bluuebunny/crossref_metadata_2025 huggingface dataset:
Retour réflexif sur un parcours notionnel
Authors: Coste Daniel
Published: May 2024

Cette contribution propose un retour réflexif sur une longue carrière dans le domaine de la diffusion du français langue étrangère et de la recherche en didactique des langues. Ceci sous la forme d’une sorte de « biographie notionnelle », à l’image de ce qu’on met sous « biographie langagière », et par une interrogation sur des notions et concepts croisés au fil de plusieurs décennies d’activité. Au long de cette trajectoire personnelle inscrite dans des moments historiques, des conjonctures épistémiques et des environnements institutionnels changeants, j’ai tenu à mettre ces notions « en question(s) » et à les examiner et les discuter dans l’instant même ou après coup. Posture consistant à tenir à une certaine distance l’appareil conceptuel dont on fait usage ou qui prédomine dans telle ou telle période. L’examen reste dans le champ même où on intervient et ne s’arme, pour l’essentiel, ni d’instruments d’analyse critique bien définis et aiguisés, ni d’un cadrage épistémologique explicité et affirmé. Positionnement délicat donc, mais assumé comme tel.
Does Frankie Go to Hollywood? From American influence to articulatory phonetics: the singing pronunciation of 1980s pop artists
Authors: Caillol Coline , Ferragne Emmanuel
Published: May 2024

Cet article s’inscrit dans la lignée de l’étude fondatrice de Trudgill sur la prononciation des chansons pop, dans laquelle il constate que certains artistes britanniques comme les Beatles ont tendance à chanter avec un accent que l’on pourrait qualifier d’américain. Avec le temps, cette influence explicite du modèle américain s'est inscrite comme un standard de prononciation dans la musique pop, devenant une variété d’anglais à part entière (Pop Song English ou PSE). L’objectif de ce travail est d’étudier ce phénomène dans le cas de la pop des années 1980, époque qui a marqué un tournant dans l’histoire de la production et de la commercialisation de la musique. Une étude quantitative de la prononciation de mots contenant un /t/ intervocalique, marqueur d’un accent américain (où une réalisation de ce /t/ en battue alvéolaire est considérée comme typiquement américaine par opposition à une occlusive alvéolaire plus britannique), a été réalisée sur une base de données de 350 morceaux choisis aléatoirement parmi les 10 albums les plus vendus de chaque année de la décennie. En dépit d'une certaine variation, la plupart des chanteurs réalisent la majorité de leurs /t/ en battue dans les productions chantées, ce qui n’est pas attesté dans leurs productions parlées. Les arguments socioculturels traditionnels relatifs à l'influence de l'industrie musicale américaine et des genres musicaux nés aux États-Unis sont présentés, étayés par les opinions des artistes eux-mêmes, recueillies dans le cadre d'entretiens disponibles sur internet. Puis, nous esquissons les contours d'une explication complémentaire de nature articulatoire, en examinant la spécificité de la voix chantée et ses contraintes inhérentes de prononciation. Nous posons l'hypothèse selon laquelle l'anglais de la chanson pop est devenu une norme de prononciation également pour des raisons phonétiques et fonctionnelles, bien qu’il reste à démontrer le fondement d’une telle idée de manière expérimentale.
The presentation of self in the Zoom age: insights from pragmatics and cognitive science
Authors: Lapaire Jean-Rémi
Published: May 2024

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La trilogie « chaume-tuile-ardoise » à Bruxelles au bas Moyen Âge : état de la question
Authors: Charruadas Paulo , Sosnowska Philippe
Published: May 2024

Résumé : S’appuyant sur un corpus de textes et de sites archéologiques ainsi que sur l’analyse des réseaux d’échanges, l’article entend proposer un premier bilan de la question des matériaux de couverture à Bruxelles à la fin du Moyen Âge (xiiie-xvie siècles). Il montre l’importance de la triade matérielle constituée par le chaume, la tuile et l’ardoise et éclaire leur évolution contrastée à travers la période, en ville et dans son proche hinterland. Il tente également d’esquisser la spécificité socio-économique de l’usage de l’ardoise. D’une manière générale, il dresse l’inventaire des carences et zones d’ombre qui restent à explorer. Son ambition est avant tout de servir de base à des recherches ultérieures, nécessaires pour améliorer l’état encore partiel des connaissances.
Comparative efficacy analysis of mannitol and hypertonic saline in the management of traumatic brain injury: a scientific exploration of neuroprotective strategies
Authors: Nagaraju Kishore , Lobo Leema , Sharma Manjari
Published: May 2024

In the management of severe traumatic brain injuries (TBIs), controlling intracranial pressure (ICP) is a pivotal therapeutic goal. Historically, mannitol has been the recommended first-line osmotic agent; however, concerns surrounding its use, including hypotension, rebound ICP elevation, and renal toxicity, have prompted a quest for alternative strategies. Hypertonic saline (HS) has emerged as a promising substitute, demonstrating efficacy in reducing ICP without compromising cerebral perfusion. This comprehensive analysis explores the comparative effectiveness of Mannitol and Hypertonic Saline in the context of severe TBIs. While Mannitol has been a longstanding choice, recent attention has shifted towards HS due to its reported superiority in ICP reduction. Concerns associated with mannitol, such as hypotension and rebound ICP, are juxtaposed against the potential advantages offered by HS. The scarcity of clinical studies focusing on TBI-related outcomes, such as patient survival and long-term benefits, is highlighted, underscoring a critical gap in the current knowledge landscape. The review aims to provide a nuanced understanding of the comparative effectiveness of Mannitol and Hypertonic Saline, considering not only ICP control but also broader patient outcomes. By addressing the suitability of these agents in diverse clinical settings, this analysis seeks to guide clinicians in making informed decisions tailored to individual patient needs.
Occupational asthma
Authors: Pahad H.
Published: May 2024

