bluuebunny/crossref_metadata_2025 huggingface dataset:
التباين المكاني ومؤشرات إنتاج مشاريع تربية الدجاج في محافظة دهوك لعام 2015
Authors: S. Nori Karin , Ali Hussein Ahmad
Published: June 2021

يعد مشاريع تربية الدجاج (اللحوم ـ البيض) أحد أهم مشاريع الثروة الحيوانية في العراق والإقليم وانتاجها من أهم مصادر الغذاء التي لايمكن الاستغناء عنه، وإزاء ذلك تزايد الطلب عليها و تحولت تربية الدجاج من المشاريع الصغيرة والمعتمدة على الخبرة الذاتية للمزارعين والفلاحين إلى التربية الكثيفة التجارية وفق استخدام التقنيات الحديثة في المشايع الكبيرة.

على الرغم من وجود (207) مشروعا لتربية الدجاج في المحافظة، إلا أنها في تزايد مستمر يوما بعد يوم نتيجة للطلب المتنامي عليها، بفعل النمو السكاني المتزايد فضلا عن تحسن الوضع الاقتصادي، وإزاء هذه الأهمية جاءت هذه الدراسة بهدف معرفة أعداد وطبيعة توزيع مشاريع تربية الدجاج في المحافظة، ومدى كفاءتها لتلبية احتياجات السوق المحلية، فضلا عن دراسة التباين المكاني لتلك المشاريع على مستوى أقضية المحافظة.

للحصول على بيانات عن تلك المشاريع استخدمت استمارتين للاستبيان، الأولى مؤلفة من (29) سؤالا، تم توزيعها على المستثمرين (أصحاب المشاريع) والعمال اللذين يعملون فيها، اما الاستمارة الثانية موجهة للمستهلكين لقياس رغباتهم في استهلاك الإنتاج المحلي، مكونة من (5) أسئلة، ووفق ما سبق توصلت الدراسة الى وجود تباين مكاني في أعداد مشاريع تربية الدجاج ، مع بروز التباين واضع على مستوى أعداد القاعات والإنتاجية ومهارة العاملين وعلى مستوى أقضية المحافظة.
Participation and Bridging: Involving Etrepreneurs in the Management of the EU Rural Economy
Authors: Zinchuk Tetyana O. , Tarasovych Liudmyla V. , Yaremova Maryna I. , Usiuk Tetiana V. , Kovalchuk Oleksandr D.
Published: June 2021

It has been proved that the implication of the European experience in the development of the rural economy in Ukraine is seen as a necessary attribute of the implementation of its ambitions to participate in the global process of sustainable development. It is emphasised that the asset of EU member states in forming the imperatives of sustainable development is to enhance the role and ensure the participation of all stakeholders in the management of the rural economy. The content of the stakeholder-oriented approach is characterised, and its imperatives in the context of agricultural management are identified. It has been substantiated that the stakeholders of rural economic development are any individuals, communities, groups, or institutions interested in the effective results of this process, which either directly affect them, or which they influence. Identified groups of rural development stakeholders: local government (public sector); business (private sector); household sector; non-governmental non-profit organisations (civil society). They influence or may be affected by decisions of any level of management hierarchy that should be taken into account under the conditions of configuration of their strategic orientations in mechanisms of management of the rural economy. To assess the degree and strength of the impact of stakeholders on the development of the rural economy, an appropriate matrix was formed, which allowed to determine their interests and possible strategic interactions in terms of key, secondary, supportive and passive groups of stakeholders. This is necessary to predict both the partnership and the competitive nature of cooperation, as stakeholders have (potentially have) different interests (economic, social, environmental, informational) and limited or unevenly distributed resources to implement these interests (financial, labour, intellectual, innovative, technological, informational, property, personnel, administrative, etc.). The profile of interests and influence of stakeholders on the development of the rural economy was built with a focus on the territorial community as an object of local impact. The mechanisms and features of attracting entrepreneurs as key stakeholders in rural economy management on the basis of bridging, the principles of which provide systematic, consistent, and well-established cooperation towards the implementation of common strategic objectives, interests, and goals of the rural economy. The possibilities of strategic partnership through the inclusive participation of all stakeholders in the implementation of projects and territorial development plans are outlined. The advantages of implementation in Ukraine of the European experience of attracting stakeholders in management of rural economy have been proven.
Managing Economic Security of Metallurgical Enterprises under the Conditions of Transformation Changes in the Economy
Authors: Ivanova Maryna , Tiutchenko Svitlana , Grosheleva Olena , Fonarova Tetiana , Ryzhkov Eduard
Published: June 2021

The article proposes a method for assessing the level of economic security of metallurgical enterprises by the “pyramid of economic security”. It is based on priority components of economic security, selected for the enterprises under studies, such as the capability of resistance, risk reduction and economic succession, and established indicators of their causal relationships with exogenous and endogenous factors of influence. The assessment results allow differentiating the levels of the enterprise economic security; the practical application of the “pyramid of economic security” will provide a more realistic assessment of the enterprise’s economic security for prompt and effective response to urgent threats and possible risks. The authors have developed a model for assessing the effectiveness of economic security management in enterprises by the rate of changes in the enterprise economic succession; the model is based on the indicators of resource and impact decoupling, financial, social and eco-decoupling.
Modern Business Teaching: The Sable Labor Market Provision for the Emerging Generations
Authors: Lesinskis Kristaps , Mavlutova Inese , Peiseniece Liga , Hermanis Janis , Peiseniece Elina , Pokatayeva Olga
Published: June 2021

