bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel Alkyl Thioether Cyclodextrin Derivatives Against Bacterial Quorum Sensing in Aliivibrio fischeri
Authors: Fenyvesi Eva , Berkl Zsófia , Ligethy Laura , Fekete-Kertész Ildikó , Csizmazia Márton , Malanga Milo , Puskás István , Szőcs Levente , Varga Erzsébet , Szente Lajos , Molnár Mónika
Published: January 2023

Aliivibrio fischeri is a heterotrophic marine bacterium capable of bioluminescence which is controlled by quorum sensing. Quorum sensing is a population density dependent communication method for the bacteria to coordinate their activities by producing and detecting low-molecular-weight signal molecules. The effective infectivity of the bacteria is based on various virulence factors controlled by quorum sensing. Cyclodextrins, a family of toroidal-shaped oligosaccharides, reversibly encapsulate in their hydrophobic interior the fatty acid acyl chain of the signal molecules, thus preventing their binding to the receptors and interrupting the bacterial communication consequently the expression of various properties including different virulence factors.

Short-term tests were performed to examine the potential quorum quenching ability of newly prepared cyclodextrin derivatives: α- and β-cyclodextrins monosubstituted with alkylthio moieties. In these derivatives one of the modifiable hydroxyl groups of the cyclodextrin molecule is substituted with an alkylthio group of six, ten, twelve or sixteen carbon atoms. Cyclodextrins at 1.563–12.5 mM concentrations were added to A. fischeri culture in exponential growth phase, then the bioluminescence intensity, the population growth and the cell viability were kept under systematic review.

According to our results, the cyclodextrins have inhibitory effect on the quorum sensing system of A. fischeri, the alkylthio-substitution improves this effect compared to the native molecules and the length of the alkyl chain has significant influence on the quorum quenching efficiency.
Comparative and Global Perspectives on Environmental Fund: A Blueprint for the Establishment of Environmental Fund in Nigeria
Authors: Udok Uwem , Umeojiako Mulumba Chigozie , Ikott Akwaowo J.
Published: January 2023

The Nigerian economy has been described as a mono-economy as it relies mainly on the proceeds from crude oil production as the source of revenue to fund government policies and programmes. Exploration and production of crude oil in the country have continued over the years leading to increased activities and growth of the oil industry. The production of oil and gas in the country has had enormous impact on the environment sometimes leading to oil pollution which has adversely affected human lives, plants and animals, social and economic lives of the people living in the affected areas. Findings have shown that though there are laws that protect the environment but these laws do not provide for compensation to victims of oil pollution in the country. Therefore, the victims are left to seek redress in the court of law for remedy, which in most cases, the victims are confronted with a lot of challenges. These challenges make it difficult for the victims to get compensation for loss or damage suffered by them and sometimes, the court awards compensation that is not commensurate with the extent of loss or damage incurred by the victims. Therefore, an alternative measure to ensure that the victims of oil pollution are able to obtain relief becomes a compelling necessity as it is obtainable in other jurisdictions. This work concludes that unless Nigeria adopts the best practice in compensating victims of oil pollution in the oil producing communities, the victims of oil pollution will continue to suffer without adequate compensation or no compensation for the destruction of their means of livelihood. This work, therefore, recommends, the establishment of environmental fund to compensate victims of oil pollutions in Nigeria.
Psychological impact of the SARS-CoV-2 pandemic on the mental health of university students - PRISMA Systematic Review
Authors: Ala Sílvia , Ramos Francisco , Relva Inês
Published: January 2023

Review question / Objective: Our goal will be to assess the impact on mental health of university students by comparing data from studies during and after contingency measures imposed to contain the spread of the SARS-CoV-2 coronavirus and to identify potential risk and protective factors for mental health. The results will be important for designing appropriate psychological interventions and mental health resources needed by university students. The research question was constructed following the PECO strategy. P=Population includes university students. E= exposure comprises contingency measures (confinement/social isolation/quarantine). C= comparison of studies conducted during and after the contingency measures (confinement/social isolation/quarantine) imposed by the pandemic of COVID-19. O= outcome immediate effect or consequences such as psychological impacts (depression, stress, anxiety, well-being, fear, burnout). Thus, the main question to be asked is: "What is the psychological impact caused by the Sars-Cov-2 pandemic on students' mental health during and after the contingency/restriction measures (confinement/social isolation/quarantine)?"
La junta de saneamiento como factor importante en el desarrollo comunitario
Authors: Ayala Cardozo Gabriela
Published: January 2023

La Junta de Saneamiento es una institución gubernamental en Paraguay cuyo objetivo es mejorar la calidad de vida de las comunidades a través de la promoción de proyectos de desarrollo y saneamiento ambiental. En los últimos años, se ha demostrado que la participación activa de la Junta de Saneamiento en la toma de decisiones y la implementación de proyectos en las comunidades es un factor clave para el desarrollo sostenible y el bienestar de la población (Rodríguez & Martínez, 2020). Sin embargo, a pesar de su importancia, la Junta de Saneamiento a menudo enfrenta desafíos en su labor debido a la falta de recursos y la falta de participación ciudadana (González et al., 2019). Es por eso que es crucial que se aborde de manera proactiva estos obstáculos y se promueva la colaboración entre la Junta de Saneamiento, las comunidades y otros actores clave en el desarrollo comunitario. En este artículo, exploraremos la importancia de la Junta de Saneamiento como factor en el desarrollo comunitario y discutiremos algunos de los desafíos y oportunidades que enfrenta en su labor a partir de la revisión de publicaciones en plataformas de difusión de artículos científicos como Scopus, Scielo y Latindex. Además, presentaremos algunas estrategias y enfoques innovadores que pueden ayudar a superar estos obstáculos y promover el desarrollo sostenible en las comunidades
Políticas de primera infancia y buen estado de salud: un análisis reflexivo
Authors: Albán Bermejo Angela Esther , Contreras Rivera Robert Julio , Heredia Escobar Wilman Jorge , Reyes Castillo Eduardo Antonio
Published: January 2023

