bluuebunny/crossref_metadata_2025 huggingface dataset:
A place of understanding: Patients' lived experiences of participating in a sexual rehabilitation programme after heart disease
Authors: Palm Pernille , Missel Malene , Zwisler Ann‐Dorthe , Svendsen Jesper Hastrup , Giraldi Annamaria , Berg Selina Kikkenborg
Published: July 2019

Aims and objectives

The aim of this project was to explore the lived experience of participating in a nonpharmacological sexual rehabilitation programme.

Background

In the healthcare system, patients are important stakeholders, and their experience and knowledge are essential to include when evaluating rehabilitation programmes. Patient experiences with participating in sexual rehabilitation for cardiovascular patients have not yet been investigated.

Methods

Ten qualitative interviews were conducted with male patients from a randomised controlled trial investigating the effect of a 12‐week rehabilitation programme focusing on sexuality. The analysis was inspired by Paul Ricoeur's theory of interpretation. Analysis consisted of three levels: (i) naive reading, (ii) structural analysis and (iii) critical interpretation and discussion. The theoretical framework reflects aspects of behavioural theory of social cognitive theory developed by Albert Bandura and his concept of self‐efficacy.

Results

The findings are presented as themes extracted from the structural analysis and interpreted in the critical interpretation and express the way in which cardiovascular patients experience participating in a sexual rehabilitation programme. Three themes were identified reflecting the intervention to be a special place of understanding, describing the intervention as a supporting atmosphere and finally expressing the intervention as empowering sexuality.

Conclusions

Participating in the sexual rehabilitation programme was experienced as efficient, valuable, motivating and safe, but dependent on a professional setting. The intervention developed participants' self‐efficacy with regard to their sexual performance and relationship.

Relevance to clinical practice

The findings highlight the importance of a professional setting including certain competencies such as humour and professional skills when handling the after‐care of cardiovascular patients with sexual problems.
The Intonation of the Left Periphery: A Matter of Pragmatics or Syntax?
Authors: Sequeros‐Valle Jose
Published: July 2019

This article investigates the intonation of the left periphery and its relationship with discourse and syntax. While some authors hypothesize that intonational patterns align with discourse functions (Bianchi & Frascarelli 2010, Frascarelli & Hinterhölzl 2007), others argue that intonational patterns are correlated with different types of constructions (Feldhausen 2016). In order to solve whether discourse or syntax predicts intonation in the left periphery, 12 participants completed a scripted production task. Two syntactic constructions, focus fronting and clitic‐doubled left dislocation, and two discourse functions, contrast and familiarity, were combined into three conditions: (i) contrastive–focus fronting, (ii) contrastive–clitic‐doubled left dislocation, and (iii) familiar–clitic‐doubled left dislocation. Results show that the overall intonational pattern of the left periphery aligns to construction type, with focus fronting presenting one nuclear configuration (L+H* L‐ no‐pause) and clitic‐doubled left dislocation presenting a different one (L+H* !H no‐pause). These findings are consistent with the construction‐based hypothesis and challenge the discourse‐based hypothesis.
Conformational regulation of AP1 and AP2 clathrin adaptor complexes
Authors: Beacham Gwendolyn M. , Partlow Edward A. , Hollopeter Gunther
Published: July 2019

Heterotetrameric clathrin adaptor protein complexes (APs) orchestrate the formation of coated vesicles for transport among organelles of the cell periphery. AP1 binds membranes enriched for phosphatidylinositol 4‐phosphate, such as the trans Golgi network, while AP2 associates with phosphatidylinositol 4,5‐bisphosphate of the plasma membrane. At their respective membranes, AP1 and AP2 bind the cytoplasmic tails of transmembrane protein cargo and clathrin triskelions, thereby coupling cargo recruitment to coat polymerization. Structural, biochemical and genetic studies have revealed that APs undergo conformational rearrangements and reversible phosphorylation to cycle between different activity states. While membrane, cargo and clathrin have been demonstrated to promote AP activation, growing evidence supports that membrane‐associated proteins such as Arf1 and FCHo also stimulate this transition. APs may be returned to the inactive state via a regulated process involving phosphorylation and a protein called NECAP. Finally, because antiviral mechanisms often rely on appropriate trafficking of membrane proteins, viruses have evolved novel strategies to evade host defenses by influencing the conformation of APs. This review will cover recent advances in our understanding of the molecular inputs that stimulate AP1 and AP2 to adopt structurally and functionally distinct configurations.
Evaluation of four techniques for injection of the proximal interphalangeal joint in horses
Authors: Mereu Matteo , Hawkes Claire , Cuddy Laura C. , Perez Olmos Juan F. , Pazzola Michele , McNally Turlough P.
Published: July 2019

Objective

To describe a dorsoproximal midline (DPM) standing technique for proximal interphalangeal joint (PIPJ) injection and to compare it to established dorsolateral flexed (DLF), palmaroproximal (PP), and dorsolateral standing (DLS) techniques.

Study design

Ex vivo study.

Sample population

Sixty cadaver equine thoracic limbs.

Methods

Limbs were divided into four groups (n = 15 each group), DLF, DPM, PP, and DLS. For each technique, three operators injected radiopaque contrast and methylene blue into the PIPJ in five limbs. The number of attempts required was recorded. Successful injection was confirmed by radiographic presence of contrast media within the PIPJ. Iatrogenic cartilage damage was assessed by gross examination. Statistical analysis was performed by Wilcoxon signed‐rank test (P < .05).

