bluuebunny/crossref_metadata_2025 huggingface dataset:
Complete Genome Sequence of
Microbacterium
sp. Strain 10M-3C3, Isolated from an Extremely Phosphorus-Poor Lake
Authors: Hempel Priscilla , Keffer Jessica L. , Shevchenko Olga , Henny Cynthia , Polson Shawn W. , Maresca Julia A.
Published: January 2019

Here, we report the complete genome sequence of
Microbacterium
sp. strain 10M-3C3, which was isolated from Lake Matano, Indonesia. The genome is 3,387,846 bp long, encodes 3,351 predicted proteins, and has a G+C content of 71.6%.
Anaphylaxis to patent blue dye in a 17-year-old boy
Authors: Leung Mélanie , McCusker Christine , Ben-Shoshan Moshe
Published: January 2019

Patent blue V dye (PBV) is frequently used as a perioperative drug for lymphangiography, as well as a food additive. Hypersensitivity to PBV is poorly documented in adults and had not been previously described in children. The diagnosis of PBV allergy depends on corroboration of history consistent with an IgE-mediated reaction and confirmatory skin tests. We present in this paper a paediatric case of PBV anaphylaxis and of biphasic reaction that exemplifies the challenges involved in diagnosing and managing this rare but potentially life-threatening allergic reaction.
ARS2 is required for retinal progenitor cell S-phase progression and Müller glial cell fate specification
Authors: O’Sullivan Connor , Nickerson Philip E.B. , Krupke Oliver , Christie Jennifer , Chen Li-Li , Mesa-Peres Monica , Zhu Minyan , Ryan Bridget , Chow Robert L. , Howard Perry L.
Published: January 2019

During a developmental period that extends postnatally in the mouse, proliferating multipotent retinal progenitor cells produce one of 7 major cell types (rod, cone, bipolar, horizontal, amacrine, ganglion, and Müller glial cells) as they exit the cell cycle in consecutive waves. Cell production in the retina is tightly regulated by intrinsic, extrinsic, spatial, and temporal cues, and is coupled to the timing of cell cycle exit. Arsenic-resistance protein 2 (ARS2, also known as SRRT) is a component of the nuclear cap-binding complex involved in RNA Polymerase II transcription, and is required for cell cycle progression. We show that postnatal retinal progenitor cells (RPCs) require ARS2 for proper progression through S phase, and ARS2 disruption leads to early exit from the cell cycle. Furthermore, we observe an increase in the proportion of cells expressing a rod photoreceptor marker, and a loss of Müller glia marker expression, indicating a role for ARS2 in regulating cell fate specification or differentiation. Knockdown of Flice Associated Huge protein (FLASH), which interacts with ARS2 and is required for cell cycle progression and 3′-end processing of replication-dependent histone transcripts, phenocopies ARS2 knockdown. These data implicate ARS2–FLASH-mediated histone mRNA processing in regulating RPC cell cycle kinetics and neuroglial cell fate specification during postnatal retinal development.
Decoupling of otolith and somatic growth during anadromous migration in a northern salmonid
Authors: Morrison Christie M. , Kunegel-Lion Mélodie , Gallagher Colin P. , Wastle Rick J. , Lea Ellen V. , Loewen Tracey N. , Reist James D. , Howland Kimberly L. , Tierney Keith B.
Published: January 2019

We assessed the fish length – otolith length relationship (FL–OL) in Dolly Varden (Salvelinus malma malma) to verify proportional growth. A decoupling was detected during first ocean migration where fish growth was occurring at a greater rate than otolith growth. Because of this decoupling, the application of traditional back-calculation models overestimated the size-at-age in premigratory char. We developed modified back-calculation equations from existing traditional models to account for this decoupling based on discontinuous piecewise regressions. The new biological intercept breakpoint method (BI–BP) provided the most accurate representation of fish size-at-age throughout all life history stages when compared with known size-at-capture values in fish. The decoupling indicates that factors other than somatic growth are important for otolith accretion. Physiological changes during smoltification likely alter calcium uptake and thereby affect calcium deposition rates on otoliths during this short but biologically critical time period of life history. It is probable that species exhibiting similar complex ontogenetic shifts in life history will likely exhibit decoupling to some extent in the FL–OL relationship.
Assessment of nitrification and urease inhibitors on nitrate leaching in corn (Zea mays L.)
Authors: Pawlick Amy A. , Wagner-Riddle Claudia , Parkin Gary W. , Berg Aaron A.
Published: January 2019

Agricultural ecosystems are one of the largest global contributors to nitrate (NO3−) contamination of surface- and groundwater through fertilizer application. Improved fertilizer practices are needed to manage crop nutrient supply in corn (Zea mays L.) while minimizing impacts to clean water reserves. The goal of this study was to compare current nitrogen (N) fertilizer practices (urea at planting) with “packages” of improved management practices (a combination of right timing and product) that farmers potentially use. We conducted measurements in a continuous corn system from November 2015 to May 2017 at a large field scale (four 4 ha plots). Nitrate concentration was measured below the root zone and drainage estimated using a soil water budget approach in which evapotranspiration was measured using the eddy covariance method. The objective was to compare NO3−-N leaching from fields receiving urea vs. urea + combination of nitrification and urease inhibitors (NUI) fertilizer applications at planting, urea–ammonium nitrate (UAN) vs. UAN + NUI applied at sidedress, and a combination of these practices: urea + NUI at planting vs. UAN at sidedress. Drainage was only significant in the non-growing season. Neither fertilizer products applied with NUI at planting or sidedress proved to significantly reduce NO3−-N leaching. The combination of delaying fertilization to sidedress and applying UAN significantly reduced the soil water NO3−-N concentration compared with urea + NUI at planting (mean of 5.2 vs. 6.7 mg L−1) but only in 2015–2016. Based on these results, applying UAN at sidedress is recommended, although additional study years are needed to confirm those results.
Impact of drainage type on simultaneous nitrogen losses in Atlantic Canada
Authors: Smith Erin L. , Vosman Amanda , Kellman Lisa , Rodd Vernon
Published: January 2019

