bluuebunny/crossref_metadata_2025 huggingface dataset:
Mathematical Logic Demonstration of Computational Model of Audiovisual Works
Authors: hao jiangfeng
Published: March 2022

Abstract: Mathematics plays an irreplaceable role in human historical
development and social life. Mathematics is a universal means for human
beings to strictly describe the abstract structures and patterns of
things, and can be applied to any problem in the real world. Therefore,
the same applies to legal issues in the social sciences. In the field of
intellectual property law, where law and science and technology are
relatively closely integrated, the substantive similarity of
audio-visual works has always been in qualitative analysis, while the
increasingly perfect rule of law society and the increasingly high-speed
commercial activities require legal work to be provided under the
premise of stability. The boundary between number and quantity is clear.
At this time, the Ministry of Education proposed to promote the
construction of new liberal arts education. As a basic subject of
natural science, mathematics, of course, should be at the forefront of
subject integration. Mathematics’ solution to problems is nothing more
than direct arithmetic solution, and indirect transformation
(transformed into currently solvable) solution. At the same time, with
the introduction and development of the concept of computational law in
the field of law, the past tense of computational law and the
development of computational law should have its own development
results.
Landing manoeuvres predict roost-site preferences in bats
Authors: Chaverri Gloriana , Araya-Salas Marcelo , Barrantes Jose Pablo , Uribe-Etxebarria Tere , Peña-Acuña Marcela , Varela Angie , Aihartza Joxerra
Published: March 2022

Roosts are vital for the survival of many species, and how individuals
choose one site over another is affected by various ecological factors.
Biomechanical constraints could also affect roost selection,
particularly in volant taxa that require sites with easy access, thereby
reducing costs (i.e., predation, accidents). To date, no studies have
established an association between landing performance and roost-site
selection, as predicted by biomechanical constraints associated with
flight. We aim to determine roost-site selection in disc-winged bats
(Thyroptera tricolor), a species known to roost within developing
tubular leaves. This study is coupled with various experiments that
measure how a conspicuous apex affects landing tactics and performance.
We show that T. tricolor prefers leaves with a longer apex, the
space typically used for landing. Bats also approach and enter these
leaves more consistently, increasing task performance while reducing the
risk of injuries.
COVID-19-Associated Multisystem Inflammatory Syndrome with skin lesions after induction in AML pediatric patient: A case report
Authors: Mota Fernanda , Sousa Ana de , Silva Adriana , Silva Dafne Bourguignon da , Piotto Daniela , Carlesse Fabianne
Published: March 2022

Severe SARS-CoV-2 infections in pediatrics are rare and usually
presented as multisystem inflammatory syndrome in children. There are
few descriptions about pediatric oncology patients. We describe a case
of 5-year-old male with acute myeloid leukemia. He presented febrile
neutropenia with skin lesions and progressive clinical worsening. He had
positive RT-PCR test for SARS-CoV-2 and criteria for MIS-C. He received
methylprednisolone, immunoglobulin and granulocyte-colony-stimulating
factor. Anti-interleukin 6 was administrated due to severe lung disease
and refractory to treatment, presenting response and slow clinical
recovery. Chemotherapy was restarted, he didn’t present relapse during
treatment and has no sequelae of COVID-19.
The effects of maternal stature and race/ethnicity on adverse birth outcomes; A retrospective cohort study
Authors: Yearwood Lauren , Bone Jeffrey , Wen Emma , Muraca Giulia , Lyons Janet , Razaz Neda , Joseph K S , Lisonkova Sarka
Published: March 2022

Objective: To examine the association between maternal stature and
adverse perinatal outcomes, and the modifying effect of race/ethnicity.
Design: Retrospective cohort study. Settings: USA, 2016-2017.
Population: Women with a singleton stillbirth or livebirth
(N=7,361,713). Methods: Using data from the National Center for Health
Statistics, short and tall stature were defined as <10th and
>90th centile of the maternal height distribution. Logistic
regression was used to obtain adjusted odds ratios (AOR) and 95%
confidence intervals (CI). Main Outcome Measures: Preterm birth (PTB,
<37 weeks’ gestation), perinatal death, and the composite of
perinatal death/severe neonatal morbidity (PD/SNM). Results: Short women
had elevated risk of adverse outcomes, while tall women had a decreased
risk relative to average stature women. Short women had an increased
risk of perinatal death and PD/SNM (AOR=1.14, CI: 1.10-1.17; AOR=1.21,
CI: 1.19-1.23, respectively). The association between short stature and
perinatal death was attenuated in non-Hispanic Black women compared with
non-Hispanic White women (AOR=1.10, 95% CI 1.03-1.17 vs AOR=1.26, CI
1.19-1.33). Compared with women of average stature, tall non-Hispanic
White women had lower rates of PTB, PD/SNM (AOR=0.82, CI 0.81-0.83;
AOR=0.95, CI 0.91-1.00; AOR=0.90, CI 0.88-0.93, respectively).
Conclusion: Relative to women of average stature, short women have an
increased risk of adverse perinatal outcomes; these effects are
attenuated in Hispanic women, and for some adverse outcomes in
non-Hispanic Black women. All tall women have a lower risk of preterm
birth, and tall non-Hispanic White women have also lower risk of
perinatal death/severe neonatal morbidity.
Inference of metabolic fluxes in nutrient-limited continuous cultures: A Maximum Entropy Approach with minimum information
Authors: Pereiro Jose , Fernandez-de-Cossio-Diaz Jorge , Mulet Roberto
Published: March 2022

