bluuebunny/crossref_metadata_2025 huggingface dataset:
Structural, Thermal and Optical Properties of Mn2+ Doped Methacrylic Acid – Ethyl Acrylate (MAA:EA) Copolymer Films
Authors: Madhava Kumar Y. , Bhagyasree K. , Gopal N.O. , Ramu Ch. , Nagabhushana H.
Published: December 2016

Pure and Mn2+ doped Methacrylic Acid Ethylacrylate (MAA:EA) copolymer films were prepared by using the solution cast technique. Investigations were conducted using DSC, TGA, XRD, FTIR, UV–Vis, SEM and EPR. Thermal properties of these films were investigated with differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Using the DSC thermograms, glass transition temperature (Tg
) and melting temperature (Tm
) of copolymer films were measured. Thermogravimetric curves of the pure and Mn2+ doped MAA:EA copolymer showed two distinct steps of weight loss. The optical absorbance of the pure and Mn2+ doped films were measured in the 200–800 nm wavelength range. The values of absorption edge, direct and indirect band gaps were calculated. The optical band gap decreased with the increase of mol% of Mn2+ ions. The enhanced amorphous nature of the doped copolymer has been identified from X-ray diffraction analysis. FTIR spectral studies of pure and Mn2+ doped MAA:EA copolymer films display significant structural changes within the copolymer film indicating the complexation. The morphology of the copolymer samples was examined by scanning electron microscopy (SEM). EPR spectra of all the doped samples exhibit a single absorption line centered at g=2.005. The observed variation in the EPR signal intensity is due to the existence of interacting paramagnetic centers.
Sex-Dependent Regulation of Aromatase-Mediated Synaptic Plasticity in the Basolateral Amygdala
Authors: Bender Roland A. , Zhou Lepu , Vierk Ricardo , Brandt Nicola , Keller Alexander , Gee Christine E. , Schäfer Michael K.E. , Rune Gabriele M.
Published: December 2016

The basolateral amygdala (BLA) integrates sensory input from cortical and subcortical regions, a function that requires marked synaptic plasticity. Here we provide evidence that cytochrome P450 aromatase (AROM), the enzyme converting testosterone to 17β-estradiol (E2), contributes to the regulation of this plasticity in a sex-specific manner. We show that AROM is expressed in the BLA, particularly in the basolateral nucleus (BL), in male and female rodents. Systemic administration of the AROM inhibitor letrozole reduced spine synapse density in the BL of adult female mice but not in the BL of male mice. Similarly, in organotypic corticoamygdalar slice cultures from immature rats, treatment with letrozole significantly reduced spine synapses in the BL only in cultures derived from females. In addition, letrozole sex-specifically altered synaptic properties in the BL: in acute slices from juvenile (prepubertal) female rats, wash-in of letrozole virtually abolished long-term potentiation (LTP), whereas it did not prevent the generation of LTP in the slices from males. Together, these data indicate that neuron-derived E2 modulates synaptic plasticity in rodent BLA sex-dependently. As protein expression levels of AROM, estrogen and androgen receptors did not differ between males and females and were not sex-specifically altered by letrozole, the findings suggest sex-specific mechanisms of E2 signaling.

SIGNIFICANCE STATEMENTThe basolateral amygdala (BLA) is a key structure of the fear circuit. This research reveals a sexually dimorphic regulation of synaptic plasticity in the BLA involving neuronal aromatase, which produces the neurosteroid 17β-estradiol (E2). As male and female neurons in rodent BLA responded differently to aromatase inhibition bothin vivoandin vitro, our findings suggest that E2 signaling in BLA neurons is regulated sex-dependently, presumably via mechanisms that have been established during sexual determination. These findings could be relevant for the understanding of sex differences in mood disorders and of the side effects of cytochrome P450 aromatase inhibitors, which are frequently used for breast cancer therapy.
Differences in Glomerular-Layer-Mediated Feedforward Inhibition onto Mitral and Tufted Cells Lead to Distinct Modes of Intensity Coding
Authors: Geramita Matthew , Urban Nathan N.
Published: December 2016

Understanding how each of the many interneuron subtypes affects brain network activity is critical. In the mouse olfactory system, mitral cells (MCs) and tufted cells (TCs) comprise parallel pathways of olfactory bulb output that are thought to play distinct functional roles in odor coding. Here, in acute mouse olfactory bulb slices, we test how the two major classes of olfactory bulb interneurons differentially contribute to differences in MC versus TC response properties. We show that, whereas TCs respond to olfactory sensory neuron (OSN) stimulation with short latencies regardless of stimulation intensity, MC latencies correlate negatively with stimulation intensity. These differences between MCs and TCs are caused in part by weaker excitatory and stronger inhibitory currents onto MCs than onto TCs. These differences in inhibition between MCs and TCs are most pronounced during the first 150 ms after stimulation and are mediated by glomerular layer circuits. Therefore, blocking inhibition originating in the glomerular layer, but not granule-cell-mediated inhibition, reduces MC spike latency at weak stimulation intensities and distinct temporal patterns of odor-evoked responses in MCs and TCs emerge in part due to differences in glomerular-layer-mediated inhibition.

