bluuebunny/crossref_metadata_2025 huggingface dataset:
Photophysics of Anionic Bis(4H‐imidazolato)CuI Complexes
Authors: Seidler Bianca , Tran Jens H. , Hniopek Julian , Traber Philipp , Görls Helmar , Gräfe Stefanie , Schmitt Michael , Popp Jürgen , Schulz Martin , Dietzek‐Ivanšić Benjamin
Published: September 2022

In this paper, the photophysical behavior of four panchromatically absorbing, homoleptic bis(4H‐imidazolato)CuI complexes, with a systematic variation in the electron‐withdrawing properties of the imidazolate ligand, were studied by wavelength‐dependent time‐resolved femtosecond transient absorption spectroscopy. Excitation at 400, 480, and 630 nm populates metal‐to‐ligand charge transfer, intraligand charge transfer, and mixed‐character singlet states. The pump wavelength‐dependent transient absorption data were analyzed by a recently established 2D correlation approach. Data analysis revealed that all excitation conditions yield similar excited‐state dynamics. Key to the excited‐state relaxation is fast, sub‐picosecond pseudo‐Jahn‐Teller distortion, which is accompanied by the relocalization of electron density onto a single ligand from the initially delocalized state at Franck‐Condon geometry. Subsequent intersystem crossing to the triplet manifold is followed by a sub‐100 ps decay to the ground state. The fast, nonradiative decay is rationalized by the low triplet‐state energy as found by DFT calculations, which suggest perspective treatment at the strong coupling limit of the energy gap law.
Gold‐Catalyzed Divergent Ring‐Opening Rearrangement of Cyclopropenes Enabled by Dichotomous Gold−Carbenes
Authors: Li Tingrui , Julaiti Yilitabaier , Wu Xiaopeng , Han Jie , Xie Jin
Published: September 2022

The gold‐catalyzed ring‐opening rearrangement of cyclopropenes affords an efficient route to either polysubstituted naphthols or aryl‐substituted furans. Owing to the unique dichotomy of gold−carbenes, this protocol provides a switchable reaction selectivity between naphthols and furans enabled by the use of TFP−Au(MeCN)SbF6 (tri(2‐furyl) phosphine) or PNP(AuNTf2)2 (bis(diphenylphosphino)(isopropyl) amine) as catalysts respectively. It is proposed that the gold−carbene intermediate might be involved in the cyclopropene→naphthol rearrangement while the gold‐carbocation is more likely to be involved in the cyclopropene→furan rearrangement.
Follow‐up of intraocular retinoblastoma through the quantitative analysis of conserved nuclear DNA sequences in aqueous humor from patients
Authors: Cuadrado‐Vilanova Maria , Burgueño Victor , Balaguer‐Lluna Leire , Aschero Rosario , Castillo‐Ecija Helena , Liu Jing , Perez‐Jaume Sara , Pascual‐Pasto Guillem , Olaciregui Nagore G , Gomez‐Gonzalez Soledad , Correa Genoveva , Suñol Mariona , Schaiquevich Paula , Radvanyi François , Lavarino Cinzia , Mora Jaume , Catala‐Mora Jaume , Chantada Guillermo L , Carcaboso Angel M
Published: September 2022

Fundoscopy is the standard method for diagnosis and follow‐up of intraocular retinoblastoma, but it is sometimes insufficient to discern whether tumors are inactivated following treatments. In this work, we hypothesized that the amount of conserved nuclear DNA sequences in the cell‐free DNA (cfDNA) fraction of the aqueous humor (AH) might complement fundoscopy for retinoblastoma follow‐up. To address our hypothesis, we developed highly sensitive droplet digital polymerase chain reaction (ddPCR) methods to quantify highly conserved DNA sequences of nucleus‐encoded genes (GAPDH and B4GALNT1) and of a mitochondrial gene, MT‐ATP6. We obtained AH samples during intravitreal treatments. We analyzed 42 AH samples from 25 patients with intraocular retinoblastoma and 11 AH from controls (non‐cancer patients). According to clinical criteria, we grouped patients as having progression‐free or progressive retinoblastoma. cfDNA concentration in the AH was similar in both retinoblastoma groups. Copy counts for nucleus‐derived sequences of GAPDH and B4GALNT1 were significantly higher in the AH from patients with progressive disease, compared to the AH from progression‐free patients and control non‐cancer patients. The presence of mitochondrial DNA in the AH explained that both retinoblastoma groups had similar cfDNA concentration in AH. The optimal cut‐off point for discriminating between progressive and progression‐free retinoblastomas was 108 GAPDH copies per reaction. Among patients having serial AH samples analyzed during their intravitreal chemotherapy, GAPDH copies were high and decreased below the cut‐off point in those patients responding to chemotherapy. In contrast, one non‐responder patient remained with values above the cut‐off during follow‐up, until enucleation. We conclude that the measurement of conserved nuclear gene sequences in AH allows follow‐up of intraocular retinoblastoma during intravitreal treatment. The method is applicable to all patients and could be relevant for those in which fundoscopy evaluation is inconclusive.
Giant primary low‐grade fibromyxoid sarcoma arising from the left pulmonary parenchyma: A case report and literature review
Authors: Ershadi Reza , Vahedi Matin , Jahanbin Behnaz , Tabatabaei Fatemeh‐sadat , Rafieian Shahab
Published: September 2022

Background

Low‐grade fibromyxoid sarcoma is a rare painless neoplasm that primarily grows in young adults' proximal extremities and trunks. The lungs are infrequent sites for this type of sarcoma.

