bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of Farmer’s Training in Nepal: A Review
Authors: Baral R. Sudikshya , Gyawali Kiran
Published: November 2024

Farmer's training is a method of agricultural extension service delivery. This paper through a thorough review of literature aims to access the effectiveness of farmer training programs in Nepal for transfer of knowledge, creation of awareness, adoption of improved practices and technologies, and improvement in farmer efficiency and farm productivity.
ECOSYSTEM COLLABORATION FOR CLIMATE ACTION: A CASE STUDY OF THE ILCA PROJECT
Authors: Agheniței Ancuța , Nastase Carmen , Chașovschi Carmen
Published: November 2024

In recent years, the number of initiatives dealing with climate change has increased significantly as human activity releases more and more greenhouse gases into the environment. There is no doubt that the effects of these emissions are numerous and increasingly alarming. Against this background, this paper assumes that climate change requires the engagement of various groups of stakeholders. This engagement is referred to in this paper as ecosystem cooperation for climate action. A feature of ecosystem cooperation is the potential to create a multistakeholder network of new partnerships that can generate innovative solutions to climate change problems. This paper argues that ecosystem collaboration is particularly important for both preventing and responding to climate change. Following a theoretical explanation of the concept of ecosystem collaboration, a case study on climate change and sustainability is presented. This case study highlights best practise examples within a European project entitled “Innovation Laboratories for Climate Actions” (ILCA). Through a consortium of six universities and three research institutes from different European countries, the ILCA project aimed to engage multiple stakeholders in national, regional and local ecosystems to develop innovative solutions to tackle climate change. The project brought together businesses, public administrations, civil society and academia from each country. The findings of this paper emphasise the importance of the ILCA project in tackling climate change through ecosystem collaboration and the establishment of a ‘Climate Innovation Lab’ at the Stefan cel Mare” University in Suceava. Such a lab brings together experts from different fields such as economics, engineering and medicine to find innovative solutions to climate problems. We also emphasise the active role of innovation in helping tourism businesses to adapt to climate change. Innovation and collaboration are crucial to fostering a cooperative environment in relation to climate change mitigation.
Management of the Portfolio of Works For A Public Hospital Complex
Authors: Carneiro Mauro Lucio Pastor , Reis Luiza Santangelo , Petri Sérgio Murilo
Published: November 2024

Objectives: The main objective of this research is to develop a decision-making support model for prioritizing works projects in a public hospital complex, establishing criteria for characterizing and evaluating these projects.
 
Theoretical reference: Strategic management; management control; project portfolio management; multi-criteria analysis; hospital works projects.
 
Method: This is a quantitative exploratory research based on the Multi-Criterion Decision Support Methodology (MCDA), whose primary data are derived from semi-structured questionnaires. This methodology makes it possible to carry out a multi-criterion analysis of a large quantity of information, involving conflicting interests amongst themselves in decision-making contexts of high uncertainty and high complexity.
 
Results and Discussion: A model for evaluating demands was developed, consisting of 16 criteria for analysis (descriptors), grouped into four thematic groups, whose measurement scales, once transformed into cardinal quantities, present the performance of each characteristic under study and make possible the construction of a global model for evaluating demands. These criteria are based on the decision-makers' perceptions of the institutional needs of works projects, revealing their concerns about the infrastructure problems in the body's buildings.
 
Implications of Research: The implementation of this model leads to the creation of a service queue for the demands of works projects that materializes the priority actions in the area of infrastructure from the objectives, expectations and preferences of the decision makers. In the end, the model developed makes it possible, starting from the attribution and weighting of values, to define institutional priorities.
 
Originality/Value: The research points to a path for overcoming major challenges in the decision-making on the prioritization of works projects in a public hospital, highlighting the high volume of demands, conflicts of interest, resource constraint and obsolescence of buildings and equipment.
Applications And Uses of Coffee Silver Skin (CSS): A Systematic Analysis
Authors: Galvão Hilton , Righi Eléia , Neumann Deise , Putti Gilberto , Silva Dieizon Rodrigues da , Machado Fernando
Published: November 2024

Objective: Considerando el tema relativamente nuevo con potencial de exploración, el objetivo fue realizar una revisión sistemática de la literatura sobre el café con piel plateada o Coffee Silver Skin (CSS), así como sus principales aplicaciones y usos en (nuevos) productos, por- productos, aditivos tecnológicos e ingredientes funcionales.
 
Theoretical Framework: During various stages of coffee processing, as well as other crops, by-products are produced in large quantities, generating pollution to the environment, due to their disposal without the appropriate added value that can be achieved with them, if they are studied and approved. for consumption. Among other residues, there is the silver coffee film or Coffee Silver Skin (CSS), obtained in the roasting stage of the beans, highly available in Brazil.
 
Method: The bibliographic method of organization and search was used for the proposed study, bringing a collection of publications on the topic “Coffee Silver Skin”, with quotation marks, from the historical series of the CAFe network on the Periódicos CAPES portal from 2016 to 2024 (until 26/ 09/2024).
 
Results and Discussion: In this research, 29 articles on the topic were used. Only from 2016 onwards did articles begin to be published and have a high degree of impact, and in the year 2023 there was the largest number of publications on this subject with greater relevance and greater impact on the scientific production of the database. data. These numbers demonstrate that this scientific field is still in the process of developing research and techniques.
 
Research Implications: According to the data obtained, we can see that several uses have been indicated for coffee silver film (CSS), such as: phenolic compounds, functional biscuits, sound absorption and other applications in this type of industry, dietary products, fertilizers and covering film for agriculture.
 
