bluuebunny/crossref_metadata_2025 huggingface dataset:
So Similar, Yet So Different: Russia and Turkey in the Western Balkans – The Case of Serbia
Authors: VUKSANOVİC Vuk
Published: May 2023

In recent years, Russia and Turkey have been among non-Western powers that have been more assertive in their foreign policies in the Western Balkans. Naturally, this creates the need to identify the key similarities and differences between these two geopolitical players. By using the case of Serbia, the pivotal country of the Western Balkans and a country whose foreign policy was largely influenced by the idea of hedging and engaging non-Western players, one can determine key similarities and differences between these two powers. This paper states two major similarities between these two powers and one major difference. The first similarity is that both Russia and Turkey are acting based on the same permissive environment of a regional power vacuum, the environment in which the EU’s leverage has decreased and in which countries like Serbia feel emboldened to hedge their bets and diversify partnerships. The second similarity is that although the popular explanation is to stress to powers’ ethnic and religious ties with the Balkans, Slavic and Orthodox ties in case of Russia and Islam in case of Turkey, or even as the continuation of old imperial traditions, the two countries are guided by strategic pragmatism. The difference between the two powers is that Russia can be defined as a status quo power as it aims to act as a spoiler perpetuating the current state of political dysfunctions; Turkey is not a status quo player as it does not oppose the region’s membership in Western institutions as long as its interests are respected.
TREN PERKEMBANGAN PENELITIAN AKUNTANSI HIJAU: SYSTEMATIC LITERATURE REVIEW
Authors:   Universitas Hasanuddin Indonesia, Paledung Marannu , Nurdiyanti Desi ,   Universitas Hasanuddin Indonesia, Damayanti Ratna Ayu ,   Universitas Hasanuddin Indonesia, Said Darwis ,   Universitas Hasanuddin Indonesia
Published: May 2023

Research Purposes: This study aims to review the information that has existed in previous studies because the concept of Green Accounting (GA) in Indonesia is still in the growth stage and as a basis for scientific development and can provide ideas related to new topics in the future. Research Methods: This research used the systematic literature review (SLR) method and a total of 47 articles accredited with SINTA was analyzed in this study. Research Results and Findings: The development trend of the number of publications related to Green Accounting is still fluctuating from 2012 to 2022. The most used research method is quantitative research. The most widely used instruments in collecting data in such studies mainly used documentation techniques. And analyze the most widely used data is the multiple regression method. The overall research series related to the implementation of GA in Indonesia is quite good but needs improvement because there has not been much research and limited topics. This research has implications for environmental management actions, and efforts based on environmentally friendly principles or green innovation can continue to increase.
PENGGUNAAN ENERGI TERBARUKAN, SKOR ESG, BIAYA MODAL DAN BIAYA OPERASIONAL PADA KINERJA KEUANGAN
Authors:   Universitas Ciputra Surabaya Indonesia, Vlaviorine Emelie , Widianingsih Luky Patricia ,   Universitas Ciputra Surabaya Indonesia
Published: May 2023

Research Purposes. The purpose of this study is to see the effect of financial performance through ROA which is proxied into 5 variables, namely the use of renewable energy, ESG scores, capital costs, and operational costs. Research Methods. The population in this study is the Asian mining industry registered at Refinitiv using a purposive sampling method using 165 samples during 2019- 2020. Data collection uses secondary data that comes from the Refinitiv web. Data analysis used multiple linear regression using SPSS version 26. Research Results and Findings. The results of the study proved that the ESG score and cost of capital variables had a positive effect on financial performance. Meanwhile, the variable use of renewable energy and operational costs has a negative effect on finan- cial performance.
PENGARUH PENERAPAN PSAK 72 DAN PSAK 73 TERHADAP KINERJA KEUANGAN
Authors:   Universitas Katolik Widya Mandala Surabaya Indonesia, Lestari Mei Lin Teja Dwi
Published: May 2023

Research Purposes. The purpose of this study is to determine the impact of the adoption of PSAK 72 and PSAK 73 on the financial performance of IDX non-financial companies in 2019-2021. Research Methods. As the source of the data extracted is secondary data on financial statements of non-financial companies listed on the Indonesian Stock Exchange in 2019-2021, this study uses quantitative methods. Research Results and Findings. Based on the test results, it shows that the value of the independent variables PSAK 72 and PSAK 73 on the company's financial performance is insignificant. The results of this study found that PSAK 73 has no significant effect on financial performance. For the control variable, the company's size showed a sig value close to significant, namely 0.065 to NPM's financial performance and 0.092 to ROE's financial performance. Industrial type control variables show insignificant value to financial performance. As a result of the analysis and discussion on the impact of the adoption of PSAK 72 and PSAK 73 on financial performance, it can be concluded that the adoption of PSAK 72 and PSAK 73 will not affect the financial performance of the company. The study results open opportunities for further research on the relevance of changes in accounting standards on financial performance.
Challenges of quantifying direct heat stress effects of climate change on seabirds
Authors: Oswald SA , Arnold JM
Published: May 2023

The importance of heat stress as a consequence of climate climate change is often overlooked for seabirds. As endotherms, seabirds must actively thermoregulate at temperatures above their thermoneutral zone, or risk lethal hyperthermia. Although essential activities (e.g. foraging, breeding) may be traded off for thermoregulatory behaviors during periods of heat stress, a recent report by Olin et al. (2024; Mar Ecol Prog Ser 737:147-160 in this Theme Section) is one of very few that directly link this to demography. We argue that heat stress effects, which have strong theoretical support, are underreported directly because large-scale mortality events are rare, and small-scale events are hard to identify and easily obscured by indirect trophic effects. Quantifying heat stress effects on seabirds is necessary to understand fully the threats from climate change but requires prioritizing research in the following areas: developing methods to attribute heat mortality, determining baseline levels of heat mortality, elucidating ecological and organismal differences that underlie heat stress sensitivity, investigating the importance of possible sublethal mechanisms, and separating heat stress trade-offs from indirect effects of climate.
Cutaneous Squamous Cell Carcinoma of the Hand Presenting as Clinical Perineural Invasion
Authors: Sarsam Sera , Gunatheesan Shyamalar , Mann Nigel
Published: May 2023

