bluuebunny/crossref_metadata_2025 huggingface dataset:
Finding the research gap of the potential anti-inflammatory activity of cocoa
(Theobroma cacao L.) through systematic literature review
Authors: Muhammad D.R.A. , Tjong K.T. , Martien R. , Siswanti  , Nursiwi A.
Published: April 2024

The use of conventional drugs in treating inflammation has various side effects, and thus it
is necessary to have an alternative anti-inflammatory agent that is effective and safe.
Cocoa (Theobroma cacao L.) is one of the agricultural products with a high content of
polyphenols, especially flavan-3-ols potentially used as an anti-inflammatory agent. The
purpose of this research is to investigate the research gap of the potential antiinflammatory activity of cocoa based on the published literatures. The systematic method
of synthesizing the review follows the guidelines of the PRISMA Statement 2020 using
the PICOS literature search strategy. The results of this study showed that the positive
effect of cocoa on inflammation indicated by 44 out of 72 biomarkers (61.11%). Flavan-3-
ols can effectively reduce inflammation by reducing the activation of transcripts that
regulate pro-inflammatory cytokines (NF-kB), prostaglandins, and NO. The antiinflammatory effect was effectively found in different groups, i.e., subjects without health
issue (healthy subject), subjects with some health problems record and subjects with
obesity. Nevertheless, it was found in the previous researches that the manifest of cocoaderived products as well as the biomarkers for determining the anti-inflammatory effect of
cocoa still vary. Also, there is no study investigating the anti-inflammatory effect of cocoa
on different age group. Therefore, further researches are required in this area to complete
the puzzle of information regarding the potential anti-inflammatory activity of cocoa.
TRANSPARENCY IN HEALTH SERVICES AT MAJENE REGIONAL GENERAL HOSPITAL, WEST SULAWESI
Authors: Solong Aras , Mahsyar Abdul , Rahman Mariati , Alim Andi
Published: April 2024

The research objective was to determine the transparency of the implementation of health services and the driving factors for the transparency of the implementation of health services at the Regional General Hospital Majene, West Sulawesi. This research uses a qualitative approach, this type of research is classified as qualitative descriptive research. Data collection through observation made direct observations in the field about events related to the object of research, while interviews conducted interviews with informants to obtain information on implementation transparency issues and driving factors affecting health services, and documentation is research by collecting data in the form of documents such as decrees and regulations. regulations relating to the object of the problem. For analysis starting from data collection, data reduction, data presentation and conclusion. The results of the study show that the transparency of the implementation of health services is transparent because of several indicators, namely, the suitability of service standards, the information system has been published clearly, and the requirements and administration of services are carried out properly and by those set by the hospital. The driving factor that affects the transparency of the implementation of health services at the Majene Regional General Hospital, West Sulawesi, is the availability of Human Resources, namely employees who are tasked with wearing identification and carrying out their duties and responsibilities according to their respective fields, and facilities and infrastructure have been provided to satisfy health services to the community.
QUESTIONS OF KNOWLEDGE AND POWER: CONTESTATIONS WITH SPECIAL REFERENCE TO THE PERFORMANCE OF DOUDINIS OF THE BODOS OF ASSAM
Authors: Daimary Ivy , Goswami Madhurima
Published: April 2024

This research paper attempts to explore the notions of knowledge and power in the traditions of doudini (priestess) of the Bodo tribe of Assam, North-East India. The present paper tries to argue that although a doudini possesses traditional knowledge and supernatural power, she is deprived of the rights to equality and freedom. The doudini through her ritualistic dance performance plays the role of a mediator between the people and the Gods. The raw blood of the sacrificial animals is consumed by her in the Kherai festival, an important ritual of the Bathou religion. She is then charmed by the chants of the priest and falls into a trance and transforms into a spiritual being. The community addresses her as nasoni (dancer) and some as doudini(spirit), depending on the status attributed to her in the particular society. The doudini plays many parts which are presented in a series to the same audience. Though the ritual is performed both by female priest and male priest, their role differs as doudini has to accomplish more performances compared to male priest. The doudini does not have freedom to act on her own as she performs, based on the rules set by the system. The doudini does not enjoy freedom throughout the entire process of the ritual as she is bound to perform every act set by the system.The present study has made a critical analysis on the role of doudini, discriminated on the ground of gender and questions her status based on the social system.
READING SILAPPADIKARAM IN THE CONTEMPORARY TIMES: A STUDY OF ITS PERFORMATIVE ASPECTS
Authors: Burla Venkata Naresh , M. Ramakrishnan
Published: April 2024

Silappadikaram is a classic literary work of ancient Tamil society, believed to have been composed around the 5th century BCE by Ilango Adigal. It encompasses elements of Jainism, Buddhism, and other religious traditions then prevalent, and also it incorporates themes, myths, and theological principles from each of the belief systems. The epic offers a vivid portrayal of both virtuous and malevolent deeds, while exploring themes of joy and suffering. What sets Silappadikaram apart from other epics is that the text focuses on an ordinary couple, as opposed to kings and armies. The text painstakingly demonstrates the behavioural nuances of society, ranging from commoners to rulers. Love and separation, gaining and losing power, are recurring themes in Indian classical dramas by notable playwrights like Vishakadatta, Kalidas, Bhasa, and Bhavabhuti, etc. These plays were created with the intention of influencing society, specifically targeting individuals in positions of power and authority. However, post-colonial Indian theatre took a different approach, placing common individuals as protagonists in the plays. Works such as Aadhe Adhure, Ghashiram Kotwal, Hayavadana, and Sakharam Binder address prevalent societal issues, with the central character being an ordinary person. The main aspects of modern theatre and the plays mentioned here primarily explore the everyday activities of common individuals and how they are influenced by other members of society, economic factors, and politics. This paper studies the contemporary relevance of Silappadikaram in modern theatre by drawing a comparison with these modern Indian plays.
Modeling of the Spread of Malaria in the Bangka Belitung Islands Province Using the SEIR Method
Authors: Halim Nikken , Putri Marwah Hotimah Nada , Alviari Irfaliani , Luthfiyah Fadillah , Septiani Hera , Prayanti Baiq Desy Aniska
Published: April 2024

