bluuebunny/crossref_metadata_2025 huggingface dataset:
Is it effective to do mathematical analysis for the etiology of nocturia using the nocturia indices derived from the frequency volume chart?
Authors: Kang Woocheol , BAE Hoyoung , Park Eun Ji , Yoon Ji Hyung , Kwon Taekmin , Park Sungchan , Moon Kyung Hyun , Cheon Sang Hyeon , Kim Seong Cheol
Published: June 2023

The aim of this study was to determine the problems involved in using a mathematical calculation to analyze the pathophysiology of nocturia using a frequency volume chart (FVC). In this retrospective study, we reviewed 253 patients who completed the FVC during ≥3 days for nocturia from January 2017 to February 2019. The etiology of nocturia was defined as a combination of four pathophysiologies, including nocturnal polyuria (NP), decreased bladder capacity (dBC), decreased nocturnal bladder capacity, and global polyuria. To analyze the differences according to diagnostic criteria for NP and dBC, two definitions were classified. Definition 1: NP is nocturnal polyuria index (NPi)>0.35 and dBC as maximal voided volume (MVV)<325 mL. Definition 2: NP is NPi=0.20-0.33 depending on age and dBC as MVV<200 mL. The MVV in the FVC for ≥3 days was significantly higher than that for 1 day (330 mL vs. 400 mL, p<0.001). During the entire FVC period, all pathophysiology remained unchanged in only 16.6% of cases (inter-day variation). Of 323 days in which nocturia occurred ≥2 per night, 118 days (36.5%) full bladder voiding of nocturia was not the same for each day (inter-nocturnal variation). According to definitions 1 and 2, the serial changes of NP and dBC showed different patterns. The mathematical calculation used in analyzing the pathophysiology of nocturia using an FVC has problems such as differences according to the duration of FVC and inability to express inter-day and inter-nocturnal variations. Therefore, this mathematical calculation is not helpful when determining the treatment modality for nocturia.
Association between lipid-lowering drugs and bone mineral density: A study employing drug-target Mendelian randomization
Authors: Ma Weiwei , Chen Honggu , Yang Xiaohong , Ruan Xiaofeng , Huang Wenzhuo , Tang Hongtu , Hu Xia
Published: June 2023

Purpose: This study aimed to evaluate the causal association between lipid phenotypes mediated by drug targets and bone mineral density using a two-sample Mendelian randomization approach.
Methods: Mendelian randomization analysis was conducted utilizing publicly available pooled-level GWAS data for lipid traits. Instrumental variables were selected based on specific lipid-lowering targets, and inverse variance weighting, weighted median, and MR Egger methods were employed. Sensitivity analyses were performed to ensure the robustness of the results.
Results:This study aimed to investigate the association between LDL cholesterol levels mediated by specific genes and bone mineral density (BMD) outcomes. Firstly, HMGCR-mediated LDL cholesterol showed a significant association with both H-BMD (β = -0.086, 95%CI: 0.117 to 0.055, p = 5.420 × 10-8 ) and TB-BMD (β = 0.193, 95%CI: 0.288 to 0.098, p = 7.350× 10-5 ). APOB-mediated LDL cholesterol demonstrated suggestive associations with FA-BMD (β = 0.210, 95%CI: 0.044 to 0.376, p = 0.013) and H-BMD (β = -0.032, 95%CI: -0.061 to -0.004, p = 0.027). Similarly, CETP-mediated LDL cholesterol showed suggestive relationships with FA-BMD (β = 0.315, 95%CI: 0.102 to 0.528, p = 0.004) and H-BMD (β = 0.055, 95%CI: -0.092 to -0.018, p = 0.027). LDLR-mediated LDL cholesterol was associated with H-BMD (β = -0.022, 95%CI: 0.041 to 0.003, p = 0.025) and LS-BMD (β = 0.124, 95%CI: 0.017 to 0.231, p = 0.023). However, no substantial evidence was found for an association between PCSK9-mediated LDL cholesterol, NPC1L1-mediated LDL cholesterol, and BMD outcomes.
Conclusion: Our study provides significant findings supporting the protective effect of HMGCR inhibitors on BMD. Associations were also observed between APOB, CETP, and LDLR-mediated LDL cholesterol and BMD at different skeletal sites. These results contribute to our understanding of the relationship between cholesterol-related genes and bone health, suggesting potential therapeutic targets for improving bone density.
The comparison of the consultation-liaison in the psychiatry department of a general hospital before and after the outbreak of COVID-19
Authors: Wang Xuemei , Yang Yuyin , Cui Hongmei , Zhang Huiran , Ming Qingsen , Du Shulin , Li Shuyun , Li Zezhi
Published: June 2023

Objective: To compare the status of the consultation-liaison in the psychiatry department of inpatients in a general hospital before and after the outbreak of COVID-19.
Methods: 842 patients in a tertiary hospital during 2019 and 904 patients since the beginning of the epidemic in 2020 were enrolled in this study. Demographic data, departments that requested consultation, mental disorders, and the psychiatric treatments were retrospectively analyzed.
Results: Among the 1746 patients, most patients were 45 to 70 years old. The department of hematology received the most applications for consultation. In 2020, requests from the departments of cardiac and vascular surgeries, contrary to the emergency department, increased significantly. 32.6% patients were diagnosed with organic mental disorder. Delirium was the most common disorder, followed by anxiety and depression. After the COVID-19 outbreak in 2020, the stress-associated and sleep disorders increased.
Conclusions: In general hospitals, clinical departments have great demands forpsychiatric consultation.Since the pandemic, patients requiring consultations for stress-related disorders and sleep disorders increased. Moreover, patients with cardiac and major vascular surgeries suffering from mental and emotional disturbances also increased. The ability of non-psychiatrists in identifying and treating mental disorders and the awareness of biopsychosocial (BPS) models need to be improved.
Muometric positioning system (muPS) utilizing direction vectors of cosmic-ray muons for wireless indoor navigation at a centimeter-level accuracy
Authors: Tanaka Hiroyuki K.M.
Published: June 2023