Case Presentation

We reported a 26‐year‐old female that presented with a chief complaint of chest pain from a few months ago to Kasra hospital, Tehran, Iran, in August 2021. Chest computed tomography (CT) showed a hypodense mass with a well‐defined margin measuring 9.3 cm in the left upper lobe and multiple hypodense lesions with a lobulated appearance with a total diameter of 15.5 × 13.5 cm in the left lower lobe of the lung.

Conclusion

This is the largest case of primary pulmonary low‐grade fibromyxoid sarcoma (30 × 28 × 7 cm), which seemed unresectable at first evaluation. Due to the extent of the tumor, left pneumonectomy was performed, leading to attenuation of symptoms and no recurrence at a six‐month follow‐up.
Computational Mechanism Investigation of C=C Bond Hydrogenation Catalyzed by Rhodium Hydride
Authors: Jia Feiyun , Zhang Bo
Published: September 2022

The hydrogenation of unsaturated carbons is a commonly used synthetic tool in pharmaceutical and industrial production. Recently, the Norton group realized highly selective hydrogenation of C=C bonds catalyzed by a rhodium hydride. Despite the great efforts made by experimentalists, details regarding the mechanism remained unclear. In this work, detailed DFT calculations were carried out to elucidate the principal features of this transformation. For enones we find that two possible competing mechanisms proposed by the experimental groups are computationally excluded, our proposed alternative mechanism with a total barrier of 20.0 kcal mol−1 is theoretically feasible, solvent methanol to also plays a crucial role in assisting β‐hydrogenation in addition to being the hydrogen source for α‐hydrogenation, and the cross‐polarization of the substrate enone‐conjugated system to result in an enhanced charge density of the α‐carbon, which favors being hydrogenated first. For isolated alkenes, neither of the two possible competing mechanisms can be excluded computationally and which carbon atom is first hydrogenated depends on the electronic properties of the substrate itself. The combination of rhodium and C=C bonds changes the electronic properties of H on the rhodium hydride and enhances its hydrogenation activity.
Interactive effects of UV radiation and water deficit on production characteristics in upland grassland and their estimation by proximity sensing
Authors: Holub Petr , Klem Karel , Veselá Barbora , Surá Kateřina , Urban Otmar
Published: September 2022

An increase in extreme weather and changes in other conditions associated with ongoing climate change are exposing ecosystems to a very wide range of environmental drivers that interact in ways which are not sufficiently understood. Such uncertainties in how ecosystems respond to multifactorial change make it difficult to predict the impacts of environmental change on ecosystems and their functions. Since water deficit (WD) and ultraviolet radiation (UV) trigger similar protective mechanisms in plants, we tested the hypothesis that UV modulates grassland acclimation to WD, mainly through changes in the root/shoot (R/S) ratio, and thus enhances the ability of grassland to acquire water from the soil and hence maintain its productivity. We also tested the potential of spectral reflectance and thermal imaging for monitoring the impacts of WD and UV on grassland production parameters. The experimental plots were manipulated by lamellar shelters allowing precipitation to pass through or to be excluded. The lamellas were either transmitting or blocking the UV. The results show that WD resulted in a significant decrease in aboveground biomass (AB). In contrast, belowground biomass (BB), R/S ratio, and total biomass (TB) increased significantly in response to WD, especially in UV exclusion treatment. UV exposure had a significant effect on AB and BB, but only in the last year of the experiment. The differences in the effect of WD between years show that the effect of precipitation removal is largely influenced by the potential evapotranspiration (PET) in a given year and hence mainly by air temperatures, while the resulting effect on production parameters is best correlated with the water balance given by the difference between precipitation and PET. Canopy temperature and selected spectral reflectance indices showed a significant response to WD and also significant relationships with morphological (AB, R/S) and biochemical (C/N ratio) parameters. In particular, the vegetation indices NDVI and RDVI provided the best correlations of biomass changes caused by WD and thus the highest potential to remotely sense drought effects on terrestrial vegetation.
Calcium homeostasis disruption initiates rapid growth after micro‐fragmentation in the scleractinian coral Porites lobata
Authors: Lock Colin , Bentlage Bastian , Raymundo Laurie J.
Published: September 2022

Coral reefs are ecosystems under increasing threat from global climate change. Coral restoration is a tool for preserving the biological and ecological function of coral reefs by mitigating coral loss and maintaining the structural integrity and complexity of reefs. To generate the necessary stock for coral restoration, larger coral colonies are usually fragmented to generate smaller specimens for outplanting, taking advantage of the high regenerative ability of corals. In this study, we utilized RNA‐seq technology to understand the physiological responses of Porites lobata colonies to physical fragmentation and outplanting, which have thus far not been characterized. Our results demonstrate that P. lobata fragments undergoing physical injury recover through two distinct phases: rapid wound regeneration of the cut margins, followed by a slower growth phase that cements the colony to the substrate. Our study found rapid physiological responses to acute physical injury and outplanting in the coral host that involved significantly increased energy production, calcium homeostasis disruption, and endoplasmic reticulum (ER) stress leading to increased antioxidant expression and rates of protein turnover. Our results suggest that phosphoinositide‐mediated acute calcium homeostasis disruption stimulates wound recovery processes in response to physical injury. Symbiont gene expression revealed extremely low gene differences in response to fragmentation, growth, and outplanting. These results provide insight into the physiological mechanisms that allow for rapid wound healing and stabilization in response to physical injury in corals.
Nanohybrid Comprising Gold Nanoparticles – MoS2 Nanosheets for Electrochemical Sensing of Folic Acid in Serum Samples
Authors: Yadav Deepshikha , Verma Shilpi , Choudhary Jyoti , Kaur Harleen , Tiwari Pratibha , Singh Sandeep , Kushwaha Pallavi , Dubey Premshankar K. , Chandra Pranjal , Singh Surinder P.
Published: September 2022

