bluuebunny/crossref_metadata_2025 huggingface dataset:
THE APPLICATION OF SEFL DECLARE SYSTEM ON HALAL GUARANTEE SYSTEM ON MICRO AND MEDIUM ENTERPRISE
Authors: Putranto Adik Dwi
Published: December 2024

Since the introduction of micro and medium enterprise and its legal acknowledgement in Indonesia, the development of these enterprises is growing steadily fast. Upcoming micro and medium enterprise in Indonesia has grown large and spread evenly throughout Indonesian archipelago. Seeing the growth, Indonesian government tried to accommodate the growth by introducing regulation to regulate and help them grow. One of the favor given by the government is the ease of Halal Certificate for these micro and medium enterprise. Usually, the Halal Certificate will be given by assessing the business. For micro and medium enterprises, they are given the choice to ‘self-declare’ their product as Halal without going through the usual process. However, in the implementation of this system, the standardization of Halal for ‘self-declare’ system need to be set straightly as if no proper procedure is given, there will be numerous non-halal product labelled as halal through the ‘self-declare’ system. The research has shown that through proper mechanism and by abiding the procedure given by the law, the standardization of halal throughout ‘self-declare’ system could be carried out in ease.
AFFIRMATIVE ACTION POLICY ON WOMEN'S REPRESENTATION IN THE HOUSE OF REPRESENTATIVES
Authors: Talaba Renals
Published: December 2024

Affirmative policies and the low representation of women in the House of Representatives (DPR) indicate obstacles within the design of the electoral and party systems. Therefore, this study aims to identify the challenges posed by the operation of technical variables in both indirect and direct electoral systems regarding women's representation in the DPR. To achieve this goal, the study employs the Rational Choice Neoinstitutionalism (RCN) approach. This approach seeks to understand how systems, structures, and institutions are designed and interact to achieve specific objectives. The purpose of political institutionalization is to make political institutions more accountable, transparent, controlled, responsive, participatory, and rooted in the rule of law. This study adopts a literature review method, summarizing and analyzing ideas from various sources to develop an understanding and theory about affirmative policies, followed by a review of the operationalization of technical electoral variables within electoral regulations. The findings reveal that affirmative policies in Indonesia's democratic electoral system do not guarantee women's representation in the DPR. This is because affirmative policies are focused solely on electoral formulas, while other technical variables are deemed disadvantageous. This is evident from the number of women in the DPR from the 2004 to 2024 elections, where women's representation has not yet reached the critical mass threshold
Moderating effect of work experience on motivation and performance at Islamic hospital
Authors: Purnama Chamdan , Rahmah Mirhamida , Fatmah Dinda , Putri Karina Ananda , Hasani Syaiful , Rahmah Yusriyah , Rahmah Zakiyah Zulfa
Published: December 2024

Purpose – This study examined the moderating effect of work experience on the relationship between work motivation and employee performance at an Islamic hospital in East Java. It explores how varying levels of experience influence the impact of motivation on performance, providing insights into improving workforce effectiveness.Methodology – An explanatory design was used with a sample of 150 Islamic hospital employees selected using proportional sampling. Data were collected through structured questionnaires using a five-point Likert scale. Multiple and interaction regression analyses were performed using IBM SPSS Statistics version 25 to assess the relationships between work motivation, work experience, and employee performance as well as the moderating role of experience.Findings – The results show a significant positive relationship between work motivation and employee performance, with motivated employees consistently achieving higher performance levels. Work experience significantly moderated this relationship, amplifying the positive effect of motivation on performance. Employees with more experience experienced greater performance improvements when motivated, highlighting the critical role of experience.Implications – These findings provide practical insights for hospital management, suggesting that motivational strategies should consider different levels of experience. Customized training programs, experience-based development, and rewards aligned with work experience can enhance motivation and performance, and improve retention and organizational outcomes.Originality – This study contributes to the existing literature by providing empirical evidence of the moderating effect of work experience on the motivation-performance relationship in the healthcare sector, offering practical recommendations for experience-based employee management development strategies. Motivation strategies to optimize employee performance and enhance organizational outcomes.
Boycotts and brand perception of mineral water affecting generation Z Muslim purchases
Authors: Khasanah Miftakhul , Kaha M. Radjasa Sing Agul Kusuma
Published: December 2024

Purpose – This study aims to identify the determinants of purchasing decisions for bottled mineral water among generation Z Muslims in Indonesia, particularly in light of product boycotts. Methodology – The sample consisted of 189 respondents, with the criteria being generation Z Muslims in Indonesia who have made purchases of mineral water after the boycott actions against several mineral water brands in Indonesia due to the conflict between Israel and Palestine. Findings – Purchasing decisions for mineral water by generation Z Muslims in Indonesia are influenced by halal labeling, brand perception, and promotions related to social and ethical issues, including boycotts against certain brands. The analysis results indicate that consumers not only consider the quality and halal aspects of the product, but also actively respond to the values promoted by the brand, especially in relation to controversies involving brand affiliations with entities that do not align with Islamic principles. Implications – The mineral water industry needs to manage brand image and marketing strategies by considering the cultural and social values of consumers, particularly generation Z Muslims in Indonesia. With the growing awareness of ethical and political issues, the industry must ensure that its products meet quality and halal standards, as well as avoid associations with controversies that could trigger boycotts.Originality – This study integrates social and ethical aspects, such as responses to boycott actions and halal awareness, into consumer behavior analysis, providing a new perspective on understanding market dynamics influenced by cultural values and religious beliefs.
Применение методов Чебышева для решения эллиптических уравнений на воксельных сетках
Authors: Kritskiy Boris Viktorovich
Published: December 2024

