bluuebunny/crossref_metadata_2025 huggingface dataset:
Flexible polarimetric probe for 3 × 3 Mueller matrix measurements of biological tissue
Authors: Forward Sarah , Gribble Adam , Alali Sanaz , Lindenmaier Andras A. , Vitkin I. Alex
Published: September 2017

Polarimetry is a noninvasive method that uses polarised light to assess biophysical characteristics of tissues. A series of incident polarisation states illuminates a biological sample, and analysis of sample-altered polarisation states enables polarimetric tissue assessment. The resultant information can, for example, help quantitatively differentiate healthy from pathologic tissue. However, most bio-polarimetric assessments are performed using free-space optics with bulky optical components. Extension to flexible fibre-based systems is clinically desirable, but is challenging due to polarisation-altering properties of optical fibres. Here, we propose a flexible fibre-based polarimetric solution, and describe its design, fabrication, calibration, and initial feasibility demonstration in ex vivo tissue. The design is based on a flexible fibre bundle of six multimode optical fibres, each terminated with a distal polariser that ensures pre-determined output polarisation states. The resultant probe enables linear 3 × 3 Mueller matrix characterization of distal tissue. Potential in vivo Mueller matrix polarimetric tissue examinations in various directly-inaccessible body cavities are envisioned.
Effect of caloric restriction on gut permeability, inflammation markers, and fecal microbiota in obese women
Authors: Ott Beate , Skurk Thomas , Hastreiter Ljiljana , Lagkouvardos Ilias , Fischer Sandra , Büttner Janine , Kellerer Teresa , Clavel Thomas , Rychlik Michael , Haller Dirk , Hauner Hans
Published: September 2017

Recent findings suggest an association between obesity, loss of gut barrier function and changes in microbiota profiles. Our primary objective was to examine the effect of caloric restriction and subsequent weight reduction on gut permeability in obese women. The impact on inflammatory markers and fecal microbiota was also investigated. The 4-week very-low calorie diet (VLCD, 800 kcal/day) induced a mean weight loss of 6.9 ± 1.9 kg accompanied by a reduction in HOMA-IR (Homeostasis model assessment-insulin resistance), fasting plasma glucose and insulin, plasma leptin, and leptin gene expression in subcutaneous adipose tissue. Plasma high-molecular weight adiponectin (HMW adiponectin) was significantly increased after VLCD. Plasma levels of high-sensitivity C-reactive protein (hsCRP) and lipopolysaccharide-binding protein (LBP) were significantly decreased after 28 days of VLCD. Using three different methods, gut paracellular permeability was decreased after VLCD. These changes in clinical parameters were not associated with major consistent changes in dominant bacterial communities in feces. In summary, a 4-week caloric restriction resulted in significant weight loss, improved gut barrier integrity and reduced systemic inflammation in obese women.
The Effect of Item Similarity and Response Competition Manipulations on Collaborative Inhibition in Group Recall
Authors: Zhang Huan , Fu Yao , Zhang Xingli , Shi Jiannong
Published: September 2017

Collaborative inhibition refers to when people working together remember less than their predicted potential. The most common explanation for this effect is the retrieval-disruption hypothesis during collaborative recall. However, several recent studies have obtained conflicting results concerning this hypothesis. In the current study, item similarity was manipulated in Experiment 1 by requiring participants to study overlapping or non-overlapping unrelated wordlists. The unstructured instructions were then manipulated during a turn-taking recall task between conditions. The results showed that collaborative inhibition occurred for both overlapping and non-overlapping conditions. Subsequently, response competition during collaborative recall, in addition to item similarity, was manipulated in Experiment 2, and the results showed that when collaborative group members were instructed to recall in turn and monitor their partner’s recall (the medium- and high-response-competition conditions), collaborative inhibition occurred. However, no such effect was shown when collaborative group members were instructed not to communicate with each other, but to simply recall in turn while in a group (low-response-competition condition). Together, these results suggest that the conflicts between the findings of the aforementioned studies were probably caused by differing instructions, which induced response competition in collaborative settings. Aside from retrieval-disruption, other possible mechanisms underlying collaborative inhibition were also discussed.
Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners
Authors: Sluchanko Nikolai N. , Tugaeva Kristina V. , Greive Sandra J. , Antson Alfred A.
Published: September 2017

In eukaryotes, several “hub” proteins integrate signals from different interacting partners that bind through intrinsically disordered regions. The 14-3-3 protein hub, which plays wide-ranging roles in cellular processes, has been linked to numerous human disorders and is a promising target for therapeutic intervention. Partner proteins usually bind via insertion of a phosphopeptide into an amphipathic groove of 14-3-3. Structural plasticity in the groove generates promiscuity allowing accommodation of hundreds of different partners. So far, accurate structural information has been derived for only a few 14-3-3 complexes with phosphopeptide-containing proteins and a variety of complexes with short synthetic peptides. To further advance structural studies, here we propose a novel approach based on fusing 14-3-3 proteins with the target partner peptide sequences. Such chimeric proteins are easy to design, express, purify and crystallize. Peptide attachment to the C terminus of 14-3-3 via an optimal linker allows its phosphorylation by protein kinase A during bacterial co-expression and subsequent binding at the amphipathic groove. Crystal structures of 14-3-3 chimeras with three different peptides provide detailed structural information on peptide-14-3-3 interactions. This simple but powerful approach, employing chimeric proteins, can reinvigorate studies of 14-3-3/phosphoprotein assemblies, including those with challenging low-affinity partners, and may facilitate the design of novel biosensors.
Robust magnon-photon coupling in a planar-geometry hybrid of inverted split-ring resonator and YIG film
Authors: Bhoi Biswanath , Kim Bosung , Kim Junhoe , Cho Young-Jun , Kim Sang-Koog
Published: September 2017

