bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving The Quality of Sanitation in The Popcorn Production Process at UMKM Ziqma Production
Authors: Putra Andre yusuf trisna , Kurnianto Muhammad Alfid
Published: June 2024

Ziqma Production is an Micro, Small Medium Enterprise (MSME) that produces snacks with a superior product, popcorn. The pop corn production process at Ziqma is still simple and does not yet implement quality control management and food safety. Therefore, the aim of this activity is to provide education about implementing sanitation to improve the quality of the production process. This program was implemented on August 3 2023. The activities consist of three stages, namely coordination with partner, counseling about CPPOB principles, and implementation of the use of production sanitation equipment according to Cara Produksi Pangan Olahan yang Baik (CPPOB) principles. The result of this activity is that Zigma workers know the theory about sanitation. Apart from that, be able to use sanitary equipment, such as aprons, masks, gloves and head coverings. It is hoped that after this activity, all workers can implement sanitation so that the quality of popcorn products can be maintained.
EDITORIAL: Los Actos Procesales en la Resolución eficaz del Derecho
Authors: Vivanco Granda Estefanía Cristina
Published: June 2024

Los actos procesales en la resolución eficaz del Derecho compilan trabajos de diferentes juristas ecuatorianos y un autor argentino que aportan con aspectos relevantes del derecho que deben ser analizados. Se empieza por la legislación argentina. El tax compliance se presenta como un modelo dinámico de adopción voluntaria. Actualmente, este constituye una herramienta esencial para las empresas. Todo gracias a que este mecanismo ayuda a prevenir, detectar y gestionar los riesgos tributarios empresariales, independientemente del tamaño del ente. A continuación, se analiza la implementación de la figura de la carga dinámica de la prueba en procesos judiciales originados por conflictos societarios a partir de Ley reformatoria a la Ley de Compañías para la Optimización e Impulso Empresarial y para el Fomento del Gobierno Corporativo. Después, se examina el criterio adoptado por la Corte Constitucional en relación con la declaración de vulneración de los derechos a la seguridad jurídica y al debido proceso, debido a la falta de un pronunciamiento sobre el fondo del recurso de casación. También se revisa el principio de celeridad procesal que indaga el propósito de asegurar la pronta resolución de los litigios vinculados a la ejecución. Finalmente, se reflexiona sobre la necesidad de regular el derecho de alimentos, para las nuevas situaciones sociales como la maternidad subrogada o vientres de alquiler.
A preliminary study of the pteridophytes, gymnosperms, And monocotyledons in the chapainawabganj district's flora of bangladesh
Authors: Islam Muhammad Shahidul , Khan Saleh Ahammad
Published: June 2024

This study demonstrates that the vascular flora (Pteridophytes, Gymnosperms, and Monocotyledons) of the Chapainawabganj district area consists of 247 species with two subspecies under 126 genera and 35 families. The pteridophytes and gymnosperms are represented by 19 and four species, respectively, whereas the monocotyledons (Liliopsida) are represented by 224 species. Poaceae, with 91 species, representing 36.84% of the flora, appears to be the largest family, followed by Cyperaceae 32, Araceae 19, Asparagaceae 12, and Arecaceae 11, which collectively constitute ca. 30% of this flora. Cyperus, comprising 18 species, is recorded as the largest genus, followed by Fimbristylis, Digitaria, Panicum, Bambusa, Urochloa, Dracaena, and Dioscorea. About 87.55% of this flora’s taxa are herbs, 4.42% are palms, 3.61% are shrubs, and the rest are bamboos and trees. Erect herbs, forming 61.04% of the flora, comprise the most common life form. In this flora, almost 74.30% of the taxa are native, and the rest, 25.70%, are exotic. It is found that nearly 74.70% of the taxa are wild, 14.06% are planted, and 11.24% are cultivated. About 23.29% of taxa commonly occur throughout all upazilas in this district. Most of the species are harboured in fallow lands, roadsides, gardens, and homesteads. All species of this district's flora are known to be economically useful. Most of its habitats and ecosystems are exposed to different threats. Adequate measures with effective management plans should be adopted and implemented for the sustainable use, improvement, and conservation of this precious flora.
Bangladesh J. Plant Taxon. 31(1): 83-99, 2024 (June)
New combinations in primula sect. Cortusoides subsect. Cortusa (primulaceae)
Authors: Idrees Muhammad , Zhang Zhiyong , Shaw Julian M H
Published: June 2024

Abstract not available.
Bangladesh J. Plant Taxon. 31(1): 177-180, 2024 (June)
Isolation and Characterization of Polyprenols from Litsea monopetala (Roxb.) Pers.
Authors: Kamal Mir Shahriar , Ashrafi Sania , Sultana Sara , A Rashid Mohammad , Ahsan Monira , Masud Mohammad Mehedi , Haque Mohammad Rashedul
Published: June 2024

Litsea monopetala (Roxb.) Pers. (Family: Lauraceae) is a plant that holds substantial ethnobotanical significance due to its traditional and cultural importance. In this study, we conducted an extensive chemical investigation on L. monopetala, a plant native to the regions including Nepal, India, and Bangladesh. Two unique secondary metabolites were isolated and characterized from ethyl acetate (EtOAc) extract of the leaves of L. monopetala which were identified as tri-trans poly-cis prenol-15 (1), and its acetylated derivative tri-trans poly-cis prenol-15 (2). The structures of the isolated compounds were determined through in-depth analysis of their highresolution 1H NMR, 13C NMR, COSY, HSQC, and HMBC spectroscopic data, along with comparison to existing published data. Both the compounds are isolated from the plant for the first time. Further studies are recommended to analyze the potential bioactivity associated with the molecules.
Dhaka Univ. J. Pharm. Sci. 23(1): 63-68, 2024 (June)
Calcium Imbalance and Hypothyroidism: Exploring the Relationship
Authors: Sultana Sabera , Mosammad Alpana Jahan  , Syed Minhaj Uddin Ahmed  , Rabeya Sultana  , Fatema Ferdous Ara
Published: June 2024

