bluuebunny/crossref_metadata_2025 huggingface dataset:
Desain dan Analisis Perubahan Fluks Magnet Terhadap Efek Peredaman Pada Prototipe Suspensi Pintar
Authors: Wahjudi Sadar
Published: November 2020

The vehicle is one of basic needs for supporting mobility of people. Comfort and safety are demanded in every vehicle, especially in its suspension system. The existing suspension systems can’t maximize comfort and safety because it is still hydraulic and pneumatic based, without magnetic system. The purposes of the analysis is building magnetic suspension system with variations at the amount of coil and analyzing absorbing time. The methods of the analysis are determining concept, making the designs, determining components specification, making device block diagram, making wiring diagrams, making the device, taking the absorbing time datas, and the analyzing the data. The results of the analysis are the amount of coil is straight compared to the magnetic force and absorbing time. The most significant solenoid is the one which has 900 coils and has absorbing time at 9.6 seconds.
Analisa Teknoekonomi Biogas Dari Eceng Gondok dengan Stater Kotoran Sapi
Authors: Mulyati Meylinda
Published: November 2020

Water hyacinth is a waste that can be utilized by the community as an alternative potential for biogas energy. The formation of biogas from water hyacinth requires a residence time (LT) that is still long, which is between 30-35 days for the formation of methane. So that the process of forming methane is not too long, a stater is needed so that methanogenic bacteria can increase from cow dung so that the residence time is much shorter. The process of making biogas starts from making a digester, the process of taking water hyacinth by chopping water hyacinth, preparing cattle dung stater. The purpose of this study is to analyze technically and economically biogas from water hyacinth with cow manure stater. This research was carried out through several stages, namely: preparation of raw materials, stater and plastic biogas digester and techno-economic analysis. In this study the ratio of raw material 1: 1 (water hyacinth chopped 20 kg, water 20 kg) and the addition of stater cattle dung 6 kg.

The results of this study are that the technical aspects of biogas start production after 10 days of filling the digester at pH 7.1. Biogas produced is known by direct flame test. Visible on the 10th day the resulting flame is still small, but this shows that the gas has been formed. The pH of the digester is between 4.7 and 8.5. The decrease in TS value from the inlet which is 46 kg to the outlet is 28 kg, indicating that there has been degradation in the substrate in the digester. On the economical aspect the investment cost of a biogas installation in a synthetic digester is IDR 1,500,000.00. Variable costs are the cost of water hyacinth, cow dung and water of Rp 150,000.00 per year. The Cost of Biogas Production is Rp 3,836.08 and if it is sold at a margin of 50% the selling price is Rp 5,800. The break even point in kilograms is 267.2 and in rupiahs is Rp 1.025,000.00. This payback period for investment in biogas business is 2.86 years.
Pengaruh Waktu dan Temperatur terhadap Sifat Mekanik Pasir dan Kualitas Produk Cor dengan Metode Shell Moulding
Authors: Kusnowo Roni , Gunara Sophiadi , Fauzan Syani Ghozali
Published: November 2020

The shell molding method is one of the processes of coating sand grains in a thermo setting resin which preserves heat on the model. To produce castings products that have good quality and produce maximum mechanical properties from the shell molding process, it must be known that the right procedure stages such as the right heating time. But currently there is no technical procedure that is found that is the right temperature and heating time for making shell molding to produce good surface quality of castings. This study aims to determine the effect of temperatures and heating time on the mechanical properties of RCS (resin coated sand) and the quality of the object castings. A series of testing methods, carried out by heating the RCS on the sample mold bending and hardness test. Testing the mechanical properties of sand includes bending test and hardness test. The time variations used in sand heating are 1 minute, 2 minutes and 3 minutes with temperature variations of 1800C, 2000C, 2200C, 2400C, 2600C and 2800C. After knowing the results of the most optimal temperature and time from testing mechanical properties then making molds using the shell molding method, the molding material used is aluminum. The mold formed from the shell molding method is then cast using NiHard1 material with a temperature of 14000C. The results of the castings will be identified visually and compared with the mechanical properties of the sand obtained. The results of this study obtained the highest value on the graph of the results of mechanical properties testing at a temperature of 2200C with a heating time of 2 minutes. The results of castings best viewed in terms of visual obtained by heating time for 2 minutes and 3 minutes at a temperature of 2200C. This showed that the heating time for 2 minutes and 3 minutes at the temperature of 2200C results in the highest mechanical properties and the best quality of castings for shell molding method.
Analisa Laju Pelepasan Kalor Kondensor 10 U dan Separation Condenser Dengan Penambahan Subcooler Terhadap Koefisien Prestasi Mesin Pendingin Refrigerator Menggunakan Refrigerant Liquefied Petroleum Gas
Authors: Yahya Amirul , Kristianta Franciscus Xaverius , Ilminnafik Nasrul
Published: November 2020