Рассмотрены различные типы итерационных методов Чебышева для решения сеточных аппроксимаций эллиптических уравнений на воксельных сетках. Дано общее описание методов Чебышева. Приведены структура ошибки методов и способ ее устранения. В рамках работы проведено сравнение эффективности применения методов для решения систем линейных уравнений, полученных дискретизацией уравнения Лапласа с постоянными и непостоянными коэффициентами на воксельных сетках. Предложен ряд модификаций метода Чебышева. В их числе предложен вариант метода Чебышева для решения систем линейных уравнений с кластеризованным спектром. Произведено сравнение модификаций методов в случаях, когда границы спектра точно известны и в противоположном случае.
SPATIAL DISTRIBUTION PATTERNS OF POVERTY AND ECONOMIC GROWTH FOR ACHIEVING SUSTAINABLE DEVELOPMENT TARGETS IN EAST JAVA PROVINCE
Authors: Khoeriyah Siti , Juwita Aulia Hapsari , Prayoga Tedi , Fitri Siti Nurlita
Published: December 2024

Poverty and economic growth are still indicators of a country's success in managing its resources and population. Countries in the world have agreed to make poverty alleviation the first sustainable development priority. This article aims to look at the spatial distribution pattern of poverty and regional characteristics, as well as the pattern and structure of economic growth in city districts in East Java Province. The methods used include spatial autocorrelation analysis, regional financial capability analysis, Klassen typology, and regional characteristics analysis. Based on the pattern of poverty distribution for the period 2014 – 2023, poverty in East Java Province tends to change with the dominance of class 2 poverty. Sampang, Pamekasan and Sumenep regencies tend to experience a stable poverty pattern in Class 3. Pockets of poverty are clustered on Madura Island with a percentage poverty is above 18% and the characteristics of a low Human Development Index (HDI) value, low number of (people’s business credit (KUR) recipients, inadequate sanitation, not very high economic growth, and frequent flood disasters. As many as 65.78% of areas in East Java Province have high financial capacity, so that policy direction can be focused on poverty pocket areas with a high percentage of poverty, through increasing HDI, optimizing KUR, fulfilling adequate sanitation, increasing disaster response, and developing leading sectors. for increasing Original Regional Income (PAD) and economic growth.
EFFICIENCY OF HEALTH EXPENDITURE IN ORGANIZATION OF ISLAMIC COOPERATION (OIC) COUNTRIES: A DATA ENVELOPMENT ANALYSIS APPROACH
Authors: Helwa Lina Af'ida Fataya , Rima Hadijah
Published: December 2024

Studies concerning the efficiency of health spending rank among the primary priorities in global policies aimed at enhancing health equity through improved health services and care. This study focuses on countries belonging to the Organization of Islamic Cooperation (OIC) due to their limited access to healthcare, government health spending, and increasing out-of-pocket expenditure. The study aims to measure efficiency scores of healthcare expenditure in OIC member countries. This research is a quantitative study using a Data Envelopment Analysis (DEA) approach. This study using two variables this input and output variables. Input variables are such as total health expenditures, government health expenditures, and out-of-pocket health expenditures per capita PPP current International $, while output variables include life expectancy and infant mortality per 1,000 births.  All variables are secondary data derived from World Develompment Indicators (WDI) in World Bank. The research sample comprises 50 out of 57 OIC countries during 2004-2018. Results indicate that the average efficiency score of OIC countries from 2004 to 2018 was 0.551. Predominantly, countries in the Middle East demonstrated the highest efficiency scores, with Qatar leading followed by Brunei Darussalam, Kuwait, UAE, and Saudi Arabia, while Egypt recorded the lowest efficiency score. Based on this research, OIC countries are encouraged to diversify government-owned insurance policies, allocate government health expenditures more precisely, reduce the stunting rate among children, protect the health of pregnant women, and promote health investments.
Formation of motivational attitude to include tobacco and nicotine-containing products in students.
Authors:   Private institution educational organization of higher education «Medical University «Reaviz», Bolshakova P. N. ,   The Federal State Budgetary Educational Institution of Higher Education «Russian State Social University», Cherkasov S. N. ,   The Federal State Budgetary Educational Institution of Higher Education «Russian State Social University»
Published: December 2024

