bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessing The Extent Of Habitat Overlap And Resource Partitioning Between Ibex And Livestock In Khyber valley Pakistan
Authors: Javed Faiza , Aslam Asim , Nawaz Dr. Ali
Published: January 2024

Ibex and livestock distribution and habitat preferences were assessed using ecological niche factor analysis (ENFA). The study area was divided into 45 grid cells of 500 x 500 m pixels. Ibex and livestock were documented to occupy 30.61% and 26.5% of the study area, respectively, from June to November. Male and female ibex showed significant sexual segregation during this period. From November to May, male ibex occupied 32.6% of the study area and female ibex 34%. Livestock occupied 19% of the study area from June to September and 14.2% from September to May. The ENFA results indicated that both ibex and livestock show selective habitat preferences but are selecting for the same resources. The first two principal components (PCs) explained 49.3% and 17.88% of the variation in the data, respectively. The first PC was related to distance to settlements, distance to rivers, distance to roads, and rangelands. The second PC was related to rangelands and snow covers. The biplot of ENFA differentiated available habitats from habitat used (by ibex/livestock) through shades of grey, where light grey areas correspond to all the available habitat and dark grey area represented the used area (ecological niche of the animal). The ENFA plot indicated that though ibex and livestock have selective approach towards habitat usage, but selecting for the same resources
Peran Orang Tua dalam Mengoptimalkan Kecerdasan serta Kehidupan Spiritual Anak Menurut Amsal 1:7
Authors: Udam Geissler , Baskoro Paulus Kunto
Published: January 2024

Abstract: The role of parents is very important in a child growth perioed, both spiritually and physically. Often Christian families are not serious about educating their children. Currently, many families focus more on work and ignore their children’s education. Children’ education is handed overe to household assistants of children grow up on their own without God’s direction. In fact, the role of parents is very important fos children’s spiritual growth, especially in children’s intelligence and maturity. Because children are the successors of the family, church and nation. Educational attiention to children is very important. The author uses the basis of the Book of Proverbs as part of examining the role of parents in educating children. This research was conducted using descriptive qualitative methods. Namely research that focuses on exploring data from library soutces. The aim of this research is First, to explain how important the role of parent is in children’s education. Second, examine the role of parents in educating children according to The Book of Proverbs. Third, implementing the role of parents for today’s children in optimizing children’s intelligence and spiritual life.
Abstrak: Peranan orang tua sangatlah penting dalam masa pertumbuhan seorang anak, baik dalam pertumbuhan secara rohani dan jasmani. Seringkali keluarga Kristen tidak serius dalam mendidik anak mereka. Saat ini banyak keluarga lebih befokus kepada pekerjaan dan mengabaikan pendidikan anak. Pendidikan anak diserahkan kepada asisten rumah tangga atau anak-anak bertumbuh sendiri tanpa arahan orang Tuhan. Padahal peran orang tua, sangat penting bagi pertumbuhan kerohanian anak, terutama dalam kecerdasan dan kedewasaan anak. Sebab anak adalah penerus keluarga, gereja dan bangsa. Perhatian pendidikan kepada anak sangat penting. Penulis menggunakan dasar Kitab Amsal sebagai bagian mengkaji peranan orang tua dalam mendidik anak. Penelitian ini dilakukan dengan metode kualitatif deskritif. Yaitu penelitian yang berfokus menggali data dari sumber-sumber pustaka. Tujuan dari penelitian ini adalah Pertama, menjelaskan betapa penting peranan orang tua dalam pendidikan anak. Kedua, mengkaji peranan orang tua dalam mendidik anak menurut Kitab Amsal. Ketiga, mengimplementasikan peranan orang tua bagi anak-anak masa kini dalam mengoptimalkan kecerdasan dan kehidupan spiritual anak.
Saúde e estilo de vida prévios à COVID-19 de pacientes que desenvolveram quadros graves e estiveram internados no Tocantins
Authors: Ferreira Tatiana Vieira , Pereira Araída Dias , Vieira Antonio Hélio , Mariano Sandra Maria Botelho , Pereira Renata Junqueira
Published: January 2024

As primeiras infecções por SARS-CoV-2 foram identificadas no final de 2019, apresentando uma alta taxa de contaminação e representando grandes desafios aos sistemas de saúde globais. Esse estudo, do tipo transversal retrospectivo, foi realizado no Tocantins, com 113 sobreviventes à internação pela Covid-19 grave, submetidos à hospitalização entre abril e setembro de 2020. Buscou-se descrever os perfis sociodemográfico, de saúde e de estilo de vida pré-infecção. A maioria dos sobreviventes era do sexo masculino, de idade mediana igual a 56 anos, autodeclarados pardos, com média escolaridade e renda básica. A maioria não era tabagista ou etilista, mas relatou dificuldades para dormir e pouca ou nenhuma prática de atividades físicas. Considerando as características clínicas, 90,3% dos pacientes relataram a presença de comorbidades preexistentes, sendo a hipertensão arterial sistêmica (54,0%) e a  dislipidemia (33,6%) as mais prevalentes. Devido às condições de saúde prévias, os medicamentos mais utilizados foram anti-hipertensivos (51,3%) e estatinas (16,8%). O perfil da população estudada sugere que  a idade avançada, ser do sexo masculino, possuir baixa escolaridade e baixa renda, fazer uso de fumo e de álcool, a inatividade física e a presença de comorbidades podem ter sido fatores de suscetibilidade, relacionados à gravidade e ao tempo de internação pela Covid-19.
Escola militarizada e gestão democrática; uma análise do manual de procedimentos e orientações aos pais e alunos de uma escola estadual militarizada em Manaus
Authors: De Oliveira Ângela Maria Gonçalves , Pereira Junior Jonas Araújo , Pacheco Cláudia de Oliveira , Da Silva Diana Lima
Published: January 2024