We experimentally demonstrate strongly enhanced coupling between excited magnons in an Yttrium Iron Garnet (YIG) film and microwave photons in an inverted pattern of split-ring resonator (noted as ISRR). The anti-crossing effects of the ISRR’s photon mode and the YIG’s magnon modes were found from |S21|-versus-frequency measurements for different strengths and directions of externally applied magnetic fields. The spin-number-normalized coupling strength (i.e. single spin-photon coupling) $${g}_{{\rm{eff}}}/2\pi \sqrt{N}$$

g

eff

/
2
π

N

was determined to 0.194 Hz ($${g}_{{\rm{eff}}}/2\pi $$

g

eff

/
2
π
 = 90 MHz) at 3.7 GHz frequency. Furthermore, we found that additional fine features in the anti-crossing region originate from the excitation of different spin-wave modes (such as the magnetostatic surface and the backward-volume magnetostatic spin-waves) rather than the Kittel-type mode. These spin-wave modes, as coupled with the ISRR mode, modify the anti-crossing effect as well as their coupling strength. An equivalent circuit model very accurately reproduced the observed anti-crossing effect and its coupling strength variation with the magnetic field direction in the planar-geometry ISRR/YIG hybrid system. This work paves the way for the design of new types of high-gain magnon-photon coupling systems in planar geometry.
A resource of large-scale molecular markers for monitoring Agropyron cristatum chromatin introgression in wheat background based on transcriptome sequences
Authors: Zhang Jinpeng , Liu Weihua , Lu Yuqing , Liu Qunxing , Yang Xinming , Li Xiuquan , Li Lihui
Published: September 2017

Agropyron cristatum is a wild grass of the tribe Triticeae and serves as a gene donor for wheat improvement. However, very few markers can be used to monitor A. cristatum chromatin introgressions in wheat. Here, we reported a resource of large-scale molecular markers for tracking alien introgressions in wheat based on transcriptome sequences. By aligning A. cristatum unigenes with the Chinese Spring reference genome sequences, we designed 9602 A. cristatum expressed sequence tag-sequence-tagged site (EST-STS) markers for PCR amplification and experimental screening. As a result, 6063 polymorphic EST-STS markers were specific for the A. cristatum P genome in the single-receipt wheat background. A total of 4956 randomly selected polymorphic EST-STS markers were further tested in eight wheat variety backgrounds, and 3070 markers displaying stable and polymorphic amplification were validated. These markers covered more than 98% of the A. cristatum genome, and the marker distribution density was approximately 1.28 cM. An application case of all EST-STS markers was validated on the A. cristatum 6 P chromosome. These markers were successfully applied in the tracking of alien A. cristatum chromatin. Altogether, this study provided a universal method of large-scale molecular marker development to monitor wild relative chromatin in wheat.
Ex vivo treatment of patient biopsies as a novel method to assess colorectal tumour response to the MEK1/2 inhibitor, Selumetinib
Authors: Novo Sonia M. , Wedge Stephen R. , Stark Lesley A.
Published: September 2017

Although an array of new therapeutics has emerged for the treatment of colorectal cancer, their use is significantly impacted by variability in patient response. Better pre-clinical models could substantially improve efficacy as it may allow stratification of patients into the correct treatment regime. Here we explore acute,ex vivotreatment of fresh, surgically resected human colorectal tumour biopsies as a novel pre-clinical model for identifying patient response to specific therapeutics. The MEK1/2 inhibitor, Selumetinib (AZD6244, ARRY-142886) was used as a tool compound. Firstly, we established an acute treatment protocol and demonstrated this protocol could differentiate phenotypic and pharmacodynamic responses to Selumetinib (0–3uM). We then used the protocol to evaluate Selumetinib response in tumours from 23 colon cancer patients. These studies revealed that the agent inhibited pERK1/2 phosphorylation in all tumours, caused a significant decrease in proliferation in 5/23 (22%) tumours, and thatKRAS/BRAFmutant tumours were particularly sensitive to the anti-proliferative effects of the agent. These data are consistent with data from clinical trials of Selumetinib, suggesting that acute treatment of small tumour biopsies is worthy of further exploration as a pre-clinical model to evaluate colorectal cancer response to novel therapies.
Amplitude of travelling front as inferred from 14C predicts levels of genetic admixture among European early farmers
Authors: Silva Fabio , Vander Linden Marc
Published: September 2017

Large radiocarbon datasets have been analysed statistically to identify, on the one hand, the dynamics and tempo of dispersal processes and, on the other, demographic change. This is particularly true for the spread of farming practices in Neolithic Europe. Here we combine the two approaches and apply them to a new, extensive dataset of 14,535 radiocarbon dates for the Mesolithic and Neolithic periods across the Near East and Europe. The results indicate three distinct demographic regimes: one observed in or around the centre of farming innovation and involving a boost in carrying capacity; a second appearing in regions where Mesolithic populations were well established; and a third corresponding to large-scale migrations into previously essentially unoccupied territories, where the travelling front is readily identified. This spatio-temporal patterning linking demographic change with dispersal dynamics, as displayed in the amplitude of the travelling front, correlates and predicts levels of genetic admixture among European early farmers.
Ultrasensitive Nano-rt-iPCR for Determination of Polybrominated Diphenyl Ethers in Natural Samples
Authors: Zhang Xiaohan , Ping Xianyin , Zhuang Huisheng
Published: September 2017

