bluuebunny/crossref_metadata_2025 huggingface dataset:
Thrust Vectoring of a Fixed Axisymmetric Supersonic Nozzle Using the Shock-Vector Control Method
Authors: Resta Emanuele , Marsilio Roberto , Ferlauto Michele
Published: December 2021

The application of the Shock Vector Control (SVC) approach to an axysimmetric supersonic nozzle is studied numerically. SVC is a Fluidic Thrust Vectoring (FTV) strategy that is applied to fixed nozzles in order to realize jet-vectoring effects normally obtained by deflecting movable nozzles. In the SVC method, a secondary air flow injection close to the nozzle exit generates an asymmetry in the wall pressure distribution and side-loads on the nozzle, which are also lateral components of the thrust vector. SVC forcing of the axisymmetric nozzle generates fully three-dimensional flows with very complex structures that interact with the external flow. In the present work, the experimental data on a nozzle designed and tested for a supersonic cruise aircraft are used for validating the numerical tool at different flight Mach numbers and nozzle pressure ratios. Then, an optimal position for the slot is sought and the fully 3D flow at flight Mach number M∞=0.9 is investigated numerically for different values of the SVC forcing.
Random Times for Markov Processes with Killing
Authors: Kondratiev Yuri G. , da Silva José Luís
Published: December 2021

We consider random time changes in Markov processes with killing potentials. We study how random time changes may be introduced in these Markov processes with killing potential and how these changes may influence their time behavior. As applications, we study the parabolic Anderson problem, the non-local Schrödinger operators as well as the generalized Anderson problem.
Chaos Control for a Fractional-Order Jerk System via Time Delay Feedback Controller and Mixed Controller
Authors: Xu Changjin , Liao Maoxin , Li Peiluan , Yao Lingyun , Qin Qiwen , Shang Youlin
Published: December 2021

In this study, we propose a novel fractional-order Jerk system. Experiments show that, under some suitable parameters, the fractional-order Jerk system displays a chaotic phenomenon. In order to suppress the chaotic behavior of the fractional-order Jerk system, we design two control strategies. Firstly, we design an appropriate time delay feedback controller to suppress the chaos of the fractional-order Jerk system. The delay-independent stability and bifurcation conditions are established. Secondly, we design a suitable mixed controller, which includes a time delay feedback controller and a fractional-order PDσ controller, to eliminate the chaos of the fractional-order Jerk system. The sufficient condition ensuring the stability and the creation of Hopf bifurcation for the fractional-order controlled Jerk system is derived. Finally, computer simulations are executed to verify the feasibility of the designed controllers. The derived results of this study are absolutely new and possess potential application value in controlling chaos in physics. Moreover, the research approach also enriches the chaos control theory of fractional-order dynamical system.
Treatment in AL Amyloidosis: Moving towards Individualized and Clone-Directed Therapy
Authors: Hegenbart Ute , Raab Marc S. , Schönland Stefan O.
Published: December 2021

Systemic amyloid light chain (AL) amyloidosis is a rare protein deposition disease caused by a clonal B cell disorder of the bone marrow. The underlying diseases can be plasma cell disorders (monoclonal gammopathy of clinical significance, smoldering or symptomatic myeloma) or B cell non-Hodgkin’s lymphoma (e.g., Waldenstrom’s disease or marginal zone lymphoma) with secretory activity. It is crucial to characterize the underlying disease very precisely as the treatment of AL amyloidosis is directed against the (often small) B cell clone. Finally, the detection of cytogenetic aberrations of the plasma cell clone will likely play an important role for choosing an effective drug in the near future.
Inducible Clindamycin Resistance and Biofilm Production among Staphylococci Isolated from Tertiary Care Hospitals in Nepal
Authors: Manandhar Sarita , Shrestha Raju , Tuladhar Ratna Shova , Lekhak Sunil
Published: December 2021

Resistance to antibiotics, biofilm formation and the presence of virulence factors play important roles in increased mortality associated with infection by staphylococci. The macrolide lincosamide streptogramin B (MLSB) family of antibiotics is commonly used to treat infections by methicillin-resistant isolates. Clinical failure of clindamycin therapy has been reported due to multiple mechanisms that confer resistance to MLSB. This study aims to find the incidence of different phenotypes of MLSB resistance and biofilm production among staphylococci. A total of 375 staphylococci were isolated from different clinical samples, received from two tertiary care hospitals in Nepal. Methicillin resistance was detected by cefoxitin disc diffusion method and inducible clindamycin resistance by D test, according to CLSI guidelines. Biofilm formation was detected by the tissue culture plate method and PCR was used to detect ica genes. Of the total staphylococci isolates, 161 (42.9%) were Staphylococcus aureus, with 131 (81.4%) methicillin-resistant strains, and 214 (57.1%) isolates were coagulase-negative staphylococci, with 143 (66.8%) methicillin-resistant strains. The overall prevalence of constitutive MLSB (cMLSB) and inducible MLSB (iMLSB) phenotypes was 77 (20.5%) and 87 (23.2%), respectively. Both iMLSB and cMLSB phenotypes predominated in methicillin-resistant isolates. The tissue culture plate method detected biofilm formation in 174 (46.4%) isolates and ica genes in 86 (22.9%) isolates. Among biofilm producing isolates, cMLSB and iMLSB phenotypes were 35 (20.1%) and 27 (15.5%), respectively. The cMLSB and iMLSB were 11 (12.8%) and 19 (22.1%), respectively, in isolates possessing ica genes. Clindamycin resistance in the form of cMLSB and iMLSB, especially among MRSA, emphasizes the need for routine D tests to be performed in the lab.
Neochlorogenic Acid Attenuates Hepatic Lipid Accumulation and Inflammation via Regulating miR-34a In Vitro
Authors: Yu Meng-Hsun , Hung Tung-Wei , Wang Chi-Chih , Wu Sheng-Wen , Yang Tzu-Wei , Yang Ching-Yu , Tseng Tsui-Hwa , Wang Chau-Jong
Published: December 2021