The study of cellular metabolism is often hindered by limitations in the
amount of exper- imental data available. Therefore computational methods
that exploit maximally the possible measurements, and are able to
extract relevant predictions from a minimum of information are always
welcome. Maximum Entropy (ME) inference has been succesfully applied to
genome-scale models of cellular metabolism in various cell culture
contexts, yielding insights into biologically relevant properties which
are not accessible to traditional optimization based methods. Recent
data-driven studies have suggested that in chemostat cultures, the
growth rate and uptake rates of limiting nutrients are the most
informative parameters about the metabolism. In this work, we propose
the thesis that chemostat dynamics typically drives the culture towards
maximally restricted metabolic states. A practical consequence is that
experimental values of limiting up- take rates can be replaced by more
readily available measurements of metabolite concentrations in the feed
media and the steady state cell concentration. We show how these results
can be justified from a mechanistic perspective by studying simulations
of a simplified model where we test the quality of the inference, and
unveil the mechanisms defining the performance of our approach. We then
apply our method to E. coli experimental data. We evaluate the effects
of heterogeneity in chemostat cultures and its potential impact on flux
inference quality of ME and optimization based strategies. Additionally,
we evaluate the quality of the inference comparing M E to alternative
formulations that rest on a Flux Balance Analysis (F BA).
Ciprofloxacin-Induced Thrombotic Thrombocytopenic Purpura: a case report with fatal outcomes
Authors: Boumaiza Sirine , Aounallah Amina , Ferhi Fehmi , Sfar Ahlem , Mokni Sana , Ghariani Najet , Belajouza Colandane , Denguezli Mohamed
Published: March 2022

Thrombotic Thrombocytopenic Purpura is a particular form of thrombotic
microangiopathy, characterized by petechial lesions, anemia, renal
failure and fluctuating mental status. It is usually associated with an
infection, drugs, or neoplasias. Confusing and rare, it is a real
diagnostic challenge.
The Fate of the Sea as Determined by Geopolitical Relationships: Exploring Centralized Governance Over the World’s Largest Common-Pool Resource
Authors: Mooney Henry N. , Jr. Miguel A. Cardenas , Cardenas Miguel A.
Published: March 2022

Abstract: This work sheds light on the centralized nature of ocean
governance and the symptomatic expenses borne by marine natural capital
and smaller scale ocean users alike, such as artisanal fishermen.
Considering the weak representation on the topic within formal academic
circles, phenomena are primarily thread from grey and secondary sources
into a supportive theoretical work regarding oceanic spatial
appropriation from the federal governments of the world’s coastal
states. It is argued that the marginalization of the world’s coastal
poor and ecological depletion in part result from the top-down nature of
managing marine resources, and that the fate of nearly all sea life is
in large part at the hands of geopolitical relationships.
WeChat-based health communication interventions enhance knowledge, protective attitudes and behavior intentions towards canine rabies in Shandong, China
Authors: Zhang Weichao , Lan Zouran , Magalhaes Ricardo Soares , Sun xiangdong , Zhu Xingjun , Wu Hairong
Published: March 2022

Introduction: In order to provide refined effects analysis of
health communication intervention, this study aims to measure and
compare the impact on the knowledge and protective attitudes and
behavior intentions(KAP) towards canine rabies of interventions that use
the local TV net(V1) and WeChat platform (V2) delivering a short video,
and cartoon pamphlet(P). Materials and Methods: The study used a
between-subject design involving repeated measures of rabies-related
KAP. 800 randomly selected villagers were randomly allocated into four
intervention groups (V1, V2, P and V2+P) and one control. The content of
video and pamphlet covered topics about rabies prevention, route of
transmission, and so on. The pamphlet was given door to door once
immediately after the pretest. One day after the pretest, the same video
was posted one time through WeChat platform, and was broadcasted via
local TV net two times each day in consecutive fifteen days. A validated
questionnaire was used to capture demographic and KAP information.
Ordinary Least Squares regression was used to contrast the effects of
interventions. Results: Our results indicate that overall V2
outperforms V1 but underperforms P at improving KAP scores. Our results
suggest that a combined intervention of V2 and P can result in higher
scores than any of the two in isolation. The impact on the knowledge,
protective attitudes and behavior intentions scores is revealed in a
decreasing sequence. Conclusion: This study demonstrated that
health communication modes based on V1, V2, P and a combination of the
two are all effective to improve rabies-related KAP in the short term.
These findings provide a scientific basis for the implementation of
health communication intervention toward rabies and further studies are
needed to investigate the long term and other social media message
elements benefits of these interventions on the reduction of rabies
incidence in humans.
Which fetal biometry charts should be used? A large validation study in mainland China
Authors: zhao jianxin , Yuan Ying , Tao Jing , Chen Chunyi , wu xiaoxia , Liao Yimei , wu linlin , Zeng Qing , Chen Yin , Wang Ke , Li Xiaohong , Liu Zheng , Zhou Jiayuan , Zhou Yangwen , Li Shengli , Zhu Jun
Published: March 2022

