bluuebunny/crossref_metadata_2025 huggingface dataset:
The use of methods of spatial displacement of the myocardial structure (speckle tracking) to determine the indications for coronary angiography in patients suffering from coronary heart disease
Authors: Kuchmin A. N. , Yaroslavtcev M. Y. , Afendikov N. V. , Galova E. P. , Evsukov K. B. , Morozov S. L. , Shevelev A. A.
Published: July 2021

The indicators of global and segmental longitudinal deformation of the left ventricular myocardium are presented and analyzed in patients suffering from coronary heart disease. The latter, as before, remains one of the urgent diseases of the circulatory system. To verify and determine management tactics for patients suffering from coronary heart disease, coronary angiography is performed. Indications for its implementation are based on the results of exercise tests, in particular, stress echocardiography. However, its implementation can be difficult due to poor visualization of the walls of the left ventricle, and the conclusion is not without subjectivity. One of the modern methods for assessing the contractility of the left ventricular myocardium, both global and segmental, is the spatial displacement of the myocardial structure (speckle-tracking- echocardiography). The technique automatically calculates the longitudinal deformation of the myocardium, expressed as a percentage of the initial values. It was found that the global and segmental longitudinal deformation of the left ventricular myocardium in the majority of the evaluated segments in the examined patients did not differ before loading. When conducting a stress test, the exact opposite dynamics of changes in the parameters of the global and segmental longitudinal deformation of the left ventricular myocardium is observed. So, in patients with a high risk of complications of coronary heart disease, a decrease in these indicators was observed, in patients without a risk of complications, on the contrary, their increase was observed, which indicates an increase in myocardial contractility during physical exertion. It was revealed that the indicator of global longitudinal deformation of the left ventricular myocardium is highly informative. The lower value of the decrease in the global longitudinal deformation of the left ventricular myocardium was calculated, which can serve as an additional indication for coronary angiography.
Measuring instruments metrological monitoring in a medical organization based on a process approach
Authors: Mendel S. A.
Published: July 2021

A model of the process of metrological control of measuring instruments is presented. The model includes 6 or9 stages, depending on the results of metrological control. Based on the list of measuring instruments, a contract is concludedfor metrological control. After the conclusion of the contract, the collection of documents necessary for verification iscollected. Further, the measuring instruments are transferred to an accredited organization. An accredited organization carriesout verification. If, according to the results of verification, the tool is deemed suitable for use, then the stage of obtainingconfirmation of the verification is carried out. The output at this stage will be a verification certificate. If, according to theresults of verification, the measuring instrument is not suitable for operation, then the stage of canceling the verificationcertificate is carried out. The next steps in this case are to receive notice of unsuitability for use and write-off of the measuringinstrument. At this process is considered complete. The target indicators (indicators) of the process are: the measurementerror of specific measuring instruments within the established limits. Monitoring (control) of the process is carried out bya metrology engineer of a medical organization. Control methods are: control of the calibration intervals of measuringinstruments. The model is recommended as a model for use in medical organizations. The use of this model in the presenceof a target indicator (indicator) of the process of metrological control will ensure the necessary quality of metrological workin a medical organization within the framework of the internal quality control system.
Anti-epidemic protection of military from malaria in South-East Asia (for the 15th anniversary of the humanitarian operation to eliminate the consequences of the tsunami in Indonesia)
Authors: Solovev A. I. , Kovalenko A. N. , Tokmakov V. S. , Vasilev V. V.
Published: July 2021

The experience of organizing a system of anti-epidemic measures in the Russian military medical group operating on the territory of the island of Sumatra during the humanitarian operation to eliminate the effects of the tsunami in 2005 is presented. A characteristic of the consequences of a natural disaster, a climatogeographic description of the region is presented. The natural-climatic and socio-economic conditions for the spread of malaria infection in the coverage area of the Russian military medical group are analyzed. Russian military physicians acted in an equatorial climate in a zone of tropical rainforest in a highly endemic area for tropical (P. falciparum) and three-day (P. vivax) malaria, as well as for vector-borne tropical infections such as dengue fever, vuhereriosis, and brugiosis. Among the carriers of malaria parasites and other tropical infections on the territory of about. Sumatra mosquitoes Anopheles sundaicus are of the greatest epidemic importance. In 2005, their mass breeding occurred in late January - early February (1,5-2 months earlier than usual). A system of anti-malarial protection of personnel is described, aimed at reducing the risk of infection of military personnel, preventing the development of the disease and its malignant course, early detection of patients and their effective treatment. There were no cases of malaria among the Russian military personnel during their entire stay in the endemic territory. At the same time, the incidence rate among Indonesian soldiers and local residents was constantly increasing. In hospitals, the number of patients with severe forms of tropical malaria increased. Thus, the effectiveness of the developed system of anti- malarial measures among the military personnel involved in peacekeeping and humanitarian operations in the territory with a continuous season of transmission of malaria infection has been confirmed.
Old new coronavirus
Authors: Moskalev A. V. , Gumilevskiy B. Y. , Apchel V. Y. , Cygan V. N.
Published: July 2021

