bluuebunny/crossref_metadata_2025 huggingface dataset:
890-P: Ultraselective DYRK1A/B Inhibitors Mediated ß-Cell Proliferation and Insulin Production In Vitro and In Vivo
Authors: KUMAR MITTAPALLI GOPI , MAK CHI-CHING , BOSSARD CARINE , REDDY VAKITI RAMKRISHNA , CREGER EMILY , GUTIERREZ ERIK , HORSLEY ERICH A. , SWEARINGEN CHRISTOPHER , HILL JOHN S.
Published: June 2024

Introduction and Objective: Non-selective DYRK1A/B inhibitors have been reported to stimulate pancreatic β-cell proliferation and insulin production. However off-target kinase inhibition remains a concern. Development of 2 novel highly selective DYRK1A/B inhibitors and results of in vitro and in vivo studies showing their ability to stimulate β-cell proliferation, mediate production of insulin and lowering of HbA1c levels in vivo are reported.

Methods: SM15238 and SM15268 (DMSO and harmine as -ve & +ve controls) were investigated in the 3D InSight™ Human Islet Microtissue (spheroids) system to assess β-cell proliferation and function. In vivo studies were conducted in 5-week-old male db/db mice receiving daily oral dosing (35 days) of either molecule or vehicle for 5 weeks (n=8/group), measuring body weight (BW), fasted and non-fasted glucose (GLU), HbA1c levels, OGTT, CMP18, and histological analysis of pancreatic tissue.

Results: Spheroids treated for 4 days with SM15238 and SM15268 (1 or 5μM) demonstrated increased β-cell proliferation compared to DMSO, a significant increase in stimulated insulin secretion at 1μM SM15238 and a similar trend at both concentrations of SM15268 (Dunnett’s 1-way ANOVA) compared to controls. Oral dosing of both molecules at 45 mg/kg once daily in db/db mice resulted in sustained increased circulating 4-hr fasted insulin levels. Mice treated with SM15268 had significantly reduced non-fasted and 4-hr fasted GLU levels and those treated with SM15238 significantly reduced GLU during OGTT. Dosing with both molecules resulted in decreases in HbA1c levels after 21 days. Histological analysis showed β-cell proliferation but no significant increase in α-cells.

Conclusions: In this early proof of concept study, selective small molecule inhibitors of DYRK1A/B mediated β-cell proliferation and induced positive changes in in vitro and in vivo hyperglycemic settings. Further toxicology and dose optimization studies are planned.

Disclosure

G. Mittapalli: Employee; Biosplice Therapeutics. C. Mak: Employee; Biosplice Therapeutics, Inc. C. Bossard: Employee; Biosplice Therapeutics. R. Vakiti: Employee; Biosplice Therapeutics. E. Creger: Employee; Biosplice Therapeutics. E. Gutierrez: Employee; Biosplice Therapeutics. E.A. Horsley: None. C. Swearingen: Employee; Biosplice Therapeutics. J.S. Hill: Stock/Shareholder; AbbVie Inc., Amgen Inc., Pfizer Inc. Employee; Biosplice Therapeutics.
892-P: Potential for New Oral Insulin Sensitizers in Combination with GLP-1 Agonists
Authors: COLCA JERRY R.
Published: June 2024

MSDC-0602K (azemiglitazone) is a second-generation insulin sensitizer that was designed based on the knowledge of the activity of active metabolites of the first-generation insulin sensitizer pioglitazone. This molecule was purposely designed not to bind to PPAR transcription factors but to maintain the interaction with the mitochondrial target of pioglitazone and its metabolites, namely the mitochondrial pyruvate carrier. A one-year dose-escalating phase 2b clinical trial in subjects with biopsy-proven NASH with and without diabetes was conducted from 2016-2019. This study demonstrated similar insulin sensitizing pharmacology as pioglitazone, but without dose-liming issues at up to two times the exposures that occur with the highest approved dose of pioglitazone (45 mg). Here we have looked specifically at the 23 subjects with NASH (MASH) and type 2 diabetes who had been enrolled in the trial while on a stable dose of a GLP1 agonist (11 liraglutide, 8 dulaglutide, and 4 exenatide). A further analysis of this subset showed that any dose of azemiglitazone was able to further lower fasting glucose, insulin and liver enzymes. On average there was a further decrease in HbA1 by 0.5% (from an average baseline of 7.2%) with several subjects showing more than a 2% decrease. Of particular interest with respect to the hepatic pathology, 5 of the 19 subjects who had been on both azemiglitazone and a GLP1 agonist had a reduction in the liver fibrosis scores in the post-treatment liver biopsies. GLP1 agonists are particularly useful in producing weight loss. Some subjects who had been on a GLP1 continued to lose weight while others did not. Given the major effects of his pharmacology to improve insulin sensitivity Iin skeletal muscle and based on some existing precedent with high dose pioglitazone, maintenance of lean mass could be a component of the overall pharmacology achieved with oral metabolic modulators.

Disclosure

J.R. Colca: Stock/Shareholder; Cirius Therapeutics, Inc.
899-P: Combinations of the Mitochondrial Protonophore TLC-6740 and/or the ACC2 Inhibitor TLC-3595 Provide Additive Glycemic Benefits to Semaglutide (SEMA) in db/db Mice
Authors: VIJAYAKUMAR ARCHANA , SRODA NATALIE , MURAKAMI EISUKE , WENG STEVE , MYERS ROBERT P. , SUBRAMANIAN MANI , SHULMAN GERALD I.
Published: June 2024

Background: TLC-6740, a liver-targeted mitochondrial uncoupler, and TLC-3595, a selective ACC2 inhibitor, are in development for obesity and diabetes. By enhancing substrate oxidation, 6740 and 3595 have complementary mechanisms to GLP-1R agonists. Here, we assessed effects of 6740, 3595, and SEMA monotherapy (mono) and combinations (combos) in db/db mice.

Methods: Male db/db mice (fasting glucose, FG>180mg/dL) were treated for 4 wk with vehicle (Veh), 6740, 3595, or SEMA mono or dual/triple combos. At 3 wk, an oral glucose tolerance test (oGTT) was performed and incremental AUC (iAUC) of glucose was calculated normalizing for glycemia before glucose bolus.

Results: FG was lower in all groups vs Veh with the greatest reductions in 6740+3595, 6740+SEMA, and 6740+3595+SEMA combos (-42 to -56%) (Fig). While HbA1c was lower with all monos vs Veh (-0.6 to -1.0%), combos had the greatest effect (-1.4 to -1.7%). Food intake was lower in all SEMA groups, but only SEMA+3595 caused weight loss (-11%). oGTT iAUC was reduced vs Veh with only ‘6740 mono (-26%) and SEMA combos with 6740 (-40%), 3595 (-31%), and 6740+3595 (-41%).

