bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH UKURAN PERUSAHAAN, PROFITABILITAS, AGRESIVITAS PAJAK, DAN RISK MINIMIZATION TERHADAP PENGUNGKAPAN CORPORATE SOCIAL RESPONSIBILITY
Authors: Kurniawan Rino , Deliza Henny
Published: April 2023

Tujuan riset ini ialah untuk mendapatkan bukti empiris bahwa adanya pengaruh Ukuran Perusahaan, Profitabilitas, Agresivitas Pajak, dan Risk Minimization Terhadap pengungkapan Corporate Social Responsibility. Data riset ini diperoleh dengan data sekunder yang diambil dari Bursa Efek Indonesia pada periode 2017-2020. Sampel yang digunakan pada riset ini sebanyak 17 perusahaan pertambangan yang terdaftar di Bursa Efek Indonesia pada periode 2017-2020. Teknik pengambilan sampel yang digunakan adalah purposive sampling. Penelitian ini menggunakan metode analisis regresi berganda. Alat analisis yang digunakan untuk pengujian hipotesis adalah SPSS. Hasil penelitian ini menunjukan bahwa variabel Ukuran Perusahaan, Profitabilitas, Agresivitas Pajak tidak berpengaruh, sedangkan Risk Minimization berpengaruh terhadap pengungkapan Corporate social responsibility.
INSTITUSIONAL OWNERSHIP TERHADAP KINERJA PERUSAHAAN PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Handini Annisa Dwi , Martiningtyas Catur Rahayu
Published: April 2023

Tujuan penelitian ini untuk menguji pengaruh Institutional Ownership, leverage, firm size, dan likuiditas, growth opportunity terhadap kinerja perusahaan. Pada perusahaan manufaktur dari sub-sektor industri barang konsumsi, sektor industri dasar dan kimia serta sektor aneka industrian yang terdaftar di Bursa Efek Indonesia (BEI). Sedangkan variabel dependent yang digunakan adalah kinerja perusahaan. Data yang digunakan adalah data yang diperoleh dari laporan keuangan perusahaan manufaktur yang terdapat di Bursa Efek Indonesia (BEI) periode 2017-2021, sampel penelitian berjumlah 90 perusahaan yang dipilih menggunakan metode purposive sampling. Teknik analisis data menggunakan E-views 9. Berdasarkan hasil penelitian ini menunjukkan bahwa institutional ownership dan leverage memiliki pengaruh negatif secara dan signifikan terhadap kinerja perusahaan. Variabel firm size dan likuiditas memiliki pengaruh positif secara dan signifikan terhadap kinerja perusahaan. Sedangkan variabel growth opportunity tidak mempengaruhi kinerja perusahaan.
PENGARUH STRATEGIC ORIENTATION, WORK MOTIVATION, WORK VALUE DAN WORK ENVIRONMENT TERHADAP JOB PERFOMANCE PADA KARYAWAN BANK SYARIAH INDONESIA DI JAKARTA UTARA
Authors: Dewanto Naufal Rifaldy , Deasy Aseanty
Published: April 2023

Penelitian ini bertujuan untuk menganalisis Pengaruh strategic orientation, work motivation, work value dan work environment terhadap job performance pada karyawan Bank Syariah Indonesia cabang Jakarta Utara. Penelitian ini menggunakan responden yang didapat sesuai kriteria dengan metode pengambilan sampel sensus sebanyak 120 karyawan dari 3 kantor cabang pembantu. Penelitian ini menggunakan cross sectional dan pengolahan datanya menggunakan software SPSS 25.0. Hasil penelitian ini menunjukan bahwa strategic orientation memiliki pengaruh positif terhadap job performance, work environment memiliki pengaruh positif terhadap job performance, work motivation memiliki pengaruh positif terhadap job performance, dan work value memiliki pengaruh positif terhadap job performance. Dari hasil penelitian ini diharapkan dapat memberikan masukan bagi manajemen perusahaan agar menyesuaikan jam kerja dengan gaji yang karyawan terima sehingga karyawan termotivasi untuk bekerja lebih giat dan menganggap pekerjaan mereka sebagai sesuatu yang berharga yang dapat meningkatkan work value yang kemudia mempengaruhi peningkatan job performance.
FAKTOR YANG MEMPENGARUHI TURNOVER INTENTION DENGAN KOMITMEN ORGANISASIONAL SEBAGAI PEMEDIASI PADA KARYAWAN HOTEL (STUDI KASUS HOTEL MUTIARA MERDEKA)
Authors: Tereza Ledia , Ramashar Wira , Azmi Zul
Published: April 2023

Tujuan dari penelitian ini adalah menganalisis faktor-faktor yang diduga mempengaruhi timbulnya turnover intention pada karyawan, yaitu stres kerja, kepercayaan atasan, dan komitmen organisasional, serta menganalisis peran mediasi komitmen organisasional antara stres kerja dan kepercayaan atasan terhadap turnover intention. Penelitian ini menggunakan metode kuantitatif dengan jenis data primer kuesioner pada skala 1-5. Penelitian ini dilakukan di Hotel Mutiara Merdeka Pekanbaru dengan jumlah karyawan 71 orang dengan menggunakan teknik sampling jenuh menggunakan analisis Structural Equipment Modeling (SEM) dengan aplikasi SmartPLS 4.0. Hasil pengujian hipotesis ini menjelaskan bahwa stres kerja berpengaruh positif dan signifikan terhadap turnover intention, kepercayaan atasan berpengaruh negatif dan tidak signifikan terhadap turnover intention, stres kerja berpengaruh negatif dan signifikan terhadap komitmen organisasi, kepercayaan atasan berpengaruh pada komitmen organisasi yaitu positif dan signifikan, komitmen organisasi berpengaruh negatif dan tidak signifikan terhadap turnover intention, stres kerja yang dimediasi komitmen organisasi berpengaruh positif dan tidak signifikan, dan kepercayaan terhadap atasan yang dimediasi komitmen organisasi berpengaruh negatif dan tidak signifikan turnover intention. Kesimpulan penelitian ini adalah komitmen organisasional tidak dapat memediasi stres kerja dan kepercayaan atasan terhadap turnover intentions atau No Mediation.
PENGARUH MOBILE BANKING, INTERNET BANKING, NON PERFORMING LOAN DAN BIAYA OPERASIONAL PENDAPATAN OPERASIONAL TERHADAP PROFITABILITAS RETURN ON ASSET BANK PADA PERUSAHAAN PERBANKAN YANG TERDAFTAR DI BEI TAHUN 2017 – 2021
Authors: Leviani Novita , Wiyono Slamet
Published: April 2023

