bluuebunny/crossref_metadata_2025 huggingface dataset:
Modelo Alternativo De Funcionamiento Del Sistema Turístico: Teoría De Enjambres Del Turismo Mundial
Authors: Zaquinaula Manuel Antonio Abarca
Published: October 2017

The present theory was developed based on the alternative model of operation of the tourist system proposed by the author (based on the models of Roberto Boullón, Neil Leiper, and OMT). It has to do,with a systemic-mechanical approach with harmonious, coordinated, and routine functioning among its four parts (governing body of the tourist system, real-potential demand, geographic space, and tourist offer). Also, it obtains greater efficiency and profitability during the course of its operation. This theory explains that the tourist development of the planet must be based on the correct functioning of the tourist systems of the world. To improve the effectiveness of the management of the global tourism, it must be structured as follows; World tourism = interconnection of tourist swarms, tourist swarms = entanglement of two or more supra tourist systems, supra tourist systems = link between two or more tourist molecules, tourist molecules = union of two compatible tourist systems. A tourist system, therefore, can be formed in any of these destination: a canton, province, region, country, and any other destinations that do not necessarily have political limits. This study explains how tourist molecules, supra tourist systems, and tourist swarms are formed. It highlights the importance of understanding, at the first instance, the alternative model of operation of the tourist system. This is because in its compression lies the basis of the effectiveness and development of global tourism.
High Trait Anger, Interpersonal Context, and the Recognition of Anger Problems
Authors: Alcazar-Olan Raul J. , Guzman Laura Hernandez , Perez Veronica Reyes , Fragoso Claudia Gonzalez , Rodriguez David Jimenez
Published: October 2017

Background: High trait anger is usually destructive for individuals and their relationships. This proneness to anger is reflected in frequent angry feelings, for longer periods of time, and with higher levels of physical arousal and negative expressions (e.g., insulting or arguing with others). Unfortunately, not all individuals with high trait anger recognize the problem. Objective: This research assessed the contribution of the interpersonal context (e.g., family members, friends, and boyfriend/girlfriend) to recognize anger problems. Methods: We recruited 192 individuals with high trait anger who completed questionnaires about 1) recognition of anger problems, 2) how they are perceived by others in terms of anger (i.e., “being irascible”), and 3) if they care about what others think about their anger. Research Design: Cross-sectional. Results: Individuals who recognized their anger problems perceived they have received more messages of “You are very irascible” from their social contexts, while those who do not recognize anger problems, have received these messages less often. Moreover, the higher the extent to which the individuals care about what other people think or say about their anger (i.e., higher importance attached to messages from others), the more it contributed to a higher recognition of anger problems. In addition, a lower importance attached to such messages was related to a lower recognition of such problems. Recognition of anger problems was higher in participants who had a boyfriend/girlfriend (versus those who did not have one), and in female (versus male) participants.
Análisis De Los Fundamentos Básicos Técnicos Del Baloncesto En El Rendimiento Deportivo De Los Estudiantes Categoría Intermedia Del Distrito Chambo - Riobamba
Authors: Brito Karolina Janeth Cando , Cayo Henry Rodolfo Gutierrez , Bravo Hernán Leopoldo Ponce , Arcos Helder Guillermo Aldas , Moreno Orlando David Mazón
Published: October 2017

This research was carried out on student’s athletes of Circuito Educativo 06D01C02 Riobamba-Chambo, in Chimborazo province district. The main objective of this study is to know the basic technical fundamentals of basketball in the performance of students of the intermediate category. This however would be used to determine specifically the basics technical basis. It would also help to define the level of the basic technical fundamentals in order to make a proposal. The elaboration of a training plan is aimed at developing the technical basis for the intermediate category. Within the methodology, it is a quantitative and qualitative research. This is a field research because it will run in the scene where practical assessments will be applied to each one of the students. Additionally, it will be a documentary bibliographical mode. It will be exploratory and correlational, and would take into account the population and sample which comprises of 6 coaches, 10 monitors, and 75 students of the category. The sample was under direct observation technique. As an instrument, the survey and a closed questionnaire was applied. Later on, the processing and tabulation alternative hypothesis was accepted. It was expressed as conclusions that the basic technical foundations in this category are determined by the work of dribbling, shooting ring tray, chest pass, and defense as predominant elements. It appears that the level of the basic technical fundamentals on student is regular, which is due to inadequate training and poor methods in the teaching process.
Analytical solutions of the relative orbital motion in unperturbed and in J
2 - perturbed elliptic orbits
Authors: El-Shaboury S. M. , Ammar M.K. , Yousef W.M.
Published: October 2017

This paper introduces a different approach to obtain the exact solution of the relative equations of motion of a deputy (follower) satellite with respect to a chief (leader) satellite that both rotate about central body (Earth) in elliptic orbits by using Laplace transformation. Moreover, the paper will take the perturbation due to the oblateness of the Earth into consideration and simulate this problem with numerical example showing the effect of the perturbation on the Keplerian motion. The solution of such equations in this work is represented in terms of the eccentricity of the chief orbit and its true anomaly as the independent variable.
Acetabular Reconstructions with Impaction Bone-Grafting and a Cemented Cup in Patients Younger Than 50 Years of Age
Authors: Schmitz Marloes W.J.L. , Hannink Gerjon , Gardeniers Jean W.M. , Verdonschot Nico , Slooff Tom J.J.H. , Schreurs B. Willem
Published: October 2017