Since the development of many future technologies are becoming more and more dependent on indoor navigation, various alternative navigation techniques have been proposed with RF, acoustic, and laser beam signals. In 2020, muPS was proposed as a new indoor navigation technique; in 2022, the first prototype of wireless muPS was demonstrated in underground environments. However, in this first physical demonstration, its navigation accuracy was limited to 2 m -14 m which is far from the level required for the practical indoor navigation applications. This positioning error was an intrinsic problem associated with the clock that was used, and it was practically impossible to attain cm-level accuracy with this initial approach. This paper introduces the completely new positioning concept for muPS, Vector muPS, which retains the unique capacity to operate wirelessly in indoor environments while also achieving a cm-level accuracy. By utilizing an essentially different concept from what is used in other navigation techniques, (measuring the distance between the reference and the receiver), Vector muPS enables more flexible, and longer-term stable positioning. Anticipated applications and the future outlook of Vector muPS is also discussed.
Exploring factors associated with healthy and unhealthy dietary choices among pregnant women attending primary healthcare centres in Delta State, Nigeria
Authors: Ojo Tolulope , Jaiyesimi Boluwaji , Bamitale Toba , Kukoyi Olasumbo , Oni Olawale , Oluwadare Tunrayo , Oluwafemi Funmilayo , Orok Edidiong , Akpene Gillian
Published: June 2023

Dietary choices during pregnancy are critical for ensuring optimal nutritional practices among pregnant women. Poor nutritional practices have been associated with complications leading to significant maternal mortality rates annually. This study aimed to investigate the factors associated with dietary choices among pregnant women attending primary healthcare centres in Warri South LGA. A cross-sectional descriptive survey design was used for this study, and a multi-stage sampling technique was employed to draw a sample of 322 pregnant women. Relevant information was collected using a semi-structured, validated questionnaire on dietary choice of pregnant women (DCQ). Results from the logistic regression analysis revealed that marital status and place of residence were significantly associated with food consumption pattern (FCP) (P < 0.05). Pregnant women who were divorced (OR:0.18; 95% CI: 0.03–1.02; p = 0.05) or separated (OR:0.20; 95% CI: 0.04–1.03; p = 0.05) were significantly less likely to engage in unhealthy food consumption patterns. Furthermore, pregnant women in rural (OR:0.35; 95% CI: 0.15–0.82; p = 0.02) and semi-urban areas (OR:0.42; 95% CI: 0.19–0.91; p = 0.03) were significantly less likely to engage in unhealthy food consumption. Lack of knowledge of food significantly increased the likelihood for unhealthy food consumption patterns (OR:1.75; 95% CI: 0.99–3.11; p = 0.05). The Chi-square result showed that psychological (p < 0.01) and religious factors (p < 0.00) were significantly associated with food consumption patterns of the pregnant women. It is recommended that preconception education should be compulsory for all couples, and nutrition-education and counselling given during each antenatal visit should be intensified. Programs that involve husband support should also be organized, and men should be mandated to attend such programs with their wives.
Dental Unit Waterline Testing Practices: An 11-Year Retrospective Study
Authors: Buitrago Juan M. , Kolbe Rob J. , Siqueira Michelle F.
Published: June 2023

Objectives
This retrospective study examined the dental unit waterline (DUWL) testing practices of numerous Saskatchewan clinics over a period of 11 years, with an emphasis on their responses after identification of high microbial levels.
Materials and Methods
Dental clinics (n = 129) aseptically collected samples of output water from their air/water syringes, handpieces, and ultrasonic scaler lines using Sigma-Aldrich® waterline test kits and delivered them to a quality assurance laboratory. Tests were incubated for seven days at room temperature, and those with heterotrophic plate counts > 500 CFU/mL were reported as failures. Statistical analyses were performed on a database containing 3,567 test results.
Results
Participating clinics submitted an average of 10 DUWL tests per year. Overall, 21% of tests failed, and a moderate positive association (rs = .48, p < 0.001) was found between clinics’ DUWL testing frequency and failure rate. Only 7% of failed DUWL tests were followed up by collection of a subsequent test within 14 days, of which 46% still exceeded the 500 CFU/mL threshold.
Conclusions
Our findings demonstrate an association between DUWL testing frequency and detection of unacceptable microbial levels, along with infrequent retesting and often-inadequate intervention after a failed test. This suggests the need for further efforts at the regulatory and educational levels to maintain adequate water quality during dental treatment.
Clinical Relevance:
Procedural water can become contaminated in DUWLs and endanger patients. Regular DUWL monitoring and evidence-based interventions to treat contaminated systems are necessary to safeguard patient health.
WITHDRAWN: Insight into Genetic × Epidemiological factors in male infertility: synergistic effect of AZFc partial deletions and habits of smokeless-chewing tobacco
Authors: Dutta Saurav , Paladhi Pranab , Pal Samudra , Srim Souvik , Bose Gunja , Ghosh Papiya , Chattopadhyay Ratna , Ghosh Sujay
Published: June 2023

