bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementasi Metode Vikor untuk Pemilihan Lansia yang Menerima Bantuan Sosial
Authors: Novriani Nisa , Irianto Irianto , Rohminatin Rohminatin
Published: March 2022

Abstrak: Isu demografi tentang usia harapan hidup bagi lanjut usia di Indonesia sangat berpengaruh terhadap permasalahan yang timbul, hal ini tidak hanya secara kuantitas jumlah lanjut usia bertambah, tetapi juga karena kerentanannya lansia (lanjut usia) perlu diperhatikan dan dilindungi. Berdasarkan kenyataan tersebut, pemerintah mengambil peran yang sangat diperlukan dalam upaya mengurangi kemiskinan para lanjut usia terlantar dalam bentuk bantuan sosial. Pemberian bantuan sosial yang dilakukan oleh Dinas Sosial Kota Tanjungbalai. Instansi tersebut memberikan bantuan sosial kepada lansia berupa uang tunai. Permasalahan yang muncul adalah ketika kuota pemberian bantuan sosial yang diberikan lebih sedikit dibandingkan dengan calon penerima bantuan. Sehingga sulitnya Dinas Sosial Kota Tanjungbalai menyeleksi proposal untuk menentukan lansia yang akan diberikan bantuan sosial. Mengatasi tersebut maka dibutuhkan suatu sistem pendukung keputusan yang membantu pihak Dinas Sosial Kota Tanjungbalai dalam memberikan keputusan. Adapun metode sistem pendukung keputusan yang digunakan adalah metode VIKOR (Vise Kriterijumska Optimizacija I Kompromisno Resenje). Kata kunci: Metode Vikor; Pemilihan Lansia; Penerima Bantuan Sosial  Abstract:Demographic issues regarding life expectancy for the elderly in Indonesia are very influential on the problems that arise, this is not only quantitatively the number of elderly people increases, but also because the vulnerability of the elderly (elderly) needs to be considered and protected. Based on this fact, the government takes an indispensable role in efforts to reduce the poverty of neglected elderly people in the form of social assistance. Social assistance provided by the Tanjungbalai City Social Service. The agency provides social assistance to the elderly in the form of cash. The problem that arises is when the quota for social assistance provided is less than the potential beneficiaries. So that it is difficult for the Tanjungbalai City Social Service to select proposals to determine the elderly who will be given social assistance. To overcome this, a decision support system is needed that helps the Tanjungbalai City Social Service in making decisions. The decision support system method used is the VIKOR method ((Vise Kriterijumska Optimizacija I Kompromisno Resenje)Keywords: Vikor Method; Selection of Elderly; Recipients of Social Assistance
Alat Pengenalan Huruf Braille untuk Murid Tunanetra dengan Kontrol Android
Authors: Maruzi Muchlis , Nofriadi Nofriadi , Syahputra Abdul Karim
Published: March 2022

Abstract: Education is one of the basic needs that must be met by every individual. Everyone has the right to receive proper education, both normal people and people with special needs, one of which is people with visual needs. In the learning process, blind people generally use special letters in terms of reading and writing, namely braille letters or characters. From the results of observations at SDLB Negeri 017700, a problem was found, namely that there were no special teachers who taught braille and students still had difficulty recognizing braille letters. Therefore, a tool is proposed, namely a braille letter recognition tool with android control based on Arduino with a Servo motor as the tool driver and HC-05 as a link between Android and the device being made. This tool not only aims to assist teachers in delivering material about braille letters, but also aims to help students recognize braille letters. Keywords: Android; Arduino; Braille letters; Education; tool  Abstrak: Pendidikan merupakan salah satu kebutuhan pokok yang harus dipenuhi setiap individu. Semua orang berhak menerima pendidikan yang layak, baik orang normal maupun orang dengan kebutuhan khusus salah satunya orang dengan kebutuhan Tunanetra. Dalam proses pembelajarannya, penyandang tunanetra umumnya menggunakan huruf khusus dalam hal membaca dan menulis yaitu huruf atau aksara braille. Dari hasil observasi di SDLB Negeri 017700, ditemukan masalah yaitu belum adanya guru khusus yang mengajarkan huruf braille dan murid masih kesulitan dalam mengenali huruf braille. Oleh karena itu, diusulkan alat yaitu alat pengenalan huruf braille dengan kontrol android dengan berbasiskan Arduino dengan motor Servo sebagai penggerak alat dan HC-05 sebagai penghubung antara android dan alat yang dibuat. Alat ini selain bertujuan untuk membantu guru dalam menyampaikan materi tentang huruf braille, tetapi bertujuan juga untuk membantu murid dalam mengenali huruf braille. Kata Kunci: Alat; Android; Arduino; Huruf Braille; Pendidikan
Penerapan Metode C4.5 Untuk Penentuan Kelayakan Penerima Program Keluarga Harapan
Authors: Saragih Irfan Abadi , Firmansyah Ada Udi , Rohminatin Rohminatin
Published: March 2022

