bluuebunny/crossref_metadata_2025 huggingface dataset:
MicroRNA-1298-3p induces tumor-suppressive effects in human cervical cancer cells via post-transcriptional suppression of ONECUT2
Authors: Li Kun , Zhou Min , Zhang Yan
Published: December 2022

Recent studies have revealed the negative regulatory role of microRNA-1298-3p (miR-1298-3p) in human carcinogenesis. However, the role of miR-1298-3p is yet to be studied in cervical cancer. The present study showed significant (P=0.03) downregulation of miR-1298-3p in human cervical cancer cell lines. Overexpression of miR-1298-3p significantly (P=0.02) suppressed the proliferation of the cervical cancer cells via induction of apoptosis. The percentage of early and late apoptotic cervical cancer cells increased from 3.33% to 43.37% upon miR-1298-3p overexpression. Additionally, expression of Bax was increased and that of Bcl-2 was decreased in miR-1298-3p overexpressing cervical cancer cells. Overexpression of miR-1298-3p could also suppress migration and invasion of the cervical cancer cells. In vivo study showed that miR-1298-3p overexpression significantly (P=0.02) inhibited the xenografted tumor-growth via induction of apoptosis. In silico analysis and subsequent in vitro assays revealed that miR-1298-3p exerts its effects by targeting the expression of ONECUT2. While silencing of ONECUT2 could suppress the proliferation of cervical cancer cells, its overexpression could nullify the tumor-suppressive effects of miR-1298-3p. Collectively, the results revealed the tumor-suppressive role of miR-1298-3p in cervical cancer .and thus, indicative of its future therapeutic utility.
Music Valence Can Affect Dichotic Listening Performance
Authors: Ghaheri Fatemeh Sadat , Jalilvand Hamid , Ashayeri Hasan , Nekoutabar Raha , Makkiabadi Bahador
Published: December 2022

Background and Aim: Music can regulate the activity of brain structures that play a significant role in emotions. The perceived emotion techniques such as dichotic listening clarify the relationships between auditory emotional stimuli and hemispheric asymmetries in the auditory modality. We examined the impact of pleasantness/unpleasantness of music by Acceptable Noise Level (ANL) as a subjective measure of listeners’ willingness to accept background noise.
Methods: In this study, 32 participants rated their pleasantness with about ten songs; then, we considered the effect of preferred pleasant and unpleasant music on dichotic music listening and acceptable background noise. There were six forced attention conditions to calculate ANL, followed by measuring the most comfortable level and background noise level for each condition.
Results: The pairwise comparison analyses revealed significantly higher ANL in forced attention to pleasant music than to speech (p<0.004) and unpleasant music to the left ear (p≤0.05). The mean ANLs difference in 2 groups of right ear advantage and left ear advantage showed significant intra-hemispheric differences in the forced pleasant music attention than the forced unpleasant music attention conditions (p<0.007), and forced speech conditions (p=0.001), only in the left ear advantage group. In addition, the interaction between conditions and groups showed interhemispheric asymmetry.
Conclusion: Music valence and intra- and interhemispheric differences can affect the ANL dichotic processing and, consequently, lower noise tolerance (higher ANL) in forced pleasant music attention conditions.
Keywords: Acceptable noise level; dichotic listening test; music valence; functional laterality
Investigating the Effect of Binaural Beat Stimulation on the Annoyance of Tinnitus in Military Personnel
Authors: Moosapour Bardsiri Mohammadsaleh , Cheraghipour Parsa , Irani Majid , Mousavi Seyed Meead , Ghazi Mirsaeed Seyed Shahab
Published: December 2022

Background and Aim: Prevalence of noise-induced tinnitus is approximately twice as high among military personnel and veterans as in the general population. So they appear to have poorer quality of life. Many forms of sound therapy have been applied to reduce the effects of subjective tinnitus. This study aimed to investigate the effect of binaural beat stimulation on the annoyance of tinnitus in military personnel with the experience of acoustic trauma-induced tinnitus.
Methods: This study was conducted on 60 men with mean(SD) age 38.30(6.12) years individuals suffering from chronic tinnitus. They were randomly assigned to either the experimental group who were exposed to an audio file with an embedded binaural beat in  the alpha frequency range or the control group who were supposed to merely listen to their favorite music without any included beat stimulation. Tinnitus Handicap Inventory (THI) and Tinnitus Handicap Questionnaire (THQ) were used as outcome measures to collect the data after a period of one month.
Results: There were statistically significant differences (score decrease) between the two study groups after intervention in terms of THI (p<0.05) and THQ total score (p<0.05) and the subscales involving emotional effects of tinnitus.
Conclusion: Binaural beat stimulation in the alpha frequency range has the potential of inducing some positive effects on subjective feelings of chronic tinnitus sufferers.
Keywords: Tinnitus; binaural beat stimulation; tinnitus handicap inventory; tinnitus handicap questionnaire
The Impact of Hearing Preservation Education on the Young Adults’ Listening Behavior
Authors: Sameni Seyyed Jalal , Rahbar Nariman , Soleimani Marjan , Soltanparast Sanaz , Pourbakht Akram
Published: December 2022