Objective: To assess the impact of applying published fetal growth
references or standards in the Chinese mainland population and to
compare their ability to predict newborns small- for- gestational- age
(SGA). Design: Retrospective observational study. Setting: A tertiary
hospital in Shenzhen, a Chinese city with the most immigrants.
Population: All pregnant women (n=106,455) who booked for prenatal care
with ultrasound measurements for fetal biometry between 2012 and 2019.
Methods: A fractional polynomial regression model was applied to
construct Shenzhen fetal growth chart ranges for HC, BPD, AC, and FL.
The differences between Shenzhen charts and published charts were
quantified by calculating the Z-score. Main outcome measures: The impact
of applying these published charts was quantified by calculating the
proportions of fetuses with biometric measurements below the 3rd centile
of these charts. The sensitivity and area under the receiver operating
curves of published charts to predict neonatal SGA (birthweight
<10th centile) were assessed. Results: Following selection,
169,980 scans of fetal biometry contributed by 41,032 pregnancies with
reliable gestational age were analyzed. When using Hadlock references
(<3rd), the proportions of small heads and short femurs were
as high as 8.9% and 6.6% in late gestation, respectively. The
Intergrowth-21st standards matched those of our observed curves better
than other charts. When using AC<10th centile, all of these
references were poor at predicting neonatal SGA. Conclusion: Applying
Hadlock references could possibly misclassify a large proportion of
fetuses as SGA. Conversely, applying the Intergrowth-21st standard
appears to be a safe option in mainland China.
Determination of the proteins and pathways involved in the anti-breast cancer activity of glycyrrhizin from a bioinformatics point of view
Authors: Poustforoosh Alireza , Faramarz Sanaz , Negahdaripour Manica , Hashemiour Hassan
Published: March 2022

The anti-cancer activity of glycyrrhizin (licorice) against various
types of breast cancer (BC) has been reported so far. However, a
complete investigation for understanding the pathways that could be
affected by this herbal compound as an anti-breast cancer agent has not
been performed yet. This study tends to investigate the proteins and
pathways involved in the anti-BC activity of glycyrrhizin. For this
purpose, the target genes of glycyrrhizin were obtained from the ChEMBL
database. The BC-associated genes for three kinds of BC were retrieved
from DisGeNET. The target genes of glycyrrhizin and the BC-associated
genes were compared, and the genes with disease specificity index (DSI
> 0.6) were selected for further evaluation using in
silico methods and bioinformatics tools. The protein-protein
interaction (PPI) network was constructed, and Gene Ontology (GO) and
Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were analyzed.
The results revealed 80 common genes among the glycyrrhizin target genes
and breast carcinoma-associated genes. Ten genes had a DSI greater than
0.6. The binding affinity of glycyrrhizin to these proteins and binding
characteristics were assessed using molecular docking and binding free
energy calculations (MM/GBSA). POLK, TBXAS1, and ADRA1A showed the
highest binding affinity with -8.9, -9.3, and -9.6 kcal/mol,
respectively. ErbB signaling pathway and PD-L1 expression and PD-1
checkpoint pathway in cancer are the potent pathways for the anti-BC
activity of glycyrrhizin. By affecting the obtained targets and
modulating the mentioned pathways, glycyrrhizin can influence and
control BC efficiently.
COTRIMOXAZOLE INDUCED HYPERKALEMIA
Authors: Srikaram Prakhyath , Siddiqui Amna , Gul Fahad , Deuja Puja , Fatima Nabeela
Published: March 2022

We present the case of a 55-year old male patient who developed
hyperkalemia after using Cotrimoxazole(TMP-SMX).He developed an elevated
level of potassium from day-4 which kept on increasing until the drug
was withheld on day-8.There was a marked increase in levels from
3.0(baseline) to 6.2 before the drug was withheld.
Congenital absence of left coronary artery: a case report and literature review
Authors: YANG YANG , Wu Fang qin , jiang xinghua
Published: March 2022

Single coronary artery (SCA) is defined as an isolated coronary artery
that arises from a single coronary ostium and provides blood supply to
the entire myocardium. At present, the absence of the right coronary
artery is more common in SCA and the absence of the left coronary artery
is rare. We report a case of a middle-aged man with congenital left
coronary artery absence. The patient underwent coronary angiography
after completing relevant examinations on admission, the results showed
that the coronary artery blood supply was dominant in the right coronary
artery; the right coronary artery was compensatively thickened and long,
the part of the left coronary artery that functions as the anterior
descending branch opens at the beginning of the right coronary artery
and the blood vessels were small. The patient was given symptomatic
supportive treatment during the hospitalization period and was
discharged from the hospital. The patient’s condition was stable during
the follow-up. This case demonstrates that although congenital left
coronary artery absence is a rare disease, correct diagnosis,
appropriate treatment and patient education play a vital role in the
treatment of these patients.
Lesion Size Index (LSI)–guided catheter ablation for atrial fibrillation: can tissue impedance drop help to identify desirable ablation settings and target indices?
Authors: Leo Milena , Banerjee Abhirup , Gala Andre Briosa e , Pope Michael , Pedersen Michala , Rajappan Kim , Ginks Matthew , Bashir Yaver , J Ross Hunter , Betts Tim
Published: March 2022

Introduction. When using Lesion Size index (LSI) to guide
catheter ablation, it is unclear what combination of power, contact
force and time would be preferable to use and what LSI target value to
aim for. This study aimed at identifying desirable ablation settings and
LSI targets by using tissue impedance drop as indicator of lesion
formation. Methods. Consecutive patients, undergoing their
first left atrial (LA) catheter ablation for atrial fibrillation, with
RF powers of 20, 30 and 40 W were enrolled. Tissue impedance, contact
force (CF), Force Time Integral (FTI) and LSI values were continuously
recorded during ablation and sampled at 100 Hz. Mean CF and Contact
Force Variability (CFV) were calculated for every lesion. The effect of
RF power, ablation time, CF and CFV on impedance drop and LSI were
assessed. Results. A total of 3258 lesions were included in the
analysis. For any target LSI value, use of higher RF powers translated
into progressively higher impedance drops. The impact of lower CF and
higher CFV on impedance drop was more relevant when using lower powers.
Target LSI values corresponding to maximum impedance drop were
identified depending on RF power, mean CF and CFV used.
Conclusions. Even in the context of an LSI-guided ablation
strategy, use of lower or higher powers might lead to different lesion
sizes. Different LSI targets might be needed depending on the
combination of RF power, CF and CFV used for ablation. Incorporating
indicators of catheter stability, like CFV, in the LSI formula could
improve the predictive value of LSI for lesion size. Studies with
clinical outcomes are required to confirm the clinical relevance of
these findings.
Autologous recovery with chromosomal abnormalities after unrelated umbilical cord blood transplantation with myeloablative conditioning in a case of pediatric acute lymphoblastic leukemia
Authors: Uchihara Yoshinori , Kato Itaru , Hanaki Ryo , Saida Satoshi , Iwamoto Shotaro , Umeda Katsutsugu , Hiramatsu Hidefumi , Adachi Souichi , Takita Junko
Published: March 2022