Cutaneous squamous cell carcinoma of the hand with clinical perineural invasion is uncommon. This article describes a case of a 70-year-old female who presented with a small painful nodule on the dorsum of the left hand with minor skin surface changes who underwent excisional biopsy. A deep long subcutaneous cord was palpable extending proximally from the nodule. Intraoperative findings showed a tumour growing 2.5 cm along the dorsal cutaneous nerve of the hand, and histopathological examination revealed a primary well-differentiated squamous cell carcinoma with perineural invasion. This case highlights the importance of considering malignancy as a differential diagnosis when dealing with atypical lesions.
LITERATURE REVIEW GAMBARAN TERAPI PLASSMA KONVALESEN UNTUK PASIEN COVID-19
Authors: Supadmi Francisca Romana Sri , Sinaga Yossi Pramita , Yuni Astuti Tyas Ning
Published: May 2023

Latar belakang COVID-19 merupakan penyakit yang disebabkan oleh Severa Acute Respiratory Syndrome Coronavirus2 (SARS-CoV-2). SARS-CoV-2 memiliki laju mutasi yang tinggi sehingga karakteristik virus berubah-ubah menyebabkan virus yang sama memiliki sifat baru. Terapi plasma konvalesen (PK) merupakan terapi dengan menggunakan plasma yang berasal dari pasien COVID-19 yang telah pulih. Hasil dari pelaksanaan terapi PK sangat dipengaruhi oleh produk terapi yang digunakan dan kriteria pasien yang menerima terapi PK. Sehingga peneliti ingin mengetahi gambaran terapi PK untuk pasien COVID-19 dengan studi literature review. Tujuan: untuk mengetahui gambaran terapi plasma konvalesen untuk pasien COVID-19. Metode penelitian literature review. Hasil Penelitian: Terdapat perbedaan dan persamaan pada kriteria pendonor PK dan pasien penerima PK dari jurnal. Sedangkan pada hasil pemberian PK dari jurnal menunjukan hasil yang sama. Kesimpulan: Kriteria pendonor PK yaitu pasien COVID-19 yang telah pulih, tidak muncul gejala selama 14 hari, , negative antibody HLA, memiliki antibody IgG dan IgM terhadap SARS-CoV-2, serta memenuhi syarat standar donor darah. Kriteria pasien penerima PK yaitu pasien COVID-19 yang memiliki gejala berat dan mengancam jiwa, IgA normal, GCS ?12, GFR ?30, dan tidak ada hipertensi tidak terkendali. Serta, hasil dari pemberian PK menunjukan perbaikan gejala klinis dan angka kematian yang lebih kecil pada pasien penerima PK.
ANALISIS MANAJEMEN RISIKO DENGAN METODE HIRADC PADA INDUSTRI MEUBEL UD. ULUM JAYA
Authors: Dermawan Muhammad Ilham Rizqi , Sahri Moch
Published: May 2023

The International Labor Organization (ILO) explained that 2.78 million workers die every year due to work accidents and occupational diseases. Around 2.4 million (86.3%) of these deaths were due to occupational diseases, while more than 380,000 (13.7%) were due to work accidents. Community groups working in the informal sector have not yet received attention in the field of Safety and Health. the Occupational Health. The furniture industry is one of the informal industries that has a high level of complexity. This industry is an informal industry using wood as the basic material, where the process produces a lot of wood fibers or very small dust in the work environment. In a total time of approximately 10 working hours, workers are exposed to dust and other work hazards, this causes work accidents and occupational diseases, to reduce or eliminate hazards that can cause accidents in the workplace, a risk management is needed. requirements of OHSAS 18001 clause 4.3.1 that the organization must establish procedures and carry out hazard identification, risk assessment and determining control. The results of the study show that the work process that has the highest risk is in the formation process work unitKeywords: Occupational Safety and Health, Meubel Industry, HIRADC
Dampak Pandemi COVID-19 Terhadap Kualitas Pelayanan dan Pengelolaan Keuangan di Rumah Sakit
Authors: Puspita Sari Indah Mutiara
Published: May 2023

ABSTRACTThe COVID-19 pandemic has an impact on economic growth, the restrictions imposed also have a negative impact on hospital revenues, resulting in hospitals depending on financing and financial support which can also cause hospital services to be less than optimal. In addition, a heavy workload is also the factor that has the most negative impact on the quality of health services. This literature review starts from topic selection, keyword selection, to searching for journal references from several sources, namely Pubmed and Google Schoolar. The keywords used are services quality impact, economy impact, hospital, during the COVID-19 pandemic. Based on the search results, there were 276 articles which were then selected for up to 6 articles that were included in the discussion. The results of this study are the COVID-19 pandemic has an impact on the economy and operations of the country and the health care system as well as the quality of services in hospitals. The decrease in visitors resulted in hospitals cutting revenue from services so that it could disrupt patient care. The pressure that occurred and the isolation because many health workers were exposed to Covid-19 also caused the quality of service at the hospital to deteriorate.Keyword : Services Quality Impact, Economy Impact, Hospital, COVID-19 Pandemic
Gambaran tingkat kepuasan pasien terhadap pelayanan kefarmasian pada era globalisasi di klinik utama “X” Kota Semarang.
Authors: WS FX Sulistiyanto , Anggoro Aloysius Barry , . Erwin Indriyanti
Published: May 2023

