bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of CD209 as an Intervention Target for Type 2 Diabetes after COVID-19 Infection: Insights from Proteome-wide Mendelian Randomization
Authors: Zhang Jiaying , Jiao Feng , Wang Zhenqian , Zou Chenfeng , Du Xiangjun , Ye Dewei , Jiang Guozhi
Published: January 2025

Increasing evidence suggests that individuals infected with Coronavirus disease 2019 (COVID-19) are at a higher risk of developing type 2 diabetes (T2D) compared to those who are not infected. However, the mechanisms underlying this relationship remain poorly understood. In this study, we aimed to systematically evaluate the mediating roles of 3,283 plasma proteins in the link between COVID-19 susceptibility and T2D by conducting proteome-wide Mendelian randomization (MR) analyses. Reverse MR, validation in independent datasets, and colocalization analyses were conducted to verify the robustness of the MR results. Furthermore, mediation analysis was carried out to quantify the mediating effects. MR analyses between protein and T2D-related phenotypes were conducted to enhance the comprehension of potential mechanisms. Finally, the druggability of the identified proteins was evaluated. Four proteins causally associated with susceptibility to COVID-19 (ABO, CD209, CUZD1, and QXOS2) exhibited significant causal links with T2D. The protein CD209, which exhibited significant associations in validation and colocalization analyses, was identified as the causal mediating protein. Mediation analysis indicated that CD209 significantly mediated the total effect from COVID-19 susceptibility to T2D (βindirect[95%CI]: 0.083[0.014-0.152], P=0.019). Further MR analyses revealed significant associations between CD209 and hemoglobin A1c, fasting glucose, fasting insulin, and waist-to-hip ratio. Evaluation of druggability demonstrated that CD209 can bind to Alpha-D-mannose and interact with 9 targets of T2D drugs including dipeptidyl peptidase 4 (DPP4). Our findings propose CD209 as a potential intervention target in individuals infected with COVID-19 to prevent T2D, providing novel insights into the pathophysiology linking COVID-19 and T2D.
Contribution of Pharmacy Staff in Cotonou Pharmacies to the Management of Sexually Transmitted Infections with Urethral and/or Vaginal Discharge
Authors: Akpadjan Fabrice , Ali Hissein , Ntouala Nadia , Dotsop Laura , Omono Blandine , Adegbidi Hugues
Published: January 2025

Introduction: Sexually transmitted infections (STIs) remain a major public health issue worldwide. Some patients turn first
to pharmacy staff for medicines. This study aims to assess the knowledge, attitudes and practices of pharmacy staff in Cotonou
regarding STIs with urethral and/or vaginal discharge.
Materials and Methods: This was a cross-sectional study with descriptive and analytical aims carried out on an exhaustive
sample of pharmacy staff working in the pharmacies of Cotonou involved in the dispensing of medications. The data were
collected and analysed using STATA version 15 software.
Results: A total of 94 pharmacies with 732 people were included in the study. The average age of the respondents was 27.9
years. Females were the most represented (sex ratio = 0.4). Pharmacy assistants were the majority (81%). The average
knowledge score was 11 ± 3.1, the average attitude score was 3.1± 1.4 and the average practice score was 6.8± 1.4. The overall
knowledge- attitude- practice (KAP) level of pharmacy staff was average at 50.7%. Low KAP level was significantly associated
with age, professional qualification, prior training or internships on STIs, and having received STI cases at the counter.
Conclusion: The overall KAP score of pharmacy staff on STIs with urethral and/or vaginal discharge is average. This score is
influenced by certain factors that need to be taken into account for the well-being of the population.
Multiple Proliferating Trichilemmal Cysts with Clinical and Microscopic Correlation
Authors: OEL Jouari , MJE Haddad , S Gallouj
Published: January 2025

Proliferating Trichilemmal Cyst (PTC), also known as pilar cyst, is an uncommon benign intradermal or subcutaneous cystic
lesion. It occurs in 5–10% of the population, most commonly on the scalp of elderly women. We present the case of an elderly
Moroccan woman with multiple rapidly enlarging proliferating trichilemmal cysts on her scalp, which were surgically excised.
Histological analysis revealed localized cystic lesions with trichilemmal keratinization and no signs of malignancy. PTC
originates from the isthmic region of hair follicles. It’s typically presents as a slow-growing, subcutaneous cystic nodule that
has been present for several years, often following a history of trauma or chronic inflammation. Although several case reports
have been published in the literature, those involving multiple PTCs with rapid expansion and progression are rare. Differential
diagnoses included epidermoid cysts, pilomatrocomas and squamous cell carcinoma and basal cell carcinoma. PTCs are a rare
histopathological entity, as their histological characteristics may not always align with their clinical behavior. A thorough
histological examination is crucial to identify any focal areas of malignant transformation. Complete surgical excision with a
margin of 1.0 cm to reduce recurrence, is the standard treatment. This case highlights the importance of regular follow-up to
monitor for recurrence or rare malignant transformation, as clinical behavior may not align with histological findings.
Contribution of Precorneal Tear Film to the Total Refraction of the Eye
Authors:   Chita State Medical Academy, Taskina Elizaveta S. , Solovyova Alina A. ,   Chita State Medical Academy, Mudrov Viktor A. ,   Chita State Medical Academy, Makarchuk Nataliya A. ,   Chita State Medical Academy
Published: January 2025

