bluuebunny/crossref_metadata_2025 huggingface dataset:
Colecciones pancreáticas en pancreatitis aguda
Authors: Vargas Castillo Priscilla María , Mora Quesada Irene María
Published: July 2022

La pancreatitis aguda es uno de los trastornos gastrointestinales más comunes que se presentan en el servicio de emergencias y que requieren hospitalización. Los pacientes con una enfermedad de gravedad moderada a grave se encuentran con mayor riesgo de complicaciones, tanto locales como sistémicas, las cuales a su vez tienen mayores tasas de morbilidad y mortalidad. Es por ello que es tan importante la atención hacia los paciente con hallazgos sugestivos dichas complicaciones, especialmente ante colecciones líquidas peripancreáticas o pancreáticas y pancreatitis necrotizante aguda.
Vaginosis bacteriana en el embarazo: últimos avances hasta la fecha
Authors: Morelli Martinez Isabel , Gamboa Miranda Sofía
Published: July 2022

La vaginosis bacteriana está causada por un desbalance en las poblaciones bacterianas de la microbiota vaginal normal. Ciertas condiciones en las que ocurren cambios hormonales considerables, como el embarazo, pueden precipitar esta disbiosis. En la mayoría de los casos es asintomática; pero de no serlo, se presenta  con una secreción vaginal blanquecina, con mal olor, bastante característica. En cuanto a su fisiopatología, los factores de virulencia de las bacterias patógenas son los responsables de la disrupción del microambiente vaginal; y los factores de riesgo son en su mayoría los mismos que se vinculan con otras infecciones de transmisión sexual; sin embargo, también los niveles bajos de vitamina D se han asociado con esta. Su diagnóstico puede ser mediante hallazgos clínicos, histopatológicos o detección molecular; pero lo más reciente corresponde a pruebas rápidas de detección enzimática. Con respecto al tratamiento, en la mayoría de los casos, el consenso es a favor de tratar las pacientes sintomáticas; sin embargo, resulta incierto como se debe proceder con las pacientes asintomáticas.
Lesión renal aguda asociada a vancomicina
Authors: Montero Valverde Dany , Pacheco Muñoz Mariana , Abarca Brenes Ignacio
Published: July 2022

La vancomicina es un antimicrobiano de uso frecuente a nivel intrahospitalario para el tratamiento de infecciones graves por Staphylococcus aureus meticilino resistente, entre sus efectos secundarios de mayor cuidado se encuentra la nefrotoxicidad. Esta, en presencia de otros factores de riesgo propios del paciente, predisponen a la aparición de la lesión renal aguda.
Síndrome de HELLP, una triada que puede llegar a ser mortal
Authors: Araya Calvo Paula , Araya Villavicencio Sofía , González Carvajal Catalina
Published: July 2022

El síndrome HELLP es una complicación de la preeclampsia grave multisistémica caracterizada por una triada clásica compuesta por hemólisis, elevación de enzimas hepáticas y trombocitopenia. Sus complicaciones pueden llevar a la mortalidad materna e inclusive en más incidencia una mortalidad fetal. La etiología no está clara, sin embargo los factores de riesgo se asemejan a los de la preeclampsia. El tratamiento principal es la terminación del parto y este va de la mano de acuerdo a la edad gestacional de la paciente en el momento de presentarlo. Se debe realizar el diagnóstico e inicio de tratamiento de manera precoz y oportuna para así disminuir el riesgo de morbi-mortalidad.
Caso clínico: Tuberculosis osteoarticular; una causa infrecuente de dolor crónico en adultos jóvenes
Authors: Sauma Webb Alejandro , Marin Chavarria Diana Carolina
Published: July 2022

Se presenta el caso de un paciente masculino de 27 años con historia de omalgia izquierda crónica, con colección retropectoral izqueirda y lesiones osteoarticulares sospechosas de malignidad por lo que hospitaliza en el servicio de Medicina Interna del Hospital de Guápiles. Los estos estudios moleculares e histopatológicos evidencian la presencia de Mycobacterium tuberculosis en las lesiones descritas. Aproximadamente 20% de los casos de tuberculosis tienen evidencia de enfermedad extrapulmonar y de ellos, la variante osteoarticular se presenta en un 10% de los casos. El diagnostico suele ser un reto ya que usualmente su presentación puede confundirse con muchas otras patologías, entre ellas el cáncer. El diagnóstico debe ser confirmardo por pruebas histopatológicas, microbiológicas o moleculares. El tratamiento antifímico es más prolongado que el tratamiento de la tuberculosis pulmonar.
Sangrado uterino anormal: abordaje y manejo
Authors: Salazar Vargas Valeria
Published: July 2022

El sangrado uterino es una patología que se define como cualquier anormalidad ya sea en duración, volumen, frecuencia y/o regularidad en el sangrado menstrual. Es una entidad muy prevalente en adolescentes, mujeres edad fértil, así como pre y postmenopáusicas; diferenciándose causas estructurales como no estructurales; cada grupo etario posee sus particularidades en cuanto a etiologías; por lo que el abordaje debe ser siempre personalizado y con un enfoque escalonado. El tratamiento se categoriza en hormonal y no hormonal, tanto para el manejo agudo como el crónico; y cada uno de ellos debe apegarse a las necesidades de cada paciente en cuanto a comorbilidades, deseo de fertilidad y preferencias personales.
Effect of Acacia Honey Drink Consumed Pre and During Exercise on Glucose Metabolism, Total Antioxidant Status, and Running Performance in the Heat
Authors: Mohd Sukri Nursyuhada , Ooi Foong Kiew , Chen Chee Keong , Sirajudeen K.N.S
Published: July 2022