No abstract available.
Acne vulgaris: Grades of severity and treatment options
Authors: Jacyk W.K.
Published: May 2024

Acne is the most common skin condition treated by dermatologists. Acne is a polymorphic disease exhibiting a number of diverse lesions: comedones, papules, pustules, nodules, cysts, sinuses and scars. Despite this diversity, acne can be reduced to a two-stage sequence of events. Firstly an abnormal hypercornification and desquamation in the infundibular segment of the pilosebaceous unit (the infundibulum is the part of the hair follicle from the orifice of the sebaceous gland duct to the opening on the surface) leads to the formation of a comedo, initially without an inflammatory component; and later an inflammatory reaction results in disorganisation of the epithelial capsule.
Leading the Academy - a personal journey
Authors: De Villiers Marietjie
Published: May 2024

No abstract available.
Knowledge and awareness of celiac disease among the dental students
Authors: Kameswari S. , Kavitha S. , Veeraraghavan Vishnu Priya , Gayathri R.
Published: May 2024

Consumption of gluten triggers an autoimmune disease known as celiac disease (CD). This is also referred to as nontropical sprue, celiac sprue, or gluten-sensitive enteropathy. Gluten is a protein present in wheat, barley, rye, and other grains. It is due to gluten that the dough becomes elastic and provides bread its chewy texture. The aim of this study is to assess the awareness and knowledge of CD among dental students. This survey is totally based on CD and its awareness among dental students. A survey was conducted among 100 students who are volunteers underneath. This survey contained questionnaires of CD causes, symptoms, treatment, etc., and the accrued was analyzed using SPSS statistics. The result shows that CD affects mainly the small intestine being chosen by 38.61% of students. The symptoms of CD as chronic diarrhea are chosen by 63.37%. The main cause of the disease is due to gluten chosen by 9.90%. Some of the gluten-free foods are chosen by 22.77% of students. In the Chi-square test, the association between the awareness of CD and students shows that postgraduate (PG) students are more aware than undergraduate (UG) students. However, this is not statistically significant since P > 0.05 (P = 0.088). The correlation graph says that the PGs are more aware than the undergraduates, and UGs have poor knowledge about this disease.
Management of inadequate width of attached gingiva using mucograft
Authors: Navya Paladugu Devi , Rajasekar Arvina
Published: May 2024

Attached gingiva around the teeth is crucial in preserving periodontal health. Plaque development and soft-tissue recession are both prevented by adequate attached gingiva. The processes for harvesting soft-tissue grafts are frequently accompanied by some level of morbidity which results in commercially available xenogeneic collagen matrices. The blood clot is more effectively stabilized by this collagen matrix, which also promotes vascularization. Furthermore, this biomaterial enhances root coverage and keratinized gingiva regeneration in both width and thickness. The purpose of the case report is to increase the width of attached gingiva using Mucograft®. This case report highlights a case scenario where a patient presented with probing depth of 6–8 mm in relation to 24, 25, 26, 27, and 28, Grade I mobility in relation to 25.26, and 1 mm of the width of attached gingiva in relation to 25, 26, and 27. Flap surgery was done and simultaneously vestibular deepening was done in relation to 25, 26, and 27, and mucograft was placed and stabilized. On a 3-month follow-up, probing pocket depth was 3 mm and 4 mm of width of the attached gingiva was seen in 25, 26, and 27. The Mucograft® was beneficial in this clinical case for the purpose of extending the width of the associated gingiva, making it a feasible treatment option for soft-tissue augmentation.
Assessment of independent variables of periodontal disease among selected South Indian population
Authors: Anjum Shamaa , Rajasekar Arvina
Published: May 2024

Periodontal diseases are chronic diseases that affect the surrounding tissues of the teeth and the alveolar bone. As the disease progresses, it can lead to tooth loss. Several risk factors may increase the risk of periodontal disease. The objective of the study was to assess the independent variables of periodontal disease among the few of the Southern population of India. The current study was done on 155 patients who visited Saveetha Dental College and Hospitals. Data of demographic details (age, gender, educational status) and periodontal status (clinically healthy gingiva, gingivitis, and periodontitis) were recorded. The demographic and the periodontal parameters were associated using Chi-square test (SPSS Software, Version 23.0). 20–30-year-old patients were mostly affected with gingivitis (25.8%) and 51–60-year-old patients were affected with periodontitis (22.58%). This showed statistical significance (P < 0.05). More males were affected with periodontal diseases than females and were statistically insignificant (P > 0.05). Periodontitis was more common among illiterates (26.45%) and was statistically significant (P < 0.05). The study shows that periodontitis was predominantly seen among males of 51–60 years of age and illiterates. The results of the study reveal a positive association between age, gender, and educational status of patients with their periodontal health.
Berry as an adjunct to nonsurgical periodontal therapy
Authors: Sharma M. Neha , Rajasekar Arvina
Published: May 2024

