bluuebunny/crossref_metadata_2025 huggingface dataset:
KORELASI ANTARA RASIO NEUTROFIL/LIMFOSIT DENGAN KADAR C-REACTIVE PROTEIN PADA PENDERITA TUBERKULOSIS PARU
Authors: Aufani Destia , Azzahra Larasabella , Supriyanto Supriyanto , Fatayati Imma , Nuswantoro Ari
Published: October 2024

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and can persist in all parts of the body. Laboratory tests used to determine the level of inflammation in TB sufferers include the neutrophil/lymphocyte ratio (RNL) and C-reactive protein (CRP) levels. The RNL value is the ratio of the absolute number of neutrophils and the absolute number of lymphocytes, while CRP is an acute phase protein produced in the liver, and its levels increase within 6 hours in acute inflammation. The aim of this study was to determine the relationship between RNL and CRP in pulmonary TB patients. This research was a descriptive study with a cross-sectional design carried out from April to June 2021 at the Lung Health Services Integrated Service Unit, West Kalimantan Province. The number of samples was determined using a purposive sampling technique, with the criteria being newly diagnosed TB patients who had positive BTA, positive TCM and positive X-ray results, resulting in 48 samples. CRP levels were measured using the latex agglutination method, while the number of neutrophils and lymphocytes used the impedance method. Analysis was carried out using the Shapiro-Wilk normality test and Kendall's tau b correlation test. Statistical analysis using the Kendall's tau b correlation test obtained a significant value of 0.000 (<0.05), which means there was a relationship between RNL and CRP levels in pulmonary TB patients with a correlation coefficient of 0.489, which means the relationship between the two variables is enough.
ASSESSING INDIVIDUAL PERCEPTION IN UTILIZATION OF NON-COMMUNICABLE DISEASES POST (NCDS POST) USING A HEALTH BELIEF MODEL (HBM) APPROACH
Authors: Faatih Mukhlissul , Siregar Riswal Hanafi , Su'udi Amir , Despitasari Mieska , Wirasmi Sundari , Anggraini Anggita Bunga , Syachroni Syachroni , Marsini Rani , Latifa Rivana
Published: October 2024

Fasilitas Posbindu PTM telah menjadi komponen penting dalam kebijakan kesehatan. Penelitian mengungkapkan bahwa hal tersebut belum dimanfaatkan secara optimal. Penelitian ini bertujuan untuk mengetahui hubungan persepsi peserta dengan pemanfaatan Posbindu PTM. Penelitian menggunakan desain cross-sectional dan dilakukan di lima provinsi di Indonesia. Pengumpulan data dilakukan dengan wawancara dan pengisian kuesioner pada bulan Agustus-Oktober 2021. Analisis dilakukan dengan uji statistik beda mean. Kami melibatkan 420 peserta dalam penelitian ini. Hasil penelitian menunjukkan sebagian besar peserta rentan terhadap PTM (52,6%). Peserta menilai seseorang yang menderita PTM memberikan dampak yang serius (53.6%), mengelola dan memeriksa kesehatan di Posbindu PTM mempunyai manfaat dalam mencegah PTM (62.6%), seseorang yang menderita PTM menimbulkan dampak yang serius (71.4%), melakukan kegiatan yang bermanfaat untuk menjaga kesehatan secara rutin khususnya pencegahan PTM (69,0%), mempunyai kemampuan, pengendalian, dan mempunyai cara untuk mencegah PTM (65,2%). Hasil uji beda rata-rata menunjukkan bahwa rata-rata rangking seluruh penilaian persepsi HBM peserta yang aktif mengikuti kegiatan Posbindu PTM lebih tinggi dibandingkan peserta yang kurang aktif (p<0,05). Pemanfaatan aktif Posbindu PTM mempunyai hubungan dengan persepsi peserta khususnya terhadap tingkat keparahan suatu penyakit, kerentanan seseorang terhadap penyakit, manfaat mengetahui risiko kesehatan, hambatan dalam melakukan pemeriksaan kesehatan, petunjuk tindakan, dan efikasi diri pasien terhadap penyakitnya.
HUBUNGAN KRONOTIPE DENGAN DERAJAT NYERI DISMENORE PADA REMAJA PUTRI
Authors: Ardina Safira Cindra , Widyaningsih Vitri , Lestari Anik
Published: October 2024

Dysmenorrhea is one of the most common menstrual disorders in young women. The prevalence of dysmenorrhea in adolescent girls in Indonesia ranges from 16.8-81%. Girls with dysmenorrhea symptoms have a higher risk of decreased activity, experiencing hip strain, back pain, headaches, and fatigue. In school children, it can interfere with learning activities and concentration, causing academic decline. Dysmenorrhea is influenced by several factors from daily activities and habits. Activity can affect a person's sleep and wake schedule. The difference in sleep and activity schedules of each person is known as kronotipe. The study aimed to determine the relationship between kronotipe and the degree of dysmenorrhea pain in adolescent girls at SMKN 1 Doko Blitar. The research was conducted in August-September 2021. The population of the study was 60 students of SMK 1 Doko in Blitar district aged 15-18 years old, non-smoking, and who want to join this study. The research plan is a cross-sectional study using MEQ-SA (Morningness-Eveningness Questionnaire Self-Assessment Version), and the dysmenorrhea questionnaire. Data analysis uses the chi-square test. The result of chi-square test showed a significant correlation between the kronotipe with the degree of dysmenorrhea pain (p-value= 0,000). There is a significant relationship between chronotype and the degree of dysmenorrhea pain. Adolescent girls need to set a regular sleep schedule to have an appropriate chronotype to reduce dysmenorrhea pain during menstruation.
ASPERGILLOMA PADA TUBERKULOSIS PARU: LITERATURE REVIEW
Authors: Arianto Wily , Lasmaria Rohani
Published: October 2024

