bluuebunny/crossref_metadata_2025 huggingface dataset:
Transcatheter closure of patent ductus arteriosus in preterm infants: results from a single-center cohort
Authors: Honnorat Marion , Perouse-De-Montclos Thomas , Bakloul Mohamed , Walton Camille , Butin Marine , Vo Van Philippe
Published: December 2023

Objective

To assess the success rate of patent ductus arteriosus (PDA) transcatheter closure in preterm infants and to describe the nature of procedural adverse events and short-term clinical status.

Study design

All the preterm infants with PDA transcatheter closure were evaluated retrospectively between July 2019 and March 2023 in a single level III neonatal intensive care unit in France. The procedure was performed in the catheterization laboratory using venous canulation. We retrospectively collected data about the patients' characteristics, procedural outcomes and complications.

Results

Twenty-five infants born between 23.4 and 32.0 weeks of gestational age (mean ± SD 26.3 ± 1.9 weeks) underwent transcatheter PDA closure. Their mean age and weight at the time of the procedure were 52 days (range 22–146 days) and 1,620 g (range 890–3,700 g), respectively. Successful closure was achieved in all but one patient. Procedure related complications were reported in 10 infants (40%), including 6 left pulmonary artery stenosis one of which required a balloon dilatation, two cardiac tamponades and two inferior vena cava thrombosis. Only two post-ligature syndromes occurred after the procedure. Two infants died one of which was related to the procedure.

Conclusion

Transcatheter closure of a PDA is a valid alternative to surgical ligation due to its high success rate and low incidence of post-ligature syndrome. Nevertheless, we also report rare, although serious complications.
Exogenous glutathione reverses meropenem resistance in carbapenem-resistant Klebsiella pneumoniae
Authors: Yi Juan , Liu Chao , Yang Ping , Wu Zhen-chao , Du Chun-jing , Shen Ning
Published: December 2023

Background: The rate of carbapenem-resistant Klebsiella pneumoniae (CRKP) infection has been increasing rapidly worldwide and, poses a significant risk to human health. Effective methods are urgently needed to address treatment failures related to antibiotic resistance. Recent research has reported that some drugs in combination with antibiotics have displayed synergistic killing of resistant bacteria. Here, we investigated whether glutathione (GSH) can synergize with meropenem, and enhance its effectiveness against CRKP.

Methods: Synergistic activity was assessed by checkerboard and time-killing assays. The mechanism of these combinations was assessed by total ROS and membrane permeability assays. The bacterial metabolites were assessed by LC‒MS/MS.

Results: The FICIs of GSH and meropenem were approximately 0.5 and the combined treatment with GSH and meropenem resulted in a more than 2log10 CFU/mL reduction in bacteria compared to the individual treatments. These findings indicated the synergistic effect of the two drugs. Moreover, the meropenem MIC of CRKP was reduced to less than 4 mg/L when combined with 6 mg/mL GSH, indicating that GSH could significantly reverse resistance to meropenem in bacteria. The production of ROS in bacteria was determined by flow cytometry. After adding GSH, the ROS in the GSH group and the combined group was significantly higher than that in the control and meropenem groups, but there was no significant difference between the combined and GSH groups. The metabolic disturbance caused by GSH alone and in combination with meropenem was significant intracellularly and extracellularly, especially in terms of glycerophospholipid metabolism, indicating that the synergistic effect of the combined use of GSH and meropenem was relevant to glycerophospholipid metabolism. In addition, we measured the cell membrane permeability. The cell membrane permeability of the combination group was significantly higher than that of the blank control or monotreatment groups. This confirmed that the GSH can serve as a meropenem enhancers by disturbing glycerophospholipid metabolism and increasing cell membrane permeability.

Conclusion: GSH and meropenem display a synergistic effect, wherein GSH increases the sensitivity of CRKP to meropenem. The synergy and susceptibility effects are thought to related to the increased membrane permeability resulting from the perturbations in glycerophospholipid metabolism, presenting a novel avenue for CRKP treatment.
Breaking the barriers: overcoming dementia-related stigma in minority communities
Authors: Siette Joyce , Meka Anjani , Antoniades Josefine
Published: December 2023

Dementia is a global health concern that affects individuals irrespective of their cultural or linguistic backgrounds. However, research has long recognized the pronounced stigma associated with dementia, particularly within Culturally and Linguistically Diverse (CALD) communities. This article seeks to summarize the underlying factors contributing to the heightened levels of dementia stigma within CALD communities, through a review of the literature. Our examination shows that cultural beliefs, language barriers, limited awareness, and the impact of migration on perceptions of aging and cognitive decline are contributing factors. Consequently, our analysis highlights the need for tailored, culturally appropriate interventions aimed at mitigating stigma and enhancing dementia care within CALD populations. Our proposed solutions, built on a social-ecological approach, highlights the critical role of collaborative efforts involving policymakers, healthcare providers, community organizations, and CALD community members in fostering a more dementia-inclusive society. This perspective piece aims to shed light on the distinct challenges faced by CALD communities, while advocating for a holistic approach to redefine perceptions and care strategies tailored to these populations.
A Survey on Swarm Robotics for Area Coverage Problem
Authors: Muhsen Dena Kadhim , Sadiq Ahmed T. , Raheem Firas Abdulrazzaq
Published: December 2023

