bluuebunny/crossref_metadata_2025 huggingface dataset:
A racionalidade subjacente à práxis do professor no contexto da educação superior
Authors: Carneiro Isabel Magda Said Pierre , Freire Ludmila de Almeida , Cavalcante Maria Marina Dias
Published: August 2020

Este estudo pretende desenvolver uma análise sobre alguns princípios fundantes da racionalidade subjacente a práxis do professor bacharel no ensino superior. Inserida numa abordagem qualitativa de educação, a pesquisa se classifica como estudo de caso tendo como lócus o Instituto Federal de Educação, Ciência e Tecnologia (IFCE), campus Maracanaú, CE. Como estratégia de coleta de dados, realizou-se entrevista semi-estruturada com três professores. Os dados revelam as dificuldades enfrentadas pelos entrevistados no início de suas carreiras e apontam a necessidade de formação pedagógica para uma melhoria de seu trabalho. Destaca-se a importância dos estudos sobre a formação para a docência universitária, pela valorização e ressignificação do saber prático do professor constantemente reconstruído em processos intersubjetivos, reconhecendo na práxis a dialeticidade da relação teoria e prática.Palavras-chave: Trabalho docente. Saberes profissionais. Racionalidade pedagógica.
O profissional de apoio na rede regular de ensino: a precarização do trabalho com os alunos da Educação Especial
Authors: Martins Silvia Maria
Published: August 2020

Este artigo apresenta o resultado da pesquisa de Mestrado desenvolvida durante o ano de 2010 e 2011 sobre o trabalho do profissional de apoio em turmas de Educação Infantil e Ensino Fundamental que possuem sujeitos da Educação Especial matriculados nos municípios de Florianópolis e São José. Investigou-se como a atuação destes profissionais tem sido organizada para o atendimento aos sujeitos da Educação Especial nas classes comuns. A partir desta pesquisa, foram evidenciadas as problemáticas existentes neste cargo que agregadas, constituem elementos de um processo de precarização e intensificação do trabalho docente e demonstram, de forma explícita, o modelo de inclusão escolar que está sendo difundido nas políticas nacionais para Educação Especial.Palavras-chave: Profissional de apoio. Trabalho docente. Educação especial.
Editorial
Authors: PPGE/UCDB Professores do
Published: August 2020

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Projeto Convulsivo Sinódico − exercício de experiência estética e de responsabilidade com o outro
Authors: Ijano Batista Sônia Aparecida , Boschetti Vânia Regina
Published: August 2020

A escola pública vive tempos difíceis, num contexto que visa a desqualificá-la, dando preferência aos investimentos privados na educação. Atualmente, é vista como inferior e incompetente perante os desafios da contemporaneidade. Na dimensão do conceito de ensaio de Larrosa, busca-se contribuir com a temática, analisando o Projeto Convulsivo Sinódico da E. E. “Prof. Carlos Augusto de Camargo”, de Piedade, SP, criado e desenvolvido pela escola no período de 1993-2017, à maneira de Walter Benjamin, para quem o passado pode ser retomado e se revelar em novas formas no presente, e de Roger Chartier, na dimensão da história cultural, de como uma realidade é dada a ler. A metodologia utilizada é a pesquisa qualitativa junto aos Planos Diretores e de Gestão da Escola. Os resultados sinalizam caminhos a serem explorados na dimensão de Gabriel Perissé, em torno da alfabetização estética, uma forma de romper com as cristalizações nos modos de ver e viver a educação; e de Emmanuel Lévinas, acerca da responsabilidade com o outro.
Aspectos históricos e políticos do Processo de Bolonha: expansão de políticas de internacionalização na Educação Superior
Authors: Mondardo Brandalise Giselly Cristini , Heinzle Márcia Regina Selpa
Published: August 2020

Este artigo tem como objetivo compreender os aspectos históricos e políticos do Processo de Bolonha por meio de um estado do conhecimento realizado no Portal de Periódicos da CAPES, entre os anos de 2006-2018, considerado um montante refinado de 23 artigos. Trata-se de uma pesquisa qualitativa e hermenêutica, no sentido de compreender o referido movimento que contribuiu para a expansão de políticas de internacionalização na Educação Superior. A partir do levantamento de dados, foi possível considerar algumas categorias de análise que contribuíram para fundamentar as presentes discussões. Os resultados indicam que se trata de uma conjuntura definida por meio de um panorama que instala e orienta sistemas educativos a partir da visão eurocêntrica e de globalização econômica, influenciando políticas mundiais de Ensino Superior, formação docente, entre outras. Faz-se necessário refletir sobre o contexto e as políticas advindas do Processo de Bolonha, bem como as consequências que dele decorrem para que sejam possíveis desenvolver estratégias e ações que possibilitem atuações colaborativas e contribuintes para todos na sociedade.
Currículo, identidade e relações étnico-raciais: a escola mediando as fronteiras da in/exclusão.
Authors: De Ávila Cristiane Bartz , Hypolito Álvaro Moreira
Published: August 2020