The Y chromosome AZF partial deletions exhibit variations in its association with male infertility across the population divides, and intriguing. Here we have analysed distinct partial deletions (gr/gr, b1/b3 and b2/b3) of the AZFc region among the 728 Bengali-speaking men and compared them with 264 age-matched proven-fertile control subjects. The gr/gr deletion was found to be frequent among azoospermic (P = 0.001) and oligozoospermic (P = 0.03) subjects, and b1/b3 deletions were detected to be significant among severe-oligozoospermic men (P = 0.0405). Furthermore, we analysed the interactions of these deletions with the habits of smokeless chewing tobacco among the participating subjects, taking opportunity of large epidemiological data of the participating subjects. The logistic regression model revealed that the infertile subjects bearing any type of microdeletion and also SCT users had an elevated risk of infertility (P = 0.002). Our work helps to get more insight into the cause of male infertility in the light of gene-environment interaction (G × E) and brings us a significant step closer towards understanding the aetiology of spermatogenesis failure in men.
Genetic aspects underlying the Normocalcemic and Hypercalcemic phenotypes of Primary Hyperparathyroidism
Authors: Viviani Arianna , COLANGELO Luciano , Ciminelli Bianca Maria , Novelletto Andrea , Sonato Chiara , Occhiuto Marco , Cipriani Cristiana , Diacinti Daniele , De Martino Viviana , Gianni Walter , Pepe Jessica , Minisola Salvatore , Malaspina Patrizia
Published: June 2023

Purpose
Hypercalcemic primary hyperparathyroidism (PHPT) is a common endocrine disorder that has been very well characterized. In contrast, many aspects of normocalcemic primary hyperparathyroidism (NPHPT) such as natural history, organ damage, and management are still matter of debate. In addition, both the pathophysiology and molecular basis of NPHPT are unclear. We investigated whether PHPT and NPHPT patient cohorts share the same pattern of genetic variation in genes known to be involved in calcium and/or bone metabolism.
Research design and methods
: Genotyping for 9 single nucleotide polymorphisms (SNPs) was performed by Real-Time PCR (TaqMan assays) on 27 NPHPT and 31 PHPT patients evaluated in a tertiary referral Center. The data of both groups were compared with 54 in house-controls and 503 subjects from the 1,000 Genomes Project. All groups were compared for allele/haplotype frequencies, on a single locus, two loci and multi-locus basis.
Results
The NPHPT group differed significantly at SNPs in OPG and ESR1. Also, the NPHPT cohort was peculiar for pairwise associations of genotypes and for the overrepresentation of unusual multilocus genotypes.
Conclusions
Our NPHPT patient set harboured a definitely larger quota of genetic diversity than the other samples. Specific genotypes may help in defining subgroups of NPHPT patients which deserve ad hoc clinical and follow-up studies.
Change of deep subduction seismicity after a large megathrust earthquake
Authors: Gardonio Blandine , Marsan David , Bodin Thomas , Socquet Anne , Durand Stephanie , Radiguet Mathilde , Ricard Yanick , Schubnel Alexandre
Published: June 2023

Subduction zones are home to the world’s largest and deepest earthquakes. Recently, large-scale interactions between shallow (0-60 km) and intermediate (80-150km) seismicity have been evidenced before megathrust earthquakes along with large-scale changes in surface motion. Large-scale deformation transients following major earthquakes have also been observed possibly due to a change in slab pull or to a bending/unbending of the plates, which suggests the existence of interactions between the deep and shallow parts of the slab. In this study, we analyze the spatio-temporal variations of the Japanese seismicity before and after the 2011/3/11 Mw9.0 Tohoku-oki earthquake. We observe that the rate of the intermediate to deep (150-450km) seismicity underwent a deceleration of 55% south of the rupture zone and an acceleration of 30% north of it, coherent with the GPS surface displacements. This shows for the very first time how a megathrust earthquake can affect the stress state of the slab over a 2500 km lateral-range and a large depth range, demonstrating that earthquakes interact at a much greater scale than the surrounding rupture zone usually considered. Our vision of subduction zones must consequently be renewed as a whole, from shallow to large depths.
Ridge regression and deep learning models for genomewide selection of complex traits in New Mexican chile peppers
Authors: Lozada Dennis N. , Sandhu Karansher Singh , Bhatta Madhav
Published: June 2023

Background. Genomewide prediction estimates the genomic breeding values of selection candidates which can be utilized for population improvement and cultivar development. Ridge regression and deep learning-based selection models were implemented for yield and agronomic traits of 204 chile pepper genotypes evaluated in multi-environment trials in New Mexico, USA.
Results. Accuracy of prediction differed across different models under five-fold cross-validations, where high prediction accuracy was observed for highly heritable traits such as plant height and plant width. No model was superior across traits using 14,922 SNP markers for genomewide selection. Bayesian ridge regression had the highest average accuracy for first pod date (0.77) and total yield per plant (0.33). Multilayer perceptron (MLP) was the most superior for flowering time (0.76) and plant height (0.73), whereas the genomic BLUP model had the highest accuracy for plant width (0.62). Using a subset of 7,690 SNP loci resulting from grouping markers based on linkage disequilibrium coefficients resulted in improved accuracy for first pod date, ten pod weight, and total yield per plant, even under a relatively small training population size for MLP and random forest models. Genomic and ridge regression BLUP models were sufficient for optimal prediction accuracies for small training population size. Combining phenotypic selection and genomewide selection resulted in improved selection response for yield-related traits, indicating that integrated approaches can result in improved gains achieved through selection.
Conclusions. Accuracy values for ridge regression and deep learning prediction models demonstrate the potential of implementing genomewide selection for genetic improvement in chile pepper breeding programs. Ultimately, a large training data is relevant for improved genomic selection accuracy for the deep learning models.
Ionospheric response to the 2020 Samos earthquake and tsunami
Authors: Alfonsi Lucilla , Cesaroni Claudio , Hernandez-Pajares Manuel , Astafyeva Elvira , Bufféral Simon , Elias Panagiotis , Belehaki Anna , Tsagouri Ioanna , Yang Heng , Guerra Marco
Published: June 2023

