bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Advances on Iron(III) Selective Fluorescent Probes with Possible Applications in Bioimaging
Authors: Sahoo Suban K. , Crisponi Guido
Published: September 2019

Iron(III) is well-known to play a vital role in a variety of metabolic processes in almost all living systems, including the human body. However, the excess or deficiency of Fe3+ from the normal permissible limit can cause serious health problems. Therefore, novel analytical methods are developed for the simple, direct, and cost-effective monitoring of Fe3+ concentration in various environmental and biological samples. Because of the high selectivity and sensitivity, fast response time, and simplicity, the fluorescent-based molecular probes have been developed extensively in the past few decades to detect Fe3+. This review was narrated to summarize the Fe3+-selective fluorescent probes that show fluorescence enhancement (turn-on) and ratiometric response. The Fe3+ sensing ability, mechanisms along with the analytical novelties of recently reported 77 fluorescent probes are discussed.
Characterization and Quantification of Major Flavonol Glycosides in Ramps (Allium tricoccum)
Authors: Dabeek Wijdan M. , Kovinich Nik , Walsh Callee , Ventura Marra Melissa
Published: September 2019

The ramp (Allium tricoccum) is a traditional plant in the eastern Appalachian Mountains. Ramps have been used in traditional medicine for their health-promoting roles in lowering blood pressure and cholesterol. Information on the chemical composition of the potentially bioactive components in ramps is limited. Therefore, the aim of this work was to characterize and quantify major flavonols in ramps. Flavonoids were extracted in 50% methanol and 3% acetic acid. Characterization was conducted using UHPLC-PDA-MS and MS/MS, and quantification was performed using UHPLC-PDA detection. The major flavonol glycosides were kaempferol sophoroside glucuronide, quercetin sophoroside glucuronide, kaempferol rutinoside glucuronide, quercetin hexoside glucuronide, quercetin sophoroside, and kaempferol sophoroside. All conjugates were detected in leaves. Quercetin and kaempferol sophoroside glucuronide conjugates were detected in the stem, but no flavonol glycosides were detected in the bulb. The total amounts of the identified quercetin and kaempferol conjugates in whole ramps were 0.5972 ± 0.235 and 0.3792 ± 0.130 mg/g dry weight, respectively. Flavonol conjugates were concentrated in the leaves. To our knowledge, this work is the first to identify and quantify the major flavonol glycosides in ramps. Our findings suggest that specifically the leaves may harbor the potentially bioactive flavonols components of the plant.
Nanomaterials Based on Fe3O4 and Phthalocyanines Derived from Cashew Nut Shell Liquid
Authors: Ribeiro Viviane G. P. , Mota João P. F. , Costa Júnior Antônio E. , Lima Nayane M. A. , Fechine Pierre B. A. , Denardin Juliano C. , Carbone Luigi , Bloise Ermelinda , Mele Giuseppe , Mazzetto Selma E.
Published: September 2019

In this work we report the synthesis of new hybrid nanomaterials in the core/shell/shell morphology, consisting of a magnetite core (Fe3O4) and two consecutive layers of oleic acid (OA) and phthalocyanine molecules, the latter derived from cashew nut shell liquid (CNSL). The synthesis of Fe3O4 nanoparticle was performed via co-precipitation procedure, followed by the nanoparticle coating with OA by hydrothermal method. The phthalocyanines anchorage on the Fe3O4/OA core/shell nanomaterial was performed by facile and effective sonication method. The as obtained Fe3O4/OA/phthalocyanine hybrids were investigated by Fourier transform infrared spectroscopy, X-ray diffraction, UV-visible spectroscopy, transmission electron microscopy (TEM), thermogravimetric analysis and magnetic measurements. TEM showed round-shaped nanomaterials with sizes in the range of 12–15 nm. Nanomaterials presented saturation magnetization (Ms) in the 1–16 emu/g and superparamagnetic behavior. Furthermore, it was observed that the thermal stability of the samples was directly affected by the insertion of different transition metals in the ring cavity of the phthalocyanine molecule.
Synthesis of Pluri-Functional Amine Hardeners from Bio-Based Aromatic Aldehydes for Epoxy Amine Thermosets
Authors: Mora Anne-Sophie , Tayouo Russell , Boutevin Bernard , David Ghislain , Caillol Sylvain
Published: September 2019

Most of the current amine hardeners are petro-sourced and only a few studies have focused on the research of bio-based substitutes. Hence, in an eco-friendly context, our team proposed the design of bio-based amine monomers with aromatic structures. This work described the use of the reductive amination with imine intermediate in order to obtain bio-based pluri-functional amines exhibiting low viscosity. The effect of the nature of initial aldehyde reactant on the hardener properties was studied, as well as the reaction conditions. Then, these pluri-functional amines were added to petro-sourced (diglycidyl ether of bisphenol A, DGEBA) or bio-based (diglycidyl ether of vanillin alcohol, DGEVA) epoxy monomers to form thermosets by step growth polymerization. Due to their low viscosity, the epoxy-amine mixtures were easily homogenized and cured more rapidly compared to the use of more viscous hardeners (<0.6 Pa s at 22 °C). After curing, the thermo-mechanical properties of the epoxy thermosets were determined and compared. The isophthalatetetramine (IPTA) hardener, with a higher number of amine active H, led to thermosets with higher thermo-mechanical properties (glass transition temperatures (Tg and Tα) were around 95 °C for DGEBA-based thermosets against 60 °C for DGEVA-based thermosets) than materials from benzylamine (BDA) or furfurylamine (FDA) that contained less active hydrogens (Tg and Tα around 77 °C for DGEBA-based thermosets and Tg and Tα around 45 °C for DGEVA-based thermosets). By comparing to industrial hardener references, IPTA possesses six active hydrogens which obtain high cross-linked systems, similar to industrial references, and longer molecular length due to the presence of two alkyl chains, leading respectively to high mechanical strength with lower Tg.
Dynamics Contributions to the Growth Mechanism of Ga2O3 Thin Film and NWs Enabled by Ag Catalyst
Authors: Alhalaili Badriyah , Bunk Ryan , Vidu Ruxandra , Islam M. Saif
Published: September 2019