Pharmaceutical services are the main support in every health facility and are part of health services that aim to increase the rational, safe and efficient use of drugs in order to achieve an increase in the quality of human life. Efforts to improve pharmacy services in the main clinic need to be accompanied by an evaluation of the level of satisfaction. Consumer satisfaction is a response to every service received and is an important part because patient satisfaction cannot be separated from the quality of health services.            The purpose of this study was to determine the characteristics of patients based on gender, age, last education and occupation. Then to determine the level of patient satisfaction with pharmaceutical services.            The method used in this research is descriptive method with a quantitative approach. Data analysis uses percentages and a Likert scale. The population in this study were outpatients who received pharmacy services at the main clinical pharmacy installation "X" Semarang City.            The results of the characteristic study showed that 80% of the respondents were female. Based on the age of the respondents who visited the most were aged 26 - 35 years (33.1%), and the least were aged 56 - 65 years (7.4%). The majority of respondents have high school education (42.3%). Most of the respondents' occupational data in this study were other (60%), dominated by housewives. The frequency of visits (71.4%) of respondents visited more than 2 times and 28.6% of respondents visited 2 times. The average result of patient satisfaction based on five dimensions obtained a value of 3.04 with a satisfied statement. Keywords: Pharmaceutical services, ServQual, satisfaction, primary clinics
PENGARUH PEMBERIAN KONSELING GIZI TERHADAP PEMILIHAN MAKAN PADA REMAJA PUTRI OVERWEIGHT DAN OBESITAS
Authors: Maulidiyah Putri , Kurniasari Ratih
Published: May 2023

In Indonesia there are still many adolescents who experience multiple nutritional problems caused by the increasing number of population with more nutritional status, one of which is overweight. One of the causes of overweight is because of food selection. Food choices can be influenced by family eating habits, advertisements in various media, peers, and the environment. Nutrition counseling is a form of approach that aims to help clients/respondents identify and analyze problems with clients and provide alternative solutions to problems. The purpose of this study was to see the effect of providing nutritional counseling on food choices in overweight female adolescents. The method used in this research is literature review by collecting research journals or reviewing articles by searching the database using Google Scholar as many as 4 journals spanning 2017-2022. In this study, the provision of nutritional counseling can influence and change the choice of food for young women, who initially chose random food to choose good and healthy food. Keywords: nutrition counseling; overweight; youth;  food
Ability To Pay Dan Willingness To Pay Iuran BPJS Kesehatan Pada Pedagang Pasar Bulu Semarang Di Era Pandemi
Authors: Nurmandhani Ririn , Maharani Agnes Oktavi , Kusuma Agus Perry , Iqbal Muhammad
Published: May 2023

Market traders were included in the informal workers with the second largest proportion of 3.31 million people. The purpose of this study was to calculate the ability to pay and willingness to pay fur market traders for BPJS Health contributions during the pandemic. This type of research was descriptive through quantitative methods, there are 96 respondents to the fur market traders who were registered in the PBPU segment. Subjects were determined using Systematic Random Sampling. The results showed that most of the respondents' household income per month was classified as medium which was in the interval ? IDR 2.067.295,00 to ? IDR 5.168.237,00. The average total expenditure of household respondents was IDR 3.668.339,00. The biggest type of expenditure was non-food expenditure with an average total expenditure of IDR 1.756.523.00. The real amount of Ability To Pay (ATP) for Fur Market traders had an average value of IDR 84.792,00 per person per month. Most of the respondents (88.5%) were able to pay BPJS Health contributions. There were 11 respondents unable to pay BPJS Health contributions. Calculation of the estimated average Willingness To Pay (WTP) obtained was IDR 26.411.00. The researcher's suggestion is for BPJS Health to collaborate with the UPTD Semarang City market in the BPJS Health socialization program in order to increase the knowledge and awareness of traders about the importance of health insurance.
PERBEDAAN MENTAL HEALTH REMAJA PADA SMA NEGERI 3 DAN SMA MATARAM BERBASIS STRENGHT AND DIFFICULTIES QUESTIONNAIRE (SDQ) DI KOTA SEMARANG
Authors: Muthoharoh Nor Amalia , Setyawati Vilda Ana Veria , Aprianti Aprianti , Anggraini Fitria Dewi Puspita
Published: May 2023

The Covid-19 pandemic in recent years has been a global crisis and a non-natural disaster which has had a profound impact on all sectors of life, not only threatening people's physical health, but can also have an impact on mental and social health. Very significant changes like this can cause some negative responses such as fatigue, discomfort and anxiety.Adolescence is a period said to be a period of adolescent transition from childhood to adulthood. Many individuals who are in their teenage years will usually experience significant changes both physically, socially and psychologically in adolescence. Conditions like this are very disturbing mentally for adolescents, where adolescents feel uncomfortable, easily get emotional with their environment if it doesn't suit their wishes, the influence of geekjet also plays an important role in the emotional condition of adolescents. According to WHO lately the number of depression in adolescents shows that 80-90% of adolescents experience depression to the point of suicide, one of the causes of teenage depression is due to bullying, and emotions due to social media.This research focuses on early planning related to mental health in adolescents through initial screening using the SDQ as a movement effort to reduce the number of mental health disorders. Mental health is very important in supporting the productivity and quality of physical health in adolescents because where adolescence is a golden period in its development, it is expected that adolescents can manage stress and anxiety in themselves.Keywords: Mental, Health and Adolescent
Allelic Variants on SLC6A3 Neurotransmitter Gene and Their Relationship with Personality Traits Scales in Egyptian Athletes
Authors: EL-Seedy Ayman S. , Botros Mariam H. , Page Guylène , Ladeveze Veronique
Published: May 2023