We present an update of 19 acetabular reconstructions, performed with a cemented total hip arthroplasty and impaction bone-grafting, in situ at the time of our previous report. At a mean follow-up of 30 years (range, 27 to 35 years), no additional patients were lost to follow-up. Two patients (3 reconstructions) died for reasons unrelated to the hip surgery. Five reconstructions (5 patients) were revised, 4 for aseptic loosening and 1 for septic loosening, after a mean of 24 years (range, 22 to 27 years), leaving 11 surviving hips (11 patients) that were clinically and radiographically evaluated. Kaplan-Meier survival at 30 years was 0.40 (95% confidence interval [CI], 0.23 to 0.56) for revision for any reason, 0.56 (95% CI, 0.35 to 0.73) for aseptic loosening, and 0.53 (95% CI, 0.33 to 0.69) for radiographic loosening. Competing risk analysis showed that Kaplan-Meier analysis overestimates the revision risk by 18% for revision for any reason and 22% for aseptic loosening. Cemented impaction bone-grafting is a reasonable long-term solution for demanding primary and revision acetabular reconstructions in young patients with acetabular bone defects.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Results of Porous-Coated Anatomic Total Hip Arthroplasty without Cement at 25 to 30 Years
Authors: Slaven Sean E. , Purcell Richard L. , Mack Andrew W. , Bedard Nicholas A. , Warth Lucian C. , Callaghan John J.
Published: October 2017

The purpose of this study was to update the results of a prospective series of 100 primary cementless total hip arthroplasty (THA) procedures that were performed between 1983 and 1986 with use of the Porous Coated Anatomic (PCA) system. This is one of the first prospective studies of cementless primary THA with a minimum of 25 years of follow-up. Twenty-one patients (22 hips) of the original series were alive and had clinical and radiographic follow-up at a minimum of 25 years postoperatively. Twenty-three percent (23) of all hips and 50% (11) of the hips among the living cohort had undergone revision for loosening and/or osteolysis of the acetabular component, and 7% (7) of all hips and 4.5% (1) of the hips among the living cohort were revised for loosening and/or osteolysis of the femoral component. Only 4 femoral stems were revised for isolated loosening (without osteolysis). The PCA femoral component proved to be durable at a minimum of 25 years postoperatively, while the acetabular component was less durable.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Condyle-Specific Matching Does Not Improve Midterm Clinical Outcomes of Osteochondral Allograft Transplantation in the Knee
Authors: Wang Dean , Jones Kristofer J. , Eliasberg Claire D. , Pais Mollyann D. , Rodeo Scott A. , Williams Riley J.
Published: October 2017

Background:

Condyle-specific matching for osteochondral allograft transplantation (OCA) pairs donor and recipient condyles in an attempt to minimize articular incongruity. While the majority of cartilage defects are located on the medial femoral condyle, lateral femoral condyles are more commonly available as a graft source. The purpose of this study was to compare the clinical outcomes of patients treated with non-orthotopic (lateral-to-medial condyle or medial-to-lateral condyle) OCA with those treated with traditional orthotopic (medial-to-medial condyle or lateral-to-lateral condyle) OCA. We hypothesized that clinical outcomes would be similar between groups at midterm follow-up.

Methods:

A retrospective review of prospectively collected data on patients treated with OCA from 2000 to 2014 was conducted. Seventy-seven patients with a full-thickness cartilage defect of a femoral condyle were treated with either orthotopic (n = 50) or non-orthotopic (n = 27) OCA. A minimum follow-up of 2 years was required for analysis. Patients in each group were matched according to sex, age, and total chondral defect size. Reoperations and patient responses to validated outcome measures were reviewed. Failure was defined as any revision cartilage procedure or conversion to knee arthroplasty.

Results:

The mean duration of follow-up was 4.0 years (range, 2 to 16 years). The orthotopic and non-orthotopic OCA groups were comparable in terms of demographics, the mean number of prior ipsilateral knee operations, and the percentage of concomitant procedures at baseline. Reoperation (p = 0.427) and failure (p = 0.917) rates did not differ significantly between groups. Both groups demonstrated significant increases in the Short Form-36 (SF-36) physical functioning and pain, International Knee Documentation Committee (IKDC), and Knee Outcome Survey-Activities of Daily Living (KOS-ADL) scores compared with baseline (p < 0.004). Outcome scores (baseline and postoperative) and change scores did not differ significantly between groups.

Conclusions:

Clinical outcomes do not differ between patients treated with orthotopic OCA and those treated with non-orthotopic OCA, suggesting that condyle-specific matching may not be necessary.

