bluuebunny/crossref_metadata_2025 huggingface dataset:
Концепція мобільного додатка підтримки бездротової передачі даних за допомогою WI-FI
Authors: Ревякін О. О. , Попков Д. М.
Published: March 2022

Робота присвячена розробці мобільного додатку для підтримки бездротової передачі даних за допомогою Wi-Fi.
Предметом дослідження є спосіб передачі даних за допомогою бездротової технології Wi-Fi. Завданням проектування є розробка мобільного додатку для бездротової передачі даних у локальній мережі, яка допоможе користувачеві в швидкої і якісної передачі даних засобами бездротових технологій за допомогою Wi-Fi. При дослідженні основних проблем предметної області, аналізі аналогів та засобів розробки було створено базу даних із використанням реляційної системи управління бази даних SQLite, використані мови програмування Kotlin, Groovy та Java, середовище розробки Android Studio та система автоматичного складання додатку Gradle.
Робота була спрямована на розробку мобільного додатку, завдяки якому люди зможуть швидко та якісно передавати файли та обмінюватись буферами обміну на різних пристроях за допомогою бездротових технологій з використанням Wi-Fi у локальній мережі. Система являє собою мобільний додаток, який допомагає людям передавати інформацію бездротовим способом у локальній мережі.
Даний програмний продукт не є вибагливим до апаратного забезпечення, що дозволяє користуватися системою кожній бажаючій людині, яка має доступ в Інтернет.
Mapping the Exposure of Pantropical Spotted Dolphins and Common Bottlenose Dolphins to Different Categories of Vessel Traffic in Maui Nui, Hawai‘i
Authors: Olson Grace L. , Stack Stephanie H. , Machernis Abigail F. , Sullivan Florence A. , Currie Jens J.
Published: March 2022

The increase and diversification of vessel traffic worldwide has resulted in a variety of known disturbances to dolphins. As a remote island chain, the Hawaiian Islands rely heavily on the marine environment for transportation, recreation, and fishing that aggregates into significant levels of vessel traffic. Given the known presence of dolphins in this region, there is a gap in knowledge regarding the relative exposure risk that vessel traffic poses to island-associated dolphin populations in Hawai‘i. This research identified the spatial distribution of pantropical spotted dolphins (Stenella attenuata) and common bottlenose dolphins (Tursiops truncatus) and determined the extent of their overlap with various categories of vessel traffic in Maui Nui, Hawai‘i. Species distribution was determined using kernel density estimates based on sighting data from 50 spotted dolphin sightings and 75 bottlenose dolphin sightings collected from 2013 to 2018. A combination of vessel GPS and Automatic Identification Systems (AIS) vessel tracks were used to quantify vessel traffic within the study area, resulting in 22,464 vessel tracks that were subsequently compiled into categories for analysis from 2014 to 2017. Risk of vessel exposure between vessels and dolphins, or co-occurrence, was determined by calculating the product of predicted dolphin density and predicted vessel density. Both species were exposed to vessel traffic risk over 100% of their distribution, but their highest exposure risk varied spatially, with high risk defined as > 0.25 on a normalized scale of low (0) to high (1) risk. The highest vessel exposure risk for spotted dolphins occurred in deeper, offshore waters, while the highest risk for bottlenose dolphins was in shallow, coastal waters. The vessel categories with the largest area of high risk to spotted dolphins were tour vessel and commercial fishing vessel traffic, while commercial transportation traffic had the highest exposure risk for bottlenose dolphins. This article provides baseline information for understanding the vulnerability of two island-associated dolphin populations to the threat of vessel traffic and highlights the differences in relative exposure risk based on species and vessel categories.
Characteristics of neutrophilic granulocytes of peripheral blood in patients with mechanical jaundice caused by cholangiocarcinoma
Authors: Smirnova O. V. , Gubanov B. G. , Kasparov E. V. , Darenskaya M. A. , Kolesnikova L. I. , Kolesnikov S. I.
Published: March 2022

Obstructive jaundice caused by cholangiocarcinoma takes a special place among malignant disorders and surgical pathology in Russia. Involvement of nonspecific immunity and the role of neutrophils in carcinogenesis are ambiguously evaluated. The aim of this study was to study functional activity of peripheral blood neutrophilic granulocytes and their phenotype in obstructive jaundice caused by cholangiocarcinoma. The study included 56 patients with obstructive jaundice associated with cholangiocarcinoma at the T2- 3N0- 1M0 stage (clinical stages II-III), and 90 apparently healthy volunteers of similar age group. Neutrophilic granulocytes were isolated from peripheral blood by means of double-density Ficoll-Urografin gradient.

Venous blood was collected in patients into vacutainers with heparin upon admission to the hospital, before the surgery was performed. Spontaneous cytokine production (IL-8, IFNá) was determined by enzyme-linked immunosorbent assay using Vector-Best diagnostic kits. To assess phagocytic activity of neutrophilic granulocytes, the phagocytic index (according to Hamburger), number of phagocytes (according to Wright) and the index of completed phagocytosis (according to Rudik, 2006) were calculated. Immunophenotyping of neutrophilic granulocytes was carried out using an FC500 flow cytometer (Beckman Coulter, USA) with monoclonal antibodies to CD11b+, CD16+, CD95+. The results were statistically analyzed using the Statistica v.12.0 software (StatSoft Inc., USA). To assess intergroup differences, the nonparametric Kruskal-Wallis tests (for three or more comparison groups) and Mann-Whitney tests (for pairwise comparison) were used. Comparison of groups for a qualitative binary trait was carried out using the two-sided Fisher’s exact test. Data are presented as Median (25 quartile-75 quartile).

