bluuebunny/crossref_metadata_2025 huggingface dataset:
PENERAPAN TEKNOLOGI PENGOLAHAN TERASI UDANG BAGI USAHA KECIL MENENGAH DI KABUPATEN BANGKA SELATAN
Authors: Idiar Idiar , Rollastin Boy , Setya Pratama Muhammad , Erwansyah Erwansyah
Published: September 2022

Tanjung Ketapang Village is a centre for making shrimp paste in the South Bangka Regency. Shrimp paste is one of  the superior regional products with quality to be developed to compete in the global market. The stages of processing shrimp paste are drying, mixing salt and then fermentation, pounding shrimp, drying shrimp paste, pounding shrimp paste dough, and molding shrimp paste. The production stages are still carried out traditionally with manual equipment, which requires more energy and time and is less hygienic. The problems faced by the two partners are the production process which is still traditional and manual from beginning to the end of product processing, and conventional marketing systems. Based on problem,s analysis, data were obtained from the technical specifications of the machines needed by partners, namely mixing machines, grinding machines, and shrimp paste drying ovens. The implementation methods applied are identification of partner problems, machine design, machine manufacture and assembly, function testing, training on how to operate and maintain machines marketing management training, and mentoring for both partners. After the implementation of the partner's production process, namely an increase in the production capacity of shrimp paste for the two partners, it was twice as much as the previous production and online marketing media.
NYLON REINFORCEMENT CEMENT SHEET ON INDUSTRIAL BUILDING
Authors:   Dr J.J. Magdum College of Engineering, Hajare Amar Vilas
Published: September 2022

This paper investigated the study of Nylon Reinforced Cement sheets in civil engineering. Nylon has many exclusive properties that it makes suitable for combination with cement mortar. In this, nylon-reinforced cement sheet properties, nylon nets, specifications and construction procedures are studied. The purpose of this paper was to investigate the comparative study between sheets reinforced with nylon cement and regular asbestos sheeting. Because of its wide variety of unusual structures, nylon is excellent cement mortar additive. Nylon material has a high melting point, is chemically resistant, and is stable an alkaline area of mud. It also has a low price. In this process, nylon-reinforced cement sheets are cast, then under various tests, your results compared to those obtained using regular asbestos sheets. Nylon is a readily available non-reactive material that can be used in cement concrete as fiber amplification. This study shows a comparison of the effect of OPC and PCC as well as the use of nylon fiber on the improved durable condition, which was ultimately reflected in the lifetime of the structure. Have supplementary cementations materials, nylon-reinforced PCC exhibits better properties. In addition, electrical induction from the Rapid Chloride Penetration Test (RCPT) and chloride migration coefficient The Rapid Migration Test (RMT) is designed to obtain the optimum nylon fiber content.
STUDY ON AMBIENT AIR QUALITY AND EXCEEDANCE FACTOR FOR SOME CITIES OF HARYANA, INDIA
Authors:   MGCGV, Chitrakoot, Chaurasia Sadhana , Gupta Swatesh ,   MGCGV, Chitrakoot
Published: September 2022

This Study presents an analysis of the variation of concentration of air pollutants namely PM10, PM2.5, SOx and NO2 at some city of Haryana, in summer season. The results reveal that gaseous pollutants such as SOx and NO2 were within the permissible limits while particulate matter ware found higher than permissible NAAQS limit. Highest level of PM10(198.78 µg/m3 ) was found in month of June at Sonipat. It may pose detrimental effect on human and environmental health. In this study AQI and Exeedence factor was also calculated. The AQI for all the stations were found in moderate range (101-200). Exeedence factor for PM10 was found in critical range at all the sampling stations and for PM2.5itwas found in high pollution range at all stations except Panipat.
SALGIN DÖNEMİNDE SPOR BİLİMLERİ FAKÜLTESİ ÖĞRENCİLERİNİN UZAKTAN EĞİTİM DENEYİMLERİ
Authors: ULAŞ Mehmet , YILMAZ Aynur
Published: September 2022

Bu araştırmada, salgın döneminde spor bilimleri fakültesi öğrencilerinin uzaktan eğitim deneyimlerinin incelenmesi amaçlanmıştır. Araştırma, nitel araştırma yaklaşımlarından biri olan durum çalışması deseni kapsamında yürütülmüştür. Katılımcılar belirlenirken amaçlı örneklem yöntemlerinden ölçüt örnekleme tekniği kullanılmıştır. Bu kapsamda uzaktan eğitim sürecini deneyimleyen 19 spor bilimleri fakültesi öğrencisi araştırmaya dahil edilmiştir. Veriler yarı-yapılandırılmış görüşmeler ile elde edilmiştir. Verilerin çözümlenmesinde içerik analizi tekniği kullanılmıştır. Elde edilen bulgular; sürecin avantajları ve dezavantajları temaları altında incelenmiştir. Sürecin avantaj olarak deneyimlenmesinde uzaktan eğitimin hem zaman hem de ekonomik boyutta tasarruf sağlaması, derslere kolay ulaşım ve salgın sırasında derslerin devam ettirilmesi gibi faktörlerin rol oynadığı, dezavantaj olarak deneyimlenmesinde ise, uygulamalı bir alanda öğrenim gören katılımcıların uygulama derslerinin uzaktan yapılması ve karşılıklı etkileşim ortamının olmaması gibi faktörlerin rol oynadığı sonucu ortaya çıkmıştır. Araştırma sonuçlarına göre, alana özgü bir uzaktan eğitim uygulama kılavuzunun ve ileride salgın ve benzeri durumların tekrar yaşanma ihtimali düşünülerek uygulama derslerinin olumsuz etkilenmemesi için gerekli uzaktan eğitim modellerinin oluşturulması, bu dönemde yapılamayan uygulama dersleri için telafi programlarının fakülteler tarafından planlanması önerilebilir.
THE RESULTS OF REFORMS IN THE FIELD OF TRAINING HIGHLY QUALIFIED PERSONNEL IN THE LATE XX- EARLY XXI CENTURY: SCIENTIFIC PERSONNEL
Authors:   Ural Federal University named after the first President of Russia B. N. Yeltsin, Yekaterinburg, Russian Federation, ZAITSEVA EKATERINA , ZAPARIY VLADIMIR , ASRYAN GARRY ,   Military University. V. Sargsyan MO RA, Yerevan, Armenia
Published: September 2022