The main biological characteristics of Coronaviridae viruses, including viruses, severe acute respiratory syndrome and Middle East respiratory syndrome, are presented. The features of immunopathogenesis associated with these infections and their differences from the infection 2019-2020 are analyzed. It is believed that the modern incidence of upper respiratory tract in adults, associated with coronaviruses, is between 10 and 30%. Coronaviruses are ecologically diverse, with the greatest diversity in bats, suggesting that they are the main reservoirs of coronaviruses. Research into the genome of the new coronavirus - 2019-nCoV has shown that it has about 80% nucleotide identity with original viruses of severe acute respiratory syndrome and the ability to bind to angiosine-transforming receptors еnzyme 2. This, along with the high genetic proximity of coronaviruses, indicates their overall origin and overall probable source. However, the receptors of the angiosin-transforming enzyme 2 are the key that gives access to the cell even with low infecting activity. It has been shown that the main diagnostic methods to increase the specificity of detection of a new coronavirus should be variants of polymerase chain reaction and immunoblotting. However, there is still a lot of unknown related to the life of the 2019-nCoV virus. There is a clear identification and comparison of the genomes of the virus in different countries. Identify those genetic inserts that allow the virus to escape from the control of the immune system and turn into a hypervirulent strain. Proving or disprove the possibility of the 2019-nCoV virus is altering its genetic and antigenic potential in different animal species and becoming a new type of virus.
Paraspinal structures of thermoregulation
Authors: Gaivoronskiy I. V. , Rodionov A. A. , Gaivoronskiy A. I. , Gaivoronskaya M. G. , Nichiporuk G. I. , Goryacheva I. A. , Khabibullina N. K.
Published: July 2021

A detailed analysis of the literature on the structure and functions of the paraspinal structures of human thermoregulation involved in maintaining temperature homeostasis is presented. It is shown that in the process of evolution, a peculiar paraspinal morphofunctional complex is formed around the spinal center of thermoregulation, including thermal- generating structures (adipose and muscle tissue); venous thermal distribution rings formed by paraspinal venous plexuses and thermoregulatory nervous apparatus (meningeal and posterior branches of the spinal nerves and their nerve endings). It was found that the heat-generating structures are represented by adipose tissue of the epidural space, adipose tissue of the bone marrow, paravertebral and interscapular adipose tissue, back muscles and intercostal muscles). Bone marrow fatty tissue plays an important role not only in thermoregulation, but also in bone remodeling. Fatty tissue mainly includes components of white and a small amount of brown adipose tissue. Heat from muscles through the venous system of the spinal column affects the functioning of the spinal center of thermoregulation by contractile thermogenesis. It has been shown that around the center of thermoregulation of the spinal cord, venous vessels form four thermal distribution rings. The first of them is the venous bed of the soft membrane of the spinal cord and cerebrospinal fluid of the subarachnoid space; the second is the internal vertebral venous plexus; the third - intraosseous (intraorgan) venous plexuses of the vertebrae; the fourth is the anterior and posterior external vertebral venous plexuses. All four thermal distribution venous rings anastomose among themselves, forming a single thermal distribution system around the spinal center of thermoregulation. The innervation of thermal generating structures and thermal distribution of venous rings is carried out by somatic and autonomic nerve fibers.
Contribution of Professor B.M. Savin to the development ofaviation and space medicine
Authors: Blaginin A. A. , Bukhtiarov I. V. , Pashenko P. S. , Savin A. V.
Published: July 2021

The main milestones of scientific and pedagogical activity, as well as the life path of one of the leading representatives of aviation medicine, Doctor of Medical Sciences, professor, outstanding researcher and wonderful teacher, author of works on the problem of influence of overload and hypervesomity on the body and central nervous system of man- Boris MikhailvichSavin are considered. Separate moments of his participation in the Great Patriotic War before daily work as the head of research department of the Military Medical Academy named after S.M. Kirov are presented. The contribution of Boris Savin to the study of issues related to aviation and space medicine, in particular: the study of the action on the body of overload and the clarification of physiological mechanisms underlying changes in higher nervous activity at accelerations, was analyzed; Studying the state of the central nervous system when exposed to various factors; Development of neuroreflective theory of adverse effect of accelerations on human body. Boris Mikhailvich has made a huge contribution to the development of aviation and space medicine and has entered the history of aviation and space medicine through his research and scientific publications, which include monographs The influence of overload on the functional state of the central nervous system and the mechanism of disruption of its activities and Hypervesomeness and functions of the central nervous system.
Chronic non-viral liver pathology in military personnel exposed to military-professional factors
Authors: Zhirkov I. I. , Gordienko A. V. , Yakovlev V. V. , Serdyukov D. Yu. , Fomichev A. V.
Published: July 2021

