bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from Combination Therapies Targeting ALK-aberrant Neuroblastoma in Preclinical Models
Authors: Tucker Elizabeth R. , Jiménez Irene , Chen Lindi , Bellini Angela , Gorrini Chiara , Calton Elizabeth , Gao Qiong , Che Harvey , Poon Evon , Jamin Yann , Martins Da Costa Barbara , Barker Karen , Shrestha Sumana , Hutchinson J. Ciaran , Dhariwal Simran , Goodman Angharad , Del Nery Elaine , Gestraud Pierre , Bhalshankar Jaydutt , Iddir Yasmine , Saberi-Ansari Elnaz , Saint-Charles Alexandra , Geoerger Birgit , Marques Da Costa Maria Eugénia , Pierre-Eugène Cécile , Janoueix-Lerosey Isabelle , Decaudin Didier , Nemati Fariba , Carcaboso Angel M. , Surdez Didier , Delattre Olivier , George Sally L. , Chesler Louis , Tweddle Deborah A. , Schleiermacher Gudrun
Published: April 2023

AbstractPurpose:
ALK-activating mutations are identified in approximately 10% of newly diagnosed neuroblastomas and ALK amplifications in a further 1%–2% of cases. Lorlatinib, a third-generation anaplastic lymphoma kinase (ALK) inhibitor, will soon be given alongside induction chemotherapy for children with ALK-aberrant neuroblastoma. However, resistance to single-agent treatment has been reported and therapies that improve the response duration are urgently required. We studied the preclinical combination of lorlatinib with chemotherapy, or with the MDM2 inhibitor, idasanutlin, as recent data have suggested that ALK inhibitor resistance can be overcome through activation of the p53-MDM2 pathway.
Methods:
We compared different ALK inhibitors in preclinical models prior to evaluating lorlatinib in combination with chemotherapy or idasanutlin. We developed a triple chemotherapy (CAV: cyclophosphamide, doxorubicin, and vincristine) in vivo dosing schedule and applied this to both neuroblastoma genetically engineered mouse models (GEMM) and patient-derived xenografts (PDX).
Results:
Lorlatinib in combination with chemotherapy was synergistic in immunocompetent neuroblastoma GEMM. Significant growth inhibition in response to lorlatinib was only observed in the ALK-amplified PDX model with high ALK expression. In this PDX, lorlatinib combined with idasanutlin resulted in complete tumor regression and significantly delayed tumor regrowth.
Conclusions:
In our preclinical neuroblastoma models, high ALK expression was associated with lorlatinib response alone or in combination with either chemotherapy or idasanutlin. The synergy between MDM2 and ALK inhibition warrants further evaluation of this combination as a potential clinical approach for children with neuroblastoma.
Supplementary Data from A Novel Plant Homeodomain Finger 10–Mediated Antiapoptotic Mechanism Involving Repression of Caspase-3 in Gastric Cancer Cells
Authors: Wei Min , Liu Bingya , Su Liping , Li Jianfang , Zhang Jun , Yu Yingyan , Yan Min , Yang Zhongyin , Chen Xuehua , Liu Jiayun , Lv Xin , Nie Hui , Zhang Qing , Zheng Zhong , Yu Beiqin , Ji Jun , Zhang Jianian , Zhu Zhenggang , Gu Qinlong
Published: April 2023

Supplementary Data from A Novel Plant Homeodomain Finger 10–Mediated Antiapoptotic Mechanism Involving Repression of Caspase-3 in Gastric Cancer Cells
Supplementary Fig. S3 from Suppression of cervical carcinoma cell growth by intracytoplasmic codelivery of anti-oncoprotein E6 antibody and small interfering RNA
Authors: Courtête Jérôme , Sibler Annie-Paule , Zeder-Lutz Gabrielle , Dalkara Deniz , Oulad-Abdelghani Mustapha , Zuber Guy , Weiss Etienne
Published: April 2023

Supplementary Fig. S3 from Suppression of cervical carcinoma cell growth by intracytoplasmic codelivery of anti-oncoprotein E6 antibody and small interfering RNA
Biology of Precancers and Opportunities for Cancer Interception: Lesson from Colorectal Cancer Susceptibility Syndromes
Authors: Monahan Kevin J. , Swinyard Ottilie , Latchford Andrew
Published: April 2023

Hereditary gastrointestinal cancer is associated with molecular and neoplastic precursors which have revealed much about sporadic carcinogenesis. Therefore, an appreciation of constitutional and somatic events linked to these syndromes have provided a useful model for the development of risk models and preventative strategies. In this review, we focus of two of the best characterized syndromes, Lynch syndrome (LS) and familial adenomatous polyposis (FAP). Our understanding of the neoplasia-immune interaction in LS has contributed to the development of immune mediated therapies including cancer preventing vaccines and immunotherapy for cancer precursors. Chemoprevention in LS with aspirin and nonsteroidal anti-inflammatory drugs has also translated into clinical cancer, however the efficacy of such agents in FAP remains elusive when cancer is applied as an endpoint in trials rather than the use of ‘indirect’ endpoints such as polyp burden, and requires further elucidation of biological mechanisms in FAP. Finally, we review controversies in gastrointestinal surveillance for LS and FAP, including limitations and opportunities of upper and lower gastrointestinal endoscopy in the prevention and early detection of cancer.
The Origin of Social Policy for Women Workers: The Emergence of Paid Maternity Leave in Western Countries
Authors: Son Keonhi
Published: April 2023