Detailed case reports of autologous recovery of hematopoiesis after
hematopoietic stem cell transplantation with myeloablative conditioning
(MAC) are scarce. We present a rare case of a 3-year-old male with
relapsed KMT2A-rearranged acute lymphoblastic leukemia (ALL) who
experienced autologous recovery following secondary engraftment failure
after cord blood transplantation (CBT) with MAC. Similar to previous
reports, we detected unusual chromosomal abnormalities, which differed
at each bone marrow examination. He remains alive without relapse of ALL
12 months after CBT. As the rate of recurrence or late occurrence of
secondary malignant neoplasm remains unclear, careful follow-up is
required, especially in pediatric patients.
Treatment Strategy for Inoperable Von Hippel-Lindau-related Phaeochromocytoma： a case report and literature review
Authors: Shen Chuyu , Lv Xiaomei , Chen Jianchong , Guo Ying , Zhang Shaoling
Published: March 2022

Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine
tumors. Some advanced PPGLs are inoperable. Treatment strategies for
inoperable PPGLs should be discussed case by case under the coordination
of multidisciplinary team. Target organ management is crucial in
improving life quality and prognosis.
Multi-dimensional Besicovitch almost periodic type functions and applications
Authors: Kostic Marko
Published: March 2022

In this paper, we analyze multi-dimensional Besicovitch almost periodic
type functions. We clarify the main structural properties for the
introduced classes of Besicovitch almost periodic type functions,
explore the notion of Besicovitch-Doss almost periodicity in the
multi-dimensional setting, and provide some applications of our results
to the abstract Volterra integro-differential equations and the partial
differential equations.
S-asymptotically w-periodic mild solutions for non-instantaneous impulsive integro-differential equations with state-dependent delay
Authors: Wang Yinuo , Li Chuandong , Deng Hao , Wu Hangjun
Published: March 2022

A kind of nonlinear non-instantaneous impulsive equation with
state-dependent delay is studied here. By ultilizing suitable fixed
point theorem and the theory of semigroup in Banach space, the
uniqueness and existence results of S-asymptotically w-periodic mild
solutions are obtained, respectively. In the end, two examples are
presented to demonstrate the validity of the obtained results.
Solitary metastatic ovarian adenocarcinoma with gastrointestinal origin presenting as gigantic bilateral ovarian masses
Authors: tafti seyed mohsen ahmadi , behboudi behnam , nili fatemeh , hadizadeh Alireza
Published: March 2022

Metastatic ovarian cancers could originate from the gastrointestinal
tract, and the origin is diagnosed with pathologic and
immunohistochemistry evaluation. This case was a woman who was presented
with bilateral abdominal masses which were adenocarcinomas originating
from GIT. A mass was found in colonoscopy and total colectomy was
performed.
Provoked deep vein thrombosis and saddle pulmonary embolism in a pediatric patient with multiple genetic risk factors for venous thromboembolism
Authors: Hofstee Karina , Sartain Sarah , Shapiro Mary
Published: March 2022

Heterozygous mutations in Factor V Leiden (FVL) or prothrombin G20210A
(PT-G20210A) are relatively common; the presence of
double-heterozygosity for these mutations is rare but may be as high as
5% in patients with deep vein thrombosis (DVT). Antiphospholipid
syndrome (APS) is a rare autoimmune disorder and commonly presents in
adolescents and young adults. This report describes the diagnosis,
treatment, and outcome for acute presentation of extensive lower
extremity DVT and saddle pulmonary embolism (PE) in a previously healthy
17-year-old male found to have multiple genetic risk factors including
double-heterozygosity for FVL/PT-G20210A and concurrent APS, which is
rare and not well-described.
Local RBF-FD and LRBF-DQM Based Meshfree Algorithms for Computational Modeling of Wave Models
Authors: Verma Pooja , Jiwari Ram , Kumar Manoj , . Poonam
Published: March 2022

This article offered two meshfree algorithms namely local RBF-FD
(LRBF-FD) approximation and local RBF-DQ method (LRBF-DQM) to simulate
the 2nd order hyperbolic wave models (HVMs). In the evolvement of the
first algorithm, time derivative is discretized by forward FD scheme and
Crank-Nicolson scheme is used for rest of the terms. After that, LRBF-FD
approximation is used for spatial discretization and quasi-linearization
process for linearization the problem. Finally, the obtained linear
system is solved by LU decomposition method. In the development of
second algorithm, semi-discretization in space is done via LRBF-DQM and
then an explicit RK4 is used for fully discretization in time. Stability
analysis of the second algorithm has been discussed. For simulation
purpose, some HVMs namely telegraph (TG), Klein-Gordon (KG), Sine-Gordon
(SG), Vander Pol type (VPT) and Dissipative (DP) wave models are
pondered to instigate the chastity and competence of the developed
algorithms.
Graves' dermopathy during Covid 19 pandemic
Authors: Pasquali Daniela , Fraia Rosa Di , Selvaggio Lucia Digitale , Allosso Francesca , Accardo Giacomo
Published: March 2022