Monitoring of smoking as a global modifiable behavioral risk factor for chronic pathologies, tumors and premature mortality should begin in childhood and adolescence, when the first smoking attempt is made, subsequently becoming a part of the adult lifestyle.
Research objective: to study the features of the formation of motivational attitudes of medical university students to initiate the consumption of tobacco or nicotine-containing products.
Material and methods. A one-stage open uncontrolled study with random non-repeated selection of respondents in the form of an online survey was conducted to study motivational attitudes to initiate the consumption of tobacco or nicotine-containing products and to assess the degree/severity of smoking and the intensity of physical dependence on nicotine in the student environment of the medical university.
Results. 455 questionnaires were analyzed: 328 (71.9%) women and 127 men (27.9%), average age 23.55 ± 4.33 years. The most consumed products were electronic cigarettes – 44.1%, traditional cigarettes – 38.3%, electronic nicotine delivery systems 14.7%.
Regardless of the method of nicotine delivery to the body, the main factor in the initiation of smoking was the first try (16.52 ± 3.7 years), which was liked and brought pleasure in 47–100%. The second most important factor in the initiation of smoking for consumers of traditional cigarettes was the ability to cope with stress, anxiety – 51.1%. The majority of respondents (86%) did not have or had a mild degree of nicotine addiction according to the Fagerstrom test (0–2 points).
The identified features of smoking initiation require interdepartmental cooperation to develop and implement evidence-based programs aimed at developing competencies in medical students and practicing doctors to ensure smoking screening, short-term intervention and preventive counseling skills using the potential benefits of mobile health.
Improvement of organizational and medical-preventive measures aimed at preventing overweight and obesity.
Authors:   Voronezh State Medical University, Esaulenko I. E.
Published: December 2024

Relevance. Obesity is a serious public health problem due to its high prevalence, increasing treatment costs and adverse effects. In this regard, the development of preventive measures aimed at preventing the formation and progression of obesity based on modern information and digital technologies seems to be an urgent and extremely important task.
Research objective: development of a system for early diagnosis of overweight and obesity with the identification of predictors of their formation to prevent the progression of the pathological process and effective prevention of its occurrence.
Materials and methods. To assess the prevalence of overweight and obesity, an analysis of the data of the reporting forms of federal statistical observation № 30 «Information about the medical organization» and № 12 «Information on the number of diseases registered in patients living in the service area of the medical organization» for the period 2012–2023 was carried out. To assess the economic component, we used the data from reports on the summary of expenses at the expense of budget funds, funds received from the provision of paid services. The study used the following methods: analytical, statistical, comparative analysis and content analysis. Statistical
processing of materials was carried out using calculation tables in Excel format.
Results. The article presents data on the relevance and prevalence of overweight and obesity in the adult group, including the workingage population. The risks of human health impairment with possible disability and mortality due to overweight and obesity are analyzed.
Socioeconomic factors leading to obesity are considered. The economic consequences of this problem, as well as unresolved problems of obesity prevention are noted. Priority areas of comprehensive prevention programs are identified and prognostic models for the development of overweight and obesity are developed, taking into account the identified individual medical and social risk factors. The results of the study will allow personalizing preventive measures aimed at preventing obesity and its complications.
Effectiveness of preventive mammography in the Russian Federation: comparison of the results of the first stage of dispanserization in 2019 and 2022.
Authors:   State Budget-Funded Health Care Institution of the City of Moscow «Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department», Vasilev Y. A. , Son I. M. ,   Federal Research Institute for Health Organization and Informatics of the Ministry of Health of the Russian Federation,   FSBEI FPE RMACPE MOH Russia, Pestrenin L. D. ,   State Budget-Funded Health Care Institution of the City of Moscow «Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department», Vladzymyrskyy A. V. ,   State Budget-Funded Health Care Institution of the City of Moscow «Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department»
Published: December 2024

Globally, malignant neoplasms (MN) of the breast remain the most common type of cancer pathology in the female population. The main method of prevention of this pathology is screening digital mammography (MMG). In the Russian Federation, its effectiveness was evaluated in the period 2013–2019. It seems relevant to study the development of the situation in recent years, taking into account the COVID‑19 pandemic.
Purpose of the study is to examine comparatively the volume, dynamics and effectiveness of preventive mammography studies in the context of the impact of the pandemic and the rationale for the further development of medical prevention.
Materials and methods. Comparative study of the volume and effectiveness of preventive MMG. Consolidated reports based on the accounting form of medical documentation N131/u «Record card of preventive medical examination (screening) » for the period from 2019 to 2022 were analyzed. Analytical methods and descriptive statistics methods were used.
Results. In the Russian Federation, the number of preventive MMGs in 2022 increased by 4.7%, compared to 2019. Administrative-territorial units also predominantly saw an increase in the number of MMGs, except for the city of Moscow, the Central and Siberian Federal
Districts. The most significant increase was in the North Caucasian (38.0%) and Southern Federal Districts (22.2%). The pathologic incidence of breast MN according to the results of prophylactic mammography in 2022 increased significantly, by 26.4% in the Russian Federation as a whole. The exception was the city of Moscow, where a decrease in the indicator by 11.8% was noted. Various pathologic conditions during MMG are detected on average in 6.9% of cases, breast MN – in 1.0% of cases, first-time oncologic pathology is detected in 0.25% of cases.
Findings. For further development of medical prevention of breast MN it is necessary to create and implement new organizational technologies, including tools for automated analysis of the results of preventive mammography.
Digital health in medical rehabilitation after stroke: management of telemedicine technologies.
Authors:   Research Institute for Healthcare Organization and Medical Management of Moscow Healthcare Department, Nikolaev V. A. ,   Pirogov Russian National Research Medical University, Vorobtsova E. S. ,   Research Institute for Healthcare Organization and Medical Management of Moscow Healthcare Department, Nikolaev A. A. ,   University of Science and Technology «MISIS»
Published: December 2024