The area coverage problem solution is one of the vital research areas which can benefit from swarm robotics. The greatest challenge to the swarm robotics system is to complete the task of covering an area effectively. Many domains where area coverage is essential include exploration, surveillance, mapping, foraging, and several other applications. This paper introduces a survey of swarm robotics in area coverage research papers from 2015 to 2022 regarding the algorithms and methods used, hardware, and applications in this domain. Different types of algorithms and hardware were dealt with and analysed; according to the analysis, the characteristics and advantages of each of them were identified, and we determined their suitability for different applications in covering the area for many goals. This study demonstrates that naturally inspired algorithms have the most significant role in swarm robotics for area coverage compared to other techniques. In addition, modern hardware has more capabilities suitable for supporting swarm robotics to cover an area, even if the environment is complex and contains static or dynamic obstacles.
Research on Ensemble Learning-Based Feature Selection Method for Time-Series Prediction
Authors: Huang Da , Liu Zhaoguo , Wu Dan
Published: December 2023

Feature selection has perennially stood as a pivotal concern in the realm of time-series forecasting due to its direct influence on the efficacy of predictive models. Conventional approaches to feature selection predominantly rely on domain knowledge and experiential insights and are, therefore, susceptible to individual subjectivity and the resultant inconsistencies in the outcomes. Particularly in domains such as financial markets, and within datasets comprising time-series information, an abundance of features adds complexity, necessitating adept handling of high-dimensional data. The computational expenses associated with traditional methodologies in managing such data dimensions, coupled with vulnerability to the curse of dimensionality, further compound the challenges at hand. In response to these challenges, this paper advocates for an innovative approach—a feature selection method grounded in ensemble learning. The paper explicitly delineates the formal integration of ensemble learning into feature selection, guided by the overarching principle of “good but different”. To operationalize this concept, five feature selection methods that are well suited to ensemble learning were identified, and their respective weights were determined through K-fold cross-validation when applied to specific datasets. This ensemble method amalgamates the outcomes of diverse feature selection techniques into a numeric composite, thereby mitigating potential biases inherent in traditional methods and elevating the precision and comprehensiveness of feature selection. Consequently, this method improves the performance of time-series prediction models.
Retrieval of Aerosol Optical Depth and FMF over East Asia from Directional Intensity and Polarization Measurements of PARASOL
Authors: Wang Shupeng , Fang Li , Gong Weishu , Wang Weihe , Tang Shihao
Published: December 2023

The advantages of performing aerosol retrieval with multi-angle, multi-spectral photopolarimetric measurements over intensity-only measurements come from this technique’s sensitivity to aerosols’ microphysical properties, such as their particle size, shape, and complex refraction index. In this study, an extended LUT (Look Up Table) algorithm inherited from a previous work based on the assumption of surface reflectance spectral shape invariance is proposed and applied to PARASOL (Polarization and Anisotropy of Reflectances for Atmospheric Science coupled with Observations from a Lidar) measurements to retrieve aerosols’ optical properties including aerosol optical depth (AOD) and aerosol fine-mode fraction (FMF). Case studies conducted over East China for different aerosol scenes are investigated. A comparison between the retrieved AOD regional distribution and the corresponding MODIS (Moderate-resolution Imaging Spectroradiometer) C6 AOD products shows similar spatial distributions in the Jing-Jin-Ji (Beijing–Tianjin–Hebei, China’s mega city cluster) region. The PARASOL AOD retrievals were compared against the AOD measurements of seven AERONET (Aerosol Robotic Network) stations in China to evaluate the performance of the retrieval algorithm. In the fine-particle-dominated regions, lower RMSEs were found at Beijing and Hefei urban stations (0.16 and 0.18, respectively) compared to those at other fine-particle-dominated AERONET stations, which can be attributed to the assumption of surface reflectance spectral shape invariance that has significant advantages in separating the contribution of surface and aerosol scattering in urban areas. For the FMF validation, an RMSE of 0.23, a correlation of 0.57, and a bias of −0.01 were found. These results show that the algorithm performs reasonably in distinguishing the contribution of fine and coarse particles.
Effect of Different Anchorage Reinforcement Methods on Long-Term Maxillary Whole Arch Distalization with Clear Aligner: A 4D Finite Element Study with Staging Simulation
Authors: Mao Bochun , Tian Yajing , Xiao Yujia , Liu Jiayi , Liu Dawei , Zhou Yanheng , Li Jing
Published: December 2023