A 27 year old man with an history of persistent hyperthyroidism, had
been referred to surgeon for total thyroidectomy, but the procedure was
delayed during the COVID-19 pandemic. He developed a nonpitting oedema
on the pretibial region of both legs leading to diagnosis of thyroid
dermopathy.
Tension-free trans-obturator tape enhanced thermodynamic efficacy of the bladder in stress urinary incontinence patients: a retrograde observational study
Authors: LAU HUI-HSUAN , Lai Cheng-Yuan , Peng Hsien-Yu , Hsieh Ming-Chun , Su Tsung-Hsien , Lee Jie-Jen , Lin Tzer-Bin
Published: March 2022

Objective In contrast to the well-recognized benefit of trans-obturator
tape (TOT) to urine continence, if the TOT-enhanced urethra resistance
results in modified voiding functions in stress urinary incontinence
(SUI) patients is not adequately investigated. Design and setting
Urodynamic investigations were retrograde analyzed in a tertiary
referral hospital. Population A total of 26 female SUI patients Methods
The area enclosed by the loop trajectory (Apv) in a pressure-volume
analysis (PVA) which represent the work performed in each voiding cycle
was retrospectively analyzed Main outcome measures The Apv of female SUI
patients before and after the TOT were analyzed. Results When compared
with the pre-operative control, the Apv was significantly increased
post-operatively. The TOT-enhanced Apv was accompanied by increments in
the mean urethra resistance (Rv) and mean voiding pressure (Pv) but
unaffected voided volume (Vv) and voiding time (Tv). Moreover, the
TOT-induced Apv increase (ΔApv) displayed moderate correlations with the
changes in Rv and Pv (ΔRv and ΔPv, respectively) but no correlation with
the changes in Vv or Tv (ΔVv and ΔTv, respectively). Notably, the
TOT-induced ΔRv displayed a strong correlation with the ΔPv.
Conclusions: The thermodynamic efficacy of the bladder was enhanced
after the TOT; that could be attributed to that bladder develops an
elevated pressure gradient in response to the TOT-enhanced outlet
resistance during urine emission. Keywords: mid-urethra sling,
trans-obturator tape, stress urinary incontinence, urethra resistance,
thermodynamics, pressure-volume analysis Tweetable abstract The bladder
developed an elevated pressure gradient to the TOT-enhanced outlet
resistance; and herein enhanced the voiding efficacy.
Pulmonary dysfunction in childhood Hodgkin lymphoma survivors: An observational study
Authors: Mude Praneetha , Seth Rachna , Meena Jagdish , Gupta Aditya , Kabra Sushil , Gupta Sumita , Dwivedi SN , Kandasamy Devasenathepathy
Published: March 2022

Background: Childhood cancer survivors are 8.8 times more likely to die
of pulmonary causes when compared to general population: an aspect of
concern. Pulmonary dysfunction is the third leading cause of non
recurrence related cause of death among Hodgkin lymphoma survivors.
Methods: A cross section study on Hodgkin lymphoma survivors in complete
remission, who completed treatment within last 5 years was done. All
children were subjected to detail history including drugs, past history
of respiratory illnesses, physical and respiratory system examination
followed by spirometry and three minute step test under supervision.
Pulmonary dysfunction was determined as presence of obstructive,
restrictive or mixed pattern on spirometry or abnormality in three
minute step test. Subclinical pulmonary dysfunction was determined as
patients who were clinically asymptomatic but had pulmonary dysfunction
Results: A total of 60 children were enrolled (Mean age of 11.3 years
and 53 were boys) Abnormal pulmonary function tests were documented in
11 (18.3%) of HL survivors at a median time of 2 years (IQR 1,3) from
treatment completion. Restrictive pattern was documented in 10 (16.67%)
and obstructive pattern in only one patient (1.67%), mostly mild in
severity. Older age at start of chemotherapy and radiotherapy and past
history of respiratory illness were found to be significantly associated
with pulmonary dysfunction. Conclusion: Majority of Hodgkin lymphoma
survivors had subclinical pulmonary dysfunction at median follow up of 2
years from treatment completion. Hodgkin lymphoma survivors require long
term follow up for timely detection of pulmonary dysfunction and improve
quality of life.
Polyoxometalates encapsulated into hollow periodic mesoporous organosilica for desulfurization
Authors: GAO YAN , yan miao , ZHAO Jianshe
Published: March 2022

In this work, the highly active polyoxometalate (PMo2W2) with Venturello
structure was effectively encapsulated into hollow periodic mesoporous
organosilica (HPMOS) to form hollow nanoreactor PMo2W2@HPMOS, where
central cavity and mesoporous shell both provide a stable place to react
with organic sulfides. In addition, the ordered pores in the shell
facilitate mass transfer, that is, sulfide molecules can freely move in
and out of the nanoreactor. Desulfurization test results show that
hollow nanoreactor PMo2W2@HPMOS can almost remove four sulfides
simultaneously from diesel in 2 h under mild conditions. Besides, the
excellent reusability of the nanoreactor also indicates that the
confined effect of mesoporous shell contributes to solidify the active
component.
Transposition Physiology in the Setting of Concordant Ventriculo-arterial Connections
Authors: Chowdhury Ujjwal , Anderson Robert , Spicer Diane E. , George Niwin , Sankhyan Lakshmi , Pandey Niraj , Goja Shikha , Chandhirasekar Balaji
Published: March 2022