Originality/Value: Coffee and coffee waste combined with their high concentration of fiber, coloring pigments, antioxidant compounds and proteins have immense potential as new products and need to be better explored.
Sustainable Environmental Educational Policies: Study in an Extractivist Reserve School in a Municipality on the Coast of Ceará-Brazil
Authors: Oliveira Lucineide de Abreu , Xavier Antônio Roberto , Amorim Aiala Vieira , Kanikadan Andrea Yumi Sugishita , Santos José Cleilson de Paiva dos , Muniz Karla Renata de Aguiar , Vasconcelos José Gerardo
Published: November 2024

Objective: Identifying sustainable environmental educational practices, in the political propos- pedagogical of Municipal Fundamental Teaching – EMEF Good Jesus of the Navigants, and the relationship of that work with the community Reserve Extractive Green Song Marine in Beberibe, Ceará, Brazil, while Unit of Preservation and Conservation.
 
Theoretical Framework: It is based on the concepts of sustainable environmental education based on a curricular proposal contained in the Pedagogical Political Projects (PPP) of basic education, taking as a starting point an Elementary School in the coastal interior of the State of Ceará, Brazil
 
Method: Combines literature review with case study of empirical research with content analysis of Political Pedagogical Projects of a basic education school in the coastal interior of Ceará in Brazil.
 
Results and Discussion: It was found that, in the previous decade (2010-2020), several actions were carried out between school and community, highlighting the importance of preserving the local environment. However, in recent years, there is no project proposal for this purpose in the pedagogical documents, nor is there any in the Management Plan of the Association of Residents of the Extractive Reserve Community of Prainha de Canto Verde, Beberibe, Ceará, Brazil.
 
Implications Research: Research contributes to the development of strategies for environmental education and sustainability in general and to facing challenges in defense of a protected and sustainable territory, based on a local reality
 
Originality/Value: The research proposes a practical approach to identifying pedagogical practices of sustainable environmental education by analyzing some Political Pedagogical Projects (PPPs) of the school institution in the coastal community Reserva Extractiva do Canto Verde da Prainha in Beberibe-Ceará Brazil, investigating to what extent such pedagogical proposals favor or have favored the applicability of environmental education, as an incentive for the conservation and preservation of the local environment
Occurrence of Intestinal Parasites with Zoonotic Potential in Fecal Samples from Companion Animals in Public Squares of Mineiros-GO
Authors: Silva Jhosani Beatriz Bispo da , Ribeiro Rodrigo Martins , Ribeiro Debora da Silva Freitas
Published: November 2024

Objective: To evaluate the occurrence of intestinal parasites with zoonotic potential in fecal samples collected from the main public squares of Mineiros-GO.
 
Theoretical Framework: Companion animals are increasingly present in family life. This closer relationship between humans and animals raises public health concerns, considering that companion animals are primary disseminators of parasites with zoonotic potential. Public squares experience high foot traffic from both people and animals, including both domesticated and stray animals, which deposit feces in these areas, thus facilitating the spread of parasites.
 
Method: A total of 250 fecal samples were collected, stored in sterile collection tubes, properly identified, and securely sealed, and then transported to the laboratory under refrigeration. The techniques used for sample analysis were the Faust and Willis-Mollay methods.
 
Results and Discussion: Of the samples, 74% tested positive for Ancylostoma spp., 26% for Toxocara spp., 5.5% for Trichuris vulpis, 7.5% for Giardia spp., and 4% for Isospora spp. The results are concerning for public health due to the zoonotic potential of the parasites found.
 
Research Implications: The high prevalence of intestinal parasitoses in public areas highlights the need for rigorous sanitary measures to prevent the spread of zoonoses.
 
Originality/Value: The relevance of this research lies in its potential to inform and guide public policies and raise public awareness about the importance of hygiene practices and responsible pet care to prevent parasitic infections.
Teacher Training in Sexual Education For Primary School Teachers
Authors: Cabrera-Fajardo Deyci-Patricia , Acosta Ferney Mora , Chirinos Sunny Perozo
Published: November 2024

Objective: To describe the sexual education training of primary school teachers in the Educational Institutions of the municipalities of Albán and San Bernardo, Nariño, Colombia.
 
Theoretical Framework: To understand the context of the research, various definitions regarding the importance of teacher training in sexuality topics are presented to strengthen comprehensive education.
 
Method: The research was developed under the holistic understanding of science, considered descriptive in nature, with a field design and contemporary cross-sectional approach. The population consisted of 86 teachers. Data collection was carried out using a survey technique with a knowledge guide instrument, whose validity index was calculated through expert judgment, yielding a value of 0.74. The reliability of the instrument obtained a Cronbach's Alpha coefficient of 0.93. Data analysis was performed using descriptive statistics, specifically the median as a measure of central tendency, as well as absolute and percentage frequency; the data were processed using SPSS21 software.
 
Results and Discussion: The findings revealed that teachers in the institutions have a very low level of training in sexual education, which translates into a lack of knowledge and skills to address sexuality in the classroom.
 
Implications of the Research: It is urgent to implement training programs that prepare teachers to face these challenges.
 