Conclusions: In db/db mice, 6740 improved glucose tolerance, FG, and HbA1c similarly to SEMA. Addition of 6740 and/or 3595 to SEMA improved glycemic parameters, supporting evaluation of combinations with GLP-1R agonists for diabetes.

Disclosure

A. Vijayakumar: Employee; OrsoBio, Inc. N. Sroda: Employee; OrsoBio, Inc. E. Murakami: Employee; OrsoBio, Inc. S. Weng: Employee; OrsoBio, Inc. R.P. Myers: Employee; OrsoBio, Inc. M. Subramanian: Board Member; OrsoBio, Inc. G.I. Shulman: None.
909-P: Impact of SGLT2 Inhibition on Glucosuria in HNF1A-MODY
Authors: MAAGENSEN HENRIK , JENSEN JOHANNE S. , OFFERSGAARD HØYERUP STINE , THUESEN ANNE CATHRINE B. , KROGH JESPER , ROSSING PETER , HANSEN TORBEN , KNOP FILIP K. , HAEDERSDAL SOFIE , VILSBØLL TINA
Published: June 2024

Introduction & Objective: Pathogenic variants in HNF1A cause maturity-onset diabetes of the young type 3 (HNF1A-MODY, MODY3) which is associated with relative hyper-glucosuria that has been attributed to lower expression of sodium-glucose cotransporter 2 (SGLT2) in HNF1A knockout mice; questioning SGLT2 as a relevant treatment target in these individuals.

Methods: In a randomized, double-blind, crossover study, persons with MODY3 and type 2 diabetes (T2D) underwent two three-step hyperglycemic clamps targeted at 10, 14, and 18 mmol/L (1h each) with and without acute SGLT2 inhibition (25 mg empagliflozin or placebo 2h before clamp).

Results: Participants characteristics: MODY3 (N = 11, 5 men; age (mean, SD) 49 ± 15 years; BMI 24.5 ± 3.9 kg/m2; HbA1c 6.7 ± 0.7%; eGFR 109 ± 14 mL/min/1.73 m2); T2D (n = 10, 8 men; age 63 ± 7 years; BMI 26.4 ± 3.5 kg/m2; HbA1c 6.7 ± 0.6%; eGFR 93 ± 12 mL/min/1.73 m2). In both groups, SGLT2 inhibition had robust effects on urinary glucose excretion, urine volume, infused glucose, and plasma glucose AUC (data in table). No significant differences between groups in the effects of SGLT2 inhibition were observed.

Conclusion: The similar effects of SGLT2 inhibition in persons with MODY3 and T2D observed here, point to SGLT2 inhibition as a relevant glucose-lowering treatment strategy in persons with MODY3 despite the potentially lower SGLT2 expression.

Disclosure

H. Maagensen: None. J.S. Jensen: None. S. Offersgaard Høyerup: None. A.B. Thuesen: None. J. Krogh: None. P. Rossing: Other Relationship; AstraZeneca, Bayer Inc., Boehringer-Ingelheim, Gilead Sciences, Inc., Novo Nordisk, Eli Lilly and Company, Novartis AG, Abbott Diagnostics. T. Hansen: None. F.K. Knop: Advisory Panel; AstraZeneca. Consultant; AstraZeneca. Speaker's Bureau; AstraZeneca. Advisory Panel; Boehringer-Ingelheim. Consultant; Boehringer-Ingelheim. Speaker's Bureau; Boehringer-Ingelheim. Advisory Panel; Eli Lilly and Company. Consultant; Eli Lilly and Company. Speaker's Bureau; Eli Lilly and Company. Stock/Shareholder; Eli Lilly and Company. Advisory Panel; Novo Nordisk A/S. Consultant; Novo Nordisk A/S. Employee; Novo Nordisk A/S. Research Support; Novo Nordisk A/S. Speaker's Bureau; Novo Nordisk A/S. Stock/Shareholder; Novo Nordisk A/S. Advisory Panel; Sanofi. Speaker's Bureau; Lundbeck. Advisory Panel; Zealand Pharma A/S. Consultant; Zealand Pharma A/S. Research Support; Zealand Pharma A/S. Speaker's Bureau; Zealand Pharma A/S. Stock/Shareholder; Zealand Pharma A/S. S. Haedersdal: None. T. Vilsbøll: Consultant; AstraZeneca. Advisory Panel; Boehringer-Ingelheim. Speaker's Bureau; Mundipharma. Advisory Panel; Novo Nordisk, Lilly Diabetes, Sanofi. Speaker's Bureau; Bayer Inc., Gilead Sciences, Inc. Advisory Panel; Sun Pharmaceutical Industries Ltd. Research Support; Lilly Diabetes.
917-P: Sotagliflozin vs. Empagliflozin or Placebo in Type 2 Diabetes on a DPP-4i +/- Metformin
Authors: PETERS ANNE L. , HARDIN MARQUETTE B. , CARROLL AMY K. , BANKS PHILLIP L. , ROSENSTOCK JULIO
Published: June 2024

Clinical trials (inTandem, SOLOIST-WHF, and SCORED) utilizing sotagliflozin (SOTA), a dual SGLT1 and SGLT2 inhibitor, have demonstrated glycemic improvements in patients with type 1 diabetes (T1D) and reduced heart failure-related hospitalizations and cardiovascular mortality in patients with type 2 diabetes (T2D). The purpose of this study was to evaluate the superiority of SOTA vs placebo and noninferiority of SOTA vs empagliflozin (EMPA), a selective SGLT2 inhibitor, on HbA1c reduction in individuals with T2D who had inadequate glycemic control on a DPP4i with or without metformin. This phase 3, double-blind, placebo- and active-control, parallel-group 26-week trial randomized 770 participants (mean HbA1c 8.2%, age 59.4 yrs, T2D duration 9.2 yrs, BMI 32.2 kg/m2) to receive SOTA 400 mg once daily, EMPA 25 mg once daily, or matching placebos. Changes in HbA1c, postprandial glucose (PPG), fasting plasma glucose (FPG), body weight, and systolic blood pressure (SBP) were assessed, as well as adverse events. SOTA was superior to placebo and noninferior to EMPA in reducing HbA1c. Additionally, SOTA was superior to placebo for other metabolic measurements. Percentage of patients with at least 1 hypoglycemic event, Levels 1 - 3 included, was 4.5% in the placebo group, 0.7% in the SOTA group, and 2.9% in the EMPA group. Other adverse events in the SOTA group aligned with expectations associated with SGLTi therapy.

