bluuebunny/crossref_metadata_2025 huggingface dataset:
To Replace or Not to Replace: What to do with the implantable cardioverter-defibrillator generator when the left ventricular function has improved
Authors: Adabag Selcuk , Hubers Scott
Published: May 2023

This editorial reviews the data to guide the discussion on whether or
not to replace implantable cardioverter-defibrillator generator when the
left ventricular ejection fraction has improved.
Embryonic development of parthenogenetic and sexual eggs in lower termites Running title Differences of parthenogenetic ability in two termite species
Authors: peng xin , khan zahid , Liu Xiaomin , deng shilin , fang gang , zhang min , Su Xiao-Hong , Xing Lianxi , Yan Rong
Published: May 2023

Termites are ancient social insects worldwide. In this research,
developmental stages of embryos in the sexual and parthenogenetic eggs
of Reticulitermes chinensis and R. aculabialis were observed and
categorized. The embryonic development eggs was decteted by DAPI
staining, single transcriptome sequencing analysis and RT-PCR . The
ovarian development of FF and FM groups in R. flaviceps occurred in the
early developmental stages, whilst in R. aculabialis, this occurred
mainly in the late developmental stage. The difference was significant
in micropyle number between the R. flaviceps FF colony type and the
R.aculabialis FF colony type. There were no significant differences in
the number of micropyles between other groups. In R. flaviceps, 86% of
unfertilized eggs stopped development during the formation of the
blastoderm, with the yolk cell gathering extensively at the egg center.
Single-cell transcriptome sequencing analysis were annotated many genes
in this two species termite. According this answer we analyzed the
egg-to-larvae genes expression, and found that the expression levels of
PKA, MAP2K1, MAPK1/3, HGK, MKP and Pax6 gene in RaFF were significantly
higher than RfFF (P<0.05). We found a significantly lower
oocyte cleavage rate in R. flaviceps than in R. aculabialis, resulting
in fewer developed oocytes in R. flaviceps. In both species, activation
and one or two cleavage events of oocytes occurred during ovulation, but
in R. flaviceps the development of unfertilized eggs stopped. We suggest
that genes with significant expression differences may play an important
role in oocyte and embryonic development in termites.
Assessment of the potential value of plasma Torque Teno virus DNA load monitoring to predict Cytomegalovirus DNAemia in patients with hematological malignancies treated with small molecule inhibitors: A proof-of-concept study
Authors: Navarro David , Asunción Carlos de la , Giménez Estela , Hernández-Boluda Juan , Terol María José , Albert Eliseo , López Javier , García-Gutiérrez Valentín , Andreu Rafael , Malo María Dolores García , Fox María Laura , Remigia María , Amat Paula , Solano Carlos
Published: May 2023

Background: It is unknown whether Torque Teno virus (TTV) DNA
load monitoring could anticipate the development of infectious events in
hematological patients undergoing treatment with small molecular
targeting agents. We characterized the kinetics of plasma TTV DNA in
patients treated with ibrutinib or ruxolitinib and assessed whether TTV
DNA load monitoring could predict the occurrence of Cytomegalovirus
(CMV) DNAemia or the magnitude of CMV-specific T-cell responses.
Methods: Multicenter, retrospective, observational study,
recruiting 20 patients treated with ibrutinib and 21 with ruxolitinib.
Plasma TTV and CMV DNA loads were quantified by real-time PCR at
baseline and days +15, +30, +45, +60, +75, +90, +120, +150, and +180
after treatment inception. Enumeration of CMV-specific IFN-γ-producing
CD8 and CD4 T cells in whole
blood was performed by flow cytometry. Results: Median TTV DNA
load in ibrutinib-treated patients increased significantly (
P=0.025) from baseline (median, 5.76 log
copies/ml) to day +120 (median, 7.83 log copies/ml).
A moderate inverse correlation (Rho=-0.46; P<0.001) was
found between TTV DNA load and absolute lymphocyte count (ALC). In
ruxolitinib-treated patients, TTV DNA load quantified at baseline was
not significantly different from that measured after treatment inception
( P ≥0.12). TTV DNA loads were not predictive of the subsequent
occurrence of CMV DNAemia in either patient group. No correlation was
observed between TTV DNA loads and CMV-specific IFN-γ-producing CD8
and CD4 T cell counts in either
patient group. Conclusion: The data did not support the
hypothesis that TTV DNA load monitoring in hematological patients
treated with ibrutinib or ruxolitinib could be useful to predict either
the occurrence of CMV DNAemia or the level of CMV-specific
reconstitution.
Environmental Drivers of Genetic Variability in common Diatom Genera: Implications for Shallow Lake Biomonitoring
Authors: Ramos María Borrego , Rimet Frédéric , Bécares Eloy , Blanco Saúl
Published: May 2023

Diatoms are microalgae, known to present several characteristics that
make them excellent bioindicators. In this study, we analyzed the
epiphytic diatom communities of shallow lakes, with the aim of exploring
the genetic variability explained by physical, chemical or geographical
variables. We selected 77 lakes within the Spanish part of the Duero
River Basin characterized by wide chemical variability. In each lake,
physical parameters were measured in situ and water samples were taken
to determine nutrient levels in the laboratory. Diatom communities were
collected and identified by both microscopy and DNA-metabarcoding,
amplifying a genetic barcode of rbcL gene. We analyzed the phylogenetic
signal for several environmental parameters at the genus level for the
three most representative genera of these lakes. Our results indicate
significant phylogenetic signals that differ from a genus to another.
Processes related to spatial scales appear to be the main predictors
controlling the genetic diversity of diatom communities in these ponds,
with genetic variants deffering among geographical areas for a given
species. These molecular studies confirm the enormous diversity present
in the diatom communities that inhabit these ecosystems, but further
research is needed to apply diatom-based techniques in shallow lakes
monitoring or conservation programs. Our results reinforce the view that
considering not only morphological but also molecular and ecological
characters is necessary to describe new diatom species, especially given
the high number of species described each year.
Multi-dimensional health indices in India: A review of literature
Authors: Seghal Meena , Jatrana Santosh , Johnson Louise , Mathur Ritu
Published: May 2023

