bluuebunny/crossref_metadata_2025 huggingface dataset:
Stable Zinc-Based Metal-Organic Framework Photocatalyst for Effective Visible-Light-Driven Hydrogen Production
Authors: Dang Li-Long , Zhang Ting-Ting , Li Ting-Ting , Chen Tian , Zhao Ying , Zhao Chen-Chen , Ma Lu-Fang
Published: March 2022

Herein, a new Zn-MOF material, [Zn(L1)(L2)], 1, was built successfully through a one-pot solvothermal method. The 3D MOF structure was determined by Single X-ray diffraction analysis, IR, and elemental analysis. A series of PXRD tests of 1 after being immersed in different solvents and pH solutions demonstrated the good stability of 1. Interestingly, this material displayed high catalytic activity for the visible-light-driven hydrogen generation under the illumination of white LED in pure water or a mixture of DMF and H2O without additional photosensitizers and cocatalysts. Besides, the studies also showed that the catalytic activity changed constantly as well as the solvent ratio adjustment of DMF and H2O from 4:6 to 2:8. Additionally, the catalytic activity reached the best value (743 μmol g−1 h−1) when the solvent ratio was 4:6. The heterogeneous nature and recyclability of the MOF catalyst, as well as several factors that affect the catalytic activity, were investigated and described in detail. Moreover, the photocatalytic mechanism for the hydrogen generation of 1 was also proposed based on the fluorescence spectra and UV-vis absorption.
Special Issue “Bioactive Compounds from Natural Sources (2020, 2021)”
Authors: Sytar Oksana , Smetanska Iryna
Published: March 2022

In recent decades, there has been a huge level of interest in bioactive compounds from natural sources [...]
Unraveling the Structural, Dielectric, Magnetic, and Optical Characteristics of Nanostructured La2NiMnO6 Double Perovskites
Authors: Yi Kang , Tang Qingkai , Wu Zhiwei , Zhu Xinhua
Published: March 2022

Double perovskite La2NiMnO6 (LNMO) nanoparticles and nanorods were synthesized via a hydrothermal process, where only aqueous inorganic solvents are used to regulate the microscopic morphology of the products without using any organic template. They crystallized in a monoclinic (P21/n) double perovskite crystal structure. The LNMO nanoparticles exhibited spherical morphology with an average particle size of 260 ± 60 nm, and the LNMO nanorods had diameters of 430 ± 120 nm and length about 2.05 ± 0.65 μm. Dual chemical oxidation states of the Ni and Mn ions were confirmed in the LNMO samples by X-ray photoelectron spectroscopy. Strong frequency dispersion dielectric behavior observed in the LNMO ceramics, is attributed to the space charge polarization and the oxygen vacancy induced dielectric relaxation. A ferroelectric—paraelectric phase transition appearing near 262 K (or 260 K) in the LNMO ceramics prepared from nanoparticles (or nanorods) was identified to be a second-order phase transition. The LNMO samples are ferromagnetic at 5 K but paramagnetic at 300 K. The LNMO nanoparticles had larger saturation magnetization (MS = 6.20 μB/f.u. @ 5 K) than the LNMO nanorods (MS = 5.68 μB/f.u.) due to a lower structural disorder in the LNMO nanorods. The semiconducting nature of the nanostructured LNMO with an optical band gap of 0.99 eV was revealed by the UV–visible absorption spectra. The present results enable the nanostructured LNMO to be a promising candidate for practical spintronic devices.
An Externally-Applied, Natural-Mineral-Based Novel Nanomaterial IFMC Improves Cardiopulmonary Function under Aerobic Exercise
Authors: Akiyama Tomohiro , Hatakeyama Shinnosuke , Kawamoto Kazuhisa , Nihei Hideko , Hirata Takamichi , Nomura Tomohiro
Published: March 2022

Nanotechnology has widespread applications in sports; however, there are very few studies reporting the use of nanotechnology to enhance physical performance. We hypothesize that a natural-mineral-based novel nanomaterial, which was developed from Japanese hot springs, might overcome the limitations. We examined if it could enhance physical performance. We conducted a treadmill exercise test on 18 students of athletic clubs at Fukushima University, Japan, and measured heart rate, oxygen consumption, maximal oxygen consumption, CO2 production, and respiratory quotient 106 times in total. The results showed that the elevation of heart rate was significantly suppressed in the natural-mineral-based nanomaterial group, while no differences were observed in oxygen consumption, maximal oxygen consumption, CO2 production, and respiratory quotient between groups. To our knowledge, this result is the first evidence where an improvement of cardiovascular and pulmonary functions was induced by bringing a natural-mineral-based nanomaterial into contact with or close to a living body without pharmacological intervention or physical intervention. This could open new avenue of biomedical industries even in an eco-friendly direction. The precise mechanisms remain a matter for further investigation; however, we may assume that endothelial NO synthase, hemoglobin and endothelium-derived hyperpolarizing factor are deeply involved in the improvement of cardiovascular and pulmonary functions.
Ex Vivo Infection of Human Placental Explants by Trypanosoma cruzi Reveals a microRNA Profile Similar to That Seen in Trophoblast Differentiation
Authors: Medina Lisvaneth , Guerrero-Muñoz Jesús Alejandro , Liempi Ana Isabel , Castillo Christian , Ortega Yessica , Sepúlveda Alfredo , Salomó Fernando , Maya Juan Diego , Kemmerling Ulrike
Published: March 2022