Abstract. The prevalence and structure of chronic non-viral liver disease of military personnel whose service is associated with the influence of various military-professional factors are estimated. It is established that the frequency of chronic diffuse liver diseases of viral etiology in a group of servicemen radio-technical troops was 77,3%, from persons engaged in diving and altitude descents 65,9%, pilots of the aerospace defence forces of Russia 62,8%, in persons without exposure to military occupational factors is 69,5%. The largest number of persons suffering from chronic non-viral liver disease in the group of military radio-technical troops, probably related to low levels of physical activity and higher values of body mass index and waist circumference, but also the influence of microwave radiation, can enhance the damaging effects of lipid peroxidation. The lowest prevalence of non-viral chronic diffuse liver diseases among pilots and aquanauts is probably related to the maximum health requirements imposed on military personnel of these categories. It was found that the level of alcohol consumption and the nature of nutrition in the study groups did not significantly differ. The highest values of body mass index and waist circumference in combination with the lowest level of physical activity were observed in the group of military personnel of the radio engineering troops, which is probably due to the nature of daily military service, which is mainly sedentary. Among the metabolic changes of blood serum, increased total cholesterol levels in groups of divers, pilots and military Radio-technical troops compared with a control. In addition, the level of glucose in Aquanauts, as well as triglycerides in soldiers of the radio engineering troops was higher than in the control group. Ultrasound examination in all groups related to the impact of military occupational factors, recorded an increase in the thickness of the left lobe of the liver, and oblique vertical size and thickness of the right lobe in the group of soldiers of the radio-technical troops compared with a control. In addition, the values of the thickness of the intima-media complex as a marker of preclinical atherosclerosis associated with non-alcoholic and alcoholic-metabolic fatty liver diseases in this category of individuals significantly exceed them in the other groups. The maximum level of liver damage in the group of military personnel of radio engineering troops is confirmed by the highest values of the controlled parameter of attenuation of ultrasound, reflecting the degree of liver steatosis.
Percutaneous Urolithiasis Surgery in Military
Authors: Protoshak V. V. , Paronnikov M. V. , Sivakov A. A. , Lukinov K. A. , Kiselev A. O. , Alentiev S. A. , Lazutkin M. V.
Published: July 2021

Abstract. The clinical efficacy and safety of the use of percutaneous techniques in the treatment of kidney stones in 72 servicemen were studied. All percutaneous operations were performed by one operating team. It was found that percutaneous urolithiasis surgery was effective in 88.9% of people. Stone free rate was achieved in 83,8% of military personnel undergoing standard percutaneous nephrolitholapaxy and in 94.3% of patients undergoing minipercutaneous nephrolitholapaxy. With stones larger than 2 cm, the effect was observed in 81.8% of cases with standard surgery and in 96% of patients with mini-percutaneous approach. Percutaneous interventions in military personnel with stones larger than 2 cm were effective in 84,6% of patients with standard surgery and in 90% with mini-percutaneous access. Complications according to the Clavien-Dindo classification were found in 29,1% of servicemen: in 20,8% of cases of standard nephrolitholapaxy and in 8,3% of minipercutaneous nephrolitholapaxy. The bulk of the complications were Grade III 20,8%. Grade III IV were determined less frequently in 8,3% of cases. Urosepsis (Grade IV b) and death (Grade V) were not observed in our study. Duration of labor losses for conscripted servicemen were about 17 days, for contract servicemen when performing standard nephrolitholapaxy 12,8 days, for military personnel with minipercutaneous nephrolitholapaxy 11,2 days. The dismissal rate among conscripts was 18,2%. There were no contractual servicemen who were dismissed from the ranks of the Armed Forces of the Russian Federation, however, 14,7% of servicemen who underwent a standard operation and 11,1% of patients who underwent mini-percutaneous nephrolitholapaxy after surgery needed sick leave for a period of 15 days. In general, percutaneous techniques are common and effective methods of surgical treatment for military personnel suffering from urolithiasis. Mini-percutaneous approach for nephrolitholapaxy is safer than the standard approach, but it is less effective for coral calculi. Percutaneous methods for removing kidney stones are associated with a low rate of dismissal and short recovery times for military personnel.
Effect of atorvastatin on the lipid profile, markers of immune inflammation and symptomatic severity of heart failure in patients with myocarditis
Authors: Ryzhman N. N. , Grishaev S. L. , Cherkashin D. V. , Gladysheva E. V. , Filippov V. Yu. , Kutelev G. G.
Published: July 2021

