bluuebunny/crossref_metadata_2025 huggingface dataset:
TRANSFORMATION OF HEALTH TERMINOLOGY THROUGH DERIVATIONAL AFFIXATION IN CNN ONLINE NEWS
Authors: Wulandari Sari , Yatmikasari Ika , Sariyati Ice
Published: October 2023

Derivational affixation is a linguistic process that involves the creation of new words by adding prefixes, suffixes, or infixes to existing words. These affixes can modify the word's part of speech, alter its meaning, or both. The present study had the objective of identifying various types of derivational affixes and examining the morphological transformations they bring about in health-related terms within CNN's online news platform. Employing qualitative research methods informed by Katamba's theoretical framework (2005), the investigation utilized a dataset sourced from the news website https://edition.cnn.com/. The dataset encompassed 30 health-related news articles spanning topics such as COVID-19, mental health, food, beauty, sleep, and pregnancy. Based on data analysis from 30 health news, there were 13 words containing derivational prefixes and 64 words containing derivational suffixes. The words in derivational prefix did not change the part of speech but changed the meaning. In derivational suffixes, there are 7 types of changes that change word from verb to noun (23 words), adjective to noun (14 words), noun to noun (10 words), noun to adjective (7 words), adjective to adverb (5 words), verb to adjective (4 words), and the last noun to verb (1 word). From the findings, it can be concluded that the addition of affixes to words explains the function of sentence structure. Derivational suffixes are found the most because they have many interactions of forms, meanings, and functions. Keywords: derivational affix, health, prefix, suffix, news
Effect of sowing windows and nitrogen levels on growth and fodder yield of ryegrass (Lolium multiflorum) under South Eastern Rajasthan
Authors: Meena Harphool , Manoj  , Yadav Rajendra K. , Yadav Shankar Lal , Bairwa R.K. , Bhaskar Madhu Lata , Singh Pratap
Published: October 2023

An experiment conducted at Agricultural Research Station Ummedganj, Kota, Rajasthan during Rabi (2018-19 and 2019-20). The experiment was laid-out in split plot design with four replications having sixteen treatment combinations of four sowing windows (25th October, 05th November, 15th November and 25th November) allocated in main plot and four nitrogen levels (100, 125, 150 and 200 % RDN) in sub plot. Significantly higher leaf weight/10 plants (g) and 10 plant’s stem weight (g) of ryegrass were noted when the sowing occurred on November 05th during first cutting at 45, second cutting at 75, third cutting at 105 and fourth cutting at 135 DAS over sowing of ryegrass on 15th and 25th November, respectively. Ryegrass sown on 05th November had a significantly higher green and dry fodder yield (1184 and 224 q/ha) than sown on 15th and 25th November. However, it was found at par with sown on 25th October sowing (1145 and 220 q/ha).Under 150 % RDN application at 45, 75, 105, and 135 DAS sowing on 5th November, the maximum leaf weight (g) and stem weight (g) of ryegrass were measured over application of 100% RDN and 125% RDN. Application of 150% RDN gave significantly higher green and dry fodder yield (1112 and 202 q/ha) over application of 100 and 125% RDN, but it was found at par with application of 200% RDN (1121 and 205 q/ha) green and dry fodder yield in the pooled analysis.
Communication as an Element of Personal Security
Authors:   John Paul II University of Applied Sciences in Biala Podlaska (Poland), Ciekanowski Zbigniew , Krawczyńska Sylwia ,   Main School of Fire Service (Poland), Nowicka Julia ,   War Studies Academy (Poland), Wyrębek Henryk ,   Siedlce University of Natural Sciences and Humanities (Poland)
Published: October 2023

The study refers to the role of building relations between the direct supervisor and employee teams, indicating the opportunities and threats resulting from conducting selected aspects of internal communication in the so-called uniformed organisations. The authors draw attention to the roles of communication competencies and their social overtones, seeing in these elements both opportunities and threats to the involvement of employees in the performance of official tasks, as well as their readiness to deepen relations with their direct superior. The presented results of empirical research concern the organisation of the Ministry of National Defence and the State Fire Service and are only an element of a larger research project. The aim of the research process was to determine the opportunities and threats generated by aspects of organisational communication in the context of maintaining a satisfactory state of personal security of the examined institutions participating in activities in the field of defence and protection of population, property and the environment.
Clustering of Polish Citizens on the Bases of Their Support for Leaving and Remaining the European Union
Authors:   WSB Merito University in Gdańsk (Poland), Kozłowski Artur Roland , Krzykowski Grzegorz ,   WSB Merito University in Gdańsk (Poland), Fallon Grahame ,   Brunel University (United Kingdom)
Published: October 2023

The article presents the clustering of Polish citizens based on the empirical dimension of support for European integration. The structure of the work is based on three key elements constituting the basis of the presented text. The first refers to the development of a scale to measure the extent of support for the integration of Poland with the EU. The second element covers an area of support scale modelling. After the substantial and statistical analysis of the adequacy of the probability distribution for the support scale, it was decided that a model in which the scale underwent mixing non-standard Beta distributions would be adopted. Applying the Maximal Likelihood Method (ML), the components for its fitted probability densities and estimators of prior (or mixing) probabilities were indicated. The procedure allowed us to define the clusters of which the population of voters was composed. The paper’s final section presents many practical and theoretical conclusions for political parties and scientists interested in the discussed area. The novelty of applying the ML method goes hand in hand with the findings that previously appeared in political science literature, although under different economic and geopolitical conditions.
Benefits and costs of Eurasian integration and reintegration for Russia
Authors: Leskova Irina , Parfenov Denis , Adamskaya Lyubov'
Published: October 2023

