bluuebunny/crossref_metadata_2025 huggingface dataset:
Determinants of Purchase Intention for Green Consumer Durables: Investigating the Moderating Role of Price Sensitivity
Authors: Riyaz Mehvish , Jan Anisa , Khan Danish , Zahoor Adil
Published: September 2024

Drawing upon the theory of planned behavior, the present study investigates the antecedents (perceived value, media exposure, and environmental knowledge) of customer intention toward purchasing green durables. Secondarily, this study also examines whether the driver effect of the precursors of customers’ sustainable purchase intention varies across different levels of their price sensitivity. A mall-intercept survey method was used to acquire data from 261 respondents from India’s National Capital Region, and the relationships were tested using PLS-SEM. The findings reveal that perceived value, media exposure, and environmental knowledge positively impact customer buying intention of green durables. Also, price sensitivity negatively moderates the relationship between media exposure and purchase intention. These results afford critical insights to marketers and policymakers regarding the driving factors of customer intention to purchase eco-friendly durables.
From Risk to Reward: Understanding the Influence of Generation Z and Personality Factors on Sustainable Entrepreneurial Behaviour
Authors: Lopes João M. , Gomes Sofia , Trancoso Tiago
Published: September 2024

Entrepreneurial intent has transformed over the last few decades to respond to current environmental, societal and economic challenges. An essential role in this transformation has been bequeathed to Generation Z. This study aims to evaluate the influence of Generation Z personality traits measured by internal locus control, perceived creativity (PC), proactive personality (PP) and sustainable perceived behavioural control (SPBC) on sustainable entrepreneurial intention (SEI) when mediated by Generation Z’s perception of risk. The sample for this study was collected through a data collection instrument in which 505 young people from Portuguese Generation Z participated. A quantitative methodology was applied through the Partial Least Square method. The results show that the personality traits, PC, PP and sustainable perceived control behaviour of Generation Z positively influence their risk perception (RP) and SEI. In turn, RP positively influences the SEI of these young people. No statistically significant relationship was found between the internal locus control of Generation Z youth and RP or SEI. This study is key to expanding identity theory to the context of sustainable entrepreneurship among Generation Z youth, highlighting how RP shapes their entrepreneurial practices. By contributing to the still scarce literature on generational cohorts in the field of entrepreneurial activity, the study offers a valuable empirical analysis of the relationship between personality traits and entrepreneurial intention. In addition, it deepens understanding of the emerging concept of sustainable entrepreneurship, providing important insights for promoting environmentally responsible business practices among younger generations.
Evaluation of Tibiofemoral Contact Mechanics After a Novel Hybrid Procedure for Femoral Osteochondral Defect Repairs With a Subchondral Implant and Dermal Matrix
Authors: Hung Victor T. , Dee Derek T. , McGarry Michelle H. , Lee Thay Q.
Published: September 2024

Background:

There is a lack of procedures that adequately address the subchondral bone structure and function for reconstructing osteochondral defects in the femoral condyles.

Purpose:

To biomechanically evaluate the tibiofemoral joint contact characteristics before and after reconstruction of femoral condylar osteochondral defects using a novel hybrid reconstructive procedure, which was hypothesized to restore the contact characteristics to the intact condition.

Study Design:

Controlled laboratory study.

Methods:

Tibiofemoral contact areas, contact forces, and mean contact pressures were measured in 8 cadaveric knees (mean age 52 ± 11 years; 6 women, 2 men) using a custom testing system and pressure mapping sensors. Five conditions were tested for each condyle: intact, 8-mm defect, 8-mm repair, 10-mm defect, and 10-mm repair. Medial femoral condylar defects were evaluated at 30° of knee flexion and lateral condylar defects were evaluated at 60° of knee flexion, with compressive loads of 50, 100, and 150 N. The defects were reconstructed with a titanium fenestrated threaded implant countersunk in the subchondral bone and an acellular dermal matrix allograft. Repeated-measures analysis of variance with Bonferroni correction for multiple comparisons was used to compare the results between the 5 testing conditions at each load.

Results:

Medial condylar defects significantly increased mean contact pressure on the lateral side ( P < .042), which was restored to the intact levels with repair. The lateral condylar defect decreased the mean contact pressure laterally while increasing the mean pressure medially. The lateral and medial mean contact pressures were restored to intact levels with the 8-mm lateral condylar defect repair. The medial mean contact pressure was restored to intact levels with the 10-mm lateral condylar defect repair. The lateral mean contact pressure decreased compared with the intact state with the lateral condylar 10-mm defect repair.

Conclusion:

Tibiofemoral joint contact pressure was restored to the intact condition after reconstruction of osteochondral defects with dermal allograft matrix and subchondral implants for the repair of both 8- and 10-mm lateral condylar defects as well as 8-mm medial condylar defects but not completely for 10-mm medial condylar defects.