El presente estudio nombrado Políticas de primera infancia y el buen estado de salud contempla una reflexión crítica a la relevancia que tiene para el progreso de una nación atender oportunamente y de manera adecuada la salud de los niños pequeños en edades tempranas. Esta atención a tiempo y apropiada sentaría las bases cognitivas, relacionales y socioemocionales, aseverando el desarrollo integral de los niños que posteriormente cimentarán un país acrecentado en valores de justicia, ética y lleno de oportunidades. Inclinarnos hacía un enfoque cualitativo favoreció la reflexionar sobre las variables consignadas en el estudio, llevando a utilizar el método inductivo y también analítico favoreciendo el análisis documental. Las reflexiones conclusivas invitan al Estado a tener una mirada horizontal con enfoque territorial a la niñez en la primera infancia para asegurar el buen estado de salud que redunda en una sociedad más justa, equitativa, productiva, con mayores oportunidades laborales y económicas que favorecerían el crecimiento pleno del país.
Resistencia del concreto con incorporación de fibras de caña de azúcar y ceniza de carbón de madera
Authors: Laban Guerrero Emigdio Absalon , Clemente Condori Luis Jimmy , Choque Flores Leopoldo
Published: January 2023

En este estudio se evalúa el efecto de la combinación de la adición de fibras de caña de azúcar y ceniza de carbón, cuya procedencia es producto de residuos orgánicos, los cuales van a ser incorporados en la mezcla del concreto con el objetivo de poder mejorar su resistencia a compresión y tracción como objetivos de primer nivel y de segundo nivel verificar su trabajabilidad y densidad del concreto. La dosificación de las fibras fue reemplazada respecto al peso del agregado fino, en cambio la proporción de ceniza fue reemplazada respecto al peso del cemento. La estructura para el desarrollo de la investigación estuvo conformada por dos fases; en la primera fase se realizó la caracterización de los agregados utilizados en la elaboración del concreto, mientras que, en la segunda fase se realizaron ensayos para determinar la resistencia a compresión y tracción para tres dosificaciones del 0.5%, 1%, 2% de fibras y el 2.5%, 5%, 7% de ceniza, además de la mezcla patrón para evaluar la resistencia óptima. En base a los resultados obtenidos, se llegó a concluir que la influencia de la adición de las fibras y ceniza tiene mayor afectación sobre la resistencia del concreto.
Efectividad de la gestión pública y calidad de servicio de programas preventivos de salud bucal: Una revisión sistemática
Authors: Capcha Cóndor John Carlos , Mendez Ilizarbe Dr. Gliria Susana , Flores Yallico Carmen Pilar , Flores Yallico Gennma Lucila , Ubillús Farfán Segundo Williams
Published: January 2023

Este estudio tuvo como objetivo realizar una revisión sistemática sobre la efectividad de la gestión pública y la calidad de servicio de programas preventivos de salud bucal. Se planteó un estudio cualitativo, básico y de diseño fenomenológico. La población estuvo compuesta de 4731 artículos publicados en revistas indexadas en diferentes bases de datos como Scopus, PubMed, ProQuest, SciELO, entre otras; y se trabajó con 12 artículos que fueron seleccionados empleando la técnica del análisis documental. Los resultados mostraron que los programas de prevención en salud bucal logran reducir la prevalencia de enfermedades como caries, aplicándolos como programas educativos de hábitos saludables, de técnicas de cepillado y de importancia, elevando el nivel de conocimiento y la salud bucal de los beneficiarios. Además, se evidenció que factores como la falta de medicamentos, de insumos, la infraestructura inadecuada y el salario insuficiente de los trabajadores de salud son factores que inciden en la tangibilidad que termina por definir a la calidad de servicio. Se concluyó que los programas de prevención de la salud bucal son importantes para mejorar la prevalencia de enfermedades bucodentales, y que es necesario fortalecer los estudios relacionados con la calidad de servicio siendo una recomendación para los futuros investigadores.
Uso de las TIC en la práctica pedagógica con estudiantes de secundaria de Huancayo-2022
Authors: Ccahuana Chocce Esperanza
Published: January 2023

En un contexto de avances vertiginosos, la era digital alcanza a la sociedad en su conjunto escenarios cambiantes fluctuantes, por ello se ha vuelto necesario la utilización de las TIC en la praxis del docente, lo que conlleva a una serie de acciones que se desarrolla en atención a lo que requiere el estudiante en el devenir diario. Se pone a consideración este estudio, cuya finalidad es evaluar al docente que desarrolla la práctica desde al ámbito pedagógico con un recurso muy especial que son las TIC, con estudiantes de secundaria de Huancayo. Se observó características fundamentales que atañen a la práctica pedagógica de los docentes de las diferentes áreas con el uso de las TIC.
Relación entre el estilo divergente y aprendizaje en los estudiantes I ciclo de la escuela de sistemas de la universidad César Vallejo – sede Piura
Authors: Sernaqué Barrantes Marleny , Talledo Mendoza Gulissa Graciela , Herrera Mogollón Rosa Tomasita
Published: January 2023

