bluuebunny/crossref_metadata_2025 huggingface dataset:
Haploidentical stem cell transplantation after a reduced-intensity conditioning regimen for the treatment of advanced hematologic malignancies: posttransplantation CD8-depleted donor lymphocyte infusions contribute to improve T-cell recovery
Authors: Dodero Anna , Carniti Cristiana , Raganato Anna , Vendramin Antonio , Farina Lucia , Spina Francesco , Carlo-Stella Carmelo , Di Terlizzi Simona , Milanesi Marco , Longoni Paolo , Gandola Lorenza , Lombardo Claudia , Corradini Paolo
Published: February 2009

Haploidentical hematopoietic stem cell transplantation provides an option for patients with advanced hematologic malignancies lacking a compatible donor. In this prospective phase 1/2 trial, we evaluated the role of reduced-intensity conditioning (RIC) followed by early add-backs of CD8-depleted donor lymphocyte infusions (DLIs). The RIC regimen consisted of thiotepa, fludarabine, cyclophosphamide, and 2 Gy total body irradiation. Twenty-eight patients with advanced lymphoproliferative diseases (n = 24) or acute myeloid leukemia (n = 4) were enrolled. Ex vivo and in vivo T-cell depletion was carried out by CD34+ cell selection and alemtuzumab treatment. The 2-year cumulative incidence of nonrelapse mortality was 26% and the 2-year overall survival (OS) was 44%, with a better outcome for patients with chemosensitive disease (OS, 75%). Overall, 54 CD8-depleted DLIs were administered to 23 patients (82%) at 3 different dose levels without loss of engraftment or acute toxicities. Overall, 6 of 23 patients (26%) developed grade II-IV graft-versus-host disease, mainly at dose level 2. In conclusion, our RIC regimen allowed a stable engraftment with a rather low nonrelapse mortality in poor-risk patients; OS is encouraging with some long-term remissions in lymphoid malignancies. CD8-depleted DLIs are feasible and promote the immune reconstitution.
AICAR activates the pluripotency transcriptional network in embryonic stem cells and induces KLF4 and KLF2 expression in fibroblasts
Authors: Adamo Luigi , Zhang Yuzhi , García-Cardeña Guillermo
Published: February 2009

Background

Pluripotency, the property of a cell to differentiate into all cellular types of a given organism, is central to the development of stem cell-based therapies and regenerative medicine. Stem cell pluripotency is the result of the orchestrated activation of a complex transcriptional network characterized by the expression of a set of transcription factors including the master regulators of pluripotency Nanog and Oct4. Recently, it has been shown that pluripotency can be induced in somatic cells by viral-mediated expression of the transcription factors Oct3/4, Sox2, Klf4, and c-Myc.

Results

Here we show that 5-Aminoimidazole-4-carboxamide-1-b-riboside (AICAR) is able to activate the molecular circuitry of pluripotency in mouse embryonic stem cells (mESC) and maintain Nanog and Oct4 expression in mESC exposed to the differentiating agent retinoic acid. We also show that AICAR is able to induce Klf4, Klf2 and Myc expression in both mESC and murine fibroblasts.

Conclusion

AICAR is able to activate the molecular circuitry of pluripotency in mESC and to induce the expression of several key regulators of pluripotency in somatic cells. AICAR is therefore a useful pharmacological entity for studying small molecule mediated induction of pluripotency.
Human Papillomaviruses and genital co-infections in gynaecological outpatients
Authors: Verteramo Rosita , Pierangeli Alessandra , Mancini Emanuela , Calzolari Ettore , Bucci Mauro , Osborn John , Nicosia Rosa , Chiarini Fernanda , Antonelli Guido , Degener Anna Marta
Published: February 2009

Background

High grade HPV infections and persistence are the strongest risk factors for cervical cancer. Nevertheless other genital microorganisms may be involved in the progression of HPV associated lesions.

Methods

Cervical samples were collected to search for human Papillomavirus (HPV), bacteria and yeast infections in gynaecologic outpatients. HPV typing was carried out by PCR and sequencing on cervical brush specimens. Chlamydia trachomatis was identified by strand displacement amplification (SDA) and the other microorganisms were detected by conventional methods.

Results

In this cross-sectional study on 857 enrolled outpatients, statistical analyses revealed a significant association of HPV with C. trachomatis and Ureaplasma urealyticum (at high density) detection, whereas no correlation was found between HPV infection and bacterial vaginosis, Streptococcus agalactiae, yeasts, Trichomonas vaginalis and U. urealyticum. Mycoplasma hominis was isolated only in a few cases both in HPV positive and negative women and no patient was infected with Neisseria gonorrhoeae.

Conclusion

Although bacterial vaginosis was not significantly associated with HPV, it was more common among the HPV positive women. A significant association between HPV and C. trachomatis was found and interestingly also with U. urealyticum but only at a high colonization rate. These data suggest that it may be important to screen for the simultaneous presence of different microorganisms which may have synergistic pathological effects.
A single immunization with HA DNA vaccine by electroporation induces early protection against H5N1 avian influenza virus challenge in mice
Authors: Zheng Liyun , Wang Fuyan , Yang Zhongdong , Chen Jianjun , Chang Haiyan , Chen Ze
Published: February 2009

Background

Developing vaccines for the prevention of human infection by H5N1 influenza viruses is an urgent task. DNA vaccines are a novel alternative to conventional vaccines and should contribute to the prophylaxis of emerging H5N1 virus. In this study, we assessed whether a single immunization with plasmid DNA expressing H5N1 hemagglutinin (HA) could provide early protection against lethal challenge in a mouse model.

