bluuebunny/crossref_metadata_2025 huggingface dataset:
The efficacy and safety of combined ipilimumab and nivolumab versus ipilimumab in patients with Stage III/IV unresectable melanoma
Authors: Zhu Yuqing , Cheng Hui , Zhong Minhong , Hu Yijie , Li Qiushuang , Gao Xiangfu , Liu Shan
Published: March 2022

Background:

In this meta-analysis, we compared the clinical efficacy and safety of ipilimumab/nivolumab combination therapy with those of ipilimumab monotherapy for stage III/IV unresectable melanoma.

Materials and Methods:

A search for randomized controlled trials (RCTs) reported by relevant studies conducted up to May 2021 was performed in the PubMed, Cochrane Library, Embase, CNKI, Wanfang, and VIP databases. Literature screening, data extraction, and quality evaluation were conducted independently by two researchers. The target parameters were complete response (CR), partial response (PR), objective response rate (ORR), time to progression (TTP), overall survival (OS), adverse events (AEs), and AEs in each organ system.

Results:

Ten articles reporting the results of three RCTs, including 790 subjects, were evaluated. In the pooled results, the CR (risk ratio [RR] = 4.48, 95% confidence interval [CI] [2.73, 7.33]), PR (RR = 2.82, 95% CI [2.09, 3.81]), and ORR (RR=3.31, 95%CI[2.60, 4.20]) were statistically different between the two treatment groups. The CR, PR, and ORR in the combination therapy group were 22.00% (90/409), 36.43% (149/409), and 58.44% (239/409), respectively, versus 4.97% (18/362), 12.98% (47/362), and 17.96% (65/362), respectively, in the monotherapy group. There were significant differences in TTP and OS between the two groups (TTP: hazard ratio [HR] = 0.41, 95% CI [0.35, 0.49]; OS: HR = 0.55, 95% CI [0.45, 0.67]). PFS and OS were longer in the combination therapy group than in the monotherapy group. The incidence of treatment-related AEs (TRAEs) and AEs leading to death (RR = 1.00, 95% CI [0.97, 1.02]; RR = 2.28, 95% CI [0.54, 9.55], respectively) was not significantly different, but the incidence of Grade 3-4 AEs and AEs leading to discontinuation was higher in the combination therapy group than in the monotherapy group (RR = 1.81, 95% CI [1.15, 2.86]); RR = 2.66, 95% CI [2.02, 3.52], respectively).

Conclusions:

Ipilimumab/nivolumab combination therapy was more effective than ipilimumab monotherapy for patients with stage III/IV unresectable melanoma. Although the incidence of TRAEs did not differ between the two groups, the severity of cases (Grade 3–4 AEs and AEs leading to discontinuation) was lower in the monotherapy group than in the combination therapy group. Additional high-quality studies are needed to verify the efficacy and safety of this drug combination, determine the optimal dosage, and explore additional potential drug combinations.
High systemic immune-inflammation index is a predictor of poor prognosis in patients with nonsmall cell lung cancer and bone metastasis
Authors: Xu Shanqi , Cao Shoubo , Yu Yan
Published: March 2022

Aim:

This study aimed to evaluate whether systemic immune inflammation (SII) is correlated with overall survival (OS) in patients with nonsmall cell lung cancer (NSCLC) and bone metastasis.

Settings and Design:

This was a retrospective analysis of the value of pretreatment SII in patients with NSCLC and bone metastasis.

Subjects and Methods:

Two hundred and thirty-four patients with pathologically confirmed NSCLC and bone metastasis treated at Harbin between January 2008 and May 2010 were included. Baseline clinical characteristics and pretreatment SII were collected for further analysis.

Statistical Analysis Used:

Receiver operating characteristic curve analysis was used to calculate the optimal cutoff value for SII. Survival analysis was performed using the Kaplan–Meier method. Factors associated with OS were identified by univariate and multivariate analyses.

Results:

The optimal cutoff value for pretreatment SII was 618.3 × 109/L. Pretreatment SII ≥618.3 × 109/L was more commonly seen in patients with a greater number of distant metastases (<2 vs. ≥2, 56.4% vs. 70.0%, P = 0.033). Univariate analysis showed that sex, tumor histology, Eastern Cooperative Oncology Group-Performance Status (ECOG-PS) score, pretreatment SII, and systemic chemotherapy were associated with OS (P < 0.05). Multivariate analysis showed that sex (hazard ratio [HR] = 1.349, 95% confidence interval [CI] = 1.029-1.708, P = 0.030), ECOG-PS (HR = 1.674, 95% CI = 1.256–2.232, P < 0.001), SII (HR = 1.456, 95% CI = 1.100–1.927, P = 0.009), and systemic chemotherapy (HR = 0.596, 95% CI = 0.437–0.813, P = 0.001) were independent prognostic factors. Subgroup analyses found that SII was prognostic for patients with the following characteristics: age <65 years (P = 0.002), female (P = 0.021), nonsmoker (P = 0.010), histology of adenocarcinoma (P = 0.022), ECOG-PS <2 (P = 0.013), two or more distant metastases (P = 0.004), and two or more bone metastases (P = 0.009).

