bluuebunny/crossref_metadata_2025 huggingface dataset:
Decoration of Anti-CD38 on Nanoparticles Carrying a STAT3 Inhibitor Can Improve the Therapeutic Efficacy Against Myeloma
Authors: Huang Yung-Hsing , Vakili Mohammad , Molavi Ommoleila , Morrissey Yuen , Wu Chengsheng , Paiva Igor , Soleimani Amir , Lavasanifar Afsaneh , Lai Raymond
Published: January 2019

STAT3 is an oncoprotein which has been shown to contribute to drug resistance in multiple myeloma (MM). Nonetheless, the clinical utility of STAT3 inhibitors in treating MM has been limited, partly related to some of their pharmacologic properties. To overcome these challenges, our group had previously packaged STAT3 inhibitors using a novel formulation of nanoparticles (NP) and found encouraging results. In this study, we aimed to further improve the pharmacologic properties of these NP by decorating them with monoclonal anti-CD38 antibodies. NP loaded with S3I-1757 (a STAT3 inhibitor), labeled as S3I-NP, were generated. S3I-NP decorated with anti-CD38 (labeled as CD38-S3I-NP) were found to have a similar nanoparticular size, drug encapsulation and loading as S3I-NP. The release of S3I-1757 at 24 hours was also similar between the two formulations. Using Cy5.5 labeling of the NP, we found that the decoration of anti-CD38 on these NP significantly increased the cellular uptake by two MM cell lines (p<0.001). Accordingly, CD38-S3I-NP showed a significantly lower inhibitory concentration at 50% (IC50) compared to S3I-NP in two IL6-stimulated MM cell lines (p<0.001). In a xenograft mouse model, CD38-S3I-NP significantly reduced the tumor size by 4 folds compared to S3I-NP on day 12 after drug administration (p=0.006). The efficacy of CD38-S3I-NP in suppressing STAT3 phosphorylation in the xenografts was confirmed by using immunocytochemistry and western blot analysis. In conclusion, our study suggests that the decoration of anti-CD38 on NP loaded with STAT3 inhibitors can further improve their therapeutic effects against MM.
Colloidal Metal Oxide Nanoparticles Prepared by Laser Ablation Technique and Their Antibacterial Test
Authors: Duque Johan , Moreno Brayan , Avila Yenny , Riascos Henry
Published: January 2019

We report the production of metal oxide (TiFe2O4, ZnFe2O4) nanoparticles by pulsed laser ablation technique in liquid environment. We used nano second Nd: YAG   laser systems working at 532 nm and 1064 nm of wavelength, the energy of the laser beam was kept constant at 80 mJ. Absorbance spectra, surface plasmon resonance, optical band-gap and nanoparticle morphology were investigated using ultraviolet-visible (UV-Vis) spectroscopy, Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Changing the wavelength of the laser for growth, nanoparticles shown shift between the absorbance and surface plasmon resonance peaks in their UV-Vis spectra, this implies that the optical properties of the colloid nanoparticles depends on laser parameters, this was confirmed with the variation of the band gap energy. Furthermore, red shift for the absorbance peak was observed for samples as-growth at 532 nm around the 150 nm as function of time preparation. Whereas, for the samples as-growth at 1064 nm there is no shift in the absorbance spectra, this can be due to agglomeration and formation of larger particles. The characterization results shown appropriate plasmonic photo-catalysts properties of the particles, hence the photo activation of the nanoparticles was examined on antibacterial effect using colonies of Staphylococcus Aureus and Escherichia coli.
Upregulation of the Intestinal Paracellular Pathway with Breakdown of Tight and Adherens Junctions in Deficit Schizophrenia
Authors: Maes Michael , Sirivichayakul Sunee , Kanchanatawan Buranee , Vodjani Aristo
Published: January 2019

In 2001, the first author of this paper reported that schizophrenia is associated with an increased frequency of the haptoglobin (Hp)-2 gene. The precursor of Hp-2 is zonulin, a molecule that affects intercellular tight junction integrity. Recently, we reported increased plasma IgA/IgM responses to Gram-negative bacteria in deficit schizophrenia indicating leaky gut and gut dysbiosis. The current study was performed to examine the integrity of the paracellular (tight and adherens junctions) and transcellular (cytoskeletal proteins) pathways in deficit versus non-deficit schizophrenia. We measured IgM responses to zonulin, occludin, E-cadherin, talin, actin and vinculin in association with IgA responses to Gram-negative bacteria, CCL-11, IgA responses to tryptophan catabolites (TRYCATs), immune activation and IgM to malondialdehyde (MDA) and NO-cysteinyl in 78 schizophrenia patients and 40 controls. We found that the ratio of IgM to zonulin + occudin / talin + actin + viculin (PARA/TRANS) was significantly greater in deficit than in non-deficit schizophrenia and higher in schizophrenia than controls and was significantly associated with increased IgA responses to Gram-negative bacteria. IgM responses to zonulin were positively associated with schizophrenia (versus controls), while IgM to occludin was significantly associated with deficit schizophrenia (versus non-deficit schizophrenia and controls). A large part of the variance (90.8%) in negative and PHEM (psychosis, hostility, excitation and mannerism) symptoms was explained by PARA/TRANS ratio, IgA to Gram-negative bacteria, IgM to E-cadherin and malondialdehyde (MDA) and memory dysfunctions, while 53.3% of the variance in the latter was explained by PARA/TRANS ratio, IgA to Gram-negative bacteria, CCL-11, TRYCATs and immune activation. The results show an upregulated paracellular pathway with breakdown of the tight and ahherens junctions and increased bacterial translocation in deficit schizophrenia. These dysfunctions in the intestinal paracellular route together with lowered natural IgM, immune activation and production of CCL-11 and TRYCATs contribute to the phenomenology of deficit schizophrenia.
Enhancement of Component Images of Multispectral Data by Denoising with Reference
Authors: Abramov Sergey , Uss Mikhail , Lukin Vladimir , Vozel Benoit , Chehdi Kacem , Egiazarian Karen
Published: January 2019