Indonesia ranking among the top six countries with the highest TB burden. In the aftermath of pulmonary TB, fungal infections, particularly those caused by Aspergillus species, have emerged as a notable complication. The predominant species, Aspergillus fumigatus, is responsible for a spectrum of conditions ranging from invasive to noninvasive aspergillosis. This literature review aims to provide an exhaustive analysis of post-TB pulmonary aspergilloma, a clinical condition characterized by the growth of Aspergillus fungal balls within pre-existing lung cavities. Utilizing databases such as PubMed, Science Direct, EBSCO, Emerald, Scopus, and Google Scholar, and employing keywords such as "tuberculosis," "aspergillus," "aspergilloma," and "pulmonary," we meticulously applied the PICO framework and the CRAAP (Currency, Relevance, Authority, Accuracy, and Purpose) criteria to select 20 pertinent articles. The findings indicate that pulmonary aspergilloma manifests in approximately 11% to 17% of individuals post-TB treatment, presenting a clinical spectrum from asymptomatic to severe, life-threatening hemoptysis. Classification into simple and complex aspergilloma is based on specific clinical and radiological criteria. Diagnosis is contingent upon the identification of clinical symptoms, assessment of risk factors, and the corroboration of Aspergillus infection through radiological (chest X-ray and CT scan) and serological or microbiological evidence. Management of pulmonary aspergilloma entails non-operative and operative strategies, with surgical intervention being the definitive treatment, especially in cases of recurrent or massive hemoptysis. The review underscores the persistent challenge of TB in Indonesia, exacerbated by secondary fungal infections such as aspergillosis among pulmonary TB survivors. Aspergillus fumigatus is identified as the primary fungal pathogen, leading to pulmonary aspergilloma.
EFEKTIVITAS EDUKASI ANTENATAL TERHADAP KETAKUTAN DAN EFIKASI DIRI PERSALINAN PADA PRIMIPARA: SYSTEMATIC REVIEW
Authors: Syamsuriati Syamsuriati , Rachmawati Imami Nur , Kurniawati Wiwit
Published: October 2024

Fear of giving birth due to lack of knowledge causes a decrease in primigravida mothers' confidence in their ability to undergo childbirth. Decreased self-efficacy in childbirth can cause birth complications such as prolonged labor, fatigue and weakness in the mother, which results in the mother's failure to undergo a natural birth. Antenatal education is an appropriate alternative to increase mothers' knowledge of the birth process. The aim of the research was to examine the effectiveness of antenatal education in reducing fear of childbirth and increasing childbirth self-efficacy in primiparous mothers. The structure of this research is a detailed analysis using the PRISMA flow diagram. Researchers applied the PICO method and searched for articles in English published between 2018 and 2023. Some of the databases used included Proquest, PUBMED, Sage Journal, Springer Link, Science Direct, EBSCO, Plos One and Taylor & Francis. Article quality assessment using JBI Critical Appraisal Tools for RCT. Seven articles were identified and analyzed, all articles used a Randomized Controlled Trial design. The research sample numbered 56 to 182, consisting of primiparas in the age range 18-32 years with a gestational age of <34 weeks and was conducted in Saudi Arabia, Turkey, Iran and China. From the literature search, in general it can be concluded that antenatal education provided to primiparous mothers is effective in reducing fear of childbirth and increasing self-efficacy in childbirth.
FAKTOR- FAKTOR YANG BERHUBUNGAN DENGAN KEBERADAAN JENTIK NYAMUK AEDES AEGYPTI
Authors: Susmaneli Herlina , Hidayati Ummi , Agnesia Yoana
Published: October 2024

The existence of Aedes aegypti larvae is evidence of the discovery of a population of Aedes aegypti mosquitoes that influence the occurrence of Dengue Hemorrhagic Fever. The larvae-free rate in Labuh Baru Timur Subdistrict was found to be 85%, which shows that it has not reached the national standard above or equal to 95%. The research aimed to determine the factors related to the presence of Aedes aegypti mosquito larvae in Labuh Baru Timur Subdistrict, the working area of ​​the Payung Sekaki Community Health Center, Pekanbaru City in 2023. This research method was quantitative using Observational Analytical with a cross-sectional design. The research was carried out in February - July 2023. The sampling technique was quota sampling of 100 heads of families. The data analysis used is univariate and bivariate. The results of the research showed that there was a relationship between knowledge, attitudes, eradicating mosquito nests, the color of the water reservoir, the location of the water reservoir, and the role of larva monitoring cadres (Jumantik) with the presence of Aedes aegypti mosquito larvae. It is hoped that the Payung Sekaki Community Health Center can provide KIE (Communication, Information, and Education) to the community regarding Dengue Hemorrhagic Fever (DHF), especially how to prevent the presence of Aedes aegypti mosquito larvae and the involvement of Jumantik Cadres is expected to be more active and effective.
KNOWLEDGE, BEHAVIOR, EXPOSURE, AND PERCEPTION OF STRESS, ANXIETY, AND DEPRESSION AMONG HEALTH CENTER WORKERS DURING COVID-19
Authors: Prihanti Gita Sekar , Illahika Anung Putri , Hasna Alifah , Natiq Ikmalun , Hadiningtyas Kartika Lintang , Furkan Muhammad , Wicaksono Trio Rizal , Drestania Zhenna Vinenzha Linda
Published: October 2024

Salah satu tantangan besar dalam pelayanan kesehatan yaitu krisis pandemi coronavirus disease (COVID-19). Petugas kesehatan di garis depan yang terlibat langsung dengan COVID-19 berisiko mengalami tekanan psikologis dan gejala kesehatan mental lebih tinggi ditambah dengan beban kerja yang semakin besar. Tujuan penelitian untuk mengetahui pengaruh pengetahuan, perilaku, paparan penyakit, persepsi risiko penyakit, dan ketakutan terhadap tingkat stres, kecemasan, dan depresi terkait COVID-19 pada petugas. Metode penelitian yang digunakan analitik observasional dengan desain cross sectional. Jumlah sampel 61 responden. Teknik sampling yang digunakan adalah total sampling. Sampel mengisi kuesioner dengan 61 item pertanyaan. Data dianalisis secara univariat untuk mengetahui karakteristik gambaran sampel, uji bivariat menggunakan uji chi-square untuk mengetahui hubungan antar variabel bebas terhadap variabel terikat, uji multivariat untuk mengetahui variabel bebas yang paling berpengaruh terhadap tingkat stres, kecemasan dan depresi. Hasil pada uji multivariat menunjukkan hubungan antara jenis kelamin perempuan dan tingkat stres (p = 0,018; OR = 14.026; CI = 1.564–125.741); terpapar terhadap tingkat stres (p = 0,012; OR = 16.319; CI = 1.848–144.095); dan persepsi risiko yang tinggi terhadap tingkat kecemasan (p = 0,003; OR = 25.288; CI = 2.953–216.543). Kesimpulan penelitian ini adalah terdapat faktor signifikan yang mempengaruhi  tingkat stres petugas pada masa COVID-19, yaitu jenis kelamin, paparan, persepsi risiko penyakit dan ketakutan mempengaruhi tingkat kecemasan petugas.
Comparative Statistical Analysis of Changes in Average Asking Prices for Housing in the Administrative Districts of Moscow
Authors: Chetverikov V. M. , Churbanov R. R.
Published: October 2024