On 30 October 2020 at 11:51 UT, a magnitude 7.0 earthquake occurred in the Dodecanese sea (37.84°N, 26.81°E, 10 km depth) and generated a tsunami with an observed run-up of more than 1 meter on the Turkish coasts. Both the earthquake and the tsunami produced acoustic and gravity waves that propagated upward, triggering coseismic and co-tsunamic ionospheric disturbances.
This paper presents a multi-instrumental study of the ionospheric impact of the earthquake and related tsunami based on ionosonde data, ground-based Global Navigation Satellite Systems (GNSS) data and data from DORIS beacons received by Jason3 in the Mediterranean region.
Our study focuses on the Total Electron Content to describe the propagation of Medium Scale Travelling Ionospheric Disturbances (MSTIDs), possibly related to gravity waves triggered by the earthquake and tsunami. We use simultaneous vertical ionosonde soundings to study the interactions between the upper and lower atmosphere, highlighting the detection of acoustic waves generated by the seismic Rayleigh waves reaching the ionosonde locations and propagating vertically up to the ionosphere.
The results of this study provide a detailed picture of the Lithosphere-AtmosphereIonosphere coupling in the scarcely investigated Mediterranean region and for a relatively weak earthquake.
Distinctly altered lipid components in hepatocellular carcinoma relate to impaired T cell-dependent antitumor immunity
Authors: Cheng Xue , Wang Wei , Zhang Ziyao , Zhang Haoquan , Zhu Peng , He Ran , Wu Mi , Zhou Ting , Jiang Ying , Jiang Lang , Chen Yiqing , Wu Xiongwen , Liang Zhihui , Weng Xiufang
Published: June 2023

Background and aims:
T cells are master effectors of anti-tumor immunity in cancer. Recent studies suggest that altered lipid metabolism imposed by the tumor microenvironment constrains anti-tumor immunity. However, the tumor-associated lipid species changes that dampen T cell ability to control tumor progression are not fully understood. Here, we plan to clarify the influences of distinctly altered lipid components in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) on T-cell function, aiming to seek lipid metabolic targets for improving T cell anti-tumor effects.
Methods
Tumor tissues and non-tumor liver from HCC patients were collected for RNA-sequencing, lipid profiling and T cell characterizing, followed by correlation analysis. Additionally, the effects of significantly changed lipid components on anti-tumor potential of T cells were tested by in vitro cell experiments and/or in vivo tumor inoculated model.
Results
Altered lipid metabolism coincides with impaired T cell response in HBV-related HCC. Characteristic lipid composition, significantly marked by accumulation of long-chain acylcarnitines (LCACs) and reduction of lysophosphatidylcholines (LPCs), are found in the tumor tissue. Notably, LCACs accumulated are associated with T cells exhaustion and deficient functionality, while LPCs correlate to anti-tumor effects of T cells. In particular, supplement of LPCs, including LPC (20:0) and LPC (22:0), directly promote the activation and IFN-γ secretion of T cells in vitro, and suppress tumor growth in vivo.
Conclusions
Our study highlights the distinctly changed lipid components closely related to T cell dysregulation in HCC, and suggests a promising strategy by decreasing LCACs and increasing LPCs for anti-tumor immunotherapy.
Development and Validation of a Nomogram for New Vertebral Compression Fractures in Postmenopausal Female Patients Undergoing Percutaneous Kyphoplasty Surgery
Authors: Zheng Jianhu , Gao Yan , Yu Wenlong , Yu Ning , Jia Zetao , Wang Jin , Hao Yanke , Chen Yungang
Published: June 2023

Background: Postmenopausal women face a heightened risk of developing new vertebral compression fractures (NVCF) after experiencing osteoporotic vertebral compression fractures (OVCF) and undergoing percutaneous kyphoplasty (PKP). This study aims to develop and validate a novel Nomogram visual model capable of accurately predicting the occurrence of NVCF following PKP. The objective is to optimize treatment strategies and minimize the occurrence of new fractures.
Methods: A retrospective study was conducted on postmenopausal women diagnosed with OVCF who underwent PKP at the Affiliated Hospital of Shandong University of Traditional Chinese Medicine between January 2016 and January 2021. Patient data, including basic information, surgical details, imaging records, and laboratory test results, were collected. The patients were categorized into two groups based on the occurrence of NVCF: a new fracture group and a no new fracture group. Feature selection was performed using LASSO regression, and a Nomogram diagram was constructed. The model's differentiation, calibration, and clinical applicability were evaluated through receiver operating characteristic curve (ROC) analysis, calibration curves, and decision curve analysis (DCA).
Results: In this study, a total of 357 patients were included. The results of LASSO regression analysis indicated that cement leakage, poor cement diffusion, and endplate fracture were identified as independent predictors of NVCF. The development and verification of the Nomogram demonstrated its predictive ability and clinical applicability.
Conclusions: The study utilized LASSO regression to identify three independent predictors and developed a predictive model for predicting the occurrence of NVCF in postmenopausal women. The developed model effectively predicts the occurrence of NVCF in this population.
Challenges of measuring self-reported exposure to occupational biomechanical risk factors amongst people with low literacy engaged in manual labour: Findings from a cross-cultural adaptation and psychometric investigation in an African population with chronic low back pain
Authors: Igwesi-Chidobe Chinonso Nwamaka , Sorinola Isaac Olubunmi , Ozumba Benjamin Chukwuma , Godfrey Emma Louise
Published: June 2023

