bluuebunny/crossref_metadata_2025 huggingface dataset:
Proteomic analysis of Malaysian Horseshoe crab (Tachypleus gigas) hemocytes gives insights into its innate immunity host defence system and other biological processes
Authors: Adebayo Ismail Abiola , Habib Mohd Afiq Hazlami , Sarmiento Maria E. , Acosta Armando , Yaacob Nik Soriani , Ismail Mohd Nazri
Published: August 2022

Horseshoe crabs are one of the most studied invertebrates due to their remarkable innate immunity mechanism and biological processes. In this work, the proteins of the lipopolysaccharides (LPS)-stimulated and non-stimulated hemocytes of Malaysian Tachypleus gigas were profiled using LC-MS/MS. A total of 154 proteins were identified in both types of samples. Additionally, seventy-seven proteins were commonly found in both conditions, while 52 and 25 proteins were uniquely found in the LPS-stimulated and non-stimulated hemocytes, respectively. ATP-dependent energy-generating proteins such as actins and BLTX actin-related proteins were detected in both stimulated and non-stimulated T. gigas hemocytes, but more of such proteins were found in the former type. Proteins such as tachylectin-2, coagulogen, c-reactive proteins, histones, hemocyanin, and DNA polymerase, which play key roles in the organism’s innate immunity, were differentially expressed in the hemocytes following LPS challenge. In conclusion, the proteins identified in the hemolymph of T. gigas are vital for the organism’s molecular functions, biological processes, and activation of innate immunity.
Chromosomal painting in Charadrius collaris Vieillot, 1818 and Vanellus chilensis Molina, 1782 and an analysis of chromosomal signatures in Charadriiformes
Authors: Pinheiro Melquizedec Luiz Silva , Nagamachi Cleusa Yoshiko , Ribas Talita Fernanda Augusto , Diniz Cristovam Guerreiro , O´Brien Patricia Caroline Mary , Ferguson-Smith Malcolm Andrew , Yang Fengtang , Pieczarka Julio Cesar
Published: August 2022

Charadriiformes represent one of the largest orders of birds; members of this order are diverse in morphology, behavior and reproduction, making them an excellent model for studying evolution. It is accepted that the avian putative ancestral karyotype, with 2n = 80, remains conserved for about 100 million years. So far, only a few species of Charadriiformes have been studied using molecular cytogenetics. Here, we performed chromosome painting on metphase chromosomes of two species of Charadriidae, Charadrius collaris and Vanellus chilensis, with whole chromosome paint probes from Burhinus oedicnemus. Charadrius collaris has a diploid number of 76, with both sex chromosomes being submetacentric. In V. chilensi a diploid number of 78 was identified, and the Z chromosome is submetacentric. Chromosome painting suggests that chromosome conservation is a characteristic common to the family Charadriidae. The results allowed a comparative analysis between the three suborders of Charadriiformes and the order Gruiformes using chromosome rearrangements to understand phylogenetic relationships between species and karyotypic evolution. However, the comparative analysis between the Charadriiformes suborders so far has not revealed any shared rearrangements, indicating that each suborder follows an independent evolutionary path, as previously proposed. Likewise, although the orders Charadriiformes and Gruiformes are placed on sister branches, they do not share any signature chromosomal rearrangements.
Antibiofilm activity of silver nanoparticles biosynthesized using viticultural waste
Authors: Miškovská Anna , Rabochová Michaela , Michailidu Jana , Masák Jan , Čejková Alena , Lorinčík Jan , Maťátková Olga
Published: August 2022

Green methods have become vital for sustainable development of the scientific and commercial sphere; however, they can bring new challenges, including the need for detailed characterization and elucidation of efficacy of their products. In this study, green method of silver nanoparticles (AgNPs) production was employed using an extract from grapevine canes. The aim of the study was to contribute to the knowledge about biosynthesized AgNPs by focusing on elucidation of their antifungal efficiency based on their size and/or hypothesized synergy with bioactive substances from Vitis vinifera cane extract. The antifungal activity of AgNPs capped and stabilized with bioactive compounds was tested against the opportunistic pathogenic yeast Candida albicans. Two dispersions of nanoparticles with different morphology (characterized by SEM-in-STEM, DLS, UV-Vis, XRD, and AAS) were prepared by modification of reaction conditions suitable for economical production and their long-term stability monitored for six months was confirmed. The aims of the study included the comparison of the antifungal effect against suspension cells and biofilm of small monodisperse AgNPs with narrow size distribution and large polydisperse AgNPs. The hypothesis of synergistic interaction of biologically active molecules from V. vinifera extracts and AgNPs against both cell forms were tested. The interactions of all AgNPs dispersions with the cell surface and changes in cell morphology were imaged using SEM. All variants of AgNPs dispersions were found to be active against suspension and biofilm cells of C. albicans; nevertheless, surprisingly, larger polydisperse AgNPs were found to be more effective. Synergistic action of nanoparticles with biologically active extract compounds was proven for biofilm cells (MBIC80 20 mg/L of polydisperse AgNPs in extract), while isolated nanoparticles suspended in water were more active against suspension cells (MIC 20 mg/L of polydisperse AgNPs dispersed in water). Our results bring new insight into the economical production of AgNPs with defined characteristics, which were proven to target a specific mode of growth of significant pathogen C. albicans.
Development and validation of a nomogram for the prediction of late culture conversion among multi-drug resistant tuberculosis patients in North West Ethiopia: An application of prediction modelling
Authors: Anley Denekew Tenaw , Akalu Temesgen Yihunie , Merid Mehari Woldemariam , Dessie Anteneh Mengist , Zemene Melkamu Aderajew , Demissie Biruk , Arage Getachew
Published: August 2022

Introduction

Multi-drug resistant tuberculosis has impeded tuberculosis prevention and control due to its low treatment efficiency and prolonged infectious periods. Early culture conversion status has long been used as a predictor of good treatment outcomes and an important infection control metric, as culture-negative patients are less likely to spread tuberculosis. There is also evidence that suggests that delayed sputum conversion is linked to negative outcomes. Therefore, this study was aimed at developing a nomogram to predict the risk of late culture conversion in patients with multi-drug resistant tuberculosis using readily available predictors.