The article presents the results of a comparative analysis of the residential real estate market in nine administrative districts of Moscow in 2016 and 2024. The paper focuses on the features of housing price formation and considers factors influencing pricing, including socio-economic conditions and transport infrastructure. The study outlines the role of housing construction and the investment attractiveness of various districts of the capital.The authors used official data from Russia's largest real estate technology service (CIAN) on asking prices for apartments for sale depending on their parameters. The article draws on such indicators as the local average price per square meter of the total area of dwellings and the number of offers of apartments for sale. It is shown that apartment prices in two administrative districts (AO) of Moscow have a stable growth trend in 2024, which was not observed in 2016. It is concluded that the real estate markets in the districts of Moscow in 2016 (exception for the Central AO) were strongly differentiated in price offers in 2024, and, therefore, it is incorrect to use the average price per square meter of Moscow residential real estate as a characteristic of housing quality in 2024.The article lists events that influenced changes in the Moscow residential real estate market without specifying the relative strength of their impact. According to the authors, each event had its causes, but their almost simultaneous appearance led to tension in the housing market for all participants.In conclusion, the significant impact of inflation and the restoration of residential premises (after renting) on the growth of residential property values and the potential for using housing as an investment object is emphasized
Results of Economic Tendency Surveys in Nowcasting GDP Growth
Authors: Kitrar L. A. , Rahmanov M. A. , Lipkind T. M.
Published: October 2024

The article proves the usefulness of including aggregate information from economic tendency surveys in the system of nowcasting of economic growth. The authors compare the efficiency of vector autoregressive models that include the economic sentiment indicator based on the results of Rosstat business activity and consumer expectations surveys, and the business climate indicator based on the results of the Bank of Russia enterprise monitoring.Statistical testing of time series of composite indicators and GDP volume index confirmed a significant correlation and causality between them, as well as the similarity of their cyclical profiles. Both indices pass cyclical turning points synchronously or ahead of the GDP volume index, their predictive capabilities are enhanced by the early availability of information. The capabilities of GDP growth nowcasting using survey information are assessed in three specifications of the vector autoregressive model with dummy variables. On the in-sample period, the model including two composite indicators and the GDP volume index demonstrates the highest accuracy.The proposed approach allows us to obtain flash estimates of GDP growth prospects that are significantly ahead of the official statistical information
Developing Statistical Thinking in Schoolchildren: From Theory to Practice
Authors: Eliseeva I. I. , Ponomarenko A. N. , Samoilova M. A.
Published: October 2024

Since 2022, the school course «Probability and Statistics» has been taught as a compulsory subject in all schools in Russia, and questions on it are included in the Unified State Exam. However, international experience in teaching the basics of statistics shows that this is not an easy task. It includes not only teaching students how to prove the theorems of mathematical statistics and explain the calculation of the median and variance, but also contributes to the development of statistical thinking in them – the ability to make decisions based on the analysis of empirical data. According to the authors, the statistical community cannot and should not replace teachers who promote the teaching of statistics at school, but it has the opportunity to make a significant contribution to this process.The article presents the experience of the All-Russian School competition on statistics «Trend», the All-Russian teacher competition for the best practices in teaching statistics «We train the best!», with the support of the territorial bodies of state statistics in St. Petersburg, Kirov and Rostov regions; master classes for hundreds of teachers teaching statistics in grades 7–11. In addition, the article presents plans for organizing a competition on civil statistics aimed at developing skills in working with statistical data, as well as teaching the basics of statistical analysis, the use of visualization tools, and the formation of citizenship through familiarity with objective statistical information
NARRATING THE WAR IN UKRAINIAN LITERATURE (2014-2023)
Authors:   Eberhard Karls University of Tübingen, Saikovska O.
Published: October 2024

The article is dedicated to the analysis of contemporary Ukrainian literature, that was written during the war (since 2014), with afocus on the texts, that reflect the Russian-Ukrainian war of different periods (till 2023). Ukraine, after more than 30 years of independence de-jure, is trying to get rid of the impact of the colonizer de-facto, which is a rather unique case to be studied within the postcolonial methodology. The war, as a cataclysm, influences Ukrainian society and the authors choose several strategies to talk about it: from presenting the war as a result of irresponsibility, separation and inevitability to providing the therapeutic effect that is demanded by Ukrainian society and after-the-victorynarrative (that is a very specific feature because of the still on-going war). The research is based on the works by Serhii Zhadan, Tamara Gorikha Zernya (Duda), Hanna Kostenko, Sofia Andrukhovych, Pavlo Korobchuk, Halyna Kruk, Ostap Slyvynskyi, Oleksandr Mykhed, Valerii Puzik. Keywords: trauma,memory,therapy,identity,contemporary literature, postcolonial studies, postmodern literature
Estudo de viabilidade econômica de sistemas fotovoltaicos residenciais no Brasil com a entrada da lei 14.300
Authors: Coelho Fabrício Pinto , Ferreira André Guimarães
Published: October 2024