Extensive polybrominated diphenyl ethers (PBDEs) use has resulted in its increasingly widespread presence in the environment. PBDEs release from existing products can still persist and accumulate in the environment as well as in human and wildlife magnifying through the food web. Due to its ultra-trace amount in the environment, a novel ultrasensitive nano-rt-iPCR assay has been developed to determine polybrominated diphenyl ethers in natural samples. Numerous amino-DNA and polyclonal antibody (anti-PBDE) were immobilized onto the single-walled carbon nanotubes (SWCNTs) to form antibody-SWCNTs-DNA signal amplifier used in the proposed immunoassay system. Compared with rt-iPCR, this nano-rt-iPCR assay had a higher ratio of signal DNA, which meant higher signal measured and lower detection limit. This proposed nano-rt-iPCR assay was used to determine PBDEs in water samples ranging from 0.5 pg/L to 0.5ng/L; giving the LOD 1 pg/L. To the best of our knowledge, this nano-rt-iPCR is the most sensitive method for PBDEs detection. Because of that, this method needs no pre-concentration or extractions, using sample sizes as low as 10 µL. In general, this nano-rt-iPCR method will be a useful and potential way for batch detection of ultra-trace PBDEs in the aquatic environment.
Abnormal arterial-venous fusions and fate specification in mouse embryos lacking blood flow
Authors: Hwa Jennifer J. , Beckouche Nathan , Huang Lawrence , Kram Yoseph , Lindskog Henrik , Wang Rong A.
Published: September 2017

The functions of blood flow in the morphogenesis of mammalian arteries and veins are not well understood. We examined the development of the dorsal aorta (DA) and the cardinal vein (CV) in Ncx1−/− mutants, which lack blood flow due to a deficiency in a sodium calcium ion exchanger expressed specifically in the heart. The mutant DA and CV were abnormally connected. The endothelium of the Ncx1−/− mutant DA lacked normal expression of the arterial markers ephrin-B2 and Connexin-40. Notch1 activation, known to promote arterial specification, was decreased in mutant DA endothelial cells (ECs), which ectopically expressed the venous marker Coup-TFII. These findings suggest that flow has essential functions in the DA by promoting arterial and suppressing venous marker expression. In contrast, flow plays a lesser role in the CV, because expression of arterial-venous markers in CV ECs was not as dramatically affected in Ncx1−/− mutants. We propose a molecular mechanism by which blood flow mediates DA and CV morphogenesis, by regulating arterial-venous specification of DA ECs to ensure proper separation of the developing DA and CV.
Association between plasma gamma-glutamyltransferase fractions and metabolic syndrome among hypertensive patients
Authors: Franzini Maria , Scataglini Ilenia , Ricchiuti Angelo , Fierabracci Vanna , Paolicchi Aldo , Pompella Alfonso , Dell’Omo Giulia , Pedrinelli Roberto , Corti Alessandro
Published: September 2017

Among the risk factors associated to metabolic syndrome (MetS), hypertension shows the highest prevalence in Italy. We investigated the relationship between the newly identified serum γ-glutamyltransferase (GGT) fractions, b- s- m- f-GGT, and risk factors associated to MetS in hypertensive patients. A total of ninety-five consecutive hypertensive patients were enrolled. GGT fractions were analysed by gel-filtration chromatography, and hepatic steatosis was evaluated by ultrasound. MetS was diagnosed in 36% of patients. Considering the whole group, b- and f-GGT showed the highest positive correlation with BMI, glucose, triglycerides and insulin, and the highest negative correlation with HDL cholesterol. While both serum triglycerides and insulin were independently associated with b-GGT levels, only triglycerides were independently associated with f-GGT. The values of b-GGT activity increased with steatosis grade (g0 = 1.19; g2 = 3.29; ratio g2/g0 = 2.75, p < 0.0001 linear trend). Patients with MetS showed higher levels of b-GGT, m-GGT and f-GGT [median (25th–75th) U/L: 3.19 (1.50–6.59); 0.55 (0.26–0.81); 10.3 (9.1–13.6); respectively] as compared to subjects presenting with one or two MetS criteria [1.75 (0.95–2.85), p < 0.001; 0.33 (0.19–0.60), p < 0.05; 8.8 (7.0–10.6), p < 0.001]. Our data point to a potential role for b- and f-GGT fractions in identifying MetS patients among hypertensive subjects, thus providing a minimally invasive blood-based tool for MetS diagnosis.
Exercise training enhances in vivo clearance of endotoxin and attenuates inflammatory responses by potentiating Kupffer cell phagocytosis
Authors: Komine Shoichi , Akiyama Kentaro , Warabi Eiji , Oh Sechang , Kuga Keisuke , Ishige Kazunori , Togashi Shinji , Yanagawa Toru , Shoda Junichi
Published: September 2017

The failure of Kupffer cells (KCs) to remove endotoxin is an important factor in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). In this study, the effects of exercise training on KC function were studied in terms ofin vivoendotoxin clearance and inflammatory responses. Mice were allocated into rest and exercise groups. KC bead phagocytic capacity and plasma steroid hormone levels were determined following exercise training. Endotoxin and inflammatory cytokine levels in plasma were determined over time following endotoxin injection. KC bead phagocytic capacity was potentiated and clearance of exogenously-injected endotoxin was increased in the exercise group. Inflammatory cytokine (TNF-α and IL-6) levels were lower in the exercise group. We found that only DHEA was increased in the plasma of the exercise group. In anin vitroexperiment, the addition of DHEA to RAW264.7 cells increased bead phagocytic capacity and attenuated endotoxin-induced inflammatory responses. These results suggest that exercise training modulatesin vivoendotoxin clearance and inflammatory responses in association with increased DHEA production. These exercise-induced changes in KC capacity may contribute to a slowing of disease progression in NAFLD patients.
Evaluation of circulating levels of CCN2/connective tissue growth factor in patients with ST-elevation myocardial infarction
Authors: Ritschel Vibeke , Shetelig Christian , Seljeflot Ingebjørg , Limalanathan Shanmuganathan , Hoffmann Pavel , Halvorsen Sigrun , Arnesen Harald , Eritsland Jan , Andersen Geir Øystein
Published: September 2017

