bluuebunny/crossref_metadata_2025 huggingface dataset:
Abnormal Promoter Methylation of Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) Gene in the Pathogenesis of Crohn’s Disease
Authors: Sanati Golshid , Noruzinia Mehrdad , Jafari Davood , Ahmadvand Mohammad , Teimourian Shahram , Daryani Naser Ebrahimi , Rezaei Nima
Published: August 2023

Changes in the expression of nucleotide-binding oligomerization domain containing 2 (NOD2) play an important role in the pathogenesis of several autoimmune diseases, such as inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC). It seems that epigenetic modifications, including DNA methylation, have an important role in the suppression of gene activity. In this study, the relationship between DNA methylation patterns of the promoter region of the NOD2 gene and the pathogenesis of CD was assessed. Colonic mucosal samples were obtained from 15 Iranian patients with CD and 15 matched healthy controls with no history of autoimmune diseases. After bisulfite conversion of genomic DNA, the DNA methylation status of three CpG sites in the promoter region of the NOD2 gene was determined by the real-time quantitative multiplex methylation-specific PCR assay. Using this approach, we identified a decreased level of methylation of the NOD2 promoter in the colonic mucosa of patients with CD (0.128±0.093 vs. 0.025±0.016, unmethylated DNA in CD vs. healthy controls, respectively, P<0.000). According to our findings, promoter hypomethylation of the NOD2 gene in the colonic mucosa might contribute to the development and severity of CD.
Prognosis, Survival and Management of Pediatric Patients With Neuroblastoma: A 12-Year Experience From a Single Center Study
Authors: Mehrvar Azim , Sadeghi Yasaman , Mehrvar Narjes , Faranoush Mohammad , Alebouyeh Mardawij , Roozrokh Mohsen , Tashvighi Maryam
Published: August 2023

In this cross-sectional study, we aimed to evaluate epidemiologic data, survival, and prognosis of pediatric patients diagnosed with neuroblastoma who were referred to Mahak Pediatric Cancer Treatment and Research Center (MPCTRC). One-hundred thirty-seven children younger than 15 years with neuroblastoma from April 2008 to March 2020 were included in this study. Data were retrospectively extracted from their documents, and follow-up was done for alive individuals. Collected data were analyzed using SPSS software version 25 for parametric and non-parametric variables. Of all patients, 51.82% (n=71) were male (M/F ratio was 1.07:1) with a mean age of 2.48±0.26 years. According to the International Neuroblastoma Staging System (INSS), more than 70% of patients were diagnosed with stages 3, 4, and 4S. Primary tumors were located mostly in the adrenal glands (42.34%) and abdomen (29.20%), respectively. Additionally, 62% of children experienced metastasis, with the most common site being bone marrow. Moreover, patients' overall survival, progression-free survival, and event-free survival were 55.2%±5.6, 41.0%±7.9, and 30.0%±5.1, respectively. Early diagnosis and effective treatment of neuroblastoma can directly influence patients' survival, and those who are diagnosed with neuroblastoma within one month of its symptoms onset are more likely to have higher survival rates.
Description of a Patient Suspected of Myocardial Infarction With Normal Coronary Artery: A Case Report of Takotsubo Cardiomyopathy
Authors: Mohammadi Vahid , Zakeri Mohammad Ali , Zakeri Maryam , Ehsani Vahid
Published: August 2023

Takotsubo cardiomyopathy (TC) is characterized by transient systolic dysfunction, presenting with electrocardiographic (ECG) changes and mimicking acute coronary syndrome (ACS). Studies have shown that 95% of patients have changes in ECG. ECG changes in TC syndrome may be similar to myocardial infarction )MI(. ECG changes can be seen in the form of ST-segment elevation or deep T-wave inversion. TC can be considered a special form of ACS. TC is not a benign entity, and conduction abnormalities can occur. The acute phase can be predicted based on decreased EF and arrhythmia. Different treatments are used in the acute phase of TC, depending on the hemodynamic condition. Our case elucidates the importance of age, female gender, symptoms, such as stress and emotion, clinical manifestations, ECG characteristics, and echocardiography in TC. This paper describes a case of TC from a hospital affiliated to Rafsanjan University of Medical Sciences. The case was a 75-year-old woman with no history of cardiovascular diseases who has been admitted to the hospital with myocardial infarction.
Literature Review of Frailty and Multi-morbidity in Older Adults: Exploring the Complex Relationship
Authors:   Department of Medicine, Faculty of Medicine, Basubrain Omar Sami
Published: August 2023

In older adults, frailty and multi-morbidity are common conditions that lead to the increase vulnerability, healthcare outcomes and poor physical and mental health outcomes. This literature review contributes to the study of the complex and dynamic relationship of multi-morbidity and frailty. It also emphasizes various other factors that contribute to the frailty irrespective of presence of multi-morbidities. On dissecting existing literature, it is observed that high physical activity levels and functional independence play pivotal role on older adults in development of frailty. The presence of multiple morbidities and co-morbidity are indicators for development of risk of frailty. The targeted rehabilitation and treatment plan can help older adults to achieve good health outcomes in frail multi-morbid older adults. The frailty scoreis recognized tool for assessment of chronic stress and frailty known as Rockwood score system. The score system presents insightsinto frailty and multiple morbidity of older adults. Keywords: Frailty, older adults, multi-morbidity, functionality, Rockwood Frailty Score, comorbidity.
PROGNOSTIC VALUE OF THE ABCD AND IMS FOR EVALUATION OF TYPE 2 DIABETES MELLITUS REMISSION AFTER BARIATRIC SURGERY
Authors: Neimark A. E. , Molotkova M. A. , Makarova E. O. , Galchenko M. I.
Published: August 2023

