bluuebunny/crossref_metadata_2025 huggingface dataset:
Measuring Women Self-Help Groups and Their Enterprises Sustainability in Odisha
Authors: Rajpal Navin Kumar , Tamang Sharmila
Published: May 2023

The SHG programme has successfully transformed the lives of rural and urban poor by providing financial and non-financial assistance. The effectiveness of the programme is evident from the gradually increasing enrolment. By targeting women as their major priority, the promoting agencies/government is trying to assure the recurrence of the programme. The SHG programme in India has widespread coverage with due effort from NABARD and specialised State agencies with the highest coverage in the southern region. Even the eastern region also holds a significant share with a major presence in West Bengal and Odisha. The present study attempts to examine the sustainability position of WSHGs of Odisha with the help of a multidimensional sustainability index. Two-way analysis was made to evaluate the actual status of SHGs and their enterprises. Initially, the evaluation was done at the SHG level and later enterprise-level analysis was made to conclude the overall sustainability status. Though many studies reported successful implementation and effectiveness of the programme, the actual scenario is quite different. Group-level analysis reveals that financial assistance alone will not break the multi -dimensional poverty. Therefore, the study suggests active participation of government and non-government agencies for developing the required skills.
AI in medicine: recommendations for social and humanitarian expertise
Authors: Bryzgalina E. V. , Gumarova A. N. , Shkomova E. M.
Published: May 2023

The article presents specific recommendations for the examination of AI systems in medicine developed by the authors. The recommendations based on the problems, risks and limitations of the use of AI identified in scientific and philosophical publications of 2019-2022. It is proposed to carry out ethical expertise of projects of medical AI, by analogy with the review of projects of experimental activities in biomedicine; to conduct an ethical review of AI systems at the stage of preparation for their development followed by monitoring the testing of the created system; to focus on bioethical principles during the examination of AI systems for medical purposes.
Interpassivity and psychoanalytic theory: Transformation of the Meaning under Influence of discourse of Authenticity and Ideology Theory
Authors: Kudryashov I. S.
Published: May 2023

The concept of interpassivity plays an important role in understanding the interaction of contemporary human and media; this explains the growth of its usage in the last two decades. However, popularization leads to a transformation in the understanding of this concept or its confusion with others. In our opinion, it is important to preserve the original meaning of this issue. An analysis of the main elements of the concept by R. Pfaller and S. Zizek demonstrates the heuristic value of such “conservatism”, which limits the shift in thematic emphasis. The influence of other concepts (authenticity and alienation) leads to a simplification of the interpassivity, since in this case this concept no longer draws our attention to those aspects that are poorly distinguishable in the optics of humanistic discourse and social criticism. On the contrary, the preservation of the original interpretation makes it possible to include issues of pleasure, unconscious fantasies and beliefs in the consideration of a number of problems of human relations with contemporary media.
A importância do médico no acolhimento ao cuidado da saúde da mulher na estratégia de saúde da família
Authors: Brito Élyta Palloma Rodrigues , Sousa Milena Nunes Alves de
Published: May 2023

Objetivo: Evidenciar o acolhimento e cuidado à saúde da mulher na estratégia de saúde da família (ESF), na cidade de Patos, localizada no sertão paraibano, uma vez que o profissional médico deve ser capaz de identificar e oportunizar momentos educativos, facilitando o diagnóstico e o tratamento adequado que culmine com a prevenção e promoção da saúde. Métodos: A pesquisa foi realizada pela residente em medicina de família e comunidade, atuante de uma ESF da cidade de Patos, localizada no sertão paraibano. Para a amostra, foi sorteado aleatoriamente 1 médico de cada unidade básica de saúde (UBS) situada nos principais bairros de Patos - PB, totalizando dez participantes. Foram incluídos no estudo médicos que atuavam na ESF do mesmo município e como critério de exclusão, não estar exercendo a função assistencial nas equipes Saúde da Família no âmbito da saúde da mulher. Resultados: Os dados foram coletados entre os meses de agosto e setembro de 2022. As análises dos dados foram feitas pelo Microsoft Excel e o Statistical Package for the Social Sciences (SPSS). Foi adotada a análise descritiva simples e inferencial. Conclusão: O presente estudo pode auxiliar na prática clínica, bem como no estabelecimento de intervenções preventivas e de promoção da saúde do grupo.
Cerclagem cervical como moduladora da idade gestacional ao parto em gestantes com insuficiência istmo-cervical
Authors: Reis Amanda Lílice Valle , Ferreira Ana Elisa de Castro , Misaka Isabela Mika de Oliveira , Fonseca Jaqueline Maria Rezende da , Araújo Rafaela Aparecida Corrêa Monjardim , Menezes Samara Oliveira de , Damianse Laura Alcântara , Talma Sofia Machado , Menão Tauane Larissa , Zimmermmann Juliana Barroso
Published: May 2023