SIGNIFICANCE STATEMENTOlfactory bulb mitral and tufted cells display different odor-evoked responses and are thought to form parallel channels of olfactory bulb output. Therefore, determining the circuit-level causes that drive these differences is vital. Here, we find that longer-latency responses in mitral cells, compared with tufted cells, are due to weaker excitation and stronger glomerular-layer-mediated inhibition.
Ar išmoksime mąstyti kaip senovės graikai? Unikali dviejų mąstytojų helenofilų knyga apie filosofijos likimą – jos pradžią ir sugrįžimą
Authors: Kardelis Naglis
Published: December 2016

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2007–2008 metai Klasikinės filologijos katedroje | 2007–2008 metais katedros dėstytojų išleistos knygos
Authors: 2008 Literatūra
Published: December 2016

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Zur Logik des Preisens in der Dichtung Simon Dachs
Authors: Meržvinskaitė Birutė
Published: December 2016

Straipsnyje aptariamos logikos, retorikos ir poetikos sąsajos XVII a. baroko poeto Simono Dacho progi­niuose eilėraščiuose. Logika suprantama pirmiausia kaip argumentavimo ir mąstymo menas, susidedantis iš sąvokų, sprendinių ir išvadų. Teigiama, kad dėl bū­dingo baroko menui ypatingo dėmesio tradicijai kūry­binė kompetencija sutapo su recepcine kompetencija, tiesa – su metodu. Dacho kūryboje poetas palyginamas su filosofu, siekiančiu visuotinumo, apibendrinimų, ir istoriku, apmąstančiu ir įamžinančiu raštu veiksmus ir įvykius, nusipelniusius šlovės ir amžinumo. Pabrėžia­ma, kad Dachas teikė pirmenybę faktui, o ne išmonei. Jo poezijos autentiškumas ir paprastumas siejami su literatūros pasaulietiškėjimo tendencijomis, moder­nios autorystės sampratos užuomazgomis.Dacho eilėse atsiskleidžianti žmogaus samprata vaizduoja žmogų, priklausantį gamtos, žemiškajam ir dangiškajam pasauliams. Adresatų šlovė neatsie­jama nuo jų gerų darbų, lyginamų su mitologinių ir istorinių personažų žygiais, šlovinimo poetika ir lo­gika, baroko vaizdiniais įrašomų į atminties, tiesos ir teisingumo sąvokų sklaidą.
DIE AKADEMIE IM ZEITALTER DER GLOBALISIERUNG: ZUR ROLLE VON LITERATURUND KULTURWISSENSCHAFTEN
Authors: Wilke Sabine
Published: December 2016

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Preface / Vorwort
Authors: Šeškauskienë Inesa , Žeimantienë Vaiva
Published: December 2016

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Acute Liver Failure Meets SOPH Syndrome: A Case Report on an Intermediate Phenotype
Authors: Kortüm Fanny , Marquardt Iris , Alawi Malik , Korenke Georg Christoph , Spranger Stephanie , Meinecke Peter , Kutsche Kerstin
Published: December 2016

Acute liver failure (ALF) is a life-threatening condition in the absence of preexisting liver disease in children. The main clinical presentation comprises hepatic dysfunction, elevated liver biochemical values, and coagulopathy. The etiology of ALF remains unclear in most affected children; however, the recent identification of mutations in the neuroblastoma amplified sequence (NBAS) gene in autosomal recessively inherited ALF has shed light on the cause of a subgroup of fever-triggered pediatric ALF episodes. Previously, biallelic mutations in NBAS have been reported to be associated with a syndrome comprising short stature, optic atrophy, and Pelger-Huët anomaly (SOPH) specifically occurring in the Yakut population. No hepatic phenotype has been observed in individuals with this disorder who all carry the homozygous NBAS founder mutation c.5741G>A [p.(Arg1914His)]. We present the case of a 4-year-old girl with the cardinal features of SOPH syndrome: characteristic facial dysmorphism, postnatal growth retardation, delay of bone age, slender long bones, optic atrophy, and Pelger-Huët anomaly. During the first 2 years of her life, a series of infections with episodes of fever were accompanied by elevated liver enzyme levels, but hyperammonemia, hypoglycemia, coagulopathy, or encephalopathy suggestive of acute and severe liver disease were never observed. Whole exome sequencing in the patient revealed compound heterozygosity of the 2 NBAS variants, p.(Arg1914His) and p.(Glu943*). This case highlights the variability of clinical presentation associated with NBAS deficiency. Absence of severe liver problems in this case and SOPH-affected Yakut subjects suggests that individuals carrying the NBAS missense mutation p.(Arg1914His) are less susceptible to developing ALF.
Targeting heme oxygenase-1 in early diabetic nephropathy in streptozotocin-induced diabetic rats
Authors: Abo El Gheit R , Emam MN
Published: December 2016

Diabetic nephropathy (DN) is one of the most common microvascular diabetic complications. This study was designed to evaluate the possible protective effect and underlying mechanisms of HO-1 induction in streptozotocin (STZ)-induced early DN in rats. The diabetic rats were divided into three groups: STZ-diabetic, cobalt protoporphyrin (CoPP)-treated diabetic, and zinc protoporphyrin IX (ZnPP)-treated diabetic groups. Compared to the STZ-diabetic group, CoPP-induced HO-1 upregulation improved the diabetic state and renal functional parameters, suppressed the renal proinflammatory marker, NF-κB, abrogated the elevated renal hydroxyprolin, and decreased the enhanced renal nicotinamide adenine dinucleotide phosphate oxidase activity with parallel reduction of urinary oxidative stress markers. On the contrary, treatment with ZnPP abrogated HO-1 levels, aggravated the diabetic condition with further increases in renal oxidative stress, fibrotic and inflammatory markers, and exacerbated renal dysfunction in diabetic animals. These findings suggest that the reduced diabetic renal injury upon HO-1 induction implicates the role of HO-1 induction as a potential treatment for DN.
Amphibia, Anura, Hylidae, Scarthyla vigilans (Solano, 1971): range extension and new country record for Trinidad, West Indies, with notes on tadpoles, habitat, behavior and biogeographical significance
Authors: Smith Joanna M. , Downie J. Roger , Dye Rebecca F. , Ogilvy Victoria , Thornham Daniel G. , Rutherford Michael G. , Charles Stevland P. , Murphy John C.
Published: December 2016

