bluuebunny/crossref_metadata_2025 huggingface dataset:
Kiss1 kisspeptin of bony fish and mammalian kisspeptin analogs enhance the communicative behavior of Danio rerio induced by social isolation
Authors: Goltz Vladanka A. , Lebedev Andrey А. , Eresko Sergei O. , Airapetov Marat I. , Pyurveev Sarng S. , Bychkov Evgenii R. , Bayramov Alekber A. , Lebedev Viktor A. , Shabanov Petr D.
Published: June 2024

BACKGROUND: Rodents are often used as a social isolation model. This study investigated the effects of social isolation on Danio rerio. These animals form groups and social hierarchies and exhibit complex social interactions similar to rodents. The expression of some brain genes of fish reared in isolation was found to be different from individuals reared in a group.
AIM: This study aimed to investigate the effect of kisspeptins on the social behavior of Danio rerio in social isolation.
MATERIALS AND METHODS: Fish were placed in 200-mL measuring cups for 48 h. After the social isolation period, bony fish kisspeptins and mammalian kisspeptin analogs were administered, and their effects were tested. The animal was placed in 1-L individual tanks for 15 min and then in the tank with a glass partition, behind which are a group of congeners. Fish were allowed to approach or swim away from the partition. Two patterns were used to assess behavior: latency time and number of swims to the partition.
RESULTS: Compared with the control group with fish kept in social isolation, reliable differences were observed: The number of swims to the partition after isolation was 1.3 times higher than that in the control group (p 0.05). After the administration of bony fish kisspeptins Kiss1 and Kiss2, no significant changes in the number of swims to the partition were observed. Moreover, after the administration of KS6 and KS10, the number of swims to the aquarium partition increased 1.6 times (p 0.01) and 1.8 times (p 0.001), respectively. After the administration of the comparison drug oxytocin, the number of swims to the aquarium partition increased 1.6 times (p 0.01) compared with that in the untreated isolated group. The latency time of swimming to the partition increased 2.4 times in the untreated isolated group compared with the control group (p 0.001). Latency time decreased 2.3 times in the group administered with oxytocin compared with the untreated isolated group (p 0.001). In the group administered with Kiss1, the latency time decreased 2 times (p 0.001) compared with that in the untreated isolated group. The latency time decreased 5 times (p 0.001) after KS10 administration and 3.4 times (p 0.001) after KS6 administration compared with that in the untreated isolated group.
CONCLUSIONS: Thus, social isolation in Danio rerio reduces communicative behavior. Analogs of mammalian kisspeptin, such as Kiss1, of bony fish and oxytocin normalize the communicative behavior of fish after a period of social isolation to the level of the control group.
Modern view on the effectiveness and safety of non-steroidal anti-inflammatory drugs
Authors: Shamal Liliya L. , Shelemekh Olga V. , Murashko Roman A. , Glechyan Tereza R. , Galenko-Yaroshevskii Pavel A.
Published: June 2024

Issues of the effectiveness and safety of drugs remain relevant and controversial. The benefits and risks of drug therapy are two facets of one whole, called pharmacotherapy, which can have undesirable side and even negatively outweigh the benefits. The effectiveness and safety of drugs must be studied comprehensively because new effects of drugs may be discovered and new mechanisms for unregistered indications may be revealed. Moreover, a deep understanding of adverse drug reactions will allow for the accurate prescription of drugs and proper medical supervision of therapy. Nonsteroidal anti-inflammatory drugs are over-the-counter drugs perceived by patients as safe and do not require a doctor’s prescription, which can cause dangerous drug reactions, particularly when used uncontrollably. The review presents literature data from studies on the effectiveness of nonsteroidal anti-inflammatory drugs and current data on new therapeutic effects of individual drugs, risks of adverse reactions, their mechanisms, and treatment methods.
Molecular Targets of Cannabidiol warn against its consumption during pregnancy
Authors: Bates Emily , Oh Won
Published: June 2024

People use cannabidiol (CBD), the primary non-psychoactive cannabinoid of cannabis, as a treatment for symptoms that are commonly associated with pregnancy including nausea, pain, and anxiety. Many people believe CBD is safe to take during pregnancy. However, CBD crosses the placenta and affects the activity of protein targets that are expressed in the fetal brain. Cannabidiol alters the activity of ion channels including voltage- gated sodium, potassium, and calcium channels that control the electrical activity of neurons. Abnormal electrical activity could disrupt brain function via changes in axon growth and synapse structure and function. Furthermore, CBD alters the activity of G- protein coupled receptors that are expressed in the fetal brain and are important for axon growth and guidance suggesting that fetal exposure could prevent axons from reaching their correct targets. Indeed, cannabidiol exposure reduces axon growth in vitro and in vivo. This raises the possibility that CBD consumption during pregnancy could disrupt fetal brain development. Recent studies show that oral cannabidiol consumption during pregnancy alters the excitability of the pyramidal neurons of the prefrontal cortex and affects postnatal cognitive function in mouse offspring. Furthermore, fetal CBD exposure increases thermal pain sensitivity in offspring. Gestational cannabidiol exposure affects compulsivity and memory in a different rodent model. Here, we discuss how CBD affects various ion channels and G-protein coupled receptors, the roles of these proteins in neurodevelopment, and evidence that CBD affects brain development.
Efficacy and safety of paracetamol, phenylephrine, chlorpheniramine maleate and sodium citrate in Indian paediatric patients with common cold: an active post-marketing surveillance study
Authors: Kiran Mayuresh D. , Pawaskar Lalit J. , Waghambare Pramita D. , Singh Aakansha V.
Published: June 2024

