bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of electronic adherence monitoring on adherence and outcomes in chronic conditions: A systematic review and meta-analysis
Authors: Chan Amy Hai Yan , Foot Holly , Pearce Christina Joanne , Horne Rob , Foster Juliet Michelle , Harrison Jeff
Published: March 2022

Introduction

Electronic adherence monitoring (EAM) is increasingly used to improve adherence. However, there is limited evidence on the effect of EAM in across chronic conditions and on patient acceptability. We aimed to assess the effect of EAM on adherence and clinical outcomes, across all ages and all chronic conditions, and examine acceptability in this systematic review and meta-analysis.

Methods

A systematic search of Ovid MEDLINE, EMBASE, Social Work Abstracts, PsycINFO, International Pharmaceutical Abstracts and CINAHL databases was performed from database inception to December 31, 2020. Randomised controlled trials (RCTs) that evaluated the effect of EAM on medication adherence as part of an adherence intervention in chronic conditions were included. Study characteristics, differences in adherence and clinical outcomes between intervention and control were extracted from each study. Estimates were pooled using random-effects meta-analysis, and presented as mean differences, standardised mean differences (SMD) or risk ratios depending on the data. Differences by study-level characteristics were estimated using subgroup meta-analysis to identify intervention characteristics associated with improved adherence. Effects on adherence and clinical outcomes which could not be meta-analysed, and patient acceptability, were synthesised narratively. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guideline was followed, and Risk of bias (RoB) assessed using the Cochrane Collaboration’s RoB tool for RCTs. The review is registered with PROSPERO CRD42017084231.

Findings

Our search identified 365 studies, of which 47 studies involving 6194 patients were included. Data from 27 studies (n = 2584) were extracted for the adherence outcome. The intervention group (n = 1267) had significantly better adherence compared to control (n = 1317), (SMD = 0.93, CI:0.69 to 1.17, p<0.0001) with high heterogeneity across studies (I2= 86%). There was a significant difference in effect according to intervention complexity (p = 0.01); EAM only improved adherence when used with a reminder and/or health provider support. Clinical outcomes were measured in 38/47 (81%) of studies; of these data from 14 studies were included in a meta-analysis of clinical outcomes for HIV, hypertension and asthma. In total, 13/47 (28%) studies assessed acceptability; patient perceptions were mixed.

Interpretation

Patients receiving an EAM intervention had significantly better adherence than those who did not, but improved adherence did not consistently translate into clinical benefits. Acceptability data were mixed. Further research measuring effects on clinical outcomes and patient acceptability are needed.
Disruptions in hepatic glucose metabolism are involved in the diminished efficacy after chronic treatment with glucokinase activator
Authors: Tsumura Yoshinori , Tsushima Yu , Tamura Azusa , Kato Hirotsugu , Kobayashi Tsunefumi
Published: March 2022

Glucokinase activators are regarded as potent candidates for diabetes treatment, however, in clinical studies on patients with type 2 diabetes, a diminishing efficacy was observed after chronic treatment with them. The mechanism of this reduction has not been elucidated, and whether it is a class effect of glucokinase activators remains inconclusive. Here, we firstly identified a diabetic animal model that shows the diminished efficacy after long-term treatment with MK-0941, a glucokinase activator that exhibited diminished efficacy in a clinical study, and we analyzed the mechanism underlying its diminished efficacy. In addition, we evaluated the long-term efficacy of another glucokinase activator, TMG-123. Goto-Kakizaki rats were treated with MK-0941 and TMG-123 for 24 weeks. The results showed that glycated hemoglobin A1C levels and plasma glucose levels decreased transiently but increased over time with the continuation of treatment in the MK-0941-treated group, while decreased continuously in the TMG-123-treated group. Only in the TMG-123-treated group, higher plasma insulin levels were shown at the later stage of the treatment period. For the mechanism analysis, we conducted a hepatic enzyme assay and liver perfusion study in Goto-Kakizaki rats after chronic treatment with MK-0941 and TMG-123, and revealed that, only in the MK-0941-treated group, the activity of glucose-6-phosphatase was increased, and hepatic glucose utilization was decreased compared to the non-treated group. These data indicate that disruptions in hepatic glucose metabolism are involved in the diminished efficacy of glucokinase activators.
Antitumor activity of T cells secreting αCD133-αCD3 bispecific T-cell engager against cholangiocarcinoma
Authors: Sangsuwannukul Thanich , Supimon Kamonlapat , Chieochansin Thaweesak , Choomee Kornkan , Sujjitjoon Jatuporn , Junking Mutita , Yenchitsomanus Pa-thai
Published: March 2022