We report a range extension and new country record for Scarthyla vigilans in Trinidad, West Indies. The species was previously known only from populations on mainland South America. We include notes on behavior, habitat and tadpole development, and discuss the biogeographical significance of the species’ presence in Trinidad, particularly with respect to consequences for understanding colonization events on this Caribbean island.
Amphibia, Anura, Leptodactylidae, Leptodactylus syphax Bokermann, 1969: distribution extension and geographic distribution map
Authors: Andrade Etielle B. , Guimarães Rafael , Leite Jr João Manoel A. , Leite José Roberto S. A.
Published: December 2016

Leptodactylus syphax is a mid-sized frog that inhabits open rocky areas in central, southeastern and northeastern Brazil, besides southern Paraguay and eastern Bolivia. Here we reported an adult male from Parque Municipal Cachoeira do Bota Fora, Piripiri municipality, state of Piauí, northeastern Brazil, expanding the known distribution of Leptodactylus syphax ca. 320 km northwards.
First record of Scartella itajobi Rangel and Mendes, 2009 (Perciformes: Blenniidae) from São Pedro e São Paulo Archipelago, Brazil
Authors: Filho Paulo Augusto De Lima , Soares Rodrigo Xavier , Molina Wagner Franco , Mendes Liana De Figueiredo
Published: December 2016

This article presents the first record of the blenniid Scartella itajobi in the São Pedro e São Paulo Archipelago, located off the state of Rio Grande do Norte, northeastern Brazil. As a result, the species distribution is extended 610 km northeast. The number of species of Blenniidae known to occur in São Pedro e São Paulo Archipelago is three, whereas the number of endemic fish species shared by São Pedro e São Paulo, Fernando de Noronha, and Rocas Atoll now stands at two.
Promecops claviger Hustache, 1929 (Coleoptera: Curculionidae): first register in Brazil and first host plant register
Authors: Barreto Marliton Rocha , Cavalet Fábio
Published: December 2016

For the first time in Brazil and in soybean plants (Glycine max (L.) Merr.), the weevil Promecops claviger Hustache has been identified. The incidence occurred in the city of Sinop, Mato Grosso (11°48’14,64” S, 55°34’55,93” W), in October 2010.
Amphibia, Anura, Bufonidae, Melanophryniscus spectabilis Caramaschi and Cruz, 2002: distribution extension and geographic distribution map
Authors: Giasson Luís Olímpio Menta , Kunz Tobias Saraiva , Ghizoni-Jr Ivo Rohling
Published: December 2016

We present here the first records of Melanophryniscus spectabilis out of its type locality and evidences of a restricted distribution for this species. We also discuss its conservation status.
Checklist of orchid bees (Hymenoptera: Apidae) of “Lago do Silêncio” Area, Boca do Acre, Amazonas, Brazil
Authors: Storck-Tonon Danielle , Silva Marilene Vasconcelos , Morato Elder Ferreira
Published: December 2016

This study presents a list of euglossine-bee species collected in the Lago do Silêncio region, municipality of Boca do Acre, in the Brazilian state of Amazonas, southwestern Amazonia. Euglossine males were attracted to odoriferous baits on December 3 and 4, 2004. A total of 234 individuals belonging to four genera and 25 species were collected. Despite the small sampling effort, the local euglossine fauna is abundant and rich, when compared to those of other areas in the Brazilian Amazonia where higher sampling efforts were performed. Therefore, further studies in the region can be important for improving our knowledge of the bees in the Amazon region.
Fishes of the Kwilu River (Kasai basin, central Africa): A list of species collected in the vicinity of Kikwit, Bandundu Province, Democratic Republic of Congo
Authors: Munene José Justin Mbimbi Mayi , Stiassny Melanie L. J.
Published: December 2016

A list of fishes collected in the vicinity of Kikwit on the Kwilu River, a large left bank tributary of the Kasai River in the Democratic Republic of Congo is provided. One hundred and thirteen species distributed in 21 families are reported, and of these 29 species are recognized as representing new records for the region. Lack of up-to-date taxonomic and distributional knowledge of African fishes, a problem particularly acute in the central Congo basin, is clearly reflected in this high number of range extensions. While preliminary, this contribution serves as a useful starting point for efforts to understand the ichthyofaunal composition and biogeographic history of the Kasai system; one of the most poorly documented river systems in central Africa.
TEKNIK ISOLASI BAKTERI BERCAHAYA Vibrio harveyi PADA LARVA KEPITING BAKAU, Scy
Authors: Suarjana Putu
Published: December 2016

Abstrak bisa diliat di Lampiran
PEMBUATAN MEDIA DAN PEREAKSI UNTUK ISOLASI DAN IDENTIFIKASI BAKTERI, Vibrio sp.
Authors: Nurjanna Nurjanna
Published: December 2016

Abstrak bisa dilihat di Lampiran
KERAGAMAN GENOTIPE TIGA GENERASI IKAN RAINBOW KURUMOI (Melanotaenia parva) HASIL DOMESTIKASI BERDASARKAN RAPD; Genotype Diversity in Three Generations of Domesticated Kurumoi Rainbow Fish (Melanotaenia parva) Based on RAPD Method.
Authors: Hayuningtyas Erma Primanita , Kadarini Tutik
Published: December 2016

