bluuebunny/crossref_metadata_2025 huggingface dataset:
Hoax narrative construction in the social space of rumbuk randu village in the Mahfud Ikhwan’s novel of Dawuk kisah kelabu dari rumbuk randu (2017)
Authors: Nurafia Rifa , Tjahjandari Lily
Published: August 2022

Hoax becomes a social phenomenon that is formed and formed. This description causes hoaxes to operate in the social space. In the novel Dawuk Kisah Kelabu Dari Rumbuk Randu by Mahfud Ikhwan, hoaxes show that there is a structured effort that leads opinion to provocation. Rural social space becomes a possible field with many differences in capital in society. In this article will explore how hoax strategies in text narratives show rural social spaces that function to defend one's position. This study aims to show social space as a place for hoaxe’s formation. The method used is descriptive analysis method with the theory of Arena Pierre Bourdieu. The findings show that social space is used as a place of defense for a hoax-spreading agent named Warto Kemplung by using provocative language. The social space became the place where Warto Kemplung changed positions to influence the people in the village of Rumbuk Randu. The strategy with the latest topic language and the use of responsive language shows a picture of the production of oral speech as a language capital owned by Warto Kemplung. The existence of Warto Kemplung also shows the existence of village spaces and coffee shops as arenas in society as free fields anyone fill to maintain a position.
Impacto de la educación virtual en los estudiantes de la UTP en tiempos de pandemia
Authors: Magallón Leyla , Ureña Mónica , Chang Juan , García Julio , Barría Nicole
Published: August 2022

El siguiente estudio fue realizado en la Universidad Tecnológica de Panamá Campus Víctor Levi Sasso, con el objetivo principal de examinar el nivel de estrés por el cual están pasando los estudiantes de esta casa de estudio, con la implementación de clases virtuales, durante el periodo de cuarentena a raíz de la pandemia causada por la COVID-19. Para el año 2020, esta sede de la universidad contaba con 15,232 estudiantes matriculados, de los cuales se encuestaron a 375, quienes pertenecen a las seis facultades que conforman la universidad. Los datos fueron analizados por medio del programa estadístico Minitab, y luego de obtener los resultados, logramos concluir que el nivel de estrés de los estudiantes si ha sido afectado por la implementación de las clases virtuales.
Diseño de un dispositivo para el monitoreo remoto no invasivo en pacientes con COVID-19, que se encuentren en aislamiento domiciliario
Authors: Fuentes Paola , González Pedro , Peña Lissette , Sáez Yessica
Published: August 2022

Durante los últimos meses, el mundo se ha visto afectado por el descubrimiento de un nuevo coronavirus llamado COVID-19, el cual produce síntomas leves o críticos en la salud de las personas que lo contraen. Debido a su facilidad de contagio, se ha convertido en una crisis de salud pública, donde Panamá no escapa de esta situación, siendo alarmante el incremento de contagios y fallecimientos diarios. La utilización de la tecnología en el área de la medicina beneficia no solo al paciente; si no también al personal sanitario encargado, permitiéndoles obtener datos más precisos de la evolución de las personas afectadas. A pesar de esto, no se ha encontrado en Panamá un dispositivo que ayude a los pacientes con COVID-19 que se encuentran en aislamiento domiciliario. Por esta razón, el objetivo de esta investigación se centra en el diseño de un dispositivo de monitoreo remoto que ayude al profesional de la salud a darle un mejor seguimiento a los pacientes positivos de COVID-19, que se encuentran en aislamiento domiciliario, evitando que el mayor número de pacientes ingresen a la sala de cuidado intensivos. El diseño propuesto utiliza biosensores que son colocados en diferentes zonas del cuerpo y, dependiendo del parámetro a sensar, se obtienen las señales que van a ser procesadas por un microcontrolador y posteriormente se envían al enrutador a través de su conexión a internet. Las simulaciones arrojaron resultados muy similares a los que se obtendrían de manera física. Se recomienda continuar con la investigación y realizar el prototipo físico para ayudar no solo a los pacientes con COVID-19 si no también a otros pacientes que necesiten monitoreo remoto de manera continua.
Prototipo de un sistema de monitoreo para paciente en aislamiento domiciliario por COVID19, utilizando Internet de las Cosas
Authors: Quintero Moisés , Miranda Carlos , Pérez Luiyiana
Published: August 2022

En este artículo se presenta los resultados del desarrollo de un prototipo de un sistema de monitoreo para pacientes en aislamiento domiciliario por covid19, utilizando internet de las cosas. Para el desarrollo del prototipo se utilizó una metodología en cascada e ingeniería de software, con un enfoque de investigación aplicada, que consistió en localizar un dispositivo, a través de acceso remoto SMS. El dispositivo consta de una antena GPS, una tarjeta SIM 808 alimentado por una tarjeta Arduino Uno. Se tiene una Raspberry pi conectado a un módulo SIM 900 que funciona como servidor, que envía un mensaje de texto al Arduino Uno conectado a modulo SIM 808 (cliente). El estudio consistió en validar la funcionalidad de la comunicación de los dispositivos y recoger los datos, que son almacenados en una base de datos en la nube, y mostrados en una aplicación web restringida por privilegio de usuario. Esta información muestra la localización del dispositivo, indicando su movilidad, a través de Google Maps, también se cuenta con un módulo de alerta, que envía notificaciones por correo, cuando el dispositivo sale del rango establecido, este prototipo tiene la finalidad de ser utilizado para paciente en aislamiento domiciliario, pero puede ser modificado para diferentes utilidades de geolocalización.
Abordagem STEAM no desenvolvimento de letramento estatístico: uma revisão de literatura
Authors: Appelt Veridiana Kelin , Maia Dennys Leite
Published: August 2022

