bluuebunny/crossref_metadata_2025 huggingface dataset:
Perspective Transformer and MobileNets-Based 3D Lane Detection from Single 2D Image
Authors: Li Mengyu , Chu Phuong Minh , Cho Kyungeun
Published: October 2022

Three-dimensional (3D) lane detection is widely used in image understanding, image analysis, 3D scene reconstruction, and autonomous driving. Recently, various methods for 3D lane detection from single two-dimensional (2D) images have been proposed to address inaccurate lane layouts in scenarios (e.g., uphill, downhill, and bumps). Many previous studies struggled in solving complex cases involving realistic datasets. In addition, these methods have low accuracy and high computational resource requirements. To solve these problems, we put forward a high-quality method to predict 3D lanes from a single 2D image captured by conventional cameras, which is also cost effective. The proposed method comprises the following three stages. First, a MobileNet model that requires low computational resources was employed to generate multiscale front-view features from a single RGB image. Then, a perspective transformer calculated bird’s eye view (BEV) features from the front-view features. Finally, two convolutional neural networks were used for predicting the 2D and 3D coordinates and respective lane types. The results of the high-reliability experiments verified that our method achieves fast convergence and provides high-quality 3D lanes from single 2D images. Moreover, the proposed method requires no exceptional computational resources, thereby reducing its implementation costs.
Mg-Ni-Nb2O5 Composite Produced by High-Pressure Torsion
Authors: Fibela-Esparza Martin , Salinas-Rodriguez Armando , Méndez-Nonell Juan , Herrera-Ramirez José Martin , Todaka Yoshikazu , Cabañas-Moreno José Gerardo
Published: October 2022

A Mg-based composite material has been produced by the consolidation at room temperature of a Mg-5wt.% Ni-2wt.% Nb2O5 powder mixture subjected to high-pressure torsion (HPT), one of the processing methods to induce severe plastic deformations. The microstructure, density, and microhardness of the consolidated disks were characterized after the application of up to 30 revolutions in torsion under compression stresses of 3 and 5 GPa. According to the density measurements, the composite was consolidated in full after the application of five revolutions, although disks subjected to only one revolution exhibited densities close to the maximum measured value. On the other hand, grain size and microhardness measurements showed that differences existed at locations near the center and the periphery of the HPT-processed disks. Under the stress of 5 GPa, the grain size in the central regions stabilized at about 0.35 μm after five revolutions, while at the peripherical regions it gradually decreased with an increasing number of revolutions down to about 0.15 μm after 30 revolutions. In turn, the microhardness measured along a diametral cross section steadily increased with the number of revolutions between 1 and 10 revolutions, maintaining a gradient from the center to the periphery in all cases. With the application of 20 and 30 revolutions, only the peripheral regions increased considerably in hardness. It was discovered that the magnesium particles in the initial powder mixture had formed an oxide—hydroxide surface layer, which changed the expected final density of the consolidated material by about 2 to 4.5%. This superficial contamination of the Mg powders did not prevent the material from achieving full consolidation.
Wear-Resistant Fe6AlCoCrNi Medium-Entropy Alloy Coating Made by Laser Cladding
Authors: Chen Ke , Pan Hongbo , Wu Mingyu , Wang Xianfa , Li Dongyang
Published: October 2022

An Fe6AlCoCrNi medium-entropy (MEA) coating was coated on a steel substrate by laser cladding. The micro-structure, crystal structure, phases, and wear properties of the coating were investigated. The coating was mainly composed of a dendritic face-center cubic (FCC) phase, which showed preferred crystal orientation of <2 0 0>, normal to the coating surface, and a body-center cubic (BCC) phase. The MEA coating exhibited satisfactory rigidity with superior wear resistance at different loads and temperatures, much higher than that of the steel substrate. When the test temperature increased from 293 K to 573 K, the coefficient of friction (COF) of the coating markedly decreased from about 0.75 to 0.35; a large decrease in wear was also observed. The wear mechanism of the MEA coating was abrasion wear at room temperature, while the wear of the coating at high temperatures involved considerable oxidation, which enhanced the wear resistance of the coating.
Study on the Root Causes and Prevention of Coating Cracks in the Cargo Hold of a Product Carrier
Authors: Yi Myung-Su , Seo Kwang-Cheol , Park Joo-Shin
Published: October 2022

Recently, shipyards have been booming in the product carrier (PC) market of the global shipbuilding industry. Due to the rising market conditions, orders for large container vessels and PCs are also steadily increasing. According to the industry, freight rates for LR tankers (70K) and MR tankers (50K) in the shipbuilding industry have rose to the highest level during the previous year. In order to secure the competitiveness of PCs, various core items are required, and Korean shipbuilders have been leading the market for a long time based on their knowledge of the design and production of low-fuel ships. In recent years, there have been frequent cases of coating cracks in the cargo hold after sea trial. All relevant rules presented by the classification so far are structural design, safety evaluation, and inspection standards, and coating cracks are considered a problem for coating makers. In other words, they must establish a standard coating measure agreed upon by all parties (owner, shipbuilder, and coating maker); therefore, solutions have been proposed by each shipping company. In this study, the causes of coating cracks occurring in the cargo hold of PCs during tank tests in sea trials were analyzed and measures to prevent them were studied. The main point of this study is assumed that coating crack are caused by mechanical load induced by structural behavior, and the numerical analysis methodology is newly introduced. Based on the results of the numerical analysis, it was confirmed that there is a high probability of coating cracks in the critical area where high stress occurs in the cargo hold. Therefore, the results obtained in this study will be useful to prevent coating cracks in future PC designs.
Effect of Couple Stress and Mass Transpiration on Ternary Hybrid Nanoliquid over a Stretching/Shrinking Sheet with Heat Transfer
Authors: Sneha Kolkar Nanjappa , Vanitha Gadabanahalli Puttasiddappa , Mahabaleshwar Ulavathi Shettar , Laroze David
Published: October 2022

