bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of climate change on cerebrospinal meningitis morbidities and mortalities: A longitudinal and community-based study in Ghana
Authors: Akanwake John Baptise , Atinga Roger Ayimbillah , Boafo Yaw Agyeman
Published: August 2022

Cerebrospinal Meningitis (CSM) is one of the climate-sensitive diseases affected by global climate change. Its causal agent, Neisseria meningitidis bacterial, thrives well in warm environments. CSM epidemics are likely to be exacerbated by the warming globe emanating from climate change. Yet studies have rarely examined the association between climat’e change and CSM. Moreover, studies drawing on quantitative and qualitative data to understand the pathways of climate change domains and CSM relationships as well as community perspectives of CSM are rare. This study deployed mixed-method research to analyse community perceptions of and the relationship between climate change and CSM. We collected 96 months of data on changes in metrological weather parameters (temperatures, sunshine, relative and absolute humidity, and rainfall) and CSM cases and mortalities recorded between 2012 and 2019. Community-level data were elicited using a semi-structured questionnaire. The results showed a statistically significant relationship between climate variables and CSM. High temperatures and sunshine, low rainfall, low relative and absolute humidity were significantly associated with CSM outbreaks. Community participants demonstrated fair knowledge about CSM and attributed its outbreak to climate change. The respondents asserted that the symptoms of CSM, such as severe headache, high fever, stiff neck and waist pains, among others, are often prevalent in their communities when there is high temperature, low relative and absolute humidity, excessive sunshine and dusty winds (harmattan winds). They also revealed that poor environmental sanitation, poor room ventilation, overcrowding in a room, and social integration such as festivals, markets, and religious activities, among others, can exacerbate the outbreak of CSM. We recommend awareness campaign in the communities on the need to ensure proper ventilation in their homes and workplaces, keep their surroundings clean and preserve the econ-system to reduce high temperatures.
DrNote: An open medical annotation service
Authors: Frei Johann , Soto-Rey Iñaki , Kramer Frank
Published: August 2022

In the context of clinical trials and medical research medical text mining can provide broader insights for various research scenarios by tapping additional text data sources and extracting relevant information that is often exclusively present in unstructured fashion. Although various works for data like electronic health reports are available for English texts, only limited work on tools for non-English text resources has been published that offers immediate practicality in terms of flexibility and initial setup. We introduce DrNote, an open source text annotation service for medical text processing. Our work provides an entire annotation pipeline with its focus on a fast yet effective and easy to use software implementation. Further, the software allows its users to define a custom annotation scope by filtering only for relevant entities that should be included in its knowledge base. The approach is based on OpenTapioca and combines the publicly available datasets from WikiData and Wikipedia, and thus, performs entity linking tasks. In contrast to other related work our service can easily be built upon any language-specific Wikipedia dataset in order to be trained on a specific target language. We provide a public demo instance of our DrNote annotation service athttps://drnote.misit-augsburg.de/.
Effectiveness of targeted antenatal family planning information provision on early postpartum family planning uptake in Kisumu County: Protocol for a simple randomized control trial (I DECIDE Study)
Authors: Shisanya Morris Senghor , Ouma Collins , Kipmerewo Mary
Published: August 2022

Overlooking the contraceptive needs of postpartum women constitutes missed opportunities in health system. Inter-birth interval of at least three years can prevent poor maternal, perinatal and neonatal outcomes and afford women socio-economic benefits of family planning (FP). The unmet need for FP in the postpartum period remains unacceptably high and far exceeds the FP unmet need of other women. The Kenya Demographic and Health Survey (KDHS) estimate the unmet need for postpartum FP to be 74%. Maternal and Child Health (MCH) continuum provides a great opportunity for postpartum FP (PPFP) interventions integration especially antenatal targeted FP information giving and gauging of fertility intentions. However, there is no protocol for structured, targeted antenatal FP information giving and behavioural contracting to influence postpartum fertility intentions of mothers before delivery. Knowledge gap regarding fertility intentions and best antenatal strategies for postpartum FP still exists. The available evidence differs across settings and demography. Equally, there has been inadequate exploration of operationally-feasible ways to integrate FP counselling into existing ANC services with limited number of methodologically rigorous trials. The current protocol will therefore examine the effectiveness of targeted antenatal family planning information provision on early postpartum FP uptake using a randomized control trial in Kisumu County, Kenya. The protocol will assess socio-cultural beliefs towards PPFP and perceived individual control of PPFP choice, analyze knowledge and intention for PPFP, and finally compare and examine the determinants of PPFP uptake between study groups. Through simple sampling, a group of 246 antenatal mothers will be randomly assigned to control, community and facility intervention groups as per eligibility criteria in the study facilities. After at least 3 months of intervention and postpartum follow-up, clinical superiority will be used to gauge which intervention was effective and the model superiority. Questionnaire and Case Report Forms will be the main source of data. The participant will form the unit of analysis which will be by intention to treat. Bivariate analysis will be applied as the selection criteria for inclusion of predictors of intention and uptake in the final logistic regression model. Odds Ratios and 95% confidence interval (CI) will be used to demonstrate significance and the strength of association between selected variables. Dissemination will be through conference presentations and peer reviewed journals. The trial has been registered with the Pan African Clinical Trials Registry PACTR202109586388973 on the 28th September 2021.
A novel speech emotion recognition method based on feature construction and ensemble learning
Authors: Guo Yi , Xiong Xuejun , Liu Yangcheng , Xu Liang , Li Qiong
Published: August 2022

