bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of the SNPs in CCL2 and CXCL12 genes with the susceptibility to breast cancer: a case-control study in China
Authors: Zhao Duanchong , Yu Xingxing , Huang Hongli , Zou Shuqing , Zhu Pingxiu , Lin Yuxiang , Song Mengjie , Fu Fangmeng , Yang Haomin
Published: December 2024

Background

Chemokines are well-known for playing an essential role in the development of cancer. However, the association between SNPs in the CCL2 and CXCL12 genes and the susceptibility to breast cancer remains unclear.

Methods

A case-control study was conducted in southeast China, including 1855 breast cancer patients and 1838 cancer-free controls. The association between single nucleotide polymorphisms (SNPs) in the CCL2 and CXCL12 genes and the susceptibility to breast cancer was investigated using logistic regression models. The association between plasma CCL2 and CXCL12 with breast cancer was further examined in 72 patients and 75 controls.

Results

The CXCL12 SNP rs3740085 was associated with breast cancer in the additive model (OR=1.15, 95%CI=1.01-1.32), particularly in postmenopausal women. The association between rs1024611 in CCL2 and breast cancer was only found in women with a BMI of ≥24kg/m2. SNPs in the CCL2 gene were mainly associated with PR-positive breast cancer, whereas rs1144471 in CXCL12 was associated with ER-negative (OR=0.43, 95% CI=0.23-0.84), PR-negative (OR=0.38, 95% CI=0.19-0.74), and HER-2-positive (OR=1.27, 95% CI=1.03-1.56) breast cancer. The interaction between rs1801157 and rs3740085 in CXCL12 SNPs was statistically significant, and rs3740085 was also associated with breast cancer survival. Additionally, we found a strong association between plasma CXCL12 and breast cancer.

Conclusion

CCL2 and CXCL12 SNPs are associated with breast cancer susceptibility in overweight and postmenopausal women, and the effect varies according to subtypes. The interaction of SNPs within CXCL12 gene and the association with breast cancer survival further suggest potential targets for improved risk assessment and treatment strategies.
Sperm-Borne Mitochondrial Activity Influenced by Season and Age of Holstein Bulls
Authors: Anwar Khurshaid , Thaller Georg , Saeed-Zidane Mohammed
Published: December 2024

Sperm mitochondria are vital organelles for energy production and pre- and post-fertilization sperm functions. The potential influence of the age of the bull and season on the sperm-borne mitochondrial copy number and the transcription activity has not yet been investigated. Therefore, the expression patterns of all protein-coding mitochondrial genes were identified throughout the year along with mitochondrial copy numbers in young and old bulls’ spermatozoa. For that, high-quality semen samples (n = 32) with more than 80% quality for the morphological parameters, from young (n = 4, aged 18–24 months old) and old (n = 4, aged 40–54 months old) Holstein bulls, were collected during the four seasons (n = 4 samples each animal/season). The DNA and RNA were isolated from sperm cells and subjected to the DNA copy number and expression analyses using qPCR. Furthermore, an in silico analysis using gene ontology online tools for the abundantly expressed genes was utilized. The data were statistically analyzed using Prism10 software. There was a significant reduction in the mitochondria copy number of young bulls’ spermatozoa compared to their old counterparts during the summer (29 ± 3 vs. 51 ± 6, p < 0.001) and winter (27 ± 3 vs. 43 ± 7, p < 0.01) seasons. However, sperm-borne mitochondrial protein-coding genes were transcriptionally higher in young bulls throughout the year. Within the same group of bulls, unlike the old bulls, there was a significant (p < 0.05) induction in the transcription activity accompanied by a significant (p < 0.05) reduction in the mitochondrial copy numbers in the summer (29 ± 3) and winter (27 ± 3) compared to the spring (42 ± 9) and autumn (36 ± 5) seasons in young bulls. Additionally, the pathway enrichment of the top six expressed genes differed between age groups and seasons. In conclusion, under the same quality of semen, the early stages of age are associated with mitochondrial biogenesis and transcription activity dysregulation in a season-dependent manner.
Some Worries About Deontic Closure
Authors: Kimble Kevin
Published: December 2024

The Deontic Principle of Closure (DCL) appears initially to be a highly plausible principle. The DCL is commonly assumed in practical ethical reasoning, as when we make certain inferences about what we (morally) ought to do in particular situations. For example, if I am standing beside a burning house with several victims trapped inside and I have an obligation to rescue them, then if it is necessary for me to open the front door in order for me to lead them out, then it seems that I am morally bound in this situation to open the door. Similarly, if it is the case that I ought to keep my Friday morning 8:00 appointment with my student and it is a necessary condition for keeping the appointment that I wake up some time before 8:00, then I ought to wake up before 8:00. In spite of its attractiveness, however, various worries have been raised about the plausibility of this closure principle. In what follows, I shall critically examine DCL and discuss its plausibility in the face of various objections that have been raised against it. I shall argue that a slightly modified version of the principle circumvents the main objections and holds under several of the more or less standard interpretations of the “ought” operator.
Current approaches to psychopharmacotherapy of post-traumatic stress disorder
Authors:   State Budgetary Healthcare Institution of the city of Moscow «Psychiatric Clinical Hospital No. 13 of the Department of Healthcare of the City of Moscow», Moscow, Russia, Dzhafarova N. A. , Evdokimova T. E. ,   State Budgetary Healthcare Institution of the city of Moscow «Psychiatric Clinical Hospital No. 13 of the Department of Healthcare of the City of Moscow», Moscow, Russia, Kalinkin D. S. ,   State Budgetary Healthcare Institution of the city of Moscow «Psychiatric Clinical Hospital No. 13 of the Department of Healthcare of the City of Moscow», Moscow, Russia, Ter-Israelyan A. Yu. ,   State Budgetary Healthcare Institution of the city of Moscow «Psychiatric Clinical Hospital No. 13 of the Department of Healthcare of the City of Moscow», Moscow, Russia
Published: December 2024