Comparative welfare research commonly assumes that women’s political demands were not a crucial factor in the early development of welfare legislation, given their limited access to political resources. This article argues that women contributed to enhancing their right to maternity protection once paid maternity leave was adopted. The early development of paid maternity leave was not only an outcome but also a cause of women’s influence in policymaking. Although paid maternity leave was invented by male policymakers in pioneer welfare states, the adoption of paid maternity leave generated political opportunities for women to push for further expansions. Utilizing an original historical dataset of paid maternity leave, I examine the adoption and extension of paid maternity leave in 20 Western countries from 1883 until 1975. I find that women’s political participation shaped the generosity of paid maternity leave but not the timing of its adoption.
The Authentic Self Is the Self-Enhancing Self: A Self-Enhancement Framework of Authenticity
Authors: Guenther Corey L. , Zhang Yiyue , Sedikides Constantine
Published: April 2023

Authenticity refers to behaving in a manner that aligns with one’s true self. The true self, though, is positive. From a self-enhancement standpoint, people exaggerate their strengths and overlook their shortcomings, forming positively-distorted views of themselves. We propose a self-enhancement framework of authenticity, advocating a reciprocal relation between the two constructs. Trait self-enhancement was associated with higher trait authenticity (Study 1), and day-to-day fluctuations in self-enhancement predicted corresponding variations in state authenticity (Study 2). Furthermore, manipulating self-enhancement elevated state authenticity (Studies 3–4), which was associated with meaning in life (Study 4), and manipulating authenticity augmented self-enhancement, which was associated with meaning in life and thriving (Study 5). The authentic self is largely the self-enhancing self.
Parental stress mediates the effects of parental risk factors on dysfunctional parenting in first-time parents: A dyadic longitudinal study
Authors: Senn Mirjam , Stadelmann Céline , Forster Fabienne , Nussbeck Fridtjof W. , Bodenmann Guy
Published: April 2023

Both parental psychological well-being (e.g., depressive symptoms) and parental relationship functioning (e.g., negative communication) are common parental risk factors for dysfunctional parenting. The spillover process from these parental characteristics to dysfunctional parenting is assumed to be amplified by parental stress, which is particularly common among mothers and fathers of young children. However, few studies have examined dyadic spillover processes from parental risk factors and parental stress on parenting in early childhood. In the current study, we first examined direct actor and partner effects of parents’ depressive symptoms and negative communication at 10 months postpartum on dysfunctional parenting at 48 months postpartum in 168 primiparous mixed-gender couples. Second, we analyzed indirect effects via one’s own and the partner’s parental stress at 36 months postpartum using Actor-Partner Interdependence Mediation Models (APIMeM). We found direct actor effects for mothers’ depressive symptoms and negative communication on their dysfunctional parenting. Additionally, indirect actor effects were found for depressive symptoms and negative communication among mothers and fathers. Specifically, mediating effects of depressive symptoms and negative communication on one’s dysfunctional parenting through one’s parental stress were found. There were no indirect partner effects through parental stress. These findings highlight the important role of parental stress in early childhood as a mediator between both individual and relationship parental risk factors and dysfunctional parenting. These results further underscore the importance of longitudinal dyadic analyses in providing early and tailored interventions for both mothers and fathers of young children.
Metacognitive skills in low-code app development: Work-integrated learning in information systems development
Authors: Matook Sabine , Maggie Wang Yazhu , Koeppel Nuria , Guerin Simon
Published: April 2023

Low-code platforms can provide a learning environment that integrates academic theory with practical experiences, allowing students to experience real-world ISD projects. Such a pedagogy is known as work-integrated learning (WIL). In a low-code WIL course, the focus is on the practical development experiences and the delivery of a business application based on client’s requirements. Yet, the real-world ISD experiences may inhibit metacognition, which is essential for students to succeed in future learning of digital innovations. Without metacognition, students struggle to learn how to learn and be reflective about their learning. This study uses a mixed-method design and draws on Flavell’s (1979) theoretical framework to examine metacognition in the context of low-code WIL. In particular, the study examines the effect of learner-oriented factors and task-oriented factors on metacognition and its impact on learning outcomes, such as knowledge confidence, app delivery, and grade. The quantitative results indicate that metacognition is influenced by motivation, the strategic approach, and autonomy, whereas self-efficacy beliefs have no effect. The learning outcomes are also achieved. Qualitative results (students’ essays and apps) corroborate the quantitative results while also providing additional insights into the learning in low-code WIL showing the impact of the platform and agile ISD practices on metacognition. Overall, this study offers IS educators a better understanding of how low-code platforms can foster learning-to-learn while providing real-world practical experiences.
Mistrust: Community engagement in global health research in coastal Kenya
Authors: Sariola Salla
Published: April 2023

This article explores a case of mistrust in global health research and community engagement. It uses ethnographic material collected in 2014 and 2016 in Kenya, concerning community engagement by a HIV vaccine research group working with men who have sex with men and transgender women. In 2010, the research group was attacked by members of the wider community. Following the attack, the research group set up an engagement program to reduce mistrust and re-build relationships. Analysis focusing on mistrust shows the dynamics underlying the conflict: Norms around gender and sexuality, political support for LGBTIQ+ rights, and resources disparities were all at stake for those embroiled in the conflict, including researchers, study participants, religious leaders, and LGBTIQ+ activists in the region. Rather than a normative good with liberatory potential, community engagement in this paper is discussed as a relational tool with which mistrust was managed, highlighting the fragility of participation.
Immersive virtual reality: An effective strategy for reducing stress in young adults
Authors: McGarry Sarah , Brown Ashleigh , Gardner Miranda , Plowright Caitlan , Skou Renee , Thompson Craig
Published: April 2023

Background:

Psychological stress is ubiquitous in young adults, but traditional relaxation strategies such as mindfulness or meditation are not consistently utilised. Immersive virtual reality (VR) is being increasingly used in mental health contexts with improved clinical outcomes. However, there is limited research exploring the perceived usefulness of VR for individuals without a mental health diagnosis.