Background and Aim: High-level sounds in recreational activities are known as one of the leading causes of developing noise-induced hearing loss, particularly in adolescents and young adults. Thus, this study aimed to explore the practicality of a hearing preservation education program in modifying listening behaviors concerning recreational noise exposure and Personal Listening Device (PLD) use in adolescents and young adults.
Methods: Two hundred students, both male and female (n=100, each) between 15 and 18 years old were chosen to participate. These students engaged in the hearing preservation education program and filled in pre-education, post-education, and follow-up questionnaires. The questionnaire assessed the students’ awareness, intention, attitudes, and motivation concerning recreational noise exposure and safe PLD usage. The materials were prepared by an expert panel of audiologists and then remarked as comprehensible by teachers of the target age group.
Results: There were significant differences in preferred volume levels and preferred listening levels of PLD, as well as the duration of PLD usage among pre-education, post-education, and follow-up questionnaire measurements (p<0.001). Notably, education significantly altered the students’ awareness, intention, attitudes, and motivation concerning recreational noise exposure among the three experimental conditions (p<0.001).
Conclusion: Providing a fundamental guide and effective education to adolescents and young adults will help them to use PLD safely, expand their awareness and knowledge, and consequently revise their attitudes and listening behaviors.
Keywords: Noise-induced hearing loss; personal listening device; recreational noise; hearing preservation; young adult and adolescent
Evaluation of Synaptopathy by Use of Latency Shift of Wave V Auditory Brainstem Response in the Presence of Ipsilateral Noise
Authors: Sabzinasab Zeynab , Rouzbahani Masoumeh , Toufan Reyhane , Maarefvand Mohammad
Published: December 2022

Background and Aim: Recreational and occupational noise can cause permanent  damage to the inner ear. Cochlear synaptopathy can be “hidden” because this synaptic reduction can occur without permanent hearing threshold changes. Our study aimed to assess synaptopathy in people with and without a history of occupational noise exposure by use of latency shift of wave V with masking.
Methods: In this study, 38 males were involved. All participants had normal hearing thresholds. Of 38 males, 20-male identified with exposure to occupational noise and 18 identified without occupational noise exposure. Auditory brainstem response and masked were performed.
Results: The main effect of the between-group factor was not significant in the right and left ears. But the main effect of the within-group factor in the right and left ears were significant (p<0.001 and p<0.001). Auditory brainstem response latencies at different levels in each group were significant. These results showed that there were no significant differences between latency changes in both groups.
Conclusion: In order to diagnose cochlear synaptopathy in humans it is important to use audiological test batteries in the future. There is currently no effective way to diagnose noise- induced cochlear synaptopathy in human subjects.
Keywords: Noise induce cochlear synaptopathy; auditory brainstem response; cochlear synaptopathy; hidden hearing loss
Bidirectional Inflammation-Depression Associations and the Dynamic Intersection of Inflammation with other Pathophysiological Correlates
Authors: Shamabadi Ahmad , Akhondzadeh Shahin
Published: December 2022

The Article Abstract is not available.
Demographic and Clinical Factors Associated with Re-admission in Patients Admitted to Psychiatric Hospital and Psychiatric Ward of General Hospital in 2011: A 7-Year Follow-Up after Discharge
Authors: Shahsavaripoor Behnoosh , Haghshshenas Mandana , Ahmadzad-Asl Masoud , Shariati Behnam , Naserbakht Morteza , Davoudi Farnoush
Published: December 2022

Background: The present study aimed to investigate the relationship between patients’ demographic/clinical factors and readmission.
Methods: This retrospective cohort study was conducted on all patients admitted to Iran psychiatric hospital and the Psychiatric Ward of Rasoul-e-Akram Hospital in Tehran in 2011. The study variable and post-discharge readmission status in a 7-years period until 2018 were collected by reviewing patients’ clinical charts, making telephone calls or studying patients’ records at Roozbeh Hospital. Thereafter, clinical factors such as Length of Hospital Stay (LOS), diagnosis, and medication compliance were evaluated by using statistical tests, including Meier-Kaplan survival analysis, Logrank test, and Cox regression analysis and SPSS software.
Results: The present study was conducted on 1410 inpatients, 434 women (30.8%) and 976 men (62.9%), whose most common disorder was mood disorder. The diagnoses of the patients were recorded based on DSM-IV-TR. Among the patients readmitted, the mean time to readmission was 24.94 months. Among the demographic and clinical factors, the longer length of stay, more previous hospitalizations, inpatient physical restraint, lack of therapeutic compliance, and diagnosis of psychotic disorders has increased the odds of readmission (all p<0.01).
Conclusion: To reduce the readmission rate among these patients, we need to use some methods to reduce readmission such as psychoeducation regarding nature of the disease, importance of medication adherence, and identifying warning signs that indicate the possibility of recurrence of the disease, especially more severe such as psychotic disorders. It is also recommended to avoid physical restraint, a factor of readmission risk, during hospitalization as much as possible.
Assessment of Anatomical Location and Variation of Mandibular Foramen Using Cone-Beam Computed Tomography: A Cross-Sectional Study
Authors: Valizadeh Solmaz , Tayefi Mahsima , Ghomeishi Mojtaba , Ghazizadeh Ahsaie Mitra , Jafarian Amiri Maede
Published: December 2022