The development of digital technologies leads to a digital transformation of the healthcare system. Recently, digital healthcare has been developing dynamically, including its component part – telerehabilitation after a stroke. However, the novelty of technologies, their
diversity, low awareness of doctors and healthcare organizers, and other reasons, do not allow healthcare organizations to use all their tools to manage organizational, managerial and medical problems of medical rehabilitation after a stroke.
The aim of the study is to systematize information on telemedicine and cross-cutting digital technologies used in organizing medical rehabilitation of patients who have suffered a stroke, as well as the development of approaches to manage of these technologies to constantly improve the quality of healthcare and increase patient satisfaction.
Materials and methods. The study used methods of information retrieval, analytical and synthetic research, etc.
Results. The study showed that the development of technologies leads to an increase in the use of cross-cutting digital technologies in telemedicine rehabilitation of stroke patients. The results indicate the possibility of improving the quality and accessibility of medical care using telerehabilitation and cross-cutting technologies, expanding medical coverage, and improving therapeutic results in recovery of patients’ health. The PDCA cycle can be used to manage telerehabilitation and digital technologies.
Findings. The introduction of digital technologies into telemedicine practice can reduce the workload of health workers and improve manageability with respect to a patient-centric approach. The use of quality management system principles and PDCA cycle can provide the standardization of telerehabilitation management, improve the quality of healthcare and patient satisfaction, contributing to the sustainable development of healthcare organizations.
Transfemoral Osseointegration for Amputees with Well-Managed Diabetes Mellitus
Authors: Hoellwarth Jason S. , Al-Jawazneh Shakib , Oomatia Atiya , Tetsworth Kevin , Al Muderis Munjed
Published: December 2024

Background:

The most common reason for lower-extremity amputations remains the management of complications of diabetes mellitus (DM) and/or peripheral vascular disease. Traditional socket prostheses remain the rehabilitation standard, although transcutaneous osseointegration for amputees (TOFA) is proving a viable alternative. Limited studies of TOFA for vascular amputees have been published, but no study has focused on TOFA for patients with DM, neglecting this important patient population. The primary aim of the present study exploring this potential care option was to report the frequencies and types of adverse events following TOFA for patients with well-controlled DM. The secondary aims were to report their mobility and quality-of-life changes.

Methods:

A retrospective review was performed of 17 consecutive patients with well-controlled DM who had undergone unilateral transfemoral TOFA from 2013 to 2019 and had been followed for at least 2 years. Outcomes were perioperative complications, additional surgery (soft-tissue refashioning, debridement, implant removal, periprosthetic fracture treatment), mobility (daily prosthesis wear hours, K-level, Timed Up and Go Test, 6-Minute Walk Test), and patient-reported outcomes (Questionnaire for Persons with a Transfemoral Amputation, Short Form-36).

Results:

There were no perioperative systemic complications, deaths, or proximal amputations. Two patients (12%) sustained a periprosthetic fracture following a fall, managed by internal fixation with implant retention, and regained independent ambulation. Eight patients (47%) had additional surgery or surgeries for non-traumatic complications: 4 (24%) had soft-tissue refashioning, 3 (18%) had debridement, and 3 others had implant removal with subsequent revision osseointegration for aseptic loosening (1) or infection (2). The proportion of patients wearing their prosthesis at least 8 hours daily improved from 5 (36%) to 11 (79%) of 14 (p = 0.054). The proportion of patients who achieved at least K-level 2 improved from 6% to 94% (p < 0.001). Other changes were not significant.

Conclusions:

Contraindicating TOFA for all patients with DM seems draconian. Patients with well-controlled DM experienced significant mobility improvements, although additional surgery was somewhat common. Improvements in selection criteria or surgical technique to reduce risks are needed so that TOFA can be routinely considered for amputees with well-controlled DM.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Comparison of run-up models with field data
Authors: Holzenthal Elizabeth , Johnson Bradley
Published: December 2024

