROR-γ, STAT3, IL-6, TGF-β, IL-17A, and IL-23). Substantial differences were found in the expression levels of these markers between the patients with fatal YF and controls. A predominant expression of Th17 cytokine markers was observed in the midzonal region of the YF cases, the most affected area in the liver acinus, compared with the controls. Histopathological changes in the hepatic parenchyma revealed cellular damage characterised mainly by the presence of inflammatory cell infiltrates, Councilman bodies (apoptotic cells), micro/macrovesicular steatosis, and lytic and coagulative necrosis. Hence, Th17 cytokines play a pivotal role in the immunopathogenesis of YF and contribute markedly to triggering cell damage in patients with fatal disease outcomes.
Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway Modulators, from Current Insights to Future Perspectives
Authors: Bravo Gary Álvarez , Cedeño René Robles , Casadevall Marc Puig , Ramió-Torrentà Lluís
Published: June 2022

Sphingosine-1-phosphate (S1P) and S1P receptors (S1PR) are bioactive lipid molecules that are ubiquitously expressed in the human body and play an important role in the immune system. S1P-S1PR signaling has been well characterized in immune trafficking and activation in both innate and adaptive immune systems. Despite this knowledge, the full scope in the pathogenesis of autoimmune disorders is not well characterized yet. From the discovery of fingolimod, the first S1P modulator, until siponimod, the new molecule recently approved for the treatment of secondary progressive multiple sclerosis (SPMS), there has been a great advance in understanding the S1P functions and their involvement in immune diseases, including multiple sclerosis (MS). Modulation on S1P is an interesting target for the treatment of various autoimmune disorders. Improved understanding of the mechanism of action of fingolimod has allowed the development of the more selective second-generation S1PR modulators. Subtype 1 of the S1PR (S1PR1) is expressed on the cell surface of lymphocytes, which are known to play a major role in MS pathogenesis. The understanding of S1PR1’s role facilitated the development of pharmacological strategies directed to this target, and theoretically reduced the safety concerns derived from the use of fingolimod. A great advance in the MS treatment was achieved in March 2019 when the Food and Drug Association (FDA) approved Siponimod, for both active secondary progressive MS and relapsing–remitting MS. Siponimod became the first oral disease modifying therapy (DMT) specifically approved for active forms of secondary progressive MS. Additionally, for the treatment of relapsing forms of MS, ozanimod was approved by FDA in March 2020. Currently, there are ongoing trials focused on other new-generation S1PR1 modulators. This review approaches the fundamental aspects of the sphingosine phosphate modulators and their main similarities and differences.
Corrosion Behaviour of Nodular Cast Iron Used for Rotor Manufacturing in Different Wastewaters
Authors: Nejneru Carmen , Burduhos-Nergis Diana-Petronela , Axinte Mihai , Perju Manuela Cristina , Bejinariu Costica
Published: June 2022

Submersible drainage sump pumps work in a highly corrosive environment, forming films with corrosive reaction products on the surface. Pump rotors are high-demand parts, so they are made of quality materials with good wear and corrosion resistance properties such as nodular graphite cast iron. This paper analyses the corrosion behaviour of cast iron used in the manufacture of rotors in three types of wastewaters, with variable pH. Nodular graphite cast iron samples were immersed in wastewater for 30, 60, and 90 days and tested by linear polarisation and electrochemical impedance spectroscopy (EIS). Also, the layers of reaction products formed on the surface of the material were analysed by SEM and EDS. The results showed that nodular cast-iron immersed in wastewater with acidic pH showed intense corrosion, the oxide layer formed on its surface is unstable. Also, the final structure of the product layer is that of a tri-layer with cations and anions absorbed from the corrosion media: the double-electric layer directly connected to the metal surface, an internal layer consisting of ferrous compounds and ferric compounds that control the diffusion of oxygen, an outer layer, and a compact crust of ferric compounds. The change in the pH of the wastewater has a major influence on the corrosion rate of the cast iron, which increases from 356.4 µm/year in DWW-1 (6.5 pH) to 1440 µm/year in DWW-2 (3 pH) and 1743 µm/year DWWW-3 (11 pH) respectively. As can be seen, the experimental study covers the problem of the corrosion behaviour of the pump rotor in various types of wastewaters this aspect is particularly important for the good use of wastewater pumps and to predict possible deviations for the operation of the equipment within the treatment plants.
Coatings 2021 Outstanding Reviewer Award: Announcement and Interview with the Winner Dr. Valentina Marascu
Authors:   Coatings Editorial Office
Published: June 2022

The Coatings Editorial Board and Editorial Team would like to acknowledge the time and energy dedicated by the reviewers of manuscripts submitted to Coatings [...]