Ikan rainbow Kurumoi (Melanotaenia parva) adalah ikan endemik Danau Kurumoi, Papua Barat, Indonesia. Balai Penelitian dan Pengembangan Budidaya Ikan Hias (BPPBIH), Depok telah berhasil melakukan domestikasi dan menghasilkan beberapa generasi ikan rainbow Kurumoi. Ikan rainbow Kurumoi memijah secara alami, sehingga kemungkinan terjadinya inbreeding tinggi. Oleh karena itu, sangatlah penting untuk mengevaluasi keragaman genetik ikan rainbow Kurumoi. Penelitian ini bertujuan untuk mengetahui kualitas genetik dengan mengevaluasi keragaman genotipe tiga generasi ikan rainbow Kurumoi menggunakan metode RAPD (Randomly Amplified Polymorphic DNA) dengan tiga jenis primer, yaitu: OPA-18, OPZ-5, dan OPZ-13. Setiap generasi diambil 10 ekor ikan secara acak. Hasil penelitian ditemukan bahwa keragaman genotipe ikan generasi pertama (69,25%) relatif lebih rendah (P>0,05) daripada generasi kedua (76,9%) dan ketiga (76,9%). Nilai heterozigositas cenderung meningkat dari generasi ke generasi. Heterozigositas ikan generasi pertama adalah 0,21; generasi kedua sebesar 0,24; dan generasi ketiga sebesar 0,25. Jarak genetik terjauh adalah antara generasi pertama dan generasi ketiga, yaitu sebesar 0,19. Dengan demikian, proses domestikasi yang telah dilakukan tidak menyebabkan penurunan keragaman genotipe ikan rainbow Kurumoi.Kurumoi rainbow fish (Melanotaenia parva) is an endemic species from Kurumoi Lake, West Papua, Indonesia. Research and Development for Ornamental Fish Culture, Depok has successfully domesticated and produce Kurumoi rainbow fish for several generations. This fish is breed naturally, inbreeding probability is highly occure. It is important to evaluate genetic diversity of Kurumoi rainbow fish. Aim of the research was to evaluate genotype diversity at three generations of Kurumoi rainbow fish using RAPD (Randomly Amplified Polymorphic DNA) method with three primers, namely OPA-18, OPZ-5, and OPZ-13. In the research, 10 fishes were randomly taken from each generation. The research found that genotype diversity of fish first generation (69.25%) was relatively lower (P>0.05) than second (76.9%) and third (76.9%) generations. Heterozygosity value tended to increase by generation to generation. Heterozygosity at first generation was 0.21, 0.24 at second generation and 0.25 at third generation. The highest genetic distance was between the first and third generation (0.19). Thus, the domestication process that has been done does not cause a decrease in genotype diversity of Kurumoi rainbow fish.
PERFORMA PERTUMBUHAN KRABLET KEPITING BAKAU (Scylla olivacea) DENGAN FREKUENSI PEMBERIAN PAKAN BERBEDA PADA STADIA PENDEDERAN
Authors: Kamaruddin Kamaruddin , Usman Usman , Laining Asda
Published: December 2016

Salah satu upaya untuk menekan tingkat kanibalisme dan memicu pertumbuhan krablet kepiting bakau adalah dengan pemberian pakan yang cukup, baik jumlah maupun mutu. Penelitian ini bertujuan mengevaluasi kinerja pertumbuhan dan sintasan krablet kepiting bakau dengan frekuensi pemberian pakan berbeda pada stadia pendederan. Hewan uji berupa krablet kepiting bakau dengan bobot awal 0,037 ± 0,005 g dan lebar karapas awal 3,43 ± 0,42 mm; menggunakan sembilan unit fiber gelas dengan ukuran masing-masing 1 m x 1 m x 0,5 m. Hewan uji ditebar dengan kepadatan 50 ekor/m2. Perlakuan yang diujicobakan adalah frekuensi pemberian pakan per hari, yaitu: (A) dua kali (pukul 08.00 dan 18.00), (B) tiga kali (pukul 08.00, 13.00, dan 18.00), dan (C) empat kali (pukul 08.00, 13.00, 18.00, dan 23.00). Pakan yang digunakan berupa pelet dengan kandungan protein kasar 46,5%; lemak 8,8%; dan energi total 18,8 MJ/kg. Dosis pakan harian sebanyak 30%-15% bobot badan secara menurun hingga akhir penelitian. Setelah lima minggu pemeliharaan didapatkan hasil yang menunjukkan bahwa pertumbuhan, sintasan, konsumsi pakan harian, rasio konversi pakan, dan rasio efisiensi protein tidak menunjukkan perbedaan yang nyata (P>0,05) di antara perlakuan. Namun demikian, pemberian pakan empat kali sehari cenderung menunjukkan pertumbuhan yang lebih cepat dan dengan ukuran krablet yang lebih seragam.One of technique to reduce cannibalism and to stimulate the growth of mud crab is by providing an adequate feed that meet the requirement level of the crablet. The objecive of this study was to evaluate the growth and survival of crablet fed artificial diet with different feeding frequencies during nursery stage. The treatments were different feeding frequencies namely (A) 2 times (08:00 and 18:00), (B) 3 times (08:00, 13:00, and 18:00 ) and (C) 4 times (08:00, 13:00, 18:00 and 23:00). Feeding rate was from 30 to 15 % of biomass/day. Feed used in the feeding trial was a dry pellet (1.2 mm size) containing 46.5 % crude protein, 8.8 % lipid and gross energy 18.8MJ / kg. Mud crab crablet with initial body weight of 0.037 ± 0.005 g with carapace width of 3.43 ± 0.042 mm were stocked into nine fiber tanks (1 m x 1 m x 0.5 m) with density of 50 crablets / tank. After 5 weeks of feeding trial, results of the experiment showed that growth rate, survival, feed intake, feed conversion ratio and protein efficiency ratio were not significantly difference (P> 0.05) among the treatments. However, growth performance of crablet fed 4 times/day increased and resulted uniformsize of crablet.
Mixed Blessings: Indigenous Encounters with Christianity in Canada, edited by Tolly Bradford and Chelsea Horton
Authors: Caufield Catherine
Published: December 2016

