bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors associated with unfavorable outcome of anterior circulation ischemic stroke following emergency endovascular therapy after complete recanalization
Authors: Yang Chunchao , Rissardo Jamir Pitton , Caprara Ana Letícia Fornari , Neupane Durga , Chen Yueming , Li Chandi , Li Zhenzhang , Gao Junjie , Tang Longchong , Yu Qingwen , Liang Yuhang
Published: October 2024

Objective: Endovascular thrombectomy (EVT) improves long-term patients outcomes and decreases mortality among ischemic stroke patients. However, not all patients can benefit from EVT recanalization. The present study aims to evaluate the predictors of unfavorable outcomes associated with emergency endovascular therapy despite complete recanalization.
Methods: We investigated 74 eligible patients receiving EVT from January 2019 to January 2022 at a comprehensive stroke center. Demographics, clinical, radiological and treatment characteristics, safety, and functional outcomes were collected. Modified Rankin scale (mRS) score ≤ 2 at 90 days was defined as a good functional outcome.
Results: A total of 111 patients were initially eligible for the study, of which 37 were excluded, resulting in 74 patients in the final study. The mean age was 69.08±12.12 years old, 67.57% patients were male, 44.59% patients with atrial fibrillation, 64.86% with hypertension, 21.62% patients with diabetes mellitus, 16.22% patients with coronary artery diseases, 6.76% with parenchymal hematoma. Median pre-EVT NIHSS (IQR) was 15.5 (12.0, 19.25). Median door-to-recanalization time (DRT) (IQR) was 208.0 (160.0,278.5) minutes and median last known norma to puncture time (LKNPT) (IQR), was 362.0 (280, 452.5) minutes. Individuals with a poorer outcome were older [73.56±9.29 vs. 65.28±13.02 years old, P=0.002], had a higher prevalence of atrial fibrillation (AF) [58.82 vs. 13%, P=0.023] and a higher National Institute of Health Stroke Scale (NIHSS) [median 16 (IQR 12.0-22.3) vs median 15 (IQR 10.0-18.0), P=0.143]. Female sex, hypertension, diabetes mellitus, coronary artery disease, and a slightly longer door-to-recanalization time were more prevalent in the unfavorable prognosis group; however, statistical analysis did not show any significant differences. Logistics binary regression model showed that older age [OR: 0.1.160 (1.011 to 1.112, P=0.031)] and AF [OR: 3.190 (1.111 to 9.164, P=0.031)] were associated with an unfavorable outcome.
Conclusion: Older age, and atrial fibrillation were factors associated with the unfavorable outcome despite complete recanalization after emergency EVT of ischemic stroke.
Ultrasound-guided pulsed radiofrequency of the greater occipital nerve in chronic migraine; proximal approach versus distal approach, a single-blind, randomized controlled trial
Authors: Genç Perdecioğlu Gevher Rabia , Yıldız Gökhan , Can Ezgi , Yürük Damla , Akkaya Taylan
Published: October 2024

Background & Objective: Ultrasound-guided pulsed radiofrequency treatment of the greater occipital nerve can be used at distal and proximal levels of the greater occipital nerve in patients with chronic migraine. We aimed to evaluate the treatment efficacy, procedure duration, and pain experienced during the procedure for both methods.
Methods: In the study, 60 chronic migraine patients randomly divided into two groups using a computer programme were evaluated. In the proximal group, the greater occipital nerve was accessed at the level of the 2nd cervical vertebra, while in the distal group it was accessed at the level of the protuberencia occipitalis. Patients completed the Migraine Disability Rating Scale, Visual Analogue Scale and a headache diary before treatment as well as at 1 month and 3 months afterwards. The time from the beginning of the intervention to the spread of the stimulus to the C2 dermatome during the sensory stimulation test was recorded. Patients were asked to rate their pain during the procedure using a Visual Analogue Scale.
Results: The Visual Analog Scale scores and headache frequencies were significantly decreased in both the proximal group and distal group (p<0.001). The procedure time was shorter (p<0.001) and was less painful in the distal group (p<0.001).
Conclusions: In this study, we observed that pulsed radiofrequency of both distal and proximal levels of the greater occipital nerves effectively treated migraine. A shorter procedure time and superior patient tolerability make the distal stimulation the procedure of choice.
Triglyceride-HDL index as a predictor of post-stroke outcomes: A retrospective analysis of 6,235 ischemic stroke patients from the Qatar Stroke Database
Authors: Ali Aizaz , Obaid Omar , Akhtar Naveed , Jumaa Mouhammad , Shuaib Ashfaq
Published: October 2024