In the last few years, interest in the use of gallium oxide (Ga2O3) as a semiconductor for high power/high temperature devices and UV nano-sensors has grown. Ga2O3 has an enormous band gap of 4.8 eV, which makes it well suited for applications in harsh environments. In this work, we explored the effect of Ag thin film as a catalyst to grow gallium oxide. The growth of gallium oxide thin film and nanowires can be achieved by heating and oxidizing pure gallium at high temperatures (~1000 °C) in the presence of trace amounts of oxygen. We present the results of structural, morphological, and elemental characterization of the β-Ga2O3 thin film and nanowires. In addition, we explore and compare the sensing properties of the β-Ga2O3 thin film and nanowires for UV detection. The proposed process can be optimized to a high scale production Ga2O3 nanocrystalline thin film and nanowires. By using Ag thin film as a catalyst, we can control the growth parameters to obtain either nanocrystalline thin film or nanowires.
Characteristics of p-Type Conduction in P-Doped MoS2 by Phosphorous Pentoxide during Chemical Vapor Deposition
Authors: Lee Jae Sang , Park Chang-Soo , Kim Tae Young , Kim Yoon Sok , Kim Eun Kyu
Published: September 2019

We demonstrated p-type conduction in MoS2 grown with phosphorous pentoxide via chemical vapor deposition (CVD). Monolayer MoS2 with a triangular shape and 15-µm grains was confirmed by atomic force microscopy. The difference between the Raman signals of the A1g and E12g modes for both the pristine and P-doped samples was 19.4 cm−1. In the X-ray photoelectron spectroscopy results, the main core level peaks of P-doped MoS2 downshifted by about 0.5 eV to a lower binding energy compared to the pristine material. Field-effect transistors (FETs) fabricated with the P-doped monolayer MoS2 showed p-type conduction with a field-effect mobility of 0.023 cm2/V⋅s and an on/off current ratio of 103, while FETs with the pristine MoS2 showed n-type behavior with a field-effect mobility of 29.7 cm2/V⋅s and an on/off current ratio of 105. The carriers in the FET channel were identified as holes with a concentration of 1.01 × 1011 cm−2 in P-doped MoS2, while the pristine material had an electron concentration of 6.47 × 1011 cm−2.
Advanced Synchrotron Radiation Techniques for Nanostructured Materials
Authors: Battocchio Chiara
Published: September 2019

Nanostructured materials exploit physical phenomena and mechanisms that cannot be derived by simply scaling down the associated bulk structures and behaviors; furthermore, new quantum effects come into play in nanosystems [...]
Self-Assembled Metal–Organic Biohybrids (MOBs) Using Copper and Silver for Cell Studies
Authors: Karekar Neha , Karan Anik , Khezerlou Elnaz , Prajapati Neela , Pernici Chelsea D. , Murray Teresa A. , DeCoster Mark A.
Published: September 2019

The novel synthesis of metal-containing biohybrids using self-assembly methods at physiological temperatures (37 °C) was compared for copper and silver using the amino acid dimer cystine. Once assembled, the copper containing biohybrid is a stable, high-aspect ratio structure, which we call CuHARS. Using the same synthesis conditions, but replacing copper with silver, we have synthesized cystine-capped silver nanoparticles (AgCysNPs), which are shown here to form stable colloid solutions in contrast to the CuHARS, which settle out from a 1 mg/mL solution in 90 min. Both the copper and silver biohybrids, as synthesized, demonstrate very low agglomeration which we have applied for the purpose of applications with cell culture methods, namely, for testing as anti-cancer compounds. AgCysNPs (1000 ng/mL) demonstrated significant toxicity (only 6.8% viability) to glioma and neuroblastoma cells in vitro, with concentrations as low as 20 ng/mL causing some toxicity. In contrast, CuHARS required at least 5 μg/mL. For comparative purposes, silver sulfate at 100 ng/mL decreased viability by 52% and copper sulfate at 100 ng/mL only by 19.5% on glioma cells. Using these methods, the novel materials were tested here as metal–organic biohybrids (MOBs), and it is anticipated that the functionalization and dynamics of MOBs may result in building a foundation of new materials for cellular applications, including cell engineering of both normal and diseased cells and tissue constructs.
Selective Dye Adsorption by Zeolitic Imidazolate Framework-8 Loaded UiO-66-NH2
Authors: Zhang Hao , Shi Xiaobo , Li Jialiang , Kumar Parveen , Liu Bo
Published: September 2019

