bluuebunny/crossref_metadata_2025 huggingface dataset:
Play Therapy Modified Ludo Games Decreasing Hyperactivity, Impulsivity, And Inattention In Children With Attention Deficit And Hiperactivity Disorder
Authors: Puspitosari Aniek
Published: August 2022

Background: Attention Deficit and Hyperactivity Disorder (ADHD) is a disorder experienced by children with characteristics including hyperactivity, impulsiveness, and inattention things that affect the occupational performance of children in their activities. Occupational therapy play a role in handling ADHD children through play therapy methods. One of the children's games that have therapeutic value is the modified ludo game. Modified ludo game can be applied to decreasing symptom ADHD. The aim of the study was to investigate the effect of modified ludo game on hyperactivity, impulsivity and inattention in children with ADHD.

Methods: Quantitative with pre-experimental research design, one group pretest-posttest with a sample size of 36 children with ADHD in RSUP Dr. Sardjito Yogjakarta. The sampling technique was purposive sampling, inclusion criteria: being able to understand simple commands, aged 3 - 6 years old, no motor impairment and able to move. The time of study was carried out in 2020-2021. Three rules modified ludo games models are provided in each session. The measuring instrument use ADHD rating scale that is valid and reliable. The data analysis method uses a paired sample t-test.

Results: Paired sample t-test results showed that p-value < 0.05. Play therapy modified ludo games intervention have a possitive and significant effect on hyperactivity, impulsivity, and inattention in children with ADHD (ρ = 0.001).

Conclusion: Play therapy modified ludo games has an effect on decreasing hyperactivity, impulsivity, and inattention in children with ADHD, so it’s recommended as an alternative game for occupational therapy for ADHD children.
Sensitivity And Specificity Numerical Range Scale-Competency (NRS-C) In Emergency Care
Authors: Suwardianto Heru , Angraini Santi
Published: August 2022

Background: Emergency conditions always occur every day around us, and the delay in aid makes the condition getting worse after arriving at the emergency department. Emergency competency assessments that continue to develop ensure increased competence for students to further increase student awareness of emergency conditions. The research objective is the development of the Emergency Sensitivity and Specificity Range Scale Competency (NRS-C) for Emergency Services

Methods: Observational analytical research method using secondary data competency assessment of 101 respondents who have done daily emergency training. Inclusion criteria, namely high school students’ class XI and XII. The sampling technique used is random sampling by taking randomly (single blink). Data were analyzed using the Receiver Operating Curve (ROC Curve).

Results: The results showed that most respondents were 16 years old (41%), and have a female gender (54%). The results showed that the sensitivity value was 84% and the specificity was 16%, with an AUC Area value of 0.794, and p=0,001, which means it has a fairly good AUC value.

Conclusion: The NRS-C instrument can be used in the emergency department competency assessment which is quite good in assessing the competence of an emergency department..
A Qualitative Study Of Emergency Nurses’ Basic Life Support Practices In A Ghanaian University Hospital
Authors: Afrifa Alex Darteh , Abdulai Mohammed Najimudeen , Prah James Kojo
Published: August 2022

ABSTRACT

Background: Medical emergencies are common but Sudden Cardiac Arrest (SCA) incidences are rare; yet when they occur could be life threatening leading either to disability or death. During SCA incidents, health care professionals will be required to act skilfully and swiftly to restart the heart and stabilise the patient until advanced care can be accessed or provided. There is evidence that victims of cardio and/or respiratory arrest whilst in the hospital will have improved outcomes if Cardiopulmonary Resuscitation (CPR) is initiated within three to five minutes. The objectives of this study were to find if emergency nurses were adequately resourced to practice Basic Life Support (BLS), and the ease or difficulties with which they practice BLS.

Methods: This Qualitative Descriptive (QD) study was conducted at the University of Cape Coast Hospital (UCCH) between June and September 2019. Six nurses were purposively recruited for the study. All interviews were audio-recorded and transcribed verbatim. The transcription was done with Microsoft Word and transferred to Microsoft Excel for thematic analysis using an inductive descriptive approach. Data analysis took a conventional qualitative content analysis approach.

Results: Four of the participants were females whilst two were males. During data aggregation and analysis, 17 first-level codes were extracted from which two themes, five categories and six subcategories were obtained for discussion. The major themes were: (1) Basic Life Support (BLS) equipment and material resources, and (2) working environment and human resource.

Conclusion: The study found that nurses working at emergency ward at UCCH were adequately resourced and well prepared to practice BLS. They however had challenges as their work seem to be hindered by patients who present to the ward without emergency needs and unavailability of emergency drugs.
Increasing Public Confidence In Accessing Public Safety Center-119 Services Through First Aid Training
Authors: Sunarto Sunarto , Harnanto Addi Mardi
Published: August 2022

Background: Emergency conditions in Indonesia can be caused by the vulnerability of disasters, accidents and diseases that threaten life or cause disability in humans. Emergency conditions require immediate assistance to prevent death and disability. The community as the first helper holds a very important key to the safety of individuals who are experiencing emergency conditions. Not all people are familiar with the PSC-119 service. The results of the preliminary study also showed that most of the respondents expressed lack of confidence because they had never received any socialization or training on how to provide first aid.

Methods: a form of experimental research with a pretest-posttest model, with intervention towards respondents related to actions in first aid training. Respondents in this study were 217 special lay people. The sampling technique in this study was random sampling by distributing invitations to special lay people in the city of Surakarta, consisting of members of the Voluntary Corps, health cadres and Linmas Kelurahan at Surakarta City. The data analysis technique used a t test

Results: There was an increase in the value between the pretest and posttest of 12.2 and the result of different test (t test) shows the value of Sig. (2-tailed) is 0.00.