Objectives: In this study, we explored the Qatar stroke database to study the independent effect of sex- specific TG-HDL index on neurologic and cardiovascular outcomes following stroke in a predominantly Arab and Southeast Asian population.
Methods: All patients admitted with acute ischemic stroke between 2014-2022 were included. TG-HDL index on admission was calculated and patients were stratified into sex-specific quartiles. We studied the 90-day modified Rankin Score (mRS), and 1-year major cardiac adverse events (MACE). Multivariate linear and binary logistic regression analyses were performed to identify the independent effect of TG-HDL index on short- and long-term outcomes.
Results: A total of 6,235 stroke patients were identified. Overall, mean age was 55±13 years; 5,122 patients (82%) male; 1,989(32%) Arab; 1,628(26%) BMI ≥30; 3,526 (57%) diabetes mellitus; 4,598 (74%) hypertension, 3,158 (51%) dyslipidemia, and 1,876 (30%) smokers. The median TG levels were 1.5 (1.0-2.3), HDL levels 1.0 (0.8-1.2), and TG-HDL index was 1.5 (1.0-2.3). On long term follow-up, 120 (2%) had a recurrent stroke, 314 (5.1%) had MACE, 38 (0.6%) had post-stroke MI, and 37 (0.6%) had post-stroke cardiac revascularization procedures. On multivariate analyses, higher sex-specific TG-HDL index was independently associated with lower adjusted odds of severe stroke and lower inpatient mortality, and higher 1-year adjusted odds of post-stroke MI (p<0.05).
Conclusion: TG-HDL was strongly associated with in-patient mortality and long-term post-stroke cardiovascular outcomes but not long-term stroke recurrence. Our finding of an independently increased 1-year risk of post-stroke MI with higher TG-HDL index may warrant consideration of this index as a cardiac risk stratification tool for stroke patients.
Exploring diagnostic and therapeutic implications of subacute lower motor neuronopathy in the setting of acute lymphoblastic leukemia: A case report
Authors: Li Xueming , Li Xiaoyan , Ding Weijiang
Published: October 2024

Subacute lower motor neuronopathies (SLMN) have not been previously documented in association with acute lymphoblastic leukemia (ALL). We present a case with SLMN during the remission phase of ALL. Our patient, a young teenage male with ALL who was in remission following COTP chemotherapy, manifested weakness in the lower extremities. Following a comprehensive investigations, the patient was diagnosed with SLMN. Muscle biopsy corroborated the diagnosis, with neurogenic muscular atrophy, muscle fiber grouping and target fibers. The patient’s symptom improved on two occasions following corticosteroid therapy but the symptom relapsed upon discontinuation of the medication. This case support the association of SLMN in ALL.
Incidence and risk factors of cognitive impairment in COVID-19 survivors within the first six months and its association with functional outcome
Authors: LAJIM Darwinus , Mazlan Mazlina , Muhamad AMIN Sa’adah , Suhaimi Anwar
Published: October 2024

Background & Objective: There is growing evidence of cognitive decline post-COVID-19, even in mild infection. We aim to evaluate the incidence of cognitive impairment, domains affected, its risk factors and the effect on function during the subacute period when rehabilitation is crucial.
Methods: In this study, the incidence of impaired cognition was assessed in patients at 3 and 6 months post-COVID-19 infection between August 2021 and July 2022 at University Malaya Medical Center, with Montreal Cognitive Assessment (MoCA). The most common cognitive domains affected were identified with descriptive analysis. Associated sociodemographic and clinical factors were analyzed with simple and multiple logistic regression models. The post-COVID-19 Functional Scale (PCFS) was used to assess functional status. The correlation between cognition (MoCA score) and functional status (PCFS scale) was performed using Spearman correlation test.
Results: We recruited 100 patients and found that 44% had impaired cognition at three months and 43% at six months. Patients with secondary education level (p =0.001, OR 13.541), oxygen therapy (p=0.039, OR 7.811), and obesity (p=0.029, OR 4.764) were associated with a higher risk of impaired cognition. The most affected MoCA domains were language, executive function, attention and memory. Lower MoCA score was correlated with higher PCFS grade (lower functional status) (p <0.001, ρ -0.729).
Conclusion: Post-COVID-19 cognitive impairments were common up to 6 months of illness and affect function. Clinicians are advised to perform cognitive screening especially in higher risk patients and provide necessary interventions.
Frequency and outcome of cerebral venous thrombosis attributed to oral contraceptive pills
Authors: Vasaghi-Gharamaleki Maryam , Hooshamndi Etrat , Habibagahi Maryam , Gholamzadeh Mohammad Javad , Molavi Vardanjani Hossein , Fadakar Nima , Ostovan Vahid Reza , Rahimi-Jaberi Abbas , Ashjazadeh Nahid , Petramfar Peyman , Poursadeghfard Maryam , Izadi Sadegh , Nazeri Masoumeh , Bazrafshan Hanieh , Bahrami Zahra , Karimlu Sedigheh , Bayat Mahnaz , Salehi Mohammad Saied , Shakibajahromi Banafsheh , Xiao Yangyang , Sharma Varnika , Goudarzi Roham , Safari Anahid , Van de Munckhof Anita , Coutinho Jonathan M. , Borhani-Haghighi Afshin
Published: October 2024