In this study, Zeolitic Imidazolate Framework-8 (ZIF-8)-loaded UiO-66-NH2 was synthesized, characterized, and analyzed for its potential to efficiently remove dyes. The selective adsorption on ZIF-8-loaded UiO-66-NH2 or its parent MOFs (UiO-66-NH2 and ZIF-8) in the mixed dyes solution was explored, including anionic dye (methyl orange (MO)) and cationic dyes (methylene blue (MB) and rhodamine B (RhB)). ZIF-8-loaded UiO-66-NH2 displayed much better selectivity to MB than its parent MOFs. Adsorption capacity of ZIF-8-loaded UiO-66-NH2 (173 mg/g) toward MB was found to be 215% higher than UiO-66-NH2 (55 mg/g). A kinetics study based on adsorption data demonstrated that the adsorption process most closely matched with the model of pseudo-second-order kinetic and Langmuir isotherm. The adsorption was an exothermic and spontaneous physical process as revealed by the values of thermodynamic parameters. Furthermore, reusability of ZIF-8-loaded UiO-66-NH2 was investigated and revealed the significant regeneration efficiency in adsorption capacity for MB even after four adsorption cycles. Experimental results proved that the interaction between ZIF-8-loaded UiO-66-NH2 and MB was mainly affected by the mechanism, for instance, electrostatic interaction as well as π–π stacking interactions.
Effective Oxygen Reduction Reaction Performance of FeCo Alloys In Situ Anchored on Nitrogen-Doped Carbon by the Microwave-Assistant Carbon Bath Method and Subsequent Plasma Etching
Authors: Liu Mincong , Yu Feng , Ma Cunhua , Xue Xueyan , Fu Haihai , Yuan Huifang , Yang Shengchao , Wang Gang , Guo Xuhong , Zhang Lili
Published: September 2019

Electrocatalysts with strong stability and high electrocatalytic activity have received increasing interest for oxygen reduction reactions (ORRs) in the cathodes of energy storage and conversion devices, such as fuel cells and metal-air batteries. However, there are still several bottleneck problems concerning stability, efficiency, and cost, which prevent the development of ORR catalysts. Herein, we prepared bimetal FeCo alloy nanoparticles wrapped in Nitrogen (N)-doped graphitic carbon, using Co-Fe Prussian blue analogs (Co3[Fe(CN)6]2, Co-Fe PBA) by the microwave-assisted carbon bath method (MW-CBM) as a precursor, followed by dielectric barrier discharge (DBD) plasma treatment. This novel preparation strategy not only possessed a fast synthesis rate by MW-CBM, but also caused an increase in defect sites by DBD plasma treatment. It is believed that the co-existence of Fe/Co-N sites, rich active sites, core-shell structure, and FeCo alloys could jointly enhance the catalytic activity of ORRs. The obtained catalyst exhibited a positive half-wave potential of 0.88 V vs. reversible hydrogen electrode (RHE) and an onset potential of 0.95 V vs. RHE for ORRs. The catalyst showed a higher selectivity and long-term stability than Pt/C towards ORR in alkaline media.
Highly Conductive Carbon Nanotube-Thermoplastic Polyurethane Nanocomposite for Smart Clothing Applications and Beyond
Authors: Lepak-Kuc Sandra , Podsiadły Bartłomiej , Skalski Andrzej , Janczak Daniel , Jakubowska Małgorzata , Lekawa-Raus Agnieszka
Published: September 2019

The following paper presents a simple, inexpensive and scalable method of production of carbon nanotube-polyurethane elastomer composite. The new method enables the formation of fibers with 40% w/w of nanotubes in a polymer. Thanks to the 8 times higher content of nanotubes than previously reported for such composites, over an order of magnitude higher electrical conductivity is also observed. The composite fibers are highly elastic and both their electrical and mechanical properties may be easily controlled by changing the nanotubes content in the composite. It is shown that these composite fibers may be easily integrated with traditional textiles by sewing or ironing. However, taking into account their light-weight, high conductivity, flexibility and easiness of molding it may be expected that their potential applications are not limited to the smart textiles industry.
Worm-Based Alternate Assessment of Probiotic Intervention against Gut Barrier Infection
Authors: Kim Juil , Moon Yuseok
Published: September 2019

The epithelial barrier is the frontline defense against enteropathogenic bacteria and nutrition-linked xenobiotic stressors in the alimentary tract. In particular, enteropathogenic Escherichia coli (EPEC) insults the gut barrier and is increasingly implicated in chronic intestinal diseases such as inflammatory bowel disease. For the efficient development of intervention against barrier-linked distress, the present study provided a Caenorhabditis elegans-based assessment instead of extensive preclinical evaluations using mammalian models. In particular, EPEC infected the gut and shortened the lifespan of C. elegans, which was counteracted by colonization of E. coli strain Nissle 1917 (EcN). In addition to the competitive actions of EcN against EPEC, EcN improved the gut barrier integrity of worms via the Zonula occludens ortholog (Zoo-1) induction, which was verified in the murine infection and colitis model. The worm-based assessment provided a crucial methodology and important insights into the potent chronic events in the human gut barrier after the ingestion of probiotic candidates as a mucoactive dietary or therapeutic agent.
Nutrition Risk Assessment Using the Modified NUTRIC Score in Cirrhotic Patients with Acute Gastroesophageal Variceal Bleeding: Prevalence of High Nutrition Risk and its Independent Prognostic Value
Authors: Tsai Ming-Hung , Huang Hui-Chun , Peng Yun-Shing , Chen Yung-Chang , Tian Ya-Chung , Yang Chih-Wei , Lien Jau-Min , Fang Ji-Tseng , Hou Ming-Chih , Shen Chien-Heng , Huang Chung-Chi , Wu Cheng-Shyong , Lee Fa-Yauh
Published: September 2019