Level of Evidence:

Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
The Influence of Facility and Service Quality towards Customer Satisfaction and Its Impact on Customer Loyalty in Borobudur Hotel in Jakarta
Authors: Nurcahyo Rianto , Fitriyani Annisa , Hudda Irma Nur
Published: October 2017

Hotel developments currently grow very rapidly. The emergence of new hotels increases the competition in the hospitality industry. This research aimed to determine the influence of the facilities, the quality of service to customer satisfaction and its impact on customer loyalty in Borobudur Hotel in Jakarta. Data collection were done by distributing questionnaires directly to 360 customers in Borobudur Hotel, Jakarta. The analysis technique used path analysis. The results of this research indicate that the variables of facilities, service quality, and customer satisfaction significantly affect customer loyalty variables simultaneously or partially. In addition, facilities and quality of service variable have a significant effect on customer satisfaction variables.
Banking Sector Reforms and Economic Growth: Recent Evidence from a Reform-Bound Economy
Authors: Ishioro Bernhard O
Published: October 2017

This research investigated the banking sector reforms and economic growth using time series data from 1970 to 2013 for the Nigerian economy. Autoregressive Distributed Lags (ARDL) Bounds test was applied for the specific determination of the long and short-run relationships between banking sector reforms and economic growth. The research finds that the interest rate margin is more significant than other variables in the model in explaining the banking sector reforms and economic growth. Banking sector credit to the private sector was negative and statistically insignificant in economic growth in Nigeria. This means that the size of the banking sector does not enhance economic growth. Meanwhile, inflation is negatively and statistically significant in economic growth. The duration of banking sector reforms should be defined and strictly adhered to irrespective changes in the political administration of the country.
Firm Size as Moderator to Non-Linear Leverage-Performance Relation: An Emerging Market Review
Authors: Farooq Umar , Jibran Ali Qamar
Published: October 2017

The purpose of this research was to investigate leverage-performance relation with moderating firm size in developing countries like Pakistan. Data were collected from 304 Pakistani non-financial firms for the period of 2005-2013. It is found that overall leverage-performance relation is negative for all types of firms. However,such losses are more prominent for small size firms. Results also show that the leverage-performance relation is nonlinear for medium and large size firms. However, these firms are not targeting optimal level and overleveraging that ultimately decrease their profits. So, financial managers of small size firms should avoid debt financing while for large and medium size firms, managers need to adjust their debt ratio to its optimal level.
Affective Commitment to Organizations: A Comparison Study of Reverse Mentoring Versus Traditional Mentoring Among Millennials
Authors: Hechl Catrin
Published: October 2017

A current topic of interest in management and organization research is the phenomenon of a generation shift in the workforce and how this shift will affect organizations in the near future.  Millennials represent the largest generational cohort in the American workforce.  Organizations find themselves challenged with retention efforts as Millennials tend to leave an organization after short tenures.  The problem this study addressed is the high turnover rates among millennial employees. Specifically, it was unknown whether Millennials who received reverse mentoring evidenced greater affective commitment to the organization as compared to Millennials who received standard mentoring.  The purpose of this study was to investigate the hypothesis that Millennials who received reverse mentoring evidenced greater affective commitment to the organization as compared to Millennials who received standard mentoring.  A two group post-test only quasi-experimental design was conducted.  A total of 90 participants (45 per group) completed the survey.  The survey was conducted by Qualtrics, an online survey company.  The sample population included male and female individuals, born between 1982 and 1998, employed by all types of organizations in the United States and participating in a mentoring program at the time the survey was taken.  Affective commitment was greater in the reverse mentoring group (M = 36.683, SE = .959) compared to the traditional mentoring group (M = 34.984, SE = .959).  However, after adjustment for quality of relationship (LMX) and length and frequency of mentoring (LFM) there was no statistically significant difference (p < .05) between traditional mentoring and reverse mentoring on affective commitment to the organization indicated by F(1,86) = 1.569, p = .214.  Additional results of this study showed that two-thirds of the surveyed millennial employees had already exceeded the average length of employment of 12 to 18 months with the organization they were employed with at the time of the survey.  This finding indicated the importance of investing in workplace relationships, such as mentoring, regardless of traditional or reverse.
Potential Threats of Information Disclosure in Social Media: a Systematic Literature Review
Authors: Yulianto Budi , Purnomo Fredy , Madyatmadja Evaristus Didik , Meyliana Meyliana , Prabowo Harjanto
Published: October 2017

Along with the growth of social media, a variety of potential threats to users is also increasing. These kinds of threats often occur because the users accidentally or unknowingly disclose their information or identity on social media. Threats resulted from the disclosure of information are needed to be known so that the users can understand the risks that arise and take precautions. This research was aimed to summarize the potential threats arising from the information disclosure in social media. The research method used was a systematic literature review to explore and summarize the literatures that discuss the specific topic. The research results show that the potential threats are mostly social threats and identity theft.
Shortest Path with Dynamic Weight Implementation using Dijkstra’s Algorithm
Authors: Tamatjita Elizabeth Nurmiyati , Mahastama Aditya Wikan
Published: October 2017

Shortest path algorithms have been long applied to solve daily problems by selecting the most feasible route with minimum cost or time. However, some of the problems are not simple. This study applied the case using Dijkstra's algorithm on a graph representing street routes with two possible digraphs: one-way and twoway. Each cost was able to be changed anytime, representing the change in traffic condition. Results show that the usage of one way digraph in mapping the route does make the goal possible to reach, while the usage of twoway digraph may cause confusion although it is probably the possible choice in the real world. Both experiments showed that there are no additional computation stresses in re-calculating the shortest path while going halfway to reach the goal.
An Implementation of Location Based Service (LBS) for Community Tracking
Authors: Yulianto Budi , Layona Rita
Published: October 2017