Run-up predictions are inherently uncertain, owing to ambiguities in phase-averaged models and inherent complexities of surf and swash-zone hydrodynamics. As a result, different approaches, ranging from simple algebraic expressions to computationally intensive phase-resolving models, have been used in attempt to capture the most relevant run-up processes. Studies quantifiably comparing these methods in terms of physical accuracy and computational speed are needed as new observation technologies and models become available. The current study tests the capability of the new swash formulation of the Coastal Modeling System (CMS) to predict 1D run-up statistics (R2%) collected during an energetic 3-week period on sandy dune-backed beach in Duck, North Carolina. The accuracy and speed of the debut CMS swash formulation is compared with one algebraic model and three other numerical models. Of the four tested numerical models, the CSHORE model computed the results fastest, and the CMS model results had the greatest accuracy. All four numerical models, including XBeach in surfbeat and nonhydrostatic modes, yielded half the error of the algebraic model tested. These findings present an encouraging advancement for phase-averaged coastal models, a critical step towards rapid prediction for near-time deterministic or long-term stochastic guidance.
Influence of Combined Transcranial and Peripheral Electromagnetic Stimulation on the Autonomous Nerve System on Delayed Onset Muscle Soreness in Young Athletes. A Randomized Clinical Trial.
Authors: Keirven Hugo , Sierra Alberto Sánchez , González-de-la-Flor Ángel , Arrabé María García , Frutos Marta de la Plaza San , Maestro Arturo Ladriñán , -Garcia-Perez-de-Sevilla Guillermo , Aguilera José Francisco Tornero , Suarez Vicente Javier Clemente , Balmaseda Diego Domínguez
Published: December 2024

Background
Delayed Onset Muscle Soreness (DOMS) has been extensively studied by scientists and sports teams over the last few decades. Eccentric exercises impact physiology and recovery, as shown in recent studies. This study investigates the effects of combined transcranial and peripheral electromagnetic stimulation on the autonomic nervous system in 48 young athletes. Participants were divided into four groups: Control (n = 12), Peripheral (n = 13), Transcranial (n = 11), and Combined (n = 12). The autonomic nervous system was assessed through Heart Rate Variability (HRV) monitoring before and after the eccentric session that induced DOMS and at 24h, 48h, and 72h post-session.
Results
The Combined Group showed increased activation in various HRV parameters, including LF (p < 0.001), HF (p < 0.001), and the LF/HF power ratio (p < 0.001). These results indicate that combined transcranial and peripheral electromagnetic stimulation enhances recovery in athletes after 72 hours.
Conclusions
Paired-associative electromagnetic stimulation positively influences the autonomic nervous system response in young athletes, promoting recovery without disrupting the typical physiological recovery process in DOMS.
Early evaluation of anti-angiogenic effects with gadolinium (III) labeled APN/CD13 specific binding peptides magnetic resonance imaging
Authors: Han Sheng , Liu Song-Song , Jing Gong-Wei , Wang Pin-Qin , Zhang Yan-Teng , Xiong Ling , Zhang Ying-Fang , Qu Hua-Sheng , Ren Bing-Xiu
Published: December 2024

Background
Anti-angiogenesis has been recognized as a crucial strategy in anti-tumor therapy, and the early assessment of its efficacy is equally significant. In this study, we developed a magnetic resonance (MR) probe specifically targeting angiogenesis to facilitate targeted imaging for the early evaluation of anti-angiogenic effects.
Methods
We synthesized DOTA-G3CNGRC, conjugated it with gadolinium (III), and subsequently evaluated the labeled probe in vitro. Tumor-bearing mouse models of HT-29 (CD13-negative expression) and HT-1080 (CD13-positive expression) were established, followed by MR Imaging conducted via intraperitoneal injection of the labeled probe and Gd-DOTA at a dosage of 0.5 mg/kg/day before and after ubenimex treatment over a consecutive period of seven days. The average pixel ratio of the transplanted tumor (target tissue, T) to the left hind leg (non-target tissue, NT) was determined using the region of interest technique (ROI), while changes in tumor size were meticulously recorded. Additionally, APN/CD13 expression levels in transplanted tumors were assessed both prior to and following treatment.
Results
The labeling rate of probes was 88.99%. The IC50 of the probes was 61.66 nM. The T/NT ratio of HT-1080 was significantly higher than that of HT-29 (P < 0.001, n = 5). After treatment, the T/NT value of HT-1080 transplanted tumors was significantly decreased (P < 0.001, n = 5), accompanied by a significant decrease in CD13 expression and unapparent changes in tumor size ( P = 0.710, n = 5).
Conclusion
The Gd-DOTA-G3CNGRC probes appeared potential for targeted MR imaging in assessing the early efficacy of anti-APN/CD13 drugs.
RMC-7977 a broad RAS inhibitor increases the sensitivity towards Bortezomib
Authors: Singha Didhiti , Mondal Meghna , Malakar Pushkar
Published: December 2024