Folic acid (FA) deficiency is associated with several clinical conditions such as megaloblastic anemia, neuropsychiatric, and pregnancy‐related syndromes, this makes FA an important metabolite to be monitored. We have fabricated an electrochemical biosensor based on gold nanoparticles decorated molybdenum disulfide nanosheets (AuNPs−MoS2NSs) nanocomposite as a transducer matrix for specific and rapid electrochemical detection of FA. Differential pulse voltammetry (DPV) studies displayed a rapid analytical response of the fabricated AuNPs−MoS2NSs/GCE sensor probe towards FA in a wide concentration range of 0.001–100 μM with a very low detection limit of 0.72±0.03 nM. The selectivity of the fabricated sensor probe has been examined in the presence of interferents such as dopamine, uric acid, ascorbic acid, glucose, and urea. The clinical potential of the fabricated biosensor was established by monitoring FA in human serum samples. The developed AuNPs−MoS2NSs/GCE sensor probe showed high reproducibility and stability, indicating its promise for FA detection in clinical settings.
Dog ownership and mental health among community‐dwelling older adults: A systematic review
Authors: Maurice Clémence , Engels Cynthia , Canouï‐Poitrine Florence , Lemogne Cédric , Fromantin Isabelle , Poitrine Eric
Published: September 2022

Background

The population is ageing, and psychiatric disorders are common in older people. Those are associated with worsened quality of life. Although the positive relationship between dog ownership and physical health has been documented, data on mental health are scarcer, especially in community‐dwelling older adults.

Objective

We sought to establish whether owning a dog was associated with a lower number of symptoms of psychological disorders in community‐dwelling older adults.

Methods

We conducted a systematic review of the literature published between January 2005 and December 2020. We analysed comparative studies of the level of insomnia and symptoms of depression and/or anxiety among community‐dwelling dog owners aged 70 and over.

Results

The search identified 191 articles, of which 117 full texts were assessed for eligibility. Five cross‐sectional studies and one before‐after with control group study (assessing a total of 25,138 older adults) were included. The mean (range) NOS score (five studies) was 6.8/9 (5–9) and the EPOC score (one study) was 2/8. The association between the presence of a dog and depressive symptoms did not appear to be significant. Regular contact with a dog was associated with fewer symptoms of anxiety. None of the studies specifically examined sleep disorders.

Conclusions

Although the presence of a dog did not appear to be related to the level of depressive symptoms among community‐dwelling older adults, there might be a beneficial relationship with anxiety. Further investigation is needed ‐ especially with regard to the type of dog and the type of relationship with the dog.
Social networks and citizenship behavior: The mediating effect of organizational identification
Authors: Zagenczyk Thomas J. , Powell E. Erin
Published: September 2022

Are employees more likely to identify with their organization and engage in helping behaviors on its behalf if the coworkers who make up their social networks identify and help the organization? We draw on social information processing theory, social learning theory, and research on diffusion of innovation to develop a model that predicts how relational (advice ties) and structural (structural equivalence) factors predict organizational identification and organizational citizenship. We argue that OI is neither a matter of individual perceptions generated in isolation, nor a simple function of the number of ties that an employee has, but that it is instead an outcome of relations and interactions with coworkers, as reflected in the social structure of the employing organization. We tested our model by conducting a social network study of employees in a construction company. Our findings show that (1) employees tend to have similar levels of OI to the OI of their advice ties; (2) employees who are structurally equivalent tend to demonstrate similar levels of OCB; (3) similarity in OI mediates the relationship between advice ties and similarity in OCB; and (4) advice ties with high and moderate levels of OI are most strongly associated with similarity in OCB. In a supplementary analysis we show that the social influence model that we tested offers a better explanation for the role that the social context plays in shaping OI than does a “more ties, more OI” model. We discuss implications for theory and practice.
Identification and validation of autophagy‐related genes in exogenous sepsis‐induced acute respiratory distress syndrome
Authors: Xie Yongpeng , Hu Wenxia , Chen Xiaobin , Ren Panpan , Ye Chongchong , Wang Yanli , Luo Jiye , Li Xiaomin
Published: September 2022

Objective

To analyze the differential expression of autophagy‐related genes of sepsis‐induced acute respiratory distress syndrome (ARDS) as potential markers for early diagnosis.

Methods

Male Sprague–Dawley rats (aged 8 weeks) were selected and randomly divided into sepsis‐induced ARDS group (n = 6) and a normal control group (n = 6). Lung tissue samples were collected for high‐throughput sequencing using Illumina HiSeq sequencing platform in the paired‐end sequencing mode. Differentially expressed genes (DEGs) were screened by DESeq. 2 software [|log2FC | ≥1 and p < .05] and autophagy‐related genes were identified using Mouse Genome Informatics. Co‐expressed autophagy‐related DEGs from these two datasets were filtered by construction of a Venn diagram. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed on these autophagy‐related DEGs and a protein interaction network was constructed using STRING and Cytoscape software to identify hub genes, which were verified by real‐time quantitative polymerase chain reaction (qRT‐PCR).

