bluuebunny/crossref_metadata_2025 huggingface dataset:
Nanoliposome Use to Improve the Stability of Phenylethyl Resorcinol and Serve as a Skin Penetration Enhancer for Skin Whitening
Authors: Xia Huan , Tang Yan , Huang Rufei , Liang Jinlian , Ma Siying , Chen Derong , Feng Yuqing , Lei Yaling , Zhang Qi , Yang Yan , Huang Yadong
Published: March 2022

Phenylethyl resorcinol (PR) is a potent tyrosinase inhibitor and a cosmeceutical skin lightening agent. However, the application of PR is limited by photoinstability and poor solubility. In this study, we formulated and optimized phenylethyl resorcinol loaded nanoliposomes (PR-NLPs) to improve the stability and effective delivery of PR. PR-NLPs were prepared by the ethanol injection method and optimized by a single factor experimental and Box–Behnken design. In addition, Diethylamino Hydroxybenzoyl Hexyl Benzoate (DHHB) as the UBA absorber was added to PR-NLPs, which significantly improved the photostability of PR. The mean size, polydispersity index (PDI), and zeta potential of the optimized PR-NLPs were 130.1 ± 3.54 nm, 0.225 ± 0.02, and −43.9 ± 3.44 mV, respectively. The drug encapsulation efficiency (EE) and loading efficiency (LC) of PR-NLPs were 96.81 ± 3.46% and 8.82 ± 0.6%, respectively. These PR-NLPs showed good physicochemical stability for 3 months at 4 °C and 25 °C in the dark. They showed typical sustained and prolonged drug-release behavior in vitro. The in vitro cytotoxicity assay and cellular uptake demonstrated that the PR-NLPs had excellent biocompatibility and cell transport ability. It significantly inhibited tyrosinase activity and reduced melanin production in B16F10 cells at concentrations of 20 or 30 μg/mL. Moreover, the PR-NLPs enhanced the PR into the skin. These results indicate that PR-NLPs can be used as a nanocarrier to improve the transdermal delivery of PR.
Microscopy-Assisted Digital Image Analysis with Trainable Weka Segmentation (TWS) for Emulsion Droplet Size Determination
Authors: Salum Pelin , Güven Onur , Aydemir Levent Yurdaer , Erbay Zafer
Published: March 2022

The size distribution of droplets in emulsions is very important for adjusting the effects of many indices on their quality. In addition to other methods for the determination of the size distribution of droplets, the usage of machine learning during microscopic analyses can enhance the reliability of the measurements and decrease the measurement cost at the same time. Considering its role in emulsion characteristics, in this study, the droplet size distributions of emulsions prepared with different oil/water phase ratios and homogenization times were measured with both a microscopy-assisted digital image analysis technique and a well-known laser diffraction method. The relationships between the droplet size and the physical properties of emulsions (turbidity and viscosity) were also investigated. The results showed that microscopic measurements yielded slightly higher values for the D(90), D[3,2], and D[4,3] of emulsions compared to the laser diffraction method for all oil/water phase ratios. When using this method, the droplet size had a meaningful correlation with the turbidity and viscosity values of emulsions at different oil/water phase ratios. From this point of view, the usage of the optical microscopy method with machine learning can be useful for the determination of the size distribution in emulsions.
Ti/SnO2-Sb2Ox-TiO2 Electrodeposited from Methanesulfonate Electrolytes: Preparation, Properties, and Performance
Authors: Zhang Shengping , Yu Chen , Tan Jingyi , Wang Yuxin , He Zhen
Published: March 2022

In this study, Ti/SnO2-Sb2Ox-TiO2 electrodes were produced using a sol-enhanced electrodeposition technique from methanesulfonate electrolytes. The surface microstructures of Ti/SnO2-Sb2Ox-TiO2 were observed, and their phase constituents were determined. The surface features were analyzed by X-ray photoelectron spectroscopy. Linear sweep voltammetry and degradation tests were also conducted to determine the degradation performance. The results show that the addition of TiO2 sol affects the microstructures of Ti/SnO2-Sb2Ox-TiO2 electrodes, while a uniform coating surface can be obtained at a proper sol concentration in electrolytes. Adding TiO2 sol also causes deep oxidation of Sb and generates more adsorbed oxygen on the electrode surface. The favorable surface features and the well-dispersed TiO2 in the coatings of 10 mL/L TiO2 modified Ti/SnO2-Sb2Ox-TiO2 electrodes award them the best electrocatalytic performance, and their uniform coating surface prolongs the electrode service life.
Photosensitive Alignment: Advanced Electronic Paper-Based Devices
Authors: Chigrinov Vladimir , Kudreyko Aleksey , Sun Jiatong
Published: March 2022