En esta investigación se fórmula la dificultad: ¿Cuál es la relación entre el estilo divergente y aprendizaje en los estudiantes I ciclo de la escuela de sistemas de la Universidad César Vallejo – Sede Piura? Para lo cual tiene un fin general: Establecer la relación entre el estilo divergente y el aprendizaje en los estudiantes I ciclo de la escuela sistemas. El estudio es de diseño no experimental, tipo correlacional, nível descriptivo, método deductivo, las variables tienen relación directa. Se planteó usar actividades de observación reflexiva y de experiencia concreta. La población y muestra censal de 27 estudiantes I ciclo de sistemas. Con una muestra poblacional. Para la recolección de datos se utilizó como técnica la encuesta como instrumento se aplicó el cuestionario de aprendizaje del autor David Kolb. Con la valoración de escala de Likert. La estadística se elaboró en base a tablas que reflejan el porcentaje de relación directa, con su respectivo análisis y discusión. Se logró establecer la relación entre el estilo divergente y el aprendizaje en los estudiantes I ciclo de la Escuela de Sistemas, se describe que de los 27 estudiantes que formaron parte del tiempo real, el 90 % de ellos presentan un nivel de aprendizaje suficiente, de los cuales el 80% tienen un buen estilo divergente y un 10% un nivel regular.
Estrategias de subsistencia aplicadas por los comerciantes del mercado municipal de la ciudad de Pilar durante el año 2022
Authors: Ayala Ortiz Bettiana Gisselle
Published: January 2023

Este trabajo de investigación fue realizado en la ciudad de Pilar, capital del departamento de Ñeembucú, con el objetivo de analizar las estrategias de subsistencia que aplican los comerciantes del mercado municipal de la ciudad, para hacer frente a la coyuntura económica actual. El mercado municipal es considerado un punto de encuentro económico muy importante debido a la ubicación estratégica, costos accesibles, y la cordial atención de sus comerciantes. El universo de estudio, estuvo conformado por 25 comerciantes, cuya muestra aplicada fue de 17, y 5 informantes claves de la institución municipal de modo a diversificar la fuente de información y obtener resultados más precisos ante las interrogantes planteadas.

La metodologia responde al enfoque mixto, utilizando técnicas de enfoque cuantitativo (encuesta, observación) y cualitativo (entrevista, revisión documental). Se desarrolló con un estudio de tipo descriptivo, ya que se limitó a describir de modo sistemático las características de una población, situación o área de interés. La investigación se circunscribió dentro de un estudio no experimental de corte transversal, fue aplicada una técnica de muestreo no probabilístico intencional, el análisis de datos se realizó a través de la técnica de análisis descriptiva por variables.
Funcionamiento del régimen interno de exportación de la aduana de Pilar
Authors: Díaz Sánchez Silvia Micaela , Arguello Silva Luis Martín
Published: January 2023

Las aduanas son las instituciones encargadas del control de productos que salen e ingresan al país, las exportaciones cumplen un rol relevante en la situación económica del mismo y se convierte en tema de análisis permanente en esta sociedad globalizada. Considerando que, tanto empresas privadas como la Administración Nacional de Navegación y Puertos han invertido en la infraestructura necesaria, la Dirección General de Aduanas, hace unos años, ha habilitado en la ciudad de Pilar, la exportación de productos nacionales, consolidándose como mecanismo facilitador del comercio internacional. La investigación tiene como objetivos conocer el funcionamiento de las distintas dependencias de la Aduana de Pilar, indagar los principales productos exportados y el destino de los mismos e identificar el impacto social ocasionado por las actividades de exportación en la ciudad de Pilar. Es un estudio de caso con enfoque cualitativo, descriptivo, de corte trasversal, muestreo no probabilístico, tipo de muestreo intencional. Los datos se obtienen por medio de revisión documental, entrevistas y cuestionario, y éstos demuestran que la Aduana de la ciudad de Pilar cuenta con una organización adecuada, se conoce los principales productos exportados, el destino de los mismos, y la importancia social de esta importante labor.
Análisis de los principios de la evaluación del desempeño docente y la adopción del enfoque socioformativo
Authors: Trixie Velazco Mareco Liliana Olivia
Published: January 2023

Esta investigación se centra en la discusión sobre la evaluación del desempeño docente, la eficiencia en su implementación contrastado con sus principios y la propuesta de ser aplicado con un enfoque denominado Socioformativo como aporte de la construcción de un proceso más participativo abocado a generar cambios por medio de proyectos de formación para los docentes. La hipótesis es la ineficiencia en la implementación de las evaluaciones del desempeño docente y acompañamiento con capacitaciones en base a debilidades que contribuyan a lograr mejores competencias en los docentes. La investigación es bibliográfica, se procedió a la revisión de artículos de diversos autores sobre el tema accediendo a ellos por medio de Google Académico y por el portal CICCO de CONACYT Paraguay. La conclusión derivada del trabajo fue la necesidad de incorporar como enfoque pertinente, actual y sobre todo conformado por un elemento muy importante que es el cognitivo las evaluaciones desde el enfoque de la Socioformación; también es preciso cumplir con todos los procesos, si bien, se pueden llevar a cabo las evaluaciones, este enfoque claramente propone la definición de Proyectos de Formación los cuales necesariamente precisan del involucramiento de más actores y del compromiso institucional por medio de los tomadores de decisiones.
Estrés laboral y satisfacción sexual en personal sanitario
Authors: Coello Hernandez Damaris Leidy , Gavilanes Manzano Psc. Mg. Fanny Rocío
Published: January 2023

