bluuebunny/crossref_metadata_2025 huggingface dataset:
NOTCH1 Signalling: A key pathway for the development of high-risk chronic lymphocytic leukaemia
Authors: Edelmann Jennifer
Published: October 2022

NOTCH1 is a cell surface receptor that releases its intracellular domain as transcription factor upon activation. With the advent of next-generation sequencing, the NOTCH1 gene was found recurrently mutated in chronic lymphocytic leukaemia (CLL). Here, virtually all NOTCH1 mutations affect the protein’s PEST-domain and impair inactivation and degradation of the released transcription factor, thus increasing NOTCH1 signalling strength. Besides sequence alterations directly affecting the NOTCH1 gene, multiple other genomic and non-genomic alterations have by now been identified in CLL cells that could promote an abnormally strong NOTCH1 signalling strength. This renders NOTCH1 one of the key signalling pathways in CLL pathophysiology. The frequency of genomic alterations affecting NOTCH1 signalling is rising over the CLL disease course culminating in the observation that besides TP53 loss, 8q gain and CDKN2A/B loss, NOTCH1 mutation is a hallmark genomic alteration associated with transformation of CLL into an aggressive lymphoma (Richter transformation). Both findings associate de-regulated NOTCH1 signalling with the development of high-risk CLL. This narrative review provides data on the role of NOTCH1 mutation for CLL development and progression, discusses the impact of NOTCH1 mutation on treatment response, gives insight into potential modes of NOTCH1 pathway activation and regulation, summarises alterations that have been discussed to contribute to a de-regulation of NOTCH1 signalling in CLL cells and provides a perspective on how to assess NOTCH1 signalling in CLL samples.
Identification of prognostic factors for predicting survival of patients with malignant adrenal tumors: A population-based study
Authors: Wang Keyi , Zhang Tao , Ni Jinliang , Chen Jianghong , Zhang Houliang , Wang Guangchun , Gu Yongzhe , Peng Bo , Mao Weipu , Wu Jianping
Published: October 2022

Background

This study aimed to identify the prognostic factors for overall survival (OS) and cancer-specific survival (CSS) in patients with malignant adrenal tumors and establish a predictive nomogram for patient survival.

Methods

The clinical characteristics of patients diagnosed with malignant adrenal tumors between 1988 and 2015 were retrieved from the Surveillance, Epidemiology and End Results (SEER) database. As the external validation set, we included 110 real-world patients from our medical centers. Univariate and multivariate Cox regressions were implemented to determine the prognostic factors of patients. The results from Cox regression were applied to establish the nomogram.

Results

A total of 2,206 eligible patients were included in our study. Patients were randomly assigned to the training set (1,544; 70%) and the validation set (662; 30%). It was determined that gender, age, marital status, histological type, tumor size, SEER stage, surgery, and chemotherapy were prognostic factors that affected patient survival. The OS prediction nomogram contained all the risk factors, while gender was excluded in the CSS prediction nomogram. The receiver operating characteristic (ROC) curve and decision curve analysis (DCA) indicated that the nomogram had a better predictive performance than SEER stage. Moreover, the clinical impact curve (CIC) showed that the nomograms functioned as effective predictive models in clinical application. The C-index of nomogram for OS and CSS prediction was 0.773 (95% confidence interval [CI]: 0.761–0.785) and 0.689 (95% CI: 0.675–0.703) in the training set. The calibration curves exhibited significant agreement between the nomogram and actual observation. Additionally, the results from the external validation set also presented that established nomograms functioned well in predicting the survival of patients with malignant adrenal tumors.

Conclusions

The following clinical variables were identified as prognostic factors: age, marital status, histological type, tumor size, SEER stage, surgery, and chemotherapy. The nomogram for patients with malignant adrenal tumors contained the accurate predictive performance of OS and CSS, contributing to optimizing individualized clinical treatments.
Patient initiated follow-up in cancer patients: A systematic review
Authors: Newton Claire , Beaver Kinta , Clegg Andrew
Published: October 2022

Background

Patient-initiated follow-up (PIFU) is increasingly being implemented for oncology patients, particularly during the COVID-19 pandemic, given the necessary reduction in face-to-face hospital outpatient appointments. We do not know if PIFU has a positive (or negative) impact on overall, or progression free, survival.

Objectives

To investigate the impact of PIFU on overall survival, progression free survival, patient satisfaction, psychological morbidity, specifically quality of life (QoL) and economic costs compared to hospital follow up (HFU), for any type of cancer.

Methods

We carried out a systematic review using five electronic databases: MEDLINE, CINAHL, EMBASE, PsycInfo and Cochrane Central Register of Controlled Trials. Studies were eligible if they were controlled clinical trials comparing PIFU with another form of active follow-up. Effectiveness was assessed using the primary outcome of overall survival and secondary outcomes of progression free survival, patient satisfaction, psychological morbidity, QoL and cost effectiveness.

Results

Eight studies met the inclusion criteria and were included. Only one study included survival as a primary outcome and indicated no significant differences between hospital-based follow-up and PIFU, although not adequately powered to detect a difference in survival. For secondary outcomes, few differences were found between PIFU and other forms of active follow-up. One study reported significant differences in fear of cancer recurrence between PIFU and HFU although did not reach the limit of clinical significance; in the short term, fear decreased significantly more in hospital based follow-up.