Models used in education that were exploited in the 20th century are now under revision, as educators attempt to identify what is suitable to be kept and what needs to be changed and redefined for the 21st century. There are wide discussions on how to appropriately adjust entrepreneurship education methods to the changing expectations of emerging generations. The goal of the study  is to identify  more appropriate teaching methods for entrepreneurship education in the case of Latvia, country that has had one of the highest entrepreneurial activity in the European Union for many years. Conclusion from the primary research done by authors is that sample of respondents representing Generation Z highly value the application and effectiveness of modern teaching methods in entrepreneurship studies, however, the evaluation of different methods differs significantly depending on the type of learning preferred.
Strategic Management Tools for Innovative Development of the Region
Authors: Krasnostanova Nataliia , Yatskevych Inna , Maidaniuk Serhii , Palamarchuk Volodymyr , Pryvalova Nataliia
Published: June 2021

The relevance of the problem under study is due to the fact that at present the dependence of countries and regions on the world economy is increasing, there is a transition to an information society and a knowledge economy, there are changes in the way of life of people, which requires the use of new approaches to managing the development of regions and ensuring their competitiveness. The main priority task of the regional policy aimed at increasing the competitiveness of regions should be the development of their scientific, technological and innovative potential. To do this, it is necessary to find and effectively use tools for the strategic management of innovative development of regions. The purpose of the article is to develop recommendations for managing the innovative development of the region. The leading approach to problem research. The main research methods used within the framework of the article: analysis and synthesis of theoretical and legal materials, statistical analysis of data (indicators of dynamics, structure, incl.). Statistical indicators reflecting the innovative development of the region and other regions directly located in the south of Ukraine in the Black Sea region are considered. The article discusses the concepts of “strategic management”, “innovative development of the region”. Also, the tools of strategic management of innovative development at the regional level were considered, statistical indicators characterising the innovative development of the Odesa region were evaluated. Based on the results of the analysis, the problems of innovative development have been identified and ways to solve them have been developed. The transition of the Ukrainian economy to an innovative path of development requires from the regions special attention to the search and use of internal development reserves, based on the available scientific and intellectual potential. The existing approaches to the effectiveness of the instruments of state strategic management of the innovative development of the country's regions require revision. The priority ways of improving the management tools for regional innovative development are: the development of public consciousness, innovation and entrepreneurial culture; motivation of the population and entrepreneurship to actively innovate; improving the content of specialised training of management personnel for innovative development; algorithmicising the activities of regional leaders in managing regional innovative development. The implementation of the listed areas will contribute to innovative development, an increase in the efficiency of the regional economy, and an increase in the standard of living of the population. Practical significance: The materials of the article are of practical value for improving the strategic management of the innovative development of the region.
Penyuluhan Hukum dan Pendampingan Kepesertaan Jaminan Sosial Tenaga Kerja Sektor Informal Kelompok Tani “Sumber Rejo” Desa Tuwang Kecamatan Karanganyar Kabupaten Demak
Authors: Adillah Siti Ummu , Purnawan Amin , Siti Rodhiyah Dwi Istina Siti Rodhiyah Dwi Istina Siti Rodhiyah Dwi Istina
Published: June 2021

This community service aims to provide knowledge and understanding of employment social security for workers in the informal sector, such as: Doctors, Advocates, Traders, Fishermen, Farmers, Ojek Workers, Becak Workers, and so on, especially for the Tuwang Village "Sumber Rejo" Farmer Group. Karanganyar District, Demak Regency. This community service is expected to provide knowledge and insight to the farming community about the importance of work safety, which in turn is expected to raise awareness to obtain legal protection for labor social security for farmers at work. The method used in this community service is to provide counseling and assistance, through lectures and discussions, which will then be followed up by assisting the farming community to become a participant in employment social security. The results and discussion were community service by providing legal counseling and assistance to farmer groups "Sumber Rejo" regarding the importance of being a participant in the Social Security Workforce for the Informal Sector like farmers, to anticipate work accidents, old age or death. AbstrakPengabdian   masyarakat   ini   bertujuan   untuk   memberikan   pengetahuan   dan pemahaman   tentang jaminan sosial ketenagakerjaan bagi pekerja di sektor informal, seperti: Dokter, Advokat, Pedagang, Nelayan, Petani, Tukang Ojek, Tukang Becak, dan sebagainya, khusunya bagi Kelompok Tani “Sumber Rejo” Desa Tuwang Kecamatan Karanganyar Kabupaten Demak. Pengabdian  masyarakat  ini  diharapkan  dapat memberikan  pengetahuan dan wawasan kepada masyarakat tani tentang pentingnya keselamatan kerja, yang pada akhirnya diharapkan dapat menimbulkan munculnya kesadaran untuk mendapatkan perlindungan hukum atas jaminan sosial ketenagakerjaan terhadap petani pada saat bekerja. Metode yang digunakan  dalam  pengabdian masyarakat ini adalah dengan melakukan penyuluhan dan pendampingan, melalui metode  ceramah dan diskusi, yang selanjutnya akan ditindaklanjuti dengan melakukan pendampingan dibantu oleh kepada masyarakat tani untuk menjadi peserta jaminan sosial ketenagakerjaan. Hasil dan pembahasan  yaitu pengabdian  masyarakat  dengan melakukan penyuluhan  hukum dan pendampingan terhadap kelompok tani “Sumber Rejo” tentang pentingnya menjadi peserta Jaminan Sosial Tenaga Kerja bagi Sektor Informal sperti petani, untuk mengantisipasi terjadinya kecelakaan kerja, memasuki usia tua ataupun kematian.
Lógica militarista y nacionalista versus subjetividad antinacionalista. Los debates intelectuales en torno a la Guerra de Malvinas en la revista Punto de Vista
Authors: Mercader Sofía
Published: June 2021