Objective

The objective of this study was to develop and validate a risk prediction nomogram for the prediction of late culture conversion among multi-drug resistant tuberculosis patients in North-West Ethiopia.

Methods

Multi-drug resistant tuberculosis data from the University of Gondar and the Debre Markos referral hospitals have been used and a total of 316 patients were involved. The analysis was carried out using STATA version 16 and R version 4.0.5 statistical software. Based on the binomial logistic regression model, a validated simplified risk prediction model (nomogram) was built, and its performance was evaluated by assessing its discriminatory power and calibration. Finally, decision curve analysis (DCA) was used to assess the generated model’s clinical and public health impact.

Results

Registration group, HIV co-infection, baseline BMI, baseline sputum smear grade, and radiological abnormalities were prognostic determinants used in the construction of the nomogram. The model has a discriminating power of 0.725 (95% CI: 0.669, 0.781) and a P-value of 0.665 in the calibration test. It was internally validated using the bootstrapping method, and it was found to perform similarly to the model developed on the entire dataset. The decision curve analysis revealed that the model has better clinical and public health impact than other strategies specified.

Conclusion

The developed nomogram, which has a satisfactory level of accuracy and good calibration, can be utilized to predict late culture conversion in MDR-TB patients. The model has been found to be useful in clinical practice and is clinically interpretable.
Sketching hope and grief in transition: Situating anticipation in lived futures
Authors: Lindström Kristina , Jönsson Li , Hillgren Per-Anders
Published: August 2022

In light of current environmental challenges, it often seems that optimism is a required emotional state for addressing our future. This can be seen in how different technological fixes are assumed to sort our futures out at the same time as requiring minimal change in our daily lives. Moving beyond our existing high-carbon and material lives requires not only that we deal with the optimistic end of the spectrum but also that we envision fragile and uncertain futures. In response, this article proposes a designerly format for supporting public anticipation that attends to and cares for tensions between hope and grief, with the aim of nurturing grounds for living with uncertain futures. In contrast to abstract and decontextualized visions and images of the future that can be hard to relate to, the format situates anticipation in lived futures, that are ongoing, emerging and situated in specific locations, environments and experiences. By tending to anticipated losses related to the transition to a post-carbon future, the workshop format created space for confronting shared difficulties and vulnerabilities. Despite the lack of easy solution, the format also opened up for articulating alternatives and less tech-oriented hopeful engagements and practices.
Creating the Conceptual and Logical Model of a Journal Database
Authors: Hampel György
Published: August 2022

This article describes the process of creating the conceptual and logical model of a journal database. To efficiently extract the information from the articles published in the journal so far, the idea of creating a database has emerged. To create a database, it is recommended to design a high-level conceptual model and convert that into a logical data model. The benefit of the thoughtful design is that it shows the structure of the database in an easily comprehensible form. The entity-relationship model is a fast and efficient way to create the conceptual model and it can be easily converted to a relational database model, which is a logical model. The initial version of the entity-relationship model of the journal database had one entity type, 25 attributes, and no relationship. The final version contained three entity types, 39 attributes, and three relationships. This final conceptual model was converted to a logical model, the relational model. The result was ten tables to store entity data with 22 different fields and another three tables to ensure the relationships between the tables. The developed model can be created in a relational database manager and is suitable for serving information needs related to the journal.
The protective effects of dietary polyphenols on Alzheimer's disease
Authors: Urganci Ünkan , Işık Fatma
Published: August 2022

Alzheimer's disease (AD) is a progressive irreversible neurodegenerative disease in the hippocampus and cortex regions of the brain and is the most common cause of dementia in the elderly population among 40 million cases worldwide today, it is thought that this number will exceed up to 100 million by 2050. The disease is characterized by symptoms of memory loss, difficulty in speaking, decision making, learning, problem solving, and impaired perception of time and orientation. In its pathogenesis, the amyloid beta (Aβ) senile plaques accumulation in the extracellular synaptic spaces of the neurocortex, the formation of intracellular hyperphosphorylated tau protein deposition and neurofibrillary tangles (NFY) are important and triggered neurodegeneration mainly affects cognitive behavior and memory. Phenolic compounds are organic compounds containing a benzene ring to which one or more hydroxyl groups are attached. Studies have shown that regular consumption of polyphenols reduces the risk of developing neurodegenerative diseases. Studies have reported that polyphenols inhibit Aβ production and accumulation processes by interacting with different forms of amyloid structure. In this study, polyphenols and their therapeutic properties against AD will be discussed extensively.
A new approach for imperfect boundary conditions on the dynamic behavior
Authors: Praisach Zeno-Iosif , Adeljan Dorel , Pîrșan Dan Alexander , Gillich Gilbert-Rainer
Published: August 2022

