bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of Fractional Factorial Design for the Selection andScreening of Appropriate Components of a Self-nanoemulsifyingDrug Delivery System Formulation
Authors: Kuncahyo Ilham , Choiri Syaiful , Fudholi Achmad , Martien Ronny , Rohman Abdul
Published: November 2019

Purpose: Recently, a self-nanoemulsifying drug delivery system (SNEDDS) has showngreat improvement in the enhancement of drug bioavailability. The selection of appropriatecompositions in the SNEDDS formulation is the fundamental step towards developing asuccessful formulation. This study sought to evaluate the effectiveness of fractional factorialdesign (FFD) in the selection and screening of a SNEDDS composition. Furthermore, the mostefficient FFD approach would be applied to the selection of SNEDDS components.Methods: The types of oil, surfactant, co-surfactant, and their concentrations were selected asfactors. 26 full factorial design (FD) (64 runs), 26-1 FFD (32 runs), 26-2 FFD (16 runs), and 26-3 FFD(8 runs) were compared to the main effect contributions of each design. Ca-pitavastatin (Ca-PVT)was used as a drug model. Screening parameters, such as transmittance, emulsification time,and drug load, were selected as responses followed by particle size along with zeta potentialfor optimized formulation.Results: The results indicated that the patterns of 26 full FD and 26-1 for both main effects andinteractions were similar. 26-3 FFD lacked adequate precision when used for screening owing tothe limitation of design points. In addition, capryol, Tween 80, and transcutol P were selected tobe developed in a SNEDDS formulation with a particle size of 69.7 ± 5.3 nm along with a zetapotential of 33.4 ± 2.1 mV.Conclusion: Herein, 26-2 FFD was chosen as the most efficient and adequate design for theselection and screening of SNEDDS composition. The optimized formulation fulfilled therequirement of a quality target profile of a nanoemulsion.
Immunomodulatory Activities of Sambucus javanica Extracts in DMBAExposedBALB/c Mouse
Authors: Putra Wira Eka , Rifa'i Muhaimin
Published: November 2019

Purpose: Accumulating evidence shows the genus of Sambucus exerts a broad spectrum ofmedicinal potencies such as anticancer, antiviral, antibacterial, and antidiabetes. Based on theprevious studies, we hypothesized that bioactive compounds of Sambucus might alter severalbiological systems, including the immune system. Therefore, this study extensively aimed toevaluate the immunomodulatory activities of Sambucus javanica extracts in 7,12-dimethylbenz[a]anthracene (DMBA)-treated BALB/c mouse.Methods: The experimental mice were orally administrated with 2.8 mg.kg-1 BW of DMBA forten times within a month. After that, the mice were treated by S. javanica berries and leavesextracts for 2 weeks. Subsequently, the inflammation rate was evaluated by using flow cytometryanalysis, whereas the necrosis incidences were observed by hematoxylin & eosin staining.Results: Based on the results, we found the expression of tumor necrosis factor alpha (TNF-α)and interferon gamma (IFN-ɣ) were increased however after treated by S. javanica berries andleaves extracts were significantly decreased. In the same way, necrosis incidence was increasedin the DMBA-treated group however it was diminished with S. javanica extracts treatment.Conclusion: Together, these results suggested that S. javanica extracts have immunomodulatoryactivities to suppress inflammation and reduce necrosis incidence in experimental mice.
­­­Successful Application of Whole Cell Panning for Isolation of PhageAntibody Fragments Specific to Differentiated Gastric Cancer Cells
Authors: Nikfarjam Sepideh , Tohidkia Mohammad Reza , Mehdipour Tayebeh , Soleimani Ramin , Rahimi Ali Akbar Rahim , Nouri Mohammad
Published: November 2019

Purpose: Generation of antibodies which potentially discriminate between malignant andhealthy cells is an important prerequisite for early diagnosis and treatment of gastric cancer(GC). Comparative analysis of cell surface protein landscape will provide an experimental basisfor biomarker discovery, which is essential for targeted molecular therapies. This study aimedto isolate phage-displayed antibody fragments recognizing cell surface proteins, which weredifferentially expressed between two closely related GC cell lines, namely AGS and MKN-45.Methods: We selected and screened a semisynthetic phage-scFv library on AGS, MKN-45, andNIH-3T3 cell lines by utilizing a tailored selection scheme that was designed to isolate phagescFvsthat not only recognize the differentiated AGS cells but also distinguish them from NIH-3T3 fibroblasts and the poorly differentiated MKN-45 cells.Results: After four rounds of subtractive whole cell panning, 14 unique clones were identifiedby ELISA screening and nucleotide sequencing. For further characterization, we focused on fourphage-scFvs with strong signals in screening, and their specificity was confirmed by cell-basedELISA. Furthermore, the selected phage-scFvs were able to specifically stain AGS cells with38.74% (H1), 11.04% (D11), 76.93% (G11), and 69.03% (D1) in flow cytometry analysis whichsupported the ability of theses phage scFvs in distinguishing AGS from MKN-45 and NIH-3T3cells.Conclusion: Combined with other proteomic techniques, these phage-scFvs can be applied tomembrane proteome analysis and, subsequently, identification of novel tumor-related antigensmediating proliferation and differentiation of cells. Furthermore, such antibody fragments canbe exploited for diagnostic purposes as well as targeted drug delivery of GC.
In Vitro Assessment of Cytokine Expression Profile of MCF-7 Cells inResponse to hWJ-MSCs Secretome
Authors: Mirabdollahi Mansoureh , Haghjooy Javanmard Shaghayegh , Sadeghi-Aliabadi Hojjat
Published: November 2019