Abstract: The Hope Family Program is a program that provides cash assistance to Very Poor Households (RTSM). In return, RTSM is required to meet requirements related to efforts to improve the quality of human resources, namely education and health. Hopefully the Family of Hope Program is expected to reduce the burden of spending on poor families in the short term and break the chain of poverty in the long term. Data mining is an analysis step of the knowledge discovery process in the database using the C4.5 Algorithm. The C4.5 algorithm will form a decision tree which can later be used as a basis for consideration in determining the eligibility of the Family Hope Program recipients. The purpose of this research is to help determine the eligibility of the Family Hope Program recipients. The limitations of this study are using data that will be implemented in making applications with Visual Basic .NET 2010. The research method  uses quantitative methods, where the research is descriptive, refers to data and utilizes existing the ories as supporting materials. From the results of this study, a system that can help facilitate  the determination of eligibility for the Family Hope Program recipient will be made. Keywords: Data Mining; Algorithm C4.5; appropriateness PKH; PKH; Dinas Sosial  Abstrak: Program Keluarga Harapan merupakan program yang memberikan bantuan tunai kepada  Rumah Tangga Sangat Miskin (RTSM). Sebagai imbalannya RTSM diwajibkan memenuhi persyaratan terkait dengan upaya peningkatan kualitas sumber daya manusia, yaitu pendidikan dan kesehatan. Program Keluarga Harapan diharapkan dapat mengurangi beban pengeluaran keluarga miskin dalam jangka pendek serta memutus rantai kemiskinan dalam jangka panjang. Data mining merupakan langkah analisis terhadap proses penemuan pengetahuan didalam basis data dengan menggunakan Algoritma C4.5. Algoritma C4.5 akan membentuk pohon keputusan yang nantinya dapat digunakan sebagai dasar pertimbangan dalam penentuan kelayakan penerima Program Keluarga Harapan. Tujuan penelitian ini dilakukan untuk membantu penentuan kelayakan penerima Program Keluarga Harapan. Adapun batasan pada penelitian ini yaitu menggunakan data    yang akan diimplementasikan dalam pembuatan aplikasi dengan Visual Basic .NET 2010. Metode        penelitian menggunakan metode kuantitatif, dimana penelitian bersifat deskripsi, mengacu pada data dan memanfaatkan teori yang ada sebagai bahan pendukung. Dari hasil penelitian ini maka  akan dibuat sebuah sistem yang mampu membantu mempermudah dalam penentuan kelayakan penerima Program Keluarga Harapan. Kata kunci: Data Mining; Algoritma C4.5; Kelayakan PKH; PKH; Dinas Sosial
Sistem Pendukung Keputusan Penentuan Rumah Tangga Miskin Menggunakan Metode Simple Additive Weighting (SAW)
Authors: Safitri Febi , Tasril Virdyra , Kurniawan Heri
Published: March 2022

Abstract: The formation of poverty is due to low levels of education, high levels of unemployment, differences of opinion and others. This problem is also found in Indonesia. There are many ways to deal with poverty alleviation by the government and the private sector in providing assistance to poor families. But in reality, there are many aids that have been given for poverty management efforts which are not right on target. The author makes a decision support system application to determine poor families that can help the parties involved in recording and determining it quickly and efficiently, so that the data collected will be accurate. This decision support system application uses the Simple Additive Weighting (SAW) method which is used to solve a simple unstructured problem. So that by applying this method, it will help the decision-making process in determining poor households in Medan City. Keywords: BPS (Central Statistics Agency);Poor Households;SAW;User;Web  Abstrak: Terbentuknya kemiskinan dikarenakan adanya tingkat pendidikan yang rendah, tingkat pengangguran yang tinggi, perbedaan pendapat dan lain-lain. Persoalan ini juga ditemukan dinegara indonesia. Untuk melakukan penanganan kemiskinan tersebut banyak cara yang dilakukan oleh pemerintah maupun pihak swasta dalam memberikan bantuan-bantuan terhadap keluarga miskin. Tetapi pada kenyataan yang dihadapi banyak bantuan-bantuan yang telah diberikan untuk upaya penanganan kemisikinan yang banyak tidak tepat pada sasaran. Penulis membuat sebuah aplikasi sistem pendukung keputusan untuk menentukan keluarga miskin yang dapat membantu pihak yang terkait dalam mendata dan menentukannya secara cepat dan efisien, sehingga hasil pendataan yang didapatkan akan akurat. Aplikasi sistem pendukung keputusan ini menggunakan metode Simple Additive Weighting (SAW) yang digunakan untuk menyelesaikan suatu persoalan yang tidak terstruktur secara sederhana. Sehingga dengan menerapkan metode tersebut, akan membantu proses pengambilan keputusan dalam penentuan rumah tangga miskin di Kota Medan. Kata Kunci: BPS (Badan Pusat Statistik);Rumah Tangga Miskin;SAW;User;Web
Perancangan Sistem Switch Lampu Pintar Dengan Kendali Android Dan Light Dependent Resistor Di SMK Negeri 5 Tanjungbalai
Authors: Hidayat Surya , Amin Muhammad , Sudarmin Sudarmin
Published: March 2022

Abstract: Vocational High School 5 Tanjungbalai is one of the public schools in the city of Tanjungbalai, this school has two majors, namely motorcycle engineering (TSM) and electric power installation (TITL). During this time the electricity supply from this school was taken from PLN, and the light switch system from this school still uses a manual switch, so that each class installs a planting switch, so if the teacher or student wants to install lights, then the light switch must be activated. Still using this manual light switch, teachers and students often forget to turn on the lights, and usually these lights are left on. Each classroom and teacher's room is fitted with 1 lamp and 1 manual switch, so that each class or room has a different flow of cables. Founded from the problems that exist in SMKN 5 Tanjungbalai, as well as a literature study of the research conducted, the researcher wants to discuss about a device that is able to move using Android, besides that it also creates an intelligent device, and the lights will turn off. How to activate the LDR sensor or sensor light. Keywords: Light Switch System; Android Control; Lamp Resistance SMK Negeri 5 Tanjungbalai  Abstrak: SMK Negeri 5 Tanjungbalai merupakan salah satu sekolah negeri yang berada dikota tanjungbalai, sekolah ini memiliki dua jurusan yaitu Teknik Sepeda Motor (TSM) dan Teknik Instalasi Tenaga Listrik (TITL). Selama ini suply listrik dari sekolah ini diambil dari PLN, dan sistem switch lampu dari sekolah ini masih menggunakan switch manual, dimana tiap kelas memasang switch lampu tanam, sehingga jika guru atau siswa ingin menyalakan lampu, maka switch lampu tersebut harus diaktifkan. Masih digunakannya switch lampu manual ini, sering mengakibatkan guru dan siswa lupa untuk mematikan lampu, dan biasanya lampu tersebut dibiarkan hidup seterusnya. Setiap ruangan kelas dan ruangan guru, dipasangkan 1 lampu dan 1 switch manual, sehingga setiap kelas atau ruangan memiliki aliran kabel yang berbeda beda. Didasari dari masalah yang ada di SMK Negeri 5 Tanjungbalai, serta studi literatur tentang penelitian terdahulu, maka peneliti ingin merancang sebuah alat yang mampu dikendalikan dengan menggunakan perintah android, selain itu rancangan alat tersebut juga memiliki sistem pintar, dimana lampu akan mati secara otomatis jika cuaca sudah memasuki malam hari hal ini dikarenakan penggunaan dari sensor LDR atau sensor cahaya. Kata kunci: Sistem Switch Lampu; Kendali Android; Light Dependent Resistor; SMK Negeri 5 Tanjungbalai.
Twenty Fregean Ways to Quantify Over Frege's Senses
Authors: Dejnožka Jan
Published: March 2022