Originality/Value: This research paves the way for formulating educational policies and training processes in sexual education to strengthen sexual education.
Yapraktan Yapılan Gibberellik Asit Uygulamalarının Patates (Solanum tuberosum L.)’de Yumru Verimi, Kalitesi ve Dormansi Süresine Etkileri
Authors: Ok Fatma Zehra , Şanlı Arif
Published: November 2024

Bu çalışma, farklı dozlarda Gibberellik asit (GA3) uygulamalarının patateste yumru verimi, kalitesi ve dormansi süresi üzerine etkilerinin belirlenmesi amacıyla yürütülmüştür. GA3 uygulamalarına (0, 50, 100 ve 200 mg/L GA3) dikimden 45 gün sonra (çiçeklenme öncesi dönem) başlanarak 15 gün aralıklar ile 4 farklı dönemde yapraklara püskürtme şeklinde yapılmıştır. Çalışmada GA3 uygulamaları ile birlikte ocak başına yumru sayısında % 56, yumru veriminde ise % 36’ya varan artış meydana gelmiş, ortalama yumru ağırlığı ve pazarlanabilir yumru oranları ise önemli derecede azalma göstermiştir. En yüksek yumru verimi dikimden 75 gün sora yapılan 100 ve 200 mg/L GA3 dozlarından elde edilmiştir. GA3 uygulamaları yumrularda şekil bozulmalarına yol açmış, genel olarak doz artışı ile birlikte çatlak yumru oranı ve sekonder gelişme gösteren yumru oranı artmıştır. GA3 uygulamaları yaprak klorofil içeriği (SPAD değeri) ile yumru kuru madde oranının azalmasına neden olmuştur. Kontrolde ortalama 110 gün olan dormansi süresi dikimden 90 gün sonra yapılan 200 mg/L GA3 uygulamaları ile 80 güne kadar kısalmıştır. Çalışmada, tohumluk amacıyla yapılacak üretimlerde yapraktan yapılan GA3 uygulamaları ile patateste yumru sayısı ve veriminin önemli derecede arttırılabileceği ve yumruların hasat sonrası depolama devresinde dormansi sürelerinin kısaltılarak özellikle ikinci üretimler için avantaj sağlanabileceği anlaşılmıştır.
Çimento Yerine Sığır Gübresi Külünün Kısmi İkamesi ile Üretilen Hafif Betonun Bazı Özelliklerinin Belirlenmesi
Authors: Korkmaz Ahmet , Şahin Sırrı
Published: November 2024

Bu çalışmada; Türkiye'de kırsal alanlarda ısınma amaçlı olarak kullanılan yenilenebilir enerji kaynaklarından güneşte kurutulmuş sığır gübresi külünün (SGK) farklı oranlarda çimento yerine kullanılmasının, hafif betonun basınç dayanımı üzerine etkisinin araştırılması amaçlanmıştır. Araştırmada, hafif agrega olarak pomza bağlayıcı olarak da CEM I 42,5 R tipi çimento ve SGK ikamesi kullanılmıştır. Karışımlara çimento yerine ağırlıkça belirli oranlarda (%0, %5, %10, %15 ve %20) SGK ikame edilerek 5 grup halinde toplam 45 adet 150×150×150 mm’lik küp numune üretilmiştir. Taze beton deneyleri olarak-birim ağırlık deneyleri; serleşmiş beton deneyleri olarak da kuru birim ağırlık, su emme ve basınç dayanımı deneyleri yapılmıştır. SGK kullanılan numunelerde, SGK ikamesinin artması ile kontrol örneklerine göre su emme miktarında bir miktar artış, basınç dayanımlarında ise bir miktar düşüş görülmüştür. %5, %10, %15 ve %20 oranlarında SGK ikamesi ile üretilen numunelerin 28 günlük basınç dayanımı düşüş değerleri kontrol örnekleri ile karşılaştırıldığında sırasıyla %4, %4,6, %5,5 ve %6 olarak belirlenmiştir. Çimento yerine %20 SGK ikamesinin uygulanması, numunelerin 28 günlük basınç dayanımlarında %6’lık bir azalma gözlemlenmiştir.
Substantiation of the composition of sublingual tablets for the treatment of CNS disorders
Authors: Davydova I. O. , Ruban O. A. , Slipchenko H. D. , Zupanets I. V , Ivaniuk O. I.
Published: November 2024

Aim. To develop the composition of sublingual tablets with L-tryptophan, glycine and a dry peony extract.
Materials and methods. L-tryptophan, glycine and a dry peony extract were used as active pharmaceutical ingredients; Lactose GranuLac 200, MCC 102, HPMC methocel K4M CR Premium, HPMC methocel E4M CR Premium, aspartame, maltodextrin, sorbitol, sucralose, Mint cloroph FLV PDR, Strawberry FLV PDR, Apple FLV PDR, Plasdone K-25, crospovidone XL-10, nonessylin and calcium stearate were used as excipients. The pharmacotechnological studies were conducted in accordance with the methods of the State Pharmacopoeia of Ukraine.
Results and discussion. The studies of the pharmacotechnological properties of APIs showed unsatisfactory results (poor fluidity, poor cohesive properties; high hygroscopicity of the peony extract), so it was decided to improve the technological properties of the active substances by wet granulation. Plasdone K-25 (15% aqueous solution) was chosen as a binder. The next step was to select a flour adhesive to improve the bioavailability of the active ingredients. According to the literature, HPMC was included in the composition of the test samples: HPMC methocel E4M CR Premium and HPMC methocel K4M CR Premium. According to the research results, HPMC methocel K4M CR Premium was included in the composition. The tablets developed had a bitter taste due to the presence of tryptophan and the peony extract. To correct the taste and odor, aspartame and Mint cloroph FLV PDR were used. Their optimal content in the formulation was experimentally determined.
Conclusions. As a result of the studies conducted, the following substances have been selected: the binder for granulating the tablet mixture – Plasdone K-25; the flour adhesive to improve bioavailability – HPMC methocel K4M CR Premium; flavors for taste and odor to mask the bitter taste of sublingual tablets – aspartame and Mint cloroph FLV PDR.
The effect of a new phytocomposition based on the cranberry leaf extract and amino acids on the pancreas and liver of rats in the model of diabetes mellitus type 2
Authors: Kononenko N.M. , Anisimova M.S.
Published: November 2024