The objective of this study was to examine how various anchorage methods impact long-term maxillary whole arch distalization using clear aligners (CAs) through an automated staging simulation. Three different anchorage reinforcement methods, namely, Class II elastics, buccal temporary anchorage device (TAD), and palatal TAD, were designed. Orthodontic tooth movement induced by orthodontic forces was simulated using an iterative computation method. Additionally, the automatic adjustment of the CA was simulated through the application of the thermal expansion method. The results indicated that the palatal TAD group had the largest retraction of incisors, followed by the buccal TAD group and the Class II elastic group, while the least was in the control group. The largest distal displacements and efficiency of molar distalization for the first and the second molars were noticed in the palatal TAD group. Arch width increased at the molar and premolar levels in all groups. The FEM results suggested palatal TAD had the best performance considering anterior teeth anchorage maintenance, both sagittally and vertically. However, attention should be paid to the possible increasement of arch width.
Overexpression of Growth Differentiation Factor 15 in Glioblastoma Stem Cells Promotes Their Radioresistance
Authors: Bentaberry-Rosa Alexandre , Nicaise Yvan , Delmas Caroline , Gouazé-Andersson Valérie , Cohen-Jonathan-Moyal Elizabeth , Seva Catherine
Published: December 2023

GSCs play an important role in GBM recurrence. Understanding the resistance mechanisms in these cells is therefore crucial for radiation therapy optimization. In this study, using patient-derived GSCs, we demonstrate that GDF15, a cytokine belonging to the TGF-β superfamily, is regulated by irradiation (IR) and the transcription factor WWTR1/TAZ. Blocking WWTR1/TAZ using specific siRNAs significantly reduces GDF15 basal expression and reverses the upregulation of this cytokine induced by IR. Furthermore, we demonstrate that GDF15 plays an important role in GSC radioresistance. Targeting GDF15 expression by siRNA in GSCs expressing high levels of GDF15 sensitizes the cells to IR. In addition, we also found that GDF15 expression is critical for GSC spheroid formation, as GDF15 knockdown significantly reduces the number of GSC neurospheres. This study suggests that GDF15 targeting in combination with radiotherapy may be a feasible approach in patients with GBM.
Expression and Localization of Ferritin-Heavy Chain Predicts Recurrence for Breast Cancer Patients with a BRCA1/2 Mutation
Authors: Qu Shuoying , Timmermans A. Mieke , Heemskerk-Gerritsen Bernadette A. M. , Trapman-Jansen Anita M. A. C. , Broeren-Foekens Renée , Prager-van der Smissen Wendy J. C. , El Hassnaoui Hoesna , van Tienhoven Tim , Bes-Stobbe Claudia K. , Westenend Pieter J. , van Deurzen Carolien H. M. , Martens John W. M. , Hooning Maartje J. , Hollestelle Antoinette
Published: December 2023

The ferritin-heavy chain (FTH1) is the catalytic subunit of the ferroxidase ferritin, which prevents oxidative DNA damage via intracellular iron storage. FTH1 was shown to be a prognostic marker for triple-negative breast cancer (BC) patients and associated with an enrichment of CD8+ effector T cells. However, whether the expression and localization of FTH1 are also associated with clinical outcome in other BC subtypes is unknown. Here, we investigated the association of FTH1 with time to survival in BCs from 222 BRCA1/2 mutation carriers by immunohistochemistry on tissue microarrays. In addition, for 51 of these patients, the association between FTH1 and specific subsets of T cells was evaluated on whole slides using automatic scoring algorithms. We revealed that nuclear FTH1 (nFTH1) expression, in multivariable analyses, was associated with a shorter disease-free (HR = 2.71, 95% CI = 1.49–4.92, p = 0.001) and metastasis-free survival (HR = 3.54, 95% CI = 1.45–8.66, p = 0.006) in patients carrying a BRCA1/2 mutation. However, we found no relation between cytoplasmic FTH1 expression and survival of BRCA1/2 mutation carriers. Moreover, we did not detect an association between FTH1 expression and the amount of CD45+ (p = 0.13), CD8+ (p = 0.18), CD4+ (p = 0.20) or FOXP3+ cells (p = 0.17). Consequently, the mechanism underlying the worse recurrence-free survival of nFTH1 expression in BRCA1/2 mutation carriers needs further investigation.
A Comprehensive Review of Genistein’s Effects in Preclinical Models of Cervical Cancer
Authors: Nadile Matteo , Kornel Amanda , Sze Newman Siu Kwan , Tsiani Evangelia
Published: December 2023

Cervical cancer is associated with persistent Human Papilloma Virus (HPV) infections and is the fourth most common cancer in women worldwide. Current treatment options; surgery, chemotherapy, and radiation, are often associated with severe side effects including possible infertility. Novel treatment options are required to help combat this disease and reduce side effects. Many plant-derived chemicals, including paclitaxel and docetaxel, are already in use as treatments for various cancers. Genistein is a polyphenolic isoflavone found in foods including soybeans and legumes, and studies have shown that it has various biological effects and anti-cancer properties. This review aims to summarize the existing studies examining the effects of genistein on cervical cancer. All relevant in vitro and in vivo studies are summarized, and the key findings are highlighted in the associated tables. Based on the available in vitro/cell culture studies reported here, genistein inhibits cervical cancer cell proliferation and induces apoptosis. Use of genistein in combination with radiation or chemotherapy agents resulted in enhanced response indicating radio- and chemo-sensitization properties. More animal studies are required to examine the effectiveness of genistein in vivo. Such studies will form the basis for future human studies exploring the potential of genistein to be used in the treatment of cervical cancer.
Parenchyma Sparing Anatomic Liver Resections (Bi- and Uni-Segmentectomies) for Liver Tumours in Children—A Single-Centre Experience
Authors: Murawski Maciej , Garnier Hanna , Stefanowicz Joanna , Sinacka Katarzyna , Izycka-Swieszewska Ewa , Sawicka-Zukowska Malgorzata , Wawrykow Pawel , Wrobel Grazyna , Mizia-Malarz Agnieszka , Marciniak-Stepak Patrycja , Czauderna Piotr
Published: December 2023