Multispectral remote sensing data may contain component images which are heavily corrupted by noise and pre-filtering (denoising) procedure is often applied to enhance these component images. To do this, one can use reference images – component images having relatively high quality and which are similar to the image subject to pre-filtering. Here we study the following problems: how to select component images that can be used as references (e.g., for the Sentinel multispectral remote sensing data) and how to perform the actual denoising. We demonstrate that component images of the same resolution as well as component images of a better resolution can be used as references. Examples of denoising of real-life images demonstrate high efficiency of the proposed approach.
PROBIOTIC Bacillus subtilis AND Lactobacillus plantarum IN DIET OF NILE TILAPIA
Authors: Guimarães Mateus Cardoso , Dias Danielle de Carla , Von Atzingen Pereira de Araujo Felipe , Ishikawa Carlos Massatoshi , Tachibana Leonardo
Published: January 2019

The aim of this study was to evaluate the effects of a probiotic, composed of Bacillus subtilis and Lactobacillus plantarum in Nile tilapia fry during the sex reversal phase under stress conditions caused by high stocking density. This experiment was conducted in the Fisheries Institute of São Paulo. The experiment design was completely randomized with four treatments: 1) probiotic added feed, 2) probiotic added to water, 3) probiotic added to feed and water and 4) control diet; with three replicates. The variables analyzed were: final weight, total length, specific growth rate, survival, intestinal microbiology and gene expression of TNF-Î± and HSP-70. The results of the zootechnical performance of growth and gene expression did not show significant differences between treatments in the parameters evaluated (P>0.05). In the intestinal tract of fry raised in water with added probiotic, log10 CFU (7.72 Â± 0.51) count of Bacillus spp. was higher than with other treatments which themselves did not differ significantly. It was concluded that the addition of a probiotic of Bacillus subtilis and Lactobacillus plantarum in the feed or water of Nile tilapia fry during the sex reversal phase did not affect the zootechnical performance of growth or expression the genes studied, but modified the intestinal microbiota.
HÁBITO ALIMENTAR DO BEIJUPIRÁ EM PERNAMBUCO, NORDESTE DO BRASIL
Authors: Hamilton Santiago , Barradas Peregrino Júnior Ronaldo , Carvalho Domingues Ernesto , Hissa Vieira Hazin Fábio , Vaske Júnior Teodoro , Severi William
Published: January 2019

O hábito alimentar do beijupirá, Rachycentron canadum, foi descrito ao longo da costa do Estado de Pernambuco, Nordeste do Brasil. Foram capturados 110 exemplares entre fevereiro/2004 e agosto/2006, com comprimento furcal ou zoológico variando entre 40,0 e 137,0 cm (média e desvio padrão: 85,8Â±18,0 cm) e peso total entre 0,4 e 29,8 kg (7,5Â±4,4 kg). Foi avaliada a importí­¢ncia de cada item alimentar na dieta utilizando o í­­ndice de importí­¢ncia relativa (IIR). Dentre os 110 estômagos analisados (52 fêmeas e 58 machos), 92 (83,6%) com algum item alimentar e 18 (16,4%) vazios. Os peixes ósseos foram os principais itens consumidos na dieta alimentar (IIR = 98,7%), entre os quais a mariquita (Holocentrus adscensionis) e o baiacu (Diodon sp.) foram as presas mais consumidas (IIR = 30,7% e 8,2%, respectivamente). A dieta foi composta, ainda, por elasmobrí­¢nquios, crustáceos e cefalópodes (IIR <1% cada). Não foram encontradas diferenças na dieta entre os sexos e classes de tamanho (< ou â"°¥ 69,8 cm de comprimento furcal, L50 estimado para a espécie). Os dados analisados demonstram que, na costa de Pernambuco, o beijupirá é um predador carní­­voro com preferência por peixes ósseos demersais, independente do tamanho e sexo dos indiví­­duos analisados.
HELMINTHIC ENDOFAUNA OF FOUR SPECIES OF FISH FROM LOWER JARI RIVER, A TRIBUTARY OF THE AMAZON BASIN IN BRAZIL
Authors: Sidney Brito Oliveira Marcos , Lima Corrêa Lincoln , Tavares-Dias Marcos
Published: January 2019

Studies on parasites of wild fish populations are important for knowledge of biodiversity, since parasites represent a great fraction of the planet's biodiversity. The present study investigated the helminths fauna of Leporinus friderici, Mylossoma duriventre, Hoplerythrinus unitaeniatus and Osteoglossum bicirrhosum collected from the lower Jari River, in the state of Amapá in the eastern Amazon region, Brazil. These fish, which have varying eating habits, were caught using gill nets with different mesh sizes for analysis of helminths, using standard methodologies. The helminths collected from these hosts were: Procamallanus (Spirocamallnus) inopinatus, Guyanema seriei seriei, Contracaecum sp., Eustrongylides sp. (Nematoda), Clinostomum marginatum, Dadaytrema oxycephala, Caballerotrema aruanense, Posthodiplostomum sp. (Digenea), Quadrigyrus nickoli and Neoechinorhynchus sp. (Acanthocephala). Hoplerythrinus unitaeniatus presented the highest prevalence, intensity and mean abundance of C. marginatum, while M. duriventre was the host with lowest level of this parasite. The greatest diversity was of Contracaecum sp., sole helminth found in all species of fish studied. The presence of larvae of endoparasites indicates that these fish are intermediate hosts in the Jari River basin.
STRUCTURE OF THE FISH ASSEMBLAGE AND FUNCTIONAL GUILDS IN THE ESTUARY OF MARACAÍPE, NORTHEAST COAST OF BRAZIL
Authors: De Lima Toledo Favero Fernanda , Da Silva Araujo Isabela Maria , Severi William
Published: January 2019