Abstract. The effect of atorvastatin on the immune system and lipid metabolism after 24-week treatment of patients with chronic myocarditis is considered. Statins have been found to improve the clinical course of heart failure with a preserved ejection fraction in patients with myocarditis: they reduce the functional class of heart failure, improve the systolic function of the heart and its arrhythmogenic potential. Despite the large amount of conflicting data in the field of statin use in heart failure, one can think about the possible influence of molecular differences in statins on their pharmacological and pleiotropic effects. In particular, atorvastatin, which has lipophilic properties, is able to penetrate cardiomyocytes in contrast to hydrophilic rosuvastatin, which may partially explain the positive cardiac effects of atorvastatin in patients with heart failure with a preserved ejection fraction. The probable basis for the positive effect of atorvastatin on morphofunctional parameters in heart failure is its positive pleiotropic effects associated with a decrease in рro-inflammatory immune markers and subsequent leveling of negative neurohumoral activation. An additional mechanism that caused the positive effect of atorvastatin on the clinical course of heart failure can be considered a factor of preservation of systolic function of the left ventricle.
Objective difficulties in differential diagnosis of pneumocystis pneumonia on the background of human immunodeficiency virus infection
Authors: Uliukin I. M. , Shuklina A. A. , Bulygin M. A. , Bulankov Yu. I. , Orlova E. S.
Published: July 2021

Аbstract. The results of two clinical observations with a description of the examination and treatment of patients with infection caused by human immunodeficiency virus, with pneumocystic lung lesions at various stages of the provision of comprehensive care are presented. Since not a single combination of symptoms, clinical signs, and radiological findings is a diagnostic criterion for pneumocystis pneumonia, its diagnosis is currently mainly based on microscopic visualization of characteristic forms on stained airway preparations. The problem of treating pneumocystis pneumonia is determined by a very narrow range of active drugs available on the market, despite the fact that there is practically no data on the growth of resistance of clinically significant pneumocysts. Defects in the provision of medical care in both cases were a violation of the order and timing of the dispensary, in particular, and the lack of medical monitoring of the structures that monitor the health of patients, in general. Therefore, in the context of an increase in the total number of patients with infection caused by human immunodeficiency virus, and the manifestation of secondary diseases in them, the leading of which is tuberculosis, it is necessary to develop and implement additional professional programs for the early detection, in particular, lung lesions, as part of a continuing medical education for general practitioners, general practitioners and doctors of other specialties providing assistance in organizations of primary health care.
Сlinical use of immune plasma in septic conditions
Authors: Skripay L. A. , Vilyaninov V. N. , Belgesov N. V.
Published: July 2021

Abstract. The effectiveness of clinical use of immune plasma in comparison with conventional fresh-frozen plasma in septic conditions is considered. It was found that the use of immune plasma in the treatment of patients suffering from septic complications, against the background of antibiotic therapy, is more effective than the use of conventional freshly frozen plasma. In patients who received immune plasma transfusions, there was a significant decrease in the inflammatory response of the blood (decrease in leukocytosis, erythrocyte sedimentation rate, C-reactive protein), and the level of procalcitonin also decreased. The level of total protein, on the contrary, increased after each transfusion of this component. In patients who received fresh frozen plasma transfusion, there were no positive changes in the indicators of inflammatory blood reaction (the number of white blood cells and the rate of erythrocyte sedimentation after each transfusion increased, changes in C-reactive protein were insignificant). The level of procalcitonin and total protein increased after each infusion. In all patients who were transfused blood components, against the background of antibiotic therapy, the result of treatment was also influenced by the number of microorganisms seeded from the wound surface during primary bacteriological seeding. In General, in septic conditions, transfusion of immune plasma was more effective than transfusion of freshly frozen plasma. This effect on normalization of laboratory blood parameters was observed with a smaller average volume of transfused immune plasma (0,58 l) compared to a larger average volume (0,83 l) of transfused freshly frozen plasma.
Аpplication of the mathematical model of human torso for modeling abbreval influence in wound ballistics
Authors: Denisov A. V. , Stepanov M. D. , Haraldin N. A. , Stepanov A. V. , Borovkov A. I. , Zhukov I. E. , Kurinnoy E. D. , Tsurikov S. G.
Published: July 2021

Abstract. In the work, a review of scientific articles on the behavior of tissues and organs of the human body under local mechanical effects on it, as well as a description of the physico-mechanical properties of biological materials. The selection of mechanical behavior for each biological material as part of a mathematical model of the human torso was carried out, its finite element model was created, validation experiments were modeled using data presented in the literature. An original calculation model of a human torso with a tuned interaction of organs with each other was developed. Contact interaction parameters are determined. The developed computational model of a human torso was verified based on data from open sources for an experiment with mechanical action by a cylindrical impactor. An algorithm for processing pressure and acceleration graphs has been implemented in order to obtain tolerance curves. A specialized modular program has been created for the automated processing of calculation results and the output of the main results. 42 numerical tests were carried out simulating the entry of a steel ball into each of 21 zones for power engineers of 40 and 80 J. According to the results of the tests for each organ, pressure and acceleration tolerance curves were obtained, animations of the behavior of organs under shock were created, visualization of the pressure field propagation in organs was obtained torso.
Prospects for improving pre-hospital care for wounded with gunshot penetrating wounds to the chest
Authors: Golovko K. P. , Markevich V. Yu. , Suprun T. Yu. , Vertiy A. B. , Komyagin S. E. , Zhirnova N. A. , Samokhvalov I. M.
Published: July 2021