A lei 14.300, também conhecida como Marco Legal da Micro e Minigeração de Energia, é um fruto do Projeto de Lei 5.829/2019. Essa legislação, que também é conhecida por "taxação do sol", trouxe alterações significativas para as regras da geração de energia solar no Brasil. Essa mudança passou a ser válida a partir de 7 de janeiro de 2023, ou seja, quem realizou a instalação de sistemas de energia solar até antes da data prevista, foi isento da cobrança de taxas até 2045. Apesar das vantagens do uso de instalações fotovoltaicas urbanas, essa nova lei pode impactar o custo e o tempo de retorno destas novas instalações. Uma nova análise de viabilidade precisa ser realizada, inserindo na composição de valores a Tarifa do Uso do Sistema de Distribuição (TUSD) que cobra a energia injetada na rede da concessionária que, posteriormente, será consumida no decorrer do tempo. Neste contexto, este trabalho propõe um estudo comparativo de viabilidade econômica da instalação de uma usina fotovoltaica residencial padrão em todo território nacional (26 capitais do estado brasileiro além do Distrito Federal), considerando os valores das tarifas das respectivas concessionárias com a modelagem de geração de energia e os seus impactos financeiros, a partir da implementação da Lei 14.300. Como principais resultados, foi observado que que quanto maiores os custos da tarifa cobrados pela concessionária, maior é o Valor Presente Líquido (VPL), predominando inclusive sobre a influência da radiação solar incidente ou da geração de energia fotovoltaica, das 27 localidades abordados pelo estudo.
Design Principles for a Higher Education Course Focusing on Lifelong Learning
Authors: Brodén Karin , Johansson John , Bergkvist Linda , Humble Niklas , Mozelius Peter
Published: October 2024

Lifelong learning for solving work assignments is essential for societal and personal development. Higher education is one natural part of lifelong learning and, therefore, needs to be re-focused from solely younger students to include professionals and their development goals. One problem related to giving a course for professionals is their struggle between work assignments and the course. Focusing on the added perspective of professionals for higher education, this study presents five design principles for courses for professionals. Design principles are guidelines based on experience and iterative development in higher education. The empirical data comes from a course in digitalisation and digital transformation, which was given thrice. The course participants were professionals from private and public organisations in Sweden. The empirical data originates from the professionals who made a check-in, mid-term evaluation, and evaluation after the course, resulting in 75 entries. Two researchers analysed the first two course entries inductively, forming the foundation for the first round of design principles. The course design for the third round was then revised according to its weaknesses. Based on the strengths and weaknesses found in empirical material from all three courses, the current design principles are professional pathways referring to new knowledge directly linked to real-world applications, knowledge evolution, meaning gradual integration of knowledge using seminars and examination assignments, preparedness protocol focusing on updated information and structured templates for the seminars. Further, the design principle of collaborative connection includes discussion where professionals exchange experiences, and the last principle, learning fusion, directs toward blended learning by combining face-to-face seminars and films. The revised course design, according to the design principles, implied that the number of professionals graduating and their grades increased. The findings of this study add theoretically to existing knowledge and practical implications by providing design principles that higher education teachers and other stakeholders can use to design or revise professional development courses. The design principles could be used stand-alone or combined to increase professionals' learning and satisfaction.
NGHIÊN CỨU XÂY DỰNG QUY TRÌNH BÀO CHẾ VIÊN NANG CỨNG ENTVN CHỨA PROBIOTIC ENTEROCOCCUS FAECIUM
Authors: Anh Bùi Thị Lan , Giang Hoàng , Mạnh Đào Nguyên
Published: October 2024

Nghiên cứu tiến hành xây dựng quy trình bào chế viên nang cứng EntVN từ các chủng lợi khuẩn Enterococcus faecium F26BA và F54BA được phân lập từ nguồn thực phẩm Việt Nam. Nồng độ sữa tiệt trùng để tạo sinh khối giống khởi động là 15% (w/w), thời gian tiến hành đông khô sinh khối ướt là 24 giờ, tỷ lệ tá dược độn (bột đậu nành) được trộn với sinh khối probiotic 1:4 (sinh khối:tá dược, w/w), nhiệt độ sấy 40oC trong 4 giờ thu được bột sinh khối probiotic có mật độ khuẩn lạc đạt 4,5x1010CFU/g. Bột sinh khối (460 mg/viên nang) sau khi nghiền mịn trộn với tá dược độn (20 mg/viên nang), tá dược dính (10 mg/viên nang), tá dược trơn chảy (10 mg/viên nang), tiến hành đóng nang. Viên nang EntVN thu được đạt các chỉ tiêu về khối lượng (sai số không quá 7,5%), độ rã (dưới 30 phút), các chỉ tiêu về giới hạn nhiễm khuẩn, hàm lượng kim loại nặng và lượng khuẩn lạc (3,3x1010CFU/g). Viên nang EntVN được bào chế từ các chủng lợi khuẩn bản địa với các đặc điểm dễ dàng thích nghi và phù hợp với người Việt, nguyên liệu bào chế phổ biến, quy trình đơn giản, giá thành vừa phải đáp ứng được nhu cầu thị trường Việt Nam.
THE EFFECTS OF DIFFERENT MATCHA GREEN TEA TYPES AND THE MEAN OF SUPPLEMENTATION ON COLORED FEATHER BROILERS PERFORMANCE
Authors: Vân Trần Thanh , Mỵ Nguyễn Thúy , Quyên Nguyễn Thu , Trường Nguyễn Đức , Khoa Mai Anh
Published: October 2024