Congenital Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is responsible for 22.5% of new cases each year. However, placental transmission occurs in only 5% of infected mothers and it has been proposed that the epithelial turnover of the trophoblast can be considered a local placental defense against the parasite. Thus, Trypanosoma cruzi induces cellular proliferation, differentiation, and apoptotic cell death in the trophoblast, which are regulated, among other mechanisms, by small non-coding RNAs such as microRNAs. On the other hand, ex vivo infection of human placental explants induces a specific microRNA profile that includes microRNAs related to trophoblast differentiation such as miR-512-3p miR-515-5p, codified at the chromosome 19 microRNA cluster. Here we determined the expression validated target genes of miR-512-3p and miR-515-5p, specifically human glial cells missing 1 transcription factor and cellular FLICE-like inhibitory protein, as well as the expression of the main trophoblast differentiation marker human chorionic gonadotrophin during ex vivo infection of human placental explants, and examined how the inhibition or overexpression of both microRNAs affects parasite infection. We conclude that Trypanosoma cruzi-induced trophoblast epithelial turnover, particularly trophoblast differentiation, is at least partially mediated by placenta-specific miR-512-3p and miR-515-5p and that both miRNAs mediate placental susceptibility to ex vivo infection of human placental explants. Knowledge about the role of parasite-modulated microRNAs in the placenta might enable their use as biomarkers, as prognostic and therapeutic tools for congenital Chagas disease in the future.
Development and Evaluation of Nanoparticles-in-Film Technology to Achieve Extended In Vivo Exposure of MK-2048 for HIV Prevention
Authors: Tong Xin , Patel Sravan Kumar , Li Jing , Patton Dorothy , Xu Elaine , Anderson Peter L. , Parikh Urvi , Sweeney Yvonne , Strizki Julie , Hillier Sharon L. , Rohan Lisa C.
Published: March 2022

MK-2048 is a second-generation integrase inhibitor active against HIV, which has been applied vaginally using ring formulations. In this work, a nanoparticle-in-film technology was developed as a discrete pre-exposure prophylactic product option against HIV for an extended duration of use. A film platform loaded with poly (lactic-co-glycolic acid) nanoparticles (PNP) encapsulating MK-2048 was engineered. MK-2048 PNPs were loaded into films that were manufactured via the solvent casting method. Physicochemical and mechanical properties, in vitro efficacy, Lactobacillus compatibility, in vitro and ex vivo permeability, and in vivo pharmacokinetics in macaques were evaluated. PNPs with a mean diameter of 382.2 nm and −15.2 mV zeta potential were obtained with 95.2% drug encapsulation efficiency. PNP films showed comparable in vitro efficacy to free MK-2048 (IC50 0.46 vs. 0.54 nM) and were found to have no impact on Lactobacillus. MK-2048 encapsulated in PNPs showed an increase in permeability (>4-fold) compared to the free MK-2048 in MDCKII cell lines. Furthermore, PNPs had higher ectocervical tissue permeability (1.7-fold) compared to free MK-2048. PNP films showed sustained drug levels for at least 3 weeks in the macaque vaginal fluid. This work demonstrates the synergy of integrating nanomedicine and polymeric film technology to achieve sustained vaginal drug delivery.
Late Quaternary Proboscidean Sites in Africa and Eurasia with Possible or Probable Evidence for Hominin Involvement
Authors: Haynes Gary
Published: March 2022

This paper presents a list of >100 publicly known late Quaternary proboscidean sites that have certain or possible traces of hominin utilization in Africa, Europe, and Asia, along with a sample of references, chronometric or estimated ages, and brief descriptions of the associated materials and bone modifications. Summary discussions of important sites are also presented. Lower Palaeolithic/Early Stone Age hominins created far fewer proboscidean site assemblages than hominins in later Palaeolithic phases, in spite of the time span being many times longer. Middle Palaeolithic/Middle Stone Age hominins created assemblages at eight times the earlier hominin rate. Upper Palaeolithic/Later Stone Age hominins created site assemblages at >90 times the rate of Lower Palaeolithic hominins. Palaeoloxodon spp. occur in nearly one third of the sites with an identified or probable proboscidean taxon and Mammuthus species are in nearly one half of the sites with identified or probable taxon. Other identified proboscidean genera, such as Elephas, Loxodonta, and Stegodon, occur in few sites. The sites show variability in the intensity of carcass utilization, the quantity of lithics bedded with bones, the extent of bone surface modifications, such as cut marks, the diversity of associated fauna, and mortality profiles.
Cloud Type and Life Stage Dependency of Liquid–Ice Mass Partitioning in Mixed-Phase Clouds
Authors: Yang Jing , Zhang Yue , Wang Zhien , Zhang Damao
Published: March 2022

