bluuebunny/crossref_metadata_2025 huggingface dataset:
Diversity, Equity, and Inclusion (DEI) Statements in the U. S. Creative Sector: Progress, or More Bullshit?
Authors: Cuyler Antonio C.
Published: January 2022

This article represents a snapshot and analysis of U. S. service arts organizations’ DEI statements and activities in 2018. At that time, many primarily White-serving U. S. cultural organizations responded defensively to accusations of elitism and a harmful rigged funding system that maintained the status quo by awarding most cultural funding to these organizations while undermining the health and vitality of cultural organizations by and for historically oppressed communities (Sidford, 2011). Furthermore, Helicon Collaborative (2017) found that even with a host of cultural equity, “diversity” projects (Tseng 2016), and public-facing DEI statements, little had changed within six years. Therefore, this study uses directed and summative content analysis to investigate the research question “what do cultural equity and diversity statements communicate about cultural organizations’ positions on DEI?” This study also uses Frankfurt’s (2005) essay On Bullshit and Laing’s (2016) two-prong definition of accountability as a theoretical framework to examine if and how cultural organizations hold themselves accountable for achieving DEI in the creative sector. Lastly, readers should keep in mind that the public murder of Geor-ge Floyd in 2020 has hastened all of the service arts organizations’ access, diversity, equity, and inclusion (ADEI) work examined in this study.
Art and Communication: A Look to the Art Market
Authors: Pla Adria Harillo
Published: January 2022

This text presents a communicative model in the art market as well as its importance compared to the traditional communication model analysed from Art History. To achieve this, we expose the lack of solid criteria when defining what art is. Subsequently, we defend that the Sociology of Language allows us to obtain a referential and pragmatic knowledge of what a community calls art. As we will say, this lan-guage is produced through money, and that is why Economic Sociology plays a key role. Understanding that “art” is something named like this in a social environment with its agents, motivations and mecha-nisms, we defend that the art market - as a small part of the art world - is a tool of great informative value. This is because it allows to see what a human group refers to as “art”. This is possible thanks to the use of a shared code (money). Through money, some agents can express their preferences in that context, acting as senders. The market plays the channel role and, the public acts as the receiver. The preferences shown through money by some agents within that social system gives to the community some referential and pragmatic knowledge while allowing us to allocate that scarce resource named “art”.
Cultural Determinants of Business Negotiations and Behaviors
Authors: Maciejewski Grzegorz
Published: January 2022

The paper is a theoretical and empirical study on the cultural determinants of business negotiations and behaviors. The theoretical aim of the paper is to present the main models used to study and compare national cultures. The applicable purpose of the paper is to present the results of a comparative analysis of individual cultures of the business world based on the six dimensions of national culture described in Hofstede’s model. The paper is based on the literature and Hofstede Insights data. A comparative analy-sis of data from 118 countries, from all continents, was carried out. Then, based on the cluster analysis, 16 groups of countries – the cultures of the business world – were distinguished and characterized. The obtained results constitute an original contribution to the study of understanding the differences and similarities of individual national cultures. They can also be of value for both scientists pursuing intercul-tural research and business people who conduct their business in various regions of the world.
РОЗРОБКА ІНФОРМАЦІЙНОЇ МОДЕЛІ МОНІТОРИНГУ ЕКОСИСТЕМИ
Authors: ASTISTOVA TETYANA
Published: January 2022

Goal. Development of an information model for monitoring ecosystem data obtained from facilities to identify deviations from the standard, in real time, at a distance and make decisions to eliminate themMethodology. The development of the system was based on the Minimum viable product with minimal functionality. and the minimum cost of resources. The concept of system development is considered on the example of a reasonable dormitory, where one of the components of the system is the Internet of Things technology, in which different device connect to the Internet and interact with each other. The sensors allow the device to send data to a computer program that will collect and analyze it. This will allow you to effectively identify the problem in the event of deviations from the standard during the operation of s and will facilitate the prediction of possible accidents, malfunctions and their elimination.Results. Based on the analysis of the characteristics of microcontrollers and sensors, a wireless communication module installed in the device of the monitoring system was selected, and types of sensors were selected for collecting and further analysis of ecosystem indicators The structural elements of the subsystem and the code for the example of the board for the sensor have been developed. To implement the task, the open programming language Processing and development tools were chosen that would satisfy all the requirements and have the necessary functionality. TelegramBot was chosen as the interface for the ecosystem's automated storage database concepts. To connect hardware devices, APIs and Internet services, Node-RED was chosen as the programming tool. To write the bot, the RedBot package for NodeRED was used.Scientific novelty. An original solution is proposed for the development of an information model of ecosystem indicators in premises based on the element base of the selected monitoring module, communication protocols and an interface for interacting with the user through a chat bot.Practical significance. The system was tested on data obtained in the hostel KNUTD in may 2021. This environment is hosted on Amazon Web Services (AWS) EC2The test results showed the system's operability, the ability to receive and analyze information in real time and quickly respond to dangerous situations. All this will improve the life of students in the hostel and ensure themselves and their health from the influence of negative factors.
П’ЄЗОДАТЧИК ЯК ЕЛЕМЕНТ УПРАВЛІННЯ СВІТЛОМ ДЛЯ СТВОРЕННЯ ДИЗАЙНУ ДИТЯЧОГО ПРИМІЩЕННЯ
Authors: DZIKEVYCH ANNA , OLEINIKOVA IRYNA
Published: January 2022