The assemblage and functional structure of the fish fauna of the Maracaí­­pe River, municipality of Ipojuca - PE, was characterized by monthly beach trawls carried out from March of 2012 to February of 2013. A beach trawl net (picaré) was used at three different points of the estuary (EST 1, EST 2 and EST 3) during day and night trawls. The captured specimens were measured and weighed in the laboratory, identified and separated into use and trophic guilds using appropriate literature. Abiotic variables (temperature, salinity, dissolved oxygen, pH, turbidity and chlorophyll-a) were analyzed as for differences between day periods (night and day) and seasons (dry and rainy), and correlated to fish abundance. No difference was detected between day periods (p>0.07 for all variables), but they differed between seasons for most variables (pâ"°¤0.02), and between sampling points only for dissolved oxygen (p=0.03). In one year of collection, 11,513 specimens were captured, belonging to 92 species, 38 families and 15 orders. Gerreidae, Atherinopsidae, Clupeidae, Gobiidae and Hemiramphidae were responsible for 82.9% of the total abundance. The estuary of the Maracaí­­pe River presents a rich ichthyofauna, but with the quantitative predominance of seven species (Atherinella brasiliensis, Eucinostomus argenteus, E. melanopterus, Ulaema lefroyi, Lile piquitinga, Ctenogobius boleosoma and Hyporhamphus unifasciatus). In the estuary, six species classified as vulnerable on the IUCN Endangered Species List were reported. The estuary presents a high diversity of species, most of them marine, carnivorous, and opportunistic, showing the high resilience of this environment. The predominance of juvenile fish underscores the importance of the Maracaí­­pe River estuary for the maintenance of population stocks of coastal species, demonstrating the urgent demand of management of this environment.
SALTED SARDINE RESIDUE TO FEED COBIA: ZOOTECHNIC ADVANTAGES AND HISTOLOGICAL RESPONSES
Authors: Amaral Herrera Leandro , Gomes Sanches Eduardo , Yuri Sato Luciana , Moron Machado Thaís , Villanova Kuhnen Vanessa , Shimada Borges João
Published: January 2019

Industrial fish processing generates a significant amount of wastes, which are high-value nutritional by product. Therefore, the use of fish residues could be a sustainable practice for fattening marine finfishes. In the present study, we have evaluated the benefits of feeding cobia juveniles with three different diets based on residues of salted sardine: (i) formulated with acid silage of salted sardine residue; (ii) formulated with salted residue combined with an acidity regulator; and (iii) pure salted sardine residue. Fishes that were feed with pure salted sardine residue had significant body weight gain and also expressed a lower feed conversion rate. Fishes feed with the other two diets presented a similarly lower zootechnic performance. Also, no significant changes indicating a harmful effect of salted sardine residue for cobia feed were observed in the digestive tract of any the fishes. However, the diet based only on salted sardine residue showed higher organosomatic indexes. That can be attributed to the rich lipid and fatty acid contents of pure residue and it can be an indicative that silage processing was unable to provide the same amount of fatty acids, as pure residue diet did. In conclusion, our results indicate that pure salted sardine residue was the best choice of feed for the cobia. The use of salted sardine residue as diet complementation should be further evaluated, since its use can improve aquaculture development as an instrument of fishery resources conservation.
TEACHER EMPOWERMENT IN APPLYING LEARNING PRINCIPLES TO DEAF STUDENTS IN ELEMENTARY SCHOOL, SUKAMAKMUR DISTRICT
Authors: Winarsih Murni , Bintoro Totok
Published: January 2019

ABSTRACT

 The purpose of this community service activity is to provide knowledge and skills to elementary school teachers in applying the principles of learning for deaf students in inclusive education institutions. Insights into the knowledge and skills provided about the basic concepts of inclusive education, the introduction of ABK and its characteristics, identification of deaf ABK, the principles of deaf ABK learning and assessment of learning outcomes for deaf ABK. This activity was carried out in the form of Technical Guidance (Bimtek) for elementary school teachers. The topic was the Socialization of Children with Special Needs specifically Deafness in the Fostered area of Sukamakmur District, Bogor. This community service is carried out for 2 (two) days through training methods, lectures, interactive discussions, Q and A with speakers coming from lecturers of Special Education (PKh) study programs. This P2M activity was followed enthusiastically by 50 teachers from schools located in Sukamakmur District. The results obtained from this P2M activity are changes in the mindset of teachers in looking at ABK and addressing inclusive education. In addition, teachers also have skills in identifying deaf ABK and learning by using specific principles for deaf ABK. It is expected that this P2M activity can be continued in the following year with more diverse material and wider target groups.

