bluuebunny/crossref_metadata_2025 huggingface dataset:
METHOD OF FORECASTING PSYCHOGENIC LOSSES OF MILITARY PERSONNEL DURING COMBAT TASKS
Authors:   The National academy of hte National Guard of Ukraine, Batsamut V. , Prykhodko I. ,   The National academy of hte National Guard of Ukraine
Published: December 2022

The article presents a modern classification of total losses of personnel in a special period, clarified the content of irreversible, sanitary and psychogenic losses and proposed a methodology for forecasting psychogenic losses of servicemen of the security and defense sector of Ukraine when performing combat tasks in a special period. The basis of the developed methodology is the extrapolation method of forecasting theory based on trend models. To approximate the identified trends and extrapolate them to the future, the second-order polynomial is used in the methodology, which is able to describe changes in speed and acceleration that occur during the development of a dynamic process. In addition, the methodology uses a toolkit for discounting initial data, which makes it possible to give greater significance to the latest observations of a dynamic series in the event of sudden changes in the dynamic process. Conversely, if the dynamic series is free from sharp fluctuations, the formation of forecast estimates will be influenced by all elements of this series equally. Therefore, the forecaster has the opportunity to assess the dynamics of psychogenic losses that have occurred in a certain unit, military unit (unit), and adjust the forecasting tool (methodology) accordingly. The produced predictive assessment of psychogenic losses consists of point and interval estimates determined for a prescriptively established confidence probability value. To make predictions about the number of psychogenic losses, the technique uses real accumulated statistical data on such losses in a unit, military unit or unit over the past period of time. Due to this approach, the technique is universal and, therefore, can be used in any formation of the security and defense forces of Ukraine.
FUNCTIONING MODEL OF THE SYSTEM OF TECHNICAL SUPPORT OF SERVICE AND COMBAT ACTIONS GROUP OF THE NATIONAL GUARD OF UKRAINE
Authors:   The National academy of hte National Guard of Ukraine, Kaidalov R. , Adamchuk M. ,   The National academy of hte National Guard of Ukraine, Toryanik D. ,   The National academy of hte National Guard of Ukraine
Published: December 2022

The effectiveness of the performance of service and combat missions by the technical support grouping is a generalized defining functional property of the technical support system. This property is revealed through the category of the goal and is objectively expressed by the degree of achievement of the goal, provided that the technical support organization meets the basic requirements, the level of fulfillment of which will determine the efficiency of the technical support system. The main research concept for analyzing the effectiveness of performing tasks as intended is modeling. Therefore, there is a need to develop a model for the functioning of the technical support system for military operations of the National Guard of Ukraine. The basis for developing a model for the functioning of the technical support system is a systematic approach to studying the problems of technical support for the service and combat operations of the National Guard of Ukraine grouping, which makes it possible to determine the composition of the forces and means of technical support for the National Guard group of Ukraine in the area of service and combat missions. The study of the management processes of military organizational systems today is carried out using only mathematical modeling methods, but the use of mathematical decision-making methods with a full set of clear input data does not always help in solving the problem under conditions of natural uncertainty of the situation. Based on the analysis of the existing scientific and methodological apparatus for evaluating the effectiveness of the functioning of the technical support system of the National Guard of Ukraine grouping, the article proposes a model for the functioning of the technical support system for service and combat operations of the National Guard of Ukraine grouping. The proposed model, in contrast to the known ones, includes the methods of simulation and situational modeling, the expert method, the method of forming a rational system for the technical support of the grouping of the National Guard of Ukraine.
Development of yogurts with mixture of sheep and bovine milk: effect on chemical physical characteristics, protein profile and antioxidant activity
Authors: Trentin Micheli Mayara , Becker Alexandra Fabiola , Hanauer Dalana , Bianchi Andressa , Borges Ligia , Schogor Ana Luiza Bachmann , Rigo Elisandra
Published: December 2022

Yogurt is one of the most popular fermented dairy products and an excellent medium for new ingredients/food source. This study sought to evaluate and characterize bovine milk (BM) and sheep milk (SM) and yogurt made from bovine (BM) and sheep (SM) milk, and BM:SM mixture with the respective 100:0 fractions: 75:25, 50:50, 25:75 and 0:100, and evaluate their influence on physicochemical parameters, antioxidant, protein profile, microstructure and color analysis for yogurts. Yogurts with higher levels of acidity, protein, fat, total solids, ash and calcium were the ones made from SM.. Regarding the color attributes, all yogurts showed yellow-green characteristics after 21 days of storage by evaluating parameters a* and b*, with a predominance of bovine milk. The antioxidant profile showed a higher concentration at 100:0 and 0:100, but bovine milk has a higher DPPH (2,2-diphenyl-1-picrylhydrazyl) value, while yogurts maintained constant DPPH values ​​during storage, being higher at 0:100. Scanning electron microscopy (SEM) showed that BM (100:0) has a more compact structure, possibly due to the larger size of the fat particles and the lower protein concentration compared to SM (0:100). Sheep milk presented better nutritional value, showing its potential in the manufacture of products.
Lavender oil and its effectiveness in anxiety symptoms
Authors: Silva Ewelyn , Souza Thamyres Fernanda Moura Pedrosa
Published: December 2022