Background. Significant proportion of patients with obesity and type 2 diabetes mellitus (DM) have significant weight loss and improved metabolic outcomes as a result of bariatric surgery. To predict the effect of surgical treatment of DM, several scales have been proposed, including ABCD and IMS.Objective. To estimate accuracy of the ABCD and IMS scales in predicting DM remission in patients undergoing bariatric surgery.Design and methods. 38 patients with type 2 diabetes were identified after bariatric surgery with a follow-up period of at least 1 year. The KNIME Analytics Platform 4.3.6 (KNIME AG, Switzerland) was used for data processing.Results. 12.8 % of patients achieved partial remission, 52.6 % complete remission, and 31.6 % did not achieve remission. According to the IMS, no significant results were detected in the remission groups. IMS scale have a low predictive value. A significant result was obtained for the ABCD after CAIM binning. For the binary classification (“Remission”/”Haven’t remission”): AUC = 0.98 and Cohen’s kappa k = 0.86 for probability treshold 0.55399, that maximized F-measure (0.96) were obtained. So, ABCD predictive value is high.Conclusion. The ABCD have a better predictive value. Ease of use, good prognostic effect allows us to recommend ABCD before bariatric treatment.
KISSPEPTIN SIGNALING IN MENSTRUAL DISORDERS IN OBESE ADOLESCENT GIRLS
Authors: Liskina A. S. , Vasilieva E. Yu. , Zazerskaya I. E. , Nikitina I. L.
Published: August 2023

Background. Menstrual cycle disorders (MCD) are common among adolescent girls.Objective. To study the level of plasma kisspeptin in adolescent girls with obesity and MCD.Design and methods. The study included 80 adolescent girls with obesity. Group 1 — with MCD, group 2 — without MCD. Inclusion in groups 1 year or more after menarche. Laboratory examination included assessment of carbohydrate and lipid metabolism, hormonal examination.Results. There were no significant differences in SDS BMI between the groups (p = 0.486 and p = 0.459). Significantly higher in group 1: impaired carbohydrate tolerance (NTU), hypertriglyceridemia (p = 0.022), levels of kisspeptin, luteinizing hormone (LH), total testosterone, anti-muller hormone (AMH), free androgen index (ISA) (p = 0.001, p = 0.008, p = 0.026, p = 0.014, p = 0.027, respectively). The estradiol level in group 2 was significantly higher than in group 1 (p = 0.012). According to the results of the ROC analysis, the optimal value of the plasma kisspeptin level was found to be 53.56 pg/ml.Conclusion. Obese and MCD patients have significantly higher levels of kisspeptin, as well as LH, AMH, and testosterone than adolescent girls with similar severity of obesity without MCD. The plasma kisspeptin level is 53.56 pg/ml. It can be used as a new diagnostic criterion for predicting the risk of MCD in obese girls. Obese and MCD patients are significantly more likely to have NTU and hypertriglyceridemia compared to obese patients without MCD.
VASOSPASTIC ANGINA DUE TO DESTRUCTIVE THYROTOXICOSIS IN A PATIENT AFTER HEART TRANSPLANTATION: CASE-REPORT
Authors: Tsiberkin A. I. , Sazonova Yu. V. , Simonenko M. A. , Fedotov P. A. , Yudina O. V.
Published: August 2023

In current study, we described the onset of a case of vasospastic angina against the background of thyrotoxicosis.In a 48-year-old patient with transplanted heart coronary artery disease and achieved revascularization after stenting, anterior ventricular failure is used and episodes of ST elevation are preserved in the nighttime indicators of Prinzmetal’s angina in leads characterizing the potentials of the anterior septal (V1–V3), complete anterior (V4–V5), lateral (V6, I), lower diaphragmatic (III, avF) tissue of the left ventricle regardless of physical activity and despite optimal drug therapy with calcium channel blockers and nitrates. The patient did not have characteristic clinical signs of thyrotoxicosis, probably due to ongoing immunosuppressive therapy, in particular, glucocorticosteroids.Destructive thyrotoxicosis was diagnosed due to high T4\T3 ratio, absence of TSH receptor antibodies, and a diffuse decrease of 99mTc-pertechnetate uptake. After increasing the dose of glucocorticosteroids and achieving euthyroid state, the episodes of ST elevation resolved.This case emphasizes the importance of timely detection and proper differential diagnosis of thyrotoxicosis. The clinical course of thyrotoxicosis in patients with severe cardiovascular pathology is often atypical and complicated. Restoration of normal thyroid function may lead to the regression of associated cardiac arrhythmias.
CASE OF GALVANIC SYNDROME AFTER CRANIOPLASTY BY A TITANIUM IMPLANT WITH DEVELOPMENT OF NEOOSTEOGENESIS CELLS OF THE SKULL BONES
Authors: Trofimov V. E. , Voinov N. E. , Rybakov G. Yu. , Kalmens V. Ya. , Samochernykh K. A.
Published: August 2023