Objetivo: Avaliar a cerclagem cervical como moduladora da idade gestacional no parto. Métodos: Tratou-se de uma coorte histórica onde foram estudadas 93 gestantes, sendo 43 com IIC e cercladas pela técnica de Mac Donald e 50 gestantes do baixo risco obstétrico. O presente estudo foi aprovado pelo Comitê de Ética e Pesquisa da Faculdade de Medicina de Barbacena. Resultados: A média de idade das pacientes foi de 29,40 + 7,1 e as médias de gestações, partos e abortos foram respectivamente de 2,54 +1,91, 0,79 +1,22 e 0,77+ 1,2, entretanto, quando se comparou os grupos identificou-se que as gestantes com maior número de gestações (p<0,001), partos (p<0,001) e abortos (p<0,001) eram aquelas que tinham IIC. A cerclagem foi realizada com média de 12,50 + 0,93 semanas, mas a idade gestacional ao parto foi menor quando comparadas com as gestantes de baixo risco obstétrico (37,50 + 1,62 x 38,40 + 19,5; p=0,03). Conclusão: Apesar das pacientes cercladas apresentarem média de idade gestacional menor quando comparadas com as gestantes de baixo risco, a média dessa idade gestacional está dentro da faixa de feto a termo, o que demonstra que a cerclagem modula positivamente a idade gestacional no parto em gestantes com IIC.
Integração ensino-serviço e seus impactos na qualidade da formação profissional da Enfermagem
Authors: Rosa João Victor Moura , Lopes Márcia Maria Bragança , Pamplona Monica Custódia de Coutro Abreu , Polaro Sandra Helena Isse , Beckes Vania Marli Schubert , Sousa Ianny Ferreira Raiol , Silva Ingrid Fabiane Santos da , Nova Pedro Vitor Rocha Vila , Candido Arielly de Azevedo , Martinez Leonardo de Paula Vieira
Published: May 2023

Objetivo: Evidenciar a importância da integração ensino-serviço e seus impactos na qualidade da formação profissional do acadêmico de enfermagem. Métodos: Estudo de caráter explanatório, qualitativo, do tipo estudo de caso, realizado no município de Belém, estado do Pará-Brasil, e teve como contexto o Projeto Multicampi Saúde/2019. A população amostral do estudo foi composta de quatro enfermeiras (os) e 11 alunos (os), totalizando 15 participantes. A coleta de dados ocorreu no período de 04 de janeiro 2021 a 26 de fevereiro de 2021, e os dados obtidos foram conduzidos por meio de entrevista focada, seguida de análise baseada na Teoria Fundamentada nos Dados (TFD). A codificação dos dados foi realizada pela Codificação Aberta e Codificação Axial. A pesquisa foi aprovada pelo Comitê de Ética em Pesquisa. Resultados: Evidenciaram-se quatro categorias, a saber: Integração Ensino-Serviço e seus impactos na qualidade da formação; Ação dos programas indutores de Integração Ensino-Serviço; Exercício da integração multiprofissional e Prática do cuidado interprofissional. Considerações finais: Conclui-se que o Projeto Multicampi Saúde, como integrador ensino-serviço, oportunizou a aprendizagem significativa e o reconhecimento da importância do processo de formação dos profissionais enfermeiros.
Avaliação da via obstétrica no Brasil segundo a classificação de Robson nos últimos 5 anos
Authors: Carvalho Isabela Ávila Fontes , Almeida Berila Beatriz Dias de , Vasconcelos Guilherme Barreto , Lima Maria Adriely Cunha , Pires Luciana Barros Melo
Published: May 2023

Objetivo: Avaliar a prevalência dos tipos de parto no Brasil entre 2018 e 2022, com ênfase na distribuição de acordo com os Grupos de Robson. Métodos: Trata-se de um estudo epidemiológico realizado através dos dados disponibilizados pelo Painel de Monitoramento de Nascidos Vivos segundo Classificação de Risco Epidemiológico. Os resultados coletados foram armazenados e tabulados no Microsoft Office Excel®, sendo apresentados em frequência absoluta e relativa. Resultados: Foram avaliados 13.667.735 nascidos-vivos, sendo que 56,9% dos partos foram cesáreas. Os Grupos 9, 6 e 7 apresentaram as maiores taxas de cesáreas, contudo, os que mais contribuíram para a taxa total foram os Grupos 5 (35,43%), 2 (17,15%) e 1 (13,47%). Ressalta-se que o parto cesáreo foi o mais prevalente em 7 Grupos de Robson, excluindo apenas o 1, 3 e 4. Conclusão: Observou-se uma alta taxa de cesáreas no período analisado, sendo que o Grupo 5 foi o que mais contribuiu para isso, assim como os Grupos 1 e 2, sendo que esses grupos são passíveis de intervenções para redução da taxa de cesarianas, de forma que seja possível alcançar uma menor morbimortalidade materna e perinatal concomitantemente.
Using virtual lines of navigation for a successful transcortical approach
Authors: Omura Naoki , Kawabata Shinji , Yoshimura Kohei , Yagi Ryokichi , Furuse Motomasa , Wanibuchi Masahiko
Published: May 2023

Background:

Neuronavigation systems have become essential tools in image-guided neurosurgery that aid in the accurate resection of brain tumors. Recent advancements to these devices can indicate the precise location of lesions but can also project an augmented reality (AR) image on the microscope eyepiece to facilitate a successful surgical operation. Although the transcortical approach is a very popular method in neurosurgery, it can lead to disorientation and can cause unnecessary brain damage when the distance from the brain surface to the lesion is long. Herein, we report on an actual case in which a virtual line from AR images was used to assist the transcortical approach.

Methods:

A virtual line connecting the entry point and the target point, which were set as the navigation route, was created using Stealth station S7® (Medtronic, Minneapolis, USA). This line was projected as an AR image on the microscope eyepiece. It was possible to reach the target point by proceeding through the white matter along the displayed virtual line.

Results:

The lesion was reached within a short duration using virtual line without disorientation.