Background: The common cold, mainly caused by viruses, brings discomfort to children with symptoms like sneezing, congestion, runny nose, and sore throat. As no specific antiviral treatments are available to relieve common cold symptoms, it is typically managed using decongestants, antihistamines, and antipyretics. This study aims to assess the safety and efficacy of a fixed-dose combination (FDC) of paracetamol, phenylephrine, chlorpheniramine maleate and sodium citrate in children aged 2 to 12 years with common cold.
Methods: This non-randomized, open-label, non-comparative, active post-marketing surveillance (PMS) study was conducted across multiple centres in India, involving 417 patients. The study assessed efficacy using the total symptom score (TSS) scale over 5 days with visits on days 1, 3, and 5. Safety was evaluated based on adverse events reported by patients on days 3 and 5 of the trial.
Results: Initially, 417 patients were enrolled in the active PMS, of which 309 completed the study. The mean TSS showed a notable decrease from 8.95 at visit 1 to 0.19 at visit 3, depicting a significant reduction i.e., 97.90% as compared to baseline. At visit 1, most patients (95.79%) exhibited severe symptoms, whereas by visit 3, 83.82% were symptom-free, with only 16.18% experiencing mild symptoms.
Conclusions: This active PMS study examined the safety and efficacy of an FDC of paracetamol, phenylephrine, chlorpheniramine maleate and sodium citrate in treating common cold in children in India. The findings indicate a significant reduction in symptoms, with many patients becoming symptom-free by the third visit, demonstrating its efficacy and safety.
Longitudinal Links between Career Maturity and Self-Directed Learning in Low-Income College Students Receiving Scholarships
Authors:   The Korea Association of Yeolin Education, Park Hyunjung , Kim Minkyung
Published: June 2024

The purpose of this study was to understand the trajectory of career maturity changes in low-income college students who receive scholarships, and to examine the influence of self-directed learning on changes in career maturity. To achieve this, data from a longitudinal study on educationally disadvantaged children and adolescents provided by the S Foundation from 2019 to 2023 was analyzed for 395 students (151 males and 244 females) who were in the early years of university (1st and 2nd year) in 2019. The results are as follows. First, by examining the trajectory of changes in career maturity, it was confirmed that the career maturity of low-income college students significantly linearly increased with grade progression. Second, when analyzing individual differences using self-directed learning abilities as a time-varying covariate, the immediate effects of self-directed learning were significantly presented, but the delayed effects were not significant. Based on these results, the implications and limitations of this study were discussed.
Features of associations of SHBG-related genes with breast cancer in women, depending on the presence of hereditary burden and mutations in the BRCA1/CHEK2 genes
Authors:   Belgorod State National Research University, Pasenov Konstantin N.
Published: June 2024

Background: One of the most common diseases of the female population is breast cancer (BC), which is a hormone-dependent pathology and has a significant hereditary component. Candidate genes that determine the concentrations of the protein transporting sex hormones (SHBG) in the body may be promising genetic risk factors for the development of BC. The aim of the study: To evaluate the features of associations of SHBG-related genes with BC in women, depending on the presence/absence of hereditary burden and mutations in the BRCA1/CHEK2 genes. Materials and methods: A sample of BC patients (n=358) depending on the presence/absence of a burdened family history (n=68 and n=290, respectively), as well as depending on the presence/absence of mutations in the BRCA1/CHEK2 genes (n=26 and n=332, respectively), was divided into appropriate subgroups for comparative genetic analysis with the control group (n=1140). The paper considers nine polymorphisms of SHBG-significant genes – PRMT6 (rs17496332), GCKR (rs780093), PPP1R21 (rs10454142), BAIAP2L1 (rs3779195), ZBTB10 (rs440837), JMJD1C (rs7910927), SLCO1B1 (rs4149056), NR2F2 (rs8023580), SHBG (rs12150660). Associations were studied using logistic regression. Results: Significant differences were found in the involvement of SNP SHBG-related genes in the predisposition to BC, depending on the presence/absence of a burdened family history and mutations in the BRCA1/CHEK2 genes in patients. SNP rs10454142 PPP1R21 is associated with BC in women who do not have a burdened family history of BC (risk allele – C; additive model OR=1.32 95%CI=1.03-1.70 p=0.027 pperm=0.027), and in women who had no mutations in the BRCA1/CHEK2 genes (risk allele – C; additive model OR=1.34 95%CI=1.05-1.70 p=0.017 pperm=0.017; recessive model OR=1.74 95%CI=1.05-2.86 p=0.030 pperm=0.034). At the same time, among women who have BC-burdened heredity or mutations in the BRCA1/CHEK2 genes, polymorphic variants of SHBGrelated genes do not have an independent effect on the risk of developing the disease. Conclusion: rs10454142 PPP1R21 polymorphism is a risk factor for breast cancer in women without burdened heredity and in women without mutations in the BRCA1/CHEK2 genes.
Targeting the Bap1 protein of Vibrio cholerae for screening potent inhibitors and predicting the mutant protein stability: in silico analyses
Authors:   PSG College of Arts & Science, Gowtham Kalidas , Pranav Rithish J. ,   Karpagam Academy of Higher Education
Published: June 2024

