bluuebunny/crossref_metadata_2025 huggingface dataset:
Statistically strong label-free quantitative identification of native fluorophores in a biological sample
Authors: Mahbub Saabah B. , Plöschner Martin , Gosnell Martin E. , Anwer Ayad G. , Goldys Ewa M.
Published: November 2017

Bioimaging using endogenous cell fluorescence, without any external biomarkers makes it possible to explore cells and tissues in their original native state, also in vivo. In order to be informative, this label-free method requires careful multispectral or hyperspectral recording of autofluorescence images followed by unsupervised extraction (unmixing) of biochemical signatures. The unmixing is difficult due to the scarcity of biochemically pure regions in cells and also because autofluorescence is weak compared with signals from labelled cells, typically leading to low signal to noise ratio. Here, we solve the problem of unsupervised hyperspectral unmixing of cellular autofluorescence by introducing the Robust Dependent Component Analysis (RoDECA). This approach provides sophisticated and statistically robust quantitative biochemical analysis of cellular autofluorescence images. We validate our method on artificial images, where the addition of varying known level of noise has allowed us to quantify the accuracy of our RoDECA analysis in a way that can be applied to real biological datasets. The same unsupervised statistical minimisation is then applied to imaging of mouse retinal photoreceptor cells where we establish the identity of key endogenous fluorophores (free NADH, FAD and lipofuscin) and derive the corresponding molecular abundance maps. The pre-processing methodology of image datasets is also presented, which is essential for the spectral unmixing analysis, but mostly overlooked in the previous studies.
Ultrahigh field MR imaging of a subconjunctival anti-glaucoma drug delivery system in a rabbit model
Authors: Kopp Franziska , Eickner Thomas , Polei Stefan , Falke Karen , Witt Martin , Grabow Niels , Stachs Oliver , Guthoff Rudolf F. , Lindner Tobias
Published: November 2017

Local drug delivery systems (DDS) have become a favourable approach for the treatment of numerous diseases. Biomedical imaging techniques such as ultrahigh field magnetic resonance imaging (UHF-MRI) offer unique insight into DDS biodegradation in vivo. We describe the establishment of a 7 Tesla MRI routine for longitudinal in vivo examinations of a subconjunctival DDS for the treatment of glaucoma in a rabbit model. In initial in vitro examinations the T2-relaxation times of the polymeric DDS components were assessed. Imaging of enzymatically degraded depot samples in vitro did not reveal changes in sample morphology or T2-relaxation time. Ex vivo investigations with an enucleated porcine eye showed good correlation of anatomical MRI and histological data. In longitudinal in vivo studies in rabbits, we repeatedly scanned the depot in the same animal over the course of 5 months with an in-plane resolution of 130 µm at scan times of less than 30 minutes. The degradation was quantified using volumetric analysis showing a volume reduction of 82% between 3 and 21 weeks after depot implantation. We have thereby demonstrated the feasibility of our UHF-MRI protocol as a non-invasive imaging routine for qualitative and quantitative, longitudinal evaluation of biodegradable subconjunctival DDS.
NMR Metabolomics for Stem Cell type discrimination
Authors: Castiglione Franca , Ferro Monica , Mavroudakis Evangelos , Pellitteri Rosalia , Bossolasco Patrizia , Zaccheo Damiano , Morbidelli Massimo , Silani Vincenzo , Mele Andrea , Moscatelli Davide , Cova Lidia
Published: November 2017

Cell metabolism is a key determinant factor for the pluripotency and fate commitment of Stem Cells (SCs) during development, ageing, pathological onset and progression. We derived and cultured selected subpopulations of rodent fetal, postnatal, adult Neural SCs (NSCs) and postnatal glial progenitors, Olfactory Ensheathing Cells (OECs), respectively from the subventricular zone (SVZ) and the olfactory bulb (OB). Cell lysates were analyzed by proton Nuclear Magnetic Resonance (1H-NMR) spectroscopy leading to metabolites identification and quantitation. Subsequent multivariate analysis of NMR data by Principal Component Analysis (PCA), and Partial Least Square Discriminant Analysis (PLS-DA) allowed data reduction and cluster analysis. This strategy ensures the definition of specific features in the metabolic content of phenotypically similar SCs sharing a common developmental origin. The metabolic fingerprints for selective metabolites or for the whole spectra demonstrated enhanced peculiarities among cell types. The key result of our work is a neat divergence between OECs and the remaining NSC cells. We also show that statistically significant differences for selective metabolites characterizes NSCs of different ages. Finally, the retrived metabolome in cell cultures correlates to the physiological SC features, thus allowing an integrated bioengineering approach for biologic fingerprints able to dissect the (neural) SC molecular specificities.
Evidence for frozen melts in the mid-lithosphere detected from active-source seismic data
Authors: Ohira Akane , Kodaira Shuichi , Nakamura Yasuyuki , Fujie Gou , Arai Ryuta , Miura Seiichi
Published: November 2017

The interactions of the lithospheric plates that form the Earth’s outer shell provide much of the evidentiary basis for modern plate tectonic theory. Seismic discontinuities in the lithosphere arising from mantle convection and plate motion provide constraints on the physical and chemical properties of the mantle that contribute to the processes of formation and evolution of tectonic plates. Seismological studies during the past two decades have detected seismic discontinuities within the oceanic lithosphere in addition to that at the lithosphere–asthenosphere boundary (LAB). However, the depth, distribution, and physical properties of these discontinuities are not well constrained, which makes it difficult to use seismological data to examine their origin. Here we present new active-source seismic data acquired along a 1,130 km profile across an old Pacific plate (148–128 Ma) that show oceanic mid-lithosphere discontinuities (oceanic MLDs) distributed 37–59 km below the seafloor. The presence of the oceanic MLDs suggests that frozen melts that accumulated at past LABs have been preserved as low-velocity layers within the current mature lithosphere. These observations show that long-offset, high-frequency, active-source seismic data can be used to image mid-lithospheric structure, which is fundamental to understanding the formation and evolution of tectonic plates.
Mucoadhesive functionality of cell wall structures from fruits and grains: Electrostatic and polymer network interactions mediated by soluble dietary polysaccharides
Authors: Meldrum Oliver W. , Yakubov Gleb E. , Gartaula Ghanendra , McGuckin Michael A. , Gidley Michael J.
Published: November 2017

