bluuebunny/crossref_metadata_2025 huggingface dataset:
Macronutrient Balance Implications from the DialBetesPlus Randomized Controlled Trial: A Secondary Analysis (Preprint)
Authors: Leung Nicholas , Enomoto Shunpei , Waki Kayo , Yamauchi Toshimasa , Nangaku Masaomi , Ohe Kazuhiko
Published: November 2023

BACKGROUND

Current mobile health interventions for type 2 diabetes mellitus promote lifestyle interventions, including diet and exercise. Challenges exist in accurately assessing caloric intake for diet-based interventions. In applications that target a reduction in BMI, there is a need for intervention targets other than total recorded calories.

OBJECTIVE

This analysis assesses the suitability of macronutrient percentages for use as target measurements in possible behavior modification interventions among obese Japanese adults with type 2 diabetes mellitus.

METHODS

We performed a secondary analysis of dietary data recorded via an mHealth application during the DialBetesPlus randomized controlled trial. We focused on a subset of patients in the intervention arm (n = 66), specifically obese patients (body mass index (BMI) over 25) with high meal recording rates (data recorded for at least three meals per day for at least 60% of days), yielding a subset of 20 patients (n = 20). To determine a suitable model to predict change in BMI and hemoglobin A1c (HbA1c), we conducted a multivariate analysis with candidate variables including step count, fat percentage, carbohydrate percentage, protein percentage, total calories, change in medications, change in self-monitoring score, baseline BMI, and baseline HbA1c.

RESULTS

Fat percentage of calories was the best single-variable determinant of change in BMI and HbA1c, with positive correlation with change in BMI (P = .03, adjusted R2 = 0.206) and change in HbA1c (P = .005, adjusted R2 = 0.330).

CONCLUSIONS

The correlation of fat percentage of calories with change in both BMI and HbA1c suggests that reducing the fat percentage of calories is a promising target for a behavior modification intervention seeking to reduce BMI and HbA1c levels.

CLINICALTRIAL

Trial Registration: University Hospital Medical Information Network Clinical Trial Register UMIN000033261.
Differential in Kidney Graft Years on the Basis of Solitary Kidney, Simultaneous Liver–Kidney, and Kidney-after-Liver Transplants
Authors: Schold Jesse D. , Mohan Sumit , Jackson Whitney E. , Stites Erik , Burton James R. , Bababekov Yanik J. , Saben Jessica L. , Pomposelli James J. , Pomfret Elizabeth A. , Kaplan Bruce
Published: November 2023

Background

The number of simultaneous liver–kidney (SLK) transplants has significantly increased in the United States. There has also been an increase in kidney-after-liver transplants associated with 2017 policy revisions aimed to fairly allocate kidneys after livers. SLK and kidney-after-liver candidates are prioritized in allocation policy for kidney offers ahead of kidney-alone candidates.

Methods

We compared kidney graft outcomes of kidney-alone transplant recipients with SLK and kidney-after-liver transplants using paired kidney models to mitigate differences among donor risk factors. We evaluated recipient characteristics between transplant types and calculated differential graft years using restricted mean survival estimates.

Results

We evaluated 3053 paired donors to kidney-alone and SLK recipients and 516 paired donors to kidney-alone and kidney-after-liver recipients from August 2017 to August 2022. Kidney-alone recipients were younger, more likely on dialysis, and Black race. One-year and 3-year post-transplant kidney graft survival for kidney-alone recipients was 94% and 86% versus SLK recipients 89% and 80%, respectively, P < 0.001. One-year and 3-year kidney graft survival for kidney-alone recipients was 94% and 84% versus kidney-after-liver recipients 93% and 87%, respectively, P = 0.53. The additional kidney graft years for kidney-alone versus SLK transplants was 21 graft years/100 transplants (SEM=5.0) within 4 years post-transplantation, with no significant difference between kidney-after-liver and kidney-alone transplants.

Conclusions

Over a 5-year period in the United States, SLK transplantation was associated with significantly lower kidney graft survival compared with paired kidney-alone transplants. Most differences in graft survival between SLK and kidney-alone transplants occurred within the first year post-transplantation. By contrast, kidney-after-liver transplants had comparable graft survival with paired kidney-alone transplants.
Textos en papel vs. textos electrónicos: ¿nuevas lecturas?
Authors: Vaca Uribe Jorge , Hernández y Hernández Denise
Published: November 2023

Este ensayo analiza semejanzas y diferencias entre los modos impresos y electrónicos del texto, por un lado, y sus lecturas concomitantes, por el otro. Reflexiona sobre las implicaciones de la propagación vertiginosa de los textos electrónicos en nuestras vidas y en nuestras prácticas como lectores, ponderando con detenimiento cuándo efectivamente se trata de textos o prácticas de lectura nuevas y cuándo es simplemente un cambio de soporte. De los análisis se desprenden algunos tópicos emergentes de investigación, tanto lingüísticos, como psicológicos y educativos. Se enfatizan algunas semejanzas, como el uso de un mismo sistema gráfico, la función referencial, etc. Entre las diferencias, se aborda la velocidad de transmisión, la accesibilidad y el alcance, la transportabilidad, la multimodalidad y la interactividad de algunos textos.
Una propuesta de cálculo de día solar local
Authors: Salinas-Carrillo José Enrique , Pérez-Castañeda Oscar Leopoldo , Arango-Perdomo Bonfilo Javier , López-Sánchez Eduardo
Published: November 2023