Background: The thyroid gland synthesizes mainly two hormones, triiodothyronine (T3) and thyroxin (T4) which are important to maintain various functions especially metabolic, mineral and thermogenic homeostasis in body. The disorders of thyroid function especially hypothyroidism is important it can cause of disturbance in calcium metabolism by their direct action on bone turnover.Objective: This study was designed to assess the role of hypothyroidism in serum calcium levels.Materials and Methods: This case-control study was done in the Laboratory Service Department, Khwaja Yunus Ali Medical College and Hospital, Enayetpur, Sirajganj from February 2023 to June 2023. A total of 45 subjects of hypothyroidism of both sexes were selected for the purpose. Data were collected in and analysis was done by IBM SPSS Statistics for Windows, version 23.0 (IBM Corp., Armonk, N.Y., USA) software. The categorical variables were represented as percentages and measurable variables as mean ± SD. Pearson’s correlation test was used to observe the correlation of calcium level with other variables. P value ≤ 0.05 was considered to be statistically significant.Results: There is a significant positive correlation of serum T3 & T4 with serum calcium in hypothyroid patients. The r value is +0.73(p value = 0.02). (r value + 0.78and p value < 0.05) respectively. There is strong negative correlation between TSH and serum calcium levels in hypothyroid patients (r value -0.58 and p value0.03).Conclusion: This study result shows, serum calcium levels significantly decrease in hypothyroid patients. Therefore, it is important to check the level of calcium in thyroid disorders. If necessary, the supplementation of mineral should be given in order to prevent further bone complication.
KYAMC Journal Volume: 14, No: 04, January 2024: 194-197.
Assessment of Factors and Level of Patient Satisfaction in Out-patient Department of a Private Hospital
Authors: Ashraf Uddin Mallik  , Rubaiyat Farzana Hussain  , Md Mostafizur Rahman  , Uttam Karmaker  , Tamanna Jahan  , Marufur Rahman  , Imtiaz Ahmed  , Dilruba Hossain Dolon  , Nura Shaharia Mila  , Joyasree Roy Swarna  , Yeasir Arafat Samrat
Published: June 2024

Background: Measurement of patient satisfaction in the outpatient department (OPD) of a hospital can be used to evaluate and redesign the process of caregiving and to improve the quality of services. Sometimes study findings depend on the setting.Objectives: a) To identify the factors associated with the patient's experience, and satisfaction about health care services of Out-patient department(OPD) of Khwaja Yunus Ali Medical College Hospital receives multidisciplinary health services. b) To measure the satisfaction level regarding doctors, health assistance, and other auxiliary staff working in OPD to help patients.Materials and Methods: A cross-sectional study was conducted among 914 patients of age ranging from 1 to 80 years selected randomly from OPD between January 2021 and May 2021. A self-designed semi-structured questionnaire was developed to assess patients' satisfaction with health care services. Statistical analysis was done by online computer software.Results: Overall 92.23 % of the patients were satisfied with the behaviour of the doctors and 75.93 % were satisfied with the services of other staff, and the remaining 7.77% were unsatisfied with doctors' behaviour and 24 % with other staff services respectively.Conclusions: The percentages of unsatisfied patients were deficient. Various deficiencies should always be covered by the hospital administration that will turn into a good result of improvement in the hospital services for more satisfaction of the patients.
KYAMC Journal Volume: 14, No: 04, January 2024: 234-239.
Tinjauan Guru Tentang Evaluasi Perkembangan Motorik Halus Selama Pembelajaran Daring Di Kelompok B Se-Gugus Asparagus Kota Bengkulu
Authors: Surbakti Putri Feni Ayu Mutiara , SS Sri Saparahayuningsih , Daryati Melia Eka
Published: June 2024

Tujuan penelitian ini adalah untuk mendeskripsikan apakah tinjauan guru tentang evaluasi perkembangan motorik halus selama pembelajaran daring pada kelompok B Se-Gugus Asparagus Kota Bengkulu. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis metode deskriptif survei. Populasi dalam penelitian ini adalah guru yang berada di Pendidikan Anak Usia Dini Se-Gugus Asparagus Kota Bengkulu yang berjumlah 30 orang guru. Penentuan sampel dalam penelitian ini menggunakan nonprobability sampling total, dimana semua anggota populasi digunakan sebagai sampel yang berjumlah 30 orang guru se-gugus Asparagus Kota Bengkulu. Data penelitian ini dikumpulkan dengan menggunakan angket atau kuisioner. Data yang terkumpul dianalisis menggunakan analisis statistik dengan rumus rata-rata. Hasil penelitian secara umum disimpulkan bahwa terdapat tiga tinjauan guru terhadap hasil evaluasi perkembangan motorik halus di kelompok B yang dilakukan selama pembelajaran daring dan dikategorikan sering, meliputi perencanaan evaluasi, pelaksanaan evaluasi dan laporan hasil evaluasi. Saran penelitian ini yaitu disarankan kepada guru-guru untuk dapat selalu meninjau evaluasi perkembangan motorik halus selama pembelajaran daring secara berskala. Saran bagi peneliti selanjutnya disarankan untuk meneliti lebih lanjut tentang perencanaan evaluasi perkembangan motorik halus selama pembelajaran daring, dan juga dalam melakukan evaluasi perkembangan motorik halus tetap menerapkan lima tahapan evaluasi secara keseluruhan.
Implementasi Media Pembelajaran Magic Hour Untuk Meningkatkan Motorik Halus Anak Usia Dini Kelompok B Di Ra Nurul Hikmah Lenteng Proppo Pamekasan
Authors: Siti Rohmah , Siti Rohmah
Published: June 2024