Conclusion:

Setting a virtual line as an AR image using neuronavigation is a simple and accurate method that can effectively support the conventional transcortical approach.
Clinical efficacy of anti-VEGF therapy in treatment of diabetic macular edema in eyes with vitreous loss
Authors:   The Far Eastern State Medical University, Khabarovsk, Russian Federation, Pomytkina N.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk, Russian Federation, Lebedev Y.B. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk, Russian Federation, Sorokin E.L. ,   The Far Eastern State Medical University, Khabarovsk, Russian Federation,   The S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk, Russian Federation, Pshenichnov M.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk, Russian Federation, Pashentsev Y.E. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk, Russian Federation
Published: May 2023

Purpose. To analyze clinical efficacy of anti-VEGF therapy for diabetic macular edema (DME) in eyes with vitreous loss. Material and methods. 34 patients (38 eyes) with vitreous loss and DME were examined: on the background of pre-proliferative diabetic retinopathy (PPDR) (18 eyes) and proliferative diabetic retinopathy (PDR) (20 eyes) (the main group). The comparison group consisted of 40 patients (40 eyes) with native vitreous body and DME on the background of PPDR (20 eyes) and PDR (20 eyes). Intravitreal injection of Lucentis 0.5 mg (IVIL) was carried out according to scheme «three monthly injections», then — to scheme «on demand». Results. Complete regression of DME in eyes with vitreous loss occurred in 74 % of cases; in eyes with native vitreous body — in 75 %. The duration of postoperative reaction in eyes with vitreous loss was up to 10–14 days, compared with 1–3 days in eyes with native vitreous body. The results of the study revealed, that number of IVIL was significantly less in patients with DME on the background of PPDR, than with PDR. Conclusions. The presence of local neuroepithelial detachment on the background of diffuse DME is prognostically favorable factor for anti-VEGF therapy. The effectiveness of IVIL in treatment of DME is comparable in eyes with native vitreous body and vitreous loss. Keywords: diabetes mellitus, diabetic macular edema, pre-proliferative diabetic retinopathy, proliferative diabetic retinopathy, vitreous loss, Lucentis intravitreal injection
Lenticular surgery — SMILE after anterior lamellar keratoplasty
Authors:   Ufa Eye Research Institute, Usubov E.L. , Bikbulatov R.M. ,   Clinic of eye diseases, Ufa, Miniazeva L.A. ,   Ufa Eye Research Institute
Published: May 2023

Relex Smile technology is an innovative method of laser correction of myopia and myopic astigmatism, minimally affecting the biomechanical properties of the cornea. This technique does not require cutting out a corneal flap and allows to remove the laser-formed corneal lenticule through a small incision. Ametropias, and especially high simple or complex myopic astigmatism, are the most frequent refractive complications after various types of keratoplasty (KP), which significantly reduce the visual acuity and the quality of life in patients, especially when refractive errors cannot be corrected by glasses or contact lenses due to their intolerance or due to anisometropia. Purpose. To evaluate the effectiveness of the residual ametropia correction with SMILE after anterior lamellar keratoplasty (ALK) in a patient with secondary keratectasia. Material and methods. A patient, 30, with complaints of low vision in the left eye. The patient has been noticing a decrease in vision since the age of 18, suffers from myopia. Anamnesis: photorefractive keratectomy and accelerated corneal crosslinking in both eyes. ALK was performed in the left eye. The patient underwent microinvasive femtolaser-assisted extraction of the corneal lenticula using the Relex Smile technique. UCVA and autorefraction data were evaluated 1 week, 1 month and 3 months after surgery. Results. On the first day after the Relex Smile procedure, uncorrected visual acuity (UCVA) was 0.3. 3 months after the operation, UCVA was 0.9 in the left eye. The postoperative spherical equivalent and visual acuity were stable during the 12-month dynamic follow-up, UCVA was 0.9, refractive indices sph –0.5D cyl –0.75D ax 82°, residual corneal thickness 580 microns. Conclusion. Intrastromal extraction of corneal lenticula — Relex Smile -is an alternative, effective, safe and stable technique of induced ametropia correction after deep anterior lamellar keratoplasty. Keywords: Relex Smile, anterior lamellar keratoplasty, induced ametropia, keratectasia
Reminiscence of the Image-Paradigm of the Priesthood of the Virgin in Himnography of the Great Vespers of the Nativity of the Mother of God
Authors: Жуковская И.И.
Published: May 2023

Празднование Рождества Богородицы, возникшее в начале VI века в греческой Церкви, широко распространилось в христианском мире. Образ Богоматери связывался в латинском и византийском течениях христианства с церковью и литургией, что обусловило появление парадигмы «Богоматерь-священник». В Византии Священство Богородицы стало символически емким и укорененным в традиции понятием, нашедшем отражение в иеротопии — особом творчестве, результатом которого было формирование сакрального пространства праздничного богослужения. Чинопоследование Рождества Богородицы сложилось как высокохудожественное, совершенное по структуре и драматургии священнодействие. Музыкально-поэтические тексты чина обнаруживаются в Стихирарях, Ирмологионах и книге Праздники, созданных в религиозно-культурных центрах Восточной Европы — Великом Княжестве Литовском и Московской Руси. В исследовании поставлена цель охарактеризовать образ Богородицы в списках песнопения «Денесе иже на разуменыихо престолехо» великой вечерни Рождества Богородицы конца XVI–XVIII вв. как реминисценции образа-парадигмы византийской иконографии «Священство Богоматери». Творчество белорусско-украинских и московских мастеров показывает многогранность и подвижность его отражений. В двух певческих традициях сформировались устойчивые и самостоятельные модели-отзвуки образа-парадигмы. Оригинальные композиции обнаруживают неповторимую и разнообразную корреляцию музыкальной лексики и поэтического текста.