Clinical Relevance:

The novel hybrid procedure for osteochondral defect repair restored tibiofemoral joint contact characteristics to normal in a cadaveric model.
Prevalence of Co-Infections and Pathogens in Hospitalized Children with Acute Respiratory Infections: A Comparative Analysis Between SARS-CoV-2 and Non-SARS-CoV-2 Cases
Authors: Moolasart Visal , Nitiyanontakij Ravee , Samadchai Srisuda , Srisopha Somkid , Atiburanakul Priyanut , Chottanapund Suthat , Uttayamakul Sumonmal
Published: September 2024

Objectives. We aimed to compare the prevalence of co-infections, pathogens, and factors associated with SARS-CoV-2 acute respiratory infection (ARI) and non-SARS-CoV-2 ARI, among hospitalized children. Methods. We conducted an observational cross-sectional study of hospitalized children <15 years with ARI, and lasting respiratory symptoms <14 days, using polymerase chain reaction on nasopharyngeal specimens. Results. Of the 184 children with ARI analyzed, 122 were infected with SARS-CoV-2 and 62 were not. SARS-CoV-2 ARI had a significantly lower rate of co-infection than non-SARS-CoV-2 ARI (2.5% vs14.5%, P = .003). SARS-CoV-2 ARI children were significantly associated with a less empirical antibiotics (aOR = 0.09, CI = 0.03-0.21; P = .000), more pneumonia (aOR = 5.15, CI = 1.77-14.95; P = .003), and more abnormal chest X-ray (aOR = 2.81, CI = 1.38-5.71; P = .004). Conclusions. Although SARS-CoV-2 ARI in hospitalized children was associated with pneumonia and abnormal chest x-rays, empirical antibiotics may not be necessary for treating mild to moderate cases.
Teachers’ Evolving Knowledge Base for Teaching Sustainable Development in the Geography Classroom
Authors: Huh Sojung , Jo Injeong
Published: September 2024

With the increasing importance of teaching sustainable development (SD) in cultivating knowledgeable and responsible citizens who actively contribute to the environment, economy, and society, there is a pressing need for expertise within the teaching profession, particularly among social studies educators. This research aims to explore the professional knowledge, skills, and wisdom of social studies teachers in effectively integrating SD into the current geography curriculum. Seven high school geography teachers participated in this multiple case study, revealing the distinct knowledge base components necessary for teaching SD in the geography classrooms. Findings reveals how geography teachers utilize and evolve their professional knowledge base and the interplay between these components through the transformations in teachers’ knowledge bases before, during, and after professional development.
Meaning-Making Through Dialogic Classroom Discourse in History Classes: Multi-Perspective Case Studies From a Teacher Professional Development Program
Authors: Moser Miriam , Zimmermann Matthias
Published: September 2024

This article examines the characteristics of meaning-making during classroom discourse using data from a study regarding a yearlong teacher professional development (TPD) program intended to promote dialogic discourse in whole-class practice. The in-depth, video-based case analyses of two whole-class discussions in history classes (two classes/teachers, N = 46 students) at the end of the TPD integrate multi-semiotic and content-bound perspectives. The analyses show how the students adopt an active role in shaping the dialog and contribute to the direction of the discourse, while both teachers assume a moderating stance. Concurrently, the findings highlight the inherent tension teachers face while ensuring student participation and compliance with disciplinary norms. In addition, the results reveal new student roles and asymmetries due to altered responsibilities in student-owned classroom discourse, which are particularly elucidated through nonverbal interactions. This contributes to existing research by highlighting novel, critical elements for consideration in TPD.
Post-COVID job Stressors and Their Predictive Role on Mental Health: A Cross-Sectional Analysis Between Physicians and Nurses
Authors: Fernández-Martínez Selene , Armas-Landaeta Carilene , Pérez-Aranda Adrián , Guzmán-Parra José , Monreal-Bartolomé Alicia , Carbonell-Aranda Vera , García-Campayo Javier , López-del-Hoyo Yolanda
Published: September 2024

Introduction

Health care providers face heightened stress and increased rates of anxiety and depression post-COVID-19. The pandemic, officially declared over in May 2023, continues to impact their wellbeing significantly, with ongoing mental health monitoring and tailored interventions crucial for support.

Objectives

The aim of this study was to describe the frequency of job stressors in a sample of Spanish health care providers post-COVID and to explore potential differences between physicians and nurses, hypothesizing that while both professional categories could experience similar job stressors, some of them could have a differential impact on the mental health of each subgroup.

Methods

This cross-sectional substudy is part of the MINDxYOU project. The data were collected from 191 health care providers from two regions in Spain. Participants completed the UNIPSICO test battery, used to assess job stressors, and questionnaires to evaluate perceived stress, depressive symptomatology, anxiety, and resilience. Descriptive analyses, bivariate correlations, and linear regression models were performed to compare the two professions that were the most representative of our sample: physicians (n = 82) and nurses (n = 54).

Results

The most frequent job stressors were workload, lack of positive feedback, and inequity in social interactions. Physicians reported worse outcomes in terms of workload, autonomy, role conflicts, inequity in social interactions, and work-family balance compared to nurses. Mobbing, despite not being very frequent, significantly predicted different mental health outcomes for both physicians and nurses. Inequity in social interactions and job satisfaction were significant predictors of physicians’ mental health, while role ambiguity, interpersonal conflicts, and career turnover intentions predicted nurses’ mental health.

