bluuebunny/crossref_metadata_2025 huggingface dataset:
Visual merchandising: Uma análise bibliométrica e proposta de pesquisas futuras
Authors: Batista Karen , Martins Ingrid de Matos , Limongi Ricardo
Published: October 2020

Este trabalho teve como objetivo investigar os estudos sobre visual merchandising em aspectos teóricos, metodológicos e empíricos. Foi realizada uma pesquisa bibliométrica a partir de 35 artigos publicados em periódicos. As análises apresentam o número de artigos por ano, principais periódicos, referências mais citadas, palavras-chave mais utilizadas, além da metodologia considerando abordagem, método de pesquisa, técnica de coleta e análise de dados. Foi possível concluir que o tema é relativamente novo justificando oportunidade para futuras pesquisas. Neste sentido, é proposta uma agenda de pesquisa com três possíveis caminhos a serem seguidos por estudos futuros, sendo: estudos com abordagem qualitativa, comparação entre diferentes países e comparação entre setores e intersetor.
Innovative principles of electric power supply of non-traction power consumers of railway transport
Authors:   Ural state university of railway transport (USURT), Bondarenko A. V.
Published: October 2020

The issues of fundamental changes of electric power-supply of non-traction devices, such as, line-section devices and systems of railway transport are addressed in the article. It is clearly shown that the possibility of electric power-supply of such consumers without using the common high-voltage line-section power-supply lines of alternative voltage of 6 or 10 kV and respective power-supply substations can be implemented in practice. The essence of the proposed is that the electric power-supply source is not a high-voltage power-supply line, but a device which converts potential mechanical energy of a train, moving along a line section between signal points of railway automatic block system, into electrical one. Putting the described power-supply devices into operation provides technical as well as economic advantages over currently and widely used power-supply systems. The conversion of energy is carried out by changing magnetic resistance of a magnetic circuit, which includes railway car wheel-set in motion and direct neodymium magnet. Change in magnetic resistance due to the law of electromagnetic induction results in alternate voltage in the inductance coil, which is used as the electric power-supply source for non-traction line-section power consumers, including but not limited to, signal point of railway automatic block system. In case there is no wheel-set on the converter, electric power-supply for the power consumer is delivered by the electric energy accumulated in an ionistor (supercapacitor).
Modelling of contractor-customer’s actions when carrying out procurement procedures
Authors:   Ural state university of railway transport (USURT), Say V. M. , Tihonov P. M. ,   Ural state university of railway transport (USURT)
Published: October 2020

The necessity of taking into consideration the impact of «digital» economy on business-processes as well as timeliness of formalisation and automation of resource provisioning in network organisational structures are presented in this article. The constituent parts influencing the emergence of resource flows in network organisational structures are distinguished. The assumption concerning parallelism of processes on the part of the customer and contractor for the purpose of eventual formalisation and automation is made. The timeliness of consideration and studying of competitive means of carrying out procurement procedures as the most complex ones, which fulfil probabilistic nature of quality of the final results are pointed out in the article. The result of a procurement procedure is the emergence of a resource flow. The methodological framework for modelling is worked out when carrying out a competitive procurement procedure on the part of a customer. This methodology includes segregation and mathematical formalisation of every stage of a procurement process. In order to formalise the stages of the procurement process a general logical flowchart is elaborated as well as the detailed ones for every segregated stage. The detailed treatment involves segregation of the main drivers, affecting the result of functioning of each specific stage. Under mathematical formalisation and segregation of drivers the correlations are indicated which have influence upon calculation of parameters of a procurement procedure and the final result of functioning of the entire model.
On a stable approximate solution of an ill-posedboundary value problem for the metaharmonic equation
Authors: Laneev Evgeniy B. , Lesik Polina A. , Klimishin Aleksandr V. , Kotyukov Aleksandr M. , Romanov Andrey A. , Khegai Anna G.
Published: October 2020

In this paper, we consider a mixed problem for a metaharmonic equation in aregion in a rectangular cylinder. On the side faces cylinder region is set to homogeneousconditions of the first kind. The cylindrical area is bounded on one side by an arbitrarysurface on which the Cauchy conditions are set, i. e. the function and its normal derivativeare set. The other boundary of the cylindrical region, which is flat, is free. This problem is illposed,and to construct its approximate solution in the case of Cauchy data known with someerror, it is necessary to use regularizing algorithms. In this paper, the problem is reducedto the Fredholm integral equation of the first kind. Based on the solution of the integralequation, an explicit representation of the exact solution of the problem is obtained. A stablesolution of the integral equation is obtained by the method of Tikhonov regularization. Theextremal of the Tikhonov functional is considered as an approximate solution. Based on thissolution, an approximate solution of the problem as a whole is constructed. The convergencetheorem of the approximate solution of the problem to the exact one is given when the errorin the Cauchy data tends to zero and when the regularization parameter is agreed with theerror in the data. The results can be used for mathematical processing of thermal imagingdata in medical diagnostics.
Informatics Open Library: Innovation in Developing Electronic- Service Case Study Departemen Informatics ITS
Authors: Mursidah Eva , Qomariyah Astutik Nur , Anggoro Radityo
Published: October 2020