O presente trabalho tem como foco analisar fatores que podem influenciar o currículo escolar para uma educação crítica, no sentido de mediar as fronteiras da in/exclusão em relação às questões étnico-raciais. Delineia um breve histórico sobre as relações desiguais que permearam o período colonial e pós-colonial no Brasil, com evidência para a luta dos africanos e afro-brasileiros, no sentido de busca de uma condição de escolarização, a fim de uma inserção social. São chamados alguns autores que contribuíram na sociologia da educação para os debates em torno da categoria currículo. A intenção foi partir de breves descrições de seus pensamentos, destacar as teorias críticas e pós-críticas e sua relação com respeito ao papel da escola na sociedade. A partir daí, o artigo debate o porquê de algumas legislações serem cumpridas ou não. Quais interesses e relações de poder permeiam o currículo escolar? Por que uma lei inclusiva como a 11.645/2008 não consegue estar presente de forma efetiva no currículo escolar? Questões sobre performatividade e gerencialismo nos ajudam a pensar sobre a problemática levantada. Por fim, o texto encaminha como alternativa a ideia de microrresistências ao poder instituído, em que uma pedagogia culturalmente relevante pode ser uma das formas para que a escola medeie as fronteiras entre a in/exclusão.
Discipline of Teaching English as an International Language – D-TEIL: perspectives for language teacher education
Authors: Moura Gustavo , Morgan Brian
Published: August 2020

The role international practicum placements have in the professional development of language educators is a contentious issue, with not all researchers in agreement that international practica are necessarily natural, neutral, or beneficial, to borrow from Pennycook’s (2007, 2012, 2017) stance on English language teaching internationally. Scholars like Santoro (2007, 2009), for instance, have expressed concern that international practica constitute a little more than a form of educational tourism that is potentially exploitative of the host communities. However, some program developers and researchers acknowledge and prioritize the value-laden and sociopolitical nature of practice teaching abroad and strive to facilitate ethical and critical practices (MORGAN; MARTIN, 2014; MARTIN; MORGAN, 2015, 2019). For that reason, this paper critically analyzes crossing borders with reference to the D-TEIL certificate program. The outcomes of an international practicum experience suggest changes towards considering the multiplicity of knowledge and aim at developing strategies for language teacher education programs towards ethical practices.
Chasing the Phantom Ship: Revisiting Interpretations of the Boca Chica No. 2 Shipwreck on the Texas Coast
Authors: Borgens Amy , Hoyt Steven
Published: August 2020

Boca Chica Beach spans the south Texas coast in Cameron County for a distance of roughly 12 kilometers between Brazos Santiago Pass and the mouth of the Rio Grande River at the Texas and Mexican border. More than 165 historic ships have been reported lost along the south Texas coast in this general area and at least four, or portions thereof, have been discovered so far. The most well-known of the shipwreck remains is archeological site 41CF184, nicknamed Boca Chica No. 2, which has gained almost mythological status in the region as it has long been circumstantially linked to the Mexican warship Moctezuma; not-so-coincidentally one of the most famous shipwrecks in the region. Is Boca Chica No. 2 the famous warship, once believed to be a “phantom” because it so often eluded the Texian patrols? Evidence suggests otherwise but the significance of both the historic ship and the archeological site invite reexamination of this unresolved mystery.
Comparative Evaluation of Bismuth-Silver and Bismuth-Tin Alloys for Plug and Abandonment
Authors: Zhang Hua , Ramakrishnan T. S. , Elkady Youssef Magdy , Feng Yixuan , Elias Quincy Kurleigh
Published: August 2020

As an alternative to cement, the feasibility of bismuth-tin (BiSn; contains 58 wt% Bi and 42 wt% Sn, abbreviations are not in stoichiometric ratio) as a low melting-point plug has been tested by Zhang et al. (2020) for rigless plug-and-abandonment (P&A) service of offshore wells. Similar to BiSn, bismuth-silver (BiAg; contains 97.5 wt% Bi and 2.5 wt% Ag, abbreviations are not in stoichiometric ratio) also exhibits desirable properties compared with Portland cement. However, because of its greater melting point, BiAg has potentially a wider application than BiSn, especially in deep formations. In the present study, we investigate the feasibility of BiAg alloy for P&A. The bond quality of the alloy-shale cores is evaluated through shear, tensile, push-out, and permeability tests, and compared with those of BiSn alloy-shale and cement-shale cores. To avoid phase change-induced shale damage at elevated temperature while setting BiAg plugs, water was first extracted with supercritical carbon dioxide (CO2). For shear and tensile tests with pinhole-anchored BiAg, the ultimate strength and modulus were measured as a function of anchor points at different temperatures (21, 80, and 110°C). For the push-out tests, shale samples of smooth, rough, and pinholed surfaces were prepared with the BiAg alloy plug. In general, we find that, without anchors, bond failure precedes shale failure. Results for cement-shale cores are also reported for comparison. We contrast the performance of BiAg and BiSn alloys at 21, 65, 80, and 110°C to determine the crossover temperature for deployment suitability.
Effect of Surface Force on Nanoconfined Shale-Gas Flow in Slit Channels
Authors: Gao Yanling , Wu Keliu , Chen Zhangxin , Li Jing , Li Qian , Dong Xiaohu , Tian Weibing , Liu Yishan , Zhu Qingyuan , Bi Jianfei
Published: August 2020