Studies prove that using aromatherapy with lavender oil generates reduction of anxiety, sedative, antidepressant, soothing, antispasmodic, analgesic and healing effects. A fact that occurs due to the inhibitory action of lavender on the hypothalamic-hypophysis-adrenal axis, which results in the reduction in the release of cortisol, the stress hormone. Promoting, on the other hand, the release of serotonin, generating a feeling of pleasure and well-being. Thus, the present study aimed, through an integrative literature review, to describe the effects of the use of lavender oil in the treatment of anxiety. The psychological effects of inhaling lavender oil occur through conscious perception, belief and expectation. Meanwhile, the pharmacological effects occur through the modulation of the cyclic activity of adenosine monophosphate (reduction of cyclic adenosine monophosphate results with sedation) and inhibition of glutamate binding (sedative effects). Thus, the use of oil is considered safe, except for rare allergic reactions, and can be beneficial in patients with anxiety and reduce the use of antipsychotic drugs.
A importância do cirurgião dentista na UTI: uma revisão de literatura
Authors: Bandeira Myrella , Knaak Flavia , Ribeiro Ana
Published: December 2022

Introdução: As unidades de terapia intensiva (UTI) são voltadas ao cuidado do paciente em estado crítico em todos os níveis assistenciais. Inserido neste âmbito, a ação do cirurgião-dentista habilitado nas UTIs é fundamental na qualidade de vida e na promoção de saúde dos pacientes internados, acontece assim uma diferenciação na assistência hospitalar prestada. Objetivo: Discutir a necessidade da presença e inclusão do cirurgião-dentista nas Unidades de Tratamento Intensivo frente a possíveis perigos relativos à higiene a que os pacientes estão expostos. Metodologia: Os trabalhos foram escolhidos criteriosamente obedecendo um fluxograma segundo os métodos de PRISMA. Os estudos foram selecionados de acordo com o que propõe o fluxograma PRISMA, este dividido em cinco etapas de avaliação e investigação: identificação, triagem, elegibilidade, inclusão e análise de dados. Resultados: Obteve-se um total de treze artigos publicados em periódicos nacionais e internacionais. Foram analisados os resultados dos respectivos autores em relação a pergunta norteadora do trabalho. Discussão: Os protocolos e falta de padronização são os maiores problemas detectados. A atuação ainda é bastante irregular, não há padronização na prestação de serviço. Outro ponto observado, talvez o principal, é em relação aos protocolos. Conclusão: Constatou-se que grande parte dos hospitais não possuem uma cultura de protocolos para cuidados bucais para pacientes em UTIs, em alguns hospitais nem se quer há protocolos e nem a presença de um cirurgião-dentista.
Custos de implantação e condução de gladíolo no sistema de plantio direto orgânico em Laranjeiras do Sul/PR
Authors: Lima Gabriel Silva de , Lima Claudia Simone Madruga , Leandrini Josimeire Aparecida , Oliveira Rivael de Jesus , Baranek Edemar Jose
Published: December 2022

O conhecimento dos aspectos econômicos é de suma importância para implantação de um projeto, com isso, na região sul do Brasil a floricultura comercial é recente, mas a atividade vem crescendo e obtendo dados expressivos durante os últimos cinco anos. Sendo asso, o cultivo comercial de gladíolo (Gladiolus x grandiflorus Hort.), na forma de plantio direto orgânico, apresenta estudos e dados técnicos escassos, havendo ainda carência de informações, como custos de implantação e os principais coeficientes técnicos, dificultando a análise mais precisa da possibilidade de implantação. O objetivo neste trabalho foi determinar os principais coeficientes técnicos, custos de implantação e condução de um hectare de gladíolos em sistema de plantio direto orgânico em Laranjeiras do Sul/PR. O estudo foi realizado no período de 2020/21 onde ocorreram consultas na literatura de todos os aspectos da cadeia produtiva do gladíolo como dados técnicos, tratos culturais e produção, dentre outros. Também foram coletadas informações com pesquisadores, além da instalação de um experimento a fim de validar o estudo realizado. Os custos totais de implantação e condução de um hectare de gladíolo atingiram R$ 235.895,529 cujos componentes mais significativos na composição dos custos foram os gastos com insumos, especialmente a aquisição de adubos orgânicos e bulbos. Já as operações mecanizadas e manuais resultaram em valores de baixa proporção no custo total, sendo a menor participação a dos “outros insumos”. Deste modo, conclui-se que a determinação dos custos de implantação e condução é de grande importância, visto que pode ser atraente para investidores e agricultores.
Análise de estruturas de academias ao ar livre em Teresina–PI
Authors: Paulo Beatriz Lima de Albuquerque , Marques Thallyson José Bernardino de Sousa , Silva Kácio dos Santos
Published: December 2022