The study of the functional activity of peripheral blood neutrophiles in obstructive jaundice patients caused by cholangiocarcinoma revealed an increase in their relative and absolute number, increased phagocytic index and decreased phagocytic number of neutrophilic granulocytes, increased expression of CD11b+, CD16+, CD95+ immunological markers. The changes in neutrophil secretory activity were characterized by a decrease in cytokine production (IL-2, IFNá). An increase in functional activity of neutrophilic granulocytes, along with a decrease in their cytokine production suggests that, in obstructive jaundice observed in cholangiocarcinoma at clinical stage T2-3N0-1M0, an equilibrium stage is revealed between the cells of immune system and malignant tumor.
Influence of proinflammatory cytokines on membrane rigidity and morphofunctional state of circulating neutrophils in ovarian tumors
Authors: Abakumova T. V. , Gening T. P. , Gening S. O. , Antoneeva I. I. , Peskov A. B.
Published: March 2022

Priming and activation mediated by cytokines cause transient reactions of actin polymerization in neutrophils (Nph), expansion and softening of cells, changes in receptor status, phagocytic ability, and generation of extracellular traps (NET), thus ultimately determining pro- or antitumor phenotype of Nph. To assess the effects of pro-inflammatory cytokines on membrane rigidity and morphofunctional state of neutrophils in benign tumors and ovarian cancer, the levels of circulating cytokines (IL-2, IL-18, MCP-1, TIMP-1), expression of adhesion markers (CD11b), degranulation (CD63), as well as FcãRIIIb receptors promoting phagocytosis (CD16). Ability of neutrophils to phagocytosis and the formation of NET was determined. Statistical evaluation of the data obtained was carried out using Statistica 13.0, Jamovi 1.6.5.0 software. An increase in membrane rigidity was found in benign and malignant ovarian tumors. In benign ovarian tumors, phagocytic activity and expression of CD11b were enhanced. In ovarian cancer, the number of CD11b+Nph and CD63+Nph were increased. Meaanwhile, at initial cancer stage, the ability to form NET predominates, and phagocytic activity increases with advancing ovarian cancer. Serum MCP-1 levels are elevated in benign tumors and at all stages of ovarian cancer. IL-2 is elevated at early stage and in advanced ovarian cancer. The level of IL-18 and TIMP-1 in the serum of patients with benign ovarian tumor did not differ significantly from the norm. Using multiple regression approach, the dependence of neutrophil membrane rigidity on the levels of circulating IL-2, TIMP-1, MCP-1, IL-18 was revealed in benign ovarian tumors, and a direct correlation was found between the neutrophil membrane rigidity and CD11b expression. Only IL-2 was associated with neutrophil membrane rigidity in ovarian cancer. At the same time, the rigidity of the neutrophil membrane directly correlated with CD16, CD63, expression like as with phagocytic index and inversely correlates with the number of traps. A combination of IL-2, MCP-1 and membrane rigidity of circulating neutrophils (based on multivariate analysis) could be used for differential diagnosis of ovarian cancer. Thus, in a benign ovarian tumor, circulating proinflammatory cytokines are associated with increased rigidity of neutrophil membrane and increase in their adhesion capacity. In ovarian cancer, only IL-2 is associated with altered rigidity of circulating neutrophils. Increase of the latter index is accompanied by elevated phagocytic activity and decreased ability to form NET.
Lipopolysaccharide and ARDS caused by new coronavirus infection: hypotheses and facts
Authors: Yatskov I. A. , Beloglazov V. A. , Ryapova E. I.
Published: March 2022

This review presents data from the literature that provide insight into the role of the lipopolysaccharide (LPS) of the Gram-negative bacteria in pathogenesis of acute respiratory distress syndrome (ARDS) caused by the novel SARS-CoV-2 coronavirus infection. ARDS is a syndrome of severe respiratory failure, an acutely occurring diffuse inflammatory lesion of lung tissue that develops as a nonspecific reaction to various direct (aspiration, inhalation of toxic gases), and systemic (sepsis, polytrauma) damaging factors and leading to development of acute respiratory failure (ARF), due to impaired structure of the lung parenchyma, disturbances in vascular permeability, decreased area of ventilated lung tissue. ARDS from coronavirus infection appears to have worse outcomes than ARDS from other causes. Mortality from typical ARDS at the intensive care units and hospitals is 35.3% and 40.0%, respectively, while the lethality rates for COVID-19-associated ARDS, ranged from 26% to 61.5%. Among patients who underwent artificial ventilation of the lungs, the mortality rates can range from 65.7% to 94%. Risk factors for poor outcomes include, e.g., older age, presence of concomitant diseases such as hypertension, cardiovascular disease and diabetes mellitus; decreased number of lymphocytes, kidney injury, and increased D-dimer levels. Death with ARDS in COVID-19 occurs as a result of respiratory failure (53%), respiratory failure combined with heart failure (33%), myocardial damage and circulatory failure (7%), or death from an unknown cause. A large number of studies show that bacterial LPS is directly or indirectly involved in all pathogenetic links of ARDS caused by the SARS-CoV-2 virus, i.e., worsening the course of inflammatory lung diseases due to decreased level of angiotensin-converting enzyme 2 (ACE2); increasing generation of reactive oxygen species (ROS) via NADPH oxidase and subsequent inactivation of endothelial nitric oxide synthase (eNOS) and decreasing bioavailability of endothelial NO, thus leading to endothelial dysfunction; interacting with proteins of surfactants. SP-A and SP-D, promoting early destruction of the cellular monolayers and lowering surface tension, interact with soluble CD14 receptor, which also has a pro-inflammatory effect on epithelial and endothelial cells, leading to p38MAPK activation via TLR4 receptors, causing degradation of IêBá protein and subsequent translocation of p65 NF-êB into the nucleus, thus inducing transcription of IL-6 and adhesion molecules (ICAM-1, VCAM-1 and E-selectin), and, as shown by Petruk et al. (2020), causing direct binding to the viral S protein in combination with LPS, thus enhancing activation of nuclear factor-kappa B (NF-êB) in monocytic THP-1 cells and cytokine responses in mononuclear blood cells. These pathophysiological mechanisms require further in-depth study in order to understand the nature of changes that occur in the patients with new SARS-CoV-2 infection.
Screening of cytokines in blood serum and lacrimal liquid in wet and atrophic forms of age-related macular degeneration
Authors: Neroev V. V. , Balatskaya N. V. , Neroeva N. V. , Karmokova A. G. , Ryabina M. V. , Kulikova I. G.
Published: March 2022