The research used an experimental method by comparing the use of condenser separation with addition subcooler and condenser 10 U. In the same process condensation was done with the same condenser length with varying refrigerant discharge of 114x10-6 m3/s, 131x10-6 m3/s and 148x10-6 m3/s. The study used a refrigerant LPG (Liquefied Petroleum Gas) with a composition of 50% butane and propane 50%. The objective of study was to analyze heat release rate values ​​of both condensers on the coefficient of machine / COP (Coefficient of Performance) value of the refrigerator. Research on the 114x10-6 m3/s refrigerant discharge resulted in average of heat release rate separation condenser with addition subcooler higher than 10 U condenser with value of 0.000455727 kW. Refrigerant discharge test 131x10-6 m3/s, the average of heat release rate separation condenser with addition subcooler is higher than the condenser 10 U of 0.000297211 kW. Refrigerant discharge test 148x10-6 m3/s, condenser 10 U yields average of heat release rate value higher than separation condenser with addition subcooler amount of 0,014013777 kW. The average value of heat release rate by the condenser 10 U will have the same trend value of COP, while at the separation condenser with addition subcooler yielding a value which is inversely proportional to the COP yield, the lower of heat release rate the resulting COP value will increase.
CHARACTER BUILDING OF ALTRUISM IN ENGLISH TEXTBOOK OF SENIOR HIGH SCHOOL
Authors: Nainggolan Elsa ernawati , Simamora Juliatri Goretti
Published: November 2020

This study aimed at analyzing altruism character in the three English textbooks of senior high school grade X, XI, and XII. Using content analysis, words, phrases, and clauses presenting altruism in the reading text, dialogue, and tasks were examined. The study revealed that in the English textbook of grade X, the altruism aspect indicating ‘pro-social behavior’ and ‘environmental care’ could be frequently found in reading text, dialogue, and task. However, other altruism aspects such ‘giving empathy’ missed in the reading text and ‘reducing inequality’ does not appear in the reading text and dialogue. Meanwhile in the grade XI, ‘giving empathy’ and ‘pro-social behavior’ occur in dialogue and task yet cannot be identified in the reading text. Moreover, ‘environmental care’ only shows up in dialogue and task, while ‘reducing inequality’ is nowhere to be found. In the grade XII, ‘giving empathy’, ‘pro-social behavior’ and ‘environmental care’ could be identified in the reading text, dialogue, and task. Unfortunately, ‘reducing inequality’ aspects only occur in the task. The inconsistent altruism character maintained in the English textbooks used in grade X, XI, and XII of senior high school displayed the missing opportunity to shape students’ altruistic behavior. Considering that senior high school is the stage where students start developing the ability to think logically about abstract ideas, altruism character should be inculcated in the development of English learning material in relevance to students’ intellectual and emotional level.
AREAS OF MISSPELLING PHONEME IN SANDIAGA UNO’S SPEECH: A PHONOLOGICAL APPROACH
Authors: Ikhsan Riel Akmal , Ambalegin Ambalegin
Published: November 2020

This study is chosen to be the main subject in the term of linguistic study due to the popular issue in linguistic area, that is phonology, one of the focused subjects in linguistic aspect in English. Phonology also has several impacts to the people who involve in the language and linguistic subject and matter. Based from the related research, it is about the misspelling phoneme areas in the speech made by a public figure in Indonesia, who is Sandiaga Uno. The main purpose for this research is to find out the areas of misspelling phoneme made by Sandiaga Uno in his speech as the governor candidate for Jakarta, candidate for vice president and also as the public figure in Indonesia. The main result is the phenomenon of misspelling phoneme was existent in the area of dental like the phoneme /ɵ/, area of glottal stop such the sound /ᴅ/, and also the area of stop such the phoneme /ʃ/. This present research will use the phonological approach in linguistic study. Moreover, this present research will use the descriptive qualitative method in analysing and presenting the result of the research. This present research will analyse about the misspelling phoneme areas in phonology study. The data source will be taken from the speech by Sandiaga Uno. The approach that will be used for this present research will be the phonological approach in Linguistics.
MEETING ROOMS NAMING IN EAST JAVA GOVERNMENTAL BUILDING: A STUDY OF ANTHROPOLOGICAL LINGUSITICS
Authors: Permataswari Elvana
Published: November 2020

Naming is a specific linguistic act, intimately linked with values, traditions, hopes, fears and events in people’s lives. Names reveal the many preferences of their owners (or givers) in terms of real life objects, actions, features and beliefs. Place names provide the most useful geographical reference system in the world. The topic of names is a multidisciplinary field that has occupied the attention of philosophers of language, anthropologists, linguists and ordinary people. In this study, I try to analyze the names of meeting rooms in the East Java Governmental Building. The reason to choose this object is because the East Java Governmental Building is the center of government/ administration in East Java. This study aims to find out the kinds of names applied in the naming of meeting rooms in the East Java Governmental Building and the presuppose reasons behind the name chosen of the East Java Governmental Building. This study is a qualitative study. Based on the classification of the data, they were classified to two groups: the names of governors in East Java and the names of the kings or military chief of great kingdoms in East Java. The meeting rooms in the governmental building of East Java are named after important people in the history of the province. To conclude, the administration named all the meeting rooms, as the most important rooms in the building to welcome guests, using the name of people who have big influence and involvement in the history of East Java so that it has roots to its history.
MAIN CHARACTER’S PERSONALITY ON “A CARIBBEAN MYSTERY” BY AGATHA CHRISTIE
Authors: Khotimah Husnul , Yulianto Bambang , Laili Elisa Nurul
Published: November 2020

