bluuebunny/crossref_metadata_2025 huggingface dataset:
Seismic Performance of Deposit Slopes With Underlying Bedrock Before and After Reinforcement by Stabilising Piles
Authors: Sun Zhiliang , Lingwei Kong , Wei Bai , Yong Wang
Published: March 2021

The seismic performance of stabilising piles used to reinforce underlying bedrock in a deposit slope is a complex soil-structure interaction problem, on which there is limited design guidance on the optimum use of a single row of rock-socketed piles to reinforce such slopes. Two centrifuge shaking-table model tests at a geometric scale of 1:50 were conducted to ascertain the dynamic responses of the underlying bedrock deposit slopes without and with the use of stabilising piles during an earthquake. Multi-stage seismic waves with various peak accelerations were applied from the bottom of each model. Under seismic excitation, the differences in the response accelerations between the deposit and bedrock increase significantly with the increase in amplitude of the input seismic waves. The two are prone to uncoordinated movement, which leads to slope instability. Setting stabilising piles reduces the crest settlement and angular deformation and changes the natural frequency of the slope crest. The presence of the rock-socketed stabilising piles can bridge the uncoordinated movement of the bedrock and the overlying deposit to some extent. According to the mobilised pile bending moment, shear force, lateral pile-soil load distribution, and pile displacement, the dynamic response characteristics of stabilising piles under continuous multi-level seismic excitation were analysed. The resultant force arising from a distributed load increment on the piles caused by an earthquake is mainly concentrated in the upper part (the point of action of the resultant force is 1.54m below the slope surface). With increases in the peak ground acceleration (PGA) of the input motion, the resistance of the bedrock in front of the stabilising piles increases; moreover, with the increase of PGA, the peak resistance under the bedrock surface of the stabilising piles gradually moves downwards. This finding indicates that the strong seismic motion significantly changes the embedded working state of the stabilising pile.
Dual targeting of cytokine storm and viral replication in COVID-19 by plant-derived steroidal pregnanes in silico
Authors: Gyebi Gideon A. , Ogunyemi Oludare M. , Ibrahim Ibrahim M. , Afolabi Saheed O. , Adebayo Joseph O.
Published: March 2021

The high morbidity and mortality rate of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection arises majorly from the Acute Respiratory Distress Syndrome and “cytokine storm” syndrome, which is sustained by an aberrant systemic inflammatory response and elevated pro-inflammatory cytokines. Thus, phytocompounds with broad-spectrum anti-inflammatory activity that target multiple SARS-CoV-2 proteins will enhance the development of effective drugs against the disease. In this study, an in-house library of 106 steriodal plant-derived pregnanes (PDPs) was docked in the active regions of human glucocorticoid receptors (hGRs) in a comparative molecular docking analysis. Based on the minimal binding energy and a comparative dexamethason binding mode analysis, a list of top twenty ranked PDPs docked in the agonist conformation of hGR, with binding energies ranging between -9.8 and -11.2 Kcal/mol, was obtained and analyzed for interactions with the human Janus kinases 1 and Interleukins-6 and SARS-CoV-2 3-chymotrypsin-like protease, Papain-like protease and RNA-dependent RNA polymerase. For each target protein, the top three ranked PDPs were selected. Eight PDPs (bregenin, hirundigenin, anhydroholantogenin, atratogenin A, atratogenin B, glaucogenin A, glaucogenin C and glaucogenin D) with high binding tendencies to the catalytic residues of multiple targets were identified. A high degree of structural stability was observed from the 100 ns molecular dynamics simulation analyses of glaucogenin C and hirundigenin complexes of hGR. The selected top-eight ranked PDPs demonstrated favourable druggable and in silico ADMET properties. Thus, the therapeutic potentials of glaucogenin C and hirundigenin can be explored for further in vitro and in vivo studies.
Serum checkpoint molecules in patients with IgG4-related disease (IgG4-RD)
Authors: Matsumoto Haruki , Fujita Yuya , Matsuoka Naoki , Temmoku Jumpei , Furuya-Yashiro Makiko , Asano Tomoyuki , Sato Shuzo , Watanabe Hiroshi , Suzuki Eiji , Tsuji Sosuke , Fukui Shoichi , Umeda Masataka , Iwamoto Naoki , Kawakami Atsushi , Migita Kiyoshi
Published: March 2021

Background

Immunoglobulin G4-related disease (IgG4-RD) is characterized by increased serum IgG4 concentration and infiltration of IgG4+ plasma cells in the affected organs. The present study aimed to characterize the serum levels of coinhibitory checkpoint molecule, T cell immunoglobulin and mucin-containing-molecule-3 (TIM-3), and its ligand, galectin-9 (Gal-9), among IgG4-related disease in patients with IgG4-RD patients with various organ involvements.
Methods

Serum samples were collected from untreated 59 patients with IgG4-RD, 116 patients with rheumatoid arthritis, and 37 healthy controls. Patients with IgG4-RD (n = 57) were subdivided into those with visceral involvement (n = 38) and those without visceral involvement (n = 21). Serum levels of Gal-9 and soluble TIM-3 (sTIM-3) were determined using enzyme-linked immunosorbent assay (ELISA). Results were compared with the clinical phenotypes of IgG4-RD.
Results