Nitrogen (N) losses from agricultural tile drainage systems are environmental and economic losses for producers. This field study quantified N losses from three reps of shallow (SD), deep/conventional (DD), and controlled drainage (CD) on farmland in Nova Scotia. Drainage systems were under corn and alfalfa–oats–clover production. Outflow water and gas samples were obtained and analyzed for nitrate and nitrous oxide. Nitrate-N loads were 5.0, 11.1, and 6.4 kg ha−1 in 2015; 1.8, 6.7, and 2.8 kg ha−1 in 2016; and 0.74, 1.8, and 1.6 kg ha−1 in 2017 for SD, DD, and CD, respectively. Controlled drainage reduced NO3−-N loading by 42.3%–58.2% when compared with the conventional/DD in 2 of 3 yr of study, whereas SD was found to reduce NO3−-N loading by 54.9%–73.1% compared with DD in all years studied. Total NO3−-N losses in this study were measured during the growing season (1 Apr. to 31 Oct.); the magnitude of NO3−-N losses and treatment effects may vary if studied year-round. Nitrous oxide fluxes were variable and low in magnitude throughout the study. Cumulated N2O losses were <1% of the applied N for all drainage types. Controlled drainage increased yields compared with SD and DD. The use of CD in the region could aid in reducing climate stresses, as well as overall NO3−-N loads exiting drainage systems and may enhance crop yields compared with conventional systems. Future studies on dissolved N2O losses from drainage water may provide important insight into whether dissolved N2O losses exceed surface emissions.
AFBV: A High-Performance Network Flow Classification Method for Multi-Dimensional Fields and FPGA Implementation
Authors: Zheng Ling , Qiu Zhiliang , Wang Weina , Pan Weitao , Sun Shiyong , Gao Ya
Published: January 2019

Network flow classification is a key function in high-speed switches and routers. It directly determines the performance of network devices. With the development of the Internet and various kinds of applications, the flow classification needs to support multi-dimensional fields, large rule sets, and sustain a high throughput. Software-based classification cannot meet the performance requirement as high as 100 Gbps. FPGA-based flow classification methods can achieve a very high throughput. However, the range matching is still challenging. For this, this paper proposes a range supported bit vector (RSBV) method. First, the characteristic of range matching is analyzed, then the rules are pre-encoded and stored in memory. Second, the fields of an input packet header are used as addresses to read the memory, and the result of range matching is derived through pipelined Boolean operations. On this basis, bit vector for any types of fields (AFBV) is further proposed, which supports the flow classification for multi-dimensional fields efficiently, including exact matching, longest prefix matching, range matching, and arbitrary wildcard matching. The proposed methods are implemented in FPGA platform. Through a two-dimensional pipeline architecture, the AFBV can operate at a high clock frequency and can achieve a processing speed of more than 100 Gbps. Simulation results show that for a rule set of 512-bit width and 1[Formula: see text]k rules, the AFBV can achieve a throughput of 520 million packets per second (MPPS). The performance is improved by 44% compared with FSBV and 30% compared with Stride BV. The power consumption is reduced by about 43% compared with TCAM solution.
长崎福建会馆与东亚商贸和文化网络建构
Authors: 廖 赤阳
Published: January 2019

长崎从400多年前就被编入华商所构筑的东亚贸易网络，并成为其中的一个重要战略据点，也由此成为日本华人社会的起点。而中日之间密切的文化网络也伴随着这一商贸网络而展开。本文旨在对17世纪至20世纪前期，以长崎福建会馆为中心的闽帮华商的跨国商贸与文化网络进行梳理，并通过此案对日华社会的历史特征，东亚历史的内发性与自律性、商贸网络与文化传播，同化、认同与融合，地域秩序、民族国家与跨国主义等具有普遍性的问题进行思考。
Subduction-related Manipur Ophiolite Complex, Indo-Myanmar Ranges: elemental and isotopic record of mantle metasomatism
Authors: Kingson Oinam , Bhutani Rajneesh , Balakrishnan S. , Dash J. K. , Shukla Anil D.
Published: January 2019

This study reports, for the first time, Sr and Nd isotope ratios from the mafic rocks in the Manipur Ophiolite Complex (MOC), along with new elemental abundances to show the subduction zone influence. The initial
87
Sr/
86
Sr ratios (for
t
= 127 Ma) range from 0.705230 to 0.709734. The initial
143
Nd/
144
Nd and
ɛ
Nd
t
(
t
= 127 Ma) range from 0.512611 to 0.512900 and +2.7 to +8.3, respectively. The high field strength element (HFSE) ratios vary widely, with Nb/Ta ranging from
c.
3 to 18 and Zr/Hf ranging from 20 to 41, indicating fluid–rock interaction in the presence of rutile. The correlated variation in the Nd and Sr isotope ratios and the HFSEs, including TiO
2
, reflects the variation in the slab-derived fluids. The light rare earth element (LREE) enriched and flat patterns yielded by the mafic rocks are modelled by varying the degree of melting of the fluid-metasomatized mantle. The subsequent influx of the slab-derived fluid at a greater depth caused the re-melting of the previously depleted wedge to produce the LREE-depleted patterns.