The drug Bortezomib commonly treats patients with multiple myeloma. However, its use is more limited in other cancers, such as hepatocellular and cervical cancer. Additionally, reports have indicated cases of resistance to Bortezomib. In this context, studies have demonstrated that Ras signaling plays a significant role in influencing the sensitivity of cancer cells to chemotherapeutic drugs. A new experimental drug called RMC-7977 was made by Revolution Medicines. It targets the active, GTP-bound forms of RAS proteins, such as KRAS, NRAS, and HRAS. Since RMC-7977 is a broad Ras inhibitor recently discovered, we sought to evaluate its efficacy in enhancing the sensitivity of cancer cells to Bortezomib. Our study aimed to assess the effect of RMC-7977 on Bortezomib sensitivity. The results show that HeLa and HepG2 cells exhibit lower sensitivity to Bortezomib compared to RPMI-8266 cells. However, combination therapy with RMC-7977 and Bortezomib increases the sensitivity of HeLa and HepG2 cells to Bortezomib. Cycloheximide has a big effect on the levels of Ras protein in RPMI-8266 cells, but it doesn't change them at all in HeLa and HepG2 cells. These findings underscore the crucial role of Ras signaling in determining sensitivity to Bortezomib. The present study also highlights the potential of the RMC-7977 inhibitor in enhancing the response to Bortezomib. This work could broaden the scope of FDA-approved Bortezomib to include additional cancers beyond multiple myeloma and improve outcomes for patients with chemoresistant multiple myeloma. Furthermore, it may open up new therapeutic applications for the recently discovered RMC-7977.
Dermatologic diseases in Africa: The profile of patients attending a tertiary hospital in the Ashanti Region of Ghana
Authors: Agyei Martin Kofi , Sakyi Samuel Asamoah , Annan John Jude , Norman Betty Roberta , Enimil Anthony Kwame , Senu Ebenezer , Opoku Stephen , Kokuro Collins , Tannor Elliot , Ofori Afua , Effah Alfred , Amoani Benjamin
Published: December 2024

Background
Dermatological diseases are a substantial cause of discomfort, with debilitating effects on the affected person's confidence. However, there is a paucity of data on the prevalence of dermatological diseases and their associated factors in Ghana. We assessed the distribution of dermatological cases, its predictive factors, and common treatment options.
Methods
This observational study included 460 dermatological cases from dermatology unit of Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana over 5 years, from January 2016 to December 2020. A data collection sheet was used to extract sociodemographic data, dermatology diseases and drugs for their management. Statistical analyses were done using SPSS Version 26.0 and GraphPad prism version 8.0. P < 0.05 was considered statistically significant.
Results
The highest proportion of dermatological cases were chronic eczema (14.8%), acne vulgaris (10.2%), atopic eczema (8.3%), folliculitis (6.7%), vitiligo (6.5%) and pityriasis rosea (5.2%). A significant number were also prurigo (3.9%), urticaria (3.7%), epidemic Kaposi sarcoma (3.7%) and infantile seborrhoeic dermatitis (3.0%). The proportion of idiopathic pruritus, alopecia areata, and lichen planus were 2.8%, 2.4% and 2.0% respectively. The proportion of systemic lupus erythematosus (1.7%) and haemangioma (1.7%) were significantly higher among females than compared to males (p = 0.049). Most participants were on cetirizine (43.2%), non-alkali soap (13.5%), ketoconazole cream (12.3%), folic acid/vitamin B12 (9.9%), multivitamin (7.1%), and clindamycin/erythromycin (7.1%).
Conclusion
The common dermatological diseases were chronic eczema, acne vulgaris, atopic eczema, folliculitis, vitiligo and pityriasis rosea. Some dermatological conditions are commoner among females and adulthood. Further future studies are recommended to augment other risk factors predilection to skin diseases in Ghana.
Sex-dependent association of serum alkaline phosphatase with grip strength in adults aged 20-59: NHANES 2013-2014
Authors: Zhang Ziyi , Zhou Jiajie , Ma Anpei , Chen Honggu , Wang Bo , Zhao Guoyang
Published: December 2024

Background
Serum alkaline phosphatase (ALP) plays a crucial role in bone and muscle health. Previous studies have demonstrated that serum alkaline phosphatase (ALP) is closely associated with muscle mass. Nevertheless, the association between serum alkaline phosphatase (ALP) and grip strength remains unclear. This study is designed to investigate whether there exists a connection between serum ALP levels and grip strength among individuals aged 20 to 59 years.
Methods
Utilizing data from the National Health and Nutrition Examination Survey (NHANES) conducted in 2013–2014, a cross-sectional survey design was employed to examine 2,182 adults (54.54% male and 45.46% female) aged between 20 and 59 years. Weight-corrected grip strength served as the dependent variable, while serum alkaline phosphatase (ALP) was identified as the primary variable of interest. The relationships were analyzed using generalized linear models, smooth curve fitting, generalized additive models, and stratified analyses.
Results
We discovered that alkaline phosphatase (ALP) was negatively linked with weight-corrected grip strength. When stratified by gender, age group and race, for all groups except for other races, serum alkaline phosphatase (ALP) were negatively correlated with weight-corrected grip strength. When divided into four groups according to gender and age, serum alkaline phosphatase (ALP) and weight-corrected grip strength showed an N-shaped relationship among male participants aged 20–39 years, and an L-shaped relationship among male participants aged 40–59 years, and among female shows a significant negative correlation regardless of age group.
Conclusions
Our research identified notable gender differences in the association between alkaline phosphatase (ALP) levels and weight-corrected grip strength among participants aged 20 to 59 years. This finding offers new insights and avenues for understanding how serum alkaline phosphatase affects skeletal muscle health.
Spontaneous Regression of Epileptogenic Pilocytic Astrocytoma with FGFR1-TACC1 Fusion
Authors: Horikoshi Ko , Iimura Yasushi , Suzuki Hiroharu , Suzuki Mario , Sugano Hidenori , Kondo Akihide
Published: December 2024