Results

A total of 42 autophagy‐related DEGs (26 upregulated genes and 16 downregulated genes) were identified. The GO and KEGG pathway analyses showed enrichment in 969 biological processes (BPs), three cellular components (CCs), eight molecular functions (MFs) and 27 signaling pathways. The protein interaction (PPI) network revealed 42 node proteins and 75 interacting edges, with an average node degree of 3.52, and an average local clustering coefficient of 0.509. Among the top 10 hub genes with the RNA‐Seq, six hub genes (Stat3, Il10, Ifng, Hmox1, Hif1a, and Nod2) were validated by qRT‐PCR (all p < .05).

Conclusion

42 potential autophagy‐related genes associated with sepsis‐induced ARDS lung injury were identified and six hub genes (Stat3, Il10, Ifng, Hmox1, Hif1a, and Nod2) may affect the development of ARDS by regulating autophagy. These results expanded our understanding of ARDS and might be useful in treatment of exogenous sepsis‐induced ARDS.
Germanium‐based monoelemental and binary two‐dimensional materials: Theoretical and experimental investigations and promising applications
Authors: Zhao Fulai , Feng Yiyu , Feng Wei
Published: September 2022

Two‐dimensional (2D) materials based on group IVA elements have attracted extensive attention owing to their rich chemical structures and novel properties. This comprehensive review focuses on the phases of Ge monoelemental and binary 2D materials including germanene and its derivatives, Ge‐IVA binary compounds, Ge‐VA binary compounds, and Ge‐VIA binary compounds. The latest progress in predictive modeling, fabrication, and fundamental and physical property modulation of their stable 2D configurations are presented. Accordingly, various interesting applications of these Ge‐based 2D materials are discussed, particularly field effect transistors, photodetectors, optical devices, catalysts, energy storage devices, solar cells, thermoelectric devices, sensors, biomedical materials, and spintronic devices. Finally, this review concludes with a few perspectives and an outlook for quickly expanding the application scope Ge‐based 2D materials based on recent developments.

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In silico investigation of nonsynonymous single nucleotide polymorphisms inBCL2apoptosis regulator gene to design novel protein‐based drugs against cancer
Authors: Fareed Muhammad Mazhar , Dutta Kunal , Dandekar Thomas , Tarabonda Herman , Skorb Ekaterina V. , Shityakov Sergey
Published: September 2022

BCL2apoptosis regulator gene encodes Bcl‐2 pro‐survival protein, which plays an important role to evade apoptosis in various cancers. Moreover, single nucleotide polymorphisms (SNPs) in theBCL2gene can be nonsynonymous (nsSNPs), which might affect the protein stability and probably its function. Therefore, we implement cutting‐edge computational techniques based on the Spherical Polar Fourier and Monte‐Carlo algorithms to investigate the impact of these SNPs on the B cell lymphoma‐2 (Bcl‐2) stability and therapeutic potential of protein‐based molecules to inhibit this protein. As a result, we identified two nsSNPs (Q118R and R129C) to be deleterious and highly conserved, having a negative effect on protein stability. Additionally, molecular docking and molecular dynamics simulations confirmed the decreased binding affinity of mutated Bcl‐2 variants to bind three‐helix bundle protein inhibitor as these mutations occurred in the protein−protein binding site. Overall, this computational approach investigating nsSNPs provides a useful basis for designing novel molecules to inhibit Bcl‐2 pro‐survival pathway in malignant cells.
Formulation, nanonisation, and characterization of Polyrhachis sp. for enhanced anticancer potential: In vitro studies
Authors: Rostamizadeh Bahar , Jalalizand Alireza , Nasiri Rozita , Ghaedi Kamran
Published: September 2022

Nanotechnology is a practical and exquisite method for enhancing the bioavailability of insect medicines. The present work deals with nano‐encapsulation of freeze‐dried Polyrhachis sp. (Pol) to increase its aqueous solubility and bioactivity. In the current study, Polyrhachis sp. was encapsulated into carbonate calcium (CaCO3) through a one‐step co‐precipitation method to produce CaCO3@Pol nanoparticles (NPs). It was characterized accordingly by FTIR, FESEM, DLS, and zeta potential analysis methods. Null CaCO3 and CaCO3@Pol particle sizes were observed in the nano range, and most of the nanoparticles had spherical shapes. The cytotoxicity evaluation of neat Pol and CaCO3@Pol was performed in vitro on human breast cancer cells (MCF7) and human gastric cancer cells (AGS) through an MTT assay. Morphological alternation studies disclosed that CaCO3@Pol‐treated cells had undergone apoptosis since shrinkage and apoptotic bodies were observed. The half‐maximal inhibitory and 50% lethal dose of neat Pol and CaCO3@Pol were calculated. Besides, the RT‐PCR technique analyzed the status of apoptosis genes such as caspase‐3, caspase‐8, caspase‐9, Bcl‐2, and Bax expressions. The molecular mechanisms provoked apoptosis through modulating pro (caspase‐8, caspase‐9, Bax) and anti‐apoptotic (Bcl‐2) mediator genes expression in AGS cells. The findings conveyed that the CaCO3@Pol is a promising biomaterial for future biomedical applications.
Two‐dimensional ultrasonography and CEUS of a case with primary biliary cholangitis and vanishing bile duct syndrome
Authors: Yu Pengzhi , Zhou Yonghe , Li Xin
Published: September 2022

