bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect Of Self-Care Program On Hypertension Patients In The Islands
Authors: Sukarna R Ade , Abilowo Ashar
Published: January 2025

Hypertension is the leading cause of death from cardiovascular disease. Approximately 75% of the world's hypertensive population lives in low- and middle-income countries (LMICs). The results of the Basic Health Survey in Indonesia in 2018 show that the prevalence of hypertension has increased compared to 2013. The increase in patients with hypertension as a chronic disease requires independent self-care and routine monthly visits to health services. This study aims to determine the effect of self-management programs on blood pressure in hypertensive patients in the islands. The study was conducted in Belitung Island, Indonesia. The design of this study was quasi-experimental with pre-post test with control group. The sample was taken by convenience sampling technique with a total of 100 participants divided into 50 control groups and 50 intervention groups. Data were collected using self-care modules, questionnaire sheets, and blood pressure measured with a digital sphygmomanometer. Paired t-test and independent t-test were used for data analysis. Results of the study were collected at weeks 4 and 8. After 8 weeks of self-care with the provided modules, the results showed a significant relationship between mean blood pressure before and after the intervention
Effectiveness of Sexuality education program in reducing the risk of teenage pregnancy
Authors: Qoyyimah Anna Uswatun , Kristiana Yenni , Rahayu Tri Budi , Aldo Novian
Published: January 2025

This study aims to assess the effectiveness of sexuality education programs in reducing the risk of teenage pregnancy. Using a quantitative survey method, data were collected from 220 adolescent respondents to evaluate their knowledge, attitudes, and behaviors related to sexual health before and after participating in the program. The survey focused on key aspects such as knowledge of reproductive health, sexual behavior, and contraceptive use. Statistical analysis was conducted to determine if there were significant changes in participants' attitudes and behaviors following the intervention. The findings of this research are expected to provide valuable insights into the impact of sexuality education on teenage pregnancy rates and offer recommendations for improving the design and implementation of such programs.
The Role of Midwives in Postpartum Health Monitoring to Reduce the Risk of Postpartum Complications
Authors: Qiftiyah Mariyatul , Ulfa Siti Maria , Hastuti Puji , Octamelia Mega
Published: January 2025

This research aims to explore the role of midwives in postpartum health monitoring and its impact on reducing the risk of postpartum complications. Postpartum complications, such as infections, bleeding, and mental health disorders, remain significant health challenges for mothers following childbirth. The study utilizes a quantitative survey method to measure the relationship between midwifery interventions and the occurrence of these complications. Data were collected from 260 postpartum mothers who received care from midwives, with a focus on the frequency of visits, types of services provided, and health outcomes. The findings suggest that regular postpartum monitoring by midwives significantly reduces the risk of complications, highlighting the importance of early detection, education, and ongoing support. This research contributes to understanding the effectiveness of midwifery care and provides recommendations for improving healthcare policies related to maternal health.
Analysis of Visibility and Accessibility of the International Test Center (ITC) as a Foreign Language Test Center at Manado State Polytechnic
Authors: Lagarens Yollanda , Tombeg Beldie A. , Kaligis Stevie , Samehe Valen
Published: January 2025

In the era of Education 5.0, education focuses on holistic human development by utilizing technology to create personalized and adaptive learning experiences and prepare students to face global challenges. Foreign language skills are becoming increasingly important as core competencies that support international mobility and cross-cultural collaboration. Foreign language tests serve as an evaluation tool to measure individual language skills, ensuring graduates can compete in the global market. This study aims to analyze the visibility and accessibility of the International Test Center (ITC) as a foreign language test center at the Manado State Polytechnic. The main focus of the study includes an evaluation of geographical distribution, transportation infrastructure, facilities provided, and test takers' perceptions of the ease and efficiency of services. The research method used is qualitative, including location surveys, interviews, participant observation, and document analysis. Qualitative data were obtained through interviews with institutional leaders, test implementers, partners, participants, and direct observation at the language center location. The study results indicate that the International Test Center has great potential to become one of the best foreign language test centers in North Sulawesi. However, there are still challenges regarding transportation accessibility and participant perceptions of service efficiency. The implications of this research are expected to be the basis for further development for ITC to increase the visibility, accessibility, and quality of its services as a center of excellence for foreign language testing at Manado State Polytechnic.
Barriers and Opportunities: The Influence of Social and Cultural Dynamics on Girls' Secondary Education in Tribal Regions of Khyber Pakhtunkhwa, Pakistan
Authors: Ullah Kefayat
Published: January 2025

Girls' education is one of the persistent dilemmas facing mostly tribal regions of developing countries, including Pakistan. This study explores the complex social and cultural factors that influence girls' secondary education in the tribal regions of Khyber Pakhtunkhwa, Pakistan, specifically focusing on the district Bajaur. The study aims to explore the barriers and opportunities surrounding post-primary girls' education. In this qualitative study, eighteen (18) male guardians of the girls were recruited for in-depth interviews using an interview guide through a purposive sampling technique. Thematic analysis technique was utilized to analyze the data while engaging "equity of opportunity in education" discourse as a theoretical framework to examine the socio-cultural dynamics of the region. The findings illustrate that most of the participants support both boys' and girls' secondary education, and many perceive the cultural environment as conducive to girls' secondary education. However, the study also reveals multifaceted challenges faced by young girls, including governmental neglect, illiterate parents, and the unavailability of educational facilities. These are the key barriers that discourage girls from pursuing post-primary schooling. The study offers key policy recommendations and highlights its theoretical and practical contributions to tackling the educational disparities faced by girls in tribal areas.
Desarrollo de un modelo de aprendizaje colaborativo para la enseñanza de la historia en Ecuador
Authors: Moreira-Alcivar Elvin Fray
Published: January 2025