There was a constant searing pain in the right side of the head and a face that was not buying analgesics in a 61-year-old woman, after surgery in 2018 to remove a meningioma in the right frontal lobe followed by a cranioplasty titanium implant. Evaluation of immune status revealed that the allergological test for titanium was positive. According to the results of the MR-study of data for continued growth of the tumor, as well as signs of vasonary conflict of the trigeminal nerve.The possible development of the galvanic syndrome in patient has been suggested. Thus, the decision to remove the titanium implant has been made. During the operation, the presence of galvanic current (from 3–46 μA) on the titanium plate surface was documented and instrumentally confirmed.Under the titanium implant during the operation, ectopic foci of neoosteogenesis were visualized. The condition improved in the form of a complete regression of pain syndrome after removing the titanium implant.The present clinical case is the world’s first description of the development of galvanic syndrome on the surface of titanium cranioplastic mesh. The presence of electroplating repair of bone tissue can be a new step in solving the problem of closing skull defects in neurosurgical patients.
MRI OF THE CHEST IN ASSESSING THE SEVERITY OF PULMONARY ARTERIAL HYPERTENSION IN PATIENTS UNDERWENT COVID-19
Authors: Vasiltseva O. Ya. , Ignatenko G. A. , Bergen T. A. , Tarkova A. R. , Nudnov N. V. , Pervak M. B. , Vorobeva V. O. , Lishmanov Yu. B. , Ussov W. Yu. , Cherniavsky A. M.
Published: August 2023

Background. Chest MRI allows diagnosing in the acute period of covid-associated pneumonia (CAP) and assessing the dynamics of treatment. The potential of MRI in postcovid pulmonary arterial hypertension (PAH) study remains unclear. Objective. To examine the chest MRI picture in CAP patients and to quantify the signs of post-COVID PAH. Design and methods. The study included 34 patients who underwent COVID-19 within 3.5–7 months with involvement of the parenchyma of mild severity upon admission of CT1–CT3 according to spiral X-ray CT. All patients underwent chest MRI in ECG- and respiratory-synchronized T1- (T1-WI), T2 (T2-WI) and diffusion-weighted MRI protocols and ultrasound of the heart and large vessels of the chest cavity, with the calculation of systolic pressure in the right ventricle (SPRV). Results. Three groups were distinguished: CT1 (group 1), CT2 (group 2) and CT3 (group 3). The frequency of subsegmental/segmental signs of LA branches thromboembolism was significantly higher in groups CT2 and CT3. LA diameter, SPRV and T1-WI intensity ratio index {Lung/LA} progressively increased from group 1 to group 3. The dependence of SPRV on the {Lung/LA} was fitted using Boltzmann curve (r = 0.92, p < 0.01). Conclusion. Chest MRI in T1- WI allows assessing the degree of post-covid changes in the lung parenchyma thickness and predicting early forms of increased pulmonary arterial pressure and the formation of PAH.
Współczesne miasta. Aktualne możliwości rozwoju
Authors: Stawasz Danuta
Published: August 2023

Tematem przewodnim monografii jest miasto w relacji współczesny świat – gospodarka – społeczeństwo – system władzy i zarządzania. Rozważania koncentrują się wokół pytania, jakie czynniki decydują o możliwościach rozwoju współczesnego miasta co sprawia, że jedne odnoszą sukcesy, inne zaś mimo wydawałoby się sprzyjających okoliczności nie nadążają za dynamiką zmian obserwowaną w różnych miejscach i obszarach ludzkiej aktywności. W publikacji została podjęta próba całościowego spojrzenia na niezwykle istotne dla współczesnych miast zagadnienie ich rozwoju, rozpatrywane w kontekście sprawności zarządzania warunkującego zapewnienie w długim okresie równowagi między możliwościami i oczekiwaniami budowania miasta zaspokajającego potrzeby i aspiracje miejskiej społeczności. Inaczej budowania miasta przez ludzi i dla ludzi, zgodnie z wymogiem zagwarantowaniem interesu publicznego. Punktem wyjścia podjętych rozważań jest przyjęcie założenia, że prawa ekonomiki miasta nie straciły na swojej aktualności i powinny być uwzględniane przez decydentów przy podejmowaniu decyzji co do kształtowania procesów rozwojowych miasta.
Standing finansowy a zrównoważony rozwój przedsiębiorstw w Polsce. Badania sektorowe
Authors: Kowalska Magdalena
Published: August 2023

Zrównoważony rozwój przedsiębiorstw to proces zmian ilościowych i jakościowych ukierunkowany na osiąganie korzystnych wyników w wymiarze ekonomicznym, społecznym oraz środowiskowym. Jednym z kluczowych czynników wpływających na zrównoważony rozwój przedsiębiorstw jest standing finansowy, utożsamiany z ogólną sytuacją finansowo-majątkową przedsiębiorstwa, jego wiarygodnością i zdolnością do regulowania zobowiązań. Podstawowym celem monografii jest ocena wpływu standingu finansowego na zrównoważony rozwój przedsiębiorstw wg sekcji PKD2007 w latach 2008-2019. Realizacja celu badawczego wymagała zastosowania metody krytycznego i retrospektywnego przeglądu wyselekcjonowanej literatury przedmiotu, polskiej i zagranicznej, analizy przyczynowo-skutkowej, opracowania modeli ekonometrycznych. Układ pracy podporządkowany został weryfikacji przyjętej hipotezy głównej – „Standing finansowy ma istotny statystycznie wpływ na zrównoważony rozwój przedsiębiorstw wg sekcji PKD2007 w latach 2008-2019”. Sustainable development of enterprises is a process of quantitative and qualitative changes aimed at achieving favorable results in economic, social and environmental dimensions. One of the key factors affecting the sustainable development of enterprises is the financial standing, identified with the general financial and property situation of the enterprise, its credibility and ability to settle liabilities. The main objective of the monograph is to assess the impact of the financial standing on the sustainable development of enterprises according to the section of Polish Classification of Economic Activities in 2008-2019. The implementation of the research objective required the use of the method of critical and retrospective review of selected literature on the subject (Polish and foreign), cause-and-effect analysis, creation of econometric models. The layout of the work was subordinated to the verification of the adopted main hypothesis - "Financial standing has a statistically significant impact on the sustainable development of enterprises according to the section of Polish Classification of Economic Activities in 2008-2019". The monograph consists of an introduction, six chapters, conclusion, bibliography, list of figures, tables and charts. The introduction contains a synthetic approach to the issues, the main hypothesis and sub-hypotheses. The first two chapters are theoretical and related to the sustainable development of enterprises and the financial standing as its determinant. The third chapter presents the research methodology. The next three chapters present the empirical analysis. At the end, a summary and conclusions resulting from the research are presented.
Self-assessed health of adult Australian sport club participants during and after COVID- 19 restrictions: a longitudinal study
Authors: Eime Rochelle , Harvey Jack , Charity Melanie
Published: August 2023