Conclusion

We do not have evidence to support the impact of PIFU on survival or progression free survival. Fully powered randomized controlled trials are required to determine the full impact of PIFU in the longer term.
Efficacy of an elasto-flexible morphing wing at high lift using fluid-structure-interaction simulations
Authors: Pflüger J. , Von Langsdorff M. , Breitsamter C.
Published: October 2022

The wide field of applications is the driving force behind the scientific interest in unmanned and micro air vehicles. For these aircraft, morphing wing technologies offer the possibility to adapt the aerodynamics to different flight stages. A morphing wing configuration with two elasto-flexible membrane wings is investigated numerically at a low Reynolds number of Re = 264000. The concept enables wing folding over a wide range and it allows the wing to adapt to changing aerodynamic loads. The focus is set on the benefits of the membrane in the high lift regime. Therefore, fluid-structure-interaction simulations are performed for the model equipped with a flexible and with a rigid wing. The comparison of the numerical results to data from previous experimental measurements show a good agreement. Compared with the rigid wing, the elasto-flexible membrane increases the gradient in the linear region and the maximum lift coefficient. In addition, the maximum lift coefficient is shifted to higher angles of attack. For selected wing positions and angles of attack, the aerodynamic behavior of the flexible and the rigid wing are investigated by means of the lift coefficient, the deformation of the membrane, the wall shear stresses and the wing surface pressure distribution. The deformation of the wing surface directly influences the area of flow separation at the extended wing and the separating leading-edge vortex at the folded wing. Both effects increase the generated lift of the wing with a flexible membrane.
Oxaloacetate acid ameliorates paraquat-induced acute lung injury by alleviating oxidative stress and mitochondrial dysfunction
Authors: Li Wenwen , Li Mengxuan , Chen Kaiyuan , Tang Yahui , Yin Ran , Lan Linhua , Hong Guangliang
Published: October 2022

Acute lung injury (ALI) is the primary cause of death among patients with acute paraquat (PQ) poisoning, whereby peroxidative damage is an important mechanism underlying PQ-induced lung injury. There is a lack of effective interventional drugs for patients with PQ poisoning. Oxaloacetic acid (OAA) participates in multiple in vivo metabolic processes, whereby it facilitates the clearance of reactive oxygen species (ROS) and improves mitochondrial function. The study aimed to assess the protective effects of OAA on PQ-induced ALI and elucidate the underlying molecular mechanism. Our data demonstrated that OAA treatment significantly alleviated PQ-induced ALI and improved the survival rate of PQ-poisoned mice, and also alleviated PQ-induced cellular oxidative stress and mitochondrial dysfunction. OAA-mediated alleviation of PQ-induced mitochondrial dysfunction depends on the following mechanisms which may explain the above findings: 1) OAA effectively cleared intracellular ROS, inhibited ROS accumulation, and mitochondrial depolarization; 2) OAA inhibited the downregulation of L-OPA1 and MFN2 caused by PQ and promoted a dynamic balance of mitochondrial fusion and fission, and 3) the expression of PGC-1α, TFAM, COX2, and COX4I1, increased significantly following OAA intervention which improved mitochondrial respiratory functions and promoted its biogenesis and energy metabolism in damaged cells. In conclusion, OAA effectively cleared ROS and improved mitochondrial dysfunction, thereby significantly improving ALI caused by PQ poisoning and the animal survival rate. Therefore, OAA may be a potential drug for the treatment of PQ poisoning.
Terpenoid natural products exert neuroprotection via the PI3K/Akt pathway
Authors: Xu Bingyao , Bai Lan , Chen Lu , Tong Rongsheng , Feng Yibin , Shi Jianyou
Published: October 2022

PI3K/Akt, an essential signaling pathway widely present in cells, has been shown to be relevant to neurological disorders. As an important class of natural products, terpenoids exist in large numbers and have diverse backbones, so they have a great chance to be identified as neuroprotective agents. In this review, we described and summarized recent research for a range of terpenoid natural products associated with the PI3K/Akt pathway by classifying their basic chemical structures of the terpenes, identified by electronic searches on PubMed, Web of Science for research, and Google Scholar websites. Only articles published in English were included. Our discussion here concerned 16 natural terpenoids and their mechanisms of action, the associated diseases, and the methods of experimentation used. We also reviewed the discovery of their chemical structures and their derivatives, and some compounds have been concluded for their structure–activity relationships (SAR). As a result, terpenoids are excellent candidates for research as natural neuroprotective agents, and our content will provide a stepping stone for further research into these natural products. It may be possible for more terpenoids to serve as neuroprotective agents in the future.
Terpenes as bacterial efflux pump inhibitors: A systematic review
Authors: Dias Kaio Jefté Santos De Oliveira , Miranda Gustavo Marinho , Bessa Jonatas Reis , Araújo Ana Carolina Justino De , Freitas Priscilla Ramos , Almeida Ray Silva De , Paulo Cícera Laura Roque , Neto José Bezerra De Araújo , Coutinho Henrique D. M. , Ribeiro-Filho Jaime
Published: October 2022