In the field of Human-Computer Interaction (HCI), speech emotion recognition technology plays an important role. Facing a small number of speech emotion data, a novel speech emotion recognition method based on feature construction and ensemble learning is proposed in this paper. Firstly, the acoustic features are extracted from the speech signal and combined to form different original feature sets. Secondly, based on Light Gradient Boosting Machine (LightGBM) and Sequential Forward Selection (SFS) method, a novel feature selection method named L-SFS is proposed. And then, the softmax regression model is used to learn automatically the weights of the four single weak learners including Support Vector Machine (SVM), K-Nearest Neighbor (KNN), Extreme Gradient Boosting (XGBoost) and LightGBM. Lastly, based on the learned automatically weights and the weighted average probability voting strategy, an ensemble classification model named Sklex is constructed, which integrates the above four single weak learners. In conclusion, the method reflects the effectiveness of feature construction and the superiority and stability of ensemble learning, and gets good speech emotion recognition accuracy.
Contamination of sea urchin Mesocentrotus nudus by radiocesium released during the Fukushima Daiichi Nuclear Power Plant accident
Authors: Rithu Mst. Nazira Akhter , Matsumoto Akira , Hirakawa Naoto , Ito Yukari , Arakawa Hisayuki
Published: August 2022

Countless marine organisms were polluted with radioactive materials that were dispersed when the Fukushima Daiichi Nuclear Power Plant (FDNPP) was damaged in 2011 by the Great East Japan Earthquake. The aim of this study was to determine the degree to which marine herbivorous sea urchins,Mesocentrotus nudus, were contaminated with radiocesium because of the accident. We collected samples of sea urchins from four locations in Fukushima prefecture (at the coast and offshore from the Yotsukura and Ena stations) and investigated how the137Cs activity concentrations changed. The biological half-life (Tbio) of137Cs in the individual sea urchins was between 121 and 157 days. The ecological half-life (Teco) of137Cs was 181–423 days and was high in places close to the FDNPP. TheTecovalues in the sea urchins were longer than previously reported. The results infer that the food sources of the sea urchins around the Fukushima coast strongly influenced their uptake of137Cs.
Validity and reliability of the Baecke questionnaire against accelerometer-measured physical activity in community dwelling adults according to educational level
Authors: Tebar William R. , Ritti-Dias Raphael M. , Fernandes Rômulo A. , Damato Tatiana M. M. , Barros Mauro V. G. de , Mota Jorge , Andersen Lars Bo , Christofaro Diego G. D.
Published: August 2022

Baecke questionnaire have been widely used to assess physical activity. However, the role of educational level on validity and reliability of Baecke questionnaire is still not stablished, being a factor that can potentially influence the accuracy of self-reported measures. The present study aimed to verify the validity and reliability of Baecke questionnaire for the measurement of physical activity in community dwelling adults according to education level. The sample included 251 adults (42.4±17.0 years, 55% of women). Physical activity was self-reported by Baecke questionnaire and objectively measured by accelerometer. The education level (EL) was classified by years of study into low (<8 years), medium (8–11 years) and high (>11 years). A 7-day test-retest reliability was analyzed by intraclass correlation coefficient. The relationship, agreement and validity of the Baecke questionnaire against accelerometry were analyzed by Spearman’s correlation, Kappa index, and ROC curve, respectively. The reliability of Baecke questionnaire were r = 0.97 (high EL), r = 0.78 (medium EL), and r = 0.68 (low EL). Sensitivity and specificity were 77% and 71% in high EL, 54% and 80% in medium EL and 33% and 89% in the low EL. Baecke questionnaire proved to be reliable and a valid measurement of habitual physical activity in adults with medium and high EL.
Integrated 3d flow-based multi-atlas brain structure segmentation
Authors: Li Yeshu , Qiu Ziming , Fan Xingyu , Liu Xianglong , Chang Eric I-Chao , Xu Yan
Published: August 2022