Background: Determining the exact location of mandibular foramen is an important factor prior to Inferior Alveolar Nerve (IAN) block injection. The aim of this study is to assess the position of Mandibular Foramen (MF) and its variations using Cone-Beam Computed Tomography (CBCT).
Methods: This study was conducted on CBCT images of 80 females and 80 males (18 to 68 years). The distance between the MF and the anterior border of ramus (A), inferior border of mandible (B), superior border of mandible (C), and occlusal plane was measured. Data were analyzed by the student t-test, bivariate correlation analysis, paired sample t-test, and Pearson’s correlation coefficient.
Results: The mean amount of A, B and C distances, and the mean distance from the occlusal plane to the center of MF were 13.76, 24.24, 12.32, and 7.59 mm, respectively, with no significant difference between the right and left sides (p>0.05). The mean B and C distances were significantly smaller in females than males (p<0.05). The mean size of the measured angle was 43.2°. Significant correlations were noted between aging and decreased A distance, and reduction in the angle between the contralateral premolars and MF (p<0.05).
Conclusion: Knowledge about the position of MF can enhance the surgical procedures in this region. Using a 21-25 mm needle would be associated with lower risk of needle fracture during IAN block injection. Also, needle insertion angle <45-degrees is optimal for the samples assessed in this study.
Impact of the COVID Pandemic on Anesthesiology Assistants’ Educational Satisfaction, Behavior and Quality of Life
Authors: Tafrishinejad Arash , Mohseni Gholamreza , Khorasanizadeh Shayesteh , Behnaz Faranak , Sedehi Esfahani Gandomsadat , Teymourian Houman
Published: December 2022

Background: The corona pandemic has created many unpredictable challenges for the medical staff and students. In almost all countries, changes have been made in the medical education programs at all levels. The anesthesiology assistants are among the most affected groups due to the role of this specialty in the management of COVID patients.
Methods: We prepared a questionnaire including demographic information, as well as 20 questions associated with work and educational issues. The questionnaire was sent to all anesthesia assistants via SMS and the answers were collected within 5 days. The 20 main questions were designed in the form of multiple-choice questions with 5 standard options.
Results: Responses were immediately reported after categorization. Chi-square test was used to compare the answers among the subgroups, such as male and female, single and married and at different levels. 66 anesthesia assistants out of total amount of 71 at four different levels (92.9%) answered the questions. The results showed that the majority of assistants have experienced a higher level of stress during corona pandemic and the negative effects of the pandemic on their medical education were obvious.
Conclusion: According to the responses received in this study, the amount of stress in male assistants was less than females and also married assistants experienced less stress in comparison to singles.
Prevalence of Kell Ag in Pregnant Women with Thalassemia Minor or Intermedia Beta in Medical Centers Affiliated to Shiraz University of Medical Sciences in 2019-2020
Authors: Cheraghi Seyed Mohammad , Rezvani Alireza
Published: December 2022

Background: Kell Ag, the main antigen of kell system has the greatest antigenicity after Rh antigen and the associated antibodies are very important. These antibodies are mainly of the Ig G class and can cause side effects like Hemolytic disease of the Fetus and Newborn (HDFN) or Hemolytic Transfusion Reaction (HTR), especially in patients with chronic blood transfusions such as thalassemia patients. The aim of this study was to evaluate Kell antigen in pregnant women with thalassemia minor and intermedia and to determine the appropriate strategy for transfusion in this group of patients
Methods: This study is a cross-sectional study on pregnant women with thalassemia minor or intermedia. The samples were taken from patients of Shahid Motahari clinic and those with positive antigen were selected and statistically analyzed.
Results: The results showed that from the 64 patients who entered this study, the results of kell ag of 58 patients were negative and 6 were positive. Therefore, 91% of the pregnant women with beta thalassemia minor or intermedia were negative for ag kell and 9% were positive.
Conclusion: In summary, the results of this study indicated that a large percentage of pregnant women with beta-thalassemia minor or intermediate are Kell-negative, and due to the complications of alloimmunization, screening of pack cells and pregnant patients is very important.
Evaluation of Spirometric Values in Healthy Population Referred to Spirometry Centers in Hamedan City, Iran
Authors: Aloosh Oldooz , Torkashvand Mohammad , Torkashvand Amin , Mohammadi Nafiseh
Published: December 2022

Background: Spirometry procedure is known to be an efficient test for evaluating lung function. Nevertheless, the ventilatory function indexes acquired by spirometry seem to have been affected by several factors, some of which are demographic and anthropometric parameters. Hence, our study aimed to address the effect of some specific features of Hamedani individuals in Iran on spirometric characteristics.
Methods: We assessed the spirometric parameters, including Forced Vital Capacity (FVC), forced expiratory volume in the first second (FEV1), maximal mid-expiratory flow rate (FEF25-75), and FEV1/FVC ratio, obtained from normal spirometry test of 1483 individuals between the ages of 16 and 89 years.
Results: FVC, FEV1, FEV1/FVC ratio, and FEF25-75 were different between the two genders significantly (p<0.001). Even though there was a higher FVC, FEV1, and FEF25-75 in males, FEV1/FVC ratios for males were significantly lower than the ratios for females at the same ages (total mean of 82.09±6.78 in males versus 84.94±6.49 for females). In addition, FEV1/FVC ratio and FEF25-75 were not significantly different between tall males and females with a height of >170 cm. Finally, age and stature influenced the ventilatory function values with a correlation strength of <0.001.
Conclusion: Albeit men, mostly because of their particular anatomic and physiologic feature of respiratory muscles, had larger FVC and FEV1, those who were tall showed no significant change in FEV1/FVC ratio and FEF25-75, in comparison with females. Irrespective of their height, men found a higher FEF25-75 as well.
A IMPORTÂNCIA DO EXAME DE SÍFILIS NO PRÉ-NATAL
Authors: Antonia Pinheiro Cechinel Galli Ribeiro Daiane , Oliveira dos Santos Morais Meline
Published: December 2022