CCN2/Connective tissue growth factor seems to be involved in development of cardiac hypertrophy and fibrosis, but a possible cardioprotective role in left ventricular (LV) remodelling following myocardial infarction has also been suggested. The main objectives of the study were therefore to investigate whether circulating CCN2 levels were associated with infarct size, LV function, adverse remodelling or clinical outcome in two cohorts of patients with ST-elevation myocardial infarction (STEMI). CCN2 was measured in 988 patients 18 hours after PCI and clinical events were recorded after 55 months in the BAMI cohort. In the POSTEMI trial, serial measurements of CCN2 were performed in 258 STEMI patients during index hospitalisation and cardiac magnetic resonance imaging was performed in the acute phase and after 4 months. Clinical events were also recorded. There were no significant associations between levels of CCN2 and infarct size, LV ejection fraction, changes in LV end-diastolic or end-systolic volume, myocardial salvage or microvascular obstruction. There were no significant associations between CCN2 levels and clinical events including mortality, in either of the study cohorts. In conclusion, circulating levels of CCN2 measured in the acute phase of STEMI were not associated with final infarct size, left ventricular function or new clinical events.
Correction: Corrigendum: High-throughput screening of metal-porphyrin-like graphenes for selective capture of carbon dioxide
Authors: Bae Hyeonhu , Park Minwoo , Jang Byungryul , Kang Yura , Park Jinwoo , Lee Hosik , Chung Haegeun , Chung ChiHye , Hong Suklyun , Kwon Yongkyung , Yakobson Boris I. , Lee Hoonkyung
Published: September 2017

Scientific Reports 6: Article number: 21788; published online: 23 February 2016; updated: 13 September 2017. This Article contains an error in Table 1, where ‘B i (eV/K)’ should read ‘B i (meV/K)’.
Bioactivity of Ionic Liquids
Authors: Ferraz Ricardo , Teixeira Cátia , Gomes Paula , Prudêncio Cristina
Published: September 2017

Ionic liquids are well-known for their remarkable physical and chemical properties, which triggered their use as green-solvents and materials with unique and tuneable characteristics. This tuneability frequently relies on just selecting suitable ions for a specific need rather than on complex covalent modifications, making ionic liquids attractive for diverse research areas, from materials science to electrochemistry and from catalysis to medicinal chemistry. Still, although ionic liquids currently enjoy a plethora of applications in various domains, their use in the life sciences has been less explored. Therefore, the present work is focused on some biological activities that have been reported for ionic liquids.
Vibrational spectroscopy and imaging: applications for tissue engineering
Authors: Querido William , Falcon Jessica M. , Kandel Shital , Pleshko Nancy
Published: September 2017

We review applications of vibrational spectroscopy for tissue engineering applications.
Designed synthesis of SnO2–C hollow microspheres as an anode material for lithium-ion batteries
Authors: Hu Lin-Lin , Yang Li-Ping , Zhang Dong , Tao Xian-Sen , Zeng Chen , Cao An-Min , Wan Li-Jun
Published: September 2017

We report a simple and facile synthetic protocol to prepare an SnO2–C hollow composite, which shows improved battery performance when used as an anode material in lithium ion batteries.
Crystallization and growth morphology of barium titanate and fresnoite from a glass with the composition 20.1Na2O·23.1BaO·23TiO2·9.8B2O3·21SiO2·3Al2O3
Authors: Harizanova Ruzha , Wisniewski Wolfgang , Avdeev Georgi , Rüssel Christian
Published: September 2017

SEM-micrograph of a cut plane through a blackberry BaTiO3 growth structure tilted at 70° and the respective EBSD-patterns.
Exploring coherent electron excitation and migration dynamics by electron diffraction with ultrashort X-ray pulses
Authors: Yuan Kai-Jun , Bandrauk André D.
Published: September 2017

Exploring ultrafast charge migration is of great importance in biological and chemical reactions.
PEG coated vesicles from mixtures of Pluronic P123 and l-α-phosphatidylcholine: structure, rheology and curcumin encapsulation
Authors: Dutta Bijaideep , Barick K. C. , Verma Gunjan , Aswal V. K. , Freilich Inbar , Danino Dganit , Singh B. G. , Priyadarsini K. I. , Hassan P. A.
Published: September 2017

PEGylated vesicles from co-assembly of block copolymers and lipids for drug encapsulation.
Synthesis, structure and properties of bimetallic sodium rare-earth (RE) borohydrides, NaRE(BH4)4, RE = Ce, Pr, Er or Gd
Authors: Payandeh GharibDoust SeyedHosein , Ravnsbæk Dorthe B. , Černý Radovan , Jensen Torben R.
Published: September 2017

Formation, stability and properties of new metal borohydrides within RE(BH4)3–NaBH4, RE = Ce, Pr, Er or Gd is investigated.
Tunable hysteresis effect for perovskite solar cells
Authors: Rong Yaoguang , Hu Yue , Ravishankar Sandheep , Liu Huawei , Hou Xiaomeng , Sheng Yusong , Mei Anyi , Wang Qifei , Li Daiyu , Xu Mi , Bisquert Juan , Han Hongwei
Published: September 2017