Với mục đích đánh giá ảnh hưởng của các dạng chè xanh và phương pháp bổ sung chè xanh vào khẩu phần ăn cho gà thịt đến khả năng sản xuất, chúng tôi đã triển khai thí nghiệm trên 420 gà thịt King 303 từ 1- 13 tuần tuổi. Số gà thí nghiệm được chia đều vào 4 lô thí nghiệm với 3 lần lặp lại. Lô đối chứng không bổ sung chè xanh; Lô thí nghiệm 1 bổ sung 0,25% bột matcha chè xanh vào thức ăn. Lô thí nghiệm 2 bổ sung 0,25% bột matcha chè xanh, được pha vào nước uống cho gà. Lô thí nghiệm 3 bổ sung 0,25% bột búp chè xanh trộn vào thức ăn. Gà thí nghiệm đảm bảo các yếu tố đồng đều về khối lượng bắt đầu thí nghiệm, môi trường thí nghiệm, thức ăn... chỉ khác nhau về sản phẩm chế biến chè xanh và phương pháp bổ sung chè xanh. Kết quả cho thấy việc bổ sung chè xanh dạng matcha hay bột chè đã có ảnh hưởng tích cực đến khả năng sản xuất của gà thịt thí nghiệm. Lô được bổ sung chè xanh đã làm tăng khối lượng cơ thể từ 2,4-3,3% so với lô đối chứng; giảm lượng thức ăn ăn vào từ 14-18,9%; giảm tiêu tốn thức ăn từ 6,5 – 10% so với lô không bổ sung chè xanh. Bổ sung chè xanh đã có ảnh hưởng tích cực đến tỷ lệ cơ ngực nhưng chưa có ảnh hưởng đến tỷ lệ cơ đùi cũng như tỷ lệ mỡ bụng của gà thí nghiệm. Có thể sử dụng bột chè xanh hoặc bột matcha bổ sung vào khẩu phần ăn cho gà với tỷ lệ 0,25% vào thức ăn hoặc nước uống cho gà thịt.
KHẢO SÁT HÀM LƯỢNG CURCUMIN TRONG MỘT SỐ SẢN PHẨM TỪ TINH BỘT NGHỆ ĐANG LƯU HÀNH Ở ĐẮK LẮK BẰNG PHƯƠNG PHÁP SẮC KÝ LỎNG HIỆU NĂNG CAO
Authors: Chung Huỳnh Văn , Phúc Trần Lưu , Vĩnh Hà Hoàng Anh , Quỳnh Huỳnh Thị Như , Khoảng Lê Trung , Huyền Hoàng Thị Thu , Nhung Vũ Thị Hồng , Thông Nguyễn Quốc
Published: October 2024

Nghiên cứu này được tiến hành với mục đích đánh giá hàm lượng curcumin trong một số sản phẩm từ tinh bột nghệ đang lưu hành tại Đắk Lắkbằng phương pháp sắc ký lỏng hiệu năng cao (HPLC) với đầu dò PDA. Quá trình định lượng được thực hiện trên hệ thống e2695 của hãng water sử dụng cột  C18 5µm (4,6x250 mm), pha động được sử dụng là acetonitril – methanol- acid acetic 2% (60:20:20, v/v/v) với tốc dung môi là 1,0 ml/ phút và được đo tại bước sóng 426 nm. Phương pháp phân tích đã được đánh giá theo quy định của ICH với khoảng tương quan tuyến tính 0,01-300 µg/ml, giới hạn phát hiện (LOD) 0,01 µg/ml, giới hạn định lượng (LOQ) 0,033 µg/ml. Phương pháp định lượng đạt được độ đúng thông qua độ thu hồi từ 98,8 – 100,7%, độ lặp lại tốt với độ lệch chuẩn tương đối của thời gian lưu và diện tích peak tương ứng 0,072% và 1,164%. Nghiên cứu đã tiến hành trên 16 mẫu tinh bột nghệ và 4 mẫu cốm nghệ đang lưu hành tại Đắk Lắk.
HIỆU QUẢ CHẤT CHIẾT THẢO DƯỢC PHÒNG NGỪA BỆNH GAN THẬN MỦ Ở CÁ TRA (Pangasianodon hypophthalmus) CỦA CHẤT CHIẾT THẢO DƯỢC
Authors: Linh Nguyễn Thị Trúc , Huyền Hồng Mộng
Published: October 2024

Nghiên cứu được thực hiện nhằm khảo sát hoạt tính kháng vi khuẩn Edwardsiella ictaluri của các chất chiết thảo dược. Cụ thể gồm có lá duối (Streblus asper), lá kim quýt (Triphasia trifolia), lá keo dậu (Leucaena leucocephala), lá bằng lăng (Lagerstroemia speciosa), lá đinh lăng (Polyscias fruticosa), lá diếc (Limnophila aromatica), lá khế (Averrhoa carambola), lá sa kê (Artocarpus altilis), lá ngà voi (Sansevireria Cylindrica) và lá lẻ bạn (Tradescantia discolor). Nghiên cứu đánh giá hiệu quả chất chiết thảo dược thông qua các thử nhiệm in-vitro và in-vivo đối với vi khuẩn E. ictauri gây bệnh gan thân mũ trên cá tra (Pangasianodon hypophthalmus). Kết quả cho thấy 7/10 chất chiết thảo dược có hoạt tính kháng E. ictaluri, trong đó chất chiết keo dậu có hoạt tính cao nhất với đường kính vòng vô trùng 35,67 mm; MIC, MBC tương ứng 0,78 mg/mL và 2,34 mg/mL. Bổ sung chất chiết keo dậu 1% vào thức ăn sẽ hỗ trợ cá tra cải thiện tăng trưởng và tăng hoạt tính kháng khuẩn huyết thanh đối với vi khuẩn E. ictaluri. Kết quả này có thể được xem xét để nghiên cứu sâu hơn về sử dụng dược liệu như một phương pháp thay thế kháng sinh chống nhiễm bệnh do vi khuẩn trên cá tra.
Sleep Characteristics of Patients Admitted to Intensive Care Units after Major Abdominal Surgery
Authors: Kang Jiyeon , Kang Jeonghee
Published: October 2024

