bluuebunny/crossref_metadata_2025 huggingface dataset:
The Mechanical Properties of Geopolymers from Different Raw Materials and the Effect of Recycled Gypsum
Authors: Korhonen Henna , Timonen Juha , Suvanto Sari , Hirva Pipsa , Mononen Kirsi , Jääskeläinen Sirpa
Published: July 2023

Geopolymers are amorphous inorganic polymers that are mainly used in the construction industry as an environmentally friendly alternative to ordinary cement. This study compared selected mechanical properties (setting time, shrinkage, strength) of geopolymer specimens made from different main raw materials, mainly at room temperature, and investigated the effects of recycled gypsum on these. A structural analysis of the specimens was conducted with XRD and SEM. Also, the leaching of aluminium, silicon, and calcium from the specimens was investigated. According to this study, raw materials have a significant impact on the properties of geopolymers. Recycled gypsum affected the setting time of the geopolymers, but the effect was not the same for all specimens. It increased the setting time of specimens made from calcium-rich raw materials, for example, and the ground-granulated blast furnace slag specimens hardened as fast as ordinary Portland cement (about 300 min), but the addition of gypsum decreased it to 1300 min. Gypsum-containing specimens, based on Ca-deficient metakaolin or fly ash, hardened even faster than OPC, in 100–150 min. Recycled gypsum significantly reduced the plastic shrinkage of most of the 28 d specimens to lower values than those achieved for OPC (0.07%). The only exceptions were the fly-ash-based specimens. However, gypsum had no effect on the drying shrinkage, which accounted for a larger proportion of the total shrinkage in most specimens. Therefore, it had no significant effect on the total shrinkage of the geopolymer specimens. The reducing effect of gypsum on the plastic shrinkage of geopolymers was attributed to ettringite, which was observed in all gypsum-containing specimens analysed with XRD. In this study, recycled gypsum decreased the compressive strength of the specimens, which could be prevented by using a finer gypsum powder.
Processing, Phase Stability, and Conductivity of Multication-Doped Ceria
Authors: Gager Elizabeth , Nino Juan C.
Published: July 2023

Multicomponent doping of ceria with four cations is used as a preliminary investigation into the ionic conductivity of high-entropy-doped ceria systems. Different compositions of Ce1-x(Ndx/4Prx/4Smx/4Gdx/4)O2-δ (x = 0.05, 0.10, 0.15, and 0.20) are synthesized using the oxalate co-precipitation method yielding single-phase oxalate precursors. X-ray diffraction, Raman spectroscopy, and Fourier-transform infrared spectroscopy are used to characterize the precipitated oxalates. Simultaneous thermal gravimetric analysis and differential scanning calorimetry reveal a two-step decomposition of the oxalates into the doped oxide. The ionic conductivity of the samples is measured from 250 °C to 600 °C using electrochemical impedance spectroscopy. All samples exhibit similar grain conductivity values at 600 °C, comparable to singly doped samples. However, an increase in total conductivity is observed with an increase in doping concentration up to 15% followed by a decrease beyond this concentration. These findings suggest that multicomponent doping may not significantly enhance the grain conductivity of doped ceria beyond conventional single and co-doped compositions but can modulate the grain boundary conductivity and thus the total conductivity of ceria ceramics.
Semen Cryopreservation for Men Banking for Oligozoospermia, Cancers, and Other Conditions: 24 Years’ Experience of an Italian Bank
Authors: Marchiani Sara , Degl’Innocenti Selene , Dabizzi Sara , Tamburrino Lara , Fino Maria Grazia , Traini Giulia , Calamai Costanza , Maggi Mario , Vignozzi Linda , Baldi Elisabetta , Lotti Francesco
Published: July 2023

Background: Sperm cryopreservation is recommended to preserve male fertility for cancer patients or other medical conditions at risk of sperm decline. Whether motility and viability recovery rates vary depending on the medical conditions requiring cryopreservation is poorly known. We report here on the 24-year experience of our semen bank. Methods: Motility and viability recovery rates were evaluated in 1973 collections from patients with various medical conditions and 67 collections from donors, and the results were related to basal semen quality. Results: Motility and viability recovery were highly related to basal semen quality and varied between cancer and non-cancer conditions, independently of the duration of cryopreservation and patient age. In samples with a sperm number below 2 × 106/mL, recovery rates approximated to zero. The highest recovery rates were found in donor collections. Cut-off values for the recovery of at least 1% motile spermatozoa were established based on initial semen quality. Conclusions: Our results indicate that the occurrence of any pathological or medical condition resulted in lower recovery rates with respect to donors, indicating that intrinsic sperm characteristics drive susceptibility to cryodamage. Established cut-off values for motility recovery can be useful for patient counseling as well as for ART laboratories to decide the type of procedure.
Dyspnea in Post-Acute COVID-19: A Multi-Parametric Cardiopulmonary Evaluation
Authors: Cecchetto Antonella , Guarnieri Gabriella , Torreggiani Gianpaolo , Vianello Andrea , Baroni Giulia , Palermo Chiara , Bertagna De Marchi Leonardo , Lorenzoni Giulia , Bartolotta Patrizia , Bertaglia Emanuele , Donato Filippo , Aruta Patrizia , Iliceto Sabino , Mele Donato
Published: July 2023