 

 

ABSTRAK

Tujuan kegiatan pengabdian kepada masyarakat ini adalah untuk memberikan bekal pengetahuan dan keterampilan kepada guru sekolah dasar dalam menerapkan prinsip-prinsip pembelajaran untuk siswa tunarungu yang berada di sekolah penyelengagara pendidikan inklusif. Wawasan pengetahuan dan keterampilan yang diberikan tentang konsep dasar pendidikan inklusif, pengenalan ABK dan karakteristiknya, identifikasi ABK tunarungu, prinsip-prinsip pembelajaran ABK tunarungu dan penilaian hasil belajar bagi ABK tunarungu. Kegiatan ini dilakukan dalam bentuk Bimbingan Teknis (Bimtek) untuk guru sekolah dasar tentang Sosialisasi Anak Berkebutuhan Khusus Tunarungu Di Gugus Wilayah Binaan Kecamatan Sukamakmur Bogor. Pengabdian masyarakat ini dilaksanakan selama 2 (dua) hari dengan metode pelatihan, melalui ceramah, diskusi dan tanya jawab interaktif, dengan nara sumber yaitu dosen-dosen program studi Pendidikan Khusus (PKh). Kegiatan P2M ini diikuti dengan antusias dan penuh semangat oleh 50 orang guru yang berasal dari sekolah-sekolah yang berada di Kecamatan Sukamakmur. Hasil yang diperoleh dari kegiatan P2M ini adalah perubahan mindset para guru dalam memandang ABK dan menyikapi pendidikan inklusif. Selain itu guru-guru juga memiliki keterampilan dalam mengidentifikasi ABK tunarungu serta melakukan pembelajaran dengan menggunakan prinsip-prisip khusus bagi ABK tunarungu. Diharapkan kegiatan P2M ini dapat dilanjutkan pada tahun berikutnya dengan materi yang lebih beragam dan kelompok sasaran yang lebih luas lagi.
Workshop Pemanfaatan Rumput Laut Untuk Pembuatan Ice Gel Bagi Masyarakat Pulau Tidung, Kab. Kepulauan Seribu, Prov. DKI Jakarta
Authors: Lubis Johansyah , Masyhur Mustofa , Nurfitranto Nurfitranto
Published: January 2019

Abstrak ,

Pengabdian Kepada Masyarakat ini bertujuan membantu dan mensosialisasikan pemanfaatan rumput laut untuk dibuat ice gel, dimana kebutuhan akan ice gel, saat ini semakin besar, karena digunakan untuk proses recovery anak yang sedang sakit, proses recovery, atau untuk kepentingan ekonomi, pembuatan ice gel dapat dilakukan dengan berbagai cara salah satu sumbernya adalah dengan rumput laut (algae), dimasyarakat Pulau Tidung yang merupakan salah satu daerah penghasil rumput laut, masih belum optimal pemanfaatannya, petani lebih senang menjual hasil panennya kepada tengkulak, PkM ini dengan metode workshop, dimana Target luaran yang diharapkan setelah pelaksanaan workshop ini adalah meningkatkan kemampuan masyarakat pulau Tidung tentang pengetahuan dasar  algae serta kemampuan pemanfaatan rumput laut menjadi ice gel yang akan dimanfaatkan untuk proses recovery. Pada pelaksanaannya semua peserta antusias mengikuti dengan baik dan mendapat dukungan dari pemerintah setempat bahkan dari Pemerintah Kabupaten.

Abstract,

This community service program was aimed to help the community bycommunicating the utilization of algae to produce ice gel of which need recently grows greatly as it is commonly used in the recovery process of an ill child, recovery process in general, or for an economical purpose. To produce ice gel, any material can be used. Algae is one of them. The PulauTidung community as one of the algae farmers is seen not to have utilized the algae optimally. They prefer to sell their harvest to the middlemen. The objective of this program with workshop as its method was to increase the awareness of PulauTidung community of basic knowledge about algae and help them acquire the competence in utilizing algae to produce ice gel which then could be used in recovery process. During workshop, all participants seem to be enthusiastic in following all activities and they received support from both local and regency governments.
Study of Nutritional Profile of Elderly Males of Rural Area Belonging to Different Income Groups
Authors: Kaur Prabhjot
Published: January 2019

Micronutrients deficiency are often common in elderly people due to a number of factors like reduced food intake and lack of variety in foods they eat. To study the food habits, food pattern, dietary intake and their effect upon nutritional profile of elderly males belonging to rural and urban area. This was a cross sectional study done among 100 elderly males, 50 each belonging to HIG and LIG in various villages of district Ludhiana in the age group of 60 and above. A pretested, semi- structured questionnaire was used to collect the data. The data was analyzed by using different statistics formulas. The result shows that the average daily intake of energy by the elderly male respondents of HIG ranged from 1565 kcal to 1818 kcal and for respondents of LIG ranged from 1432 kcal to1660 kcal which was below the energy requirements given for 60+ age group based on their body weights. Significant association was found between knowledge and occupation, education, marital status and income. This study shows that the diet of the respondents of HIG were adequate in protein, fat, calcium, iron, vitamin C but were inadequate in energy, carbohydrates, fibre, carotene and riboflavin. The diets of elderly of LIG respondents were inadequate in all the major nutrients leading to nutritional deficiencies and making them more susceptible to diseases.
Reflexiones sobre la abogacía después del genocidio: a cuarenta años de la “noche de las corbatas”
Authors: Price Jorge Eduardo Douglas
Published: January 2019