Cytokines play an integral role in pathogenesis of age-related macular degeneration (AMD). Of particular interest are the late stages of this disease, which causes progressive visual impairment. Therapy-induced effects of post-treatment cytokine concentrations also need to be studied, both at long and short observation terms. These studies are of vital importance if the atrophy occurs during antiangiogenic therapy. Our purpose was to study an array of 45 cytokines, in blood serum (BS) and lacrimal liquid (LL) of the patients with wet and atrophic AMD.

The study included 70 people (85 eyes) with stage 3-4 AMD according to AREDS. Depending on the form of AMD, 3 groups were discerned: I group (n = 24) included the patients with “geographic atrophy”; II group (n = 22), consisted of the patients with macular atrophy treated with antiangiogenic therapy of wet AMD; III group (n = 24), comprised the patients with a wet AMD who did not previously receive the treatment. Control group consisted of healthy volunteers (n = 25). All the groups were comparable for age and gender. The patients underwent a comprehensive ophthalmological examination to make a diagnosis. A multiplex study of the local (in the BS) and systemic (in the LL) cytokine status was carried out on a MAGPIX device (platform хMAP, Luminex Corporation, USA) in the Luminexx PONENT 3.1 software, using Procarta Plex kits (eBioscience, Austria). We determined 45 cytokines causing various biological effects, i.e., IL-1á, IL-1â, IL-1ra, IL-2, IL-4, IL-5, IL-6, IL-7, IL-9, IL-10, IL-12p70, IL-13, IL-15, IL-17A, IL-18, IL-21, IL-22, IL-23, IL-27, IL-31, IFNá, IFNã, IL-8/CXCL8, IP-10/CXCL10, SDF-1á/CXCL12, MCP-1/CCL2, MIP-1á/CCL3, MIP-1â/ CCL4, RANTES/CCL5, Eotaxin/CCL11, TNFá, TNFâ, GM-CSF, VEGF-A, VEGF-D, FGF-2, EGF, PDGF-BB, HGF, SCF, GRO-á, NGF-â, BDNF, LIF, PIGF-1.

Screening of a wide range of cytokines showing various biological effects was carried out in BS and LL of patients with atrophic and wet forms of AMD. It has been shown that the late stages of the disease are associated with local and systemic changes of pro / anti-inflammatory mediators (IL-1â, IL-1ra, IL-18, LIF), chemoattractant cytokines (IL-8/CXCL8, IP-10/CXCL10, MCP-1/CCL2, MIP-1á/CCL3, MIP-1â/ CCL4, RANTES/CCL5, Eotaxin/CCL11), hematopoietic regulators (IL-7), and growth factors with known angiogenic activity (EGF, HGF, PDGF-BB, VEGF-A). Altered concentrations of numerous chemokines, e.g., IP-10/CXCL10, SDF-1á/CXCL12, MIP-1á/CCL3, MIP-1â/CCL4, RANTES/CCL5 and Eotaxin/CCL11 (p < 0.05) in BS of the patients with atrophic and wet AMD may be of interest for the search of biomarkers associated with various clinical phenotypes of the disease and may be also helpful for development of new therapeutic strategies.
Optimal Frequency Intensity of Physical Activity to Reduce the Risk of Hypertension in the Korean Population
Authors: Son Jang-Won , Lee Sukho , Kang Minsoo , Shin Yun-A , Kim Jae-Hyun
Published: March 2022

PURPOSE: Regular physical activity (PA) is an effective lifestyle modification for preventing hypertension. This study aimed to analyze the optimal frequency of PA required to reduce the incidence of hypertension in the Korean population. Most Korean studies have included only small samples and limited age ranges.METHODS: The present study analyzed 16,299,865 participants aged ≥20 years (44.25±12.74 years) from the 2009 to 2012 Korean National Health Insurance Corporation Survey database. The International Physical Activity Questionnaire was used to assess the frequency and intensity of physical activity. Hazard ratios for incident hypertension were analyzed by physical activity participation, age, and sex using multivariable Cox proportional hazard models, with a non-regular physical activity group as reference.RESULTS: A total of 1,322,674 cases of incident hypertension were identified during the mean follow-up period of over 3 years. Hazard ratios for incident hypertension increased with age, with values of 50.4 and 56.1 for men and women in the older age group, respectively. Hazard ratios for incident hypertension were significantly lower in the regular PA group of middle-aged (4%) and older (7%) adults than in the non-regular PA group. The study revealed that moderate-to-vigorous-intensity PA 3-5 times/week was most effective in reducing the risk of incident hypertension in middle-aged and older adults but not in young adults. We observed no additional lowering of incident hypertension risk in the group undergoing moderate-to-vigorous PA at a frequency of 6-7 days/week compared to the 35 days/week group.CONCLUSIONS: We suggest PA at a frequency of 3-5 times/week for the prevention of incident hypertension in Korean adults.
Comparison of Gait variables and Relative Risk of Falls According to Walking Speed During Flat and Obstacles Walking of Fallers and Non-Fallers in Korean Elderly Women
Authors: Kang Hyun-Joo , Lee Byung-Kun
Published: March 2022

