bluuebunny/crossref_metadata_2025 huggingface dataset:
Toxicity Studies of DOX~DEX~Fe3O4@ZIF~ Peptides in Vitro and in Vivo
Authors: Wang Meiqi
Published: May 2023

Colorectal cancer is formed and developed through a multi-factor and multi-stage complex pathological process. The review provides an overview of the available colorectal cancer treatments and makes the case for the need to develop specific colon cancer therapeutic products that are safe and stable, with significant therapeutic efficacy and minimal patient sacrifice. The author reviews the progress made in the field of miRNA, nanomedicine system, epidermal growth factor receptor (EGFR), doxorubicin (DOX), dexmedetomidine (DEX) and peptides in the treatment of cancer and point out that more and more researchers are focusing on the treatment of cancer at the genetic level and on the combination of multiple approaches to treat cancer. This review provides an important theoretical reference for the development of multifunctional drugs for the multi-treatment targeting of colorectal cancer.
The Impact of Smoking on COVID-19
Authors: Cui Yiming
Published: May 2023

In 2019, the spread of a global pandemic was disturbing. Its name was COVID-19, the novel coronavirus. So far, more than 18 million patients have died. Although countries have established relatively mature response plans, the disaster is not completely over, and the era we are living in is called the post-pandemic era. Therefore, the study of COVID-19 is no longer limited to medical and biological research. It has penetrated our life. The problem we need to solve is not only how to cure it and protect it, but also more aspects of research. The same behavior that causes damage to the lungs is smoking, and the number of smokers worldwide is no longer small, for whom the act of smoking has become a normal part of life. So, the relationship between COVID-19 and smoking raises more important questions: does smoking affect the spread of COVID-19? Does smoking increase the risk of COVID-19? Does smoking affect treatment for COVID-19? The paper adopts the research method of literature review, summarizes the scientific literature of others, and involves knowledge of biology, statistics, and medicine. Finally, it is concluded that smoking exacerbates the spread of COVID-19, harms patients, and hinders treatment.
Effect of Human Activities on Natural Evolution
Authors: Lyu Wenxin
Published: May 2023

The knowledge of evolution and natural selection has brought people's understanding of nature a big step forward. This has also greatly improved human autonomy and control over nature. This is not a bad thing in itself, but it also changes the evolutionary laws of nature itself. When natural evolution occurs, the animal and its surrounding environment always gradually adapt to each other. Consequently, when humans speed up this process, it can also lead to surprises. In the analysis and study of these cases, a certain number of cases have had negative consequences, both for humans and the creature itself. In this article, the evolution and adaptation of the brown rat in New York City are introduced and studied in detail, and the data is actively used to provide evidence for the evolution of the brown rat in only a hundred and twenty years. The impact of brown rats on humans will also be manifested in various aspects of New York City's hygiene, disease, diet, and so on. In addition, this article makes a detailed analysis and investigation of the evolution of African elephant ivory. Comparisons are also made in detail in terms of the changes in the habits of African elephants.
Assess stimulation-induced dyskinesia and its potential physiological mechanism using phase-amplitude coupling
Authors: Gao Rui
Published: May 2023

With the increasing use of deep brain stimulation (DBS) on clinical treatment of Parkinsons diseases, stimulation-induced dyskinesia (SID) becomes more and more common. SID was often detected shortly after DBS treatment on patients. However, the pathogenesis of SID and exact region of SID remains unclear. The aim of this paper is to review the studies of stimulation-induced dyskinesia and try to propose a new method to study and quantify SID, which is phase-amplitude coupling. phase-amplitude coupling (PAC) has been widely used in many other studies of brain-related illness and therapies. It is believed to have a profound relationship with our brain activities. Because of the features of PAC itself, the anatomical regions related to SID after pallidal DBS in Parkinson's disease (PD) patients can be possibly found, and the value of PAC can be served as a biomarker for us to assess the stimulation-induced dyskinesia. However, further researches on patients should be done to verify this method. It is very important to understand how SID is formed and its pathogenesis because it may help us find the appropriate parameters of deep brain stimulation and reduce the damage caused by the implant of electrode
EMPIRICAL STUDY OF PROFIT MANAGEMENT WITH TAX MOTIVATION IN INDONESIA (CASE STUDY ON CONSUMER GOODS COMPANIES LISTED ON THE STOCK EXCHANGE)
Authors: Nisa Rahmatun , Muda Iskandar , Khaddafi Muammar
Published: May 2023

The destination of the study is to know and analyze the influence of management profit, profitability, leverage, firm size, ownership managerial, ownership institutions, and audit quality of tax avoidance simultaneously. The Population in this study is registered company in sector consumer goods companies on the Indonesia Stock Exchange (IDX) for the period 2016 – 2020. The Sample in this study was determined by using a purposive sampling technique.The type of data used is secondary data and testing the hypothesis used with STATA software. Test results hypothesis prove that many variables that are not taking a positive effect on avoidance tax. Such as variable management profit, size company, ownership managerial, and ownership institutional are negative. Variable profitability, leverage, and audit quality show the opposite result of this research is positive.
IDENTIFICATION OF Escherichia coli AND Salmonella sp. ON SOME PLANTATION PRODUCTS
Authors: Oktora Matondang Christina , Muklasin Muklasin , Nurhayati Nurhayati
Published: May 2023