Managing antibiotic resistance is a significant challenge in modern pharmacotherapy. While molecular analyses have identified efflux pump expression as an essential mechanism underlying multidrug resistance, the targeted drug development has occurred slower. Thus, considering the verification that terpenes can enhance the activity of antibiotics against resistant bacteria, the present study gathered evidence pointing to these natural compounds as bacterial efflux pump inhibitors. A systematic search for manuscripts published between January 2007 and January 2022 was carried out using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol and the following search terms: “Terpene”; AND “Efflux pump”; and “Bacteria.” From a total of 101 articles found in the initial search, 41 were included in this review. Seventy-five different terpenes, 63 bacterial strains, and 22 different efflux pumps were reported, with carvacrol, Staphylococcus aureus SA-1199B, and NorA appearing most frequently mentioned terpene, bacterial strain, and efflux pump (EP), respectively. The Chi-Squared analysis indicated that terpenes are significantly effective EP inhibitors in Gram-positive and Gram-negative strains, with the inhibitory frequency significantly higher in Gram-positive strains. The results of the present review suggest that terpenes are significant efflux pump inhibitors and, as such, can be used in drug development targeting the combat of antibacterial resistance.
Licoricidin combats gastric cancer by targeting the ICMT/Ras pathway in vitro and in vivo
Authors: Ma Hanwei , Wu Fahong , Bai Yinliang , Wang Tianwei , Ma Shangxian , Guo Liuqing , Liu Guiyuan , Leng Guangxian , Kong Yin , Zhang Youcheng
Published: October 2022

Licoricidin, a type of isoflavonoid, is extracted from the root of Glycyrrhiza glabra. It has been widely proven that licoricidin possesses multiple biological activities, including anti-cancer effects and a powerful antimicrobial effect against Helicobacter pylori (H. pylori). However, the exact mechanism of licoricidin against gastric cancer remains unclear. In this study, we comprehensively explored the effects of licoricidin on MGC-803 gastric cancer cells in vitro and in vivo and further elucidated its mechanism of action. Our results revealed that licoricidin exhibited multiple anti-gastric cancer activities, including suppressing proliferation, inducing apoptosis, arresting the cell cycle in G0/G1 phase, and inhibiting the migration and invasion abilities of MGC-803 gastric cancer cells. In addition to this, a total of 5861 proteins were identified by quantitative proteomics research strategy of TMT labeling, of which 19 differential proteins (two upregulated and 17 downregulated) were screened out. Combining bioinformatics analyses and the reported roles in cancer progression of the 19 proteins, we speculated that isoprenyl carboxyl methyltransferase (ICMT) was the most likely target of licoricidin. Western blot assays and IHC assays subsequently proved that licoricidin significantly downregulated the expression of ICMT, both in MGC-803 cells and in xenograft tumors. Moreover, licoricidin effectively reduced the level of active Ras-GTP and blocked the phosphorylation of Raf and Erk, which may be involved in its anti-gastric cancer effects. In summary, we first demonstrated that licoricidin exerted favorable anti-gastric cancer activities via the ICMT/Ras pathway, which suggests that licoricidin, as a natural product, could be a novel candidate for the management of gastric cancer.
Combined contact force and local impedance dynamics during repeat atrial fibrillation catheter ablation
Authors: Alken Fares-Alexander , Scherschel Katharina , Kahle Ann-Kathrin , Masjedi Mustafa , Meyer Christian
Published: October 2022

Background: Optimal lesion formation during catheter-based radiofrequency current (RFC) ablation depends on electro-mechanical tip-tissue coupling measurable via contact force (CF) and local impedance (LI) monitoring. We aimed to investigate CF and LI dynamics in patients with previous atrial fibrillation (AF) ablation who frequently present with heterogenous arrhythmia substrate.

Methods: Data from consecutive patients presenting for repeat AF or atrial tachycardia ablation using a novel open-irrigated single-tip ablation catheter were studied. RFC applications were investigated regarding CF, LI and the maximum LI drop (∆LI) for evaluation of ablation efficacy. ∆LI > 20 Ω was defined as a successful RFC application.

Results: A total of 730 RFC applications in 20 patients were analyzed. Baseline CF was not associated with baseline LI (R = 0.06, p = 0.17). A mean CF < 8 g during ablation resulted in lower ∆LI (<8 g: 13 Ω vs. ≥ 8 g: 16 Ω, p < 0.001). Baseline LI showed a better correlation with ∆LI (R = 0.35, p < 0.001) compared to mean CF (R = 0.17, p < 0.001). Mean CF correlated better with ∆LI in regions of low (R = 0.31, p < 0.001) compared to high (R = 0.21, p = 0.02) and intermediate voltage (R = 0.17, p = 0.004). Combined CF and baseline LI predicted ∆LI > 20 Ω (area under the receiver operating characteristic curve (AUC) 0.75) better compared to baseline LI (AUC 0.72), mean CF (AUC 0.60), force-time integral (AUC 0.59) and local bipolar voltage (0.55).