INTRODUCTION: Due to the active use of electronic gadgets and computerization of many areas of life, the problem of computer vision syndrome is becoming more important. Disruption of the stability of the tear film leads to the development of a complex of subjective complaints and objective signs of xerosis of the anterior eye segment associated with impairment of visual functions.
AIM: To analyze the dynamics of the total refraction of eye against the background stabilization of the precorneal tear film in young individuals.
MATERIALS ANF METHODS: The study included 50 individuals aged 24.0 [22.0; 27.0] years. All the patients included in the study, had two scheduled visits with an interval of 35 [30; 41] days, underwent survey-questionnaire, a test for evaluation of the degree of ‘dry eye’ syndrome (Ocular Surface Disease Index), and ophthalmologic examination. The treatment was prescribed in the form of vision hygiene, instillation of rewetting eye drops 3 times a day to stabilize the tear film. Three study groups were formed: a control group and a clinical group including the first group — patients with a mild or moderate ‘dry eye’ syndrome, and the second group — patients with a severe ‘dry eye’ syndrome.
RESULTS: At the follow-up visit after treatment, the difference in the tear film break up time in the control group was 2.0 [1.4; 2.4] sec, in the first clinical grop — 3.0 [2.7; 3.5] seconds, in the second clinical group — 3.0 [2.5; 3.5]. With treatment, myopia in the control group decreased 1.37 [1.13; 1.17] times, in the first group — 1.4 [1.09; 1.08] times, in the second group — 1.25 [1.06; 1.12] times. It was revealed that after treatment, in 42% (21/50) of patients the visual acuitywith maximal correction improved by 1 or more lines.
CONCLUSION: Disorder in the stability of the precorneal tear film contributes to the total refraction of the eye and manifests in impairment of the visual acuity with the development of false myopia. It is important that stability of the tear film be taken into account when selecting optical correction.
Anatomic Variants and Features of Atherosclerotic Lesion of Coronary Artery Bifurcations
Authors:   Ryazan State Medical University, Kalinin Roman E. , Suchkov Igor’ A. ,   Ryazan State Medical University, Karpov Aleksandr V. ,   Ryazan State Medical University,   Clinical Hospital No. 6 named after G. A. Zakharin, Shanayev Ivan N. ,   Ryazan State Medical University
Published: January 2025

INTRODUCTION: Atherosclerotic lesion of coronary arteries is the ultimate cause of the development of the coronary heart disease. The situation becomes more complicated with the involvement of bifurcations of the coronary arteries, since their endovascular correction presents a problem which has not been completely solved until the present moment.
AIM: To clarify the anatomic variants of coronary artery bifurcations and features of their lesion in atherosclerosis.
MATERIALS AND METHODS: The study included 342 patients with an acute coronary syndrome, 85 of them had bifurcation stenoses of coronary arteries and subsequently underwent endovascular correction of these lesions. The study was conducted in Clinical Hospital No. 6 named after G. A. Zakharin of Penza from August of 2021 to December 2022. In 5 patients (5.9%), the main artery gave off two side branches in the zone of lesion, thus 90 bifurcations were included in the study.
RESULTS: The proportion of bifurcation stenting made 26.3% of the total stenting operations. Bifurcation lesions more often occurred in the system of the left coronary artery (87.8%) in comparison to the right one (12.2%). The most common disorder in the left coronary artery system was lesion of the anterior descending artery and of the diagonal branch (57.8%). In 78.9% of cases, the angulation of the side branches in bifurcation lesions was less than 70°, in 18.9% – more than 70° and in 2.2% more than 90°. The composition of bifurcation lesions according to Medina classification was 1-1-1 — 26.7%, 1-1-0 — 35.6%, 1-0-1 — 5.5%, 0-1-1 — 4.4%, 0-1-0 — 10%, 0-0-1 — 7.8%, 1-0-0 — 10%.
CONCLUSIONS: The most common location of bifurcation lesions of the coronary arteries is the anterior descending artery in the zone of separation of the diagonal branch. Y-type bifurcation occurs in 78.9% of cases, T-type — in 18%, bifurcations with reverse angulation — in 2.2%. The most common type of bifurcation lesion is 1-1-0 type in Medina classification. The type of coronary bifurcation affects neither the diameter of the lateral branches nor the extent of the atherosclerotic lesion.
Content foundations of future visual arts specialists training in higher education institutions of the USA
Authors: Boichenko Maryna Anatoliivna , Nechyporenko Anna Vitaliivna
Published: January 2025

The article clarifies content foundations of future visual arts specialists’ professional training in higher education institutions in the USA. The historical foundations of future visual arts specialists’ professional training in higher education institutions in the USA were revealed. It is found that the history of art education development in the USA dates back to the late 18th century, and began with individual art subjects in urban schools, and then developed and modernized thanks to new concepts in the field of art. Within the regulatory framework, the provisions of a number of laws are characterized, in particular, the “Higher Education Act”, which regulates general provisions for higher education institutions functioning in the USA, and are based on the principles of freedom of expression and artistic activity; development of creative and critical thinking; promoting free and open exchange of ideas; students should be treated equally and fairly; the diversity and breadth of artistic theories and methods; taking into account the opinions of students in all aspects of university life; equality of opportunities (social, gender, etc.) and so on. The content of future visual arts specialists’ training in higher education institutions in the USA was highlighted on the example of the educational program provided by the Taylor School of Art and Architecture, Temple University in the specialty “Graphic Design”, specialization “Illustration and New Media”. It is determined that the purpose of training students in higher art education institutions in the USA is to increase their professional competence in the field of visual arts and provide them with appropriate consultations. The selection of methods for teaching graphic design in accordance with the main type of activity, as well as development of professional and general theoretical skills, which correspond to the individual creative abilities of students, are also aimed at improving their professional experience.
Стратегія оновлення концертного репертуару народних хорових колективів у ХХІ столітті
Authors: Ладний Антон Сергійович
Published: January 2025