We demonstrate the enhancement of intestinal mucin (Muc2) binding to plant cell wall structures from fruit (parenchymal apple tissue) and grain (wheat endosperm) mediated by soluble dietary fibers embedded within cellulose networks. Mucin binding occurs through two distinct mechanisms; for pectin polysaccharides characteristic of fruits and vegetables, it is governed by molecular mucoadhesive interactions, while for neutral polysaccharides, arabinoxylan and β-glucan characteristic of cereal grains, the interaction stems from the properties of their polymer network. Based on microrheological and microscopic measurements, we show that neutral dietary fiber polysaccharides do not adhere to intestinal mucin, but are capable of disrupting the mucin network, which facilitates interpenetration of mucin molecules into the polysaccharide mesh. This effect becomes significant in the context of ‘whole foods’, where soluble fibers are incorporated within the gel-like matrix of cellulose-reinforced plant cell wall structures. The result of mucoadhesion assay and analysis of microscopy images points to the critical role of entanglements between mucin and polysaccharides as a lock-in mechanism preventing larger mucin from escaping out of plant cell wall structures. These results provide the first indication that non-pectin soluble dietary fiber may influence mucosal interactions, mucus barrier properties, and transmucosal transport of nutrients.
Effect of Long-term Incretin-Based Therapies on Ischemic Heart Diseases in Patients with Type 2 Diabetes Mellitus: A Network Meta-analysis
Authors: Chou Che-Yi , Chang Ying-Tzu , Yang Jia-Lian , Wang Jiun-Yi , Lee Tsui-Er , Wang Ruey-Yun , Hung Chin-Chuan
Published: November 2017

Patients with type 2 diabetes mellitus (T2DM) experience many cardiovascular complications. Several studies have demonstrated the cardioprotective effects of incretin-based therapies; however, there are few studies on the effects of long-term incretin-based therapies on cardiovascular events. Therefore, the present study conducted a systematic review and network meta-analysis to evaluate the effects of long-term incretin-based therapies on ischaemic diseases. We searched PubMed, CENTRAL, and Clinicaltrial.gov to retrieve randomised control trials reported until December 2016 and enrolled only RCTs with more than a 1-year follow-up. The network meta-analysis was performed using R Software with a GeMTC package. A total of 40 trials were included. Dipeptidyl peptidase 4 inhibitors and glucagon-like peptide-1 agonists were associated with a lower risk of myocardial infarction (MI) than were sulfonylureas (odds ratio [95% credible interval] 0.41 [0.24–0.71] and 0.48 [0.27–0.91], respectively). These results suggested that patients with T2DM receiving long-term incretin-based therapies have a lower risk of MI than do those receiving sulfonylurea-based therapy. These findings highlight the risks of cardiovascular events in patients who receive long-term incretin-based therapies, and may provide evidence for the selection of antidiabetic therapy in the future.
Null functions in three-dimensional imaging of alpha and beta particles
Authors: Ding Yijun , Caucci Luca , Barrett Harrison H.
Published: November 2017

Null functions of an imaging system are functions in the object space that give exactly zero data. Hence, they represent the intrinsic limitations of the imaging system. Null functions exist in all digital imaging systems, because these systems map continuous objects to discrete data. However, the emergence of detectors that measure continuous data, e.g. particle-processing (PP) detectors, has the potential to eliminate null functions. PP detectors process signals produced by each particle and estimate particle attributes, which include two position coordinates and three components of momentum, as continuous variables. We consider Charged-Particle Emission Tomography (CPET), which relies on data collected by a PP detector to reconstruct the 3D distribution of a radioisotope that emits alpha or beta particles, and show empirically that the null functions are significantly reduced for alpha particles if ≥3 attributes are measured or for beta particles with five attributes measured.
β-Eudesmol, an oxygenized sesquiterpene, stimulates appetite via TRPA1 and the autonomic nervous system
Authors: Ohara Kazuaki , Fukuda Takafumi , Ishida Yuko , Takahashi Chika , Ohya Rena , Katayama Mikio , Uchida Kunitoshi , Tominaga Makoto , Nagai Katsuya
Published: November 2017

Transient receptor potential ankyrin 1 (TRPA1) is a calcium-permeable non-selective cation channel, which is activated by various noxious or irritant substances in nature. TRPA1 activators have been generally recognized as noxious, however, foods and beverages containing TRPA1 activators are preferably consumed; the reasons for this discrepancy are not well understood. We demonstrate that TRPA1 is involved in the stimulatory appetite control mechanism. β-Eudesmol is an oxygenated sesquiterpene contained in medicinal or edible plants which activates TRPA1. Oral administration of β-eudesmol brought significant increments in food intake in rats and elevated plasma ghrelin levels. Gastric vagal nerve activity (GVNA) has been reported to affect feeding behavior. In vivo electrophysiological measurement of GVNA revealed that oral-ingestion of β-eudesmol significantly increased GVNA. This GVNA elevation was eliminated by TRPA1 inhibitor (HC-030031) treatment prior to β-eudesmol administration. The physiological effects of β-eudesmol, for example, incremental increase in food intake, ghrelin elevation and activation of GVNA, were significantly reduced in TRPA1 knockout rats. Our results indicated that β-eudesmol stimulates an increase in appetite through TRPA1, and suggests why TRPA1 activator containing foods and beverages are preferably consumed.
Early endosome motility mediates α-amylase production and cell differentiation in Aspergillus oryzae
Authors: Togo Yusuke , Higuchi Yujiro , Katakura Yoshinori , Takegawa Kaoru
Published: November 2017