Este artículo se propone examinar las discusiones intelectuales que se dieron en Argentina en el contexto de la Guerra de Malvinas (1982), haciendo énfasis en la posición adoptada por la revista Punto de Vista (1978-2008). Los objetivos de este artículo son, por una parte, analizar el conflicto de Malvinas en su contexto histórico para, luego, examinar y complejizar la postura sostenida por el grupo de Punto de Vista, que se opuso categóricamente a la invasión militar, sosteniendo así una posición minoritaria dentro del campo intelectual. El artículo sostiene que estas figuras (cuyas voces más salientes fueron las de Carlos Altamirano y Beatriz Sarlo) adoptaron una posición antinacionalista y de oposición al régimen militar, mientras que otros intelectuales igualmente opuestos a la dictadura hicieron caso omiso de los factores contextuales de la guerra y apoyaron el conflicto. A partir del análisis de artículos publicados en Punto de Vista, otros escritos aparecidos en otras revistas de la época y correspondencia personal de los intelectuales estudiados, el artículo también demuestra cómo el grupo de Punto de Vista relacionó la derrota de Malvinas con la transición a la democracia, precipitada por el fin de la guerra a mediados de 1982 y cómo a lo largo de los años insistió, desde la misma posición antinacionalista y minoritaria, en la necesidad de revisar el momento patriótico de 1982 críticamente.
Tradicionalistas y rioplatenses
Authors: Casas Matías Emiliano
Published: June 2021

Este artículo plantea el estudio de las relaciones culturales en el espacio rioplatense entre 1927 y 1948. En particular, se analizan las conexiones entre agrupaciones y figuras del tradicionalismo que, en escenarios urbanos, se congregaban para reivindicar un pasado rural y evocar la figura del gaucho como referencia simbólica para la(s) nación(es). Se considera que la exploración de esa red, forjada centralmente entre Buenos Aires y Montevideo, permite develar la composición de una agenda común que subrayaba las coincidencias culturales entre ambos países y ponía de relieve una identidad rioplatense, al margen de las relaciones estrictamente políticas entre Argentina y Uruguay en el período. Los archivos personales de los tradicionalistas, sumados a un corpus de revistas especializadas y documentación institucional de agrupaciones gauchescas, permiten develar esos vínculos en tres direcciones: el intercambio epistolar a través del Río de la Plata, las repercusiones —públicas y privadas— de eventos vinculados a los intereses tradicionalistas y las empatías gestadas en torno a las colecciones particulares y museos gauchescos.
Diabetes Mellitus e Transtorno Depressivo: a bidirecionalidade entre duas doenças crônicas
Authors: Jardim Renata de Souza , Robbiati Barbara Mafalda , Okamoto Brenda Akemi Gaspi , Junior Edivaldo Pereira de Campos , Rocha Fernanda Luz Neves da , Guiotti Juliana , Salgado Nathalia Di Mase , Guerrero Lorenzo , Corrêa Mônica Isaura
Published: June 2021

Objetivo: Discutir a associação entre a prevalência de depressão em pacientes diabéticos, avaliando aspectos epidemiológicos, psicossociais, fisiopatológicos e o correto manejo clínico. Revisão bibliográfica: Observou-se uma ligação bidirecional entre diabetes e depressão, sendo esta quase duas vezes mais prevalente em pacientes com diabetes tipo 2. Constatações corroboradas pela principal hipótese fisiopatológica encontrada, que une os dois distúrbios, na qual o aumento sustentado de catecolaminas na doença depressiva levaria ao aumento da glicemia, através da diminuição da síntese de insulina ou aumento da resistência periférica a ação da insulina, além dos efeitos neuroquímicos do diabetes sobre os sistemas centrais serotoninérgicos, noradrenérgicos e dopaminérgicos, diminuindo a função destas aminas. Percebe-se ainda a relevância psicossocial dos distúrbios presentes de forma concomitante, associados a uma baixa qualidade de vida, adesão reduzida às prescrições e autogestão, e maior impacto e prevalência de complicações diabéticas, ocasionando um aumento no uso e, consequentemente, nos custos de saúde. Considerações finais: Apesar da clara correlação encontrada entre tais patologias não existem grandes artigos com grupo controle e estudos randomizados que confirmem tal associação.
Structural variation of protein-ligand complexes of the first bromodomain of BRD4
Authors: Guest Ellen , Pickett Stephen , Hirst Jonathan
Published: June 2021

The bromodomain-containing protein 4 (BRD4), a member of the bromodomain and extra-terminal domain(BET) family, plays a key role in several diseases, especially cancers. With increased interest in BRD4 as atherapeutic target, over 300 X-ray crystal structures of the protein in complex with small molecule inhibitorshave become publicly available over the recent decade. In this study, we use this structural information toinvestigate the conformations of the first bromodomain (BD1) of BRD4. Structural alignment shows a highlevel of similarity between the structures of BRD4-BD1, regardless of the bound ligand. We employ WONKA,a tool for detailed analyses of protein binding sites, to compare the active site of over 100 crystal structures,with a focus on the highly conserved network of water molecules, which line the binding pocket of BRD4-BD1.The analysis presented in this work helps guide the selection of the best structure of BRD4-BD1 to use instructure-based drug design, an important approach for faster and more cost-efficient lead discovery.
Label-Free Plasmonic Biosensor for Rapid, Quantitative, and Highly Sensitive COVID-19 Serology: Implementation and Clinical Validation
Authors: Calvo-Lozano Olalla , Sierra MIquel , Soler Maria , Estevez M.-Carmen , Chiscano-camon luis , Ruiz-Sanmartín Adolfo , Ruiz-Rodriguez Juan Carlos , Ferrer Ricard , González-López Juan José , Esperalba Juliana , fernandez-naval Candela , Bueno leticia , López-Aladid Rubén , Torres Antoni , Fernández-Barat Laia , Attoumani Sarah , Charrel Remi , Coutard Bruno , Lechuga Laura M.
Published: June 2021