The composite indices have been widely used in different fields and
different settings to measure and quantify a variety of multidimensional
and complex concepts into a single construct. While many composite
health indices are produced and applied in developed countries, there
are relatively few studies for developing countries, and even
considerably less in Asia. However, the indicators of health relevant in
high-income countries will not be suitable for use in developing
countries such as India due to differences in health system
characteristics, differences in disease patterns, and data availability
and quality. Therefore, it is important to consider the specific context
and characteristics of a country when developing a composite health
index to ensure its relevance and usefulness for policy and
decision-making. In this paper, we review published studies on the
multidimensional composite health indices in India, specifically
focussing on the purpose of the index, the indicators chosen to
represent population health, methods used in the calculation of the
indices, geographical level of aggregation, sources of data, the
application and validation of index. While doing so, we also assessed
the policy or practical relevance of such indices.
Melatonin acts synergistically with pazopanib against renal cell carcinoma cells through p38 mitogen-activated protein kinase-mediated mitochondrial and autophagic apoptosis
Authors: Lai Chien-Pin , Chen Yong-Syuan , Ying Tsung-Ho , Kao Cheng-Yen , Chiou Hui-Ling , Kao Shao-Hsuan , Hsieh Yi-Hsien
Published: May 2023

Background: Mounting evidence indicates that melatonin has possible activity against different tumors. Pazopanib is an anticancer drug used to treat renal cell carcinoma (RCC). This study tested the anticancer activity of melatonin combined with pazopanib on RCC cells and explored the underlying mechanistic pathways of its action. Methods: The 786-O and A-498 human RCC cell lines were used as cell models. Cell viability and tumorigenesis were detected with the MTT and colony formation assays, respectively. Apoptosis and autophagy were assessed using TUNEL, annexin V/propidium iodide, and acridine orange staining with flow cytometry. The expression of cellular signaling proteins was investigated with western blotting. The in vivo growth of tumors derived from RCC cells was evaluated using a xenograft mouse model. Results: Together, melatonin and pazopanib reduced cell viability and colony formation and promoted the apoptosis of RCC cells. Furthermore, the combination of melatonin and pazopanib triggered more mitochondrial, caspase-mediated, and LC3-II-mediated autophagic apoptosis than melatonin or pazopanib alone. The combination also induced higher activation of the p38 mitogen-activated protein kinase (p38MAPK) in the promotion of autophagy and apoptosis by RCC cells than melatonin or pazopanib alone. Finally, tumor xenograft experiments confirmed that melatonin and pazopanib cooperatively inhibited RCC growth in vivo and predicted a possible interaction between melatonin/pazopanib and LC3-II. Conclusion: The combination of melatonin and pazopanib inhibits the growth of RCC cells by inducing p38MAPK-mediated mitochondrial and autophagic apoptosis. Therefore, melatonin might be a potential adjuvant that could act synergistically with pazopanib for RCC treatment.
The Use of Strategic Public Relations Communication Techniques inCampaigns to Raise Awareness of Breast Cancer: A Case Study of Breast Cancer Campaigns in Saudi Arabian Charities
Authors:   , Aldakhil Dalal
Published: May 2023

This study investigates the efforts of cancer charities in the Kingdom of Saudi Arabia to raise awareness of breast cancer through communication campaign techniques in order to reduce its incidence, which has been rising in the Saudi population for several years. Applying the Diffusion of Innovations Theory of Rogers (2003) as a theoretical framework, qualitative primary data was collected through semi-structured interviews with 12 individuals working in public relations (PR) and communications practice at six cancer charities to understand their experience of designing and planning health communication strategies to bring about health-related behavioural change among Saudi women. The study also involved qualitative content analysis of the Twitter pages of the six charities during Breast Cancer Awareness Month (October) in 2018 to determine communicative functions in accordance with the classification scheme of Lovejoy and Saxton (2012). The interview data revealed that not all of the charities employed dedicated PR practitioners in their communication departments, but all carried out some PR functions, with a significant emphasis on the technical rather than managerial roles of PR. The participants were found to use various communication strategies and methods to reach different target audiences. However, considerable difficulty was experienced in the design of specific campaign planning strategies, with the participants demonstrating little use of breast cancer campaign strategy to overcome the lack of knowledge and awareness among Saudi women. The study confirmed that the charities did not use Twitter strategically, employing the platform largely as a one-way channel of information communication. Additionally, the charities rarely used promotional and mobilising messages as an action function and did not follow the commonly accepted relationship-building strategies such as dialogic and two-way communication.
Sravnenie onkoliticheskoj aktivnosti rekombinantnyh shtammov virusa ospovakciny LIVP-RFP i MVA-RFP v otnoshenii solidnyh opuholej
Authors: Шакиба Я. , Набережная Е. Р. , Кочетков Д. В. , Юсубалиева Г. М. , Воробьев П. О. , Чумаков П. М. , Баклаушев В. П. , Липатова А. В.
Published: May 2023