Recent research in filamentous fungi has revealed that the motility of an endocytic organelle early endosome (EE) has a versatile role in many physiological functions. Here, to further examine the motility of EEs in the industrially important fungus Aspergillus oryzae, we visualized these organelles via the Rab5 homolog AoRab5 and identified AoHok1, a putative linker protein between an EE and a motor protein. The Aohok1 disruptant showed retarded mycelial growth and no EE motility, in addition to an apical accumulation of EEs and peroxisomes. We further demonstrated that the Aohok1 disruptant exhibited less sensitivity to osmotic and cell wall stresses. Analyses on the protein secretory pathway in ΔAohok1 cells showed that, although distribution of the endoplasmic reticulum and Golgi was not affected, formation of the apical secretory vesicle cluster Spitzenkörper was impaired, probably resulting in the observed reduction of the A. oryzae major secretory protein α-amylase. Moreover, we revealed that the transcript level of α-amylase-encoding gene amyB was significantly reduced in the Aohok1 disruptant. Furthermore, we observed perturbed conidial and sclerotial formations, indicating a defect in cell differentiation, in the Aohok1 disruptant. Collectively, our results suggest that EE motility is crucial for α-amylase production and cell differentiation in A. oryzae.
Morphological differentiation of Brachionus calyciflorus caused by predation and coal ash pollution
Authors: Xue Ying-Hao , Yang Xiao-Xue , Zhang Gen , Xi Yi-Long
Published: November 2017

Different rotifer stains exhibited remarkably morphological differences which could not be eliminated under laboratory conditions. In the present study, we hypothesized that predation pressure and pollution might be two forces driving morphological differentiation of rotifer. To test this hypothesis, rotifers (Brachionus calyciflorus) belonging to two sibling species were collected from three special lakes (with coal ash pollution, high predation pressure or neither) and cultured for more than three months to investigate their potential differentiation in morphology. Twelve morphological parameters were measured and compared among three lakes at four food density (Scenedesmus obliquus). The results showed that most of the tested morphological parameters changed in response to food level and differed among three habitats. Rotifers from the habitat with high predation pressure evolved stable long posterior lateral spine and relatively small body size. Rotifers collected from the polluted habitat was of smaller body size, compared with those from ordinary habitat. Bigger eggs were laid by rotifers from polluted area or lake with high predation pressure, enabling newborns more resistant to pollution or predation, and thus ensuring the survival rate of newborns. Finally, we concluded that both predation and pollution could affect the morphological differentiation and evolution of rotifers.
Primary aldosteronism patients show skin alterations and abnormal activation of glucocorticoid receptor in keratinocytes
Authors: Boix Julia , Bigas Judit , Sevilla Lisa M. , Iacobone Maurizio , Citton Marilisa , Torresan Francesca , Caroccia Brasilina , Rossi Gian Paolo , Pérez Paloma
Published: November 2017

Primary aldosteronism (PA) is a disease characterized by high aldosterone levels caused by benign adrenal tumors being the most frequent cause of secondary hypertension. Aldosterone plays vital physiological roles through the mineralocorticoid receptor (MR) but in certain cell types, it can also activate the glucocorticoid (GC) receptor (GR). Both MR and GR are structurally and functionally related and belong to the same family of ligand-dependent transcription factors that recognize identical GC regulatory elements (GREs) on their target genes. GCs play key roles in skin pathophysiology acting through both GR and MR; however, the effects of aldosterone and the potential association of PA and skin disease were not previously addressed. Skin samples from PA revealed histopathological alterations relative to control subjects, featuring epidermal hyperplasia, impaired differentiation, and increased dermal infiltrates, correlating with increased NF-κB signaling and up-regulation of TNF-A and IL-6 cytokines. PA skin samples also showed significantly higher expression of MR, GR, and HSD11B2. In cultured keratinocytes, aldosterone treatment increased GRE transcriptional activity which was significantly inhibited by co-treatment with GR- and MR-antagonists. This study demonstrates that high levels of aldosterone in PA patients correlate with skin anomalies and inflammatory features associated with abnormal GR/MR activation in epidermal keratinocytes.
Monolithic capillary columns consisting of poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) and their diol derivatives with incorporated hydroxyl functionalized multiwalled carbon nanotubes for reversed-phase capillary electrochromatography
Authors: Ganewatta Nisansala , El Rassi Ziad
Published: November 2017

Schemes for the preparation of the poly(GMA-co-EDMA) monolith and its diol monolith derivative with physically and covalently entrapped OH-MWCNTs.
A chemiluminescence method for the determination of verapamil hydrochloride in pharmaceutical and environmental samples based on an Fe3O4 nanoparticles enhanced NaHCO3–H2O2 system
Authors: Iranifam Mortaza , Hendekhale Nasim Rahmati
Published: November 2017

In this work, an Fe3O4 nanoparticles (NPs)-enhanced chemiluminescence (CL) method was developed for the determination of verapamil hydrochloride (VRP).
Bread-derived carbon foam as an adsorbent for solid-phase microextraction of polybrominated diphenyl ethers
Authors: Yu Hao , Zhao Yanfang , Yang Lingxiao , Chen Xiangfeng
Published: November 2017

In this work, bread-derived carbon foam (CF) was synthesized and used as a sorbent for solid-phase microextraction (SPME) of pollutants from environmental water samples.
Preparation and crystal structures of charge-transfer complexes of acyclic host molecules bearing pyrogallol derivatives with paraquat
Authors: Kawahata Masatoshi , Tominaga Masahide , Maekawa Yumi , Yamaguchi Kentaro
Published: November 2017

The complexation of paraquat with adamantane-based molecules possessing two or three pyrogallol derivatives as acyclic host molecules afforded charge-transfer cocrystals with a 2 : 1 host : guest complexation stoichiometry through noncovalent interactions.
Dynamics of poly(vinyl butyral) studied using dielectric spectroscopy and 1H NMR relaxometry
Authors: Pizzanelli Silvia , Prevosto Daniele , Labardi Massimiliano , Guazzini Tommaso , Bronco Simona , Forte Claudia , Calucci Lucia
Published: November 2017