Cholangiocarcinoma (CCA) is a lethal cancer of bile duct epithelial cells with a high mortality rate and limited therapeutic options. An effective treatment is, therefore, urgently needed to improve treatment outcomes for these patients. To develop a new therapeutic option, we engineered T cells secreting αCD133-αCD3 bispecific T-cell engager and evaluated their antitumor effects against CD133-expressing CCA cells. The cDNA encoding αCD133-αCD3 bispecific T-cell engager (αCD133-αCD3-ENG) was cloned into pCDH lentiviral construct and its expression was tested in Lenti-X 293T cells. T cells from healthy donors were then transduced with engineered lentiviruses to create T cells secreting αCD133-αCD3 engager to evaluate their antitumor activities. The average transduction efficiency into T cells was approximately 60.03±21.65%. In the co-culture system containing T cells secreting αCD133-αCD3 engager (as effector cells) and mWasabi-luciferase-expressing CCA cells (KKU-100 and KKU-213A; as target cells), the effector T cells exhibited significantly higher cytolytic activities against the target CCA cells (49.0±9.76% and 64.10±13.18%, respectively) than those observed against the untransduced T cells (10.97±10.65%; p = 0.0103 and 9.80±11.05%; p = 0.0054) at an effector-to-target ratio of 5:1. In addition, the secreted αCD133-αCD3 engager significantly redirected both transduced T cells and bystander T cells to kill the target CCA cells (up to 73.20±1.68%; p<0.05). Moreover, the transduced and bystander T cells could kill the target CCA spheroids at a rate approximately 5-fold higher than that of the no treatment control condition (p = 0.0011). Our findings demonstrate proof-of-principle that T cells secreting αCD133-αCD3 engager can be an alternative approach to treating CD133-positive CCA, and they pave the way for future in vivo study and clinical trials.
Sustained elevation of soluble B- and T- lymphocyte attenuator predicts long-term mortality in patients with bacteremia and sepsis
Authors: Lange Anna , Cajander Sara , Magnuson Anders , Strålin Kristoffer , Hultgren Olof
Published: March 2022

Soluble B and T lymphocyte attenuator (sBTLA) has been shown to be associated with severity and outcome, in critically ill septic patients. We aimed to assess the dynamic expression of sBTLA, as a prognostic biomarker of long-term mortality in patients with bloodstream infection (BSI) and sepsis, and to evaluate its association with biomarkers indicative of inflammation and immune dysregulation. Secondarily, sBTLA was evaluated in association with severity and bacterial etiology. Patients with BSI (n = 108) were prospectively included, and serially sampled from admission to day 28. Blood and plasma donors (n = 31), sampled twice 28 days apart, served as controls. sBTLA concentration in plasma was determined with enzyme-linked immunosorbent assay. Associations between sBTLA on day 1–2 and 7, and mortality at 90 days and 1 year, were determined with unadjusted, and adjusted Cox regression. Differences related to severity was assessed with linear regression. Mixed model was used to assess sBTLA dynamics over time, and sBTLA associations with bacterial etiology and other biomarkers. sBTLA on day 1–2 and 7 was associated with mortality, in particular failure to normalize sBTLA by day 7 was associated with an increased risk of death before day 90, adjusted HR 17 (95% CI 1.8–160), and one year, adjusted HR 15 (95% CI 2.8–76). sBTLA was positively associated with CRP, and negatively with lymphocyte count. sBTLA on day 1–2 was not linearly associated with baseline SOFA score increase. High SOFA (≥4) was however associated with higher mean sBTLA than SOFA ≤3. sBTLA was not associated with bacterial etiology. We show that sustained elevation of sBTLA one week after hospital admission is associated with late mortality in patients with BSI and sepsis, and that sBTLA concentration is associated with CRP and decreased lymphocyte count. This suggests that sBTLA might be an indicator of sustained immune-dysregulation, and a prognostic tool in sepsis.
Keep your budget together! Investigating determinants on risky decision-making about losses
Authors: Wyszynski Marc , Diederich Adele
Published: March 2022

The present study investigates the influence of framing, different amounts to lose, and probabilities of a risky and sure choice option, time limits, and need on risky decision-making. For a given block of trials, participants were equipped with a personal budget (number of points). On each trial within a block, a specific initial amount is possibly taken from the budget by the outcome of a gamble or the choice of a sure loss option. The goal was to avoid losing points from the budget for not falling below a predefined need threshold. Three different levels of induced need were included. Employing a psychophysical experimental approach, we furthermore tested a sequential component of human risk behavior towards a need threshold inspired by research on animal foraging behavior. Risk-sensitivity models and the Stone-Geary framework serve as generating hypotheses on need thresholds. We found that framing, need, and probabilities influenced risky choices. Time limits and initial amounts moderated the framing effect. No sequential component was observed.
Measurement properties of outcome measures used in neurological telerehabilitation: A systematic review protocol
Authors: Brito Sherindan Ayessa Ferreira de , Scianni Aline Alvim , Peniche Paula da Cruz , Faria Christina Danielli Coelho de Morais
Published: March 2022

Several measurement tools commonly used in face-to-face neurological rehabilitation have been used in telerehabilitation. However, it is not known whether these tools have adequate measurement properties and clinical utility. This systematic review aims to investigate the measurement properties and the clinical utility of measurement tools used in telerehabilitation in individuals with neurological diseases. A systematic review to investigate the measurement properties and clinical utility of measurement tools used in telerehabilitation in individuals with neurological conditions will be conducted. This systematic review will follow the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) statement. this systematic review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) on 28 May 2021 (registration number: CRD42021257662). Electronic searches will be performed in following databases: Medical Literature Analysis and Retrieval System Online (MEDLINE Ovid), Excerpta Medica Database (Embase Classic + Embase Ovid), Physiotherapy Evidence Database (PEDro), Scientific Electronic Library Online (Scielo), and Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS). Two trained independent reviewers will select the studies according to the inclusion criteria, and will also extract the data, evaluate the clinical utility and methodological quality. The relevant data such as design, participants, settings, and mode of administration, measurement properties, and clinical utility will be summarized. Disagreements between reviewers will be resolved by consensus or by the decision of a third independent reviewer. Hand searches of other relevant studies will be employed. The COnsensus-based Standards for the selection of health Measurement Instruments (COSMIN) checklist and the clinical utility scale will be used to assess the methodological quality and clinical utility of these tools, respectively. This systematic review will provide information regarding the measurement properties and the clinical utility of the measurement tools used in neurological telerehabilitation. This information will be useful to assist health professionals in choosing adequate measurement tools and planning new research studies.
About the time evolution of coherent electron states in monolayers of boron allotropes
Authors: Díaz-Bautista Erik
Published: March 2022

