bluuebunny/crossref_metadata_2025 huggingface dataset:
Abai and Russian Philosophy: Man and His Values
Authors:   Institute of Philosophy, Political Science and Religious Studies, Science Committee of the Ministry of Education and Science of the Republic of Kazakhstan, Nysanbaev Abdumalik N. , Barlybaeva Gaukhar G. ,   Institute of Philosophy, Political Science and Religious Studies, Science Committee of the Ministry of Education and Science of the Republic of Kazakhstan, Solovieva Greta G. ,   Institute of Philosophy, Political Science and Religious Studies, Science Committee of the Ministry of Education and Science of the Republic of Kazakhstan
Published: January 2023

The article attempts a comparative analysis of the concepts of two national philosophies – Kazakh and Russian. The authors turn to the problem of man, try­ing to understand how Kazakh and Russian thinkers conceive human nature, what concepts, in their opinion, are defining for a human being, what place in the characterization of human nature is occupied by universal, values: life and death, good and evil, love and hatred, mercy and compassion, God and man. In this regard, the authors analyze the legacy of the outstanding Kazakh poet, thinker, public educator and public figure Abai Kunanbaev, his philosophical concept of a universal, integral person (“tolyk adam”). The аrticle reveals the worldview of Abai, whose roots go back to the Muslim humanistic tradition, the motive of his search for moral self-determination of a person. Comparing Abai’s worldview with the views of representatives of Russian religious philosophy (Vladimir Solovyov, Ivan Ilyin, Pavel Florensky), the authors come to the con­clusion that with all the differences between these two philosophies, primarily national ones, human nature is treated in a similar way in them. This primarily concerns the understanding of religious faith as a unifying, forming principle for the inner world of a person, the unifying principle around which such universal human values as mercy, compassion, honor, conscience, national dignity, mutual understanding, peace and harmony are gathered. The authors emphasize that these values, like never before, are in demand by the modern world, torn by con­flicts, contradictions, local wars, a world that has forgotten what love is and what is the genuine truth of life.
Methodological Reductionism and the Idea of Progress in the Social Sciences and Humanities: An Internalist Perspective
Authors:   Institute of Philosophy, Russian Academy of Sciences, Sokolova Tatiana D. , Tukhvatulina Liana A. ,   Institute of Philosophy, Russian Academy of Sciences
Published: January 2023

In this paper, we consider the internalistic foundations of progress in the social sciences and humanities. Our working hypothesis is that a linear (cumulative) understanding of progress in the humanities and social sciences expresses itself in a tendency towards methodological reductionism (naturalization within episte­mology of social sciences and humanities), which, in turn, is opposed to a non­linear (pluralistic) approach that proclaims a theoretical variety and pluralism of methodological attitudes. This trend is determined by the desire to strengthen the epistemic foundations of social sciences and humanities through the recep­tion of concepts and approaches of other, “more successful” natural sciences or mathematical approaches from related fields in social sciences. Depending on how exactly the reception takes place and with which disciplines ties are built up, we distinguish three strategies for the development of naturalization. The first is a substitution strategy in which the social sciences and humanities not only borrow directly from natural sciences approaches, but also abandon their own specific research subject. The second strategy is an adaptation strategy. In this case, we are not talking about methodological substitution in its pure form, but about the possibility of partial reception of certain natural science theories and methods (or the reception of mathematical methods from related areas of social knowledge – for example, from the area of economic analysis) in accordance with the goals and objectives of social and humanitarian research (that is, the so­cial sciences and humanities retain their specific subject of research, and the me­thodological base expands through the use of scientific and mathematical meth­ods and data). And finally, the third is the validation strategy, in which the specific subject of social and humanitarian research is preserved. However, the borrow­ing of scientific methods occurs not at the stage of the research, but at the stage of assessing its results. In the paper we use specific examples from the social sci­ences and humanities to consider three strategies of reductionism (as naturaliza­tion) from the point of view of their consequences for the development of social sciences and humanities in an internalist perspective.
Integrating the global health perspective in schools of public health: lessons learned from the Covid-19 pandemic
Authors: Arroyo Hiram V
Published: January 2023

This essay discusses the need for schools of public health to convene to implement the practice of public health teaching and research by training health leaders, generating knowledge, and providing health and social services that contribute to the well-being of the community. Since their inception, the academic, research and service programs of some schools have been designed to serve as partners and allies of governments and the health sector in general. Part of their role has been to identify health risks to communities, design strategies to address major problems affecting health, create databases for assessment and intervention in conditions affecting the health of communities, as well as advise government authorities and other social sectors in health education efforts and preventive approaches. These programs have also been an essential part of the design, evaluation and implementation of organizational models of health services and institutional and community clinical care, in addition to integrate public health and health services in the development of unique models at the national level. Likewise, these have extended the scope of actions and services to other state agencies, companies and private healthsector organizations, which benefit directly from the experience of the schools of public health. The academic, research and service programs have also strengthened the professional competencies of graduates of the academic programs, who occupy essential decision-making positions.
The future of public health education: the post Covid-19 era
Authors: Magaña-Valladares Laura , Penniecook Tricia
Published: January 2023