A sífilis é uma infecção sexualmente transmissível (IST) causada pela bactéria Treponema pallidum. A principal forma de transmissão ocorre por meio de relações sexuais desprotegidas. A sífilis também pode ser transmitida por via transplacentária na gestação, neste caso é chamada sífilis congênita (SC). A SC pode resultar em desfechos adversos na gravidez, como abortos e morte neonatal. O objetivo do presente estudo é avaliar a importância do exame de sífilis no pré-natal, a fim de verificar o impacto que o diagnóstico precoce e a implementação de medidas terapêuticas trazem a gestante e ao recém nascido. Foi realizada uma revisão de literatura com embasamento em artigos científicos através das bases de dados PubMed, Scielo e Google Acadêmico e materiais oficiais do Ministério da Saúde. Nesta pesquisa foi obeservado um aumento no número de casos de sífilis gestacional, que pode estar relacionado a maior testagem de gestantes em decorrência dos testes rápidos, mas também pode ser atribuído a falhas na assistência pré-natal e aumento no número de relações sexuais sem uso de preservativos. Fatores como a baixa escolaridade, idade, diagnóstico tardio e tratmento inadequado parecem ser determinantes para a transmissão vertical.
The Index of Major Literary Prizes in the U.S.
Authors: Grossman Claire , Spahr Juliana , Young Stephanie
Published: December 2022

The Index of Major Literary Prizes in the US includes three related datasets.
The first is a dataset of the winners and judges of prizes for prose, poetry, or unspecified genre between 1918 and 2020 with a purse of $10,000 and over. The data was collected by hand mainly from institutional websites. Gender and higher education data for individuals was collected from author biographies, interviews, and other materials. Some information about judges not listed on websites was obtained through correspondence with institutions.
The dataset includes details about the winners of fifty-two unique prizes awarded by twenty-two institutions. For a subset of thirty-nine prizes, it includes details about judges; not every prize has complete judge data. It does not include prizes awarded specifically for children’s literature, nonfiction, drama, or translation.
COMPARATIVE ANALYSIS OF THE RESULTS OF ANKYLOGLOSSIA TREATMENT IN CHILDREN
Authors: Fomenko Irina V. , Kroman Y. O , Kasatkina A. L , Timakov I. E , Khmyzova T. G , Fursik D. I
Published: December 2022

A comparative analysis of the results of treatment of children with ankyloglossia was carried out. Patients are divided into three age groups (3-6 years; 7-9 years; 10-12 years) and two subgroups depending on the method (conventional surgical and diode laser method). The immediate (14 days) and long-term (9 months) results of treatment were evaluated. The study showed the advantage of using a laser in assessing immediate results and the absence of significant differences in assessing long-term results. Regardless of the method of treatment, a higher efficiency of frenuloplasty is determined at preschool age.
THE JUSTIFICATION OF THE DEVELOPMENT NECESSITY OF A NEW CHEWING TEST
Authors: Shemonaev Viktor I. , Mashkov Aleksandr V. , Patrusheva Marina S. , Patrusheva M. S
Published: December 2022

The aim of this work is to study the advantages and disadvantages of existing chewing tests and to justify the development necessity of a new chewing test. Dynamic chewing tests can serve as a good diagnostic method to assess the quality of dental treatment. Two main groups of chewing efficiency evaluating methods can be distinguished among the existing chewing tests. These are methods conducting in accordance to the crushing degree of the solid test material and to the mixing degree of the two-color plastic test material. However, existing chewing tests are not widely used among practicing dentists as a diagnostic methods, which is caused by their complexity and duration, the negative properties of the proposed test materials. It explains the need to develop a new chewing test. According to the review of existing chewing tests, an evaluating method based on a color analysis of mixing a two-color plastic test materials currently more promising. In addition, the advantage of these methods is the high prevalence of automated results assessment. However, the automation of this process has not reached the required level for quick use in the dental office. Thus, the development of a new chewing test should be aimed at a more suitable test material selection and a simpler and more advanced automated evaluating method development.
Enforcement of Consumer Rights Through Dispute Settlement Resolution Agency to Improve the Consumer Satisfaction Index In Indonesia
Authors: Subagyono Bambang Sugeng Ariadi , Chumaida Zahry Vandawati , Romadhona Mochamad Kevin
Published: December 2022