A model for gas transport in nanoscale channels in shale-gas reservoirs (SGRs) is proposed using a new effective mean free path (MFP) model, which considers the effects of surface/gas interaction and the geometrical termination of a nanochannel boundary. In addition, the influences of the nanochannel dimension, formation-burial depth, surface type, and gas type on nanoconfined gas flow in slit channels are addressed. The nanoconfined gas-flow behavior is investigated for a wide range of temperature and pressure in this work because of the large prospects of shale gas in deep and ultradeep formations with pressure up to 100 MPa and temperature up to 480 K. The newly developed effective MFP model and the gas-flow-rate model are successfully validated with data from molecular dynamics (MD) simulations and experiments. Results show that the effect of surface force reduces the MFP and gas-flow capacity, which increases with a decreasing pressure, a decreasing channel size, and an increasing temperature; that the nanoconfinement effect has weaker influence on gas-transport capacity as the formation-burial depth increases and greater influence as formation pressure decreases during hydrocarbon production from SGRs; that a surface type affects the gas transport, and the gas-flow capacity in carbon (C) channels (organic channels) is stronger than that in silicon (Si) channels (inorganic channels) with the same size; and that the differences among the transport capacities of nitrogen (N2), argon (Ar), and methane (CH4) are not obvious, while the transport capacities of helium (He) are greatly lower compared with CH4 at both the SGR temperature and the laboratory temperature.
The association between pelvic asymmetry and non-specific chronic low back pain as assessed by the Global Postural System. 
Authors: Yu Qiuhua , Huang Huanjie , Zhang Zhou , Hu Xiaoqian , Li Wenfeng , Li Le , Chen Min , Liang Zhenwen , Lo Wai Leung Ambrose , Wang Chuhuai
Published: August 2020

Background: Empirical evidence that demonstrates the relationship between pelvic asymmetry and non-specific chronic low back pain (NCLBP) is currently lacking. Objective: To establish the reliability of the Global Postural System (GPS) in assessing pelvic asymmetry and identify the association between pelvic asymmetry parameters and the occurrence of NCLBP in young adults.Design: A cross-sectional, regression study. Methods: People who were aged between 18 and 30 and were diagnosed with NCLBP were recruited. Healthy individuals who were matched for age, sex, and education level were recruited as controls. Global Postural System (GPS) was employed to assess pelvic asymmetry. Prior to exploring the association, the reliability of GPS was assessed by the ICC (2, k) for interrater reliability, ICC (3, k) for intra-rater reliability, standard error and minimal detectable difference. Bivariate correlation analysis and logistic regression analysis were used to determine the relationship between pelvic asymmetry and the occurrence of NCLBP.Results: Twenty-eight healthy participants and 28 people with NCLBP were recruited. Moderate to excellent ICCs were observed for the inter-rater and intra-rater reliability of most postural parameters. The bivariate correlation analysis indicated that age, body mass index and pelvic asymmetry parameters were related to the occurrence of NCLBP. Pelvic angle asymmetry (odds ratio=1.17), and asymmetry of the distance between the posterior superior iliac spine and the floor (odds ratio=1.21) were associated with NCLBP.Limitation: This study did not explore the causal relationship between pelvic asymmetry in the sagittal plane/pelvic asymmetry in the transverse plane and the occurrence of NCLBP. The interpretation of the results may not be generalized beyond the sample population.Conclusions: The GPS is a reliable method to assess pelvic asymmetry in a clinical setting. Two pelvic parameters were associated with the presence of NLBP. Measurement of pelvic asymmetry may assist in the early identification of potential occurrence of NCLBP but further work is required.
Reframing the magnetotelluric phase tensor for monitoring applications: improved accuracy and precision in strike determinations
Authors: Bravo-Osuna Ana Gabriela , Gómez-Treviño Enrique , Cortés-Arroyo Olaf Josafat , Delgadillo-Jáuregui Néstor Fernando , Arellano-Castro Rocío Fabiola
Published: August 2020

The magnetotelluric method is increasingly being used to monitor electrical resistivity changes in the subsurface. One of the preferred parameters derived from the surface impedance is the strike direction, which is very sensitive to changes in the direction of the subsurface electrical current flow. The preferred method for estimating the strike changes is that provided by the phase tensor because it is immune to galvanic distortions. However, it is also a fact that the associated analytic formula is unstable for noisy data, something that limits its applicability for monitoring purposes, because in general this involves comparison of two or more very similar data sets. On the other hand, the classical Swift’s approach for strike is very stable for noisy data but it is severely affected by galvanic distortions. In this paper we impose the criterion of Swift’s approach to the phase tensor. Rather than developing an analytical formula we optimize numerically the same criterion. This stabilizes the estimation of strike by relaxing an exact condition to an optimal condition in the presence of noise. This has the added benefit that it can be applied to windows of several periods, thus providing tradeoffs between variance and resolution. The performance of the proposed approach is illustrated by its application to synthetic data and to real data from a monitoring array in the Cerro Prieto geothermal field, México.
The low fresh gas flow anesthesia and hypothermia in neonates undergoing digestive surgeries: A retrospective before-after study
Authors: Cui Yu , Wang Yu , Cao Rong , Li Gen , Deng Lingmei , Li Jia
Published: August 2020