A discussão acerca da gestão escolar tem ganhado destaque frente as reformas educacionais em curso no país. Neste artigo analisaremos sobre a relação do manual de procedimentos e orientações aos pais e alunos de uma Escola Estadual militarizada com os princípios da gestão democrática estabelecida pelo conjunto de leis brasileiras. As referências centrais sobre o objeto de estudo foram Sacristán (2013), Paro (2012, 2016a, 2016b), Saviani (1999 e 2019), Lobardi e Sanfelice (2007). Buscamos empreender uma pesquisa de método marxista (Netto, 2011) a partir da técnica de leitura analítica (Maciel, 2008). O resultado do estudo aponta que a militarização de escolas em Manaus está associada a projetos políticos populistas conservadores que flertam com os anseios da imensa massa da população por uma sensação de segurança, caminhando a passos largos dos dispositivos legais que regulamentam as políticas educacionais.
Evidências científicas atuais sobre a eficácia da terapia cognitivo-comportamental no manejo da ansiedade infantil: uma revisão integrativa
Authors: Souto Ana Paula Brandão , Sousa Larissa Maria do Nascimento , Magalhães Lara Gregório , Almeida Christian Raphael Fernandes , De Araújo Antonia Kaliny Oliveira , Monteiro Ana Ruth Macêdo
Published: January 2024

Introdução: A Terapia Cognitivo-Comportamental (TCC) emerge como uma abordagem significativa no tratamento da ansiedade em crianças, oferecendo uma perspectiva abrangente que integra aspectos cognitivos e comportamentais. Ao focalizar pensamentos disfuncionais e padrões comportamentais prejudiciais, a TCC busca proporcionar ferramentas específicas para que as crianças compreendam e enfrentem seus medos de forma construtiva. Objetivo: refletir sobre a eficácia da terapia cognitivo-comportamental no tratamento da ansiedade em crianças, considerando os resultados de estudos e evidências disponíveis na literatura científica. Metodologia: Revisão integrativa da literatura com a seguinte questão, formulada a partir da estratégia PICO: Qual é a eficácia da terapia cognitivo-comportamental no tratamento da ansiedade em crianças, considerando os resultados de estudos e evidências disponíveis na literatura científica? A coleta de dados foi realizada por meio da Biblioteca Virtual em Saúde (BVS) nas bases de dados MEDLINE, BDENF – Base de Dados de Enfermagem (Brasil), LILACS e Index Psicologia – Periódicos. Finalizou-se a inclusão de quarenta (40) artigos publicados no período de 2018 a 2023 disponíveis em português, inglês ou espanhol, com acesso na íntegra e gratuitos que auxiliam na resposta à questão norteadora deste estudo. A busca ocorreu entre o mês de outubro e novembro de 2023. Resultados: Os resultados recentes na literatura ressaltam a necessidade urgente de fundamentar o tratamento da ansiedade infantil em evidências científicas sólidas, dada a complexidade desse fenômeno que demanda uma abordagem sensível e eficaz. A pesquisa atual aponta para a emergência de modelos inovadores de Terapia Cognitivo-Comportamental (TCC), que podem ser virtuais, presenciais, ser realizados individual ou coletivamente, e integrar técnicas como música, ludoterapia e realidade virtual. Adicionalmente, as novas formas de TCC podem se apresentar em formatos adaptados e personalizados, como a TCC breve, focada em trauma e guiada pelo terapeuta. A eficácia, especialmente no tratamento da ansiedade e transtorno de ansiedade social (TAS), destaca-se, demonstrando benefícios comprovados também para outras condições mentais. Conclusão: A TCC é uma possibilidade eficaz de intervenções para a promoção da saúde mental de crianças e adolescentes, salientando sua importância e necessidade de promover maior aproximação desse campo do saber com a realidade das instituições e famílias.
Sairé, Borari e Borari-Arapium: marcos temporais e identidade(s)
Authors: Cruz Annebelle Pena Lima Magalhães , Ripoll Daniela
Published: January 2024