Results

The overall success rates were 86.6% to 93.3%. Although there was no difference in success rate, the frequency of needle repositioning was influenced by injection technique (P = .009). Dorsolateral standing had the highest mean ± SD value of attempts required to insert the needle in the joint space (2.62 ± 1.94). Injection technique influenced cartilage damage (P = .025), with the highest frequency recorded for DLS.

Conclusion

All four techniques for injecting the PIPJ were highly successful; DLS was associated with the highest number of needle repositionings and the highest incidence of iatrogenic injury to cartilage.

Clinical significance

Dorsolateral flexed should be considered as an alternative to the DLS technique to reduce iatrogenic cartilage injury when injecting the PIPJ. Dorsoproximal midline and DLF techniques have success rates comparable to traditional techniques, with lower incidence of iatrogenic cartilage damage in cadaver limbs.
Prevalence of enteric non‐typhoidal Salmonella in humans in the Middle East and North Africa: A systematic review and meta‐analysis
Authors: Al‐Rifai Rami H. , Chaabna Karima , Denagamage Thomas , Alali Walid Q.
Published: July 2019

To enhance efforts related to controlling foodborne pathogens in the Middle East and North Africa (MENA), information on epidemiology of non‐typhoidal Salmonella enterica (hereafter termed “Salmonella”) is limited. We quantified the overall regional and country‐specific Salmonella prevalence in different human populations and identified the most common serotypes. Published literature of Salmonella prevalence was systematically reviewed and reported following the Preferred Items for Systematic Reviews and Meta‐Analysis (PRISMA) guidelines. Pooled Salmonella prevalence measures were estimated using a random‐effects model. We identified 46 research reports that reported 84 Salmonella prevalence measures in 15 out of 24 countries in MENA. There were 252,831 tested humans with 6,356 Salmonella‐positive cases. The pooled Salmonella prevalence in MENA was estimated at 6.6% (95% confidence interval (CI): 5.4%–7.9%). The highest pooled Salmonella prevalence measures were in Morocco (17.9%, 95% CI: 5.7%–34.8%, 1997–2012), Tunisia (10.2%, 95% CI: 4.3%–18.0%, 1988–2009) and Sudan (9.2%, 95% CI: 6.5%–12.2%, 2006–2008), while the lowest were in Jordan (1.1%, 95% CI: 0.1%–3.0%, 1993–2010), Oman (1.2%, 95% CI: 1.2%–1.3%, 1998–2002) and Palestine (1.2%, 95% CI: 0.4%–2.1%, 1999–2011). In MENA, Salmonella pooled prevalence in gastrointestinal symptomatic, gastrointestinal asymptomatic and food handlers population groups was 13.0% (95% CI: 7.6%–19.6%), 11.4% (95% CI: 2.2%–25.7%) and 3.8% (95% CI: 1.0%–8.0%), respectively. Salmonella prevalence was 14.5% (95% CI: 8.7%–26.1%) in studies tested <100 subjects, whereas 4.6% (95% CI: 3.6%–5.8%) in studies tested ≥100 subjects. Salmonella Enteritidis (29.8%) and Typhimurium (23.6%) were the most common serotypes. Salmonella was a common foodborne pathogen in MENA countries, particularly in North African countries. Findings inform the scientific community, the public and the decision‐makers with Salmonella prevalence and gaps in evidence in MENA to support control and prevention strategies and could leverage more research studies.
Oral health outcomes for people with cerebral palsy: a scoping review protocol
Authors: Lansdown Karen , Smithers-Sheedy Hayley , Mathieu Coulton Kimberly , Irving Michelle
Published: July 2019

Objective:

This review aims to systematically map the literature reporting on oral health outcomes experienced by people with cerebral palsy.

Introduction:

At present, there are no documented systematic reviews reporting on oral health outcomes for people of all ages with cerebral palsy. Subsequently, there are no clear guidelines, frameworks or detailed oral health recommendations for people with cerebral palsy. Considering the importance of oral health on general well-being and quality of life, it is important that it is not overlooked when focusing on patient-centered care for people with cerebral palsy.

Inclusion criteria:

Studies that focus on oral health, including dental diagnosis, trauma and/or treatment, facial pain, saliva, and sleep apnea, and/or make statements regarding oral health pertaining to cerebral palsy will be considered for inclusion inthis scoping review.

Methods:

This review will be conducted in accordance with the guidelines outlined by JBI methodology for scoping reviews and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR). Articles published in any language will be considered for inclusion, with no restriction on publication date. The search databases will include the Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, Scopus, Embase and Dentistry and Oral Science. A search of gray literature will also be conducted. Extracted data relevant to the scoping review will be performed by two reviewers.
De la respuesta correcta a la respuesta más justa. La intensidad de la tesis de la respuesta justa en las distintas etapas de la decisión judicial
Authors: Etcheverry Juan Bautista
Published: July 2019