Malnutrition is associated with adverse outcomes in patients with liver cirrhosis. Relevant data about nutrition risk in critically ill cirrhotic patients are lacking. The modified Nutrition Risk in Critically Ill (mNUTRIC) score is a novel nutrition risk assessment tool specific for intensive care unit (ICU) patients. This retrospective study was conducted to evaluate the prevalence and prognostic significance of nutrition risk in cirrhotic patients with acute gastroesophageal variceal bleeding (GEVB) using mNUTRIC scores computed on admission to the intensive care unit. The major outcome was 6-week mortality. One-hundred-and-thirty-one admissions in 120 patients were analyzed. Thirty-eight percent of cirrhotic patients with acute GEVB were categorized as being at high nutrition risk (a mNUTRIC score of ≥5). There was a significantly progressive increase in mortality associated with the mNUTRIC score (χ2 for trend, p < 0.001). By using the area under a receiver operating characteristic (ROC) curve, the mNUTRIC demonstrated good discriminative power to predict 6-week mortality (AUROC 0.859). In multivariate analysis, the mNUTRIC score was an independent factor associated with 6-week mortality. In conclusion, the mNUTRIC score can serve as a tool to assess nutrition risk in cirrhotic patients with acute GEVB.
Advanced Formulation Approaches for Ocular Drug Delivery: State-Of-The-Art and Recent Patents
Authors: Souto Eliana B. , Dias-Ferreira João , López-Machado Ana , Ettcheto Miren , Cano Amanda , Camins Espuny Antonio , Espina Marta , Garcia Maria Luisa , Sánchez-López Elena
Published: September 2019

The eye presents extensive perspectives and challenges for drug delivery, mainly because of the extraordinary capacity, intrinsic to this path, for drugs to permeate into the main circulatory system and also for the restrictions of the ocular barriers. Depending on the target segment of the eye, anterior or posterior, the specifications are different. The ocular route experienced in the last decades a lot of progresses related with the development of new drugs, improved formulations, specific-designed delivery and even new routes to administer a drug. Concomitantly, new categories of materials were developed and adapted to encapsulate drugs. With such advances, a multiplicity of parameters became possible to be optimized as the increase in bioavailability and decreased toxic effects of medicines. Also, the formulations were capable to easily adhere to specific tissues, increase the duration of the therapeutic effect and even target the delivery of the treatment. The ascending of new delivery systems for ocular targeting is a current focus, mainly because of the capacity to extend the normal time during which the drug exerts its therapeutic effect and, so, supplying the patients with a product which gives them fewer side effects, fewer number of applications and even more effective outcomes to their pathologies, surpassing the traditionally-used eye drops. Depending on the systems, some are capable of increasing the duration of the drug action as gels, emulsions, prodrugs, liposomes, and ocular inserts with hydrophilic properties, improving the absorption by the cornea. In parallel, other devices use as a strategy the capacity to sustain the release of the carried drugs by means of erodible and non-erodible matrices. This review discusses the different types of advanced formulations used for ocular delivery of therapeutics presenting the most recent patents according to the clinical applications.
Spray-Dried Amorphous Solid Dispersions of Atorvastatin Calcium for Improved Supersaturation and Oral Bioavailability
Authors: Kwon Jaewook , Giri Bhupendra Raj , Song Eon Soo , Bae Jinju , Lee Junseong , Kim Dong Wuk
Published: September 2019

Over the past few decades, the amorphous solid dispersions (ASDs) technique has emerged as a promising strategy to enhance the in vitro/in vivo characteristic of hydrophobic drugs. The low aqueous solubility and poor bioavailability of atorvastatin calcium (ATO), a lipid-lowering drug, present challenges for effective drug delivery. The objective of this work was to improve the aqueous solubility, in vitro dissolution, and oral absorption of ATO with amorphous solid dispersion technique prepared by spray-drying method. The optimized ternary formulation comprising of ATO; hydroxypropyl methylcellulose (HPMC), as a hydrophilic polymer; and sodium lauryl sulfate (SLS), as a surfactant, at a weight ratio of 1/1/0.1, showed significant improvement in aqueous solubility by ~18-fold compared to that of the free drug, and a cumulative release of 94.09% compared to a release of 59.32% of the free drug. Further, physicochemical studies via scanning electron microscopy, differential scanning calorimetry, and powder X-ray diffraction revealed a change from the crystalline state of the free drug to its amorphous state in the ASD. Pharmacokinetic analysis in rats demonstrated 1.68- and 2.39-fold increments in AUC and Cmax, respectively, in the ASD over the free drug. Altogether, hydrophilic carrier-based ASDs prepared by the spray-drying technique represent a promising strategy to improve the biopharmaceutical performance of poorly soluble drugs.
Oxidation- and Temperature-Responsive Poly(hydroxyethyl acrylate-co-phenyl vinyl sulfide) Micelle as a Potential Anticancer Drug Carrier
Authors: Kim Tae Hoon , Alle Madhusudhan , Kim Jin-Chul
Published: September 2019

Poly(hydroxyethyl acrylate-co-phenyl vinyl sulfide) (P(HEA-co-PVS)), as an oxidizable amphiphilic polymer, was prepared for the fabrication of an oxidation- and temperature-responsive micelle for the delivery of doxorubicin (DOX). The interfacial activity of H2O2-treated P(HEA-co-PVS) was significantly lower than that of the untreated variety, possibly because of the oxidization of PVS. P(HEA-co-PVS) exhibited a lower critical solution temperature (LCST) behavior and the LCST increased upon H2O2 treatment. The copolymer micelles, prepared by the dialysis method, were found to be round particles (less than 100 nm) on TEM micrograph. The release degree of Nile red loaded in the micelles was higher when the H2O2 concentration was higher, possibly because the micelles could be solubilized more readily at a higher H2O2 concentration. The release degree was more strongly dependent on the oxidizing agent concentration when the temperature was higher. DOX loaded in the micelles suppressed the in vitro growth of KB cells (a human cancer cell type originating from the cervix) much more effectively than DOX loaded in an unoxidizable control micelle and free DOX, possibly because the copolymer would undergo an increase in its LCST, lose its amphiphilic property, and the micelles would be disassembled. The DOX-loaded micelles were readily internalized into KB cells, as evidenced by flow cytometry (FACS) and confocal laser scanning microscopy (CLSM).
Epoxy Resins for Negative Tone Photoresists
Authors: Vlnieska Vitor , Mikhaylov Andrey , Zakharova Margarita , Blasco Eva , Kunka Danays
Published: September 2019