Celebration of the Saint Virgin’s Birth, which started in the early 6th century in the Greek Church, widespread in the Christian world. The image of the Mother of God was associated in Latin and Byzantine currents of Christianity with the church and the liturgy, which determined appearance of the Saint Virgin-priest paradigm. In  Byzantium the  Priesthood of the Saint Virgin became a symbolic notion, which was reflected in hierotopy — a specific art implying formation of the sacred space of festive worship. The Nativity of Virgin Mary developed in a highly artistic and perfectly structured and dramatized service. Musical and poetic texts of  the chant can be found in Verses, Irmologions and the Book of Prazdniki (Feasts), created in the religious and cultural centers of Eastern Europe — the Grand Duchy of Lithuania and Moscow Rus. The aim of the study is to characterize the image of the Mother of God in the lists of the chant “Now in heaven thrones” of the great Vespers of the Nativity of Virgin Mary at the end of the XVI–XVIIIth centuries, as a reminiscence of the image-paradigm of the Byzantine iconography “The Priesthood of the Saint Virgin”. The work of the Belarusian-Ukrainian and Moscow masters shows the versatility and mobility of its reflections. The two liturgical traditions formed stable and independent models-reflections of the image-paradigm. The form of the original compositions of the chant reveal a unique and diverse correlation between the musical vocabulary and the poetic text.
Auditory Gesture in the Liturgical Space of the Temple
Authors: Чудинова И.А.
Published: May 2023

На основании важнейших положений византийского богословия и данных византийских и славянских церковных Типиконов рассматривается принцип соотношения аудиальной жестовости и литургической топики храма. Приводятся свидетельства греческой и славянской литургической письменности, подтверждающие особую значимость для православной традиции связи произносимого литургического слова с аудиальным пространством храма. Принципиально важны расположение источника звука и место его слухового восприятия — место стояния и перемещения молящихся, возглашающих и поющих, так же как и тех идиофонов, которые употребляются в соответствии с обычаем и звучание которых «вплетено» в аудиальную ткань богослужения. Уставные указания определяют значение расстояния, а также пространственной ориентации при произнесении слова. Своеобразие аудиальной атмосферы придает каждому храму особый «голос», который находится в согласии со всеми другими православными храмами. Многообразие составляющих аудиально-жестовой системы богослужения подчинено базисной идее, выражаемой всем пространством храма, идеей креста и круга, круговым движением, концентрирующим внимание и направляющим к восприятию церковных Таинств. Для современного человека характерна внутренняя разорванность, отъединенность, расщепленность, которая прослеживается во всех проявлениях человеческого бытия. Выход из подобного состояния дан Божественной Литургией, силой, единящей человека с самим собой и с Богом.

The article considers the principle of correlation between auditory gestures and the liturgical space of the temple based on the most important provisions of Byzantine theology and the data of Byzantine and Slavic church Typicons, and gives evidence of Greek and Slavic liturgical writing, confirming special significance of the connection between the spoken liturgical word and the auditory space of the church for the Orthodox tradition. What matters is the location of the sound source and the place of its auditory perception — the place of standing and moving of those praying, proclaiming and singing, as well as those idiophones that are used in accordance with the custom and whose sound is “woven” into the auditory fabric of the worship. Statutory indications determine importance of distance, as well as spatial orientation when pronouncing a word. Due to the originality of the auditory atmosphere, each temple has its own special “voice”, which is in harmony with all other Orthodox churches. The diversity of the components of the auditory-gestural system of worship is subject to the basic idea expressed by the entire space of the temple, the idea of the cross and circle, a circular movement that focuses attention and directs to the perception of the Church Sacraments. Modern man is characterized by internal fragmentation, isolation, splitting, which can be traced in all manifestations of human existence. The way out of this state is given by the Divine Liturgy, the power that unites man with himself and with God.
Electrolytic cement clinker production sustained through orthogonalization of ion vectors
Authors: Zhang Zishuai , Mowbray Benjamin , Parkyn Colin , Kim Yongwook , Berlinguette Curtis
Published: May 2023

Electrochemical reactors can reduce the carbon intensity of cement production by using electricity to convert limestone (CaCO3) into Ca(OH)2, which can then be combined with silica (SiO2) at high temperatures to produce cement clinker. A key challenge with this method is the deposition of solid Ca(OH)2 at the reactor membrane leads to unacceptably low energy efficiencies. To address this challenge, we connected the electrochemical reactor (“cement electrolyser”) to a distinctive chemical reactor (“calcium reactor”) so that Ca(OH)2 could form there instead, and not within the electrochemical reactor. In this tandem system, the cement electrolyser generated H+ and OH– in the respective chemical and cathode compartments. The H+ then reacted with CaCO3 to form Ca2+ ions, which were diverted into the calcium reactor to react with the OH– to form Ca(OH)2. We fabricated a composite membrane to selectively block the transport of Ca2+ into the cathode compartment. Charge balance in the cement reactor was enabled with monovalent ions (e.g., K+) as the positive charge carrier. This orthgonalized ion management was validated by operando imaging. The tandem reactor enabled the electrolysis process to operate for 50 hours at 100 mA cm-2 without any voltage increase, which represents a meaningful step forward for cement clinker precursor production.
Exploring Bipolar Membranes for Electrochemical Carbon Capture
Authors: Bui Justin C. , Lucas Éowyn , Lees Eric W. , Liu Andrew K. , Atwater Harry A. , Xiang Chengxiang , Bell Alexis T. , Weber Adam Z.
Published: May 2023