Sredi onkoliticheskih virusov odnim iz naibolee izuchennyh yavlyaetsya virus ospovakciny (VV), shtamma modificirovannogo vysokoattenuirovannogo virusa Ankara (MVA), pokazavshego mnogoobeshchayushchie rezul'taty v doklinicheskih i klinicheskih ispytaniyah. SHtamm Lister VV iz Moskovskogo Instituta virusnyh preparatov (LIVP) issledovan v men'shej stepeni, chem MVA i imeet otlichnyj ot MVA tropizm. Cel'yu raboty bylo sravnit' onkoliticheskuyu effektivnost' shtammov LIVP i MVA v otnoshenii solidnyh opuholej. Dlya povysheniya selektivnosti LIVP i MVA k opuholevym kletkam nami byli polucheny rekombinantnye varianty s inaktivaciej gena timidinkinazy (TK), MVA-RFP i LIVP-RFP, ekspressiruyushchie krasnyj fluorescentnyj belok. Kinetiku replikacii i onkoliticheskuyu aktivnost' poluchennyh rekombinantnyh shtammov ocenivali in vitro i in vivo na liniyah opuholevyh kletok i allotransplantatah myshinyh singennyh modelej metastaticheskoj adenokarcinomy molochnoj zhelezy myshi 4T1, adenokarcinomy tolstoj kishki CT26 i melanomy B16. Kak MVA-RFP, tak i LIVP-RFP pokazali vysokuyu effektivnost' replikacii v opuholevyh kletkah i vyrazhennuyu onkoliticheskuyu aktivnost' v otnoshenii allotransplantatov melanomy V16 i adenokarcinomy molochnoj zhelezy 4T1. V otnoshenii 4T1, yavlyayushchejsya model'yu trojnogo negativnogo raka molochnoj zhelezy cheloveka, LIVP-RFP po sravneniyu s MVA-RFP pokazal bolee chem na 50% povyshennuyu citotoksichnost' v testah in vitro, a takzhe dostovernoe zamedlenie progressirovaniya allotransplantatov 4T1 i povyshenie vyzhivaemosti zhivotnyh v eksperimentah in vivo. Primenenie shtamma LIVP v kachestve platformy pri razrabotke rekombinantnyh onkoliticheskih virusov dlya terapii raka molochnoj zhelezy mozhet byt' bolee perspektivnym, chem primenenie shtamma MVA.
DAMPAK TRAUMATIS REMAJA KORBAN TINDAKAN KEKERASAN SEKSUAL SERTA PERAN DUKUNGAN SOSIAL KELUARGA
Authors: Ramadhani Salsabila Rizky , Nurwati R Nunung
Published: May 2023

Banyaknya pemberitaan mengenai kasus kekerasan seksual khususnya pada remaja sangat mengguncang hati nurani setiap orang karena remaja usia sekolah merupakan kelompok yang rentan dan memiliki tingkat ketergantungan yang tinggi pada orang dewasa. Kekerasan seksual terhadap remaja di samping berdampak secara fisiknya seperti masalah kesehatan, dampak secara psikis juga akan dialami korban seperti stres dan traumatis. Dampak yang muncul dari kekerasan seksual kemungkinan adalah depresi, fobia, dan mimpi buruk, curiga terhadap orang lain dalam waktu yang cukup lama. Tujuan yang hendak dicapai dalam penelitian ini adalah untuk mendeskripsikan seberapa besar dampak yang dialami korban kekerasan seksual dan bagaimana dukungan sosial keluarga dapat membantu korban untuk mengembalikan kepercayaan dirinya sehingga dapat berfungsi kembali secara sosial. Dalam penulisan artikel ini menggunakan metode deskriptif kualitatif. Hasil dari kajian ini menemukan; setelah korban mengalami kekerasan seksual dapat mengalami Post Traumatic Stress Disorder (PTSD). Keberadaan dan peran serta keluarga khususnya orang tua (bukan pelaku kekerasan) sangat penting dalam membantu anak dalam proses memulihkan diri dan penyesuaian pasca mengalami kekerasan seksual, seperti dukungan sosial yang diberikan oleh keluarga dapat berdampak besar pada proses pemulihan anak korban kekerasan seksual seperti dukungan sosial dan emosional, meningkatkan komunikasi dengan anak, keterlibatan orang tua terhadap proses penanganan kekerasan seksual yang dialami anak, dan sebagainya. The number of reports regarding cases of sexual violence, especially among teenagers, has shaken everyone's conscience because school-age teenagers are a vulnerable group and have a high level of dependence on adults. Sexual violence against teenagers in addition to having a physical impact such as health problems, psychological impacts will also be experienced by victims such as stress and trauma. The impact that arises from sexual violence may be depression, phobias, and nightmares, suspicious of others for a long time. The objectives to be achieved in this study are to describe how big the impact experienced by victims of sexual violence and how family social support can help victims to restore their self-confidence so that they can function again socially. In writing this article using a qualitative descriptive method. The handling and healing of psychological trauma due to sexual violence needs special attention such as the social support provided by the family can have a major impact on the recovery process of children victims of sexual violence such as social and emotional support, improving communication with children, parental involvement in the process of handling sexual violence experienced by children, etc.
Budidaya tanaman selada (Lactuca sativa L.) secara hidroponik dengan sistem DFT di BBPP Batangkaluku
Authors: Zahra Najmatul , Muthiadin Cut , Ferial Ferial
Published: May 2023

