bluuebunny/crossref_metadata_2025 huggingface dataset:
The Korean Wave: From Global Consumption to Global Creation
Authors: Choi Hangsub
Published: November 2023

La vague coréenne, appelée "Hallyu", connaît une popularité croissante à l'échelle mondiale. Des groupes de K-pop tels que BTS et Blackpink jouissent d'un succès sans précédent. Les passionnés de K-pop à travers le monde ne se limitent plus à partager et découvrir la K-pop ; ils se sont désormais appropriés ce genre musical en créant leurs propres contenus K-pop par le biais de reprises de danse. Cet acte créatif est devenu un moyen d'établir des connexions entre les fans, permettant le partage de leurs sentiments et émotions, et donnant naissance à une « tribu postmoderne ».Les dramas et les films coréens sont aussi adaptés à l'international via un processus de licence, donnant lieu à de nouvelles formes de contenu culturel créatif. L'engagement global dans la création de webtoons coréens s'est amplifié, dépassant le simple acte de consommation. La contribution des artistes locaux à la création de contenus liés à la Hallyu est essentielle. Elle favorise non seulement le respect de diverses cultures, mais elle promeut aussi la compréhension interculturelle. En résumé, la Hallyu n'est plus seulement une vague de consommation culturelle, elle est devenue une plateforme de création culturelle partagée.
40 ans de reproduction médicalement assistée : une lecture anthropologique et féministe
Authors: Franklin Sarah , Gardey Delphine
Published: November 2023

Dans cet entretien, Sarah Franklin revient sur son itinéraire, proposant des pistes pour aborder les transformations intervenues dans le champ de la reproduction médicalement assistée depuis 40 ans. Avec des enquêtes sur la médecine régénérative, le clonage ou les marchés de tissus et services reproductifs, Sarah Franklin est une figure incontournable de l’analyse des mutations médicales et sociales contemporaines dans le champ de la reproduction et de la parenté. Elle situe son parcours dans le sillage des pionnières de la critique féministe de l’anthropologie culturelle, des techniques et des sciences : Marylin Strathern, Shulamith Firestone ou Donna Haraway. Elle pointe les enjeux politiques et scientifiques de l’usage des technologies de la reproduction et les transformations intervenues dans la définition de la parenté. Soulignant l’importance des droits conquis par les personnes LGBTQ+, elle interroge les limites de ces transformations mobilisant la question de la « justice reproductive ».
La PMA en France : une reproduction des inégalités de genre ?
Authors: Rozée Virginie , de La Rochebrochard Élise
Published: November 2023

La procréation médicalement assistée (PMA) entretient des relations complexes avec le genre : elle permet de s’affranchir des normes dominantes de genre tout en (re)produisant une reproduction stratifiée, et donc des inégalités de sexe, classe et race. En 2010, nous avions écrit un article sur la PMA en France dans lequel nous montrions que, dans la façon dont elle était encadrée, organisée et pratiquée, la PMA reflétait la norme procréative, et excluait donc toutes celles et ceux qui ne s’y conformaient pas. Qu’en est-il aujourd’hui, après la révision de la loi de bioéthique en 2021 ? À partir de nos différents travaux de recherche, nous montrons que la loi constitue une avancée car elle est plus inclusive mais que l’accès à la PMA reste calqué sur une représentation genrée du travail procréatif.
Vers une justice reproductive queer au cœur des bioéconomies transnationales
Authors: Mamo Laura
Published: November 2023

Cet article est consacré à l’expansion transnationale de la procréation médicalement assistée et pose la question des comportements responsables à adopter dans le contexte des bioéconomies du xxi e  siècle. Il s’intéresse plus précisément à la fois aux représentations attachées aux familles lesbiennes, gays, bisexuelles, transgenres et queers (LGBTQ+) et à la manière dont les personnes LGBTQ+ réalisent leurs projets parentaux dans les conditions actuelles. Cet article propose une grille d’analyse originale en l’espèce de la « justice reproductive queer  » (JRQ), laquelle doit permettre de saisir et de dire la variabilité des oppressions et opportunités à laquelle sont confrontées les différentes velléités de fonder une famille, sans pour autant ni diaboliser, ni valoriser certaines configurations familiales particulières. En somme, une telle approche doit aider à mettre en place des comportements responsables.
Early T Cell Infiltration Correlates with Anti-CTLA4 Treatment Response in Murine Cancer Models
Authors: Almonte Andrew A , Cavic George , Carroll Christina S E , Neeman Teresa , Fahrer Aude M
Published: November 2023

Immune checkpoint inhibitor (ICI) Abs are a revolutionary class of cancer treatment, but only ∼30% of patients receive a lasting benefit from therapy. Preclinical studies using animals from the same genetic backgrounds, challenged with the same cancer models, also show nonuniform responses. Most mouse studies that have evaluated tumor-infiltrating leukocytes after ICI therapy cannot directly correlate their findings with treatment outcomes, because terminal methods were used to acquire immune infiltrate data. In the present study, we used fine-needle aspiration (a nonterminal sampling method) to collect multiple aspirates over several days from s.c. implanted P815, CT26, and 4T1 mouse cancer models treated with ICI Abs. These aspirates were then analyzed with flow cytometry to directly correlate tumor-infiltrating leukocyte populations with treatment success. We found that the P815 and CT26 models respond well to anti-CTLA4 therapies. Among P815-challenged animals, mice that regressed following anti-CTLA4 treatment showed significant increases in CD8+ T cells on days 3, 5, and 7 and in CD4+ T cells on days 5 and 7 and a decrease in macrophages and monocytes on days 3, 5, and 7 after treatment. Similar results were obtained in the CT26 model on day 11 posttreatment. Our study is the first, to our knowledge, to directly correlate early tumor infiltration of T cells with anti-CTLA4 treatment success, thus providing a mechanistic clue toward understanding why alloidentical mice challenged with identical tumors do not respond uniformly to ICI therapies.
Oxidative Stress Induces E-Selectin Expression through Repression of Endothelial Transcription Factor ERG
Authors: Zhang Jinjin , Zhang Shuo , Xu Shanhu , Zhu Zhiying , Li Jiang , Wang Zengjin , Wada Youichiro , Gatt Alex , Liu Ju
Published: November 2023