Tujuan dari penelitian ini adalah: 1. Mendeskripsikan tipe psikologis tokoh utama dalam “A Caribbean Mystery” karya Agatha Christie berdasarkan teori psikoanalisis Carl Gustav Jung. 2. Mendeskripsikan faktor-faktor apa saja yang mempengaruhi psikologis tokoh utama dalam “A Caribbean Mystery” karya Agatha Christie berdasarkan teori psikoanalisis Sigmund Freud. Metode penelitian yang digunakan dalam penelitian ini adalah pendekatan kualitatif. Sumber data penelitian adalah novel yang berjudul "A Caribbean Mystery"  dan data penelitian tersebut meliputi: Jenis dan Faktor Psikologi yang mempengaruhi psikologi tokoh utama. Teknik pengumpulan data menggunakan teknik pustaka yaitu dokumen. Teknik analisis data menggunakan teknik membaca, menandai, coding dan menganalisis. Hasil penelitian dapat dirumuskan bahwa terdapat dua bentuk psikologi pada manusia, yaitu jenis psikologi yang ada dalam alam sadar dan tidak sadar. Faktor yang mempengaruhi psikologi manusia terdiri dari faktor personal dan faktor situasional, namun dalam novel “A Caribbean Mystery” faktor yang mempengaruhi psikologi tokoh utama didominasi oleh faktor personal.
FIGURES OF SPEECH REFLECTING LOATHING
Authors: Ambalegin Ambalegin , Arianto Tomi
Published: November 2020

This descriptive qualitative research identified briefly the figurative expressions on Donald Trump’s tweeter post. It used Abrams and Harpham’s theory. This research applied observational method and non-participation technique in collecting the data. Then, this research applied semantic identity method and semantic-competence in equalizing to analyze the data. The figure of similarity found mostly in the comments or responses. There were expressions of simile, metaphor, allusion, and personification. The comments or responses mostly compared the one to the other living or non-living things to express how loathe the writers of comments. The figures of speech criticized the one’s works and acts. On the other hand, the expressions attacked the face (FTA). Previously, the figures of speech were used in the literary works to show the expression aesthetically. But now, the freedom to express the ideas makes the figures of speech not only to show the ‘sweet and smooth’ language but also ‘rude’ language.
The Role of Host-Generated H2S in Microbial Pathogenesis: New Perspectives on Tuberculosis
Authors: Rahman Md. Aejazur , Glasgow Joel N. , Nadeem Sajid , Reddy Vineel P. , Sevalkar Ritesh R. , Lancaster Jack R. , Steyn Adrie J. C.
Published: November 2020

For centuries, hydrogen sulfide (H2S) was considered primarily as a poisonous gas and environmental hazard. However, with the discovery of prokaryotic and eukaryotic enzymes for H2S production, breakdown, and utilization, H2S has emerged as an important signaling molecule in a wide range of physiological and pathological processes. Hence, H2S is considered a gasotransmitter along with nitric oxide (•NO) and carbon monoxide (CO). Surprisingly, despite having overlapping functions with •NO and CO, the role of host H2S in microbial pathogenesis is understudied and represents a gap in our knowledge. Given the numerous reports that followed the discovery of •NO and CO and their respective roles in microbial pathogenesis, we anticipate a rapid increase in studies that further define the importance of H2S in microbial pathogenesis, which may lead to new virulence paradigms. Therefore, this review provides an overview of sulfide chemistry, enzymatic production of H2S, and the importance of H2S in metabolism and immunity in response to microbial pathogens. We then describe our current understanding of the role of host-derived H2S in tuberculosis (TB) disease, including its influences on host immunity and bioenergetics, and onMycobacterium tuberculosis(Mtb)growth and survival. Finally, this review discusses the utility of H2S-donor compounds, inhibitors of H2S-producing enzymes, and their potential clinical significance.
A Novel Text-Mining Approach for Retrieving Pharmacogenomics Associations From the Literature
Authors: Pandi Maria-Theodora , van der Spek Peter J. , Koromina Maria , Patrinos George P.
Published: November 2020

Text mining in biomedical literature is an emerging field which has already been shown to have a variety of implementations in many research areas, including genetics, personalized medicine, and pharmacogenomics. In this study, we describe a novel text-mining approach for the extraction of pharmacogenomics associations. The code that was used toward this end was implemented using R programming language, either through custom scripts, where needed, or through utilizing functions from existing libraries. Articles (abstracts or full texts) that correspond to a specified query were extracted from PubMed, while concept annotations were derived by PubTator Central. Terms that denote a Mutation or a Gene as well as Chemical compound terms corresponding to drug compounds were normalized and the sentences containing the aforementioned terms were filtered and preprocessed to create appropriate training sets. Finally, after training and adequate hyperparameter tuning, four text classifiers were created and evaluated (FastText, Linear kernel SVMs, XGBoost, Lasso, and Elastic-Net Regularized Generalized Linear Models) with regard to their performance in identifying pharmacogenomics associations. Although further improvements are essential toward proper implementation of this text-mining approach in the clinical practice, our study stands as a comprehensive, simplified, and up-to-date approach for the identification and assessment of research articles enriched in clinically relevant pharmacogenomics relationships. Furthermore, this work highlights a series of challenges concerning the effective application of text mining in biomedical literature, whose resolution could substantially contribute to the further development of this field.
A Boundary Distance-Based Symbolic Aggregate Approximation Method for Time Series Data
Authors: He Zhenwen , Long Shirong , Ma Xiaogang , Zhao Hong
Published: November 2020