Purpose: To present a single-centre experience in bi- and uni-segmentectomies for primary liver tumours in children. Methods: This study included 23 patients that underwent (bi)segmentectomy. There were 15 malignant tumours (hepatoblastoma—13 patients), 7 benign tumours, and 1 calcifying nested stromal epithelial tumour. Results: The median tumour diameter was 52 mm (range 15–170 mm). Bisegmentectomy 2–3 was most frequently performed (seven patients), followed by bisegmentectomy 5–6 (four patients). The median operative time was 225 min (range 95–643 min). Intraoperative complications occurred in two patients—small bowel perforation in one and an injury of the small peripheral bile duct resulting in biloma in the other. The median resection margin in patients with hepatoblastoma was 3 mm (range 1–15 mm). Microscopically negative margin status was achieved in 12 out of 13 patients. There were two recurrences. After a median follow-up time of 38 months (range 12–144 months), all 13 patients with HB were alive with no evidence of disease. Two relapsed patients were alive with no evidence of disease. Conclusions: From the available literature and data presented here, we propose that (bi)segmentectomy can become a viable surgical option in carefully selected paediatric patients and is sufficient to achieve a cure. Further studies evaluating the impact of parenchymal preservation surgery on surgical and oncological outcome should be conducted with a larger dataset.
Overcoming Resistance Mechanisms to Immune Checkpoint Inhibitors: Leveraging the Anti-Tumor Immune Response
Authors: Coschi Courtney H. , Juergens Rosalyn A.
Published: December 2023

As far back as 3000 years ago, the immune system was observed to play a role in mediating tumor regression. Since then, many strategies have been developed to leverage the anti-tumor immune response. However, while many patients respond to ICIs up front some do not, and many of those that do eventually experience tumor progression. Currently, there are several predictive biomarkers of the immune checkpoint inhibitor response; however, no one test appears to be universally predictive and their application varies by disease site. There are many ways in which cancer cells develop primary or acquired resistance to immune checkpoint inhibitors. Efforts to reverse resistance include ways to combat T cell exhaustion, reprogram the tumor microenvironment, increase the availability of tumor neo-antigens, target alternative immune checkpoints, restore a normal/healthy patient gut microbiome, oncolytic viruses and tumor vaccines. The most studied and most promising methods include combining ICIs with therapies targeting alternative immune checkpoints and restoring a normal/healthy patient gut microbiome. This review will discuss T cell-mediated immunity, how this is leveraged by modern immunotherapy to treat cancer and mechanisms of immune checkpoint inhibitor resistance, while highlighting strategies to overcome primary and secondary resistance mechanisms.
RETRACTED: Yang et al. An Adaptive Hierarchical Network Model for Studying the Structure of Economic Network. Entropy 2022, 24, 702
Authors: Yang Xiaoteng , Wu Zhenqiang , Javaid Shumaila
Published: December 2023

This journal retracts the article, ‘An Adaptive Hierarchical Network Model for Studying the Structure of Economic Network’ [...]
Design and Optimization of an Alkaline Electrolysis System for Small-Scale Hydropower Integration
Authors: Song Hojun , Kim Yunji , Yang Heena
Published: December 2023

Alkaline electrolysis systems are currently considered to be suitable for large-scale hydrogen production. Previous research has primarily focused on integrating renewable energy sources such as solar and wind into water electrolysis systems. However, intermittent issues stemming from the sporadic nature of renewable energy sources have led to the introduction of energy storage systems (ESSs) to address these intermittent challenges. Extensive research has been conducted on the efficiency and operational aspects of these systems. In contrast to other renewable energy sources, hydropower offers the advantages of stable output and high utilization, making it a promising solution for overcoming intermittent issues. In this study, we propose the design of an optimized alkaline electrolysis system tailored for small-scale hydropower generation. This approach allowed us to confirm the efficiency of a small-scale hydropower-based hydrogen production facility and the analysis of hydrogen production costs under diverse scenarios. Notably, the optimal selling price per kilogram of hydrogen was determined to be USD 15.6 when the operational time exceeded 20 h, albeit indicating a challenging market supply. Under the consideration of various scenarios and government subsidies, this study revealed that a USD 10/kgH2 subsidy or 24 h of continuous operation achieved break-even points in the sixth and eighth years, respectively. Ultimately, the findings underscore the necessity for essential measures, including government backing and technological advancements in small-scale hydropower facilities, to enhance the economic viability of the green hydrogen market in South Korea.
Molten Salts Tanks Thermal Energy Storage: Aspects to Consider during Design
Authors: Prieto Cristina , Blindu Adrian , Cabeza Luisa F. , Valverde Juan , García Guillermo
Published: December 2023