Alter do Chão e o Sairé são duas dimensões indissociáveis, e essa relação a cada ano torna-se visível na cultura brasileira. Alter do Chão é um espaço geográfico, social e cultural, e o Sairé é um festival, um evento que ocorre neste espaço geográfico, social e cultural. Como relação indissociáveis, significa dizer que há fatores que compõe o Sairé, além das interferências espaço, há também do tempo, cultural, tecnológico, e, sobretudo étnica, o que faz do Sairé complexo. Neste sentido, como se apresentam as influências indígenas no Sairé? O objetivo deste artigo versou em analisar as narrativas que apontam a intersecção entre as dimensões que compõe o Sairé para sua compreensão como cultura e as identidades em jogo Borari e Borari-Arapium em contextos para além do Sairé. A justificativa versa em visibilizar o Sairé como cultura brasileira discutida no âmbito dos Estudos Culturais e no foco está a dimensão étnica do Sairé, apresentando-se como temática inédita nesse sentido, aproximando este artefato representado por infinitos campos de conhecimentos e de uma epistemologia que pode ser utilizada nas mais diversas temáticas, possibilitando a investigação por meio da cultura, na busca de entender sentidos, significados e representações constantemente expressos na linguagem ou nas próprias ações dos sujeitos em relação aos ao que circulantes em suas culturas por meio dos Estudos Culturais. Contribuindo assim, para a compreensão das culturas por meio de lentes não essencialistas e não binárias sobre as diversas identidades atreladas ao festival. O que traz novas perspectivas acerca dos modos de análise a partir dos Estudos Culturais. É uma pesquisa qualitativa, como método bibliográfico, em que as análises se deram através de livros e artigos escritos acerca do Sairé de Alter do Chão. Teve como referencial teórico os Estudos Culturais que empreendem estratégias para compreender as formas de produção de significados, como a disseminação dos mesmos nos contextos culturais. Concluindo-se que é comum nas obras analisadas, o enlaçamento recorrente de temáticas que ressaltam aspectos como identidade, religião, sagrado, profano, mitos, folclore, cultura, tradição e turismo. Além de trazer reflexões sobre a luta atual para afirmar identidade em relação ao Sairé, a Etnia Borari e a Etnia Borari-Arapium.
Research Progress of Cancer Vaccine
Authors: Liu Silu
Published: January 2024

Cancer has now become the major cause of pre-mature death around the world. In the past decades, research on tumor immunotherapy has advanced significantly, with numerous studies being evaluated in the clinical setting. The cancer vaccine is regarded as an advantageous approach in the immunotherapy of solid tumors. Preventive cancer vaccines can be injected in advance to reduce the risk of having cancer, while therapeutic vaccines can be used to trigger immunoresponse after having cancer. For example, recent studies have found that vaccination with one or more doses of the HPV vaccine produces more than 90 percent effective protection. In the meantime, the best and safest way to prevent hepatitis B is to get the hepatitis B vaccine. This paper introduces the mechanisms of both two types of cancer vaccines, and focuses on the explanation of the two cancer vaccine therapies. As a systematic review, it also highlights their current states and possible future improvements.
Physical Activity and Health in African American Youth
Authors: Chen Wenjing
Published: January 2024

Promoting individuals' participation in physical activity (PA) holds significant significance in the field of public health due to the demonstrated preventative impact on diverse metabolic disorders, such as cardiovascular disease and type 2 diabetes. There is a lack of research on how race and ethnicity affect people's propensity to exercise and how to best encourage them to get moving. However, the research that is currently available suggests that a sizeable percentage of African American (AA) Youths do not achieve the levels of PA that are suggested. The primary objective of this study is to give a preliminary examination of the demographic features and health disparities that are experienced by AA adolescents. Additionally, it aims to explore the various factors influencing their engagement in PA and propose viable interventions to address these issues.
Monoclonal Antibodies: Current Status and Future Innovations in Targeted Therapy
Authors: Pang Bo
Published: January 2024

This extensive dissertation offers a detailed examination of monoclonal antibodies (mAbs), their present uses, prospective future developments, and current difficulties. The study investigates the development and mechanism of mAbs, their function in different diseases, and their effectiveness based on clinical trials and case studies. Additionally, it covers potential side effects, negative reactions, and risk reduction techniques. Additionally, it explores the potential advancements, fresh uses, and improvement techniques for mAbs in the future. The effectiveness of mAbs in monotherapy and combination therapy, as well as how the tumor microenvironment and different mAb isotypes can influence this, are also covered in the document. It also explores how mAbs' potential toxicity and side effects may relate to their effectiveness.
The Therapeutic Effect and Potential Application of Psilocybin
Authors: Liu Tianran
Published: January 2024

Mental illness is a hot topic of concern worldwide. The psilocybin has great potential in the treatment of mental disorders, but there is still a research gap on whether it can truly be applied in the treatment of mental disorders. Therefore, this research explores the feasibility of psilocybin’s true application in the treatment of mental disorders by collecting relevant literature on its experiments in recent years, analyzing the data and experimental results in detail. Research has found that in the treatment of mental disorders, psilocybin does have significant effects compared to traditional drugs. Psilocybin’s role is more pronounced in cancer patients with more severe and complex mental disorders, greatly reducing their depression index and effectively controlling the condition of substance abuse patients. And through popular science, some healthcare professionals who care for patients with eating disorders hope to apply psilocybin for treatment. Psilocybin also does have certain unresolved side effects. Overall, from a scientific perspective, psilocybin can indeed effectively treat mental illnesses, and morally speaking, healthcare professionals are willing to introduce psilocybin into the treatment of patients with mental illnesses. One day, when psilocybin is widely used to treat mental illnesses, it will be a significant progress in medical history.
A Systematic Review of Gene Editing Therapy for Acquired Immunodeficiency Syndrome
Authors: Zhou Yize
Published: January 2024