Fenomena dapat digambarkan ditandai dengan pergeseran kondisi kesehatan yang ditunjukkan oleh sektor perbankan dalam perekonomian Indonesia. Pertumbuhan globalisasi dan pasar bebas merupakan ancaman bagi ekonomi seluruh planet ini. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh kredit bermasalah, pendapatan dan beban operasional, mobile dan internet banking, dan pengembalian aset bank yang terdaftar di BEI antara tahun 2017 dan 2021. Penelitian ini menggunakan metodologi kuantitatif. dengan teknik pengambilan sampel berdasarkan purposive sampling, dan digunakan Eviews Versi 10 untuk melakukan analisis terhadap data yang terkumpul. Dalam penelitian ini, data dianalisis dengan menggunakan metode analisis linier berganda dari data panel. Untuk mengevaluasi hipotesis, alat statistik seperti uji-t, uji-F, dan koefisien determinasi yang digunakan. Fungsi regresi berganda yang ada dapat digunakan secara efektif sebagai prediktor untuk Pengembalian Aset. Hasil penelitian menunjukkan bahwa Mobile Banking, Internet Banking, dan Non Performing Loan (NPL) berpengaruh positif dan signifikan terhadap ROA, sedangkan Biaya Operasional Pendapatan Operasional (BOPO) berpengaruh negatif dan signifikan terhadap ROA. Fungsi regresi berganda yang ada juga dapat digunakan secara efektif sebagai prediktor Return on Equity.
PENGARUH KOMITE AUDIT, KONDISI KEUANGAN PERUSAHAAN, DAN UKURAN PERUSAHAAN TERHADAP OPINI AUDIT GOING CONCERN
Authors: Dewi Bianca Nafta Avia , Slamet Wiyono
Published: April 2023

Tujuan peneIitian adaIah untuk mengetahui apakah pengaruh komite audit, kondisi keuangan perusahaan, dan ukuran perusahaan berpengaruh positif atau negatif terhadap penerimaan opini audit going concern pada perusahaan sektor non-cycIicaIs konsumen yang terdaftar. di Bursa Efek Indonesia antara tahun 2018 dan 2021. Sampling purposive digunakan untuk mengumpuIkan data dari totaI 232 bisnis seIama empat tahun. Menggunakan SPSS 23, metode anaIisis regresi Iogistik dikembangkan. VariabeI komite audit dan posisi keuangan perusahaan sama-sama berkontribusi pada tren peningkatan kemungkinan opini audit keIangsungan hidup, seperti yang ditunjukkan oIeh pengujian. Di sisi Iain, peniIaian keIangsungan audit dipengaruhi secara negatif oIeh ukuran perusahaan. Temuan peneIitian ini dapat memandu investor daIam meIakukan pembeIian yang bijak, dan mereka harus berhati-hati saat membeIi saham di perusahaan yang berkembang pesat.
PENGARUH PROFITABILITAS (ROE), KEPEMILIKAN MANAJERIAL, KUALITAS AUDIT, KOMITE AUDIT DAN UKURAN PERUSAHAAN TERHADAP TAX AVOIDANCE PADA PERUSAHAAN MANUFAKTUR SUBSEKTOR MAKANAN DAN MINUMAN
Authors: Lapian Lutfia larasanti , Aqamal Haq
Published: April 2023

Observasi berikut dilakukan demi pemenuhan evaluasi Pengaruh Profitabilitas, Kepemilikan Manajerial, Kualitas Audit, Perutusan Pemeriksa, serta Skala Perusahaan terhadap perwujudan penghindaran pajak pada lingkup korporasi subsektor agrikultur pangan yang termuat dalam pasar uang tahun 2017-2021. Prosedur penetapan spesimen memakai metode purposive sampling dan terkumpul 70 data, Observasi ini memanfaatkan prosedur kajian degenerasi dengan dukungan program SPSS.
PENGARUH MANAJEMEN LABA MELALUI AKRUAL DISKRESIONER TERHADAP NILAI RELEVANSI INFORMASI AKUNTANSI PADA PERUSAHAAN MANUFAKTUR
Authors: Agatha Susanti Florencia , Titik Aryati
Published: April 2023

Penelitian ini bertujuan untuk menguji dan menganalisa pengaruh manajemen laba yang melalui proses diskresioner akrual terhadap nilai relevansi informasi akuntansi yang di proxykan oleh harga saham dan return saham dengan nilai laba dan nilai buku sebagai variabel kontrol. Data yang yang digunakan dalam penelitian ini adalah data sekunder, yaitu dari laporan keuangan dan laporan tahunan, dengan populasi penelitian yaitu perusahaan manufaktur sektor barang konsumsi yang terdaftar di Bursa Efek Indonesia periode 2018 hingga 2020. Teknik pengambilan sampel yang digunakan adalah purposive sampling, sehingga diperoleh 87 perusahaan yang digunakan sebagai sampel pada penelitian ini. Metode yang digunakan dalam penelitian ini adalah analisis regresi linear berganda. Hasil analisis penelitian ini menunjukkan bahwa nilai laba berpengaruh terhadap harga saham tetapi nilai laba tidak memiliki pengaruh terhadap return saham. Hasil berikutnya menunjukkan bahwa nilai buku tidak memiliki pengaruh terhadap harga saham, sebaliknya nilai buku memiliki pengaruh terhadap return saham.
PENGARUH ECONOMIC VALUE ADDED & MARKET VALUE ADDED TERHADAP RETURN SAHAM STUDI PADA PERUSAHAAN YANG TERDAFTAR DALAM INDEKS INFOBANK15 TAHUN 2017 - 2021
Authors: Salman Ayub , Aqamal Haq
Published: April 2023