A large amount of time series data is being generated every day in a wide range of sensor application domains. The symbolic aggregate approximation (SAX) is a well-known time series representation method, which has a lower bound to Euclidean distance and may discretize continuous time series. SAX has been widely used for applications in various domains, such as mobile data management, financial investment, and shape discovery. However, the SAX representation has a limitation: Symbols are mapped from the average values of segments, but SAX does not consider the boundary distance in the segments. Different segments with similar average values may be mapped to the same symbols, and the SAX distance between them is 0. In this paper, we propose a novel representation named SAX-BD (boundary distance) by integrating the SAX distance with a weighted boundary distance. The experimental results show that SAX-BD significantly outperforms the SAX representation, ESAX representation, and SAX-TD representation.
On the Solutions of Second-Order Differential Equations with Polynomial Coefficients: Theory, Algorithm, Application
Authors: Bryenton Kyle R. , Cameron Andrew R. , Kirk Keegan L. A. , Saad Nasser , Strongman Patrick , Volodin Nikita
Published: November 2020

The analysis of many physical phenomena is reduced to the study of linear differential equations with polynomial coefficients. The present work establishes the necessary and sufficient conditions for the existence of polynomial solutions to linear differential equations with polynomial coefficients of degree n, n−1, and n−2 respectively. We show that for n≥3 the necessary condition is not enough to ensure the existence of the polynomial solutions. Applying Scheffé’s criteria to this differential equation we have extracted n generic equations that are analytically solvable by two-term recurrence formulas. We give the closed-form solutions of these generic equations in terms of the generalized hypergeometric functions. For arbitrary n, three elementary theorems and one algorithm were developed to construct the polynomial solutions explicitly along with the necessary and sufficient conditions. We demonstrate the validity of the algorithm by constructing the polynomial solutions for the case of n=4. We also demonstrate the simplicity and applicability of our constructive approach through applications to several important equations in theoretical physics such as Heun and Dirac equations.
Self-Learning Salp Swarm Optimization Based PID Design of Doha RO Plant
Authors: Patnana Naresh , Pattnaik Swapnajit , Varshney Tarun , Singh Vinay Pratap
Published: November 2020

In this investigation, self-learning salp swarm optimization (SLSSO) based proportional- integral-derivative (PID) controllers are proposed for a Doha reverse osmosis desalination plant. Since the Doha reverse osmosis plant (DROP) is interacting with a two-input-two-output (TITO) system, a decoupler is designed to nullify the interaction dynamics. Once the decoupler is designed properly, two PID controllers are tuned for two non-interacting loops by minimizing the integral-square-error (ISE). The ISEs for two loops are obtained in terms of alpha and beta parameters to simplify the simulation. Thus designed ISEs are minimized using SLSSO algorithm. In order to show the effectiveness of the proposed algorithm, the controller tuning is also accomplished using some state-of-the-art algorithms. Further, statistical analysis is presented to prove the effectiveness of SLSSO. In addition, the time domain specifications are presented for different test cases. The step responses are also shown for fixed and variable reference inputs for two loops. The quantitative and qualitative results presented show the effectiveness of SLSSO for the DROP system.
Position Control with ADRC for a Hydrostatic Double-Cylinder Actuator
Authors: Wang Bin , Ji Hengyu , Chang Rui
Published: November 2020

A compact and flexible hydraulic double-cylinder actuation scheme is proposed for use in applications, especially where power density is extremely demanding. In view of flexible amounting requirements, long and thin hoses were utilized to connect two cylinders. Affecting the actuation preciseness, volume variation of the hoses caused by pressurized oil and bubbles was the main problem the system encountered. In this study, an active disturbance rejection control (ADRC) strategy was adopted for the improvement of displacement control performance under uncertain external load. After the experimental verification of the necessity of a hose model for the system, a centralized-parameter hose model was constructed where the coefficients are determined on the basis of the experimental data. Additionally, the system and the controller proposed were mathematically modeled. Simulation results shows that the system using ADRC exhibited higher displacement accuracy and better dynamic performance than that using PID (Proportion-Integral-Derivative) or fuzzy PID. ADRC has a stronger disturbance rejection ability. ADRC is an effective solution to nonlinear control of systems with uncertain parameters or various loads.
Agro-Morphological and Biochemical Characterization of Wild Prunus spinosa L. Subsp. dasyphylla (Schur) Domin Genotypes Naturally Grown in Western Black Sea Region of Turkey
Authors: Kuru Berk Selma , Tas Akgul , Orman Erdal , Gundogdu Muttalip , Necas Tomas , Ondrasek Ivo , Karatas Neva , Ercisli Sezai
Published: November 2020