Conclusion: There was an increase in community confidence in accessing PSC-119 services after first aid training was carried out for victims with significant emergency conditions.
Audio Hypno-Analgesia Intervention Effect On Pain Levels During Wound Treatment At JR Care Nursing Practice
Authors: Prasetya Hanung , Heryyanoor Heryyanoor , Febriana Annisa
Published: August 2022

Background: Wound care often causes complaints of side effects, pain, and discomfort for patients, which need to be minimized. Efforts to minimize pain and discomfort include the provision of hypnoanalgesia complementary therapy interventions with additional hypnosis audio hypnoanalgesia methods that cause a feeling of relaxation in patients during wound care. This study analyzed the effect of audio hypnoanalgesia on pain levels in wound care.

Methods: Quasi-experimental research using a random control trial was conducted at the JR Care Independent Nursing Practice, Banjarbaru from January to December 2020. The population was 120 patients with total randomization of 60 subjects from the treatment group and 60 subjects from the control group receiving standard care. The independent variable is audio hypnoanalgesia, while the dependent variable is the level of pain. Hypnoanalgesia was performed using hypnosis recordings/audio while pain level was measured using a numerical pain scale of 0 to 10. Data analysis used an independent t-test. The effect of the treatment was seen from the difference in the level of pain before and after being given treatment.

Result: Subjects experienced a significant decrease in mean pain in the treatment group from a mean of 4.95, SD = 0.67 before treatment to a mean of 0.13, SD = 0.34 after treatment, effect size 0.97 using Cohen's formula and statistically significant (p = 0.000) which means the administration of audiohypnoanalgesia has a positive effect on reducing pain levels.

Conclusion: Hypnoanalgesia audio therapy can be used to minimize patient pain during wound care.
Factors Affected Recovery Time Of Residents With Covid-19
Authors: Nuzula Firdawsyi , Oktaviana Maulida Nurfazriah
Published: August 2022

Background: The massive spread of Covid-19 and made it a pandemic causing a lot of fear and anxiety among people around the world. Covid-19 has been a global disaster which has a high level of spread and severity since it is a contagious disease. The severity of this disease ranges from asymptomatic to severe with general symptoms of fever and cough and causing acute respiratory distress syndrome, especially in the elderly and people with comorbidity. Family support helps patients to meet their basic needs and can help to increase the spirit to recover which is one of the factors that accelerate the patient’s recovery process.

Methods: Population in this study consisted 660 residents who had confirmed Covid-19 and 109 samples were taken with purposive sampling technique appropriately to inclusion criteria. Independents variables in this study consisted of history of co-morbidities, knowledge, family support  and motivation to recover. While the dependent variable is the healing time of Covid-19. The instrument of this study used a questionnaire sheet. This is a correlational study with cross sectional quantitative analytic.

Results: Bivariate analytic show that only family support variable has significant results with p value <0,05.  Family support is the determinant factors with p value of 0,0017 compared with other factors such as comorbid, knowledge  and motivation.

Conclusion: It can be conclude that family support is the determinant of recovery time of people affected by Covid-19. The most needed support for healing in the form of being sufficient and meeting the needs during ilness, both physically and psychologically.
Using An Electrical Toothache Salvadora Perisca To Increasing Oral Health Quality: A Manikin Trial
Authors: Satino Satino , Setyorini Yuyun , Darmawan Rendi Editya
Published: August 2022

Background: The most effective way of oral care in patients with decreased consciousness is not yet known. Electrical toothace salvadora perisca has the potential to improve oral hygiene because it has an antibiotic effect, and is easy to use. Aim of study is to know the effect of electrical toothace salvadora perisca on oral health quality.

Methods: A pre-experimental study in a laboratory using manikins in 2021. The study was conducted by 6 respondents in which each respondent performed 2 oral treatments using an electrical toothace salvadora perisca on the mouth of a manikin that had been dirty make-up using Ky Jelly. The toothbrush was operated for 1 minute evenly on the teeth, and foam sticks are used to clean the lips and oral mucosa. Oral hygiene was measured with a modified Beck Oral Assessment Scale (BOAS) instrument, and the scores of conditions before and after oral care were compared using the Wilcoxon test.

Results: Wilcoxon test showed a value of 0.002, which means that there was a difference in the BOAS score between before and after treatment. Electric toothbrushes clean teeth better, and foam sticks are able to clean the inside and soft of the patient's mouth.

Conclusion: Electrical toothace salvadora perisca can increasing oral health quality. The implication is need to find and try out the most effective way of doing oral care.
Hypnotherapy Can Reduce Anxiety Score In High Risk Pregnant Women
Authors: Islami Anida Izatul , Hardjanti Triana Sri
Published: August 2022

Background: A high-risk pregnancy can affect the psychological, social, and emotional conditions, feel afraid and anxiety. Excessive anxiety can trigger uterine contractions, abortion, and hypertension that can trigger the occurrence of preeclampsia. Hypnotherapy is one of the relaxation techniques that are done by opening the subconscious so that all forms of positive affirmations given by the therapist can be absorbed properly. Techniques like this can become good habits by empowering pregnant women so that they can get used to making positive affirmations.

Methods: This study uses quasy experimetal deisgn, respondents in the study were pregnant women who were at high risk based on the Poedji Rochyati scorecard and experienced anxiety based on the HARS questionnaire in July-August 2021. This intervention was given three sessions in 1 week for 40-50 minutes. This research process has been through informed consent from respondents.