In view of the tense geopolitical situation in the world community, the distancing and sanctioning of the «Collective West», the active regionalization of countries in maintaining and developing socio-economic ties, the article attempts to determine the role of the EAEU in the development of Russia within the framework of Eurasian integration and reintegration. Thus, the costs of Russia's participation in these processes, the benefits derived from socio-economic interaction with the participating countries were identified, and possible directions for Russia's development within the framework of Eurasian cooperation were identified. As costs (criticism) of the Eurasian integration and reintegration stand out: cooperation with countries whose total territory is five times smaller than the territory of Russia; whose population is three times smaller than the population of Russia; cooperation with countries with a lower standard of living and no borders with Russia; the presence of a lower GDP growth in Russia in comparison with other EAEU member countries. Along with the costs, a number of benefits are also highlighted, in particular, the possibility of expanding the sales market, increasing the resource base, increasing cooperation and competition between business units between the EAEU member countries, laying new international routes and expanding transport routes, the possibility of forming a common financial market, creating a common payment infrastructure based on digital technologies, which reduces the time and cost of transactions, the formation of new sustainable mutually beneficial cooperation and logistics chains, the implementation of international transactions in national currencies, and subsequently the possibility of promoting the digital ruble as a single currency used within the Union. As a result of the study, it is concluded that the EAEU member countries open the way for Russia to effective and mutually beneficial cooperation, assigning a significant role to the country as a carrier of a model of honest and fair exchange, which takes into account the national interests of each participant, considered as a sovereign state, excluding the colonial and neo-colonial paths.
La investigación basada en el diseño y el desarrollo curricular en la educación en ciencias
Authors: Candela Rodríguez Boris Fernando
Published: October 2023

Este manuscrito tiene como propósito describir los principales elementos epistémicos y metodológicos que subyacen al enfoque de la Investigación Basada en el Diseño y el Desarrollo Curricular. Estos han comenzado a ayudar a disminuir la ruptura existente entre la literatura proveniente del campo de indagación de la educación en ciencias y la práctica educativa. El ciclo iterativo de la Investigación Basada en el Diseño es considerado un enfoque de indagación que, en interacción sinérgica con el ciclo del Desarrollo Curricular, permite comprender cómo, cuándo y por qué un ambiente de aprendizaje de un contenido funciona en un contexto real de aula. Esta comprensión se materializa en la creación de innovaciones educativas y la generación de un conjunto de teorías instruccionales de dominio específico referente a la enseñanza y aprendizaje de un contenido.  Para ello, el investigador/diseñador en cooperación con el profesor de aula, y apoyados en el modelo de razonamientos y acciones pedagógicas, recogen y analizan evidencia empírica de carácter cualitativo y cuantitativo, a fin de llevar a cabo una evaluación formativa y cuantitativa que permita validar los productos de diseño y desarrollo curricular.
Cumhuriyet Döneminde Yetişmiş İki Öncü Sanatçı, Mihri Rasim ve Hale Asaf
Authors: OTO Arzu
Published: October 2023

Osmanlı’dan Cumhuriyet Türkiye’sine geçiş döneminde Hale Asaf (1905-1938) ve Mihri Rasim (Müşfik) (1886-1954) kendilerini sanatçı olarak tarif eden öncü kadınlardır. Saraya yakın, eğitimli bir zümrenin mensubu olduklarından resim ve müzik dersleri alarak eğitim görmüş ve çok dilin konuşulduğu bir çevrede yetişmişlerdir. Mihri Rasim (Müşfik) sanatçı ve eğitmen olarak ikonik bir figürdür. Kendini portre ressamı olarak yetiştiren Mihri İtalya, Fransa ve Amerika’da sanatçı kimliği ile var olmuş, Bernard Shaw, Thomas Edison, Franklin Roosevelt gibi ünlülerin portrelerini yapmış, İnas Sanayi Nefise Mektebi’nin kuruluşuna ön ayak olmuş, bir dönem müdire olarak çalışmış ve Batılı anlamda sanat eğitimi vermiştir. Meşrutiyet Dönemi’nde ortaya çıkan, özgürlük isteyen güçlü kadın hareketinin sözcüsü olmuştur. Yeğeni Hale Asaf Cumhuriyet Dönemi’nde Batılılaşma hedefi ile Avrupa’ya yollanan sanatçı kuşağı arasında yer almıştır. Paris ve Roma’da sanat çevresi ile erkenden tanışmış, Müstakil Ressamlar ve Heykeltraşlar Topluluğu’nun (1929) kurucularından olmuştur. Cumhuriyet Türkiyesi’nde Mihri ve Hale kendini ressam olarak tanımlayan öncü kadınlardır. Bu çalışmanın amacı; Hale ve Mihri’nin sanatçı kimliklerini oluşturdukları çevreyi, dönemin özelliklerini, sanatçı olarak başlattıkları mücadeleyi ele almaktır. Türkiye sanat tarihindeki yerlerine feminist eleştirel bir açıdan bakmayı denemektir. Cumhuriyet Dönemi sanatçıları olan Mihri ve Hale’yi incelemek için literatür araştırması yapılmış, haklarında yazılmış araştırma, tez ve makaleler incelenmiştir.
Prácticas postfotográficas en los medios sociales. Un estudio transnacional sobre el uso de las historias de Instagram
Authors: Caro-Castaño Lucía
Published: October 2023