Acquired immunodeficiency syndrome (AIDS) is a deadly immunological disease that affects the immune system and becomes more common in recent years, which is brought on by the inflection of human immunodeficiency (HIV). The treatment of AIDS has always been a major challenge for the medical community to overcome because the existing treatment methods are not universal. At present, the scientific community is focusing on gene editing therapy, and the feasible tools are zinc finger nucleases (ZFNs), transcription activator-like nucleases (TALENs), and clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9). Since gene editing technology has advanced so quickly, gene editing therapy is now thought to be one of the most promising AIDS treatment. Though these systems are powerful and efficient, there are still several serious challenges that scientists should face. The clinical safety issues have always existed and been controversial, especially after He Jiankui’s case that editing AIDS-resistance human embryos coming to the light. And the legal regulations were strongly criticized due to gaps in the bottom line of scientific research. This review summarizes existing applications of gene editing in AIDS with the safety and ethical issues of clinical application, searching for the relevant solutions to the current challenges.
Comparative Analysis of International Health Policies: A Comparison of COVID-19 and post-COVID-19 Health Policies
Authors: Du Runyi
Published: January 2024

This research paper discusses the dynamics of COVID-19 health policies, focusing on the strategies of China and Germany in managing the pandemic, and exploring the opportunities and challenges in enhancing healthcare policies in the post-COVID era. The COVID-19 pandemic has exposed the strengths and vulnerabilities of healthcare systems globally, underscoring the need for adaptable health policies. China and Germany employed distinct strategies in responding to the pandemic. The paper compares these strategies and their outcomes. The comparative assessment highlights the importance of early and sustained interventions, as China's aggressive suppression approach yielded better results than Germany's mitigation strategy. The lessons learned from China and Germany's pandemic responses provide valuable insights into the importance of preparedness and adaptability in healthcare policies. These lessons should guide future policies and actions to build a better global healthcare system.
Comparing the Efficacy and Safety of the Pfizer BNT162b2 Vaccine with Other Alternatives Under COVID-19
Authors: Tan Jingdong
Published: January 2024

In an epidemic or pandemic caused by a pathogen that has never been encountered, scientists have to compete against time to develop new vaccines. Vaccination effectively prevents the spread of the disease and saves lives. Under the COVID-19 crisis, several types of vaccines were developed and authorized as Emergency Use Authorization (EUA), including the first mRNA vaccine product ever approved by FDA, the BNT162b1. The transiently expressed mRNA does not encounter the problem of genome integration with the host and it takes less time to develop, which differentiates it from alternative types such as inactivated and subunit vaccines. This paper attempts to present the difference of the BNT162b2 mRNA vaccine from the Novavax subunit vaccine, and the Sinovac inactivated vaccine, in terms of COVID-19 prevention and adverse events, therefore attempts to provide a better understanding of the behaviors of mRNA vaccines under COVID-19.
Role Of PD-1 Immune Checkpoint Inhibition in Lung Cancer Treatment
Authors: Jiang Xiaokun , Li Kunjian , Zeng Shiqing
Published: January 2024

Non-small cell lung cancer (NSCLC) can be distinguished by histopathology and tumor markers. The treatment methods of NSCLC mainly include radiotherapy, chemotherapy, surgical treatment and TCM therapy. PD-1/PD-L1 immunotherapy has an advantage in combination therapy, producing a low-toxic, long-acting antitumor immune response in cancer therapy. This thesis describes the main methods of NSCLC therapy, details the PD-1/PD-L1 pathway and immunotherapy, and studies applications of three monoclonal antibodies in monotherapy and combination therapy. We conclude that the combination therapy has the outstanding advantage of safety, mild effect and prediction, but the problem of drug resistance to PD-1/PD-L1 needs to be solved urgently.
Research Progress of CRISPR/Cas9 Application in Rice Cultivation
Authors: Mi Xiaohan , Yu Jiawen , Zhang Jiaqi , Zhong Nike
Published: January 2024

Rice, being one of the world's most important staple crops, plays an important role in global food security and sustainable agriculture. The CRISPR/Cas9 gene editing technology has attracted widespread attention globally. With its precision and simplicity, rice breeding and research now heavily rely on the CRISPR gene editing method. The rice genome has been fully sequenced and intensively studied. Genome editing in rice holds great potential for variety improvement and agricultural production. In recent years, many studies have reported successful cases of gene knockout, point mutations, and targeted genome insertions using CRISPR-mediated genetic improvement strategies in rice. Using CRISPR gene editing technology to introduce new beneficial traits in rice, such as increased quality and nutritional value, disease resistance, stress tolerance, and greater control of rice growth and development has shown great potential. However, despite the broad prospects of CRISPR technology in rice, there are still many challenges and technical limitations to overcome, and issues regarding precision and safety remain unresolved. This review intended to provide an overview of the CRISPR technology's principles, methods, and researched progress in rice, as well as to analyze its possible benefits and difficulties in rice breeding while also providing information on its potential future applications.
Combining Robotic Vision with Non-Invasive Brain-Computer Interfaces Development and Future Directions
Authors: He Fengtao
Published: January 2024