Si bien hoy es mayoritariamente aceptado que los sistemas jurídicos resultan incapaces de ofrecer para todo caso una única respuesta correcta, todavía es posible (como hacen algunos autores) distinguir entre el plano de la corrección de una decisión jurídica de aquel de su justicia y defender que el derecho sí resultaría capaz de ofrecer un único resultado justo para todo caso. Por más que consideramos aceptable la distinción entre el plano de la corrección y el de la justicia, con este trabajo se busca mostrar que los tres principales argumentos para defender que para todo caso hay una única respuesta justa (argumento del máximo grado de concreción, de la bivalencia jurídica y de los principios ) no resultan capaces de lograr su objetivo. Sin embargo, advertiremos que estos argumentos sí son capaces de mostrar que el derecho consigue con diferente intensidad acotar los márgenes de decisión judicial según en qué etapa de esa decisión nos encontremos. Dejo estos principios en el mismo orden en que aparecen abajo: Los principales argumentos para defender la “tesis de la respuesta más justa” son tres: i) el argumento de que el máximo grado de concreción en el que se resuelven los casos exige una única respuesta; ii) el argumento de que la práctica jurídica simplifica la aplicación del derecho y la presenta como bivalente; y iii) el argumento de los principios, según el cual de las múltiples posibilidades interpretativas de una norma para resolver un caso en concreto, ha de decidirse por aquella que mejor realiza el conjunto de principios que justifican al derecho en general y a la decisión que se ha de tomar.
Notas sobre el derecho humano a la familia como derecho motor para el ejercicio de otros derechos humanos
Authors: Uribe Arzate Enrique , Bustamante Medrano Martha Guadalupe
Published: July 2019

Actualmente, los derechos humanos enfrentan un difícil proceso de aproximación a su disfrute efectivo. En la doctrina y en la legislación, hay un notable desarrollo declarativo sobre los derechos humanos. Sin embargo, el gran problema tiene lugar cuando las personas intentan ejercerlos y disfrutarlos, porque no hay condiciones óptimas para esto.

Algunos de los derechos humanos “más esenciales” pueden volverse realidad, si los ubicamos en el contexto del derecho humano a la familia, que como nuevo derecho humano, tiene la capacidad para servir como derecho motor para el ejercicio de otros derechos humanos que no tienen mejor escenario para su disfrute que la familia.
Reflexiones sobre la naturaleza del derecho urbanístico y propuesta de definición
Authors: Arbouin Gómez Felipe
Published: July 2019

A partir de la expedición de la Ley 9 de 1989, en el ordenamiento jurídico colombiano se afianzó una novedosa disciplina jurídica denominada derecho urbanístico, la cual ha sido presentada desde entonces desde diversas ópticas, ya sea como un conjunto de relaciones público-privadas, como parte general del derecho público, como una disciplina especial del Derecho Administrativo e incluso, como una nueva disciplina jurídica. Este artículo presenta una serie de reflexiones sobre la naturaleza, objetivos, principios y aplicación del derecho urbanístico y su ubicación dentro de las ciencias jurídicas, y culmina con la presentación de una propuesta de definición acorde con las materias estudiadas.
Validation of Notch Sensitivity Factors
Authors: Szabó Barna , Actis Ricardo , Rusk David
Published: July 2019

An end-to-end example of the application of the procedures of verification, validation, and uncertainty quantification (VVUQ) is presented with reference to mathematical models formulated for the prediction of fatigue failure in the high cycle range. A validation metric based on the log likelihood function is defined. It is shown that the functional forms of the notch sensitivity factors proposed by Neuber and Peterson cannot be validated but a revised form can be. Calibration and validation are based on published records of fatigue tests performed on notch-free and notched test coupons fabricated from aluminum alloy and alloy steel sheets.
Pseudo Credal Networks for Inference With Probability Intervals
Authors: Estrada-Lugo Hector Diego , Tolo Silvia , de Angelis Marco , Patelli Edoardo
Published: July 2019

The computation of the inference corresponds to an NP-hard problem even for a single connected credal network. The novel concept of pseudo networks is proposed as an alternative to reduce the computational cost of probabilistic inference in credal networks and overcome the computational cost of existing methods. The method allows identifying the combination of intervals that optimizes the probability values of each state of the queried variable from the credal network. In the case of no evidence, the exact probability bounds of the query variable are calculated. When new evidence is inserted into the network, the outer and inner approximations of the query variable are computed by means of the marginalization of the joint probability distributions of the pseudo networks. The applicability of the proposed methodology is shown by solving numerical case studies.
Comparison of Two-Dimensional and Three-Dimensional Carbon Electrode Geometries Affecting Bidirectional Electroosmotic Pumping
Authors: Vázquez-Piñón Matías , Hwang Hyundoo , Madou Marc J. , Kulinsky Lawrence , Martínez-Chapa Sergio O.
Published: July 2019

This study compares fluid velocity magnitude and direction for three different glassy carbon (GC) electrode systems effecting alternating current (AC) electroosmotic pumping. The flow behavior is analyzed for electroosmotic pumping performed with asymmetric coplanar electrodes. Subsequently, effects of adding microposts array of two different heights (40 μm and 80 μm) are studied. Experimental results demonstrate that as peak-to-peak voltage is increased above 10 V peak-to-peak, the flow reversal is achieved for planar electrodes. Utilization of microposts-enhanced asymmetric electrodes blocks the flow reversal and alters the magnitude of the fluid velocity at the application of larger voltages (above 10 V peak-to-peak). Understanding of the consequences of three-dimensional geometry of asymmetric electrodes would allow designing the electrode system for AC electroosmotic pumping and mixing, as well as bidirectional fluid driving with equal forward and backward flow velocities.
Oxygen reduction reaction mechanism of N-doped graphene nanoribbons
Authors: Matsuyama Haruyuki , Gomi Shun-ichi , Nakamura Jun
Published: July 2019