Background of the study: Many of information resources available in the central library and Departemen Informatics of ITS, in various formats, printed, non- printed, electronic collections, and other media that require users to search for independent information, so users are faced with various search and location options.Purpose: This study aims to identify the problem of ability of library user to find the needs of information resources and Designing an integrated library information system in the Informatic Open Library application to solve user problems to find the needs of information resources. Method: This research uses qualitative approach with descriptive methods.Findings: Application development related to services and data security must continue to be done as well as analysis should be done every year by comparison with the analysis of the previous year to improve service quality at the highest level.Conclusion: Based on the results of research in the field, the implementation of the Informatic Open Library has been good, the aim of facilitating services for Siva ITS Department of Information has been achieved and provides benefits for lecturers. Librarian, education staff, students, and institutions. The role of librarians and librarian collaboration with lecturers and students is a supporting factor in the successful implementation of the Informatic Open Library application.
Analyzing Information about a Hajj Pilgrimage in Indonesia in the Rare Newspaper Collection of The National Library of Indonesia
Authors: Supratman Frial Ramadhan
Published: October 2020

Background of the study: Indonesia is a country whose the largest number of Muslims in the world.  Every year, many Indonesian Muslims come to Mecca to perform hajj pilgrimage. In order to improve pilgrimage activity, Government and society need exact information about that. The librarian can take an important role in order to supply information about hajj pilgrimage.Purpose: The aim of research is explaining description and information about Indonesian hajj pilgrims through a collection of rare newspapers in the National Library of Indonesia.Method: The method used in this research is a descriptive research method. Author analyzes twenty two newspapers in National Library. Having been analyzed, the information obtained is interpreted by historical approach.Findings: The result of this research is that the author finds out 22 newspapers which contains information of hajj pilgrims. The information is qualitative data on the amount of hajj pilgrims and ships, the expense of hajj pilgrimage, the experience of hajj pilgrims, the problem faced by hajj pilgrims and government policy in controlling hajj pilgrims.Conclusion: In this paper, the author argues that rare newspaper collection contains many information about the activity of the hajj pilgrimage during Dutch colonial period.
Mitochondrial Dysfunction Accelerates Ageing
Authors: Schroth Johannes , Henson Sian M.
Published: October 2020

We review here the seminal findings of Desdin-Mico et al. showing that T cells with dysfunctional mitochondria induce multimorbity and premature senescence, due to mitochondrial transcription factor A (TFAM). They add further weight to the idea that targeting immunometabolism could be beneficial in combating the detrimental effects of age-related disease.
Deep Learning Driven Automated Detection of COVID-19 from Radiography Images: A Comparative Analysis
Authors: Rahman Sejuti , Sarker Sujan , Al Miraj Abdullah , Amin Nihal Ragib , Haque A. K. M. Nadimul , Al Noman Abdullah
Published: October 2020

The COVID-19 pandemic has wreaked havoc on the whole world, taking over half a million lives and capsizing the world economy in unprecedented magnitudes. With the world scampering for a vaccine, early detection and containment is the only redress. Existing diagnostic technologies with high accuracy like RT-PCRs are expensive and sophisticated, requiring skilled individuals for specimen collection and screening, resulting in lower outreach. So, methods excluding direct human intervention are much sought after, and artificial intelligence-driven automated diagnosis, especially with radiography images, captured the researchers' interest. This survey marks a detailed inspection of the deep-learning-based automated detection of COVID-19 works done to date, a comparison of the available datasets, methodical challenges like imbalanced datasets, and others, along with probable solutions with different pre-processing methods, and scopes of future exploration in this arena. We also benchmarked the performance of 315 deep models in diagnosing COVID-19, Normal, and Pneumonia from x-ray images of a custom dataset created from four others. The dataset is publicly available at https://github.com/rgbnihal2/COVID-19-X-ray-Dataset. Our results show that DenseNet201 model with Quadratic SVM classifier performs the best (accuracy: 98.16%, sensitivity: 98.93%, specificity: 98.77%) and maintains high accuracies in other similar architectures as well. This proves that even though radiography images might not be conclusive for radiologists, but it is so for deep learning algorithms for detecting COVID-19. We hope this extensive review will provide a comprehensive guideline for researchers in this field.
Pseudo-Spatially-Distributed Modeling of Water Balance Components in the Free State of Saxony
Authors: Luong Thanh Thi , Poeschmann Judith , Vorobevskii Ivan , Wiemann Stefan , Kronenberg Rico , Bernhofer Christian
Published: October 2020

