bluuebunny/crossref_metadata_2025 huggingface dataset:
Association Splitting for Obsessive-Compulsive Disorder: A Systematic Review
Authors: Ching Terence H.W. , Jelinek Lena , Hauschildt Marit , Williams Monnica T.
Published: September 2019

Background:

Association splitting is a cognitive technique that targets obsessions in
obsessive-compulsive disorder (OCD) by weakening biased semantic associations among OCDrelevant
concepts.

Objective:

In this systematic review, we examine studies on the efficacy of association splitting for
reducing OCD symptoms.

Methods:

Following PRISMA guidelines, six studies were included, with diversity in sample characteristics,
mode of administration (i.e., self-help vs therapist-assisted), language of administration,
comparator groups, etc.

Results:

Results indicated that association splitting, as a self-help intervention, was efficacious in
reducing overall OCD symptom severity, specific OCD symptoms (i.e., sexual obsessions), subclinical
unwanted intrusions, and thought suppression, with small-to-large effect sizes (e.g., across
relevant studies, ds = .28-1.07). Findings were less clear when association splitting was administered
on a therapist-assisted basis as an add-on to standard cognitive-behavior therapy (CBT). Nonetheless,
across studies, the majority of participants reported high acceptability, ease of comprehension,
and adherence to daily association splitting practice.

Conclusion:

Although association splitting is an efficacious and acceptable self-help intervention
for OCD symptoms, future studies should include appropriate comparison groups, conduct longitudinal
assessments, examine efficacy for different symptom dimensions, and assess changes in semantic
networks as proof of mechanistic change. There should also be greater representation of
marginalized groups in future studies to assess association splitting’s utility in circumventing barriers
to face-to-face CBT. Ethical considerations are also discussed.
Experimental Analysis of Performance and Thermal Capability of Three Phase Squirrel Cage Induction Motor Using Plastered Composite Conductors
Authors: Balamurugan N. , Selvaperumal S.
Published: September 2019

Background:

This article deals with the analysis on improved performance and efficiency
of induction motor by using nano composites for stator winding.

Methods:

The nanocomposites are added with different enamel. Enamel is mostly preferred for induction
motors’ winding, due to three main reasons: adhesion, infusion and plaster. To predetermine the
plaster and nanocomposite conductor’s behavior when they are used for transmitting AC currents and
developing AC magnetic field, a numerical analysis is performed. The total heat losses are determined
by the heat run test. Open circuit and short circuit tests are used to analyze the performance and efficiency
of the proposed induction motor.

Results:

The AC losses of composite and plaster conductors having good accord are compared with
previous solid and hollow conductors. Analysis of the coil by a composite and plaster conductor
shows that the AC losses in low current are lower than the coil, which is wrapped by a solid, and hallow
conductors. Due to this reason, composite and plaster conductors are considered advantageous for
low and medium power motors.

Conclusion:

Adding nano composites with the plaster material will help to improve electrical, thermal
and mechanical characteristics. The property of enamel can change the lifetime of induction motor.
The induction motor winding makes use of nano composites SiO2 and TiO2 with enamel coated.
Performance Evaluation of Neural Network for Human Classification Using Blob Dataset
Authors: Mehta Monika , Bhadauria Madhulika
Published: September 2019

Background:

Human Classification in public places is an emerging area in the applications
of Computational Intelligence. Therefore, modeling of an optimal architecture of the neural
network is required to classify them.

Methods:

In this work for this purpose, blob dataset has been used to train the neural network. This
dataset consists of 2408 features of a human blob.

Results:

Further, analysis of this blob dataset has been done on the basis of various characteristic parameters
for affirmation of actual training. During training and testing of this dataset, it has been observed
that when nodes at hidden layer are below and above 10 then training of neural network is
under fitted and overfitted respectively and works effectively when the nodes are 10 at the hidden
layer.

Conclusion:

From the experimental work performed in this study, an optimal neural network has
been obtained to classify human using blob dataset.
TEK KULLANIMLIK SPUNBOND KUMAŞLARDA HİDROFİLİK VERİMLİLİĞİ ÜZERİNE BİR ÇALIŞMA
Authors: Dönmez Utkay , Kaçmaz Emrah , Kurt Hacı Arif
Published: September 2019

Dokusuz
yüzey sektöründe spunbond kumaşlar, en çok kullanım olanağı olan kumaşlardır.
Bunlardan bazıları çocuk bezi üretiminde kullanılmaktadır. Ancak kumaşların
kullanım yerine göre sıvı geçirgenliği ve geri ıslatma miktarı özellikleri önem
arz etmektedir. Bu sebepten spunbond kumaş üreticileri hidrofilik kimyasallar
kullanmaktadır. Bu çalışmada, 4 farklı kimyasal, 2 farklı çözelti oranı ve 3
farklı besleme hızı ile spunbond kumaşa aplike edilmiş ve kumaşların
performansları incelenmiştir. Sıvı emiş süresi, geri ıslatma miktarı ve
tüketilen kimyasal miktarı göz önüne alınarak bir işletme için en uygun
kimyasal ve çözelti oranları seçilmiştir.
TÜRKİYE’DE HİDROLOJİK VERİ YÖNETİMİ VE ÜNİVERSİTELERİN KATILIMI ABD ÖRNEĞİ
Authors: AKSU Hakan , KORKMAZ Mehmet Seren
Published: September 2019

Su
kaynaklarının etkin kullanımında, projelerin yapılabilirliğine esas teşkil eden
hidrolojik verinin önemi çok büyüktür. Hidrolojik veri, saha gözlemleri,
ölçümler ve sonrasındaki çözümlemeler ile kullanıcılara sunulmaktadır Bununla
beraber, toplanan ve sunulan hidrolojik verinin kullanım amacı, başta su
mühendisliği projeleri olsa da, ayrıca bilimsel amaçlı araştırmalar da su
kaynaklarının etkin kullanımı için aynı derecede önemlidir. Hidrolojik verinin
üretilip sunulmasında, kamu kuruluşlarının hizmet kalitesi yıllar içerisinde
oldukça gelişmiştir. Ülkemizde su kaynakları ile ilgili çalışan akademisyen ve
araştırmacıların sayısı her geçen gün artmaktadır. Ülkemizde ilerleyen zamanda
CUAHSI benzeri çatı oluşumlar ile kamu kuruluşları tarafından üretilen ve
hizmete sunulan Hidrolojik verilerin kullanıldığı bilimsel çalışmaların hem
sayısının hem de kalitesinin artacağı dile getirilmektedir.
A COMPARISON OF QUARTZ SANDS WITH DIFFERENT MINERALOGY AND THEIR GRIDING DERIVATIONS
Authors: ÇELLEK Seda
Published: September 2019