Disclosure

A.L. Peters: Advisory Panel; Lilly Diabetes, Vertex Pharmaceuticals Incorporated, Medscape. Research Support; Abbott, Insulet Corporation. M.B. Hardin: Employee; Lexicon Pharmaceuticals, Inc. A.K. Carroll: Employee; Lexicon Pharmaceuticals, Inc. P.L. Banks: Employee; Lexicon Pharmaceuticals, Inc. J. Rosenstock: Research Support; Biomea Fusion, Inc. Other Relationship; Lilly Diabetes. Research Support; Merck & Co., Inc., Novartis Pharmaceuticals Corporation, Corcept Therapeutics. Other Relationship; Novo Nordisk. Research Support; Pfizer Inc. Other Relationship; Sanofi, Boehringer-Ingelheim. Research Support; Shionogi & Co., Ltd. Other Relationship; Structure Therapeutics, Inc. Advisory Panel; Terns Pharmaceuticals, Zealand Pharma A/S. Other Relationship; Applied Therapeutics, Hanmi Pharm. Co., Ltd., Oramed Pharmaceuticals. Advisory Panel; Scholar Rock.

Funding

Lexicon Pharmaceuticals, Inc.
934-P: Prescribing Patterns of Sodium–Glucose Cotransporter 2 Inhibitors in Patients with Heart Failure With or Without Type 2 Diabetes—A Continuing Review
Authors: WINTERS ASHLEY , LOPEZ MIGUEL , RAY GRETCHEN , ANDERSON JOE R.
Published: June 2024

Introduction: The prevalence of heart failure (HF) continues to increase and guidelines strongly recommend initiation of quadruple pharmacologic therapy including a sodium glucose co-transport 2 inhibitor (SGLT2i) for patients with all classifications of HF irrespective of type 2 diabetes (T2D). We previously conducted a study to characterize SGLT2i prescribing rates among patients with HF with or without T2D which demonstrated low utilization of SGLT2i at only 6.2%. A limitation of this study was that data was collected prior to the release of updated guidelines.

Objective & Methods: The objective of this study is to further describe prescribing patterns of SGLT2i in patients with HF. The University of New Mexico (UNM) Health Sciences Center IRB approved this retrospective, single-center, descriptive chart review. Individuals ≥ 18 years of age were included if they had a documented diagnosis of HF and had been seen in a UNM clinic defined as primary care, cardiology, heart failure, nephrology, or endocrinology from 12/2021 to 12/2023.

Results: A total of 395 patients were included in the study; 148 with HFrEF, 63 with HFmEF, and 184 with HFpEF. The mean age was 68 years; 44% were female; 54% were Hispanic, 66% had established atherosclerotic cardiovascular disease, and 47% had T2D. SGLT2i were prescribed in 28.1% of patients overall, 45.9% of patients with T2D, and 12.4% of patients without T2D. Predictors of SGLT2i prescribing include: T2D (OR= 4.6; 95% CI, 2.60-8.06), HFrEF (OR= 2.0, 95% CI 1.12-3.45), HF clinic visit (OR 1.8, 95% CI 1.01-3.14), visit with pharmacists having prescriptive authority (OR=4.6, 95% CI 1.96-10.88), and number of specialty provider visits (OR= 1.1, 95% CI 1.03-1.13).

Conclusion: SGLT2i utilization has increased since our previous study was conducted. However, SGLT2i continue to be underprescribed in patients with HF with or without T2D despite current guideline recommendations.

Disclosure

A. Winters: None. M. Lopez: None. G. Ray: None. J.R. Anderson: None.
964-P: Real-World Access to Diabetes Technology and Achieved HbA1c Levels in Type 1 Diabetes by Race and Ethnicity
Authors: ROBINSON SARAH , KLONOFF DAVID C. , DEAN LISA , SCOTT ALEXANDRA , LANE RASHON , KERR DAVID
Published: June 2024

Introduction: Recent research from specialist endocrine centers has highlighted racial disparities in access to care for individuals with type 1 diabetes (T1D). The aim of this study was to use real-world data to determine outcomes, including the use of technology, and achieved HbA1c levels for individuals with T1D in a large integrated healthcare delivery system in Northern California.

Methods: Using outpatient and hospital encounters from Sutter Health, individuals were included if most of the diabetic ICD codes between January 2021 and October 2023 were for T1D, and they had an insulin order. EHR extraction included physician orders, self-reported treatment, and self-reported race/ethnicity. One-way ANOVA and chi-squared test of independence were applied.

Results: A total of 7325 patients with T1D were identified. Minority groups were younger (Table). HbA1C values were significantly higher in Black and Hispanic populations compared to Whites. Excluding multiracial patients, continuous blood glucose monitors (CGM) and glucagon-like peptide 1 based therapies were also ordered at higher rates among minority groups. The use of hybrid closed-loop (HCL) systems is not significantly different among groups.

Conclusion: Although use of CGM occurred more frequently in minority groups, HbA1C values were higher compared to the White population. The use of HCL systems remails low across all groups.

Disclosure

S. Robinson: None. D.C. Klonoff: Consultant; Afon Technology Ltd, Better Therapeutics, Inc, Glucotrack, LIfecare, Nevro Corp., Novo Nordisk, Samsung, Thirdwayv Inc. L. Dean: None. A. Scott: None. R. Lane: None. D. Kerr: Advisory Panel; Abbott Diagnostics. Consultant; Sanofi, Better Therapeutics, Inc. Stock/Shareholder; Glooko, Inc.
975-P: Nocturnal Glucose Profile According to Predinner Insulin Injection Timing and Prandial and Basal Insulin Types in Type 1 Diabetes People Using Multiple Daily Injections—An Insulclock Connected Insulin Cap–Based Real-World Study
Authors: GOMEZ-PERALTA FERNANDO , VALLEDOR XOÁN , ABREU CRISTINA , FERNÁNDEZ-RUBIO ELSA , PUJANTE ALARCÓN PEDRO , AZRIEL SHARONA , CORCOY ROSA , RUIZ-VALDEPEÑAS LUIS
Published: June 2024

Introduction & Objective: To analyze the influence of timing and type of predinner rapid insulin and basal insulin on the nocturnal glucose profile.

Methods: Real-world, retrospective study in T1D people using multiple daily injections. Ten hours from dinner of paired continuous glucose monitoring data and insulin injections automatically tracked with the connected cap Insulclock® were analyzed. Meal events were identified using the ROC detection methodology. Glucometrics were evaluated according to insulin injection time around the dinner and short- and long-acting analog types.