This paper continues my discussion with Michael Dummett on Frege’s senses, published in The Philosophy of Michael Dummett and further developed in Diametros. In his reply to my original paper, Dummett came to agree with me that senses are neither objects nor functions, since they have a categorially different kind of linguistico-metaphysical function to perform. He then asks how we might quantify over senses, if they are neither objects nor functions. He discusses two main options, and finds one unviable and the other “very un-Fregean.” I then offer a Fregean or neo-Fregean option in my rejoinder. And I still hold that this way out will do the job, or is at least plausible enough that the burden of persuasion is on those who disagree. But I hope to show in this paper that on a more complete examination of Frege, there are at least twenty Fregean or neo-Fregean ways out, with the one I proposed being option (17).
Expression of Luteinizing Hormone Receptor in the Gastrointestinal Tract in Patients with and without Dysmotility
Authors: Hammar Oskar , Veress Bela , Montgomery Agneta , Ohlsson Bodil
Published: March 2022

Leuprolide is a gonadotropin-releasing hormone (GnRH) analog which has been shown to reduce symptoms in patients with irritable bowel syndrome (IBS) and chronic intestinal pseudo-obstruction (CIPO). The mechanism is not known, but one hypothesis is through down-modulation of luteinizing hormone (LH) secretion, a hormone whith antagonistic effect on gastrointestinal motility. However, presence of LH receptors in the gastrointestinal tract has never been described. The aim of this study was to find one possible way of action for leuprolide by examining the presence of the LH receptor, and if present, to see whether there was different expression in patients with or without dysmotility. Full-thickness biopsies from the bowel wall of patients with and without severe dysmotility were examined using immunohistochemistry staining. Biopsies showed expression of LH receptors on myenteric neurons and in glial cells, neutrophils, endothelial cells and mast cells. There was no difference in expression between patient groups.
Relationships between Symptoms and Signs of Dry Eye Using Symptom Assessment in Dry Eye Questionnaires
Authors: Kim Haram , Oh Guanyeop , Kim Dong Hyun
Published: March 2022

Purpose: To investigate the pattern of Symptom Assessment in Dry Eye (SANDE) questionnaire symptom scores in dry eye disease (DED) patients and to assess the relationships with several dry eye signs.Methods: The medical records of 173 patients with DED were analyzed retrospectively. Each patient’s SANDE score and history of autoimmune disease and ocular surgery were investigated, and Schirmer’s test, tear film breakup time (TBUT), ocular surface staining score (OSS), tear osmolarity, and tear MMP-9 test were assessed. The distribution of SANDE scores and relationships between the SANDE score and various dry eye signs were analyzed. The relationships between the SANDE scores of TBUT (< 5 / ≥ 5) and OSS (< 3 / ≥ 3) subgroups were compared.Results: The average SANDE score was 52.6 ± 28.1. The SANDE scores were significantly higher in OSS ≥ 3 than in OSS < 3 (79.1 ± 21.6 vs. 51.1 ± 27.6, p = 0.030), and TBUT ≥ 5 had marginally significantly lower SANDE scores than TBUT < 5 (47.2 ± 25.6 vs. 55.6 ± 29.0, p = 0.050). TBUT was significantly negatively (R = -0.151, p = 0.024) correlated with the SANDE score, while OSS was marginally significantly positively (R = 0.111, p = 0.073) correlated. As OSS increased, the SANDE scores tended to increase (p for trend = 0.008). Other dry eye signs were not associated with the SANDE score.Conclusions: The DED symptom score from the SANDE questionnaire was related to TBUT and OSS, but there was still a discrepancy between the symptoms and signs of DED.
Clinical Efficacy of Iris Cystostomy Using a Yttrium Aluminum Garnet Laser
Authors: Jo Yeon Ji , Son Yu Bin , Lee Jong Soo
Published: March 2022

Purpose: To report the clinical efficacy of neodymium-doped yttrium aluminum garnet (Nd:YAG) laser iris cystotomy in iris cysts.Methods: We examined three eyes with primary iris cysts diagnosed by ultrasound biomicroscopy that had fewer cornea endothelial cells or reduced visual acuity due to an occluded visual axis. Nd:YAG laser cystotomy was done. The logarithm of the minimum angle of resolution (logMAR) visual acuity, intraocular pressure (IOP), and specular microscopy test at baseline and last follow-up were reviewed.Results: The average patient age was 54.0 ± 5.3 years; the mean follow-up was 11.7 ± 2.1 months. The baseline and final logMAR visual acuity were 0.23 ± 0.25 and 0.16 ± 0.15, respectively. Visual acuity improved, although not significantly (p = 0.317). The baseline and final IOP were 14.7 ± 2.3 and 13.7 ± 0.6 mmHg, respectively (p = 0.276). The corneal endothelial cell density (p = 0.109), hexagonality (p > 0.999), and coefficient of variation (p = 0.285) were not significantly different after treatment. There were no serious complications or recurrence.Conclusions: After Nd:YAG laser cystotomy, the cell density and morphology of corneal endothelial cells changed little. It can be considered an effective treatment when there is a decrease in corneal endothelial cells or occlusion of the visual axis.
Interview with Dr. Shirin Haque, Astronomer and National Outreach Coordinator (IAU) University of the West Indies, Dept of Physics, St Augustine, Trinidad & Tobago
Authors: Berbey Álvarez Aranzazu , Delgado-Serrano Rodney
Published: March 2022