Methods

Mice were immunized once with HA DNA at 3, 5, 7 days before a lethal challenge. The survival rate, virus titer in the lungs and change of body weight were assayed to evaluate the protective abilities of the vaccine. To test the humoral immune response induced by HA DNA, serum samples were collected through the eye canthus of mice on various days after immunization and examined for specific antibodies by ELISA and an HI assay. Splenocytes were isolated after the immunization to determine the antigen-specific T-cell response by the ELISPOT assay.

Results

Challenge experiments revealed that a single immunization of H5N1 virus HA DNA is effective in early protection against lethal homologous virus. Immunological analysis showed that an antigen-specific antibody and T-cell response could be elicited in mice shortly after the immunization. The protective abilities were correlated with the amount of injected DNA and the length of time after vaccination.

Conclusion

A single immunization of 100 μg H5 HA DNA vaccine combined with electroporation was able to provide early protection in mice against homologous virus infection.
Search for cardiac calcium cycling gene mutations in familial ventricular arrhythmias resembling catecholaminergic polymorphic ventricular tachycardia
Authors: Marjamaa Annukka , Laitinen-Forsblom Päivi , Lahtinen Annukka M , Viitasalo Matti , Toivonen Lauri , Kontula Kimmo , Swan Heikki
Published: February 2009

Background

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a severe inherited cardiac disorder caused by mutations predominantly in the ryanodine receptor (RyR2) gene. We sought to identify mutations in genes affecting cardiac calcium cycling in patients with CPVT and in less typical familial exercise-related ventricular arrhythmias.

Methods and Results

We recruited 33 consecutive patients with frequent ventricular premature complexes (VPCs) without structural heart disease and often history of syncope or sudden death in family. Sixteen of the patients featured a phenotype typical of CPVT. In 17 patients, VPCs emerged also at rest. Exercise stress test and echocardiography were performed to each patient and 232 family members. Familial background was evident in 42% of cases (n = 14). We sequenced all the coding exons of the RyR2, FKBP1B, ATP2A2 and SLC8A1 genes from the index patients. Single channel recordings of a mutant RyR2 were performed in planar lipid bilayers. Two novel RyR2 missense mutations (R1051P and S616L) and two RyR2 exon 3 deletions were identified, explaining 25% of the CPVT phenotypes. A rare variant (N3308S) with open probabilities similar to the wild type channels in vitro, was evident in a patient with resting VPCs. No disease-causing variants were detectable in the FKBP1B, ATP2A2 or SLC8A1 genes.

Conclusion

We report two novel CPVT-causing RyR2 mutations and a novel RyR2 variant of uncertain clinical significance in a patient with abundant resting VPCs. Our data also strengthen the previous assumption that exon 3 deletions of RyR2 should screened for in CPVT and related phenotypes.
Loss of full length CtBP1 expression enhances the invasive potential of human melanoma
Authors: Winklmeier Andreas , Poser Ina , Hoek Keith S , Bosserhoff Anja K
Published: February 2009

Background

The C-terminal binding protein 1 (CtBP1) is a known co-repressor of gene transcription. We recently revealed that CtBP1 expression is lost in melanoma cells and melanoma inhibitory activity (MIA) expression is subsequently increased. The present study was performed to evaluate a more general role of CtBP1 in human melanoma and identify further CtBP1-regulated target genes.

Methods

Sequence analysis and expression profile of CtBP1 in melanoma cell lines were done by PCR. Boyden Chamber assays and co-immunoprecipitation were performed to investigate the functional role of CtBP1. Gene expression analysis and micro array data were used to define target genes.

Results

Interestingly, we detected an alternative splice product of CtBP1 with unknown function whose expression is induced at reduction of full length CtBP1. Overexpression of full length CtBP1 in melanoma cells had no effect on cell proliferation but did influence cell migration and invasiveness. To understand the effect of CtBP1 we identified putative LEF/TCF target genes found to be strongly expressed in melanoma using DNA microarray analysis. We focused on fourteen genes not previously associated with melanoma. Detailed analysis revealed that most of these were known to be involved in tumor metastasis. Eleven genes had expression profiles associated with melanoma cell invasiveness.

Conclusion

In summary, this study revealed that reduction of CtBP1 expression is correlated with migratory, invasive potential of melanoma cells.
Process evaluation of a community-based program for prevention and control of non-communicable disease in a developing country: The Isfahan Healthy Heart Program, Iran
Authors: Rabiei Katayoun , Kelishadi Roya , Sarrafzadegan Nizal , Abedi Heidar Ali , Alavi Mousa , Heidari Kamal , Bahonar Ahmad , Boshtam Maryam , Zare Karim , Sadeghi Shahryar
Published: February 2009

Background

Cardiovascular diseases are the most common cause of mortality in Iran. A six-year, comprehensive, integrated community-based demonstration study entitled Isfahan Healthy Heart Program (IHHP) conducted in Iran, and it started in 2000. Evaluation and monitoring are integrated parts of this quasi-experimental trial, and consists of process, as well as short and long-term impact evaluations. This paper presents the design of the "process evaluation" for IHHP, and the results pertaining to some interventional strategies that were implemented in workplaces

Methods

The process evaluation addresses the internal validity of IHHP by ascertaining the degree to which the program was implemented as intended. The IHHP process evaluation is a triangulated study conducted for all interventions at their respective venues. All interventional activities are monitored to determine why and how some are successful and sustainable, to identify mechanisms as well as barriers and facilitators of implementation.