Results: Nocturnal profiles (n=775, 49 subjects) were analyzed. Higher nocturnal glucose AUC over 180 mg/dL was observed in delayed injections (mean +SD; mg/dL x h): -45-15 min (n=136; 17.5%), 175.96 ±271.0; -15-0 min (n= 231; 29.8%), 164.0 ±237.1; 0+45 min (n= 408; 52.6%), 203.6 ±260.9, (p 0.049). Ultrarapid (FiAsp®) vs rapid insulin analogs use was associated with fewer events of glucose <70 mg/dl (7.1 vs 13.6; p 0.0051) and TBR70 (1.67 vs 4.58%; p 0.0036). Events of glucose <70 mg/dL and TBR70 adjusted by baseline glucose were similar by basal insulin type (glargine U300 vs degludec).

Conclusion: The timing and type of dinner prandial insulin affect the entire nocturnal glucose profile.

Disclosure

F. Gomez-Peralta: Advisory Panel; Abbott. Speaker's Bureau; Abbott. Advisory Panel; Eli Lilly and Company. Speaker's Bureau; Eli Lilly and Company. Advisory Panel; Insulcloud S.L. Speaker's Bureau; Medtronic. Advisory Panel; Novo Nordisk. Speaker's Bureau; Novo Nordisk. Advisory Panel; Sanofi. X. Valledor: Research Support; Insulcloud S.L. C. Abreu: None. E. Fernández-Rubio: Speaker's Bureau; Eli Lilly and Company, Medtronic, Novo Nordisk, Novalab. P. Pujante Alarcón: Speaker's Bureau; Dexcom, Inc., AstraZeneca, Novo Nordisk. S. Azriel: Speaker's Bureau; A. Menarini Diagnostics, Abbott, AstraZeneca, Boehringer-Ingelheim, Dexcom, Inc., Lilly Diabetes, Novartis Pharmaceuticals Corporation, Novo Nordisk Foundation, Sanofi. R. Corcoy: Other Relationship; Lilly Diabetes, Sanofi, Novo Nordisk, Roche Diabetes Care, Abbott Diagnostics, Dexcom, Inc., Menarini. Research Support; Ypsomed AG. Other Relationship; Medtronic. L. Ruiz-Valdepeñas: None.
992-P: Continuous Glucose Monitoring during Hospitalization in Patients with Total Pancreatectomy Reveals Significant Hyperglycemia
Authors: RAZA RIZVI SHAFAQ , BANERJEE AYAN , JEET KAUR RAVINDER , GUPTA SANDEEP , REID COREY , DESJARDINS DONNA , KENDRICK MICHAEL L. , TRUTY MARK , KUDVA YOGISH C.
Published: June 2024

Introduction and Objectives: To our knowledge, only a few studies assessed continuous glucose monitoring (CGM) metrics in total pancreatectomy (TP) without islet autotransplantation during hospitalization.

Methods: We completed blinded CGM (Dexcom G6 Pro) studies in 28 subjects who had TP at Mayo Clinic, Rochester in a non-ICU setting and compared 2 cohorts (CGM data < 30 days of TP vs. ≥ 30 days of TP). CGM glucose metrics were calculated as per ADA guidelines for hospitalized patients with diabetes mellitus (DM). CGM values were compared with point-of-care -testing glucose within 5 minutes.

Results: Baseline characteristics were 50% F, age 59.5 ± 8.2 yrs, BMI 26.7 ± 3.4 kg/m2, preexisting type 2 DM (Y/N=8/20) with mean duration of DM 7.9 ± 8.8 yrs, malignant/benign pancreatic tumor 25/3 and CGM data of 4.6 ± 3.2 days. Time in target range (140-180 mg/dL) was between 13-27% and time above range was ≥48 % in both cohorts. Time <70 mg/dL was significantly higher in cohort 2 vs. cohort 1 (p=0.03). Overall, mean absolute relative difference (MARD) was 17.2% (± 4.9), median ARD was 19.4% and number of readings meeting % 20/20, was 68% with least accuracy on day 1. There was no device related adverse event.

Conclusion: Hospitalized TP patients spend more time above and below target range than within the target range demonstrating unmet needs of better glucose monitoring and better glycemic control.

Disclosure

S. Rizvi: None. A. Banerjee: None. R. Kaur: None. S. Gupta: None. C. Reid: None. D. Desjardins: None. M.L. Kendrick: None. M. Truty: None. Y.C. Kudva: Research Support; Dexcom, Inc. Other Relationship; Tandem Diabetes Care, Inc., Medtronic.
The Problem of Road Bitumen Technological Aging and Ways to Solve It: A Review
Authors:   Lviv Polytechnic National University, 12 S. Bandery St., 79013 Lviv, Ukraine, Donchenko Myroslava , Grynyshyn Oleg ,   Lviv Polytechnic National University, 12 S. Bandery St., 79013 Lviv, Ukraine, Prysiazhnyi Yuriy ,   Lviv Polytechnic National University, 12 S. Bandery St., 79013 Lviv, Ukraine, Pyshyev Serhiy ,   Lviv Polytechnic National University, 12 S. Bandery St., 79013 Lviv, Ukraine, Kohut Ananiy ,   Lviv Polytechnic National University, 12 S. Bandery St., 79013 Lviv, Ukraine
Published: June 2024

This paper discusses the main features of technological aging of bitumen, in particular, the mechanisms and transformations that accompany this process. The main laboratory methods for modeling the above processes are considered. It is described how the technical essence of the methods has changed from the first developments to the present. A number of compounds that can be used as inhibitors of technological aging, including antioxidants and plasticizers, as well as some “natural” substances that have these properties, are presented.
A Case of Oncocytoma of Adenomhypophysis Discovered by a Head Injury
Authors: D’Assise Masina Ndalana , Sandra Rakotozanany Patrick , Miantsa Harimbonona Zo , Willy Ratovondrainy , Seizeur Romuald , Magro Elsa
Published: June 2024

Adenohypophysis oncocytoma is a rare tumor of the pituitary region. In clinical and biological terms, the oncocytomas with fusiform cells are identical to other sellar tumors. We report a new case of oncocytoma of adenomhypophysis discovered by a head injury. The only diagnosis was confirmed by the presence of richly vascularized fusiform tumor cells whose cytoplasm is oncocyte and contains many mitochondria with no necrosis and some mitoses in anatomopathologic examination. The basic treatment is surgical excision by the endonasal endoscopic route. Radiotherapy and surgical revision are essential in the event of tumor recurrence.
Extended Post-Traumatic Pneumorachis: A Case Report and Review of the Literature
Authors: Lahlou Salma , Baayoud Karim , El Khamouye Amine , Chellaoui Abdelmajid , Ibahiouin Khadija , Lakhdar Abdelhakim
Published: June 2024