Aim - to study the last 25 yeas dynamics in the system of Russian postgraduate education. The research is based on institutional analysis of the system of postgraduate education, as well as the resource approach in assessing the human potential of scientific personnel, postgraduate students and doctoral students. A comparative approach allowed us to analyze the dynamics of changes in the numbers, gender, age characteristics of researchers, doctoral students and graduate students for the last decades. Other methods used include analysis and systematization of statistical data, periodization method, analysis of theoretical sources, secondary analysis of sociological data. Results: the article presents the overview of Russian postgraduate education system evolution and analyses characteristics of its present state. The authors introduce their own periodization of the postgraduate education system development. The study presents human capacity, age and gender profiles of scientific personnel. The study reveals the trend in reducing the number of organizations providing postgraduate studies, as well as the decrease in the number of postgraduate and doctoral students and researchers. The authors came to the conclusion that the present situation is characterized by the contradiction between government regulation to the system of postgraduate education and its possibilities to ensure these requirements. The crisis in the system of Russian postgraduate education is evident. The presented results evaluate the process of training highly qualified educational personnel, the effectiveness of the institute of postgraduate and doctoral studies, as well as the qualitative and quantitative characteristics of scientific personnel in Russia. The data presented in the article will contribute to the development of the state educational policy and bring the process of training highly qualified educational personnel in accordance with the requirements and demand for highly qualified specialists in modern industry and science.
A remark on the Riemann zeta function
Authors: Abe Yukitaka
Published: September 2022

We prove that if the number of nontrivial zeros of the Riemann zeta function which is not on the critical line is finite, then every nontrivial zero is on the critical line.
The Role of Positive Psychological Capital and Personality Traits on the Relationship of Conscious Awareness and Entrepreneurial Intention
Authors: VAIZ Tahir , EKEMEN Mehmet Ali
Published: September 2022

A conceptual model including conscious awareness, positive psychological capital, personality traits and entrepreneurial intention is suggested with the purpose of providing a deeper understanding on the premises of entrepreneurial intention. Data is gathered from students studying in North Cyprus universities for the purpose of testing the suggested model (n= 400). The gathered data is analysed with SPSS 23 and AMOS programmes. The findings of the analysis show that entrepreneurial intention is positively influenced by conscious awareness, positive psychological capital and personality traits. Moreover, it has been observed that positive psychological capital and personality traits play an intermediary role the effect of conscious awareness on entrepreneurial intention. The findings of the research can be of benefit for both researchers and practitioners. The present study not only provides information on entrepreneurial intention but also helps administrators to increase their awareness by presenting administrative recommendations.
The Loss of Indigenous Languages
Authors: Billings D.K.
Published: September 2022

How can someone lose his or her first language? How can a language disappear, leaving no speakers left who speak it? Why are indigenous languages disappearing? This paper considers the various ways that languages are lost and what it means to the native speakers. I will look at examples in Papua New Guinea and North and South America. I will also note the dilemmas of the multitude of migrants moving to new cultures and languages in the modern world.
Legal Struggles of the Indigenous Peoples of Guatemala
Authors: Phillips J.S.
Published: September 2022

Guatemala has a population of 17 million residents of which 41% are Maya; 1.77% are Xina people; 18% are of European descent; and 41% are of mixed indigenous and European ancestry. For several centuries the legacy of indigenous peoples in Guatemala has been under siege. There is overwhelming evidence that the indigenous peoples of Guatemala, in their history, have suffered from colonialism, economic imperialism, genocide, crimes against humanity, dispossession of their lands and resources, criminal gangs, and problems related to climate change. The above issues are examined within the framework of international law. International law and organizations could help to rescue their culture which will benefit all of humanity.
Национальные герои России в представлении учащихся школ и вузов Москвы, Санкт-Петербурга и Кировской области
Authors: Зыкина О.А.
Published: September 2022