Post-acute COVID-19 is characterized by the persistence of dyspnea, but the pathophysiology is unclear. We evaluated the prevalence of dyspnea during follow-up and factors at admission and follow-up associated with dyspnea persistence. After five months from discharge, 225 consecutive patients hospitalized for moderate to severe COVID-19 pneumonia were assessed clinically and by laboratory tests, echocardiography, six-minute walking test (6MWT), and pulmonary function tests. Fifty-one patients reported persistent dyspnea. C-reactive protein (p = 0.025, OR 1.01 (95% CI 1.00–1.02)) at admission, longer duration of hospitalization (p = 0.005, OR 1.05 (95% CI 1.01–1.10)) and higher body mass index (p = 0.001, OR 1.15 (95% CI 1.06–1.28)) were independent predictors of dyspnea. Absolute drop in SpO2 at 6MWT (p = 0.001, OR 1.37 (95% CI 1.13–1.69)), right ventricular (RV) global longitudinal strain (p = 0.016, OR 1.12 (95% CI 1.02–1.25)) and RV global longitudinal strain/systolic pulmonary artery pressure ratio (p = 0.034, OR 0.14 (95% CI 0.02–0.86)) were independently associated with post-acute COVID-19 dyspnea. In conclusion, dyspnea is present in many patients during follow-up after hospitalization for COVID-19 pneumonia. While higher body mass index, C-reactive protein at admission, and duration of hospitalization are predictors of persistent dyspnea, desaturation at 6MWT, and echocardiographic RV dysfunction are associated with this symptom during the follow-up period.
Evidence for Impaired Renin Activity in Postural Orthostatic Tachycardia Syndrome
Authors: Spahic Jasmina Medic , Mattisson Ingrid Yao , Hamrefors Viktor , Johansson Madeleine , Ricci Fabrizio , Nilsson Jan , Melander Olle , Sutton Richard , Fedorowski Artur
Published: July 2023

Background: Postural orthostatic tachycardia syndrome (POTS) is a heterogeneous condition predominantly affecting autonomic control of the cardiovascular system. Its extensive symptom diversity implies multi-organ involvement that interacts in ways still requiring full exploration. Current understanding of POTS pathophysiology suggests alterations in the renin–angiotensin–aldosterone system as a possible contributing factor. Therefore, we investigated the relationship between the activity of the renin–angiotensin–aldosterone system and hemodynamic parameters in a cohort of POTS patients and controls recruited at a tertiary referral center. Methods: The case-control study included 46 patients with POTS (27 ± 9 years), and 48 healthy controls (30 ± 9 years) without orthostatic intolerance. Plasma renin activity, expressed as angiotensin I generation, and plasma aldosterone were measured by enzyme-linked immunosorbent assay and were correlated with hemodynamic parameters obtained during active standing tests. Results: Renin activity was significantly downregulated in POTS patients compared to healthy individuals (median, 3406 ng/mL vs. 9949 ng/mL, p < 0.001), whereas aldosterone concentration did not differ between POTS and healthy controls (median, 218 pmol/L vs. 218 pmol/L, p = 0.26). A significant inverse correlation between renin activity and supine and orthostatic blood pressure levels was observed in healthy individuals (p < 0.05 for all), but not in POTS patients. Conclusions: Renin activity, but not aldosterone concentration, is downregulated in patients with POTS. Moreover, renin activity in POTS is dissociated from supine and standing blood pressure levels in contrast to healthy individuals. These findings suggest impaired renin function in POTS, which may direct future therapeutic approaches.
Liver-Support Therapies in Critical Illness—A Comparative Analysis of Procedural Characteristics and Safety
Authors: Göth Daniel , Mahler Christoph F. , Kälble Florian , Speer Claudius , Benning Louise , Schmitt Felix C. F. , Dietrich Maximilian , Krautkrämer Ellen , Zeier Martin , Merle Uta , Morath Christian , Fiedler Mascha O. , Weigand Markus A. , Nusshag Christian
Published: July 2023

Extracorporeal liver-support therapies remain controversial in critically ill patients, as most studies have failed to show an improvement in outcomes. However, heterogeneous timing and inclusion criteria, an insufficient number of treatments, and the lack of a situation-dependent selection of available liver-support modalities may have contributed to negative study results. We retrospectively investigated the procedural characteristics and safety of the three liver-support therapies CytoSorb, Molecular Adsorbent Recirculating System (MARS) and therapeutic plasma exchange (TPE). Whereas TPE had its strengths in a shorter treatment duration, in clearing larger molecules, affecting platelet numbers less, and improving systemic coagulation and hemodynamics, CytoSorb and MARS were associated with a superior reduction in particularly small protein-bound and water-soluble substances. The clearance magnitude was concentration-dependent for all three therapies, but additionally related to the molecular weight for CytoSorb and MARS therapy. Severe complications did not appear. In conclusion, a better characterization of disease-driving as well as beneficial molecules in critically ill patients with acute liver dysfunction is crucial to improve the use of liver-support therapy in critically ill patients. TPE may be beneficial in patients at high risk for bleeding complications and impaired liver synthesis and hemodynamics, while CytoSorb and MARS may be considered for patients in whom the elimination of smaller toxic compounds is a primary objective.
Functional Outcomes of Brolucizumab-Induced Intraocular Inflammation Involving the Posterior Segment—A Meta-Analysis and Systematic Review
Authors: Garweg Justus G. , Keiper Judith , Pfister Isabel B. , Schild Christin
Published: July 2023