This paper analyzes the temperature, cloud type, and life stage dependencies of phase partitioning in mixed-phase clouds spanning tropics, midlatitudes, and the Arctic, using data from ground-based remote sensing measurements in Alaska and aircraft measurements from three field campaigns. The results show: (1) The liquid fraction in Arctic stratiform clouds decreased from 1 to 0.6 between 0 °C and −30 °C and was lower in spring because of the higher dust occurrence in Barrow, Alaska; (2) In wintertime orographic clouds, the liquid fraction was greater than 0.8; (3) Phase partitioning in convective clouds varied significantly with life stages. In the developing stage, it decreased from 1 to 0.3 between −5 °C and −15 °C, indicating rapid ice generation, while at the mature and dissipating stages, the liquid fractions were lower; (4) The stratiform regions of mesoscale convective systems were dominated by ice, with liquid fractions lower than 0.2; and (5) The variability of phase partitioning varied for different cloud types. In stratiform clouds, liquid dominated at warm temperatures. As the temperature decreased, an ice-dominated region was more frequently observed, while the occurrence of the mixed-phase region remained low. For convective clouds, the variability of phase partitioning was controlled by continuous glaciation with decreasing temperature and life cycle.
Hazard Assessment of Rocky Slopes: An Integrated Photogrammetry–GIS Approach Including Fracture Density and Probability of Failure Data
Authors: Vanneschi Claudio , Rindinella Andrea , Salvini Riccardo
Published: March 2022

Natural rock slopes require accurate engineering–geological characterization to determine their stability conditions. Given that a natural rock mass is often characterized by a non-uniform fracture distribution, the correct, detailed, and accurate characterization of the discontinuity pattern of the rock mass is essential. This is crucial, for example, for identifying the possibility and the probability of kinematic releases. In addition, complete stability analyses of possible rockfall events should be performed and used to create hazard maps capable of identifying the most dangerous parts of a rock mass. This paper shows a working approach that combines traditional geological surveys and remote sensing techniques for engineering–geological investigations in a natural rock slope in Northern Italy. Discontinuities were identified and mapped in a deterministic way by using semi-automatic procedures that were based on detailed 3D Unmanned Aerial Vehicle photogrammetric-based point cloud data and provided georeferenced representations of thousands of fractures. In this way, detailed documentation of the geo-mechanical and geo-structural characteristics of discontinuities were obtained and subsequently used to create fracture density maps. Then, traditional kinematic analyses and probabilistic stability analyses were performed using limit equilibrium methods. The results were then managed in a GIS environment to create a final hazard map that classifies different portions of the rock slope based on three factors: kinematic predisposition to rockfall (planar sliding, wedge sliding, toppling), fracture density, and probability of failure. The integration of the three hazard factors allowed the identification of the most hazardous areas through a deterministic and accurate procedure, with a high level of reliability. The adopted approach can therefore be very useful to determine the areas in which to prioritize remediation measures with the aim of reducing the level of risk.
Examination of 93 cases of perianal warts and suggestion of a new classification
Authors: Unotoro Jo , Matsuo Keigo , Arai Takehiro , Okada Shigeru , Kawanishi Teruki , Ikegami Ryoichi , Mori Shuzo , Matsuno Hiroshi
Published: March 2022

Purpose: The anatomical distribution of perianal warts is associated with patient characteristics such as sexual orientation. The purpose of this study is to confirm this experiential knowledge using a quantitative classification system and analysis and to obtain findings useful for future treatment.Methods: From January 2014 to December 2020, 93 patients with perianal warts presented to our hospital. Patients were analyzed for age, sex, lesion site, and recurrence type, among other factors. The lesion site was divided into skin (S) and anal epithelium (anoderm, A), and the number and degree of each were classified into grades 0 to 3. The higher grade between S and A determines its dominant type, such as type S (e.g., S3A1) and type A (e.g., S0A2).Results: The average age of the patients was 39.6 years, and the percentage of patients who were not married was 54.8%. In all, 95.8% of patients were positive for low-risk human papillomavirus (HPV). Type S accounted for 80.6%, whereas type A accounted for 9.7%. Type A cases were all male and were all presumed to be men who have sex with men (MSM). This indicates that the determination of type A may be highly specific for MSM. The type at the time of recurrence was the same type at the time of the first surgery in almost all cases.Conclusion: In cases of perianal warts, it is useful to analyze the lesion by considering the range and grade separately for daily clinical practice on proctologist.
Dizer sem poder dizer
Authors: Da Silva Felipe Alves
Published: March 2022

A partir de textos de Primo Levi e da argumentação apresentada por Giorgio Agamben de que o testemunho seria um paradoxo, busca-se investigar os limites da linguagem autoral, discutindo a respeito de como se daria o testemunho daqueles que no campo de concentração pereceram, ou melhor, para usar um conceito de Levi, como o não-homem (non-uomini) falaria através do homem. O estudo pretende demonstrar a importância da literatura de testemunho, pois seria por intermédio dela que o sobrevivente exerce o imperativo de narrar sua experiência em nome de outro. Objetiva-se tratar sobre as limitações da linguagem, de modo que auxilie a fundamentar ainda mais a autenticidade dos sobreviventes em poder falar em nome de um não-poder dizer, um falar no lugar do outro.
patologias da memória em Canguilhem, Sartre e Hersch
Authors: Sass Simeão
Published: March 2022

O estudo aborda o tema da memória a partir de suas correlações com teorias contemporâneas desenvolvidas por dois representantes emblemáticos da filosofia francesa: Canguilhem e Sartre. Tomando como objeto de contraponto duas obras desses pensadores publicadas em 1943, O normal e o patológico e O Ser e o Nada, empreenderemos análises acerca de temas essenciais ao saber contemporâneo. Os principais tópicos são: a crítica ao determinismo, a relação entre quantidade e qualidade, as relações entre o normal e o patológico, o modo de viver e, por fim, o valor. A análise desses tópicos demonstrará que o conceito de memória está vinculado ao modo como cada ser humano constitui sua temporalidade e seu modo de viver. Na conclusão, abordaremos a obra de Edwin L. Hersch e sua teoria do “feixe de luz”. Nessa teoria encontraremos reflexões relevantes para a valorização do conceito de imaginário na filosofia, na psicologia e na psicopatologia.
Caixa de Pandora
Authors: Kossovitch Leon , De Moraes Sérgio
Published: March 2022