The present article describes the unsteady flow of a couple stress via a ternary hybrid nanofluid on a stretching surface with porous media. The nanofluid exhibits important properties for increasing heat transmission, and it is widely used in manufacturing and industrial applications. The basic similarity equations have been discovered to accommodate both stretching/shrinking surfaces. Ternary hybrid nanofluid is a colloidal combination of three types of microspheres: Al2O3, single wall carbon nanotubes, and graphene. For investigating spherical, cylindrical, and platelet nanoparticles, the governing partial differential equations are converted into ordinary differential equations, expending appropriate transformations. The analytical solution can then be carried out using various forms of nanoparticles, such as spherical, cylindrical, and platelet, to obtain the solution domain. Heat transfer is used in an electrically conducting fluid and also including thermal radiation, as calculated with the Biot number. The focus of the present effort is the evaluation of the flow of ternary hybrid nanofluid over a porous media via thermal radiation, with couple stress, using an analytical process. For various physical parameters, the velocity and temperature conditions are shown graphically.
High-Speed Shift Register with Dual-Gated Thin-Film Transistors for a 31-Inch 4K AMOLED Display
Authors: Song Rong , Wu Yonghe , Lin Chengkai , Liu Kai , Qing Zhenjun , Li Yingxiang , Xue Yan
Published: October 2022

In this work, a promising dual-gated thin film transistor (TFT) structure has been proposed and introduced in the shift register (SR)-integrated circuits to reduce the rising time. The threshold voltage can be simultaneously changed by the top gate and the bottom gate in the proposed dual-gated TFTs. When the SR circuits start to export the scan signals in the displays, the driving currents in the SR circuits are increased by switching the working station of driving TFTs from the enhancement characterization to the depletion characterization. Subsequently, the detailed smart spice simulation has been used to study the function of the proposed SR circuits. In the next step, the proposed SR circuits have been fabricated in a G4.5 active-matrix organic light-emitting diode manufacture factory. The simulated and experimental results indicate that the shift register pulses with the full swing amplitude can be obtained in the SR circuits. Moreover, in contrast to the conventional SR circuits employing with the single-gated TFTs, it has been found that the rising time of the output signals can be reduced from 3.75 μs to 1.23 μs in the proposed SR circuits with the dual-gated TFTs, thus exhibiting the significant improvement of the driving force in the proposed SR circuits. Finally, we demonstrated a 31-inch 4K AMOLED display with the proposed SR circuits.
Development of Pressure Sensor Based Wearable Pulse Detection Device for Radial Pulse Monitoring
Authors: Wang Shihang , Zhang Zhinan , Chen Zhijian , Mei Deqing , Wang Yancheng
Published: October 2022

Wearable pulse detection devices can be used for daily human healthcare monitoring; however, the relatively poor flexibility and low sensitivity of the pulse detection devices are hindering the scrutiny of pulse information during pulse diagnosis of different pulse positions. This paper developed a novel and wearable pulse detection device based on three flexible pressure sensors using synthetic graphene and silver composites as the pressure sensing material. The structural design of the pulse detection device is firstly presented; the core component of pressure sensors is using the sawtooth protrusions to convert pressure induced by radial pulse vibrations into localized deformation of graphene composites. The fabricated pulse detection device is characterized by high pressure sensing performance, including relatively high sensitivity (8.65% kPa−1), broad sensing range (12 kPa), and good dynamic response with a response time of about 100 ms. Then, the pulse detection device is worn on a human wrist to detect the pulses from three pulse positions, namely, ‘Cun’, ‘Guan’, and ‘Chi’, and the results demonstrated the capability of using our device to detect pulse signals. The physical conditions of the subject, such as arterial stiffness index, can be further analyzed through the characteristics of the acquired pulse signals, demonstrating the potential application of using wearable pulse detection devices for human health monitoring.
Reservoir Computing-Based Design of ZnO Memristor-Type Digital Identification Circuits
Authors: Wang Lixun , Zhang Yuejun , Guo Zhecheng , Wu Zhixin , Chen Xinhui , Du Shimin
Published: October 2022