Pneumorachis is an uncommon condition wherein air infiltrates the spinal canal. The pathophysiology of this condition is still a matter of debate, depending on the type of traumatic mechanism (open or closed) and the assessment of the associated injuries. This report aims to present a case of pneumorachis and comprehensively review the literature to gain a better understanding of the etiologies, associated lesions, and neurological symptoms. By doing so, we hope to enhance our knowledge of the management and modalities of treatment for this condition. Although there are many cases of pneumorachis reported in the literature, none are widespread.
Wie Digitalisierung die Wettbewerbsposition der Bahn im Fernverkehr verändert
Authors: Krämer Andreas , Bongaerts Robert
Published: June 2024

Die Deutsche Bahn hat es im Fernverkehr bisher nicht geschafft, den Faktor Digitalisierung zu nutzen, um darüber strategische Wettbewerbsvorteile aufbauen oder Defizite in der Kundenwahrnehmung entscheidend abbauen zu können. Im Gegenteil: Eine Analyse der vergangenen drei Jahre verdeutlicht, dass von den veränderten technologischen Rahmenbedingungen vor allem die neuen Wettbewerber der Bahn – Fernlinienbusse und Mitfahrzentralen – profitiert haben (zudem auch der klassische Privat-PKW, der zukünftig als vernetztes Fahrzeug vermarket wird). Für die zukünftige Wettbewerbsstellung des Bahnfernverkehrs werden fünf Thesen aufgestellt und diskutiert.
Sharing: Nische oder Massenmarkt?
Authors: Foljanty Lukas , Gossen Maike , Ruoff Paula
Published: June 2024

Die noch jungen Phänomene Car-, Ride- und auch Bikesharing zählen zu den derzeit am häufigsten diskutierten Mobilitätstrends, von denen disruptive Wirkungen ausgehen sollen. Trotz des dynamischen Wachstums der Sharing-Branche haben sie bislang allerdings noch keinen relevanten Anteil am Gesamtverkehrsmarkt. Noch jünger ist die Forschung zur Shared Mobility und ihrer tatsächlichen Wirkungen. Das Projekt „ShareWay“ hat in einem umfassenden Wissenskompendium den aktuellen Stand von Forschung und Praxis zur Shared Mobility zusammengetragen und Entwicklungsperspektiven beleuchtet.
App-Daten für die Radverkehrsplanung
Authors: Lißner Sven , Francke Angela , Chernyshova Olena , Becker Thilo
Published: June 2024

Auch durch die mittlerweile sehr hohe Verbreitung von Smartphones und die Förderung digitaler Innovationen im Mobilitätsbereich durch das Bundesministerium für Verkehr und digitale Infrastruktur (BMVI) stehen Themen wie Crowdsourcing, Citizen- Science und GPS-Datenerfassung aktuell stark im Fokus. Das nachfolgend vorgestellte Projekt wird durch das BMVI im Rahmen des Nationalen Radverkehrsplans 2020 gefördert und untersucht die Nutzbarkeit von mit Smartphones generierten Nutzerdaten einer App für die kommunale Radverkehrsplanung.
Optionen einer Dekarbonatisierung des Verkehrssektors
Authors: Zimmer Wiebke , Blanck Ruth , Cyganski Rita , Peter Martin , Dünnebell Frank
Published: June 2024

Mit dem Projekt Renewbility III konnte gezeigt werden, dass eine vollständige Dekarbonisierung des Verkehrssektors machbar ist. Hierfür gibt es verschiedene Optionen, wobei diese unterschiedliche Chancen/ Risiken-Profile aufweisen. Grundsätzlich kann eine Dekarbonisierung des Verkehrssektors bei geeigneter Ausgestaltung die Chance bieten, Klimaschutz bei positivem volkswirtschaftlichem Ergebnis zu erreichen. Aufgabe der Politik ist es nun, die Elektromobilität und damit die Effizienz der Fahrzeuge voranzubringen und das Verkehrssystem so umzugestalten, dass es durch Verlagerung und Vermeidung effizienter wird.
Verkehrssystemforschung am DLR - Mobil in Deutschland 2040
Authors: Seum Stefan , Goletz Mirko , Kuhnimhof Tobias
Published: June 2024

Szenarien zukünftiger Entwicklungen des Verkehrssystems leisten einen wichtigen Beitrag zur Unterstützung von Entscheidungsprozessen. Das ist auch das Ziel der DLR-Szenarien im Projekt Verkehrsentwicklung und Umwelt (VEU). Für die Entwicklung von Szenarien stehen verschiedene methodische Ansätze zur Verfügung. Die Vor- und Nachteile werden im nachfolgenden ersten Teil des Beitrags erörtert und das Vorgehen im Rahmen der VEU-Szenarien dargestellt. In einem zweiten Teil des Beitrag werden in der nächsten Ausgabe die Storylines der entwickelten VEU-Szenarien präsentiert.
Die digitale Zukunft über den Wolken
Authors: Mason Andy
Published: June 2024

Das Internet der Dinge (IoT) könnte die technologische Entwicklung in der Luftfahrt schon bald rasant verändern. Auch deutsche Unternehmen wie der Augsburger Embedded Computing-Hersteller Kontron sehen ihre Rolle im datengetriebenen Verkehrswesen von morgen. Ein Gespräch mit Andy Mason, Vice President Systems & Program Manager für die Bereiche Aviation, Transportation und Defense bei Kontron, im Vorfeld der Aircraft Interiors Expo (AIX).
Beitrag des Schienengüterverkehrs zur Energiewende
Authors: Lobig Anika , Liedtke Gernot , Knörr Wolfram
Published: June 2024

Die Verlagerung von Güterverkehren von der Straße auf die Schiene kann einen Beitrag zur Senkung des Energieverbrauchs im Verkehr leisten. Eine Studie im Auftrag des BMVI hat das Ziel, die Verlagerungspotenziale auf den Schienengüterverkehr und die Wirkungen auf den Endenergieverbrauch und die CO2-Emissionen abzuschätzen. Die Ergebnisse zeigen, dass eine wirksame Reduktion nicht alleine durch infrastrukturelle und technologische Maßnahmen erreicht werden kann, sondern durch eine Umgestaltung des Schienengüterverkehrssystems hin zu innovativen Dienstleistungskonzepten unterstützt werden muss.
„Ihre Route wird neu berechnet“
Authors: Glossner Johannes , Wallmann Dieter
Published: June 2024