O presente artigo é uma revisão da literatura realizada, na qual teve por objetivo identificar como são desenvolvidas práticas que visam o desenvolvimento do Letramento Estatístico por meio da Abordagem STEAM no Ensino Fundamental, bem como, analisar quais são as áreas dos professores envolvidos nessas práticas. Os dados, dos últimos cinco anos, foram coletados nas bases Google Acadêmico, Plataforma de Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), na Scientific Electronic Library Online (SciELO) e na Biblioteca Digital Brasileira de Teses e Dissertações (BDTD). Realizou-se descrição e análise das práticas, na qual os autores apontam que intervenções ancoradas na STEAM são relevantes para o desenvolvimento do letramento estatístico, favorecem a interdisciplinaridade, a aprendizagem por meio de investigação, a aprendizagem criativa e outras habilidades consideradas relevantes no Século XXI. Constatou-se que tais práticas preconizam a resolução de problemas reais ou de situações simuladas. Observou-se predominância de professores de Matemática nas práticas que fazem parceria com professores de séries iniciais e professores de Ciências.
Aspects of occupational aging according to elderly workers: old age, work, and worker health
Authors: Pazos Priscila de Freitas Bastos , Ferreira Aldo Pacheco
Published: August 2022

Population aging promotes meaningful changes in social structures, increasing the presence of older people in the labor market. By exposing this context, this research aims to analyze the following questions: the representation of work for older people, aging at work, and the relationship between the continuity of elderlies in the labor world and the worker's health. A semi-structured interview technique and a focus group with 16 elderly professionals were applied. Data were analyzed using a thematic content analysis technique. As analytical categories, it was highlighted the positive and negative aspects of the elderly at work, the representation of work for the elderly's lives and factors that affect the worker's health. The positive images of the elderly related to work were shown to be anchored to the experience and responsibility in face of work relationships. On the other hand, the negative view was mainly linked to the stigma of unproductivity. Working in old age was associated with income supplementation and personal development. The health of elderly people in work environments was mentioned as being affected by working organizations, including unfitted furniture and working hours, the lack of knowledge of new technologies, intergenerational conflicts and age discrimination. Therefore, it is demanded the development of public policies in order to reduce risk factors for working elderlies health.
Atuação do enfermeiro no cuidado ao paciente em quadro clínico de sepse: revisão integrativa
Authors: Moraes Vanessa Leopoldino de , Marcomini Emilli Karine , Martins Andressa Paola Oliveira Queiroz
Published: August 2022

A pesquisa tem por objetivo descrever a atuação do profissional enfermeiro ao paciente em quadro séptico, estabelecer fatores que contribuem para a ocorrência de sepse em UTI-adulto e identificar sinais e sintomas do paciente em sepse. Trata-se de uma revisão integrativa da literatura, realizada nas bases BDENF, LILACS, SCIELO e BVS. Foram utilizados os descritores: Enfermagem; Sepse; Unidades de Terapia Intensiva, incluíndo artigos originais, dentre os anos de 2010 a 2018. A busca troxe de forma geral protocolos, pesquisas de conhecimento dos enfermeiros, cuidados de enfermagem, sinais clínicos, fatores de risco, identificação de sinais e sintomas e processo de enfermagem. O papel do enfermeiro no contexto da assistência tange na aplicação de medidas de conforto condizentes com as condições clínicas do paciente, implementação de protocolos institucionais para nortear o cuidado, monitorização da assistência de toda a equipe envolvida e utilização do processo de enfermagem. Enfermeiros são profissionais de grande relevância no ambiente intensivo, desempenhando a função de impedir ou reduzir consideravelmente a progressão de sepse para as formas mais graves.
Induced arthritis, hepatocytes cytotoxicity and non-steroidal anti-inflammatory drugs (NSAIDs) – experimental study
Authors: Morsoleto Felipe Misael da Silva , Werneck Pedro Rondon , Moreira Juliana Aparecida Ramiro , Bomfim Fernando Russo Costa do , Esquisatto Marcelo Augusto Marretto , Morsoleto Maria Jose Misael da Silva
Published: August 2022

This study aimed to histologically evaluate the pharmacological activity of meloxicam, COX-2 inhibitor, on liver function in arthritic rats. Meloxicam is a non-steroidal anti-inflammatory drug (NSAID), COX-2 inhibitor, generally prescribed in the area of rheumatology. Thus, 18 Wistar rats were divided into 3 groups with 6 animals each: G1 (Negative Control), G2 (Arthritis induced with Zymosan [Zy]), G3 (Arthritis induced with Zymosan [Zy] and treated with meloxicam). The G3 treatment started on the 21st day after induction. The animals were sacrificed, by overdose of Ketamine/Xylazine, seven, 14 and 21 days after the beginning of the meloxicam treatment. Liver samples were collected from the animals, fixed in Millonig buffer containing 10% formaldehyde and processed for conventional histological analysis. G1 animals showed absence of inflammation and degeneration of hepatocytes. In the G2 group, a slight cytoplasmic alteration was observed at seven and 14 days. At 21 days, intense cytoplasmic and nuclear disorganization was detected, accompanied by cell necrosis. In G3, large spacing between sinusoid capillaries was detected. In some 14-day-old animals, amyloidosis was observed, with the presence of a large number of vacuolated hepatocytes involved in an amorphous mass of necrotic cells. Most of the hepatocyte nuclei had compacted chromatin, evidencing cellular degeneration. Meloxican, used as an anti-inflammatory in the synovial region, showed that, in addition to its beneficial effects for the treatment of rheumatological diseases, it is capable of, when administered orally, promoting a high level of liver damage.
Caracterização da pesquisa numa instituição brasileira de educação, ciência e tecnologia: trajetória e predominância de áreas temáticas
Authors: Silva Anderson Almeida , Santos Eliane Macedo Sobrinho , Neiva Ricardo Jardim , Santos Hércules Otacílio
Published: August 2022