We propose that the geochemical variation recorded in the MOC rocks indicates the changing nature of fluid metasomatism of the mantle wedge across the subduction zone with time.
Connemara Marble, Co. Galway, Ireland: a Global Heritage Stone Resource proposal
Authors: Wyse Jackson Patrick N. , Caulfield Louise , Feely Martin , Joyce Ambrose , Parkes Matthew A.
Published: January 2019

Connemara Marble, a well-known distinctive decorative stone from the west of Ireland, is herein proposed as a Global Heritage Stone Resource. Connemara Marble is a sillimanite-grade ophicarbonate, dominated by dolomite and calcite with varying proportions of serpentine, diopside, forsterite, tremolite clinochlore and phlogopite. The marble displays intricate corrugated layers that range in colour from white through sepias to various shades of green. These features impart unique characteristics that set the marble apart from other ornamental stones. Characteristics reflect amphibolite-grade metamorphism of an impure siliceous dolomitic limestone during the Grampian orogeny (475–463 Ma). Olivine, diopside, tremolite along with calcite and dolomite were formed during the peak of metamorphism which was followed by a later pervasive hydrothermal metamorphism that led to the extensive growth of serpentine after olivine and diopside. It has been used since Neolithic times, but has been quarried and fashioned in Connemara since the eighteenth century, and widely utilized in buildings in Ireland and the UK, for cladding, banisters, columns and church fittings. Later in the late nineteenth and early twentieth centuries it was exported in large quantities to the USA for use in civic and educational buildings. Its many uses as an ornamental stone in the interiors of buildings and in Irish jewellery commands worldwide acclaim.
Scalable Analytics on Fast Data
Authors: Kipf Andreas , Pandey Varun , Böttcher Jan , Braun Lucas , Neumann Thomas , Kemper Alfons
Published: January 2019

Today’s streaming applications demand increasingly high event throughput rates and are often subject to strict latency constraints. To allow for more complex workloads, such as window-based aggregations, streaming systems need to support
stateful
event processing. This introduces new challenges for streaming engines as the state needs to be maintained in a consistent and durable manner and simultaneously accessed by complex queries for real-time analytics.

Modern streaming systems, such as Apache Flink, do not allow for efficiently exposing the state to analytical queries. Thus, data engineers are forced to keep the state in external data stores, which significantly increases the latencies until events become visible to analytical queries. Proprietary solutions have been created to meet data freshness constraints. These solutions are expensive, error-prone, and difficult to maintain. Main-memory database systems, such as HyPer, achieve extremely low query response times while maintaining high update rates, which makes them well-suited for analytical streaming workloads. In this article, we explore extensions to database systems to match the performance and usability of streaming systems.
Characterizing Directed and Undirected Networks via Multidimensional Walks with Jumps
Authors: Murai Fabricio , Ribeiro Bruno , Towlsey Don , Wang Pinghui
Published: January 2019

Estimating distributions of node characteristics (labels) such as number of connections or citizenship of users in a social network via edge and node sampling is a vital part of the study of complex networks. Due to its low cost, sampling via a random walk (RW) has been proposed as an attractive solution to this task. Most RW methods assume either that the network is undirected or that walkers can traverse edges regardless of their direction. Some RW methods have been designed for directed networks where edges coming into a node are not directly observable. In this work, we propose Directed Unbiased Frontier Sampling (DUFS), a sampling method based on a large number of coordinated walkers, each starting from a node chosen uniformly at random. It applies to directed networks with invisible incoming edges because it constructs, in real time, an undirected graph consistent with the walkers trajectories, and its use of random jumps to prevent walkers from being trapped. DUFS generalizes previous RW methods and is suited for undirected networks and to directed networks regardless of in-edge visibility. We also propose an improved estimator of node label distribution that combines information from initial walker locations with subsequent RW observations. We evaluate DUFS, compare it to other RW methods, investigate the impact of its parameters on estimation accuracy and provide practical guidelines for choosing them. In estimating out-degree distributions, DUFS yields significantly better estimates of the head of the distribution than other methods, while matching or exceeding estimation accuracy of the tail. Last, we show that DUFS outperforms uniform sampling when estimating distributions of node labels of the top 10% largest degree nodes, even when sampling a node uniformly has the same cost as RW steps.
Editorial
Authors: Andersen Rebekka , Evia Carlos
Published: January 2019

Technical communication (TC) practice is changing in significant ways, due largely to maturing technologies and increasing consumer demand for content designed for a multitude of devices and delivery channels. Whereas ten years ago technical communicators primarily produced static documents, today they primarily produce modular content components, the essential building blocks for the vast array of information products (e.g., user guides, training materials, product descriptions) that organizations must deliver in a variety of publishing formats, such as PDFs, websites, embedded user assistance, dynamic delivery, and mobile applications. In addition, technical communicators increasingly contribute to user experience (UX) projects, create video documentation, curate user-generated content, and manage social media communications.
Book review
Authors: Wisniewski Elaine
Published: January 2019