In untreated patients with IgG4-RD, serum levels of Gal-9 and sTIM-3 were significantly higher than in RA patients as well as in healthy controls. There were significant correlations between serum levels of Gal-9 or sTIM-3 and serum levels of IgG, BAFF, or sIL-2R. However, there was no significant correlation between the serum levels of Gal-9 or sTIM-3 and serum IgG4 concentrations. Serum levels of sTIM-3 were significantly higher in a subset of patients with visceral involvements than in those without visceral involvements. However, there was no significant difference in the serum levels of Gal-9 between IgG4-RD patients with and without visceral involvements. Although both, Gal-9 and sTIM-3 were elevated in untreated IgG4-RD patients, and the levels of these checkpoint molecules remained unchanged after steroid therapy.
Conclusion

Serum levels of Ga-9 and sTIM-3 were significantly elevated in untreated patients with IgG-RD. Furthermore, serum levels of sTIM-3 were significantly higher in IgG4-RD patients with visceral involvements. These checkpoint molecules could be a potentially useful biomarker for IgG4-RD and for assessing the clinical phenotypes of IgG4-RD.
Climate change impacts the protective effect of forests: A case study in Switzerland
Authors: Moos Christine , Guisan Antoine , Randin Christophe F. , Lischke Heike
Published: March 2021

In steep terrain, forests play an important role as natural means of protection against natural hazards, such as rockfall. Due to climate warming, significant changes in the protection service of these forests have to be expected in future. Shifts of current to more drought adapted species may result in temporary or even irreversible losses in the risk reduction provided by these forests. In this study, we assessed how the protective effect against rockfall of a protection forest in the western part of the Valais in the Swiss Alps may change in future, by combining dynamic forest modelling with a quantitative risk analysis. Current and future forest development was modelled with the spatially explicit forest model TreeMig for a moderate (RCP4.5) and an extreme (RCP8.5) climate change scenario. The simulated forest scenarios were compared to ground-truth data from the current forest complex. We quantified the protective effect of the different forest scenarios based on the reduction of rockfall risk for people and infrastructure at the bottom of the slope. Rockfall risk was calculated on the basis of three-dimensional rockfall simulations. The forest simulations predicted a clear decrease in basal area of most of the currently present species in future. The forest turned into a Q. pubescens dominated forest, for both climate scenarios, and mixed with P. sylvestris in RCP4.5. F. sylvatica completely disappeared in RCP8.5. With climate warming, a clear increase in risk is expected for both climate change scenarios. In the long-term (> 100 years), a stabilization of risk, or even a slight decline may be expected due to an increase in biomass of the trees. The results of this study further indicate that regular forest interventions may promote regeneration and thus accelerate the shift in species distribution. Future research should address the long-term effect of different forest management strategies on the protection service of forests under climate change.
Multiparametric MRI and 18F-DCFPyL PET/CT for detection of locally recurrent prostate cancer after low dose rate brachytherapy
Authors: Walker Stephanie M. , Fernandez Martina , Roy Soumyajit , Mena Esther , Sackett Jonathan , Mease Ronnie , Merino Maria , Pomper Martin , Salerno Kilian , Schott Erica , Wood Bradford , Pinto Peter , Lindenberg Liza , Choyke Peter , Citrin Deborah , Turkbey Baris
Published: March 2021

Background and purpose: Both multiparametric magnetic resonance imaging (mpMRI) and prostate specific membrane antigen (PSMA)-targeting positron emission tomography (PET) imaging have shown promise in early localization of prostate cancer (PCa) recurrence after primary external beam radiotherapy. Detecting recurrence after brachytherapy for PCa using MRI is significantly hampered by susceptibility artifacts secondary to brachy seeds. Here, we compare the efficacy of 18F-DCFPyL (2-(3-{1-carboxy-5-[(6-18F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid) PET/CT versus mpMRI for detecting sites of local recurrence after low dose rate (LDR) brachytherapy for prostate cancer.Materials and methods: A total of 155 patients with a history of recurrent PCa who underwent mpMRI at 3 Tesla and 18F-DCFPyL PET/CT were retrospectively reviewed. Patients who underwent LDR brachytherapy for PCa and had subsequent biochemical recurrence (BCR) followed by mpMRI and 18F-DCFPyL PET/CT were included in this study. mpMRI was performed on a 3T scanner with endorectal and surface coils and images were prospectively read by a single expert radiologist. The 18F-DCFPyL PET/CT scan was prospectively interpreted by two nuclear medicine physicians. Patients underwent targeted biopsy when deemed clinically necessary and specimens were interpreted by an expert GU pathologist. Positivity rates (PR) from mpMRI and 18F-DCFPyL PET/CT were compared, and pathology results were used to calculate the positive predictive value (PPV) of each imaging modality for detecting PCa recurrence.Results: 15 patients who underwent LDR brachytherapy and had subsequent biochemical failure were imaged with mpMRI and 18F-DCFPyL PET/CT. 18 non-lymph node lesions were identified on at least one imaging modality. The PR for detection of intraprostatic lesions was 60% (9/15) for both PET/CT and mpMRI, with 3 prostate lesions detected by only one modality. 18F-DCFPyL PET/CT identified pelvic and extra-pelvic lymph nodes in 8 (53%) patients, while mpMRI noted positive lymph node findings in only 2 (13%) patients. A total of 15 lesions corresponding to 9 patients were targeted for biopsy. The PPV of 18F-DCFPyL PET/CT and mpMRI for the detection of local recurrence were 84.6% and 71.4%, respectively. For the detection of intraprostatic lesions, 18F-DCFPyL PET/CT and mpMRI had a PPV of 87.5% and 71.4%, respectively. Conclusion: This case series analysis suggests that 18F-DCFPyL PET/CT may detect local and regional recurrent PCa after LDR brachytherapy at a higher rate than mpMRI and that it has the potential to detect suspicious pelvic lymph nodes at a much higher rate. Further studies are needed to validate these findings in larger cohorts.
Investigation of in Vitro Culturing Method for Ascaris lumbricoides Eggs in Laboratory: From Soil to Bench.
Authors: Nisha Mehru , Ghozi Athira Mohd , Davamani Fabian
Published: March 2021