Malaria is an infectious disease caused by plasmodium through the bite of the Anopheles sp mosquito. female (Roach, 2012). Malaria disease which hit the Bangka Belitung Islands Province in 2005 experienced a spike, reaching 36,901 people out of 981,573 residents and claimed the lives of 12 local residents. In 2011, the Bangka Belitung Islands Province was declared an endemic area for malaria. This research aims to model and interpret the spread of malaria using the SEIR model and predict the spread of malaria using parameter estimates. The steps in analyzing the SEIR model on the spread of malaria are making assumptions, forming a SEIR model, determining the equilibrium point and analyzing the stability of the equilibrium point, determining the basic reproduction number, and carrying out a simulation of the SEIR model that has been obtained. The SEIR model is classified into 4 classes, namely Susceptible (susceptible individuals), Exposed (individuals who have symptoms), Infected (infected individuals), and Recovered (recovered individuals). The data used in this research is data on the number of Susceptible, Exposed, Infected and Recovered malaria cases in 2022 obtained from the Bangka Belitung Islands Provincial Health Service. The SEIR mathematical model is used to calculate the equilibrium point and basic reproduction number. Based on the SEIR model simulation results, it was found that the susceptible population decreased from the 0th month to the 48th month. As for the exposed population, there were 9,623 people in month 0, but in this condition the population decreased drastically per month. Furthermore, for the infected population there were 129 people in month 0, but in this condition the number of infected decreased drastically per month along with the decrease in the exposed population. For individuals who recovered, there was a decrease from the 0th month to the 48th month.
INTOKSIKASI MERKURI: FAKTOR RISIKO, PATOFISIOLOGI DAN DAMPAKNYA BAGI WANITA HAMIL DI DAERAH LINGKAR TAMBANG
Authors: Ekawanti Ardiana , Priyambodo Seto
Published: April 2024

Paparan merkuri wanita hamil berasal dari berbagai sumber diantaranya polusi pertambangan emas, dari konsumsi ikan dan peralatan di sekitar lingkungan tempat tinggal. Intoksikasi yang terjadi sebagai akibat paparan tersebut ditentukan oleh jenis merkuri, rute, dosis, lama paparan dan umur pejamu. Paparan merkuri pada wanita hamil tidak saja menyebabkan intoksikasi bagi dirinya akan tetapi juga mempengaruhi janin yang dikandungnya. Janin merupakan fase perkembangan yang sangat rentan terpapar merkuri dari semua jenis yang berasal dari ibunya. Berbagai akibat yang dapat ditimbulkan dari paparan tersebut pada janin diantaranya kelahiran mati, berat badan lahir rendah dan kelainan kongenital.
RESPON IMUN PADA OLAHRAGA
Authors: Widiastuti Ida Ayu Eka
Published: April 2024

Fungsi sistem imun secara fisiologik adalah pertahanan terhadap mikroba infeksi; bahkan zat asing yang tidak menular dan produk sel yang rusak yang dapat menimbulkan tanggapan kekebalan. Respon dari berolahraga, baik akut maupun kronik akan memberikan efek terhadap komponen-komponen dalam sistem imun. Respon imun yang terjadi tergantung pada intensitas dan durasi berolahraga. Olahraga dengan intensitas sedang akan menstimulasi berbagai parameter yang berhubungan dengan imunitas seluler sehingga dapat menurunkan risiko infeksi, sedangkan olahraga dengan intensitas tinggi akan mengakibatkan pengurangan parameter yang sama, yang akan meningkatkan risiko penyakit infeksi. Respon dari berolahraga atau melakukan aktivitas fisik secara teratur dapat berpengaruh terhadap sel-sel imun, seperti: neutrofil, antigen precenting cell (APC), natural killer cell (NK cell), dan limfosit maupun terhadap produksi sitokin
DETERMINAN KECUKUPAN VITAMIN D PADA NELAYAN
Authors: Irawati Deasy , Ekawanti Ardiana , Nurbaiti Lina
Published: April 2024

Prevalensi defisiensi vitamin D di negara maju dan negara berkembang berkisar antara 30%-75% dengan peningkatan risiko defisiensi pada wanita, lansia, obesitas dan individu dengan paparan sinar matahari yang rendah. Nelayan merupakan kelompok pekerja yang banyak mendapat paparan sinar matahari. Walaupun demikian, penelitian terdahulu melaporkan bahwa 4 dari 5 nelayan mengalami defisiensi vitamin D. Penelitian ini bertujuan untuk menilai kecukupan asupan vitamin D dan paparan sinar matahari pada nelayan. Penelitian potong lintang ini melibatkan kelompok nelayan di wilayah kerja beberapa puskesmas di Mataram dan Lombok Barat. Subyek terbagi menjadi dua kelompok yakni kelompok nelayan dan bukan nelayan. Variabel utama penelitian ini adalah asupan vitamin D dan paparan sinar ultra violet (UV). Sebanyak 1 dari 2 nelayan dan 3 dari 4 partisipan bukan nelayan mengalami kekurangan asupan vitamin D. Jumlah ikan yang dikonsumsi oleh kelompok nelayan dan bukan nelayan adalah 937 gram dan 652 gram perminggu. Jenis ikan terbanyak yang dikonsumsi adalah tongkol. Asupan ikan sebesar 937 gram perminggu setara dengan asupan vitamin D sebesar ~12 μg perhari dan kadar vitamin D kelompok nelayan diprediksi sebesar 23,6 nmol/L. Mayoritas subyek pada kedua kelompok tidak dapat mencapai radiasi UVB yang optimal. Kekurangan asupan vitamin D dan tidak optimalnya paparan sinar matahari didapatkan pada kelompok nelayan dan bukan nelayan.
PENGARUH PEMBERIAN VARIASI BARBITURATE (Sodium Phenobarbitone) DOSIS LETHAL TERHADAP PANJANG LARVA LALAT FAMILI Calliphoridae PADA MEDIA BANGKAI TIKUS Rattus norvegicus GALUR WISTAR
Authors: Wulandari Dwi Astuti , Syamsun Arfi , Triani Eva
Published: April 2024