Human dopamine transporter gene (SLC6A3) is one of the neurotransmission genes that plays an important role in controlling the behavior and psychological reactions toward various physical activities. The aim of the present study is to evaluate the associations between SLC6A3 3’-UTR VNTR (3’VNTR) genotypes and eight personality traits in Egyptian athletes. One hundred athletes (50 males and 50 females) and one hundred non-athletes participated in this investigation either in individual or team games. The Freiburg Personality inventory-Revised questionnaire was applied to athletes to evaluate personality traits according to the scale, at a scheduled time, using descriptive analysis. Genotyping for SLC6A3 3’-UTR VNTR polymorphism in athletes was realized to detect the different genotypes by PCR amplifications using desired primers. Three different genotypes of the 3’VNTR polymorphism; namely (9/9), (9/10), (10/10) were identified. The 9/10 and 10/10 genotypes of SLC6A3 gene were significantly higher in players than those in the control group. There were no statistically significant differences in personality traits values among males and females. The Cronbach’s alpha stability coefficient for four items is higher than 0.7 suggesting that these items (Neuroticism, Aggressiveness, Depression and Excitability) have a good reliability and support the used personality dimensions for this investigation. Our findings revealed a significant association between the genotypes of 3’VNTR and the personality traits in Egyptian athletes. These data shed light on the role of SLC6A3 gene in athletes’ behavioral performance and could serve as the basis for further characterization in the large number of Egyptian athletes.
Trade and the government underfunding of environmental innovation
Authors: Zhang Muzhou
Published: May 2023

How does trade affect the making and implementation of environmental policies? I extend our understanding about this broad research question with an understudied case: government support for environmental innovation. As the foremost channel wherein cross-border technology transfer occurs, trade materializes the positive externality of technology investment. With this in mind, countries may tend to strategically underfund environmental technologies—particularly when their trade partners enlarge that spending—to have more money to use other- wise and to avoid politically awkward innovation failures. To substantiate this crowding-out argument, I perform spatial regression with data from 32 OECD countries, 1982–2017, and find that government spending on environmental R&D in one country is negatively correlated with that of the country’s trade partners in environmental goods. Three contributions to the literature are identified and discussed.
Studi Literatur ; Terapi Emotional Freedom Technique (EFT) Terhadap Penurunan Ansietas Pasien Pre Operasi
Authors: Malaha Anniza Febriani , Suharto Dewi Nurviana , Nilasanti Ni Made Ridla , Manggasa Dafrosia Darmi
Published: May 2023

Tindakan pembedahan merupakan salah satu tindakan medis yang akan mendatangkan stresor terhadap integritas seseorang. Reaksi yang muncul berupa reaksi stres baik fisiologis maupun psikologis akan tetapi yang paling menonjol adalah reaksi secara psikologis berupa kecemasan. Salah  satu cara  mudah dan sederhana yang dapat dilakukan untuk mengurangi kecemasan adalah dengan memberikan terapi Emotional Freedom Technique (EFT). Tujuan : mengidentifikasi studi literature  yang  berhubungan  dengan Terapi Emotional Freedom Technique (EFT) Terhadap Penurunan Ansietas Pasien Dengan Pre Operasi Mayor. Metode  : basis data yang digunakan dalam studi literatur yaitu Publish Or Perish, Google Scholar, dan Google terbatas dari tahun 2015-2020. Hasil : ada 5 artikel yang digunakan dalam penelitian, dari kelima artikel didapatkan hasil bahwa Emotional Freedom Technique (EFT) memiliki pengaruh terhadap tingkat kecemasan pasien pre operasi. Kesimpulan : TerapiEmotional Freedom Technique (EFT)  mempunyai pengaruh yang signifikan terhadap penurunan tingkat kecemasan pasien pre operasi. Saran : Diharapkan hasil penelitian  ini bisa menambah pengetahuan dan wawasan peneliti selanjutnya tentang intervensi keperawatan yang dapat digunakan dalam kecemasan pada pasien pre operasi.
Literature Review : Aromaterapi Daun Mint Efektif Dalam Menurunkan Sesak Napas Pada Pasien TB Paru
Authors: Ichsan Moh , Caroline Lidya , Sunusi Misna , Irawati Lia
Published: May 2023

Pendahuluan: Penyakit infeksi yang paling sering menyerang system pernapasan adalah TB Paru. TB Paru terjadi karena infeksi bakteri Mycobacterium tuberculosis. Masalah yang paling sering muncul pada pasien dengan TB Paru adalah sesak napas. Salah satu intervensi keperawatan yang dapat diberikan pada pasien TB paru dengan masalah sesak napas yaitu dengan pemberian aromaterapi daun mint. Tujuan penelitian untuk mengidentifikasi dan menelaah lebih dalam literatur tentang efektifitas aromaterapi daun mint dalam menurunkan sesak napas. Metode: penelitian ini menggunakan literature review yaitu dengan pencarian literatur sistematis berbasis komputerisasi (Google Scholar) yang diambil dalam waktu 5 tahun terakhir, kata kunci yang digunakan yaitu “aromaterapi daun mint”, “TB Paru” dan “sesak napas”. Hasil: Hasil penelusuran sebanyak 5 artikel menunjukkan bahwa aromaterapi daun mint efektif dalam menurunkan sesak napas pada pasien TB Paru. Kesimpulan: aromaterapi daun mint efektif dalam menurunkan sesak napas pada pasien TB paru. Intervensi aromaterapi daun mint dapat dijadikan terapi pendamping pengobatan farmakologis pada pasien TB Paru dengan masalah keperawatan sesak napas.
Pengaruh Pemberian Jus Apel Hijau (Malus Sylvestris Mill) Terhadap Penurunan Kolesterol Darah Pada Penderita Hiperkolesterolemia
Authors: Achirman Achirman , Nur Afrida Ervina
Published: May 2023