Leon Kossovich analisa lineogravuras de Sérgio de Moraes.
O que é o contemporâneo (no teatro brasileiro)? Reflexões orientadas por e para o professor Celso Favaretto
Authors: Kon Artur Sartori
Published: March 2022

Com este ensaio, gostaria de celebrar o trabalho do professor Celso Favaretto explicitando sua contribuição fundamental para nossa formação. Tanto no convívio propiciado pela orientação acadêmica quanto em sua própria produção teórica, o pensador homenageado tem oferecido brilhantes ferramentas e formulações sobre a arte contemporânea, sobretudo brasileira, as quais têm enorme potencial no sentido de lançar luz sobre meu objeto de estudo, o recente teatro paulistano, ao qual ele mesmo não se dedicou com maior profundidade.
Celso, professor e amigo
Authors: Müller Regina Polo
Published: March 2022

Depoimento em homenagem a Celso Favaretto.
Quelques propositions pour Genève et ses parcs
Authors: Lévy Bertrand
Published: March 2022

L'article relève des contradictions entre le dire et le faire en matière d'écologie végétale et urbaine. Cet article, basé sur des observations de terrain et des échanges avec des usagers et des responsables de l'aménagement, se focalise sur les parcs urbains, le parc Bertrand à Genève en particulier. Il émet quelques propositions concrètes d''écologie de proximité.
Hélios: Solar Tracker para Sistemas Fotovoltaicos Off-Grid baseado na plataforma Arduino / Hélios: Solar Tracker for Off-Grid Photovoltaic Systems based on the Arduino platform
Authors: Franco George Alexandre da Silva , Ferreira Victor Andrade Lima , Chaves Alexsandra Cristina , Costa Antonio Alexandre Moura , Neto José Torres Coura , Cruz Igor Gomes de Meneses , Gonçalves Délis da Conceição Nascimento , De Araújo Kaylane Kelly Santos
Published: March 2022

Dentre as formas de energias renováveis disponíveis, a solar se apresenta para o Brasil como uma das escolhas mais adequadas. Fato este que se dá principalmente pela alta incidência de radiação solar e pelas poucas variações climáticas sazonais, o que resulta em importantes vantagens técnicas e econômicas dos sistemas solares instalados nesta região, principalmente: os sistemas não geram poluição sonora nem resíduos; possibilidade de uso de sistemas off-grid em locais remotos e de difícil acesso, gerando economia em linhas de transmissão; longa vida útil dos sistemas; possibilidade de uso durante todo o ano sem grandes variações no rendimento dos sistemas e a manutenção necessária deste tipo de sistema é muito menor que em outros sistemas de conversão de energia em energia elétrica. A região Nordeste destaca-se, entre as regiões do Brasil, em número médio de horas de insolação. O índice de insolação diária, na média anual, da região alcança o valor de 8 horas diárias. Esses fatores, tornam o aproveitamento da energia solar viável em praticamente qualquer época do ano e abrem uma oportunidade para que o estudo de Física se aproxime da realidade dos alunos, ao se apropriar de situações cotidianas. A presente pesquisa pretende projetar e construir um seguidor solar (solar tracker), ou seja, um dispositivo utilizado para manter os painéis fotovoltaicos posicionados de modo a obterem a máxima conversão de energia solar em energia elétrica. A prototipagem é baseada na plataforma Arduino. A utilização deste recurso resulta em um aumento de até 40% no rendimento dos painéis solares. O projeto está sendo desenvolvido com alunos do curso Técnico em Informática, vislumbrando a promoção do desenvolvimento da Ciência e Tecnologia.
Preoperative Prediction of Lymph Node Metastasis in Colorectal Cancer with Deep Learning
Authors: Liu Hailing , Zhao Yu , Yang Fan , Lou Xiaoying , Wu Feng , Li Hang , Xing Xiaohan , Peng Tingying , Menze Bjoern , Huang Junzhou , Zhang Shujun , Han Anjia , Yao Jianhua , Fan Xinjuan
Published: March 2022

Objective
. To develop an artificial intelligence method predicting lymph node metastasis (LNM) for patients with colorectal cancer (CRC).
Impact Statement
. A novel interpretable multimodal AI-based method to predict LNM for CRC patients by integrating information of pathological images and serum tumor-specific biomarkers.
Introduction
. Preoperative diagnosis of LNM is essential in treatment planning for CRC patients. Existing radiology imaging and genomic tests approaches are either unreliable or too costly.
Methods
. A total of 1338 patients were recruited, where 1128 patients from one centre were included as the discovery cohort and 210 patients from other two centres were involved as the external validation cohort. We developed a Multimodal Multiple Instance Learning (MMIL) model to learn latent features from pathological images and then jointly integrated the clinical biomarker features for predicting LNM status. The heatmaps of the obtained MMIL model were generated for model interpretation.
Results
. The MMIL model outperformed preoperative radiology-imaging diagnosis and yielded high area under the curve (AUCs) of 0.926, 0.878, 0.809, and 0.857 for patients with stage T1, T2, T3, and T4 CRC, on the discovery cohort. On the external cohort, it obtained AUCs of 0.855, 0.832, 0.691, and 0.792, respectively (T1-T4), which indicates its prediction accuracy and potential adaptability among multiple centres.
Conclusion
. The MMIL model showed the potential in the early diagnosis of LNM by referring to pathological images and tumor-specific biomarkers, which is easily accessed in different institutes. We revealed the histomorphologic features determining the LNM prediction indicating the model ability to learn informative latent features.
Migrant-Health Inequity as a Consequence of Poor Siracusa Principles Implementation in the COVID-19 Era
Authors: Mukumbang Ferdinand C.
Published: March 2022