The case of lost or missing children when people go traveling or in the hustle often occurs due to lack of parental supervision. These problems can be solved using Global Position System (GPS)-based navigation technology Location Based Service (LBS). This research aimed to determine the position of members of the community (such as family) who were lost or missing by using mobile devices. Rapid Application Development (RAD) was used for system development, which comprised the step of requirement or planning, system design, development, and cutover. The result of this research is a GPS-based application that is able to display the position of members of the community, the route to the location, and the media discussion (comments). The conclusions show that the application provides an easy and useful function in finding the location of the community member, displays the route to the location, and allows the interaction in the form of communication.
Predicting and Analyzing the Length of Study-Time Case Study: Computer Science Students
Authors: Handhayani Teny , Hiryanto Lely
Published: October 2017

The length of study-time is one of the important issues in higher education. The goal of this research was to predict and analyze the length of studytime in the early stage of Computer Science students in X University. The research proposed Mutual Information (MI) as feature selection method and Support Vector Machine (SVM) as a classification method. There were two different sections of the experiments. The first experiment used two class targets that were grouped in ‘on time group’ and ‘late group’. The experiment result shows that the proposed method produces accuracy around 85%. The second experiment used three class targets, ‘on time group’, ‘late group’, and ‘very late group’. The experiment result of the proposed method produces accuracy around 80%. Mutual Information (MI) does not only successfully raise the accuracy but also uncovers the relationship between subjects and the class targets.
The Development of Indoor Object Recognition Tool for People with Low Vision and Blindness
Authors: Sutoyo Rhio , Chowanda Andry
Published: October 2017

The purpose of this research was to develop methods and algorithms that could be applied as the underlying base for developing an object recognition tools. The method implemented in this research was initial problem identification, methods and algorithms testing and development, image database modeling, system development, and training and testing. As a result, the system can perform with 93,46% of accuracy for indoor object recognition. Even though the system achieves relatively high accuracy in recognizing objects, it is still limited to a single object detection and not able to recognize the object in real time.
Penerapan Kaidah al-Ghunm bi al-Ghurm dalam Pembiayaan Mushārakah pada Perbankan Syariah
Authors: Adinugraha Hendri Hermawan
Published: October 2017

This purpose of this research is to describe the theoretical study of the principle of al-ghunm bi al-ghurm in detail and its implementation in mushārakah  financing at Islamic banking. The type of research has been included in the library research category which is writing the data and information obtained from published sources. Therefore, this research was used literature research from journals, books and other sources related to the topic. This research used normative juridical approach, then in every analysis always refers main reference on primary sources, such as Umar Abdullah al-Kamil dissertation which entitled al-Qawa’id al-Fiqhiyyah al-Kubrā wa Atsaruhā fi al-Mu‘āmalat al-Māliyahand paper by Walid Rashid Ibn As-Sa'idan about Qawā‘id al-Buyu’ wa Farāid al-Furu’to identify the concept of al-ghunm bi al-ghurm in mushārakah  financing at Islamic banking.Tujuan penelitian ini adalah untuk mendeskripsikan dan menginterpretasikan hasil temuan/pengamatan mengenai konsep al-ghunm bi al-ghurm dalam pembiayaan mushārakah  pada perbankan syariah. Jenis penelitian ini termasuk penelitian kepustakaan (library research) dimana pengumpulan data dan informasinya diperoleh dari sumber-sumber pustaka (bacaan) yang berasal dari buku, hasil penelitian, jurnal dan bahan-bahan bacaan lainnya yang masih ada relevansinya dengan topik ini. Penelitian ini menggunakan pendekatan yuridis normatif, maka dalam setiap analisa selalu merujuk (rujukan utama) pada sumber primer yaitu disertasi Umar Abdullah al-Kamil yang berjudul al-Qawa’id al-Fiqhiyyah al-Kubrā wa Atharuhā fi al-Mu‘āmalat al-Māliyah dan paper karya Walid Ibnu Rasyid As-Sa’idan tentang Qawā‘id al-Buyu’ wa Farāiḍ al-Furu’ untuk mengidentifikasi konsep al-ghunm bi al-ghurm dalam pembiayaan mushārakah  pada perbankan syariah.
Dampak Indikator Makro Ekonomi terhadap Dana Pihak Ketiga Perbankan Syariah
Authors: Saekhu Saekhu
Published: October 2017