Kolesterol terbentuk secara alami didalam tubuh yang merupakan dasar pe,bentuk hormon yang sangat diperlukan untuk mengatur pertumbuhan dan mekanisme kerja tubuh. Hiperkolesterolemia adalah keadaan dimana kadar kolesterol melebihi batas normal (>200 mg/dL), kondisi ini yang akan meningkatkan terjadinya penyakit jantung koroner dan stroke. Mengkonsumi buah dan sayur adalah salah satu terapi Nonfarmakologis untuk menjaga kolesterol. Buah apel yang memiliki banyak kandungan yang bermanfaat bagi tubuh, salah satunya adalah quercetin yang berperan sebagai antioksidan untuk melawan kolesterol jahat (LDL). Peneltian menggunakan metode penelitian Qusay Experiment dengan rancangan One Group Pretest Posttest, dimana eksperimen ini hanya menggunakan 1 kelompok perlakuan dengan sampel sebanyak 18 orang dengan kriteria inklusi dan ekslusi. Alat ukur yang digunakan adalah test kolesterol Easy Touch GCU, data diuji dengan T-test. Nilai rata-rata Pretest sebesar 228,28 mg/dL , dan rata-rata nilai Posttest sebesar 195,67 mg/dL Hasil uji T-test p value=0,000 yang menunjukan bahwa ada pengaruh yang signifikan terhadap penurunan kadar kolesterol darah seterlah diberikan jus apel hijau. Terdapat pengaruh pemberian jus apel hijau (Malus Sylvetreis Mill) terhadap penurunan kadar kolesterol darah pada penderita hiperkolesterolemia.
Saberes docentes evidenciados em atividade desenvolvida no contexto de um ambiente virtual
Authors: Koga Mariane Alves , Silva Karina Alessandra Pessoa da , Rocha Zenaide de Fátima Dante Correia
Published: May 2023

Este artigo busca apresentar reflexões de uma pesquisa que evidenciou saberes docentes em uma atividade desenvolvida em um ambiente virtual de ensino e aprendizagem de uma disciplina de Modelagem Matemática na perspectiva do ensino. O ambiente virtual, entendido como espaço de troca de informações e reflexões, subsidiou o desenvolvimento da atividade de modelagem por um grupo de estudantes de pós-graduação em ensino de matemática em formação continuada. As falas e registros compartilhados pelos estudantes em formação subsidiaram uma pesquisa qualitativa de cunho interpretativo de uma atividade experimental desenvolvida em momentos sí­ncronos e assí­ncronos. A transcrição das falas possibilitou inferir saberes profissionais, saberes disciplinares e saberes experienciais que emergiram da troca de ideias entre os estudantes.
Retomando algumas reflexões de Maturana sobre a educação
Authors: Manzi Ronaldo Filho
Published: May 2023

Esse artigo busca realizar uma discussão entre as teorias neoliberais sobre a educação com as reflexões que Maturana nos traz a partir da biologia. Maturana nos surpreende ao discutir questões que aparentemente estão fora do domí­nio da biologia, tais como a ética, a polí­tica, a cultura e a educação. Ao que nos levaria pensar a educação a partir de premissas biológicas? Como seria possí­vel se contrapor ao que foi naturalizado em nossa cultura, como a questão da concorrência, a partir de uma ideia biológica? Afinal, seria possí­vel um discurso da biologia da educação? Teria algum fundamento esse tipo de discurso? Qual seria? E se partí­ssemos de uma ideia de que é o amor que fundamenta o social? Sua argumentação é contraintuitiva: o amor é o fundamento do social, mas nem toda convivência é social. Partiremos de duas palestras desse pensador que foram traduzidas no Brasil como Emoções e linguagem na educação e na polí­tica. Maturana insiste nessas palestras que há um fundamento emocional do social. De forma contraintuitiva, seria o amor que fundamentaria o social – o que tornaria possí­vel a aceitação do outro na convivência mútua. Quais as consequências dessa teoria para a educação?
"Obstáculos Filosóficos" na Ética do Ensino das Ciências e dos Estudos do Imaginário em Bachelard
Authors: Da Rocha Gabriel Kafure , Silva Nilton Guimarães
Published: May 2023

O presente trabalho tem como objetivo demonstrar a importância da atualidade do pensamento bachelardiano no Brasil no processo de ensino e aprendizagem por meio do estudo na í­ntegra de sua obra na lí­ngua francesa e do resgate de textos ainda não traduzidos. Relatamos assim a experiência de um grupo de estudos sobre essa filosofia, que surgiu a partir da ideia de aprender francês por meio da filosofia, e desse desdobramento, começar a traduzir pequenos textos de modo a trazer para o público acadêmico novas referências crí­ticas para estudos aprofundados sobre Gaston Bachelard após 60 anos de sua morte. Assim, é possí­vel enfatizar o caráter aberto da filosofia da imaginação bachelardiana por meio da linguagem do filósofo na transcrição de palestras radiofônicas chamadas de Causeries, tanto as publicadas como outras que ainda estavam em formato de áudio. Indo além desse objeto, podemos caracterizar na própria filosofia bachelardiana os problemas dos obstáculos epistemológicos, filosóficos e pedagógicos que perpassaram nossa própria experiência conceitual e de como tal processo gerou uma superação transformada em publicações de artigos que dialogam num pluralismo coerente acerca da filosofia bachelardiana na transição da graduação para a pós-graduação.
Um estudo dos invariantes operatórios mobilizados por estudantes da terceira série do Ensino Médio sobre o efeito fotoelétrico
Authors: Carvalho Bianca Cintra de , Gomes Luciano Carvalhais
Published: May 2023

