bluuebunny/crossref_metadata_2025 huggingface dataset:
COMPETITIVIDADE, CAPACIDADE DE INOVAÇÃO E DESENVOLVIMENTO REGIONAL: INTER-RELAÇÕES NO CONTEXTO DO AGRONEGÓCIO SUINÍCOLA NO OESTE DE SANTA CATARINA
Authors: Gianezini Miguelangelo , Saggin Kleiton Douglas , Brandão Fernanda S. , Winck César Augustus , Ruviaro Clandio Favarini , Leonardi Alex
Published: February 2019

O desenvolvimento regional é tema de debate nas esferas acadêmica, governamental e empresarial. E dentre os aspectos que influenciam nesta discussão estão a competitividade e a capacidade de inovação destes segmentos e das regiões. No Brasil, uma das prin
REDES DE BIOPROSPECÇÃO NO BRASIL: COOPERAÇÃO PARA O DESENVOLVIMENTO TECNOLÓGICO
Authors: Marques Lana Grasiela , Santos Maria Rita , Raffo Júlio , Pessoa Cláudia
Published: February 2019

A Bioprospecção se tornou uma das principais discussões nos últimos anos desde a Convenção sobre Diversidade Biológica (CDB), no entanto, as informações obtidas no banco de dados da Web of Science demonstraram que o estudo neste tema não se restringe aos
A AGRICULTURA FAMILIAR E A CADEIA PRODUTIVA DE ALIMENTOS ORGÂNICOS: CONQUISTAS
Authors: Fernandes Denise Medianeira Mariotti , Karnopp Erica
Published: February 2019

No contexto da agricultura familiar, contrapondo-se ao modelo de produção agrícola convencional, o modelo de produção orgânica vem conquistando novos adeptos. A agricultura orgânica propõe produzir alimentos saudáveis, com fundamentos na sustentabilidade,
AVALIAÇÃO DO PERFIL DO EMPREGO URBANO NO ESTADO DO CEARÁ: 1990 – 2010
Authors: SANTOS JOSÉ MÁRCIO DOS , JUSTO WELLINGTON RIBEIRO
Published: February 2019

O objetivo deste trabalho é analisar o comportamento do emprego urbano no Estado do Ceará. A partir da década de 1980 os Estados da Região Nordeste passaram a promover políticas de incentivo como forma de estimular a implementação e a descentralização das
A ELASTICIDADE PREÇO, SUBSTITUIÇÃO DE ALLEN, MORISHIMA E O RETORNO DE ESCALA DOS INSUMOS: UMA APLICAÇÃO DA FUNÇÃO CUSTO TRANSLOG NO SETOR AGROPECUÁRIO DOS MUNICÍPIOS DO SUBMÉDIO DO RIO SÂO FRANCISCO
Authors: Farias Tácito Augusto , Figueiredo Luiz Eduardo Nascimento , Araújo Ewerton Melo
Published: February 2019

Este trabalho teve como objetivo apresentar os conceitos de dualidade e função custo existentes na literatura, assim como apresentar um exemplo empírico utilizando a função custo translog para o cálculo das elasticidades-preço direta e cruzada, as elastic
O PAPEL FINANCEIRO NO DESENVOLVIMENTO REGIONAL
Authors: Carvalho Luciano Ferreira
Published: February 2019

Este estudo investiga as variáveis que afetam a concessão de crédito pelos bancos. A principal variável de interesse foi a Preferência pela Liquidez dos Bancos (PLB). A amostra é composta por cidades do estado de Minas gerais nos anos 2000, 2003, 2006 e 2
AS CIDADES MÉDIAS INTERIORIZADAS NO DESENVOLVIMENTO DO NORDESTE: UM ESTUDO SOBRE PAU DOS FERROS (RN)
Authors: Dantas Joseney Rodrigues de Queiroz , Clementino Maria Augusta do Livramento Miranda
Published: February 2019

Os estudos sobre as cidades médias no Brasil ganham destaque no meio acadêmico e na elaboração de políticas públicas nos anos 1970. Com o contexto econômico da globalização e as reconfigurações territoriais, alguns autores tem proposto a utilização do ter
GLOBALIZAÇÃO E FRAGMENTAÇÃO DO ESPAÇO AGRÁRIO EM RONDÔNIA
Authors: Silva Ricardo Gilson da Costa
Published: February 2019

O texto analisa os impactos do processo de globalização no espaço agrário do estado de Rondônia, elegendo como objeto o avanço do agronegócio da soja, que se constitui em um dos principais vetores das dinâmicas territoriais na Amazônia brasileira. A produ
A IMINÊNCIA DO DESENVOLVIMENTO DO SUL E O PAPEL DOS PAÍSES DO NORTE NESTES MERCADOS
Authors: Monteiro Marcelino Armindo , Corona Hieda Maria Pagliosa , Kischener Manoel Adir
Published: February 2019

Este trabalho aborda questões atuais de desenvolvimento nos países emergentes em particular nos países africanos, a luz dos modelos adotados e seus benefícios à população. Trata-se de analisar em que medida os modelos de desenvolvimento colonialistas do N
Capital social, desenvolvimento e planejamento regional: a participação da sociedade civil na região do coredes-fronteira oeste
Authors: Forgiarini Deivid Ilecki , Schroeder Christine da Silva , Cassanego Júnior Paulo Vanderlei , Alves Cínara Neumann
Published: February 2019

Com um processo desenfreado de globalização o nível local tem sido incapaz de responder com força frente aos novos desafios, em que pese a não descaracterização total, em prol
de uma massificação, que facilita o consumo, base deste sistema. Desde a “inve
A dinâmica de desenvolvimento em Lages e Joinville – Santa Catarina a partir de uma visão institucionalista neoschumpeteriana
Authors: Mondo Tiago Savi , Correio Gabriela Gonçalves Silveira Fiates , Correio Silvio Antônio Ferraz Cario
Published: February 2019