O trabalho se desenvolve a partir de um fato pontual, mas de grande poder simbólico, sucedido durante a última ditadura militar argentina (1976-1983), sobre o papel do direito e dos advogados, com base em distinções tais como estado de direito e estado de exceção, seguindo a categoria proposta por Agamben. Destaca que a inversão da fórmula de Clausewitz (a guerra é a continuação da política por outros meios), desloca a lógica jurídica legal/ilegal, para substituí-la pela lógica da guerra, de amigo/inimigo, na qual o que desaparece é o próprio conceito de cidadão, deixando os corpos, a nuda vita, à disposição dos “guardiães”, com o propósito de disciplinar a sociedade. O episódio conhecido como a “noite das gravatas”, quando um grupo de advogados trabalhistas é sequestrado, torturado, alguns deles mortos e os outros desaparecidos, evidencia como o exercício consciente da advocacia implica, para a lógica do estado de exceção, uma intolerável irritação que é preciso eliminar. Conclui refletindo sobre o papel da memória, o da advocacia e, a partir do ensaio de Ricoeur, sobre a possibilidade de impedir que Auschwitz, ou algo análogo ao estado de exceção, possam retornar.
Os miseráveis da lei: uma análise da desigualdade social no sistema punitivo brasileiro a partir do romance “Os miseráveis” de Victor Hugo
Authors: Lacerda Thiago Barbosa , Melo Arquimedes Fernandes Monteiro de
Published: January 2019

Os miseráveis é uma obra grandiosa não pelo longo texto, mas principalmente por conseguir tratar de forma tão simples o complexo debate acerca do ideal de justiça. Através da saga de Jean Valjean, condenado à prisão por roubar um pão, Victor Hugo desnuda toda a crueldade da sociedade francesa do século XIX, denunciando sua extrema desigualdade social e seu sistema judiciário tendencioso. O autor alerta que a obra seria necessária enquanto situações semelhantes às narradas no livro perdurassem. Quase duzentos anos depois, no Brasil do século XXI, há semelhança surpreendente com a realidade francesa: mulheres e homens miseráveis, levados à criminalidade pela extrema pobreza e recebendo a punição desproporcional de um sistema judiciário seletivo. Assim, o objetivo do artigo é traçar os paralelos entre o tempo e espaço de Os miseráveis e a realidade brasileira, por meio de uma análise da prática punitiva vigente. Utilizando-se da revisão de bibliografia, tanto do Direito quanto de áreas correlatas, além de estudos estatísticos do Brasil contemporâneo, busca-se traçar paralelos entre as duas realidades. Esse estudo demonstra de forma assustadora a atualidade da obra de Victor Hugo, quando analisada à luz dos dados coletados, demonstrando a premente necessidade de explorá-la.
Barbárie e exceção: o desvelamento do paradigma da atuação do direito pela literatura de testemunho de Primo Levi
Authors: Félix Diogo Valério
Published: January 2019

O presente trabalho tem por finalidade apresentar um debate sobre o paradoxo do estado de exceção, como estrutura de significação do direito de governança, em uma aproximação entre o direito e a literatura pelo método dedutivo, tendo a fonte de investigação teórica apoio na pesquisa bibliográfica. Para tanto, a análise se inicia com o relato de Primo Levi, um literato italiano sobrevivente de Auschwitz, no sentido de demonstrar em que medida a literatura de testemunho ilustra a existência e a condição do campo de concentração e de seu vivente como uma situação normativamente paradoxal, capaz de proporcionar, inclusive, a destruição completa das subjetividades humanas. Dentro dessa perspectiva, acompanhando a leitura de Giorgio Agamben, o artigo apresenta uma genealogia do direito com supedâneo no instituto do “bando”, em contraposição à teoria do contrato social, enquanto matriz teórica e paradigma do Direito. Assim o campo de concentração, na forma da exceção, revela-se em uma estrutura originária na qual o direito se refere à vida, e a inclui em si através de sua própria suspensão, fazendo por concluir que o “campo”, de forma espectral, é o resultado da operação do direito e da política via dispositivo de captura.
Na sala da execução – o último ato do drama dos exploradores de cavernas?
Authors: Michel Voltaire De Freitas , Deitos Marc Antoni
Published: January 2019

O artigo apresenta uma fantasia especulativa, a partir do problema filosófico proposto por Lon L. Fuller, em 1949, em sua obra O caso dos exploradores de cavernas. Desde o fato narrado pelo autor, a morte de um dos exploradores por seus companheiros presos numa caverna, o texto original retrata a simulação de um julgamento num cenário distópico e futuro, no ano de 4300, no hipotético país Newgarth. Nesse trabalho, a proposta é prosseguir com a discussão, colocando a decisão sobre a efetiva condenação dos exploradores nas mãos e mentes dos seus carrascos – os personagens fictícios Tomás, Helmut e Ronaldo. Com a discussão entre os carrascos, sobre se devem ou não cumprir a decisão do tribunal, novas indagações surgem sobre o papel institucional do Poder Judiciário e a natureza e finalidade do direito. A metodologia empregada é ficcional, a partir do texto-base original de Lon L. Fuller; o texto original é complementado com uma investigação sobre como teria sido a discussão entre os responsáveis pelo cumprimento da ordem final.
“Antígona” de Sófocles e a questão jurídica fundamental: a eterna tensão entre segurança jurídica e correção
Authors: Wiviurka Eduardo Seino
Published: January 2019

A Antígona de Sófocles possui um lugar de destaque na Filosofia do Direito. Essa tragédia expressa dilemas jurídicos e oferece símbolos que comportam múltiplas interpretações. Através dos séculos a obra foi lida, majoritariamente, a partir de um viés dualista em que pretensões de justiça antagônicas de Antígona e Creonte se chocam – a satisfação de um ponto de vista implica a destruição do outro. Entretanto, François Ost ofereceu uma nova interpretação à tensão proposta por Sófocles, encontrando um terceiro momento em que a conciliação entre os opostos é possível. Tal momento seria ocupado pela função jurisdicional em que o hermeneuta buscaria a melhor conciliação entre as partes litigantes. Esta pesquisa, após discutir um panorama geral de Antígona e detalhar a contribuição de Ost, vai além de Ost e argumenta a partir de nomes de destaque na Filosofia do Direito contemporânea (a saber, Habermas, Alexy e Dworkin) como que a tensão presente em Antígona é análoga estruturalmente a questões jurídicas enfrentadas ao longo da história.
Utopía, literatura y derecho
Authors: Avila Santamaría Ramiro
Published: January 2019