One of the types of negative tone photoresists is composed of at least a catalyst, a solvent, and epoxy resin. This is the primary raw material for lithography technology. To ensure high-quality pattern transfer in the lithography process, it is crucial to control the properties of the photoresist. In this work, a set of resins based on Bisphenol-A were synthesized. The obtained resins have been characterized regarding the chain size and its derivative products. As a second step, an epoxidation reaction was performed and the epoxy groups were quantified. The profile of the resins, obtained by mass spectroscopy (ESI-µ-TOF-MS), showed that it is possible to tune the chain sizes of the polymers and their derivate by controlling the parameters of the polymerization reaction. Three profiles of resins were achieved in this study. Nuclear magnetic resonance (NMR) indicates an epoxidation in the range of 96%, when comparing the phenolic peak intensity before and after the reaction. Differential Scan Calorimetry (DSC) measurements confirmed the different oligomer profiles of resins, showing different glass transition temperatures.
Thioetherimide-Modified Cyanate Ester Resin with Better Molding Performance for Glass Fiber Reinforced Composites
Authors: Ma Pengchang , Dai Chuntao , Jiang Shaohua
Published: September 2019

Cyanate ester (CE) resins with higher heat resistance, lower coefficients of thermal expansion (CTEs), and lower water absorption ratios are highly desired in printed circuit boards (PCBs). In this work, a CE was modified by copolymerization with a long-chain thioether bismaleimide (SBMI) to form a thioetherimide-modified CE (SBT). The results indicated that SBT had a wider processing window and better processing properties than a common bismaleimide-modified CE resin (MBMI). After molding with a glass fiber cloth, the composites (GSBT) exhibited moisture adsorption in the range of 1.4%–2.0%, high tensile strength in the range of 311–439 MPa, good mechanical retention of 70%–85% even at 200 °C, and good dimension stability, with coefficients of thermal expansion in the range of 17.3–18.6 (×10−6 m/°C). Such GSBT composites with superior properties would be good candidates for PCB applications.
Synthesis and Photovoltaic Effect of Electron-Withdrawing Units for Low Band Gap Conjugated Polymers Bearing Bi(thienylenevinylene) Side Chains
Authors: Li Jianfeng , Wang Yufei , Wang Ningning , Liang Zezhou , Wang Xu , Peng Yichun , Tong Junfeng , Yang Chunyan , Xia Yangjun
Published: September 2019

A novel (E)-5-(2-(5-alkylthiothiophen-2-yl)vinyl)thien-2-yl (TVT)-comprising benzo[1,2-b:4,5-b’]dithiophene (BDT) derivative (BDT-TVT) was designed and synthetized to compose two donor-acceptor (D-A) typed copolymers (PBDT-TVT-ID and PBDT-TVT-DTNT) with the electron-withdrawing unit isoindigo (ID) and naphtho[1,2-c:5,6-c′]bis[1,2,5]thiadiazole (NT), respectively. PBDT-TVT-ID and PBDT-TVT-DTNT showed good thermal stability (360 °C), an absorption spectrum from 300 nm to 760 nm and a relatively low lying energy level of Highest Occupied Molecular Orbital (EHOMO) (−5.36 to –5.45 eV), which could obtain a large open-circuit voltage (Voc) from photovoltaic devices with PBDT-TVT-ID or PBDT-TVT-DTNT. The photovoltaic devices with ITO/PFN/polymers: PC71BM/MoO3/Ag structure were assembled and exhibited a good photovoltaic performance with a power conversion efficiency (PCE) of 4.09% (PBDT-TVT-ID) and 5.44% (PBDT-TVT-DTNT), respectively. The best PCE of a PBDT-TVT-DTNT/PC71BM-based device mainly originated from its wider absorption, higher hole mobility and favorable photoactive layer morphology.
Thermal Conductivity of Polyamide-6,6/Carbon Nanotube Composites: Effects of Tube Diameter and Polymer Linkage between Tubes
Authors: Keshtkar Mahboube , Mehdipour Nargess , Eslami Hossein
Published: September 2019