O desenvolvimento econômico é um processo de acumulação de capital e produtividade que leva a população à melhoria da qualidade de vida. Neste contexto, este artigo
objetiva comparar o desenvolvimento dos municípios de Lages e Joinville no Estado de Sant
Impacto na geração de emprego nos municípios do estado de sergipe decorrente do fator crédito : 2009 – 2012
Authors: Mendonça Priscila Jesus , Farias Tácito Augusto , Jorge Marco Antônio
Published: February 2019

O avanço empresarial e econômico fez com que as micro e pequenas empresas, necessitassem estar de acordo com o mercado global. E para isso são necessários recursos
financeiros. A fim de atender as demandas do mercado, estes recursos podem ser obtidos por
ESTUDO DE INDICADORES DAS PESQUISAS ACADÊMICAS EM BIOTECNOLOGIA NAS REGIÕES BRASILEIRAS: UMA VISÃO EM TORNO DA BIOECONOMIA
Authors: Rocha Angela Machado , Melro Maria Clara Barreto de Freitas , Santos Douglas Alves , Silva Marcelo Santana , Silva Maria Valesca Damásio de Carvalho
Published: February 2019

A Bioeconomia refere-se às atividades econômicas relacionadas com a criação, desenvolvimento, produção e uso de processos e produtos biológicos, em um universo onde a Biotecnologia é elemento primordial. Pela sua megabiodiversidade, fonte para imensurável
O ÍNDICE DE DIVERSIFICAÇÃO E O GRAU DE EXPOSIÇÃO AO MERCADO DOS AGRICULTORES PRODUTORES DE TABACO DA MICRORREGIÃO GEOGRÁFICA DE SANTA CRUZ DO SUL
Authors: Silveira Kathleen Rodrigues Krüger da , Machado Cidonea Deponti , Arend Silvio Cezar
Published: February 2019

Este estudo teve como objetivo analisar o processo de diversificação produtiva da Microrregião Geográfica de Santa Cruz do Sul dos agricultores associados à Associação de
Fumicultores do Brasil (AFUBRA). Para tanto, analisou-se o grau de exposição ao mer
DA ILHA DE PROSPERIDADE AO MAR DE TURBULÊNCIA: UMA ANÁLISE DO PROCESSO DE ENDIVIDAMENTO EXTERNO DO REGIME MILITAR (1968-1979)
Authors: Salomão Ivan Colangelo
Published: February 2019

O robusto crescimento econômico verificado nos anos 1970 esteve fortemente baseado no aumento expressivo do endividamento externo. Apoiado na alta liquidez internacional e nos “petrodólares”, os tecnocratas do regime militar adotaram uma estratégia de des
BANCOS PÚBLICOS E DESENVOLVIMENTO ECONÔMICO: A EXPERIÊNCIA DE BRASIL E CORÉIA DO SUL
Authors: Belieiro Junior José Carlos Martines , Muratt Bernardo Schirmer
Published: February 2019

O debate acadêmico sobre o desenvolvimento econômico dos países periféricos reconhece o papel positivo do Estado no fomento e apoio direto à industrialização. No caso de países como Brasil e Coréia do Sul, que vivenciaram experiência de rápida modernizaçã
ACESSO A SERVIÇOS EDUCACIONAIS E A LOCALIZAÇÃO DAS INSTITUIÇÕES DE ENSINO SUPERIOR PRIVADAS PRESENCIAIS NO ESTADO DE SERGIPE
Authors: Santos Ihanmarck Damasceno dos
Published: February 2019

A expansão das matrículas como resposta a demanda e percepção da educação superior como vetor de mobilidade social, contribuiu parcialmente para elevação do IDHM e redução de desigualdade de renda no País nos últimos anos. Este artigo faz uma abordagem en
REPERCUSSÕES DO USO DO AGROTÓXICO SISTÊMICO NA CULTURA IRRIGADA DO COCO NO POLO JUAZEIRO/ PETROLINA
Authors: Lima Júnior Ednêi Couto de , Souza Regina Celeste de Almeida
Published: February 2019

Norteada pela problemática dos impactos gerados na cadeia produtiva do coco, pelo uso de agrotóxicos, em especial o sistêmico, a pesquisa utiliza-se de material bibliográfico,
entrevistas e pesquisa de campo para levantar informações pertinentes e, busca
A COMPLEXIDADE TERRITORIAL DO CANYON DO RIO SÃO FRANCISCO E SUAS VÁRIAS INSTÂNCIAS DE GOVERNANÇA PARA O TURISMO
Authors: Cordeiro Tiago Sá Teles , Souza Regina Celeste de Almeida
Published: February 2019

O presente artigo decorre de estudos sobre a área do Canyon do rio São Francisco, destino turístico regional consolidado, no qual confluem três territórios político-administrativos estaduais. Debruçamo-nos em fazer uma reflexão sobre o conflito territoria
PAREDE MÁGICA: SENSIBILIZANDO E ECOLOGIZANDO O AMBIENTE NO CONTEXTO ESCOLAR
Authors: Marinho Isabel Cristina Alves
Published: February 2019

Ações de vandalismo são a cada dia mais recorrentes nas cidades brasileiras. Um agrupamento de práticas agressivas contra o patrimônio físico, que desencadeia transtornos ao ambiente e danos de cunho sociocultural, educacional e financeiro. Prognostica-se
UMA ANÁLISE MULTIDIMENSIONAL DO PROCESSO DE INTERNACIONALIZAÇÃO DE EMPRESAS SUL COREANAS NA AMÉRICA LATINA E O CASO KIA-MÉXICO
Authors: Pereira Ítalo Rodrigues , Oliveira Gustavo Henrique Alves de
Published: February 2019

Este artigo tem como objetivo descrever e analisar de forma multidimensional os fatores econômicos, políticos e estratégicos que serviram como forças motrizes dos eventos
relacionados à internacionalização de empresas sul coreanas na América Latina. Além
DESEMPENHO DA BALANÇA COMERCIAL BRASILEIRA DA CARNE BOVINA E DE FRANGO ENTRE 2000 E 2015
Authors: Gobi José Rodrigo , Paschoalino Pietro André Telatin , Alves Alexandre Florindo
Published: February 2019