MRI brain structure segmentation plays an important role in neuroimaging studies. Existing methods either spend much CPU time, require considerable annotated data, or fail in segmenting volumes with large deformation. In this paper, we develop a novel multi-atlas-based algorithm for 3D MRI brain structure segmentation. It consists of three modules: registration, atlas selection and label fusion. Both registration and label fusion leverage an integrated flow based on grayscale and SIFT features. We introduce an effective and efficient strategy for atlas selection by employing the accompanying energy generated in the registration step. A 3D sequential belief propagation method and a 3D coarse-to-fine flow matching approach are developed in both registration and label fusion modules. The proposed method is evaluated on five public datasets. The results show that it has the best performance in almost all the settings compared to competitive methods such as ANTs, Elastix, Learning to Rank and Joint Label Fusion. Moreover, our registration method is more than 7 times as efficient as that of ANTs SyN, while our label transfer method is 18 times faster than Joint Label Fusion in CPU time. The results on the ADNI dataset demonstrate that our method is applicable to image pairs that require a significant transformation in registration. The performance on a composite dataset suggests that our method succeeds in a cross-modality manner. The results of this study show that the integrated 3D flow-based method is effective and efficient for brain structure segmentation. It also demonstrates the power of SIFT features, multi-atlas segmentation and classical machine learning algorithms for a medical image analysis task. The experimental results on public datasets show the proposed method’s potential for general applicability in various brain structures and settings.
Association of body composition in early pregnancy with gestational diabetes mellitus: A meta-analysis
Authors: Rahnemaei Fatemeh Alsadat , Abdi Fatemeh , Pakzad Reza , Sharami Seyedeh Hajar , Mokhtari Fatemeh , Kazemian Elham
Published: August 2022

Introduction

Body composition as dynamic indices constantly changes in pregnancy. The use of body composition indices in the early stages of pregnancy has recently been considered. Therefore, the current meta-analysis study was conducted to investigate the relationship between body composition in the early stages of pregnancy and gestational diabetes.

Method

Valid databases searched for papers published from 2010 to December 2021 were based on PRISMA guideline. Newcastle Ottawa was used to assess the quality of the studies. For all analyses, STATA 14.0 was used. Mean difference (MD) of anthropometric indices was calculated between the GDM and Non-GDM groups. Pooled MD was estimated by “Metan” command, and heterogeneity was defined using Cochran’sQtest of heterogeneity, andI2index was used to quantify heterogeneity.

Results

Finally, 29 studies with a sample size of 56438 met the criteria for entering the meta-analysis. Pooled MD of neck circumference, hip circumference, waist hip ratio, and visceral adipose tissue depth were, respectively, 1.00 cm (95% CI: 0.79 to 1.20) [N = 5; I^2: 0%; p: 0.709], 7.79 cm (95% CI: 2.27 to 13.31) [N = 5; I2: 84.3%; P<0.001], 0.03 (95% CI: 0.02 to 0.04) [N = 9; I2: 89.2%; P<0.001], and 7.74 cm (95% CI: 0.11 to 1.36) [N = 4; I^2: 95.8%; P<0.001].

Conclusion

Increased neck circumference, waist circumference, hip circumference, arm circumference, waist to hip ratio, visceral fat depth, subcutaneous fat depth, and short stature increased the possibility of developing gestational diabetes. These indices can accurately, cost-effectively, and affordably assess the occurrence of gestational diabetes, thus preventing many consequences with early detection of gestational diabetes.
Population dynamics of Phaius flavus in southeast China: Reproductive strategies and plants conservation
Authors: Li Jun , Zhu Ya-ting , Chen Lun-yan , Lu Ai-xian , Ji Hong-yu , Liu Hai-ping , Li Ze-xin , Lin Zuo-dong , Wu Sha-sha , Zhai Jun-wen
Published: August 2022

Because of species diversity and troubling conservation status in the wild, Orchidaceae has been one of the taxa with most concern in population ecological research for a long time. Although Orchidaceae is a group with high adaptability, they have become endangered for complex and various reasons such as the germination? difficulty and habitat loss, which makes it difficult to develop an accurate protection strategy. Phaius flavus is a terrestrial orchid which used to be widely distributed in central and southern Asia; however, large populations are difficult to find in the wild. Thus, the aim of this study was to provide a new perspective for conserving endangered P. flavus by investigating the mechanisms of its population decline; we established time-specific life and fertility tables, age pyramids, survival curves, and mortality curves for this plant and then conducted Leslie matrix model. We found that both of the populations from Wuhu Mount (WM) and Luohan Mount (LM) showed declining trends and exhibited pot-shaped age pyramids, low net reproductive rates, and negative intrinsic growth rates. The population from the Beikengding Mount (BM) showed a stable status with a bell-shaped age pyramid. However, it has a significant risk of decline because of the low net reproductive rate and intrinsic growth rate. This study use time-specific life and fertility tables, age pyramids, survival curves, and mortality curves, showed that the population decline of P. flavus could be attributed to 1) the shortage of seedlings caused by the low germination rate in the wild and 2) the loss of adult individuals caused by anthropogenic disturbances. To protect this species from extinction in these areas, we suggest that human activities in these habitats should be strictly forbidden and ex situ conservation of this plant in botanical gardens is also necessary.
Assessment of hypertension and other factors associated with the severity of disease in COVID-19 pneumonia, Addis Ababa, Ethiopia: A case-control study
Authors: Ashamo Andargew Yohannes , Bekele Abebaw , Petrose Adane , Gebreyes Tsegaye , Etissa Eyob Kebede , Bekele Amsalu , Haisch Deborah , Schluger Neil W. , Yusuf Hanan , Haile Tewodros , Deyessa Negussie , Kebede Dawit
Published: August 2022

Background

Various reports suggested that pre-existing medical illnesses, including hypertension and other demographic, clinical, and laboratory factors, could pose an increased risk of disease severity and mortality among COVID-19 patients. This study aimed to assess the relation of hypertension and other factors to the severity of COVID-19 pneumonia in patients discharged from Eka Kotebe Hospital in June-September, 2020.