Undang-undang nomor 20 tahun 2003 tentang sistem pendidikan nasional pasal 1 angka 14 menyatakan bahwa, pendidikan anak usia dini adalah suatu upaya pembinaan yang ditujukan kepada anak sejak lahir sampai dengan usia enam tahun. Anak usia dini memiliki potensi besar untuk mengoptimalkan segala aspek perkembangan fisik motorik. Masa usia dini adalah masa emas perkembangan anak dimana semua aspek perkembangan dapat dengan mudah distimulasi. Media pembelajaran mempunyai peran yang penting dalam proses kegiatan belajar mengajar. Ada lima ranah perkembangan yang dapat distimulasi kepada anak supaya dapat dikembangkan secara maksimal. Peneliti fokus pada ranah perkembangan fisik motorik halus. Adapun tujuan dari penelitian ini adalah  untuk mengetahui bagaimana Implementasi Magic Hour dapat meningkatkan perkembangan Motorik Halus anak usia dini kelompok B di RA Nurul Hikmah Lenteng Proppo Pamekasan. Penelitian ini menggunakan metode deskriptif kualitatif. Adapun metode pengumpulan data yang digunakan dalam penelitian ini yaitu menggunakan metode observasi, wawancara dan dokumentasi. Sumber data primer dalam penelitian ini adalah guru kelas kelompok B dan wali murid kelompok B. Sedangkan sumber data sekunder, peneliti menggunakan buku-buku refrensi, dan dokumentasi kegiatan anak saat di sekolah. Hasil dari penelitian ini menurut hasil wawancara dan observasi menunjukkan Implementasi Media Pembelajaran Magic Hour Untuk Meningkatkan Motorik Halus Kelompok B di RA Nurul Hikmah Lenteng Proppo Pamekasan dapat meningkatkan perkembangan motorik halus anak kelompok B di RA Nurul Hikmah Lenteng Proppo Pamekasan.
TANZİMAT DÖNEMİ MADEN POLİTİKASINDA YER ALAN İLTİZAM ŞİRKETE BİR ÖRNEK: SARIYER BAKIR (NUHAS) MADENİ KUMPANYASI VE SERMAYEDARLARI
Authors: Erdem Sevim
Published: June 2024

İstanbul civarında ve Boğaziçi’nin Rumeli sahilinde bulunan Sarıyer bakır madeni asırlar öncesine dayanan bir geçmişe sahiptir. Osmanlı Devleti döneminde işletilen maden, halkın ve devletin ihtiyaçlarının karşılanmasında önemli roller üstlenmiştir. İstanbul (Dersaadet)’a yakın olması bu madenin aktif olarak kullanılmasını sağlamıştır. 18. Yüzyılda Sarıyer bakır madeni, Tophane-i Amire’deki ocaklıklarda hammadde olarak kullanılırken, 1840’lı yıllara gelindiğinde madenin verimliliğinde azalma görülmüştür. Bir süre Tersane-i Amire tarafından işletilen maden, sonrasında atıl kalma tehlikesiyle karşı karşıya kalmıştır. Sarıyer bakır madeni 1841-1862 yılları arasında Kumpanya usulü ile işletilmiştir.
Sarıyer Bakır Madeni Kumpanyası’nın kuruluşunda, toplam hisse sayısı yüz olarak belirlenmiştir ve hisseler ilan yoluyla satışa çıkarılmıştır. Hisse senetlerinin her birinin değeri iki bin kuruştur, ilk yarısı peşin ikinci yarısı gerektiğinde ödenmek üzere iki taksitle satışa sunulmuştur. Hisse sahiplerine geniş bir işlem olanağı sağlanmış; hisselerini devredebilme, borçlarına karşılık gösterebilme, aileye veya akrabaya miras bırakabilme imkânı sağlanmıştır. Kumpanyanın sermayedarları, devletin hariciye, maliye, ticaret ve gümrük gibi birimlerinde görev yapan üst düzey memurlardan oluşmuştur. Kumpanyanın sermayedarları, bakır işinden ticaretinden anlayan kişiler değildi. Devlet bakır madenini çıkarma, işleme, nakletme ve satış gibi işleri yürütmek üzere mültezimlere verecektir. Mültezim, hissedarlardan mürekkep umumi bir heyet tarafından seçilmiş değildir. Devlet, sermaye sahiplerinin iradesini tecelli ettirme vazifesini üzerine almıştır. İltizam Şirket modelinde temel iki taraf bulunmaktadır. Taraflardan biri maden işinden anlayan mültezim diğeri ise sermayedardır. Bu makalede Tanzimat dönemi maden işletme politikasında yer alan İltizam Şirket konusunun Sarıyer Bakır Madeni Kumpanyası özelinde nasıl uygulandığı, atıl durumda kalmak üzere olan Sarıyer bakır madeninin aktif hale getirilmesi ve bakır madeninin devlet ve sermayedar ekonomisine kazandırılması çabası ele alınmıştır.
Eşya Müsaderesinin Olumsuz Koşulu: Eşyanın İyiniyetli Üçüncü Kişiye Ait Olmaması
Authors: Giyik Abdulbaki
Published: June 2024

Eşya müsaderesi, normal koşullarda, fail veya şeriklerin eşyalarına yönelik olarak uygulanabilen bir ceza hukuku yaptırımıdır. Ancak kanun koyucu, TCK m. 54 hükmünde, iyiniyetli olmayan üçüncü kişilerin eşyalarının da müsadere edilebileceğini belirterek bu kurala önemli bir istisna getirmiştir. Çalışmada, eşya müsaderesinin olumsuz nitelikteki bu koşulu, öğretideki görüşlerden ve Yargıtay’ın konuya ilişkin kararlarından hareketle incelemeye tabi tutulmuştur. Bu kapsamda; eşya müsaderesinin hukukî niteliği ortaya konulmuş, inceleme konumuzu teşkil eden şarta Kanun’da yer verilmesinin gerekli olup olmadığı tartışılmış, TCK m. 54 hükmünün formülasyonuna ilişkin çeşitli eleştirilere yer verilmiş ve son olarak iyiniyetli üçüncü kişilere ait olmamak biçimindeki şartın içeriğine ilişkin hususlarda ayrıntılı açıklamalar yapılmıştır. Bahsi geçen koşulla ilgili tartışmalar yapılırken, ceza hukukunun temel kaideleri de göz önünde bulundurulmuş ve Kanun’da bu şarta yer verilmesinin doğurduğu teorik problemler hakkında çeşitli çözüm önerileri dile getirilmeye çalışılmıştır.
Aşı Nedeniyle Özellikle COVID-19 Aşısı Sonrasında Ortaya Çıkan Zarardan İdarenin Sorumluluğu
Authors: Paksoy Meliha Sermin , Kağıtcıoğlu Mutlu
Published: June 2024

