bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of early use of sodium-glucose transport protein 2 inhibitors, glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors on the legacy effect of hyperglycemia
Authors: Deng Siwei , Zhao Houyu , Chai Sanbao , Sun Yexiang , Shen Peng , Lin Hongbo , Zhan Siyan
Published: May 2024

Background

A phenomenon known as legacy effect was observed that poor glycemic control at early stage of patients with newly-diagnosed type 2 diabetes (T2D) increases the risk of subsequent cardiovascular diseases (CVD). Early use of some novel anti-hyperglycemic agents, such as sodium-glucose transport protein 2 inhibitors (SGLT-2i), may attenuate this effect, but the evidence is limited.

Methods

Two retrospective cohorts of newly diagnosed T2D patients from 2010–2023 were assembled using the Yinzhou Regional Health Care Database (YRHCD) with different definitions of the early exposure period - the 1-year exposure cohort and 2-year exposure cohort, which were comprised of subjects who had HbA1c measurement data within 1 year and 2 years after their T2D diagnosis, respectively. Using Cox proportional hazards models, we examined the association between high HbA1c level (HbA1c>7%) during the early exposure period and the risk of subsequent CVD. This analysis was performed in the overall cohort and three subpopulations with different treatments during the early exposure period, including patients initiating SGLT-2i or glucagon-like peptide-1 receptor agonists (GLP-1RA), patients using dipeptidyl peptidase-4 inhibitors (DPP-4i), and patients without using SGLT-2i, GLP-1RA, and DPP-4i. Besides, subgroup analyses were performed by stratifying patients into age <55 and ≥55 years.

Results

A total of 21,477 and 22,493 patients with newly diagnosed T2D were included in the two final cohorts. Compared with patients with mean HbA1c ≤ 7% during the early exposure period, those with HbA1c>7% had higher risks of incident CVD, with a HR of 1.165 (95%CI, 1.056–1.285) and 1.143 (95%CI, 1.044–1.252) in 1-year and 2-year exposure period cohort. Compared to non-users, in patients initiating SGLT-2i/GLP-1RA within 1 or 2 years after T2D diagnosis, higher HbA1c level at baseline was not associated with CVD in both two cohorts. In subgroup analyses, results were generally consistent with the main analysis.

Conclusions

Poor glycemic control in the early stage of T2D increased later CVD risk in Chinese adults with newly diagnosed T2D. Compared to non-users, this association was smaller and non-significant in patients receiving SGLT-2i/GLP-1RA during the early stage of T2D, indicating early use of these drugs may have the potential to mitigate legacy effects of hyperglycemia.
Characterization of oxytocin and vasopressin receptors in the Southern giant pouched rat and comparison to other rodents
Authors: Freeman Angela R. , Arenas Samanta , Lee Danielle N. , Singh Bhupinder , Ophir Alexander G.
Published: May 2024

Vasopressin and oxytocin are well known and evolutionarily ancient modulators of social behavior. The distribution and relative densities of vasopressin and oxytocin receptors are known to modulate the sensitivity to these signaling molecules. Comparative work is needed to determine which neural networks have been conserved and modified over evolutionary time, and which social behaviors are commonly modulated by nonapeptide signaling. To this end, we used receptor autoradiography to determine the distribution of vasopressin 1a and oxytocin receptors in the Southern giant pouched rat (Cricetomys ansorgei) brain, and to assess the relative densities of these receptors in specific brain regions. We then compared the relative receptor pattern to 23 other species of rodents using a multivariate ANOVA. Pouched rat receptor patterns were strikingly similar to hamsters and voles overall, despite the variation in social organization among species. Uniquely, the pouched rat had dense vasopressin 1a receptor binding in the caudate-putamen (i.e., striatum), an area that might impact affiliative behavior in this species. In contrast, the pouched rat had relatively little oxytocin receptor binding in much of the anterior forebrain. Notably, however, oxytocin receptor binding demonstrated extremely dense binding in the bed nucleus of the stria terminalis, which is associated with the modulation of several social behaviors and a central hub of the social decision-making network. Examination of the nonapeptide system has the potential to reveal insights into species-specific behaviors and general themes in the modulation of social behavior.
Intratumoral delivery of immunotherapy to treat breast cancer: current development in clinical and preclinical studies
Authors: Mantooth Siena M. , Abdou Yara , Saez-Ibañez Ana Rosa , Upadhaya Samik , Zaharoff David A.
Published: May 2024

Breast cancer poses one of the largest threats to women’s health. Treatment continues to improve for all the subtypes of breast cancer, but some subtypes, such as triple negative breast cancer, still present a significant treatment challenge. Additionally, metastasis and local recurrence are two prevalent problems in breast cancer treatment. A newer type of therapy, immunotherapy, may offer alternatives to traditional treatments for difficult-to-treat subtypes. Immunotherapy engages the host’s immune system to eradicate disease, with the potential to induce long-lasting, durable responses. However, systemic immunotherapy is only approved in a limited number of indications, and it benefits only a minority of patients. Furthermore, immune related toxicities following systemic administration of potent immunomodulators limit dosing and, consequently, efficacy. To address these safety considerations and improve treatment efficacy, interest in local delivery at the site of the tumor has increased. Numerous intratumorally delivered immunotherapeutics have been and are being explored clinically and preclinically, including monoclonal antibodies, cellular therapies, viruses, nucleic acids, cytokines, innate immune agonists, and bacteria. This review summarizes the current and past intratumoral immunotherapy clinical landscape in breast cancer as well as current progress that has been made in preclinical studies, with a focus on delivery parameters and considerations.
Discovery of biomarkers in the psoriasis through machine learning and dynamic immune infiltration in three types of skin lesions
Authors: Zhou Xiao , Zhou Han , Luo Xin , Wu Rui-Fang
Published: May 2024