Background: Based on the previous investigation in our institution, the incidence of intraoperative hypothermia in neonates was high. Since September 1st, 2019, the recommendation had been launched to utilize ≤1 L/min fresh gas flow during the neonates’ surgical procedure. We therefore intended to evaluate the association between low fresh gas flow anesthesia and the occurrence of hypothermia in neonates undergoing digestive surgeries. Methods: A retrospective chart review, before-after study was conducted for neonates who underwent digestive surgeries. The primary outcomes were the incidence of hypothermia. The secondary outcomes included hospital mortality, the value of lowest temperature, blood loss, mean body temperature during the surgery, the length of hypothermia during the surgery and postoperative hospital length-of- stay (PLOS). Results: 249 neonates fulfilled the eligibility criteria. The overall incidence of intraoperative hypothermia was 81.9%. The low fresh gas flow anesthesia significantly reduced the odds of hypothermia [routine group: 149 (87.6%) versus low flow group: 55 (69.6%); p ＜ 0.01]. Moreover, the low fresh gas flow anesthesia could reduce the length of hypothermia [routine group: 104 mins (50, 156) versus low flow group: 30 mins (0,100); p ＜ 0.01], as well as elevate the value of lowest temperature for neonates [routine group: 35.1℃ (34.5, 35.7) versus low flow group: 35.7℃ (35.3, 36); p ＜ 0.01]. After adjustment for confounding, low fresh gas flow anesthesia and the length of surgical time were independently associated with intraoperative hypothermia.Conclusions: Low fresh gas flow anesthesia is an effective way to alleviate hypothermia in neonates undergoing open digestive surgery.
RBE-weighted dose conversions for patients with recurrent nasopharyngeal carcinoma receiving carbon-ion radiotherapy from the local effect model to the microdosimetric kinetic model
Authors: Zhang Liwen , Wang Weiwei , Hu Jiyi , Lu Jiade , Kong Lin
Published: August 2020

Background

We sought to establish a conversion curve to convert the RBE-weighted doses calculated by local effect model I (LEM) (LEM RBE-weighted doses) in patients with locally recurrent nasopharyngeal carcinoma (rNPC) to the RBE-weighted doses calculated by microdosimetric kinetic model (MKM) (MKM RBE-weighted doses). We also converted the LEM dose constraints (RBE-weighted dose constraints in LEM plans) for the brain stem, spinal cord, and optic nerve based on this curve.

Methods

Data from 20 patients with rNPC receiving carbon-ion radiotherapy (CIRT) in our hospital were collected. LEM in Raystation (V8A, Raystation, Sweden) was used to generate treatment plans. The clinical target volume CTV1（GTV+5mm）was given 3 Gy (RBE) per fraction. Ninety-nine percent of target volumes should be covered by 95% of the prescriptions; the maximum doses of the brainstem and spinal cord were < 45 Gy (RBE) and < 30 Gy (RBE), respectively. The doses covering 20% volumes of optical nerves/chiasms D20 were < 30 Gy (RBE). Then physical doses of the LEM plans were recalculated by using MKM in Raystation to generate MKM plans. A series of conversion factors (i.e., the ratio of LEM RBE-weighted dose to MKM RBE-weighted dose) was then obtained by using an isovolumetric dose method. The LEM plan prescriptions (LEM prescription) and dose constraints of the organs at risk (OARs) (OAR constraints) were converted to the corresponding MKM prescriptions and dose constraints using this conversion curve.

Results

For the CTV1 fractional RBE-weighted dose prescription of 3.00 Gy (RBE) and CTV2 of 2.70 Gy (RBE) in LEM plans, the conversion factors (LEM RBE-weighted dose/MKM RBE-weighted dose) were 1.37 (CI 95％ 1.35–1.39) and 1.46 (1.41–1.51), respectively. The average conversion factors from 1.37(CI 95％ 1.33–1.41) to 3.09 (2.94–3.24) corresponded to the LEM fractionated doses from 2.86 Gy (RBE) to 0.24 Gy (RBE), including the doses constraining upon OARs. LEM RBE-weighted doses of 30 Gy (RBE) and 45 Gy (RBE) in 21 fractions were converted to MKM RBE-weighted doses of 16.64 Gy (RBE) and 30.72 Gy (RBE) in 16 fractions.

Conclusions

This conversion curve could be used to convert LEM RBE-weighted doses to MKM RBE-weighted doses for patients with rNPC receiving CIRT, providing dose references for re-irradiation therapy.
Double plating with autogenous bone grafting as a salvage procedure for recalcitrant humeral shaft nonunion
Authors: Feng Dongxu , Wang Xiaolong , Sun Liang , Cai Xiao , Zhang Kun , Wang Zhan , Zhu Yangjun
Published: August 2020

Background: Despite the majority of humeral shaft nonunions respond well to surgical intervention, a surgeon still encounters a patient with humeral shaft nonunion who had already undergone repeated surgeries for nonunion. This study is a retrospective analysis of the efficacy of the treatment of recalcitrant humeral shaft nonunions using double locking compression plate (LCP) fixation in combination with autogenous iliac crest bone grafting.Methods: A consecutive series of aseptic recalcitrant humeral shaft nonunion underwent surgical treatment between May 2010 and August 2017 in the authors’ institute. Standardized treatment included a thorough debridement, double LCP and screw fixation, and autogenous iliac bone graft. The injury type, the bone affected by nonunion, and the duration of nonunion were recorded for all patients. The main outcome measurements were Constant and Murley scale for shoulder function, Mayo elbow performance index (MEPI) for elbow function, and the visual analog scale (VAS) for pain. In addition, all complications were documented.Results: The study consisted of six females and nine males with a mean age of 45.3±13.1 years. Each patient had already undergone at least once failed surgical management for nonunion. The average duration that the bone remained ununited before the index intervention was 126.8±124.2 months. All patients achieved bone union without implant failure. At the final follow-up, both the mean Constant and Murley joint function score and the mean MEPI were significantly improved, and the mean VAS score significantly decreased. Each patient was highly satisfied with the treatment. Complications were only seen in four patents, including one super wound infection, one radial nerve palsy, one ulnar never palsy, and one discomfort at the iliac crest.Conclusion: Double plate fixation combined with autogenous iliac crest bone grafting can result in successful salvage of humerus nonunions in patients who have failed prior surgical interventions.
Effect of Acupotomy in Knee Osteoarthritis Patients: Study Protocol for A Randomized Controlled Trial
Authors: Xu Danghan , Lee Minghui , Huang Cihui , Wei Jia , Zhou Mengxue , Yao Taotao , Lu Jingjing , Zhao Wenjing , Xu Nuo , Huang Ruina , He Jun , Zheng Liang
Published: August 2020