Carbon dioxide (CO2) must be removed from the atmosphere to mitigate the negative effects of climate change. However, the most scalable methods for removing CO2 from the air require heat from fossil-fuel combustion to produce pure CO2 and continuously regenerate the sorbent. Bipolar-membrane electrodialysis (BPM-ED) is a promising technology that uses renewable electricity to dissociate water into acid and base to regenerate bicarbonate-based CO2 capture solutions, such as those used in chemical loops of direct-air-capture (DAC) processes, and also in direct-ocean capture (DOC) to promote atmospheric CO2 drawdown via decarbonization of the shallow ocean. However, a lack of understanding of the mechanisms of reactive carbon species transport in BPMs has precluded industrial-scale deployment of BPM-ED. In this study, we develop an experimentally-validated 1D model for the electrochemical regeneration of CO2 from bicarbonate-based carbon capture solutions and seawater using BPM-ED. Our experimental and computational results demonstrate that out-of-equilibrium buffer reactions within the BPM drive the formation of CO2 at the BPM/electrolyte interface with energy-intensities of less than 150 kJ mol-1. However, high rates of bubble formation increase the energy intensity of CO2 recovery at current densities >100 mA cm−2. Sensitivity analyses show that optimizing the BPM and bubble removal could enable CO2 recovery from bicarbonate solutions at energy intensities <100 kJ mol−1 and current densities >100 mA cm−2. These results provide design principles for industrial-scale CO2 recovery using BPM-ED.
A novel “activation switch” motif common to all aminergic receptors
Authors: Lee Kuo Hao , Manning Jamie , Javitch Jonathan , Shi Lei
Published: May 2023

Aminergic receptors are G protein-coupled receptors (GPCRs) that transduce signals from small endogenous biogenic amines to regulate intracellular signaling pathways. Agonist binding in the ligand binding pocket on the extracellular side opens and prepares a cavity on the intracellular face of the receptors to interact with and activate G proteins and β-arrestins. Here, by reviewing and analyzing all available aminergic receptor structures, we seek to identify activation-related conformational changes that are independent of the specific scaffold of bound agonist, which we define as “activation conformational changes” (ACCs). While some common intracellular ACCs have been well-documented, identifying common extracellular ACCs, including those in the ligand binding pocket, is complicated by local adjustments to different ligand scaffolds. Our analysis shows no common ACCs at the extracellular ends of the transmembrane helices. Furthermore, the restricted access to the ligand binding pocket identified previously in some receptors is not universal. Notably, the Trp6.48 toggle switch and the Pro5.50-Ile3.40-Phe6.44 (PIF) motif at the bottom of the ligand binding pocket have previously been proposed to mediate the conformational consequences of ligand binding to the intracellular side of the receptors. Our analysis shows that common ACCs in the ligand binding pocket are associated with the PIF motif and nearby residues, including Trp6.48, but fails to support a shared rotamer toggle associated with activation. However, we identify two common rearrangements between the extracellular and middle subsegments, and propose a novel “activation switch” motif common to all aminergic receptors. This motif includes the middle subsegments of transmembrane helices 3, 5, and 6, and integrates both the PIF motif and Trp6.48.
Direct Mechanocatalysis without Milling Media – From Mixer Mills to Resonant Accoustic Mixers
Authors: Wohlgemuth Maximilian , Schmidt Sarah , Mayer Maike , Pickhardt Wilm , Graetz Sven , Borchardt Lars
Published: May 2023

Here we describe the development of a sustainable and cost-effective approach for catalytic cross-coupling reactions in mechanochemistry. It is found that the substrate's impact with the vessel wall alone is sufficient to initiate the reaction, indicating that milling balls primarily serve as mixing agents rather than energy carriers. The absence of milling balls can be offset by adjusting the rheology using liquid-assisted grinding (LAG). The η-sweet spot of 0.25 μl/mg is confirmed for both resonance acoustic mixer (RAM) and ball-free mixer mills and is higher than in the presence of milling balls. The RAM exhibits excellent performance in the Suzuki reaction, achieving yields of 90% after 60 minutes and complete conversion after 90 minutes. The longevity of the milling vessel is significantly improved in the RAM, allowing for at least 20 reactions without deterioration.
AutoDock-SS: AutoDock for Multiconformational Ligand-based Virtual Screening
Authors: Ni Boyang , Wang Haoying , Khalaf Huda , Blay-Roger Vincent , Houston Douglas R
Published: May 2023

Ligand-based virtual screening (LBVS) is widely employed in drug discovery to identify potential leads when the crystallographic structure of the target protein remains unknown. In this study, we introduce a novel three-dimensional LBVS workflow incorporating newly designed ligand-based grid maps and AutoDock-GPU, referred to as AutoDock-SS (Similarity Searching). AutoDock-SS features two modes supporting either single query ligands or multiple pre-aligned ligands as input. The virtual screening performance of AutoDock-SS single-reference mode was evaluated using the standard Directory of Useful Decoys – Enhanced (DUD-E) dataset, with the method outperforming alternative state-of-the-art 3D LBVS methods. The mean area under the receiver operating characteristics curve (AUC) reached 0.775 (exceeding the maximum of 0.755 for alternative methods), and the enrichment factor at one percentage (EF1%) was 25.72. AutoDock-SS multi-reference mode was assessed on the augmented DUD-E dataset (DUD-E+) using five pre-aligned query ligands, displaying statistically significant superior prediction accuracy (mean AUC of 0.843, p < 10-5) and higher mean EF1% (34.59) compared to the singe-reference mode. Overall, the findings suggested that AutoDock-SS exhibits enhanced binding conformation prediction when screening the original DUD-E dataset. The proposed method accounts for the shape, pharmacophore, and electrostatic potential of the query ligand(s) to improve prediction accuracy and includes a built-in conformational sampling algorithm that natively considers compounds as naturally conformationally flexible—an aspect not present in existing LBVS methods.
Hubungan Rasionalitas Penggunaan Antibiotik terhadap Luaran Klinis Pasien Pneumonia Komunitas Rawat Inap
Authors: Widiyastuti Asih , Kumala Shirly , Utami R Hesty , Pratama Anton
Published: May 2023

