bluuebunny/crossref_metadata_2025 huggingface dataset:
A Structural Model for the Core Nup358-BicD2 Interface
Authors: Gibson James M. , Zhao Xiaoxin , Ali M. Yusuf , Solmaz Sozanne R. , Wang Chunyu
Published: September 2023

Dynein motors facilitate the majority of minus-end-directed transport events on microtubules. The dynein adaptor Bicaudal D2 (BicD2) recruits the dynein machinery to several cellular cargo for transport, including Nup358, which facilitates a nuclear positioning pathway that is essential for the differentiation of distinct brain progenitor cells. Previously, we showed that Nup358 forms a “cargo recognition α-helix” upon binding to BicD2; however, the specifics of the BicD2-Nup358 interface are still not well understood. Here, we used AlphaFold2, complemented by two additional docking programs (HADDOCK and ClusPro) as well as mutagenesis, to show that the Nup358 cargo-recognition α-helix binds to BicD2 between residues 747 and 774 in an anti-parallel manner, forming a helical bundle. We identified two intermolecular salt bridges that are important to stabilize the interface. In addition, we uncovered a secondary interface mediated by an intrinsically disordered region of Nup358 that is directly N-terminal to the cargo-recognition α-helix and binds to BicD2 between residues 774 and 800. This is the same BicD2 domain that binds to the competing cargo adapter Rab6, which is important for the transport of Golgi-derived and secretory vesicles. Our results establish a structural basis for cargo recognition and selection by the dynein adapter BicD2, which facilitates transport pathways that are important for brain development.
A Sustainable Evaluation Study Based on Emergy–Geographic Information System (GIS) Methodology in Hangzhou City from 2010 to 2035
Authors: Liu Lan , Cai Runhui , Zhang Junxue
Published: September 2023

Sustainability studies are vital for the long-term development of ecological cities. For cities, single qualitative or quantitative evaluation studies cannot effectively illustrate the ecological and sustainable status of a city. This study employs the emergy–geographic information system (GIS) method to conduct a sustainability evaluation of a city, so as to effectively verify the evaluation results. The emergy method and GIS are both commonly used approaches to address urban issues, but their synergistic effect has rarely been considered, explored, and utilized in urban planning. This study aims to investigate this effect on Hangzhou city through comparative analysis. The results show that rain (geopotential energy) and rain (chemical potential energy) have the highest emergy values from 2000 to 2035, followed by solar emergy, wind emergy, and geothermal heat emergy. These findings are also supported by the GIS map that shows a similar pattern with renewable emergy. Using the five plots (cropland, woodland, grassland, water area, and built-up land) on the GIS map as examples, the accuracy of emergy calculation results for Hangzhou city can be verified, demonstrating the effectiveness of the emergy–GIS methodology. This research provides practical recommendations for city designers and professionals worldwide on urban sustainability. By incorporating both emergy and GIS methods, cities can make informed decisions toward achieving environmentally sustainable development.
Characterization of Cell Surface Glycan Profiles in Human and Mouse Corneas Using Lectin Microarrays
Authors: Martínez-Carrasco Rafael , Argüeso Pablo
Published: September 2023

The advent of high-throughput sequencing technologies has facilitated the profiling of glycosylation genes at a single-cell level in complex biological systems, but the significance of these gene signatures to the composition of the glycocalyx remains ambiguous. Here, we used lectin microarrays to characterize the composition of cell surface glycans in human and mouse corneas and determine its relationship to single-cell transcriptomic data. Our results identify a series of cell surface glycan signatures that are unique to the different cell types of the human cornea and that correlate, to a certain extent, with the transcriptional expression of glycosylation genes. These include pathways involved in the biosynthesis of O-glycans in epithelial cells and core fucose on stromal and endothelial cell surfaces. Moreover, we show that human and mouse corneas display some structural differences in terms of cell surface glycan composition. These results could provide insights into the specialized function of individual cell types in the cornea and foster the identification of novel cornea-specific biomarkers.
Polyarginine Cell-Penetrating Peptides Bind and Inhibit SERCA2
Authors: Lunde Per Kristian , Manfra Ornella , Støle Thea Parsberg , Lunde Marianne , Martinsen Marita , Carlson Cathrine Rein , Louch William E.
Published: September 2023

Cell-penetrating peptides (CPPs) are short peptide sequences that have the ability to cross the cell membrane and deliver cargo. Although it is critical that CPPs accomplish this task with minimal off-target effects, such actions have in many cases not been robustly screened. We presently investigated whether the commonly used CPPs TAT and the polyarginines Arg9 and Arg11 exert off-target effects on cellular Ca2+ homeostasis. In experiments employing myocytes and homogenates from the cardiac left ventricle or soleus muscle, we observed marked inhibition of Ca2+ recycling into the sarcoplasmic reticulum (SR) following incubation with polyarginine CPPs. In both tissues, the rate of SR Ca2+ leak remained unchanged, indicating that protracted Ca2+ removal from the cytosol stemmed from inhibition of the SR Ca2+ ATPase 2 (SERCA2). No such inhibition occurred following treatment with TAT, or in preparations from the SERCA1-expressing extensor digitorum longus muscle. Experiments in HEK cells overexpressing individual SERCA isoforms confirmed that polyarginine incubation specifically inhibited the activity of SERCA2a and 2b, but not SERCA1 or 3. The attenuation of SERCA2 activity was not dependent on the presence of phospholamban, and ELISA-based analyses rather revealed direct interaction between the polyarginines and the actuator domain of the protein. Surface plasmon resonance experiments confirmed strong binding within this region of SERCA2, and slow dissociation between the two species. Based on these observations, we urge caution when employing polyarginine CPPs. Indeed, as SERCA2 is expressed in diverse cell types, the wide-ranging consequences of SERCA2 binding and inhibition should be anticipated in both experimental and therapeutic settings.
Characteristics of Human Nasal Turbinate Stem Cells under Hypoxic Conditions
Authors: Kim Do Hyun , Kim Sun Hong , Park Sang Hi , Kwon Mi Yeon , Lim Chae-Yoon , Park Sun Hwa , Gwon Kihak , Hwang Se Hwan , Kim Sung Won
Published: September 2023