Este trabalho tem por objetivo apresentar os invariantes operatórios mobilizados por alunos da terceira série do Ensino Médio sobre o efeito fotoelétrico em situações didáticas. A aplicação desse estudo ocorreu em um colégio particular da cidade de Nova Esperança – Paraná, no ano de 2019. Como sujeitos da pesquisa, participaram quarenta e três alunos da terceira série do Ensino Médio. Com base em nossos objetivos de pesquisa, para a constituição dos dados, realizamos uma observação participante e, como instrumento de coleta de dados, utilizamos questionários. Para este artigo, selecionamos três questões, aplicadas ao longo de uma atividade didática, nas quais abordamos sobre o efeito fotoelétrico. Inicialmente, discutimos o processo de eletrização de um eletroscópio e as possí­veis formas de descarregá-lo. Na sequência, apresentamos novamente o experimento e pedimos para que testassem descarregar com uma fonte de luz (lanterna do celular e Luzes de LED coloridas). Após esse momento, promovemos uma discussão acerca dos conceitos que envolvem o efeito fotoelétrico. Em nossa análise, a maioria dos invariantes operatórios mobilizados no primeiro momento, antes da realização do experimento, consideravam que a luz, por não ser partí­cula e sim uma onda, não seria capaz de interagir com os elétrons e descarregar o eletroscópio. Ao serem questionados novamente, após testarem experimentalmente a luz descarregando o eletroscópio, percebe-se uma diversidade de conceitos e teoremas-em-ação mobilizados, os quais buscam em seus esquemas já existentes, encaixar o que foi observado. Por fim, na análise da terceira atividade didática, após a investigação experimental e conceitual do efeito fotoelétrico, percebe-se a mobilização de invariantes operatórios mais próximos do conhecimento cientí­fico. Sem a pretensão de esgotar o assunto, esperamos que os resultados encontrados contribuam para uma melhor compreensão dos invariantes operatórios sobre efeito fotoelétrico e subsidiem caminhos para abordar a Fí­sica Moderna, em especial a Fí­sica Quântica, no Ensino Médio.
Constraining the Geochemical Fingerprints of Gases from the UK Carboniferous Coal Measures at the Glasgow Geoenergy Observatories Field Site, Scotland
Authors: Chambers Rebecca M. , Johnson Gareth , Boyce Adrian J. , Gilfillan Stuart M. V.
Published: May 2023

Usage of thermal energy contained in abandoned, flooded, coal mines has the potential to contribute to low carbon heating or cooling supply and assist in meeting net-zero carbon emission targets. However, hazardous ground gases, such as CH
4
and CO
2
, can be found naturally in superficial deposits, coal bearing strata and abandoned mines. Determining the presence, magnitude, and origin of subsurface gases, and how their geochemical fingerprints evolve within the shallow subsurface is vital to developing an understanding of how to manage the risk posed by ground gases in geoenergy technology development. Here, we present the first CH
4
and CO
2
concentration-depth profiles and stable isotope (δ
13
C
CH4
, δ
13
C
CO2
, and δD
CH4
) profiles obtained from UK mine workings, through analysis of headspace gas samples degassed from cores and chippings collected during construction of the Glasgow Observatory. These are used to investigate the variability of gas fingerprints with depth within unmined Carboniferous coal measures and Glasgow coal mine workings. Stable isotope compositions of CH
4
(δ
13
C
CH4
= −73.4‰ to −14.3‰; δ
13
C
CO2
= −29‰ to −6.1‰; δD
CH4
= −277‰ to −88‰) provide evidence of a biogenic source, with carbonate reduction being the primary pathway of CH
4
production. Gas samples collected at depths of 63–79 m exhibit enrichments in 13C
CH4
and
2
H, indicating the oxidative consumption of CH
4
. This correlates with their proximity to the Glasgow Ell mine workings, which will have increased exposure to O
2
from the atmosphere as a result of mining activities. CO
2
gas is more abundant than CH
4
throughout the succession in all three boreholes, exhibiting high δ
13
C
CO2
values relative to the CH
4
present. Gases from unmined bedrock exhibit the highest δ
13
C
CO2
values, with samples from near-surface superficial deposits having the lowest δ
13
C
CO2
values. δ
13
C
CO2
values become progressively lower at shallower depths (above 90 m), which can be explained by the increasing influence of shallow groundwaters containing a mixture of dissolved marine carbonate minerals (∼0‰) and soil gas CO
2
(−26‰) as depth decreases. Our findings provide an insight into the variability of mine derived gases within 200 m of the surface, providing an important ‘time-zero’ record of the site, which is required in the design of monitoring approaches.
Establishing and characterizing human stem cells from the apical papilla immortalized by hTERT gene transfer
Authors: Cheng Qianyu , Liu Chang , Chen Qiuman , Luo Wenping , He Tong-Chuan , Yang Deqin
Published: May 2023