У статті охарактеризовано сучасні репертуарні тренди українських народних хорових колективів, які відображають як багатовікову спадщину, так і вплив сучасних культурних процесів. Особливу увагу приділено вивченню викликів, з якими стикаються композитори та хормейстери у створенні інноваційних музичних аранжувань. Основним завданням у цьому контексті є досягнення балансу між збереженням автентичності фольклору, який є цінним джерелом національної ідентичності, та впровадженням сучасних художніх рішень, що дають можливість осучаснити репертуар. Встановлено роль новітніх технологій у розвитку народно-хорового мистецтва. Вони не лише розширюють можливості аранжування, зокрема завдяки використанню цифрових звукових інструментів, а й сприяють популяризації фольклору через сучасні медіа та платформи. Окреслено значення інноваційних обробок народних пісень у формуванні культурної свідомості та національної ідентичності, що є особливо актуальним у контексті глобалізації та зміни музичних уподобань молодого покоління. З’ясовано, що якісне аранжування є визначальним фактором у формуванні актуального концертного репертуару народних хорових колективів. Визначено основні підходи композиторів та аранжувальників до адаптації народних мелодій відповідно до сучасних виконавських вимог. Зазначено, що сучасні підходи сприяють не лише збагаченню звучання завдяки новим тембровим і стильовим рішенням, але й збереженню художньо-образного змісту, який є основою автентичного сприйняття фольклорних творів. Проаналізовано низку обробок українських народних пісень, створених видатними композиторами минулого, зокрема Миколою Леонтовичем, і сучасними аранжувальниками, які продовжують традицію художнього осмислення фольклору. Розглянуто також адаптації академічних і естрадних творів для народних хорів, що свідчить про широту репертуарних рішень. Особливу увагу приділено взаємодії традиційного та сучасного в репертуарі народних хорових колективів, адже це дає змогу зберігати національну ідентичність, водночас відповідаючи викликам культурної динаміки XXI століття. Такі твори сприяють формуванню глибокого емоційного зв’язку з публікою, зокрема серед молоді, популяризуючи українську пісенну спадщину не лише в Україні, а й за її межами. Встановлено, що хорові обробки українських народних пісень XXI століття активно зміцнюють позиції українського хорового мистецтва на світовій сцені. Вони відкривають нові можливості для творчих експериментів, що поєднують традиційність із сучасністю, створюючи багатогранний і водночас доступний репертуар.
Принципи розвитку художньо-естетичних уявлень студентів на заняттях сольним співом
Authors: Петрикова Оксана Петрівна , Леонтієва Софія Леонідівна , Гузь Анастасія Валеріївна
Published: January 2025

У статті розкрито проблему розвитку художньо-естетичних уявлень майбутнього співака як основи його професіоналізму. Авторами опрацьовано та проаналізовано науково-методичну літературу, що висвітлює сутність художньо-естетичних уявлень, її специфіку і складові, а також основні принципи формування означеного феномена в майбутніх співаків на заняттях сольним співом. З’ясовано, що вокально- виконавська підготовка має потужний потенціал щодо загального художньо-естетичного розвитку студента-вокаліста, зокрема для розвитку художньо-естетичних уявлень майбутнього співака, оскільки вона містить значний перелік різновиді роботи, що сприяють накопиченню художньо-естетичного досвіду, набуттю необхідних ціннісних орієнтирів, необхідних для формування вірних художньо-естетичних смаків та ідеалів. Авторами окреслено сутнісні характеристики уявлень як психічного утворення, надано їх класифікацію та визначено функції. У науковій розвідці щодо основного поняття дослідження розглянуто проблему розмежування естетичного та художнього, з’ясовано сутність естетичних уявлень і художніх уявлень, визначено відмінні риси означених феноменів. Автори під художньо-естетичним уявленнями майбутнього співака розуміють складний комплекс слухо-зорово-моторних образів, утворених за результатами набуття студентом пізнавального й емоційно-чуттєвого досвіду в процесі вокально-виконавської діяльності. Наголошено на вагомості широти мистецького кругозору та мистецької ерудованості як показниках розвиненості художньо-естетичних уявлень студента-вокаліста. Сформульовано принципи розвитку художньо-естетичних уявлень студента-вокаліста, серед яких створення у студентів-вокалістів позитивної установки щодо «спілкування» з творами мистецтва; стимулювання особистісного оцінного ставлення студентів до найкращих зразків мистецтва та сприяння розширенню мистецького кругозору майбутніх співаків під час вокальної роботи над творами індивідуальної програми. Теоретично обґрунтовано впровадження в навчальний процес кожного із запропонованих принципів. Наголошено на необхідності діалогічних засад, атмосфери довіри та дружності та забезпеченні емпатійності навчання на заняттях сольним співом.
Primary art education as an organizational condition for the formation of students’ musical culture
Authors: Rebrova Olena Yevhenivna
Published: January 2025