Early poor outcomes of intraocular inflammation (IOI) after intravitreal brolucizumab (IVB) have negatively affected the use of brolucizumab in clinical routine. We wished to identify factors related to the treatment details of IOI involving the posterior segment resulting from IVB for neovascular AMD (nAMD), if these were reported in detail. Articles were retrieved from PubMed, Scopus, ClinicalTrials, and CENTRAL using the following search terms:  AND  AND . The risk of bias was rated using the JBI Critical Appraisal Tool. We included 31 reports (41 patients and 46 eyes). Patients were 75.9 ± 8.5 years, and 58.5% were female. IOI occurred 41.7 ± 37.5 (median 37.0) days after treatment initiation with 2.0 ± 1.3 (1–6) IVB injections. A mean change in visual acuity of −14.6 ± 21.0 (median −6.5) letters was reported. The mean time from first IOI signs to the initiation of any anti-inflammatory treatment was 3.3 ± 6.2 days, with 63% of the patients receiving systemic corticosteroids as standard treatment. Finally, a period effect was observed, with a change in visual acuity of −25.3 ± 27.1 and −2.6 ± 7.3 letters in the chronologically first and last third, respectively, of treated eyes (effect size: r = 0.71; p = 0.006). Functional outcomes markedly improved with increasing experience in managing IOI.
Healing Treatments in COVID-19 Patients: A Narrative Review
Authors: Sixt Thibault , Moretto Florian , Esteve Clementine , Duong Michel , Buisson Marielle , Mahy Sophie , Blot Mathieu , Piroth Lionel
Published: July 2023

Since December 2019, many drugs have been evaluated or advocated as potential treatments of SARS-CoV-2 induced disease (COVID-19), including many repositioned drugs and some others specifically developed for these diseases. They can be roughly classified into three categories according to their main mechanism of action (passive immunization, direct antivirals, and anti-inflammatory treatments), and their use depends on the stage of the disease. Despite often promising preclinical data, most of the treatments evaluated failed to show a significant clinical benefit. In addition, a few others have seen their effectiveness affected by the occurrence of SARS-CoV-2 variants and sub-variants. Herein, the aim of this article is to take stock of the data available as of the 14th of July 2022, concerning the specific healing options evaluated for patients suffering from COVID-19. We focus particularly on healing treatments of COVID-19 and do not deal with preventive treatments such as vaccine. Associated therapies such as venous thromboembolism prophylaxis are not detailed since they are covered in a specific chapter of this issue. Passive immunization, especially through monoclonal antibodies, showed a positive impact on the clinical evolution, whether in outpatients or inpatients without oxygen supply. However, their effectiveness strongly depends on the type of SARS-CoV-2 variant, and often decreases or even vanishes with the most recent variants. Among direct antiviral treatments, ritonavir-boosted nirmatrelvir appears to currently be the cornerstone in the management of early infections, but its use may be limited by drug interactions. Remdesivir remains as an alternative in this situation, even though it is potentially less convenient. Anti-inflammatory treatments have often been shown to be the most effective in inpatients with oxygen supply. Dexamethasone is now a cornerstone of management of these patients. Added tocilizumab seems beneficial in the case of hyper inflammation. JAK inhibitors and anakinra have also gained an interest in some studies. As a conclusion of this narrative review, the best treatment strategy has yet to be defined and is likely to evolve in the future, not only because many other drugs are still under development and evaluation, but also because of the viral epidemics and epidemiology evolution.
Length of Stay in Emergency Department by ICD-10 Specific and Non-Specific Diagnoses: A Single-Centre Retrospective Study
Authors: Miazgowski Bartosz , Pakulski Cezary , Miazgowski Tomasz
Published: July 2023

The definition of non-specific presentation at a hospital emergency department (ED) has not yet been formally established. The purpose of this study was to assess the relationships between primary ED diagnoses identified by ICD-10 codes and ED length of stay (LOS). Over the course of three years, we examined 134,675 visits at a tertiary hospital. LOS was examined in groups with specific (internal, surgical, neurological, and traumatic diseases) and non-specific diagnoses. Our secondary objective was to measure LOS by age, day of the week, time of day, and season. The median LOS was 182 min (interquartile range: 99−264 min). LOS was 99 min in the traumatic group, while it was 132 min in the surgical group, 141 min in the non-specific group, 228 min in the internal medicine group, and 237 min in the neurological group. Other determinants of LOS were age, revisits, day of the week, and time of arrival—but not a season of the year. In the non-specific group (21% of all diagnoses), the percentage of hospitalizations was higher than in the specific groups. Our results suggest that in clinical practice, the non-specific group should be redefined to also encompass diagnoses from ICD-10 Chapter XXI (block Z00–Z99).
Self-Reported Pain and Pain Observations in People with Korsakoff’s Syndrome: A Pilot Study
Authors: Oudman Erik , van der Stadt Thom , Bidesie Janice R. , Wijnia Jan W. , Postma Albert
Published: July 2023