The profound growth in brain-computer interface (BCI) technology has brought forth novel interdisciplinary applications, particularly in the realm of robotics. This review delves into the challenges of using non-invasive BCIs for precise robotic arm operations, with an emphasis on the transformative potential of integrating BCI with machine vision. Based on some problems in BCI applications, this paper emphasizes the use of machine vision combined with BCI signals to help non-invasive brain-computer interfaces improve the correctness and efficiency. Through detailed analysis, it is demonstrated how computer vision complements BCI, ameliorating issues like inherent noise and decoding inefficiencies associated with non-invasive BCIs. Moreover, the discussion touches upon the enhanced user experience offered by this integrated approach, and the potential it holds for addressing the compatibility challenges in BCIs. Although the combination of the two technologies can solve mutual problems, there are also certain limitations. For example, two different data may be more complex, so there are higher requirements for algorithms and processing methods. In addition, the development of a combination of two devices The system will have higher overhead, making it impossible for the average person to afford the cost of using it at the same time。As BCI technology continues its upward trajectory, this synthesis with robotic vision heralds a new era of harmonized human-machine interactions.
Gene Drive System Based on CRISPR/Cas9 in Mosquito Control for Preventing Malaria
Authors: Wang Zimeng
Published: January 2024

Malaria is a disease transmitted by mosquitoes to humans and has symptoms varying from mild such as fever and headache to severe such as loss of consciousness, bleeding, or even death. Although there are a few other pathways to get infected with malaria, female mosquitoes belonging to the genus Anopheles infected by pathogen parasites belonging to Plasmodium have been considered as the predominant media of transmission, and elimination of this pathway could greatly assist in controlling the spread of malaria among populations. CRISPR/Cas9, as an emerging genome editing technology, functions by designed guide RNA (gRNA) for targeting sequence and Cas9 for cleaving targeted double-stranded DNA. Due to the great power of CRISPR/Cas9 in gene editing, it has significantly facilitated the study of mosquito control. This review describes the potential and applicable properties of the CRISPR/Cas9 system in restricting the spread of malaria via genetic screening of mosquitoes and gene-drive population suppression by modifying female mosquito fertility to reduce pathogen infection rate by targeting alleles from mosquitoes and pathogen to prohibit mosquito infections or retard the parasite development process. Furthermore, this review discusses the urgency that adjusting CRISPR/Cas9 technique to be affordable by more performers with low off-target effect. In conclusion, CRISPR/Cas9 system is expected to affirm the applicability of the technique in nature to restrict the spread of malaria among populations.
CAR-T Therapy: Defective Currently but Promising in the Future
Authors: Wu Haonan
Published: January 2024

Since CAR-T therapy was approved by the FDA in 2017, this therapy has become one of the most important cancer treatments for patients with some certain hematological malignancies. However, severe adverse effects, such as cytokine release syndrome (CRS) and neurotoxicity, cause low survival. The existed and approved drugs against these side effects would possibly become the trigger of other side effects or reduce the effect of therapy. Besides, CAR-T therapy that has been successfully applied in hematological malignancies shows weak efficacy in solid tumors. In this article, we introduce main limits of this promising therapy, integrate existed solutions and explore possible strategies to overcome these challenges. With more profound studies about CAR-T cell and associated side effects and limitations, we believe that there would be more novel strategies to optimize this revolutionary therapy will appear and be realized in the foreseeable future.
Research progress of monoclonal antibody in the treatment of lung cancer
Authors: Qin Yi , Yu Qinyi , Zhang Yaqi , Zhou Chenyan
Published: January 2024

The largest cause of cancer-related deaths is lung cancer. Conventional therapies like chemotherapy, surgery and radiation therapy have been widely used in treating cancer including lung cancer. However, the fact is that these conventional therapies may generate severe adverse effects. For example, they are lack of specificity, they could not treat the target tissue specifically. When processing these conventional treatments, adjacent normal cells and tissues may be harmed. With this kind of problem in treating lung cancer, more and more therapeutic drugs and therapies are being develop to reduce such problems. Monoclonal antibody treatment is an example. Since the concept of magic bullet had been introduced by Pual Ehrlich, scientists have been inspired to conduct further and deeper research into monoclonal antibody treatment. In this concept, antibodies are said to be magic bullets since they are useful tool to treat foreign cells. Since then, scientists had been devoting themselves to the development of monoclonal antibodies. These days several monoclonal antibodies are FDA approved. Since monoclonal antibodies work through various mechanisms, it plays an important role in cancer therapies. One monoclonal antibody is specific to only one type of antigen and it works by trigger the immune system. Monoclonal antibodies would become the focus of future research.
A Brief Talk on the Current Situation Prevention and Treatment Strategies of Diabetes in China
Authors: Geng Jia
Published: January 2024