Purpose. Substantiation and creation of automatic lighting control in interactive rooms using piezoelectric converters. The introduction of this technology will significantly reduce energy consumption during the operation of such premises. The addition of further technological solutions based on the use of phosphor coatings and ultraviolet lighting will create a full range of innovative methods of child interaction in the social space.Methodology. The combination of piezo sensors with design elements such as "live" tiles as a trigger mechanism will create the necessary connection between the physical activity of the child and the regulation of light. The modern level of development and complete safety of materials such as phosphors in combination with specially designed point light sources will make it possible to create additional lighting and a field for the imagination of the child. Since the main attention when lighting children's rooms should be directed to the safe stay of the child, the use of light sources under a translucent floor will solve safety issues with a low level of energy consumption.Findings. An experimental study of the methods has proven the feasibility of using the proposed elements for any interactive children's room. The low cost of both equipment and the energy efficiency of all the technologies used is a significant advantage of this project over other developments with a large use of digital gadgets. The ability of create light of different spectral composition and color temperature is analyzed by using color filters and special light sources.Originality. The technologies and techniques presented in this work will be used for the first time to create interactive activities for a child. Separately, each technological solution was applied individually. This project combines separate developments to create a single interactive and light space. A low level of electricity consumption is achieved by using specially designed piezoelectric elements. Replacing standard ceiling lighting with lower (floor) lighting allows you to achieve the desired illumination using luminaires of lower power.Practical value. Recently, it has been proven that digitalization has a negative impact on the emotional state of the child and the only solution to replace it is to switch the child's attention to other more physically active actions. The proposed solutions in the work will allow their to be involved in group trainings. At the same time, the power consumption for obtaining such rooms will be much lower than the rest of the existing ones. The simplicity of the equipment and the possibility of variation during the operation of the premises make it available for creation in any institution of education, medicine, sports, etc.
Facts that Influence College Students’ Reading Motivation
Authors: Huang Suhua , Reynolds Marcie
Published: January 2022

This study investigated American college students’ reading motivation. A total of 1,437 (533 male and 904 female) college students across interdisciplinary areas voluntarily participated in the study by completing a self-reported survey. Two major research questions were addressed in this study. The first question investigated American college students’ reading motivation by the Motivation for Reading Questionnaire (MRQ) variables of self-efficacy, intrinsic motivation, extrinsic motivation, and social motivation. The second question asked what variables influence American college students’ motivation to read by comparing gender, classification, age, race, language backgrounds, grades in major subjects and minor subjects. Descriptive analysis indicated that the mean scores of the extrinsic motivation scale (3.07) were higher than those of intrinsic motivation (3.05), self-efficacy (3.04) and social motivation (2.35) scales. A multiple linear regression statistical analysis confirmed that gender, age, classification, grade, race, and primary language were significant factors in college students’ motivation to read. Keywords: college students, reading motivation, MRQ
Higher Teacher Education: Raising Awareness toward Constructing Teaching Philosophy Statements
Authors: Muthanna Abdulghani
Published: January 2022

This article focuses on exploring whether teacher educators and teacher students at higher teacher education programs have constructed their teaching philosophy statements, how they implement such philosophy statements, and how they develop and evaluate the contents of the teaching materials related to the courses they are instructing. By following the qualitative case study methodology, the author employed semi-structured interviews with twenty teacher educators and fifteen teacher students from one state higher education institution in Yemen. With the employment of thematic network analysis techniques, the findings report on the lack of awareness concerning the teaching philosophy statements construction, the random process of designing and evaluating teaching materials, and the lack of teaching aids for realizing the teaching philosophies of those with developed teaching statements. For practical implementation, university leaders and administrators are recommended to establish a program that focuses on the professional development of the teaching faculty with a focus on highlighting and providing useful knowledge on the ‘teaching philosophy statements’ construction and ‘materials design and evaluation’ processes. Keywords: teaching philosophy, teacher education, higher education, curriculum design, Yemen
APPLICATION OF OJIP CHLOROPHYLL FLUORESCENCE TRANSIENT ANALYSIS TO STUDY THE POSTHARVEST CHANGES IN PHOTOSINTHETIC APPARATUS IN CUT FOLIAGE SPECIES
Authors: Wijethunga W M U D , Jayasooriya L S H , Subasinghe S M J C , Kumarihami H M P C , Beneragama C K
Published: January 2022

Chlorophyll fluorescence (ChlF) is a non-invasive technique that can be potentially used in postharvest research to gain useful information on early responses to postharvest stresses. This study was conducted to validate the application of ChlF transient analysis in determining the postharvest changes in photosynthetic apparatus in three ornamental foliage species, i.e., Cordyline fruticosa ‘Willy’s Gold’ and ‘Rubra’, Dracaena sanderiana ‘White’, and Nephrolepis exaltata. Salicylic acid (100 and 300 mg·L−1), glucose (10 g·L−1), and their combinations were used as holding solutions with control treatment (distilled water) at room temperature (25±2°C). Vase life was evaluated using OJIP analysis. OJIP parameters, i.e., specific energy fluxes per reaction center (ABS/RC, TR/RC, ET/RC, and DI/RC), flux ratios (maximum quantum yield of primary photochemistry-φPo), electron transport efficiency (ψo), and quantum yield of electron transport (φEo), and performance index (PI) were recorded every other day, using a fluorometer (FluorPen 100). Leaf chlorophyll contents of all species and anthocyanin contents of two cordyline cultivars were determined. Data were subjected to ANOVA in a completely randomized design. Mean separation was done by DMRT (p ≤ 0.05). Clear variations in ChlF were observed in every foliage species with the time. OJIP analysis showed species-depended variations. The higher ABS/RC and DI/RC were recorded for D. sanderiana and N. exaltata compared to the PI of those species. At the end of the experiment, the chlorophyll contents were decreased, while anthocyanin contents were increased. Consequently, chlorophyll fluorescence changes in photosynthetic apparatus can be used for the prediction of the postharvest stresses and longevity of cut foliage.
Modernization of work member construction of mobile grinder
Authors:   M. F. Reshetnev Siberian State University of Science and Technologies, Lesosibirsk Branch, Zyryanov M. A. , Mokhirev A. P. ,   M. F. Reshetnev Siberian State University of Science and Technologies, Lesosibirsk Branch, Surnichev V. L. ,   M. F. Reshetnev Siberian State University of Science and Technologies, Lesosibirsk Branch, Semenenko E. A. ,   M. F. Reshetnev Siberian State University of Science and Technologies, Lesosibirsk Branch
Published: January 2022