Highly-resolved data on water balance components (like runoff or storage) are crucial to improve water management, e.g., in drought or flood situations. Because regional observations of these components cannot be acquired adequately, applying water balance models is a feasible solution. We developed an innovative approach using the physically-based lumped-parameter water balance model BROOK90 (R version) integrated into a sensor network platform to derive daily water budget components for catchments in the Free State of Saxony. The model is not calibrated but rather uses available information on soil, land use and precipitation only. We applied the hydro response units (HRUs) approach for 6175 small and medium-sized catchments. For the evaluation, model output was cross-evaluated in ten selected head catchments in a low mountain range in Saxony. The mean values of Kling-Gupta efficiency (KGE) for the period 2005-2019 to these catchments are 0.63 and 0.75 for daily and monthly discharge simulations, respectively. The simulated evapotranspiration and soil wetness are in good agreement with the SMAP_L4_GPH product in April 2015-2018. The study can be enhanced by using different data platforms as well as available information on study sites.
Management of Laryngopharyngeal Reflux: A Practical Algorithm Management for Primary care Physicians
Authors: Lechien Jerome R , Saussez Sven , Muls Vinciane , Barillari Maria R , Chiesa-Estomba Carlos M. , Hans Stephane , Karkos Petros
Published: October 2020

Laryngopharyngeal reflux (LPR) is a prevalent disease in the general population and may have acute or chronic clinical presentation. LPR may be misdiagnosed in primary care medicine regarding the lack of gastroesophageal reflux disease symptoms and the lack of findings at the gastrointestinal endoscopy. Depending on the physician field of expertise and experience, LPR may be clinically over- or under-diagnosed. The management of LPR is possible in primary care medicine but primary care physician has to consider some red flags that requires to address the patient to otolaryngologist or gastroenterologist. The use of patient-reported outcome questionnaire such as reflux symptom score-12 and the consideration of some oral and pharyngeal findings visualized through the mouth opening may help the primary care physician to evaluate the LPR findings at the diagnosis time and throughout treatment. In this review, we provide a practical algorithm of management of LPR for primary care physician or other specialists that cannot perform fiberoptic examination. In this algorithm, physician has to exclude some confounding conditions such as allergy or other causes of pharyngolaryngitis and red flags. Physician may prescribe an empirical treatment based on diet and behavioral changes with or without medication, depending on the complaint severity of the patient. In case of prescription of medication, proton pump inhibitors and alginate have to be considered in association to protect the upper aerodigestive tract mucosa from acid, weakly acid and alkaline pharyngeal reflux events.
Epigenetics of Muscle- and Brain-Specific Expression of KLHL Family Genes
Authors: Ehrlich Kenneth , Baribault Carl , Ehrlich Melanie
Published: October 2020

KLHL genes and the related KBTBD genes encode components of the Cullin-E3 ubiquitin ligase complex and typically target tissue-specific proteins for degradation, thereby affecting differentiation, homeostasis, metabolism, cell signaling, and the oxidative stress response. Despite their importance in normal cell function and in disease (KLHL40, KLHL41, KBTBD13, KEAP1, and ENC1), previous studies that examined epigenetic factors affecting transcription were predominantly limited to promoter DNA methylation. Using diverse tissue and cell culture whole-genome profiles, we examined 17 KLHL or KBTBD genes preferentially expressed in skeletal muscle or brain to identify tissue-specific enhancer and promoter chromatin, open chromatin (DNaseI hypersensitivity), and DNA hypomethylation. Sixteen of the 17 genes displayed muscle- or brain-specific enhancer chromatin in their gene bodies, and most exhibited specific intergenic enhancer chromatin as well. Seven genes were embedded in a super-enhancer. The enhancer chromatin regions typically displayed foci of DNA hypomethylation at peaks of open chromatin. In addition, we found evidence that gene neighbors (HHATL and FBXO32) of KLHL40 and KLHL38 harbor enhancer chromatin that likely upregulates the adjacent KLHL gene. Many KLHL/KBTBD genes had tissue-specific promoter chromatin at their 5’ ends, but surprisingly, two (KBTBD11 and KLHL31) had constitutively unmethylated promoter chromatin in their 3’ exons that overlaps a retrotransposed KLHL gene. Our findings demonstrate the importance of expanding epigenetic analyses beyond the 5’ ends of genes in studies of normal and abnormal gene regulation.
Feasibility of the Schizophrenia Hope Scale-9: A psychometric study
Authors: Choe Kwisoon , Ryu Eunjung , Kim Sunghee
Published: October 2020

Hope is important in the rehabilitation of persons with schizophrenia, through scales to measure hope are not appropriate for this population. The purpose of this cross-sectional study was to identify the psychometric properties of the Schizophrenia Hope Scale-9 (SHS-9) using data from 83 people with schizophrenia in four mental health centers and 762 healthy persons from two universities in South Korea. The mean (standard deviation) SHS-9 score of the participants with schizophrenia and healthy participants was 11.24 (4.90) and 14.83 (3.10), respectively. Lower scores indicate a lower level of hope. The internal consistency alpha coefficient was 0.92 with a 4-week test-retest reliability of 0.89. Criterion-related construct validity was established by examining the correlation between the SHS-9 and the State-Trait Hope Inventory scores. Divergent validity was identified through a negative relationship of SHS-9 with the Beck Hopelessness Scale. The construct validity of the SHS-9 was confirmed through principal component analysis with extraction methods, which resulted in a one-factor solution, accounting for 49–60% of the total item variance.. This study provided evidence for the validity and reliability of the SHS-9; therefore, it could be used to measure hope in people with schizophrenia.
Evaluation of Reference Genes for qRT-PCR Normalization in Angelica decursiva under Various Experimental Conditions
Authors: He Yuedong , Zhong Yuan , Bao Zhenzhen , Wang Weiqi , Xu Xiaoqing , Gai Yanan , Wu Jie
Published: October 2020