Este trabalho verificou a influência da renda interna e externa, taxa de câmbio e abertura comercial sobre o comportamento dos saldos comerciais de carne bovina e de frango para o Brasil no período 2000-2015. Devido à existência de um vetor de cointegraçã
MOBILIDADE PARA TRABALHO NA REGIÃO METROPOLITANA DE SALVADOR: PONTOS PARA DEBATE
Authors: Dias Patricia Chame
Published: February 2019

Entendendo-se que, no capitalismo, o trabalho se converte em mercadoria e que o deslocamento de trabalhadores está relacionado à reprodução do capital, neste texto são discutidas algumas características e consequências da mobilidade da força de trabalho e
O DESAFIO DA INOVAÇÃO TECNOLÓGICA DENTRO DA UNIVERSIDADE
Authors: Miranda João Irineu de Rezende , Sidulovicz Nayara , Machado Daiani Martins
Published: February 2019

Este trabalho versa sobre o papel das universidades públicas brasileiras em pesquisa e desenvolvimento, como elemento de inovação tecnológica e indutoras do desenvolvimento social e econômico. Partindo dos dados referentes à pesquisa, desenvolvimento e in
ANÁLISE DA CADEIA PRODUTIVA DE UMA COMUNIDADE DE PESCADORES NO SUL DA BAHIA VISANDO O SEU DESENVOLVIMENTO ECONÔMICO
Authors: Behrmann Daianne Gabrielle Morais
Published: February 2019

O presente artigo tem como principal objetivo caracterizar os elos de produção e comercialização da cadeia produtiva da pesca artesanal, sob a ótica dos pescadores. Foram
utilizados dados de origem primária e secundária. Os dados primários foram levantad
A ECONOMIA POLÍTICA DA REINDUSTRIALIZAÇÃO SUSTENTÁVEL NO BRASIL: DIRECIONAMENTOS NECESSÁRIOS PARA UM DESENVOLVIMENTISMO AMBIENTAL
Authors: Portugal Júnior Pedro dos Santos , Reydon Bastiaan Philip , Portugal Nilton dos Santos , Vivaldi Guilherme Augusto Dionísio , Silva Sheldon William
Published: February 2019

O presente artigo tem por principal objetivo apresentar os principais direcionamentos para a implantação da reindustrialização sustentável no Brasil, buscando uma convergência para o que se pode denominar de desenvolvimentismo ambiental, ou seja, aliar ne
GOVERNANÇA DAS ÁGUAS NA BAHIA: UMA AVALIAÇÃO DA PARTICIPAÇÃO SOCIAL NO COMITÊ DE BACIA DO RECÔNCAVO NORTE E INHAMBUPE
Authors: Nunes Elizabete Almeida , Fadul Elvia , Cerqueira Lucas Santos
Published: February 2019

Desde promulgação da Constituição Federal de 1988, os movimentos sociais e outros segmentos da sociedade excluídos do processo decisório do Estado vêm reivindicando mais espaço e mais envolvimento político. Na governança das águas não é diferente, princip
REDUCCIÓN DEL GAP TECNOLÓGICO DE BRASIL EN EL DESARROLLO DEL MÍSSIL A-DARTER CON ÁFRICA DEL SUR
Authors: Costa Rogério Santos da , Fernandez Felipe , Vieira Nathany Fernanda Tavares
Published: February 2019

El artículo aborda la reducción del gap tecnológico en Brasil, en su programa misiles Aire-Aire a partir de la colaboración con Sudáfrica del programa A-Darter. Tuvo como objetivo conocer el encuadramiento generacional del misil A-Darter en relación a los
DISTRIBUIÇÃO DA OFERTA DOS SERVIÇOS PÚBLICOS DE SAÚDE NOS MUNICÍPIOS BRASILEIROS (2007-2014)
Authors: Afonso Damares Lopes , Perobelli Fernando Salgueiro
Published: February 2019

Este trabalho analisa a distribuição dos serviços públicos de saúde nos municípios brasileiros no período de 2007-2014. Os serviços públicos de saúde são avaliados no âmbito da prevenção e tratamento de doenças, através da análise da atenção à saúde prest
MERCADO MUNDIAL DO AÇÚCAR: UM ESTUDO DA COMPETITIVIDADE E DO GRAU DE CONCENTRAÇÃO DOS MERCADOS BRASILEIROS E TAILANDÊS (2000-2016)
Authors: Copetti Leonardo Sangoi , Fries Carol Deitos , Coronel Daniel Arruda
Published: February 2019

O objetivo deste estudo foi o de analisar a competitividade das exportações brasileiras no mercado mundial do açúcar, em 2000 e em 2016, em comparação ao quarto maior produtor e segundo exportador mundial, a Tailândia, e o grau de concentração das exporta
RELAÇÕES BRASIL-CHINA: UMA PARCERIA PARA DESENVOLVIMENTO OU UMA RELAÇÃO DE CODEPENDÊNCIA?
Authors: Moraes Isaías Albertin de , Aguiar Mônica Heinzelmann Portella de , Tauil Carlos Eduardo
Published: February 2019

Este artigo visa analisar as relações econômicas entre Brasil e China na contemporaneidade. A primeira parte da pesquisa aborda a Teoria da Dependência e sua interpretação das relações entre países periféricos e centrais no complexo sistema internacional.
CRIME E PLANEJAMENTO URBANO DE BAIRROS: O CASO DA MATA ESCURA NA METRÓPOLE BAIANA
Authors: Marx Carlos Augusto A. , Siqueira Leonardo M. L. C. de , Reis Renato B. , Souza Laumar N. de
Published: February 2019

Este artigo visa identificar elementos contributivos ao planejamento urbano na área da segurança pública a partir da análise das ocorrências de homicídios e suas formas tentadas em um bairro de baixa renda da metrópole baiana. O estudo considera na sua re
PANORAMA DA ESTRUTURA CIENTÍFICA E TECNOLÓGICA DE INOVAÇÃO DO ESTADO DO PARANÁ
Authors: Sartori Rejane , Machado Hilka Pelizza Vier , Capelete Ana Carolina Barbosa , Buzeti Luiz Claudio , Silva Douglas Rós da
Published: February 2019