Due to the increase in the number of local wars and armed conflicts, the incidence of stress disorders
is increasing in the population. In recent decades, there has been a distinct increase in the number of scientific studies of combat stress problems and an increase in publications on this topic, with a shift in emphasis in the
contents of domestic articles on combat stress from medical problems to its socio-psychological consequences.
Post-traumatic stress disorder (PTSD) is a mental disorder that develops as a result of a powerful psychotraumatic effect of a threatening or catastrophic nature, accompanied by extreme stress, the main clinical manifestations
are repeated experiences of elements of a traumatic event in a «here and now» situation in the form of flashbacks, recurring dreams and nightmares, which is accompanied more often by anxiety and panic, but possibly also anger anger, feelings of guilt or hopelessness, the desire to avoid internal and external stimuli that resemble or are associated with a stressor. This study provides an overview of modern, primarily foreign approaches to psychopharmacotherapy of PTSD and analyzes their reflection in domestic standards and recommendations.
Tari Anak dalam Perspektif Perkembangan Intelektual, Sosial Emosional, dan Multikultural
Authors: Purnomo Eko , Hartono Hartono
Published: November 2024

Kajian ini bertujuan untuk mendeskripsikan tentang tari anak dalam perkembangan intelektual, sosial emosional, dan multikultural. Teknik pengambilan data menggunakan studi dokumen dan pustaka. Teknik analisis data menggunana deskriptif analitik. Masa anak merupakan masa emas perkembanngan intelektual, sosial emosional, dan multikultural. Pada masa inilah intervensi yang dilakukan dapat efektif dan efisien. Pada kemampuan intelektual menekankan pada berpikir kritis, kreatif, dan logis. Pada sosial emosional menekankan pada pembentukan sikap dan krakter. Pada multikultural menekankan pada kemampuan memahami budaya di lingkungan sendiri dan budaya di lain daerah. Pengenalan budaya ini dilakukan agar setiap anak memiliki rasa toleransi, saling menghargai, dan saling menghormati perbedaan budaya yang ada. Hasil analisis menunjukkan bahwa tari anak dapat dijadikan sebagai salah satu media untuk mengembangkan kemampuan intelektual, sosial emosional, dan multikultural.
Blended Learning Musik Kolintang dalam Ekologi Budaya
Authors: Sudarno Sudarno
Published: November 2024

Penelitian ini bertujuan untuk menjelaskan blended learning materi video praktik musik Kolintang dalam ekologi budaya sebagai sumber belajar. Proposisi Holden tentang emergence, growth, complex independent, evolution, web dan networking, convergence dan Sistemic Fragile menjadi pisau bedah dalam menjelaskan teks konteks materi video praktik musik Kolintang. Metode penelitian menggunakan deskripsi kualitatif, karena video praktik musik Kolintang dibuat untuk diversifikasi transfer ilmu pengetahuan dan ketrampilan sehingga tercapai kemandirian belajar mahasiswa selain itu untuk mendukung pembelajaran tatap muka. Teknik pengumpulan data menggunakan studi literature, observasi dan wawancara dengan analisis SWOT. Hasil penelitian menunjukan bahwa implemnetasi teknoogi dan kemunculan materi-materi berupa video praktik musik Kolintang  memberikan pengetahuan dan pemahaman bermain musik kolintang mahasiswa, ilmu tentang sejarah kolintang, nama-nama instrumen dalam ansambel dan pola garapan sehingga proses evolusi dan saling ketergantungan berbagai elemen memberikan kestrabilan ekologi budaya.
Proses Regenerasi Penari Jaranan Kelompok Anak di Grup Satrio Bokor Kecamatan Tumpang Kabupaten Malang
Authors: Suprihatin Endang Wara , Sumarwahyudi Sumarwahyudi , Hidajat Robby , Zandra Rully Aprilia , Yatim Heriyati , Rahman Amalia Arifah
Published: November 2024

Penelitian ini bertujuan untuk mendeskripsikan proses regenerasi penari Jaranan anak-anak dalam kelompok Satrio Bokor (SB). Pemilihan SB sebagai subjek penelitian didasarkan pada statusnya sebagai satu-satunya grup Jaranan di Kecamatan Tumpang, Kabupaten Malang, yang memiliki penari anak-anak berusia 4 hingga 15 tahun. Penelitian ini menggunakan metode deskriptif kualitatif dengan teknik pengumpulan data melalui wawancara terhadap lima informan, observasi, serta dokumentasi. Verifikasi data dilakukan menggunakan triangulasi sumber dan triangulasi teknik. Hasil penelitian menunjukkan bahwa: 1) proses regenerasi dilakukan dengan pola internal menggunakan sistem regenerasi horizontal transmission, di mana proses pengetahuan dan keterampilan diwariskan secara sejajar antar anggota kelompok; 2) pelatihan dilaksanakan melalui pembelajaran langsung dan terbimbing. Temuan ini memberikan pemahaman mengenai pentingnya strategi regenerasi dalam menjaga keberlanjutan tradisi Jaranan di kalangan anak-anak di wilayah Tumpang.
Efektivitas Silika (SiO2) Dari Tanah Napa Situjuah Sebagai Adsorben Ion Logam Pb2+
Authors: Melan Putri , Mawardi Mawardi
Published: November 2024