Neochlorogenic acid (5-Caffeoylquinic acid; 5-CQA), a major phenolic compound isolated from mulberry leaves, possesses anti-oxidative and anti-inflammatory effects. Although it modulates lipid metabolism, the molecular mechanism is unknown. Using an in-vitro model of nonalcoholic fatty liver disease (NAFLD) in which oleic acid (OA) induced lipid accumulation in HepG2 cells, we evaluated the alleviation effect of 5-CQA. We observed that 5-CQA improved OA-induced intracellular lipid accumulation by downregulating sterol regulatory element-binding protein 1 (SREBP1) and fatty acid synthase (FASN) expression, which regulates the fatty acid synthesis, as well as SREBP2 and HMG-CoA reductases (HMG-CoR) expressions, which regulate cholesterol synthesis. Treatment with 5-CQA also increased the expression of fatty acid β-oxidation enzymes. Remarkably, 5-CQA attenuated OA-induced miR-34a expression. A transfection assay with an miR-34a mimic or miR-34a inhibitor revealed that miR-34a suppressed Moreover, Sirtuin 1 (SIRT1) expression and inactivated 5’ adenosine monophosphate-activated protein kinase (AMPK). Our results suggest that 5-CQA alleviates lipid accumulation by downregulating miR-34a, leading to activation of the SIRT1/AMPK pathway.
PPARγ—A Factor Linking Metabolically Unhealthy Obesity with Placental Pathologies
Authors: Kwiatkowski Sebastian , Kajdy Anna , Stefańska Katarzyna , Bednarek-Jędrzejek Magdalena , Dzidek Sylwia , Tousty Piotr , Sokołowska Małgorzata , Kwiatkowska Ewa
Published: December 2021

Obesity is a known factor in the development of preeclampsia. This paper links adipose tissue pathologies with aberrant placental development and the resulting preeclampsia. PPARγ, a transcription factor from the ligand-activated nuclear hormone receptor family, appears to be one common aspect of both pathologies. It is the master regulator of adipogenesis in humans. At the same time, its aberrantly low activity has been observed in placental pathologies. Overweight and obesity are very serious health problems worldwide. They have negative effects on the overall mortality rate. Very importantly, they are also conducive to diseases linked to impaired placental development, including preeclampsia. More and more people in Europe are suffering from overweight (35.2%) and obesity (16%) (EUROSTAT 2021 data), some of them young women planning pregnancy. As a result, we will be increasingly encountering obese pregnant women with a considerable risk of placental development disorders, including preeclampsia. An appreciation of the mechanisms shared by these two conditions may assist in their prevention and treatment. Clearly, it should not be forgotten that health education concerning the need for a proper diet and physical activity is of utmost importance here.
Stage 2: Who Are the Best Candidates for Robotic Gait Training Rehabilitation in Hemiparetic Stroke?
Authors: Oh Wonjun , Park Chanhee , Oh Seungjun , You Sung (Joshua) H.
Published: December 2021

We aimed to compare the effects of robotic-assisted gait training (RAGT) in patients with FAC < 2 (low initial functional ambulation category [LFAC]) and FAC ≥ 2 (high initial functional ambulation category [HFAC]) on sensorimotor and spasticity, balance and trunk stability, the number of steps and walking distance in subacute hemiparetic stroke. Fifty-seven patients with subacute hemiparetic stroke (mean age, 63.86 ± 12.72 years; 23 women) were assigned to two groups. All patients received a 30-min Walkbot-assisted gait training session, 3 times/week, for 6 weeks. Clinical outcomes included scores obtained on the Fugl–Meyer Assessment (FMA) scale, Modified Ashworth Scale (MAS), Berg Balance Scale (BBS), trunk impairment scale (TIS), and the number of walking steps and walking distance. Analysis of covariance and analysis of variance were conducted at p < 0.05. Significant main effects of time in both groups on number of walking steps and distance (p < 0.05) were observed, but not in MAS (p> 0.05). Significant changes in FMA, BBS, and TIS scores between groups (p < 0.05) were observed. Significant main effects of time on BBS and TIS were demonstrated (p < 0.05). Our study shows that RAGT can maximize improvement in the functional score of FMA, BBS, TIS, steps, and distance during neurorehabilitation of subacute stroke patients regardless of their FAC level.
The Use of Low-Profile Angular-Stability Plates in a “Nutcracker” Tarsal Navicular Fracture Combined with a Cuboid Fracture: ORIF Experience
Authors: Quattrini Fabrizio , Ciatti Corrado , Gattoni Serena , Puma Pagliarello Calogero , Ceccarelli Francesco , Maniscalco Pietro
Published: December 2021