Periodontal disease, a persistent inflammatory condition affecting the tissues around the teeth, is brought on by an imbalance between dental biofilm and the host's reaction, with the potential for tooth loss. Periodontal disease has been linked to an excess of free radicals induced by oxidative stress or antioxidant deficiency. There is a notable oxidative process early in the course of periodontal disease, especially in periodontitis. The objective of the study is to assess if berry supplements can be used as a supplement to nonsurgical periodontal therapy. Forty individuals with chronic periodontitis in total were divided into two groups for this study. Group A received scaling and root planing (SRP), whereas Group B received SRP plus berry supplements. At baseline and on the 28th day, both groups had their probing pocket depth (PPD) and clinical attachment level (CAL) assessed. After then, the data from both time periods were compared. The SPSS software was used to examine the data (Version 23.0). Using an unpaired t-test, the mean PPD and CAL values were compared between the groups. The mean PPD in Group A decreased on day 28 from 4.18 ± 0.12 to 3.06 ± 0.02 while in Group B reduced from 4.21 ± 0.13 to 2.05 ± 0.08. The CAL in Group A improved from 5.05 ± 0.09 to 3.04 ± 0.11 and in Group B from 4.52 ± 0.17 to 2.02 ± 0.08. There was evidence of a statistically significant difference between two groups in terms of mean pocket depth and clinical attachment degree (P < 0.05). Therefore, berries may be an effective treatment for chronic periodontitis when used in conjunction with SRP.
Evaluation of mandibular condylar morphology using orthopantomogram in South Indian population
Authors: Varshan Ilammaran , Prathap Lavanya
Published: May 2024

The most complex and important portion of the body and masticatory system are the temporomandibular joint. The growth of mandibular bone in both sagittal and vertical directions is by the condylar process. This study is done to determine different shapes of mandibular condyles using orthopantomographs (OPGs). The study's goal was to determine the morphology of the mandibular condyle in South Indians. One hundred digital OPGs with no defects were selected and obtained from private dental institutes and hospitals in Chennai for this study. The morphology of the mandibular condyle was studied and tabulated. Using the SPSS software, the Chi-square test was done to find associations between demographics and morphology. The study was an attempt to find the prevalent shape of the condylar head using a panoramic radiograph. Fifty-one percent were oval in shape, 20.5% were bird beak in shape, 13.6% were diamond in shape, and 14.9% were crooked finger in shape. The results suggest an oval–oval shape in more frequency among both genders. OPGs are the most commonly used and interpreted radiographs, due to their low radiation and easy availability among dentists. Hence, the shape of the mandibular condyle can also be determined using OPGs; future studies are to be conducted in large samples to make the context evident.
Herbal-mediated preparation of nano-sized particles of selenium, its characterization, and evaluation of its antimicrobial activity
Authors: Katyal Deepika , Jain Ravindra Kumar , Sreenivasagan Swapna
Published: May 2024

This study aimed to synthesize selenium nanoparticles (SeNPs) using stevia plant leaves and to evaluate the antimicrobial effect of nano-sized particles of selenium. A new organic synthesis of nano-sized selenium particles was done in this study. In this study, stevia leaves for the synthesis of nano-sized particles along with sodium selenite were done. This mixture was mixed homogeneously using an orbital shaker overnight. The color change indicated the formation of SeNPs. The SeNPs were evaluated for their size and shape and their antimicrobial property was assessed. SeNPs showed excellent antimicrobial activity against Candida albicans at 100 μL concentration. At 25 μL and 50 μL, C. albicans showed intermediate susceptibility to SeNPs which also indicated a good antimicrobial potential. Following C. albicans, SeNPs showed good antimicrobial potential against Streptococcus mutans at all concentrations. SeNPs possessed good antimicrobial activity against most common oral pathogens.
Prevalence of class I caries in the second maxillary primary molar in 3–6-year-old children
Authors: Harini B. , Gurunathan Deepa , Padmapriya S.
Published: May 2024

Class I caries is located in the occlusal surface of molars and premolars. Dental care is an international public health challenge, mainly in young group children, as they are easily affected by caries with an increased addiction to sweets and chocolates. Caries begin early in life and progress rapidly and can affect a child in the long-term quality of life. The data were collected from the institutional patient records between June 2015 and February 2021. The details of 6831 pediatric patients were collected, of which 1500 patients fulfilled the inclusion criteria. The data were collected and analyzed using SPSS software (IBM Corp, IBM SPSS Statistics for Windows, Version 24.0. Armonk, NY). P = 0.005 was set as level of significance. Highest prevalence of caries was seen in male children with P = 0.008 (<0.05), denoting that there is a significant association between gender and number of teeth affected with caries. When age group was considered, the caries prevalence was highest at the age of 4 years and the P value was statistically significant. The prevalence of class I caries in the second maxillary primary right molars was more than the second maxillary primary left molars and within the age group of 4 years.
Characterization and antimicrobial activity of cerium oxide nanoparticles synthesized using neem and ginger
Authors: Devi N Sanjana , Ganapathy Dhanraj M. , Rajeshkumar S , Maiti Subhabrata
Published: May 2024