O estudo destina-se a retratar, por meio de pesquisa descritiva em análise documental, a produção científica do Campus Araçuaí do Instituto Federal do Norte de Minas Gerais-IFNMG, no interstício de 2014 a 2020. No período, realizou-se um mapeamento dos projetos de pesquisa desenvolvidos no campus por intermédio de editais de apoio e forma voluntária, e procedeu-se a caracterização e análise. As análises foram norteadas pelos seguintes quesitos: Quantitativo e oscilações de projetos de pesquisa, das diferentes áreas temáticas; Tipos de pesquisa; Contribuições do gênero para a pesquisa; Nível de qualificação dos pesquisadores; Matriz de Forças, Fraquezas, Oportunidades e Ameaças na Pesquisa do IFNMG – Campus Araçuaí de acordo com as áreas temáticas. Como resultados, percebe-se uma inclinação da produção concentrada em subáreas das ciências humanas, bem como das ciências agrárias. Da análise, conclui-se que há a necessidade de adequação dos esforços de pesquisa do campus e pluralidade de áreas de conhecimento da formação do corpo docente, além de proximidade com especificidades regionais. Faz-se míster ampliar a divulgação da produção científica local nas ditas áreas de conhecimento, ajustadas ao Plano de Desenvolvimento Institucional (PDI) do campus e dados para discussão de políticas públicas e desenvolvimento regional.
O impacto da cirurgia bariátrica nas comorbidades: assistência de enfermagem ao paciente bariátrico
Authors: Santos Thafaela Rodrigues dos , Sousa Beatriz dos Reis , Anjos Mayara da Silva dos , Silva Thaís Rodrigues de Sousa , Morais Izabela Maria de Oliveira , Porto Maria Eduarda Moreira , Braga Aécio Assunção , Silva Arannadia Barbosa da
Published: August 2022

Obesidade é considerada uma doença caracterizada pelo acúmulo de gordura no organismo, esta situação pode desencadear ou até mesmo agravar morbidades como diabetes, dislipidemias e doenças cardíacas. Nesse sentido a cirurgia bariátrica é uma técnica utilizada na medicina a fim de promover a redução de peso em indivíduos que apresentam excesso de gordura corporal tendo comorbidades associadas ou não. A abordagem promove a diminuição da taxa de gordura no organismo, dessa forma, influencia diretamente no controle de doenças crônicas, sobretudo diabetes melito tipo 2 (DM2), dislipidemias e doenças cardiovasculares, pois a diminuição da circunferência abdominal impacta na sensibilidade da insulina, no processo de oxidação de ácido graxos e lipídios, promovendo assim maior qualidade de vida ao paciente. Entretanto, apesar da abordagem cirúrgica promover vários benefícios ao indivíduo, situações como hipovitaminose em função da baixa absorção de nutrientes são evidentes e podem influenciar fortemente na qualidade de vida do paciente. Por este motivo a participação de uma equipe multidisciplinar é indispensável no acompanhamento, sobretudo do enfermeiro, tendo em vista seu papel fundamental na orientação e elaboração de estratégias que possa promover o comprometimento e aderência do paciente ao tratamento. Com base nisso, este estudo tem como objetivo esclarecer a forma que a cirurgia bariátrica influência no metabolismo do individuo como alternativa para controlar ou ate mesmo reverter à sintomatologia das comorbidades e mostrar a influência do enfermeiro no processo.
Reutilização de cama de aviário compostada na produção e no crescimento inicial de mudas de eucalipto
Authors: Thomazini Soraya Carmelita Novaes , Souza José Antônio Rodrigues , Moreira Debora Astoni , Gonçalves Janine Mesquita
Published: August 2022