Purpose: Several attempts have been made to identify the mechanisms by which mesenchymalstem cells (MSCs)-derived secretome exert anti-tumor or tumorigenic effects, but still furtherinvestigations are needed to explore this subject. Thus, in this study we want to examine theexpression of different cytokines in secretome of hWJ-MSCs and their effects on cytokineexpression profile of the MCF-7 tumor cells.Methods: The hWJ-MSCs were isolated and characterized according to the International Societyfor Cellular Therapy criteria. Then, secretome of hWJ-MSCs was collected and freeze-dried, and20 mg/mL of the freeze-dried secretome was used to treat MCF-7 cancer cells for 48 hours.Afterwards, the expression levels of 12 cytokines including IL-1a, IL-1b, IL-2, IL-4, IL-6, IL-8,IL-10, IL-12, IL-17A, TNFα, IFNγ and GM-CSF in secretome of hWJ-MSCs alone as well as insupernatant of tumor cells before and after treatment with hWJ-MSCs secretome were evaluated.Results: Our results indicate that MCF-7 cells express significant amount of IL-6 and IL-8.Moreover, significant amounts of IL-1a, IL-1b, IL-8, IL-6 and GM-CSF were detected in secretomeof hWJ-MSCs. Furthermore, IL-1a, IL-2 and IL-4 were expressed significantly by MCF-7 cellsafter their treatment with hWJ-MSCs-derived secretome.Conclusion: According to our findings, the hWJ-MSCs derived secretome contains differentcytokines which can exert either anti-tumor or tumorigenic effects.
Cloning and Overexpression of Strictosidine β-D-Glucosidase GeneShort Sequence from Catharanthus Roseus in Escherichia coli
Authors: Arafa Ahmed Saeed , Ragab Amany Elsayed , Ibrahim Abdel-Rahim Sayed , Abdel-Mageed Wael Saad , Nasr Mahmoud Emam
Published: November 2019

Purpose: Strictosidine-β-D-glucosidase (SGD) is considered as a key enzyme in the productionof bisindole alkaloids in Catharanthus roseus. The present study illustrated the production of ashort sequence of this enzyme in Escherichia coli without codon optimization.Methods: Strictosidine-β-D-glucosidase (sgd) gene short sequence (1434 bp), which lacksthe conserved sequence KGFFVWS and the localization peptide sequence at the C-terminal,was amplified from cDNA of C. roseus leaves, cloned and expressed in Escherichia coli. Theactivity of the produced protein in cell free lysate was tested using total alkaloid extract of C.roseus leaves.Results: HPLC and LC-MS analysis of the assay mixture revealed the disappearance of thestrictosidine peak.Conclusion: SGD short sequence can be produced in Escherichia coli in active form withoutcodon optimization.
Aloe Vera/Collagen Mixture Induces Integrin α1β1 and PECAM-1Genes Expression in Human Adipose-Derived Stem Cells
Authors: Sigaroodi Faraz , Shafaei Hajar , Karimipour Mohammad , Dolatkhah Mohammad Amin , Delazar Abbas
Published: November 2019

Purpose: Natural biomaterials are a key base in tissue engineering, and collagen, as the maincontent of the extracellular matrix (ECM), is frequently used in tissue engineering. Aloe verahas some therapeutic effects on ulcers, therefore, the use of this natural resource has alwaysbeen considered for improving collagen function. We aimed to evaluate the effect of Aloe vera/Collagen blended on cell viability, cell attachment, and angiogenic potential by determining ofintegrin α1β1 and platelet endothelial cell adhesion molecule (PECAM-1) genes expression inhuman adipose-derived stem cells (hASCs).Methods: In this study, hASCs after harvesting of adipose tissues from abdominal subcutaneousadipose tissue and isolation, were cultured in four groups of control, collagen gel, Aloe veragel, and Aloe vera/collagen blended in vitro environment at 24h and then cell viability wasassessed by MTT (3-(4,5-dimethylthiazol 2-yl)-2,5-diphenyltetrazolium) assay. Integrin α1β1 andPECAM-1 genes expression were evaluated by real-time RT-PCR.Results: The results of MTT showed that the combination of Aloe vera/collagen was retained thecell viability at the normal range and improved it. In real-time RT-PCR results, integrin α1β1 andPECAM-1 gene expression were increased in the Aloe vera/collagen blended group comparedto the control group.Conclusion: For tissue engineering purposes, Aloe vera improves collagen properties in theculture of hASCs by increasing the expression of the integrin α1β1 and PECAM-1 genes.
10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2Arrest
Authors: Rasmussen Andrea , Murphy Kaylee , Hoskin David W.
Published: November 2019

Purpose: Gingerol homologs found in the rhizomes of ginger plants have the potential to benefithuman health, including the prevention and treatment of cancer. This study evaluated the effectof 10-gingerol on ovarian cancer cell (HEY, OVCAR3, and SKOV-3) growth.Methods: Cell growth was measured by MTT assays, flow cytometry was used to assess cellproliferation, cytotoxicity and cell cycle progression, and western blotting was used to measurecyclin protein expression.Results: Ovarian cancer cells that were treated with 10-gingerol experienced a time- anddose-dependent decrease in cell number, which was due to a reduction in cell proliferationrather than a cytotoxic effect. Reduced proliferation of 10-gingerol-treated ovarian cancercells was associated with an increased percentage of cells in G2 phase of the cell cycle anda corresponding reduction in the percentage of cells in G1. Ovarian cancer cells also showeddecreased cyclin A, B1, and D3 expression following exposure to 10-gingerol.Conclusion: These findings revealed that 10-gingerol caused a G2 arrest-associated suppressionof ovarian cancer cell growth, which may be exploited in the management of ovarian cancer.
Opportunities of Telemedicine for Orthopedics and Trauma Surgery
Authors: Nerlich Michael , Herbst Tanja , Ernstberger Antonio , Blaetzinger Markus
Published: November 2019