Penelitian ini bertujuan untuk menguji secara empiris pengaruh economic value added dan market value added terhadap return saham pada perusahaan perbankan yang tergabung dalam indeks infobank 15 Periode waktu yang digunakan pada penelitian ini yaitu mulai tahun 2017–2021. Penelitian ini dilakukan dengan menggunakan metode penelitian kuantitatif dengan pengujian hipotesis untuk menjelaskan pengaruh antar variabel. Penentuan sampel dalam penelitian ini diperoleh dengan metode purposive sampling. Berdasarkan kriteria yang telah ditentukan, didapatkan 10 perusahaan yang menjadi sampel penelitian. Teknik analisis data yang digunakan adalah regresi linier berganda. Hasil penelitian menunjukkan bahwa economic value added berpengaruh positif dan signifikan terhadap return saham. Sedangkan market value added tidak berpengaruh terhadap return saham.
PENGARUH AUDIT TENURE, LIKUIDITAS, PROFITABILITAS DAN OPINI AUDIT TERHADAP OPINI GOING CONCERN PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Rahmania Chintia Ayu , Amir Faizal
Published: April 2023

Tujuan dari penelitian ini untuk menyelidiki pengaruh Opini Audit, Likuiditas, Profitabilitas, Audit Tenure terhadap Opini Going Concern. Sampel yang digunakan ialah perusahaan manufaktur sektor industry konsumsi yang terdaftar di Bursa Efek Indonesia tahun 2018 – 2021. Purposive sampling digunakan sebagai metode pemilihan sampel. Kesimpulan dari penelitian ini adalah hasil pengujian laporan auditor tidak mempengaruhi pernyataan perusahaan, hasil pengujian likuiditas berpengaruh negatif terhadap pernyataan perusahaan, hasil pengujian tenur auditor berpengaruh negatif terhadap pernyataan perusahaan, hasil pengujian profitabilitas tidak mempengaruhi pernyataan perusahaan. Implikasi dari penelitian ini diharapkan menjadi bahan pertimbangan bagi perusahaan dan diharapkan menjadi bahan pertimbangan dan referensi bagi penelitian selanjutnya.
PENGARUH PROFITABILITAS LIKUIDITAS KEPUTUSAN INVESTASI DAN KEPUTUSAN PENDANAAN TERHADAP NILAI PERUSAHAAN
Authors: Sari Mai Lita , Juniati Gunawan
Published: April 2023

Nilai Perusahaan merupakan salah satu indikator penilaian kinerja perusahaan untuk membantu perusahaan dalam melakukan kegiatan investasi dan merupakan kondisi yang menggambarkan pencapaian suatu perusahaan selama proses beroperasinya. Penelitian ini bertujuan untuk menguji pengaruh Profitabilitas, Likuiditas, Keputusan Investasi dan Keputusan Pendanaan terhadap nilai perusahaan. Populasi dalam penelitian ini adalah perusahaan sektor Properti & Real Estate dan Konstruksi & Teknik Sipil yang tercatat di Bursa Efek Indonesia periode 2019-2021. Teknik pengambilan sampel yang digunakan adalah purposive sampling yaitu metode pengambilan sampel penelitian menggunakan kriteria-kriteria yang telah ditetapkan. Tercatat sebanyak 88 perusahaan di Bursa Efek Indonesia periode 2019-2021 dan terpilih sebanyak 59 perusahaan yang memenuhi kriteria sampel penelitian dengan periode pengamatan selama 3 tahun sehingga diperoleh sebanyak 177 data sampel. Metode analisis data yang digunakan dalam penelitian ini adalah regresi data panel dengan menggunakan perangkat lunak Eviews versi 12. Hasil penelitian memberikan simpulan bahwa variabel profitabilitas (ROE), Likuiditas (CR), Keputusan Investasi (TAG) dan Keputusan Pendanaan (DER) berpengaruh positif terhadap Nilai Perusahaan (Tobin’s Q).
PENGARUH PROFITABILITAS, LEVERAGE, CAPITAL INTENSITY, DAN INVENTORY INTENSITY TERHADAP TAX AVOIDANCE PADA PERUSAHAAN MANUFAKTUR SEKTOR INDUSTRI BARANG KONSUMSI YANG TERDAFTAR DI BEI TAHUN 2018-2020
Authors: Nursari Dwi Martia , Nazir Nazmel
Published: April 2023

Tujuan penelitian ini untuk menguji pengaruh profitabilitas, leverage, capital intensity, dan inventory intensity terhadap tax avoidance pada perusahaan manufaktur sektor industri barang konsumsi yang tercatat dalam Bursa Efek Indonesia (BEI). Data yang digunakan dalam penelitian ini ialah data perusahaan yang terdaftar dalam BEI pada tahun 2018 – 2020. Jumlah sampel penelitian ini ialah sebanyak 24 perusahaan yang diamati selama 3 tahun, dengan demikian keseluruhan sampel penelitian sebanyak 72 data perusahaan yang dipilih dengan menggunakan metode purposive sampling. Penggunaan metode dalam menganalisis hubungan antar variabel ialah dengan analisis regresi berganda menggunakan alat analisis SPSS (Statiscal Package for Social Sciences). Berdasar pada hasil penelitian, peneliti menyimpulkan bahwa: (1) Profitabilitas mempengaruhi tax avoidance (2) Leverage mempengaruhi tax avoidance (3) Capital intensity tidak mempengaruhi tax avoidance (4) Inventory intensity mempengaruhi tax avoidance
PENGARUH SISTEM INFORMASI AKUNTAN TERHADAP PENGAMBILAN KEPUTUSAN MANAJEMEN PADA PT. NEID
Authors: Hakim Anaz , Sudarmadji Herry Sutrisno
Published: April 2023