Objective: Ascaris lumbricoides eggs are naturally available in contaminated soil and embryonated eggs are the source of Ascariasis infection to human. Investigation of in vitro culturing of Ascaris eggs in laboratory in not routinely reported in the literature. Hence, this study was carried out to investigate a simple method on in vitro culturing method for Ascaris lumbricoides eggs isolated from soil samples from an indigenous village in Malaysia.Results: Four stages of Ascaris lumbricoides eggs from the first-cell stage until the fourth stage were obtained. At the embryonation stage, the larvae of Ascaris worm was observed indicating survival of the eggs under an acidic environment.
Câncer de língua x trauma crônico e xerostomia: há relação?
Authors: Souza Yamille De Lima , Pinheiro Tiago Novaes , Cabral Lioney Nobre
Published: March 2021

O carcinoma espinocelular (CEC) é a neoplasia maligna mais comum da cavidade oral, sendo seus agentes etiológicos principais: o álcool, tabaco e o Papilomavirus Humano (HPV) de alto risco, porém, existem outras possibilidades etiopatogênicas ainda não amiudadas pela ciência. Este trabalho relata caso de paciente do gênero feminino, 48 anos, não tabagista, não etilista e sem sinal de infecção pelo vírus HPV, com queixa de lesão nodular em ventre lingual. Relatou hábito de “chupar a língua” desde tenra idade, boca seca e ardência bucal há alguns meses e, ao exame físico, apresentou ordenha negativa das glândulas parótidas, baixa coleta nas sublinguais e submandibulares. Apresentava sinais de comprometimento muscular cervical, massetérico e, por conseguinte, bucinatório, condição que pode concorrer fisicamente para estenose do ducto parotídeo e redução da secreção parotídea. Após diagnóstico de CEC, a paciente foi submetida a tratamento cirúrgico, radio e quimioterápico. Para o controle do hábito parafuncional, provavelmente relacionado à lesão que evoluiu para o CEC, foram realizados: uso de dispositivo interoclusal, fisioterapia e crioterapia com prescrição de saliva artificial e creme reparador para as lesões mucosas, decorrentes da hipo/assialia. Consideramos que a associação do trauma crônico, fator modificador clássico, resultante da atividade parafuncional e a redução do fluxo salivar promovida- entre outras razões orgânicas primárias, prévias ao tratamento radio e quimioterápico- pelo potencial estreitamento do ducto de Stenon em razão da disfunção mastigatória, como promotora da perda de homeostasia local e não controle de iniciadores endógenos e/ou exógenos, concorreram para o desenvolvimento da condição neoplásica.
Fratura de mandíbula tratada através da técnica de Champy: relato de caso
Authors: Rodrigues Éwerton Daniel Rocha , Castro Carla Cecília Lira Pereira de , Melo Thalita Medeiros , Farias Alan Leandro de Carvalho , Brito Júnior Laurindo de Sousa
Published: March 2021

Os traumas faciais representam um dos mais importantes problemas de saúde pública. As fraturas mandibulares compõem grande parte das injúrias sofridas pelo complexo maxilomandibular neste panorama. A região mais acometida é o ângulo mandibular (AM), devido a sua área de seccção transversal e biomecânica, além da presença de terceiros molares. Este artigo visa relatar um caso clínico de fratura mandibular, evidenciando diagnóstico e terapêutica. O relato de caso trata-se de um paciente do gênero masculino, 19 anos de idade, que compareceu ao ambulatório do serviço de Cirurgia Bucomaxilofacial de um hospital público queixando-se de dor à mastigação e dificuldade de abertura bucal. Ao exame radiográfico foi identificada solução de continuidade na região de ângulo mandibular, confirmando a hipótese diagnóstica de fratura de mandíbula. O tratamento proposto foi de procedimento cirúrgico sob anestesia geral para osteossíntese através do método retratado por Champy, utilizando-se de acesso intrabucal na região da linha oblíqua externa e bloqueio maxilo-mandibular (BMM) transoperatório com parafusos, seguida a fixação com a utilização de uma placa do sistema 2.0mm e posterior remoção do BMM. O paciente foi acompanhado durante seis meses e mostrou resultado clínico satisfatório. Conclui-se que a técnica de Champy é um método eficaz de fixação interna de fraturas, pois reduz o tempo cirúrgico e a dissecção tecidual, diminuindo as chances de lesões nervosas e complicações pós-operatórias.
A doença periodontal como um fator de risco para o câncer de pâncreas
Authors: Santos Carla Graciele , Lucena João Marcos da Costa , Oliveira Ocimar Lopes de , Holanda Júlia Kiara da Nóbrega , Anjos Raline Mendonça dos , Sousa Aleson Pereira de , Oliveira Filho Abrahão Alves de
Published: March 2021