Oxidative stress induces a prothrombotic state through enhancement of adhesion properties of the endothelium. E-selectin, an endothelial cell adhesion molecule, becomes a therapeutic target for venous thrombosis, whereas the regulatory mechanisms of its expression have not been fully understood. In the present study, we report that H2O2 treatment increases expression of E-selectin but decreases expression of the endothelial transcription factor ETS-related gene (ERG) in HUVECs in a dose- and time-dependent manner. In BALB/c mice treated with hypochlorous acid, E-selectin expression is increased and ERG expression is decreased in endothelial cells of the brain and lung. RNA interference of ERG upregulates E-selectin expression, whereas transfection of ERG-expressing plasmid downregulates E-selectin expression in HUVECs. Knockdown or overexpression of ERG comprises H2O2-induced E-selectin expression in HUVECs. Deletion of the Erg gene in mice results in embryonic lethality at embryonic days 10.5–12.5, and E-selectin expression is increased in the Erg−/− embryos. No chromatin loop was found on the E-selectin gene or its promoter region by capture high-throughput chromosome conformation capture. Chromatin immunoprecipitation and luciferase reporter assay determined that the −127 ERG binding motif mediates ERG-repressed E-selectin promoter activity. In addition, ERG decreases H2O2-induced monocyte adhesion. Together, ERG represses the E-selectin gene transcription and inhibits oxidative stress–induced endothelial cell adhesion.
Diverse Functions of C4b-Binding Protein in Health and Disease
Authors: Werner Lacie M , Criss Alison K
Published: November 2023

C4b-binding protein (C4BP) is a fluid-phase complement inhibitor that prevents uncontrolled activation of the classical and lectin complement pathways. As a complement inhibitor, C4BP also promotes apoptotic cell death and is hijacked by microbes and tumors for complement evasion. Although initially characterized for its role in complement inhibition, there is an emerging recognition that C4BP functions in a complement-independent manner to promote cell survival, protect against autoimmune damage, and modulate the virulence of microbial pathogens. In this Brief Review, we summarize the structure and functions of human C4BP, with a special focus on activities that extend beyond the canonical role of C4BP in complement inhibition.
A multidisciplinary approach of impacted and transposed maxillary canine: A case report
Authors: Iman Dimas , Narmada Ida B. , Yusuf Muchammad R. , Putri Ratna
Published: November 2023

The impacted and transposed teeth cause consequences in tooth eruption and movement, resulting in aesthetic and functional outcomes. A proper treatment plan with treatment duration and cost consideration is necessary to treat them. This study reported treatment for a 23-year-old male patient with impacted and transposed canine in maxilla using a multidisciplinary method between orthodontic and conservation. According to the anamnesis of the patient, his upper arch midline contained an extra tooth when he was a child. With the consideration of the duration and cost of treatment, the preferable and manageable treatment fell into the correction using a fixed orthodontic appliance with careful mechanics and enameloplasty to achieve the aesthetic and functional goal.
Observational study investigating the relationship between maxillomandibular characteristics and temporomandibular disc conditions in female patients with a skeletal class III pattern
Authors: Suntornchatchaweach Supakorn , Hoshi Kenji , Okamura Kazutoshi , Yoshiura Kazunori , Soonklang Kamonwan , Takahashi Ichiro
Published: November 2023

OBJECTIVES:

The objective of this study was to analyze the relationship between maxillomandibular characteristics and the severity of temporomandibular disc displacement in female patients with a skeletal class III (SKIII) pattern.

METHODS:

Fifty-seven samples were included in the study. The evaluation of articular disc conditions was conducted using magnetic resonance imaging, while 25 cephalometric variables from lateral and postero-anterior (P-A) cephalograms were measured to determine their maxillomandibular characteristics. The samples were categorized into three groups based on the articular disc conditions: (1) normal disc position (NDP), (2) disc displacement with reduction (DDwR), and (3) disc displacement without reduction (DDwoR). The relationship between the maxillomandibular characteristics and disc conditions was examined through both basic statistical analysis and multivariate analysis using principal component analysis (PCA).

RESULTS:

The Kruskal–Wallis and Dunn–Bonferroni tests revealed a significant difference between the groups in terms of the deviation of mandibular characteristics observed on the P-A cephalogram. The DDwoR group exhibited significantly larger menton deviation, ramal height asymmetry index, and total mandibular length asymmetry index compared to the NDP and DDwR groups. Moreover, the PCA successfully extracted all cephalometric variables into eight principal components. Among them, only the principal component related to mandibular asymmetry was able to differentiate the SKIII samples with DDwoR from the other groups.