Identification of Escherichia coli and Salmonella sp. In Several Plantation Products, the aim is to explain the results of the identification test of E. coli and Salmonella sp. on plantation products. The research was carried out with 4 treatments and 2 replications. Each replication consisted of 5 dilutions. The treatments used were cocoa powder, compost, water and lettuce in selective growing media (EMBA and SSA). The parameters observed were to see whether there were E. coli or Salmonella sp. that grew in the four samples, the number of colonies and color changes that occurred as well as gas or bubbles produced in the fermentation test of sugars (glucose, sucrose and lactose). Based on the test results, it was found that E. coli and Salmonella were not present in the cocoa powder samples in EMBA and SSA media. In the compost sample, the bacteria E. coli grew on EMBA media, but Salmonella bacteria did not grow on SSA media. Lettuce samples showed E. coli growing on EMBA media, while on SSA media there was E. coli and Salmonella bacteria. Meanwhile, in water samples, E. coli, Salmonella and other bacteria grew on EMBA media. And on SSA media, Salmonella and Shigella bacteria grow. In the fermentation test of sugars such as glucose, sucrose and lactose, the media changes color to yellow and there are gas/air bubbles. This shows that bacteria can ferment carbohydrates and can produce gas. Salmonella and other bacteria grow on EMBA media. And on SSA media, Salmonella and Shigella bacteria grow. In the fermentation test of sugars such as glucose, sucrose and lactose, the media changes color to yellow and there is gas/air bubbles. This shows that bacteria can ferment carbohydrates and can produce gas. Salmonella and other bacteria grow on EMBA media. And on SSA media, Salmonella and Shigella bacteria grow. In the fermentation test of sugars such as glucose, sucrose and lactose, the media changes color to yellow and there is gas/air bubbles. This shows that bacteria can ferment carbohydrates and can produce gas.
Analysis of Factors Affecting Work Productivity of Tea Pickers at the Tea and Quinine Research Center, Simalungun Regency
Authors: Sagutray Simangunsong Roki
Published: May 2023

This study aims to determine the effect of age, work experience, and gender on the work productivity of tea pickers. This research was conducted in the PPTK Laut Tawar Gardens, Simalungun Regency. The sampling technique used is probability sampling technique with a sample size of 40 respondents. To determine the factors that influence the work productivity of tea pickers at the Tea and Quinine Research Center, Simalungun Regency, statistical analysis was used with the classical assumption test method, multiple linear, and hypothesis testing. Data processing using SPSS computer software. The results of this study indicate that all independent variables, namely age (X1), work experience (X2) and gender (D1) simultaneously, have a significant effect on the dependent variable, namely work productivity (Y).
Working Capital Management Relationship to Profitability of Plastic and Packaging Sub-Sector Companies on the Indonesia Stock Exchange
Authors: Rachyu purbowati
Published: May 2023

The purpose of this study isto determine the influence of working capital management consisting of variables Cash Turnover, Inventory Turnover, Working Capital Turnover affecting profitability in Plastic and Packaging Sub-Sector companies listed on the IDX.  The research approach uses quantitative descriptive methods. The population that will be used is the financial report data of plastic and packaging sub-sector companies listed on the Indonesia Stock Exchange with the purposive sampling sampling method with the criteria of plastic and packaging sub-sector companies listed on the Indonesia Stock Exchange which have complete financial statements in the period 2011 - 2020 so that the data used are 60 financial statement data. Data analysis uses multiple linear regression. The results showed that thereis a significant positive influence of cash turnover on profitability, meaning that the higher the cash turnover, the higher the profitability, thehigher the cash turnover will be better because this means that the higher the efficiency of cash use and the greater the profit obtained.  There is a significant positive effect of inventory turnover on profitability, meaning that the higher the inventory turnover, the higher the profitability, the higher the inventory turnover, the higher the profit obtained.  There is no effect of capital turnover on profitability, which means that the rise and fall of capital turnover does not affect the rise and fall of profitability.
PROCESSING OF FLY ASH & BOTTOM ASH IN THE MANUFACTURING OF PAVING BLOCKS TO REDUCE THE TOTAL POLLUTION OF NON-B3 WASTE AT PLTU NAGAN RAYA
Authors: Ari Ami Rida , Sriwahyuni Susy
Published: May 2023

Industrial waste remains a problem in today's industrial era. The rapid development of industry has led to an increase in solid, liquid and gaseous wastes. Fly ash and bottom ash (FABA) are solid wastes from coal combustion. In this study, the authors wanted to know how to utilize fly ash and bottom ash solid waste in the manufacture of paving blocks in order to reduce non-B3 waste pollution by combining cement as the adhesive material. This research is descriptive with a qualitative approach, the data collection method is obtained through direct interviews with environmental operators who are responsible for the manufacture of paving blocks, and the data is taken from the PLTU Nagan Raya document. The results showed that the operational activities of PLTU Nagan Raya produce 60-70 tons of fly ash and 8-10 tons of bottom ash per day in the form of solid waste in one operating unit. Temporary Storage Area (TPS) Fly ash and bottom ash are coated with High-Density Polyethylene (HDPE), and Geonet. The results of the research suggest that the use of fly ash and bottom ash should not only be used in the manufacture of paving blocks and internal materials, but also in the manufacture of other external building materials, so as to reduce the amount of non-B3 waste at PLTU Nagan Raya.
ANALYSIS OF TREATMENT COMPLIANCE WITH TUBERCULOSIS (TB) PATIENTS IN TB MANAGEMENT PROGRAM IN JOHAN PAHLAWAN PUSKESMAS, ACEH BARAT REGENCY
Authors: Nafitri SA Desi , Safrizal Safrizal
Published: May 2023