Results

The results suggest that factory workers and managers are satisfied with the interventions. In the current study, success was mainly shaped by the organizational readiness and timing of the implementation. Integrating most of activities of the project to the existing ongoing activities of public health officers in worksites is suggested to be the most effective means of implementation of the health promoting activities in workplaces.

Conclusion

The results of our experience may help other developing countries to plan for similar interventions.
Interstitial pneumonitis following intrapleural chemotherapy
Authors: Zappa Luis , Savady Renaldo , Humphries Gary N , Sugarbaker Paul H
Published: February 2009

Background

Mucinous neoplasms within the abdomen may disseminate by direct extension through the diaphragm to involve the pleural space. Treatment of this condition is by parietal and visceral pleurectomy followed by hyperthermic intrapleural chemotherapy.

Case presentation

In this case report a patient developed persistent right upper lobe interstitial pneumonitis and progressive parenchymal fibrosis following intrapleural chemotherapy treatment with mitomycin C and doxrubicin. The condition persisted until death 28 months later. Death was from progressive intraabdominal disease with intestinal obstruction and sepsis associated with progressive pulmonary parenchymal disease. The right pleural space disease did not recur.

Conclusion

This manuscript is the first case report describing interstitial pneumonitis and lung fibrosis following intrapleural chemotherapy. Since pulmonary toxicity from chemotherapy is a dose-dependent phenomenon, dose reduction of intrapleural as compared to intraperitoneal hyperthermic chemotherapy may be necessary.
Enhanced Pre-Synaptic Glutamate Release in Deep-Dorsal Horn Contributes to Calcium Channel Alpha-2-Delta-1 Protein-Mediated Spinal Sensitization and Behavioral Hypersensitivity
Authors: Nguyen David , Deng Ping , Matthews Elizabeth A , Kim Doo-Sik , Feng Guoping , Dickenson Anthony H , Xu Zao C , Luo Z David
Published: February 2009

Nerve injury-induced expression of the spinal calcium channel alpha-2-delta-1 subunit (Cavα2δ1) has been shown to mediate behavioral hypersensitivity through a yet identified mechanism. We examined if this neuroplasticity modulates behavioral hypersensitivity by regulating spinal glutamatergic neurotransmission in injury-free transgenic mice overexpressing the Cavα2δ1proteins in neuronal tissues. The transgenic mice exhibited hypersensitivity to mechanical stimulation (allodynia) similar to the spinal nerve ligation injury model. Intrathecally delivered antagonists for N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxyl-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptors, but not for the metabotropic glutamate receptors, caused a dose-dependent allodynia reversal in the transgenic mice without changing the behavioral sensitivity in wild-type mice. This suggests that elevated spinal Cavα2δ1mediates allodynia through a pathway involving activation of selective glutamate receptors. To determine if this is mediated by enhanced spinal neuronal excitability or pre-synaptic glutamate release in deep-dorsal horn, we examined wide-dynamic-range (WDR) neuron excitability with extracellular recording and glutamate-mediated excitatory postsynaptic currents with whole-cell patch recording in deep-dorsal horn of the Cavα2δ1transgenic mice. Our data indicated that overexpression of Cavα2δ1in neuronal tissues led to increased frequency, but not amplitude, of miniature excitatory post synaptic currents mediated mainly by AMPA/kainate receptors at physiological membrane potentials, and also by NMDA receptors upon depolarization, without changing the excitability of WDR neurons to high intensity stimulation. Together, these findings support a mechanism of Cavα2δ1-mediated spinal sensitization in which elevated Cavα2δ1causes increased pre-synaptic glutamate release that leads to reduced excitation thresholds of post-synaptic dorsal horn neurons to innocuous stimuli. This spinal sensitization mechanism may mediate at least partially the neuropathic pain states derived from increased pre-synaptic Cavα2δ1expression.
Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size inDrosophila
Authors: Demontis Fabio , Perrimon Norbert
Published: February 2009

Drosophila larval skeletal muscles are single, multinucleated cells of different sizes that undergo tremendous growth within a few days. The mechanisms underlying this growth in concert with overall body growth are unknown. We find that the size of individual muscles correlates with the number of nuclei per muscle cell and with increasing nuclear ploidy during development. Inhibition of Insulin receptor (InR; Insulin-like receptor)signaling in muscles autonomously reduces muscle size and systemically affects the size of other tissues, organs and indeed the entire body, most likely by regulating feeding behavior. In muscles, InR/Tor signaling, Foxo and dMyc(Diminutive) are key regulators of endoreplication, which is necessary but not sufficient to induce growth. Mechanistically, InR/Foxo signaling controls cell cycle progression by modulating dmyc expression and dMyc transcriptional activity. Thus, maximal dMyc transcriptional activity depends on InR to control muscle mass, which in turn induces a systemic behavioral response to allocate body size and proportions.
Primary cilia regulate Shh activity in the control of molar tooth number
Authors: Ohazama Atsushi , Haycraft Courtney J. , Seppala Maisa , Blackburn James , Ghafoor Sarah , Cobourne Martyn , Martinelli David C. , Fan Chen-Ming , Peterkova Renata , Lesot Herve , Yoder Bradley K. , Sharpe Paul T.
Published: February 2009

