bluuebunny/crossref_metadata_2025 huggingface dataset:
A Suitable Boy: Blurring the Line Between Fiction and Non-Fiction
Authors: Dr. Charu Mehrotra
Published: May 2022

Vikram Seth was the son of a judge and a businessman was raised in London and India. He has written about a variety of themes and topics including music, travel, work environments, family, homosexuality and Catholic belief. He wrote poetic novel The Golden Gate and turned to prose in his epic novel, A Suitable Boy. It functions as a political fable, a roman a clef, showing the emerging polity of the newly independent India. Seth has used a variety of characters to show how in the very first decade after independence the mood of the people changed from euphoria to despondence. While debating the role of students in politics, Seth briefly mentions his central theme thus, “Their post-independence romanticism and post-independence disillusionment formed a volatile mixture” (p. 815). His diagnosis-vote-bank politics and communalism as an election tool have corroded the soul of the fledgling Indian democracy.
Theme of Redemption in Eliot’s The Family Reunion
Authors: Dr. Rani Tiwari
Published: May 2022

Thomas Sterns Eliot’s second full length poetic play, The Family Reunion is known for its modernity in the matter of expression but medievalism for its contents. Nobody can ignore its importance about its recognition and contribution as a modern play. With this play Eliot presented different kinds of religious modernistic themes. It shows a kind of mirror to the psychological state of human beings. Eliot has presented the spiritual struggle of a lonely character, Harry who is suffering from the hallucination and experiences of having involvement in the act of sinister and desire for its atonement. Harry seems to be unavoidably burdened with the curse which is related to his familial background. Ultimately, he decides to expiate for the same. His feelings of expiation become so strong that he resigns the comfortable ways of life at the place where his family used to reside, the name of the place has been described as Wishwood although none of the wishes seems finely been perfected. He follows the path of self-denial for gaining redemption for himself and his community. Different kinds of mythical and religious images have been used and created to prove its religious concerns.  The alteration of Eumenides from hounds of hell is justified not only by “Oresteia of Aeschyus. With this play, Eliot has tried to explain the idea that suffering leans to atonement. Eliot attempted to connect the classical with the modern. This play has two levels of reality. On the surface level, there is a reunion of the family members of Harry. On the deeper level, Furies pursue Harry. Agatha helps Harry to follow the bright angels. He suffers for redemption. This play reflects Eliot’s recurrent preoccupation with Original Sin. The play is remarkable to greater concerns which is related to a purgatorial confrontation between the human spirit and the Divine spirits which may be called as the Supreme Power. Eliot emphasizes the possibility of salvation through redemption.
Malattia di Behçet: una sfida per il pediatra
Authors: Levantino Laura , pastore Serena , Corona Federica , Lepore Loredana , Tommasini Alberto
Published: May 2022

Behçet’s disease (BD) is a rare chronic inflammatory condition associated with variable-vessel vasculitis, systemic involvement and relapsing course. It is characterized by a wide clinical heterogeneity, presenting with mucocutaneous, ocular, articular, gastrointestinal, neurological and vascular manifestations in the long term, with a high risk of delay in diagnosis: therefore, its morbidity and mortality are significant. The definition of BD probably encompasses a range of disorders with unclear pathogenesis, overlapping autoinflammatory and autoimmune pathological mechanisms. Diagnosis is clinical and multiple classification criteria have been developed. The progressive knowledge about its molecular basis, especially in the so-called monogenic mimics of BD, resulted in an improvement in the disease therapy, with an optimization of the use of conventional immunosuppressive agents and the introduction of new biologic drugs. BD occurs in childhood in up to 20% of cases: paediatric BD differs from adult BD in frequency and severity of clinical findings, and, above all, for a frequent incomplete clinical picture, making the recognition and management of the disease a challenge. The new paediatric classification criteria are aimed to allow an early diagnosis and a proper therapy.
Ethnobotanical survey of medicinal plants against ophidian envenomations in the Bonginda/Bikoro Group in DR Congo
Authors: Blaise Engomba MOKEKOLA  , Rombeau Tamasala NDOMBE  , Raphaël Kalima MWANGE  , Aristarque Bulambo MULONDA  , Florent Biduaya MUKEBA  , Zacharie Kusamba CHIFUNDERA  , Assumani Zabo IDRISSA
Published: May 2022

Snakebite envenomation is a neglected tropical disease causing enormous suffering, disability and premature death on all continents. This study aims to inventory the plants involved in the management of snakebite cases in rural areas. A survey was conducted in the Bonginda groupement, Bonginda Territory, Equateur Province in DR Congo during the period from January 2019 to December 2020. Data was collected by the standardized interview method with a focus on individual interview technique. To this end, a questionnaire was administered to traditional healers reputed in the treatment of snakebites. It shows that 17 species grouped into 14 families are used to treat cases of ophidian envenomation in Bonginda. The Fabaceae and Rubiaceae families each have 3 species. The others are monospecific. Among the organs used, leaves predominate with a score of 44.4%. They are followed by the roots (18.5%). Regarding the mode of preparation, the decoction prevails with 27.3%. It is followed by grinding (13.6%). As for the route of administration, local application (28.6%) is ahead of the oral route (23.8%) and purgation (14.3%). Constituents based on medicinal plants are recognized as local heritage.
Clinical, Radiological, and Outcome Characteristics of Acute Pulmonary Embolism: A 5-year Experience from an Academic Tertiary Center
Authors: H Ibrahim Wanis , Al-Shokri Shaikha D , Hussein Musa S , Abu Afifeh Lana M , Karuppasamy Gowri , Parambil Jessiya V , Elasad Farras M , Faris Mohammed E , Abdelghani Mohamed S , Abdellah Ahmed , Kamel Antoun , Ghazouani Hafedh , Ahmad Mushtaq , Aladab Aisha , Danjuma Mohammed I , Raza Tasleem
Published: May 2022

Background: Acute pulmonary embolism (PE) is a common and potentially life-threatening condition. This comprehensive study from a Gulf Cooperation Council (GCC) country aimed to evaluate the clinical, radiological, and outcome characteristics associated with acute PE.