Menentukan waktu kematian (post-mortem interval) merupakan hal yang sangat penting dalam penyelidikan forensik. Pertumbuhan blowflies merupakan indikator waktu kematian yang utama dan paling akurat dalam memperkirakan PMI. Pertumbuhan lalat dapat dipengaruhi oleh berbagai faktor termasuk iklim, geografis, dan obat-obatan yang terkandung pada jenazah. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian variasi barbiturat (sodium phenobarbitone) dosis lethal terhadap panjang larva lalat famili Calliphoridae dalam memprediksi PMI. Penelitian ini merupakan penelitian eksperimental dengan desain post-test only control group yang dianalisis dengan uji analisis multivariat regresi linier. Penelitian ini terdiri dari 1 kelompok kontrol (dislokasi leher) dan 3 kelompok perlakuan fenobarbital (750 mg/kgBB, 900 mg/kgBB dan 1050 mg/kgBB). Kelompok penelitian kemudian dimasukkan ke dalam kandang yang berisi lalat Chrysomya sp. Pengukuran panjang larva dilakukan setiap 12 jam dengan mengambil larva ukuran terbesar pada setiap tikus dalam kelompok penelitian. Hasil penelitian menunjukkan bahwa fenobarbital merupakan faktor yang paling berpengaruh terhadap panjang larva lalat Chrysomya sp. (p<0,05, R= -0,64) dibandingkan faktor suhu dan kelembapan. Hasil uji Mann Whitney (p< 0,05) menunjukkan terdapat perbedaan panjang larva lalat yang bermakna pada masing-masing kelompok perlakuan. Pemberian variasi barbiturat (sodium phenobarbitone) dosis lethal mempengaruhi pertumbuhan panjang larva lalat Chrysomya sp.
BEBERAPA KHASIAT BUAH TIN (FICUS CARICA) DARI ANTIKONVULSAN, ANTIALERGI, ANTIINFLAMASI, ANTIHIPERGLIKEMI, ANTIKANKER HINGGA TERAPI HATI
Authors: Makmun Armanto , Azizah Fadhilah Nur
Published: April 2024

Buah tin (Ficus carica) adalah sumber zat besi, kalsium, fosfor, dan serat. Buah tin telah digunakan di seluruh dunia untuk mengobati berbagai gangguan kesehatan. Ficus carica berasal dari Timur Tengah dan Asia Barat, tetapi menyebar ke banyak wilayah lain di dunia. Produk dari Ficus carica banyak digunakan sebagai sumber makanan dan obat-obatan untuk mengobati berbagai penyakit. Berdasarkan uraian yang disebutkan, maka peneliti tertarik untuk mengkaji lebih lanjut mengenai manfaat yang terkandung dalam buah tin. Penelitian ini menggunakan metode meta analisis kuantitatif. Sumber data penelitian ini berasal dari literatur yang diperoleh melalui internet berupa hasil penelitian dari jurnal internasional tahun 2016-2020 seperti Elsevier, Clinical Key, Pubmed, dan Research Internasional. Dari total 50 jurnal yang telah penulis review, kesimpulannya adalah manfaat kandungan dalam buah tin adalah dapat digunakan sebagai: buah tin sebagai antikanker, buah tin sebagai antikonvulsan, buah tin sebagai camilan sehat, buah tin sebagai antiinflamasi dan antitumor, buah tin sebagai alternatif terapi penyakit hati, buah tin sebagai antihiperglikemik, dan buah tin sebagai anti alergik. Maka dari itu, penulis berharap dengan adanya article review ini dapat menambah informasi masyarakat mengenai manfaat buah tin dan dapat mengambil manfaat buah tin untuk menjaga kesehatan tubuh Berdasarkan hasil penelitian ditemukan banyaknya manfaat buah tin untuk kesehatan tubuh yaitu antikonvulsan, antialergi, antiinflamasi, antihiperglikemi, antikanker dan sebagai hepatoprotektor.
MASKNE: AKNE AKIBAT MASKER
Authors: Hidajat Dedianto
Published: April 2024

Salah satu upaya pencegahan terhadap transmisi virus COVID-19 adalah dengan menggunakan masker secara kontinu. Namun demikian, penggunaan masker dalam jangka waktu tertentu menimbulkan berbagai efek samping dan yang paling sering, yaitu akne. Maskne merupakan varian akne yang timbul akibat penggunaan masker. Berbagai faktor yang diduga terkait dengan kejadian maskne antara lain jenis, lama penggunaan masker, riwayat akne sebelumnya, dan kebersihan pribadi. Namun tidak menutup kemungkinan faktor lain perlu diidentifikasi. Penanganan non farmakologis seperti penggunaan dan pengelolaan masker yang baik dan benar merupakan hal yang penting selain penanganan farmakologisnya. Belum banyak penelitian mengkaji efektivitas masker dan kaitannya dengan maskne ini.
PENCEGAHAN DAN PENGENDALIAN INFEKSI PADA JENAZAH PASIEN COVID-19
Authors: Harahap Ida Lestari
Published: April 2024

Data global dari World Health Organization (WHO) melaporkan penularan COVID-19 dari manusia ke manusia terjadi melalui droplet, kontak dan benda yang terkontaminasi. Kontak penularan tidak hanya terjadi pada pasien hidup namun juga dapat terjadi pada jenazah pasien terkonfirmasi COVID-19. Orang-orang yang bekerja atau yang melakukan kontak dengan jenazah memiliki potensi terpapar agen infeksi. Pasien yang meninggal dalam kondisi COVID-19 memerlukan protokol khusus untuk dalam penanganannya. Meski pasien sudah meninggal virusnya masih berbahaya dan dapat menular kepada orang-orang yang melakukan kontak dengan jenazah tersebut. Penularan dapat terjadi saat semua proses pengurusan jenazah mulai dari saat jenazah dimandikan, pemasangan kain kafan, melakukan sholat jenazah, proses autopsi jenazah, sampai pada penghantaran dan pemakaman jenazah. Sebagai upaya pencegahan penularan kepada petugas yang menangani jenazah tersebut, perlu menerapkan prosedur yang aman dan penggunaan alat pelindung diri yang sesuai.
KARAKTERISTIK PASIEN ATRIAL FIBRILASI PADA PASIEN RAWAT JALAN RUMAH SAKIT UMUM DAERAH PROVINSI NUSA TENGGARA BARAT PERIODE JANUARI 2015 HINGGA JANUARI 2016
Authors: Irmansyah Yos Akbar , Pintaningrum Yusra
Published: April 2024