Angelica decursiva is one of the lending traditional Chinese medicinal plants producing coumarins. Notably, several studies have focused on the biosynthesis and not the qRT-PCR (quantitative real-time reverse transcription polymerase chain reaction) study of coumarins. This qRT-PCR technique has been extensively used to investigate gene expression levels in plants and the selection of reference genes which plays a crucial role in standardizing the data form the qRT-PCR analysis. In our study, 11 candidate reference genes were selected from the existing transcriptome data of Angelica decursiva. Here, four different types of statistical algorithms (geNorm, NormFinder, BestKeeper, and Delta Ct) were used to calculate and evaluate the stability of gene expression under different external treatments. Subsequently, RefFinder analysis was used to determine the geometric average of each candidate gene ranking, and to perform comprehensive index ranking. The obtained results showed that among all the 11 candidate reference genes, SAND family protein (SAND), protein phosphatase 2A gene (PP2A), and polypyrimidine tract-binding protein (PTBP) were the most stable reference genes, where Nuclear cap binding protein 2 (NCBP2), TIP41-like protein (TIP41), and Beta-6-tubulin (TUBA) were the least stable genes. To the best of our knowledge, this work is the first to evaluate the stability of reference genes in the Angelica decursiva which has provided an important foundation on the use of qRT-PCR for an accurate and far-reaching gene expression analysis in this medicinal plant.
Mycoplasmosis: a case report
Authors:   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Pavlova E.B. , Pavlova N.V. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Timchenko V.N. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Chernova T.M. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Bulina O.V. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Kalugina A.O. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Shapovalenko A.M. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation
Published: October 2020

Mycoplasma infections are very common among children and have multiple clinical forms. These infections can be associated with severe pathological conditions, in particular with allergic dermatosis. We report a case of mycoplasmosis with multiple severe lesions of the mucous membranes of an allergic nature, which required differential diagnosis with Stevens-Johnson syndrome. Timely diagnosis of Mycoplasma infections and identification of risk factors for severe disease require detailed analysis of clinical data and the use of appropriate laboratory methods. Rational comprehensive therapy with macrolides ensures favorable course of the disease. Key words: allergic dermatosis, children, Mycoplasma infection
Actual Issues of the Cardiac Complications Risk Assessment and Correction in Non-Cardiac Surgery
Authors: Sumin A. N.
Published: October 2020

Worldwide, more than 200 million non-cardiac surgeries are performed annually, and this number is constantly increasing; cardiac complications are the leading cause of death in such surgeries. So, in a multicenter study conducted in 27 countries, cardiovascular complications were present in 68% of cases of death in the postoperative period. Registers of recent years have shown that the number of such complications remains high, for example, with a dynamic assessment of troponins, perioperative myocardial damage was detected in 13-18% of cases. This review provides a critical analysis of the step-by-step algorithm for assessing cardiac risk of non-cardiac operations considering the emergence of new publications on this topic. The review discusses new data on risk assessment scales, functional state assessment, the use of non-invasive tests, biomarkers, the role of preventive myocardial revascularization in the preoperative period, and drug therapy. The issues of non-cardiac operations after percutaneous coronary intervention, perioperative myocardial damage are considered separately. The review emphasizes the difficulties in obtaining evidence, conducting randomized clinical trials in this section of medicine, which do not allow obtaining unambiguous conclusions in most cases and lead to inconsistencies and ambiguities in the recommendations of various expert groups. This review will help practitioners navigate this issue and help to use the optimal diagnostic and treatment strategy before performing non-cardiac surgery.
Management and Outcome of a Complex Medial Tibial Plateau Fracture
Authors: Kumar Deepak , Sodavarapu Praveen , Aggarwal Aditya , Hooda Aman , Sajid Mohammad
Published: October 2020

Case:

A 26-year-old patient who had a road traffic accident sustained a complex knee injury, which resulted in a comminuted fracture of the medial tibial plateau, along with undisplaced lateral collateral ligament (LCL) avulsion that was managed surgically with rim plating, resulting in a good outcome after 1-year follow-up

Conclusion:

The authors present a rare case of a combination of axial loading and varus injury to the knee, which caused splaying of the medial tibial plateau with an undisplaced LCL avulsion, managed with single rim plating, which is a relatively new method of fixation that obviated the need for 2 separate implants, with good functional outcome.
Deep-Learning-Based Vuggy Facies Identification from Borehole Images
Authors: Jiang Jiajun , Xu Rui , James Scott C. , Xu Chicheng
Published: October 2020