Aim:

To identify if an immersive VR experience was effective in reducing stress for young adults and to explore the experience of the participants.

Methods:

Twenty-one young adults aged 18–25 years participated in an immersive VR experience. Heart rate was measured pre- and post-test to objectively establish the efficacy of VR to facilitate relaxation. Participants were invited to participate in a semi-structured interview ( n = 18) to gain a rich understanding of their experience.

Results:

Four themes emerged from analysis of the interviews: I felt relaxed and calm, It was time-efficient and easy to use, It took me to another place and It was different than I thought it would be. Heart rate reduced during the immersive VR experience.

Conclusion:

These findings suggest that immersive VR can reduce psychological stress, and it is perceived by young adults as a useful and time-effective strategy to reduce psychological stress.
What Ails Dalit Movement: Lessons Learnt from Farmer Movement
Authors: Singh Rajeev Kumar , Pushpam Akshat , Kiran
Published: April 2023

The demand for equality and a ‘better’ share is always there for any ‘authoritative allocation of values’ and India is no exception. Farmers and Dalit movements present such demands with an aim to seek transformation in the existing power structure for better in political, social and economic spaces. However, one seems to be more organized and successful despite the existence of a multi-layered class structure, while the other remained fragmented and sporadic. It is, therefore, very pertinent to analyse why a considerable chunk of the citizenry is not able to get their due share and what ails their collective bargaining capacity. The present article is an attempt to draw certain commonalities between the ‘Farmer’ and ‘Dalit’ movements in India and identify the gaps—that the Dalit movement can fill by taking a cue from the farmer movement. Also, it attempts to analyse how with time all the farmers’ organizations collectively mobilized together on the pan-India level on a single platform to bargain for their common interest but why such consciousness is not being developed among Dalits even after 75 years of independence.
The current state of criminology in Chile: between amateurism and professionalisation
Authors: González Guarda Claudio , Salazar-Tobar Felipe
Published: April 2023

This paper explores the criminological scientific community in Chile from 1990 to 2020. We use the sociology of scientific knowledge as a conceptual framework to apply to the Chilean criminology development stage. We analyse the criminological community using social network analysis based on the co-affiliation networks of researchers (N=62) affiliated with research centres, think tanks and universities producing criminological knowledge. We describe the actors involved in the network of researchers and identify the clusters shaping the main areas of the country’s production and dissemination of criminological research. The findings reveal a low density between scholars in the network; the existence of central research topics related to citizen security and criminal law; the presence of clusters (for example, juvenile justice and prison studies, among others), and areas that are emerging in the production of criminological knowledge in Chile (cybercrime, crimmigration). We conclude that criminology in Chile is still in the amateur stage. However, there are signs of growing professionalisation in the discipline.
The role of pragmatics in the definition of evidentiality
Authors: Bergqvist Henrik , Grzech Karolina
Published: April 2023

This paper argues that a definition of evidentiality as a linguistic notion should be based on the pragmatic properties of evidential forms and their distribution in spoken discourse. The prevailing definition of evidentiality as signaling “information source” is based on the idea that evidentials encode a solitary speaker’s perception and cognitive processes, but this definition does not fit well with observations regarding the use and distribution of evidentials. A definition of evidentiality in terms of “information source” has largely disregarded evidentials in-use, which is especially true for typologically oriented studies of evidentiality. Recent descriptions of evidentials and evidential systems have shown that evidentials encode meanings related to ownership of knowledge, rather than information source and it is evident from such descriptions that social and interactional parameters are encoded in evidential forms. The attested semantic and pragmatic complexity of evidential systems constitutes an analytical challenge that the present paper aims to address.
Features of lymphocyte subset composition in neonates born to mothers suffered from COVID-19 at different stages of pregnancy
Authors: Inviyaeva Evgeniya V. , Kosolapova Julia A. , Krechetova Lyubov V. , Vtorushina Valentine V. , Makieva Mziya I. , Zubkov Victor V.
Published: April 2023