Real beams have non-ideal boundary conditions and it is necessary to use new models to determine the real modal parameters. Models that use ideal conditions do not fully reflect reality and can lead to unsatisfactory description of the dynamic behavior. The hinged – hinged boundary conditions, which is in the focus of the paper, are not analyzed as a single beam, but as a continuous beam with three spans, free at the ends. The continuous beam with three spans is analyzed for cases in which the intermediate supports can occupy any position along the length of the beam, by an analytical solution of the problem, with the example of cases when the intermediate supports are located very close at the free ends of the continuous beam, thus simulating the real case for an hinged beam at both ends; the situation in which the intermediate supports are very close to one of the ends of the beam, thus simulating the real case of the clamped beam, with an imperfect clamped end; and the situation in which the intermediate supports are very close located anywhere on the beam length, thus simulating the hypothetic case with a continuous beam free at the ends and fix on the hinged supports. The analytic results are compared with numerical results by using finite elements method.
A mobile fixture system for friction stir welding application
Authors: Rasheed Akeem Abiodun , Ogedengbe Tunde Isaac , Abioye Taiwo Ebenezer
Published: August 2022

In an attempt to provide a more flexible means of achieving friction stir welding (FSW) of Aluminum without the use of expensive FSW machine tool, which are not readily available, this study developed a mobile fixture system (MFS) for FSW on Vertical milling Machine Tool (VMMT) and Pillar drilling machine Tool (PDMT). A conceptual design of the fixture system with a moving work table, which provides for transverse feed (movement) of the workpieces during FSW, was generated.  The detailed design of the components of the MFS was done using existing mechanical design formulae. Subsequently, the design was fabricated and evaluated. An ATmega 328P Arduino Uno microcontroller was used to design a control system to automate the MFS worktable movement. Results revealed that the MFS worked smoothly during FSW of AA 1100 materials. The MFS performed well during the FSW of the Aluminum materials on the VMMT as well as the PDMT. The efficiency of its motion accuracy was estimated as 87.2%. Also, the trend of the tensile strength and the hardness value as well as the joint efficiencies of the AA 1100 weldments produced using the developed MFS agreed with existing studies.
Hyperparathyroidism and Vitamin D: Relationship Difficulties
Authors: Suplotova L. A. , Avdeeva V. A. , Sudnitsyna A. S. , Rozhinskaya L. Y.
Published: August 2022

Hyperparathyroidism is a clinical and laboratory syndrome characterized by hyperproduction of parathyroid hormone (PTH) by cells of the parathyroid glands (PTG) and is subdivided, depending on the cause of its occurrence, into primary (PHPT), secondary (SHPT) and tertiary hyperparathyroidism (THPT). To date, only a few scientific papers have been published on the features of the relationship between vitamin D and various forms of hyperparathyroidism, there may be several reasons for this. First, this is due to the fact that the true prevalence of vitamin D deficiency in hyperparathyroidism is unknown. Secondly, difficulties in the differential diagnosis of hyperparathyroidism sometimes entail not always justified surgical intervention with the potential development of complications, which, of course, is a rather narrow area of interest, both in endocrinology in particular and in medicine in general. Thirdly, the asymptomatic, often hidden, latent nature of the variety of multiple organ clinical manifestations of hyperparathyroidism, in combination with low levels of 25(OH)D, as the disease progresses, can lead to a significant decrease in the quality and life expectancy of patients. The combination of these arguments prompted us to summarize all the data available to date on the complexity of the relationship between vitamin D and various forms of hyperparathyroidism.
The effectiveness of screening to identify patients with osteoporosis/high risk of fractures in primary health care
Authors: Gladkova E. N. , Tanaev V. G. , Lesnyak O. M. , Zabezhinskaya I. V. , Iluysin Yu. M. , Kolbin M. Yu.
Published: August 2022

Background. The organization of screening for osteoporosis is an actual problem due to the need for early detection of patients with high risk of fractures and initiation of their treatment.

Aim. The aim of our study was to study the effectiveness of screening for osteoporosis (high risk of fractures) in postmenopausal men and women 40 years and older.

Materials and methods. Screening was performed by outpatient doctors for all people aged 40 years and older who applied for various reasons. The doctor asked standard questions included in the FRAX questionnaire.

Results. In 2017– 2020, 11,013 people were screened by outpatient doctors — 31.7% of the total attached population aged 40 years and older. According to the screening results, 21.9% people were identified with a high risk of fractures. The average 10-year probability of major osteoporotic fractures in these patients (19.0±7.9%) was statistically significantly higher compared to the rest of the screened (7.6±3.3%), p=0.0001. 60% (1,450 people) of the group of individuals with an identified high risk of fractures were patients with FRAX in the area of therapeutic intervention. Among them were patients with indications of a fracture and without a history of fractures. In the remaining 40%, the high risk was determined only on the basis of the fact of a previously suffered fracture (their FRAX index was below the intervention threshold). In general, using only the FRAX calculator, 40 men and 1410 women were identified as having a high risk of fractures, which accounted for 1.3% of the male and 17.7% of  the female screened population, respectively. With the simultaneous use of FRAX and anamnestic data on a previous fracture, 13.3% of men and 25.3% of women in the screening population had a high risk of fractures.