This study investigated the influence of hypoxic culture conditions on human nasal inferior turbinate-derived stem cells (hNTSCs), a subtype of mesenchymal stem cells (MSCs). It aimed to discern how hypoxia affected hNTSC characteristics, proliferation, and differentiation potential compared to hNTSCs cultured under normal oxygen levels. After obtaining hNTSCs from five patients, the samples were divided into hypoxic and normoxic groups. The investigation utilized fluorescence-activated cell sorting (FACS) for surface marker analysis, cell counting kit-8 assays for proliferation assessment, and multiplex immunoassays for cytokine secretion study. Differentiation potential—osteogenic, chondrogenic, and adipogenic—was evaluated via histological examination and gene expression analysis. Results indicated that hNTSCs under hypoxic conditions preserved their characteristic MSC phenotype, as confirmed by FACS analysis demonstrating the absence of hematopoietic markers and presence of MSC markers. Proliferation of hNTSCs remained unaffected by hypoxia. Cytokine expression showed similarity between hypoxic and normoxic groups throughout cultivation. Nevertheless, hypoxic conditions reduced the osteogenic and promoted adipogenic differentiation potential, while chondrogenic differentiation was relatively unchanged. These insights contribute to understanding hNTSC behavior in hypoxic environments, advancing the development of protocols for stem cell therapies and tissue engineering.
Correction: Zhang et al. Parkin, as a Regulator, Participates in Arsenic Trioxide-Triggered Mitophagy in HeLa Cells. Curr. Issues Mol. Biol. 2022, 44, 2759–2771
Authors: Zhang Zhewen , Yi Juan , Xie Bei , Chen Jing , Zhang Xueyan , Wang Li , Wang Jingyu , Hou Jinxia , Wei Hulai
Published: September 2023

In the published publication [...]
AI-Powered Renal Diet Support: Performance of ChatGPT, Bard AI, and Bing Chat
Authors: Qarajeh Ahmad , Tangpanithandee Supawit , Thongprayoon Charat , Suppadungsuk Supawadee , Krisanapan Pajaree , Aiumtrakul Noppawit , Garcia Valencia Oscar A. , Miao Jing , Qureshi Fawad , Cheungpasitporn Wisit
Published: September 2023

Patients with chronic kidney disease (CKD) necessitate specialized renal diets to prevent complications such as hyperkalemia and hyperphosphatemia. A comprehensive assessment of food components is pivotal, yet burdensome for healthcare providers. With evolving artificial intelligence (AI) technology, models such as ChatGPT, Bard AI, and Bing Chat can be instrumental in educating patients and assisting professionals. To gauge the efficacy of different AI models in discerning potassium and phosphorus content in foods, four AI models—ChatGPT 3.5, ChatGPT 4, Bard AI, and Bing Chat—were evaluated. A total of 240 food items, curated from the Mayo Clinic Renal Diet Handbook for CKD patients, were input into each model. These items were characterized by their potassium (149 items) and phosphorus (91 items) content. Each model was tasked to categorize the items into high or low potassium and high phosphorus content. The results were juxtaposed with the Mayo Clinic Renal Diet Handbook’s recommendations. The concordance between repeated sessions was also evaluated to assess model consistency. Among the models tested, ChatGPT 4 displayed superior performance in identifying potassium content, correctly classifying 81% of the foods. It accurately discerned 60% of low potassium and 99% of high potassium foods. In comparison, ChatGPT 3.5 exhibited a 66% accuracy rate. Bard AI and Bing Chat models had an accuracy rate of 79% and 81%, respectively. Regarding phosphorus content, Bard AI stood out with a flawless 100% accuracy rate. ChatGPT 3.5 and Bing Chat recognized 85% and 89% of the high phosphorus foods correctly, while ChatGPT 4 registered a 77% accuracy rate. Emerging AI models manifest a diverse range of accuracy in discerning potassium and phosphorus content in foods suitable for CKD patients. ChatGPT 4, in particular, showed a marked improvement over its predecessor, especially in detecting potassium content. The Bard AI model exhibited exceptional precision for phosphorus identification. This study underscores the potential of AI models as efficient tools in renal dietary planning, though refinements are warranted for optimal utility.
Effect of Pore Evolution on Thermal Diffusivity and Radiation Characteristics of Thermal Barrier Coatings after High-Temperature Exposures
Authors: Xu Zhou , Xu Shuheng , Zhang Qiukun , Xu Jianfei , Ye Dongdong
Published: September 2023