The article develops a collaborative learning model to improve the teaching of history in Ecuador, overcoming the limitations of traditional methodologies that demotivate students and limit their critical thinking. Based on a literature review, the model proposes structured collaborative activities that promote teamwork and reflective analysis, along with the integration of educational technologies, such as digital platforms and multimedia resources. The projected results include increased student motivation, development of critical competencies and strengthening of teacher training. This approach seeks to transform the educational dynamic, making it more inclusive and relevant to contemporary demands. However, its success requires overcoming barriers such as unequal access to technological resources and the need for ongoing teacher training. The model not only fosters a deeper understanding of historical processes, but also contributes to the integral development of students and the strengthening of the educational system in the country.
Incidencia de la crisis energética en los costos de producción en empresas manufactureras
Authors: Alvarez-Villagómez Jenniffer Verónica , Concha-Ramírez Jhonny Antonio
Published: January 2025

The study analyzes the impact of the energy crisis on the production costs of manufacturing companies in Ecuador, a country with a high dependence on oil and limited diversification of its energy matrix. Using a mixed approach, financial projections were made based on statistical data from INEGI, the Central Bank of Ecuador and corporate income statements for the periods 2023-2024, complemented by a qualitative analysis that included case studies, reports and internal communications. The results show that energy instability has increased operating costs, affecting productivity due to interruptions, wasted raw materials, and damaged machinery. Although strategies such as the adoption of efficient technologies, diversification towards renewable energies and reorganization of production schedules have partially mitigated these effects, economic losses persist due to the lack of structural planning and effective public policies. The discussion highlighted the need to modernize energy infrastructure and establish incentives for sustainable technologies, as well as comprehensive policies that promote a diversified and efficient energy matrix. It is concluded that a comprehensive approach combining energy efficiency, advanced cost management and government support is key to reducing the vulnerability of the manufacturing sector and ensuring its long-term competitiveness.
Generalized Hamiltonian Transformations
Authors: Mansur Abdallah
Published: January 2025

In this article, we discuss the G-Hamiltonian system which is a generalization of the traditional Hamiltonian system in mechanics. Moreover, we demonstrate that when given a G-Hamiltonian system of differential equations, such as dx/dt=Ax, the transformations that have this form dy/dt=BA^{-1}By are also G-Hamiltonian. Furthermore, we discuss the G-Lagrangian structure which is a generalization of the traditional Lagrangian formulation in mechanics.
On the Exponential Diophantine Equation 29^x+28^y=z^2
Authors: Gayo William
Published: January 2025

We first show the condition for which the Diophantine equation w^x+(w-1)^y=z^2, where w is a positive integer of the form 24N+5, may admit nonnegative integer solutions. Then, using this condition and the modular arithmetic method, we demonstrate that the Diophantine equation 29^x+28^y=z^2 has no solution in nonnegative integers.
La revolución digital en el sector turístico. Oportunidad para el turismo en España
Authors:   Universidad de Alicante, Más Ferrando Adrián , Ramón Rodríguez Ana B. ,   Universidad de Alicante, Aranda Cuéllar Patricia ,   Universidad de Alcalá
Published: January 2025

La industria turística más tradicional está experimentando una penúltima revolución industrial que requiere no solo de un proceso de adaptación continua por parte de los agentes implicados, sino también de un análisis de sus consecuencias. El sector turístico en España supone un pilar fundamental en su economía y empleo, sin embargo, nos encontramos ante un sector que no crea su propia innovación, haciendo que la especialización turística española sea vulnerable y dependiente. Este trabajo tiene por objetivo analizar el estado actual del turismo español y el reto tecnológico al que se enfrentan sus ventajas comparativas cuando se ven amenazadas por los nuevos competidores disruptivos que basan su modelo de negocio en las nuevas tecnologías de inteligencia artificial y en la economía de plataforma, siendo estos agentes disruptivos los que tienen la capacidad de cambiar la oferta y la demanda del sector.
Analysis the Effect of Control Valve Opening on Loading Crude Glycerine Water Pump Motor At PT. Unilever Oleochemical Indonesia
Authors: Brid Dwiki Darma Nuriono , Tharo Zuraidah , Wibowo Pristisal
Published: January 2025