Silika merupakan salah satu mineral yang memiliki banyak kegunaan di berbagai industri seperti keramik, semen dan bangunan, kosmetik, biosensor dan lain sebagainya. Pada umumnya, silika dapat diperoleh dengan cara sintesis dan ekstraksi dari bahan alam yakni salah satunya mineral tanah napa yang memiliki kandungan silika yang tinggi di dalamnya yang dapat diekstraksi dengan menggunakan pelarut basa seperti NaOH. Silika ini nantinya dapat dimanfaatkan sebagai adsorben dalam penelitian dengan logam seperti logam timbal. Penelitian ini bertujuan untuk mengetahui kapasitas adsorpsi maksimum silika terhadap ion Pb2+ dengan menggunakan metode kolom yang berhubungan dengan pengaruh konsentrasi, pH, laju alir dan aplikasi pada sampel real serta menentukan kapasitas serapan maksimum dan afinitas penyerapan adsorben ditetukan dengan Persamaan Isoterm Langmuir dan analisa logam dilakukan dengan instrument AAS dan menentukan kristalinitas silika dengan XRD. Hasil penelitian ini menunjukkan bahwa konsentrasi optimum adalah 300 mg/L dan ph larutan optimum adalah 4. Hasil penelitian menunjukkan bahwa Qmaks ion logam Pb(II) sebesar 11,061 mg/g dan ukuran kristal sebesar 48,76 nm.
Non-Hermitian Dynamics without all-to-all Coupling in Odd-Channel Systems
Authors: Özgün Ege
Published: November 2024

Here we analytically derive the eigenspectra of non-Hermitian systems with an odd number of channels in a scheme that eliminates the requirement of all-to-all coupling of the channels. The calculated spectrum displays coexisting parity-time broken and parity-time symmetric modes for any choice of coupling and gain/loss values except for the case of N=3 where a certain range of coupling and gain/loss parameters are required for the coexistence of parity-time broken and parity-time symmetric modes.
Uso e efeitos colaterais do cloridrato de fluoxetina em adolescentes
Authors: Pasa Luma Monique Tonial , Filho José Roberto Alves
Published: December 2024

Atualmente a depressão em adolescentes vem sendo um assunto cada vez mais recorrente, o suicídio acomete grande parte da população mundial, prevalecendo em adolescentes. Nesta faixa etária entre 10 e 19 anos de idade, os adolescentes enfrentam muitos desafios emocionais impactando significativamente em seu bem-estar e desenvolvimento. Relacionado a esses fatores, os antidepressivos são prescritos para tratar diagnósticos de transtornos mentais, como a depressão e a ansiedade. Desta maneira, as orientações de promoção em prevenção de saúde provindas dos profissionais da saúde são indispensáveis, em especial as orientações do farmacêutico na orientação do uso de medicamentos antidepressivos. O desenvolvimento desta pesquisa se constitui em torno da temática abordando as questões que envolvem o uso de antidepressivos em adolescentes, em específico nos questionamos sobre o uso do Cloridrato de Fluoxetina e sua influência nos diversos aspectos clínicos, éticos e psicossociais em adolescente. Esta pesquisa se constitui a partir de uma abordagem metodológica de revisão de literatura. O principal objetivo desta pesquisa é explorar os diversos aspectos clínicos, éticos e psicossociais que envolvem o uso do Cloridrato de Fluoxetina em adolescentes. Especificamente compreender a atuação farmacêutica perante a dispensação de antidepressivos; abordar as questões que envolvem o uso de antidepressivos em adolescentes e avaliar os potenciais riscos e efeitos colaterais do Cloridrato de Fluoxetina.
Reabilitação oral com próteses fixas e implantossuportadas para restabelecimento da função, estética e bem-estar psicológico: relato de caso
Authors: Bisinella Ediana Amanda Piana , Silva Victor Miguel Gonçalves , Micharki André Luiz , Naufel Fabiana Scarparo , Pezzini Rolando Plümer , Pezzini Maristela Maria Galina , Queiroz Karolina Fernanda Abegg , Bohneberger Gabriela
Published: December 2024

A procura por um sorriso belo tem aumentado na odontologia, além disso, as expectativas do paciente com a estética, função e conforto podem desencadear problemas como ansiedade, insegurança e baixa autoestima. Somado a isso, a perda dentária provoca problemas estéticos, na mastigação, fonação e causa envelhecimento precoce. A reabilitação oral pode restabelecer a harmonia perdida entre função e estética, promovendo o bom funcionamento do sistema mastigatório. Ademais, com o desenvolvimento de novos materiais e técnicas restauradoras é possível alcançar um resultado desejável, promovendo a saúde e autoestima do paciente. Dentre os materiais disponíveis para a reabilitação funcional e estética está a cerâmica odontológica, capaz de reproduzir a estrutura dental quanto aos efeitos ópticos, reflexão de luz, translucidez, textura e forma. Assim, o objetivo desse trabalho é relatar um caso clínico de reabilitação oral envolvendo próteses sobre implante, próteses fixas unitárias e múltiplas e facetas em cerâmica, com o objetivo de restabelecer a funcionalidade e estética, consequentemente melhorando a autoestima da paciente.
Effect of exogenous application of proline on antioxidant enzyme activities and lipoperoxidation content of faba bean (Vicia faba l.) Under cadimium stress
Authors: Assia Amri , Soumaya Boubsil , Radia Draiaia , Houda Oumri
Published: December 2024

Field experiment we attempted to clarify the mechanism that might be involved in the ameliorative effects of proline on faba bean plants grown under different Cd levels. The effect of proline on MDA, glutathione contents, antioxidant enzyme activities and menbrane stability.These were studied in plants grown in a nutrient solution supplemented with different concentrations of Cd (0 or 150μmol/l) and sprayed with proline with different concentrations (0, 25 or 50mg / l). Heavy metal stress caused an increase in malondialdehyde (MDA) content and the activity of certain enzymes, but glutathione were strongly depressed at relatively high Cd levels. Application of proline caused a significant increase in ascorbate peroxidase (APX) and catalase (CAT) activity in the plant compared with untreated plants. Antioxidant activities are enhanced, helping to reduce oxidative damage and develop tolerance to heavy metal stress in proline-treated bean plants. This proline induced increase in tolerance to heavy metal stress. The results show that treatment with α-tocopherol reduced the adverse effects of Cd stress on bean plants and may play a key role in stress tolerance.
Reuse of the Gipuzkoan Megalithic Landscape: From Ceremonial Sites to Livestock Farming and Hunting
Authors: Uranga Izaskun Egilegor
Published: December 2024