El auge de los medios efímeros apunta hacia la aparición de prácticas donde la fotografía y el vídeo asumen nuevas funciones sociales. Este estudio analiza las prácticas y motivaciones de uso que hacen de las historias de Instagram jóvenes españoles y colombianos. La metodología emplea el análisis crítico del discurso a partir de un trabajo de campo basado en el relato de los participantes. Este relato fue recabado a través de grupos focales y de un corpus de sus propias historias (N=1.110). Los resultados muestran prácticas postfotográficas incentivadas por el diseño de la plataforma y el imaginario algorítmico compartido por los participantes. Entre ellas destaca el uso de las historias para a) alimentar la sensación de copresencia y comunidad fática con sus seguidores; b) trasladar autenticidad y sensación de acceso a su vida cotidiana, al yo privado, recuperando el discurso clásico de la fotografía y el vídeo como testigos fidedignos de la realidad; y c) mejorar su performance individual de acuerdo con las métricas sociales de Instagram. El estudio da cuenta de la capacidad de estas plataformas tecnocomerciales para orientar el comportamiento social de sus usuarios y de las transformaciones culturales que esto implica.
Clearing-enhanced 3D (Ce3D) clearing method, immunohistochemistry and quantitation of rat gastric enteric ganglia v1
Authors: Hunne Billie , Furness John , Stebbing Martin , Fothergill Linda
Published: October 2023

The enteric nervous system is an important regulator of gastrointestinal, digestive and metabolic function. Here we describe protocols for clearing rat gastric tissue with the Clearing-enhanced 3D microscopy (Ce3D) method to increase optical clarity, to allow the use of thick tissue preparations for quantitation of the number and size of myenteric and submucosal ganglia in the rat fundus, corpus and antrum
The role of mycoplasmas as an infectious agent in carcinogenesis
Authors: Galyamina M. A. , Pobeguts O. V. , Gorbachev A. Yu.
Published: October 2023

The review presents data on studies of the role of mycoplasmas as infectious agents in carcinogenesis, as well as their participation in cancer drug therapy and the impact on the outcome of treatment. Mycoplasmas are of particular interest because they have unique abilities to readily attach to and enter eukaryotic cells, modulate their functional state, and induce chronic inflammation while evading the host’s immune system. The review will highlight the data confirming the increased colonization of tumor tissue by mycoplasmas compared to healthy ones, describe the molecular mechanisms by which mycoplasmas activate the expression of oncogenes and growth factors, inactivate tumor suppressors, promote NF-κB-dependent migration of cancer cells and modulate apoptosis, which results in abnormal growth and transformation of host cells. The review also presents data on the effectiveness of anticancer drugs in mycoplasmal infections.
Current approaches to systemic treatment of BRCA-associated triple-negative breast cancer
Authors: Enaldieva D. A. , Krivorotko P. V. , Imyanitov E. N. , Zhiltsova E. K. , Donskikh R. V. , Shaikhelislamova L. F. , Gigolaeva L. P. , Semiglazov V. F.
Published: October 2023

BRCA-associated triple-negative breast cancer (TNBC) is characterized by high sensitivity to DNA-damaging cytotoxic drugs. The use of well-known BRCA1/2-specific antitumor agents – platinum derivatives and PARP inhibitors – has been discussed for a long time in the context of the treatment of metastatic BRCA-associated TNBC. Neoadjuvant regimens based on the use of anthracyclines and taxanes are the standard of drug therapy for primary BRCA-associated breast cancer. At present, there are few data regarding the addition of platinum drugs to anthracycline-taxane neoadjuvant chemotherapy in the treatment of primary BRCA-associated TNBC. This review details the various treatment options for both primary and metastatic BRCA-associated TNBC. It has been shown that the development of new strategies for the neoadjuvant chemotherapy of patients with primary BRCA-associated TNBC is an urgent clinical need to reduce the risks of recurrence and progression.
Abnormal uterine bleeding (clinical lecture)
Authors: Sosnova Elena A. , Ageev Mikhail B. , Svidinskaya Evgeniya A.
Published: October 2023

Abnormal uterine bleeding (AUB) not related to pregnancy has been one of the leading reasons for visiting a gynecologist for many years. The incidence of AUB is approximately 30% among patients of reproductive age and can increase to 70% during the perimenopausal period. Recurrent AUB leads to the development of iron deficiency anemia, significantly reducing the quality of life, and also resulting in additional costs for hygiene products.
This clinical lecture provides a modern classification of AUB. It focuses on the main mechanisms of development of this pathology in adolescence and reproductive age. The causes of AUB are analyzed, and the classification, symptomatology, and clinical presentation of the studied conditions are presented. The lecture covers international criteria for pathologic uterine bleeding, clinical criteria for assessing bleeding severity according to MansfieldVodeJorgensen scale and estimation of blood loss volume according to Algover index. Detailed consideration is given to the issues of differential diagnosis, general principles of therapy, and indications for traditional, hormonal, and surgical hemostasis. The lecture also outlines the algorithm of diagnostic search for patients in the adolescent, reproductive, postmenopausal age groups, as well as for patients on the background of menopausal hormonal therapy.
Effects of COVID-19 on the body of a pregnant woman with preeclampsia: Birth outcomes (literature review)
Authors: Shchegolikhina Larisa V. , Zainetdinova Adelya N. , Amirova Liliya D.
Published: October 2023

In contemporary obstetrics, increasing attention is being paid to identifying problems diagnosed during pregnancy that are believed to increase the risk of complications during pregnancy and labor. The effect of COVID-19 on the body of the pregnant woman as well as its association with preeclampsia and their combined effect on the organisms of the mother and fetus, as well as the specifics of the effect on the course and outcome of labor, have emerged as significant and well-studied problems in obstetric.
The aim of this study was to analyze the effects of COVID-19 on pregnant women with preeclampsia, including possible maternal and/or fetal complications, birth outcomes, delivery methods, and the influence of existing extragenital pathology.
The authors conducted a detailed analytical review of the scientific literature published from 2020 to 2022 on the study topic, gathering information from various sources, such as conference proceedings, technical reports, journal articles, abstracts, and papers available through databases, such as Medline, Google Scholar, and PubMed.
Based on current scientific evidence, pregnant women with COVID-19 have a high incidence of preeclampsia, preterm labor, and operative delivery. The existence of intrauterine vertical transmission has not been reliably proven. The frequency of complications in newborns corresponds with general population indicators.
Progression of antenatal preeclampsia in the postpartum period (clinical cases)
Authors: Ignatko Irina V. , Bogomazova Irina M. , Fedyunina Irina A. , Timokhina Elena V. , Belousova Vera S. , Kuz’mina Tat’yana E. , Kardanova Madina A. , Muravina Elena L. , Samoilova Yulia A. , Rasskazova Tat’yana V. , Gutsu Vladimir
Published: October 2023