Background: Clear recommendations about the optimal treatment of traumatic tarsal navicular fractures are still very debated in the literature, and this is due to several factors: navicular fractures are rare and often misdiagnosed injuries, they are frequently associated with other fractures or a dislocation of the midfoot, and the current knowledge is based on few papers mainly considering a limited number of cases and dealing with different therapeutic approaches. The treatment of navicular body fractures is controversial and burdened by a high incidence of complications; in particular, Sangeorzan type III comminuted fractures represent a real challenge for the orthopedic surgeon. An accurate preoperative planning, a scrupulous surgical technique aimed at restoring volume and bony anatomy, and the use of low-profile angular-stability plates can lead to optimal clinical and functional results, decreasing the chances of arthritic evolution of mid-foot joints.
Prediction and Compensation of Color Deviation by Response Surface Methodology for PolyJet 3D Printing
Authors: Wei Xingjian , Bhardwaj Abhinav , Zeng Li , Pei Zhijian
Published: December 2021

PolyJet 3D printing can produce any color by mixing multiple materials. However, there are often large deviations between the measured color of printed samples and the target color (when the target color is used as the specified color in the printer software). Therefore, to achieve a target color on a printed sample, the specified color in the printer software should not be the same as the target color. This study applies response surface methodology (RSM) to determine the optimal color specification to compensate for color deviations of the measured color of printed samples from the target color in PolyJet 3D printing. The RSM has three steps. First, a set of experiments are designed for a target color according to central composite design. Second, the experimental data are used to develop a second-order multivariate multiple regression model to predict the deviation between the measured color and the target color. Third, the optimal color specification (often different from the target color) is determined by using the developed predictive model and the desirability function. When the optimal color specification is used as the specified color in the printer software, the deviation between the predicted color of the printed sample and the target color is minimized. The proposed method is applied to four target colors to demonstrate its effectiveness. The results show that the proposed method performs better than the conventional color specification method without compensation in achieving the four target colors by 33% on average.
Unsupervised Machine Learning for Improved Delaunay Triangulation
Authors: Song Tao , Wang Jiarong , Xu Danya , Wei Wei , Han Runsheng , Meng Fan , Li Ying , Xie Pengfei
Published: December 2021

Physical oceanography models rely heavily on grid discretization. It is known that unstructured grids perform well in dealing with boundary fitting problems in complex nearshore regions. However, it is time-consuming to find a set of unstructured grids in specific ocean areas, particularly in the case of land areas that are frequently changed by human construction. In this work, an attempt was made to use machine learning for the optimization of the unstructured triangular meshes formed with Delaunay triangulation in the global ocean field, so that the triangles in the triangular mesh were closer to equilateral triangles, the long, narrow triangles in the triangular mesh were reduced, and the mesh quality was improved. Specifically, we used Delaunay triangulation to generate the unstructured grid, and then developed a K-means clustering-based algorithm to optimize the unstructured grid. With the proposed method, unstructured meshes were generated and optimized for global oceans, small sea areas, and the South China Sea estuary to carry out data experiments. The results suggested that the proportion of triangles with a triangle shape factor greater than 0.7 amounted to 77.80%, 79.78%, and 79.78%, respectively, in the unstructured mesh. Meanwhile, the proportion of long, narrow triangles in the unstructured mesh was decreased to 8.99%, 3.46%, and 4.12%, respectively.
Fewer and Later: Women as Experts in TED Talks about COVID-19
Authors: Eizmendi Maider , Peña-Fernández Simón
Published: December 2021

The dissemination of science has undergone a major upsurge in recent years thanks to the Internet, which has served to overcome many of the technical and economic barriers. Among the many initiatives, one of the most successful tools has been the TED Talks website. At the same time, various studies indicate that women produce less science dissemination content and that they are also more likely to receive hostile comments. The objective of this research is to analyze from a gender perspective the content published on the TED Talk website on COVID-19 from 1 March 2020 to 31 March 2021 (n = 62) to determine its characteristics and the topics addressed, as well as the resulting engagement and the predominant feelings of the comments received. To do this, a content analysis of the publications has been carried out, as well as a qualitative analysis of the comments. The results indicate that the percentage of women experts on this platform is slightly lower than that of men (42.19%), and they have published content in later phases of the pandemic. From a qualitative point of view there are also differences, since women mainly opt for a social, political and social approach to the issue. In addition, the engagement of their publications is lower than that of men, although a higher prevalence of negative feelings is perceived in the comments they receive.
Analysis of Different Digital Alternatives as Teaching Tools to Improve the Teaching–Learning Process
Authors: Perez-Puyana Victor , Jiménez-Rosado Mercedes , Romero Alberto
Published: December 2021

Virtual tools are frequently used in education. Among them, the use of virtual laboratories could be an interesting alternative to strengthen the practical concepts of the students, especially in the current paradigm in which the presence of students is often not possible. For this reason, the aim of this study was to analyse the use of different digital tools for the improvement of the teaching process during the COVID-19 pandemic period. To this end, a comparison of the application of different digital alternatives was carried out, evaluating the differences found with previous teaching courses. The results indicate that, although students welcome these activities, they cannot replace face-to-face practices, being considered as a complementary activity.
The Evolution of Student Free Speech: Tinker and Beyond
Authors: Dayton John , Tarhan Betul
Published: December 2021