In this paper, we theoretically analyze the massless Dirac fermion dynamics in twodimensional monolayers of boron allotropes, 8B and 2BH − pmmn borophene, interacting with external electric and magnetic fields. We study the effect of the Dirac cone tilt in these materials, which is known as valley index, through the time evolution of probability density of coherent electron states as well as their phase-space representation obtained via the Wigner function. Our results show that the time evolution of the coherent electron states in these materials is valley dependent, which is reinforced in the presence of external electric fields.
On the Wess-Zumino Model: a supersymmetric field theory
Authors: Kulshreshtha Daya Shankar , Kulshreshtha Usha
Published: March 2022

We consider the free massless Wess-Zumino Model in 4D which describes a supersymmetric field theory that is invariant under the rigid or global supersymmetry transformations where the transformation parameter ϵ (or ϵ ) is a constant Grassmann spinor. We quantize the theory using the Hamiltonian and path integral formulations.
How to understand the structure of beta functions in six-derivative Quantum Gravity?
Authors: Rachwał Lesław
Published: March 2022

We extensively motivate the studies of higher-derivative gravities, and in particular we emphasize which new quantum features theories with six derivatives in their definitions possess. Next, we discuss the mathematical structure of the exact on the full quantum level beta functions obtained previously for three couplings in front of generally covariant terms with four derivatives (Weyl tensor squared, Ricci scalar squared and the Gauss-Bonnet scalar) in minimal six-derivative quantum gravity in d = 4 spacetime dimensions. The fundamental role here is played by the ratio x of the coupling in front of the term with Weyl tensors to the coupling in front of the term with Ricci scalars in the original action. We draw a relation between the polynomial dependence on x and the absence/presence of enhanced conformal symmetry and renormalizability in the models where formally x → +∞ in the case of four- and six-derivative theories respectively.
Modified Korteweg-de Vries equation as a system with benign ghosts
Authors: Smilga Andrei
Published: March 2022

We consider the modified Korteweg-de Vries equation, uxxx + 6u2ux + ut = 0, and explore its dynamics in spatial direction. Higher x derivatives bring about the ghosts. We argue that these ghosts are benign, i.e., the classical dynamics of this system does not involve a blow-up. This probably means that the associated quantum problem is also well defined.
A note on entanglement classification for tripartite mixed states
Authors: Zhao Hui , Liu Yu-Qiu , Wang Zhi-Xi , Fei Shao-Ming
Published: March 2022

We study the classification of entanglement in tripartite systems by using Bell-type inequalities and principal basis. By using Bell  unctions and the generalized three dimensional Pauli operators, we present a set of Bell inequalities which classifies the entanglement of triqutrit fully separable and bi-separable mixed states. By using the correlation tensors in the principal basis representation of density matrices, we obtain separability criteria for fully separable and bi-separable 2 ⊗ 2 ⊗ 3 quantum mixed states. Detailed example is given to illustrate our criteria in classifying the tripartite entanglement.
Indoor air quality and early detection of mould growth in residential buildings: a case study
Authors: Brambilla Arianna , Gocer Ozgur , Candido Christhina
Published: March 2022

Mould growth affects 1 in 3 homes, and it is the biggest cause for complaints and litigations filed to the relevant authorities in Australia, while significantly affecting the physical and psychological health of the building occupants. Indoor mould is caused by excessive dampness, resulting from poor architectural specification, construction and maintenance practices, as well as inappropriate occupants’ behaviour. The consequences range from early biodeterioration of building materials, requiring anticipated renovation works, to deterioration of the indoor environment, posing a serious threat to the building occupants. This study investigates indoor air quality and mould growth, providing a snapshot of the current indoor air quality of Australian residential buildings regarding air pollutants. It uses a case study representative of the typical Australian suburban home to investigate the effects of unnoticed mould growth. Results of the monitoring campaign indicate that buildings with a high concentration of fungal spores are also more likely to present poor indoor air quality levels, high concentrations of particulate matters (PM
10 and PM
2.5) and CO
2. This research suggests the need for the development of early detection strategies that could minimize the health hazard to people, thereby preventing the need for a major renovation.
As fontes gramaticais e a divisão de conteúdos da De Institutione Grammatica Libri Tres (1572) de Manuel Álvares
Authors: Kaltner Leonardo , Lopes Janaina Fernanda de Oliveira
Published: March 2022

No presente artigo, fruto de pesquisa desenvolvida no grupo de pesquisas Filologia, línguas clássicas e línguas formadoras da cultura nacional (FILIC/CNPq/UFF), no campo da Historiografia da Linguística, mais especificamente no campo da História da Gramática, ou Gramaticografia, investigamos a obra De Institutione Grammatica Libri Tres (1572) de Pe. Manuel Álvares, SJ (1526-1583). Iniciamos nosso texto com a contextualização da obra gramatical e analisamos as fontes gramaticais antigas utilizadas pelo humanista português. Na segunda parte de nosso estudo, apresentamos a divisão de conteúdos da gramática de Álvares, descrevendo o sumário da obra quinhentista, que teve grande impacto no pensamento linguístico do mundo europeu e da América portuguesa, entre os séculos XVI e XVIII. A obra é de interesse para a Historiografia da Linguística no Brasil. A sequência de conteúdos gramaticais encontrada teve continuidade em textos modernos que descrevem a língua latina, sendo ainda a obra influente, indiretamente, na tradição gramatical ocidental.
MENGGAGAS FUNGSI-FUNGSI STRATEGIS LAYANAN CORNER DI PERPUSTAKAAN IAIN KUDUS
Authors: Buwana Radiya Wira
Published: March 2022