Primary cilia mediate Hh signalling and mutations in their protein components affect Hh activity. We show that in mice mutant for a cilia intraflagellar transport (IFT) protein, IFT88/polaris, Shh activity is increased in the toothless diastema mesenchyme of the embryonic jaw primordia. This results in the formation of ectopic teeth in the diastema, mesial to the first molars. This phenotype is specific to loss of polaris activity in the mesenchyme since loss of Polaris in the epithelium has no detrimental affect on tooth development. To further confirm that upregulation of Shh activity is responsible for the ectopic tooth formation, we analysed mice mutant for Gas1, a Shh protein antagonist in diastema mesenchyme. Gas1mutants also had ectopic diastema teeth and accompanying increased Shh activity. In this context, therefore, primary cilia exert a specific negative regulatory effect on Shh activity that functions to repress tooth formation and thus determine tooth number. Strikingly, the ectopic teeth adopt a size and shape characteristic of premolars, a tooth type that was lost in mice around 50-100 million years ago.
Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation
Authors: Akhtar Nasreen , Marlow Rebecca , Lambert Elise , Schatzmann Franziska , Lowe Emma T. , Cheung Julia , Katz Elad , Li Weiping , Wu Chuanyue , Dedhar Shoukat , Naylor Matthew J. , Streuli Charles H.
Published: February 2009

Cell-matrix adhesion is essential for the development and tissue-specific functions of epithelia. For example, in the mammary gland, β1-integrin is necessary for the normal development of alveoli and for the activation of endocrine signalling pathways that determine cellular differentiation. However, the adhesion complex proteins linking integrins with downstream effectors of hormonal signalling pathways are not known. To understand the mechanisms involved in connecting adhesion with this aspect of cell phenotype,we examined the involvement of two proximal β1-integrin signalling intermediates, integrin-linked kinase (ILK) and focal adhesion kinase (FAK). By employing genetic analysis using the Cre-LoxP system, we provide evidence that ILK, but not FAK, has a key role in lactogenesis in vivo and in the differentiation of cultured luminal epithelial cells. Conditional deletion of ILK both in vivo and in primary cell cultures resulted in defective differentiation, by preventing phosphorylation and nuclear translocation of STAT5, a transcription factor required for lactation. Expression of an activated RAC (RAS-related C3 botulinum substrate) in ILK-null acini restored the lactation defect, indicating that RAC1 provides a mechanistic link between the integrin/ILK adhesion complex and the differentiation pathway. Thus, we have determined that ILK is an essential downstream component of integrin signalling involved in differentiation, and have identified a high degree of specificity within the integrin-based adhesome that links cell-matrix interactions with the tissue-specific function of epithelia.
Themore and smaller cellsmutants ofArabidopsis thalianaidentify novel roles forSQUAMOSA PROMOTER BINDING PROTEIN-LIKEgenes in the control of heteroblasty
Authors: Usami Takeshi , Horiguchi Gorou , Yano Satoshi , Tsukaya Hirokazu
Published: February 2009

Regulation of cell number and cell size is essential for controlling the shape and size of leaves. Here, we report a novel class of Arabidopsis thaliana mutants, more and smaller cells 1(msc1)-msc3, which have increased cell number and decreased cell size in leaves. msc1 has a miR156-resistant mutation in the SQUAMOSA PROMOTER BINDING PROTEIN-LIKE 15 (SPL15) gene. msc2 and msc3 are new alleles of paused and squint mutants, respectively. All msc mutants showed accelerated heteroblasty, a phenomenon in which several morphological traits of leaves change along with phase change. Consistent with this finding, in the wild type, leaves at higher nodes (adult leaves) also have increased cell number and reduced cell size compared with those at lower nodes (juvenile leaves). These facts indicate that precocious acquisition of adult leaf characteristics in the msc mutants may cause alterations in the number and size of cells, and that heteroblasty plays an important role in the regulation of cell number and size. In agreement with this suggestion, such heteroblasty-associated changes in cell number and size are severely inhibited by the constitutive overexpression of miR156 and are promoted by the elevated expression of miR156-insensitive forms of SPLgenes. By contrast, rdr6, sgs3, zip, arf3 and arf4mutations, which affect progression of heteroblasty, had little or no effect on number or size of cells. These results suggest that cell number and size are mainly regulated by an SPL-dependent pathway rather than by a tasiR-ARF-dependent pathway.
An UNC-40 pathway directs postsynaptic membrane extension inCaenorhabditis elegans
Authors: Alexander Mariam , Chan Kevin Ka Ming , Byrne Alexandra B. , Selman Guillermo , Lee Teresa , Ono Jasmine , Wong Eric , Puckrin Rachel , Dixon Scott J. , Roy Peter John
Published: February 2009