Tuberculosis is a chronic infectious disease caused by the bacterium Mycobacterium tuberculosis. Johan Pahlawan Puskesmas is the Puskesmas with the most TB cases compared to other Puskesmas based on the results of TB data reports from the West Aceh Health Office. There were 35 patients being treated based on 314 suspected cases reported from the Johan Pahlawan Health Center. The type of research used in this research is descriptive qualitative . In this study, the selection of informants was carried out using a purposive sampling method with a total of 5 informants. The data collection method in this research is by conducting in- depth interviews . The results of the study were determined based on several categories which were summarized from the results of in-depth interviews, some of these categories were formed into four themes, namely duration of TB treatment, knowledge about TB, presence of drug-taking supervisors and barriers to treatment. Researchers suggest to the health service unit to form a team of extension workers in providing education to the public, to health workers to be more proactive in monitoring the role of the Drug Swallowing Supervisor and patient regularity, and making agreements with patients to complete treatment.
STRATEGY IN MANAGING STUNTING THROUGH MONITORING OF CONSUMPTION PATTERNS OF PREGNANT WOMEN IN GAMPONG TEUPIN PANAH, KAWAY XVI DISTRICT, WEST ACEH
Authors: Amelia Noni , Nih Farisni Tengku
Published: May 2023

Stunting is a nutritionary disputed point accompanying to the aggrandizement and exploitation of toddlers. The determination of this contemplate is to supply a resolution for the agreement in tackling stunting nailed down monitoring the consumption archetypes of heavy with child women in Teupin Panah Village, Kaway XVI District. This evaluation was conducted victimisationing descriptive qualitative evaluation in marchland 2022 at the Posyandu Gampong Teupin Arrow, Kaway XVI District, westbound Aceh Regency. fountain-heads of collections in this contemplate victimisationing influential collections and less important collections with the character of heavy with child women as severals as 10 people. The consequences of press conference conducted in Teupin Panah Village, Kaway XVI District, explicit that thither were all the more heavy with child women in the community who did not distinguish the grandness of consumption archetypes during pregnancy, As it is recognized that consumption life-giving chop chop during gestation conspicuously lay hold of the aggrandizement and exploitation of the descendant in the womb. The determination is that a heavy with child womanhood be in want of to remuneration consideration to the aspiration of nutrients that participate her dead end for that it grips a diversification of nutritionary aspiration to accommodate the nutrients contained in the chop chop exhausted by heavy with child women.
FACTORS FACTORS THAT INFLUENCE THE NUTRITIONAL STATUS OF CHILDREN TO FOOD SECURITY IN TEUPIN PANAH VILLAGE, KAWAY XVI DISTRICT, WEST ACEH REGENCY
Authors: Ihda. AF Nuria , Nih Farisni Tengku
Published: May 2023

nutritionary be in want of for children at the commencement of get-up-and-go is a extremely far-reaching configuration that be required to be considered. Malnutrition buoy come across deficient predicaments that are inevitable, where the bottom predicaments buoy consideration interruption of the brain's working processes and buoy furthermore cutting edge to death. The determination of this contemplate was to treasure trove the constituents that consequence the nutritionary prominence of children underneath five-spot on chop chop safe keeping in Teupin Panah Village, Kaway XVI District, westbound Aceh Regency. This evaluation disposition put into practice decimal evaluation with representatives therein glance at videlicet formal progenitrix who chalk up toddlers as severals as 30 samples. The collections obtained in the configuration of influential collections and less important data. influential collections are the consequences of the press conference cognitive semantics victimisationing questionnaires and chop chop commemoration implements for 24 hours, patch the less important collections in the configuration of posyandu collections and community occupation collections application univariate analysis, videlicet the chi-square test. The consequences showed that 18 of the 30 respondents had employments with chop chop safe keeping status, the consequences of the Chi straightforward evaluation got p = 0. 055 (p = <0. 05) which was understood as having a substantial communication or consequence between elbow grease and chop chop security. the determination that the factor that buoy influence the nutritionary prominence of children underneath five-spot on chop chop safe keeping is the elbow grease of parents, where a first-class employment testament predispose a first-class resource so that chop chop availableness is fulfilled. The consummation of first-class nutrition is backed by an correspondent commensurate of income. kith and kin resource or economical prominence is individual of the constituents related the consummation of chop chop availableness in the kith and kin
DISASTER PREPAREDNESS TOWARDS COMMUNITIES’ ANXIETY (A LANDSLIDE CASE STUDY IN LAMKLENG VILLAGE, ACEH BESAR)
Authors: Miska Rahmah  , M. Dirhamsyah  , Marty Mawarpury
Published: May 2023