The Covid-19 pandemic revealed once again the unsustainable social inequities that resulted in a disproportionate number of illnesses and deaths among different social groups. Public health must take its leading role in public policy to advance the social determinants that affect the health and well-being of populations. Public policy and the workforce must continue to prioritize population’s wellbeing and health equity by challenging the status quo. Thus, it is a pressing necessity to evolve and transform public health education by developing and integrating the culture of agile change, embracing structural transformations and shifting to a lifelong learning approach. The paradigm shift in public health education should emphasize interprofessional and intersectoral approaches, the development of human and social competencies, a lifelong learning perspective and the implementation of new pedagogical and technological strategies. A holistic curricular approach which highlights the importance of public policy and the right to health and social justice should also be emphasized. This transformation must occur taking into account/considering faculty development, investment in technology, flexibility for accreditation, and collaboration with employers in various sectors. Public health education must evolve in order to remain relevant and adequately prepare and equip the leaders and practitioners that the world requires. The current crisis is an opportunity to renew and redefine public health education.
Five deficits to tackle by the future public health education
Authors: Santos-Burgoa Carlos
Published: January 2023

Not available
The future of public health education and research
Authors: Rosenberg Felix
Published: January 2023

Not available
Application of Data-Mining Algorithms to Parameterize Static and Dynamic Models
Authors: Kayode Babatope O , Stephen Karl D , Kaba Abdullah
Published: January 2023

Many field development plans leverage integrated reservoir studies (IRS) involving static modeling, dynamic modeling, and forecasts. Porosity and permeability fields are distributed in static models using probabilistic approaches such as sequential Gaussian simulation. The static model also requires petrophysical rock types (PRTs) and saturation-height function (SHF), which are parameters derived from mercury-injection-capillary-pressure (MICP) data. This study presents the application of data mining algorithms for deriving useful parameters to constrain static and dynamic models and to derive PRT and SHF from non-MICP sources.

The paper presents the application of multivariate Gaussian regression for anomaly detection and filtering of core, log, and pressure data to rapidly eliminate outliers or incorrect values within a modeling dataset. We used a fixed window statistics algorithm to detect the intra-reservoir architecture (IRA) from the core permeability. The k-means clustering algorithm determined the PRT and SHF from core permeability and water saturation logs. Finally, a pattern recognition algorithm clustered the observed datum pressures into homogeneous groups and created a reservoir heterogeneity map to use as an input in the 3D permeability modeling. This study used data extracted from a hypothetical 3D model that distributes porosity and permeability using a sequential Gaussian simulation. The study defined the PRTs as functions of porosity and permeability using Winland's R35 equation and defined the SHFs for various PRTs to populate the water saturation in the hypothetical model. It assumed the hypothetical model as the truth model and subsequently defined several wells randomly in the truth model to obtain the porosity, permeability, water saturation, and PRT logs. This study obtained the observed datum pressures using a dynamic simulation of the truth model over a few years.

We presented a new diagnostic plot that works with the traditional semi-log plot of porosity and permeability. This new diagnostic plots the semi-log of the global set of core permeability versus depth. We used the plot to obtain IRA by calculating the arithmetic mean permeability over every 1ft thickness and defining its boundaries of stationarity. The PRT and SHF derived from the k-means clustering were sufficiently similar to the truth model results. Anomaly filtering of the global pressure set helped detect data outliers that may have gone unnoticed.

The data mining algorithms presented in this study could help obtain the PRT and SHF to complement Winland's interpretation when mercury injection capillary pressure (MICP) experiments are limited or unavailable, saving time and cost. Using IRA and reservoir heterogeneity maps in the static modeling process could produce a statistically and phenomenologically representative model, requiring limited history-matching intervention. To our knowledge, this is the first study to map the IRA of a reservoir using core data.
Generation of cell lines for the usage of Intron-encoded Scarless Programmable Extranuclear Cistronic Transcripts (INSPECT)
Authors: TRUONG Dong-Jiunn Jeffery , Armbrust Niklas , Geilenkeuser Julian , Westmeyer Gil Gregor
Published: January 2023

Despite their pivotal role in evaluating (patho)physiological cell states, traditional gene reporters can follow gene expression but leave marks on proteins or significantly modify mature mRNA. Multi-time point readouts of non-coding RNAs are, to date, not applicable without changing their nucleotide sequence, which may affect their natural function, half-life, and localization. We thus created INSPECT (Intron-encoded Scarless Programmable Extranuclear Cistronic Transcripts) as a minimally invasive transcriptional reporter nested within an intron of a gene of interest. Post-transcriptional excision of INSPECT results in a mature RNA with no sequence changes and an additional synthetic transcript that leaves the nucleus by hijacking the nuclear host export machinery for cytosolic translation into a reporter protein. Here, we first illustrate the cloning of such an INSPECT DNA donor construct and an auxiliary CRISPR/Cas9 plasmid to insert INSPECT into a gene of interest and, secondly, exemplary for NEAT1_long, we showed the generation of such a cell line.
Control of nonlinear bulk deformation and large shear strain on first-order phase transformation kinetics
Authors: Utkin Ivan , Schmalholz Stefan Markus , Podladchikov Yury
Published: January 2023