Background and Aim: To review the anatomical details,
diagnostic challenges, associated cardiovascular anomalies, and
techniques and outcomes of management, including re-interventions, for
the rare instances of transposition physiology with concordant
ventriculo-arterial connections. Methods: We reviewed clinical
and necropsy studies on diagnosis and surgical treatment of individuals
with transposition physiology and concordant ventriculo-arterial
connections, analyzing also individuals with comparable flow patterns in
the setting of isomerism. Results: Among reported cases, just
over two-thirds were diagnosed during surgery, after initial palliation,
or after necropsy. Of the patients, four-fifths presented in infancy
with either cyanosis or congestive cardiac failure, with complex
associated cardiac malformations. Nearly half had ventricular septal
defects, and one-fifth had abnormalities of the tricuspid valve,
including hypoplasia of the morphologically right ventricle. A small
minority had common atrioventricular junctions We included cases
reported with isomerism when the flow patterns were comparable, although
the atrioventricular connections are mixed in this setting. Management
mostly involved construction of intraatrial baffles, along with
correction of coexisting anomalies, either together or multi-staged.
Overall mortality was 25%, with one-fifth of patients requiring
pacemakers for surgically-induced heart block. The majority of survivors
were in good functional state. Conclusions: The flow patterns
produced by discordant atrioventricular and concordant
ventriculo-arterial connections remain an important, albeit rare,
indication for atrial redirection. The procedure recruits the
morphologically left ventricle in the systemic circuit, producing good
long-term functional results. The approach can also be used for those
with isomeric atrial appendages and comparable hemodynamic circuits.
Stability and Hopf Bifurcation of a Kaldor-Kalecki Business Cycle with Double Delays
Authors: Li Bingbing , Liao Maoxin , Xu Changjin , Li Weinan
Published: March 2022

In this paper, a Kaldor-Kalecki business cycle model with double delays
is considered. By using the stability theory and bifurcation theory of
functional differential equations, we obtain the local stability and the
conditions of Hopf bifurcation of the system at the equilibrium point.
We focus on the impact of consumption delay and investment delay on
stability, respectively. Finally, the results of theoretical analysis
are verified by some numerical simulations.
Dermatomal and Solitary Plaque-type Psoriasis: Report of Two Unusual Cases
Authors: Fatemi Farahnaz , mohaghegh fatemeh , jelvan minoo , Rezaei Mina , tabatabaei elham tavousi
Published: March 2022

Psoriasis is a chronic inflammatory skin disease with unknown etiology
and a wide spectrum of clinical presentations. We report the first case
of dermatomal psoriasis in a 62-year-old patient in addition to an
unusual presentation of psoriasis as a solitary plaque on the ear of a
38-year-old patient.
PGAP6 drives chemotherapy resistance in Ewing sarcoma
Authors: Yu Yonghua , Zhang Lili , Zhang Yong
Published: March 2022

Abstract Background: The prognosis of recurrent and metastatic Ewing
sarcoma (EWS) is extremely poor and the problem of drug resistance is
significant; thus, it is extremely important to identify the mechanisms
underlying chemotherapy resistance. This study aimed to explore the
genes associated with chemotherapy resistance in EWS. Procedure: Gene
expression profile data of GSE12102 and GSE63155were downloaded from GEO
to screen for differentially expressed genes (DEGs). GO functional
annotation analysis was performed on common DEGs. Twenty-one patients
were divided into good response (tumor necrosis rate ≥90%) (n=4) and
poor response (tumor necrosis rate <90%) (n=17) groups to
chemotherapy. Formalin-fixed paraffin-embedded (FFPE) tissues of 21
patients after chemotherapy and 5 patients who are in poor response
group before chemotherapy were collected. Real-Time Quantitative Reverse
Transcription PCR(qRT-PCR) was used to verify gene expression
differences.. The relationship between prognosis and gene expression
level verified by GSE17679 Results: The PGAP6 expression level after
chemotherapy in the poor response group (2.78 ± 2.36) was higher than
that in the good response group (1.16 ± 0.65) (P = 0.024). Expression of
PGAP6 after chemotherapy (16.70 ± 13.78) was higher than that before
chemotherapy (1.16 ± 0.62; P = 0.071). Verified by external datasets,
the expression level of PGAP6 was related to prognosis. Conclusions:
PGAP6 drives EWS chemoresistance and may be associated with acquired
resistance. The expression levels of PGAP6 correlated with EWS
prognosis. PGAP6 can be used as a new target for reversing chemotherapy
resistance of EWS. KEYWORDS: Ewing sarcoma; chemotherapy; drug
resistance; PGAP6; TMEM8A
Non-bacterial thrombotic endocarditis with atypical presentation as overt congestive heart failure
Authors: Andò Giuseppe , Restelli Davide , Trio Olimpia , Poleggi Cristina , Piccione Maurizio Cusmà , Manganaro Roberta , Certo Giuseppe , Zito Concetta
Published: March 2022

Introduction. Non-Bacterial Thrombotic Endocarditis (NBTE) is a form of
endocarditis associated with malignancy or autoimmune disorders.
Diagnosis remains a challenge as patients are often asymptomatic up to
embolic events or, rarely, valve dysfunction. We report a case of NBTE
with uncommon clinical presentation and identified with multimodal
echocardiography. Case presentation. An 82-year-old man presented to our
outpatient clinic reporting dyspnea. Past medical history included
hypertension, diabetes, kidney disease, and unprovoked deep vein
thrombosis. On physical examination, he was apyretic, mildly hypotensive
and hypoxemic, had a systolic murmur and lower limbs edema.
Transthoracic echocardiography revealed severe mitral regurgitation due
to verrucous thickening of the free margin of both leaflets, increased
pulmonary pressure, and dilated inferior vena cava. Multiple blood
cultures were negative. Transesophageal echocardiography confirmed
“thrombotic” thickening of mitral leaflets. Nuclear investigations
were highly suggestive of multi-metastatic pulmonary cancer. We did not
further proceed in the diagnostic workup and prescribed palliative care.
Discussion. Lesions seen on echocardiography were suggestive of NBTE:
they involved both sides of mitral leaflets, close to the edges, had
irregular shape and echo-density, a broad base, and no independent
motion. Criteria for infective endocarditis were not met and the final
diagnosis was paraneoplastic NBTE due to underlying lung cancer. We
remark the lack of definitive recommendations about treatment of NBTE
and the only role of anticoagulation to prevent systemic embolism.
Conclusions. We report a case of NBTE presenting with atypical symptoms
and likely related to the prothrombotic state induced by underlying lung
cancer. Provided the unconclusive microbiological tests, multimodal
imaging played a crucial role for the final diagnosis.
Ant assemblage turnover is greater horizontally than vertically in the world's tallest tropical forest
Authors: Xing Shuang , Hood Amelia , Dial Roman , Fayle Tom
Published: March 2022