PURPOSE: The purpose of this study was to compare the gait variables and the relative risk of falling between elderly Korean women that fall and do not fall based on the walking speed during flat walking and in the presence of obstacles.METHODS: The study included 148 women, aged 65 years or older (22 fallers, aged 75.05±5.38 years; 126 non-fallers, aged 71.80±5.14 years). The gait variables were measured in a space of 9 m×1 m, and obstacle walking was measured while crossing obstacles measuring, 5 cm and 30 cm. A t-test, correlation analysis, and logistic regression analysis were performed to compare the gait variables to determine if there was a fall and to analyze the relationship and the risk ratio of a fall at a walking speed.RESULTS: Out of 148 participants, 22 participants (14.9%), fell while walking. During flat ground walking, right step length (p<.01) left step length (p<.05), and stride lengths (p<.01) were smaller in the faller group, while the stance phase (p<.01) and double-support time ratio (p<.05) were smaller in the non-faller group. In obstacle walking, slower walking speeds were observed for the 5-cm obstacles (p<.01) and 30-cm obstacles (p<.05) in the faller group. For the low-speed and medium-high speed groups, the odds ratio of the fall experience was 2.844 (1.125-7.191) (p<.05) for flat gait, 3.585 (1.354-9.491) (p<.05) for the 5 cm obstacle, and 4.877 (1.731-13.742) (p<.01) for the 30 cm obstacle. As the height of the obstacle increased, the fall odds ratio increased.CONCLUSIONS: In the faller group, the step and stride lengths were smaller during flat walking, and the walking speed of the obstacles was low. The low-speed group had a high falling experience odds ratio, and as the height of the obstacle increased, the falling experience odds ratio increased.
Effects of Resistance Training and/or Protein Supplementation on Usual Gait Speed in Postmenopausal Women: A Systematic Review and Meta-Analysis
Authors: Park Jae Ho , Oh Junghwan , Park Sok
Published: March 2022

PURPOSE: The present review aimed to verify the meta-effects of resistance training (RT) or protein supplementation (PS) on usual gait speed (UGS) in postmenopausal women and the additive effect of RT and PS on UGS.METHODS: A systematic literature search of PubMed/Medline and Web of Science (core collection) was performed from inception to December 31, 2021. Electronic search methods were used to identify 18 relevant randomized controlled trials. Meta-analyses of standardized mean difference (SMD) calculated using Hedges’ g between RT and/or PS groups versus control groups were conducted using a random-effects model. The meta-effects are presented in a forest plot with a 95% confidence interval (CI).RESULTS: The meta-analysis showed that RT significantly improved UGS (SMD, 0.40; 95% CI, 0.12-0.68; p=.006), while PS did not improve UGS (SMD, -0.17; 95% CI, -0.80 to 0.46; p=.601). A subgroup analysis indicated that there were significant increases in UGS after both ‘RT-only intervention (SMD, 0.30; 95% CI, 0.01 to 0.59; p=.046)’ and ‘RT combined with balance training (BT) (SMD, 0.65; 95% CI, 0.17-1.13; p=.008)’, while there was no significant increase in UGS after ‘RT combined with power training (PT) (SMD, -0.08; 95% CI, -0.62 to 0.45; p=.765)’. There was no additive effect on UGS after RT combined with PS (SMD, -0.06; 95% CI, -0.36 to 0.24; p=.699).CONCLUSIONS: This study revealed that RT significantly improved UGS in postmenopausal women, and adding BT to RT further improved UGS. In addition, there was no significant improvement in UGS after PS in postmenopausal women, and no additive effect on UGS after RT combined with PS.
Right hemihepatectomy for ischemic liver necrosis after cholecystectomy
Authors: Novozhilov A. V. , Movsisyan M. O. , Grigorev S. E. , Shcherbakov R. I. , Grigoryev E. G.
Published: March 2022

Injury of the extrahepatic bile duct system during cholecystectomy is a complex problem in biliary surgery. Combined injuries of the bile ducts and vessels in the hepatoduodenal ligament significantly complicate treatment and increase mortality. Efficient revascularization is possible in a specialized clinic during the initial hours following the injury. Anatomical liver resection is a rescue technique for the surgical elimination of such complications. Herein, we present a case of a patient who underwent right hemihepatectomy.
Computer-assisted and magnetic resonance imaging assessment of tumors and tumor invasion of the duodenum
Authors: Karmazanovsky G. G. , Abuladze L. R.
Published: March 2022

Aim: To present the computed tomography and magnetic resonance imaging assessments of benign and malignant duodenal tumors, pancreatic head adenocarcinoma invading the duodenum, and duodenal dystrophy.

Methods: We searched for scientific papers and clinical guidelines in the information and analytical databases PubMed and Google Scholar from the 2013–2021 period using the following search terms: duodenal neoplasms, adenocarcinoma, duodenum, duodenal neuroendocrine tumors, duodenal adenoma, gastrointestinal stromal tumor, cholangiocarcinoma, radiology, magnetic resonance imaging, computed tomography, pancreatic head cancer. Then, we examined the reference lists of all the identified studies to collate the papers that would meet the eligibility criteria.