The tunable hysteresis effect of perovskite solar cells clarifies the importance of the c-TiO2/perovskite interface, and provides significant insights towards the understanding of this rapidly developing photovoltaic technology.
Piceatannol inhibits the IL-1β-induced inflammatory response in human osteoarthritic chondrocytes and ameliorates osteoarthritis in mice by activating Nrf2
Authors: Tang Qian , Feng Zhenhua , Tong Minji , Xu Jianxiang , Zheng Gang , Shen Liyan , Shang Ping , Zhang Yu , Liu Haixiao
Published: September 2017

Potential molecular mechanism involved in piceatannol treatment in osteoarthritis.
Microfluidic production of nanoscale perfluorocarbon droplets as liquid contrast agents for ultrasound imaging
Authors: Xu Xiaonan , Song Ruyuan , He Minghao , Peng Chuan , Yu Miao , Hou Youmin , Qiu Huihe , Zou Ruhai , Yao Shuhuai
Published: September 2017

Monodisperse liquid perfluorocarbon nanodroplets are produced in a stable tip-streaming microfluidic flow, and show excellent contrast enhancement for ultrasound imaging.
Metabolomics reveal mitochondrial and fatty acid metabolism disorders that contribute to the development of DKD in T2DM patients
Authors: Li Ling , Wang Chengshi , Yang Hongliu , Liu Shuyun , Lu Yanrong , Fu Ping , Liu Jingping
Published: September 2017

Diabetic kidney disease (DKD) is the leading cause of ESRD; however, early intervention can greatly prevent the progression of DKD; thus, sensitive biomarkers for DKD are still required.
TEM nano-Moiré evaluation for an invisible lattice structure near the grain interface
Authors: Zhang Hongye , Wen Huihui , Liu Zhanwei , Zhang Qi , Xie Huimin
Published: September 2017

An inverse TEM nano-Moiré method has been proposed, for the first time, to reconstruct an invisible lattice structure near the grain interface.
Carrier scattering in quasi-free standing graphene on hexagonal boron nitride
Authors: Kim Sun Jun , Park Byeongho , Noh Seung Hyo , Yoon Hyong Seo , Oh Juyeong , Yoo SangHyuk , Kang Keonwook , Han Byungchan , Jun Seong Chan
Published: September 2017

Graphene on h-BN showed nonlinear characteristic considerably in radio frequency signal transmission under low temperature.
Biobased, self-healable, high strength rubber with tunicate cellulose nanocrystals
Authors: Cao Liming , Yuan Daosheng , Xu Chuanhui , Chen Yukun
Published: September 2017

Cellulose nanocrystals represent a promising and environmentally friendly reinforcing nanofiller for polymers, especially for rubbers and elastomers.
A simple way to achieve bioinspired hybrid wettability surface with micro/nanopatterns for efficient fog collection
Authors: Yin Kai , Du Haifeng , Dong Xinran , Wang Cong , Duan Ji-An , He Jun
Published: September 2017

We present a simple, low-cost method to prepare a hybrid superhydrophobic–hydrophilic surface for efficient fog collection.
Correction: A study of pH-dependence of shrink and stretch of tetrahedral DNA nanostructures
Authors: Wang Ping , Xia Zhiwei , Yan Juan , Liu Xunwei , Yao Guangbao , Pei Hao , Zuo Xiaolei , Sun Gang , He Dannong
Published: September 2017

Correction for ‘A study of pH-dependence of shrink and stretch of tetrahedral DNA nanostructures’ by Ping Wang et al., Nanoscale, 2015, 7, 6467–6470.
Correction: Stereodivergent synthesis of right- and left-handed iminoxylitol heterodimers and monomers. Study of their impact on β-glucocerebrosidase activity
Authors: Stauffert Fabien , Serra-Vinardell Jenny , Gómez-Grau Marta , Michelakakis Helen , Mavridou Irene , Grinberg Daniel , Vilageliu Lluïsa , Casas Josefina , Bodlenner Anne , Delgado Antonio , Compain Philippe
Published: September 2017

Correction for ‘Stereodivergent synthesis of right- and left-handed iminoxylitol heterodimers and monomers. Study of their impact on β-glucocerebrosidase activity’ by Fabien Stauffert et al., Org. Biomol. Chem., 2017, 15, 3681–3705.
Variation of carbon coatings on the electrochemical performance of LiFePO4 cathodes for lithium ionic batteries
Authors: Jiang Weiwei , Wu Mengqiang , Liu Fei , Yang Jian , Feng Tingting
Published: September 2017

Asphalt-derived and glucose-derived carbon proved to be soft carbon-coating (SCC) and hard carbon-coating (HCC), and it was found that LFP/SCC showed a superior performance in capacity and rate capability than that of LFP/HCC.
Development and application of immobilized surfactant in mass spectrometry-based proteomics
Authors: Wu Qiong , Jiao Fenglong , Gao Fangyuan , Xia Chaoshuang , Lv Yayao , Yu Qian , Zhang Yangjun , Qian Xiaohong
Published: September 2017

The synthesis process of Fe3O4@TMOS, a surfactant for the pretreatment of complex biological samples.
Highly stretchable hydrogels from complex coacervation of natural polyelectrolytes
Authors: Lalevée Gautier , David Laurent , Montembault Alexandra , Blanchard Kevin , Meadows John , Malaise Sébastien , Crépet Agnès , Grillo Isabelle , Morfin Isabelle , Delair Thierry , Sudre Guillaume
Published: September 2017