There are no secure rights without the right of free speech. Free speech is the right that is necessary to defend all other rights. Student free speech is an essential foundation for societal free speech. We will not have a society that values and protects free speech without valuing and protecting free speech for students. Schools must serve as the essential nurseries of our democracy and as examples of the responsible exercise of rights in a free society including free speech. We cannot expect students to spend most of their waking hours in institutions devoid of meaningful rights to freedom of speech and then emerge as adults prepared to exercise and defend democratic freedoms including free speech. Students who learn to exercise free speech rights in schools are more likely to become adults ready to exercise free speech rights in a civil democracy. This article addresses the ongoing evolution of student free speech rights in the U.S., providing a brief overview of free speech law; a review of student speech law in public K-12 schools and in public higher education institutions; a guide to applying the Tinker test in practice; a discussion of the continuing evolution of student speech law in public educational institutions; a review of freedom of the press in public educational institutions; and conclusions on the evolution of student speech.
Finite Element Analysis on Initial Crack Site of Porous Structure Fabricated by Electron Beam Additive Manufacturing
Authors: Tsai Meng-Hsiu , Yang Chia-Ming , Hung Yu-Xuan , Jheng Chao-Yong , Chen Yen-Ju , Fu Ho-Chung , Chen In-Gann
Published: December 2021

Ti6Al4V specimens with porous structures can be fabricated by additive manufacturing to obtain the desired Young’s modulus. Their mechanical strength and deformation behavior can be evaluated using finite element analysis (FEA), with various models and simulation methodologies described in the existing literature. Most studies focused on the evaluation accuracy of the mechanical strength and deformation behavior using complex models. This study presents a simple elastic model for brittle specimens followed by an electron beam additive manufacturing (EBAM) process to predict the initial crack site and threshold of applied stress related to the failure of cubic unit lattice structures. Six cubic lattice specimens with different porosities were fabricated by EBAM, and compression tests were performed and compared to the FEA results. In this study, two different types of deformation behavior were observed in the specimens with low and high porosities. The adopted elastic model and the threshold of applied stress calculated via FEA showed good capabilities for predicting the initial crack sites of these specimens. The methodology presented in this study should provide a simple yet accurate method to predict the fracture initiation of porous structure parts.
Influence of 3D Printing Topology by DMLS Method on Crack Propagation
Authors: Dvorak Karel , Dvorakova Jana , Zarybnicka Lucie , Horak Zdenek
Published: December 2021

The presented text deals with research into the influence of the printing layers’ orientation on crack propagation in an AlSi10Mg material specimen, produced by additive technology, using the Direct Metal Laser Sintering (DMLS) method. It is a method based on sintering and melting layers of powder material using a laser beam. The material specimen is presented as a Compact Tension test specimen and is printed in four different defined orientations (topology) of the printing layers—0°, 45°, 90°, and twice 90°. The normalized specimen is loaded cyclically, where the crack length is measured and recorded, and at the same time, the crack growth rate is determined. The evaluation of the experiment shows an apparent influence of the topology, which is essential especially for possible use in the design and technical preparation of the production of real machine parts in industrial practice. Simultaneously with the measurement results, other influencing factors are listed, especially product postprocessing and the measurement method used. The hypothesis of crack propagation using Computer Aided Engineering/Finite Element Method (CAE/FEM) simulation is also stated here based on the achieved results.
Experimental and Numerical Analysis of Refill Friction Stir Spot Welding of Thin AA7075-T6 Sheets
Authors: Janga Venkata Somi Reddy , Awang Mokhtar , Yamin Mohd Fadillah , Suhuddin Uceu F. H. , Klusemann Benjamin , Santos Jorge F. dos
Published: December 2021

The refill friction stir spot welding (refill FSSW) process is a solid-state joining process to produce welds without a keyhole in spot joint configuration. This study presents a thermo-mechanical model of refill FSSW, validated on experimental thermal cycles for thin aluminium sheets of AA7075-T6. The temperatures in the weld centre and outside the welding zone at selected points were recorded using K-type thermocouples for more accurate validation of the thermo-mechanical model. A thermo-mechanical three-dimensional refill FSSW model was built using DEFORM-3D. The temperature results from the refill FSSW numerical model are in good agreement with the experimental results. Three-dimensional material flow during plunging and refilling stages is analysed in detail and compared to experimental microstructure and hardness results. The simulation results obtained from the refill FSSW model correspond well with the experimental results. The developed 3D numerical model is able to predict the thermal cycles, material flow, strain, and strain rates which are key factors for the identification and characterization of zones as well for determining joint quality.
Fabrication of Millable Polyurethane Elastomer/Eucommia Ulmoides Rubber Composites with Superior Sound Absorption Performance
Authors: Dong Yuhang , Yin Dexian , Deng Linhui , Cao Renwei , Hu Shikai , Zhao Xiuying , Liu Li
Published: December 2021