Purpose
Occupational biomechanical factors have been implicated in the aetiology and progression of low back pain (LBP). This study aimed to cross-culturally adapt and psychometrically investigate the occupational risk factor questionnaire (ORFQ) in a low literate Nigerian population with chronic LBP.
Methods
Forward and back translation of the original ORFQ by clinical and non-clinical translators was followed by an expert committee review. The adapted ORFQ was pre-tested amongst rural Nigerian adults with chronic LBP using cognitive think-aloud interviewing. Internal consistency (Cronbach’s alpha) and test–retest reliability (unweighted and linear weighted k statistic for item-by-item agreement, and intra-class correlation coefficient—ICC) were investigated amongst 50 rural and urban Nigerian dwellers with chronic LBP. Correlations between the adapted CSQ and measures of disability [World Health Organisation Disability Assessment Schedule (WHODAS 2.0), Roland Morris Disability Questionnaire (RMDQ), Back performance scale (BPS)], pain intensity [Eleven-point box scale (BS-11)] and social support [Multidimensional Scale of Perceived Social Support (MSPSS)], were used to test construct validity employing Spearman’s correlation analyses with 200 rural Nigerian dwellers with chronic LBP.
Results
Igbo-ORFQ was challenging to cross-culturally adapt due to difficulty conceptualising and concretising exposure to biomechanical risk factors. Item-by-item agreement, internal consistency (α = 0.84) and intraclass correlation coefficient (ICC = 0.83) were mostly good. Unexpected direction of correlations with disability, pain intensity, and social support prohibits establishment of construct validity of the biomechanical component of the Igbo-ORFQ.
Conclusions
The biomechanical component of the Igbo-ORFQ may have limited applicability to low literate populations self-employed in informal manual jobs.
New Riparian Forest Fragments Quickly Increase Carbon Stocks Baseline
Authors: Kafinga Muhsin H. , Martins Iuri S. , Antonini Yasmine , Messias Maria C. T. B. , Pinto Alexandre S. , Leite Mariangela G. P. , Kozovits Alessandra R.
Published: June 2023

In recent decades, the role played by planted forests in carbon sequestration and storage has been recognized as an essential ecosystem service for maintaining the quality of life on the planet. In this study we compared the carbon stocks in soil, litter and aboveground tree biomass in four riparian reforested strips in the surroundings of the State Hydroelectric Power Plant (UHE) of Volta Grande in Minas Gerais, Brazil. The planted forest strips ranged from 30 to 100 m wide and 10 to 20 years old. Despite this, no significant differences (p < 0.5) were found in C stocks among areas. Carbon stock in trees was about 86tMgC.ha− 1 on average. Litter carbon stocks varied from 4.15 to 6.59 MgC.ha− 1 and in the soil (0–30 cm), the values were about 31 MgC.ha− 1. Litter carbon stock was only significantly higher in narrower strips at (p < 0.1) probably due to an edge effect. Our results suggest that factors such as the management and protection of the reforested area and the surrounding landscape seem to exert a strong influence on the quality of the reforested fragments. Regardless, the reforested areas in the new riparian zones created on the banks of the dam increased C stocks by 40% in the first decade compared to the baseline of agricultural environments. This result corroborates other studies and encourages the restoration of riparian zones as an efficient and rapid mechanism for C sequestration plus other ecosystem services.
Comparison of Diagnostic Accuracies for FRAIL, PRISMA-7, and GFI scale to identify frailty in Older People: A diagnostic meta-analysis
Authors: Li Li , Zhao Chongyang , Deng Cong , Zhang Yuhui , Wang Qin , Kang Deying
Published: June 2023

Background
Frailty has become one of the most serious global public health challenges. Whether the assessments tools are useful for frailty needs further evaluation.
Objectives
This study aims to evaluate the diagnostic accuracy of measurement tools for frailty in older people.
Design
This study was registered on PROSPERO (registration number: CRD: 42023415074.) Medline, Web of Science, Embase, China Knowledge Resource Integrated Database (CNKI), Wanfang databases, and VIP databases were searched from their inception to March 31, 2022.
Measurements
Two reviewers independently scored quality of the studies based on the Quality Assessment of Diagnostic Accuracy Studies 2(QUADAS-2) tool in Review manager 5.4.1 software, a summary receiver operating characteristics (SROC) curve was plotted and area under curve (AUC)was calculated to evaluate the accuracy of the frailty assessment tool.
Results
A total of 23 articles were included. The sample size ranges from 45 to 1037. The pooled sensitivity, specificity and AUC of FRAIL was 0.75 (95% CI: 0.56 - 0.88), 0.81 (95% CI: 0.71 - 0.88) and 0.88 (95% CI: 0.85 - 0.91), respectively; the pooled sensitivity, specificity and AUC of PRISMA-7 scale was 0.81 (95% CI: 0.71 - 0.88), 0.78 (95% CI: 0.69 - 0.85) and 0.86 (95% CI: 0.82 - 0.88) , respectively; the pooled sensitivity, specificity and AUC of GFI was 0.72 (95% CI: 0.62 - 0.80), 0.74 (95% CI: 0.67-0.81) and AUC of 0.79 (95% CI: 0.76 - 0.83) , respectively.
Conclusion
Our study suggests that, compared with the FP scale, the FRAIL and PRISMA-7 scales have a wide range of applications in the frail older population.
Synthesis and X-ray structure of the first thioether of quinolin-2-one naming as 4,4'-thio-bis(1-methylquinoline-2(1H)-thione) and X-ray structure of 3,3'- methylenebis(4-hydroxy-1-methylquinolin-2(1H)-one)
Authors: Balboul Basmaa A. A. , Aly Ashraf A. , Fuhr Olaf , Osman Esraa M. , El-Haleem Lamiaa E. Abd
Published: June 2023