The Siracusa Principles dictate that restrictions on the rights of individuals or a group of individuals in the name of public health safety should be strictly necessary and be least intrusive to reach their objective. While social distancing measures have proven to abide by the Siracusa Principles to a more significant extent, they have failed to meet the distributive justice laws, which require limiting unfair or inequitably personal and economic burdens on the nation’s inhabitants. While employing social distancing measures, the principle of reciprocity also obliges governments to provide the people living within their borders with life necessities. Although asylum-seekers, refugees, and undocumented migrants already disproportionately bear the brunt of the coronavirus disease 2019 (COVID-19) pandemic, poor application of the Siracusa Principles in social distancing measures seems to intensify their vulnerabilities. We argue that while implementing public health measures that could potentially impact the lives and livelihoods of the people living within the nation, considerations should also be paid to minority groups such as asylum-seekers, refugees, and undocumented migrants. We propose that the application of the social distancing measures should be ‘migration aware, adapting interventions, policies, and setting systems that embed migration as a central concern in their design.
Inequalities in Accessing Healthcare in the United States of America: A Major Contributor to the Increasing COVID-19 Morbidity and Mortality
Authors: Ilesanmi Olayinka Stephen , Afolabi Aanuoluwapo Adeyimika , Awoniyi Oluwafunbi
Published: March 2022

Introduction: Many COVID-19 cases and deaths have been reported from the United States (US). This study aimed to assess the health system inequalities as a determinant of COVID-19 case morbidity and mortality in the US. Methods: This study collected data on US COVID-19 cases and deaths as of the 27th of January 2021 from the Worldometer and COVID-19 Community Vulnerability Index. The strength of association between the social vulnerability index (SVI), total COVID-19 deaths and tests, and regional population in the US were determined using Pearson’s correlation. P values<0.05 were statistically significant. Results: New York has the highest SVI (0.94) in the North-Eastern region and the highest percentage of non-Whites. California has the highest SVI (0.90) in the Western region and the highest proportion of Asians. In the mid-Western region of the US, Illinois has the highest SVI (0.88) and the highest proportion of African Americans and Asians. North Carolina has the highest SVI of (1.00) in the Southern region and the highest proportion of African Americans. A strong positive correlation exists between the SVI and total COVID-19 tests (P=0.001) in the North-eastern and Southern regions (P=0.025). In addition, a positive correlation (P<0.039) exists between SVI and the total population in the Western and mid-Western regions (P<0.003). Conclusion: Multi-sectoral collaboration should be encouraged to promote equity in accessing COVID-19 healthcare in the US, especially in States with high COVID-19 SVI.
Ovarian Hyperstimulation Syndrome Risk Factors in Assisted Reproductive Technologies (Review)
Authors: Жуковская С.В.мл , Жуковская С.В.
Published: March 2022

Синдром гиперстимуляции яичников (СГЯ) представляет собой преимущественно ятрогенное осложнение, возникающее в результате применения гормональных препаратов с целью индукции фолликулогенеза. Совокупная частота всех форм СГЯ достигает 30–33% от общего числа программ экстракорпорального оплодотворения, в то время как тяжелая и критическая формы синдрома потенциально летальны, что обусловливает необходимость своевременного выявления факторов риска развития этого осложнения. В статье представлены результаты анализа современной научной литературы, освещающие прогностическую ценность основных маркеров риска развития СГЯ.

Ovarian hyperstimulation syndrome (OHSS) is a mainly iatrogenic complication of controlled ovarian stimulation in assisted reproductive technologies (ART). Commonly, prevalence of OHSS constitutes up to 30–33% of all in-vitro fertilization programs, while at the same time severe and critical forms of this syndrome are potentially lethal, which explains the necessity of studies aimed at establishing significant risk factors. This article presents the results of contemporary scientific literary review focused on evaluating prognostic value of OHSS clinical and laboratory prognostic markers.
The Uterus Couvelaire: the Possibility of Preserving the Reproductive Organ (Clinical Case)
Authors: Можейко Л.Ф. , Марковская Т.В. , Коршикова Р.Л. , Дядичкина О.В. , Федотова Э.В. , Стасевич С.М.
Published: March 2022

В настоящей работе представлен клинический случай преждевременной отслойки нормально расположенной плаценты, осложненной антенатальной гибелью плода и развитием матки Кувелера в сроке гестации 232 дня. Данная патология возникла у беременной женщины с отягощенным акушерским анамнезом из группы материнского риска по инфицированию, невынашиванию, развитию фетоплацентарной недостаточности, преэклампсии, тромбоэмболическим осложнениям. Оптимальная утеротоническая, гемотрансфузионная и гемостатическая терапия с использованием современных оперативных методик позволила сохранить репродуктивный орган и его функцию женщине, желающей еще иметь детей.