In this review we describe the reversible photoalignment effect imposed on the director in nematic liquid crystals that provides an approach for fabrication of advanced optically addressed devices. Several new concepts have been developed to render photosensitive materials during the past decade. Functional soft azo dye compounds exhibiting distinct functionalities in response to polarized light are highly desirable for fabrication of optically rewritable electronic paper. An optically rewritable element base using simple and inexpensive materials can potentially enable the development of novel environmentally friendly, paper-like gadgets with improved functionality over regular electronic paper. We argue that an optically rewritable technique is relevant for some applications, where conventional paper might be irrelevant. In particular, we have tested and discussed several techniques of color and 3D image formation. This strategy for fabrication of novel devices offers versatile methods for visualization. We also show that the intensity modulation of the irradiation light has a potential to generate improved grayscale visualization. This principle is based on the statistical distribution control of photosensitive azo dye molecules, driven by the incident polarized light. Additionally, we discuss the functional characteristics of the developed prototypes.
Effect of Nano-Si3N4 Reinforcement on the Microstructure and Mechanical Properties of Laser-Powder-Bed-Fusioned AlSi10Mg Composites
Authors: Lu Zhongliang , Han Yu , Gao Yunpeng , Cao Fusheng , Zhang Haitian , Miao Kai , Deng Xin , Li Dichen
Published: March 2022

Laser powder bed fusion (LPBF) technology is of great significance to the rapid manufacturing of high-performance metal parts. To improve the mechanical behavior of an LPBFed AlSi10Mg alloy, the influence of nano-Si3N4 reinforcement on densification behavior, microstructure, and tensile property of AlSi10Mg was studied. The experimental results show that 97% relative density of the 3 vol.% nano-Si3N4/AlSi10Mg composite was achieved via optimization of the LPBF process. With the increase in the nano-Si3N4 content, the tensile strength and the yield strength of the composite steadily increase as per the Orowan strengthening mechanism while the elongation decreases. In addition, nano-Si3N4 reinforcement reduces the width of the coarse cell structure region and the thermal influence region of the AlSi10Mg matrix. After annealing, the tensile strength of the nano-Si3N4/AlSi10Mg composite decreases and the elongation increases significantly.
Diencephalic Syndrome Due to Optic Pathway Gliomas in Pediatric Patients: An Italian Multicenter Study
Authors: De Martino Lucia , Picariello Stefania , Triarico Silvia , Improda Nicola , Spennato Pietro , Capozza Michele Antonio , Grandone Anna , Santoro Claudia , Cioffi Daniela , Attinà Giorgio , Cinalli Giuseppe , Ruggiero Antonio , Quaglietta Lucia
Published: March 2022

Diencephalic syndrome (DS) is a rare pediatric condition associated with optic pathway gliomas (OPGs). Since they are slow-growing tumors, their diagnosis might be delayed, with consequences on long-term outcomes. We present a multicenter case series of nine children with DS associated with OPG, with the aim of providing relevant details about mortality and long-term sequelae. We retrospectively identified nine children (6 M) with DS (median age 14 months, range 3–26 months). Four patients had NF1-related OPGs. Children with NF1 were significantly older than sporadic cases (median (range) age in months: 21.2 (14–26) versus 10 (3–17); p = 0.015). Seven tumors were histologically confirmed as low-grade astrocytomas. All patients received upfront chemotherapy and nutritional support. Although no patient died, all of them experienced tumor progression within 5.67 years since diagnosis and were treated with several lines of chemotherapy and/or surgery. Long-term sequelae included visual, pituitary and neurological dysfunction. Despite an excellent overall survival, PFS rates are poor in OPGs with DS. These patients invariably present visual, neurological or endocrine sequelae. Therefore, functional outcomes and quality-of-life measures should be considered in prospective trials involving patients with OPGs, aiming to identify “high-risk” patients and to better individualize treatment.
The Impact of Age on In-Hospital Mortality in Critically Ill COVID-19 Patients: A Retrospective and Multicenter Study
Authors: Le Borgne Pierrick , Dellenbach Quentin , Alame Karine , Noizet Marc , Gottwalles Yannick , Chouihed Tahar , Abensur Vuillaume Laure , Lavoignet Charles-Eric , Bérard Lise , Molter Lise , Gennai Stéphane , Kepka Sabrina , Lefebvre François , Bilbault Pascal
Published: March 2022

Introduction: For the past two years, healthcare systems worldwide have been battling the ongoing COVID-19 pandemic. Several studies tried to find predictive factors of mortality in COVID-19 patients. We aimed to research age as a predictive factor associated with in-hospital mortality in severe and critical SARS-CoV-2 infection. Methods: Between 1 March and 20 April 2020, we conducted a multicenter and retrospective study on a cohort of severe COVID-19 patients who were all hospitalized in the Intensive Care Unit (ICU). We led our study in nine hospitals of northeast France, one of the pandemic’s epicenters in Europe. Results: The median age of our study population was 66 years (58–72 years). Mortality was 24.6% (CI 95%: 20.6–29%) in the ICU and 26.5% (CI 95%: 22.3–31%) in the hospital. Non-survivors were significantly older (69 versus 64 years, p < 0.001) than the survivors. Although a history of cardio-vascular diseases was more frequent in the non-survivor group (p = 0.015), other underlying conditions and prior level of autonomy did not differ between the two groups. On multivariable analysis, age appeared to be an interesting predictive factor of in-hospital mortality. Thus, age ranges of 65 to 74 years (OR = 2.962, CI 95%: 1.231–7.132, p = 0.015) were predictive of mortality, whereas the group of patients aged over 75 years was not (OR = 3.084, CI 95%: 0.952–9.992, p = 0.06). Similarly, all comorbidities except for immunodeficiency (OR = 4.207, CI 95%: 1.006–17.586, p = 0.049) were not predictive of mortality. Finally, survival follow-up was obtained for the study population. Conclusion: Age appears to be a relevant predictive factor of in-hospital mortality in cases of severe or critical SARS-CoV-2 infection.
The Importance of Cardiac Computed Tomography in the Diagnosis of Caseous Calcification of the Mitral Annulus—Case Reports
Authors: Gać Paweł , Cheładze Przemysław , Poręba Rafał
Published: March 2022

