bluuebunny/crossref_metadata_2025 huggingface dataset:
The High Priestess
Authors: Muñoz Carli
Published: September 2023

Abstract: Beginning with his first reading of Aldous Huxley’s The Doors of Perception, Carli Muñoz recounts the various intersection of his LSD trips, musical career as part of The Living End, and life in Puerto Rico. Through this heightened state, Muñoz shows how the experience of music changed and readjusted the way musicians listened and composed music in the 1960s.
TWINS: improved spatial and angular phase calibration for holography
Authors: Supikov Alexey , Mefenza Nentedem Michael , Grunnet-Jepsen Anders , Azuma Ronald T.
Published: September 2023

We present TWINS (TWo INclining Slits), a method for characterizing phase spatial light modulators (SLMs), inspired by Young interferometry. TWINS is an elegant and versatile approach, using minimal equipment and alignment. It measures phase response locally rather than globally, both horizontally and vertically, with high resolution and at wide angles. It can also measure beam intensity profiles as directly seen by the SLM. TWINS characterizes the anisotropic aberrations in the mainstream models of liquid crystal phase SLMs, which is crucial to improve hologram quality. Compensating for anisotropic aberrations measured by TWINS improved the image quality of planar holograms by 10 dB.
Narrow intensity range optical anisotropy in air induced by a femtosecond laser breakdown
Authors: Ushakov Aleksandr , Chizhov Pavel , Bukin Vladimir , Dolmatov Timophey , Garnov Sergey
Published: September 2023

In this paper, we study the optical anisotropy induced by femtosecond laser radiation in air during an optical breakdown. Using a transverse pump-probe technique, we demonstrate that this anisotropy appears in a narrow range of pump intensities, which are close to the optical breakdown threshold in air and lead to a phase shift of probe radiation, polarized collinear to the pump. The intensity range where an induced intense anisotropy occurs makes it possible to estimate the magnitude of the 5th-order Kerr nonlinear refractive index component in air.
Analytical solutions for electromagnetic surface states at the interface between metal and gyromagnetic media
Authors: Zheng Yidong , Chen Jianfeng , Ji Zitao , Lin Hao , Li Zhi-Yuan
Published: September 2023

We systematically study the surface states at the interface between semi-infinite metal and gyromagnetic media, considering three orthogonal magnetization directions. By solving a full vectorial polarization-complete evanescent wave equation derived from Maxwell’s equations and all four boundary conditions, we obtain rigorous analytical solutions for the surface states. All analytical dispersion equations and field equations under the three configurations are solved. Simultaneously, the solutions also reveal the intriguing features of surface plasmon polaritons (SPPs) under the gyromagnetic effect. In the polar configuration (where the magnetization is perpendicular to the interface), the gyromagnetic effect uniquely results in candlelight-like field patterns in SPP. In the transversal configuration (where the magnetization is parallel to the interface and perpendicular to propagation), the unidirectional magnetic surface state is found. In the longitudinal configuration (where the magnetization is parallel to propagation), the SPP also exhibits candlelight-like field patterns but manifests a different polarization from the polar configuration. Our results reveal peculiar behaviors of SPPs under the gyromagnetic effect and would deepen the understanding of the magneto-optical effect on interfaces.
High-sensitivity extreme-ultraviolet transient absorption spectroscopy enabled by machine learning
Authors: Gutberlet Tobias , Chang Hung-Tzu , Zayko Sergey , Sivis Murat , Ropers Claus
Published: September 2023

We present a novel denoising scheme for spectroscopy experiments employing broadband light sources and demonstrate its capabilities using transient absorption measurements with a high-harmonic source. Our scheme relies on measuring the probe spectra before and after interacting with the sample while capturing correlations between spectral components through machine learning approaches. With the present setup we achieve up to a tenfold improvement in noise suppression in XUV transient absorption spectra compared to the conventional pump on/ pump off referencing method. By utilizing strong spectral correlations in source fluctuations, the use of an artificial neural network facilitates pixel-wise noise reduction without requiring wavelength calibration of the reference spectrum. Our method can be adapted to a wide range of experiments and may be particularly advantageous for low repetition-rate systems, such as free electron lasers as well as laser-driven plasma and HHG sources. The enhanced sensitivity enables the investigation of subtle electron and lattice dynamics in the weak excitation regime, which is relevant for studying photovoltaics and photo-induced phase transitions in strongly correlated materials.
Spiral-phase-objective for a compact spiral-phase-contrast microscopy
Authors: Lee Dong-Ho , Lee Sunwoo , Bae Ji Yong , Hur Hwan , Hyun Sangwon , Lee Kye-Sung , Chang Ki Soo , Pak Soojong , Kim Dong Uk , Jong Kim I
Published: September 2023