CONCLUSIONS:

The findings of this study highlight a significant relationship between mandibular asymmetry and the severity of disc displacement, particularly DDwoR, in female patients with a SKIII pattern.
Knowledge, attitude, and practice regarding informed consent among dental professionals in Madina City, Saudi Arabia: A cross-sectional study
Authors: Koura Hussein , Al-Fraidi Ahmad A. , Alzemei Wasseem Abdulhameed
Published: November 2023

AIM:

The aim of this study was to assess the knowledge, attitude, and practice (KAP) of dental professionals regarding informed consent (IC) in Madina City.

METHODS:

A descriptive cross-sectional design using a self-administered questionnaire was conducted. The questionnaire was tested for validity and reliability before it was distributed using Google Forms through WhatsApp among a sample of 299 dental professionals working in Madina City. IBM Statistical Package for Social Sciences (SPSS) version 26 was used for analysis.

RESULTS:

Two-hundred ninety-nine responses were collected. Sixty percent scored less than the group average regarding knowledge, and 52% scored less than the group average regarding attitude. Regarding practice, 57% scored below the group average. Saudi dentists and those who work in the Ministry of Health (MOH) had better knowledge scores than other tested groups. Dentists working in the MOH had better attitude and practice scores than those who work in the private sector. Regarding attitude and practice, consultants achieved better scores than registrars and general dentists. More than 90% indicated that the main reason for obtaining an IC is to protect themselves from legal actions.

CONCLUSION:

The KAP of surveyed dental professionals in Madina is suboptimal and needs improvement.
Facial flow line and its effect on dental midline deviation on a female subject in an Asian population – A cross-sectional study
Authors: Maaz Muhammad , Tahir Kanza , Fida Mubassar , Sukhia Rashna H.
Published: November 2023

INTRODUCTION:

This study aims to understand the relationship between midline deviations and the inherent asymmetry that can be observed in a human face.

MATERIALS AND METHODS:

A cross-sectional study was conducted using a frontal smile photograph of a female which was altered on Adobe Photoshop software version 23.0 into eight different photographs by deviating the dental midlines by 2 mm, 4 mm, and 6 mm towards and away from the facial flow line (FFL). 4 mm of chin deviation was incorporated in all the pictures except for the first picture in which the midline and chin were kept symmetric. Orthodontic residents evaluated those photographs on an interrupted visual analogue scale (VAS) with 0 being the least attractive and 10 being the most. Simple linear regression was applied to observe factors associated with VAS score.

RESULTS:

Highest score was observed for picture with midline and chin on (MLCon) with a score of 9.4 ± 0.7, followed by picture with midline on and chin deviated (MLon) 8.7 ± 0.8. The deviations towards green zone received higher scores in comparison to deviations towards red zone. Linear regression revealed highly statistically significant differences between the constant and the rest of the pictures.

CONCLUSIONS:

The formation of green and red zones by the FFL influences the perception of midline deviation as judged by orthodontic residents. Midline when deviated towards the green zone, was judged to be more aesthetic than when shifted towards the red zones.
Routine preoperative screening computed tomography of the thorax for cardiac surgery
Authors: Sule Jai Ajitchandra , Chan Xue Wei , Sampath Hari Kumar , Luo Hai Dong , Ahmed Mofassel Uddin , Kang Giap Swee
Published: November 2023

Introduction:

This study aimed to evaluate the role of screening computed tomography (CT) of the thorax in cardiac surgery by analysing the presence of CT aortic calcifications in association with changes in operative strategy and postoperative stroke, and the CT features of emphysema with development of pneumonia.

Methods:

All patients who underwent cardiac surgery from January 2013 to October 2017 by a single surgeon were retrospectively studied. Patients who underwent screening CT thorax before cardiac surgery (CT group) were compared to those who did not (no CT group). Multivariate subgroup analyses were performed to determine significant association with postoperative outcomes.

Results:

A total of 392 patients were included, of which 156 patients underwent preoperative screening CT thorax. Patients in the CT group were older (63.9 vs. 59.0 years, P = 0.001), had fewer recent myocardial infarctions preoperatively (41% vs. 56.4%, P = 0.003) and had better ejection fraction (>30%; P = 0.02). Operative strategy was changed in 4.3% of patients, and 4.9% of patients suffered stroke postoperatively. The presence of CT aortic calcifications was significantly associated with change in operative strategy (P = 0.016) but not with postoperative stroke (P = 0.33). Age was an independent risk factor for change in operative strategy among patients with CT thorax (P = 0.02). Multivariate age-adjusted analysis showed only palpable plaque to be significantly associated with change in operative strategy (P < 0.001). None of the patients with CT emphysema features developed pneumonia.

Conclusion:

The results of this study do not support routine use of preoperative screening CT thorax. Contrasted CT may be advisable in older patients and for other operative planning purposes.
Elevated expression of Axin2 in intestinal metaplasia and gastric cancers
Authors: Lee Dong Hui , Jeong In Ho , Jang Bogun
Published: November 2023