Dielectric spectroscopy and NMR relaxometry unveiled the PVB segmental dynamics across the glass transition temperature.
Molecular mechanism of activation of Burkholderia cepacia lipase at aqueous–organic interfaces
Authors: de Oliveira Ivan Pires , Jara Gabriel Ernesto , Martínez Leandro
Published: November 2017

Structure and thermodynamics of lipase activation at aqueous–organic interfaces.
Probing plasma fluorinated graphene via spectromicroscopy
Authors: Struzzi C. , Scardamaglia M. , Reckinger N. , Sezen H. , Amati M. , Gregoratti L. , Colomer J.-F. , Ewels C. , Snyders R. , Bittencourt C.
Published: November 2017

The graphene fluorination using CF4 and SF6 plasma is investigated by combining spectroscopy and microscopy techniques.
Path-integral simulation of graphene monolayers under tensile stress
Authors: Herrero Carlos P. , Ramírez Rafael
Published: November 2017

Finite-temperature properties of graphene monolayers under tensile stress have been studied by path-integral molecular dynamics (PIMD) simulations.
Ring hydrogenation of aromatic compounds in aqueous suspensions of an Rh-loaded TiO2 photocatalyst without use of H2 gas
Authors: Nakanishi Kousuke , Yagi Ryosuke , Imamura Kazuya , Tanaka Atsuhiro , Hashimoto Keiji , Kominami Hiroshi
Published: November 2017

Aromatics with a carboxyl group were almost quantitatively hydrogenated to corresponding cyclohexanes over an Rh–TiO2 photocatalyst under H2-free conditions.
Efficient Pt–FeOx/TiO2@SBA-15 catalysts for selective hydrogenation of cinnamaldehyde to cinnamyl alcohol
Authors: Xue Yujie , Yao Ruihua , Li Junrui , Wang Guimei , Wu Peng , Li Xiaohong
Published: November 2017

Pt–FeOx/TiO2@SBA-15 serves as an efficient and recyclable catalyst for liquid-phase selective hydrogenation of cinnamaldehyde to cinnamyl alcohol under mild conditions.
Tuning the luminescence of two 3d–4f metal–organic frameworks for the fast response and highly selective detection of aniline
Authors: Li Ling , Zou Ji-Yong , You Sheng-Yong , Cui Hong-Min , Zeng Guo-Ping , Cui Jian-Zhong
Published: November 2017

Two 3D solvent-stable zinc(ii)–lanthanide(iii) MOFs were synthesized, serving as recyclable and selective turn-off luminescent sensors for aniline detection.
A spin crossover (SCO) active graphene-iron(ii) complex hybrid material
Authors: Senthil Kumar Kuppusamy , Šalitroš Ivan , Boubegtiten-Fezoua Zahia , Moldovan Simona , Hellwig Petra , Ruben Mario
Published: November 2017

A graphene-spin crossover (SCO) complex hybrid (Gr-SCO-A), prepared by non-covalently anchoring a pyrene tethered iron(ii)-SCO complex 1 with single/few layer graphene sheets, shows persistent thermal and light induced SCO.
2-Acyl-1,1,3,3-tetracyanopropenides (ATCN): structure characterization and luminescence properties of ammonia and alkali metal ATCN salts
Authors: Kayukov Ya. S. , Karpov S. V. , Grigor'ev A. A. , Nasakin O. E. , Tafeenko V. A. , Lyssenko K. A. , Shapovalov A. V. , Varaksina E. A.
Published: November 2017

Herein, ten crystal structure types and photoluminescence properties of 24 ammonia and alkali metal ATCN salts are described.
A multifunctional Ni(ii) coordination polymer: synthesis, crystal structure and applications as a luminescent sensor, electrochemical probe, and photocatalyst
Authors: Cui Jing-Wang , Hou Suo-Xia , Li Yue-Hua , Cui Guang-Hua
Published: November 2017

A new Ni(ii) complex containing 2,5-dichloroterephthalate and rigid bis(imidazole) ligands, which manifests multifunctional properties, has been synthesized and characterized.
Redox non-innocent bis(2,6-diimine-pyridine) ligand–iron complexes as anolytes for flow battery applications
Authors: Duarte Gabriel M. , Braun Jason D. , Giesbrecht Patrick K. , Herbert David E.
Published: November 2017

Reduce, reuse, recycle: Coordination complexes of ‘non-innocent’ diimine-pyridine ligands (DIP) are shown to be stable, multi-electron anolytes for redox-flow batteries.
Hierarchical MoS2nanosheets on flexible carbon felt as an efficient flow-through electrode for dechlorination
Authors: Huang Li-Zhi , Pedersen Steen Uttrup , Bjerglund Emil Tveden , Lamagni Paolo , Glasius Marianne , Hansen Hans Christian Bruun , Daasbjerg Kim
Published: November 2017

MoS2nanosheets were grown directly on carbon felt, which is used as flow-through electrode for reductive dechlorination.
Capsaicin inhibits the metastasis of human papillary thyroid carcinoma BCPAP cells through the modulation of the TRPV1 channel
Authors: Xu Shichen , Zhang Li , Cheng Xian , Yu Huixin , Bao Jiandong , Lu Rongrong
Published: November 2017

Capsaicin inhibits metastasis of human papillary thyroid carcinoma BCPAP cells through modulation of the TRPV1 channel.
Pharmaco-genomic investigations of organo-iridium anticancer complexes reveal novel mechanism of action
Authors: Hearn Jessica M. , Hughes George M. , Romero-Canelón Isolda , Munro Alison F. , Rubio-Ruiz Belén , Liu Zhe , Carragher Neil O. , Sadler Peter J.
Published: November 2017