Bridgeford, T., & St.Amant, K. (Eds.), (2015).
Academy-industry Relationships and Partnerships: Perspectives for Technical Communicators.
Amityville, NY: Baywood Publishing Company.
Guest editor's introduction
Authors: Zdenek Sean
Published: January 2019

This special issue asks us to refl ect on the transformative potential of disability studies to reimagine technical and professional communication (TPC). Informing this special issue is the notion that disability "enables insight---critical, experiential, cognitive, sensory, and pedagogical insight" (Brueggemann, 2002, p. 795). Rather than consider questions of access from the margins---e.g. after we receive a letter of accommodation from a student, when we need to satisfy a legal mandate, or when we turn to our organization's web accessibility checklist---disability studies places disability and difference at the center of our practices and pedagogies (p. 814).
Designing for intersectional, interdependent accessibility
Authors: Gonzales Laura
Published: January 2019

Drawing on narratives (Jones, 2016; Jones & Walton, 2018) from bilingual technical communication projects, this article makes a case for the importance of considering language access and accessibility in crafting and sharing digital research. Connecting conversations in disability studies and language diversity, the author emphasizes how an interdependent (Price, 2011; Price & Kerchbaum, 2016), intersectional (Crenshaw, 1989; Medina & Haas, 2018) orientation to access through disability studies and translation can help technical communication researchers to design and disseminate digital research that is accessible to audiences from various linguistic backgrounds and who also identify with various dis/abilities.
Making Sense of the Design of International Institutions
Authors: Voeten Erik
Published: January 2019

The design of international institutions varies in many ways: Institutions can be more or less formal, flexible, independent, precise, inclusive, centralized, and so on. This article classifies theoretical efforts to make sense of these similarities and differences. First, some theories focus on the bargains or contracts that attempt to construct equilibrium behavior while other theories analyze institutional design as a dynamic process. Second, theories vary in whether they understand institutional design as a response to the environment in which institutions operate or as a function of the incentives, interests, values, initiatives, and power of the actors that created the institutions. The article discusses four ideal-typical theoretical approaches that fit in each quadrant of the resulting 2×2 typology: rational functionalist, distributive rationalist, historical institutionalist, and structural process theories. These approaches identify different causes for suboptimal or even dysfunctional institutional design: domestic politics, power politics, path dependence, and culture. The conclusion discusses how these theories can help us make sense of current challenges to institutions and their design.
Evaluation of Long-Term Wastewater Treatment Performances in Multi-Soil-Layering Systems in Small Rural Communities
Authors: Sato Kuniaki , Wakatsuki Toshiyuki , Iwashima Noriko , Masunaga Tsugiyuki
Published: January 2019

Multi-soil-layering (MSL) wastewater treatment systems consist of soil units (soil mixture blocks, SMB) arranged in a brick-like pattern surrounded by permeable layers of zeolite or alternating particles of homogeneous sizes that allow for a high hydraulic loading rate. This study evaluated the performances of MSL systems that have been operating for 17 to 20 years in small rural communities. Even though 20 years had passed since this system was installed, high organic matter treatment performance continued. Nitrogen removal was higher than with conventional soil systems. Two of the MSL systems continued to show high phosphorus removal performances, whereas in the third system, the adsorbing capacity was relatively low, requiring further investigation. Treatment performances were largely dependent upon the structure of the MSL systems. It appeared that improving the structure to enhance the contact efficiency between the wastewater and the soil in SMB was important for enhancing treatment performances. The combined use of existing wastewater treatment systems with the MSL system was effective for preventing environmental pollution over a long period.
Magnetodielectric Effects in Magnetorheological Elastomers Based on Polymer Fabric, Silicone Rubber, and Magnetorheological Suspension
Authors: Gavrilovici A. M. , Anitas E. M. , Chirigiu L. , Bica I. , Negrutiu M. L.
Published: January 2019

We fabricate a hybrid magnetorheological elastomer (hMRE) based on a microfiber cloth soaked with a mixture containing magnetorheological suspension (MRS) and silicone rubber (SR). Two parallel copper electrodes are attached to the hMRE and the capacitance C is measured as a function of time t, for fixed values of magnetic flux density B. We show that C is stable in time and is sensibly influenced by B, while the relative dielectric permittivity increases up to two orders of magnitude when B reaches 340 mT. We explain the physical mechanism which leads to the observed magnetodielectric effects. The obtained results can be used for various biomedical applications such as in fabrication of active biomagnetic membranes used in dental implantology.
Perfect Fluid Dark Matter Influence on Thermodynamics and Phase Transition for a Reissner-Nordstrom-Anti-de Sitter Black Hole
Authors: Xu Zhaoyi , Hou Xian , Wang Jiancheng , Liao Yi
Published: January 2019

Based on Reissner-Nordstrom-anti-de Sitter(RN-AdS) black hole surrounded by perfect fluid dark matter, we study the thermodynamics and phase transition by extending the phase space defined by the charge square Q2 and the conjugate quantity ψ, where ψ is a function of horizon radius. The first law of thermodynamics and the equation of state are derived in the form Q2=Q2(T,ψ). By investigating the critical behaviour of perfect fluid dark matter around Reissner-Nordstrom-anti-de Sitter black hole, we find that these thermodynamics system are similar to Van der Waals system and can be explained by mean field theory. We also explore the Ruppeiner thermodynamic geometry feature and their connection with microscopic structure. We find that in extended phase space there are existence singularity points of Ruppeiner curvature and they could explained as phase transitions.
Combination of MLFMA and ACA to Accelerate Computation of Scattering from Underground Targets
Authors: Liu Zhiwei , Tang Dan , Zhang Zhanyang , Zhang Yueyuan , Wang Xiaoli , Jie Shunli
Published: January 2019