Legal protection of consumer rights in essence is the role of the government to protect the interests of consumers in the framework of trade. Violation of consumer protection norms can only be enforced if business actors are willing to voluntarily fulfill consumer demands for the fulfillment of consumer rights that have been violated by business actors. However, if the business actor is not willing to carry it out voluntarily, while the consumer assumes that the business actor concerned has violated the consumer protection norms stipulated by the UUPK and is detrimental to the consumer, then the enforcement of the consumer protection norms can only be prosecuted through a dispute specified resolution process in the UUPK. The purpose of establishing the Consumer Dispute Settlement Agency (BPSK) is to protect consumers and business actors by creating a consumer protection system that contains elements of legal certainty and information disclosure. This study is to analyze the implementation of consumer rights enforcement through the Consumer Dispute Resolution Board in order to increase the consumer satisfaction index, as well as to analyze the obstacles and barriers to consumer rights enforcement through the Consumer Dispute Resolution Board.
A Juridical Study of Granting Wills to Heirs in the Perspective of Islamic Inheritance Law
Authors: Moechthar Oemar , Sekarmadji Agus , Katherina Ave Maria Frisa
Published: December 2022

This paper is intended to criticize the societal practices that occur, especially in Indonesia, where many heirs during their lifetime give wills to heirs who have been given a particular part in the Qur'an, which results in other (experts) heirs not getting a share or obtaining. Less than that specified in the Qur'an. One of the contributing factors is because, according to the heir, the provision of the will is to provide justice for all his heirs; however, fairness according to the heir is different from justice in the distribution of inheritance according to the Al-Qur'an and Hadith. Legal research uses this case approach as the primary analysis juxtaposed with the statutory approach and the conceptual approach as the 'knife' of analysis. The thesis or argument obtained is related to aspects of Islamic law; it is not appropriate for the heir to give a will to someone who is an heir whose part has been assigned in the Al-Quran and Hadith.
Accountability of Budget Users and Proxy Budget users on the Emergence of State Losses in the Procurement of Government Goods/Services
Authors: Rustanto
Published: December 2022

Many criminal acts of corruption originate from the procurement of goods/services which turns out to not make the application of the article on corruption crimes to matters relating to state losses or the application of corruption crimes to KPA and PA actions important to get attention, because many parties are certainly familiar with the character of law enforcement for criminal acts of corruption, which are always linked with administrative errors. Based on this background, this research raises the title: "Criminal legal responsibility for budget users and budget users authority in the procurement of government goods/services for the occurrence of state losses.” The purpose of this study is to analyze and find the ratio of the legal liability of PA and KPA in the procurement of government goods/services for the occurrence of state losses and legal consequences for the implementation of PA and KPA duties that cause state losses in the procurement of government goods/services. The research method used is legal research (doctrinal research) and the approach used is the statutory approach, case study, conceptual approach, and comparative approach. The results of this study, namely the Legis Ratio of accountability for PA and KPA for the occurrence of state losses, is because PA and KPA are state officials who have special authority which in fact is not owned by everyone, even public officials, so that, according to the legal principle of deen bevoegdheid zonder verantwoordenlijkheid (there is no authority without accountability), it is logical that, when exercising this authority, when the PA and KPA make a mistake, there are juridical consequences, but the mistakes made by the PA and KPA cannot be generalized immediately. The mistakes made by the PA and KPA must be analyzed, to find out the qualifications for the responsibilities of the PA and KPA, whether administrative, criminal, and/or civil liability. This, when associated with the ten-to-one rule principle, should not allow the PA and KPA to be held accountable for more than the mistakes made.
Women’s role in family economic resilience in the time of the Covid-19 pandemic according to Islamic perspective
Authors: Andrean Rizky , Adinugraha Hendri Hermawan , Surur Achmad Tubagus
Published: December 2022

Purpose – This paper tries to examine and explain how the role of women in the economic resilience of the family during the Covid-19 pandemic from an Islamic perspective. Methodology – The method in this research is a phenomenological study and also a descriptive analysis. This research is a literature study or library research using a qualitative research approach. This study uses secondary data originating from the publication of scientific journal articles, the results of previous studies, and other reference sources that are relevant to the thing being studied. Findings – The results of the study show that working women play a very important role in maintaining the economic resilience of the family, especially during the pandemic. However, on the other hand, women who help make a living also have their challenges, namely how they can divide their time between working to earn a living and also taking care of the household. Implications – Working women must be able to balance the roles they have. Islam allows women who work to help earn a living with the record that it is with the permission of her husband, to avoid things that are contrary to the Shari’a, and also stay away from work that is contrary to her feminine nature.Originality – Religious teachings that serve as guidelines in life will also be a separate perspective that will enrich views on how women work.
ANALISIS SPASIAL POTENSI RESAPAN AIR UNTUK MENDUKUNG PENGELOLAAN DAERAH ALIRAN SUNGAI (DAS) UNDA PROVINSI BALI (Spatial Analysis of Water Infiltration Potential to Support The Management of Unda Watershed at Bali Province)
Authors:   Ilmu Tanah dan Lingkungan, Fakultas Pertanian, Universitas Udayana, Denpasar-Bali, Wiyanti Wiyanti , Susila Ketut , Suyarto R , Saifulloh Moh ,   Pusat Pengembangan Infrastruktur Data Spasial (PPIDS), Universitas Udayana,   Magister Perencanaan Pengelolaan Pesisir dan Daerah Aliran Sungai (MPPDAS), Fakultas Geografi, UGM, Yogyakarta
Published: December 2022