Background: Oral contraceptive (OCP) use is a significant risk factor for cerebral venous thrombosis (CVT). There is limited research on its association with CVT development in Islamic countries. Therefore, our study aimed to assess the risk of different OCPs in developing CVT and their prognosis.
Methods: This is an observational retrospective single-center cohort study that included CVT patients between March 2018 and March 2021. All CVT participants were registered in the organized registry system (CVT registry code: 9001013381) at the Neurology Research Center of Shiraz University of Medical Science. Univariate analysis and multivariable binary logistic regression modeling were applied to determine the associated factors leading to poor outcome.
Results: A total of 204 patients (139 women, 65 men) were enrolled in the study. Seventy-four females (53.25% of total female patients) used OCPs, with second-generation OCPs being the most commonly used type (70%). OCP consumption was associated with a lower mortality rate (P=0.004, aOR=11.732) and a better 3-month follow-up outcome (p=0.001, aOR=9.882) than their female counterparts who did not use OCPs. The duration and generation of OCPs did not affect the follow-up outcome (P=0.148, P=0.428, respectively) or mortality (P=0.555, P=0.569, respectively). In multivariable analysis, the use of OCPs was a predictor of a favorable 3-month follow-up outcome in females (aOR =4.423, 95% CI: 0.423-46.248).
Conclusion: These results suggest that OCPs may have a positive impact on the prognosis of CVT in women. However, further research is required to understand the underlying mechanisms and validate these findings.
Intestinal pseudo-obstruction in a myasthenia gravis patient after thymectomy: A case report and literature review
Authors: Qian Yun , Yin Congguo
Published: October 2024

Intestinal pseudo-obstruction in patients with myasthenia gravis is a rare and poorly understood phenomenon. We report a case coexisting with intestinal pseudo-obstruction and myasthenia gravis. The patient was diagnosed to have myasthenia gravis and underwent thymectomy seven years ago. He was tested positive for anti-acetylcholine receptor antibody and was free of thymoma recurrence during the current illness. Despite being given gastrointestinal decompression and parenteral nutrition, the patient’s gastrointestinal symptoms did not improve. Symptoms were rectified effectively by immunomodulatory therapy. This case adds intestinal pseudo-obstruction to the phenotypic profile of post-thymectomy myasthenia gravis. High titer of AChR antibody might play a role in the pathogenesis of myasthenia gravis with intestinal pseudo-obstruction.
Validation and reliability of the Malay version of the painDETECT questionnaire (PDQ-M) among patients with neuropathic and nociceptive pain
Authors: Loh Huai Heng , Yee Anne , Velaiutham Shanty , Hussein Zanariah , Haji Mohd Amin Mohamad Zaki , Wan Sharifah Aishah , Tong Chin Voon , Sim Chun Yang , John Lorietta , Tan Florence Hui Sieng , Mohamed Mafauzy
Published: October 2024

Background: Neuropathic pain is chronic and debilitating. Early and accurate diagnosis is important for appropriate management. The painDETECT questionnaire (PDQ) is an effective screening tool for presence of neuropathic pain. We tested the validity and reliability of the translated Malay version of PDQ (PDQ-M).
Methods: This was a multi-center cross-sectional study conducted over 24 months. The original English version of PDQ was translated into Malay version following international guidelines. Subsequently, patients with chronic pain were administered PDQ-M and Malay version of SF36 at baseline and 2-4 weeks later. The reliability, construct and criterion validity of PDQ-M were evaluated. Clinician diagnoses were used as gold standard for comparison of diagnostic accuracy. Multiple regression analysis was performed to determine correlation between PDQ-M and SF-36 scores.
Results: A total of 97 patients were included in the study (53 with neuropathic pain, 44 with nociceptive pain). The EFA of PDQ-M produced three factors which explained 58.3% of the variance. It exhibited fair consistency with Cronbach’s alpha coefficient of 0.719 (for all 9 items) and 0.755 (for 7-item with Likert scale). PDQ-M is reliable with Cronbach’s alpha coefficient of 0.719 and 0.852 for test-retest reliability. A score of ≥17 was the best cut-off value for discriminating between neuropathic and non-neuropathic pain in PDQ-M (79.2% sensitivity, 50.0% specificity). Multiple regression analysis exhibited total PDQ-M score to have significant negative correlation with all components of SF-36 scores except role limitation due to physical health.
Conclusions: PDQ-M is a reliable and valid self-administered screening tool for neuropathic pain.
Unidades de conservação sob a ótica da categoria geográfica paisagem de Milton Santos
Authors: Silva Júnior Antônio Rodrigues da , Gonçalves Rosiane Ferreira , Mendes Glenda Socorro Malcher , Amora Piera Brenda Coelho , Alves Renato de Lima , Vidal Albert Lincoln Costa
Published: October 2024

Este artigo apresenta uma abordagem sobre as Unidades de Conservação (UCs) criadas na Amazônia paraense sob a perspectiva analítica da categoria paisagem conforme proposta por Milton Santos (1988, 2004, 2006) no seu constructo de uma teoria social do espaço. Trata-se de um estudo de natureza teórico-conceitual, com abordagem qualitativa, empreendendo uma análise das UCs por meio das categorias geográficas miltoniana, com o suporte da interdisciplinaridade. A análise das Unidades de Conservação por meio da categoria paisagem se concretiza, na medida em que essas áreas protegidas, numa acepção miltoniana, são fruto da produção do espaço constantemente alterado pelo homem e representam um processo de acumulação e transtemporalidade, uma vez que junta passado e presente numa construção transversal que não mudam de lugar, mas mudam de função, e, portanto, de valor sistêmico. As Unidades de Conservação constituem objeto fruto da ação humana sobre o espaço, que passam por transformações em suas características naturais, sobretudo, do ponto de vista dos avanços das frentes de expansão do agronegócio e do desflorestamento, resultante dos sistemas de valores que alicerçam as ações de diferentes atores sociais cristalizando unidades de paisagens em determinados períodos históricos.
Beyond the Divide Between Qualitative and Quantitative Research: A Comparison of Grounded Theory and Structural Equation Modeling
Authors: Ripani Giulia , Zdzinski Stephen F.
Published: October 2024