Spiral-phase-contrast imaging, which utilizes a spiral phase optical element, has proven to be effective in enhancing various aspects of imaging, such as edge contrast and shadow imaging. Typically, the implementation of spiral-phase-contrast imaging requires the formation of a Fourier plane through a 4f optical configuration in addition to an existing optical microscope. In this study, we present what we believe to be a novel single spiral-phase-objective, integrating a spiral phase plate, which can be easily and simply applied to a standard microscope, such as a conventional objective. Using a new hybrid design approach that combines ray-tracing and field-tracing simulations, we theoretically realized a well-defined and high-quality vortex beam through the spiral-phase-objective. The spiral-phase-objective was designed to have conditions that are practically manufacturable while providing predictable performance. To evaluate its capabilities, we utilized the designed spiral-phase-objective to investigate isotropic spiral phase contrast and anisotropic shadow imaging through field-tracing simulations, and explored the variation of edge contrast caused by changes in the thickness of the imaging object.
Propagation dynamics of the controllable circular Airyprime beam in the Kerr medium
Authors: Yang Shuo , Yu Peixin , Wu Jianwen , Zhang Xiao , Xu Zhen , Man Zhongsheng , Ge Xiaolu , Fu Shenggui , Lei Chengxin , Chen Chidao , Deng Dongmei , Zhang Liping
Published: September 2023

In this paper, we study the propagation dynamics of the circular Airyprime beam (CAPB) in the Kerr medium for the first time. We investigate the effects of the astigmatism factor, the chirp factor, and vortices on the CAPB propagating in the Kerr medium. At the same time, we are also introducing a special-shaped Airyprime beam (SAPB) during its propagation. The transmission characteristics of the CAPB and the SAPB in the Kerr medium are compared under identical conditions. Our theoretical results provide additional possibilities for CAPB modulation in the Kerr medium, thereby promising wider applicability of CAPB in various research areas.
Improving the imbalance of the light intensity of 3D wire-frame projection with electro-holography by superimposing a phase error
Authors: Shiina Nobuya , Nishitsuji Takashi , Asaka Takuya
Published: September 2023

The CG-line method is an algorithm for generating computer-generated holograms (CGHs), a digitally recording medium for three-dimensional images in electro-holography. Since the CG-line method is specialized for projecting three-dimensional wireframe objects, it can calculate CGH with a very low computational load. However, the reconstructed image of the conventional CG-line method suffers from unintended light imbalance depending on the object shape, which disturbs the understandability of the projecting image. Therefore, we propose a method for reducing light imbalance by imposing phase error that controls light according to the line shape. Consequently, we reduced light imbalance by maintaining the high computational speed.
Fluorescence lifetime imaging for explosive detection
Authors: Matheson Andrew B. , Ogugu Edward B. , Gillanders Ross N. , Turnbull Graham A. , Henderson Robert
Published: September 2023

In this Letter, a time-resolved 120 × 128 pixel single-photon avalanche diode (SPAD) sensor is used in conjunction with an array of organic semiconductor films as a means of detecting the presence of explosive vapors. Using the spatial and temporal resolution of the sensor, both fluorescence intensity and fluorescence lifetime can be monitored on a pixel-by-pixel basis for each of the polymer films arranged in a 2 × 2 grid. This represents a significant improvement on similar systems demonstrated in the past, which either offer spatial resolution without the temporal resolution required to monitor lifetime or offer only a single bulk measurement of lifetime and intensity without the spatial resolution. The potential of the sensing system is demonstrated using vapors of DNT, and differing responses for each of the four polymer films is observed. This system has clear applications as the basis of a portable chemical fingerprinting tool with applications in humanitarian demining and security.
Construction of an artificial phosphoketolase pathway that efficiently catabolizes multiple carbon sources to acetyl-CoA
Authors: Yang Yiqun , Liu Yuwan , Zhao Haodong , Liu Dingyu , Zhang Jie , Cheng Jian , Yang Qiaoyu , Chu Huanyu , Lu Xiaoyun , Luo Mengting , Sheng Xiang , Zhang Yi-Heng P. J. , Jiang Huifeng , Ma Yanhe
Published: September 2023

The canonical glycolysis pathway is responsible for converting glucose into 2 molecules of acetyl-coenzyme A (acetyl-CoA) through a cascade of 11 biochemical reactions. Here, we have designed and constructed an artificial phosphoketolase (APK) pathway, which consists of only 3 types of biochemical reactions. The core enzyme in this pathway is phosphoketolase, while phosphatase and isomerase act as auxiliary enzymes. The APK pathway has the potential to achieve a 100% carbon yield to acetyl-CoA from any monosaccharide by integrating a one-carbon condensation reaction. We tested the APK pathway in vitro, demonstrating that it could efficiently catabolize typical C1-C6 carbohydrates to acetyl-CoA with yields ranging from 83% to 95%. Furthermore, we engineered Escherichia coli stain capable of growth utilizing APK pathway when glycerol act as a carbon source. This novel catabolic pathway holds promising route for future biomanufacturing and offering a stoichiometric production platform using multiple carbon sources.
Bicc1 ribonucleoprotein complexes specifying organ laterality are licensed by ANKS6-induced structural remodeling of associated ANKS3
Authors: Rothé Benjamin , Ikawa Yayoi , Zhang Zhidian , Katoh Takanobu A. , Kajikawa Eriko , Minegishi Katsura , Xiaorei Sai , Fortier Simon , Dal Peraro Matteo , Hamada Hiroshi , Constam Daniel B.
Published: September 2023