Mixed Blessings: Indigenous Encounters with Christianity in Canada, edited by Tolly Bradford and Chelsea Horton. University of British Columbia Press, 2016. 226 pp., Pb. $29.65 ISBN-13: 9780774829403
HLA-DRB1*15:01 and HLA-DRB3*02:02 in PLA2R-Related Membranous Nephropathy
Authors: Le Wei-Bo , Shi Jing-Song , Zhang Tao , Liu Lei , Qin Hua-Zhang , Liang ShaoShan , Zhang Yuan-Wei , Zheng Cun-Xia , Jiang Song , Qin Wei-Song , Zhang Hai-Tao , Liu Zhi-Hong
Published: December 2016

Idiopathic membranous nephropathy (MN) is associated with HLA; however, the HLA allele involved remains unknown. To identify the HLA risk alleles associated with phospholipase A2 receptor (PLA2R)-related MN in the Chinese population, we sequenced the entire MHC region in DNA samples from 99 patients with PLA2R-related MN, 50 patients with PLA2R-unrelated MN, and 100 healthy subjects. Two HLA risk alleles, HLA-DRB1*15:01 and HLA-DRB3*02:02, independently and strongly associated with an increased risk of PLA2R-related MN. After adjusting for HLA-DRB1*15:01 and HLA-DRB3*02:02, no other alleles showed significant association with PLA2R-related MN. A replication study in an independent cohort of 293 participants with PLA2R-related MN and 285 healthy controls validated these findings. In a joint analysis, a multivariate logistic regression model confirmed that HLA-DRB1*15:01 (odds ratio [OR], 24.9; 95% confidence interval [95% CI], 15.3 to 42.6; P=2.3×10−35) and HLA-DRB3*02:02 (OR, 17.7; 95% CI, 11.0 to 30.3; P=8.0×10−29) independently and strongly associated with PLA2R-related MN. As many as 98.7% of patients with PLA2R-related MN, compared with 43.9% of control subjects, carried at least one HLA risk allele. Subjects with either risk allele had higher odds of developing PLA2R-related MN than those without a risk allele (OR, 98.9; 95% CI, 44.4 to 281.7; P=2.5×10−23). These HLA risk alleles also associated with the age at disease onset in patients with PLA2R-related MN. In conclusion, our findings provide clear evidence that the HLA-DRB1*15:01 and HLA-DRB3*02:02 alleles independently and strongly associate with PLA2R-related MN in the Chinese population.
Unique Transcriptional Programs Identify Subtypes of AKI
Authors: Xu Katherine , Rosenstiel Paul , Paragas Neal , Hinze Christian , Gao Xiaobo , Huai Shen Tian , Werth Max , Forster Catherine , Deng Rong , Bruck Efrat , Boles Roger W. , Tornato Alexandra , Gopal Tejashree , Jones Madison , Konig Justin , Stauber Jacob , D’Agati Vivette , Erdjument-Bromage Hediye , Saggi Subodh , Wagener Gebhard , Schmidt-Ott Kai M. , Tatonetti Nicholas , Tempst Paul , Oliver Juan A. , Guarnieri Paolo , Barasch Jonathan
Published: December 2016

Two metrics, a rise in serum creatinine concentration and a decrease in urine output, are considered tantamount to the injury of the kidney tubule and the epithelial cells thereof (AKI). Yet neither criterion emphasizes the etiology or the pathogenetic heterogeneity of acute decreases in kidney excretory function. In fact, whether decreased excretory function due to contraction of the extracellular fluid volume (vAKI) or due to intrinsic kidney injury (iAKI) actually share pathogenesis and should be aggregated in the same diagnostic group remains an open question. To examine this possibility, we created mouse models of iAKI and vAKI that induced a similar increase in serum creatinine concentration. Using laser microdissection to isolate specific domains of the kidney, followed by RNA sequencing, we found that thousands of genes responded specifically to iAKI or to vAKI, but very few responded to both stimuli. In fact, the activated gene sets comprised different, functionally unrelated signal transduction pathways and were expressed in different regions of the kidney. Moreover, we identified distinctive gene expression patterns in human urine as potential biomarkers of either iAKI or vAKI, but not both. Hence, iAKI and vAKI are biologically unrelated, suggesting that molecular analysis should clarify our current definitions of acute changes in kidney excretory function.
Identity, Identification and Identifiers: The Global Legal Entity Identifier System
Authors: Kennickell Arthur B.
Published: December 2016

Identity is a critical concept in the rational interactions of any set of objects involving subject-object relationships. The objects must be distinguished according to some framework in order for such relationships to have meaning. In the world of economic systems, relationships such as ownership and responsibility require specific parties to be fixed with a high degree of certainty. This need is particularly strong in financial markets, where transactions can take place in nanoseconds. This paper discusses a particular framework for defining economic actors, the Global Legal Entity Identifier System (GLEIS), which was initiated for the purpose of creating greater transparency about participants in financial markets and transactions.
Digital games and learning mathematics: Student, teacher and parent perspectives
Authors: Yong Su Ting , Gates Peter , Harrison Ian
Published: December 2016