The purpose of the article is to highlight the specifics of education in art schools as an organizational condition for the formation of students’ musical culture. To achieve the goal, the analysis of scientific sources, comparison of various pedagogical approaches and practical experience in the context of specialized art education was used. Musical culture is considered as an integration of theoretical knowledge, practical skills, emotional and aesthetic experience and creative abilities, which contributes to the formation of a harmoniously developed personality. The author emphasizes the importance of developing a culture of listening to music, which is a primary stage in the process of forming musical competences, which become the basis of the highest level – the musical culture of art schools’ students. In addition, the author considers the role of musical literacy, which includes not only performance skills and abilities, but also students’ ability to emotionally perceive music and critically evaluate it. Special emphasis is placed on artistic awareness, emotional sensitivity, and creative development as components of musical culture. The author addresses the importance of aesthetic assessment as the final stage of aesthetic perception, which is based on the emotional and value-oriented understanding of music and is an important component of the student’s cultural development. It is also claimed that modern teaching methods, in particular interactive and innovative ones, contribute to the development of students’ musical competences, in particular by stimulating auditory imagination and emotional reactions. An important aspect is the integration of performing abilities and skills with emotional and aesthetic perception. It was determined that specialized art educational institutions are important institutions for the formation of students’ musical culture. They provide a systematic and consistent approach to learning that takes into account the individual characteristics of students, their interests, motivation and abilities. The musical competences acquired in these institutions are the basis for the further development of students as creative individuals and contribute to their emotional-aesthetic, cultural and social development.
Aesthetic Experience and Creativity of Expert Cultural Entrepreneurs in Colombia: A Qualitative Study
Authors: Monroy Ernesto , Gutierrez-Gonzalez Lisseth , Barrios Diana
Published: January 2025

This qualitative research addresses the psychological study of the confluence between aesthetic experience and creative process in cultural entrepreneurs, taking into account that research in Psychology of Aesthetics and Psychology of Creativity is necessary to achieve a better understanding of innovation in creative industries. We conducted a qualitative study on the role of aesthetic experience in the creative process, through in-depth, semi-structured interviews with 12 expert cultural entrepreneurs from the Colombian Caribbean. As a result of a thematic analysis, we found that aesthetic experience is a relevant guide in the creativity of cultural entrepreneurs, usually represented in receptivity to aesthetic sensations that emerge during the creative process. Also, in the midst of the creative process, the entrepreneurs try to maintain a balance between individual and collective needs.
Derechos humanos al agua y al saneamiento en dos localidades rurales del estado de Puebla
Authors:   Instituto Mexicano de Tecnología del Agua, Soares Denise
Published: January 2025

El agua, además de constituirse en servicio básico esencial que satisface las necesidades humanas, es un derecho humano consagrado en instrumentos internacionales. A pesar de que el derecho humano al agua esté plasmado en la constitución mexicana desde 2012, la problemática de acceso al agua en zonas rurales y periurbanas marginadas sigue siendo una asignatura pendiente.
Memories of Elderly People About the Discovery Of HIV/AIDS Contagion
Authors: Oliveira Alessandra Souza de , Reis Luana Araújo dos , Nery Shahjahan Mozart Alexandre da Silva , Mascarenhas Félix Meira , Souza Joana Trengrouse Laignier De , Reis Luciana Araújo dos
Published: January 2025

Objective: To analyze the memories of elderly people about the discovery of HIV/AIDS infection.
 
Theoretical framework: The diagnosis of HIV/AIDS in the elderly population has been a reality, in light of numerous studies that reveal this phenomenon in this age group. The repercussions completely change the daily life of elderly people in relation to aspects related to their physical, mental, emotional and social health.
 
Methods: A questionnaire with sociodemographic data and health conditions was applied, as well as a script for a semi-structured interview with questions about the diagnosis and living with HIV/AIDS.
 
Results and discussion: The memories of elderly people about the discovery of HIV/AIDS infection reveal the recovery of faith and religiosity as a strategy for coping with the diagnosis and the ambivalent feelings regarding living with drug treatment, between the memory of stabilization of the disease and the representation of the burden, risk of exposure of confidentiality about the diagnosis and suffering due to symptoms caused by adverse reactions.
 
Research Implications: The practical and theoretical implications of this research are discussed, providing insights on how the results can be applied or influence practices in the field of aging in the unified health system.
 
Originality/Value: This study contributes to the literature by addressing the experiences of elderly people with HIV/AIDS, demonstrating the need for collective commitment from public and private institutions and the involvement of the entire society, in a set of actions to confront prejudice and stigmatization.
Influence of Different Uses and Covers on the Chemical Characteristics of A Quartzarenic Neosol in the Maranhão Savannah
Authors: Silva Wilson Araújo da , Silva Cristiane Matos da , Viana Jonathan dos Santos , Silva Alinne da , Fernades Elizabeth Nunes
Published: January 2025

Objective: This study evaluated the effect of three different land uses and soil covers on the chemical characteristics of a QUARTZARENIC NEOSSOLO in the Maranhão Cerrado. The treatments studied were: conventional pasture (PC), open area (AD) and typical cerrado (CT).
 
Theoretical Reference: The study is based on concepts of soil fertility, especially the impact of agricultural management practices, such as liming and fertilisation, on the chemical composition of the soil. The QUARTZARENIC NEOSSOLS, due to their sandy texture and low nutrient and water retention capacity, present limitations for agricultural cultivation, according to studies by Embrapa  (2021).
 