Researchers in music education tend to rely on either qualitative or quantitative modes of inquiry. Although scholars are likely to choose one paradigm over the other, no study is purely qualitative or quantitative. To illustrate this point, we aimed to contextualize and discuss both qualitative and quantitative research within a common framework. We then conducted a comparative analysis of a qualitative and a quantitative research approach—grounded theory and structural equation modeling—along a set of philosophical and methodological continua. We showed that grounded theory and structural equation modeling follow a similar overarching research process while integrating both qualitative and quantitative components. Our analysis served as an example to contemplate nuances within research practices and identify similarities between qualitative and quantitative studies. Drawing on this analysis, we highlighted the importance of developing a common research framework in research and education research within the context of music education.
A Study of Factors Influencing Corporate Debt Default
Authors: Huang Yuxiao
Published: October 2024

With the global debt rate rising at a high speed in recent years, the risk of corporate debt default has also increased gradually, in order to explore the influencing factors of corporate debt default and let enterprises better avoid the risk of debt default. This paper discusses the impact of corporate debt default from internal and external, macro and micro levels, from the aspects of corporate investment and financing strategy, management's investment preference, corporate governance structure, corporate strategic positioning and the differences between the same industry, external macroeconomic environment, national policies and international exchange rate impact, and the degree of opening up of the capital market to the outside world. Corporate debt can be influenced by several factors, and a clear understanding of the relationships and mechanisms between the factors will help to propose feasible debt reduction programs that will lead to more robust corporate development.
Application of LSTM neural network in the research of cyclical industries: taking the automotive industry as an illustrative case
Authors: Wang Ziheng , Quan Heng , Gao Yu
Published: October 2024

Anticipating future developmental trends within an industry stands as one of the paramount responsibilities for industry researchers. Nevertheless, owing to the intricate and subjective nature inherent in industry research, coupled with researchers usually having to rely on their own subjective judgments when making predictions, the forecasting outcomes frequently prove unsatisfactory. In order to address this issue, this study introduces deep learning technology into the industry research field and employs Long & Short-Term Memory (LSTM) networks to forecast a typical cyclical industry - the automotive industry. In the specific experiment, Adam optimization algorithm is employed to enhance model training speed, followed by utilization of the grid search algorithm for optimal parameter selection. Subsequently, the obtained optimal model is utilized for LSTM multivariate sequence prediction in order to forecast the future development trend of the automotive industry over the next six months. The ultimate outcome demonstrates that the LSTM model accurately anticipated the forthcoming U-shaped rebound trend in the automotive industry, albeit with some limitations in predicting precise numerical values and timing. Nevertheless, it aligns closely with the actual developmental trajectory. This investigation represents a constructive application of deep learning technology in industrial research, and its final findings hold significant implications for future industry research endeavors.
The Relationship among Environmental, Social and Governance (ESG) Factors
Authors: Chen Siyu
Published: October 2024

As the global economy slows down, enterprise development enters a new stage. In addition to scale expansion, more emphasis is placed on external factors that focus on sustainable development, such as environmental, social and governance (ESG). ESG represents the concept of green economy, emphasizing that enterprises should not develop at the cost of the environment, but should take the initiative to fulfill social responsibilities and protect the rights and interests of stakeholders. In this paper, the comprehensive impact of ESG dimensions on corporate governance is deeply studied. Through the systematic review and analysis of several domestic and international literatures, this paper reveals the key role of strong governance structures in promoting the development and implementation of corporate environmental policies, as well as their central position in enhancing social responsibility and corporate social image. Research shows that good governance can not only improve a company's environmental performance, but also further enhance its financial performance and market competitiveness by improving social interaction and meeting stakeholder needs. This paper emphasizes that the optimization of governance structure is an important strategy for enterprises to achieve sustainable development and increase shareholder
Analysis of Green Merger: Evidence from Anhui Conch Cement Company Limited Getting Anhui Conch New
Authors: Zheng Tian
Published: October 2024

In order to the goal of achieving the carbon peak by 2030, many enterprises had to take the green transition, so the green merger and acquisition came into being, becoming one of the important means of the green transformation of many enterprise, so it is important to investigate whether green mergers can really bring enough performance to enterprises, this study mainly wants to explore based on the example of green merges and acquisitions to find out if green merchandise is really the best option of the Green Transition. The cement industry is the current high carbon emission industry, and the Conch Cement Company Limited as the largest cement production enterprise in China, the obligation and responsibility to lead the green Transformation, so this study has chosen the Conch Cement Company Limited for the purchase of the Conch New Energy Company in 2021, the analysis of the acquisition performance. This study will consider the green and purchase performance, clear green and buy definition and based on the case analysis, from both financial and non-financial performance, measure and make this purchase.
Research on the development of BYD based on SWOT and Financial analysis
Authors: You Chengqian
Published: October 2024