Staus und unvorhergesehene Hindernisse kommen die Logistik teuer zu stehen: Sie kosten Zeit und zusätzlichen Sprit. Eine Lösung besteht darin, die aktuelle Verkehrslage in Echtzeit auszuwerten und Informationen miteinander auszutauschen. Zu diesem Zweck bedarf es eines flächendeckenden Breitbandnetzes und Diensten, die aus großen Datenmengen blitzschnell die passende Route ableiten.
Auf digitalen Wegen
Authors: Wagner Elena
Published: June 2024

Wo befindet sich meine Sendung, wann kommt meine Bestellung an? Kunden und Empfänger von Waren erwarten diese Informationen in Echtzeit. IDS Logistik wird diesem Anspruch gerecht und hat mit digitalen Lösungen die Produktivität weiter gesteigert.
Zukunft der Mobilität 2025+
Authors: Neuburger Rahild
Published: June 2024

Die neue Zukunftsstudie Münchner Kreis Phase VII stellt das Thema vernetzte, intelligente Mobilität in den Mittelpunkt. Im Vordergrund stehen dabei nicht jene, häufig in Studien diskutierte Themen wie die Auswirkungen der Digitalisierung auf etablierte Wertschöpfungsstrukturen oder die Frage, wer die zukünftige Schnittstelle zum Kunden besetzt. Vielmehr geht es um eine ganzheitliche Betrachtung der Mobilität, wie sie sich im Zuge der digitalen Transformation zukünftig darstellen wird.
Polizeiliche Mobilität der Zukunft
Authors: Geis Isabella , Steindl Alina
Published: June 2024

Veränderungen in der Fahrzeugtechnologie, wie alternative Antriebe oder vernetzte Fahrzeuge, beeinflussen nicht nur die zivile Mobilität. Auch Fahrzeuge von Behörden und Organisationen mit Sicherheitsaufgaben (BOS), beispielsweise Polizeibehörden, stehen vor Veränderungen, die bislang wenig Beachtung in der Forschung finden. Auf Grundlage einer Untersuchung des Fraunhofer IML wird gezeigt, welche Rolle alternative Antriebstechnologien für Funkstreifenwagen spielen und was durch V2X-Kommunikation auf Polizeibehörden als Chancen und Herausforderungen zukommt.
Ein Weihnachtsgeschenk aus Europa
Authors: Knauff Matthias
Published: June 2024

Die Verordnung (EU) 2016/2338 zur Änderung der VO 1370/07 hinsichtlich der Öffnung des Marktes für inländische Schienenpersonenverkehrsdienste tritt am 24. Dezember 2017 in Kraft. Die Änderung zielt im Kern auf eine Stärkung des Wettbewerbs im Eisenbahnsektor ab. Der Beitrag stellt die wesentlichen Neuerungen und deren Konsequenzen dar.
Anforderungsgemäße und konsistente Systementwicklung
Authors: Manz Hansjörg
Published: June 2024

Anforderungen an ein technisches System im Schienenverkehr ergeben sich aus einer Vielzahl von Eingangsdokumenten wie beispielsweise Normen, Gesetzen oder Dokumenten des Betreibers. Dieser Beitrag stellt eine Analyse und strukturierte Darstellung von Anforderungen als Basis für eine anforderungsgemäße und konsistente Systementwicklung unter Beachtung der Vorgaben aller Beteiligten dar. Dieses Vorgehen ist im Schienenverkehr aufgrund der Sicherheitsrelevanz von Systemen von besonderer Bedeutung.
Managing public transport in Windhoek
Authors: Riehle Ernst-Benedikt , Hein Ursula
Published: June 2024

The Sustainable Urban Transport Master Plan (SUTMP) aims at developing a sustainable, affordable, accessible and efficient public transport system for Windhoek. The “MoveWindhoek” project, a Namibian-German coalition, addresses the challenge to implement a modern public bus system through a diversified, long-term approach. It includes the modernisation of the bus fleet, capacity development, awareness campaigns as well as steering and funding models. It is implemented by City of Windhoek, withsupport from the Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ) GmbH.
Die Mobilisierung von preissensibler Nachfrage in einer digitalisierten Welt
Authors: Krämer Andreas
Published: June 2024

In den letzten Jahren wurde Reisen in Deutschland günstiger, und zwar nicht nur aufgrund vergleichsweise niedriger Kraftstoffpreise, sondern auch aufgrund eines verstärkten Wettbewerbs. So entstand durch die Marktliberalisierung von Fernbusreisen ein völlig neues Marktsegment. Auch der Markt für Mitfahrgelegenheiten entwickelt sich dynamisch weiter. Jüngste Gegenbewegungen zeigen sich im Airline-Bereich: Nach der Air Berlin-Insolvenz wird der Lufthansa vorgeworfen, ihre Monopolstellung auszunutzen und die Ticketpreise anzuheben. Marktbeherrschende Stellungen liegen aber auch in den anderen Sparten vor: Flixbus bei Fernbusreisen, BlaBlaCar bei Mitfahrgelegenheiten und die Deutsche Bahn im Schienenfernverkehr.
Vernetzte Logistik per Smartphone-App
Authors: Tonne Monika
Published: June 2024

Lieferscheine in Papierform sind nicht mehr zeitgemäß. Ob Auftragsdaten, optimierte Routen oder digitale Unterschrift – alle wichtigen Informationen können heute per App automatisch und sicher ausgetauscht werden. Dadurch findet eine Vernetzung entlang der gesamten Lieferkette statt.
Intelligente Bildverarbeitung
Authors: Steck Eric
Published: June 2024

Die Automatisierung logistischer Prozesse entlang der Wertschöpfungsketten beinhaltet unter anderem die vollautomatische Überwachung und Registrierung der Ein- und Ausgänge von Waren in der Transport- und Logistikbranche.
In-service condition monitoring of rail tracks
Authors: Baasch Benjamin , Roth Michael , Groos Jörn Christoffer
Published: June 2024

Low-cost on-board sensors provide the possibility of cost-effective in-service rail track monitoring. This will allow a major step forward towards condition-based preventive maintenance that might reduce maintenance cost significantly compared to today’s corrective maintenance schemes. Here, we present a prototype multi-sensor system for quasi-continuous track condition monitoring. This system has been tested in operational environment since 2015, allowing the development and verification of multi-sensor-fusion and processing techniques as presented in this article.
Sicherer Bahnhof
Authors: Asmer Lukas , Popa Andrei
Published: June 2024