Conclusion. Screening in primary health care has allowed us to identify 21.9% of the screened population of men and women aged 40 years and older (postmenopausal women) as having a high risk of fractures. Screening with simultaneous calculation of the 10-year risk of fractures according to FRAX and clarification of the presence of a history of fractures was the most effective.
Investigating the antecedents and outcomes of work-life balance: evidence from garment industries in Indonesia
Authors: Wahyuni Sari , Rahmasari Dian
Published: August 2022

The garment industry is one of the main contributors to Indonesia's GDP. However, work-life balance has become a crucial issue for workers in this industry. This study aims to investigate the antecedents and outcomes of work-life balance among workers in the garment industry. More specifically, we examine the effect of asset ownership and working conditions (health conditions, compensation, and working hours) affect work-life balance. Furthermore, we also examine the effect of work-life balance on job satisfaction, life satisfaction, and turnover intention. We collected data using a survey of 3691 garment workers in Central Java, West Java, DI Yogyakarta, DKI Jakarta, and Banten. The analysis shows that work-life balance could increase workers' life satisfaction and job satisfaction. Interestingly, health condition is found out to be the important variable that could   improve work-life balance significantly.
The dark side of perceived corruption: Mediating mechanism between love of money and evil behavior
Authors: Maksum Ikhsan , Ningtyas Mega Noerman
Published: August 2022

Many studies about unethical behavior (evil behavior) in the workplace have underlying various research related to love of money and perception of corruption as in this research. One of the main ideas that emerged is “The love of money is a root of all kinds of evil” Timothy, 6:10. In most studies, there is a gap and lack of prior research involving the mechanism of indirect effect between the love of money behavior and unethical behavior in public sector institutions. In this research, we focus on the role of mediation between the perception of corruption and love of money toward unethical behavior. The researcher spread the questionnaire for obtained 149 respondents who are an employee from the public sector institution. Meanwhile, the research method that we use is a quantitative study, which allows for doing the study with a fast time and broad generalizability. We find that perception of corruption could partially mediate the effect between the love of money and unethical behavior in public sector employees. This study proves that employees who work in public sector institutions have a corruption perception that can trigger evil behavior.  employees who have a strong orientation towards money are more likely to try to earn more money to enrich themselves, and then employees engage in unethical behavior.
Tributación y dinámica económica regional en Colombia
Authors: Mendoza Tolosa Henry Antonio , Campo Robledo Jacobo , Clavijo Cortez Pedro Hugo
Published: August 2022

Este artículo constituye una reflexión en diferentes contextos acerca del impacto que tienen los impuestos  departamentales y municipales en el crecimiento económico de las regiones. Para ello, aborda la descripción de las particularidades de la estructura y dinámica de los impuestos territoriales en Colombia en cada uno de sus ámbitos específicos de aplicación, al igual que el desempeño de la actividad económica desde las cuentas nacionales departamentales cubriendo el periodo 2005-2018. Al lado de la lectura de los indicadores significativos de dicho comportamiento, se adelanta el estudio de los términos per cápita del Producto Interno Bruto y la tributación de las entidades territoriales, así como la exploración de un modelo estadístico que identifique en contexto la naturaleza y magnitud de la causalidad que los tributos regionales tienen en el comportamiento de la economía para el periodo elegido. Los resultados muestran que a pesar de tener una estructura tributaria anquilosada, compleja, desactualizada, sin un marco legal que se ajuste de manera flexible a las particularidades y potencialidades económicas de cada región, los impuestos departamentales y municipales tienen un efecto progresivoen el crecimiento económico.
Efectos de la comunicación del banco central sobre el desacuerdo en las expectativas de la tasa de política monetaria: evidencias para Colombia
Authors: Galvis Ciro Juan Camilo , Anzoátegui Zapata Juan Camilo
Published: August 2022

El objetivo de este trabajo es investigar los efectos de la comunicación del banco central en la formación del pronóstico de la tasa de interés de política monetaria. Para ello, es utilizado como estudio de caso la economía colombiana para el período 2014-2020. La metodología empleada consiste en evaluar los efectos de la información suministrada en las minutas, el volumen de noticas y las publicaciones del banco central sobre los desacuerdos en las expectativas del mercado financiero con respecto a los movimientos futuros de la tasa de interés. Por medio de regresiones econométricas, se encuentra que las decisiones de política que se realizan en consenso, así como los mayores esfuerzos en la redacción de las minutas, tienen la capacidad de reducir la incertidumbre entre los agentes. En consecuencia, la principal recomendación de política apunta a que el Banco Central de Colombia debería realizar mayores esfuerzos en la redacción de las minutas y explicar de forma más detallada las discrepancias entre los directores.
Why policy makers and social scientists should be adopting behavioral economics? An analysis for the period 2000-2020.
Authors: Aliende Iñaki , Escot Lorenzo
Published: August 2022

This paper presents three analysis concerning the relevance of Behavioral Economics (BE). First, to evaluate its academic relevance, we analyze the impact of BE contributions in some of the main scientific databases. Second, to recognize the level of implementation, we analyze the reports published by international organizations and the so-called Behavioral Insight Units (nudge units). And third, to validate BE as a distinctive approach, we compare eight recognized scientific papers. As conclusion, although there is a remarkable consolidation of BE as academic discipline, the applied reach of BE is still limited since only seven countries show its comprehensive implementation.
Are Stay-at-Home and Face Mask Orders Effective in Slowing Down COVID-19 Transmission? – A Statistical Study of U.S. Case Counts in 2020
Authors: Wang Ping , Le Huy
Published: August 2022

Whether the stay-at-home order and face mask mandate are effective in slowing down the COVID-19 virus transmission is up for debate. To investigate this matter, we employ a unique angle. A two-wave logistic equation is proposed and then fitted to the cumulative case counts of all 50 states in the U.S. from the onset to early December of 2020 when vaccinating begins at large scale. The data period is confined to isolate the effects of executive orders from that of vaccination. The length of the first wave’s accelerating phase is regressed on variables describing the stay-at-home order and face mask mandate, along with control variables. A state’s lockdown duration is discovered to be negatively related to the time it takes for the virus to transit from accelerating to decelerating rates. This finding provides statistical support to the executive orders and can be useful in guiding risk management of future pandemics.
The entire chloroplast genome sequence of Asparagus cochinchinensis and genetic comparison to Asparagus species
Authors: Sheng Wentao
Published: August 2022