Conclusion: Combination of CF and LI may aid monitoring real-time catheter-tissue electro-mechanical coupling and lesion formation within heterogenous atrial arrhythmia substrate in patients with repeat AF or atrial tachycardia ablation.
GhBEE3-Like gene regulated by brassinosteroids is involved in cotton drought tolerance
Authors: Chen Eryong , Yang Xiaobei , Liu Ruie , Zhang Mengke , Zhang Meng , Zhou Feng , Li Dongxiao , Hu Haiyan , Li Chengwei
Published: October 2022

Brassinosteroids (BRs) are important phytohormones that play a vital role in plant drought tolerance, but their mechanisms in cotton (Gossypium hirsutum L.) are poorly understood. Numerous basic helix-loop-helix (bHLH) family genes are involved in the responses to both BRs and drought stress. GhBEE3-Like, a bHLH transcription factor, is repressed by both 24-epi-BL (an active BR substance) and PEG8000 (drought simulation) treatments in cotton. Moreover, GhBZR1, a crucial transcription factor in BR signaling pathway, directly binds to the E-box element in GhBEE3-Like promoter region and inhibits its expression, which has been confirmed by electrophoretic mobility shift assay (EMSA) and dual luciferase reporter assay. Functional analysis revealed that Arabidopsis with GhBEE3-Like overexpression had drought sensitive phenotype, while GhBEE3-Like knock-down cotton plants obtained by virus-induced gene silencing (VIGS) technology were more tolerant to drought stress. Furthermore, the expression levels of three stress-related genes, GhERD10, GhCDPK1 and GhRD26, were significantly higher in GhBEE3-Like knock-down cotton than in control cotton after drought treatment. These results suggest that GhBEE3-Like is inhibited by BRs which elevates the expressions of stress-related genes to enhance plant drought tolerance. This study lays the foundation for understanding the mechanisms of BR-regulated drought tolerance and establishment of drought-resistant cotton lines.
The performance of Miscanthus hybrids in saline-alkaline soil
Authors: Zheng Cheng , Yi Zili , Xiao Liang , Sun Guorong , Li Meng , Xue Shuai , Peng Xiaoying , Duan Meijuan , Chen Zhiyong
Published: October 2022

Cultivating the dedicated biomass crop Miscanthus on marginal land is a sustainable means of avoiding competition with food crops for arable land. A large proportion of global marginal land is saline–alkaline; however, little is known about the performance of Miscanthus in saline-alkaline soil. In this study, Miscanthus × giganteus and ten other Miscanthus hybrids grown in the Yellow River Delta were exposed to low and saline–alkaline soils during the 2016–2018 growing season to evaluate the agronomic traits, biomass quality and the potential productive index of eleven Miscanthus genotypes. Plant biomass, plant height, and tiller number significantly decreased in high saline–alkaline soil. In particular, the average plant biomass of ten Miscanthus hybrids in low saline–alkaline soil in 2017 and 2018 were 0.21 and 2.25 kg per plant, respectively, and in high saline-alkaline soil were 0.13 and 0.65 kg per plant, respectively. Cell wall, cellulose, and nitrogen content of all genotypes significantly decreased in high saline–alkaline soil, while hemicellulose, ash, sodium, potassium, magnesium, and calcium content significantly increased. However, high saline–alkaline soil had no observable impact on lignin content of Miscanthus biomass. The effect of high saline-alkaline on biomass quality parameters could provide important information for the application of Miscanthus biomass in saline-alkaline soil. The selected genotypes (A5) could be considered as breeding materials in saline-alkaline soil.
Mapping QTLs for anaerobic tolerance at germination and bud stages using new high density genetic map of rice
Authors: Yang Jing , Wei Ji , Xu Jifen , Xiong Yumeng , Deng Gang , Liu Jing , Fahad Shah , Wang Hongyang
Published: October 2022

Due to its low cost and convenience, direct seeding is an efficient technique for the production of rice in different rice growing areas. However, anaerobic conditions are a major obstacle to the direct seeding of rice and result in poor seedling establishment, which leads to yield losses. We constructed a collection of recombinant inbred lines (RIL) comprising 275 lines derived from the H335 and CHA-1 cross by the method of single seed descent. Via a genotyping-by-sequencing (GBS) strategy, a high-density genetic map containing 2498 recombination bin markers was constructed, the average physical distance between the markers was only 149.38 Kb. After anaerobic treatment, 12 phenotypes related to both the coleoptile at germination and seedling quality at budding were evaluated. There were no significant correlations between seedling and bud traits. Genetic mapping of quantitative traits was performed for these traits across two cropping seasons. A total of 20 loci were detected, named locus 1~20. Three of them were repeatedly detected across both seasons. Six loci overlapped with those in previous reports, and nine loci were associated with multiple traits at both stages. Notably, locus 3, which is located on chromosome 2 (26,713,837 to 27,333,897 bp), was detected for both the germination and bud traits. By focusing on the locus 3 interval and by combining gene annotation and expression analyses, we identified a promising candidate gene, trehalose-6-phosphate phosphatase (OsTPP1, LOC_Os02g44230). Furthermore, RILs (G289, G379, G403, G430 and G454) that have superior phenotypes and that pyramid elite alleles were recognized. The findings of present study provide new genetic resources for direct-seeding rice (DSR) varieties for molecular breeding strategies and expand our knowledge of genetic regulation of seedling establishment under anaerobic conditions.
Neuroscience on breaking bad news: Effects of physicians’ response on patient emotion and trust
Authors: Song Yan , Xiu Yifan , Li Wei , Wang Fang
Published: October 2022