Conclusion

As hypothesized, our findings highlight that certain job stressors (i.e., inequity in social interactions, conflicts in the workplace) might be affecting physicians’ and nurses’ mental health differently. Therefore, effective strategies addressing each subgroup's specific stressors would be necessary to prevent the development of burnout syndrome and other serious mental health conditions associated with occupational stress. These strategies would imply organizational changes in most cases.
Association between angiographic and clinical outcomes after STA-MCA bypass in adult moyamoya disease
Authors: Kuang Guicheng , Ji Hang , Zheng Jixuan , Li Xinchen , Luo Kejin , Hu Yajun , Zhang Zheyuan , Sun Haogeng
Published: September 2024

Background and Purpose:

As an angiographic outcome, postoperative collateral formation (PCF) is commonly used to evaluate the effect of STA-MCA bypass in moyamoya disease (MMD), but whether it can reliably reflect clinical outcomes is still unclear. We investigated the association between PCF and clinical outcomes in adult MMD.

Methods:

All STA-MCA bypass procedures performed from January 2013 to December 2019 were screened in this prospective cohort study. Patients who acquired presurgical and follow-up catheter angiography were included. The clinical outcomes consisted of symptom improvement and recurrent cerebrovascular events. Logistic and Cox regression and Kaplan–Meier analyses were performed to explore the association between PCF and clinical outcomes.

Results:

Of 165 included symptomatic hemispheres of 154 patients, 104 (63.0%) and 61 (37.0%) had good and poor PCF, respectively. The hemispheres with good PCF were younger ( p = 0.004) and had a higher incidence of hemodynamic dysfunction on admission ( p < 0.001) than those with poor PCF. Multivariate logistic regression analysis showed that the good PCF (odd ratio, 28.96; 95% confidence interval (CI), 9.12–91.98; p < 0.001) was associated with a higher incidence of symptom improvement. Multivariate Cox regression analysis showed that the poor PCF (hazard ratio, 3.77; 95% CI, 1.31–10.84; p = 0.014) was associated with a higher incidence of recurrent cerebrovascular events. In the hemorrhagic-onset hemispheres, good PCF group had a higher incidence of symptom improvement ( p < 0.001) and a longer hemorrhage-free time ( p = 0.031). In the ischemic-onset hemispheres, good PCF group also had a higher incidence of symptom improvement ( p < 0.001) and a longer ischemia-free time ( p = 0.028).

Conclusions:

As a angiographic outcome, collateral formation is a qualified surrogate measure for clinical outcomes after STA-MCA bypass in adult MMD.
Towards a more realistic estimation of urban land take by combining cadastral parcels and building footprints
Authors: Lagarias Apostolos , Stathakis Demetris
Published: September 2024

Despite its importance as a research issue, a widely accepted methodology of estimating land take resulting from urbanization has not yet been reached. Accurate geospatial datasets are currently available at a European and global level; however, different methods of quantifying urban land take could lead to diverse outputs, potentially resulting in underestimation. This can be alarming as encroaching urban sprawl is emerging as a major environmental challenge by destroying natural habitats, consuming productive agricultural land, and contributing to climate change by increasing energy demands. To address this knowledge gap, we propose an estimation of urban land take that combines cadastral parcels and building footprints. Land parcels can be considered as a suitable minimum mapping unit as they are directly related to the spatial level where economic decisions on land use conversion are made. The proposed geospatial method is compared to methods that depend on datasets of High Resolution Layer Imperviousness, Global Building Footprints (alone), Corine Land Cover, Urban Atlas, and Global Human Settlement Layer. The method is exemplified in case studies in Greece, specifically: (a) two islands of the South Aegean Region (Mykonos and Thera), that are heavily impacted by tourism development and sprawl and (b) a peri-urban zone (Thermaikos-Michaniona) within the metropolitan area of Thessaloniki, impacted by intense suburbanization. Results show that urban land consumes important shares of available land since the mid-20th century, this fact highlighting the dynamic encroachment of urban development. Calculation shows that other methods could underestimate urbanized areas by up to 80%–90%. In the discussion section, the advantages of shifting the focus from the pixel to the parcel are further justified, while explicit links to spatial planning policies for sprawl containment are drawn. Such policies could be informed by more realistic estimations of urban land take, in order to proceed with strategic and regulatory measures to support the ‘no net land take’ policy of Europe.
Prospects of Artificial Intelligence in the Annihilation of Caste
Authors: Sinha Kunal
Published: September 2024

The masquerading effect of caste has engulfed the social structure in such a way that the myth associated with it has perked up in the ideas of existence, making it a reality regulating day-to-day affairs of interaction. Most of the time, it is considered a functional prerequisite. The stratification associated with it has conformity emanating from the acceptance of the identity, which is not evading even after migrating to foreign countries to participate and be part of the capitalist mode of production. Artificial Intelligence (AI) is a creation of the human mind. Caste is also a creation of the human mind. Technology has always paved the way for the betterment of society if used properly. Caste practices have always divided society and contaminated the public sphere with divisive manifestations of their stronghold in influencing social processes and policies. Annihilation of caste was the published work of Dr B. R. Ambedkar in the year 1936, and still the content and the context are seen in society.