Conclusions:

Pretreatment SII may be a prognostic biomarker for NSCLC and bone metastasis.
Induction plus adjuvant chemotherapy, combined treatment with nimotuzumab, and intensity-modulated radiation therapy for N3 stage nasopharyngeal carcinoma
Authors: Zhou Liya , Lin Jie , Chen Jiawei , Zhang Shuai
Published: March 2022

Context:

The main cause of treatment failure in NPC is distant metastasis and the NPC patients with stage N3 are the most prone to develop distant metastases. Thus, the selection of an efficient, lowtoxicity, welltolerated, adequate regimen is the key to improve the therapeutic efficacy for patients with stage N3 NPC.

Aims:

This study aimed to determine the safety and feasibility of induction chemotherapy with nanoparticle albumin-bound paclitaxel (nab-paclitaxel) plus cisplatin, combined treatment with nimotuzumab, and Intensity-modulated radiation therapy (IMRT), followed by S-1 adjuvant chemotherapy for stage N3M0 nasopharyngeal carcinoma (NPC).

Settings and Design:

This retrospective study involved 43 patients with stage N3M0 NPC treated with the above regimens.

Subjects and Methods:

For induction chemotherapy, four cycles of nab-paclitaxel (260 mg/m2, day 1) plus cisplatin (25 mg/m2, days 1–3) were administered. IMRT was performed concurrently with targeted therapy with nimotuzumab (200 mg IV, weekly for seven courses). For adjuvant chemotherapy, S-1 (40–60 mg twice a day, depending on the patient's body surface area) was administered for 14 days and was stopped for 7 days; this cycle was repeated every 21 days.

Statistical Analysis Used:

All statistical analyses were performed using an SPSS v21.0 software package. The LRC, OS, DMFS, and progressionfree survival (PFS) rates were calculated using the Kaplan–Meier method, and differences in these rates were analyzed using logrank test.

Results:

The total treatment efficiency was 100.0%. The 3-year locoregional control, overall survival, distant metastasis-free survival, and progression-free survival rates were 97.6%, 87.6%, 83.5%, and 81.0%, respectively. Neutropenia was the most common hematological toxicity (95.3%), and the incidence of Grade ≥3 neutropenia was 30.2%. Grade 3 anemia and thrombocytopenia did not occur. The most common nonhematological adverse reactions were mucositis (100.0%), hair loss (100.0%), rashes (65.1%), and limb numbness with pain (60.4%). The occurrence and treatment of skin rashes needed special attention.

Conclusions:

Induction nab-paclitaxel plus cisplatin, nimotuzumab combined with IMRT, followed by S-1 adjuvant chemotherapy, yielded an excellent survival benefit with tolerable toxicities in patients with stage N3 NPC. Distant metastasis was the main cause of treatment failure.
Standalone titanium/polyetheretherketone interbody cage for anterior lumbar interbody fusion
Authors: Mobbs Ralph J. , Amin Tajrian , Phan Kevin , Al Khawaja Darweesh , Choy Wen Jie , Parr William C.H. , Lovric Vedran , Walsh William R.
Published: March 2022

Context:

Anterior lumbar interbody fusion (ALIF) is a common procedure for patients suffering degenerative, deformity, or posttraumatic pathologies of the lumbar spine.

Aims:

The aim of this study is to evaluate the clinical and radiological outcomes of a combination Titanium/Polyetheretherketone (Ti/PEEK) 3-screw fixation ALIF cage.

Settings and Design:

This was a prospective multisurgeon series of 87 patients (105 implants), with a minimum 24-month follow-up. Twelve patients (12/87) were supplemented with posterior percutaneous pedicle screw fixation for additional stability for pars defect spondylolisthesis correction. Radiological follow-up with fine-cut computed tomography (CT) scan occurred at 4–6 months, and again at 18–24 months if no fusion observed on initial CT, was performed to evaluate early and final fusion rates, and integration of the Ti/PEEK cage at the end-plate junction. Clinical follow-up included the subjective measures of pain and functional status and objective wearable device monitoring.

Results:

The fusion rate was 85% (97/105 implants) 6 months postoperatively, with no implant-related complications, and 95% at 24 months, based on independent radiological assessment. Patients experienced statistically significant improvement in subjective pain and functional outcomes compared to preoperative status. The objective measures revealed a daily step count with a 27% improvement, and gait velocity with a mean increase from 0.97 m/s to 1.18 m/s, at 3 months postoperatively.

Conclusions:

A Ti/PEEK cage, with allograft and bone morphogenetic protein-2 (BMP-2), achieved rapid interbody progression to fusion and is an effective implant for use in anterior lumbar surgery with high early fusion rates and no peri-endplate lucency. Supercritical CO2 allograft provided an osteoconductive scaffold and combined well with BMP-2 to facilitate fusion.
Comparison of in vivo kinematic and radiological parameters of three cervical disc prostheses
Authors: Chang Nicholas , Mobbs Ralph , Hui Nicholas , Lin Henry
Published: March 2022

Introduction:

Cervical total disc replacement (CTDR) is an alternative to anterior cervical discectomy and fusion for select patients that may preserve range of motion and reduce adjacent segment disease. Various CTDR prostheses are available; however, comparative data are limited. This study aimed to compare the short-term kinematic and radiological parameters of the M6-C, Mobi-C, and the CP-ESP prostheses.