The purpose of this study was to explore the potential use of digital games in learning mathematics at secondary school level in Malaysia. Three secondary school students, three mathematics teachers and three parents were interviewed in this study. All the participants were asked for their views and experiences in mathematics, technology usage and the use of digital games in learning mathematics. The results suggested that students were supportive and positive towards the use of computer games in learning mathematics. Nevertheless, parents preferred conventional teaching approach, in which they recognized personal communication and socialization as a significant component in learning. Although the teachers did not go on to oppose the idea of using computer games for teaching mathematics, they still perceived the use of discursive approaches as the best teaching approach for learning mathematics with digital technologies at best a possible additional complementary feature. In view of that, the combination of classroom teaching and computer games might the best mathematics pedagogy.
Comparação granulométrica com vistas para o entendimento sedimentar em áreas úmidas no Pantanal da Nhecolândia-MS
Authors: Boni Paola Vicentini , Gradella Frederico dos Santos , Decco Hermiliano Felipe
Published: December 2016

O Pantanal é uma área alagável conhecida no mundo, está localizado na da Bacia do Alto Paraguai. A planície pantaneira é uma bacia sedimentar, deprimida e plana caracterizada principalmente por passar por inundações anuais. Este trabalho tem como objetivo comparar duas áreas do Pantanal da Nhecolândia, leste e sudoeste. Realizou-se trabalho de campo para coleta de amostras com trado do tipo holandês, fazendo a descrição de cor com auxílio da tabela de Munsell, textura e umidade. Após, ocorreu a análise granulométrica para avaliar os resultados obtidos elaborando o histograma para verificar a quantidade e tamanhos dos grãos. Como resultado, percebeu-se que as áreas possuem características sutilmente semelhantes, com diferenças na quantidade da espessura dos grãos ao longo do perfil amostrado, evidenciando nesse ponto, as possíveis diferenças entre duas áreas do Pantanal da Nhecolândia. Palavras-chave: análise granulométrica; geomorfologia; sedimentação. Particle size comparison with objective to understanding sedimentation in region of Nhecolândia in the Pantanal wetlands ABSTRACTThe Pantanal is considered a biggest wetland in the world, is located in the Upper Paraguay River Basin. The Pantanal is a sedimentary basin, plain depressed characterized by undergoing annual floods. This study aims to compare two regions of the Pantanal Nhecolândia, eastern and south-west. Fieldwork was conducted to collect samples auger Dutch type, making the color description with the aid of Munsell table, texture and humidity. After was executed to granulometric analysis and preparing a histogram for examined size of the grains. As a result it that two areas are similar characteristics and but different along the profile the grains type, indicating the possible differences between two areas of the Pantanal Nhecolândia. Keywords: granulometric analysis, geomorphology, sedimentation. RESUMENEl Pantanal es un humedal conocido en el mundo, se encuentra en la Cuenca del Alto Paraguay. El Pantanal es una cuenca sedimentaria, deprimida y plana destacado principalmente por sometidos a inundaciones anuales. Este estudio tiene como objetivo comparar dos áreas del Pantanal Nhecolândia, Este y Suroeste. El trabajo de campo se llevó a cabo para recoger muestras de la barrena de tipo holandés, haciendo la descripción del color con la ayuda de la tabla de Munsell, la textura y la humedad. Después se le ocurrió a análisis granulométrico para evaluar los resultados obtenidos preparar un histograma para comprobar la cantidad y el tamaño de los granos. Como resultado, se observó que las áreas tienen características sutilmente similares, las diferencias en la cantidad del grosor de los granos a lo largo del perfil de la muestra, indicando de ese punto, las posibles diferencias entre dos áreas del Pantanal Nhecolândia. Palabras clave: análisis granulométrico; geomorfología; sedimentación.
Evolution stages of the spatial urban development
Authors: Stebletska Yu.
Published: December 2016

The factors influencing the change of urban space were considered. Key stages of urban geohistory were emphasized and in accordance with that the main historical types of cities were grouped. Each evolution stage of the spatial urban development was in detail analyzed. The main features, processes, and superior system of settlement for all historical types of cities were defined. Outstanding characteristics of all historical types of cities of all ages were determined and described. A table for features of historical types of cities on key indicators was designed. A decisive influence of economic systems on urban form and its social geography was defined. The influence of the transition of settlements from the early preindustrial economy to the classical industrial city through a capitalist economy, and later to modern approaches and trends in the so-called theory of “post-industrial” city through research of urban geohistory was traced. The way of decay of urban planning of preindustrial age from the rigidly regulated by the state, however well-ordered and well-thought-out planning on the basis of an orthogonal grid in ancient cities, to the spontaneous and disordered development in the Middle Ages, when the core of the city was the fortress and monastery, was studied. Typicality of the cities of the industrial age of the return from the uncontrolled growth, when the decisive role was played by differentiated rents for land in the early models of the industrial city, to the functional zoning in the age of modernism was defined. Urban planning in the post-industrial age in terms of the traditional city through the global processes of urbanization, which create new socio-spatial forms of settlements (metropolitan region, multicentered metropolitan regions) were described. The impact of globalization on the urban space and on creation of new forms of urban settlements was considered. Social and economic features that indicate the development of postmodern metropolis were considered.
History and person in short stories of Alexis Remizov The cycle «Poor fortune» Rational-irrational aspect of the writer’s fictional world
Authors: Sergeev O.V.
Published: December 2016

This article devoted to short stories, written by A.M. Remizov. Selected stories are united thematically. All of them depicted terror of history. Victim of that terror is an ordinary men. Famous historic persons represented as symptoms of tragic fate of Russia. This issue contains comparison of two different editions of his book of dreams «Bedovaja dolja» («Bad fate» and «Martyn Zadeka») on the background of different art’ periods, Silver age of Russian literature and émigré literature. As Russian artist Remizov used to feel his personal fate as a part of common fate of his main land, Rus-Russia. Because of it paradoxical forms of perceptions represented as different types of understanding complicated moments of individual life and existentional moments of human beings.
Linguistic and cultural interpretation metaphors from the N.S.Leskov's tale "Lefty"
Authors: Pavlishak T.A.
Published: December 2016