Reverse nonequilibrium molecular dynamics simulations were done to quantify the effect of the inclusion of carbon nanotubes (CNTs) in the Polyamide-6,6 matrix on the enhancement in the thermal conductivity of polymer. Two types of systems were simulated; systems in which polymer chains were in contact with a single CNT, and those in which polymer chains were in contact with four CNTs, linked together via polymer linkers at different linkage fractions. In both cases, heat transfer in both perpendicular and parallel (to the CNT axis) directions were studied. To examine the effect of surface curvature (area) on the heat transfer between CNT and polymer, systems containing CNTs of various diameters were simulated. We found a large interfacial thermal resistance at the CNT-polymer boundary. The interfacial thermal resistance depends on the surface area of the CNT (lower resistances were seen at the interface of flatter CNTs) and is reduced by linking CNTs together via polymer chains, with the magnitude of the reduction depending on the linkage fraction. The thermal conductivity of polymer in the perpendicular direction depends on the surface proximity; it is lower at closer distances to the CNT surface and converges to the bulk value at distances as large as 2 nm. The chains at the interface of CNT conduct heat more in the parallel than in the perpendicular directions. The magnitude of this thermal conductivity anisotropy reduces with decreasing the CNT diameter and increasing the linkage fraction. Finally, microscopic parameters obtained from simulations were used to investigate macroscopic thermal conductivities of polymer nanocomposites within the framework of effective medium approximation.
Model-Based Grasping of Unknown Objects from a Random Pile
Authors: Sauvet Bruno , Lévesque François , Park SeungJae , Cardou Philippe , Gosselin Clément
Published: September 2019

Grasping an unknown object in a pile is no easy task for a robot—it is often difficult to distinguish different objects; objects occlude one another; object proximity limits the number of feasible grasps available; and so forth. In this paper, we propose a simple approach to grasping unknown objects one by one from a random pile. The proposed method is divided into three main actions—over-segmentation of the images, a decision algorithm and ranking according to a grasp robustness index. Thus, the robot is able to distinguish the objects from the pile, choose the best candidate for grasping among these objects, and pick the most robust grasp for this candidate. With this approach, we can clear out a random pile of unknown objects, as shown in the experiments reported herein.
Fashion Brand Love: Application of a Cognition–Affect–Conation Model
Authors: Han Tae-Im , Choi Dooyoung
Published: September 2019

A large numbers of studies have supported the crucial role of brand love in consumer–brand relationships; however, research that examines fashion brand love and its relationship with cognitive aspects and self-concept congruency remains limited. Therefore, the purpose of this study was to identify important factors that are associated with fashion brand love. A questionnaire in which participants provided self-reported responses was created to measure the constructs and structural equation modeling (SEM) and independent sample t-tests were conducted to test the hypothesized relationships. Our results indicated that consumers who know more about fashion brands are more likely to have stronger emotional attachment to their favorite fashion brand and brand love, in turn, has a significant effect on performing brand-loyal behaviors. Furthermore, our results demonstrated that fashion brand love is strongly associated with actual and ideal self-congruity. These findings suggest that it is important for fashion brands to focus on developing affective relationships with consumers to gain brand loyalty and one way to achieve this goal is to enhance brand awareness or knowledge among consumers. Fashion brands also need to invest in activities that aim to deliver a brand image congruent with actual and ideal self-concepts of the target market.
An Approach for Describing the Effects of Grazing on Soil Quality in Life-Cycle Assessment
Authors: Roesch Andreas , Weisskopf Peter , Oberholzer Hansruedi , Valsangiacomo Alain , Nemecek Thomas
Published: September 2019

Describing the impact of farming on soil quality is challenging, because the model should consider changes in the physical, chemical, and biological status of soils. Physical damage to soils through heavy traffic was already analyzed in several life-cycle assessment studies. However, impacts on soil structure from grazing animals were largely ignored, and physically based model approaches to describe these impacts are very rare. In this study, we developed a new modeling approach that is closely related to the stress propagation method generally applied for analyzing compaction caused by off-road vehicles. We tested our new approach for plausibility using a comprehensive multi-year dataset containing detailed information on pasture management of several hundred Swiss dairy farms. Preliminary results showed that the new approach provides plausible outcomes for the two physical soil indicators “macropore volume” and “aggregate stability”.
Towards Sustainable Development and Preventing Exclusions—Determining Road Accessibility at the Sub-Regional and Local Level in Rural Areas of Poland
Authors: Wolny Ada , Ogryzek Marek , Źróbek Ryszard
Published: September 2019

The improvement in a regions’ accessibility that accounts for various means of inter-regional transport and inter-regional communication is one of the main determinants of sustainable regional development. This study focuses on road accessibility in rural areas where an insufficient number and scope of international and domestic investments can lead to an imbalance in the transport infrastructure. Therefore, the aim of this study was to evaluate road accessibility at the level of the NUTS4 units in view of their sustainable development and their divergence from rural units that are less distant from the main transport routes. The studied area—a province—is situated in the northeast of Poland. Data concerning the travel time, condition, and density of the road network were analysed to develop and compare the measures of road accessibility in individual units and to perform an overall assessment of the NUTS4 units. Partial indices were calculated with the support of the QGIS and ArcGIS software. Peripheral regions in post-socialist countries appear to be particularly underinvested in terms of the transport, including at the local and regional level. The applied methodology supported the presentation of problem peripheral areas that are underinvested and threatened with exclusion.
Exports, Misallocation, and Total Factor Productivity of Furniture Enterprises
Authors: Xu Chang , Guo Jianbing , Cheng Baodong , Liu Yu
Published: September 2019