Stem cells from the apical papilla (SCAPs) are promising candidates for regenerative endodontic treatment and tissue regeneration in general. However, harvesting enough cells from the limited apical papilla tissue is difficult, and the cells lose their primary phenotype over many passages. To get over these challenges, we immortalized human SCAPs with lentiviruses overexpressing human telomerase reverse transcriptase (hTERT). Human immortalized SCAPs (hiSCAPs) exhibited long-term proliferative activity without tumorigenic potential. Cells also expressed mesenchymal and progenitor biomarkers and exhibited multiple differentiation potentials. Interestingly, hiSCAPs gained a stronger potential for osteogenic differentiation than the primary cells. To further investigate whether hiSCAPs could become prospective seed cells in bone tissue engineering, in vitro and in vivo studies were performed, and the results indicated that hiSCAPs exhibited strong osteogenic differentiation ability after infection with recombinant adenoviruses expressing BMP9 (AdBMP9). In addition, we revealed that BMP9 could upregulate ALK1 and BMPRII, leading to an increase in phosphorylated Smad1 to induce the osteogenic differentiation of hiSCAPs. These results support the application of hiSCAPs in tissue engineering/regeneration schemes as a stable stem cell source for osteogenic differentiation and biomineralization, which could be further used in stem cell-based clinical therapies.
Bioinformatics analysis of aging-related genes in thoracic aortic aneurysm and dissection
Authors: Wan Hong , Liu Danlingyi , Liu Bingqing , Sha Mengyao , Xia Wei , Liu Chang
Published: May 2023

Objective

Thoracic aortic aneurysm and dissection (TAAD) is a cardiovascular disease with a high mortality rate. Aging is an important risk factor for TAAD. This study explored the relationship between aging and TAAD and investigated the underlying mechanisms, which may contribute to the diagnosis and treatment of TAAD.

Methods

Human aging genes were obtained from the Aging Atlas official website. Various datasets were downloaded from the GEO database:the human TAAD dataset GSE52093 were used for screening differentially expressed genes (DEGs); GSE137869, GSE102397 and GSE153434 were used as validation sets, and GSE9106 was used for diagnostic prediction of receiver operating characteristic (ROC) curves. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Set Enrichment Analysis (GSEA), and protein–protein interaction (PPI) network analysis were used to screen differentially co-expressed genes from human aging genes and TAAD. Using five methods of the cytoHubba plugin in Cytoscape software (Degree, Closeness, EPC, MNC, Radiality), hub genes were identified from the differentially co-expressed genes. Single-cell RNA sequencing was used to verify the expression levels of hubgenes in different cell types of aortic tissue. ROC curves were used to further screen for diagnostic genes.

Results

A total of 70 differentially co-expressed genes were screened from human aging genes and DEGs in human TAAD dataset GSE52093. GO enrichment analysis revealed that the DEGs played a major role in regulating DNA metabolism and damaged DNA binding. KEGG enrichment analysis revealed enrichment in the longevity regulating pathway, cellular senescence, and HIF-1 signaling pathway. GSEA indicated that the DEGs were concentrated in the cell cycle and aging-related p53 signaling pathway. The five identified hubgenes were MYC, IL6, HIF1A, ESR1, and PTGS2. Single-cell sequencing of the aging rat aorta showed that hubgenes were expressed differently in different types of cells in aortic tissue. Among these five hubgenes, HIF1A and PTGS2 were validated in the aging dataset GSE102397; MYC, HIF1A and ESR1 were validated in the TAAD dataset GSE153434. The combined area under the diagnostic ROC curve (AUC) values for the five hub genes were >0.7 in the testing and training sets of the dataset GSE9106. The combined AUC values of MYC and ESR1 were equal to the combin ed AUC values of the five hub genes.

Conclusion

The HIF-1 signaling pathway may play an important role in TAAD and aging. MYC and ESR1 may have diagnostic value for aging-related TAAD.
Using Mendelian randomization analysis to determine the causal connection between unpleasant emotions and coronary atherosclerosis
Authors: Lei Jiyong , Luo Da , Xiong Jiarui , Li Mingjiang
Published: May 2023

Objective

Observational studies have shown a correlation between unpleasant emotions and coronary atherosclerosis, but the underlying causal linkages are still uncertain. We conducted a Mendelian randomization (MR) investigation on two samples for this purpose.

Methods

In genome-wide association studies in the UK Biobank (total = 459,561), we selected 40 distinct single-nucleotide polymorphisms (SNPs) related to unpleasant emotions as genome-wide statistically significant instrumental variables. FinnGen consortium provided summary-level data on coronary atherosclerosis for 211,203 individuals of Finnish descent. MR-Egger regression, the inverse variance weighted technique (IVW), and the weighted median method were used in the process of conducting data analysis.

Results

There was sufficient evidence to establish a causal connection between unpleasant emotions and coronary atherosclerosis risk. For each unit increase in the log-odds ratio of unpleasant feelings, the odds ratios were 3.61 (95% CI: 1.64–7.95; P = 0.001). The outcomes of sensitivity analyses were comparable. There was no indication of heterogeneity or directional pleiotropy.

Conclusion

Our findings provide causal evidence for the effects of unpleasant emotions on coronary atherosclerosis.
A CT-FFR-guided unroofing procedure for repairing the anomalous origin of the left coronary artery—a case report
Authors: Zuo Hairun , Xu Chengyi , Wang Li , Liu Chengwei , Liu Li , Su Xi
Published: May 2023