Background. Preeclampsia is recognized as one of the leading causes of maternal morbidity and mortality. In the majority of observations in the postpartum period, symptoms of preeclampsia appear in patients with antenatal hypertensive complications. These symptoms appear within the first 710 days after delivery and are accompanied by high blood pressure (BP) and neurologic symptoms, commonly presenting as headaches. According to the literature, common risk factors for the progression of preeclampsia in the postpartum period include maternal age over 3540 years, obesity, cesarean section delivery, and non-Hispanic black race. Patients with progression of antenatal preeclampsia in the postpartum period often require readmission after discharge from the hospital.
Description of clinical cases. The first clinical observation involves a 25-year-old female patient was transferred to the cardiology department of the hospital on the fourth day after her first spontaneous labor due to a significant increase in BP combined with complaints of intense headache, nausea, and itching of the palms. Progression of antenatal preeclampsia complicated by the cholestasis was detected. The implementation of a complex treatment led to the normalization of clinical and laboratory parameters. In the second clinical observation, a 31-year-old first-pregnant patient at the gestational age of 27 weeks underwent emergency cesarean section due to the development of eclampsia. The patient developed thrombocytopenia and massive proteinuria a day after delivery for the first time, along with high BP, which was not present during pregnancy. The application of a personalized approach to treatment helped stabilize the maternity patients condition.
Conclusion. The presented clinical observations demonstrate the progression of antenatal preeclampsia in the postpartum period. In both cases, disturbances of laboratory parameters, high arterial hypertension, resistant to previously conducted antihypertensive therapy, were noted. Given that preeclampsia is a risk factor for severe complications, patients should not be discharged after delivery until clinical and laboratory parameters have completely normalized.
Healthcare-associated infections in the constituents of Ural and Siberian Federal Districts: results of monitoring their identification and registration in 2022 and in long-term dynamics
Authors: Malkova Светлана S. , Egorov Ivan A. , Stagilskaya Yulia S. , Zhuikov Nikolai N.
Published: October 2023

Rationale. Monitoring of HAI (health care-associated infections) detection and registration of is one of the key components in the information subsystem of epidemiological surveillance for these infections. Despite a well-established HAI recording system in the Russian Federation as a whole, the constituents of the Ural and Siberian Federal Districts have different approaches to detection of these infections, which is confirmed by the final rating scores of their detection and registration.
Objective. We studied HAI detection and registration in the constituents of the Ural and Siberian Federal Districts for ranking and rating their systems of epidemiological HAI surveillance.
Materials and methods: The data of federal statistical monitoring forms No. 2 "Information on infectious and parasitic diseases" and No. 23-17 "Information on outbreaks of infectious diseases as well as from additional enquiry materials "Information on medical manipulations and cohorts treated" in 20182022 submitted by the Rospotrebnadzor offices of the respective Russian Federation constituents compared with the long-term and Russias nationwide averages. The quality of HAI registration in the healthcare institutions of the Ural and Siberian Federal Districts was rated using grouping by intensive incidence indicators, and the most significant groups of infections and risk cohorts were selected for analysis.
Results: The results of the HAI detection and registration by the most significant groups of infections and risk cohorts among the patients and healthcare workers were analyzed. The data on the group and outbreak HAI morbidity in the healthcare institutions are presented. The quality of HAI detection and registration in the constituents of the Ural and Siberian Federal Districts was rated, and the subjects were ranked with regard to the activity of their epidemiological surveillance system.
Conclusion: Active detection and registration of HAI cases over several years is typical for the healthcare institutions of Sverdlovsk and Chelyabinsk Oblasts as well as Yamalo-Nenets Autonomous District. Consistently low rating scores of the studied parameters are typical for the healthcare institutions of the Republics of Tyva, Altai and Krasnoyarsk Krai.
Why does a warm-blooded organism rapidly regulates body temperature in the thermoneutral zone
Authors: Luchakov Yury I. , Shabanov Petr D.
Published: October 2023

In work, the analysis of thermal homeostasis in the human body and homoiotherm animals. It is shown that the temperature in the internal tissues of the body (the nucleus of the body) is high and relatively consistent because it is maintained via heat transfer through the blood flow. The presence in peripheral tissues (the body shell) is mainly due to conductive heat transfer (due to temperature gradients at various points of the tissues). Thermal homeostasis occurs when the temperature of the medium fluctuates within the thermoneutral zone in the internal tissues of the body, primarily due to changes in the size of the nucleus and shell rather than changes in heat output to the external environment or heat production. Owing to this mechanism of heat transfer in the tissues, a rapid thermal homeostasis of the internal tissues of the body is carried out when the temperature of the medium changes within the thermoneutral zone.
Physical-chemical repurposing of drugs. History of its formation in Russia
Authors: Urakov Aleksandr L. , Shabanov Petr D.
Published: October 2023