Organ laterality of vertebrates is specified by accelerated asymmetric decay of Dand5 mRNA mediated by Bicaudal-C1 (Bicc1) on the left side, but whether binding of this or any other mRNA to Bicc1 can be regulated is unknown. Here, we found that a CRISPR-engineered truncation in ankyrin and sterile alpha motif (SAM)-containing 3 (ANKS3) leads to symmetric mRNA decay mediated by the Bicc1-interacting Dand5 3′ UTR. AlphaFold structure predictions of protein complexes and their biochemical validation by in vitro reconstitution reveal a novel interaction of the C-terminal coiled coil domain of ANKS3 with Bicc1 that inhibits binding of target mRNAs, depending on the conformation of ANKS3 and its regulation by ANKS6. The dual regulation of RNA binding by mutually opposing structured protein domains in this multivalent protein network emerges as a novel mechanism linking associated laterality defects and possibly other ciliopathies to perturbed dynamics in Bicc1 ribonucleoparticle (RNP) formation.
Non-gonadal somatic piRNA pathways ensure sexual differentiation, larval growth, and wing development in silkworms
Authors: Kiuchi Takashi , Shoji Keisuke , Izumi Natsuko , Tomari Yukihide , Katsuma Susumu
Published: September 2023

PIWI-interacting RNAs (piRNAs) guide PIWI proteins to target transposons in germline cells, thereby suppressing transposon activity to preserve genome integrity in metazoans’ gonadal tissues. Piwi, one of three Drosophila PIWI proteins, is expressed in the nucleus and suppresses transposon activity by forming heterochromatin in an RNA cleavage-independent manner. Recently, Piwi was reported to control cell metabolism in Drosophila fat body, providing an example of piRNAs acting in non-gonadal somatic tissues. However, mutant flies of the other two PIWI proteins, Aubergine (Aub) and Argonaute3 (Ago3), show no apparent phenotype except for infertility, blurring the importance of the piRNA pathway in non-gonadal somatic tissues. The silkworm, Bombyx mori, possesses two PIWI proteins, Siwi (Aub homolog) and BmAgo3 (Ago3 homolog), whereas B. mori does not have a Piwi homolog. Siwi and BmAgo3 are mainly expressed in gonadal tissues and play a role in repressing transposon activity by cleaving transposon RNA in the cytoplasm. Here, we generated Siwi and BmAgo3 loss-of-function mutants of B. mori and found that they both showed delayed larval growth and failed to become adult moths. They also exhibited defects in wing development and sexual differentiation. Transcriptome analysis revealed that loss of somatic piRNA biogenesis pathways results in abnormal expression of not only transposons but also host genes, presumably causing severe growth defects. Our results highlight the roles of non-gonadal somatic piRNAs in B. mori development.
Neuronal expression in Drosophila of an evolutionarily conserved metallophosphodiesterase reveals pleiotropic roles in longevity and odorant response
Authors: Gupta Kriti , Chakrabarti Sveta , Janardan Vishnu , Gogia Nishita , Banerjee Sanghita , Srinivas Swarna , Mahishi Deepthi , Visweswariah Sandhya S.
Published: September 2023

Evolutionarily conserved genes often play critical roles in organismal physiology. Here, we describe multiple roles of a previously uncharacterized Class III metallophosphodiesterase inDrosophila, an ortholog of the MPPED1 and MPPED2 proteins expressed in the mammalian brain. dMpped, the product ofCG16717, hydrolyzed phosphodiester substrates including cAMP and cGMP in a metal-dependent manner.dMppedis expressed during development and in the adult fly. RNA-seq analysis ofdMppedKOflies revealed misregulation of innate immune pathways.dMppedKOflies showed a reduced lifespan, which could be restored inDreddhypomorphs, indicating that excessive production of antimicrobial peptides contributed to reduced longevity. Elevated levels of cAMP and cGMP in the brain ofdMppedKOflies was restored on neuronal expression of dMpped, with a concomitant reduction in levels of antimicrobial peptides and restoration of normal life span. We observed thatdMppedis expressed in the antennal lobe in the fly brain.dMppedKOflies showed defective specific attractant perception and desiccation sensitivity, correlated with the overexpression ofObp28andObp59in knock-out flies. Importantly, neuronal expression of mammalian MPPED2 restored lifespan indMppedKOflies. This is the first description of the pleiotropic roles of an evolutionarily conserved metallophosphodiesterase that may moonlight in diverse signaling pathways in an organism.
Views and experiences of opioid access amongst palliative care providers and public representatives in a low-resource setting: A qualitative interview study
Authors: Clark Joseph , Salins Naveen , Daniel Sunitha , Currow David C. , Jones Lesley , Pearson Mark , Bunton Robin , Mankel Joseph , Braithwaite Christopher , Gilchrist Marianne M. , Johnson Miriam J.
Published: September 2023