A neoplasia pancreática ganhou destaque por sua alta letalidade e perspectiva de aumento da incidência no mundo, sendo a doença periodontal apontada como um dos fatores de risco para o desenvolvimento dessa patologia. Os patógenos encontrados na doença periodontal, como a Porphyromonas gingivalis e a Helicobacter pylori desencadeiam uma resposta inflamatória no hospedeiro que podem promover a carcinogênese pancreática. A resposta condicionada pelos agentes microbianos da doença periodontal, resulta no aumento de marcadores inflamatórios que estão expressos no câncer de pâncreas. De tal modo, esta pesquisa teve como intuito realizar uma revisão de literatura narrativa de estudos que correlacionam o câncer de pâncreas com a Doença Periodontal, tendo as plataformas Google Acadêmico e Scielo (Scientific Eletronic Library Online) como fonte de pesquisa, utilizando os seguintes descritores: “Câncer”, “Câncer de pâncreas” e “Doença periodontal”, durante os meses de Maio e Julho do ano de 2020. Os artigos selecionados foram do ano de 2003 ao ano de 2019. A realização de mais pesquisas sobre essa correlação se faz necessária, para que haja esclarecimento sobre a ligação entre essas doenças.
Potencial bioativo dos flavonoides vitexina, tilirosideo e 5,7-dihidroxi-3,8,4'-trimetoxi no tratamento de doenças crônicas e neoplasias do sistema gastrointestinal e excretor
Authors: Sousa Aleson Pereira de , Fernandes Diégina Araújo , Ferreira Maria Denise Leite , Cordeiro Laísa Vilar , Souza Helivaldo Diógenes da Silva , Souza Maria de Fátima Vanderlei de , Pessoa Hilzeth de Luna Freire , Oliveira Filho Abrahão Alves de , Sá Rita de Cássia da Silveira e
Published: March 2021

As doenças crônicas representam o principal grupo de doenças com elevados índices de mortalidade. Dessa forma, a utilização de plantas medicinais por adultos no tratamento de enfermidades ou amenização de seus sintomas é uma prática alternativa que vem sendo adotada mundialmente. O avanço científico e a modernização contribuem substancialmente para descoberta de substâncias naturais para produção de novos fármacos, com uma grande possibilidade de terem menor grau de toxicidade. Algumas dessas plantas são ricas em moléculas dotadas de potencial biotecnológico, como os flavonoides. O presente estudo avaliou o perfil bioativo in silico de três flavonoides: tilirosídeo (Kaempferol-3-O-β-D-(6”-Ep-coumaril) glucopiranosideo), Pg-1 (5,7-dihidroxi-3,8,4'-trimetoxi) e vitexina (5,7,4'-trihidroxiflavona-8-C-β-glucopiranosideo). Foi abordada a ação preditiva antineoplásica em órgãos do sistema gastrointestinal e urinário e a atividade protetora contra doenças crônicas (diabetes, hipertensão, catarata, osteoporose, hipercolesterolemia, disfunção de tireoide e doenças renais). O estudo demonstrou que a vitexina apresentou efeito antidiabetes (tipo II) e antihipercolesterolemia; o tilirosideo, atividade antidiabetes (tipo I), antihipercolesterolemia, antihipóxico, antinefrítico e antiosteoporótico, e o Pg-1, ação anticatarata, anti-hipertensiva e antitireoidiana. A avaliação da probabilidade do potencial antineoplásico mostrou que a vitexina possui melhor potencial anticâncer no pâncreas, estômago, bexiga e rim, e efeito anti - Helicobacter pylori. O Pg-1 apresentou maior atividade anticâncer no cólon e na região cólon-retal. O tilirosideo, apesar de exibir menor efeito em relação às demais substâncias, evidenciou atividade satisfatória anticâncer pancreática e cólon-retal. Portanto, estas moléculas podem tornar-se importantes candidatas a fármacos naturais como recurso terapêutico de combate a doenças crônicas e ao câncer do sistema gastrointestinal e urinário.
An In Vitro–Ex Vitro Micropropagation System for Hemp
Authors: Lubell-Brand Jessica D. , Kurtz Lauren E. , Brand Mark H.
Published: March 2021