The IAIN Kudus library has three corner services that can be used by the entire academic community on the IAIN Kudus campus. The three corner services are the IAIN Kudus corner, the religious moderation corner, and the Asia Foundation corner. This study aims to find out what strategic functions can be applied to the corner service at the IAIN Kudus Library so that the corner service can support the role of the IAIN Kudus Library as a central source of information for the entire academic community at IAIN Kudus. This research was conducted with a descriptive research approach. The object of research is the three service corners in the IAIN Kudus Library. The data collection method used in this research is through observation data collection methods and data collection methods through literature studies. The observation data collection method was used by researchers to observe the corner services in the IAIN Kudus Library. Then the literature study used is through books and journal articles which according to the researcher are in accordance with the research theme. The data that has been obtained in this study were then analyzed descriptively. The results of this study indicate that the strategic functions that can be applied at the corner service of the IAIN Kudus Library include the identity function, deposit-promotive function, learning support function, collaborative function, and research function.
Beyond S&OP Implementation: A maturity model and meta-framework for assessing and managing evolution paths
Authors: Rampon Neto João , Barcellos Paulo Fernando Pinto , Panizzon Mateus
Published: March 2022

Goal: The purpose of this paper is to present an S&OP meta-framework that combines specific S&OP tools and an original S&OP maturity model as an approach to reduce uncertainty and increase commitment in the S&OP implementation process.
Design/ Methodology/ Approach: A systematic review led to the development of a six-pillar S&OP tool framework. Then, a maturity model and an S&OP implementation meta-framework, were defined for managing the introduction and evolution of S&OP dimensions.
Results: The S&OP maturity model provides a structured model for identifing critical gaps in the S&OP process. Furthermore, the S&OP meta-framework - combining Action Research (AR), Kotter’s 8 steps, and agile project management approaches - provides an holistic implementation guide for promoting large-scale transformation in S&OP implementation efforts.
Limitations of the investigation: The S&OP maturity model and implementation system are new empirical contributions to the literature and have not been validated in this article.
Practical implications: This work provides a set of tools to address specific S&OP environments; a maturity model to diagnose the S&OP process; and an S&OP implementation framework to reduce uncertainty and increase commitment in the change process.
Originality / Value: This article fills a literature gap of necessary S&OP implementation practices, contributing to: (1) an S&OP tools framework, (2) an S&OP maturity model based on evolutionary boundaries correlated to the presence of specific tools, processes and metrics, and (3) an S&OP implementation meta-framework, raising awareness in under researched S&OP dimensions for more oriented research and practices needed to promote sustainable change.
Analysis of a Bike-Sharing System from a Business Model Perspective
Authors: Moro Suzana Regina , Cauchick-Miguel Paulo Augusto
Published: March 2022

Goal: Product-service systems are innovative business models that aim to contribute to sustainability issues. Bike-sharing system is a classic example of this kind of business model. This work covers an analysis of a bike-sharing system implemented in the South of Brazil from a business model perspective by focusing on the value network.
Design/Methodology/Approach: Data was collected based on interviews with the executives of a focal company and information retrieved from other sources, e.g., company internal reports, PSS design documents, etc.). A research protocol was developed based on the literature to identify a set of variables to be interpreted. A semi-structured questionnaire was developed for interviews, which was recorded for later content transcription and analysis.
Results: The business model value network and mechanisms of value proposition, configuration, delivery, and value capture are described. This business model is based on a diverse value network and should be developed and updated on co-creation mechanisms to deliver more sustainable results.
Limitation of the investigation: It is a single study conducted in a medium-sized town in the South of Brazil that implemented a bike-sharing system. In addition, the analyis was considered in the “problem identification phase”.
Practical implications: The bike-sharing business model analysis may improve the business model towards increasing the inhabitants' quality of life as well as city image.
Originality/Value: The study was conducted in a developing country, analyzing a PSS business model from a sustainable operations perspective, which is not common in the current literature.
Zrozumieć wykrzyknik
Authors: Szczepańska Elżbieta
Published: March 2022

Monika Krzem pek, Zrozumieć wykrzyknik. Semantyka czeskich wykrzykników, Opole: Wydawnictwo Uniwersytetu Opolskiego, 2020, ISBN 978-83-7395-909-5.
Effect of Chelation Therapy on a Korean Patient With Brain Manganese Deposition Resulting From a Compound Heterozygous Mutation in the SLC39A14 Gene
Authors: Lee Jae-Hyeok , Shin Jin-Hong
Published: March 2022

Mutations in the manganese transporter gene SLC39A14 lead to inherited disorders of manganese metabolism. Chelation therapy with edetate calcium disodium (CaNa2EDTA) is known to effectively reduce manganese deposition. We describe the first identified Korean case of SLC39A14-associated manganism and the treatment response to a 5-year chelation therapy. An 18-year-old female presented with childhood-onset dystonia. Magnetic resonance imaging showed T1 hyperintensity throughout the basal ganglia, brainstem, cerebellum, cerebral and cerebellar white matter, and pituitary gland. Blood manganese levels were elevated, and whole-exome sequencing revealed compound heterozygous mutations in SLC39A14. Treatment with intravenous CaNa2EDTA led to a significant reduction in serum manganese levels and T1 hyperintensities. However, her dystonia improved insignificantly. Hence, early diagnosis of this genetic disorder is essential because it is potentially treatable. Even though our treatment did not significantly reverse the establish deficits, chelation therapy could have been more effective if it was started at an earlier stage of the disease.
Chemical composition and ages of four globular clusters in M31 from the analysis of their integrated-light spectra
Authors: Sharina Margarita Eugene , Maricheva Margarita Igorevna
Published: March 2022