Griding sand is
specifically used to treat clays that tend to swell. Each of the sands has its
unique physical properties. For that reason, it is necessary to determine the
engineering properties of the sand used. In this study, four types of sand with
different mineralogy were examined. After determining the engineering
properties of these sands, three different specimens per sample, with different
size distributions, were obtained by grinding them up to the size of clay and
silt. As a result, it was determined that the twelve sand samples consisted of
poorly sorted sand and the physical properties of the sands with different
mineralogy were different to each other. The largest difference in derivatives
was found in Type 1 sand of magmatic origin. It was observed that the original
sand used in all experimental results gave higher values than the finer grained
derivative samples. As a result, the engineering properties of the sands
changed with the reduction in grain sizes. In addition, it was determined that
the derivatives obtained by grinding the sand with different mineralogy exhibit
different behaviors.
A Smartphone App to Improve Medication Adherence in Patients With Type 2 Diabetes in Asia: Feasibility Randomized Controlled Trial
Authors: Huang Zhilian , Tan Eberta , Lum Elaine , Sloot Peter , Boehm Bernhard Otto , Car Josip
Published: September 2019

Background

The efficacy of smartphone apps for improving medication adherence in type 2 diabetes is not well studied in Asian populations.

Objective

This study aimed to determine the feasibility, acceptability, and clinical outcomes of using a smartphone app to improve medication adherence in a multiethnic Asian population with type 2 diabetes.

Methods

We block randomized 51 nonadherent and digitally literate patients with type 2 diabetes between the ages of 21 and 75 years into two treatment arms (control: usual care; intervention: usual care+Medisafe app) and followed them up for 12 weeks. Recruitment occurred at a public tertiary diabetes specialist outpatient center in Singapore. The intervention group received email reminders to complete online surveys monthly, while the control group only received an email reminder(s) at the end of the study. Barriers to medication adherence and self-appraisal of diabetes were assessed using the Adherence Starts with Knowledge-12 (ASK-12) and Appraisal of Diabetes Scale (ADS) questionnaires at baseline and poststudy in both groups. Perception toward medication adherence and app usage, attitude, and satisfaction were assessed in the intervention group during and after the follow-up period. Sociodemographic data were collected at baseline. Clinical data (ie, hemoglobin A1c, body mass index, low-density lipoprotein, high-density lipoprotein, and total cholesterol levels) were extracted from patients’ electronic medical records.

Results

A total of 51 (intervention group: 25 [49%]; control group: 26 [51%]) participants were randomized, of which 41 (intervention group: 22 [88.0%]; control group: 19 [73.1%]) completed the poststudy survey. The baseline-adjusted poststudy ASK-12 score was significantly lower in the intervention group than in the control group (mean difference: 4.7, P=.01). No changes were observed in the clinical outcomes. The average 12-week medication adherence rate of participants tracked by the app was between 38.3% and 100% in the intervention group. The majority (>80%) of the participants agreed that the app was easy to use and made them more adherent to their medication.

Conclusions

Our feasibility study showed that among medication-nonadherent patients with type 2 diabetes, a smartphone app intervention was acceptable, improved awareness of medication adherence, and reduced self-reported barriers to medication adherence, but did not improve clinical outcomes in a developed Asian setting.
ANALYSIS OF FERULIC ACID IN ARABICA COFFEE BEAN (COFFEA ARABICA L.) USING SOLID PHASE EXTRACTION–HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
Authors: MUSFIROH IDA , INDRIYATI WIWIEK , NUR ABADI MIRA LAILA , MUCHTARIDI MUCHTARIDI
Published: September 2019

Objective: The purpose of this research is quantitatively analyzing of ferulic acid in the Arabica coffee bean extract from three samples with different regions (Garut, Pangalengan, Tasikmalaya, West Java Indonesia) using Solid Phase Extraction-High Performance Liquid Chromatography (SPE-HPLC) method which is validated.

Methods: The analysis method used reversed phase HPLC with an Enduro C 18 G (250 mm × 4.6 mm) column and detector UV 312 nm, with a mobile phase of methanol and water containing 1% (v/v) of acetic acid (42:58) at a flow rate of 1.0 ml/min and validation method was examined in linearity, Limit of Detection (LOD), Limit of Quantification (LOQ), precision, and accuracy.

Results: The results showed that the precision of retention was 8.853 min, correlation coefficient (R) was 0.9996, and the recovery was 96.909%. The quantitative analysis of ferulic acid content in the extract of coffee from thus samples of three different regions were 0.0385%, 0.0169% and 0.0076%, respectively.

Conclusion: The analytical method was meet the validation criteria. Ferulic acid levels results from the extraction of the digestion process and pretreatment methods of Solid Phase Extraction (SPE) is 0.0385% from Garut area, 0.0169% from Pangalengan area and 0.0076% from Tasikmalaya area.
FORMULATION AND EVALUATION OF AMOXICILLIN-TRIHYDRATE, METRONIDAZOLE AND FAMOTIDINE LOADED-MUCOADHESIVE GASTRO-RETENTIVE FILMS
Authors: NIDHI JAIN SINGHAI  , MAURYA RAHUL , RAMTEKE SUMAN , JAIN SANJAY K.
Published: September 2019

Objective: To developed mucoadhesive gastro-retentive films of amoxicillin trihydrate, metronidazole and famotidine by using polymers and plasticizer for eradication of H. pylori infection.