Reservoir Computing (RC) is a network architecture inspired by biological neural systems that maps time-dimensional input features to a high-dimensional space for computation. The key to hardware implementation of the RC system is whether sufficient reservoir states can be generated. In this paper, a laboratory-prepared zinc oxide (ZnO) memristor is reported and modeled. The device is found to have nonlinear dynamic responses and characteristics of simulating neurosynaptic long-term potentiation (LTP) and long-term depression (LTD). Based on this, a novel two-level RC structure based on the ZnO memristor is proposed. Novel synaptic encoding is used to maintain stress activity based on the characteristics of after-discharge and proneness to fatigue during synaptic transmission. This greatly alleviates the limitations of the self-attenuating characteristic reservoir of the duration and interval of the input signal. This makes the reservoir, in combination with a fully connected neural network, an ideal system for time series classification. The experimental results show that the recognition rate for the complete MNIST dataset is 95.08% when 35 neurons are present as hidden layers while achieving low training consumption.
Enhanced Visualisation of Normal Anatomy with Potential Use of Augmented Reality Superimposed on Three-Dimensional Printed Models
Authors: Geerlings-Batt Jade , Tillett Carley , Gupta Ashu , Sun Zhonghua
Published: October 2022

Anatomical knowledge underpins the practice of many healthcare professions. While cadaveric specimens are generally used to demonstrate realistic anatomy, high cost, ethical considerations and limited accessibility can often impede their suitability for use as teaching tools. This study aimed to develop an alternative to traditional teaching methods; a novel teaching tool using augmented reality (AR) and three-dimensional (3D) printed models to accurately demonstrate normal ankle and foot anatomy. An open-source software (3D Slicer) was used to segment a high-resolution magnetic resonance imaging (MRI) dataset of a healthy volunteer ankle and produce virtual bone and musculature objects. Bone and musculature were segmented using seed-planting and interpolation functions, respectively. Virtual models were imported into Unity 3D, which was used to develop user interface and achieve interactability prior to export to the Microsoft HoloLens 2. Three life-size models of bony anatomy were printed in yellow polylactic acid and thermoplastic polyurethane, with another model printed in white Visijet SL Flex with a supporting base attached to its plantar aspect. Interactive user interface with functional toggle switches was developed. Object recognition did not function as intended, with adequate tracking and AR superimposition not achieved. The models accurately demonstrate bony foot and ankle anatomy in relation to the associated musculature. Although segmentation outcomes were sufficient, the process was highly time consuming, with effective object recognition tools relatively inaccessible. This may limit the reproducibility of augmented reality learning tools on a larger scale. Research is required to determine the extent to which this tool accurately demonstrates anatomy and ascertain whether use of this tool improves learning outcomes and is effective for teaching anatomy.
Seasonal Effect on Bacterial Communities Associated with the Rhizospheres of Polhillia, Wiborgia and Wiborgiella Species in the Cape Fynbos, South Africa
Authors: Mpai Tiisetso , Jaiswal Sanjay K. , Cupido Christopher N. , Dakora Felix D.
Published: October 2022

The Cape fynbos biome in South Africa is home to highly diverse and endemic shrub legumes, which include species of Aspalathus, Polhillia, Wiborgia and Wiborgiella. These species play a significant role in improving soil fertility due to their ability to fix N2. However, information regarding their microbiome is still unknown. Using the 16S rRNA Miseq illumina sequencing, this study assessed the bacterial community structure associated with the rhizospheres of Polhillia pallens, Polhillia brevicalyx, Wiborgia obcordata, Wiborgia sericea and Wiborgiella sessilifolia growing at different locations during the wet and dry seasons in the Cape fynbos. The results showed that the most dominant bacterial phylum was Actinobacteria during both the dry (56.2–37.2%) and wet (46.3–33.3%) seasons. Unclassified bacterial genera (19.9–27.7%) were the largest inhabitants in the rhizospheres of all five species during the two seasons. The other dominant phyla included Bacteroidetes, Acidobacteria, Proteobacteria and Firmicutes. Mycobacterium and Conexibacter genera were the biggest populations found in the rhizosphere soil of all five test species during both seasons, except for W. obcordata soil sampled during the dry season, which had Dehalogenimonas as the major inhabitant (6.08%). In this study plant species and growth season were the major drivers of microbial community structure, with W. obcordata having the greatest influence on its microbiome than the other test species. The wet season promoted greater microbial diversity than the dry season.
Graphene Oxide Exhibits Antifungal Activity against Bipolaris sorokiniana In Vitro and In Vivo
Authors: Zhang Xiao , Cao Huifen , Wang Juan , Li Feng , Zhao Jianguo
Published: October 2022

The antimicrobial properties of graphene in vitro have been widely reported. However, compared to research performed on graphene’s antibacterial properties, there have been relatively few studies assessing graphene’s antifungal properties. In particular, evaluating graphene’s pathogenic effects on host plants in vivo, which is critical to using graphene in disease control, has rarely been performed. In this study, the fungal pathogen of wheat, barley, and other plants, Bipolaris sorokiniana (B. sorokiniana) and graphene oxide (GO) were selected for materials. A combination of physiological, cytological, and biochemical approaches was used to explore how GO affects the growth and pathogenicity of B. sorokiniana. The mycelial growth and spore germination of B. sorokiniana were both inhibited in a dose-dependent manner by GO treatment. The addition of GO significantly alleviated the infection of pathogenic fungi in host plants. The results of scanning electron microscopy demonstrated that the inhibitory effect of GO on B. sorokiniana was primarily related to the destruction of the cell membrane. Our study confirmed the antifungal effect of graphene in vitro and in vivo, providing an experimental basis for applying graphene in disease resistance, which is of great significance for agricultural and forestry production.
Importance of Microbiome of Fecal Samples Obtained from Adolescents with Different Weight Conditions on Resistance Gene Transfer
Authors: Navarro Armando , Rodea Gerardo E. , Castelán-Sánchez Hugo G. , Saucedo-Pastrana Héctor Armando , Licona-Moreno Delia , Eslava-Campos Carlos , Tirado-Gómez Laura L. , Vilchis-Reyes Ariel , García de la Torre Guadalupe , Cruz-Licea Verónica
Published: October 2022