Korsakoff’s syndrome (KS) is a chronic neuropsychiatric disorder. The large majority of people with KS experience multiple comorbid health problems, including cardiovascular disease, malignancy, and diabetes mellitus. To our knowledge pain has not been investigated in this population. The aim of this study was to investigate self-reported pain as well as pain behavior observations reported by nursing staff. In total, 38 people diagnosed with KS residing in a long-term care facility for KS participated in this research. The Visual Analogue Scale (VAS), Pain Assessment in Impaired Cognition (PAIC-15), Rotterdam Elderly Pain Observation Scale (REPOS), and the McGill Pain Questionnaire–Dutch Language Version (MPQ-DLV) were used to index self-rated and observational pain in KS. People with KS reported significantly lower pain levels than their healthcare professionals reported for them. The highest pain scores were found on the PAIC-15, specifically on the emotional expression scale. Of importance, the patient pain reports did not correlate with the healthcare pain reports. Moreover, there was a high correlation between neuropsychiatric symptoms and observational pain reports. Specifically, agitation and observational pain reports strongly correlated. In conclusion, people with KS report less pain than their healthcare professionals indicate for them. Moreover, there is a close relationship between neuropsychiatric symptoms and observation-reported pain in people with KS. Our results suggest that pain is possibly underreported by people with KS and should be taken into consideration in treating neuropsychiatric symptoms of KS as a possible underlying cause.
Analgesic Modalities in Patients Undergoing Open Pancreatoduodenectomy—A Systematic Review and Meta-Analysis
Authors: Mărgărit Simona , Bartoș Adrian , Laza Laura , Osoian Cristiana , Turac Robert , Bondar Oszkar , Leucuța Daniel-Corneliu , Munteanu Lidia , Vasian Horațiu Nicolae
Published: July 2023

Background: This systematic review explored the efficacy of different analgesic modalities and the impact on perioperative outcome in patients undergoing pancreatoduodenectomy. Methods: A systematic literature search was performed on PubMed, Embase, Web of Science, Scopus, and Cochrane Library Database using the PRISMA framework. The primary outcome was pain scores on postoperative day one (POD1) and postoperative day two (POD2). The secondary outcomes included length of hospital stay (LOS) and specific procedure-related complications. Results: Five randomized controlled trials and ten retrospective cohort studies were included in the systematic review. Studies compared epidural analgesia (EA), patient-controlled analgesia (PCA), continuous wound infiltration (CWI), continuous bilateral thoracic paravertebral infusion (CTPVI), intrathecal morphine (ITM), and sublingual sufentanil. The pain scores on POD1 (p < 0.001) and POD2 (p = 0.05) were higher in the PCA group compared with the EA group. Pain scores were comparable between EA and CWI plus PCA or CTPVI on POD1 and POD2. Pain scores were comparable between EA and ITM on POD1. The procedure-related complications and length of hospital stay were not significantly different according to the type of analgesia. Conclusions: EA provided lower pain scores compared with PCA on the first postoperative day after pancreatoduodenectomy; the length of hospital stay and procedure-related complications were similar between EA and PCA. CWI and CTPVI provided similar pain relief to EA.
When Should Spinal Surgery Be Considered for Spinal Metastasis from Non-Small Cell Lung Cancer?—Propensity Score Matched Study between Surgery with Radiotherapy and Radiotherapy Alone
Authors: Park Hyung-Youl , Ha Kee-Yong , Kim Sang-Il , Kim Yeon-Sil , Joh Yongwon , Kim Young-Hoon
Published: July 2023

(1) Background: Although metastatic spine disease is increasing, the debate on therapeutic modality remains due to the heterogeneity of tumors and patients. This study aims to evaluate the efficacies of surgery and risk factors for patients’ survival from potentially unstable spinal metastasis of non-small cell lung cancer; (2) Methods: Twenty-two patients undergoing surgery and radiotherapy (group I) were compared with 22 patients undergoing radiotherapy alone (group II) using propensity score matching in a 1-to-1 format. Clinical outcomes included the performance status and ambulatory status. In addition, independent risk factors for patients’ survival were evaluated, including the molecular targeted therapy for mutations; (3) Results: deterioration in neurologic status was only observed in group II compared to group I (22.7% vs. 0%, p-value = 0.018). In addition, five patients in the surgery group showed improved Frankel grades. Regarding the patients’ survival, a smoking history of more than ten pack-years (hazard ratio (HR) = 12.18), worse performance status (HR = 6.86), and absence of mutations (HR = 3.39) were the independent risk factors; (4) Conclusions: Spinal surgery with radiotherapy could have advantages for improving the neurologic status including ambulation for potentially unstable spine due to metastasis. Thus, surgery should be considered for patients with a longer life expectancy resulting from better performance status and use of the targeted therapy.
Comparing Airway Analysis in Two-Time Points after Rapid Palatal Expansion: A CBCT Study
Authors: Tsolakis Ioannis A. , Kolokitha Olga-Elpis
Published: July 2023