For several decades now, the landscape has been studied from multiple fields due to its complexity and the wide variety of aspects it encompasses. Each discipline approaches the landscape from a particular perspective, analyzing both its physical characteristics and its cultural, social, and symbolic dimensions. Research has emphasized the reuse of the landscape, considering the living societies of the past and their evolution. The megalithic phenomenon follows the same diachronic line. For years, megalithism has been treated as a prehistoric element without understanding its reuse by different contemporary communities around it. The use of these elements has been prevalent throughout history, and it has been varied. Local communities have used these elements for purposes ranging from quarries for the extraction of raw materials to other types of functions. Therefore, it is necessary to understand megalithism as an evolutionary phenomenon connected to the changes in local communities. Thus, the reuse of the landscape and its resources along with subsequent societies, basing the study on the understanding of these elements that have come down to us as heritage to the present day. For this, the bidirectional socialization of megalithic heritage must be considered and studied in future research.
Edukasi pencegahan stunting pada calon ibu, ibu hamil, bayi dan balita
Authors: Rahmadini Annisa Fitri , Andirni Abdya , Putri Angelika , Destiara Afifah , Pramesti Novira Bela
Published: November 2024

Latar Belakang: Stunting adalah keadaan ketidak mampuan untuk berkembang dan masalah nutrisi berkelanjutan yang disebabkan oleh kurangnya asupan makanan karena pemberian makanan yang tak bersesuaian kebutuhan dalam periodik waktu yang lama.Metode: Metode yang digunakan meliputi metode ceramah, metode pre test dan metode post test.Hasil: Memperlihatkan bahwa pendekatan edukasi sangat baik dapat dilihat bahwa perluasan nilai peserta yang menjadi meningkat  setelah materi dan penyuluhan. Peningkatan pengetahuan peserta sangat baik dan mereka dapat memahami betapa pentingnya mengetahui pencegahan stunting pada kehamilan.Kesimpulan: Upaya untuk mengatasi permasalahan hambatan di daerah merupakan sebuah pendekatan penting yang harus dilakukan terus-menerus agar informasi yang terbuka mengenai hambatan dapat terus ditingkatkan.
Manajemen ansietas melalui pemberian benson relaxation pada kelompok lansia penderita hipertensi
Authors: Aini Khusnul , Mamlukah Mamlukah , Yunita Refinda , Fitriyani Devi , Agung Eki Rios Cipta
Published: November 2024

Latar Belakang: Lansia yang mengalami hipertensi dapat menyebabkan masalah mental emosional, salah satunya kecemasan. Kecemasan dapat diartikan sebagai keadaan tegang, perasaan tidak aman, dan khawatirakan suatu peristiwa yang tidak menyenangkan. Teknik relaksasi benson merupakan salah satu terapi komplementer untuk menurunkan ansietas. Dari hasil wawancara menyatakan kecemasan yang dialami dapat muncul ketika penyakitnya kambuh,diantara mereka ketika mengalami kecemasan dengan gejala merasa sulit tidur dan jantung yang berdegup kencang.Metode: Metode kegiatan pengabdian masyarakatini dilakukan dengan cara memberikan penyuluhan kesehatan dan latihan teknik relaksasi benson pada 27 lansia penderita hipertensi dengan kecemasan. Terapi benson sebagai salah satu terapi non farmakologi yang dapat dilakukan untuk menurunkan kecemasan.Hasil: Sebelum diberikan terapi benson tingkat ansietas yang dialami lansia memiliki nilai Mean = 9,9259, dan setelah pemberian diperoleh nilai Mean = 4,0370, diperoleh hasil p value = 0,000 (<0,05).Kesimpulan: Terdapat pengaruh yang signifikan pemberian terapi benson terhadap penurunan ansietas pada kelompok lansia dengan hipertensi.
Корреляционный анализ латентного видеопотока при управлении БАС от первого лица
Authors: А.А. Березкин , Н.А. Облаков , А.А. Ченский , Р.В. Киричек
Published: December 2024

Статья посвящена исследованию изменчивости тензоров латентных пространств признаков, которые получены из кадров видеопотока, снятых на камеру, расположенную на борту беспилотного воздушного судна. В работе проводится анализ динамики тензоров латентного пространства кадров видеопотока, получаемых с помощью модели VAE-VQ-f16 из состава моделей Stable Diffusion. Исследование включает в себя кластеризацию кадров, анализ изменчивости последовательных кадров с использованием косинусного расстояния, изучение корреляционных зависимостей в латентном пространстве и анализ автокорреляции видеопотока. Полученные результаты демонстрируют потенциальную возможность реализации моделей предсказания тензоров латентных пространств последующих кадров видеопотока при FPV-управлении беспилотными системами от первого лица.