The aim of this study is to analyze and characterize the antimicrobial effect of cerium oxide nanoparticles (NP) synthesized using neem and ginger. Finely grounded neem and ginger powder were taken and mixed with distilled water. This mixture was then heated and filtered. Ammonium cerium nitrate dissolved in distilled water. Both the mixtures were mixed and stirred magnetically. A double-beam ultraviolet-visible spectrophotometer was used to monitor color changes. The extract was centrifuged at 8000 rpm for 15 min. The final pellet was powdered using a hot air oven at 70°C for 24 h. Visualization was done by transmission electron microscopy and spherical morphology was noted, with an average diameter of 5 nm, in aggregated form. The sample containing 100 mg of cerium oxide shows the most significant effect on the zone of inhibition of 11 mm of Staphylococcus aureus. The results obtained in the current study confirmed that CeO-NP possessed antioxidant and cytotoxic properties.
Efficacy and safety of potential vaccine candidates against coronavirus disease 2019
Authors: Kumar Subodh , Saurabh Manoj Kumar , Maharshi Vikas
Published: May 2024

Search for an effective and safe vaccine to prevent transmission of current pandemic is an unmet need. This study reviews and compares the available early phase clinical data of vaccine candidates which have reached phase 3 of clinical development. The latest update of “DRAFT landscape of coronavirus (CoV) disease 2019 candidate vaccines (October 2, 2020)” released by the World Health Organization was accessed to identify the potential vaccine candidates. The full text articles (published and/or preprint) of data of early clinical trials of the selected vaccines were accessed from the links provided in the same document, PubMed and/or medRxiv.com. After extraction and synthesis, the data were critically evaluated for the study efficacy and safety outcomes. Of the total 193 candidate vaccines 10 were found to reach phase 3 of the clinical development. Nine of these were included in the evaluation process. In all of the included studies, immunogenicity and serious adverse events/local or systemic adverse events/laboratory parameters abnormality was considered as efficacy and safety outcomes respectively. Immunogenicity response with most of the vaccines was either higher than or similar to the respective controls except one (recombinant adenovirus type 26 COV2 [Ad26.COV2.S]) for which it was less than that in control. Overall adverse events (related and/or unrelated) were more with vaccines than those with respective control(s) in three studies, in other two, these were similar whereas in one study, the events were less in the vaccine group than in control group and in the rest, data described were descriptive only without any mention for the same for the control. In conclusion all studies showed immunogenic response to target protein of severe acute respiratory syndrome CoV-2 and which was higher than the respective control except for Ad26.CoV2.S. Many of the vaccines caused more adverse events than the controls, however most were mild and transient and/or manageable.
Antioxidant properties of the methanolic extract of avocado fruit peel (Persea americana Mill.) from Indonesia
Authors: Rahman Nurdin , Sabang Sri Mulyani , Abdullah Rukman , Bohari Bohari
Published: May 2024

This study analyzed the antioxidant activity and the phytochemical substances in avocado fruit peel extracted with methanol. In this study, antioxidant activity was determined by IC50 based on the regression value of DPPH free radicals’ inhibition. Phytochemical content was measured qualitatively concerning the total content of phenols, flavonoids, tannins, saponins, and alkaloids. Our measurements showed that the methanolic extract of avocado fruit peels from Indonesia had the value of each phytochemical compound as follows: total phenol was 21.833 ± 0.118 mg/100 g extract; total flavonoids were 2.607 ± 0.111 mg/100 g extract; total tannin was 38.357 ± 0.202; saponin content was 8.874% ± 0.031%; and total alkaloid was 9.95 ± 0.035 mg CE/g extract. They then provided the antioxidant activity in IC50, which reached 185.891 ± 1.598 ppm. Avocado fruit peels are identified as a phytochemical source that contributes to antioxidant activities.
Standardization of Leonurus sibiricus L. aerial part and capillary electrophoresis quantitative analysis of its leonurine content
Authors: Suwatronnakorn Maneewan , Issaravanich Somchai , Palanuvej Chanida , Ruangrungsi Nijsiri
Published: May 2024

The quality parameters of Leonurus sibiricus L. aerial part crude drugs were evaluated. Fifteen crude drugs were collected from various locations throughout Thailand. The transverse section of the stem of L. sibiricus showed quadrangular character highlighted the ribs with angular collenchyma. The epidermis was uniseriate with abundant glandular trichomes distribution. Prismatic calcium oxalate prisms were found in the stem medullary parenchyma.The histological character of crude drug powder showed bordered pitted vessel, fragment of fiber, glandular trichome, prism crystal, spiral vessel, starch granule, and stomata. The loss on drying, total ash, acid-insoluble ash, and moisture contents should be not more than 8.18, 15.28, 4.04, and 8.91 g/100 g dry weight, whereas ethanol and water-soluble extractive values should be not less than 7.67, and 17.21 g/100 g of dry weight, respectively. Leonurine in the crude drugs were analyzed by capillary electrophoresis (CE) with photodiode array detector. The ethanolic extraction performed by Soxhlet apparatus yielded 18.86 ± 4.09 g/100 g dry weight. The electropherogram detected at 277 nm showed the migration time of leonurine at 6.2 min. The developed CE was found to be valid for leonurine quantification in L. sibiricus ethanolic extract. The contents of leonurine in 15 crude drugs ranged from 0.79 to 4.23 mg/g with the average of 2.38 ± 1.10 mg/g dry weight. This study established the pharmacognostic specification of L. sibiricus crude drug in Thailand with special reference to a bioactive compound, leonurine. CE was beneficial technique for the analysis of leonurine in L. sibiricus aerial parts.
Validation of warfarin enantiomer analysis method in plasma using high-performance liquid chromatography fluorescence detector
Authors: Putriana Norisca Aliza , Rusdiana Taofik , Rostinawati Tina , Akbar Mohammad Rizki , Saputri Febrina Amelia , Utami Siti
Published: May 2024