Hidroponik adalah metode budidaya tanaman dengan menggunakan media tanpa tanah (Soilless culture), seperti air, kerikil, pasir, material lain, salah satu metode hidroponik yaitu sistem DFT. Sistem DFT (Deep Flow Technique) memiliki prinsip yaitu aliran air masuk ke dalam pipa melalui pompa secara terus menerus. Salah satu jenis tanaman yang dapat dibudidayakan secara hidroponik ialah tanaman selada (Lactuca sativa L.). Selada merupakan tanaman yang dapat tumbuh di daerah dingin maupun tropis serta memiliki nilai ekonomis yang cukup tinggi. Tujuan penelitian ini adalah untuk mengetahui teknik membudidayakan tanaman selada secara hidroponik dengan sistem DFT bertingkat dengan penambahan nutrisi AB mix di Balai Besar Pelatihan Pertanian (BBPP) Batangkaluku. Metode penelitian yaitu dengan penanaman selada secara hidroponik dengan sistem DFT dan dilakukan pengamatan tinggi tanaman, jumlah daun, serta panjang akar dari hari ke-4 hingga hari ke-16 setelah pengaplikasian AB mix. Hasil penelitian menunjukkan bahwa pengaplikasian nutrisi AB mix berpengaruh dalam meningkatkan pertumbuhan tanaman selada yang dibudidayakan secara hidroponik dengan sistem DFT.
Sustainable Business Development Via Applying an Online Business Model for Gaining Benefit in Economics, Education, and Social Network
Authors: Purnomo Rochmat Aldy , Malynka Oksana , Prananto Adi
Published: May 2023

Regional  development  includes  infrastructure  and  information technology.  Infrastructure,  Information  and  Communication Technology  (ICT)  is  worse  in  rural  areas  and  small  towns  in Indonesia. One of such areas is the village of Menowo located in Magelang, Central Java Province, Indonesia. The purpose of this research is to study a contemporary phenomenon of  the Blogger Village within its real-life content. In this research, a case study is described: a young man who was born in the village has started an “online  business  community”.  Now,  people  call  the  Village Menowo “The Blogger Village”. Since 2014, more than 50 people in  the  Blogger  Village  have  got  their  own  revenue  accounts  for hundreds  of  thousands  of  U.S.  dollars  per  month.  The  Blogger Community  has  contributed  to  reducing  unemployment  in  the village.  The  study  has  found  that  the  Blogger  Community  can provide  additional  income  for  Magelang  SMEs.  Magelang  SMEs can use the profit margin of their businesses to update hardware and  software  including  Internet  information  sources  from anywhere.  The  study  provides  new  information  related  to  the regional  development,  local  development,  and  complement economic  empirical  studies  of  a  research  that  has  been  done before.  The  applied  research  is  beneficial  for  the  Government  of Magelang  to  determine  and  develop  policies  of  the  regional economic development of Magelang and to establish appropriate programs  and  activities  for  developing  the  economy  of  the  area. The  research  will  also  help  eliminate  the  overlap  among  the existing  rules  both  at  central  and  local  levels,  as  well  as  among sectors and agencies.
"Revolution and design. Discussions around social processes of transformation that lead to design"
Authors:   ", Caballero Quiroz Aarón José ,   UNIVERSIDAD AUTÓNOMA METROPOLITANA UNIDAD CUAJIMALPA", Mosqueda Gómez Claudia , López Pérez Blanca Estela , Bedolla Pereda Deyanira , Ortega Ibarra Carlos , López León Ricardo Arturo , Leidenberger Georg
Published: May 2023

This book is the result of the research project "Attempt of an epistemology from design", whose primary objective was the construction of a theoretical apparatus that would establish the conceptual bases for the characterization precisely of an epistemology concomitant to design. It is the product of the participation of different researchers in a seminar convened to reflect theoretically on design, as an activity that results from the emerging and shaping social processes of nations and is directed, mainly, to researchers, as well as interested not only in design and its historical contextualization, but also in those disciplines that analyze the characterization of social, political, and historical processes.
KDM3A, a Novel Blood-Based Biomarker in Colorectal Carcinogenesis
Authors: Polat D. , Onur E. , Yılmaz N. , Sökücü M. , Gerçeker O.F.
Published: May 2023

Colorectal cancer (CRC) is one of the leading causes of cancer-linked deaths globally. The determination of biomarkers is important in the prognosis and treatment of CRC. Previous studies emphasized the relationship between hypoxia and CRC in humans, and there is strong evidence that this process is strongly related to HIF-1. KDM3A is a histone demethylase that could directly bind to HIF-1α, a subunit of HIF-1. This study aimed to reveal whether the expression level of the KDM3A gene could be used as a predictor of CRC. The expression levels of HIF-1α, KDM3A, and Epithelial-Mesenchymal Transition (EMT) genes were evaluated by qRT-PCR in leukocyte samples of 50 CRC patients in different stages and 50 healthy controls. HIF-1α and KDM3A expression levels were significantly higher in the CRC group, compared to the controls. Slug and ZEB-1 genes, the mesenchymal markers, showed the same significance pattern between groups. We acquired 0.664 AUC with 54% sensitivity and 85.4% specificity for separating controls from CRC patients by using the KDM3A expression levels in ROC analysis. This data support that KDM3A could be a novel supplementary biomarker in diagnosis of CRC, which could be noninvasively detected in circulation.
Unusual Manifestation of Extraosseous Ewing Sarcoma: Report of 3 Cases
Authors: Ioannidou M. , Tsotridou E. , Samoladas E. , Tragiannidis A. , Kouskouras K. , Sfougaris D. , Spyridakis I. , Foroulis C. , Galli-Tsinopoulou A. , Hatzipantelis E.
Published: May 2023