Antimicrobial resistance (AMR) is a relevant public health problem worldwide, and microbiome bacteria may contribute to the horizontal gene transfer associated with antimicrobial resistance. The microbiome of fecal samples from Mexican adolescents were analyzed and correlated with eating habits, and the presence of AMR genes on bacteria in the microbiome was evaluated. Fecal samples from adolescents were collected and processed to extract genomic DNA. An Illumina HiSeq 1500 system was used to determine resistance genes and the microbiome of adolescents through the amplification of gene resistance and the V3–V4 regions of RNA, respectively. Analysis of the microbiome from fecal samples taken from 18 obese, overweight, and normal-weight adolescents revealed that the Firmicutes was the most frequent phylum, followed by Bacteroidetes, Actinobacteria, Proteobacteria and Verrucomicrobia. The following species were detected as the most frequent in the samples: F. prausnitzii, P. cori, B. adolescentis, E. coli and A. muciniphila. The presence of Bacteroides, Prevotella and Ruminococcus was used to establish the enterotype; enterotype 1 was more common in women and enterotype 2 was more common in men. Twenty-nine AMR genes were found for β-lactamases, fluoroquinolones, aminoglycosides, macrolide, lincosamides, streptogramin (MLS), tetracyclines and sulfonamides. The presence of microorganisms in fecal samples that harbor AMR genes that work against antimicrobials frequently used for the treatment of microbial infections such as b-lactams, macrolides, aminoglycosides, MLS, and tetracyclines is of great concern, as these organisms may be an important reservoir for horizontal AMR gene transfer.
View from the Top: Insights into the Diversity and Community Assembly of Ectomycorrhizal and Saprotrophic Fungi along an Altitudinal Gradient in Chinese Boreal Larix gmelinii-Dominated Forests
Authors: Guo Yi , Ji Li , Wang Mingwei , Shan Chengfeng , Shen Fangyuan , Yang Yuchun , He Gongxiu , Purahong Witoon , Yang Lixue
Published: October 2022

The altitudinal patterns of soil fungi have attracted considerable attention; however, few studies have investigated the diversity and community assembly of fungal functional guilds along an altitudinal gradient. Here, we explored ectomycorrhizal (EcM) and saprotrophic (SAP) fungal diversity and community assembly along a 470 m vertical gradient (ranging from 830 to 1300 m) on Oakley Mountain, sampling bulk soils in the 0–10 cm and 10–20 cm soil layers of Larix gmelinii-dominated forests. Illumina MiSeq sequencing of the ITS genes was employed to explore the fungal community composition and diversity. The relative abundance of EcM and SAP fungi showed a divergent pattern along an altitudinal gradient, while we observed a consistent altitudinal tendency for EcM and SAP fungal diversity and community assembly. The diversity of both fungal guilds increased with increasing altitude. Altitude and soil moisture were the key factors affecting the community composition of both fungal guilds. In addition, the plant community composition significantly affected the EcM fungal community composition, whereas the dissolved organic nitrogen and ammonium nitrogen contents were the driving factors of SAP fungal community. Despite the effects of vegetation and soil factors, EcM and SAP fungal communities were mainly governed by stochastic processes (especially drift) at different altitudes and soil depths. These results shed new light on the ecology of different fungal functional guilds along an altitudinal gradient, which will provide a deeper understanding of the biogeography of soil fungi.
Nanoenergetic Composites with Fluoropolymers: Transition from Powders to Structures
Authors: Pisharath Sreekumar , Ong Yew Jin , Hng Huey Hoon
Published: October 2022

Over the years, nanoenergetic materials have attracted enormous research interest due to their overall better combustion characteristics compared to their micron-sized counterparts. Aluminum, boron, and their respective alloys are the most extensively studied nanoenergetic materials. The majority of the research work related to this topic is confined to the respective powders. However, for practical applications, the powders need to be consolidated into reactive structures. Processing the nanoenergetic materials with polymeric binders to prepare structured composites is a possible route for the conversion of powders to structures. Most of the binders, including the energetic ones, when mixed with nanoenergetic materials even in small quantities, adversely affects the ignitability and combustion performance of the corresponding composites. The passivating effect induced by the polymeric binder is considered unfavorable for ignitability. Fluoropolymers, with their ability to induce pre-ignition reactions with the nascent oxide shell around aluminum and boron, are recognized to sustain the ignitability of the composites. Initial research efforts have been focused on surface functionalizing approaches using fluoropolymers to activate them further for energy release, and to improve the safety and storage properties. With the combined advent of more advanced chemistry and manufacturing techniques, fluoropolymers are recently being investigated as binders to process nanoenergetic materials to reactive structures. This review focuses on the major research developments in this area that have significantly assisted in the transitioning of nanoenergetic powders to structures using fluoropolymers as binders.
The Influence of the Polymer Type on the Quality of Newly Developed Oral Immediate-Release Tablets Containing Amiodarone Solid Dispersions Obtained by Hot-Melt Extrusion
Authors: Fița Ancuța Cătălina , Secăreanu Ana Andreea , Musuc Adina Magdalena , Ozon Emma Adriana , Sarbu Iulian , Atkinson Irina , Rusu Adriana , Mati Erand , Anuta Valentina , Pop Anca Lucia
Published: October 2022