Results: After three sessions of hypnotherapy each sample showed an effect. This can be seen from the total number of anxiety scores after the final therapy session is given. At the end of the session, two pregnant women experienced a category decrease to mild anxiety, namely Mrs N and Mrs Q. The other three pregnant women did not experience a category decrease but experienced a decrease in anxiety scores. However, all pregnant women in the study sample experienced a decrease in anxiety scores.

Conclusion: Hypnotherapy can be concluded that hypnotherapy can help pregnant women at high risk of reducing anxiety during the Covid-19 pandemic
Type Of Breast Pump And The Affect To Pain Scale, Milk Production, And Pumping Time In Breastfeeding Mothers
Authors: Rini Susilo , Ediyono Suryo , Sukmaningtyas Wilis , Hikmanti Arlyana , Kusuma Ikhwan Yuda
Published: August 2022

Background: As we know that breastfeeding saves children under five lives every year, especially during the Covid-19 pandemic. The facts show that only 43% of infants 0-6 months are exclusively breastfed. The limited time for breast milk expression in between the mother's work routine needs to be supported by an efficient and effective pump. This study aimed to assess the type of breast pump not affect to pain scale, milk production, and pumping time in breastfeeding mothers.

Methods: This research is a cross-sectional study with a sample of 36 breastfeeding mothers in Banyumas Regency. They were chosen by distributing survey invitations through the WhatsApp group with a background breastfeeding mothers. Data was collected using the Google form, and analyzed using the Chi Square statistical test with a significance level of 95% (Alpha 0.05).

Results: Chi-Square analysis test shows the Asymp value. Sig. (2-sided) for the relationship between the type of Breast Pump and the Pain Scale, the volume of breast milk expressed, and the duration of pumping are 0.001; 0.905; 0.620, so only pain scale which less than α >0,05, the others are more than α >0,05. This result means any correlation between the type of breast pump with pain scale but no correlation with the amount of milk expressed, and the time spent pumping.

Conclusion: There is no relationship between the type of breast pump, the amount of milk expressed, and  the time spent pumping, but any correlation between pain scale. So breastfeeding mothers can choose any breast pump that fits their needs and consider other factors influencing breastfeeding success.
Adolescent Sexual Behavior In The Era Of The Industrial Revolution 4.0
Authors: Prastika Dewi Andang , Hasanah Intan Nugraheni
Published: August 2022

Background: The index of adolescent knowledge about reproductive health has increased. Ease of accessing information is an important point in increasing adolescent knowledge about reproductive health, but the use of social media without parental supervision can also lead to risky sexual behavior. In this study, the author aims to determine adolescent knowledge about reproductive health, access to social media as a source of information, and sexual behavior in adolescents in Klaten.

Methods: The design in this study is a cross-sectional qualitative research. The population is adolescents aged 16-18 years in the Klaten Regency area. The sample in this study were 96 samples years by using non-probability method sampling count by lemeshow formula selected based on the inclusion and exclusion criteria through youth organizations. The instrument used was questionnaire consist of 4 indicators (usage of social media, source of health reproduction information, knowledge of health reproduction, sex behavior. After validity and reliability test, the questionnaire obtained 30 questions. Data  was collected online by using google forms. Analysis data procedure was using chi square and logistic regressionanalysis techniques.

Results: The most respondents aged 18 years (48.60%), female gender (88.78%), accessed social media for 7-12 hours as much as 57.01%, all respondents accessed search engines and whatsapp, the majority of respondents received Information about reproductive health from the internet is 90.65%, 59.81% of respondents' parents have a role in discussing reproductive health, 83.18% of respondents have good knowledge about reproductive health, 85.98 % respondents have risky sexual behavior.

Conclusion: The role of parents and the duration of adolescents accessing social media has a significant relationship in adolescent sexual behavior.
Si Embul: Assesment In Baby And Children To Increasing Haemoglobin Level In 6-24 Months Children
Authors: Purnamaningrum Yuliasti Eka , Latief Abdul , Wijayanti Setyo Rini , Lakshita Dea Surya
Published: August 2022

Background: Iron deficiency anemia is one of the health problems in Indonesian children that need special attention because it has an impact not only for now but also on the upcoming time. The si Embul innovation program is a comprehensive activity that includes growth and development checks, evaluation of exclusive breastfeeding, identification of anemia by checking the baby’s hemoglobin, and consultations with nutritionists and doctors.

Methods: This research used descriptive correlational with a cross-sectional research design. The sample was all children aged 6-24 months who are included in the Si Embul Program at the Tegalrejo Health Center in 2017-2019 as much as 149 children. The univariate analysis describes the characteristics of the research subjects. Relationship between the Si Embul Program and anemia status analyze using bivariate analysis, carried out with chi-square at a significant level of 5%. The research was carried out using secondary data in patient medical record and register books and taken from both books.

Results: The incidence of anemia was more common in female respondents as many as 31 people (20.81%). Based on the baby's birth weight, the incidence of anemia was more common in BBLN (normal birth weight) as many as 50 people (33.55%). The Si Embul program was associated with anemia status in children aged 6-24 months with a p-value of 0.004 (p<0.05).