Ewing sarcoma (ES), described as a diffuse endothelioma of the bone, is divided into two categories: osseous and extraosseous, which mainly affects adolescents. Extraosseous Ewing Sarcomas (EES) are rare tumors originating from soft tissues. Their clinical presentation depends mainly on the primary location of the tumor and are highly chemosensitive and radiosensitive. The purpose of this study was to describe the clinical characteristics and outcomes of 3 children with EES and uncommon presentation treated in our Unit. The diagnosis of EES was confirmed by biopsy and cytogenetic analysis with fluorescence in situ hybridization (FISH). Surgical excision was planned as primary treatment, followed by adjuvant chemotherapy according to EURO-E.W.I.N.G protocol. To date, all patients are alive, 1, 3 and 4 years after completion of treatment, with no signs of recurrence or metastasis.
BRCA 1/BRCA 2 Pathogenic/Likely Pathogenic Variant Patients with Breast, Ovarian, and Other Cancers
Authors: Osman K. , Ahmet K. , Hilmi T. , İlker N.O. , Ercan Ö. , Devrim Ç. , Murat S. , Emre Ç. , İlhan H. , Mustafa G. , Yüksel Ü. , Bahiddin Y. , Cihan E. , Mehmet Ali N. Ş. , Emrah E. , Umut D. , Zeynep O. , Mehmet Ali K. , Ali G. , İvo G. , Erkan Ö. , Muhammet B.H. , Bülent E. , Selma D. , Sernaz U. , Mahmut G. , Hakan G. , İrfan Ç.
Published: May 2023

The demographic and clinical characteristics of patients who have BRCA 1/BRCA 2 pathogenic/likely pathogenic variants may differ from their relatives who had BRCA-related cancer. In this study, we aimed to demonstrate the clinical and demographic findings of patients who had BRCA-related cancer and to assess the differences comparing their relatives who had BRCA-related cancer with breast, genital tract, prostate, and pancreas cancers as well. The results of sequencing analysis of 200 cancer patients (190 women, 10 men) who have been directed to genetic counseling with an indication of BRCA1/BRCA2 testing from different regions across 9 medical oncology centers were retrospectively analyzed. A total of 200 consecutive cancer patients who harbored the BRCA1/BRCA2 pathogenic/likely pathogenic variant (130 (65%) patients harbored BRCA 1 pathogenic/likely pathogenic variant, and 70 harbored BRCA 2 pathogenic/likely pathogenic variant) were included. Of these, 64.0% had breast cancer (43.8% of them had the triple-negative disease, and about 2.3% had only the HER-2 mutant), 31.5% had genital cancers (92.1% of them had ovarian cancer, 3.2% had endometrium, and 1.6% had peritoneum cancer as the primary site and mostly serous adenocarcinoma was the most common histopathology and 14.3% of the patients had endometrioid adenocarcinoma), 3.5% had prostate (median time from metastasis to castration-resistant status was 28 months) and 1.0% had pancreas cancer. Newly diagnosed cancer (breast and ovary) patients who had BRCA 1/BRCA 2 pathogenic/ likely pathogenic variant were younger than their previous cancer diagnosed (breast, ovary, and pancreas) parents who harbored BRCA pathogenic/likely pathogenic variant. We suggest that the genetic screening of BRCA 1/ BRCA 2 pathogenic/likely pathogenic variant is needed as a routine screening for those with a personal or family history of breast, ovarian, tubal, or peritoneal cancer. In addition, once BRCA 1 or BRCA 2 germline pathogenic variant has been identified in a family, testing of at-risk next-generation relatives earlier can identify those family members who also have the familial pathogenic variant, and thus need increased surveillance.
High Risk of Gestational Trophoblastic Neoplasia Development in Recurrent Hydatidiform Moles with NLRP7 Pathogenic Variations
Authors: Kocabey M. , Gulhan I. , Koc A. , Cankaya T. , Karatasli V. , Ileri A.
Published: May 2023

Objective

Pathogenic variations of the NLRP7 and KHDC3L genes are responsible for familial recurrent hydatidiform moles, a rare autosomal recessive phenomenon that can lead to severe comorbidities. Little is known about the diversity of genetic defects or the natural course of disease progression among recurrent hydatidiform mole cases from distinct ethnicities. In this study, we aimed to investigate the mutation profile and pregnancy outcomes in patients with multiple molar pregnancies.

Material and Methods

Three unrelated cases with recurrent molar pregnancies are included in this study. None of the patients had a known family history of molar pregnancy. Clinical findings and follow-up results are documented. Sanger sequencing is used to reveal genetic defects in exons and exon-intron boundaries of NLRP7 and KHDC3L genes.

Results

NLRP7 pathogenic variants were found in all three cases. In two cases, homozygous, c.2471+1G>A canonical splice cite variant was identified and in one case a homozygous, c.2571dupC (p.Ile858HisfsTer11) frameshift variant was identified. No variant in the KHDC3L gene was found in any case. In all cases, the development of gestational trophoblastic neoplasia complicated the clinical course and the treatment plans.