In this study, agro-morphological, sensory and biochemical characteristics of 23 plum genotypes belonging to Prunus spinosa L. subsp. dasyphylla (Schur) Domin growing wild in the West Black Sea Region in Turkey were investigated. Agro-morphological, sensory and biochemical properties of genotypes were highly different from each other. Principal component analysis was performed to determine the correlation between these properties and genotypes. The variation in the study was determined to be 63.5% in agro-morphological properties, 53.8% in organic acids and 46% in phenolic compounds. In terms of fruit weight, 14BLM08 genotype (38.42 g) was determined to be superior to other genotypes. The fruit firmness value, which is important in the storage of fruits, was recorded as the highest in the 14BLM14 genotype (9.07 kg/cm2). Chlorogenic acid was higher than the other phenolic compounds and the highest value was obtained in the 14BLM20 (11.45 mg/kg) genotype. It was recorded that the value of malic acid, which is the major organic acid of the plums, varied between 269.65–1294.64 mg/100 g. Genotypes showed diverse vitamin C content, and the highest value was found in the 14BLM18 genotype as 54.42 mg/100g. Each genotype showed superiority according to the type of traits, and thus breeders may have used these genotypes as the superior ones for specific plum breeding purposes. In addition, these genotypes could be satisfactorily used in domestication.
Effect of a Heating System Using a Ground Source Geothermal Heat Pump on Production Performance, Energy-Saving and Housing Environment of Pigs
Authors: Mun Hong Seok , Dilawar Muhammad Ammar , Jeong Myeong Gil , Rathnayake Dhanushka , Won Jun Sung , Park Kwang Woo , Lee Sang Ro , Ryu Sang Bum , Yang Chul Ju
Published: November 2020

This study examined the effects of a heating system using a ground source geothermal heat pump (GHP). A GHP was installed in a pig house, and a comparative analysis was performed between the GHP and the control (conventional heating system) in terms of the production performance, housing environment, noxious gas emissions, electricity consumption, and economics. The geothermal system performance index, such as the coefficient of performance (COP), inlet, and outlet temperature, were also evaluated. The outflow temperature during each period (weaning, growing, and finishing) was significantly higher than the inflow temperature in all three components of the GHP system. Similarly, the average internal temperature of the GHP-connected pig house was increased (p < 0.05) during each period. The carbon dioxide (CO2) concentration, electricity usage, and cost of electricity during the 16-week experimental period were reduced significantly in the GHP system relative to the control. The concentrations of ammonia (NH3) during the growing and finishing period and the concentrations of formaldehyde during the weaning phase were also lower in the GHP-installed pig house (p < 0.05). These results indicate that the GHP system can be used as an environmentally friendly renewable energy source in pig houses for sustainable pig production without harming the growth performance.
The Greater Proportion of Born-Light Progeny from Sows Mated in Summer Contributes to Increased Carcass Fatness Observed in Spring
Authors: Liu Fan , Ford Erin M. , Morrison Rebecca S. , Brewster Chris J. , Henman David J. , Smits Robert J. , Zhao Weicheng , Cottrell Jeremy J. , Leury Brian J. , Dunshea Frank R. , Bell Alan W.
Published: November 2020

The backfat of pig carcasses is greater in spring than summer in Australia. The unexplained seasonal variation in carcass backfat creates complications for pig producers in supplying consistent lean carcasses. As a novel explanation, we hypothesised that the increased carcass fatness in spring was due to a greater percentage of born-light progeny from sows that were mated in summer and experienced hot conditions during early gestation. The first part of our experiment compared the birth weight of piglets born to the sows mated in summer (February, the Southern Hemisphere) with those born to sows mated in autumn (May; the Southern Hemisphere), and the second part of the experiment compared the growth performance and carcass fatness of the progeny that were stratified as born-light (0.7–1.1 kg) and born-normal (1.3–1.7 kg) from the sows mated in these two seasons. The results showed that the sows mated in summer experienced hotter conditions during early gestation as evidenced by an increased respiration rate and rectal temperature, compared with those mated in autumn. The sows mated in summer had a greater proportion of piglets that were born ≤1.1 kg (24.2% vs. 15.8%, p < 0.001), lower average piglet birth weight (1.39 kg vs. 1.52 kg, p < 0.001), lower total litter weights (18.9 kg vs. 19.5 kg, p = 0.044) and lower average placental weight (0.26 vs. 0.31 kg, p = 0.011) than those mated in autumn, although litter sizes were similar. Feed intake and growth rate of progeny from 14 weeks of age to slaughter (101 kg live weight) were greater for the born-normal than born-light pigs within the progeny from sows mated in autumn, but there was no difference between the born-light and normal progeny from sows mated in summer, as evidenced by the interaction between piglet birth weight and sow mating season (Both p < 0.05). Only the born-light piglets from the sows mated in summer had a greater backfat thickness and loin fat% than the progeny from the sows mated in autumn, as evidenced by a trend of interaction between piglet birth weight and sow mating season (Both p < 0.10). In conclusion, the increased proportion of born-light piglets (0.7–1.1 kg range) from the sows mated in summer contributed to the increased carcass fatness observed in spring.
Influence of Days in Milk and Parity on Milk and Blood Fatty Acid Concentrations, Blood Metabolites and Hormones in Early Lactation Holstein Cows
Authors: Van Quynh Chau Dang , Knapp Emilie , Hornick Jean-Luc , Dufrasne Isabelle
Published: November 2020