The relationship between the incidence of COVID-19 in pregnant women who have had a coronavirus infection at different gestational ages and the health status of paired neonates is of great interest. However, no sufficient convincing data fully reflecting features of subsequent neonatal period, the state of the immune system in this category of children, affecting characteristics of postnatal period have been accumulated. Based on this, it underlies the relevance of the current study aimed at investigating parameters of clinical and immunological state of neonatal health after paired mothers recovered from COVID-19 at different gestational ages. The prospective study included 131 women and 132 children. The main group consisted of women (n = 61) who had COVID-19 during pregnancy and paired newborns (n = 62) at gestational age (GA) of 3741 weeks, the comparison group women without laboratory-confirmed COVID-19 during pregnancy (n = 70) and paired newborns (n = 70) of similar gestational age. While analyzing the anamnesis of the patients, no significant differences in somatic and obstetric-gynecological diseases were found. Analyzing course of pregnancy revealed that low molecular weight heparins were significantly more often applied in the main group. The term and frequency of delivery by caesarean section in pregnant women in the main group did not significant differ from that of the control group. No significant difference in the frequency of causes accounting for the severity of the condition of neonates in paired mothers with COVID-19 at different trimester of gestation was found. Investigating lymphocyte subset composition, neutrophil phagocytic activity, and IgG class antibodies specific to SARS-CoV-2 was carried out. It was found that lymphocyte subset profile in newborns from paired mothers with COVID-19 at different trimesters of gestation differed only in the level of NK cells (CD56+) in children born to mothers recovered from COVID-19 in the first trimester. In this study, in general, no severe perinatal outcomes in newborns from paired mothers with COVID-19 during pregnancy were documented. No cases of moderate or severe maternal COVID-19 were observed. Therefore, further prospective studies are needed to assess an impact of COVID-19 severity on maternal and fetal birth outcomes and clarify optimal management of pregnant women in such cases.
Method of selective isolation of Acinetobacter baylyi from river water
Authors: Sivolodskii Evgeny P. , Kraeva Lyudmila A. , Melnikova Elena V.
Published: April 2023

The aim of the study is to increase the selectivity of isolating Acinetobacter baylyi from river water. For developing a selective culture medium, we used 5 strains of A. baylyi, 4 of which were isolated from the water of the river Neva, 1 from clinical material. A. baylyi strains were identified by a combination of phenotypic features and/or using the mass spectrometric method (MALDI-ToF MS). In preliminary studies we found that the bacteria A. baylyi utilizes no L-phenylalanine as a single source of carbon and nitrogen, as well as the only source of carbon in a medium with mineral nitrogen sources, but utilizes L-phenylalanine as the only source of nitrogen only if it is supplemented with ethanol as the only source of carbon. Based on this A. baylyi property, a selective medium was developed for the isolation of these bacteria from river water. Composition and preparation of liquid selective medium were as follows: 1 liter of distilled water added with L-phenylalanine (CAS 63-91-2) 2.0 (g/l); NaCI 5.0; Na2SO4 2.0; KH2PO4 1.0; K2HPO4 2.5; MgSO4 0.1; dissolved while heating, boiled for 5 minutes, 4 ml of 96-degree ethanol was added to a warm medium, pH 7.20.2 assessed; 40 ml were poured into sterile vials. Dense selective medium: the same ingredients and extra 15.0 g of agar are added to 1 liter of distilled water; with similar preparation technique, the medium is poured into sterile Petri dishes. Method of application of selective nutrient medium for isolation of A. baylyi from river water: water from the river Neva is seeded in a volume of 10 ml into a vial with 40 ml of liquid selective medium, incubated in aerobic conditions at 28С for 48 h, then the enriched material from the flask is placed with a bacteriological loop onto the surface of same dense selective medium in two flasks; incubated in aerobic conditions at 28С for 48 h. 10 isolated colonies are selected for subsequent identification, they are transplanted into sectors of nutrient agar, incubated at 28С 24 h and isolates are identified by a complex of phenotypic characteristic of A. baylyi, and/or by the MALDI-ToF MS method. In this case, 19 isolates from 20 were identified as A. baylyi (95% of isolates). A study using this technique of three more water samples from the river Neva showed the results of the same narrowly selective orientation 9095% of the isolates were bacteria A. baylyi.
Conductas elegidas o forzadas a elegir: normas y valores asumidos por los ejecutivos
Authors: Reynoso Espinoza Deivit Wilfredo , Arbaiza Fermini Lydia
Published: April 2023

Esta investigación describe algunos de los valores y las normas que los ejecutivos de empresas utilizan para elegir sus conductas en los entornos laborales, sociales y familiares. Usando metodología cualitativa, la recolección de datos se realizó con el apoyo de la técnica proyectiva denominada “historia de vida”. La codificación y análisis de la técnica aplicada permitió el reporte de normas y valores que se encuentran en uso por los ejecutivos. En esta investigación participaron cincuenta y tres ejecutivos de empresas de distintos sectores. Los análisis muestran que los ejecutivos siguen y alinean sus conductas a normas y valores que demuestran sus membresías con los grupos. Estos lineamientos tienen efectos positivos y, en otros, negativos para sí mismos, su familia, sus compañeros de trabajo y de sus amigos. Entre los primeros, los ejecutivos buscan demostrar y exigir el uso rentable del tiempo, lograr el desarrollo y crecimiento organizacional y alcanzar posiciones de liderazgo. También se observan marcos de referencia para sus conductas con efectos no positivos o ambiguos. Entre estos se muestra que los ejecutivos presentan como normas y valores el estar dispuestos a sacrificar su tiempo familiar por los objetivos de la empresa, tolerar condiciones de maltrato y maltratar, y mantenerse al margen o involucrarse lo menos posible con las personas con las que trabajan. Lo descrito en el estudio podría permitir proponer que los ejecutivos siguen las normas y valores (NV) que perciben como propias y determinantes para demostrar su membresía. Este carácter de exigencia hace que racionalicen y transfieran al exterior la responsabilidad de las consecuencias a sus conductas.
The relationship between the psychological distress derived from COVID-19 and the loss aversion is modulated by the alexithymia trait
Authors: Molins Francisco , Serrano Miguel Angel
Published: April 2023