Introduction

Psoriasis is a chronic skin disease characterized by unique scaling plaques. However, during the acute phase, psoriatic lesions exhibit eczematous changes, making them difficult to distinguish from atopic dermatitis, which poses challenges for the selection of biological agents. This study aimed to identify potential diagnostic genes in psoriatic lesions and investigate their clinical significance.

Methods

GSE182740 datasets from the GEO database were analyzed for differential analysis; machine learning algorithms (SVM-RFE and LASSO regression models) are used to screen for diagnostic markers; CIBERSORTx is used to determine the dynamic changes of 22 different immune cell components in normal skin lesions, psoriatic non-lesional skin, and psoriatic lesional skin, as well as the expression of the diagnostic genes in 10 major immune cells, and real-time quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry are used to validate results.

Results

We obtained 580 differentially expressed genes (DEGs) in the skin lesion and non-lesion of psoriasis patients, 813 DEGs in mixed patients between non-lesions and lesions, and 96 DEGs in the skin lesion and non-lesion of atopic dermatitis, respectively. Then 144 specific DEGs in psoriasis via a Veen diagram were identified. Ultimately, UGGT1, CCNE1, MMP9 and ARHGEF28 are identified for potential diagnostic genes from these 144 specific DEGs. The value of the selected diagnostic genes was verified by receiver operating characteristic (ROC) curves with expanded samples. The the area under the ROC curve (AUC) exceeded 0.7 for the four diagnosis genes. RT-qPCR results showed that compared to normal human epidermis, the expression of UGGT1, CCNE1, and MMP9 was significantly increased in patients with psoriasis, while ARHGEF28 expression was significantly decreased. Notably, the results of CIBERSORTx showed that CCNE1 was highly expressed in CD4+ T cells and neutrophils, ARHGEF28 was also expressed in mast cells. Additionally, CCNE1 was strongly correlated with IL-17/CXCL8/9/10 and CCL20. Immunohistochemical results showed increased nuclear expression of CCNE1 in psoriatic epidermal cells relative to normal.

Conclusion

Based on the performance of the four genes in ROC curves and their expression in immune cells from patients with psoriasis, we suggest that CCNE1 possess higher diagnostic value.
Case report: Donor-derived CLL-1 chimeric antigen receptor T-cell therapy for relapsed/refractory acute myeloid leukemia bridging to allogeneic hematopoietic stem cell transplantation after remission
Authors: Miao Xiaojuan , Shuai Yanrong , Han Ying , Zhang Nan , Liu Yilan , Yao Hao , Wang Xiao , He Guangcui , Chen Dan , Fan Fangyi , Chang Alex H. , Su Yi , Yi Hai
Published: May 2024

Background

Explore the efficacy and safety of donor-derived CLL-1 chimeric antigen receptor T-cell therapy (CAR-T) for relapsed/refractory acute myeloid leukemia (R/R AML) bridging to allogeneic hematopoietic stem cell transplantation (allo-HSCT) after remission.

Case presentation

An adult R/R AML patient received an infusion of donor-derived CLL-1 CAR-T cells, and the conditioning regimen bridging to allo-HSCT was started immediately after remission on day 11 after CAR-T therapy upon transplantation. Then, routine post-HSCT monitoring of blood counts, bone marrow (BM) morphology, flow cytometry, graft-versus-host disease (GVHD) manifestations, and chimerism status were performed.

Result

After CAR-T therapy, cytokine release syndrome was grade 1. On day 11 after CAR-T therapy, the BM morphology reached complete remission (CR), and the conditioning regimen bridging to allo-HSCT started. Leukocyte engraftment, complete donor chimerism, and platelet engraftment were observed on days +18, +23, and +26 post-allo-HSCT, respectively. The BM morphology showed CR and flow cytometry turned negative on day +23. The patient is currently at 4 months post-allo-HSCT with BM morphology CR, negative flow cytometry, complete donor chimerism, and no extramedullary relapse/GVHD.