The objective of this paper is to study the influence of physiological factors that affect the energy balance, such as lactation stage and parity, on milk yield and composition, milk and blood fatty acid concentrations, blood metabolites and hormones in healthy early lactation cows. Thirty-two Holstein dairy cows from five Belgian commercial farms were followed. The grass silage-based diets fed to cows fell within normal composition ranges typically offered to dairy cows on commercial dairy farms in the region. Milk and blood were sampled at each official milk recording and used for the determination of milk fat and protein, milk and blood fatty acids, blood metabolites and hormones concentrations. The considered period was 7 to 150 days in milk. As lactation progressed, concentrations of milk 18:0 and 18:1c9, as well as blood non-esterified fatty acids and β-hydroxybutyrate, decreased, and those of milk C4–C14, blood cholesterol, triglycerides, insulin and IGF-I increased, agreeing with the extensive mobilization of body reserves in early lactation. Lower concentrations of milk C4–C14 and 16:0 and concomitant higher concentrations of milk 18:0 and 18:1c9 suggest a larger body reserve mobilization in first parity cows compared with greater than or equal to second parity cows. This study confirms that early lactation stage along with parity significantly influence milk fatty acids, such as 18:1, and blood metabolites and hormones, such as NEFA and insulin.
Growth Performance, Gut Environment and Physiology of the Gastrointestinal Tract in Weaned Piglets Fed a Diet Supplemented with Raw and Fermented Narrow-Leafed Lupine Seeds
Authors: Zaworska-Zakrzewska Anita , Kasprowicz-Potocka Małgorzata , Mikuła Robert , Taciak Marcin , Pruszyńska-Oszmałek Ewa , Frankiewicz Andrzej
Published: November 2020

The aim of this study was to: (1) provide controlled fermentation of narrow-leafed lupine seeds; (2) monitor seed composition, and (3) determine the influence of fermentation on the performance, gut environment and physiology, and selected blood metabolic parameters, in young pigs. Firstly, the effect of 24 h lupine seed fermentation by bacteria and yeast on seed chemical composition was determined. It increased contents of crude protein, crude fiber and ash, but reduced nitrogen-free extractive levels. The amino acid profile of fermented lupine (FL) was similar to that of raw lupine (RL) seeds, whereas the contents of oligosaccharides and P-phytate decreased significantly, in contrast to alkaloids. In fermented feed, pH dropped from 5.5 to 3.9. In the 28-day experiment, 24 male pigs were divided into three groups. The control group was fed a soybean meal diet (SBM), whereas in the experimental diets, 50% of SBM protein was replaced by RL or FL. Afterwards, eight pigs from each group were euthanized and their digesta and blood samples were collected. The FL use did not affect pigs’ performance, nor their metabolic, microbial and most gastrointestinal tract parameters, but influenced crypt depth. Fermentation affected concentrations of short chain fatty acids and p-cresole in the proximal colon segment. In the small intestine, the levels of acetate and butyrate decreased, and, in the caecum, the propionate level decreased. Fermentation significantly lowered the pH of the middle colon digesta and ammonia contents compared to RL. A part of SBM may be successfully replaced by RL and FL in young pigs’ diets.
Upregulation of Peroxiredoxin-2 in Well-Differentiated Pancreatic Neuroendocrine Tumors and Its Utility as a Biomarker for Predicting the Response to Everolimus
Authors: Kim Eui Joo , Kim Yoon Jae , Lee Hye In , Jeong Seok-Hoo , Nam Hyo Jung , Cho Jae Hee
Published: November 2020

Pancreatic neuroendocrine neoplasms (pNENs) account for 2–3% of pancreatic malignancies. Peroxiredoxins (Prdxs), which are major cellular antioxidants, are involved in multiple oncogenic signaling pathways. We investigated the role of peroxiredoxin-2 in QGP-1 human pNEN cell line and patient-derived pNEN tissue. To validate the cancer stem cell-like cell characteristics of QGP-1 cells in spheroid culture, in vitro analyses and xenografting were performed. Furthermore, immunohistochemical staining was conducted to verify the overexpression of Prdx2 in pNEN tissue. Prdx2 expression was high at the mRNA and protein levels in QGP-1 cells. Prdx2 was also overexpressed in patient-derived pNEN tissue. Silencing of Prdx2 using siRNA induced overexpression and phosphorylation of ERK and AKT in QGP-1. Cell proliferation was increased by treating QGP-1 cells with siPrdx2, and the IC50 of everolimus increased suggesting resistance to everolimus. Interestingly, QGP-1 spheroid cells, which exhibited cancer stem cell-like features, exhibited lower expression of Prdx2 and mTOR. The results suggest that Prdx2 expression level and its activity may be a potential predictive biomarker for therapeutic response or resistance to everolimus in pNEN.
Milk Protein-Derived Antioxidant Tetrapeptides as Potential Hypopigmenting Agents
Authors: Kong Saerom , Choi Hye-Ryung , Kim Yoon-Jeong , Lee Yoon-Sik , Park Kyoung-Chan , Kwak Seon-Yeong
Published: November 2020