Esta pesquisa teve como objetivo caracterizar a estrutura do sistema de inovação do Estado do Paraná, especificamente nas dimensões científica, tecnológica e de intermediação. Para tanto, foi realizada uma pesquisa de campo exploratória, a qual proporcion
EMIGRAÇÃO E IMOBILIDADE NO NORDESTE BRASILEIRO: ADAPTAÇÃO OU RESISTÊNCIA?
Authors: Correia Isac Alves , Ojima Ricardo
Published: February 2019

O Nordeste foi marcado durante décadas por intensos fluxos migratórios com destino especialmente ao Sudeste. Esses fluxos, que foram mais acentuados entre as décadas de
1950-1970, são interpretados pela literatura como uma resposta à seca ou aos diferenc
DESIGUALDADE REGIONAL E ESTRUTURA PRODUTIVA DO CENTRO-OESTE BRASILEIRO: UMA ANÁLISE PARA O PERÍODO 2005-2015
Authors: Silva Libania Araújo , Silva Lizandra Duarte da , Couto Felipe Mascarenhas
Published: February 2019

O Centro-Oeste brasileiro trata-se de uma região que teve sua ocupação e avanço socioeconômico relacionado principalmente ao desenvolvimento do setor agropecuário e a
instalação do principal núcleo político e administrativo do país em seu território. Des
CONSIDERAÇÕES SOBRE O EMPREENDEDORISMO COMO ELEMENTO PROPULSOR DO TURISMO NO BAIXO SÃO FRANCISCO
Authors: Silva Paulo Henrique Oliveira , Fonseca Débora Lomba Pinto , Spinola Carolina de Andrade
Published: February 2019

Para o pleno desenvolvimento turístico de uma região são necessárias ações empreendedoras que diversifiquem a base de serviços ofertados, amplifiquem o efeito multiplicador dos gastos dos visitantes e contribuam para um maior protagonismo da comunidade en
ENERGIA SOLAR EM JUAZEIRO/BAHIA: ROTAS E ALTERNATIVAS PARA OS CONDOMÍNIOS PRAIA DO RODEADOURO E MORADA DO SALITRE
Authors: Cunha Felipe Barroco Fontes , Mousinho Maria Cândida Arrais de Miranda , Torres Ednildo Andrade , Silva Marcelo Santana , Castro Celso Luiz Braga de
Published: February 2019

O presente trabalho visa analisar o programa autorizado pela Resolução ANEEL n. 4.385/2013 e a regulação nacional, em especial à afeta a geração distribuída, para propor rotas e alternativas que possam viabilizar a reconexão dos Condomínios Praia do Rodea
GESTÃO DE RESÍDUOS SÓLIDOS NO BAIXO SÃO FRANCISCO: A INICIATIVA DO ESTADO ALAGOANO
Authors: Jesus Daniele Balbino Moura de , Silva Patrick Passinho , Almeida Raissa da Matta , Reis Renato Barbosa
Published: February 2019

O avanço da urbanização nas cidades modernas e o aumento do consumo de bens, intensificou a produção de resíduos sólidos e com ela a preocupação com a disposição final destes. A fim de reduzir os impactos causados pela acomodação irregular destes resíduos
Urbanisation and water insecurity in the Hindu Kush Himalaya: Insights from Bangladesh, India, Nepal and Pakistan
Authors: Singh Sreoshi , Tanvir Hassan S. M. , Hassan Masooma , Bharti Neha
Published: February 2019

This paper reviews the interlinkages of critical state of water resources, supply systems, rapid urbanisation and demand regime, aggravated by tourism leading to increasing water insecurity in the Hindu Kush Himalaya (HKH). Urban centres in the HKH have been defined based on different criteria, but mountain-specific criteria are lacking. In the mountains, small settlements such as district headquarters perform a large number of functions, typical of an urban centre. However, they are not formally classified as urban centres because they do not meet the census-defined nationally set criteria of the respective country. Nonetheless, water insecurity is a reality, attributed to: (i) water governance issues; (ii) inappropriate urban planning, failing, and to some extent, unable to account for the floating population, such as tourists; and (iii) the scourge of climate change which could worsen the situation further. Short-term coping strategies to meeting water demands often involve unsustainable solutions, such as groundwater extraction, with long-term repercussions. However, long-term strategies for water sustainability by the governments have been beneficial while others are yet to show success. Initiatives by civil society and governments along similar lines in other countries could lead to a water-secure future for the fragile urban centres of the HKH region.
Pilot study of a horizontal roughing filtration system treating greywater generated from a peri-urban community in Durban, South Africa
Authors: Bakare B. F. , Mtsweni S. , Rathilal S.
Published: February 2019

There is a growing pressure on the available freshwater resources in South Africa and many other countries around the world. This has led to a large scale of interest in the application of water reclamation and reuse of wastewater as alternative water supply sources. This is becoming critical to sustain development and economic growth in the southern Africa region. This study investigated the performance of a horizontal roughing filtration system treating greywater generated from a peri-urban settlement in Durban, South Africa. The horizontal roughing filtration system consists of three compartments containing different sizes of gravels that serve as the filter media. The horizontal roughing filter was operated at a filtration rate of 0.3 m/hr for 90 days. The results indicated that at this low filtration rate, effective reduction in turbidity, conductivity, chemical oxygen demand and total solids can be achieved. Overall average removal efficiencies of 90% turbidity, 70% chemical oxygen demand, 86% conductivity, and 84% total solids were obtained for the entire duration of operation of the horizontal roughing filtration system. Thus, it was concluded that the horizontal roughing filtration system is suitable for the treatment of greywater for non-potable reuse applications although further investigation needs to be conducted for the microbial removal during the treatment.
Valorization of Crude Glycerol, Residue Deriving from Biodiesel- Production Process, with the Use of Wild-type New Isolated Yarrowia lipolytica Strains: Production of Metabolites with Pharmaceutical and Biotechnological Interest
Authors: Sarris Dimitris , Sampani Zoe , Rapti Anna , Papanikolaou Seraphim
Published: February 2019

Background & Objective:

Crude glycerol (Glol), used as substrate for screening eleven natural Yarrowia lipolytica strains in shake-flask experiments. Aim of this study was to assess the ability of the screened strains to produce biomass (dry cell weight; X), lipid (L), citric acid (Cit), mannitol (Man), arabitol (Ara) and erythritol (Ery), compounds presenting pharmaceutical and biotechnological interest, in glycerol-based nitrogen-limited media, in which initial glycerol concentration had been adjusted to 40 g/L.