This article is devoted to the study of the variability of tensors of latent feature spaces. The paper analyzes the dynamics of the latent space tensors of video stream frames obtained using the VAE-VQ-f16 model from the Stable Diffusion models. The study includes frame clustering, analysis of the variability of successive frames using the cosine distance, study of correlation dependencies in the latent space, and analysis of the autocorrelation of the video stream. The obtained results demonstrate the potential possibility of implementing models for predicting tensors of latent spaces of subsequent frames of a video stream in UAVs FPV control.
Educação Ambiental para o Desenvolvimento Humano na Educação Integral
Authors: Neves Prosdocimo Natacha Souza das
Published: November 2024

Este estudo aborda a contribuição da educação ambiental no desenvolvimento da formação humana em centros de educação integral municipal da rede de ensino de Curitiba. A reflexão trata sobre quais contribuições a educação ambiental pode fornecer para o desenvolvimento humano na educação integral em escolas municipais de Curitiba? Busca-se compreender a educação ambiental como prática social com intencionalidade articulada à educação integral em escolas municipais de Curitiba marcada por determinações externas e internas. As referências teóricas que fundamentam o estudo são: Souza (2016); Loureiro (2006; 2012; 2019); Guimarães (1995; 2004); Layrargues e Lima (2014); Sauvé (2005a, 2005b); Parente (2018) e Moll (2012; 2013). A pesquisa é de cunho qualitativa com dados de campo coletados em: documentos – leis, diretrizes curriculares nacionais, estaduais e municipais; Projeto Político-Pedagógico dos três Centros de Educação Integral pesquisados e, entrevistas com quatro professoras de Educação Ambiental destas locais de pesquisa situados na regional de Santa Felicidade em Curitiba. Severino (2016) foi adotado como referência para a análise interpretativa do conteúdo das entrevistas e na codificação e decodificação do conteúdo dos textos. Os resultados indicam que: a Educação Ambiental é regulamentada pelas políticas municipais na gestão escolar e as práticas pedagógicas dos professores; o espaço físico, gestão escolar, organização curricular e comunidade como eixos estruturantes da educação ambiental desempenham como determinações internas determinantes influências nas práticas pedagógicas dos professores dos Centro de Educação Integral pesquisados.  Constatou-se fragilidades nas práticas pedagógicas de Educação Ambiental destes professores, mas também, a presença de práticas pedagógicas por meio de projetos.
A Dimensão estética como componente na evolução da filosofia e da prática pedagógica nas Escolas da Infância em Reggio Emilia
Authors: Franco Marilene
Published: November 2024

Este artigo aborda a dimensão estética na construção de sentidos pela prática pedagógica na Educação Infantil, sob a ideia da polissemia da linguagem transcendente da estética como bela arte (HEGEL, 2001), relacionada com a produção do que é próprio da criança. Destaca-se a escola como um âmbito estético habitável (HOYUELOS, 2020), proveniente do pensamento de Loris Malaguzzi e sua pedagogia. Na abordagem Reggio Emilia, a arquitetura de suas escolas da infância considera as apropriações da criança sobre o espaço, como rede de relações em um âmbito escolar que forma um lugar qualificado de comunicação e aprendizagem dessas crianças. Assim, o objeto geral deste estudo é apresentar o espaço, em sua dimensão estética, como um fundamento da prática pedagógica nas escolas da infância de Reggio Emilia e seu papel educador no contexto da aprendizagem de crianças pequenas. As fontes bibliográficas que embasam este estudo são as obras de Hoyuelos (2020) e de Amaral Filho (2021). A elaboração deste artigo seguiu uma abordagem qualitativa e exploratória (CHIZZOTTI, 2017), baseando-se em uma análise temática de perspectiva indutiva. Com este estudo, desvela-se a dimensão estética como uma experiência encontrada nos espaços das escolas da infância em Reggio Emilia, que fundamenta uma prática pedagógica promotora de relações, liberdade, expressividade e aprendizagens sociais, afetivas e cognitivas de crianças pequenas.
 
Palavras-chave: Dimensão Estética. Espaço. Educação Infantil. Abordagem Reggio Emilia.
Selection of optimal technique for electrosurgical treatment of CIN
Authors:   Urals State Medical University, Yekaterinburg, Russia, Росюк Е. А. , Обоскалова Т. А. ,   Urals State Medical University, Yekaterinburg, Russia
Published: December 2024

The article presents the results of an experiment to determine the selection criteria for excisional
treatment of precancerous cervical diseases using electrosurgical instruments such as the loop electrode (LLETZ/excision) and the conization electrode (conization). The experiment took place in the training class of Fotek OOO (Yekaterinburg). A turkey filet was used as a dummy cervix. Excision was performed with three different electrodes, and conization was performed with two conization electrodes of different sizes, followed by a comparison of the sizes and shapes of the removed areas of biological tissue. In case a small-sized and low grade lesion on the cervix is more pronounced on the ectocervix, it is recommended to choose the loop electrode manufactured by Fotek OOO for excision (the electrode size during surgery is individual in each specific case). However, if severe lesions on the cervix primarily affect the endocervix (such as CIN 3), one should prefer the conization electrode.
TRANSFORMASI KREATIVITAS MELALUI EKSPLORASI PLASTISIN PADA ANAK USIA DINI DI TK AL-UBUDIYAH PAMEKASAN
Authors: Devi Kurnia Rahmawati  , Denok Dwi Anggraini
Published: November 2024

Penelitian ini bertujuan untuk mendeskripsikan pemanfaatan media plastisin dalam mengembangkan kreativitas anak usia dini kelompok A di TK Al-Ubudiyah Pamekasan. Jenis penelitian ini adalah kualitatif deskriptif. Teknik penelitian dilakukan melalui observasi partisipan, wawancara mendalam, dan studi dokumentasi selama satu semester pada tahun ajaran 2024/2025. Sumber data primer meliputi guru kelompok A, kepala sekolah, dan anak usia dini kelompok A, sementara data sekunder diperoleh dari dokumen-dokumen relevan seperti RPP dan hasil karya anak. Hasil penelitian menunjukkan bahwa pemanfaatan media plastisin memberikan dampak positif terhadap perkembangan kreativitas anak, meliputi aspek kelancaran, keluwesan, orisinalitas, dan elaborasi. Implementasi yang sistematis dan terintegrasi dalam kurikulum pembelajaran berhasil merangsang perkembangan berbagai dimensi kreativitas anak. Faktor pendukung keberhasilan program ini mencakup dukungan sekolah, antusiasme guru dan peserta didik, serta keterlibatan orang tua. Namun, ditemukan beberapa kendala seperti perbedaan kemampuan motorik halus antar anak dan keterbatasan waktu dalam beberapa sesi pembelajaran. Penelitian ini menyoroti pentingnya pendekatan individual dan fleksibel dalam penggunaan media plastisin, serta peningkatan kompetensi guru melalui pelatihan berkelanjutan untuk mengoptimalkan pengembangan kreativitas anak usia dini.
Kata Kunci: Anak Usia Dini, Kreativitas, Plastisin
PENGARUH PENGGUNAAN KURIKULUM MERDEKA DALAM PENGELOLAAN PENDIDIKAN DI RA AL-IKHLAS TASIKMALAYA
Authors: Siti Rahmawati  , Dewi Lara Anjangsari  , Wina Herliana  , Risbon Sianturi
Published: November 2024