Methods: This retrospective observational study analyzed data of patients with confirmed acute PE who were admitted to the largest academic tertiary center in the State of Qatar from January 1, 2014, to December 31, 2018. Data on the clinical presentation, radiologic, and echocardiographic findings, as well as outcomes were collected.

Results: A total of 436 patients were diagnosed with acute PE during the study period (male, 53%). Approximately 56% of the patients were < 50 years old at presentation, with a median age of 47 years. In approximately 69% of cases, the PE occurred outside the hospital. The main associated comorbidities were obesity (34.6%), hypertension (29.4%), and diabetes (25%). Immobilization (25.9%) and recent surgery (20.6%) were the most common risk factors. The most frequent presenting symptom was dyspnea (39.5%), and the most frequent signs were tachycardia (49.8%) and tachypnea (45%). Cardiac arrest was the initial presentation in 2.2% of cases. Chest X-ray findings were normal in 41%. On computed tomography pulmonary angiography (CTPA), 41.3% of the patients had segmental PE, 37.1% had central PE, and 64.1% had bilateral PE. The main electrocardiographic (ECG) abnormality was sinus tachycardia (98%). In patients who underwent echocardiography, right ventricular (RV) enlargement was the main echocardiographic finding (36.4%). Low-, intermediate-, and high-risk PE constituted 49.8%, 31.4%, and 18.8% of the cases, respectively. Thrombolysis was prescribed in 8.3% of the total and 24.4% of the high-risk PE cases. Complications of PE and its treatment (from admission up to 6 months post-discharge) included minor bleeding (14%), major bleeding (5%), PE recurrence (4.8%), and chronic thromboembolic pulmonary hypertension (CTEPH) (5%). A total of 15 (3.4%) patients died from PE.

Conclusions: Acute PE can manifest with complex and variable clinical and radiological syndromes. Striking findings in this study are the younger age of acute PE occurrence and the low PE-related mortality rate.
Physical, Chemical and Bioactive Properties of Four Different Pears (Pyrus communis L.) Varieties Grown in Turkey
Authors: COŞKUN TOPUZ Fatma , BAKKALBAŞI Emre
Published: May 2022

In this study, physical, chemical and bioactive properties of four different pear varieties (Mellaçi, Mellaki, Deveci and Margarite) grown in Turkey's eastern regions were investigated. It was determined that the length, diameter and weight values of pear varieties varied between 6.08-9.56 cm, 5.42-8.30 cm and 92.27-254.95 g, respectively. Also, glucose, fructose and sucrose amounts of pear varied between 15.43-22.83, 18.08-30.62, 1.36-14.77 g 100 g-1 d.m (dried matter), respectively. TPC, ABTS and DPPH results of pear varieties were determined 622.56-3718.43 mg GA eq kg-1 d.m, 18.35-178.90 mmol Trolox eq/g d.m and 149.49-366.07 mmol Trolox eq/g d.m, respectively. Syringic acid, chlorogenic acid, ferulic acid, ellagic acid, catechin, epicatechin and rutin were detected in pear samples. Chlorogenic acid was the major phenolic component in pear varieties. Also, it was determined that significant differences were found among pear varieties in terms of physical, chemical and bioactive properties. While the Mellaki variety showed superior properties in terms of analyzed physical properties, the Margarite variety had superior properties in terms of chlorogenic acid and antioxidant activity.
İdrîs-İ Bitlisî’nin Selîmşâhnâme Adlı Eserinin Metninin ve İkinci Müellif Olarak Ebülfazl Mehmed Efendi’nin Metne Katkılarının Üzerine Bir Değerlendirme
Authors: DEMİR Özlem
Published: May 2022

I. Selim dönemini anlatan Selimnâme türündeki eserlerden biri de İdrîs-i Bitlisî’nin Selîmşâhnâme isimli Farsça eseridir. İdrîs-i Bitlisî’nin vefatı sebebiyle müsvedde halinde kalan eser, Kanûnî’nin emriyle oğlu Ebülfazl Mehmed Efendi tarafından tamamlanmıştır. Ebülfazl Mehmed Efendi, müsveddelerin bir kısmının kaybolması ve dağıtılması sebebiyle metindeki boşlukları doldurmuştur. Metne eklenen kısımlar, eserin kime ait olduğu hakkında farklı yorumlara ve Zeyl-i Heşt Bihişt olarak değerlendirilmesine sebep olmuştur. Bu yorumlar klasik kaynaklardan modern kaynaklara aktarılarak devam etmiştir. Eser üzerinde yapılan akademik çalışmaların literatür değerlendirmesinde eserin kime ait olduğu ve Ebülfazl Mehmed Efendi’nin metne eklediği kısımların tam olarak tespit edilemediği saptanmıştır. Bu çalışma, eser üzerinde yapılan çalışmaların eksik bıraktığı yerleri tamamlamak ve Selîmşâhnâme’nin metni içerisinde Ebülfazl Mehmed Efendi’ye ait olan kısımları tespit etmek amacıyla yapılmıştır. Selîmşâhnâme’nin içeriği, İdrîs-i Bitlisî’nin ruh dünyası ve son yılları hakkında önemli bilgiler içeren Risâle-i Tîğ u Kalem ayrı bir başlık altında incelenmiştir. Metnin dışında bırakılan bu risâlenin Selîmşâhnâme’nin dîbâcesi olduğu ortaya konmuştur. Aynı şekilde, eserin tercüme edilen metnine dâhil edilmeyen Dîbâce-i Hamâ ve Humus hakkında da bilgi verilmiştir. Eserin metninde müellifle ilgili ibare bulunmayan kısımlar yorumlanmış, Ebülfazl Mehmed Efendi’nin esere eklediği bölümler tespit edilmeye ve değerlendirilmeye çalışılmıştır. Bu değerlendirmeler sonucunda, İdrîs-i Bitlisî’nin kanaatlerinin ve dünya görüşünün değişmesi sebebiyle eseri ikinci kez yazma ihtimali ileri sürülmüştür.
Pluralism in the economics curriculum
Authors: Mearman Andrew
Published: May 2022