Aşı uygulamalarında idarenin sorumluluğu, COVID-19 salgını sonrasında daha da önem kazanmış bir konudur. İdarenin kolluk faaliyeti içerisinde değerlendirdiğimiz aşı uygulamalarına dair hukuki altyapı ülkelere göre değişiklik göstermektedir. Türkiye’de aşı uygulamalarına dair temel bir mevzuatın olmayışı, zorunlu aşı uygulaması ve aşıdan doğan sorumluluk açısından farklı hukuki problemler ortaya çıkarmaktadır. Anayasa Mahkemesi’nin bu konudaki bireysel başvuru kararları, aşı uygulamalarındaki hukuki boşlukları tespit etmesi bakımından dikkate değerdir. Çalışmamızın konusunu oluşturan idarenin sorumluluğu ise hem zorunlu aşı hem de tavsiye edilen aşı uygulamalarında incelemeyi gerekmektedir. Danıştay’ın aşı zararından idarenin kusurlu sorumluluğunu esas alan istikrarlı yaklaşımı tartışmaya açıktır. Özellikle COVID-19 salgını ile tüm dünyada tartışılır hale gelmiş aşı çalışmaları ve her gün gelişen tıbbi tedavi yöntemleri sonrasında, idarenin sorumluluğunun boyutunun riskli/tehlikeli faaliyetler içerisinde değerlendirilmesi düşünülebilir. Ayrıca zorunlu veya tavsiye edilen aşıda, aşının çoğunlukla aşılanan kişi kadar topluma da koruma sağlaması zararın sosyal dayanışma ilkesi çerçevesinde kamu kaynaklarınan karşılanmasını haklı kılmaktadır. Bu makalede, zorunlu ve tavsiye edilen aşılar çerçevesinde idarenin sorumluluğuna dair tespitler yapılarak, öneriler sunulmaya çalışılacaktır.
İptal Edilebilirlik Yaptırımı: İslam Borçlar Hukuku Perspektifinden Bir İnceleme
Authors: Gökmen Emrah , Baş Seda
Published: June 2024

Hükümsüzlük, hukuk düzeni tarafından konulan kurallara eksik veya tam riayetsizlik hallerinde hukukun kişinin eylemlerine istediği sonucu bağlamaması olarak karşımıza çıkmaktadır. Hükümsüzlüğe ilişkin kategoriler hukuk düzenleri içerisinde ele alınmış ve zamanla bunlar geliştirilerek kapsamları genişletilmiştir. İslam borçlar hukukunda hükümsüzlük kategorileri genel olarak butlan, fesat, mevkûf ve gayr-i lâzım şeklindedir. Modern hükümsüzlük kategorilerinden biri olan iptal edilebilirlik, literatürde iptal teorisi ve geçersizlik teorisi olmak üzere iki açıdan ele alınmaktadır. İptal edilebilirlik yaptırımı, İslam borçlar hukukundaki hükümsüzlük kategorileri göz önünde bulundurularak daha önce müstakil bir çalışmaya konu edilmemiştir. Bu çalışmanın hareket noktası bu olup çalışmada iptal edilebilirliğin kapsam ve sınırları belirginleştirildikten sonra İslam borçlar hukukundaki hükümsüzlük kategorileri ana hatları ile sunulmuştur. Son bölümde çalışmanın ana ekseni olan söz konusu karşılaştırmaya ve buna ilişkin değerlendirmelere yer verilmiştir. Konunun somutlaştırılması adına irade bozukluğu halleri ve aşırı yararlanma özelinde değerlendirmeler yapılmıştır. Bu bağlamda, iptal teorisi ile gayr-i lâzımın, geçersizlik teorisi ile fesadın benzer düşüncelerle oluşturulmuş hukuki kurumlar olduğu düşünülmektedir. İslam borçlar hukukunda hata ve ikrah hallerinde fesat dolayısıyla geçersizlik teorisi, hile ve gabin hallerinde ise gayr-i lâzım dolayısıyla iptal teorisinin hâkim olduğu kanaatine varılmıştır.
Polimetilmetacrilato (PMMA) na prática clínica: Revisão integrativa sobre abordagens estéticas, complicações e aspectos regulatórios
Authors: Martins Elydiane Lopes , Kock Paula Alessandra , Fedatto Paola Fernanda
Published: June 2024

O uso do polimetilmetacrilato (PMMA) na prática clínica estética tem sido objeto de crescente interesse e debate, em virtude de sua aplicabilidade em procedimentos de rejuvenescimento facial e correção de defeitos ósseos. Reconhecido por sua durabilidade, biocompatibilidade e versatilidade, o PMMA é frequentemente utilizado para preenchimento facial e harmonização orofacial. No entanto, preocupações referentes a complicações e regulamentações também têm surgido. Nesse sentido, o objetivo deste estudo foi conduzir uma revisão integrativa da literatura a fim de analisar de forma abrangente as aplicações, complicações e aspectos regulatórios do PMMA na prática clínica estética. Para alcançar esse propósito, foram consultadas as bases de dados Google Acadêmico, LILACS e SciELO, abrangendo o período de 2018 a 2024. Ao longo da revisão, foram identificados diversos tipos de estudos, abrangendo revisões narrativas, revisões sistemáticas e estudos observacionais com descrição de casos. O PMMA mostrou-se amplamente empregado na esfera estética, em virtude de suas propriedades de biocompatibilidade, estabilidade mecânica e ausência de toxicidade, cor, sabor e odor. Este composto revelou ser utilizado em diversas áreas da medicina estética, tais como transplantes e próteses, oftalmologia, odontologia e correção estética de tecidos. Entretanto, também foram observadas complicações graves associadas a sua utilização, tais como embolia gordurosa, hipercalcemia, doença renal crônica e formação de granulomas e nódulos, resultando em edema, eritema, linfedemas e necrose tecidual. Ademais, preocupações regulatórias foram identificadas, incluindo a carência de padronização dos procedimentos e a ausência de diretrizes claras para o uso do PMMA na prática clínica no âmbito da estética.
Influência da dieta na saúde mental e desempenho cognitivo – uma revisão da literatura
Authors: Araújo Pedro Henrique Gadelha de , Duarte Arthur Oliveira , Silva Maria Cláudia da
Published: June 2024