The oxygen reduction reaction (ORR) activity for the N-doped graphene nanoribbons with armchair (N-ACGNRs) and zigzag (N-ZZGNRs) edges has been investigated using first-principles calculations within the density functional theory. The values of the maximum electrode potential (UMax) for each doping site and reaction site of N-ACGNRs and N-ZZGNRs have been calculated. The selectivity for ORR with respect to two pathways, the direct four-electron (4e−) and the two-electron (2e−) pathways, has also been examined. The UMax for N-ZZGNR has a parity dependence with regard to the nitrogen doping site in the vicinity of the zigzag edge: For the even-numbered doping sites from the edge, the values of UMax are larger than 0 V, while for the odd-numbered ones, those become negative. On the other hand, the UMax for N-ACGNR becomes positive for each doping and reaction site. The reaction selectivity for the 4e− pathway appears only in the vicinity of the edges for N-ACGNRs and N-ZZGNRs, because the reaction intermediates adsorb stably on the edge C or π*-localized C atom adjacent to the doped N atom.
LKB1 specifies neural crest cell fates through pyruvate-alanine cycling
Authors: Radu Anca G. , Torch Sakina , Fauvelle Florence , Pernet-Gallay Karin , Lucas Anthony , Blervaque Renaud , Delmas Véronique , Schlattner Uwe , Lafanechère Laurence , Hainaut Pierre , Tricaud Nicolas , Pingault Véronique , Bondurand Nadège , Bardeesy Nabeel , Larue Lionel , Thibert Chantal , Billaud Marc
Published: July 2019

Glial specification of neural crest cells requires the tumor suppressor LKB1-mediated action on alanine biosynthesis.
Expanding the Soy Moratorium to Brazil’s Cerrado
Authors: Soterroni Aline C. , Ramos Fernando M. , Mosnier Aline , Fargione Joseph , Andrade Pedro R. , Baumgarten Leandro , Pirker Johannes , Obersteiner Michael , Kraxner Florian , Câmara Gilberto , Carvalho Alexandre X. Y. , Polasky Stephen
Published: July 2019

Expanding the Soy Moratorium to the Cerrado biome would prevent the direct conversion of 3.6 million ha of intact Cerrado to soy.
The regulatory B cell–mediated peripheral tolerance maintained by mast cell IL-5 suppresses oxazolone-induced contact hypersensitivity
Authors: Kim Hyuk Soon , Lee Min Bum , Lee Dajeong , Min Keun Young , Koo Jimo , Kim Hyun Woo , Park Young Hwan , Kim Su Jeong , Ikutani Masashi , Takaki Satoshi , Kim Young Mi , Choi Wahn Soo
Published: July 2019

Mast cells induce regulatory B cells to maintain peripheral tolerance in contact hypersensitivity.
Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss
Authors: Jiang Meiyan , Li Hongzhe , Johnson Anastasiya , Karasawa Takatoshi , Zhang Yuan , Meier William B. , Taghizadeh Farshid , Kachelmeier Allan , Steyger Peter S.
Published: July 2019

The nonselective cation channel TRPV1 is required for systemic inflammation to enhance aminoglycoside-induced hearing loss.
Worm tubes as conduits for the electrogenic microbial grid in marine sediments
Authors: Aller Robert C. , Aller Josephine Y. , Zhu Qingzhi , Heilbrun Christina , Klingensmith Isaac , Kaushik Aleya
Published: July 2019

Electron-conducting cable bacteria are found around worm tubes in bioturbated sediments in which they were thought to be rare.
Structural basis for the multitasking nature of the potato virus Y coat protein
Authors: Kežar Andreja , Kavčič Luka , Polák Martin , Nováček Jiří , Gutiérrez-Aguirre Ion , Žnidarič Magda Tušek , Coll Anna , Stare Katja , Gruden Kristina , Ravnikar Maja , Pahovnik David , Žagar Ema , Merzel Franci , Anderluh Gregor , Podobnik Marjetka
Published: July 2019

Structural and functional studies of the coat protein regions of potato virus Y reveal crucial roles in viral infectivity.
A new case of kleptoplasty in animals: Marine flatworms steal functional plastids from diatoms
Authors: Van Steenkiste Niels W. L. , Stephenson India , Herranz María , Husnik Filip , Keeling Patrick J. , Leander Brian S.
Published: July 2019

Experimental, transcriptomic, and ultrastructural data show that flatworms steal and retain functional plastids from diatoms.
Protein lysine de-2-hydroxyisobutyrylation by CobB in prokaryotes
Authors: Dong Hanyang , Zhai Guijin , Chen Cong , Bai Xue , Tian Shanshan , Hu Deqing , Fan Enguo , Zhang Kai
Published: July 2019

CobB serves as a lysine de-2-hydroxyisobutyrylation enzyme to regulate metabolism and cell growth in prokaryotes.
A defined antigen skin test for the diagnosis of bovine tuberculosis
Authors: Srinivasan Sreenidhi , Jones Gareth , Veerasami Maroudam , Steinbach Sabine , Holder Thomas , Zewude Aboma , Fromsa Abebe , Ameni Gobena , Easterling Laurel , Bakker Douwe , Juleff Nicholas , Gifford Glen , Hewinson R. G. , Vordermeier H. Martin , Kapur Vivek
Published: July 2019

A defined antigen skin test has been developed for the reliable diagnosis and vaccine-based control of bovine tuberculosis.
A neuro-inspired artificial peripheral nervous system for scalable electronic skins
Authors: Lee Wang Wei , Tan Yu Jun , Yao Haicheng , Li Si , See Hian Hian , Hon Matthew , Ng Kian Ann , Xiong Betty , Ho John S. , Tee Benjamin C. K.
Published: July 2019