Warfarin (WF) is an anticoagulant commonly used for thromboembolism-related diseases. This study aims to assess the pharmacokinetic profile of WF. The stereospecific interaction of S-and R-WF requires quantification of the enantiomer to determine the pharmacokinetic profile. The analysis method of the enantiomers in plasma is developed using an HPLC fluorescence detector with a Chiralcel OD-RH column (4.6 mm × 150 mm i.d., 5 m) and a Chiralcel OD-RH guard column (4.0 mm × 10 mm, 5 m). The separation is conducted using isocratic with acetonitrile mobile phase: Phosphate buffer, pH 2.00 (40:60 v/v), column temperature 40°C, flow rate 1 mL/min, injection volume 50 L. WF is measured at an excitation wavelength of 310 nm and emission of 350 nm. This method results in limit of detection (LOD) values of 18.6 ng/mL and limit of quantitation (LOQ) of 62.01 ng/mL for R-WF and LOD values of 18.61 ng/mL and LOQ of 62.04 ng/mL for S-WF. The results showed a linearity in concentration between 100 and 2500 ng/mL with r
2 = 0.9969 and r
2 = 0.9991 for R-and S-WF. The validation requirements of selectivity, accuracy, and precision for within and between run with a value of <15% for % relative standard deviation and % diff were achieved. This method can be used in the sample measurement of WF pharmacokinetic studies.
Estimation of wettability of topical fluoride gel on anterior and posterior teeth
Authors: Srinivas Kiran , Ganesh S. Balaji , Jayalakshmi S.
Published: May 2024

The surface area determination has a vital role in measuring the properties of liquid and solid substances. Fluoride is a potent remineralizing agent of the teeth. The surface area is measured using a goniometer. The main aim of this study is to estimate the wettability of topical fluoride gel on the anterior and posterior teeth surfaces. Topical acidulated phosphate fluoride (APF) gel was taken in small quantities. Anterior and posterior teeth were collected, and their superficial unaltered enamel sections were used as the surface where the contact angle (CA) is determined. The surface wettability is determined using Ossila goniometer to measure CA. Each stage was mounted on a mechanical stage of the goniometer. A calibrated microsyringe was used to dispense drops of the APF gel over the surface of the specimen Group A (anterior tooth cut section) and Group B (posterior tooth cut section). This procedure is repeated for all specimen samples. The mean of CAs of the anterior teeth (88.41°) was greater when compared with the mean of posterior teeth (80.36°) CA. P value found using the paired t-test of SPSS software is found to be 0.271 (>0.05), hence statistically not significant. The greater the CA, the lower is the degree of wettability on the teeth surfaces. The mean CA of the topical fluoride APF gel on the anterior tooth surface is greater when compared to the posterior tooth surface. This signifies that greater wettability is seen on posterior tooth surfaces.
Effect of disinfectants on the tear strength of addition silicone impression material – An in vitro study
Authors: Guntupalli Yoshita , Ganesh S. Balaji , Jayalakshmi S.
Published: May 2024

Addition silicone is a newer type of silicone impression material which has high dimensional stability, accuracy, and flexibility. They are mostly used for fixed restorations such as crowns and bridges. They have high tear strength; however, this strength may be altered upon disinfection. Disinfection of addition silicone prior use is important to reduce the microbial load. The aim of this study is to check whether there is any change in tear strength of addition silicone on disinfection with two commercially available disinfectants. Zhermack Elite HD + Putty material was tested in this study. Base and catalyst material was mixed and the material was cut into strips of dimension 70 mm × 10 mm × 2 mm. Five strips were immersed in sterillium and five strips were immersed in glutaraldehyde solution. These strips were then tested for their tear strength using Instron E3000 Universal Testing Machine. The values obtained were recorded in SPSS software version 22 (IBM SPSS Statistics for Windows, Version 23.0. Armonk, NY: IBM Corp.) for analysis and the P was obtained. The mean tear strength of Group 1, addition silicone immersed in sterillium disinfecting solution was found to be 7.148 ± 2.654 kN/m. The mean tear strength of Group 2, addition silicone immersed in glutaraldehyde disinfectant solution was found to be 7.326 ± 4.062 kN/m. An unpaired Student's t-test was done and P was found to be 0.235. The tear strength values between the groups was statistically not significant. Hence the tear strength of addition silicone was found to be greater in the glutaraldehyde disinfectant solution group.
Comparative analysis of effect of fruit juices on surface roughness of bulk fill and flowable composite material
Authors: Kallivayalil Joseph George , Ganesh S. Balaji , Jayalakshmi S.
Published: May 2024

Resin-based composites have been widely used to reconstruct anterior and posterior teeth, as dentistry has progressed and there has been an increasing interest in the creation of suitable materials to replace damaged tooth tissue. The aim of the study is to compare the effect of fruit juices on the surface roughness of bulk fill and flowable composite restorative material. A total of 8 bulk fill composite and flowable composite resin disc samples were made. These eight samples were tested for surface roughness following immersion in three juices which were pineapple juice, lime juice, orange juice, and distilled water as the control group. They were immersed at room temperature for 7 days. Surface roughness was evaluated by the Mitutoyo SJ-310 contact profilometer. It showed that there was a decrease in the Ra value of flowable composite when compared to bulk fill composite. Rq and Rz values were more for the flowable composite resin group. Flowable composite resin samples had more surface roughness than bulk fill dental composite restorative material after exposure to pineapple, lime, and orange juices.
Learning and satisfaction levels with online teaching methods among undergraduate dental students – A survey
Authors: Pratheebha C. , Jayaraman Mahalakshmi
Published: May 2024