Serological tests are essential for the control and management of COVID-19 pandemic, not only for current and historical diagnostics but especially for surveillance, epidemiological, and acquired immunity studies. Clinical COVID-19 serology is routinely performed by enzymatic or chemiluminescence immunoassays (i.e., ELISA or CLIA), which provide good sensitivities at the expense of relatively long turnaround times and specialized laboratory settings. Rapid serological tests, based on lateral flow assays, have also been developed and widely commercialized, but they suffer from limited reliability due to relatively low sensitivity and specificity. We have developed and validated a direct serological biosensor assay employing proprietary technology based on Surface Plasmon Resonance (SPR). The biosensor offers a rapid -less than 15 min- identification and quantification of SARS-CoV-2 antibodies directly in clinical samples, without the need of any signal amplification. The portable plasmonic biosensor device employs a custom-designed multi-antigen sensor biochip, combining the two main viral antigens (RBD peptide and N protein), for simultaneous detection of human antibodies targeting both antigens. The SPR serology assay reaches detection limits in the low ng mL-1 range employing polyclonal antibodies as standard, which are well below the commonly detected antibody levels in COVID-19 patients. The assay has also been implemented employing the first WHO approved anti-SARS-CoV-2 immunoglobulin standard. We have carried out a clinical validation with COVID-19 positive and negative samples (n=120) that demonstrates the excellent diagnostic sensitivity (99%) and specificity (100%). This positions our biosensor device as an accurate, robust, and easy-to-use diagnostics tool for rapid and reliable COVID-19 serology to be employed both at laboratory and decentralized settings for the management of COVID-19 patients and for the evaluation of immunological status during vaccination, treatment or in front of emerging variants.
Photodoping and Fast Charge Extraction in Ionic Carbon Nitride Photoanodes
Authors: Adler Christiane , Selim Shababa , Krivtsov Igor , Li Chunyu , Mitoraj Dariusz , Dietzek Benjamin , Durrant James R , Beranek Radim
Published: June 2021

Ionic carbon nitrides based on poly(heptazine imides) (PHI) represent a vigorously studied class of materials with possible applications in photocatalysis and energy storage. Herein, we study, for the first time, the photogenerated charge dynamics in highly stable and binder-free PHI photoanodes using in operando transient photocurrents and spectroelectrochemical photoinduced absorption measurements. We discover that light-induced accumulation of long-lived trapped electrons within the PHI film leads to effective photodoping of the PHI film, resulting in a significant improvement of photocurrent response due to more efficient electron transport. While photodoping has been previously reported for various semiconductors, it has never been shown before for carbon nitride materials. Furthermore, we find that the extraction kinetics of untrapped electrons are remarkably fast in these PHI photoanodes, with electron extraction times (ms) comparable to those measured for commonly employed metal oxide semiconductors. These results shed light on the excellent performance of PHI photoanodes in alcohol photoreforming, including very negative photocurrent onset, outstanding fill factor, and the possibility to operate under zero-bias conditions. More generally, the here reported photodoping effect and fast electron extraction in PHI photoanodes establish a strong rationale for the use of PHI films in various applications, such as bias-free photoelectrochemistry or photobatteries.
Palladium-Catalyzed Decarbonylative Catellani Reaction
Authors: Dai Huixiong , Han Ming-Liang , Chen Jun-Jie , Xu Hui , Huang Wei , Liu Yue-Wen , Wang Xing , Liu Min , Guo Zi-Qiong , Huang Zhi-Cong
Published: June 2021

The transition metal-catalyzed Catellani reaction of aryl halides has drawn significant attentions as an efficient and practical tool for the synthesis of substituted arenes. We describe herein the palladium-catalyzed, norbornene (NBE)-mediated synthesis of polysubstituted arenes from aromatic acids via decarbonylative Catellani reaction. A variety of alkenyl, alkyl, aryl and sulfur moieties could be conveniently introduced into the ipso-positions of aromatic thioesters. By merging carboxyl-directed C−H functionalization and the classical Catellani reactions, our protocol allowed the construction of 1,2,3-trisubstituted and 1,2,3,4-tetrasubstituted arenes from simple aromatic acids. Furthermore, the late-stage functionalization of a series of drug molecules highlights the potential utility of the reaction.
Looking Beyond Adsorption Energies to Understand Interactions at Surface Using Machine Learning
Authors: Agarwal Sheena , Joshi Kavita , Agrawal Sheena
Published: June 2021

Abstract

Identifying factors that influence interactions at the surface is still an active area of research. In this study, we present the importance of analyzing bondlength activation, while interpreting Density Functional Theory (DFT) results, as yet another crucial indicator for catalytic activity. We studied the

adsorption of small molecules, such as O 2 , N 2 , CO, and CO 2 , on seven face-centered cubic (fcc) transition metal surfaces (M = Ag, Au, Cu, Ir, Rh, Pt, and Pd) and their commonly studied facets (100, 110, and 111). Through our DFT investigations, we highlight the absence of linear correlation between adsorption energies (E ads ) and bondlength activation (BL act ). Our study indicates the importance of evaluating both to develop a better understanding of adsorption at surfaces. We also developed a Machine Learning (ML) model trained on simple periodic table properties to predict both, E ads and BL act . Our ML model gives an accuracy of Mean Absolute Error (MAE) ∼ 0.2 eV for E ads predictions and 0.02 Å for BL act predictions. The systematic study of the ML features

that affect E ads and BL act further reinforces the importance of looking beyond adsorption energies to get a full picture of surface interactions with DFT.
Spectroscopic Investigation of Polyaniline Co Poly Meta Amino Benzene Sulfonic Acid
Authors: Ray Jayanta , Bhowmik Leena
Published: June 2021