Purpose : The aim of this study was to investigate sleep parameters and architecture in patients admitted to the intensive care unit (ICU) on the day of abdominal surgery. Methods : A total of ten patients who underwent laparotomy under general anesthesia at the hepatopancreatobiliary surgery department of a general hospital in Busan, South Korea participated in this observational study. We measured total sleep time (TST), sleep efficiency (SE), wake after sleep onset (WASO), and sleep stages on their first night in the ICU using the WatchPAT300. Furthermore, we used nonparametric statistics to examine differences in postoperative sleep based on sedative administration. Results : The Median (IQR) TST for the participants was 399.50(263.80) minutes; the SE was 75.1 (30.4)%; the WASO rate was 27.8(30.6)%; and the WASO frequency was 5.50(8.50) times. Patients’ rapid eye movement (REM) sleep time was 114.31(87.88) minutes, with 55.8(11.9)% of N1, 18.2(5.3)% of N2, and 24.8 (11.7)% of N3 sleep stages. The sedation group had a longer TST (Z=-2.619, p =.008), higher SE (Z=-2.611, p =.008), lower WASO rate (Z=-2.611, p =.008), smaller number of WASOs (Z=-2.627, p =.008), and longer REM sleep (Z=-2.617, p =.008) compared to the non-sedation group. Conclusion : We observed a high rate of light sleep and awakenings during sleep in patients admitted to the ICU after surgery. Moreover, non-sedated patients lacked either deep or REM sleep. Sleep-improving interventions are needed for non-sedated surgical patients who are admitted to the ICU.
Analysis of Factors Affecting the Inpatient Satisfaction in Integrated Nursing Care Service Wards using a Healthcare Service Survey Database
Authors: Cho Young Shin , Hong Jiwon
Published: October 2024

Purpose : In this study, we aimed to identify factors influencing the inpatient satisfaction in integrated nursing care service wards. Methods : Using data from the 2020 and 2021 healthcare service experience surveys conducted by the Ministry of Health and Welfare, this study analyzed a weighted sample of 416,020 participants using descriptive statistics, pairedt-test, Pearson’s correlation, and multiple linear regression analyses. Results : Inpatient satisfaction in integrated nursing care service wards was most significantly affected by the experiences with nursing services and perceived health status, followed by experiences with doctor services, length of hospitalization, age, experiences with medical institution services, education level, gender, presence of chronic diseases, type of hospital, and occupation. Most significant positive impacts were associated with experiences with nursing and doctor services, especially in general hospitals and high-level facilities, among males and elderly patients ＞ 60 years old. In contrast, high education level, presence of chronic diseases, and unemployment were associated with low inpatient satisfaction. Conclusion : Effective programs and guidelines must be developed and implemented to expand and promote the integrated nursing care and medical services and overall utilization of healthcare institutions, with a special focus on person-centered care.
Effectiveness of End-of-Life Care Debriefing for Intensive Care Unit Nurses
Authors: Park Sook Hyun , Lee Jung Eun , Jung Yu-Jin , Yoo Ha Neul , Kim Yeon Su , Yi Young Hee
Published: October 2024

Purpose : This study aimed to determine the effectiveness of end-of-life care debriefing as an intervention to reduce moral distress among intensive care unit (ICU) nurses after end-of-life care. Methods : This quasiexperimental study included 104 nurses (46 in the control group and 58 in the intervention group) working in three medical ICUs and two surgical ICUs. The data collection period was from September 1, 2017, to January 31, 2018, and end-of-life care debriefing in the intervention group was implemented over three months. Debriefings were conducted in groups or individually, with eight people participating in three or more debriefings. Comparisons of end-of-life care stress, end-of-life care attitudes, and wellness between the two groups were performed using an ANCOVA. Satisfaction with the debriefing was analyzed using descriptive statistics. Results : End-of-life care stress and wellness did not differ between the groups, but there was a significant difference in end-of-life care attitudes. Overall, 50% of the participants were satisfied with the debriefing. Conclusion : Based on the finding that end-of-life care debriefing has a positive impact on ICU nurses’ attitudes toward end-of-life care, it can be used as an effective measure to reduce nurses’ moral distress. An institutional debriefing system should be established and operationalized.
Comparing the Validity of CAM-ICU and CAM-ICU-7 for Delirium Assessment based on Simulation
Authors: Kang Jiyeon , Bae Young Min
Published: October 2024

Purpose : This study aimed to compare the validity and user evaluations of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) and its 7-item version (CAM-ICU-7) for delirium assessment. Methods : Thirty-six intensive care unit (ICU) nurses from four university hospitals participated in this simulation-based methodological study. Four standardized patients with normal cognition, subsyndromal delirium, hypoactive delirium, and hyperactive delirium were recruited. The participants assessed all four standardized patients using the CAM-ICU and CAM-ICU-7. We analyzed the validity, assessment time, and user evaluations of both tools. DeLong’s test and the paired t-test were used for comparisons. Results : The CAM-ICU showed sensitivity, specificity, and accuracy of 80.6%, 94.4%, and 84.0%, respectively, with an Area Under Curve (AUC) of 87.5%. CAM-ICU-7 demonstrated a sensitivity, specificity, and accuracy of 90.7%, 97.2%, and 92.4%, respectively, with an AUC of 94.0%. The CAM-ICU-7 showed a better AUC than the CAM-ICU for detecting subsyndromal delirium (p =.029). However, the CAM-ICU-7 required more time for assessment across all patient types (p＜ .001). ICU nurses reported that the CAM-ICU was faster to administer, whereas the CAM-ICU-7 was easier to use, better at detecting delirium, more effective at reflecting changes in delirium, and had a higher intention to use in clinical practice. Conclusion : The CAM-ICU-7 demonstrated superior validity compared to the CAM-ICU. Despite requiring more time, ICU nurses evaluated the CAM-ICU-7 as more useful. These findings support using the CAM-ICU-7 for delirium assessment in ICU settings.
ПАРАНЕОПЛАСТИЧЕСКАЯ АРТРОПАТИЯ В ПРАКТИКЕ ВРАЧА РЕВМАТОЛОГА. ОПИСАНИЕ КЛИНИЧЕСКОГО СЛУЧАЯ.
Authors: М.В. Горемыкина , Г.Б. Канапиянова , А.Н. Нуртасова
Published: October 2024

Паранеопластический синдром представляет собой клинические проявления онкологической патологии, возникающие на расстоянии от первичного очага и не являющиеся следствием метастазирования или прорастания опухоли. Понятие паранеопластический синдром охватывает большую группу заболеваний разных, как по клиническим проявлениям, так и по патогенетическим механизмам. Обязательной предпосылкой для развития является процесс канцерогенеза. При этом проявления паранеопластического синдрома часто предшествуют первым клиническим признакам онкологической патологии, поэтому звание их особенностей повышает вероятность ранней диагностики рака. В данной статье представлен случай паранеопластического синдрома в ревматологической практике.