Background: Internationally, COVID-19 restrictions impacted negatively on participation in sport and physical activity. Participation in community club sport was particularly disrupted with cancelled training and competitions, and this has been shown to impact the health of individuals. We now need to investigate the effects of the lifting of COVID-19 restrictions.
Aim: The aim of this study was to longitudinally investigate the health of Australian adult sports club participants, during and post-COVID-19 restrictions.
Methods: Two waves of an online survey were conducted in mid-2020 and mid-2021. The first wave also captured retrospective pre-COVID19 (2019) data. For each year 2019-2021 each survey respondent was categorized as participating (Yes/No) in club sport. Respondents also assessed their current health (overall, physical and mental) in both 2020 and 2021. The six health assessments were cross-tabulated against three patterns of participation (dropout, dropout and return, continuation), for the survey sample overall and for six demographic subsamples: 42 crosstabulations in all.
Results: A total of 1,037 Australians aged 18 years and above completed both survey waves. Those who continued playing club sport throughout, and to a lesser degree those who returned to club sport in 2021, reported better physical and general health than those who dropped out. This pattern was consistent, for the overall survey sample and for the sub-samples based on gender, age and region of residence, with statistically significantly associations (p<0.05) in 24 of 28 analyses. The pattern of club sport participation was only weakly associated with reported mental health, with only one of 14 associations being statistically significant.
Conclusion: Changes in club sport participation impact general and physical health of adults; continuation or return were associated with better physical and general health than drop-out. There was little evidence of an association between participation in sport and mental health, which is inconsistent with previously reported cross-sectional results; this may be due to a combination of factors, including confounding with the broader effects of the pandemic. In conclusion, it is clear that retention in participation in sport is not just important for sports management policy and strategies; it is also important for the health of individuals.
Phenotypic plasticity, spatial niches and cancer-associated fibroblast/mural cell interactions define the human prostate cancer microenvironment
Authors: Sampson Natalie , Brunner Elena , Damisch Elisabeth , Fotakis Georgios , Trajanoski Zlatko , Schäfer Georg , Nommensen Lukas , Neumann Lucy , Puhr Martin , Culig Zoran , Karkampouna Sofia , Bonollo Francesco , de Julio Marianna Kruithof
Published: August 2023

Due to their established roles in tumor progression and therapy resistance, cancer-associated fibroblasts (CAFs) are considered key therapeutic targets. However, a lack of pre-clinical models has hampered the functional characterization of tumor-promoting versus tumor-suppressive CAF substates, a priori for the development of CAF-targeted therapeutics. We describe and cross-validate a biobank of primary human prostate inflammatory (iCAFs) and myofibroblastic (myCAFs) CAFs that closely recapitulate fibroblast heterogeneity in clinical prostate cancer (PCa) and retain key functional hallmarks pertinent to their CAF substate. iCAFs and myCAFs coexisted in clinical specimens but localized to distinct spatial niches and differentially expressed androgen receptor (AR). Pro-migratory AR-negative myCAFs retained high plasticity in a biomechanical-sensitive manner and were associated with hallmarks of poor outcome. Consistently, myCAFs represented the dominant CAF subpopulation in fibroblast-rich high-grade PCa and castration-resistant patient-derived xenografts. Conversely, AR-positive iCAFs were associated with a favorable prognosis. In view of the androgen-dependent but tumor-suppressive nature of parenchymal smooth muscle cells, these findings imply the potential inadvertent ablation of protective AR+ stromal cell types during androgen deprivation therapy may favor accumulation of aggressive AR-negative/castration-resistant myCAFs. The CAF biobank generated herein thus represents a valuable experimentally-tractable tool for the future design of CAF-targeted therapeutics to overcome therapy resistance.
STUDY OF WEAK FORM OF MARKET EFFICIENCY IN INDIA
Authors:   Institute of Management and Research, MGM University Aurangabad., Dubey Tanuja
Published: August 2023

A securitys current market price already accounts for all of its prior trading volumes and prices, according to Indias lax form of market efficiency. An investor cannot generate spectacular returns by only relying on the analysis of previous price movements because any relevant information about the security would already be reflected into its present price. The accuracy and promptness with which prices reflect information about the market is known as market efficiency. All the information from prior prices and traded volume is included in the weak version of the markets current prices. Furthermore, future prices cannot be predicted by looking at past prices. Everyone has access to past prices, even though some people can obtain them more easily than others. Liquidity traders may sell their stocks, generating price volatility, without considering the shares fundamental value. The market price reflects the intrinsic value as a result of the buying and selling of information traders. The filter rule, runs test, and serial correlation are used to assess market efficiency. Run tests have been used in this research to identify market efficiency. Information on stock prices for the selected companies was gathered from the National Stock Exchange (NSE).
ADVERSE DRUG REACTIONS (ADRS) OF CISPLATIN IN PULMONARY CANCER PATIENTS- ONE YEAR PROSPECTIVE STUDY
Authors:   Lecturer Department of Medicine, GMC Jammu., Singh Joginder , Kumar Vinod ,   Lecturer Department of Medicine, GMC Jammu., Jandyal Sunny ,   Lecturer Department of Oncology, GMC Jammu., Rani Rekha ,   Lecturer, Department of Pharmacology GMC, Jammu.
Published: August 2023