Background: Bap1 is reported to be a major protein in Vibrio cholerae which aids in biofilm formation. Hence, inhibition of the protein molecule can no longer support the colonization of bacteria and induction of point mutations at specific amino acid residues tend to reduce the protein stabilization. The aim of the study: To target this Bap1 structural protein for screening potent inhibitors of ligands by means of in silico analyses. Materials and methods: A total of 30 compounds divided into three groups such as synthetic antimicrobial drugs, phytochemicals and marine compounds comprising of ten ligands in each group were tested against Bap1. In addition to this, mutations were induced at GLN: 518, HIS: 520 and ASN: 679 positions to determine the stability of the mutant Bap1 protein using bioinformatic tools. Results: Of the 30 docked compounds, doxycycline, ichangin and Ageloxime D exhibited the highest binding affinities of -8.5 kcal/mol, -9.3 kcal/mol and -8.8 kcal/mol respectively from the three groups. The ADME properties show the druglikeness of the test compounds to be used for treatment procedures. Protein-ligand interactions were visualized which infer that both doxycycline and ichangin form five conventional hydrogen bonds while Ageloxime D could form three hydrogen bonds with different amino acid residues of the protein. Further, the van der Waals’ interactions are also found to be similar in number among doxycycline and ichangin whereas, it is less in case of Ageloxime D but, the π- interactions are high in this compound comparatively. The carbon-hydrogen bonding for these three compounds with the amino acid residues of the Bap1 protein have also been discussed. Conclusion: Thus, natural compounds can eventually replace the over use of synthetic drugs as antibiofilm agents. Also, inducing point mutations to this protein can potentially destabilize its structure.
Mevlânâ’da İnsanın Yaratılması Bağlamında Rahmet, İyilik ve Kötülük Tasavvuru
Authors: Kuşlu Abdullah
Published: June 2024

İnsanın yaratılması, dünyaya gönderilmesi ve iradesiyle birlikte sorumlu kılınması âlemde mevcut iyilik ve kötülüğü anlama ve anlamlandırma çabasını da kapsamaktadır. Bu açıdan âlemde iyilik ve kötülük meselesi ile ilintili olarak insanın ne olduğu ya da insanın iyilik ve kötülük vasıflarını barındırmasının ne anlama geldiği ilâhî dinlerin de sorduğu ortak sorulardandır. Dînî disiplinler içerisinde insanın ne olduğu, iyi ve kötü eylemleri bir mesele olarak Hâlık-mahlûk ilişkisi açısından tasavvufun da konusu olmuştur ve Mevlânâ da (öl. 672/1273) eserlerinde insanın iyi ve kötü vasıflarını, bir yandan insanın seçkinliği bir yandan özgürlüğü ve sorumluluğu bağlamında irdeleyen bir mutasavvıf olarak karşımıza çıkmaktadır. Bu düşünme biçimi aynı zamanda onun Tanrı, âlem, aşk, âşık, mâşuk, hayat, ölüm insanın iradesi gibi konularını da kapsayan bir yaklaşımdır. Dolayısıyla insandan bahsetmek bazen doğrudan bazen de dolaylı olarak birbiriyle ilintili farklı meseleleri de konu edinmeyi zorunlu kılmaktadır. Bununla birlikte insanın irade edebilmesi onun bir takım yerilen ve övülen vasıfları da kendinde barındıran bir varlık olduğu anlamına gelmektedir. Çünkü temyiz edebilmek iyilik ile kötülüğün birlikte var olması anlamına gelmekte olup kötülüğün de iyilikle birlikte konu edilmesini gerektirir. Bu durumda insanın seçkinliği ile onun kötülüğe olan meyli ya da kötülüğü tercih etmesi nasıl açıklanabilir? Âlemde sadece iyiliğin değil kötülüğün de mevcut olması yanında insana irade ve ihtiyar verilmesi bir lütuf olarak tasavvur edilebilir mi? Mevlânâ’nın düşüncesinde iyilik ve kötülük ya da âlemde iyilik ve kötülüğün mevcudiyeti ne anlama gelmektedir? Bu makalede insanın yaratılışı, irâdî eylemleri ve âlemde iyilik-kötülük meselesi rahmet kavramı etrafında teklif, irade ve sorumluluk açısından irdelenmekte; söz konusu meseleler Mevlânâ’nın Mesnevî’si başta olmak üzere Fîhi Mâ Fîh isimli eserleri bağlamında analiz edilmektedir. Sonuç itibariyle Mevlânâ insanın ve âlemin yaratılmasını rahmet ve lütuf olarak görürken insana irade verilmesini de onun seçkin kılınması olarak yorumlamaktadır. Bu seçkinlik ilk olarak Hakk’ı bilmeye ve insanın Hakk’a karşı sorumlu kılınmasına mâtuftur. Nitekim iyilik ve kötülük ya da hastalık ve şifa gibi zıtları barındıran bu kesret âlemi zıddı olmayan bir varlık olarak Yaratıcı’ya işaret etmektedir. Böylelikle Mevlânâ bir yandan âlemdeki delil ve işaretleri Hakk’ın kudret ve rahmetine tevdi ederken bir yandan da âlemde mevcut iyilik ve kötülüğü insanın iradesiyle bağlantılı olarak anlamlandırmaya çalışır.
ASYMPTOTIC BEHAVIOR OF SOLUTIONS OF TWO-PART DIFFERENTIAL EQUATIONS WITH EXPONENTIAL NONLINEARITY
Authors: Evtukhov V. M. , Golubev S. V.
Published: June 2024