Methods:

Citric acid may find use in biomedical engineering (i.e. drug delivery, tissue engineering, bioimaging, orthopedics, medical device coating, wound dressings). Polyols are considered as compounds with non-cariogenic and less calorigenic properties as also with low insulin-mediated response. Microbial lipids containing polyunsaturated fatty acids (PUFA) are medically and dietetically important (selective pharmaceutical and anticancer properties, aid fetal brain development, the sight function of the eye, hormonal balance and the cardio-vascular system, prevent reasons leading to type-2 diabetes, present healing and anti-inflammatory effects).

Results:

All strains presented satisfactory microbial growth (Xmax=5.34-6.26 g/L) and almost complete substrate uptake. The principal metabolic product was citric acid (Citmax=8.5-31.7 g/L). Production of cellular lipid reached the values of 0.33-0.84 g/L. Polyols were also synthesized as strain dependent compounds (Manmax=2.8-6.1 g/L, Aramax ~2.0 g/L, Erymax= 0.5-3.8 g/L). The selected Y. lipolytica strain ACA-DC 5029 presented satisfactory growth along with synthesis of citric acid and polyols, thus, was further grown on media presenting an increased concentration of Glol~75 g/L. Biomass, lipid and citric acid production presented significant enhancement (Xmax=11.80 g/L, Lmax=1.26 g/L, Citmax=30.8 g/L), but conversion yield of citric acid produced per glycerol consumed was decreased compared to screening trials. Erythritol secretion (Erymax=15.6 g/L) was highly favored, suggesting a shift of yeast metabolism from citric acid accumulation towards erythritol production. Maximum endopolysaccharides (IPS) concentration was 4.04 g/L with yield in dry weight 34.2 % w/w.

Conclusion:

Y. lipolytica strain ACA-YC 5029 can be considered as a satisfactory candidate grown in high concentrations of crude glycerol to produce added-value compounds that interest pharmaceutical and biotechnology industries.
In Silico Design, Synthesis of Hybrid Combinations: Quercetin Based MAO Inhibitors with Antioxidant Potential
Authors: Dhiman Priyanka , Malik Neelam , Khatkar Anurag
Published: February 2019

Background: Monoamine oxidase (MAO) is a critical target used for the cure of neuropsychological
diseases.

Objective: A series of quercetin based derivatives was designed, synthesized, and evaluated as novel
multifunctional agents against monoamine oxidase A and B with antioxidant potential.

Methods:

Hybrid derivatives based on quercetin were synthesized and screened for hMAO inhibition
along with antioxidant activity. Molecular docking was performed to explicate the rationale of the different
MAO (IC50) values and to explain the presence of inhibitory activity against specificity, respectively.

Results:

The results of in vitro hMAO inhibition showed that compound 8a, 6c, and 4 were found as
potent hMAO-A inhibitors whereas compounds 6b, 6a, and 6d were observed as potent hMAO-B inhibitors.
The DPPH radical scavenging activity showed that compounds 6b, 6a, and 4 exhibited a promising
antioxidant potential with IC50 values 5.931±0.007, 6.421±0.037, and 8.516±0.098 respectively.
Moreover, the compound 6b, 6a, and 4 exhibited remarkable H2O2 scavenging potential with IC50 values
05.80±0.004 µM, 06.20±0.009 µM, and 07.66±0.009 µM respectively.

Conclusion:

The results of docking studies were found in good correlation with experimental MAO inhibition
studies. Moreover, the mechanistic insight into the docking poses was also explored by binding
interactions of quercetin based derivatives inside the dynamic site of hMAO-A and hMAO-B. It was
also noticed that the potent MAO inhibitors were also acting as better antioxidants as evaluated through
DPPH radical scavenging activity and H2O2 radical scavenging assay.
Modular Synthesis of New Bicyclic Carbene Precursors
Authors: Li Jie , Yao Jiaqi , He Weiping , Yang Fan , Liu Xiaoming
Published: February 2019

:

A series of new N-heterocyclic carbene (NHC) precursors, containing bicyclic pyrrolo[1,2-
c]imidazole framework, were prepared from N-(tert-butoxycarbonyl)-L-proline (1-Boc-L-proline). The
sequential attachment of nitrogen nucleophiles and subsequent ring closure gave the desired bicyclic
NHC precursors in good yields. The structures of these new NHC precursors were determined on the
basis of spectroscopic techniques, including NMR and MS.
Comparing the Efficacy of Supervised and Unsupervised Exercise Training on Glycaemic Control in Type 2 Diabetes: A Systematic Review
Authors: Gajanand Trishan , Keating Shelley E. , Brown Wendy J. , Hordern Matthew D. , Fassett Robert G. , Coombes Jeff S.
Published: February 2019

Background:

Exercise training is vital for glycaemic control in patients with type 2 diabetes
mellitus (T2D). While the positive effects of supervised exercise training are well established,
unsupervised training may offer an alternative and more sustainable means of realising the benefits of
exercise away from a resource-heavy supervised setting.

Objective:

To evaluate the available literature and compare the efficacy of supervised and unsupervised
exercise training programs on glycemic control in patients with T2D.

Methods:

CINAHL, MEDLINE, PubMed, and EMBASE, searched from inception to 20 July 2018. Only
studies that included both supervised and unsupervised training were included.

Results:

Four studies, involving 115 participants, were included. One compared supervised with unsupervised
exercise training and three investigated the efficacy of unsupervised training following supervised
training. While supervised training is effective for improving glycaemic control in patients with
T2D, unsupervised training may not maintain these changes. Included studies lacked detail relating to
the supervised and unsupervised training programs.