The postsynaptic membrane of the embryonic neuromuscular junction undergoes a dramatic expansion during later development to facilitate the depolarization of larger muscles. In C. elegans, the postsynaptic membrane resides at the termini of plasma membrane extensions called muscle arms. Membrane extension to the motor axons during larval development doubles the number of muscle arms, making them a tractable model to investigate both postsynaptic membrane expansion and guided membrane extension. To identify genes required for muscle arm extension, we performed a forward screen for mutants with fewer muscle arms. We isolated 23 mutations in 14 genes, including unc-40/Dcc, which encodes a transmembrane receptor that guides the migration of cells and extending axons in response to the secreted UNC-6/Netrin spatial cue. We discovered that UNC-40 is enriched at muscle arm termini and functions cell-autonomously to direct arm extension to the motor axons. Surprisingly, UNC-6 is dispensable for muscle arm extension, suggesting that UNC-40 relies on other spatial cues to direct arm extension. We provide the first evidence that the guanine-nucleotide exchange factor UNC-73/Trio,members of the WAVE actin-polymerization complex, and a homolog of the focal adhesion complex can function downstream of UNC-40 to direct membrane extension. Our work is the first to define a pathway for directed muscle membrane extension and illustrates that axon guidance components can play key roles in postsynaptic membrane expansion.
Smed-Evi/Wntless is required for β-catenin-dependent and-independent processes during planarian regeneration
Authors: Adell Teresa , Salò Emili , Boutros Michael , Bartscherer Kerstin
Published: February 2009

Planarians can regenerate a whole animal from only a small piece of their body, and have become an important model for stem cell biology. To identify regenerative processes dependent on Wnt growth factors in the planarian Schmidtea mediterranea (Smed), we analyzed RNAi phenotypes of Evi, a transmembrane protein specifically required for the secretion of Wnt ligands. We show that, during regeneration, Smed-evi loss-of-function prevents posterior identity, leading to two-headed planarians that resemble Smed-β-catenin1 RNAi animals. In addition, we observe regeneration defects of the nervous system that are not found after Smed-β-catenin1 RNAi. By systematic knockdown of all putative Smed Wnts in regenerating planarians, we identify Smed-WntP-1 and Smed-Wnt11-2 as the putative posterior organizers, and demonstrate that Smed-Wnt5 is a regulator of neuronal organization and growth. Thus, our study provides evidence that planarian Wnts are major regulators of regeneration, and that they signal through β-catenin-dependent and-independent pathways.
Educational Debt Burden and Career Choice: Evidence from a Financial Aid Experiment at NYU Law School
Authors: Field Erica
Published: February 2009

This paper examines the influence of psychological responses to debt on career choices from an experiment in which alternative financial aid packages were assigned by lottery to a set of law school admits. The packages had equivalent monetary value, but one required the student to take on a loan that would be paid for by the school if he worked in public interest law, while the other covered tuition as long as the student worked in public interest law. If he did not, the student would be required to reimburse the school. Tuition assistance recipients have a 36 to 45 percent higher public interest placement rate and, when lottery results were announced before enrollment, were twice as likely to enroll. (JEL I21, I22, J44, D14)
Many Children Left Behind? Textbooks and Test Scores in Kenya
Authors: Glewwe Paul , Kremer Michael , Moulin Sylvie
Published: February 2009

A randomized evaluation in rural Kenya finds, contrary to the previous literature, that providing textbooks did not raise average test scores. Textbooks did increase the scores of the best students (those with high pretest scores) but had little effect on other students. Textbooks are written in English, most students' third language, and many students could not use them effectively. More generally, the curriculum in Kenya, and in many other developing countries, tends to be oriented toward academically strong students, leaving many students behind in societies that combine a centralized educational system; the heterogeneity in student preparation associated with rapid educational expansion; and disproportionate elite power. (JEL O15, I21, I28, J13)
Fixing Market Failures or Fixing Elections? Agricultural Credit in India
Authors: Cole Shawn
Published: February 2009

This paper integrates theories of political budget cycles with theories of tactical electoral redistribution to test for political capture in a novel way. Studying banks in India, I find that government-owned bank lending tracks the electoral cycle, with agricultural credit increasing by 5–10 percentage points in an election year. There is significant cross-sectional targeting, with large increases in districts in which the election is particularly close. This targeting does not occur in nonelection years or in private bank lending. I show capture is costly: elections affect loan repayment, and election-year credit booms do not measurably affect agricultural output. (JEL D72, O13, O17, Q14, Q18)
Trade and the Diffusion of the Industrial Revolution
Authors: Lucas Robert E
Published: February 2009

This paper proposes a model to describe the evolution of real gross domestic product (GDP) in the world economy that is intended to apply to all open economies. The parameters of the model are calibrated using evidence from Sachs and Warner on economies classed as open, from Parente and Prescott on economies that have successfully begun to develop, and from Kuznets and the World Bank on the employment share of agriculture in various times and places. The theory predicts convergence of the income levels and growth rates in the open economies and has strong but reasonable implications for transition dynamics. (JEL F41, O33, O47)
Civic Virtue and Labor Market Institutions
Authors: Algan Yann , Cahuc Pierre
Published: February 2009