The process scheme for the processing section of logging waste into semi-finished wood-fiber products is presented. Design features of equipment are described. The solution allowing one to decrease manufacture complexity of work members of a grinder and to increase their maintainability was proposed.
Piezo2—peripheral baroreceptor channel expressed in select neurons of the mouse brain: a putative mechanism for synchronizing neural networks by transducing intracranial pressure pulses
Authors: Wang Jigong , Hamill Owen P.
Published: January 2022

Here we use immunohistochemistry to examine the expression of Piezo2 in neurons of the mouse dorsal root ganglia and brain. Whereas Piezo2 is expressed in the large majority (≥ 90%) of dorsal root ganglia neurons, Piezo2 expression is restricted to select neuron types in specific brain regions, including neocortical and hippocampal pyramidal neurons, cerebellar Purkinje cells and mitral cells of the olfactory bulb. Given the well-established role of Piezo2 as a low-threshold pressure sensor (i.e., ≤5 mmHg) in peripheral mechanosensation, including the regulation of breathing and blood pressure, its expression in central neurons has interesting implications. In particular, we hypothesize that Piezo2 provides neurons with an intrinsic resonance that promotes their entrainment by the normal intracranial pressure pulses (~5 mmHg) associated with breathing and cardiac cycles. The pressure-induced change in neural activity need only be very subtle to increase, for example, the robustness of respiration-entrained oscillations reported previously in widely distributed neuronal networks in both rodent and human brains. This idea of a “global brain rhythm” first arose from the effect of nasal airflow in activating mechanosensitive olfactory sensory neurons, which then synaptically entrain mitral cells within the olfactory bulb and through their projections, neural networks in other brain regions, including the hippocampus and neocortex. Our proposed, non-synaptic, intrinsic mechanism, where Piezo2 tracks the highly predictable and “metronome-like” intracranial pressure pulses—to date generally considered epiphenomena—would have the advantage that a physical force rapidly transmitted throughout the brain also contributes to this synchronization.
Network pharmacology and the experimental findings of Bushenhuoxue formula for improving hippocampal neuron injury in vascular demented rats
Authors: Luo Shan , Jing Jiaxing , Zhang Ying , Yu Wentao , Gao Weijuan
Published: January 2022

We used network pharmacology to predict the correlation between the pathway of Bushenhuoxue formula in the treatment of vascular dementia and carried out experiments to verify the correlation between drug composition and disease. By screening the active components and key targets through various databases and drawing the topological network diagram, we obtained 502 effective compound targets, 601 disease targets, 95 disease-related compound targets, and 162 pathways. The pathway related to vascular dementia may be neurodegeneration-multiple diseases, PI3K-Akt signaling pathway, Mitogen-activated protein kinase signaling pathway, or HIF-1 signaling pathway. By detecting the learning and memory ability of vascular dementia rats, the morphology of the hippocampus under the electron microscope, the degree of neuronal damage, and autophagy-related proteins, the results showed that the Bushenhuoxue formula could improve the neuronal injury induced by ischemia in the hippocampus, down-regulate the level of autophagy, and thereby improve learning and memory. Therefore, the Bushenhuoxue formula may improve the ischemic injury of neurons by regulating the mechanism of neuronal autophagy.
Variable neuroprotective role of Filipendula ulmaria extract in rat hippocampus
Authors: Arsenijevic Natalija , Selakovic Dragica , Katanic Stankovic Jelena S. , Mihailovic Vladimir , Mitrovic Slobodanka , Milenkovic Jovana , Milanovic Pavle , Vasovic Miroslav , Nikezic Aleksandra , Milosevic-Djordjevic Olivera , Zivanovic Marko , Filipovic Nenad , Jakovljevic Vladimir , Jovicic Nemanja , Rosic Gvozden
Published: January 2022