This booklet gives examples of three ways in which economics can be taught pluralistically in a university course.
A imprensa circulista e a difusão de uma educação profissional
Authors: Leon Adriana Duarte
Published: May 2022

O presente artigo analisa a atuação da imprensa Circulista em prol da consolidação de um ideário para a educação técnico-profissional no Rio Grande do Sul na década de 1930. Este estudo se localiza no campo da História da Educação e problematiza questões referentes à consolidação de uma identidade para a educação técnico-profissional na região sul do Estado, busca-se compreender essa identidade a partir da impressa produzida pelo Circulo Operário no período estudado. Conclui-se que a atuação da Instituição articula-se com os princípios defendidos pela Igreja Católica e pelo Estado no período em questão.
A violência doméstica e familiar contra a mulher no ambiente educacional
Authors: Bernardo de Oliveira Priscila , Dos Santos Silva Suely
Published: May 2022

Esta pesquisa trata da importância de abordar a temática da violência doméstica e familiar contra a mulher (VDFM) e de problematizar essa prática no ambiente educacional com enfoque na formação continuada de educadores. Com uma revisão bibliográfica e documental, e a partir de uma metodologia qualitativa pelo olhar do método materialista histórico, foi possível compreender a constituição do desenvolvimento humano e as relações que o permeiam. Por ser uma questão cultural e presente na sociedade brasileira, é fundamental que o tema seja discutido nas escolas das cidades de Jataí e Rio Verde, no estado de Goiás. De caráter formativo e socializador, a violência contra a mulher deve ser interpelada com base em uma educação holística e democrática, fator fundamental para sua prevenção e seu enfrentamento.
Comparative assessment of the accuracy of ceramic orthodontic brackets to 0.022-inch stainless steel slots in orthodontic patients
Authors: Barbi Wagisha , Rangari Priyadarshini , Chhabada Amarpal Kour , Katiyar Shahshank
Published: May 2022

Background: Brackets are the passive components that transfer the force to the teeth by elastomeric chains, springs, and the arch wire. The arch wire placement in a bracket that is pre-adjusted is done to construct three-dimensional forces to move the tooth. Aim: The present study was conducted to compare and assess the accuracy of ceramic orthodontic brackets to 0.022-inch stainless steel slots in orthodontic patients. Materials and Methods: The present in-vitro study included a maxillary lateral incisor of the left side where 0.022 MBT American orthodontics (AO) slots as placed with 15 ceramic and 15 stainless steel brackets were placed and divided into 6 groups of 90 subjects. Software analysis was done to assess distal face and base, mesial face and base. Results: For the stainless-steel group, a statistically significant higher slot width was seen for 3M Unitek compared to Ormco and American Orthodontics (AO) slots with p<0.05. Concerning ceramic brackets, higher slot width was seen for American Orthodontics (AO) slots compared to 3M Unitek and Ormco ceramic brackets. This difference was statistically significant with p<0.05.  Conclusion: The present study concludes that inaccuracies in dimensions are seen owing to the existing difference between measured values and stated values.
Application for measurement of the influence of accountability, nationalism, public ethics, quality commitment, and anti-corruption (AQEAP) on the civil servant teachers’ performance
Authors: Riani Ni Ketut , Candiasa I Made , Yudana I Made , Dantes Kadek Rihendra
Published: May 2022

This research was conducted to know the effect of Accountability, Quality commitment, Excellent service, Anti-corruption and Public ethics (AQEAP) on the performance of civil servant teachers in Denpasar-Bali. This study used the Full Model Structural Equation Model (SEM). The populations in this study were civil servant teachers from the class of 2019 in Denpasar City. The sampling technique used was the census method, which used the entire population as the research sample. All data were collected using a questionnaire technique with a Likert scale. The SEM analysis process in this study was assisted by using IBM AMOS Version 26 software. The results showed that there was a significant influence between AQEAP on the performance of civil servant teachers in Denpasar-Bali. So it is very important to develop these five variables to support teacher performance.
Monooxygenase and dioxygenases by bacterial specific enzymes network
Authors: Esmaeel Jameela Radi , Alfatlawi M A A
Published: May 2022

Naphthalene, a polycyclic aromatic hydrocarbon (PAH), is present in different industrial sites, including combustion products of fossil products (such as coal tar and petroleum) and biofuels. It is also a chemical with a substantial quantity of commercial manufacturing. Moth repellents and toilet deodorant blocks are among the most common consumer items that include the chemical compound naphthalene. It is also widely used in the production of chemical intermediates (such as phthalic anhydrides) as well as pigments and surfactants, and in the tanning of leather. Naphthalene has critical health impact, inducing mutations and/or cancers. This review focuses on the bacterial enzymes used in the degradation of naphthalene. Naphthalene is an important contaminant of environment that can cause serious health problems. The compound can be bacterial-degraded used specific enzymes networks, such as monooxygenases, dioxygenases, dehydrogenases, etc.
Development of health mix powder to combat anaemia
Authors: Visalakshmi N , Bindu V.
Published: May 2022