Studies on stress and decision-making usually address acute and artificial stressors. However, COVID-19 outbreak set the perfect scenarioto address how decision-making, and specifically loss aversion, could be affected by a real and persistent stressor, able to promote a significantpsychological distress. In parallel, alexithymia has been identified as a potential moderator of the loss aversion expression, since it could impairthe incorporation of emotional information when making a decision, leading to “cold” decisions. Through a within-subjects design (N = 70), ouraim was to study the relationship between the psychological distress caused by the pandemic context and the loss aversion changes, consideringalexithymia as a moderating factor. Our results show a significant increment in both psychological distress and loss aversion, merely one monthafter the confinement’s onset. Moreover, both variables were positively associated only when alexithymia was low, i.e., the alexithymia bufferedthe effect of psychological distress on decision-making: a higher alexithymia implied a lower loss aversion increase.
Voluntariado corporativo: definición y relación con la Responsabilidad Social Empresarial
Authors: Licandro Goldaracena Oscar Daniel
Published: April 2023

el objetivo de este trabajo es la construcción de una definición de voluntariado corporativo útil para analizar cómo este concepto puede vincularse con el de Responsabilidad Social Empresarial. Se recurrió a la investigación bibliográfica mediante la consulta de diversas bases de datos. Se analizó un amplio espectro de interpretaciones teóricas e investigaciones empíricas, lo que sirvió para identificar cada uno de los componentes de la definición propuesta y para fundamentar que esa definición es funcional a las principales formas de definir la Responsabilidad Social Empresarial. La definición combina características específicas del voluntariado corporativo, elementos relacionados a su gestión y una síntesis de los beneficios que esta actividad genera para los actores involucrados. Este trabajo contribuye al desarrollo teóricodel voluntariado corporativo, a la construcción de herramientas útiles para realizar investigaciones empíricas y a la elaboración de estrategias y metodologías de gestión para la implementación de programas de voluntariado corporativo que funcionen efectivamente como herramientasde Responsabilidad Social Empresarial.
Capital Asset Pricing Model (CAPM) applied to the corporate sector of Ecuador
Authors: Reyes-Clavijo Marco Antonio , Pinos-Luzuriaga Luis Gabriel , Orellana-Osorio Iván Felipe , Tonon-Ordóñez Luis Bernardo
Published: April 2023

Las metodologías para el cálculo del riesgo de mercado han sido aplicadas principalmente a economías de países desarrollados. En este trabajo de investigación se propone utilizar el CAPM para determinar el riesgo de mercado y rendimiento mínimo esperado de las empresas del sector corporativo de Ecuador para el periodo 2009-2019. En promedio se analizaron 48 667 empresas, con base en la información obtenida de la Superintendencia de Compañías, Valores y Seguros (SCVS). Los sectores que fueron analizados de acuerdo con la Clasificación Industrial Internacional Uniforme (CIIU). En los cálculos se utilizó un Beta contable, considerando el incipiente desarrollo de la bolsa de valores del país; se realizó una estimación por mínimos cuadrados ordinarios y se propuso un ROE ajustado. Además, se calculó el rendimiento mínimo esperadodel sector por medio del CAPM. Entre los principales hallazgos se destaca que los sectores B, C, G, H, J, M, y N tienen un Beta mayor a 1, es decir,estos sectores son más sensibles ante una variación en el mercado. También es importante mencionar que los sectores P, G, C, E, J y Q tienen undesempeño mejor al esperado. La información proporcionada sirve como apoyo para las organizaciones u otros grupos de interés, considerando elalto nivel de incertidumbre en el mercado.
Orca reproduction in captivity: A review of the science, ethics and welfare concerns
Authors: Dante McGillian
Published: April 2023

Orca whales, also known as killer whales, are highly social and intelligent animals that have captured the public’s fascination for decades. However, the use of orca whales in marine parks and aquariums for human entertainment has sparked controversy about their welfare and ethical considerations. Captive breeding programs have been developed for several marine species, including orca whales, to ensure their survival. However, captive orca reproduction is a contentious topic due to the potential health and welfare concerns for the animals. In this scientific essay, we review the reproductive biology of orca whales in captivity, the health and welfare concerns associated with captivity, and the ethical considerations of keeping these intelligent and social animals in captivity for human entertainment. Our review highlights the need for continued research to improve the welfare of captive orcas and the conservation efforts of wild populations.
A stability indicating RP-HPLC method development and validation for simultaneous quantification for assay of rifampicin in pharmaceutical solid dosage form
Authors: Nazmus Sakib Chowdhury MD
Published: April 2023