Background: The aim of this study is to investigate the upper airway analysis at two-time points after the rapid maxillary expansion was performed, using cone-beam computed tomography. Methods: Subjects from the Orthodontic Department at the Aristotle University of Thessaloniki with unilateral or bilateral posterior crossbite were screened according to the selection criteria. A sample size calculation was performed, and a total of 14 subjects were recruited. All subjects received a rapid maxillary expansion with a Hyrax-type device as part of their comprehensive treatment. A CBCT was taken before the treatment (T1), immediately after the expansion was completed (T2), and 6 months after (T3). Their upper airway was measured using the CBCT images. Airway volume (V) and minimal cross-sectional area (MCS) were extracted and compared using SPSS to analyze the means. Results: A statistically significant difference was found between all time points regarding both V and MCS (p < 0.001, p = 0.001). There was a statistically significant increase in both V and MCS measurements immediately after RPE expansion (T1-T2) and six months after expansion (T1-T3). Between the end of expansion and 6 months after (T2-T3), there was a decrease in V and no statistical difference in MCS. Conclusions: RPE can significantly increase the volume and minimal cross-sectional area of the nasal passage airway.
An Observational Study to Develop a Predictive Model for Bacterial Pneumonia Diagnosis in Severe COVID-19 Patients—C19-PNEUMOSCORE
Authors: Tanzarella Eloisa Sofia , Vargas Joel , Menghini Marco , Postorino Stefania , Pozzana Francesca , Vallecoccia Maria Sole , De Matteis Francesco Lorenzo , Franchi Federico , Infante Amato , Larosa Luigi , Mazzei Maria Antonietta , Cutuli Salvatore Lucio , Grieco Domenico Luca , Bisanti Alessandra , Carelli Simone , Lombardi Gianmarco , Piervincenzi Edoardo , Pintaudi Gabriele , Pirronti Tommaso , Tumbarello Mario , Antonelli Massimo , De Pascale Gennaro
Published: July 2023

In COVID-19 patients, antibiotics overuse is still an issue. A predictive scoring model for the diagnosis of bacterial pneumonia at intensive care unit (ICU) admission would be a useful stewardship tool. We performed a multicenter observational study including 331 COVID-19 patients requiring invasive mechanical ventilation at ICU admission; 179 patients with bacterial pneumonia; and 152 displaying negative lower-respiratory samplings. A multivariable logistic regression model was built to identify predictors of pulmonary co-infections, and a composite risk score was developed using β-coefficients. We identified seven variables as predictors of bacterial pneumonia: vaccination status (OR 7.01; 95% CI, 1.73–28.39); chronic kidney disease (OR 3.16; 95% CI, 1.15–8.71); pre-ICU hospital length of stay ≥ 5 days (OR 1.94; 95% CI, 1.11–3.4); neutrophils ≥ 9.41 × 109/L (OR 1.96; 95% CI, 1.16–3.30); procalcitonin ≥ 0.2 ng/mL (OR 5.09; 95% CI, 2.93–8.84); C-reactive protein ≥ 107.6 mg/L (OR 1.99; 95% CI, 1.15–3.46); and Brixia chest X-ray score ≥ 9 (OR 2.03; 95% CI, 1.19–3.45). A predictive score (C19-PNEUMOSCORE), ranging from 0 to 9, was obtained by assigning one point to each variable, except from procalcitonin and vaccine status, which gained two points each. At a cut-off of ≥3, the model exhibited a sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 84.9%, 55.9%, 69.4%, 75.9%, and 71.6%, respectively. C19-PNEUMOSCORE may be an easy-to-use bedside composite tool for the early identification of severe COVID-19 patients with pulmonary bacterial co-infection at ICU admission. Its implementation may help clinicians to optimize antibiotics administration in this setting.
Research on the Production of Pigments Based on Composite Pellets in the Recycling of Industrial Waste
Authors: Turakulov Bakhriddin , Zhantasov Kurmanbek , Kolesnikov Alexandr , Smailov Bakyt , Liseitsev Yury
Published: July 2023

This article presents the complex processing of low-grade and substandard chromium ores, as well as sludge tailings, with the production of composite chromium-containing materials and pigments, while improving environmental performance in the Republic of Kazakhstan through the utilization and processing of technogenic raw materials. In this work, to study the physicochemical properties of the starting materials, modern analytical, thermodynamic, chemical, granulometric, as well as computational, mathematical, laboratory, and experimental methods were used. In particular, studies of a method for producing composite pellets for chromite pigments based on industrial technogenic waste of the Republic of Kazakhstan are presented. Based on the results of the experimental studies, composite pellets were obtained, having a compressive strength of 150–220 kg/pellet and containing 49.7% of chromium oxide and 0.5–1.0% of carbon in its composition. The resulting chromite pigment based on the composite pellets is a modification of chromium oxohydroxide with the formula γ-CrOOH. The density of the resulting pigment is 3.4 kg/m3. The chromite pigment based on the composite pellets is recommended for use in various coloring compositions, including using it for printing on cotton and mixed fabrics intended for sewing outerwear.
Excellent Thermal and Dielectric Properties of Hexagonal Boron Nitride/Phenolic Resin Bulk Composite Material for Heatsink Applications
Authors: Danilov Egor A. , Samoilov Vladimir M. , Kaplan Innokenty M. , Medvedeva Elena V. , Stepashkin Andrey A. , Tcherdyntsev Victor V.
Published: July 2023