Conclusion

Donor-derived CLL-1 CAR-T is an effective and safe therapy for R/R AML, and immediate bridging to allo-HSCT after remission may better improve the long-term prognosis of R/R AML.
cGAS-STING signaling in cardiovascular diseases
Authors: Zhang Qianxin , Shen Lijuan , Ruan Hongbiao , Huang Zhouqing
Published: May 2024

Sterile inflammation, characterized by a persistent chronic inflammatory state, significantly contributes to the progression of various diseases such as autoimmune, metabolic, neurodegenerative, and cardiovascular disorders. Recent evidence has increasingly highlighted the intricate connection between inflammatory responses and cardiovascular diseases, underscoring the pivotal role of the Stimulator of Interferon Genes (STING). STING is crucial for the secretion of type I interferon (IFN) and proinflammatory cytokines in response to cytosolic nucleic acids, playing a vital role in the innate immune system. Specifically, research has underscored the STING pathway involvement in unregulated inflammations, where its aberrant activation leads to a surge in inflammatory events, enhanced IFN I responses, and cell death. The primary pathway triggering STING activation is the cyclic GMP-AMP synthase (cGAS) pathway. This review delves into recent findings on STING and the cGAS-STING pathways, focusing on their regulatory mechanisms and impact on cardiovascular diseases. It also discusses the latest advancements in identifying antagonists targeting cGAS and STING, and concludes by assessing the potential of cGAS or STING inhibitors as treatments for cardiovascular diseases.
Geriatric nutritional risk index and controller nutritional status score before metastatic first-line chemotherapy predict survival in patients over 70 years of age with metastatic bladder cancer
Authors: Balçık Onur Yazdan , Demir Bilgin , Ilhan Yusuf , Akagündüz Baran
Published: May 2024

Introduction

Several prognostic factors have been identified in patients with metastatic bladder cancer (BC). As it is known, older adult patients are prone to nutritional deficiency. The knowledge about nutrition and impact on survival in older patients with metastatic bladder cancer is missing. It is necessary to specifically examine this population. Because timely interventions can make a positive impact on this patients population. This retrospective study aimed to evaluate the prognostic effect of the Geriatric Nutritional Risk Index (GNRI), Controller Nutritional Status (CONUT) score and Prognostic Nutritional Index (PNI) before first-line chemotherapy in the metastatic stage in patients with metastatic bladder cancer over 70.

Participants and methods

Patients over 70 with pathologically confirmed denovo metastatic or recurrent metastatic bladder cancer were included in the study. Patients with infections diagnosed at the time of diagnosis, autoimmune diseases or history of steroid use were excluded. Since our population consists of a specific age group with a specific cancer, we found a new cut-off value by performing ROC analysis to ensure optimal sensitivity and specificity in terms of progression. Low GNRI value was related with poor nutritional status. Low PNI value was related with poor nutritional status and high CONUT score was related with poor nutritional status. Factors predicting overall survival (OS) and Progression-Free Survival (PFS) were assessed using both univariate and multivariate Cox proportional hazards analyses.

Results

106 patients were included in the study and the average age was 75.5 years. In the GNRI-Low group, PFS was significantly shorter than that in the GNRI-High group [HR (95% CI) = 57.1 (12.8–255.5), (p < 0.001)]. Among those with a low-CONUT score, PFS was found to be longer than that in the high-CONUT group [HR (95% CI) = 1.7 (1.0–3.0), (p = 0.039)]. The median PFS of the PNI-Low group wasn’t significantly shorter than that of the PNI-High group [HR (95% CI) = 1.8 (0.5–6.2), (p = 0.359)].

Conclusion

Our study suggests that the GNRI and CONUT scores are useful for predicting survival in patients over 70 years of age with BC.
Carbon nanotubes: a novel innovation as food supplements and biosensing for food safety
Authors: Masood Maazallah , Albayouk Tala , Saleh Na'il , El-Shazly Mohamed , El-Nashar Heba A. S.
Published: May 2024

Recently, nanotechnology has emerged as an extensively growing field. Several important fabricated products including Carbon nanotubes (CNTs) are of great importance and hold significance in several industrial sectors, mainly food industry. Recent developments have come up with methodologies for the prevention of health complications like lack of adequate nutrition in our diet. This review delves deeper into the details of the food supplementation techniques and how CNTs function in this regard. This review includes the challenges in using CNTs for food applications and their future prospects in the industry. Food shortage has become a global issue and limiting food resources put an additional burden on the farmers for growing crops. Apart from quantity, quality should also be taken into consideration and new ways should be developed for increasing nutritional value of food items. Food supplementation has several complications due to the biologically active compounds and reaction in the in vivo environment, CNTs can play a crucial role in countering this problem through the supplementation of food by various processes including; nanoencapsulation and nanobiofortification thus stimulating crop growth and seed germination rates. CNTs also hold a key position in biosensing and diagnostic application for either the quality control of the food supplements or the detection of contagions like toxins, chemicals, dyes, pesticides, pathogens, additives, and preservatives. Detection such pathogens can help in attaining global food security goal and better production and provision of food resources. The data used in the current review was collected up to date as of March 31, 2024 and contains the best of our knowledge. Data collection was performed from various reliable and authentic literatures comprising PubMed database, Springer Link, Scopus, Wiley Online, Web of Science, ScienceDirect, and Google Scholar. Research related to commercially available CNTs has been added for the readers seeking additional information on the use of CNTs in various economic sectors.
Repeat biopsy versus initial biopsy in terms of complication risk factors and clinical outcomes for patients with non-small cell lung cancer: a comparative study of 113 CT-guided needle biopsy of lung lesions
Authors: Wang Yangyang , Zhang Yongyuan , Ren Nana , Li Fangting , Lu Lin , Zhao Xin , Zhou Zhigang , Gao Mengyu , Wang Meng
Published: May 2024

Objectives

The safety and feasibility of repeat biopsy after systemic treatment for non-small cell lung cancer have received extensive attention in recent years. The purpose of this research was to compare complication rates between initial biopsy and rebiopsy in non-small cell lung cancer patients with progressive disease and to assess complication risk factors and clinical results after rebiopsy.