In the palm oil industry, three-phase induction motors have a very important role in the production process. One of the problems that arises is the quality of the loading power on the motor which can make the motor performance less than optimal. In this study, an analysis and calculation of the power of a three-phase induction motor were carried out with the condition of opening the control valve in stages from 0% to 100%. The motor to be discussed is a three-phase induction motor that works as a pump driver for transferring crude glycerine water to the tank farm at the fatty acid 2 plant at PT. Unilever Oleochemical Indonesia. By using the observation method in conducting research to obtain measurement data, the variables taken are changes in current, power factor, and input power. From the results of this study, the output power value and power efficiency on the motor were obtained when the valve was opened 0%-100%, at the highest valve opening      of 100%, the motor output power was 4.39 KW with a power efficiency on the motor of 95%, at the lowest valve opening, the motor output power was 3.22 KW with an efficiency value obtained 95%.
Pemberdayaan Masyarakat Melalui Program KKN: Studi Kasus Di Dusun Sukaraja 3
Authors: Nurhikmah Sri , Rahmawati Baiq Maura Sri , Purnamasari Serli , Siti Khadijah Noviana  , Inda Sari Suci Nur , Wiranti Ria , Handayani Putri , Hidayat Hiranda , Husen  , Mustiadi  , Amrul Ahmad , Fadli Saiful
Published: January 2025

Kuliah Kerja Nyata (KKN) merupakan salah satu program pengabdian masyarakat yang dilaksanakan oleh mahasiswa untuk memberikan kontribusi dalam pengembangan sosial, pendidikan, dan infrastruktur di suatu daerah. Program KKN yang dilaksanakan di Dusun Sukaraja 3 bertujuan untuk meningkatkan kualitas hidup masyarakat melalui berbagai kegiatan yang mencakup pendidikan, kebersihan lingkungan, pembangunan infrastruktur, dan kegiatan sosial keagamaan. Artikel ini mengkaji pelaksanaan KKN yang dilakukan oleh mahasiswa Universitas Qamarul Huda Badaruddin Bagu di Dusun Sukaraja 3, dengan fokus pada program-program yang dilaksanakan, dampak yang ditimbulkan, serta kontribusi mahasiswa terhadap masyarakat setempat. Hasil dari pelaksanaan KKN ini menunjukkan bahwa program yang dijalankan berhasil menciptakan hubungan yang harmonis antara mahasiswa dan masyarakat, sekaligus memberikan manfaat langsung dalam aspek pendidikan dan pembangunan infrastruktur yang berkelanjutan.
Service Quality and Facilities on Satisfcation Through Individual Emotional for Bpjs Participants in Sinjai District
Authors: Nurlaela Nurlaela , Syarifuddin Umar , Liong Harlina , Munawwarah Rofiqah Al
Published: January 2025

This research aims to analyze product innovation and marketing strategies implemented by Bundang's Sweet and Sour Candy MSMEs to increase competitiveness in the market. The research method used is descriptive qualitative with data collection through interviews, observation and documentation studies. The research results show that product innovation, such as the development of more attractive flavor variants and packaging, contributes significantly to increasing consumer interest. On the other hand, digital-based marketing strategies through social media and marketplaces have also succeeded in expanding market reach. With a combination of product innovation and effective marketing, these MSMEs are able to compete with similar products and increase market share. This research recommends strengthening the synergy between product innovation and marketing as the key to success in facing increasingly fierce competition
Employee empowerment and employee attitudes towards work in government-aided secondary schools in Nakawa Division
Authors:   ,   Uganda Martyrs University, Kwikiriza Zoe
Published: January 2025

The study examined the influence of employee empowerment on employee attitudes among government aided secondary schools in Nakawa Division. It was guided by three research objectives which were; To examine the influence of employee competence, employee autonomy on employee attitudes in government aided secondary schools in Nakawa Division and the relationship between employee effectiveness and employee attitudes. The study used a cross sectional survey design with both qualitative and quantitative results. The study population involved teachers, head teachers and their deputies, bursars and administrators. Data was collected using questionnaires and interviews. In data analysis, Means and Standard Deviations, correlations and regressions were used to show the magnitude of the effect the independent variables have on the dependent variable. The study findings revealed that employee competence had a positive significant relationship to employee attitudes (r=.635, p=.000) with coefficient of determination R2=0.404 which shows that 40.4% variation in employee attitudes is explained by changes in employee competence. Findings also revealed that employee autonomy significantly affects employee attitudes (r=.486, p=.000) with a coefficient of determination R2 of .236 that indicates 23.6% chance change in employee attitudes is explained by employee attitudes. Also it was found out that there is a positive significant relationship between employee effectiveness and employee attitudes (r=.767, p=.000) with a regression coefficient determination of .588 meaning that 58.8% chance change in employee attitudes is explained by changes in employee effectiveness. It was therefore concluded that: There is generally less employee empowerment in government aided schools. Government aided school. Themselves have endeavored to put in place ways of how to empower the competencies of employees at different levels in their schools. However this is not sufficient enough to enable them to fully deploy their effectiveness at work. Most employees do not feel their self worthiness as a result of working in these schools. It was therefore recommended that there is need to revitalize the different sources of income like PTA in these schools, involve all departments in training and skills development and emphasize aspects like delegation and rotation of different roles in these schools.
Konseling Individual dalam Mengatasi Peserta Didik yang Mengalami Homesick di MAN Insan Cendekia Tanah Laut
Authors: Humairah Dalila  , Haris Fadillah
Published: January 2025