Methods:

This retrospective cohort study included patients treated with CTDR between March 2005 and October 2020 at a single institution. Patients were included if their follow-up assessment included lateral erect and flexion/extension radiographs. The primary outcome assessed at 3-months postoperatively was range of motion, measured by the difference in functional spinal unit angle between flexion and extension.

Results:

A total of 131 CTDR levels (120 patients, 46.2 ± 10.1 years, 57% male) were included. Prostheses implanted included the M6-C (n = 52), Mobi-C (n = 54), and CP-ESP (n = 25). Range of motion varied significantly (8.2° ± 4.4° vs. 10.9° ± 4.7° vs. 6.1° ± 2.7°, P < 0.001). On post hoc analysis, the Mobi-C prosthesis demonstrated a significantly greater range of motion than either the M6-C prosthesis (P = 0.003) or CP-ESP (P < 0.001).

Conclusion:

Although the optimal range of motion for CTDR has not been established, short-term differences in the range of motion may guide the selection of CTDR prosthesis. Further studies with longer follow-up and consideration of clinical outcome measures are necessary.
Achieving Compliance with RTCA DO-254/EUROCAE ED-80 Design Assurance Guidance for Airborne Electronic Hardware: Quality Management Perspective
Authors: Toker Banu , Katilmis Tufan Taylan
Published: March 2022

RTCA DO-254/ EUROCAE ED-80 “Design Assurance Guidance for Airborne Electronic Hardware” is a widely accepted industry standard to ensure safety in avionics hardware. FAA and EASA have recognized DO-254 as an acceptable means of compliance with the applicable airworthiness regulations for the electronic hardware. While microprocessor based complex hardware utilization in safety critical avionic hardware are increasing and DO-254 compliance is mandated by the certification authorities, development of DO-254 compliant or safety certifiable hardware is becoming more and more important and provides competitive advantage in the industry. The avionics manufacturers need to correlate their existing processes and procedures with DO-254 in order to satisfy DO-254 objectives in their own quality management system structure, which may be challenging and tricky. In this paper, complementary overview of DO-254 framework and guidance on realization of DO-254 objectives in the organization’s Quality Management System are provided. This paper is intended to help airborne electronic hardware equipment developers, integrators and subcontractors to assess typical impacts of DO-254 compliance requirements on their existing Quality Management System. DO-254 framework and objectives are elaborated, the recent supplementary clarifications and updates defined in EASA AMC 20-152A and their impact on DO-254 compliance are discussed. The diverging expectations from different Design Assurance Levels (DAL A to DAL D) are provided. Practical application recommendations are provided to illustrate the implementation of DO-254 from Quality Management System perspective. This paper researches on how to implement DO-254 and how to update company specific process and procedures to support DO-254 certifiable electronic hardware development.
Experimental Analysis of Double Pipe Heat Exchanger with V-cut Twisted Tape Inserts using PCM Dispersed Nanofluids
Authors: Singh S.K. , Kumar A. , Singh P. , Ansu A.K.
Published: March 2022

The performance of a double tube heat exchanger with V-cut twisted tape inserts (VCTT) and phase change material (PCM) dispersed nanofluid is investigated experimentally. The three water-based Al2O3, PCM, and Al2O3+PCM nanofluid with different concentrations (0.01-0.1% vol.) are used. The impacts of different geometric parameters, i.e., twist ratio (TR), depth ratio (DR) and width ratio (WR) of VCTT inserts on Nusselt number (Nu), friction factor (f) and entropy generation are examined. The outcomes expose that Nu and f increase as particle concentration increases and twisting ratio decreases. A higher Nu and f are generated by a higher DR or a lower WR. In all cases, the entropy generation of nanofluid is found to be lower than that of water. For all working fluids, a rise in TR, a fall in DR, and a rise in WR increases overall entropy generation.
Performance and Experimental Analysis of Al-Al2O3 Metal Matrix Composites
Authors: Gurusamy P. , Muthuraman V. , Hari Krishna Raj S. , Lokesh Kumar J.
Published: March 2022

Automobiles are using heavy materials which reduce mechanical efficiency, thermal efficiency and fuel consumption are increasing vice versa. To overcome these issues composite materials have been used as an alternative material in all the manufacturing sectors. Because composites have high strength, stiffness, and a very low coefficient of thermal expansion, which are recommended for structural applications. The behaviour of materials is based on the selection of matrix materials and reinforcements. Hence the selection of matrix and reinforcements play a vital role in the fabrication of composites. In this paper, Aluminium has been taken as matrix material and Al2O3 is taken as reinforcement (5%). Matrix material (Aluminium) has got very good physical and chemical properties but the toughness is moderate similarly the reinforcement (Al2O3) has got poor electrical conductivity. Fabrication of this combination would yield a better result. In this paper, the investigations of 690,740,790 and 840° C melting temperature of Aluminum Alloy A356 was carried out and its effects were studied. The best-resulted sample is taken for the microstructural analysis with various magnifications.
Performance Enhancement of Solar Air Heater using Graphene/Cerium Oxide and Graphene-Black Paint Coating on Roughened Absorber Plate
Authors: Kumar Rahul , Verma Sujit Kumar , Mishra Shri Krishna , Sharma Abhishek , Yadav Anil Singh , Sharma Neeraj
Published: March 2022