With the continuous maturity of new energy utilization technology in the future, BYD, as a leader in the new energy industry, will usher in a greater development opportunity. Through SWOT analysis of BYD's financial indicators in recent years, we can draw the following conclusions: BYD has a stable financial situation, outstanding technological innovation ability, strong cost control ability, and obvious advantages; However, the market competition is fierce, and brand influence needs to be improved. At the same time, it faces threats such as rapid technological updates and uncertainties in the international trade environment. Therefore, BYD should fully utilize opportunities such as policy support and market demand growth, strengthen brand building and technological research and development, improve market competitiveness, and respond to potential risks and challenges.  In summary, by using the SWOT analysis method to conduct in-depth analysis of BYD's financial indicators in recent years, we can not only understand the company's operating status and competitive advantages, but also discover the challenges and potential risks it faces. This will help investors and decision-makers make more scientific and reasonable strategic decisions, providing strong support for the future development of the company.
Financial Performance Analysis of State-Owned Enterprises' Reverse Mergers Based on Guangdong Hydroelectric Power Corporation's Case
Authors: Ba Jingwen , Miao Jingcheng , Wu Yuxuan
Published: October 2024

In order to improve the competitiveness of state-owned firms, it is crucial to utilize their existing assets effectively and promote efficiency. The state promotes the restructuring and development of pertinent state-owned firms through mergers and acquisitions. This paper assesses the debt-paying ability, profitability, and expansion capabilities of Guangdong Construction Group through financial performance analysis, using the reverse takeover by Guangdong Hydropower as a case study. Dealing with the financial risks and managerial issues in the reorganization of state-owned companies to improve progress and performance. This paper suggests enhancing capital flow, advancing integration strategies post-mergers and acquisitions, clarifying the objectives of mergers and acquisitions, accelerating the optimization of management systems post-mergers and acquisitions, and developing scientifically grounded merger and acquisition plans based on real circumstances. This paper offers advice for state-owned enterprises involved in similar reverse acquisitions or mergers and acquisitions.
The impact of reverse mixed reform on long-term investment with short-term financing of non-state-owned enterprises
Authors: Song Shiyu , Xia Beibei , Shan Yuhao
Published: October 2024

本文探讨了反向混合所有制改革对2007—2022年沪深A股上市非国有企业长期投资和短期融资的影响，重点探讨了股权结构调整策略。研究结果表明，反向混合所有制改革对非国有企业长期短期融资投资水平具有显著的负向影响，PSM 和工具变量法等稳健性检验证明了这一点。此外，进一步的探索表明，这种关系可能会受到放宽财务资源限制和降低代理成本的影响。异质性分析表明，反向混合改革对短期融资长期投资的影响在小企业和监管薄弱的金融区域更为显著。这些见解为理解投融资活动中的行为提供了新的视角，同时加强了公司风险管理和战略决策的理论基础。
A Study of the Impact of Private Equity Funds on the Value of SMEs
Authors: Zhou Xinyi
Published: October 2024

Private equity (PE), a type of equity investment in unlisted companies, has gradually become more popular in the domestic market as a result of China's economy's rapid development. According to certain experts, private equity significantly affects businesses. Less research has been done, though, on how private equity funds affect business value. The focus of this article is therefore the impact of PE on the valuation of SMEs. Based on the GEM data from 2019 to 2022, the empirical analysis of the results by means of multi-linear regression model indicates that the value of private equity firms is higher than that of non-private equity investors, and the lower the balance sheet ratio, the higher the return on net assets ratio, or the higher the research and development intensity of the enterprises participated by private equity institutions, the more conducive it is to increase the value of small and medium-sized enterprises.
Relationship Research between Digital Economy and High-Quality Economic Development on the view of Foreign Trade Opening
Authors: Zhang He , Huang Jinghua
Published: October 2024

Digital Economy (DE), as a vital impetus for high-level openness, interacts with High-Quality Economic Development (HQED). Researching Coordination mechanism among these three aspects carries substantial weight in a country to achieve common prosperity and strategic goals. Based on this premise, this paper first uses provincial data from 2014-2021 as the research object, measuring the levels of Digital Economy and HQED Employing the comprehensive index, Entropy Weight Method and critic weight. It also employs the coefficient of variation, Theil index, and coefficient of dispersion to analyze the trends in regional disparities concerning the development of DE and HQED. Subsequently, the Dynamic interaction model, grounded in the entropy weight method, was employed to quantitatively assess the coupling coordination between DE and HQED. Then, the random forest model was used to explore the impact of constituent indicators regarding the coupling coordination between the two systems, with XGboost and LASSO models serving as supportive evidence. Empirical analysis results indicate that, on one hand, the disparities in HQED among regions showed an initial increase followed by a decrease, while the disparities in Digital Economy development among regions demonstrated a year-over-year decreasing trend. On the other hand, during 2014-2021, the disparities in harmony with DE and HQED among regions decreased annually. Additionally, foreign-trade dependence and share of foreign investment are found to be significantly important to Coupling efficiency.
Business-Government Relations in Domestic and International Marketplaces
Authors: Gong Jinda
Published: October 2024