Today telemedicine, or eHealth, is an important tool in everyday medical life. In all areas, from the preclinical to aftercare, significant improvements in communication structures have been seen in various eHealth options, which have had significant, positive effects on the quality of patient care in orthopedics and trauma surgery. Initially, there were several isolated solutions and many small individual projects; however, there was a lack of interdisciplinary and comprehensive systems in all healthcare fields. The German Trauma Society (DGU) together with the AUC GmbH took the lead and paved the way for a modulated, comprehensive, interface-compatible teleradiology system. Nevertheless, there are still deficits across all sectors which, in the future, will need to be optimized by eHealth methods and systems. Overall, there is an effort towards patient-centered solutions (patient empowerment). In Germany, telemedicine has gradually gained acceptance in various sectors and is being used nationwide. Telemedicine has proven itself, especially in trauma networks.
Pre-travel Health Advice for Patients With Cardiovascular Disease
Authors: Liew Chee Hwui , Flaherty Gerard Thomas
Published: November 2019

Cardiovascular disease (CVD) is the leading cause of death among international travellers. Practitioner knowledge of the effects of CVD on international travel is imperative in order to promote a healthy travel experience. This review aimed to explore the available literature on this topic. The PubMed database was accessed to source relevant literature using combinations of relevant keywords as search terms. Articles were restricted to those published in the English language through March 2019. Of 1726 article records retrieved, 73 relevant papers were examined carefully. The results of this narrative review are related to multiple aspects of CVD and travel. The pre-travel consultation should address issues regarding vaccinations, travel insurance, anticoagulation, and medical devices. Additional vaccines to be discussed include influenza, pneumococcal, and hepatitis B. Patients with CVD should be advised of the need to carry a copy of their ECG, prescription(s), and pacemaker manufacturer’s card. Knowledge of the location overseas of automated external defibrillators and awareness of health risks associated with strenuous adventure activities are important for CVD travellers. Medical tourism for patients with CVD is briefly considered. Space tourism is an emerging category of extreme international travel that requires specialized pre-travel preparation. This narrative review article highlights the gaps in the travel medicine literature in relation to CVD. A strong evidence base for most recommendations is lacking. Future scholarly efforts are warranted to facilitate more robust travel recommendations for CVD patients. No qualitative studies to date have described the experiences of international travellers with CVD.
A Disease Outbreak Prediction Model Using Bayesian Inference: A Case of Influenza
Authors: Mirarabshahi Atefeh Sadat , Kargari Mehrdad
Published: November 2019

Introduction: One major problem in analyzing epidemic data is the lack of data and high dependency among the available data, which is due to the fact that the epidemic process is not directly observable. Methods: One method for epidemic data analysis to estimate the desired epidemic parameters, such as disease transmission rate and recovery rate, is data intensification. In this method, unknown quantities are considered as additional parameters of the model and are extracted using other parameters. The Markov Chain Monte Carlo algorithm is extensively used in this field. Results: The current study presents a Bayesian statistical analysis of influenza outbreak data using Markov Chain Monte Carlo data intensification that is independent of probability approximation and provides a wider range of results than previous studies. A method for estimating the epidemic parameters has been presented in a way that the problem of uncertainty regarding the modeling of dynamic biological systems can be solved. The proposed method is then applied to fit an SIR-like flu transmission model to data from 19 years leading up to the seventh week of the 2017 incidence of influenza. Conclusion: The proposed method showed an improvement in estimating the values of all the parameters considered in the study. The results of this study showed that the distributions are significant and the error ranges are real.
Effects of Community-Based Interventions in Reducing the Obesity and Overweight Rate Among Iranian Women: Using Urban Health Equity Assessment and Response Tool
Authors: Rassam Farzaneh , Khedmat Leila , Khatami Farnaz
Published: November 2019

Introduction: The increasing prevalence of overweight and obesity is one of the most critical issues of urban health. The current study investigated the effects of community-based interventions on modification of overweight and obesity. Methods: A program based on the Urban Health Equity Assessment and Response Tool (Urban HEART) was developed and implemented in 2013-2014. A total of 166 Iranian females aged 15 years or older who were classified as overweight or obese using body mass index (BMI) were randomly selected and gave verbal consent to participate in this study. The intervention was carried out for a duration of 4 months. Results: The mean age of subjects was 43.6±12.2 years. The total number of overweight and obese individuals were 75 (45.2%) and 91 (54.8%), respectively. The mean BMI of the patients before and after the intervention was 30.3±2.7 and 29.4±2.7 kg/m2 , respectively (P < 0.05). Higher education level and greater floor area were recognized as valid predictors for reduced BMI after the intervention (P < 0.001). Conclusion: This study successfully represents the collaborative role of the community in improving health status by reducing overweight and obesity. The Urban HEART provided distinct opportunities for presenting the promising results of interventions to health policymakers and managers so they can adjust macro and micro policies for achieving better community health outcomes.
Long-term Results of Endoscopic Balloon Dilatation for Gastric Outlet Obstruction Caused by Peptic Ulcer Disease
Authors: Zare Ehsan , Raeisi Hadi , Honarvar Behnam , Lankarani Kamran B.
Published: November 2019