Abiotic and biotic factors structure species assembly in ecosystems both
horizontally and vertically. However, the way community composition
changes along comparable horizontal and vertical distances in complex
three-dimensional habitats, and the factors driving these patterns,
remain poorly understood. By sampling ant assemblages at comparable
vertical and horizontal spatial scales in a tropical rain forest, we
compared observed patterns with those predicted according to
environmental filtering by microclimate and microhabitat structure. We
found that although dissimilarity between ant assemblages increased with
vertical distance, the dissimilarity was higher horizontally but was
independent of distance. The pronounced horizontal and vertical
structuring of ant assemblages across short distances is likely
explained by a combination of microclimate and microhabitat
connectivity. Our results demonstrate the importance of considering
three-dimensional spatial variation in local assemblages and reveal how
highly diverse communities can be supported by complex habitats.
Variable chemical process and radiative nonlinear impact on MHD Cross nanofluid: An approach towards controlling the global warming
Authors: Darvesh Adil , Altamirano Gilder Cieza , Sánchez-Chero Manuel , Zamora William Rolando Miranda , Campos Franklin Guerrero
Published: March 2022

Solar energy is basic source of renewable energy, and it is being used
for controlling the global pollutions/warming. As cross nanofluid is
very useful for upgrading the solar energy systems efficiency so it is
engaged for cooling the solar devices. In this paper for analysis of
global warming heat equation is modeled by incorporating the nonlinear
thermal radiation by using the exponentially extendable surface, because
it keeps major role related to solar energy absorption of nanofluid.
Furthermore, the mathematical modeling of cross nanofluid involving
magnetic effect and diffusion is discussed by using the fact of chemical
reaction. Chemical reaction finds astonishing applications regarding
pollution studies, chemical processing equipment, polymer production. As
a result of this study, it is noticed that more magnetized the
conducting fluid controls the motion of fluids for both case of shear
thinning and shear thickening. Brownian motion parameter Nb tells the
rate the random motion of nanoparticle. Increased Nb temperature is also
increases due to these random movement of nanoparticles. That is the
reason when pollutant nanoparticles spreading in air as a result global
warming increase.
AMYOTROPHIC LATERAL SCLEROSIS PATIENTS IN OTORHINOLARYNGOLOGY: A RETROSPECTIVE STUDY
Authors: Rautiola Jesper , Laaksovirta Hannu , Geneid Ahmed , Ilmarinen Taru , Pietarinen Petra , Kinnari Teemu
Published: March 2022

Abstract OBJECTIVES Given its rarity and the lack of clear clinical
markers, amyotrophic lateral sclerosis (ALS) remains a diagnostic
challenge. Since bulbar-onset ALS (buALS) presents with impaired speech
or swallowing, patients are often primarily referred to an
otolaryngologist (ORL) or phoniatrician. We analyzed the role of such
specialists in ALS diagnostics and treatment. PARTICIPANTS We reviewed
data for all 327 patients treated for ALS through the Hospital District
of Helsinki and Uusimaa (HUS) between 2010 and 2014, focusing
specifically on 110 (34%) patients presenting with bulbar nerve onset
(buALS). MAIN OUTCOME MEASURES The presenting symptoms, referral to
specialized care, and to a neurology clinic were assessed. Indications
and findings from swallowing studies were reviewed as well as the
incidence of percutaneous endoscopic gastrostomy (PEG) and tracheostomy.
RESULTS Among the 110 patients with buALS, 64 (58%) were primarily
referred to a neurologist, 28 (25%) to an ORL, and 5 (5%) to a
phoniatrician. The most common presenting symptom was dysarthria in 89
patients, (81%), followed by dysphagia in 26 (24%). In most cases, an
ORL or phoniatrician suspected a neuromuscular disease; however, in 8
(24%) cases, the neurological etiology of symptoms was missed. Overall,
49 (45%) patients underwent a swallowing study and 86 (78%) patients
underwent PEG placement. CONCLUSIONS Among buALS patients, 30%
initially consulted an ORL or phoniatrician and 45% underwent a
swallowing study. Based on our results, swallowing studies rarely lead
to immediate PEG placement. An initial visit to other specialists had no
impact on diagnostic delays or survival. Five keypoints Amyotrophic
lateral sclerosis (or ALS) Motor neuron disease Dysphagia Fiberoptic
Endoscopic Examination of Swallowing (or FEES) Percutaneous Endoscopic
Gastrostomy (or PEG) Level of Evidence: 3
Title : Recurrent syncope late after permanent pacemaker implantation - What is the mechanism?
Authors: Bera Debabrata , Joshi Radhey Shyam , Bauri Mrityunjay , Gupta Anunay
Published: March 2022