Asparagus cochinchinensis is a traditional Chinese medicinal plant. The chloroplast (cp) genome study on A. cochinchinensis is poorly understood. In this research, we collected the data from the cp genome assembly and gene annotation of A. cochinchinensis, followed by further comparative analysis with six species in the genus Asparagus. The cp genome of A. cochinchinensis showed a circular quadripartite structure in the size of 157,095 bp, comprising a large single-copy (LSC), a small single-copy (SSC), and two inverted repeat (IR) regions. A total of 137 genes were annotated, consisting of 86 protein-coding genes, 8 ribosomal RNAs, 38 transfer RNAs, and 5 pseudo-genes. Forty scattered repetitive sequences and 247 simple sequence repeats loci were marked out. In addition, A/T-ending codons were shown to have a basis in the codon analysis. A cp genome comparative analysis revealed that a similar gene composition was detected in the IR and LSC/SSC regions with Asparagus species. Based on the complete cp genome sequence in Asparagaceae, the result showed that A. cochinchinensis was closely related to A. racemosus by phylogenetic analysis. Therefore, our study providing A. cochinchinensis genomic resources could effectively contribute to the phylogenetic analysis and molecular identification of the genus Asparagus.
Pseudohypoaldosteronism associated with hypertrophic cardiomyopathy, hypertension and thrombocytosis due to mutation in the ELAC2 gene: a case report
Authors: Mendes Luana Carvalho , de Oliveira Magalhães Rafael , Pereira dos Santos Rodrigo Kelson , Araújo Rogério Santiago
Published: August 2022

Objectives

PHA1 is a rare heterogeneous disorder featured by changes in renal electrolyte transport due to mineralocorticoid resistance. The aim of the current study is to report the case of a child with 5-year follow-up presenting mutation in the ElaC Ribonuclease Z 2 (ELAC2) gene and clinical-laboratory diagnosis of pseudohypoaldosteronism type 1 (PHA1), as well as atypical clinical manifestations such as thrombocytosis, borderline aldosterone levels, and plasma renin activity.

Case presentation

The patient was treated with corticosteroids and salt replenishment. His cardiological condition presented gradual regression and the introduction of new food items in his diet dismissed the need of salt replenishment.

Conclusions

This new molecular mechanism should be taken into consideration in differential diagnoses in children with hyperkalemia, hyponatremia, delayed growth, hypertension and hypertrophic cardiomegaly.
Maternal urogenital infection and fetal heart functional assessment – what is the missing link?
Authors: Murlewska Julia , Sylwestrzak Oskar , Strzelecka Iwona , Respondek-Liberska Maria
Published: August 2022

Objectives

Maternal urogenital infections during pregnancy are worldwide frequent problem. The aim was to analyze influence of maternal genitourinary infection on fetal cardiac function, pregnancy development and obstetrical outcomes.

Methods

This was a single-center cohort study on fetuses (average at 28th week) in two groups: with maternal urogenital infections (study group n=49) and control group with no infections (n=59). Parvovirus B19, toxoplasmosis, cytomegalovirus, herpes simplex infections, congenital malformations, fetal growth restriction, chronic maternal diseases, as well as patients with body mass index (BMI) >25 kg/m2 were excluded. We analyzed: maternal age, time of delivery, neonatal birth weight, Apgar scores, average time of hospitalization of newborns after birth and several fetal echocardiographic parameters.

Results

The only statistical differences was found for shorter isovolumetric relaxation time (IRT) (40 ± 10 vs. 45 ± 9; p=0.03) and longer ejection time (ET) [ms] for right ventricle (RV) (176 ± 24 vs. 164 ± 18; p=0.01). Thick placenta was observed more frequent in study group than in controls (36.7 vs. 16.9%; p= 0.02).

Conclusions

The missing link for explanation of these findings was coincidence with thick placenta. This is probably the first observation suggesting that thick placenta (>5 cm) may affect fetal RV function in normal heart anatomy: prolongation of right ventricular ET and shortening of fetal right ventricular IVRT.
Retrospective review of GCT cutoff value based on pre-pregnancy BMI class in patients with GDM
Authors: Angras Kajal , Boyd Victoria , Young Amanda J. , Dhanya Mackeen Awathif
Published: August 2022

Objectives

To determine the optimal glucose challenge test (GCT) cutoff value for the screening of gestational diabetes mellitus (GDM) based on pre-pregnancy BMI.

Methods

An-IRB approved retrospective cohort analysis of singleton pregnancies at a large tertiary healthcare center from January 2004 to December 2020 was performed. The first GCT value completed between 20 and 32 weeks was used. Using a receiver operator curve (ROC), we sought to determine the optimal GCT cutoff value for each BMI category that would predict the development of GDM. Youden Index was used to determine optimal cut-point of GCT values for each BMI class.