Pneumonia is a lung parenchyma disease caused by bacteria, fungi, viruses, and parasites. Irrational use of antibiotics will lead to antibiotic resistance, so the goal of therapy has yet to be achieved. This study evaluates the rationality of using community antibiotics for the clinical outcome of community pneumonia patients in RSUD. Dr. H. Abdul Moeloek.This research is descriptive-analytic with a cross-sectional design and retrospective data retrieval from medical records in 2019. The data analysis was carried out descriptively, and the correlation analysis of the rationale of antibiotic use with clinical outcomes using the Spearman test. The study's results of 144 analyzed showed the characteristics of community pneumonia patients, 78 male, and 66 female patients. The evaluation of the use of antibiotics using the ATC/DDD method showed that Ceftriaxon DDD was 46.80 DDD/100 patient-days, Azithromycin (23.91 DDD/100 patient-days), Levofloxacin (22.70 DDD/100 patient-days). With the Gyssen method, patients used antibiotics correctly (category 0) by 72.91% and incorrectly (categories I – VI) by 27.09%. Statistical analysis showed a significant relationship (p-value=0.003) between the rational use of antibiotics and patient clinical outcomes. Further research is needed regarding the incidence of Drugs Related Problems on the clinical effects of community pneumonia patients.
Coping and Stress Management Training as an Effort to Improve Stress Adaption Ability
Authors: Zakiyah Ana , Rofi'ah Ika Ainur
Published: May 2023

Each interacts with the environment and gives a different response, namely a positive response and even a negative response because he considers that changing conditions is a pressure that causes stress and encourages individuals to respond to coping. The research objective was to determine the effectiveness of coping and stress management training in increasing the perception of stress in health levels before and after the intervention was given. The design used one group pre-post design. The population was 30 health cadres, and the sampling technique used total sampling. Before the activity, the respondents were given a questionnaire to determine stress levels, followed by training. The respondents applied stress management techniques within one month, after which a post-test was carried out. The instrument used the Perceived Stress Scale. The results showed that the mean stress adaptation of respondents before the intervention was 20.73, and the mean stress adaptation after the intervention was 7.83. Further analysis using a paired t-test showed a significant difference in stress adaptation between stress adaptations to health cadres before and after the intervention (p-value=0.001; α
Periodic solutions of nonlinear finite difference systems with time delays
Authors: S.B. Kiwne
Published: May 2023

In this paper a coupled system of nonlinear finite difference equations corresponding to a class of periodic-parabolic systems with time delays and with nonlinear boundary conditions in a bounded domain is investigated. Using the method of upper-lower solutions two monotone sequences for the finite difference system are constructed. Existence of maximal and minimal periodic solutions of coupled system of finite difference equations with nonlinear boundary conditions is also discussed. The proof of existence theorem is based on the method of upper-lower solutions and its associated monotone iterations. It is shown that the sequence of iterations converges monotonically to unique solution of the nonlinear finite difference system with time delays under consideration.
On $\widetilde{g}_\alpha$ -sets in bitopological spaces
Authors: M. Lellis Thivagar  , Nirmala Rebecca Paul
Published: May 2023

The paper introduces $\widetilde{g}_\alpha$-closed sets in bitopological spaces and establishes the relationship between other existing sets. As an application $(i, j) \widetilde{g}_\alpha$-closure is introduced to define a new topology. We also derive a new decomposition of continuity.
Generalization for character formulas in terms of continued fraction identities
Authors: M.P. Chaudhary
Published: May 2023

In recent work, Folsom discussed character formulas for classical mock theta functions of Ramanujan. Here, we suggest representations for character formulas in terms of continued fraction identities or in more precise language, we can say an applications of continued fraction identities to character formulas. As a consequence, we obtain fourteen new results.
Common fixed points for a class of multi-valued mappings and application to functional equations arising in dynamic programming
Authors: A. Aghajani  , E. Pourhadi
Published: May 2023

In this paper, we give an existence theorem for hybrid generalized multi-valued α-contractive type mappings which extends, improves and unifies the corresponding main result of Sintunavart and Kumam [W. Sintunavart, P. Kumam, Common fixed point theorem for hybrid generalized multi-valued contraction mappings, Appl. Math. Lett. 25 (2012), 52-57] and some main results in the literature. As an application, we give some existence and uniqueness results for solutions of a certain class of functional equations arising in dynamic programming to illustrate the efficiency and usefulness of our main result.
Invariant solutions of Barlett and Whitaker’s equations
Authors: Mehdi Nadjafikhah  , Omid Chekini
Published: May 2023

Lie symmetry group method is applied to study the Barlett and Whitaker’s equations. The symmetry group and its optimal system are given,and group invariant solutions associated to the symmetries are obtained. Finally the structure of the Lie algebra symmetries is determined.
O Quiz Interativo Digital na identificação de dificuldades de aprendizagem em conceitos nucleares do Cálculo I
Authors: Anjos Isabela Matias dos , Martins Eder Marinho , Reis Frederico da Silva
Published: May 2023