A coating on the roughened absorber surface of a solar air heater can improve its efficacy. This paper presents the results of a comparative study of nanomaterial and hybrid nanomaterial coatings on the roughened absorber surface to improve the performance of a solar air heater. The solar heater is designed to assess heat transfer rate, thermal efficiency, exergy efficiency and entropy production. To improve heat absorption, roughened absorber plates were covered with graphene and graphene/cerium oxide -black paint doped into black paint in the quantity of 1% nanomaterial. For constant air mass flow rates of 0.019 kg/s, the results are displayed. When the solar intensity is between 700 and 1250 W/m2, the thermal and exergy efficiency of the graphene/cerium oxide -black paint coating on the SAH roughened absorber plate is 3.36 % and 0.54 % respectively, greater than that of a graphene-black paint coating. For graphene-black paint, entropy generation is larger, whereas for1 % graphene/cerium oxide -black paint, it is lower.
Prevalence of os acromiale in an indigenous East African population: a computerized tomography scan-based study
Authors: Atinga Mordicai , Baraza Njalalle , Wambui Sarah , Thiong’o Wachira Joseph , Atinga Angela
Published: March 2022

Background: Failure of fusion to any of the acromion physes at maturity may lead to an os acromiale. A radiological review into the prevalence of os acromiale in an indigenous East African population was performed using computer tomography (CT) imaging. The study aimed to demonstrate a lower prevalence of os acromiale in an urban population compared with cadaveric studies.

Methods: This was a cross-sectional study with consecutive sampling. CT scans of both shoulders obtained for non-shoulder pathology were used for the analysis. CT scanning was performed at a tertiary referral hospital from January 2019 to July 2020.

Results: Nine hundred eighty-two CT studies were eligible for the review. There were148 os acromiale identified that were either pre-acromiale or meso-acromiale. The study found a 15% prevalence of os acromiale among an ethnic East African population, of which almost 40% were meso-acromiale and 60% were pre-acromiale, with no meta-acromiale.

Conclusion: The prevalence of os acromiale found in this study is similar to that observed in earlier cadaveric studies.
Comparing Concepts of God: Translating God in the Chinese and Yoruba Religious Contexts
Authors: Rouyan G.U.
Published: March 2022

This article discusses the concept of God with a focus on the translation of God in the Chinese and Yoruba religious contexts. Translating the word God is of the essence when comparing concepts of god(s). The translation of the Christian God as Olodumare misrepresents the latter. As suggested by Africanists, there should be appropriate translations for God, Olodumare, and other African gods. As a preliminary comparative attempt, this article presents a case on the introduction of God to the Chinese people. The translation of God into Chinese reflects different views regarding the correlation between the Christian God and the Chinese gods.
Estrés post-traumático en la atención de emergencias y rescates
Authors: Acuña Conejero Stephanie Sofía , Aguado Márquez Nerea María , Álvarez Casado Jorge , Amores Tola Rebeca
Published: March 2022

Introducción: Los trabajadores de emergencias están expuestos a situaciones potencialmente traumáticas, por lo que sería de interés evidenciar si existe relación entre dichos profesionales y el Trastorno de Estrés Postraumático (TEPT). Nuestro objetivo es conocer si existe evidencia de relación causal entre el desarrollo de TEPT y ser profesional de rescate, además de identificar factores de vulnerabilidad asociados e intervenciones preventivas y terapéuticas eficaces.

Método: Revisión sistemática mediante búsquedas bibliográficas en MEDLINE en bases de datos PUBMED, SCOPUS, EMBASE, WOS, Cochrane Library Plus, IBECS, LILACS y CISDOC, usando términos MeSH «emergency responders» y «stress disorder, post-traumatic». Se aplicaron estándares de calidad CONSORT, STROBE y comprobamos la evidencia mediante el sistema SIGN.

Resultados: Se seleccionaron 6 ECA (n=783) y 1 estudio de cohortes históricas (n=4487). Se describen como factores de riesgo más frecuentes: sexo femenino 2.93(1.42-6.07), diagnóstico de depresión o ansiedad 4.72(2.33-9.57) en cronicidad y abuso de sustancias 5.12(2.62-9.97) en empeoramiento del TEPT. No hay mejoras en las intervenciones preventivas (p=0.712-0.749) y (p=0.246-0.881). En 2 ECA se evidenció una reducción en la gravedad de los síntomas del TEPT mediante Terapia Cognitivo Conductual (TCC) (p=0.001 y 0.05). Existen 2 ECA con oxitocina que revelan impacto en regiones neurales para gestión emocional (p=0.0024-0.044).

Conclusiones: Existe relación causal entre el TEPT y los trabajadores de emergencias (evidencia 2+). Como tratamiento, la TCC resulta efectiva para la reducción de síntomas de TEPT (evidencia 1+). Se mostraron como principales los factores de vulnerabilidad antes mencionados (evidencia 1+). La oxitocina mostró evidencia como aliado terapéutico (evidencia 1+).
Mathematical Modeling of Large Forest Fires Initiation and Spread
Authors: Perminov V. A.
Published: March 2022