A compreensão da relação entre escolhas alimentares e saúde mental tem ganhado destaque em um contexto global marcado por desafios crescentes como estresse, ansiedade e depressão. Este trabalho investigou essa conexão, examinando como a alimentação impacta não apenas a saúde física, mas também a saúde mental. Dessa forma o objetivo deste trabalho foi demonstrar a relação entre a alimentação e a saúde mental, enfocando o papel dos nutrientes na promoção do bem-estar psicológico e no aprimoramento do desempenho cognitivo. Este estudo é uma revisão da literatura, e buscou sintetizar e analisar pesquisas anteriores sobre a influência da dieta na saúde mental e no desempenho cognitivo. A abordagem é exploratória e visa consolidar evidências para enriquecer a compreensão do tema. A metologia adotada consiste em uma revisão sistemática da literatura, com uma análise abrangente de estudos publicados em bases de dados científicos como SCIELO, PUBMED e SCIENCE DIRECT. A pesquisa priorizou artigos científicos, revisões sistemáticas e meta-análises que abordam a relação entre dieta, estilo de vida, saúde mental e desempenho cognitivo. A análise crítica desses estudos contribui para o alcance dos objetivos propostos, fornecendo uma visão abrangente e atualizada da área. Os estudos, de maneira geral, demonstram que dietas ricas em gorduras saturadas e açúcar podem prejudicar o desempenho cerebral, alterando o funcionamento do hipocampo e comprometendo funções como memória e aprendizado. Ademais, mostra como a alimentação adequada tem ligação direta com a prevenção de transtornos de saúde mental e com o funcionamento cerebral.
In silico analysis of the protein-protein interaction of the SARS-CoV-2 spike protein
Authors: Marques Andressa Souza , Gondim Taiane de Macêdo , Sousa Fulvia Soares Campos de , Farias Antônio Pedro Fróes de , Andrade Bruno Silva , Trindade Soraya Castro , Rocha Filho José Tadeu Raynal da , Meyer Roberto
Published: June 2024

The pandemic caused by the SARS-CoV-2 virus has represented a global challenge with a significant impact on public health since its emergence in 2019. Understanding the interactions between this virus and the human immune system is essential for the development of new strategies more effective therapies and diagnoses. This study aimed to predict epitopes for SARS-CoV-2 T and B cells, as well as evaluate the interaction of the spike protein with other viral proteins, using bioinformatics methods. SARS-CoV-2 protein sequences were collected from UniProt. Epitopes for T cells were predicted in silico using specific HLA alleles from the Bahia population. Epitopes for B cells were predicted using the IEDB server with multiple methods based on amino acid features. Protein-protein interaction was analyzed using the STRING database. The result is 10,671 peptides related to various SARS-CoV-2 viral proteins, including the spike, essential for the infection and pathogenesis of COVID-19. In addition to spike, proteins such as ORF3a, ORF7a, and ORF8 showed significant immunogenic potential. Protein-protein interaction analysis revealed that proteases such as TMPRSS2 and TMPRSS11D are crucial for viral entry and are potential therapeutic targets. This study expands the understanding of the molecular interactions of SARS-CoV-2, highlighting new therapeutic targets and clinical complications associated with COVID-19. The results provide valuable insights for the development of targeted therapeutic strategies and improved diagnostics, contributing to the mitigation of the global pandemic.
A evolução da farmácia comunitária e a importância dos serviços farmacêuticos na atualidade
Authors: Costa Pedro Lucas Aguiar da , Lima Cristiane Gomes
Published: June 2024

O objetivo deste artigo consiste em destacar as principais funções do farmacêutico nas farmácias comunitárias e as barreiras encontradas para a execução das atividades necessárias para a dispensação de medicamentos de maneira segura e eficaz. O presente estudo seguiu a metodologia de Revisão de Literatura, do tipo integrativa e com abordagem qualitativa, foram utilizadas as bases de dados: Scielo, Lilacs e Medline. A evolução da farmácia comunitária se deu com relação a como passou a ser vista, nos dias atuais esse estabelecimento passou a ser de grande importância aliado as ações do farmacêutico para dispensar medicamentos de maneira segura e eficaz, reduzindo os índices de automedicação e melhorando cada vez mais a informação da população sobre sua doença e seu tratamento farmacológico. Mas para isso, o farmacêutico precisa ter conhecimentos específicos para sempre melhorar a segurança das orientações individuais realizadas na farmácia comunitária e assim contribuirá com a melhora na qualidade de vida do paciente.
As africanidades através das produções culturais Afro-diaspóricas Norte-Americanas e Brasileiras e seus Multiletramentos: Uma proposta de Sequência Didática para o Ensino de Língua Inglesa
Authors: Sousa Clauber Nascimento de , Ferreira Neto José Olímpio
Published: June 2024

O presente artigo tem o objetivo geral de apresentar uma proposta de Sequência Didática (SD) de Ensino de Língua Inglesa que destaque as africanidades através das produções culturais afro-diaspóricas norte-americanas e brasileiras. Apesar do ensino de Língua Inglesa ser obrigatório, conforme legislação, no Brasil, ainda continua sendo um privilégio. Trazer essa discussão é abrir um diálogo de como o ensino de línguas estrangeiras modernas pode contribuir para maior inclusão de populações minorizadas, pertencentes a comunidades desfavorecidas socialmente. Assim, aponta-se para uma maior versatilidade, contextualizada com a realidade dos estudantes, para promover uma aprendizagem mais significativa para a população negra, que pode ser atravessada por outros marcadores sociais, tais como gênero, sexualidade ou classe. A relevância deste trabalho mora na possibilidade de promoção da acessibilidade da Língua Inglesa, garantindo justiça social. A experiência apresentada foi aplicada numa escola pública da rede municipal de ensino de Fortaleza por meio de uma SD, relacionando a Língua Inglesa com outras manifestações culturais como: hip-hop, capoeira, samba de roda etc. Como resultados, foi possível perceber uma abertura de diálogo sobre o ensino de línguas estrangeiras modernas e sua relação com as produções étnicas minorizadas nos EUA e no Brasil. Também foi possível perceber que a SD contribui para o aprendizado da Língua Inglesa em comunidades desfavorecidas socialmente.
Eksistensi Penerapan Keadilan Restoratif Melalui Mediasi Penal Perspektif Maslahah Mursalah di Indonesia
Authors: Ahmad Wildan Rofrofil Akmal
Published: June 2024