This research aims to determine the implementation of individual counseling in dealing with students who experience homesickness at MAN Insan Cendekia Tanah Laut. This research uses a type of field research. with a qualitative descriptive approach. Data collection techniques were carried out through interviews with students and guidance and counseling teachers, observation and documentation as supporting facilitation. The data analysis technique used is engineering qualitative descriptive analysis. As well as validating the data using triangulation techniques data to strengthen the validity of the data. From the research results, it was found that in an effort to overcome the problem of homesickness, the guidance and counseling teachers provided assistance through individual counseling. Individual counseling is provided through 4 activity stages, namely planning, activities planning starting from identifying students to creating RPL includes appointment time and place of meeting. Implementation is divided into three stages starting from building good relationships, exploring problems, and arriving at ensure students make changes in a positive direction. Evaluation, with a decrease in anxiety in students and follow-up activities, carry out follow-up activities on student development in collaboration with dormitory supervisors, homeroom teachers, foster teachers, and parents using techniques SFBT (Solution Focus Brief Therapy) approach, namely, focusing on solving problems being experienced by students.
Analisis Kesulitan Belajar Mahasiswa Pada Elektronika Dasar Blanded Learning
Authors: Sinta Sinta , Rahmasari Sitti
Published: January 2025

Penggunaan Blanded Learning pada mata kuliah elektronika dasar sudah dilaksanakan di Program Studi Tadris Fisika Universitas Antasari. Tujuan penelitian ini untuk mengetahui kesulitan belajar mahasiswa dalam berinteraksi, memahami materi, berkonsentrasi, mengajarkan tugas/ujian. Manfaat penelitiannya untuk mencarikan alternatif untuk mengatasi permasalahan kesulitan belajar pada mahasiswa. Metode penelitiannya deskriptif kuantitatif dengan analisis statistic deskriptif yang menampilkan grafik, distribusi frekuensi, dan tabel. Teknik pengumpulan data menggunakan angket dengan 22 butir penyataan positif dan negative yang disebarkan secara online melalui WhatsApp yang berbentuk Google Form. Subjek dalam penelitian terdapat tiga indicator kesulitan belajar, yang paling tinggi kesulitan dialami mahasiswa dalam memahami materi dengn indeks persen 70,24% dan kesulitan belajar paling rendah dalam berkonsentrasi karena indeks 58,45%.
STRUCTURAL AND HEMODYNAMIC CHANGES ON ECHOCARDIOGRAPHY IN BETA-THALASSEMIA MAJOR PATIENTS
Authors: Khan Muhammad Asif Nawaz , Fazlul Aziz Mian  , Subaat Basit  , Bilqees  , Laiba Sarfraz  , Shahjahan Wahid
Published: January 2025

Background: Beta-thalassemia major is a hereditary blood disorder requiring lifelong blood transfusions, which lead to iron overload and associated complications, particularly cardiac dysfunction. Myocardial iron deposition is a significant cause of morbidity and mortality in these patients, often resulting in structural and functional cardiac abnormalities. Echocardiography is a crucial non-invasive tool for early detection of cardiac changes, allowing timely intervention. Understanding the relationship between serum ferritin levels and cardiac parameters can help optimize management strategies for affected individuals.
Objective
This study aimed to evaluate the structural and functional cardiac changes in children with beta-thalassemia major and examine the association between these changes and serum ferritin levels.
Methods: A cross-sectional study was conducted over six months at the Department of Cardiology, Pakistan Institute of Medical Sciences (PIMS), Islamabad. A total of 85 children aged 2–14 years with a confirmed diagnosis of beta-thalassemia major and a history of more than ten packed red blood cell transfusions were included. Demographic, clinical, and hematological data were collected, along with echocardiographic assessments of left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF), and the E/A ratio. Serum ferritin levels were measured, and statistical analysis was performed using SPSS version 26, with a significance threshold of p ≤ 0.05.
Results: The mean hemoglobin level was 8.5 ± 1.2 g/dL, while serum ferritin averaged 2500 ± 850 ng/mL, indicating severe iron overload. Echocardiographic parameters showed a mean LVEDD of 42.3 ± 3.5 mm, LVESD of 28.1 ± 2.7 mm, and LVEF of 56.8 ± 6.5%. Patients with ferritin levels ≥2500 µg/L had significantly larger LVEDD (44.5 ± 3.2 mm vs. 40.1 ± 3.0 mm, p = 0.05), LVESD (30.2 ± 2.5 mm vs. 26.0 ± 2.4 mm, p = 0.01), and lower LVEF (54.0 ± 5.8% vs. 59.6 ± 5.2%, p = 0.03). Positive correlations were found between ferritin and LVESD (r = +0.50), while an inverse correlation was observed with LVEF (r = -0.48). No significant difference in the E/A ratio was noted (p = 0.15).
Conclusion: The findings indicate that children with beta-thalassemia major experience significant cardiac structural changes, with increased LVEDD, LVESD, and reduced LVEF closely linked to elevated serum ferritin levels. These results highlight the detrimental effects of iron overload on cardiac performance, emphasizing the need for more effective chelation therapy and cardiac monitoring strategies to prevent early myocardial dysfunction.
EXAMINING UNDERGRADUATE STUDENTS’ AWARENESS, ATTITUDES, AND ACTIONS TOWARD VOLUNTARY BLOOD DONATION
Authors: Chauhan Amish , Abu Anas  , Faisal Nadeem  , Warda Tu Nisa  , Jerry Zahid
Published: January 2025