In the backdrop of this, the article engages with the role (if any) of AI in mitigating the divisions in society. The readers are already aware of the repercussions of the caste system since time immemorial. The diffusion of technology has always been trying to be inclusive, depending on the socio-economic aspect of any society. Industrialization along with the Information and Communication Technology (ICT) revolution has rendered several avenues and opportunities for the so-called lower caste people to come forward and amalgamate themselves with the so-called upper caste people in the socio- economic process. The article discusses the prospect of the annihilation of caste by the influence of AI. It also engages in discussing caste as a main component of individual and community identity, which has become immune to any form of change in society. The article is based on available secondary sources.
Early Presentation of Successive Acute Retinal Necrosis Decades After Initial Infection
Authors: Le Hao-Tinh , Kesav Natasha , Mehra Ankur , Soliman Mohamed , Sobol Warren
Published: September 2024

Purpose: To describe the early presentation of successive acute retinal necrosis (ARN) decades after the initial infection. Methods: A single case and its findings were analyzed. Results: A 62-year-old man with a remote history of left-sided ARN presented for evaluation of right-sided blurry vision. An examination showed 1+ anterior chamber cells and mild vitritis with multiple small patches of white retinitis. The lesions progressed despite treatment with oral antivirals, eventually requiring multiple doses of intravitreal antiviral agents and hospitalization for intravenous antiviral therapy. Despite a characteristic clinical picture consistent with ARN, multiple aqueous samples tested negative for viral etiologic agents. Conclusions: ARN is a rapidly progressive disease, and the diagnosis is clinical. Our patient was treated aggressively with antiviral therapy on the basis of the clinical picture without confirmatory testing, which remained negative. The lesions responded well to treatment and 20/25 visual acuity was maintained. Regardless of confirmatory testing, timely treatment is critical in cases of suspected ARN.
DIBS*: Crafting a Treasured Niche
Authors: Kaicker Nidhi , Bathla Arushi
Published: September 2024

In January 2022, Siddharth Pande, the founder and owner of DIBS*, a new creative branding studio providing design solutions based in Delhi, was trying to identify an appropriate strategic position for his business in an overcrowded market. Digital spaces have turned business outcomes significantly, especially after the outbreak of the COVID-19 pandemic and the resultant mobility restrictions. Digital agencies experienced plenty of new opportunities as all traditional and new-age businesses were competing to improve their online presence and humanize their brands to connect with their customers. This also gave birth to a plethora of digital brand consulting agencies which offered differentiated services at varying price points. In the design industry that relied on a star system where agencies struggled to make any headway, how could DIBS* craft a treasured niche?
In-group Identification and In-person Activities as Mediators of the Association Between Social Motivation and Psychological Well-being in the Kink Community
Authors: Johnson Jessica R. , Brooks Thomas R. , Hebert Milo , Reysen Stephen
Published: September 2024

The importance of social interaction on well-being has been investigated in a variety of social psychological domains (e.g., homelessness, addiction, and immigration); however, little research has been conducted on the associations between social motivation, community, and well-being within BDSM/kink practitioners. Previous literature has found that feelings of in-group inclusion and attending events predicted well-being in other sexual minority communities; therefore, the current study examines the association between social motivation, in-group inclusion, attending events, and well-being within the BDSM/kink community. A mediational model was tested, and it was found that social motivation significantly predicted well-being through both in-group inclusion and attending events. Additionally, beyond the serial mediation model, both identification with the kink community and attending events were significant mediators on their own. Participation in a BDSM community constitutes a large part of kink for many individuals, meaning that feelings of in-group inclusion and attending community events are likely vital for increasing and maintaining well-being. Marginalized communities often find solace, comfort, and acceptance through community, highlighting the importance of socialization for health and well-being. The study concludes with a discussion on implications, future directions, and the value of community in BDSM/kink communities.
Poroid Neoplasms: A Clinicopathological Study of 13 Cases
Authors: Efared Boubacar , Boubacar Idrissa , Ousmane Kadre Kadre Alio , Abani Bako Aïchatou Balaraba , Boureima Habiba Salifou , Amadou Soumaila , Nouhou Hassan
Published: September 2024

Introduction:

Poroid neoplasms (PN) are a heterogeneous group of tumors deriving from sweat glands and folliculo-sebaceous units. Their histological classification and clinical features are challenging. Our aim was to report clinicopathological features of poroid neoplasms.

Methods:

It is a retrospective study including all cases of poroid neoplasms registered at our Pathology laboratory of Niamey National Hospital (February 2020-February 2024).

Results:

We registered 13 cases of benign poroid neoplasms: 10 classic poromas (CP) (76.9%), 2 poroid hidradenomas (PH) (15.4%) and 1 dermal duct tumor (DDT) (7.7%). Nine cases (69.2%) had preoperative clinical diagnosis of malignancy. The mean age was 41.1 years (range of 12-70 years) with a slight female predominance. Only 4/13 cases (30.8%) had classical palmoplantar locations. The tumors mean size was 3.7 cm (range of 0.4-8 cm). Clear cells were present in 7 cases (53.8%), apocrine ductal differentiation (mixed or pure) in 6 cases (46.2%), keratin horns in 2 cases (15.4%), squamous eddies in 6 cases (46.2%), melanin pigments in 1 case (7.7%) and sebaceous differentiation in 2 cases (15.4%).