BACKGROUND Gastric outlet obstructions (GOO) is a disabling complication of peptic ulcer disease (PUD). The introduction of endoscopic through the scope balloon dilatation (EBD) has eased the management but there are few reports on the long term results of this modality of treatment on patients’ symptoms. METHODS Over a period of 4 years from January 2012 to December 2015 in two major referral hospitals affiliated to Shiraz university, medical endoscopy reports were reviewed retrospectively to identify those who received EBD for the treatment of GOO due to PUD .All of these patients were recalled and their current status were evaluated. RESULTS 22 consecutive patients with symptomatic GOO secondary to benign stricture underwent endoscopic balloon dilatation by a single operator. Of them, 14 had balloon dilatation twice and 6 had ballooning three times. The interval between the first referral and the last follow-up was 25.2 ± 10.3 (min: 4.8 max:43.4) months. The averages of maximum balloon size were 14.4 ± 5 mm in the first session, 14.3 ± 3.1mm in the second session, and 16 ± 2.4 mm in the third session. 73% of the patients had a significant improvement in clinical symptom with two sessions of EBD and did not require repeat dilatation. CONCLUSION EBD is a safe and efficient method in the management of GOO with good long term results.
Queering Pride: Walking Towards a Queer Future in Ireland
Authors: Perryman Georgina
Published: November 2019

The Queer History Walking Tour is an annually recurring event during Dublin’s official Pride festivities. Created and led by the ‘Godfather of Gay,’ Tonie Walsh, the walks seek to extend stories from the Irish Queer Archive (IQA) into the everyday fabric of the city, contributing to a processual queering of Irish heteronormative histories. As an activist form of public pedagogy, the walking tour encourages a relational understanding of queer cultural heritage through mobile, embodied, and emotional interactions. This paper argues that the walking tour works as an anarchive that contributes to a growing, intersectional understanding of LGBTQ+ experiences and queer futures, facilitated by peripatetic practices. In response to pervasive cis-male homonormativity at Pride, Dr Mary McAuliffe, a queer feminist woman, is the latest tour guide who includes historical stories of lesbian women, trans people, and gay men. Through engaging with this diversity of historical experiences, guides signal and support anti-capitalist events organised to critique the corporatisation of Pride and current attitudes towards LGBTQ+ people in Ireland. Trans Pride and Alternative Pride highlight the ongoing physical and structural violence done to LGBTQ+ people through giving voice to intersectional experiences. They connect LGBTQ+ struggles across different timespaces through engaging with Pride as a protest and marching to significant historical sites on meaningful days in LGBTQ+ history. Walking together to significant places, telling stories, and educating one another at these events works to queer Pride by challenging capitalism and its norms,revealing a trajectory that invites us to imagine and participate in an intersectional future of being queer in Ireland.
The Effect of CSR, Tunneling Incentive, Fiscal Loss Compensation, Debt Policy, Profitability, Firm Size to Tax Avoidance
Authors: Lestari Jihan , Solikhah Badingatus
Published: November 2019

The purpose of this research is to analyze the effect of variables of CSR, tunneling incentive, fiscal loss compensation, debt policy, profitability, and firm size on tax avoidance. The population of this research are 143Manufacturing Companies Listed on BEI In 2012-2016. This research used purposive sampling with a sample of 24 companies. The total sample unit is 120 samples. The analytical tool used in this research is multiple linear regressions. The collected data then analyzed with classic assumption test the hypothesis test by means of SPSS 21. The result of this research is tunneling incentive, fiscal loss policy, and profitability have positive and significant effect to tax avoidance. Debt policies have a negative and significant effect on tax avoidance. Meanwhile, CSR and firm size does not affect tax avoidance. Based on the results of the study it can be concluded that only tunneling incentive, fiscal loss compensation, and profitability are able to increase tax avoidance.
El malecu: Una cultura en peligro de extinción
Authors: Espinoza Romero Elvia , Mejía Marín Noemy , Ovares Barquero Sandra
Published: November 2019

Recibido 05 de mayo de 2010 • Aceptado 31 de agosto de 2010 • Corregido 28 de julio de 2011

 

 

El presente artículo versa sobre una de las lenguas indígenas de Costa Rica, el malecu. Esta lengua es una de las que aún se mantienen vivas en el país; no obstante, la comunidad lingüística que la practica, compuesta por menos de 400 personas, tiende a reducirse aceleradamente. Existe un alto riesgo de que en el futuro próximo dicha lengua llegue a desaparecer. El artículo surge como producto de un proyecto de investigación que se plantea la construcción e implementación de estrategias de aprendizaje, que incorporen las costumbres, tradiciones y lengua autóctona de los indígenas malecu; todo esto en el ámbito escolar, para fortalecer la identidad y la cultura de esta población indígena costarricense.
Deslizamientos en carreteras de montaña: Propuesta de cálculo del bloque deslizante
Authors: Picado Juan Antonio
Published: November 2019

Para la determinación de posibles deslizamientos en los taludes que bordean las carreteras, sobre todo aquellas que atraviesan formaciones montañosas, de topografías de altas pendientes, se propone un método seudo estático, para suelos cohesivos puros, basado en la teoría de que ocurre una meteorización producto de la intemperización y de la humedad de la roca superficial de las montañas, y combinando las variables de pendiente, humedad, peso de la cobertura vegetal y del suelo, tanto seco como saturado, para así obtener valores que nos permitan predecir deslizamientos, y que permita mitigar la vulnerabilidad de las zonas susceptibles a ellos, lo que evitaría los accidentes, y un ahorro en tiempo y maquinaria.
Some, But Not All, Children Believe in Miracles
Authors: Harris Paul L. , Corriveau Kathleen H.
Published: November 2019

Recent findings have shown that young children resemble adults in claiming that events which violate causal laws cannot happen. Indeed, young children are especially conservative. They claim that even highly improbable events, such as finding an alligator under one’s bed, cannot happen. Children make use of this knowledge about possibility and impossibility in assessing the status of a narrative. When presented with narratives that include extraordinary or magical possibilities, children typically judge them to be fictional narratives rather than genuinely factual accounts. However, despite their doubts about any radical departure from the ordinary course of events, some young children believe in various extraordinary or miraculous possibilities. They accept that God has special powers, unlike ordinary mortals. In addition, when presented with narratives that include miraculous events, they often claim that the narrative is an account of what truly happened rather than being purely fictional. We discuss the origins and scope of this apparent tension between a naturalistic stance and a belief in the miraculous.
Mechanical flower thinning in peach trees
Authors: Barreto Caroline Farias , Antunes Luis Eduardo Correa , Ferreira Letícia Vanni , Navroski Renan , Benati Jorge Atílio , Pereira José Francisco Martins
Published: November 2019