Over the past few years, there has been a sharp increase in the number of electric vehicles (EVs) in China. Laws and incentives encouraging EV adoption have strengthened the domestic relationships between Chinese EV companies and the Chinese government, compared to their partnerships with other governments. Internationally, Chinese electric vehicle firms often face limited government support due to trade barriers and geopolitical conflicts that affect their operations. This paper explores the Chinese electric vehicle industry, highlighting its positive role in international trade and its potential threat to foreign manufacturers. It also recommends that the domestic government adopt a data analysis methodology to facilitate expansion and enhance competition among domestic firms through subsidies and tax incentives.
BIOSYNTHESIZE NANOPARTICLES AS ADVANCED NANOCARRIERS FOR TARGETED THERAPEUTIC INTERVENTIONS IN DISEASE MANAGEMENT
Authors: JANNAT A , BALQEES K , HASNAIN M , ASHIQ M , MUZAMMAL F , JAVAID Z , SAEED Z , BAIG MH , MUMTAZ T , RAUF U
Published: October 2024

Biosynthesized nanoparticles have emerged as cutting-edge nanocarriers for targeted therapeutic interventions in illness management, transforming medication delivery and treatment techniques. These nanoparticles provide a biocompatible and sustainable substitute for conventional synthetic processes since they are made utilizing biological systems including fungi, bacteria, and plants. They are perfect candidates for precision medicine because of their innate capacity to lower toxicity and increase bioavailability. Because of their distinct surface characteristics, biosynthesized nanoparticles are easily functionalized with therapeutic drugs, allowing for targeted distribution to sick cells or certain organs while reducing off-target effects. Additionally, the large surface area-to-volume ratio and nanoscale size promote better cellular absorption and regulated drug release, enhancing therapeutic efficacy. These nanoparticles' natural origin lowers their immunogenicity and adverse response risk, which enhances patient outcomes even more. Biosynthesized nanoparticles have demonstrated great promise in cancer therapy, including the ability to target tumor cells specifically, carry chemotherapy medications, and even combine with imaging agents for theragnostic uses. They also show promise in improving therapy specificity and lowering adverse effects in other diseases like infectious diseases, cardiovascular ailments, and neurological disorders. This study covers the developments in biosynthesized nanoparticles as nanocarriers, highlighting their importance in altering illness management through tailored therapeutics while evaluating the limitations and future prospects for their clinical translation.
A note on ex-situ conservation and multiplication through air layering of Syzygium travancoricum Gamble- A critically endangered, endemic tree species of the southern western ghats
Authors: Shareef Sainudeen , Thulasidas G.
Published: October 2024

Syzygium travancoricum Gamble (Myrtaceae) is one of the critically endangered, endemic species of the Southern Western Ghats of Kerala and Tamil Nadu. Inferior seedling survival and habitat destruction might be the reasons for its endangerment, which demands urgent ex-situ and in-situ conservation. The paper discusses the multiplication of this species through air layering carried out as part of its ex-situ conservation.
Участие специалиста-кинолога в раскрытии и расследовании преступлений
Authors: Иванова Е.В.
Published: October 2024

Служебно-разыскные собаки при раскрытии и расследовании преступлений применяются для поиска по запаху человека, целевых веществ, трупов и т. д. Результаты такого применения являются одним из источников оперативной и доказательственной информации. Однако в настоящее время остаются нерешенными вопросы доказательственного значения акта применения служебной собаки, процессуального статуса кинолога, отсутствуют требования к его профессиональным компетенциям и т. д. В статье рассмотрены вопросы процессуального статуса специалиста-кинолога при производстве следственных действий. Предложено установить отдельной нормой УПК РФ порядок его участия в расследовании преступлений. Рассмотрены факторы, влияющие на эффективность применения собаки в поисковой деятельности. Обоснована целесообразность применения для дрессировки и тренировки собак запаховых проб вместо имитаторов при отсутствии у кинолога натуральных веществ.

Search dogs are used in the detection and investigation of crimes to search by the smell of a person, targeted substances, corpses, etc. The results of such an application are one of the sources of operational and evidentiary information. However, at present, the issues of the evidentiary value of the act of using a service dog, the procedural status of a dog handler, and the lack of requirements for his professional competencies remain unresolved. The article discusses the issues of the procedural status of a cynologist in the production of investigative actions. It is proposed to establish a separate norm of the Criminal Procedure Code of the Russian Federation for the procedure of his participation in the investigation of crimes. The factors influencing the effectiveness of using a dog in search activity are considered. The expediency of using odor samples for training and training dogs instead of imitators in the absence of natural substances from the dog handler is substantiated.
Актуальные проблемы тактики допроса вневедомственного эксперта на стадии предварительного следствия
Authors: Таранов Н.В.
Published: October 2024

В статье исследуются проблемы тактики проведения допроса эксперта вневедомственной экспертной организации на основе анализа способов противодействия с его стороны. Проблемы рассмотрены с криминалистической, психологической и процессуальной сторон деятельности следователя. Автором статьи разработаны тактические приемы допроса эксперта, в том числе с использованием видео-конференц-связи.

