bluuebunny/crossref_metadata_2025 huggingface dataset:
Existence of weak solutions to first-order stationary mean-field games with Dirichlet conditions
Authors: Ferreira Rita , Gomes Diogo , Tada Teruo
Published: July 2019

In this paper, we study first-order stationary monotone mean-field games (MFGs) with Dirichlet boundary conditions. Whereas Dirichlet conditions may not be satisfied for Hamilton–Jacobi equations, here we establish the existence of solutions to MFGs that satisfy those conditions. To construct these solutions, we introduce a monotone regularized problem. Applying Schaefer’s fixed-point theorem and using the monotonicity of the MFG, we verify that there exists a unique weak solution to the regularized problem. Finally, we take the limit of the solutions of the regularized problem and, using Minty’s method, we show the existence of weak solutions to the original MFG.
Adenosine interaction with adenosine receptor A2a promotes gastric cancer metastasis by enhancing PI3K–AKT–mTOR signaling
Authors: Shi Linsen , Wu Zhaoying , Miao Ji , Du Shangce , Ai Shichao , Xu En , Feng Min , Song Jun , Guan Wenxian
Published: July 2019

The accumulation of adenosine in the tumor microenvironment is associated with tumor progression in many cancers. However, whether adenosine is involved in gastric cancer (GC) metastasis and progression, and the underlying molecular mechanism, is largely unclear. In this study, we find that GC tissues and cell lines had higher A2aR levels than nontumor gastric tissues and cell lines. A2aR expression correlated positively with TNMstage, and associated with poor outcomes. Adenosine enhanced the expression of the stemness and epithelial–mesenchymal transition-associated genes by binding to A2aR. A2aR expression on GC cells promoted metastasis in vivo. The PI3K-AKT-mTOR signaling pathway was involved in adenosine-stimulated GC cell migration and invasion. Our results indicate that adenosine promotes GC cell invasion and metastasis by interacting with A2aR to enhance PI3K–AKT–mTOR pathway signaling.
Non-native and Invasive Nylanderia Crazy Ants (Hymenoptera: Formicidae) of the World: Integrating Genomics to Enhance Taxonomic Preparedness
Authors: Williams Jason L , Lucky Andrea
Published: July 2019

Invasive species have devastating economic and ecological impacts worldwide, but proactive monitoring programs are rare on the global stage. By definition, tramp ants are associated with disturbance and human-mediated dispersal, making them especially concerning invasive threats. A proactive—rather than reactive—approach to monitoring for, preventing, and managing invasive species depends on taxonomic preparedness, which enables rapid and accurate identification. Emerging tools and technologies, including genomic barcoding and interactive online keys, can aid in species delimitation and diagnosis. However, resolving tramp species’ identities remains the fundamental first step in invasive species management because diagnostic tools cannot be developed and disseminated until species names are stable. Diagnosis of morphologically difficult species requires basic knowledge of species boundaries, biogeography, and phylogenetic relationships. This review comprehensively synthesizes information available for 15 known and five potential tramp ant species in Nylanderia (Emery) (Hymenoptera: Formicidae): a globally distributed genus of over 130 described species, many of which are only diagnosable by subtle morphological characters. Nylanderia records were drawn from published literature, specimen databases, and museum collections to compile known distributions, biology, natural history, and taxonomy for each species. We review existing resources for visualizing known geographic ranges and high-resolution images of ants globally and encourage the use of these types of tools in support of invasive species diagnosis and distribution tracking. Finally, we discuss how taxonomic and life history information can be used synergistically with genomic and digital technology to develop tools for identification of these, and other emerging invasive insect species.
Prognostic Significance of Stromal and Intraepithelial Tumor-Infiltrating Lymphocytes in Small Intestinal Adenocarcinoma
Authors: Jun Sun-Young , Park Eun Su , Lee Jae Jun , Chang Hee-Kyung , Jung Eun Sun , Oh Young-Ha , Hong Seung-Mo
Published: July 2019

Objectives

Assessment of tumor-infiltrating lymphocytes (TILs) may predict the prognosis and therapeutic benefit of immunotherapy in small intestinal adenocarcinoma (SIAC) patients.

Methods

TILs were evaluated in 231 surgically resected SIACs and compared with microsatellite instability (MSI) and clinicopathologic variables. The average number of intraepithelial TILs (iTILs) and the average density of stromal TILs (sTILs) were calculated separately.

Results

High iTIL count (≥2 per high-power field) was associated with MSI-high, whereas high sTIL density (≥20% on ×200 magnification) was not. High iTIL count and high sTIL density were related to distal tumor location, medullary carcinoma, high Crohn-like lymphoid reaction counts, and fewer pancreatic invasions. SIAC patients with high iTIL count or high sTIL density had better survival than those with low values. On multivariate analysis, MSI, high sTIL density, proximal locations, lower N category, and absence of lymphovascular invasions and retroperitoneal seeding were the best independent prognostic predictors.