Methods

This is a single-center case-control study of 265 adult patients discharged alive or dead, 75 with a course of severe COVID-19 for the cases arm and 190 with the non-severe disease for the control arm. Three age and sex-matched controls were selected randomly for each patient on the case arm. Chi-square, multivariable binary logistic regression, and odds ratio (OR) with a 95% confidence interval was used to assess the association between the various factors and the severity of the disease. A p-value of <0.05 is considered statistically significant.

Results

Of the 265 study participants, 80% were male. The median age was 43 IQR(36–60) years. Both arms had similar demographic characteristics. Hypertension was strongly associated with the severity of COVID-19 pneumonia based on effect outcome adjustment (AOR = 2.93, 95% CI 1.489, 5.783, p-value = 0.002), similarly, having diabetes mellitus (AOR = 3.17, 95% CI 1.374, 7.313, p-value<0.007), chronic cardiac disease (AOR = 4.803, 95% CI 1.238–18.636, p<0.023), and an increase in a pulse rate (AOR = 1.041, 95% CI 1.017, 1.066, p-value = 0.001) were found to have a significant association with the severity of COVID-19 pneumonia.

Conclusions

Hypertension was associated with the severity of COVID-19 pneumonia, and so were diabetes mellitus, chronic cardiac disease, and an increase in pulse rate.
Rehabilitation interventions for persons with hip fracture and cognitive impairment: A scoping review
Authors: Cadel Lauren , Kuluski Kerry , Wodchis Walter P. , Thavorn Kednapa , Guilcher Sara J. T.
Published: August 2022

Background

Hip fractures are common fall-related injuries, with rehabilitation and recovery often complicated by cognitive impairment. Understanding what interventions exist, and in what settings, for people with hip fracture and co-occurring cognitive impairment is important in order to provide more evidence on rehabilitation and related outcomes for this population.

Objective

To examine the extent, nature, and range of literature on rehabilitation interventions for adults with hip fracture and cognitive impairment.

Methods

Articles were required to: include an adult population with hip fracture and cognitive impairment, include a rehabilitation intervention, and be published between January 1, 2000 and November 19, 2021. Articles were excluded if they were opinion pieces, study protocols, conference abstracts, or if they did not describe the rehabilitation intervention. Relevant articles were searched on the following electronic databases: MEDLINE, EMBASE, CINAHL Plus, APA PsycINFO, Cochrane Library, Web of Science, and the Physiotherapy Evidence Database. All articles were double-screened by two reviewers and disagreements were resolved through consensus. Data were extracted and synthesized using descriptive approaches.

Results

Seventeen articles were included in this scoping review. We identified a variety of interventions targeting this population; about half were specific to physical rehabilitation, with the other half incorporating components that addressed multiple aspects of the care journey. Interventions had varying outcomes and no studies qualitatively explored patient or family experiences. All intervations were initiated in hospital, with less than half including cross-sectoral components. About half of the articles described modifying or tailoring the intervention to the participants’ needs, but there was limited information on how to adapt rehabilitation interventions for individuals with cognitive impairment.

Conclusions

More work is need to better understand patient, family, and provider experiences with rehabilitation interventions, how to tailor interventions for those with cognitive impairment, and how to successfully implement sustainable interventions across sectors.
An in vitro method for inducing titan cells reveals novel features of yeast-to-titan switching in the human fungal pathogen Cryptococcus gattii
Authors: Saidykhan Lamin , Correia Joao , Romanyuk Andrey , Peacock Anna F. A. , Desanti Guillaume E. , Taylor-Smith Leanne , Makarova Maria , Ballou Elizabeth R. , May Robin C.
Published: August 2022

Cryptococcosis is a potentially lethal fungal infection of humans caused by organisms within the Cryptococcus neoformans/gattii species complex. Whilst C. neoformans is a relatively common pathogen of immunocompromised individuals, C. gattii is capable of acting as a primary pathogen of immunocompetent individuals. Within the host, both species undergo morphogenesis to form titan cells: exceptionally large cells that are critical for disease establishment. To date, the induction, defining attributes, and underlying mechanism of titanisation have been mainly characterized in C. neoformans. Here, we report the serendipitous discovery of a simple and robust protocol for in vitro induction of titan cells in C. gattii. Using this in vitro approach, we reveal a remarkably high capacity for titanisation within C. gattii, especially in strains associated with the Pacific Northwest Outbreak, and characterise strain-specific differences within the clade. In particular, this approach demonstrates for the first time that cell size changes, DNA amplification, and budding are not always synchronous during titanisation. Interestingly, however, exhibition of these cell cycle phenotypes was correlated with genes associated with cell cycle progression including CDC11, CLN1, BUB2, and MCM6. Finally, our findings reveal exogenous p-Aminobenzoic acid to be a key inducer of titanisation in this organism. Consequently, this approach offers significant opportunities for future exploration of the underlying mechanism of titanisation in this genus.
Curating Online Collections: Towards an Authentically Digital, Mediation Protocol for Art Digitizations
Authors: Bertrand Stéphanie
Published: August 2022