Results: We analyzed 1494 articles, 22 of which were included in our review. From the papers published within 1992–2021, 35 articles from the reference lists were additionally included. Based on the search results, several domains of articles were clustered; the articles from those domains were reviewed and evaluated that involved the abovementioned diagnostic features.

Conclusion: The early diagnosis and selection of appropriate management methods remain extremely relevant for the treatment of duodenal tumors, and hence, require careful attention from diagnosticians and clinicians.
Comparative assessment of diagnostic value of computed tomography and contrast-enhanced ultrasound in colorectal cancer liver metastases diagnosis
Authors: Busko Ekaterina A. , Kozubova Kseniya V. , Bagnenko Sergey S. , Karachun Aleksey M. , Burovick Ilya A. , Goncharova Anastasiya B. , Kostromina Ekaterina V. , Kadyrleev Roman A. , Kurganskaya Indira H. , Shevkunov Lev N.
Published: March 2022

Aim: This study aimed to clarify the ultrasound semiotics of colorectal cancer liver metastases contrast enhancement, and perform a comparative assessment of the diagnostic efficacy of contrast-enhanced ultrasound and computed tomography (CT).

Methods: We studied 40 patients with colorectal cancer: patients receiving treatment for the disease and having newly diagnosed colorectal cancer. All patients underwent contrast-enhanced ultrasound and CT. In the cases of suspected malignancy, a trephine biopsy and a morphological examination were performed.

Results: Contrast-enhanced ultrasound and CT demonstrated comparable and high diagnostic efficacy. The sensitivity of the contrast-enhanced ultrasound in malignancy detection was 93.3%, with 90% specificity, 96.55% positive predictive value, 81.82% negative predictive value, and 92.5% accuracy. The sensitivity of contrast-enhanced CT was 93.3%, with 80% specificity, 93.33% positive predictive value, 80% negative predictive value, and 92.5% accuracy.

Conclusions: For patients with colorectal cancer with contraindications to contrast-enhanced CT, contrast-enhanced ultrasound may be used an alternative imaging option for the differential diagnosis of liver neoplasms.
Refractory ascites of complex genesis in patients with a severe combined form of extrahepatic portal hypertension
Authors: Manukyan G. V. , Musin R. A. , Lebezev V. M. , Zhigalova S. B. , Kitsenko E. A. , Burenchev D. V. , Cherkasov V. A. , Rizaeva S. A.
Published: March 2022

This study demonstrates a successful clinical outcome in a female patient with severe refractory ascites associated with a complex combined form of extrahepatic portal hypertension. The study emphasizes the need and particular importance of comprehensive diagnostics and assessment of the angioarchitectonics in the portal vein system, thorough study of the porto–hepatic circulation and central hemodynamics, as well as of other major homeokinesis disorders. Understanding the pathogenesis of the disease allows for the development of a therapeutic plan with a strictly personalized approach toward the selection and staging of various surgical interventions.
Sosyal Medyada Seyahat İmrenişinin Seyahat Etme Niyetine Etkisi
Authors: ŞEKER Ferhat , ERDEM Ahmet , UNUR Kamil
Published: March 2022

İmrenme, başkasının yaptığını yapmış olmayı istemek ya da başkasının sahip olduğuna sahip olmayı dilemek olarak tanımlanırken, seyahate imrenme; başkasının yapmış olduğu bir seyahati yapmış olmayı arzu etmektir. Sosyal medyada seyahat imrenişi ise; bir kişinin başkaları tarafından sosyal medyada yapılan seyahat, gezi, tatil paylaşımlarını gördüğünde “keşke ben de gidebilmiş olsaydım” şeklinde imrenmesidir. Sosyal medyada seyahat imrenişinin seyahat etme niyetine etkisinin yapısal eşitlik modellemesi kapsamında araştırıldığı çalışmada 775 adet geçerli anket toplanmıştır. Gerçekleştirilen analiz sonucunda sosyal medyada görülen seyahat paylaşımlarına imrenmenin, seyahat etme niyeti üzerinde güçlü bir etkisinin olduğu tespit edilmiştir. Sosyal medya kullanım kalıplarının da incelendiği çalışmada katılımcıların çoğunun günde bir-üç saat sosyal medyada vakit geçirdikleri, tatil fotoğraflarını sık sık paylaştıkları, sosyal medyayı en çok arkadaşlarını takip etme amacıyla kullandıkları ve en sık kullanılan sosyal medya uygulamasının Instagram olduğu görülmüştür. Ayrıca cinsiyet, medeni durum, yaş ve seyahat etme sıklığına göre sosyal medyada seyahat imrenişinin anlamlı bir şekilde farklılaştığı belirlenmiştir.
[RETRACTED] Greenhouse Pure CBD Gummies Shark Tank Reviews v1
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Published: March 2022

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[RETRACTED] Iron Warrior Testo Thrust Reviews – Is It Legitimate Or Scam? Shocking Ingredients? Most Popular Pills v1
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JAX - EZ Lysis Nuclei Isolation for 10x Genomics Assays v2
Authors: F F Flynn William , Courtois Elise , A Perry Greggory , L Daigle Sandra , not provided Paul.gabriel , Luo Diane , Grassmann Jessica
Published: March 2022