Atrial fibrilasi (AF) merupakan disritmia yang paling sering ditemukan dan kini menjadi masalah kesehatan masyarakat yang telah mencapai proporsi epidemik di beberapa negara. AF memiliki nilai insidensi yang cukup stabil, yaitu sekitar 1-2%, dimana insidensi ini bertambah seiring dengan bertambahnya usia, dan diketahui lebih banyak terjadi pada populasi perempuan. Kurangnya data yang tersedia terutama dalam menjelaskan angka prevalensi dan insidensi AF terutama pada negara-negara berkembang seperti Indonesia pada umumnya, dan khususnya di wilayah kerja Rumah Sakit Umum Daerah Provinsi Nusa Tenggara Barat. Tujuan penelitian ini ialah untuk melihat gambaran karakteristik penyakit AF yang ada di Rumah Sakit Umum Provinsi Daerah Nusa Tenggara Barat selama 1 Januari 2015 hingga 31 Januari 2016. Penelitian ini merupakan penelitian observational deskriptif dengan desain cross sectional. Data yang digunakan merupakan data sekunder dan terdiri atas dua jenis data (registrasi elektronik dan rekam medik tertulis). Data yang dikumpulkan termasuk total kunjungan pasien rawat jalan poliklinik jantung, total kunjungan pasien AF, dan karakteristik pasien AF yang terdiri atas usia, jenis kelamin, dan kejadian stroke. Data tersebut kemudian disajikan dalam bentuk tabel dan grafik. Prevalensi AF selama 1 tahun sebesar 0,37%, dengan insidensi 46/100,000 pada laki-laki dan 64,4/100.000 pada perempuan. Dari 51 rekam pasien AF, didapatkan 62,7% pasien perempuan dan 37,3% pasien laki-laki. Berdasarkan hasil ekokardiografi sebanyak 33,3% disebabkan oleh tipe valvular dan 17,6% lainnya ialah non-valvular dengan rata-rata usia tiap kelompok 50,41 ± 13,20 dan 51,78 ± 14,35. Riwayat kejadian stroke ditemukan sebesar 25,4% pada pasien AF dan lebih tinggi pada pasien berjenis kelamin perempuan.
UJI AKTIVITAS ANTIPARAMPHISTOMIASIS INFUS BUNGA WIDURI (Colotropis gigantea) TERHADAP Paramphistomum spp. SECARA IN VITRO
Authors: Solehah Kurnia , Damiyati Siska Yunita , Pratama Iman Surya , Tresnani Galuh
Published: April 2024

Prevalensi paramphistomiasis di Provinsi Nusa Tenggara Barat tahun 2014 mencapai 20,7%. Tujuan penelitian untuk membandingkan aktivitas infus bunga Widuri berbagai konsentrasi terhadap Paramphistomum spp. secara in vitro terhadap Albendazol 10% b/v. Paramphistomum dewasa dikelompokkan ke dalam 5 kelompok: kontrol negatif (larutan NaCl 0,9% b/v), kontrol positif (Albendazol 10% b/v), dan infus bunga Widuri (5, 20 dan 40% b/v). Tiap kelompok diinkubasi pada suhu 37oC, kemudian diamati waktu kematian setiap 15 menit selama 5 jam. Persentase mortalitas ditentukan dan dianalisis secara statistik dengan parametrik dan non-parametrik menggunakan perangkat lunak SPSS v.16. Rerata waktu kematian untuk tiap kelompok berturut-turut 270; 23,33 ± 5.77; 16,67 ± 11.55; 103,33 ± 5.77; dan 146,67 ± 5.77 menit. Infus bunga Widuri 5% b/v efektif sebagai antiparamphistomiasis ditinjau dari rerata waktu mortalitas yang berbeda bermakna (p<0,05) lebih rendah dibandingkan Albendazol 10% b/v.
TANAMAN OBAT PADA RAMUAN B2P2TOOT DI PUSKESMAS PEJERUK AMPENAN KOTA MATARAM
Authors: Sari Kartika Permata , Aini Siti Rahmatul , Hanifa Nisa Isneni
Published: April 2024

Ramuan obat tradisional dari B2P2TOOT adalah ramuan paling banyak yang diresepkan oleh dokter dari 12 provinsi pada tahun 2014. Syarat Fasyankes dapat memberikan pelayanan obat tradisional khususnya ramuan B2P2TOOT adalah memiliki tenaga kesehatan yang telah mengikuti pelatihan saintifikasi jamu. B2P2TOOT terus melakukan evaluasi terhadap ramuan obat yang diberikan dengan memonitoring efek obat dari pelayanan Yankestrad yang menggunakan ramuan B2P2TOOT. Tujuan dari penelitian ini untuk mengetahui komposisi ramuan B2P2TOOT khususnya di Puskesmas Pejeruk Ampenan Kota Mataram yang memberikan pelayanan obat tradisional. Penelitian ini menggunakan metode kualitatif dengan metode pengambilan data secara cross sectional jenis purposive sampling. Terdapat sebanyak 11 ramuan B2P2TOOT di Poli jamu Puskesmas Pejeruk Ampenan. Ramuan B2P2TOOT tersebut dalam bentuk kapsul yang sudah diracik sesuai komposisi tanaman. Komposisi tanaman obat dari tiap-tiap ramuan berbeda, namun secara keseluruhan ramuan tersebut berasal dari tanaman obat yang ada di Indonesia. Spesies tanaman yang dominan digunakan pada 3 atau lebih ramuan B2P2TOOT adalah daun salam (Syzgium polyanthum (Wight Walp), bunga cengkeh (Syzygium aromaticum), dan temulawak (Curcuma xanthorriza Roxb). Berdasarkan hasil penelitian yang telah dilakukan, maka dapat diambil kesimpulan bahwa komposisi ramuan obat tradisional yang diresepkan di Puskesmas Pejeruk Ampenan Kota Mataram berasal dari tanaman obat Indonesia. Tanaman obat yang paling banyak digunakan dalam ramuan yaitu daun salam, bunga cengkeh dan temulawak yang digunakan pada terapi 3 penyakit atau lebih. Setiap tanaman obat memiliki kandungan metabolit sekunder yang mampu memberikan efek terapi, akan tetapi diperlukan kandungan dari tanaman lain untuk mendukung efek terapi yang diinginkan.
PENGARUH EKSPRESI RESEPTOR INSULIN PANKREAS TERHADAP EKSPRESI GLUT4 NEURON HIPOKAMPUS PADA TIKUS MODEL DIABETES
Authors: Sahly Aliza Raudatin , Hunaifi Ilsa , Lestari Rizka Vidya , Wardani Indah Sapta
Published: April 2024