This paper presents a clinical case of premature detachment of the normally located placenta, complicated by antenatal fetal death and development of the Couvelaire uterus at the gestation period of 232 days. This pathology occurred in a pregnant woman with a burdened obstetric history from the group of maternal risk for infection, miscarriage, development of fetoplacental insufficiency, preeclampsia, and thromboembolic complications. Timely uterotonic, hemotransfusion and hemostatic therapy with the use of modern surgical techniques allowed to preserve the reproductive organ and its function for a woman who wants to have more children.
Non-routine psychopharmacology of depression
Authors: Скугаревский О.А.
Published: March 2022

В статье приводятся актуальные данные о согласованных экспертных подходах к терапии депрессии с учетом баланса безопасности и эффективности современных психофармакологических средств. В сравнительном аспекте представлен новый для отечественного рынка антидепрессант миртазапин. Обсуждена возможность его использования в нерутинных клинических ситуациях: при терапевтически резистентной депрессии, депрессии у пациентов с проблемным потреблением психоактивных веществ, у пожилых пациентов, при расстройствах сна, соматических расстройствах, сопровождаемых депрессией.

In this article we provide actual data on coherent expert opinions in the treatment of depression with the matter of balance between safety and efficacy of modern antidepressants. In the comparative manner modern antidepressive drug mirtazapine is presented. Its implementation in non-routine clinical cases is discussed: treatment-resistant depression, depression in the cases of psychoactive substances abuse, depression in the elderly people, insomnia treatment, depressive features in somatic disorders.
Syndrome of Depersonalization in Disorders of Schizophrenic Spectrum
Authors: Дьяконов А.Л.
Published: March 2022

Работа посвящена изучению особенностей клиники, диагностики и динамики деперсонализационных расстройств в структуре заболеваний шизофренического спектра. Обследовано 32 пациента с эпизодическим типом течения параноидной шизофрении и шизотипическим расстройством. Установлено, что при указанных заболеваниях деперсонализация представлена всеми тремя вариантами: аутопсихической, соматопсихической и аллопсихической. По мере клинического улучшения состояния явления деперсонализации могли исчезать или усложняться при последующих рецидивах заболевания. Во время приступов шизофрении деперсонализация в начале наблюдения не была созвучна с бредом, существовала автономно (бредовая деперсонализация изначально из исследования исключалась), но при катамнестическом наблюдении деперсонализация становилась дефектной или бредовой, срастаясь с бредом. По мере нарастания негативной симптоматики деперсонализация постепенно тускнела, стиралась.

The work is devoted to the study of clinical features, diagnostics and dynamics of depersonalization disorders in the structure of schizophrenic spectrum diseases. There were examined 32 patients with episodic type of paranoid schizophrenia and schizotypic disorder. It was found that in these diseases, depersonalization is represented by all three options: autopsychic, somatopsychic and allopsychic. With clinical improvement, the phenomena of depersonalization could disappear or become more complicated with subsequent relapses of the disease. During schizophrenia attacks, depersonalization in the early observation was not consonant with delusion, it existed autonomously (delusional depersonalization was initially excluded from research). However, in follow up supervision, depersonalization was found defective or delusional, fused with delusion. With the growth of the negative symptoms, depersonalization gradually faded, erased.
The Jordanian Version of the Grief Cognition Questionnaire: Factor Analysis, Validityand Reliability
Authors: Басим А. , Нур О.
Published: March 2022

Это исследование было направлено на то, чтобы систематизировать вопросник по познанию горя (GCQ) для иорданского контекста путем проверки его психометрических свойств. Выборка состояла из 645 участников в возрасте от 18 лет и старше, которые испытали потери в течение последних 6 месяцев после исследования. Были использованы исследовательский факторный анализ (EFA) и подтверждающий факторный анализ (CFA). Результаты EFA показали пять факторов с объяснением 62,245% дисперсии. Этими факторами были негативные представления о себе, мире и будущем и лелеющие и угрожающие интерпретации после потери. Был проведен CFA для проверки правильности пяти факторов. Результаты показали, что модифицированная модель согласуется с данными. Альфа-коэффициент Кронбаха для общего GCQ составлял 0,97, а для подшкал – от 0,89 до 0,94. На основании этих результатов можно было определить, что этот инструмент обладает достаточными психометрическими свойствами, чтобы его можно было использовать и применять в иорданском контексте вкачестве надежного и последовательного инструмента для оценки когнитивных мыслей после потери.