Background: Voluntary blood donation is a critical component of healthcare systems, ensuring the availability of safe blood for transfusions and life-saving interventions. The World Health Organization recommends that at least 1% of a country's population should donate blood to meet the global demand. Despite this, low-income countries, including Pakistan, face acute shortages due to misinformation, cultural myths, and unfavorable attitudes that discourage participation. Understanding the awareness, perspectives, and behaviors surrounding blood donation among young adults is essential to address these challenges effectively.
Objective: This study aimed to evaluate the awareness, perspectives, and actual donation practices of undergraduate students regarding voluntary blood donation. It further sought to identify key factors influencing their participation and explore the relationships among awareness, attitudes, and behaviors to inform targeted interventions.
Methods: A cross-sectional study design was employed, involving 197 undergraduate students aged 17–35 years. Data were collected through an online questionnaire distributed across multiple academic departments to ensure a diverse sample. The questionnaire assessed awareness, perspectives, and behaviors related to blood donation. Descriptive statistics, correlation analysis, and hypothesis testing were performed using SPSS version 23 to analyze the data. Key variables were explored for their interrelationships, focusing on awareness levels, attitudes, and donation behaviors.
Results: The study revealed that 27.9% of participants (55 out of 197) had donated blood voluntarily. Awareness was generally high, with 85.8% knowing their blood group, while 10.2% were unfamiliar with it. However, only 42.6% were aware of the storage duration of blood, indicating knowledge gaps. Positive attitudes toward donation were evident, with 91.9% supporting the idea of blood donation and 82.7% expressing willingness to donate in the future. A statistically significant positive correlation (r = 0.257, p < 0.01) was found between awareness and attitudes, while awareness and actual donation behavior demonstrated a minimal correlation (r = 0.014, p = 0.843).
Conclusion: The findings highlight a significant gap between positive attitudes and actual donation practices among students. Targeted educational programs addressing misconceptions and logistical barriers, along with strategies to translate awareness into action, are essential to increase voluntary blood donation rates. These measures can support a sustainable and safe blood supply for healthcare needs.
Planejamento para Controle e Eliminação da Tuberculose no Estado do Rio de Janeiro
Authors: Barbosa Claudia
Published: January 2025

O desafio da eliminação da tuberculose no estado do Rio de Janeiro recebe, até 2026, um fomento que tem como diferencial histórico unir especialistas a recursos financeiros dimensionados para implementar estratégias capazes de alcançar o controle progressivo e definitivo do agravo. A arquitetura deste empenho está refletida no Termo de Cooperação firmado entre Ministério de Saúde, Secretaria do Estado do Rio de Janeiro e Organização Pan-americana da Saúde, e conta com o apoio da Assembleia Legislativa do Estado do Rio de Janeiro e firme propósito da sociedade civil. Focado em 16 municípios mais críticos e unidades prisionais do estado, e refletindo a determinação socioeconômica da tuberculose, o desenho do Termo prevê ações e resultados em quatro áreas: Rede de Atenção à Saúde, Proteção Social, Vigilância Epidemiológica, além de Inovação, Pesquisa e Tecnologia. Este planejamento da Cooperação Técnica visa, ao término do fomento, obter resultados sustentáveis. Ter êxito na sustentabilidade, entretanto, exige visão de longo prazo orientadora, de modo a não se deixar levar pela premência das carências múltiplas, e engajar-se na estruturação, fortalecimento e integração estratégica de pilares que garantam robustez na aplicação dos recursos, a saber: Governança/Gestão; Direcionamento Estratégico; Monitoramento/Avaliação de Resultados; Comunicação; e, Análise/Mitigação de riscos.
Bioaccumulation of copper and its effects on growth and biochemical parameters in bitter gourd (Momordica charantia) plants
Authors: Mani Vijay , Raman Amudhavadhani , Ravikumar Anusha
Published: January 2025

Heavy metal pollution has increased broadly over the globe due to industrial, anthropogenic activities and modern industrialization. Disturbing the environment which leads to causing various health hazards to our humankind. The present study is aimed to evaluate the bioaccumulation of copper and its effects on growth and biochemical parameters in Bitter Gourd (Momordica charantia L.) plants. Group 1 plants in polyethylene bag with soil served as control not received copper treatment, groups 2, 3 and 4 received copper treatment of 100, 200 and 400 mg throughout the experimental period. Our results revealed significant reduction in growth parameters such as germination percentage, root length, shoot length, fresh weight, dry weight and vigour index, biochemical parameters such as carbohydrate and protein contents and enzymic antioxidants such as catalase and super oxide dismutase, under copper treatment at various concentrations showed heavy metal toxicity in Bitter gourd plants. Therefore, it is essential to meticulously regulate the copper content in the soil to prevent any negative impacts on the growth and development of plants.
Penerapan Metode Muroja’ah Dalam Menghafal Al-Qur’an
Authors: Lauchia Rara , Dwi Fazza Erwina , Ahmad Mulyadi
Published: January 2025