We evaluated the influence of an antioxidant-rich extract of Filipendula ulmaria L. on anxiety levels induced by nano-sized particles of different calcium phosphates. Rats in experimental groups were administered with either nano-sized hydroxyapatite, tricalcium phosphate, or amorphous calcium phosphate in the presence of Filipendula ulmaria extract. Appropriate behavioral tests were performed to assess anxiety levels, while oxidative status and apoptosis parameters were determined in the hippocampus samples. The applied calcium phosphates increased oxidative stress markers in hippocampal tissue, accompanied by an enhanced pro-apoptotic mechanism. Moreover, the hippocampal immunoreactivity for brain-derived neurotrophic factor and GABAergic-A receptors was significantly lower following calcium phosphate nanoparticles intake. The observed functional and morphological alterations in the rat hippocampus occurred simultaneously with the anxiogenic response estimated in behavioral testing. The neuroprotective effect of Filipendula ulmaria was markedly manifested by the attenuation of oxidative damage induced by amorphous calcium phosphate and enhanced anti-apoptotic action in the rat hippocampus. The increased hippocampal immunoreactivity for brain-derived neurotrophic factor, GABAergic-A receptors and significant anxiolytic-like effects of Filipendula ulmaria may suggest a beneficial role of antioxidant supplementation in preventing anxiogenic response to nano-sized calcium phosphates.
Radiological outcomes for endovascular treatment of posterior communicating artery aneurysms: a retrospective multicenter study of the occlusion rate
Authors: Scerrati Alba , Trevisi Gianluca , Sturiale Carmelo Lucio , Salomi Francesco , De
						Bonis Pasquale , Saletti Andrea , Mangiola Annunziato , Tomatis Alberto , Di
						Egidio Vincenzo , Vigo Vera , Pedicelli Alessandro , Valente Iacopo , Rustemi Oriela , Beggio Giacomo , Iannucci Giuseppe , Milonia Luca , Ricciardi Luca , Cervo Amedeo , Pero Guglielmo , Piano Mariangela
Published: January 2022

Although several innovations in techniques and implantable devices were reported over the last decades, a consensus on the best endovascular treatment for intracranial aneurysms originating from the posterior communicating artery is still missing. This work investigates radiological outcomes of different endovascular techniques for posterior communicating artery aneurysms treatment in a retrospective multi-centric cohort. We included patients endovascularly treated for posterior communicating artery aneurysms from 2015 through 2020 in six tertiary referral hospitals. We evaluated the relationship between patients and aneurysms characteristics, baseline neurological status, radiological outcomes, and the different endovascular techniques. Overall, 250 patients were included in this study. Simple coiling was the most frequent treatment in 171 patients (68%), followed by flow-diverter stenting in 32 cases (13%). Complete occlusion was reported in 163 patients (65%), near-complete occlusion in 43 (17%), and incomplete occlusion in 44 (18%). Radiological follow-up was available for 247 (98%) patients. The occlusion rate was stable in 149 (60%), improved in 49 (19%), and worsened in 51 (21%). No significant difference in exclusion rate was seen between ruptured and unruptured aneurysms at the last follow-up (p = 0.4). Posterior communicating artery thrombosis was reported in 25 patients (9%), transient ischemic attack in 6 (2%), and in 38 patients (15%), subsequent procedures were needed due to incomplete occlusion or reperfusion. Endovascular strategies for posterior communicating artery aneurysms represent effective and relatively safe treatments. Simple coiling provides a higher immediate occlusion rate, although recanalization has been frequently reported, conversely, flow-diversion devices provide good long-term radiological outcomes.
Diagnostic performance of arterial spin-labeled perfusion imaging and diffusion-weighted imaging in full-term neonatal hypoxic-ischemic encephalopathy
Authors: Meng Linlin , Wang Qian , Li Yifang , Ma Xiangxing , Li Wen , Wang Qing
Published: January 2022

We evaluated the performance of arterial spin-labeled perfusion imaging and diffusion-weighted imaging in diagnosing full-term neonatal hypoxic-ischemic encephalopathy. Arterial spin-labeled, diffusion-weighted imaging and conventional magnetic resonance imaging (T1-weighted imaging, T2-weighted imaging and T2 fluid-attenuated inversion recovery) were performed in 23 full-term neonates with hypoxic-ischemic encephalopathy group 10 normal neonates (Control group). The cerebral blood flow and the apparent diffusion coefficient were measured in the bilateral basal ganglia, thalamus and frontal white matter. The effect of neonatal age on the CBF and apparent diffusion coefficient values were further investigated after dividing the 23 ischemic encephalopathy cases into three subgroups (1–3 days, 4–7 days, and 8–15 days). The cerebral blood flow values in the thalamus and lenticular nucleus were significantly higher. The apparent diffusion coefficient values in the thalamus, frontal white matter and lenticular nucleus head were significantly lower in the hypoxic-ischemic encephalopathy group than those in the Control group (p < 0.05). There were no significant differences between the ischemic encephalopathy and Control groups in the cerebral blood flow values in the caudate nucleus head and frontal lobe white matter (p > 0.05). The cerebral blood flow and apparent diffusion coefficient values in the thalamus and lenticular nucleus were negatively correlated. Comparison among different age subgroups of hypoxic-ischemic encephalopathyneonates showed that the cerebral blood flow value was higher. In comparison, the apparent diffusion coefficient value was lower in the 1–3 days old neonates than those in the older neonates (p < 0.05). Arterial spin-labeled and diffusion-weighted imaging could reflect the ischemic encephalopathy pathological processes more comprehensively. The cerebral blood flow measurement and apparent diffusion coefficient values in the thalamus and the lenticular nucleus may represent a novel way to diagnose ischemic encephalopathy early.
Altered cortical activity in patients with lower limb amputation based on EEG microstate
Authors: Shan Xinying , Wei Conghui , Liu Shaowen , Luo Jun
Published: January 2022