BackgroundSymptomatic knee osteoarthritis patients are common in China. Pharmacologic therapy is not the first recommendation because of its safety issues. Non-pharmacologic therapy, such as lifestyle adjustments, weight loss, and proper exercise is strongly recommended to use in knee osteoarthritis. But the adherance rate is very poor. Acupotomy therapy, as an effective treatment for knee osteoarthritis, is lack of high quality randomized controlled trials. This study set out to investigate the efficacy of acupotomy in patients with knee osteoarthritis.Methods136 patients will be enrolled in the First Affiliated Hospital of Guangzhou University of Chinese Medicine, and assigned into acupotomy group or sham acupotomy group according to the block randomization number. The acupotomy group will receive 2 sessions of acupotomy for 2 weeks(once a week). The sham group will receive 2 sessions of sham stimulation for 2 weeks༈once 2 week. All the patients will use indomethacin cream externally. The primary outcome is the WOMAC index and the secondary outcomes are VAS, plantar pressure distribution test, X-ray examination, musculoskeletal ultrasound, maximum knee circumference, and joint mobility. We will measure them at baseline, one week after the end of treatments, the third month and sixth month follow up.DiscussionAs we know, this is the first single-blinding and sham controlled design in acupotomy research. We aim to prove the efficacy of acupotomy in treating knee osteoarthritis.Trial registrationChinese Clinical Trial Registry: ChiCTR2000033047(2020-5-18).
A genome-wide screening for RNAi pathway proteins in Acari
Authors: Nganso Beatrice T , Sela Noa , Soroker Victoria
Published: August 2020

Background RNA interference (RNAi) is a highly conserved, sequence-specific gene silencing mechanism present in Eukaryotes. Three RNAi pathways critical for organismal development and survival are known, namely micro-RNA (miRNA), Piwi-interacting RNA (piRNA) and short interfering RNA (siRNA) pathways. Little knowledge exist about the genes involved in these pathways in Acari. Moreover, variable successes has been obtained in gene knockdown via siRNA pathway in functional genomics and management of Acari species. We hypothesized that the clue may be in the variability in the composition and the efficacy of siRNAi machinery among Acari. Results Both comparative genomic analyses and domain annotation suggest that all the analyzed species have orthologs of genes that mediate gene silencing via the three RNAi pathways though gene duplication and/or loss have occurred in the different species. We also identified orthologs of Caenorhabditis elegans RNA-dependent RNA polymerase (RdRP) gene in all Acari species though no secondary Argonaute homologs that operate with this gene in siRNA amplification mechanism were found. This finding suggests that the siRNA amplification mechanism present in Acari may be distinct from that described in C. elegans . Moreover, the genomes of these Acari species encode no ortholog of C. elegans systemic RNAi defective 1 (Sid-1) that mediate systemic RNAi, suggesting that the phenomena of systemic and parental RNAi that has been reported in some Acari species probably occur through a different mechanism. Orthologs of RNAi spreading defective-3 (Rsd-3) gene and scavenger receptors namely Eater and SR-CI that mediate endocytosis cellular update of dsRNA in C. elegans and Drosophila melanogaster were found in Acari genomes. This result suggests that cellular dsRNA uptake in Acari is endocytosis-dependent. Detailed phylogenetic analyses of core RNAi pathway genes in the studied Acari species revealed that their evolution is compatible with the proposed monophyletic evolution of this group. Conclusions Taken together, our in silico comparative analyses have revealed the potential activity of all three pathways in Acari. However, much experimental work remains to be done in elucidating the operating mechanisms behind these pathways in particular those that govern systemic/parental RNAi and siRNA amplification in Acari.
Recombinant human bone morphogenetic protein -2 in combination with β-Tricalcium Phosphate and Platelet Rich Fibrin for Socket Preservation before Implant Placement
Authors: Durge Khushboo Jeevan , Baliga Vidya Sudhindra , Srid Shilpa Banglore , Dhadse Prasad Vijayrao , Ragit Gayatri Chandrakant
Published: August 2020

Objectives –Periosteum is a rich source of osteoprogenitor cells, and flapless extraction technique allows for preservation of periosteum. Recombinant Bone Morphogenetic Protein-2 has osteoinductive capacity and has been exploited for bone augmentation. The aim of this study is to determine the effectiveness of rhBMP-2 for socket preservation along with β-TCP and PRF to enhance bone quality, clinically and radiographically.Results- Minimal crestal bone changes were seen at 3 months compared to baseline values; bone loss of 0.6 ± 0.13 mm at mesio-distal aspect, 0.5 ± 0.13 mm at bucco-lingual aspect. At 3 months reentry, no residual bone particulate graft were seen in any of site. Clinical hardness of bone evaluated through tactile perception while drilling, prior to implant placement, was analogous to drilling into spruce or white pine wood. Histologic analysis confirmed the absence of residual bone graft indicating new bone formation .Complete radiographic fill was seen at 3 months. The patients in current study showed adequate bone formation in grafted sockets and required no additional augmentation during implant placement. Therefore, based on the results and within the limitations of study it can be suggested that, rhBMP-2 with PRF and β-TCP can be recommended for socket preservation prior to implant placement
Transcription Factor CTCFL Promotes cell Proliferation, Migration and Invasion in Gastric Cancer Via Activating DPPA2
Authors: Yao Haibo , Shao Qinshu , Shao Yanfei
Published: August 2020