Electromagnetic nondestructive evaluation of underground targets is of great significance for the safety of urban construction. Based on the accurate and efficient simulation of scattering, we can detect the underground targets successfully. As one of the most popular numerical methods in electromagnetics, surface integral equations solved by method of moments (MoM) are used to simulate the scattering from underground targets in this paper. The integral equation is discretized by RWG basis and Galerkin testing. Multilevel fast multipole algorithm (MLFMA) is used to decrease the computation complexity and memory cost. However, the octree used in MLFMA is not applied for rough surfaces and targets together; both the surface and target need to construct octree separately. Since the combination of MLFMA and ACA can build a more efficient method to compute scattering from underground targets, adaptive cross approximation (ACA) is used to compress the impedance matrix instead of MLFMA for the coupling action between the rough surface and target. That is to say that, when calculating the scattering of two targets, target self-interaction is suitable for MLFMA calculation and the coupling between targets is approximated by ACA. Numerical results demonstrate the accuracy and efficiency of our proposed method.
IntraduralStaphylococcus aureusAbscess of theCauda Equinain an Otherwise Healthy Patient
Authors: Sorenson Thomas J. , Lanzino Giuseppe
Published: January 2019

Abscesses involving the spine are usually located in the epidural space. In rare circumstances, intradural spinal abscesses can occur, typically in the setting of tuberculosis or other predisposing systemic conditions. In this illustrated case report, we discuss the imaging and intraoperative findings of an otherwise healthy patient with an intradural abscess of thecauda equinacaused byStaphylococcus aureus. Although rare, intradural spinal abscesses can occur in the absence of typical “red flags” for infection, and a bacterial abscess should be considered in the differential diagnosis of intradural spinal cystic enhancing lesions.
An Airfield Soil Pavement Design Method Based on Rut Depth and Cumulative Fatigue
Authors: Zhang Duoyao , Cai Liangcai , Zhou Shaohui
Published: January 2019

The structure and damage modes of soil pavement, as well as existing problems in current design methods, were comprehensively analyzed, and a new design method for airfield soil pavement was proposed. The proposed method avoids the use of the “designed aircraft” concept and instead adopts the cumulative fatigue theory widely used in permanent airfield design at present. Moreover, in view of the lack of aircraft wheel trajectory distribution data, an approximate method for calculating the wheel trajectory distribution considering the side slip distance of the aircraft was proposed and the equivalent width of the wheel tread was calculated by introducing the modulus ratio. Finally, the pass-to-coverage ratio was obtained. According to the characteristics and damage modes of airfield soil pavement, rut depth was determined to be the unique factor affecting soil pavement damage, and resilient modulus was used as the control variable to improve the adverse impact of the empirical method. Furthermore, according to the rut prediction formula for airfield soil pavement put forward by the US Army Engineer Research and Development Center, a fatigue equation based on the resilient modulus was proposed to calculate the allowable number of repetitions. To verify the reliability of the design method, a test section was constructed at a test center in Jining, China, and the theoretical maximum allowable repetitions on the soil runway were calculated by the currently used California bearing ratio test, the β-fatigue equation, and the proposed method. Aircraft traffic tests were carried out on the test section. Finally, the theoretical and test results were compared and the values calculated via the proposed method were found to be consistent with experimental values, thereby validating the reliability of the method.
Initial Parameter Analysis about Resonant Orbits in Earth-Moon System
Authors: Liu Li-Bo , Qian Ying-Jing , Yang Xiao-Dong
Published: January 2019

The initial parameters about resonant orbits in the Earth-Moon system were investigated in this study. Resonant orbits with different ratios are obtained in the two-body problem and planar circular restricted three-body problem (i.e., PCRTBP). It is found that the eccentricity and initial phase are two important initial parameters of resonant orbits that affect the closest distance between the spacecraft and the Moon. Potential resonant transition or resonant flyby may occur depending on the possibility of the spacecraft approaching the Moon. Based on an analysis of ballistic capture and flyby, the Kepler energy and the planet’s perturbed gravitational sphere are used as criteria to establish connections between the initial parameters and the possible “steady” resonant orbits. The initial parameter intervals that can cause instability of the resonant orbits in the CRTBP are obtained. Examples of resonant orbits in 1:2 and 2:1 resonances are provided to verify the proposed criteria.
π-N Drell-Yan Process in TMD Factorization
Authors: Wang Xiaoyu , Lu Zhun
Published: January 2019

This article presents the review of the current understanding on the pion-nucleon Drell-Yan process from the point of view of the TMD factorization. Using the evolution formalism for the unpolarized and polarized TMD distributions developed recently, we provide the theoretical expression of the relevant physical observables, namely, the unpolarized cross section, the Sivers asymmetry, and the cos⁡2ϕ asymmetry contributed by the double Boer-Mulders effects. The corresponding phenomenology, particularly at the kinematical configuration of the COMPASS πN Drell-Yan facility, is displayed numerically.
Synthesis of 1,2,3-Triazole Derivatives and Its Evaluation as Corrosion Inhibitors for Carbon Steel
Authors: Resende Gabriel O. , Teixeira Sara F. , Figueiredo Igor F. , Godoy Alexandre A. , Lougon Dafne Júlia F. , Cotrim Bruno A. , Souza Flávia C. de
Published: January 2019