Background: The Wnt signaling pathway regulates crucial cellular processes, including stem cell development and tissue repair. Dysregulation of this pathway, particularly β-catenin stabilization, is linked to colorectal carcinoma and other tumors. Axin2, a critical component in the pathway, plays a role in β-catenin regulation. This study examines Axin2 expression in normal gastric mucosa and various gastric pathologies.Methods: Formalin-fixed and paraffin-embedded tissue samples from normal stomach, gastritis, intestinal metaplasia (IM), and gastric carcinoma were collected. Axin2 and β-catenin expression were evaluated using RNA in situ hybridization and immunohistochemistry, respectively. Histo-scores (H-scores) were calculated to quantify expression levels of Axin2. Associations between Axin2 expression and clinicopathological variables were examined.Results: Axin2 expression was examined in normal stomach, gastritis, and IM tissues. Axin2 expression was mainly observed in the surface and isthmus areas in the normal stomach and gastritis, whereas Axin2 expression was markedly higher at the bases of IM. Axin2 H-scores were significantly elevated in IM (mean ± standard deviation [SD], 87.0 ± 38.9) compared to normal (mean ± SD, 18.0 ± 4.5) and gastritis tissues (mean ± SD, 33.0 ± 18.6). In total, 30% of gastric carcinomas showed higher Axin2 expression. Axin2 expression did not have significant associations with age, sex, Lauren classification, histological differentiation, invasion depth, and lymph node metastasis. However, a strong positive correlation was observed between Axin2 and nuclear β-catenin in gastric carcinomas (p < .001).Conclusions: Axin2 expression was significantly increased in IM compared to normal and gastritis cases. In addition, Axin2 showed a strong positive association with nuclear β-catenin expression in gastric carcinomas, demonstrating a close relationship with abnormal Wnt/β-catenin signaling pathway.
Comprehensive Profile of Pathogens and Antimicrobial Resistance in Conjunctivitis Cases from Niger
Authors: Amza Abdou , Nassirou Beido , Kadri Boubacar , Ali Saley , Mariama Boubacar , Ibrahim Cissé Mamadou , Roufaye Lamine Aboubacar , Lebas Elodie , Colby Emily , Zhong Lina , Chen Cindi , Ruder Kevin , Yu Danny , Liu YuHeng , Abraham Thomas , Chang Aaron , Mai Lina , Hinterwirth Armin , Seitzman Gerami D. , Lietman Thomas M. , Doan Thuy
Published: November 2023

Infectious conjunctivitis outbreaks remain a public health burden. This study focuses on the pathogen and antimicrobial resistance (AMR) profiles identified in Niger. Sixty-two patients with acute infectious conjunctivitis who presented to health posts were enrolled from December 2021 to May 2022. Nasal and conjunctival swabs were obtained from each patient. Unbiased RNA deep sequencing (RNA-seq) was used to identify associated pathogens. A pathogen was identified in 39 patients (63%; 95% CI, 50–74). Of those, an RNA virus was detected in 23 patients (59%; 95% CI, 43–73). RNA viruses were diverse and included human coronaviruses (HCoVs): SARS-CoV-2, HCoV-229E, HCoV-HKU1, and HCoV-OC43. A DNA virus was identified in 11 patients (28%; 95% CI, 17–44). Of those, four patients had a coinfection with an RNA virus and two patients had a coinfection with both an RNA virus and a bacterium. DNA viruses were predominantly human herpesvirus (cytomegalovirus, Epstein–Barr virus, human herpesvirus 8) and human adenovirus species B, C, and F. Eighteen patients (46%; 95% CI, 32–61) had a bacteria-associated infection that included Haemophilus influenza, Haemophilus aegyptius, Staphylococcus aureus, Streptococcus pneumoniae, and Moraxella spp. Antimicrobial resistance determinants were detected in either the conjunctiva or nasal samples of 20 patients (32%; 95% CI, 22–45) and were found to be more diverse in the nose (Shannon alpha diversity, 1.12 [95% CI, 1.05–1.26] versus 1.02 [95% CI, 1.00–1.05], P = 0.01). These results suggest the potential utility of leveraging RNA-seq to surveil pathogens and AMR for ocular infections.
Two truths in Buddhist philosophy
Authors: Thakchoe Sonam
Published: November 2023

Contemporary academic Buddhist philosophers are putting forward some tentative proposals to articulate the nature of the two truths in Buddhist philosophy and its relationship with Western philosophical theories of truth. Current philosophical studies reveal that the two truths in Buddhist thought are not in any way directly equivalent to any of the Western philosophical conceptions of truth. Even when approaching the two truths semantically, which is the predominant approach to truth in Western philosophy, the traditional Buddhist philosophers are not strict correspondence theorists and neither are they strictly coherentists. Nor are they pragmatists or realists, not even fictionalists or deflationary theorists in a strict Western philosophical sense. And yet, as we shall observe, the Buddhist notions of truth do share many aspects in common with Western philosophical treatments of truth.
Buddhist political theory
Authors: Moore Matthew J.
Published: November 2023

Buddhist political theory is normative thinking about politics from a Buddhist perspective. In other words, it is Buddhist ideas about what government should do and why [see Political philosophy]. Starting with the earliest records of the teachings of the Buddha, there are brief discussions about how governments should rule scattered throughout Buddhist texts. Until the mid-nineteenth century CE, almost all of these texts assume that government for laypeople will be an enlightened but absolute monarchy. Starting in the mid-to-late nineteenth century, in response to pressures and opportunities created by European colonialism, there was a fairly rapid move away from monarchy and toward various forms of democratic, or at least popular, government (sometimes more in name than in practice). Among contemporary Buddhists in many countries, there appears to be wide but not universal agreement that, to the extent Buddhism has any view on politics at all, it sees democracy as an acceptable, perhaps even preferred, system of government.