Conclusions:

Unlike what is classically reported, our study shows that apocrine ductal differentiation, younger age and non-palmoplantar locations are common in poroid neoplasms.
Complexity of Platelet-Rich Plasma: Mechanism of Action, Growth Factor Utilization and Variation in Preparation
Authors: Pineda-Cortel Maria Ruth , Suarez Consuelo , Cabrera Jan-Tyrone , Daya Minerva , Bonifacio Rinnel Brenan L. , Vergara Renz Cleve , Dacanay Aleth Therese L. , Villavieja Adrian
Published: September 2024

Platelet-rich plasma (PRP) is an autologous blood-derived product utilized nowadays as a treatment for various non-hemostatic, orthopedic, and muscular injuries. Although the exact mechanism of PRP use and effectivity is not yet fully understood, PRP applications are extensively developing and expanding. PRP, as the name implies, contains mostly platelets; thus, platelets are the main players in this therapeutic management for numerous tissue disorders and conditions. Platelets are known to facilitate wound healing and tissue repair through the various growth factors present in their granules. The growth factors in platelets also act on cells found in tissues other than those involved in wound repair, resulting in an increased interest in PRP use as a regenerative therapy for various disorders. In this paper, we discussed platelets and its morphology, and the various growth factors present within the platelet granules. The effects of these growth factors on tissue recovery are highlighted. PRP components, preparation considerations and classifications are presented here to showcase PRP differences and complexity.
Correlation of Velopharyngeal Score in Nasoendoscopy with Perceptual Speech Intelligibility of Patients with Cleft Palate
Authors: Olatunbosun Adamson Olawale , Adeola Adekunle Adegbayi , Oluwanifemi Ayelomi , Adejoke Babatunde , Olutayo James , Lanre Adeyemo Wasiu , Olugbenga Ogunlewe Mobolanle
Published: September 2024

Background and Objective: One of the challenges patients with cleft palate face is the production of intelligible speech. Though instrumental assessment of velopharyngeal function is required, there is a need to correlate the results obtained with speech outcome. The objective of this study is to correlate the Golding-Kushner scale scoring system for velopharyngeal defects as observed on nasoendoscopy with patients’ speech intelligibility. Method: The design is an observational cross-sectional study conducted from December 2022 to May 2023. This study was carried out at the orofacial cleft clinic of a tertiary hospital. Participants: The study included English-speaking patients with cleft palate who had palatorrhaphy done at least 6 months before recruitment. Intervention: Speech intelligibility was measured using a simple analog scale that ranged from 0 to 5 (0—worst speech intelligibility possible, 5—best speech intelligibility). The Golding-Kushner scale is used to measure gap size (defect) in nasoendoscopy. Main outcome measures: The primary outcome is to correlate the score of speech intelligibility with the Golding-Kushner score during nasoendoscopy. Results: A total of 40 people participated in the study, with a median age of 11 years (IQR: 6.25-21.75 years). There is a moderately negative correlation between velopharyngeal gap size and speech intelligibility (correlation coefficient = −0.6, P < .01). Only the size of the size of the gap is a significant predictor of speech intelligibility after cleft palate repair. Conclusion: There is a significant, moderate correlation between velopharyngeal gap size and speech intelligibility.
Going ‘cold turkey’: Oil addiction and ‘traumatic’ decarbonization in fragile fossil fuel producers
Authors: Sarkar Aditya , de Waal Alex
Published: September 2024

Decarbonization, or the replacement of fossil fuels by renewables or ‘cleaner’ forms of energy, is an essential response to global warming. A gap in the debate on decarbonization is its implications for fragile fossil fuel-producing states (FFFPs). Unable to implement strategies for planned decarbonization, FFFPs face the prospect of rapid, unmanaged ‘traumatic’ decarbonization. This paper examines the political economy of this phenomenon drawing on six countries that have experienced dramatic losses in carbon revenues in the recent past: Ecuador, Iraq, Nigeria, South Sudan, Sudan and Venezuela. It also draws on two thematic papers – on peace-making during oil shocks and a review of the literature on energy transition in fragile states. The paper finds that in decarbonizing FFFPs, the rules of the political game tend to be ‘sticky’ and elites react to the loss of oil revenues by looking for alternate sources of rent and turning to coercion. Political settlements including peace agreements are structured around the allocation of oil rents to elites and their future viability is in question. We find only modest evidence for sustainable and democratic paths away from a carbon-based political settlement, despite the efforts of civic movements.
Implementation and Evaluation of APOTECAchemo in a Community Cancer Center: A Comparative Study of Robotic Versus Manual Antineoplastic Preparation
Authors: Cho Han Na , Wells Lyn , Halford Zachery
Published: September 2024