It is presented mathematical model for description of heat and mass transfer processes at crown and large forest fires initiation and spread, taking into account their mutual influences. Mathematical model of forest fire was based on an analysis of experimental data and using concepts and methods from reactive media mechanics. The paper suggested in the context of the general mathematical model of forest fires give a new mathematical setting and method of numerical solution of a problem of a forest fire modeling. The boundary-value problem is solved numerically using the control volume methods and method of splitting according to physical processes. In this context, a study - mathematical modeling - of the conditions of forest fire initiation and spreading that would make it possible to obtain a detailed picture of the change in the velocity, temperature and component concentration fields with time, and determine as well as the conditions of forest fires initiation and spread is of interest.
A Field Experience without the Field: A Reflective Self-study of Teaching an Elementary Science Field Experience Online During a Pandemic
Authors: Perry Spencer Byron , Park Rogers Meredith , Kitts Kraig
Published: March 2022

Teaching a field experience course during a pandemic resulted in unique challenges because preservice teachers could not visit classrooms like they would in a traditional field experience. This article is a self-study exploration of the tensions experienced by a doctoral student teaching an elementary math and science field experience in a fully online setting during the height of the COVID-19 pandemic. To substitute for a lack of available elementary school children, preservice teacher acted as substitutes for children during lesson rehearsals. Preservice teachers were usually poor substitutes for actual children when evaluating the extent to which the pandemic field experience mimicked traditional field experience. Instructional videos were frequently used in an attempt to provide meaningful opportunities for preservice teachers to engage in classroom practices. The perceived usefulness of instructional videos by preservice videos varied based on the type of video that was used.
The Development of Electronic Teaching Module for Implementation of Project-Based Learning during the Pandemic
Authors: Maksum Hasan , Purwanto Wawan
Published: March 2022

The quality of learning must be continuously improved, even during the pandemic. The demand is that students can study well and improve their cognitive, affective, and psychomotor skills. During the COVID-19 pandemic, students are encouraged to learn online from home. Adapting this new habit challenges the teacher to design a project-based learning process appropriately. The purpose of this paper is to describe the development process of the electronic teaching module for students as project-based learning (PjBL) of steering, brakes, and suspension subjects in the Automotive Department, Engineering Faculty, Universitas Negeri Padang. Student modules are designed to improve cognitive, affective, and psychomotor abilities. This study describes the module arrangement and uses the RD method. To investigate the needs of the development process, a need analysis was also performed. In the module development process, conceptual module and content validity were assessed by experts. Furthermore, practicality, effectiveness, and t-test were applied. The results showed that the development improves students' cognitive, affective, and psychomotor abilities.
The Satisfaction Level of Students with Disabilities with Library and Information Services
Authors: Smadi Osama Youssef
Published: March 2022

The study aimed to examine the level of satisfaction of students with disabilities with library and information services in Saudi universities. The descriptive survey approach was used. The study sample consisted of 35 students with disabilities enrolled in Imam Muhammad bin Saud Islamic University in the Kingdom of Saudi Arabia. A questionnaire was used to collect the data of the study. The results showed a number of information services and special environmental facilities available within the university central library, the frequencies, and percentages of their use by students with disabilities. They were ordered according to the students’ responses: book borrowing service, book return service, audiobooks, large print, and Braille book services. Also, it was revealed that the degree of satisfaction of students with disabilities with the library services provided to them was high. In addition, the physical environmental facilities of the library from the point of view of students with disabilities were the availability of a personal and designated place to study such as computer spaces and chairs suitable for students’ needs. The signs (directions) related to disability in the library and their compatibility with the needs of students with disabilities and the availability of tools and technologies to meet their needs in the library without the help of others were rated poor.
Reality of Using Modern Teaching Methods in Teaching English Language among Teachers
Authors: Al-Ghasab Ghazil Bader
Published: March 2022

The study aimed to reveal the reality of using modern teaching methods in teaching the English language by teachers and the differences according to the variables of gender, years of experience, and academic qualification. In this descriptive study, the study sample consisted of (239) male and female teachers selected from Mubarak Al-Kabeer region in the State of Kuwait. A questionnaire was used for data collection. The results showed that the reality of using modern teaching methods in teaching the English language among teachers came moderately. The direct, communicative, and audio-linguistic methods obtained the highest means in their use by teachers. It was also showed that there were statistically significant differences in the reality of using modern teaching methods in teaching the English language among teachers due to the variables of years of experience and in favor of the category of more than 10 years and academic qualification in favor of the postgraduate category. In addition, there were no statistically significant differences due to the gender variable. The study recommended the necessity of training and qualifying teachers on how to use modern teaching methods in teaching the English language in Kuwait.
Exploring the Spatial Pattern of Damage Caused by Typhoon Meranti on the Urban Green Space on Xiamen Island
Authors: Luo Huifen , Wu Junlin
Published: March 2022

Typhoons are the main cause of disturbances in the natural environment of coastal cities. Typhoons often damage the urban green space (UGS) of coastal cities, and the spatial pattern of such damages provides important information for disaster recovery. For acquiring such information, remote sensing technology offers a fast and effective means. This study investigated the spatial pattern of typhoon damage to UGS using Sentinel-2 data. To this end, the damage caused by Typhoon Meranti to the UGS of Xiamen Island (including Gulangyu Island) in 2016 was taken as a case study. The results showed that the overall area without vegetation coverage increased by 1159.7 ha. Areas with high vegetation coverage experienced less damage than areas with low vegetation coverage. A coldspot map of damage clusters was generated, and the map showed that severely damaged green areas were distributed in a striped pattern, indicating serious damage to road greening. In terms of direction, east-west roads experienced a higher degree of damage than north-south roads. The determined spatial pattern of the damage caused by Typhoon Meranti on the UGS of Xiamen Island provides a basis for the post-disaster restoration of the landscape of Xiamen Island.
Rapid Extraction of Yam Peel Total Flavonoids in A Cholinium-Based Magnetic Ionic Liquid Aqueous Biphasic System
Authors: Wang Y. , Wang F.W. , Jia M.F. , Huang L.N. , He Y.Q. , Dong S.Q.
Published: March 2022