The Buddhist approach to political theory is quite different from other approaches, such as those from the Islamic, Confucian, Christian, or broadly Western traditions. The Buddhist approach appears to arise from a handful of key ideas: (1) that reducing suffering is the central concern of both individual existence and collective political action; (2) that suffering arises from a conflict between what one wants or expects and what life actually gives one; (3) that in most – but not all – cases changing one’s mind is easier and more fruitful than trying to change the world; (4) that acting based on desire will lead one to be reborn according to the fruits of one’s actions (the theory of kamma or karma); (5) and that, therefore, treating each other well is not only a kind or good thing to do, but is in everyone’s best self-interest.
Melodeklamacja, czyli pogranicza piosenki
Authors: Sokalska Małgorzata
Published: November 2023

Melodeclamation that is Borderlands of Song-Writing

The notions of melodeclamation and melorecitation are almost synonymous with the genre definition of a song understood as multi-code unity of textual and musical components, for which the appropriate existence form is an audio realisation. Meanwhile, a broader academic research on the phenomenon of melorecitation is lacking, aside from short dictionary descriptions as well as relatively recent connection with the performance style characteristic for rap music. It seems that only there the expression of recitation is treated as something inspiring in connection with the musical element, as in other styles and genres the recitation with music in the background has become synonymous with being kitschy, vocally unskilled and characteristic for school as well as amateur performances of poetry. However, the historical tradition of melodeclamation and the modern examples of introducing recitation and melorecitation to songs with high art aspirations encourage us to looks at such practices more closely. Melorecitation can become a more widely used artistic choice amongst the professional performers (actor song, poetry song) but also a unobvious experiment by the artists using other’s voices – of the poet reciting his own poems – in their own projects.
Niedośpiewana polityczność. O Toaście Agnieszki Osieckiej
Authors: Ratajczak Wojciech
Published: November 2023

Unsung Political Character. On Toast by Agnieszka Osiecka

The article discusses Agnieszka Osiecka’s poem Toast, found in manuscript only after the poet’s death. The author begins by looking at the strategies of functioning in the reality of communist Poland employed by the author of Biała bluzka (White Blouse). In particular, however, he draws attention to Osiecka’s reaction to the declaration of martial law as the main reason for her confronting the poem form. In the rest of the argument, the author interprets Toast, defining it – adopting the term proposed by Jacek Łukasiewicz – as a multi-voice, medium- sized poem with a lyrical dominance. He also looks at the linguistic side of the work, paying particular attention to the typical as well as different patterns used by the poet for the language of martial law poetry. In concluding, the author draws attention to the role that the very attempt to write the poem played in Osiecka’s correction of her creative technique so that the language of her songs was in line with the new socio-political reality of the 1980s.
(U)śmiechy kobiet. Komizm a emancypacja w piosenkach Agnieszki Osieckiej
Authors: Trybek Kamil
Published: November 2023

(Smiling) Laughter of a Woman. Comedy and Emancipation in the Songs of Agnieszka Osiecka

The article interprets the oeuvre of Agnieszka Osiecka in the context of communist aesthetics and the feminist theory. Analyzed were the songs Damą być (To Be a Lady), Nie ma jak pompa (There Is Nothing Like Splendour) oraz Sztuczny miód (Artificial Honey). The author recognises them as songs of emancipatory character. Research tools constructed by Bohdan Dziemidok were introduced and combined with the theses developed by Henri Bergson, while being focused on the communal dimension of laughter. Amongst all the feminist theoreticians, Hélène Cixous proved to be most inspiring. With their help the constructing methods used by the poet that support the emancipatory efforts of women fighting for their decision-making rights and independence during communist times were characterised. The analysis is supplemented by interpreting the performances of Osiecka’s songs as well as alluding to the theory from the area of song studies.
Analysis of the Educational Effects Regarding the Use of ChatGPT in Compulsory Basic Coding Subjects
Authors: Kim Wanseop
Published: November 2023

Computational thinking and basic coding education are recognized as essential competencies for living in the era of the 4th Industrial Revolution. Therefore, there has been a recent trend in universities to expand the number of required general education classes dealing with basic coding and AI data analysis. Computational thinking and coding are unfamiliar fields to college freshmen, so they often find these fields of study difficult. In addition, there is a large variation in class understanding depending on the student's elementary, middle, and high school learning background, making it difficult to administer the course as a required liberal arts course. To solve these problems, instructors can consider introducing the ChatGPT service, an AI-generated chatbot. In this study, the effectiveness of ChatGPT was analyzed by applying ChatGPT to some classes in the compulsory liberal arts subject in computational thinking at S University in Seoul. Out of a total of 75 classes, 7 classes included the use of ChatGPT in the curriculum and actively utilized it, while the remaining 68 classes used the existing general method. An end-of-semester student survey was conducted, and 966 students participated in the survey. Following this, a t-test was performed to compare the differences in satisfaction and perception between the two groups. As a result of the analysis, this study confirmed that the classes that actively used ChatGPT brought about a positive perception among the students in terms of their satisfaction with the course and their awareness of ChatGPT use. Moreover, this study confirmed a statistically significant difference between the students’ perception and satisfaction with this chatbot. The use of ChatGPT in basic coding has positive aspects, but on the other hand, it may have a negative effect on developing one's capabilities as students become dependent on AI chatbots. In the future, there is a need to develop and operate a more systematic ChatGPT application curriculum and to analyze its effectiveness.
A CRITICAL REVIEW ON KSHARA- DOSHA
Authors: Kaushik Sakshi , Gupta Ajay Kumar
Published: November 2023