Introduction: This study investigated the effects of Acacia honey drink on glucose metabolism, plasma total antioxidant status, selected physiological parameters and time trial running performance in the heat compared to a commercially-available sports drink. Materials and methods: Ten participants completed two endurance running trials in the heat with either honey drink (H) or sports drink (SPD) ingestion. Honey drink or sports drink was ingested one hour prior to the experimental trials. Participants warmed up for 5 min by running at 50% of their respective VO2max, and subsequently ran at 60% of their respective VO2max for 1hour. This was immediately followed by a 20 min time trial running performance. Participants drank 3 mL.kg body weight-1 of cool honey or sports drink every 20 min during the trials. Blood samples were collected for subsequent biochemical analysis. Results: Plasma glucose, insulin, cortisol, total antioxidant status and running performance were not statistically different between H and SPD trials. These findings indicated that Acacia honey drink and sports drink ingested before and during exercise elicited similar effects on glucose metabolism and endurance running performance. Conclusion: Acacia honey has potential to be used as an alternative ergogenic aid for athletes who train and compete in a hot and humid environment.
Community-acquired Covid-19 Cluster among Non-Clinical Staff in a Teaching Hospital, Malaysia
Authors: Aizuddin Azimatun Noor , Hod Rozita , Hassan Mohd Rohaizat , Ahmad Norfazilah , Mohamed Nawi Azmawati , Daud Faiz , Arifin Mohd Afiq
Published: July 2022

A novel coronavirus, COVID-19 is responsible for the current outbreak of pneumonia. As of 16 September 2021, a total of 2,049,750 COVID-19 cases were recorded in Malaysia. In this study, we aimed to describe a cluster of COVID-19 cases among non-clinical staff in a teaching hospital in Kuala Lumpur Malaysia. We obtained epidemiological and clinical data from patients with confirmed COVID-19, via phone interviews and patient medical records. We performed chronological mapping of the cases to identify the possible period, mode of transmission, and cluster pattern. Three laboratory-confirmed COVID-19 cases were identified from the teaching hospital cluster. These three cases were linked epidemiologically to the religious gathering cluster in Malaysia. Seventy-four close contacts consisting of teaching hospital staff were quarantined. The median incubation period was four days (IQR 1-7). The need for intensified surveillance and a high level of alertness is vital to minimise the risk of widespread transmission in Malaysia.
Case Report: Lymphoepithelial Carcinoma of the Parotid Gland with EBV Association
Authors: Subramaniam S Darmma , Mansor Masaany
Published: July 2022

Primary Lymphoepithelial Carcinoma (LEC) of the salivary gland is a rarely encountered malignant tumour by Otorhinolaryngology surgeons especially in Malaysia. It accounts for an estimated 0.4% of all malignant tumours of head and neck with a racial predilection towards Eskimos, people of Southern Costal of China and Japanese. Histologically it exhibits a poorly differentiated neoplasm and a strong association with Epstein-Barr virus that could be similar to an undifferentiated nasopharyngeal carcinoma (NPC). The parotid gland is the most common location a Primary LEC of the salivary gland develops, with patients mostly presenting with a painless parotid swelling and cervical lymphadenopathy. Herein, the authors report a rare case of Primary LEC of the parotid in an unfortunate Malay female. In this case report we further highlight the pathological and radiological features including management of Primary LEC of the parotid as this tumour should be considered in all patients presenting with a painless parotid mass to an Otorhinolaryngology clinic.
Comparison of Doses in Organs at Risk of Conventional and Three-Dimensional Treatment Planning in Hybrid Brachytherapy
Authors: Chen Suk Chiang , Mohd Ramli Fathin Atika , Abdullah Reduan , Mohd Zahri Abdul Aziz
Published: July 2022

INTRODUCTION: This retrospective study aims to evaluate the doses of organs at risk (OARs) calculated by conventional two-dimensional (2-D) and three-dimensional (3-D) treatment planning techniques in hybrid high dose rate (HDR) brachytherapy for cervical cancer. MATERIALS AND METHODS: Data of five patients treated with combination of intracavitary and interstitial brachytherapy were used. For each implant, computed tomography (CT) images were obtained, and the clinical target volume and OARs were contoured on CT images. In 3-D planning, the volumes of OARs were derived from dose-volume histogram (DVH) on a dose volume of 2 cc for bladder, rectum, and sigmoid. The OARs defined in replanning for 2-D treatment were the ICRU-38 bladder (bICRU) and rectum (rICRU) points. Paired T-tests were used to analyse the radiation doses of bladder and rectum obtained from both techniques. RESULTS: The mean point doses evaluated via bICRU) and rICRU were 89.34 GyEQD2 and 75.92 GyEQD2, respectively. Meanwhile, the mean volumetric doses of D2cc for bladder and rectum were 80.50 GyEQD2 and 69.08 GyEQD2, respectively. There is a significant difference in mean doses of ICRU point and D2cc volume for bladder (p<0.05). However, there is no significant difference in mean doses of ICRU point and D2cc for rectum (p>0.05). Overall, ICRU point doses overestimated volumetric D2cc doses with a mean dose ratio of 1.110 for bladder and 1.099 for rectum respectively. CONCLUSION: The bICRU in 2-D planning could not represent the bladder 2 cc used in 3-D planning, thus resulting in different total dose; whereas rICRU of 2-D planning was discovered to be similar with rectum 2 cc of 3-D planning and deemed reliable in total dose estimation
Cognitive Behavioural Therapy for Chronic Pain Management: A Narrative Review
Authors: Liang Carolyn , Ahmad Mahadir
Published: July 2022