The article is devoted to consideration of metaphor from the perspective of cultural linguistics and cognitive science. It highlights selected metaphors from the N.S. Leskov's tale and discovers their didactic potential through disclosure of some characteristics of interpretation as a productive activity.
The influence of McKenzie’s method in the treatment of low back pain
Authors: Sousa Vanessa Paula de , Moura David Reis , Cunha Francisco Valmor Macedo da
Published: December 2016

Introduction: Low back pain, due to the high prevalence, is the main reason for sickness and pensions in Brazil causing a major burden for the state and the reduction of the individual’s quality of life. The treatment may be conservative (drug and therapy) or surgery, but often such treatments are not definitive and culminating in reincidivas. Among the physiotherapy intervention techniques, Mckenzie method stands out because it is an individualized intervention technique that emphasizes patient education through exercises to restore normal function, where the patient learns to avoid during treatment movements, postures and activities that worsen your condition. Objective: This study aimed to investigate the effect of Mckenzie method on the treatment of lumbar. Methods: We performed a literature search of articles published between 2005 to 2015, in Portuguese, English and French, using the key words low back pain, quality of life and physical therapy in Scienciedirect databases, Peter, Pubmed, LILACS and scielo. Results and conclusion: The articles were initially screened for the content of the titles and abstracts and confronted the inclusion and exclusion criteria. Subsequently, the selected articles were analyzed in all content and data were organized into figures and framework to present the main findings of the research. Publications on the theme revealed the importance of McKenzie in the reduction of pain symptoms and disability in low back pain, contributing to the patient’s return in their activities of daily living.
Evaluation of isometric strength in people with spinal cord injury: a review
Authors: Lima Jamile Ada Nascimento de , Oliveira Saulo Fernandes Melo de , Oliveira Lúcia Inês Guedes Leite de , Costa Manoel da Cunha
Published: December 2016

Introduction: isometric muscle strength in people with spinal cord injury is usually associated with locomotor activity, posture maintenance and activities of daily living. However, the variety of methods available for the evaluation hinders decision making on the part of the professionals involved. Objective: our objective was to review the literature of the area and determine the evaluation methods of isometric force and relationships with other components of health and physical fitness of people with spinal cord injury (SCI). Methods: consulted if the sites BIREME-Medline and SciELO, under the terms “spinal cord injury”, “paraplegia”, “tetraplegia”, “wheelchair athletes” and “disabilities athletes,” “isometric strength”, “handgrip” and “ handheld “with the help of the Boolean AND operator. Results: they were found 18 studies that met the inclusion criteria. The equipment available, the manual dynamometer is the most used. Sophisticated equipment can evaluate force components with increased functionality. There were no significant changes in hemodynamic variables during isometric strength tests. In conclusion, good isometric strength levels appear to correlate with increased functionality of people with SCI. Conclusion: however, they are lacking reference values related to the isometric strength for this population, especially when tested handgrip.
Physical Therapy at the postoperative of hip endoprosthesis for osteosarcoma: a case report
Authors: Venâncio Raysa Silva , Martins Tamiris Beppler , Santos Keyla Mara dos , Palandi Juliete , Sinhorim Larissa , Santos Gilmar Moraes
Published: December 2016

Introduction: Osteosarcoma is the most common malignancy among musculoskeletal tumors. It can be treated for preservation member or amputation. The cases treated for preservation member have improved functionality and quality of life, however, patients with oncologic diseases exhibit symptoms of anxiety and depression. Objective: The aim of this study is to describe the role of physiotherapy in the hip endoprosthesis after surgery for osteosarcoma of a patient treated at the Clinic Physiotherapy School of the University of the State of Santa Catarina (CEFID / UDESC) and verify their quality of life, functionality and symptoms of anxiety and depression. Methods: A descriptive study through case report. The subject was assessed before and after 10 sessions of physiotherapy on the quality of life, functionality and symptoms of anxiety and depression using a standardized assessment form, the Quality of Life Assessment Questionnaire (WHOQOL-BREF), the system Functional assessment (Musculoskeletal Tumor Society Rating Scale - MSTS); of Lower Limb Function Scale (EFMI) and the Hospital Anxiety and Depression Scale (Hospital Anxiety and Depression Scale - HADS); Results and Conclusions: Physical therapy treatment proposed to the patient allowed the increase of muscle strength; increased muscle tropism; improved member functionality (65% of EFMI); possible reduction of anxiety or depressive symptoms in HADS; presenting score (67.31%) of the WHOQOL-BREF and (56%) in MSTS. Thus, based on the functional, emotional and psychological outcomes, the proposed physical therapy had a positive influence on a patient’s quality of life osteosarcoma at the proximal end of the left femur, underwent resection and reconstruction member with endoprosthesis.
Use of the Box and Block Test for the evaluation of manual dexterity in individuals with central nervous system disorders: A systematic review
Authors: Oliveira Claudia Santos , Almeida Cibele Santos , Freitas Larissa Carolina , Santana Robéria , Fernandes Gislene , Junior Paulo Roberto Fonseca , Moura Renata Calhes Franco
Published: December 2016