The Unda Watershed is categorized as the priority watershed, which part of its area is degraded land. The condition of land cover with the dominance of low-density vegetation has implications for low infiltration and water absorption capacity, so that it has the potential to increase surface runoff. This study aims to identify the potential for water absorption as the basis for watershed management planning. The method used in this study is scoring with four parameters, namely soil type, land use, slope, and rainfall. Spatial data analysis uses Geographic Information System (GIS). The formulation of recommendations for watershed management activities is carried out descriptively, based on the findings of the analysis of water absorption potential. The results showed that the water recharge conditions in the study area were classified as good (22.54%), very critical (18.20%), normal (17.92%), and less critical (7.99%). The recommended watershed management is periodic reforestation, construction of bench/traditional terraces, construction of infiltration wells/biopori holes in the residential areas, and synergistic integration of the roles of watershed institutions from upstream to downstream.
ANALISIS TINGKAT PENYEBARAN PENCEMARAN SUNGAI TALLO DENGAN SISTEM INFORMASI GEOGRAFIS (SIG) (Analysis of the Pollution Distribution Level of the Tallo River using Geographic Information Systems (GIS))
Authors:   Departemen Teknik Lingkungan, Fakultas Teknik, Universitas Hasanuddin, Civil & Environmental Engineering Building Fakultas Teknik, Kampus Gowa, Nurhikmah Firdha , Selintung Mery , Rauf Syafruddin ,   Departemen Teknik Sipil, Fakultas Teknik, Universitas Hasanuddin, Civil & Environmental Engineering Building Fakultas Teknik, Kampus Gowa
Published: December 2022

Makassar City is one of the densely populated cities with various industrial activities. Among the 15 sub-districts in the Makassar City area, eight of them are crossed by the Tallo River. This study aims to analyze the level of spread of pollution and the water quality status of the water at the Tallo River using the parameters of temperature, TSS, pH, DO, BOD, and COD. The research was conducted by delimiting and dividing the research area into 3 river segments based on different types of land use. Sampling of Tallo River water in this study used SNI 6989.57:2008. The water quality parameters were tested in the field and in the laboratory. From the results of this study, based on the standard criteria for class II PP No. 82 of 2001, the water quality of the Tallo River at the research site in terms of physical parameters, the temperature value meets the quality criteria, while the TSS value at several points does not meet the quality standard criteria. In terms of chemical parameters, the pH and DO values meet the quality criteria, while the BOD and COD values does not. The water quality status of the Tallo River is then calculated using the Pollution Index method. Overall, it is categorized as lightly polluted. If broken down per segment, the distribution of water pollution levels in the Tallo River shows a fluctuating pattern, tending to increase at the first segment test point, decrease at the segment 2 test point, and increase again at the last segment test point.
HUBUNGAN KERAGAAN BIOFISIK DAN MORFOMETRI DAERAH ALIRAN SUNGAI (DAS) KENALI BESAR, PROVINSI JAMBI DENGAN KONDISI HIDROLOGINYA (The Relationship between The Biophysical and Morphometry of The Kenali Besar Watershed, Jambi Province with Its Hydrological Conditions
Authors:   Jurusan Agroekoteknologi Fakultas Pertanian dan Pusat Unggulan Ipteks Watershed Management and Hydropower (PUI WAHYD) Universitas Jambi, Sunarti Sunarti , Listyarini Diah , Kurniawan Agus
Published: December 2022

Watershed degradation is one of the environmental problems in many parts of Indonesia. The main environmental problem in the watershed is land-use that does not consider soil and water conservation principles. Irresponsible land use will affect the hydrological function of an area. An impaired hydrological function is one indicator of watershed damage. The aim of the study was to identify and evaluate the biophysical conditions, watershed morphometry, and its relationship with the hydrological condition of the Kenali Besar watershed. The Kenali Besar watershed covers the area of Jambi City and Muaro Jambi Regency. The research was carried out in 2020 using a survey method and the research data were analyzed descriptively. The results showed that the Kenali Besar watershed has an elongated shape with medium drainage density. The watershed morphometry shows that the Kenali Besar has a relatively fast time to peak and decline in flow as well. The analysis shows that the Kenali Besar watershed has a flood risk because the land use is dominated by residential areas (40.69%), which has a relatively low capacity and infiltration rate. The ratio of instantaneous flow rates in the middle and downstream reaches 54.10 m3/s and 57.67 m3/s, respectively
Emerging Concepts in the Paramedicine Literature to Inform the Revision of a pan-Canadian Competency Framework for Paramedics: A Restricted Review
Authors: Bolster Jennifer , Pithia Priya , Batt Alan
Published: December 2022

The National Occupational Competency Profile (NOCP) – the competency framework for paramedics in Canada – is presently undergoing revision. Since the NOCP was published in 2011, paramedic practice, healthcare and society have changed dramatically. To inform the revision, we sought to identify emerging concepts in the literature that would inform the development of competencies for paramedics. We conducted a restricted literature review and content analysis of all published and grey literature pertaining to or informing Canadian paramedicine from 2011 to 2022. Three authors performed a title and abstract, and full-text review to identify and label concepts informed by existing findings. A total of 302 articles were categorized into eleven emerging concepts related to competencies: Inclusion, Diversity, Equity, and Accessibility (IDEA) in paramedicine; Social responsiveness, justice, equity and access; Anti-racism; Healthy Professionals; Evidence Informed Practice and Systems; Complex Adaptive Systems; Learning Environment; Virtual Care; Clinical Reasoning; Adaptive Expertise; and Planetary Health. This review identified emerging concepts to inform the development of the 2023 National Occupational Standard for Paramedics (NOSP). These concepts will inform data analysis, development group discussions, and competency identification.
The Impact of Renewable Electricity Output on Sustainability in the Context of Circular Economy: A Global Perspective
Authors: Laureti Lucio , Costantiello Alberto , Leogrande Angelo
Published: December 2022