Studying the impact of pores is crucial to enhancing the service performance of coatings, since they are a typical microstructure feature of thermal barrier coatings. In this paper, a coating prepared by the APS method was employed as the study object, and a scanning electron microscope and optical microscope were used to calculate the porosity after spraying or high-temperature exposures. Based on this, numerical calculations and simulations were used to evaluate the impacts of the pore structure and porosity on the heat conductivity and radiation characteristics of the coating. The results showed that, at high-temperature exposures, the horizontal pores inhibited thermal conductivity and radiation, but the column pores increased heat conductivity and radiation. The heat conductivity of the coating linearly decreased as the porosity increased, whereas the extinction coefficient increased, although at a slower and slower pace. When the porosity reached 15%, if the porosity was further increased, the thermal radiation energy did not change much, indicating that increasing the porosity would only block the heat radiation to a certain amount. This new and time-saving technique for materials research utilizing simulation and numerical computing may be utilized to optimize the microstructure of coatings to increase their service performance.
The Spinodal Decomposition of Ferrite in 2507 Biphasic Stainless Steels: Embrittlement and Possible Toughness Recovery
Authors: Rivolta Barbara , Gerosa Riccardo , Panzeri Davide , Mariani Enrico , Tavasci Francesca
Published: September 2023

Biphasic stainless steels provide an excellent combination of mechanical and corrosion properties. The occurrence of ferrite spinodal decomposition during processing and heat treatment can induce a dramatic drop in impact energy. In this paper, a forged rod of 480 mm diameter made of 2507 biphasic stainless steel was studied. The spinodal decomposition phenomenon upon aging at 475 °C (748 K) was investigated by macro- and micro-hardness tests on the constituent phases and by Charpy impact tests. Then, the influence of the microstructural constituents and their morphology on the crack path was studied by optical microscopy, noting possible correlations with the impact energy. Successively, the fracture surfaces of selected specimens were analyzed by a scanning electron microscope (SEM). Finally, reversion heat treatments at 550 °C (823 K) and 600 °C (873 K) were investigated to evaluate the possibility of recovering the detrimental effects of the α′ embrittlement. According to the literature, this procedure works well with some biphasic steels, but these steels are characterized by a chromium content lower than that of 2507 grade steel. Regarding the 2507 grade steel studied in this work, complete reversion was obtained by solution-annealing treatment, while reversion heat treatments at both 600 °C (873 K) and 550 °C (823 K) allowed only a partial recovery.
Short Fluoroalkanes Suppress a Thermally-Induced Phase Transition in a Layered Organic Crystal
Authors: Marjo Christopher E. , Rich Anne M. , Bhadbhade Mohan M. , Bhattacharyya Saroj , Yin Songyan , Miskovic David M. , Aldilla Vina R. , Kumar Naresh
Published: September 2023

Ensuring a consistent crystal structure over a wide temperature range can be desirable behaviour in organic devices. This study investigates a layered crystal system formed by hydrogen-bonded chloro-s-triazine rings functionalised with alkyl or fluoroalkyl chains between the layers. When substituted with N-propyl groups (C3), the crystal undergoes a thermally-induced phase transition where the chains are ordered and bent below 170 K and disordered and extended above 175 K. Replacement with fluorinated N-propyl chains (C3-F) produces the same layered crystal but successfully suppresses the phase transition. The hydrocarbon and fluorocarbon analogues were found to be incompatible and unable to form co-crystals from solution or with mechanical mixing. Both effects were ascribed to more attractive C-F…F-C and C-H…F-C interactions in the fluorinated analogue. Long perfluoroalkanes are well known for controlling assembly in the solid state, but this study suggests that short-chain fluoroalkanes can exert strong control over the assembly and stability of an organic crystal.
Influence of Polymeric Blends on Bioceramics of Hydroxyapatite
Authors: Gomes Eduardo da Silva , Lima Antônia Millena de Oliveira , Gavinho Sílvia Rodrigues , Graça Manuel Pedro Fernandes , Devesa Susana , Macêdo Ana Angélica Mathias
Published: September 2023

Bioceramics are used to repair, rebuild, and replace parts of the human body, e.g., bones, joints and teeth, in the form of powder, coatings or prostheses. The synthetic hydroxyapatite [Ca10(PO4)6(OH)2 (HAP)] based on calcium phosphate has been widely used in the medical and dental areas due to the chemical similarity with the inorganic component of human bone tissue. In this work, hydroxyapatite nanocrystalline powders were synthesized by the solid-state reaction method and sintered with a galactomannan and chitosan blend. The bioceramics studied were prepared from 70%, 80% and 90% of hydroxyapatite with 30%, 20% and 10% of galactomannan and chitosan blends, respectively. The influence of the blend content on the bioceramics was investigated through structural, vibrational, thermal, morphological and dielectric characterizations. It was observed that the increase in the blend percentage promoted an increase in the grain size, which was followed by a decrease in the density and hardness of the samples. The sample with a higher amount of polymeric blend also presented a higher dielectric constant and higher losses.
Education, Employment, and Financial Outcomes in Adolescent and Young Adult Cancer Survivors—A Systematic Review
Authors: Altherr Aurelia , Bolliger Céline , Kaufmann Michaela , Dyntar Daniela , Scheinemann Katrin , Michel Gisela , Mader Luzius , Roser Katharina
Published: September 2023