Introduction: Therapies designed to improve the functional capacity of the upper limb have become a vast field of research. Current clinical methods for upper extremity evaluations address function, motor control, sensory deficiency, dexterity, muscle tone and range of motion. The quality and performance in relation to activities related to the work of daily living and recreational activities are largely determined by hand functions and manual dexterity. Abnormal dexterity and the loss of motor coordination are among the main adverse conditions stemming from neurological disorders. Objective: The aim of the present study was to perform a systematic review of the literature on the use of the Box and Block Test (BBT) for the evaluation of manual dexterity in patients with central nervous system disorders. Methods: Searches were performed the Medline, PEDro, Lilacs, Scielo and PubMed databases. The articles retrieved during the initial search were analyzed independently by two blinded reviewers based on the following inclusion criteria: (1) controlled clinical trial; (2) population with neurological disorders; (3) evaluation involving the BBT; (4) outcome: evaluation of manual dexterity; (5) year of publication: 2005 and 2016. Preselected articles were evaluated for methodological quality using the Physiotherapy Evidence Database (PEDro) scale (minimum score for inclusion: 5 points). Results: The search resulted in the retrieval of 51 articles, 42 of which did not meet the inclusion criteria. Nine articles addressed the use of the BBT as one of the methods for the evaluation of manual dexterity in patients with central nervous system disorders, were considered methodologically adequate and were included in the present systematic review. Conclusion: The studies analyzed suggest that the BBT is a fast, easy, safe measure of manual dexterity with good applicability for adults and children with neurofunctional diseases.
Сравнительный анализ налогообложения особых экономических зон в России и странах АТЭС
Authors: Пелькова Светлана Владимировна , Кольцова Татьяна Александровна , Хайруллина Нурсафа Гафуровна
Published: December 2016

В последние десятилетия особые экономические зоны получили широкое распространение на территории России. В связи с этим в статье рассматривается история, современное состояние и перспективы развития особых экономических зон в России и странах-участницах Форума АТЭС. Анализ истории создания свободных экономических зон показал, что попытки их создания в 1990-х гг. для нашей страны не увенчались успехом и не оправдали ожиданий, поскольку цели и задачи, которые были поставлены при образовании этих зон, не были достигнуты.

Анализируются особенности налогообложения налогом на прибыль и налогом на имущество организаций, транспортным налогом, земельным налогом, страховыми взносами во внебюджетные фонды, налогом на добавленную стоимость резидентов особых экономических зон РФ в зависимости от их типа. Проводится оценка налоговых льгот и налоговых преференций по отдельным видам налогов для особых экономических зон РФ и стран-участниц АТЭС. Выявляются основные проблемы налогообложения особых экономических зон РФ и возможные пути их решения с учетом опыта стран-участниц АТЭС.

Формулируется вывод о том, что функционирование особых экономических зон в РФ на сегодняшний день не доведено до идеала и причиной тому являются как сложная экономическая и политическая ситуация на национальном и международном рынках, так и несовершенство управления особыми экономическими зонами как на местах, так и на законодательном уровне. Принятие ряда мер, направленных на стабилизацию развития ОЭЗ, а также ужесточение контроля за их исполнением помогут вывести регионы на новый уровень. В результате они смогут достичь поставленных Правительством РФ целей по улучшению инвестиционной привлекательности регионов и созданию необходимой среды для успешного ведения бизнеса на территориях ОЭЗ, что окажет непосредственное влияние на экономическое положение всей страны.
Развитие человека: энциклопедический взгляд
Authors: Луков Валерий Андреевич , Луков Сергей Валерьевич
Published: December 2016

Энциклопедическая статья о социальном развитии человека — одном из главных терминов социологии молодежи. Развитие молодежи идет по тем же направлениям, что и развитие человека, что и обосновывается в статье. 
Cidadania Sexual: Postulado Interpretativo da Igualdade / Sexual Citizenship: An Interpretive Principle of Equality
Authors: Moreira Adilson José
Published: December 2016

Resumo: Este artigo desenvolve uma sistematização do conceito de cidadania sexual presente na jurisprudência brasileira sobre uniões entre pessoas do mesmo sexo. Este princípio tem sido utilizado por nossos tribunais como um parâmetro substantivo de controle de constitucionalidade, mas nunca recebeu uma formulação adequada. A ausência de uma definição clara desse postulado normativo cuja importância transcende a discussão sobre o acesso a direitos matrimoniais justifica o presente esforço intelectual. Pensamos que ele pode operar como um contraponto à atual mobilização política contrária ao tratamento igualitário de minorias sexuais, movimento que procura reverter as conquistas alcançadas por esses grupos nas últimas décadas. Este trabalho examina a noção de cidadania sexual a partir de desenvolvimentos teóricos na área de direito constitucional e da ciência política, bem como na jurisprudência de tribunais nacionais e estrangeiros sobre direitos de minorias sexuais. Mais do que um simples recurso retórico, o conceito sob análise identifica uma forma de pertencimento bastante relevante nas sociedades contemporâneas, mas cuja significação é obscurecida em função da compreensão da cidadania como um mero status jurídico e político.Palavras-chave: Cidadania; Sexualidade; Identidade; Igualdade. Abstract: This article provides an overview of the concept of sexual citizenship present in many Brazilian court decisions about same-sex unions. This principle has been used by our courts as a substantive parameter of judicial review, but has not yet received an adequate formulation. The absence of a clear definition of this normative parameter justifies this intellectual endeavor because its relevance transcends the discussions about access to spousal rights. We think that it can operate as a counterpoint to the current political mobilization around the legal status of sexual minorities, a movement that seeks to reverse important political victories in recent decades. This paper examines the notion of sexual citizenship based on theoretical developments in the fields of constitutional law and political science as well as in national and international court decisions about sexual minority rights. Although its significance remains concealed because of the understanding of citizenship as a mere legal and political status, this concept identifies a very relevant way of belonging in contemporary societies.Keywords: Citizenship; Sexuality; Identity; Equality.