The impacts of landslide are loss of life, people and livestock get injury, infrastructure, agricultural land, housing damage, economic loss, and anxiety experienced. Anxiety will have negative impacts, such as panic and respiratory disorders. This study aimed to analyze the correlation between disaster preparedness and anxiety, the effect of disaster preparedness on anxiety, the level of community disaster preparedness, and the level of community anxiety. This study used a correlational quantitative research design. A questionnaire of Google forms was used as a data collection technique. LIPI-UNESCO/ISDR was a parameter scale for preparedness variables, and HARS (Hamilton Anxiety Rating Scale) for anxiety variables. The total number of respondents was 74, and a random sampling technique and Slovin's formula were used to select the sample for this study. Data sources are secondary data and primary data. Descriptive statistics, univariate analysis, and Pearson product-moment were used for analyzing the data. The disaster preparedness in Lamkleng was in the almost ready category with an index of 63, and the community's anxiety level was 85.1% and in the serious category, and there was a relationship between disaster preparedness and anxiety.
THE IMPACT THAT SOCIAL MEDIA HAS HAD ON TODAY'S GENERATION OF INDIAN YOUTH: AN ANALYTICAL STUDY
Authors: AHMAD DAR SHOWKAT , NAGRATH DOLLY
Published: May 2023

Social media has become a daily habit in most people’s lives. People of all ages participate in social media, and the average Indian devotes nearly 2.4 hours per day to this one activity alone. People are able to voice their concerns and share their perspectives through the medium of social media. When it comes to understanding social media, people must first be comfortable with the notion. Users can communicate with one another and share information, thoughts, opinions, images, and videos via Internet-based programmes known as "social media.. In order to access content, share content with other users of that social media platform, and converse with other users of that social media platform, an individual must first sign up for an account and then sign in to that account. Facebook, Twitter, WhatsApp, Snap Chat, Telegram, and LinkedIn are just a few of the most prominent and frequently used social networking platforms today; others include Snap chat etc. It's noteworthy to observe that most of these social networking sites have a disproportionately high proportion of teen users. In India, adolescents and teenagers between the ages of 13 and 19 make up 31 percent of the overall number of people who use social media (Statista, 2021). Users in India between the ages of 18 and 24 make up the majority of Facebook and Instagram users in the country. We take a descriptive and analytical stance when discussing social media and its effects on young people, both good and bad, in this study. We heavily rely on the thematic analysis tool MAXQDA to draw a conclusion. We discuss all facets of social media, including both positive and bad effects. Specific areas including business, education, society, and young people are highlighted.
Vitiligo after treatment with Pembrolizumab in a patient with metastatic bronchopulmonary adenocarcinoma : a case report with review of the literature.
Authors: chebli Najwa , Dahiri Mustapha , Aamraoui Meryem , Ghissassi Ibrahim , Mrabti Hind , Boutayeb Saber , Errihani Hassan
Published: May 2023

Vitiligo has been reported in 2% to 8.3% of patients followed for melanoma. Other studies have reported the rarity of this event, especially in patients followed for other metastatic cancers.
We report a rare case of vitiligo which occurred in a 67-year-old patient followed for metastatic bronchopulmonary cancer treated with immunotherapy such as Pembrolizumab.
Vitiligo occurring with the use of pembrolizumab in bronchopulmonary cancer has been exceptionally reported in the literature.
Immunotherapy in bronchopulmonary cancer is associated with many side effects, vitiligo is very rare in this context and can have an impact on the quality of life of patients.
Unusual presentations of Salmonella infections- A case series
Authors: Babu Aishwarya , Thakar Vrushali , Sawant Shailaja , Jadhavar Sulochana , Modak Meera
Published: May 2023

Introduction
Salmonella predominantly causes gastroenteritis but it can cause many other serious infections ranging from osteomyelitis to infective endocarditis and meningitis. These infections are not explored much even in a typhoid endemic country like India.
Case Series
We have described six uncommon cases of Salmonellosis obtained from clinical specimens processed in our laboratory (from December 2021- September 2022) like urine, pus, tissue and aspirate (excluding blood and stool). We obtained two isolates of Salmonella Enterica, two isolates of Salmonella Paratyphi B, one isolate of Salmonella Typhi and one isolate of Salmonella species which we were unable to speciate. Sending the proper sample for culture will help in coming to the right diagnosis which will result in prompt treatment thus improving the clinical status of the patient.
Conclusion
We should be vigilant about the possibility of Salmonella causing infections other than enteric fever especially in patients who have chronic diseases or are immunocompromised so that timely treatment with right antimicrobials can be given.
Perspective: The Role of Cryopreservation Techniques in Manufacturing, Transport, and Storage of Car-T Therapy Products
Authors: Jandová Miroslava , Stacey Glyn Nigel , Lánská Miriam , Gregor Jií , Rozsívalová Petra , Beková Lenka , Woidigová Ducháová Zuzana , Belada David , Radocha Jakub , Měřička Pavel , Fuller Barry
Published: May 2023

Several clinical trials have proved the efficacy and safety of T-cells chimeric antigen receptor (CAR-T cells) in treatment of malignant lymphoma and the first products were registered in the European Union in 2018. The shelf-life of CAR-T cell products in the liquid state is short,
so cryopreservation offers a significant benefit for logistics in manufacturing and patient management. Direct shipment of the cryopreserved CAR-T cell therapy products to the clinical department is feasible, nevertheless, intermediate storage in the hospital cryostorage facility gives significant
advantage in planning of their administration to patients. Moreover, some manufacturers prefer transport of the starting material cryopreserved at the collection site. The cryopreservation protocol used for starting material by the authors is based on combining dimethyl sulphoxide (DMSO) with
hydroxyethyl starch (HES) and slow controlled cooling in cryobags housed in metal cassettes. This achieves the mononuclear cell post-thaw viability of 98.8 ± 0.5 % and recovery of 72.8, ± 10.2 %. Transport of the starting material to the manufactures and return
transport of the CAR-T therapy product is performed by authorized courier companies. Intermediate cryostorage of the final CAR-T cell therapy product is performed in a separate dry-storage liquid nitrogen container. On the day of infusion, the cryopreserved products are transported to the
clinical department in a dry shipper. On the wards the product is removed from the cassette, inserted into a sterile plastic bag, thawed in a 37 °C water bath followed by immediate intravenous administration. The authors discuss the adherence of the used technology to good manufacturing
practice (GMP) principles and genetic safety assurance rules.
Assessing the Benefits of Antioxidant and Antibiotics Treatments for Cryopreservation of the Model AlgaEctocarpus Siliculosusand the Endemic AlgaAcinetospora Asiatica
Authors: Avila-Peltroche Jose , Yeon Won Boo , Oh Cho Tae
Published: May 2023