In the present paper, we report polymer composites based on phenolic resin filled with hexagonal boron nitride; hot compression molding coupled with solution-based mixing were used to manufacture the composites. The paper presents experimental results on the physical and physicochemical properties of the obtained composites: thermal stability in air and argon, dielectric constant and dielectric loss tangent, active electrical resistance, thermal conductivity (mean and anisotropy), and mechanical strength. It is shown that the proposed technique of composite manufacturing, including the application of high-process pressures, makes it possible to obtain materials with high anisotropy of thermal conductivity, extremely high-filler content, and excellent dielectric properties, all of which are very important for prospective highly efficient lightweight heatsink elements for electronic devices. Experimental values of thermal conductivity and dielectric constant were analyzed using known mathematical models. Experimental values for thermal conductivities (up to 18.5 W·m−1·K−1) of composites at filler loadings of 65–85 vol.% are significantly higher than published data for bulk boron nitride/polymer composites.
Taxonomic and Morpho-Functional Photosynthetic Patterns of 18 Intertidal Macroalgal Species in the Guangdong–Hong Kong–Macao Greater Bay Area, China
Authors: He Quan , Liu Linqing , Qin Yujie , Lin Qiang , Ni Guangyan , Chen Binbin , Ma Zengling , Zou Dinghui , Li Gang
Published: July 2023

Macroalgae provide food for microbial, meio- and macro-faunal communities in coastal ecosystems, thus mediating nutrient dynamics and functions in these ecosystems. Because of this vital role, it is important to clarify physiological information about macroalgae as it reflects their growth potential in the field. In this study, we examined the biomass, pigment content, and photosynthetic O2 evolution rate versus irradiance curves of 18 macroalgal species from the intertidal zone of the Guangdong–Hong Kong–Macao Greater Bay Area, China, and investigated their photosynthetic patterns in relation to phyla characteristics, morphology, and growth locations. The results showed that green algae had the highest maximum photosynthetic O2 evolution rate (Pmax), light utilization efficiency (α), and dark respiration (Rd) among the three macroalgal phyla; the sheet-like macroalgal species had the highest Pmax, α, and Rd among the four morphological categories. The macroalgal species in the upper intertidal zone showed higher Pmax and α and lower saturation irradiance (EK) and compensation irradiance (EC) than those species in the lower intertidal location. The PCA results showed that the biomass of sheet-like macroalgal species was positively correlated with factor PC1 (50.34%), and that of finely branched species was negatively correlated with factor PC2 (25.17%). In addition, our results indicate that the light absorption and utilization capabilities of macroalgae could determine whether they could dominate the intertidal zone and that their photosynthetic characteristics could be used as a potential indicator of their biomass distribution in the Greater Bay Area.
A New Species of Free-Living Nematode (Enoplida: Enchelidiidae) from the Mangrove Wetlands of China
Authors: Zhu Huilan , Guo Yuqing , Zhou Haichao , Shih Yi-Jia , Li Fenglan , Lee Fred Wang Fat , Xu Steven Jingliang , Tam Nora Fung Yee
Published: July 2023

A new species, Belbolla mangrove sp. nov., isolated from the mangrove wetlands of Fujian and Zhejiang Provinces in China, is described and illustrated. Belbolla mangrove sp. nov. is characterized by a pharynx with four bulbs, a small gubernaculum with a short dorsocaudal apophysis, four weakly developed precloacal supplements, a conico-cylindrical tail with a terminal spinneret, and the absence of terminal setae. This new species differs from B. vietnamica by the absence of ocelli and the blunt and rounded proximal ends of the spicules. The 18S rDNA GenBank accession numbers of B. mangrove sp. nov. are provided.
Assessing the Potential Regrowth Ability of Microalgae Using Hull Cleaning Wastewater from International Commercial Ships
Authors: Lim Young Kyun , Kim Moonkoo , Shin Kyoungsoon , Kim Taekhyun , Lee Chung Hyeon , Yoon Ji Nam , Baek Seung Ho
Published: July 2023

Ship biofouling is recognized as a significant pathway for the introduction and spread of invasive organisms. The in-water cleaning of ship hulls generates wastewater that includes antifouling paint residues and biofouling organisms, which inevitably leak into the marine environments, resulting in substantial adverse effects on marine ecosystems. To assess the impact of hull cleaning wastewater (HCW) on microalgae, we conducted microcosm experiments using HCW including attached microalgae. The experiments consisted of a total of 12 combined trials, including the following groups: ambient seawater as a control, the 5% HCW group (HCW), and the 5% HCW + nutrient addition group (HCW+N), conducted at temperatures of 15 and 20 °C, respectively. The Chl. a concentrations in the water column in the control group exhibited maximum values on day 1 (5.24 μg L−1 at 15 °C and 12.37 μg L−1 at 20 °C), but those of the treatments were at low levels, below 2 μg L−1 at both temperatures. On the other hand, the Chl. a concentrations on plastic plates were higher in the treatments than in the control group. Specifically, the Fv/Fm ratio in the water column, which indicates photosynthetic activity, was significantly higher in the control group compared to both the HCW and HCW+N groups at 15 and 20 °C (p < 0.05). This suggests that the growth of water column phytoplankton was inhibited following HCW inoculation. However, there were no significant differences in the Fv/Fm on plastic plates between the control and HCW treatment groups, implying that the periphyton maintained a high photosynthetic capacity even in the presence of HCW treatments. The elution of particulate copper in HCW was observed, which was considered as the main reason for the growth of phytoplankton. Our study results suggest that the runoff of HCW in the marine environment has a greater negative effect on phytoplankton than on periphyton, which can lead to changes in microalgae community composition and a decrease in productivity in the marine environment. Therefore, it is crucial to manage HCW runoff based on scientific assessments to minimize the ecological risks associated with the removal of biofilm or slime from ship biofouling during in-water hull cleaning.
Personalized Medicine in Medullary Thyroid Carcinoma: A Broad Review of Emerging Treatments
Authors: Martins Rui Sousa , Jesus Tito Teles , Cardoso Luís , Soares Paula , Vinagre João
Published: July 2023