Diabetes melitus (DM) merupakan penyakit degeneratif yang ditandai dengan kondisi hiperglikemia. Data Riset Kesehatan Dasar tahun 2018 menunjukan peningkatan prevalensi DM di Indonesia selama 5 tahun terakhir dengan 6,9% pada tahun 2013 menjadi 8,5% di tahun 2018. Ekspresi reseptor insulin pankreas dapat menjadi marker untuk menilai keberadaan sel β, produksi dan sekresi dari insulin. Insulin berperan dalam menyebabkan GLUT4 ditranslokasikan ke membran sel neuron hipokampus. Pada kondisi DM dapat terjadi perubahan ekspresi reseptor insulin pankreas yang disertai dengan perubahan ekspresi GLUT4 neuron hipokampus. Penelitian eksperimental ini menggunakan 16 ekor tikus putih (Rattus novergicus) yang dibagi secara acak menjadi 4 kelompok, yaitu 2 kelompok kontrol (A0 dan A1) dan 2 kelompok perlakuan (B0 dan B1). Kelompok perlakuan diinduksi diabetes dengan nikotinamid 110 mg/kgBB dan streptozotocin 70 mg/kgBB dosis tunggal secara intraperitoneal. Data penelitian diperoleh dari pemeriksaan imunohistokimia jaringan pankreas dan hipokampus. Rerata ekspresi reseptor insulin pankreas kelompok tikus diabetik lebih tinggi tetapi tidak signifikan pada pengamatan hari ke-14 dibandingkan hari ke-0 (p>0,05), sedangkan rerata ekspresi GLUT4 neuron hipokampus signifikan lebih tinggi pada pengamatan hari ke-14 dibandingkan hari ke-0 (p<0,05). Hasil uji korelasi tidak menunjukkan hasil yang signifikan pada pengamatan hari ke-0 maupun hari ke-14 untuk masing-masing kelompok (p>0,05). Tidak terdapat pengaruh yang signifikan dari ekspresi reseptor insulin pankreas terhadap ekspresi GLUT4 neuron hipokampus pada tikus model diabetes.
GAMBARAN KARAKTERISTIK, INTERNATIONAL PROSTATE SYMPTOM SCORE, DAN QUALITY OF LIFE PASIEN BENIGN PROSTATE HYPERPLASIA DI RSUD KOTA MATARAM
Authors: Samudera I Made Ari , Nandana Pandu Ishaq
Published: April 2024

Benign Prostate Hyperplasia (BPH) merupakan penyakit degeneratif yang menimbulkan ketidaknyamanan. Faktor resiko BPH, yaitu: usia, obesitas, dan diabetes melitus (DM). Penilaian keadaan pasien menggunakan International Prostate Symptom Score (IPSS) berisi tujuh pertanyaan dan satu pertanyaan Quality of Life (QoL). Penelitian ini bertujuan untuk mengetahui gambaran faktor resiko BPH, IPSS score, dan QoL score. Penelitian menggunakan rancangan dekstriptif-cross sectional. Sampel penelitian adalah pasien BPH di RSUD Kota Mataram sebanyak 43 orang. Instrumen penelitian menggunakan rekam medis, alat ukur tinggi dan berat badan, dan acuan nilai IPSS score dan QoL score pada PPK BPH IAUI. Penelitian ini menemukan pasien yang berusia 70-79 tahun sebanyak 44,1%, 60-69 tahun 37,2%, ≥80 tahun 11,6 %, dan 50-59 tahun 6,9%. Pasien dengan DM 18,6% dan non-DM 81,4%. Pasien dengan obesitas 27,9% dan non-obesitas 72,1%. IPSS score kategori sedang 44,1%, berat 39,5% dan ringan 16,2%. QoL score terbanyak dengan nilai 4 sebanyak 27,9% dan terendah QoL score 0 sebanyak 2,3%. Pasien BPH didominasi usia 70-79 tahun 44,1%, non-DM 81,4%, dan non- obesitas 72,1%. IPSS score didominasi kategori sedang 44,1% dan QoL score dengan nilai 4 sebanyak 27,9 %.
Análise do crescimento urbano da cidade de Conselheiro Lafaiete, a partir da década de 1990
Authors:   , Batista Gilsomar Sebastião , Rocha Cleusa Batista da , Santos Jonas Condé dos , Silva Leonardo Daniel Costa , Amorim Thalita Cristiane Barros
Published: April 2024

A cidade mineira de Conselheiro Lafaiete experimentou rápido crescimento nas últimas décadas do século XX, principalmente ancorada na expansão da atividade industrial nos municípios do seu entorno. Embora, o município da cidade em análise não disponha de tais atividades em larga escala em seus limites territoriais, os impactos das atividades microrregionais fizeram com que Conselheiro Lafaiete passasse ao nível de cidade média, experimentando desafios e problemas características desse nível hierárquico da rede urbana. O presente trabalho analise dados, causas e consequências desse crescimento, mostrando a transformação do espaço urbano e suas consequências na paisagem e na vida dos cidadãos.
Debates sobre educação no Brasil: olhares interdisciplinares vol. 5
Authors: Mateus Natasha Nickolly Alhadef Sampaio , Mateus Yuri Givago Alhadef Sampaio
Published: April 2024