Identification of vuggy intervals and understanding their connectivity are critical for predicting carbonate reservoir performance. Although core samples and conventional well logs have been traditionally used to classify vuggy facies, this process is labor intensive and often suffers from data inadequacies. Recently, convolutional neural network (CNN) algorithms have approached human-level performance at multiimage classification and identification tasks. In this study, CNNs were trained to identify vuggy facies from a well in the Arbuckle Group in Kansas, USA. Borehole-resistivity images were preprocessed into half-foot intervals; this complete data set was culled by removing poor-quality images to generate a cleaned data set for comparison. Core descriptions along with conventional gamma ray, neutron/density porosity, photoelectric factor (PEF), and nuclear magnetic resonance (NMR) T2 data were used to label these data sets for supervised learning. Hyperparameters defining the CNN network size (numbers of convolutional layers/filters and the numbers of fully connected layers/neurons) and minimize overfitting (dropout rates, patience, and minimum delta) were optimized. The median losses and accuracies from five Monte Carlo realizations of each hyperparameter combination were the metrics defining CNN performance. After hyperparameter optimization, median accuracy for vuggy/nonvuggy facies classification was 0.847 for the cleaned data set (0.813 for the complete data set). This study demonstrated the effectiveness of using microresistivity image logs in a CNN to classify facies as either vuggy or nonvuggy, while highlighting the importance of data quality control. This effort lays the foundation for developing CNNs to segment images to estimate vuggy porosity.
Relationship Between Incremental Glucose Peak and Diabetic Retinopathy in Tertiary Hospital: Liaoning Diabetic Microvascular Complications Study (LD-MCS)
Authors: Li Xiang , Yao Litong , Wang Xinyu , Zhong Yifan , Wang Yan , Wu Jingyang , Geng Jin , Zhou Yun , Zhang Jiahua , Chen Jun , Xu Yingying , Chen Lei , Liu Lei , Hu Yudong
Published: October 2020

Background: Glucose variability may contribute to macrovascular complications of diabetes but evidence for its association with diabetic retinopathy (DR) is limited. This study is aimed to investigate the correlation between incremental glucose peak (IGP) and diabetic retinopathy (DR) in Chinese population with type 2 diabetes.Methods: A hospital-registry, case-control study collecting data from Liaoning Diabetic Microvascular Complications Study (LD-MCS) during 2012-2018. 795 adults with DR were included and matched with two diabetic controls per case (n = 1590) by gender and age. IGP was defined as the peak minus baseline plasma glucose value during 5-point oral glucose tolerance test (OGTT). DR was diagnosed by two-field fundus photographs under Early Treatment Diabetic Retinopathy Study criteria and stratified into mild non-proliferative DR (NPDR), moderate NPDR, and vision-threatening DR (VTDR). Logistic regression analysis was applied to determine the relationships.Results: Among 2385 participants (age, 58.40±11.52 years; 57.11% men), higher IGP was independently associated with the presence of any DR (odds ratio [OR], 1.05; 95% confidence interval [CI], 1.02-1.07; P < 0.001), moderate NPDR (OR, 1.06; 95% CI, 1.01-1.12; P = 0.020) and VTDR (OR, 1.13; 95% CI, 1.07-1.19; P < 0.001), respectively. Moreover, estimated ratio for any DR and VTDR from low-quartile IPG increased by 1.33 (95% CI, 1.04-1.70; P for trend = 0.021) and 3.64 (95% CI, 1.97-6.72; P for trend < 0.001), respectively.Conclusions: OGTT-derived IGP was independently associated with DR severity scales in Chinese patients with type 2 diabetes. More attention by health care personnel needs to be paid to glucose variability of this population.
Is the Willingness and Ability of Nurses to Respond to Various Disasters the Same? A Cross-Sectional Study in Iran
Authors: Moradi Maryam , Sharififar Simintaj , Shokouh Seyyed- Javad Hosseini
Published: October 2020