Background: The ever-increasing complexity and demand for antineoplastic therapy necessitates innovative solutions to improve the accuracy and safety of drug preparation. Objective: To evaluate the utilization of an advanced robotic chemotherapy drug compounding system (APOTECAchemo) at a Community Cancer Center (CCC), examining accuracy, efficiency, and staff perceptions. Methods: This single-center, retrospective study evaluated the preparation of 7 intravenous (IV) antineoplastics at a CCC over a 1-year period. We compared manual methods with the APOTECAchemo system. The primary measure of accuracy was the absolute drug error percentage, with a comparison of pass and fail rates. Secondary endpoints included the overall use of APOTECAchemo for all IV antineoplastic preparations and average preparation times. An end-user satisfaction survey gathered feedback from pharmacists and pharmacy technicians. Results: A total of 8210 doses were prepared at the CCC, with 52.1% compounded by APOTECAchemo and 47.9% manually. Of these, the CCC prepared 5526 doses of the 7 routinely compounded antineoplastics. APOTECAchemo prepared 3851 (69.7%) doses, while manual compounding accounted for 1675 (30.3%) doses. The average absolute drug error was 1.44% (95% CI, 1.35-1.53) with robot compounding versus 1.17% (95% CI, 1.03-1.32) with manual ( P < 0.001). The overall failure rate was 0.72%. There were 25 failed doses (0.45%), with 8 (0.2%) failures attributed to APOTECAchemo and 17 (1%) to manual compounding ( P < 0.001). The average dose preparation time was longer with APOTECAchemo compared with manual methods. The end-user satisfaction survey indicated a positive reception toward APOTECAchemo. Conclusions: Our study demonstrates the successful implementation, extensive utilization, and high accuracy of both APOTECAchemo and manual compounding methods in the preparation of routinely administered antineoplastics at a CCC.
Practicing Collaborative Teaching With Care: A Literature Review
Authors: Bingham Heidi H.
Published: September 2024

Collaborative teaching models provide support to music teachers, easing isolation and enhancing professional development, which fosters innovative teaching and professional fulfillment. Researchers have found that these benefits occur when educators have positive attitudes about collaborative teaching and choose to develop strong collaborative partnerships. However, music educators prepared to teach in isolation may not understand how to implement collaborative teaching or successfully build a collaborative partnership. Because strong teacher-to-teacher relationships are essential for collaborative teaching to be beneficial, in this literature review I explore music education research on collaborative teaching through Noddings’s care theory. I include caring themes for developing parity, using dialogue and reflection, and implementing modeling, practice, and confirmation. I also provide music educators and researchers with context for understanding the purposes, benefits, and challenges of collaborative teaching in music to guide implementation and inquiry.
The ICF2 gene Zbtb24 specifically regulates the differentiation of B1 cells via promoting heme synthesis
Authors: Gao He , Zhao Ying , Zhao Sai , Dai Xiao-Qiu , Qin Xiao-Yuan , Zheng Wei-Long , He Ting-Ting , Zhang Nan , Zhu Can , Wang Hong-Min , Pan Wen , Zhu Xue-Mei , Gao Xiao-Ming , Dai Jian-Feng , Gong Fang-Yuan , Wang Jun
Published: September 2024

Background

Loss-of-function mutations of ZBTB24 cause immunodeficiency, centromeric instability, and facial anomalies syndrome 2 (ICF2). ICF2 is a rare autosomal recessive disorder with immunological defects in serum antibodies and circulating memory B cells, resulting in recurrent and sometimes fatal respiratory and gastrointestinal infections. The genotype–phenotype correlation in patients with ICF2 indicates an essential role of ZBTB24 in the terminal differentiation of B cells.

Methods

We used the clustered regularly interspaced short palindromic repeats (CRISPER)/Cas9 technology to generate B cell specific Zbtb24-deficient mice and verified the deletion specificity and efficiency by quantitative polymerase chain reaction (Q-PCR) and western blotting analyses in fluorescence-activated cell sorting (FACS)-sorted cells. The development, phenotype of B cells and in vivo responses to T cell dependent or independent antigens post immunization were analyzed by flow cytometry and enzyme-linked immunosorbent assay (ELISA). Adoptive transfer experiment in combination with in vitro cultures of FACS-purified B cells and RNA-Seq analysis were utilized to specifically determine the impact of Zbtb24 on B cell biology as well as the underlying mechanisms.

Results

Zbtb24 is dispensable for B cell development and maintenance in naive mice. Surprisingly, B cell specific deletion of Zbtb24 does not evidently compromise germinal center reactions and the resulting primary and secondary antibody responses induced by T cell dependent antigens (TD-Ags), but significantly inhibits T cell independent antigen-elicited antibody productions in vivo. At the cellular level, Zbtb24-deficiency specifically impedes the plasma cell differentiation of B1 cells without impairing their survival, activation and proliferation in vitro. Mechanistically, Zbtb24-ablation attenuates heme biosynthesis partially through mTORC1 in B1 cells, and addition of exogenous hemin abrogates the differentiation defects of Zbtb24-null B1 cells.