Chronic pain is disabling and impacts an individual’s psychosocial and functioning in multiple areas. Cognitive Behavioural Therapy (CBT) appears to be one of the psychotherapies that has good potential of prominent efficacy in managing chronic pain. This narrative review aims to provide the necessary information and latest development on the delivery, results efficacy and barriers of CBT in chronic pain management. A search was conducted at Pubmed and Web of Science in April 2021 yielding a total of 251 articles. After careful screening and filtration, a total of 21 articles was selected for this review. Of these 21 articles, CBT was observed to be commonly delivered through online, which helped to preserving cost, promoting adherence, having good efficacy and also safer during the time of the Covid-19 pandemic. Most of the articles showed significant efficacy of CBT in chronic pain management. In order to improve CBT for better efficacy, understanding and consideration towards mediators that affect pain outcome and barriers in implementation are crucial in developing modules in CBT for chronic pain management. As such, CBT can be improved by integrating customised components in the modules to target mediators specifically, and training can be provided for psychotherapist to combat the barrier of online communication and time management. For future research, direction can be focused on development of CBT modules that are specific to chronic pain management.
Islam, Iman, and Ihsan: The Role of Religiosity on Quality of Life and Mental Health of Muslim Undergraduate Students in Islamic University
Authors: Abdul Khaiyom Jamilah Hanum , Tajul Ariffin Arina Hanis , Md Rosli Ahmad Nabil
Published: July 2022

INTRODUCTION: The current study examines the relationships between religiosity, quality of life, and positive mental health among Muslim students in an Islamic university in Malaysia. This study uses the operational definition of religiosity based on Hadith Jibril, which defined Islam into three elements: Islam, Iman, and Ihsan. Materials and Methods: One hundred and seventy-nine students participated in this cross-sectional study. Three measures were used to measure religiosity (IIUM Religiosity Scale), quality of life (WHO Quality of Life-BREF Scale), and positive mental health (Positive Mental Health Scale). Results: Significant relationships between religiosity, quality of life, and positive mental health were found. Further analysis found that i) Ihsan highly predicts the physical and psychological domains of quality of life and mental health; ii) Islam shows the highest prediction on social-based quality of life, and iii) Iman highly predicts the environmental-based quality of life. Conclusion: Religiosity plays a vital role in predicting an individual’s quality of life and mental health. These findings provide hope for future research and utilisation of Islamic elements as an intervention for psychological wellbeing among students.
Innovative approaches in functional chocolate production
Authors: Çelik Kıvılcım , Günç Ergönül Pelin , Çelik Simge
Published: July 2022

Chocolate; It is a foodstuff obtained by using cocoa products, sugars and/or sweeteners, milk or dairy products and additives and/or flavorings permitted in the Turkish Food Codex Regulation. Cocoa (Theobroma cocoa), the raw material of chocolate, positively affects heart health, due to the minerals, polyphenols, and high antioxidant activity. Functional foods are foods that do not contain synthetic components and have health and well-being promoting properties as well as nutritious effects. For a food to be functional, it must contain factors such as bioactive components, probiotic microorganisms and prebiotic substances. Today, consumers to be healthier to their nutrition and turn to products with reduced fat and calorie content. Since chocolate is a high-calorie food with its high fat and sucrose ratio, its consumption is at a low rate. To positively affect human health, functional chocolate is produced by using probiotic microorganisms, adding ingredients such as inulin, polydextrose, sweeteners, different fat substitutes to it, reducing the amount of sugar and fat, and increasing the antioxidant capacity. In this review, the developments in chocolate production from year to year, what is functional chocolate, studies on functional chocolate and the health aspect of chocolate composition are examined.
Optimization of the inertial mass of the brake roller stand
Authors: Мarmut Іhоr , Kashkanov Andriy , Kashkanov Vitaliy , Sebko Dmitry
Published: July 2022

The article deals with the issues of modeling conditions for obtaining diagnostic information when checking the braking properties of cars on a roller stand.As many studies show, roller stands of inertial type provide the most reliable information about the technical condition of the car. This concern, first of all, the parameters that determine the accuracy of simulation on the stand of real speed and thermal conditions. The accuracy of diagnosing the brake system of a car on an inertial test bench depends on many factors. One of the determining factors is the value of the reduced masses of rotating elements in the "car-stand" system: rollers, wheels and car transmission parts. The main design parameter of the inertial roller stand is the diameter of the roller. The reduced mass of the transmission can be determined by measuring the moments of inertia of its individual parts and bringing them to a given axis. But this is a laborious process and takes a lot of time. At the same time, the reduced mass of the transmission is also variable due to the wear of parts. Therefore, methods are required to determine the reduced mass of the transmission of a particular vehicle, regardless of the degree of wear of parts.To determine the reduced mass of the transmission, two modes of acceleration of the car on the stand are used: acceleration from the drive of the stand, while two wheels of the car rotate; acceleration from the stand drive, in which one wheel of the car rotates. The analysis of these modes is made and the equations for determination of the reduced mass of transmission are made.The analysis of changes in the moments of inertia of the wheel and rotating parts of the car, as well as the radius of the wheel is carried out. Based on this, the general variation of the reduced mass of the wheel and associated rotating parts of the vehicle is presented. This variation can have a significant impact on the accuracy of diagnosis. The optimal way to compensate for this uncertainty may be to increase the reduced mass of the stand so that the proportion of the reduced mass of the wheel and the associated rotating parts of the car is a small part and introduces an error no more than acceptable.
Perioperative risk stratification of spine trauma patients with ankylosing spinal disorders: a comparison of 3 quantitative indices
Authors: Lakomkin Nikita , Mikula Anthony L. , Pinter Zachariah W. , Wellings Elizabeth , Alvi Mohammed Ali , Scheitler Kristen M. , Pennington Zach , Lee Nathan J. , Freedman Brett A. , Sebastian Arjun S. , Fogelson Jeremy L. , Bydon Mohamad , Clarke Michelle J. , Elder Benjamin D.
Published: July 2022

OBJECTIVE

Patients with ankylosing spinal disorders (ASDs), including ankylosing spondylitis (AS) and diffuse idiopathic skeletal hyperostosis (DISH), have been shown to experience significantly increased rates of postoperative complications. Despite this, very few risk stratification tools have been validated for this population. As such, the purpose of this study was to identify predictors of adverse events and mortality in ASD patients undergoing surgery for 3-column fractures.