Since the mid-1990s, cultural organizations have increasingly digitized their physical collections and made them available online; however, museums are still puzzled over what to do with these growing digital collections. Meanwhile, art institutions’ reluctance to produce virtual exhibitions, linked to a prevailing skeuomorphic paradigm, has left the matter of curating art digitizations unresolved. While museum computing scholarship has aptly identified the problematic absence of authentically digital curatorial processes, it has largely overlooked the fact that online collections and in-gallery group shows similarly condition artistic reception owing to a shared database logic, subjecting both to a mediation paradox in contemporary culture. This article examines the effects of this shared logic on public engagement, along with recent digital curatorial strategies that have emerged in response around notions of the digital aura and networked objects. The article concludes by proposing three conditions for an alternative curatorial process capable of adequately mediating art digitizations online without sacrificing aesthetic experience to the limited affordances of screen-based information and communications technologies.
Scorpion Portal Vein Access Utilizing ICE Imaging: A Novel Case of Creating a TIPS Shunt Utilizing a Steerable Needle and US Guided Access System
Authors: Stibbs Peter , Jagannathan Arun
Published: August 2022

Case study describing the novel use of a steerable needle and cannula system under intravascular ultrasound guidence to create a shunt in a hepatic compromised patient with portal hypertension where traditional access attempts via transjugular access have failed. This is the first case described using new needle technology designed for intra parenchymal steering of a portal vein access system within the hepatic anatomy to create a succesful portal to hepatic venous shunt and reduce patient portal hypertension.

Utilizing the Scorpion X™ portal vein access system in conjunction with ICE imaging, successful hepatic to portal access was obtained in less than 5 minutes in a patient where a prior attempt to establish portal to hepatic shunting had failed.
Quality in laboratory medicine and the Journal: walking together
Authors: Plebani Mario
Published: August 2022

Quality in laboratory medicine is defined as “an unfinished journey”, as the more essential the laboratory information provided, the more assured its quality should be. In the past decades, the Journal Clinical Chemistry and Laboratory Medicine has provided a valuable forum for garnering new insights into the analytical and extra-analytical phases of the testing cycle, and for debating crucial aspects of quality in clinical laboratories. The impressive number of papers published in the Journal is testimony to the efforts made by laboratory professionals, national and international scientific societies and federations in the quest to continuously improve upon the pre-, intra- and post-analytical steps of the testing cycle, thus enhancing the quality of laboratory information. The paper appearing in this special issue summarizes the most important and interesting contributions published in the Journal, thus updating our knowledge on quality in laboratory medicine and offering further stimuli to identify the most valuable measures of quality in clinical laboratories.
Towards a Doctrinal Pragmaticism: Charles S. Peirce and the Nature of Doctrine
Authors: Hollingsworth Andrew
Published: August 2022

In this paper, I aim to retrieve insights from the philosophy of the polymath Charles Sanders Peirce, which he referred to as pragmaticism. What Peirce is perhaps best known as is being the father of pragmatism. In order to differentiate his project from other thinkers such as William James and John Dewey, who likewise referred to their projects as pragmatism, he renamed his pragmatism to pragmaticism.Peirce’s pragmaticism has much to offer theologians, especially concerning theological method. I demonstrate this claim by showing the usefulness of three of Peirce’s pragmaticist concepts. The first section of this paper briefly explicates the foundational concepts of pragmaticism, which are the pragmatic(ist) maxim, the semiotic nature of understanding, and fallibilism. The second section of this paper provides a sketch of the benefits these three concepts have for theological method.
A simple, bed-side tool to assess evoked pressure pain intensity
Authors: Hostrup Søren Nicolai Frederiksen , O’Neill Søren Francis Dyhrberg , Larsen Jesper Bie , Arendt-Nielsen Lars , Petersen Kristian Kjær
Published: August 2022

Objectives

Existing equipment for quantitative sensory testing is generally expensive and not easily applicable in a clinical setting thus simple bed-side devices are warranted. Pressure hyperalgesia is a common finding in patients with musculoskeletal pain and an experimental model is delayed-onset muscle soreness (DOMS). DOMS is characterised by muscle hyperalgesia and some studies report facilitation of temporal summation of pain. This study aimed to detect DOMS induced muscle hyperalgesia and temporal summation of pain using a newly developed bed-side quantitative sensory testing device to deliver standardised pressure.