A scalable communication architecture enables asynchronous readout of thousands of tactile sensors through a single conductor.
Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment
Authors: Zemek Rachael M. , De Jong Emma , Chin Wee Loong , Schuster Iona S. , Fear Vanessa S. , Casey Thomas H. , Forbes Cath , Dart Sarah J. , Leslie Connull , Zaitouny Ayham , Small Michael , Boon Louis , Forrest Alistair R. R. , Muiri Daithi O. , Degli-Esposti Mariapia A. , Millward Michael J. , Nowak Anna K. , Lassmann Timo , Bosco Anthony , Lake Richard A. , Lesterhuis W. Joost
Published: July 2019

A STAT1-driven inflammatory phenotype associated with response to checkpoint blocking antibodies sensitizes cancers to immunotherapy.
Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity
Authors: Marshall Emily E. , Malouli Daniel , Hansen Scott G. , Gilbride Roxanne M. , Hughes Colette M. , Ventura Abigail B. , Ainslie Emily , Selseth Andrea N. , Ford Julia C. , Burke David , Kreklywich Craig N. , Womack Jennie , Legasse Alfred W. , Axthelm Michael K. , Kahl Christoph , Streblow Daniel , Edlefsen Paul T. , Picker Louis J. , Früh Klaus
Published: July 2019

Live-attenuated, spread-deficient rhesus CMV vectors retain T cell immunogenicity.
Innate lymphoid cells pack on the pounds
Authors: Hickman Heather D.
Published: July 2019

Small intestine innate lymphoid cells induce diet-related obesity in mouse models.
A mitochondrial Pac-man drug to tackle aging
Authors: Yang Ming
Published: July 2019

Urolithin A, an activator of mitophagy, is safe to use and increases skeletal muscle mitochondrial gene expression in elderly individuals.
Evaluation of Fetal and Maternal Vancomycin-Induced Kidney Injury during Pregnancy in a Rat Model
Authors: Joshi Medha D. , Pais Gwendolyn M. , Chang Jack , Hlukhenka Khrystyna , Avedissian Sean N. , Gulati Anil , Prozialeck Walter C. , Lamar Peter C. , Zhang Zhong , Scheetz Marc H. , Griffin Brooke
Published: July 2019

Previous literature suggests that maternal vancomycin crosses the placental barrier to the fetus. Further, early animal studies indicated that kidney injury was not observed in the progeny. These studies were conducted prior to the availability of sensitive biomarkers for kidney injury. Therefore, a previous finding of no renal damage to the infant may be misleading.
T-BAS Version 2.1: Tree-Based Alignment Selector Toolkit for Evolutionary Placement of DNA Sequences and Viewing Alignments and Specimen Metadata on Curated and Custom Trees
Authors: Carbone Ignazio , White James B. , Miadlikowska Jolanta , Arnold A. Elizabeth , Miller Mark A. , Magain Nicolas , U'Ren Jana M. , Lutzoni François
Published: July 2019

The Tree-Based Alignment Selector (T-BAS) toolkit combines phylogenetic-based placement of DNA sequences with alignment and specimen metadata visualization tools in an integrative pipeline for analyzing microbial biodiversity. The release of T-BAS version 2.1 makes available reference phylogenies, supports multilocus sequence placements and permits uploading and downloading trees, alignments, and specimen metadata.
Draft Genome Sequence of
Desulfosporosinus
sp. Strain Sb-LF, Isolated from an Acidic Peatland in Germany
Authors: Hausmann Bela , Pjevac Petra , Huemer Martin , Herbold Craig W. , Pester Michael , Loy Alexander
Published: July 2019

Desulfosporosinus
sp. strain Sb-LF was isolated from an acidic peatland in Bavaria, Germany. Here, we report the draft genome sequence of the sulfate-reducing and lactate-utilizing strain Sb-LF.
Nearly Complete Genome Sequence of a Sapelovirus A Strain Identified in Swine in Italy
Authors: Tassoni L. , Zamperin G. , Monne I. , Beato M. S.
Published: July 2019

We report the first nearly complete genome sequence of a porcine sapelovirus (PSV) A strain that was identified from feces of piglets suffering from diarrhea in Italy in 2015. Phylogenetic investigations revealed a separate clustering for the Italian PSV, indicating unique molecular features.
Lyon-IARC Polyomavirus DNA in Feces of Diarrheic Cats
Authors: Fahsbender Elizabeth , Altan Eda , Estrada Marko , Seguin M. Alexis , Young Pauline , Leutenegger Christian M. , Delwart Eric
Published: July 2019

A viral metagenomic analysis of feces from an unexplained outbreak of feline diarrhea revealed the presence of Lyon-IARC polyomavirus (LIPyV) DNA. LIPyV, whose genome was originally sequenced from swabs of human skin, was fecally shed by three out of five diarrheic cats.
Draft Genome Sequences of Six Flavobacterium psychrophilum Strains Isolated from Dead Juvenile Ayu (Plecoglossus altivelisaltivelis) near the Mouth of the Nahari River, Kochi, Japan
Authors: Yamashita Hazuki , Wada Takayuki , Kato Yusuke , Ikeda Takuji , Imajoh Masayuki
Published: July 2019

Flavobacterium psychrophilum
causes bacterial cold-water disease in ayu inhabiting clear rivers in Japan. In this study, we report the draft genome sequences of six
F. psychrophilum
strains isolated from the gills and skin of dead juvenile ayu near the mouth of the Nahari River.
Complete Genome Sequence of Staphylococcus aureus Siphophage Sebago
Authors: Klotz Kathryn , Korn Abby , Newkirk Heather , Liu Mei , Gill Jason J. , Ramsey Jolene
Published: July 2019