Methods

The study included 113 patients initially diagnosed with non-small cell lung cancer who underwent lung biopsy at initial biopsy and rebiopsy after progression while on epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and/or chemotherapy from January 2018 to December 2021. We compared the incidence of complications between the initial biopsy and rebiopsy and analyzed the predictors factors that influenced complications in patients who underwent rebiopsy.

Results

The successful rate of rebiopsy was 88.5% (100/113). With the exception of two cases where lung adenocarcinoma changed into small cell lung cancer with gefitinib treatment, 98 individuals retained their initial pathological type. The secondary EGFR T790M mutation accounts for 55.6% of acquired resistance. The total number of patients with complications in initial biopsy was 25 (22.1%) and 37 (32.7%) in the rebiopsy. The incidence of pulmonary hemorrhage increased from 7.1% at the initial biopsy to 10.6% at rebiopsy, while the incidence of pneumothorax increased from 14.2% to 20.4%. Compared with the initial biopsy, the incidence of overall complications, parenchymal hemorrhage, and pneumothorax increased by 10.6%, 3.5%, and 6.2%, respectively. In all four evaluations (pneumorrhagia, pneumothorax, pleural reaction, and overall complication), there were no significant differences between the rebiopsy and initial biopsy (all p > 0.05). The multivariate logistic regression analysis suggested that male sex (odds ratio [OR] = 5.064, p = 0.001), tumor size ≤ 2 cm (OR = 3.367, p = 0.013), EGFR-TKIs with chemotherapy (OR = 3.633, p =0.023), and transfissural approach (OR = 7.583, p = 0.026) were independent risk factors for overall complication after rebiopsy.

Conclusion

Compared with the initial biopsy, the complication rates displayed a slight, but not significant, elevation in rebiopsy. Male sex, tumor size ≤ 2 cm, transfissural approach, and EGFR-TKIs combined with chemotherapy were independent risk factors for rebiopsy complications.
Prompt gamma imaging system in particle therapy: a mini-review
Authors: Cheon Bo-Wi , Min Chul Hee
Published: May 2024

Accurate in-vivo verification of beam range and dose distribution is crucial for the safety and effectiveness of particle therapy. Prompt gamma (PG) imaging, as a method for real-time verification, has gained prominence in this area. Currently, several PG imaging systems are under development, including gamma electron vertex imaging (GEVI), the Compton camera, the slit camera, and the multi-array type collimator camera. However, challenges persist in dose prediction accuracy, largely due to patient positioning uncertainty and anatomical changes. Although each system demonstrates potential in verifying PG range, further improvements in detection efficiency, spatial resolution, background reduction, and integration into clinical workflows are essential.
Insensitivity of Tc to the residual resistivity in high-Tc cuprates and the tale of two domes
Authors: Juskus D. , Ayres J. , Nicholls R. , Hussey N. E.
Published: May 2024

One of the few undisputed facts about hole-doped high-Tc cuprates is that their superconducting gap Δ has d-wave symmetry. According to ‘dirty’ d-wave BCS theory, even structural (non-magnetic) disorder can suppress Δ, the transition temperature Tc and the superfluid density ρs. The degree to which the latter is affected by disorder depends on the nature of the scattering. By contrast, Tc is only sensitive to the total elastic scattering rate (as estimated from the residual resistivity ρ0) and should follow the Abrikosov-Gor’kov pair-breaking formula. Here, we report a remarkable robustness of Tc in a set of Bi2201 single crystals to large variations in ρ0. We also survey an extended body of data, both recent and historical, on the LSCO family which challenge key predictions from dirty d-wave theory. We discuss the possible causes of these discrepancies, and argue that either we do not understand the nature of disorder in cuprates, or that the dirty d-wave scenario is not an appropriate framework. Finally, we present an alternative (non-BCS) scenario that may account for the fact that the superconducting dome in Tl2201 extends beyond that seen in Bi2201 and LSCO and suggest ways to test the validity of such a scenario.
The effect of physical activity on anxiety symptoms among children and adolescents with mental health disorders: a research brief
Authors: Anker Ella Aase , Bøe Sture Svanhild E. , Hystad Sigurd William , Kodal Arne
Published: May 2024

Background

Anxiety is prevalent among children and adolescents (termed youths), and leads to reduced quality of life, disability, loss of education and reduced life-span. Physical activity has shown promising effects on symptoms of anxiety in adult populations, and an increasing amount of research has also demonstrated some effect in youth. However, physical activity is not widely used in youth mental health care, and research is very limited.

Methods/design

This single arm, pre-post study explores the effect of a manualized physical activity-based 14-session intervention termed Confident, Active and Happy Youth. Participants are youth attending specialized mental health care (N=51, M age = 13.4, SD = 2.2). Changes in anxiety symptoms are examined using mixed models with residual maximum likelihood (REML). The potential effect of anxiety subtype differences, participant age, comorbidity, and time spent in out-patient care are explored.