Transcriptomic, phenotypic and high throughput data reveal unique anticancer mechanisms shared by organometallic iridium and osmium complexes.
Square planar Ni(ii) complexes of acetoneN4-phenyl-thiosemicarbazone andin situgenerated benzoyl thiosemicarbazide ligands: synthesis, spectral and structural characterizations, thermal behaviour and electrochemical studies
Authors: Paswan Santosh , Bharty M. K. , Bharati Pooja , Sonkar Piyush Kumar , Ganesan Vellaichamy , Butcher R. J.
Published: November 2017

Two novel complexes [Ni(Hapt)2] (1) and [Ni(btsc)] (2) have been synthesized from Hapt and Hbtsc by the reaction of Ni(ii) salt.
Osteoinductive superparamagnetic Fe nanocrystal/calcium phosphate heterostructured microspheres
Authors: Park So Yeon , Madhurakkat Perikamana Sajeesh Kumar , Park Jong Ho , Kim Sung Wng , Shin Heungsoo , Park Sung Pyo , Jung Hyun Suk
Published: November 2017

Superparamagnetic Fe/FeCaP heterostructured particles exhibit good osteogenic differentiation and magnetic sensitivity in an MRI scan, highlighting their promising potential as alternatives to conventional theranostic agents.
Polyethylenimine-coated Fe3O4 nanoparticles effectively quench fluorescent DNA, which can be developed as a novel platform for protein detection
Authors: Ma Long , Sun Nana , Zhang Jinyan , Tu Chunhao , Cao Xiuqi , Duan Demin , Diao Aipo , Man Shuli
Published: November 2017

We report a novel assembly of polyethyleneimine (PEI)-coated Fe3O4 nanoparticles (NPs) with single-stranded DNA (ssDNA), and the fluorescence of the dye labeled in the DNA is remarkably quenched.
Taking advantage of Co(ii) induced enhanced VCD for the fast and sensitive determination of enantiomeric excess
Authors: Arrico Lorenzo , Angelici Gaetano , Di Bari Lorenzo
Published: November 2017

Large Co(ii)-induced VCD signals provide a method for determining the enantiomeric excess of α-amino acids. This strategy can be followed for building new VCD protocols.
Highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides
Authors: Hamel Jean-Denys , Hayashi Tatsuru , Cloutier Mélissa , Savoie Paul R. , Thibeault Olivier , Beaudoin Meggan , Paquin Jean-François
Published: November 2017

A highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides is presented.
Visible-light responsive hydrogen-bonded supramolecular polymers based on ortho-tetrafluorinated azobenzene
Authors: Zhan Tian-Guang , Lin Meng-Di , Wei Jie , Liu Li-Juan , Yun Meng-Yan , Wu Lin , Zheng Si-Tai , Yin Huan-Huan , Kong Li-Chun , Zhang Kang-Da
Published: November 2017

Visible-light responsive hydrogen-bonded supramolecular polymers have been fabricated, whose properties could be regulated through the visible-light-triggered photoisomerization of the ortho-tetrafluorinated azobenzene.
Core-shell structured NaMnF3: Yb, Er nanoparticles for bioimaging applications
Authors: Ye Shuai , Zhao Mengjie , Song Jun , Qu Junle
Published: November 2017

A modified thermal decomposition method to synthesize single or core/shell structured lanthanide-doped NaMnF3 nanoparticles is proposed.
Heterogeneous hybrid of propyl amino functionalized MCM-41 and 1H-1,2,4-triazole for high efficient intermediate temperature proton conductor
Authors: Wu Zhenzhen , Li Juan , Zhang Xian-Ming
Published: November 2017

In this study, we introduced 1H-1,2,4-triazole into the ordered nanochannels of propyl amino functioned MCM-41 and then investigated the hybrids' proton conducting performance.
Synthesis of uniform porous NiO nanotetrahedra and their excellent gas-sensing performance toward formaldehyde
Authors: Fu Qingjie , Ai Mingmei , Duan Yi , Lu Lingmei , Tian Xin , Sun Dandan , Xu Yanyan , Sun Yaqiu
Published: November 2017

Porous NiO nanotetrahedrons and elongated irregular nanoparticles were synthesized, exhibiting superior gas-sensing behavior toward formaldehyde with high gas sensitivity and stability.
Dual mode temperature sensing through luminescence lifetimes of F- and O-coordinated Cr3+sites in fluorosilicate glass-ceramics
Authors: Wang Changjian , Wadhwa Abhishek , Cui Shuo , Ma Ronghua , Qiao Xvsheng , Fan Xianping , Zhang Xianghua
Published: November 2017

The authors reported a type of dual mode PL lifetime-based temperature sensing solely by Cr3+-singly-doped glass-ceramic materials. In applications, dual mode thermometry is highly accurate due to its “self-calibration” merit.
Dynamics of recombination via conical intersection in a semiconductor nanocrystal
Authors: Peng Wei-Tao , Fales B. Scott , Shu Yinan , Levine Benjamin G.
Published: November 2017

The ultrafast dynamics of nonradiative recombination at dangling bond defects is elucidated by nanoscale multireference ab initio molecular dynamics simulations.
Scalable thioarylation of unprotected peptides and biomolecules under Ni/photoredox catalysis
Authors: Vara Brandon A. , Li Xingpin , Berritt Simon , Walters Christopher R. , Petersson E. James , Molander Gary A.
Published: November 2017

A mechanistically distinct, Ni/photoredox-catalyzed arylation of unprotected, native thiols (e.g., cysteine residues) is reported – a process initiated through a visible light-promoted, hydrogen atom transfer (HAT) event under ambient conditions.
Conservation of direct dynamics in sterically hindered SN2/E2 reactions
Authors: Carrascosa Eduardo , Meyer Jennifer , Michaelsen Tim , Stei Martin , Wester Roland
Published: November 2017