In this study, for the first time, a magnetic ionic liquid-based aqueous biphasic system (MIL-ABS) was developed to extract total flavonoids from crude extracts of yam (Dioscorea alata L.) peel. The effect of various conditions on the separation behavior was systematically examined and optimized. A relatively high extraction efficiency (96.4%) and partition coefficient (K = 33.2) for total flavonoids could be achieved. MI-ABS not only has the advantage of being able to extract quickly in the absence of an organic solvent, but it also responds to a simple external magnetic field. This work has the potential to be a useful reference for practical enrichment or separation of active ingredients.
Einleitung zur thematischen Kollektion „Interaktionen im Fachunterricht lernförderlich gestalten“
Authors: Heller Vivien , Morek Miriam
Published: March 2022

Der Beitrag führt in die thematische Kollektion Interaktionen im Fachunterricht lernförderlich gestalten ein. Ausgehend von einer knappen Skizze der bisherigen Forschung zu Unterrichtsgesprächen über verschiedene Disziplinen hinweg werden die fachdidaktische Profilierung, die Berücksichtigung der Interaktivität unterrichtlicher Gesprächsverläufe und die Adaptivität lehrerseitigen Agierens als zentrale Desiderate identifiziert. Es wird aufgezeigt, welchen Beitrag die drei Artikel der Kollektion hierzu jeweils liefern. Zudem stellt der Beitrag heraus, inwiefern die Erfassung einer fachlich gehaltvollen und lernersensitiven Gestaltung von Unterrichtsgesprächen eine Kombination quantifizierender und sequenzanalytischer Verfahren erfordert.
A Study On Emotional Intelligence and Employee Performance in Public Sector Banks in Kerala
Authors: Babitha K.C , Murugesan G
Published: March 2022

ith the emergent development of globalization of the business world, organizations must adopt various sorts of strategies and additional procedures in comprehensive and pioneering way in order to achieve well-organized and effective work. Employees are the back bone of any organization and to make them work effectively, many strategies are being followed. Though, employees’ performance and effectiveness in the workplace depends on a number of factors such as financial support, educational background, job position and attitude etc. But, now leaders have also started giving consideration to Emotional Intelligence (EI) as one of the key element in organization’s success. EI is one of must-have skills and capabilities which are required by leaders and followers at workplace to encounter the environment changes and do as possible as they could to gain the organization commitments that could lead to organization’s success. Previous research exhibited that EI is also one of the important factor in organizational
commitment and there is a strong relationship between emotional intelligence and job satisfaction and Employee performance with leads to organizational commitment. Hence, the higher employees’ EI scores, higher will be employee performance and his commitment towards organization. Employees with high developed Emotional
Intelligence (EI) are proven to be more successful at workplace, because of the understanding of their emotions and why they behave in a particular situation in that way. In this study effect of emotional intelligence (EI) on employee performance in an organization has been investigated and the gap in the existing literature of Emotional intelligence has been identified. Assessing the reviews and analyses presented in this paper, it is expected that this review can be further referred in the new studies for the understanding of effect of emotional intelligence on employee performance.
La escuela de Frankfurt y la deconstrucción de la razón técnica en Horkheimer, Marcuse y Fromm
Authors: Jaimes Cienfuegos Javier
Published: March 2022

Se analiza el concepto de razón en las sociedades tecnológicas del siglo XX, a partir de tres de los más grandes representantes de la escuela de Frankfurt: Horkheimer, Fromm y Marcuse, los cuales realizaron una teoría crítica a partir de las bases políticas, económicas y filosóficas. La escuela de Frankfurt revaloriza el papel intelectual creado por las instancias capitalistas; advierte la imposibilidad de una teoría crítica a partir de la tecnociencia, ya que no se puede formar una conciencia subjetiva de una realidad opresiva objetiva.
Utilização de medicamentos alopáticos em concomitância com antineoplásicos frente às neoplasias de mama e próstata: uma revisão de literatura
Authors: Da Silva Iran Alves , Da Silva Lidiana Lúcia , Laurentino Carolayne da Silva , Alves Gabriela Quirino , Brito Jenyffer Kyara Chaves , Sultanun Rozana Firmino de Souza , Melo Jaíne Arruda , Coimbra Cynthia Gisele de Oliveira
Published: March 2022