A cama de aviário, é oriundo da produção aviária, que se não tratado de maneira adequada pode impactar negativamente o ambiente. Objetivou-se obter um substrato com cama de aviário compostada para oferecer uma alternativa a produção e crescimento de Eucalyptus camaldulensis. Esse material foi compostado e caracterizado quanto ao teor de macronutrientes, sendo utilizados nos dois ensaios experimentais: germinação de sementes e crescimento inicial das mudas de Eucalyptus camaldulensis. As sementes foram plantadas e preenchidas com substrato comercial e diferentes percentuais de camas de aviários compostadas, cujo tratamento controle foi o substrato a base de casca de pinus e vermiculita. Forneceu-se 100% e 200% da dose de nitrogênio recomendada para a cultura, tendo como tratamento controle vasos preenchidos com solo do cerrado e adubação mineral de modo a fornecer 25g de N/planta. Para o experimento de crescimento inicial utilizou-se o Delineamento Inteiramente Casualizado (DIC) com os tratamentos distribuídos em esquema fatorial 4x2x17 (4 tratamentos, 2 doses de nitrogênio e tempo). Essas apresentaram maiores teores de nitrogênio quanto maior foi número de lotes de aves alojadas sobre a mesma cama. As sementes tiveram germinação tardia para os tratamentos com camas de aviários nas proporções de 20% e 50% e as mudas não sobreviveram. Nos tratamentos com 100% com camas de aviários não houve germinação. O melhor tratamento foi a cama de aviário compostada com maior número de reutilizações e com 100% da dose de nitrogênio. Todas as mudas apresentaram bons índices de IQD indicando chance de sobrevivência no campo.
O sofrimento do médico frente ao óbito do paciente: uma revisão integrativa
Authors: Destro Claudinei , Destro Cleonilce Rodrigues de Souza , Destro Lucas Rodrigues de Souza , Silva Rose Mary Costa Rosa Andrade , Pereira Eliane Ramos
Published: August 2022

Objetivo: Analisar na literatura científica as evidências publicadas sobre o sofrimento do profissional médico frente ao óbito do paciente. Método: Foi realizada uma revisão integrativa da literatura científica publicada nas bases de dados Pubmed, Scielo, Lilacs, Cinahl, Scopus e Web of Science. A busca foi norteada pela pergunta de pesquisa: Quais as evidências científicas sobre o sofrimento do médico frente ao óbito do paciente em ambiente hospitalar? A busca foi realizada nos meses de junho e julho de 2022. Foram incluídos os artigos científicos publicados entre os anos de 2017 até 2022. Resultados: Foram selecionados sete artigos com desenhos metodológicos variados relatando o sentimento do médico frente ao óbito do paciente, suas consequências e mecanismos de enfrentamento. Conclusão: O sofrimento do médico frente ao óbito do paciente está presente tendo consequências variadas e sendo necessário maior treinamento deste profissional, bem como mais estudos para a avaliação dos variados aspectos e mecanismos de enfrentamento.
Peran Inovasi, Kolaborasi dan Media Sosial terhadap Kinerja Usaha UMKM di DKI Jakarta
Authors: Deviastri Lily , Annisa Intan Tri
Published: August 2022

Merujuk pada teori Resource Based View, tujuan penelitian ini adalah untuk mengetahui kinerja usaha pada UKM di wilayah DKI Jakarta yang mengalami penurunan penjualan. Penelitian ini  dianalisa dengan metode regresi linier berganda. Sampel yang dugunakan adalah UKM binaan Dinas PPAPP DKI Jakarta sebanyak 72 responden dengan non probability sampling metode purposive sampling. Hasil yang diperoleh menunjukkan bahwa dari tiga variabel yang diangkat, yaitu inovasi, kolaborasi dan media sosial, variabel inovasi satu-satunya yang memiliki perngaruh positif dan signifikan terhadap kinerja usaha. Sehingga UKM perlu untuk mulai membiasakan diri mengelola system informasi secara inovatif di dalam organisasinya, tidak boleh takut berkolaborasi dengan pihak-pihak terkait, dan senantiasa meningkatkan komunikasi yang informatif di sosial media.Abstrak berupa ringkasan/sari artikel ilmiah yang terdiri dari tujuan, fenomena masalah, data dan metode, temuan/hasil analisis, konklusi dan implikasi manajerial.
Complanatuside alleviates inflammatory cell damage induced by pro-inflammatory cytokines in skin keratinocytes
Authors: Wang Xiao , Xu Xuetao , Wu Panpan , Wu Mengshuo , Gan Lishe , Jin Jingwei , Wu Rihui , Liu Wenfeng , Zhang Kun , Li Dongli , Zheng Xi
Published: August 2022

Cytokine-mediated inflammatory response is considered a cause of skin lesion in COVID-19 patients. Complanatuside is a flavonol glycoside isolated from Astragalus complanatus. Flavonoids from Astragalus complanatus were reported to have anti-inflammatory and anticancer activities but the potential protective effect of complanatuside on cytokine-induced inflammatory damage in skin keratinocytes is not known. The aim of this study is to explore the inhibitory effect of complanatuside on inflammation and its underlying mechanisms in skin epithelial HaCaT cells treated with inflammatory cytokines. The combination of IFN-γ, TNF-α, and IL-6 decreased cell viability, increased cell death, and pyroptosis in HaCaT cells. Treatment with complanatuside alleviated the effects of the cytokine combination on HaCaT cells. Complanatuside down-regulated pyroptosis related to NLRP3, GSDMD, and ASC. The effects of complanatuside were related to vast reductions in the levels of iNOS, COX-2, and ROS. Results of the present study indicate that complanatuside inhibited inflammation and protected the cells from inflammatory cell damage in HaCaT cells treated with the combination of IFN-γ, TNF-α, and IL-6. Complanatuside may be a promising candidate for inhibiting COVID-19 related skin inflammatory damage.
Engineered interfaces between perovskite La2/3xLi3xTiO3 electrolyte and Li metal for solid-state batteries
Authors: Yan Shuo , Al-Salih Hilal , Yim Chae-Ho , Merati Ali , Baranova Elena A. , Weck Arnaud , Abu-Lebdeh Yaser
Published: August 2022