This study was undertaken to analyze the effects of macroeconomic indicators (SBI interest rate, exchange rate, inflation, Indonesia Composite Index and GDP) to deposits liabilities of Islamic Banking in Indonesia. Analysis unit of this study is the Islamic Banking in Indonesia during the period 1998-2008. For the empirical analysis in this study it is used the data on aggregate time series of the monthly period from January 2003 to December 2010. Source data taken from publication of Bank Indonesia, in the form of Annual Report Bank Indonesia,  Indonesia Bank Monetary Statement Of Policy, Statistics Economic and Financial Indonesia, Islamic Banking Statistics (Statistik Perbankan Syariah/SPS) and publication report from Badan Pusat Statistik (BPS). This study uses Linear Regression analysis with Ordinary Least Square (OLS) method. The result show that macroeconomic indicators have impact on Funding (deposit liabilities) of Bank Syariah Mandiri, the SBI interest rate have negative impact, while exchange rate, inflation, Indonesia Composite Index and GDP have positive impact. Based on the same method, it shows that GDP has positive on Funding of Islamic Banking in Indonesia.Penelitian ini dilakukan untuk menganalisis dampak indikator makro ekonomi (suku bunga SBI, nilai tukar, inflasi, Indeks Harga Saham Gabungan Indonesia dan PDB) terhadap deposito (Dana Pihak Ketiga) Perbankan Syariah di Indonesia. Unit analisis penelitian ini adalah Perbankan Syariah di Indonesia selama periode 1998-2008. Analisis empiris dalam penelitian ini menggunakan data kumpulan waktu agregat periode bulanan dari Januari 2003 sampai Desember 2010. Sumber data diambil dari publikasi Bank Indonesia, berupa Laporan Tahunan Bank Indonesia, Laporan Kebijakan Moneter, Statistik Ekonomi dan Keuangan Indonesia/SEKI), Statistik Perbankan Syariah (SPS) dan laporan publikasi Badan Pusat Statistik (BPS). Penelitian ini menggunakan analisis Regresi Linier dengan metode Ordinary Least Square (OLS). Hasil menunjukkan bahwa indikator makro ekonomi berdampak pada pendanaan (deposito) Bank Syariah Mandiri, suku bunga SBI memiliki dampak negatif, sedangkan nilai tukar, inflasi, Indeks Harga Saham Gabungan Indonesia dan PDB berdampak positif. Berdasarkan metode yang sama, PDB positif terhadap Pendanaan Perbankan Syariah di Indonesia.
Recent Advances in the Development of Pharmaceutical Agents for Metabolic Disorders: A Computational Perspective
Authors: Janardhan Sridhara , Dubovskaja Varvara , Lagunin Alexey , Rao Batchu Venkateswara , Sastry Garikapati Narahari , Poroikov Vladimir
Published: October 2017

Background:

Metabolic disorders comprise a set of different disorders varying from
epidemic diseases such as diabetes mellitus to inborn metabolic orphan diseases such as phenylketonuria.
Despite considerable evidence showing the importance of the computational methods
in discovery and development of new pharmaceuticals, there are no systematic reviews outlining
how they are utilized in the field of metabolic disorders. This review aims to discuss the
necessity of the development of web-based tools and databases by integration of available information
for solving Big Data problems in network pharmacology of metabolic disorders.

Methods:

We undertook a structured search of bibliographic databases for peer-reviewed research
literature using a focused review question and inclusion/exclusion criteria. The quality of
retrieved papers was appraised using standard tools.

Results:

The alterations in metabolic pathways cause various cardiovascular, hematological, neurological,
gastrointestinal, immune disorders and cancer. In this regard, informatics, Big Data and
modeling techniques aid in the design of novel therapeutic agents for metabolic diseases by addressing
various Big Data problems in the network polypharmacology (drugs/pharmaceutical
agents, proteins, genes, diseases, bioassays, ADMET and metabolic pathways), identification of
privileged scaffolds, developing new diagnostic biomarkers, understanding the pathophysiology
of disease and progress in personalized medicine.

Conclusion:

The recent advances of developing pharmaceutical agents for various metabolic disorders
by considering their pathogenesis, mechanisms of action, therapeutic and adverse effects
have been summarized. We have highlighted the role of computational techniques, drug repurposing,
and network-based polypharmacological approaches in the identification of new/existing
medicines with improved drug-likeness properties for the rare metabolic disorders.
Recent Research Trends on Bismuth Compounds in Cancer Chemoand Radiotherapy
Authors: Kowalik Mateusz , Masternak Joanna , Barszcz Barbara
Published: October 2017

Background:

Application of coordination chemistry in nanotechnology is a rapidly developing research field in medicine. Bismuth complexes have been widely used in biomedicine with satisfactory therapeutic effects, mostly in Helicobacter pylori eradication, but also as potential antimicrobial and anti-leishmanial agents. Additionally, in recent years, application of bismuth-based compounds as potent anticancer drugs has been studied extensively.

Methods:

Search for data connected with recent trends on bismuth compounds in cancer chemo- and radiotherapy was carried out using web-based literature searching tools such as ScienceDirect, Springer, Royal Society of Chemistry, American Chemical Society and Wiley. Pertinent literature is covered up to 2016.

Results:

In this review, based on 213 papers, we highlighted a number of current problems connected with: (i) characterization of bismuth complexes with selected thiosemicarbazone, hydrazone, and dithiocarbamate classes of ligands as potential chemotherapeutics. Literature results derived from 50 papers show that almost all bismuth compounds inhibit growth and proliferation of breast, colon, ovarian, lung, and other tumours; (ii) pioneering research on application of bismuth-based nanoparticles and nanodots for radiosensitization. Results show great promise for improvement in therapeutic efficacy of ionizing radiation in advanced radiotherapy (described in 36 papers); and (iii) research challenges in using bismuth radionuclides in targeted radioimmunotherapy, connected with choice of adequate radionuclide, targeting vector, proper bifunctional ligand and problems with 213Bi recoil daughters toxicity (derived from 92 papers).