In India, anaemia is a leading cause of death. According to statistics, anaemia is the cause of every maternal fatality. Anaemia is a nutritional illness that affects both adults and children of both sexes, however it is more common in pregnant women and teenage girls and is caused mostly by iron deficiency. Iron and other critical elements required for iron metabolism are abundant in leaves of Moringa oleifera. An increasing finding have found extracts of M. oleifera leaves that aqueous alcohol, or hydro alcohol have a variety of extra activities of biologically, including antiulcer, tissue protective (heart, kidneys, testes, liver, or lungs), radio protective, antioxidant, analgesic, immunomodulatory and antihypertensive properties. The Central Council for Ayurvedic Research has issued preliminary recommendations for standardising commonly used formulas. Standardization of herbal formulations is necessary for determining the quality of pharmaceuticals based on the quantity of active ingredients, as well as physical and chemical parameters. We will briefly discuss many elements of herbal medicinal properties of Moringa oleifera.
Green infrastructure to enhance urban sustainability
Authors: Alanbari Donya Hameed Ali , Alkindi Sajeda Kadim , Al_Ahbabi Shaimaa Hameed
Published: May 2022

Green infrastructure is one of the main design strategies that must be developed within the urban plans of any city, its essential role in achieving the principles of sustainability and enhance its social, economic and environmental pillars. It contributes to increasing the quality of life within urban cities, areas and vitality, as well as making it an important attraction for residents and investors and Stepping stone for spreading and enhance sustainability within the built environment. Therefore, the research problem emerged in the "Knowledge deficiency of the importance of green infrastructure in enhance urban sustainability within the built environment". Through, The research hypothesis, "Green infrastructure is one of the most important design strategies within the built environment to enhance urban sustainability by increasing the quality of life socially, economically and environmentally." The aim of the research "Utilizing green infrastructure to strengthen social, economic and environmental axes of sustainability and raise awareness of the importance and key role of this urban-level design strategy for cities".
Developing student characters to have independent, responsible, creative, innovative and adaptive competencies towards the dynamics of the internal and external world
Authors: Mulyaningsih Indrya , Ananda Rizki , Fauziddin Mohammad , Pattiasina Petrus Jacob , Anwar Miftahulkhairah
Published: May 2022

School is one place to instill character and develop potential students, both physical and spiritual potential. The main task of the school is to grow and develop the character of students to become more mature, both mature in knowledge, individually, and socially. The primary indicator of maturity is the ability and willingness to be responsible for the choice of thoughts, attitudes, and behavior. These three maturities are a reflection of the level of character quality of students. Therefore, the more mature students, both adult knowledge, individual and social, the more relevant students are. The aim of developing student characters is to have independent, responsible, creative, innovative and adaptive competencies towards the dynamics of the internal and external world. Such character development should be carried out in a planned, systematic, and measurable manner using well-tested approaches and methods. Each school can make many choices; of course, it must be adjusted to the vision, mission, and goals of the school.
Evaluation of interleukin-7 and lipid profile in breast cancer women
Authors: Abbas Maher Hatem , Alsamarai Abdulsalam Tawfeeq Salih
Published: May 2022

Breast cancer is one of the most common cancerous tumors and one of the main causes after lung cancer that leads to death, and the most common type of breast cancer is adenocarcinoma and is usually detected either during the examination before symptoms appear or after the woman notices the presence of the tumor. Breast cancer is one of the most common diseases in Iraq recently. This study was designed to measure the level of interleukin-7 and its role in cancer, as well as to find out the Level of lipids (cholesterol, triglycerides, and high-density lipoproteins) in breast cancer women and compare them with the control group. The results showed a significant increase( P≤ 0.05)  in the level of interleukin-7and high-density lipoprotein cholesterol (357.505±89.921µg\L, 104.383±20.865mg\dl) respectively among patients with breast cancer compared with the control group (150.705±39.559µg\L,114.782±14.139mg\dl) respectively, , and the results showed a significant decrease ( P≤ 0.05) in the level of cholesterol a and triglycerides in patients with breast cancer (104.383±20.865mg\dl , 110.388±18.180mg\dl) respectively compared with the control group(114.782±14.139mg\dl, 138.925±23.178mg\dl) respectively.
Comparison of topical agents versus invasive agents in facial acne
Authors: Tiwari Rahul V. C. , Sahu Debasis , Sharma Akshat , Managutti Anil , Mathew Philip , Mathai Paul , Kumar Abhinav
Published: May 2022

The purpose of this present research was to compare the application of topical agent and invasive agent for treatment of facial acne. A total of 124 patients with mild to moderate acne entered this prospective, single-blind study comparing topical (benzoyl peroxide 5%) with invasive treatment (microneedling). There were 60 female and 64 male subjects in the present research. Reductions in the mean number of inflamed and non-inflamed lesions were compared using Student's t-test, as were the mean grades for skin tolerability. The incidence of self reported adverse effects were compared using the x' test. A significant difference was noted in baseline assessment of facial erythema between the two groups (P<0.05), being greater in the microneedling group. Comparisons between the two groups showed that microneedling was significantly better than at one month (P<0.05), however benzoyl peroxide 5% was better at two months (P< 0.001), and three months (P<0.001). Microneedling was effective in removing the comedones with immediate effectiveness but the effects were not long lasting with possibility of scar formation when compared to benzoyl peroxide, who didn’t have relapses in the treatment and were cost effective as well.
The model of dynamic capability on slow fashion: A dynamic view
Authors: Yi-Sheng Wang
Published: May 2022