As interações medicamentosas em pacientes com neoplasias de mama e próstata são um desafio na atualidade, tendo em vista que muitas vezes fazem uso de polimedicação. Assim, o presente estudo tem como objetivo analisar a utilização de medicamentos alopáticos em concomitância com antineoplásicos frente às neoplasias de mama e próstata. Realizou-se uma revisão de literatura integrativa, na base de dados PubMed utilizando-se os seguintes cruzamentos de busca "Drug Interactions” AND "Prostatic Neoplasms" e "Drug Interactions" AND "Breast Neoplasms”. A seleção se deu através da leitura das publicações, sendo incluídos artigos originais publicados nos últimos cinco anos, em qualquer idioma e disponíveis na íntegra. O uso de etexilato de dabigatrana, itraconazol, isavuconazol, midazolam, pantoprazol, prednisona, rifampicina e rosuvastatina demonstraram ausência ou baixo potencial de interação medicamentosa clinicamente relevante, quando administrados com os seguintes antineoplásicos darolutamida, docetaxel e metotrexato.
Parents' hopes for early childhood education during the covid-19 pandemic: a case study in gunungsari sub-district, west lombok regency, west nusa tenggara, Indonesia
Authors: Habibi Muazar
Published: March 2022

The purpose of this study was to find out the parents' hopes for early childhood education during the COVID-19 pandemic in Gunungsari Subdistrict, by using a descriptive qualitative method. The objects were all parents who have children in early childhood education in Gunungsari Sub-district. Data collection was carried out using questionnaires and documentation. Furthermore, the data was analyzed by using the Miles and Huberman flow model. The results showed that distance/online learning was able to improve the quality of learning, specifically in the field of self-proficiency during COVID-19, because it provides guidance and supervision during the learning process, even though distance/online learning cost more. Many parents hope school learning will resume as usual with the consideration that schools need to implement health protocols by limiting the number of children in class, providing hygiene and health facilities, and collaborating with the closest health center regarding health facilities.
Repositorio temático bajo el patrocinio de redes digitales para el aprendizaje en educación superior (CODAES)
Authors: González Pilar Cecilia Godina , Elías Ana Lourdes Aracely Borrego , Sánchez Eduardo García , Miramontes José Manuel Cervantes , Sánchez Miguel Ángel García , Ruiz Francisco Javier Martínez , García Luis Eduardo Bañuelos
Published: March 2022

La necesidad de flexibilizar la oferta educativa transitando a la modalidad semi-presencial así como la innovación en la creación de Objetos de Aprendizaje (OAs) son algunos de nuestros objetivos, presentamos la implementación de un repositorio de OAs, enfocado a fortalecer la comunicación oral y escrita, además de construir y delinear el pensamiento lógico y estructurado de los alumnos que cursan el primer semestre en ingeniería específicamente en la materia de programación.  Como es sabido, las nuevas tecnologías son permisibles en el sentido que es posible realizar las cosas en forma diferente a las efectuadas con tecnologías tradicionales y fuimos cuidadosos en crear escenarios de aprendizaje significativos cuidando que los contenidos fuesen claros para el alumno que utilizaría esos OAs.  No solo mostramos una vía para mejorar la práctica docente sino también mostramos el resultado conjunto de un equipo multidisciplinario y su contribución bajo el auspicio de Redes Digitales para el Aprendizaje en Educación Superior (CODAES).
A Matemática Financeira no Ensino Médio Brasileiro: perspectivas para formação de indivíduos críticos
Authors: Rezende Adriano Alves de , Silva-Salse Angela , Carrasco Eduardo
Published: March 2022

Segundo a Base Nacional Comum Curricular (BNCC) é imperativo formar cidadãos mais ativos, críticos, analíticos e que sejam capazes de modificar o ambiente no qual estão inseridos. O ensino da Matemática Financeira aos estudantes do Ensino Médio não foge a essa regra e é conhecimento fundamental a qualquer indivíduo. Assim, para entender a importância da Matemática Financeira buscou-se compreender como a Estratégia Nacional de Educação Financeira (ENEF) definida pelo Governo Federal, a BNCC e a Lei de Diretrizes e Bases da Educação Brasileira (LDB) interagem para promover o desenvolvimento destes cidadãos mais críticos e participativos na sociedade. Através de uma pesquisa qualitativa, baseada em revisão de literatura e documental buscou-se identificar os pontos convergentes e discrepantes entre estas três diretrizes legais e a formação de cidadão efetivamente críticos. Concluiu-se que a base legal para educação no Brasil proporciona às escolas esta opção. No Ensino Médio, particularmente, isso ocorre atualmente através da construção, por parte das escolas, do Projeto de Vida, além do exposto nas diretrizes da BNCC. As pesquisas que subsidiaram as conclusões demonstram que o uso de exemplos reais, práticos e aplicáveis a realidade rotineira dos alunos tem grande efeito para desenvolver o pensamento crítico na Matemática Financeira. Identificou-se também que uma exigência básica aos profissionais deste século é o desenvolvimento de sua criticidade em qualquer área do conhecimento, mas principalmente nas relacionadas e negócios e investimentos financeiros.
Demography of smallholder agricultural women and youth enterprises and their association with the cultivation of the tomato (Solanum Lycopersicum) vegetable crop
Authors: Nesamvuni Azwihangwisi E. , Tshikolomo Khathutshelo , Mpandeli Ndivhudzannyi S. , De Bruyn Melanie , Hlophe-Ginindza Samkelisiwe , Van Niekerk Johan
Published: March 2022