Hyperhydricity of shoots initiated in vitro, poor shoot extension, inability of shoot cultures to maintain good growth over an extended time, and unsuccessful ex vitro rooting have limited the development of a commercial scale micropropagation system for hemp (Cannabis sativa). We present a culture initiation method that prevents shoot hyperhydricity using vented-lid vessels with 0.2-µm pores and medium containing agar at 1% (w/v). To optimize shoot multiplication in vitro, a control medium (medium A) and four treatment media (medium B, C, D, and E), with varying inorganic nutrients and vitamins were tested. Control medium A consisted of 1× Murashige and Skoog (MS) with vitamins plus 3% (w/v) sucrose, 0.5 mg·L−1 metatopolin, 0.1 mg·L−1 gibberellic acid, and 0.8% agar (w/v) at pH 5.7. The four treatment media differed from the control medium as follows: medium B, 2.5× MS with vitamins; medium C, 1× MS with vitamins plus added mesos [calcium chloride (anhydrous), magnesium sulfate (anhydrous), and potassium phosphate (monobasic) nutrients]; medium D, 1× MS with vitamins plus added vitamins; and medium E, 1× MS with vitamins plus added mesos and vitamins. Medium C and medium E produced more microcuttings than the control at 6 weeks after the initial subculture with shoot multiplication media and all other treatments at 9 and 12 weeks. Shoots grown on these two media displayed optimal extension and leaf lamina development; however, they exhibited slight chlorosis by 12 weeks after subculture with shoot multiplication media. In a separate experiment, medium E was supplemented with ammonium nitrate at 0, 500, 1000, or 1500 mg·L−1, and cultures grown with 500 mg·L−1 produced the most microcuttings and exhibited the best combination of shoot extension and leaf lamina development. We provide a method of prerooting microshoots in vitro that has resulted in 75% to 100% rooting ex vitro in rockwool. Using 10 recently micropropagated plants, ≈300 retip cuttings (cuttings taken from new shoots from recently micropropagated plants) were harvested over 10 weeks. The average weekly rooting was more than 90%. Retipping can produce nine-times as many plants in a similar amount of floor space as stem cuttings derived from traditional stock mother plants. The micropropagation/retipping method proposed can be a more efficient way to generate clonal liner plants for commercial-scale production.
Basilaphelenchus hyrcanus n. sp. (Rhabditida: Tylaphelenchinae) associated with bark of a beech tree (Fagus orientalis Lipsky) from northern Iran
Authors: Golhasan Behrouz , Miraeiz Esmaeil , Tanha maafi Zahra , Heydari Ramin
Published: March 2021

Basilaphelenchus hyrcanus n. sp., the sixth species of the newly established genus was isolated during a nematode survey associated with bark samples of beech tree in northern Iran, which differs from the other species by body size, stylet length, metacorpus structure, and tail characters of both genders. The new species is also characterized by elevated cephalic region with sclerotised vestibule, posteriorly directed stylet knobs, well-developed metacorpus filling corresponding body region, position of excretory pore at the level of base of metacarpus, length of post uterine sac by 38–60 μm long, conoid elongate tail by sharp to finely rounded tip in female. Based upon the morphological characteristics and phylogenetic analyses of partial 18 S and D2-D3 28 S rDNA segments, the new species mostly resembles B. magnabulbus. However, B. hyrcanus n. sp. is clearly different from this species by having a longer stylet, different position of the excretory pore, a different male tail tip characters and 4.4 and 13.2% sequence divergences in 18 S and D2-D3 28 S, respectively.
The influence of e-conferences and e-meetings on increasing communication skills among leaders in Jordanian mining and manufacturing industries
Authors: Ahmad Abdel-Qader Mohd
Published: March 2021

This study aims to examine the influence of e-communication (e-meetings and e-conferences) on the communication skills of managers and leaders (decision making, problem solving, consistency, productivity and better work flow). Quantitative approach was employed to achieve the aim; 150 managers and leaders responded to a self-administered questionnaire, which was tackled later using SPSS.The results of the study confirmed an undeniable influence of e-communications on communication skills of managers and leaders within Jordanian mining and manufacturing industries; the most influenced variable was decision-making process associated with the real-time data that e-communication means can provide to decision makers (data, information, figures and numbers), which facilitated a faster ability to take decisions and avoid risks among organizations. The study also demonstrated that electronic meetings and conferences are based on transmitting voice over internet protocol (VoIP), which allows voice to be transmitted over the Internet, which is key to facilitating real-time electronic meetings. The study recommended adopting more electronic means of communication as an approach to avoid loss of time and efforts in face-to-face communication.
Strategizing of Kuzbass Human Capacity
Authors: Novikova I. V. , Abrosova O. E. , Boiko K. V. , Boksgorn A. A. , Bochancev A. S. , Busygin S. Yu. , Ganeev A. F. , Ermolaev A. N. , Dudovceva Yu. V. , Zadorozhnaya G. V. , Isakova L. E. , Karpov O. N. , Kilina I. A. , Konovalov A. B. , Kochergin D. , Krasnoshlykova O. G. , Kuz'mina G. I. , Latyshenko E. P. , Leuhova M. G. , Lysyh O. B. , Meleshkin D. N. , Morozova Elena , Nesterenko O. A. , Ovchinnikov V. , Osipova N. V. , Pahomova E. A. , Pokrovskaya M. A. , Polichuk E. V. , Prosekov Aleksander , P'yanov A. E. , Cherveva O. P.
Published: March 2021

The collective monograph of the Library "Kuzbass Strategy" presents the main factors that shape the human potential of Kuzbass. The main historical stages of the development of labor resources in the region are considered. The results of the analysis of the development of the education system, health care, culture, sports, social sphere, entrepreneurship and employment of the Kuzbass population are presented. The main strategic priorities for the development of the human potential of Kuzbass to 2035 are outlined.
The education system of a Russian region: a comprehensive analysis
Authors: Aleshkovskiy I. A. , Belyaeva G. F. , Gasparishvili A. T. , Ziskin K. E. , Ionov A. A. , Kruhmaleva O. V. , Lysenko V. V. , Malieva N. A. , Molchanov I. N. , Moteva A. I. , Pakhomova E. , Savina N. E. , Himilonova I. V.
Published: March 2021