In the past, the research on slow fashion was always directed into business unit strategy or resource-based theory as the main point of view for the enhancement of competitive advantages; however, the discussion on business unit in the past, focused on the sharing and expansion of the firm and structural unit more. In addition, the resource-based theory also focused on the controversy of dynamic point of view caused by the internal resource uniqueness of the firm too much. In this study, in order to understand the real situation of slow fashion, CHANEL, DIOR, BURBERRY and HERMES, were selected as the objects, focusing on 32 high-level managers of slow fashion. This study used grounded theory, open coding, axial coding, select coding to analyze and proposed theoretical propositions in the end. The contribution of this study is to show the insights of “the model of dynamic capability on slow fashion”, in hoping to propose the academic referential index and a good operational direction of retail market managers in slow fashion.
EFEITO DA APLICAÇÃO DE ULTRASSOM EM SEMENTES NO DESEMPENHO DE MUDAS HYMENAEA COURBARIL L.
Authors: D'avila Luz Patricia Velásquez , Vela Navarro Zandra Pilar , Santos Isaac de Oliveira , Souza Ronald Antonio Nascimento de , Ribeiro Ítalo Felipe Nogueira , Alves William Ferreira , Maggi Luis Eduardo , Rodriguez Anselmo Fortunato Ruiz , Pereira Wagner Coelho de Alburquerque , Silva Marcelo Castanheira da
Published: May 2022

A espécie Hymenaea courbaril L., apresenta potencial econômico na comercialização de sua seiva e na indústria madeireira da Amazônia, bem como elevada importância para a medicina popular e construção civil. Sendo assim, este trabalho avaliou o desempenho de plântulas após a aplicação de ultrassom em sementes de Hymenaea courbaril L. No experimento usou-se duas temperaturas de 30 ºC e 35 ºC e quatro grupos com quatro repetições de 25 sementes cada, sendo o grupo controle e três grupos com aplicação de ultrassom na frequência de 3 MHz, intensidade de 2 W/cm² por 2 minutos (T2), 3 minutos (T3) e 4 minutos (T4). Avaliou-se as variáveis de comprimento e massa seca e fresca da parte aérea e radicular.  De acordo com os resultados, houve uma redução de massa fresca da raiz e um aumento de massa fresca da parte aérea significativos entre os tratamentos de 3 e 4 minutos relação ao grupo controle. Porém, nenhuma alteração significativa foi percebida para massa seca. Tal fato sugeri alteração do grau de absorção de água, sendo necessários mais estudos empregando outros parâmetros.
EFEITOS DA INGESTÃO DE ÓLEO DE PEIXE PARA A SAÚDE DA POPULAÇÃO
Authors: Da Silva Abigail Gonçalves , Pereira Alencar Morramulo Emanoel , Fortunato Ruiz Rodriguez Anselmo , De Freitas Lacerda Rogério
Published: May 2022

Peixes são animais consumidos por diferentes culturas e países no mundo, esses são extremamente ricos em diversos tipos de nutrientes, como vitamina A, vitamina B12, iodo, zinco, selênio, fósforo e vitamina B2, além dessas destaca-se os Ácidos graxos, principalmente poli insaturados Ecosapentaenóico (EPA) e docosahexaenóico (DHA), sendo consumida principalmente na forma de óleos, considerado excelente fonte destas substâncias. Tem se estabelecido um consenso mundial na razão de ácidos graxos ômega 6 e ômega 3, que variam de 4:1 até 5:1, devido sua ação cardioprotetora, envolvendo prevenção à fibrilação atrial, aterosclerose, trombose e morte cardíaca súbita. Além de melhorias nas funções cognitivas, de aprendizagem e memória, presentes desde a formação do Sistema Nervoso Central, diminuindo fatores associados aos processos neurodegenerativos. Portanto, nesta revisão, abordaremos os principais efeitos da ingestão de óleo de peixe para a saúde da população, com ênfase especial nos benefícios do consumo de ácidos graxos principalmente ômega 3 e ômega 6. Discutiremos seus benefícios à memória, cognição e sistema cardiovascular. Esperamos com isso, elucidar que a inclusão desses derivados do peixe na dieta pode ser vista como promissora frente à prevenção de doenças neurodegenerativas, cardiovasculares e inflamatórias, bem como para a manutenção da vida saudável.
Perfectionist Preferentism
Authors: Bruckner Donald W.
Published: May 2022

This paper is about two seemingly inconsistent theories of well-being and how to reconcile them. The first theory is perfectionism, the view that the good of a human is determined by human nature. The second theory is preferentism, the view that the good of a human lies in the satisfaction of her preferences. I begin by sketching the theories and then developing an objection against each from the standpoint of the other. I then develop a version of each theory that is meant to address the objection from the other theory. It turns out that these modified perfectionist and preferentist theories are mutually supporting and co-extensive. They can be combined into a new theory, perfectionist preferentism, which is an independently plausible theory of well-being.
Does Knowledge Intellectualism Have a Gettier Problem?
Authors: Harris Keith Raymond
Published: May 2022

Knowledge intellectualism is the view that knowledge-how requires propositional knowledge. Knowledge intellectualism has a Gettier problem, or so many of its critics allege. The essence of this problem is that knowledge-how is compatible with epistemic luck in a way that ordinary propositional knowledge is not. Hence, knowledge-how can allegedly be had in the absence of knowledge-that, a fact inconsistent with knowledge intellectualism.