Conclusions

High sTIL density can be used as a prognostic indicator and high iTIL count may provide a basis for the clinical use of targeted immunotherapy in SIAC patients.
Seventy Years of Tuberculosis Prevention: Efficacy, Effectiveness, Toxicity, Durability, and Duration
Authors: Salazar-Austin Nicole , Dowdy David W , Chaisson Richard E , Golub Jonathan E
Published: July 2019

Tuberculosis (TB) has been a leading infectious cause of death worldwide for much of human history, with 1.6 million deaths estimated in 2017. The Department of Epidemiology at the Johns Hopkins Bloomberg School of Public Health has played an important role in understanding and responding to TB, and it has made particularly substantial contributions to prevention of TB with chemoprophylaxis. TB preventive therapy is highly efficacious in the prevention of TB disease, yet it remains underutilized by TB programs worldwide despite strong evidence to support its use in high-risk groups, such as people living with HIV and household contacts, including those under 5 years of age. We review the evidence for TB preventive therapy and discuss the future of TB prevention.
Impact of Clinic-Based Blood Pressure Approaches on Blood Pressure Measurement
Authors: Juraschek Stephen P , Ishak Anthony , Mukamal Kenneth J , Cohen Marc L , Beach Jennifer L
Published: July 2019

BACKGROUND

Clinic-based blood pressure (BP) is a closely-tracked metric of health care quality, but is prone to inaccuracy and measurement imprecision. Recent guidelines have advocated for automated office blood pressure (AOBP) devices to improve clinic-based BP assessments.

METHODS

Patients from a single hypertension clinic underwent a 3-day evaluation that included a 24-hour ambulatory blood pressure monitoring (ABPM), 2 manual clinic-based BP measurements (over 2 visits), and an unattended AOBP measurement (single visit). All measurements were compared to the average wake-time systolic BP (SBP) and diastolic BP (DBP) from ABPM.

RESULTS

Among 103 patients (mean age 57.3 ± 14.8 years, 51% women, 29% black) the average wake-time SBP was 131.3 ± 12.3 mm Hg and DBP was 78.3 ± 9.2 mm Hg. The average of 2 manual BPs was significantly higher than wake-time ABPM with mean differences of 5.5 mm Hg (P < 0.001) for SBP and 2.7 mm Hg (P = 0.002) for DBP. In contrast, the averages of the last 2 AOBP measurements did not significantly differ from ABPM with mean differences of 1.6 mm Hg (P = 0.21) for SBP and −0.5 mm Hg (P = 0.62) for DBP. The estimated prevalence of SBP ≥ 140 or DBP ≥ 90 mm Hg based on wake-time ABPM was 27.2% vs. 49.5% based on the average of 2 manual measurements (difference 22.3%; P < 0.001) and 31.1% based on the average of the last 2 AOBP measurements (difference 3.9%; P = 0.57).

CONCLUSIONS

A single visit, unattended AOBP more precisely estimated BP and the prevalence of stage 2 and uncontrolled hypertension than even the average of 2 manual clinic visits, supporting guideline recommendations to use AOBP for clinic-based BP measurements.
The Economic Humanities and the History of Financial Advice
Authors: Crosthwaite Paul , Knight Peter , Marsh Nicky
Published: July 2019

This article charts the emerging interdisciplinary field of the Economic Humanities, and highlights a recent research project on the history of US financial advice writing as an example of what this field might look like in practice. We begin by arguing that the Economic Humanities distinguishes itself from the New Economic Criticism that flourished in the 1990s by virtue of a broadened methodological scope, made possible by greater interaction with various economically oriented branches of the social sciences. We then discuss our History of Financial Advice project as one example of what the Economic Humanities might do, highlighting three especially significant moments in the development of this genre of US writing: the decades around the turn of the twentieth century, either side of the Wall Street Crash of 1929, and the era following the emergence of a canonical body of financial theory in the early 1970s. Finally, in a brief conclusion we point to key areas in which the Economic Humanities has potential to do important critical work in the coming years.
Associations of Metrics of Peak Inhalation Exposure and Skin Exposure Indices With Beryllium Sensitization at a Beryllium Manufacturing Facility
Authors: Virji M Abbas , Schuler Christine R , Cox-Ganser Jean , Stanton Marcia L , Kent Michael S , Kreiss Kathleen , Stefaniak Aleksandr B
Published: July 2019

Objectives

Peak beryllium inhalation exposures and exposure to the skin may be relevant for developing beryllium sensitization (BeS). The objective of this study was to identify risk factors associated with BeS to inform the prevention of sensitization, and the development of chronic beryllium disease (CBD).

Methods

In a survey of short-term workers employed at a primary beryllium manufacturing facility between the years 1994–1999, 264 participants completed a questionnaire and were tested for BeS. A range of qualitative and quantitative peak inhalation metrics and skin exposure indices were created using: personal full-shift beryllium exposure measurements, 15 min to 24 h process-specific task and area exposure measurements, glove measurements as indicator of skin exposure, process-upset information gleaned from historical reports, and self-reported information on exposure events. Hierarchical clustering was conducted to systematically group participants based on similarity of patterns of 16 exposure variables. The associations of the exposure metrics with BeS and self-reported skin symptoms (in work areas processing beryllium salts as well as in other work areas) were evaluated using correlation analysis, log-binomial and logistic regression models with splines.