Kurikulum merdeka khususnya di sekolah RA Al-Ikhlas sebenarnya bukan hal yang baru bagi guru,  juga banyaknya perubahan secara signifikan yang dirasakan oleh guru dalam pengimplementasian kurikulum merdeka ini terutama pada proses pembelajaran yang sekarang lebih banyak berpusat pada anak, sehingga kebutuhan anak lebih terprioritaskan, cara belajar anak juga yang lebih kooperatif banyak membuat anak tidak cepat bosan dalam pembelajaran, akan tetapi perubahan yang dirasakan guru untuk gurunya sendiri yaitu guru harus lebih banyak belajar lagi tentang teknologi ditengah keterbatasan kemampuan guru dalam penguasaannya, juga bagaimana harus lebih meningkatkan kekompakan guru dalam menjalankan kurikulum merdeka ini, sehingga harus banyak berkolaborasi dengan guru lain supaya bisa mencapai keberhasilan dalam implementasi kurikulum merdeka.  Tujuan dari dilakukannya penelitian ini untuk mengetahui pengaruh penggunaan kurikulum merdeka di RA Al-Ikhlas dalam pengelolaan pendidikan. Metode yang digunakan dalam penelitian ini ialah metode kalitatif yang dimana metode ini penelitian yang fokus pada pengamatan yang mendalam berdasarkan wawancara, observasi dan dokumentasi.
POLA ASUH ORANG TUA TERHADAP KOMUNIKASI SOSIAL ANAK USIA DINI DI KOBER AISYIYAH
Authors: Royani Hakim Syifa , Sianturi Risbon , Aulia Hidayati Zahra , Syifaurahmah Dewi
Published: November 2024

Tujuan dari penelitian ini adalah untuk menentukan bagaimana pola asuh orang tua mempengaruhi kemampuan komunikasi sosial anak-anak usia dini di KOBER Aisyiyah. Penelitian ini dilakukan pada bulan September hingga Oktober 2024. Metode ini menggunakan deskriptif kualitatif, dengan menyelidiki pola asuh orang tua terhadap komunikasi anak usia dini melalui wawancara, observasi, dan dokumentasi dari sepuluh orang tua. Hasil penelitian ini menunjukan bahwa cara orang tua mengasuh anak sangat mempengaruhi cara mereka berkomunikasi dan bersosialisasi. Anak-anak yang dibesarkan dalam lingkungan yang otoriter cenderung menjadi penurut, tetapi mereka sering merasa tidak percaya diri dalam berbicara dan lebih tertutup. Di sisi lain, anak-anak yang dibesarkan dalam lingkungan yang demokratis lebih mandiri, percaya diri, dan terbuka untuk berinteraksi dengan orang lain.
Spectral indicators of the post-pyrogenic state of steppe areas (using the example of a key territory in the Southern Trans-Urals)
Authors: Pavleichik Vladimir , Ryahov Roman
Published: December 2024

Pyrogenic effects are one of the most significant environmental and landscape-forming factors in the steppe regions of Northern Eurasia, and therefore the issues of assessing the nature and duration of restoration processes remain more than relevant. The objectives of the study were to identify regional features of the use of spectral indices in assessing the dynamics of postpyrogenic recovery processes. The key territory is located in the Southern Trans-Urals within the Orenburg Region and covers an area of 657 km2. In August 2017, part of it was exposed to fire. The initial materials were multispectral images of Landsat-8, the collection of zonal statistics was carried out on 26 sites with an area of 1 km2 each, linearly grouped into 6 conditional profiles. Taking into account the idea of the duration of post-pyrogenic recovery processes, the time series of images covers the growing season from 2016 to 2019. Widely used spectral indices were used for the analysis: NDVI, BAI, MIRBI, NBR, NBR2, NBRT1, NBRT3, SWVI and surface temperature. Based on the generated database, the values were calculated for individual profiles and for all sites in general, divided into burnt and unburnt territories. The actual (average, maximum and minimum) values and deviations from the benchmarks were calculated, tables of correlation dependencies between the values of spectral indices were prepared. All the considered spectral indices with varying degrees of contrast recorded the features of the burnt surface until the end of the growing season in 2017. MIRBI, NBR2 and surface temperature indicators showed the longest duration of preservation of differences between burning and natural vegetation without significant loss of contour boundaries (until the end of 2019). Some spectral indices (NDVI, NBR, NBRT1, BAI and, especially, SWVI) retained the outlines of the burning contour for a long time, but radically changed the nature of the relationship with the background at various times of the recovery period. This was facilitated by the active growth of green phytomass on the burns and the masking effect of dry phytomass on the control sites. The duration of the preservation of differences between burns and control areas according to remote sensing data is about two years (growing season). Approximately at the same time, the resumption of the ability to spread fire sustainably is estimated.
THE MODEL OF MOTIVATIONAL AND VALUE DETERMINATION OF THE FORMATION OF PROFESSIONAL COMPETENCES OF FUTURE HISTORY TEACHERS IN THE PROCESS OF STUDYING PROFESSIONAL DISCIPLINES
Authors: Koniakhin Yurii
Published: December 2024