Un concepto propio de dispositivos que funcionan través de la irradiación solar directa es el concepto día local solar. En este artículo se revisa, la utilidad y la teoría del procedimiento para calcular las horas de este día cuando se recibe irradiación solar a un punto localizado en una superficie en un punto terrestre. Se aplica la óptica de medida de la inclinación de la sombra; condiciones locales definen la cantidad de irradiación solar que se recibe en un punto particular, se obtiene la duración del día a posteriori de la medición directa del ángulo de incidencia del haz de radiación solar, se determinan los valores observados para el 12 de septiembre 2020 en Tehuacán Puebla México; ángulo mínimo inicial fue de 36.33° y el ángulo mínimo final de 49.06°, y el ángulo máximo del día fue de 74.70°. Con esa concepción acorde con las mediciones de ángulo de inclinación de la radiación, se compara la hora horaria y la hora azimutal, bajo esta óptica se da una pausa del valor del ángulo durante 30 minutos de la hora pico, esto implicaría si medimos el tiempo en ese sistema que el tiempo se ha detenido.
Habilidades de pensamiento computacional en niños y niñas de las escuelas primarias utilizando tecnologías 4.0: un análisis bibliométrico
Authors: Cuesta-Quintero Byron , Duarte-Neira Wilder Andrés
Published: November 2023

El desarrollo digital ha facilitado el desarrollo de la educación en tecnología. Este trabajo analiza literatura científica sobre el impacto del pensamiento computacional en los niños. Este pensamiento formado desde la infancia permite utilizar la tecnología y desarrollar sistemas que gestionen soluciones a problemas. Cada día son más los científicos e instituciones educativas que hablan de este tema observando que temáticas enfocadas en la construcción de distinciones lógicas están siendo incluidas en los curriculum académicos con la finalidad de fortalecer conocimientos en esta materia. El objetivo es presentar un análisis de diferentes publicaciones relacionados al pensamiento computacional en la educación primaria; para este propósito los datos fueron recopilados desde la base de datos Scopus y analizados con el software de VOSviewer, se encontraron 625 resultados filtrados con la siguiente búsqueda: [computational  AND thinking]  AND  [children  OR  childhood], el análisis permite identificar autores más relevantes, países con mayor publicaciones, tasa de crecimiento anual, tipos de documentos, instituciones patrocinadoras, entre otros. Todos estos referentes científicos evidencian el incremento práctico y conceptual encontrado en el pensamiento computacional como una vía para la formación de las tecnologías de la información y comunicación en la educación infantil, logrando así una nueva alfabetización digital.
Investigating harms of testing for ovarian cancer - psychological outcomes and cancer conversion rates in women with symptoms of ovarian cancer: a cohort study embedded in the multicentre ROCkeTS prospective diagnostic study
Authors: Kwong Audrey , Kristunas Caroline , Davenport Clare , Aggarwal Ridhi , Deeks Jonathan , Mallett Sue , Kehoe Sean , Timmerman Dirk , Bourne Tom , Stobart Hilary , Neal Richard , Menon Usha , Gentry-Maharaj Alexandra , Sturdy Lauren , Ottridge Ryan , Sundar Sudha
Published: November 2023

Objectives: To investigate psychological correlates in women
referred with suspected ovarian cancer via the fast-track pathway,
explore how anxiety and distress levels change 12 months post-testing
and report cancer conversion rates by age and referral pathway.
Design: Single arm prospective cohort study Setting:
Multicentre. Secondary care including outpatient clinics and emergency
admissions. Participants: 2596 newly presenting symptomatic
women with a raised CA125 level, abnormal imaging or both.
Methods: Women completed anxiety and distress questionnaires at
recruitment and at 12 months for those who had not undergone surgery or
a biopsy within 3 months of recruitment. Main outcome measures:
Anxiety and distress levels measured using STAI-6 and IES-r
questionnaires. OC conversion rates by age, menopausal status and
referral pathway. Results: 1355/2596 (52.1%) and 1781/2596
(68.6%) experienced moderate-to-severe distress and anxiety at
recruitment. Younger age and emergency presentations had higher distress
levels. Clinical category for anxiety and distress remained
unchanged/worsened in 76% at 12 months despite a non-cancer diagnosis.
OC rates by age were 1.6% (95% CI 0.5 to 5.9) under 40 and 10.9 %
(95% CI 8.7 to 13.6) over 40 years. In women referred through
fast-track pathways, 3.3% (95% CI 1.9 to 5.7) of pre- and 18.5% (95%
CI 16.1 to 21.0) of postmenopausal women were diagnosed with OC.
Conclusions: Women undergoing diagnostic testing display severe
anxiety and distress. Younger women are especially vulnerable and should
be targeted for support. Women under 40 have low conversion rates and we
advocate reducing testing in this group to reduce harms of testing.
Optimization of Convolutional Neural Network models for spatially coherent multi-site fire danger predictions
Authors: Mirones Óscar , Baño-Medina Jorge , Cruz Mario Santa , Brands Swen , Bedia joaquin
Published: November 2023