Results

Metrics of peak inhalation exposure, indices of skin exposure, and using material containing beryllium salts were significantly associated with skin symptoms and BeS; skin symptoms were a strong predictor of BeS. However, in this cohort, we could not tease apart the independent effects of skin exposure from inhalation exposure, as these exposures occurred simultaneously and were highly correlated. Hierarchical clustering identified groups of participants with unique patterns of exposure characteristics resulting in different prevalence of BeS and skin symptoms. A cluster with high skin exposure index and use of material containing beryllium salts had the highest prevalence of BeS and self-reported skin symptoms, followed by a cluster with high inhalation and skin exposure index and a very small fraction of jobs in which beryllium salts were used. A cluster with low inhalation and skin exposure and no workers using beryllium salts had no cases of BeS.

Conclusion

Multiple pathways and types of exposure were associated with BeS and may be important for informing BeS prevention. Prevention efforts should focus on controlling airborne beryllium exposures with attention to peaks, use of process characteristics (e.g. the likelihood of upset conditions to design interventions) minimize skin exposure to beryllium particles, and in particular, eliminate skin contact with beryllium salts to interrupt potential exposure pathways for BeS risk.
Mycoheterotrophic Epirixanthes (Polygalaceae) has a typical angiosperm mitogenome but unorthodox plastid genomes
Authors: Petersen G , Darby H , Lam V K Y , Pedersen H Æ , Merckx V S F T , Zervas A , Seberg O , Graham S W
Published: July 2019

Background and Aims

Fully mycoheterotrophic plants derive carbon and other nutrients from root-associated fungi and have lost the ability to photosynthesize. While mycoheterotroph plastomes are often degraded compared with green plants, the effect of this unusual symbiosis on mitochondrial genome evolution is unknown. By providing the first complete organelle genome data from Polygalaceae, one of only three eudicot families that developed mycoheterotrophy, we explore how both organellar genomes evolved after loss of photosynthesis.

Methods

We sequenced and assembled four complete plastid genomes and a mitochondrial genome from species of Polygalaceae, focusing on non-photosynthetic Epirixanthes. We compared these genomes with those of other mycoheterotroph and parasitic plant lineages, and assessed whether organelle genes in Epirixanthes experienced relaxed or intensified selection compared with autotrophic relatives.

Key Results

Plastomes of two species of Epirixanthes have become substantially degraded compared with that of autotrophic Polygala. Although the lack of photosynthesis is presumably homologous in the genus, the surveyed Epirixanthes species have marked differences in terms of plastome size, structural rearrangements, gene content and substitution rates. Remarkably, both apparently replaced a canonical plastid inverted repeat with large directly repeated sequences. The mitogenome of E. elongata incorporated a considerable number of fossilized plastid genes, by intracellular transfer from an ancestor with a less degraded plastome. Both plastid and mitochondrial genes in E. elongata have increased substitution rates, but the plastid genes of E. pallida do not. Despite this, both species have similar selection patterns operating on plastid housekeeping genes.

Conclusions

Plastome evolution largely fits with patterns of gene degradation seen in other heterotrophic plants, but includes highly unusual directly duplicated regions. The causes of rate elevation in the sequenced Epirixanthes mitogenome and of rate differences in plastomes of related mycoheterotrophic species are not currently understood.
Advanced X-ray CT scanning can boost tree ring research for earth system sciences
Authors: Van den Bulcke Jan , Boone Marijn A , Dhaene Jelle , Van Loo Denis , Van Hoorebeke Luc , Boone Matthieu N , Wyffels Francis , Beeckman Hans , Van Acker Joris , De Mil Tom
Published: July 2019

Background and Aims

Tree rings, as archives of the past and biosensors of the present, offer unique opportunities to study influences of the fluctuating environment over decades to centuries. As such, tree-ring-based wood traits are capital input for global vegetation models. To contribute to earth system sciences, however, sufficient spatial coverage is required of detailed individual-based measurements, necessitating large amounts of data. X-ray computed tomography (CT) scanning is one of the few techniques that can deliver such data sets.

Methods

Increment cores of four different temperate tree species were scanned with a state-of-the-art X-ray CT system at resolutions ranging from 60 μm down to 4.5 μm, with an additional scan at a resolution of 0.8 μm of a splinter-sized sample using a second X-ray CT system to highlight the potential of cell-level scanning. Calibration-free densitometry, based on full scanner simulation of a third X-ray CT system, is illustrated on increment cores of a tropical tree species.

Key Results

We show how multiscale scanning offers unprecedented potential for mapping tree rings and wood traits without sample manipulation and with limited operator intervention. Custom-designed sample holders enable simultaneous scanning of multiple increment cores at resolutions sufficient for tree ring analysis and densitometry as well as single core scanning enabling quantitative wood anatomy, thereby approaching the conventional thin section approach. Standardized X-ray CT volumes are, furthermore, ideal input imagery for automated pipelines with neural-based learning for tree ring detection and measurements of wood traits.

Conclusions

Advanced X-ray CT scanning for high-throughput processing of increment cores is within reach, generating pith-to-bark ring width series, density profiles and wood trait data. This would allow contribution to large-scale monitoring and modelling efforts with sufficient global coverage.
Reproductive and genetic consequences of extreme isolation in Salix herbacea L. at the rear edge of its distribution
Authors: Carbognani M , Piotti A , Leonardi S , Pasini L , Spanu I , Vendramin G G , Tomaselli M , Petraglia A
Published: July 2019

Background and Aims

At the rear edge of the distribution of species, extreme isolation and small population size influence the genetic diversity and differentiation of plant populations. This may be particularly true for Arctic-alpine species in mid-latitude mountains, but exactly how peripherality has shaped their genetic and reproductive characteristics is poorly investigated. The present study, focused on Salix herbacea, aims at providing new insights into the causes behind ongoing demographic dynamics and their consequences for peripheral populations of Arctic-alpine species.