Previous studies have revealed significant changes in electroencephalogram (EEG) microstates in neuropsychiatric diseases, including schizophrenia, depression, and dementia. To explore the resting-state EEG microstate with amputation, we collected the EEG datasets from 15 patients with lower limb amputation and 20 healthy controls. Then, we analyzed the parameters of four classical EEG microstates (A–D) between the two groups. Specifically, the parameters were statistically analyzed, including duration, occurrence rate, time coverage, and transition rate. According to the results, the duration of microstate C (t = 2.95, p = 0.005) in the lower limb amputation group was significantly smaller compared with the control group, while the occurrence rate of microstate B (t = –2.22, p = 0.03) and D (t = –3.35, p = 0.002) were significantly larger in the lower limb amputation group. In addition, the transition rate of microstate differed significantly in AC, CA, DB between the two groups. Our results implied: (1) amputation has changed the resting-state EEG microstate; (2) EEG microstate analysis can be an approach to explore the alteration of cortical function.
Paeonol administration alleviates cognitive deficits and attenuates neural pathological changes in APP/PS1 mice
Authors: Meng Shengxi , Wang Bing , Li Wentao
Published: January 2022

Alzheimer’s disease typically presents with impaired cognition and pathological morphologic changes, including the accumulation of amyloid-β plaques. Disease-modifying drugs are in urgent need as neuroprotective therapies. Exploration of novel therapeutics for alleviating symptoms of Alzheimer’s disease has found promise in plant extracts of functional phenols. Paeonol is a water-soluble phenolic substance that has been shown to confer diverse biological effects, including neuroprotection. An Alzheimer’s disease model of APP/PS1 double transgenic mice was used in this study, and the therapeutic effects of paeonol were assessed after three weeks’ administration. It was found that paeonol treatment significantly increased behavioral performance in the Morris water maze test and increased discrimination rate in the novel object recognition test compared to vehicle-treated APP/PS1 mice. Histologically, paeonol treatment significantly alleviated the Aβ plaque burden, reduced neural loss, inhibited microglia activation, and decreased neuroinflammation in the brain of APP/PS1 mice. In addition, a number of Alzheimer’s disease-related synaptic plasticity deficits were ameliorated. The present results indicate that paeonol significantly relieved amyloid-β deposition and amyloid-β -mediated neuropathology in the brain of APP/PS1 mice, suggesting the potential of paeonol as a preventive and therapeutic agent for Alzheimer’s disease.
Prediction of the motor prognosis with diffusion tensor imaging in hemorrhagic stroke: a meta-analysis
Authors: Chang Min Cheol , Kwak Sang Gyu , Park Donghwi
Published: January 2022

This paper investigates whether diffusion tensor imaging performed within 2 weeks of intracerebral hemorrhage onset could predict the motor outcome by categorizing previous diffusion tensor imaging studies based on the time-point of performing diffusion tensor imaging (<2 weeks and ≥2 weeks after intracerebral hemorrhage onset). A comprehensive database search on PubMed, Embase, Cochrane Library, and SCOPUS was conducted. The pooled estimate was acquired using correlation analysis between the diffusion tensor imaging parameters of fractional anisotropy and motor recovery based on the period of stroke onset. In the results, out of 511 retrieved articles, eight were finally included in the meta-analysis. In patients who underwent diffusion tensor imaging within 2 weeks of intracerebral hemorrhage onset, a random-effects model revealed that the ratio of fractional anisotropy is a significant predictor of motor recovery of the hemi-side extremity after intracerebral hemorrhage (p = 0.0015). In patients who underwent diffusion tensor imaging after 2 weeks of intracerebral hemorrhage onset, a fixed-effects model revealed that the ratio of fractional anisotropy was also a significant predictor of motor recovery of the hemi-side extremity after intracerebral hemorrhage (p < 0.0001). Our meta-analysis revealed that ratio of fractional anisotropy (rFa) calculated from diffusion tensor imaging (DTI) performed ≥2 weeks of intracerebral hemorrhage onset had a positive correlation with the motor outcomes after intracerebral hemorrhage (ICH). Also, although diffusion tensor imaging was performed <2 weeks after intracerebral hemorrhage onset, the ratio of fractional anisotropy calculated from diffusion tensor imaging helped predict the motor outcome. Further analyses, including a more significant number of studies focused on this topic, are warranted.
MiR-325-3p functions as a suppressor miRNA and inhibits the proliferation and metastasis of glioma through targeting FOXM1
Authors: Xiong Qijiang , Su Hai
Published: January 2022

Glioma is a malignant brain tumor exhibiting high levels of proliferation and metastasis, and these have been related to its poor prognosis and high mortality rate. MicroRNA (miRNA)-325-3p exhibits tissue-specific expression profiles and is aberrantly expressed in multiple types of malignant tumors. Our research focuses on determining the function and mechanism of action of miR-325-3p in glioma. The relative expression levels of miR-325-3p in glioma tumor tissues and cell lines were verified by qRT-PCR. The effect of 325-3p on glioma tumor cell behavior was assessed using CCK-8 assays, EDU staining, colony formation assays, flow cytometry, transwell invasion assays, and a xenograft model. In addition, we searched for miR-325-3p targets, and their potential mechanism of action was demonstrated using a reporter assay and rescue experiments. Results showed that the expression levels of miR-325-3p in glioma cancer tissues and tumor cell lines were significantly lower than that of normal paired adjacent tissue or normal cell lines. Functional experiments illustrated that tumor proliferation, migration and invasion were suppressed via upregulation of miR-325-3p. To assess whether FOXM1 is a target of miR-325-3p, we examined this hypothesis using a luciferase report assay and then found that miR-325-3p could modulate the expression of FOXM1. Furthermore, the functional role of miR-325-3p was also confirmed in a xenograft model using nude mice. Together, our data demonstrated that in glioma, miR-325-3p may inhibit cancer cell growth through the suppression of FOXM1 and could be a promising new target for treating this type of brain cancer.
The Most Influential Factor to Pass Rate of Modified OSCE Exam on Student Batch 2 during Pandemic Period
Authors: Kusmiati Mia , Nilapsari Rika , Furqaani Annisa R , Dewi Miranti Kania
Published: January 2022