Conclusion:

This review presents recent research trends on bismuth compounds in cancer chemo- and radiotherapy, suggesting directions for future research.
Marine Natural Product Bis-indole Alkaloid Caulerpin: Chemistry and Biology
Authors: Lunagariya Jignesh , Bhadja Poonam , Zhong Shenghui , Vekariya Rohit , Xu Shihai
Published: October 2017

Marine bis-indole alkaloids comprise a large and increasingly growing class of secondary metabolites, and continue to deliver a great variety of structural templates for diverse biological targets. The alkaloids derived from marine resources play a crucial role in medicinal chemistry and as chemical agents. In particular, bis-indole alkaloid caulerpin which has been isolated from marine green algae Caulerpa and a red algae Chondria armata at various places around the world, was tested for several therapeutic potentials such as anti-diabetic, antinociceptive, anti-inflammatory, anti-tumor, anti- larvicidal, anti-herpes, anti-tubercular, anti-microbial and immunostimulating activities as well as a means of other chemical agents. Herein, we summarized the discovery and isolation of caulerpin, and its potential medicinal and chemical applications in chronological order with various aspects. Additionally, synthesis of caulerpin and its functional analogues have also been reviewed.
Therapeutic Potential of Alpinia officinarum
Authors: Pillai Manoharan K. , Young David J. , Bin Hj Abdul Majid Hj Mohamed
Published: October 2017

The plant Alpinia officinarum of the ginger family originated in China and is used throughout
South and South-East Asian countries to flavor food and as a traditional medicine to treat a variety
of diseases. This review summarizes the biological, pharmacological and phytochemical properties of
extracts and subsequently isolated compounds from A. officinarum. In vitro and in vivo studies of both
extracts and pure compounds indicate a wide variety of potent bioactivities including antiinflammatory,
antibacterial, antioxidant, antiobesity, anticancer, enzyme inhibitory and remarkable antiviral
properties. The latter is particularly promising in the face of emerging, virulent respiratory diseases
in Asia and the Middle East.
Ponatinib: A Review of Efficacy and Safety
Authors: Massaro Fulvio , Molica Matteo , Breccia Massimo
Published: October 2017

Ponatinib is a third generation kinase inhibitor designed to overcome the gatekeeper T315I
mutation. In different trials this drug showed inhibitory activity against native BCR-ABL1 kinase and
several ABL1 mutations. For this reason, ponatinib is currently indicated for the treatment of chronic
myeloid leukaemia (CML) in every phase of disease resistant and/or intolerant to dasatinib and
nilotinib and for whom imatinib is not indicated anymore or for patients with T315I mutation. The drug
is also indicated for Ph+ acute lymphoblastic leukaemia (ALL). Ponatinib was temporarily suspended
in 2013 for the occurrence of cardiovascular thrombotic events. Since then, different investigators analyzed
baseline characteristics of patient candidates for ponatinib, especially cardiovascular profile, in
order to describe general management recommendations in this setting.

In this review, clinical trials data about the use of ponatinib in CML and Ph+ ALL patients will be
discussed. It will be focused also about the safety and tolerability profile of the drug and future perspectives
of employment.
Oxidative Stress and Cancer: The Role of Nrf2
Authors: Sajadimajd Soraya , Khazaei Mozafar
Published: October 2017

Oxidative stress due to imbalance between ROS production and detoxification plays a
pivotal role in determining cell fate. In response to the excessive ROS, apoptotic signaling pathway
is activated to promote normal cell death. However, through deregulation of biomolecules, high
amount of ROS promotes carcinogenesis in cells with defective signaling factors. In this line, NRF2
appears to be as a master regulator, which protects cells from oxidative and electrophilic stress. Nrf2
is an intracellular transcription factor that regulates the expression of a number of genes to encode
anti-oxidative enzymes, detoxifying factors, anti-apoptotic proteins and drug transporters. Under
normal condition, Nrf2 is commonly degraded in cytoplasm by interaction with Keap1 inhibitor as
an adaptor for ubiquitination factors. However, high amount of ROS activates tyrosine kinases to
dissociate Nrf2: Keap1 complex, nuclear import of Nrf2 and coordinated activation of cytoprotective
gene expression. Nevertheless, deregulation of Nrf2 and/or Keap1 due to mutation and activated upstream
oncogenes is associated with nuclear accumulation and constitutive activation of Nrf2 to protect
cells from apoptosis and induce proliferation, metastasis and chemoresistance. Owning to the
interplay of ROS and Nrf2 signaling pathways with carcinogenesis, Nrf2 modulation seems to be
important in the personalization of cancer therapy.
Leaf and seedling morphology: the two prospective parameters to trace phylogeny in apiaceae subfamily apioideae.
Authors: Das Saubhik
Published: October 2017