Mitral annular calcification (MAC) is a common pathology of the mitral valve. In rare cases, calcifications occur in the mitral annulus degenerate serous; the caseous calcification of the mitral annulus (CCMA) then develops. Detection of CCMA is often random and requires differentiation from heart tumors or an abscess. The paper presents two cases of patients with ambiguous focal lesions of the mitral valve in echocardiography. In the first case, the cardiac computed tomography (CCT) showed a spherical, slightly irregular structure measuring approximately 33 × 22 mm, which was in contact with the posterior mitral valve leaflet from the lumen of the left ventricle. The lesion was heterogeneously intense, with an average density of about 500 HU and up to 975 HU on the periphery; it was not enhanced after the administration of a contrast agent. In the second case, the CCT revealed a heterogeneous, highly calcified structure in the peripheral zone and intermediate density in the central zone in the topography of the posterior mitral valve leaf, with dimensions up to about 41 × 31 mm in the plane of the valve leaflet, passing into the lumen of the left ventricle along its inferolateral wall to a depth of about 3.5 cm. In both cases, CCT enabled the diagnosis of CCMA. In conclusion, cardiac computed tomography may be decisive in the case of suspected caseous calcification of the mitral annulus where there is ambiguous echocardiography.
Deal Me in: Playing Cards in the Home to Learn Math
Authors: Scalise Nicole R. , DePascale Mary , Tavassolie Nadia , McCown Claire , Ramani Geetha B.
Published: March 2022

Recent meta-analyses have demonstrated a significant association between children’s early math achievement and their experiences with math at home, including their caregivers’ talk about math. However, few studies have investigated the relations between caregiver math talk and children’s learning with experimental designs. Eighty-six children (M = 5.0 years) and their caregivers were randomly assigned to play either a numeracy or a shape card game at home for six weeks. Data were collected on children’s number and shape knowledge and families’ math talk during gameplay. There was substantial participant attrition (42% did not return completed materials), however, both an intent-to-treat analysis of the sample that received study materials and a subgroup analysis of study completers showed that children who played the shape game significantly improved their shape naming and matching skills relative to children who played the number game. Children who played the number game did not significantly improve their numerical skills relative to children who played the shape game. Mathematical talk during gameplay varied between families but was correlated over time within families. Caregivers’ and children’s talk about matching cards by shape or color predicted children’s learning from the shape game. The results suggest that despite receiving uniform instructions and materials, there was significant variability in children’s home math experiences that predicted their learning from the card game.
Enablers and Difficulties in the Implementation of Gamification: A Case Study with Teachers
Authors: Araújo Inês , Carvalho Ana Amélia
Published: March 2022

Although there is ample evidence that gamification can engage students in learning, it is less used than one would expect. This raises the question of the difficulties teachers face in planning and implementing gamification in their classes. What enables teachers’ implementation of gamification? These questions were addressed through a case study, and data were collected along the four phases of a teachers’ training course. The first phase approached the gamification concept, the Octalysis Framework, the types of gamification, and digital tools. The second phase focused on planning the gamification activity, the third one on implementing it with their students in school, and the fourth phase on sharing and reflecting on their experience. It was possible to identify enablers and difficulties that influenced the planning, such as personal background, time available, and technical conditions in the classroom. Most teachers opted for a platform with digital tools that allowed them to apply all the desired features to their gamified activities. The most complex gamified activities were related to the teacher’s gaming experience, use of digital tools, and risk-taking.
Postwall-Slotline Stepped Impedance Resonator and Its Application to Bandpass Filter with Improved Upper Stopband
Authors: Yang Liang , Lu Cheng , Wang Jialin , Li Shunli , Zhao Hongxin , Yin Xiaoxing
Published: March 2022

In this letter, a postwall-slotline stepped impedance resonator (PWS-SIR) is proposed and applied to a bandpass filter (BPF) with a wide stopband. The proposed PWS-SIR-BPF comprises three U-shaped PWS-SIRs and two microstrip-slot feeding transitions. A PWS has a much lower impendence which a conventional slotline (CSL) cannot reach, so a much smaller impendence ratio of the PWS-SIR can be achieved. Consequently, a wider stopband simultaneously can be realized for the proposed filter. The designed PWS-SIR-BPF, as well as a CSL-BPF, have been fabricated, measured, and compared to verify the features of the PWS-SIR. The measured results are consistent with the simulation ones. The PWS-SIR is 7.3 mm (0.22λ0) long, 67% of 11.1 mm (0.34λ0) of the CSL resonator. The first spurious resonance frequency of the PWS-SIR-BPF is extended from 9.8 GHz (2f0) to 23 GHz (4.7f0).
Using Open Tools to Transform Retired Equipment into Powerful Engineering Education Instruments: A Smart Agri-IoT Control Example
Authors: Loukatos Dimitrios , Androulidakis Nikolaos , Arvanitis Konstantinos G. , Peppas Kostas P. , Chondrogiannis Eleftherios
Published: March 2022