We compare the results on the chemical composition of four globular clusters (GCs) in M31 (Bol 6, Bol 20, Bol 45, and Bol 50) (Maricheva M. 2021. Study of integrated spectra of four globular clusters in M 31. Astrophys. Bull. 76:389–404. doi: https://doi.org/10.1134/S199034132104009X) to the available literature data on integrated-light spectroscopy of GCs with similar ages and chemical abundances in our Galaxy and M31 and on the chemical abundances of stars in two galaxies. The clusters and their literature analogues are of moderate metallicity

−
1.1
<

[

Fe/H

]

<
−
0.75

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dex and old (10 Gyr). Mg, Ca, and C abundances of four GCs are higher than literature estimates for the GCs in M31 with

[

Fe/H

]

∼
−
1

\left[\hspace{0.1em}\text{Fe/H}\hspace{0.1em}] \sim -1

dex obtained using high-resolution integrated-light spectroscopy methods. Using literature data, we did not find complete analogues for the studied clusters in our Galaxy and M31 in terms of age, helium mass fraction (

Y

Y

), and chemical composition. The alpha-element abundances in four clusters are about 0.2 dex higher than the average for stars in the Galactic field at

[

Fe/H

]

∼
−
1

\left[\hspace{0.1em}\text{Fe/H}\hspace{0.1em}] \sim -1

dex. We suggest that these and M. Maricheva’s (Maricheva M. 2021) findings about lower metallicities of the studied objects than the average metallicity of red giants in the M31 halo and about the abundances of alpha-process elements in them corresponding to the average value for stars in the M31 inner halo likely indicate that the star formation process in the vicinity of M31 at the time of our sample cluster formation was complex with the inflow of fresh gas from the intergalactic medium and violent star forming events associated with SNe II bursts.
Determination of individual bile acids in acute respiratory distress syndrome reveals a specific pattern of primary and secondary bile acids and a shift to the acidic pathway as an adaptive response to the critical condition
Authors: Harnisch Lars-Olav , Mihaylov Diana , Bein Thomas , Apfelbacher Christian , Kiehntopf Michael , Bauer Michael , Moerer Onnen , Quintel Michael
Published: March 2022

Objectives

Cholestasis and elevated serum bile1 acid levels are common in critically ill patients. This study aims to define the specific pattern of bile acids associated with acute respiratory distress syndrome (ARDS) and the changes in pattern over time.

Methods

Prospective observational study. Serum samples of 70 ARDS patients were analyzed for primary bile acids (cholic acid, chenodeoxycholic acid) and secondary bile acids (deoxycholic acid, litocholic acid, and ursodeoxycholic acid) as well as their glycine and taurine glycation products.

Results

Primary bile acid levels increased from day zero to day five by almost 50% (p<0.05). This change bases on a statistically significant increase in all primary bile acids between day 0 and day 5 (cholic acid [CA] p=0.001, taurocholic acid [TCA] p=0.004, glycocholic acid [GCA] p<0.001, chenodeoxycholic acid [CDCA] p=0.036, taurochenodeoxycholic acid [TCDCA] p<0.001, glycochenodeoxycholic acid [GCDCA] p<0.001). Secondary bile acids showed predominantly decreased levels on day 0 compared to the control group and remained stable throughout the study period; the differences between day zero and day five were not statistically significant. Non-survivors exhibited significantly higher levels of TCDCA on day 5 (p<0.05) than survivors. This value was also independently associated with survival in a logistic regression model with an odds ratio of 2.24 (95% CI 0.53–9.46).

Conclusions

The individual bile acid profile of this ARDS patient cohort is unique compared to other disease states. The combination of changes in individual bile acids reflects a shift toward the acidic pathway of bile acid synthesis. Our results support the concept of ARDS-specific plasma levels of bile acids in a specific pattern as an adaptive response mechanism.
Topoanalysis and the City Space in the Literary Writings of Amitava Kumar
Authors: Anand Ajit , Tripathi Priyanka
Published: March 2022

In the postmodernist transnational moment, the “city” is a “distinctive location of diasporic dwelling, belonging and attachment” and that the city as home is rooted in “city-specific memories” (Blunt and Bonnerjee 237). Emotions and feelings are not static in nature; the very place where one is born becomes a memory house once the individual moves out. Thus, with dispersion, the spaces of “home” transcend to other physical aspects related to it, i.e., the “locality, town or city spaces” (Roy 141) where one has spent a considerable amount of time. Gaston Bachelard in his formulation of “topoanalysis” analyzes the subjective phenomenological expressionvis-à-vis“home” and contends that memories of it are not something remembered, but rather, are entwined with the present. From the literary writings of Amitava Kumar, whose major setting is his hometown “Patna,” the article considers the “city” as a sentimental space of “home” that often forms the core of his varied literary works and manifested through the diasporic consciousness of the author. His literary writings, such asPassport Photos,Bombay-London-New YorkandA Matter of Rats, showcase the author’s constant negotiation of Patna. The literary texts under consideration explore how Kumar extrapolates through his “sense of place” (Agnew in Creswell 7), where “home” becomes an instrument of “topoanalysis” (Bachelard 8). Using Kumar’s literary texts as a literary example, this article offers new ways into thinking of the associated concerns of diaspora, home, city spaces and topoanalysis.
Prozeß-zustandsorientiert instand halten
Authors: Niemeier Frank , Redeker Georg
Published: March 2022