The monograph was prepared within a project of the Vernadsky-Kuzbass Scientific and Educational Consortium. It presents a comprehensive study of the 2010–2018 education system of Kuzbass carried out by the Center for Education Development Strategy at M.V. Lomonosov Moscow State University. The study compared the education systems in Kuzbass and other regions of Russia, drawing on related statistical data and reference materials. It also involved sociological surveys to identify the attitude of educators at three levels – general secondary, secondary vocational and tertiary – to the development of the regional education system.
The authors’ conclusions and recommendations became a basis for the Strategy of Education Development in Kuzbass.
The book is addressed to professionals working in education, management and sociology of education, as well as those with a general interest in the problems and trends of modern education.
Strategizing of Kuzbass Region Economic and Investing Development
Authors: Kvint Vladimir , Alimuradov M. K. , Astapov K. L. , Alekseev G. F. , Bagaev D. V. , Boksgorn A. A. , Bondarev N. S. , Veys E. A. , Venger K. G. , Vladimirov D. Ya. , Vlasyuk L. I. , Gavrilina D. N. , Ganieva I. A. , Egorova A. I. , Kosinskiy P. , Kuznecova K. V. , Maslov A. , Midov A. Z. , Myaskov A. V. , Nikitenko S. M. , Pleshkan' P. Yu. , Sasaev N. I. , Sizemov D. N. , Tkachenko I. S. , Tkachenko S. N. , Haritonov A. V. , Habekova M. K. , Khvorostyanaya A. S. , Chernoskutov D. Yu. , Chotua I. Z. , Shevchuk A. V.
Published: March 2021

The collective monograph "Strategizing of Kuzbass Region Economic and Investing Development" examines strategic initiatives for Kuzbass region transformation up to 2035, associated with the development of traditional and the formation of new industries, the financial markets and foreign economic relations, aimed at improving Kuzbass people’ quality of life.
Retos del profesor universitario: un rol que se re-configura permanentemente
Authors: Martínez Delgado Cecilia María , Mejía Pérez Paula Natalia , Bano Jaramillo Iván David , Echeverri Escobar José Ignacio , Vélez Jaramillo Luis Fernando , Vélez Ríos Julián Emilio , Restrepo Restrepo Manuel
Published: March 2021

La profesión docente constituye un desafío permanente para quienes la ejercemos, debido a que socialmente es una de las profesiones menos valoradas. Sin embargo, en ella recae la obligación de formar los ciudadanos del futuro, en cualquiera de las épocas en las que se ejerza. Se presenta una aproximación al deber ser del profesor universitario, teniendo en cuenta que se configura y re-configura en una labor de importancia, asociada a la calidad educativa. Se plantean no solo valores que se deben tener para este ejercicio, sino también los retos que el mundo actual en constante cambio le asigna, para la formación integral de los futuros profesionales. Esta reflexión se realizó a partir de conversaciones académicas de algunos integrantes de la comunidad educativa de un área de la salud.
Does Innovation Affect Company Performance? Exploring the Mediation Effects of Management Accounting Information Systems
Authors: Miftah Desrir , Julina
Published: March 2021

This study attempt to determine the direct effect of innovation on company performance and its indirect effect through Management Accounting Information Systems (MAIS) as an mediating/intervening variable. Samples were managers in the manufacturing industry that produces Crude Palm Oil (CPO) operating in Riau Province. Data collected through questionnaires and processed using SEM-PLS. The results found that innovation affects firm performance. Management Accounting Information Systems mediates the effect of innovation and firm performance. Research on MAIS as intervening variable in the palm oil industry was first carried out especially in Indonesia. Innovations made by company through a good Management Accounting Information System will improve the performance of CPO producing company
Climate change and water insecurity in rural uMkhanyakude District Municipality: an assessment of coping strategies for rural South Africa
Authors: Patrick Hosea Olayiwola
Published: March 2021

The vulnerability of Africa to climate change extremes and eventual impacts is extremely high due to the weak coping strategies prevalent in the continent. The peculiarity of South Africa to these vulnerabilities, especially for water security, is an issue of socioeconomic and policy issue. Based on the premises of human security, the study assesses the coping strategies of rural communities in South Africa, focusing on uMkhanyakude District Municipality, KwaZulu-Natal province, given the effects of climate change-induced water scarcity on the area. The study employed a multilayered descriptive mixed method triangulation approach. It focused specifically on the connection between water and climate change and the adopted everyday vertical and horizontal coping strategies. The findings revealed a strong correlation between the behavioral and traditional coping strategies in the study area, water depletion/scarcity, and climate change. It also showed that government institutions are reactionary in their response to climate change-induced impacts. The study, therefore, recommends a pre-resilience mechanism that makes institutions and individuals proactive rather than adopting a reactionary post-resilience strategy in response to the effects of climate change-induced water security.
Assessment of basin-wise future agricultural drought status across India under changing climate
Authors: Suman Mayank , Maity Rajib
Published: March 2021

Most of the existing studies on meteorological drought suggest more intense and frequent drought events due to changing climate. However, basin-scale assessment of future agricultural drought is lacking due to many reasons. In this study, the intensity and frequency of future agricultural drought (characterized by the Standardized Soil Moisture Index, SSMI) for 226 sub-basins across India are analyzed, and vulnerable basins are identified. The prediction of the future agricultural drought status is achieved using the wavelet-based drought temporal consequence modeling of meteorological drought with the best performing bias-corrected Coordinated Regional Downscaling Experiment (CORDEX) simulations, selected by Multi-Criteria Decision-Making frameworks. This study reveals a geographically contrasting change in future agricultural drought that indicates more intense agricultural drought in north, north-east, and central India as compared with south India. The area under drought is also expected to increase, and about 20 and 50% of the Indian mainland is expected to suffer from extreme (SSMI ≤ −2) and moderate (SSMI ≤ −1) agricultural drought conditions by the end of this century. Sub-basins lying in north and central India are expected to have a longer time under drought conditions. Thus, the findings of this study will be useful for future planning and preparedness against agricultural productivity.
Parameters optimization for eutrophic lake water treatment by a novel process of iron-carbon micro-electrolysis coupled with catalytic ozonation using response surface methodology
Authors: Jiang Shanqing , Cao Yu , Han Pei , Zhang Yanan , Zhang Hankun , Zhang Qiuya , Xu Xia , Zhou Yuanyuan , Wang Liping
Published: March 2021