People getting involved with modern agriculture should become familiar with and able to exploit the plethora of cutting-edge technologies that have recently appeared in this area. The contribution of the educational robotics in demystifying new scientific fields for K-12 students is remarkable, but things become more challenging when trying to discover efficient practices for higher education. Indeed, there is an apparent need for pilot examples facilitating students’ professional skills acquisition and thus matching the potential of the actual systems used in the modern agricultural premises. In this regard, this work discuses laboratory experiences while implementing an automatic airflow control system of convincing size and role capable for remote configuration and monitoring. This non-conventional robotic example exploits retired electromechanical equipment, from an old farm, and revives it using modern widely available microcontrollers, smart phones/tablets, network transceivers, motor drivers, and some cheap and/or custom sensors. The contribution of the corresponding software parts to this transformation is of crucial importance for the success of the whole system. Thankfully, these parts are implemented using easy-to-use programming tools, of open and free nature at most, that are suitable for the pairing credit-card-sized computer systems. The proposed solution is exhibiting modularity and scalability and assists students and future professionals to better understand the role of key elements participating in the digital transformation of the agricultural sector. The whole approach has been evaluated from both technical and educational perspective and delivered interesting results that are also reported.
Research on Secure Communication on In-Vehicle Ethernet Based on Post-Quantum Algorithm NTRUEncrypt
Authors: Zhu Yuan , Liu Yipeng , Wu Mingzhi , Li Jinzhao , Liu Shiyang , Zhao Jianning
Published: March 2022

In the context of the evolution of in-vehicle electronic and electrical architecture as well as the rapid development of quantum computers, post-quantum algorithms, such as NTRUEncrypt, are of great significance for in-vehicle secure communications. In this paper, we propose and evaluate, for the first time, a NTRUEncrypt enhanced session key negotiation for the in-vehicle Ethernet context. Specifically, the time consumption and memory occupation of the NTRUEncrypt Elliptic Curve Diffie–Hellman (ECDH), and Rivest–Shamir–Adleman (RSA) algorithms, which are used for session key negotiation, are measured and compared. The result shows that, besides the NTRUEncrypt’s particular attribute of resisting quantum computer attacks, the execution speed of session key negotiation using NTRUEncrypt is 66.06 times faster than ECDH, and 1530.98 times faster than RSA at the 128-bit security level. The memory occupation of the algorithms is at the same order of magnitude. As the transport layer security (TLS) protocol can fulfill most performance requirements of the automotive industry, post-quantum enhanced session key negotiation will probably be widely used for in-vehicle Ethernet communication.
MobileNets Can Be Lossily Compressed: Neural Network Compression for Embedded Accelerators
Authors: Lim Se-Min , Jun Sang-Woo
Published: March 2022

Although neural network quantization is an imperative technology for the computation and memory efficiency of embedded neural network accelerators, simple post-training quantization incurs unacceptable levels of accuracy degradation on some important models targeting embedded systems, such as MobileNets. While explicit quantization-aware training or re-training after quantization can often reclaim lost accuracy, this is not always possible or convenient. We present an alternative approach to compressing such difficult neural networks, using a novel variant of the ZFP lossy floating-point compression algorithm to compress both model weights and inter-layer activations and demonstrate that it can be efficiently implemented on an embedded FPGA platform. Our ZFP variant, which we call ZFPe, is designed for efficient implementation on embedded accelerators, such as FPGAs, requiring a fraction of chip resources per bandwidth compared to state-of-the-art lossy compression accelerators. ZFPe-compressing the MobileNet V2 model with an 8-bit budget per weight and activation results in significantly higher accuracy compared to 8-bit integer post-training quantization and shows no loss of accuracy, compared to an uncompressed model when given a 12-bit budget per floating-point value. To demonstrate the benefits of our approach, we implement an embedded neural network accelerator on a realistic embedded acceleration platform equipped with the low-power Lattice ECP5-85F FPGA and a 32 MB SDRAM chip. Each ZFPe module consumes less than 6% of LUTs while compressing or decompressing one value per cycle, requiring a fraction of the resources compared to state-of-the-art compression accelerators while completely removing the memory bottleneck of our accelerator.
Bridging the Gap between Physical and Circuit Analysis for Variability-Aware Microwave Design: Modeling Approaches
Authors: Donati Guerrieri Simona , Ramella Chiara , Catoggio Eva , Bonani Fabrizio
Published: March 2022

Process-induced variability is a growing concern in the design of analog circuits, and in particular for monolithic microwave integrated circuits (MMICs) targeting the 5G and 6G communication systems. The RF and microwave (MW) technologies developed for the deployment of these communication systems exploit devices whose dimension is now well below 100 nm, featuring an increasing variability due to the fabrication process tolerances and the inherent statistical behavior of matter at the nanoscale. In this scenario, variability analysis must be incorporated into circuit design and optimization, with ad hoc models retaining a direct link to the fabrication process and addressing typical MMIC nonlinear applications like power amplification and frequency mixing. This paper presents a flexible procedure to extract black-box models from accurate physics-based simulations, namely TCAD analysis of the active devices and EM simulations for the passive structures, incorporating the dependence on the most relevant fabrication process parameters. We discuss several approaches to extract these models and compare them to highlight their features, both in terms of accuracy and of ease of extraction. We detail how these models can be implemented into EDA tools typically used for RF and MMIC design, allowing for fast and accurate statistical and yield analysis. We demonstrate the proposed approaches extracting the black-box models for the building blocks of a power amplifier in a GaAs technology for X-band applications.
Machine Learning-Based Satellite Routing for SAGIN IoT Networks
Authors: Yuan Xueguang , Liu Jinlin , Du Hang , Zhang Yangan , Li Feisheng , Kadoch Michel
Published: March 2022