Similar to metals, conducting polymers possess an extraordinary ability to conduct electricity due to their intrinsic properties. There has been considerable focus on the synthesis and development of such materials for a wide variety of applications. In this regard, polyaniline and its derivatives have versatile applications including use as active electronic material, fabrication of modified electrode, sensors, in secondary batteries and in microelectronic and electrochromic device. Introduction of potential polymers like PAN and PPY or PTF as conductive co-polymer, interpenetrating network or blends would be a challenging step towards the preparation of novel and cheap material with modified antistatic properties. In this work we used poly (m-amino benzene sulfonic acid) and poly aniline for the preparation of composite. Aniline and m-amino benzene sulfonic acid can be fast polymerized in water to yield conducting nano composites. The composites were easily water dispersable and showed prolonged stability.
Controlling Amphiphilic Polymer Folding Beyond the Primary Structure with Protein-Mimetic Diphenylalanine
Authors: Warren Jacqueline L. , Dykeman-Bermingham Peter , Knight Abigail
Published: June 2021

While methods for polymer synthesis have proliferated, their functionality pales in comparison to natural biopolymers – strategies are limited for building the intricate network of noncovalent interactions necessary to elicit complex, protein-like functions. Using a bioinspired diphenylalanine acrylamide (FF) monomer, we explored the impact of various non-covalent interactions in generating ordered assembled structures. Amphiphilic copolymers were synthesized that exhibit β-sheet-like secondary structure upon collapsing into single-chain assemblies in aqueous environments. Systematic analysis of a series of amphiphilic copolymers illustrated that the collapse is primarily driven by hydrophobic forces. Hydrogen-bonding and aromatic interactions stabilize local structure, as β-sheet-like interactions were identified via circular dichroism and thioflavin T fluorescence. Similar analysis of phenylalanine (F) and alanine-phenylalanine acrylamide (AF) copolymers found that distancing the aromatic residue from the polymer backbone is sufficient to induce β-sheet-like secondary structure akin to the FF copolymers; however, the interactions between AF subunits are less stable than those formed by FF. Further, hydrogen-bond donating hydrophilic monomers disrupt internal structure formed by FF within collapsed assemblies. Collectively, these results illuminate design principles for the facile incorporation of multiple facets of protein-mimetic, higher-order structure within folded synthetic polymers.
Estimation of Binding Rates and Affinities from Multiensemble Markov Models and Ligand Decoupling
Authors: Ge Yunhui , Voelz Vincent
Published: June 2021

Accurate and efficient simulation of the thermodynamics and kinetics of protein-ligand interactions is crucial for computational drug discovery. Multiensemble Markov Model (MEMM) estimators can provide estimates of both binding rates and affinities from collections of short trajectories, but have not been systematically explored for situations when a ligand is decoupled through scaling of non-bonded interactions. In this work, we compare the performance of two MEMM approaches for estimating ligand binding affinities and rates: (1) the transition-based reweighting analysis method (TRAM) and (2) a Maximum Caliber (MaxCal) based method. As a test system, we construct a small host-guest system where the ligand is a single uncharged Lennard-Jones (LJ) particle, and the receptor is an 11-particle icosahedral pocket made from the same atom type. To realistically mimic a protein-ligand binding system, the LJ ε parameter was tuned, and the system placed in a periodic box with 860 TIP3P water molecules. A benchmark was performed using over 80 μs of unbiased simulation, and an 18-state Markov state model used to estimate reference binding affinities and rates. We then tested the performance of TRAM and MaxCal when challenged with limited data. Both TRAM and MaxCal approaches perform better than conventional MSMs, with TRAM showing better convergence and accuracy. We find that subsampling of trajectories to remove time correlation improves the accuracy of both TRAM and MaxCal, and that in most cases only a single biased ensemble to enhance sampled transitions is required to make accurate estimates.
SCONES: Self-Consistent Neural Network for Protein Stability Prediction Upon Mutation
Authors: Samaga B L Yashas , Raghunathan Shampa , Priyakumar U. Deva
Published: June 2021

Engineering proteins to have desired properties by mutating amino acids at specific sites is commonplace. Such engineered proteins must be stable to function. Experimental methods used to determine stability at throughputs required to scan the protein sequence space thoroughly are laborious. To this end, many machine learning based methods have been developed to predict thermodynamic stability changes upon mutation. These methods have been evaluated for symmetric consistency by testing with hypothetical reverse mutations. In this work, we propose transitive data augmentation, evaluating transitive consistency, and a new machine learning based method, first of its kind, that incorporates both symmetric and transitive properties into the architecture. Our method, called SCONES, is an interpretable neural network that estimates a residue's contributions towards protein stability dG in its local structural environment. The difference between independently predicted contributions of the reference and mutant residues in a missense mutation is reported as dG. We show that this self-consistent machine learning architecture is immune to many common biases in datasets, relies less on data than existing methods, and is robust to overfitting.
ĐÁNH GIÁ TÌNH HÌNH SINH TRƯỞNG CỦA CÁC LOÀI CÂY BẢN ĐỊA THEO CÁC DẠNG LẬP ĐỊA KHÁC NHAU: NGHIÊN CỨU TRƯỜNG HỢP VỚI 3 LOÀI CÂY LIM XANH, TRÁM TRẮNG VÀ HUỶNH TẠI TỈNH QUẢNG BÌNH
Authors: Thành Trần Trung , Hoàng Hồ Đắc Thái , Văn Nguyễn Phương
Published: June 2021