Taking an online course requires more motivation and self-discipline than taking a classroom-based course. One or more teachers and peers may keep a student responsible for their course work in a classroom. Online classes, on the other hand, enable us to set our own targets, chart our success, and follow deadlines. An awareness-based, self-administered questionnaire was created. The target audience for the study received a link to the questionnaire through Google Docs. The participants were given a thorough explanation of the survey's objectives. Pie charts with a frequency table were created after the survey findings were known. A Chi-square test was used to examine for associations in the statistics, and a P = 0.05 was considered statistically significant. The overall satisfaction level with online classes among students was, 57% were not satisfied with online classes, 31% were satisfied, and 12% were extremely satisfied. Most commonly students were not satisfied with both genders. However, majority of the females were not satisfied. This difference was statistically significant (Pearson's Chi-square value: 1.999, df = 2, P = 0.368 (>0.05) – significant). Eighty percent of the students have faced difficulties while attending online classes. However, 92% of the students have agreed that the technology helped them to attend their online classes.
The interaction of alpha-mangostin and its derivatives against main protease enzyme in COVID-19 using in silico methods
Authors: Hidayat Syahrul , Ibrahim Faisal Maulana , Pratama Kelvin Fernando , Muchtaridi Muchtaridi
Published: May 2024

More than 111 million people worldwide have been affected by the COVID-19 outbreak caused by SARS-CoV-2. The main therapeutic target of COVID-19 is main protease (Mpro). It plays a key role as an enzyme in the SARS-CoV-2 replication and transcription. In this case, the alpha-mangostin potentially has antiviral activity against Mpro by inhibiting this enzyme. Nevertheless, the alpha-mangostin has low solubility and a lack of information about alpha-mangostin activity against the SARS-CoV-2. The aim of this study is to describe the molecular interactions and identify the pharmacokinetics profile between alpha-mangostin and its derivatives. in silico study was conducted by pharmacokinetics and toxicity prediction, molecular docking simulation, and Lipinski's rule of five. FKS9 has a Gibbs free energy value of-10.5 kcal/mol with an inhibition constant of 36.45 μM and an interaction with amino acid His41 residue. Its human intestinal absorption and Caco-2 values were 95.13% and 47.71% while the plasma protein binding and blood-brain barrier values were 96.66% and 6.99%. FKS9 also has no mutagenic and carcinogenic potential. FKS9 as an alpha-mangostin derivative had the best interaction with the Mpro enzyme and its pharmacokinetic profiles was identified.
Evaluation of accuracy and time taken to make an open tray implant impressions with two techniques
Authors: Teja Reddy M. Sai , Ahmed Nabeel , Maiti Subhabrata , Ganapathy Dhanraj M.
Published: May 2024

Implant dentistry's emergence and acceptance have provided physicians with a wide range of new options for fixed and removable rehabilitation. The eventual replacement of the lost tooth is the ultimate success, and this can be accomplished using recognized prosthodontic methods. The present study aims to evaluate the time and dimensional accuracy of implant definitive models with an open tray impression with two different techniques. Impression was made in two different techniques and the cast was poured and checked for the time taken and the accuracy of the impression. In IBM SPSS software version 23.0 all the results were statistically analyzed. An Independent t-test was performed for the parameters. No statistically significant difference was present (P > 0.05) when comparing the accuracy and time taken between the two groups. It is concluded that time taken and the misfit is less for modified open tray impression techniques when compared to the regular open tray impression.
Presence of impacted supernumerary teeth in the Indian population
Authors: Timothy Chris Noel , Ganapathy Dhanraj , Pandurangan Kiran Kumar , Ahmed Nabeel , Maiti Subhabrata
Published: May 2024

A tooth that does not erupt into the dental arch during the anticipated developmental window is said to be impacted. A supernumerary tooth (ST) would be any dentition or odontogenic entity that grows from a tooth germ more often than is typical for a particular area of the dental arch (ST). The study's goal is to determine how commonly impacted supernumerary teeth are present within the Indian community. This research project at the institution which was retrospective was done on dental patients who went to the private dental hospital between March 2020 and March 2021. We looked over the medical records of 86,000 patients at the private dental institution and analyzed the data. In the study's 74,421 impaction cases, 139 instances of impacted extra teeth were found. For statistical analysis, collected data were analyzed, entered into an Excel document, and imported into SPSS version 21. In the study population, males between the ages of 21 and 35 years were more frequently observed to have supernumerary impacted teeth. Impacted teeth were more frequently observed in the posterior region rather than the anterior region. Within the constraints of the study, it was shown that males between the ages of 21 and 35 years and the posterior part of the mouth experienced impacted supernumerary teeth the most frequently.
Professionalism practiced by dental students – Patient's perspective
Authors: Agarwal Sanjog , Maiti Subhabrata , Agarwal Vatika
Published: May 2024