The purpose of this protocol is to produce single nuclei from frozen human tissues for downstream assaying with the 10x Genomics Multiome assay. This protocol has been demonstrated using Human placenta tissue as well as human Glioblastoma. This protocol is modified from Sigma Aldrich Nuclei Isolation Kit: EZ Prep protocol and 10x Chromium Demonstrated protocol for Single Cell Multiome ATAC + Gene Expression Sequencing (CG000365).
JAX - Nuclei Isolation for 10x Genomics A v1
Authors: F Flynn William , Courtois Elise , A Perry Greggory , L Daigle Sandra , Gabriel Paul , Luo Diane , Grassmann Jessica
Published: March 2022

The purpose of this protocol is to produce single nuclei from frozen human tissues for downstream assaying with the 10x Genomics Multiome assay. This protocol has been demonstrated using Human placenta tissue as well as human Glioblastoma. This protocol is modified from Sigma Aldrich Nuclei Isolation Kit: EZ Prep protocol and 10x Chromium Demonstrated protocol for Single Cell Multiome ATAC + Gene Expression Sequencing (CG000365).
JAX - EZ Lysis Nuclei Isolation for 10x Genomics Assays v2
Authors: F Flynn William , Courtois Elise , Greg Perry Greg , not provided sandy.daigle , not provided Paul.gabriel , Luo Diane , Grassmann Jessica
Published: March 2022

The purpose of this protocol is to produce single nuclei from frozen human tissues for downstream assaying with the 10x Genomics Multiome assay. This protocol has been demonstrated using Human placenta tissue as well as human Glioblastoma. This protocol is modified from Sigma Aldrich Nuclei Isolation Kit: EZ Prep protocol and 10x Chromium Demonstrated protocol for Single Cell Multiome ATAC + Gene Expression Sequencing (CG000365).
Coronavirus Genus Recognition Based on Prototype Virus Variants
Authors: Chaley M.B. , Kutyrkin V.A.
Published: March 2022

Method named as variant approach to recognizing genus of coronavirus that is based on frequency of codon distribution in viral ORF1ab and genes of structural proteins (S, M and N) was proposed in the work. This method uses modified statistics whose efficiency was demonstrated earlier for flavivirus species recognition. To recognize genus of coronavirus the variant approach considers both various combinations of several structural coronavirus genes and individual structural genes. Finally, coronavirus genus is determined in the result of analysis of all variants considered. The method proposed was developed with the help of learning sample from prototype viral variants of Alphacoronavirus, Betacoronavirus, Deltacoronavirus and Gammacoronavirus genus. Application of the variant approach to recognizing genus of coronavirus has demonstrated the approach high assurance at level of 95 %. Among all variants of joint analysis, the most reliability (98 %) in recognizing genus has been achieved if codon frequency of the ORF1ab was used. Variant approach has revealed a phenomenon of mosaic structure in coronavirus genomes, i.e., when the results of genus recognition for a few genes differ from final conclusion about coronavirus genus. It seems that such phenomenon reflects homologous recombinations of the genes between various species of the coronaviruses and plasticity of their genomes in evolutionary processes.
Cognitive disorders and dementia in postmenopausal women
Authors: Talipova I. R. , Garafieva S. M. , Mazitova M. I. , Mardieva R. R.
Published: March 2022

Cognitive dysfunction in postmenopausal women reduces their quality of life, social and family adaptation and can lead to complications such as dementia including Alzheimer's disease. Results of the studies on the potential of hormone replacement therapy in prevention of this group of disorders are controversial and require further investigation. However, following healthy lifestyle, certain diets as well as regular physical and mental activity can minimize the risks of dementia and ensure normal mental performance in old age.
The concepts of «medical care» and «medical service»: a civil-legal analysis
Authors: Ponkin I. V. , Sinelnikova V. N. , Ponkina A. A. , Blinov D. V.
Published: March 2022

The article is devoted to investigate and interpret the contents and correlation for the concepts of "medical care" and "medical service" in the context of public healthcare. Here, we demonstrate the defective features of the Russian legislation regarding accepting the necessary legal definitions for such concepts. At the same time, while performing a comprehensive formal legal analysis and applying interpretation by analogy, we provide generalizations allowing to understand the essence of the concepts analyzed as well as their inter-relationship. We interpret two definitions for the concept of "medical service", and envision that medical care vs. medical service is an ontological unit of a more general and higher level. Understanding the differences in the definitions of "medical care" and "medical service", demonstrated in the article, will be useful to healthcare organizers.
Exploring School Lived Experiences of Secondary Students with the Chronic Illness of Sickle Cell Disease Through Their Parents' Lens
Authors:   , Harden Christopher , Sloand Janet
Published: March 2022

The purpose of this qualitative study was to explore the academic and emotion of secondary students with sickle cell disease school experiences as their parents recalled them. Educators are responsible for ensuring access to quality education for all students. Students with disabilities have a legal right to a free appropriate public education under Section 504 and the Individualized Education Program (IEP The chronic illness this research will focus on is children living with sickle cell disease. Sickle cell disease is an inherited blood disorder that causes severe pain episodes when sickled blood cells get stuck in blood vessels. To explore these experiences, the researcher employed a qualitative phenomenological approach to inquiry. The researcher also employed a social constructivism approach. The qualitative data collection methods used to gain in-depth understanding were semi-structured interviews, focus groups, member checks, and some artifacts review. The researcher analyzed the literature and current educational policies (Section 504, IEP, and homebound) to understand the disparity in education opportunities. The inquiry investigated the academic challenges and socioemotional stressors and practices in school that may lead to learning gaps and psychosocial risk. The study likewise delved into the current competencies that schools should know about working effectively with this population. These problems are ominous and challenging for many sickle cell disease children and families. Once the data were collected and analyzed, the researcher presented findings, results, conclusions, and recommendations. Keywords: chronic illness, sickle cell disease, best practice, Section 504, Individualized Education Program (IEP), homebound, stressors, and social constructivism
Validity of the estimated body fat percentage by bioimpedance and skinfolds in middle-aged and elderly women
Authors: Lopes Eliane , Soares Leôncio L , Caldas Lucas R R , Cerqueira Matheus S , Marins João C B , Albuquerque Maicon R , Carneiro-Júnior Miguel A
Published: March 2022