The Objective structure clinical examination is an assessment tool to evaluate clinical skills. There are many factors that influence to pass rate of modified OSCE. Moreover, during online learning implementation, there are some barriers. The aim of the study is to determine the most influential factor that contributing to achieving the learning outcome in terms of passing rate modified online OSCE. An observational study was chosen involving 87 medical students batch 2.  Sample size calculation used the formulation of an estimated proportion population with a simple random strategy. This study employed a questionnaire of online skill learning that was made by the researcher through analysis of factor exploratory. The participants were asked to score their agreement on the five-Likert scale. Using SPSS version 24 and software of AMOS 26, we analyzed the data for simple linear regression and structural equation modeling (SEM). Results were summarized following 2 factors that influencing pass rate of modified OSCE online, in terms of transactional distance (p value=0.001, r=0.235) and learning platform availability ((p value=0.013, r=0.087). Our finding highlights that self-reflection and student access to resources have significant contributions toward independent learner characteristics. This study has contributed to solving the problem regarding the foundational concept for the requirement of online learning. The theoretical concept of a learning platform also enhances online teaching. Foremost and utmost that self-reflection and student access to resources have become two important factors to autonomy learning. The major strength of this study is the systematic manner in which it was conducted.
Relationship of Access to Clean Water with Prevalence of Stunting in Puskesmas Cicalengka in 2020
Authors: Daiva Aldo Dimitri , Nurhayati Eka , Fadillah Yanti
Published: January 2022

Bandung Regency was ranked the 4th highest in terms of the prevalence of stunting in West Java Province. District of Cicalengka was ranked as the 6th highest in terms of the prevalence of stunting in Bandung Regency as much as 33,7%. These numbers did not reach the World Health Organization (WHO) target, which is to reduce stunting numbers to less than 20%. It also did not reach the Bandung Regency Strategic Plan 2016-2021 target to reduce stunting prevalence to less than 14 %. Stunting was considered to be related to access to clean water. The aim of this study was to measure the relationship between access to clear water and the prevalence of stunting in Puskesmas Cicalengka in 2020. This study was analytic research using a cross-sectional design.  Data that was used in this research was data of height per age in children under five years and data of access to clean water. Data were extracted from the annual report of Puskesmas Cicalengka 2020. The number of the subject which appropriate with the inclusion criteria was 5.179. The sampling technique used in this study was the whole sampling. Data were analyzed using univariate analysis to describe the characteristic of subjects and chi-square test to measure the relationship between the two variables using software statistical product and service solution (SPSS) for windows version 18.0. Chi-square test reveals that the p-value is lower than 0,05 (p=0.000). It can be concluded that access to clean water is related to the prevalence of stunting. Improved collaboration between environmental health programs and maternal and child health programs in Puskesmas Cicalengka is needed to find the solution.
PENERAPAN KAIDAH KHURUJ MIN AL - KHILAAFI MUSTAHAB DALAM FIKIH
Authors: Ali Zainab
Published: January 2022

is article will try to describe the application of the application of al-khuruju min khilaafi mustahabbu. Where are the rules that talk about getting out of something that is very liked. This is quite important, especially in ethical issues in khilafiyah that occur in fiqh chapters and in the context of exercising caution in religion. Precautionary measures for cases that still fall under jurisprudence are ordered. It is even said that including cases of shubhat are cases where there is a difference in fiqh. Of course the rule "Al-Khurūj Min al-Khilāf Mustahab" cannot be applied absolutely without conditions. However, in practice the scholars define several terms, so that not all differences are mu'tabar and are driven to get out of those differences. this paper is only how to discuss Sayyid Bakri using the fiqh rules "Al-Khurūj Min al-Khilāf Mustahab".
Protecting Public Health and Preserving the Financial Viability of North Carolina’s Critical Health Care Facilities during Infectious Disease Outbreaks
Authors: Zeff Harrison , DeFelice Nicholas , Characklis Gregory W. , Su Yufei , Percha Bethany
Published: January 2022

While hospitals’ primary emphasis during the COVID-19 pandemic has been on ensuring sufficient health-related resource capacity (e.g., ICU beds, ventilators) to serve admitted patients, the impacts of the pandemic on the financial viability of hospitals has also become a critical concern. Data from the period March 2020-Janaury 2021 suggest that the halt to elective and non-emergency inpatient procedures, combined with a reduction in emergency room procedures, led to losses equal to 6.5% of revenue from inpatient procedures, or about $825 million. This study finds that societal measures to reduce the community transmission rates have a larger impact on available healthcare capacity and hospital financial losses than hospital-level decisions. This study illustrates the tradeoffs between hospital capacity, quality of care, and financial risk faced by health care facilities throughout the U.S. as a result of COVID-19, providing potential insights for many hospitals seeking to navigate these uncertain scenarios through adaptive decision-making.
First observational record of Siberian weasel Mustela sibirica Pallas, 1773 in Dhorpatan Hunting Reserve, Nepal
Authors: Basnet Hari , Lama Deepa , Thakur Manju Shree , Rajbhandari Prakriti , Bista Rejina , Vaidya Rona , Aryal Prakash Chandra
Published: January 2022