A novel process of iron-carbon micro-electrolysis (ICME) coupled with catalytic ozonation (CO) for treatment of eutrophic lake water was developed. A series of batch experiments with ICME alone and CO alone was designed to investigate the effects of process parameters, such as initial pH, dose of Fe-C, time of micro-electrolysis, ozone flux, dose of TiO2/activated carbon (TiO2/AC), and time of ozonation, on the removal rates of total nitrogen (TN), total phosphorus (TP), CODMn and Chl-a. The process parameters were optimized using response surface methodology. The results showed that initial pH, dose of Fe-C and ozone flux had significant effects on removal of TN, TP, CODMn and Chl-a. Within the range of selected operating conditions, the optimized values of initial pH, dose of Fe-C, time of micro-electrolysis, ozone flux, dose of TiO2/AC, and time of ozonation were 3.8, 13.7 g/L, 29.6 min, 3.19 L/min, 294.74 mg/L and 106.73 min, respectively. Furthermore, ICME alone had significant advantages in TP and CODMn removal and CO alone favored TN and Chl-a. Under the optimal process conditions, the final removal rates of TN, TP, CODMn, and Chl-a by the hybrid ICME-CO process reached 75.33%, 86.29%, 94.42% and 97.57%, respectively. The present research provides a new alternative technology with promise for treatment of eutrophic lake water.
Characteristics of the extracellular products of pure oxygen aerated activated sludge in batch mode
Authors: He Jia-Ying , Zhang Hong-Ling , Wang Hong , Hu Ya-Qi , Zhang Yong
Published: March 2021

The effects of pure oxygen aeration on compositional characteristics of soluble microbial products (SMP) and extracellular polymeric substances (EPS) of the activated sludge acclimated in a sequential batch reactor (SBR) were explored in batch mode. The structure of the extracellular products would change with different aeration methods or aeration rates. The proportion of SMP of most oxygen aerated sludge was less than 10%, while that in air aerated sludge was as high as 30–40%. The proportion of TB-EPS decreased from 56.95% to 30.63%, and the proportion of LB-EPS increased obviously with the increase of oxygen aeration rate. The contents of the protein (PN) and the polysaccharide (PS) of extracellular products with oxygen aeration were significantly different, and the PN was much higher than PS (p < 0.05). The zeta potential of each component in activated sludge was negative, gradually decreasing with the progress of biological treatment. The fluorescence peaks in SMP, LB-EPS and TB-EPS with pure oxygen aeration were attributed to tryptophan PN-like and humic acid-like fractions. The results showed that the proportion of the components in the extracellular products could be regulated by adjusting the aeration rate and aeration mode, so as to optimize the treatment process of activated sludge.
Role of Aberrant Lipid Metabolism of Cancer Stem Cells in Cancer Progression
Authors: Zhou Juan , Zhao Jing , Su Chunxia
Published: March 2021

Cancer stem cells (CSCs) represent a small population of cancer cells that are able to
self-renew and initiate tumors, which undergo epigenetic, epithelial-mesenchymal, immunological,
and metabolic reprogramming to adapt to the tumor microenvironment as well as survive host defense
or therapeutic insults. The metabolic reprogramming that accompanies cancer onset is known
to be critical for the disease pathogenesis. A coordinated dysregulation of lipid metabolism is observed
in nearly all cancer types. In addition to fulfilling the basic requirements of structural lipids
for membrane synthesis, lipids function importantly as signaling molecules and contribute to energy
homeostasis. In this review, we summarize the current progress in the attractive research field
of aberrant lipid metabolism regarding CSCs in cancer progression, which provides insights into
therapeutic agents targeting CSCs based upon their modulation of lipid metabolism.
Novel Study Designs in Precision Medicine – Basket, Umbrella and Platform
Trials
Authors: Kesari Harshad V. , Ravi Renju
Published: March 2021

:

The concept of ‘one size fits all’ - one treatment for patients with a particular disease,
seems to be outdated. The advent of precision medicine has prompted profound changes in clinical
research and it allows researchers to predict more accurately, the prevention and treatment strategies
for a specific disease population. Novel study designs are, therefore, essential to establish safe
and effective personalized medicine. Basket, umbrella and platform trial designs (collectively referred
to as master protocols) are biomarker enrichment designs that allow for testing more than
one hypotheses within a protocol, thus accelerating drug development. These trial designs tailor intervention
strategies based on patient’s risk factor(s) that can help predict whether they will respond
to a specific treatment. Basket trials evaluate therapy for various diseases that share a common
molecular alteration, while umbrella trials evaluate multiple targeted therapies for a single disease
that is stratified into subgroups based on different molecular alterations/ risk factors. These designs
are complex and their major limitations stem from the fact that it would be inappropriate to
completely replace histological typing with molecular profiling alone. However, in the upcoming
decades, these trial designs are likely to gain popularity and improve the efficiency of clinical research.
This article briefly overviews the characteristics of master protocol designs with examples
of completed and ongoing clinical trials utilizing these study designs.
Konsep Pendidikan Islam Holistik Prof. Dr. Tuty Alawiyah serta relevansinya di Era Millenium
Authors: Ulya Amaliy Atul , Ulya Amaliy Atul
Published: March 2021