Sistem informasi akuntansi sudah menjadi salah satu bagian vital dalam operasional suatu perusahaan agar lebih cepat dalam mengambil suatu keputusan dari laporan yang di hasilkan dari system informasi tersebut. Dalam penelitian ini, peneliti menjadikan PT.NEID sebagai tempat studi dan menggunakan pendekatan deskriptif kualitatif  untuk menghimpun data yang dibutuhkan dalam penelitian, PT.NEID merupakan perusahaan forwader dalam kegiatan operasional nya membutuhkan system informasi akuntasi untuk mendukung kegiatan perusahaan saat pencatatan transaksi keuangan yang juga akan menghasilkan sebuah laporan keuangan yang akan dibutuhkan perusahaan.Dalam kegiatan operasional nya PT.NEID menggunakan sistem informasi akuntan yaitu aplikasi SAP Dan sistem informasi yang sudah terkomputerisasi, relevan, dan terstandarisasi. Sistem informasi akuntansi akan membantu perusahaan dalam mengelola keuangan secara lebih efisien dan tepat. Sistem informasi akuntansi menghasilkan data yang membantu manajemen dalam pengambilan keputusan.
PENGARUH FINANCIAL DISTRESS DAN REAL ACTIVITY MANIPULATION TERHADAP PEMBERIAN OPINI AUDIT GOING CONCERN DENGAN PROFITABILITAS SEBAGAI VARIABEL MODERASI
Authors: Putri Saskia , Sri Lastanti Hexana
Published: April 2023

Penelitian ini memiliki tujuan untuk menganalisis pengaruh Financial Distress dan Real Activity Manipulation dengan proksi Abnormal Cash Flow from Operating dan Abnormal Discretionary Expense terhadap pemberian Opini Audit Going Concern oleh auditor dalam melakukan penilaian audit, dengan profitabilitas sebagai variabel moderasi. Data yang diambil dalam penelitian ini adalah perusahaan sub sektor pariwisata, hotel, dan restoran yang terdaftar di Bursa Efek Indonesia tahun 2019-2021. Sampel yang digunakan adalah sebanyak 35 perusahaan dengan total 105 sampel, pengambilan sampel deilakukan dengan metode purposive sampling. Metode yang digunakan dalam penelitian ini adalah Binary Logistic Regression. Hasil dari penelitian yang telah dilakukan menunjukkan bahwa, variabel Financial Distress berpengaruh positif terhadap pemberian Opini Audit Going Concern, sementara variabel Real Activity Manipulation yang diproksikan dengan Abnormal Cash Flow from Operating tidak berpengaruh terhadap pemberian Opini Audit Going Concern, namun dengan proksi Abnormal Discretionary Expense berpengaruh negatif terhadap pemberian Opini Audit Going Concern. Variabel Profitabilitas tidak mampu memoderasi pengaruh positif Financial Distress, variabel proksi Real Activity Manipulation, yaitu Abnormal Cash Flow from Operating dan Abnormal Discretionary Expense terhadap pemberian Opini Audit Going Concern. Hasil dari penelitian ini bertujuan sebagai bantuan informasi bagi auditor untuk dapat memperhatikan aspek-aspek yang diteliti untuk memberikan opini audit keberlanjutan.
The Problem of Language Insecurity of Azerbaijani School Graduates Living in Russia: Methods of Overcoming it
Authors: Hasanov Mammadali Magsad Ogly
Published: April 2023

The object of the study is the linguistic uncertainty of Azerbaijanis who live in Russia. The subject of the study is the causes of the phenomenon of language insecurity among graduates of Azerbaijani schools who received education in Russian in Azerbaijan, as well as the main reasons of a social and individual nature that contribute to its manifestation. The article describes the main reasons that have become the source of language insecurity among graduates of Azerbaijani schools who have received general secondary education in Russian in Azerbaijan. The authors of the article investigated the existing methods of teaching Russian in schools in Azerbaijan, the main problems that arise during the teaching of students, as well as obstacles that may affect the process of formation of language skills and knowledge of students. In order to study the causes of language insecurity among graduates of Azerbaijani schools in the course of communication while in the Russian Federation, we conducted a series of interviews with graduates of a number of schools in the capital of the country, in the city of Baku. The definition of the concept of language insecurity is given and the main reasons of both social and individual nature are shown, contributing to the manifestation of language insecurity in a number of students who have graduated from Azerbaijani schools with the Russian language of instruction.
CONCEPTS OF UNIVERSAL TIME AND MULTIPLICITY OF TIMES IN UNDERSTANDING THE EXISTENCE OF PAST REALITY
Authors:   Orenburg State Pedagogical University, Orenburg, Russia, Shcherbakov D. A.
Published: April 2023