Sound absorbing materials combining millable polyurethane elastomer (MPU) and eucommia ulmoides rubber (EUG) were successfully fabricated via a physical blending process of EUG and MPU. The microstructure, crystallization performances, damping, mechanical and sound absorption properties of the prepared MPU/EUG composites were investigated systematically. The microstructure surface of various MPU/EUG composites became rough and cracked by the gradual incorporation of EUG, resulting in a deteriorated compatibility between EUG and MPU. With the increase of EUG content, the storage modulus (E’) of various MPU/EUG composites increased in a temperature range of −50 °C to 40 °C and their loss factor (tanδ) decreased significantly, including a reduction of the tanδ of MPU/EUG (70/30) composites from 0.79 to 0.64. Specifically, the addition of EUG sharply improved the sound absorption performances of various MPU/EUG composites in a frequency range of 4.5 kHz–8 kHz. Compared with that of pure MPU, the sound absorption coefficient of the MPU/EUG (70/30) composite increased 52.2% at a pressure of 0.1 MPa and 16.8% at a pressure of 4 MPa, indicating its outstanding sound absorption properties.
Advancing towards a Practical Magnesium Ion Battery
Authors: Medina Alejandro , Pérez-Vicente Carlos , Alcántara Ricardo
Published: December 2021

A post-lithium battery era is envisaged, and it is urgent to find new and sustainable systems for energy storage. Multivalent metals, such as magnesium, are very promising to replace lithium, but the low mobility of magnesium ion and the lack of suitable electrolytes are serious concerns. This review mainly discusses the advantages and shortcomings of the new rechargeable magnesium batteries, the future directions and the possibility of using solid electrolytes. Special emphasis is put on the diversity of structures, and on the theoretical calculations about voltage and structures. A critical issue is to select the combination of the positive and negative electrode materials to achieve an optimum battery voltage. The theoretical calculations of the structure, intercalation voltage and diffusion path can be very useful for evaluating the materials and for comparison with the experimental results of the magnesium batteries which are not hassle-free.
Estimation of C* Integral for Mismatched Welded Compact Tension Specimen
Authors: Katinić Marko , Turk Dorian , Konjatić Pejo , Kozak Dražan
Published: December 2021

The C* integral for the compact tension (CT) specimen is calculated using the estimation equation in ASTM E1457-15. This equation was developed based on the assumption of material homogeneity and is not applicable to a welded CT specimen. In this paper, a modified equation for estimating the C* integral for a welded compact tension (CT) specimen under creep conditions is proposed. The proposed equation is defined on the basis of systematically conducted extensive finite element (FE) analyses using the ABAQUS program. A crack in the welded CT specimen is located in the center of the heat-affected zone (HAZ), because the most severe type IV cracks are located in the HAZ. The results obtained by the analysis show that the equation for estimating the C* integral in ASTM E1457-15 can underestimate the value of the C* integral for creep-soft HAZ and overestimate for creep-hard HAZ. Therefore, the proposed modified equation is suitable for describing the creep crack growth (CCG) of welded specimens.
Low-Carbon and Fundamental Properties of Eco-Efficient Mortar with Recycled Powders
Authors: Sun Chang , Chen Lulu , Xiao Jianzhuang , Liu Qiong , Zuo Junqing
Published: December 2021

Using recycled powders from solid waste is accepted as an effective strategy to realize the sustainable development of the construction industry. In our study, the cement was substituted by two kinds of recycled powders, i.e., spontaneous combustion gangue powder (SCGP) and recycled concrete powder (RCP), with a certain replacement ratio of 30%. The experimental variables were mainly the type of replacement powder (e.g., SCGP, RCP, and SCGP + RCP) and the grinding time of RCP (e.g., 25 min, 50 min, and 75 min). The fundamental properties, including mechanical properties, long-term properties, and carbon emission, were analyzed for all the mortar mixtures. Experimental results indicate that incorporation of RCP contributes to enhancing the toughness and dry shrinkage resistance of eco-efficient mortar, while SCGP positively affects the compressive strength and chloride resistance. The grinding process improves the activity of RCP to a certain extent, while a long grinding time leads to fusion and aggregation between powders. Investigation on CO2 emission demonstrates that carbon emission from cement production accounts for the largest proportion, 80~95%, in the total emission from mortar production. Combined with the AHP model, eco-efficient mortar containing 15% RCP ground for 50 min and 15% SCGP displays optimal fundamental properties.
Synaptic Transistors Exhibiting Gate-Pulse-Driven, Metal-Semiconductor Transition of Conduction
Authors: Lim Jung Wook , Heo Su Jae , Park Min A. , Kim Jieun
Published: December 2021

Neuromorphic devices have been investigated extensively for technological breakthroughs that could eventually replace conventional semiconductor devices. In contrast to other neuromorphic devices, the device proposed in this paper utilizes deep trap interfaces between the channel layer and the charge-inducing dielectrics (CID). The device was fabricated using in-situ atomic layer deposition (ALD) for the sequential deposition of the CID and oxide semiconductors. Upon the application of a gate bias pulse, an abrupt change in conducting states was observed in the device from the semiconductor to the metal. Additionally, numerous intermediate states could be implemented based on the number of cycles. Furthermore, each state persisted for 10,000 s after the gate pulses were removed, demonstrating excellent synaptic properties of the long-term memory. Moreover, the variation of drain current with cycle number demonstrates the device’s excellent linearity and symmetry for excitatory and inhibitory behaviors when prepared on a glass substrate intended for transparent devices. The results, therefore, suggest that such unique synaptic devices with extremely stable and superior properties could replace conventional semiconducting devices in the future.
Impedance Analysis and Noise Measurements on Multi Walled Carbon Nanotube Networks
Authors: Philipose Usha , Jiang Yan , Western Brianna , Harcrow Michael , Littler Chris , Sood Ashok , Zeller John W. , Lineberry Bobby , Syllaios A. J.
Published: December 2021