BACKGROUND:Cryopreservation in liquid nitrogen is a suitable technique for preserving seaweeds, a group of photosynthetic organisms with many applications. Although there are some standard protocols for seaweed cryopreservation, most rely on expensive controlled-rate coolers. Moreover, several factors, such as the use of antioxidants or antibiotics, remain unexplored.OBJECTIVE:To test the effect of 2-mercapthoethanol (antioxidant) and antibiotic mixtures on the cryopreservation of the model alga Ectocarpus siliculosus and the endemic brown seaweed Acinetospora asiatica using a low-tech passive rate cooler.MATERIALS AND METHODS:2mercaptoethanol was added to the cryoprotectant (CPA) solution, while antibiotic mixtures were included in the culture medium during the recovery process. In addition, two CPA solutions were tested on E. siliculosus.RESULTS:After two weeks of recovery, the treatment comprising PSC antibiotic mixture (Penicillin G, streptomycin, and chloramphenicol) showed a significant increase in post-thaw viability. Antioxidant treatment did not improve viability. The highest viabilities for E. siliculosus and A. asiatica were 64-83%, and 83-87%, respectively, using 10% glycerol + 10% proline as CPA solution.CONCLUSION:E. siliculosus and A. asiatica were successfully cryopreserved using a low-tech passive rate cooler, 10% glycerol + 10% proline solution, and antibiotic treatment. The highest post-thaw viabilities (64-87%) reported for PSC antibiotic mixture suggest the potential benefits of using antibiotics during post-thaw recovery of marine macroalgae. This study is the first report on the cryopreservation of A. asiatica.
Effect of Cryoprotectant and Pre-Freezing on the Sperm Motility, Viability and Fertility of Goldfish Carassius Auratus (Pisces: Cyprinidae) Post Short-Term Cryopreservation
Authors: Nurlaili Nurlaili , Eriani Kartini , Salma Itsnatani , Maulida Siti , Riska Rahayu Sri , Syafrida Handayani Luvi , Kocabas Filiz Kutluyer , Siti-Azizah Mohd Nor , Wilkes Martin , Muchlisin Zainal Abidin
Published: May 2023

BACKGRUND: Goldfish Carassius auratus is a popular ornamental fish extensively cultured worldwide. Sperm cryopreservation is a common fish breeding method that ensures sperm availability around the year. Studies on cryopreservation of goldfish sperm, especially on the
suitability of cryoprotectant types and pre-freezing time, are scarcely available. OBJECTIVE: To determine the most suitable type of cryoprotectant and pre-freezing for the successful cryopreservation of goldfish sperm. MATERIALS AND METHODS: A completely randomized design with
two factors was utilized in this study. The first factor is the type of cryoprotectants, which included methanol, ethanol, ethylene glycol, glycerol, and DMSO. The second is pre-freezing times of 10, 20, 30, and 40 min at each of the pre- freezing temperatures of 4°C, −10°C,
and −79°C, meaning that the total times for the ramping down of temperature were 30, 60, 90 and 120 min, respectively. The Ringer solution and 10% egg yolk were used as extender and extracellular cryoprotectant. The sperm was stored at −179°C for 7 days. RESULTS:
The ANOVA test showed that cryoprotectants and pre-freezing significantly affected the motility, viability, and fertility of goldfish sperm after freezing in liquid nitrogen for 7 days (ρ<0.05). Furthermore, 10% DMSO combined with 15% egg yolk with an pre-freezing time
of 20 min can maintain sperm motility, viability, and fertility higher than other treatments, by 79%, 80%, and 33%, respectively. The agarose gel electrophoresis showed no DNA fragmentation in all samples, including fresh sperm. CONCLUSION: We conclude that 10%
DMSO combined with 15% egg yolk and 20 min pre-freezing is the best treatment for goldfish sperm cryopreservation.
Assessments of energy, macro and micronutrient intakes in children and adolescents with type 1 diabetes mellitus
Authors: OZKAYA Volkan , OZGEN OZKAYA Sebnem
Published: May 2023

Objective: This study aims at examining dietary intake in children and adolescents with type 1 diabetes mellitus (DM) and comparing

the results with national dietary intake recommendations.

Patients and Methods: One hundred fifty children and adolescents (52.7% female) with an average age of 12.2±3.1 years and with

type 1 DM who were followed by the Pediatric Endocrinology Polyclinic participated in the study. Three-day food intake records and

clinical information regarding the type 1 DM condition of the participants were obtained.