Perovskite La2/3xLi3xTiO3 (LLTO) materials are promising solid-state electrolytes for lithium metal batteries (LMBs) due to their intrinsic fire-resistance, high bulk ionic conductivity, and wide electrochemical window. However, their commercialization is hampered by high interfacial resistance, dendrite formation, and instability against Li metal. To address these challenges, we first prepared highly dense LLTO pellets with enhanced microstructure and high bulk ionic conductivity of 2.1×10−4 S cm−1 at room temperature. Then, the LLTO pellets were coated with three polymer-based interfacial layers, including pure (polyethylene oxide) (PEO), dry polymer electrolyte of PEO-LITFSI (lithium bis (trifluoromethanesulfonyl) imide) (PL), and gel PEO-LiTFSI-SN (succinonitrile) (PLS). It is found that each layer has impacted the interface differently; the soft PLS gel layer significantly reduced the total resistance of LLTO to a low value of 84.88 Ω cm−2. Interestingly, PLS layer has shown excellent ionic conductivity but performs inferior in symmetric Li cells. On the other hand, the PL layer significantly reduces lithium nucleation overpotential and shows a stable voltage profile after 20 cycles without any sign of Li dendrite formation. This work demonstrates that LLTO electrolytes with denser microstructure could reduce the interfacial resistance and when combined with polymeric interfaces show improved chemical stability against Li metal.
Revisiting the 4 R’s: Improving post-release outcomes for rescued mammalian wildlife by fostering behavioral competence during rehabilitation
Authors: Goldenberg Shifra Z. , Parker Jenna M. , Chege Stephen M. , Greggor Alison L. , Hunt Matt , Lamberski Nadine , Leigh Kellie A. , Nollens Hendrik H. , Ruppert Kirstie A. , Thouless Chris , Wittemyer George , Owen Megan A.
Published: August 2022

Rescue, rehabilitation, and release (‘rescue-rehab-release’) of wildlife is an increasingly widespread practice across ecosystems, largely driven by habitat loss, wildlife exploitation and a changing climate. Despite this, its conservation value has not been realized, in part due to the scarcity of what has been termed “the 4th R”, research. Similar to conservation breeding and headstarting, rescue and rehabilitation entails close association of humans and the wildlife in their care over impressionable and extended periods. However, unlike these interventions, rescue and rehabilitation require an initial, and sometimes sustained, focus on crisis management and veterinary needs which can impede the development of natural behaviors and promote habituation to humans, both of which can compromise post-release survival and recruitment. In this perspective, we discuss the pathways toward, and implications of, behavioral incompetence and highlight opportunities for testable interventions to curtail negative outcomes post-release, without compromising the health or welfare of rescued individuals. We propose that practitioners ‘switch gears’ from triage to fostering behavioral competence as early in the rehabilitation process as is possible, and that research be implemented in order to develop an evidence-base for best practices that can be shared amongst practitioners. We focus on four mammalian species to illustrate specific contexts and considerations for fostering behavioral competence by building on research in the conservation translocation literature. Finally, we discuss a way forward that calls for greater cross-pollination among translocation scenarios involving extended time under human care during developmentally sensitive periods.
Exploration of cerebral hemodynamic pathways through which large artery function affects neurovascular coupling in young women
Authors: Cilhoroz Burak T. , DeBlois Jacob P. , Lefferts Wesley K. , Keller Allison P. , Pagan Lassalle Patricia , Meyer Michelle L. , Stoner Lee , Heffernan Kevin S.
Published: August 2022

Background

The interactions between large artery function and neurovascular coupling (NVC) are emerging as important contributors to cognitive health. Women are disproportionally affected by Alzheimer's disease and related dementia later in life. Understanding large artery correlates of NVC in young women may help with preservation of cognitive health with advancing age.

Purpose

To explore the association between large artery function, NVC and cognitive performance in young women.

Methods

Vascular measurements were made in 61 women (21 ± 4 yrs) at rest and during a cognitive challenge (Stroop task). Transcranial Doppler was used to measure left middle cerebral artery (MCA) maximum velocity (Vmax), mean velocity (Vmean), and pulsatility index (PI). NVC was determined as MCA blood velocity reactivity to the Stroop task. Large artery function was determined using carotid-femoral pulse wave velocity (cfPWV) as a proxy measure of aortic stiffness and carotid ultrasound-derived measures of compliance and reactivity (diameter change to the Stroop task). Cognitive function was assessed separately using a computerized neurocognitive battery that included appraisal of response speed, executive function, information processing efficiency, memory, attention/concentration, and impulsivity.

Results

MCA Vmax reactivity was positively associated with executive function (β = 0.26, 95% CI 0.01–0.10); MCA Vmean reactivity was negatively associated with response speed (β = −0.33, 95% CI −0.19 to −0.02) and positively with memory score (β = 0.28, 95% CI 0.01–0.19). MCA PI reactivity was negatively associated with attention performance (β = −0.29, 95% CI −14.9 to −1.0). Path analyses identified significant paths (p < 0.05) between carotid compliance and carotid diameter reactivity to select domains of cognitive function through MCA reactivity.