Phase transformations play a key role for many coupled natural processes and they are important for many industrial applications. However, the kinetics of phase transformations taking place in coupled chemo-mechanical systems undergoing large mechanical deformations still need to be better quantified. Here, we study phase transformation kinetics for two phases having each two chemical components. We couple a Cahn-Hilliard type model with a mechanical model for compressible viscous flow. The bulk compressibility is a nonlinear function of the pressure and the shear viscosity is a nonlinear function of the concentration. The mechanical coupling is done by considering a pressure-dependent mechanical mixing term in the equation for the Gibbs energy. We derive a dimensionless system of equations which we solve numerically with a pseudo-transient method using conservative finite differences for discretisation. We perform 1D and 2D numerical simulations and consider far-field simple shear and pure shear. For a chemo-mechanically coupled system, we show that the velocity of the phase boundary is a linear function of the degree of metastability and, hence, confirm the hypothesis of “normal growth”. A stronger mechanical coupling and a larger volumetric effect of the chemical reaction cause slower phase boundary velocities. The 2D results show a significant impact of the mechanical coupling and the far-field deformation on the orientation and kinetics of the phase transformations. Under far-field simple shear and pure shear, the phase transformations generate string-like patterns. The orientation of these patterns is controlled by the applied far-field deformation and orientations differ by 45 degrees between simple shear and pure shear.
Uncertain Chinese Postman Problem with Budget Constraint: A Robust Optimization Approach
Authors: Das M. , Nahak Chandal , Biswal M.P.
Published: January 2023

The Chinese postman problem (CPP) is a well-known combinatorial optimization problem, that is used in various real-world applications. Modeling such real-world applications frequently necessitates taking into account some uncertain variables. Robust optimization is one of the prominent approach to solves optimization problems when there is uncertainty in the parameters of the optimization problem. In this paper, we study uncertain multi-objective Chinese postman problem with budget constraint by maximizing profit and minimizing time under the light of robust optimization theory. We formulate the deterministic form of uncertain multi-objective CPP for three different types of uncertainty sets like ellipsoidal, polyhedral and budgeted uncertainty sets. The models are then solved using two well-known multi-objective solution strategies: the global criteria approach and the fuzzy programming method. Finally, numerical experiment are made through the models.
MSC Classification: 90C17 , 90C05 , 90C90
Evidential Reasoning Rule for Environmental Governance Cost Prediction with Considering Causal Relationship and Data Reliability
Authors: Ye Fei-Fei , Yang Long-Hao , Uhomoibhi James , Liu Jun , Wang Ying-Ming
Published: January 2023

The authors have requested that this preprint be removed from Research Square.
A Variance Difference Method for Determining Optimal Number of Clusters in Wireless Sensor Networks
Authors: S Girija M , R Tapas Bapu B , D Magesh Babu
Published: January 2023

Sensor networks are frequently employed to keep an eye on rapidly changing, dynamic environments. Low latency, energy efficiency, coverage difficulties, and network lifetime are seen to be the most important problems in wireless sensor networks. Cluster-based wireless sensor networks require additional study to overcome issues with energy efficiency and network lifespan. Finding the ideal number of clusters with the goal of reducing energy consumption is one of the primary challenges in cluster-based networks. The right value for k relies on the shape and size of the point distribution in a data collection, as well as the user's preferred level of clustering resolution. Additionally, if each data point is taken into account as its own cluster, increasing k without suffering any penalties diminishes the degree of accuracy in the resulting clustering until it reaches zero. Hence, Variance Difference Method (VDM) is proposed in order to determine the ideal number of clusters K and to carry out clustering in WSN. Elbow method, Silhouette method, and Gap statistic method performance is also reviewed and contrasted with that of the suggested VDM in order to demonstrate that the proposed VDM performs better than Elbow method, Silhouette method, and Gap Statistic method.
Impacts of a weakened AMOC on precipitation over the Euro- Atlantic region in the EC-Earth3 climate model
Authors: Bellomo Katinka , Meccia Virna L. , D’Agostino Roberta , Fabiano Federico , Larson Sarah M. , von Hardenberg Jost , Corti Susanna
Published: January 2023