Das Schienenverkehrsnetz in Deutschland zählt zu einem der am besten ausgebauten, aber ebenso komplexesten Verkehrssysteme der Welt. Dabei zeichnet sich das System vor allem durch freie Zugangsmöglichkeiten und eine hohe Flexibilität für die Reisenden aus. Vor dem Hintergrund der Bedrohung durch den internationalen Terrorismus steigt die Forderung nach Sicherheitskontrollen im Schienenverkehr. Welche Auswirkungen flughafenähnliche Sicherheitskontrollen auf den Fahrgastfluss an einem Bahnhof hätten, untersuchte das DLR-Institut für Flughafenwesen und Luftverkehr in einem Forschungsprojekt.
Blockchain-Anwendungen in der Logistik
Authors: Jockel Otto , Stommel Sebastian
Published: June 2024

Aufgrund ihrer Eigenschaften birgt der Einsatz der Blockchain-Technologie auch für Logistik- bzw. Supply Chain-Prozesse Innovationspotential. Das belegt eine zunehmende Anzahl dahingehend begonnener Projekte. Das Potential von Blockchain-Anwendungen erschließt sich aus den generischen Eigenschaften eines Blockchain-Protokolls wie Proof-of-Work/Stake, Proof-of-Authenticity und Smart Contracts. Mögliche Anwendungen in der Logistik bzw. dem Supply Chain-Management sind Dokumenten-Blockchains, Smart Monitoring und blockchain-gesteuerte Prozesse.
Wo fehlt was?
Authors: Krajzewicz Daniel , Nieland Simon , Narezo Balzaretti Jorge , Heinrichs Dirk
Published: June 2024

Erreichbarkeitsmaße verschieben den Fokus der Betrachtung des Mobilitätsangebots auf die Verteilung der Aktivitäten im Raum und die Möglichkeiten des Erreichens dieser mittels verschiedener Verkehrsträger und -modi. Sie werden als Paradigmenwechsel zugunsten einer umweltfreundlichen Mobilität angesehen. Doch werden Erreichbarkeitsmaße oft mit komplexen, teilweise modellgestützten Annahmen angereichert und zumeist in Choroplethen dargestellt, wodurch eine einfache Interpretation der Ergebnisse in der Praxis nicht immer gewährleistet ist. Dieser Artikel beschreibt eine Methode zur Verarbeitung von Erreichbarkeitsmaßen mit dem Ziel, Bereiche mit potentiell unzureichender Versorgung auf eine leicht verständliche Art und Weise quantitativ zu erfassen und darzustellen.
Perspektiven zur Neuen Seidenstraße
Authors: Schodl Reinhold , Breinbauer Andreas , Eitler Sandra
Published: June 2024

Mit der Belt and Road-Initiative hat die Volksrepublik China ein globales Infrastrukturprojekt ausgerufen, welches die Handels- und Transportstrukturen fundamental ändern soll. Im deutschsprachigen Raum wird das Vorhaben als Neue Seidenstraße intensiv diskutiert, wobei konkrete Auswirkungen vielfach ungeklärt bleiben. Eine Befragung unter Entscheidungsträger/innen in der österreichischen Transport- und Logistikbranche widmet sich deshalb der wahrgenommenen Bedeutung, den erwarteten Chancen und Risiken sowie den unternehmerischen Reaktionen.
Der Weg zur digitalen Bahn
Authors: Tokody Daniel , Holicza Peter , Tor Maria
Published: June 2024

Mit dem Europäischen Forschungsrahmenprogramm „Horizon 2020“ soll eine intelligente und nachhaltige Wachsstumsstrategie in Europa Realität werden. Die Gestaltung eines intelligenten und ökologisch integrierten Verkehrssystems gehört unabdingbar dazu. Und so wurde Shift2Rail ins Leben gerufen, eine Technologieinitiative (JTI) im Bahnbereich, die als öffentlich-private Partnerschaft Qualität und Effizienz des Schienenverkehrs mit innovativen Verfahren verbessern soll. Ziel ist es, einen einheitlichen europäischen Eisenbahnraum (Single European Railway Area, SERA) zu schaffen, der den Umstieg von der Straße auf die Schiene erleichtern soll: umweltfreundlich, nachhaltig und als Teil des sicheren Verkehrssystems in Europa. Im Fokus stehen Digitalisierung und Informations- und Kommunikations-Technologien - allerdings keine einheitliche Strategie.
Proaktive Disposition luftverkehrlicher Prozesse
Authors: Tidemann Markus , Martin Ullrich
Published: June 2024

Die Durchführung luftverkehrlicher Prozesse ist in hohem Maße vom volatilen Verkehrsaufkommen abhängig. Um einerseits aus Sicht des Flughafenbetreibers die Nachfragespitzen im Sinne eines verringerten Ressourcenbedarfs abzuschwächen und andererseits die Servicequalität für Fluggäste unter dem Aspekt reduzierter Wartezeiten zu steigern, soll ein proaktiver Dispositionsansatz im Luftverkehr etabliert werden. Zu dessen Weiterentwicklung wurden am Beispiel des Stuttgarter Flughafens die Zeitbudgets abfliegender Passagiere analysiert.
Peran Shooping Life Style Sebagai Variabel Mediasi Antara Hedonic Shooping Value Dan Utilitarian Value Terhadap Impulse Buying Pada Mahasiswa Fakultas Ekonomi Dan Bisnis Universitas Muhammadiyah Metro
Authors: Selamet Fuadi  , Yateno  , Bergita Novilan
Published: June 2024

Shopping is generally just buying the materials or products that are needed, but with the many variations of various products today, students of the Faculty of Economics and Business at Muhammadiyah Metro University spend more time choosing materials or products that are not only needed but also wanted and cause purchases suddenly without regard to the benefits of these goods. The factors that encourage students to do impulse buying include promotions/discounts, attractive models or just satisfying feelings. This research was conducted at Muhammadiyah Metro University. This study aims to determine the role of shopping lifestyle as a mediating variable between hedonic shopping values ​​and utilitarian values ​​on impulse buying in students of the Faculty of Economics and Business, University of Muhammadiyah Metro. This study used 92 respondents as the research sample and the sampling technique used accidental sampling. The data analysis method used is a quantitative analysis method including equation test, model test and hypothesis test. The results of this study indicate that the two independent variables, namely hedonic shopping value and utilitarian value, have an effect on impulse buying and the shopping lifestyle variable mediates these two variables so that each variable has an effect on impulse buying.
Pengaruh Budaya Organisasi Dan Lingkungan Kerja Terhadap Kinerja Karyawan Dengan Motivasi Sebagai Variabel Moderating Pada Toko Taqwa Mulia Batanghari
Authors: Suryadi  , Slamet Tedy Siswoyo  , Nila Tri Lestari
Published: June 2024