Results

Youths did not report any effect on anxiety symptoms after participation in CAHY, however, their parents report a significant reduction in youth’s anxiety symptoms in general (b = -0.11, 95%, CI: -0.21 to -0.01) and specifically for social phobia (b = -0.19, 95% CI: -0.35 to -0.03). Age and comorbidity showed no significant effect on anxiety symptoms post treatment. Prior treatment time in youth mental health care demonstrated inconclusive results.

Conclusion

The study finds initial evidence of symptomatic change in a clinical population of youth’s receiving a physical activity-based intervention. Our research provides preliminary support for physical activity as a supplementary treatment method for mental health disorders among youths.

Clinical Trial Registration

clinicaltrials.gov, NCT05049759
Serum levels of neurotensin, pannexin-1, and sestrin-2 and the correlations with sleep quality or/and cognitive function in the patients with chronic insomnia disorder
Authors: Su Ai-Xi , Ma Zi-Jie , Li Zong-Yin , Li Xue-Yan , Xia Lan , Ge Yi-Jun , Chen Gui-Hai
Published: May 2024

Objectives

To examine serum concentrations of neurotensin, pannexin-1 and sestrin-2, and their correlations with subjective and objective sleep quality and cognitive function in the patients with chronic insomnia disorder (CID).

Methods

Sixty-five CID patients were enrolled continuously and fifty-six good sleepers in the same period were served as healthy controls (HCs). Serum levels of neurotensin, pannexin-1 and sestrin-2 were measured by enzyme-linked immunosorbent assays. Sleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI) and polysomnography, and mood was evaluated by 17-item Hamilton Depression Rating Scale. General cognitive function was assessed with the Chinese-Beijing Version of Montreal Cognitive Assessment and spatial memory was evaluated by Blue Velvet Arena Test (BVAT).

Results

Relative to the HCs, the CID sufferers had higher levels of neurotensin (t=5.210, p<0.001) and pannexin-1 (Z=−4.169, p<0.001), and lower level of sestrin-2 (Z=−2.438, p=0.015). In terms of objective sleep measures, pannexin-1 was positively associated with total sleep time (r=0.562, p=0.002) and sleep efficiency (r=0.588, p=0.001), and negatively with wake time after sleep onset (r=−0.590, p=0.001) and wake time (r=−0.590, p=0.001); sestrin-2 was positively associated with percentage of rapid eye movement sleep (r=0.442, p=0.016) and negatively with non-rapid eye movement sleep stage 2 in the percentage (r=−0.394, p=0.034). Adjusted for sex, age and HAMD, pannexin-1 was still associated with the above objective sleep measures, but sestrin-2 was only negatively with wake time (r=−0.446, p=0.022). However, these biomarkers showed no significant correlations with subjective sleep quality (PSQI score). Serum concentrations of neurotensin and pannexin-1 were positively associated with the mean erroneous distance in the BVAT. Adjusted for sex, age and depression, neurotensin was negatively associated with MoCA score (r=−0.257, p=0.044), pannexin-1 was positively associated with the mean erroneous distance in the BVAT (r=0.270, p=0.033).

Conclusions

The CID patients had increased neurotensin and pannexin-1 and decreased sestrin-2 in the serum levels, indicating neuron dysfunction, which could be related to poor sleep quality and cognitive dysfunction measured objectively.
“Swipe & slice”: decoding digital struggles with non-suicidal self-injuries among youngsters
Authors: Orsolini Laura , Reina Salvatore , Longo Giulio , Volpe Umberto
Published: May 2024

Introduction

Nonsuicidal-self-injury (NSSI)-related content recently emerged on social networking sites (SNS), despite its relationship with NSSI conducts is still unclear.

Methods

Hence, the current population-based cross-sectional study investigated the interplay between SNS use, NSSI content engagement, risky social media challenges (RSMCs), in a sample of 404 young adults (aged 18–24), focusing on the influence of problematic social media use (PSMU) and fear of missing out (FoMO).

Results

Around 51.5% of the samplewas engaged inNSSI-related contents on SNS, being mostly females (p<0.001), younger (p=0.005), transgender people and nonbinary people (p=0.030) and those who displayed higher PSMU (p<0.001) or FoMO (p=0.031). Around 66.2% of the sample currently practice NSSIs, predominantly among females (p<0.001), those using BeReal (p=0.012), actively looking for NSSIrelated contents on SNS (p<0.001) to be part of a group (p=0.0025) or learn how to practice NSSI (p=0.025). PSMU (p<0.001) and FoMO (p<0.001) emerged as significant predictors of NSSI content engagement, particularly among active seekers. NSSI conducts were significantly predicted by FoMO (p<0.001) and Snapchat (p=0.044), while negatively predicted by male sex (p<0.001), higher educational level (p=0.019) and age at which NSSI-related contents were firstly looked for (p=0.028).