Given paleoclimatic evidence that the Atlantic Meridional Overturning Circulation (AMOC) may affect the global climate system, we conduct model experiments with EC-Earth3, a state-of-the-art GCM, to specifically investigate, for the first time, mechanisms of precipitation change over the Euro-Atlantic sector induced by a weakened AMOC. We artificially weaken the strength of the AMOC in the model through the release of a freshwater anomaly into the Northern Hemisphere high latitude ocean, thereby obtaining a ~ 57% weaker AMOC with respect to its preindustrial strength for 60 model years. Similar to prior studies, we find that Northern Hemisphere precipitation decreases in response to a weakened AMOC. However, we also find that the frequency of wet days increases in some regions. By computing the atmospheric moisture budget, we find that intensified but drier storms cause less precipitation over land. Nevertheless, changes in the jet stream tend to enhance precipitation over northwestern Europe. We further investigate the association of precipitation anomalies with large-scale atmospheric circulations by computing weather regimes through clustering of geopotential height daily anomalies. We find an increase in the frequency of the positive phase of the North Atlantic Oscillation (NAO+), which is associated with an increase in the occurrence of wet days over northern Europe and drier conditions over southern Europe. Since a ~ 57% reduction in the AMOC strength is within the inter-model range of projected AMOC declines by the end of the 21st century, our results have implications for understanding the role of AMOC in future hydrological changes.
The Challenges in Neurosurgery during the COVID-19 pandemic: a systematic review
Authors: Teng Haiying , Wang Zilan , Yang Xingyu , Wu Xiaoxiao , Chen Zhouqing , Wang Zhong , Chen Gang
Published: January 2023

Background
The coronavirus disease-2019 (COVID-19) pandemic has created a global crisis unique to the health care system around the world. It also had a profound impact on the management of neurosurgical patients. In our research, we intended to investigate the effect of COVID-19 pandemic on neurosurgery, particular including vascular and oncological neurosurgery.
Method
Two investigators independently and systematically searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL) to identify relevant studies respecting the criteria for inclusion and exclusion published up to June 30th, 2022. The outcomes of our research including mortality rate, length of stay, modified Rankin Score, delay in care, Glasgow outcome scale and major complications.
Results
Two investigators independently and systematically searched 1270 results from PubMed, Embase, Cochrane database, and extracted the detailed data from 13 articles assessed for eligibility, including 2 intracerebral hemorrhage, five subarachnoid hemorrhage, two neuro-oncology and 2 unspecified neurosurgery. A total of 25,864 patients were included in our research.
Conclusion
Some of our included studies suggested that pandemic caused negative effect on the outcomes of neurosurgery while others suggested that the pandemic didn't cause significant effect on the neurosurgery. Meanwhile, the effect of pandemic on neurosurgery may differ from different region.
Routines for the synthesis of carbyne with more than 6000 atoms
Authors: Wong Chi Ho , Yeung Yan Ming , Zhao Xin , Law Wing Cheung , Tang CY , Mak Chee Leung , Leung Chi Wah , Lortz Rolf
Published: January 2023

The superior electronic, optical and magnetic properties of the one-dimensional carbyne are of high technological relevance for the development of future optoelectronic and magnetoelectronic applications. However, the production of a monoatomic chain with more than 6000 carbon atoms is an enormous technological challenge. To predict the exact growth conditions and in particular the optimal chain length of a carbyne fibre in different molecular environments, we have developed a Monte Carlo model in which a finite-length carbyne with a size of 4000-15000 atoms is encapsulated by a carbon nanotube at finite temperature. Our simulation shows that the stability of the carbyne-nanotube is strongly influenced by the nature and porosity of the carbon nanotube, the external pressure, the temperature and the chain length. When the exact geometric structure of the carbon nanotube and the environmental parameters are provided as input, our simulation can predict the optimal length of the encapsulated carbyne. We have found four mechanisms of triggering chain breakage and have predicted the probable size of the carbyne fragments in excited states. Our work provides much needed input for optimising the carbyne length to produce carbon chains much longer than 6000 atoms at room temperature.
What is the evidence of how hospitals capture financial benefits of process improvement and does it impact hospital financial performance?: A systematic review
Authors: Evans Jane , Leggat Sandra , Samson Danny
Published: January 2023

Title
What is the evidence of how hospitals capture financial benefits of process improvement and does it impact hospital financial performance?: A systematic review
Background
Hospitals managers around the world are looking for ways to address the continual growth in expenditure by reducing the level of waste in the healthcare delivery system and improving the value of care provided to patients. Process improvement methods are being applied to increase high value care, reduce low value care and remove waste from care processes.
The purpose of this study is to establish whether hospitals can measure and capture the financial benefits of process improvement (PI) through reducing process and clinical care waste and improving the value of care.
Methods
A systematic review was undertaken that followed the PRISMA process and employed qualitative research methods.
Results
Only six papers that reported a reduction in care process waste or improvement of the value of care using an evidence based PI approach and included financial benefits analysis were identified through the systematic review. In these papers, a positive financial impact was measured for the PI initiatives but none of the studies reported how the financial benefits were captured or applied to the enterprise level. Three of the studies suggested that sophisticated cost accounting systems were required to enable this.
Conclusion
The study demonstrates the paucity of literature in the field of PI and financial benefits measurement in healthcare. Where financial benefits are documented, they vary in terms of cost inclusions and the ‘level’ at which the costs were measured.
Further research on best practice financial measurement methods is needed to enable other hospitals to measure and capture financial benefits arising from their PI programs.
Development of Core Outcome Sets of Food for Special Medical Purposes designed for type 2 diabetes mellitus: a study protocol
Authors: Mu Dongyu , Gong Jie , Wei Yaoyao , Chen Muxi , Yu Jiajie , Du Liang , Hu Wen
Published: January 2023