Dr Shirin Haque was born in the village of Patna, India and came to Trinidad at the age of seven without being able to speak English and having no formal education. Dr Haque has pioneered the cutting-edge field of Astrobiology at the University of the West Indies and was interviewed by the BBC for a feature Science in Action for the research on the Pitch Lake, the largest natural hydrocarbon lake in the world. She is the founding member of CARINA (Caribbean Institute of Astronomy) and the founder/CEO of W.I.S.H. (Women In Science for Hope) Foundation. She holds numerous teaching and research awards regionally and internationally. She has also distinguished herself as a film producer with three science documentaries. She has hosted and produced two television series “Exploring our place in the Universe with Dr. Shirin Haque” and “Full S-T-E-A-M Ahead!” She is currently the editor of the magazine “The Intellectual – Art, Science and Architecture”. Her Honours and Awards corresponds to: • Anthony N. Sabga Caribbean Awards for Excellence in Science and Technology 2020• CARICOM Science Award 2018 – first female recipient• Outstanding women of UWI Award – 2018 • Rudranath Capildeo Award for Applied Science and Technology - 2013• “Women in Science and Technology” medal award from NIHERST - 2011• Vice Chancellor’s Award for Excellence in Teaching 2005 - UWI• Distinguished Teacher award from Association of Atlantic Universities - 2004• UWI/ Guardian Life premium teaching award - 2002• “The Most Outstanding Thesis Award, 1997 and 1998” UWI (PhD)• Program Director for the NINE hub programme for the Caribbean through for the National Science foundation and NRAO.
Dr. Reinaldo Espinosa Aguilar: botánico y científico ecuatoriano
Authors: Muñoz Juan Carlos
Published: March 2022

Espinosa investigó y catalogó la flora andina del Ecuador, aportó con estudios sobre la Anatomía y Morfología de las plantas de los Andes ecuatorianos, en relación con el clima, la altura y la presión atmosférica [1]. Su obra se centró en el estudio de la enfermedad llamada “la escoba de la bruja”, que contaminaba el cacao del trópico costeño del Ecuador [2].

    Creó varios herbarios y jardines botánicos en el Ecuador, que hoy por hoy son verdaderos laboratorios experimentales de científicos ecuatorianos, estudiantes del nivel secundario y superior. Implementó un registro de especies herbarias que eran desconocidas, aportando con nuevos registros botánicos, colecciones suyas reposan en los jardines botánicos de Nueva York y Europa, lo que despertó el interés de los botánicos del mundo por estudiar la región sur del Ecuador. Probablemente el máximo representante de la botánica en el Ecuador durante el siglo XX, [3]
Dr. Abel Martiniano del Carmen Bravo Martínez: Ingeniero Civil
Authors: Millán Jiménez Emilia A.
Published: March 2022

Bravo era un visionario que recomendó al Gobierno nacional varios proyectos que tardarían décadas en hacerse realidad: carreteras y ferrocarriles para unir la república, un relleno para la bahía de Panamá con la tierra extraída del Canal, y en las erosionadas tierras que rodeaban las playas de Bella Vista, “un muro de sostenimiento y defensa de unos 350 metros de longitud y a un costo de 80 mil dólares, que vendría a formar parte del proyecto de malecón comenzando en el barrio de la Exposición de esta ciudad”.

Sus dos obras escritas fueron: Programa de Aritmética Analítica y Comercial y Programa de Geometría Plana. Tradujo al castellano y aumentó el Tratado de Algebra Elemental de Benjamin Greenleaf.
Фінансові та матеріальні можливості України щодо забезпечення необхідного рівня розвитку складових елементів воєнно-економічної безпеки
Authors: Semenenko Oleh , Abramova Marina , Voronchenko Ihor , Motrunych Ivan , Pekuliak Roman , Afanasyev Olexandr
Published: March 2022

Мета роботи: визначення та оцінювання рівнів можливостей забезпечення таких складових елементів воєнно-економічної безпеки держави (ВЕБ) як фінансові та матеріальні ресурси, як одного зі шляхів корегування введення державної політики.

Дизайн/Метод/Підхід дослідження: на основі власних спостережень, отриманих результатів з використанням методу експертного опитування та аналізу закордонного досвіду здійснено порівняльне оцінювання результатів за визначеними авторами відношеннями показників до 2021 року включно, що мають вплив на стан фінансових та матеріальних можливостей ВЕБ.

Результати дослідження: розраховано рівні можливостей забезпечення фінансовими та матеріальними ресурсами (воєнно-економічний аспект) економіки до 2021 року включно, що дозволило оцінити не тільки їх поточний стан, а й динаміку за останнє десятиріччя.

Теоретична цінність дослідження: Результатом оцінювання можливостей України щодо забезпечення необхідного рівня розвитку таких складових елементів воєнно-економічної безпеки, як фінансова та матеріальна стали, визначені авторами, граничні межі відповідних показників-відношень. Даний підхід може бути використаний для відображення стану й інших її складових; а представлення результатів у вигляді коефіцієнтів (від “1” до “5”) дозволило суттєво підвищити візуальне сприйняття матеріалу.