Objectives: Verify the validity of electrical bioimpedance (BIA) and the skinfold method in estimating the percentage of body fat (% BF) in middle-aged and elderly women, using dual emission X-ray absorptiometry (DXA) as a reference method. Material and methods: The sample consisted of 106 volunteers (middle age, n = 58 [51.3 ± 4.9 years] and elderly, n = 48 [67.2 ± 5.8 years]). The volunteers were submitted to anthropometric assessments and the % BF was subsequently calculated using the Jackson and Pollock 7 skinfold protocol (7SF). The % BF was also measured using BIA and DXA. Pearson’s correlation, Bland and Altman method, effect size and repeated-measure t-test were used to test the hypotheses. Results: Although there is a moderate positive relationship between the methods evaluated for middle-aged women (DXA vs 7SF, r = 0.67; DXA vs BIA, r = 0.62) and moderate to strong for the elderly (DXA vs 7SF, r = 0.57; DXA vs BIA, r = 0.75) (p ≤ 0.05 in all analyzes), the agreement between the methods was weak (limits of agreement > ± 3.5%). Additionally, when assessing the % BF mean using each method within the groups, it was observed that there was no significant difference between the estimates only between DXA and Pollock 7SF in the elderly group. Conclusion: Therefore, both the 7SF method and the BIA are not valid for estimating body fat in the sample evaluated. It is necessary to develop equations for specific skinfolds to estimate the % BF of middle-aged and elderly women and review the equations used by the BIA.
INTRODUÇÃO AO DOSSIÊ TEMÁTICO SOBRE A ARQUEOLOGIA DA GUERRA E DA VIOLÊNCIA
Authors: Neubauer Fernanda , Kim Nam C.
Published: March 2022

Título em inglês: INTRODUCTION TO THE VOLUME ON THE ARCHAEOLOGY OF VIOLENCE AND WARFARE
Impact of the Main Threats from COVID-19 on the Labor Market in the Context of Ensuring Economic Security
Authors: Andriyiv Nataliya , Voloshchuk Kateryna , Petrukha Sergii , Orlovska Olexsandra , Kurylо Oksana
Published: March 2022

The main research background involves identifying the factor that today, in the context of a pandemic and hostilities, the issue of labor migration, the labor market is an important problem for ensuring economic security. The main purpose of the article is to determine the major threats from COVID-19 and their impact on the labor market in the context of ensuring economic security. The basis of the methodology includes several theoretical methods for determining the key factors of influence and the method of graph theory and hierarchical ordering, which made it possible to structure the level of influence of these threats. The research process included identifying the main threats that negatively affect the labor market due to the onset of the pandemic and demonstrating the proposed methodological approach to streamlining their level of influence. Research conclusions shows that we have formed a model of hierarchical ordering of the influence of the principal threats from COVID-19 on the labor market in the context of ensuring economic security. Based on the results of the study, our suggestions are the proof of the fact that in modern economic conditions, theses of comprehensive research and monitoring of all negative factors that can affect the labor market are extremely relevant.
Опыт работы с методической литературой в высшей школе
Authors: Гибралтарская О.Н.
Published: March 2022

Статья посвящена специфике методического обеспечения в высшей школе и опыту написания методических пособий и их последовательному использованию в учебном процессе.
К вопросу о типологии интернет-жанров
Authors: Титлова А.С.
Published: March 2022

Статья посвящена проблемам классификации жанров в рамках медиалингвистики и интернет-лингвистики. Существующих интернет-жанры отнесены к двум группам: гомогенные макрожанры (состоящие из одного вида жанров) и гетерогенные (включающие разные виды жанров, один из которых центральный, а другой (другие) – периферийные). Выделяются два типа жанровых связей: «горизонтальная» и «вертикальная».
Функции гиперболы в эпических жанрах узбекского фольклора
Authors: Эгамбердиева Г.М.
Published: March 2022

В данной статье рассматривается использование гиперболы в узбекских сказках и дастанах. Приводится сравнительный анализ гипербол на примере сказок «Мукбил тошотар», «Эрмана-мерган», а так же дастана «Хурилико и Хамро», «Горогли».
The technology of «Learning in collaboration» in teaching world literature in higher education
Authors: Alimova N.Kh.
Published: March 2022

This article discusses the interactive educational technology "Training in cooperation (cooperative learning)", presented in the innovative, author's method of the MHAT. The main idea of this technology is to create conditions for active joint activity of students in various educational situations, aimed at the development of critical thinking. The learning process in small academic groups relates to technologies of the humanistic direction in modern pedagogy.
Terminological and substantive distinction between the terms «Argot», «Jargon», and «Slang»
Authors: Dezhina T.P.
Published: March 2022

The views of researchers on the origin and development of the terms "jargon", "argot", "slang" are discussed in this article. The author considers various social dialects in terms of their similarities and differences. The article attempts to distinguish the concepts of slang and jargon, a brief comparative analysis of these nominations is carried out.
Cognitive approach in terminology
Authors: Karavayskaya O.S.
Published: March 2022