Esta pesquisa consistiu em analisar estruturas de academias ao ar livre em Teresina–PI, discutindo a tentativa de compreender a atividade física nos parâmetros da promoção da saúde a partir de uma aproximação com academias ao ar livre em uma abordagem social, demográfica e das políticas públicas apresentando um quadro informativo sobre as partes que integram as academias no âmbito estrutural e informativo. A metodologia do presente artigo utiliza-se de uma pesquisa de campo, de abordagem quali-quantitativa, do tipo exploratória e descritiva. O estudo teve início no mapeamento das academias ao ar livre de Teresina-PI através dos dados disponibilizados pela Secretaria municipal de Esporte e Lazer (SEMEL), seguindo essa coleta de dados, foi questionado através de uma visita aos locais com um quadro confeccionado pelos autores para detalhar as AAL selecionadas aleatoriamente. A pesquisa revelou que as 5 academias catalogadas apresentaram uma estrutura adequada para a prática de atividade física, tendo em vista a boa conservação dos equipamentos e informações no quadro de orientação, porém, a ausência de profissionais aptos a orientar orientação é levada em consideração e a falta de acessibilidade no local para portadores de deficiências, considerando que a acessibilidade é um direito de todos. Conclui-se que as AAL disponibilizadas à população teresinense se encontram conservadas estruturalmente mediante os aparelhos oferecidos, apesar disso requer uma atenção no quesito acessibilidade e especialmente na ausência de profissionais de Educação Física capacitados atuando neste local, para assim a prática de atividade física orientada possa ser exercida como política pública.
Impacto do número crescente de casos de obesidade na saúde pública: uma revisão
Authors: Fernandes Nayumy Gonçalves , Costa Flávia Nunes
Published: December 2022

A obesidade pode ser definida como o acúmulo de gordura corporal em excesso a ponto de comprometer a saúde dos indivíduos acometidos por ela, além de ser fator de risco para o desenvolvimento de outras patologias como diabetes, dislipidemia, doenças cardiovasculares e respiratórias. Assim, o adoecimento da população acarreta gastos para saúde pública, uma vez que se faz necessário o uso de medicamentos e tratamentos. Nesse contexto, este trabalho tem como objetivo expor os perigos atribuídos a obesidade, bem como seu impacto na saúde pública analisando seus custos. Para tal, uma revisão integrativa da literatura foi realizada em um recorte temporal de 2018 a 2022, obtendo resultados que geraram discussão acerca da temática. Verificou-se que a crescente taxa de casos de obesidade se deve potencialmente a mudanças de hábitos alimentares ao longo dos anos, assim como o crescimento da indústria alimentícia e que, com esse aumento de casos, tem-se onerado o sistema público de saúde. Sendo assim, práticas de prevenção à doença, como adoção de bons hábitos alimentares, atividade física e educação nutricional são vistas como necessárias para diminuir tais custos na gestão pública.
Impacts of Different Processing Techniques on Chemical and Mineral Components of Wild-Grown Edible Mushroom (Lactarius semisanguifluus R. Heim & Leclair)
Authors: AYDIN Emine , GÜRBÜZ İsmail Bülent
Published: December 2022

Lactarius semisanguifluus R. Heim & Leclair (L. semisanguifluus) is one of the wild-grown edible mushroom types. Wild-grown edible mushrooms are widely consumed or sold by people in fresh form. However, due to the high respiration ratio and moisture content, the mushrooms lose their quality immediately after harvest. This causes their shelf life to be very short. For this reason, it is necessary to know the best storage conditions as well as its nutritional content. The objective of this study was to investigate the effects of different treatment techniques (drying, canning, and freezing) on the chemical components (dry matter, crude protein, crude fats, ash, and total carbohydrates) and the mineral matters (Na, K, Mg, Ca, P, Fe, Mn, Cu, and Zn) of the L. semisanguifluus. The results show that the moisture content varied between 8.86% to 90.43% (w/w) in the fresh, dried, canned and frozen mushroom samples. The protein content of the with and without processed samples was in the ranged of 1.21% and 18.53%. The ash and fat content of the all samples ranged from 2.79% to 5.94% and from 0.53% to 7.99%, respectively. Additionally, the carbohydrate content was found to be between 0.85 and 58.68%. The energy values of the all samples were estimated to be between 27.56-380.75 kcal 100g-1 and 115.63-1608.20 kJ 100g-1. Potassium (108.6-2367.4 mg 100g-1) and phosphor (37.4-182.7 mg 100g-1) were the most abundant minerals in the analysed samples. The chemical composition of the frozen samples had the closest results to the fresh samples. The results of the present research showed that L. semisanguifluus has a high nutritional quality especially the freezing process is the best protection technique rather than the canning process and was suitable especially for consumption in low caloric diets. Based on overall evaluations, it can be deduced that especially dried mushroom samples can be used in powder form (such as spices and enrichment component in many food formulations) in the production of various food products due to their high nutritional components.
THE EFFECTS OF MELATONIN, FLUOXETINE AND THEIR COMBINATIONS ON STRESS INDUCED BEHAVIORAL AND COGNITIVE IMPAIRMENTS IN MICE
Authors: İNCİ ÇAMÇİ Merve , ERDİNÇ Meral , KELLE İlker , UYAR Emre , ERDİNÇ Levent
Published: December 2022