Conclusion: The si Embul program was associated with anemia status in children aged 6-24 months with a p-value of 0.004. This shows that the excistence of Si embul program can reduce the incidence of anemia in children aged 6-24 months.
Die Entwicklung der Schadstoffbelastung von Kindern in NRW: Human-Biomonitoring-Daten aus einem Kita-Projekt/The development of pollutant exposure in children in North Rhine-Westphalia: human biomonitoring data from a day-care center project
Authors: Chovolou Yvonni , Sievering Silvia , Engelmann Jennifer , Köllner Barbara , Kraft Martin
Published: August 2022

Seit 2011 untersucht Nordrhein-Westfalen (NRW) alle drei Jahre die Schadstoffbelastung von Kindern im Alter von zwei bis sechs Jahren. Human-Biomonitoring-Daten, die zwischen 2011 und 2017 in bisher drei Querschnitten erhoben wurden, liefern wichtige Informationen über die Belastung von Kindern mit Schadstoffen. Insgesamt wurden im Urin der Kinder 23 Biomarker identifiziert, die in mindestens zwei Querschnitten eine Detektionsrate von über 50 % hatten. Für acht dieser Biomarker wurde im betrachteten Untersuchungszeitraum eine statistisch signifikante Abnahme der Belastung gefunden. Dazu gehören aus der Gruppe der Phthalate die Metaboliten Mono-n-Butylphthalat (MnBP), Mono- Benzylphthalat (MBzP), Mono-(2-Ethylhexyl)Phthalat (MEHP) und 7oxo-Mono-Methyloctylphthalat (oxoMINP), bei den Konservierungsmitteln Methylparaben (MeP), Ethylparaben (EtP) und nPropylparaben (nPrP) sowie Glyphosat (GLY) aus der Gruppe der Herbizide. Für drei Biomarker wurde eine signi- fikante Zunahme der Belastung gefunden. Dazu gehören Cyclohexan-1,2-Dicarbonsäure-Mono-Hydroxyisononylester (MINCH) aus der Gruppe der Weichmacher, n-Methylmalonamsäure (NMMA) aus der Gruppe der Konservierungsmittel und 3-Phenoxybenzoesäure (3-PBA) aus der Gruppe der Insektizide. Insgesamt zeigen die Ergebnisse, dass die Belastung der Kinder mit zahlreichen kritischen Substanzen, insbesondere Phthalaten und Parabenen, rückläufig ist. Für einige andere nimmt die Belastung jedoch zu, sodass die fortgesetzte Erhebung von Human-Biomonitoring-Daten notwendig ist, um die Entwicklung der Exposition auch zukünftig zu erfassen.
Berufskrankheiten durch arbeitsbedingte Einwirkungen polyzyklischer aromatischer Kohlenwasserstoffe – BK-Report 1/2022 „Ermittlung der Benzo[a]pyren-Dosis (BaP-Jahre)“/Occupational diseases caused by work- place exposure to polycyclic aromatic hydrocarbons – OD Report 1/2022: “Determination of Benzo(a)pyrene Exposure in BaP Years“
Authors: Teich Elfi , Heinrich Birgit
Published: August 2022

In einem Berufskrankheiten- Report (BK-Report) werden qualitative und quantitative Einwirkungen dargestellt, um einerseits die Arbeitsanamnese in Ermittlungsverfahren zu erleichtern und andererseits eine einheitliche Beurteilung von Expositionen zu gewährleisten. Bei Krebserkrankungen durch chemische Einwirkungen oder Stäube, wie aromatische Amine und Quarz, bei denen nach aktuellem Kenntnisstand keine anerkannten Dosis-Wirkungsmodelle existieren, ist eine Quantifizierung nur in Einzelfällen möglich. Für die Einwirkung durch polyzyklische aromatische Kohlenwasserstoffe (PAK) kommt dagegen für die inhalative Exposition das Dosis-Wirkungsmodell zum Einsatz. Liegt eine ausschließlich dermale Belastung vor, kann diese allerdings nur qualitativ beschrieben werden. Der BK-Report zur Erstellung einer qualifizierten Anamnese bei PAK-Expositionen an Arbeitsplätzen wurde unter anderem überarbeitet, um eine Bewertung der neu hinzugekommenen Berufskrankheiten Schleimhautveränderungen, Krebs oder andere Neubildungen der Harnwege sowie Kehlkopfkrebs vornehmen zu können. Des Weiteren wurde der Report aktualisiert, um Expositionsdaten zu weiteren branchenspezifischen Arbeitsbereichen und Tätigkeiten erweitert und um statistische Daten ergänzt.
Betrachtungen zur Anwendung von Niederschlagsdaten in der Ausbreitungsrechnung/Considerations for the Application of Precipitation Data for Dispersion Modeling
Authors: Petrich Ralf , Delan Axel
Published: August 2022