El estrés laboral y la satisfacción sexual representan un problema significativo en la sociedad moderna debido a que puede afectar notablemente en la calidad de vida de los trabajadores, además de ser una asociación que no ha sido estudiada a profundidad, por esta razón la presente investigación tuvo como objetivo determinar la relación entre estrés laboral y satisfacción sexual en el personal sanitario, mediante un enfoque cuantitativo, de alcance correlacional, diseño no experimental de corte transversal, en una muestra conformada de 100 profesionales pertenecientes al área de salud (40% hombres y 60% mujeres) seleccionados mediante un muestreo no probabilístico a quienes se les aplicó la escala de estrés laboral OIT- OMS y la nueva escala de satisfacción sexual (NSSS). Los resultados obtenidos identificaron la predominancia de estrés, así como nivel medio de satisfacción sexual sin diferencias estadísticamente significativas entre hombres y mujeres con relación a la variable satisfacción sexual (t (98.0) = -1.56, p >0.05). Además, existe una relación negativa leve entre estrés laboral y satisfacción sexual (Rho= -0.427 p < .001). Se concluyó que a mayor estrés laboral menor satisfacción sexual.
Rancang Bangun Sistem Informasi Training Online Berbasis Web (Studi Kasus: Upt Lab. Komputer STMIK Prabumulih)
Authors: Khana Khana Wijaya
Published: January 2023

Lembaga kursus yang ada pada Upt Lab. Komputer STMIK Prabumulih adalah sebuah lembaga yang bergerak dalam jasa training (kursus) komputer, yang diselenggarakan secara tatap muka, dimana pusat training STMIK Prabumulih menyediakan tempat serta sarana dan prasarana untuk menyelenggarakan training secara tatap muka. training adalah usaha pengembangan keterampilan mahasiswa yang dilakukan oleh UPT Lab Komputer untuk mencapai standar tertentu khususnya di bidang pemrograman. Aplikasi adalah perangkat lunak yang menggabungkan beberapa fitur tertentu dengan cara yang dapat diakses oleh pengguna. Perkembangan internet dari tahun ke tahun mengalami peningkatan dari sisi pengguna aktifnya. Setiap orang tentu mengakses internet dengan menggunakan berbagai perangkat, mulai dari desktop, mobile, hingga tablet. Dan website adalah salah satu media yang paling sering untuk diakses dan digunakan dalam mencari berbagai informasi dan sarana komunikasi. Web adalah kumpulan halaman dalam suatu domain yang memuat tentang berbagai informasi agar dapat dibaca dan dilihat oleh pengguna internet melalui sebuah mesin pencari. Informasi yang dapat dimuat dalam sebuah website umumnya berisi mengenai konten gambar, ilustrasi, video, dan teks untuk berbagai macam kepentingan. Oleh karena itu, dibutuhkannya sebuah aplikasi berbasis web training online yang dapat digunakan untuk megakses media pembelajaran secara online dan dapat dilakukan kapanpun dan dimanapun. Meskipun pembelajaran dilakukan secara online, masih ada biaya yang harus dikeluarkan oleh peserta untuk membeli paket training dan mengakses media pembelajaran secara online. Dengan dirancangnya sistem informasi training online ini maka akan dapat membantu instruktur dalam memberikan materi kepada peserta, sehingga peserta dan instruktur dapat dengan mudah melakukan interaksi jarak jauh.
Perancangan Website Penjadwalan Piket Kebersihan di Diskominfo Kabupaten Kediri
Authors: Septian Tito Reymar  , Ferdi Chandra Fitrian Saputra  , Halimahtus Mukminna
Published: January 2023

Menjaga kebersihan lingkungan kerja dilakukan agar pekerja nyaman dengan lingkungan pekerjaanya. Pekerja yang nyaman dengan lingkungan kerjanya cenderung memiliki motivasi lebih tinggi dalam melakukan pekerjaanya. Lingkungan kerja dibersihkan oleh seorang petugas kebersihan. Untuk memudahkan petugas kebersihan dalam membersihkan suatu lingkungan kerja, perlu dilakukan penjadwalan kebersihan. Pada Diskominfo kabupaten Kediri, belum terdapat penjadwalan piket kebersihan yang terstruktur. Penjadwalan biasanya dilakukan oleh petugas kebersihan sendiri. Sehingga Petugas kebersihan terkadang mengalami kesulitan dalam mengingat tempat mana saja yang sudah dibersihkan atau yang belum dibersihkan pada gedung Diskominfo kabupaten Kediri. Website dibuat dengan harapan membantu persoalan yang dialami petugas kebersihan di Diskominfo kabupaten Kediri. Pembuatan website dilakukan dengan menggunakan metode waterfall. Dari Hasil pengujian yang dilakukan, website berhasil menyimpan dan menampilkan data sesuai dengan yang diharapkan, sehingga disumpulkan website layak untuk digunakan.
PENGARUH UPAH TERHADAP KINERJA KARYAWAN PADA PT ADIRA FINANCE CABANG SUBANG
Authors: Ma’ruf Kamal , Aulia Silvi , Ardiana Mega
Published: January 2023