Objective: Melatonin (Mel) is a hormone with anti-depressant and anti-oxidant features. It is well known that melatonin protects brain cells from reactive oxygen species and that the brain's high oxygen consumption and lipid content make it particularly vulnerable to oxidative stress caused by prolonged stress. This study aims to investigate the effects of melatonin, fluoxetine and their combinations on emotional memory, depression, and anxiety-like behavioral changes induced by immobilization (Imb) stress. Material and Method: 48 male Balb/c mice were divided into eight groups: Cnt (control), Imb, Imb+Mlt, Imb+Flx (fluoxetine), Imb+Mlt+Flx, Mlt, Flx and Mlt+Flx. For seven days in a row, the mice underwent daily immobilization stress for 6 hours. Mice were treated with Mlt (10 mg/kg) and Flx (20 mg/kg). All animals were subjected to the behavioral tests; forced swimming test (FST), open field test (OFT), elevated plus maze (EPM), passive avoidance test (PAT) and hot plate (HP) test. After all behavioral tests, brain tissues were obtained for malondialdehyde level analysis. Result and Discussion: OFT test data showed the time spent in the central zone and the number of entrances to the central area were significantly lower in the Imb group compared to the Cnt group, these were higher in the Imb+Flx, Imb+Mlt, Imb+Mlt+Flx groups compared to the Imb group. Also, according to the data obtained from FST, immobile time was significantly higher in the Imb group compared to the Cnt group, it was lower in the Imb+Flx, Imb+Mlt, Imb+Mlt+Flx groups compared to the Imb group. Besides, it was demonstrated that the emotional memory index was statistically higher in the Imb group compared to the Cnt group, and the increasing of memory index returned to normal in the Imb+Mlt and Imb+Mlt+Flx groups with PAT. And also, lipid peroxidation level, which increased in the Imb group, decreased significantly in the Imb+Flx, Imb+Mlt, and Imb+Mlt+Flx groups. As a result, it was observed that melatonin has anti-depressant, anxiolytic, antioxidant effects and normalized emotional memory. Also, melatonin, fluoxetine and their combinations exert similar effects in the present study.
The Effect of Cooperative Learning Model Type of Team Assisted Indivisualization Assisted LKPD on Mathematics Learning Outcomes
Authors: Sari Mentari Aulia , Baharullah Baharullah , Rukli Rukli
Published: December 2022

The purpose of the study was to determine the students' mathematics learning outcomes by using a cooperative learning model of team assisted individualization type assisted by hots-based worksheets; and the effect of cooperative learning model type team assisted individualization assisted LKPD based hots on students' mathematics learning outcomes. The method used is an experiment with sampling determined by taking the available classes without doing random sampling. The experimental class and control class were determined by lottery, the results of the draw determined that class V SD Mallengkeri I was the control class and class V was SD Mallengkeri II as the experimental class, namely the class that was given treatment. The data analysis technique in this study used descriptive statistical analysis. As a requirement, test requirements were carried out, namely normality test and homogeneity test using Kolmogorov-Smirnov and Levene's test. After that, the hypothesis is tested using the Paired sample test. The results showed that the mean of the experimental class was 81, 88 while the mean of the control class was 68, 88. Based on data analysis with the Paired sample test. which was carried out at the 95% confidence level, the results were 0.000 <0.05, which means H0 is rejected. To find out the difference in student learning outcomes and understanding between the experimental class and the control class, the N-gain test was carried out using the N-Gain formula. Based on the calculation results obtained, for the experimental class of 0.58 which shows an increase in understanding in the medium category. Based on these data, it can be concluded that the use of the Team Assisted Individualization learning model has an effect on the learning outcomes of fifth graders at SD Cluster III Tamalate Makassar
Implementation of Excellent Learning at Elderly Pesantren of Nurul Iman in Karanganyar Regency
Authors: Naj'ma Dinar Bela Ayu , Bakri Syamsul
Published: December 2022

This study purposes to (1) determine the implementation of al-Qur'an learning for the Elderly Pesantren Nurul Iman of Karanganyar, (2) describe the implementation of worship fiqih learning for the elderly, and (3) explain the process of character education for the Elderly Pesantren Nurul Iman of Karanganyar. This research was conducted in August 2020 – January 2021. The subjects in this study were all asatidz (teachers) and elderly students of Pesantren Nurul Iman in Karanganyar Regency. Meanwhile, the selected research informants were caregivers, asatidz, students, local government and pesantren education experts. This research applied qualitative methods and case studies.

The results reveal that: (1) The implementation of learning the Qur’an for the elderly at Pesantren Nurul Iman Karanganyar is carried out using the Iqro method and the tsaqifa method. Class grouping is based on the individual abilities of elderly students and does not use the average model as the class system in general. This shows that learning the Qur'an for the elderly needs to have attention in the abilities of each elderly student, so that the superior learning method is very relevant to use. (2) The implementation of worship fiqh learning for the elderly at Pesantren Nurul Iman Karanganyar is carried out with the bandongan model. To evaluate the success of learning fiqh of worship, a practicum method is used, namely the practice of fiqh of worship, especially the practice of pasolatan fiqh. With this mentoring model, the process of learning fiqh worship becomes effective, not only in fiqh knowledge but also in worship practices. (3) The process of character education for the elderly at the Elderly Pesantren of Nurul Iman Karanganyar is carried out through integrating character education in rituals and dzikr, sports and arts, in addition to character building through lectures delivered in each study activity. This shows that character education can be effective if it is carried out with affective activities not just cognitive.
Implementation of Social Science Learning on Character Building of Students in Elementary Schools
Authors: Lestari Nur’im Septi
Published: December 2022