Nach Inkrafttreten der Technischen Anleitung zur Reinhaltung der Luft (TA Luft) 2021 wird die Verwendung von Niederschlagsdaten des Umweltbundesamtes (UBA) für Ausbreitungsrechnungen bestimmter Gase obligatorisch, was bestimmte Konsequenzen nach sich zieht, die in diesem Artikel erörtert werden. Der begrenzte Zeitraum der Verfügbarkeit der Niederschlagsdaten von 2006 bis 2015 bringt Konflikte mit Regelungen der Richtlinie VDI 3783 Blatt 20 mit sich, was dazu führt, dass bei Beachtung aller Regelungen eine Reihe von Messstationen nicht mehr für eine Übertragung im Sinne dieser Richtlinie zur Verfügung steht und die ohnehin knappe Datenbasis an übertragbaren Stationen weiter verarmt. Zudem führt der begrenzte Zeitraum der Verfügbarkeit dazu, dass bei der Auswahl von repräsentativen Jahren derzeit keine Zeiträume nach 2015 mehr gefunden werden können. Die Tatsache, dass die stundenfein aufgelösten und standortspezifischen Niederschlagsdaten des UBA bei der Anwendung in der Ausbreitungsrechnung einen zeitlichen Versatz zu den von einer Station übertragenen Messwerten für Wind und Stabilität haben können, stellt eine systematische Fehlerquelle bei der Bestimmung der nassen Deposition dar. Eine Betrachtung von Positionen entlang einer Schnittlinie zwischen zwei Messstationen hat gezeigt, dass die standortspezifischen Niederschlagsdaten das unterliegende Geländeprofil plausibel abbilden, d. h., die räumliche Repräsentativität der Niederschlags- daten des UBA ist gegeben.
Roadmap on Carcinogens 2.0: EU-Initiative zur Bekämpfung von Krebs am Arbeitsplatz/Roadmap on Carcinogens (RoC) 2.0: EU-Initiative to fight occupational cancer
Authors: Clever Michaela , Kuhlbusch Thomas A. J. , Pipke Rüdiger
Published: August 2022

Mit 52 % sind Krebserkrankungen die häufigste Ursache arbeitsbedingter Todesfälle in der Europäischen Union (EU). Diese statistische Zahl allein bildet nicht annähernd die Bedeutung und Folgen für die Betroffenen und die Gesellschaft ab. Ebenso wenig beantwortet sie Fragen nach den Ursachen und Möglichkeiten der Prävention. Verschiedene europäische Interessenvertreter haben erkannt, dass gemeinsames Handeln im Kampf gegen berufsbedingte Krebserkrankungen notwendig ist und die europäische Initiative Roadmap on Carcinogens (RoC) ins Leben gerufen. Die RoC sammelt Informationen, erarbeitet Strategien und etabliert Netz- werke für den Austausch und Wissenstransfer zwischen verschiedenen Interessenvertretern im Arbeitsschutz, wie Arbeitgebenden und Beschäftigten sowie nationalen und europäischen Institutionen und Behörden. Die RoC bietet darüber hinaus ein Angebot von Informationen an, um insbesondere kleine und mittlere Unternehmen bei der Einhaltung von rechtlichen Vorgaben zu unterstützen.
Arqueología regional en la provincia de San Luis: el caso de La Travesía
Authors: Heider Guillermo
Published: August 2022

En este trabajo se presentan los primeros resultados de las investigaciones de campo y laboratorio realizados en el oeste de San Luis, en la región conocida como La Travesía. Biogeográficamente presenta condiciones propias de ambientes semiárido a árido, carente de agua en superficie apta para los requerimientos fisiológicos de los grupos humanos. Arqueológicamente no se verifican trabajos recientes por fuera de nuestro proyecto, con lo cual, en primera instancia se presenta una revisión de la bibliografía arqueológica del siglo pasado. En un segundo momento se detallan los trabajos desarrollados, incluyendo una caracterización inicial de los sitios reconocidos a partir de su ubicación en las unidades geomorfológicas locales y las materias primas identificadas. A partir de la síntesis de investigaciones pretéritas y de la nueva información generada se discute una primera tendencia espacial, y en menor medida cronológica, de las ocupaciones indígenas. Los elementos del paisaje capaz de contener agua y los afloramientos de rocas aptas para la talla son, hasta el momento, los puntos del espacio que concentran las evidencias de ocupación humana. Esto es coherente con lo esperado para espacios con déficit hídrico notorio, donde el agua y las rocas fueron recursos críticos para tomar decisiones.
Molecular diversity of the base-promoted reaction of phenacylmalononitriles with dialkyl but-2-ynedioates
Authors: Zheng Hui , Han Ying , Sun Jing , Yan Chao-Guo
Published: August 2022

In the presence of tetrabutylammonium bromide (TBAB), the cycloaddition reaction of phenacylmalononitriles with dialkyl but-2-ynedioates in acetonitrile at room temperature resulted in 3,3-dicyano-5-hydroxy-5-arylcyclopent-1-ene-1,2-dicarboxylates in high yields. More importantly, the DABCO-promoted domino reaction of two molecules of each phenacylmalononitrile and dialkyl but-2-ynedioate in acetonitrile at room temperature afforded unique multifunctionalized carboxamide-bridged dicyclopentenes in moderate to good yields and with high diastereoselectivity.
Endocytosis and transport of silica nanoparticles in BeWo b30 cells
Authors: Tang Hongbo , Jiang Weijie , Feng Xin , Chen Yetao , He Junyu , Wu Mengyao , Yin Chenghong , He Haibo
Published: August 2022

An understanding of the transport of silica nanoparticles (NPs) across the placental barrier is important in perinatal medicine. The cytotoxicity of silica NPs was investigated in this study. In uptake assays, we examined the size of NPs, as well as the effects of various inhibitors, on the internalization of silica NPs in BeWo b30 cells. The levels of PI3K, AKT, and GSK3β were assessed after the cells were treated with silica NPs and/or the PI3K/AKT signaling pathway inhibitor LY294002. The integrity of the cell monolayer was assessed by culturing cells on Transwell inserts and measuring the transepithelial electrical resistance, assessing fluorescein sodium transport, and staining the tight junction protein zonula occludens-1. Silica NPs were spherical in shape, and concentrations <300 μg/mL were not cytotoxic. The internalization of silica NPs with a diameter of 50 nm was greater than that of silica NPs with a diameter of 20 nm. CPZ showed the most pronounced inhibitory effects, with inhibition rates of 20-nm, 50-nm, and 100-nm silica NPs reaching 57.5%, 49.6%, and 46.9%, respectively, indicating that silica NPs were internalized through clathrin- and caveolae-mediated endocytosis. Furthermore, LY294002 affected the uptake of 50-nm silica NPs dose-dependently. The treatment of cells with silica NPs also increased the levels of P-PI3K/PI3K, P-AKT/AKT, and P-GSK3β/GSK3β, while LY294002 inhibited the levels of these proteins, indicating that the internalization of silica NPs is regulated by the PI3K/AKT/GSK3β signaling pathway. Taken collectively, these results provide new insights on the transplacental transport of NPs in perinatal medicine.
Is Buprenorphine More Effective and Safer Than Other Medical Treatments for Managing Opioid Withdrawal? A Cochrane Review Summary With Commentary
Authors: Wallace Ina F. , Viswanathan Meera
Published: August 2022