Abstract. The purpose of the article is to identify and determine the dependence of ontological ideas about the existence of past reality on thinking within the framework of competing concepts of universal time and multiplicity of times. The methods of research were the representation, comparison and ontological analysis of various ideas about the essence and nature of time, synthesis and philosophical criticism of the consequences arising from competing concepts of the multiplicity of times and the concept of a single universal time in relation to the definition of ontological characteristics of past reality. The article gives a representation of several versions of the concepts of multiplicity of times, some of which are based on the theory of relativity, others proceed from ontological differences in the processes of various forms of being — being material, spiritual, personal and social. It has been shown that in some cases, in the concepts of multiplicity of times, time itself and the idea of time as a construct of the mind are mistakenly identified, which serves as the reason for the incorrect attribution of time to atypical paradoxical properties, such as inversion — the possibility of its movement to reverse, the uncertainty of the past, present and future, the variability of the past and others. The author gives critical arguments refuting ideas about the possibility of changing the places of events and states of reality in the time relationship “earlier/later,” that is, in the sequence of their appearance and disappearance, as well as incorrect opinions about the possibility of variability of the past under the influence of processes that take place in the present and have to be in the future. The study justifies the idea that a clear and unambiguous distinction between past and present objective reality is impossible from the point of view of ideas about the multiplicity of times and is possible only in the conceptual field of theories, recognizing the unity of the world and using a single scale of universal time common to processes and events, having different ontological characteristics and flowing in arbitrarily distant places of space in different inertial reference systems.
METHODOLOGY FOR SELECTING THE TYPE OF BATTERY FOR OPERATION OF ELECTRIC VEHICLES IN COLD REGIONS
Authors:   Saint Petersburg State University of Architecture and Civil Engineering, Saint Petersburg, Russia, Terentiev E. E. , Blyankinshtein I. M. ,   Saint Petersburg State University of Architecture and Civil Engineering, Saint Petersburg, Russia
Published: April 2023

Abstract. The issue of evaluating the efficiency of high-voltage batteries of electrified vehicles at low temperatures is considered. A technique is presented for selecting the electrochemical type of batteries for operation in regions with a cold climate, which includes experimental obtaining of the charge-discharge characteristics of high-voltage batteries under conditions of normal and low temperatures and their analytical study. As a result of testing the methodology, regression dependences were obtained that describe the processes of charge-discharge of batteries of various electrochemical types (Li-Ion, LiFePO4, LTO) as a function of temperature. In connection with the emergence of new electrochemical types of batteries with increased resistance to hypothermia, the proposed method will allow us to evaluate their effectiveness and fully use electric cars in regions with a cold climate. The purpose of the study is to develop a methodology for selecting batteries for low-temperature operation of electric vehicles and hybrids based on an experimental study and comparison of results. The method used is mathematical planning of the experiment, correlation-regression analysis of experimental data with the construction of mathematical models of charge-discharge. Main results — a method for choosing an electrochemical type of battery for operation in regions with a cold climate was developed and tested. The novelty of the study is represented by mathematical models that describe the change in the capacity of high-voltage batteries depending on temperature. The direction of further research is the refinement of models, the study of the low-temperature properties of new and promising types of chemical elements of high-voltage batteries.
Development of Size Optimized Bromelain Loaded Nanocarriers by Box- Behnken Design
Authors: George Anit J , Saju Fels , Mishra Bharat
Published: April 2023

Bromelain (BRN) is an extensive product of investigation, regarded as eff ective naturally produced anticancer agents. Heterogeneity of tumors amongst patients and within disease, generates a necessity of personalization of nanomedicine. The size of nanoparticle is found to be a signifi cant target in enhancing precision therapeutics, by fondly accumulate it within the tumor microenvironment. The objective of the study is to achieve an optimum size of 50 to 100 nm BRN loaded nano carriers, to intensify the EPR eff ect and thereby overcome heterogeneity. Optimization of the nanoparticles commenced with the interrogation of eff ect by various formulation variables. The development of nanoparticles carried out by the nanoprecipitation method, where three independent variables, such as the amount of PLGA, Tween 80 and BRN are chosen after an overall screening and employed in Design Expert Software. The selected Box-Behnken design provides a total of 17 confi rmatory runs at varied levels of independent variables and detected its infl uence on responses. The runs resulted in an optimized formula with the desired particle size of 78.64 ± 2.14 nm and a maximum entrapment effi ciency of 89.14% at 24th hour. Then the selected formula characterized for polydispersity index, zeta potential, sanning electron m icroscopy, determination of drug content, study of in-vitro drug release etc.
A Comparative Study of Concentration of Growth Factors in Lyophilized PRP with Fresh PRP at Diff erent Storage Conditions
Authors: Vyas Pooja U , Khobragade Deepak S , Mundhada Dharmendra R , Shrivastava Sandeep P , Vyas Ujwal B , Pethe Anil M
Published: April 2023

Background: There is ongoing debate regarding platelet-rich plasma’s (PRP) ability to eff ectively heal soft tissue injuries. Lyophilized platelet-rich plasma (L-PRP) was created and kept using the blood bank’s standard separation procedures. The objective of study was to evaluate eff ects of lyophilization on PRP and its properties such as level of growth factors. Also, the eff ect of storage conditions on growth factors. Methods: The PRPs were created through a two-step centrifugation process and lyophilized. After freeze-thawing to allow platelet growth factors to be released, levels of hepatocyte growth factor (HGF), transforming growth factor (TGF), fi broblast growth factor (FGF)-basic, platelet-derived growth factor (PDGF)-AB, insulin-like growth factor (IGF)-1, and vascular endothelial growth factor (VEGF) were measured each day during storage. Results: After L-PRP preparation, levels of FGF-basic, VEGF, PDGF-AB, EGF and TGF- beta1 signifi cantly raised and levels of HGF and IGF-1 in L-PRPs had light rise. Conclusions: In comparison to F-PRP, platelet counts and seven growth factors increased during preservation in L-PRP. PRPs that have been stored may be injected several times using our method. L-PRP was effi cacious and stable for 90 days when stored at 8oC.
The Protective Eff ects Trimetazidine on Indomethacin Induced Gastric Ulcer in Rat Model
Authors: Imad Redhaa , Al-Qadh Huda I
Published: April 2023