Background: Healthcare centers, as the primary organizations involved in the occurrence of unexpected events, require to identify significant and influential motivational factors in the creation of willingness and, consequently, the ability of health personnel and staff (nurses) to respond to critical situations as the main organizational assets. This study was designed with the aim to determine the factors affecting the willingness and ability of nurses to deal with various disasters in Tehran hospitals.Methods: This research is a cross-sectional study. The instrument used is a researcher-made questionnaire, which consists of three parts of demographic information, evaluation of the level of nurses' willingness and ability to respond to various disasters, and obstacles to continuing to work in disasters.Results: A total of 308 questionnaires were completed. 39.3% of participants were female, and 60.7% of them were male. The level of willingness and ability of participants to continue working in crisis indicates that the highest willingness and ability are associated with natural disasters (floods, earthquakes), and the lowest willingness and ability are related to participating in response to the disease epidemic. The prioritization of the participants in this study in connection with the most critical barriers to responding to the crisis demonstrated that caring for children in natural disasters and Mass Casualty Incident, concern for family health in chemical disasters, fear of contamination in nuclear disasters, and fear of Infection in epidemic of diseases are among the most important obstacles. In examining the factors influencing the willingness and ability of research units to participate in disaster response raised, the factors of gender, age, marital status, and health level of individuals affected the level of willingness and ability of individuals. Besides, the components of income level, care for the elderly, and care for the disabled have only been influential on the willingness of people to participate in disaster response.Conclusion: The professional preparation of health care personnel to perform their duties in critical conditions is essential. Hence, preventive measures to minimize the risk and strengthen the ethical obligations of employees in this profession in crises will be beneficial.
Host metabolite-cytokine correlation landscape in SARS-CoV-2 infection
Authors: Xiao Nan , Nie Meng , Pang Huanhuan , Wang Bohong , Hu Jieli , Meng Xiangjun , Li Ke , Ran Xiaorong , Long Quanxin , Deng Haijun , Tang Ni , Huang Ailong , Hu Zeping
Published: October 2020

The systemic cytokine release syndrome (CRS) is a major cause of the multi-organ injury and fatal outcome induced by SARS-CoV-2 infection in severe COVID-19 patients. It has been well-known that metabolism plays a role in modulating the immune responses in infectious diseases. Yet, how the host metabolism correlates with CRS in COVID-19 patients and how the perturbed metabolites affect the cytokine release remains unclear. Here, we performed both metabolomics and cytokine/chemokine profiling on serum samples from the same cohort of healthy controls, mild and severe COVID-19 patients and delineated the global metabolic and immune response landscape along disease progression. Intriguingly, the correlation analysis revealed the tight link between metabolites and proinflammatory cytokines and chemokines, such as IL-6, M-CSF, IL-1α, IL-1β, implying the potential regulatory role of arginine metabolism, tryptophan metabolism, and purine metabolism in hyperinflammation. Importantly, we demonstrated that targeting metabolism markedly modulated the proinflammatory cytokines release by PBMCs isolated from SARS-CoV-2-infected rhesus macaques ex vivo. Beyond providing a comprehensive resource of metabolism and immunology data of SARS-CoV-2 infection, our study showed that metabolic alterations can be potentially exploited to develop novel strategy for the treatment of fatal CRS in COVID-19.
Comparison of Stresses in Monoblock Tilted Implants and Conventional Angled Multiunit Abutment-implant Connection Systems in the All-on-four Procedure
Authors: Zincir Özge Özdal , Parlar Ateş
Published: October 2020

Background: The All-on-four dental implant method is an implantology method designed to provide a comfortable prosthetic treatment option by avoiding advanced surgical procedures. This research aims to compare and evaluate the stress and tension values in conventional angled multiunit abutment-implant connection systems and monoblock dental implants used in the all-on-four procedure with finite element analysis.Methods: Two master models were created by placing four implants connected to multiunit abutments (group A) in the interforaminal region of a completely edentulous mandible and four monoblock implants (group B) in the same region of another completely edentulous mandible. Group A implants were classified according to their diameter as follows: 3.5 mm (M1A), 4.0 mm (M2A), and 4.5 mm (M3A). Similarly, group B implants were classified as M1B, M2B, and M3B. In the six models rehabilitated with acrylic fixed prostheses, a 100 N force was applied to the anterior implant region, and a 250 N force was applied to the posterior cantilever in both axial and 30° oblique directions. Von Mises stresses were analyzed in the bone and implant regions of all models.Results: M1A and M1B, M2A and M2B, and M3A and M3B were compared with each other under axial and oblique forces. The maximum Von Mises stresses in the bone around implants and the prosthesis screws, and the maximum and minimum principal stresses in the cortical and trabecular bone in group A models were significantly higher than those in group B models.Conclusions: This study shows that the use of monoblock implants without abutment-implant connections can prevent bacterial accumulation in micro-gaps, but the biomechanical properties of this implant system should be improved.
Reported neighborhood traffic and the odds of asthma/asthma like symptoms: a cross-sectional analysis of a multi-racial cohort of children
Authors: Commodore Sarah , Ferguson Pamela , Neelon Brian , Newman Roger , Grobman William , Tita Alan , Pearce John , Bloom Michael , Svendsen Erik , Roberts James , Skupski Daniel , Sciscione Anthony , Palomares Kristy , Miller Rachel , Wapner Ronald , Vena John E , Hunt Kelly J
Published: October 2020