Conclusion:

Given that exercise is a critical component for maintenance of glycaemic control in patients
with T2D, and because unsupervised training has been shown to be effective in improving clinical
outcomes in other disease populations, further research is warranted to compare supervised and unsupervised
exercise training in patients with T2D. It is important that future studies report standardised
and detailed descriptions of key elements that form the basis of supervised and unsupervised exercise
training groups.
Primary Prevention of Cardiovascular Risk in Octogenarians by Risk Factors Control
Authors: Palmiero Pasquale , Zito Annapaola , Maiello Maria , Cecere Annagrazia , Mattioli Anna Vittoria , Pedrinelli Roberto , Scicchitano Pietro , Ciccone Marco Matteo
Published: February 2019

Primary prevention of cardiovascular events in older adults is a relevant problem, due to lack of evidence for safe and efficacious therapy, its costs and elderly quality of life, Italy’s aging population is constantly increasing, so cardiovascular disease (CVD) primary prevention in the elderly is a prime objective. Life expectancy has dramatically increased over the last 2 decades, the proportion of individuals aged 80 years and older has grown rapidly in Europe and the United States, but cost / effective ratio of CVD prevention through risk factors control is debated. It is therefore important to implement cardiovascular risk factors estimation in the elderly to maximize the quality of life of patients and to lengthen their healthy life expectancy, choosing the better treatment for each patient sharing the choice with himself when it is possible, always remembering that elderly patients often have multiple co-morbidities that require a high number of concurrent medications; this may increase the risk for drug-drug interactions, thereby reducing the potential benefits of CVD prevention therapy. Nevertheless, CVD is not an inevitable concomitant of aging. Sometimes, autopsy in the elderly reveals atheroma-free coronary arteries, a normal-sized heart and unscarred valves. All primary prevention strategy decisions should consider estimated life expectancy and overall function and not just the cardiovascular event risks, magnitude and time to benefit or harm, potentially altered adverse effect profiles, and informed patient preferences. CVD primary prevention needs to be more implemented in the elderly, this might contribute to improve health status and quality of life in this growing population if correctly performed.
Cytotoxicity, Pro-apoptotic Activity and in silico Studies of Dithiocarbamates and their Structure Based Design and SAR Studies
Authors: Hamdani Syeda S. , Khan Bilal A. , Hameed Shahid , Rashid Faisal , Zaib Sumera , Ahmad Khalil , Mughal Ehsan U. , Iqbal Jamshed
Published: February 2019

Background:

Cancer is a far-reaching and lethal but curable disease. Researchers have
investigated numerous anticancer agents with only a few commercially available effective drugs
which are very costly.

Objective:

Herein, we report the synthesis , characterization and anti cancer assays of a series of
novel dithiocarbamates derivatives.

Methods:

All compounds were synthesized from different secondary amines and substituted benzyl
chlorides in a single step. The structures of newly synthesized dithiocarbamate derivatives
were confirmed by spectroscopic techniques (IR, NMR and HR-MS).

Results:

The synthesized compounds showed a significant anti-proliferative effect in cancer cells
(HeLa) with the maximum inhibitory activity of compound SHD-2 with an IC50 = 0.31 ± 0.09 μM.
However, the same compound exhibited 19.2% inhibition towards Baby Hamster Kidney fibroblasts
(BHK-21), normal cell lines. Moreover, quantification of cellular DNA by flow cytometry
for the evaluation of pro-apoptotic activity in HeLa cells demonstrates that arrest in cell cycle
along with apoptosis advance towards drug cytotoxicity. However, molecular docking studies of
the potent compound suggested that it binds to the major groove of the DNA.

Conclusion:

The cytotoxic and pro-apoptotic potential of the potent inhibitor may be further investigated
in the animal models to advance their anti-cancer prospective.
Ex Vivo and In Vivo Evidence of Anti-Inflammatory Activity of P-aminophenol and Salicylate Derivatives
Authors: Vilvert André F. , Nascimento Marcus Vinícius P.S. , dos S. Borges Rosivaldo , Dalmarco Eduardo M.
Published: February 2019

Background:

Paracetamol (p-aminophenol) and salicylates are nonsteroidal antiinflammatory drugs that are widely used in the general population. The adverse effects of both drugs continue to be a focus of the pharmaceutical industry in the development of new molecules that will increase treatment safety. In this context, we tested nine compounds derived from paracetamol and salicylates, synthesized in our laboratory, for their safety and ex vivo and in vivo anti-inflammatory activity.

Methods:

We analyzed the cytotoxicity of the compounds in ex vivo mice neutrophils, and their ability to inhibit the production of pro-inflammatory mediators (nitric oxide and interleukin-6) after stimulating with LPS. Next, in the selected molecules, we evaluated the anti-inflammatory effect on an in vivo inflammatory model of acute lung injury in mice. All nine compounds were also submitted to the cytotoxicity assay, like the original compounds.

Results:

None of the compounds showed cytotoxicity under the cells used. However, of the initial compounds, only five demonstrated anti-inflammatory effect, inhibiting Nitric Oxide (NO) and interleukin 6 (IL-6) production by neutrophils stimulated with Lipopolysaccharide (LPS). After this initial trial, four modified compounds were able to reduce leukocyte migration and fluid leakage in the bronchoalveolar lavage of mice. However, only the compound 5a1, derived from the esterification of gentisic acid, was able to significantly inhibit the levels of all pro-inflammatory cytokines and increase the levels of antiinflammatory cytokines evaluated.

Conclusion:

In conclusion, all compounds showed a good safety profile, and many of them had an antiinflammatory effect. However, the compound derived from gentisic acid is highlighted for its significant effects ex vivo and in vivo and in this context, we believe that this compound is a potential candidate for the development of a new anti-inflammatory drug.
Promising Role of Wolbachia as Anti-parasitic Drug Target and Eco-Friendly Biocontrol Agent
Authors: Chegeni Tooran Nayeri , Fakhar Mahdi
Published: February 2019

Background:

Wolbachia is the most common endosymbiotic bacteria in insectborne parasites and it is the most common reproductive parasite in the world. Wolbachia has been found worldwide in numerous arthropod and parasite species, including insects, terrestrial isopods, spiders, mites and filarial nematodes. There is a complicated relationship between Wolbachia and its hosts and in some cases, they create a mutual relationship instead of a parasitic relationship. Some species are not able to reproduce in the absence of infection with Wolbachia. Thus, the use of existing strains of Wolbachia bacteria offers a potential strategy for the control of the population of mosquitoes and other pests and diseases.