In pharmacotherapy of diabetes mellitus type 2 and metabolic syndrome, medicinal plants and amino acids are used as an important preventive and therapeutic supplement to correct disorders that develop against the background of insulin resistance, which determines the relevance of developing new domestic combined antidiabetic herbal medicines.
Aim. To study the effect of a phytocomposition based on the polyphenol extract from large-fruited cranberry leaves and amino acids (L-arginine, taurine, glycine) on the state of the liver and pancreas of rats in an experimental model of diabetes mellitus type 2.
Materials and methods. Diabetes mellitus type 2 was reproduced by a single injection of rats with a streptozotocin solution in the dose of 65 mg/kg, intraperitoneally with the previous (15 min) intraperitoneal administration of nicotinamide in the dose of 230 mg/kg against the background of obesity (keeping rats on a high-calorie diet for 12 weeks). The pancreatic and hepatoprotective effect of the phytocomposition was studied according to the morphofunctional state of pancreatic β-cells, the content of glycogen and neutral fats in the liver and morphometric indices in the pancreas.
Results. The phytocomposition studied had a stimulating effect on regenerative processes in the insulin-producing apparatus of the rat pancreas – the severity of proliferation of small β-cells in pancreatic islets significantly increased compared to the control pathology. The phytocomposition at the morphological level showed hepatoprotective properties considerably reducing the manifestations of the toxic-dystrophic action of diabetogens, significantly restoring fat and carbohydrate metabolism in hepatocytes.
Conclusions. The results obtained substantiate the feasibility of further study of the phytocomposition as a promising antidiabetic agent.
The analysis of recombinant insulin production technologies
Authors: Kaliuzhnaia O. S. , Khokhlenkova N. V. , Panenko M. V.
Published: November 2024

Aim. To analyze current trends in insulin production and expression systems used to obtain recombinant proteins.
Materials and methods. The specified goal was achieved using the methods of content analysis, comparative, logical, analytical and generalization of information. The research materials were publications in scientific periodicals, official websites of manufacturing companies.
Results. It has been found that the following expression systems are traditionally used for the commercial production of recombinant human insulins: bacterial – Escherichia coli, and yeast – Saccharomyces cerevisiae. But to meet the global need for insulin, it is necessary to develop new effective expression systems. Therefore, the use of other eukaryotic insulin expression systems that would be suitable for large-scale production is currently being studied. Among such systems, transgenic plants, which are characterized by the absence of potential human pathogens and the presence of post-translational protein modification mechanisms similar to human ones, are promising for introduction into insulin production. Currently, studies using Arabidopsis thaliana, tobacco, lettuce and strawberry plants are successful. Stem cells – embryonic, mesenchymal and induced pluripotent are also considered promising. The methods used in the large-scale production of recombinant insulin based on the synthesis of proinsulin and the two-chain method have been characterized. The technological flowcharts of both technologies have been drawn up, the advantages and disadvantages of each are given.
Conclusions. The analysis of data from the scientific literature has shown that the main methods of producing insulin preparations since the 1980s remain pro-insulin and two-chain methods, which are based on recombinant DNA technologies. The pro-insulin method is considered more efficient and cost-effective compared to the two-chain method since this technology consists of working with a single recombinant strain. The choice between these two methods depends on the specific needs of the manufacturer: for some cases a fast method with proinsulin synthesis is rational, for others – a more accurate and controlled two-chain method. The bacteria – Escherichia coli and yeast – Saccharomyces cerevisiae remain the expression systems used in the existing large-scale production technologies. But using E. coli, insulin precursors are produced in inclusion bodies, and fully functional polypeptides are obtained by solubilization and refolding steps. The yeast-based system yields a soluble insulin precursor that is secreted into the culture fluid, but requires prior humanization due to the risks of an immune response in humans. Thus, current production technologies cannot meet the growing demand for available insulin due to limited production capacity and high production costs, so research is being conducted to find new efficient expression systems, such as plant and mammalian cells, including Arabidopsis thaliana, tobacco, lettuce, strawberry, stem cells.
Assentamento Piraputanga (Diamantino-MT): perspectivas, desafios e a relevância da Previdência Social Rural (PSR)
Authors: Andrade Wellington da Silva , Rambo José Roberto , Silva Flaviana Cavalcanti , Maia Ana Heloisa
Published: November 2024

Este trabalho propõe a caracterização dos perfis socioeconômicos-produtivos das famílias  do Assentamento Piraputanga em Diamantino–MT, bem como, busca verificar o papel da Previdência Social Rural (PSR), no contexto de vida dos sujeitos desse espaço. O estudo baseou-se na experiência de sete famílias, dentre as nove que compunham o assentamento originalmente. No desenvolvimento da pesquisa de campo, privilegiou-se o emprego da entrevista semiestruturada, da observação direta, utilizando-se, ainda, um formulário semiestruturado. Foi possível constatar a escassez de jovens, o que enfatiza a problemática da evasão rural, agravada pelo envelhecimento, propiciando, entre outros aspectos, a redução da força de trabalho familiar e, consequentemente, a incerteza de uma perspectiva futura positiva no que tange à reprodução socioeconômica no assentamento. Atrelada a isso, verificou-se a presença de idosos aposentados em todas as famílias, que fazem uso da PSR como uma estratégia essencial para a sua sobrevivência, persistência e manutenção no campo. É explícita a necessidade de intervenções por parte de instituições governamentais no assentamento para que juntos (comunidade e poder público) possam revitalizar o espaço, ampliando o espectro de oportunidades aos moradores, tornando-o, sobretudo, mais atrativo (viável) aos jovens.
Sustainablity in Higher Education: Strategies, Performance and Future Challenges
Authors: Wu Yiwei
Published: November 2024