Abstrak

PT Adira Finance Cabang Subang memiliki misi menjadi perusahaan pembiayaan sepeda motor resmi yang mampu memberikan kualitas dan pelayanan terbaik, dengan mempunyai sertifikat ISO, dan type sepeda motor yang dijual oleh PT Adira Finance Cabang Subang. Penelitian ini dilaksanakan di PT Adira Finance Cabang Subang. Jenis penelitian ini adalah jenis data penelitian kuantitatif dengan menggunakan metode penelitian deskriptif dan verifikatif. Populasi penelitian ini adalah 100 karyawan . Teknik pengumpulan data yang digunakan adalah wawancara, angket, observasi lapangan, studi pustaka. Analisis data yang digunakan adalah analisis data deskriptif, analisis korelasi dan koefisien determinasi. Penelitian ini bertujuan untuk mengetahui pengaruh Upah Terhadap Kinerja Karyawan di PT Adira Finance Cabang Subang. Hasil penelitian menunjukan bahwa koefisien antara upah terhadap Kinerja Karyawan di PT Adira Finance Cabang Subang sebesar 078,1% artinya bahwa Kinerja pegawai di PT Adira Finance dipengaruhi oleh Upah pegawai (X) 78,1% dan sisanya sebesar 22,9% dipengaruhi faktor-faktor lain yang tidak diteliti dalam penelitian ini.

 

Kata Kunci: Upah, Kinerja, Karyawan

 

 

Abstract

 

PT Adira Finance Subang Branch has a mission to become an official motorcycle financing company that is able to provide the best quality and service, by having an ISO certificate, and the type of motorcycle sold by PT Adira Finance Subang Branch. This research was conducted at PT Adira Finance Subang Branch. This type of research is a type of quantitative research data using descriptive and verification research methods. The population of this research is 100 employees. Data collection techniques used are interviews, questionnaires, field observations, literature studies. The data analysis used is descriptive data analysis, correlation analysis and coefficient of determination. This study aims to determine the effect of wages on employee performance at PT Adira Finance Subang Branch. The results show that the coefficient between wages and employee performance at PT Adira Finance Subang Branch is 078.1%, meaning that employee performance

at PT Adira Finance is influenced by employee wages (X) 78.1% and the remaining 22.9% is influenced by other factors. other factors not examined in this study

Keywords: Wages, Performance, Employee
An overview of advances in glass ionomer cements
Authors: Saridena Udaya Sri Naga Gayatri , Sanka Gnana Siva Sai Jayalaksmi , Alla Rama Krishna , Ramaraju AV  , MC Suresh Sajjan , Raju Mantena Satyanaryana
Published: January 2023

Glass-ionomer dental cements (GICs) are aesthetic direct restorative materials with anticariogenic activity. Glass-ionomers are composed of alumino-silicate glass powder and poly acrylic acid liquid. The significant characteristics of GICs among restorative materials are their ability to bond to moist tooth structure without any pre-treatment and to provide a prolonged period of fluoride release, which prevents subsequent tooth decay (caries). These characteristics, along with the materials' acceptable aesthetics and biocompatibility, make them popular and desirable for use in medical and dental applications. However, GICs exhibit poor mechanical qualities and moisture sensitivity. To improve their mechanical and physical qualities, the GIC powders have undergone extensive formulation and modification. This paper provides an overview of various fillers used to enhance the mechanical and physical properties of GICs.
Nursing Students’ Applications, Knowledge Needs, Self-Efficacy During COVID-19: A Descriptive Study
Authors: BURUCU Rukiye , DURMAZ Melike
Published: January 2023

Aim: Nursing students are also a health educator. During the COVID-19 process, nursing students both provided health education to individuals in need in their environment and implemented protective measures themselves. The aim of this study was to determine nursing students' self-efficacy, basic knowledge, and protective measures they applied during the COVID-19 outbreak.Method: This was a descriptive study. Ethics committee approval was obtained for the study. Data were collected interactively. The sample consisted of 672 voluntary nursing students 18 years of age from the universities in Turkey. Data were made using Statistical Package for Social Sciences (SPSS, v 21.0); Kruskal-Wallis and Mann Whitney-U tests, and Spearman’s correlation were used. "STROBE" checklist has been followed.Results: Gender had an effect on self-efficacy. Income level, place of residence, and self-efficacy had an effect on the number of in-house preventive measures. Regarding COVID-19 protection measures; girls, those living in rural areas and those with low income were found to be disadvantaged.Conclusion: Nursing students may need to be supported to feel competent. It may be recommended to educate disadvantaged groups as a priority in preventing the spread of the epidemic. In addition, nursing students can take part in the health education of the community. The findings of this study emphasize the importance of improving nursing education. Nursing students can guide society in public education.
Gender Differences in Students' Attitudes Towards Violence Against Women
Authors: ULAŞ KARAAHMETOĞLU Gülşen , ŞİMŞEK ÇETİNKAYA Şahika
Published: January 2023

Aim: This study was conducted as a descriptive study with the aim of determining the views and attitudes of university students about domestic violence against women.Method: The research was carried out between May and June 2018. The population of the research consisted of students studying at faculties and colleges within a university, and the sample consisted of 2453 students who agreed to participate in the study. The first part of the questionnaire, which was prepared by the researchers as a result of the literature review, consists of questions containing information about the introductory characteristics of the students; The second part consists of 34 questions about attitudes towards violence against women. Chi-square test was applied to examine the relationship between the variables.Results: Considering the results obtained from the findings, it was determined that there was a significant difference between the attitudes of female and male students towards economic, sexual, verbal, and physical violence against women (p<0,05). While women exhibited a more egalitarian attitude towards gender equality, male students displayed a traditional attitude. It was stated by 77,9% of the students that they did not experience violence from their families and 79,5% of them stated that they did not witness violence between their families.Conclusion: Knowing the attitudes of university students towards violence against women can contribute to the development of violence against women policies.
Comparison of Interpupillary Distance, Pupillary Diameter and Corneal Reflex Measured with Plusoptix A09 in Normally Developing Children and Autism
Authors: ŞAHBAZ İbrahim , TAŞDÖNDÜREN Emre , ÖZCAN Öznur Özge , ERGUZEL Turker , KARAHAN Mesut , KONUK Muhsin , TARHAN Nevzat
Published: January 2023