Abstract In cultivation of peaches, thinning is conventionally performed on fruits by hand, and needs to be done in a short time and with specialized labor, which increases the operational costs of this practice. Mechanical thinning can be an alternative to manual fruit thinning. Thus, the objective of this study was to evaluate the effect of mechanical flower thinning with different equipment in advanced peach orchard. The experiment was conducted in 2016 and 2017, combining advanced selections of peach trees and thinning methods. The evaluated variables were percentage of flowers thinning, thinning time, fruit number per plant, plant production, estimated yield, average fruit mass and fruit diameter class. Flower mechanic thinning alters the yield index of peach trees. Mechanical thinning on peach trees was efficient in flower thinning and reduced the practice execution time. Therefore, mechanical thinning is an alternative to the manual fruit thinning of peach trees.
Ecological anatomy of Eugenia punicifolia (Kunth) DC. (MYRTACEAE) in the restinga region,state of Ceará
Authors: Lemos Viviane de Oliveira Thomaz , Lucena Eliseu Marlônio Pereira de , Bonilla Oriel Herrera , Edson-Chaves Bruno
Published: November 2019

Abstract The species Eugenia punicifolia (Kunth) DC. (myrtle) occurs in the coastal region of the state of Ceará and has ecological and medicinal importance. This study aimed to characterize the leaf anatomy of myrtle (E. punicifolia) in the rainy and dry seasons, as well as in the sun and shade in the restinga region of the state of Ceará and to contribute to the understanding of the morphoanatomic variations in response to the natural conditions of the occurrence of this species. For this, collections of fully expanded leaves were performed at the Botanical Park of Ceará and fixed in FAA70, being replaced by 70% ethanol after 24 hours. The usual anatomical procedures were then performed in order to qualitatively and quantitatively analyze the leaf blade, petiole and epidermis structures. As a result, it was found that myrtle has xeromorphic characteristics such as thick cuticle, hypoestomatic leaf and sclerenchyma fibers in the median vein vascular bundles. It was concluded that E. punicifolia has great plasticity to adjust well under the analyzed conditions.
Avaliação de pacientes vítimas de trauma cranioencefálico com sinais de intoxicação alcoólica.
Authors: Grzelczak Angela Cirlei , Ceccon Andressa , Guetter Camila Roginski , Pimentel Silvania Klug
Published: November 2019

RESUMO Objetivo: avaliar, em vítimas de traumatismo cranioencefálico, a influência da intoxicação alcoólica no tempo para submissão destes pacientes à tomografia de crânio, comparando também os achados tomográficos nos pacientes alcoolizados e não alcoolizados. Métodos: estudo retrospectivo de 183 pacientes com traumatismo cranioencefálico, divididos em dois grupos: 90 alcoolizados e 93 não alcoolizados. Foi calculado o intervalo de tempo desde a chegada do paciente ao pronto socorro até a realização da tomografia para comparação entre os grupos, e analisados os achados tomográficos. Resultados: no grupo alcoolizado, o percentual de pacientes do sexo masculino foi maior, a idade predominante situava-se entre os 31 e os 40 anos, a agressão foi o mecanismo de trauma mais frequente e estes pacientes apresentaram valores mais baixos na escala de coma de Glasgow. Observou-se que não houve diferença estatística entre os dois grupos quanto ao intervalo de tempo para realização de tomografia, bem como, em relação aos achados tomográficos. Além disso, nos pacientes alcoolizados, quando correlacionados os valores da escala de coma de Glasgow com o intervalo de tempo, não houve diferença entre valores de 13 a 15 (traumatismo cranioencefálico leve) e os iguais ou menores do que 12 (traumatismo cranioencefálico moderado e grave). Conclusão: os sinais de intoxicação alcoólica não influenciaram no intervalo de tempo para realização da tomografia. Os pacientes alcoolizados apresentaram escores mais baixos na escala de coma de Glasgow por efeito direto do álcool e não por uma maior prevalência de achados tomográficos.
NOVO NEOLIBERALISMO ACADÊMICO E O ENSINO SUPERIOR NO BRASIL1
Authors: Costa Camila Furlan da , Silva Sueli Maria Goulart
Published: November 2019

RESUMO A implementação de programas e políticas nas universidades públicas brasileiras, nos últimos 15 anos criaram novos mecanismos de integrá-las aos circuitos de reprodução do capital, sem modificar sua natureza jurídica. Em um contexto de aceleração tecnológica e aprofundamento da crise do capital, criaram-se novas formas de apropriação capitalista do conhecimento produzido pelas universidades públicas brasileiras, em todas as suas atividades. Este artigo busca contribuir para a caracterização do novo neoliberalismo acadêmico a partir da análise da articulação entre as políticas de ampliação do acesso e de incentivo à inovação nas universidades públicas brasileiras. O Novo Neoliberalismo acadêmico é um conceito que descreve a exacerbação das características historicamente registradas na mercantilização capitalista no ensino superior. No Brasil, as políticas neoliberais para o ensino superior foram se transformando, adquirindo novas características em função das mudanças nas recomendações dos organismos internacionais. Caracterizamos, assim, o novo neoliberalismo acadêmico como um conjunto de políticas e programas que criam políticas ditas inclusivas; flexibilizam a formação por meio da oferta de novas modalidades de cursos; modificam o financiamento; estabelecem o empreendedorismo como cultura a ser disseminada pela universidade; difundem o gerencialismo; e precarizam as relações de trabalho nas universidades públicas.
NOVO MODELO E VELHOS PROBLEMAS: A CRIAÇÃO DE UM SERVIÇO SOCIAL AUTÔNOMO SOB A ÓTICA DA EFICIÊNCIA1
Authors: Andrade Bruno Henrique Souza de , Gonçalves Andréa de Oliveira
Published: November 2019