Adolescents and young adults (AYAs) with cancer face unique challenges. We aimed to describe (i) education, employment, and financial outcomes and (ii) determinants for adverse outcomes in AYA cancer survivors. We performed a systematic literature search. We included original research articles on AYA (15–39 years of age) cancer survivors (≥2 years after diagnosis) and our outcomes of interest. We narratively synthesized the results of the included articles. We included 35 articles (24 quantitative and 11 qualitative studies). Patients in education had to interrupt their education during cancer treatment, and re-entry after treatment was challenging. After treatment, most survivors were employed but started their employment at an older age than the general population. Overall, no disadvantages in income were found. Survivors reported more absent workdays than comparisons. We identified chemotherapy, radiotherapy, late effects or health problems, female sex, migration background, and lower education associated with adverse outcomes. Although most AYA cancer survivors were able to re-enter education and employment, they reported difficulties with re-entry and delays in their employment pathway. To facilitate successful re-entry, age-tailored support services should be developed and implemented.
Usefulness of T2-Weighted Images with Deep-Learning-Based Reconstruction in Nasal Cartilage
Authors: Gao Yufan , Liu Weiyin (Vivian) , Li Liang , Liu Changsheng , Zha Yunfei
Published: September 2023

Objective: This study aims to evaluate the feasibility of visualizing nasal cartilage using deep-learning-based reconstruction (DLR) fast spin-echo (FSE) imaging in comparison to three-dimensional fast spoiled gradient-echo (3D FSPGR) images. Materials and Methods: This retrospective study included 190 set images of 38 participants, including axial T1- and T2-weighted FSE images using DLR (T1WIDL and T2WIDL, belong to FSEDL) and without using DLR (T1WIO and T2WIO, belong to FSEO) and 3D FSPGR images. Subjective evaluation (overall image quality, noise, contrast, artifacts, and identification of anatomical structures) was independently conducted by two radiologists. Objective evaluation including signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) was conducted using manual region-of-interest (ROI)-based analysis. Coefficient of variation (CV) and Bland–Altman plots were used to demonstrate the intra-rater repeatability of measurements for cartilage thickness on five different images. Results: Both qualitative and quantitative results confirmed superior FSEDL to 3D FSPGR images (both p < 0.05), improving the diagnosis confidence of the observers. Lower lateral cartilage (LLC), upper lateral cartilage (ULC), and septal cartilage (SP) were relatively well delineated on the T2WIDL, while 3D FSPGR showed poorly on the septal cartilage. For the repeatability of cartilage thickness measurements, T2WIDL showed the highest intra-observer (%CV = 8.7% for SP, 9.5% for ULC, and 9.7% for LLC) agreements. In addition, the acquisition time for T1WIDL and T2WIDL was respectively reduced by 14.2% to 29% compared to 3D FSPGR (both p < 0.05). Conclusions: Two-dimensional equivalent-thin-slice T1- and T2-weighted images using DLR showed better image quality and shorter scan time than 3D FSPGR and conventional construction images in nasal cartilages. The anatomical details were preserved without losing clinical performance on diagnosis and prognosis, especially for pre-rhinoplasty planning.
Predicting Outcome after Percutaneous Ablation for Early-Stage Hepatocellular Carcinoma Using Various Imaging Modalities
Authors: Shimizu Ryo , Ida Yoshiyuki , Kitano Masayuki
Published: September 2023

Percutaneous ablation is a low-invasive, repeatable, and curative local treatment that is now recommended for early-stage hepatocellular carcinoma (HCC) that is not suitable for surgical resection. Poorly differentiated HCC has high-grade malignancy potential. Microvascular invasion is frequently seen, even in tumors smaller than 3 cm in diameter, and prognosis is poor after percutaneous ablation. Biopsy has a high risk of complications such as bleeding and dissemination; therefore, it has limitations in determining HCC tumor malignancy prior to treatment. Advances in diagnostic imaging have enabled non-invasive diagnosis of tumor malignancy. We describe the usefulness of ultrasonography, computed tomography, magnetic resonance imaging, and 18F-fluorodeoxyglucose positron emission tomography for predicting outcome after percutaneous ablation for HCC.
An Autonomous Soaring for Small Drones Using the Extended Kalman Filter Thermal Updraft Center Prediction Method Based on Ordinary Least Squares
Authors: An Weigang , Lin Tianyu , Zhang Peng
Published: September 2023