The effect of steric hindrance on the stereodynamics of nucleophilic substitution (SN2) and base-induced elimination (E2) has been studied using crossed-beam velocity map imaging.
A solar-charged photoelectrochemical wastewater fuel cell for efficient and sustainable hydrogen production
Authors: Zhou Zhaoyu , Wu Zhongyi , Xu Qunjie , Zhao Guohua
Published: November 2017

A solar-charged photoelectrochemical wastewater fuel cell was constructed for efficient and sustainable hydrogen production based on the promotion of pollutant oxidation.
Defect engineering of highly stable lanthanide metal–organic frameworks by particle modulation for coating catalysis
Authors: Chen Yifa , Zhang Shenghan , Chen Fan , Cao Sijia , Cai Ya , Li Siqing , Ma Hongwei , Ma Xiaojie , Li Pengfei , Huang Xianqiang , Wang Bo
Published: November 2017

A powerful strategy to design the structure, control the particle sizes and fabricate catalytic devices is developed for lanthanide MOFs.
Light metal borohydrides/amides combined hydrogen storage systems: composition, structure and properties
Authors: Qiu Shujun , Chu Hailiang , Zou Yongjin , Xiang Cuili , Xu Fen , Sun Lixian
Published: November 2017

Studies on light metal borohydrides/amides combined systems are reviewed to provide inspiration for the further development of high-performance hydrogen-storage materials.
A self-powered broadband photodetector based on an n-Si(111)/p-NiO heterojunction with high photosensitivity and enhanced external quantum efficiency
Authors: Zhang Yongfang , Ji Tao , Zhang Wenlong , Guan Guoqiang , Ren Qilong , Xu Kaibing , Huang Xiaojuan , Zou Rujia , Hu Junqing
Published: November 2017

A broadband photodetector based on n-Si(111)/p-NiO heterojunctions not only shows excellent photosensitivity and EQE, but also exhibits outstanding self-powered properties.
Multicultural Neurogenics: A Call and Response to Embrace Global Issues in Neurogenics
Authors: Wallace Gloriajean L.
Published: November 2017

This epilogue outlines the call to address the clinical needs of adults from culturally and linguistically diverse backgrounds with neurogenic communication disorders, and the training needs of speech-language pathologists (SLPs) who provide those services. A response to those needs is provided in terms of advances that have been made over time, and limited areas that require future attention. Brief summaries are provided for articles in this issue, with reference to how each article contributes to advances in service delivery to culturally and linguistically diverse adults with neurogenic communication disorders around the world.
Gas and galaxies in filaments between clusters of galaxies
Authors: Bonjean V. , Aghanim N. , Salomé P. , Douspis M. , Beelen A.
Published: November 2017

We have performed a multi-wavelength analysis of two galaxy cluster systems selected with the thermal Sunyaev-Zel’dovich (tSZ) effect and composed of cluster pairs and an inter-cluster filament. We have focused on one pair of particular interest: A399-A401 at redshiftz~ 0.073 seperated by 3 Mpc. We have also performed the first analysis of one lower-significance newly associated pair: A21-PSZ2 G114.09-34.34 atz~ 0.094, separated by 4.2 Mpc. We have characterised the intra-cluster gas using the tSZ signal fromPlanckand, when possible, the galaxy optical and infrared (IR) properties based on two photometric redshift catalogues: 2MPZ and WISExSCOS. From the tSZ data, we measured the gas pressure in the clusters and in the inter-cluster filaments. In the case of A399-A401, the results are in perfect agreement with previous studies and, using the temperature measured from the X-rays, we further estimate the gas density in the filament and findn0= (4.3 ± 0.7) × 10-4cm-3. The optical and IR colour–colour and colour–magnitude analyses of the galaxies selected in the cluster system, together with their star formation rate, show no segregation between galaxy populations, both in the clusters and in the filament of A399-A401. Galaxies are all passive, early type, and red and dead. The gas and galaxy properties of this system suggest that the whole system formed at the same time and corresponds to a pre-merger, with a cosmic filament gas heated by the collapse. For the other cluster system, the tSZ analysis was performed and the pressure in the clusters and in the inter-cluster filament was constrained. However, the limited or nonexistent optical and IR data prevent us from concluding on the presence of an actual cosmic filament or from proposing a scenario.
THROES: a caTalogue of HeRschel Observations of Evolved Stars
Authors: Ramos-Medina J. , Sánchez Contreras C. , García-Lario P. , Rodrigo C. , da Silva Santos J. , Solano E.
Published: November 2017

This is the first of a series of papers presenting the THROES (A caTalogue of HeRschel Observations of Evolved Stars) project, intended to provide a comprehensive overview of the spectroscopic results obtained in the far-infrared (55−670 μm) with the Herschel space observatory on low-to-intermediate mass evolved stars in our Galaxy. Here we introduce the catalogue of interactively reprocessed Photoconductor Array Camera and Spectrometer (PACS) spectra covering the 55−200 μm range for 114 stars in this category for which PACS range spectroscopic data is available in the Herschel Science Archive (HSA). Our sample includes objects spanning a range of evolutionary stages, from the asymptotic giant branch to the planetary nebula phase, displaying a wide variety of chemical and physical properties. The THROES/PACS catalogue is accessible via a dedicated web-based interface and includes not only the science-ready Herschel spectroscopic data for each source, but also complementary photometric and spectroscopic data from other infrared observatories, namely IRAS, ISO, or AKARI, at overlapping wavelengths. Our goal is to create a legacy-value Herschel dataset that can be used by the scientific community in the future to deepen our knowledge and understanding of these latest stages of the evolution of low-to-intermediate mass stars.
Investigating the Enantiodetermining Step of a Chiral Lewis Base Catalyzed Bromocycloetherification of Privileged Alkenes
Authors: Denmark Scott , Böse Dietrich
Published: November 2017