Polyelectrolyte complexation between chitosan and hyaluronic acid at pH between 2 and 3 leads to highly stretchable hydrogels.
High gain observer design for fractional‐order non‐linear systems with delayed measurements: application to synchronisation of fractional‐order chaotic systems
Authors: Bettayeb Maamar , Al‐Saggaf Ubaid M. , Djennoune Said
Published: September 2017

In this study, a high gain observer with delayed driving control signal is designed for synchronisation of fractional‐order chaotic systems. The method consists in using two cascade high gain observers in order to compensate for the delay transmission signal from the transmitter to the receiver. For large delay, a fractional‐order chain observer composed by high gain cascade delayed observers is proposed. The last observer of this chain estimates the state at the current time while previous observers estimate delayed states. Convergence of the proposed observer is proven. Application to the synchronisation of fractional‐order chaotic systems is given. Computer simulations show the effectiveness of the proposed approach.
Detailed long‐term hydro‐thermal scheduling for expansion planning in the Nordic power system
Authors: Helseth Arild , Mo Birger , Lote Henden Arild , Warland Geir
Published: September 2017

The authors describe a method for long‐term hydro‐thermal scheduling allowing treatment of detailed large‐scale hydro systems. Decisions for each week are determined by solving a two‐stage stochastic linear programming problem considering uncertainty in weather and exogenous market prices. The overall scheduling problem is solved by embedding such two‐stage problems in a rolling horizon simulator. The method is verified on data for the Nordic power system, studying the incremental changes in expected socio‐economic surplus for expansions in both the transmission and generation systems. Comparisons are made with a widely used existing long‐term hydro‐thermal scheduling model. The results indicate that the model is well suited to valuate the flexibility of hydropower in systems with a high share of intermittent renewable generation.
Fault tolerance performance of dual‐inverter‐based six‐phase drive system under single‐, two‐, and three‐phase open‐circuit fault operation
Authors: Melo Victor Felipe Moura Bezerra , Jacobina Cursino Brandão , Rocha Nady
Published: September 2017

Considering that so far all studies regarding multiphase drives fault tolerance performance have been carried out making use of conventional two‐level inverters, this study discusses the fault tolerance performance of a six‐phase drive system based on a dual inverter under single‐, two‐, or three‐phase open‐circuit fault. Aiming applications where simplicity and low computation efforts are required and fast dynamic response is not imperative, an open‐loop volts/hertz (V/f) compensation strategy is discussed in order to keep the rated operation even after the occurrence of the fault, assuring the maintenance of sinusoidal flux. The six‐phase machine mathematical model after the fault is detailed and utilised to elaborate the compensation strategy. Simulation and experimental results show the validity of the discussed solution and its feasibility.
Quadratic boost derived hybrid multi‐output converter
Authors: Ahmad Anish , Bussa Vinod Kumar , Singh Rajeev Kumar , Mahanty Ranjit
Published: September 2017

In this study, two quadratic boost derived hybrid multi‐output converter topologies are proposed. The proposed converters are capable of giving n‐number of simultaneous ac and one dc outputs. The proposed converters are developed from a single switch quadratic boost converter by replacing its main switch by either n‐number of series connected H‐bridge or n‐number of parallel connected H‐bridge inverter topologies. The converter developed from n‐series connected H‐bridge inverters give series mode of the proposed converter and is capable of giving n‐number of ac outputs with variable voltages and same currents (to all the ac loads) along with one dc output. Further, the converter developed from n‐parallel connected H‐bridge inverters give parallel mode of the proposed converter and can give n‐number of ac outputs with same voltages (to all the ac loads) and variable currents along with one dc output. Due to the quadratic behaviour of the proposed hybrid multi‐output converters, high voltage gain can be achieved from small shoot‐through duty cycle. The proposed converter topologies can be applied for simultaneous dc/ac and dc/dc power conversion in a hybrid microgrid. Steady state and dynamic modelling have been carried out for analysing the steady state and transient behaviour of the proposed hybrid converters for two ac and one dc outputs. Simulation and experimental results are presented and efficiency analysis is carried out to validate the performance of the proposed converter topologies for two ac and one dc outputs.
Turn‐off analysis of FS‐IGBTs based on a simplified analytical model
Authors: Ding Shun , Xing Yan , Wu Hongfei , Hu Haibing , Wang Jun
Published: September 2017

Normally for IGBTs five stages can be identified during Turn‐Off transient, among which stage 3 and 4 are most complicated and time consuming in calculation, due to its intrinsically complicated physics process. In this paper, through extensive experiments, we found an interesting phenomenon that in stage 3 the slope of the driving gate voltage is linearly related to the FS‐IGBT voltage and current, which greatly simplifies modeling and calculation. In stage 4, we further simplify the model by assuming (i) no interactive effects between the redistribution current and combination current; (ii) the base excess carrier density at depletion boundary far less than that at FSL boundary; (iii) The total charge in the base only relating to carrier life time. With these simplifications, equivalent circuit for each stage with less calculation efforts is developed, and the running time of the simulation under Matlab is less than one second. A double‐pulse testing platform was built. The experimental results for both test beds with single IGBT and two IGBTs in series connection match the proposed model developed in Matlab pretty well, under quite different operating conditions, with the maximum error on both IL–Eoff and VDC–Eoff<17%.
Synthesis of Internal Alkynes through an Effective Tandem ­Elimination–Hydrodebromination–Cross-Coupling of gem-­Dibromoalkenes with Halobenzenes
Authors: Ji Yuan , Zhong Ning , Kang Zinan , Yan Guobing , Zhao Ming
Published: September 2017