Many birds in the natural world are capable of engaging in sustained soaring within thermal updrafts for extended periods without flapping their wings. Autonomous soaring has the potential to greatly improve both the range and endurance of small drones. In this paper, the extended Kalman filter (EKF) thermal updraft center prediction method based on ordinary least squares (OLS) is proposed to develop the autonomous soaring system for small drones, and an adaptive step size update strategy is incorporated into the EKF. The proposed method is compared with EKF thermal updraft prediction methods through simulated experiments. The results indicate that the proposed prediction method has low computational complexity and fast convergence speed and performs more stably in weak thermal updrafts. The above advantages stem from the OLS providing an approximate distribution of the thermal updraft around the drone for the EKF. This empowers the EKF algorithm with ample information to dynamically update the thermal updraft center in real time. The adaptive step size update strategy further accelerates the convergence speed of this process. In addition, flight experiments were conducted on the Talon fixed-wing drone platform to test the autonomous soaring system. During the flight experiment, the drone successfully engaged in static soaring within thermal updrafts, effectively hovering and gaining energy. Throughout the approximately 40 min flight duration, the drone only utilized its propulsion for about 8 min. This demonstrated the effectiveness of the autonomous soaring system using the EKF thermal updraft center prediction method based on OLS. Finally, by analyzing and discussing the differences between the simulation experiment results and the flight experiment results, some improvement strategies for the current work are proposed.
Religious Doubts and the Problem with Religious Pressures for Christian Students
Authors: Walker Andrea C. , Lang Andrew S. I. D. , Munoz Ricky
Published: September 2023

Educational literature has underscored the importance of higher education attending to students’ religious development. For Christian students, environment plays a role. Recent Christian religious development literature focusing on environmental predictors of growth found that higher religious pressures, assumed to be a controller according to Self-Determination Theory, predicted religious growth for students. The current study examines this finding by considering the influence of religious pressures along with normative experiences of religious doubt on spiritual/religious development variables of relatedness and self-mastery. A web-based survey procured responses from a large sample of students from both Christian and public/secular institutions. Controlling for sex and institution, multiple linear regression modeling was used to develop a model hypothesizing that when religious doubts are high, greater pressure would result in lower levels of religious development. The model was supported for spiritual/religious self-mastery but not for relatedness. Students’ quotes were presented to illustrate the findings that emerged from the data analysis. Results clarify the deleterious role of religious pressures for Christians at certain developmental and situational milestones who are also simultaneously experiencing religious doubt and/or questioning their beliefs about God. Given past findings about the uncomfortable and unsatisfying, albeit necessary, role of engaging in some religious doubt and exploration, religious pressures can sabotage effective adaptation. The results underscore the importance of higher education administrators allowing space and support for religious questioning and doubt. Moreover, administrators in Christian universities should help facilitate the honest expression of their students’ doubts and questions and the minimization of environmental religious pressures.
Evidence-Based Design of a Teacher Professional Development Program for Differentiated Instruction: A Whole-Task Approach
Authors: Meutstege Kyra , Van Geel Marieke , Visscher Adrie
Published: September 2023

Teachers are urged to provide differentiated instruction (DI), that is, deliberately adapting instruction to the learning needs of all students. DI can positively affect students’ academic achievement and their social and emotional development, as well as foster teacher job satisfaction. However, international research, as well as research in the Dutch context, has shown that teachers feel unprepared to provide DI. Hence, the development of teacher professional development (TPD) programs is necessary. In the current paper, the design of a TPD intervention to support DI is presented, in which the content and design approach were deliberately chosen. The intervention content was based on an analysis of the skills and knowledge expert teachers use when providing DI. The design of the intervention was based on the whole-task approach from the 4C/ID model to promote the transfer of learning, among other things. Based on the experiences of the teachers participating in the training pilot (n = 4), we provide our recommendations for future TPD for DI. The next step will be to study the effects of this TPD program on a larger scale to obtain insight into what design characteristics do or do not work, which can be used to further improve this TPD intervention.
Large-Signal Stability Analysis for Islanded DC Microgrids with n+1 Parallel Energy-Storage Converters
Authors: Liu Xinbo , Zhang Yiran , Suo Yongbing , Song Xiaotong , Zhou Jinghua
Published: September 2023

In islanded DC microgrids, the negative impedance characteristics of constant power loads (CPLs) usually introduce instability influences; on the contrary, hybrid energy-storage systems (HESSs) constituted of batteries and supercapacitors (SCs) have stabilization advantages. To guarantee the large-signal stability of islanded DC microgrids with n+1 parallel energy-storage converters, an equivalent model is first constructed based on the control strategies of the converters. Then, according to the mixed potential function theory, a large-signal stability criterion, considering powers, inductors, capacitors, the DC bus voltage, the equivalent internal resistances of batteries, the proportional parameters of the inner current loop of n battery DC–DC converters, the proportional parameter of the outer power control loop of the SC DC–DC converter, and the proportional parameter of the inner current loop of the CPLs, is derived. Furthermore, the proposed large-signal stability criterion is optimized via the use of droop control for n battery converters, and coefficients related to the droop coefficients are also taken into account. These involved control parameters reveal the process of regulating the HESS and CPLs instead of ideal modeling and significantly reduce the conservatism of the criterion to some extent. In addition, on the basis of the large-signal stability criterion presented herein, the maximum CPL power that the islanded DC microgrids can stably support is obtained. Finally, simulation and experimental results verify the validity of the provided large-signal-stability criterion. The given procedure of analyzing large-signal stability is more consistent with planning and operating actual DC microgrids.
Few-Shot Object Detection with Local Feature Enhancement and Feature Interrelation
Authors: Lai Hefeng , Zhang Peng
Published: September 2023