This paper summarizes the published Cochrane Review, “Buprenorphine for Managing Opioid Withdrawal,” by L. Gowing, R. Ali, J. M. White, & D. Mbewe (https://doi.org/10.1002/14651858.CD002025.pub5), and discusses it through a treatment policy and practice lens.
Identification of Antioxidants Activity and Phytochemical Compounds of Coffee Powder Robusta (Coffea Canephora), Robusta Lanang (Peaberry Coffee) And Arabica (Coffea Arabica), In Umkm Kopi Kare, Madiun Regency
Authors: Suleman Dininurilmi Putri , Ramadhan Abdi Yenny Febriana , Mukti Sari Mulyani , Darisna Lufi Ayunda , Agustin Leony Putri , Pamungkas Niken Ayu Putri , Sari Resti Oktavia , Febriana Rizki Pradani
Published: August 2022

Coffee is one of the plantation commodities in Indonesia which acts as a source of foreign exchange and is a source of income for one and a half coffee farmers. One of the regions in Indonesia possessing abundant coffee resources is Madiun Regency especially Kare Village. UMKM Kopi Kare produces three types of coffee products, specifically robusta, robusta lanang, and arabica. In order to determine the characteristics of the 3 coffee variants produced by UMKM Kopi Kare, an analysis of antioxidants and phytochemical compounds were carried out. Antioxindant activity was analyzed using DPPH method and phytochemical compounds were analyzed using qualitative method. Based on the antioxidant test results, robusta 83.41 ± 2.64%, robusta lanang 84.71 ± 3.45%, and arabica 84.32 ± 2.66%. The results of the phytochemical test showed that the three variants of UMKM Kopi Kare contained phytochemical compounds including flavonoids, saponins, tannins, and alkaloids.
REVIEW: PENGGUNAAN MATRIKS PADA SISTEM PELEPASAN EXTENDED RELEASE SEDIAAN TABLET METFORMIN HCL
Authors: Agus Andrie Agus , Anis Yohana Chaerunisa
Published: August 2022

Terapi farmakologi lini pertama pada pasien diabetes melitus terutama diabetes melitus tipe II pada pasien obesitas dan yang memiliki fungsi ginjal normal adalah metformin. Namun, metformin dengan sistem pelepasan segera ditemukan memiliki banyak kelemahan seperti menimbulkan efek samping dan rendahnya kepatuhan pasien. Untuk mengatasi hal tersebut, maka dikembangkan formulasi dengan pelepasan diperpanjang (extended release). Tujuan penulisan review artikel ini adalah memberikan informasi dan gambaran mengenai matriks yang dapat digunakan untuk formulasi tablet metfomin HCl dengan sistem pelepasan extended release khususnya sistem controlled release dan sustained release. Review artikel ini menggunakan metode penelitian komparatif dari 21 jurnal penelitian dengan jurnal bahasa inggris dan indonesia yang membahas formulasi sediaan tablet metformin HCl dengan pelepasan extended release (sustained release dan controlled release), dengan rentang tahun 2012 hingga 2022. Dapat disimpulkan bahwa hasil review mengindikasikan metformin HCl dapat dibuat dalam bentuk tablet matriks dengan sistem pelepasan extended release dengan menggunakan matriks guar gum dan polivinil pirolidon K30, poli magnesium akrilat, eudragit RS 30D, natrium alginate, dan kitosan.
Sexism issues in the Tears of the Giraffe by Alexander McCall Smith
Authors: Zamil Hussein Kadhim
Published: August 2022

The findings of this study are likely to add to the growing body of literature-related research, particularly on the topic of liberal sexism in literary works. Using liberal feminist literary studies, this work employs a literary strategy based on literary criticism. The book Tears of the Giraffe by Alexander McCall Smith, published by Abascus, is the subject of this study. The book Tears of the Giraffe serves as the major data source for this investigation. In 2006, this book was released with 398 pages of content. Reading, listening, and taking notes were the primary methods of gathering data for this investigation. A qualitative descriptive method was used to analyze the data. The novel's characters, locations, and themes were used to identify sexims issues in the novel's content. It may be seen in the novel's characters that women degrade other female characters in terms of sexism. Male characters don't denigrate the female character as much as they might. It may discern the shape of the sexism dilemma by looking for statements or quotations that suggest it. According to Alexander McCall Smith's book Tears of the Giraffe, women have sexism issues. For both family and business, Alexander McCall Smith portrayed in Tears of the Giraffe.
Analysis of the Utilization of Capitation Funds for the National Health Insurance Program at the Kute Panang Health Center
Authors: Nuh Muhammad , Nyorong Mappeaty , Nadapdap Thomson P.
Published: August 2022