Concentrating solar power plants use sensible thermal energy storage, a mature technology based on molten salts, due to the high storage efficiency (up to 99%). Both parabolic trough collectors and the central receiver system for concentrating solar power technologies use molten salts tanks, either in direct storage systems or in indirect ones. But even though this is a mature technology, it still shows challenges in its implementation and operation. This paper underscores the critical importance of stringent design criteria for molten salt tanks in thermal storage technology. Focusing on the potential ramifications of design failures, the study explores various dimensions where an inadequate design can lead to severe consequences, even jeopardizing the viability of the entire technology. Key areas discussed include structural integrity, corrosion, thermal shock, thermal expansions, and others. By elucidating the multifaceted risks associated with design shortcomings, this paper aims to emphasize the necessity of thorough reviews and adherence to robust design principles for ensuring the success, safety, and sustainability of thermal storage technology.
A Design Optimization of Organic Rankine Cycle Turbine Blades with Radial Basis Neural Network
Authors: Seo Jong-Beom , Lee Hosaeng , Han Sang-Jo
Published: December 2023

In the present study, a 100 kW organic Rankine cycle is suggested to recover heat energy from commercial ships. A radial-type turbine is employed with R1233zd(E) and back-to-back layout. To improve the performance of an organic Rankine power system, the efficiency of the turbine is significant. With the conventional approach, the optimization of a turbine requires a considerable amount of time and involves substantial costs. By combining design of experiments, an artificial neural network, and Latin hypercube sampling, it becomes possible to reduce costs and achieve rapid optimization. A radial basis neural network with machine learning technique, known for its advantages of being fast and easily applicable, has been implemented. Using such an approach, an increase in efficiency greater than 1% was achieved with minimal design changes at the first and second turbines.
Organisation of the Structure and Functioning of Self-Sufficient Distributed Power Generation
Authors: Hotra Oleksandra , Kulyk Mykhailo , Babak Vitalii , Kovtun Svitlana , Zgurovets Oleksandr , Mroczka Janusz , Kisała Piotr
Published: December 2023

During the operation of solar and wind power plants, it is necessary to solve issues related to the guaranteed capacity of these plants, as well as the frequency stabilisation in the power system where they operate, and maintain an operating mode of self-sufficiency conditions. One of the solutions to these problems is the use of energy storage systems. This article proposes a mathematical model for the study of frequency and power regulation processes in power systems with distributed generation, which includes renewable energy resources and energy storage systems. The novelty of the model lies in the possibility of determining energy cost indicators based on instantaneous energy power data. The model allows us to estimate the conditions under which distributed generation becomes self-sufficient. The results of the model calculations of two variants of power system operation, which includes wind generators with a capacity of 1500 MW, demonstrate the ability of the proposed model to accurately reproduce the dynamics of the frequency stabilisation process. The calculation results of the energy-economic indicators of a real power system combined with a powerful subsystem of wind generation and a battery-type energy storage system prove the competitiveness of self-sufficient renewable energy power plants.
Comprehensive Analysis of Dual-Rotor Yokeless Axial-Flux Motor with Surface-Mounted and Halbach Permanent Magnet Array for Urban Air Mobility
Authors: Hong Do-Kwan , Park Jang-Hyun , Jeong Yeon-Ho
Published: December 2023

A dual-rotor yokeless and segmented armature (YASA)-type axial-flux permanent magnet (AFPM) motor with a surface-mounted permanent magnet (SPM) array type was developed for urban air mobility (UAM) aircraft in this work. The proposed AFPM motor had rated and peak output powers of 75.5 and 104 kW, respectively, with rated and peak rotational speeds of 1800 rpm. To achieve a high torque, a cobalt–iron alloy core material was used for the stator core. The prototype AFPM motor, developed by KSEP in the Republic of Korea, was successfully manufactured and verified through experimentation. Additionally, the thermal stability of the winding and permanent magnets (PMs) was confirmed with a water-cooling system. A structure analysis of the proposed AFPM motor was conducted due to the detachment of an uneven air-gap length in the prototype AFPM motor. An output performance comparison based on core materials for the stator and rotor was carried out to explore the material cost reduction. Subsequently, the design for performance improvement by applying a Halbach permanent magnet (HPM) array type was investigated for further research.
Structural Behavior of a PIP Slip Joint under Pure Bending Considering Nonlinear Buckling
Authors: Islam Md Ariful , Park Hongbae , Lee Daeyong
Published: December 2023