Results

A total of 23,550 patients with a GCT value were identified. Of those, 1,676 (7.1%) were diagnosed with GDM. 513 (30.6%) with normal BMI, 449 (26.8%) overweight, 347 (20.7%) class I obese, 210 (12.5%) class II obese, and 157 (9.4%) class III obese patients were diagnosed with GDM. Gestational diabetes was predicted at GCT cutoff value of 130 mg/dL with an area under the curve (AUC) of 0.92 (BMI <25), 131 mg/dL with an AUC of 0.92 (overweight BMI), 131 mg/dL with an AUC of 0.89 (class I BMI), 133 mg/dL with an AUC of 0.88 (class II BMI), and 131 mg/dL with an AUC of 0.88 (class III BMI).

Conclusions

AUC ranged from 0.88 to 0.92 with 93% or greater sensitivity for GCT cutoff value across each of the BMI categories. The findings support a GCT cutoff value of 130 mg/dL for GDM screening regardless of BMI.
Partial actions on convergence spaces
Authors: Adu Nathaniel , Mikusiński Piotr , Richardson Gary
Published: August 2022

Continuous partial actions and continuous enveloping actions are investigated in the category of convergence spaces. Product and quotient constructions are considered. Further, it is shown that a continuous partial action on a convergence space can be extended to a continuous partial action on a compactification of the convergence space.
Optical rectification and thermal currents in optical tunneling gap antennas
Authors: Mennemanteuil Marie Maxime , Buret Mickaël , Colas-des-Francs Gérard , Bouhelier Alexandre
Published: August 2022

Electrically-contacted optical gap antennas are nanoscale interface devices enabling the transduction between photons and electrons. This new generation of device, usually constituted of metal elements (e.g. gold), captures visible to near infrared electromagnetic radiation and rectifies the incident energy in a direct-current (DC) electrical signal. However, light absorption by the metal may lead to additional thermal effects which need to be taken into account to understand the complete photo-response of the devices. The purpose of this communication is to discriminate the contribution of laser-induced thermo-electric effects in the photo-assisted electronic transport. We show case our analysis with the help of electromigrated devices.
Fractional simulations for thermal flow of hybrid nanofluid with aluminum oxide and titanium oxide nanoparticles with water and blood base fluids
Authors: Khan Muhammad Ijaz , Mansir Ibrahim B. , Raza Ali , Khan Sami Ullah , Elattar Samia , Said Hanaa Mohamed , Tlili Iskander , Alharbi Khalid Abdulkhaliq M. , Galal Ahmed M.
Published: August 2022

The fractional model has been developed for the thermal flow of hybrid nanofluid due to the inclined surface. The thermal investigation of the hybrid nanomaterial is predicted by utilizing the molybdenum disulphide nanoparticles and graphene oxide nanomaterials. The flow computations for mixed convection flow of nanoparticles and base fluids are performed due to vertical oscillating plate. The simulations for the formulated model have been done ρ-Laplace transform technique for Caputo fractional simulations. Definitions of Mittage–Leffler function and ρ-Laplace transform are also presented for the governing model. The application of updated definitions of ρ-Laplace transform for the Caputo fractional model is quite interesting unlike traditional Laplace transforms. The comparative investigation for both types of nanoparticles is performed for heat and mass transfer rates. It is observed that the heat enhancement rate due to water-based nanoparticles is relatively impressive compared to the kerosene oil-based nanomaterials.
Long Subject Questions in French: An Insight into the Left Periphery of Selected CPs
Authors: Berthelot Frédérique
Published: August 2022

This article presents experimental data assessing the acceptability status of long subject questions (LSQs) in French. It shows that their suboptimal score does not reflect dialect variation and it fails to detect a change in progress. An analysis, developing further the rescuing strategy proposed in Rizzi and Shlonsky's freezing account, is presented. The crux of the proposal is that a Case mismatch obtains within the embedded complementizer, which is shown to be necessarily syncretic in LSQs. The full acceptability of embedded subject questions is then discussed and accounted for within this framework.
Normen beim kooperativen Schreiben im naturwissenschaftlichen Unterricht – eine empirische Rekonstruktion
Authors: Bleiker Johanna
Published: August 2022

Writing in science education is considered to have great potential for language and science learning. However, the ways in which teachers and their students interact as writing communities in science lessons has so far rarely been studied in depth, particularly regarding thenormswhich guide cooperative writing. The present article remedies this by presenting the results of a study on the writing norms observable in cooperative writing tasks in science lessons in Swiss primary schools (3rd, 4th and 5th grade). A video corpus of appr. 50 hours was analysed using a combination of approaches, namely Qualitative Content Analysis and Conversation Analysis. First, the concept of norms underlying the present study is discussed and then, the methodological procedure, the data and results are presented. The writing norms reconstructed on the basis of the corpus represent six areas: 1. the way writing tasks are dealt with in science lessons, 2. content, 3. wording, 4. accuracy (orthography, morphology, syntax), 5. visual appearance (handwriting, layout) and 6. the procedure of cooperative writing itself. The article provides an overview of the reconstructed norms as well as a more detailed discussion of selected norms illustrated by corpus examples.
Aufstieg, Fall oder Wandel der Erlebnisorientierung? Eine Positionsbestimmung nach 30 Jahren „Erlebnisgesellschaft“
Authors: Delhey Jan , Schneickert Christian
Published: August 2022