Methods: The mucoadhesive gastro-retentive films of amoxicillin trihydrate, metronidazole and famotidine were prepared using solvent casting method. The optimized gastro-retentive films were characterized by using various parameters such as DSC, drug content uniformity, in vitro drug release, FTIR spectroscopy, SEM and ex-vivo drug permeation studies across the mucous membrane. The prepared mucoadhesive gastro-retentive films were evaluated with in vitro growth inhibition study and in vivo bacterial clearance study.

Results: The FTIR spectra indicated that there was no any interaction between the drugs and polymer. Drugs content was found to be in the range and there was no significant change in the surface morphology of the films after under storage. The bioadhesive property of prepared films exhibited highly bioadhesive property when increased the amount of chitosan and PAA (Polyacrylic Acid) used. We found that CH-PAA IPC (Chitosan-Polyacrylic Acid Inter-polymer Complex) films exhibited greater bioadhesion. The percent of growth inhibition by using each drug such as amoxicillin, metronidazole and famotidine was found to be 51.61%, 46.59% and 34.76%, respectively whereas the combination of drugs were exhibited highest % growth inhibition. The % inhibition was found to be 81.00%. The optimized formulation CH-PAA IPC (C1P2G2) and CH film (C1G2) showed highest growth inhibition of H. pylori bacteria. The growth inhibition was found to be 96.77% and 92.26%, respectively. In vivo Bacterial Clearance Studies showed that the drugs loaded CH-PAA IPC film (C1P2G2) formulation exhibited better clearance from infection than CH film (C1G2) formulation and plain drugs solution at same doses. Drugs loaded CH-PAA IPC film formulation was found to be effective in the treatment of H. pylori infections effectively.

Conclusion: The developed gastro-retentive films of amoxicillin trihydrate, metronidazole and famotidine combination could be used for batter management of mucosal ulcer disease and eradication of H. pylori bacteria.
DEVELOPMENT OF TAMOXIFEN CITRATE PELLETS BY HOT-MELT EXTRUSION FOR IMMEDIATE RELEASE: STUDY OF EFFECT OF VARIABLES
Authors: YADAV VISHAL , KUMAR S. SATHESH
Published: September 2019

Objective: Objective of the study was to develop tamoxifen citrate immediate release pellets by hot-melt extrusion (HME) and to study the effect of various formulation and process variables.

Methods: Pellets were prepared by HME technique. Effect of various parameters such as the concentration of ethylcellulose, PEG 6000, croscarmellose sodium, and spheronization speed were studied by using Central Composite Design. Pellets were evaluated for theoretical yield (%), mean pellet size (mm), sphericity (pellips), friability (%), porosity (%), mechanical crushing force (n), and dissolution efficiency. Optimized formulation was studied for compatibility study using IR, DSC, and XRD, SEM, In vitro drug release. In vitro Cell Cytotoxicity and Viability Assay were carried out using MCF-7 (human breast cancer cells) by MTT assay.

Results: Results showed that a variable such as the amount of Methyl Cellulose, PEG 6000 and Spheronization speed showed positive correlation and amount of Croscarmellose sodium showed a negative correlation with dependent variables. Optimized formulation showed Korsmeyer Peppas model as a mechanism of drug release. Value of n was found to be in between 0.77+0.04, which reveals that, release mechanism of the drug as non-Fickian transport (0.45<n<0.89). MTT results of MCF-7 cells showed that optimized immediate release pellets have maximum cytotoxicity at 80 µg/ml.

Conclusion: Study concluded that HME method and materials i.e. PEG 6000 and methylcellulose can effectively use to get immediate release of tamoxifen citrate so as to increase dissolution rate and cytotoxic effect.
FORMULATION AND IN VITRO CHARACTERISATION OF SOYBEAN OIL-HPMCK4M BASED BIGEL MATRIX FOR TOPICAL DRUG DELIVERY
Authors: MUKHERJEE SHUBHAM , MAJEE SUTAPA BISWAS , BISWAS GOPA ROY
Published: September 2019

Objective: Hydrogels with scope for utilization in numerous fields possess limited applications due to problems in incorporating wide range of drugs and crossing the lipophilic barrier of the skin. Attempts to overcome these problems by developing organogel hold drawbacks. Challenges posed by drug lipophilicity or skin permeation can be solved by developing bigel formed via combination of lipophilic and hydrophilic gel phases in a definite proportion. The objective of the present study is to formulate and characterize matrix type bigel of soybean oil and HPMCK4M for topical drug delivery.

Methods: Four batches of bigels were developed with two organogel formulations of soybean oil containing 20 and 22% w/v Span 60. Both organogels and bigels were examined for compatibility by FTIR spectroscopy, hemocompatibility and characterized for physical appearance, pH, rheological behavior and in vitro drug release pattern.

Results: FTIR study confirmed compatibility between paracetamol and components of organogel or bigel. The oily feel of organogels disappeared with bigels which possessed a creamy and smooth texture. Pseudoplastic behaviour was confirmed by Ostwald-de wale power-law model in both organogels and bigels. Improved drug release was observed in bigel (BG1) formulation containing 3%w/v HPMCK4M and soybean oil based organogel with 20% w/v Span 60 as compared to the corresponding organogel (OG1). Organogels were foundto follow either zero-order kinetics (OG1) or Korsmeyer-Peppasmodel (OG2) while the formation of matrix was exhibited in bigels with drug diffusion predominantly of non-Fickian type.

Conclusion: Therefore, bigels of soybean oil based organogel with HPMCK4M hydrogel formed gel matrix demonstrating improved drug release for topical application compared to organogel.
FORMULATION AND IMMUNOSTIMULANT STABILITY POLYSACCHARIDE SYRUP OF FRACTION NONI (MORINDA CITRIFOLIA L.) FRUITS
Authors: E. Ediati , Saifullah T.N. , R. Rumiyati , MM. DUNSTANIA , P. MARIA QUEEN , S. ERNA MARIANA
Published: September 2019

Objective: The study aimed to formulate standardized polysaccharide fraction of Noni (SPFN) fruit into syrup preparations to fulfill the acceptability requirement of National Agency of Drugs and Food Control [Badan Pengawas Obat dan Makanan Republik of Indonesia (BPOM RI)] so that it can be used in the community as an immunostimulant.