Paraneoplastic syndrome is a clinical manifestation of oncological pathology that occurs at a distance from the primary focus and is not a consequence of metastorrhea or swelling germination. The concept of paraneoplastic syndrome covers a large group of diseases, different both in clinical manifestations and in pathogenetic mechanisms. A prerequisite for development is the process of carcinogenesis. At the same time, the manifestations of the paraneoplastic syndrome often precede the first clinical signs of oncological pathology, therefore the rank of their features increases the likelihood of early diagnosis of cancer. This article presents a case of paraneoplastic syndrome in rheumatological practice.

Паранеопластикалық синдром-бұл онкологиялық патологияның клиникалық көрінісі, ол алғашқы ошақтан әлдеқайда қашықтықта орналасады және ісіктің өсуі немесе таралуымен сипатталмайды. Паранеопластикалық синдром тұжырымдамасы клиникалық көрінісі жағынан, патогенетикалық механизмі жағынан аурудың үлкен бір тобын құрайды. Дамуының негізгі көзі канцерогенез болып табылады. Соның ішінде паранеопластикалық синдром онкологиялық патологияның алғашқы клиникалық белгісі болып табылады, сондықтан оның атауы ісіктің ерте диагностикасына мүмкіндік береді. Берілген мақалада ревматологиялық тәжірибедегі паранеопластикалық синдром жағдайы көрсетілген.
CLINICAL CASE OF MULTISYSTEM INFLAMMATORY SYNDROME IN A CHILD
Authors: A.N. Seipenova , N.A. Abenova , A.S. Zhumabayeva
Published: October 2024

Coronavirus infection in children is characterized by a relatively mild course. However, in rare cases in children, it can proceed according to the adult variant in the form of a severe course of pneumonia in combination with a multisystem inflammatory syndrome. The article presents a description of a clinical case of COVID-19 in a child in the form of a multisystem inflammatory syndrome with co-infection with herpes simplex virus, cytomegalovirus. This article is intended for pediatricians, general practitioners, infectious disease specialists.

Коронавирусная инфекция у детей характеризуется относительно легким течением. Однако, в редких случаях у детей может протекать по взрослому варианту в виде тяжелого течения пневмонии в сочетании с мультисистемным воспалительным синдромом. В статье представлено описание клинического случая COVID-19 у ребенка в виде мультисистемного воспалительного синдрома с коинфекцией вирусом простого герпеса, цитомегаловирусом. Данная статья предназначена для педиатров, врачей общей практики, инфекционистов.

Коронвирусты инфекция балаларда салыстырмалы түрде жеңіл өтеді. Дегенмен, сирек жағдайда, ересектерде кездесетін мультижүйелі қабыну синдромымен қосарланған ауыр пневмония түрінде де кездеседі. Бұл мақалада баладағы COVID-19 мультижүйелі қабыну синдромының жай герпес вирусы және цитомегаловируспен коинфекциясы түріндегі клиникалық жағдайы берілген. Бұл мақала педиатрларға, жалпы тәжірибе дәрігерлеріне, инфекционисттерге арналған.
Кишечный микробиом у ВИЧ-инфицированных пациентов
Authors: Е.И. Козорез , И.О. Стома
Published: October 2024

В обзоре представлены современные данные по кишечному микробиому ВИЧ-инфицированных пациентов и его участию в прогрессировании заболевания. Показано значение нарушенного эпителиального кишечного барьера, микробной транслокации и системного воспаления при ВИЧ-инфекции. Описаны такие факторы, влияющие на микробиом, как уровень иммуносупрессии, вирусная нагрузка, пол, возраст, путь инфицирования, субтип ВИЧ, антиретровирусная терапия. Представлены основные изменения в трех наиболее доминирующих типах микробиоты: Proteobacteria, Bacteroidetes и Firmicutes.

The review presents current data on the gut microbiome of HIV-infected patients and its role in disease progression. The importance of gut barrier breach, microbial translocation and systemic inflammation in HIV infection has been shown. Described the factors affecting the gut microbiome, such as the level of immunosuppression, viral load, gender, age, route of infection, HIV subtype and antiretroviral therapy. The main changes in the 3 most dominant types of microbiota are presented: Proteobacteria, Bacteroidetes, and Firmicutes.
ALGILANAN ÖZGÜRLÜK İLE PSİKOLOJİK SAĞLAMLIK ARASINDAKİ İLİŞKİDE SERBEST ZAMAN YÖNETİMİNİN ARACI ROLÜNÜN BELİRLENMESİ
Authors: Siyahtaş Anıl , Çavuşoğlu Selçuk Bora , Güler Cemal
Published: October 2024

Araştırmanın temel amacı, algılanan özgürlüğün psikolojik sağlamlığa etkisinde serbest zaman yönetiminin aracı rolünü ortaya koymaktır. Bu doğrultuda çalışma, nicel araştırma yöntemlerinden ilişkisel tarama desenine uygun tasarlanmıştır. Araştırmanın örneklemi; serbest zaman etkinliklerine katılan bireylerden (sportif/sosyal/kültürel/sanatsal) oluşmaktadır (n=390). Veriler; Kişisel Bilgi Formu, Serbest Zamanda Algılanan Özgürlük Ölçeği (SZAÖÖ), Kısa Psikolojik Sağlamlık Ölçeği (K-PSÖ) ve Boş Zaman Yönetimi Ölçeği (BZYÖ) ile toplanarak SPSS 22 ve AMOS 16 yazılım programlarında analiz edilmiştir. Normal dağılım gösteren verilerin analizlerinde t-testi, ANOVA ve MANOVA testleri kullanılmıştır. Kavramlar arasındaki ilişkiler Pearson korelasyon analizi ile test edilirken, gruplar arasındaki farklılıklar Tukey testi ile çözümlenmiştir. Çalışmanın amacı doğrultusunda ise; serbest zamanın aracı rolünün tespitinde Yapısal Eşitlik Modellemelerinden Yol Analizi uygulanmıştır. Araştırmadaki katılımcıların yaş ortalaması 33,11 (±9,59) olup %60,5’i erkektir. Ölçeklerden alınan toplam puan ortalamaları sırasıyla SZAÖÖ x̄=3.85 (± ,46), BZYÖ x̄=3.66 (± ,54) ve K- PSÖ x̄=3.41 (± ,73) olarak tespit edilmiştir. Serbest zaman etkinliklerinde bulunan bireylerin cinsiyet, eğitim ve aktivitelere katılım durumlarına göre algıladıkları özgürlük, psikolojik sağlamlık ve serbest zaman yönetimleri arasında anlamlı farklılıklar elde edilmiştir. Sonuç olarak; algılanan özgürlük ile psikolojik sağlamlık arasında serbest zaman yönetiminin kısmi aracı rolü belirlenmiştir. Diğer bir ifadeyle; algılanan özgürlüğün psikolojik sağlamlık üzerindeki etkisi, serbest zamanı iyi yönetmek üzerinden gerçekleştiği görülmüştür.
KAÇARLAR DÖNEMİNDE MEŞRUTİYET ÖNCESİ KADIN YAŞAMI
Authors: Aslan Celal , Coşansel Sevgi
Published: October 2024