METHODS

All adult patients with a documented history of AS or DISH who underwent surgery for a traumatic 3-column fracture between 2000 and 2020 were identified. Perioperative variables, including comorbidities, time to diagnosis, and number of fused segments, were collected. Three instruments, including the Charlson Comorbidity Index (CCI), modified frailty index (mFI), and Injury Severity Score (ISS), were computed for each patient. The primary outcomes of interest included 1-year mortality, as well as postoperative complications.

RESULTS

A total of 108 patients were included, with a mean ± SD age of 73 ± 11 years. Of these, 41 (38%) experienced at least 1 postoperative complication and 22 (20.4%) died within 12 months after surgery. When the authors controlled for potential known confounders, the CCI score was significantly associated with postoperative adverse events (OR 1.20, 95% CI 1.00–1.42, p = 0.045) and trended toward significance for mortality (OR 1.19, 95% CI 0.97–1.45, p = 0.098). In contrast, mFI score and ISS were not significantly predictive of either outcome.

CONCLUSIONS

Complications in spine trauma patients with ASD may be driven by comorbidity burden rather than operative or injury-related factors. The CCI may be a valuable tool for the evaluation of this unique population.
Menopausal Symptoms among Postmenopausal Women Visiting Outpatient Department of a Tertiary Care Centre: A Descriptive Cross-sectional Study
Authors: Subedi Anjali , Shrestha Junu , Chaudhary Jainath Kumar
Published: July 2022

Introduction: Menopause is defined as the complete cessation of menstruation for consecutive 12 months which occurs due to the loss of follicular activity of ovaries from the late 40s to early 50s. The menopausal symptoms are often distressing but lack of awareness leads to failure in addressing the problem. This study aimed to find out the prevalence of menopausal symptoms among postmenopausal women visiting the outpatient department of a tertiary care centre.
Methods: This descriptive cross-sectional study was done among postmenopausal women in the outpatient department of a tertiary care centre from 10 March 2021 to 10 March 2022 after taking ethical approval from the Institutional Review Committee (Reference number: MEMG/IRC/420/GA). Convenience sampling was done. Demographic data were collected using predesigned proforma and menopausal symptoms were evaluated using Rajanobritta Lakshan Mapak, the Nepali version of the menopausal rating scale. Point estimate and 95% Confidence Interval were calculated.
Results: Among 424 postmenopausal women, menopausal symptom was found in 411 (96.48%) (94.73-98.23, 95% Confidence Interval). The mean age at menopause was 49±4.70 years. The most common symptom these women presented with was somatic symptoms seen in 382 (92.94%) women.
Conclusions: The prevalence of menopausal symptoms is found to be higher than the other studies done in similar settings.
Optic Pathway Edema Mimicking Multifocal/Multicentric Glioblastoma Multiforme: A Case Report and Review
Authors: Liang E.S. , Winter C.D. , Murthy K.
Published: July 2022

Multifocal/multicentric glioblastoma is a rare variant of glioblastoma that carries a worse prognosis than singular glioblastoma. We report a case of optic nerve edema mimicking multifocal/multicentric glioblastoma in a 24-year-old man. It was suspected that the pathophysiology of edema
was due to mechanical compression of the optic nerve causing axonal transport disruption as well as vasogenic edema from inflammatory response to the tumor.
A Comprehensive Clinical Review of Adult-Type Diffuse Glioma Incorporating the 2021 World Health Organization Classification
Authors: Currie S. , Fatania K. , Matthew R. , Wurdak H. , Chakrabarty A. , Murray L. , Short S.
Published: July 2022

The intent of this article is to provide a comprehensive, educational review of adult-type diffuse gliomas, bringing together the role of the multidisciplinary team and giving the reader biologic, surgical, radiologic, and oncologic insight into these tumors. The reader will be guided
through subsections that explain the molecular pathophysiology, diagnosis, treatment, prognosis and natural history of the disease. The 2021 World Health Organization Classification will be explained through a combination of concise historic review of glioma diagnosis and contemporary knowledge
of the molecular pathways. Accompanying illustrations will act as powerful tools for comprehension. These concepts will be underpinned by frequent reference to neuroradiology and a grounding of normal brain composition.Learning Objective: To understand the pathophysiologic concepts that
underly the World Health Organization Classification and natural history of adult-type diffuse gliomas and how these relate to imaging and treatment strategies
Impact of Education on Poverty Alleviation in Afghanistan: An Empirical Evaluation
Authors: Wani Nassir Ul Haq , Dhami Jasdeep Kaur , Sidana Neeru
Published: July 2022

Afghanistan has one of the lowest education levels and where 49.6 percent of the population lives under the poverty line. Moreover, poverty in Afghanistan is concentrated in rural areas and four out of five poor people live in poverty. The East, Northeast, and West-Central regions—where almost half of the inhabitants are poor—have the lowest per capita consumption and highest likelihood of poverty. In cognizance of the vitality of Sustainable Development Goals (SDGs) and education is promulgated as the primary weapon against poverty prevalence. Hence it is crucial to seek out the effect of different levels of education on poverty in Afghanistan. This study evaluates the effect of different levels of education, experience, and gender of the employed individuals (employers, self-employed, wage earners, and unpaid family workers) as the determinants of poverty. The data is collected from the Living Conditions Survey for 2008 and 2019. A logistic regression model is estimated based on data, with the probability of an individual being poor as the dependent variable and a set of educational levels, experience, and gender as explanatory variables. Further, the study identifies deficiencies related to basic education in poverty reduction and comes up with some policy conclusions that can be taken into account in the planning of effective basic education for poverty reduction.
La sécheresse croissante met-elle en danger l’effet protecteur de la forêt?
Authors: Moos Christine , Métral Roland
Published: July 2022