Introduction: Gastric ulcer (GU) is the most common gastrointestinal tract disorder, representing about 20% of peptic ulcer due to an imbalance between gastric defense mechanisms and aggressive factors, mainly Helicobacter pylori and non-steroidal anti-infl ammatory drugs (NSAIDs). The study aims to evaluate trimetazidine’s protective eff ect on histopathology, GU severity, infl ammatory and oxidative stress markers (TNF- alpha, MPO and MDA) in rate model of indomethacin induced GU. Method: Total 30 healthy male albino rats were divided into fi ve groups each of ten (N=10). Group A: Given indomethacin vehicles (normal saline 0.9% and tween 80) orally via gavage tube and serve as control positive group. Group B: Induced ulcer by Indomethacin 60 mg/kg orally via oral gavage serve as control negative. Group C: Pretreated with trimetazidine 50 mg/ kg orally by gavage tube 1-hour before administering indomethacin 60 mg/kg. At the end of study histological examination, anti-infl ammatory and antioxidant markers were evaluated. Results: TMZ 50 mg/kg pretreated groups show a signifi cant (p 0.01) reduction in GU severity score and histopathology damage score in comparison with the indomethacin ulcerated group. Moreover, pretreated groups TMZ 50 mg/kg showed a signifi cant reduction in infl ammatory markers (TNF-alpha and MPO) and oxidative stress marker (MDA) in comparison with the induction group, similar to the results of the reference drug. Conclusion: TMZ dihydrochloride has similar effi cacy as standard omeprazole drug by a decrease in oxidative stress status manifested by a reduction in lipid peroxidation indicator marker and a reduction in pro-infl ammatory cytokine level and leukocyte recruitment indicator marker and fi nally, macroscopic and microscopic evaluation show a reduction GU severity.
Pharmacobotanical Application of Ricinus communis Seed Oil in Formulation and Evaluation of Herbal Emulgel for the Treatment of Psoriasis
Authors: Pathare Sujit , Babar Snehal , Tare Manoj , Baheti Dwarkadas , Tare Harshal , Deshmukh Nitin , Sable Vijay
Published: April 2023

Infl ammatory and immune-mediated skin disease, psoriasis. It’s common for psoriasis to be seen in people all over the globe. Drugs are most eff ectively delivered through the topical route for treating skin conditions. An attempt was made to increase the eff ectiveness of topical treatment for psoriasis by using emulgel compositions containing Ricinus communis seed oil. In order to create the gel, the extract was mixed with liquid paraffi n, olive and coconut oils, and Carbopol 936 and 940 gelling agents. The viscosity and glossiness of the emulgel were achieved using herbal extracts. When tested for physicochemical criteria, the developed formulations were found to be acceptable in every way. These fi ndings imply that topical gel therapy for psoriasis is becoming more eff ective. Due to the emulgel improved penetration, the herbal gel has more eff ectiveness.
Phytochemical Screening by GC/MS with Isolation and Characterization of ß-sitosterol and Stigmasterol from Iraqi Euonymus japonicus L. Leaves Parts by Diff erent Techniques
Authors: Khalaf RusulRasha A , Abdul-Jalill Thukaa Z
Published: April 2023

Euonymus japonicus L., often known as the spindle tree, is a Celastraceae family plant utilized in traditional medicine and as an attractive garden plant. The goal of this study was to identify and isolate the active compounds B-sitasterol and stigmasterol from the roots and leaves of E. japonicus by using gas chromatography/mass spectrometry (GC-MS), high performance liquid chromatography (HPLC), and reverse phase-high performance liquid chromatography (RP-HPLC) were used to investigate the chemical composition of the leaves and root of E. japonicus. This confi rms the presence of b-sitosterol and stigmasterol in the leaves and roots of E. japonicus L. plant. The structure of these chemicals was clearly defi ned by UV spectroscopic, FTIR spectroscopic, and TLC techniques, revealing similarity to B-sitosterol and stigmasterol
In-vitro Anticancer Activity of Various Plant Extracts
Authors: Mishra Sagar K , Dash Sribatsa L , Mohapatra Ranjit
Published: April 2023

Herbal medicinal plants have been explored for a variety of pharmacological properties but still a large number of phytoconstituents are still unexplored. The manuscript aims to assess the anticancer property of Leucas cephalotes (Roth) Spreng, Acalypha indica L. and Lantana camara L. extracts on MDA-MB-231, A-549, PC-3 and Hep-G2 cell lines. The ethanol extract of the selected plants was explored for anticancer activity by SRB assay. Since L. camara exhibited promising activity, this plant’s successive extraction in diff erent extracts (n-hexane, chloroform, ethanol and hydroalcoholic) was further studied. All the extracts were screened for anticancer activity by SRB assay on MDA-MB-231 and A-549 cell lines. Additionally, the apoptotic assay was carried out on n-hexane and chloroform extracts on A-549 cell lines. GCMS also analyzed both extracts for characterization of the phytoconstituents. Obtained data indicate that n-Hexane and chloroform extracts of L. camara showed promising anticancer activity on MDA-MB-231 and A-549 cell lines. Both extracts also induced apoptosis in A-549 cell line. GC-MS data of L. camara extracts revealed the presence of 25 and 19 compounds in n-hexane and chloroform extract, respectively. The present study shows that L. camara has strong anticancer properties against lung cancer cell lines compared to breast, prostate, and hepatoma cancer cell lines
Eff ects of Non-standard Storage Conditions on the Stability, Safety and Suitability of Drug Consumption
Authors: . Alsammarraie , Mahdi Harith J
Published: April 2023