The development of catalytic, enantioselective halofunctionalizations of unactivated alkenes has made significant progress in recent years. However, the identification of generally applicable catalysts for wide range of substrates has yet to be realized. A detailed understanding of the reaction mechanism is essential to guide the formulation of a truly general catalyst. Herein, we present our investigations on the enantiodetermining step of a Lewis base catalyzed bromocycloetherification that provides important insights and design criteria.
Metal-Free Oxidative Dimerization of Dithiocarbamates: Direct Access to 3,5-Bis-mercapto-1,2,4-thiadiazoles
Authors: Halimehjani Azim , Nosood Yazdanbakhsh , Didaran Shaghayegh , Aryanasab Fezzeh
Published: November 2017

A facile and efficient protocol for the synthesis of 3,5-bis-mercapto-1,2,4-thiadiazoles by the oxidative dimerization of S-alkyl dithiocarbamates using periodic acid as an inexpensive and commercially available oxidant is reported. High to excellent yields and short reaction times are the main advantages of this procedure.
Medial Proximal Femoral Angle better than Neck-Shaft Angle? Influence of Rotation on the Anteroposterior Radiograph
Authors: Fürmetz Julian , Wolf Florian , Euler Ekkehard , Thaller Peter , Degen Nikolaus
Published: November 2017

Neck-shaft angle (NSA) and medial proximal femoral angle (MPFA) describe the geometry of the proximal femur, but they are influenced by rotation. The MPFA is closer to the right angle and therefore assumed to be less influenced. This hypothesis was tested with a mathematical approach to compare the effects of rotation and their clinical relevance on both angles. We developed a three-dimensional (3D) geometrical model representing projectional radiography of the femoral axes under rotation and derived a mathematical equation. For validation purposes, we experimentally simulated projectional radiography and compared the results to those of the equation (five different inclinations of the femoral neck (IFN) each in 13 different rotations). The validated equation was used to determine the influence of rotation (–60° to +60°) on normal valued NSA and MPFA. The mean absolute difference between calculated and experimentally measured values was 0.6° (standard deviation [SD] 0.5; 0.0–2.2). The mean calculated difference between true and projected NSA was 7.1° (SD 7.1; 0.0–22.0), and for the MPFA, it was –1.9° (SD 2.2; –7.4 to 0.0). Clinically relevant deviations (≥5°) occurred at ≥30° external or ≥ 40° internal rotation for the NSA, for the MPFA at 60° external rotation. Mathematical modeling of radiographic projection of the IFN is possible to a high level of accuracy. Our results indicate that the NSA is significantly more susceptible to deviations caused by rotation than the MPFA. Clinicians must be aware of rotational influences in radiographic projection and possibly should use the MPFA instead of the NSA. The rotational influence during X-ray imaging must be controlled accurately, and femoral torsion should be quantified in computed tomography/magnetic resonance imaging (CT/MRI) scans if possible. 3-D bone models reconstructed from digital image data can be a future option for measuring true angles. Level of evidence was basic research.
Westphal Variant of Huntington's Disease
Authors: Cabarcas-Castro L. , Ramón-Gómez J. , Zarante-Bahamón A. , Bernal-Pacheco O. , Espinosa-García E. , Cote-Orozco J.
Published: November 2017

A Westphal variant of Huntington's disease (HD) is an infrequent presentation of this inherited neurodegenerative disorder. Here, we describe a 14-year-old girl who developed symptoms at the age of 7, with molecular evidence of abnormally expanded Cytosine-Adenine-Guanine (CAG) repeats in exon 1 of the Huntingtin gene. We briefly review the classical features of this variant highlighting the importance of suspecting HD in a child with parkinsonism and a family history of movement disorder or dementia.
Intracerebral Hematoma Following Evacuation of Chronic Subdural Hematoma: A Case Report and Review of Literature
Authors: Bansal Sumit , Mahapatra Ashok
Published: November 2017

Intracerebral hematoma is an unusual complication following surgical evacuation of chronic subdural hematoma. We report a case of 61-year-old patient operated at our department for a right-sided chronic subdural hematoma (CSDH), who presented with mild headache and left hemiparesis (4/5, Medical Research Council [MRC] grade). Postoperatively, the patient developed a small hematoma in ipsilateral frontal lobe. Serial computed tomography (CT) of the head showed progressive increase in size of hematoma with development of motor dysphasia. Frontal hematoma was evacuated by craniotomy and the patient improved in motor dysphasia. We emphasize the rarity of this complication and discuss the pathogenesis as well as management of this condition.
Stellenwert der koronaren Hybridrevaskularisation
Authors: Holubec Tomas , Liebetrau Christoph , Hecker Florian , Arsalan Mani , Van Linden Arnaud , Doss Mirko , Hamm Christian , Walther Thomas
Published: November 2017

Unter der hybriden koronaren Revaskularisation (HCR) versteht man die kombinierte chirurgische und interventionelle Therapie der koronaren Herzkrankheit bei Patienten mit signifikanter koronarer Mehrgefäßerkrankung. Die HCR wurde als eine Alternative zur konventionellen koronaren Bypassoperation oder zur „multi-vessel“ perkutanen koronaren Intervention bei mehreren tausend Patienten bereits erfolgreich durchgeführt. In diesem Übersichtsartikel wird ein Überblick über die Definitionen, die Indikationen zur HCR, zu Patientenselektion und zeitlichem Ablauf der Prozeduren sowie über die chirurgische Technik und die aktuelle Evidenz gegeben.
Ohrmuschelplastik der Dysplasie Grad I
Authors: Schneider Gerlind
Published: November 2017

Die Korrektur der Ohrmuscheldysplasie Grad I gehört zu den häufigsten ästhetischen Eingriffen im HNO-Gebiet. In den allermeisten Fällen liegt
eine komplexe Pathologie von Anthelix, Cavum conchae und/oder Lobulus vor. Der Operateur muss deshalb nach einer genauen Analyse der
Pathologie aus den verschiedenen Korrekturmöglichkeiten nach dem „Baukastenprinzip“ die für das spezielle Problem geeignetsten
Operationstechniken auswählen können.
Funktionalität und nichtinvasive Bildgebung
Authors: Gastl Mareike , Manka Robert , Kelm Malte , Bönner Florian
Published: November 2017