Methods: The optimization of the formula A and B were done using Simplex Lattice Design (SLD) method and its stability tested under extreme temperature change effect using thaw cycling method by evaluating the physical properties, microbial contamination and immunostimulant activity. MTT method was used to determine the immunostimulant activity of syrup against lymphocyte proliferation in vitro.

Results: Based on the results of stability tests of formula A using pH (4.45), viscosity (81.03 mPas), taste (good taste), pouring power (2.31 s), amount of bacteria (68 colonies/ml), total yeast and mold (269 colonies/ml) parameters and fulfilled the acceptability requirement of BPOM RI. Formula A could maintain better stability than formula B. Formula A syrup used for immunostimulant activity testing that could increase lymphocyte proliferation at a concentration of 13.33 to 106.64 μg/μl and it’s stable under the influence of extreme temperature changes.

Conclusion: Formula A could be used to produce SPFN syrup, which has stable physical properties and immunostimulant activity beside no microbial contamination that fulfill requirements of BPOM RI.
DERMAL DELIVERY OF DOCETAXEL LOADED NANO LIQUID CRYSTALS FOR THE TREATMENT OF SKIN CANCER
Authors: MAJUMDAR ARTI , DUBEY NIDHI , DUBEY NITIN
Published: September 2019

Objective: The aim of the present study is to develop docetaxel-loaded nano liquid crystals (NLCs) to enhanced and effective delivery of the drug to the skin cancer.

Methods: NLCs bearing docetaxel were prepared by an emulsification solvent diffusion method. The formulated NLCs were characterized for average particle size, polydispersity index (PDI) Zeta potential, entrapment efficiency and in vitro drug release study. The prepared formulations were studied for it's in vitro cell line and cell uptake study.

Results: It was revealed that the average size of NLCs was found 178.3±5.07, PDI was 0.189, percent entrapment efficiency was found 71.3±2.49 and Zeta potential was found-17.3±2.4. In vitro release determined by Franz diffusion cell was found 61.6±3.2% after 72 hr. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay shows that Docetaxel loaded NLCs were giving more cytotoxicity as compared to the plain drug. The cell uptake study was found enhanced uptake of fluorescein isothiocyanate (FITC) loaded NLCs in comparison to plain FITC. Docetaxel and docetaxel-loaded NLCs showed 28.3±0.3 and 39.3±1.3 growth inhibition respectively after 48h upon incubation at 0.5 µg/ml concentration (p<0.05).

Conclusion: The result of the studies was concluded that NLCs can be used as impending drug delivery system which may enhance the drug uptake and maintain the drug level for longer period of time and it is potential carrier system which can be used for the treatment of skin diseases like cancer.
LIGHT SCATTERING IN RESEARCH AND QUALITY CONTROL OF DEUTERIUM DEPLETED WATER FOR PHARMACEUTICAL APPLICATION
Authors: KOLDINA A. M. , USPENSKAYA E. V. , BORODIN A. A. , PLETENEVA T. V. , SYROESHKIN A. V.
Published: September 2019

Objective: Development of a methodology for measuring the deuterium content in water for pharmaceutical purposes by laser light scattering based on ideas about the cluster structure of water.

Methods: Samples of industrially manufactured drinking water from different manufacturers with varying deuterium content from 10 ppm to 115 ppm. For the titration of laboratory samples of deuterium depleted water in increments of 5 ppm the following reagents were used: Water, deuterium-depleted (≤1 ppm (D2O, Aldrich, USA); Deuterium oxide/Heavy water/Water-d2 (99.9 atom % D, Aldrich, USA); water Milli-Q (specific resistance 18.2 µS·sm at 25 оС, ТОС ≤ 5 ppb, Merck Millipore). The determination of deuterium content in samples of industrially manufactured water and water obtained in a laboratory manner was carried out by the method of low-angle laser light scattering (LALLS) at the Mastersizer (Malvern Instruments) analyzer and using a working measuring tool–laser dispersion meter/MDL («Cluster-1», Russia/Ukraine). The statistical methods–packages OriginPro®9.

Results: It was found that the content of isotopologies in water leads to physicochemical water’s properties changes and morphology changes of giant heterogeneous clusters (GHC). The results of low-angle laser light scattering (LALLS) in the water samples under investigation showed the dependence of the water GHC "dispersibility" expressed in the differentiation of curves of the volume size distribution ("size spectra"), the volume concentration, w%, the laser obscuration values (I ‒I0) as the function of the water isotopic composition variations. The laser diffraction method results correlate with two-dimensional (2D) multi-descriptor mathematical analysis.

Conclusion: When identifying deuterium depleted water, it should be considered not only the indicators that determine its pharmacopoeial quality, but also the D/H ratio, because even small changes in the natural isotopic composition of water lead to significant biological effects. Our proposed approach using laser diffraction in combination with mathematical apparatus of (2D) multi-descriptor laser scattering analysis makes possible the exact calculation of individual signs of deuterium depleted water as the pharmaceutical object of study.
FORMULATION AND EVALUATION OF FEBUXOSTAT FAST DISSOLVING TABLETS USING ENTADA SCANDENS SEED STARCH AND POLOXAMER-188 AS SUPERDISINTEGRANTS
Authors: DOPPALAPUDI SANDEEP , SURYADEVARA VIDYADHARA , JUJALA CHIRUDEEP
Published: September 2019

Objective: The present study focused on solubility enhancement of the Biopharmaceutical Classification System (BCS) Class-II drug, Febuxostat using various super disintegrants.