Conclusions

We found that defects of the NLRP7 gene are principally responsible for etiology in our region, and the mutation profile suggests a founder effect in the Turkish population. We suggest early genetic diagnosis and counseling in molar pregnancies and recommend close follow-up in terms of conversion to gestational trophoblastic neoplasia.
Climatically Determined Spatial and Temporal Changes in the Biomass of Betula spp. of Eurasia in the Context of the Law of the Limiting Factor
Authors: Usoltsev Vladimir Andreevich , Lin Hui , Shobairi Seyed Omid Reza , Tsepordey Ivan Stepanovich , Ye Zilin
Published: May 2023

Forest ecosystems play an essential role in climate stabilization, and the study of their capabilities in this aspect is of paramount importance. How climate changes affect the biomass of trees and stands in transcontinental gradients is unknown today? The objective of this study was (a) to verify the operation of the law of the limiting factor at the transcontinental level when modeling changes in the biomass of trees and stands of the genus Betula spp. of Eurasia in relation to geographically determined indicators of temperatures and precipitation, and (b) to show the possibility of using the constructed climate-conditioned models of tree and stand biomass in predicting temporal changes in tree and stand biomass based on the principle of space-for-time substitution. As a result of the implementation of the principles of the limiting factor and space-for-time substitution, a common pattern has been established on tree and stand levels: in sufficiently moisture-rich climatic zones, an increase in temperature by 1 °C with a constant amount of precipitation causes an increase in aboveground biomass, and in moisture-deficient zones, it decreases; in warm climatic zones, a decrease in precipitation by 100 mm at a constant average January temperature causes a decrease in aboveground biomass, and in cold climatic zones, it increases.
Forest Provisioning Ecosystem Services in Babile Elephant Sanctuary, Ethiopia
Authors: Hussein Abdulbasit , Workeneh Sintayehu
Published: May 2023

The study was conducted at Babile Elephant Sanctuary (BES) to identify and document the use and importance of provisioning ecosystem services (ESs). ESs were identified using questionnaire surveys from 110 households in three villages located inside and adjacent to BES by random sampling method. The importance attributed to each ES was evaluated using a descriptive rank analysis. Ordered logistic regressions were used to test whether and how socioeconomic factors influenced the importance attributed to ESs. The most used services were determined based on the percentage of respondents who used a particular service. Fodder, fuelwood, and construction were ranked the most important and used ESs. Age and gender significantly played important roles in people’s perceptions of the importance of ESs. This result suggests that the consequence of human-induced disturbance on woody species diversity and natural forest ESs appeared to be negative depending on the type and intensities of the disturbances.
Interaction and collaboration in Lithuanian schools during COVID-19 pandemic distance learning
Authors: Adomaitis Irmantas , Dauksiene Estela , Trepule Elena
Published: May 2023

Interaction and collaboration are essential pillars of successful learning.. The study aimed to find out how school communities collaborated during the COVID-19 pandemic and to assess the importance of collaboration in addressing the challenges faced. The selection of eight schools was made in a targeted way, considering that the participating schools would have chosen different virtual learning environments or technologies used for distance learning; and that schools would be of different types and sizes, and from different regions of Lithuania.. Three methods were used in this qualitative study: analysis of scientific literature, expert interviews, and focus group discussions. The results of our study confirmed that the focus of distance learning is on technological solutions, but not on the methodologies and strategies used to organise learning in virtual learning environments. Moving ‘traditional’ teaching to virtual space has become a key strategy for organising learning in virtual learning environments. The transfer of ‘traditional’ teaching strategies to distance learning not only limits the impactful interaction in virtual learning environments but also encourages ‘academic dishonesty’ among students. The success of distance learning strongly depends on students’ motivation, as well as their ability to organise their learning, solve problems in teams and critically evaluate the information provided.
Criminal Liability for (Self)-Liberation of a Person Legally Deprived of Liberty Under German, Swiss, Austrian and the Principality of Liechtenstein’s Law
Authors: Poniatowski Piotr
Published: May 2023

The subject of the article are the regulations concerning the escape of a person legally deprived of liberty, that are in force in countries with a Germanic legal tradition. The analysis of German, Swiss, Austrian and the Principality of Liechtenstein’s law is conducted against a background of Polish solutions. The aim of the study is to present similarities and differences between the solutions adopted in particular German-speaking countries, as well as between these solutions and the regulations contained in the Polish Penal code.
3-D Imaging Lidar Based on Miniaturized Streak Tube
Authors: Tian Liping , Shen Lingbin , Xue Yanhua , Chen Lin , Chen Ping , Tian Jinshou , Zhao Wei
Published: May 2023

Streak Tube Imaging Lidar (STIL), with advantages of non-scanning working mode, small distortion, high image framing rate, high resolution in low contrast environment, compact structure, easy miniaturization and high reliability, has a wide range of applications in military, aerospace, space confrontation, attack and defense, and marine law enforcement. This article introduces the principle of single-slit and multi-slit streak tube imaging lidar. It also introduces a single-slit general streak camera that can be used for imaging lidar. In addition, a multi-slit miniaturized streak tube with a single-lens focusing system with a total length of about 200 mm has been designed. The results of the 3D electromagnetic simulation show that the effective photocathode area of this streak tube reaches 36 mm × 36 mm, the temporal resolution is better than 50 ps, the dynamic spatial resolution can reach 12 lp/mm, and the whole photocathode can accommodate at least 19 slits in the effective detection range. The streak tube has a meshless structure, which is highly reliable. The streak tube can be used to increase the field of view of the imaging lidar system, improve the reliability, and achieve system miniaturization.
Impact of Covid-19 on the Psychology of Coaches
Authors: Bebetsos Evangelos , Konstantinidis Christos , Bebetsos George
Published: May 2023