Обращение к исторической памяти с целью выявления и анализа значимых для государственного строительства личностей позволяет, в том числе, судить о ключевых ориентирах, определяющих направления развития общества. За основу эмпирических данных были взяты результаты массового опроса, проведенного среди учащихся в Москве, Санкт-Петербурге и Кировской области в 2018–2019 гг. Одним из результатов текущего исследования стало создание списка персоналий, которых по мнению молодежи можно считать предметом гордости россиян. Среди названных героев в первую очередь упоминаются имена правителей российского государства с древности до наших дней – более половины респондентов отдает предпочтение именно этой категории деятелей. Относительно часто также звучат имена известных литераторов и военачальников. Столичная студенческая молодежь начинает обращать внимание на труд ученых и государственных деятелей, не обладающих наивысшими полномочиями. Сравнительный анализ ответов в зависимости от возрастной, гендерной, этнической и гражданской (включение себя в российскую общность) принадлежности учащихся свидетельствует о значимости этих параметров в ходе формирования исторической памяти и дает возможность показать ряд особенностей молодежного восприятия российской действительности.
An appeal to historical memory in order to identify and analyze personalities significant for state building allows, among other things, to judge the key landmarks that determine the directions of society's development. The empirical data are based on the results of a mass survey students in the Moscow and the Kirov region in 2018–2019. One of the results of the current research was the creation of a list of personalities that, in the opinion of young people, can be considered a source of pride for Russians. Among these heroes, the names of the rulers of the Russian state from antiquity to the present day are mentioned first of all – more than half of the respondents prefer this particular category of figures. Relatively often, the names of writers and military leaders are also mentioned. The metropolitan student youth is beginning to pay attention to scientific and government officials who do not have the highest authority. Comparative analysis of responses depending on the age, gender, ethnicity and civil (including oneself in the Russian community) affiliation of students indicates the importance of these parameters in the course of the formation of historical memory and makes it possible to show a number of features of the youth perception of Russian reality.
Приходские летописи как исторический источник о крестьянах Смоленской губернии
Authors: Пашкова И.В.
Published: September 2022

В статье рассматривается становление приходского летописания в Смоленской губернии в XIX веке, выявляются его характерные черты, такие как опора на опубликованные примеры, совмещение формализованной структуры и субъективной оценки авторов. На основе анализа приходских летописей Смоленской губернии, которые публиковались как историко‑статистические описания приходов, выстраивается образ смоленского крестьянина с точки зрения приходского священника. Существовало два устойчивых образа — великоруса и белоруса, которые отличались между собой характером, образом жизни и внешним видом, что связывалось с этнической принадлежностью. Священники пытались объяснить особенности характера и быта природными, социально-историческими и культурными особенностями. В целом образ крестьянина наделялся положительными чертами, такими как благоразумие, рассудительность, нищелюбие, но в то же время отмечалось существование суеверий, пороков (таких как пьянство, сквернословие, воровство), семейных разделов.
The article examines the tradition of writing parish chronicles in the Smolensk province in the 19th century and reveals its characteristic features, such as reliance on published examples, the combination of a formalized structure and authors’ subjective assessment. Based on the analysis of the parish chronicles, published as historical and statistical descriptions of parishes, the image of a Smolensk peasant from the point of view of a parish priest is reconstructed. There were two stable images — a Great Russian and a Belarusian differing in personality, lifestyle and appearance, which were associated with ethnicity. The priests explained these differences by natural, socio‑historical and cultural factors. In general, a peasant was seen as characterized by prudence, discretion and sympathy to the poor. At the same time, it was noted that superstitions, vices (such as drunkenness, foul language, theft), family breakdowns were common among them.
Роль учреждений культуры в национальной политике России: от прошлого к настоящему (на примере Республики Мордовия)
THE ROLE OF CULTURAL INSTITUTIONS IN RUSSIA’S NATIONAL POLICY: FROM PAST TO PRESENT (THE CASE OF THE REPUBLIC OF MORDOVIA)
Authors: Abduganiev N. N. , Nizamova L. I.
Published: September 2022

В статье рассматривается деятельность учреждений культуры в Республике Мордовия — библиотек, клубов, культурно‑досуговых центров (КДЦ) в советское время и на современном этапе. Сопоставляя такие разные по идеологическому содержанию этапы истории страны, авторы показывают схожую роль учреждений культуры в вопросах гармонизации межнациональных отношений и поддержания этнокультурного многообразия населения. Для описания советского периода авторы вводят в научный оборот статистические данные, материалы республиканских СМИ, в первую очередь публикации газеты «Красная Мордовия» (позднее «Советская Мордовия», ныне — «Известия Мордовии»), и архивные документы, хранящиеся в Центральном государственном архиве Республики Мордовия. При анализе многообразия современных культурно‑просветительских мероприятий, проводимых в республике, источниками послужили данные анкетных опросов экспертов и текущая документация учреждений культурного профиля. Авторы отмечают массовый охват в период СССР не только городского, но и сельского населения через систему клубов, библиотек, домов и дворцов культуры, кружковую деятельность, активность которых складывалась постепенно и особенно активизировалась с начала 1950‑хх гг. Как становится очевидным из данных исследования, современная работа культурно‑досуговых центров, библиотек и др. во многом опирается на опыт прошлого, но совершенствуется и развивается в условиях новых реалий.