The research objective is to analyze the utilization of capitation funds, utilization of services and utilization of operational costs of health services for the National Health Insurance program at the Kute Panang Health Center. Research uses are theoretical/scientific and practical uses. The type and design of the research used was descriptive qualitative. The data sources used are primary data and secondary data. Data collection techniques through interviews, observation and documentation. Data analysis techniques through data collection, data reduction, data presentation, conclusion drawing and clarification. data validity test is done through Triangulation and Member Check. the research stage consists of the pre-field stage, the field work stage, and the data analysis stage. 21 of 2016. and Decree of the District Head of Central Aceh No. 425/ Dinkes/2019 concerning the use of JKN capitation funds at Puskesmas. Analysis of utilization of health services (health workers and non-health workers) by 70%. Analysis of the Utilization of Health Service Operational Costs for activities inside the building, outside the building by 30%. 21 of 2016 and the Decree of the District Head of Central Aceh No. 425/ Dinkes/2019 as technical guidelines and regional policies in the use of JKN capitation funds at the Community Health Center. The utilization of capitation funds is 70% for payment of health services and 30% for other health operations.
Line-by-line Velocity Measurements: an Outlier-resistant Method for Precision Velocimetry
Authors: Artigau Étienne , Cadieux Charles , Cook Neil J. , Doyon René , Vandal Thomas , Donati Jean-François , Moutou Claire , Delfosse Xavier , Fouqué Pascal , Martioli Eder , Bouchy François , Parsons Jasmine , Carmona Andres , Dumusque Xavier , Astudillo-Defru Nicola , Bonfils Xavier , Mignon Lucille
Published: August 2022

We present a new algorithm for precision radial velocity (pRV) measurements, a line-by-line (LBL) approach designed to handle outlying spectral information in a simple but efficient manner. The effectiveness of the LBL method is demonstrated on two data sets, one obtained with SPIRou on Barnard’s star, and the other with the High Accuracy Radial velocity Planet Searcher (HARPS) on Proxima Centauri. In the near-infrared, the LBL provides a framework for meters-per-second-level accuracy in pRV measurements despite the challenges associated with telluric absorption and sky emission lines. We confirm with SPIRou measurements spanning 2.7 yr that the candidate super-Earth on a 233 day orbit around Barnard’s star is an artifact due to a combination of time sampling and activity. The LBL analysis of the Proxima Centauri HARPS post-upgrade data alone easily recovers the Proxima b signal and also provides a 2σ detection of the recently confirmed 5 day Proxima d planet, but argues against the presence of the candidate Proxima c with a period of 1900 days. We provide evidence that the Proxima c signal is associated with small, unaccounted systematic effects affecting the HARPS-TERRA template-matching radial velocity extraction method for long-period signals. Finally, the LBL framework provides a very effective activity indicator, akin to the FWHM derived from the cross-correlation function, from which we infer a rotation period of

92.1

−
3.5

+
4.2

days for Proxima.
Gamma-Ray Burst Constraints on Cosmological Models from the Improved Amati Correlation
Authors: Liu Yang , Liang Nan , Xie Xiaoyao , Yuan Zunli , Yu Hongwei , Wu Puxun
Published: August 2022

An improved Amati correlation was constructed in ApJ 931 (2022) 50 by us recently. In this paper, we further study constraints on the ΛCDM and wCDM models from the gamma-ray bursts (GRBs) standardized with the standard and improved Amati correlations, respectively. By using the Pantheon Type Ia supernova sample to calibrate the latest A220 GRB data set, the GRB Hubble diagram is obtained model-independently. We find that at the high-redshift region (z > 1.4) the GRB distance modulus from the improved Amati correlation is larger apparently than that from the standard Amati one. The GRB data from the standard Amati correlation only give a lower bound limit on the present matter density parameter Ωm0, while the GRBs from the improved Amati correlation constrain the Ωm0 with the 68% confidence level to be

0.308

−
0.230

+
0.066

and

0.307

−
0.290

+
0.057

in the ΛCDM and wCDM models, respectively, which are very consistent with those given by other current popular observational data including baryon acoustic oscillation, cosmic microwave background (CMB) radiation, and so on. Once the H(z) data are added in our analysis, the constraint on the Hubble constant H
0 can be achieved. We find that two different correlations provide slightly different H
0 results but the marginalized mean values seem to be close to that from the Planck 2018 CMB radiation observations.
Multiwavelength Search for the Origin of IceCube's Neutrinos
Authors: Kun Emma , Bartos Imre , Becker Tjus Julia , Biermann Peter L. , Franckowiak Anna , Halzen Francis
Published: August 2022

The origin of astrophysical high-energy neutrinos detected by the IceCube Neutrino Observatory remains a mystery to be solved. In this paper we search for neutrino source candidates within the 90% containment area of 70 track-type neutrino events recorded by the IceCube Neutrino Observatory. By employing the Fermi-LAT 4FGL-DR2, the Swift-XRT 2SXPS, and the CRATES catalogs, we identify possible gamma-ray, X-ray, and flat-spectrum radio candidate sources of track-type neutrinos. We find that based on the brightness of sources and their spatial correlation with the track-type IceCube neutrinos, the constructed neutrino samples represent special populations of sources taken from the full Fermi-LAT 4FGL-DR2/Swift-XRT 2SXPS/CRATES catalogs with similar significance (2.1σ, 1.2σ, 2σ at 4.8 GHz, 2.1σ at 8.4 GHz, respectively, assuming 50% astrophysical signalness). After collecting redshifts and deriving subsamples of the CRATES catalog complete in the redshift–luminosity plane, we find that the 4.8 GHz (8.4 GHz) subsample can explain between 4% and 53% (3% and 42%) of the neutrinos (90% C.L.), when the probability of detecting a neutrino is proportional to the (k-corrected) radio flux. The overfluctuations indicate that a part of the sample is likely to contribute and that more sophisticated schemes in the source catalog selection are necessary to identify the neutrino sources at the 5σ level. Our selection serves as a starting point to further select the correct sources.
An unusual specimen of the enigmatic fungal reproductive unit Windipila spinifera from the Lower Devonian Rhynie cherts of Scotland
Authors: Krings Michael
Published: August 2022