Carbon–carbon couplings are among the most important strategies for constructing functional molecules in organic synthetic chemistry, and cheap, diverse, and readily available coupling partners are crucial to these diverse reactions. In this contribution, we report the first palladium-catalyzed C–C cross-coupling reaction of two kinds of organic halide, a gem-dibromoalkene and a halobenzene, as the starting materials. Terminal alkynes were generated in situ through a tandem elimination–hydrodebromination process, and the internal alkyne final products were synthesized in one pot. The reaction proceeded under simple, facile, and classic copper-free Sonogashira coupling reaction conditions in good to excellent yields.
The Tissue Factor Pathway and Wound Healing
Authors: Hoffman Maureane
Published: September 2017

The role of tissue factor (TF) as the major initiator of hemostatic blood coagulation is well recognized. The ability to form an adequate hemostatic clot is essential to the normal healing of an injury by staunching bleeding, stabilizing the injured tissue, and serving as a scaffold for repair processes. Also, some molecules produced during hemostasis, particularly thrombin, have cytokine and growth factor-like activities that contribute to inflammation and repair. However, TF itself has activities as a regulator of cellular processes via direct signaling, as well as by facilitating activation of proteolytically activated receptors by activated factors VII and X. The importance of hemostasis in the host response to injury makes it very difficult to separate the hemostatic from nonhemostatic effects of TF on wound healing. The literature in this area remains sparse but suggests that TF influences the course and tempo of healing by cell signaling events that impact inflammation, epithelialization, and angiogenesis.
Platelet RNA in Cancer Diagnostics
Authors: Tjon-Kon-Fat Lee-Ann , Sol Nik , Wurdinger Thomas , Nilsson R.
Published: September 2017

Platelets are involved in several steps of cancer metastasis. During this process, platelets are exposed to the tumor and its environment, thereby exchanging biomolecules with the tumor cells and resulting in tumor-mediated “education” of the platelets and a change in their RNA profile. Analysis of platelet RNA profiles or direct measurement of tumor-derived biomarkers within platelets can provide information on ongoing cancer-related processes in the individual (e.g., whether the patient has cancer, the tumor type, and possibly identify oncogenic alterations driving the disease for treatment selection). The close interaction with the disease process and the ability to respond to systemic alterations make platelets an interesting biosource for implementation in precision medicine.
Use of a Powered Stapling System for Minimally Invasive Lung Volume Reduction Surgery: Results of a Prospective Double-Blind Single-Center Randomized Trial
Authors: Akil Ali , Semik Michael , Freermann Stefan , Reichelt Jan , Redwan Bassam , Görlich Dennis , Fischer Stefan
Published: September 2017

Background Video-assisted thoracoscopic surgery (VATS)-lung volume reduction surgery (LVRS) represents an important treatment option for patients with advanced lung emphysema. For VATS lung resection, endoscopic staplers are routinely used. Recently, a new generation of electronically powered stapling systems was developed. In this study, the iDrive powered stapling system (Covidien, Germany) was first tested during VATS-LVRS and compared with a non-electronic conventional device.

Methods Forty patients with advanced emphysema were enrolled in a prospective randomized trial. All patients underwent bilateral VATS-LVRS. Patients were randomized for iDrive use on the right lung (n = 20) or left lung resection (n = 20). A conventional endoscopic stapler (EndoGIA, Covidien) was used for contralateral resection in same patients. Therefore, 40 resections were performed with the iDrive and 40 with the EndoGIA. The duration of surgery, air leakage after extubation, and on postoperative day 1 (POD1), as well as length of chest tube therapy, were documented.

Results The application of the new system was uneventful. Mean duration of surgery was 52 ± 2.5 minute in the iDrive group compared with 54 ± 3.8 minute in the EndoGIA-group (p = 0.5). After extubation, the mean air leakage in the iDrive-group did not differ significantly from that in the EndoGIA-group (p = 0.6). This was also observed on POD1 (p = 0.7). Moreover, length of drainage therapy also did not show significant differences between both groups (p = 0.6).

Conclusion The iDrive powered stapling system offers one-handed, push-button operation, which eliminates the manual firing force and possibly enables more precise resection. In the current study, the novel system led to comparable results with the conventional mechanical stapler without any disadvantages in patients undergoing bilateral VATS-LVRS.
Postoperative Computed Tomography Evaluation of Posterior Tibial Plateau Fractures: Mean 7-Year Clinical Follow-Up
Authors: Li Dongzhe , Liang Yu , Ma Kunlong , Zou Chang , Fang Yue
Published: September 2017

The aim is to assess the association between computed tomography (CT) findings and clinical outcomes in posterior tibial plateau fractures (TPF). This is a retrospective analysis of the records of 23 patients with posterior TPF treated at our institution between 2004 and 2011. Two indices of residual articular displacement of posterior TPF (gap and step-off) were measured from CT images, and clinical outcomes were assessed using the Short Musculoskeletal Function Assessment (SMFA) questionnaire. Spearman's rank correlation coefficient analysis was used to evaluate the correlations between the postoperative posterior TPF radiological findings and the clinical outcomes. Both the intraobserver and the interobserver correlation coefficients were high (0.90 and 0.92, respectively), indicating excellent agreement between the reviewers for the assessment of residual displacement via CT scans. Additionally, residual articular step displacement showed a strongly negative correlation with clinical outcomes (R = 0.700, p = 0.036), whereas the residual gap displacement did not (R = 0.400, p = 0.505). More importantly, the medial posterior step displacement was significantly correlated with the clinical outcomes (p = 0.040), whereas the lateral posterior step displacement was not (p = 0.618). Based on the data of this study, the higher the step-off deformity of the medial posterior tibial plateau, the worse the SMFA. More attention should be paid to this factor when treating medial posterior TPF.
Comparative Analysis between Cone and Sleeve in Managing Severe Bone Defect during Revision Total Knee Arthroplasty: A Systematic Review and Meta-Analysis
Authors: Kim Hyun Jung , Lee O-Sung , Lee Seung Hoon , Lee Yong Seuk
Published: September 2017