The article examines the problems of tactics of interrogation of an expert of a non-departmental expert organization based on an analysis of the ways of counteraction on his part. The problems are considered from the criminalistics, psychological and procedural sides of the investigator's activity. The author develops tactical techniques of interrogation of the expert, including the use of video conferencing.
Using machine learning to predict Apple Inc.s stock returns and develop a hedging strategy for investors
Authors: Han Yihang
Published: October 2024

This report aims at investigating the relationship between the returns of Apple Inc. and the market returns by using the machine learning model. Nine months of historical financial data for Apple and market was utilized as the training data set, predicting the return of Apple in future three months. Within this research, my findings suggest that there is a significantly positive correlation between Apples returns and the market returns, which indicates that it is acceptable to forecast Apples performance through the market index, and any market fluctuation tends to have a pronounced impact on Apple. Based on the effective analysis of Apples future returns, we can propose valid hedging strategies for investors to eliminate risks from both upward and downward price trends.
Pan-cancer analysis of TP53 mutations and their association with liver cancer and aristolochic acids
Authors: Zhao Zhetao
Published: October 2024

Liver cancer is a major global health concern, as its incidence continues to rise in numerous countries, making it a leading cause of cancer-related deaths. The TP53 gene, which encodes the p53 tumor suppressor protein, plays a crucial role in regulating cell growth and division. Mutations in TP53 have been implicated in increased risk for liver cancer development. In this study, we aim to conduct a pan-cancer analysis to further investigate the potential role of TP53 mutations in various cancer types and their relationship with liver cancer. Additionally, we will explore the interplay between TP53 gene mutations, liver cancer, and exposure to Aristolochic acids (AAs). To achieve these goals, we will utilize data from The Cancer Genome Atlas (TCGA) project and the Gene Expression Omnibus (GEO) databases, enabling a comprehensive analysis of TP53 in the context of multiple cancer types.
The role of recommendation algorithms in driving the development of e-commerce platforms
Authors: Pan Yiyang
Published: October 2024

Given the rapid development of e-commerce, recommendation algorithms play a crucial role in enhancing user experience and promoting platform growth. This paper delves into the application of recommendation algorithms within e-commerce platforms, scrutinizes the advantages and disadvantages of collaborative filtering, content-based recommendation, and hybrid recommendation models, and elucidates how these algorithms can enhance user stickiness, improve conversion rates, and promote the overall growth of platforms through personalized recommendations. Through empirical case studies, the author demonstrates how recommendation algorithms can optimize the user shopping experience and enable e-commerce platforms to differentiate themselves in a fiercely competitive market. This research not only aids e-commerce platforms in improving operational efficiency and market competitiveness but also provides valuable practical insights and theoretical support for the fields of data science and artificial intelligence.
Intelligent quotient of late treated phenylketonuric patients: is brain damage still preventable?
Authors: Elrfifi Kamila , Zeglam Adel , Zeletini Mabrouka , Abourey Fawzia , Alhmidi Souad
Published: October 2024

Over the past 30 years and since the first trial to treat phenylketonuria (PKU) by Horst Bickel and his coworkers, the dietary treatment of PKU has produced a generation of adult women with PKU who have minimal cognitive deficits and are now of child-bearing age. If PKU is detected early enough in infancy, mental retardation can be prevented by giving a diet containing a restricted amount of phenylalanine. The principle of therapy is that all newborn babies with phenylalanine concentration of 360 µmol or above are to be treated as early as possible to achieve a higher mental function in terms of intelligence quotient, blood phenylalanine levels should be maintained in the range of 120 - 360 µmol/l. Subnormal as well as high phenylalanine levels are to be avoided. In the last few years there are increasing published articles on late treated PKU patients. In these patients, the mean IQ was 57. For those treated after 2 months of age, recent studies have suggested that approx. 23% of those children have normal IQ. In our hospital most of our cases were late treated (15 patients out of 22), the age at which treatment was started ranges from 2 weeks to 9 years.  It is noted that those patients who were diagnosed before 2 years of age (6 children) and were on strict phenylalanine low diet with a phenylalanine maintained less than 4mg/dl have a normal IQ (75 or above) (6 patients), one child  has difficulty in speech, 2 children  had border line IQ (above 70 and less than 75), two children had moderate learning difficulties (IQ above 35 and below 50), 4 children had severe learning difficulties (IQ above 20 and less than 35 of which two of them diagnosed before 2 years of age.
Effects of Obesity in Male Fertility in Khartoum State
Authors: Idrees Khadeeja Yahya Othman , Elhaj Roaa Mohamed Ahmed
Published: October 2024

Obesity is a severe medical condition causing health issues and reducing life expectancy, affecting 400 million adults and 1.6 million overweight individuals, is a severe medical condition affecting fertility, with extreme obesity causing fertility issues. This study aimed to investigate the effect of obesity on male fertility in Khartoum state; it is a cross-sectional facility-based study studying All males of Infertile couples who come to the infertility clinic. The study discussed patient demographics, past medical and surgical history, and self-reported male sexual dysfunction in addition to the factors that affect male infertility, Body Mass Index (BMI), and spermatic parameters (motility, morphology, concentration) by seminal analysis. The statistical package SPSS 23.0 was used for analysis. The study revealed that 40 men (20.5) were of age <30 years old, 57 men (29.9%) of age 30 – 40 years old, and 98 men (50.3%) were of age >40 years old. “One hundred five men (53.8%) were from North Sudan”, “58 men (29.7%) were from Eastern Sudan,30 men (15.35%) were from Western Sudan overweight, and 2 men (1.15%) were from Southern Sedan, 56 men (28.7%) have BMI <25,81(41.5%) had BMI 25 -30 and 58(29.8%) have BMI of >30, 110 men (56.4%) have normal sperm counts and 85 (43.6) have abnormal sperm counts, 105 men (53.8%) have normal sperm morphology”. In contrast, 90 (46.2) have abnormal morphology. Eighty-eight men (45.1%) have progressive motility, while 107 men (54.9%) have impaired motility. Fifty-six men (28.8%) of participants have erectile dysfunction, while 139 (71.2%) have not. It concluded that increasing the age of the male partner increases the risk of infertility, and ethnicity has an unclear effect on infertility and still needs further studies to prove it. Obesity rates are increasing among men in Khartoum, impacting seminal parameters like motility and erectile dysfunction, as highlighted in a study.
Gram-Negative Bacteremia: Epidemiology and Antimicrobial Resistance in Qatar
Authors: Shaukat Adila , Chaponda Masautso , Al-Wali Walid , Maher Farah , Al-Balushi Sara , Maliyakkal Abdulmajeed , Elhakeem Israa , Al-Saadi Tahani , Omrani Ali , Al Maslamani Muna
Published: October 2024