Siberian weasel Mustela sibirica Pallas, 1773 is one of the least known small carnivores in Nepal. Only a few authenticated localities of Siberian weasel are known to exist in Nepal. In March 2021, a week-long field trip to the Dhorpatan Valley documented the first confirmed record of Siberian weasel in Dhorpatan Hunting Reserve in Western Nepal.
New locality record of the Lofty bath white butterfly Pontia callidice (Hübner, 1800) in Nepal
Authors: Suwal Sanej Prasad , Hengaju Krishna Dev , Kusi Naresh
Published: January 2022

Lofty bath white Pontia callidice is a little-known butterfly of Nepal, reported only from Darchula district, Far Western Nepal. We recorded the new distribution eastward of this species 166 km N-E far from its previous range in Talung and Gyaukhola Valley of Upper Humla in July 2017 at elevations between 4400 to 4829 m above sea level. This is also the highest elevation record of this species.
Defining Ship Principal Dimensions Using Comparison Method
Authors: Harsi Renanda Bayu , Arif Nuzulul
Published: January 2022

Abstract

In the process of finding the principal dimension of the ship there are various methods that can be used. In this study, the Comparison method will be used to obtain the main size of the ship and the main dimensions of the ship are obtained, namely, length (L) = 20,152 meters, beam (B) = 5.5 meters, depth (H) = 2,939 meters, draft (T) = 1.5129 meters, service speed (Vs) = 20 knots. The ship's resistance is 152.6 kN at service speed (Vs) = 20 knots. And can be overcome with a power of 2426.31 HP. The power taken to meet these needs is 2500 HP supplied by 2 outboard engines with a power of 1300 HP each.

Keywords : Comparison Method.
Prioritas Strategi Pemasaran Biji Kopi Panggang Menggunakan Metode Analytical Hierarchy Process (AHP) Pada Lestari Coffee Roasters
Authors: Anjani Mega , Puspitaningrum Dwi Aulia , Senjawati Nanik Dara
Published: January 2022

Penelitian ini bertujuan untuk menganalisis prioritas alternatif strategi yang tepat dalam upaya pengembangan pangsa pasar pada Lestari Coffee Roasters berdasarkan bauran pemasaran di Lestari Coffee Roasters. Penelitian ini menggunakan metode deskriptif. Metode pelaksanaan penelitian ini menggunakan studi kasus dan metode penentuan responden menggunakan metode purposive. Macam data yang digunakan yaitu data primer dan data sekunder. Teknik pengumpulan data yaitu melalui observasi, wawancara, dokumentasi dan pencatatan, serta kuesioner. Teknik analisis yang digunakan adalah EFE (External Factor Evaluation), IFE (Internal Factor Evaluation), Matriks IE (Internal-External), dan AHP (Analitycal Hierarchy Process). Hasil Penelitian menunjukkan bahwa faktor bauran pemasaran yang menjadi prioritas utama dalam penyusunan strategi pemasaran biji kopi panggang pada Lestari Coffee Roasters berturt-turut adalah orang, tempat, promosi, proses, sarana fisik, harga, dan produk. Alternatif strategi pemasaran yang menjadi prioritas bagi Lestari Coffee Roasters yaitu pengembangan produk, Integrasi, pengembangan pasar, dan penetrasi pasar. Kata kunci : strategi pemasaran, bauran pemasaran, AHP, prioritasProgram Studi Agribisnis Jurusan Agribisnis Fakultas Pertanian Universitas Pembangunan Nasional “Veteran” Yogyakarta
Strategi Pemasaran Pada Rumah Produksi Kelorida Di Kabupaten Bantul Yogyakarta
Authors: Sijabat Ondho Shinta Ulina , Budiarto Budiarto , Utami Heni Handri
Published: January 2022

Penelitian ini bertujuan untuk (1) Mengidentifikasi dan menganalisis bauran pemasaran yang telah diterapkan (2) Menganalisis faktor eksternal dan internal (3) Menganalisis alternatif strategi dengan metode AHP (Analytical Hierarchy Process). Penelitian ini menggunakan metode deskriptif sedangkan metode pelaksanaannya menggunakan studi kasus. Macam data yang digunakan berupa data primer dan data sekunder. Teknik pengumpulan data yaitu observasi, wawancara, kuesioner dan pencatatan. Teknik analisis yang digunakan adalah analisis IE (Internal Eksternal) dan AHP (Analytic Hierarchy Process) untuk  memilih pengambilan keputusan strategi yang sesuai diterapkan pada Rumah Produksi Kelorida. Hasil penelitian menunjukkan bahwa (1) berdasarkan analisis melalui bauran pemasaran 4P Rumah Produksi Kelorida telah menjalankan kegiatan pemasaran dengan keseluruhan parameter yang dijalankan diantaranya produk (variasi, kualitas, kemasan), harga (diskon, efisiensi harga dan variasi harga), promosi (pameran, media sosial, dan hubungan masyarakat), tempat (pendistribusian, aksesibilitas dan informasi lokasi). (2) Berdasarkan hasil analisis menggunakan Matriks IE (Internal- External) terhadap faktor internal dan eksternal Rumah Produksi Kelorida, maka diperoleh posisi usaha Rumah Produksi Kelorida yaitu posisi tumbuh dan membangun. (3) Berdasarkan hasil dari AHP (Analytic Hierarchy Process), prioritas utama strategi pemasaran yang diterapkan Rumah Produksi Kelorida adalah strategi pengembangan produk.Kata Kunci: AHP, eksternal, internal, strategi pemasaran, bauran
Program Kampung Empon-Empon Di Dusun Ngalian Desa Widodomartani Kecamatan Ngemplak Kabupaten Sleman
Authors: Hasanah Nurul , Kismantoroadji Teguh , Hamidah Siti
Published: January 2022