The accurate prediction of the Fire Weather Index (FWI), a multivariate
climate index for wildfire risk characterization, is crucial for both
wildfire management and climate-resilient planning. Moreover, consistent
multisite fire danger predictions are key for targeted allocation of
resources and early intervention in high-risk areas, as well as for
“megafire” risk detection. In this regard, Convolutional Neural
Networks (CNNs) are known to capture complex spatial patterns in climate
data. This study compares different CNN architectures and traditional
Statistical Downscaling (SD) methods (regression and analogs) for
predicting daily FWI across diverse locations in Spain, considering
marginal, distributional and spatial coherence measures for validation.
Overall, the CNN-Multi-Site-Multi-Gaussian configuration, which
explicitly accounts for the inter-site variability in the output layer
structure, showed a superior performance. These insights provide a
methodological guidance for the successful application of CNNs in the
context wildfire risk assessment, enhancing wildfire response strategies
and climate adaptation planning.
Variable metaplastic entities in pleomorphic adenoma a review of a rare case report with a note on its significance
Authors: Mahapatra N. , Bhuyan L. , Chandra Dash , Mishra P.
Published: November 2023

Pleomorphic adenoma is the most common benign salivary gland neoplasm principally affecting the parotid gland of the salivary gland and the palate of the minor salivary gland. The term pleomorphic is assigned due to its varied histopathological presentation. We hereby describe a rare case of pleomorphic adenoma in a male patient in his 7th decade of life complaining of swelling in the hard palate for the past 3 years. This case report emphasizes the unique representation of squamous and lipomatous differentiation which was erroneously diagnosed as OSCC or mucoepidermoid carcinoma. We have also included a literature search of such cases that exhibited lipomatous and squamous differentiation in PA listed from the last 10 years.
Mettl3-Mediated m6A Methylation Controls Pancreatic Bipotent Progenitor Fate and Islet Formation
Authors: Sun Jiajun , Wang Yanqiu , Fu Hui , Kang Fuyun , Song Jiaxi , Xu Min , Ning Guang , Wang Jian , Wang Weiqing , Wang Qidi
Published: November 2023

The important role of m6A RNA modification in β-cell function has been established; however, how it regulates pancreatic development and endocrine differentiation remains unknown. Here, we generated transgenic mice lacking RNA methyltransferase-like 3 (Mettl3) specifically in Pdx1+ pancreatic progenitor cells and found the mice with the mutation developed hyperglycemia and hypoinsulinemia at age 2 weeks, along with an atrophic pancreas, reduced islet mass, and abnormal increase in ductal formation. At embryonic day 15.5, Mettl3 deletion had caused a significant loss of Ngn3+ endocrine progenitor cells, which was accompanied by increased Sox9+ ductal precursor cells. We identified histone deacetylase 1 (Hdac1) as the critical direct m6A target in bipotent progenitors, the degeneration of which caused abnormal activation of the Wnt/Notch signaling pathway and blocked endocrine differentiation. This transformation could be manipulated in embryonic pancreatic culture in vitro through regulation of the Mettl3-Hdac1-Wnt/Notch signaling axis. Our finding that Mettl3 determines endocrine lineage by modulating Hdac1 activity during the transition of bipotent progenitors might help in the development of targeted endocrine cell protocols for diabetes treatment.

Article Highlights
Enhancing control of air bubbles in water flows through laser-based surface wettability patterning
Authors: Mullennex Ryan , Huang Wuji , Harwood Casey , Buchholz James , Ding Hongtao
Published: November 2023

Air bubble injection has been a widely studied method for reducing frictional drag in fluid flows, especially in the marine industry. However, the lack of control over air bubble stability, size, and shape has hindered its widespread adoption. This study investigates the use of laser-based surface wettability modification techniques to address these challenges by enhancing control over air bubble behavior in water flows. We processed metal plates using nanosecond laser and chemical immersion to create wettability patterns consisting of regions of either superhydrophobicity or superhydrophilicity. Water tunnel experiments were conducted to observe the behavior of air bubbles over these different wettability patterns. The results revealed that surface wettability can be used to control the size and spatial distribution of air bubbles, which can enhance the energy cost-benefit of drag reduction methods in the marine industry. Moreover, this research offers new insights into the potential of laser-based surface wettability modification as a solution for improving the control of air bubble behavior in large-scale applications.
Funksjonsteori – en musikkteoretisk tradisjon
Authors: Utne-Reitan Bjørnar
Published: November 2023

Post-Riemannian function theory has held a strong position in Norwegian music education during the past fifty years. How has this tradition in Western music theory in general, and in Norway in particular, been historically constructed? The article provides a historical overview of (post-)Riemannian function theory, its pre-history and its reception. It does so based on the extensive literature on this topic in English-, German- and Scandinavian-language music research as well as central primary sources. In addition to providing the first survey of this literature in Norwegian, a central contribution of this article is to relate this field of research to the music theory context in Norway. The article discusses how Norwegian music theorists adopted function theory rather late (compared to, for instance, their Swedish and Danish colleagues) and how they preferred to adapt it in a manner that made the function symbols as similar to the older Roman numerals as possible. Drawing on the historical overview and the discussion of function theory in Norway, the final section of the article briefly addresses some general challenges with (post-)Riemannian function theory.
Foreword to the Ukrainian Translation of George Edward Moore's Article "The Refutation of Idealism"
Authors:   Lviv Polytechnic National University, Kozubenko Andrii , Perkhun Iryna ,   Lviv Polytechnic National University
Published: November 2023

In the foreword to the first Ukrainian translation of George Edward Moore's article “The Refutation of Idealism”, translators inform about his life and academic career, explain the impact of this article on the emergence of the analytical style of philosophizing, and the peculiarities of the translation.
Ángelo Néstore: una voz transgénero en el panorama poético actual
Authors: Medina Puerta Carmen
Published: November 2023