Vor dreißig Jahren veröffentlichte Gerhard Schulze die Theorie der Erlebnisgesellschaft, der zufolge die Menschen in wohlhabenden Ländern zunehmend nach Erlebnissen streben, um ihr Projekt des schönen Lebens zu gestalten. Angesichts neuerer Gegenwartsdiagnosen, die insgesamt ein sehr krisenhaftes Bild der Spätmoderne zeichnen, erscheint diese Idee heute eigentümlich aus der Zeit gefallen. Vor diesem Hintergrund erörtern wir in diesem Beitrag zwei Fragen. Die erste, vor allem auf die zurückliegenden Jahre gerichtete Frage ist, ob der Erlebnisgesellschaft mit ihrer starken Innenorientierung tatsächlich nur eine kurze Blütezeit beschieden war und inzwischen die Außenorientierung der kompetitiven Gesellschaft wieder an Bedeutung gewonnen hat – oder ob sich die Erlebnisgesellschaft, gewissermaßen unter dem Radar des aktuellen Krisendiskurses, doch weiter entfaltet hat. Mit Daten des European Social Survey 2002–2018 für Deutschland zeigen wir, dass die Erlebnisorientierung in den letzten zwei Jahrzehnten auf hohem Niveau noch einmal zugenommen hat, während die Statusorientierung vorübergehend angestiegen war, um dann in den 2010er Jahren spürbar zurück zu gehen. Die zweite, stärker auf die kommenden Jahre gerichtete Frage ist, welche neuen existenziellen Problemdefinitionen jenseits des erfolgreichen und des schönen Lebens, die beide einer Steigerungslogik folgen, sich abzeichnen. Perspektivisch halten wir es für wahrscheinlich, dass begrenzungslogische Lebensmaximen in Gestalt des achtsamen Lebens und insbesondere des nachhaltigen Lebens wichtiger werden. Angesichts des hohen subjektiven Gratifikationspotenzials der postmodernen Konsumgesellschaft ist allerdings von einer starken Beharrungskraft der Steigerungslogik auszugehen – und damit auch der Erlebnisorientierung.
Warum gibt es in Ostdeutschland weniger einwanderungsbezogene Bildungsungleichheit? Bedingungen der Bildungsbeteiligung und Lesekompetenz von Heranwachsenden mit Einwanderungsgeschichte in Ost- und Westdeutschland
Authors: Winkler Oliver , Jansen Malte , Edele Aileen
Published: August 2022

Wir untersuchen mit Daten der IQB-Ländervergleiche und Bildungstrends 2008/2009, 2012 und 2015, ob (1.) Disparitäten in der Bildungsbeteiligung und Lesekompetenz von Lernenden aus eingewanderten und nicht eingewanderten Familien in Ostdeutschland geringer ausgeprägt sind als in Westdeutschland und (2.) ob die geringere einwanderungsbezogene Bildungsungleichheit in Ostdeutschland auf geringere Unterschiede in (a) der sozialen Herkunft, (b) der sozialen Schulklassenzusammensetzung und (c) der frühkindlichen Bildung zurückgeführt werden kann. Es zeigt sich, dass in Ostdeutschland geringere oder teilweise keine einwanderungsbezogenen Bildungsdisparitäten bestehen, es ergeben sich sogar Bildungsvorteile für Jugendliche der zweiten Einwanderungsgeneration im Gymnasialbesuch. Ferner ist die geringere einwanderungsbezogene Ungleichheit in der Gymnasialbeteiligung und Lesekompetenz in Ostdeutschland auf geringere einwanderungsbezogene Ungleichheit in der sozialen Herkunft und sozialen Komposition der Schulklassen zurückzuführen.
A four-fold three-dimensional zinc(II) coordination polymer based on 4,4′-bis(2-methyl-imidazolyl)biphenyl and 5-sulfoisophthalate ligands: synthesis, structure and properties
Authors: Jiang Weina , Zhou Lin , Jiang Haijian , Cheng Weiwei , Xue Yun-Shan
Published: August 2022

A Zn(II) coordination polymer, [Zn3(4,4′-BMIBP)3(SIP)2]
n
(1) (4,4′-BMIBP = 4,4′-bis(2-methyl-imidazolyl)biphenyl, H3SIP = 5-sulfoisophthalic acid) was hydrothermally synthesized and structurally characterized. Complex 1 has a (3,4)-connected binodal four-fold three-dimensional topology with a point symbol of {4·62·82·10}2{4·62}2{64·102}. It shows strong fluorescence emission in the solid state and efficient photocatalytic performances to degrade methylene blue (MB) under UV irradiation, the degradation of MB reaching 88% after 50 min.
Effectiveness of mRNA COVID-19 Vaccines in Adolescents Over 6 Months
Authors: Amodio Emanuele , Genovese Dario , Mazzeo Luca , Martino Luca , Restivo Vincenzo , Vella Giuseppe , Calamusa Giuseppe , Vitale Francesco
Published: August 2022

BACKGROUND AND OBJECTIVES

On June 4, 2021, Italy launched the coronavirus disease 2019 (COVID-19) vaccination of adolescents to slow down the COVID-19 spread. Although clinical trials have evaluated messenger ribonucleic acid (mRNA) vaccine effectiveness in adolescents, there is limited literature on its real-world effectiveness. Accordingly, this study aimed to estimate the effectiveness of mRNA COVID-19 vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mild or severe COVID-19 in a cohort of Sicilian adolescents within a 6 month observation period.

METHODS

A retrospective cohort study was conducted with adolescents aged 12 to 18 years, residents of Sicily, who were followed from July 15 to December 31, 2021. SARS-CoV-2 infections, mild and severe COVID-19, and COVID-19-related intubation or deaths during the study period were compared between subjects vaccinated with 2 doses of mRNA vaccines and unvaccinated individuals. The Cox regression analysis, adjusted for age and sex, was performed to compare the 2 groups.