Heterocyclic compounds containing the 1,2,3-triazole moiety can be synthesized through click-chemistry, which is rapid reactions with good yields allowing the synthesis of great derivatives diversity by making minor changes in the reagents. The products were obtained with good yields through a synthetic route which uses ready available nonexpensive commercial reagents and without any further purification of any product or intermediate. The carbon steel anticorrosive activity was tested through weight loss and electrochemical assays in acid media. It was observed relevant inhibition efficiency (> 90%) for inhibitors1and2. From Langmuir isotherm, it was hypothesized the adsorption of inhibitors on the carbon steel surface might occur by physical and chemical interaction; however, the activation energy raised suggests a physisorption process for the interaction of the inhibitor on the carbon steel surface.
Accidental Intralenticular Injection of Ozurdex® for Branch Retinal Vein Occlusion: Intact Posterior Capsule and Resolution of Macular Edema
Authors: Kurt Ali , Durukan Ali Hakan , Küçükevcilioğlu Murat
Published: January 2019

Purpose. We present a case of accidental intralenticular injection of Ozurdex implant in a patient with macular edema secondary to branch retinal vein occlusion. Method. A case report. Results. Intravitreal dexamethasone implant injection had been performed for macular edema due to left superior temporal vein branch occlusion to the left eye of a 78-year-old male patient. The slit-lamp examination 85 days later revealed that the dexamethasone implant was intralenticular. The best-corrected visual acuity (BCVA) was 0.16 on the Snellen chart. Cataract surgery was decided on for the cataract as there was no anterior chamber inflammation, the intraocular pressure (IOP) was normal, and the macular edema had resolved. Uneventful phacoemulsification within the bag intraocular lens placement was performed. Conclusions. Accidental intralenticular Ozurdex injection is an extremely rare complication. The surgeon must decide whether to continue to observe or intervene immediately when such a complication is encountered. Cataract surgery can be planned if the macular edema has resolved and a cataract has developed. It is important to evaluate the posterior capsule with ultrasound biomicroscopy and Scheimpflug imaging before the cataract surgery to ensure a safe surgical procedure.
Simultaneous Determination of Six Active Components in Danggui Kushen Pills via Quantitative Analysis of Multicomponents by Single Marker
Authors: Bao Huiwei , Chi Jihong , Yang Huailei , Liu Fangxin , Fang Kuo , Xu Yang
Published: January 2019

In this paper, a valid evaluation method for the quality control of Danggui Kushen pills (DKP) has been established based on quantitative analysis of multicomponents by single marker (QAMS). Gallic acid, matrine, oxymatrine, catechin, ferulic acid, and rutin were selected as the indexes for quality evaluation of DKP. The analysis was achieved on an Agilent ZORBAX SB-C18 column (250  mm × 4.6  mm, 5 μm) via gradient elution. Gallic acid was used as internal standard to determine the relative correction factors (RCF) between gallic acid and other five constituents in DKP. The contents of those components were calculated at the same time. The accuracy of QAMS method was verified by comparing the contents of six components calculated by external standard (ES) method with those of the QAMS method. It turned out that there was no significant difference between the quantitative results of QAMS method and external standard method. The proposed QAMS method was proved to be accurate and feasible according to methodological experiments, which provided an accurate, efficient, and economical approach for quality evaluation of DKP.
Dynamical Analysis of Approximate Solutions of HIV‐1 Model with an Arbitrary Order
Authors: Asma  , Ali Nigar , Zaman Gul , Zeb Anwar , Erturk Vedat Suat , Jung Il Hyo
Published: January 2019

This article studies the dynamical behavior of the analytical solutions of the system of fraction order model of HIV‐1 infection. For this purpose, first, the proposed integer order model is converted into fractional order model. Then, Laplace‐Adomian decomposition method (L‐ADM) is applied to solve this fractional order HIV model. Moreover, the convergence of this method is also discussed. It can be observed from the numerical solution that (L‐ADM) is very simple and accurate to solve fraction order HIV model.
Metastatic Tumor-in-a-Dish, a Novel Multicellular Organoid to Study Lung Colonization and Predict Therapeutic Response
Authors: Ramamoorthy Prabhu , Thomas Sufi Mary , Kaushik Gaurav , Subramaniam Dharmalingam , Chastain Katherine M. , Dhar Animesh , Tawfik Ossama , Kasi Anup , Sun Weijing , Ramalingam Satish , Gunewardena Sumedha , Umar Shahid , Mammen Joshua M. , Padhye Subhash B. , Weir Scott J. , Jensen Roy A. , Sittampalam G. Sitta , Anant Shrikant
Published: January 2019