El objetivo de este ensayo es analizar la obra literaria de Ángelo Néstore a la luz del concepto de transgénero. Con este fin, en primer lugar, se desarrolla una explicación de la génesis y de la definición de transgénero, procedente de las teorías feministas y queer. A continuación, se exponen los efectos que tanto las teorías como los movimientos feministas y LGTBI han tenido en la realidad sociopolítica y jurídica de España. Finalmente, se dilucida la dimensión que tiene el concepto de transgénero en la producción lírica de Ángelo Néstore, la cual ocupa un lugar central en el panorama poético español del siglo XXI.
Gestión de calidad aplicada al turismo
Authors: Calderón-Fajardo Víctor , Para González Lorena
Published: November 2023

En el primer capítulo se aborda el concepto de gestión de calidad como un factor decisivo en el desarrollo y la competitividad de las empresas. Se hace hincapié en la gestión de la calidad, como un instrumento que posibilita a las empresas a que lleven a cabo procesos planificados, en los que se advierte sobre la manera de actuar frente a situaciones prototípicas. Contiene ejemplos concretos de la calidad programada, la calidad realizada y la calidad necesaria para que el alumno lo asimile de forma sencilla. Se centra igualmente, en la competitividad de un hotel con base al enfoque de Deming, en la implantación de un sistema de gestión por procesos para una oficina turística, en el modelo EFQM para hoteles y en el diseño de un sistema de gestión por procesos en un restaurante. En el segundo capítulo se tratan las diferencias entre una empresa de prestación de servicios respecto a una de producción de bienes. En las empresas de servicios el valor se encuentra en los elementos intangibles, los recursos humanos de la empresa y su interacción con el cliente, mientras que en las empresas de bienes existe un proceso de transformación que añade valor a los bienes que son tangibles. Por otro lado, se enumera de forma detallada las ventajas de un sistema de gestión de calidad en la restauración, se incluye un diagnóstico inicial para aplicar metodologías de calidad en un alojamiento, además de medidas para mejor la calidad de este servicio. Finalmente, se concluye con las herramientas para conocer la satisfacción y la fidelidad en el agroturismo, y con un ejemplo de cuestionario con las dimensiones de calidad del servicio que permiten abordar las mejoras necesarias para este establecimiento turístico. En el tercer capítulo se determinan las fases de implantación y certificación de un sistema de calidad en una organización turística (Modelo ISO 9001:2015). Se aporta un detallado ejemplo de la implantación del modelo de calidad medioambiental en una empresa de turismo activo. Se continúa con una pauta sobre cómo auditar de forma básica un hotel urbano. Se finaliza con la gestión de calidad en los destinos turístico, la descripción y la finalidad de la metodología SICTED, y con un pormenorizado ejemplo del Plan Estratégico en el municipio turístico de Sopela (Vizcaya).
Testing of Regulating and Non-Regulating Hydraulic Pumps
Authors: Kosiba Ján , Čurgaliová Gabriela , Tkáč Zdenko , Jablonický Juraj , Hanushchak-Yefimenko Liudmyla , Bukoros Tetiana
Published: November 2023

This article deals with the testing of regulating and non-regulating hydraulic pumps in laboratory conditions. The laboratory test was carried out on the hydraulic device consisting of two separate hydraulic circuits (for testing the non-regulating hydraulic pump and regulating hydraulic pump). A throttle valve or proportional throttle valve is used for loading. During the laboratory tests, the flow efficiency of the non-regulating hydraulic pump at rotation speed n = 1,500 rpm (nominal speed) was η
pp
= 98.91% (0 MPa) and η
pp
= 94.97% (20 MPa), and for the regulating hydraulic pump, the values were η
pp
= 97.57% (0 MPa) and η
pp
= 94.54% (20 MPa). The determined values of flow efficiency of hydraulic pumps determine the correct operation of the experimental hydraulic laboratory equipment.
The Prognostic Utility of Cytokines in Hospitalized COVID-19 Patients
Authors: Andrejkovits Ákos Vince , Huțanu Adina , Susányi Ervin József , Negrea Valentina , Văsieșiu Anca Meda
Published: November 2023

Introduction

The severity of COVID-19 relies on several factors, but the overproduction of pro-inflammatory cytokines remains a central mechanism. The aim of this study was to investigate the predictive utility of interleukin (IL)-6, IL-8, IL-10, IL-12, tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ) measurement in patients with COVID-19.

Material and Methods

We prospectively enrolled 181 adult patients with COVID-19 admitted to the 1st Infectious Disease County Hospital Târgu Mureș from December 2020 to September 2021. Serum cytokine levels were measured and correlated with disease severity, need for oxygen therapy, intensive care unit (ICU) transfer, and outcome.

Results

We found significantly higher serum levels of IL-6, IL-8, and IL-10 in patients with severe COVID-19 and in those with a fatal outcome. The logistic regression analysis showed a significant predictive value for IL-8 regarding disease severity, and for IL6 and IL-10 regarding ICU transfer and fatal outcome.