O mundo está passando por múltiplas crises e precisamos transformar nossa realidade. Mas o que é a realidade e como transformá-la? O artigo começa questionando a concepção tradicional de realidade e assume que aquilo que pode ser alcançado é representar o mundo à nossa volta, e essa representação será sempre provisória e sujeita a mudanças. Uma das maneiras de mudar a representação é através da ação simbólica. Se percepções, pensamentos e valores mudam, então a realidade é alterada. Transformar a realidade exige ter um projeto de vida que seja possível e viável e que leve a algo melhor, o que pode ser chamado de utopia. Mas a utopia requer imaginação. A melhor maneira de alimentar a imaginação e, portanto, visualizar outros mundos possíveis, é através da arte em geral e da literatura em particular. O direito tem desempenhado papel importante na criação e sustentação do mundo como o conhecemos. Se o mundo tem que se transformar, o mesmo deve acontecer com o direito. Daí a necessidade de olhar, criticar e criar um direito carregado de imaginação e de utopia, e de recorrer à literatura como meio para alcançá-lo.
Narrativa y género: sobre desigualdad y justicia social en “Villette” de C. Brontë e “Insolación” de E. Pardo Bazán
Authors: Monereo Atienza Cristina
Published: January 2019

Neste trabalho se analisam duas obras literárias que retornam às origens do movimento feminista e concebem uma crítica à sociedade patriarcal, a divisão de papeis e à concepção marginalizada da mulher nesse momento. São ambos textos críticos que representam a um indivíduo isolado e indefeso em uma sociedade dominada pelo pensamento e a beneficência da igreja; refletem uma sociedade naturalmente organizada na qual se oculta ou invisibilizam às desigualdade de gênero, disfarçadas como pura e simples questão de diferença de/entre sexos; uma sociedade onde se idealizam umas supostas características femininas (a beleza, a delicadeza, a sensibilidade) sob as que se esconde a autêntica dominação do sexo masculino; inclusive, nas que domina o mito da incompreensão e o mistério que despertam as mulheres como uma forma de submissão à racionalidade masculina. Ante tal situação, se provoca à mulher para levantar sua voz diferenciada, plantando a semente para criar um novo sujeito com liberdade para gerar projetos de vida digna independentemente do sexo. No âmbito público se estabelecem às bases para a reconstrução de uma sociedade que não separe artificialmente entre a esfera pública e privada, e na que predomine uma nova teoria da justiça baseada mais na pluralidade e diferença de expectativas, necessidades e bens.
A “poética da visão” de J. Saramago: algumas questões para pensar a hermenêutica jurídica
Authors: Karam Henriete
Published: January 2019

Este artigo tem como objetivo confrontar e refletir sobre distintas matrizes epistemológicas, a partir da poética da visão identificada nas produções literárias de José Saramago, bem como de elementos figurativos e temáticos extraídos do romance Ensaio sobre a cegueira. Explicitando as dimensões do olhar, do ver e do reparar, busca-se problematizar a adoção, no campo do direito, de postulados que vinculam a tarefa hermenêutica, com exclusividade, tanto à racionalidade e à objetividade quanto à subjetividade do intérprete.
O Controle sobre os Espaços (Patrimonialização, Privatização e Monopolização): o Caso das Ondas de Surfe
Authors: Guibert Christophe
Published: January 2019

Neste artigo, as ondas do litoral costeiro são consideradas “materialidades naturais” que adquirem visibilidade principalmente através da sua qualidade para a prática do surfe. As ondas constituem um bom meio para identificar diferentes processos de apropriação. Considerando os territórios e suas configurações espaciais, assim como as vontades dos praticantes e/ou as formas de regulação política, três processos de apropriação de ondas são identificados, cada um levando a diferentes resultados, sejam de ordem política, econômica, sejam “identitária”. Em primeiro lugar, as ondas de surfe podem ser patrimonializadas a fim de identificação territorial (principal caso analisado aqui). Elas também podem ser pura e simplesmente privatizadas, a fim de alcançar lucros estritamente econômicos. Finalmente, elas podem ser mais ou menos monopolizadas, a fim de manter uma comunidade fechada em si mesma. Essas três formas de apropriação, constituídas a partir de casos analisados em diferentes pesquisas de campo, permitem insistir no fato de que os processos de apropriação de um objeto homogêneo como a onda podem trazer resultados completamente diferentes.Palavras-chave: Ondas de surfe. Processos de apropriação. Patrimonialização. Privatização. Monopolização
Em que mundo vivemos? Notas sobre o reparto do trabalho e dos recursos em nosso planeta
Authors: Vitória Paulo Renato
Published: January 2019