Conclusions

NVC was associated with cognitive function in young women. Carotid artery function assessed as carotid compliance and carotid reactivity may contribute to optimal NVC in young women through increased blood flow delivery and reduced blood flow pulsatility.
Echocardiographic characteristics of transcatheter closure of patent foramen ovale with mallow biodegradable occluder: A single-center, phase III clinical study
Authors: Song Lin , Shi Peixuan , Zheng Xiaozhou , Hongxin Li , Li Ziang , Lv Meng , Wang Haiyan
Published: August 2022

Background

Transcatheter occlusion of patent foramen ovale (PFO) has become a recognized treatment option for high-risk PFO-related diseases. However, traditional metal occluders have some disadvantages, such as permanent retention in the body, abrasion of tissues, and obstruction of access to the left side of the heart for interventional procedures. With biodegradable occluders that release non-toxic degradation products and are absorbable by the body, the risk of long-term complications could be greatly reduced. The experimental results of using a PFO-degradable occluder in beagle dogs in early stages, independently developed by Shanghai Mallow Medical Instrument Co., Ltd., showed that the occluding umbrella disc network was degraded 6 months after occlusion. The occluder also showed good memory, biocompatibility, and mechanical properties.

Methods

As one of the multi-center research units, this prospective Phase III clinical trial study included 16 patients with PFO-related complications who were treated with a degradable occluder. The follow-up period lasted for 12 months to analyze the echocardiographic characteristics and procedural feasibility.

Results

The immediate success rate of the procedure was 100% with no serious complications. Postoperative color Doppler transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) at 12 months showed that one patient with atrial septal aneurysm (ASA) had a residual shunt at the edge of the occluder, and contrast transcranial Doppler (cTCD) showed that all patients were grade I or 0 right-to-left shunts (RLS), indicating that the occlusion success rate was 100%. The occluder gradually degraded after the procedure, particularly when the umbrella disc structure became vague, and the size of the occluder decreased significantly 6 months after occlusion.

Conclusions

PFO closure with a Mallow degradable occluder has a high plugging success rate, is safe and effective, and has no serious complications. However, for PFO closure with special anatomical features, further research with a larger sample size is required. TTE can dynamically, conveniently, and accurately observe the entire degradation process of the occluder.

Clinical Trial Registration

ChiCTR1900024036.
Endothelial NCK2 promotes atherosclerosis progression in male but not female Nck1-null atheroprone mice
Authors: Bywaters Briana C. , Pedraza Gladys , Trache Andreea , Rivera Gonzalo M.
Published: August 2022

A better understanding of endothelial dysfunction holds promise for more effective interventions for atherosclerosis prevention and treatment. Endothelial signaling by the non-catalytic region of the tyrosine kinase (NCK) family of adaptors, consisting of NCK1 and NCK2, has been implicated in cardiovascular development and postnatal angiogenesis but its role in vascular disease remains incompletely understood. Here, we report stage- and sex-dependent effects of endothelial NCK2 signaling on arterial wall inflammation and atherosclerosis development. Male and female Nck1-null atheroprone mice enabling inducible, endothelial-specific Nck2 inactivation were fed a high fat diet (HFD) for 8 or 16 weeks to model atherosclerosis initiation and progression, respectively. Analysis of aorta preparations en face during disease progression, but not initiation, showed a significant reduction in plaque burden in males, but not females, lacking endothelial NCK2 relative to controls. Markers of vascular inflammation were reduced by endothelial NCK2 deficiency in both males and females during atherosclerosis progression but not initiation. At advanced stages of disease, plaque size and severity of atherosclerotic lesions were reduced by abrogation of endothelial NCK2 signaling only in males. Collectively, our results demonstrate stage- and sex-dependent modulation of atherosclerosis development by endothelial NCK2 signaling.
Using human induced pluripotent stem cell-derived cardiomyocytes to understand the mechanisms driving cardiomyocyte maturation
Authors: Hamledari Homa , Asghari Parisa , Jayousi Farah , Aguirre Alejandro , Maaref Yasaman , Barszczewski Tiffany , Ser Terri , Moore Edwin , Wasserman Wyeth , Klein Geltink Ramon , Teves Sheila , Tibbits Glen F.
Published: August 2022

Cardiovascular diseases are the leading cause of mortality and reduced quality of life globally. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide a personalized platform to study inherited heart diseases, drug-induced cardiac toxicity, and cardiac regenerative therapy. However, the immaturity of CMs obtained by current strategies is a major hurdle in utilizing hiPSC-CMs at their fullest potential. Here, the major findings and limitations of current maturation methodologies to enhance the utility of hiPSC-CMs in the battle against a major source of morbidity and mortality are reviewed. The most recent knowledge of the potential signaling pathways involved in the transition of fetal to adult CMs are assimilated. In particular, we take a deeper look on role of nutrient sensing signaling pathways and the potential role of cap-independent translation mediated by the modulation of mTOR pathway in the regulation of cardiac gap junctions and other yet to be identified aspects of CM maturation. Moreover, a relatively unexplored perspective on how our knowledge on the effects of preterm birth on cardiovascular development can be actually utilized to enhance the current understanding of CM maturation is examined. Furthermore, the interaction between the evolving neonatal human heart and brown adipose tissue as the major source of neonatal thermogenesis and its endocrine function on CM development is another discussed topic which is worthy of future investigation. Finally, the current knowledge regarding transcriptional mediators of CM maturation is still limited. The recent studies have produced the groundwork to better understand CM maturation in terms of providing some of the key factors involved in maturation and development of metrics for assessment of maturation which proves essential for future studies on in vitro PSC-CMs maturation.
Influence of radiation diurnal variation on the rapid intensification process of super Typhoon Rammasun (1409) in the South China Sea
Authors: Zhang Xinghai , Wei Na , Wang Qian
Published: August 2022