Conclusions

Serum levels of IL-6, IL-8, and IL-10 were significantly increased in patients with COVID-19, but their predictive value regarding disease severity and the need for oxygen therapy was poor. We found IL-6 and IL-10 to have a good predictive performance regarding ICU transfer and fatal outcome.
Monthly stream temperatures along the Danube River: Statistical analysis and predictive modelling with incremental climate change scenarios
Authors: Pekárová Pavla , Bajtek Zbyněk , Pekár Ján , Výleta Roman , Bonacci Ognjen , Miklánek Pavol , Belz Jörg Uwe , Gorbachova Liudmyla
Published: November 2023

The aim of the study is to analyse changes and predict the course of mean monthly water temperatures of the Danube River at various locations for the future. The first part of the study involves conducting a statistical analysis of the annual and monthly average air temperatures, water temperatures, and discharges along the Danube River. The study examines long-term trends, changes in the trends, and multiannual variability in the time series. The second part of the study focuses on simulating the average monthly water temperatures using Seasonal Autoregressive Integrated Moving Average (SARIMA) models and nonlinear regression models (NonL), based on two RCP based incremental mean monthly air temperature scenarios. To assess the impact of future climate on stream temperatures, the historical long-term average of the monthly water temperature (1990–2020) was compared with scenarios S1 (2041–2070) and S2 (2071–2100). The simulation results from the two stochastic models, the SARIMA and NonL, showed that in scenario S1, the Danube River’s average monthly water temperature is projected to increase by 0.81/0.82°C (Passau), 0.55/0.71°C (Bratislava), and 0.68/0.56°C (Reni). In scenario S2, the models predict higher increases: 2.83/2.50°C (Passau), 2.06/2.46°C (Bratislava), and 2.52/1.90°C (Reni). Overall, the SARIMA model proved to be more stable and effective in simulating the increase in monthly water temperatures in the Danube River.
Impact of biochar particle size and feedstock type on hydro-physical properties of sandy soil
Authors: Botková Natália , Vitková Justína , Šurda Peter , Massas Ioannis , Zafeiriou Ioannis , Gaduš Ján , Rodrigues Francisco Cota , Borges Paulo Filipe Silva
Published: November 2023

Biochar, as an organic amendment, could positively change soil properties, especially soil with low organic matter and/or poor structure. Biochar application in sandy soil with low organic matter could be an effective tool for improving hydro-physical parameters of the soil economically and ecologically as well. The effect on bulk density, particle density, porosity, saturated hydraulic conductivity and available water content for plants of two biochar types applied at three different particle sizes in a sandy soil was examined. The results confirmed previous studies, showing decreased bulk density, particle density and saturated hydraulic conductivity and partially increased available water content for plants and porosity. Both biochar type and particle size affected the studied soil hydro-physical parameters. After analysis and comparison of two different types of biochar and three particle sizes, the most effective treatment for sandy soil was proved by the biochar produced from willow with the smallest particle size (<125 µm).
Using feature engineering and machine learning in FAO reference evapotranspiration estimation
Authors: Považanová Barbora , Čistý Milan , Bajtek Zbyněk
Published: November 2023

The authors of this study investigated the use of machine learning (ML) and feature engineering (FE) techniques to accurately determine FAO reference evapotranspiration (ETo) with a minimal number of climate variables being measured. The recommended techniques for areas with insufficient measurements are based solely on daily temperature readings. Various ML methods were tested to evaluate how sophisticated an ML algorithm is for this task necessary. The main emphasis was on feature engineering, which involves converting raw variables into inputs better suited for ML algorithms, resulting in improved results. FE methods for estimating evapotranspiration include approximations of clear-sky solar radiation based on altitude and Julian day, approximate relative humidity and wind velocity, a categorical month variable, and variables interactions. The authors confirmed that the ability of ML in such tasks is not solely dependent on choosing the suitable algorithm but also on this frequently ignored step. The results of computational experiments are presented, accompanied by a comparison of the proposed method against standardEToempiric equations. Machine learning methods, mainly due to the transformation of raw variables using FE, provided better results than traditional empirical methods and sophisticated ML algorithms without FE. In addition, the authors tested the applicability of the developed models in the broader area to evaluate the possibility of their generalizability. The potential of this approach to deliver improved predictions, reduced input requirements, and increased efficiency holds interesting promise for optimizing water management strategies, irrigation planning, and decision-making within the agricultural sector.
Lost in Broadcasting: League of Nations, International Broadcasting and Swiss Neutrality
Authors: Khodnev A. S.
Published: November 2023

The article delves into the historical context of cross-border radio broadcasting during the 1930s by the League of Nations (LN) and the significant impact of Switzerland's neutrality as the host country on this international organization. Drawing from the recently digitized and accessible LN archive in Geneva, this narrative unveils a minor conflict of interest that evolved into a notable political crisis, marking an international legal precedent by showcasing the influence wielded by a smaller host nation upon a global organization. The architects of the League of Nations envisioned Geneva as an ideal hub for the organization's activities, complete with modern communication technologies for global outreach. However, Switzerland's neutral stance posed an obstacle to the establishment of the League's radio broadcasting infrastructure. Recognizing the absence of robust emergency communications, transport links, and the absence of a dedicated radio station in Geneva during the mid-1920s, the LN sought an agreement with the Radio-Swiss station. Consequently, the LN's own radio station, Radio-Nations, commenced broadcasting on February 2, 1932, coinciding with the start of the Conference on the Reduction and Limitation of Arms. By May 1938, amidst mounting tensions in Europe, Switzerland chose to assert complete neutrality within the League. Discussions within the Federal Council revolved around the possibility of suspending the agreement made on May 21, 1930, along with the support for Radio-Nations. Unexpectedly, on November 3, 1938, the LN leadership in Geneva expressed a desire to re-evaluate the 1930 convention. The outbreak of World War II drastically reshaped the relationship between the LN and Radio-Nations. Switzerland decided against entering into a new agreement with the LN, leading to the closure of Radio-Nations on February 2, 1942. Maintaining the nation's neutrality, the Swiss government vigilantly observed the unfolding events during the war. During the peak of Nazi Germany's advances, Bern adopted stringent measures against the LN, upholding a resolute diplomatic stance. However, the Swiss stance toward the LN and the division of Radio-Nations’ ownership gradually shifted from 1943, culminating in the resolution of several financial matters. Ultimately, in 1947, the LN's liquidation commission transferred the remaining assets of Radio-Nations and its radio waves to the United Nations.
The Studies of the Novo-Ufa Burial Ground in 2000
Authors:   Institute of History, Language and Literature of the Ufa Federal Research Center of the Russian Academy of Sciences. October Av., 71, Ufa, 450054, Republic of Bashkortostan, Russian Federation, Ovsyannikov Vladimir V.
Published: November 2023