The aim of this study is to evaluate a patient's perspective regarding professionalism practiced by dental students in a university hospital setup by survey questionnaire. A questionnaire was formulated and was distributed among patients who visited for their treatment to the outpatient department of the hospital in a university setting. The study group consisted of adult individuals who attended the outpatient Department of Prosthodontics from June 2020 to April 2021. Three hundred questionnaire forms were distributed and 152 were received back; Chi-square test and frequency analysis were the statistical tests used to explore the relationship between two variables. Institutional clearance was taken from the institute (certificate No.IHEC/SDC/PROSTHO/21/043). There is more prevalence of males 52.6% compared to females 47.4%. Age group 31–40 years comprises the maximum number of patients. 52.6% of patients had their monthly income between 10,000 and 30,000 rupees. 84.2% of patients answered name badge to be desirable, 57.9% told surgical scrubs to be desirable, and 47.4% of patients answered cologne to be desirable. 68.4% of patients were neutral to clogs, 84.2% of patients were neutral toward shoes. All the patients agreed that the behavior and communication skills showed a good competence level of the students. Overall, there was a difference but there was no significance among different variables. The patient considers the dentist's altruistic behavior and communication skills to be more crucial; these two factors are regarded as the foundation for a strong patient–dentist professional relationship. For effective patient-centered service, both the dentist and the patient must agree on these ideals. Medical/dental educators must make significant efforts to reflect the dynamic nature of professions in dental education.
Expectation of treatment outcomes in complete denture wearers
Authors: Devi B. Vaishnavi , Ahmed Nabeel , Ganapathy Dhanraj , Maiti Subhabrata , Pandurangan Kiran Kumar
Published: May 2024

Edentulism is a condition associated with age, and the outcome of prosthodontic treatment depends on a number of dental and nondental factors. In complete denture therapy, patient satisfaction is a key objective and various other variables affect this parameter. The ability to foresee its preferences may assist dentists in making informed treatment selections. The study purpose is to assess the expectations of treatment outcomes in complete denture users. For the study, all cases referred for total denture therapy during September 2020 and February 2021 were included. Both new and old denture users completed questionnaires on factors such as retention, mastication, phonetics, esthetics, and comfort. Excel was used to compile the data, which was then imported into SPSS for statistical analysis. The study's statistical significance level was established at P < 0.05. Male patients over the age of 60 years wearing dentures were very common. Denture wearers were highly prevalent in the age group of >60 years among male patients. Retention, esthetics, and phonetics are highly satisfied in existing denture wearers and mastication is highly satisfied in new denture wearers. The comfort factor is commonly satisfied in both the denture wearers. The results were statistically significant with a P = 0.05. Clinician can plan their treatments more effectively if they are aware of the treatment's expectations.
Knowledge, awareness, and prevalence of various types of suturing techniques used for intraoral wound closure
Authors: Umakanth Kethan , Neralla Mahathi , Prabu Dinesh
Published: May 2024

Wound closing is critical to the completion of any surgical operation. An imperfect closure causes edge isolation, creating a possible route for bacterial contamination, which can lead to infection and scarring. While tissue adhesives and staples are now used as substitutes, surgical sutures remain the gold standard for a safe wound. The aim of this survey is to assess dental students' knowledge on the variety of suturing techniques. A comprehensive online survey of 100 dental students with simple questions about different types of sutures was performed. Each student was asked to complete a questionnaire of 20 questions. This study saw a total of 100 students take part in it. It was found that 58% of the participants opted for interrupted suturing technique and the rest 42% opted for simple continuous technique. It was found that 23% of the participants were not aware of the simple loop suturing technique and the rest 77% were aware of this suturing technique. Thus from the above results and discussion, we will conclude that almost all of the members are fairly privy to the distinctive suturing strategies; however; intensive expertise is required.
Dipeptidyl peptidase IV inhibition of phytocompounds from Artocarpus champeden (Lour.) Stokes
Authors: Supandi Supandi , Wulandari Mesy Savira , Samsul Erwin , Azminah Azminah , Purwoko Reza Yuridian , Herman Herman , Kuncoro Hadi , Ibrahim Arsyik , Silfi Ambarwati Neneng Siti , Rosmalena Rosmalena , Azizah Rizqi Nur , Paramita Swandari , Ahmad Islamudin
Published: May 2024

The present study examines the potential activity prediction based on free binding energy (ΔG) and interaction confirmation of phytocompounds from Artocarpus champeden (Lour.) Stokes with macromolecule protein receptor of dipeptidyl peptidase IV (DPP-IV) using in silico molecular docking studies and physicochemical and pharmacokinetic properties (ADME-Tox) prediction approaches. The active subsites of the DPP-IV receptor macromolecule protein Protein Data Bank (ID: 1 × 70) were docked using Autodock v4.2.6 (100 docking runs). A grid box of 52 × 28 × 26 Å points spaced by 0.37 Å was centered on the active site of x = 40.926 Å; y = 50.522 Å; z = 35.031 Å. For ADME-Tox prediction, Swiss ADME online-based application programs were used. The results show that 12 pythocompounds from A. champeden have the potential as DPP-IV inhibitors based on ΔG value and interaction conformation. There are five pythocompounds with lower ΔG values and inhibition constants than the native ligand and seven pythocompounds with ΔG values and inhibition constants close to the native ligand. The 12 compounds form an interaction conformation at the active subsites of the DPP-IV receptor. At the same time, the results of the ADME-Tox prediction analysis showed that the 12 compounds had different physicochemical and pharmacokinetic properties.
Average time in between appointments for multivisit pulpectomy in patients reported to a university dental hospital
Authors: Srinisha M. , Ramakrishnan Mahesh
Published: May 2024