For a two-term nonautonomous ordinary differential equation of the fourth order with an exponential nonlinearity of the form y(4) = α0p0(t)[1 + r(t)]eσy where α0 ∈ {−1,1}, σ ≠ 0, the function p0(t) is continuous or continuously differentiable and nonzero in some left neighbourhood of ω (ω ≤ +∞), r(t) is a continuous function such that limt↑ωr(t) = 0, the asymptotic behaviour at t↑ω of one class of Pω(Y0, λ0)-solutions is studied. For this equation, in [1], the necessary and sufficient conditions for the existence of such solutions were obtained in the case when λ0 ∈ R∖ {0, 1/2, 2/3, 1}. The proof of sufficient conditions for existence was carried out under some additional conditions that are quite strict. The aim of this paper is to improve the results obtained in [1] for sufficient conditions of existence. An attempt is made to extend the results of this paper to conditions that are less stringent. In contrast to [1], the proof of the main result in this paper assumes that there is a finite or infinite limit limt↑ω πω(t)q’(t).
The equation under study is reduced to a system of equations for which it is necessary to determine the existence of solutions vanishing at infinity. This fact is established using the known results of [2]. The question of the number of solutions of the equation with the found asymptotic images is also solved.
FEATURES OF THE CONSTRUCTION OF UNIFORM ASYMPTOTIC SOLUTION OF A SYSTEM OF DIFFERENTIAL EQUATIONS WITH A TURNING POINT WITH POSITIVE COEFFICIENTS OF THE MATRIX
Authors: Sobchuk V. V. , Zelenska I. O.
Published: June 2024

The work is devoted to the analysis of the coefficients of the singular operator of the Orr-Sommerfeld type in vector form including the turning point. The system of singularly perturbed differential equations with a small parameter at the highest derivative is investigated. We consider the case when the spectrum of the limit operator contains multiple and identically equal zero elements. Using the method of essentially singular functions, the uniform asymptotic solution of the system is constructed. For the case of a stable turning point, the asymptotics of the solutions of the system are constructed in the sector that contains the turning point. The asymptotics of the first two solutions for the homogeneous problem are constructed using the Airy functions and their derivatives. The third formal solution of a homogeneous system for this case presents certain difficulties. Therefore, taking into account the specified conditions, in order to construct the uniform asymptotics of the solution for the given system, we used the partial solution of the heterogeneous system as the third solution of the homogeneous system.
ON THE ASYMPTOTICS OF SOLUTIONS OF NON-AUTONOMOUS DIFFERENTIAL EQUATIONS ASYMPTOTICALLY CLOSE TO LINEAR
Authors: Stekhun A.
Published: June 2024

The necessary and sufficient conditions are obtained for the existence of all possible types of Pω(Y0, λ0)-solutions of non-autonomous second and third-order ordinary differential equations that are asymptotically close to linear equations. The asymptotic representation of each possible type of Pω(Y0, λ0)-solutions has been determined, and the question of their quantity has been clarified. Consequences have also been derived from the obtained theorems for cases when the equation is a linear differential equation.
Civil Procedure and Labor Law on the Immediate Enforcement of Court Rulings in Individual Labor Disputes
Authors:   Associate Professor of the Department of Land, Labor and Environmental Law of the Kuban State Agrarian University Named after I.T. Trubilin, PhD (Law), Associate Professor, Novikova Yulia A.
Published: June 2024

The article is devoted to the analysis of the Civil Procedure Code of the Russian Federation and the Labor Code of the Russian Federation on the immediate execution of decisions and court orders in disputes about reinstatement at work and collection of wages, the article notes the differences in the codes on this issue, and suggests options for resolving conflicts between the provisions of the designated regulatory legal acts.
Peculiarities of the Regime of Appealing Court Rulings in Civil Proceedings
Authors:   Lecturer of the Department of Labor, Environmental Law and Civil Procedure of the Law Institute of the Altai State University, Timofeev Evgeniy I.
Published: June 2024

The work is devoted to the study of legislative and law enforcement restrictions on challenging individual court rulings. It has been established that legal facts, including deadlines, and subjective rights are used as means of legal regimes in this case, in particular. These funds have a significant stimulating or disincentive effect on participants in the proceedings. In addition, the lack of legal regulation may have an impact on the participants in the process. As an example, the article considers the appeal of the ruling on the abandonment of the statement of claim without motion and on the transfer of the case by jurisdiction. The author comes to the conclusion that today there is a regime of unfavorable appeal of court rulings. As a result, there are abuses of the participants in the process, red tape on the part of the court. The solution to these problems is the establishment of disciplining and enforceable deadlines on the part of the participants, taking into account the interests of the participants in the formulation of their rights, as well as individual legal structures.
Professional Risks in Lawyer Activity
Authors:   Professor of the Department of Legal Disciplines of the Faculty of Law and Economics of the Moscow Economic Institute, Attorney at Law Office No. 2 of the Moscow City Bar Association, LL.D., Associate Professor, Vasyaev Aleksandr A. , Marcheva Polina E. ,   Associate Professor of the Department of Advocacy of the Kutafin Moscow State Law University (MSAL), Attorney at Pravovik-K Moscow City Bar Association, PhD (Law), Associate Professor
Published: June 2024