Methods: Starches were extracted from Entada scandens seed powder by alkali method i.e., sodium hydroxide at 0.1%, 0.25% and 0.5% concentrations and water. Starches were evaluated for various phytochemical and physicochemical tests. Solid dispersions of Febuxostat were prepared by fusion method using poloxamer-188 alone and by mixing poloxamer-188 with Entada scandens seed starch. Various physical parameters were evaluated for these solid dispersions. Tablets were prepared using Febuxostat solid dispersions and varying concentrations of Entada scandens seed starch by direct compression technique. Pre and post-compression parameters were evaluated along with in vitro drug release studies, characterization studies like Fourier Transform Infra-Red spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD) and stability studies.

Results: Phytochemical tests revealed the presence of starch in all extracts. Starch prepared from 0.5% sodium hydroxide (ESS4) showed best physicochemical properties. In vitro dissolution studies revealed that solid dispersion F4 containing Febuxostat and poloxamer-188 in 1:3 ratios showed better drug release. Formulation FE5 containing F4 solid dispersion with 12.5% w/w of ESS4 showed enhanced drug release. FT2 tablets having 12.5% w/w of ESS4 showed better drug release when compared to others. FTIR and DSC studies revealed no major interactions between drug and excipients. XRD studies revealed the nature of formulations. Accelerated stability studies showed that all tablets were stable.

Conclusion: The super disintegrant property of Entada scandens seed starch was evaluated.
FORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE GASTRORETENTIVE TABLET OF EMTRICITABINE
Authors: RADHA G. V. , SASTRI K. TRIDEVA , MANASWIN N. , LIKHITHA B.
Published: September 2019

Objective: The study aims for the design and evaluation of floating tablets of emtricitabine (EMT), post oral administration to sustain the release and enhance gastric residence time (GRT).

Methods: EMT is a nucleoside reverse-transcriptase inhibitor for the prevention and treatment of human immunodeficiency virus (HIV) infection. The investigation was considered to formulate a floating tablet of EMT with various agents. The formulation included with various concentrations of hydroxypropyl methylcellulose (HPMC) k4m, ethylcellulose, microcrystalline cellulose, polyvinylpyrrolidone (PVP) by wet granulation method. Various parameters for the prepared formulations were evaluated for weight variation, thickness, hardness, friability, floating lag time (FLT), total floating time (TFT), swelling index, in vitro drug release, and fourier-transform infrared spectroscopy (FTIR) studies.

Results: The best formulation F1 exhibited 88.28% release in 24 h duration, with a floating lag time of 7 min and swelling index of 52.1% and drug content was determined to be 98.27%. The release mechanism was determined to be first order with higuchi release kinetics displaying diffusion along with the dissolution of the EMT from the tablet by non fickian mechanism.

Conclusion: EMT tablets showed an increased GRT with a sustained release for 24 h thereby allowing a better window for absorption consequently improve the therapeutic effect of the drug.
COMENTARIO A LA PONENCIA DE SERGIO BAGÚ.
Authors: Leal Juan Felipe
Published: September 2019

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ESTANCAMIENTO Y DESARROLLO ECONÓMICO EN EL SIGLO XIX MEXICANO.
Authors: Canudas S. Enrique
Published: September 2019

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COMENTARIO A LA PONENCIA DE ENRIQUE CANUDAS.
Authors: Florescano Enrique
Published: September 2019

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LAS ETAPAS DEL DESARROLLO AGROPECUARIO EN EL SIGLO XX.
Authors: Warman Arturo
Published: September 2019

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PRODUCCIÓN Y CLASE OBRERA EN EL SIGLO XIX.
Authors: De Gortari Hira , Sandoval Roberto
Published: September 2019

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NOTAS SOBRE LA PERIODIZACIÓN DEL MOVIMIENTO OBRERO.
Authors: Baena Guillermina , Rivera C. José , Trejo D. Raúl , Woldenberg K. José
Published: September 2019

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LA PERIODIZACIÓN DE LA HISTORIA POLÍTICA DE MÉXICO EN EL SIGLO XX.
Authors: Meyer Lorenzo
Published: September 2019

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HOMENAJE AL DOCTOR FRANCISCO LÓPEZ CÁMARA
Authors: Márquez Fuentes Manuel
Published: September 2019

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LA CONSTRUCCIÓN DE LA IMAGEN DE UN CANDIDATO, EL CASÓ DE LOS CANDIDATOS PRIÍSTAS
Authors: Baena Paz Guillermina
Published: September 2019

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LA RUTA DEL SEGUNDO LUGAR: LA CAMPAÑA PRESIDENCIAL DEL PAN EN 1994
Authors: Reveles Vázquez Francisco
Published: September 2019

En este artículo se analiza el hecho de que, con un candidato sumamente criticado dentro y fuera del partido. Acción Nacional pudo sortear el enrarecido ambiente político que se mantuvo a lo largo del proceso electoral. Sin aprovechar cabalmente la consolidación de la organización, el PAN ganó simpatizantes principalmente mediante los medios de comunicación. Confirmó el  abandono de la anterior postura de enfrentamiento con el gobierno y reiteró su línea en cuanto al resto de la oposición. Y si bien los resultados dieron de nuevo a este partido el segundo lugar, no se ha logrado desvanecer la idea de la relación armónica con el gobierno como elemento esencial en la estrategia política del partido.
LOS CONSEJEROS CIUDADANOS Y LAS ELECCIONES FEDERALES DE 1994, ENTREVISTA CON JOSÉ WOLDENBERG
Authors: Valverde Viesca Karla
Published: September 2019

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EL PARTIDO DEL TRABAJO ¿LA NUEVA IZQUIERDA?
Authors: Villanueva Eretza Felipe
Published: September 2019

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SEIS HIPÓTESIS SOBRE LAS ELECCIONES PRESIDENCIALES DE 1994 Y ALGUNAS PREDICCIONES
Authors: Zavala Iván
Published: September 2019

Este trabajo, recurriendo a datos agregados demográficos y electorales de 260 distritos federales, analiza seis hipótesis sobre la elección presidencial mexicana de 1994. Esos hipótesis se resumen en que los grupos sociales "tradicionales" votan por el PRI y por el PRD, mientras que los "modernos" votan por el PAN. Concluye que esta elección representa una cierta reestructuración global de las bases sociales de los partidos, en la que el PRI es el partido más afectado.
LA DEMOCRACIA EN LA FILOSOFÍA POLÍTICA
Authors: Suárez-Íñiguez Enrique
Published: September 2019