Background: A cross sectional prospective observational study evaluated the trends and patterns of Adverse drug reactions of cisplatin in pulmonary cancer patients . Methods:Pulmonary cancer patients, who received cisplatin as chemotherapy regimen, were monitored for adverse reactions. New and old diagnosed cases of pulmonary cancer patients belonging to either gender and of all ages, who were receiving cisplatin under any standard regimen, were included for the study. Any ADR due to poisoning, over dosage were excluded from the study. The ADRs were recorded in Central Drugs Standard Control Organization forms. Casuality was assessed by the WHO Casuality Assessment Scale and Naranjos Alograthim. Results:A total number of 98 patients were reported during the study period, wherein a total number of 114 ADR cases were observed.The majority of patients were in the age group of 61-80 (n=45), followed by 41 -60 years (n=41, 41.83%) .Out of the total ADRs, most frequently reported one was vomiting 18 (15.78%) followed by anemia 16 (14.03%), nausea 13(11.40%) and hair loss 12 (10.52 %) which together constituted 51.73 % of the total ADRs. The other commonly encountered ADRs were diarrhea 8 (7.01%), thrombocytopenia 6 (5.26%), constipation 6 (5.26%) neutropenia 5(4.38) and neuropathy 5(4.38%).According to WHO-UMC scale, 37(37.75%) of reports to be certain,33(33.67%) of reports to be possible and 28(28.57%) of reports to be probable where there was no case recorded as unclassified or inaccessible.Naranjos scale which classified 65 (66.32%) to be probable and remaining 33 (33.67%) to be possible. Conclusion:Cisplatin has high potential for adverse effects. There is a need to improve the management of adverse effects. This study also emphasizes the need to improve pharmacovigilance awareness among physicians in order to improve the pharmacovigilance in India.
ALOE VERA - A REJUVENATINGNATURAL REMEDY REVIEW
Authors:   Asso Professor Acsdr Kerala India., B. Joseph Biju
Published: August 2023

The Aloe Vera plant has been known and used for centuries. It is a true gift from nature. Ancient records show that the benefits of Aloe Vera have been known for centuries with its therapeutic advantages and healing properties. It is considered under any names depending upon the world community . the medicinal uses of this tropical plant is verry well found in many literures dated back . The nutrients make up of Aloe Vera is one of a kind and has amazing natural healing properties. Its uses are multiple and undoubtedly the natures gift to humanity and it remains for us to introduce it to ourselves and thank the nature for its never-ending gift.
COMBINATION OF CARBON DIOXIDE LASER AND TOPICAL 5-FLOUROURACIL FOR PREVENTION OF RECURRENCE OF KELOID
Authors: Ittigi Vivekananda
Published: August 2023

Background: The treatment of keloid has been a challenge, and at times, frustrating because of the recurrence. Hence, it is essential to find treatment modality with least recurrence and good cosmetic results. This study showed the effect of topical 5-fluorouracil following carbon dioxide laser excision on recurrence of keloid. Aim: To evaluate the efficacy of combination of carbon dioxide laser and topical 5-flourouracil(5%) in prevention of recurrence of keloid. Material and methods: Total 24 patients (20 females and 4 males) of age group 12-56 years having keloid of duration 1-8 years were included in this study. Lesions were present on ear lobes, shoulder, chest, leg. CO2 laser was used in continuous mode to excise the lesions and all patients advised topical 5-FU(5%) once daily application over the lesion in the night, once re-epithelization started, for 4 weeks. The patients were followed up initially at every week for 4 weeks then every 4 weeks for 24 weeks to evaluate the response of treatment. Result: Of the 24 patients evaluated at 24 weeks, none (0%) showed any sign of recurrence. Out of 22 patients four(18.2%) patients complained of burning sensation/irritation. Three (13.6%) patients of erythema and erosion which cleared with temporary discontinuation of topical 5-FU and completed the 4 weeks of topical therapy. Three (13.6%) patients developed hypopigmentation. Conclusion: Though response of this combination is encouraging in prevention of recurrence of keloid, recurrence on long term follow up need to be observed.
ULIPRISTAL ACETATE VERSUS PLACEBO FOR FIBROID TREATMENT
Authors:   Mbbs, Dgo,Dnb, Jnmch, Amu, Aligarh Assistant Professor Lbkmch (Saharsa)., a Shipika
Published: August 2023