Opioids (e.g. morphine) are affordable, effective interventions for cancer-related pain. However, equity of access to this key medication remains a global challenge, particularly in low- and middle-income countries. We aimed to explore views of palliative care providers and public-representatives about opioid analgesia access in two States in India. We conducted a qualitative study using semi-structured interviews. Transcribed audio-recordings were subjected to thematic analysis using a Framework Approach. Palliative care providers and public-representatives were purposively sampled from services reporting consistent opioid availability and prescribing (≥4kg per annum) from Karnataka and Kerala. Twenty participants (doctors (10), nurses (4), pharmacists (2), service managers (2) and public-representatives (2) were interviewed. Three themes were identified: 1) Attitudes and awareness: opioid treatments are perceived as end-of-life (last days/weeks) interventions; fears of addiction and misunderstanding of pain management goals limit access. 2) Expected and unexpected inequities: patients/carers from lower socioeconomic strata accept doctor recommendations if opioids are affordable, more educated patients/families have reservations about opioids, delay access and perceive expensive medicines as better. Non-palliative care specialist doctors have negative entrenched views and require specialist training. 3) Experiential learning–positive experiences can positively alter attitudes (e.g., participants in Kerala report improved attitudes, awareness and understanding influenced by exposure and community awareness, but experience can also reinforce perceptions as end-of-life care. Entrenched negative views are reinforced by poor experiences while positive experiences improve attitudes. To promote access, opioid prescribing must be needs-based rather than prognosis-based. Addressing the lack of training for non-palliative care workforce would help overcome a major barrier.
FIFA football nurse – A task sharing approach in sports and exercise medicine practice in grassroots women’s football in low- and middle- income settings. A study protocol for a cluster randomised controlled trial
Authors: Mkumbuzi Nonhlanhla Sharon , Massey Andrew , Lubega Samuel Kiwanuka , Sorowen Ben , Chisati Enock Madalitso
Published: September 2023

Football (soccer) is a very popular team sport among African women and girls, with player numbers continuing to rise at all levels of the sport. Whereas the participation in football and associated injuries are on the rise, there are not enough sports and exercise medicine (SEM) personnel to attend to these women football players. While Africa may not currently have enough SEM trained medical doctors and/or physiotherapists, it has relatively higher numbers of other healthcare workers; for example, nurses, who lead healthcare services provision from community to tertiary levels. The primary objective of this study will be to compare sports medicine practices; injury prevention behaviours; injury risk parameters; incidence and prevalence of injuries and illnesses in teams with and without a Football Nurse during one competitive season in Malawi’s Women’s football league. This study will be a cluster randomised control trial will recruit 24 teams from the Women’s Football League in Malawi, which will be randomised to either the intervention group or the control group. A cohort of 12 nurses will receive training in basic football medicine; after which they will be attached to a total of 12 women’s football teams (intervention group) during one competitive season. The Football Nurses will be directly report to a physiotherapist or doctor in their district to whom they will refer serious injuries for investigations, or further management. The teams with Football Nurses will be compared to other teams that will not have Football Nurses. We expect to develop a low cost, sustainable and context relevant solution to manage the treatment gap of football injuries/illnesses in underserved communities such as women’s football.

Trial registration number: Pan African Clinical Trial Registry (PACTR202205481965514).
Protective effect of paeoniflorin in diabetic nephropathy: A preclinical systematic review revealing the mechanism of action
Authors: Zhang Xue-Er , Pang Yao-bin , Bo Qu , Hu Shuang-Yuan , Xiang Ju-Yi , Yang Zheng-Ru , Zhang Xiao-Mei , Chen An-Jing , Zeng Jin-Hao , Ma Xiao , Guo Jing
Published: September 2023

Background

Paeoniflorin (PF), the main active glucoside of Paeonia Lactiflora, has many pharmacological activities, such as inhibition of vasodilation, hypoglycemia, and immunomodulation. Although the current evidence has suggested the therapeutic effects of PF on diabetic nephropathy (DN), its potential mechanism of action is still unclear.

Purpose

A systematic review and meta-analysis of the existing literature on paeoniflorin treatment in DN animal models was performed to evaluate the efficacy and mechanism of PF in DN animal models.

Methods

The risk of bias in each study was judged using the CAMARADES 10-item quality checklist with the number of criteria met varying from 4 / 10 to 7 / 10, with an average of 5.44. From inception to July 2022, We searched eight databases. We used the Cochrane Collaboration’s 10-item checklist and RevMan 5.3 software to assess the risk of bias and analyze the data. Three-dimensional dose/time-effect analyses were conducted to examine the dosage/time-response relations between PF and DN.

Results

Nine animal studies were systematically reviewed to evaluate the effectiveness of PF in improving animal models of DN. Meta-analysis data and intergroup comparisons indicated that PF slowed the index of mesangial expansion and tubulointerstitial injury, 24-h urinary protein excretion rate, expression of anti-inflammatory mediators (mRNA of MCP-1, TNF-α, iNOS, and IL-1 β), and expression of immune downstream factors (P-IRAK1, TIRF, P-IRF3, MyD88, and NF-κBp-p65). Furthermore, modeling methods, animal species, treatment duration, thickness of tissue sections during the experiment, and experimental procedures were subjected to subgroup analyses.