One of the major causes of morbidity and mortality in hospitalised patients is the presence of gram-negative bacteremia (GNB) in blood. The developed resistance among the bacteria poses a significant challenge for treatment. The study aimed to identify the gram-negative patient’s epidemiological risk factors, antimicrobial susceptibility patterns, and clinical outcomes. A retrospective observational study of adult in-patients with gram-negative bacteremia was conducted between January 2019 and December 2020 in the 320-bed general hospital in Qatar. Data on demographics, antimicrobial resistance, source of infection, and treatment were collected. The primary outcomes were patients’ cure, death, or relapse. Total of 357 patients were identified with bacteremia, the most common sources being urinary tract infections (39.6%), intra-abdominal infections (28%), and lower respiratory tract infections (9%). The mean duration of the intravenous and oral antibiotics administration was 14 days. Surgical source control was performed in 35.7% of patients. Common pathogens were Escherichia-coli (47.2%), Klebsiella pneumoniae (16.4%), Salmonella enterica serotype Typhi (10.6%), and Pseudomonas aeruginosa (7.8%). 67.32% fully susceptible strains, 31.56% extended-spectrum beta-lactamase (ESBL) producing bacteria, and 1.11% multidrug-resistant organisms (MDROs) were among the isolates. Most infections (68%) were cured, but 5% had recurrence within 90 days of admission. Infection-related mortality was 8%, and death due to non-infectious causes was 2%. In conclusion, Gram-negative BSIs are severe infections with increasing antimicrobial resistance, primarily caused by ESBL-producing bacteria. High mortality rates are linked to diabetes, age, and hospitalisation, necessitating antibiotic treatment optimisation.
Human Immune Responses to Measles Virus: A Literature Review
Authors: Albarbar Balid
Published: October 2024

Measles disease is caused by the measles virus (MV), is a highly contagious viral infection that mainly affects children. Measles disease is one of vaccine-preventable diseases (VPDs), despite the availability of an effective vaccine, measles remains a significant public health concern globally.
Understanding the immune responses to the measles virus is very important for the development of improved vaccines and therapeutic strategies. The aim of the current study is to summarize current knowledge on the innate and adaptive immune responses to measles infection, including the role of various immune system components; cells, cytokines, and antibodies. In addition to that, the paper discusses the immunological memory generated following measles infection or vaccination and its implications for long-term protection.
Pathology and molecular detection of influenza Asubtype H9N2 virus in commercial poultry in Nigeria, 2024
Authors: Akanbi Olatunde , Alaka Olugbenga , Olaifa Olanrewaju , Meseko Clement , Inuwa Bitrus , Ohore Obokparo , Tijani Monsuru , Jarikre Theophilus , Ola Olawale , Odita Christianah , Ahmed James , Fagbohun Olusegun , Oluwayelu Daniel , Daodu Olufemi , Oladele Omolade , Olapade James , Taiwo Olusegun , Muhammed Maryam
Published: October 2024

Background:
After the first Avian Influenza H5N1 outbreak in Nigerian poultry in 2006, subsequent waves of outbreaks occurred, causing substantial losses. Despite effective control measures by 2008, a resurgence in 2015 led to further losses and required depopulation efforts.
Aim:
The aim of this study was to do Pathology and molecular detection of influenza A subtype H9N2 virus in commercial poultry in Nigeria during 2024.
Methods:
In February 2024, a poultry farmer reported high mortality in his mixed commercial poultry flock in Ibadan, Nigeria, submitting carcasses to the University of Ibadan's V.T.H. and the FAO Regional Laboratory at NVRI, Vom.
Results:
Necropsy of nine Isa Brown layers and three Abor Acre broilers revealed cyanosis of comb and wattles, generalized petechial and ecchymotic haemorrhages including shank haemorrhages with sinusitis, pneumonia, and severe greenish faecal pasting also observed. At histopathology, denudation of the tracheal epithelia and parabronchial epithelial necrosis, obliteration, with airsac oedema and emphysema were observed. At NVRI, qPCR detected an Influenza A H9N2 virus in several pooled organ samples of layers, and broilers and eliminating the avian infectious bronchitis and Newcastle disease viruses.
Conclusion:
This is the first report of H9N2 outbreak in commercial poultry in Southern Nigeria. The high pathogenicity shown in commercial poultry in this outbreak and the risk of dispersal of infected live poultry in Nigeria as previously seen in H5N1 require stakeholders’ intervention.