RESUMO A pesquisa objetiva analisar os desdobramentos da criação do Instituto Hospital de Base do Distrito Federal (IHBDF) sob a ótica da eficiência do gasto com recursos humanos. Trata-se de uma pesquisa descritiva, com a utilização da Análise Envoltória de Dados (DEA) e a adoção das seguintes variáveis: i) gasto com recursos humanos (GRH); ii) número de cirurgias realizadas (CIR) e iii) número de consultas ambulatoriais realizadas (CSA). A análise abrangeu 240 decision making units (DMUs), que correspondem aos meses observados. Os períodos analisados podem ser segregados em dois grupos: a) modelo tradicional (2008 - 2017), cujos dados foram fornecidos pela Secretaria de Saúde do DF e b) novo modelo (2018 – 2027), o qual abrange os dados projetados. Os resultados evidenciaram que a criação do IHBDF não promove a superação dos denominados velhos problemas, como a ineficiência e a insuficiente oferta de serviços de saúde.
GLOBAL BUZZ: UMA META-ANÁLISE1
Authors: Silva Carla Cristina da , Brandão Marcelo Moll , Guerrazzi Luiz Antônio de Camargo
Published: November 2019

RESUMO O presente artigo propõe uma meta-análise da relação do global buzz, na criação do conhecimento e da inovação. Nos últimos anos houve um aumento substancial de pesquisas que reconhecem que a aquisição de conhecimento de empresas aglomeradas se processa por via de interações deliberadas com outros atores fora da concentração de empresas. Foram identificados 15 estudos científicos, localizados em nove (9) bases de dados (Web of Science, Ebsco, Scopus, Proquest, Emerald, JSTOR, ScienceDirect, Springer, Inspec, Compendt, Google scholar), os quais geraram 30 effect sizes, envolvendo uma amostra acumulada de 39.750 empresas. Sendo proposto um modelo teórico hipotetizado, com base em dois construtos e uma variável moderadora. Os resultados demonstraram uma relação direta e significativa entre global buzz, conhecimento e inovação. Em relação ao efeito moderador, confirmou-se que o tamanho da empresa da aplicação da pesquisa tem uma influência significativa sobre a magnitude dos effect sizes. A contribuição teórica e metodológica proporcionada por esta meta-análise foi no sentido de prover uma revisão consistente que resultou na integração quantitativa dos construtos até então estudados (conhecimento e inovação). Acredita-se que entender a dinâmica local e global de empresas aglomeradas, sob a ótica do aprendizado e desempenho, tem potencial para transformar as visões atuais do campo de estudo e alterar a prática da pesquisa.
LOW EFFICIENCY IN THE USE OF RESEARCH AND DEVELOPMENT RESOURCES IN BRAZILIAN PUBLIC RESEARCH ORGANIZATIONS: CAUSAL CHAINS ANALYSIS1
Authors: Oliveira Fernanda Stringassi de , Bonacelli Maria Beatriz Machado
Published: November 2019

ABSTRACT Open Innovation paradigm brought additional challenges to the already complex Brazilian ST&I scenario of scarce resources and ineffective public policies. The Public Research Organizations (PROs) face obstacles regarding the limitation imposed by their public nature, complex laws and regulations, inadequate technological and organizational structure, and lack of strategy and priority. Besides that, to improve their results and catch up the competitiveness, Research & Development (R&D) projects must be transdisciplinary and collaborative, which usually require a high volume of budget, large teams, and organizational structure for Research Management and Administration (RMA). The low efficiency in the use of physical, financial and human resources are hampering PROs to overcome the financial crisis and backwardness of the national ST&I results. This study aimed to make a deep analysis of this macro problem in the R&D Manager perspective as a social actor, based in the Situational Strategic Planning method. The results evidenced the vastness of the problem and supported the comprehension of the social game in place and the work fronts where the actor could tackle the problem. The main conclusion is that PROs must take into account the capacity building in RMA to leverage results and influence positively the ST&I policy arena.
O EFEITO DA INCERTEZA POLÍTICA NO DESEMPENHO E VALORAÇÃO DAS COMPANHIAS ABERTAS BRASILEIRAS1
Authors: Formiga Márcia , Barros Claudio Marcelo Edwards , Cezário Nathiele de Jesus , Scherer Luciano Marcio
Published: November 2019