Method: Macronutrients (P, S, Ca and Mg), micronutrients (Zn, Mn, Fe and Cu), organic matter (OM) content and base saturation (V%) were analysed. Samples were collected according to the protocol suggested by Embrapa (2015) and were taken from three representative areas of the treatments mentioned. The data was analysed using statistical tests of variance (ANOVA) and paired mean tests (Tukey).
 
Results and Discussion: The results showed that, for most of the chemical parameters analysed, the highest averages were obtained in the conventional pasture area (CP). This is due to the chemical residues from liming and fertilisation applied when the pasture was established and managed. On the other hand, the uncovered area (AD) and the typical cerrado (CT) showed lower concentrations of nutrients and organic matter. The analysis also revealed that the QUARTZARENIC NEOSSOLS in this region, despite their natural limitations, can be productive when well managed.
 
Research Implications: The research highlights the importance of proper soil management, especially liming and fertilisation, to improve fertility and make agricultural production viable on QUARTZARENIC NEOSSOLS. Conventional grazing can be an effective strategy for improving the soil's chemical conditions, although it is also necessary to properly manage bare areas to avoid soil degradation.
 
Originality/Value: This study contributes to the understanding of the effects of different land uses on the chemical properties of QUARTZ NEOSSOLS in the Maranhão Cerrado. The research offers insights into how to improve agricultural productivity and the sustainability of management in areas with natural limitations, highlighting the potential of areas apparently unsuitable for cultivation.
The Antecedents of Perceived Value in Cargo Tires Retreading
Authors: Santos Mateus Silva , Falcão Roberto Flores , Santos Francisco Carlos Barbosa Dos
Published: January 2025

Objective: Due to increasingly low freight prices and increasingly high operating costs, tire retreading presents itself as a viable and safe solution for costs reduction. It presents itself as a more sustainable alternative in terms of tire consumption. This paper discusses the consumption behavior of small fleet owners in relation to the purchase of cargo tire retreading services.
 
Theoretical Framework: Our theoretical framework is organized into two axes: how tires and their retreading are carried out in Brazil considering small entrepreneurs, and how the multidimensionality of consumer behavior affects the relationship with the tire retreading service (based on the SERV-PERVAL proposal developed by Petrick (2002) and the “Affective Behavior” dimension of the model developed by Roberts, Varki and Brodie (2003), called Relationship Quality).
 
Method: A model on the antecedents of the perception of value was proposed and refined (the questionnaire items were reorganized through exploratory and confirmatory factor analysis) based on a survey of 109 truck drivers.
 
Results and Discussion: The antecedents of the perception of value of small fleet owners in relation to the cargo tire retreading service are the Sentimental constructs; Reputation; Loyalty; Convenience; Cost/Benefit.
 
Originality/Value: Previous studies focused on the field of production engineering, use, performance and impacts on the environment, new tire purchasing behavior, association studies or government, not presenting in the literature studies in marketing or even business administration and its derived areas for tire retreading services.
 
Research Implications: This study helps small tire retreaders to better understand their customers and enables better customer service that culminates in increased market share and profitability.
Genetic Profile of Bacteria in Marketed Foods: A Literature Review
Authors: Cruz Amanda Alany Ferreira Lopes , Lima Anderson Pereira de , Sampaio Milena Alves de Lima , Santos Marcos Aurélio Figueirêdo dos , Nascimento Lariza Leisla Leandro , Antunes Dhenes Ferreira , Ulisses Valdilia Ribeiro de Alencar , Alencar Xênia Germana Rodovalho de , Silva Nathallia Correia da , Freitas Damiana Gonçalves de Sousa , Souza Dieferson Leandro de , Luz Germana de Alencar Maia , Sousa Severino Denicio Gonçalves de , Almeida-Bezerra José Weverton , Freitas Priscilla Ramos
Published: January 2025

Objective: The purpose of this study is to carry out an exploratory literature review on the profile of bacterial resistance genes in samples of commercialized foods.
 
Theoretical Framework: Around 90% of foodborne illnesses are caused by bacteria and despite the improvements recorded in combating of contaminations, they continue to be a public health challenge, mainly due to the increased of bacterial resistance.
 
Method: An analysis of articles was carried out in the national and international databases PubMED and SCIELO, in the period between 2020 and 2024 in Portuguese, English and Spanish, resulting in 81 articles related.
 
Results and Discussion: The Microbiology reveals information about hygiene conditions during food preparation processes, with its techniques for isolating and identifying bacteria. Genetic tests contribute to quality control by evaluating the profile of resistance genes, performing DNA extraction with subsequent analysis of the integrity of the material obtained by the electrophoresis and the identification of resistance genes.
 
Research Implications: The development of research that seeks indicators that reveal the potential for contamination in a given food is essential for better control of microbiological quality in the food sector, in order to guarantee food safety.
 