Background

The outbreak of COVID-19, due to restrictions on patients’ access to hospitals, makes patient mental health a severe problem to solve, especially for cancer patients. Delivering bad news has become one of the abilities that physicians need to improve. Former research has proposed communication strategies like SPIKES to respond to patients’ emotions. However, existing strategies lack systematic and structural responses to different cues and concerns of patients.

Objective

This study aims to investigate whether and how the response styles of information delivery, empathy, and authority affect patient emotions and trust in order to present a structural response system. Furthermore, we explore the correlation between strategies and EEG markers to moderate emotions and trust.

Methods

This research selects different scenarios and strategies in the context of breast cancer and performs two experiments. First, we performed a behavioral experiment with 93 medical students and 15 breast cancer patients. Moreover, an EEG experiment with 53 students via video stimuli was conducted to explore the moderate function between strategies and emotions/trust. We use time-frequency analysis and the repeated measure ANOVA method to explore the association between strategy and EEG components. Furthermore, we perform a GLM method to investigate the relationship between EEG components and patient emotion and trust.

Results

For the first time, this study proposes the strategy matrix. The response strategies NPIm and NRIa play important roles in this system. In behavioral experiments, information delivery, empathy, and authority strategy significantly affect emotions and trust. The scenario is significant as a moderator. In the EEG experiment, strategy NPIm has more correlation with parietal alpha power than other strategies, and parietal alpha power has a significant effect on emotions, which verifies that empathy-related cerebral activities affect emotions and trust.

Conclusion

According to the strategy matrix, physicians could apply strategy ERIa in most scenarios, and strategy NRIa in many scenarios, which means information provision is significant when it comes to responding to patients’ cues and concerns. The most important strategy that physicians need to avoid is the authority strategy. Refusing to respond to patients’ cues and concerns may cause their dislike. Moreover, through the EEG experiment, we verify that empathy affects emotions and trust from a neuroscience perspective and propose parietal alpha and frontal alpha as neuro-markers to moderate emotions and trust. Physicians could adjust strategies through these EEG markers.
Language interpretation in travel guidance platform: Text mining and sentiment analysis of TripAdvisor reviews
Authors: Chu Miao , Chen Yi , Yang Lin , Wang Junfang
Published: October 2022

The opinions and feelings expressed by tourists in their reviews intuitively represent tourists' evaluation of travel destinations with distinct tones and strong emotions. Both consumers and product/service providers need help understanding and navigating the resulting information spaces, which are vast and dynamic. Traditional sentiment analysis is mostly based on statistics, which can analyze the sentiment of a large number of texts. However, it is difficult to classify the overall sentiment of a text, and the context-independent nature limits their representative power in a rich context, hurting performance in Natural Language Processing (NLP) tasks. This work proposes an aspect-based sentiment analysis model by extracting aspect-category and corresponding sentiment polarity from tourists' reviews, based on the Bidirectional Encoder Representation from Transformers (BERT) model. First, we design a text enhancement strategy which utilizes iterative translation across multiple languages, to generate a dataset of 4,000 reviews by extending a dataset of 2,000 online reviews on 1,000 tourist attractions. Then, the enhanced dataset is reorganized into 10 classifications by the Term Frequency-Inverse Document Frequency (TF-IDF) method. Finally, the aspect-based sentiment analysis is performed on the enhanced dataset, and the obtained sentiment polarity classification and prediction of the tourism review data make the expectations and appeals in tourists' language available. The experimental study generates generic and personalized recommendations for users based on the emotions in the language and helps merchants achieve more effective service and product upgrades.
Research on Expressive Writing in Psychology: A Forty-year Bibliometric Analysis and Visualization of Current Status and Research Trends
Authors: Gao Xiaojuan
Published: October 2022

This study offers a systematic review of global academic publications of studies on expressive writing in psychology to date. By using two visualization tools VOSviewer and CiteSpace, we analyzed 1,429 articles on expressive writing from the Web of Science (WoS) Core Collection database. This study might be the first attempt at providing a visualized analysis of the existing expressive writing research. It discusses the results from the following three aspects: (1) the descriptive analysis of general results based on publications, (2) the content analysis based on highly cited articles and keyword analysis, (3) the thematic evolution based on co-word analysis and bursts detection. It is found that the application of expressive writing to minority ethnic groups might be one of the future research interests. The study proposes the necessity of conducting research in the context of positive psychology, argues for a combined use of creative and expressive writing in future studies, and suggests the potential of second/foreign language expressive writing research. The study can be used to enhance researchers’ understanding of expressive writing research and provide insights into future research opportunities in this area.
An examination of dispositional social needs, agent knowledge, and two dimensions of product anthropomorphism: A serial mediation model
Authors: Sohail Sehar , Sajjad Amber , Zafar Sohail
Published: October 2022