Synthesis and X-ray structure analysis of 4,4'-thiobis(1-methylquinoline-2(1H)-thione (I) and X ray structure analysis of 3,3'-methylenebis(4-hydroxy-1-methylquinolin-2(1H)-one (II) were carried out. The chosen compounds I and II are resembled in having a bridged atom or molecule between the two quinoline molecules. In compound I, sulfur atom represents the bridged atom, whereas the CH2 represents the bridged molecule in compound II. The structures of I [Monoclinic, a = 9.4906 (5), b = 9.4816 (6) and c = 19.2193 (15) Å, and compound II [hexagonal, a = 19.3922(5), b = 19.3922(5) and c = 4.06650(10) Å. X-ray structural data shows in compound II a two hydrogen bonds between the two C=O and two OH groups. The angular molecules of I are packed in a way that there are attractive π-π interactions between neighbouring molecules. The molecules of II are arranged in columns parallel to the c axis. Within these columns the V-shaped molecules are densely packed with attractive π-π stacking interactions.
How Do People Feel About COVID-19 Vaccine? An Analysis Of Twitter Polarization
Authors: Schiessl Djonata
Published: June 2023

With the growth of social media, some issues started to affect people's interactions and create polarization regarding sensitive themes. Recently, it happened with the COVID-19 Vaccines when celebrities and public authorities were against vaccines application. This polarization is implicating in the application of vaccines aggravating the impacts of the pandemic. We analyzed data from Twitter to understand how this polarization affected people's psychological aspects compared with traditional vaccines. Results indicated that Tweets related to COVID-19 had more engagement and generated more positive emotions than traditional vaccines. Conversely, traditional vaccines generated more negative emotions than the COVID-19 vaccine. Furthermore, other aspects regarding polarization were explored.
SNHG14 lncRNA as a tumor suppressor in adult non-M₃ AML patients; The diagnostic biomarker
Authors: Seifpour Saba , Atashi Amir , Zomorod Mina Soufi , Khaseb Sanaz , Tavangar Fatemeh , vajari Mahdi kohansal
Published: June 2023

Acute myeloid leukemia (AML) is one of the most common adult blood malignancies that engages hematopoietic myeloid progenitors. A large number of studies have shown the involvement of long non-coding RNAs (lncRNAs) in AML pathogenesis. This study aimed to investigate the expression profile of lnRNA SNHG14 and its role in adult non-M₃ AML pathogenesis, clinical features, and diagnosis. We compared the expression level of SNHG14 by qRT-PCR technique between bone marrow (BM) samples obtained from 50 adult non-M₃ AML patients and 49 healthy controls. We also investigate the correlation between clinicopathological characteristics of AML patients with low and high SNHG14 expression. The expression level of SNHG14 was significantly decreased in BM tissues of adult non-M₃ AML patients compared with healthy controls. Patients with low expression levels of SNHG14 were associated with poor overall survival (OS), while no correlation was observed between low expression levels of SNHG14 and relapse free survival (RFS). Thus, our findings suggest that SNHG14 expression has the potential to be a biomarker for diagnosing adult non-M₃ AML patients. Put together, our findings suggest that lncRNA SNHG14 could be used as a potential diagnostic biomarker and may provide insights into novel therapeutic targets in adult non-M₃ AML patients.
EpilConNet: A Novel Multi-Class Epileptic Seizure Classification Model through Layer Concatenation
Authors: Ghosh Sudip , _ Deepti , Gupta Shivam
Published: June 2023

Epilepsy is a neurological disorder characterized by recurrent seizures, which can affect individuals of all age groups, but infants and older individuals are particularly vulnerable. Sudden epileptic attacks can pose significant risks and be life-threatening, impacting the overall quality of life of affected individuals. With the progress made in medical science, Electroencephalography (EEG) has emerged as a valuable tool for diagnosing and predicting seizure occurrences. The availability of wearable EEG devices, including caps and helmets, has become increasingly prominent in the market. As a result, there has been a recent surge in the development of deep learning-based systems. These systems are helpful for diagnosis in hospital settings and for mobile applications that provide timely warnings and predictions regarding seizure onset. Most of the existing state-of-the-art (SOTA) approaches focus on distinguishing between healthy and epileptic patients. Some studies categorize individuals into three classes: healthy, experiencing the onset of a seizure, or currently having a seizure, specifically focusing on mobile applications. However, limited literature is available on the five-class problem, which is valuable for localization and diagnosis in hospitals and mobile applications. In this regard, we propose our novel model, named EpilConNet, and conduct extensive experiments on a real-world dataset to demonstrate its efficacy in all modes of classification.
Investigating the association between Work Family Conflict (WFC) and Generalized Anxiety Disorder (GAD) in an Australian community-based cohort study
Authors: Wang Tianying , Butterworth Peter , Cooklin Amanda , Strazdins Lyndall , Leach Liana
Published: June 2023