The electrical impedance characteristics of multi-walled carbon nanotube (MWCNTs) networks were studied as a function of CNT concentrations in the frequency range of 1 kHz–1 MHz. The novelty of this study is that the MWCNTs were not embedded in any polymer matrix and so the response of the device to electrical measurements are attributed to the CNTs in the network without any contribution from a polymer host matrix. Devices with low MWCNT packing density (0.31–0.85 µg/cm2) exhibit a frequency independent plateau in the low-frequency regime. At higher frequencies, the AC conductivity of these devices increases following a power law, characteristic of the universal dynamic response (UDR) phenomenon. On the other hand, devices with high MWCNT concentrations (>1.0 µg/cm2) exhibit frequency independent conductivity over the entire frequency range (up to 1 MHz), indicating that conduction in these devices is due to direct contact between the CNTs in the network. A simple single-relaxation time electrical equivalent circuit with an effective resistance and capacitance is used to describe the device performance. The electrical noise measurements on devices with different MWCNT packing densities exhibit bias-dependent low-frequency 1/f noise, attributed to resistance fluctuations.
The Yield of Endoscopy and Histology in the Evaluation of Esophageal Dysphagia: Two Referral Centers’ Experiences
Authors: Mari Amir , Abu Baker Fadi , Said Ahmad Helal , Omari Ali , Jawabreh Yazed , Abboud Rand , Shahin Amir , Shibli Fahmi , Sbeit Wisam , Khoury Tawfik
Published: December 2021

Background and Objectives: The initial diagnostic test required to evaluate esophageal dysphagia is upper endoscopy (EGD) to assess the structure of the esophagus and the esophageo-gastric junction (EGJ). Taking biopsies during EGD has become a common practice in patients with dysphagia to rule out eosinophilic esophagitis (EoE). The aims of this study were to evaluate the endoscopic findings of patients who underwent EGD for esophageal dysphagia, to assess the rate of biopsy taking from the esophagus to diagnose/exclude EoE, and to report histology outcomes of these biopsies. Materials and Methods: This was a retrospective multicenter study that included individuals ≥18 years who underwent EGD due to esophageal dysphagia between the years 2015 and2020, (with no other alarm signs, such as weight loss, new iron deficiency anemia, and lymphadenopathy). We obtained data from patients’ electronic files. The endoscopy and histology findings were obtained from endoscopy reports saved in our electronic files. Results: A total of 209 patients were included in the study. The average age was 57.1 ± 17.1 years. The most common endoscopic findings were normal endoscopy in 76 patients (36.4%) and erosive esophagitis in 75 patients (35.9%). Barrett’s esophagus and esophageal malignancy were encountered in 11 patients (5.3%) and 2 patients (0.95%), respectively. Esophageal biopsies were taken in 50.2% of patients, and one patient had histological evidence of EoE (0.5%). On univariate analysis, there was a trend for association between proton pump inhibitors (PPIs) use and a normal EGD, but it was not statistically significant (OR 0.28, 95% CI 0.07–1.11, p = 0.07). Conclusions: Endoscopic findings were prevalent in dysphagia patients even when no other alarm symptoms exist. Neoplastic lesions and EOE were rare in our study.
Digital Representation of Measurement Uncertainty: A Case Study Linking an RMO Key Comparison with a CIPM Key Comparison
Authors: Hall Blair D. , Koo Annette
Published: December 2021

This paper considers a future scenario in which digital reporting of measurement results is ubiquitous and digital calibration certificates (DCCs) contain information about the components of uncertainty in a measurement result. The task of linking international measurement comparisons is used as a case study to look at the benefits of digitalization. Comparison linking provides a context in which correlations are important, so the benefit of passing a digital record of contributions to uncertainty along a traceability chain can be examined. The International Committee for Weights and Measures (CIPM) uses a program of international “key comparisons” to establish the extent to which measurements of a particular quantity may be considered equivalent when made in different economies. To obtain good international coverage, the results of the comparisons may be linked together: a number of regional metrology organization (RMO) key comparisons can be linked back to an initial CIPM key comparison. Specific information about systematic effects in participants’ results must be available during linking to allow correct treatment of the correlations. However, the conventional calibration certificate formats used today do not provide this: participants must submit additional data, and the report of an initial comparison must anticipate the requirements for future linking. Special handling of additional data can be laborious and prone to error. An uncertain-number digital reporting format was considered in this case study, which caters to all the information required and would simplify the comparison analysis, reporting, and linking; the format would also enable a more informative presentation of comparison results. The uncertain-number format would be useful more generally, in measurement scenarios where correlations arise, so its incorporation into DCCs should be considered. A full dataset supported by open-source software is available.
Large Geographical Area Aerial Surveillance Systems Data Network Infrastructure Managed by Artificial Intelligence and Certified over Blockchain: A Review
Authors: Batista Nelson , Melicio Rui , Santos Luis Filipe
Published: December 2021