Background

The Chinese government stipulates all Food for Special Medical Purposes (FSMP) designed for specific diseases to be tested in clinical trials before approving it for registration. The process of developing core outcome sets (COSs), the minimum sets of outcomes supposed to be measured and reported, provides an economical and practical option for stakeholders to communicate and cooperate in conducting clinical trials as well as in reporting FSMP outcomes. This study uses type 2 diabetes mellitus (T2DM) as an example to develop COS for clinical trials of FSMP.

Methods

The COS for FSMP-T2DM will be divided into 3 phases and developed following COS-STAP and COS-STAD:
(1) Generate a list of relevant outcomes identified from a systematic review, in which information sources will mainly include published studies, regulatory documentation, and qualitative interviews of stakeholders. The identified outcomes will be categorized using a conceptual framework and formatted into the first round of the Delphi survey questionnaire items.
(2) At least 2 rounds of Delphi surveys will be performed among stakeholders to create the COS for FSMP-T2DM. Patients, clinical dietitians, physicians, COS researchers, journal editors, FSMP manufacturers, and regulatory representatives will be invited to score each outcome from aspects of importance.
(3) Hold a face-to-face or online consensus meeting to refine the content of the COS for FSMP-T2DM. Key stakeholders will be invited to attend the meeting to discuss and agree on the final COS.

Discussion

We have prepared an alternative solution of the Likert scale selection, Delphi survey rounds, scoring group, and consensus definitions in case of an unexpected situation.

Trial registration

COMET (1547).
Evaluation of a Point-of-care ultrasound (POCUS) workshop for peripheral intravenous cannulation
Authors: Steinwandel Ulrich , Coventry Linda , Kheirkhah Homa
Published: January 2023

Background:
Point-of-care ultrasound (POCUS) is increasingly used as a non-invasive vascular access assessment method by clinicians from multiple disciplines worldwide, prior and during vascular access cannulations. While POCUS is a relatively new method to establish a vascular access in patients with complex vascular conditions, it is also essential to train and educate individuals who are novices in the techniques of cannulation so that they become proficient in performing this task subsequently on patients safely and successfully. A simulated environment may be a helpful tool to help healthcare providers establish skills in using POCUS safely and may also help them to successfully establish vascular access in patients. With this project, we sought to determine if participants of a simulated POCUS workshop for vascular access can use this technique successfully in their individual clinical environment after their attendance of a half-day workshop.
Methods:
A mixed-methods longitudinal study design was chosen to evaluate a point-of-care ultrasound workshop for peripheral intravenous cannula insertion. The workshops used simulation models for cannulation in combination with multiple ultrasound devices from various manufacturers. Participants self-assessed their cannulation skills using questionnaires prior to and directly after the workshop.
Results:
A total of 85 Individuals participated in eleven half-day workshops through 2021 and 2022. Workshop participants claimed that attending the workshop had significantly enhanced their clinical skill of using ultrasound for the purpose of cannulating a venous vessel. The level of confidence in using this technique had increased in all participants directly after conclusion of the workshop.
Conclusions:
Globally, clinicians are increasingly using POCUS to establish vascular access in patients, and it is necessary that they receive sufficient and adequately structured and formal training to successfully apply this technique in their clinical practice. Offering a workshop which uses simulation models in combination with various POCUS devices to demonstrate this technique in a hands-on approach has proven to be useful to establish this newly learned skill in clinicians.
Impact of the Russia-Ukraine war on global food security: Food affordability under pressure
Authors: Meijl Hans , Bartelings Heleen , Berkum Siemen van , Cui David , Kristkova Zuzana , Zeist Willem-Jan van
Published: January 2023

The Russian invasion of Ukraine has the potential to exacerbate food insecurity around the world as both countries are major exporter of grains and other agricultural products. In this model-based scenario study, medium-term effects of the war on agricultural production, trade flows, market prices, and food security are quantified. The scenarios focus on the possible consequences of macro-economic and agricultural production impacts in Ukraine, consequences of trade sanction measures against Russia, and related higher energy prices. From a food security perspective, we conclude that there is enough food on the global level, but higher food prices could become a problem for a part of the population that has a low income and spends a large part of their food on cereals. For some countries highly dependent on imports of Ukrainian and Russian cereals like Egypt and Turkey, food availability will come under some pressure.
Drought Stress Alters Photosynthetic and Carbohydrate-related Proteins in Leaves of Banana
Authors: Lau Su-Ee , Pua Teen-Lee , Saidi Noor Baity , Abdullah Janna Ong , Lamasudin Dhilia Udie , Tan Boon Chin
Published: January 2023