Purpose: Difficulties managing work and family demands are common and have been found to be associated with stress and poor mental health. However, very few studies have examined Work Family Conflict (WFC) in connection with diagnosable anxiety disorders (and none with Australian representative data). The current study investigated whether high WFC was significantly associated with a diagnosis of Generalised Anxiety Disorder (GAD) after controlling for a broad range of socio-demographic contextual factors, related psychosocial job, family and individual characteristics, and prior anxiety symptom history.
Methods: Data was analysed from an Australian population-based community cohort - the Personality and Total Health (PATH) Through Life project. Eligible participants (N=1159) were employed full-time or part-time, with data collected by both online questionnaire and face-to-face interview. Presence of Generalised Anxiety Disorder (GAD) in the past 12-months was diagnosed by the Composite International Diagnostic Interview (CIDI) and severe anxiety symptoms were measured using the Patient Health Questionnaire (PHQ).
Results: The findings consistently showed that those experiencing high WFC had higher odds of a GAD diagnosis (final adjusted model: DSM-V: OR: 2.55, CI: 1.38-4.70) as well as clinical levels of anxiety symptoms (PHQ: OR:2.61, CI:1.44,4.72). This was the case after controlling for an extensive range of covariates.
Conclusions: This is one of the first studies to show that WFC is associated with greater likelihood of GAD. The challenge of juggling both work and family can have far-reaching impacts - not just increasing distress broadly, but also increasing the likelihood of clinically diagnosable anxiety.
The management of recurrent urinary tract infection: non-antibiotic bundle treatment
Authors: Venturini Sergio , Reffo Ingrid , Avolio Manuela , Basaglia Giancarlo , Fabro Giovanni Del , Callegari Astrid , Tonizzo Maurizio , Sabena Anna , Rondinella Stefania , Mancini Walter , Conte Carmina , Crapis Massimo
Published: June 2023

Recurrent urinary tract infections (rUTIs) are a common condition with high morbidity and a negative impact on quality of life. They account for approximately 25% of all antibiotic prescriptions, posing a public health concern in an era of multi-drug resistant organisms (MDRO) surge. Various non-antibiotic management strategies have been trying to curb antimicrobials use, and many of them are individually effective to some degree, but there is no experience testing multimodal interventions. We created a “bundle of care” consisting of behavioural measures, vaginal and oral probiotics, D-mannose, and cranberry, to be followed for six months; we enrolled women with rUTIs over a three-year period to test it. Changes in rUTIs, antibiotic use, chronic symptoms, and quality of life were compared between the six months before and after enrolment. Forty-seven women were included in the study, six of whom were excluded from the final analysis. We observed a 76% reduction in urinary infections (p < 0.001) and a reduction in overall antibiotic exposure of more than 90% (p < 0.001); all chronic symptoms showed a trend towards reduction. Adherence to bundle was high (87.2%). Altogether, 80.5% of women experienced an improvement in their quality of life. In our experience, a bundle treatment protocol is effective in reducing recurrences and antimicrobial use in a cohort of women with rUTIs and results in subjective improvement in chronic symptoms and quality of life. Further research is needed to confirm these results.
Novel functional insights into the microbiome inhabiting marine plastic debris: critical considerations to counteract the challenges of thin biofilms using multi-omics and comparative metaproteomics.
Authors: Messer Lauren F. , Lee Charlotte E. , Wattiez Ruddy , Matallana-Surget Sabine
Published: June 2023

Background
Microbial functioning on marine plastic surfaces has been poorly documented, with only two studies using metaproteomics to unravel microbial genotype-phenotype linkages in the marine ‘plastisphere’. Here we provide a comprehensive methodological assessment for plastisphere metaproteomics, using multi-omics and data mining on thin plastic biofilms from an understudied cold environment, to provide unique insights into plastisphere metabolism. Our robust experimental design assessed DNA/protein co-extraction and cell lysis strategies, proteomics workflows, and diverse protein search databases, to encourage the more widespread application of these techniques to resolve plastisphere function.
Results
For the first time, we demonstrate the predominance and activity of hydrocarbonoclastic genera (Psychrobacter, Flavobacterium, Pseudomonas) within a primarily heterotrophic plastisphere. Correspondingly, oxidative phosphorylation, the citrate cycle, and carbohydrate metabolism were the dominant pathways expressed. We also identified quorum sensing and toxin-associated proteins in Streptomyces, stress response proteins expressed by Psychrobacter, Planococcus and Pseudoalteromonas, and xenobiotics degradation proteins in Psychrobacter and Pseudoalteromonas. Interestingly, a targeted search strategy identified plastic biodegradation enzymes, such as polyamidase, hydrolase, and depolymerase, expressed by rare taxa. In contrast to previous research, pathogenic genera were active, expressing virulence factors and mechanisms of antimicrobial resistance.
Conclusion
Our study demonstrates the power of multi-omics and comparative metaproteomics to resolve plastisphere functioning, to provide new bioengineering perspectives and improved assessment of the risks of plastic pollution.
Unleashing the Power of Evolutionary Machine Learning in CBIR: A Study of Kernelized Radial Basis Auto-Encoder Function Neural Network
Authors: Bose Anandh Sam Chandra , Singh Laxman , Qamar Shamimul , Uma S , Annabel L. Sherly Puspha , Singla Sanjay
Published: June 2023

The goal of Content-Based Image Retrieval (CBIR) is to compare a query image with similar images from a large dataset. Typically, the ranking of retrieved photos is based on how similar the representative features of the query image and the dataset images are. Machine learning (ML) methods have been investigated as a practical approach to decrease the semantic gap. This research proposes a novel technique that utilizes evolutionary machine learning in CBIR. The input image is processed and classified using a Kernelized Radial Basis Auto-Encoder Function Neural Network (Ker_RadBAEFNN). Then, the input neural network is optimized using reinforcement in CBIR. Experimental analysis is carried out in terms of accuracy, precision, recall, F-1 score, RMSE, and MAP for various input datasets. The suggested architecture has exceptional performance in feature learning without prior knowledge of the images, categorization, and optimization. The proposed method achieved 98% accuracy, 96% precision, 79% recall, a 66% F-1 score, a 69% RMSE, and a 59% MAP.
Data driven enrichment of historical low-resource languages for foundational NLP tasks and their neural network models
Authors:   , Ahmed Sajawel
Published: June 2023