Methods

We performed a whole-population, highly detailed sampling of the only two S. herbacea populations in the northern Apennines, comparing their clonal and genetic diversity, sex ratio and spatial genetic structure with a reference population from the Alps. After inspecting ~1800 grid intersections in the three populations, 563 ramets were genotyped at 11 nuclear microsatellite markers (nSSRs). Past demography and mating patterns of Apennine populations were investigated to elucidate the possible causes of altered reproductive dynamics.

Key Results

Apennine populations, which experienced a Holocene bottleneck and are highly differentiated (FST = 0.15), had lower clonal and genetic diversity compared with the alpine population (RMLG = 1 and HE = 0.71), with the smaller population exhibiting the lowest diversity (RMLG = 0.03 and HE = 0.24). An unbalanced sex ratio was found in the larger (63 F:37 M) and the smaller (99 F:1 M) Apennine population. Both were characterized by the presence of extremely large clones (up to 2500 m2), which, however, did not play a dominant role in local reproductive dynamics.

Conclusions

Under conditions of extreme isolation and progressive size reduction, S. herbacea has experienced an alteration of genetic characteristics produced by the prevalence of clonal growth over sexual reproduction. However, our results showed that the larger Apennine population has maintained levels of sexual reproduction enough to counteract a dramatic loss of genetic and clonal diversity.
Validation of a Concussion Screening Battery for Use in Medical Settings: Predicting Centers for Disease Control Concussion Symptoms in Children and Adolescents
Authors: Lecci Len , Williams Mark , Taravath Sasidharan , Frank Harrison G , Dugan Kelly , Page Ryan , Keith Julian
Published: July 2019

Objective

Effective screening for concussion is increasingly important, and medical professionals play a critical role in diagnostic and return-to-play decisions. However, few well-validated measures are available to assist in those decisions. This study aims to determine whether previously validated measures assessing neurocognitive and neurobehavioral abilities can predict Centers for Disease Control (CDC) concussion symptom endorsement in a sample of child or youth athletes.

Method

Participants were 113 individuals, aged 6–17, representing 29 consecutive cases undergoing a post-concussion evaluation by a pediatric neurologist and 84 consecutive cases completing standardized baseline assessments (i.e., not being evaluated as a follow-up to a concussion). All participants completed the same standardized battery of tests comprised of the Connors’ Continuous Performance Test (CPT 3), the Balance Error Scoring System (BESS), and the NIH 4-Meter Gait Test as well as completing a checklist of CDC concussion symptoms.

Results

Regression analyses indicate that the screening battery explained 33% of the variance (d = 1.4) in concussion symptom endorsement, after controlling for age. The neurocognitive test alone (CPT 3) accounts for 21.5% of the variance (d = 1.05) in symptoms after controlling for age, and the neurobehavioral measures (BESS and NIH 4-Meter Gait) then account for an additional 11.5% variance (accounting for 18.6% variance, d = .96, when entered first). These effect sizes are considered large to very large and reflect a marked increase in predictive validity relative to existing measures commonly used in concussion assessments.

Conclusions

A relatively brief screening battery can function in medical settings to predict significant and substantial variability in CDC concussion symptoms in a pediatric sample.
XIII—The Flow of Time in Experience
Authors: Sattig Thomas
Published: July 2019

Our perceptual experiences as of change over time seem to be accompanied by the sense that time flows. The sense of flow is widely regarded as one of the most elusive aspects of temporal experience. In this paper, I develop a novel account of its nature. I give an initial characterization of the sense of flow as the sense that the present changes—in short, as the sense of replacement. Further, I specify the type of account of the sense of replacement to be developed: since the sense that the present changes will be assumed to be grounded in the perceptual representation that the present changes, my focus will be to explain the perceptual representation that the present changes. I develop an account of the synchronic perceptual representation of the present. Finally, I develop an account of the diachronic perceptual representation of the present as changing.
Natal conditions, lifespan and lifetime reproductive success of European blackbirds
Authors: Wysocki Dariusz , Jankowiak Łukasz , Cholewa Marta , Zyskowski Dawid
Published: July 2019

Even though much has been published in recent years on the factors affecting the lifespan and lifetime reproductive success of birds, there are still gaps in our knowledge. Here, we present the results of a long-term study of European blackbirds which examined the effect of natal conditions on lifespan and lifetime reproductive success (expressed by the number of fledglings) of 152 nestlings (72 males and 80 females) ringed in the Stefan Żeromski Park in Szczecin (NW Poland). We have complete information regarding parental age, family brood (first-egg laying date, clutch size, and hatching sequence), bird size, lifetime reproductive success, pair density and weather conditions during the natal year. For males, total fledgling production was the smaller, the later the laying date of the family brood, but increased with mean daily precipitation and pair density in the natal year. In the case of females, we did not find any significant relationships between their lifetime reproductive success and the above parameters. Male lifespan increased with mean daily precipitation and bird density, but only pair density had a positive effect on female lifespan. We suggest that for females, genetic factors could be more important for their reproductive success than for males. In addition, a blackbird’s lifespan depends strongly on environmental factors.
Computational/in silico methods in drug target and lead prediction
Authors: Agamah Francis E , Mazandu Gaston K , Hassan Radia , Bope Christian D , Thomford Nicholas E , Ghansah Anita , Chimusa Emile R
Published: July 2019