Due to limited coverage, radio access provided by ground communication systems is not available everywhere on the Earth. It is necessary to develop a new three-dimensional network architecture in a bid to meet various connection requirements. Space–air–ground integrated networks (SAGINs) offer large coverage, but the communication quality of satellites is often compromised by weather conditions. To solve this problem, we propose an extended extreme learning machine (ELM) algorithm in this paper, which can predict the communication attenuation caused by rainy weather to satellite communication links, so as to avoid large path loss caused by bad weather conditions. Firstly, we use Internet of Things (IoT)-enabled sensors to collect weather-related data. Then, the system feeds the data to the extended ELM model to obtain a category prediction for blockage caused by weather. Finally, this information helps the selection of the data transmission link and thus improves the satellite routing performance.
Visual Positioning System Based on 6D Object Pose Estimation Using Mobile Web
Authors: Kim Ju-Young , Kim In-Seon , Yun Dai-Yeol , Jung Tae-Won , Kwon Soon-Chul , Jung Kye-Dong
Published: March 2022

Recently, the demand for location-based services using mobile devices in indoor spaces without a global positioning system (GPS) has increased. However, to the best of our knowledge, solutions that are fully applicable to indoor positioning and navigation and ensure real-time mobility on mobile devices, such as global navigation satellite system (GNSS) solutions, cannot achieve remarkable researches in indoor circumstances. Indoor single-shot image positioning using smartphone cameras does not require a dedicated infrastructure and offers the advantages of low price and large potential markets owing to the popularization of smartphones. However, existing methods or systems based on smartphone cameras and image algorithms encounter various limitations when implemented in indoor environments. To address this, we designed an indoor visual positioning system for mobile devices that can locate users in indoor scenes. The proposed method uses a smartphone camera to detect objects through a single image in a web environment and calculates the location of the smartphone to find users in an indoor space. The system is inexpensive because it integrates deep learning and computer vision algorithms and does not require additional infrastructure. We present a novel method of detecting 3D model objects from single-shot RGB data, estimating the 6D pose and position of the camera and correcting errors based on voxels. To this end, the popular convolutional neural network (CNN) is improved by real-time pose estimation to handle the entire 6D pose estimate the location and direction of the camera. The estimated position of the camera is addressed to a voxel to determine a stable user position. Our VPS system provides the user with indoor information in 3D AR model. The voxel address optimization approach with camera 6D position estimation using RGB images in a mobile web environment outperforms real-time performance and accuracy compared to current state-of-the-art methods using RGB depth or point cloud.
Assessing the Adoption of Mobile Technology for Commerce by Generation Z
Authors: Puiu Silvia , Demyen Suzana , Tănase Adrian-Costinel , Vărzaru Anca Antoaneta , Bocean Claudiu George
Published: March 2022

E-commerce has gained momentum with the rapid development of technology, and nowadays, we are permanently connected, with constant access to information and a wide range of products. Not only does a desktop computer offer us this possibility, but the latest-generation tablets and mobile phones create a broad framework. This paper investigates Romanian consumers’ attitudes towards adopting mobile technology for commerce (m-commerce), taking into account its development in the last few years, especially among younger generations. The main objectives of the research are to identify the preference for m-commerce use among Generation Z, establish the ways and the devices used by Gen Z individuals to inform about the products and services and order them, and analyze the factors influencing the use of m-commerce applications. The research methodology consists of conducting an empirical analysis using a distributed survey among youngsters from Generation Z in Romania. We used descriptive statistics, such as the analysis of frequency and the mean of variables, artificial neural network analysis (ANN), and multivariate analysis of variance (MANOVA), to validate the hypotheses. The research results indicate a solid inclination for m-commerce among Generation Z. The results are helpful for companies that can shape their marketing strategies to boost their sales using m-commerce channels among the younger population.
A Low-Noise Analog Front End with Interstage Systematically Ambient Interference Cancellation for Pulse Oximeter
Authors: Shen Jiulong , Lin Zhi , Huang Linqing , Ruan Xiukai , Tang Fang
Published: March 2022

This paper presents a low-noise analog front end (AFE) with interstage systematically ambient interference cancellation for a pulse oximeter, which is suitable for clinical oxygen saturation (SPO2) detection with a low perfusion index. The fully differential implementation is adopted to have a better rejection performance of common mode interference and noise. Firstly, the proposed interstage systematically ambient interference cancellation is placed in the two gain stages to decrease low frequency noise in the bandwidth of interest (0.1–20 Hz), so that the larger signal-to-noise ratio (SNR) can be achieved to increase the detection accuracy of this system. Secondly, due to the additional gain stage compared with traditional implementation, the current-reuse OTA is employed to have better noise and power efficiency. Thirdly, the auto zero technique is utilized in the LED Driver to decrease the offset voltage and acquire a larger dynamic range (DR) in the low frequency bandwidth of interest. This PPG AFE chip is designed and fabricated in a 180 nm standard CMOS process. The receiver (RX) of this AFE consumes 220 μW from a 1.8 V supply, and the power consumption of the transmitter (TX) is 60 μW from a 3 V supply. The measurement results show that the input-referred noise current of 2.3 pA/sqrt(Hz) is achieved in RX and 110 dB peak DR is obtained in TX.
Biogenic Amines in Meat and Meat Products: A Review of the Science and Future Perspectives
Authors: Schirone Maria , Esposito Luigi , D’Onofrio Federica , Visciano Pierina , Martuscelli Maria , Mastrocola Dino , Paparella Antonello
Published: March 2022