The purpose of this research was to find out whether there was an influence of organizational culture and working environment towards the employee performance with motivation as a moderating variable at the taqwa mulia store at Batanghari sub-district. The research Methods applied Descriptive and quantitative approaches. The population and sample were the employees of taqwa mulia shop at Batanghari sub-district, with a total of 38 employees. The data collection technique used a questionnaire.  The research data were analyzed by testing the prerequisites instrument, namely the Pearson product moment validity test. Furthermore, the reliability test used the Cronbach alpha test. Furthermore, to test the research hypothesis, the researcher utilized normality test, linearity test and homogeneity test. Next, a multiple linear regression test, T test, F test were performed and tested with the moderating variable in order to analyze the data of this study. Furthermore, data analysis were undertaken through moderated regression analysis (MRA) with the SPSS program. Based on the results of this study, it showed that: 1) organizational culture influenced the employee performance. 2) the working environment had a positive effect on the employee performance, 3) the organizational culture which was moderated by motivational variables had an acceptable value, so it can be concluded that motivational variables are able to moderate organizational culture on the employee performance. 4) the working environment is moderated by the variable motivation which has an acceptable value. Based on these results it can be concluded that the motivational variable is able to moderate organizational culture on employee performance.
 
Keywords ; Organizational Culture, Work Environment, Employee Performance, Motivation
Pengaruh Harga Dan Cita Rasa Terhadap Keputusan Pembelian Mie Instan Indomie Dengan Citra Merek Sebagai Variabel Intervening (Studi Kasus Pada Mahasiwa Manajemen Angkatan 2019 FEB Universitas Muhammadiyah Metro)
Authors: Durotun Nasikah  , Ratmono  , Rina Eka Mayanti
Published: June 2024

The purpose of this research was to find out whether price had an effect on brand image. Tofind out whether taste had an effect on brand image. To find out whether the price affects thepurchase decision. To find out whether taste had an effect on purchasing decisions. To findout whether the price and the taste affect purchasing decisions with brand image as theintervening variable. The sample of this research was 58 Management Batch Students of the2019 in Muhammadiyah University of Metro. Data were collected through questionnairesheets, and the data analysis used validity test, reliability test, normality test, homogeneitytest, linearity test of significance regression, and path analysis using the program (SPSS).The results showed that the price and the taste had a positive and significant effects onpurchasing decisions, the price and the taste had a positive and significant effects on brandimage, and the price and the taste had positive and significant effects on purchasingdecisions with brand image as the intervening variable.
Pengaruh Budaya Layanan, Customer Value, Dan Brand Equity Terhadap Loyalitas Nasabah Produk Pembiayaan Pensiun Di Bank Syariah Indonesia KC Bengkulu Sudirman
Authors: Ella Ariyani  , Idwal B  , Aan Shar
Published: June 2024

The aim of this research is to determine the influence of service culture, customer value andbrand equity on customer loyalty for pension financing products at Bank Syariah IndonesiaKC Bengkulu Sudirman. This research uses quantitative methods with multiple linearregression analysis methods. The samples used were 110 samples determined by purposivesampling. The results of this research show that simultaneously service culture, customervalue and brand equity have a positive and significant effect on customer loyalty for pensionfinancing products at Bank Syariah Indonesia KC Bengkulu Sudirman, this is proven by thecalculated F value of 66,541 and a significant value of 0.000 < 0.05. Partially 1) serviceculture has a positive and significant effect on customer loyalty with a significant value of0.000 < 0.05. 2) customer value has a positive and significant effect on customer loyalty witha significant value of 0.000 < 0.05. 3) brand equity has a positive and significant effect oncustomer loyalty with a significant value of 0.000 < 0.05
Метод поетапного розподілу соціальних послуг між виконавцями
Authors: Кикина Є. Б.
Published: June 2024

Цифровізація сфери публічного управління спонукає до розробки нових ефективних
механізмів супроводу основних процесів прийняття рішень. Дослідження зосереджено на
розробці моделі та методу оптимізації процесів розподілу робіт між виконавцями
соціальних послуг для уразливих груп населення. Виконано математичну постановку задачі
розподілу послуг між виконавцями, яка дозволяє враховувати запити від отримувачів, їх
ступені відповідності вимогам, що ставлять до отримувачів, а також кількості
отримувачів, яким одномоментно може надаватися кожна конкретна послуга. Пропонується
зводити цю задачу до задачі одно чи багатокритеріальної задачі лінійного програмування з
булевими змінними. Розроблено ітераційний метод поетапного розподілу послуг, який
інтегрує вже встановлені відповідності між потребами отримувачів і можливостями
виконавців. Вхідними даними в методі є не тільки об’єктивні дані, які характеризують
отримувачів і виконавців послуг, а й оцінки, отримані від експертів чи особи, що приймає
рішення. Враховується не лише пріоритетність отримувачів, але й специфічні послуги, які
можуть надавати виконавці. Метод дозволяє ефективно адаптуватись до змін у потребах та
ресурсах, а також вводити нові запити без переривання вже наявних процесів.
Науковий внесок дослідження полягає у розробці методу та практичного підходу до
розподілу соціальних послуг, який може бути використаний для проектування програмних
продуктів, що підтримують відповідні процеси прийняття рішень. Подальші дослідження
можуть включати розробку інструментів для прогнозування майбутніх потреб у соціальних
послугах, що розширить можливості адаптації до змінюваних умов обслуговування.
Сегментація ринку криптовалют за трендами вартості
Authors: Кондрук Н. Е. , Зінченко М. О. , Крічфалушій О. І. , Пендлишак Т. В. , Рябицька М. О.
Published: June 2024

У сучасному свiтi ринок криптовалют постiйно еволюцiонує, вiдзначаючи значнi змiни
та тренди, якi впливають на їхню вартiсть. Серед широкого спектру криптовалютних активiв
стежити за цими трендами стає все складнiше та важливiше, оскiльки вони не лише
вiдображають ринкову активнiсть, але i вказують на потенцiйнi можливостi та ризики для
iнвесторiв та регуляторiв. Актуальнiсть задачi полягає в необхiдностi розумiння динамiки
цього сектору, адаптування iнвестицiйних стратегiй до змiн у цiновiй динамiцi та попитi
на рiзнi види криптовалют. В ходi роботи сформовано набiр даних рiчної вартостi 200
рiзновидiв криптовалют в несприятливому для розвитку криптовалютного ринку часовому
перiодi. Проведено сегментацiю криптовалют за динамiкою вартостi криптовалютних активiв
на основi лiнiй трендiв, моделей k-середнiх та “лiктя”. В результатi, визначено 7
кластерiв та описано їх змiстовну iнтерпретацiю. Проведений аналiз може допомогти
розробити стратегiї управлiння ризиками та прийняття рiшень для iнвесторiв та учасникiв
ринку криптовалют.