This article is devoted to the consideration of one of the modern methods of terminology research – cognitive. A brief history of the development of linguistics is given, the main directions in linguistics in the second half of the 20th century are shown. The definitions of the cognitive approach in linguistics are considered. As a result, the advantages of using this approach in the study of terms are revealed.
Возможная связь развития костно-суставной патологии и сахарного диабета в рамках генетического синдрома. Случай из практики
Authors: Низовибатько О.Б. , Брыксина Е.В. , Зрютина А.В.
Published: March 2022

Эндокринные заболевания, в частности сахарный диабет, часто сочетается с различными генетическими синдромами. Сахарный диабет или нарушенная толерантность к углеводам развивается на фоне генетических синдромов менее, чем в 1% случаев. Сочетания множественных экзостозов и сахарного диабета в ранее изученной литературе не было. На основании случая из практики мы постараемся предположить возможную связь развития костно-суставной патологии и сахарного диабета в рамках генетического синдрома.
Коморбидность хронической обструктивной болезни легких и артериальной гипертензии: проблема остается актуальной
Authors: Сергеева В.А.
Published: March 2022

Увеличение продолжительности жизни как одна из ведущих задач современного здравоохранения несет за собой новые вызовы практикующим врачам. У пожилых пациентов ожидаемо увеличение частоты встречаемости коморбидных состояний. Артериальная гипертензия и хроническая обструктивная болезнь легких представляют собой одну из самых распространенных коморбидных клинических ситуаций, внимание к которым приковано еще с 60-х годов XX века. Оценка общих звеньев патогенеза и факторов риска доказывает тесную взаимосвязь патологий и актуальность создания отдельных клинических рекомендаций для практического ведения таких пациентов.
Необходимость назначения витамина Д при COVID-19
Authors: Усубалиев М.Б. , Осмоналиев М.К. , Ибраимова А.Дж. , Ахмедов М.Т. , Голяева К.С.
Published: March 2022

Недостаток витамина D может стать причиной повышенных рисков летального исхода при коронавирусной инфекции. Гиповитаминоз может стать одной из причин тяжелого течения болезни, так как нехватка «витамина солнца» приводит к чрезмерной реакции иммунной системы, вызывающей цитокиновый шторм, который и становится причиной серьезных осложнений и даже комы.
Psychoemotional status of patients with excoriated acne
Authors: Shakirova A.T. , Khalikova A.U. , Zamirbekova K.Z.
Published: March 2022

Excoriated acne is an acne rash, which, due to certain actions of the patient, acquires a complicated course. The main reason for the development of complications is obsessive-compulsive disorder. The article presents risk factors for the development of the disease, the need for an integrated approach to the problem, the principles of treatment, which should be directed to both the cause - psychological disorders, and the consequence - skin manifestations.
К вопросу о проблемах защиты компьютерной информации и информационных систем в зарубежном законодательстве
Authors: Клименко Т.М. , Гончаров В.А. , Бердников А.Е.
Published: March 2022

Авторами предлагаются некоторые итоги проводимых исследований в области уголовно-правового законодательства зарубежных государств. Развитие информационно-телекоммуникационных сетей, создание многочисленных информационных систем, разработка более совершенных технических устройств - все это создает условия, облегчающие совершение преступлений в этой сфере зарубежных стран.
Особенности тактики допроса несовершеннолетнего обвиняемого
Authors: Тибилова И.В.
Published: March 2022

Как гласит Конституция Российской Федерации, человек, его права и свободы являются наивысшей ценностью. Признание, соблюдение и защита прав и свобод человека – обязанность государства (ст.2). Согласно ст.19 Конвенции о правах ребенка Генеральной ассамблеи ООН от 20 ноября 1989 г.[1], посвященной защите чести и достоинства детей от всех форм физического и психического насилия, объектом особого внимания государства должны стать права и законные интересы несовершеннолетних, попавших в сферу уголовного судопроизводства. В этой связи особенно важно, что наличествует опасная тенденция к увеличению числа несовершеннолетних, участвующих в уголовном процессе в качестве различных субъектов (потерпевших, свидетелей, лиц, совершивших общественно – опасные деяния). Отсутствие четкой регламентации их правового статуса, механизма реализации предоставленных им прав существенно ослабляет правовую защищенность этой категории граждан.[1]
Опыт внедрения электронной подписи в критических для бизнеса системах
Authors: Гусак Е.В.
Published: March 2022

В нефтегазовой компании для управления программой усовершенствования деятельности, направленной на оптимизацию затрат, повышение эффективности процессов добычи нефти используется информационная система по управлению программой оптимизации затрат (ПОЗ). В рамках данной системы разработан раздел «Карты оптимизационного мероприятия», представляющий из себя план нахождения и введения в работу оптимального решения с целью повышения эффективности процессов добычи нефти. Для утверждения карты оптимизационного мероприятия (КОМ) необходимо пройти полную цепочку согласований среди руководящих лиц предприятия. Данный процесс реализован с помощью средства криптографической защиты информации – электронной подписи. В ИС ПОЗ для реализации модуля создания и проверки электронной подписи был выбран алгоритм Elliptic Curve Digital Signature Algorithm (ECDSA), основанный на сложности решения задачи дискретного логарифмирования в группе точек эллиптической кривой. Алгоритм обладает высокой криптоустойчивостью, что особенно важно в системах критичных для бизнеса.
Разработка дверной ручки с голосовым управлением
Authors: Войделевич М.А.
Published: March 2022

Данная статья посвящена анализу проблемы использования людьми с ОВЗ, а именно ключей для открытия дверного замка, на основании этого предлагается использовать дверные замки с возможностью голосового управление, в работе также обосновывается актуальность идеи.