Vanishing bile duct syndrome (VBDS) is a pathological concept that refers to the gradual reduction, destruction and disappearance of intrahepatic bile ducts caused by drugs, immunity, malignancy, and infections (including HIV and tuberculosis). Its clinical manifestation is cholestasis. The pathological diagnostic criteria for VBDS are the occurrence of intralobular vanishing bile ducts in more than 50% of 10 or more portal areas. At present, the diagnosis of VBDS still relies on liver biopsy. Contrast‐enhanced ultrasound has been widely used in the diagnosis of liver‐related diseases. The intravenous injection of microbubbles could enhance the observation of tissue microcirculation and significantly expand the possibility of ultrasound hemodynamic research. VBDS is a rare disease, and there are few reports on the early ultrasound and CEUS manifestations. The purpose of this report is to explore the unique performance of ultrasound and CEUS in the diagnosis of VBDS.
Genome‐wide comparison of DNA methylation patterns between yak and three cattle strains and their potential association with mRNA transcription
Authors: Xin Jin‐Wei , Chai Zhi‐Xin , Jiang Hui , Cao Han‐Wen , Chen Xiao‐Ying , Zhang Cheng‐Fu , Zhu Yong , Zhang Qiang , Ji Qiu‐Mei
Published: September 2022

Yak has evolved specific adaptative mechanisms to high‐altitude environment. Up to date, only a few studies reported the DNA methylation in yak. In the present study, genome‐wide DNA methylome and transcriptome profiles in lung, mammary, and biceps brachii muscle tissues were compared between yak and three cattle breeds (Tibetan cattle, Sanjiang cattle, and Holstein cattle). The association between differentially expressed genes (DEGs) and differentially methylated regions (DMRs) was analyzed, and the biological functions of DEGs potentially driven by DMRs were explored by KEGG enrichment analysis. Finally, we found that yak‐specific DMRs‐driven DEGs were mainly involved in neuromodulation, respiration, lung development, blood pressure regulation, cardiovascular protection, energy metabolism, DNA repair, and immune functions. The higher levels of the key genes associated with these functions were observed in yak than in cattle, suggesting that DNA methylation might regulate these genes. Overall, the present study contributes basic data at the DNA methylation level to further understand the physiological metabolism in yak.
Endoscopic hemostasis using gel immersion endoscopy for duodenal ulcer and a sigmoid colon polyp: A novel gel injection method
Authors: Jinushi Ryuhei , Tashima Tomoaki , Ishii Naoki , Fujita Akashi , Tanisaka Yuki , Mizuide Masafumi , Mashimo Yumi , Kawasaki Tomonori , Ryozawa Shomei
Published: September 2022

Gel immersion endoscopy (GIE) has gained prominence for securing a good visual field. Traditionally, OS‐1 jelly (Otsuka Pharmaceutical Factory) has been used for GIE. However, due to the presence of electrolytes, it is unsuitable for endoscopic hemostasis using a monopolar device. Therefore, VISCOCLEAR (Otsuka Pharmaceutical Factory), a new gel that does not contain electrolytes, has been developed. Moreover, unlike water or saline, VISCOCLEAR does not readily mix with blood, making it effective in visualizing gastrointestinal bleeding. We report two cases in which GIE was performed using a novel gel injection method.
X‐ray exposure in cryoballoon versus radiofrequency ablation for atrial fibrillation over 7 years: A single center study
Authors: Heinroth Konstantin , Blum Tilman , Drexler Max , Plehn Alexander , Hartkopf Thomas , Horenburg Charlotte , Sedding Daniel
Published: September 2022

Background

Facing an increasing number of radiofrequency ablation (RF) and cryoballoon ablation (CB) procedures for treatment of AF radiation exposure and its reduction is a focus point for interventional electrophysiologists.

Objective

This study evaluated the procedural parameters of the different ablation methods focusing on radiation exposure and the BMI of the patients.

Methods

One thousand one hundred and thirty‐three first procedural cases of pulmonary vein isolation in patients with paroxysmal and persistent AF treated with RF and CB‐based techniques were analyzed retrospectively over a period of 7 years focusing on the endpoints dose area product (DAP, cGycm2), fluoroscopy time (FT, min) and procedural time (PT, min).

Results

Of the 1133 patients (mean age 63.4 ± 11.4 years, BMI 28.9 ± 4.7) 335 patients received an RF procedure, 211 patients were treated with the cryoballoon first generation (CB1), and 587 patients with cryoballoon second generation (CB2), respectively. The mean DAP for the PVI was 508 ± 654 cGycm2 in RF procedures, 1077 ± 683 cGycm2 in CB1‐procedures, and 587 ± 489 cGycm2 in CB2‐procedures with fluoroscopy times significantly shorter in RF procedures (9.6 ± 5.2 min) as compared to 17.7 ± 5.9 min in CB1‐ and 16.3 ± 6.3 min in CB2‐procedures (p < .001). At the same time, the procedure duration using RF (115 ± 33.5 min) was significantly longer than both in CB1 (96 ± 16.8 min) and CB2 procedures (75 ± 15.9 min).

Conclusions

Despite longer fluoroscopy durations in the CB technique, the CB2 resulted in a comparable low radiation exposure in PVI as compared to RF, accompanied by shorter procedure durations.
Worldwide research trends on Neanderthals
Authors: Guil‐Guerrero José Luis , Manzano‐Agugliaro Francisco
Published: September 2022