It is reported that the traditional scheme of finding and developing a new drug and conducting the whole complex of preclinical studies requires several thousand chemical compounds, hundreds of millions of US dollars and more than 12 years of work. It is shown that physicochemical pharmacology was born in Russia at the end of the 20th century, which in our days has been transformed into physicochemical repurposing of known medicines. The first successfully repurposed known drug was a solution of 4% potassium chloride, which had previously traditionally belonged to the group of macro- and microelements, used by intravenous injections to regulate acid-base balance and rhythmic activity of the heart. In 1983, it was stated that this medicinal solution, when heated to 3942C and applied topically by irrigation of the bleeding surface, could be classified as a vasoconstrictor and hemostatic drug. Hyperthermia was used as a physico-chemical reprofiling factor, which, according to the Arrhenius law, accelerated and intensified, on the one hand, the spastic action of K+ cations on the gaping blood vessels (formation of hyperkalium contracture in the smooth muscles of the vascular wall) and, on the other hand, the blood clotting process in the wound. In subsequent years, the promise of physicochemical repurposing of known drugs was shown on the example of water, hydrogen peroxide, sodium chloride and sodium bicarbonate by purposefully changing their temperature, acid, osmotic activity, as well as the amount and quality of gas content (passing). A chronology of the physicochemical repurposing of known drug solutions and tablets is described and the essence of such new groups of drugs as bleachers of bruises and pyolytics is given. It is shown that both groups of drugs were discovered in Russia and are intended for local use to bleach bruises (blood stains) and dissolve thick mucus, sputum, pus, blood clots, meconium and other dense biological tissues containing the enzyme catalase. It is pointed out that the advantage and at the same time the limitation of the known drugs repurposed according to this scheme is their local application, since their new pharmacological activity is caused mainly by the physical and chemical principle of action, which is manifested by local interaction with the selected area of the patients organism.
Prognostic Significance of Carotid and Lower Extremity Artery Stenosis in Patients With High and Very High Cardiovascular Risk
Authors: Genkel V. V. , Kuznetsova A. S. , Lebedev E. V. , Salashenko A. O. , Shaposhnik I. I.
Published: October 2023

Aim      To study prognostic significance of the degree of stenosis of carotid and lower-extremity arteries (LEA) in patients at high and very high risk of cardiovascular complications (CVC).

Material and methods  The study included men and women aged 40–67 years at high and very high risk of CVC. Duplex ultrasound scanning of carotid arteries and LEA was performed for all patients. Laboratory tests included measurements of glucose, glycated hemoglobin, total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, uric acid, creatinine with estimation of glomerular filtration rate (GFR) using the CKD-EPI Creatinine Equation formula, and high-sensitivity C-reactive protein (hsCRP). Composite endpoint was death from CVC, nonfatal myocardial infarction, nonfatal stroke, and coronary revascularization.

Results The study included 214 patients from groups of high and very high risk of CVC. Median age of patients was 59.0 [53.2; 64.0] years. A very high risk was identified in 141 (65.8 %) patients and a high risk of CVC in 73 (34.1 %). Atherosclerotic plaques in at least one vascular bed were found in 191 (89.3 %) patients. Duration of the follow-up period was 32.0 [13.7; 49.1] months. Outcomes comprising the composite endpoint were observed in 36 (16.8 %) patients. Presence of carotid stenosis ≥35 % was not statistically significantly associated with the occurrence of outcomes comprising the composite endpoint (relative risk, RR: 1.22; 95 % confidence interval, CI: 0.56–2.66; p=0.607). In contrast, the presence of LEA stenosis ≥35 % was associated with a 2.51 times increased RR of CVC (95 % CI: 1.02–6.23; p=0.044).

Conclusion      In patients from the groups of high risk and very high risk of CVC, the presence of LEA stenosis ≥35 % predicted the development of severe CVC with a 69.4% sensitivity and a 61.8% specificity. The presence of LEA stenosis ≥35 %, but not of carotid arteries, was an independent predictor of severe CVC (RR, 2.51; 95 % CI: 1.02–6.23; p=0.044) after adjustments for sex, age, presence of arterial hypertension, diabetes mellitus, ischemic heart disease, obesity, smoking, LDL-C, GFR, and drug therapy.
The Frozen Elephant Trunk Procedure Using New Russian Hybrid Prosthesis “Soft Elephant Trunk”: the Early Experience
Authors: Charchyan E. R. , Breshenkov D. G. , Belov Yu. V.
Published: October 2023

Aim      To present the first experience of performing the Frozen Elephant Trunk (FET) surgery in patients with thoracic aorta disease using a new Russian hybrid stent graft “Soft Elephant Trunk”.

Material and methods  Between 2014 and 2021, 170 patients with thoracic aortic disease underwent complete aortic arch replacement using the FET technique. In 70 of these cases (since June 2019), a hybrid graft “Soft Elephant Trunk” was used. A specific feature of this graft is the conical reduction of the radial force of nitinol crowns and the soft distal end without radial force. The study endpoints were early postoperative results, as well as the absence of reoperations on the aorta, absence of stent-graft-associated complications, including distal stent-graft-induced fenestration, and survival at a mid-term follow-up of up to 2.5 years.

Results Interventions were performed in patients with A type aortic dissection (n=51; 72.9 %), type B aortic dissection (n=13; 18.6 %), and thoracoabdominal aortic aneurysm (TAAA) (n=6; 8.5 %). In 14 (20 %) of these cases, interventions were performed after a primary intervention on the proximal aorta. Acute aortic dissection was diagnosed in 17 (24.3 %) cases. Aortic root replacement was performed in 21 (30 %) cases, David procedure in 5 (7.2 %) cases, Bentall-DeBono procedure in 11 (15.7 %) cases, and supracoronary graft placement in 33 (47.1 %) cases. There were no cases of paraplegia or paraparesis. Respiratory insufficiency was observed in 8 (11.4%) cases. In one (1.4%) case, acute renal failure developed, which required renal replacement therapy. In-hospital mortality was 4.3 % (3 patients died). Mean follow-up duration was 9 [4.25; 16] months. Three-year survival was 94 % (95 % confidence interval, CI: 88–99.9) and absence of reoperation was 96.6 % (95 % CI: 90.1–100). There were no cases of distal stent-graft-induced fenestration in this group.