Background: The efficacy and safety of oral ulipristal acetate for the treatment of symptomatic uterine fibroids before surgery are uncertain. Methods: We randomly assigned women with symptomatic fibroids, excessive uterine bleeding (a score of >100 on the pictorial blood-loss assessment chart [PBAC, an objective assessment of blood loss, in which monthly scores range from 0 to >500, with higher numbers indicating more bleeding]) and anemia (hemoglobin level of â‰¤10.2 g per deciliter) to receive treatment for up to 13 weeks with oral ulipristal acetate at a dose of 5 mg per day (96 women) or 10 mg per day (98 women) or to receive placebo (48 women). All patients received iron supplementation. The coprimary efficacy end points were control of uterine bleeding (PBAC score of <75) and reduction of fibroid volume at week 13, after which patients could undergo surgery. Results: At 13 weeks, uterine bleeding was controlled in 91% of the women receiving 5 mg of ulipristal acetate, and 19% of those receiving placebo (P<0.001 for the comparison of each dose of ulipristal acetate with placebo). The rates of amenorrhea were 73%, and 6%, respectively, with amenorrhea occurring within 10 days in the majority of patients receiving ulipristal acetate. The median changes in total fibroid volume were âˆ’21%,, and +3% (P = 0.002 for the comparison of 5 mg of ulipristal acetate with placebo. Serious adverse events occurred in one patient during treatment with 5 mg of ulipristal acetate (uterine hemorrhage) and in one patient during receipt of placebo (fibroid protruding through the cervix). Headache and breast tenderness were the most common adverse events associated with ulipristal acetate but did not occur significantly more frequently than with placebo. Conclusions: Treatment with ulipristal acetate for 13 weeks effectively controlled excessive bleeding due to uterine fibroids and reduced the size of the fibroids.
THORAX AND IDIOPATHIC SCOLIOSIS
Authors:   Orthopaedic Surgeon, Former Head for the Orthopaedic and Traumatology Department of Tzaneio General Hospital of Piraeus, Piraeus, Greece., B. Grivas MD PhD Theodoros
Published: August 2023

This review is related to the role of thorax in scoliogenesis. The embryology, the prenatal and the postnatal growth of the rib cage of (RC) and the lungs are briefly described. The development of normal RC, the frontal and sagittal diameters of it, the values of mid-thoracic diameters, the thoracic index, the biomechanical contribution of the RC to thoracic stability, the increase in frontal and sagittal thoracic diameter during breathing are defined. The infancy, childhood, puberty (ICP) model of growth is used in both the segmental thoracic ratios (TR) and the Segmental Rib-vertebra angles (RVA) in order to assess the normal and deformed RC in Early Onset (EOS) and Late Onset Scoliosis (LOS). The neuromuscular mechanisms as possible factors causing age-related RVAs changes are discussed. Then the posterior truncal/thoracic asymmetries are reviewed related to school scoliosis screening (SSS) referrals. Next, the development of RC is analyzed in resolving and progressive infantile idiopathic scoliosis (IIS), and in adolescent idiopathic scoliosis (AIS). The menarche and laterality of thoracic scoliotic curves, congenitally fused ribs and pulmonary function in children with idiopathic scoliosis (IS) is also discussed. The pathogenesis of IS according to the Nottingham concept and RC, the thorax and pelvis complex during gait and rotational inertia, the Double Rib Contour Sign (DRCS) and Rib Index (RI), the effect of growth on the relationship of spinal and thoracic deformity are explained. The postoperative fate of IS hump deformity in relation to the RI and the aetiological implications for IS are then stated. The role of the rib-sternum complex is mentioned. John Sevastiks thoracospinal concept of aetiopathogenesis of AIS and his research about IS are described, namely experiments on ribs, correction of experimentally produced scoliosis, suggested surgical intervention on the ribs, experiments on nerves, vascular changes in the chest wall after unilateral resection of the intercostal nerves, and breast asymmetries in female suffering AIS. A biomechanical model using different Cobb angle and rib hump (RH) correction is mentioned. The issue of thoracic kyphosis and hypokyphosis and the impact of the lateral spinal profile (LSP), that is the sagittal plane, is discussed. Finally, IS and evolution of thoracic shape as a scar of evolution are pointed out.
SYNTHESIS, CHARACTERIZATION, ANTIBACTERIAL TEST AND MOLECULAR DOCKING OF SOME AMIDE DERIVATIVES
Authors:   Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq., Ali Karim Hussien , Amer Musa Luma ,   Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.
Published: August 2023

The amide group is an organic group synthesized by reaction between an amine and carboxylic acid and is known to have many biological activities like antibacterial, antifungal, anti-inflammatory, antitumor and many other activities.the traditional and easy method to synthesize amides by first convert carboxylic acid to acyl chloride and then the acyl chloride react with amine to give the amide .the goal is to synthesize new amide derivatives by one pot reaction between two drugs one is amine ( bromohexine which act as mucolytic) And the other drug is carboxylic acid like NSAIDs ( diclofenac, naproxen, indomethacin and mefenamic acid) using thionyl chloride and triethylamine as catalytic agents and stirring for 1 hr. The result products will be characterized by physical examination, melting point and IR spectroscopy. As mentioned the amide derivatives have many biological activities so the antibacterial activity will be tested on some bacterial species 2 g+ve( staph.aureus and streptococcus) and 2 g-ve ( E.coli and Klebsiella). Finally the docking study will be done on the synthesized derivatives on the proposed targets to see the inhibition score for each derivatives and compare it with the reference inhibitor and with antibacterial test.
DUCTAL CARCINOMA IN SITU ARISING WITHIN BREAST FIBROADENOMA: A CASE REPORT AND REVIEW OF THE LITERATURE
Authors:   Anatomy Pathology and Cytology Laboratory, National Institute of Oncology, 10000, Rabat, Morocco., Mouhoubo I. , Chadi F. ,   Anatomy Pathology and Cytology Laboratory, National Institute of Oncology, 10000, Rabat, Morocco., Kmou M. ,   Anatomy Pathology and Cytology Laboratory, National Institute of Oncology, 10000, Rabat, Morocco., Khanoussi B. ,   Anatomy Pathology and Cytology Laboratory, National Institute of Oncology, 10000, Rabat, Morocco.
Published: August 2023