Higher education institutions have the responsibility to lead the transformation of thinking through education, promoting a healthier, fairer, and more sustainable world, and playing a crucial role in the development of a sustainable society. The main challenge they face is to promote the principles of sustainability in society while adhering to their traditional missions, and at the same time becoming more sustainable organizations themselves. Over the past three decades, higher education institutions around the world have undertaken numerous sustainable development initiatives and have made significant progress. Sustainability in Higher Education: Strategies, Performance, and Future Challenges aims to provide guidance for higher education institutions in managing and leading sustainable transformation.
SPOD, VUCA, BANI as civilizational characteristics of modernity
Authors: Aref'ev Mikhail Anatol'evich , Zykin Alexey Vladimirovich , Karpichev Evgenii Vladimirovich , Fominih Nataliya Yur'evna
Published: November 2024

The processes of Westernization and globalization unify the social system as a whole, leading it to the most difficult processes for analysis. Inorganic changes in modern society are of particular concern. They primarily touched upon the axiological component of the life of both society and individual existence. In the modern world, saturated with technological changes, globalization and instability, the usual models of perception of reality are insufficient to understand and adapt to new realities, some have come to symbolize the evolution of our perception of the modern world and, following the classics of the civilizational approach to the history of mankind, give reason to talk about a completely new coordinate system and the development of society. Scientific and technological progress continues to move inexorably forward. Thanks to him, technologies are developing so fast that their generations are changing at an increased rate. The growth of computing power, digitalization, the Internet and the development of information technologies have led and continue to lead to a historical "explosion of information". The concept of "information society" has appeared. The world is becoming less stable, less predictable and full of contradictions. Society is changing against the background of the global economic crisis, trade conflicts, sanctions and military conflicts, deglobalization, pandemic, changes and restructuring of logistics networks, the fourth industrial revolution and the transition to a new economic order. The world is becoming less stable, less predictable and full of contradictions. Society is changing against the background of the global economic crisis, trade conflicts, sanctions and military conflicts, deglobalization, pandemic, changes and restructuring of logistics networks, the fourth industrial revolution and the transition to a new economic order. All this leads to an increase in the complexity and diversity of the modern world. In this article, we will consider this possibility and its significance, and also take the liberty to identify and substantiate the characteristics of the modern type of civilization. The considered problem of the civilizational characteristics of modernity is one of the most important for modern reality, being a tool for the formation of modern cultural codes of nations and ethnic groups, which directly reflects the systemic complexity of the modern civilizational structure and requires the use of an interdisciplinary approach and convergent knowledge in understanding and practical solution of the socio-cultural challenges of today.
Dronecage: A Model for Conflict Resolution in Aerial Corridor Intersections
Authors: Nagrare Samiksha Rajkumar , Ghose Debasish
Published: November 2024

With the growth of uncrewed aerial vehicle (UAV) traffic, increasing congestion is expected in low-altitude airspace and should be addressed by modern UAV traffic management (UTM) systems. This surge in the density of UAVs poses a significant challenge in regulating UAV traffic effectively to prevent potential collisions. This work addresses the problem of UAV conflicts in the shared airspace, namely, intersection volume specific to the multilane UAV corridors. The intersection volume is modeled as a “dronecage” structure containing horizontal and vertical geofenced corridors. This structure connects the corridor lanes through the geofenced corridor geofences inside the dronecage to effectively direct UAV motion while maintaining safety and enabling conflict-free operation. An approach vector-based guidance logic is proposed that allows UAVs to move along a direction vector pointed toward the exit lane of the UAV and also avoid conflicts with other UAVs at the intercross with the help of an action set. We define conflict cases and present an analysis of the terminal conditions and time delay analysis. The simulation results show the applicability of the algorithm to various cases with a large number of UAVs, successfully resolving the conflicts by generating a solution within a very short time.
Integration of Electric Drive Systems in ICE to EV Conversion: A GT-Suite Approach
Authors: Setiawan Yosua , Farid Mohd
Published: November 2024

This study was focus on converting internal combustion engine (ICE) vehicles to electric vehicles (EVs) using GT-Suite simulations, focusing on the integration of electric drive system. With increasing global CO2 emissions, many nations aim to achieve carbon neutrality, making the shift to electrification crucial. While new battery electric vehicles (BEVs) produce significantly lower greenhouse gas (GHG) emissions, the high costs associated with new EV production remain a barrier to widespread adoption. Thus, converting existing ICE vehicles into EVs emerges as a more cost-effective and environmentally beneficial strategy. Using Toyota Avanza as a base model, replacing the ICE with a Synchronous AC motor and a LiFePO4 battery pack. Simulation results indicate competitive performance, with a 0-100 km/h acceleration time of 14 seconds, a top speed of 190 km/h, and an estimated driving range of 310 km. This study demonstrates that ICE-to-EV conversions can accelerate the transition to sustainable transportation.
Comment on “Which Portion of Physiotherapy Treatments’ Effect Is Not Attributable to the Specific Effects in People With Musculoskeletal Pain? A Meta-analysis of Randomized Placebo-Controlled Trials” by Ezzatvar et al
Authors: Saueressig Tobias , Dunning James , Mourad Firas , Bliton Paul , Young Ian
Published: November 2024