Drug-like compounds are most of the time denied approval and use owing to the unexpected clinical side effects and cross-reactivity observed during clinical trials. These unexpected outcomes resulting in significant increase in attrition rate centralizes on the selected drug targets. These targets may be disease candidate proteins or genes, biological pathways, disease-associated microRNAs, disease-related biomarkers, abnormal molecular phenotypes, crucial nodes of biological network or molecular functions. This is generally linked to several factors, including incomplete knowledge on the drug targets and unpredicted pharmacokinetic expressions upon target interaction or off-target effects. A method used to identify targets, especially for polygenic diseases, is essential and constitutes a major bottleneck in drug development with the fundamental stage being the identification and validation of drug targets of interest for further downstream processes. Thus, various computational methods have been developed to complement experimental approaches in drug discovery. Here, we present an overview of various computational methods and tools applied in predicting or validating drug targets and drug-like molecules. We provide an overview on their advantages and compare these methods to identify effective methods which likely lead to optimal results. We also explore major sources of drug failure considering the challenges and opportunities involved. This review might guide researchers on selecting the most efficient approach or technique during the computational drug discovery process.
THETA: a new genotypic approach for predicting HIV-1 CRF02-AG coreceptor usage
Authors: Dimeglio Chloé , Raymond Stéphanie , Jeanne Nicolas , Reynes Christelle , Carcenac Romain , Lefebvre Caroline , Cazabat Michelle , Nicot Florence , Delobel Pierre , Izopet Jacques
Published: July 2019

Motivation

The circulating recombinant form of HIV-1 CRF02-AG is the most frequent non-B subtype in Europe. Anti-HIV therapy and pathophysiological studies on the impact of HIV-1 tropism require genotypic determination of HIV-1 tropism for non-B subtypes. But genotypic approaches based on analysis of the V3 envelope region perform poorly when used to determine the tropism of CRF02-AG. We, therefore, designed an algorithm based on information from the gp120 and gp41 ectodomain that better predicts the tropism of HIV-1 subtype CRF02-AG.

Results

We used a bio-statistical method to identify the genotypic determinants of CRF02-AG coreceptor use. Toulouse HIV Extended Tropism Algorithm (THETA), based on a Least Absolute Shrinkage and Selection Operator method, uses HIV envelope sequence from phenotypically characterized clones. Prediction of R5X4/X4 viruses was 86% sensitive and that of R5 viruses was 89% specific with our model. The overall accuracy of THETA was 88%, making it sufficiently reliable for predicting the tropism of subtype CRF02-AG sequences.

Availability and implementation

Binaries are freely available for download at https://github.com/viro-tls/THETA. It was implemented in Matlab and supported on MS Windows platform. The sequence data used in this work are available from GenBank under the accession numbers MK618182-MK618417.
Bi-parental mucus provisioning in the scale-eating cichlid Perissodus microlepis (Cichlidae)
Authors: Satoh Shun , Awata Satoshi , Tanaka Hirokazu , Jordan Lyndon A , Kakuda Umi , Hori Michio , Kohda Masanori
Published: July 2019

Although parental care is known to occur in a wide range of teleost fishes, postnatal provisioning of nutrition has been documented rarely. Here, we describe a novel example of bi-parental care in a teleost, i.e. mucus-provisioning behaviour in the scale-eating cichlid Perissodus microlepis endemic to Lake Tanganyika. Field observations revealed that young guarded by their parents frequently glanced towards the body surface of both parents. Furthermore, analyses of stomach contents of the young found the presence of ingested mucus, confirming that the young feed on the mucus secretions of their parents. The frequency of glancing behaviour increased with size of the young up to ~13 mm in standard length, but then declined with further growth. Additionally, the frequency of glancing of young towards their parents was higher when the frequency of foraging on plankton was lower. Underwater cage experiments revealed a higher rate of growth in the young kept in direct contact with their parents than in those not allowed direct contact. We conclude that glancing behaviour in young P. microlepis is a form of direct parental nourishment that confers growth benefits to the young when food abundance is low.
Thrush anvils are calcium source hotspots for many bird species
Authors: Kwieciński Zbigniew , Rosin Zuzanna M , Jankowiak Łukasz , Sparks Tim H , Tryjanowski Piotr
Published: July 2019