Results: No gender-related significant difference was found among the participants regarding food intake. The percentage of energy

derived from fat (average 39.6%) and saturated fat (16.1%) were higher than the recommended levels in both gender groups. The

percentage of energy derived from carbohydrates (female 44.1±5.7%, male 43.0±6.8%) was below the recommended levels. The dietary

fiber intake in children aged 6-10 years with type 1 DM met recommendations, whereas, it was below the recommended levels in other

age groups. Micronutrient inadequacy was common in children and adolescents with type 1 DM.

Conclusions: The authors believe that guidelines and programs are needed for children and adolescents with type 1 DM to reduce

total fat and saturated fat intake, increase carbohydrate and dietary fiber intake up to the recommended levels, and prevent multiple

micronutrient inadequacies.
READINESS OF A NEW UKRAINIAN SCHOOL TEACHER FOR INNOVATIVE ACTIVITIES
Authors: LAVROVA Larisa , SAVCHENKO Viktoriya
Published: May 2023

The article analyzes the problem of the readiness of NUS teachers to carry out innovative activities in the process of implementing educational reforms. It is shown that it is the NUS teacher who acts as an agent of changes, as he is the subject of the direct implementation of the guidelines of educational reforms in the pedagogical process. The readiness of NUS teachers for the systematic use and development of innovative pedagogical technologies, that is, for innovative activities at the practical-operational, technological level of the implementation of educational reform tasks, deserves special attention. The readiness of the NUS teacher for innovative activities in general and the application of innovative pedagogical technologies in particular, which is formed at the intersection of the development of the teacher's potential to maximize his creative and professional resource and his own resource of self-actualization as an individual, is considered. It is proven that innovative pedagogical technologies should be considered precisely as an integrated mechanism of simultaneous transformation of the educational process and teachers in the system of the National Academy of Sciences which combines the subject and object subsystems of the innovation process. It is argued that training within the framework of the project of training of teachers of NUS in innovative pedagogical technologies should be considered at the same time as the introduction of innovative approaches to postgraduate pedagogical education, which contribute to the professional development of teachers and educational managers. In particular, for NUS teachers, the technology of developmental learning allows them to effectively prepare for the implementation of several basic directions of innovations of NUS. The technology of gamification and in general the technology of edutainment, i.e. education through entertainment and games, is also promising for the preparation of teachers of the National University for the introduction of innovations in the educational process. Attention should be paid to the pedagogy of partnership, which is approved in the Concept of the National Academy of Sciences as the basic mechanism for the formation of an innovative educational environment.
DISTANCE LEARNING FOR UKRAINIAN SCHOOLCHILDREN UNDER THE CONDITIONS OF MARTIAL LAW: ORGANIZATIONAL ASPECT
Authors: DUDNIK Volodymyr , TUKHTAROVA Tetіana , KUCHER Rostуslav
Published: May 2023

The article reveals the features of the organization of distance education in secondary school of Ukraine under the martial law conditions. The essence of the problem faced by the education system is presented, including the inability to provide full-time learning process due to the destruction of educational institutions and safety threats to the schoolchildren. The authors justify the thesis that distance education in Ukraine has nowadays changed its status from a possible option to the priority mode of the educational process organization. The presentation of the research material is based on the following points: analysis of the current legal framework for the implementation of distance education in schools; the analysis of the most common supportive tools, distance learning resources, platforms for methodical support of educators, and practical recommendations on the distance learning organization. The authors carry out the analysis of the already existing and functional projects designed to provide methodical support to Ukrainian educators, detailing the features of the functioning of the "All-Ukrainian Online School", "All-Ukrainian Schedule", the essence of the "Quality of Education" project, etc. It is concluded that the Ukrainian government is working on various organizational aspects of the distance learning implementation paying attention to the importance of restructuring the calendar and thematic planning of education process, the need to organize distance learning in an educational institution within a single educational platform, the peculiarities of knowledge acquisition in synchronous/asynchronous modes of teaching. Selected organizational issues relate to clarifying the psychological conditions of knowledge acquisition in the distance learning format, and the importance of establishing communication with parents. In today's conditions, Ukrainian distance learning provides various supportive online tools for both educators and students. However, along with this, there are issues that await their further resolution, in particular: the technical aspect of the organization of distance learning under the conditions of martial law; the need to increase the digital competencies of all participants in the educational process; and the importance of providing methodological assistance to teachers regarding their work in a distance format.
ENTELEKTÜEL SERMAYE BİLEŞENLERİNİN FİRMA PERFORMANSINA ETKİSİ: BORSA İSTANBUL’DA İŞLEM GÖREN TEKNOLOJİ FİRMALARI ÜZERİNE BİR UYGULAMA
Authors: KARAÖMER Yunus , KAKİLLİ ACARAVCI Songül , TELEK Ali
Published: May 2023