Methods

Twenty-two healthy participants participated in two sessions with the second session approximately 48 h after baseline. Pressure pain intensities were assessed from the gastrocnemius muscle with four probes calibrated to apply 2, 4, 6 and 8 kg, respectively. Temporal summation of pain (10 stimuli delivered at 0.5 Hz using the 6 kg probe) intensities were assessed from the same location. DOMS was evoked in the gastrocnemius muscle by an eccentric exercise. Sleepiness and physical activity were measured with the Epworth Sleepiness Scale and the Global Physical Activity Questionnaire to investigate if they were associated with the quantitative sensory testing measures.

Results

Pressure pain intensity was significantly increased 48 h after induction of DOMS when compared to baseline for all four probes (p<0.05). Temporal summation of pain was not statistically significant affected by DOMS and sleep quality and physical activity did not associate with any of the measures.

Conclusions

This study introduces a simple, bed-side assessment tool for the assessment of pressure pain intensity and hence hyperalgesia and temporal summation of pain.
Dangerous Love: Sex Work, Drug Use, and the Pursuit of Intimacy in Tijuana, Mexico
Authors: Syvertsen Jennifer Leigh
Published: August 2022

The relationships between female sex workers and their noncommercial male partners are often assumed to be coercive and anchored in risk, dismissed as “pimp-prostitute” arrangements by researchers and the general public alike. Yet, these stereotypes unjustly erase the complexity of lives we imagine to be consumed by social suffering. Dangerous Love centers a framework of love to rethink sex workers’ intimate relationships as commitments to collective solidarity and survival in contexts of oppression. Combining epidemiological research and ethnographic fieldwork in Tijuana, Mexico, Jennifer Leigh Syvertsen examines how individuals try to find love and meaning in lives marked by structural violence, social marginalization, drug addiction, and HIV/AIDS. Linking the political economy of inequalities along the border with emotional lived experience, this book explores how intimate relationships become dangerous safe havens that fundamentally shape both partners’ well-being. Through these stories, we are urged to reimagine the socially transformative power of love to carve new pathways to health equity.
Improvement of Accounting Teacher Competencies Through E-Book Creation Training as An Alternative Teaching Material
Authors: Sumaryati Sri , Siswandari Siswandari , Susilaningsih Susilaningsih , Susanti Asri Diah , Ivada Elvia
Published: August 2022

Teacher competence in a learning process is a crucial ingredient that must be continuously improved. Changes in learning implementation strategies during the Covid-19 pandemic provide opportunities and challenges for teachers, especially regarding learning to provide the best service to students. The use of e-books by flipbook applications is considered an alternative to help the learning process. This community service activity aims to improve teacher competence in developing digital media by using flipbook applications as alternative media during online learning. After making an e-book with the flipbook application, it is hoped that the teacher will be more helpful in providing material to students. The activity was carried out through a zoom cloud meeting involving 42 teachers of SMK Negeri 1 Boyolali. The method used in this activity is the importance of managing online learning, training in making e-books using flipbook applications, assisting in making e-books, and evaluating activities. The result of this activity is that teachers can understand digital media's importance and practice making digital media e-books using flipbook applications.
Kompetensi guru dalam sebuah proses pembelajaran menjadi hal pokok yang harus selalu ditingkatkan. Perubahan strategi pelaksanaan pembelajaran pada masa Pandemi Covid-19 memberikan peluang dan sekaligus tantangan bagi guru khususnya terkait dengan pelaksanaan pembelajaran untuk memberikan pelayanan terbaik kepada siswa. Pemanfaatan media digital e-book dengan memanfaatkan aplikasi flipbook dirasakan menjadi sebuah alternatif untuk membantu kelancaran proses pembelajaran. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan kompetensi guru dalam mengembangkan media digital dengan menggunakan aplikasi flipbook sebagai media alternatif selama pembelajaran online. Kegiatan dilaksanakan melalui zoom cloud meeting dengan melibatkan 42 guru SMK Negeri 1 Boyolali. Metode yang digunakan dalam kegiatan ini adalah sosialisasi pentingnya mengelola pembelajaran online, pelatihan pembuatan e-book dengan memanfaatkan aplikasi flipbook, pendampingan pembuatan e-book, dan evaluasi kegiatan. Hasil dari kegiatan ini adalah guru dapat memahami pentingnya media digital dan guru dapat mempraktikkan cara membuat media digital e-book dengan memanfaatkan aplikasi flipbook.
Increasing Food Production with Aquaponic Cultivation System to Support Sustainable Economic Independence During the Covid-19 Pandemic Period, Gunungpati District, Semarang
Authors: Marpaung Grace Natalia , Prajanti Sucihatiningsih Dian Wisika , Nihayah Annis Nurfitriana , Sholeha Atika Estining , Sidik Fajar Rahmat
Published: August 2022