With the increase in labor costs in China and the tremendous changes in the international trade environment, upgrading the total factor productivity of Chinese furniture export enterprises faces a great challenge. Lots of studies have explored the interaction of exports or misallocation on the total factor productivity (TFP) of furniture enterprises, however, there is little knowledge on the impact and interaction of both exports and misallocation on the TFP. Based on panel data of Chinese furniture enterprises, this paper measures the TFP and the distortion of labor and capital resources in Chinese furniture enterprises. A two-way fixed-effects model is used to analyze the impact of exports and misallocation on the TFP of Chinese furniture enterprises. The paper reveals several important findings. First, the TFP of Chinese furniture export enterprises is lower than that of non-export enterprises, this phenomenon is called the “export–productivity paradox”. Chinese furniture export enterprises are processing trade-oriented and labor-intensive enterprises at the low end of the value chain, exports have a negative effect on improving the TFP of furniture enterprises in the short term. Second, the distortion of labor and capital resources in Chinese furniture enterprises promotes improvements to the TFP of furniture enterprises rather than reducing the TFP of furniture enterprises. Last but not the least, we find that misallocation has a positive moderating effect on exports and can weaken the negative impact of exports on TFP by the “forced mechanism”, which is that the higher the distortion of the misallocation, the higher the cost of acquiring capital and labor, and enterprises are forced to enhance their productivity when facing market competition, thus promoting improvements to the TFP of furniture enterprises.
Placing Transdisciplinarity in Context: A Review of Approaches to Connect Scholars, Society and Action
Authors: Knapp Corrine Nöel , Reid Robin S. , Fernández-Giménez María E. , Klein Julia A. , Galvin Kathleen A.
Published: September 2019

Complex sustainability problems (e.g., climate change) are challenging to understand and manage, leading to an increase in approaches that connect scholars to society and research to action (collaborative approaches). The transdisciplinary approach (TDA) represents one such approach. While TDA is new to many, there are several prior collaborative approaches including collaborative adaptive management, knowledge integration, participatory action research, and indigenous/local knowledge. Other contemporary and parallel approaches include citizen science, translational science, evidence-based practice, and knowledge with action. The varied disciplinary roots and problem areas contribute to a lack of interaction among these parallel but distinct approaches, and among the scholars and stakeholders who practice them. In this paper, we consider the connections, complementarities and contradictions among these distinct but related collaborative approaches. This review offers insights into the interaction between science and practice, including the importance of social processes and recognition of different ways of knowing, as well as how to conduct collaborative approaches on a variety of scales and think about how to generalize findings. The review suggests a need to rethink roles and relationships in the process of knowledge co-creation, both extending the roles of researchers and practitioners, creating new hybrid roles for “pracademics”, and placing greater awareness on issues of power.
Land Use Transition and Its Influencing Factors in Poverty-Stricken Mountainous Areas of Sangzhi County, China
Authors: Xie Wenhai , Jin Wanfu , Chen Kairui , Wu Jilin , Zhou Chunshan
Published: September 2019

Previous studies have rarely revealed the characteristics and influencing factors of land use transformation (LUT) in poverty-stricken areas, where multiple actions of cultivated land protection are undertaken. The land use conversion matrix and Spatial Durbin Model were used to analyze the characteristics and influence factors of LUT based on remote sensing interpretation data of Sangzhi County in 2010, 2015, and 2018. The results demonstrate the following: (1) From 2010–2018, cultivated land, forest land, waters, and urban and rural construction land in Sangzhi County increased by 4.91%, 0.03%, 58.99%, and 55.63%, respectively, and grassland decreased by 13.32%. (2) Terrain, territorial, and traffic conditions were common influence factors of the land use type conversion (i.e., forest land to cultivated land, grassland to forest land, cultivated land to forest land, grassland to cultivated land, and cultivated land to urban and rural construction land). The conversion of land use type has a negative effect on the land use type conversion of adjacent townships. Territorial and traffic conditions affect the land use type conversion of adjacent townships. The results illuminate LUT at the township scale in mountainous areas and are beneficial to promoting the sustainable use of land resources and poverty alleviation.
Quantifying Impacts of Urban Microclimate on a Building Energy Consumption—A Case Study
Authors: Liu Jiying , Heidarinejad Mohammad , Nikkho Saber Khoshdel , Mattise Nicholas W. , Srebric Jelena
Published: September 2019

This paper considered an actual neighborhood to quantify impacts of the local urban microclimate on energy consumption for an academic building in College Park, USA. Specifically, this study accounted for solar irradiances on building and ground surfaces to evaluate impacts of the local convective heat transfer coefficient (CHTC), infiltration rate, and coefficient of performance (COP) on building cooling systems. Using computational fluid dynamics (CFD) allowed for the calculation of local temperature and velocity values and implementation of the local variables in the building energy simulation (BES) model. The discrepancies among the cases with different CHTCs showed slight influence of CHTCs on sensible load, in which the maximum variations existed 1.95% for sensible cooling load and 3.82% for sensible heating load. The COP analyses indicated windward wall and upstream roof are the best locations for the installation of these cooling systems. This study used adjusted infiltration rate values that take into account the local temperature and velocity. The results indicated the annual cooling and heating energy increased by 2.67% and decreased by 2.18%, respectively.
Template-Free Synthesis of a Phenanthroline-Containing [2]Rotaxane: A Reversible pH-Controllable Molecular Switch
Authors: Muraoka Masahiro , Aoyama Kakeru , Fujihara Sae , Yamane Risa , Hisaki Ichiro , Miyata Mikiji , Murata Michihisa , Nakatsuji Yohji
Published: September 2019

The synthesis of symmetric and asymmetric rotaxanes consisting of neutral axle and ring components without ionic templates is necessary for applications in molecular sensors and molecular switches. A phenanthroline-containing symmetric [2]rotaxane was newly synthesized by inducing hydrogen bonding and π-interaction using a template-free threading-followed-by-stoppering method. The obtained rotaxane serves as a reversible pH-controllable molecular switch.
Pathogenic Leptospira in Commensal Small Mammals from the Extensively Urbanized Coastal Benin
Authors: Houéménou Gualbert , Gauthier Philippe , Etougbétché Jonas , Badou Sylvestre , Dossou Henri-Joël , Agossou David , Picardeau Mathieu , Dobigny Gauthier
Published: September 2019