A cost effective stability indicating reverse phase high performance liquid chromatography (RP-HPLC) for simultaneous quantification for assay of Rifampicin in pharmaceutical solid dosage form (tablets) was developed and validated. Chromatographic procedure was conducted using stationary phase packing c18 column (Luna), having 5 µm particle size with inner diameter (250 x 4.6) mm, mobile phase consists of 60% acetate buffer (pH 4.5) and 40% acetonitrile (HPLC grade of sharlau manufacturer). The detection wavelength was uv 254 nm with flow rate of 1.0 ml/min and injection volume was 10 µL with run time 10 min. Based on proposed method validation was conducted following system precision, specificity or selectivity, method precision, accuracy, linearity, robustness, solution stability, limit of quantitation (LOQ), limit of detection. It was observed the system (Waters, HPLC) was precise enough to quantify Rifampicin, no interference of blank, placebo or other known impurity at the elution zone of Rifampicin; % RSD for six sample solutions of Rifampicin was 0.9% (% average assay: 98.7%); accuracy observed 101.1% for 80% recovery, 100.4% for 100% recovery and 100.5% for 120% recovery; co-relation coefficient of linearity (r =1.000); limit of quantification (LOQ) found 0.18 ppm.
Peranan Kawasan Industri dalam Mengatasi Gejala Deindustrialisasi
Authors:   Direktorat Perwilayahan Industri, Kementerian Perindustrian, Winardi Winardi , Priyarsono D. S. ,   Program Studi Ilmu Perencanaan dan Pembangunan Wilayah Perdesaan, Sekolah Pascasarjana, Institut Pertanian Bogor, Siregar Hermanto ,   Program Studi Ilmu Perencanaan dan Pembangunan Wilayah Perdesaan, Sekolah Pascasarjana, Institut Pertanian Bogor, Kustanto Heru ,   Pusat Penelitian dan Pengembangan Industri Agro, Kementerian Perindustrian
Published: April 2023

Kawasan industri merupakan salah satu faktor penentu dalam perkembangan industri manufaktur pada suatu wilayah. Secara teoretis, perusahaan industri yang berlokasi di kawasan industri berdampak pada peningkatkan produktivitas, nilai tambah, efisiensi, dan pendapatan ekonomi suatu wilayah. Penelitian ini bertujuan untuk menganalisis peranan kawasan industri dalam mengatasi gejala deindustrialisasi dengan Model Social Accounting Matrix. Hasil analisis menunjukkan bahwa kawasan industri mempunyai peranan penting dalam peningkatan output perekonomian dan penyerapan tenaga kerja yang lebih besar, sehingga secara tidak langsung akan berdampak pada percepatan proses industrialisasi sekaligus mengatasi gejala deindustrialisasi.
PENGARUH GAME ONLINE TERHADAP KEPRIBADIAN SOSIAL ANAK USIA SEKOLAH DASAR
Authors: Sajidah Lusiana
Published: April 2023

Pada Era Globalisasi saat ini, teknologi menjadi kebutuhan dasar manusia yang didukung melalui perkembangan ilmu pengetahuan yang sangat pesat. Hal ini dikarenakan adanya inovasi dan penemuan yang sederhana. Hingga saat ini perkembangan teknologi, membawa banyak pengaruh bagi pelajar. Salah satunya yaitu dengan kehadiran game online. Permainan ini dapat mempengaruhi kepribadian sosial anak. Dikarenakan permainan game online mempunyai sifat adiktif atau membawa candu, yang mengakibatkan anak yang sudah mengenal game online akan mudah terpengaruh, baik secara langsung maupun tidak.Game online yang menggunakan media elektronik sangat cepat mempengaruhi perkembangan anak. Anak-anak lebih memilih untuk memainkan game online dan meninggalkan permainan tradisional, dikarenakan game tersebut menjadi daya tarik sendiri bagi anak-anak. Game online juga mempunyai dampak yang besar terutama pada perkembangan anak dan jiwa seseorang. Dampak positif dari game online bagi pelajar yaitu pergaulan anak akan menjadi lebih mudah di awasi oleh orang tua, Dampak negatif dari game online bagi pelajar yaitu anak akan malas belajar dan sering menggunakan waktu luang untuk bermain game online.Jenis penelitian ini penelitian kualitatif, pengumpulan data melalui wawancara, dokumentasi, dan observasi. Wawancara dilakukan dengan menanyakan secara langsung kepada subyek penelitian, observasi dilakukan dengan cara mengamati dan mencatat keadaan yang bersangkutan dengan subyek penelitian. Data yang diperoleh dianalisa dengan menggunakan teknik uji kredibilitas (Creadibility), uji dependalitas (Dependibility), uji konformabilitas (Conformability).
Sifat Fisis dan Mekanis Papan Partikel Berbahan Serbuk Tempurung Kelapa (Cocos nucifera L.) dan Serbuk Kayu Ulin (Eusideroxylon zwaregi) Bertulang Anyaman Bambu
Authors: Fazri Icha Zahratul , Mora Mora
Published: April 2023

Penelitian ini dilakukan bertujuan untuk menganalisis sifat fisis dan mekanis papan partikel berbahan serbuk tempurung kelapa dan serbuk kayu ulin bertulang anyaman bambu. Perbandingan komposisi filler yang digunakan serbuk tempurung kelapa : serbuk kayu ulin yaitu 0%:70%, 20%:50%, 35%:35%, 50%:20%, 70%:0% dengan variasi matriks resin epoksi konstan yaitu 30%. Ukuran partikel serbuk tempurung kelapa dan serbuk kayu ulin yang digunakan adalah lolos ayakan 100 mesh. Parameter yang diukur adalah densitas, kadar air, daya serap air, Modulus of Elasticity (MOE), dan Modulus of Repture (MOR). Hasil pengujian yang didapatkan bahwa variasi komposisi serbuk tempurung kelapa dan serbuk kayu ulin berpengaruh terhadap sifat fisis dan mekanis papan partikel. Hasil pengujian sifat fisis papan partikel yang didapatkan memenuhi standar SNI 03-2105-2006 berdasarkan kadar air daya serap air sedangkan densitas belum memenuhi standar SNI 03-2105-2006. Hasil pengujian sifat mekanis papan partikel yang didapatkan MOE dan MOR belum memenuhi standar SNI 03-2105-2006.
Analisis Risiko Gempa Bumi di Kota Pariaman Provinsi Sumatera Barat
Authors: Baihaqi Rahmad , Pujiastuti Dwi
Published: April 2023