Research on Neanderthals is a topic of growing interest and it may even be considered that this subject will get more attention in the future. The demise and diets of the various Neanderthal populations are controversial issues that promote heated debates. In this work, a bibliometric study of all the publications contained in the Scopus database until 2021 has been conducted, analysing more than 3800 of them. The main authors, institutions and countries researching this subject have been identified, and their future development. Furthermore, the links between the authors, the countries and the topics researched have been analysed through communities detection. The most frequent keyword on this topic is ‘fossil’. Three clearly focused research clusters in this area have been detected: those focused on molecular evolution, those focused on Neanderthal biology, and those focused on palaeoanthropology. Furthermore, it has been noted that the most central countries to the networks of collaboration are the United States, Spain, France and Germany. Research on Neanderthals is in its infancy and the appearance of new clusters is expected, such as those related to the diet and the demise of Neanderthals, considering the growing number of works recently developed on these topics.
LINC00960 regulates cell proliferation and glycolysis in pancreatic cancer through the miR‐326‐3p/TUFT1/AKT–mTOR axis
Authors: Zhou Bin , Lei Jing‐Hao , Wang Qiang , Qu Teng‐Fei , Cha Li‐Chao , Zhan Han‐Xiang , Liu Shang‐Long , Hu Xiao , Sun Chuan‐Dong , Cao Jing‐Yu , Qiu Fa‐Bo , Guo Wei‐Dong
Published: September 2022

Pancreatic cancer (PC) is a common malignant cancer characterized by high mortality and poor prognosis. LINC00690 was involved in the occurrence and progression of PC, but the underlying mechanisms require further investigation. The goal of this study was to figure out how LINC00960 mediates glycolysis in PC. LINC00960, miR‐326‐3p, and Tuftelin 1 (TUFT1) expression levels were detected in PC cell lines. LINC00960 and TUFT1 expression levels were increased in PC cells when compared with normal pancreatic cells, whereas miR‐326‐3p expression levels were decreased. The expression levels of LINC00690 affected glycolysis in PC, and inhibition of LINC00960 inhibited tumor growth in vivo. LINC00690 targeted and suppressed the expression of miR‐326‐3p. MiR‐326‐3p bound to TUFT1, and miR‐326‐3p inhibited AKT–mTOR pathway activation via TUFT1. In conclusion, the depletion of LINC00960 repressed cell proliferation and glycolysis in PC by mediating the miR‐326‐3p/TUFT1/AKT–mTOR axis. Thus, we present a novel mechanism underlying the progression of PC that suggests LINC00960 is a potential therapeutic target for this cancer.
Interactive effects of temperature and nitrogen source on the elemental stoichiometry of a polar diatom
Authors: Schiffrine Nicolas , Tremblay Jean‐Éric , Babin Marcel
Published: September 2022

A recent study hypothesized that the near‐zero temperatures that generally prevail in Arctic waters negate the influence that different nitrogen (N) sources can otherwise have on the growth and elemental stoichiometry of marine micro‐algae. Here we test this hypothesis experimentally by evaluating how temperature (0–9°C) affects the growth and elemental stoichiometry of an ecologically relevant Arctic diatom Chaetoceros gelidus growing on different N sources (ammonium, nitrate, urea) at saturating irradiance. Following an initial acclimation period in which steady growth rates were achieved under each experimental treatment, changes in cellular concentrations of chlorophyll a and particulate carbon (C), nitrogen (N), phosphorus (P), and biogenic silica (Si) were monitored. While N source effects on growth rate became manifest as temperature rose above 0°C, the estimated optimal growth temperature was similar in all cases (Topt = 8.3°C). A positive effect of temperature on the N : P ratio occurred only at 6°C. Above this temperature, the N : P ratio decreased to values close to those observed at 0°C and 3°C. By contrast, the C : N ratio remained nearly invariant between 0°C and 6°C but increased substantially at 9°C. Overall, the results suggest that the presently widespread and successful diatom C. gelidus possesses the ability to remain competitive despite ongoing environmental changes and that its responses to warming and the availability of different N sources may impact elemental fluxes in the future.
Multi‐Interfaces Regulated Polyaniline/Nano‐Fe3O4/Graphene Ternary Hybrids for Ultra‐Broadband Electromagnetic Absorption
Authors: Song Xiaolong , Chen Xiangnan , Gou Guangjun , Xu Hairui , Zhang Zhiyong , Cui Liying , Peng Tianxiang , Zhu Shibu
Published: September 2022

Graphene‐based electromagnetic absorbing materials have attracted growing attention, due to their great absorption efficiency and light weight. One common design principle is to load magnetic particles onto graphene. However, the agglomeration of magnetic nanoparticles on the graphene sheets limits further improvement in their electromagnetic absorption performances. In this work, polyaniline/nano‐Fe3O4/graphene ternary hybrids with regulated multi‐interfaces are designed by simply adjusting the adding order of graphene. The dispersion of nano‐Fe3O4 on graphene and the interactions among the ternary interfaces are synchronously controlled, which are considered to be the key factors restricting the hybrids’ performances. The polyaniline/nano‐Fe3O4/graphene ternary composites show ultra‐broadband electromagnetic absorption, with the optimal reflection loss peak reaching −57.2 dB at 11.4 GHz, and the effective bandwidth achieves 13.2 GHz, covering 4.8–18 GHz. It is found that the well dispersion of nano‐Fe3O4 can enhance the overall ferromagnetism and magnetic losses, while the modulation of the multi‐interfaces can further ameliorate the interfacial and dipole polarization, synergistically making the ultra‐broadband electromagnetic absorption. This work provides areferencing path for the design of subsequent multi‐interfacing electromagnetic absorbing materials.
How songs from growing up and viewers' attachment styles affect video ads' effectiveness
Authors: Lourenço Carlos J. S. , Isabella Giuliana , Verbeke Willem , Vo Khoi , Dimoka Angelika , Bagozzi Richard P.
Published: September 2022