Few-shot object detection (FSOD) aims at designing models that can accurately detect targets of novel classes in a scarce data regime. Existing research has improved detection performance with meta-learning-based models. However, existing methods continue to exhibit certain imperfections: (1) Only the interacting global features of query and support images lead to ignoring local critical features in the imprecise localization of objects from new categories. (2) Convolutional neural networks (CNNs) encounter difficulty in learning diverse pose features from exceedingly limited labeled samples of unseen classes. (3) Local context information is not fully utilized in a global attention mechanism, which means the attention modules need to be improved. As a result, the detection performance of novel-class objects is compromised. To overcome these challenges, a few-shot object detection network is proposed with a local feature enhancement module and an intrinsic feature transformation module. In this paper, a local feature enhancement module (LFEM) is designed to raise the importance of intrinsic features of the novel-class samples. In addition, an Intrinsic Feature Transform Module (IFTM) is explored to enhance the feature representation of novel-class samples, which enriches the feature space of novel classes. Finally, a more effective cross-attention module, called Global Cross-Attention Network (GCAN), which fully aggregates local and global context information between query and support images, is proposed in this paper. The crucial features of novel-class objects are extracted effectively by our model before the feature fusion between query images and support images. Our proposed method increases, on average, the detection performance by 0.93 (nAP) in comparison with previous models on the PASCAL VOC FSOD benchmark dataset. Extensive experiments demonstrate the effectiveness of our modules under various experimental settings.
A Fast Facet-Based SAR Imaging Model and Target Detection Based on YOLOv5 with CBAM and Another Detection Head
Authors: Wang Qingkuan , Sheng Jing , Tong Chuangming , Wang Zhaolong , Song Tao , Wang Mengdi , Wang Tong
Published: September 2023

Synthetic Aperture Radar (SAR) image target detection is of great significance in civil surveillance and military reconnaissance. However, there are few publicly released SAR image datasets of typical non-cooperative targets. Aiming to solve this problem, a fast facet-based SAR imaging model is proposed to simulate the SAR images of non-cooperative aircraft targets under different conditions. Combining the iterative physical optics and the Kirchhoff approximation, the scattering coefficient of each facet on the target and rough surface can be obtained. Then, the radar echo signal of an aircraft target above a rough surface environment can be generated, and the SAR images can be simulated under different conditions. Finally, through the simulation experiments, a dataset of typical non-cooperative targets can be established. Combining the YOLOv5 network with the convolutional block attention module (CBAM) and another detection head, a SAR image target detection model based on the established dataset is realized. Compared with other YOLO series detectors, the simulation results show a significant improvement in precision. Moreover, the automatic target recognition system presented in this paper can provide a reference for the detection and recognition of non-cooperative aircraft targets and has great practical application in situational awareness of battlefield conditions.
A 5G Coverage Calculation Optimization Algorithm Based on Multifrequency Collaboration
Authors: Li Xiao , Guo Han , Xie Weiliang , Ding Xue
Published: September 2023

The fifth–generation (5G) network is developing rapidly. The network coverage directly influences the quality of service (QoS) of vertical industries. Coverage capability is a crucial and indispensable indicator when evaluating the performance of a network. However, the results of the current algorithm fall short in terms of accuracy. To restore the current status of 5G network coverage more realistically, in this study, we design a new optimization algorithm for coverage calculation based on the traditional coverage algorithm combined with fourth–generation (4G) coverage reference signal receiving power (RSRP) in management report (MR) and adopt a multisystem collaborative analysis method. The algorithm corrects the coverage results and restores the true value of 5G coverage. Based on this, we provide a practical analysis of the largest standalone (SA) commercial network in the world, which confirms the viability of the algorithm. Both theoretical and practical analyses show that the algorithm can effectively detect hidden weak coverage areas, providing a further reference for future 5G construction and improving the 5G user experience. The proposed approach can be broadly generalized and applied to multifrequency, multioperator, or even sixth–generation (6G) networks.
“I BROKE FREE” Youth Activism and the Search for Rights for Children Born of War in Bosnia
Authors: Ellis Burcu Akan
Published: September 2023

The rise in recognition of children’s agency—that is, their status as inalienable right-bearing actors—has been a welcome change in international organizations, albeit often through a set of media activities that depict children variously as victims or beneficiaries of moral leadership. Typically, a handful of children/youth affected directly by a particular tragedy become the recognizable faces of identified human rights abuses. This research explores media representation of children born of war in Bosnia, “invisible” children who only recently were legally categorized as victims of war. As children who were born of wartime rape, the lives of select young activists have been documented through movies and media interviews since their childhood. This paper explores the costs of such disclosure and performativity, and sacrifices that young activists make to expose their “truth” to gain recognition of their attendant rights. It ultimately highlights the tension between the search for the rights of affected children and the dilemmas inherent in the actions of the few youth activists who publicly embrace the conditions of their birth to bring voice to others.
Rediscovering Cova de la Sarsa (València, Spain): A Multidisciplinary Approach to One of the Key Early Neolithic Sites in the Western Mediterranean
Authors: Salazar-García Domingo C. , García-Borja Pablo , Talamo Sahra , Richards Michael P.
Published: September 2023