Conclusion      The new hybrid graft, due to its specific structure, provides prevention of distal stent-graft-induced fenestration and, thereby, a stable long-term result. Using this stent-graft is effective in patients with thoracic aorta pathology undergoing the FET surgery. However, further studies are needed to determine potential advantages and disadvantages of this new hybrid graft, to obtain long-term results and accumulate experience.
The Protective Effect of Polymorphisms rs2681472 and rs17249754 of the ATP2B1 Gene Against Coronary Artery Disease and Hypertension is Abolished by Tobacco Smoking
Authors: Kononov S. I. , Azarova Yu. E. , Klyosova E. Yu. , Bykanova M. A. , Solodilova M. A. , Polonikov A. V.
Published: October 2023

Aim    To study the relationship of single nucleotide polymorphisms rs2681472 and rs17249754 in the ATP2B1 gene with risk of ischemic heart disease (IHD) and arterial hypertension (AH) among residents of Central Russia and to evaluate the trigger role of smoking as a risk factor for development of IHD and AH in carriers of ATP2B1 gene polymorphic variants.Material and methods    The study included DNA samples from 1960 residents of Central Russia of Slavic origin. Among them, there were 1261 patients with cardiovascular diseases and 699 healthy persons. The vast majority of patients had both IHD and AH. Genotyping was performed using the iPLEX technique on a MassARRAY-4 genomic mass-spectrometer. The relationship of ATP2B1 alleles, genotypes, and haplotypes with the risk of diseases was calculated by logistic regression analysis with adjustments for sex and age.Results    Carriage of AG and GG (rs2681472) genotypes and GA (rs17249754) genotype was associated with a reduced risk of both IHD (p=0.0057 and p=0.022 for rs2681472 and rs17249754, respectively) and AH (p=0.016 and p=0.036, respectively). Rare rs2681472G-rs17249754G and rs2681472A-rs17249754A haplotypes were associated with a reduced risk of IHD (odds ratio, OR, 0.22; 95 % CI: 0.11–0.46, p=0.0001) and AH (OR, 0.22; 95 % CI: 0.10–0.47, p=0.0001). Analysis of the groups stratified by the smoking status showed that in smokers, the studied polymorphic variants did not have a protective action with respect of either IHD or AH. However, in non-smokers, the genotypes AG and GG rs2681472 (OR, 0.62; 95 % CI: 0.47–0.80, p=0.0004) and GA rs17249754 (OR, 0.61; 95 % CI: 0.47–0.81, p=0.0004) were associated with a reduced risk of IHD and AH (OR, 0.63; 95 % CI: 0.48–0.83, p=0.0004 for rs2681472; OR, 0.63; 95 % CI: 0.48–0.83, p=0.001 for rs17249754), as well as the carriage of the minor alleles rs2681472‑G and rs17249754‑A.Conclusion    It was shown for the first time that the polymorphic variants rs17249754 and rs2681472 of the ATP2B1 gene are associated with a reduced risk for IHD and AH only in non-smokers.
Variability of Measurement and Feasibility of Assessing Changes in Brachiocepahlic Atherosclerotic Plaque After Acute Coronary Syndrome
Authors: Bershtein L. L. , Boldueva S. A. , Kochanov I. N. , Lunina M. D. , Naiden T. V. , Evdokimov D. S. , Tandelov B. M. , Podmetin P. S. , Zbyshevskaya E. V. , Gumerova V. E. , Savinova E. B. , Piltakyan V. H. , Sayganov S. A.
Published: October 2023

Aim     Analysis of inter- and intra-study variability of changes in the atherosclerotic plaque (ASP) total height and total area, the main quantitative indexes that were planned to be used in the present study for assessment of the atherosclerotic load of carotid arteries.

Material and methods The incidence of recurrent cardiovascular complications (CVC) within 1 year after acute coronary syndrome (ACS) ranges from 7-9 % (in studies) to 34 % (in clinical practice). This indicates insufficient efficacy of traditional approaches to secondary prevention of coronary heart disease. We proposed a study to test a hypothesis that the dynamics of ASP parameters in carotid and subclavian regions can serve as an alternative criterion for the adequacy of secondary prevention after ACS. The analysis was performed on subgroups of main study participants. These patients had ACS of any type documented by coronary angiography with an ASP confirmed by ultrasound of the brachiocephalic arteries (BCA) during the index hospitalization. BCA ultrasound was performed to analyze the inter- and intra-study variability of BCA atherosclerotic load, the ASP total height (Hsum) and total area (ASPTA), in 20 and 24 patients of the main study, respectively. Results of the repeated ultrasound were evaluated in 30 patients of the main study after 6 months of follow-up.

ResultsThe inter-study variability of each index was significantly higher than the intra-study variability which was consistent with results of previous studies. The intra-study variability of Hsum was 0.10 (95 % confidence interval, CI – 0.23–0.44) mm and ASPTA, 1.05 (95 % CI, – 0.54–2.63) mm2. The variability values were considerably smaller than the changes for 6 months: Hsum, 0.92 (95 % CI, – 0.64–2.49) mm and ASPTA, 3.67 (95 % CI, 0.42–6.91) mm2, although the difference did not reach statistical significance. The above results were obtained at an early stage of the study during the adaptation of specialists to the protocol.