The article publishes the results of rescue excavations of a small area (about 47 m2) Novo-Ufa burial ground. The description of the burial rite and inventory of 12 burials is given. Weapons, household items and jewelry were found in the graves. Two groups of burials were identified in the investigated area. One group of burials dates back to the II–I centuries BC. The date is established by the presence of bronze arrowheads and eight-shaped buckles in the burial complexes. The second group of burials is attributed to the I century BC – I century AD. The chronological position of this group is determined by the presence of iron arrowheads, buckle with a movable tongue and bronze diamond-shaped belt pads in the graves. Thanks to the research of 2000, ideas about the territory of the Novo-Ufa burial ground have changed. The area of the necropolis has almost doubled. New chronological boundaries of the monument have also been installed: IV century BC – I century AD.
ΦΙΛΙΣΚΟΣ Ο ΜΑΧΙΜΟΣ (to the Interpretation of the Graffito from Myrmekion)
Authors:   The Saint Petersburg Institute of History Russian Academy of Science. Petrozavodskaya st., 7, Saint Petersburg, 197110, Russian Federation, Bekhter Anastassia P.
Published: November 2023

The article publishes an ostracon with a two-line graffito found during the excavations of the Myrmekion settlement, dating from the II-I centuries BCE. The inscription on the shard Φιλίσκος ὁ μάχι|μος, which is most likely a private one (marking?), can be interpreted in two ways. In the first case, ὁ μάχιμος is interpreted in the broad meaning of 'warrior, fighter', representing a playful nickname of Philiskos, in the second – in a highly specialized one, used as a designation for foreign mercenaries in the Egyptian army of the Ptolemaic era. The involvement of documents fixing the presence of immigrants from the Bosporus in the Ptolemaic army allows us to consider the second reading option as quite possible. The graffito in question gives an occasion to turn once again to the interpretation of the lines 1-2 of CIRB 450 proposed by the author: Δολης ὁ [[Ἡ]]γοῦμεν|oς, which was seriously criticized by V.P. Yailenko. The analysis of the argument of an opponent reveals its inconsistency, and allows you to draw an interesting parallel between Δολης ὁ [[Ἡ]]γοῦμενος and Φιλίσκος ὁ μάχιμος in the first understanding of the graffito.
Early Neolithic of the Middle Don in the Light of Current Research (based on materials from the Cherkasskaya-5 site)
Authors:   SPC “Voronezh Archaeological Society”. Pilot Kolesnichenko Street, 23, Voronezh, 394052, Russian Federation, Skorobogatov Andrei M. , Dolbunova Ekaterina V. ,   State Hermitage. Dvortsovaya Naberezhnaya (Embankment), 34, Saint Petersburg, 190 000, Russian Federation, Roslyakova Natalia V. ,   Samara State University of Social Sciences and Education. M. Gorkogo St., 65/67, Samara, 443099, Russian Federation, Gasilin Vyacheslav V. ,   Institute of Plant and Animal Ecology, Ural Branch of the Russian Academy of Sciences. St. March 8, 202, Ekaterinburg, 620144, Russian Federation
Published: November 2023

The article deals with the latest overview of the Early Neolithic site Cherkasskaya-5, located in the Middle Don, southern part of the forest-steppe zone, Voronezh Oblast. The site is characterized by particular preservation of organic remains and a range of materials available for dating, which is rare for sites of the Don forest-steppe area. The first radiocarbon dates, along with particular early Neolithic flint assemblage, allowed attributing the complex to the early Neolithic. First archaeozoological analysis suggested the presence of bones of domesticated species. However recent re-examination of the faunal collection did not allow identifying any domesticated species. New AMS-radiocarbon dates made on organic crust and animal bones confirmed the Early Neolithic age of the site. Direct dating of the organic wrapping of a Cretaceous sinker allowed refining the age of the early Neolithic period to the first quarter of the 6th mill BC. Excavations conducted in 2014–2015 allowed obtaining a ceramic collection, which does not have any analogies within the surrounding Neolithic sites of the Middle and Upper Don region, and finds more similarities with Lower Volga ceramic tradition. It allows us to put a new glance at the process of Neolithisation of the region.
„Meine Zeit hat sich verändert!“
Authors: Paravicini Annina
Published: November 2023