Este ensaio tem o objetivo de apresentar, através de uma metodologia relacional, alguns dados e reflexões sobre como estão distribuídos, de um modo geral, o trabalho e os recursos a nível mundial na atualidade. A partir deste relato parcial e situado, abordo a relação entre a globalização neoliberal e as classificações derivadas das heterarquias raciais/étnicas globais construídas pela modernidade/colonialidade ocidental. Está dividido em três partes: na primeira, questiono o social-conformismo predominante, chamando atenção ao fato de que todos os “diferentes mundos” necessariamente convivem em um mesmo mundo objetivo; na segunda, apresento alguns dados sobre como este mundo está organizado; e na terceira, reflito sobre este retrato em diálogo com o pensamento decolonial latino-americano e com as epistemologias do sul. Palavras-chave: Globalização. Desigualdades. Colonialidade. Ciências sociais.
Como as democracias morrem: um livro assustadoramente familiar
Authors: Barbosa Saulo Vinicius Souza
Published: January 2019

Resenha do Livro "Como as Democracias Morrem"
O Serviço Social Embasado em Direitos como Ferramenta para a Realização dos Direitos Humanos das Crianças Migrantes Venezuelanas nos Países da América Latina
Authors: Delfini Capistrano de Oliveira Ana Cláudia , Da Luz Scherf Erick
Published: January 2019

Se os fluxos migratórios contemporâneos no Sul Global são frequentemente negligenciados, os desafios decorrentes da migração infantil constituem um “gueto dentro de outro gueto” nos estudos da migração transnacional no Sul, embora o cenário de crescente migração internacional na América Latina tenha testemunhado uma virada desde a eclosão da crise venezuelana em 2013. A estimativa é de que cerca de 2,3 milhões de pessoas tenham deixado o país desde de 2014, com crianças ocupando uma porcentagem importante destes deslocamentos humanos. Este artigo explora como a prática do serviço social embasado em direitos com crianças migrantes venezuelanas pode ajudá-las a superar posições de vulnerabilidade e privação de direitos. O método que adotamos é o indutivo, com a pesquisa bibliográfica servindo como principal mecanismo de busca.Palavras-chave: Serviço Social. Direitos Humanos. Migração Infantil. Crianças Venezuelanas. América Latina.
Domain-Specific Stabilization of Structural and Dynamic Responses of Human Serum Albumin by Sucrose
Authors: Mohan Vaisakh , Sengupta Bhaswati , Das Nilimesh , Banerjee Indrani , Sen Pratik
Published: January 2019

Background:

Human Serum Albumin (HSA) is the most abundant protein present in human blood plasma. It is a large multi-domain protein with 585 amino acid residues. Due to its importance in human body, studies on the interaction of HSA with different external agent is of vital interest. The denaturation and renaturation of HSA in presence of external agents are of particular interest as they affect the biological activity of the protein.

Objective:

The objective of this work is to study the domain-specific and overall structural and dynamical changes occurring to HSA in the presence of a denaturing agent, urea and a renaturing agent, sucrose.

Methods:

In order to carry out the domain-specific studies, HSA has been tagged using N-(7- dimethylamino-4-methylcoumarin-3-yl) iodoacetamide (DACIA) at Cys-34 of domain-I and pnitrophenyl coumarin ester (NPCE) at Tyr-411 site in domain-III, separately. Steady-state absorption, emission and solvation dynamic measurements have been carried out in order to monitor the domain-specific alteration of HSA caused by the external agents. The overall structural change of HSA have been monitored using circular dichroism spectroscopy.

Results:

The α-helicity of HSA was found to decrease from 65% to 11% in presence of urea and was found to further increase to 25% when sucrose is added, manifesting the denaturing and renaturing effects of urea and sucrose, respectively. The steady state studies show that domain-III is more labile towards denaturation as compared to domain-I. The presence of an intermediate state is observed during the denaturation process. The stabilization of this intermediate state in presence of sucrose is attributed as the reason for the stabilization of HSA by sucrose. From solvation dynamics studies, it could be seen that the solvation time of DACIA inside domain-I of HSA decreases and increases regularly with increasing concentrations of urea and sucrose, respectively, while in the case of NPCE-tagged domain-III, the effect of sucrose on solvation time is evident only at high concentrations of urea.

Conclusion:

The denaturing and renaturing effects of urea and sucrose could be clearly seen from the steady state studies and circular dichroism spectroscopy measurements. A regular change in solvation time could only be observed in the case of domain-I and not in domain-III. The results indicate that the renaturing effect of sucrose on domain-III is not very evident when protein is in its native state, but is evident in when the protein is denatured.
A Case Analysis on CT Guided Percutaneous Lung Puncture Biopsy of Lymphocyte Mesenchymal Pneumonia
Authors: Zhu Dan , Yu Long , Chen Hui
Published: January 2019

Objective: To explore the application and diagnostic value of high-resolution CT in the
process of lymphocytic interstitial pneumonia clinical diagnosis, and analyze one case of CT-guided
percutaneous lung biopsy lymphocytic interstitial pneumonia.

Methods:

The medical record of a patient with lymphocyte interstitial pneumonia (LIP) who came to
the clinic on 2014-04-22 were analyzed and summarized retrospectively.

Results:

The patient was a 55 years old female farmer. The CT-guided percutaneous lung biopsy was
performed at her first visit; on 2014-07-09, the patient returned to our outpatient clinic with the main
complaint of "1 week of coughing and blood in sputum and phlegm". Pathology consultation report
from the PLA General Hospital on 2014-07-29 showed: (right lower lung) pneumonic pseudo-tumor;
Zhejiang First Hospital’s pathology consultation report on 2014-08-11 showed: lymphocyte
interstitial pneumonia.