Biogenic amines (BAs) can be found in a wide range of meat and meat products, where they are important as an index for product stability and quality, but also for their impact on public health. This review analyzes the scientific evidence gathered so far on the presence and role of biogenic amines in meat and meat products, also considering the effect of technological conditions on BAs accumulation or decrease. The data provided can be useful for developing solutions to control BAs formation during the shelf-life, for example by novel starters for dry cured products, as well as by packaging technologies and materials for fresh meats. Further research, whose trends are reviewed in this paper, will fill the knowledge gaps, and allow us to protect such perishable products along the distribution chain and in the home environment.
Effects of Electrical Stimulation of Acupoints on Xerostomia for Patients Who Undergo Hemodialysis
Authors: Yang Li-Yu , Lee Bih-O , Lee Kai-Ni , Chen Chien-An
Published: March 2022

Xerostomia plays a major role in higher interdialytic weight gain (IDWG), which causes cardiovascular complications in patients who undergo hemodialysis. However, few studies have determined a method to manage xerostomia. This study determines the effect of transcutaneous electrical acupoint stimulation (TEAS) on hemodialysis patients with xerostomia and the percentage of IDWG. The study was a single-blind and quasi-experimental study. There are 75 participants: 37 in the TEAS group and 38 in the contrast group. The TEAS group used 250 µs and 50 Hz and the contrast group used 50 µs and 2 Hz three times a week for 3 weeks to stimulate ST 6 and TE17 acupoints. The salivary flow rates, dry mouth, and %IDWG were determined before, during and one week after the program. Compared with the contrast group, the TEAS group showed a significantly improved salivary flow rate (mL/min) (F (2, 123) = 15.28, p < 0.0001), and patients recovered their normal salivary flow rate. However, the results show that both groups showed significant improvement in dry mouth after treatment. The TEAS group demonstrated no effect in terms of %IDWG, as expected. The results show that a TEAS program is an effective means of symptom management for xerostomia patients who undergo hemodialysis. A TEAS program can be used to manage symptoms for xerostomia patients who undergo hemodialysis.
Balance Differences between North and South American Older Adults: A Cross-Sectional, Age and Sex Matched Study
Authors: Souza Matheus Almeida , Goble Daniel , Arney Paige , Vieira Edgar Ramos , Silveira-Nunes Gabriela , Intelangelo Leonardo , Barbosa Michelle Almeida , Barbosa Alexandre Carvalho
Published: March 2022

This study aimed to characterize the risk of falling in low-, moderate- and high-risk participants from two different geographical locations using a portable force-plate. A sample of 390 older adults from South and North America were matched for age, sex, height and weight. All participants performed a standardized balance assessment using a force plate. Participants were classified in low, moderate and high risk of falling. No differences were observed between South and North American men, nor comparing North American men and women. South American women showed the significantly shorter center of pressure path length compared to other groups. The majority of the sample was categorized as having low risk of falling (male: 65.69% and female: 61.87%), with no differences between men and women. Moreover, no differences were found between North vs. South Americans, nor between male and female groups compared separately. In conclusion, South American women had better balance compatible with the status of the 50–59 years’ normative age-range. The prevalence of low falls risk was~61–65%; the prevalence of moderate to high risk was~16–19%. The frequency of fall risk did not differ significantly between North and South Americans, nor between males and females.
Dynamic Evolution Analysis of the Emergency Collaboration Network for Compound Disasters: A Case Study Involving a Public Health Emergency and an Accident Disaster during COVID-19
Authors: Liu Jida , Dong Changqi , An Shi , Mai Qiang
Published: March 2022