Complete removal of the infected coronal and radicular pulp tissue along with obturation of the canal space with suitable medication is defined as pulpectomy. The most common indication for pulpectomy is a tooth with irreversible pulpitis which shows symptoms of nocturnal pain and abscess. To determine the average time in appointments for multivisit pulpectomy in patients reported to a university dental hospital. It is planned as a retrospective analysis of the case records of patients who were treated as two visit pulpectomy procedures in a university dental hospital, India. The study concluded that in the majority of the situations the average time in between appointments for multivisit pulpectomy was found to be within 1 week.
Awareness and knowledge of oral manifestations in cardiovascular diseases among the general public
Authors: Shreenidhi S. , Veeraraghavan Vishnu Priya , Gayathri R. , Selvaraj Jayaraman , Kavitha S.
Published: May 2024

Cardiovascular diseases (CVDs) are disorders affecting the heart and blood vessels. Periodontal problems, bleeding gums, dry mouth, and gingival hyperplasia are common oral manifestations seen in cardiovascular-related problems. To assess the extent of awareness and knowledge, the general public has toward the oral manifestation related to that of CVDs. A questionnaire was distributed among the general public in relation to that of the extent of awareness and knowledge of oral manifestations with regard to CVD. A total of 161 responses were collected from the survey. The collected data were compiled and analyzed by the SPSS software; the Pearson Chi-square test was done where P < 0.05 was considered statistically significant. The study showed that 65.22% of the population is aware of the types of CVD. About 59.63% of the population do not know that periodontal problems lead to cardiovascular problems. About 39.75% have vague knowledge about the maintenance of poor oral health causing cardiovascular problems. The study concluded that the general public is not much aware of the oral manifestations related to that of CVDs.
Evaluation of adverse drug reaction in patients warfarin therapy
Authors: Putriana Norisca Aliza , Rusdiana Taofik , Rostinawati Tina , Akbar Mohammad Rizki , Destiani Dika Pramita
Published: May 2024

This research aimed to understand the adverse drug reaction (ADR) in heart disease outpatients who were administered warfarin at a hospital in Bandung city. The research was conducted using a cross-sectional design with an observational approach. Subsequently, data were collected from 74 patients who met the inclusion criteria. The causality assessment was made by the Naranjo Algorithm and the incidence of bleeding was classified based on the Bleedscore™. The result showed that the most common ADR were nausea, dizziness, stomach ache, ecchymosis, petechiae, bleeding in the mouth, melena, etc. Furthermore, the INR value was the most significant factor in the incidence of ADR. It was 6.445 using a value of P = 0.001 or a confidence interval of 95%. The most common side effect of warfarin in cardiac outpatients was superficial bleeding, followed by internal bleeding (melena). The INR value is the most significant factor in measuring the incidence of ADR.
Phytochemical screening, quantitative analysis of cyanidin-3-O-glucoside content, and anticancer activity of novel rice bran (Tubtim Chumphae rice)
Authors: Rungruang Rittipun , Peasura Napassorn , Kaisangsri Nattapon
Published: May 2024

The objective of this research was to explore the phytochemicals in Tubtim Chumphae rice bran and determine their potential antioxidant and anticancer activities. The rice bran extract contained total phenolics, flavonoids, and anthocyanins as the major compounds. In addition, it exhibited the highest DPPH•, followed by ABTS•+, and FRAP radical scavenging activity. Moreover, the cytotoxic effect of the extract on Hep G2, SW620, KATO-III, BT474, and ChaGo-K-1 cancer cell lines was investigated; the obtained IC50 values were 144.6 ± 0.39, 116.9 ± 0.68, 99.6 ± 0.10, 94.4 ± 0.33, and 25.6 ± 0.45 μg/mL, respectively. Overall, the abovementioned results suggest that rice bran extract has potent anticancer activity owing to the induction of cell death in cancer cell lines.
Preparation and evaluation of oral soft chewable jelly containing flurbiprofen
Authors: Sabri Lubna Abdalkarim , Khasraghi Abeer H , Sulaiman Hala Talal
Published: May 2024

Oral jelly is a semisolid preparation that could resolve problem associated with dosage form's swallowing, especially in pediatric and elderly ones. This work aimed to prepare oral flurbiprofen (FBP) jelly to improve patient compliance. Heating and congealing method was used to prepare FBP jelly using three different polymers (pectin, sodium carboxymethyl cellulose, and hydroxypropyl methylcellulose). The effect of different concentrations of pectin and sucrose on jelly properties was studied. The results revealed that both pectin and sodium carboxymethyl cellulose polymers gave acceptable jelly appearance and consistency. It was also observed that the increase of pectin or sucrose concentration had a significant impact on jelly viscosity. All pectin jellies except formula containing 5.5% pectin and 50% weight by volume (w/v) sucrose exhibited more than 50% and 85% of FBP releasing within 15 and 30 min, respectively. The formula (FP2) consisting of 4.5% pectin and 40% w/v sucrose was selected as optimum formula which had a high percent dissolution efficiency (78.95%) and better consistency during handling. This work succeeded in the preparation of new FBP oral jelly, which can be considered a promising dosage form for enhancement of patient compliance and drug solubility.