Conclusion:

The diagnosis of lymphocyte interstitial pneumonia (LIP) with high-resolution CT may
be used to increase its clinical diagnosis rate, reduce misdiagnosis and improve early detection.
Drug-Induced Peripheral Neuropathy: A Narrative Review
Authors: Jones Mark R. , Urits Ivan , Wolf John , Corrigan Devin , Colburn Luc , Peterson Emily , Williamson Amber , Viswanath Omar
Published: January 2019

Background:

Peripheral neuropathy is a painful condition deriving from many and varied
etiologies. Certain medications have been implicated in the iatrogenic development of Drug
Induced Peripheral Neuropathy (DIPN) and include chemotherapeutic agents, antimicrobials, cardiovascular
drugs, psychotropic, anticonvulsants, among others. This review synthesizes current
clinical concepts regarding the mechanism, common inciting medications, and treatment options for
drug-induced peripheral neuropathy.

Methods:

The authors undertook a structured search of bibliographic databases for peer-reviewed
research literature using a focused review question and inclusion/exclusion criteria. The most relevant
and up to date research was included.

Results:

Drug-induced peripheral neuropathy is a common and painful condition caused by many
different and frequently prescribed medications. Most often, DIPN is seen in chemotherapeutic
agents, antimicrobials, cardiovascular drugs, psychotropic, and anticonvulsant drugs. Certain drugs
exhibit more consistent neuropathic side effects, such as the chemotherapeutic compounds, but
others are more commonly prescribed by a larger proportion of providers, such as the statins. DIPN
is more likely to occur in patients with concomitant risk factors such as preexisting neuropathy,
diabetes, and associated genetically predisposing diseases. DIPN is often difficult to treat, however
medications including duloxetine, and gabapentin are shown to reduce neuropathic pain. Advanced
techniques of neuromodulation offer promise though further randomized and controlled studies are
needed to confirm efficacy.

Conclusion:

Awareness of the drugs covered in this review and their potential for adverse neuropathic
effect is important for providers caring for patients who report new onset symptoms of pain,
paresthesia, or weakness. Prevention of DIPN is especially important because treatment often
proves challenging. While many pharmacologic therapies have demonstrated analgesic potential in
the pain caused by DIPN, many patients remain refractive to treatment. More studies are needed to
elucidate the effectiveness of interventional, neuromodulating therapies.
Adverse Drug Reactions to Radiographic Contrast Media in a Teaching Hospital in North India: An Observational Study
Authors: Chopra Deepti , Jain Abhinav , Garg Richa , Dhingra Shreya
Published: January 2019

Background:

Radiocontrast media are used extensively nowadays to visualize internal organs.
Currently, non-ionic iodinated contrast media are used which are generally considered to be safe
but some adverse reactions have been reported. Thus, the present study was carried out to analyze the
nature and incidence of adverse drug reactions (ADRs) to radiographic contrast media in a teaching
hospital.

Methods:

An observational study carried out for a period of six months in a teaching hospital. Contrast
media induced adverse reactions were analyzed in terms of affected organs, rate, causality assessment,
severity and preventability. The treatment and outcomes of adverse events were also recorded. Naranjo
Probability Scale was used to evaluate the relationship between the contrast agent used and the suspected
ADR. The severity of the suspected ADRs was determined using Hartwig Scale and preventability
was assessed using modified Schumock and Thornton criterion.

Results:

A total of 15 suspected ADRs occurred in 11 patients with an incidence of 1.4%. It included 5
(45.4%) males and 6 (54.5%) females (p < 05). The highest percentage (72.7 %) of ADRs was seen in
adult patients, the mean age being 40.8 years. Vomiting (33.3%) was the most common ADR noted
followed by severe nausea and rashes. 64.7 % of ADRs were categorized as probable and 35.3 % were
possible. Adverse reactions required treatment in 46.6% patients. There was no fatality reported.

Conclusion:

The reactions observed were mild to moderate in severity and occurred within 30 minutes
of the administration of the contrast.
Synthesis of New N1Arylpiperazine Substituted Xanthine Derivatives and Evaluation of their Antioxidant and Cytotoxic Effects
Authors: Andonova Lily , Valkova Iva , Zheleva-Dimitrova Dimitrina , Georgieva Maya , Momekov Georgi , Zlatkov Alexander
Published: January 2019

Background:

Cancer is one of the leading causes of morbidity and mortality worldwide, with approximately
14 million new cases in 2012, with most of the clinically used drugs being ineffective.
Methylxanthines have raised more interest in research on modifying their structure because of their diverse
biological activity. In addition, the piperazine nucleus is one of the most important heterocycles exhibiting remarkable
pharmacological activities.

Methods:

The structure of the obtained compounds was characterized and elucidated by IR, 1H and 13C NMR
and LCMS spectral analysis. The purity of the substances was proven by corresponding melting points and
elemental analysis. The antioxidant activity was evaluated by four common methods – DPPH, ABTS, FRAP and
lipid peroxidation assay. The cytotoxic effects of the tested series were evaluated using the standard MTT-dye
reduction assay on three tumour cell lines.

Results:

A series of new xanthine derivatives comprising an arylpiperazine moiety at N1 were synthesized. The
cytotoxicity against human T-cell leukemia cell SKW-3, human acute myeloid leukemia HL-60 and human Bcell
precursor leukemia cell REH was evaluated. The relationship between the structure and citotoxicity of the
compounds was investigated by quantitative structure-activity relationship (QSAR) analysis and the important
structural parameters were drawn.

Conclusion:

The highest antioxidant activity was demonstrated by compound 6c. The highest cytotoxic effect
was observed for compound 6f. It was found that cytotoxicity against SKW-3 depends on the electron density
distribution in the structures. Branching of the molecular skeleton and introduction of heteroatoms like fluorine
and sulfur in the structures also significantly improved the antiproliferative activity of the compounds.