Background: Respiratory symptoms and asthma in children pose a significant clinical and public health burden. Our aim was to examine exposures to environmental air pollution in relation to asthma and related symptoms in a multi-racial cohort of children. Methods: We conducted a cross-sectional analysis evaluating the association between reported neighborhood traffic (a proxy for traffic-related air pollution) and asthma among 855 children aged 4 to 8 years old who participated in the Environmental Influences on Child Health Outcomes (ECHO) cohort. The primary outcome, asthma/asthma like symptoms (defined as current and/or past physician diagnosed asthma, past wheezing, or nighttime cough or wheezing in the past 12 months), was assessed by parental report via questionnaire. The relationship between the primary exposure and asthma/asthma like symptoms was examined using logistic regression. Results: The prevalence of asthma/asthma like symptoms was 23%. Fifteen percent of parents responded “Agree” or “Strongly Agree” to the question, “There is so much traffic along the streets that it makes it difficult or dangerous to walk with my child in my neighborhood” (n=129/855). Children whose parents had affirmed significant neighborhood traffic had a higher odds of having asthma/asthma like symptoms than children without significant neighborhood traffic [adjusted OR=1.78 (95% CI: 1.10, 2.88)] after controlling for child’s race-ethnicity, age, sex, maternal education level, family history of asthma, presence of play equipment in the home environment, public parks in the neighborhood and obesity. Other factors significantly associated with asthma/asthma like symptoms were: non-Hispanic Black and Hispanic race/ethnicity [OR=2.53 (95% CI: 1.43, 4.50)] and [OR=2.25 (95% CI: 1.28, 3.94), respectively, vs. non-Hispanic White referent], play equipment in the home environment or backyard [OR=1.60 (95% CI: 1.09, 2.35)], obese status [OR=2.54 (95% CI: 1.55, 4.17)], male sex [OR=1.53 (1.06, 2.22)] and family history of asthma [OR=3.19 (2.20, 4.64)]. Conclusions: Reported neighborhood traffic, non-Hispanic Black and Hispanic race/ethnicity, male sex, play equipment within the home environment, obesity, and family history of asthma were associated with greater odds for asthma/asthma like symptoms. Further characterization of neighborhood traffic patterns is needed, since many children live near this source of environmental air pollution and significant racial/ethnic disparities exist.
WITHDRAWN: Apolipoprotein E4 expressed by microglia impairs microglial functions and enhances neurotoxicity
Authors: Wang Na , Wei Min , Li Xinxiu , Jia Lin , Li Jianguo , Xu Huaxi , Zhang Yun-wu , Zheng Honghua
Published: October 2020

Background Microglia, the major cell type that mediates active immune defence in the central nervous system (CNS), constantly survey the brain parenchyma through highly motile processes. Mounting evidence has implicated both beneficial and toxic roles of microglia when over-activated upon neuronal injury. Understanding the function of microglia in the brain may uncover the regulatory mechanisms for neuroinflammation and facilitate the development of a novel therapeutic strategy for Alzheimer's disease (AD). The ε4 allele of apolipoprotein E (APOE) is a major genetic risk factor for the late onset AD. ApoE, as the major cholesterol carrier in the brain, has been implicated in AD pathogenesis. However, how APOE and APOE isoforms directly regulate microglial functions remains largely unknown. Methods Using primary culture of microglia from Apoe knockout (KO) mice, APOE3 and APOE4 targeted replacement (TR) mouse, we investigated the characteristics of microglial secreted apoE particles and the biological effects of apoE isoforms on microglial inflammatory response, migratory ability, cell viability and proliferation. Meanwhile, microglia-neuron co-culture system was utilized to study the effects of apoE isoforms on neurite outgrowth.Results Herein, we found that microglia secret abundant lipidated apoE. Interestingly, apoE4 particles from primary microglia exhibited a higher lipidation status compared to apoE3 particles. Furthermore, apoE4 microglia exhibited a reduced migratory ability as well as enhanced inflammatory responses and neurotoxicity, indicating microglial apoE4 is involved in unfavourable functions. Conclusions Our findings revealed the critical roles for apoE and apoE isoforms in regulating microglial functions. Our results also indicate that targeting apoE-mediated microglial inflammatory responses may serve as a potential therapeutic strategy for AD.
The study of inter-regional cooperation relations in ensuring the economic security of territories under the conditions of COVID-19
Authors:   Russian University of Economics  named after G. V. Plekhanov, Konovalova К. , Shumakova К. ,   Kabardino-Balkar state University named after  H. M. Berbekov, Shumakhov R. ,   North Caucasian Institute (branch)  of RANEPA
Published: October 2020

The purpose of the study is to identify the possibilities of forming interregional cooperation as an economic system on the example of the Stavropol region, with the need for a balance between the main parameters of assessing the economic security of the territory: regional specialization and industry diversification. The research shows that the tool for improving the competitiveness of economic sectors is interregional cooperation, assessed by the degree of formation of the sectoral structure of the regional economy and the dynamics of its change. The analysis of the organizational and economic mechanism of regional support for small and medium-sized businesses has revealed a number of advantages over large businesses in the context of the regional economy, including: reducing economic threats, strengthening the economic security of the region. It has been proved that support measures in the new conditions of business transformation, social inequality, and the consequences of COVID-19 should take into account the economic security level of the regions. The concept of “e-government”, which is the basis of the concept of e-government, represented by the information environment for the implementation of key functions of territorial management based on innovative
Features of snow accumulation and snow cover parameters оn the Elkon mountain rang
Authors:   Melnikov Permafrost Institute SB RAS, Kirillin A. , Zheleznyak M. ,   Melnikov Permafrost Institute SB RAS, Zhirkov A. ,   Melnikov Permafrost Institute SB RAS, Misailov I. ,   Melnikov Permafrost Institute SB RAS, Verkhoturov A. ,   Transbaikal State University, Sivtsev M. ,   Melnikov Permafrost Institute SB RAS
Published: October 2020