RESUMO O objetivo deste trabalho consistiu em examinar o efeito da incerteza política observado no Brasil nos anos de 2014 a 2016 sobre o desempenho econômico e valoração das companhias abertas. Esta pesquisa contribui para a evolução do conhecimento sobre a temática incerteza política, bem como para aprofundar a análise dos resultados apresentados por estudos que buscaram mensurar e demonstrar os efeitos produzidos por um ambiente de elevada incerteza política e como isso é capaz de afetar tanto a economia como as finanças corporativas. Para indicar o período de incerteza política, a pesquisa utilizou os relatórios Global Ratings para América Latina da Standard and Poors emitidos entre 03/2014 e 02/2016. Para determinação do desempenho econômico, as variáveis dependentes do estudo foram ROE, ROA, ROI, EVA e Ebitda. Para valoração, utilizou-se o Q de Tobin, MVA e Price to Book. A amostra foi composta por 4.658 observações de companhias abertas brasileiras para o período entre 2011 a 2016. Utilizou-se estatística descritiva, testes não paramétricos, análise fatorial e regressão múltipla com dados em painel. Alinhado aos estudos prévios e de acordo com o esperado, observaram-se evidências de que o nível elevado de incerteza política alcançou a atividade econômica na forma de queda de desempenho e destruição do valor de mercado de empresas brasileiras. Estes resultados se mostraram robustos à utilização do índice EPU (Economic Policy Uncertainty) proposto por Baker, Bloom e Davidson (2013).
ENDIVIDAMENTO DE OPERADORAS DE PLANOS DE SAÚDE DA MODALIDADE AUTOGESTÃO E REGULAÇÃO DA SAÚDE SUPLEMENTAR1
Authors: Avelar Ewerton Alex , Souza Antônio Artur de , Amaral Hudson Fernandes , Reyes Stephanie Torres
Published: November 2019

RESUMO A pesquisa apresentada neste artigo visou analisar determinantes de endividamento em operadoras de planos de saúde (OPS) da modalidade autogestão, sob a perspectiva da regulação da Agência Nacional de Saúde Suplementar (ANS). Considerando-se a metodologia aplicada, esta pesquisa pode ser classificada como quantitativa e causal. A amostra considerou OPS da modalidade de Autogestão que apresentaram seus dados financeiros ao longo do período de estudo (2010 a 2016), publicamente no site da ANS. Foram empregados, essencialmente, dados secundários financeiros e operacionais. Após a coleta e o tratamento dos dados, foram aplicadas as seguintes técnicas: análise documental, estatística descritiva e a análise de regressão com dados em painel. Verificou-se que algumas das variáveis clássicas empregadas em estudos sobre determinantes do endividamento corporativo foram consideradas significantes. No que se refere às variáveis relacionadas à regulação, muitas se mostraram significantes em relação ao endividamento geral e ao de longo prazo. A principal variável de regulação observada foi a relacionada à proporção de planos antigos da operada (ANT). Também foram consideradas significantes as variáveis relacionadas ao porte (TAM), à idade média dos beneficiários (IDA) e à região de atuação (CDR3). Destaca-se que a significância das variáveis dependeu do horizonte temporal abordado (curto ou longo prazo).
A RELAÇÃO ENTRE INVESTIMENTO EM PROPAGANDA E O VALOR DA FIRMA: UMA REVISÃO SISTEMÁTICA E UMA AGENDA DE PESQUISA PARA FUTUROS ESTUDOS 1
Authors: Frio Ricardo Saraiva , Glasenapp Thiago dos Santos , Silveira Rodrigo Heldt , Luce Fernando Bins
Published: November 2019

RESUMO Um desafio aos profissionais e pesquisadores de marketing é demonstrar o impacto de suas ações no valor das empresas. O alto investimento das organizações em propaganda gera necessidade de demonstrar os benefícios financeiros dos esforços e investimentos neste instrumento de marketing. Diante do elevado número de artigos discutindo esse tópico, uma revisão sistemática acerca da relação entre investimento em propaganda e o valor da firma foi conduzida com os objetivos de avaliar os resultados obtidos em diferentes categorias temáticas acerca do tópico e avaliar o efeito dos investimentos em propaganda sobre diferentes métricas de valor da firma. Utilizando as bases de dados EBSCO, Google Acadêmico e Web of Science foram buscados artigos publicados entre 1997 e 2019, atingindo, assim, uma base final de 43 artigos para avaliação. Os resultados evidenciam majoritariamente efeitos positivos da comunicação no valor da firma, embora alguns resultados contraditórios também tenham sido encontrados. Variáveis com potencial para afetar essa relação também foram observadas, tais como cultura, setor e tamanho da empresa. Adicionalmente, foi possível identificar uma escassez de estudos brasileiros sobre o tema. Por fim, propôs-se uma agenda para pesquisas futuras a fim de se obter maiores avanços nos estudos acerca do tema.
A CONSTRUÇÃO COTIDIANA DA GREVE NA UFRGS: O MOVIMENTO CONTRA AS REFORMAS NO FINAL DE 20161
Authors: Mortari André Dias
Published: November 2019

RESUMO Na segunda metade de 2016, vários acontecimentos movimentaram o cotidiano dos trabalhadores de todo o Brasil. Na Universidade Federal do Rio Grande do Sul (UFRGS), técnicos-administrativos em educação e docentes deflagraram greves em oposição a então chamada PEC do Fim do Mundo e a Reforma do Ensino Médio. Participando ativamente destes movimentos e, ao mesmo tempo no fazer acadêmico estudando a obra de Henri Lefebvre, foi inevitável aproximar estes fazeres, organizando uma pesquisa-militante com o objetivo de analisar a construção cotidiana destes movimentos grevistas. O estudo da greve, através da vida cotidiana – este lugar de transição, encontros, interações e conflitos, permite compreender a sua construção desde baixo, a partir do vivido e do viver, do individual e do coletivo. Além disto, destacam-se as ações e práticas que suspendiam a repetição e desafiavam a alienação.
COMUNALIDAD Y TRANSMODERNIDAD EN LAS PRÁCTICAS ORGANIZATIVAS DE LA RED DE HUERTOS EDUCATIVOS EN MÉXICO 1
Authors: Pabello Giovanna Mazzotti , Nasupcialy Kay Nicté Nava
Published: November 2019