Pilocytic astrocytoma (PA) is the most common pediatric tumor, typically located in the cerebellum, with spontaneous regression observed mainly in patients with neurofibromatosis type 1 (NF1). However, spontaneous regression of PA without NF1 is rarely reported. Here, we describe a case of spontaneous regression of PA without NF1, located in the left frontal lobe with FGFR1-TACC1 fusion, in a 14-year-old boy who presented with intractable epilepsy. Initial MRI revealed a lesion in the left middle frontal gyrus, and subsequent follow-up MRI demonstrated spontaneous regression. Despite this regression, the patient's seizures persisted, leading to epileptic focus resection. Pathological examination confirmed PA with characteristic histological findings and FGFR1-TACC1 fusion. This case suggests that FGFR1-TACC1 fusion may be linked to spontaneous regression of PA, even in the absence of NF1. Surgical intervention may remain necessary in cases of intractable epilepsy associated with PA, regardless of tumor regression.
Screening and verification of specific antibodies against Cysticercus cellulosae by antibody microarray technology
Authors: Duan Rui , Zhao Yuyuan , Li Hongchang , Wang Mengqi , Zhang Dejia , Zhao Yongjun , Liu Xiaolei , Yang Xing , Pang Jianda , Sun Shumin
Published: December 2024

Cysticercosis occurs primarily in economically underdeveloped regions of the world, limiting diagnosis by conventional imaging and serologic tests. In addition, due to the limitations of traditional diagnostic methods, there has been an increased demand for cysticercosis markers with high specificity and sensitivity.In this study, antibody microarray technology was used for high-throughput screening of Cysticercus cellulosae, patient serum, and healthy human serum. Differential expression analysis and cluster analysis identified 271 antibodies with significantly different expression levels. The six antibodies were found to be significantly different in healthy serum compared to patient serum and parasite samples, indicating their potential as markers for the diagnosis of cysticercosis. It will be important for the diagnosis and treatment of this foodborne disease to further develop and utilize these markers.
“Beyond the Incision”: A Case-Control Study on IV and Epidural Preemptive Analgesia in Lumbar Spine Surgery
Authors: Joseph Akhil Xavier , Kashyap Anjana , Thirugnanam Balamurugan , Soni Abhishek , Pai Madhava , Vidyadhara Alia , S Vidyadhara
Published: December 2024

Introduction
Effective pain management in lumbar spine surgery is critical to enhancing postoperative recovery and minimizing complications. Preemptive analgesia, administered either intravenously or epidurally, has shown promise in controlling pain; however, limited data exist comparing the two routes directly to determine the optimal approach for lumbar procedures.
Purpose
To evaluate and compare pain control efficacy, recovery outcomes, and postoperative complications between IV and epidural preemptive analgesia routes in lumbar spine surgeries.
Methods
A retrospective case-control study comparing the efficacy of intravenous (IV) and epidural preemptive analgesia in patients undergoing lumbar spine surgery. Patients undergoing lumbar spine surgery were divided into three groups based on the analgesia route: Epidural, IV and Control respectively. Pain scores, analgesic consumption, and recovery profiles were assessed postoperatively. Statistical analyses, including ANOVA and Chi-square tests, were used to evaluate differences in pain control and recovery outcomes between groups.
Results
Epidural preemptive analgesia demonstrated significantly lower postoperative pain scores and reduced analgesic consumption compared to IV administration in the early post-operative period. Highlighting only a marginal route-specific benefit in lumbar spine surgery.
Conclusion
This study fills a critical gap by directly comparing IV and epidural preemptive analgesia in lumbar spine surgery, providing insights for clinical decision-making. Findings suggest IV analgesia offers comparable pain control to epidural, presenting a safer alternative with fewer procedural risks. Results hold valuable implications for optimizing perioperative care.
LEVEL OF EVIDENCE
Level IV
The optimized efficiency of pulmonary vein isolation shortened the procedure time but did not improve the success rate in paroxysmal atrial fibrillation
Authors: Zhang Ling , Xie Yangjing , Hu Xiaoxia , Ma Dongyu , Huang Ying
Published: December 2024