Cova de la Sarsa (València, Spain) is one of the most important Neolithic impressed ware culture archaeological sites in the Western Mediterranean. It has been widely referenced since it was excavated in the 1920s, due partly to the relatively early excavation and publication of the site, and partly to the qualitative and quantitative importance of its archaeological remains. Unfortunately, as it was an older excavation and lacked present-day rigorous methodological approaches, this important site has been somewhat relegated to the background in the reviews about the Neolithic at the end of the 20th century. However, during the last few years, both the site itself and its archaeological remains have been the object of new studies that hopefully will return the site to the forefront of discussions about the Mediterranean Neolithic. We here present the most relevant results of the research carried out by our group (i.e., pottery study, radiocarbon dating, and isotope analysis), and contextualize them within the dense research history of the cave and the studies carried out by other colleagues with the purpose of revisiting its materials and increasing the knowledge available from the site. Radiocarbon dates on human remains show that the cave was used during prehistoric times as a funerary space longer than expected, and also sporadically afterwards. The characterization of the pottery assemblage concludes that most materials belong to the Early Neolithic. Isotopic analysis portrays an overall similar diet based on terrestrial C3 resources throughout prehistoric times, with a possible varied dietary protein input between individuals during the Early Neolithic.
Analyzing Indo-European Language Similarities Using Document Vectors
Authors: Schrader Samuel R. , Gultepe Eren
Published: September 2023

The evaluation of similarities between natural languages often relies on prior knowledge of the languages being studied. We describe three methods for building phylogenetic trees and clustering languages without the use of language-specific information. The input to our methods is a set of document vectors trained on a corpus of parallel translations of the Bible into 22 Indo-European languages, representing 4 language families: Indo-Iranian, Slavic, Germanic, and Romance. This text corpus consists of a set of 532,092 Bible verses, with 24,186 identical verses translated into each language. The methods are (A) hierarchical clustering using distance between language vector centroids, (B) hierarchical clustering using a network-derived distance measure, and (C) Deep Embedded Clustering (DEC) of language vectors. We evaluate our methods using a ground-truth tree and language families derived from said tree. All three achieve clustering F-scores above 0.9 on the Indo-Iranian and Slavic families; most confusion is between the Germanic and Romance families. The mean F-scores across all families are 0.864 (centroid clustering), 0.953 (network partitioning), and 0.763 (DEC). This shows that document vectors can be used to capture and compare linguistic features of multilingual texts, and thus could help extend language similarity and other translation studies research.
Multimodal Therapy with Consolidating Haploidentical Stem Cell Transplantation and Dinutuximab Beta for Patients with High-Risk Neuroblastoma and Central Nervous System Relapse
Authors: Flaadt Tim , Ebinger Martin , Schreiber Malin , Ladenstein Ruth L. , Simon Thorsten , Lode Holger N. , Hero Barbara , Schuhmann Martin U. , Schäfer Jürgen , Paulsen Frank , Timmermann Beate , Eggert Angelika , Lang Peter
Published: September 2023

Despite highly intensive multimodality treatment regimens, the prognosis of patients with high-risk neuroblastoma (HRNB) and central nervous system (CNS) relapse remains poor. We retrospectively reviewed data from 13 patients with HRNB and CNS relapse who received multimodal therapy with consolidating haploidentical stem cell transplantation (haplo-SCT) followed by dinutuximab beta ± subcutaneous interleukin-2 (scIL-2). Following individual relapse treatment, patients aged 1−21 years underwent haplo-SCT with T/B-cell-depleted grafts followed by dinutuximab beta 20 mg/m2/day × 5 days for 5–6 cycles. If a response was demonstrated after cycle 5 or 6, patients received up to nine treatment cycles. After haplo-SCT, eight patients had a complete response, four had a partial response, and one had a stable disease. All 13 patients received ≥3 cycles of immunotherapy. At the end of the follow-up, 9/13 patients (66.7%) demonstrated complete response. As of July 2023, all nine patients remain disease-free, with a median follow-up time of 5.1 years since relapse. Estimated 5-year event-free and overall survival rates were 55.5% and 65.27%, respectively. Dinutuximab beta ± scIL-2 following haplo-SCT is a promising treatment option with a generally well-tolerated safety profile for patients with HRNB and CNS relapse.
Dialysis Patients Respond Adequately to Influenza Vaccination Irrespective of Dialysis Modality and Chronic Inflammation
Authors: Pleros Christos , Adamidis Konstantinos , Kantartzi Konstantia , Griveas Ioannis , Baltsavia Ismini , Moustakas Aristides , Kalliaropoulos Antonios , Fraggedaki Evaggelia , Petra Christina , Damianakis Nikolaos , Mentis Andreas , Drosataki Eleni , Petrakis Ioannis , Passadakis Ploumis , Panagopoulos Periklis , Stylianou Kostas , Panagoutsos Stylianos
Published: September 2023