Bài báo trình bày kết quả đánh giá sự phù hợp, sinh trưởng và phát triển của các loài cây trồng bản địa trên các dạng lập địa khác nhau tại tỉnh Quảng Bình. Kết quả phân tích tại các ô theo dõi đo đếm và bố trí thí nghiệm trên các loài Lim xanh (Erythrophleum fordi Oliv), Trám trắng (Canarium album Raeusch), Huỷnh (Tarrietia javanica Blume) từ năm 1 đến năm 6 cho thấy tỷ lệ sống của các loài đạt khá cao, trên 82%; Lượng tăng trưởng bình quân tới tuổi 6 về đường kính của các loài cây dao động từ 1,46-1,95cm/năm; Biện pháp xử lý thự bì có ảnh hưởng rõ rệt tới sinh trưởng chiều cao và đường kính ngang ngực của các loài. Công thức xử lý thực bì phù hợp là xử lý thực bì theo băng. Các dạng lập địa khác nhau ảnh hưởng đến tỷ lệ sống và các chỉ tiêu sinh trưởng của các loài. Cây Lim xanh và cây Trám trắng thích hợp hơn với dạng lập địa B.
THỰC TRẠNG CHUYỂN NHƯỢNG QUYỀN SỬ DỤNG ĐẤT CỦA HỘ GIA ĐÌNH, CÁ NHÂN TRÊN ĐỊA BÀN HUYỆN KRÔNG PẮK, TỈNH ĐẮK LẮK
Authors: Tuyết Trần Thị Ánh , Bình Nguyễn Văn
Published: June 2021

Nghiên cứu này tập trung vào thực trạng chuyển nhượng quyền sử dụng đất của hộ gia đình, cá nhân trên địa bàn huyện Krông Pắk, tỉnh Đăk Lăk trong giai đoạn 2016–2019. Bài báo sử dụng 3 phương pháp với tổng số hộ điều tra, phỏng vấn trên địa bàn 4 xã/thị trấn là 99 hộ gia đình và 10 cán bộ quản lý. Kết quả nghiên cứu cho thấy thực trạng công tác chuyển nhượng quyền sử dụng đất của các hộ gia đình, cá nhân trên địa bàn huyện Krông Pắk giai đoạn 2016–2019 có 17.725 hồ sơ đăng ký chuyển nhượng quyền sử dụng đất với tổng diện tích đất chuyển nhượng là 48.205.744,3 m2, nhưng phân bố không đồng đều giữa các đơn vị hành chính xã, thị trấn. Loại đất chuyển nhượng chiếm tỷ lệ về diện tích lớn trên địa bàn huyện là đất nông nghiệp với 11.930 hồ sơ trong giai đoạn 2016–2019, đối với đất ở chỉ có 5.795 hồ sơ. Qua khảo sát, phỏng vấn trên địa bàn huyện Krông Pắk cho thấy: Ý thức của người dân trong việc chấp hành các quy định của pháp luật về đất đai ngày càng cao. Hầu hết các trường hợp thực hiện quyền chuyển nhượng quyền sử dụng đất đã đăng ký tại cơ quan Nhà nước có thẩm quyền.
BẤT CẬP TRONG HOẠT ĐỘNG ÁP DỤNG ÁN LỆ CỦA TÒA ÁN NHÂN DÂN Ở VIỆT NAM HIỆN NAY
Authors: Thị Hoài Thương Nguyễn
Published: June 2021

Hiện nay, trong xu thế hội nhập kinh tế quốc tế, khi mà các tranh chấp kinh doanh, thương mại ngày càng nhiều và phức tạp, việc áp dụng án lệ để giải quyết các tranh chấp đó được xem là một trong các giải pháp hữu hiệu. Tuy nhiên, thực tiễn cho thấy trong quá trình giải quyết các tranh chấp, còn nhiều bất cập trong việc ban hành, công bố và sử dụng án lệ dẫn đến hiệu quả áp dụng án lệ còn thấp. Bài viết tập trung phân tích một số vấn đề còn hạn chế trong quá trình áp dụng án lệ từ đó đề xuất giải pháp nhằm nâng cao hiệu quả áp dụng án lệ để giải quyết các tranh chấp trong kinh doanh, thương mại Việt Nam hiện nay.
PHÁP LUẬT VỀ TRUYỀN THÔNG QUA MẠNG XÃ HỘI, QUA THỰC TIỄN TRUYỀN THÔNG TUYỂN SINH TẠI ĐẠI HỌC LUẬT, ĐẠI HỌC HUẾ
Authors: Minh Tiến Ngô , Trang Đỗ Thị Quỳnh
Published: June 2021

Cùng với sự phát triển của internet và mạng xã hội như hiện nay đã làm thay đổi cách thức thực hiện tuyển sinh của các trường đại học, các cơ sở đào tạo. Ứng dụng các công cụ của truyền thông trực tuyến trong công tác tuyển sinh đang trở thành cách làm hiệu quả để thu hút người học hiện nay. Bài viết đề cập đến việc sử dụng các công cụ truyền thông trực tuyến cũng như các giải pháp để nâng cao hiệu quả hoạt động tuyển sinh đại học chính quy tại Trường Đại học Luật, Đại học Huế
NHỮNG TỒN TẠI TRONG HOẠT ĐỘNG GIÁM SÁT CỦA MẶT TRẬN TỔ QUỐC VIỆT NAM ĐỐI VỚI HỆ THỐNG CƠ QUAN DÂN CỬ Ở VIỆT NAM HIỆN NAY
Authors: Hà Đặng Thị
Published: June 2021

Bài viết đề cập đến một số tồn tại trong hoạt động giám sát của Mặt trận Tổ quốc Việt Nam đối với các cơ quan dân cử. Qua đó, tác giả đưa ra một số kiến nghị nhằm nâng cao hiệu quả hoạt động giám sát của Mặt trận Tổ quốc đối với các cơ quan dân cử ở Việt Nam hiện nay.
Time series analysis and forecasting of indian economy
Authors: M Vivek Prabu , R Karthika
Published: June 2021