We propose that the positive effect of coming‐of‐age songs on ad effectiveness arises from a mediation process where the music‐evoked interpersonal memories of growing up stored in the brain and their accompanying emotions inevitably play a role, but not so straightforwardly as previously suggested. Rather, their effects work through the heightened familiarity of and peaked preferences for coming‐of‐age songs. We also propose that these sequentially mediated effects are moderated by viewers' developmental attachment styles. We test and find support for these propositions in three multimethod studies with more than 1200 participants born between the 40s and the mid‐70s and almost 60 popular songs released between the 60s and the 2010s. We discuss the implications of our findings, namely for age‐segmented video ads, and suggest future research directions.
Diagnostic evaluation of extreme winter rainfall events over the Arabian Peninsula using high‐resolution weather research and forecasting simulations
Authors: Attada Raju , Dasari Hari Prasad , Ghostine Rabih , Kondapalli Niranjan Kumar , Kunchala Ravi Kumar , Luong Thang M. , Hoteit Ibrahim
Published: September 2022

The sensitivity of different cumulus physical parameterization schemes for simulating extreme winter precipitation events over the Arabian Peninsula (AP) is investigated using a high‐resolution weather research and forecasting (WRF) model. For winters in 2001–2016, the following three parameterization schemes are examined: (i) Kain–Fritsch (KF), (ii) Betts–Miller–Janjić (BMJ), and (iii) Grell–Freitas (GF). The simulation results suggest that the AP extreme winter rainfall events are best simulated using the KF, followed by the BMJ, in terms of spatial distribution and intensity. The spatial pattern correlation coefficient between the model‐simulated and observed rainfall is highest with KF (0.94), followed by BMJ (0.91) and GF (0.76). These results are attributed to a better representation of the moisture transport associated with upper‐tropospheric cyclonic circulation and potential vorticity intrusions. By contrast, the GF scheme fails to simulate moisture convergence and updrafts, leading to an unrealistic representation of cloud hydrometeors and an improper organization of convection and associated extreme rainfall intensities. Meanwhile, the KF and BMJ also successfully simulate the dynamics and thermodynamics of extreme rainfall events that are usually driven by synoptic forcing. The study results suggest that the choice of cumulus parameterization schemes in the WRF model is critical for reliable simulation of extreme rainfall in the hyperarid AP region.
New York county's analysis shows promise of crisis response reform
Authors: Enos Gary
Published: September 2022

Results from a year‐long pilot program to reshape behavioral health crisis response in Albany County, New York, are making a compelling case for expanding the initiative across the county. The pilot's location in a rural section of the county also has helped demonstrate a substantial unmet need for mental health services in remote communities.
Webinar: Quitting smoking could improve MH, not worsen it
Authors: Canady Valerie A.
Published: September 2022

Contrary to a common misperception that quitting smoking will worsen mental health, research presented during a webinar this month found that smoking cessation treatment for persons with mental illness may help to improve their mood by reducing anxiety, depression and stress.
Considering passenger pigeon abundance and distribution in the Late Woodland zooarchaeological record of southern Ontario, Canada
Authors: Orchard Trevor J. , Needs‐Howarth Suzanne , Hawkins Alicia L. , Lesage Louis , Guiry Eric J. , Royle Thomas C. A.
Published: September 2022

The passenger pigeon (Ectopistes migratorius) was once the most abundant bird species in North America. Flocks of these birds witnessed in the early 19th century were so vast that they were said to darken the sky for days as they passed. Early syntheses of passenger pigeon remains in archaeological contexts in the eastern United States, in contrast, found them to be relatively rare in relation to other fowl, leading to the suggestion that the colonial‐era hyper‐abundance of passenger pigeons was a post‐European‐contact phenomenon resulting from contact‐induced demographic and ecological changes. In this paper, we provide new insights into passenger pigeon historical ecology through a synthesis and GIS‐based analysis of zooarchaeological data on skeletal remains from 157 Late Woodland (ca. 900–1650 CE) sites in Ontario, Canada. Our results reveal that passenger pigeon bones are common, and often abundant, in Late Woodland archaeological assemblages in Ontario, which speaks to the species' importance to Indigenous peoples in the region. However, the relative abundance of passenger pigeon remains varies over time, suggesting longer‐term trends in their availability and/or in hunting patterns.
Association between weight‐loss history and weight loss achieved in clinical obesity management: Retrospective chart review
Authors: Kuk Jennifer L. , Kamran Elham , Wharton Sean
Published: September 2022

Objective

Weight history and its association with the weight loss achieved in a publicly funded clinical obesity management program were examined in 9348 patients.

Methods

Weight history (frequency and magnitude of weight losses) was collected through questionnaires at enrollment, and weight change was assessed with retrospective electronic medical chart review.

Results

The majority of patients reported developing overweight prior to the age of 40 years and having lost at least 4.5 kg (10 lb) of weight at least once in their lifetime. Those who had an earlier onset of overweight had a higher frequency of past weight loss and had more cumulative weight loss over their lifetime. In women, but not men, earlier age of overweight onset and lifetime weight loss were associated with modestly greater weight loss at the clinic.

Conclusions

Women with greater weight‐loss history also have modestly greater weight loss at the obesity management clinic. Thus, successful long‐term obesity management, particularly for women, may include a series of repeated attempts at weight loss that should not be viewed as failures but could be viewed instead as practice.
When lightning strikes twice: Perceptions of oncology social workers about working with families with two members in treatment
Authors: Barnhart Meredith , Berkman Cathy , Mapp Susan C.
Published: September 2022

Objective

Families with a parent and child concurrently receiving cancer treatment are not common, but their needs are typically more complex than families with only one member in treatment. They have a heightened sense of loss, vulnerability, and mortality. The study purpose was to: (1) describe quality of life, social support, resiliency, and loss for these families; and (2) describe how healthcare teams can support these families.