The present study aims to demonstrate the influence of the polymer-carrier type and proportion on the quality performance of newly developed oral immediate-release tablets containing amiodarone solid dispersions obtained by hot-melt extrusion. Twelve solid dispersions including amiodarone and different polymers (PEG 1500, PEG 4000; PEG 8000, Soluplus®, and Kolliphor® 188) were developed and prepared by hot-melt extrusion using a horizontal extruder realized by the authors in their own laboratory. Only eleven of the dispersions presented suitable physical characteristics and they were used as active ingredients in eleven tablet formulations that contain the same amounts of the same excipients, varying only in solid dispersion type. The solid dispersions’ properties were established by optical microscopy with reflected light, volumetric controls and particle size evaluation. In order to prove that the complex powders have appropriate physical characteristics for the direct compression process, they were subjected to different analyses regarding their flowability and compressibility behavior. Additionally, the Fourier transform infrared spectroscopy and X-ray diffraction analysis were performed on the obtained solid dispersions. After confirming the proper physical attributes for all blends, they were processed into the form of tablets by direct compression technology. The manufactured tablets were evaluated for pharmacotechnical (dimensions–diameter and thickness, mass uniformity, hardness and friability) and in vitro biopharmaceutical (disintegration time and drug release) performances. Furthermore, the influence of the polymer matrix on their quality was determined. The high differences in flow and compression performances of the solid dispersions prove the relevant influence of the polymer type and their concentration-dependent plasticizing properties. The increase in flowability and compressibility characteristics of the solid dispersions could be noticed after combining them with direct compression excipients owning superior mechanical qualities. The influence of the polymer type is best detected in the disintegration test, where the obtained values are quite different between the studied formulations. The use of PEG 1500 alone or combined in various proportions with Soluplus® leads to rapid disintegration. In contrast, the mixture of PEG 4000 and Poloxamer 188 in equal proportions determined the increase in disintegration time to 120 s. The use of Poloxamer 188 alone and a 3:1 combination of PEG 4000 and Soluplus® also generates a prolonged disintegration time for the tablets.
State-of-the-Art Analytical Approaches for Illicit Drug Profiling in Forensic Investigations
Authors: Ahmed Reem , Altamimi Mohamad J. , Hachem Mayssa
Published: October 2022

In forensic chemistry, when investigating seized illicit drugs, the profiling or chemical fingerprinting of drugs is considered fundamental. This involves the identification, quantitation and categorization of drug samples into groups, providing investigative leads such as a common or different origin of seized samples. Further goals of drug profiling include the elucidation of synthetic pathways, identification of adulterants and impurities, as well as identification of a drug’s geographic origin, specifically for plant-derived exhibits. The aim of this state-of-art-review is to present the traditional and advanced analytical approaches commonly followed by forensic chemists worldwide for illicit drug profiling. We discussed numerous methodologies for the physical and chemical profiling of organic and inorganic impurities found in illicit drug. Applications of powerful spectroscopic and chromatographic tools for illicit drug profiling including isotope-Ratio mass spectrometry (IRMS), gas chromatography–mass spectrometry (GC-MS), gas chromatography–isotope ratio mass spectrometry (GC-IRMS), ultra-high-performance liquid chromatography (UHPLC), thin layer chromatography (TLC), liquid chromatography–mass spectrometry (LC-MS) and inductively coupled plasma-mass spectrometry (ICP-MS) were discussed. Altogether, the techniques covered in this paper to profile seized illicit drugs could aid forensic chemists in selecting and applying a suitable method to extract valuable profiling data.
Portable Wireless Intelligent Electrochemical Sensor for the Ultrasensitive Detection of Rutin Using Functionalized Black Phosphorene Nanocomposite
Authors: Shi Fan , Ai Yijing , Wang Baoli , Yao Yucen , Zhang Zejun , Zhou Juan , Wang Xianghui , Sun Wei
Published: October 2022

To build a portable and sensitive method for monitoring the concentration of the flavonoid rutin, a new electrochemical sensing procedure was established. By using nitrogen-doped carbonized polymer dots (N-CPDs) anchoring few-layer black phosphorene (N-CPDs@FLBP) 0D-2D heterostructure and gold nanoparticles (AuNPs) as the modifiers, a carbon ionic liquid electrode and a screen-printed electrode (SPE) were used as the substrate electrodes to construct a conventional electrochemical sensor and a portable wireless intelligent electrochemical sensor, respectively. The electrochemical behavior of rutin on the fabricated electrochemical sensors was explored in detail, with the analytical performances investigated. Due to the electroactive groups of rutin, and the specific π-π stacking and cation–π interaction between the nanocomposite with rutin, the electrochemical responses of rutin were greatly enhanced on the AuNPs/N-CPDs@FLBP-modified electrodes. Under the optimal conditions, ultra-sensitive detection of rutin could be realized on AuNPs/N-CPDs@FLBP/SPE with the detection range of 1.0 nmol L−1 to 220.0 μmol L−1 and the detection limit of 0.33 nmol L−1 (S/N = 3). Finally, two kinds of sensors were applied to test the real samples with satisfactory results.
Qualitative Analysis of Multiple Phytochemical Compounds in Tojapride Based on UHPLC Q-Exactive Orbitrap Mass Spectrometry
Authors: Zhang Liying , Qin Shihan , Tang Sunv , E Shuai , Li Kailin , Li Jing , Cai Wei , Sun Lei , Li Hui
Published: October 2022