Originality/Value: This research aims to contribute to the community and the scientific community with information about the importance of hygiene practices in food preparation, adequate washing of hands and utensils used in preparation, promoting the importance of microbiology and molecular genetics as agents active and necessary in quality control in conjunction with the actions established by Anvisa.
Percepção de médicos sobre a relação entre estresse e doenças psicossomáticas em pacientes pediátricos e adultos
Authors: Siqueira de Moraes Mesquita Vitor , De Alcantara Moreira Emanuelle , Alves Alberice Benedicto Carvalho Jéssica , Moreira Correa João Pedro , Tenório Pedro Maia Letícia , Nunes Ferreira Patrícia , Henrique Delgado Maia Pedro , De Paula Campos da Silva Richardson
Published: January 2025

Introdução: O estresse compreende um conjunto de reações e estímulos que causam distúrbios no equilíbrio do organismo frequentemente com efeitos danosos e podem provocar várias doenças psicossomáticas que surgem como consequência de processos psicológicos e mentais do indivíduo desajustados das funções somáticas e viscerais e vice-versa. Objetivo: O objetivo deste trabalho foi identificar a relação entre estresse e doenças psicossomáticas conforme a percepção de médicos e compreender como os sinais e sintomas se manifestam em pacientes pediátricos e adultos. Materiais e métodos: Trata-se de um estudo descritivo, de desenho transversal, quantitativo e qualitativo. Utilizou-se um “Questionário sociodemográfico e profissional”, seguido de uma Entrevista semiestruturada, para coleta de dados a fim de gerar as análises qualitativas e quantitativas. Resultados e discussão: A pesquisa contou com a participação de dois médicos especialistas de cada área: Geriatria, Pediatria, Dermatologia, Reumatologia, Gastroenterologia e Coloproctologia. A maioria era do sexo masculino (58%) e tinha entre 36 e 46 anos de idade (58%). Em relação ao tempo de formado, 42% tinham entre 21 e 30 anos e 58% havia cursado a pós-graduação na modalidade de especialização. As entrevistas deram origem a sete categorias temáticas: “Estresse e doenças psicossomáticas”, “Processo do diagnóstico”, “Características fisiológicas”, “Aspectos psicológicos relacionados ao estresse”, “Impactos da pandemia de Covid 19”, “Possibilidades de tratamento” e “Redes de apoio no tratamento”. Conclusão: Os resultados evidenciaram que a maior parte dos entrevistados encaminha os pacientes com doenças psicossomáticas para acompanhamento com profissionais da área de saúde mental, como psiquiatras e psicólogos, e indicam o uso de terapias alternativas, prática de atividades físicas e importância da rede de apoio familiar no tratamento.
Extrarenal monoclonal immunoglobulin deposition disease: mechanisms, clinical presentation, diagnostics and treatment approaches (review)
Authors: Khrabrova M. S.
Published: January 2025

In monoclonal gammopathies the aberrant B-cell clone produces the monoclonal immunoglobulin (MIG) which could present as only one light chain or only one heavy chain or the whole immunoglobulin. Due to somatic mutations in B-cell clone genetic the MIG obtains abnormal features and different types of tissue toxicity. The condition of non-organized granular MIG deposition leading to organ damage and dysfunction is known as monoclonal immunoglobulin deposition disease (MIDD). Most commonly MIDD involves the kidney parenchyma. However, extrarenal MIDD may affect other tissues and present as local or systemic condition. This review summarizes the current knowledge concerning the mechanisms, clinical manifestation, diagnostics and treatment approaches in extrarenal MIDD.
Issues in diagnosis of pulmonary hypertension
Authors: Churko A. A. , Nikonova A. I. , Halilova L. A. , Panina I. Yu. , Kulikov A. N.
Published: January 2025

Pulmonary hypertension (PH) – is a pathophysiological condition, which characterized by pressure elevation in pulmonary vascular bed without regard to its causes. Despite the great progress in understanding of etiology, pathophysiology and molecular mechanisms of PH, clinical diagnosis is still a great challenge for the medical practitioner. Lack of specific symptoms, demand of wide range of knowledge, necessity of well-equipped hospital – all these reasons lead to late diagnosis and treatment. In this article we provide brief information of clinical evaluation in case of PH and transthoracic echocardiography as a first step of instrumental examination towards precise diagnosis. .
The Universal force of Ageity d (or Universal Force of Temporality t) and Everyday Examples of Entropy or Disorder in which it Manifests Itself
Authors:   Centro De Prevención Y Tratamiento De La Violencia Sexual E Intrafamiliar, Cuevas-Sosa Alejandro
Published: January 2025

Almost always the prefix bio- refers to bioenergeme, like biospecies or species with BEG; or to bioenergemal, like bioenergy or bioenergemal energy
La consolidación del campo del arte en Colombia: influencias y transformaciones en el siglo XX
Authors: Fernández Gómez Sara
Published: January 2025

This study explores how factors such as the emergence of cultural publications, the professionalization of criticism, the rise of museums and galleries, among others, shaped the narrative of Colombian art history in the second half of the twentieth century, emphasizing the interconnection of artists, artworks, critics, and the public within the evolving artistic landscape. Through a metahistorical lens, it considers the concept of the nation as a site of enunciation, highlighting the complex interaction between art, context, and national identity. By examining the multifaceted perspectives presented in texts from this period, this research underscores the importance of avoiding reductionist approaches in the study of art history.
El placer del paisaje. Pintura y poesía en Colombia, 1840-1940. Curaduría de Juan Darío Restrepo y César Mackenzie
Authors: Reinach Baumgartner Christian
Published: January 2025

Review. El placer del paisaje. Pintura y poesía en Colombia, 1840-1940. Curaduría de Juan Darío Restrepo y César Mackenzie.
Juliet B. Wiersema, The History of a Periphery: Spanish Colonial Cartography from Colombia’s Pacific Lowlands. University of Texas Press, 2023. 256 pp.
Authors: Fernández-Salvador Carmen
Published: January 2025