Implementasi mediasi penal mulai dari kepolisian hingga pengadilan harus didukung oleh regulasi hukum yang jelas untuk memastikan bahwa konsep keadilan restoratif dapat terwujud dengan baik. Prinsip keadilan restoratif menekankan pentingnya peradilan dalam mempertajam analisis hukum dan memperkuat naluri keadilan berdasarkan pada kesadaran umat manusia dan nilai-nilai moral. Tujuan penelitian ini untuk mengetahui eksistensi penerapan keadilan restoratif melalui mediasi penal perspektif maslahah mursalah hajjiyah di Indonesia. Penelitian ini menggunakan penelitian yuridis normatif, menggunakan pendekatan peraturan perundang-undangan dan konseptual. Hasil penelitian didapatkan adanya mediasi penal ini sesuai dengan konsep pemenuhan maslahah mursalah hajjiyah yang mana semua bentuk perbuatan dan tindakan yang tidak terkait dengan dasar yang lain yang dibutuhkan oleh masyarakat, mediasi penal ini sesuai dengan konsep pemenuhan maslahah mursalah hajjiyah.
Legitimasi Hukum Asing Sebagai Pertimbangan Putusan oleh Mahkamah Konstitusi: Perbandingan Antara Indonesia dan Afrika Selatan
Authors: Zuhdi Achmad , Kamula Ari Ade
Published: June 2024

Isu merujuk pada hukum asing dalam pertimbangan konstitusional sering memicu kritik sebagai “cherry picking”. Penelitian ini mengkaji bagaimana Mahkamah Konstitusi Indonesia dan Afrika Selatan menggunakan hukum asing dalam yurisprudensi mereka, dengan fokus pada legitimasi dan dampaknya terhadap perlindungan hak asasi manusia dan prinsip-prinsip demokrasi. Penelitian ini menggunakan metode yuridis normatif dengan pendekatan komparatif, perundang-undangan, dan historis dengan menganalisis putusan-putusan dari kedua pengadilan serta sumber-sumber sekunder yang relevan. Temuan menunjukkan bahwa kedua pengadilan tersebut menggunakan hukum asing tetapi berbeda secara signifikan dalam pendekatannya. Mahkamah Konstitusi Afrika Selatan sering mengutip preseden asing secara langsung, sementara Mahkamah Konstitusi Indonesia lebih sering menggunakan hukum internasional sebagai referensi. Penelitian ini menyimpulkan bahwa penggunaan hukum asing oleh Mahkamah Konstitusi dapat meningkatkan yurisprudensi hak asasi manusia dan demokrasi jika diintegrasikan dengan baik ke dalam kerangka hukum nasional.
Crystal Structure and Hirshfeld Surface Analysis of a Heterometallic Hofmann-Type-Like Compound
Authors: Kartal Zeki , Şahin Zarife Sibel
Published: June 2024

In this study; a new heterometallic compound defined by the open formula [Cd(H2O)2Ni(CN)4]4[Cd(H2O)4Ni(CN)4]5 was synthesized in crystal form. Consisting of components such as water molecules, [Ni(CN)4]2− anions, and cadmium transition metal atoms, this new crystal structure has no analogues which might have been previously obtained, even with other transition metal atoms. It is a new compound and a unique example of a crystal. The structural properties of this heterometallic compound have been characterized by single crystal X-ray diffraction spectroscopy (SC-XRD), FT-IR spectroscopy, thermal analysis and elemental analysis methods. According to the data obtained from the SC-XRD technique, this heterometallic compound has a monoclinic crystal system and a C2/c space group. The asymmetric unit of this compound consists of five Cd(II) ions, five Ni(II) ions, eighteen cyanide ligands, and fourteen coordinated water ligand molecules. In addition, theoretical calculations have been made with the Gaussian 03 program in order to obtain more information about this heterometallic Hofmann-type-like compound. The chemical properties of this new compound have been calculated using its HOMO and LUMO values and the natural bond orbital (NBO) analyses. In addition, Hirshfeld surface analysis of the asymmetric unit of this compound has been performed with the CrystalExplorer program. As a result of the Hirshfeld surface analysis, extensive information has been obtained about the weak intramolecular and intermolecular forces that form this new crystalline compound.
UBE2S promotes glycolysis in hepatocellular carcinoma by enhancing E3 enzyme-independent polyubiquitination of VHL
Authors: Zhang Renyu , Li Can , Zhang Shuai , Kong Lingmin , Liu Zekun , Guo Yixiao , Sun Ying , Zhang Cong , Yong Yule , Lv Jianjun , Lu Meng , Liu Man , Wu Dong , Zhang Tianjiao , Yang Haijiao , Wei Ding , Chen Zhinan , Bian Huijie
Published: June 2024