In the context of Shalya Tantra, Acharya Sushruta, popularly known as ‘The Father of Indian Surgery’ has devised a number of surgical instruments and appliances for the ailments requiring some sort of minor or major surgeries. More importantly, in the cases that require Chhedana (incising), Bhedana (excising) and Lekhana (scraping), the concept of Kshara (alkalis or alkaline preparations) given by Acharya Sushruta is of great importance
than surgical instruments and appliances (both principal and secondary or substitutive); as they possess of the virtue of subduing the three deranged bodily humors namely Vata, Pitta and Kapha.
1These alkalis or alkaline preparations are termed as ‘Kshara’ based on their property of corroding (the skin or the flesh of an affected part of the
body), or on their peculiar quality in destroying the skin and flesh where such an effect is desired.2Besides numerating eight commendable good qualities of an alkali viz.,being Na ati tikshna (neither too strong) Na ati mridu
(nor too mild), Na ati shukla (white in colour), Shlakshna (smooth), Pichhila (slimy), Avishyandi (not spreading),
Shiva (stable), Shighra (acting well and quickly)3
; Acharya Sushruta has also mentioned its Dosha (adverse effects) which consist in its being Ati mridu (too mild), Ati shweta (of excessive whiteness), Ati ushna (excessive
heat producing), Ati tikshna (of excessive strength), Ati pichhila (of over- sliminess), Ati sarpita (greatly spreading), Ati sandra (excessive thickness), Apakva (not well cooked) and Hinadravya (lacking in drugs).4
CONCEPTUAL STUDY ON MANAGEMENT OF AGANTUJA VRANA
Authors: K Raksha , P John Elizabeth
Published: November 2023

Sadhyovrana was defined by ancient Indian surgeons as Vrana that occurs instantly or unexpectedly as a result of an assault or damage executed by humans, animals, or weapons. The wound has been classified as Nija and Agantuja vrana. Agantuja vrana is considered a traumatic wound. Sadhyovrana is a condition characterized by intense pain as a result of Vataprakopa associated with severe bleeding. The control of bleeding and the restora-tion of lost blood is the primary objective in the management of traumatic injuries, whereas Tridosha siddhanta, the basic principle of Ayurvedic medicine, is meant to balance the affected Vata Dosha in association with Rak-tastambhana. Sadyovrana explained by Acharya Sushrutha are of 6 types namely Chinna, Bhinna, Viddha, Kshata, Picchitha and Ghrishta. Description of its management is present in Sushrutha Samhita, Astanga San-graha and Astanga Hridaya.
SARVAKRIMINAM APAKARSHANAM EVADITAH KARYA
Authors: Mohantyc Bishnupriya , Vasant Naik Manaswi , Keshari Das Sangram
Published: November 2023

Krumi is an important disease mentioned in Ayurvedic science and is described in detail concerning its aetiology,
clinical features and treatment. The term Krumi is used to denote tiny organisms which reside in the human body.
The concept of Krumi and its relation to the development of disease is described in almost all Ayurvedic Samhitas. Acharyas also describes Krumi as an etiological factor in various diseases. Krumi contributes significantly
to the global burden of diseases. Overcrowding, contamination of water, and poor sanitation greatly favour transmission of parasitic infection resulting in high endemicity. Intestinal worm infestation results in impaired nutrition. Many neglect this condition as most of the time it may be asymptomatic. It may be associated with malnutrition, iron deficiency anaemia, repeated gastrointestinal disturbances and upper respiratory tract infections.
AYURVEDIC MANAGEMENT OF CHRONIC RHINOSINUSITIS (CRSsNP) - A CASE
REPORT
Authors: A R Remya , Mukhopadhyay B
Published: November 2023

Chronic rhinosinusitis (CRS) is a multifactorial inflammatory disease of nasal and paranasal mucosa presenting
with a variety of symptoms combinations. It is an inflammatory process that involves the paranasal sinuses and
persists for 12 weeks or longer. If not treated properly it can cause complications. A 36-year-old female patient
came to OPD, complaining of nasal obstruction, postnasal discharge and heaviness of head. The features suggestive
of chronic rhinosinusitis and CT PNS confirmed the diagnosis of right frontal and left maxillary sinusitis. The
patient was given Lakshmivilāsa rasa 250 mg bd and Pratimarşa Nasya with Shadbindu taila 3drops in each nostril
for one month. The patient became asymptomatic and there was no fluid accumulation or opacification in paranasal
sinuses after one month of treatment. Chronic rhinosinusitis (CRS) is characterized by prolonged mucosal inflammation of the nose and paranasal sinuses. This treatment is very cost effective and beneficial for reducing inflammation. Pratimarsa Nasya can be done daily without having many restrictions and can yield the benefits same as
that of Marsa Nasya.
MANAGEMENT OF RECURRENT PILONIDAL SINUS BY EXCISION FOLLOWED BY KSHARKARMA–A CASE REPORT
Authors: Kanthimath Kumar Siddayya , Thyagaraj C.
Published: November 2023