Discussion

These findings underline the need to implement preventivepolicies and targeted interventions to monitor NSSI-related contents on SNS, the impact of PSMU and FoMO on NSSI, particularly among youngsters.
Point-of-care testing: a critical analysis of the market and future trends
Authors: Khan Abdul Raffay , Hussain Wasif Latif , Shum Ho Cheung , Hassan Sammer Ul
Published: May 2024

Point-of-care testing (POCT) involves conducting diagnostic tests outside the laboratory. These tests are utilized for their quick and reliable results in detecting chronic diseases and acute infections. We examined the historical market value trends of the POCT industry and projected its future growth. POCT devices offer several advantages, such as portability, no specific storage requirements, and simplicity of use. However, issues such as inaccurate results can reduce demand for POCT compared to traditional laboratory testing alternatives. While the benefits of POCT are clear, it’s important to acknowledge the challenges. The accuracy of POCT devices can be compromised due to factors such as user error, environmental conditions, and limitations in technology. Furthermore, the cost-effectiveness of these devices is often a concern, particularly in resource-limited settings. The regulatory landscape for POCT is also complex and varies by region, which can pose challenges for manufacturers and end-users. Improvements in POCT devices’ sensitivity, specificity, cost, and turnaround time for test results could enhance their utility. Enhancements to a POCT device should be considered if they are economically viable and lead to a significant increase in demand. Our financial analysis of the POCT market revealed a positive growth trend. We identified potential areas for growth that could help the industry progress and expand in line with its projected growth in the coming years. The industry could focus on integrating intelligent technologies into POCT devices and collaborating with the innovative technology sector to increase revenue. It could also develop more sensitive and accurate POCT devices for non-communicable diseases. Another potential area of growth is in diseases that require continuous patient monitoring but where conventional clinical testing is time-consuming. Enhancing the POCT devices used in these areas could revolutionize medical diagnosis and potentially save many lives, provided they meet clinical standards.
Resource endowment and sustainable soil fertility management strategies in maize farming systems in northern Benin
Authors: Tovihoudji Pierre G. , Sossa Elvire Line , Egah Janvier , Agbangba Emile C. , Akponikpè P. B. Irenikatché , Yabi Jacob A.
Published: May 2024

Introduction

Managing soil fertility remains one of the major concerns of smallholder farmers in Sub-Saharan Africa (SSA). In order to understand the adoption potential of recommended practices to smallholders, this study aimed to characterize the resource availability, allocation and use patterns, and the soil fertility management practices in the maize farming system in northern Benin.

Methods

A survey was conducted with 262 households randomly selected across three municipalities from three agro-ecological zones. Focus groups discussions and individual interviews were conducted with the household heads using an interview guide and a structured questionnaire respectively. The main data collected included (a) the socio-economic characteristics of households, (b) the main farm type and their characteristics and (c) the current soil fertility management strategies and the rationale behind.

Results and discussion

The main soil fertility practices included the use of mineral fertilizer, manure, and crop residues application to plots. As a general trend, the rates of fertilizers applied by farmers [on average 132 ± 8.5 and 59 ± 5.8 kg ha−1 of Nitrogen-Phosphorus-Potassium (NPK) and urea] were below those recommended or required to ensure optimal maize yields. Five farm types corresponding to different resource endowments or wealth classes were identified. The scarce resource farms owned by the majority of poorer farmers use only small amounts of manure and fertilizer in their fields. Qualitative analysis indicated that farms have different constraints and opportunities to adopt newly proposed soil fertility management recommendations.

Conclusion

Extension services and decision makers must target specific interventions for appropriation and sustainability of technologies to resource mostly the smallholder farmers.
RuBisCO: a sustainable protein ingredient for plant-based foods
Authors: Nawaz Malik Adil , Kasote Deepak M. , Ullah Najeeb , Usman Kamal , Alsafran Mohammed
Published: May 2024

Ribulose bisphosphate carboxylase/oxygenase (RuBisCO), is a widely available plant protein receiving great interest because of its nutritional and functional properties. It can be a valuable source of protein for vegetarians. However, it has not received commercial significance due to the lack of a streamlined extraction process at the industrial scale, including its potential health benefits. In this review, we have summarized the literature on the biochemical characteristics of RuBisCO and compared its nutritional value with other plant proteins, as well as highlighted its digestibility, allergic traits, and potential health benefits. Moreover, the existing literature on the extraction of RuBisCO, associated challenges in industrial-scale RuBisCO purification, and recent innovations that occurred in this context are compiled. We believe this review will provide insights into RuBisCO’s nutritional value and techno-functionality. Altogether, RuBisCO can be a sustainable source of protein in the future, especially for vegetarians.
The clinical application of V-Y advanced flap pedicled with freestyle perforator flap for repairing small range defects in the anterior knee region
Authors: Qian Da , Jin Lijie , Huang Guoxin , Dai Ping , Li Dong , Lu Hui , Xu Ming , Wang Ke , Zhong Xian , Xu Xiaochen , Zhang Jianchao , Yu Bin
Published: May 2024

Introduction

This study aims to investigate the clinical efficacy of V-Y advanced flap pedicled with freestyle perforator flap for repairing small range defects in the anterior knee region.

Methods

8 patients with skin and soft tissue defect/necrosis in the anterior knee area admitted to the Changshu No.1 People's Hospital from January 2021 to January 2022 were selected, with a defect range of 4 cm × 3 cm–9 cm × 6 cm, designed a V-Y advanced flap pedicled with freestyle perforator flap to repair the wound in the anterior knee area. Adjust the size and position of the flap according to the number and position of perforating branches found during the surgery, with a cutting area of 6 cm × 5 cm–14 cm × 10 cm and the supply area was directly pulled and sutured.