Determination of phylogenetic affinity among the members of Apiaceae especially the subfamily Apioideae is much debatable. The morphological evidences on inflorescence, fruit and seed characters showed little concomitance with those derived from molecular parameters as far as groupings in clades are concerned. In the present study involving few selected Apiaceae members, a Dendrogram was computed and a putative evolutionary trend was outlined based on leaf margin insertion pattern and cotyledonary leaf features, general plant morphology as well as leaf surface micromorphology by SEM. The members of Apiaceae with broad-ovate pinnatifid to pinnatipartite leaves and ovate –lanceolate cotyledonary leaves were included in a distinct cluster but the members with pinnatisect – decompounds leaves and linear cotyledonary leaves were included in a separate cluster. Long Coriander (Eryngium foetidum) included in the subfamily Saniculoideae may represent the most primitive condition having simple entire leaf with spiny margin. The member like Long coriander might have served as progenitor stock from which Coriander, Celery, Parsley (all with ovate pinnatifid to pinnatipartite leaves) and Cumin, Fennel, Dill (all having pinnatisect to decompounds leaves with linear segments) might have originated as evidenced by gradual increase in marginal insertion. Similarly, gradual narrowing of ovate-lanceolate cotyledonary leaves might have given rise to narrow linear cotyledonary leaves. Leaf-margin insertion pattern and cotyledonary leaf features appeared to be promising in tracing phylogeny in Apiaceae especially in Apioideae. Simple entire leaf represents the primitive condition and evolution in Apiaceae supposed to have progressed towards gradual increase in marginal insertion leading to pinnately dissected, pinnatipartite and ultimately to decompound leaves with narrow linear segments. Dendrogram computed from morphological features showed concomitance with that phylogenetic trend as far as grouping and interrelationships of members are concerned.  In the present study leaf margin insertion pattern and seedling morphology appeared to be instrumental in tracing the phylogeny in Apiaceae specially subfamily Apioideae while molecular systematics are not conclusive.
Fimbristylis scabrida (Cyperaceae): a new record for Asian Continent
Authors: A.R. Viji , T.S. Preetha
Published: October 2017

Fimbristylis scabrida Schumach. (Cyperaceae), an African sedge species is reported here for the first time from the Western Ghats of India in the Asian continent. A brief description, notes and colour photographs are provided for easy identification.
INFLUENCE OF CLASSROOM MANAGEMENT ON THE PERSONALITY OF IX STANDARD STUDENTS IN MADURAI
Authors: Maruthavanan M.
Published: October 2017

This study investigated the influence of personality on the class room management of IXth standard students in Madurai district. Psychoanalysts believe man’s behaviour is triggered mostly by powerful hidden forces within the personality. Sigmund Freud, an Australian physician was the originator of this theory in the early nineties He says much of people’s everyday behaviour is motivated by unconscious forces about which they know little. In order to fully understand personality then one need to illuminate and expose what is in the unconscious. Class room management is very important task in the teaching learning process. Without class room management skill teaching skill has made no effect in the class room. In the study the researcher take IX standard students in Madurai district. In this study researcher proved the above statement. He Proved that the classroom management is directly related with the personality.
ATTITUDE OF TRIBAL AND NON TRIBAL STUDENTS TOWARDS MODERNIZATION
Authors: . Shobha , Dhawan Seema
Published: October 2017

Globalization in literal sense is a process of transformation of regional or local phenomena into a global one. Impact of globalization is universal which can be observed in all the aspects of life viz. economic, social, cultural, political, finance, health, nutrition and technological dimensions of the world. In present era of scientific innovations, the process of globalization has brought the people in contact of outside society. Globalization process is also called modernization which include development of science and technology and, communication by which all the places are interconnected and people become more migratory. History demonstrates that significant changes in a people's social and economic climate usually bring about new developments in ideology and in religious practices. Tribal, mostly live in forest, hills and other naturally isolated regions and their lifestyles are conditioned by ecological setting they live. It is being widely seen today that the traditional features of tribal life is gradually changing from being deeply ingrained in tribal beliefs, customs and traditions to something that is more modernized, in a developmental sense, due to adaptation of modern ways of living and altered life-style pattern. In general, only those tribes those remain geographically isolated in desert, hill, and forest regions or on islands are able to retain their traditional cultures and religions for longer periods.An attempt has been taken to study the attitude of college going tribal and non tribal students towards modernization. The study included college going tribal and non tribal of district Dehradun.
हिन्दी शिक्षण में कुशल अनुदेशनात्मक नीतियों का महत्व
Authors: यादव आशा , . प्रवीण
Published: October 2017

वर्तमान समय में शिक्षा के सभी स्तरों पर शैक्षिक तकनीकी का उपयोग प्रमुखता से किया जा रहा है। वस्तुत हिन्दी शिक्षण को प्रभावकारी या रोचक बनाने के लिए शैक्षिक तकनीकी के कुशल अनुदेशनात्मक नीतियों का वर्णन और उनका हिन्दी शिक्षण में महत्व इस शोध लेख का मुख्य उद्वेश्य है। पाठ्यक्रम के अन्य विषयों की भांति हिन्दी में भी कुशल अनुदेशनात्मक नीतियां उपयोगी हो सकते है। प्रोफेसर वैबर के सिद्वध किया है कि ज्ञान ग्रहण की प्रक्रिया में 40 प्रतिशत ज्ञान हम आँखों के माध्यम से, 25 प्रतिशत श्रवणों के माध्यम से, 17 प्रतिशत हम स्पर्श के द्वारा प्राप्त करते है। इस प्रकार नई तकनीकी द्वारा दृश्य एवम् श्रव्य उपकरणों के द्वारा हमें अधिकाधिक ज्ञान प्राप्त होता है। यह ज्ञान अप्रेक्षाकृत अधिक स्थायी होता है। इसलिए कुशल अनुदेशनात्मक साधनों को हिन्दी भाषा के शिक्षण में प्रयुक्त करके हम उसे सरल, सहजग्राह्य, स्पष्ट, रूचिकर, बोधग्रम्य, प्रभावाशाली एवम् प्रेरक बना सकते है।
Use of Electronic Entertainment and Communication Devices Among a Saudi Pediatric Population: Cross-Sectional Study (Preprint)
Authors: Amawi Sami Omar , Subki Ahmed Hussein , Khatib Hazim Abdulkarim , Alkhateeb Omer Sameer , Fida Rida Hashim , Saggaf Omar Mohammed , Jan Mohammed Mohammed
Published: October 2017

BACKGROUND

Excessive use of various electronic entertainment and communication devices, particularly among children, has been associated with increased behavioral problems. Despite children’s escalating use of these devices, parents’ awareness about the impact thereof is still lacking.