Aim: Autism Spectrum Disorder (ASD) is a developmental disorder that can present with an abnormality of the autonomic nervous system (ANS symptoms).Method: In this study, 38 eyes of 19 ASD were included with 19 healthy children (control group). Participants were analyzed according to their characteristics. Here, used the Plusoptix A09 devices to measure the difference in pupil size, corneal reflex, and interpupillary distance (IPD) between ASD and healthy children.Results: The mean age±standard deviation (SD) for the autism group was 4,6±2,5 years (range 2-11 years). In the group of normally developing children, the mean age was±SD 5,02±2,6 years (range 2-11 years). The size of the right pupil (p=0,006) and left pupil (p=0,007) was found to be significantly different in the control and experimental groups. IPD (p=0,000) was statistically significant between groups unlike the corneal reflex was not (p=0,173). The p-value is less than 0,05 in all statistical results.Conclusion: As a result, pupil diameter and IPD of children with autism were found to be larger than the control group, but there was no significant difference in corneal reflex. Pupillary measurements reveal differences between people with ASD.
Kan Plazmasında Satellit-2 Tekrar Elementi DNA Dizilerinin Karakterizasyonu
Authors: ÖZGÜR Emre , YILDIZ Anıl , BADEMLER Süleyman , GEZER Uğur
Published: January 2023

Amaç: Son yıllarda tıp biliminin farklı disiplinlerinde sıkça karşılaşılan kavramlardan biri olan “sıvı biyopsi”, hastaların tanı, prognoz analizi ve tedaviye cevabını değerlendirme gibi konularda girişimsel doku biyopsisi yerine, kan ve çeşitli vücut sıvılarındaki moleküler ve epigenetik biyobelirteçlerin kullanılmasını içerir. Dolaşımda serbest halde dolaşan DNA’da (‘cell-free DNA’, cfDNA) kanser hücrelerine özgü gen mutasyonlarının saptanması, kanser hücrelerinin içeriğinin vücut sıvılarına geçtiğinin kesin kanıtı olarak kabul edilmektedir. cfDNA’nın bileşiminin belirlenmesine yönelik dizileme çalışmaları, perisentrik satellit DNA dizilerinin, cfDNA’da genom oranlarına kıyasla daha fazla oranda temsil edildiğini bildirmiştir. Bu çalışmada, kanser açısından spesifik dizilerin saptanması amacıyla, Sat-2 dizilerinin polimeraz zincir reaksiyonunda (PCR) çoğaltılmaları sonrasında daha detaylı karakterizasyonu amaçlanmıştır.Yöntem: Çalışmada, sağlıklı ve metastatik meme kanserli hastaların plazmalarından 1. ve 10. kromozoma spesifik Sat-2 dizileri PCR ile çoğaltıldıktan sonra, otomatik elektroforez sisteminde ayrıştırıldılar.Bulgular: Yapılan büyüklük analizinde, iki bölgeden çok sayıda amplikon oluştuğu, bunların yaklaşık %50’ni sırasıyla 143 ve 115 bç uzunluğunda ürünlerin oluşturduğu belirlenmiştir. Bu iki PCR amplikonunun miktarı meme kanserli hastalarda daha yüksek olarak hesaplandı. Onuncu kromozoma özgü 115 bç’lik fargman dışındaki Sat-2 dizileri açısından kontroller ile hastalar arasında önemli farklar olduğu belirlenmiştir.Sonuç: Çalışma kapsamında elde edilen bulgular, Sat-2 tekrar elementine ait DNA dizilerinin sekanslanması sonrası kansere spesifik hedef bölgelerin saptanabileceğini ortaya koymaktadır.
Relationships of Mobile Phone Use with the Functions and Disabilities of Neck and Upper Extremity
Authors: GÜÇHAN TOPÇU Zehra , ANGIN Ender , DEPRELİ Ozde , YATAR İlker , MIHÇIOĞLU Serpil , TOMAÇ Hayriye
Published: January 2023

Aim: To determine the effects of mobile phone use on fine motor functions, neck, and upper limb disability values.Methods: Time duration of mobile phone use was recorded for a week. Rapid Upper Limb Assessment (RULA) was used to determine the risk level about posture while texting message on phones. Neck Disability Index (NDI) for neck pain and functional disability of neck on activities of daily life, Disabilities of the Arm, Shoulder, and Hand-Function/Symptom (DASH-FS) for the limitation in the functions of upper limb, Jebson Taylor Hand Function test for fine motor function.Results: Two hundred and seventy individuals (141 women, 129 men) whose mean ages were 21,48±1,86 years were included. While a significant correlation between duration of phone use and NDI score was specified (r=0,172; p=0,005), no significant correlation was found between duration of phone use and DASH-FS scores (r=0,092; p=0,130). It was found that there was a negative significant relationship between the duration of phone use and the total function score of the left hand and throwing small objects (p<0,01). According to RULA 95,6% of individuals have unacceptable phone usage postures, but no significant relationship was found between ergonomic risk level and NDI values, DASH-FS values, and hand functions (p>0,05).Conclusion: Although increased duration of phone use could cause neck problems, manual ability may be positively affected. In addition, since most participants have a poor posture while using a mobile phone, it is thought that this may be a risk factor for more musculoskeletal problems in older ages.
Del anecdotario matematia casos de éxito en el CECYTE Chiapas plantel 04 Jitotol
Authors: Pérez Susunaga Gamaliel
Published: January 2023