Тип статті: аналітичний.
TESTING OF ANTIOXIDANT ACTIVITY ON SEVERAL TYPES OF MONOFLORAL HONEY OF APIS MELLIFERA BEES USING DPPH AND FRAP METHODS
Authors: Aini Siti Nur , Noya Alexander T , Tambun Sabrina Handayani , Susanto Haryanto
Published: March 2022

Senyawa antioksidan dipercaya dapat menghambat terjadinya proses oksidasi dengan mekanisme menghambat proses inisiasi atau propagasi reaksi oksidasi berantai, bahan alam seperti madu dapat digunakan sebagai pembawa senyawa antioksidan. Oleh sebab itu, diperlukannya metode untuk menganalisa aktivitas antioksidan yang selektif untuk menganalisa sampel tersebut. Metode pengujian antioksidan seperti DPPH dan FRAP dibedakan berdasarkan mekanisme reaksinya, sementara pelarut yang digunakan untuk maserasi dipilih berdasarkan sifat kepolarannya. Sampel yang digunakan sebagai standar antioksidan dipilih berdasarkan struktur flavon dan flavonoid yang umumnya mewakili dasar struktur antioksidan bahan alam. Metode uji DPPH ditemukan paling efektif dan efisien dibandingkan dengan metode FRAP dengan nilai IC50ekstrak metanol madu berturut-turut 16,9;33,8;35,7;80,6;83,4;106,7 dan nilai IC50ekstrak N-heksan madu berturut-turut 12,4;14,1;16,4;18,9;29,4;29,7. Kolerasi antara kedua metode uji terbukti sangat tinggi (R>0,95) sehingga diantara keduanya dapat saling menggantikan dalam dilakukannya analisis
PERANCANGAN POSTER MENGENALKAN BUDAYA MA NENE DI TANA TORAJA UNTUK REMAJA USIA 12 HINGGA 24 TAHUN
Authors: Kusumawangi Aprilia
Published: March 2022

Indonesia disebut dengan Negara Budaya karena di Indonesia kaya akan berbagai budaya-budaya yang beraneka ragam, dari banyaknya budaya Indonesia dan semakin modernnya jaman, banyak budaya Indonesia yang dilupakan oleh kalangan anak muda atau remaja saat ini. Makin dikhawatirkannya jika budaya budaya Indonesia jarang ditampilkan atau diperlihatkan sebagai pengingat budaya di kalangan saat ini, budaya yang ada berpuluh puluh tahun bahkan beratus ratus tahun lalu akan punah dengan sendirinya. Salah satunya ialah budaya Ma’Nene di Tana Toraja yang cukup unik alur upacara maupun peristiwanya, yakni membersihkan jasad dan mengganti pakaiannya.

Perancangan poster gerakan sosial bergaya psychedelic adalah salah satu media yang dapat diaplikasikan untuk pengingat budaya. Tak hanya berinovasi baru melainkan juga poster psychedelic dapat masuk ke jaman saat ini terlihat dari jenis gayanya yang menggunakan banyak warna dan membuat target audiens akan berasumsi dan menyimpulkan dari yang mereka lihat.

Dalam proses perancangannya, digunakan metode kualitatif. Metode kualitatif yang digunakan yaitu mencari informasi dari internet maupun dari narasumber yang memang asli Tana Toraja. Metode ini bertujuan untuk mendapatkan data deskriptif yang nantinya akan membantu proses pra produksi yakni pencarian ide dan pembuatan sketsa.

Hasil dari perancangan ini adalah poster digital maupun cetak dalam format JPEG berukuran A1 atau ukuran 59,4 x 84,1 cm yang nantinya akan dipamerkan. Poster ini sendiri berjumlah 6 poster yang dari satu karya ke karya yang lain saling bersangkutan. Selain berupa poster, perancangan ini juga menghasilkan beberapa media pendukung seperti berupa t-shirt, totebag, key chain, smartphone case, notebook cover, maupun Instagram post.
Levels of myosin heavy chain mRNA transcripts and content of protein isoforms in the slow soleus muscle of 7-month-old rats with altered thyroid status
Authors: Vadászová A , Hudecová S , Križanová O , Soukup T
Published: March 2022

Skeletal muscles of small rodents contain four main fiber types, namely type 1, 2A, 2X/D and 2B fibers containing myosin heavy chain (MyHC) 1, 2a, 2x/d and 2b isoforms. Each of these MyHC isoforms is the product of a distinct gene and their expression is believed to be primarily transcriptionally controlled. In most rat muscles, messenger RNA (mRNA) transcripts for MyHC1, 2a, 2x/d and 2b and their corresponding protein products were found with the exception of the soleus muscle, where typically only MyHC1 and 2a transcripts and protein isoforms were demonstrated under normal conditions. Here we show the expression of all four MyHC1, 2a, 2x/d and 2b mRNA transcripts in the soleus muscle under normal conditions in euthyroid, as well as in experimental hypothyroid and hyperthyroid (with the exception of 2b MyHC transcript) 7-month-old female inbred Lewis rats. This is not matched, however, by the appearance of corresponding four isoforms, as we have found that 2x/d and 2b protein isoforms are not present at levels detectable by SDS-PAGE. We also show that the chronic hypothyroid and hyperthyroid status affects the expression of MyHC isoforms both at the mRNA and protein levels.
Seaweeds: Bioactive Components and Properties, Potential Risk Factors, Uses, Extraction and Purification Methods
Authors: AMLANI Merilyn , YETGİN Senem
Published: March 2022

Seaweeds, also known as macroalgae, are abundant sources of various vital bioactive components with a wide range of biological functions. They are sold commercially and are primarily used in the food industry, pharmaceuticals, cosmeceuticals, and other related industries. The diverse biological activities linked with bioactive compounds obtained from seaweeds have the potential to expand their health benefit value in the food and pharmaceutical industries. Studies revealed that seaweeds have the potential to be used as complementary medicine due to its variety of biological properties that have been shown to be therapeutic for health and disease management, such as antibacterial, anticoagulant, anticancer, antidiabetic, antiestrogenic, antihypertensive, antihyperlipidemic, antifungal, anti-inflammatory, antioxidant, antiobesity, antiviral, immunomodulatory, neuroprotective, thyroid stimulant, tissue healing properties, and many more. Although seaweeds are generally beneficial to humans, they may still pose possible health risks due to high iodine concentration and exposure to heavy metals and arsenic concentrations. However, information on this topic is still limited. With the great importance of seaweeds, various green extraction methods such as Microwave-assisted Extraction (MAE), Supercritical Fluid Extraction (SFE), Pressurized Solvents Extraction (PSE) and Enzyme-ssisted Extraction (EAE) were used as an alternative to the conventional method to isolate bioactive components and further purified using chromatographic technique analysis to ensure the purity of the extract. This review covers the following topics: general structure and characteristics of seaweeds, seaweed production, bioactive components and properties of seaweed, possible risk factors of seaweeds, applications of seaweeds, extraction, and purification of seaweed extracts.
La Joëlette como herramienta de inclusión. Revisión de la literatura.
Authors: Hernández-Beltrán Víctor , Gámez-Calvo Luisa , Rojo-Ramos Jorge , Gamonales José M.
Published: March 2022