India being an entity of highly populated nation across the globe, stands as a developing country with a perceptible economic status relative to the other countries. Integrals such as socio-political activities exert influence on the ups and downs of the economic development of any country. India was the sprightly growing economy in the early 2000’s but at the neoteric time, it is said that the economical maneuver of India has been directing towards the downhill. Prepending to the outbreak of Covid-19, the GDP discern to deflate below 0% at the onset but has shown a substantial upward movement post lockdown period. Thus, it can be ensured that the economical movement of India is progressing in a consistent approach despite the decline. In this paper, we aim at analyzing the historical movement of Indian economy in view with the recent up and downs and thereby also forecast the future economic movement with the help of time series.
Management of Persistent Perfusion of an Excluded Popliteal Artery Segment Following Penetrating Vascular Injury
Authors: Knipp Brian S , Andrews Shalimar J , Werwath Halley R , Sutton Daniel M
Published: June 2021

Exclusion and bypass for penetrating vascular injury remains the gold standard. Persistent hemorrhage via retrograde perfusion of the injured vessel by collateral vessels is rare and may, therefore, be overlooked as a cause of postoperative hemorrhage following bypass for vascular injury. We report a case of a 49-year-old male who presented to our institution 2 weeks following a bypass graft of his popliteal artery after sustaining a gunshot wound to the vessel. His ongoing complaints of pain and pressure in the popliteal fossa were found to be related to persistent collateral perfusion of the injured segment of his proximal popliteal artery. His symptoms resolved completely following coil embolization of the injured native artery. While quite rare in clinical practice, the pathophysiology of this case is analogous to persistent perfusion of the aneurysm sac following open abdominal aortic aneurysm repair or bypass and exclusion of a popliteal artery. In the setting of bypass grafting for vascular trauma, postoperative hemorrhage or compressive symptoms should prompt a complete evaluation for a potentially missed patent collateral vessel.
CT-Guided Placement of a Neuromonitoring Suite in Swine for Trauma and Resuscitation Research
Authors: Bonin Janet , Abdou Hossam , Edwards Joseph , Patel Neerav , Richmond Michael , Elansary Noha , Poe Kelly , Morrison Jonathan J
Published: June 2021

Background: In this manuscript, we aim to describe a standardized method for placement of a neuromonitoring suite into the brain of a porcine model using computed tomography (CT) guidance for use in trauma and resuscitation research.
Methods: A baseline CT allowed for precise planning of the placement of the neuromonitoring suite including measurement of skull thickness at the location of the intended burr hole. After the burr hole was drilled, three neuromonitoring probes (pressure catheter, temperature probe, and laser doppler flow probe) were advanced into the brain parenchyma of the swine. A subsequent CT confirmed appropriate placement of the neuromonitoring suite.
Results: Effective placement of the neuromonitoring suite was accomplished successfully and without complication in six Yorkshire swine. Mean duration of the procedure was 49.6±6.3 min. Representative data from one animal include the following presented as mean ± standard deviation: intracranial pressure of 10±0 mmHg, cerebral perfusion pressure of 61±1 mmHg, intracranial temperature of 34.8±0 °C, and brain perfusion of 704±13 relative perfusion units.
Conclusions: This CT-guided method facilitates placement of a neuromonitoring suite in a safe and reliable manner. The use of a neuromonitoring suite using CT may offer valuable insight into cerebral perfusion in the context of endovascular resuscitation.
Transitional Justice: Images and Memories
Authors: Buettner Angelika
Published: June 2021

No description supplied
Examining the Impact of PP 23/2018 policy through the Tax Compliance Factor of Tanah Abang Traders
Authors: P Wardinto , . Gunadi
Published: June 2021

This study aims to examine the factors that can affect tax compliance at Tanah Abang Market traders, which are the tax rate, perceived opportunity to evade, legal certainty, and group influence. This study uses a quantitative method with a positivism approach which examines social phenomena and captures the perceptions of MSEs actors on the determinants of tax compliance. The sample in this study were 154 MSEs respondents in Tanah Abang Market that were scope into Central Jakarta Regional Tax Office, both private individuals and corporate taxpayers. The results of the study revealed that the tax rate, perceived opportunity to evade, legal certainty, and group influence have a positive effect on tax compliance at Tanah Abang Market traders, but not significant only in the tax rate variable. This is very useful for the DGT authority and the Fiscal Policy Agency as policymakers that the reduction in tax rates does not affect the compliance behavior of MSEs traders and increase monitoring of compliance with MSEs taxpayers through derivative regulations on the implementation of supervision of MSEs taxpayers.
Abrupt termination of the 2019/20 influenza season following preventive measures against COVID-19 in Denmark, Norway and Sweden
Authors: Emborg Hanne-Dorthe , Carnahan AnnaSara , Bragstad Karoline , Trebbien Ramona , Brytting Mia , Hungnes Olav , Byström Emma , Vestergaard Lasse S
Published: June 2021

Background

In mid-March 2020, a range of public health and social measures (PHSM) against the then new coronavirus disease (COVID-19) were implemented in Denmark, Norway and Sweden.

Aim

We analysed the development of influenza cases during the implementation of PHSM against SARS-CoV-2 in the Scandinavian countries.

Method

Based on the established national laboratory surveillance of influenza, we compared the number of human influenza cases in the weeks immediately before and after the implementation of SARS-CoV-2 PHSM by country. The 2019/20 influenza season was compared with the five previous seasons.

Results

A dramatic reduction in influenza cases was seen in all three countries, with only a 3- to 6-week duration from the peak of weekly influenza cases until the percentage dropped below 1%. In contrast, in the previous nine influenza seasons, the decline from the seasonal peak to below 1% of influenza-positive samples took more than 10 weeks.