Se describe casos de éxito donde los estudiantes y docentes de (EMS) en el CECyTE Chiapas tuvimos que adaptarnos a la situación de emergencia sanitaria provocada por la COVID-19 en el contexto semi urbano de la región de los bosques, combinando recursos digitales y tradicionales, (uso del Anecdotario)herramienta que nos ayudó a entender al alumno como la pieza fundamental en este proceso educativo como sujeto y no meramente objeto ( NEM). El trabajar de manera escalonada en el laboratorio de cómputo y avanzar el programa de MatemaTIA , patrocinado por la UNICEF y promovido por la coordinación de CECyTES Nacional, programa es un sistema de inteligencia artificial, el cual permitió trazar la ruta de aprendizaje de cada alumno.
Role of echocardiography in acute pulmonary embolism
Authors: Oh Jin Kyung , Park Jae-Hyeong
Published: January 2023

Although pulmonary embolism (PE)-related mortality rate has decreased because of prompt diagnosis and effective therapy use, acute PE remains a potentially lethal disease. Due to its increasing prevalence, clinicians should pay attention to diagnosing and managing patients with acute PE. Echocardiography is the most commonly used method for diagnosing and managing acute PE; it also provides clues about hemodynamic instability in an emergency situation. It has been validated in the early risk stratification and impacts management strategies for treating acute PE. In hemodynamically unstable patients with acute PE, echocardiographic detection of right ventricular dysfunction is an indication for administering thrombolytics. In this review article, we discuss the role of echocardiography in the diagnosis and management of patients with acute PE.
Outcomes according to treatment modalities as a bridge to curative surgery for malignant obstruction of the proximal colon: stent versus stoma
Authors: Park Yong Eun , Hong Seung Min , Lee Seung Bum , Lee Hong Sub , Baek Dong Hoon , Cha Rari , Lee Jong Yoon , Kim Tae Oh , Lee Jong Hoon ,   Busan Ulsan Gyeongnam Intestinal Study Group Society (BIGS)
Published: January 2023

Background/Aims: The optimal treatment for acute malignant obstruction of the proximal colon (MOPC, proximal to the splenic flexure) remains challenging. Emergency resection, the traditional modality for MOPC, has shown significantly high mortality and morbidity rates, according to recent studies. This study aimed to investigate the clinical outcomes of stent vs stoma as a bridge to curative surgery for MOPC.Methods: This retrospective cohort study included 72 patients who underwent endoscopic placement of a self-expanding metallic stent (SEMS) or loop ileostomy for MOPC at six referral centers between January 2011 and July 2021. Clinical and pathological characteristics, procedure-related complications, and long-term mortality rates after curative surgery were analyzed.Results: During a mean follow-up period of 32 months, 30 patients (41.7%) underwent ileostomy preferentially for more proximal cancer, complete obstruction, and advanced tumor stage compared to the SEMS group. No difference was found in procedure-related complications, but five deaths were observed after ileostomy. Survival analysis for 5-year mortality after curative surgery showed no significant difference between the bridge modalities (log-rank p = 0.253).Conclusions: In this study, SEMS as a bridge to surgery showed relatively safe results in terms of post-procedural mortality. However, these results should be considered when performing ileostomy in patients with more advanced malignant obstruction.
Peritoneal Exudate Lymphocyte
Authors: Rosenstreich David L. , Rosenthal Alan S.
Published: January 2023

Guinea pig peritoneal exudate lymphocytes (PEL) are a population of highly antigen-reactive thymus-derived (T) lymphocytes that are relatively macrophage depleted (<1 to 2%). In the present study we have attempted to determine if these T lymphocytes, as a consequence of their extreme antigen sensitivity, could directly bind sufficient amounts of antigen (PPD) to become activated and thereby exhibit macrophage-independent proliferation in vitro. Using a functional assay of antigen binding we have determined that the antigen-binding ability of macrophages is so great that all of the antigen-binding in the PEL population can be accounted for by the few contaminating macrophages present in the population. Repeated passage of the PEL population over nylon-glass bead adherence columns results in a greater than 100-fold reduction in the number of residual macrophages. This degree of macrophage depletion is associated with a significant decrease in both the functional antigen-binding ability (86%) and the antigen-induced proliferative response (88%) of the highly purified PEL population. However, this loss of activity is due solely to the depletion of macrophages and not T lymphocytes, since the antigen-induced proliferation of the purified population can be restored with fresh macrophages and antigen. The data demonstrate the extreme difficulty of completely removing macrophages from a complex lymphoid population such as the PEL and ascribing with certainty and remaining function solely to its component lymphocytes rather than its macrophages. Furthermore, these studies argue against binding of functional amounts of PPD directly by T lymphocytes and suggest that antigen-binding by macrophages is an obligatory step in the activation of T lymphocytes in vitro.
Passive Hemagglutination Assay for Antibody to Subtypes of Hepatitis B Antigen
Authors: Gold Jon W. M. , Alter Harvey J. , Holland Paul V. , Gerin John L. , Purcell Robert H.
Published: January 2023