A obra Debates sobre educação no Brasil: olhares interdisciplinares volume 5 teve por finalidade dar visibilidade para o debate em torno da educação brasileira sob diversos olhares, isto é, como cada área do conhecimento (Ciências Humanas, Ciências da Natureza, Linguagens, Códigos, Matemática e suas Tecnologias) vem sendo aplicada no âmbito escolar, desde a educação básica ao ensino superior. Buscou-se discutir os entraves que historicamente assolam a educação, bem como os novos problemas que desafiam os educadores/as e educandos/as no cotidiano escolar.
Samba e identidade: um guia didático sobre a Era Vargas
Authors: Silva Fabio Henrique Monteiro , Silva Thays Conceição de Jesus Barbosa
Published: April 2024

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A utilização da música como ferramenta para o desenvolvimento da espiritualidade
Authors: Sousa Maria Jucilene Silva Guida de , Mateus Natasha Nickolly Alhadef Sampaio
Published: April 2024

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Enem em Libras: percurso histórico, acessibilidade e garantia de direito linguístico
Authors: Ferreira João Batista Neves , Araújo Denise Lino Denise Lino de , Porto Shirley Barbosa das Neves
Published: April 2024

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Língua brasileira de sinais (Libras): aspectos, desafios e a busca por uma educação inclusiva em prol do processo de aprendizagem
Authors: Ferreira Emanoelly Carvalhal , Silva Aleandra Muniz Carvalhal de Queiroz , Silva Daniel da , Pinto Larissa Moreira , Silva Sinthia Moreira
Published: April 2024

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Projeto Refugiados: Entrelaçamentos possíveis entre as disciplinas de Língua Portuguesa, Língua Inglesa e Educação Física
Authors: Nunes Mariana Backes , Rodrigues Márcia Cristina Pires
Published: April 2024

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O trabalho com a produção textual escrita no livro didático de português: análise do volume 1 da coleção “Projeto Lumirá”
Authors: Silva Jorge Luís Lira da
Published: April 2024

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ESCRITAS DE QUEM OUSA ESPERANÇAR: PESQUISAS, VIVÊNCIAS E PRÁXIS - Volume II
Authors: Pinto Adriano Vieira , Castro Alaides Vieira de Sousa , Macedo Aline Sampaio , Silva Amanda Kelly Ferreira da , Vieira Ana Beatriz da Silva , Paula Ana Kátia Santos de , Santos Antónia Ana Lene Vieira dos , Oliveira Aparecida Kele Almeida , Ribeiro Ariane Nobre , Costa Cássia Eufrásia da Silva , Rodrigues Claudiana Soares Veras , Santos Cristiana de Paula , Farias Cristiane Jurdenia de , Matos Débora Stefani Pereira , Chaves Edmilson Rodrigues , Carvalho Francisca Sheila Pimenta de , Ferreira Francisco Hélio Damasceno , Lima Genizia Fernandes de , Damasceno Gerviz Fernandes de Lima , Franz Gustavo Bordignon , Dias Idalina Maria Sampaio da Silva Feitosa , Melo Jacqueline Machado de , Nogueira Luciana Íris Amaro , Andrade Marcilene Barbosa de , Elias Maria Cristina de Sousa , Araújo Maria Kleydyanya Mendes de , Teixeira Mirian Vieira , Martins Valda Maria Torres , Sabóia Valquíria Soares Mota , Santos Verônica Lopes dos , Vale Welliton Correia , Silva Witória Costa e , Oliveira Zilmar Alves De
Published: April 2024

Este livro é uma reflexão profunda sobre a educação, abordando suas principais questões, desafios e possibilidades. É um convite à reflexão e à transformação do sistema educacional, buscando caminhos que promovam a formação de cidadãos críticos, conscientes e comprometidos com a construção de uma sociedade mais justa e igualitária. Nestes tempos de incerteza, sabemos que a esperança pode parecer um sonho irracional, mas recusando-nos a ceder à escuridão. A cada passo que damos, rejeitamos a resignação e nos apegamos à fé na humanidade e na capacidade de transformação que cada um carrega consigo. Recusando-nos a aceitar a narrativa de que estamos condenados a um destino sombrio.
Ao longo das páginas deste livro, serão discutidos temas como a importância da educação inclusiva, que respeite a diversidade e valorize o potencial de cada indivíduo; a necessidade de uma educação que esteja em sintonia com as demandas do mundo do trabalho, preparando os estudantes para as profissões do futuro e construindo sua identidade pessoal; e a urgência de uma educação que promova a sustentabilidade, preocupando-se com o meio ambiente e estimulando a consciência ecológica.
Not a Monolith: Understanding of Racism and Racialization among Korean, Pacific Islander, South Asian, and Vietnamese Women
Authors: De La Cruz Monica , Criss Shaniece , Kim Melanie , Thai Nhung , Makres Katrina , Merchant Junaid , Nguyen Thu
Published: April 2024

The people within the Asian and Pacific Islander racial/ethnic category used in the United States are often misrepresented as a monolithic group when, in reality, the group includes people from over 48 different countries with diverse cultures, languages, and customs. Asian and Pacific Islander people experience racism and racialization in nuanced ways that are influenced by immigrant generations, histories of colonization, and origin countries’ relationship with the US. This study examines the racialized experiences of Asian and Pacific Islander women in the United States. Focus groups were held with 21 Korean, Pacific Islander, South Asian, and Vietnamese women in the United States to explore their experiences of racism and racialization. Data were analyzed using an iterative coding and theme-generation process. Findings indicate that among these groups, there is a heightened awareness of racism both toward their own racial/ethnic group as well as toward other minoritized populations, a recognition of the importance of solidarity among people of color to combat racism and the difficulties in sustaining solidarity, and nuanced ways in which different Asian and Pacific Islander people navigate their own racialization.
Public Diplomacy and Democratic Backsliding in Turkey: A Retrospective Look at Government Investment in Soft Power
Authors: Demir Vedat
Published: April 2024