Die Arbeit stellt eine gekürzte Form einer Prozessanalyse dar. Es wird die mehrjährige Therapie mit einer zu Beginn der Therapie 10½-jährigen Klientin mit Todesängsten, massiven Gefühlsausbrüchen und Kontrollzwängen nachgezeichnet und versucht, den Prozess zu erfassen, wie ihn die Therapeutin erlebt hat. Die Therapeutin war durch ihre personzentrierte Haltung stets bemüht, mit der Klientin so in Kontakt zu sein, dass diese sich in ihrem Erleben frei entfalten konnte und unterstützte so deren Selbstexploration. Sie verließ sich dabei vor allem auf die Aktualisierungstendenz und verzichtete bewusst auf gezieltes, technikgeleitetes Eingreifen, bot lediglich Spielmaterial zur Unterstützung der Symbolisierung des Erlebens. Es wird sichtbar, wie die Klientin in der Spieltherapie ihre innere Welt kennenlernt, indem sie sich ihrem inneren Erleben, ihren Bedürfnissen, Sehnsüchten, Enttäuschungen annähern kann und beginnt, sich behutsam mit diesem Erleben auseinanderzusetzen. Gleichzeitig zeigt die Arbeit, wie personzentrierte Spieltherapie ganz konkret vor sich geht. Die Namen der Personen und weitere Angaben, die Rückschlüsse auf die Klientin zulassen könnten, wurden geändert.
STUDENTS’ ENGAGEMENT IN VIRTUAL CREATIVE WRITING: DEVELOPING A CREATIVE WRITING STYLE
Authors: Surfaifel Fety , Emilia Emi , Gunawan Wawan
Published: November 2023

Writing is not a stand-alone mental activity; it is inextricably linked to other forms of creative design, such as drawing and music composition. Writing is a highly sought-after skill in today's digital world. Creative writing is defined as the fluent exchange of concepts in an original manner through the construction of logical connections between them in written form based on the individual's schema. This article discusses a study that examined factors affecting student engagement as a lens through which to examine students' perceptions of their creative writing class participation. These interactions emphasize the complexities of student engagement and promote the accuracy of the instruments and metrics used to study it. Cognitive engagement is concerned with a student's internal investment in the learning process, which includes inner psychological characteristics or nonvisible characteristics that encourage effort in acquiring, comprehending, and mastering the knowledge or skills required for academic work. As a result, English lessons were held for 12 students from Flores' private junior high school. They completed a questionnaire that included quantitative and qualitative questions. Descriptive statistics are used to examine qualitative data conceptually and statistically. The participants' experiences reflected various aspects of the students' participation. According to the findings, creative writing activities can help students learn about behavior, emotion, and cognition in a poetry class. However, in a poetry class, emotional involvement prevailed and was followed by behavioral engagement. Nonetheless, pupils maintained a low level of cognitive engagement.
STUDYING THE EFFECT OF TH-232 ON BIOLUMINESCENT CELLULAR SYSTEMS. THE ROLE OF REACTIVE OXYGEN SPECIES
Authors:   Institute of Biophysics SB RAS, Krasnoyarsk, Kolesnik O.V. , Rozhko T.V. , Sachkova A.S. , Kudryasheva N.S. ,   Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University,   Tomsk Polytechnic University,   Siberian Federal University, Krasnoyarsk
Published: November 2023

Despite the prevalence of thorium in the ecosystem its effect on living organisms has not been studied. Marine luminescent bacteria is an optimal bioassay for studying the effects of low-dose thorium exposure. We observed activation of bioluminescence under low-dose exposures (< 0.01 Gy) and decay of the content of reactive oxygen species in the bacterial suspensions.
IN VIVO STUDY OF THE OXYGEN AND METABOLIC STATUS OF TUMORS DURING ANTI-TUMOR THERAPY USING THE PLIM/FLIM METHOD
Authors:   Privolzhsky Research Medical University, Nizhny Novgorod, Komarova A.D. , Sinyushkina S.D. , Mozherov A.M. , Kritchenkov I.S. , Tunik S.P. , Druzhkova I.N. , Shcheslavskiy V.I. , Shirmanova M.V. ,   Lobachevsky State University of Nizhny Novgorod,   Saint Petersburg State University
Published: November 2023

The paper presents the results of a study of the oxygen and metabolic status of tumors in in vivo models using time-resolved PLIM/FLIM microscopy. The possibility of simultaneous assessment of the oxygen status of tumors in vivo using a new phosphorescent sensor based on iridium and the metabolic status by autofluorescence of the NAD(P)H cofactor was shown for the first time, and changes were demonstrated against the background of antiangiogenic therapy.
BIOPRINTING WITH XANTHAN GUM HYDROGEL CONTAINING CARBON NANOTUBES
Authors:   Fyodorov Eye Microsurgery Federal State Institution, Krasnodar, Kravchenko S.V. ,   Kuban State Technological University, Krasnodar
Published: November 2023

Bioprinting is a perspective method of tissueengineered constructions fabrication for regenerative medicine and physiological processes modelling. This study presents brief results of experiments on bioprinting with xanthan gum hydrogel containing carbon nanotubes.
LU0.85GD0.15F3 NANOPARTICLES AS NEW THERANOSTICAGENT FOR RADIATION THERAPY
Authors:   Institute for Theoretical and Experimental Biophysics RAS, Pushchino, Mysina E.A. , Ivanov V.K. , Kolmanovich D.D. , Popov A.L. ,   Kurnakov Institute of General and Inorganic Chemistry RAS, Moscow
Published: November 2023

Here, we have proposed a new type of lutetium fluoride based nanoradiosensitizer based, which have radiosensitizing activity and T1 MRI imaging.
OXOG:C AND OXOG:A BASE PAIR OPENING DYNAMICS BY NMR MAGNETIZATION TRANSFER FROM WATER
Authors:   Vorozhtsov Institute of Organic Chemistry SB RAS, Novosibirsk, Ovcherenko S.S. , Nasonov D.M. , Shernyukov A.V. , Endutkin A.V. , Zharkov D.O. , Bagryanskaya E.G. ,   Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk,   Novosibirsk State University
Published: November 2023