This study investigates the structural behavior of a particular mechanical joint subjected to bending and perturbation and the selection of overlapping lengths for this CHS structure arrangement. We began this research by meticulously validating the methodology through a rigorous replication of a prior experimental study, establishing its reliability as a solid foundation. Subsequently, the process was applied to pile-in-pile (PIP) slip joints with varying overlapping lengths. The primary aim was to determine the optimal overlapping length, a critical parameter in this analysis, encompassing the evaluation of stiffness, bending capacities, and joint efficacy. These investigations reveal a clear correlation between increasing overlapping length and heightened joint stiffness. An optimal overlapping length that strikes a harmonious balance between stiffness, bending capacity, and joint efficiency was identified. These findings hold substantial promise for enhancing the joint design of tubular sections, particularly within the context of wind-turbine structures. Using this novel joint can be promising in increasing the efficiency and reliability of CHS structures in future construction and performance.
Pilot Study of 3D Spatial Distribution of α-Pinene Emitted by Norway Spruce (L.) Karst Recently Infested by Ips typographus (L. 1758) (Coleoptera: Scolytinae)
Authors: Stříbrská Barbora , Moliterno Antonioni Acacio Campos , Hüttnerová Tereza , Leiner Martin , Surový Peter , Jirošová Anna
Published: December 2023

The Eurasian Spruce Bark Beetle (Ips typographus) (L. 1758) (Coleoptera: Scolytinae) poses a significant threat to Eurasia’s Norway spruce (Picea abies) (L.) Karst, forests. Early detection of infested trees is crucial to control beetle outbreaks and allow salvage logging before the next generation emerges. Besides traditional methods, new approaches focus on monitoring volatile organic compounds, mainly monoterpenes, emitted by infested trees. Using analytical chemistry, we studied the distribution of these compounds, particularly α-pinene, around infested trees. In lab trials, we optimized α-pinene detection using dynamic absorption and solid-phase microextraction (SPME), analyzed by gas chromatography with flame ionization detection (GC-FID). We conducted forest trials, revealing varying α-pinene abundance due to changing conditions. However, consistent trends emerged: levels were highest near the infested tree stem and 1.3 m above ground in the first trial and at a 1 m distance from the infested stem in the second. We generated a three-dimensional cloud depicting the distribution of α-pinene around infested trees in their natural habitat. These findings open avenues for detecting bark beetles on a large scale by mapping elevated concentrations of volatile organic compounds emitted by infested trees, potentially leading to alternative pest management methods. Scanning methods, such as electronic sensors combined with remote sensing, hold promise for this application.
The Impact of Permafrost Change on Soil Organic Carbon Stocks in Northeast China
Authors: Song Yang , Huang Shuai , Zhang Haiying , Wang Qin , Ding Lin , Liu Yanjie
Published: December 2023

Climate warming has resulted in significant changes in permafrost in Northeast China, leading to notable alterations in soil organic carbon (SOC) stocks. These changes are crucial for both the global carbon cycle and climate change, as well as directly impacting the sustainable development of ecosystems. In order to examine the SOC dynamics and the impact of permafrost changes on SOC, we investigate the changes of permafrost extent based on a regression model and TTOP (top temperature of permafrost) model and the relationship between land use and land cover (LULC), SOC stocks, and permafrost changes in Northeast China. The results showing a shrinking permafrost area from 37.43 × 104 km2 to 16.48 × 104 km2 during the period from the 1980s to the 2010s in Northeast China, and the SOC stock decreased by 24.18 Tg C from the 1980s to the 1990s and then rapidly increased by 102.84 Tg C in the 2000s. Permafrost degradation speeds up the succession of LULC, impacting about 90% of the SOC in permafrost regions. The relationship between permafrost changes and SOC in Northeast China shows that permafrost degradation significantly reduces SOC stocks in the short term but increases SOC stocks in the long term, and that LULC play a crucial role in regulating this relationship. The goals of this study are to acquire an understanding of permafrost status and deepening insights into the dynamics of SOC. Simultaneously, the study aims to furnish valuable scientific references for shaping policies on sustainable land use and management in the future, all the while advancing the cause of ecological equilibrium and sustainable development in Northeast China and other areas.
The Environmental and Genetic Controls of Increment Suggest a Limited Adaptability of Native Populations of Norway Spruce to Weather Extremes
Authors: Matisons Roberts , Katrevičs Juris , Zeltiņš Pauls , Jansone Diāna , Jansons Āris
Published: December 2023

In the Baltics, warming is expected to burden the growth of Norway spruce Picea abies, with weather anomalies/extremes having strong triggering effects, which can be mitigated by tree breeding. Within the region, breeding programmes have been aiming for productivity, yet being conservative, their sustainability depends on the adaptability of native genotypes, which is unclear. The adaptability of genotypes can be assessed through local adaptations and phenotypic plasticity, with the sensitivity of increment depicting the conformity of genotypes and environments. To assess the adaptability of native populations to anticipated climates, local genetic adaptation and phenotypic plasticity of the weather sensitivity of the radial increment were assessed by the methods of time series analysis and quantitative genetics based on three clonal trials (low-density single-tree plot plantations of grafted clones of native plus trees) representing the local climatic gradient in Latvia. The growth of trees was sensitive to the moisture availability in summer and the thermal regime in winter, yet coinciding anomalies in both were associated with abrupt changes in tree ring width. These environmental effects differed among the clones, indicating genetic controls over the sensitivity of increment, which, however, decreased under a warmer climate, suggesting a limited adaptability of local populations to warming. Still, the weather-growth relationships showed moderate phenotypic plasticity, suggesting some mid-term adaptability. Accordingly, supplementation of breeding populations via assisted gene transfer with the genotypes that are adapted to warmer and drier climates appears crucial.
Protecting Rural Large Old Trees with Multi-Scale Strategies: Integrating Spatial Analysis and the Contingent Valuation Method (CVM) for Socio-Cultural Value Assessment
Authors: Yao Na , Gu Chenxi , Qi Jinda , Shen Shigang , Nan Bo , Wang Hongjie
Published: December 2023