Aus dem Ziel einer effizienten Sicherung der Verfügbarkeit von Produktionsanlagen resultiert die Forderung nach einer möglichst zustandsorientierten Instandhaltung sowie einer Integration von Instandhaltern und Instandhaltungstätigkeiten in Produktionsgruppen. Diese Forderung wird erfüllt durch den Ansatz einer prozeß-zustandorientierten Instandhaltung, die im folgenden Beitrag vorgestellt wird.
Planung neuer Instandhaltungsstrategien
Authors: Hirschmann Joachim
Published: March 2022

Die erforderliche Transparenz in der Instandhaltung (IH) kann nur durch die Nutzung und Integration eines modernen Planungs-Tools erfüllt werden. Ein solches Werkzeug sollte dabei sowohl die Anlagenstruktur als auch die Produktionsabläufe, Maßnahmen und die organisatorischen Aspekte in der Produktion und Instandhaltung berücksichtigen. Der vorliegende Beitrag zeigt anhand von Praxisbeispielen, wie ein IH-Management aussehen, was es leisten kann und welche Potentiale sich damit erschließen lassen.
Vermessung rotierender Werkzeuge in HSC-Fräsmaschinen
Authors: Rall Klaus , Findeklee Joachim , Steinhoff Karsten
Published: March 2022

Die Idee dieses neuen Verfahrens zur Steigerung der Arbeitsgenauigkeit beim HSC-Fräsen ist, die erforderlichen Werkzeugdaten wie Durchmesser bzw. Werkzeugkontur nicht extern im Rahmen einer Werkzeugvoreinstellung, sondern in der HSC-Fräsmaschine am mit Betriebsdrehzahl rotierenden Werkzeug zu messen. In diesem Beitrag werden zwei verschiedene Vermessungsverfahren vorgestellt.
Montagesysteme für langfristige Stückzahlschwankungen
Authors: Reinhart Gunther , Dürrschmidt Stephan
Published: March 2022

Im Rahmen eines Gemeinschaftsprojekts

Gefördert von der Deutschen Forschungsgemeinschaft im Rahmen des Transferbereichs 2

des Instituts für Werkzeugmaschinen und Betriebswissenschaften (iwb) an der TU München und der Schaltbau AG wurde ein teilautomatisiertes, an langfristige Stückzahlveränderungen anpaßbares Montagesystem entwickelt, das zu jedem Zeitpunkt im optimalen Betriebspunkt arbeitet.
Prozeßoptimierung durch Integration von Workflow-Management in PPS-Systeme
Authors: Much Detlef
Published: March 2022

Zur Unterstützung der Ablauforganisationen in Produktionsunternehmen gibt es in jüngster Zeit Bestrebungen, Workflow-Management- und PPS-Systeme zu kombinieren, um eine ganzheitliche EDV-Lösung zu erhalten. Vor diesem Hintergrund werden in dem vorliegenden Beitrag der Realisierungsstand dieser Anforderungen in Standard-PPS-Systemen überprüft und schließlich ein Ansatz zur besseren Prozeßoptimierung aufgezeigt.
Autonome flexible Fertigungssegmente
Authors: Specht Dieter , Heina Jürgen , Metzdorf Dirk
Published: March 2022

Flexible Fertigungssegmente übernehmen Kostenverantwortung für die erstellten Produkte und Leistungen. In diesem Beitrag wird ein Kennzahlensystem vorgeschlagen, das unter Berücksichtigung indirekter Prozesse eine effektive Steuerung dieser Bereiche unterstützt.
Einführung eines gruppenarbeitorientierten Entgeltsystems
Authors: Neumann Frank
Published: March 2022

Das Wecken der Wissenspotentiale der Mitarbeiter eines Unternehmens durch Gruppenarbeit ist ein neuer Ansatz der in der letzten Zeit öfter eine Anwendung findet. Der vorliegende Beitrag beschreibt aufbauend auf diesen Ansatz ein erfolgs- oder leistungsorientiertes Entgeltmodell und zeigt, daß gerade die viel diskutierte Standortsituation Deutschland gleichzeitig auch eine Reihe von Chancen birgt.
Dr. Székács István pszichoanalitikus „brigádnaplója”
Authors: Papp Barbara
Published: March 2022

Székács István kiképző pszichoanalitikus 80. születésnapjára (1987) tanítványai fotóalbumot készítettek. A Brigádnapló feliratú műbőr füzet tartalmaz ugyan átlagosnak tekinthető felvételeket is – Székács a csoporttal stb. –, ám a legtöbb kép sajátos portré: az oldalakon általában egy-egy terapeutáról készült fénykép található, grafikus elemekkel, mókás vagy rejtélyes feliratokkal (e szövegek természetesen csak a beavatatlan szemlélők számára tűnnek rejtélyesnek). Az idős mester előtt tisztelgők – akik hivatásuknál fogva mások mélyebb önismeretének megszerzését segítik – görbe tükörbe néztek és a pillanatot meg is örökítették, a végeredményt pedig ajándékba adták a kiképzőjüknek. Az így készült fotók amellett, hogy Székács pályájáról mesélnek, bepillantást engednek a pszichoterapeuták életébe, és sajátos forrásul szolgálnak a rendszerváltás körül újraéledő és -szerveződő pszichoanalitikus közösség történetéhez. 