A 68-yr-old lady underwent a VVI pacemaker implantation 10 years back
for infra-hisian complete heart block. Now she presents with 3 episodes
of syncope within the last 2 months. Detailed neurological evaluation
and pacemaker checkup was initially unremarkable. Real time electrograms
during device interrogation were suspicious of lead noise resulting in
oversensing. She became alright when the pacing mode was made VOO
immediately. After discussion with patient relatives she underwent
ventricular lead replacement and upgradation to a dual chamber
pacemaker. However, in the immediate post-operative period she became
unresponsive requiring immediate resuscitation. Monitor suggested short
runs of polymorphic VT which was reproducibly suppressed with higher
rate obligatory pacing @ 110 bpm. The runs of VT resurfaced immediately
as the rate was lower than 90. She was managed by overdrive pacing at a
lower rate of 110 bpm. Over the next 2 months the lower rate was brought
down to 70 bpm in a stepwise manner. A retrospective analysis of her
initial stored device electrogram suggested that it was all PMVT and no
noise at all. The cause of her polymorphic VT is not clear. Relative
hypomagnesemia, late presenting long QT syndrome and long term VVI
pacing in isolation or combination remain the probable offender. She is
presently doing well on oral propranolol.
Identification of a plant-derived small molecule with potent anti-obesity and anti-diabetic activities in type 2 diabetic mice
Authors: Wang yao , Luo Jing , wang Aiping , Wu Yajun , Wang Aihua , Alkhalidy Hana , Helm Richard , Ma Hongguang , Zhang Yan , Rainville Jennifer , Hodes Georgia , Xu Bin , Liu Dongmin
Published: March 2022

Insulin resistance and progressive decline in functional β-cell mass are
two key factors for developing T2D, which is largely driven by
overweight and obesity, a significant obstacle for effective metabolic
control in many patients with T2D. Thus, agents that simultaneously
ameliorate obesity and promote insulin sensitivity and β-cell function
could be more effective for treating T2D. Here, we report that elenolic
acid (EA), a small molecule, is such a dual-action agent. Oral
administration of EA restored glucose homeostasis and other metabolic
disorders in diet-induced obese mice, which were associated with
increased circulating GLP-1, PYY, and GIP concentrations. EA slowed
gastric emptying, downregulated hypothalamic agouti-related peptide, and
reduced food intake and obesity in obese mice. EA also exerted potent
anti-hyperglycemic effect in db/db mice that was comparable to that of
liraglutide but greater than that of metformin, and it was more
effective in promoting weight loss relative to these two drugs.
Mechanistically, EA directly stimulated GLP-1 and PYY secretion from
L-cells, and its induction of GLP-1 release is mediated via
Gαq/phospholipase C-mediated pathway. EA also directly suppresses
glucose production in liver cells. These results suggest that EA is a
novel, dual-action agent for developing drug to treat both T2D and
obesity.
A systematic review of the feasibility and safety of day case nasal and/or palatopharyngeal surgery in patients with obstructive sleep apnoea
Authors: Tan E Tian , Leong Wei , Edafe Ovie , Mirza Showkat
Published: March 2022

Introduction Recent guidelines suggest obstructive sleep apnoea (OSA) is
not an absolute contraindication for same day discharge following
surgery. The aim of this systematic review was to examine the
feasibility and safety of day case nasal and/or palatopharyngeal surgery
in patients with OSA. Methods We performed a systematic search of
PubMed, EMBASE and the Cochrane library. Quality assessment of included
studies was done. The protocol of this systematic review was registered
with PROSPERO (CRD42021273451). Results A total of 1836 patients from
ten observational studies were included. There were 268 (15.4%) nasal
surgeries, 738 palatopharyngeal surgeries (42.4%) and 735 (42.2%)
combined nasal and palatopharyngeal surgery. The majority of patients
had moderate to severe OSA. A total of 860 patients (49.8%) were
successfully discharged as day cases. There were no standard criteria
for daycase surgery. Post-anaesthetic respiratory events were reported
in 86/1750 (4.9%) patients. Oxygen desaturation was the most common
respiratory event (83.7%, n = 72). There was no mortality reported.
Conclusion Current data suggests day surgery is feasible in carefully
selected patients with OSA undergoing nasal and/or palatopharyngeal
surgery. Further well-designed prospective studies with an emphasis on
the systematic assessment of complications are required to establish
safety and daycase criteria.
ACUTE LEFT ANTERIOR DESCENDING ARTERY THROMBUS WITH IN 2 HOURS OF COVID VACCINATION: CASE REPORT
Authors: KUMAR LALIT , PATHAK VIJAY
Published: March 2022

Covid 19 pandemic has shocked the world over the last 2 years.
Thankfully with the use of covid mass vaccination life is returning back
to normal . Here we describe a case of suspected acute ST elevation
anterior wall myocardial infarction and LAD artery thrombus in two hours
of vaccination
A new general theory of Island Biogeography
Authors: Beaugrand Gregory , Kléparski Loïck , Luczak Christophe , Goberville Eric , Kirby Richard
Published: March 2022

The Equilibrium Theory of Island Biogeography (ETIB) is a widely applied
dynamic theory proposed to explain why islands have coherent differences
in species richness. The development of the ETIB was temporarily
challenged by the alternative static Theory of Ecological Impoverishment
(TEI), which suggests that the number of species on an island is
determined by its number of niches or habitats. With no clear evidence
relating species richness to the number of niches, the TEI was almost
abandoned in favour of the ETIB. Here, we show that the number of
climatic niches on islands is an important predictor of the species
richness of plants, herpetofauna and land birds, and we propose a new
model called the General Theory of Island Biogeography (GTIB) that
merges the ETIB and TEI theories. When we test our GTIB for resident
land birds in Krakatau Islands it reveals a good correspondence with
observed species richness, immigration and extinction rates.