This paper develops two responses to this challenge to knowledge intellectualism. First, it is not clear that propositional knowledge is incompatible with the forms of epistemic luck with which knowledge-how is allegedly compatible. Second, existing cases intended to serve as counterexamples to knowledge intellectualism are flawed, and revised versions of these cases no longer elicit the judgments necessary to challenge knowledge intellectualism.
Accuracy Across Doxastic Attitudes: Recent Work on the Accuracy of Belief
Authors: Siscoe Robert Weston
Published: May 2022

James Joyce's article “A Nonpragmatic Vindication of Probabilism” introduced an approach to arguing for credal norms by appealing to the epistemic value of accuracy. The central thought was that credences ought to accurately represent the world, a guiding thought that has gone on to generate an entire research paradigm on the rationality of credences. Recently, a number of epistemologists have begun to apply this same thought to full beliefs, attempting to explain and argue for norms of belief in terms of epistemic value. This paper examines these recent attempts, showing how they interact with work on the accuracy of credences. It then examines how differing judgments about epistemic value give rise to distinct rational requirements for belief, concluding by considering some of the fundamental questions and issues yet to be fully explored.
L’autonomia decisionale della persona nelle situazioni di vulnerabilità, di debolezza e di razionalità limitata: iniziali riflessioni a margine della sentenza n. 50 del 15 febbraio 2022 della Corte costituzionale
Authors: Cembriani Fabio , Cingolani Mariano , Fedeli Piergiorgio
Published: May 2022

SOMMARIO: 1. Introduzione - 2. L’iter procedurale del giudizio di ammissibilità costituzionale dei referendum abrogativi - 3. La sentenza della Corte costituzionale che ha dichiarato non ammissibile il referendum abrogativo sull’art. 579 c.p. (‘Omicidio del consenziente’) - 4. Le buone ragioni della prudente decisione assunta dai Giudici costituzionali - 5. Conclusioni.

Decision-making autonomy of the person in situations of vulnerability, weakness and limited rationality: initial reflections on the sidelines of sentence no. 50 of 15 February 2022 of the Constitutional Court

ABSTRACT: The Authors, starting with the decision of the Italian Constitutional Court which found the referendum to abrogate art. 579 c.p. (Murder of the consenting party), address, in a practical perspective, the question of the decision-making autonomy of the person in situations of vulnerability, weakness and limited rationality. Of the referendum question, they underline its cloudiness and ambivalence before analyzing the strengths of the decision that has finally given prominence to the many situations of fragility and vulnerability of the person not always and only due to the existence of an infirmity of mind. With all the practical consequences that derive from it for the care professionals to whom these people ask not only respect but rigorous guarantees of public protection.
DANIAN (SBZ2) LARGER FORAMINIFERA FROM THE BECIRMAN FORMATION (SOUTHEASTERN TURKEY) AS EVIDENCE OF ROTALIIDS DIVERSITY IN LOWER PALEOCENE SHALLOW-WATER ENVIRONMENTS
Authors: SINANOĞLU DERYA , BENEDETTI ANDREA , ÖZGEN-ERDEM NAZIRE
Published: May 2022

An important shallow marine deposit is described and illustrated with focus on the systematics and biostratigraphy of larger foraminifera from three stratigraphic sections of the Becirman Formation from the Batman and Siirt regions (Southeastern Turkey). A quite diverse association, mostly dominated by rotaliids (11 species belonging to 7 genera) and subordinate porcelaneous and agglutinated taxa, is documented as well. The fossil assemblage, including Elazigina dienii, Rotospirella conica, Praelockhartia cf. neoakbari, Cuvillierina cf. sireli associated with Mardinella daviesi and Idalina sinjarica, indicates the late Danian SBZ2.
The abundance of rotaliids is linked, in this time frame, to the recovery of the shallow benthic communities after the K/Pg extinction including increase of surface water temperatures and oligotrophy. This was possibly due to the climatic warming recorded at the end of the Danian (Latest Danian Event), thus promoting a rapid adaptative radiation of rotaliids at genus rank.
THE TUROLIAN HIPPARIONS FROM CIOBURCIU SITE (REPUBLIC OF MOLDOVA): SYSTEMATICS AND PALEODIET
Authors: RĂŢOI BOGDAN G. , HAIDUC BOGDAN S. , SEMPREBON GINA M. , ŢIBULEAC PAUL , BERNOR RAYMOND L.
Published: May 2022

The Cioburciu hipparions, Republic of Moldova, are included in a Turolian assemblage, approximately dated between 9 and 7 million years. We assess herein their taxonomic position, systematics, biogeography and paleodietary habits. We have undertaken standard equid measurements as well as accessing the Vera Eisenmann website for measurements and images and analysed craniodental and postcranial elements. This assemblage has been determined to be of a medium-sized hipparion with an elongated muzzle, well developed preorbital fossa that is dorsoventrally extensive and placed close to the orbit, lacking a caninus fossa and having a prominent and deep buccinator fossa. As such, this assemblage is referable to Cremohipparion moldavicum Gromova 1952 common to the Western Ukraine, Balkans, Romania, Republic of Georgia, Turkey and Iran. We have employed a combination of gross cheek tooth wear morphology utilizing the mesowear method and a microscopic analysis of occlusal enamel scars utilizing the light microscope microwear technique. These complementary paleodietary methods indicate that these hipparions engaged in a mixed feeding dietary behavior and that the Cioburciu sample of C. moldavicum likely alternated its diet between browsing and grazing seasonally and/or regionally. A hierarchical cluster analysis based on average scratch and pit numbers positions this taxon among extant mixed feeding ungulates. Large pitting and gouging assessed through the microwear technique indicates occasional consumption of relatively coarser foods than typical mixed feeders or grazers or grit-laden food just prior to death while mesowear indicates that this was not a lifetime habit.
COVID 19 AND SPONTANEOUS PNEUMOTHORAX, RETROSPECTIVE CASE SERIES
Authors: PERVAIZ R , BIBI T , ARIF B , MUNAWAR A , SITARA R , QAYYUM MA , RAZA A , SHAHPER A , HAFEEZ MM
Published: May 2022