We argue civic virtue plays a key role in explaining the design of public insurance against unemployment risks by solving moral hazard issues which hinder the efficiency of unemployment insurance. We show, in a simple model, that economies with stronger civic virtues are more prone to provide insurance through unemployment benefits rather than through job protection. We provide cross-country empirical evidence of a strong correlation between civic attitudes and the design of unemployment benefits and employment protection in OECD countries over the period 1980 to 2003. We then use an epidemiological approach to estimate the existence of a potential causal relationship from inherited civic virtue to labor market insurance institutions. (JEL: J41, J65, J68, Z13)
New Keynesian Models: Not Yet Useful for Policy Analysis
Authors: Chari V. V , Kehoe Patrick J , McGrattan Ellen R
Published: February 2009

Macroeconomists have largely converged on method, model design, reduced-form shocks, and principles of policy advice. Our main disagreements today are about implementing the methodology. Some think New Keynesian models are ready to be used for quarter-to-quarter quantitative policy advice. We do not. Focusing on the state-of-the-art version of these models, we argue that some of its shocks and other features are not structural or consistent with microeconomic evidence. Since an accurate structural model is essential to reliably evaluate the effects of policies, we conclude that New Keynesian models are not yet useful for policy analysis. (JEL E12, E60)
On the Sources of the Great Moderation
Authors: Galí Jordi , Gambetti Luca
Published: February 2009

The Great Moderation in the US economy has been accompanied by large changes in the comovements among output, hours, and labor productivity. Those changes are reflected in both conditional and unconditional second moments as well as in the impulse responses to identified shocks. Among other changes, our findings point to an increase in the volatility of hours relative to output, a shrinking contribution of nontechnology shocks to output volatility, and a change in the cyclical response of labor productivity to those shocks. That evidence suggests a more complex picture than that associated with “good luck” explanations of the Great Moderation. (JEL: E23, E24, J22, J24)
The Ins and Outs of Cyclical Unemployment
Authors: Elsby Michael W. L , Michaels Ryan , Solon Gary
Published: February 2009

A dominant trend in recent modeling of labor market fluctuations is to treat unemployment inflows as acyclical. This trend has been encouraged by recent influential papers that stress the role of longer unemployment spells, rather than more unemployment spells, in accounting for recessionary unemployment. After reviewing an empirical literature going back several decades, we apply a convenient log change decomposition to Current Population Survey data to characterize rising unemployment in each postwar recession. We conclude that a complete understanding of cyclical unemployment requires an explanation of countercyclical inflow rates, especially for job losers (layoffs), as well as procyclical outflow rates. (JEL E24, E32)
Like Father, Like Son: Social Network Externalities and Parent-Child Correlation in Behavior
Authors: Calvó-Armengol Antoni , Jackson Matthew O
Published: February 2009

We build an overlapping generations model where an individual sees higher returns to adopting a behavior as many neighbors adopt the behavior. We show that overlap in the state of a parent and child's neighborhood can lead to correlation in parent-child behavior independent of any parent-child interaction. Increasing the sensitivity of individual decisions to the state of their social community leads to increased parent-child correlation and less efficient (more costly) behavior on average in the society. We show this model is distinguished from a direct parental influence model, in that it predicts increased generational effects, implying residual correlation between children and grandparents after including parental information. (JEL J12, J13, Z13)
Asymmetric Networks in Two-Sided Markets
Authors: Ambrus Attila , Argenziano Rossella
Published: February 2009

This paper investigates pricing decisions and network choices in two-sided markets with network externalities. Consumers are heterogeneous in how much they value the externality. Imposing restrictions on the extent of coordination failure among consumers generates clear qualitative conclusions about equilibrium market configurations. Multiple asymmetric networks can coexist in equilibrium, both in the case of a monopolist network provider and in the case of competing providers. These equilibria have the property that one network is cheaper and larger on one side, while the other network is cheaper and larger on the other side. Product differentiation is endogenized by consumers' network choices. (JEL D85, L12, L13, L14, D42, D43)
Veto Constraint in Mechanism Design: Inefficiency with Correlated Types
Authors: Compte Olivier , Jehiel Philippe
Published: February 2009

We consider bargaining problems in which parties have access to outside options, the size of the pie is commonly known and each party privately knows the realization of her outside option. We allow for correlations in the distributions of outside options. Parties have a veto right, which allows them to obtain at least their outside option payoff in any event. Besides, agents can receive no subsidy ex post. We show that inefficiencies are inevitable whatever the exact form of correlation, as long as private information is dispersed. We also illustrate how veto constraints differ from ex post participation constraints. (JEL C78, D82)
Contracting with Third Parties
Authors: Baliga Sandeep , Sjöström Tomas
Published: February 2009

In bilateral holdup and moral hazard in teams models, introducing a third party allows implementation of the first best, even if renegotiation is possible. Fines paid to the third party provide incentives for truth-telling and investment. This result holds even if the third party is corruptible, as long as the grand coalition has access to the same contracting technology as any colluding subcoalition. (JEL D86, D82)
Optimal Tax Design and Enforcement with an Informal Sector
Authors: Boadway Robin , Sato Motohiro
Published: February 2009