Metastasis is a major cause of cancer-related deaths. A dearth of preclinical models that recapitulate the metastatic microenvironment has impeded the development of therapeutic agents that are effective against metastatic disease. Because the majority of solid tumors metastasize to the lung, we developed a multicellular lung organoid that mimics the lung microenvironment with air sac–like structures and production of lung surfactant protein. We used these cultures, called primitive lung-in-a-dish (PLiD), to recreate metastatic disease using primary and established cancer cells. The metastatic tumor-in-a-dish (mTiD) cultures resemble the architecture of metastatic tumors in the lung, including angiogenesis. Pretreating PLiD with tumor exosomes enhanced cancer cell colonization. We next tested the response of primary and established cancer cells to current chemotherapeutic agents and an anti-VEGF antibody in mTiD against cancer cells in two-dimensional (2D) or 3D cultures. The response of primary patient-derived colon and ovarian tumor cells to therapy in mTiD cultures matched the response of the patient in the clinic, but not in 2D or single-cell–type 3D cultures. The sensitive mTiD cultures also produced significantly lower circulating markers for cancer similar to that seen in patients who responded to therapy. Thus, we have developed a novel method for lung colonization in vitro, a final stage in tumor metastasis. Moreover, the technique has significant utility in precision/personalized medicine, wherein this phenotypic screen can be coupled with current DNA pharmacogenetics to identify the ideal therapeutic agent, thereby increasing the probability of response to treatment while reducing unnecessary side effects.

Significance:

A lung organoid that exhibits characteristics of a normal human lung is developed to study the biology of metastatic disease and therapeutic intervention.
Outcomes of Moderate-to-Severe Acute Kidney Injury following Left Ventricular Assist Device Implantation
Authors: Harmon David M. , Tecson Kristen M. , Lima Brian , Collier Justin D.G. , Shaikh Asad F. , Still Sasha , Baxter Ronald D. , Lew Nicole , Thakur Richa , Felius Joost , Hall Shelley A. , Gonzalez-Stawinski Gonzalo V. , Joseph Susan M.
Published: January 2019

Background: Although acute kidney injury (AKI) is a common complication following cardiac surgery, less is known about the occurrence and consequences of moderate/severe AKI following left ventricular assist device (LVAD) implantation. Methods: All patients who had an LVAD implanted at our center from 2008 to 2016 were reviewed to determine the incidence of, and risk factors for, moderate/severe (stage 2/3) AKI and to compare postoperative complications and mortality rates between those with and those without moderate/severe AKI. Results: Of 246 patients, 68 (28%) developed moderate/severe AKI. A multivariable logistic regression comprising body mass index and prior sternotomy had fair predictive ability (area under the curve = 0.71). A 1-unit increase in body mass index increased the risk of moderate/severe AKI by 7% (odds ratio = 1.07; 95% confidence interval: 1.03–1.11); a prior sternotomy increased the risk more than 3-fold (odds ratio = 3.4; 95% confidence interval: 1.84–6.43). The group of patients with moderate/severe AKI had higher rates of respiratory failure and death than the group of patients with mild/no AKI. Patients with moderate/severe AKI were at 3.2 (95% confidence interval: 1.2–8.2) times the risk of 30-day mortality compared to those without. Even after adjusting for age and Interagency Registry for Mechanically Assisted Circulatory Support profile, those with moderate/severe AKI had 1.75 (95% confidence interval: 1.03–3.0) times the risk of 1-year mortality compared to those without. Discussion: Risk-stratifying patients prior to LVAD placement in regard to AKI development may be a step toward improving surgical outcomes.
Cervical Spine Osteoblastoma with an Aneurysmal Bone Cyst in a 2-Year-Old Child: A Case Report
Authors: Mishra Ajit , Pruthi Nupur , Nandeesh B.N. , Shukla Dhaval
Published: January 2019

Osteoblastomas and aneurysmal bone cysts are uncommon benign tumors of the spine. Their presentation can vary between diffuse pain, restriction of neck movements, torticollis, radiculopathy, and myelopathy. Complete excision is the best treatment to achieve a cure, but recurrence is not uncommon. A combination of the two conditions in the pediatric population is extremely rare. To the best of the authors’ knowledge, only 2 cases of such a combination in the cervical spine have been reported in the literature. We report the case of a 2-year-old child having a right C4 lateral mass osteoblastoma with an aneurysmal bone cyst. The child underwent complete surgical excision of the lesion with fusion.
The Role of MRI Biomarkers and Their Interactions with Cognitive Status and APOE ε4 in Nondemented Elderly Subjects
Authors: Liang Xue , Yin Zhenyu , Liu Renyuan , Zhao Hui , Wu Sichu , Lu Jiaming , Qing Zhao , Wei Yongyue , Yang Qingxian , Zhu Bin , Xu Yun , Zhang Bing
Published: January 2019

Purpose: (1) To investigate atrophy patterns of hippocampal subfield volume and Alzheimer’s disease (AD)-signature cortical thickness in mild cognitive impairment (MCI) patients; (2) to explore the association between the neuropsychological (NP) and the brain structure in the MCI and older normal cognition group; (3) to determine whether these associations were modified by the apolipoprotein E (APOE) ε4 gene and cognitive status. Methods: The FreeSurfer software was used for automated segmentation of hippocampal subfields and AD-signature cortical thickness for 22 MCI patients and 23 cognitive normal controls (NC). The volume, cortical thickness, and the neuropsychological scale were compared with two-sample t tests. Linear regression models were used to determine the association between the NP and the brain structure. Results: Compared with the NC group, MCI patients showed a decreased volume of the left presubiculum, subiculum and right CA2_3 and CA4_DG (p < 0.05, FDR corrected). The volume of these regions was positively correlated with NP scores. Of note, these associations depended on the cognitive status but not on the APOE ε4 status. The left subiculum and presubiculum volume were positively correlated with the Montreal Cognitive Assessment (MoCA) scores only in the MCI patients. Conclusion: Atrophy of the hippocampal subfields may be a powerful biomarker for MCI in the Chinese population.
Blockade of Serotonin 2C Receptors with SB-242084 Moderates Reduced Locomotor Activity and Rearing by Cannabinoid 1 Receptor Antagonist AM-251
Authors: Bogáthy Emese , Kostyalik Diana , Petschner Peter , Vas Szilvia , Bagdy Gyorgy
Published: January 2019