L’importance économique et sociale des forêts de protection est reconnue comme prioritaire sur le plan suisse. Des périodes de sécheresse plus fréquentes à basse altitude pourraient toutefois entraîner à l’avenir des pertes temporaires de l’effet protecteur. A l’aide de l’exemple concret d’une forêt protectrice au-dessus de Martigny, une modélisation dynamique de ce massif forestier associée à une analyse quantitative des risques a été réalisée. Cet article présente les effets modélisés du changement climatique sur la fonction de protection de la forêt contre les chutes de pierres. Il intègre aussi les expériences pratiques de la gestion de ce massif forestier durant ces 40 dernières années. En effet, de fortes interventions y ont été réalisées pour éviter la présence de hêtres de gros diamètre et introduire un rajeunissement avec un mélange varié d’essences. Le modèle prévoit une nette diminution de la surface terrière avec une disparition progressive du hêtre au profit du chêne pubescent, de feuillus divers et du pin sylvestre. Selon la simulation, le risque de chutes de pierre devrait doubler d’après le scénario modéré et presque tripler d’après le scénario extrême d’ici 150 ans. Les résultats fournis par le modèle incitent à continuer à rajeunir le versant par ouvertures en fente et à favoriser la présence des feuillus. Cependant, l’intensité des interventions devrait diminuer d’ici 50 ans avec la baisse de l’accroissement et de la surface terrière. Il reste difficile de prévoir dans quelle proportion les effets de la baisse de la surface terrière seront partiellement compensés par l’évolution du mélange des essences avec une grande densité de tiges de petits diamètres et une forte présence de buissons. A notre avis, des interventions encore plus ciblées sur un mélange d’essences résistantes devraient diminuer l’effet négatif lié à l’augmentation de périodes de sécheresse.
Research on Diagnosis and Prognosis of Cervical Cancer in FOXD1
Authors: Liu Fang
Published: July 2022

The aim of the present study was to investigate the diagnostic and prognostic value of FOXD1 in cervical carcinoma. 24 patients with cervical carcinoma were the sample for this study. Human cervical carcinoma cell lines (AV3, Hela229, CaSki and Hela cells) and cervical normal cell line (UVECs) were used in this study for vitro model. FOXD1 mRNA expression level was up-regulated in the tissue of cervical cancer, compared with paracancerous tissue group. FOXD1 mRNA expression level in I-II patients with cervical cancer was lower than those of III-IV patients with cervical cancer. Overall survival (OS) and disease-free survival (DFS) of FOXD1 high expression were lower than those of FOXD1 low expression. FOXD1 mRNA expression level was induced in cervical cancer cell lines, compared with UVECs cell. In conclusion, serum FOXD1 expression was the diagnostic and prognostic value for cervical carcinoma, and promotes cell growth and metastasis via Warburg effect by CTGF.
Circular RNA TOP2A Promotes Apoptosis and Suppresses Cell Viability of Ox-LDL-induced HAEC Cells via Sponging MicroRNA-27a-3p
Authors: He Yi
Published: July 2022

This study explored impacts of circular RNA TOP2A and miR-27a-3p on HAECs after ox-LDL treatment. RNA expressions of circRNA TOP2A and miR-27a-3p were assessed by RT-qPCR in normal and ox-LDL-treated HAECs, showing circRNA TOP2A was inhibited and miR-27a-3p was upregulated after ox-LDL treatment. HAECs viabilities were promoted by ox-LDL treatment but overexpressed circRNA TOP2A suppressed the cell viability. Moreover, Ki-67 protein expression was downregulated while cleaved caspase-3 was inhibited. MiR-27a-3p was then confirmed to be sponged and suppressed by circRNA TOP2A while miR-27a-3p mimics promoted its expression. Additionally, decreased cell viability caused by overexpressed circRNA TOP2A was also reversed by miR-27a-3p overexpression. Furthermore, downregulated Ki-67 and increased cleaved caspase-3 protein expressions caused by circRNA TOP2A upregulation were also restored by overexpressed miR-27a-3p, resulting in promoted Ki-67 and decreased cleaved caspase-3.
Pluripotent Stem Cells – Potential Uses in the Pharmaceutical Field
Authors: Femeela A. Ireen
Published: July 2022

The cells can divide and differentiate into several types of cells in an organism. It is not able to differentiate as the extraembryonic tissues, which are termed as the ‘pluripotent cells’. The transcription factors such as, SOX-2, C-MYC, OCT-4 and KLF-4 are involved in the maintenance of pluripotency. Pluripotent stem cells (PSCs) can self-renewal cells, which may be either induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs). Pluripotent cells can be used in the treatment of diseases like cancer, cosmetics and the healing of skin burns. The current review majorly focuses on the PHCs along with their history, their molecular markers and major transcription factors in a brief manner. The techniques including sensors and assays used for the assessment of pluripotency have also been discussed.
The Relationship between the Living Environment and People Attitudes towards Healthcare System. Case of Russia and Romania
Authors: Bulatnikov V.V. , Constantin C.P.
Published: July 2022

This article focuses on the problems of healthcare systems in Russia and Romania from the perspective of patients due to the current requirement to address the improvement of healthcare systems from the customer perspective. The article’s purpose is to identify the patients’ attitudes towards the main problems of the systems in the two countries and their satisfaction with public clinics. These attitudes were analyzed in relationship with the residence area of the respondents (urban or rural). The results of this research can assist decision-makers in finding problems that demand specific upgrades, adjustments, and innovations in healthcare. An electronic survey was conducted on over 400 persons from Russia and Romania. The results reveal that in Russia the problems of the healthcare system are not appreciated differently by the urban and rural residents, while in Romania the rural population is more concerned about these problems. Instead, the analysis of satisfaction with public clinics reveals opposite results.
Sensory Evaluation and Nutritional Quality of Corn Tortilla Enriched with Moringa Seed Flour
Authors: Nur Astuti , Sine Juni Gressilda L. , Nita Maria Helena Dua
Published: July 2022