Advocates in their activities face numerous risks that cannot but affect the effectiveness of protecting the rights, freedoms and legitimate interests of individuals and organization. The purpose of the article is to identify these risks and explore ways to minimize them both within the framework of legislative activity, and in theory and practice. Increasing the level of legal awareness and legal culture of society is also inextricably linked with overcoming by representatives of the legal profession, including advocates, those challenges that pose professional risks to them.
STUDENTS’ ERRORS IN PROBLEM-SOLVING REVIEWED FROM THE PERSPECTIVE OF MATH RESILIENCE
Authors: Utami Wikan Budi , Dewi Aulia Puspita , Widodo Sri Adi
Published: June 2024

The purpose of this research is to: 1) identify students' mistakes in solving mathematical problems in trigonometry in terms of mathematical resilience according to the Newman Procedure, and 2) discuss trigonometric problems from the point of view of mathematical resilience according to the Newman Procedure.  This type of research is qualitative. The research subjects were 3 students from SMA Negeri 1 Slawi, selected using a purposive sampling technique. The methods of data collection are tests, questionnaires, interviews, and documentation. The data analysis techniques used are data reduction, data presentation, and drawing conclusions.  Based on the results of the data analysis, we obtained the following: (1) Students' mistakes in reading the questions include: students do not understand the context of the sentence, students do not correctly understand the meaning, and students do not read all the meanings of the desired words. (2) The answers to the questions include: answers that do not contradict the accepted answers but do not coincide with the inquiry accepted in the question, and answers that do not address what is required in the problem posed, often being a question of application. (3) Transforming the problem includes: considering a method being investigated, using the wrong method, and not translating the method to be used. (4) Process skills contain: concept errors, errors in computing, not continuing the settlement procedure, and not processing calculations. (5) The final answer includes: an answer that fits the context of the question, and an answer that does not match the conclusion. The contributing factors include: lack of self-confidence, confusion in describing the problem in the form of a picture, hurrying in solving problems, lack of accuracy, inability to manage time well, inability to think about problems thoroughly, forgetting to identify what is suitable and trying, confusion in determining the formula to be used, and solving the problem without completing the conclusion.
Exhaust emissions from a jet engine powered by sustainable aviation fuel calculated at various cruising altitudes
Authors: Kurzawska-Pietrowicz Paula , Maciejewska Marta , Jasiński Remigiusz
Published: June 2024

The article focuses on emission analysis of non-CO2 pollutions from aircraft engines on different flight levels: FL240, FL300 and FL350. The calculation were made based on A320 flight from Berlin to Lisbon at the flight level 350, which was the reference flight level in the analysis. Four sustainable aviation fuel have been taken into consideration, which are biofuel from jatropha and biofuel from camelina in different percentage of fuel: 20% of CSPK and JSPK and 40% of CSPK and JSPK. The results showed, that the lowest emission of carbon monoxide is on the lowest tested flight level for flight on biofuel, and the lowest emission of nitrogen oxides is for Jet A-1 on the lowest tested flight level. Emission of every toxic gas compound has been compared to conventional jet fuel on the flight level 350 to show the differences between flight levels.
El papel del convenio colectivo como instrumento de transparencia retributiva
Authors: Cairós Barreto Dulce  María
Published: June 2024

La transparencia retributiva constituye un mecanismo de divulgación de información que pretende revelar el sesgo o la discriminación por razón de sexo en las prácticas salariales con la intención de poner de manifiesto la brecha de género y encontrar medidas para disminuirla o cerrarla. Con ello contribuye a la consecución de la efectiva aplicación del principio de igualdad de retribución por un trabajo igual o de igual valor. La legislación internacional, europea y española han identificado diferentes instrumentos de transparencia retributiva, destacando entre ellos el convenio colectivo, porque es la herramienta esencial y más importante en la determinación de los sistemas de clasificación profesional y los niveles y sistemas retributivos, así como de establecimiento de la estructura salarial. Será, por tanto, el convenio colectivo el responsable de enumerar y definir los puestos de trabajo adecuadamente valorados de manera neutra desde una perspectiva de género, así como de fijar los salarios y determinar sus distintos componentes con criterios objetivos, neutros y no discriminatorios. Este estudio analiza la virtualidad de la intervención del convenio colectivo, sus necesarias vías de actuación y los retos que debe afrontar para lograr no sólo salarios equivalentes por un trabajo de igual valor, sino también salarios dignos y homogeneizados al alza.
PREDICTING COLLEGE DROPOUT LIKELIHOOD BASED ON HIGH SCHOOL AND COLLEGE DATA: A MACHINE LEARNING APPROACH
Authors:   Data Analytics Department, University of Tennessee Chattanooga, Chattanooga, TN, Jain Hemant
Published: June 2024