Nichtinvasive Bildgebung spielt eine zentrale Rolle bei Diagnose, Risikostratifizierung und klinischem Management von Patienten mit stabiler koronarer Herzkrankheit (KHK). Die Entscheidung zu einer anatomischen oder funktionellen Bildgebung wird anhand der Patienteneignung, der Prätestwahrscheinlichkeit sowie der lokalen Methodenverfügbarkeit und Expertise getroffen. Aktuelle große Studien zeigen, dass die anatomische Bildgebung zwar die KHK diagnostiziert, aber im Vergleich zur funktionellen Bildgebung keinen signifikanten Mehrwert für die Vorhersage der Gesamtletalität hat. Neben der Funktion der koronaren Makrostrombahn können funktionale Bildgebungsmodalitäten auch die der Mikrostrombahn mit signifikant besserer Vorhersage der Gesamtletalität erfassen. Die Wertigkeit der Ischämietestung ist vor dem Hintergrund der älter werdenden Patienten mit untypischen Symptomen und damit schwieriger Berechnung der Prätestwahrscheinlichkeit als besonders hoch einzustufen. Aktuelle technische Entwicklungen aller Modalitäten erweitern in unterschiedlicher Geschwindigkeit deren Präzision und diagnostische Genauigkeit. Durch eine Vielzahl an randomisierten, kontrollierten Studien wird die klinische Bedeutung der einzelnen Bildgebungsmodalitäten in Bezug auf Kosten, Entscheidungspfade und Letalität der Patienten kontrovers diskutiert.
Idiopathische subglottische Stenose: Rezidivwahrscheinlichkeit unverändert
Authors: Sittel Christian
Published: November 2017

Aarnæs MT et al. Idiopathic subglottic stenosis: an epidemiological single-center study. Eur Arch Otorhinolaryngol 2017; 274: 2225–2228

Wissenschaftler der HNO-Klinik der Universität Oslo untersuchten Inzidenz, Management und Behandlungsergebnisse der idiopathischen
subglottischen Stenose.
IVH in VLBW Preterm Babies – Therapy with Recombinant Activated F VII?
Authors: Knüpfer Matthias , Ritter Jenny , Pulzer Ferdinand , Gebauer Corinna , Wolf Nadine , Bläser Anett , Dreyhaupt Jens , Thome Ulrich
Published: November 2017

Backround Intraventricular hemorrhage (IVH) remains a dangerous and frequent complication in very low birth weight (VLBW) infants. Activated factor VII (aFVII) activates the coagulation cascade and is a potential tool for stopping active bleeding, including limiting the extent of an IVH. This retrospective treatment observation compared data for infants with IVH progression treated with fresh frozen plasma (FFP) alone or with a combination of FFP and aFVII.

Methods/Intervention All infants were subject to cranial ultrasonography at least twice daily. When an IVH was detected, treatment with FFP (5–20 ml/kg every 4–6 h) was commenced and the parents were informed. If the parents endorsed aFVII treatment and the IVH showed progress, aFVII (30–50 µg/kg body weight 4–6 times within 16–24 h) was given. Otherwise, infants were treated with FFP only. We compared the course of IVH between the aFVII+FFP treated infants and a control group (FFP only).

Results 35 patients throughout were included in the analysis (17 control and 18 aFVII group). Demographic data was not different between groups. The progress of IVH was significantly less in the aFVII group (p<0.01). During the hospital stay, 2 of the infants in the aFVII group died compared to 4 in the control group. A posthemorrhagic hydrocephalus developed in 3 aFVII and 6 control infants. All other outcome parameters and follow-up-results 2 years after treatment did not differ significantly.

Conclusion These data show that in the case of a progressing IVH, aFVII may be a candidate for limiting its extent. A prospective randomized trial is warranted.
Optimized care in Patients with Rare Diseases: TSC at the Center for Rare Diseases (ZSEUKS) at Saarland University Medical Center, Germany
Authors: Ebrahimi-Fakhari Daniel , Poryo Martin , Graf Norbert , Zemlin Michael , Flotats-Bastardas Marina , Heine Gunnar , Ragoschke-Schumm Andreas , Meyer Sascha
Published: November 2017

Providing comprehensive medical care for patients with rare diseases is both challenging and rewarding. We will give a short summary of the most relevant medical issues pertinent to this subject, and will illustrate some of these issues by sharing our experience in the care of patients with TSC disease.
Sekundärprävention bei koronarer Herzkrankheit – Was gibt es Neues?
Authors: Niederseer David , Niebauer Josef
Published: November 2017

Die koronare Herzerkrankung (KHK) ist aus epidemiologischen, aber auch gesundheitsökonomischen Gesichtspunkten eine der wichtigsten Erkrankungen unserer Zeit. Aufgrund des Vorhandenseins von effektiven Präventionsstrategien ist deren Umsetzung von zentraler Bedeutung. Hierbei wird zwischen einer nicht medikamentösen Prävention und einer medikamentösen Prävention unterschieden. Zentrales Anliegen beider Präventionsansätze ist eine optimale Einstellung der kardiovaskulären Risikofaktoren. Unter den nicht medikamentösen Präventionsmaßnahmen werden Nikotinkarenz, körperliche Aktivität, Gewichtsnormalisierung, Ernährungsumstellung und psychosoziale Interventionen zusammengefasst. Die medikamentösen Präventionsmaßnahmen zielen auf die optimale Einstellung von arterieller Hypertonie, Diabetes, Dyslipidämie, Plättchenaggregationshemmung und Medikamentenadhärenz ab. Nur eine optimale Abstimmung der nicht medikamentösen und medikamentösen Präventionsansätze kann bei Risikopatienten das erste kardiovaskuläre Ereignis oder bei Patienten mit stattgehabtem kardiovaskulärem Ereignis weitere Ereignisse verhindern.