Here, we introduce the genome of Sebago, a 43,878-bp siphophage that infects
Staphylococcus aureus
. Sebago carries 70 proteins and is most closely related to StauST398, a
Phietavirus
.
Complete Genome Sequence of
Luteibacter pinisoli
MAH-14
Authors: Baltrus David A. , Clark Meara , Inderbitzin Patrik , Pignatta Daniela , Knight-Connoni Victoria , Arnold A. Elizabeth
Published: July 2019

Diverse strains of
Luteibacter
(
Gammaproteobacteria
) have been isolated from a variety of environments, most frequently in association with both plants and fungi. Motivated by the lack of genomic information for strains throughout the genus
Luteibacter,
we report here a complete genome sequence for
Luteibacter pinisoli
strain MAH-14.
New geochronologic and paleomagnetic results from early Neoproterozoic mafic sills and late Mesoproterozoic to early Neoproterozoic successions in the eastern North China Craton, and implications for the reconstruction of Rodinia
Authors: Zhao Hanqing , Zhang Shihong , Ding Jikai , Chang Linxi , Ren Qiang , Li Haiyan , Yang Tianshui , Wu Huaichun
Published: July 2019

The interval from the late Mesoproterozoic to early Neoproterozoic is generally considered as a critical time for the amalgamation of Rodinia. The location of the North China Craton (NCC) in Rodinia remains contentious and demands greater paleomagnetic constraints. A combined geochronologic and paleomagnetic study was conducted on the late Mesoproterozoic to early Neoproterozoic rocks in the eastern NCC. Three sills were dated at ca. 945 Ma and one at ca. 920 Ma through use of the zircon U-Pb secondary ion mass spectroscopy method. Paleomagnetic investigation revealed no significant discrepancy between these sills. A positive baked-contact test, secular variation test and presence of reversals together support the primary origin interpretation for the remnant magnetization. A high-quality pole at (28.2 °S, 141.9 °E, A95 = 10.4°) was thus obtained by averaging our new results and a virtual geomagnetic pole previously reported for a ca. 920 Ma sill in the region. These Neoproterozoic sills intruded the successions that contain correlative strata that are named Nanfen, Xinxing, and Liulaobei formations in Liaoning, Jiangsu, and Anhui provinces, respectively. The Nanfen Formation and its equivalents are constrained between ca. 1120 and ca. 945 Ma by detrital zircons and the well-dated mafic sills. The paleomagnetic inclinations observed from the lower parts of the Nanfen, Xinxing, and Liulaobei formations are notably steep. The corresponding poles from these rock units are consistent and averaged at 38.6 °N, 136.7 °E (A95 = 3.2°). The quality of this pole is strengthened by a positive reversal test and its distinctiveness from the younger poles of the NCC. In the middle part of the Nanfen Formation, however, the paleomagnetic directions are characterized by moderate inclinations, being significantly different from those in the lower part of the Nanfen Formation and its equivalents. The calculated pole for the upper part of the Lower Member of the Nanfen Formation is at 8.0 °N, 128.5 °E (A95 = 7.9°). Another pole obtained from the Middle Member of the Nanfen Formation is at 11.2 °S, 127.7 °E (A95 = 8.5°). These two poles also differ from the younger poles of the NCC and likely represent the primary remanences. Our new results, together with the existing global paleomagnetic data and geological evidence, aided by the “right-way-up” connection model between Laurentia and Baltica in Rodinia, support a NCC–NW Laurentia connection between ca. 1120 and 890 Ma.
Posterior reversible encephalopathy syndrome as a complication of pre-eclampsia in the early postpartum period
Authors: Verhaegen Julie , Peeters Frederik , Debois Patrick , Jacquemyn Yves
Published: July 2019

We present the case of a 30-year-old woman with posterior reversible encephalopathy syndrome (PRES) as a complication of pre-eclampsia in the early postpartum period. PRES is a rare neurological disorder which causes non-specific neurological symptoms such as headache, seizures and visual disturbances. It generally has a good prognosis, but severe complications can arise. Therefore, early recognition and treatment are paramount. Pre-eclampsia is a multiorgan disease and is associated with both maternal and foetal morbidity and mortality. Neurological symptoms occurring in the postpartum period indicate pre-eclampsia until proven otherwise. This case report was written to stress the attention on this rare complication of pre-eclampsia. When a patient in the postpartum period presents with a combination of seizures, disturbed vision and headache, PRES should always be kept in mind.
Metastatic prostate cancer presenting as tumour-induced osteomalacia
Authors: Layman Awo Akosua K , Joshi Shivam , Shah Sanjeev
Published: July 2019

Tumour-induced osteomalacia (TIO), or oncogenic osteomalacia, is a paraneoplastic syndrome marked by hypophosphataemia, renal phosphate wasting, bone pain, weakness, and fractures. The syndrome has been reported with both benign and malignant tumours including parotid gland basal cell tumours, thyroid carcinomas, colon adenocarcinomas, and prostate cancer. Often, the syndrome is marked by an insidious course during which patients present with generalised bony pain and weakness, which do not resolve until the underlying tumour is identified and treated. We present a case of a patient with Parkinson’s disease whose subacute weakness, lower extremity paresis, and renal phosphate wasting led to the synchronous diagnosis of metastatic prostate adenocarcinoma and TIO.
Use of complementary medicine products: a nationally representative cross-sectional survey of 2019 Australian adults
Authors: Harnett Joanna E , McIntyre Erica , Steel Amie , Foley Hope , Sibbritt David , Adams Jon
Published: July 2019

Objectives

To provide a contemporary description of complementary medicine (CM) product use in Australia.