El objetivo de la presente investigación fue valorar el senderismo con Joëlette como medio de inclusión de las personas con discapacidad. Para ello, se llevó a cabo una revisión de la literatura existente relacionada con el uso de la Joëlette en las personas con discapacidad en diferentes bases de datos (Google Scholar, Dialnet y Web of Science). Para refinar la búsqueda, se establecieron unos criterios de inclusión y exclusión de los documentos, obteniéndose así un número de cinco documentos finales. Como resultado, se obtiene que es necesario una mayor investigación al respecto debido a la falta de concienciación de la población y dar a conocer otro tipo de deporte inclusivo. La documentación seleccionada es escasa, por lo que se deben llevar a cabo otras investigaciones y promover este tipo de deportes en personas con discapacidad.
Diseño y validación del cuestionario sobre creencias y valores implícitos entre alumnado y profesorado (CVIAP) en la interacción de la clase de educación física.
Authors: Guerrero-Soto Jesus Arturo Arturo , Medina-Valencia Rossana Tamara , Andrade-Sánchez Adriana Isabel
Published: March 2022

El objetivo del presente artículo fue diseñar y validar un instrumento que permita definir las percepciones de alumnado y profesorado sobre las interacciones, actitudes y valores que se enseñan, aprenden y promueven en la práctica educativa de la clase de educación física. Se trató de un estudio descriptivo transversal; la encuesta construida (CVIAP) pasó por seis fases, que incluyó pilotaje en un grupo no probabilístico de alumnos y profesores, jueceo de expertos y grupos de discusión. El cuestionario constó de 35 ítems en escala de Likert que miden cinco constructos latentes, se hicieron las valoraciones cuantitativas y cualitativas para ajustar los ítems. Los hallazgos arrojan información objetiva sobre cómo los alumnos interactúan y valoran el trabajo docente y viceversa. La validación del instrumento revela datos confiables sobre dichas percepciones y se concluye que permite indagar sobre estas creencias entre alumnado y profesorado para investigaciones futuras.
El desplazamiento activo a los entrenamientos en jugadores/as de baloncesto en Extremadura
Authors: Cerro Herrero David , Moreno Díaz María Isabel , Tapia Serrano Miguel Ángel , Prieto Prieto Josué
Published: March 2022

ResumenEl desplazamiento activo hace referencia a la acción de dirigirse al centro educativo o al lugar de trabajo por medio de transportes que conlleven un gasto energético como andar o ir en bicicleta (Ruíz-Ariza, Torre-Cruz, Redecillas-Peiró, y Martínez-López, 2015); acto que va en relación con la actividad física y sus beneficios para la salud (Cuberos, Giráldez, Zagalaz, Sánchez y García, 2016). Por ello, el presente estudio tiene como objetivo principal conocer los hábitos de movilidad de deportistas de nivel profesional o semiprofesional, además se plantea como segundo objetivo conocer los motivos que tienen mayor influencia a la hora de seleccionar el medio de desplazamiento a los entrenamientos por parte de jugadores y jugadoras de baloncesto en Extremadura. Se trata de un estudio de tipo transversal, cuantitativo y una selección de la muestra por conveniencia, la cual fue de 73 jugadores/as de baloncesto federados de ligas de nivel nacional y regional de la Comunidad Autónoma de Extremadura (30,1% de género femenino y 69,9% masculino), de edades comprendidas entre 17 y 44 años, siendo la edad media de los participantes 23 años. Los resultados mostraron que el medio de transporte más utilizado por los jugadores y jugadores de baloncesto es el automóvil con un 64.1% a la ida al entrenamiento y un 68.5% a la vuelta. Por tanto, la presente investigación concluye que es necesario generar campañas para fomentar el desplazamiento activo entre los deportistas ya que estos pueden ser un buen ejemplo para otros colectivos (niños y jóvenes).
Análisis de la actividad física en estudiantes de educación física con sobrepeso y obesidad durante la pandemia por COVID-19
Authors: Hall López Javier Arturo , Ochoa-Martínez Paulina Yesica , Martínez López Emilio José , Hernandez Armas Esteban , Miranda Botelho Teixeira Ana Maria
Published: March 2022

La pandemia por COVID-19, ha limitado de manera súbita la práctica de actividad física, dentro de los entornos escolares el profesorado de educación física puede medir conductas sedentarias con la intención de minimizarlas en los grupos más vulnerables. El objetivo del estudio fue analizar la actividad física en estudiantes de educación física comparando dos grupos en función de su índice de masa corporal durante 6 meses del distanciamiento social derivado de la pandemia por COVID-19. Los participantes fueron 167 estudiantes de educación primaria de quinto y sexto grado con una edad media de 10.8±1.6 años (83 hombres y 84 mujeres), quienes fueron evaluados mediante el cuestionario de comportamiento de movimiento (MBQ) en niños en el distanciamiento social durante el primer y sexto mes de la pandemia por COVID-19, los sujetos participantes divididos en dos grupos de acuerdo a su estado nutricio. Los resultados, al ser analizados con el test t-Student para muestras relacionadas no reportaron diferencias significativas en los valores promedio de actividad física moderada vigorosa, ligera y sedentaria dl estudiantado con peso bajo y normal, comparado como el estudiantado con sobrepeso y obesidad. Como conclusión, previo a la pandemia por COVID-19, el estado de la cuestión reporta mayores conductas sedentarias en el estudiantado con sobrepeso y obesidad, aun sin embargo en los sujetos evaluados muy probable mente las condiciones de confinamiento afecto la práctica regular de actividad física.
Mindfulness, Drumming, “Imagen Guiada con Música” y “Yoga” como recursos educativos para minimizar la ansiedad ante los exámenes. Propuesta didáctica en Educación Primaria
Authors: Pascual Gutierrez Patricia , Cortón de las Heras Maria de la O
Published: March 2022