Telah dilakukan penelitian Analisis Risiko Gempa Bumi di Kota Pariaman Provinsi Sumatera Barat menggunakan metode PSHA (Probabilictic Seismic Hazard Analysis) untuk memetakan risiko gempa bumi. Metode ini dilakukan dengan memperhitungkan ketidakpastian lokasi, ukuran, dan frekuensi terjadinya gempa bumi.Â  Data yang digunakan berupa data gempa bumi dari katalog gempa bumi BMKG, IRIS, dan USGS dalam periode waktu tahun 1918-2021. Nilai percepatan gerakan tanah maksimum (PGA) akan dicari menggunakan rumus fungsi atenuasi yang didasarkan pada sumber gempa dengan menggunakan bobot ketidakpastian logic tree. Hasil yang diperoleh untuk nilai b-value sebesar 0,851 menunjukkan kerapuhan batuan pada sumber gempa. Nilai a-value sebesar 6,76 menunjukkan aktivitas seismik yang tinggi. Nilai PGA diperoleh sebesar 0,24-0,53gal di Kota Pariaman. Hasil PGA yang diperoleh menunjukkan bahwa Kota Pariaman memiliki nilai risiko gempa bumi sedang. Nilai Intensitas gempa bumi diperoleh sebesar 5,388-5,907 MMI di Kota Pariaman.
Criteria-Based Rehabilitation Following Revision Hip Arthroscopy: A Clinical Commentary
Authors: Leo Haley , Shelton Trevor , Bradley Helen
Published: April 2023

Hip revision arthroscopy is becoming an increasingly popular surgery for those with unsatisfactory outcomes following primary hip arthroscopy. With the relatively uncommon but potentially increased difficulty of rehabilitation from this surgery, a lack of established research regarding rehabilitative programs remains. Therefore, the purpose of this clinical commentary is to propose a criterion-based progression that considers the intricacies present following a hip revision arthroscopy from early rehabilitation through return to sport. Criteria are presented clearly to promote objective progression through rehabilitation as opposed to relying on time since surgery as revision surgeries do not always follow traditional tissue healing time-frames. This criterion based progression promotes range of motion (ROM), strength, gait, neuromuscular control, load introduction and gradual return to play.

Level of Evidence

5
Muscle Strength, Oxygen Saturation and Physical Activity in Patients with Chronic Exertional Compartment Syndrome Compared to Asymptomatic Controls
Authors: Tønning Lisa Urup , Mygind-Klavsen Bjarne , Kjeldsen Troels , Dalgas Ulrik , Brincks John , Mechlenburg Inger
Published: April 2023

Background

One of the most common causes of exercise-induced pain in the lower leg is chronic exertional compartment syndrome (CECS). Research is limited on muscle strength, oxygen saturation and physical activity in patients with CECS.

Purpose

To compare muscle strength, oxygen saturation, and daily physical activity between patients with CECS and matched asymptomatic controls. A secondary purpose was to investigate the association between oxygen saturation and lower leg pain in patients with CECS.

Study Design

Case-control study.

Method

Maximal isometric muscle strength of the ankle plantar and dorsiflexors was tested in patients with CECS and sex- and age-matched controls using an isokinetic dynamometer and oxygen saturation (StO2) during running was tested by near infrared spectroscopy. Perceived pain and exertion were measured during the test using the Numeric Rating Scale and Borg Rating of Perceived Exertion scale and the exercise-induced leg pain questionnaire. Physical activity was assessed by accelerometry.

Results

Twenty-four patients with CECS and 24 controls were included. There were no differences in maximal isometric plantar or dorsiflexion muscle strength between patients and controls. Baseline StO2 was 4.5pp (95% CI: 0.7;8.3) lower for patients with CECS than for controls, whereas no difference existed when they experienced pain or reached exhaustion. No differences were found in daily physical activities, except that on average, patients with CECS spent less time cycling daily. During the StO2 measurement, patients experienced pain or reached exhaustion while running significantly earlier than the controls (p<0.001). StO2 was not associated with leg pain.

Conclusion

Patients with CECS have similar leg muscle strength, oxygen saturation and physical activity levels as asymptomatic controls. However, patients with CECS experienced significantly higher levels of lower leg pain than the controls during running, daily activities and at rest. Oxygen saturation and lower leg pain were not associated.