Tojapride is composed of Caulis Perillae, Rhizoma Cyperi, Radix Glycyrrhizae, Citrus aurantium L., Coptis chinensis Franch, Pericarpium Citri Reticulatae, Reynoutria japonica Houtt, Tetradium ruticarpum, and Cleistocactus sepium. It has the effects of inhibiting gastric acid and relieving pain. It is clinically used for treating gastroesophageal reflux disease. To further study the pharmacodynamic properties of Tojapride, the systematic characterization of the chemical constituents in Tojapride was investigated using ultra-performance liquid chromatography with Q-Exactive Orbitrap mass spectrometry combined with parallel reaction monitoring for the first time. Eventually, a total of 222 compounds, including flavonoids, alkaloids, and glycyrrhizic acid derivatives, were identified based on the chromatographic retention times, MS/MS2 information, and bibliography data; a total of 218 of these were reported for the first time as being present in Tojapride. This newly developed approach provides a powerful tool for extending our understanding of chemical constituents of Tojapride, which can be further extended to other TCMP composition research.
Optimized Sample Preparation and Microscale Separation Methods for High-Sensitivity Analysis of Hydrophilic Peptides
Authors: Tóth Gábor , Sugár Simon , Balbisi Mirjam , Molnár Balázs András , Bugyi Fanni , Fügedi Kata Dorina , Drahos László , Turiák Lilla
Published: October 2022

The optimization of solid-phase extraction (SPE) purification and chromatographic separation is usually neglected during proteomics studies. However, the effects on detection performance are not negligible, especially when working with highly glycosylated samples. We performed a comparative study of different SPE setups, including an in-house optimized method and reversed-phase chromatographic gradients for the analysis of highly glycosylated plasma fractions as a model sample for glycopeptide analysis. The in-house-developed SPE method outperformed the graphite-based and hydrophilic interaction liquid chromatography (HILIC) purification methods in detection performance, recovery, and repeatability. During optimization of the chromatography, peak distribution was maximized to increase the peptide detection rate. As a result, we present sample purification and chromatographic separation methods optimized for the analysis of hydrophilic samples, the most important of which is heavily N-glycosylated protein mixtures.
Synthesis, Characterization, Biological Evaluation, and In Silico Studies of Imidazolium-, Pyridinium-, and Ammonium-Based Ionic Liquids Containing n-Butyl Side Chains
Authors: Hassan Rabia , Nazir Farzana , Roosh Mah , Qaisar Arshemah , Habib Uzma , Sajini Abdulrahim A. , Iqbal Mudassir
Published: October 2022

Ionic liquids (ILs) have emerged as active pharmaceutical ingredients because of their excellent antibacterial and biological activities. Herein, we used the green-chemistry-synthesis procedure, also known as the metathesis method, to develop three series of ionic liquids using 1-methyl-3-butyl imidazolium, butyl pyridinium, and diethyldibutylammonium as cations, and bromide (Br−), methanesulfonate (CH3SO3−), bis(trifluoromethanesulfonyl)imide (NTf2−), dichloroacetate (CHCl2CO2−), tetrafluoroborate (BF4−), and hydrogen sulfate (HSO4−) as anions. Spectroscopic methods were used to validate the structures of the lab-synthesized ILs. We performed an agar well diffusion assay by using pathogenic bacteria that cause various infections (Escherichia coli; Enterobacter aerogenes; Klebsiella pneumoniae; Proteus vulgaris; Pseudomonas aeruginosa; Streptococcus pneumoniae; Streptococcus pyogenes) to scrutinize the in vitro antibacterial activity of the ILs. It was established that the nature and unique combination of the cations and anions were responsible for the antibacterial activity of the ILs. Among the tested ionic liquids, the imidazolium cation and NTf2− and HSO4− anions exhibited the highest antibacterial activity. The antibacterial potential was further investigated by in silico studies, and it was observed that bis(trifluoromethanesulfonyl)imide (NTf2−) containing imidazolium and pyridinium ionic liquids showed the maximum inhibition against the targeted bacterial strains and could be utilized in antibiotics. These antibacterial activities float the ILs as a promising alternative to the existing antibiotics and antiseptics.
A New 1,3-Benzodioxole Compound from Hypecoum erectum and Its Antioxidant Activity
Authors: Xu Ning , Bao Wenli , Xin Jiletu , Xiao Hua , Yu Jiaqi , Xu Liang
Published: October 2022