An optimal commodity tax approach is taken to compare trade taxes and VATs when some commodities are produced informally. Trade taxes apply to all imports and exports, including intermediate goods, while the VAT applies only to sales by the formal sector and imports. The VAT achieves production efficiency within the formal sector, but, unlike trade taxes, cannot indirectly tax profits. Making the size of the informal sector endogenous in each regime is potentially decisive. The ability of the government to change the size of the informal sector through costly enforcement may also tip the balance in favor of the VAT. (JEL E26, H21, H25)
Greenhouse Gas Reductions under Low Carbon Fuel Standards?
Authors: Holland Stephen P , Hughes Jonathan E , Knittel Christopher R
Published: February 2009

A low carbon fuel standard (LCFS) seeks to reduce greenhouse gas emissions by limiting the carbon intensity of fuels. We show this decreases high carbon fuel production but increases low carbon fuel production, possibly increasing net carbon emissions. The LCFS cannot be efficient, and the best LCFS may be nonbinding. We simulate a national LCFS on gasoline and ethanol. For a broad parameter range, emissions decrease, energy prices increase, abatement costs are large ($80–$760 billion annually), and average abatement costs are large ($307–$2,272 per CO2metric ton). A cost effective policy has much lower average abatement costs ($60–$868). (JEL Q54, Q58)
Domestic Effects of the Foreign Activities of US Multinationals
Authors: Desai Mihir A , Foley C. Fritz , Hines James R
Published: February 2009

Do firms investing abroad simultaneously reduce their domestic activity? This paper analyzes the relationship between the domestic and foreign operations of US manufacturing firms between 1982 and 2004 by instrumenting for changes in foreign operations with GDP growth rates of the foreign countries in which they invest. Estimates produced using this instrument indicate that 10 percent greater foreign investment is associated with 2.6 percent greater domestic investment, and 10 percent greater foreign employee compensation is associated with 3.7 percent greater domestic employee compensation. These results do not support the popular notion that expansions abroad reduce a firm's domestic activity, instead suggesting the opposite. (JEL F23, H25, L25)
Details Matter: The Impact of Presentation and Information on the Take-up of Financial Incentives for Retirement Saving
Authors: Saez Emmanuel
Published: February 2009

We examine the effects of presentation and information on the take-up of financial subsidies for retirement saving in a large randomized experiment carried out with H&R Block. The subsidies raise take-up and contributions with larger effects when the subsidy is characterized as a matching contribution rather than an equivalent-value tax credit (or cash back), and when filers are informed before the tax season about the subsidy. The results imply that both pure incentives and the presentation of those incentives affect consumer choices. (JEL D14, H24, H31, J26)
Who Misvotes? The Effect of Differential Cognition Costs on Election Outcomes
Authors: Shue Kelly , Luttmer Erzo F. P
Published: February 2009

If voters have negligible cognition costs, ballot layout should not affect election outcomes. We explore deviations from rational voting using quasi-random variation in candidate name placement on ballots from the 2003 California recall election. We find that minor candidates' vote shares almost double when their names are adjacent to the names of major candidates. All else equal, vote share gains are larger in precincts with higher percentages of poorly educated, poor, or third-party voters. A major candidate that disproportionally attracts voters from such precincts faces an electoral disadvantage. We also explore which voting technology platforms and brands mitigate misvoting. (JEL D72)
Housing, Health, and Happiness
Authors: Cattaneo Matias D , Galiani Sebastian , Gertler Paul J , Martinez Sebastian , Titiunik Rocio
Published: February 2009

We investigate the impact of a large-scale Mexican program to replace dirt floors with cement floors on child health and adult happiness. We find that replacing dirt floors with cement significantly improves the health of young children measured by decreases in the incidence of parasitic infestations, diarrhea, and the prevalence of anemia, and an improvement in children's cognitive development. Additionally, we find significant improvements in adult welfare measured by increased satisfaction with their housing and quality of life, as well as by lower scores on depression and perceived stress scales. (JEL I12, I31, J13, O15)
Assessment of Functional Capacity: An Investigation on the Benefits of Combining Ability-Predicted and Work-Simulated Work Samples
Authors: Lee Gloria K. , Tansey Timothy N. , Ferrin James M. , Parashar Divya , Frain Michael P. , Tschopp Molly K. , Adams Nancy
Published: February 2009

Rehabilitation professionals have long used work samples in assessing the ability and functionality of clients requesting rehabilitation services. Although there has been remarkable development in the type and scope of work samples, the incorporation of work samples into assessment has lagged behind that of other measurement systems. One logical reason is the prolonged time required to administer work samples. Despite this time commitment, work samples have usefulness and value for rehabilitation counselling and vocational evaluation. The purpose of this brief report is to provide evidence to indicate the usefulness of work-simulated work samples versus ability-predicted work samples. The authors discussed the advantages and disadvantages of both assessment approaches in demonstrating the benefits in vocational assessment for clients and professionals.
Effect of Combining Cognitive Behavioural Therapy With a Lifestyle Program in Assisting the Unemployed: A Pilot Program
Authors: Coppins Tara , Skinner Denise
Published: February 2009