Compound disasters are highly complex and can involve different types of disasters. Since the beginning of the COVID-19 pandemic, compound disasters of public health emergencies, accident disasters, and natural hazards have occurred frequently all over the world; therefore, it is important to establish effective compound disaster emergency collaboration networks. Thus, this study examined the 7 March building collapse in Quanzhou City as a case study. This case was a typical compound disaster involving a public health emergency and an accident disaster during COVID-19. Based on the network analysis, the overall response and dynamic characteristics of the emergency collaboration for compound disasters were examined in this study. A compound disaster emergency collaboration network (ECN) was constructed by identifying the interactional relationships between emergency organizations. After applying time slices, the dynamic evolution of network structure, organizational–functional relations, organizational attributes, and cross-organizational relationships were discussed. The research results showed the following: (1) The density and connectivity of the compound disaster ECN first decreased before increasing. Meanwhile, the evolution of the network structure followed a path from decentralized to concentrated and from being uneven to an equilibrium. (2) The characteristics and practices of compound disasters during different periods indicated varied emergency needs for emergency organizations. We found that the formation of emergency tasks not only involved the passive adaptation to match the practice for compound disasters, but also the active choices of emergency organizations when facing compound disasters according to their collective experiences and decisions. (3) The national emergency management departments, the government emergency rescue organizations, and the local governments were the core organizations of the ECN. Public health management departments and social organizations were also required to participate in the ECN to improve the diverse and heterogeneous distribution of resources. (4) With increased demands during a compound disaster emergency, the number of cross-organizational collaborative relationships gradually increased. This study explored compound disaster emergencies from the perspective of network analysis to improve our understanding of the current and developing organizational relationships and practices during a compound disaster event. The dynamic characteristics of compound disasters require efficient adaptation and improvements of the collaborative mechanisms involved during emergencies.
Assessment of the Quality of Saudi Patient Information Leaflets (PILs) Based on the Accuracy of Physical Description and Frequency of Solid Dosage Forms
Authors: Al Hagbani Turki , Alrdaian Dareen , Alshammari Reem Q. , Alshammary Ghaliah , Ansari Mukhtar
Published: March 2022

The physical description of dosage forms is one of the most important considerations in avoiding patient confusion and minimizing medication errors. This study aimed to determine the quality and accuracy of the physical descriptions in patient information leaflets (PILs). This cross-sectional study constituted a total of 200 drugs and PILs that were randomly selected, by pharmacy students, from Al-Dawaa community pharmacies in the Hail region of Saudi Arabia, from January 2021 to July 2021. The drugs and PILs were thoroughly evaluated in accordance with the Gulf Cooperation Council (GCC) guidelines for PILs. The accuracy screening of the total solid dosage forms (capsules + tablets) revealed that 45% showed complete accuracy and compliance, 1.5% showed poor accuracy and compliance, and 53% showed no accuracy and no compliance with the GCC guidelines and the Saudi Food and Drug Authority (SFDA) guidelines. In the frequency test, color, shape, and imprints accounted for 95.6%, 79.1%, and 73.6%, respectively. However, the size of the dosage form was the least (2.2%) used physical description feature. These findings recommend pharmaceutical companies to pay more attention to the written physical description in their PILs. Additionally, the process of PIL approval should be optimized, evaluated, and updated systematically to ensure that they contain the essential information.
Effects of Exogenous Phthalic Acid on Seed Germination, Root Physiological Characteristics, and Mineral Element Absorption of Watermelon
Authors: Li Mengyao , Xiao Jiachang , Lei Fengyun , Zheng Kaimin , Lu Wei , Ma Junying , He Maolin , Zheng Yangxia
Published: March 2022

To understand the effect of exogenous PA on the watermelon root system, the watermelon variety ‘Zaojia 84–24’ was used as experimental material. This study investigated the effects of allelochemicals DIBP and DOP at varying different concentrations (0, 0.05, 0.1, 0.5, 1, and 4 mmol·L−1) on the physiological characteristics and mineral content of watermelon roots. The results revealed that proper PA treatment concentrations (0.05~0.1 mmol·L−1) promoted seed germination, increased the number of RBCs and the survival rate of RBCs, and enhanced the activities of PME and dehydrogenase in watermelon roots. In addition, proper PA treatment concentrations (0.05~0.1 mmol·L−1) promoted the activities of SOD, POD, CAT, and NR in watermelon roots. The contents of MDA and soluble protein were increased at 0.05~4 mmol·L−1 PA. In addition, proper PA treatment concentrations promoted the absorption and accumulation of P, K, Ca, Fe, Cu, and Zn elements in watermelon roots. These results indicate that PA at a concentration of 0.05~0.5 mmol·L−1 can promote watermelon seed germination, improve antioxidant enzyme activity of watermelon roots, and maintain normal physiological activities of watermelon by affecting absorption and accumulation of mineral elements in the root system.
B-GPS: Blockchain-Based Global Positioning System for Improved Data Integrity and Reliability
Authors: Lee Seunghyeon , Seok Hong-Woo , Lee Ki-rim , In Hoh Peter
Published: March 2022

When surveying national reference points using a global positioning system (GPS), appropriate work regulations pertaining to the surveying time must be observed. However, such data can be modified easily, so identifying non-compliance with work regulations and forgeries is challenging. If such incidents occur in cadastral surveys, it may result in financial damages to stakeholders, such as citizens and the state. Therefore, it is necessary to improve the reliability by ensuring the integrity of the GPS positioning data and allowing anyone to track them. In this study, a prototype system was developed to record GPS data and the corrections generated during survey processes using the Ethereum blockchain network. Blockchain is a distributed ledger system that prevents the manipulation of uploaded data without the need for a centralized institution by allowing anyone to check the data. Unlike in the past, the proposed system improves the data integrity and reliability for the entire survey process through blockchain, thereby ensuring transparency of the checks using smart contract addresses.
A Discussion on Winter Indoor Hygrothermal Conditions and Hygroscopic Behaviour of Plasters in Southern Europe
Authors: Ranesi Alessandra , Posani Magda , Veiga Rosário , Faria Paulina
Published: March 2022