This study aimed to codify the Grief Cognition Questionnaire (GCQ) for the Jordanian context by testing its psychometric properties. The sample consisted of 645 participants aged 18 years or older who had experienced a loss within the past 6 months of the time of the study. An exploratory factor analysis (EFA) and a confirmatory factor analysis (CFA) were used. The results of the EFA showed five factors, with 62.245% of the variance explained. These factors were negative cognitions about the self, world, and future and cherishing and threatening interpretations after loss. A CFA was performed to test the validity of the five factors. The results showed that the modified model was consistent with the data. The Cronbach’s alpha coefficient for the total GCQ was .97 and was between .89 and .94 for the subscales. Based on these results, it was possible to determine that this tool had sufficient psychometric properties to be applied and adopted in the Jordanian context as a valid, reliable and consistent tool for evaluating postloss cognitive thoughts.
Mediation in Medicine in Belarus and Abroad
Authors: Каменков В.С. , Сурма Л.А.
Published: March 2022

Возможность интеграции медицинского сообщества в системы оценки качества медицинской помощи и досудебного урегулирования конфликтов, отсутствие эффективных механизмов защиты, как врачей, так и пациентов, противоречия в нормативно-правовой базе, неоднозначность трактовок действий врачей, неразвитость инструментов внесудебного урегулирования конфликтов, зачастую неправильное использование культурных или религиозных ценностей – это те проблемы, которые приводят к возникновению конфликтов, а порой даже и споров в сфере медицины. Ответ на вопрос, как профессионально и деликатно решать конфликтные ситуации без судебного или арбитражного разбирательства, но с помощью института медиации, авторы представили в данной статье. Также рассмотрены злободневные и важные для медицины в целом, для экономики многих медицинских учреждений и их пациентов, для здоровья многих пациентов вопросы использования медиативных процедур в медицине.

The possibility of integrating the medical community into the systems of assessment of the quality of medical care and pre-trial settlement of conflicts, the lack of effective protection mechanisms for both doctors and patients, the contradictions in the regulatory framework that lead to ambiguous interpretations of physicians’ actions, underdeveloped tools of pre-trial conflict resolution, lack of communication, misuse of cultural or religious values – these are the problems that lead to conflicts and sometimes even disputes in the field of medicine. The answer to the question of how to resolve conflict situations professionally and delicately without judicial or arbitral proceedings, but with the help of the mediation institution, is presented in this article. The authors also considered the use of mediation procedures in medicine, which is important and even urgent issue for medicine in general, for economies of many medical institutions and their patients.
Trichoscopy is a Universal Method of Diagnostics and Differential Diagnosis of Dermatoses with Localization on the Scalp
Authors: Крук Н.И. , Шиманская И.Г.
Published: March 2022

Введение. Терапия потери волос различной этиологии, а также дерматозов с локализацией на волосистой части головы зачастую осложняется отсутствием стандартизированной диагностики, а также эффективного метода оценки проводимой терапии.Цель исследования. Оценить возможность использования трихоскопии в качестве универсального метода диагностики и дифференциальной диагностики дерматозов с локализацией на волосистой части головы (ВЧГ).Материалы и методы. 334 пациента, находившихся на амбулаторном лечении в Городском клиническом кожно-венерологическом диспансере и Республиканском центре медицинской реабилитации и бальнеолечения с патологией ВЧГ.Результаты. В ходе исследования впервые были систематизированы трихоскопические понятия, определена клиническая значимость совокупности трихоскопических критериев для неинвазивной диагностики дерматозов, на достаточном количестве клинических наблюдений продемонстрирована их роль при дифференциальной диагностике дерматозов.

Introduction. Therapy for hair loss of various etiologies, as well as dermatoses with localization on the scalp, is often complicated by the lack of standardized diagnostics, as well as an effective method for evaluating the therapy.The purpose of the study is to evaluate the possibility of using trichoscopy as a universal method of diagnosis and differential diagnosis of dermatoses with localization on the scalp.Materials and methods. 334 patients who were on the treatment with pathology of the hair and scaip.Results. In the course of the study, trichoscopic concepts were systematized for the first time, the clinical significance of a set of trichoscopic criteria for the non-invasive diagnosis of dermatoses wasdetermined, their role in the differential diagnosis of dermatoses was demonstrated on a sufficient number of clinical observations.
The Spectrum of Basic Clinical and Laboratory Tests Recommended for Use by the International Federation of Clinical Chemistry (IFCC) for the Study of Patients with Coronavirus Infection COVID-19: Features of the State of Certain Key Metabolic Links in Unfavorable Course of the Disease*
Authors: Камышников В.С.
Published: March 2022

В статье приведены сведения об использовании надлежащих клинико-лабораторных тестов для исследования состояния жизненно важных органов и систем пациентов с коронавирусной инфекцией COVID-19. Представлена характеристика ключевых звеньев метаболизма, для оценки состояния которых при этом виде патологии используются приведенные в рекомендациях IFCC и другие лабораторные тесты. Дана трактовка изменениям лабораторных показателей при неблагоприятном прогнозе развития заболевания.Предложены направления дальнейших исследований, связанных с оценкой факторов формирования мембранной патологии, фибротических изменений в легочной ткани.* Информация о перечне лабораторных тестов для осуществления биохимического мониторинга пациентов с COVID-19 взята с сайта IFCC: www.ifcc.org/ifcc-news/2020-03-26-ifcc-information-guide-on-covid-19/* Information on the list of laboratory tests for biochemical monitoring of patients with COVID-19 is taken from the IFCC website: www.ifcc.org/ifcc-news/2020-03-26-ifcc-information-guide-on-covid-19/

The article provides information on the use of appropriate clinical and laboratory tests to study the state of vital organs and systems of patients with coronavirus infection COVID-19. The article presents the characteristics of the key metabolic links, to assess the state of which in this type of pathology, the IFCC recommendations and other laboratory tests are used. The interpretation is given to the changes of laboratory parameters in case of unfavorable prognosis of development of the disease.The directions of further research related to the assessment of the factors of formation of membrane pathology, fibrotic changes in the lung tissue are proposed.
Simulacra Laptop (Post-modern Study of Virtual World Communication Laptop Users Among FISIP UNS Students)
Authors: Adhitya Putri Dwi
Published: March 2022