In this study, a sensitivity experiment based on a numerical model is conducted to study the influence of the diurnal variation of radiation on the rapid intensification process of Super Typhoon Rammasun (1409) in the South China Sea. The result shows that changing the radiation process can change the onset time of the rapid intensification process of the typhoon and its maximum intensity. Vertical wind shear is a key factor in the TC rapid intensification influenced by diurnal radiation cycle, and the diurnal variation of radiation process causes obvious diurnal variation in vertical wind shear by changing the thermal difference between sea and land. The oscillation of vertical wind shear promotes the diurnal variation of the typhoon rainband, with an opposite variation trend in the control and sensitivity experiments, affecting the local convective available potential energy and inward transport of entropy and thus influencing the onset time of deep convective in the typhoon inner core region. By changing the establishment of the typhoon warm core (especially the upper-level warm core), deep convections finally affect the rapid intensification of the typhoon.
Optical Character Recognition of Power Equipment Nameplate for Energy Systems Based on Recurrent Neural Network
Authors: Zhang Xun , Bai Wanrong , Cui Haoyang
Published: August 2022

To address the problems of poor accuracy and response time of optical character recognition of power equipment nameplates for energy systems, which are ascribed to exposure to natural light and rainy weather, this paper proposes an optical character recognition algorithm for nameplates of power equipment that integrates recurrent neural network theory and algorithms with complex environments. The collected image power equipment nameplates are preprocessed via graying and binarization in order to enhance the contrast among features of the power equipment nameplates and thus reduce the difficulty of positioning. This innovation facilitates the application of image recognition processing algorithms in power equipment nameplate positioning, character segmentation, and character recognition operations. Following segmentation of the power equipment nameplate and normalization thereof, the characters obtained are unified according to size, and then used as the input of the recurrent neural network (RNN); meanwhile, corresponding Chinese characters, numbers and alphabetic characters are used as the output. The text data recognition system model is realized via the trained RNN network, and is verified by inputting a large dataset into training. Compared with existing text data recognition systems, the algorithm proposed in this paper achieves a Chinese character recognition accuracy of 99.90%, an alphabetic and numeric character recognition accuracy of 99.30%, and a single image recognition speed of 2.15 ms.
Continuous assessment of the adaptability between river network connectivity and water security in a typical highly urbanized area in eastern China
Authors: Gu Yicheng , Wang Siru , Hu Qingfang , Sun Jinhua , Cai Mei , Lu Zhihua , Gao Mingyuan
Published: August 2022

Urbanization has reduced river network connectivity, posing a great threat to water security. However, the mechanism through which changes in river network connectivity impact water security remains uncertain. River network connectivity and water security have been separately and thoroughly assessed by several researchers; however, few studies conducted a coupled assessment of these two aspects together, which may shed light on this mechanism. Based on assessment indicators developed in previous studies and key influence factors identified in the study area, this study proposed a comprehensive evaluation method to continually evaluate the adaptability between river network connectivity and water security in the Wuchengxiyu region, a highly urbanized area in Eastern China. The continuous evaluation was conducted for the period 2010–2019 based on the coupling coordination degree calculation formula. The results show that from 2010 to 2015, the coupling coordination degree between river network connectivity and water security followed a downward trend, due to the uncoordinated development between water systems and urbanization. After 2015, an increasing trend was observed with the implementation of environmental policies. In the past decade, the water surface rate and the coverage rate of suitable flow velocity decreased from 4.59% to 4.28% and from 54.1% to 30.9%, respectively, which may have negative effects on water quality and limit the improvement of regional flood control capacity. Moreover, the evaluation results also prove that policies such as the Ecological River–Lake Construction and the River Chief System have contributed to improve the quality of the water environment and regional flood control. The proposed assessment framework can be used as a guidance to evaluate the relationship between water network connectivity and water security; moreover, it provides new ideas for water network system protection and water quality maintenance in similar highly urbanized areas.
Amorphous silica amendment to improve sandy soils’ hydraulic properties for sustained plant root access under drying conditions
Authors: Zarebanadkouki Mohsen , Hosseini Bahareh , Gerke Horst H. , Schaller Jörg
Published: August 2022

Climate scenarios predict more frequent and longer drought periods, potentially threatening agricultural yield. The water holding capacity of soils is crucial in controlling drought stress intensity for plants. Recently, amorphous silica was suggested to increase soil water holding capacity and availability. The objective of this study was to explore the potential impact of Si application to soils on the retention and flow of water in soils and their consequence on plant access to water under soil drying conditions. Two sandy soils were mixed with varying contents (0, 1 and 5% g/g) of some selected ASi amendments. The soil water retention and soil hydraulic conductivity were determined using evaporation measurement device implemented in a commercial device called HYPROP. For both soils, an application of ASi at rates of 1 or 5% increased the water holding capacity and soils treated with ASi maintained a higher hydraulic conductivity under soil drying conditions than the control soil. Simulation demonstrated that soils treated with ASi could longer sustain the transpirational demand of plants during a soil drying cycle. These first results confirm expected positive crop-growth effect of silica amendments on hydraulic properties of coarse-textured soils mainly by longer keeping up capillary flow during water extraction by plant roots.
Environmental and ecotoxicological effects of drugs used for the treatment of COVID 19
Authors: Efrain Merma Chacca Donal , Maldonado Ingrid , Vilca Franz Zirena
Published: August 2022