In Southern European countries, due to the specific climate, economy and culture, a permanent heating practice during winter is not widely adopted. This may have a significant effect on the performance of indoor coating materials, typically tested considering hygrothermal conditions in the range of 33–75% relative humidity (RH) and 20–25 °C, which are common in continuously heated buildings. In this study, the indoor climate of four bedrooms located in Lisbon, Portugal, was monitored under operational conditions. Based on the data monitored in the case studies, characteristic ranges of indoor hygrothermal conditions were defined and compared to those considered in standard test procedures. In addition, numerical simulations were adopted to compare the hygroscopic performance of four plasters under operational conditions observed on-site. Results show that the four rooms, intermittently heated or unheated, do not provide comfort conditions over 50% of the wintertime, with temperatures lower and RH higher than the ones recommended by the standards. The MBVs resulting from simulations (under operational conditions) are qualitatively in agreement with the MBVs obtained under standard testing conditions. Nonetheless, future studies are recommended to evaluate if standard tests are quantitatively representative of the hygroscopic performance of coating materials in the Southern European scenario.
Off-Label Treatment for Severe Craniomaxillofacial Fractures in Low-Income Countries—A Novel Operation Method with the External Face Fixator
Authors: Deininger Christian , Hofmann Valeska , Necchi Marco , Deininger Susanne , Wichlas Florian
Published: March 2022

Introduction: Craniomaxillofacial fractures (CMF) are common in low-income countries (LIC). Due to limited resources, treatment of these fractures usually consists of interdental wiring or immobilization with a Barton bandage to maintain the reduction by permanent occlusion. These non-surgical treatment methods often lead to unsatisfactory results, such as a disturbed dental occlusion and lockjaw. The aim of this study is to present an off-label treatment option for CMF by applying a hand fixator as external face fixator (EFF) and to demonstrate the surgical method in detail. Materials and Methods: The feasibility and postoperative outcomes of this new off-label operation technique were evaluated by analyzing patients with CMF (n = 13) treated at an NGO hospital in Sierra Leone between 2015 and 2019. Results: The application of the EFF was feasible. The biggest advantage compared to the conventional non-operative methods was, that a dynamic occlusion was still possible during the 6 weeks healing period. Hence, patients could eat and drink almost normally and perform dental hygiene with the EFF in place. We did not discover pintrack infections or other complications. Three patients developed an oronasal fistula due to traumatic a palatal bone loss of about 7–8 mm which was treated by a palatal mucoperiosteal flap 15–20 days after the first operation. Discussion and Conclusions: In LIC, where plate osteosynthesis for CMF cannot be performed due to limited resources the application of an EFF is a promising alternative for a better outcome and an improved quality of life for the patients.
The Use of a Fixed 50:50 Mixture of Nitrous Oxide and Oxygen to Reduce Lumbar Puncture-Induced Pain in the Emergency Department: A Randomized Controlled Trial
Authors: Nicot Mélissandre , Miraillet Ludovic , Pereira Bruno , Bouillon-Minois Jean-Baptiste , Raconnat Julien , Moustafa Farès , Schmidt Jeannot , Sickout-Arondo Sophia , Bernard Lise , Clavelou Pierre , Moisset Xavier
Published: March 2022

Lumbar puncture (LP) is stressful and often painful. We evaluated the efficacy of a fixed 50% nitrous oxide–oxygen mixture (50%N2O-O2) versus placebo to reduce immediate procedural pain and anxiety during LP performed in an emergency setting. We conducted a randomized controlled trial involving adults who needed a cerebrospinal fluid analysis in an emergency department. Patients were randomly assigned to inhale either 50%N2O-O2 or medical air. The primary endpoint, assessed using a numerical scale, was the maximum pain felt by the patient during the procedure and the maximum anxiety and satisfaction as secondary outcomes. Eighty-eight patients were randomized and analyzed (ITT). The maximal pain was 5.0 ± 2.9 for patients receiving air and 4.2 ± 3.0 for patients receiving 50%N2O-O2 (effect-size = −0.27 [−0.69; 0.14], p = 0.20). LP-induced anxiety was 4.7 ± 2.8 vs. 3.7 ± 3.7 (p = 0.13), and the proportion of patients with significant anxiety (score ≥ 4/10) was 72.7% vs. 50.0% (p = 0.03). Overall satisfaction was higher among patients receiving 50%N2O-O2 (7.4 ± 2.4 vs. 8.9 ± 1.6, p < 0.001). No serious adverse events were attributable to 50%N2O-O2 inhalation. Although inhalation of 50%N2O-O2 failed to reduce LP-induced pain in an emergency setting, it tended to reduce anxiety and significantly increased patient satisfaction.
Sleep Health Assessment and Treatment in Children and Adolescents with Chronic Pain: State of the Art and Future Directions
Authors: Law Emily F. , Kim Agnes , Ickmans Kelly , Palermo Tonya M.
Published: March 2022

Sleep is interrelated with the experience of chronic pain and represents a modifiable lifestyle factor that may play an important role in the treatment of children and adolescents with chronic pain. This is a topical review of assessment and treatment approaches to promote sleep health in children and adolescents with chronic pain, which summarizes: relevant and recent systematic reviews, meta-analyses, and methodologically sound prospective studies and clinical trials. Recommendations are provided for best practices in the clinical assessment and treatment of sleep health in youth with chronic pain. This overview can also provide researchers with foundational knowledge to build upon the best evidence for future prospective studies, assessment and intervention development, and novel clinical trials.