Letter to the Editor-in-Chief in response to JOSPT article “Which Portion of Physiotherapy Treatments’ Effect Is Not Attributable to the Specific Effects in People With Musculoskeletal Pain? A Meta-analysis of Randomized Placebo-Controlled Trials” by Ezzatvar et al

J Orthop Sports Phys Ther 2024;54(12):783-784. doi:10.2519/jospt.2024.0201
Response to Comment on “Which Portion of Physiotherapy Treatments’ Effect Is Not Attributable to the Specific Effects in People With Musculoskeletal Pain? A Meta-Analysis of Randomized Placebo-Controlled Trials” by Ezzatvar et al
Authors: Ezzatvar Yasmin , Dueñas Lirios , Balasch-Bernat Mercè , Lluch-Girbés Enrique , Rossettini Giacomo
Published: November 2024

Author response to the JOSPT Letter to the Editor-in-Chief “Comment on “Which Portion of Physiotherapy Treatments’ Effect Is Not Attributable to the Specific Effects in People With Musculoskeletal Pain? A Meta-Analysis of Randomized Placebo-Controlled Trials” by Ezzatvar et al”

J Orthop Sports Phys Ther 2024;54(12):784-785. doi:10.2519/jospt.2024.0201-R
Prioritizing Knowledge User Engagement: Engaging Patients and the Public in Creating Enduring Musculoskeletal Rehabilitation Research
Authors: Bullock Garrett S. , Fallowfield Joanne , Fisher Ben , Whittaker Jackie L. , Gafari Olatundun , Bilzon James L. J.
Published: November 2024

SYNOPSIS: To improve the potential for sustained success when implementing injury prevention programs, researchers must focus on patient and public involvement and engagement. Creating lasting equitable relationships between researchers and knowledge users (ie, improving patient and public involvement and engagement) takes time and purposeful investment. Researchers must prioritize, embrace, and integrate patient and public involvement and engagement as a dynamic and continuous social process, unique to each community setting; it is not a one-off checkbox. Recognizing that knowledge users across disciplines and settings are not passive scientific consumers, but active knowledge creators, begins the process of developing equitable partnerships. In this editorial, we highlight the importance of (1) equity in sport and orthopaedic medicine, (2) prioritizing patient and public involvement and engagement at all stages of the research process, and (3) focusing on a knowledge user-centered perspective when designing, analyzing, implementing, and subsequently evaluating musculoskeletal injury prevention programs. J Orthop Sports Phys Ther 2024;54(12):743-747. Epub 11 November 2024. doi:10.2519/jospt.2024.12668
УРОВЕНЬ АДАПТАЦИОННОГО ПОТЕНЦИАЛА ПО Р.М. БАЕВСКОМУ У ЮНОШЕЙ, ПОСТУПИВШИХ В ПРОФИЛЬНЫЕ ВУЗЫ ИЗ ГОРОДОВ И СЕЛЬСКИХ ПОСЕЛЕНИЙ
Authors: Н.Я. Прокопьев , В.Н. Ананьев , Е.В. Быков , В.В. Зебзеев , В.Б. Рубанович , Е.А. Ветошкина , О.В. Лимаренко , С.В. Романова , О.В. Ананьева , Е.С. Гуртовой
Published: November 2024

В статье представлены результаты изучения уровня адаптационного потенциала (АП, у.е.) по Р.М. Баевскому у 385 юношей 18,2 ± 0,8 лет, поступивших в восемь профильных вузов России из городов и сельских поселений. Цель исследования: сравнить уровень АП юношей, проживавших до поступления в вузы в различных городах и сельских поселениях страны. Материал и методы. Методом случайной выборки обследовано 385 юношей выпускников общеобразовательных школ России 18,2 ± 0,8 лет, поступивших для продолжения образования на первый курс в восемь профильных вузов страны из городов и сельских поселений. Оценка АП проведена по методике Р.М. Баевского.
ВЛИЯНИЕ БАКТЕРИЙ, СТИМУЛИРУЮЩИХ РОСТ РАСТЕНИЙ, НА ОСТАТОЧНОЕ СОДЕРЖАНИЕ В ПОЧВЕ МЕТСУЛЬФУРОН-МЕТИЛА
Authors: М.Д. Бакаева , С.Н. Стариков , А.А. Кенджиева , Д.В. Четверикова , С.П. Четвериков
Published: November 2024

Исследовано влияние ризосферных бактерий, обладающих комплексом агрономически полезных свойств, на разрушение в почве гербицида на основе метсульфурон-метила. Показано, что на 21 сутки после обработки культурой бактерий остаточное содержание гербицида в черноземе было на 55-75 % ниже, чем в необработанной почве. Сопоставимый позитивный эффект наблюдался также после интродукции бактерий в почву с высаженными растениями пшеницы. Более быстрое разрушение метсульфурон-метила в почве сопровождалось снижением ее токсичности для чувствительных к гербициду сельскохозяйственных растений, таких как рапс и свекла.
ОСОБЕННОСТИ РАСТИТЕЛЬНОГО ПОКРОВА КОРЕННОГО БЕРЕГА ИРТЫША (ТОБОЛЬСКИЙ РАЙОН)
Authors: Е.И. Попова
Published: November 2024