RESUMEN Este trabajo tiene como objetivo proponer una ruta crítica de análisis sobre las formas de conocimiento y las prácticas organizativas de colectivos sociales autónomos con principios comunitarios que subsisten en espacios urbanos. Se retoma la propuesta crítica de la colonialidad epistémica a la teoría de la organización y al paradigma administrativo/management y se suma a la invitación para generar saberes organizacionales de América Latina que se alejen de la abstracción del artificio organizacional que supone la teoría en la que se sostiene la modernidad. Como propuesta se incorpora la noción de transmodernidad y las nociones de ámbitos de comunidad, comunalidad y pedagogía de la comunalidad para dar cuenta de los principios articuladores que organizan las prácticas del colectivo independiente la Red de Huertos Educativos y Comunitarios de Xalapa (RHEC), Veracruz, México, que está enfocado en el intercambio de experiencias y aprendizajes generados a partir del trabajo en los huertos agroecológico.
Condições de saúde bucal da população indígena guarani moradora no Sul do Brasil
Authors: Baldisserotto Julio , Ferreira Alexandre Moreira , Warmling Cristine Maria
Published: November 2019

Resumo Introdução A saúde bucal das populações indígenas brasileiras foi historicamente negligenciada. Recentemente tem sido dada atenção especial por meio da Política Nacional de Saúde Bucal Indígena. No entanto, muito pouco ainda se sabe a respeito da realidade epidemiológica bucal dessas populações, em especial no Sul do Brasil. Objetivo Investigar a situação de saúde bucal dos índios guaranis. Método Estudo transversal realizado em 19 aldeias, totalizando 203 sujeitos. Foram utilizados os métodos de pesquisa da OMS. Resultados O CPOD médio aos 12 anos e na faixa etária de 15-19 anos foi de 1,3 e 3,4, respectivamente. Em adultos, a média foi de 11,55, com componente perdido (P) de 69,3%. Entre idosos, o CPOD foi de 18,6. O ceo foi significativamente maior nas mulheres (p < 0,05) aos 5 anos. A presença de cálculo foi a condição periodontal mais prevalente em todas as idades. Entre as crianças, 91% apresentaram padrão normal de oclusão. Padrões aceitáveis de fluorose foram encontrados em 91,4% dos indivíduos do grupo de 15-19 anos. A higiene bucal e o uso de pasta fluoretada foram relatados por 95%. Conclusão A população indígena guarani da região Sul do Brasil apresentou alguns indicadores de saúde bucal melhores do que os relatados no inquérito epidemiológico de saúde bucal de 2010. O CPOD médio em diferentes idades foi menor no povo guarani do que na população em geral. O acesso a itens de higiene bucal e a serviços de saúde pode explicar alguns desses resultados. Esses dados são importantes para o planejamento de ações de saúde para essa população.
Estratégias de Nomeações Ministeriais: entre a política e as políticas públicas
Authors: Palotti Pedro Lucas de Moura , Cavalcante Pedro Luiz Costa
Published: November 2019

RESUMO Introdução: Os ministros são atores políticos centrais na elaboração e implementação de políticas públicas, defesa e representação política de grupos sociais e de interesse, aconselhamento e assessoramento dos chefes de governo, além de exercerem autoridade máxima no campo específico sob sua jurisdição para diversas demandas cotidianas. Nesse contexto, a composição dos gabinetes indica a permeabilidade de aspectos políticos e também de elementos técnicos na condução dos problemas a cargo dos ministérios. Assim, quais os perfis dos ministros recrutados pelos governos eleitos da Nova República, sobretudo, em termos de inserção político-partidária e de expertise técnica? Materiais e Métodos: Para responder essa questão, este artigo propõe a utilização do Índice de Politização Ministerial (IPM) a partir de uma base de dados original dos ministros titulares do governo Collor à interrupção do segundo mandato de Dilma Rousseff (1990 a 2016). Resultados: Como resultado, o trabalho demonstra elevada qualificação do ministro mediano no Brasil democrático, bem como a predominância do perfil que agrega experiências nas arenas política e também técnica. Observam-se também diferenças no padrão de nomeação entre os governos tucanos e petistas. Enquanto os primeiros selecionam mais empresários e especialistas, os governos petistas foram mais politizados e nomearam mais frequentemente empregados, mulheres e negros. Discussão: Em suma, ao agregar na análise dos ministros a perspectiva da trajetória pessoal e a abordagem da composição partidária no contexto do presidencialismo de coalizão, o artigo contribui para qualificar o debate sobre o Executivo e também sobre as diferenças do sistema partidário no Brasil.
MORPHOMETRIC ANALYSIS OF FRUITS AND SEEDS OF Annona crassiflora Mart. (ANNONACEAE) FROM CENTRAL BRAZIL
Authors: Palermo Alexandre Cesar , Souza Anderson Marcos de
Published: November 2019

ABSTRACT With the existing reduction of the vegetation cover of the Cerrado, several tree species have their areas of occurrence diminished, and as a consequence, they lose part of their genetic diversity. To counter this scenario it is necessary to know the genetic diversity in order to base projects and practical conservation measures. Thus, the objective of this work was to investigate the genetic variability of Annona crassiflora by means of morphometric data of fruits and seeds in four populations in central Brazil. In total, 152 fruits were obtained from 73 matrices, of which the height, diameter, fruit mass, mass of 100 seeds and number of seeds per fruit were measured. The fruits were stripped and the seed removed to measure their height, width and thickness. The hierarchical cluster study showed the grouping of 11 small groups and two large groups, and in these two large groups there are representatives of the four populations sampled. This shows that there is no specific division of populations, indicating high genetic variability. The fruits of the Buritis population were, as a rule, significantly larger than those of other populations, which may indicate genetic distancing or different environmental conditions of pollination and dispersion. This pattern was not observed in the seed size analysis, although there was a statistical difference between the populations. In general, the largest dimensions were found in the populations of Planaltina and Buritis. Therefore, the analyzes indicate high genetic diversity and fruits/seeds with larger dimensions in the best-preserved state.