The development of the COVID-19 pandemic, according to the World Health Organization (WHO), raises concerns about heightened stress and anxiety in people’s lives. The purpose of this research was to investigate the emotional influence of COVID-19 that professional coaches faced and how they managed to deal with social seclusion during the second wave of COVID-19. More precisely, it was investigated whether the age and educational level of coaches had an impact on their psychological condition during this period. The sample consisted of 605 Greek National coaches, 398 men, 206 women, and one coach who did not indicate sex preference, between the ages of 18-67 (M=38.18, SD=11.19). The results indicated the age differences between the youngest and oldest groups, and between high school and Ph.D. graduates. Overall, it was found that the Greek version of ERQ constitutes a reliable instrument for measuring emotion regulation situations in a professional sports environment.
Influence of Teaching Digital Competence and Professional Competencies on the Professional Performance of the Soccer Coach
Authors: Parra-Camacho David , Fernández-Piqueras Rocio , Ballester-Esteve Ignacio
Published: May 2023

The main objective of this article is to design a structural equation model to evaluate the predictor variables of professional performance in soccer coaches (PPSC), digital teaching competence (DTC) and professional competences of soccer coaches (PCSC). A sample of 612 coaches was taken from the different training levels of the Valencian Community (FFCV) in Spain, managed by UEFA.. The results of the causal relationship model showed a good overall fit of the model. A statistically significant positive relationship was found to exist with the professional performance of soccer coaches in both the use of digital competencies (DTC) and the professional competence of soccer coaches (PCSC). A statistically significant positive relationship was also observed between the use of digital competencies and the professional competence of soccer coaches. From the results obtained, it can be affirmed that the change generated by UEFA in the training of coaches in emerging technologies increases their professional performance.
Perception of Touch in the Physiotherapist-Patient Relationship
Authors: Bystrzycka Karolina , Przyłuska-Fiszer Alicja , Rekowski Witold , Wójcik Agnieszka
Published: May 2023

The aim of the study was to find out how values and norms related to touch are perceived in the physiotherapist-patient relationship. 149 physiotherapists and 100 patients participated in the study. The questionnaire used in the survey was prepared in two versions, both containing the same 30 items describing the use of therapeutic touch from two perspectives. The respondents had to provide their answers on 6-point ordinal scales with the centre excluded. In our analyses we treated the applied research tool as a scale of fulfilment of touch-related norms in the case of therapists and, respectively, a scale of expectations of fulfilment of these norms in the case of patients. The reliability of the tool was checked with Cronbach’s α method. Factor analysis, Student’s t-test and one-way analysis of variance were used to develop the obtained results.

In a therapeutic situation, the surveyed patients expect most of all that touch will express care. Physiotherapists are driven mainly by their professional competence in applying touch. A comparison of the obtained results on a scale depicting the fulfilment of norms underlying therapeutic touch has shown that the level of patients’ expectations concerning physiotherapists’ use of touch in therapy situations is lower than the physiotherapists’ declared level of fulfilling norms and values connected with this situation. The gender and age of physiotherapists were not found to differentiate axiological and normative declarations related to touch. Patients with higher education and women tend to express much higher expectations with respect to touch therapy.
Clinical Characterization of the Pilot Sample of an Online Short-Term Therapy for Internet Use Disorder
Authors:   Freie Universität Berlin, Basenach Lara
Published: May 2023

Rationale: Internet Use Disorders are associated with substantial intraindividual and societal impairments. For the treatment of addictive online behaviors, a novel online short-term therapy was implemented and embedded in the randomized controlled trial Stepped Care Approach for Problematic Internet use Treatment (SCAPIT; ID: DRKS00025994).
Analisis Sistem Website Sekolah Adiwiyata Menggunakan Website Quality (WEBQUAL)
Authors: Fauzan Muhamad Nur , Nurdiawa Odi , Wijaya Yudhistira Arie
Published: May 2023

Pertumbuhan teknologi dalam pencarian data salah satunya adalah website, sebagai media yang disediakan lewat koneksi internet, dimana pengguna bisa mengakses seluruh tipe data dimanapun serta kapanpun sepanjang terkoneksi dengan jaringan internet. Web telah menjadi bagian dari organisasi nirlaba termasuk pula lembaga pemerintahan. Sistem data web Sekolah Adiwiyata Kota Cirebon dapat diakses secara publik baik oleh pihak internal sekolah maupun masyarakat luas. Permasalahan yang dibahas yaitu Bagaimana membuat dan merancang web sekolah dengan Metode Webqual 4.0” dan belum adanya system yang dapat menghasilkan informasi yang baik dan efisien sehingga perlu dibuatkan website sekolah menggunakan metode WebQual-4.0. Tujuan penelitan ini untuk menguji sejauhmana pengaruh kulaitas khasiat (Usabilitiy), Mutu Data (Information Quality), Mutu Interaksi Pelayanan (Service Interaction Quality) serta kepuasan pengguna dari totalitas (Overall Impression). Metode yang digunakan dengan pendekatan mulai pengumpulan informasi kuesioner yang dibagikan kepada responden sebanyak 200 responden juga menggunakan metode WebQual, dilanjutakan dengan Uji Regresi Linear Simpel, uji F serta uji T, apabila kuesioner tersebut belum valid dan reliabel, dilakukan kembali pengujian. namun apabila informasi sudah valid serta reliable hingga informasi tersebut layak untuk duterapkan. Hasil penelitian ini menghasilkan nilai akurasi baik usability, information quality, mutu interaksi, service interaction quality mempengaruhi terhadap kepuasan pengguna, sebesar 78,4%.
Symphony and Maintenance of Seized Ships: Experimenting U.S Maritime Court’s Practice in Nigeria
Authors: Abdulkadir Abdulrazaq Owolabi , Lawal Saheedat Owolabi
Published: May 2023