Background: Pilonidal sinus is a commonly encountered chronic suppurative condition leading to morbidity.
Seen dominantly in males, usually between the age group of 15 to 30 years. It presents acutely as an abscess and
in chronic condition intermittent pus discharge. Diagnosis usually with clinical and ultrasonography. Several operative procedures have been described to manage this condition. In the majority of cases, the treatment option is
surgical. Wide excision followed by primary or secondary intention of wound healing. Even after that, there is a
recurrence. In this article, I have treated recurrent pilo-nidal sinus by wide excision followed by kshara karma.
Now the wound is completely healed with no evidence of recurrence. Objective: Management of recurrent pilonidal sinus with chedana and Ksharakarma. Materials and methods: The subject presented with the complaint
of swelling, pain and pus discharge, Diagnosed as pilo-nidal sinus. The methodology adopted- is excision of the
sinus followed by kshara karma. Observed for signs of recurrence. Results: Clinically symptoms like pain, swelling, and pus discharge were completely reduced. On examination wound completely healed. No signs of reoccurrence. Conclusion: Adopted Ayurvedic treatment has given promising results in the management of recurrent
pilonidal sinus.
Modeling ion-π interactions of transition metal complexes
Authors:   University of Belgrade, Faculty of Chemistry, Serbia, Malenov Dušan P. , Ćeranić Katarina A. ,   Innovative center of the Faculty of Chemistry in Belgrade, Serbia, Vojislavljević-Vasilev Dubravka Z. ,   Innovative center of the Faculty of Chemistry in Belgrade, Serbia, Zarić Snežana D. ,   University of Belgrade, Faculty of Chemistry, Serbia
Published: November 2023

Interactions of π-systems with ions are very important for many chemical and biological systems. In this work we show how transition metal coordination strengthens cation-π interactions, and how it makes anion-π interactions of some systems possible. The calculations showed that cation-π interactions between ferrocene and alkali metal ions are stronger than cation-π interactions of benzene. The strongest cation-π interaction is between ferrocene and Li+, with interaction energy of -44.0 kcal/mol, while benzene-Li+ interaction has the energy of -36.1 kcal/mol. Cation-π interactions can also involve transition metal complexes as cations, with [Co(NH3)6] 3+/benzene interaction being very strong (-31.4 kcal/mol), while [Zn(H2O)6]2+/benzene interaction somewhat weaker (-14.0 kcal/mol). Anion-π interactions of unsubstituted aromatic rings without heteroatoms are possible if they are ligands in organometallic half-sandwich complexes with electron-withdrawing ligands. The anion-π interactions of such transition metal complexes with halides can reach the energy of -25.0 kcal/mol, and they are stronger than anion-π interactions of organic aromatic molecules.
Computer-aided design of new drugs against breast cancer
Authors:   University of Kragujevac, Faculty of Science, Kragujevac Center for Computational  Biochemistry, Department of Chemistry, Serbia, Mladenović Milan P. , Tomašević Nevena M. ,   University of Kragujevac, Faculty of Science, Kragujevac Center for Computational  Biochemistry, Department of Chemistry, Serbia, Matić Sanja Lj. ,   University of Kragujevac, Institute for Information Technologies, Serbia, Mladenović Tamara M. ,   University of Kragujevac, Institute for Information Technologies, Serbia, Ragno Rino ,   Sapienza University of Rome, Rome Center for Molecular Design, Department of Drug Chemistry and Technology, Italy
Published: November 2023

Computational medicinal chemistry, if used properly and in accordance with the available experimental data, may provide significant support to rational drug design. Herein, an overview of the computational approaches that have been applied to an estrogen receptor α (ERα) and endowed in the rational design of pM ERα antagonists with profound anti-breast cancer activity either in vitro or in vivo, will be presented. ERα is a 17β-estradiol inducible transcriptional regulator that initiates the RNA polymerase II-dependent transcriptional machinery, pointed for breast cancer (BC) development via either genomic direct or genomic indirect (i.e., tethered) pathway. To develop innovative ligands, structure-based (SB) 3-D QSAR, ComBinE, and 3-D Pharmacophore studies have been undertaken from experimentally resolved partial agonists, SERMs, and SERDs within either wild-type or mutated ERα receptors. SB and ligand-based (LB) alignments gave rules to align the untested compounds. The protocols led to the development of 3DQs, CBEs, and 3DPQs compounds, further synthesized and submitted to either in vitro or in vivo assessments, upon which new leads were revealed as candidates for clinical trials.
Workflow automation of high-throughput inverse docking using Pharmmapper
Authors:   University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Serbia, Alargić Aleksa P. , Levovnik Bojan D. ,   University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection,, Svirčev Miloš M. ,   University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection,
Published: November 2023

In this paper, we present a novel, modular script Pharmmapper-Mass-Docker for the inverse docking workflow automation based on the pharmacophore screening results obtained on the Pharmmapper server. Pharmmapper-Mass-Docker streamlines download, manipulation, and entire inverse docking of the Pharmmapper results, encompassing essential steps like ligand/gridbox/binding site coordinate extraction (via centroid generation) and obtaining the output data ready for further comprehensive data analysis. By automating the entire inverse docking procedure, our modular script potentially enhances data management efficiency during inverse docking and reverse screening, empowering the researchers to efficiently discover and explore novel protein-ligand interactions.
Green synthesis of chromeno-pyrimidine derivatives – Part I
Authors:   University of Kragujevac, Institute for Information Technologies, Serbia, Simijonović Dušica , Avdović Edina ,   University of Kragujevac, Institute for Information Technologies, Serbia, Milanović Žiko ,   University of Kragujevac, Institute for Information Technologies, Serbia, Milenković Dejan ,   University of Kragujevac, Institute for Information Technologies, Serbia, Marković Zoran ,   University of Kragujevac, Institute for Information Technologies, Serbia
Published: November 2023