COVID-19 Sars Co V2 or Corona Virus disease is a highly infectious multisystem disease with severe acute lung injury leading to ARDS and respiratory failure as its main complication. Spontaneous pneumothorax is a complication which is though uncommon but could be life threatening and hence carries poor prognosis. We hereby describe a series of six cases of spontaneous pneumothorax which were seen in Bahria International Hospital COVID management unit during last 3 months of COVID-19 surge in Lahore These cases indicate that multiple factors are associated with development of spontaneous pneumothorax in COVID-19 pneumonia patients but main role is played by the increased inflammatory response and can be regarded as a potential underlying mechanism of pneumothorax in such patients, leading to acute decompensation and worsening of respiratory failure and poor outcome.
Proximicin A-C as prospective HER2-positive and negative breast cancer drugs: Molecular docking and in silico ADME modeling
Authors:   Marine Pharmacology, Ocean College, Zhejiang University, China, Aung Thet Htwe
Published: May 2022

Breast cancer is the second leading cause of cancer-related death among women worldwide. Proximicin A-C are bioactive chemicals produced by the marine Verrucosispora strain, which have been shown to have potent cytostatic effect against human breast cancer [MCF 7]. HER2 (Human epidermal growth factor receptor 2) is a gene that has been linked to breast cancer development. The study’s goals are to (1) forecast the intensity of binding affinity and interactions between HER2 and proximicin A-C, and (2) analyze ADME characteristics of proximicin A-C (Absorption, Distribution, Metabolism, and Excretion). The CB-Dock web service was used to dock proximicin A-C and commonly used breast cancer medicines Neratinib (Nerlynx) and Talazoparib against HER2, and protein-ligand interaction findings were collected via the protein-ligand interaction profiler (PLP) web server. The SwissADME web server was used to investigate ADME properties of the substances. In terms of docking, proximicin A has a vina score of -8.6, proximicin B and C has a score of -10, Talazoparib has a vina score of -8.5, and Neratinib (Nerlynx) has a vina score of -10.2 on CB-Dock. This means that proximicin B and C bind to HER2 more strongly than proximicin A and Talazoparib. Furthermore, their high binding affinity is nearly equivalent to Neratinibs (Nerlynx). Talazoparib has a lower binding affinity for HER2 than proximicin A. With HER2, all three chemicals have a strong hydrogen bond and hydrophobic contact. SwissADME estimated that all three substances follow the Lipinski rule (RO5) and have a bioavailability score of 0.55. They don’t have any structural issue in medicinal chemistry (no alerts in PAINS and Brenk forecasts), and their synthetic accessibility scales range from 3 to 3.5. Only proximicin A, on the other hand, has the leadlikeness feature. All three drugs failed to cross the blood-brain barrier (BBB) in terms of pharmacokinetics. Proximicin A has a high absorption rate in the GI tract, whereas proximicin B-C has a low absorption rate in the GI tract (GI). Similarly, proximicin A is neither a P-gp substrate nor a CYP1A2, CYP2C19, CYP2C9, CYP2D6, or CYP3A4 inhibitor. Proximicin B-C, on the other hand, are P-gp substrates, and proximicin C is an inhibitor of all provided CYP enzymes, whilst proximicin B inhibits only three. Overall, proximicin A-C could be used as a possible breast cancer therapeutic candidate. Proximicin B-C will outperform proximicin A in terms of therapeutic efficacy. Proximicin A, on the other hand, will have better ADME qualities than Proximicin B-C. This study will provide the lead information for developing a new breast cancer medication with a good pharmacological profile.
Twin seedlings in Symplocos Kanarana Talb.
Authors: Gunaga Rajesh , Vasudeva R.
Published: May 2022

Symplocos kanarana Talbot (Family: Symplocaceae) is an evergreen tree species of the Western Ghats. During the nursery study, three twin seedlings of S. kanarana are recorded and it contributed 5% abnormality to the entire seedling lot.
Note on the distribution of Ceropegia bulbosa var. lushii (Apocynaceae) in Andhra Pradesh
Authors: Ramana Munigela , Rao V. , Rao V.
Published: May 2022

Ceropegia bulbosa var. lushii, reported by Roxburgh (1795) from Andhra Pradesh is collected recently from Greater Hyderabad. The species is described and discussed its distribution in Andhra Pradesh.
Pteridophytes of Budha Kedar and surrounding areas in Tehri district of Uttarakhand
Authors: Joshi Pushpesh , Kumar Brijesh , Kumar Ramesh , Pande H.
Published: May 2022

The paper deals with the Pteridophytes of Budha Kedar and surrounding areas in Tehri District. A total of 66 species under 33 genera and 20 families from the area are being reported in the present communication.
A climatological study of severe Heat Waves in India
Authors: RAGHAVAN K.
Published: May 2022