Calcium is one of the most important elements determining reproductive success in birds, and snail shells are a well-known source of calcium for egg-laying females. In Europe, song thrushes, Turdus philomelos, break snails open at locations called anvils, eat the soft parts and leave the broken shells. Based on observational studies in 2011–2017 in western Poland, we showed that thrush anvils were visited by 54 other bird species (mainly smaller species) that collected the broken shell fragments. The frequency of visits to anvils differed among species and changed over the course of the breeding season, but anvils were especially used by females during the pre-laying period. Our study is the first description of such widespread exploitation of thrush anvils by other bird species, and we think that this phenomenon has been overlooked owing to the difficulties in recording anvils located, for example, on single small stones, stumps of felled trees and man-made objects such as glass bottles. We conclude that thrush anvils can be an important source of calcium for many bird species that adapt behaviourally to use these places. Hence, anvils should be recognized as localized hotspots for bird diversity.
The Poverty-Aware Paradigm for Child Protection: A Critical Framework for Policy and Practice
Authors: Saar-Heiman Yuval , Gupta Anna
Published: July 2019

This article aims to present a Poverty-Aware Paradigm for Child Protection (PAPCP). The increasing scholarly recognition of the damaging impact of poverty, inequality and the neoliberal politics of ‘risk’ on child protection policy and practice, has highlighted the need for a justice-based and poverty-aware analytical framework for child protection social work. In order to create such a framework, we build upon Krumer-Nevo’s Poverty-Aware Paradigm (PAP)—that was first presented in a previous issue of the British Journal of Social Work—and adapt its paradigmatic premises to the context of child protection social work. By addressing ontological, epistemological and axiological questions underpinning the construction of risk and the practices utilised to deal with it, the article provides a clear, practical and applicable link between critical theories and everyday child protection practice. The PAPCP is presented against the background of the risk-focused paradigm currently dominating the child protection systems in both the authors’ countries—Israel and England.
A Sensitive and Quantitative Isotope-Dilution LC-MS/MS Method for Analysis of Hydrazine in Tobacco Smoke
Authors: Sharifi Mehran , Donisa Carmen , Joza Peter
Published: July 2019

A new isotope dilution liquid chromatography/tandem mass spectrometric method was developed for the analysis of potential hydrazine present in tobacco smoke. The sample preparation was performed via an optimized derivatization method using an aqueous buffer:methanol solution of 2-nitrobenzaldehyde (10 g/L) used as a derivatizing agent. The mainstream smoke of cigarettes was passed through a glass fiber filter pad followed by a trapping solution containing an isotopically labeled 15N2-hydrazine used as internal standard. After smoking, the filter pad was extracted with the trapping solution and then incubated for 30 minutes at 35°C. An aliquot of the extract was centrifuged and the resultant hydrazone was quantified by liquid chromatography tandem mass spectrometry (LC-MS/MS). The isotope dilution standard calibration curve demonstrated good linearity (R2 > 0.999) from 0.079 to 248 ng/mL, with limits of quantification in mainstream smoke of 0.2 and 0.4 ng/cig for ISO and Canadian Intense smoking regimens, respectively. The method recovery was assessed using samples spiked with solutions of known amounts of hydrazine. The results showed good accuracy with recoveries ranging from 98 to 111%. Although there were no detectable levels of hydrazine in the reference cigarettes used in the validation (KR3R4F), the method precision was estimated to be ~10% based on the variability observed in the spiked samples. Trapping efficiencies were assessed using a hydrazine permeation tube providing a known amount of hydrazine vapor such that the distribution between the vapor phase and particulate phase of mainstream smoke could be determined.
Effect of an Intervention Package and Teamwork Training to Prevent Healthcare Personnel Self-contamination During Personal Protective Equipment Doffing
Authors: Andonian Jennifer , Kazi Sadaf , Therkorn Jennifer , Benishek Lauren , Billman Carrie , Schiffhauer Margaret , Nowakowski Elaine , Osei Patience , Gurses Ayse P , Hsu Yea-Jen , Drewry David , Forsyth Ellen R , Vignesh Arjun , Oresanwo Ifeoluwa , Garibaldi Brian T , Rainwater-Lovett Kaitlin , Trexler Polly , Maragakis Lisa L
Published: July 2019

Background

More than 28 000 people were infected with Ebola virus during the 2014–2015 West African outbreak, resulting in more than 11 000 deaths. Better methods are needed to reduce the risk of self-contamination while doffing personal protective equipment (PPE) to prevent pathogen transmission.

Methods

A set of interventions based on previously identified failure modes was designed to mitigate the risk of self- contamination during PPE doffing. These interventions were tested in a randomized controlled trial of 48 participants with no prior experience doffing enhanced PPE. Contamination was simulated using a fluorescent tracer slurry and fluorescent polystyrene latex spheres (PLSs). Self-contamination of scrubs and skin was measured using ultraviolet light visualization and swabbing followed by microscopy, respectively. Doffing sessions were videotaped and reviewed to score standardized teamwork behaviors.

Results

Participants in the intervention group contaminated significantly fewer body sites than those in the control group (median [interquartile range], 6 [3–8] vs 11 [6–13], P = .002). The median contamination score was lower for the intervention group than the control group when measured by ultraviolet light visualization (23.15 vs 64.45, P = .004) and PLS swabbing (72.4 vs 144.8, P = .001). The mean teamwork score was greater in the intervention group (42.2 vs 27.5, P < .001).