Conclusion      The study results suggest a possibility of a fairly reliable assessment of the dynamics of quantitative indexes of carotid ultrasound 6 months after ACS.
Twitter’da Korku Söylemi Kullanımı: Siyasi Liderlere Dair Karşılaştırmalı Bir Analiz
Authors: KAHRAMAN İbrahim
Published: October 2023

İnsanları “ben” olmaktan çıkararak “biz” olmaya iten korku, toplumsal yapının oluşmasında ve bu yapıdaki yöneten-yönetilen ilişkilerinde rol oynayan temel ve belki de en güçlü duygudur. Bu duygu yönetenler ve yönetmek isteyenler tarafından halkın desteğini ve rızasını alarak iktidar alanlarını kazanmak, bu alanları korumak ve genişletmek amacıyla kullanılmaktadır. Sağlık, ekonomi, terörizm, savaş, demokrasi ve benzeri konulardaki korku kaynakları özellikle seçim dönemlerinde insanların sevk ve idarelerini sağlamak amacıyla daha yoğun şekilde kullanılmaktadır. Çok kısa sürede geniş kitlelere erişilebilmesini sağlayan sosyal medya platformları ise belirli amaçlar doğrultusunda oluşturulan bu korkuların yayılımına hizmet etmektedir. Özellikle toplumsal hareketlerin ve siyasi konuların mecrası haline gelen Twitter, aynı zamanda söz konusu korkuların üretildiği, dağıtıldığı ve tüketildiği bir mecradır. Bu bağlamda çalışmada, korkunun siyasi çıkarlar doğrultusunda kullanılmasına açıklık getirmek amacıyla Cumhur ve Millet İttifakı’nda yer alan siyasi parti liderlerinin 2023 Türkiye Cumhurbaşkanlığı Seçimine hazırlık döneminde paylaştıkları tweetler içerik analizi tekniği ile incelenmiştir. İki haftalık zaman diliminde paylaşılan tweetlerle sınırlı olan bu çalışma, korkunun Twitter ve siyasetle bağdaştırılarak incelendiği nadir çalışmalardan bir tanesi olması nedeniyle önem taşımaktadır. Analizler sonucunda, makul oranda kullanılması halinde korkunun daha geniş kitlelere erişebilmeyi sağladığı, ancak korku kültürünün siyasi başarıda tek başına belirleyici bir role sahip olmadığı görülmüştür.
Bağ(ım)lı Bireyden Yorgun Bireye: Dijital İletişim Çağında Sosyal Ağ Yorgunluğu
Authors: ZAMUR TUNCER Rabia , TANIR LEVENDELİ Şafak
Published: October 2023

Mobil bilgi teknolojisinin hızlı gelişimi ve akıllı cihazların günden güne gelişmesiyle birlikte özellikle akıllı telefonlar ve sosyal medya uygulamaları iletişim süreçlerini ve daha birçok dinamiği değişime uğratmıştır. Kişilerarası iletişim ve etkileşimin büyük bir bölümünün internet ve mobil cihazlar aracılığıyla gerçekleştirilmesi ve yaygın sosyal medya kullanımı, kullanıcıların paylaşılan içerikleri anında takip etme, sürekli etkileşim halinde olma gibi kaygılar taşıyarak bu platformlara olan bağ(ım)lılığını arttırmış ve bu artış birtakım endişeleri de beraberinde getirmiştir. Bu bağlamda, günlük hayattaki tüm insani süreçlerin dijitalize olmasıyla, sosyal ağ platformlarının “aşırı” kullanımı çeşitli yorgunluklara yol açmıştır. Bu çalışmanın odağında bulunan, dijital çağın yeni salgını olarak nitelendirilen sosyal ağ yorgunluğu da bunlardan biridir. Bu makalede, dünyanın karşılıklı bağımlı ve bağlı olduğu bir dönemin zorunlu bir sonucu olarak artan sosyal ağ yorgunluğunu temel kavramlar ve güncel bulgular ışığında irdelemek amaçlanmaktadır. Bu amaçla öncelikle, sosyal ağ yorgunluğu üzerinde durulmuş ve ilgili kavramlar tanımlanmıştır. Ardından teknostres, gelişmeleri kaçırma korkusu (FOMO), infobezite gibi bağlı çağın sendromlarının sosyal ağ yorgunluğu ile ilişkisi üzerinde durulmuştur. Ve son olarak, sosyal ağ yorgunluğu bağlamında geliştirilen çeşitli öneriler ile çalışma tamamlanmıştır. Sonuç olarak bu çalışmada, her an ve her yerde bağ(ım)lı olmanın bir sonucu olarak sosyal ağ yorgunluğu eğiliminde bir artış olduğu, sosyal medya platformlarının aşırı kullanımının yarattığı sosyal medya yorgunluğunun, literatürdeki ilgili kavramlarla nasıl ilişkilendiği, hangi öncüller ve sonuçlar üzerinden ele alındığı güncel araştırma bulguları doğrultusunda ele alınmıştır. Aynı zamanda bu yorgunluğun kullanıcılarda yarattığı hasarın, son derece önemli psikolojik ve toplumsal sorunlara, kişilerarası iletişim sürecinin olumsuz etkilenmesine neden olduğu ortaya konmuştur.
Prevention and management of Anaemia in Pregnancy in India: Challenges and Opportunities
Authors: Ramachandran Prema , Kalaivani K.
Published: October 2023