Governments are faced with the unique challenge of implementing large-scale and targeted protection against the global decline of large old trees. Incorporating socio-cultural values and encouraging public involvement are important parts of conservation policy. However, current studies on the socio-cultural valuation of large old trees are still limited, and how rural residents perceive the human-related value of large old trees remains largely unknown. Using a quantitative, spatial analysis and the contingent valuation method (CVM), we tried to explore a multi-scale socio-cultural valuation and protection framework based on a case study of Baoding City and Xiongan New Area in North China. The results showed that (1) the scattered large old trees in the study area were generally at a relatively younger stage, showing normal growth performance but having poor living environments. Some 96.99% of the trees resided in the countryside. Their distribution showed an agglomerative pattern with several clusters. (2) The species richness was relatively lower than that reported in urban areas. The species diversity had an obvious high–low gradient from the mountain to plain areas. Most endemic species were found in habitats of the village fringe (VF) and government/community/institutional ground (GC). (3) The mean willingness to pay (WTP) for the socio-cultural value of scattered large old trees was CNY 132.48 per year per person (1 US dollar equals about 7.2 CNY) of all the respondents, and CNY 84.30 per year per person with regard to farmers, which is relatively higher than that reported in large cities. (4) Economic income, gender, age, education level, place of residence, diameter at breast height, and tree habitat were factors that significantly influenced the WTP, among which economic income was the most significant. (5) The importance ranking of socio-cultural value connotations perceived by rural residents was as follows: spiritual attachment and homesickness > fengshui > social bond > witnessing history > education > creative inspiration. (6) The annual gross value was estimated to be CNY 349 million in the study area, and CNY 169,500 for a single tree on average. Based on the case study, a conceptual framework for socio-cultural value assessment and multi-scale protection of large old trees was proposed, which can provide references for the improvement of current conservation policies from both quantitative and qualitative perspectives, and give insights into rural revitalization strategies in China.
Integrating Knowledge Graphs into Distribution Grid Decision Support Systems
Authors: Kor Yashar , Tan Liang , Musilek Petr , Reformat Marek Z.
Published: December 2023

Distribution grids are complex networks containing multiple pieces of equipment. These components are interconnected, and each of them is described by various attributes. A knowledge graph is an interesting data format that represents pieces of information as nodes and relations between the pieces as edges. In this paper, we describe the proposed vocabulary used to build a distribution system knowledge graph. We identify the concepts used in such graphs and a set of relations to represent links between concepts. Both provide a semantically rich representation of a system. Additionally, we offer a few illustrative examples of how a distributed system knowledge graph can be utilized to gain more insight into the operations of the grid. We show a simplified analysis of how outages can influence customers based on their locations and how adding DERs can influence/change it. These demonstrative use cases show that the graph-based representation of a distribution grid allows for integrating information of different types and how such a repository can be efficiently utilized. Based on the experiments with distribution system knowledge graphs presented in this article, we postulate that graph-based representation enables a novel way of storing information about power grids and facilitates interactive methods for their visualization and analysis.
Genetic Architecture of Abdominal Fat Deposition Revealed by a Genome-Wide Association Study in the Laying Chicken
Authors: Guo Jun , Qu Liang , Shao Dan , Wang Qiang , Li Yongfeng , Dou Taocun , Wang Xingguo , Hu Yuping , Tong Haibing
Published: December 2023

Fat has a high energy density, and excessive fatness has been recognized as a problem for egg production and the welfare of chickens. The identification of a genetic polymorphism controlling fat deposition would be helpful to select against excessive fatness in the laying hen. This study aimed to estimate genomic heritability and identify the genetic architecture of abdominal fat deposition in a population of chickens from a Dongxiang blue-shelled local breed crossbred with the White Leghorn. A genome-wide association study was conducted on abdominal fat percentage, egg production and body weights using a sample of 1534 hens genotyped with a 600 K Chicken Genotyping Array. The analysis yielded a heritability estimate of 0.19 ± 0.04 for abdominal fat percentage; 0.56 ± 0.04 for body weight at 72 weeks; 0.11 ± 0.03 for egg production; and 0.24 ± 0.04 for body weight gain. The genetic correlation of abdominal fat percentage with egg production between 60 and 72 weeks of age was −0.35 ± 0.18. This implies a potential trade-off between these two traits related to the allocation of resources. Strong positive genetic correlations were found between fat deposition and weight traits. A promising locus close to COL12A1 on chromosome 3, associated with abdominal fat percent, was found in the present study. Another region located around HTR2A on chromosome 1, where allele substitution was predicted to be associated with body weight gain, accounted for 2.9% of phenotypic variance. Another region located on chromosome 1, but close to SOX5, was associated with egg production. These results may be used to influence the balanced genetic selection for laying hens.
Novel Homozygous FA2H Variant Causing the Full Spectrum of Fatty Acid Hydroxylase-Associated Neurodegeneration (SPG35)
Authors: German Alexander , Jukic Jelena , Laner Andreas , Arnold Philipp , Socher Eileen , Mennecke Angelika , Schmidt Manuel A. , Winkler Jürgen , Abicht Angela , Regensburger Martin
Published: December 2023