Conclusions

Zbtb24 seems to regulate antibody responses against TD-Ags B cell extrinsically, but it specifically promotes the plasma cell differentiation of B1 cells via heme synthesis in mice. Our study also suggests that defected B1 functions contribute to recurrent infections in patients with ICF2.
Investigating key explanatory factors for safer long-distance bus services
Authors: Rahnama Shaghayegh , Cortez Adriana , Monzon Andres
Published: September 2024

Buses are among the most accessible and frequently used means of transport. Due to its importance, road safety analysis is frequently conducted to reduce accidents. This paper studied the relationship between weather conditions and the causes of accidents to improve road safety, focusing on long-distance services between Madrid and Bilbao (Spain). We employed Latent Class Clustering (LCC) and Hierarchical Ordered Logit models to identify these factors’ relationships. Additionally, Kaplan-Meier survival analysis was adopted to provide temporal insights into accident occurrences.

The main results show a downward trend in accidents since 2019, with manoeuvres being the most frequent cause. LCC reveals that “manoeuvres and car invading lanes in the opposite direction” in “clear and cloudy weather” has the highest probability of occurrence (63%). The hierarchical-ordered logit model indicates that rainy weather significantly affects all accident causes. Kaplan-Meier survival analysis reveals a vertical initial decline in survival probability within the first ten days, emphasizing a high initial accident risk.

The integrated approach used in this work provides a thorough understanding of accident hazards, which is its main contribution. By integrating LCC, Hierarchical Ordered Logit models and Kaplan-Meier survival analysis; we could offer a comprehensive and nuanced interpretation of the connection between weather and bus accidents. The findings highlight the need for rapid and sustained safety interventions, enhancing robustness and providing actionable insights for improving bus safety.
Analysis of miRNAs in milk of four livestock species
Authors: Cendron Filippo , Rosani Umberto , Franzoi Marco , Boselli Carlo , Maggi Flavio , De Marchi Massimo , Penasa Mauro
Published: September 2024

Background

Milk is essential for mammalian nutrition because it provides vital nutrients for growth and development. Milk composition, which is influenced by genetic and environmental factors, supports lactation, a complex process crucial for milk production and quality. Recent research has focused on noncoding RNAs, particularly microRNAs (miRNAs), which are present in body fluids and regulate gene expression post-transcriptionally. This study comprehensively characterizes miRNAs in milk of four livestock species, namely Bubalus bubalis, Capra hircus, Equus asinus, and Ovis aries and identifies potential target genes.

Results

High-throughput sequencing of milk RNA resulted in distinct read counts across species: B. bubalis (8,790,441 reads), C. hircus (12,976,275 reads), E. asinus (9,385,067 reads), and O. aries (7,295,297 reads). E. asinus had the highest RNA mapping rate (94.6%) and O. aries the lowest (84.8%). A substantially greater proportion of miRNAs over other small RNAs was observed for the donkey milk sample (7.74%) compared to buffalo (0.87%), goat (1.57%), and sheep (1.12%). Shared miRNAs, which included miR-200a, miR-200b, miR-200c, and miR-23a among others, showed varying expression levels across species, confirmed by qPCR analysis. Functional annotation of predicted miRNA target genes highlighted diverse roles, with an enrichment in functions linked to metabolism and immunity. Pathway analysis identified immune response pathways as significant, with several miRNAs targeting specific genes across species, suggesting their regulatory function in milk.

Conclusions

Both conserved and species-specific miRNAs were detected in milk of the investigated species. The identified target genes of these miRNAs have important roles in neonatal development, adaptation, growth, and immune response. Furthermore, they influence milk and meat production traits in livestock.
Unveiling the role of epigenetics in leaf senescence: a comparative study to identify different epigenetic regulations of senescence types in barley leaves
Authors: Rudy Elżbieta , Tanwar Umesh Kumar , Szlachtowska Zofia , Grabsztunowicz Magda , Arasimowicz-Jelonek Magdalena , Sobieszczuk-Nowicka Ewa
Published: September 2024

Background

Developmental leaf senescence (DLS) is an irreversible process followed by cell death. Dark-induced leaf senescence (DILS) is a reversible process that allows adaptations to changing environmental conditions. As a result of exposure to adverse environmental changes, plants have developed mechanisms that enable them to survive. One of these is the redirection of metabolism into the senescence pathway. The plant seeks to optimise resource allocation. Our research aims to demonstrate how epigenetic machinery regulates leaf senescence, including its irreversibility.

Results

In silico analyses allowed the complex identification and characterisation of 117 genes involved in epigenetic processes in barley. These genes include those responsible for DNA methylation, post-translational histone modifications, and ATP-dependent chromatin remodelling complexes. We then performed RNAseq analysis after DILS and DLS to evaluate their expression in senescence-dependent leaf metabolism. Principal component analysis revealed that evaluated gene expression in developmental senescence was similar to controls, while induced senescence displayed a distinct profile. Western blot experiments revealed that senescence engages senescence-specific histone modification. During DILS and DLS, the methylation of histone proteins H3K4me3 and H3K9me2 increased. H3K9ac acetylation levels significantly decreased during DILS and remained unchanged during DLS.