Conclusion

The present study demonstrated that the reno-protective effects of PF were associated with its inhibition on macrophage infiltration, reduction of inflammatory mediators, and immunomodulatory effects. In conclusion, PF can effectively slow down the progression of DN and hold promise as a protective drug for the treatment of DN. Due to the low bioavailability of PF, further studies on renal histology in animals are urgently needed. We therefore recommend an active exploration of the dose and therapeutic time frame of PF in the clinic and in animals. Moreover, it is suggested to actively explore methods to improve the bioavailability of PF to expand the application of PF in the clinic.
Diffusion tensor imaging: Influence of segmentation on fiber tracking in the supraspinatus muscle–An inter-operator reliability analysis
Authors: Vetter Sebastian , Köhler Hans-Peter , Hepp Pierre , Steinke Hanno , Schleifenbaum Stefan , Theopold Jan , Kiem Simon , Witt Maren , Henkelmann Jeanette , Roth Christian
Published: September 2023

The ability of muscle to generate force depends on its architecture and health condition. MR-based diffusion tensor imaging of muscle (mDTI) is an innovative approach for showing the fiber arrangement for the whole muscle volume. For accurate calculations of fiber metrics, muscle segmentation prior to tractography is regarded as necessary. Since segmentation is known to be operator dependent, it is important to understand how segmentation affects tractography. The aim of this study was to compare the results of deterministic fiber tracking based on muscle models generated by two independent operators. In addition, this study compares the results with a segmentation-free approach. Fifteen subjects underwent mDTI of the right shoulder. The results showed that mDTI can be successfully applied to complex joints such as the human shoulder. Furthermore, operator segmentation did not influence the results of fiber tracking and fascicle length (FL), fiber volume (FV), fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) showed excellent intraclass correlation estimates (≥ 0.975). As an exploratory approach, the segmentation-free fiber tracking showed significant differences in terms of mean fascicle length. Based on these findings, we conclude that tractography is not sensitive to small deviations in muscle segmentation. Furthermore, it implies that mDTI and automatic segmentation approaches or even a segmentation-free analysis can be considered for evaluation of muscle architecture.
ATP binding cassette transporters and uridine diphosphate glycosyltransferases are ancient protein families that evolved roles in herbicide resistance through exaptation
Authors: Caygill Samuel , Dolan Liam
Published: September 2023

ATP-binding cassette (ABC) transporters actively transport various substances across membranes, while uridine diphosphate (UDP) glycosyltransferases (UGTs) are proteins that catalyse the chemical modification of various organic compounds. Both of these protein superfamilies have been associated with conferring herbicide resistance in weeds. Little is known about the evolutionary history of these protein families in the Archaeplastida. To infer the evolutionary histories of these protein superfamilies, we compared protein sequences collected from 10 species which represent distinct lineages of the Archaeplastida–the lineage including glaucophyte algae, rhodophyte algae, chlorophyte algae and the streptophytes–and generated phylogenetic trees. We show that ABC transporters were present in the last common ancestor of the Archaeplastida which lived 1.6 billion years ago, and the major clades identified in extant plants were already present then. Conversely, we only identified UGTs in members of the streptophyte lineage, which suggests a loss of these proteins in earlier diverging Archaeplastida lineages or arrival of UGTs into a common ancestor of the streptophyte lineage through horizontal gene transfer from a non-Archaeplastida eukaryote lineage. We found that within the streptophyte lineage, most diversification of the UGT protein family occurred in the vascular lineage, with 17 of the 20 clades identified in extant plants present only in vascular plants. Based on our findings, we conclude that ABC transporters and UGTs are ancient protein families which diversified during Archaeplastida evolution, which may have evolved for developmental functions as plants began to occupy new environmental niches and are now being selected to confer resistance to a diverse range of herbicides in weeds.
How has COVID-19 affected the work environment of delivery workers?: An interpretative phenomenological analysis
Authors: Pyo Jeehee , Park Eun Jee , Ock Minsu , Lee Won , Lee Hye Jin , Choi Sungkyoung
Published: September 2023

The COVID-19 pandemic has sparked a rapid worldwide increase in the utilization of delivery services. This study delves into the experiences of delivery workers as one of the activley developed industries during the COVID-19 pandemic in South Korea and sheds light on the effects of the pandemic on their working conditions. Through in-depth interviews with 10 Korean delivery workers, data analysis employed the hermeneutic phenomenology research method developed by Van Manen. The findings indicate a substantial rise in income levels and a positive societal perception of delivery labor post-COVID-19. The pandemic also attracted many new workers to the industry due to low entry barriers and work flexibility. However, challenges persisted as delivery workers grappled with an uncertain legal status and sometimes jeopardized their safety to boost earnings in shorter time frames. The pivotal role played by delivery workers in enhancing communal quality of life and connectivity during the pandemic cannot be overlooked. As we step into a post-COVID-19 era, comprehensive efforts are needed to enhance the working environment for delivery workers globally. Notably, clarifying the relationship between delivery workers and companies within the novel digital labor landscape is essential, alongside establishing institutional frameworks to safeguard workers’ basic rights, including health and safety provisions.
Alcohol and khat dual use among male adults in Ethiopia: A multilevel multinomial analysis
Authors: Tegegne Kirubel Dagnaw , Boke Moges Muluneh , Lakew Asres Zegeye , Gebeyehu Natnael Atnafu , Kassaw Mesfin Wudu
Published: September 2023

Introduction

Substance use has been a long-standing global public health problem with detrimental physical, psychological, social, and economic consequences at individual and societal levels. Large-scale and gender-specific studies on the dual use of alcohol and khat are limited. This study aimed to estimate the prevalence of dual alcohol and khat use and identify associated factors among male adults in Ethiopia.