The purpose of this study was to identify the chemical components in aerial parts of Hypecoum erectum. A new 1,3-benzodioxole derivative, identified as Hypecoumic acid (1), was isolated, together with the three known compounds: protopine (2), coptisine (3), and cryptopine (4). Their structures were identified based on extensive spectroscopic experiments, including nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectra (HR-ESI-MS), as well as comparison with those reported in the literature. Meanwhile, the in vitro antioxidative activity of all compounds was determined using a DPPH-scavenging assay, and compound 1 (IC50 = 86.3 ± 0.2 μM) was shown to have moderate antioxidative activity.
Effect of Graphene Sheets Embedded Carbon Films on the Fretting Wear Behaviors of Orthodontic Archwire–Bracket Contacts
Authors: Wang Pengfei , Luo Xin , Qin Jiajie , Pan Zonglin , Zhou Kai
Published: October 2022

Carbon films were fabricated on the orthodontic stainless steel archwires by using a custom-designed electron cyclotron resonance (ECR) plasma sputtering deposition system under electron irradiation with the variation of substrate bias voltages from +5 V to +50 V. Graphene sheets embedded carbon (GSEC) films were fabricated at a higher substrate bias voltage. The fretting friction and wear behaviors of the carbon film-coated archwires running against stainless steel brackets were evaluated by a home-built reciprocating sliding tribometer in artificial saliva environment. Stable and low friction coefficients of less than 0.10 were obtained with the increase of the GSEC film thickness and the introduction of the parallel micro-groove texture on the bracket slot surfaces. Particularly, the GSEC film did not wear out on the archwire after sliding against three-row micro-groove textured bracket for 10,000 times fretting tests; not only low friction coefficient (0.05) but also low wear rate (0.11 × 10−6 mm3/Nm) of the GSEC film were achieved. The synergistic effects of the GSEC films deposited on the archwires and the micro-groove textures fabricated on the brackets contribute to the exceptional friction and wear behaviors of the archwire-bracket sliding contacts, suggesting great potential for the clinical orthodontic treatment applications.
RAFT Hydroxylated Polymers as Templates and Ligands for the Synthesis of Fluorescent ZnO Quantum Dots
Authors: San José Leire , García Olga , Quijada-Garrido Isabel , López-González Mar
Published: October 2022

The remarkable photoluminescent properties, biocompatibility, biodegradability, and antibacterial properties of zinc oxide quantum dots (ZnO QDs) coupled with their low cost and nanoscale size guarantee bio-related and technological applications. However, the effect of the polymeric ligand during synthesis has hardly been investigated compared to other less environmentally friendly QDs. Thus, the objective of this work was to focus on the synthesis of fluorescent hybrid ZnO QDs by the sol-gel method using different polymers with hydroxyl groups as templates and ligands to obtain stable particles in different media. For this purpose, well-defined hydroxylated statistical polymers and block copolymers were synthesized using reversible-addition fragmentation chain transfer (RAFT) polymerization to establish the influence of molecular weight, hydrophobic/hydrophilic balance, and polymer architecture on the colloidal and photophysical properties of the synthesized hybrid ZnO QDs. Dynamic light scattering (DLS), TEM, and X-ray diffraction measurements indicated the formation of stable nanoparticles of a few nanometers. A remarkable enhancement in terms of fluorescence was observed when ZnO QDs were synthesized in the presence of the hydroxylated homopolymers and even more so with block copolymers architecture. Organosilanes combined with the hydroxylated polymers were used to improve the colloidal stability of ZnO QDs in aqueous media. These samples exhibited uniform and stable enhanced photoluminescence for nearly five months of being investigated. Among other applications, the hybrid ZnO QDs synthesized in this work exhibit high selectivity to detect Cr6+, Fe2+, or Cu2+ in water.
Recent Progress in Research on Ferromagnetic Rhenium Disulfide
Authors: Ren Hongtao , Xiang Gang
Published: October 2022

Since long-range magnetic ordering was observed in pristine Cr2Ge2Te6 and monolayer CrCl3, two-dimensional (2D) magnetic materials have gradually become an emerging field of interest. However, it is challenging to induce and modulate magnetism in non-magnetic (NM) materials such as rhenium disulfide (ReS2). Theoretical research shows that defects, doping, strain, particular phase, and domain engineering may facilitate the creation of magnetic ordering in the ReS2 system. These predictions have, to a large extent, stimulated experimental efforts in the field. Herein, we summarize the recent progress on ferromagnetism (FM) in ReS2. We compare the proposed methods to introduce and modulate magnetism in ReS2, some of which have made great experimental breakthroughs. Experimentally, only a few ReS2 materials exhibit room-temperature long-range ferromagnetic order. In addition, the superexchange interaction may cause weak ferromagnetic coupling between neighboring trimers. We also present a few potential research directions for the future, and we finally conclude that a deep and thorough understanding of the origin of FM with and without strain is very important for the development of basic research and practical applications.
Recent Advances in Carbon-Based Iron Catalysts for Organic Synthesis
Authors: Wang Fei , Zhu Fuying , Ren Enxiang , Zhu Guofu , Lu Guo-Ping , Lin Yamei
Published: October 2022

Carbon-based iron catalysts combining the advantages of iron and carbon material are efficient and sustainable catalysts for green organic synthesis. The present review summarizes the recent examples of carbon-based iron catalysts for organic reactions, including reduction, oxidation, tandem and other reactions. In addition, the introduction strategies of iron into carbon materials and the structure and activity relationship (SAR) between these catalysts and organic reactions are also highlighted. Moreover, the challenges and opportunities of organic synthesis over carbon-based iron catalysts have also been addressed. This review will stimulate more systematic and in-depth investigations on carbon-based iron catalysts for exploring sustainable organic chemistry.
Influence of NiO ALD Coatings on the Field Emission Characteristic of CNT Arrays
Authors: Chumak Maksim A. , Filatov Leonid A. , Ezhov Ilya S. , Kolosko Anatoly G. , Filippov Sergey V. , Popov Eugeni O. , Maximov Maxim Yu.
Published: October 2022