Penelitian ini bertujuan untuk (1) mengkaji dimensi partisipasi masyarakat (2) mengkaji unsur partisipasi masyarakat (3) mengkaji bentuk partisipasi masyarakat dalam Program Kampung Empon-Empon di Dusun Ngalian Desa Widodomartani Kecamatan Ngemplak kabupaten Sleman. Penelitian ini menggunakan pendekatan kualitatif. Teknik penentuan informan yaitu purposive sampling. Informan dalam penelitian ini adalah Ketua, Wakil Ketua, Bendahara, Penasehat, Seksi Humas Saran dan SDA serta pengurus demplot RT 04 Kampung Empon-Empon. Sumber Data yang digunakan adalah data primer dan data sekunder. Teknik pengumpulan data yaitu menggunakan observasi, wawancara, dan dokumentasi dengan pengujian keabsahan data menggunakan triangulasi sumber. Teknik analisis data yaitu dengan mengumpulkan data, mereduksi data, penyajian data dan penarikan kesimpulan dan verifikasi. Hasil dari penelitian ini (1) Dimensi Partisipasi pada Program Kampung Empon-Empon meliputi pembuatan keputusan, pelaksanaan, pemanfaatan hasil, serta monitoring dan evaluasi (2) Unsur partisipasi pada Program Kampung Empon-Empon yaitu telah berada di tahap tanggung jawab. Masyarakat merasa memiliki Program Kampung Empon-Empon sehingga masyarakat merasa punya tanggung jawab untuk membantu melancarkan program (3) Bentuk partisipasi masyarakat pada Program Kampung Empon-Empon yaitu memberikan ide dan pengetahuan, gotong royong, membantu dalam sarana prasarana, dan mengikuti pertemuan. Kata kunci: partisipasi masyarakat, dimensi partisipasi, unsur partisipasi, program kampung empon-empon, bentuk partisipasi
Kelayakan dan Strategi Pengembangan Usaha Keju Natural Di Rumah Keju Jogja Daerah Istimewa Yogyakarta
Authors: Dewi Richa Puspita , Budiarto Budiarto , Suprihanti Antik
Published: January 2022

Penelitian ini bertujuan untuk 1) menganalisis Keragaan usaha keju natural, 2) menganalisis kelayakan Usaha keju natural, 3) menetapkan prioritas strategi pengembangan usaha yang dapat diterapkan untuk mengembangkan Usaha keju natural. Metode dasar penelitian yang digunakan adalah metode deskriptif. Metode pelaksanaan dalam penelitian ini menggunakan metode studi kasus. Metode penentuan responden penelitian menggunakan metode purposive. Jenis data yang digunakan yaitu data primer dan sekunder. Metode pengumpulan data yaitu dengan wawancara, observasi, dan studi pustaka. Teknik analisis data yang digunakan dalam penelitian ini yaitu untuk keragaan dianalisis secara deskripsi, kelayakan usaha dianalisis menggunakan analisis benefit cost ratio dan strategi pengembangan usaha dianalisis menggunakan metode IFE, EFE, SWOT, IE dan Metode Analytical Hierarcy Process (AHP). Berdasarkan penelitian yang telah dilakukan didapatkan hasil penelitian 1). Usaha keju natural di Rumah Keju Jogja memiliki lokasi produksi yang strategis, pemasaran yang dilakukan secara online dan offline, memiliki sertifikat halal dari MUI dan sudah melakukan fungsi – fungsi manajemen dalam usahanya. 2). Usaha keju natural di “Rumah Keju” Jogja selama tidak layak dilaksanakan dengan nilai b/c ratio sebesar 0,38 3) strategi pengembangan usaha yang menjadi prioritas untuk pengembangan usaha keju natural di Rumah Keju Jogja adalah penetrasi pasar melalui meningkatkan promosi melalui penggunaan facebook dan instagram yang lebih optimal atau melalui media promosi lainnnya untuk meningkatkan penjualan.Kata kunci : strategi pengembangan, kelayakan usaha, keju natural, keragaan
„Stracone pokolenie” i kryzys tożsamości ukraińskich dipisów w powieści Enej ta žyttia inšyh Jurija Kosača
Authors: Stefanowska Lidia
Published: January 2022

Yurii Kosach Poet, writer, and dramatist; nephew of Lesia Ukrainka; grandson of Olena Pchilka. After graduating from the Academic Gymnasium of Lviv, Kosach studied law at Warsaw University. He began publishing short stories in student newspapers in 1927. Between 1928 and 1929 he published most of his works in the nationalist journal Literaturno-naukovyi vistnyk edited by Dmytro Dontsov after he had broken off his relations with Dontsov in 1929. After the war he lived in displaced persons camps in Germany and was an active member of the writers’ organization MUR. In 1949 he immigrated to the United States. By far the largest and most interesting body of work is Kosach’s prose, written prior to his emigration to the United States and then in the last decade of his life, first of all Enei ta zhyttia inshykh (Aeneas and the Lives of Others, 1947) where he argued the issues of new Ukrainian culture with so called “lost generation”.