Results

4 patients were repaired by flaps pedicled with 2 perforating branches, 2 patients were repaired by flaps pedicled with 1 perforating branch and 2 patients were repaired by flaps pedicled with 3 perforating branches. 4 patients were repaired by flaps pedicled with 2 perforating branches, 2 patients were repaired by flaps pedicled with 1 perforating branch and 2 patients were repaired by flaps pedicled with 3 perforating branches. All flaps survived and following up for 6-15 months, the blood supply, appearance, and color of the flap were satisfactory, and the functions of knee joint flexion and extension were well preserved.

Discussion

The V-Y advancement flap pedicled with freestyle perforator flap has the advantages of reliable blood supply, simple surgical operation, texture and thickness similar to the skin of the anterior knee area, and direct suture of the donor area. It is a perforator flap with good repair effect for small scale defects in the anterior knee area.
Sample strategies for the assessment of the apparent diffusion coefficient in single large intracranial space-occupying lesions of dogs and cats
Authors: Chan Tatjana , Richter Henning , Del Chicca Francesca
Published: May 2024

Diffusion-weighted imaging is increasingly available for brain investigation. Image interpretation of intracranial space-occupying lesions often includes the derived apparent diffusion coefficient (ADC) analysis. In human medicine, ADC can help discriminate between benign and malignant lesions in intracranial tumors. This study investigates the difference in ADC values depending on the sample strategies of image analysis. MRI examination, including diffusion-weighted images of canine and feline patients presented between 2015 and 2020, were reviewed retrospectively. Patients with single, large intracranial space-occupying lesions were included. Lesions homogeneity was subjectively scored. ADC values were calculated using six different methods of sampling (M1–M6) on the ADC map. M1 included as much as possible of the lesion on a maximum of five consecutive slices; M2 included five central and five peripheral ROIs; M3 included a single ROI on the solid part of the lesion; M4 included three central ROIs on one slice; M5 included three central ROIs on different slices; and M6 included one large ROI on the entire lesion. A total of 201 animals of various breeds, genders, and ages were analyzed. ADC values differed significantly between M5 against M2 (peripheral) (p < 0.001), M5 against M6 (p = 0.009), and M4 against M2 (peripheral) (p = 0.005). When lesions scored as homogeneous in all sequences were excluded, an additional significant difference in three further sampling methods was present (p < 0.005). ADC of single, large, intracranial space-occupying lesions differed significantly in half of the tested methods of sampling. Excluding homogeneous lesions, additional significant differences among the sampling methods were present. The obtained results should increase awareness of the variability of the ADC, depending on the sample strategies used.
Case report: Radiofrequency-induced thermal burn injury in a dog after magnetic resonance imaging
Authors: Lichtenauer Esther A. , Santifort Koen M. , Bergknut Niklas , van Soens Iris , Beukers Martijn , Carrera Ines
Published: May 2024

A 10-year-old male Shar-Pei was referred for lethargy and proprioceptive deficits of the left thoracic limb. An magnetic resonance imaging (MRI) examination of the cervical spinal column and the brain was performed. The MRI examination of the brain was normal. A left-sided C3-C4 intervertebral disc extrusion with spinal cord compression was diagnosed. Medical treatment was elected. Within a week after the MRI examination, the dog presented with deep partial-thickness skin burn wounds in both axillae. Since the specific absorption rate had not exceeded the safety limits during any of the scans and no other procedures or circumstances were identified that could possibly have resulted in burn injuries, the thermal burn injuries were diagnosed as radiofrequency (RF) burns. The wounds healed by secondary intent over the next month. RF burns are the most reported complication in humans undergoing MRI but have not been reported in veterinary patients. Clinicians and technicians should consider the potential risk for RF burns in veterinary patients and take precautions regarding positioning of the patient and take notice of any signs of burn injury when performing follow-up examinations.
Impact of the War in Ukraine on the Ability of Children to Recognize Basic Emotions
Authors: Loshenko Oleksandra , Palíšek Petr , Straka Ondřej , Jabůrek Michal , Portešová Šárka , Ševčíková Anna
Published: May 2024

Objectives

This study assessed emotion recognition skills in school-age children in wartime conditions in Ukraine.

Methods

An online survey based on the concept of basic emotions was administrated to a sample of 419 schoolchildren from Ukraine and a control group of 310 schoolchildren from the Czech Republic, aged 8 to 12.

Results

There is no difference in judging the intensity of anger and fear by Ukrainian children, compared with the control group. There is no evidence that the emotions of anger, fear, and sadness were better recognized in the Ukrainian group. Children from Ukraine were better at recognizing positive emotions than Czech children.