This research is a qualitative descriptive research. The informants in this research are the student of FISIP UNS as laptop users. The data collection techniques were conducted through in-depth interviews, observation of a role and documentation, whereas the sampling of research was conducted with a “purposive sampling” technique. The data analysis is interactive analysis includes data reduction, data display, and conclusion. The results showed that the virtual world of communication which was accessed by student of FISIP UNS as a laptop users are false or not real, they communicate and made a friendship in unreal space. In the social networking Facebook access the communication in the virtual world is one of popular internet accesses in the student of FISIP UNS as laptop users. In view of social side, social networking Facebook is very useful to establish relations of friendship, either new friends or old friends. In the social networking the communication of virtual world, they can fall out their feelings or share stories with friends on these social networks. In the other hand the social networking also open an opportunity business; develop a talent of writing and many others. Besides, there are the weakness of the existence of the virtual world of communication, ie: affectivities time experienced by students of FISIP UNS as a laptop users, and the virtual world crime experienced by some informants that are student of FISIP UNS as a laptop users . To minimize the virtual world crime.
El castillo y el primer escudo de armas de Cintruénigo
Authors: Olcoz Serafín , Medrano Manuel
Published: March 2022

Este trabajo pretende analizar el emblema del Concejo de Cintruénigo, recogido en su sello más antiguo, tanto la leyenda como los elementos iconográficos que figuran en el mismo. De esta forma, también, contribuimos a conocer mejor la evolución de las fortificaciones de época medieval que allí se construyeron y de la población urbana en los siglos XVI y XVII.
Aproximación al linaje del eitán del primer rey de Aragón
Authors: Olcoz Yanguas Serafín
Published: March 2022

Se analiza un posible caso de barraganía en el siglo XI, en el reino de Aragón, y se pone en el contexto del linaje descendiente de un destacado personaje de dicha corte, como fue Jimeno Garcés, eitán del primer rey de Aragón. Un linaje en el que la homonimia de sus miembros había venido dificultando su identificación.
Judería y chapitel. La repoblación de la Navarrería en 1321
Authors: Arrizabalaga Lizarraga Rafael
Published: March 2022

En este artículo se pretende aportar luz a las preguntas de por qué, cuándo y cómo se llevó a efecto el trazado urbano de la renacida ciudad de la Navarrería. Se trata de un exhaustivo estudio que ha profundizado en todos los registros de pagos de rentas, cartas, privilegios y libros de fuegos relacionados con estos primeros vecinos que la repoblaron. El análisis de datos históricos se completa con el estudio de la planimetría de la ciudad actual, una realidad física que se ha conservado bastante bien, aun sufriendo alteraciones que hoy permanecen invisibles. El resultado es sorprendente, ya que relaciona el presente con los primeros repobladores que levantaron sus edificaciones.
Una carta de Bartolomé de Zuloaga al virrey Pedro de Foix sobre las «cosas de Navarra»
Authors: De Azcona Tarsicio
Published: March 2022

Se analiza y se publica la carta enviada por Bartolomé de Zuloaga, tesorero real de descargos y embajador de los Reyes Católicos, dirigida al cardenal-virrey de Navarra, Pedro de Foix y Albret. Esta fuente ofrece abundantes noticias históricas sobre los reyes Fernando e Isabel, así como sobre el plan político peninsular y europeo de estos, con especial referencia a Navarra. La edición de la carta se complementa con la de otra documentación relativa a Zuloaga.
Navigating narrow straits: Leadership development of municipal managers of non-policing law enforcement services
Authors: Young Dean
Published: March 2022

As municipal governments continue to use non-police law enforcement (NPLE) personnel in pursuit of public safety strategies, managers tasked with overseeing such staff are typically those without experience in the intricacies of law enforcement, public disorder, and the justice system. Non-police law enforcement calls for the use of very special skills, knowledge, and abilities not typically experienced in other areas of municipal operations. Managers, regardless of their profession, can effectively manage NPLE when afforded the opportunity to learn the law enforcement perspective, understand the stressors placed on enforcement staff, and be educated in the judicial requirements of municipal and provincial enforcement. Municipalities should refrain from placing staff under a manager strictly for ease and convenience. Further, the services provided should operate with proper oversight. Managers must be appropriately experienced in leading staff and operations involving complex and human-centred portfolios. This study outlines the issues faced by managers tasked with overseeing NPLE and provides a snapshot of the current professional structure of NPLE leadership in the province of Alberta, Canada.
Education, preparation, and moral obligation: An examination of hospital employee role in active shooter training response
Authors: Wood McKenzie , Darais Mallory
Published: March 2022

As active shooter and armed intruder events continue to increase, hospitals have recently begun using the Department of Homeland Security-endorsed “Run Hide Fight” procedures to train employees on how to respond to violent situations. This study uses survey data collected from 333 staff in various employee roles at a Midwest hospital. Employees responded to questions related to “Run Hide Fight” policy education, feelings of preparedness for an active shooter event, and perceptions of moral obligation related to remaining with patients during a potentially fatal encounter. Results indicate variations in education and preparedness response among administration, clinical staff, and non-clinical staff.