Psychological obstacles often impede the unemployed from finding work. The current study was aimed at investigating the effectiveness of a combined cognitive–behavioural therapy (CBT) and lifestyle program when applied to an unemployed population from a Disability Employment Network (DEN) provider. CBT focuses on the relationship between an individual's thoughts, feelings and behaviours. The lifestyle program was developed to assess and provide psycho-education on sleep, diet, exercise and social habits. Eight participants completed a questionnaire and interview prior to and following participation in the lifestyle program. Measures included the Beck Depression Inventory (BDI), Rosenberg Self-Esteem scale (RSES), Life Orientation Test (LOT), Self-Efficacy Rating scale, one-on-one interview and participation in the lifestyle program. Key workers participated in a one-on-one interview and rated their perception of their participants' engagement in the job search process. Results were analysed using quantitative and qualitative methodologies. Levels of depressive symptomatology and optimism were not seen to improve, however, levels of self-esteem and ratings of engagement in the job search process did. Inclusion of the lifestyle component appeared to yield promising results for future studies. Further research into application of qualitative analysis in unemployment research is recommended.
Putting the ‘Human’ Back in Genetics: Modeling the Extended Kinships of Twins
Authors: Eaves Lindon
Published: February 2009

Few papers have attempted to address the potential of extended kinships of twins to resolve the complexities of biological and cultural inheritance in humans. Since the mid-80s these issues have largely been buried beneath the quest for specific genes that contribute to individual differences in complex traits and liability to disease. The articles of Keller et al. and Medland and Keller (current issue) revisit these issues. History will decide whether these new papers represent the final gasp of a paradigm superceded by the ‘new’ genetics or contain the timely seeds of new birth in the face of a 30-year genetic research program otherwise poised on the cusp of degeneration (Lakatos & Musgrave, 1970).
Effects of 32-Year Leisure Time Physical Activity Discordance in Twin Pairs on Health (TWINACTIVE Study): Aims, Design and Results for Physical Fitness
Authors: Leskinen Tuija , Waller Katja , Mutikainen Sara , Aaltonen Sari , Ronkainen Paula H. A. , Alén Markku , Sipilä Sarianna , Kovanen Vuokko , Perhonen Merja , Pietiläinen Kirsi H , Cheng Sulin , Suominen Harri , Kainulainen Heikki , Kaprio Jaakko , Kujala Urho M
Published: February 2009

The physically active lifestyle is associated with low future morbidity and mortality, but the causality between physical activity and health is not always clear. As some inherited biological characteristics and childhood experiences may cause selection bias in observational studies, we sought to take them into account by identifying 16 twin pairs (7 MZ, 9 DZ, mean age 60 years) discordant for leisure time physical activity habits for thirty years. We conducted detailed health-related examinations among these twin pairs. Our main aims were to study the effects of physical activity and genes on fitness and body composition, with special reference to body fat compartments, metabolic syndrome components and related diseases and risk factor levels, status of arteries, structure and function of the heart, bone properties, and muscle and fat tissue-related mechanisms linked to physical activity and chronic disease development. Our physical activity assessments showed that inactive co-twins were on average 8.8 MET hours/day less active than their active co-twins through out their midlife (2.2 ± 2.3 vs. 11.0 ± 4.1 MET h/day, p < .001). Follow-up fitness tests showed that physically inactive co-twins were less fit than their active co-twins (estimated VO2peak 26.4 ± 4.9 vs. 32.5 ± 5.5 ml/kg/min, p < .001). Similar differences were found in both MZ and DZ pairs. On the basis of earlier epidemiological observations on nonrelated individuals, these physical activity and fitness differences are large enough to cause differences in many mechanisms and risk factors related to the development of chronic diseases and to permit future analyses.
Comparisons of Refractive Errors Between Twins and Singletons in Chinese School-Age Samples
Authors: Hur Yoon-Mi , Zheng Yingfeng , Huang Wenyong , Ding Xiaohu , He Mingguang
Published: February 2009

Studies have reported that refractive errors are associated with premature births. As twins have higher prevalence of prematurity than singletons, it is important to assess similarity of the prevalence of refractive errors in twins and singletons for proper interpretations and generalizations of the findings from twin studies. We compared refractive errors and diopter hours between 561 pairs of twins and 3757 singletons who are representative of school-age children (7–15 years) residing in an urban area of southern China. We found that the means and variances of the continuous measurement of spherical equivalent refractive error and diopter hours were not significantly different between twins and singletons. Although the prevalence of myopia was comparable between twins and singletons, that of hyperopia and astigmatism was slightly but significantly higher in twins than in singletons. These results are inconsistent with those of adult studies that showed no differences in refractive errors between twins and singletons. Given that the sample size of twins is relatively small and that this study is the first to demonstrate minor differences in refractive errors between twins and singletons, future replications are necessary to determine whether the slightly higher prevalence of refractive errors in twins than in singletons found in this study was due to a sampling error or to the developmental delay often observed in twins in childhood.
Reviews
Authors: Stirling Liz , Wood John , Pritchard Gary
Published: February 2009

Illustration. A Theoretical and Contextual Perspective, Alan Male (2007) SA: AVA Publishing, distributed by Thames and Hudson, 181a High Holborn, London, WC1V 7QX, UK, 020 7845 5000, www.thamesandhudson.com
ISBN 2-940373-51-5, Price 24.95

Left to Right: The Cultural Shift from Words to Pictures, David Crow (2006) AVA Publishing SA (23 Oct 2006), ISBN-10: 2940373361, ISBN-13: 978-2940373369, Hardback/Paperback, 24.95

The Student Experience in Art and Design Higher Education:
Drivers for Change, edited by Linda Drew (2008) Cambridge: Jill Rogers Associates, 209 pp., ISBN 0-954-71117-3