La ansiedad ante los exámenes es una problemática actual dentro de las aulas, que da lugar a secuelas sociales, físicas y psicológicas en los alumnos que lo padecen. El objetivo de este documento es solventar dicho trastorno a través de implementación de diversas actividades de elaboración propia, basadas en técnicas de expresión de emociones como Mindfulness o propias del área de Educación Física y Educación Artística. Sin embargo, no se han podido extraer numerosas conclusiones debido a la actual situación de la Covid-19 que ha provocado que no se haya podido implementar en el aula. A pesar de ello, como resultado principal del proyecto se extrae la importancia de trabajar en el aula dicha problemática para que en futuros cursos los alumnos puedan controlar los síntomas y reducir así la incidencia de dicho trastorno.
Angiogenesis, Metabolism, Endothelial and Platelet Markers in Diabetes and Cardiovascular Disease
Authors: Blann A. D. , Brown J. E. , Heitmar R.
Published: March 2022

Introduction: Diabetes is a leading risk factor for cardiovascular disease (CVD), the pathophysiology of both being linked to metabolic, endothelial, renal, angiogenic and platelet abnormalities. We hypothesised that abnormalities in these systems are more adverse in those whose CVD is compounded by diabetes, compared to those with diabetes or CVD alone.

Materials and methods: Serum or plasma from 66 patients with diabetes alone, 76 with CVD alone, and 70 with both diabetes and CVD i.e. diabetic cardiovascular disease, was probed for markers of angiogenesis [angiopoietin 1 and 2, vascular endothelial growth factor (VEGF) and endoglin], metabolic [soluble receptor for advanced glycation products (sRAGE), leptin, lipocalin-2, interleukin-8, and cystatin-C], the endothelium (von Willebrand factor, endothelial microparticles and soluble E selectin)], and the platelet (platelet microparticles and soluble P selectin) by ELISA, Luminex or flow cytometry.

Results: VEGF (p = 0.04), von Willebrand factor (p = 0.001) and endothelial microparticles (p = 0.042) were all higher in diabetic cardiovascular disease than in diabetes alone and cardiovascular disease alone. Soluble E selectin was higher in diabetic cardiovascular disease than in diabetes alone (p = 0.045), whilst cystatin-C (p = 0.004) and soluble P selectin (p < 0.001) were higher in diabetes and diabetic cardiovascular disease than in cardiovascular disease alone. There were no differences in angiopoietin 1 or 2, endoglin, sRAGE, leptin, lipocalin-2, or interleukin-8.

Conclusion: Angiopoietin 1 or 2, endoglin, sRAGE, leptin, lipocalin-2, interleukin-8, and cystatin-c cannot differentiate diabetes from cardiovascular disease, or both conditions combined. Our data point to a more adverse endothelial (von Willebrand factor, endothelial microparticles), and angiogenic profile (VEGF) in those with diabetic cardiovascular disease, supporting the view that this group should be targeted more aggressively.
Artificial Intelligence Advancements in the Cardiovascular Imaging of Coronary Atherosclerosis
Authors: Covas Pedro , De Guzman Eison , Barrows Ian , Bradley Andrew J. , Choi Brian G. , Krepp Joseph M. , Lewis Jannet F. , Katz Richard , Tracy Cynthia M. , Zeman Robert K. , Earls James P. , Choi Andrew D.
Published: March 2022

Coronary artery disease is a leading cause of death worldwide. There has been a myriad of advancements in the field of cardiovascular imaging to aid in diagnosis, treatment, and prevention of coronary artery disease. The application of artificial intelligence in medicine, particularly in cardiovascular medicine has erupted in the past decade. This article serves to highlight the highest yield articles within cardiovascular imaging with an emphasis on coronary CT angiography methods for % stenosis evaluation and atherosclerosis quantification for the general cardiologist. The paper finally discusses the evolving paradigm of implementation of artificial intelligence in real world practice.
Biological Characteristics and Predictive Model of Biopsy-Proven Acute Rejection (BPAR) After Kidney Transplantation: Evidences of Multi-Omics Analysis
Authors: Han Qianguang , Zhang Xiang , Ren Xiaohan , Hang Zhou , Yin Yu , Wang Zijie , Chen Hao , Sun Li , Tao Jun , Han Zhijian , Tan Ruoyun , Gu Min , Ju Xiaobing
Published: March 2022

Objectives: Early diagnosis and detection of acute rejection following kidney transplantation are of great significance for guiding the treatment and improving the prognosis of renal transplant recipients. In this study, we are aimed to explore the biological characteristics of biopsy-proven acute rejection (BPAR) and establish a predictive model.

Methods: Gene expression matrix of the renal allograft samples in the GEO database were screened and included, using Limma R package to identify differentially expressed transcripts between BPAR and No-BPAR groups. Then a predictive model of BPAR was established based on logistic regression of which key transcripts involved in the predictive model were further explored using functional enrichment analyses including Gene Ontology analysis (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and Gene Set Enrichment Analysis (GSEA).

Results: A total of four studies (GSE129166, GSE48581, GSE36059, and GSE98320) were included for extensive analysis of differential expression. 32 differential expressed transcripts were observed to be significant between two groups after the pooled analysis. Afterward, a predictive model containing the five most significant transcripts (IDO1, CXCL10, IFNG, GBP1, PMAIP1) showed good predictive efficacy for BPAR after kidney transplantation (AUC = 0.919, 95%CI = 0.902–0.939). Results of functional enrichment analysis showed that The functions of differential genes are mainly manifested in chemokine receptor binding, chemokine activity, G protein-coupled receptor binding, etc. while the immune infiltration analysis indicated that immune cells mainly related to acute rejection include Macrophages. M1, T cells gamma delta, T cells CD4 memory activated, eosinophils, etc.