Seven decades ago, over 80% of Indian pregnant women were anaemic. About 3/4th of anaemia was due to nutritional deficiencies of: iron (most common), folic acid (second) and vitamin B12 (not as common). Anaemia in pregnancy was associated with higher maternal morbidity and mortality, low birth weight and high perinatal mortality. Detection and appropriate management of anaemia, including parenteral iron therapy and intensive care for severe anaemia were important components of antenatal care in India, but only about 10% of women had access to antenatal care. In 1970s the national programme for anaemia in pregnancy focussed on identifying all pregnant women and providing them iron and folic acid (IFA) supplementation. The coverage and compliance with supplementation were low. In 1990 when the primary health care infrastructure was established, the anaemia control programme embarked on testing and providing appropriate treatment to anaemic women. The tertiary care centres operationalised this “test and treat” strategy. In primary and secondary care settings, accurate test for diagnosis of anaemia was not available. In the absence of accurate Hb estimation at all levels of care, it was not possible to provide appropriate treatment based on Hb levels. So, all pregnant women continued to receive one tablet of IFA throughout pregnancy. Over the next two decades, coverage under antenatal care and IFA supplementation improved but compliance with supplementation was low because about a third of pregnant women had gastrointestinal side effects with IFA. Despite these problems, between 2002 and 2015, there had been a decline in the prevalence of severe and moderate anaemia. To accelerate the decline in anaemia in pregnancy the country is focusing on the ‘test and treat’ strategy in pregnant women using an accurate method for Hb estimation and providing appropriate treatment. Nutrition education to improve iron intake prior to and during pregnancy, is focussing on dietary diversification and use of iron fortified salt or cereals. Progress will be monitored through national surveys and locale specific appropriate mid-course modifications in the programme will be made.
valor ecoeducativo en la poesía de Mariluz Escribano
Authors: Quiles Cabrera María del Carmen , Llamas Martínez Isabel
Published: October 2023

En el presente artículo se establece la conexión entre la educación ambiental y la educación literaria aplicada al aula para fomentar la educación en valores tal y como promulga la LOMLOE. Para ello se utiliza la obra de Mariluz Escribano (1935-2019), una de las autoras principales de la poesía española del siglo XX, incardinada en la Generación del 50 pero incorporada al canon recientemente. La aportación de este trabajo se concentra en el análisis ecocrítico de la poética de Escribano asociada a la reivindicación del patrimonio natural y su necesaria protección para legarlo a las futuras generaciones. Para ello se realiza un recorrido a través de sus poemarios y obras memorialísticas que nos permiten aportar una serie de propuestas significativas para su aplicación en el aula vinculadas a los Objetivos de Desarrollo Sostenible (ODS) que vienen a revelar el rotundo compromiso ético y estético de la escritora granadina con la sostenibilidad y la concienciación medioambiental.
AURA E LENI RIEFENSTAHL: UMA ABORDAGEM TEÓRICA DO CINEMA DOCUMENTAL DE PROPAGANDA NAZISTA
Authors: Quinta Junior Elbio Roberto
Published: October 2023

Aura e Reprodutibilidade Técnica. Tradição e Modernidade. Dois conceitos diametralmente opostos. O Cinema de Propaganda Nazista, sendo Leni Riefenstahl um de seus maiores expoentes, produziu a união destes dois conceitos. Através do conceito de Aura, em Walter Benjamin, e da Análise Fílmica de “O Triunfo da Vontade” (1935) e “Vitória da Fé” (1933), este artigo tem como objetivo analisar um conceito de cinema, no nazismo, que visa à dominação das massas.
SANATÓRIO ESPÍRITA DE ANÁPOLIS: UMA HISTÓRIA CONSTRUIDA ENTRE HISTÓRIAS
Authors: Silveira Marcos Delson da
Published: October 2023

Este artigo inicia-se com uma exposição sucinta relacionada à história do Espiritismo Kardecista destacando seu modus operandi de divulgação no Brasil e, em específico, no Estado de Goiás para construir a percepção sobre o campo religioso que está inserido o Sanatório Espírita de Anápolis. Logo em seguida, expõem, de forma propedêutica, alguns pontos do desenvolvimento econômico em Anápolis, desde sua emancipação política em 1907 até o ano de 1950, para extrair desse exposto o contraste social da desigualdade no expressivo número de mendigos emergentes no Município, neste período. Assim, no último tópico, destacamos os principais pontos da história institucional dos 70 anos do Sanatório Espírita de Anápolis que corresponde o período entre 1950 e 2020.
Comparative evaluation of the effectiveness of various solvents on dissolving efficacy of gutta percha- An in vitro- study
Authors: Bukhari Syed Manzoor Ul Haq , Rashid Sheeeban , Bhat Rahil
Published: October 2023

This study's objective was to compare how well xylene, chloroform, turpentine oil, halothane, and orange oil dissolved materials at three different immersion time intervals.

For the investigation. An ISO no. 40 cone and gutta-percha cones with a 0.06 taper were gathered. In each of the tested solvents, five batches of samples were made and submerged for 6, 12, and 18 minutes. To ascertain the process of gutta-percha dissolution in the solvents, the weight before immersion and the weight after immersion in the solvents were measured on a digital analytical scale. Analysis of Variance (ANOVA) and multiple comparisons with Scheffe's test (p 0.05) were used to statistically analyse the data. With xylene, the best solvency capacity was attained. Halothane, orange oil, and chloroform all had comparable dissolving abilities.
Aprendamos todos a leer: Fascículo 25: Toda la familia lee y escribe conmigo
Authors: De Varela Ana Lorena , Martínez Álvarez Silvia
Published: October 2023

Aprendamos Todos a Leer es la iniciativa para la enseñanza de lectura y escritura inicial del BID, donde a través de materiales para el alumno, el maestro y el aula de clase, pretende brindar herramientas para apoyar el proceso de alfabetización inicial. El programa se organiza a partir de una cartelera fonológica presentando para cada fonema (sonido de letra) un personaje caracterizado por un animal. En respuesta al COVID-19, se desarrollaron fascículos para apoyar el trabajo en casa. Este fascículo contiene diferentes actividades para conocer el sonido y cuando se escribe con el dígrafo Ll-ll, así como para diferenciar cada uno de los sonidos que forman una palabra. Además, se enseña su combinación con las vocales y las consonantes M-m, P-p, N-n, L-l, S-s, F-f, T-t, B-b, D-d, C-c, QU-qu.