Günümüzde firmaların entelektüel sermaye bileşenlerinin sahip oldukları fiziksel varlıkları kadar önem kazandığı görülmektedir. Bu nedenle, bilgi temelli varlıkların, firmanın verimliliği açısından önemi göz ardı edilmemelidir. Bu çalışmanın amacı, entelektüel sermaye bileşenlerinin BİST’de işlem gören teknoloji firmalarının performansı üzerine etkisini incelemektir. Çalışmada, Pulic’in (1998) geliştirdiği, entelektüel katma değer bileşenleri ile firma performans ölçütleri arasındaki ilişkiler panel veri yöntemi kullanılarak analiz edilmiştir. Elde edilen bulgulara göre, entelektüel sermaye bileşenlerinin teknoloji firmalarının performansını olumlu yönde etkilediği tespit edilmiştir. Bu bulgu teknoloji sektöründe faaliyet gösteren firmaların performanslarında fiziki ve finansal varlıkların önemli bir yere sahip olduğunu göstermektedir. Buna göre teknoloji sektöründeki firmaların değer yaratma ve iyileştirme süreçlerinde fiziki ve finansal sermaye yatırımlarına önem vermeleri gerektiği söylenebilir. Ayrıca, mevcut fiziksel ve finansal sermayelerini en etkin şekilde kullanarak yüksek katma değerli getiriler elde edebilirler ve bu sayede performanslarını artırabilirler. Bu çalışmanın bulguları, teknoloji firmalarının entelektüel sermayelerinin doğru yönetimi ile firma performanslarına önemli ölçüde katkıda bulunabileceği konusunda yol gösterici niteliğe sahiptir. Ayrıca, çalışmanın bulguları sadece teknoloji firmaları için değil, aynı zamanda bu firmaların paydaşları için de önemli bir bilgi kaynağıdır.
KATILIMCI BÜTÇELEME ARACI OLARAK VATANDAŞ BÜTÇESİ VE TÜRKİYE UYGULAMASI
Authors: GEYİK Osman , ÖZBAY Filiz
Published: May 2023

Mali politikalarda ve kamu mali yönetimi anlayışında yaşanan güncel gelişmelerin ardından bütçeleme süreci gibi birçok alanda vatandaşların süreçlere daha fazla dâhil olması söz konusu olmuştur. Vatandaşların özellikle ödemiş oldukları vergilerin nerelerde kullanıldığı konusunda fikir sahibi olma isteklerinin artması ve bu sayede kamu politikalarının etkin bir şekilde uygulanıp uygulanmadığı; ayrıca kaynaklarının yerinde kullanılıp kullanılmadığı konusunda daha fazla bilgi edinme ve bu durumları sorgulama ihtiyaçları hükümetleri bu süreçte daha fazla şeffaf davranmaya zorlamıştır. Özellikle seçmen davranışları gereği oy verme kararlarının şekillenmesinde önemli bir yere sahip olan vaatlerin kamu harcamaları yoluyla gerçekleştirilecek olması, bütçeleme süreçlerinin şeffaf bir şekilde sürdürülmesini gerekli kılmaktadır. 5018 sayılı Kamu Mali Yönetimi ve Kontrol Kanunu ile bütçeleme anlayışında yapılan yenilikler de bu amaca hizmet edecek şekilde dizayn edilmiş ve yeni anlayış hayata geçirilmiştir. Bütçeleme süreçlerinin şeffaf bir şekilde sürdürülmesini sağlamak amacıyla uygulanan vatandaş bütçesi, vatandaşların bütçe sürecinde aktif katılımı artırarak halkın bilgi edinmesini kolaylaştırmış ve katılımcı bütçelemenin bir aracı olarak görülmüştür. Bu kapsamda çalışmada öncelikle vatandaş bütçenin kavramsal çerçevesi ele alınmış, devamında ise Türkiye uygulamasına yer verilerek konu değerlendirilmiştir.
ANALISIS KINERJA PEGAWAI BERDASARKAN DISIPLIN KERJA, MOTIVASI, KOMPENSASI DAN GAYA KEPEMIMPINAN PADA RUMAH SAKIT UMUM DAERAH DATU BERU TAKENGON
Authors: Abqa Rizkan , Azhari Azhari
Published: May 2023

The purpose of this study is to prove and analyze the Influence of work discipline, work motivation, compensation and leadership style on the performance of the employees of RSUD Datu Beru Takengon. The study was conducted on a sample of 213 employees with data collection through questionnaires and data analysis with a quantitative approach based on path analysis. The results showed that; a) there is a significant positive effect of employee discipline on their performance of 9.14%, b) there is a positive influence of work motivation on employee performance of 8.75%, c) there is a positive influence of compensation factors on employee performance that is 9.10 %, and d) there is a significant effect of leadership style variable on employee performance by 8.45%, and e) there is a simultaneous effect of work discipline, work motivation, compensation and leadership style on employee performance at Datu Beru Takengon Central Aceh Hospital of 35.7 %.
ANTIMICROBIAL, ANTIOXIDANT, GC-MS ANALYSIS AND MOLECULAR DOCKING ANALYSIS OF BIOACTIVE COMPOUNDS OF ENDOPHYTE ASPERGILLUS FLAVUS FROM ARGEMONE MEXICANA
Authors: Singh Pooja , Sharma Angkita , Bordoloi Manobjyoti , Paul Nandi Shoma
Published: May 2023