Methods

The present study used data from the 2016 Ethiopian Demographic and Health Survey (EDHS). Prior to data analysis, the data were weighted to ensure a representative sample and obtain a reliable estimate. Multilevel multinomial logistic regression was used to identify the factors associated with alcohol and khat use. Adjusted Odds Ratios (AOR) with 95% confidence interval and P value ≤ 0.05 in the multivariable model were used to identify significant factors associated with alcohol and khat use.

Results

This study included 12,688 participants, of which (80.29%) were from rural areas. The mean age of participants was 30.92 years old. The prevalence of neither Alcohol nor Khat users were (33.2%); 95% Confidence Interval (CI) (32.4–34.1) only Khat users (22.0%); 95% CI (21.2–22.7), only Alcohol users (35.6%); 95% CI (34.7–36.4), and dual Alcohol and Khat users were (9.0%); 95% CI (8.5–9.5). At the individual level: being in the age group of 15–29 years and 30-49years increases the odds of Khat chewing by AOR (95%CI) 2.27 (1.75, 2.89) and 1.55 (1.16, 2.07) times, respectively. At the community level: males from Amhara 3.49(1.91, 6.42), and Tigray 2.7(1.49, 5.05) regions were more likely to drink alcohol.

Conclusion

The high prevalence of dual alcohol and khat use implies for greater access to evidence-based treatment. Multiple factors are associated with alcohol and khat use at individual and community levels. All male adults would benefit from targeted preventive strategies.
Quantitative morphological transformation of vascular bundles in the culm of moso bamboo (Phyllostachys pubescens)
Authors: Tsuyama Taku , Hamai Kensei , Kijidani Yoshio , Sugiyama Junji
Published: September 2023

Vascular bundles of bamboo are determinants for mechanical properties of bamboo material and for physiological properties of living bamboo. The morphology of vascular bundles reflecting mechanical and physiological functions differs not only within internode tissue but also among different internodes in the culm. Although the distribution of vascular bundle fibers has received much attention, quantitative evaluation of the morphological transformation of vascular bundles associated with spatial distribution patterns has been limited. In this study deep learning models were used to determine quantitative changes in the distribution and morphology of vascular bundles in the culms of moso bamboo (Phyllostachys pubescens). A precise model for extracting vascular bundles from cross-sectional images was constructed using the U-Net model. Analyses of extracted vascular bundles from different internodes showed significant changes in vascular bundle distribution and morphology among internodes. Vascular bundles in lower internodes showed outer relative position and larger area than those in upper internodes. Aspect ratio and eccentricity indicate that vascular bundles in internodes near the base have more elliptical morphology, with a long axis in the radial direction. The variational autoencoder model using extracted vascular bundles enabled simulation of the morphological transformation of vascular bundles along with radial direction. These deep learning models enabled highly accurate quantification of vascular bundle morphologies, and will contribute to a further understanding of bamboo development as well as evaluation of the mechanical and physiological properties of bamboo.
Demographic and psychometric predictors associated with engagement in risk-associated alternative healthcare behaviours
Authors: Garrett Bernie , Caulfield Timothy , Musoke Richard , Murdoch Blake , Tang Xuyan , Lam Joyce S. T.
Published: September 2023

This paper builds on prior work exploring the use of risk-associated alternative healthcare (RAAH) in Canada. RAAH uptake was surveyed to explore the characteristics of adult RAAH users and the value of established psychometric instruments previously used in alternative healthcare studies in predicting RAAH behaviours: the Control Beliefs Inventory (CBI), the Reward Responsiveness Behavioural Activation System (RBAS) scale, the Positive Attitudes to Science (PAS) scale, the Satisfaction with Orthodox Medicine (SOM) scale, and the brief version of the Susceptibility to Persuasion-II (StP-II-B) scale. Findings suggest RAAH is influenced by gender, age, income, education, employment, chronic illness status, and ethnicity. Engagement in some form of RAAH was common (around 40%) and the most common types of RAAH use reported were physical manipulation and herbal/nutritional supplement use. Other higher-risk AH activities (such as use of toxins and physically invasive procedures) were also reported by about 5% of respondents. The StP-II-B and PAS instruments were predictive of the likelihood of engagement in RAAH behaviours, as illustrated by higher risk tolerance, desire for novelty, positive attitude to advertising and social influence, and positive beliefs about science. The CBI, RBAS, and SOM instruments were not predictive overall. However, the CBI and SOM instruments were predictive of engagement with physical manipulative RAAH activities, while the RBAS was predictive of herbal/nutritional RAAH engagement. These findings can help inform health professionals’ understanding of public health-seeking behaviours with respect to risk.
A framework for sample size calculations in longitudinal surveys to measure net and gross changes
Authors: Elkasabi Mahmoud , Suzer-Gurtekin Z. Tuba , Chen Yuxuan
Published: September 2023