Background/Aims: Ubiquitination is widely involved in the progression of hepatocellular carcinoma (HCC) by regulating various cellular processes. However, systematic strategies for screening core ubiquitin-related genes, clarifying their functions and mechanisms, and ultimately developing potential therapeutics for patients with HCC are still lacking.Methods: Cox and LASSO regression analyses were performed to construct a ubiquitin-related gene prediction model for HCC. Loss- and gain-of-function studies, transcriptomic and metabolomics analysis were used to explore the function and mechanism of UBE2S on HCC cell glycolysis and growth.Results: Based on 1,423 ubiquitin-related genes, a four-gene signature was successfully constructed to evaluate the prognosis of patients with HCC. UBE2S was identified in this signature with the potential to predict the survival of patients with HCC. E2F2 transcriptionally upregulated UBE2S expression by directly binding to its promoter. UBE2S positively regulated glycolysis in a HIF-1α-dependent manner, thus promoting the proliferation of HCC cells. Mechanistically, UBE2S enhanced K11-linkage polyubiquitination at lysine residues 171 and 196 of VHL independent of E3 ligase, thereby indirectly stabilizing HIF-1α protein levels by mediating the degradation of VHL by the proteasome. In particular, the combination of cephalomannine, a small molecule compound that inhibits the expression of UBE2S, and PX-478, an inhibitor of HIF-1α, significantly improved the anti-tumor efficacy.Conclusions: UBE2S is identified as a key biomarker in HCC among the thousands of ubiquitin-related genes and promotes glycolysis by E3 enzyme-independent ubiquitination, thus serving as a therapeutic target for the treatment of HCC.
Circadian Disruption in Civilian Airline Pilots
Authors: Yang Sophie Xin , Cheng Siyu , Sun Yuanfeng , Tang Xiangdong , Huang Zhijiao
Published: June 2024

INTRODUCTION: Most airline pilots reported having suffered from sleep disorders and fatigue due to circadian disruption, a potential risk to flight safety. This study attempted to uncover the actual scenario of circadian disruption and working load status among airline pilots.

METHODS: In study 1, 21 pilots were invited to participate in a 14-d sleep monitoring and a dual 2-back test to monitor their sleep patterns and cognitive function level. To provide an in-depth view, data from scheduled flights, including 567 airline pilots, was analyzed in Study 2. The present study used cluster analysis to reflect the distribution of the flight scheduling characteristics, including working time and actual working hours. A simulation model was then developed to predict the pilots’ 1-mo sleep-wake pattern.

RESULTS: The results indicated that sleep problems were prevalent in this population, especially the night before an earlier morning shift. Regarding the cognitive test, they scored the lowest on earlier morning shifts compared with daytime and evening shifts. It was found that over 70% of the flight schedules can lead to circadian disruption, and 47.44% of the pilots worked under high-load status.

DISCUSSION: Airline pilots inevitably work irregular hours and the current policies for coping with circadian disruption seem inefficient. This study thus calls for urgency in improving scheduling and fatigue management systems from the circadian rhythm perspective.

Yang SX, Cheng S, Sun Y, Tang X, Huang Z. Circadian disruption in civilian airline pilots. Aerosp Med Hum Perform. 2024; 95(7):381–389.
Expiratory Threshold Loading and Attentional Performance
Authors: Kelley Eli F. , Cross Troy J. , Johnson Bruce D.
Published: June 2024

INTRODUCTION: While there are numerous factors that may affect pilot attentional performance, we hypothesize that an increased expiratory work of breathing experienced by fighter pilots may impose a “distraction stimulus” by creating an increased expiratory effort sensation. Therefore, the purpose of this study was to determine the extent to which increasing expiratory pressure time product or expiratory effort sensation impacts attentional performance.

METHODS: Data was collected on 10 healthy participants (age: 29 ± 6 yr). Participants completed six repetitions of a modified Masked Conjunctive Continuous Performance Task protocol while breathing against four different expiratory threshold loads. Repeated measures analysis of variances and generalized additive mixed effects models were used to investigate the effects of expiratory threshold load conditions on expiratory pressure time product, expiratory effort sensation, and the influence of altered end tidal gases on Masked Conjunctive Continuous Performance Task scores.

RESULTS: The overall median hit reaction times were significantly longer as the expiratory threshold loads increased. Specific shape-conjunctive and non-conjunctive median hit reaction times were longer with increased expiratory effort sensation. Additionally, increased expiratory effort sensation did not significantly change commission error rates, but did significantly increase omission error rates.

DISCUSSION: The findings of our work suggest that both progressively greater expiratory threshold loads during spontaneous breathing and expiratory effort sensation may impair subjects’ attentional performance due to longer reaction times and increased stimuli recognition error rates.

Kelley EF, Cross TJ, Johnson BD. Expiratory threshold loading and attentional performance. Aerosp Med Hum Perform. 2024; 95(7):367–374.
Relative Severity of Human Performance Decrements Recorded in Rapid vs. Gradual Decompression
Authors: Beer Jeremy , Mojica Andrew J. , Blacker Kara J. , Dart Todd S. , Morse Bria G. , Sherman Paul M.
Published: June 2024

INTRODUCTION: Cabin decompression presents a threat in high-altitude-capable aircraft. A chamber study was performed to compare effects of rapid (RD) vs. gradual decompression and gauge impairment at altitude with and without hypoxia, as well as to assess recovery.

METHODS: There were 12 participants who completed RD (1 s) and Gradual (3 min 12 s) ascents from 2743–7620 m (9000–25000 ft) altitude pressures while breathing air or 100% O2. Physiological indices included oxygen saturation (SPo2), heart rate (HR), respiration, end tidal O2 and CO2 partial pressures, and electroencephalography (EEG). Cognition was evaluated using SYNWIN, which combines memory, arithmetic, visual, and auditory tasks. The study incorporated ascent rate (RD, gradual), breathing gas (air, 100% O2) and epoch (ground-level, pre-breathe, ascent-altitude, recovery) as factors.

RESULTS: Physiological effects in hypoxic “air” ascents included decreased SPo2 and end tidal O2 and CO2 partial pressures (hypocapnia), with elevated HR and minute ventilation (E); SPo2 and HR effects were greater after RD (−7.3% lower and +10.0 bpm higher, respectively). HR and E decreased during recovery. SYNWIN performance declined during ascent in air, with key metrics, including composite score, falling further (−75% vs. −50%) after RD. Broad cognitive impairment was not recorded on 100% O2, nor in recovery. EEG signals showed increased slow-wave activity during hypoxia.

DISCUSSION: In hypoxic exposures, RD impaired performance more than gradual ascent. Hypobaria did not comprehensively impair performance without hypoxia. Lingering impairment was not observed during recovery, but HR and E metrics suggested compensatory slowing following altitude stress. Participants’ cognitive strategy shifted as hypoxia progressed, with efficiency giving way to “satisficing,” redistributing effort to easier tasks.