Abstract. The analysis of injuries, life-threatening consequences and outcomes of treatment of wounded with penetrating chest wounds and the results of approbation of a prototype (medical) disposable set UD-02v for the elimination of strained and open pneumothorax, hemothorax, pleural drainage and collection of spilled blood with the possibility of subsequent reinfusion at the pre-hospital stage is presented. The prototype of the UD-02v set was created as part of the implementation of the state defense order in 2018. Its creation is due to the fact that despite the improvement of medical care at the stages of medical evacuation and the widespread use of individual armor protection, chest injuries currently remain a frequent type of combat surgical injury, accounting for 6 to 12% of all injuries. The main cause of death of injured and injured with chest injuries remains blood loss caused by continuing intrapleural bleeding and concomitant damage to other anatomical areas. Stressful pneumothorax, together with intrapleural bleeding, account for 93% of preventable causes of fatal chest injuries at the pre-hospital stage. Untimely elimination of the consequences of severe breast injuries should be considered as a negative factor affecting the outcome of treatment, and significant improvement in treatment results should be expected only in the case of early elimination of the most severe consequences of breast injuries. The developed set of UD-02v exceeds foreign medical devices in its medical and technical characteristics, and is the most promising for acceptance for the supply of the Armed forces of the Russian Federation as part of the samples of complete and service equipment.
Maxim SemenovichSubbotin – the founder of asepsis and antiseptics in Russia, an outstanding surgeon, scientist, inventor, teacher
Authors: Kosachev I. D. , Ivanus S. Ya. , Zubarev P. N. , Golovanov P. A.
Published: July 2021

Abstract. Brief biographical information about Maxim SemenovichSubbotin, the founder of aseptic and antiseptic in Russia, is provided. In 1884, M.S. Subbotin heads the Department of Surgical Pathology at Kharkov University. In addition to scientific and pedagogical activities, he will devote a lot of time to the organizational issues of the clinic. He uses the surgical department of a military hospital as a clinical base for training students at Kharkov University. In addition to the course of surgical pathology with desmurgy, he also conducts a course of surgical surgery, and since 1887, a parallel course of the faculty surgical clinic. However, teaching and scientific work in a small clinic (25 beds) could not satisfy Maxim Semenovich, since by this time he had formed into a major surgeon and scientist, ready for wide surgical and scientific activities. Becoming the head of the Department of Surgical Pathology of the Imperial Medical and Surgical Academy (1890) M.S. Subbotin began its reorganization according to the requirements of asepsis. He organized a new dressing room, the walls and ceilings of which were painted with light oil paint, the floor is covered with ceramic tiles.An operating unit began to function, consisting of two operating rooms, a sterilization room, a bathroom and a material room. A laboratory was established to conduct research and control operations. The clinic strictly and sequentially carried out sterilization of instruments, dressings, processing of the surgical field. M.S. Subbotin studied the effect of carbolic acid on the body, used it to treat wounds. He created his own tent for operations, invented a sterilizer oven, a catgut sterilizer with dry steam, an autoclave, and hemorrhoidal forceps. M.S. Subbotin invented a drainage pump for the treatment of purulent cavities, first made thoracoplasty with pleural empyema. He introduced aseptic and antiseptic into surgical practice. Created a scientific surgical school: P.I. Bukhman, S.S. Girgolav, L.V. Orlov, N.N. Petrov, N.A. Schegolev and others
The second life of the small anatomical collection of F. Ruysch «The eighth wonder of the world»
Authors: Gaivoronsky I. V. , Nichiporuk G. I. , Tvardovskaya M. V.
Published: July 2021

Abstract. In November 2019, an important historical event was held. A small collection of F. Ruysch, which is stored in the fundamental Museum of the Department of normal anatomy of the Military medical Academy named after S. M. Kirov, has received a second life, thanks to friendly scientific relations between Military medical Academy and the University of Leiden. The unique collection of anatomical preparations, which Peter I called The Eighth wonder of the world, was created by the great Dutch anatomist, doctor of medicine, Professor of anatomy and botany at the University of Amsterdam F. Ruysch. A large collection was acquired by Peter I in 1717 specifically to the future of the Kunstkammer (now the Museum of Peter the Great) and taken to Russia under the supervision of the first President of the Petersburg Academy of Sciences L.L. Blumentrost. Small collection of F. Ruysch was presented to Peter I in the late seventeenth century (1697). It has withstood more than 300-year storage period. Numerous movements and different storage conditions, of course, left its mark on the appearance of these precious unique anatomical specimens. The last event of violations were associated with the early repair of the anatomical building of the Military medical Academy.We must pay tribute to the enthusiasm and unselfishness of the staff of Leiden University headed by a great friend of Russia I.F. Hendriks, who was able to organize a team of professionals in the Museum business. This team included the head of Leiden University, Professor P.C.W. Hodendoorn and specialist in restoration and percussively anatomical preparations A.J. Van Dam. Hard work was multi-stage. First conducted a thorough verification of anatomical specimens of F. Ruysch with the existing directories of the Departments records. Identification of the preparations to the F. Ruysch collection was carried out by the appearance of containers, labels, appearance of preparations, the study of embalming fluid. Photo documentation of each study drug was accompanied by reports signed bilateral commission. After pre-treatment the special chemicals and equipment were delivered, and conducted direct work on restoration and percussively. It lasted 10 days. Members of the Department received a unique master class on the restoration of wet embalmed museum anatomical specimens, and received recommendations for their storage.
Scientific works of Professor T.Ya. Aryev – the first head of the department of thermal lesions of the Military Medical Academy them. CM. Kirov for the period 1932–1945
Authors: Sokolov V. A. , Mamaeva S. A. , Butrin Ya. L.
Published: July 2021