Fotó: Brigádnapló
The effect and mechanism of Grim 19 on mouse sperm quality and testosterone synthesis
Authors: Zhao Yue , Liu Haoran , Yang Yang , Huang Wenqian , Chao Lan
Published: March 2022

Abnormal sperm parameters such as oligospermia, asthenospermia, and teratozoospermia result in male factor infertility. Previous studies have shown that mitochondria play an important role in human spermatozoa motility. But the related pathogenesis is far from elucidated. The aim of this study was to investigate the association between gene associated with retinoid-interferon-induced mortality 19 (GRIM19) and asthenospermia. In this study, Grim19 knockout model (Grim19+/− mouse) was created through genome engineering. We showed that compared with WT mice, the sperm count and motility of Grim19+/− mice were significantly reduced. Grim19 may contribute to sperm count and vitality by influencing the mitochondrial membrane potential, intracellular reactive oxygen species production, and increasing cell apoptosis. The spermatogenic cells of all levels in the lumen of the seminiferous tubules were sparsely arranged, and the intercellular space became larger in the testis tissue of Grim19+/− mice. The serum testosterone concentration is significantly reduced in Grim19+/− mice. The expression of steroid synthesis-related proteins STAR, CYP11A1, and HSD3B was decreased in Grim19+/− mice. To further confirm whether changes in testosterone biosynthesis were due to Grim19 downregulation, we validated this result using Leydig cells and TM3 cells. We also found that Notch signaling pathway was involved in Grim19-mediated testosterone synthesis to some extent. In conclusion, we revealed a mechanism underlying Grim19 mediated spermatozoa motility and suggested that Grim19 affected the synthesis of testosterone and steroid hormones in male mouse partly through regulating Notch signal pathways.
Trabajadores de centros deportivos fitness percepción de liderazgo, engagement y estrés
Authors: Barbado Solorzano J.C. , Martínez-Moreno A.
Published: March 2022

El objetivo del estudio fue determinar la influencia del liderazgo, engagement y estrés percibido en trabajadores de centros deportivos fitness. Realizando un estudio cuantitativo, descriptivo de corte transversal. La muestra compuesta por 106 trabajadores, con una edad media de 35 años (35.2 ± 8.5). Los instrumentos utilizados fueron, Multifactor Leadership Questionnaire (MLQ-6S) para medir el tipo de liderazgo; la Utrecht Work Engagement Scale (UWES) para saber el nivel de engagement y Perceived Stress Scale (PSS), para conocer la percepción del estrés. Se comparan y correlacionan variables, t-Student, ANOVA y correlación lineal de Pearson (r) y regresión lineal múltiple. Los principales resultados resaltan que el nivel de estrés percibido es mayor en trabajadores fijos (20.97) y mujeres (21.54). A modo de conclusión indicar que un mayor nivel de engagement se traduce en un menor nivel de estrés percibido.
Validez convergente de nps y valoración de modelos de lealtad en servicios deportivos
Authors: Dalmau Torres J.M. , Gargallo Ibort E. , Tamayo Fajardo J.A. , Nuviala Nuviala A.
Published: March 2022

El fin del trabajo es determinar la validez de Net-Promoter-Score para medir la lealtad y comparar dos modelos que relacionan dimensiones de la calidad, valor, satisfacción y lealtad. En primer lugar, se determinó la validez convergente de Net-Promoter-Score en usuarios de servicios deportivos mediante una correlación entre ambos instrumentos. Posteriormente, se pusieron a prueba los dos modelos, utilizando en el primero Net-Promoter-Score y, en el segundo, una escala multidimensional que mide las intenciones futuras, en ambos casos se utilizó el mismo instrumento para valorar calidad, valor y satisfacción. Se realizó un análisis factorial confirmatorio de los modelos, con el objeto de comprobar la estabilidad de ambos. Los resultados obtenidos demuestran que los dos instrumentos son válidos para medir la lealtad de los usuarios de servicios deportivos y que el modelo que utiliza la escala multidemensional proporciona más información para la toma de decisiones de los responsables de la gestión.
Heredabilidad de las potencialidades físico-deportivas de padres a hijos: Dermatoglifia computarizada
Authors: Gastélum-Cuadras G.
Published: March 2022

El presente trabajo toma un diseño de investigación de estudio de casos múltiples. Se analizaron cuatro familias, conformadas por dos padres y dos hijos, con diferente nivel de involucramiento en el deporte.  A través de la metodología de dermatoglifia dactilar deportiva. Objetivo: demostrar, la heredabilidad genética de las potencialidades físicas de padres a hijos, la correlación entre patrones dermatoglíficos y el rendimiento deportivo; así como la efectividad de un sistema dermatoglífico informatizado. Resultados: se demuestra relación hereditaria entre padres e hijos, a través del método dermatoglífico informatizado, en algunos casos cada padre hereda sus potencialidades a un hijo diferente, en otro es la madre la que otorga a ambos hijos. Además, las familias donde existe un fuerte involucramiento y más cercano al alto rendimiento, cuenta con hijos con más éxitos deportivos. Se confirma la validez y confiabilidad del instrumento, demostrando capacidad de precisión, eficiencia y eficacia para el estudio científico.
Fuerza, velocidad de marcha y tiempo de reacción en adultos mayores activos
Authors: Al Nayf Mantas M.R. , Párraga-Montilla J. , Lozano-Aguilera E. , López-García S. , Moral-García J.E.
Published: March 2022