The article examines the activities of cultural institutions in the Republic of Mordovia — libraries, clubs, and cultural and leisure centres (CLCs) during the Soviet period and at present. Comparing such ideologically different stages of the country’s history, the authors show how similar the role of cultural institutions is in harmonizing inter‑ethnic relations and maintaining ethno‑cultural diversity of the population. To describe the Soviet period, the authors introduce statistical data, materials from the republican media, mainly articles in the newspaper “Krasnaya Mordovia” (later “Soviet Mordovia”, now “Izvestia Mordovia”), and archival documents stored in the Central State Archive of the Republic of Mordovia. To analyze the diversity of contemporary cultural and educational activities in the republic, the authors used the questionnaire interviews with experts and current documentation of cultural institutions. The authors observe the mass involvement of not only urban, but also rural population in the USSR period, through the system of clubs, libraries, culture houses and palaces, which were developing gradually and became more popular from the beginning of 1950s. As the research data shows, the current work of cultural and leisure centres, libraries, etc. is largely based on the experience of the past, but is being improved and developed under the new realities.
Частные похороны в СССР: от инфраструктуры к низовому регулированию и практикам самообеспечения
PRIVATE FUNERALS IN THE SOVIET UNION: FROM INFRASTRUCTURE TO GRASSROOTS REGULATION AND SELF-SUPPLY PRACTICES
Authors: Sokolova A.D.
Published: September 2022

В статье показано как слом инфраструктуры похоронного обеспечения, произошедший в первые послереволюционные годы, привел к возникновению низовых похоронных практик. В статье описываются причины кризиса. На материалах источников личного происхождения и архивных данных показана реакция современников на трудности захоронения умерших, а также описывается возникновение практик самообеспечения, включаясь в которые родные и близкие умерших решали проблему отсутствия профессиональной помощи при погребении. Фактически основную ответственность за проведение похорон рядовых граждан вынуждены были взять на себя семьи умерших. На место похоронных бюро пришли кустари‑совместители, оказывавшие отдельные похоронные услуги, что было для них дополнительным заработком. Несмотря на то, что наиболее острые проявления похоронного кризиса сравнительно быстро исчезли, практики самообеспечения, возникшие в результате кризиса, закрепились и стали системными в более поздние периоды.
The article shows how the breakdown of the funeral infrastructure that occurred in the first post‑revolutionary years led to the emergence of grassroots funeral practices. The article describes the causes of the crisis. Based on materials from sources of personal origin and archival sources, the reaction of contemporaries to the difficulties of burying the dead is shown, as well as the emergence of grassroots funeral practices, including those where relatives and friends of the deceased solved the problem of lack of professional assistance during burial. In fact, the families of the deceased had to assume the main responsibility for providing funerals for ordinary citizens. Funeral homes were replaced by handicraftsmen who provided separate funeral services as a source of additional income. Although the most acute manifestations of the funeral crisis disappeared relatively quickly, the practices of self‑sufficiency that arose as a result of the crisis took hold and became systemic in later periods.
Selection of a suitable photosynthetically active microalgae strain for the co-cultivation with mammalian cells
Authors: Dani Sophie , Windisch Johannes , Valencia Guerrero Xally Montserrat , Bernhardt Anne , Gelinsky Michael , Krujatz Felix , Lode Anja
Published: September 2022

Preventing hypoxic zones in 3D bioprinted mammalian cell-laden constructs using an internal oxygen supply could enable a more successful cultivation both in vitro and in vivo. In this study, the suitability of green microalgae as photosynthetic oxygen generators within bioprinted constructs was evaluated by defining and investigating important parameters for a successful co-culture. First, we assessed the impact of light–necessary for photosynthesis–on two non-light adapted mammalian cell types and defined red-light illumination and a temperature of 37°C as essential factors in a co-culture. The four thermotolerant microalgae strains Chlorella sorokiniana, Coelastrella oocystiformis, Coelastrella striolata, and Scenedesmus sp. were cultured both in suspension culture and 3D bioprinted constructs to assess viability and photosynthetic activity under these defined co-culture conditions. Scenedesmus sp. proved to be performing best under red light and 37°C as well as immobilized in a bioprinted hydrogel based on alginate. Moreover, the presence of the antibiotic ampicillin and the organic carbon-source glucose, both required for mammalian cell cultures, had no impact on bioprinted Scenedesmus sp. cultures regarding growth, viability, and photosynthetic activity. This study is the first to investigate the influence of mammalian cell requirements on the metabolism and photosynthetic ability of different microalgal strains. In a co-culture, the strain Scenedesmus sp. could provide a stable oxygenation that ensures the functionality of the mammalian cells.
Composition design and characterization of alkali-activated Slag–Metakaolin materials
Authors: Zhan Jianghuai , Li Hongbo , Li Huang , Cheng Zhenyun , Fu Bo
Published: September 2022