Methods:

We searched ten databases and reviewed published papers regarding the role of Wolbachia as a promising drug target and emerging biological control agents of parasitic diseases between 1996 and 2017 (22 years) were considered eligible. Also, in the current study several patents (WO008652), (US7723062), and (US 0345249 A1) were reviewed.

Results:

Endosymbiotic Wolbachia bacteria, which are inherited from mothers, is transmitted to mosquitoes and interferes with pathogen transmission. They can change the reproduction of their host. Wolbachia is transmitted through the cytoplasm of eggs and have evolved different mechanisms for manipulating the reproduction of its hosts, including the induction of reproductive incompatibility, parthenogenesis, and feminization. The extensive effects of Wolbachia on reproduction and host fitness have made Wolbachia the issue of growing attention as a potential biocontrol agent.

Conclusion:

Wolbachia has opened a new window to design a costly, potent and ecofriendly drug target for effective treatment and elimination of vector-borne parasitic diseases.
Two Novel Tri-Aryl Derivatives Attenuate the Invasion-Promoting Effects of Stromal Mesenchymal Stem Cells on Breast Cancer
Authors: Moradi Khadijeh , Barneh Farnaz , Irian Saeed , Amini Mohsen , Moradpoor Raheleh , Amanzadeh Amir , Choopani Samira , Rahimi Hamzeh , Ghodselahi Tayebeh , Boujar Massoud M. , Salimi Mona
Published: February 2019

Background:

The concept of Epithelial-Mesenchymal Transition (EMT) to promote carcinoma progression has been recognized as a venue for research on novel anticancer drugs. Triaryl template-based structures are one of the pivotal structural features found in a number of compounds with a wide variety of biological properties including anti-breast cancer. Among the various factors triggering EMT program, cyclooxygenase-2 (COX-2), NF-κB as well as the transforming growth factor-beta (TGF-β) have been widely investigated.

Objective:

Here, we aim to investigate the effect of two novel compounds A and B possessing triaryl structures, which interact with both COX-2 and TGF-β active sites and suppress NF-κB activation, on EMT in a co-culture system with breast cancer and stromal cells.

Methods:

MDA-MB-231 and bone-marrow mesenchymal stem (BM-MS) cells were co-cultured in a trans-well plate. Migration, matrigel-based invasion and colony formation in soft agar assays along with Real- time PCR and Western blot analysis were performed to examine the effect of compounds A and B on the invasive properties of MDA-MB-231 cells after 72 hours of co-culturing with BM-MSCs. In addition, TGF-beta interaction was investigated by Localized Surface Plasmon Resonance (LSPR).

Results:

BM-MSCs enhanced migration, invasion and anchorage-independent growth of the co-cultured MDAMB- 231 cells. A reduction in E-cadherin level concomitant with an increase in vimentin and N-cadherin levels following the co-culture implied EMT as the underlying process. Compounds A and B inhibited invasion and anchorage-independent growth of breast cancer cells co-cultured with BM-MSCs at 10µM. The observed inhibitory effects along with an increase in E-cadherin and a reduction in vimentin and ZEB2 levels suggest that the anti-invasive properties of compounds A and B might proceed through the blockade of stromal cell-induced EMT, mediated by their interaction with TGF-beta.

Conclusion:

These findings introduce compounds A and B as novel promising agents, which prevent EMT in invasive breast cancer cells.
Optimized Deep Neural Network Based Predictive Model for Customer Attrition Analysis in the Banking Sector
Authors: Hegde Sandeepkumar , Mundada Monica R.
Published: February 2019

Background:

In recent time with the growth of the technology and the business model, customer attrition analysis is considered as a very important metric which decides the revenues and profitability of the organization. It is applicable for all the business domains irrespective of the size of the business even including the start-ups. Because about 65% revenue for the organization comes from the existing customer. The goal of the customer attrition analysis is to predict the customer who is likely to exit or churn from the current business organization. In this research work, the literature review is carried out to explore the related work which has been already carried out in the field of customer attrition analysis. The literature review also focuses on some of the patents which are issued in the area of customer attrition or churn analysis. The goal of the research paper is to predict accurately the customer attrition rate in the Banking Sector.

Objective:

The main objective of this paper is to predict accurately the attrition rate in the Banking sector using an optimized deep feed-forward neural network.

Methods:

In the proposed work the predictive machine learning model is implemented using the optimized deep feed-forward neural network having five hidden layers in it. The model is trained using Adam optimizer algorithm to obtain the optimal accuracy. The Banking Churn data set is passed as input to the Optimized Deep Feed Forward Neural Network Model. In order to perform the comparative analysis, the same data set is passed as input to the other machine learning algorithm such as Decision Tree, Logistic Regression, Gaussian Naïve Bayes, and Artificial Neural Network.

Results:

The test results indicate that the proposed optimized deep feedforward neural Network model performed better in accuracy compared to existing machine learning techniques.

Conclusion:

The proposed optimized deep neural network model is an accurate model for customer attrition analysis in the Banking sector compared to the existing machine learning techniques.
Design & Real-time Implementation of MIDO Converter Based PV Water Pumping System with BES
Authors: Tomar Anuradha
Published: February 2019

Background:

Despite so many developments, most of the farmers in the rural areas are
still dependent on rainwater, rivers or water wells, for irrigation, drinking water etc. The main reason
behind such dependency is non-connectivity with the National grid and thus unavailability of
electricity. To extract the maximum power from solar photovoltaic (SPV) based system, implementation
of Maximum Power Point Tracking (MPPT) is mandatory. PV power is intermittent in nature.
Variation in the irradiation level due to partial shading or mismatching phenomena leads to the development
of modular DC-DC converters.