In this article we investigate the impact of “Renewable Electricity Output” on green economy in the context of circular economy for 193 countries in the period 2011-2020. We use data from World Bank ESG framework. We perform Panel Data with Fixed Effects, Panel Data with Random Effects, WLS, and Pooled OLS. Our results show that Renewable Electricity Output is positively associated, among others, to “Adjusted Savings-Net Forest Depletion” and “Renewable Energy Consumption” and negatively associated, among others, to “CO2 Emission” and “Cooling Degree Days”. Furthermore, we perform a cluster analysis implementing the k-Means algorithm optimized with the Elbow Method and we find the presence of 4 clusters. Finally, we confront seven different machine learning algorithms to predict the future level of “Renewable Electricity Output”. Our results show that Linear Regression is the best algorithm and that the future value of renewable electricity output is predicted to growth on average at a rate of 0.83% for the selected countries.
Virus classification for viral genomic fragments using PhaGCN2
Authors: Jiang Jing-Zhe , Yuan Wen-Guang , Shang Jiayu , Shi Ying-Hui , Yang Li-Ling , Liu Min , Zhu Peng , Jin Tao , Sun Yanni , Yuan Li-Hong
Published: December 2022

Viruses are the most ubiquitous and diverse entities in the biome. Due to the rapid growth of newly identified viruses, there is an urgent need for accurate and comprehensive virus classification, particularly for novel viruses. Here, we present PhaGCN2, which can rapidly classify the taxonomy of viral sequences at family level and supports the visualization of the associations of all families. We evaluate the performance of PhaGCN2 and compare it with the state-of-the-art virus classification tools, such as vConTACT2, CAT, and VPF-Class, using the widely accepted metrics. The results show that PhaGCN2 largely improves the precision and recall of virus classification, increases the number of classifiable virus sequences in the Global Ocean Virome dataset (v2.0) by 4 times, and classifies more than 90% of the Gut Phage Database. PhaGCN2 makes it possible to conduct high-throughput and automatic expansion of the database of the International Committee on Taxonomy of Viruses. The sourcecode is freely available at https://github.com/KennthShang/PhaGCN2.0 .
Smokeless Tobacco Enhance Allergic Inflammation, Exacerbation of Asthma and Oxidative Stress in Asthmatic Patients from Algeria
Authors: Khaldi Taha , Boughemara Karima , Hesnie Yasmine Khodja , Amira Aicha Beya , Messarah Mahfoud , Boumendjel Amel
Published: December 2022

Purpose
Despite their effects on human health, the link between smokeless tobacco (ST) consumption and asthma severity in asthmatic patients is still unknown. Thus, the present study aims to complete the lack of information by investigating the aggravation of inflammation, exacerbation of asthma, oxidative stress and cytotoxicity induced by ST in asthmatic patients.
Methods
The study recruited 80 male volunteers residing in Annaba town, Algeria, divided into four groups by using a questionnaire, each group consists of 20 male volunteers. Herein, biochemical parameters, hematological parameters, C-reactive protein (CRP), total IgE, interleukin-5 (IL-5), nitric oxide (NO) and oxidative stress were measured.
Results
The obtained results showed that ST clearly enhanced lung inﬂammation and exacerbation of asthma through total IgE, IL-5 and CRP increased production. In addition, ST was found to intensify oxidative stress via increased lipid peroxidation and decreased reduced glutathione (GSH) levels. Likewise, the biochemical and hematological parameters results showed that ST causes damage and inflammation to tissues.
Conclusion
Therefore, our study reveals that ST obviously enhances allergic inflammation in patients suffering from asthma.
A Novel Composite Distance Sample Entropy Method (CDSE) to investigate the effect of Different Body Postures on Heart Rate Variability and Skin Conductance
Authors: Soni Ankita , RAWAL KIRTI
Published: December 2022

Purpose: Heart Rate Variability (HRV) and Skin Conductance (SC) are two important parameters that reflect the response of the Autonomic Nervous System (ANS). In this research paper, the effect of postural change on HRV and SC has been explored. Sample entropy (SE) is one of the non-linear methods which is used to analyze HRV and SC. Conventional SE is sensitive to small signal length data and a single distance function between matched vector pairs is used in it, which made the analysis inconclusive to establish the relation between HRV and SC.
Method: This paper proposes a composite distance sample entropy method for matched vector pairs to remove the sensitivity of small-signal length data. In the proposed method, the distance between the two template vectors has been calculated using the composite distance function. To validate the superiority of the proposed method different noise signals of varied length is simulated for sample entropy calculation.
Results: A data set of 70 subjects for HRV and SC has been recorded in the position of supine and standing for this purpose. Comparative analysis has been done between the proposed and conventional methods on the selfrecorded data set using accuracy, and paired t-test,
Conclusion: The proposed method gives higher accuracy than the conventional SE method and appears to be less sensitive to the length of the signal and establishes the relation between HRV and SC in different body postures.
Kinetics evaluation of passive oxidation at high temperature of silicon nitride used in the fabrication of lightweight metal matrix composites
Authors: López-López I. I. , Contreras A. , Morales-Estrella R. , Lemus-Ruiz J.
Published: December 2022