Background: The purpose of this study was to explore the relationship between CTCFL and DPPA2, and validate the positive role of CTCFL/DPPA2 in cell proliferation, migration and invasion in gastric cancer.Methods: Bioinformatics methods were applied for the prediction of gastric cancer-related transcription factors and corresponding target mRNAs. qRT-PCR and western blot were performed to test the levels of CTCFL and DPPA2. Then a series of in vitro experiments were conducted to assay the cell biological behaviors, including CCK-8, colony formation assay, wound healing assay and Transwell invasion assay. CHIP was carried out for assessment of the targeted relationship between CTCFL and DPPA2.Results: CTCFL and DPPA2 were both highly expressed in gastric cancer cells, and high CTCFLL and DPPA2 could promote cell proliferation, migration and invasion. CHIP validated that DPPA2 was a target of CTCFL. In addition, high DPPA2 could reverse the inhibitory effect of CTCFL silencing on the cell proliferation, migration and invasion in gastric cancer.Conclusion: The transcription factor CTCFL promotes cell proliferation, migration and invasion in gastric cancer via activating DPPA2.
miR-145-5p Overexpression Inhibits the Proliferation, Migration and Invasion of Esophageal Carcinoma Cells by Targeting ABRACL
Authors: Fan Shengming , Chen Pei , Li Shugang
Published: August 2020

Background: The study aimed to investigate the regulatory relationship between miR-145-5p and ABRACL, and tried to clarify the mechanisms underlying the proliferation, migration and invasion of esophageal cancer (EC) cells.Methods: Gene expression data related to EC were accessed from TCGA database and the “edgeR” package was used to screen the differentially expressed miRNA (DEmiRNAs) and genes (DEGs). TargetScan, miRDB and miRTarBase databases were used to predict potential targets for the target miRNA miR-145-5p. qRT-PCR and Western blot were performed to assess the expression of miR-145-5p and ABRACL in EC cells. Dual-luciferase reporter assay was performed for verification of the targeting relationship between miR-145-5p and ABRACL. Functional experiments including colony formation assay, Transwell migration and invasion assays were used to detect the proliferation, migration and invasion abilities of EC cells. Results: The expression of miR-145-5p was significantly decreased in EC, while ABRACL was remarkably increased. In addition, there was a negative correlation identified between miR-145-5p and ABRACL expression levels. Overexpressing miR-145-5p was able to suppress cell proliferation, migration and invasion, whereas silencing miR-145-5p posed an opposite effect. In the meantime, ABRACL was identified as a direct target of miR-145-5p by dual-luciferase reporter assay. Furthermore, miR-145-5p could inhibit the expression of ABRACL, in turn inhibiting the proliferation, migration and invasion of EC cells. Conclusion: miR-145-5p functions on the proliferation, migration and invasion of EC cells via targeting ABRACL, and it may be a novel therapeutic target for EC treatment.
The monocyte-to-lymphocyte ratio and depression in diabetes patients
Authors: Zhou Depu , Wang Jie , Li Xiaokun
Published: August 2020

Background: The purpose of this study was to determine the association between The monocyte-to-lymphocyte ratio (MLR) and depression with diabetes mellitus.Method: We examined data from the US National Health and Nutrition Examination Survey from 2009 to 2016. Cox proportional hazard models were used to calculate the associations between MLR and depression. For precise investigation of the relationship, we also plotted the smooth curve fit and generated a two-piecewise linear regression model using the penalized spline method.Result: We enrolled 2820 diabetes patients in the database. Diabetes patients who had high MLR tended to be young, female, obese, unmarried, and had low levels of education. For tertile analysis, the ORs and 95% CIs of clinically relevant depression in tertile analysis were 1.03 (0.91, 1.17) for the second group and 1.62 (1.44, 1.82) for the third group in the unadjusted model compared to the control group. A similar trend was observed for the adjusted model and the quartiles analysis. We found the inflection point of MLR was 2.7. There is a positive association between MLR and depression above the threshold, and no relationship was found when MLR was below the threshold in diabetes patients. Conclusion: There is a nonlinear relationship between MLR and depression in diabetes patients. High level of MLR more than the inflection point may add prognostic information for depression in diabetes patients.
Riverbank Erosion and Migration, Inter-linkage: With Special Focus on Assam, India
Authors: Dekaraja Dimpal , Mahanta Ratul
Published: August 2020