Maintaining and managing seized ships is a critical aspect of the maritime industry worldwide. In countries such as the United States, measures are implemented to ensure that seized vessels are adequately managed and maintained during maritime proceedings. In contrast, when a ship is seized in Nigeria, there is often little assurance that the responsible authorities will maintain the vessel efficiently. Therefore, it is essential to investigate the reasons behind this lack of assurance and to identify potential solutions to improve the current state of the country’s maritime sector. This research employs a doctrinal methodology, analyzing statutory provisions and case law to collect data from legal textbooks, journal articles, and various online resources. This paper aims to discuss the circumstances under which states can seize ships, the procedural framework for ship arrest in Nigeria, and the forfeiture of vessels. Additionally, it compares these procedures with practices in the U.S. maritime sector, examines the challenges faced by the Nigerian maritime industry, and offers recommendations for improving ship maintenance. These recommendations include the establishment of a dedicated Maritime or Admiralty Court and the implementation of a bond system by the owners of seized vessels for their release pending the resolution of maritime proceedings, as practiced in the U.S..
O processo de formação de professores/as de Educação Física e a Política de Assistência Estudantil: estado do conhecimento
Authors: Viana Gabriela da Silva , Francisco Marcos Vinicius
Published: May 2023

Esta investigação visa analisar o estado do conhecimento das Políticas de Assistência Estudantil brasileiras durante o processo de formação de professores/as de Educação Física sob a perspectiva da produção em Programas de Pós-Graduação stricto sensu. Por meio da Biblioteca Digital Brasileira de Teses e Dissertações, procedeu-se à busca de teses e dissertações defendidas em Programas de Pós-Graduação vinculados às áreas de Educação, Educação Física e Serviço Social publicadas entre 2011 e 2021. Os materiais selecionados foram problematizados à luz do materialismo histórico-dialético. Os resultados revelaram a ausência de teses e/ou dissertações na área da Educação Física que contemplem a Política de Assistência Estudantil no processo de formação de professores/as. Por outro lado, as investigações reforçam a Assistência Estudantil como um mecanismo garantidor da permanência de estudantes economicamente menosfavorecidos/as, além de figurar como elemento protagonista na valorização da profissão docente.
Subjective evaluation of the quality of sleep of the main caregiver of a child or a teenager with cerebral palsy
Authors: Silva Weslei , Melo Jessica , Obrecht Andrea , Crippa Ana Chrystina
Published: May 2023

OBJECTIVE: Subjectively evaluate the quality of sleep of a main caregiver of a child or a teenager with cerebral palsy. METHODS: Prospective transversal study, with sample of 55 main caregivers of children or teenagers diagnosed with cerebral palsy. Socioeconomic data was collected through a general data record and quality of sleep data through Pittsburgh sleep quality index. Caregivers of 18 years old or less were deleted of the study. The data was tabulated in Excel® spreadsheet and analyzed by StatSoft Statistica software, version 10, to identify the frequencies and descriptive statistics obtained through the questionnaires. RESULTS: Most of main caregivers consider their sleep quality good (50.9%). However, just 21 sleep the appropriate number of hours for the effective performance of daily adult functions, while 85.44% have sleep latency greater than 15 minutes and only 27.27% do not have daytime drowsiness. Sleep efficiency was greater than 85% for 67.27% of the sample and 47.26% feel moderate or much unwillingness or lack of enthusiasm for daily activities. CONCLUSIONS: The obtained results allow us to identify changes in the quality of sleep of the main caregivers of children or adolescents with cerebral palsy, which questions the individual perception of most participants as to the presence of good quality of sleep. Therefore, evaluation of those participants with polysomnography is indicated in order to complement the analysis of sleep quality
The Physiology of Thermoregulation in Exercise
Authors: Lenasi Helena , Šijanec Janez
Published: May 2023

During physical exercise, the production of heat in the working skeletal muscles increases, imposing heat stress on the body. Thermoregulatory mechanisms induce adjustments of cutaneous vascular conductance and thus skin blood flow (SkBF), sweating rate, and increased cardiac output to achieve thermal homeostasis. The response depends on the intensity, type, duration of exercise, and environmental temperature: during extreme exercise in a hot environment SkBF can attain up to 7 L/min compared to 300 mL/min at rest whereas the sweating rate can reach as high as 4 L/h. Due to opposing non-thermal reflexes, the thermoregulatory response of SkBF during exercise differs from that at rest: the threshold to induce vasodilation in the skin is shifted to higher body core temperature and the sensitivity of the “SkBF to-core temperature” slope is altered. Regular training induces better adaptations to physical stress which enable sportsmen to eliminate additional heat more optimally. The review emphasizes physiological mechanisms involved in thermoregulation during exercise and exposes some thoughts regarding the estimation t of the core temperature in humans, as well as some new approaches for an up-to-date assessment of parameters important for appropriate heat dissipation thereby maintaining core temperature.
Machine learning-based prediction of activation energies for chemical reactions on metal surfaces
Authors: Hutton Daniel J. , Cordes Kari E. , Michel Carine , Göltl Florian
Published: May 2023

In computational surface catalysis, the calculation of activation energies of chemical reactions is expensive, which in many cases limits our ability to understand complex reaction networks. Here, we present a universal, machine learning-based approach for the prediction of activation energies for reactions of C, O, and H containing molecules on transition metal surfaces. We rely on generalized Bronsted-Evans-Polanyi relationships in combination with machine learning-based multiparameter regression techniques to train our model for reactions included in the University of Arizona Reaction database. In our best approach, we find a Mean Absolute Error for activation energies within our test set of 0.15 eV if the reaction energy is known and 0.19 eV if the reaction energy is unknown. We expect that this methodology will often replace the explicit calculation of activation energies within surface catalysis when exploring large reaction networks or screening catalysts for desirable properties in the future.