Al-Qur'an is a guide to life for Muslims. Memorizing and reading the Qur'an is one of the suggestions commanded by Allah SWT to the people of the Prophet Muhammad SAW. For those who read one letter of the Qur'an, he will get 10 goodness. The purpose of this research is to find out the importance of learning the Koran, Fadhilah reading the Koran, the method of memorizing the Koran and the application of the muroja'ah method in memorizing the Koran. The method used in this research is the library research method. The result is that the application of the muroja'ah method in memorizing the Al-Qur'an is very easy to do so we are happy to memorize the Al-Qur'an. In this method, we not only memorize verses of the Qur'an, but we also know the contents of the verses of the Qur'an so that it is easier to implement in everyday life. In our opinion, this method is very helpful for those who want to memorize the Al-Qur'an so that it is easier, insha Allah.
Call for papers - Algebraic practice in classrooms and beyond
Authors: Kilhamn Cecilia
Published: January 2025

To meet the needs of the 21st century societies it is necessary to change the nature of algebra teaching. Challenges such as climate change and pandemics require understanding of patterns of growth and change of complex systems, and engaging in public discourse about these challenges requires the ability to argue in general terms about abstract quantities. Algebra is the area of mathematics focusing on generalization, but for many people, school algebra consists of rearranging strings of symbols qccording to rules, without developing the ability to reason with generalizations. There is a need for approaches to algebra learning and teaching that develop the ability to use generalizations to describe, analyze and solve problems in real life, as well as within mathematics, an ability we call ”algebraic practice”.
Autonomous vehicles in road traffic
Authors: Ribarić Boris Z. , Rajilić Snježana , Ribarić Zoran
Published: January 2025

The tendencies in further technological development and across all branches of industry are well-known worldwide, with a focus on the advancement of robotics and artificial intelligence. Over the years, there has been significant progress in the development of robotics, coupled with increased human awareness of its potential applications. Consequently, we find ourselves in a period where the commercialization and widespread utilization of artificially intelligent machines in human environments have become a reality. Among the significant applications of robotics in human lives is the utilization of robotic vehicles, commonly referred to as autonomous vehicles, in traffic management. The implementation of new technologies aims to address various challenges in transportation, including congestion reduction, cost optimization, safety enhancement, and mitigation of environmental impact. This endeavor involves the integration of telecommunications, electronics, and informatics with traffic engineering principles for effective planning, design, and management of traffic systems. Such integration leads to improved efficiency and safety within the traffic system, while also yielding positive environmental outcomes.
Hijos biógrafos, padres biografiados: una lectura de "Nuestro peor fracaso", de Cristian Godoy
Authors: Fontana Patricio
Published: January 2025

En este artículo propongo un análisis de Nuestro peor fracaso, de Cristian Godoy, como ejemplo de un tipo de escritura biográfica que en los últimos años ha proliferado en la Argentina: textos en los que un hijo cuenta la vida de su padre y la relación que ambos mantuvieron. El análisis del libro de Godoy me permite avanzar en la indagación de algunos rasgos de este subgénero biográfico cuya emergencia se remonta a la primera década del siglo xx que ya inicié en algunos trabajos previos a este. Entre esos rasgos aquí me focalizo especialmente en tres: (1) la índole relacional de estos textos, (2) cómo en ellos se negocia el vínculo entre biógrafo y biografiado y (3) cómo desestabilizan la oposición entre vida y muerte para constituirse en algo más que formas de tramitar el duelo. Asimismo, aquí esbozo alguna hipótesis preliminar respecto de cómo estos textos se instalan en relación con las discusiones sobre el patriarcado que caracterizan nuestra contemporaneidad.
"Recoged esta voz": aportaciones de la semiótica para el estudio de las musicalizaciones. El caso de Miguel Hernández en la canción de autor española (1960-1980)
Marta Covisa
Authors: Covisa Andarias Marta
Published: January 2025

Este artículo pretende ahondar en las relaciones que, ya desde sus orígenes, han mantenido poesía y música, tomando como enfoque los marcos teóricos contemporáneos que nos brindan la intermedialidad y la semiótica. El objetivo pasa por señalar y delimitar distintos condicionantes semióticos relevantes para el estudio de la trasposición poesía-música, que apuntan a la canción como producto cultural y ponen en evidencia la necesidad del estudio de la función sociocomunicativa del texto (lírico y musical) para su interpretación. En este sentido, se destaca el interés que suscita tal estudio con el ejemplo de la canción de autor en España durante los últimos años del franquismo y la Transición, dado el afán de compromiso social que presentaba. De manera más concreta, se ofrece una aproximación panorámica a la musicalización por parte de estos artistas de la obra de Miguel Hernández, buscando así resaltar la importancia de los elementos extratextuales en el fenómeno intermedial, y concluir así en la efi cacia de la noción propuesta por Iuri Lotman del texto como “memoria cultural colectiva”.
Intragovernmental governance in South Africa - An analysis of recent jurisprudence
Authors: SJ Karsten Andreas , van der Bank Marjoné
Published: January 2025