Background: River-bank erosion becomes a vulnerable phenomenon in the bank of the Brahmaputra river and its tributaries. Around 17 riverine districts of Assam are affected by riverbank erosion and lost large plots of land. Due to riverbank erosion the victims’ loss their homestead and crop land as well as their survival strategy in the eroded areas. Moreover, farmers largely affected due to riverbank erosion as they loss their sources of income. This forces the farmer to migrate to another place for their survival. The paper examines the linkage between river bank erosion and migration based on secondary information. To examine the linkage, information collected from government published source ‘Census of India’ and ‘Statistical handbook of Assam’. On the basis of the information, 10 indicators constructed from 26 variables and then factor analysis method applied to examine the linkage between riverbank erosion and migration. Results: Four variables that are agricultural worker, industrial worker, cropped area and livestock population are loaded into the first factor, for which the first factor is labeled as the socio-economic indicator. In case of second factor the two variables i.e. MGI and urban population are loaded. On the basis of the loaded variables this factor labeled as demographic indicator. In case of third factor also two variables are loaded that is, NGI (Natural Growth Index) and Literacy rate. The loaded variables indicate that both NGI and Literacy rate are positively related. Two variables are loaded in this fourth factor i.e. river bank eroded area and the district population growth. This factor labeled as environmental indicator on the basis of the variables loaded in this factor. The factor correlation matrix indicate the opposite relation between first and fourth factor.Conclusion: The results obtained from Factor component analysis reveals that the first and fourth factor component mainly established the linkage between riverbank erosion and migration. Besides this the component correlation matrix also reveals the inter-linkage between the variables. Thus we can say that there is positive relation between riverbank erosion and migration. However, it can be interpret that farmers mostly affected due to riverbank erosion and migrate more, because farmers mostly inhabited in floodplain areas.
Does persistent meditation and physical activity mediate the relationship between perceptions of COVID-19 and mental health? A cross sectional survey of mobile app users in the United States.
Authors: Green Jeni , Huberty Jennifer , Puzia Megan , Stecher Chad
Published: August 2020

Background: The Coronavirus Disease 2019 (COVID-19) pandemic has been declared an international public health emergency with potential long-lasting effects on mental health. The purpose of this survey was to examine the regional differences in mental health and perceptions of COVID-19 in light of the state-level prevalence of COVID-19 cases, estimate the associations between perceptions of COVID-19 and health behavior engagement (i.e., physical activity, mindfulness meditation) and mental health, and explore the mediating effect of health behavior engagement on the relationship between perceptions of COVID-19 and mental health.Methods: A cross-sectional survey was distributed to a sample of US adult paying subscribers to the Calm app (data collection April 22 to June 3, 2020). The survey assessed perceptions of COVID-19, health behavior engagement, and mental health (i.e., perceived stress, post-traumatic stress disorder, and anxiety and depression). All statistical analyses were performed using R software. Differences in perceptions of COVID-19 and mental health by location were assessed using t-tests and chi-square tests. Logistic and OLS models regressed mental health and health behavior on COVID-19 perceptions, and Causal Mediation Analysis was used to estimate the significance of mediation effects. Results: Median age (N=8392) was 47 (SD=13.8) years. Mid-Atlantic region participants reported higher levels of stress, more severe depression symptoms, were more worried about COVID-19, paid more attention to COVID-19 news, and had more stress related to social distancing recommendations than participants living in other regions. The relationship between worry about COVID-19 and perceived stress was significantly mediated by changes in physical activity (p<.001) and strength of meditation habit (p<.001). The relationship between worry about COVID-19 and PTSD symptoms was significantly mediated by changes in physical activity (p<.001) and strength of meditation habit (p<.001). Conclusions: Our findings describe the mental health impact of COVID-19 and outline how continued participation in health behaviors such as physical activity and mindfulness meditation may buffer against worsening mental health due to the COVID-19 pandemic. These data have important implications for public health agencies and health organizations to promote the maintenance of health habits to reduce the residual mental health burden of the COVID-19 pandemic.
Accuracy of remote diagnoses using intraoral scans captured in approximate true color: a pilot and validation study in teledentistry
Authors: Steinmeier Sabrina Jenny , Wiedemeier Daniel , Hämmerle Christoph HF , Mühlemann Sven
Published: August 2020

Background: Intraoral scans (IOS) provide three-dimensional images with approximate true colors representing a possible tool in teledentistry for remote examination. The aim of the present cross-sectional validation study was, therefore, to evaluate the levels of agreement between remote diagnoses derived from IOS and diagnoses based on clinical examinations for assessing dental and periodontal conditions.Methods: The test sample comprised 10 patients representing different clinical conditions. Following the acquisition of IOS (Trios, 3Shape), a full-mouth dental and periodontal examination was done and periapical radiographs were taken. Ten dentists were asked to perform dental and periodontal scorings for each of the ten patients on a tablet computer presenting the IOS. Scores included diagnosis of gingivitis/periodontitis, and evaluated presence as well as amount of plaque and calculus, and presence of teeth exhibiting gingival recession, furcation involvement, erosion, tooth wear, stain, and non-carious cervical lesion, as well as presence of decayed, filled, and crowned teeth and implants. In a second round of assessments, the periapical radiographs were provided and the dentists were able to change the scores. The time for the remote assessment was recorded. The agreement between remote and clinical scorings (reference) was then analyzed descriptively.Results: The mean time for the tele assessment was 3.17 minutes and the additional consultation of the radiographs accounted for another 1.48 minutes. The sensitivity and specificity values were 0.61 and 0.39 for gingivitis and 0.67 and 0.33 for periodontitis, with no relevant changes when radiographs were provided for the diagnosis of periodontitis (0.72 and 0.28). The agreement for dichotomized dental and periodontal indices ranged between 78 and 95%. With the provision of radiographs, the remote examiners were able to detect existing filled teeth, crowned teeth, and implants, whereas the detection of decayed teeth (70%) was not improved.Conclusions: The remote examination using IOS was effective in detecting dental findings, whereas periodontal conditions could not be assessed with the same accuracy. Still, remote assessment of IOS would allow a time-efficient screening and triage of patients. Improvement of the image quality of IOS may further allow to increase the accuracy of remote assessments in dentistry.Trial registration: BASEC-Nr. Req-2019-01277
Mediating role of prenatal depression in attachment and maternal-fetal attachment in women who receive prenatal education
Authors: Zhang Ling , Wang Lei , Yuan Qiuyu , Cui Shu , Huang Cui , Zhang Kai , Zhou Xiaoqin
Published: August 2020