In the recent past, we are making huge progress in the field of Artificial Intelligence. Since the rise of neural networks, astonishing new frontiers are continuously being discovered. The development is so fast that overall no major technical limits are in sight. Hence, digitization has expanded from the base of academia and industry to such an extent that it is prevalent in the politics, mass media and even popular arts. The DFG-funded project Specialized Information Service for Biodiversity Research and the BMBF-funded project Linked Open Tafsir can be placed exactly in that overall development. Both projects aim to build an intelligent, up-to-date, modern research infrastructure on biodiversity and theological studies for scholars researching in these respective fields of historical science. Starting from digitized German and Arabic historical literature containing so far unavailable valuable knowledge on biodiversity and theological studies, at its core, our dissertation targets to incorporate state-of-the-art Machine Learning methods for analyzing natural language texts of low-resource languages and enabling foundational Natural Language Processing tasks on them, such as Sentence Boundary Detection, Named Entity Recognition, and Topic Modeling. This ultimately leads to paving the way for new scientific discoveries in the historical disciplines of natural science and humanities. By enriching the landscape of historical low-resource languages with valuable annotation data, our work becomes part of the greater movement of digitizing the society, thus allowing people to focus on things which really matter in science and industry.
DIGITAL ISLAMIC NETWORK: BUILDING EXCELLENT SERVICE FOR CUSTOMERS AT BANK MUAMALAT TULUNGAGUNG IN THE DIGITAL ERA
Authors: Cahyaningtyas Ekalaka Febian , Fauza Nilna
Published: June 2023

Abstrak: Perkembangan teknologi pada era ini menunjukkan perkembangan yang begitu pesat. Dunia mengalami kemajuan luar biasa dalam teknologi dan inovasi. Kehadiran aplikasi Digital Islamic Network (DIN) sebagai platform digital yang bermanfaat disambut antusias masyarakat. Untuk itu penelitian ini bertujuan untuk mengetahui peranan aplikasi Digital Islamic Network (DIN) dalam meningkatkan pelayanan nasabah di Bank Muamalat KCP Tulungagung. Artikel ini menggunakan metode deskriptif-kualitatif dengan pendekatan penelitian lapangan dan penelitian kepustakaan. Sumber data yang digunakan dalam penelitian ini adalah sumber data primer dan sumber data sekunder. Hasil kajian menunjukkan bahwa Digital Islamic Network (DIN) di Bank Muamalat KCP Tulungagung berperan untuk memudahkan nasabah mendapatkan layanan yang berkualitas dan profesional dengan mewujudkan efektifitas dan efisiensi layanan perbankan kepada nasabah. Hal ini dibuktikan dengan peran Muamalat Digital Islamic Network (DIN) dalam meningkatkan kualitas pelayanan, memberikan kemudahan pelayanan kepada pelanggan, efisiensi waktu, memberikan jaminan keamanan bagi pelanggan, dan memberikan kepuasan pelayanan.

Abstract: The development of technology in the current era show growing rapidly. The world is experiencing tremendous progress in technology and innovation. The presence of the Digital Islamic Network (DIN) application as a beneficial digital platform is enthusiastically welcomed by the public. For this reason, this study aims to determine the role of Digital Islamic Network (DIN) applications in improving customer service at Bank Muamalat KCP Tulungagung. This article uses a descriptive-qualitative method with a field research and library research approach. Sources of data used in this study are primary data sources and secondary data sources. The result of the study shows that the Digital Islamic Network (DIN) at Bank Muamalat KCP Tulungagung plays a role in making it easy for customers to receive quality and professional services by realizing the effectiveness and efficiency of banking services to customers. This is proven by the role of Muamalat Digital Islamic Network (DIN) in improving the quality of service, providing easy service to customers, time efficiency, providing security guarantees for customers, and providing service satisfaction.
DESAIN PENYELESAIAN PERSELISIHAN HASIL PEMILIHAN GUBERNUR, BUPATI/WALIKOTA PASCA PUTUSAN MAHKAMAH KONSTITUSI NO. 55/PUU-XVII/2019
Authors: Shobahah Nurush , Rifai Much Anam
Published: June 2023

Diskursus desain penyelesaian perselisihan hasil Pemilihan Gubernur, Bupati dan Walikota (baca: Pilkada) kembali mengemuka tatkala Mahkamah Konstitusi membacakan Putusan No. 55/PUU-XVII/2019 pada tanggal 26 Februari 2020. Pada Putusan tersebut muncul istilah Pemilu serentak yang di dalamnya memuat penyelenggaraan Pilkada. Pertanyaan yang muncul kemudian adalah apakah Pilkada masuk kembali ke rezim Pemilu setelah dalam Putusan Mahkamah Konstitusi Nomor 97/PUU-XI/2013 dan UU Pilkada dinyatakan bukan bagian dari Pemilu. Terbukti UU Pilkada mengamanatkan pembentukan badan peradilan khusus untuk menyelesaikan perselisihan hasil Pilkada. Lantas bagaimana sebenarnya standing position Pilkada? Apakah bagian dari Pemilu atau tidak? Sebab standing position itu mempengaruhi desain penyelesaian perselisihan hasil Pilkada. Melalui penelitian hukum normatif dengan pendekatan peraturan perundang-undangan (statute approach), dan pendekatan konseptual (conceptual approach), terjawab bahwa Pilkada bukanlah bagian dari Pemilu sehingga Mahkamah Konstitusi tidak memiliki kewenangan untuk menyelesaikan perselisihan hasilnya. Perselisihan hasil Pilkada dapat diberikan kepada badan peradilan di bawah Mahkamah Agung. Pilihannya ada dua yakni diberikan kepada PTTUN atau dibentuk badan peradilan khusus. Dengan pertimbangan efektifitas dan efisiensi, penulis berpendapat sebaiknya diberikan kepada PTTUN.