Fibroadenoma is the most common benign breast tumor in women under 30. However, carcinoma arising in a fibroadenoma is unusual and very rare, with over 100 cases reported in the literature. Histological diagnosis is usually incidental. We report the case of a 51-year-old perimenopausal patient with a family history of a mother who died of breast cancer. She was admitted with a hard elastic mass in the upper outer quadrant of her left breast. Imaging revealed a heterogeneous nodule with ductal dilatation. A core needle biopsy with four specimens showed a fibroepithelial tumor with atypical ductal hyperplasia. Left breast-conserving surgery was performed for radical treatment. The diagnosis on the specimen was carcinoma in situ of intermediate nuclear grade and massive compact and cribriform type developed on a fibroadenoma. We present this case to raise awareness of this entity and highlight the need for histological evaluation of specific breast masses.
The representation of EFL context-based cultures in an international EYL textbook
Authors: Nurhayati Lusi , Triastuti Anita , Widodo Pratomo
Published: August 2023

The present content analysis study intended to investigate the cultural contents of an international EYL textbook used in Indonesian private elementary schools. It examined the representation of cultural themes categorized under the big "C" and small "c" cultures and the representation of EFL context-based/Indonesian cultures in each theme. The findings of the study revealed that (1) the book covered all themes, but their representation is not balanced; (2) some aspects of local cultures were represented in the books, but the number was very limited and less varied. The implication of this study suggests that the international EYL textbook should allocate adequate space for local culture. Hence, this could be seen as an opportunity for EYL teachers and practitioners to use their authority and to empower themselves by providing supplementary materials that best suit their local needs. Keywords: culture, themes, local, representation, international, EYL textbook
Personal Health Tracking: A Paradigm Shift in the Self-Care Models in Nursing
Authors: Choi Soyoung
Published: August 2023

The rapidly evolving digital health landscape necessitates updates to existing self-care models in nursing. This viewpoint paper revisits and evaluates prevalent models, recognizing their comprehensive exploration of self-care concepts while also identifying a gap in the incorporation of personal informatics. It underscores the missing link of human-technology interplay, an essential aspect in understanding self-care practices within digital generations. The author delineates the role of personal health tracking in self-care and the achievement of desired health outcomes. Based on these insights, the author proposes a refined, digitized self-care model that incorporates mobile health (mHealth) technologies and self-tracking behaviors. The paper concludes by advocating the application of this model for future mHealth nursing interventions, providing a framework for facilitating patient self-care and improving health and well-being in the era of digital health.
Malware Detection and Classification Using Machine Learning Algorithms
Authors: Chiwariro Ronald , Pullagura Lokaiah
Published: August 2023

Abstract: Malicious software, or malware, can take the form of executable code or system library files in the form of viruses, worms, or Trojan horses, all of which aim to compromise system security and user privacy. Detecting malware is done by analysing malware signatures and behaviour patterns statically and dynamically. It has been proven that these methods are ineffective and time-consuming when it comes to detecting unknown malware. The latest malware can be identified using machine-learning algorithms. Hence, this study aims to determine the most effective machine-learning algorithm for malware detection and classification. XGBoost, LightGBM, and Logistic Regression were used as algorithms for developing machine learning models. Pre-processing of the data is followed by training and testing of the models. The dataset containing information about various malware and their characteristics was obtained from Kaggle. A variety of metrics are used to evaluate the performance of the three models, including accuracy, precision, true negative rate, and false negative rate. Based on the analysis, it has been found that the LightGBM algorithm has the highest accuracy and precision. As a result, it follows that the LightGBM algorithm is the most effective algorithm for detecting and classifying malware.
Building an Optimal Portfolio: Exploring Risk and Return in Five Distinct Sectors
Authors: Kumar S Mohan , M Sunil , Chinnasamy Dr. Gopalakrishnan , S Dr. Vinoth.
Published: August 2023

Abstract: This study uses a quantitative research design to examine the risk and return characteristics of assets in five diverse sectors and build an optimal investment portfolio. To fulfil the research objectives, historical data and financial measurements were used. Standard financial performance indicators have been created to analyse the risk and return characteristics of assets within each sector. The metrics were utilized to analyse the data in this study are expected return, standard deviation, beta and Treynor ratio. Comparative evaluations have been performed to compare each sector's risk and return profiles. Statistical tests, such as Covariance, used to find significant differences in returns and risk measures between sectors. To create optimal investment portfolios, efficient portfolio creation approaches such as mean-variance optimization have been used. The goal is to find asset allocations that maximize returns for different levels of risk tolerance. Portfolios were built using various asset pairings from the five sectors.
Advancing Autonomous Navigation: Deep Learning Techniques for Self-Driving Cars
Authors: Kapadia Riya , Mehta Kush
Published: August 2023

Abstract: The fast development of self-driving car technology has brought forth radical breakthroughs in the world of transportation and movement. This study paper looks into the paradigm shift allowed by deep learning methods in getting stable and reliable autonomous steering for self-driving cars. Leveraging the power of artificial intelligence, particularly deep learning models, this study presents a comprehensive exploration of the multifaceted aspects involved in developing a self-driving car system that can adeptly perceive its environment, make intelligent decisions, and ensure passenger and pedestrian safety. The paper first reviews the basic concepts of self-driving cars, getting into the challenges associated with real-time awareness, scene understanding, and decision-making in complex and dynamic settings. It then shows the important role that deep learning plays in handling these challenges by studying various neural network designs designed for different tasks, including picture recognition, object detection, semantic segmentation, and path planning. The study encompasses convolutional neural networks (CNNs) for picture analysis.
Analysis of Needs for the Development of Electronic Teaching Materials Based on Problem-Based Learning (PBL)
Authors: Reno Esa Mahendra  , Astrid Sri Wahyuni Sumah
Published: August 2023