Thriving attention has been paid to the process and concept of anthropomorphism in marketing literature, as the concept is considered to be a precursor of positive marketing outcomes. However, prior studies have not clarified the position or role of inductive reasoning and anthropomorphism or explained the relationship between anthropomorphism and consumers' individual dispositions. This paper aims to delve into the relationship between consumer psychological and dispositional motivational traits for a given product advertisement that has been personified and imbued with human body features. Building on the literature, a conceptual model has been proposed in which the psychological process-agent knowledge and dispositional motivation to meet social needs have been taken as independent variables positively related to one another and also related individually to the two distinct dimensions of anthropomorphism (i) physical anthropomorphism and (ii) anthropomorphic thinking. Furthermore, it was empirically tested if these two dimensions and these independent variables are linked in a sequential manner. The results show that the need for belonging is positively associated with agent knowledge acquisition, physical anthropomorphism, and anthropomorphic thinking for a given stimulus. Similarly, agent knowledge induced by a humanized stimulus was also positively associated with the two dimensions of anthropomorphism. Furthermore, the two dimensions had a positive relationship with one another. Finally, the need for belonging is also positively associated with agent knowledge and two dimensions of anthropomorphism in a sequential manner. Findings indicate that marketers need to take into account dispositional and psychological factors which might ultimately affect their anthropomorphic inferences in order to induce anthropomorphic thinking because of which positive marketing outcomes take place.
Why students feel competent in the classroom: A qualitative content analysis of students’ views
Authors: Reymond Nadia Catherine , Nahrgang Ruth Gerlinde , Großmann Nadine , Wilde Matthias , Fries Stefan
Published: October 2022

This qualitative study aimed to identify and to systematize factors that contribute to students’ competence satisfaction in class from students’ perspectives. Based on self-determination theory as our primary theoretical background, we conducted episodic interviews with 25 high school students. A combined deductive-inductive qualitative content analysis approach was applied. As our key finding, we revealed different teaching factors within and beyond self-determination theory (i.e., structure, autonomy support, relatedness support, mastery goal structure, perceived error climate, teaching quality, teachers’ reference norm orientations) as well as additional factors (e.g., students’ motivation and engagement, peer climate and reciprocal peer support) that contributed to students’ competence satisfaction in class from the students’ points of view. This study contributes to existing research on why students’ competence satisfaction arises in class by complementing it with an integrative, explorative, and student-oriented perspective.
International students’ study-related burnout: Associations with perceptions of the teaching-learning environment and approaches to learning
Authors: Yin Yufan , Toom Auli , Parpala Anna
Published: October 2022

International students study in new, unfamiliar teaching-learning environments (TLEs) and may thus experience study-related burnout. However, little research exists on the relationship between perceptions of the TLE and such burnout, especially among international students. Nevertheless, one key factor is thought to be students’ approaches to learning. This study investigated the relationship between international students’ perceptions of the TLE, approaches to learning and study-related burnout and how these approaches mediate the relationship between perceptions of the TLE and burnout. The data were collected among international students (n = 162) in a research-intensive Scandinavian university and analyzed using confirmatory factor analyses and structural equation modelling. The results indicated that international students’ study-related burnout correlated negatively with perceptions of the TLE (alignment, interest and relevance, constructive feedback and peer support). Their study-related burnout was positively related to the unreflective approach to learning and negatively related to the deep approach to learning and organized studying. The study proved that approaches to learning acted as mediators between perceptions of the TLE and study-related burnout. The findings indicated that how the dimensions of study-related burnout were affected by different constructs of perceptions of the TLE and approaches to learning among international students. Based on these findings, the study provides implications for improving teaching. Future research should focus on the relationship between the deep approach to learning and exhaustion and how peer support affects study-related burnout.
A meta-analysis of proactive personality and career success: The mediating effects of task performance and organizational citizenship behavior
Authors: Zhang Zeyu , Fang Han , Luan Yuxiang , Chen Qishu , Peng Jianfeng
Published: October 2022

This study aims to reveal the impact of proactive personality on career success (i.e., subjective career success, salary, and promotion) and the sequential mediation effect of organizational citizenship behavior (OCB) and task performance on the relationship. Utilizing meta-analytic structural equation modeling (MASEM) technology sampling 101,131 employees from multiple organizations and industries, which deeply decreased sampling error, the results indicated slightly different findings of proactive personality and three types of career success. Specifically, in relation to salary, OCB and task performance independently transmit the effects of proactive personality to subjective career success, but they sequentially mediate this link as well. In regard to subjective career success and promotion, OCB (but not task performance) mediates the relationship between proactive personality and promotion. OCB and task performance sequentially mediate these links. We discussed findings cautiously and purpose future research directions.
Association of BDNF and MMP-9 single-nucleotide polymorphisms with the clinical phenotype of schizophrenia
Authors: Pan Lihong , Cao Zhonghai , Chen Lianghu , Qian Min , Yan Yuzhong
Published: October 2022

Objective

Schizophrenia is a highly polygenic psychiatric disorder; however, the complex genetic architecture underlying the pathogenesis remains elusive. Brain-derived neurotrophic factor (BDNF), a neurotrophin, and matrix metalloproteinase 9 (MMP-9), a gelatinase B, are the promising candidate genes for schizophrenia. To shed new light on the relationship between the single-nucleotide polymorphisms (SNPs) of BDNF and MMP-9 and the clinical variability of schizophrenia phenotype, this study aims to evaluate the relationship, and provide more definitive evidence for the relationship with various clinical features of schizophrenia.