In longitudinal surveys, repeated measurements are collected from the same sample units over time to measure gross change (i.e., change at the level of individual sample members). Longitudinal samples are sometimes supplemented by fresh sample to measure net change (i.e., change at the aggregate level). That is, in each measurement wave, while one part of the sample is newly recruited (fresh), another part overlaps with previously interviewed sample (repeated interviews). Many aspects of survey design of longitudinal surveys have been studied extensively, such as definition of target population, sample design, survey weighting, intervals between interviews, nonresponse, and panel attrition. Although the impact of the overlap between samples on the statistical power has been studied, sample size determination lacks a formulation that takes account of these factors in longitudinal surveys that aim to measure net and gross changes simultaneously. In this study, we propose a framework for sample size calculation to measure net and gross changes in estimated means or proportions concurrently in longitudinal surveys. We present a framework to compute panel and fresh sample sizes for varying levels of net and gross change. Finally, we illustrate the framework using nchange, an R package we developed to execute the algorithm of the proposed framework. The framework and the R package will support researchers to determine sample sizes targeting specific power of analysis with respect to measuring net and gross changes in rotating- or split-panel surveys.
Evaluation of the operation status of the residential land market in Beijing-Tianjin-Hebei region of China and its spatiotemporal pattern characteristics
Authors: Chen Xin , Li Can , Li Huixia , Ge Jingfeng , Wang Wengang , An Pengfei
Published: September 2023

Exploring the operation status and patterns of urban land markets is an important theoretical and practical topic for promoting coordinated socio-economic development. In this study, the operation status of the residential land market in the Beijing-Tianjin-Hebei region and the characteristics of its pattern were analyzed using the composite index method and the 3σ rule of the normal distribution and taking the 174 counties in Beijing, Tianjin, and Hebei, China, as the research objects. The results show that ① Beijing, Tianjin, Langfang, Zhangjiakou, and Baoding residential land market state composite indexes are all in the middle to upper levels in the Beijing-Tianjin-Hebei city cluster, while Qinhuangdao, Handan, and Chengde residential land market state composite indexes are generally low. The harmony between the residential land price and national economy, the market supply and demand balance, and the structural balance may become the main factors affecting the healthy development of the residential land market in Beijing and Tianjin. ② The proportion of counties with "healthy" residential land market in all dimensions and overall market status reached over 64%, and the residential land market in the Beijing-Tianjin-Hebei region is running well. The rapid increase in residential land prices from 2016 to 2020 was an important driver of the increased heat in the residential land market across the region. ③ The residential land market in the counties around Beijing and Tianjin is significantly hotter than in other regions, and there is an obvious polarization effect in the operation state of the residential land market in the Beijing-Tianjin region. The residential land market is generally cold in the counties in the southern and northeastern parts of the region and other peripheral areas, and there is a risk of marginalization in the development of the residential land market in the counties in the peripheral areas. ④ Both the hot and cold residential land market states exhibit spatial clustering characteristics. Most of the clusters are not consistent with the municipal administrative boundaries, and the states of the residential land market in neighboring counties are very similar.
Adaptation to life after sport for retired athletes: A scoping review of existing reviews and programs
Authors: Voorheis Paula , Silver Michelle , Consonni Josie
Published: September 2023

Retirement from sport is a life transition that has significant implications for athletes’ physical and mental health, as well as their social and professional development. Although extensive work has been done to review the retirement experiences of athletes, relatively less work has been done to examine and reflect on this expansive body of literature with a pragmatic aim of deciding what needs to happen to better support retiring athletes. This study used scoping review methodology to review current academic reviews, gray literature articles, and support programs on athletic retirement. This review followed the Joanna Briggs Institute reviewer’s manual guide on scoping reviews and adhered to the PRISMA-ScR checklist. Academic articles were identified from PubMed, Embase, Web of Science and Scopus. Gray literature articles and support programs were identified using advanced Google searches. This study identified 23 academic reviews, 44 gray literature articles, and 15 support programs. Generally, the results suggest that athletic retirement encompasses a drastic shift in identity, a loss of social networks, a lack of career ambitions, and potential risks to physical and mental health. While there was a gap in the academic literature regarding practical strategies to support retiring athletes, the gray literature suggests many creative ideas. Stepwise programming may be beneficial to help athletes: (a) make sense of their athletic experience and see retirement as an ongoing process; (b) develop a well-rounded sense of self identity and understand how to apply their unique skills and strengths in new ways; (3) gain control over their retirement transition by establishing a clear plan and adjusting to new routines and opportunities; and (4) normalize the transition experience by “living in the next” and building confidence in new life directions. Future research may benefit from developing and evaluating more programming to support athletes through the retirement transition.
Prediction of respiratory failure risk in patients with pneumonia in the ICU using ensemble learning models
Authors: Lyu Guanqi , Nakayama Masaharu
Published: September 2023