Methods

This was a qualitative study with 20 oncology social workers who had worked with families with a parent and child concurrently receiving treatment for cancer within the past five years. The interview included questions about the emotional, social, financial, and other needs of these families, as well as their social support, quality of life, loss, and resiliency.

Results

Three themes emerged from the data: 1. Increased demands on the family with a concurrent cancer treatment, including emotional, financial, and logistical challenges for the ill parent and child and for the healthy parent and siblings; 2. Greater resilience and coping skills were experienced by some families; and 3. Implications for the healthcare team, including emotional distress in treating these families, challenges in treatment adherence, and providing the necessary support to these families.

Conclusion

Supporting these families is challenging for social workers and other members of the healthcare team. Understanding the emotional, financial and logistical needs of these families, and coordinating their care across the adult and pediatric teams, will better support the patients, as well as the healthcare providers who work with them.
Synthesis, Characterization and UV‐Crosslinking of Aromatic (Co)polycarbonates Bearing Pendant Azido Groups
Authors: Nagane Samadhan S. , Kuhire Sachin S. , Ichake Amol B. , Talanikar Aniket A. , Lochab Bimlesh , Wadgaonkar Prakash P.
Published: September 2022

A new series of (co)polycarbonates bearing pendent azido groups was synthesized by polycondensation of varying molar proportions of 4, 4’‐(5‐azidopentane‐2, 2‐diyl) diphenol and bisphenol‐A with triphosgene. The chemical structures, compositions and random nature of (co)polycarbonates were confirmed by NMR spectroscopy. Inherent viscosities and number‐average molecular weights of (co)polycarbonates were in the range 0.63–0.77 dL g−1 and 35,400–43,400 g mol−1, respectively indicating the formation of reasonably high molecular weight polymers. (Co)polycarbonates could be cast into tough, transparent and flexible films from chloroform solutions. (Co)polycarbonates were further characterized using IR spectroscopy, XRD, TGA and DSC. The thermal crosslinking of (co)polycarbonates bearing pendant azido groups was studied by DSC analysis. Independently, (co)polycarbonates bearing pendant azido groups were exposed to UV irradiation at wavelength of 254 nm and decomposition reaction of azido groups was monitored by FT‐IR spectroscopy. The complete decomposition of azido groups was observed with exposure time of 30 min. The formed cross‐linked (co)polycarbonates exhibited improved % char yield values compared to parent (co)polycarbonates. The measurement of mechanical properties of representative crosslinked (co)polycarbonates indicated increase in tensile strength and Young's modulus and decrease in % elongation compared to corresponding parent linear (co)polycarbonates.
Optimization of Evaporative Light Scattering Detector using Response Surface Methodology for Liquid Chromatography Analysis of Frondoside A
Authors: Tasfiyati Aprilia Nur , Prasetia Hafiizh , Muzdalifah Dian , Ramadhaningtyas Dillani Putri , Andreas Andreas , Yuliani Fitri , Majalis Asep Nurohmat , Ernawati Teni
Published: September 2022

Response surface methodology is employed to investigate the optimum evaporative light scattering detector (ELSD) operating conditions for high performance liquid chromatography (HPLC) analysis of frondoside A, which is a bioactive compound valuable for its anti‐cancer activity. The results suggest that ELSD response is mostly affected by nebulizing gas flow rate and evaporator temperature. The optimum response of frondoside A is achieved by adjusting ELSD evaporator and nebulizer temperature at 80 °C and 35 °C, respectively, with nebulizing gas flow rate of 0.9 SLM. The analysis of variance (ANOVA) test results demonstrated that the established model can successfully describe the relationship between the signal response and ELSD experimental parameters, and predict the optimum ELSD parameters for frondoside A analysis. Furthermore, analytical method validation performed in optimum conditions shows that the proposed method also exhibits adequate sensitivity and linearity, with acceptable precision and accuracy. The results demonstrate the suitability of HPLC‐ELSD technique for the development of routine analysis procedures of frondoside A in natural product samples.
Efficient Near‐Infrared PbS Quantum Dot Solar Cells Employing Hydrogenated In2O3 Transparent Electrode
Authors: Ge Ciyu , Yang Erqi , Zhao Xinzhao , Yuan Can , Li Sen , Dong Chong , Ruan Yingfeng , Fu Liuchong , He Yuming , Zeng XiangBin , Song Haisheng , Hu Bin , Chen Chao , Tang Jiang
Published: September 2022

Infrared solar cells are regarded as candidates for expanding the solar spectrum of c‐Si cells, and the window electrodes are usually transparent conductive oxide (TCO) such as widely used indium tin oxide material. However, due to the low transmittance of the TCO in the near‐infrared region, most near‐infrared light cannot penetrate the electrode and be absorbed by the active layer. Here, the propose a simple procedure to fabricate the window materials with high near‐infrared transmittance and high electrical conductivity, namely the hydrogen‐doped indium oxide (IHO) films prepared by room temperature magnetron sputtering. The low‐temperature annealed IHO conductive electrodes exhibit high mobility of 98 cm2 V−1 s−1 and high infrared transmittance of 85.2% at 1300 nm, which endows the lead quantum dot infrared solar cell with an improved short‐circuit current density of 37.2 mA cm−2 and external quantum efficiency of 70.22% at 1280 nm. The proposed preparation process is simple and compatible with existing production lines, which gifts the IHO transparent conductive film great potential in broad applications that simultaneously require high infrared transmittance and high conductivity.