Excessive accumulation of melanin can cause skin pigmentation disorders, which may be accompanied by significant psychological stress. Although many natural and synthetic products have been developed for the regulation of melanogenesis biochemistry, the management of unwanted skin pigmentation remains challenging. Herein, we investigated the potential hypopigmenting properties of peptide sequences that originated from milk proteins such as ĸ-casein and β-lactoglobulin. These proteins are known to inhibit melanogenesis and their hydrolysates are reported as antioxidant peptides. We synthesize tetrapeptide fragments of the milk protein hydrolysates and investigate the amino acids that are essential for designing peptides with tyrosinase inhibitory and antioxidant activities. We found that the peptide methionine-histidine-isoleucine-arginine amide sufficiently inhibits mushroom tyrosinase activity, shows potent antioxidant activity and effectively impedes melanogenesis in cultured melanocytes via cooperative biological activities. Our findings demonstrate the potential utility of the bioactive tetrapeptide from milk proteins as a chemical alternative to hypopigmenting agents.
Accumulation of Methylmercury in the High-Altitude Lake Uru Uru (3686 m a.s.l, Bolivia) Controlled by Sediment Efflux and Photodegradation
Authors: Guédron Stéphane , Achá Dario , Bouchet Sylvain , Point David , Tessier Emmanuel , Heredia Carlos , Rocha-Lupa Stéfany , Fernandez-Saavedra Pablo , Flores Marizol , Bureau Sarah , Quino-Lima Israel , Amouroux David
Published: November 2020

In shallow aquatic environments, sediment is a significant source of monomethylmercury (MMHg) for surface water (SW). High-altitude aquatic ecosystems are characterized by extreme hydro-climatic constraints (e.g., low oxygen and high UV radiation). We studied, during two seasons, the diel cycles of MMHg in SW and sediment porewaters (PW) of Lake Uru Uru (3686 m a.s.l, Bolivia) contaminated by urban and mining activities. Our results show that diel changes in SW MMHg concentrations (up to 1.8 ng L−1) overwhelm seasonal ones, with higher MMHg accumulation during the night-time and the dry season. The calculation of MMHg diffusive fluxes demonstrates that the sediment compartment was the primary source of MMHg to the SW. Most MMHg efflux occurred during the dry season (35.7 ± 17.4 ng m−2 day−1), when the lake was relatively shallow, more eutrophicated, and with the redoxcline located above the sediment–water interface (SWI). Changes in MMHg accumulation in the PWs were attributed to diel redox oscillations around the SWI driving both the bacterial sulfate reduction and bio-methylation. Finally, we highlight that although MMHg loading from the PW to the SW is large, MMHg photodegradation and demethylation by microorganisms control the net MMHg accumulation in the water column.
On the Use of Importance Measures in the Reliability of Inventory Systems, Considering the Cost
Authors: Chen Liwei , Kou Meng , Wang Songwei
Published: November 2020

In order to maximize inventory benefits or minimize costs, reliability and cost of inventory control models need to be identified and analyzed. These importance measures are one important approach to recognize and evaluate system weaknesses. However, importance measures have fewer applications in inventory systems’ reliability. Considering the cost, this paper mainly discusses the reliability change of performance parameters with the importance measures in inventory systems. The calculation methods of differential importance and Birnbaum importance are studied in the inventory control model with shortages. By comparing the importance values of various parameters in the model, the optimization analysis of the inventory model can be used to identify the key parameters, so as to effectively reduce the total inventory cost. The importance order and the identification of key parameters are helpful to increase the operational efficiency of the inventory control and provide effective methods for improving the inventory management. Lastly, a case study with a shortage and limited inventory capacity is used to demonstrate the proposed model.
A Convenient Unified Model to Display the Mobile Keyhole-Mode Arc Welding Process
Authors: Li Yan , Su Chen , Wang Ling , Wu Chuansong
Published: November 2020

Keyhole-mode plasma arc welding (PAW) has a good prospect in the manufacturing industry. Unified models of plasma arc and workpiece help to reveal the physical mechanism in PAW for a better application. Previous unified models either deal with a constant keyhole situation or take too much computational time to display the dynamic keyhole process with a two-phase flow method. In view of the convenience for industrial application as well as good accuracy, a convenient unified model was developed to describe the mobile keyhole-mode PAW. With a simplified technique, the multiphase heat and force effect between plasma arc and workpiece was turned into a single-phase problem at each individual domain. Thus, it takes less computational time than previous unified models. The temperature field and weld pool during the mobile keyhole-mode PAW process were revealed, the arc flow and pool flow were displayed and the electric potential was predicted. The experiment was conducted on a stainless-steel plate, and the weld pool image and the measured arc pressure agree well with the calculated result. The calculated electric potential drop also coincides with the experiment. The model provides a convenient and accurate method to display the mobile keyhole-mode arc welding process.
Experimental Devices to Investigate the Long-Term Stability of Phase Change Materials under Application Conditions
Authors: Rathgeber Christoph , Hiebler Stefan , Bayón Rocío , Cabeza Luisa F. , Zsembinszki Gabriel , Englmair Gerald , Dannemand Mark , Diarce Gonzalo , Fellmann Oliver , Ravotti Rebecca , Groulx Dominic , Kheirabadi Ali C. , Gschwander Stefan , Höhlein Stephan , König-Haagen Andreas , Beaupere Noé , Zalewski Laurent
Published: November 2020