Studies of potent antibiotics from plant endophytes have become a new interest among researchers. Plant derived antibiotics are costly, laborious, time-consuming and require extensive area of land. Endophytes can be used as an alternative source of antibiotics. Endophytes are microbes (bacteria and fungi) that live inside healthy plant tissues and do not show any antagonistic symptoms. They produce a variety of secondary metabolites having various commercial properties, medicinal, environmental, and agronomic purposes. In present work, endophytic fungi Aspergillus flavus associated with Argemone mexicana, was tested for its antimicrobial activity. The secondary metabolites of A. flavus were extracted using ethyl acetate solvent and tested for their antibacterial potential against certain Gram-negative bacteria, Salmonella typhimurium, Klebsiella pneumoniae, Vibrio cholerae, Escherichia coli, and Gram-positive bacteria Staphylococcus aureus using Agar well diffusion assay. Thin layer chromatographic bands were also checked further to know the bioactive spot. Gas chromatography- mass spectroscopy (GC-MS) was used to identify the bioactive compounds in TLC fraction and eighteen bioactive compounds were identified. Molecular docking and MM-GBSA were performed for the bioactive compounds with the respective proteins of the S. aureus (5JG0, 5JQ6, 1T2W, 3WYI, 3TFP, 3G7B, and 3WQU) and E. coli (1AJ0, 1GG4, 1 AJ6, 5ZHE and 7D6G) by using Schrodinger Maestro. In silico analysis suggested that Methyl (3-oxo-2-pentylcyclopentyl) acetate (MOPA) and 13-Hexyloxacyclotridec-10-en-2-one (HCT) exhibited the best binding affinity with most of the receptors. Pharmacokinetics and physicochemical analysis also showed that HCT and MOPA are the best drug candidate for the S. aureus and E. coli.
The Positive Effect of Cultural Knowledge on Listening Comprehension of EFL Learners
Authors: Sun Zhaochun , Tan Aiqing
Published: May 2023

The objective of this study was to investigate the effect of target cultural knowledge on the listening comprehension proficiency of Chinese EFL learners. Two groups of intermediate-level English language learners participated in the study. One group received English lessons on reading, writing, listening, and speaking, as well as a curriculum focused on target cultural knowledge, specifically the culture of Britain and the US. The other group received only English lessons on reading, writing, listening, and speaking, without any focus on target cultural knowledge. The comparison between the results of a pre-test and a post-test administered to both groups indicated that target cultural knowledge had a positive impact on the listening competence of EFL learners. This finding was also confirmed by interviews with the EFL learners. The study is significant for the teaching of English listening comprehension. Furthermore, the findings also have important implications for the teaching of reading and writing.
Development and Validation of a Short-Form Inventory to Identify Personality Types: The Personality Identity Estimator (PIE)
Authors: Conti Gary J.
Published: May 2023

The use of personality inventories has been limited because of their cost and the length. To overcome these limitations, this study created the Personality Identity Estimator (PIE), an easy-to-use inventory to estimate personality types that can be used at no cost. PIE is a categorical inventory containing 12 items with 3 items for each of the 4 personality-type dimensions in Jungian theory. A sample of 1,104 was used to create PIE. Validity was established through multivariate analyses using data from the administration of the Myers-Briggs Type Indicator to 553 of the sample. Reliability was established by test-retest. Consequently, PIE is a new short-form instrument to estimate personality type following Jung’s concept of personality types. PIE can be completed quickly, is easy to score and interpret, and can be used for self-assessment of personality types. PIE can be used to address individual differences, to increase self-awareness, and as an interactive instructional tool. Thus, PIE is a new valid and reliable tool that can be used in both instructional and research settings confidently and at no charge. Permission is granted to use the Personality Identity Estimator in practice and research. A printable copy of PIE is appended.
Critical Friend Groups: The Unexpected Relationships Among Education Majors During Study Abroad
Authors: Jones Meredith K. , McNulty Carol P.
Published: May 2023

Critical friendship is an innovative method used to strengthen an individual’s professional skills, including critical reflection, thinking, and problem-solving abilities in educational settings. Critical friendships can occur through one-on-one relationships or in groups known as critical friendship groups (CFGs). Literature on CFGs examines the benefits of structured CFGs integrated into teacher preparation programs. CFGs that form beyond university walls, like a study abroad context, have not been discussed in the literature even though these experiences can be the catalyst for CFGs. This case study illustrates how a CFG was formed during a study abroad trip to Belize with undergraduate and graduate education students that resulted in five major findings. Implications for both teacher education and study abroad programs are discussed.
Vocabulary Learning Through Audio-Visual Input of Thai Primary School EFL Students
Authors: Lampai Chowarat , Sukying Apisak
Published: May 2023

This research aims to improve the vocabulary knowledge of Thai EFL students by using audio-visual aids as instructional tools. Hopefully, this study serves as an initial foundation to develop students’ vocabulary knowledge and benefit the pedagogical development in Thailand. Consequently, this research aimed to explore the effectiveness of audio-visual instruction in acquiring vocabulary knowledge, with a specific focus on the form-meaning links in Thai EFL primary school students. Additionally, this study investigated the students’ perceptions of audio-visual input in enhancing vocabulary knowledge. The study included one experimental group consisting of 51 sixth-grade students. Two tests were used to measure the reception and production of form-meaning links (L2-to-L1 Translation Test and L1-to-L2 Translation Test). A questionnaire was used to examine the students’ perceptions of the form-meaning links of vocabulary knowledge through audio-visual input.

The results showed that the participants achieved higher scores on the reception and production tests of form-meaning links in the post-test than in the pre-test, revealing statistically significant differences. Furthermore, the students performed better on the reception test of the form-meaning link than on the production test in both time points, and the reception test was also higher in advancement than the production test. Finally, the reports demonstrated that the instructional intervention of form-meaning links of vocabulary knowledge (audio-visual input) positively benefits the development of students’ vocabulary. The findings suggest that students’ reception of vocabulary knowledge through audio-visual input is more advanced than their production of vocabulary knowledge. Moreover, the input of students’ vocabulary knowledge contributes to acquiring and developing their knowledge.