Drugs are distinctive and sensitive products. It should pass specifi c tests and have specifi c criteria for human use. The disparity of any of the acceptance criteria will infl uence the product’s eff ectiveness, despite the product being still in validated expiry date. The stability study and manufacturing of many drugs were done at specifi c climatic zones, but marketed and sold at diff erent climatic zones. In a hot poor country or country that suff ers from a power supply shortage (like in Iraq), it is impossible to provide standard storage conditions as the manufacturer recommends. The research aims to study the eff ects of nonstandard storage conditions on the offi cial and non-offi cial acceptance criteria for stored tablets compared to the same newly manufactured tablets. The results showed that the physical appearance, tablet hardness, friability, disintegration, uniformity of weight, assay was not aff ected. On the other hand, the dissolution profi le of the stored products showed a change in the solubility behavior. From the results, we can conclude that storage conditions may not aff ect the content of the active substance. Still, it may aff ect other characteristics of the active substance, such as solubility. The research recommends the necessity of scrutiny of the storage conditions of drugs and not being lenient with them. Also recommends the necessity to study the dissolution profi le and stability of excipients when conducting a drug stability study and determining the expiry date.
Preclinical Evaluation of Effi cacy of Processed PRP and Fresh PRP in Diabetic Wound Healing
Authors: U Vyas Pooja , S Khobragade Deepak , R Mundhada Dharmendra , P Shrivastava Sandeep , B MundhadaVyas Ujwal , M Pethe Anil
Published: April 2023

Background: One in four people with diabetes will experience diabetic wounds at some point in their lifespan, which is among the diabetes complications that have the worst eff ects on quality of life. The study’s objective was a comparative preclinical study of the effi cacy of fresh platelet-rich plasma (PRP) Vs L-PRP in diabetic wound. Methods: Twenty four rabbits were used to study the effi cacy. Diabetes was generated in the rabbits, and the diabetic wound’s perilesional region received PRP treatment. The comparative evaluation by done by counting the wound area and rate of healing. Results: There was more than three folds rise in growth factors in lyophillised-PRP than compared to fresh PRP. The rate of wound healing was much fast in lyophilised PRP group. In the control group the wound was unhealed by 30th day and also showed pus cell formation and symptoms of infection. However, it was completely healed on 25th day when treated with L-PRP stored at 8℃. Conclusion: The outcomes prompted clinical research to compare L-PRP to fresh PRP’s effi cacy.
Comparative Extraction and Quantifi cation of Myricetin from Leaves of Madhuca longifolia Using RP-HPLC
Authors: Kendre Nutan , Wakte Pravin
Published: April 2023

Background: This study’s purpose was to develop a sensitive, repeatable reverse-phase high-performance liquid chromatography (RP-HPLC) method for extracting the main fl avonoid Myricetin from the leaves of Madhuca longifolia and quantifying it. Materials and Methods: Diff erent leaves extracts were prepared using various solvent systems, including ethanol, ethanol: water (50:50), and water, through various extraction methodologies, including hot and cold maceration and soxhlet-assisted extraction, in order to optimize the best solvent system and ideal extraction methodology (SAE). Myricetin was separated by chromatography using a C18 column. Results: According to the fi ndings, the hydroalcoholic extract had the greatest content of myricetin at 2.524 ng. This study reports the presence of fl avonoid content in M. longifolia leaves extract that can be extracted using, water:ethanol and ethanol. The best solvent system was water:ethanol, and the best extraction technique was cold maceration. Conclusion: M. longifolia extracts were produced by hot and cold maceration, SAE techniques, and their fl avonoid concentrations were measured using HPLC-ESI-MS/MS. Water: Cold maceration and ethanol were shown to be promising solvent systems. While trying to extract myricetin from M. longifolia leaves, the extraction approach was more eff ective than other traditional extraction methods.
The Role of Ketogenic Diet in the Management of Diabetes and Overcome it’s Eff ect: A Review
Authors: . Versha , Jangra Yashika , Sharma Luxita , Meher Abhishek , Tare Harshal
Published: April 2023

The ketogenic diet, which is low in carbohydrates, may help diabetic people reduce their medication and improve their glycemia. Obesity and diabetes are two of the most well-known metabolic diseases connected with unfortunate dietary patterns and a stationary way of life. In the direst outcome imaginable, metabolic issues are a contributing reason to a wide range of diseases. The ketogenic diet replaces glucose with ketone bodies and is useful in various conditions, including metabolic disorders, epileptic seizures, peripheral neuropathy, kidney cancer, and skeletal muscle atrophy. Obesity is connected to a higher risk of type two diabetes. In obese people with glucose intolerance, it has been discovered that successful weight management and dietary adjustments, particularly in terms of carbohydrate content and glycemic index, have favorable benefi ts. We’ve already demonstrated that a ketogenic diet could help you to lose weight. Furthermore, even in hyperlipidemic obese people, it improves cardiac risk factors. For a period of 56 weeks, the eff ect of low carbs or ketogenic diet was evaluated in patients having obesity with high glucose levels of blood to those with moderate blood glucose levels in this study. In many circumstances, excess insulin treatment and protein limitation slow the onset of diabetic nephropathy, and very few therapies are known to reverse nephropathy. The Keto diet regulates glucose and insulin levels in the body, making it an effi cient diabetes treatment. As a result, the keto diet can be used to demonstrate the gap between diabetes treatment and obesity. Obesity is connected to a higher risk diabetes of type 2. In obese people with glucose intolerance, it has been discovered that successful weight management and dietary adjustments, particularly in carbohydrate content and glycemic index, have favorable eff ects. Diabetic nephropathy was entirely restored after two months of following a ketogenic diet, as measured by albumin/creatinine ratios and stress-induced gene expression. On the other hand, histological evidence of nephropathy was only partially reversed. This shows that diabetic nephropathy can be restored with a relatively straightforward dietary change. It’s still unclear if the ketogenic diet’s benefi cial eff ects are mediated by lower glucose metabolism. Glycemic levels are aff ected by dietary changes. The low-carb ketogenic diet was found to be quite promising in managing diabetic mellitus in preliminary investigations.
The first experience of transscleral laser thermotherapy of retinoblastoma
Authors:   S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Yarovoy A.A. , Volodin D.P. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Loginov R.A. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation
Published: April 2023