Este artigo apresenta uma pesquisa que objetivou identificar as dificuldades de aprendizagem em Cálculo I evidenciadas pelo Quiz Interativo Digital (QID). A metodologia de pesquisa qualitativa contemplou uma pesquisa com alunos de Licenciatura e de Bacharelado em Matemática da Universidade Federal de Ouro Preto. O QID foi desenvolvido em um ambiente de programação visual e aplicado por meio dos celulares dos alunos em 3 etapas: Limites e Continuidade; Derivadas; Integrais. Os resultados apontam que uma grande parte das dificuldades podem ser associadas às dificuldades relacionadas a conteúdos da Educação Básica, especialmente, no caso de limites e continuidade. Outra parte bastante significativa das dificuldades recai sobre as aplicações matemáticas, especialmente, no caso de derivadas e integrais. Nas conclusões, ressaltamos a importância de um ensino de Cálculo I focado não somente na aplicação de regras, mas que também privilegie a interpretação, a representação e a aplicação dos conceitos nucleares do Cálculo I.
Analisis Hasil Belajar Passing Bawah Dalam Permainan Bolavoli Pada Siswa SMP Negeri 1 Pinrang Kelas VIII
Authors: Sutriawan Agus Agus
Published: May 2023

This study aims to determine the learning outcomes of underpassing in volleyball games for students of SMP Negeri 1 Pinrang class VIII. This type of research is a type of descriptive research. The population in this study were all male students of class VIII SMP Negeri 1 Pinrang with a total population of 75 students with the sample used was 26 students with a sampling technique using random sampling or a random system of 35%. The research instrument used is descriptive analysis, normality analysis, and categorization with 95% truth level with the help of SPSS version 20.00 application. The results showed that: The learning outcomes of passing down in volleyball games for students of SMP Negeri 1 Pinrang in class VIII were in the Medium category or 34.6%.
UPAYA GURU PENDIDIKAN JASMANI SMP NEGERI SE-KABUPATEN SIDRAP DALAM PEMBELAJARAN DARING DI MASA PANDEMI COVID-19
Authors: Irvan Irvan , Hanafi Suriah , Sufitriyono Sufitriyono , Asyhari Hasbi
Published: May 2023

Penelitian ini bertujuan untuk mengetahui upaya guru pendidikan jasmani SMP Negeri Se-Kabupaten Sidrap dalam menerapkan proses pembelajaran di masa pandemi Covid-19. Jenis penelitian ini adalah penelitian deskriptif kuantitatif dengan pendekatan one shot case study dengan satu kali pengumpulan data. Metode yang digunakan dalam penelitian ini adalah metode survey sedangkan pengumpulan datanya menggunakan kuesioner.Hasil dari penelitian ini menunjukkan bahwa upaya guru pendidikan jasmani SMA Negeri se-Kabupaten Sidrap dalam menerapkan proses pembelajaran di masa pandemi covid-19 dijabarkan dalam 8 indikator yaitu: 80% guru penjas memiliki pemahaman terhadap karakteristik anak didiknya, 83,33% guru penjas memiliki kemampuan memberikan bimbingan untuk menumbuhkan potensi dan keterampilan motorik anak didik dalam proses pembelajaran penjas, 100% guru penjas memiliki kemampuan dalam melaksanakan pembelajaran penjas dimasa pandemi Covid-19, 65% guru penjas mengalami hambatan dalam menerapkan proses pembelajaran penjas dimasa pandemi Covid-19, 100%  guru penjas telah memiliki pemahaman tentang penerapan pembelajaran di rumah sesuai arahan Kemendikbud, 100% guru penjas memiliki kemampuan memanfaatkan media pembelajaran online seperti watsapp, Microsoft teams, zoom dan sebagainya, 100% guru penjas memiliki persepsi yang sama tentang proses belajar-mengajar di rumah, dan 77,78% guru penjas memahami terhadap kendala yang dialami peserta didik dalam proses pembelajaran penjas di rumah.
SÍTIOS ARQUEOLÓGICOS: DANOS NATURAIS E ANTRÓPICOS
Authors: Helena Rufino Elenita
Published: May 2023

A despeito da existência de normas dirigidas à preservação e conservação de bens culturais desde a década de 1930, orientadas por diretrizes internacionais das quais o Brasil é país signatário e mesmo a vigência de lei nacional publicada na década de 1960 que assegura a salvaguarda de sítios arqueológicos, ainda assim o enfrentamento permanente de danos que impactam os sítios é uma constante preocupação de pesquisadores, estudantes e gestores. Este trabalho seleciona três tipos de agressões observáveis nos sítios rupestres pernambucanos, a partir da identificação de seus agentes causadores: os naturais, os causados por pessoa física e provocados por pessoa jurídica, identificando suas respetivas características, motivações e responsabilidades, finaliza sugerindo a possibilidade de reparação onde os valores simbólicos atribuídos tenham pertinência ante a condição não renovável dos sítios arqueológicos.
ENTRE O NORMAL E O PATOLÓGICO: CONSIDERAÇÕES TEÓRICAS SOBRE ENVELHECIMENTO E DOENÇA NA PERSPECTIVA DA OSTEOARQUEOLOGIA
Authors: Barbosa Paiva Nascimento Desirée , Roldan Mastrorosa Raquel , Francisco Serafim Monteiro da Silva Sérgio
Published: May 2023