Drought is the most prominent limiting factor to crop productivity, posing a severe threat to food security. However, how plants respond to drought stress and post-drought recovery remains unclear. Therefore, this study determined the morphological and protein responses of banana plants (Musa acuminata cultivar Berangan) affected by drought stress, followed by water recovery. The results showed that drought significantly reduced the leaf area, plant height, fresh weight, stem circumference, leaf relative water content, chlorophyll contents, and root length of the bananas. In contrast, relative electrolyte leakage, proline, malondialdehyde (MDA) and hydrogen peroxide contents, and the activities of antioxidant enzymes, including catalase (CAT), ascorbate peroxidase (APX), glutathione reductase (GR), peroxidase, and superoxide dismutase, were induced in the drought-treated banana leaves. However, the relative water content, MDA and hydrogen peroxide contents, and antioxidant enzyme activities, including CAT, APX, and GR, were comparable with well-watered plants after water recovery. Changes in the protein content between well-watered, drought-stressed, and recovered banana plants were determined using tandem mass tags (TMT)-based quantitative proteomics. Of the 1,018 differentially abundant proteins, 274 were significantly changed. The identified proteins differing between the treatments were mainly related to carbohydrate, energy and amino acid metabolisms, genetic information processing, and secondary metabolite biosynthesis. Our data may assist in developing a complete proteome dataset which could be valuable for developing drought-tolerant bananas.
Functional analysis of a putative HER2-associated expressed enhancer, Her2- Enhancer1, in breast cancer cells
Authors: Rojhannezhad Mahdieh , Soltani Bahram M. , Vasei Mohammad , Ghorbanmehr Nassim , Mowla Seyed Javad
Published: January 2023

HER-2/neu (HER2) is a member of epidermal growth factor receptors (EGFR) family, encoding a protein with tyrosine kinase activity. Following the gene amplification or increased HER2 transcription, carcinogenesis has been observed in some cancers. Genetic and epigenetic changes occurring in enhancer sequences can deeply affect the expression and transcriptional regulation of downstream genes, which can cause some physiological and pathological changes, including tumor progression. A therapeutic approach that directly targets the genomic sequence alterations is of high importance, with low side effects on healthy cells. Here, we employed the CRISPR/Cas9 method to genetically knockout an expressed putative enhancer (GH17J039694; we coined it as Her2-Enhancer1) located within the HER2 gene, 17q12: 39694339–39697219 (UCSC-hg38). We then investigated the potential regulatory effect of Her2-Enhancer1 on HER2 and HER2-interacting genes. In order to evaluate the cis and trans effects of Her2-Enhancer1, genetic manipulation of this region was performed in HER2-positive and -negative breast cancer cells. Our bioinformatics and real-time PCR data revealed that this putative enhancer region is indeed expressed, and act as an expressed enhancer. Further functional analysis on edited and unedited cells revealed a significant alteration in the expression of HER2 variants, as well as some other target genes of HER2. Moreover, apoptosis rate was considerably elevated within the edited cells. As we expected, Western blot analysis confirmed a reduction in protein levels of HER2, GRB7, the gene interacting with HER2, and P-AKT in PI3K/AKT pathway. Altogether, our findings revealed an enhancer regulatory role for Her2-Enhancer1 on HER2 and HER2-interacting genes; and that this region has a potential for targeted therapy of HER2-positive cancers.
Automatic stridor detection using small training set via patch-wise few-shot learning for diagnosis of multiple system atrophy
Authors: Ahn Jong Hyeon , Lee Ju Hwan , Lim Chae Yeon , Joo Eun Yeon , Youn Jinyoung , Chung Myung Jin , Cho Jin Whan , Kim Kyungsu
Published: January 2023