College dropout rate is a significant problem, especially in the US higher education system. Among all undergraduate students, up to 40% drop out before completing their degree. This significantly impacts students and Universities alike financially and in wasted efforts. Previous research shows that there are early indicators of college success in the high school record such as grades, attendance, disciplinary incidents, and ACT/SAT scores. Additionally, there are factors in college experiences, especially in the first year of college which impact the likelihood of dropout. However, to the best of our knowledge, there is no comprehensive model that can accurately predict the likelihood of college dropout and provide an early warning either in high school and/or the first year of college. We were fortunate to get access to longitudinal ten-year data of high school graduates of public schools in a county in the United States and were able to follow a subset of students who went to a specific public University. Based on more than one hundred variables from high school and college records and students’ final status we trained various machine learning models to predict the likelihood of student dropout and identify factors that play a significant role. Based on this information a prototype decision support system was developed and evaluated.
WASTE MANAGEMENT USING LEAN-GREEN APPROACH: A CASE STUDY IN A FURNITURE COMPANY
Authors: Wurjaningrum Febriana , Bhaskoro Begawan Hero
Published: June 2024

Introduction: Wooden furniture is one of Indonesia's superior products, with a low-efficiency level. However, the wooden furniture industry is often associated with intense environmental degradation and high levels of waste. In anticipating waste, a green manufacturing model proposed is Lean-Green manufacturing. This current study aims to explore the implementation of the Lean-Green model in a furniture company's waste processing system and assess the effectiveness of Lean-Green implementation.
Methods: The research methodology was qualitative with the Lean-Green scoring method implemented in the supply chain of Company S. Data were collected through interviews and field observations.
Results: Company S had a low score, meaning that the interaction between the Lean and Green approaches in the waste processing of the supply chain was not optimal. The Lean-Green implementation in the wooden furniture industry was effective in evaluating waste processing in the supply chain. The research findings urge the initiatives to improve the understanding and implementation of the Lean-Green concept.
Conclusion and suggestion: The evaluation of the Lean-Green implementation helps the company’s manager improve the supply chain with sustainable measures.
CONSUMER SHOPPING BEHAVIOR IN INDONESIA AND THAILAND: HEDONIC AND UTILITARIAN SHOPPING VALUES
Authors: Pujianto Hendri , Marwati Fithri Setya
Published: June 2024

Introduction: Shopping value, which influences shopping experiences, has garnered attention and constitutes a well-studied topic in marketing. This study aimed to measure and describe differences in consumer shopping behavior between Thailand and Indonesia regarding hedonic and utilitarian values.
Methods: This study employed a quantitative, descriptive, cross-sectional survey conducted among consumers residing in Indonesia and Thailand. The respondents comprised 70 individuals aged 18 years from Surakarta City and an equivalent number from Nonthaburi City. The data distribution and collection using questionnaires were carried out for 2 months, from July to August 2023. The data analysis was performed by utilizing SPSS software. Notably, both cities are in the process of rapid development into metropolises. Most respondents were women under 25 years old.
Results: This study discovered that Indonesian and Thai consumers performed hedonic shopping behaviors. However, consumers with hedonic shopping behaviors in Thailand were more inclined towards impulsive shopping behaviors and engaged in shopping activities out of desire rather than necessity, compared to consumers in Indonesia.
Conclusion and suggestion: This study described that both Indonesian and Thai consumers had utilitarian shopping behaviors, enabling them to accomplish their objectives and procure desired items effectively during shopping endeavors. Nonetheless, consumers in Thailand display a tendency to find their desired items and prefer to shop briefly compared to their counterparts in Indonesia. Future researchers would benefit from examining the relationship between consumer behavior and other factors such as age or gender. Understanding the influence of these variables on shopping behavior is crucial for gaining comprehensive insights into consumer preferences and decision-making processes in the retail environment.
CASH WAQF FOR MICROFINANCE: A BIBLIOMETRIC ANALYSIS
Authors: Aini Zahriya Nurul
Published: June 2024

Introduction: Waqf is one of the Islamic social financial instruments, having the distinctive characteristic that waqf assets are donated voluntarily by the wakif and are permanently designated for social benefits. Waqf can be used for productive or commercial activities to generate profits by Sharia law. Cash waqf can play a role in supporting the overall development process, both in human resource development, as well as in economic and social development. This study tries to explore the role of cash waqf for microfinance which can subsequently help the people's economy.
Methods: The research method used in this research is quantitative research with bibliometric analysis. Data sources collected secondary data obtained from the Google Scholar database. Data were obtained using Publish or Perish (POP) software and analyzed using VOSviewer software.
Results: The results of this research show that, from data searches using the keywords "cash waqf", "microfinance" and "sharia microfinance" by limiting 500 papers in the 2010-2024 time period, the words "microfinance institutions" are the most frequent keywords, indicated by a darker color than other keywords.
Conclusion and suggestion: Based on the results and analysis, it can be concluded that, from year to year, research on the topic of cash waqf for microfinance is most often used. However, research on the topic of cash waqf for Sharia microfinance is still limited. Therefore, future research can be carried out regarding cash waqf for sharia microfinance. Cash waqf plays an important role in supporting the overall development process, both in human resource development, as well as in economic and social development. The potential of cash waqf can be used as a means of economic empowerment for lower-middle-class communities with the role played by microfinance institutions.
FINANCIAL LITERACY, INFORMALITY, AND SMALL BUSINESS OPERATIONAL PERFORMANCE IN ZIMBABWE
Authors: Taruvinga Rutendo , Sakarombe Upenyu
Published: June 2024