Review. Juliet B. Wiersema, The History of a Periphery: Spanish Colonial Cartography from Colombia’s Pacific Lowlands. University of Texas Press, 2023. 256 pp.
Computed tomography and magnetic resonance imaging features of abdominal and pelvic leiomyomatosis peritonealis disseminata: A retrospective observational study
Authors: He Xin , Ma Xinxing , Jiang Nan , Weng Chunjiao , Yang Ling
Published: January 2025

Objectives:

Leiomyomatosis peritonealis disseminata (LPD) is a rare and specific type of leiomyomatosis that is often misdiagnosed as malignant tumor with peritoneal metastasis, and accurate diagnosis is critical to treatment planning. The purpose of this study is to investigate the radiological features of LPD, analyze, and summarize its differential diagnosis and clinical features to improve the understanding of this rare disease.

Material and Methods:

A retrospective analysis was conducted on clinical and radiological features from 10 patients with pathologically confirmed LPD between 2012 and 2024. The computed tomography (CT) and magnetic resonance imaging (MRI) findings were examined, focusing on parameters such as location, morphology, size, quantity, enhancement patterns, and their relationship with adjacent organs. In addition, the radiological features and the key points of differential diagnosis were summarized.

Results:

All the 10 LPD patients presented with multifocal lesions in the abdomen and pelvis, and 7 of them had a history of hysteromyoma surgery. The number of lesions was all ≥2, most of them were round or quasi-circular, with clear boundaries and smooth edges, did not invade the neighboring parenchymal organs, with a length of about 1.5~16.8 cm. The lesions were located in the pelvic cavity in 6 cases, the abdominal wall in 6 cases, the intestinal wall in 3 cases, the rectouterine pouch in 1 case, the omentum in 5 cases, the abdominal cavity in 1 case, and the mesentery in 1 case. There were 7 cases with minimal pelvic fluid and 1 case with liver spread. CT showed circular solid nodules with clear boundaries. The density of small lesions was homogeneous. Cystic changes were observed in some large lesions. On MRI, T1-weighted imaging showed hypo to isointense, T2-weighted imaging (T2WI) mostly showed hypointense, and T2WI in some large lesions showed slightly high signal intensity, diffusion-weighted imaging signal intensity was not higher than that of myometrium, apparent diffusion coefficient showed isointense, and solid components of the lesions were significantly more homogeneous enhanced after enhancement, and the enhancement degree was similar to that of normal myometrium.

Conclusion:

Although the imaging findings of LPD are similar to malignant tumors with peritoneal implantation and metastasis, they have certain characteristics, which are helpful for differential diagnosis combined with the clinical history of patients.
On the practical application of Russian-made dismantling robotic complexes addressing the challenges in the decommissioning of radiation hazardous facilities
Authors:   Nuclear Safety Institute of the Russian Academy of Sciences, Kalenova M. Yu. , Kuznetsov I. V. ,   Nuclear Safety Institute of the Russian Academy of Sciences, Ivanov A. Yu. ,   Nuclear Safety Institute of the Russian Academy of Sciences, Perov A. V. ,   Nuclear Safety Institute of the Russian Academy of Sciences, Ilyina O. A. ,   Nuclear Safety Institute of the Russian Academy of Sciences
Published: January 2025

The article evaluates the current use of robotic systems (RS) in the decommissioning of a legacy radiation hazardous facility and specifies the aspects restricting their large-scale implementation. The article describes the tests of the ROIN RTS R-100 and Betonolom-2000 dismantling systems manufactured in the Russian Federation at the Moscow branch of FSUE RADON that confirmed the operability of the equipment and the high potential for its further implementation given proper adaptation to the decommissioning tasks at hand. The paper specifies the technical parameters for various operations and presents the calculated performance indicators for the hydraulic hammer. It provides recommendations on further efforts that are expected to enhance the efficiency of the equipment and were formulated based on the practical results achieved to date. The paper notes that the RS efficiency is influenced by numerous factors with the operator's qualifications and skills being of greatest importance, which should be considered in the decommissioning work planning. It highlights the prerequisites for further RS introduction considering the achieved safety level and lower negative impact of harmful production factors on the personnel.
Natural Radionuclides in the Geological Environment of the Yeniseiskiy Site (the Krasnoyarsk Territory)
Authors:   JSC “Krasnoyarsk Geology”, Ozerskiy A. Yu. , Ozerskiy D. A. ,   Nuclear Safety Institute of the Russian Academy of Sciences
Published: January 2025

The paper explores the abundance of natural radionuclides ( 226Ra, 232Th and 40K) in the main types of host rocks available at the Yeniseiskiy site (Archaean gneisses and dolerites). The study shows that the host rocks do not pose any risks associated with personnel exposure in the underground structures, radiation contamination of the environment and are characterized by low effective specific activities, i.e., the rocks are authorized to be used in all types of construction. The paper considers the abundance of radionuclides characterized by low average concentrations with the exception of 232Th. It demonstrates the differences in the activity and abundance of natural radionuclides between the upper part of the rock massif (to a depth of 150 m) and its deep-seated part, as well as lower concentrations of uranium in the upper part of the massif. It roughly estimates the groundwater potential as regards uranium carry-over from the upper zone.
Conservative long-term nuclear safety assessment of a deep radioactive waste disposal facility
Authors:   Nuclear Safety Institute of the Russian Academy of Sciences, Kizub P. A. , Kulish E. S. ,   Nuclear Safety Institute of the Russian Academy of Sciences, Blokhin P. A. ,   Nuclear Safety Institute of the Russian Academy of Sciences, Kozlov P. V. ,   TSL FSUE “PА “Mayak”
Published: January 2025