Conclusions

The PHSM against SARS-CoV-2 were followed by a dramatic reduction in influenza cases, indicating a wider public health effect of the implemented measures.
Museu virtual do Instituto de Física da Universidade Federal do Rio de Janeiro: virtualidade, memória e museu
Authors: Teixeira Robson da Silva
Published: June 2021

O estudo analisou as questões que envolvem o Museu Virtual do Instituto de Física da Universidade Federal do Rio de Janeiro (IF UFRJ), um espaço cibernético voltado para a memória institucional do IF UFRJ, que em 2021 faz 57 anos, e ocupa um lugar de destaque entre as instituições de ensino e pesquisa no Brasil. Dentro deste quadro, as metas foram atualizar e revisar os tópicos que compõem a ferramenta de disseminação da informação; ou seja, a inclusão de fotos do Professor Fundador Plínio Sussekind Rocha e da Professora Sarah de Castro Barbosa no tópico Fotografias; organização de conteúdo para o tópico Levantamento documental e elaboração de um termo de consentimento, denominado carta de autorização para o tópico história oral, que é composto por entrevistas com os Professores Eméritos e ex-alunos da Instituição. Para cumprir este propósito, a metodologia da pesquisa foi dividida em etapas: elaboração de pesquisa iconográfica para coletar fotografias; levantamento documental com o intuito de coletar documentos que abordavam o Instituto e seus Professores Fundadores; e entrevista-narrativa com os Professores Eméritos e Ex-alunos do IF UFRJ Erasmo Madureira Ferreira, Fernando de Souza Barros, Herch Moysés Nussenzveig, Nelson Velho de Castro Faria, Nicim Zagury, Takeshi Kodama, Leandro Salazar e Máximo Ferreira da Silveira. Para a realização desta última etapa foi necessário a elaboração de um instrumento para coleta de dados, uma carta de autorização que permite a disseminação das informações recuperadas através das entrevistas. A coleta de dados ocorreu no período de junho a dezembro de 2018. Concluí-se que o serviço online está atualizado, com conteúdo revisado e dentro dos padrões; o Museu Virtual do IF UFRJ é um patrimônio cultural científico que cumpre o seu papel de preservar e disseminar informação fazendo com que a unidade de informação busque realizar um trabalho ligado aos interesses da comunidade científica, onde ela participa, interroga e descobre valores, além de poupar o tempo do usuário, através da otimização do serviço.
Publicações webjornalísticas na divulgação da Biblioteca do Instituto Federal de Educação, Ciência e Tecnologia Santa Catarina
Authors: Muniz Jaison , Bedin Jéssica , Sena Priscila Machado Borges
Published: June 2021

Com o objetivo de analisar as publicações institucionais on-line que apresentaram conteúdos relacionados à Biblioteca do Instituto Federal de Educação, Ciência e Tecnologia Santa Catarina (IFSC) – Campus Lages entre os anos de 2012 e 2018, realizou-se uma pesquisa descritiva quantitativa, coletando-se os dados contidos no Portal institucional e no site local do IFSC – Campus Lages. No entanto, não se excluiu em sua totalidade as demais publicações institucionais. Foram analisadas a quantidade, variação periódica, reprodução, proporcionalidade, assuntos mais abordados e publicados e migração de publicações entre os canais. Dos resultados, destaca-se que, aproximadamente 60% das publicações sobre o Campus Lages, publicadas no Portal do IFSC, em 2012, divulgavam ações e atividades relacionadas à Biblioteca. Também se constatou que, os assuntos que mais despertaram o interesse do jornalismo institucional foram os eventos, concursos culturais e exposições artísticas. No total, encontrou-se nos websites 72 publicações entre 2012 e 2018. No entanto, considerando as publicações de interesse geral e as reproduzidas, a proporção de postagens sobre ações e atividades desenvolvidas pela Biblioteca, durante os sete anos, foi de aproximadamente 7% de publicações no site do Campus e 20% no Portal da instituição. Desta forma, pode-se inferir que, o setor da Biblioteca do IFSC – Campus Lages contribuiu de maneira significativa para o número de publicações institucionais até o ano de 2018. Esse resultado está relacionado com diversos fatores, entre eles, a realização e promoção de iniciativas que resultam em conteúdo com potencial de interesse jornalístico e de divulgação.
Por uma sociologia imaginativa: o presente do passado no processo de cristalização cultural
Authors: Maia Manuela Eugênio , Barrancos Jacqueline Echeverría
Published: June 2021

O objetivo deste artigo é analisar o processo de cristalização cultural no âmbito da memória coletiva para a Ciência da Informação a partir da abordagem da sociologia imaginativa. O método se dá a partir da analítica filosófica foucaltiana, interpretou-se práticas do vivido, enquanto experiências do cotidiano, e de discursos difundidos no Facebook, estabelecendo reflexões acerca dos processos de cristalização cultural à luz da sociologia imaginativa. Como resultado, percebe-se que a cristalização cultural é um movimento que pode promover falaciosa narrativa harmônica e de retorno ao passado. A memória coletiva, quando usada para respaldar um processo de purificação cultural, pode comprometer o pensamento social e científico em uma configuração linear. O vivido e suas ações cotidianas podem trazer consequências no contexto da marginalização e da própria construção da ciência. Conclui-se, seguindo a citada perspectiva sociológica, que é fundamental superar a noção de harmonia, de artificialidade parcial e tendenciosa e de compreensão de hierarquização das ciências. Esse processo de cristalização cultural para a Ciência da Informação pode se dar por meio da analítica da sociologia imaginativa e do uso estratégico o fenômeno do "entranhamento", tratando-se de uma perspectiva pautada na contraposição do dual e da fragmentação.
Resenha do livro "Uma Breve História da Ciência" de Patricia Fara
Authors: Fell André Felipe de Albuquerque , Fell Nilke Silvania Pizziolo , Martins Daniel Felipe Victor
Published: June 2021

Resenha do livro "Uma Breve História da Ciência" de Patricia Fara. Parte-se de uma análise descritiva da obra para então refletir sobre os quatro mil anos de história da ciência apresentados pela autora.