Introduction:  The exponential growth of small and medium enterprises (SMEs) in many developing economies is a well-documented phenomenon in business literature. However, research indicates that the expansion of most SMEs is hindered by financial illiteracy and high levels of informality, posing significant challenges to their performance and long-term sustainability. Concerns arise from the fact that only a small fraction of these enterprises successfully transition into larger firms. This study sought to address these issues by investigating the levels of financial literacy among 120 SMEs operating in Harare and Bindura, taking into account the pervasive informality within the sector. The research also aimed to evaluate the relationship between financial literacy and SME operational performance.
Methods: Employing a quantitative approach within an explanatory research design, data collection was facilitated through a structured questionnaire. To capture the diverse landscape of SMEs operating in an informal context, both purposive and convenience sampling methods were utilized to select participants for the survey. Descriptive and inferential analyses were conducted using SPSS software.
Results: The findings of the study revealed a significant positive impact of financial literacy on SME operational performance, indicating that advanced financial literacy can contribute to enhanced business outcomes. Moreover, the research observed an improvement in financial literacy within SME operations, evidenced by increased awareness and application of financial management skills.
Conclusion and suggestion: The study recommends that efforts to promote financial literacy among SMEs should be intensified through advanced financial education initiatives, awareness campaigns, and enhanced financial inclusion strategies. Financial service providers are encouraged to play a proactive role in supporting SME growth by investing in financial awareness programs, funding educational initiatives, and actively engaging SMEs in key economic policy frameworks. Ultimately, SMEs are urged to fully embrace financial literacy as a fundamental pathway for achieving sustainable growth and long-term business success amidst the challenges of informality.
CONTRIBUTION OF FOREIGN DEBT, SUKUK, AND BONDS IN INDONESIA'S ECONOMIC GROWTH
Authors: Maharani Devi Widhia , Widyastuti Emy
Published: June 2024

Introduction: Indonesia's economic growth experiences unstable conditions from year to year, The study explores their impact on Indonesia's inability to overcome government spending problems by comparing three alternative sources of Indonesian state income to support economic growth, namely foreign debt, Sukuk, and bonds.
Methods: The research uses a quantitative approach derived from secondary data in the form of time series data. Foreign debt has a negative effect on Indonesia's economic growth, while sukuk and bonds have a positive effect on Indonesia's economic growth.
Results: The simultaneous result is 0.948, meaning that the independent variables (foreign debt, Sukuk, and bonds) have an influence and can be explained by 94.8% of Indonesia's economic growth. Meanwhile, the remaining 5.2% is explained by other variables that are not in this research. This indicates that the foreign debt sukuk and bonds variables have a big influence on Indonesia's economic growth in 2016-2023.
Conclusion and suggestion: Foreign debt must be controlled properly by the state so that an economic crisis does not occur in Indonesia. Apart from that, the government must increase the issuance of sukuk and bonds to meet the needs of the deficit APBN.
Retrospective weather analysis explains regular occurrence of House Swifts Apus nipalensis and swiftlets Aerodramus spp. in north-western Australia
Authors:   School of the Environment, and Research and Recovery of Endangered Species (RARES) Group, University of Queensland, St Lucia QLD 4072, Australia, Jackett Nigel
Published: June 2024

Predicting the occurrence of species involves consideration of many environmental and biological factors. For rare, mobile and dispersive trans-continental species, the challenges involved are even greater. Daily weather observations between November 2017 and April 2023 were analysed to identify patterns associated with 48 observations of House Swifts Apus nipalensis and swiftlets Aerodramus spp. – species considered national vagrants – at a site in northern Western Australia. Relatively strong winds from the north-east associated with a tropical cyclone or low-pressure system were conducive to House Swift and swiftlet occurrence, between December and May. It is anticipated that the weather conditions identified will assist with predicting future occurrences, and thereby facilitating research opportunities for these enigmatic taxa.
Quantum Solution of Classical Turbulence Decaying Energy Spectrum
Authors: Migdal Alexander
Published: June 2024

This paper summarizes and elaborates on recently found \cite{migdal2023exact} exact reduction of decaying turbulence in the Navier-Stokes equation in $3 + 1$ dimensions to a Number Theory problem of the statistical limit of the Euler ensemble. We reformulate the Euler ensemble as a Markov chain and show the equivalence of this formulation to the \textbf{quantum} statistical theory of $N$ fermions on a ring, with an external field related to the random fractions of $\pi$. We find the solution of this system in the turbulent limit $N\to \infty, \nu \to 0$ in terms of a complex trajectory (instanton) providing a saddle point to the path integral over the density of these fermions. This results in an analytic formula for the observable correlation function of vorticity in wavevector space. This is a full solution of decaying turbulence from the first principle without approximations or fitted parameters. We compute resulting integrals in \Mathematica{} and present effective index $n(t) = -t E'(t)/E(t) $ for the energy decay as a function of time Fig.\ref{fig::NPlot} and $s(k)= -k\partial_k \log E(k,t) $ for the energy spectrum Fig.\ref{fig::SPIndex}. The asymptotic values are $n(\infty) = \frac{5}{4}, s(\infty) = \frac{7}{2}$, but the universal functions $n(t), s(t)$ are neither constant nor linear due to quantum effects (complex poles of the Mellin transform at zeros of Riemann zeta function). The theoretical value $n(\infty)=\sfrac{5}{4}$ matches the grid turbulence experiments \cite{GridTurbulence_1966} within experimental errors $\sim 2\%$.
Characteristic Metabolites and Antioxidant Activities of Essential Oils from Phlomoides rotata (Benth. ex Hook. f.) Mathiesen
Authors: Pan Zheng , Xie Chen , Luo Jie , Yan Xiao Tong , Su Yong Mei , Wang Jian , Khan Nasir Mehmood , Ahmad Shujaat
Published: June 2024