Windipila spinifera from the Rhynie cherts is a spheroidal microfossil enveloped in a hyphal mantle from which extend prominent spines and otherwise shaped projections. It is believed to be a reproductive unit of a fungus in the Glomeromycota or zygomycetes, but features to determine the systematic affinities have not hitherto been documented. This study describes a new specimen of W. spinifera that contains a single spherical structure from which a hypha arises that extends outside and terminates in what appears to be a sporangium. The specimen is reminiscent of germinated zygospores of the germ-sporangial type, and thus may suggest affinities of W. spinifera to the zygomycetes. However, the interior sphere and its outgrowth could also be a part of another organism that had invaded W. spinifera.
Publier, éditer, éditorialiser
Authors: Chartron Ghislaine
Published: August 2022

L’internet a installé une transformation profonde des modèles d’édition et de publication des contenus inscrits, jusqu’alors, dans des filières bien identifiées : la presse, la littérature, la musique, l’édition de jeunesse, l’édition de recherche… Le numérique a brouillé les frontières, déstabilisé les modèles en place, transformé en partie les pratiques des usagers. De multiples projets innovants ont émergé, plus ou moins plébiscités, plus ou moins pérennes notamment par leur modèle économique, une fois passé le temps des subventions. Dans un premier temps nous rappelons les caractéristiques majeures du contexte au sein duquel évoluent ces offres : économie de l’internet, évolutivité des technologies associées et des pratiques socio-numériques. De façon transversale, nous identifierons de nouvelles propositions de valeurs liées au numérique. Nous nous intéresserons aux modalités de remontées des recettes, à leur hybridation, ainsi qu’à la stratégie déployée par les géants du web dans ce secteur et, conjointement, au renouvellement des régulations. Enfin, au regard de la comparaison transversale engagée, la contribution s’attachera à proposer une typologie revisitée des modèles de publication.
Publier, éditer, éditorialiser
Authors: Romary Laurent
Published: August 2022

Le paysage actuel de la communication scientifique est en pleine tension, entre d’une part une communauté scientifique qui aspire à des mécanismes plus fluides et moins coûteux de diffusion des résultats de recherche et d’autre part, un tissu privé d’édition scientifique qui vise à préserver au maximum un chiffre d’affaires construit à partir de modèles d’un autre âge. Nous essayerons dans ce cadre d’identifier différents éléments qui permettraient de concevoir des environnements de diffusion de l’information scientifique plus adaptés aux possibilités techniques actuelles, mais aussi aux capacités financières et éditoriales de la recherche publique. De façon très pragmatique, nous repérerons des pistes d’évolution liées aux infrastructures techniques, aux licences, à la relecture par les pairs ou à la diffusion de données, en partant de l’expérience acquise au sein d’Inria depuis plusieurs années, mais nous essayerons aussi d’esquisser une vision intégrée qui puisse fournir une base cohérente pour les actions à mener à l’avenir.
Publier, éditer, éditorialiser
Authors: Kayser-Bril Nicolas
Published: August 2022

Le terme de datajournalisme a émergé à la fin des années 2000. Certains médias ont mis en place des équipes de datajournalisme, des agences spécialisées se sont créées, comme celle que j’ai cofondée en 2011, Journalism++. De nombreuses écoles de journalisme offrent des cours de datajournalisme, des conférences spécialisées ont lieu tous les ans. Si le concept a montré qu’il était plus qu’un buzzword ou qu’une mode, il reste mal défini. Certains y voient une mythologie du chiffre 1 . D’autres affirment que le datajournalisme consiste à s’adresser à l’intelligence visuelle de son audience 2 . Ces raccourcis passent à côté de l’essentiel. Faire du datajournalisme, c’est informer avec des données structurées, c’est l’utilisation de techniques statistiques, de visualisations et d’interactivité pour analyser et communiquer des données 3 . Cet essai explique ce que le concept de datajournalisme recouvre, comment il est apparu et comment il influence le quotidien des rédactions. Surtout, il montre comment le datajournalisme s’intègre dans les processus d’information préexistants et l’impact social de cette manière d’informer.
Publier, éditer, éditorialiser
Authors: Maurel Lionel
Published: August 2022

En 2006 avec la loi DADVSI 1 , la législation française sur le droit d’auteur a connu sa première tentative d’adaptation aux nouvelles réalités introduites par le numérique. Dix ans plus tard, de nombreux textes se sont succédé en la matière, qui ont sensiblement modifié les normes en vigueur. Cependant en dépit de cet empilement de nouvelles réglementations, on est frappé de constater que le droit applicable à l’acte de publication est resté globalement articulé autour des mêmes notions fondamentales. L’auteur, l’œuvre et l’éditeur demeurent les trois piliers sur lesquels l’édifice juridique continue à s’ériger, alors même que ces concepts ont à présent plus de deux cents ans.