This paper discusses the development of public diplomacy policies and their implementation by the Turkish government through aggregate investment data and within the broader regional and global context in which the country’s policies evolved. Its main aim is to show how regime type is interrelated with foreign policy in general and public diplomacy as a branch of it. Turkey is a fruitful case because the country has experienced significant democratic backsliding since 2011, unlike the first period when the Justice and Development Party (henceforth AKP) came to power in 2002. The discussion over the data on budgets of various institutions responsible for adopting public diplomacy policies shows that cultural and educational public diplomacy received a major increase in investment, especially within the last six years, whereas the budgets for other institutions have fluctuated over the last ten years. Although the paper’s purpose was to provide a comprehensive picture of Turkey’s public diplomacy throughout the AKP rule since 2002, its main data source remains limited to the last decade. Thus, the availability and transparency of the data and its indication of the relationship between regime qualities and public diplomacy policies are also noted.
Exploring the role of gut microbiota in human health
Authors: Amarachukwu Bernaldine Isiaka  , Vivian Nonyelum Anakwenze  , Ugonna Henry Uzoka  , Chiamaka Rosemary Ilodinso  , Mercy Oluwayomi Oso  , Chito Clare Ekwealor  , Chikodili Gladys Anaukwu
Published: April 2024

The study explores the intricate relationship between the human gut microbiota and health. It analyzes the gut microbiota’s roles in digestion, metabolism, immune responses, and overall well-being. The review discusses the composition and diversity of gut microbial communities, emphasizing their symbiotic relationship with the host. It also examines how gut dysbiosis, or microbial imbalance, relates to health conditions like inflammatory bowel diseases and metabolic disorders. The review highlights research methodologies like metagenomics and metabolomics that deepen our understanding of gut microbiota function. It also explores external factors, such as diet and antibiotic use, in shaping the gut microbiome. The review discusses potential therapeutic interventions like probiotics and fecal microbiota transplantation, suggesting a future for personalized medicine. By synthesizing existing knowledge, the review aims to advance understanding of the gut microbiota’s role in health and suggest future research and interventions.
Thermophilic lipases in industrial applications: Stutzerimonas stutzeri as a Case Study in Nigeria and the US
Authors: Deborah Aanuoluwa Soyombo
Published: April 2024

Thermophilic lipases derived from Stutzerimonas stutzeri have garnered significant attention in recent years due to their robustness and efficiency in various industrial applications. This review delves into the research, development, and application of these enzymes, with a comparative analysis between Nigeria and the United States. In both nations, researchers have explored the enzymatic properties of thermophilic lipases from Stutzerimonas stutzeri, aiming to optimize their performance for diverse industrial processes. The research encompasses studies on enzyme purification, characterization, and genetic engineering to enhance catalytic activity and stability under extreme conditions. Additionally, efforts have been directed towards understanding the enzyme's structure-function relationship to tailor it for specific applications. In Nigeria, the focus on thermophilic lipases from Stutzerimonas stutzeri has been primarily driven by the need for sustainable biotechnological solutions in various industries, including food, pharmaceuticals, and biofuel production. The enzymes' thermostability makes them particularly suitable for high-temperature processes prevalent in Nigeria's tropical climate, offering potential for cost-effective and eco-friendly alternatives to conventional chemical catalysts. In contrast, the United States has witnessed extensive research and development in thermophilic lipases for industrial applications, with a strong emphasis on biocatalysis in the pharmaceutical, detergent, and biofuel sectors. The advanced infrastructure and investment in biotechnology have facilitated the commercialization of Stutzerimonas stutzeri lipases, leading to their integration into various industrial processes to improve efficiency and sustainability. Despite the similarities in research objectives, disparities exist in the technological advancements and industrial utilization of thermophilic lipases from Stutzerimonas stutzeri between Nigeria and the US. While Nigeria faces challenges related to limited resources and infrastructure, the US benefits from well-established research institutions and industrial networks, enabling accelerated innovation and commercialization. Bridging these gaps through international collaborations and knowledge exchange could facilitate the widespread adoption of thermophilic lipases for sustainable industrial development globally.
Successful conservative treatment for a non-exteriorised Vesicocutaneous fistula
Authors: Mohammed Alae RAYANE  , Othmane CHAMA  , Jalal Eddine AMMARI  , Soufiane MELLAS  , Mostapha AHSAINI  , Mohammed Fadl TAZI  , Mohammed Jamal EL FASSI  , Moulay Hassan FARIH
Published: April 2024

Cystic cutaneous fistula refers to an abnormal passageway or tunnel that forms between a cyst and the skin surface. A cyst is a closed sac or pocket containing fluid, air, or other substances, and when a connection forms between this cyst and the outer skin, it leads to the development of a fistula. The diagnosis is mainly clinical and X ray based. Primarily affects both male and female adults. Mainly caused by infection, trauma and history of recent trans cystic or cystic surgery for bladder stones, benign prostatic hyperplasia and other causes. Although treatment usually includes antibiotics, percutaneous or open surgery procedures may be needed to treat the fistula.
Initially metastatic bladder carcinoma in a 31-year-old patient.
Authors: Mohammed Alae RAYANE  , Rayane Ouaddane ALAMI  , Jalal Eddine AMMARI  , Soufiane MELLAS  , Mostapha AHSAINI  , Mohammed Fadl TAZI  , Mohammed Jamal EL FASSI  , Moulay Hassan FARIH
Published: April 2024