Коренной берег реки Иртыш представлен склонами различной крутизны в основном юго-западной и южной экспозиции. Рельеф территории представляет собой сочетание разных равнин, которые именуются ярусами, ступенями, геоморфологическими уровнями рельефа и террасами. На коренном берегу Иртыша, в пределах Тобольского района, выявлены следующие ассоциации: Pinetum Rubicosum, Alnetum Filipendulo - Matteusum, Inuletum Phlomondosum, Pimpinelum Leucanthemosum, Artemisetum Veronicosum, Caretum Fragariosum сообщество. Анализ видового состава подтвердил значение коренного берега реки как основных путей миграции видов различного происхождения.
ФАКТОРЫ, ВЛИЯЮЩИЕ НА ДИНАМИКУ ЧИСЛЕННОСТИ КРОВОСОСУЩИХ КОМАРОВ СЕМЕЙСТВА CULICIDAE НА ТЕРРИТОРИИ СЕВЕРНОГО КАВКАЗА
Authors: С.С. Гаджиева , Т.М. Джамалутдинова , Д.Г. Джаруллаев , З.М. Джахбарова
Published: November 2024

Цель. Главной целью исследования является изучение воздействия различных факторов среды на синхронное модифицирование численности кровососущих комаров района исследования. Методы. В исследовательской работе применяли общепринятый метод сбора личинок водным сачком. Численность взрослых особей определяли в экземплярах на 1 м2. Преимагинальные фазы комаров учитывали в контрольных водоёмах различного типа при помощи фотокюветы размером 20 х 25 см с пересчётом в экземплярах на 1 м2 гидрофитной поверхности через каждые четыре дня на течении всего сезона. Выловленные личинки помещались в пробирки с 96% спиртом IV возраста, туда же погружалась этикетка с указанием года, месяца, числа, места сбора и температуры воды. Постоянные препараты комариных личинок готовились по методике, предложенной в [13]. Обсуждение. Результаты проведенного исследования в Северном Кавказе показали, что синхронные изменения численностей различных видов кровососущих комаров, характеризующиеся весьма высокими значениями коэффициентов корреляции, показывают сходное воздействие комплекса экологических факторов на этот процесс. Выводы. Высокая плотность населения способствует поддержанию плотности кровососущих комаров в Северном Кавказе. Неправильное проведенные хозяйственные работы населением приводить к существенному повышению численности кровососущих комаров в регионе.
КУЛЬТУРА БЕЗОПАСНОСТИ ЖИЗНЕДЕЯТЕЛЬНОСТИ У ОБУЧАЮЩИХСЯ ОБЩЕОБРАЗОВАТЕЛЬНОГО УЧРЕЖДЕНИЯ
Authors: С.К. Сарыг
Published: November 2024

Сущность культуры безопасности жизнедеятельности заключается в подготовленности человека к безопасной деятельности, уровне знаний, умений и навыков, являющихся основой снижения рисков и опасных ситуаций. Определение уровня понимания культуры безопасного поведения учащихся в современном социуме показала доминирование среднего уровня сформированности культуры безопасности у обучающихся.
Accurate Lattice Free Energies of Packing Polymorphs from Probabilistic Generative Models
Authors: Olehnovics Edgar , Liu Yifei Michelle , Mehio Nada , Sheikh Ahmad , Shirts Michael , Salvalaglio Matteo
Published: November 2024

Finite-temperature lattice free energy differences between polymorphs of molecular crystals are fundamental to understanding and predicting the relative stability relationships underpinning polymorphism, yet are computationally expensive to obtain. Here, we implement and critically assess machine-learning-enabled targeted free energy calculations derived from flow-based generative models to compute the free energy difference between two ice crystal polymorphs (Ice XI and Ic), modelled with a fully flexible empirical classical force field. We demonstrate that even when remapping from an analytical reference distribution, such methods enable a cost-effective and accurate calculation of free energy differences between disconnected metastable ensembles when trained on locally ergodic data sampled exclusively from the ensembles of interest. Unlike classical free energy perturbation methods, such as the Einstein crystal method, the targeted approach analysed in this work requires no additional sampling of intermediate perturbed Hamiltonians, offering significant computational savings in the system sizes compared in this work. To systematically assess the accuracy of the method, we monitored the convergence of free energy estimates during training by implementing an overfitting-aware weighted averaging strategy. By comparing our results with ground-truth free energy differences computed with the Einstein crystal method, we assess the accuracy and efficiency of two different model architectures, employing two different representations of the supercells degrees of freedom (Cartesian vs. quaternion-based). We conduct our assessment by comparing free energy differences between crystal supercells of different sizes and temperatures and assessing the accuracy in extrapolating lattice free energies to the thermodynamic limit. While at low temperatures and in small system sizes, the models perform with similar accuracy, we note that for larger systems and high temperatures, the choice of representation is key to obtaining generalisable results of quality comparable to that obtained from the Einstein crystal method. We hope the current work to be a useful stepping stone towards efficient free energy calculations in larger, more conformationally flexible systems.
Temperature influence on the deposition of nitrogen-doped SiC polycrystalline films
Authors: Gavalas Michalis , Greenhorn Scott , Mercier Frederic , Zekentes Konstantinos
Published: November 2024