This review aims to compare the outcomes of revision total knee arthroplasty (TKA) performed using a tantalum cone and a titanium sleeve. A rigorous and systematic search was performed. Each of the selected studies was evaluated for methodological quality. Data were extracted according to the following: study design, level of evidence, cases enrolled, age, sex ratio, follow-up, involved part, bone defect, degree of constraint, augments (cone and/or sleeve), pre-clinical score, post-clinical score, radiological results, major complications, and endpoint analysis. Nineteen articles were included in the final analysis. The knee scores of the cone and sleeve groups were increased in all studies with or without statistical significance. For the radiological outcome, radiolucent line was seen in six cases in the cone group and in 15 cases in the sleeve group. Only a few specific augment-related complications were noted. Our results support the use of the newly devised augments in bone defect during revision TKA in terms of clinical and radiological outcome.
German Heart Surgery Report 2016: The Annual Updated Registry of the German Society for Thoracic and Cardiovascular Surgery
Authors: Funkat Anne-Katrin , Lewandowski Jana , Frie Michael , Ernst Markus , Hekmat Khosro , Schiller Wolfgang , Gummert Jan , Harringer Wolfgang , Beckmann Andreas
Published: September 2017

Based on a long-standing voluntary registry founded by the German Society for Thoracic and Cardiovascular Surgery (GSTCVS), well-defined data of all cardiac, thoracic, and vascular surgery procedures performed in 78 German heart surgery departments during the year 2016 are analyzed. In 2016, a total of 103,128 heart surgery procedures (implantable defibrillator, pacemaker, and extracardiac procedures excluded) were submitted to the registry. Approximately 15.7% of the patients were at least 80 years of age, resulting in an increase of 0.9% compared with the data of 2015. For 37,614 isolated coronary artery bypass grafting procedures (relationship on-/off-pump 4.4:1), an unadjusted in-hospital mortality of 2.9% was observed. Concerning the 33,451 isolated heart valve procedures (including 11,701 catheter-based procedures), the unadjusted in-hospital mortality was 4.3%.

This annual updated registry of the GSTCVS represents voluntary public reporting by accumulating actual information for nearly all heart surgical procedures in Germany, describes advancements in heart medicine, and is a basis for internal and external quality assurances for all participants. In addition, the registry demonstrates that the provision of cardiac surgery in Germany is appropriate and patients are treated nationwide at all times.
Misoprostol in Addition to a Double-Balloon Catheter for Induction: A Double-Blind Randomized Controlled Trial
Authors: Gonzalez Maritza , Lo-Ciganic Wei-Hsuan , Reed Kathryn , Hill Meghan
Published: September 2017

Objective This article aims to evaluate whether the use of a double-balloon catheter with oral misoprostol results in a lower rate of cesarean and shorter times to delivery than the use of the double-balloon catheter with oral placebo.

Study Design In a double-blind randomized controlled trial, a double-balloon catheter was used for induction of labor with two doses of either 50 µg of misoprostol or placebo. Outcomes included cesarean rate, time to vaginal delivery, change in Bishop's score, and oxytocin usage.

Results A total of 343 women were screened and 199 randomized: 99 to the misoprostol arm and 100 to the placebo arm. Cesarean delivery rate was not different between the groups (misoprostol: 13.1% vs. placebo: 17.0%, p = 0.45). Time to vaginal delivery was significantly shorter (mean: 14.6 ± 6.9 vs. 20.8 ± 13.8 hours, p < 0.0001), change in Bishop's score was significantly greater (median: 5 vs. 4 points, p = 0.005), and use of oxytocin was significantly less frequent (86.9 vs. 98.0% patients, p = 0.01) in the misoprostol group.

Conclusion The use of a double-balloon catheter with oral misoprostol for induction did not reduce the cesarean delivery rate, but did result in shorter labors, a greater increase in Bishop's score, and a lower need for oxytocin use.
Mayor incidencia de quistes sinoviales en muñecas hiperlaxas
Authors: Mirchandani A. S. , Balan S. A. , García-Elías M.
Published: September 2017

El grado de laxitud articular de la mano de 34 pacientes intervenidos de un quiste sinovial de muñeca fue medido y comparado con el de un grupo control compuesto por personas de la misma edad y sexo. Todas las mediciones realizadas demostraron una mayor movilidad articular en el grupo de pacientes que en el grupo control. El test de Lichtman, que investiga la laxitud mediocarpiana, fue positivo en una mayor proporción de pacientes con gangliones que en el grupo control. Estos hallazgos sugieren la posibilidad de que la laxitud articular pueda ser un factor predisponerte en la patogénesis de los quistes sinoviales.
Aspectos técnicos de la fijación percutánea de las fracturas de escafoides
Authors: Palou C.
Published: September 2017

La fijación percutánea de fracturas del escafoides se ha establecido como una opción quirúrgica en los últimos años. Esta es una técnica fiable y efectiva, pero con poco margen de error. Se describen los aspectos técnicos para hacer este procedimiento más fácil y evitar complicaciones.