La democracia es un tema en boga hoy en día. Todo mundo, cualesquiera que sean sus verdaderas predilecciones potíticas, se dice demócrata o habla de democracia. A nadie conviene parecer contrario a ella. Pero ¿qué es la democracia?, ¿Como la concibieron los clásicos y cómo se plantea hoy?, ¿cómo la caracteriza la filosofía política? El presente artículo en su primera parte revisa lo que sobre democracia sostuvieron los filósofos políticos clásicos: Platón, Aristóteles, Cicerón, Santo Tomás, Bodin, Hobbes, Locke, Moniesquieu, Rousseau y Tocqueville. En la segunda, el autor analiza lo que los filósofos políticos contemporáneos han aportado a la comprensión de la democracia: Popper, Rawls, Nozick, Macpherson, Sartori y Bobbio. El trabajo diferencia a la democracia como fue entendida originalmente, una forma de gobierno, y como se entiende hoy: el modelo político de la civilización occidental.
EVALUACIÓN CURRICULAR DE LA LICENCIATURA EN CIENCIAS POLÍTICAS Y ADMINISTRACIÓN PÚBLICA (CIENCIA POLÍTICA)
Authors: Carrera en Ciencias Politicas Comisión local de la
Published: September 2019

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ENCUESTA DE EGRESADOS DE LA LICENCIATURA DE CIENCIA POLÍTICA
Authors: Romero Moreno Lilián R. , Vargas Menchaca Olga Estela
Published: September 2019

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¿QUE POLITOLOGOS QUEREMOS? UNA REFLEXIÓN A PROPÓSITO DEL PLAN DE ESTUDIOS DE CIENCIA POLÍTICA
Authors: Hernández Arteaga Laura
Published: September 2019

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NUEVOS HORIZONTES
Authors: Béjar A. Luisa
Published: September 2019

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Sobre Antonio Argüelles y José A. Gómez, Guía metodológica para la desconcentración y modernización de estructuras administrativas.
Authors: Vargas Saúl
Published: September 2019

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GLOBALIZACIÓN Y ESTADO-NACIÓN: LAS POLÍTICAS SOCIALES DE LA NUEVA ERA
Authors: Novoa Edgar A , Restrepo Darío I
Published: September 2019

La crisis del Estado patrímonialista de bienestar y la emergencia del Estado neoliberal explican los cambios institucionales y programáticos de las nuevas políticas sociales. Mediante ellas asistimos a la creación de un nuevo sujeto social: del trabajador asalariado al trabajador social; del trabajo sometido a la empresa y al Estado, al trabajo subsumido en la esfera de lo público y del mercado.
OLIGARQUÍA, IDEOLOGÍA Y RACISMO EN EL CENTRO DE CHIAPAS: ELEMENTOS PARA UNA DISCUSIÓN TEÓRICO-METODOLÓGICA
Authors: Gall Olivia
Published: September 2019

El artículo que aquí presento está constituido por una serie de flexiones tanto históricas como teórico-metodológicas en torno a la historia de la discriminación racial y socio-cultural contra los indígenas en el estado de Chiapas a lo largo del último siglo. Estas reflexiones han surgido a raíz de la elaboración de un proyecto de investigación sobre el tema, que intenta relacionar la historia política con la historia cultural y estudiar esta discriminación desde el punto de vista tanto de la producción de ideología como de la construcción de identidades y alteridades socioculturales.
EVALUACIÓN DE LA CARRERA DE CIENCIA POLÍTICA EN MÉXICO: ENTREVISTAS CON ESPECIALISTAS
Authors: Zamitiz G. Héctor
Published: September 2019

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HEGEMONIA Y DISIDENCIA POLÍTICO-RELIGIOSA EN CHAMULA
Authors: Hernández A. Juan Luis , Prado Galán Javier
Published: September 2019

El artículo presenta un análisis de las implicaciones políticas, retíposas, sociales, culturales y económicos del fenomeno de las expulsiones de evangélicos en Chamula. Chiapas. o través del estudio de dos ejes conductuales; hegemonía y disidencia. El enfrentamiento entre una oligarquía rural con pretensiones de hegemonía político-religiosa y una disidencia político-religiosa que busca
crearse un espacio de independencia, muestra la realidad ineludible de la intersección entre los valores políticos y religiosos en una sociedad que no está preparada para asimilarlo.
FEMINISMO Y POLÍTICA. ¿CÓMO SE CONSTRUYE LA CREDIBILIDAD?
Authors: Cuéllar Vázquez Angélica
Published: September 2019

El artículo hace algunos cuestionamientos y sugiere algunos hipótesis sobre la forma en que algunos movimientos sociales con características de lo que Claus Offe ha denominado el "nuevo paradigma" conciben la política y se vinculan a los partidos políticos. El movimiento feminista en México, analizado en el artículo. guarda algunas características señalados por Offe. En esa línea se analiza el comportamiento político del feminismo en coyunturas electorales y se problematiza su actuar político en los últimos años.
LOS PERFILES DE UNA EDUCACIÓN PARA EL SIGLO XXI
Authors: De la Garza Luis Alberto
Published: September 2019

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EL PERFIL DEL PROFESIONAL DE LA CIENCIA POLÍTICA: ELEMENTOS PARA SU DISEÑO
Authors: Trejo Romo Pablo
Published: September 2019

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POLÍTICA Y RELIGIÓN
Authors: Hernández Avendaño Juan Luis
Published: September 2019

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Para una nueva mecánica del federalismo.
Authors: ARIAS MARÍN Alán
Published: September 2019

Los complejos cambios políticos e institucionales por los que atraviesa México, han creado la necesidad de modificar sustancialmente al sistema de representación y la estructura del poder nacional. El federalismo ocupa un espacio fundamental en la nueva agenda del país, por los que este artículo analiza el centralismo y la heterogeneidad regional en México; el federalismo mexicano en el marco de las relaciones intergubernamentales; el modelo teórico de las relaciones para México, y propuestas para la coordinación de los tres órdenes de gobierno en un nuevo federalismo en México.
Legitimación posmoderna (J.F. Lyotard: la condición posmoderna).
Authors: AYALA BLANCO Luis Alberto
Published: September 2019