Methods:

A stand-alone Multi-Input Dual-Output (MIDO) DC-DC converter based SPV system, is
installed at a farm; surrounded with plants for water pumping with stable flow (not pulsating) along
with battery energy storage (BES) for lighting. The proposed work has two main objectives; first to
maximize the available PV power under shadowing and mismatching condition in case of series/
parallel connected PV modules and second is to improve the utilization of available PV energy
with dual loads connected to it. Implementation of proposed MIDO converter along with BES addresses
these objectives. First, MIDO controller ensures the MPPT operation of the SPV system to
extract maximum power even under partial shading condition and second, controls the power supplied
to the motor-pump system and BES. The proposed system is simulated in MATLAB/ SIMULINK
environment. Real-time experimental readings under natural sun irradiance through hardware
set-up are also taken under dynamic field conditions to validate the performance.

Results and Conclusion:

The inherent advantage of individual MPPT of each PV source in MIDO
configuration, under varying shadow patterns due to surrounding plants and trees is added to common
DC bus and therefore provides a better impact on PV power extraction as compared to conventional
PV based water pumping system. Multi-outputs at different supply voltages is another flag of
MIDO system. Both these aspects are implemented and working successfully at 92.75% efficiency.
Determination of Glutamate and GABA Released by Mouse Embryonic Stem Cells Using HILIC-ESI-MS/MS
Authors: Lv Haoyu , Tang Yabin , Sun Fan , An Shimin , Yang Xinjie , Li Wenbin , Wang Xiaosheng , Zhu Liang
Published: February 2019

Background:

In recent years, more and more researches have shown that neurotransmitters can also be synthesized and released by peripheral non-neural cells. However, specificity and high sensitivity detection means were required for confirming ESCs autocrine glutamate and γ - aminobutyric acid (GABA). Glutamate and GABA are water-soluble and polar compounds which cannot be retained on a reversed phase C18 column, and their contents are often at a trace level. On the other hand, the biological matrix such as cell culture fluid contains a large number of amino acids, vitamins, carbohydrates, inorganic ions and other substances. Therefore, the main problem is the selection of the chromatographic column to avoid matrix interference.

Objective:

To establish a rapid and reliable method for the simultaneous determination of glutamate and GABA released from embryonic stem cells based on analytical chemistry.

Methods:

Glutamate and GABA released from mouse embryonic stem cells were determined on the basis of hydrophilic interaction chromatography coupled with electrospray ionization tandem Mass Spectrometry (HILIC- ESI- MS/MS), using isotope internal standards and substitution matrix method.

Results:

Undifferentiated embryonic stem cells autocrine glutamate and GABA and will reach releasing- reuptacking dynamic equilibriums at different time points. In contrast, neither glutamate nor GABA releasing could be detected from the MEFs, indicating the specificity release of the mESCs in the applied analytic method.

Conclusion:

A novel, simple, sensitive, selective and quantitative method was developed for determination of the glutamate and GABA from mouse embryonic stem cells.
Nanocarriers(s) Based Approaches in Cancer Therapeutics
Authors: Yadav Vaishali , Jain Ashutosh Pal , Sharma Rajeev , Yadav Awesh K.
Published: February 2019

Nanomedicine is an emerging field, which constitutes a new direction in the treatment of cancer. The advent of nanotechnology has the potential to greatly facilitate the early detection and treatment of cancer. Nanocarriers are a group of nano-sized vehicles devised to deliver loaded bioactive(s) to target malignant cells, tissues or organs and have provided remarkably improved therapeutic efficacy for cancer therapy. A variety of nanocarriers(s)such as dendrimers, nanoparticle(s), liposomes, micelles, gold carriers, solid lipid carriers, carbon nanotubes, magnetic carriers and viral carriers, incorporating cytotoxic therapeutics have emerged as striking delivery system(s) in the area of cancer research. To improve the biological distribution of therapeutic bioactive(s), some modified carriers have designed to accommodate efficient loading and release of drugs with a wide spectrum of chemical and physical characteristics. In addition, physicochemical modifications of the surface or interior of NPs allow for modulation of pharmacokinetic features as per clinical demands. However, cancer-related mortality still remains high and drug-mediated cancer treatment is a challenging research field despite the remarkable advances in targeting efficiency and therapeutic efficacy demonstrated and resulted from NPs.This review focuses primarily on current nano drug delivery systems for cancer therapy. The current challenges related to therapeutic nanomedicines, as well as critical analysis of the different delivery nanoparticles, are also discussed.
Chitosan/Fluoride Nanoparticles for Preventing Dental Caries
Authors: Ebrahimi Niousha , Soleimani Ali Asghar , Rashidiani Jamal , Malekafzali Beheshteh , Abedini Fatemeh , Hosseinkhani Hossein
Published: February 2019

Background: Dental caries is still a major public health problem. The use of fluoride is
one of the most effective ways to prevent tooth decay.

Objective: The purpose of this research was to investigate the effectiveness of fluoride entrapped in
chitosan nanoparticles in vivo.

Methods: Sodium fluoride was loaded in chitosan via ionic gelation of tripolyphosphate nanoparticles.
Characterization of nanoparticles was investigated by using the zeta potential, size of particles,
loading capacities, encapsulation efficiency, and Fourier Transforms Infrared Spectroscopy. Chitosan/
fluoride nanoparticles were fabricated by a method of fluoride/chitosan cross-linking with
tripolyphosphate.

Results: The size of nanoparticles was 219 nm. According to the zeta potential results, by adding
sodium fluoride to chitosan/tripolyphosphate nanoparticles reducing the number of positive charges
of chitosan, the result was diminished zeta potential from +30.8 mV to +14.9 mV. The optimum
drug loading and percentage of entrapment efficiency were 70% and 30% respectively. Fourier
transform infrared spectroscopy confirmed linked among tripolyphosphate, chitosan and fluoride
nanoparticles. In vitro characterization of nanoparticles demonstrated higher fluoride uptake ability
and smooth releasing profile.

Conclusion: It is suggested that fluoride/chitosan nanoparticles synthesized in our study may be a
promising means of delivering fluoride for the early prevention of tooth decay.