The COVID-19 pandemic occurred when the SARS-CoV2 virus spread throughout the world. It creates a widespread global shock that creates a severe economic slowdown. There has been a slowdown in all sectors of the economy worldwide, and more than a third of the global population has been isolated. It can harm the community and the surrounding environment, especially related to the irregular income many people receive in the village. In overcoming the economic downturn in the community, the service team provided several solutions to help reduce these problems. The solution offered by the service team is Increasing Food Production with Aquaponic Cultivation Systems. The aquaponics cultivation system is easy for rural communities to increase community income and provide benefits to individuals and the surrounding environment. The team chose one village as the place to implement the solution, namely Kalisegoro village. The method used is the active approach, namely the provision of aquaponic cultivation training. The training was carried out using used plastic bottles, tarpaulins, wood, paralon, seeds, water hoses, and planting media.
Pandemi COVID-19 terjadi ketika virus SARS-CoV2 menyebar ke seluruh dunia. Ini menciptakan guncangan global yang meluas yang menciptakan perlambatan ekonomi yang parah. Telah terjadi perlambatan di semua sektor ekonomi di seluruh dunia dan lebih dari sepertiga populasi global telah diisolasi. Hal tersebut dapat memberikan dampak negatif bagi masyarakat dan lingkungan sekitar terutama terkait pendapatan tidak tetap yang diterima oleh banyak masyarakat di desa. Dalam mengatasi penurunan ekonomi masyarakat yang terjadi, tim pengabdian memberikan beberapa solusi untuk membantu mengurangi permasalahan tersebut. Solusi yang ditawarkan tim pengabdian yaitu Peningkatan Produksi Pangan Dengan Sistem Budidaya Aquaponik. Sistem budidaya aquoponik merupakan hal yang mudah bagi masyarakat desa untuk meningkatkan pendapatan masyarakat serta memberikan manfaat bagi individu maupun lingkungan sekitar. Tim memilih satu desa sebagai tempat untuk mengimplementasikan solusi tersebut yaitu desa Kalisegoro. Metode yang digunakan pendekatan aksi yaitu pemberian pelatihan budidaya aquoponik. Pelatihan dilakukan dengan memanfaatkan botol plastik bekas, terpal, kayu, paralon, bibit, selang air dan media tanam.
Endometrial gland-specific progestagen-associated endometrial protein and cilia gene splicing changes in recurrent pregnancy loss
Authors: Pearson-Farr Jennifer E , Wheway Gabrielle , Jongen Maaike S A , Goggin Patricia , Lewis Rohan M , Cheong Ying , Cleal Jane K
Published: August 2022

Endometrial glands are essential for fertility, consisting of ciliated and secretory cells that facilitate a suitable uterine environment for embryo implantation. This study sought to determine whether an endometrial gland-specific transcriptome and splicing profile are altered in women with recurrent pregnancy loss. Our data provide a comprehensive catalogue of cilia and progestagen-associated endometrial protein (PAEP) gene isoforms and relative exon usage in endometrial glands. We report a previously unannotated endometrial gland cilia transcript GALNT11 and its susceptibility to exon skipping. Key endometrial receptivity gene transcripts are also reported to change in endometrial glands of women with recurrent pregnancy loss. The endometrial gland cilia and PAEP targets identified in this study could be used to identify a perturbed endometrium, isolate causes of recurrent pregnancy loss and develop targeted therapies in personalised medicine.

Lay summary

Successful embryo implantation is a trade-off between the lining of the womb which receives an implanting embryo, termed the endometrium, and a good quality embryo. For days 21–24 of the menstrual cycle, the endometrium undergoes changes into a receptive state in which it can receive an implanting embryo. Inappropriate endometrial receptivity is thought to underlie recurrent pregnancy loss. Improving pregnancy success in women with recurrent pregnancy loss requires an increased understanding of the endometrium at the molecular level. Genes contain the instructions for the cell and which genes are turned on or off determine how well it can do its role. We sought to determine a gene expression pattern of human endometrial glands in women with recurrent pregnancy loss (n = 5) vs a control group (n = 5). We identify target genes altered in women with recurrent pregnancy loss. Endometrial gland markers could be used to identify inappropriate endometrial receptivity.
Helmet Use in Preventing Head Injuries in Bicycling, Snow Sports, and Other Recreational Activities and Sports
Authors: Lee Lois K. , Flaherty Michael R. , Blanchard Ashley M. , Agarwal Maneesha ,   THE COUNCIL ON INJURY, VIOLENCE, AND POISON PREVENTION
Published: August 2022

Recreational activities and sports are a common and popular way for youth to enjoy physical activity; however, there are risks related to physical injury. Injuries can potentially result in death and long-term disability, especially from traumatic brain injury. Helmet use can significantly decrease the risk of fatal and nonfatal head injury, including severe traumatic brain injury and facial injuries when participating in recreational sports. The most robust evidence of helmet effectiveness has been demonstrated with bicycling and snow sports (eg, skiing, snowboarding). Despite this evidence, helmets are not worn consistently with all recreational sports. A multipronged approach is necessary to increase helmet use by children and youth participating in recreational sports. This approach includes legislation and enforcement, public educational campaigns, child education programs, and anticipatory guidance from clinicians. This policy statement guides clinicians, public health advocates, and policymakers on best practices for increasing helmet use in recreational sports, including bicycling and snow sports.
The Supervision Over Observance and Enforcement of the Banking Legislation in the Field of Mortgage Lending
Authors:   Volgograd State University, Sandalova Victoria , Azarova Ekaterina ,   Volgograd State University
Published: August 2022