En este ensayo se retoma el texto de J.F. Lyotard, la condición posmoderna. Lyotard centra la diferencia entre modernidad y posmodernidad básicamente en el proceso de legitimación. Señala el paso de una sociedad que se legitimó con base en los grandes metarrelatos, a otra donde el metarrelato ha muerto y por tanto los procesos de legitimación han adoptado características que no se pueden analizar con los mismo parámetros de la modernidad.
La era del desarrollo, o la recolonización del sur.
Authors: MÁRQUEZ MUÑOZ Jorge Federico
Published: September 2019

En este ensayo se expone el concepto de desarrollo y sus implicaciones para describir campos y realidades; desarrollo económico, biológico, lingüístico, etcétera.
Insuficiencia pancreática exocrina por atrofia pancreática en un perro: informe de caso
Authors: Rojas-Silva Alejandro David , Silva-Campos Francis Lee , Olivares-Salazar Mariana Isabel , Ramírez-Díaz María De Guadalupe , Morales-Salinas Elizabeth
Published: September 2019

Clínica Veterinaria: abordaje diagnóstico y terapéutico ISSN: 2395-8766Una forma de citar este artículo:Rojas-Silva AD, Silva-Campos FL, Olivares-Salazar MI, Ramírez-Díaz M de G, Morales-Salinas E. Insuficiencia pancreática exocrina por atrofia pancreática en un perro: informe de caso. Clínica Veterinaria: abordaje diagnóstico y terapéutico. 2019;5:e-33201956. doi:10.22201/fmvz.23958766e.201941Descripción del caso. Se presentó al Hospital Veterinario de Especialidades UNAM (HVE-UNAM) un perro, macho entero, de un año seis meses, bulldog francés, el motivo de consulta fue pérdida progresiva de peso, diarrea con cuatro meses de evolución, y uno a dos vómitos por día.Hallazgos clínicos. Condición corporal (CC) 1/5, en la palpación transabdominal, asas intestinales engrosadas, derrame abdominal y posible cuerpo extraño observado mediante ultrasonido abdominal.Tratamiento y evolución. Se le administró ranitidina, metronidazol, solución Hartmann, fenbendazol, omeprazol, citrato de maropitant, prednisona, nalbufina y alimento gastrointestinal bajo en grasa, sin respuesta favorable.Pruebas de laboratorio. Se realizaron hemogramas, bioquímicas séricas, gasometría, pruebas de función pancreática y estudio de necropsia. Los resultados fueron consistentes con insuficiencia pancreática exocrina secundaria a atrofia acinar pancreática.Relevancia clínica. La insuficiencia pancreática exocrina (IPE) es un síndrome caracterizado por la síntesis y secreción inadecuada de enzimas digestivas pancreáticas debido a un daño severo del órgano o falta de células acinares. Una de las causas más comunes es la atrofia acinar pancreática (AAP) en pacientes jóvenes como consecuencia de un trastorno genético complejo. La mayoría de los casos no demuestran signos clínicos evidentes hasta los doce meses de edad, por lo que el diagnóstico en etapas tempranas y el pronóstico no suelen ser favorables. Es necesario realizar un buen examen físico, varios exámenes de laboratorio y de imagen, para llegar al diagnóstico definitivo. El estudio y descripción de esta enfermedad es necesario para entender de mejor manera la fisiopatología, que permita realizar el tratamiento oportuno y mejorar así la calidad de vida de estos pacientes.Figura 2. Intestino y páncreas. Disminución marcada del tejido pancreático.
Avaliação da resistência da união imediata à dentina de sistemas adesivos simplificados
Authors: Portella Fernando Freitas , Collares Fabrício Mezzomo , Ogliari Fabrício Aulo , Fortes Carmen Beatriz Borges , Samuel Susana Maria Werner
Published: September 2019

Objetivo: Avaliar quatro sistemas adesivos comerciais de diferentes composições quanto ao desempenho da resistência da união à dentina.

Métodos: Vinte incisivos bovinos tiveram a dentina vestibular exposta e receberam restaurações de resina confeccionadas com quatro (n=5) diferentes sistemas adesivos simplificados: Magic Bond DE e OptiBond Solo (convencionais), One-Up Bond F e Adper Prompt L-Pop (auto-condicionantes). Os dentes foram seccionados perpendicularmente a interface adesiva utilizando-se um disco de diamante, de modo a se obter palitos de 1mm² de área de secção. Os palitos foram submetidos ao ensaio de micro-tração em uma máquina de ensaios universal. Os valores médios de resistência de união dos diferentes sistemas adesivos foram comparados utilizando-se ANOVA de uma via e teste Tukey, em um nível de significância de 5%.

Resultados: Os valores médios de resistência da união foram 48,81±0,56 para o Magic Bond DE, 47,52±13,03 para o OptiBond Solo, 44,68±13,32 para o One-Up Bond F e 31,59±11,81 para o Adper Prompt L-Pop. O adesivo Adper Prompt L-Pop apresentou resistência de união inferior a dos adesivos convencionais (p
ABORDAGEM INTEGRADA DE UM INCISIVO CENTRAL TRAUMATIZADO – RELATO DE CASO CLÍNICO
Authors: Severo Patrícia Inês Chaves , Totti Marcelo , Ferlini-Filho João , Dos Santos Regis Burmeister , Luisi Simone Bonato , Erhardt Maria Carolina Guilherme , Coelho-de-Souza Fábio Herrmann
Published: September 2019