This study explores the effects of the interactions among Na2O content, metakaolin content and activator modulus on the compressive strength and autogenous shrinkage of alkali-activated slag–metakaolin (AASM) materials. The Box–Behnken RSM design was used to create an experimental scheme, establish a model, and optimize the mix proportions. Fourier transform infrared spectroscopy, scanning electron microscopy, and Mercury intrusion experiments were used to analyze the compositions, microstructures, and pore structures of the hydration products of the AASM, respectively. Results showed that the interactions between the activator modulus and metakaolin content, as well as Na2O content and metakaolin content, are the key factors affecting the compressive strength and autogenous shrinkage, respectively, of the AASM. Under the optimal conditions of Na2O content of 6%, sodium silicate modulus of 1.5, and metakaolin/slag ratio of 1: 3, the relative errors in the model verification test for compressive strength and autogenous shrinkage are 0% and 0.18%, respectively. In the water glass modulus and metakaolin content interaction, Ca2+, A13+, and Si4+ ions in the composite system react with several [SiO4]4− groups to form C-A-S-H and N-A-S-H gels, which fill each other to make the composite structure denser. When Na2O interacts with metakaolin, the OH− and Na+ in the solution react with A13+ and Si4+ to generate additional N-A-S-H, thereby reducing the compressive strength of the composite system, mitigating autogenous shrinkage, and increasing volume stability.
Deep exploration of Jiaodong type gold deposit, taking Shanhou gold deposit, southern part of Zhaoping fault as an example
Authors: Xu Zhi-He , Ding Zheng-Jiang , Gu Guan-Wen , Jiang Ji-Yi , Wang Li , Niu Xing-Guo
Published: September 2022

Crustal response induced by the subduction of Paleo-Pacific Plate, is crucial to study the metallogenic law and prediction of Jiaodong type gold deposit. Gold deposits are preferentially hosted in the lithospheric-scale second-order faults, which provide migration channels, mineralization corridors, and the physicochemical conditions. Super-large gold deposits in northwestern Jiaobei Terrane are generally controlled by regional linear faults, such as Sansandao, Jiaojia, Zhaoping and Qixia faults. However, Zhaoping fault is exposed sporadically (in Xiadian and Jiangjiayao gold deposits) beneath a thick cover of Quaternary basalts, which indicating that limited information can be obtained by traditional geological survey. In this study, high-precision geophysical surveys such as gravity and controlled source audio frequency magnetotellurics (CSAMT) are conducted in the Shanhou gold deposit, which hosted in southern part of Zhaoping fault. Three integrated geophysical profiles results further identified the spatial distribution of second-order oblique-slip faults of Zhaoping fault and established the relationships between brittle deformation and mineralization. The spatial variability of stratum (high density 2.82 g/cm3 and intermediate to high specific resistivity 4000 Ω m), brittle-slip faults (intermediate density 2.73 g/cm3 and low specific resistivity 200 Ω m) and magmatite (low density 2.57 g/cm3 high specific resistivity 8000 Ω m) are identified by two inversion techniques, including the man-machine interactive inversion technology and nonlinear conjugate gradient technology. In addition, the geophysical inversion pseudo sections delicately portray a smooth-out waveform low specific resistivity anomaly, which strongly couples with the spatial ore-hosted locations and enrichment places. The gold mineralized alteration zones generally dips to southeast and the angle changing from 45° to 30°, which are strong coupling with the large-scale acid magmatic intrusion and extensional tectonics occurred in the late Mesozoic. Finally, according to the deep prospecting prediction, a gold ore body with 10 m in thickness was revealed by drilling below the depth of 1,015 m, which is hosting in the brittle deformation of Zhaoping fracture zone.
Performance analysis and modeling of bio-hydrogen recovery from agro-industrial wastewater
Authors: Safdar Hossain SK , Sadiq Ali Syed , Cheng Chin Kui , Ayodele Bamidele Victor
Published: September 2022

Significant volumes of wastewater are routinely generated during agro-industry processing, amounting to millions of tonnes annually. In line with the circular economy concept, there could be a possibility of simultaneously treating the wastewater and recovering bio-energy resources such as bio-hydrogen. This study aimed to model the effect of different process parameters that could influence wastewater treatment and bio-energy recovery from agro-industrial wastewaters. Three agro-industrial wastewaters from dairy, chicken processing, and palm oil mills were investigated. Eight data-driven machine learning algorithms namely linear support vector machine (LSVM), quadratic support vector machine (QSVM), cubic support vector machine (CSVM), fine Gaussian support vector machine (FGSVM), binary neural network (BNN), rotation quadratic Gaussian process regression (RQGPR), exponential quadratic Gaussian process regression (EQGPR) and exponential Gaussian process regression (EGPR) were employed for the modeling process. The datasets obtained from the three agro-industrial processes were employed to train and test the models. The LSVM, QSVM, and CSVM did not show an impressive performance as indicated by the coefficient of determination (R2) < 0.7 for the prediction of hydrogen produced from wastewaters using the three agro-industrial processes. The LSVM, QSVM, and CSVM models were also characterized by high prediction errors. Superior performance was displayed by FGSVM, BNN, RQGPR, EQGPR, and EQGPR models as indicated by the high R2 > 0.9, an indication of better predictability with minimized prediction errors as indicated by the low root mean square error (RMSE), mean square error (MSE), and mean absolute error (MAE).
An improved selective ensemble learning approach in enabling load classification considering base classifier redundancy and class imbalance
Authors: Wang Shiqian , Han Ding , Hua Yuanpeng , Wang Yuanyuan , Wang Lei , Liu Yang
Published: September 2022