El envejecimiento implica pérdida de funcionalidad, existiendo una asociación entre mayores niveles de fuerza, de velocidad de marcha y de tiempo de reacción con un buen estado de salud. El objetivo es analizar el nivel de capacidades físicas y perceptivas de los participantes en un programa de actividad física. Participaron 170 adultos mayores (93 mujeres), de 65±6,8 años. La fuerza se midió con el press de banca, test de la silla y la prensión manual. La velocidad de la marcha en 8 y 30 m se midió con células fotoeléctricas y el tiempo de reacción con sistema optogait. Los resultados muestran un buen nivel de condición física, siendo los más mayores más lentos y con peor reacción a un estímulo. La fuerza disminuye al avanzar la edad, pero puede mantenerse en óptimos niveles con la práctica regular de actividad física.
Natación artística en niñas: antropometría, genotipo y rendimiento deportivo
Authors: Romero-Lorca A. , De la Calle L. , Novillo A. , Fernández-Santander A. , Blanco M.A. , Rodelgo T. , Andreu-Vázquez C. , Gaibar M.
Published: March 2022

En cada deporte es importante optimizar peso y composición corporal y la genética y los datos antropométricos pueden influir en rendimiento deportivo y salud, sobre todo en deportistas menores.

Este estudio analiza 60 nadadoras artísticas entre 9 y 17 años, divididas en tres grupos de edad: ?12, 13-15 y 16-17 años. Se realizó un análisis de medidas antropométricas, edad de menarquia, genotipo relacionado con rendimiento (gen ACTN3) y resultados deportivos, con objetivo de relacionar estos parámetros entre sí en los grupos de edad.

Las nadadoras de mayor edad mostraron tendencia a portar el genotipo heterocigoto RX de ACTN3. En este estudio, la práctica de este deporte podría tener impacto en índice de masa corporal, pliegue tricipital, peso y edad de menarquia. La mayor prevalencia del genotipo heterocigoto ACTN3 R577X podría ofrecer una ventaja, pero el rendimiento en competición de las nadadoras artísticas tuvo poca relación con sus medidas antropométricas.
Interval-Valued and Circular Intuitionistic Fuzzy Present Worth Analyses
Authors: Boltürk Eda , Kahraman Cengiz
Published: March 2022

Present worth (PW) analysis is an important technique in engineering economics for investment analysis. The values of PW analysis parameters such as interest rate, first cost, salvage value and annual cash flow are generally estimated including some degree of uncertainty. In order to capture the vagueness in these parameters, fuzzy sets are often used in the literature. In this study, we introduce interval-valued intuitionistic fuzzy PW analysis and circular intuitionistic fuzzy PW analysis in order to handle the impreciseness in the estimation of PW analysis parameters. Circular intuitionistic fuzzy sets are the latest extension of intuitionistic fuzzy sets defining the uncertainty of membership and non-membership degrees through a circle whose radius is r. Thus, we develop new fuzzy extensions of PW analysis including the uncertainty of membership functions. The methods are given step by step and an application for water treatment device purchasing at a local municipality is illustrated in order to show their applicability. In addition, a multi-parameter sensitivity analysis is given. Finally, discussions and suggestions for future research are given in conclusion section.
FEATURES OF DECOMPOSITION OF MULTI-LEVEL RECTIFIERS UNDER CONDITIONS OF THE SPECIFIC LIMIT OF THE RANGE OF OUTPUT VOLTAGE REGULATION
Authors:   Institute of Electrodynamics National Academy of Science of Ukraine, Pr. Peremohy, 56, Kyiv, 03057, Ukraine, Lypkivskyi K.O. , Mozharovskyi A.G. ,   Institute of Electrodynamics National Academy of Science of Ukraine, Pr. Peremohy, 56, Kyiv, 03057, Ukraine
Published: March 2022

Harmonization of the requirements of certain groups of electrical and electrotechnological consumers of electricity with the current supply conditions requires in many cases the use of converters. Prominent among the systems designed to purposefully change the supply voltage of such consumers (regulation, stabilization) are converters with transformer-and-switches executive structure or tap changing (smart) transformers, which use discrete-time control, in particular so-called multi-level AC rectifiers (MLR). In the synthesis of MLR the main problem is to determine the optimal law of sectioning of the secondary envelope of its transformer. The paper analyzes the features of MLR decomposition into two functionally identical blocks under the given limitation of the output voltage control range and its difference from the decomposition of wide-range MLRs. The a priori variety of circuit technical solutions of such MLRs is determined. New MLRs with high efficiency of semiconductor switch elements use are offered. References 15, figures 7, tables 3.
THE DC-DC CONVERTERS EMI FILTERS CALCULATION METHOD USING LTspіce
Authors:   National Technical University of Ukraine ", Makarenko V.V. ,   Igor Sikorsky Kyiv Polytechnic Institute",   , 37, Peremohy Ave., Kyiv, 03056, Ukraine, Pilinsky V.V. ,   National Technical University of Ukraine "Igor Sikorsky Kyiv Polytechnic Institute", 37, Peremohy Ave., Kyiv, 03056, Ukraine, Gurin V.K. ,   Institute of Electrodynamics National Academy of Science of Ukraine, Pr. Peremohy, 56, Kyiv, 03057, Ukraine
Published: March 2022

The paper proposes a methodology for designing a filter for lowering conductive interference level, generated by pulse voltage converters. Not only the proposed method takes into account the requirements of the standard for electromagnetic compatibility, but also the parameters of the LISN node to measure the level of noise, which are given by a converter to a power supply chain. The articles describes the example of the filter design for a lowering DC-DC converter the noise level of which is in accordance with the standard CSPR25. All stages of design are illustrated by models, they are developed in the LTspice program. Models for analyzing the amplitude-frequency response of a interference filter loaded on a LISN are presented. It is shown that when modeling the operation of pulse sources, it is not advisable to use LISNs with the idealized characteristics of elements. The obtained filter calculations’ results confirm the correctness of the proposed method. References 11, figures 9.