Background

Prenatal depression and attachment are factors that affect the establishment of an intimate relationship between a mother and fetus, and prenatal education plays an important role in helping pregnant women adapt to a maternal role and changes during pregnancy. The study explored differences in prenatal depression and maternal-fetal attachment (MFA) scores between a prenatal education group and no prenatal education group, as well as the effects of maternal depression scores and attachment dimensions on maternal intimacy with the fetus.
Methods

The Edinburgh Postnatal Depression Scale (EPDS), Experience of Close Relationship (ECR) scale, Maternal Antenatal Attachment Scale (MAAS) and a general data scale were used to investigate 222 pregnant women who received prenatal education and 118 pregnant women who did not receive prenatal education in the third trimester of pregnancy. An exploratory analysis was performed to analyze the effects of depression score and attachment on MFA in pregnant women who received prenatal education.
Results

The results showed that pregnant women who received prenatal education had higher MFA and lower depression scores than those who did not receive prenatal education, and prenatal depression partially mediated the relationship between attachment avoidance and MFA quality.
Conclusions

Women who received prenatal education had low prenatal depression scores and high MFA. Maternal depression and attachment avoidance may affect the emotional bond between mother and fetus and should be taken seriously; they can be prevented by prenatal education and early intervention.
Gravitational-Wave Implications for the Parity Symmetry of Gravity at GeV Scale
Authors: Wang Yifan , Niu Rui , Zhao Wen , Zhu Tao
Published: August 2020

Einstein's general relativity, as the most successful theory of gravity, is one of the cornerstones of modern physics. However, the experimental tests for gravity in the high energy region are limited. The emerging gravitational-wave astronomy has opened an avenue for probing the fundamental properties of gravity in strong and dynamical field, and in particular, high energy regime. In this work, we focus on the parity symmetry of gravity. For broken parity, the left- and right-handed modes of gravitational waves would follow different equations of motion, dubbed as birefringence. We perform the first full Bayesian inference of the parity conservation of gravity by comparing the state-of-the-art waveform with the compact binary coalescence data released by LIGO and Virgo collaboration. We do not find any violations of general relativity, thus obtain the lower bound of the parity-violating energy scale to be $0.09$ GeV through the velocity birefringence of gravitational waves. This provides the most stringent experimental test of gravitational parity symmetry up to date, and for the first time, in the high energy region, which ushers in a new era of using gravitational waves to test the ultraviolet behavior of gravity.
We also find third-generation gravitational-wave detectors can enhance this bound to $\mathcal{O}(10^2)$ GeV if there is still no violation, comparable to the current LHC energy scale in particle physics.
dom2vec: Capturing domain structure and function using self-supervision on protein domain architectures
Authors: Melidis Damianos P. , Malone Brandon , Nejdl Wolfgang
Published: August 2020

Background: Word embedding approaches have revolutionized natural language processing (NLP) research. These approaches aim to map words to a low-dimensional vector space, in which words with similar linguistic features cluster together. Embedding-based methods have also been developed for proteins, where words are amino acids and sentences are proteins. The learned embeddings have been evaluated qualitatively, via visual inspection of the embedding space and extrinsically, via performance comparison on downstream protein prediction tasks. However, these sequence embeddings have the caveat that biological metadata do not exist for each amino acid, in order to measure the quality of each unique learned embedding vector. Results: Here, we present dom2vec, an approach for learning protein domain embeddings using word2vec on InterPro annotations. In contrast to sequence embeddings, biological metadata do exist for protein domains, related to each domain separately. Therefore, we present four intrinsic evaluation strategies to quantitatively assess the quality of the learned embedding space. To perform a reliable evaluation in terms of biology knowledge, we selected the metadata related to the most distinctive biological characteristics of domains. These are the structure, enzymatic and molecular function of a given domain. Notably, dom2vec obtains adequate level of performance in the intrinsic assessment, therefore we can draw an analogy between the local linguistic features in natural languages and the domain structure and function information in domain architectures. Moreover, we demonstrate the dom2vec applicability on protein prediction tasks, by comparing it with state-of-the-art sequence embeddings in three downstream tasks. We show that dom2vec outperform sequence embeddings for toxin and enzymatic function prediction and is comparable with sequence embeddings in cellular location prediction. Conclusions: We report that the application of word2vec on InterPro annotations produces domain embeddings with two significant advantages over sequence embeddings. First, each unique dom2vec vector can be quantitatively evaluated towards its available structure and function metadata. Second, the produced embeddings can outperform the sequence embeddings for a subset of downstream tasks. Overall, dom2vec embeddings are able to capture the most important biological properties of domains and surpass sequence embeddings for a subset of prediction tasks.