Bladder cancer is the fifth most common malignancy, peaks in incidence after the sixth decade of life. reports of the clinical behavior of bladder cancer specifically in young patients are restricted to small series. While some hereditary syndromes such as Li-Fraumeni or retinoblastoma carry an increased risk of urothelial tumors at an early age. their low prevalence means that few clinicians see such cases. This pathology occurs mainly in the male patient and with a prevalence of 4 % in the male patient younger than 40 years old. The same identified factors found in the elderly patient were identified in the youthful patients. Clinically, like in the older patients, hematuria, irritative symptoms (urgency, frequency, dysuria) and clinical decline were described before the confirmed diagnosis. Bladder tumors are usually superficial before the age of 40 therefore have a low aggressivity rate. Treatment of invasive bladder cancer in young patients does not differ from the treatment at an old age. Also, the prognosis of patients under 40 years of age with bladder carcinoma is claimed to be better than of those presenting in later life.
A GIS-based analysis of heavy metals around Otukpo rice mill in Benue state
Authors: Augustine Abah Odeh  , Jasini Ali Alwadood  , Michael Nnaemeka Ihenacho  , Epsar Philip Kopteer  , Udya Aniya  , James Adah John  , Nkechinyere Gift Nwagwu  , Sumaiyat Kpanja Abdullahi  , Halimat Ifedolapo Oriola  , Vivian Aaron Ibrahim  , Elizabeth Rizga Jackson  , Kamila Abba Tukur  , Kikelomo Oluwabokola Adebo  , Chinenye Ann Nweke  , Tochukwu Ikediashi  , Amarachi Christiana Ikwuka  , Philip Okoh Amodu
Published: April 2024

Heavy metals are primarily sourced from natural pedo-geochemical backgrounds and anthropogenic occurrences like composting, sewage sludge, aerosol deposition, and waste animal manure. The study aims to determine the heavy metals within the rice mill in Otukpo to understand the spatial distribution with the objectives to examine the heavy metals within the identified activity areas in the Otukpo rice mill, to determine the spatial distribution of heavy metals within the study area and to compare heavy metal values with the acceptable limits. Soil samples were collected from ten locations at Otukpo Rice Mill to analyze heavy metal concentrations. The samples were collected using sterile bottles and a stainless trowel, and the soil samples were analyzed for the concentrations of Cadmium, Copper, Lead, Nickel, Zinc, Mercury, Iron, Arsenic, and Chromium using the Atomic Absorption Spectrophotometry method. The result was analyzed using interpolation to see the variation of the Heavy metals within the various activity areas. The result of the study reveals that Iron has the highest concentration at the Entrance point and lowest at the Generator house with a range value of 3.92 – 1.12mg/kg respectively. The highest concentration of Zinc was recorded at the Mechanic workshop while the lowest is at the Drying point with a range value of 0.135 – 0.872mg/kg respectively. The Husk dumpsite recorded the highest concentration of Copper (0.666mg/kg) with the Drying point recording the least (0.088 mg/kg). The study reveals uneven concentrations and highlights the effectiveness of the Geographic Information System in mapping heavy metal concentrations.
Thyroid storm: Report of four cases in two health institutions, Barranquilla
Authors: Vanessa Rocío Villanueva Guerrero  , Jennifer Patricia Vargas Gómez  , Ilich Vladimir Bayuelo Charris  , Rusvelt Vargas Moranth  , Lorena Rocío Orozco Álvarez  , Germán José Pertúz Rebolledo
Published: April 2024

Thyroid storm or thyrotoxic crisis is a life-threatening condition, characterized by signs and symptoms of thyrotoxicosis associated with multiorgan dysfunction, occurs as a complication of hyperthyroidism and due to its high risk of mortality, merits timely diagnosis and early treatment. Among the main causes of thyroid storm is Graves' Basedow's disease, which is associated with triggering factors such as non-adherence to medical therapy. The diagnosis is based on clinical manifestations and increased thyroid hormones, but thyroid hormone levels are not related to the severity of the condition, so sensitive scoring systems have been developed to support the diagnostic approach. In this review, we analyze a series of patients with thyroid storm in which half of the patients have a fatal outcome, demonstrating the association with high mortality.
Factors affecting women's first childbearing age limit (based on Colombo District)
Authors: H.A. Dimani Tharuka Hapuarachchi
Published: April 2024

This study explores the determinants influencing the age at which women have their first child in the Colombo district of Sri Lanka. Drawing upon demographic, social, and economic factors, the research employs a mixed-methods approach, including demographic analysis, chi-square analysis, multiple regression analysis, and literature review. Findings reveal that factors such as education level, age at marriage, occupation status, and monthly household income significantly impact the age at first childbirth. Specifically, education emerges as a primary determinant, with higher levels of education associated with delayed childbirth. Additionally, residential location and type of marriage play roles in shaping the timing of the first childbirth. The study underscores the multifaceted nature of these determinants and highlights the importance of understanding the interplay between demographic, social, and economic factors in informing targeted interventions to promote reproductive health and well-being among women in Sri Lanka. Based on the conclusions drawn, recommendations are provided for implementing education initiatives, fostering economic empowerment, strengthening family planning services, supporting love marriages, and advocating for policy interventions. Implementation of these recommendations can address underlying factors influencing the age at which women have their first child, ultimately promoting women's health, empowerment, and well-being in the Colombo district and beyond.
The role of policy and regulation in promoting green buildings
Authors: Deborah Aanuoluwa Soyombo
Published: April 2024

Green buildings play a crucial role in sustainable development by reducing energy consumption, minimizing environmental impact, and enhancing occupant health and well-being. This review explores the role of policy and regulation in promoting green buildings, highlighting the importance of government intervention in driving sustainable building practices. Government policies and regulations play a pivotal role in shaping the adoption of green building practices. Through a combination of mandates, incentives, and standards, governments can encourage the construction and renovation of buildings that prioritize energy efficiency, water conservation, and environmental sustainability. Mandatory building codes and standards are among the most effective tools governments use to promote green buildings. These codes set minimum requirements for energy performance, water efficiency, and indoor environmental quality, ensuring that new constructions and major renovations meet established sustainability criteria. In addition to mandatory standards, governments also use financial incentives to encourage green building practices. These incentives may include tax credits, grants, or subsidies for building owners and developers who incorporate sustainable design features or achieve green building certifications. Furthermore, governments can influence the market through procurement policies that prioritize green buildings for public projects. By leading by example, governments can create a ripple effect in the private sector, encouraging more developers and building owners to embrace sustainable building practices. Overall, the role of policy and regulation in promoting green buildings is essential for advancing sustainable development goals. By setting clear standards, providing incentives, and leading by example, governments can create an environment where green buildings are the norm rather than the exception, leading to a more sustainable built environment for future generations.