Nowadays, diabetes is the fastest growing disease among the high incidence chronic diseases in the world. It is one of the main causes of cardiovascular disease, renal failure, and other major diseases. The current situation and prevention of diabetes is one of the key research topics. Some researchers have found the current situation and progress of diabetes in the world, but there is still a lack of unified explanation and systematic research on specific prevention strategies for diabetes in China. Therefore, this paper collects the data from 2008, 2013, and 2018, analyzes the data of China by using the methods of correlation analysis and prediction analysis, and proposes the prevention and treatment measures for diabetes based on the research on the etiology and status of diabetes, and provides a theoretical reference for solving related problems. This study found that the prevalence of diabetes in China showed an increasing trend year by year, and will continue to grow in the future. Men have a higher risk of diabetes than women, and people over 50 years old have a higher risk of diabetes than other age groups. So the prevention and treatment of diabetes, especially diabetes among Chinese people, is very important.
Icis Treatment for Different MSI Colorectal Cancer: Theoretical Basis, Status Quo And Outlook
Authors: Gu Wenjie , Liu Haotian , Ma Kuo
Published: January 2024

As the third cancer worldwide, the incidence and the cancer-related mortality is both high in colorectal cancer (CRC) patients. The treatment of CRC has standard methods, including radiotherapy, chemotherapy and other general therapy. However, these systemic therapies are not specific, which are also toxic for normal cells and show many side effects in patients. New immunotherapeutic strategies have changed the landscape of treatment of metastatic CRC (mCRC), especially immune checkpoint inhibitors (ICIs). After research, the condition of microsatellite instability (MSI) has proven to be one of the main influencing factors of ICIs' efficacy. This review comprehensively analyses the possible mechanisms underlying the varying efficacy of ICIs in the treatment of different MSI tumors and evaluates potential therapeutic strategies that offer possible ways to overcome resistance mechanisms.
COVID-19 vaccination efficacy and safety in individuals with solid tumors or hematologic malignancies
Authors: Zhao Chengzhi
Published: January 2024

Cancer patients are immunocompromised, and inadequate antibody response after the SARS-CoV-2 vaccine (SC2V), which puts them at increasing risk of Covid-19 severe disease. Moreover, the data on adverse reactions in those patients is fragmented and lacking after the SC2V. The objective of this study was to evaluate the immunogenicity and effectiveness as well as safety of the SC2V in those patients. The data for this study was obtained from the Pubmed database, as of August 23, 2023. A total of 614 documents were collected. The period of first, second, third and fourth doses of the SC2V are labeled as T1, T2, T3 and T4, respectively. The serologic conversion rate of the patients following vaccination served as a measure to evaluate the vaccine's immunogenicity. As a result, 17 researchers altogether were included. The effect size (ES) for serological conversion rate of solid tumors (STs) were 0.51 (95% CI: 0.40-0.67), and 0.88 (95% CI: 0.85-0.92) respectively, after T1 and T2. The ES for serological conversion rate of hematologic malignancies (HMs) were 0.08(95%CI:0.00-1.61), 0.60(95%CI:0.44-0.82, 0.84(95%CI:0.77-0.93), respectively, after T1, T2, and T3. Comparing the serologic conversion rate between T2 and T3 for STs as well as HMs, it revealed poor outcomes for HMs, which may be related to different types of cancer and treatment regimens. In all studies, local discomfort was the most frequent adverse response. The chemotherapy group had the greatest influence on the SARS-CoV-2 vaccine immunogenicity, compared to other treatments. In conclusion, SC2V is safe and effective for cancer patients.
Oral Health: The Potential of Mesenchymal Stem Cells in Treating Various Oral Diseases and Promoting Tissue Regeneration
Authors: Wang Yifan
Published: January 2024

The WHO Global Oral Health Status Report (2022) estimates that over 3.5 billion individuals worldwide have an oral disease. Most of the cases are dental caries, periodontal disease, tooth loss etc. Tooth loss will not only affect the balance of the oral environment but also cause negative effects on facial development and the patient's psychological condition. At present, The implement of oral stem cells to encourage tissue regeneration has become a hot trend. Among them, Periodontal Ligament Stem Cells (PDLSCs) and Dental Follicle Stem Cells (DFSCs) have been discovered it’s potential to promote tooth regeneration. Scientists proposed a variety of different treatment methods, including the use of advanced bioengineered technology to further target different oral diseases. So far, It is firmly established that oral stem cells have the potential to boost tissue regeneration.
Treatments and Prevention of CVDs by Taking an Insight into the Mechanism of Cardiovascular Aging
Authors: Shi Peijie
Published: January 2024

In an era of rapid technological advancement, a notable and convincing demographic trend is emerging: a significant increase in the elderly population. This demographic shift is represented by numerous factors, including enhanced healthcare, medical breakthroughs, and improved living standard conditions. This transformation brings numerous concerns for the health and well-being of the elderly. This concern is particularly pronounced when considering the impact of cardiovascular aging, a critical facet of their overall health that carries substantial implications for governments and healthcare systems worldwide. However, people’s knowledge of these diseases and our ability to control epidemics is still limited. Cardiovascular aging brings many changes to our lives and poses high risks for the elderly. This report aims to analyze cardiovascular changes and combine existing medical methods to make efficient suggestions. To address the challenges posed by the aging population to cardiovascular disease, it is important to cultivate a comprehensive approach that includes risk factor management, lifestyle interventions, and advanced therapies.
Research on Design Innovation of Graphical Advertisement Based on Visualization and Graphics
Authors: Liu Dou
Published: January 2024