Design

Cross-sectional survey.

Setting

Online.

Participants

A nationally representative sample (n=2019) of the Australian adult population.

Primary and secondary outcome measures

Primary outcomes measures included the use and type of CM products used, and source of recommendation. Secondary measures included disclosure of CM product use to health practitioners, concomitant use of pharmaceuticals and predictors of use.

Results

Prevalence of CM product use was 50.3%, with the most frequently used being vitamin and mineral supplements (VMSs; 47.8%) and homoeopathic medicines the least used (6.8%). A majority of respondents using CM products were also using pharmaceutical products, and small but significant associations were found between the use of CM products and pharmaceuticals (p<0.05). Small statistically significant associations were found between use of vitamin products and disclosure of use to general practitioners (GPs; Cramer’s V=0.13, p=0.004) and hospital doctors (Cramer’s V=0.11, p=0.04), and between use of herbal medicines and disclosure to both GPs (Cramer’s V=0.11, p=0.02) and hospital doctors (Cramer’s V=0.12, p=0.03). Women, those with higher education and those with no private health insurance were more likely to use CM products (p<0.05), while those without chronic conditions were less likely to use CM products (p<0.05) (χ2(29)=174.70, p<0.001).

Conclusions

The number of Australians using CM products has remained relatively stable and substantial for nearly two decades. The majority of CM use relates to VMSs. Given the number of Australians using both CM products and pharmaceutical medicines, it is important to evaluate the potential clinical implications of such practices to ensure safe, effective and coordinated health policy and patient care.
Spatial and demographic disparities in short stature among school children aged 7–18 years: a nation-wide survey in China, 2014
Authors: Ma Jia , Pei Tao , Dong Fen , Dong Yanhui , Yang Zhaogeng , Chen Jie , Guo Sihui , Zhao Qiuling , Wang Shunan , Ma Jun , Zhang Zhixin
Published: July 2019

Objectives

To identify spatial disparities and demographic characteristics of short stature, we analysed the prevalence of short stature collected in a nationwide health survey.

Settings

Data were obtained from the 2014 Chinese National Survey on Students Constitution and Health (a cross-sectional study of China). Participants came from 30 provinces, autonomous regions, and municipalities (except Tibet, Hong Kong, Macao, and Taiwan).

Participants

There were 213 795 Han school children between 7 and 18 years old enrolled in our study. All participants were sampled by stratified cluster.

Primary and secondary outcome measures

Short stature; Chinese and WHO age-specific and gender-specific height growth references were used for short stature assessment.

Results

The age-standardised and age–gender-standardised prevalence of short stature nationwide was 3.70% and 2.69% according to Chinese and WHO growth references, respectively. The short stature prevalence differed significantly among age groups, urban and rural areas, and regions with different socioeconomic development levels (all p<0.0001). The prevalence was 2.23% in urban versus 5.12% in rural areas (p<0.001). The prevalence was 2.60% in developed, 3.72% in intermediately developed, and 4.69% in underdeveloped regions (p<0.0001). These values were all according to China’s growth reference, but similar patterns were observed on prevalence based on the WHO reference. The spatial distribution of prevalence of short stature presented a clustered pattern. Moran’s I value was 0.474 (p<0.001) and 0.478 (p<0.001) according to the Chinese and WHO growth references, respectively. The southwest part of China showed a higher prevalence of short stature, whereas lower prevalence of short stature was observed mainly in the northeast part of China.

Conclusions

There is an appreciably high prevalence of short stature in rural, underdeveloped areas of China. There are high prevalence spatial clusters of short stature in southwestern China. This provides corroborating evidence for a tailored strategy on short stature prevention and reduction in special areas.
Delineating the concept of self-management in chronic conditions: a concept analysis
Authors: Van de Velde Dominique , De Zutter Freya , Satink Ton , Costa Ursula , Janquart Sara , Senn Daniela , De Vriendt Patricia
Published: July 2019

Objectives

Self-management is a concept frequently used within healthcare but lacks consensus. It is the aim of this study to clarify the concept.

Design

Concept analysis according to Walker and Avant, comprises eight steps: select concept, determine purpose, identify uses, determine defining attributes, identify model case, identify additional cases, identify antecedents and consequences and define empirical referents. Sources used: PubMed, Scopus and Web of Science.

Results

Ten attributes delineating the concept have been identified and organised into three groups. Group (a): person-oriented attributes: the person must (1) actively take part in the care process, (2) take responsibility for the care process and (3) have a positive way of coping with adversity. Group (b): person-environment-oriented attributes: (4) the person must be informed about the condition, disease and treatment and self-management, (5) should be individualised, which entails expressing needs, values and priorities, (6) requires openness to ensure a reciprocal partnership with healthcare providers and (7) demands openness to social support. Finally, Group (c): summarising attributes: self-management (8) is a lifetime task, (9) assumes personal skills and (10) encompasses the medical, role and emotional management.