Leptospirosis is caused by spirochete bacteria of the genus Leptospira that affect one million and kill 60,000 persons annually in the world, who get infected through environmental mammal-excreted (notably rodent) pathogens. Using qPCR and DNA sequencing approaches, we here examine Leptospira occurrence and diversity in 971 commensal small mammals in urban and peri-urban habitats from south Benin, where socio-environmental conditions are favorable for human contamination. Prevalence reached 12.9% on average, but showed very important variations in both space and time, thus pointing toward a role of local processes in the maintenance and circulation of rodent-borne leptospires in the area. Prevalence peaks may occur during or one month after moderate (100–200 mm) monthly rainfall, suggesting that rodent-borne leptospires may be more prevalent when standing waters are present, but not at their highest levels (i.e., floods). However, this pattern will have to be confirmed through proper diachronic analysis. Finally, an incomplete but significant host-specificity was observed, with L. kirschneri retrieved only in African shrews, and the invasive Rattus norvegicus and the native Mastomys natalensis preferentially infected by L. interrogans and L. borgpeterseni, respectively. Our study highlights the urgent need for investigations on human leptospirosis in the extensively urbanized Abidjan–Lagos corridor.
Brevilin A, a Sesquiterpene Lactone, Inhibits the Replication of Influenza A Virus In Vitro and In Vivo
Authors: Zhang Xiaoli , Xia Yiping , Yang Li , He Jun , Li Yaolan , Xia Chuan
Published: September 2019

With the emergence of drug-resistant strains of influenza A viruses (IAV), new antivirals are needed to supplement the existing counter measures against IAV infection. We have previously shown that brevilin A, a sesquiterpene lactone isolated from C. minima, suppresses the infection of influenza A/PR/8/34 (H1N1) in vitro. Here, we further investigate the antiviral activity and mode of action of brevilin A against different IAV subtypes. Brevilin A inhibited the replication of influenza A H1N1, H3N2, and H9N2 viruses in vitro. The suppression effect of brevilin A was observed as early as 4–8 hours post infection (hpi). Furthermore, we determined that brevilin A inhibited viral replication in three aspects, including viral RNA (vRNA) synthesis, expression of viral mRNA, and protein encoded from the M and NS segments, and nuclear export of viral ribonucleoproteins (vRNPs). The anti-IAV activity of brevilin A was further confirmed in mice. A delayed time-to-death with 50% surviving up to 14 days post infection was obtained with brevilin A (at a dose of 25 mg/kg) treated animals compared to the control cohorts. Together, these results are encouraging for the exploration of sesquiterpene lactones with similar structure to brevilin A as potential anti-influenza therapies.
The Proteolytic Regulation of Virus Cell Entry by Furin and Other Proprotein Convertases
Authors: Izaguirre Gonzalo
Published: September 2019

A wide variety of viruses exploit furin and other proprotein convertases (PCs) of the constitutive protein secretion pathway in order to regulate their cell entry mechanism and infectivity. Surface proteins of enveloped, as well as non-enveloped, viruses become processed by these proteases intracellularly during morphogenesis or extracellularly after egress and during entry in order to produce mature virions activated for infection. Although viruses also take advantage of other proteases, it is when some viruses become reactive with PCs that they may develop high pathogenicity. Besides reacting with furin, some viruses may also react with the PCs of the other specificity group constituted by PC4/PC5/PACE4/PC7. The targeting of PCs for inhibition may result in a useful strategy to treat infections with some highly pathogenic viruses. A wide variety of PC inhibitors have been developed and tested for their antiviral activity in cell-based assays.
Serum LPS Associated with Hantavirus and Dengue Disease Severity in Barbados
Authors: Douglas Kirk , Samuels Thelma , Gittens-St. Hilaire Marquita
Published: September 2019

Hantavirus and dengue virus (DENV) infections are caused by RNA viruses which infect immune systems’ cells including monocytes, macrophages and dendritic cells and occur year-round in Barbados. A retrospective serological study (2008–2015) was conducted on hantavirus and dengue patient sera confirmed by IgM and IgG ELISA, NS1 and RT-PCR using Limulus amoebocyte lysate (LAL) kinetic turbidimetric method to determine serum endotoxin levels. Hantavirus patients were categorized into two groups, namely (a) hospitalized and (b) non-hospitalized. Dengue patients were categorized into 3 groups using 2009 WHO dengue guidelines (a) severe dengue (SD), (b) hospitalized non-severe dengue (non-SD) and (c) non-hospitalized non-SD. Statistical analyses were conducted to determine the association of endotoxin levels with hantavirus disease severity based on hospitalization and dengue disease severity. Serum endotoxin levels are associated with hantavirus disease severity and hospitalization and dengue disease severity (p < 0.01). Similar studies have found an association of serum endotoxin levels with dengue disease severity but never with hantavirus infection. Co-detection of hantavirus- and DENV-specific IgM in some patients were observed with elevated serum endotoxin levels. In addition, previous studies observed hantavirus replication in the gut of patients, gastrointestinal tract as a possible entry route of infection and evidence of microbial translocation and its impact on hantavirus disease severity. A significant correlation of serum endotoxin and hantavirus disease severity and hospitalization in hantavirus infected patients is reported for the first time ever. In addition, serum endotoxin levels correlated with dengue disease severity. This study adds further support to the role of endotoxin in both hantavirus and dengue virus infection and disease severity and its role as a possible therapeutic target for viral haemorrhagic fevers (VHFs).