Background
Pulmonary vein isolation (PVI) is the crucial treatment approach of paroxysmal atrial fibrillation (PAF). The success of PVI primarily depends on several factors, including ablation catheter contact force, ablation lesion depth, catheter stability, and ablation point continuity. This project attempted to systematically examine these elements during PVI and evaluate how variations in these parameters affect the safety and efficacy of catheter ablation in patients with PAF.
Methods
This study conducted a retrospective analysis of four key parameters, force-over-time (FOT), ablation index (AI), breakpoint, and GAP in patients with PAF undergoing PVI treatment during bilateral PVI. The AIFV system (utilizing AI, was employed to analyze raw data from the CARTO3 system), categorizing patients into standardized and non-standardized groups based on whether these ablation parameters simultaneously met predetermined criteria. The study evaluated changes in ablation parameters between the two groups, as well as the success rate of atrial arrhythmias post-ablation and the incidence of complications.
Results
There were no significant differences in general clinical characteristics between the standardized (n = 67) and non-standardized (n = 85) groups. Bilateral PVI was successfully performed in all patients (100%). The standardized group achieved a higher ratio of FOT and AI than the non-standardized group (91.79 ± 5.87% vs. 84.46 ± 12.54%, and 93.42 ± 5.09% vs. 86.78 ± 9.08%, P < 0.001, respectively). The standardized group also exhibited a lower ratio of breakpoints and GAP occurrences (6.02 ± 4.80% vs. 16.82 ± 13.20%, and 0% versus 24.70%, P < 0.001, respectively). The standardized group exhibited fewer ablation points overall and a shorter procedure time compared to the non-standardized group (77.13 ± 9.27 vs. 84.54 ± 15.59, and 36.52 ± 7.03 min vs. 41.21 ± 12.36 min, P < 0.005). There was no significant difference in complications between the two groups (0% vs. 1.17%; P > 0.05). After an average follow-up period of 16.86 ± 3.03 months, the incidence of AF after a single procedure without antiarrhythmic drug therapy was 88.15%. Moreover, 61/67 (91.04%) patients in the standardized group and 73/85 (85.88%) patients in the non-standardized group remained free of AF without significant difference (P > 0.05).
Conclusions
Sustainable PVI remains the cornerstone of the ablation strategy for PAF. Enhancements in the precise control of ablation catheter contact force, the achievement of adequate ablation lesion depth, and the improvement of catheter stability and continuity have the potential to significantly reduce procedural duration. Nonetheless, these advancements have not significantly enhanced the success rate of AF resolution following a single ablation procedure.
Value of APOB/APOA1 ratio in prediction of calcific aortic valve disease
Authors: yuxing Wang , ming Yu , song Yang , jiajie Mei , zhenzhu Liu , hong Geng zhao , wenli Xie , hongyan Wang , nan Niu , peng Qu
Published: December 2024

Background: Calcific Aortic Valve Disease (CAVD) is a prevalent heart valve disease. The ratio of two apolipoproteins with distinct functions (APOB/APOA1) has been proposed as a novel assessment index for the evaluation of cardiovascular diseases. The aim of this article is to discuss the role of lipids parameters such as APOB/APOA1 in CAVD and the risk factors for CAVD, to develop a predictive model for CAVD, and to evaluate the sensitivity and specificity of this model.
Method: Patients who initially presented to the Department of Cardiology of the Second Affiliated Hospital of Dalian Medical University between 1 January 2023 and 31 December 2023 were retrospectively identified and included in the study. Patients were divided into an aortic valve calcification group (111 cases) and a control group (201 cases) based on CT findings. The patients' clinical data, laboratory examination results, and chest CT images were collected and analyzed. A variety of statistical methods were used to analyses risk factors for CAVD in order to construct a CAVD prediction model and to assess its sensitivity and specificity.
Results：Lipid parameters APOA1, APOB/APOA1, cumulative LDL exposure and non-HDL/HDL were significantly associated with aortic valve calcification. Age, history of diabetes, DBP, APOB/APOA1, Cys-c and NLR are identified as independent risk factors for CAVD, and the combination of the above indexes in the prediction of aortic valve calcification was 0.796, corresponding to a sensitivity of 0.769 and a specificity of 0.755.
Conclusion: APOA1, APOB/APOA1, cumulative LDL exposure, and Non-HDL/HDL have been demonstrated to be associated withCAVD. Furthermore, age, history of diabetes mellitus, DBP, APOB/APOA1, Cys-c, and NLR have been identified as valid predictors of CAVD.
“What makes them want to quit?” Motivational reasons for dropout of physics degree program and gender differences in expectations and values
Authors: Mumme Clara , Leipert Laura Marie , Vollmeyer Regina
Published: December 2024

This study investigates the predictive influences of expectations and values that may sustain students’ dropout intention in physics as well as gender differences in students' motivation and intention. Eccles’s expectancy-value model was used to frame the study. The academic self-concept (expectation component) and value components focused on utility value, intrinsic value, and study satisfaction (costs) were examined. A final sample of 61 students (31% female) enrolled in physics courses at a German public university participated. The study was conducted longitudinally with two measurement points within one semester. A regression model revealed that a lower academic self-concept in physics predicted students' intention to drop out. However, subjective values did not predict the dropout intention. With the data collected gender differences were also analyzed. It was found that females had a lower academic self-concept, and lower study satisfaction than males and saw less utility or intrinsic value in physics, while they did not want to drop out more often. The results highlight the need of closing the gap between male and female expectations and values regarding physics. Overall, the findings provide new insights into dropout intention and gender differences in physics. Implications of these findings are discussed.