Methods

A case-control association study was performed, and one hundred and five subjects of Chinese Han population were enrolled, including 55 schizophrenia patients (SP) and 50 healthy controls (HC). The BDNF rs6265 196 G > A and MMP-9 rs3918242 −1562C > T SNPs were genotyped using PCR-RFLP assay. The Positive and Negative Syndrome Scale (PANSS) was used to assess the clinical symptoms of patients with schizophrenia.

Results

Compared with HC, the frequency of SP carrying BDNF rs6265 GG/GA genotype was significantly higher than HC, and the frequency of SP carrying BDNF rs6265 AA genotype was significantly lower than HC (p < 0.01). With regards to MMP-9 rs3918242 −1562C > T SNP, no significant difference was observed between the control and SP. BDNF GG genotype showed significantly higher PANSS and positive symptoms score than GA and AA genotypes (P < 0.01). MMP-9 CC genotype showed significantly higher PANSS and general score than CT and TT genotypes (P < 0.05).

Conclusion

BDNF rs6265 196 G > A and MMP-9 rs3918242–1562C > T SNPs are related to the clinical features of schizophrenia and could be a useful biomarker for the changes, remission or deterioration of clinical status of schizophrenia.
Chaos analysis of the brain topology in first-episode psychosis and clinical high risk patients
Authors: Korda Alexandra I. , Andreou Christina , Avram Mihai , Handels Heinz , Martinetz Thomas , Borgwardt Stefan
Published: October 2022

Structural MRI studies in first-episode psychosis (FEP) and in clinical high risk (CHR) patients have consistently shown volumetric abnormalities in frontal, temporal, and cingulate cortex areas. The aim of the present study was to employ chaos analysis for the identification of brain topology differences in people with psychosis. Structural MRI were acquired from 77 FEP, 73 CHR and 44 healthy controls (HC). Chaos analysis of the gray matter distribution was performed: First, the distances of each voxel from the center of mass in the gray matter image was calculated. Next, the distances multiplied by the voxel intensity were represented as a spatial-series, which then was analyzed by extracting the Largest-Lyapunov-Exponent (lambda). The lambda brain map depicts thus how the gray matter topology changes. Between-group differences were identified by (a) comparing the lambda brain maps, which resulted in statistically significant differences in FEP and CHR compared to HC; and (b) matching the lambda series with the Morlet wavelet, which resulted in statistically significant differences in the scalograms of FEP against CHR and HC. The proposed framework using spatial-series extraction enhances the between-group differences of FEP, CHR and HC subjects, verifies diagnosis-relevant features and may potentially contribute to the identification of structural biomarkers for psychosis.
Heavy metal contamination assessment and probabilistic health risks in soil and maize near coal mines
Authors: Yang Xiujuan , Cheng Bijun , Gao Yi , Zhang Hongmei , Liu Liangpo
Published: October 2022

Objective

Coal mining activities have continuously introduced heavy metals into the soil–crop system, causing increasing damage to crops. This study integrated the analysis of the heavy metal contamination status and human health risk in soil and maize near coal mines to help formulate control strategies for soil quality, maize production, and safe consumption.

Method

This study was carried out on maize agricultural land near a coal mining plant. Heavy metal contamination was assessed by the geo-accumulation index (Igeo), enrichment factor (EF), and bioaccumulation factor (BCF). The Monte Carlo simulation was used to estimate the probabilistic health risk of heavy metals exposure in soil and maize. The relationship between the concentration of heavy metal in the soil and that in maize was further visualized by correlation analysis and random forest analysis.

Results

The results revealed that the mean concentrations of soil Ni, Cu, As, Cd, Sn, Zn, Pb, and Hg were all above the local background level. Ni was the most severely polluted heavy metal in maize and had a concentration higher than the risk control standard for corn in China (NY 861-2004). The Igeo values of all heavy metals were low, and EF values showed enrichment in V, Cr, Ti, Ni, and As. The assessment of probabilistic health risk exposed by heavy metals in soil and maize indicated that 1.16 and 1.46% of residents exceeded the carcinogenic risk level due to heavy metal exposure from soil and maize, respectively. Children were the most sensitive to maize and soil heavy metal exposure in the contaminated area. Ingestion of heavy metals was associated with the highest health risk to residents, followed by dermal contact and inhalation. As and Cr in soil and Cr and Ni in maize had the greatest impact on human health risk. Furthermore, maize heavy metals were affected the most by soil Cr, Cd, and V.