Anomalous aortic origin of a coronary artery (AAOCA) is a congenital malformation of the coronary arteries that includes several subtypes. It is a leading cause of sudden cardiac death in young people, especially in competitive athletes. An accurate diagnosis and identification of high-risk patients with AAOCA for referral for surgical repair can help in the management of these patients. However, current diagnostic tools such as invasive angiography, echocardiography, and intravascular ultrasound have known limitations in visualizing coronary orifices and characterizing vessels. In this case report, we report on a 14-year-old adolescent who suffered from repeated incidents of syncope during exercise. Using the computed tomographic fractional flow reserve (CT-FFR) technique, we diagnosed AAOCA, which revealed that his left coronary artery (LCA) originated from the right sinus of Valsalva and ran between the aorta and the pulmonary artery with an intra-arterial wall course (∼20 mm in length), with an abnormal FFR of the LCA at rest. The patient was referred for undergoing unroofing surgery, and the results of repeat CT-FFR showed a significantly improved FFR of the LCA. The patient resumed his normal physical activities without the recurrence of syncope. In this report, we highlight the usefulness of CT-FFR as a non-invasive, feasible, and effective tool to guide whether a patient with AAOCA requires surgical revascularization and to evaluate the effectiveness of the procedure after surgery.
The feasibility and safety of his-purkinje conduction system pacing in patients with heart failure with severely reduced ejection fraction
Authors: Ma Chengming , Wang Zhongzhen , Ma Zhulin , Ma Peipei , Dai Shiyu , Wang Nan , Yang Yiheng , Li Guocao , Gao Lianjun , Xia Yunlong , Xiao Xianjie , Dong Yingxue
Published: May 2023

Objective

The purpose of this study was to evaluate the feasibility and outcomes of conduction system pacing (CSP) in patients with heart failure (HF) who had a severely reduced left ventricular ejection fraction (LVEF) of less than 30% (HFsrEF).

Methods

Between January 2018 and December 2020, all consecutive HF patients with LVEF < 30% who underwent CSP at our center were evaluated. Clinical outcomes and echocardiographic data [LVEF and left ventricular end-systolic volume (LVESV)], and complications were all recorded. In addition, clinical and echocardiographic (≥5% improvement in LVEF or ≥15% decrease in LVESV) responses were assessed. The patients were classified into a complete left bundle branch block (CLBBB) morphology group and a non-CLBBB morphology group according to the baseline QRS configuration.

Results

Seventy patients (66 ± 8.84 years; 55.7% male) with a mean LVEF of 23.2 ± 3.23%, LVEDd of 67.33 ± 7.47 mm and LVESV of 212.08 ± 39.74 ml were included. QRS configuration at baseline was CLBBB in 67.1% (47/70) of patients and non-CLBBB in 32.9%. At implantation, the CSP threshold was 0.6 ± 0.3 V @ 0.4 ms and remained stable during a mean follow-up of 23.43 ± 11.44 months. CSP resulted in significant LVEF improvement from 23.2 ± 3.23% to 34.93 ± 10.34% (P < 0.001) and significant QRS narrowing from 154.99 ± 34.42 to 130.81 ± 25.18 ms (P < 0.001). Clinical and echocardiographic responses were observed in 91.4% (64/70) and 77.1% (54/70) of patients. Super-response to CSP (≥15% improvement in LVEF or ≥30% decrease in LVESV) was observed in 52.9% (37/70) of patients. One patient died due to acute HF and following severe metabolic disorders. Baseline BNP (odds ratio: 0.969; 95% confidence interval: 0.939–0.989; P = 0.045) was associated with echocardiographic response. The proportions of clinical and echocardiographic responses in the CLBBB group were higher than those in the non-CLBBB group but without significant statistical differences.

Conclusions

CSP is feasible and safe in patients with HFsrEF. CSP is associated with a significant improvement in clinical and echocardiographic outcomes, even for patients with non-CLBBB widened QRS.
Characteristics of out-of-hospital cardiac arrest patients in Riyadh province, Saudi Arabia: a cross-sectional study
Authors: Almiro Alyaman , AlQassab Osamah , Alzeidan Rasmieh , Binhaddab Abdulaziz Saad , Alkhorisi Ahmad M. , Almalki Hani A , Ghouthalsayd Muhannad Abdulaziz , Kashour Tarek , Hersi Ahmed , Alqarawi Wael
Published: May 2023

Introduction

Little work has been done on out-of-hospital cardiac arrest (OHCA) in Saudi Arabia. Our goal is to report the characteristics of OHCA patients and predictors of bystander cardiopulmonary resuscitation (CPR).

Materials and methods

This cross-sectional study utilized data from the Saudi Red Crescent Authority (SRCA), a governmental emergency medical service (EMS). A standardized data collection form based on the “Utstein-style” guidelines was developed. Data were retrieved from the electronic patient care reports that SRCA providers fill out for every case. OHCA cases that were attended by SRCA in Riyadh province between June 1st, 2020 and May 31st, 2021 were included. Multivariate regression analysis was performed to assess independent predictors of bystander CPR.

Results

A total of 1,023 OHCA cases were included. The mean age was 57.2 (±22.6). 95.7% (979/1,023) of cases were adults and 65.2% (667/1,023) were males. Home was the most common location of OHCA [784/1,011 (77.5%)]. The initial recorded rhythm was shockable in 131/742 (17.7%). The EMS mean response time was 15.9 min (±11.1). Bystander CPR was performed in 130/1,023 (12.7%) and was more commonly performed in children as compared to adults [12/44 (27.3%) vs. 118/979 (12.1%), p = 0.003]. Independent predictors of bystander CPR were being a child (OR = 3.26, 95% CI [1.21–8.82], p = 0.02) and having OHCA in a healthcare institution (OR = 6.35, 95% CI [2.15–18.72], p = 0.001).

Conclusion

Our study reported the characteristics of OHCA cases in Saudi Arabia using EMS data. We observed young age at presentation, low rates of bystander CPR, and long response time. These characteristics are distinctly different from other countries and call for urgent attention to OHCA care in Saudi Arabia. Lastly, being a child and having OHCA in a healthcare institution were found to be independent predictors of bystander CPR.