In modern power systems, analyzing the behaviors of the end users can help to improve the system’s security, stability, and economy. Load classification provides an efficient way to implement awareness of the user’s behaviors. However, due to the development of data collection, transmission, and storage technologies, the volumes of the load data keep increasing. Meanwhile, the structure and knowledge hidden in the data become ever more complicated. Therefore, the parallelized ensemble learning method has been widely employed in recent load classification research. Although the positive performance of ensemble learning has been proven, two critical issues remain: class imbalance and base classifier redundancy. These issues raise challenges of improving the classification accuracy and saving computational resources. Therefore, to solve the issues, this article presents an improved selective ensemble learning approach to enable load classification considering base classifier redundancy and class imbalance. First, a Gaussian SMOTE based on density clustering (GSDC) is introduced to handle the class imbalance, which aims to achieve higher classification accuracy. Second, the classifier pruning strategy and the optimization strategy of the ensemble learning are further introduced to handle the base classifier redundancy. The experimental results indicate that when combined with the popular classifiers, the presented approach shows effectiveness for serving the load classification tasks.
Indexing coordination of ecosystem and urban economic vitality in coastal cities: An observation in yangtze river delta
Authors: Liu Xiaojing , Pan Yan , Zhou Haiyan
Published: September 2022

Advanced geographic technologies provide an opportunity to understand the urban forest landscape and guide the governance of the urban ecosystem. However, only few studies stressed the importance of data techniques in understanding urban sustainability, especially urban forest landscape. Therefore, this study makes an analysis of urban forest resources in a city of Yangtze River Delta with the help of multi-source data techniques and further data analysis of different forest landscape pattern indices in the study area with the help of SPSS (Statistical Product and Service Solutions). The following conclusions are drawn: 1) According to the visual analysis, the spatial distribution of forest patches in the study area has a great difference. 2) All the seven landscape pattern indices are positively correlated with the distribution density of POI (Point of Interest), which represents the urban economic vitality. The correlation coefficients are NP (R2 = 0.3063), PD (R2 = 0.0079), ED (R2 = 0.3955), AREA (R2 = 0.5408), CONTIG (R2 = 0.0323), PAFRAC (R2 = 0.3662) and AI (R2 = 0.2014), respectively. This indicates that the higher the economic vitality is, the more fragmented and complex the urban forest patches are. 3) According to the geographically weighted regression model, the goodness of fit between the spatial distribution density of POI and NP, PD, ED, and AI reaches 0.804, 0.771, 0.634, and 0.619, respectively, and the explanatory power of the model is more than twice that of the corresponding linear regression model. The data illustrates that the correlation between economic vitality and urban forest landscape pattern indices has significant spatial heterogeneity.
Node-place model extended by system support: Evaluation and classification of metro station areas in Tianfu new area of Chengdu
Authors: Ma Jiexi , Shen Zhongwei , Xie Yi , Liang Pengpeng , Yu Bingjie , Chen Li
Published: September 2022

The construction of new urban areas has become one of the important ways for urban regeneration throughout the process of polycentric urban development. New urban area construction following transit-oriented development (TOD) conception advocates development around the public transportation stations. To gain more benefits around the stations, it is necessary to conduct an ex-ante evaluation of TOD projects in the new urban area. The Node-place (NP) model is a commonly used method for TOD evaluation and classification, which essentially designs an analytical framework for assessing station areas in both transport (node) and land use (place) aspects. The objective of our study is twofold. First, based on the original NP model, we propose the node-place-system support (NPS) model by introducing a novel evaluation dimension—system support—which quantitatively describes the relationship between local stations and the overall urban system. Second, taking advantage of multi-sourced data and Geographical Information System (GIS) techniques, we employ the proposed NPS model to evaluate and classify the metro stations in the Tianfu New Area of Chengdu, China. The results show that most stations present a balanced relationship between transport and land use performances. However, for a fraction of these balanced stations, we observe a mismatch between the system support and NP performances. Accordingly, we identify the system-mismatched stations and provide targeted improvement strategies for urban design.
Regulatory pattern of abnormal promoter CpG island methylation in the glioblastoma multiforme classification
Authors: Wang Rendong , Zhao Lei , Wang Shijia , Zhao Xiaoxiao , Liang Chuanyu , Wang Pei , Li Dongguo
Published: September 2022

Glioblastoma (GBM) is characterized by extensive genetic and phenotypic heterogeneity. However, it remains unexplored primarily how CpG island methylation abnormalities in promoter mediate glioblastoma typing. First, we presented a multi-omics scale map between glioblastoma sample clusters constructed based on promoter CpG island (PCGI) methylation-driven genes, using datasets including methylation profiles, expression profiles, and single-cell sequencing data from multiple highly annotated public clinical cohorts. Second, we identified differences in the tumor microenvironment between the two glioblastoma sample clusters and resolved key signaling pathways between cell clusters at the single-cell level based on comprehensive comparative analyses to investigate the reasons for survival differences between two of these clusters. Finally, we developed a diagnostic map and a prediction model for glioblastoma, and compared theoretical differences of drug sensitivity between two glioblastoma sample clusters. In summary, this study established a classification system for dissecting promoter CpG island methylation heterogeneity in glioblastoma and provides a new perspective for the diagnosis and treatment of glioblastoma.
Simplified calculation method and stability analysis of top beam cooperative pile–anchor supporting slope structure
Authors: Ma Tianzhong , Zhu Yanpeng , Ye Shuaihua
Published: September 2022