RESULTS

Overall, the study included a total at-risk population of 274 782 adolescents with 61.4% of them having completed the vaccination cycle by the end of the study. Unvaccinated subjects had higher incidence rates of SARS-CoV-2 (1043 × 10 000 vs 158.7 × 10 000 subjects), mild COVID-19 (27.7 × 10 000 vs 1.8 × 10 000 subjects) and severe COVID-19 (1.41 × 10 000 vs 0 subjects) compared with the vaccinated population. The estimated adjusted vaccine effectiveness against SARS-CoV-2 infection was 71.2%, reaching 92.1% and 97.9% against mild and severe COVID-19, respectively.

CONCLUSIONS

This study provides rigorous evidence of mRNA COVID-19 vaccines’ effectiveness in protecting adolescents from both SARS-CoV-2 infection and COVID-19.
Europäische Lyrik seit der Antike
Authors: Schramm Tim , Lohse Gerhard , Gölz Christine , Meyer-Minnemann Klaus , Friedrich Michael
Published: August 2022

Seit der griechisch-lateinischen und jüdisch-christlichen Antike und in immer erneuten Rückgriffen auf diese beiden Traditionen haben die Völker Europas einen großen Schatz von Gedichten geschaffen, die die Epochen ihrer Geschichte zum Ausdruck gebracht und selbst mit geformt haben. Während Mythos, Epos und Roman die großen Geschichten der Welt und der Götter, der Völker und Helden erzählt haben, hat das Gedicht schon früh die Ich-sagende Stimme geschaffen und ihr so ermöglicht, sich in den großen und kleinen Ereignissen der Zeit zu Gehör und Geltung zu bringen; Gefühle, Haltungen, Werte auszuprobieren und so neue Mentalitäten vorzubereiten. Diese Arbeitsteilung zwischen Gedicht und Erzählung bleibt in den Vorlesungen dieses Buches immer im Blick, weil sie die inzwischen entwickelten Zugriffsweisen der Erzählforschung, der Narratologie, nutzen, um die besonderen Möglichkeiten der Lyrik zu entdecken. So sieht man klarer, welche Rolle Gedichte und Lieder spielen in der Subjektivierung der Religion und der Liebe seit den Reformationen, wie sie die Freisetzung des Individuums in der Aufklärung fördern und eine neue Natur- und Kunstreligion einüben, den Nationalismus des 19. Jahrhunderts stimulieren und mit gewagten Experimenten neue Haltungen im Prozess der modernen Zivilisation einzunehmen. Die Fachdisziplinen haben diesen gemeinsamen Schatz untereinander verteilt und damit fast aus den Augen verloren. Die öffentliche Vorlesung aber hat ihn den Beteiligten wieder sichtbar gemacht, immer am Beispiel und in einer allen zugänglichen Sprache, die in diesem Buch erhalten geblieben ist.
Albuminuria and HIV-infection in pediatric patients
Authors:   Dnipro State Medical University, Ukraine, Borysova T.P. , Allakhvierdiiyeva Z.S. ,   Dnipro State Medical University, Ukraine
Published: August 2022

HIV infection increases the risk of developing chronic kidney disease (CKD). Diagnosis at an early stage of HIV associated kidney disease in children is of particular importance, given its prevalence. Determination of the concentration of albumin and creatinine in a single portion of urine, followed by the calculation of the albumin/creatinine ratio (ACR) is used for early diagnosis and assessment of the progression of CKD. Purpose - to study the frequency and risk factors of albuminuria in children with HIV infection, depending on the stage of the disease, immunosuppression, and viral load. Materials and methods. 73 children with HIV infection were examined. Albumin was analyzed in the morning urine sample twice (during the first and third months of observation) using a Beckman Coulter AU 480 series analyzer. Albuminuria was assessed by ACR. The criterion for a moderately elevated level of albuminuria was considered as ACR ≥3 mg/mmol in both measurements and was interpreted as the presence of microalbuminuria (MAU). Results. A steady increase in ACR was noted in 19 (26.0%) patients. The influence of the stage of HIV-infection on the level of albuminuria has not been established. Non-significant immunosuppression (IS) sharply reduced the chances of MAU - OR=0.019 (CI: 0.002-0.159), the presence of a very severe stage of IS significantly increased them - OR=18.89 (CI: 4.33-82.32). There was a pronounced inverse correlation between the ACR and the CD4+ count, both absolute (ρ=-0.51; p<0.001) and relative (ρ=-0.53; p<0.001). It was found that against the background of viral load, the average ACR was twice as high, and the percentage of MAU was nine times higher. In the case of normal viral overload, the chances of moderately elevated albuminuria were significantly reduced - OR=0.048 (CI: 0.012-0.194). The highest rates of ACR were observed in children with a viral load of more than 100,000 copies of RNA/ml, among these patients, MAU was stated in ¾ of cases. A high viral load increased the risks of MAU by one and a half orders of magnitude - OR=15.30 (CI: 3.51-66.68). Elevated ACR was recorded 3.6 times more often in children with progressive HIV-infection than in other patients (OR=14.13; CI: 1.47-136.12; p<0.02). Conclusions. More than a quarter of children with HIV-infection have moderately elevated albuminuria. Renal dysfunction in children with HIV infection has been most closely associated with very severe immunosuppression, RNA HIV viral load >100,000 copies/ml, and progressive course of HIV-infection, as evidenced by albuminuria studies. The study was carried out in accordance with the principles of the Declaration of Helsinki. The study protocol was adopted by the Local Ethics Committee of the institution specified in the work. The informed consent of the parents or guardians of the children was obtained for the study. The authors declare no conflict of interest. Key words: HIV infection, children, albuminuria, risk factors.