Stridor is a rare but important non-motor symptom that can support the diagnosis and prediction of worse prognosis in multiple system atrophy. Recording sounds generated during sleep by video-polysomnography is recommended for detecting stridor, but the analysis is labor intensive and time consuming. A method for automatic stridor detection should be developed using technologies such as artificial intelligence (AI) or machine learning. However, the rarity of stridor hinders the collection of sufficient data from diverse patients. Therefore, an AI method with high diagnostic performance should be devised to address this limitation. We propose an AI method for detecting patients with stridor by combining audio splitting and reintegration with few-shot learning for diagnosis. We used video-polysomnography data from patients with stridor (19 patients with multiple system atrophy) and without stridor (28 patients with parkinsonism and 18 patients with sleep disorders). To the best of our knowledge, this is the first study to propose a method for stridor detection and attempt the validation of few-shot learning to process medical audio signals. Even with a small training set, a substantial improvement was achieved for stridor detection, confirming the clinical utility of our method compared with similar developments. The proposed method achieved a detection accuracy above 95% using data from only eight patients with stridor for training. Performance improvements of 4%--13% were achieved compared with a state-of-the-art AI baseline. Moreover, our method determined whether a patient had stridor and performed real-time localization of the corresponding audio patches, thus providing physicians with support for interpreting and efficiently employing the results of this method.
Boron Nitride-enabled Printing of Highly Sensitive and Flexible Iontronic Pressure Sensing System toward Spatial Mapping
Authors: Gao Libo , Yang Zekun , Duan Qikai , Zang Junbin , Zhao Yunlong , Zheng Weihao , Xiao Ran , Zhang Zhidong , Hu Liangwei , Wu Guirong , Nan Xueli , Xue Chenyang
Published: January 2023

Flexible iontronic pressure sensors (FIPS) with high sensitivity and wide sensing range compared to conventional capacitive sensors have recently been widely investigated. However, mainly due to the difficulty of fabricating nanostructures commonly used on electrodes or ionic layers by screen printing techniques, strategies to fabricate such devices using screen printing techniques to drive their mass production have been rarely reported. Here, for the first time, we employed the 2-dimensional (2D) material and hexagonal boron nitride (h-BN) as an additive and ionic liquid reservoir into the ionic film, which not only can make it printable but also significantly improve the sensor’s sensitivity and sensing range through screen printing. The engineered sensor exhibited high sensitivity (Smin> 261.4 kPa− 1) and broad sensing range (0.05–450 kPa) and is capable of stable operation at high pressure (400 kPa) for more than 5000 cycles. In addition, the integrated sensor array system allows accurate monitoring of wrist pressure and shows great potential for healthcare systems. We believe the concept of using h-BN as an additive into the ionic material for screen-printed FIPS would greatly inspire other research using 2D materials for similar such systems and other types of sensors.
Wilms tumor 1 associated protein promotes metastasis and chemo-resistance to oxaliplatin by nuclear factor kappa B pathway in gastric cancer
Authors: Liu Yu , Li Weidong , Yang Jian , Ma Weijun , Fan Chuanlei , Da Mingxu
Published: January 2023

Background
There is now substantial evidence that epigenetic modifications largely contribute to gastric carcinogenesis and metastasis, causing a large number of tumor-related deaths. N6-methyladenosine(m6A) is a modification that adds a methyl group at the N6 position, and Wilms tumor 1 associated protein (WTAP) is an important methylase of m6A. WTAP has been reported to play a role in a variety of tumors.
Results
In the present study, we found that WTAP was highly expressed in gastric cancer (GC) tissues and cells and promoted migration/invasion of GC cells. WTAP promoted the expression of B-cell lymphoma-2(bcl-2), inhibited the expression of Bax, increased the protein levels of p-IKKα, p65, p-p65 and p-IκBα, promoted the expression of nuclear factor kappa B (NF-κB) pathway, and mediated the resistance of GC cells to the chemotherapeutic drug oxaliplatin (OPX). Interestingly, the NF-κB pathway-specific inhibitor caffeic acid phenethyl ester (CAPE) eliminated OPX resistance generated by WTAP overexpression cells and essentially reduced it to the level of resistance in their control cells.
Conclusions
In summary, the WTAP/NF-κB/bcl-2 pathway may be critical in promoting GC cell proliferation and OPX resistance development, providing a potential therapeutic target for GC treatment.
An in-Silico Study of the Distribution of Mn Oxidation Proteins in Sequenced Bacterial Genomes
Authors: Kurdi M. Zakaria , Olichney Jacob , Geszvain Kati
Published: January 2023

While many species of bacteria have been identified that can convert soluble, reduced manganese (Mn+2) into insoluble, oxidized Mn+4 oxides, the mechanisms these bacteria employ and their distribution throughout the bacterial domain are less well understood. Laboratory-based studies identified three Mn oxidase enzymes in Pseudomonas putida GB-1 (PpMnxG, McoA and MopA), one in Bacillus sp. PL-12 (BaMnxG), and one in Leptothrix discophora sp SS-1 (MofA).
By querying public databases of bacterial genome sequences for homologs to these Mn oxidase proteins, it was possible to determine the distribution of these proteins within bacteria. Most homologs were found in just three phyla: proteobacteria, actinobacteria and firmicutes. Each of the homologs had a statistically significant probability of being present as the solo Mn oxidase in a genome. When genomes did have more than one oxidase, they were present in the same combinations as in P. putida GB-1. These results do not support the initial hypothesis that multiple enzymes are required to complete the two-electron oxidation of Mn+2 to Mn+4. Alternatively, the various Mn oxidase enzymes may be optimized to function under different environmental conditions; organisms like P. putida GB-1 may need to oxidize Mn at different temperatures, nutritional states or oxygen conditions.
Time to Bridge the Gap between Accounting and Technology through Improving the Accounting Curriculum: A Perceptional View
Authors: Divyashree M S , N Abhishek , Kulal Abhinandan , Kanchan Swarn G
Published: January 2023