In the South African local government domain, municipalities’ ability to execute legislative and executive powers is vested in municipal councils (section 151(2) of the Constitution of the Republic of South Africa, 1996). Given the importance of a municipal council from a functionality perspective, any suspension of executive or legislative decision-making powers can impede the realization of municipal councils’ constitutional purpose, specifically, the objective to provide democratic and accountable governance to local communities. In recent years, local coalition governments have been seen more frequently, partly due to the number of hang councils in South Africa. Governance suffers because of the resulting volatility caused by political standoffs. The departing premise hereto is that the realization of a democratic and accountable government depends on the degree of functionality of every municipal council. Conversely, in councils, volatility can adversely compromise democratic and accountable governance. During recent years, coalition governments in local government have been seen more frequently, partly due to the number of hung councils in South Africa. This article builds on the legal insight provided in the case of the Premier, Gauteng and Others v Democratic Alliance and Others; All Tshwane Councillors who are Members of the Economic Freedom Fighters and Another v Democratic Alliance and Others; African National Congress v Democratic Alliance and Others [2021] ZACC 34. The authors considered using governance mechanisms to provide better support and guidance to ensure the continuation of democratic and accountable government practices, where fractured coalitions have caused governance fallouts in municipal councils.
On Theological, Philosophical and Sociological Themes
Authors: Ceccoli Crimi Davide
Published: January 2025

The article is the report of an attempt to connect Manlio Sgalambro, philosopher and theologian, standard-bearer of “negative theology”, with Luigi Moraldi, hermeneutist and exegete of the “gnostic texts”, who was part of the international team of translation of the Nag-Hammadi manuscripts. The meeting did not take place, but it remains a correspondence of great interest both for the contents it deals with and for the specific approaches of the two great intellectuals on the subject that, even in the present of this 21st century, continues to be overwhelming for the general system of knowledge.
Sphingosine-1-phosphate signaling regulates the ability of Müller glia to become neurogenic, proliferating progenitor-like cells
Authors: Taylor Olivia , DeGroff Nick , El-Hodiri Heithem , Gao Chengyu , Fischer Andy J
Published: January 2025

The purpose of these studies is to investigate how Sphingosine-1-phosphate (S1P) signaling regulates glial phenotype, dedifferentiation of Müller glia (MG), reprogramming into proliferating MG-derived progenitor cells (MGPCs), and neuronal differentiation of the progeny of MGPCs in the chick retina. We found that S1P-related genes are highly expressed by retinal neurons and glia, and levels of expression were dynamically regulated following retinal damage. Drug treatments that activate S1P receptor 1 (S1PR1) or increase levels of S1P suppressed the formation of MGPCs. Conversely, treatments that inhibit S1PR1 or decrease levels of S1P stimulated the formation of MGPCs. Inhibition of S1P receptors or S1P synthesis significantly enhanced the neuronal differentiation of the progeny of MGPCs. We report that S1P-related gene expression in MG is modulated by microglia and inhibition of S1P receptors or S1P synthesis partially rescues the loss of MGPC formation in damaged retinas missing microglia. Finally, we show that TGFβ/Smad3 signaling in the resting retina maintains S1PR1 expression in MG. We conclude that the S1P signaling is dynamically regulated in MG and MGPCs in the chick retina, and activation of S1P signaling depends, in part, on signals produced by reactive microglia.
Flexibility in PAM Recognition Expands DNA Targeting in xCas9
Authors: Hossain Kazi A , Nierzwicki Lukasz , Orozco Modesto , Czub Jacek , Palermo Giulia
Published: January 2025

xCas9 is an evolved variant of the CRISPR-Cas9 genome editing system, engineered to improve specificity and reduce undesired off-target effects. How xCas9 expands the DNA targeting capability of Cas9 by recognizing a series of alternative Protospacer Adjacent Motif (PAM) sequences while ignoring others is unknown. Here, we elucidate the molecular mechanism underlying xCas9’s expanded PAM recognition and provide critical insights for expanding DNA targeting. We demonstrate that while wild-type Cas9 enforces stringent guanine selection through the rigidity of its interacting arginine dyad, xCas9 introduces flexibility in R1335, enabling selective recognition of specific PAM sequences. This increased flexibility confers a pronounced entropic preference, which also improves recognition of the canonical TGG PAM. Furthermore, xCas9 enhances DNA binding to alternative PAM sequences during the early evolution cycles, while favouring binding to the canonical PAM in the final evolution cycle. This dual functionality highlights how xCas9 broadens PAM recognition and underscores the importance of fine-tuning the flexibility of the PAM-interacting cleft as a key strategy for expanding the DNA targeting potential of CRISPR-Cas systems. These findings deepen our understanding of DNA recognition in xCas9 and may apply to other CRISPR-Cas systems with similar PAM recognition requirements.
SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent state
Authors: Sebastian-Perez Ruben , Nakagawa Shoma , Tu Xiaochuan , Aranda Sergi , Pesaresi Martina , Gomez-Garcia Pablo Aurelio , Alcoverro-Bertran Marc , Gomez-Vazquez Jose Luis , Carnevali Davide , Borràs Eva , Sabidó Eduard , Martin Laura , Nissim-Rafinia Malka , Meshorer Eran , Neguembor Maria Victoria , Di Croce Luciano , Cosma Maria Pia
Published: January 2025