The school curriculum assists students in developing the knowledge, skills, attitudes, values, and morals needed to participate in community life at the local, national and global levels. This study aims to determine the implementation of Social Science learning in forming students' character in elementary schools. This research is a literature review research using the Google Scholar search engine with a total of 68 articles. The results obtained 11 articles that were by the inclusion and exclusion criteria. The results showed that the process of implementing or implementing Social Science learning was carried out properly by the goals of national education and then carried out character education or formed the character of elementary school students by the cultural character of the local community. However, there are several obstacles such as the problem of assessing attitudes and environmental factors, so the solution to overcome the problem is to make an assessment format and install monitoring cameras in every hallway and classroom.
The Influence of the Role of the School Committee on the Implementation of School-Based Management
Authors: Jumirin Jumirin , Murniati Ngurah Ayu Nyoman , Wuryandini Endang
Published: December 2022

This study aims to determine the influence of the role   of school committees on the implementation of school-based management (SBM) in private  elementary schools in Pemalang district. The method used in this study is a descriptive method with a quantitative approach, namely research with quantitative data which is then processed and analyzed for conclusions. The first step before the research is taken is to conduct a theoretical study, then the following stages are carried out; first, compiling research instruments, secondly testing the validity and reliability of instruments, thirdly the process of data retrieval, fourth tabulation of data, data processing and interpretation of data, fifth drawing conclusions. The results showed that; first, The role  of the  school committee  as a  judge, supporter, mediator  and controller of the implementation of  SBM obtained a minimum  score of 69 and a maximum score of   202 with a score range of  133.    The data  can be described as saying that  out of 100 respondents who  stated that the role of  the  school committee was good, 13 people  were equivalent to 13%,  stated that 37  people played  a good role.   37%, stated that   39  people played a role equivalent to 3 9% stated  that they played less role as many as 9 people equivalent to   9% and respondents who stated that they did not play a role as   many as 2 people were equivalent to  2%. With a mean value of  149.27 and a mode  value of 162, the value is included in the interval class 150 – 176 in the  good/high category.  The conclusion  of  this study is that the level of  SBM implementation in Pemalang District Private Primary School is influenced by the level of role of  the school committee.   The higher the  role of the school  committee, the more the implementation of SBM will increase. Similarly, if the role of the school  committee is low or lacks a role, then the level of implementation of SBM will also decrease.
Sensory Evaluation of Toma–Pep Ketch–up Prepared from Two Local Varieties of Fresh Tomato (Lycopersicum esculentum Mill)
Authors:   Department of Food Technology, Federal Polytechnic, PMB 1012, Kaura–Namoda, Zamfara state, Nigeria. Institution E–mail: sirajfuntua.fst@fedponam.edu.ng (MSF)., Sirajo Funtua Mohammed , Osman Cavus ,   Department of Gastronomy and Culinary Arts, Faculty of Tourism, Abant Izzet Baysal University, 14840–Mengen, Bolu, Turkey. Institution E–mail: osmancavus@ibu.edu.tr (CO)., Dikko AbdulAziz Mohammed ,   Department of Food Technology, Federal Polytechnic, PMB 1012, Kaura–Namoda, Zamfara state, Nigeria. Institution E–mail: sirajfuntua.fst@fedponam.edu.ng (MSF).
Published: December 2022

This study focused on the development and sensory evaluation of Toma–Pep Ketch–Up (TPK) prepared from two local species of fresh Tomato fruits (Ronita and UTC); all the samples,
An Unusual Cause of Anisocoria
Authors:   Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro (UFRJ), Serviço de Neurologia. Rio de Janeiro, RJ, Brasil. (https://orcid.org/0000-00017147-6418), Evangelista Rodrigues Pereira Victor , Ecard Dacache Thais ,   Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro (UFRJ), Serviço de Neurologia. Rio de Janeiro, RJ, Brasil. (https://orcid.org/0000-00030799-0388), Abreu Mermelstein Sofia ,   Hospital Universitário Pedro Ernesto, Universidade Estadual do Rio de Janeiro (UERJ), Serviço de Neurologia. Rio de Janeiro, RJ, Brasil. (https://orcid.org/0000-0002-52924518). Email: sofiamermelstein@gmail.com.
Published: December 2022

A 21-year-old woman presented to the emergency department complaining of blurred vision and anisocoria that had started a few minutes after putting on her contact lenses.
Paleolitik Çağ’da Atalar Kültü Düşüncesi Üzerine Bir Değerlendirme
Authors: ÖZDEMİR Muammer
Published: December 2022