We adapted the CLEANEX-PM NMR protocol to detect DNA imino proton exchange with water protons and analyze the opening dynamics of base pairs containing 8-oxoguanine (oxoG): oxoG:C, oxoG:A and pairs G:C, G:A in model DNA duplexes. According to our data, the oxoG:C pair did not open easier than G:C, arguing against extrahelical base capture by Fpg/OGG1. In the oxoG:A mispair the equilibrium is shifted by 3−4 orders of magnitude toward the open state and we hypothesize oxoG extrahelical recognition by MutY/MUTYH.
FLORA OF URBAN SETTLEMENS OF COAST SOVETSKAYA GAVAN BAY (Khaba rovsk Territ ory)
Authors:   Federal State-Funded Institution «Zapovednoe Priamurye», Shcheglova I.P.
Published: November 2023

An annotated list of 694 vascular plant species identified within the administrative boundaries of four urban settlements: Sovetskaya Gavan, Lososina, Maysky and Zavety Ilyicha, located on the coast of Sovetskaya Gavan Bay are given. Data on species habitats, frequency of occurrence, as well as biomorphological, ecological and chorological analyzes of the flora are given.
Holographic sound fields shape 3D matter without a touch
Authors: Melde Kai
Published: November 2023

Sound fields exert forces on particles suspended in liquids - seemingly without contact. Control over the sound pressure in 3D lets us create force landscapes, where microparticles can be remotely pushed to form larger objects in a single step. We developed the acoustic hologram, a technology that enables such control over ultrasound fields and which shows promise for a new type of biofabrication.
A comparative study of the antiarrhythmic activity of anxiolytics, benzodiazepine and benzimidazole derivatives in a model of electrical ventricular fibrillation
Authors: Столярук В.Н. , Вититнова М.Б. , Цорин И.Б. , Крыжановский С.А. , Середенин С.Б.
Published: November 2023

Цель исследования – сравнительное изучение антиаритмической активности фабомотизола и производных бензодиазепина (феназепама и диазепама) на модели электрической фибрилляции желудочков сердца у крыс с интактным и денервированным миокардом. Методика. В экспериментах на интактных крысах и крысах с денервированным миокардом в сравнительном аспекте изучена антиаритмическая активность анксиолитиков – производных бензодиазепина (феназепама и диазепама) и бензимидазола (фабомотизола). Результаты. Показано, что феназепам (1,0 мг/кг, в/в) и фабомотизол (7,5 мг/кг, в/в) у интактных животных, в отличие от диазепама (0,5 и 1,0 мг/кг в/в), статистически значимо (р=0,028) повышают порог электрической фибрилляции желудочков сердца. У животных с денервированным миокардом только фабомотизол проявлял противофибрилляторную активность (p<0,05). Заключение. Таким образом, анксиолитики фабомотизол и феназепам проявляют выраженную антиаритмическую активность, однако феназепам реализует свою антиаритмическую активность преимущественно на уровне ЦНС, а фабомотизол – на уровне кардиомиоцитов.

Aim. To compare the antiarrhythmic activity of fabomotizole and benzodiazepine derivatives (phenazepam and diazepam) in electrical ventricular fibrillation modeled in rats with intact and denervated myocardium. Methods. In experiments on intact rats and rats with denervated myocardium, the antiarrhythmic activity of the anxiolytics, benzodiazepine (phenazepam and diazepam) and benzimidazole (fabomotizole) derivatives, was compared. Results. It was shown that phenazepam (1.0 mg/kg, i.v.) and fabomotizole (7.5 mg/kg, i.v.) administered to intact animals, in contrast to diazepam (0.5 and 1.0 mg/kg, i.v.), significantly (p=0.028) increased the electrical ventricular fibrillation threshold. In animals with denervated myocardium, only fabomotizole showed an antifibrillatory activity (p<0.05). Conclusion. It can be assumed that phenazepam implements its antiarrhythmic activity mainly at the level of the central nervous system whereas fabomotizole produces it at the level of the myocardium.
BigBind: Learning from Nonstructural Data for Structure-Based Virtual Screening
Authors: Brocidiacono Michael , Francoeur Paul , Aggarwal Rishal , Popov Konstantin , Koes David , Tropsha Alexander
Published: November 2023

Deep learning methods that predict protein-ligand binding have recently been used for structure-based virtual screening. Many such models have been trained using protein-ligand complexes with known crystal structures and activities from the PDBBind dataset. However, because PDBbind only includes 20K complexes, models typically fail to generalize to new targets, and model performance is on par with models trained with only ligand information. Conversely, the ChEMBL database contains a wealth of chemical activity information but includes no information about binding poses. We introduce BigBind, a dataset that maps ChEMBL activity data to proteins from the CrossDocked dataset. BigBind comprises 583K ligand activities and includes 3D structures of the protein binding pockets. Additionally, we augmented the data by adding an equal number of putative inactives for each target. Using this data, we developed BANANA (BAsic NeurAl Network for binding Affinity), a neural network-based model to classify active from inactive compounds, defined by a 10 μM cutoff. Our model achieved an AUC of 0.72 on BigBind’s test set, while a ligand-only model achieved an AUC of 0.59. Furthermore, BANANA achieved competitive performance on the LIT-PCBA benchmark (median EF1\% 1.81) while running 16,000 times faster than molecular docking with GNINA. We suggest that BANANA, as well as other models trained on this dataset, will significantly improve the outcomes of prospective virtual screening tasks.