Abstract. The subject of scientific research of the first head of the department of thermal lesions of the Military Medical Academy. CM. Kirov Professor Tuviy Yakovlevich Aryev. The presentation of the material is carried out in chronological order and is tied to those events that occurred in the life of a then-young scientist. The role of family members and scientific leaders in choosing a specialty, making a decision on the beginning of scientific work and the research topic, which has become central during the historical period under consideration, is shown. The high quality of the research is indicated by the publication of the results of T.Ya. Aryev in German and French scientific journals. The growth of professional skills was facilitated by the admission to the Department of General Surgery at the Military Medical Academy. The role of the head Professor S.S. Girgolava manifested itself in the fact that two years after the start of research, the monograph Frostbite was written, and a dissertation was successfully defended a year later. The knowledge gained, the development of the principles and methods of performing scientific work have become an integral feature of T.Ya. Aryeva. Even during a business trip to the armed conflict zone on the Halki-Gol River, he was able to collect material and perform a number of works related to the characteristics of surgical combat trauma of that period. The subsequent analysis of the results of the treatment of wounded with frostbite during the Soviet-Finnish War formed the basis for the development of fundamentally new proposals for the prevention, diagnosis and medical care of victims of frostbite at the stages of medical evacuation. New techniques have contributed to increasing the effectiveness of medical support for troops during the Great Patriotic War.
Intraoperative multi-pulse transcranial electric stimulation: the effect of general anesthetics impact on the excitability of the pyramidal tract
Authors: Toporkova O. A. , Aleksandrov M. V. , Nazarov R. V. , Chernyj V. S.
Published: July 2021

The results of intraoperative neurophysiological monitoring during neurosurgical treatment of pathological processes in the central nervous system are analyzed. The mechanisms of action of general anesthetics on the excitability of the pyramidal system during anesthesia with propofol and sevoflurane have been clarified. It has been established that anesthetics with different mechanisms differ in their effect on excitability and conductivity in the system motor neuron of the cortex pathways alpha-motor neuron. Inhalation anesthetic sevoflurane causes a slowdown in the conduction of a nerve impulse and a violation of the mechanisms of convergence of excitation on the alpha-motor neuron of the spinal cord. In this regard, during general anesthesia with sevoflurane, in order to achieve the effectiveness of transcranial electrical stimulation, the number of stimuli in the package should be increased first with a relatively high stimulation current. Under general anesthesia with propofol, the processes of convergence of excitation are not inhibited, therefore, effective electrical stimulation is achieved by increasing the stimulation current with a stable number of stimuli. With an increase in doses of general anesthetic to a level at which periodic patterns are recorded on the electroencephalogram, a deep inhibition of the excitability and conductivity of the pyramidal system occurs. Under these conditions, effective performance of transcranial electrical stimulation is achieved with submaximal values of the current strength and the number of stimuli.
Methods for studying genetic modifications
Authors: Moskalev A. V. , Gumilevskiy B. Yu. , Apchel V. Ya. , Tsygan V. N.
Published: July 2021

Objects and modern methods of genome editing are considered. The immune system of prokaryote and their protective mechanisms that prevent the purposeful editing of the genome for the benefit of the researcher is characterized. This mechanism in prokaryotes are cluster regulatory interspatial short palindrome repetitions. The number of such repetitions varies from object to object, which ultimately makes it impossible to get the perfect standard model. Three types of such systems that have their own mechanism for generating proteins have now been identified. The proteins, which are now most commonly used to edit the genome and identify areas of proto-special adjacent motifs, are described. Detailed characteristics of the organization of the immune system prokaryote and phases of its activity are given. Three types of short-palin re-recurrence systems have now been identified, and the teams are being identified as cluster regulatory interspatial short palindrome repetitions-Cas9. Each system uses its own mechanism to generate proteins that catalyze the fission of nucleic acids. The type II cluster regulatory interspatial short palindrome repetitions system is most commonly used, better adapted to edit the genome because of its simplicity. It has been established that the cluster regulatory interspatial short palindrome repetitions-Cas9 system can be used for point editing of the genome and in eukaryotes. This is done either through non-homological annexation of the end, or by homologically directed reparation. A promising variant of genetic modeling is the use of the enzyme-endonuclease Cpf1, which is the effector protein of the cluster regulatory interspatial short palindrome repetitions-Cas V type systems. Cpf1 is smaller than the enzyme protein Cas9 and for the system to function only require specers of ribonucleic acid, without additional ribonucleic acid. Unlike Cas9, which cuts both chains of deoxyribonucleic acid in the same place, Cpf1 generates an incision, creating ticky ends that can be used to insert interesting sequences by complementing and ligation. It is likely that the system using the enzyme-endonuclease Cpf1 will be more convenient than the system where the protein is used Cas9, as the range of editing of the controlled genome of ribonucleic acid is expanded to make the necessary edits.
Turkic Poetic Passages Written in Uyghur Vertical Script from the Collection of the Institute of Oriental Manuscripts, RAS
Authors: Kozintcev Mark A.
Published: July 2021