Consumption of different pharmaceuticals has increased since the COVID-19 pandemic. Some health institutions worldwide approved the use of drugs such as ivermectin, hydroxychloroquine, azithromycin, dexamethasone, favipiravir, remdesivir, lopinavir-ritonavir, chloroquine, dexamethasone for the treatment of the virus. Once consumed by humans, these compounds are released in urine and faeces, ending up in wastewater and conducted to treatment plants or directly discharged without prior treatment into surface water and soil, with minimum values recorded between 7 ng/L and < 0.08 μg/L for azithromycin and ivermectin respectively, as well as dexamethasone with 0.73 ng/L in surface water and an average of 50–60 ng/L for favipiravir. Their presence has numerous toxicological effects on aquatic and terrestrial species, influencing population decline and altering the growth of organisms. However, the environmental consequences of pharmaceuticals in the environment are poorly known, especially for antivirals studied in this article. This work aims to analyze the presence, treatment and ecotoxicity of drugs used in the pandemic COVID 19, mainly focusing on aquatic and terrestrial ecosystems since that is where they arrive through wastewater. Ecotoxicological effects on flora, fauna and humans are also analyzed. Once there, they persist in the environment causing severe ecological damage, developmental and growth disorders in animals and plants and, in many cases, even the death of species.
Species richness and turnover patterns for tropical and temperate plants on the elevation gradient of the eastern Himalayan Mountains
Authors: Thorne James H. , Choe Hyeyeong , Dorji Lobzang , Yangden Kezang , Wangdi Dorji , Phuntsho Younten , Beardsley Karen
Published: August 2022

Understanding species’ elevational distributions in mountain ecosystems is needed under climate change, but remote biodiverse mountain areas may be poorly documented. National Forest Inventories (NFIs) offer a potential source of data. We used NFI records from Bhutan to ask three questions about elevational richness patterns of Himalayan woody plant species. First, does the mean elevation for all species differ from those species whose entire elevational distribution is recorded in the survey? Second, how does the elevation of maximum richness differ when combining species originating from temperate and tropical regions vs. analyzing them separately? And third, do the highest species turnover rates adjoin elevation zones of maximum species richness? We used 32,198 species records from 1685 forest plots along a 7570 m gradient to map species elevation ranges. Species whose entire range was documented were those whose lowest records are located above 400 m, while bare rock defined all species’ upper limits. We calculated species richness and turnover using 400 m elevation bands. Of 569 species, 79% of temperate and 61% of tropical species’ elevation ranges were fully sampled within the NFI data. Mean elevation of tree and shrub species differed significantly for temperate and tropical species. Maximum combined species richness is from 1300 to 1700 m (277 species), differing significantly from maximum tropical (900–1300 m, 169) and temperate species richness (2500–2900 m, 92). Temperate tree turnover rate was highest in the bands adjoining its maximum species richness (2500–2900 m). But turnover for tropical trees was highest several bands above their maximum species richness, where turnover and decrease in richness interact. Shrub species turnover patterns are similar, but rates were generally higher than for trees. Bhutan’s NFI records show that woody plant species are arrayed on the Himalaya in part according to floristic origins, and that combining temperate- and tropical-originating floras for gradient-based studies such as species richness and turnover obscures actual elevational patterns. In addition, species whose ranges extend below the Himalayan elevation gradient should be accounted for in future studies that correlate climate and environment factors with elevational species richness patterns.
FN1 overexpression is correlated with unfavorable prognosis and immune infiltrates in breast cancer
Authors: Zhang Xiu-Xia , Luo Jun-Hua , Wu Li-Qiang
Published: August 2022

Objective: To investigate the correlation of fibronectin 1 (FN1) expression with prognosis and tumor-infiltrating immune cells in breast cancer (BRCA).

Methods: FN1 mRNA and protein expressions were analyzed through Tumor Immune Estimation Resource (TIMER), Gene Set Cancer Analysis (GSCA), Human Protein Atlas (HPA) databases, and immunohistochemical analysis. The clinicopathological characteristics and genetic factors affecting the FN1 mRNA expression were assessed by various public databases. Then, we analyzed the prognostic value of FN1 in BRCA by Kaplan-Meier plotter, receiver operating characteristic, and Cox regression analyses. Further, the UCSC Xena database was used to retrieve TCGA-BRCA expression profiles for functional enrichment analysis and immune cell infiltration analysis. The potential drugs for the BRCA patients with high- FN1 expression were identified using the connectivity map analysis.

Results: FN1 was upregulated in BRCA tissues compared with normal tissues. High FN1 mRNA expression was correlated with poor clinical outcomes and had good performance in predicting the survival status of BRCA patients. Further, Cox regression analysis showed that FN1 was an independent prognostic factor for predicting the overall survival of patients with BRCA. Moreover, hypermethylation of FN1 contributed to a better prognosis for BRCA patients. Functional enrichment analyses revealed the ECM-receptor interaction pathway and focal adhesion as the common pathways. Moreover, FN1 showed a significant association with tumor-infiltrating immune cells and immune checkpoint inhibitors. Several drugs such as telmisartan, malotilate, and seocalcitol may have therapeutic effects in BRCA patients with high FN1 expression.

Conclusion: FN1 might serve as a novel prognostic biomarker and a novel therapeutic target for BRCA. Besides, the association of FN1 with immune cells and immune checkpoint inhibitors may provide assistance for BRCA treatment.