One of the agricultural product processing industries currently being developed in East Nusa Tenggara is corn. Corn has a relatively high nutritional content, thus it possesses economic value for the community. One of the snack products from corn is tortilla. The tortillas can be modified with other food ingredients that contain good nutrition to increase its nutritional value. Moringa seeds contain carbohydrates, fats and proteins. Hence, moringa seeds can be an alternative food source of a new protein which is able to overcome protein deficiency, particularly in East Nusa Tenggara. The experiment was designed by Completely Randomized Design (CRD) with several formulas for substitution of corn flour with moringa seed flour, which were: P1 (100%: 0%), P2 (95%:5%), P3 (90%:10%), and P4 (85%:15%). An organoleptic test was administered to determine the panelists' preference for tortilla formulas and a proximate test to examine the nutritional value of tortillas. The results of the organoleptic test revealed that corn tortilla substituted with moringa seed flour up to 20% owned a significant effect on the color, aroma, taste and texture of the tortilla with a p-value <0.05. The proximate test results presented that tortillas with moringa seed flour substitution possessed a significant effect on protein, fat, carbohydrate, water, ash and fibre content of tortilla with a p-value <0.05.
The Role of Parkinson Nurses for Personalizing Care in Parkinson’s Disease: A Systematic Review and Meta-Analysis
Authors: van Munster Marlena ,   iCARE-PD consortium, Stümpel Johanne , Thieken Franziska , Ratajczak Florin , Rascol Olivier , Fabbri Margherita , Clemens Timo , Czabanowska Katarzyna , Mestre Tiago A. , Pedrosa David J.
Published: July 2022

Background: Quality of life (QoL) of persons with Parkinson’s disease (PD) is diminished by (non-)motor symptoms, that require personalized care. Parkinson Nurses (PN) may be pivotal promoting tailored care offerings. This systematic review and meta-analysis investigates PD care models and aims at furnishing current concepts of PN to offer personalized care. Objective: The purpose of this study is to identify the various roles and functions that PN may hold for personalized PD care. Methods: We performed a systematic literature review, utilizing: PubMed, Web of Science, The Cochrane Library, and PsycINFO. The review qualitatively evaluated articles, which described personalized care models involving PNs and was guided by the personalized care management model. A meta-analysis compared patient-reported QoL (quantified using the 39-item Parkinson’s Disease Questionnaire) between personalized care interventions involving PN versus standard care with. Results: Twenty-seven publications were identified, including six randomized, controlled trials ascertaining with health related QoL (n = 1830 PwPs). The qualitative evaluation revealed that PN contribute to all aspects of personalized care. The meta-analysis showed no improved QoL in personalized care models compared to standard care, thought a great heterogeneity among study design and interventions was outlined (Standardized Mean Difference = –0.8935; 95% Confidence Interval, –2.1177 to 0.3307; z = –1.43, p = 0.1526). Conclusion: PN fulfil important functions in personalized PD care. For the future, a clear role definition will be necessary to adjust training for PN across healthcare systems and care settings but especially to realize their full potential for PD care.
НЕОБХІДНІСТЬ УДОСКОНАЛЕННЯ МЕТОДИК ВОГНЕВИХ ВИПРОБУВАНЬ ВОГНЕГАСНИХ ПОРОШКІВ ДЛЯ ГАСІННЯ МЕТАЛІВ
Authors: Voytovych D. P. , Sukach R. Yu.
Published: July 2022

Вступ. Гасіння пожеж з горінням металів пов’язане з рядом труднощів. Зокрема, існує певна невизначеність у виборі вогнегасних порошків, придатних для гасіння того чи іншого металу, відповідних технічних засобів пожежогасіння, а також нормованих параметрів подавання вогнегасних речовин, у тому числі в умовах горіння декількох горючих матеріалів різної природи одночасно. Вирішення цих проблем дасть змогу підвищити ефективність боротьби з пожежами, що супроводжуються горінням металів.Мета та задачі досліджень. Метою роботи було обґрунтування напрямів досліджень з підвищення ефективності гасіння пожеж класу D розробленням методик випробувань вогнегасних порошків, призначених для їх гасіння. З цією метою необхідно було проаналізувати документи, якими регламентовано порядок визначення вогнегасної ефективності порошків під час гасіння металів, а також літературні дані щодо вогнегасних порошків, призначених для гасіння пожеж класу D і технічних засобів їх подавання.Методи. Для досягнення мети та реалізації поставлених задач застосовано аналітичний метод. Проаналізовано методи оцінювання вогнегасної ефективності вогнегасних порошків під час гасіння пожеж класу D, регламентовані стандартами ISO 7165, ГОСТ Р 53280.5, методику, запропоновану в Україні, дані щодо таких порошків, насадок-заспокоювачів для їх подавання, а також сучасні підходи до удосконалення існуючих методів.Результати дослідження. Вивчено необхідність удосконалення рецептур вогнегасних порошків для гасіння металів, насадок-заспокоювачів для їх подавання, а також відповідних технічних засобів пожежогасіння. Обґрунтовано потребу в подальших роботах з удосконалення таких методів, розроблення методів оцінювання ефективності порошків для гасіння горючих металів, а також їхньої сумісності з вогнегасними речовинами інших типів під час гасіння пожеж, що супроводжуються горінням речовин і матеріалів різної природи.Висновки. Для розроблення відповідних методик запропоновано взяти за основу методи випробування з визначення вогнегасної ефективності порошків для гасіння пожеж класу D, передбачені ISO 7165, а також сумісності вогнегасних порошків з повітряно-механічною піною, регламентований EN 615. Встановлено, що для забезпечення єдності вимірювань необхідно використовувати випробувальний пристрій типу вогнегасника з унормованими параметрами, а також насадку-заспокоювач заданої конструкції. Створення таких методів дасть змогу визначати вогнегасну ефективність порошків для гасіння тих чи інших горючих металів без огляду на характеристики використовуваних технічних засобів пожежогасіння, а також оцінювати нормовані параметри подавання вогнегасних порошків (тривалість подавання, питома витрата тощо) технічними засобами, в тому числі стаціонарними системами пожежогасіння.
ВОГНЕГАСНІ ВИПРОБУВАННЯ КОНЦЕНТРОВАНОГО ВОДНОГО РОЗЧИНУ ФЕРУМ(ІІІ) СУЛЬФАТУ
Authors: Karvats’ka M. Ya. , Pastuhov P. V. , Petrovskii V. L. , Lavrenyuk O. I. , Mykhalitchko B. M.
Published: July 2022