This paper explores the application of the combination of "visualization" and "graphics" in the expression of graphic advertising design. Based on the contents of psychology and advertising, literature research, comparative analysis, empirical research, and interdisciplinary research are used to identify feasible ways to present visual expressions that combine "visualization" and "graphics". The technology that combines "visualization" and " graphics" has enriched the presentation of graphic design, broadened the expression of graphic design, and provided new room for the creation and expression of two-dimensional graphic advertising design.
Usage pattern analysis of academic articles from Chinese journals
Authors: Liu Yuxin , Wang Shiqin
Published: January 2024

Usage metrics have become increasingly popular in scientometric with the advent of electronic resources. While most current researches relied on the usage data retrieved from English publishers. In this study, the usage data was extended to Chinese publishers. We collected and analyzed the usage data of six well-known Chinese OA (Open Access) journals in different fields from journals’ official websites and Chinese Academic Journals Full-text Database (CJFD) in China National Knowledge Infrastructure (CNKI). It was found that websites’ information architecture affected usage pattern. “Progressive rule”-based site guided users to view full-text articles more than download them and “parallel rule”-based site guided users to download full-text articles more than view them. CNKI proved its popularity in China. Although CNKI is a non-OA platform and has a time delay in indexing full-text articles, but they still attracted a large number of users. PDF tended to be the preferred format than HTML in most journals in the study. Also, CNKI citation were more skewedly distributed than usage data in most journals and it showed strong or moderate correlation between CNKI citation and CNKI full-text downloads in most journals. Finally, it depicted that usage data of most articles was at their peak around pagination month and at the bottom at very earlier or later months.
Study for Iris Classification Based on Multiple Machine Learning Models
Authors: Zhou Yihan
Published: January 2024

Classification algorithms in machine learning aim to classify data into different kinds, which is important in data mining. It is important and challenging to select the classification model with high accuracy and efficiency. To address this, this paper compares and analyzes Multilayer Perceptron (MLP)with different machine learning methods, including K-NearestNeighbor (KNN), Support Vector Machine (SVM), Logistic regression, decision tree, and random Forest. All models are trained to classify different kinds of Iris to show further comprehension of different models. All the related models are evaluated with metrics called accuracy and confusion matrices. The experimental results show that the confusion matrices based on various models are similar but MLP overperforms other models in terms of accuracy. With sufficient nodes per hidden layer for backpropagation, MLP has a remarkable ability to analyze and provide projections. With this superiority, it is expected that the neural network can have better performance in classification soon. After understanding the strength and limitations of various classification algorithms, the optimization models are expected to be developed to better solve real-world problems.
Regulation of Media in the Electronic Age
Authors: Gu Zeyu
Published: January 2024

In the electronic age, people’s social interactions are entirely changed, which is caused by the internet. Oversharing makes the social media be fulled of “too much information” (T.M.I.), reducing people’s capacity of judgement. It will bring a deleterious effect on the quality of information circulating. Thus, the internet has become an immense source of entertainment easily. Judging from the “culture industry” proposed by the Frankfurt School, it can be seen that social media has become a new “culture industry”. This “culture industry” incentivizes mass production of low-quality entertainment. Therefore, the social media regulation and possible remedies to the psychological effects of social media must be valued.
Optimal design of modular soft body crawling robot structure based on genetic algorithm
Authors: Guo Changxin
Published: January 2024

This paper explores how a soft robot can be designed and built with a limited material framework to optimize evolutionary iterations to achieve the fastest crawling configuration. The limited framework of the soft robot is based on a modular design, which divides the soft robot into several cubes composed of masses and springs. The morphological self-optimization of the modular soft robot is controlled by set variable parameters combined with an incentive mechanism and an evolutionary algorithm.
The application of gene-editing technologies in plants
Authors: Qin Yi'e
Published: January 2024

In recent years, we have witnessed a spurt of progress in modern molecular biology, thus enabling the perfection of genome sequencing.  As a result, research into gene function has gained popularity among scientists. Since gene editing has served as an essential tool for the exploration of plant gene function, the utilization of genome editing technology contributes most to the genetic upgrading and crop breeding through modification on plant genome. Typical cases where CRISPR/Cas system has been applied to model species including Arabidopsis thaliana, Nicotiana tabacum and Oryza sativa to alleviate salinity stress and figure out the gene behind traits relative to their architecture and yield. The modified CRISPR/Cas9 system requires only simple cloning compared with the other two types of gene editing tools and the design of target sequences is easy, the construction of backbone vectors is simple, and the cost is relatively low. The CRISPR/Cas9 system, which was awarded the 2020 Nobel Prize in Chemistry, has transformed the molecular life sciences by enabling researchers to accurately modify the DNA of animals, plants, and microorganisms. This review thoroughly introduced gene editing technologies currently applied in plants, including map cloning, RNAi technology and targeted genome editing technology, containing ZFNs, TALEN, CRISPR/Cas9. The review revealed the difficulties and potential uses of genome editing technology in plants while concentrating on its theory and viability.
Applications of CA125 in Ovarian Cancer
Authors: Wu Wanlin
Published: January 2024