Results of a climatological study of severe heat waves in India based on observations extending over a period of 51 years are presented, Their period of occurrence, frequency, intensity, persistency, extent, development and decay are discussed with the help of 4 diagrams and 7 tables.
Pengaruh Model Brain Based Learning berbantuan LKPD Berbasis Mind Maps terhadap Kemampuan Koneksi Matematis Siswa SMA Negeri 1 Langsa
Authors: Srimuliati Srimuliati , Faisal Faisal , Mazlan Mazlan , Sari Batu Bara Winda
Published: May 2022

Penelitian ini menjelaskan tentang kemampuan koneksi matematis siswa dalam menyelesaikan permasalahan matematika. Penelitian ini bertujuan untuk mengetahui pengaruh model Brain based learning berbantuan LKPD yang dipadukan dengan mind maps terhadap kemampuan koneksi matematis siswa. Metode penelitian ini yaitu penelitian kuantitatif dengan desain Non-equivalent control group design. Populasi dalam penelitian ini adalah siswa kelas X SMA N 1 Langsa tahun ajaran 2019 / 2020 yang berjumlah 71 orang, yang masing-masing di pilih dengan teknik purposive sampling, baik untuk kelas eksperimen maupun kelas kontrol. Adapun yang menjadi sampel yaitu siswa kelas X Mia 1 yang berjumlah 36 siswa sebagai kelas eksperimen dan siswa kelas X Mia 2 yang berjumlah 35 siswa sebagai kelas kontrol. Metode pengambilan data menggunakan 4 butir soal uraian pada materi perbandingan trigonemetri pada segitiga siku-siku. Adapun data yang diperoleh dianalisis menggunakan Uji Independet Samples Test berbantuan SPSS 17. Hasil penelitian menunjukkan bahwa diperoleh nilai t sebesar 2,057 dengan sig (2-tailed) 0,043. Maka secara signifikan dapat disimpulkan bahwa terdapat pengaruh Model Brain based learning berbantuan LKPD berbasis mind maps terhadap kemampuan koneksi matematis siswa di SMA Negeri 1 Langsa.
“Remédio Amargo”: Caso de Ensino Sobre o Dark Side da Indústria Farmacêutica
Authors: Franqueiro Nathália Santos , Lima Ana Flávia Martins de , Oliveira Cintia Rodrigues de
Published: May 2022

Visando estimular o debate e o pensamento crítico dos estudantes da área de gestão e negócios, este caso de ensino tem como objetivo apresentar uma situação real em que são evidenciadas condutas e práticas inadequadas, imorais e criminosas cometidas por uma empresa do ramo farmacêutico. Portanto, difere de outros cujo interesse seja identificar melhores práticas e tomada de decisão para determinada situação gerencial. O caso em evidência é o episódio “Remédio Amargo”, da série não ficcional “Na Rota do Dinheiro Sujo”, que apresenta as diversas práticas ilegais e imorais cometidas pela empresa farmacêutica Valeant, na tentativa de obter maiores lucros e retornos para seus acionistas. Este caso possui como enfoque as práticas corporativas prejudiciais à sociedade e que oportuniza o debate sobre as consequências dessas ações e como essas podem ser evitadas.
Bishop John Leonard Wilson (Singapore 1941-1949): Koinonia in Suffering
Authors: MAK Sue Ann
Published: May 2022

Despite a century of ecumenical efforts among Protestant churches, real koinonia remains as elusive as ever. This article introduces John Leonard Wilson, one of the early contributors to the formation of Trinity College (known today as Trinity Theological College) in Singapore, to emphasize his ecumenical spirit that continues to be a key characteristic of the college. Leonard Wilson’s war time experiences in Singapore and its aftermath as well as those of TTC’s co-founders, show koinonia working at a much deeper level beyond the loose associations, large gatherings and joint declarations commonly seen in modern ecumenical movements. Wilson’s imprisonment and torture experiences during the war, his wider contributions before and after the war, and his devotion to church unity continue directly and indirectly to influence the Singapore church’s larger story. Wilson’s almost-fanatical commitment to and practice of koinonia in the midst of harsh circumstances has demonstrated that real koinonia is possible, but it comes with a heavy price.
STRESS AMONG HOSPITALIZED PATIENTS AT TEACHING HOSPITAL, CHITWAN
Authors: Lama Sumita , Ghimire Srijana
Published: May 2022

Background: Stress is defined as the non- specific physiologic response of the body to any demand made upon it. Stress is a state produced by a change in the environment that is perceived as a challenging, threatening or damaging to a person’s dynamic balance or equilibrium. This study tries to find out the stress among the hospitalized patients.

Methods: A descriptive, cross sectional study design was used to find out the stress among the hospitalized patients of Chitwan Medical College Teaching Hospital, Chitwan. Purposive sampling technique was used. Structured questionnaire was used to collect the data through interview method. The data was edited, coded and analyzed using statistical package of social sciences (SPSS) version 16.0. Descriptive and inferential statistics was used to analyze the data.

Results: Out of 84 respondents, 52.4% respondents were female. Findings of the study revealed that more than half of the respondents 57.1% had high stress. So this study showed that the patients had high level of stress during hospitalization. The result also showed that there was statistically significant association between level of stress and sex of the respondents (p=0.002), educational status (p=0.002), place of residence (p=0.01), sufficiency of family income (0.02), previous experience of hospitalization (p=0.03). The major stressors identified in this study were economic stressors, stressors related to family role, disease condition. The minor causing stressors were stressors related to professional behaviors of health personnel and hospital related stressors.

Conclusions: Stress reduction activities such as counseling, warm environment should be provided for the patients to enhance the quality of life by reducing stress.