This article describes developed model, that aimes at enabling the professional competencies of future history teachers through motivational and value-based determination. Within modern education, history teachers carry a dual responsibility: transmitting subject knowledge while cultivating civic-mindedness and critical thinking in students. The model addresses this challenge by integrating several methodological approaches, including competence, synergistic, systemic, activity-based, humanistic, and axiological. Each of these approaches contributes to a comprehensive model for teacher education. They emphasize not only the acquisition of historical knowledge but also the development of intrinsic motivation, ethical reasoning, and a commitment to fostering civic engagement in students. The model's components include a motivational and value component, which develops professional motivation and instills a strong civic sense of social responsibility in future teachers. The cognitive component enriches teachers' knowledge of history and cognitive processes, equipping them to engage students in critical inquiry and foster historical thinking. The methodological and pedagogical component focuses on practical teaching skills, such as classroom management, didactic interaction, and student assessment. Several pedagogical conditions are essential for effectively forming professional competencies. These include practice-oriented training, mentoring support, and reflective practice, which promote continuous professional growth through feedback and self-assessment. Interactive learning methods like role-playing, debates, and project-based learning foster critical engagement with historical content. The model performs multiple functions: cognitive, motivational, communicative, valuable, developmental, and educational, contributing to the holistic development of future history teachers. It prepares them to meet the intellectual and ethical demands of modern education. Specific training methods include moral analysis of historical events, reflective journaling, and critical evaluation of historical sources. The research identifies varying levels of competence formation: high, medium, and low, based on indicators such as civic position, critical thinking, and professional motivation. Teachers using the model show significant improvements in integrating historical knowledge with pedagogical strategies, fostering critical thinking, and promoting civic responsibility in students. The article concludes with practical implications of the model and recommends further research to explore its long-term effects on teaching practices and student outcomes.
Engineering Education in Nigeria: A Case Study of Mechanical Engineering
Authors: Sibete Godfrey Ayeabu , Waratimi EmomotimiObonika , Osaruchi Worgu Fortune
Published: November 2024

The paper examined the function of engineering
education in Nigeria, with special focus on
mechanical engineering. Engineering in our
institutions of higher learning have been designed
at training engineering manpower with theoretical
and practical knowledge and skill, for national
development: it highlighted the major function of
engineering education in nation building, the role
of mechanical engineers in developing nations,
current situations and problems of Engineering in
Nigeria, Mechanical Engineering components and
systems and its reliability. It is therefore deduced
that engineering education is a vital tool to national
development in Nigeria. It therefore recommended
that Engineering education should be effectively
and efficiently encourage by the government.
Broadcast Storm Mitigation Technique for Cluster Based (Bsmt_Cb) In Vanet
Authors: Aminu Muazu Abubakar , Musbahu Salisu
Published: November 2024

This research proposes a novel
clustering algorithm, Broadcast Storm Mitigation
Technique for Cluster Based (BSMT_CB) in VANET
(BSMT_CB), to address the broadcast storm problem
in VANETs. BSMT_CBeffectively groups vehicles
based on their relative mobility and selects a minimal
number of cluster heads and gateways to ensure
efficient message dissemination. By utilizing a
dominating set and set cover approach, the algorithm
achieves cluster stability and significantly reduces
redundant rebroadcasts.
Simulation results demonstrate the superior
performance of BSMT_CBin terms of message
delivery delay, packet loss ratio, packet delivery ratio,
and throughput. BSMT_CB outperforms existing
methods by reducing broadcast storms, enhancing
message reachability, and ensuring efficient message
dissemination even in dense traffic conditions. The
proposed algorithm offers a promising solution for
improving the efficiency and reliability of
communication in VANETs.
BIOLOGICALLY ACTIVE SUBSTANCES AND SORBENTS THAT INCREASE THE EFFECTIVENESS OF INDUSTRIAL AQUACULTURE
Authors:   Ulyanovsk state agrarian university named after P.A. Stolypin, Romanova Elena Mikhailovna , Romanov Vasily Vasilyevich ,   Ulyanovsk state agrarian university named after P.A. Stolypin, Lyubomirova Evgeniya Sergeevna ,   Ulyanovsk state agrarian university named after P.A. Stolypin, Sibgatullova Adylya Kamilevna ,   Ulyanovsk state agrarian university named after P.A. Stolypin, Lyubomirova Vaseline Nikolaevna ,   Ulyanovsk state agrarian university named after P.A. Stolypin
Published: November 2024

The article considers the prospects for using highly effective biologically active substances in industrial aquaculture that can increase its efficiency. Probiotics, vitamins, and amino acids were used as such substances, enhancing their effect with diatomites, natural sorbents. The goal was to evaluate the effect of such a complex of substances on productivity indicators, bacterial contamination of water, and the content of toxicants in the form of ammonia, nitrates, and nitrites. Biologically active substances were introduced into fish feed by irrigation, as well as by direct introduction into the water of fish-breeding modules. To conduct the research, control (n-30) and experimental groups of fish (n-30) were formed, kept in autonomous modules. The control group received basic feed, and the experimental group received feed enriched with biologically active substances and diatomite. Research of productivity indicators, microbiological and hydrochemical studies were conducted. The results of the work showed that the developed complex accelerates growth, increases productivity indicators, reduces bacterial contamination, and normalizes hydrochemical parameters in fish-breeding modules. Based on the obtained results, we came to the conclusion that in order to increase the efficiency of aquaculture, it is necessary to improve the ideology of feeding and keeping fish through the use of live microorganisms - probiotics, as well as vitamins and essential amino acids. Their presence is necessary for the formation of a healthy fish microbiome and protection against intestinal infections. In the complex we have developed, the effect of probiotics is enhanced by other biologically active substances: vitamins and amino acids, which in this context can be considered as metabiotics. The use of natural sorbents contributed to the reduction of bacterial contamination and toxic metabolites. The problem developed in the article is included in the number of "Priority areas for the development of science, technology and engineering in the Russian Federation".
KEPEMIMPINAN LURAH DALAM MENINGKATKAN KINERJA PEGAWAI DI KANTOR LURAH RAHANDOUNA KECAMATAN POASIA KOTA KENDARI
Authors: Sukadi  , Muhammad Ihsan Mattalitti  , Darwan Sari  , La Ode Abdul Harlan  , Wahyuddin  , Abdul Rahman
Published: November 2024