This paper proposes an aerial data network infrastructure for Large Geographical Area Surveillance Systems. The work presents a review of previous works from the authors, existing technologies in the market, and other scientific work, with the goal of creating a data network supported by Autonomous Tethered Aerostat Airships used for sensor fixing, a drones deployment base, and meshed data network nodes installation. The proposed approach for data network infrastructure supports several independent and heterogeneous services from independent, private, and public companies. The presented solution employs Edge Artificial Intelligence (AI) systems for autonomous infrastructure management. The Edge AI used in the presented solution enables the AI management solution to work without the need for a permanent connection to cloud services and is constantly fed by the locally generated sensor data. These systems interact with other network AI services to accomplish coordinated tasks. Blockchain technology services are deployed to ensure secure and auditable decisions and operations, which are validated by the different involved ledgers.
Role of NK Cells in Cancer and Immunotherapy
Authors: Vishwasrao Paresh , Hui Susanta K. , Smith D. Lynne , Khairnar Vishal
Published: December 2021

Increasing knowledge of cancer immunology has led to the design of therapies using immune cells directly or manipulating their activity, collectively termed immunotherapy. In the field of immuno-oncology, research on adaptive immune T cells has led to the development of CAR-T cells. Innate immune cells such as NK cells can also eliminate oncogenically transformed cells and regulate cells of the immune system. Considering NK cells as a live drug, numerous methods for the isolation and activation of NK cells have been shown to be clinically and therapeutically relevant. In such processes, various cytokines and antibodies present a source of stimulation of NK cells and enhance the efficacy of such treatments. The ex vivo expansion and activation of NK cells, along with genetic modification with CAR, enhance their antitumor activity. Recent preclinical studies have shown an antitumor effect through extracellular vesicles (EVs) derived from NK cells. Work with autologous NK cells has provided insights for clinical applications. In this review, we outline the recent advances of NK-cell-based immunotherapies, summarizing CAR-NK cells, BiKEs, and TriKEs as treatment options against cancer. This review also discusses the challenges of NK cell immunotherapy.
Oxacillin (Methicillin) Resistant Staphylococci in Domestic Animals in the Czech Republic
Authors: Bzdil Jaroslav , Zouharova Monika , Nedbalcova Katerina , Sladecek Vladimir , Senk David , Holy Ondrej
Published: December 2021

The aim of this study was to describe the prevalence of different Staphylococcus species isolated from pathological processes and lesions in domestic animals in the Czech Republic and to detect and describe oxacillin (methicillin)-resistant strains (MRS). During the years 2019–2020, a total of 5218 veterinary clinical samples from the Czech Republic were tested. Testing was performed by culture methods and typing by molecular phenotypic methods MALDI-TOF MS and PCR. Antimicrobial susceptibility testing of the strains was performed by the disk diffusion method. A total of 854 staphylococci strains were identified (16.37% prevalence), out of which 43 strains of 6 species of staphylococci were MRS (n = 43; 0.82% prevalence). Of the MRS strains, the most prevalent species were Staphylococcus pseudintermedius (n = 24; 0.46% prevalence) and Staphylococcus aureus (n = 7; 0.13% prevalence). Susceptibility testing showed resistance to beta-lactam antibiotics and, depending on the species, also to trimethoprim/sulfamethoxazole, gentamicin, tetracycline, erythromycin, clindamycin, and enrofloxacin. For further characterization of MRS, PCR assay for virulence factor genes was performed. Seven of the 14 target genes were observed only in S. aureus, except for the eno gene encoding laminin-binding protein, which was also detected in other staphylococci. It is necessary to emphasize the issue of correct using of antimicrobials in practice and antibiotic policy in university teaching and to create stricter legislation that would prevent the widespread use of antimicrobials in veterinary medicine, especially in livestock to reduce the emergence and spread of antimicrobial resistance.
Extending the Cultivation Period of Undaria pinnatifida by Using Regional Strains with Phenotypic Differentiation along the Sanriku Coast in Northern Japan
Authors: Sato Yoichi , Hirano Tomonari , Ichida Hiroyuki , Fukunishi Nobuhisa , Abe Tomoko , Kawano Shigeyuki
Published: December 2021

The Sanriku district is one of the largest Undaria pinnatifida (Wakame) cultivation areas in Japan. However, the production has steadily declined in recent years due to the high retirement rate among fishers. Extending the cultivation period is a potential way to improve productivity by decentralizing the workforce through the production process. We aimed to investigate the phenotypic differentiation between regional strains of U. pinnatifida collected from Matsushima Bay (MAT) and Hirota Bay (HRT) in the Sanriku district through a cultivation trial to verify the application for the purpose of extending the cultivation period. The growth of MAT was better than that of HRT when the cultivation started earlier (i.e., 9 and 19 October 2014); in contrast, HRT outperformed MAT when the cultivation started later (6 November and 12 December 2014). The yield of MAT reached over the standard amount in the Sanriku district in February. On the other hand, the yield of HRT reached over this value in April. Furthermore, the photosynthetic performance and nutrient uptake rates differed between MAT and HRT, indicating that the differences may result in maturation characteristics. According to these results, the combined use of MAT and HRT would be a valuable strategy by which to extend the cultivation period.
Single-Chamber Microbial Fuel Cell with Multiple Plates of Bamboo Charcoal Anode: Performance Evaluation
Authors: Sato Chikashi , Paucar N. Evelin , Chiu Steve , Mahmud Muhammad Z. I. M. , Dudgeon John
Published: December 2021