With the intensive industrial development of South Yakutia, in particular the Elkon mountain range, the natural environment is experiencing an enormous anthropogenic load. To assess the state of the natural environment, it is important to obtain information about its background state before the start of an intensive technogenic impact. Snow cover seems to be the optimal indicator of chemical pollution of atmospheric air and atmospheric precipitation, as it is one of the significant natural factors that form natural conditions. To take effective preventive measures to eliminate severe consequences, reliable data on the characteristics and conditions of snow cover formation are required. The object of research is the Elkon mountain range, located in the northern part of the Aldan-Stanovoy Upland. The subject is the peculiarities of the formation of snow cover in this region. The purpose of the study is to determine the main meteorological parameters and physical characteristics that affect the conditions for the formation of snow cover. A set of methods was used in the study, including snow survey and routine observations of snow parameters in key areas. As a result of the study, new data were obtained on the regional features of the formation of snow cover. The practical focus of the study is to improve the reliability of engineering-geological and geocryological mapping and forecasting environmental changes
Conceptual consideration of political, national and religious security in western political and philosophical science
Authors:   Far Eastern Higher Combined Arms Command School named after Marshal of the Soviet Union K.K.Rokossovsky, Kononov S. , Zhukov A. ,   Transbaikal State University, Romanova N. ,   Transbaikal State University
Published: October 2020

The article is devoted to the analysis of the security philosophy formation, the central concept of which is security, differently understood by different philosophical directions. The purpose of the study is the need to analyze the process of the security concept formation in the history of Western philosophy. To achieve the goal, a comparative analysis methodology was applied based on a cultural-historical approach associated with the procedures for analyzing philosophical texts on security issues. The novelty of the research is provided by the analysis of the evolution of ideas about security as a concept, the structure of which has expanded, gradually including the sphere of not only real, material, but also imaginable, spiritual security. The authors note that for a long time it was customary to talk about the phenomenon of security only in the aspect of substantiating the reasons for the unification of the population within the boundaries of state formations. However, under the influence of Christian ideology, security began to be understood as a person’s inner experience of his spiritual state. At the same time, the actualization of the concept of “unity” within the framework of the national states of the New Age led to the development of the idea of national security, the accumulation of knowledge about which served as the beginning of a wide range of ideas about economic, cultural, legal and personal security formation. Now security has been understood as a system of measures within which definitions of protection and preservation, the state and the local group, material goods and spiritual interests, real and imaginary danger are divided
Resilience indicators of Kuzbass in the context of the 2020 pandemic (based on expert interviews)
Authors:   Kemerovo State Universit, Matveeva Е. , Goosen E. ,   Kemerovo State Universit, Nikitenko S. ,   Federal Research Center of Coal and Coal Chemistry SB RAS, Mitin А. ,   Kemerovo State Universit
Published: October 2020

The article aims to determine the main indicators of the socio-economic and political resilience of a region during the global crisis caused by the COVID-19 pandemic to a first approximation. The study considers the case of Kemerovo Region – Kuzbass, a division of the Siberian Federal District. The object of the research was to study the phenomenon of resilience in the regional political process; the subject matter is the identification of indicators of social, economic and political resilience of Kemerovo Region – Kuzbass under the COVID-19 pandemic conditions. These resilience indicators have an impact not only on the stability of the region as a constituent entity of the Russian Federation, but also affect the public sentiment, which are not always positive. The main subject of the research and at the same time the source of information were the opinions of experts – political and social scientists, economists representing different areas of professional activity – business community, the media, the higher education system and non-profit organizations. In this study, the main research method was expert interviews. Moreover, an interdisciplinary approach applied was based on the synthesis of D. Chandler’s political resilience and the social concept of alternative forms of resilience (M. Kousis, M. Paschou, M. Giovannini), as well as the model of economic resilience by R. Martin and R. Sunley. The authors note that the concept of resilience, despite its active use in foreign science, has not yet received due attention in the study of internal political processes including the problems of regional development in the constituent entities of the Russian Federation. The article suggests the authors’ interpretation of the resilience concept and identifies four main indicators of resilience – economic, social, political and psychological ones. The study has found that representatives of medium and large business and the media are the respondents most satisfied with the current state of the region’s sustainability. Representatives of non-profit organizations and higher education system do not see any sustainability under the current conditions. It is concluded that further prospects for strengthening the stability of Kuzbass should be associated with the departure from the single-industry economy focused exclusively on the coal mining, and the development of civil society institutions