The paper presents a study of a large-area field emitter based on a composite of vertically aligned carbon nanotubes covered with a continuous and conformal layer of nickel oxide by the atomic layer deposition method. The arrays of carbon nanotubes were grown by direct current plasma-enhanced chemical vapor deposition on a pure Si substrate using a nickel oxide catalyst which was also deposited by atomic layer deposition. The emission characteristics of an array of pure vertically oriented carbon nanotubes with a structure identical in morphology, covered with a layer of thin nickel oxide, are compared using the data from a unique computerized field emission projector. The deposition of an oxide coating favorably affected the emission current fluctuations, reducing them from 40% to 15% for a pristine carbon nanotube and carbon nanotube/nickel oxide, respectively. However, the 7.5 nm nickel oxide layer coating leads to an increase in the turn-on field from 6.2 to 9.7 V/µm.
Ligand Tuning of Localized Surface Plasmon Resonances in Antimony-Doped Tin Oxide Nanocrystals
Authors: Balitskii Olexiy , Mashkov Oleksandr , Barabash Anastasiia , Rehm Viktor , Afify Hany A. , Li Ning , Hammer Maria S. , Brabec Christoph J. , Eigen Andreas , Halik Marcus , Yarema Olesya , Yarema Maksym , Wood Vanessa , Stifter David , Heiss Wolfgang
Published: October 2022

Aliovalent-doped metal oxide nanocrystals exhibiting localized surface plasmons (LSPRs) are applied in systems that require reflection/scattering/absorption in infrared and optical transparency in visible. Indium tin oxide (ITO) is currently leading the field, but indium resources are known to be very restricted. Antimony-doped tin oxide (ATO) is a cheap candidate to substitute the ITO, but it exhibits less advantageous electronic properties and limited control of the LSPRs. To date, LSPR tuning in ATO NCs has been achieved electrochemically and by aliovalent doping, with a significant decrease in doping efficiency with an increasing doping level. Here, we synthesize plasmonic ATO nanocrystals (NCs) via a solvothermal route and demonstrate ligand exchange to tune the LSPR energies. Attachment of ligands acting as Lewis acids and bases results in LSPR peak shifts with a doping efficiency overcoming those by aliovalent doping. Thus, this strategy is of potential interest for plasmon implementations, which are of potential interest for infrared upconversion, smart glazing, heat absorbers, or thermal barriers.
Steam Activation of Acid-Chars for Enhanced Textural Properties and Pharmaceuticals Removal
Authors: Hubetska Tetiana S. , Mestre Ana S. , Kobylinska Natalia G. , Carvalho Ana P.
Published: October 2022

The present work aims to explore steam activation of sisal or glucose-derived acid-chars as an alternative to KOH activation to prepare superactivated carbons, and to assess the adsorption performance of acid-chars and derived activated carbons for pharmaceuticals removal. Acid-chars were prepared from two biomass precursors (sisal and glucose) using various H2SO4 concentrations (13.5 M, 12 M, and 9 M) and further steam-activated at increasing burn-off degrees. Selected materials were tested for the removal of ibuprofen and iopamidol from aqueous solution (kinetic and equilibrium assays) in single-solute conditions. Activated carbons prepared from acid-char carbonized with 13.5 M and 12 M H2SO4 are mainly microporous solids composed of compact rough particles, yielding a maximum surface area and a total pore volume of 1987 m2 g−1 and 0.96 cm3 g−1, respectively. Solid state NMR reveals that steam activation increased the aromaticity degree and amount of C=O functionalities. Steam activation improved the acid-chars adsorption capacity for ibuprofen from 20-65 mg g−1 to higher than 280 mg g−1, leading to fast adsorption kinetics (15–20 min). The maximum adsorption capacities of selected activated samples for ibuprofen and iopamidol were 323 and 1111 mg g−1, respectively.
Dielectric Metalens for Superoscillatory Focusing Based on High-Order Angular Bessel Function
Authors: Li Yu , Fan Xinhao , Huang Yunfeng , Guo Xuyue , Zhou Liang , Li Peng , Zhao Jianlin
Published: October 2022

The phenomenon of optical superoscillation provides an unprecedented way to solve the problem of optical far-field label-free super-resolution imaging. Numerous optical devices that enable superoscillatory focusing were developed based on scalar and vector diffraction theories in the past several years. However, these reported devices are designed according to the half-wave zone method in spatial coordinates. In this paper, we propose a dielectric metalens for superoscillatory focusing based on the diffraction of angular Bessel functional phase modulated vector field, under the inspiration of the tightly autofocusing property of a radially polarized high-order Bessel beam. Based on this kind of metalens with a numerical aperture (NA) of 0.9, the linearly polarized light is converted into a radially polarized one and then focus into a superoscillating focal spot with the size of 0.32λ/NA. This angular spectrum modulation theory involved in this paper provides a different way of designing superoscillatory devices.