Ovarian cancer is currently the most fatal among gynecological malignancies with a low survival rate, especially in the case of type II tumors. Cancer antigen 125, the primary protein biomarker associated with ovarian cancer, has been researched for its involvement in the ovarian cancer pathogenesis and its potential applications in enhancing both accurate diagnostics and effective therapies. Research has investigated the connections between CA125 and several biological pathways, revealing their associations with cancer cell proliferation and migration. Further research aims to utilize CA125 for a more accurate diagnosis and potential treatments for ovarian cancer. Approaches have been established to address the low specificity of CA125 diagnostic tests, including altering the traditional CA125 value threshold used for ovarian cancer diagnosis and detecting CA125 alongside other antigens. CA125-specific cancer vaccines and immunotherapies are currently undergoing clinical trials and are being developed for future clinical use.
Current Study on Deep Brain Stimulation for Parkinson's Disease
Authors: Hu Dingyuan
Published: January 2024

This paper emphasizes the evolution and application of neural electrical stimulation in the context of Parkinson's disease. During the last several decades, Deep Brain Stimulation (DBS) has become a highly successful viable treatment choice for patients with advanced stages of PD and other motor disorders. DBS utilizes a device similar to a pacemaker to administer constant electrical signals to targeted regions within the brain to help patient relieve the symptoms. The DBS has been involved in the rehabilitation process of more than 80000 people, and most of them are patients with PD. Based on the specific symptoms show by patients, several targets have been approved as effective DBS targets for patients with PD. These include subthalamic nucleus (STN), globus pallidus internus (GPi), ventral intermediate nucleus (Vim), and pedunculopontine nucleus (PPN). Hence, understanding the applications and evolution of DBS techniques have significant importance for future studies of PD and brain functions.
Reseach Progress and Future of Phage Therapy in Klebsiella Pneumoniae Infection
Authors: Song Ruohan
Published: January 2024

Bacteriophages are widely found in nature and can specifically lyse bacterial viruses. Because of the extensive use and abuse of antibiotics, bacterial resistance has become a global problem. Klebsiella pneumoniae is one of the most common clinical drug-resistant bacteria, and the incidence is increasing year by year. Because many strains of Klebsiella pneumoniae are multidrug-resistant, treatment has been difficult. And this resistance has been increasing in recent years, adding to this many new difficulties due to the misuse of antibiotics. The phage can be a new way treat Klebsiella pneumoniae by lysis, which is non-toxic, non-secondary drug resistance, highly specific and penetrating, however, it has not been widely used in clinical practice and only a few cases have been reported. Through the in-depth study of phages, can play an important role in drug-resistant Klebsiella pneumoniae. The paper will introduce the characteristic Klebsiella pneumoniae and phage therapy, and also summarize development of Current animal models and clinical trials of phage therapy in Klebsiella pneumoniae.
Cancer Stem Cells: the elusive tumour population discussed
Authors: Lian Bohan
Published: January 2024

Cancer Stem Cells (CSCs) are specific tumour populations playing important roles in tumour initiation, progression, and resistance to conventional therapies. Their involvement in processes like epithelial-to-mesenchymal transition makes them crucial players in metastasis. Traditional therapies often fall short in targeting CSCs due to their quiescent nature during treatments and their adaptability, such as increased resistance post-radiotherapy. CSC antigen heterogeneity also poses challenges to targeted therapy. Examples of CSC-targeting approaches are CAR-T cells and oncolytic viruses, discussed in this paper. Stem cells, present promising avenues for CSC-targeted therapies due to their potential as immune progenitor cells and inherent attraction to CSCs. This review provides an overview of the roles of CSCs in cancer, some examples CSC-targeted cell therapies, the potential of stem cells in these therapies, and the challenges and future directions in this critical area of cancer research.
EEG Signal Filtering Method and Comparison Between Modern to Classical Filter
Authors: Zheng Yunyang
Published: January 2024

In neuroscience and therapeutic applications, electroencephalography (EEG) has become a crucial technique for gaining understanding of brain activity and cognitive processes. In order to improve signal quality, lower noise, and extract useful information from EEG data, preprocessing is essential. In the context of EEG signal processing, this study compares the effectiveness of three frequently used filtering methods: the median filter, average filter, and Gaussian filter.This study's main goal is to assess and compare how well these filters work to reduce the various forms of noise that may be found in EEG data, such as physiological artifacts, environmental interference, and electrode noise. The study makes use of a large dataset of EEG recordings that spans a range of experimental settings and mental states. The filtering methods are methodically applied to the unprocessed EEG data, and then the effects on signal fidelity and quality are thoroughly examined.The findings of this investigation shed important light on the advantages and disadvantages of each filtering strategy used in EEG data processing. In the end, the conclusions from this comparison study help offer criteria for choosing a suitable filtering approach based on the unique properties of EEG data and the research goals.The findings of this investigation offer important new understandings of the advantages and disadvantages of each filtering strategy used in EEG data processing. Finally, depending on the unique properties of the EEG data and the study goals, the findings from this comparison analysis help offer criteria for choosing an acceptable filtering approach.