Conclusion

These results may provide useful information for human carcinogenic risk associated with soil and maize heavy metal exposure due to coal mining activities.
Use of Parthenium hysterophorus with synthetic chelator for enhanced uptake of cadmium and lead from contaminated soils—a step toward better public health
Authors: Ejaz Ujala , Khan Shujaul Mulk , Aqeel Muhammad , Khalid Noreen , Sarfraz Wajiha , Naeem Nayab , Han Heesup , Yu Jongsik , Yue Gong , Raposo António
Published: October 2022

Parthenium hysterophorus L. is a vigorous plant species with cosmopolitan distribution. It can uptake considerable quantities of heavy metals from the soil and accrue these metals in its different tissue. The use of chelating agent i.e., Ethylenediaminetetraacetic acid (EDTA) can boost up metal uptake capacity. Pot experiment was performed to evaluate phytoextraction potential of P. hysterophorus for lead (Pb) and cadmium (Cd) with and without the aid of EDTA chelator. Shoot length, weight of root and shoot (both fresh and dry), leaves number, and chlorophyll contents of P. hysterophorus got reduced with an increase in metal uptake. The results revealed the highest concentration of Cd in shoot without and with EDTA was 283.6 and 300.1 mg kg−1, correspondingly. Increase in Pb concentration was also boosted up by the EDTA from its maximum concentration in shoot 4.30–9.56 mg kg−1. Generally, Pb and Cd concentrations were greater in shoots of P. hysterophorus than the roots regardless of EDTA in the treatments. EDTA also impacted positively the accumulation of essential ions K+, Na+, and Ca+2 in P. hysterophorus. The capacity of P. hysterophorus to accumulate Pb and Cd found to be increased with EDTA in the soil. Bringing metals level in the soil in accordance to the WHO standards can improve the ecosystem as well as public health.
Health knowledge and livelihood experiences with COVID-19 amongst Arizona residents
Authors: Fingesi Tina , Chung Yon Lin , Soto Sheila , Rosales Cecilia
Published: October 2022

The Coronavirus disease 2019 (COVID-19) pandemic is an ongoing public health concern that is rapidly evolving and has impacted individuals and communities differently. We analyzed deidentified survey datasets to evaluate the perceptions, experiences, and impacts of COVID-19 among Arizona residents. The survey included 1,472 eligible Spanish-speaking participants in Southern (Pima, Santa Cruz, Cochise, Yuma County) and Central Arizona (Maricopa County). Eighteen questions which included participants' health and socio-economic status, source of information on COVID-19, preventive measures, the impact of COVID-19 on household income, and vaccination status were administered to the survey respondents. The analyzed data showed an unequal proportion of the reported source of COVID-19 information between Southern and Central Arizona participants. More male respondents (n = 833, 57%) participated in the study than did the female respondents (n = 638, 43%). Of the 1,472 total participants in both regions, 1,011 (68.7%) participants represented Southern Arizona while 461 (31.3%) participants represented Central Arizona. Of the 461 participants in Central Arizona, the majority reported television (56%) and social media (20%) as their primary source of information. Whereas, of the 1,011 participants in Southern Arizona, the majority reported social media (37%) and television (32%) as their major source of information on COVID-19. Overall, 82% of the participants were vaccinated, with a statistically significant difference between the proportion of vaccinated individuals in the Southern and Central Arizona (chi-square p-value of 0.00139). More individuals in Southern Arizona participated in the survey than in Central Arizona across both genders, with 58% of women reporting loss of jobs due to COVID-19. This study demonstrated that the COVID-19 pandemic profoundly had a more socio-economic impact on women than men, particularly Hispanic women in this subset.
Patient attitude and determinants toward chronic diseases control: A cross-sectional survey in rural China
Authors: Lu Yuanyuan , Zhao Yuhang , Shangguan Xiaofang , Lv Benyan , Huang Rui
Published: October 2022

Objectives

The patients' attitude is critical in disease control. This study aims to explore the determinants of patients' attitude and satisfaction.

Methods

A total of 844 patients in the rural areas of Shandong, Henan, and Sichuan provinces with hypertension or diabetes were randomly selected for investigation. The outcome variables were the patients' attitude and satisfaction toward chronic disease control, which were measured through patient self-reported. Binary logistic regression models were used to explore the determinants of patients' attitude and satisfaction.

Results

Teachers were more likely to regard that chronic disease management was helpful in their chronic disease control than that in farmers (OR = 3.994, 95% confidence interval (CI) = 1.309–12.188). Moreover, the probability of health institutions recording chronic diseases changes and guiding rehabilitation for patients regularly is considered helpful 2.688 times more than those that are not. In addition, receiving chronic disease management services can make patients repute that chronic disease management services are helpful in controlling chronic diseases more capably (OR = 1.582, 95% CI = 2.198–10.771). In terms of satisfaction, patients who do not know regular follow-up tend to be dissatisfied with chronic diseases control result (OR = 0.376, 95% CI = 0.192–0.737; OR = 0.592, 95%CI = 0.417–0.841).

Conclusion

The government increases the promotion of chronic disease management in rural areas to improve patients' awareness. Health institutions also can provide diversified services to meet the needs of more people. At last, paying more attention to the timeliness of health services need to be considered to develop a health plan.