Conclusions

The study identified different epigenetic regulations of senescence types in barley leaves. These findings are valuable for exploring epigenetic regulation of senescence-related molecular mechanisms, particularly in response to premature, induced leaf senescence. Based on the results, we suggest the presence of an epigenetically regulated molecular switch between cell survival and cell death in DILS, highlighting an epigenetically driven cell survival metabolic response.
Combined application of biochar and peatmoss for mitigation of drought stress in tobacco
Authors: Zaman Qamar uz , Rehman Muzammal , Feng Youhong , Liu Zhiyuan , Murtaza Ghulam , Sultan Khawar , Ashraf Kamran , Elshikh Mohamed S. , Al Farraj Dunia A. , Rizwan Muhammad , Iqbal Rashid , Deng Gang
Published: September 2024

Drought poses a significant ecological threat that limits the production of crops worldwide. The objective of this study to examine the impact of soil applied biochar (BC) and peatmoss (PM) on the morpho-biochemical and quality traits of tobacco plants under drought conditions. In the present experiment work, a pot trial was conducted with two levels of drought severity (~ well-watered 75 ± 5% field capacity) and severe drought stress (~ 35 ± 5% field capacity), two levels of peatmoss (PM) @ 5% [PM+ (with peatmoss) and PM- (without peatmoss)] and three levels of rice straw biochar (BC0 = no biochar; BC1 = 150 mg kg− 1; and BC2 = 300 mg kg− 1 of soil) in tobacco plants. The results indicate that drought conditions significantly impacted the performance of tobacco plants. However, the combined approach of BC and PM significantly improved the growth, biomass, and total chlorophyll content (27.94%) and carotenoids (32.00%) of tobacco. This study further revealed that the drought conditions decreased the production of lipid peroxidation and proline accumulation. But the synergistic approach of BC and PM application increased soluble sugars (17.63 and 12.20%), soluble protein (31.16 and 15.88%), decreased the proline accumulation (13.92 and 9.03%), and MDA content (16.40 and 8.62%) under control and drought stressed conditions, respectively. Furthermore, the combined approach of BC and PM also improved the leaf potassium content (19.02%) by limiting the chloride ions (33.33%) under drought stressed conditions. Altogether, the balanced application of PM and BC has significant potential as an effective approach and sustainable method to increase the tolerance of tobacco plants subjected to drought conditions. This research uniquely highlights the combined potential of PM and BC as an eco-friendly strategy to enhance plant resilience under drought conditions, offering new insights into sustainable agricultural practices.
How did COVID-19 lockdown impact the health of older adults in nursing homes? A scoping review
Authors: San Martín-Erice Isabel , Escalada-Hernández Paula , García-Vivar Cristina , Furtado-Eraso Sara , San Martín-Rodríguez Leticia , Soto-Ruiz Nelia
Published: September 2024

Background

The impact of the COVID-19 pandemic on older adults in nursing homes is significant, with high death rates, disrupted care, isolation measures, and inadequate treatment. Social isolation has increased risks of cognitive disorders, anxiety, and depression. While many studies have examined the pandemic’s effects on nursing home staff and residents’ families, less is known about the health consequences for the residents themselves. This review aims to synthesize literature on the COVID-19 lockdown’s impact on the functional, cognitive, and psycho-emotional states of older adults in nursing homes.

Methods

A scoping review was conducted following the Joanna Briggs Institute guidelines and the PRISMA extension for Scoping Reviews (PRISMA-ScR). Four databases were searched: CINAHL, PubMed, Web of Science, and PsycINFO. The eligibility criteria included studies on older adults in nursing homes during the COVID-19 pandemic, with data that could be disaggregated for this population and results on the lockdown’s impact on physical, cognitive, and psycho-emotional levels.

Results

Seventeen articles met the criteria for data extraction The synthesis was categorized into four main areas: functional, cognitive and psycho-emotional status, and isolation measures. Key findings included decreased functional abilities, lower cognitive test scores during the pandemic’s first waves, development of psychological symptoms, and increased negative feelings among residents.

Conclusions

Highlighting the consequences of confinement for nursing home residents is essential for updating evidence, developing effective strategies, and establishing protocols to mitigate the impact and prevent health issues in future pandemics.
Parents’ perceptions of the safe environment for every kid (SEEK) model in the Swedish child health services
Authors: Golsäter Marie , Randell Eva , Engström Maria , Lucas Steven
Published: September 2024

Background

The Safe Environment for Every Kid (SEEK) model was developed to address psychosocial risk factors (financial worries, depressive symptoms, major parental stress, alcohol misuse and intimate partner violence) in the pediatric primary care setting but has not been evaluated from the parents’ perspective. To further investigate the usefulness of SEEK, it is important to explore how parents perceive the model.

Objective

The aim of the present study was to explore parents’ perceptions of the SEEK model as a part of regular health visits in the Child Health Services in Sweden.

Participants and setting

Eighteen parents (13 women and five men) in two Swedish counties participated in the study.

Methods

Semi-structured telephone interviews were conducted, and the resulting data were analyzed using reflective thematic analysis.

Results

Three themes were identified: Acceptance and understanding of the SEEK model in the child health services, The questionnaire as a bridge to a dialogue, and Feeling trust in the system and the child health nurse’s professional competence. Further, an overarching theme was created that encompassed a core meaning of all three themes; SEEK provides a process-oriented framework to receive support in parenting with a focus on child health.

Conclusions

The study showed that parents express both acceptance and understanding of the SEEK model and they perceive that the model provides an avenue for repeated dialogues about the family’s situation during the child’s upbringing and an opportunity to access support if needed.