Conclusion: We have identified a total of 32 differential expressed transcripts and based on that, a predictive model with five significant transcripts was established, which was suggested as a highly recommended tool for the prediction of BPAR after kidney transplantation. However, an extensive study should be performed for the evaluation of the predictive model and mechanism involved.
Effects of Dimethyl Fumarate on Brain Atrophy in Relapsing-Remitting Multiple Sclerosis: Pooled Analysis Phase 3 DEFINE and CONFIRM Studies
Authors: Nakamura Kunio , Mokliatchouk Oksana , Arnold Douglas L. , Yousry Tarek A. , Kappos Ludwig , Richert Nancy , Ayling-Rouse Katherine , Miller Catherine , Fisher Elizabeth
Published: March 2022

Objective

In the pivotal DEFINE and CONFIRM trials for dimethyl fumarate (DMF), patterns of brain volume changes were different, potentially due to low sample sizes and because MRIs were analyzed at two different reading centers. We evaluated effects of DMF on brain volume change in patients with multiple sclerosis (MS) through reanalysis of pooled images from DEFINE/CONFIRM trials in one reading center.

Methods

MRIs from DEFINE/CONFIRM at weeks 0, 24, 48, and 96 from patients randomized to twice-daily DMF or placebo (PBO) were reanalyzed at the Cleveland Clinic to measure brain parenchymal fraction (BPF). To account for pseudoatrophy, brain volume estimates were re-baselined to calculate changes for weeks 48–96.

Results

Across studies, 301 and 314 patients receiving DMF and PBO, respectively, had analyzable MRIs. In weeks 0–48, mean ± SE percentage change in BPF was −0.44 ± 0.04 vs. −0.34 ± 0.04% in DMF vs. PBO, respectively, whereas in weeks 48–96, mean ± SE percentage change in BPF was −0.27 ± 0.03 vs. −0.41 ± 0.04% in DMF vs. PBO, respectively. The mixed-effect model for repeated measures showed similar results: in weeks 48–96, estimated change (95% confidence interval) in BPF was −0.0021 (−0.0027, −0.0016) for DMF vs. −0.0033 (−0.0039, −0.0028) for PBO (35.9% reduction;p= 0.0025).

Conclusions

The lower rate of whole brain volume loss with DMF in this pooled BPF analysis in the second year vs. PBO is consistent with its effects on relapses, disability, and MRI lesions. Brain volume changes in the first year may be explained by pseudoatrophy effects also described in other MS clinical trials.
Dynamical Complexity Fingerprints of Occupation-Dependent Brain Functional Networks in Professional Seafarers
Authors: Yan Hongjie , Wu Huijun , Chen Yanyan , Yang Yang , Xu Min , Zeng Weiming , Zhang Jian , Chang Chunqi , Wang Nizhuan
Published: March 2022

The complexity derived from resting-state functional magnetic resonance imaging (rs-fMRI) data has been applied for exploring cognitive states and occupational neuroplasticity. However, there is little information about the influence of occupational factors on dynamic complexity and topological properties of the connectivity networks. In this paper, we proposed a novel dynamical brain complexity analysis (DBCA) framework to explore the changes in dynamical complexity of brain activity at the voxel level and complexity topology for professional seafarers caused by long-term working experience. The proposed DBCA is made up of dynamical brain entropy mapping analysis and complex network analysis based on brain entropy sequences, which generate the dynamical complexity of local brain areas and the topological complexity across brain areas, respectively. First, the transient complexity of voxel-wise brain map was calculated; compared with non-seafarers, seafarers showed decreased dynamic entropy values in the cerebellum and increased values in the left fusiform gyrus (BA20). Further, the complex network analysis based on brain entropy sequences revealed small-worldness in terms of topological complexity in both seafarers and non-seafarers, indicating that it is an inherent attribute of human the brain. In addition, seafarers showed a higher average path length and lower average clustering coefficient than non-seafarers, suggesting that the information processing ability is reduced in seafarers. Moreover, the reduction in efficiency of seafarers suggests that they have a less efficient processing network. To sum up, the proposed DBCA is effective for exploring the dynamic complexity changes in voxel-wise activity and region-wise connectivity, showing that occupational experience can reshape seafarers’ dynamic brain complexity fingerprints.
Mitochondrial Reactive Oxygen Species Mediate Activation of TRPV1 and Calcium Entry Following Peripheral Sensory Axotomy
Authors: Kievit Bradley , Johnstone Aaron D. , Gibon Julien , Barker Philip A.
Published: March 2022

Axons that are physically separated from their soma activate a series of signaling events that results in axonal self-destruction. A critical element of this signaling pathway is an intra-axonal calcium rise that occurs just prior to axonal fragmentation. Previous studies have shown that preventing this calcium rise delays the onset of axon fragmentation, yet the ion channels responsible for the influx, and the mechanisms by which they are activated, are largely unknown. Axonal injury can be modeled in vitro by transecting murine dorsal root ganglia (DRG) sensory axons. We coupled transections with intra-axonal calcium imaging and found that Ca2+ influx is sharply reduced in axons lacking trpv1 (for transient receptor potential cation channel vanilloid 1) and in axons treated with capsazepine (CPZ), a TRPV1 antagonist. Sensory neurons from trpv1–/– mice were partially rescued from degeneration after transection, indicating that TRPV1 normally plays a pro-degenerative role after axonal injury. TRPV1 activity can be regulated by direct post-translational modification induced by reactive oxygen species (ROS). Here, we tested the hypothesis that mitochondrial ROS production induced by axotomy is required for TRPV1 activity and subsequent axonal degeneration. We found that reducing mitochondrial depolarization with NAD+ supplementation or scavenging ROS using NAC or MitoQ sharply attenuates TRPV1-dependent calcium influx induced by axotomy. This study shows that ROS-dependent TRPV1 activation is required for Ca2+ entry after axotomy.