Conclusions

An intervention package addressing the PPE doffing task, tools, environment, and teamwork skills significantly reduced the amount of self-contamination by study participants. These elements can be incorporated into PPE guidance and training to reduce the risk of pathogen transmission.
Factors Influencing the Incubation of an Infectious Form of Creutzfeldt-Jakob Disease
Authors: Peckeu Laurène , Brandel Jean-Philippe , Welaratne Arlette , Amar Elodie , Costagliola Dominique , Haïk Stéphane
Published: July 2019

The French epidemics of iatrogenic Creutzfeldt-Jakob disease after growth hormone (GH) treatment provide an opportunity to understand factors governing the inter-human transmission of prions. The present analysis relying on truncated Weibull distribution supports a relationship between host genetics, dose of the at-risk GH, age at treatment onset, and duration of the incubation period.
Clinical Features, Epidemiology, and Climatic Impact of Genotype-specific Human Metapneumovirus Infections: Long-term Surveillance of Hospitalized Patients in South Korea
Authors: Lim Yong Kwan , Kweon Oh Joo , Kim Hye Ryoun , Kim Tae-Hyoung , Lee Mi-Kyung
Published: July 2019

Background

Human metapneumovirus (hMPV) commonly causes upper and lower respiratory tract infections. Here, we performed long-term retrospective surveillance of hMPV infection among patients hospitalized in South Korea between 2007 and 2016 and investigated seasonal dynamics and clinical characteristics associated with each virus subtype/genotype.

Methods

Patient specimens were tested for hMPV and other respiratory viruses by commercial molecular assays. Medical records of hMPV-positive patients were reviewed, and hMPV subtype/genotype analysis was performed. We also collected meteorological data and analyzed relationships with hMPV activity.

Results

Of 23 694 specimens, 1275 (5.4%) were positive; among them, 94.0% were classified into 5 subtypes (A1, A2a, A2b, B1, and B2). Some clinical manifestations differed according to hMPV genotype; however, there was no correlation between hMPV subtype and clinical outcome. Viral activity peaked at 13–20 weeks (April and May) and was associated with climate-specific factors, including temperature, relative humidity, diurnal temperature variation, wind speed, and sunshine duration.

Conclusions

This large-scale, 10-year study provides valuable information about the clinical characteristics associated with hMPV subtypes and climate factors contributing to virus transmission.
Historical–Geopolitical Contexts and the Transformation of Chinese Foreign Policy
Authors: Flint Colin , Xiaotong Zhang
Published: July 2019

In the past few years, China has made dramatic foreign policy decisions that have changed both the global landscape and the behaviour of other states. To understand fully the possibilities and limitations of China’s foreign policy, it is important to see its occurrences within geopolitical contexts. The main argument of this article is that geopolitical context must be theorised in order to understand the decisions of states. We define a political geography perspective within a world-systems analysis that creates a Space–Time matrix of context based on the core–periphery hierarchy of the capitalist world economy and economic and hegemonic cycles. Inspired by Chinese scholars and policymakers’ periodisations of Chinese diplomacy, we develop a new periodisation of Chinese diplomatic cycles from 1840 to 2039. Using this new periodisation of Chinese diplomacy, we situate the changing nature of Chinese foreign policy within our Space–Time matrix. We then evaluate the possibilities and challenges of China’s current foreign policy, with emphasis on the Belt and Road Initiative, by illustrating features of the contemporary geopolitical context. Finally, we discuss the implications of this for contemporary Chinese foreign policy.
A developmental network city? Double embeddedness in New York
Authors: Indergaard Michael
Published: July 2019

This article develops the concept of the “developmental network city” (DNC) to link the literatures on neo-developmental states and urban economic innovation. Applying the developmental network state (DNS) model to the case of New York City, it shows how the American DNS contributed to the rise of a New York DNC, which features localised discovery and governance. Most important here was that New York’s developmental agencies created a knowledge economy alternative to the “global financial centre” path by selectively adapting DNS ideas and resources to fit the city’s landscape of applied innovation.
Opportunities and risks of localised industrial policy: the case of “maker-entrepreneurial ecosystems” in the USA
Authors: Schrock Greg , Wolf-Powers Laura
Published: July 2019

Efforts in US cities to support the emergence of the “maker economy” could take urban-level industrial policy in a new direction. Optimistic projections about the potential of the maker economy for urban manufacturing revitalisation, however, downplay an enduring tension in local economic development between efforts to build endogenous capabilities and pressures to facilitate property value growth. Exploring maker industrial policy efforts in New York City and Portland, Oregon, we argue that local government actors often struggle to build network capacity and curb opportunism. District-based models hold promise, but the real estate-driven model of local development poses a persistent challenge.
Change in left atrial function predicts incident atrial fibrillation: the Multi-Ethnic Study of Atherosclerosis
Authors: Lim Daniel J , Ambale-Ventakesh Bharath , Ostovaneh Mohammad R , Zghaib Tarek , Ashikaga Hiroshi , Wu Colin , Watson Karol E , Hughes Timothy , Shea Steven , Heckbert Susan R , Bluemke David A , Post Wendy S , Lima João A C
Published: July 2019

Aims

Longitudinal change in left atrial (LA) structure and function could be helpful in predicting risk for incident atrial fibrillation (AF). We used cardiac magnetic resonance (CMR) imaging to explore the relationship between change in LA structure and function and incident AF in a multi-ethnic population free of clinical cardiovascular disease at baseline.