Aiming at the problem of insufficient research on the action mechanism and stability calculation method of the top beam in the pile-anchor support structure, firstly the force and deformation model are established based on the elastic fulcrum method and the deformation coordination principle of the pile-anchor structure at the pile top and the anchor end in this paper. Secondly, the calculation model of the support structure under the synergy of the crown and beam and the simplified calculation method of the internal force, displacement and overall stability of the slope are constructed. Finally, combined with an engineering example, a MATLAB program was compiled for calculation, and the pile-anchor structures with crowned beams and without crowned beams were simulated and calculated by the finite element software PLAXIS 3D and Geo Studio. These three aspects are compared and verified. The results show that the internal force, deformation and minimum safety factor calculated by the method in this paper are basically consistent with the numerical simulation calculation results of the top beam condition; the existence of the top beam effectively enhances the bearing capacity of the pile body, and also restricts the displacement of the pile top development; the synergy of the crown and beam makes the safety factor of the slope increase significantly and improves the safety and stability of the slope. The research in this paper can provide a certain reference value for the theoretical calculation and design of the pile-anchor supported slope considering the top beam in engineering practice.
Non-lysine ubiquitylation: Doing things differently
Authors: Kelsall Ian R.
Published: September 2022

The post-translational modification of proteins with ubiquitin plays a central role in nearly all aspects of eukaryotic biology. Historically, studies have focused on the conjugation of ubiquitin to lysine residues in substrates, but it is now clear that ubiquitylation can also occur on cysteine, serine, and threonine residues, as well as on the N-terminal amino group of proteins. Paradigm-shifting reports of non-proteinaceous substrates have further extended the reach of ubiquitylation beyond the proteome to include intracellular lipids and sugars. Additionally, results from bacteria have revealed novel ways to ubiquitylate (and deubiquitylate) substrates without the need for any of the enzymatic components of the canonical ubiquitylation cascade. Focusing mainly upon recent findings, this review aims to outline the current understanding of non-lysine ubiquitylation and speculate upon the molecular mechanisms and physiological importance of this non-canonical modification.
Interactions of marine sulfated glycans with antithrombin and platelet factor 4
Authors: Zhang Wenjing , Jin Weihua , Pomin Vitor H. , Zhang Fuming , Linhardt Robert J.
Published: September 2022

The molecular interactions of sulfated glycans, such as heparin, with antithrombin (AT) and platelet factor 4 (PF4) are essential for certain biological events such as anticoagulation and heparin induced thrombocytopenia (HIT). In this study, a library including 84 sulfated glycans (polymers and oligomers) extracted from marine algae along with several animal-originated polysaccharides were subjected to a structure-activity relationship (SAR) study regarding their specific molecular interactions with AT and PF4 using surface plasmon resonance. In this SAR study, multiple characteristics were considered including different algal species, different methods of extraction, molecular weight, monosaccharide composition, sulfate content and pattern and branching vs. linear chains. These factors were found to influence the binding affinity of the studied glycans with AT. Many polysaccharides showed stronger binding than the low molecular weight heparin (e.g., enoxaparin). Fourteen polysaccharides with strong AT-binding affinities were selected to further investigate their binding affinity with PF4. Eleven of these polysaccharides showed strong binding to PF4. It was observed that the types of monosaccharides, molecular weight and branching are not very essential particularly when these polysaccharides are oversulfated. The sulfation levels and sulfation patterns are, on the other hand, the primary contribution to strong AT and PF4 interaction.
Case report: Application of non-VKA oral anticoagulants in patient of idiopathic hypereosinophilic syndrome with intracardiac thrombus
Authors: Zou Man , Liu Geyan , Li Yanhui
Published: September 2022

Idiopathic hypereosinophilic syndrome (IHES) is a rare but life-threatening disease related to a group of myeloproliferative disorders characterized by prolonged eosinophilia of unknown cause and inflammatory damage to multiple organs. Here, we present a 44-year-old female patient complaining of shortness of breath and palpitations for 1 month. Her history and presentation were unremarkable, except for a 3-years history of rheumatoid arthritis treated with ibuprofen (0.3 g per day). Initial examination showed heart rate (HR) 120 bpm, respiratory rate (RR) 20 bpm, temperature (T) 36°C, blood pressure (BP) 130/70 mmHg, ventricular gallop rhythm, rales at the lung bases, soft abdomen, nonpalpable liver and spleen, and slight edema in both lower extremities. Bone marrow aspirate and biopsy confirmed the diagnosis of IHES, while cardiac MRI showed intracardiac thrombus. The symptoms of shortness of breath and palpitation disappeared, the eosinophil counts in routine blood tests were normal, and the thrombus in the cardiac cavity gradually disappeared after combined therapy of anti-hypereosinophilic, anti-coagulant and anti-heart failure treatments.
A bibliometric research based on hotspots and frontier trends of denosumab
Authors: Ren Bolin , Ren Xiaolei , Wang Lu , Tu Chao , Zhang Wenchao , Liu Zhongyue , Qi Lin , Wan Lu , Pang Ke , Tao Cheng , Li Zhihong
Published: September 2022