The aim of this study was to develop early prediction models for respiratory failure risk in patients with severe pneumonia using four ensemble learning algorithms: LightGBM, XGBoost, CatBoost, and random forest, and to compare the predictive performance of each model. In this study, we used the eICU Collaborative Research Database (eICU-CRD) for sample extraction, built a respiratory failure risk prediction model for patients with severe pneumonia based on four ensemble learning algorithms, and developed compact models corresponding to the four complete models to improve clinical practicality. The average area under receiver operating curve (AUROC) of the models on the test sets after ten random divisions of the dataset and the average accuracy at the best threshold were used as the evaluation metrics of the model performance. Finally, feature importance and Shapley additive explanation values were introduced to improve the interpretability of the model. A total of 1676 patients with pneumonia were analyzed in this study, of whom 297 developed respiratory failure one hour after admission to the intensive care unit (ICU). Both complete and compact CatBoost models had the highest average AUROC (0.858 and 0.857, respectively). The average accuracies at the best threshold were 75.19% and 77.33%, respectively. According to the feature importance bars and summary plot of the predictor variables, activetx (indicates whether the patient received active treatment), standard deviation of prothrombin time-international normalized ratio, Glasgow Coma Scale verbal score, age, and minimum oxygen saturation and respiratory rate were important. Compared with other ensemble learning models, the complete and compact CatBoost models have significantly higher average area under the curve values on the 10 randomly divided test sets. Additionally, the standard deviation (SD) of the compact CatBoost model is relatively small (SD:0.050), indicating that the performance of the compact CatBoost model is stable among these four ensemble learning models. The machine learning predictive models built in this study will help in early prediction and intervention of respiratory failure risk in patients with pneumonia in the ICU.
Temporal properties of the speed-accuracy trade-off for arm-pointing movements in various directions around the body
Authors: Okuuchi Soma , Tani Keisuke , Kushiro Keisuke
Published: September 2023

Human body movements are based on the intrinsic trade-off between speed and accuracy. Fitts’s law (1954) shows that the time required for movement is represented by a simple logarithmic equation and is applicable to a variety of movements. However, few studies have determined the role of the direction in modulating the performance of upper limb movements and the effects of the interactions between direction and distance and between direction and target size. This study examined the variations in temporal properties of the speed-accuracy trade-off in arm-pointing movements that directly manipulate objects according to the direction, distance, and target size. Participants performed pointing movements to the targets with 3 different sizes presented at 15 locations (5 directions and 3 distances) on a horizontal plane. Movement time (MT) for each trial in each condition was obtained. Subsequently, Mackenzie’s model (1992), MT = a + b log2(D/W +1), where D and W represent the distance and width of the target, respectively, was fitted. The slope factor b, a fitted parameter in the equation, was calculated and evaluated according to the changes in the direction, distance, and target size. The results showed that MTs exhibited anisotropy in the hemifield, being the smallest in the right-forward direction. Additionally, the slope factor b, as a function of distance, was smaller in the rightward direction than in the forward and left-forward directions. These results suggest that the degree of difficulty of upper limb movements expands heterogeneously in various directions around the body.
Finite element simulation study on vertical bearing characteristics of single pile with ram-compacted bearing sphere
Authors: Bai Lichao , Gong Shangwei , Xu Lina , Bai Xiaohong , Huang Zhanfang
Published: September 2023

The pile with ram-compacted bearing sphere (PRBS)is a kind of special-shaped pile, the calculation formula of single pile bearing capacity stipulated in Chinese Standards JGJ/T 135–2018 is relatively simple, and the factors considered are not comprehensive enough. This article uses the finite element simulation software ABAQUS to simulate and calculate the compressive bearing characteristics of PRBS, and studies the changes in the vertical bearing characteristics of PRBS under different factors and working conditions (different pile lengths, pile diameters, and the diameters of ram-compacted bearing sphere (RBS)). The calculation results indicate that the PRBS still has a large axial force near the enlarged end of the pile bottom, and the RBS bears a large load. The vertical bearing capacity of the PRBS is mainly provided by the RBS, but the pile side friction still has a certain degree of influence on its bearing capacity. The maximum ratio of pile side frictional resistance to applied load can reach 18.41%. Compared with the ordinary pile, the bearing capacity of the PRBS is significantly improved. The ultimate bearing capacity of the PRBS with the RBS diameter of 1m is more than 5 times that of the ordinary pile under the same condition. Pile diameter has little influence on the bearing capacity of PRBS, while the change of RBS diameter has great influence on the bearing capacity of single pile. However, when the RBS diameter is too large, it is easy to cause the uplift of surrounding soil in the construction process and affect surrounding piles. Therefore, it is suggested that the optimal RBS diameter should be 800mm~1200mm. This study provides reference suggestions for the study of piles with ram-compacted bearing sphere.