The article contains photos housed at the Photograph Collection of the Institute of Oriental Manuscripts RAS (folder Appendix No. 2, shelf mark ФВ-277/10) and their description. The photos feature short texts written in Uyghur vertical script on the margins of an unknown manuscript. The language of the manuscript itself is unknown, although some photos let us presume that it used the Arabic script. The texts on the photos are accompanied by their transcriptions in Cyrillic and Arabic letters made by W. Radloff. Examination of the verses has shown that they belong to several authors, including masters of medieval Turkic poetry.
Effect Incorporated of Oat and Corn Cob Powder on Physicochemical and Sensory Properties of Putu Piring
Authors: Ahmad Fisal , Ismail Nur Ezzliana , Chilek Tuan Zainazor Tuan , Zamri Amir Izzwan , Zainol Mohamad Khairi Mohd , Wahab Rahijan Abdul , Hamid Mansoor Abdul
Published: July 2021

The growing consumer demand for healthy food products has turned the interest of industry and researcher in the development of foods enriched with fibre source. Oat and corn cob powder is one of the fibre sources that rich in insoluble fibers, such as cellulose, hemicellulose and lignin which beneficial the consumer in many ways for a healthy diet. The objective of this study was to investigate the effect of oat and corn cob powder incorporation on the sensory acceptability and physicochemical properties of putu piring at different levels of percentage ratio of oat and corn cob (control 0 percent OP: 0 percent CCP A, 0 percent OP: 100 percent CCP B, 30 percent OP:70 percent CCP C, 50 percent OP:50 percent CCP D, 70 percent OP:30 percent CCP E and 100 percent OP: 0 percent CCP F). Physical analysis showed that the colour of putu piring for L* value ranges from 74.17 to 19.76, a* value ranges from 0.23 to 1.90 and b* value ranges from 13.97 to 20.65. Sensory evaluation results showed that putu piring control (formulation A) scored the highest and no significant different (p lower than 0.05) compare followed by 30 percent OP: 70 percent CCP (formulation C) and 50 percent OP: 50 percent CCP (formulation D) in all attributes being evaluated. Proximate analysis showed that putu piring incorporated with oat and corn cob powder has significantly different (p lower than 0.05) in terms of crude fibre content. It is interesting to note that the incorporation of oat and corn cob powder yielded putu piring can improves the nutritive value of the product to become high fibre products.
The Influence of Non-Newtonian Model on Properties of Blood Flow Through a Left Coronary Artery with Presence of Different Double Stenosis
Authors: Kadhim Saleem K. , Al-Azawy Mohammed G. , Ali Sinan Abdul-Ghafar , Kadhim Mina Qays
Published: July 2021

Cardiovascular diseases were the main cause for loosing lives in the last decades due to the restricted blood flow states in the blood vessels areas. Numerical investigations have been conducted as the aim of this work to examine the blood flow, and wall shear stresses adjacent to the mono stenosis up to different degrees involved in the main, side and distal main branches as well as observe the pulsatile flow of blood in the left coronary artery through various percentage of stenosis. Both the Carreau non-Newtonian rheological model and the Newtonian model were utilized to model the blood fluid and wall shear stresses of left coronary artery, in a row, all the calculated data were validated with the previously published papers. It was found that the blood flow inside areas of the artery lie within the range of non-Newtonian rheological effects can be present, verifying the need to treat blood as non-Newtonian fluid; especially, with the case of 90% blockage.
Parametric Investigation on Single Cylinder Spark Ignition Engine Fueled Methanol Blends; Water-Based Micro Emulsions and Conventional Gasoline
Authors: Qadiri Ufaith , Pasha Amjad Ali , Rahman Mustafa Mutiur , Raheem Mohammed Abdul , Jameel Abdul Gani Abdul , Pillai Subramania Nadaraja
Published: July 2021