In this study, three single-chamber microbial fuel cells (MFCs), each having Pt-coated carbon cloth as a cathode and four bamboo charcoal (BC) plates as an anode, were run in a fed-batch mode, individually and in series. Simulated potato-processing wastewater was used as a substrate for supporting the growth of a mixed bacterial culture. The maximum power output increased from 0.386 mW with one MFC to 1.047 mW with three MFCs connected in series. The maximum power density, however, decreased from 576 mW/m2 (normalized to the cathode area) with one MFC to 520 mW/m2 with three MFCs in series. The experimental results showed that power can be increased by connecting the MFCs in series; however, choosing low resistance BC is crucial for increasing power density.
Gender and Pan-Species Democracy in the Anthropocene
Authors: Strang Veronica
Published: December 2021

There are diverse historical trajectories in human societies’ relationships with the non-human world. While many small place-based groups have tried to retain egalitarian partnerships with other species and ecosystems, larger societies have made major transitions. In religious terms, they have moved from worshipping female, male or androgynous non-human deities, to valorising pantheons of deities that, over time, became semi-human and then human in form. Reflecting Durkheimian changes in social and political arrangements, movements towards patriarchy led to declining importance in female deities, and the eventual primacy of single male Gods. With these changes came dualistic beliefs separating Culture from Nature, gendering these as male and female, and asserting male dominion over both Nature and women. These beliefs supported activities that have led to the current environmental crisis: unrestrained growth; hegemonic expansion; colonialism, and unsustainable exploitation of the non-human world. These are essentially issues of inequality: between genders, between human groups, and between human societies and other living kinds. This paper draws on a series of ethnographic research projects (since 1992) exploring human-environmental relationships, primarily in Australia, the UK, and New Zealand, and on a larger comparative study, over many years, of a range of ethnographic, archaeological, theological, and historical material from around the world. It considers contemporary debates challenging Nature-Culture dualism and promoting ‘rights for Nature’ or—rejecting anthropocentricity to recognize an indivisible world—for the non-human communities with whom we co-inhabit ecosystems. Proposing new ways to configure ethical debates, it suggests that non-human rights are, like women’s rights, fundamentally concerned with power relations, social status, and access to material resources, to the extent that the achievement of ‘pan-species democracy’ and greater equality between living kinds goes hand-in-hand with social, political and religious equality between genders.
Hybrid Random Forest and Support Vector Machine Modeling for HVAC Fault Detection and Diagnosis
Authors: Tun Wunna , Wong Johnny Kwok-Wai , Ling Sai-Ho
Published: December 2021

The malfunctioning of the heating, ventilating, and air conditioning (HVAC) system is considered to be one of the main challenges in modern buildings. Due to the complexity of the building management system (BMS) with operational data input from a large number of sensors used in HVAC system, the faults can be very difficult to detect in the early stage. While numerous fault detection and diagnosis (FDD) methods with the use of statistical modeling and machine learning have revealed prominent results in recent years, early detection remains a challenging task since many current approaches are unfeasible for diagnosing some HVAC faults and have accuracy performance issues. In view of this, this study presents a novel hybrid FDD approach by combining random forest (RF) and support vector machine (SVM) classifiers for the application of FDD for the HVAC system. Experimental results demonstrate that our proposed hybrid random forest–support vector machine (HRF–SVM) outperforms other methods with higher prediction accuracy (98%), despite that the fault symptoms were insignificant. Furthermore, the proposed framework can reduce the significant number of sensors required and work well with the small number of faulty training data samples available in real-world applications.
Validation of a Novel Wearable Multistream Data Acquisition and Analysis System for Ergonomic Studies
Authors: Ascari Luca , Marchenkova Anna , Bellotti Andrea , Lai Stefano , Moro Lucia , Koshmak Konstantin , Mantoan Alice , Barsotti Michele , Brondi Raffaello , Avveduto Giovanni , Sechi Davide , Compagno Alberto , Avanzini Pietro , Ambeck-Madsen Jonas , Vecchiato Giovanni
Published: December 2021

Nowadays, the growing interest in gathering physiological data and human behavior in everyday life scenarios is paralleled by an increase in wireless devices recording brain and body signals. However, the technical issues that characterize these solutions often limit the full brain-related assessments in real-life scenarios. Here we introduce the Biohub platform, a hardware/software (HW/SW) integrated wearable system for multistream synchronized acquisitions. This system consists of off-the-shelf hardware and state-of-art open-source software components, which are highly integrated into a high-tech low-cost solution, complete, yet easy to use outside conventional labs. It flexibly cooperates with several devices, regardless of the manufacturer, and overcomes the possibly limited resources of recording devices. The Biohub was validated through the characterization of the quality of (i) multistream synchronization, (ii) in-lab electroencephalographic (EEG) recordings compared with a medical-grade high-density device, and (iii) a Brain-Computer-Interface (BCI) in a real driving condition. Results show that this system can reliably acquire multiple data streams with high time accuracy and record standard quality EEG signals, becoming a valid device to be used for advanced ergonomics studies such as driving, telerehabilitation, and occupational safety.