This study aims to analyze the leadership style of the Rahandouna Village Head in supporting the improvement of employee performance at the Rahandouna Village Office, Poasia District, Kendari City. The focus of the research is directed at four leadership indicators, namely as innovators, communicators, motivators, and controllers. The research method used is qualitative with data collection techniques through observation, in-depth interviews, and documentation. The results of the study show that the role of the Rahandouna Village Head as an innovator is not optimal. The lack of new ideas and innovations hinders improving creativity and work efficiency. On the contrary, as a communicator, the village head shows good communication skills, creating a harmonious and conducive working atmosphere. In the motivator aspect, the village head consistently encourages, and guidance, and emphasizes the importance of discipline, which supports the improvement of employee morale. However, in its role as a controller, the village head has not been effective, characterized by low supervision of employee performance and attendance, which harms work discipline.
KEBIJAKAN PEMERINTAH DAERAH TERHADAP PENANGANAN STANTING DI KABUPATEN HALMAHERA TIMUR
Authors: Mohbir Umasugi  , Ridho Harta  , Muhammad Darsan Hi Adam
Published: November 2024

This study is intended to explain how the stunting prevention policy for East Halmahera Regency with the highest stunting prevalence in North Maluku Province. This study also intends to find out how the policies are initiated by the local government and the relevance of their implementation in the community. This study uses a qualitative method with a descriptive approach. Data sources are obtained through interviews with relevant stakeholders. Data are processed through data collection, data analysis, and drawing conclusions and policy suggestions or recommendations. The results of the study show that the Central Halmahera Regency Local Government Policy in handling stunting is not optimal, as seen from the high stunting rate which places this district in first place in North Maluku in 2022. Interventions through anthropometric measurements are effective in increasing awareness of mothers and health cadres about the importance of nutritional status, while training in making PMT provides practical knowledge about healthy toddler menus. In the future, further counselling is needed on exclusive breastfeeding and complete basic immunization to support efforts to prevent stunting sustainably.
La literatura como herramienta para la enseñanza de la lexicografía en la conformación de corpus lingüísticos
Authors: Granados Reyes Nancy , González Ruiz Marijose
Published: December 2024

Este artículo parte del interés por la enseñanza del español en niveles superiores, destacando la importancia de la comprensión conceptual sobre el conocimiento puntual de contenidos. Por lo que se plantea utilizar la literatura como herramienta para el análisis lingüístico y cultural. Es una propuesta metodológica para la enseñanza de la lexicografía, específicamente para la conformación de corpus lingüísticos basados en la variación y cambio de significado de los verbos a partir de la literatura mexicana. Dicha propuesta se basa en emplear dos reconocidos métodos lexicográficos, el Curso de lexicología (2006) de Luis Fernando Lara y el Manual de técnica lexicográfica (2002) de José Álvaro Porto, para analizar un corpus de verbos hallados en obras literarias. Se ejemplifica con la obra El vampiro de la colonia Roma. Las aventuras, desventuras y sueños de Adonis García (1979), la cual contiene verbos con connotaciones sexuales propios de la comunidad homosexual y del contexto de la Ciudad de México (antes Distrito Federal) en los años setenta. En resumen, se busca profundizar en el análisis lingüístico de la obra literaria utilizando técnicas de lexicografía y recolección de datos contextualizados para comprender mejor el uso del lenguaje y su relación con la identidad y la cultura para coadyuvar de manera satisfactoria en la formación académica y profesional del estudiantado en letras hispanas y otras disciplinas afines.
La fuente hispano-latina del Vocabulario trilingüe español-latín-náhuatl (Newberry Library, Ayer, núm. 1478)
Authors: Esparza Torres Miguel Ángel
Published: December 2024

Este artículo aborda el problema de la datación de la fuente hispano-latina del Vocabulario trilingüe español-latín-náhuatl conservado en la Newberry Library de Chicago, ms. Colección Ayer, núm. 1478. El punto de vista que se adopta es el de situar este singular vocabulario en el contexto de desarrollo de la historia de la lingüística, es decir, considerándolo como un ensayo más de adaptación a otras lenguas de los vocabularios nebrisenses que, a partir de 1492 y c.1494, se van difundiendo y se van revisando, dando lugar a múltiples ediciones. En este artículo, primero, se ordena la información sobre las distintas ediciones del Vocabulario español-latino de Antonio de Nebrija, con una breve caracterización. A continuación, se demuestra que el ejemplar del vocabulario nebrisense que tenía delante el autor del trilingüe correspondía a una edición concreta de la conocida como secunda editio del Vocabulario español-latino: la de Sevilla 1516. Hay dos ediciones que llevan esa fecha: la auténtica y una contrahecha que, en realidad, es de 1520 en adelante, ambas por el mismo impresor. El texto de una y otra edición tienen diferencias que permiten determinar que la fuente es la edición auténtica de 1516 y no la contrahecha. A partir de la identificación de la fuente del Vocabulario trilingüe y de la fuente nebrisense del Vocabulario (1555) de Alonso de Molina, se hacen una serie de consideraciones sobre la posible datación del manuscrito y se dan razones para adelantar su datación, que podría estar entre 1530 y 1540.