Level of Evidence

Level 3b.
Ecological and Specific Evidence-Based Safe Return To Play After Anterior Cruciate Ligament Reconstruction In Soccer Players: A New International Paradigm
Authors: Forelli Florian , Le Coroller Nicolas , Gaspar Maxime , Memain Geoffrey , Kakavas Georgios , Miraglia Nicholas , Marine Patrice , Maille Pascal , Hewett Timothy E , Rambaud Alexandre JM
Published: April 2023

Existing return to play (RTP) assessments have not demonstrated the ability to decrease risk of subsequent anterior cruciate ligament (ACL) injury after reconstruction (ACLR). RTP criteria are standardized and do not simulate the physical and cognitive activity required by the practice of sport. Most RTP criteria do not include an ecological approach. There are scientific algorithms as the “5 factor maximum model” that can identify risk profiles and help reduce the risk of a second anterior cruciate ligament injury. Nevertheless, these algorithms remain too standardized and do not include the situations experienced in games by soccer players. This is why it is important to integrate ecological situations specific to the environment of soccer players in order to evaluate players under conditions closest to their sporting activity, especially with high cognitive load. One should identify high risk players under two conditions: Clinical analyses commonly include assessments such as isokinetic testing, functional tests (hop tests, vertical force-velocity, profile), running, clinical assessments (range of motion and graft laxity), proprioception and balance (Star Excursion Balance Test modified, Y-Balance, stabilometry) and psychological parameters (kinesophobia, quality of life and fear of re-injury). Field testing usually includes game simulation, evaluation under dual-task conditions, fatigue and workload analysis, deceleration, timed-agility-test and horizontal force-velocity profiles. Although it seems important to evaluate strength, psychological variables and aerobic and anaerobic capacities, evaluation of neuromotor control in standard and ecological situations may be helpful for reducing the risk of injury after ACLR. This proposal for RTP testing after ACLR is supported by the scientific literature and attempts to approximate the physical and cognitive loads during a soccer match. Future scientific investigation will be required to demonstrate the validity of this approach.

Level of Evidence

5
The Development of a Return to Performance Pathway Involving A Professional Soccer Player Returning From A Multi-Structural Knee Injury: A Case Report
Authors: Mitchell Andrew , Waite Ollie , Holding Craig , Greig Matt
Published: April 2023

This case report describes a male professional soccer player returning to match play (English Championship League) following a medial meniscectomy that occurred during the course of rehabilitation after Anterior Cruciate Ligament (ACL) reconstruction. The player underwent a medial meniscectomy eight months into an ACL rehabilitation program and following 10 weeks of rehabilitation successfully returned to competitive first team match play. This report outlines description of the pathology, the rehabilitation progressions, and the sports specific performance requirements of the player as they progressed through the return to performance pathway (RTP).

The RTP pathway included nine distinct phases with evidenced based criteria required to exit each phase. The first five phases were indoor as the player progressed from the medial meniscectomy, through the rehabilitation pathways to the “gym exit Phase”. The gym exit Phase was assessed with multiple criteria: a) capacity; b) strength; c) isokinetic dynamometry (IKD); d) hop test battery; e) force plate jumps; and f) supine isometric hamstring rate of force (RFD) development qualities to evaluate the players readiness to start sport specific rehabilitation. The last four phases of the RTP pathway are designed to regain the maximal physical capabilities (plyometric and explosive qualities) in the gym and included the retraining of on-field sport specific qualities utilizing the ‘control-chaos continuum.’ The player successfully returned to team play in the ninth and final phase of the RTP pathway. The purpose of this case report was to outline a RTP for a professional soccer player who successfully restored specific injury criteria (strength, capacity and movement quality), physical capabilities (plyometric and explosive qualities). and on-field sport specific criteria utilizing the ‘control-chaos continuum.’

Level of Evidence

Level 4
Self-Movement Screening using the Symmio Application is Reliable and Valid for Identifying Musculoskeletal Risk Factors
Authors: Matsel Kyle , Kirsch Jonathan , Netelbeek Tessa , Rodriguez Rolando , Velic Ervin , Schwartzkopf-Phifer Kate
Published: April 2023

Background

Musculoskeletal health problems are one of the greatest healthcare expenses in the United States but patient-driven screening procedures to detect risk factors do not exist.

Hypothesis/Purpose

The purpose was to establish the inter-rater reliability of the Symmio Self-Screen application in untrained individuals and to investigate its accuracy to detect MSK risk factors such as pain with movement, movement dysfunction, and decreased dynamic balance.

Study Design

Cross-Sectional

Methods

Eighty (42 male, 38 female) healthy individuals mean age 26.5 ± 9.4 participated in the study. The inter-rater reliability of Symmio application was established by comparing self-screen scores from untrained subjects with the results simultaneously determined by a trained healthcare provider. Each subject was evaluated for pain with movement, movement dysfunction, and deficits in dynamic balance by two trained evaluators who were blinded to the Symmio results. The validity of Symmio was determined by comparing self-screen performance dichotomized as pass or fail with the reference standard of pain with movement, failure on the Functional Movement Screen™, and asymmetry on the Y Balance Test-Lower Quarter™ using three separate 2x2 contingency tables.

Results

The mean Cohen’s kappa coefficient was 0.68 (95% CI, 0.47-0.87) and the absolute agreement was 89% between self-assessment of subjects and the observation of a trained healthcare provider. There were significant associations for the presence of pain with movement (p=0.003), movement dysfunction (p=0.001), and dynamic balance deficits (p=0.003) relative to poor Symmio performance. The accuracy of Symmio to identify pain with movement, movement dysfunction, and dynamic balance deficits were 0.74 (95% CI, 0.63-0.83), 0.73 (95% CI, 0.62-0.82), and 0.69 (95% CI, 0.57-0.79), respectively.

Conclusions

The Symmio Self-Screen application is a reliable and feasible screening tool that can be used to identify MSK risk factors.

Level of Evidence

Level 2