In the present work, the passive oxidation kinetics of silicon nitride α-Si3N4 and (α+β)-Si3N4 powders at different temperatures from 1000 to 1200 °C were evaluated. Oxidation of these powders was carried out to improve wettability and pressureless infiltration of AZ91E Mg-alloy. The oxidation kinetic constant (kp) values and oxide layer depth were calculated. The oxidation kinetic constants kp, were 9.11e-16 and 6.35e-16 kg2/m4s and the oxidation depth were 4.25 nm and 3.69 nm, for α-Si3N4 and (α+β)-Si3N4, respectively. Furthermore, passive surface oxidation of silicon nitride was performed in order to achieve affinity between silicon nitride and AZ91E magnesium alloy. Therefore, the manufacture of AZ91E/Si3N4 magnesium matrix composite materials was successfully achieved by spontaneous infiltration process at a temperature of 800 °C.
Effects of fast track co-management care model on perioperative neurocognitive disorders in older patients undergoing hip fracture surgery: a multicenter retrospective cohort study
Authors: Luo Taijun , Zhang Wenchao , Duan Fangfang , Xiao Rui , Xu Tao , Wang Geng , Yang Minghui , Wu Xinbao
Published: December 2022

Background: This paper attempts to compare the effect of a co-management care model with a traditional orthopedic model on perioperative neurocognitive disorders complications in elderly hip fracture patients.
Methods: In this study, elderly hip fracture patients attending six hospitals in Beijing from November 31, 2018 to November 31, 2020 were divided into co-management care model and traditional orthopedic model according to the intention-to-treat principle. Beijing Jishuitan Hospital implemented a rapid co-management care model (OGC group), and five Beijing hospitals, including Beijing Anzhen Hospital, implemented a traditional orthopedic model (TOC group). The study used the Confusion Assessment Method (CAM) and a modified telephone interview method targeting patients' cognitive status to assess the incidence of delirium in elderly patients.
Results: A total of 2071 elderly hip surgery patients were included in the study, excluding 128 patients who received conservative treatment and 119 patients who were withdrawn from follow-up. Ultimately, 995 patients in the OGC group and 829 patients in the TOC group were included in the follow-up analysis. The incidence of perioperative neurocognitive disorders was significantly lower in the OGC group than in the TOC group (20.5% vs 69.5%, OR 0.59, 95% CI:0.53~0.65, P=0.000); the incidence of preoperative delirium was significantly lower in the OGC group than in the TOC group (10.5% vs 16.9%, OR 0.64, 95% CI:0.47-0.70, P=0.000); the incidence of postoperative delirium was also lower in the OGC group than in the TOC group (19.1% vs. 22.6%, OR 0.67, 95% CI:0.58 ~ 0.77, =0.001). Our logistic multivariate analysis also showed that the rapid fast-track co-management care model may be a protective factor against the development of neurocognitive impairment in patients in the perioperative period.
Conclusion: The fast-track co-management care model can reduce the occurrence of perioperative neurocognitive disorders in elderly patients, which is worth being promoted in clinical treatment. Key words: hip fracture, fast track, co-management care model, delirium, perioperative neurocognitive disorders.
RPL11 promotes non-small cell lung cancer cell proliferation via regulating endoplasmic reticulum stress and cell autophagy
Authors: Chen Jie , Lei Changda , Zhang Huahua , Huang Xiaoyong , Yang Yang , Liu Junli , Jia Yuna , Shi Haiyan , Zhang Yunqing , Zhang Jing , Du Juan
Published: December 2022

Background
Abnormal ribosomal proteins (RPs) biogenesis and function works importantly in tumorigenesis and development. RPL11 is a component of ribosomal 60S large subunit has different roles in different cancers. Here, we aims to unravel the novel functions of RPL11 in non-small cell lung cancer (NSCLC), especially that affecting cell proliferation.
Methods
Expression level of RPL11 in different NSCLC cell lines was detected using western blotting. The function of RPL11 in NSCLC cells were CCK-8, colony formation and scratch wound healing detected. Mechanisms of RPL11 on NSCLC cells proliferation were explored by flow cytometry, autophagy detection, and usage of an autophagy inhibitor chloroquine (CQ) and ERS inhibitor (TUDCA) .
Results
We found that RPL11 was highly expressed in NSCLC cells. Additionally, RPL11 overexpression promoted NSCLC cells proliferation and migration in vitro, and promoted the transition from G1 phase to S phase of the cell cycle. Conversely, RPL11 inhibition suppressed NSCLC cell proliferation and migration, and arrested the cell cycle in G0/G1 phase. Moreover, RPL11 promotes NSCLC cell proliferation via modulating autophagy and ERS. Expression levels of autophagy and ERS markers were induced by RPL11 overexpression, and inhibited by siRPL11. Usage of an autophagy inhibitor chloroquine (CQ) partially reverse the promotion of RPL11 on NSCLC cells proliferation. Besides, RPL11 induced autophagy markers expression could partially reversed by the ERS inhibitor (TUDCA).
Conclusions
Taken together, RPL11 has a tumor-promoting role in non-small cell lung cancer. It promote the cell proliferation of NSCLC cells by regulating ERS and autophagy.