The study was conducted at the Madimbo corridor and upper Mutale valley smallholder irrigation schemes. The purpose of the study was to characterize smallholder agricultural women and youth entrepreneurs (SHAW-YE). A semi-structured household questionnaire together with facilitation was used to survey a sample, purposively focusing on Smallholder Agriculture Women and Youth Enterprises (SHAW-YE). The sample was comprised of 294 respondents with sub-samples of respondents selected through gender category, age category, and gender by age category. The study revealed that the SHAW-YE are characterized by small land areas under cultivation. There were some associations between age, education, and income of SHAW-YE with their capacity to produce tomatoes. Participation of women was 48.4% compared to 20% of men in the winter production of tomatoes. Production participation by SHAW-YE farmers for summer revealed that women were participating at 9.7% compared with 13.3% for men. The participation of SHAW-YE around the ages of 36-59-year was at 52.9% while that for ages >60-year was at 51.5%. The main source of variation may be the level of experience that the said age group of SHAW-YE may have in the production of tomatoes compared to 29.6% of 18–35-year participants. About 61.7% of SHAW-YE were at the level of Adult Basic Education & Training (ABET). About 45.8% of the SHAW-YE earned less than R5000.00 compared with 50.7% earning more than R5000.00. Market channels and access should be promoted for SHAW-YE to enable the throughput of tomatoes to not only informal but also fresh produce and retail markets.
Analysing Stokvels Development Through the Lens of Layered Conceptual Framework
Authors: Bophela Mduduzi Justice Kennedy
Published: March 2022

Despite the popularity of stokvels, there is dearth in studies to develop integrated models of stokvels. This study intends to provide a conceptual framework for developing an integrated framework by layering each component of the Maslow’s hierarchy of need and Hayes & Wheelwright business models. Simple random method was adopted on 395 stokvelgroup’s members who were administered with a questionnaire and the purposive sampling method on 6 MC members of eThekwini Municipality that participated in the interviews. The qualitative data was analysed using N-VIVO (version 11.0). The quantitative data was analysed using inferential and descriptive statistics. A new model layering Maslow’s theory with the Hayes & Wheelwright four-stage model was developed using a theory triangulation technique to validate the theories with the findings of the study.
Socioeconomic characteristic of street food vending enterprises in the Vhembe district, Limpopo province
Authors: Mahopo TC , Nesamvuni CN , Nesamvuni AE , De Bruyn Melanie , Van Niekerk J
Published: March 2022

The street food business is a crucial indirect driver of the economies of developing countries. It ought not to be ignored as most unemployed people turn to it as their primary means of earning a living to improve their lives. We studied the socioeconomic characteristics of the street food enterprises in the Vhembe district, South Africa. A cross-sectional survey of 511 street vendors (18-75 years old) was conducted. The socioeconomic characteristics of vendors in three towns of the Vhembe district were quantified. Data collected included age, gender, educational level, economic profile, factors influencing entry, foods sold, regulatory issues, and input suppliers. The results highlight the dominance (63.1%) of single middle-aged women (35-44 years old) with high school education and few young adults’ participation (4.1%) in the street food enterprise. About 14% of participants migrated from Zimbabwe to seek employment. Many of them (11.4%) reside in Musina. Lack of opportunities (65%) and financial freedom (90.8%) was the primary motivation for entry into the enterprise. Street food enterprises contributed about 82% of the average household income R6 042.66  made from the enterprise per month.  About 50%  of the street vendors are affiliated with a local organization. The most commonly cooked foods sold were pap (97.1%) served with chicken (88.8%) or beef (68.3%), with others serving with different vegetables (75.3%). The study recommends the prioritization of the establishment of local representative organizations in collaboration with the authorities to serve as gatekeepers for the sector, such as health checks, enforcing enterprise certification, promoting association for lobbying power and internally settling disputes.
Evaluation of Beriman's Terminal Retribution at Tomohon City
Authors: Munaiseche Stefano Yohanes , Dilapanga Abdul Rahman , Sendouw Recky Herold Elby , Mandagi Marthinus
Published: March 2022

Evaluation is a process of renewal activity, namely making efforts to make something more appropriate or suitable to the needs for the better or valuable. The terminal levy is a terminal levy as one of the business service fees collected by the regional government to any individual or private entity that utilizes terminal services that carry people or goods by public transportation. Understanding the terminal, before arriving at the terminal analysis then very needs to understand the function of a terminal. By understanding the terminal function, it is hoped that the understanding of the terminal will be more in-depth to facilitate the analysis. The function of the terminal is to provide means of entry and exit for driven objects, passengers, or vehicles goods to or leave the system. Terminal functions were like the description from terminal function automatically overall on all system models transportation. This study analyzes the retribution process at Beriman Terminal type B in Tomohon. The evaluation method was carried out using a qualitative method with the type of research, namely phenomenology. The informants in this study were 14 respondents as key informants. The research data were obtained from various data sources, namely primary and secondary data. Data was collected through interviews, documentation, and observation. Data reduction, presentation, and conclusion drawing are the data analysis techniques used. The data validation technique used is the source, technique, and time triangulation. The results of this study indicate that the management of the type B Terminal retribution in Tomohon city in September 2021 Tomohon is almost optimal. Based on several management indicators in this study, namely: 1) planning, not achieving the target of retribution and inadequate facilities and infrastructure, 2) organization, division, and work procedures are by their respective fields, 3) implementation, procedures carried out are by regulations and is carried out appropriately and adequately 4) supervision, supervision is carried out regularly and properly.