Background: The learning process emphasizes students' active involvement and is oriented towards applying the concept of learning by doing and prioritizing personal experiences through observing, asking, and communicating to increase student creativity. However, reality proves that the application and implementation of learning in schools are not as expected. Some problems include the learning process only focusing on completing the subject matter, not on forming an understanding of the subject matter for students. This study aimed to analyze the need to develop electronic teaching materials according to the needs of students based on problem-based learning (PBL) learning models in biology subjects at MAN 1 Palembang school. Methods: The research used a qualitative descriptive method with a survey method by conducting interviews and questionnaires with biology teachers and students. Questionnaires, observations, and interviews provided data collection techniques. Results: The results obtained are textbooks and learning videos are the teaching materials most often used by teachers using discovery learning and project-based learning (PjBL) models. Students' activeness can be seen when the discussion activities and presentations of assignments take place, but it does not make students think critically. Conclusion: Teachers want problem-based learning (PBL) electronic teaching materials so that students can learn the material earlier and improve learning outcomes in material that is difficult for students to understand.
Growth of Red Spinach (Amaranthus tricolor L.) Hydroponically Using POC Tomatoes and Moringa Leaves
Authors: Sepbrie Mulia Bingah Pranata  , Suparti Suparti
Published: August 2023

Background: Red spinach (Amaranthus tricolor L), one of the plants contains several important elements with high nutritional value, is liked by the community, easy to cultivate with hydroponics. Efforts to determine the growth of red spinach by administering POC as a nutrient needed by plants. The purpose of this study was to find out how red spinach plants grow in POC of a mixture of tomato extract and moringa leaf extract with the addition of coconut water hydroponically and at what concentration the most effective POC. This research was conducted at the Biology Green House FKIP UMS. Methods: this study used an experimental method with a completely randomized design (CRD) with 2 factors, namely factor 1 type of POC extract mixture and factor 2 the difference in the volume of POC so that from both factors 6 treatments were obtained with three replications for each treatment. Results: Data analysis using Two Way Anova showed that the results of the C2V2 treatment had a plant height of 2.13 cm, root length of 1.96 cm, and the highest number of leaves with 4 strands. The C1V3 treatment produced the lowest plant height, namely 1.07 cm and the C2V3 treatment produced the lowest root length, namely 0.73 cm and the C1V1, C1V3, C2V1, C2V3 treatments showed the lowest number of leaves, only 2 leaves. Conclusion: The POC of tomatoes and Moringa leaves which were given the same treatment showed that the POC of Moringa leaves were effectively used as red spinach growth nutrients.
Bacteria Isolation from Public Cemeteries Soil and Test for Resistance to Antibiotics
Authors: Laspartriana Anggita Juniar , Rahayu Triastuti , Tyastuti Erma Musbita , Sidiq Yasir
Published: August 2023

Latar Belakang: Tempat pemakaman umum (TPU) adalah tempat yang digunakan untuk penguburan jenazah dan terjadi penguraian jenazah secara aktif di dalamnya. Proses penguraian ini menghasilkan nutrisi dan mineral tanah yang dapat mendukung pertumbuhan mikroorganisme di dalam tanah termasuk bakteri yang bersifat patogen. Bakteri patogen memiliki dampak yang lebih parah apabila bakteri tersebut resisten terhadap antibiotik. Di Indonesia belum terdapat data mengenai penelitian ini sehingga penelitian ini bertujuan untuk mengetahui populasi bakteri tanah di area TPU dan resistensinya terhadap antibiotik.. Metode: Sampel tanah diambil di area TPU Bonoloyo, Surakarta, Jawa Tengah pada 3 titik masing-masing dari 2 kedalaman 20 dan 50 cm. Sampel tanah diinokulasikan pada media NA (Nutrient agar) menggunakan metode spread plate. Setelah 48 jam, dilakukan penghitungan koloni dan pengamatan morfologi koloni yang dilanjutkan dengan pewarnaan gram. Isolat bakteri yang berhasil diisolasi diuji resistensinya terhadap 3 jenis antibiotik. Hasil: Rerata populasi bakteri tanah pada blok 12, 17, dan 21 pada kedalaman 20 cm adalah 4 x x 10⁶; 8 x 10⁶; dan 1 x 10⁶ CFU/g, sedangkan pada kedalaman 50 cm adalah 2,3 x 10⁶; 6 x 10⁶; dan 4 x 10⁶ CFU/g. Morfologi koloni bakteri berbentuk irregular (26 isolat), elevasi flat (19 isolat), dan warna isolat didominasi warna putih. Hasil pewarnaan Gram diperoleh 23 isolat merupakan Gram negatif dan 22 isolat merupakan Gram positif dengan bentuk sel dominan berbentuk kokus. Uji resistensi terhadap antibiotik menunjukkan bahwa isolat-isolat bakteri tersebut sudah resisten terhadap ampisillin (28,9%), Bacitracin (64,4%), dan Cefepime (57,8%). Kesimpulan: Populasi bakteri tanah pemakaman di TPU Bonoloyo pada kedalaman berbeda tidak berbeda nyata dengan jumlah berkisar antara 1 – 8 x 10⁶ CFU/g.