Purpose. To evaluate the efficacy of transscleral thermotherapy (TSTT) in eight patients with retinoblastoma (Rb). Material and methods. In total, 8 patients (9 eyes, 22 tumors) with Rb were treated by TSTT. The average age at the time of treatment was 28 months (from 10 to 45 months). Bilateral Rb was observed in six patients, unilateral – in two. All tumors had preequatorial localization (7 foci – on the mid periphery and 15 – on the far periphery of the fundus). The number of tumors in one eye varied from 1 to 6. The mean tumor thickness was 0.7 mm (from 0.5 to 1.4), the mean basal diameter was 1.5 mm (from 1.0 to 2.9). TSTT was performed transconjunctivally using a diode laser with the following parameters: wavelength – 810 nm, spot diameter – 1000 microns, power from 200 to 500 MW (average – 350 MW), exposure – from 3 to 15 seconds in the scanning mode. Results. Complete tumor regression after TSTT was achieved in 86% of cases (19 tumors). In one case (5%) an incomplete tumor regression was observed and transpupillary thermotherapy was performed. In two cases (9%) continued tumor growth occurred, which required the use of cryotherapy. Overall local tumor control was achieved in all cases (22 tumors). All eyes are preserved, all patients included in the study are alive without distant metastases. No complications from both the anterior and posterior segments, as well as visual signs of scleral damage were not observed in any case. The follow–up period after TSTT ranged from 3 to 11 months (mean – 6 months). Conclusion. First experience of TSTT showed that this method is very promising and can be used to treat small Rb of preequatorial localization in the absence of risk of damage to the iris and equator of the lens, which is the benefit of TSTT compared to transpupillary thermotherapy. Key words: retinoblastoma, transcleral thermotherapy, laser treatment, preequatorial localization, small tumors
Comparative analysis of surgical treatment of rhegmatogenous retinal detachment with lower localization of breaks with tamponade of the vitreal cavity by gas or silicone
Authors:   S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Shpak A.A. , Shkvorchenko D.O. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Gorshkov I.M. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Yukhananova A.V. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation
Published: April 2023

Purpose. To perform a comparative evaluation of the efficacy and functional results of surgical treatment of rhegmatogenous retinal detachment (RRD) with breaks in the lower hemisphere using gas or silicone tamponade of the vitreal cavity. Material and methods. Seventy-eight patients (78 eyes) with RRD and the location of breaks in the lower hemisphere were examined. Depending on the nature of retinal detachment patients were divided into 2 groups: without macular detachment («Macula-on») – 36 patients (36 eyes) and with retinal detachment in the macular area («Macula-off») – 42 patients (42 eyes). Each group included two subgroups «Gas» and «Silicone» depending on the type of final vitreal tamponade performed with gas (12% gas-air mixture with perfluoropropane C3F8 ) or silicone (Densiron), respectively. The type of tamponade was chosen randomly. Results. Subgroups of patients with different types of tamponade did not differ from each other in clinical and demographic characteristics. In the postoperative period, a complete retinal attachment was achieved in 75 patients (96%). At 6 months postoperatively, retinal light sensitivity (total and in central point) in the Macula-on group was significantly higher after treatment with gas tamponade compared to the final tamponade with silicone. For other parameters in the Macula-on group, the type of tamponade did not play a significant role. In the Macula-off group, neither functional parameters nor optical coherence tomography data at 6 months depended on the type of tamponade. Conclusion. The use of tamponade with an air-gas mixture and silicone in RRD patients with localization of breaks in the lower hemisphere is equally effective in achieving a high frequency of retinal attachment. Patients with RRD without macular involvement had significantly higher retinal light sensitivity (total and in central point) after treatment with gas-air tamponade compared to final tamponade with silicone. Gas-air tamponade has the advantage of not requiring a second surgical intervention and can be recommended for wide use in RRD patients with breaks in the lower hemisphere without significant proliferative vitreoretinopathy. Key words: rhegmatogenous retinal detachment, inferior hemisphere break, gas tamponade, silicone tamponade, photosensitivity
Evaluation of the long-term outcomes of surgery of submacular hemorrhage in patients with exudative age-related macular degeneration
Authors:   S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation, Rudenko V.A. , Khudyakov A.Y. ,   S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation, Kolenko O.V. ,   S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation,   Postgraduate Institute for Public Health Specialists, Khabarovsk, Russian Federation,   Far-Eastern State Medical University, Khabarovsk, Russian Federation, Sorokin E.L. ,   S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation,   Far-Eastern State Medical University, Khabarovsk, Russian Federation
Published: April 2023

Purpose. To evaluate the long-term outcomes of surgery of submacular hemorrhage (SMH) in patients with exudative age-related macular degeneration. Material and methods. A dynamic follow-up of 32 patients with SMH (32 eyes) was carried out, who underwent 25G endovitreal intervention with subretinal injection of 1000 to 3000 IU of the Gemaza drug. The area of the SMH in all cases was extensive with the capture of the fovea. The follow-up period ranged from 24 to 30 months. Results. There was displacement of almost the entire volume of SMH from the macular area to the low periphery in all operated eyes by the next day after the operation. There were complete elimination of SMH and the formation of a normal configuration of the macular profile in 7 days after surgery in all eyes. All patients were satisfied with the results of the surgery according to significant increase of visual acuity and disappearance of a spot in the central visual field. Postoperative complications appeared in four eyes at different times of follow up period, but they were eliminated after reoperation. Conclusion. Subretinal administration of the drug Gemaza and pneumodislocation of the blood clot is an effective method for the treatment of SMH with a limitation period of up to 2 weeks. In the vast majority of cases (88%), it was possible to achieve complete elimination of the SMH and a significant improvement in central vision. Key words: submacular hemorrhage, Gemaza, recombinant prourokinase, age-related macular degeneration, subretinal neovascular membrane