Conclusion

Increased risks of threats and wartime experience do not impair the accuracy of identification of emotions like fear or the assessment of intensity of basic emotions by children who experience war in Ukraine. Still, it is important to continue studying the long-term consequences of military conflicts in order to deepen the understanding of their impact on human mental functioning.
Assessment of Passive Solar Heating Systems’ Energy-Saving Potential across Varied Climatic Conditions: The Development of the Passive Solar Heating Indicator (PSHI)
Authors: Mo Wensheng , Zhang Gaochuan , Yao Xingbo , Li Qianyu , DeBacker Bart Julien
Published: May 2024

This study aims to evaluate the energy-saving potential of passive solar heating systems in diverse global climates and introduce a new indicator, the passive solar heating indicator (PSHI), to enhance the efficiency of building designs. By collecting climate data from 600 cities worldwide through a simulation model, the present study employs polynomial regression to analyze the impact of outdoor temperature and solar radiation intensity on building energy savings. It also uses K-means cluster analysis to scientifically categorize cities based on their energy-saving potential. The findings underscore the benefits of both direct and indirect solar heating strategies in different climates. Significantly, the PSHI shows superior predictive accuracy and applicability over traditional indices, such as the irradiation temperature difference ratio (ITR) and the irradiation degree hour ratio (C-IDHR), especially when outdoor temperatures are close to indoor design temperatures. Moreover, the application of a cluster analysis provides hierarchical guidance on passive heating designs globally, paving the way for more accurate and customized energy-efficient building strategies.
Martian Regolith Simulant-Based Geopolymers with Lithium Hydroxide Alkaline Activator
Authors: Vitse Jasper , Li Jiabin , Boehme Luc , Briers Rudy , Vandeginste Veerle
Published: May 2024

As humanity envisions the possibility of inhabiting Mars in the future, the imperative for survival in the face of its challenging conditions necessitates the construction of protective shelters to mitigate the effects of radiation exposure and the absence of atmospheric pressure. The feasibility of producing geopolymers using the Martian regolith simulant MGS-1 (as precursor) for potential building and infrastructure projects on Mars in the future is investigated in this paper. Various alkaline activators, such as sodium hydroxide (NaOH), lithium hydroxide (LiOH·H2O) and sodium silicate (Na2SiO3), are employed to investigate their efficiency in activating the precursor. The influence of alkali type and concentration on the mechanical performance of the synthesized geopolymers is examined. Geopolymer samples are oven-cured for 7 days at 70 °C before a compressive strength test. It is found that through the hybrid use of LiOH·H2O and NaOH with optimal concentrations, metakaolin and milled MGS-1 as precursors, geopolymer mixtures with a compressive strength of 30 ± 2 MPa can be developed. The present test results preliminarily demonstrate the potential of Martian regolith simulant-based geopolymers as suitable construction and building materials for use on Mars.
Effect of U-Shaped Metallic Dampers on the Seismic Performance of Steel Structures based on Endurance-Time Analysis
Authors: Farajiani Farhad , Elyasigorji Farzaneh , Elyasigorji Sina , Moradi Mohammad Javad , Farhangi Visar
Published: May 2024

Seismic performance of steel moment-resisting frames is investigated through the incorporation of U-shaped metallic dampers. The primary objective is to assess the effectiveness of these dampers in mitigating seismic responses by utilizing various analysis techniques. Two representative structural configurations (5 and 10-story) are studied in both damped and undamped states to reveal the impact of dampers on seismic response reduction. The study utilizes the endurance time analysis (ETA) method, known for its efficiency in evaluating structural seismic performance. To validate the analysis results, a benchmark comparison is made through nonlinear time history analysis (NTHA). Incremental dynamic analysis (IDA) is also conducted to assess structures’ intensity measures with respect to their damage intensity index. The findings demonstrate that U-shaped metallic dampers substantially reduce inter-story drift and story shear forces. Importantly, a close alignment between the results obtained from ETA and NTHA underscores the reliability of the former in assessing seismic performance with supplemental damping devices.
Effect of Moisture Content and Wet–Dry Cycles on the Strength Properties of Unsaturated Clayey Sand
Authors: Wang Chuan , Yang Weimin , Zhang Ning , Wang Senwei , Ma Chuanyi , Wang Meixia , Zhang Zhiyuan
Published: May 2024

Based on the actual situation of the project on the Weihai–Yanhai Expressway section of Rongwu Expressway, the effects of water content change and the dry–wet cycle on the mechanical behavior of unsaturated clayey sandy soil were analyzed in this study. In this study, ventilated undrained triaxial shear tests were carried out on unsaturated clayey sandy soils with different water contents (6%, 8%, 10%, 12%, 14% and 16%). Concurrently, the soil samples were subjected to three distinct wet and dry cycle pathways (2~22%, 2~12%, and 12~22%) to gain an understanding of how the mechanical features of the soil changed under the different conditions. The test findings demonstrate that when the water content increases, the unsaturated clayey sandy soil’s cohesiveness and shear strength diminish. The strength of shear decline exhibits a pattern of first being quick, followed by sluggish. The strength of shear and cohesiveness of clayey sandy soil declined under the influence of the dry and wet cycles, with the first cycle primarily affecting variations in cohesiveness and strength of shear. Furthermore, the strength of shear and cohesiveness of clayey sandy soil diminish more with increasing wet and dry cycle amplitude and upper water content limits. Lastly, the drying shrinkage and hygroscopic expansion of clay particles in clayey sandy soils during wet and dry cycles are not significant, resulting in less structural damage and deterioration of the mechanical properties of the soils. The study’s findings have a significant impact on the durability of roadbeds made of unsaturated clayey sandy soil in both wet and dry situations.