Antibody to the d and y subtypes of hepatitis B antigen (HB Ag) was detected by a modification of the passive hemagglutination assay (PHA) for anti-HB Ag. With this technique, anti-d or anti-y activity could be detected in many sera negative for anti-HB Ag by counterelectrophoresis but positive by PHA. The proportion of sera with detectable anti-subtype antibody increased as the PHA titer increased. Studies of blood donors from the United States and Egypt revealed frequencies of each anti-subtype antibody which closely paralleled the frequency of the same antigen subtype in each population. In all instances of antibody sero-conversion in which anti-subtype antibody could be detected, the antibody was directed against the same subtype as the antigen associated with infection or immunization. Antibodies against both subtypes of antigen were not detected in any patient, including those who had been repeatedly transfused.
Kinetic Studies of the Formation of the Properdin System Enzymes on Zymosan: Evidence That Nascent C3b Controls the Rate of Assembly
Authors: Nicholson Anne , Brade Volker , Lee Gerald D. , Shin Hyun S. , Mayer Manfred M.
Published: January 2023

On treatment of guinea pig serum with zymosan (Z) the properdin system becomes activated and combines with Z, yielding a complex ZX that comprises two multi-unit enzymes capable of cleaving complement components C3 and C5, respectively. One of the constitutents of both of these enzymes is complement fragment C3b. The present kinetic study deals with the role of this fragment in the assembly of ZX. As shown earlier, the formation of ZX is much slower in C4-deficient than in normal guinea pig serum. However, if Z coated with C3b (ZC3b) is used, instead of plain Z, the rate of formation of ZX in C4-deficient serum is as great as that in normal guinea pig serum. Hence, Z-bound C3b accelerates assembly of the properdin system enzymes, an observation which is compatible with the view that C3b serves to activate factor D of the properdin system. In addition, the possibility was raised that bound C3b may play a part in the properdin system beyond that of an activator for factor D.
Cellular Cooperation and Stimulatory Factors in Antibody Responses: Limiting Dilution Analysis in Vitro
Authors: Vann Douglas C. , Dotson Carroll Ray
Published: January 2023

Limiting dilution analyses with the Poisson model were performed on normal mouse spleen cells alone or in the presence of added cells or soluble factors. When a constant number of T cells activated to sheep red blood cells were added to cultures of diluted spleen cells the mean frequency of response to sheep red blood cells was 5- to 30-fold greater than that of spleen cells diluted alone. Adding a constant number of B cells did not produce a significant change in the mean frequency of response of diluted spleen cells. Since a responding unit is thought to be composed of T cells and B cells, these results indicate that antigen-specific T cells normally limit the generation of responding units when normal spleen cells are subjected to limiting dilution analysis alone. Conversely, B cells appear to be in relative excess.

Culture medium supernatants from mixed cultures of T cells activated to histocompatibility antigens and target cells bearing the antigens to which the T cells have been activated enhance antibody responses in vitro. When spleen cells were diluted in the presence of added supernatants the mean frequency of response was increased relative to that of spleen cells alone. This is interpreted to mean that the supernatants contain a factor, or factors which replace the requirement for T cells and enhance in vitro antibody responses by enabling more B cells to participate in the response.
A Functional Abnormality of the Fifth Component of Complement (C5) from Human Serum of Individuals with a Familial Opsonic Defect
Authors: Nilsson Ulf R. , Miller Michael E. , Wyman Susanne
Published: January 2023

The nature of a familial opsonic defect of human serum was explored. Studies of the unseparated deficient serum indicated a functional abnormality of C5 despite the presence of C5 in normal amounts. Studies of the isolated C5 from opsonically deficient serum revealed a restricted, primary, functional defect analogous to the one suggested by the studies of unseparated C5 in the deficient serum: absent opsonic but normal hemolytic function. In addition a secondary, functional defect occurred in isolated deficient C5 upon prolonged handling at 4°C: hemolytic as well as -generated chemotactic activity was lost. There was no indication of an inhibitor or inactivator of C5, nor of an abnormality of C activation at levels other than that of C5 in deficient serum. These functional studies therefore verify our previous interpretation that the yeast opsonic defect reflects a functional defect or dysfunction of C5. No structural correlate for the functional abnormality of C5 has as yet been demonstrated in studies with the Ouchterlony technique, various modifications of the polyacrylamide gel electrophoretic procedure, as well as sucrose density ultracentrifugation.
Immune Responses in Vitro
Authors: Pierce Carl W. , Kapp Judith A. , Wood David D. , Benacerraf Baruj
Published: January 2023

The function of macrophages in the development of primary plaque-forming cell responses in cultures of mouse splenic lymphoid cells has been investigated. Splenic and peritoneal exudate macrophages are equally efficient in supporting development of responses by splenic lymphoid cells. The active cell in the peritoneal exudate population is a phagocytic macrophage. Macrophages have at least two distinct functions. One is to promote the viability or survival of splenic lymphoid cells in culture; this function can be duplicated by the reducing agent 2-mercaptoethanol. The second function is antigen presentation.
Rabbit Secretory IgA: Identification and Genetic Control of Two Allotypes of Secretory Component
Authors: Knight Katherine L. , Rosenzweig Miriam , Lichter Edward A. , Hanly W. Carey
Published: January 2023

Two allotypes of rabbit secretory IgA have been identified with antisera obtained by cross-immunization of rabbits with secretory IgA. The two antisera, anti-t61 and anti-t62, each reacted by double diffusion analysis with secretory IgA from some but not all rabbits. Both anti-t61 and anti-t62 reacted with purified free secretory component obtained from whey. Thus, anti-t61 and anti-t62 are identifying allotypic specificities on secretory component.

Genetic studies revealed that t61 and t62 are controlled by allelic genes at an autosomal locus. The t locus is not closely linked to the VHa, Cαf and Cαg (heavy chain) loci nor to the b (light chain) locus of immunoglobulins.