Fatty acid hydroxylase-associated neurodegeneration (FAHN/SPG35) is caused by pathogenic variants in FA2H and has been linked to a continuum of specific motor and non-motor neurological symptoms, leading to progressive disability. As an ultra-rare disease, its mutational spectrum has not been fully elucidated. Here, we present the prototypical workup of a novel FA2H variant, including clinical and in silico validation. An 18-year-old male patient presented with a history of childhood-onset progressive cognitive impairment, as well as progressive gait disturbance and lower extremity muscle cramps from the age of 15. Additional symptoms included exotropia, dystonia, and limb ataxia. Trio exome sequencing revealed a novel homozygous c.75C>G (p.Cys25Trp) missense variant in the FA2H gene, which was located in the cytochrome b5 heme-binding domain. Evolutionary conservation, prediction models, and structural protein modeling indicated a pathogenic loss of function. Brain imaging showed characteristic features, thus fulfilling the complete multisystem neurodegenerative phenotype of FAHN/SPG35. In summary, we here present a novel FA2H variant and provide prototypical clinical findings and structural analyses underpinning its pathogenicity.
Putting Indigenous Cultures and Indigenous Knowledges Front and Centre to Clinical Practice: Katherine Hospital Case Example
Authors: Parter Carmen , Gwynn Josephine , Wilson Shawn , Skinner John C. , Rix Elizabeth , Hartz Donna
Published: December 2023

The inclusion of Indigenous cultures, known as the cultural determinants of health, in healthcare policy and health professional education accreditation and registration requirements, is increasingly being recognised as imperative for improving the appalling health and well-being of Indigenous Australians. These inclusions are a strengths-based response to tackling the inequities in Indigenous Australians’ health relative to the general population. However, conceptualising the cultural determinants of health in healthcare practice has its contextual challenges, and gaps in implementation evidence are apparent. In this paper, we provide a case example, namely the Katherine Hospital, of how healthcare services can implement the cultural determinants of health into clinical practice. However, to be effective, health professionals must concede that Australia’s Indigenous peoples’ knowledges involving cultural ways of being, knowing and doing must co-exist with western and biomedical knowledges of health practice. We use the Katherine Hospital ABC Radio National Background Briefing interview, which was mentioned by two research participants in a 2020 study, as an example of good practice that we can learn from. Additionally, the six Aboriginal and Torres Strait Islander Health actions contained in the 2nd Edition of the Australian National Safety and Quality Health Service Standards provide governance and accountability examples of how to enable Indigenous people’s cultures and their knowledges in the provision of services. The role of non-Indigenous clinical allies and accomplices is imperative when embedding and enacting Indigenous Australians’ cultures in service systems of health. When Indigenous Peoples access mainstream hospitals, deep self-reflection by allies and accomplices is necessary to enable safe, quality care, and treatment that is culturally safe and free from racism. Doing so can increase cultural responsiveness free of racism, thereby reducing the inherent power imbalances embedded within mainstream health services.
Forest Bathing Increases Adolescents’ Mental Well-Being: A Mixed-Methods Study
Authors: Keller Jennifer , Kayira Jean , Chawla Louise , Rhoades Jason L.
Published: December 2023

Previous research has demonstrated that practicing forest bathing has significant positive effects on adult psychological well-being. Considering the ongoing adolescents’ mental health crisis of increasing anxiety and depression, determining whether forest bathing has similar effects on adolescents is an important expansion of forest bathing research. This study investigated the possibility that forest bathing could improve adolescents’ mental well-being and sought to determine participants’ experiences of forest bathing. It used a convergent, parallel, mixed-methods design that was partially co-created with 24 participants aged 16–18 as part of a youth participatory action research (YPAR) project in which participants practiced forest bathing three times over 3 weeks. As measured using the Warwick–Edinburgh Mental Well-Being Survey, the mean participant mental well-being increased significantly after forest bathing, with moderate to large effect sizes. Participants described reduced stress and increased feelings of relaxation, peace, and happiness. These findings correlate with previous forest bathing research involving adult participants. It is recommended that educators and others who work with adolescents consider forest bathing as a simple, low-cost way to improve adolescents’ mental well-being.