Conclusions

The findings of this study recognise the complexity of the concept, but also show the need for further investigation to make the concept more measurable. Clarity about the concept will enhance understanding and facilitate implementation in self-management programmes for chronic conditions.
Impact of military service on physical health later in life: a qualitative study of geriatric UK veterans and non-veterans
Authors: Williamson Victoria , Harwood Hannah , Greenberg Karla , Stevelink Sharon A M , Greenberg N
Published: July 2019

Objectives

Military veterans often experience physical health problems in later life; however, it remains unclear whether these problems are due to military service or are a feature of the ageing process. This study aimed to explore veteran and non-veteran perceptions of the impact of their occupation on their physical well-being later in life.

Design

Semi-structured qualitative interviews analysed using thematic analysis.

Setting

Interviews were conducted face-to-face in participants’ homes or via telephone.

Participants

35 veterans (≥65 years), 25 non-veterans (≥65 years) were recruited, as well as a close companion of all participants for triangulation (n=60).

Results

Most veterans reported good physical health later in life which they attributed to the fitness they developed during military service. However, several veterans described challenges in maintaining their desired level of physically activity due to new commitments and limited sports facilities when they left service. Fewer non-veterans had experienced work-related fitness activities or exercise in their civilian jobs. Ongoing physical health difficulties, such as deafness, were perceived to be due to exposure to workplace hazards and appeared more common in veterans compared with non-veterans. Veterans also described greater reluctance than non-veterans to seek medical treatment for physical health difficulties, which could be challenging for close companions who had to provide informal care.

Conclusions

Military service was largely perceived to be beneficial for physical well-being; although when occupation-related physical health problems were experienced, many veterans were unwilling to seek treatment. These findings may inform clinicians of the needs of older veterans and highlight potential barriers to care.
Reporting quality of randomised controlled trial abstracts presented at the SLEEP Annual Meetings: a cross-sectional study
Authors: Hua Fang , Sun Qiao , Zhao Tingting , Chen Xiong , He Hong
Published: July 2019

Objectives

To evaluate the reporting quality of randomised controlled trial (RCT) abstracts presented at a leading international conference in sleep medicine (the SLEEP Annual Meeting), and to investigate the association between potential predictors and the reporting quality of trial abstracts in this field.

Design

Cross-sectional, research on research study.

Methods

A handsearch of the 2016–2018 SLEEP Annual Meeting abstract books was carried out to identify abstracts describing RCTs. Quality of reporting was assessed with the original 17-item CONSORT for Abstracts checklist. Univariable and multivariable linear regression analyses were performed to identify significant predictors of reporting quality. In addition, risk ratios were used to analyse the adequate reporting rate of each quality item by type of intervention and funding status.

Primary and secondary outcome measures

The overall quality score (OQS, range 0–17) in accordance with the CONSORT for Abstracts checklist (primary outcome), and the adequate reporting rate of each checklist item (secondary outcome).

Results

A total of 176 RCT abstracts were included and assessed. The mean OQS was 5.53 (95% CI 5.30 to 5.76). Only three quality items (objective,conclusionsandfunding) were adequately reported in most abstracts (>75%). None of the abstracts adequately reportedauthors,randomisationoroutcome in the results section. According to the multivariable analysis, pharmacological interventions (p=0.018) and funding from the industry (p=0.025) were significantly associated with better reporting quality.

Conclusions

The reporting quality of RCT abstracts presented at SLEEP Annual Meetings was suboptimal. Pharmacological intervention and funding from industry were significant predictors of better reporting quality. Joint efforts by authors and conference committees are needed to enhance the reporting quality of RCT abstracts presented at sleep medicine conferences, and thereby reduce relevant research waste in this field.
Protocol for a feasibility trial to inform the development of a breathlessness rehabilitation programme for chronic obstructive pulmonary disease and chronic heart failure (the COHERE trial)
Authors: Jones Amy V , Evans Rachael A , Esliger Dale W , Sherar Lauren B , Singh Sally J
Published: July 2019

Introduction

Adults with chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) commonly suffer from exertional dyspnoea and fatigue. Exercise training is recommended in the management of both diseases, yet many of the outcome measures traditionally reported are disease specific and may not fully acknowledge the multimorbid older adult. Based on our previous research, a breathlessness rehabilitation programme for patients with COPD/CHF or combined disease has been introduced as a service improvement within University Hospital Leicester National Health Service Trust and has amalgamated aspects of cardiac and pulmonary rehabilitation. This has created an opportunity to expand the outcome measures assessed and introduce a holistic approach in a population that share common symptoms. Therefore, this multisite trial will explore the feasibility of collecting novel outcome markers as part of a comprehensive assessment prior to enrolment in a breathlessness rehabilitation programme for participants with COPD and/or CHF.

Methods and analysis

The rehabilitation programme consists of 12 sessions, twice weekly, over a 6-week period. In addition to usual rehabilitation outcome measures, the trial will collect measures of future cardiometabolic risk including arterial stiffness, body composition, physical activity/sedentary time, frailty and symptom burden in a comprehensive rehabilitation assessment. The primary outcome measures will centre around feasibility (eg, acceptability of the comprehensive rehabilitation assessment, intervention delivery and the experiences and attitudes of healthcare professionals and participants). Focus groups and interviews will be conducted to further explore barriers and facilitators to the operation and participation in a breathlessness rehabilitation programme and the trial. Thematic analysis will be used for the interpretation of all qualitative data.

Ethics and dissemination

The research ethics committee East Midlands Leicester-Central has provided ethical approval for the conduct of this trial. The results of the trial will be disseminated through appropriate conference proceedings and peer-reviewed journals.

Trial registration number

ISRCTN11636308