Medullary thyroid carcinoma (MTC) arises from parafollicular cells in the thyroid gland, and although rare, it represents an aggressive type of thyroid cancer. MTC is recognized for its low mutational burden, with point mutations in RET or RAS genes being the most common oncogenic events. MTC can be resistant to cytotoxic chemotherapy, and multitarget kinase inhibitors (MKIs) have been considered a treatment option. They act by inhibiting the activities of specific tyrosine kinase receptors involved in tumor growth and angiogenesis. Several tyrosine kinase inhibitors are approved in the treatment of advanced MTC, including vandetanib and cabozantinib. However, due to the significant number of adverse events, debatable efficiency and resistance, there is a need for novel RET-specific TKIs. Newer RET-specific TKIs are expected to overcome previous limitations and improve patient outcomes. Herein, we aim to review MTC signaling pathways, the most recent options for treatment and the applications for personalized medicine.
Synchrony 2022: The Role of Neuroinflammation in Behavioral Exacerbations in Autism Spectrum Disorder
Authors: Frankovich Jennifer , Nanda Heer , Mellins Elizabeth D. , Jyonouchi Harumi , Boles Richard G. , Walker Stephen J. , Gaitanis John , Frye Richard E.
Published: July 2023

The BRAIN Foundation (Pleasanton, CA) hosted Synchrony 2022, a medical conference focusing on research for treatments to benefit individuals with neurodevelopmental disorders (NDD), including those with autism spectrum disorders (ASD) [...]
Acute Foot Drop Caused by Intraneural Ganglion Cyst of the Peroneal Nerve: Literature Review and Case Report
Authors: della Vecchia Giuseppe , Baldi Alfonso , Passavanti Maria Beatrice , Lucariello Angela , De Luca Antonio , De Blasiis Paolo
Published: July 2023

Background: Foot drop (FD) is characterized by an inability to lift the foot against gravity because of dorsiflexor muscle weakness. The aim of the present study is to report a clinical case of acute non-traumatic FD in patients with peroneal intraneural ganglion, after performing a scoping review on the methodological management of this disease. Methods: We performed a review of the literature and reported the case of a 49-year-old man with acute FD caused by an intraneural ganglion cyst of the peroneal nerve. Results: Out of a total of 201 articles, 3 were suitable for our review beyond our case report. The acute FD caused by peroneal intraneural ganglion can be managed by a careful clinical–instrumental differential diagnosis. A targeted surgery with subsequent rehabilitation produced a satisfactory motor recovery. Conclusions: Acute FD requires an appropriate diagnostic–therapeutic framework to identify and effectively treat the causes in order to promote complete recovery
Descriptive and Network Post-Occupancy Evaluation of the Urban Public Space through Social Media: A Case Study of Bryant Park, NY
Authors: Zhang Bo , Song Yang , Liu Dingyi , Zeng Zhongzhong , Guo Shuying , Yang Qiuyi , Wen Yuhan , Wang Wenji , Shen Xiwei
Published: July 2023

In modern cities, urban public spaces, such as parks, gardens, plazas, and streets, play a big role in people’s social activities, physical activities, mental health, and overall well-being. However, the traditional post-occupancy evaluation (POE) process for public spaces such as large urban parks is extremely difficult, especially for long-term user experiences through observations, surveys, and interviews. On the other hand, social media has emerged as a major media outlet recording millions of user experiences to the public, which provides opportunities to inform how public space is used and perceived by users. Furthermore, unlike previous research that primarily presented descriptive characters of park programs, our study employs a network model to elucidate the interactive relationships and intensities among reported park elements, human activities, and experiences. This approach enables us to track the sources within the space that impact people’s perceptions, such as weather conditions, food options, and notable landmarks. The utilization of this network model opens avenues for future research to comprehensively investigate the factors shaping people’s perceptions in public open spaces. This study uses Bryant Park as an example and presents a new analytical framework, POSE (post-occupancy social media evaluation), to support long-term POE studies for large public spaces. Methods such as data automation, descriptive statistics, and social network analysis were used. The identification and quantification of meaningful park activities, scenes, and sentiments as well as their relationships will help optimize the design and management of park programs.
Evolution of Ecosystem Service Values and the Response to Landscape Pattern Change in the Huaihe River Eco-Economic Belt
Authors: Wang Ziyun , Wang Huaijun , Liu Zhenjie , Feng Ru , Pan Yingping
Published: July 2023