Today there are many advancements in accounting practices across the globe. But the accounting curriculum in the higher education institutions of India are still out dated. This in turn indirectly impacting on the transversal competencies of accounting graduates. Therefore, in the present study the opinions from academicians and professionals are gathered on the cuurent status of accounting education in India and the collected opinions are analyzed through independent samples t-test and concluded that higher education institutions in India needs to redesign accounting curriculum in par with professional educational curriculum like professionals education curriculum followed by professional institutes such as ICAI, ICSI, ICWA and IIMs at large.
The effect of health ambassadors’ training based on social cognitive theory on brucellosis preventive behaviors in rural areas: Randomized controlled trial
Authors: Khosraviasl Tahereh , Moshki Mahdi , Dogonchi Mitra
Published: January 2023

Background: Brucellosis is still a serious public health threat and an endemic disease in Iran. Despite eradication programs, it is a major challenging issue for human health. This study examined the effect of health ambassadors’ training based on social cognitive theory on brucellosis preventive behaviors in rural areas.
Methods: This study was conducted as a randomized controlled trial. The intervention program was performed in two steps. Step 1: Training of health ambassadors by the researcher and Step 2: Training of village residents by health ambassadors.120 residents of rural areas of Mashhad were selected from two villages using two-stage random sampling and were assigned to two intervention and control groups.
Results: The mean age of the participants in the intervention group was 33.9±90.97 years. There was a statistically significant difference between the mean scores of constructs of knowledge, outcome expectations, outcome value, self-efficacy, self-efficacy in overcoming obstacles, self-regulation, emotional adjustment, and behavior measurement after the intervention compared to before intervention(p <0.0001).
Conclusion: The results indicated that training programs based on SCT can be effective in improving brucellosis preventive behaviors. The training interventions that are designed to educate health ambassadors and villagers using social cognitive theory with a focus on individual, cognitive, environmental, and behavioral factors can improve behaviors that prevent brucellosis.
Trial registration:
This trial has been registered by the title of “The effect of health ambassadors’ training based on social cognitive theory on brucellosis preventive behaviors in rural areas: a randomized control trial” in the Iranian Registry of Clinical Trials (IRCT) with code “I IRCT20220204053935N1”, https://www.irct.ir/trial/47529. The registration date is May 18, 2022.
Data-driven adjoint-based calibration of port-Hamiltonian systems in time domain
Authors: Günther Michael , Jacob Birgit , Totzeck Claudia
Published: January 2023

We present a gradient-based calibration algorithm to identify the system matrices of a linear port-Hamiltonian system from given input-output time data. Aiming for a direct structure-preserving approach, we employ techniques from optimal control with ordinary differential equations and define a constrained optimization problem. The input-to-state stability is discussed which is the key step towards the existence of optimal controls. Further, we derive the first-order optimality system taking into account the port-Hamiltonian structure. Indeed, the proposed method preserves the skew-symmetry and positive (semi)-definiteness of the system matrices throughout the optimization iterations. Numerical results with perturbed and unperturbed synthetic data, as well as an example from the PHS benchmark collection demonstrate the feasibility of the approach.
AMS classification: 37J06, 37M99, 49J15, 49K15, 49M29, 49Q12, 65P10, 93A30, 93B30, 93C05
Paradoxical contralateral hemiparesis in spontaneous spinal epidural hematoma: A case report
Authors: Okada Kazuhiro , Fujita Youshi , Kitai Ryuhei
Published: January 2023

Background: Hemiparesis associated with spontaneous spinal epidural hematoma (SSEH) usually occurs ipsilateral to the hematoma. We here report the case of a patient with paradoxical hemiparesis contralateral to a spinal lesion due to SSEH.
Case presentation: A 70-year-old woman was identified in routine clinical practice; she presented with acute-onset neck pain and left hemiparesis. Neurological examination showed left-sided sensory-motor hemiparesis without facial involvement. Cervical MRI showed a dorsolateral epidural hematoma compressing the spinal cord at the C2 to C3 level. Axial imaging demonstrated a crescent hematoma on the right side, which is contralateral to the hemiparesis, and lateral displacement of the spinal cord. Spinal angiography revealed no abnormal vessels. Based on clinical presentation and MRI findings, a diagnosis of SSEH was made. The patient was managed conservatively. The symptoms completely resolved without any neurological deficits, and the hematoma disappeared on the follow-up MRI.
Conclusions: Paradoxical contralateral hemiparesis is one of the possible presenting symptoms in patients with SSEH. This case demonstrates the existence of the paradoxical contralateral hemiparesis associated with spinal compressive lesions. A plausible mechanism of the phenomenon is discussed.