Methods and results

In the Multi-Ethnic Study of Atherosclerosis (MESA), 2338 participants, free at baseline of clinically recognized AF and cardiovascular disease, had LA volume and function assessed with CMR imaging, at baseline (2000–02), and at Exam 4 (2005–07) or 5 (2010–12). Free of AF, 124 participants developed AF over 3.8 ± 0.9 years (2015) following the second imaging. In adjusted Cox regression models, an average annualized change in all LA parameters were significantly associated with an increased risk of AF. An annual decrease of 1-SD unit in total LA emptying fractions (LAEF) was most strongly associated with risk of AF after adjusting for clinical risk factors for AF, baseline LA parameters, and left ventricular mass-to-volume ratio (hazard ratio per SD = 1.91, 95% confidence interval = 1.53–2.38, P < 0.001). The addition of change in total LAEF to an AF risk score improved model discrimination and reclassification (net reclassification improvement = 0.107, P = 0.017; integrative discrimination index = 0.049, P < 0.001).

Conclusion

In this multi-ethnic study population free of clinical cardiovascular disease at baseline, a greater increase in LA volumes and decrease in LA function were associated with incident AF. The addition of change in total LAEF to risk prediction models for AF improved model discrimination and reclassification of AF risk.
Screening relatives in arrhythmogenic right ventricular cardiomyopathy: yield of imaging and electrical investigations
Authors: Jurlander Rebecca , Mills Helen L , Espersen Kiri I , Raja Anna Axelsson , Svendsen Jesper Hastrup , Theilade Juliane , Iversen Kasper , Vejlstrup Niels , Bundgaard Henning , Christensen Alex Hørby
Published: July 2019

Aims

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited disease and presymptomatic screening of relatives is recommended. In 2010, the Task Force Criteria (TFC2010) introduced specific diagnostic imaging parameters. The aim of the study was to evaluate the diagnostic yield of family screening and the value of different diagnostic modalities.

Methods and results

Family evaluation, including cardiac magnetic resonance (CMR), is routinely offered to ARVC relatives at our institution. We retrospectively registered baseline characteristics, symptomatology, and results of non-invasive examinations from 2010 to 2016 and assessed the findings according to TFC2010. A total of 286 relatives (150 females; age 12–76 years; 251 first-degree) were included. A total of 103 (36%) individuals reported cardiovascular symptoms. The non-invasive workup showed that 101 (35%) relatives had ≥1 positive parameter on signal-averaged electrocardiogram (ECG), 40 (14%) had abnormal findings on Holter monitoring, 36 (13%) fulfilled an ECG criterion, six (2%) fulfilled CMR criteria, and echocardiographic abnormalities was seen in one (0.3%) relative. In total, 21 (7% overall; 13% among gene-positive subgroup) relatives were diagnosed with ARVC and 78 (27% overall; 49% among gene-positive subgroup) with borderline ARVC based on the combined non-invasive evaluations. Family history and electrical investigations alone diagnosed 20 out of 21 (95%) ARVC cases and 73 out of 78 (94%) borderline cases.

Conclusion

Consecutive evaluation of ARVC relatives diagnosed 7% with definite and 27% with borderline ARVC according to the TFC2010. Screening relatives for electrical abnormalities with 12 lead ECG, signal-averaged ECG, and Holter monitoring was more sensitive than imaging modalities.
Healthcare disparities for women hospitalized with myocardial infarction and angina
Authors: Jackson Alice M , Zhang Ruiqi , Findlay Iain , Robertson Keith , Lindsay Mitchell , Morris Tamsin , Forbes Brian , Papworth Richard , McConnachie Alex , Mangion Kenneth , Jhund Pardeep S , McCowan Colin , Berry Colin
Published: July 2019

Aims

Ischaemic heart disease persists as the leading cause of death in both men and women in most countries and sex disparities, defined as differences in health outcomes and their determinants, may be relevant. We examined sex disparities in presenting characteristics, treatment and all-cause mortality in patients hospitalized with myocardial infarction (MI) or angina.

Methods and results

We conducted a cohort study of all patients admitted with MI or angina (01 October 2013 to 30 June 2016) from a secondary care acute coronary syndrome e-Registry in NHS Scotland linked with national registers of community drug dispensation and mortality data. A total of 7878 patients hospitalized for MI or angina were prospectively included; 3161 (40%) were women. Women were older, more deprived, had a greater burden of comorbidity, were more often treated with guideline-recommended therapy preadmission and less frequently received immediate invasive management. Men were more likely to receive coronary angiography [adjusted odds ratio (OR) 1.52, confidence interval (CI) 1.37–1.68] and percutaneous coronary intervention (adjusted OR 1.68, CI 1.52–1.86). Women were less comprehensively treated with evidence-based therapies post-MI. Women had worse crude survival, primarily those with ST-elevation myocardial infarction (14.3% vs. 8.0% at 1 year, P < 0.001), but this finding was explained by differences in baseline factors. Men with non-ST-elevation myocardial infarction had a higher risk of all-cause death at 30 days [adjusted hazard ratio (HR) 1.72, CI 1.16–2.56] and 1 year (adjusted HR 1.38, CI 1.12–1.69).

Conclusion

After taking account of baseline risk factors, sex differences in treatment pathway, use of invasive management, and secondary prevention therapies indicate disparities in guideline-directed management of women hospitalized with MI or angina.