O envelhecimento humano é um fenômeno complexo e deletério, podendo ser compreendido através de concepções biológicas, cronológicas e culturais. Considerando as pluralidades que envolvem as conceitualizações e classificações sobre o normal e o patológico nas áreas das ciências médicas e sociais, identificamos uma carência de estudos relacionados à revisão conceitual e classificatória na Arqueologia, principalmente dos processos naturais de envelhecimento e elaboração do perfil biológico dos envelhecidos. Objetiva-se revisitar algumas discussões sobre doenças e envelhecimento, tanto no âmbito fisiológico, quanto no cultural, contrapondo com as classificações e patologias descritas nos manuais de osteoarqueologia. Foram analisadas algumas condições patológicas e ontogênicas, suas definições no que tange às doenças relacionadas ao envelhecimento. Algumas patologias estão relacionadas diretamente aos processos degenerativos do envelhecimento. As normatividades classificatórias interferem nas interpretações arqueológicas, por considerarmos que algumas alterações, quando associadas a indivíduos envelhecidos, não devem ser classificadas como patologias, mas como processos naturais de senescência.
Model Pembelajaran Problem Possing melalui Pembelajaran Daring Zoom untuk Mengajarkan “Peluang Suatu Kejadian” pada Siswa Kelas XII Sman 1 Kademangan Kabupaten Blitar
Authors: Tumojo Bambang
Published: May 2023

This study took the initiative to apply a learning model that combines cooperative learning, requires high reasoning power and utilizes communication technology that is packaged in the form of CAR using a problem possing learning model through online learning zoom. This research was conducted at SMAN 1 KADEMANGAN in the even semester of 2020/2021. The results of this study indicate that the learning process with a problem possing model through online zoom learning can increase creativity and train students to have high discipline, responsibility, and can train students to think at high levels (high order thinking) and train verbal skills because they are trained to present the result of their work. This learning model can also motivate students to take advantage of technological facilities (laptops and cellphones) with a zoom application in the learning process, so that students are accustomed to using technology.
Pengaruh Kualitas Pelayanan Jasa Terhadap Kepuasan Para Nasabah Di BMT Kabupaten Blitar
Authors: Yusuf Saifudin , Rohmah Aninatur , Rudita Devina Dea
Published: May 2023

Penelitian ini bertujuan untuk mengetahui (1) Apakah ada pengaruh signifikan kualitas pelayanan? yang terdiri dari berwujud, keandalan, daya tanggap, jaminan, dan empati terhadap kepuasan pelanggan.2) Faktor dimensi kualitas pelayanan yang paling dominan. Hasil penelitian menunjukkan bahwa: (1) Ada pengaruh yang signifikan pengaruh kualitas pelayanan yang terdiri dari tangible, reliability, daya tanggap, jaminan, dan empati terhadap kepuasan pelanggan. Ini terbukti dari hasil analisis regresi diperoleh nilai F-hitung > F-tabel (30.744 > 2.45) pada taraf signifikansi 5%. Itu memberikan bukti pada pelayanan, kehandalan personel dalam memberikan pelayanan, ketepatan dalam genggaman petugas menanggapi keluhan pelanggan, memberikan jaminan pelayanan, dan memberikan perhatian pada keluhan pelanggan menyebabkan perhatian pelanggan dan loyalitas kepada perusahaan, 2) Dimensi keandalan adalah dimensi yang memberikan pengaruh dominan terhadap kepuasan pelanggan. Hal itu dapat dilihat dari hitung nilai t-hitung dimensi keandalan (4,004) lebih tinggi dari yang lain dimensi t-hitung berwujud (3.106), daya tanggap 3.779), jaminan (2,614), dan empati (3.188). Artinya jika kehandalan dalam memberikan pelayanan menyebabkan pelanggan merasa puas.
Peran dan Periodisasi Wali Songo Dalam Pengembangan Budaya Islam di Nusantara
Authors: Rosyadi Zainal , Wafa Khoirul , Muttaqin Asyharul , Nurngaini Imam
Published: May 2023

Wali Songo sangat terkenal sebagai dewan dakwah dan berhasil menanamkan akidah dan syariat Islam di Nusantara khususnya di Pulau Jawa.  Wali Songo merupakan  orang yang senantiasa beriman dan taqwa kepada Alloh SWT, menyampaikan kebenaran dari Alloh SWT, memiliki karomah dari Alloh SWT suatu kemampuan di luar adat kebiasaan manusia. Peran Wali Songo sangat besar diantaranya sebagai pelopor, pejuang ahli bidang agama Islam, pemimpun, guru, kyai dan tokoh masyarakat.  Masyarakat mengenal Wali Song  sebagai sembilan orang, yaitu Syeh Maulana Malik Ibrahim, Sunan Ampel, Sunan Bonang, Sunan Giri, Sunan Drajat, Sunan Kalijaga, Sunan Gresik, Sunan  Giri dan Sunan Gunung Jati.  Berbagai pendapat menyebutkan bahwa Wali Songo tidak hidup dalam satu masa namun terbagi dalam beberapa periode dan berganti apabila ada yang wafat. Berakhirnya periodesasi Wali Songo karena dibekukan oleh Kolonial Belanda dan banyak para ulama keturunan Wali Songo yang dipenjara dan dibunuh.

 

Wali Songo is very well known as a da'wah council and has succeeded in instilling Islamic faith and sharia in the archipelago, especially on the island of Java. Wali Songo is a person who always has faith and piety to Allah SWT, conveys the truth from Allah SWT, has karomah from Allah SWT, an ability beyond human habits. Wali Songo's role is very large, including as a pioneer, expert fighter in the field of Islam, leaders, teachers, kyai and community leaders. The community recognizes Wali Songo as nine people, namely Sheikh Maulana Malik Ibrahim, Sunan Ampel, Sunan Bonang, Sunan Giri, Sunan Drajat, Sunan Kalijaga, Sunan Gresik, Sunan Giri and Sunan Gunung Jati. Various opinions state that Wali Songo does not live in one period but is divided into several periods and changes when someone dies. The end of the periodization of Wali Songo because it was frozen by the Dutch Colonial and many ulama descendants of Wali Songo were imprisoned and killed.