Chromocenters are established after the 2-cell (2C) stage during mouse embryonic development, but the factors that mediate chromocenter formation remain largely unknown. To identify regulators of 2C heterochromatin establishment, we generated an inducible system to convert embryonic stem cells (ESCs) to 2C-like cells. This conversion is marked by a global reorganization and dispersion of H3K9me3-heterochromatin foci, which are then reversibly formed upon re-entry into pluripotency. By profiling the chromatin-bound proteome (chromatome) through genome capture of ESCs transitioning to 2C-like cells, we uncover chromatin regulators involved in
de novo
heterochromatin formation. We identified TOPBP1 and investigated its binding partner SMARCAD1. SMARCAD1 and TOPBP1 associate with H3K9me3-heterochromatin in ESCs. Interestingly, the nuclear localization of SMARCAD1 is lost in 2C-like cells. SMARCAD1 or TOPBP1 depletion in mouse embryos leads to developmental arrest, reduction of H3K9me3, and remodeling of heterochromatin foci. Collectively, our findings contribute to comprehending the maintenance of chromocenters during early development.
Nutritional Potential and the Effect of Ethanol and Aqueous Extracts of Plukenetia conophora Leaf on the Body Weight and Blood Glucose Concentrations of Diabetic Rats
Authors: Okoroh Prince, N. , Orieke Daniel , Ekeke Kelechi Light , Osuji Chigoziri, A. , Benedeth Adjeyakpo Ejiroghene
Published: January 2025

Proximate composition and energy value, macro-mineral concentration, percentage daily value (%DV), nutrient rich index (NRI) and the effect of ethanol and aqueous extracts of Plukenetia conophora leaves on the body weight and blood glucose concentration of diabetic rats were determined using standard methods. The pharmacological model was 120mg/kg b.w. (via intraperitoneal) alloxan monohydrate induced diabetic rat model, with the ethanol and aqueous extracts respectively administered orally at 200mg/kg and 500mg/kg respectively and glibenclamide administered as reference control at 5mg/kg b.w. Chemical analysis showed that all the samples were rich in crude fiber (17.7%;%DV:63.21), ash (11.57%) , carbohydrate (57.14%; %DV:47.71), energy (254.05Kcal/100g; %D.V.:19.96). Spectrophotometric analysis data revealed Potassium concentration (68.07mg/kg; %DV:1.45) as highest while Sodium concentration (0.51mg/kg;%D.V.:0.02) was the lowest. The potassium to sodium ratio was high (136.1) while the sodium to potassium ratio was very low (0.008) and these ratios shows that the leaf may have positive effect on cardiovascular health. Nutrient Rich Index (NRI) based on macronutrients and macro minerals was estimated to be 16.47. Data on the effect of the ethanol extract and aqueous extract of the leaves of P. conophora on the body weight and blood glucose level of the rats revealed that the extracts significantly (p< 0.05), time and dose dependently restored the body weights towards normal compared to the diabetic control. The extracts also significantly (p< 0.05), time and dose dependently lowered blood glucose concentration towards normal compared to the treated rats. The nutritional and nutraceutical potential of the leaves of P. conophora as shown in this study suggest its possible use in food as cheap, effective and safe anti -diabetic agent for the management of diabetes mellitus and its associated complications.
Urinary Albumin-to-Creatinine Ratio in Normal Range, Cardiovascular Health, and All-Cause Mortality
Authors: Mahemuti Nayili , Zou Jiao , Liu Chuanlang , Xiao Zhiyi , Liang Fengchao , Yang Xueli
Published: December 2023

Importance

Although cumulative evidence suggests that elevated urinary albumin-to-creatinine ratio (UACR) in the normal range (<30 mg/g) may be associated with an increased risk of mortality, few studies have investigated whether cardiovascular health (CVH) modifies the harmful outcomes of high-normal UACR.

Objective

To investigate associations of traditionally normal UACR and CVH with all-cause mortality.

Design, Setting, and Participants

This cohort study used National Health and Nutrition Examination Survey data from 2005 through 2018 and linked mortality information until 2019. Data were analyzed from March 1 through October 31, 2023. The study included adult participants aged 20 to 79 years with a normal UACR (<30 mg/g) based on Kidney Disease: Improving Global Outcomes criteria.

Exposures

The UACR was treated as a continuous variable and categorized into tertiles delineated as low (<4.67 mg/g), medium (4.67-7.67 mg/g), and high (7.68 to <30 mg/g). Cardiovascular health was assessed using Life’s Essential 8 scores and grouped as poor (0-49 points), moderate (50-79 points), and ideal (80-100 points).

Main Outcomes and Measures

Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% CIs for associations of UACR with all-cause mortality in total participants and as stratified by CVH groups.

Results

The study included 23 697 participants (mean [SD] age, 45.58 [15.44] years; 11 806 women [49.7%] and 11 891 men [50.3%]). During the median 7.8 years (range, 4.5-11.1 years) of follow-up, 1403 deaths were recorded. Near-linear associations were observed for continuous UACR and CVH with all-cause mortality. Compared with the low UACR group, high UACR in the normal range showed an increased mortality risk in the moderate and poor CVH groups (CVH [50-79]: HR, 1.54 [95% CI, 1.26-1.89]; CVH [0-49]: HR, 1.56 [95% CI, 1.10-2.20]), with a significant multiplicative interaction of UACR and CVH (P < .001).

Conclusions and Relevance

The findings suggest that high UACR within the normal range is associated with a significantly increased risk of all-cause mortality, with the association more pronounced in adults with poor CVH status. These findings highlight the importance of risk management for early kidney dysfunction, particularly among individuals with poor CVH.