Introduction: the digitalization of information interchange between parties to a civil transaction contributes to the dynamic growth of transactions, including in the banking sector. At the same time, disappointing statistics for the period 2021 – early 2022 indicate a decline in the growth of criminal acts against the individual against the background of a constant increase in malicious acts and offenses in the field of obtaining and issuing borrowings and loans, mortgages with the participation of consumers. Realizing the importance of the human rights activities of the prosecutor’s office in the supervision and control of observance and enforcement of the banking legislation, the leadership of the Prosecutor General’s Office of Russia has designated the sphere of mortgage lending involving citizen participation as the primary area of the prosecutor’s attention. Revealing qualitative indicators in the implementation of supervisory measures by the prosecutor’s office aimed at detecting and suppressing violations of the banking legislation in the field of mortgage lending is the purpose of the scientific study. Methods: the methodological framework for the journalistic research is a set of methods of scientific cognition, among which the main ones are analysis, synthesis, generalization and comparative jurisprudence. Results: the study analyzes the implemented measures within the framework of the prosecutor’s supervision over observance and enforcement of the banking legislation in the field of mortgage lending. A positive trend in the human rights activities of the prosecutor’s office in the direction under study is noted, which has a positive impact, including on judicial practice to protect the rights of borrowers. The opinion is expressed on the need to address organizational issues of interaction of the prosecutor’s office with other agencies with similar powers, and, directly, with credit organizations. Conclusions: the authors are convinced of the importance of the role of the prosecutor’s office in the field under study, which can influence the stability of civil turnover, the formation and implementation of the principles of good faith and freedom of contract. The solution of issues of interdepartmental interaction and problems of information availability of banking information will contribute to strengthening the beneficial effect in the implementation of supervisory measures by the prosecutor’s office aimed at detecting and suppressing violations of the banking legislation in the field of mortgage lending.
The Official Interpretation of Legal Norms as a Tool for Building the Russian Rule of Law
Authors:   Saratov State Law Academy (Balakovo branch), Terekhov Evgeny
Published: August 2022

Introduction: the practical implementation of the idea of the rule of law requires the fullest provision of human and civil rights and freedoms, as well as restrictions on the right of state power. Despite the existence of the necessary legislative framework, contradictions and uncertainties periodically arise in the legal activity regarding the ways of further implementation of the law. The official interpretation of the norms of law helps to cope with this task, which allows for clarity and semantic certainty in the legal regulation processes. Purpose: the demonstration of the use of the official interpretation of legal norms as an independent means of maintaining the efficiency of the rule of law. Methods: the methodological framework for the study is a set of methods of scientific cognition, among which the main ones are systematic, analysis, statistical, historical. Results: the author’s position substantiated in the work is based on the study of the place and practice of using the official interpretation of the legal norms in the construction and maintenance of legal statehood. This is facilitated by the analysis of signs of the rule of law, the normative statistical data, the judicial law enforcement practice, as well as the individual interpretative acts. Conclusions: as a result of the conducted research, it is found that the role of the official interpretation of the legal norms as a tool to promote the efficiency of the rule of law is invaluable and irreplaceable. In fact, the official legal interpretation today is one of the most effective non-alternative means of not only revealing the meaning of laws, but also increasing trust and respect for the law, its knowledge and acceptance as a priority regulator of public relations. The idea of a rule-of-law state will remain an idea, without the use of legal interpretation activities in the legal sphere of society.
Actual Problems of Compensation for Moral Damage Caused to Minors as a Result of Harm to Health
Authors:   Russian State University of Justice (Crimean branch), Ablyatipova Natalia , Volkova Irina ,   Russian State University of Justice (Crimean branch)
Published: August 2022

Introduction: to date, cases of harm to the health of minors are quite common. As a result of the unlawful impact on the health of children, the latter experience physical pain and psychological suffering. To restore violated rights in such cases, the civil legislation provides for the institution of compensation for moral damage, but its imperfections are manifested in the practical implementation of the norms. In this regard, the authors set a goal: to analyze and systematize the positions of civil scientists and the materials of judicial practice to identify the most common problems that arise when considering cases of this category, in particular, when determining the amount of compensation for moral damage. Results: the specifics of the circumstances causing the appeal to the judicial authorities for recovery from the guilty persons who have caused harm to the health of minors, the compensation for moral harm, the lack of the detailed regulation of the mechanism for determining the amount of moral compensation and, as a consequence, the subjective approach of the courts in resolving this issue are studied. Conclusions: based on the analysis of the legislation, the doctrine of civil law, the problems of collecting compensation for moral damage from persons who have committed an infringement on the health of children are formulated. Based on the results of the study, the authors have proposed the recommendations for improving the legislation.