In this contribution, the investigation conducted on alternative fuels includes methanol 20% blended with gasoline 80% and emulsion-based fuel with the composition of gasoline 80%, ethanol 15%, and H2O 5% are compared with 100% conventional gasoline fuel. These fueled single-cylinders spark ignition engine is studied for checking their performance and emission characteristics as per future emission norms. This work is performed on One-dimensional AVL Boost Simulation Software. The simulations predicted the performance and emission characteristics were far lesser than conventional 100% gasoline. These fuels meet the strict emission regulations of Euro VII. The main purpose of this investigation is to use alternative fuels to improve the performance and emission characteristics of the single- cylinder spark ignition engine and reduce the consumption of fossil fuel reserves. This investigation led to the conclusion that by using methanol 20% in 80% gasoline and micro-emulsion, fuel improves the power, BSFC (brake specific fuel consumption), thermal efficiency and combustion properties of the single-cylinder spark-ignition engine. The CO, HC and NOx emissions were also reduced for alternative fuel than 100% gasoline fuel. The novel water-based emulsion fuel showed the lowest value of NOx emissions as compared to blended 20% methanol with 80% gasoline and 100% gasoline fuel.
Special aspects of strain localization during thermal power processing
Authors:   Togliatti State University, Rastorguev D. A. , Semenov K. O. ,   Togliatti State University
Published: July 2021

The paper considers the issues of ensuring the uniformity of strain of axisymmetric long-dimensional samples during thermal force processing (TFP), which is the simultaneous application of force and temperature effects for comprehensive improvement of geometric characteristics and physical and mechanical parameters of the workpiece material. This technology is used at various stages of technological processes of parts manufacturing, but its main task is to ensure the axis straightness and the specified distribution of residual technological stresses at the procuring stage. The disadvantage of TFP is that the axial deformation proceeds nonuniformly along the workpiece axis. The core process parameter is the deformation, the control of which is a key factor ensuring the TFP efficiency. The authors studied the plastic strain distribution over the sections of long-length workpieces with different deformation degrees. The study involved the assessment of strain uniformity over the workpiece sections, taking into account the stage of the stress-strain relation at the end of the loading cycle. Based on the concepts of plastic deformation as an auto-wave process, the authors selected the range of technological modes corresponding to the most uniform strain distribution along the workpiece axis with complete processing of the entire workpiece volume. This range corresponds to the stage of parabolic hardening of the plastic flow curve with the formation of the maximum number of stationary zones of localized plasticity. Rheological modeling allows identifying the control points that specify the boundaries of the plastic flow curve stages at various loading parameters, including temperature. To improve the reliability of determining the actual deformation under production conditions, the authors proposed modernizing the TFP process monitoring method by fixing the deformation on a limited workpiece section using the optical technique. The statistical analysis of the strain distribution over the sections for the samples confirms the correctness of this approach. The application of the proposed control method will ensure the most uniform distribution of plastic deformation due to the reliable enter of the workpiece deformation to the range of strain values corresponding to the stage of parabolic hardening of the plastic flow curve.
A Legislative/Legal History of Prescription Drug Advertising and Promotion Regulation
Authors: Li Stephen , Gibbs Iris
Published: July 2021

Purpose: The communication by pharmaceutical companies of promotional messages about their products has long been controversial, but deemed to be necessary by the pharmaceutical industry so that health care professionals and in some cases patients/consumers can be made aware of the latest developments through the communication vehicles they are accustomed to seeing – in the case of health care professionals, through medical advertising, direct mail, visits by company representatives, and attendance at medical meetings, and in case of patients, through the news media and television advertising. On the other hand, critics argue that such promotion, which sometimes reduces complex medical issues to advertising slogans, is inappropriate for products intended to treat and cure diseases, and that health care professionals should learn about new products from peer-reviewed medical literature.  Consequently, advertising, and promotional programs are heavily regulated by the U.S. Food and Drug Administration (FDA). However, the laws themselves raise constitutional issues of infringement on free speech.  Over the past few years, a number of lawsuits have been decided that help clarify the role of the FDA and the extent of its authority in regulating what companies or their employees say about their products. These court decisions are important because they help define how health care professionals and patients/consumers receive medical information. Methods: This overview is intended to identify, in non-technical language, some of the more controversial and challenging issues involved in the FDA’s efforts to regulate marketing communications by drug companies and how the courts view them. Results: The recent lawsuits often involve complex and far-reaching legal issues.  But when examined in toto, as this paper does, they have reflected a view by the courts that truthful and non-misleading statements by drug companies about their products can be legally communicated even when the medical information is not formally approved by the FDA and included in the FDA-approved labeling.  The lawsuits thus have led to an environment in which the FDA continues to oversee with great fervor the activities of drug companies in communicating medical information but at the same time having some flexibility in keeping health care professionals and patients up to date with th latest information about medical research and new therapeutic products. Conclusion: How pharmaceutical products are marketed has been deemed by the U.S. Congress to be important enough to need to be subject to federal regulation.  The issues create a tension between the need for medical information to be accurate and balanced, and the guarantees of free speech.  This review provides an important perspective on how this tension is being resolved, even as dramatic advances in both medical products and technology create new challenges.