Beer J, Mojica AJ, Blacker KJ, Dart TS, Morse BG, Sherman PM. Relative severity of human performance decrements recorded in rapid vs. gradual decompression. Aerosp Med Hum Perform. 2024; 95(7):353–366.
Waiting with Beckett in the Anthropocene
Authors: Salisbury Laura
Published: June 2024

This article asks what we might make of Samuel Beckett’s persistent aesthetic and ethical commitment to waiting during a moment shot through with calls to action in the face of extinction events and climate catastrophe. Concentrating on Beckett’s ‘grey time’ and interest in Freud’s death drive, I argue that Beckett’s work uses the temporal suspension of the ‘meanwhile’ to attend to how bodies and selves endure through time when there has been a withdrawal of care for the version of the human that has imagined itself able to produce and mark the end of multiple human and more-than-human others. Beckett’s scenes of endless ending, as forms of what Leo Bersani might call ‘willed lessness’, carefully return us to the ongoing relationship within and between human and more-than-human worlds, sustained according to different configurations of intensity. In the place of action, what persists in the ‘meanwhile’ is a drive that ‘de-dramatizes’ the human as a ‘subject of knowledge’, so that things might die in their own time and after their own fashion.
Attunement Space and Eco-Deconstruction in Malone Dies
Authors: Tsushima Michiko
Published: June 2024

As exemplified by Timothy Morton’s argument, what is at stake in the discussion of the Anthropocene is the need to deconstruct the closedness of the anthropocentric world and recover the fundamental connection between the human and the nonhuman that has been suppressed by it. This essay attempts to examine how Malone Dies shows the possibility of eco-deconstruction, not in the sense of an idealistic or normative ethics of ecology, but rather in presenting us a uniquely imaginative ‘attunement space’ that allows for an alternative form of sensitivity to the profound and paradoxical intimacy between the human and the nonhuman. Beckett's vision in Malone Dies resonates with Morton's vision of ecological being, but takes it to a more enigmatic place that more fully takes into account both the violence and the receptivity within the ‘grey zone’ between human and nonhuman. In Beckett's view, it is necessary to descend to a limit (non-)place like the ‘attunement space’ presented in this novel, where ordinary sensory perception and temporal and spatial restrictions dissolve. The essay shows how this ‘attunement space’ unveils itself in several overlapping layers. First, there is the layer of something articulated in terms of the spiritual, a realm of what Malone calls ‘the soul’. Then there is another layer that involves the perception of the unperceivable, which is usually hindered by ordinary human sensory perception. In this realm something fundamental that exists prior to all phenomena and things is revealed – something that is inseparable from what Beckett calls the ‘buzzing confusion’, ‘the mess’, or ‘the chaos’. This unique perception takes place in the realms of both sight and sound. The attunement to an undifferentiated dimension in Malone Dies makes possible an ecological awareness of the already existing intimacy with nonhuman life, as Morton describes.
Review of Strategies and Policies for Participation in Global Value Chains
Authors: Dutta Sourish
Published: June 2024

This article reiterates the importance of understanding and addressing the strategic inquiries and potential responses in the context of global value chain (GVC) participation. Policymakers must address these crucial matters to engage in GVCs effectively. Governments aspiring to participate in GVCs must focus on determining which tasks to prioritise and exploring various forms of GVC governance. The challenges and opportunities of establishing top-notch GVC connections and fostering a favourable environment for foreign assets are significant for countries looking to integrate into GVCs. However, the potential benefits of GVC participation are vast. Significant economic growth and development can be achieved by attracting suitable foreign investors, enhancing market connectivity, and developing high-quality infrastructure and services. By understanding and addressing the strategic inquiries and possible responses, policymakers can take control of the situation and pave the way for a prosperous future.
Perancangan aplikasi multi layanan berbasis super app
Authors: Hardiyanto Muhammad Fernanda , Andarwati Mardiana
Published: June 2024

Proses manual mengacu pada pekerjaan yang dilakukan oleh manusia, seperti mengisi formulir secara manual. Sedangkan proses otomatisasi mengacu pada pekerjaan yang dilakukan oleh mesin atau perangkat lunak, seperti program pembayaran semester genap dan ganjil. Tujuan penelitian ini adalah Mendalami dan menganalisis kebutuhan pengguna dalam sebuah aplikasi multi layanan guna menciptakan pengalaman pengguna yang terfokus dan memenuhi kebutuhan individu serta kelompok pengguna secara efektif. Mengidentifikasi, mengevaluasi, dan mengintegrasikan fitur-fitur yang diperlukan dalam rangka menciptakan pengalaman pengguna yang terintegrasi dan komprehensif pada berbagai platform aplikasi. Merancang antarmuka pengguna yang intuitif dengan fokus pada penyediaan akses dan navigasi yang mudah dalam aplikasi. Metode yang digunakan yaitu metode Rapid Application Development (RAD). Metode RAD menggunakan metode berulang dalam pengembangan sistem. Aplikasi memberikan kemudahan pengguna dalam mengirim saldo ke rekening bank dengan fleksibilitas nominal, tanpa memerlukan kunjungan ke ATM atau bank. Fitur utama aplikasi memastikan transaksi finansial diselesaikan dengan cepat dan efisien, meningkatkan kenyamanan pengguna dalam menjalankan operasional keuangan mereka
ABSTRACTManual processes refer to work performed by humans, such as manually filling out forms. On the other hand, automation processes refer to work performed by machines or software, such as semester tuition payment programs. The objective of this research is to delve into and analyze user needs within a multi-service application to create a user experience that is focused and effectively meets the needs of individual users and user groups. This includes identifying, evaluating, and integrating necessary features to create an integrated and comprehensive user experience across various application platforms. The research also involves designing an intuitive user interface with a focus on providing easy access and navigation within the application. The method used is Rapid Application Development (RAD). RAD methodology employs iterative methods in system development. The outcome of this research is an application that provides users with convenience in transferring balances to bank accounts with flexible amounts, without requiring visits to ATMs or banks. The application's key features ensure that financial transactions are completed quickly and efficiently, enhancing user comfort in managing their financial operations.