Land use change has serious impacts on the structure, function, and layout of the landscape pattern, which significantly affects ecosystem service values (ESVs). Based on land use data over a 10-year interval from 1980 to 2020, this study analyzed the evolution characteristics of ESV and landscape ecological security in the Huaihe River Eco-Economic Belt using the equivalent factor method (EFM) and landscape pattern indices. The results show that the following: (1) The ESV of the Huaihe River Eco-Economic Belt has increased by approximately 4% in the past 40 years, primarily characterized by increases in the values of services associated with the water environment (water supply, purifying environment, and hydrological regulation) and decreases in the values of services not associated with the water environment (food production, raw material production, gas conditioning, climate control, soil conservation, nutrient cycle maintenance, and biodiversity). (2) The landscape indices of landscape division index, edge density, marginal entropy, fractal dimension index, and Shannon’s diversity index have shown increasing trends, and human activities in the study area are more widespread and fragmented. (3) Landscape fragmentation significantly reduced the values of non-water services, but the increase in the values of water-related services masked the impact of landscape fragmentation on the total ESV. The EFM overestimated the ESV of the water environment, such as hydrological regulation in areas with a large expansion of the water area, which may introduce uncertainties in the results.
Montane Ecoclines in Ancient Central Asia: A Preliminary Study of Agropastoral Economies in Juuku, Kyrgyzstan
Authors: Chang Claudia , Ivanov Sergei S. , Spengler Robert N. , Mir-Makhamad Basira , Tourtellotte Perry A.
Published: July 2023

In this paper, we use preliminary archaeological data spanning the Iron Age through Medieval periods (ca. 800 BCE to 1200 CE) in the Juuku Valley in Kyrgyzstan on the south side of Lake Issyk-Kul to model land use across vertical mountain zones. We have (1) established a radiometric chronology; (2) conducted test excavations of an Iron Age settlement at 2100 m asl and a Turkic period burial at 1934 m asl; (3) undertaken preliminary archaeobotanical research; and (4) performed pedestrian surveys. Archaeobotanical remains of wheat (Triticum aestivum), barley (Hordeum vulgare), broomcorn millet (Panicum milaceum), foxtail millet (Setaria italica), and legumes were recovered in very small quantities from both sites. We compare these preliminary archaeobotanical results with previously published data from Talgar Iron Age settlements on the north side of the Tian Shan Mountain range in Kazakhstan. A small assemblage of faunal remains found at the Turkic period kurgan and from a profile at the upland Iron Age settlement demonstrates the practice of herding sheep/goats, cattle, and horses in the Juuku Valley. The goal of this study was to test the hypothesis that pastoral transhumance and agropastoralism were interchangeable economic strategies used by peoples in the Iron Age through Medieval periods in mountain-river valleys between 600 m to 2100 m asl. These economic strategies combined the pasturing of sheep, goats, cattle, and horses with the cultivation of cereals in a system that was adapted to different vegetational zones along a vertical gradient. This paper is based on preliminary research using survey data and test excavations and initiates a long-term research study of four millennia of settlements that appear to have ranged from pastoral transhumance and combined mountain agriculture.
Spatial–Temporal Evolution Characteristics and Driving Factors of Rural Development in Northeast China
Authors: Zhang Xiaohan , Wu Haowei , Li Zhihui , Li Xia
Published: July 2023

An assessment of rural development and its driving factors can effectively reflect the characteristics and transformation of rural areas and provide important information for the formulation and implementation of rural development strategies. Taking Northeast China as study area, a rural development index framework was constructed from three dimensions, i.e., basic rural conditions, the state of agricultural development, and farmers’ living standards, based on which the rural development level of each city in Northeast China for the years 2000, 2005, 2010, 2015 and 2020 was assessed. Then, an exploratory spatial data analysis was used to explore the spatial and temporal variations in the rural development level in Northeast China during the period 2000–2020. The driving factors were also analyzed using a geographically and temporally weighted regression model. The results showed that the rural development level showed an increasing trend overall, with a spatial pattern of “high in the central, low in the east and west” in most periods. The degree of spatial agglomeration of the rural development level also showed a strengthening trend overall. The hots spots of rural development were mainly distributed in the Southern and Northern regions, while the cold spots were mostly concentrated in the central, eastern and western regions. Urbanization processes, elevation, annual precipitation and other natural factors have weakened the level of rural development to a certain extent, while agricultural production upgrading, an increase in the general public budget expenditure per capita and the sound financial situation of the government can promote rural development in Northeast China. The effects of the natural environment and local economic conditions on rural development were different in different regions. To improve rural development in the future, we should scientifically grasp the basic conditions, such as rural resource endowment, location conditions, agricultural technology, policies, investment and other external conditions, and formulate regional rural development strategies according to local conditions and in light of local rural characteristics.
Design Element Preferences in Public Facilities: An Eye Tracking Study
Authors: Liu Yumeng , Zhou Zhicheng , Xu Yuanyuan
Published: July 2023

As a highly used form of architecture, public facilities are closely related to people’s daily lives. The aesthetic level of their design greatly affects the quality of people’s lives and interactions, as well as the appearance of the whole area. However, research on their design elements has not received enough attention, and few quantitative studies on the design of public facilities simultaneously focus on multiple influencing factors such as color and material. Therefore, this study uses eye-tracking technology and audience aesthetic preference evaluation to explore the appropriate combination of color and materials in sign design. This study found that, in the design of public facilities and in terms of aesthetic preference, firstly, color has more influence on subjective preference and objective gaze behavior than material. Secondly, men prefer technological and changeable colors and materials, and women prefer soft and uniform materials. Finally, visitors spend more time gazing at their preferred signs, which means that visitors’ top-down gaze behavior and bottom-up psychological perception are highly unified. Regarding material perception, visitors’ subjective preferences are influenced by the physical or cultural properties of the material itself. This study’s results will provide suggestions for future urban and landscape architecture design in terms of color and material aesthetics, and the research methodology can be applied to more scenarios in environmental spaces.