Denosumab is a monoclonal antibody that targets and inhibits the osteoclast activating factor receptor activator for nuclear factor-κB ligand (RANKL). It has been widely used in the treatment of osteoporosis, giant cell tumors of bone, and in the prevention of malignant skeletal-related events (SREs). We collected the research results and related MeSH terms of denosumab from 2011 to 2021 through the Web of Science and PubMed, respectively. The literature was visualized and analyzed by CiteSpace and bibliometric online analysis platforms. The MeSH terms were biclustered using the Bibliographic Co-Occurrence Analysis System (BICOMB) and graph clustering toolkit (gCLUTO). The results show that the number of denosumab-related annual publications had increased from 51 to 215, with the United States leading and Amgen Inc. being the most influential in the past 10 years. Articles published in the Journal of Bone and Mineral Research had the highest total citations. Three scholars from Shinshu University in Matsumoto, Yukio Nakamura, Takako Suzuki, and Hiroyuki Kato, joined the field relatively late but produced the most. The clinical comparison and combination of denosumab with other drugs in the treatment of osteoporosis was the most significant focus of research. Drug withdrawal rebound and management strategies have gained more attention and controversy recently. MeSH analysis revealed eight major categories of research hotspots. Among them, exploring the multiple roles of the RANK-RANKL-OPG system in tumor progression, metastasis, and other diseases is the potential direction of future mechanism research. It is a valuable surgical topic to optimize the perioperative drug administration strategy for internal spinal fixation and orthopedic prosthesis implantation. Taken together, the advantages of denosumab were broad and cost-effective. However, there were still problems such as osteonecrosis of the jaw, severe hypocalcemia, a high recurrence rate of giant cells in the treatment of bone and individual sarcoidosis, and atypical femoral fractures, which need to be adequately solved.
EPM2A acts as a protective factor in prostate cancer, evidence from a real-world patient cohort
Authors: Ge Qintao , Li Jiawei , Tao Junyue , Gao Rui , Jin Chen , Zhou Jun , Zhang Meng , Hao Zongyao , Meng Jialin , Liang Chaozhao
Published: September 2022

EPM2A encodes a dual specificity phosphatase and has been proven to be a potential biomarker in several cancers but has not been mentioned in prostate cancer (PCA). We investigated the prognostic and therapeutic value of EPM2A in PCA. The TCGA-PRAD cohort was collected to evaluate the differential expression, prognostic value, immunocyte infiltration and drug sensitivity of EPM2A in PCA. We constructed a nomogram model to predict the recurrence probability for PCA patients. Immunohistochemistry was used to validate the different transcript levels of EPM2A between tumor and normal tissues. A real-world AHMU-PC cohort was employed for validation. The results showed decreased expression of EPM2A in 95.65% of tumor tissues and was related to their prognosis, especially PCA (p = 0.008, HR = 0.57, 95% CI: 0.371–0.863). Further multiple analysis by adjusting clinical features revealed that EPM2A acted as an independent prognostic factor (p = 0.014, HR = 0.589, 95% CI: 0.386–0.898). Pathway enrichment analysis showed variable signaling activation between high EPM2A expression patients (HEXP) and low EPM2A expression patients (LEXP). The HEXP group contained higher infiltration of immunocytes than the LEXP group, as well as high levels of PD-1, PD-L1 and PD-L2, while LEXP patients were more sensitive to cisplatin, paclitaxel and bicalutamide therapy. The nomogram containing the EPM2A group, T stage and Gleason score showed a preferable prognostic value (AUC = 0.755; Hosmer‒Lemeshow, p = 0.486). In validation, we confirmed the lower transcript level of EPM2A in PCA than in normal tissues (120.5 ± 2.159 vs. 138.3 ± 1.83, p = 0.035) and correlated it with the expression level of PD-1 (R = 0.283). Among the 66 patients from the AHMU-PC cohort, we further validated the function of EPM2A in PCA patients. HEXP patients had longer recurrence-free survival times (1207 ± 110 vs. 794.2 ± 97.02, p = 0.0063) and favorable prognoses (HR: 0.417, 95% CI: 0.195–0.894, p = 0.0245). Collectively, we identified the prognostic value of EPM2A in PCa via a bioinformatics method. Patients with higher EPM2A may be more sensitive to immunotherapy, and patients with lower EPM2A were more suitable for bicalutamide, cisplatin and paclitaxel therapy.
Neutrophil-to-platelet ratio predicts mortality following percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction
Authors: Lin Yuhui , Dai Wenjun , Chen Yongquan , He Xiaoqing , Xu Yunhong
Published: September 2022

This study aimed to evaluate the value of neutrophil-to-platelet ratio (NPR) in predicting all-cause mortality in patients with ST-elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PCI). We enrolled 186 patients with STEMI who underwent primary PCI in the Third Affiliated Hospital of Guangzhou Medical University between January 2017 and December 2018. Based on the NPR values, the patients were divided into two groups: the NPR >0.035 group (n = 82) and the NPR ≤0.035 group (n = 104). All-cause mortality of the patients was followed up for 3 years. By the end of 3 years, 109 (58.6%) patients survived, 53 (28.5%) died, and 24 (12.9%) were lost to follow-up. Univariate analyses found that NPR was associated with all-cause mortality (p < 0.05). In COX regression analyses, patients in the high NPR group had a higher risk of all-cause death than those in the low NPR group (HR = 2.296, 95% CI: 1.150–4.582). These results indicate that NPR could predict all-cause death in 3 years after primary PCI in patients STEMI. NPR values may be useful in risk stratification and in specifying individualized treatment in patients with STEMI. In addition, NPR is a low-cost and easily accessible indicator, if its strong predictive value is confirmed in further studies of other large populations, it can be introduced into clinical practice for effective application.