Вступ. Одним з пріоритетних завдань пожежної безпеки і, зокрема, пожежогасіння є пошук нових вогнегасних речовин, здатних проявляти чималу вогнегасну дію, тобто дуже ефективно призупиняючи поширення полум’я. З огляду на це, перспективними речовинами, які можна було б використати для розробки водних вогнегасних речовин нового покоління, є неорганічні солі феруму, атоми d-металу яких можуть проявляти неабияку схильність до хімічного зв’язування як з гетероатомами різних горючих речовин, так і з активними частинками полум’я.Мета. Провести випробування вогнегасних властивостей концентрованого водного розчину ферум(ІІІ) сульфату та експериментальним шляхом встановити кількісні параметри аерозольного гасіння осередку займання класу «В».Методи. Вогнегасні випробовування концентрованого водного розчину ферум(ІІІ) сульфату на відкритому просторі, проводили за розробленою методикою на установці для гасіння полум'я, що складається з пневматичного розпилювача (Record 2200 ESO) з вбудованою ємністю (0,5 л) і насадкою розприскувача ( 1,2 мм), балона зі стисненим повітрям, оснащеного редуктором для створення тиску в системі випробувань (мінімум 6–8 атм) і манометрами з верхньою межею 1,6 МПа, а також круглим деком ( 40 см) з горючою рідиною (дизельне паливо з додаванням бензину, марки А-95 (ДСТУ 3675-98)).Результати. В умовах проведення випробування тривалість гасіння осередку займання (вогнище класу «В», площею 0,126 м2) 40% водним розчином ферум(ІІІ) сульфату становить 5 с. Вогнегасна ефективність водної вогнегасної речовини стосовно води з урахуванням тривалості та витрат на гасіння вуглеводневого полум’я підвищується у 4,9 раза.Висновки. Експериментальні дослідження показали, що нетривала дія аерозолем 40% водного розчину ферум(ІІІ) сульфату безпосередньо на полум’я зумовлює його доволі ефективне гасіння. Встановлено, що в умовах експерименту тривалість гасіння полум’я аерозолем водної вогнегасної речовини становить 5 с, що у 4,9 раза ефективніше за гасіння водою. Мінімальний об’єм витраченого 40% водного розчину ферум(ІІІ) сульфату на гасіння полум’я становить 0,2 л/м2.
PENGARUH REWARD DAN PUNISHMENT TERHADAP KINERJA POLISI DI POLRES CILACAP
Authors: Jayanti Esih , Andi Akhmad Husain
Published: July 2022

Human resources are one of the main roles in an organization, including the Indonesian National Police. The higher the ability of the unit member in the Police, the higher its performance. In order for the police performance in the Cilacap Regional Police Station to be consistent and maximal, the organization must pay attention to the factors that can affect a person's ability to carry out their duties and responsibilities such as the application of rewards and punishments. This study aims to examine and analyze the effect of, Reward and Punishment on Police Performance in the Cilacap Regional Police Station. This research method is descriptive quantitative, with purposive sampling technique. The sample in this study were 93 respondents who were police officers at the Cilacap Regional Police Station. To determine the magnitude of the influence of reward, and punishment on police performance, multiple linear regression analysis was used. The F test is used to examine the overall effect between Reward and Punishment with degrees of freedom (df) = k and (n-k-2) with confidence level (α = 0.05). To find out the partial effect, the T test of degrees of freedom (df) = k and (n-k-2) was used with a confidence level (α = 0.05). The results of the test can be concluded that both partially and simultaneously, reward and punishment affect the police performance in the Cilacap Regional Police Station.
PENGARUH KUALITAS PRODUK, HARGA, LOKASI, DAN KUALITAS PELAYANAN TERHADAP LOYALITAS KONSUMEN MELALUI KEPUASAN KONSUMEN SEBAGAI VARIABEL INTERVENING (PADA BENTO KOPI)
Authors: Juniarti Sri , Zuraida Lukia , Wikaningtyas Suci Utami
Published: July 2022