The endocannabinoid and serotonin (5-HT) systems have key roles in the regulation of several physiological functions such as motor activity and food intake but also in the development of psychiatric disorders. Here we tested the hypothesis, whether blockade of serotonin 2C (5-HT2C) receptors prevents the reduced locomotor activity and other behavioral effects caused by a cannabinoid 1 (CB1) receptor antagonist. As a pretreatment, we administered SB-242084 (1 mg/kg, ip.), a 5-HT2C receptor antagonist or vehicle (VEH) followed by the treatment with AM-251 (5 or 10 mg/kg, ip.), a CB1 receptor antagonist or VEH. The effects of the two drugs alone or in co-administration were investigated in social interaction (SI) and elevated plus maze (EPM) tests in male Wistar rats. Our results show that AM-251 decreased the time spent with rearing in the SI test and decreased locomotor activity in EPM test. In contrast, SB-242084 produced increased locomotor activity in SI test and evoked anxiolytic-like effect in both SI and EPM tests. When applied the drugs in combination, these behavioral effects of AM-251 were moderated by SB-242084. Based on these findings, we conclude that certain unwanted behavioral effects of CB1 receptor antagonists could be prevented by pretreatment with 5-HT2C receptor antagonists.
Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles
Authors: Prevot Thomas D. , Li Guanguan , Vidojevic Aleksandra , Misquitta Keith A. , Fee Corey , Santrac Anja , Knutson Daniel E. , Stephen Michael Rajesh , Kodali Revathi , Zahn Nicolas M. , Arnold Leggy A. , Scholze Petra , Fisher Janet L. , Marković Bojan D. , Banasr Mounira , Cook James M. , Savic Miroslav , Sibille Etienne
Published: January 2019

Altered gamma-aminobutyric acid (GABA) function is consistently reported in psychiatric disorders, normal aging, and neurodegenerative disorders and reduced function of GABA interneurons is associated with both mood and cognitive symptoms. Benzodiazepines (BZ) have broad anxiolytic, but also sedative, anticonvulsant and amnesic effects, due to nonspecific GABA-A receptor (GABAA-R) targeting. Varying the profile of activity of BZs at GABAA-Rs is predicted to uncover additional therapeutic potential. We synthesized four novel imidazobenzodiazepine (IBZD) amide ligands and tested them for positive allosteric modulation at multiple α-GABAA-R (α-positive allosteric modulators), pharmacokinetic properties, as well as anxiolytic and antidepressant activities in adult mice. Efficacy at reversing stress-induced or age-related working memory deficits was assessed using a spontaneous alternation task. Diazepam (DZP) was used as a control. Three ligands (GL-II-73, GL-II-74, and GL-II-75) demonstrated adequate brain penetration and showed predictive anxiolytic and antidepressant efficacies. GL-II-73 and GL-II-75 significantly reversed stress-induced and age-related working memory deficits. In contrast, DZP displayed anxiolytic but no antidepressant effects or effects on working memory. We demonstrate distinct profiles of anxiolytic, antidepressant, and/or pro-cognitive activities of newly designed IBZD amide ligands, suggesting novel therapeutic potential for IBZD derivatives in depression and aging.
Nutrition During Pregnancy, Lactation and Early Childhood and its Implications for Maternal and Long-Term Child Health: The Early Nutrition Project Recommendations
Authors: Koletzko Berthold , Godfrey K.M. , Poston Lucilla , Szajewska Hania , van Goudoever Johannes B. , de Waard Marita , Brands Brigitte , Grivell Rosalie M. , Deussen Andrea R. , Dodd Jodie M. , Patro-Golab Bernadeta , Zalewski Bartlomiej M. ,   EarlyNutrition Project Systematic Review Group
Published: January 2019

Background: A considerable body of evidence accumulated especially during the last decade, demonstrating that early nutrition and lifestyle have long-term effects on later health and disease (“developmental or metabolic programming”). Methods: Researchers involved in the European Union funded international EarlyNutrition research project consolidated the scientific evidence base and existing recommendations to formulate consensus recommendations on nutrition and lifestyle before and during pregnancy, during infancy and early childhood that take long-term health impact into account. Systematic reviews were performed on published dietary guidelines, standards and recommendations, with special attention to long-term health consequences. In addition, systematic reviews of published systematic reviews on nutritional interventions or exposures in pregnancy and in infants and young children aged up to 3 years that describe effects on subsequent overweight, obesity and body composition were performed. Experts developed consensus recommendations incorporating the wide-ranging expertise from additional 33 stakeholders. Findings: Most current recommendations for pregnant women, particularly obese women, and for young children do not take long-term health consequences of early nutrition into account, although the available evidence for relevant consequences of lifestyle, diet and growth patterns in early life on later health and disease risk is strong. Interpretation: We present updated recommendations for optimized nutrition before and during pregnancy, during lactation, infancy and toddlerhood, with special reference to later health outcomes. These recommendations are developed for affluent populations, such as women and children in Europe, and should contribute to the primary prevention of obesity and associated non-communicable diseases.