Polycrystalline nitrogen doped cubic silicon carbide (3C-SiC) thin films, are grown on 2” Si wafers by low-pressure chemical vapor deposition (LPCVD) technique with the aim to be used as support and active material in microelectronic devices for neural interfaces. The effect of deposition temperature on the structural, mechanical and electrical properties is investigated. Growth rate is varying from 1 μm/h to 14 μm/h, along with the deposition temperature. We show that the structural and electrical properties of polycrystalline SiC are modified when changing the deposition temperature. Films with resistivity as low as (10.0 ± 0.5) mΩ·cm, low residual stress of (-397 ± 158) MPa and low root mean square surface roughness of (53 ± 19) nm are achieved. Accelerated aging tests in heated phosphate buffer solution (PBS) show an etching rate less than 1 nm/day and a steady low electrical resistivity for 77 days indicating that the nitrogen-doped polycrystalline SiC is a chemically stable material, capable of chronic stability in a saline electrolyte.
Direct Electrochemical Conversion of Carbon Dioxide into Methanol in Water with High Faradaic Efficiency by Mo-Functionalized Electrode
Authors: Nervi Carlo , Barbero Alice , Pezzano Federico , Calderaro Federico , Gobetto Roberto , Reviglio Chiara , Porceddu Asia , Nikitina Victoria , Li Jian-Feng , Zhang Hua , Huang Zhuo , Liu Jia , Oganov Artem
Published: November 2024

We developed a new electrocatalysts for hybrid homogeneous / heterogeneous conversion of CO2 in water. A Molybdenum-based organometallic compound has been linked by covalent C-C bond to a carbon-cloth electrode surface. This technique allows using the Mo catalyst in water, a solvent in which the catalyst is not soluble, for the direct electrocatalytic conversion of CO2 to methanol. Although the system displays moderate current density (1÷4 mA/cm2), the very high faradaic efficiency of the CO2-to-methanol conversion (65%), the good selectivity (H2 is the only other reduction product), the simply experimental setup and the potential industrial scale-up of the technique makes this approach of great interest. Chronoamperometric measurement carried in water for 21 hours show a stable and constant catalytic performance with no other carbon-reduced products. Spectroelectrochemistry and detailed DFT calculations shed light on the catalytic process, which consists of six protons coupled electron transfer (PCET) steps. We propose the catalytic cycle that converts CO to methanol in which the first step is a PCET localized on the CO coordinated to the metal.
Proton first: rationalizing a proton transfer in a protein-fragment complex
Authors: Vatheuer Helge , Johannknecht Lisa , Ziora Rebecca Maria , Keller Gerald , Paulus Jonas , Stelzl Lukas , Czodrowski Paul
Published: November 2024

We present a combination of experimental and theoretical approaches to decipher the molecular recognition event of benzoic acid complexed with Protein Kinase A. The publicy known crystal structure suggests the protonated form of benzoic acid to be complexed with Protein Kinase A. Such a protonation pattern of is unlikely for benzoic acid in aqueous enviromnent and must be induced by complexation to Protein Kinase. Unfortunately, isothermal titration calorimetry does not reveal any binding event which might be caused by the low affinity. However, Poisson Boltzmann calculations and molecular dynamics simulations strengthen the initial hypothesis.
Dinitroacetylene: Can it be Made?
Authors: Harter Lara , Rahm Martin , Bélanger-Chabot Guillaume
Published: November 2024

With a predicted record heat formation, energy density, and an outstanding performance as a rocket propellant, dinitroacetylene stretches the imagination for what is possible in terms of organic chemical explosives and monopropellants. In this study, we employ quantum chemical methods to predict its thermodynamic properties, ionization potential, electron affinity, UV/Vis spectra, NMR, and vibrational spectra, and to investigate proposed decomposition mechanisms. While unimolecular decomposition pathways are predicted to have high activation energies, NOx radical species – commonly present in reaction mixtures of energetic materials – are found to significantly catalyze the decomposition of dinitroacetylene. This catalytic effect may explain previous unsuccessful synthesis attempts. A frontier orbital analysis suggests that partial reduction could increase C–N bond order, offering a strategy to stabilize this elusive high-energy-density material.
Acceleration with Interpretability: Surrogate Model Based Collective Variable for Enhanced Sampling
Authors: Chatterjee Sompriya , Ray Dhiman
Published: November 2024

Most enhanced sampling methods facilitate the exploration of molecular free energy landscapes by applying a bias potential along a reduced dimensional collective variable (CV) space. The success of these methods depends on the ability of the CVs to follow the relevant slow modes of the system. Intuitive CVs, such as distances or contacts, often prove inadequate, particularly in biological systems involving many coupled degrees of freedom. Machine learning algorithms, especially neural networks (NN), can automate the process of CV discovery by combining a large number of molecular descriptors and often outperform intuitive CVs in sampling efficiency. However, their lack of interpretability and high cost of evaluation during trajectory propagation make NN-CVs difficult to apply to large biomolecular processes. Here, we introduce a surrogate model approach using lasso regression to express the output of a neural network as a linear combination of an automatically chosen subset of the input descriptors. We demonstrate successful applications of our surrogate model CVs in the enhanced sampling simulation of the conformational landscape of alanine dipeptide and chignolin mini-protein. In addition to providing mechanistic insights due to their explainable nature, the surrogate model CVs showed a negligible loss in efficiency and accuracy, compared to the NN-CVs, in reconstructing the underlying free energy surface. Moreover, due to their simplified functional forms, these CVs are better at extrapolating to unseen regions of the conformational space, e.g., saddle points. Surrogate model CVs are also less expensive to evaluate compared to their NN counterparts, making them suitable for enhanced sampling simulation of large and complex biomolecular processes.