İnsanın anlam arayışında, varoluşsal sorgulamalarında ve kavramsal anlamlandırmalarında en önemli unsurlardan biri dindir. Din ve dine dair tüm unsurlar, geçmişten günümüze bütün toplumların hayatlarında başat faktörlerden olmuştur. Bu düzlemde geçmişinden kopmak istemeyen, ölen yakınlarıyla iç içe bir hayat tercih eden ve onların öteki dünyasını bu dünyadan şekillendirmek isteyen aynı zamanda bu dünyanın da öteki dünya tarafından şekillenmesini hedefleyen kadim insanın, idraki derinliği ve dindarlık kipleri kuşkusuz bugünle özdeşleştirilebilir niteliktedir. Bu örüntü içerisinde çalışmada, Aydınlanma Çağı’nın ve batının kendini üstün görme fikrinin bir süreği olan dine köken arama girişimleri kapsamında atalar kütü fikrine değinilmiş, Atalar ile olan münasebetin Paleolitik Çağ’daki yansıması irdelenmiştir. Mağara resimleri üzerinden sembolik anlatımlar ile ölüm ve ruh arasındaki bağ kurulmaya çalışılmış, ölüme dair Paleolitik insanının bakışı sorgulanmıştır. Dinsel ve insani zaruretlerin ölü gömme uygulamalarına yansıması ile ataların hem bu dünyadaki konumlarına hem de öteki dünya algısına ve oradaki konumlarına dair arkeolojik ve teolojik veriler sunulmuştur. Tüm bunları yaparken günümüz yerel topluluklardaki arketipsel olarak yansımalar da ayrıca incelenerek Paleolitik insanının hem düşüncesi hem de dinseli hakkında yargıya varılmaya çalışılmıştır. Disiplinlerarası çalışmaların bu sahadaki tutumları, çalışmanın belirleyici unsurudur. Tarihsel anlamda hem Paleolitik Çağ insanının dine dair tutumu hem de bu tutumun kapsamında atalar ile olan münasebeti oldukça önemlidir.
İlköğretim Matematik Öğretmeni Adaylarının Matematiksel Modelleme Süreçleri: Su İsrafı Örneği
Authors: KAYA Deniz , KEŞAN Cenk
Published: December 2022

Bu araştırmanın amacı, ilköğretim matematik öğretmeni adaylarının matematiksel modelleme süreçlerini incelemektir. Araştırmada, nitel araştırma yöntemi desenlerinden durum çalışması kullanılmıştır. Araştırmaya, 49’u kadın ve 14’ü erkek olmak üzere toplam 63 ilköğretim matematik öğretmeni adayı katılmıştır. Katılımcılar, amaçlı örnekleme yöntemleri içerisinden ölçüt örnekleme yöntemine göre belirlenmiştir. Araştırmanın veri toplama araçları, araştırmacılar tarafından gerçek yaşam durumuna uygun olarak hazırlanmış matematiksel modelleme problemine ilişkin yazılı yanıt kağıtlarından ve gözlem notlarından oluşmaktadır. Verilerin analizinde içerik analizinden yararlanılmıştır. Araştırmadan elde edilen bulgular, öğretmen adaylarının modelleme basamaklarındaki yeterlilikleri yerine getirmede birtakım güçlükler yaşadığını göstermektedir. Öğretmen adaylarının gerçek hayat problemini anlama, matematiksel model oluşturma ve problemi çözmek için matematiksel işlem yapma basamaklarında sorunlar yaşamadıkları ancak gerçek bir durumda matematiksel sonuçları yorumlamada ve sonuçların geçerliliğini doğrulamada sorunlar yaşadıkları belirlenmiştir. Çalışma sonunda, öğretmen adaylarının model kurma ile ilgili farkındalıklarının artırılması öneri olarak sunulmuştur.
Vocal Imitation and Linguistic Processing of Super Mario Theme Music by Yorùbá Gamers
Authors: Akinbo Samuel
Published: December 2022

Gaming culture among Yoruba millennials involves vocal imitating the music of the video gam, Super Mario Bros. The themes of the linguistic interpretations are comparable to those of music texts at traditional Yoruba competitions. Drawing on the Yoruba music tradition, the account in this work is that, to the gamers, the background music of the video game performs a similar function as the music at traditional Yoruba competitions. The choice of words in the linguistic interpretation is conditioned by the situational contexts or scenes where the music is heard in the video game. The results of an acoustic analysis show that the choice of words in the linguistic interpretations is also determined by mapping the pitch trajectories of the music melodies to the tones of the gamers' native language. This study suggests that the linguistic processing of music may not only involve phonetic iconicity but contextual inference and social expectation.
Non-steroidal anti-inflammatory drug-induced anaphylaxis infrequent in 388 patients with mastocytosis: A two-center retrospective cohort study
Authors: Bonadonna Patrizia , Olivieri Francesco , Jarkvist Jesper , Nalin Francesca , Zanotti Roberta , Maclachlan Laura , Gülen Theo
Published: December 2022

Background

Anaphylaxis is a well-known feature of mastocytosis, particularly in relation to hymenoptera venom stings. It is therefore hypothesized that mastocytosis patients may also be predisposed to severe hypersensitivity reactions to certain medications including non-steroidal anti-inflammatory drugs (NSAIDs). For this reason, these patients are usually discouraged from using these drugs. The current study aimed to determine the prevalence and evaluate the severity of NSAID-related hypersensitivity reactions among patients with mastocytosis.

Methods

A retrospective study was conducted among a total of 388 (≥18 years old) consecutive patients from two independent European mastocytosis centers, in Sweden and Italy. Patients underwent a thorough allergy work-up where self-reported NSAID-hypersensitivity reactions were re-evaluated by an allergist in the first cohort (202 patients) and results were validated in the second cohort (186 patients).

Results

Overall frequency of NSAID-hypersensitivity was 11.3% in the total study cohort. Most patients reacted with cutaneous symptoms (89%), whereas severe hypersensitivity reactions were infrequent with only 11 patients (2.8%) experiencing anaphylaxis. All NSAID-related hypersensitivity reactions had occurred before mastocytosis was diagnosed. There was no difference between the groups regarding gender, baseline tryptase levels or presence of atopy, asthma/rhinitis.