Penelitian ini bertujuan untuk mengetahui pengaruh kualitas produk, harga, lokasi, dan kualitas pelayanan terhadap kepuasan konsumen, mengetahui pengaruh kepuasan konsumen terhadap loyalitas konsumen, serta mengetahui pengaruh kualitas produk, harga, lokasi, dan kualitas pelayanan terhadap loyalitas konsumen melalui kepuasan konsumen sebagai variabel intervening. Populasi pada penelitian ini yaitu konsumen Bento Kopi UAD yang pernah berkunjung minimal 1 kali. Teknik pengambilan sampel yang digunakan merupakan teknik non-probability yaitu teknik purposive sampling, dengan jumlah sampel sebanyak 100 responden. Metode analisis data yang digunakan pada penelitian ini yaitu analisis jalur dengan bantuan program olah data SPSS versi 23. Hasil penelitian menunjukkan bahwa melalui hasil analisis jalur diketahui terdapat satu variabel yang berpengaruh signifikan terhadap kepuasan konsumen yaitu kualitas produk. Sedangkan variabel yang tidak berpengaruh signifikan terhadap kepuasan konsumen yaitu harga, lokasi, dan kualitas pelayanan. Serta, terdapat pengaruh signifikan terhadap loyalitas konsumen yaitu kepuasan konsumen. Selanjutnya, berdasarkan hasil uji sobel diperoleh hasil bahwa variabel yang berpengaruh terhadap loyalitas konsumen melalui kepuasan konsumen sebagai variabel intervening yaitu kualitas produk, sedangkan variabel yang tidak berpengaruh terhadap loyalitas konsumen melalui kepuasan konsumen sebagai variabel intervening yaitu harga, lokasi, dan kualitas pelayanan.
PENGARUH BUDAYA ORGANISASI, LOCUS OF CONTROL DAN STRES KERJA TERHADAP KEPUASAN KERJA PADA SUPER DAZZEL CABANG YOGYAKARTA
Authors: Pawestri Wuri , Nurwahyudi Muhammad Robi , Alboneh Zaenab
Published: July 2022

Job satisfaction is a condition where employees feel satisfied with their work. People who express high satisfaction in their work tend to be more productive. The purpose of this study was to analyze the influence of organizational culture, locus of control and job stress on job satisfaction. This research was conducted on 40 respondents at Super Dazzel Yogyakarta Branch.The method used in this research is quantitative with classical assumption test and multiple linear regression analysis, namely between organizational culture variables (X­1), locus of control (X2), and job stress (X3) on job satisfaction (Y), F test ( simultaneous), t-test (partial) in order to determine how much influence locus of control organizational culture and job stress have on employee job satisfaction at Super Dazzel Yogyakrata Branch.Based on the results in this study, in general, organizational culture, locus of control and job stress have a significant effect on job satisfaction.
PENGARUH KUALITAS PELAYANAN, KERAGAMAN PRODUK, DAN LOKASI TERHADAP KEPUASAN KONSUMEN
Authors: C.H. Qurrata A’yunina , Asrini Yuyun Dwida , Setyawati Rufaida
Published: July 2022

Penelitian ini dilatar belakangi oleh kebutuhan masyarakat terhadap segala sesuatu yang berkaitan dengan kesehatan. Selain ingin mendapatkan produk yang diinginkan, masyarakat juga mengharapkan pelayanan yang baik dan prima dari penyedia produk, dalam hal ini adalah karyawan apotek. Selain itu lokasi yang strategis, aman dan nyaman menjadi tolak ukur apakah masyarakat merasa puas dengan apa yang telah ditawarkan oleh apotek. Penelitian ini bertujuan untuk mengetahui dan menganalisa pengaruh kualitas pelayanan, keragaman produk, dan lokasi pada Apotek K-24 Kadipiro Yogyakarta. Sampel penelitian ini adalah konsumen yang pernah melakukan pembelian produk di Apotek K-24 Kadipiro Yogyakarta minimal sebanyak 1 kali.

Teknik pengambilan sampel yang digunakan adalah purposive sampling, yaitu teknik penelitian sampel dengan pertimbangan tertentu yang telah ditentukan terlebih dahulu oleh peneliti. Metode analisis statistik yang terdiri dari analisis regresi linear berganda, pengujian signifikan simultan (uji F), pengujian signifikan parsial (uji t), dan analisis determinasi (R2). Pengujian analisis determinasi (R2) menyatakan nilai Adjusted R Square 55,3%. Hal ini berarti bahwa variabel kualitas pelayanan, keragaman produk, dan lokasi terhadap kepuasan konsumen memiliki kontribusi 55,3%. Pengujian secara parsial (uji t) diketahui bahwa variabel kualitas pelayanan, keragaman produk, dan lokasi berpengaruh signifikan terhadap kepuasan konsumen. Pengujian secara simultan (uji F) diketahui bahwa variabel kualitas pelayanan, keragaman produk, dan lokasi secara bersama-sama (simultan) berpengaruh signifikan terhadap kepuasan konsumen.
PENGARUH LIKUIDITAS, PROFITABILITAS, LEVERAGE DAN UMUR PERUSAHAAN TERHADAP AUDIT DELAY
Authors: Suminar Cita Ayu , Zulkifli Zulkifli , Kundala Manendha Maganitri
Published: July 2022

Penelitian ini bertujuan untuk menganalisis pengaruh likuiditas, profitabilitas, leverage dan umur perusahaan terhadap audit delay pada perusahaan LQ-45 yang terdaftar di Bursa Efek Indonesia tahun 2017-2020. Metode pengambilan sampel yang digunakan adalah purposive sampling dan diperoleh sampel sebanyak 22 perusahaan. Metode penelitiannya menggunakan metode kuantitatif dengan melakukan regresi linier berganda antara variabel likuiditas, profitabilitas, leverage dan umur perusahaan terhadap audit delay. Penelitian ini menyimpulkan bahwa variabel profitabilitas berpengaruh terhadap audit delay pada perusahaan LQ-45 yang terdaftar di BEI tahun 2017-2020. Sedangkan likuiditas, leverage dan umur perusahaan tidak berpengaruh terhadap audit delay pada perusahaan LQ-45 yang terdaftar di BEI tahun 2017-2020. Secara simultan likuiditas, profitabilitas, leverage dan umur perusahaan berpengaruh terhadap audit delay pada perusahaan LQ-45 yang terdaftar di BEI tahun 2017-2020.