Limited research has been conducted on the metabolites present in the essential oils (EOs) of Phlomoides rotata (Benth. ex Hook. f.) Mathiesen (PR, syn. Lamiophlomis rotata (Benth.) Kudô), and their potential pharmacological activities, such as antioxidant properties, are often overlooked. We conducted a metabolomics-based screening to identify the characteristic metabolites (CMs) in the EOs extracted from PR. Meanwhile, we evaluated their in vitro antioxidant activities (AOAs). The EOs obtained through hydro-distillation are characterized by a light yellow color and a fresh, elegant fragrance. Cryoprecipitation was used to separate the crystals (Crs) from the EOs, resulting in the crystal-free EOs (CFs). A total of 121 components are identified and quantified in the EOs, Crs, and CFs. Among them, 84 were reported for the first time from such EOs. The major compounds include long-chain fatty acids (LCFAs) and their esters, such as palmitic acid (PA), myristic acid (MA), linoleic acid (LA), oleic acid (OA), stearic acid, and methyl palmitate (MP). Furthermore, 11 kinds of apocarotenoids (also called norisoprenoids) were first systematically investigated. Among them, eight C13-norisoprenoids, with trans-β-damascenone (DN) being particularly notable for its flavor, were identified. A sum of 11 CMs are screened , including PA, MA, LA, OA, MP, hexahydrofarnesyl acetone, phytol (PT), DN, stearic acid, linalool, and hexanal. These CMs are biosynthesized through FAs and 2-C-Methyl-D-erythritol 4-phosphate/1-Deoxy-D-xylulose 5-phosphate pathways. The in vitro AOAs of EOs, Crs, CFs, and seven selected CMs (PA, MA, LA, OA, MP, PT, and DN) were evaluated. Generally, PA and MA exhibited pro-oxidant activities (POAs) or weak AOAs. LA and OA demonstrated POAs or weak AOAs at lower concentrations, but at higher concentrations, they displayed medium to strong AOAs. Importantly, the CFs typically exhibited stronger AOAs compared to the corresponding EOs and Crs, potentially due to variations in their PA content. Overall, this study provides valuable insights into the potential utilization of EOs from PR.
Unpacking Trastuzumab-Induced Cardiomyopathy: A Cardiac Conundrum
Authors: Peshin Supriya , MODI SHIVANI , Namburu Lalith , Rathod Malay
Published: June 2024

Cardiovascular diseases are one of the most common causes of death in the United States
of America and the sudden rise of patients having cancer are suffering from cardiovascular
side effects of Chemotherapeutics drugs. Trastuzumab is a potent targeted agent for
HER2-positive cancers though despite its excellent efficacy, the cardiotoxic effects of
Trastuzumab restrict its usage globally. The most severe adverse effect is cardiotoxicity
presents as contractile dysfunction that is reduction in left ventricular systolic function but
the electrophysiological side effects are still not known. Due to these severe life-threatening
side effects, it routinely results in the cessation of Trastuzumab. This review aims to provide
a comprehensive overview of Trastuzumab-induced cardiomyopathy, offering insights into
the mechanisms through which Trastuzumab exerts its cardiotoxic effects, clinical
manifestations, diagnostic strategies, and potential cardioprotective interventions. By
shedding light on the multifaceted aspects of this condition, we hope to emphasize the
importance of early detection and effective management, while highlighting the urgent need
for continued research to optimize the balance between oncological success and
cardiovascular well-being. Cardiologists, oncologists, and researchers stand at the forefront
of this critical intersection between oncology and cardiology, collectively striving to improve
patient outcomes in the era of Trastuzumab therapy.
Application of Artificial Intelligence (AI) in Sustainable Building Lifecycle; A Systematic Literature Review
Authors: Adewale Bukola Adejoke , Ene Vincent Onyedikachi , Ogunbayo Babatunde Fatai , Aigbavboa Clinton Ohis
Published: June 2024

With buildings accounting for a significant portion of global energy consumption and greenhouse gas emissions, the application of artificial intelligence (AI) holds promise for enhancing sustainability in the building lifecycle. This systematic literature review addresses the current understanding of AI's potential to optimize energy efficiency and minimize environmental impact in building design, construction, and operation. A comprehensive literature review and synthesis were conducted to identify AI technologies applicable to sustainable building practices, examine their influence, and analyze the challenges of implementation. The review was guided by a meticulous search strategy utilizing keywords related to AI application in sustainable building design, construction, and operation. The findings reveal AI's capabilities in optimizing energy efficiency through intelligent control systems, enabling predictive maintenance, and aiding design simulation. Advanced machine learning algorithms facilitate data-driven analysis and prediction, while digital twins provide real-time insights for informed decision-making. Furthermore, the review identifies barriers to AI adoption, including cost concerns, data security risks, and challenges in implementation. AI presents a transformative opportunity to enhance sustainability in the built environment, offering innovative solutions for energy optimization and environmentally conscious practices. However, addressing technical and practical challenges will be crucial for the successful integration of AI in sustainable building practices.