(1) Background: Chronic inflammation and suboptimal immune responses to vaccinations are considered to be aspects of immune dysregulation in patients that are undergoing dialysis. The present study aimed to evaluate immune responses in hemodialysis (HD) and online hemodiafiltration (OL-HDF) patients to a seasonal inactivated quadrivalent influenza vaccine (IQIV). (2) Methods: We enrolled 172 chronic dialysis patients (87 on HD and 85 on OL-HDF) and 18 control subjects without chronic kidney disease in a prospective, cross-sectional cohort study. Participants were vaccinated with a seasonal IQIV, and antibody titers using the hemagglutination inhibition (HI) assay were determined before vaccination (month 0) and 1, 3, and 6 months thereafter. Demographics and inflammatory markers (CRP, IL-6, IL-1β) were recorded at month 0. The primary endpoints were the rates of seroresponse (SR), defined as a four-fold increase in the HI titer, and seroprotection (SP), defined as HI titer ≥ 1/40 throughout the study period. Statistical analyses were conducted in R (version 3.6.3) statistical software. The differences between groups were analyzed using chi-square and t-test analyses for dichotomous and continuous variables, respectively. To identify independent determinants of SR and SP, generalized linear models were built with response or protection per virus strain as the dependent variable and group, age, sex, time (month 0, 1, 3, 6), diabetes, IL-6, dialysis vintage, HD access, and HDF volume as independent explanatory variables. (3) Results: SR and SP rates were similar between control subjects, and dialysis patients were not affected by dialysis modality. SP rates were high (> 70%) at the beginning of the study and practically reached 100% after vaccination in all study groups. These results applied to all four virus strains that were included in the IQIV. IL-6 levels significantly differed between study groups, with HD patients displaying the highest values, but this did not affect SP rates. (4) Conclusions: Dialysis patients respond to influenza immunization adequately and similarly to the general population. Thus, annual vaccination policies should be encouraged in dialysis units. OL-HDF reduces chronic inflammation; however, this has no impact on SR rates.
Cochleo-Vestibular Disorders in Herpes Zoster Oticus: A Literature Review and a Case of Bilateral Vestibular Hypofunction in Unilateral HZO
Authors: Teggi Roberto , Del Poggio Anna , Cangiano Iacopo , Nobile Alessandro , Gatti Omar , Bussi Mario
Published: September 2023

The varicella-zoster virus (VZV), a member of the Herpesviridae family, causes both the initial varicella infection and subsequent zoster episodes. Disorders of the eighth cranial nerve are common in people with herpes zoster oticus (HZO). We performed a review of the literature on different databases including PubMed and SCOPUS, focusing on cochlear and vestibular symptoms; 38 studies were considered in our review. A high percentage of cases of HZO provokes cochlear and vestibular symptoms, hearing loss and vertigo, whose onset is normally preceded by vesicles on the external ear. It is still under debate if the sites of damage are the inferior/superior vestibular nerves and cochlear nerves or a direct localization of the infection in the inner ear. The involvement of other contiguous cranial nerves has also been reported in a few cases. We report the case of a patient with single-side HZO presenting clinical manifestations of cochleo-vestibular damage without neurological and meningeal signs; after 15 days, the patient developed a new episode of vertigo with clinical findings of acute contralateral vestibular loss. To our knowledge, only three other such cases have been published. An autoimmune etiology may be considered to explain these findings.
First Clinical Case Report of a Xenograft–Allograft Combination for Alveolar Ridge Augmentation Using a Bovine Bone Substitute Material with Hyaluronate (Cerabone® Plus) Combined with Allogeneic Bone Granules (Maxgraft®)
Authors: Kloss Frank R. , Kämmerer Peer W. , Kloss-Brandstätter Anita
Published: September 2023

Background: A patient had lost the first left maxillary incisor in the esthetic zone. Methods: The defect in the alveolar ridge was reconstructed for an implant-supported restoration using a new xenogeneic bone substitute containing hyaluronate, which was used in combination with allogeneic bone granules. Results: After three years of follow-up, the dental implant was stable and showed no signs of infection. Conclusions: This is the first case report with a long-term follow-up time of three years of a successful clinical application of a xenograft–allograft combination (cerabone® plus combined with maxgraft®) for alveolar ridge augmentation before dental implantation. Cerabone® plus offers volume stability, provides reliable and efficient structural support of the oral soft tissues in the augmented region (particularly crucial in the aesthetic zone), and preserves the alveolar ridge shape.
Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic Dysfunction-Associated Steatohepatitis: The Patient and Physician Perspective
Authors: Eskridge Wayne , Cryer Donna R. , Schattenberg Jörn M. , Gastaldelli Amalia , Malhi Harmeet , Allen Alina M. , Noureddin Mazen , Sanyal Arun J.
Published: September 2023

Diagnosing and managing metabolic dysfunction-associated steatotic liver disease (MASLD) remains a major challenge in primary care due to lack of agreement on diagnostic tools, difficulty in identifying symptoms and determining their cause, absence of approved pharmacological treatments, and limited awareness of the disease. However, prompt diagnosis and management are critical to preventing MASLD from progressing to more severe forms of liver disease. This highlights the need to raise awareness and improve understanding of MASLD among both patients and physicians. The patient perspective is invaluable to advancing our knowledge of this disease and how to manage it, as their perspectives have led to the growing recognition that patients experience subtle symptoms and that patient-reported outcomes should be incorporated into drug development. This review and expert opinion examine MASLD and metabolic dysfunction-associated steatohepatitis from the patient and physician perspective from pre-diagnosis to diagnosis and early care, through to progression to advanced liver damage. Specifically, the paper dives into the issues patients and physicians experience, and, in turn, what is required to improve diagnosis and management, including tips and tools to empower patients and physicians dealing with MASLD.