OBJECTIVE

The objective of this study was to assess the use of electronic entertainment and communication devices among children attending a health care facility in Jeddah, Saudi Arabia, as well as the parental impression regarding the impact of electronic devices use on the behavior of their child.

METHODS

A focused 15-item questionnaire was designed for this cross-sectional study involving mothers of children attending the Well Baby Clinic of King Abdulaziz University Hospital, Jeddah, Saudi Arabia from July 1, 2016 to November 30, 2016.

RESULTS

This study included 190 mothers. The mean ages of the children, mothers, and fathers were 7.3 (SD 3.5), 35 (SD 6.5), and 43 (SD 8.3) years, respectively. Most children were of Saudi Arabian nationality (106/190, 55.8%). The most used device in this study was television (154/190, 81.0%), followed by mobile phones (134/190, 70.5%), and tablets (116/190, 61.0%). Computers were the least used device in this study (59/190, 31.0%). In total, 24.7% (47/190) of children in this study used electronic entertainment and communication devices for more than 4 hours per day. Most mothers (129/190, 67.9%) felt that their child spends too much time on electronic devices. Hyperactivity or behavioral problems were reported by 20.0% (38/190) of mothers in this study. Children spending longer hours on electronic devices were much more likely to be perceived to suffer from hyperactivity or behavioral problems (P=.01).

CONCLUSIONS

Parental awareness is necessary to counteract the harmful effects of using electronic devices for a prolonged period. Parents require help to cope with this problem effectively.
Understanding the endocannabinoid system as a modulator of the trigeminal pain response to concussion
Authors: Elliott Melanie B , Ward Sara J , Abood Mary E , Tuma Ronald F , Jallo Jack I
Published: October 2017

Post-traumatic headache is the most common symptom of postconcussion syndrome and becomes a chronic neurological disorder in a substantial proportion of patients. This review provides a brief overview of the epidemiology of postconcussion headache, research models used to study this disorder, as well as the proposed mechanisms. An objective of this review is to enhance the understanding of how the endogenous cannabinoid system is essential for maintaining the balance of the CNS and regulating inflammation after injury, and in turn making the endocannabinoid system a potential modulator of the trigeminal response to concussion. The review describes the role of endocannabinoid modulation of pain and the potential for use of phytocannabinoids to treat pain, migraine and concussion.
DESENTRALISASI FISKAL KONTEMPORER DALAM PERSPEKTIF KEBIJAKAN PUBLIK ISLAM
Authors: Setianingrum Any
Published: October 2017

One of the essential instruments designed for achieving the goals of sharia in Islam is fiscal policy. There are some key elements of Islamic fiscal theory, namely: 1) Islamic Economics, which comprises private sector, social/ voluntary sector, and public sector. The collaboration of these three sectors would provide an ideal Islamic economic institutional framework; 2) Zakat (taxation of income and wealth of a Muslim) as the basis of fiscal system; 3) Implementation of all fiscal instruments which disallow exploitation that results in usury (riba), uncertainty (gharar ), speculation, sinful (haram) products / services and all forms of meanness. 4) Allocation, distribution and stabilization functions of Islamic economics is administered and presented through all the sectors cooperatively; 5) Public sector does not affect significantly yet essential on condition that it works continuously to ensure optimum allocation of society resources, income distribution, and stability establishing
PENGARUH INVESTASI DAN BELANJA PEMERINTAH TERHADAP PERTUMBUHAN EKONOMI DAN PAD DI KABUPATEN BERAU
Authors: U Abdurrahman
Published: October 2017

The first purpose of the research was to determine the direct and indirect influence of Investment and Government Expenditure on Economic Growth and Regional Income in Berau, while the second purpose was to identify the direct influence of Economic Growth on Regional Income in Berau. In order to get accurate results, the research implemented 2 regression lines to analyze the data. The finding shown in Line Diagram 1 indicated that investment and government expenditure had a direct and significant effect on economic growth in Berau. Meanwhile, on the Line Diagram 2, it appears that investment and government expenditure had a direct effect and an indirect but significant impact on Regional Income in Berau.
KARAKTERISTIK MANTAN BURUH MIGRAN INDONESIA PENERIMA DANA CSR PERBANKAN DI KECAMATAN DONOMULYO KABUPATEN MALANG
Authors: Latifah Sri Wahjuni
Published: October 2017

Research on the characteristics of Indonesian Migrant Workers Former grantees Banking CSR is done in District Donomulyo Malang. The purpose of this study is to provide empirical evidence about the characteristics of former migrant workers so as to be considered the government to improve their welfare. Quota sampling techniques obtained 45 respondents. Data analysis with quantitative and qualitative approaches. The results of this study indicate that migrant workers productive age (35.28 years) with an average experience of 5.8 years. The level of high school education. His favorite of Taiwan. Investment enough value the average Rp.108.000.000