The distinctive characteristic of vitrified high-level waste (VHLW) is its high concentration of transuranic elements with long half-lives. This can lead to a potential violation of nuclear safety standards in the long run due to increased concentrations of fissile nuclei that are considered nuclear-hazardous. For three vitrification campaigns of HLW conducted at FSUE "PA "Mayak", the compositions of the HLW were determined long after their expected time of isolation at the disposal site were calculated using the TRACT nuclide kinetics program. Based on these VHLW compositions, conservative models of a well-designed disposal site were created and variant criticality calculations were performed using the TDMCC Monte Carlo program. The calculation results indicate that the system remained nuclear safe in the long-term.
Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human STING Receptor
Authors: Sparks Robert , Lawless William , Kharitonova Anna , Metcalf Rainer , Nunziata Jamie , Binder Grace , Chaudhury Sauradip , Gambino Christine , Wilde Michelle , Harding Linette , Crews Jaret , Gopu Mansi , Dalamangus Emilia , Lawless Sarah , Eschenfelder Mark , Green Robert , Nompleggi Elizabeth , Tran Timothy , Yang Yan , Trask Donna , Thompson Paul , Patel Niketa , Patel Rekha , Brooks Wesley , Bradley Guy , Acevedo-Duncan Mildred , Mullen Alan , Leahy James , Daniel Kenyon , Guida Wayne
Published: January 2025

Stimulator of interferon genes (STING) is a transmembrane endoplasmic reticulum (ER) resident protein involved in innate immunity. STING activation occurs by binding of cyclic guanosine-(2'→5')-monophosphate-adenosine-(3'→5')-monophosphate (2’,3’-cGAMP) to STING, which leads to downstream production of type 1 interferons (IFN-1). We generated molecular dynamics (MD) equilibrated agonist and antagonist models of human STING (hSTING) for computer based screening and now report the discovery of clonixeril (CXL) as the most potent non-nucleotide hSTING modulator discovered to date. We demonstrate in vitro and in cellulo that CXL has two modes of interaction with hSTING, one with an EC50 above 1 nM and the other with an EC50 in the 1 fM - 100 aM range (10-15–10-16 M). In cell based experiments, when CXL is titrated below 1 nM, it displays inverse dose dependent antagonistic behavior toward hSTING. We have substantiated that CXL displays this exceptionally strong inhibitory effect on hSTING mediated IFN 1 production using a THP 1 cell luciferase reporter for interferon regulatory factor 3 (IRF3). Further characterization of CXL was performed in HEK293 cells and by using biophysical and biochemical techniques.
Microenvironment effects from first principles multiscale modeling of electrochemical CO2 reduction
Authors: Lorenzutti Francesca , Seemakurthi Ranga , Johnson Evan , Morandi Santiago , Nikacevic Pavle , Lopez Nuria , Haussener Sophia
Published: January 2025

Electrochemical CO2 reduction will be a key player in net-zero technologies, yet its industrial implementation is limited. Improvements by fine-tuning the microenvironments, electrolyte environments around the catalytic sites, have been scarce due to the interplay between electrode kinetics and transport. Here, we couple atomistic insights with continuum transport via ab-initio multiscale modeling, explicitly including electrolyte effects at all scales. The model was validated on Ag planar electrodes in several liquid electrolytes and the current dependence with voltage aligns with experimental observations. We show that a balance between CO2 diffusion and cation accumulation needs be achieved to obtain optimal rates. In ionomers, this limitation can be overcome since organic cations-based microenvironments are present at a fixed concentration, but water management becomes critical. Our approach paves the way towards rational microenvironment design in electrochemical CO2 conversion.
Site-Selective and Late-Stage Deuteration of (Hetero)arenes with Supported Iridium Nanoparticles
Authors: Yao Chengbo , Copéret Christophe
Published: January 2025

Deuterated compounds have emerged as critical tools across diverse research areas, including pharmaceuticals, where deuterium incorporation can modulate the absorption, distribution, metabolism, and excretion (ADME) properties of drugs. In this study, we report the development of a new hydrogen/deuterium (H/D) exchange catalyst based on support-ed iridium nanoparticles, which enables selective deuteration of arenes and heteroarenes under mild conditions. Using C6D6 as the deuterium source, our catalytic system achieves high chemo- and regioselectivity, avoiding the common side reactions such as hydrogenation and dehalogenation observed with traditional heterogeneous catalysts. Notably, the deuteration occurs selectively at the para- and meta-C(sp2)–H bonds, leaving ortho C(sp2)–H and C(sp3)–H bonds intact, and exhibits broad functional group tolerance, including with ketones, amides, alkenes, aryl ethers, and acidic protons. The heterogeneous nature of the catalyst was confirmed via filtration and mercury drop tests. This work presents a new cata-lytic system for regioselective deuteration of complex molecules, offering complementary site selectivity to existing homogeneous and heterogeneous methods and the possibility to be used in the late-stage deuteration of pharmaceuticals.