Conclusion

Our study indicates an approximate 4-fold increased prevalence of NSAID hypersensitivity among mastocytosis patients compared to the general population. However, most NSAID reactions were limited to the skin as the prevalence of overall anaphylaxis was infrequent. Our results support that mastocytosis patients with a known tolerance to NSAIDs can continue using these medications without special precautions, whereas those with a prior reaction to NSAIDs should undergo thorough allergy work-up, including drug challenges.
The hybrid model of autoregressive integrated moving average and fuzzy time series Markov chain on long-memory data
Authors: Devianto Dodi , Ramadani Kiki , Maiyastri  , Asdi Yudiantri , Yollanda Mutia
Published: December 2022

Introduction

The price of crude oil as an essential commodity in the world economy shows a pattern and identifies the component factors that influence it in the short and long term. The long pattern of the price movement of crude oil is identified by a fractionally time series model where the accuracy can still be improved by making a hybrid residual model using a fuzzy time series approach.

Methods

Time series data containing long-memory elements can be modified into a stationary model through the autoregressive fractional integrated moving average (ARFIMA). This fractional model can provide better accuracy on long-memory data than the classic autoregressive integrated moving average (ARIMA) model. The long-memory data are indicated by a high level of fluctuation and the autocorrelation value between lags that decreases slowly. However, a more accurate model is proposed as a hybridization time series model with fuzzy time series Markov chain (FTSMC).

Results

The time series data collected from the monthly period of West Texas Intermediate (WTI) oil price as the standard for world oil prices for the 2003–2021 time period. The data of WTI oil price has a long-memory data pattern to be modeled fractionally, and subsequently their hybrids. The times series model of crude oil price is obtained as the new target model of hybrid ARIMA and ARFIMA with FTSMC, denoted as ARIMA-FTSMC and ARFIMA-FTSMC, respectively.

Discussion

The accuracy model measured by MAE, RMSE, and MAPE shows that the hybrid model of ARIMA-FTSMC has better performance than ARIMA and ARFIMA, but the hybrid model of ARFIMA-FTSMC provides the best accuracy compared to all models. The superiority of the hybrid time series model of ARFIMA-FTSMC on long-memory data provides an opportunity for the hybrid model as the best and more precise forecasting method.
A review on poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(3HB-co-3HHx)] and genetic modifications that affect its production
Authors: Tang Hui Jia , Neoh Soon Zher , Sudesh Kumar
Published: December 2022

Polyhydroxyalkanoates (PHAs) have garnered global attention to replace petroleum-based plastics in certain applications due to their biodegradability and sustainability. Among the different types of PHAs, poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(3HB-co-3HHx)] copolymer has similar properties to commodity plastics, making them a suitable candidate to replace certain types of single-use plastics, medical devices, and packaging materials. The degradation rate of P(3HB-co-3HHx) is faster than the commercial petroleum-based plastics which take a very long time to be degraded, causing harmful pollution to both land and marine ecosystem. The biodegradability of the P(3HB-co-3HHx) is also dependent on its 3HHx molar composition which in turn influences the crystallinity of the material. Various metabolic pathways like the common PHA biosynthesis pathway, which involves phaA, phaB, and phaC, β-oxidation, and fatty acids de novo synthesis are used by bacteria to produce PHA from different carbon sources like fatty acids and sugars, respectively. There are various factors affecting the 3HHx molar composition of P(3HB-co-3HHx), like PhaCs, the engineering of PhaCs, and the metabolic engineering of strains. It is crucial to control the 3HHx molar composition in the P(3HB-co-3HHx) as it will affect its properties and applications in different fields.
A multi-attribute utility decision support tool for a smart campus—UAE as a case study
Authors: Ahmed Vian , Saboor Sara , Ahmad Norita , Ghaly Megan
Published: December 2022

The advancement in technologies in the education sector has improved living standards and acts as a sustaining factor for future development. Recently, the integration of technologies into the campus to transform it into a Smart Campus has experienced exponential growth in interest from researchers. Though various definitions of the concept of ‘Smart Campus’ have been proposed, the integration of the end users’ perception is always lacking in the concept. This study, therefore, intends to build on the theory to classify the most significant criteria that underpin the ‘Smart Campus’ by considering the institute’s stakeholders’ perceptions. A multi-step methodological approach is adopted to develop a decision support tool that allows the decision makers to invest in the optimum solution to transform a traditional campus into a smart campus. The study initially looks into the criteria and sub-criteria from the literature that defines a ‘Smart Campus’. Secondly, a survey was conducted by targeting a sample of students, faculty, administrative staff, and IT support personnel from a leading institute in the UAE region as a single case study. Thirdly, an AHP analysis was performed among different stakeholders. The findings suggested that there exists a consensus among the perception of a diverse group of participants who perceive smart security and safety, campus navigation, and adaptive learning as the most important criteria and applications to transform the traditional campus into a smart campus. Finally, the decision support tool development on the Utility function model allows the decision makers, i.e., Network Managers, IT Managers, Systems and Cloud Managers, and Senior Managers from the Finance departments, to make informed and strategic decisions in terms of the optimum solution for the transformation from a traditional campus to a smart campus.
A review of current evidence about lncRNA MEG3: A tumor suppressor in multiple cancers
Authors: Xu Jie , Wang Xia , Zhu Chunming , Wang Kefeng
Published: December 2022

Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) is a lncRNA located at the DLK1-MEG3 site of human chromosome 14q32.3. The expression of MEG3 in various tumors is substantially lower than that in normal adjacent tissues, and deletion of MEG3 expression is involved in the occurrence of many tumors. The high expression of MEG3 could inhibit the occurrence and development of tumors through several mechanisms, which has become a research hotspot in recent years. As a member of tumor suppressor lncRNAs, MEG3 is expected to be a new target for tumor diagnosis and treatment. This review discusses the molecular mechanisms of MEG3 in different tumors and future challenges for the diagnosis and treatment of cancers through MEG3.
Binding mechanism and SERS spectra of 5-fluorouracil on gold clusters
Authors: Si Nguyen Thanh , Nhat Pham Vu , Nguyen Minh Tho
Published: December 2022

The adsorption behaviour of the 5-fluorouracil (5FU) on small gold clusters AuN with N = 6, 8, 20 was evaluated by means of density functional theory using the PBE-D3 functional in combination with a mixed basis set, i.e. cc-pVDZ-PP for gold atoms and cc-pVTZ for non-metal elements. The binding energies between 5FU and gold clusters were determined in the range of 16–24 and 11–19 kcal/mol in gas-phase and aqueous media, respectively. The corresponding Gibbs energies were found to be around -7 to -10 kcal/mol in vacum and sigificantly reduced to -1 to -6 kcal/mol in water solution, indicating that both the association and dissociation processes are likely spontaneous. An analysis on the charge density difference tends to confirm the existence of a charge transfer from the 5FU molecule to Au atoms. Analysis of the surface-enhanced Raman scattering (SERS) spectra of 5FU adsorbed on the Au surfaces shows that the stretching vibrations of N−H and C=O bonds play a major role in the SERS phenomenon. A mechanism for the drug releasing from the gold surfaces is also proposed. The process is triggered by either the low pH in cancerous tumors or the presence of cysteine residues in protein matrices.
Teaching as evolutionary precursor to language
Authors: Gärdenfors Peter
Published: December 2022

The central thesis of this article is that the evolution of teaching is one of the main factors that lead to increasingly complex communicative systems in the hominin species. Following earlier analyses of the evolution of teaching, the following steps are identified: (i) evaluative feedback, (ii) drawing attention, (iii) demonstration and pantomime, (iv) communicating concepts, (v) explaining relations between concepts, and (vi) narrating. For each of these step the communicative and cognitive demands will be analyzed. The focus will be on demonstration and pantomime, since these seem to be the evolutionarily earliest unique human capacities. An important step is the transition from pantomime for teaching to pantomime for informing and how this in turn leads to communicating concepts. As regards explaining relations between concepts, the focus will be of the role of generics in teaching and communication. Analyzing these topics involves combining cognitive science with evolutionary theory, archaeology and theories of communication. Two factors are important as a background: (i) the evolution of prospective planning, that is, planning for future goals, and (ii) the evolution of a theory mind. These capacities are central in explaining how more advanced forms of teaching, communication and cooperation emerged along the hominin line.
Anti-hyperglycemic contours of Madhugrit are robustly translated in the Caenorhabditis elegans model of lipid accumulation by regulating oxidative stress and inflammatory response
Authors: Balkrishna Acharya , Gohel Vivek , Pathak Nishit , Tomer Meenu , Rawat Malini , Dev Rishabh , Varshney Anurag
Published: December 2022

Background

The prevalence of diabetes has considerably increased in recent years. In the long run, use of dual therapy of anti-diabetic agents becomes mandatory to attain euglycemia. Also, the incidences of diabetes-related co-morbidities have warranted the search for new therapeutic approaches for the management of the disease. Traditional herbo-mineral, anti-diabetic agents like Madhugrit are often prescribed to mitigate diabetes and related complications. The present study aimed to thoroughly characterize the pharmacological applications of Madhugrit.

Methods

Phytometabolite characterization of Madhugrit was performed by ultra-high performance liquid chromatography. Evaluation of cell viability, α-amylase inhibition, glucose uptake, inflammation, and wound healing was performed by in vitro model systems using AR42J, L6, THP1, HaCaT cells, and reporter cell lines namely NF-κB, TNF-α, and IL-1β. The formation of advanced glycation end products was determined by cell-free assay. In addition, the therapeutic potential of Madhugrit was also analyzed in the in vivo Caenorhabditis elegans model system. Parameters like brood size, % curling, glucose and triglyceride accumulation, lipid deposition, ROS generation, and lipid peroxidation were determined under hyperglycemic conditions induced by the addition of supraphysiological glucose levels.

Results

Madhugrit treatment significantly reduced the α-amylase release, enhanced glucose uptake, decreased AGEs formation, reduced differentiation of monocyte to macrophage, lowered the pro-inflammatory cytokine release, and enhanced wound healing in the in vitro hyperglycemic (glucose; 25 mM) conditions. In C. elegans stimulated with 100 mM glucose, Madhugrit (30 µg/ml) treatment normalized brood size, reduced curling behavior, decreased accumulation of glucose, triglycerides, and lowered oxidative stress.

Conclusions

Madhugrit showed multimodal approaches in combating hyperglycemia and related complications due to the presence of anti-diabetic, anti-inflammatory, anti-oxidant, wound healing, and lipid-lowering phytoconstituents in its arsenal. The study warrants the translational use of Madhugrit as an effective medicine for diabetes and associated co-morbidities.