İran, günümüzde Fars ülkesi olarak adlandırılan geleneklerin kök saldığı kadim topraklardır. Hâlbuki tarihî süreç içerisinde bölgede yer alan kavimlere, devletlere baktığımızda bugünkü İran’ın kavmi yapısının salt bir Fars ülkesi ve kültürü olarak adlandırılması doğru olmayacaktır. Zira İran, genel manada tenkit ettiğimizde eski ve köklü bir medeniyet olmakla birlikte çoğu zaman Türk unsurlarının yer aldığı devlet ve hanlıklar ile yönetilen bir coğrafya olmuştur. Eski uygarlıkların başlangıcından bu yana özel bir konuma sahip olan, bulunduğu coğrafyanın özellikleri ile bir hayli uygarlığa ev sahipliği yapmış olan bu coğrafya pek çok medeniyete de ev sahipliği yapmıştır. İşte bu medeniyetlerden birisi de Türklerin oluşturduğu Kaçar Hanlığıdır. Kaçar hanedanlığı 1795 yılında siyasi kargaşadan istifade ederek İran’da yönetimi devralmış ve yaklaşık 130 yıllık hâkimiyetleri içerisinde siyasi, ekonomik ve sosyal hayatta birçok yeniliğe imza atmışlardır. Ancak buna rağmen özellikle kadınlara verilen değer ve kadının sosyal hayattaki yeriyle ilgili coğrafyaya hakim olan İran kültürünün kadınları öteleyici etkisi Kaçarlarda da Nâsırüddin Şah dönemine kadar devam etmiştir.
Relevance of Thyroid Microcarcinoma and Its Diagnosis
Authors: Dobrorodniy Volodymyr , Bedenyuk Anatolyi , Smachylo Ivan , Dobrorodniy Andrii , Burak Andrew , Bilozetska Khrystyna
Published: October 2024

Microcarcinoma is a thyroid gland cancer with a size of less than 1 cm. The aim: To determine the frequency of microcarcinoma among malignant pathologies of the thyroid gland based on fine-needle aspiration biopsies (FNAB) data. Materials and Methods: A retrospective analysis of 2490 FNAB data was conducted under ultrasound control from 2007 to 01.07. 2024 at the Ternopil Regional Clinical Hospital. FNAB results were categorized into four groups: the first group – non-diagnostic results, the second – suspicion of thyroid cancer, the third – thyroid cancer, and the fourth – benign lesions. After the Bethesda system was introduced, FNAB classifications were based on this system. Results: Thyroid cancer was diagnosed in 186 cases (7.5%). Among these, macrocarcinoma was identified in 152 cases (81.7%) and microcarcinoma in 34 cases (18.3%). The peak incidence of microcarcinoma is observed in the 40-50 age, with approximately 90% of patients being women. Microcarcinomas in solitary nodules were found in 16 cases (47%); among multinodular goiters in 18 cases (53%). In 8 cases (23.5%), microcarcinoma was associated with larger thyroid cancers (multifocal process) and in 4 cases (11.8%) with benign nodules. In 6 cases (17.7%), microcarcinomas were associated with nodules suspicious for cancer. Conclusions: Indications for FNAB should be guided by the identified sonographic characteristics (solid echostructure of the nodule; hypoechogenicity; vertical orientation of nodules; indistinct margins of the nodule; presence of microcalcifications; regional cervical lymphadenopathy with signs of malignancy).
Evaluation of Green-Electric Vehicles in Terms of "Environmentalism" with a Social Anthropological Perspective
Authors: Hayırlı Onur
Published: October 2024

The new solutions always come with new problems. The rise of green vehicles has been heralded as a significant step towards reducing the environmental impact of transportation. Electric vehicles, hybrids, and other eco-friendly alternatives have gained popularity in recent years, with promises of reduced emissions and a greener future. However, the question remains: Are green vehicles truly environmentally friendly? This comprehensive academic article delves into the environmental impact of green vehicles, considering factors such as manufacturing, energy sources, real practical use of vehicles, and their overall carbon footprint. By examining the lifecycle of green vehicles, we aim to provide a balanced assessment of their environmental benefits and challenges.
POLITICAL-ECONOMIC PARADIGM OF EU ENLARGEMENT: THE CASE OF UKRAINE
Authors: BOTELHO José , KAYUN Nataliya , SHAIKAN Andrii , HUSHKO Serhii , KULISHOV Volodymyr , LYZUN Andrii
Published: October 2024

The Copenhagen criteria define the requirements for Ukraine’s membership of the European Union: democracy guaranteed by stable institutions, a functioning market economy and the ability to implement the union’s economic, political and monetary objectives. Despite progress made in important areas, Ukraine must take further steps on reforms related to abuse of power, lack of transparency and labour migration. Joining the European Union will pose a challenge for Ukraine to reform bad practices and implement European legislation into national law. The Association Agreement and Deep and Comprehensive Free Trade, which contain economic, judicial and financial principles, should be used as a model for a gradual approach to EU policies and legislation. Ukraine’s future success depends on the reforms implemented, the ability to eradicate corruption, keep people in the country, attract foreign investment and rebuild the country, while maintaining ongoing military support to defend the integrity of Ukrainian territory.