Prof. Dr. Tuty Awawiyah is a female scholar as well as educational thinker  who succeded establishing and managing Pesantren-based schools starting form kindergarten, the elementary school,  junior high school, the senior high school until the college. The Purpose of this paper is to add insight and treasure about the concept of holistic Islamic education of Prof. Dr. Tuty Alawiyah and its relevance in the Millenium Era. Based on reseach and literature review that have been done, Islamic holistic education can be interpreted as education that is able to answer the problems of education faced in the word of education di the millennium era, for Islamic holistic education  is education that shapes something in a whole way, therefore it becomes a very large unity that any other exithing combination. In can be concluded that, some holictic Islamic Education concept form Prof. Dr Tuty Alawiyah are very relevant so it needs to be discussed and they will appropriate as a quide in the millennium Era.

            Keyword: Tuty Alawiyah, Education, Millennium Era.
WeChat as a Platform for Problem-Based Learning Among Hematological Postgraduates: Feasibility and Acceptability Study
Authors: Luo Ping , Pang Wenwen , Wang Yingying , Liu Minghui , Zhou Shu , Liu Shuai , Zhang Xian , Liu Li , Liu Yanan , Zhou Fuling
Published: March 2021

Background

Hematological medicine is a practical discipline that is difficult to study. Problem-based learning (PBL) is an innovative student-centered teaching method wherein students define their own learning objectives from clinically based problems. Considering that WeChat is the most popular communication app in China, we selected it as a new platform for online PBL to reduce the limitations of traditional PBL in hematology teaching.

Objective

This study aims to explore a new pedagogical method called WeChat-PBL, which is based on real micro clinical cases for postgraduates majoring in hematology and to demonstrate its feasibility and acceptability.

Methods

A total of 48 hematological postgraduates and 7 tutors participated in this study. We divided the participants into 7 groups where students can learn theoretical knowledge. After each course, the members of each group were required to complete in-class quizzes. Moreover, the students and tutors were required to fill out periodic (after each class) and overall (after each semester) evaluations.

Results

A total of 8 micro clinical cases were presented in WeChat-PBL. The average quiz score for acute myelogenous leukemia, chronic myeloid leukemia, multiple myeloma, acute promyelocytic leukemia, and lymphoma were 89.0%, 86.0%, 83.4%, 88.8%, and 77.5%, respectively. Periodic evaluations showed that both students and tutors were satisfied with the process of WeChat-PBL. The overall evaluation results showed that WeChat-PBL was able to positively impact the learning experiences of hematological postgraduates.

Conclusions

Our results indicate the feasibility and acceptability of the WeChat-PBL teaching method for postgraduates majoring in hematology.
Emotional Reactions to Cybersecurity Breach Situations: Scenario-Based Survey Study
Authors: Budimir Sanja , Fontaine Johnny R J , Huijts Nicole M A , Haans Antal , Loukas George , Roesch Etienne B
Published: March 2021

Background

With the ever-expanding interconnectedness of the internet and especially with the recent development of the Internet of Things, people are increasingly at risk for cybersecurity breaches that can have far-reaching consequences for their personal and professional lives, with psychological and mental health ramifications.

Objective

We aimed to identify the dimensional structure of emotion processes triggered by one of the most emblematic scenarios of cybersecurity breach, the hacking of one’s smart security camera, and explore which personality characteristics systematically relate to these emotion dimensions.

Methods

A total of 902 participants from the United Kingdom and the Netherlands reported their emotion processes triggered by a cybersecurity breach scenario. Moreover, they reported on their Big Five personality traits, as well as on key indicators for resilient, overcontrolling (internalizing problems), and undercontrolling (aggression) personality types.

Results

Principal component analyses revealed a clear 3-dimensional structure of emotion processes: emotional intensity, proactive versus fight/flight reactions, and affective versus cognitive/motivational reactions. Regression analyses revealed that more internalizing problems (β=.33, P<.001), resilience (β=.22, P<.001), and agreeableness (β=.12, P<.001) and less emotional stability (β=–.25, P<.001) have significant predictive value for higher emotional intensity. More internalizing problems (β=.26, P<.001), aggression (β=.25, P<.001), and extraversion (β=.07, P=.01) and less resilience (β=–.19, P<.001), agreeableness (β=–.34, P<.001), consciousness (β=–.19, P<.001), and openness (β=–.22, P<.001) have significant predictive value for comparatively more fight/flight than proactive reactions. Less internalizing problems (β=–.32, P<.001) and more emotional stability (β=.14, P<.001) and aggression (β=.13, P<.001) have significant predictive value for a comparatively higher salience for cognitive/motivational than affective reactions.

Conclusions

To adequately describe the emotion processes triggered by a cybersecurity breach, two more dimensions are needed over and above the general negative affectivity dimension. This multidimensional structure is further supported by the differential relationships of the emotion dimensions with personality characteristics. The discovered emotion structure could be used for consistent predictions about who is at risk to develop long-term mental well-being issues due to a cybersecurity breach experience.