Two different chromeno-pyrimidine derivatives were synthetized in the ionic liquid catalyzed reaction of barbituric acid and substituted salicylaldehydes. The product 5-(7-bromo-2,4-dioxo-1,3,4,5-tetrahydro-2H-chromeno[2,3-d]pyrimidin-5-yl)pyrimidine-2,4,6(1H,3H,5H)-tri-one (CP-1) was obtained in the reaction of barbiruric acid and 5-bromo-2-hydroxybenzaldehyde. The second new product 8,9-dihydroxy-2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione (CP-2) was yielded in the reaction between barbituric acid and 2,3,4-trihydroxybenzaldehyde. These products were isolated in moderate to good yield after 3h reflux in mixture of water: ethanol (1:1v/v) and in presence 20 mol% of catalyst – diethanolammonium chloroacetate. The structure of obtained products was confirmed using 1H NMR, 13C NMR, and IR spectroscopy methods.
Síndrome de Millard-Gubler en un paciente joven: diagnóstico y neurorrehabilitación temprana.
Authors: Arce-Gálvez Leonardo , Grisales-Gáfaro María Paz , Cantor-González Johan Fernando , Mancera-Álzate Juan Martin
Published: November 2023

Introducción: El Síndrome de Millard-Gubler (SMG) es una entidad neurológica poco frecuente que afecta el tronco encefálico por múltiples etiologías. El diagnóstico es clínico y requiere confirmación por estudios de imagen como la tomografía o la resonancia magnética. El tratamiento es generalmente no qu irúrgico con un enfoque rehabilitador con objetivos funcionales. Hallazgos clínicos: En este caso se presenta a un paciente masculino de 44 años del suroeste de Colombia, con antecedente de hipertensión arterial que ingresó al servicio de urgencias de un hospital universitario de referencia nacional con una emergencia hipertensiva y lesión de órgano blanco, presentó una perdida súbita de la movilidad de su hemicuerpo izquierdo acompañado del compromiso del VI y VII par craneal. Tratamiento y resultado: Se iniciaron intervenciones por un equipo multidisciplinario, incluyendo el servicio de rehabilitación, realizando el diagnóstico de un síndrome de tronco cerebral cruzado (Millard-Gubler) de etiología vascular hemorrágica. Requirió vigilancia en la UCIN hasta la estabilización de su condición clínica, posterior a lo cual se realizaron intervenciones de rehabilitación neurológica temprana (terapia física, terapia ocupacional, fonoaudiología, ortesis, psicología y dolor), logrando una mejoría de los síntomas y la funcionalidad del componente motor y cognitivo antes del alta hospitalaria. Conclusiones: Este caso refleja la importancia de un equipo multidisciplinar con un médico especialista en medicina física y rehabilitación para garantizar el mejor resultado funcional posible, además de reportar las intervenciones realizadas en un paciente joven con una entidad neurovascular poco frecuente.
Circunferencia del cuello y aterosclerosis subclínica.
Authors: Del Brutto Oscar H. , Rumbea Denisse A.
Published: November 2023

La circunferencia del cuello es un índice antropométrico recientemente introducido como predictor de enfermedades cardio y cerebrovasculares. Es un determinante de depósito de grasa subcutánea en la parte superior del cuerpo y un marcador de riesgo para el futuro desarrollo de enfermedad coronaria, fibrilación auricular y diabetes mellitus, entre otras condiciones. Además, se ha demostrado una relación directa entre circunferencia del cuello mayor de 40cm y aterosclerosis subclínica, especialmente a nivel cérvico-cefálico.
Dextra Tibia Fracture Resulting from a Traffic Accident
Authors:   Department of Forensic and Medicolegal Faculty of Medicine Universitas Sumatera Utara, Petrus Asan , Syahputra Novri ,   Department of Forensic and Medicolegal Faculty of Medicine Universitas Sumatera Utara
Published: November 2023

Background. By definition, blunt force trauma is a force that is caused by a blunt object on the surface of the body which results in injury. Blunt trauma can be caused by objects that have blunt surfaces such as stones, wood, hammers, fists and so on, which also includes falls from high places, traffic accidents and so on, which are currently increasing in severity. Case report. It was reported that a victim, initials N, was a pedestrian who was hit by a motorbike Results: on physical and radiological examination the victim suffered an open right tibial fracture. Conclusion. The female victim was involved in a traffic accident and suffered abrasions, lacerations and broken bones due to blunt trauma which required the victim to undergo treatment.
The Acceleration Model of Returning State Financial Losses Due to Corruption in Indonesia
Authors:   Department of Law, Sekolah Tinggi Hukum Bandung, Gunakaya Widiada , Januarsyah Mas Putra Zenno ,   Department of Law, Sekolah Tinggi Hukum Bandung
Published: November 2023

Recovery of state financial losses due to corruption is still an issue in Indonesia. Currently, this problem is resolved only through a conventional criminal justice process oriented towards punishment so that the recovery of state financial losses does not achieve maximum results. This study aims to analyze the appropriate model for accelerating the recovery of state losses due to corruption. This research is a juridical-philosophical research based on secondary data in the form of primary, secondary, and tertiary legal materials, using a statutory, philosophical, and conceptual approach. The data collection technique utilized a literature study and then analyzed qualitatively. This study concludes that a solution is needed as an alternative settlement of corruption cases through agreements based on the dual track system model of restorative justice, but constitutionally justified, according to legal theory, especially criminal law, and philosophically according to the theory of restorative justice. The solution is to accelerate the return of corrupt state finances through agreements with the restorative justice approach of the dual track system model, which is an effort based on democratic values, justice, benefit, fair legal certainty, and respect for the constitutional rights of the Indonesian people, aiming at people's welfare so that constitutionally not contrary to Article 1 paragraph (3) of the 1945 Constitution.