OBJETIVO: O traumatismo alvéolo-dentário pode provocar uma série de consequências às estruturas coronária, radicular e tecidos adjacentes, estando na dependência das características do trauma. O objetivo do presente trabalho é apresentar um caso clínico de traumatismo com envolvimento endodôntico atípico seguido de reconstrução direta de resina composta associada a retentor intracanal estético. RELATO DE CASO: Paciente de 12 anos compareceu à clínica odontológica com sequelas de trauma recente nos dentes 21 e 22, sendo o 22 restaurado previamente de forma deficiente e o 21 com amplo comprometimento coronário e necessidade de tratamento endodôntico. O dente 21 apresentava 2 canais atípicos, mal formação corono-radicular e possível conduto lateral ou perfuração mesial. Após terapia endodôntica com obturação dos 2 canais e da perfuração ou canal lateral, foi cimentado um pino de fibra de vidro no canal principal seguido de reconstrução direta com resina composta. CONSIDERAÇÕES FINAIS: Através do planejamento proposto, obteve-se êxito na reabilitação do paciente, proporcionando a este saúde, forma, função e estética de modo conservador.
Influência do pré-condicionamento ácido em dentina na resistência de união imediata de sistemas adesivos autocondicionantes de dois passos
Authors: Leitune Vicente Castelo Branco , Collares Fabrício M , Paulus Marília , Augusto Carolina R , Samuel Susana Maria Werner
Published: September 2019

Objetivo: Avaliar a influência do pré-condicionamento da dentina com ácido fosfórico sobre a resistência de união de dois sistemas adesivos autocondicionantes de dois passos.

Métodos: Foram utilizados 32 incisivos bovinos, divididos aleatoriamente em 4 grupos. Os grupos receberam a aplicação dos sistemas adesivos autocondicionantesClearFil SE Bond (GCL) ou AdheSE (GAD). Dois grupos, GADpa e GCLpa, receberam, antes da aplicação do primer, o condicionamento com ácido fosfórico. Em cada dente foram confeccionados seis restaurações cilíndricas com área adesiva de 0,88 (± 0,03) mm2. Após 24 horas, os dentes foram submetidos ao ensaio de microcisalhamento, em uma máquina de ensaios universal, com uma velocidade de 1mm/min. A análise dos dados foi realizada com ANOVA de dois fatores a um nível de significância de 5%.

Resultados:Os valores médios de resistência de união variaram entre 16,25 e 21,71 MPa, entretanto não houve diferença estatisticamente significativa entre todos os grupos avaliados (p>0,05).

Conclusão: O condicionamento ácido da dentina não influenciou a resistência de união imediata dos dois sistemas adesivos autocondicionantes de dois passos.
PESQUISA QUALITATIVA NA SAÚDE BUCAL COLETIVA: UMA ANÁLISE BIBLIOMÉTRICA
Authors: Schaarschmidt Gabriela Messa , Bitencourt Fernando Valentim , Baumgarten Alexandre , Souza Juliana Maciel de , Toassi Ramona Fernanda Ceriotti
Published: September 2019

Introdução: Pesquisas qualitativas são utilizadas quando o objeto de pesquisa exige respostas que não se traduzem em números, sendo estruturada na experiência, na vivência, no senso comum e na ação. Busca a compreensão subjetiva das pessoas a respeito de sua vida diária. Objetivo: Analisar a produção científica em relação à pesquisa qualitativa na saúde bucal coletiva. Metodologia: Uma análise bibliométrica foi conduzida na base de dados da Biblioteca Virtual em Saúde com descritores controlados. Resultados: Foram avaliados 55 artigos publicados entre 1998-2013, observando-se um crescimento dessas publicações de 1998-2009 e desde então uma redução até 2013. O primeiro autor, em mais da metade dos artigos, era do Brasil, seguido pelo Reino Unido, Canadá e EUA. Esses autores estavam vinculados principalmente a instituições públicas. Os artigos, em sua maioria, foram publicados em periódicos de saúde pública e odontologia, incluindo dentistas, profissionais da saúde, pacientes/usuários de serviços de saúde e estudantes de odontologia, utilizando a técnica da entrevista. Destacam-se as pesquisas qualitativas com temáticas voltadas à Política de Saúde Bucal, Estratégia de Saúde da Família e Educação em Odontologia. A análise temática e a análise de conteúdo foram os métodos de interpretação mais utilizados nos estudos. Conclusão: Desafios importantes devem ser superados para a consolidação da pesquisa qualitativa na saúde bucal coletiva, o que inclui um maior número de artigos publicados, a apresentação dos aspectos éticos, financiamento para a realização das pesquisas qualitativa, vinculação com trabalhos acadêmicos e definição teórico-conceitual com o necessário fundamento epistemológico.
Centering ability, canal transportation and surface modifications of ProTaper F2 and F3 used in continuous rotation and reciprocating motion in curved root canals
Authors: Andreazza Jader Vinicius , Dos Santos Miguel Assis Martins , Pinheiro Lucas Siqueira , Iglesias Júlia Eick , Lopez Fernanda Ulmann , Grecca Fabiana Soares
Published: September 2019

Aims: To evaluate the centering ability, canal transportation and surface modifications of F2 and F3 ProTaper Universal (PT) instruments used in continuous rotation (CR) and reciprocating motion (RM) for the preparation of curved root canals. Material and methods: sixty mesiobuccal root canals of upper molars with curvatures between 25º and 35° were divided into three groups: I - PT in CR up to F3; II - PT in RM up to F3; III - F2 and F3 PT instruments in RM. Cone Beam Computed Tomography images were obtained before and after instrumentation. The scans were superimposed to determine the centering ability and canal transportation in apical, medium and cervical thirds. The apical 6 mm of the F2 and F3 files were evaluated under Scanning Electron Microscope before and after 1, 3 and 6 uses to assess distortion, surface wear and fracture. The statistical analysis of centering ability and canal transportation were performed by Kruskal–Wallis and ANOVA, respectively. The scores for deformation and surface wear were compared using ANOVA. Fisher’s exact test was used for the evaluation of instrument fracture. Results: there were no significant differences between groups regarding centering ability and canal transportation, as well as, for distortion, surface wear and fracture (p>.05). Conclusion: F2 and F3 instruments can be used for curved canals instrumentation. However, when used for entire canal preparation, F2 and F3 should be discarded after single use.