An important prerequisite to select a reliable phase change material (PCM) for thermal energy storage applications is to test it under application conditions. In the case of solid–liquid PCM, a large amount of thermal energy can be stored and released in a small temperature range around the solid–liquid phase transition. Therefore, to test the long-term stability of solid–liquid PCM, they are subjected to melting and solidification processes taking into account the conditions of the intended application. In this work, 18 experimental devices to investigate the long-term stability of PCM are presented. The experiments can be divided into thermal cycling stability tests, tests on PCM with stable supercooling, and tests on the stability of phase change slurries (PCS). In addition to these experiments, appropriate methods to investigate a possible degradation of the PCM are introduced. Considering the diversity of the investigated devices and the wide range of experimental parameters, further work toward a standardization of PCM stability testing is recommended.
Influence of Buckwheat and Buckwheat Sprouts Flours on the Nutritional and Textural Parameters of Wheat Buns
Authors: Sturza Alina , Păucean Adriana , Chiș Maria Simona , Mureșan Vlad , Vodnar Dan Cristian , Man Simona Maria , Urcan Adriana Cristina , Rusu Iulian Eugen , Fostoc Georgiana , Muste Sevastița
Published: November 2020

In recent years, food products manufactured with buckwheat and sprouts flours have attracted widespread interest due to their high nutritional value with various health benefits, becoming more and more popular. The purpose of this study was to assesses the influence of buckwheat and sprouts flours on the nutritional, sensorial and textural characteristics on the final baked products. In order to achieve these goals, methods like HPLC-RID (High-Perfomance Liquid Chromatography with Refractive Index Detection), aluminum chloride colorimetric assay, Folin-Ciocalteu and 1,1-Diphenyl-2-picrylhydrazyl (DPPH) were used to determine fructose, glucose, sucrose, maltose; total flavonoids, total phenols and antioxidant activity. Sensorial analysis was realized by using hedonic test and texture profile was performed on a CT 3 Texture Analyzer. The results proved that wheat flour could be successfully replaced by 20% buckwheat and 10% sprouts flours, respectively, improving their nutritional value, without negative influence on texture parameters and sensorial features. The obtained buns were accepted by consumers with a total hedonic score of 9.1 and 8.7, respectively. Hardness, gumminess and adhesiveness were improved by using Magimix improver, meanwhile cohesiveness, springiness, gumminess and adhesiveness were improved by using guar gum.
Multiplate® Platelet Aggregation Findings Are Dependent on Platelet Count but Can Be Corrected by Use of a Ratio
Authors: Soliman Mohamed , Hartmann Matthias
Published: November 2020

Impedance aggregometry (Multiplate®) detects the effects of platelet aggregation inhibitors and can predict thrombotic complications after coronary and cerebrovascular stent interventions. The bedside method uses whole blood samples not corrected for platelet count. It is claimed but not proved that the findings are unrelated to platelet count in the physiological range. We therefore investigated in the experimental study: (1) whether impedance aggregometry findings and platelet count are correlated and (2) whether the aggregation/platelet count ratio expresses platelet function independent of platelet count. Following ethics committee approval, platelet-rich plasma from healthy probands was diluted with platelet-poor plasma to obtain different platelet counts. Thereafter, platelet count was measured and samples were subjected to impedance aggregometry using thrombin receptor activating peptide (TRAP) for platelet activation. In all probands, impedance aggregometry findings and platelet count were highly correlated (r = 0.88 to 0.94; p < 0.05). The combination of all experiments revealed the proportionality between impedance aggregometry findings and platelet count (n = 31, r = 0.78, p = 0.0001). In contrast, the ratio of impedance aggregometry findings and platelet count was not significantly correlated with platelet count (r = 0.017; p = 0.3) and thus constitutes a specific measure for platelet function. In conclusion, impedance aggregometry findings subsequent to the activation with TRAP are dependent on both platelet function and platelet count. Normalization of impedance aggregometry findings for platelet count can be achieved by a ratio resulting in more specific results.
BIM-Based Educational and Facility Management of Large University Venues
Authors: Pavón Rubén Muñoz , Arcos Alvarez Antonio A. , Alberti Marcos G.
Published: November 2020

The aim of this paper was to provide a Building Information Modeling (BIM)-based management system for the Civil Engineering School (ETSICCP) at the Universidad Politécnica de Madrid with a long-term development perspective. A Building Information Modeling (BIM) management system for complex infrastructure facilities demands a detailed 3-Dimensional model according to future management requirements. In this study, the infrastructure of the ETSICCP was modeled on various phases and synchronized with not only external educational information but also with facility management (FM) parameters. The methodology followed in this study ranges from the blank paper to a BIM-based detailed FM system oriented to educational scheduling throughout the infrastructure providing real time information synchronized with spreadsheets and a 3-D model. The result of this paper provides multiples future management lines, like COVID-19 BIM-management or synchronization with local public transports’ applications (mainly metro and bus transport systems), through a public accessible Application Programming Interface (API). The significance of this research relies on the generation of an information and management system, based on a BIM model of a university campus. This project was designed for all the agents involved in its operation, students, lecturers, and managers. All these agents have a level of access appropriate to their needs and functions within the institution.