bluuebunny/crossref_metadata_2025 huggingface dataset:
Micro-organismos endofíticos e níveis de nitrogênio no crescimento de plantas de arroz
Authors: Gois Larissa de Souza , Santos Jessica Silva , Santos Jacilene Francisca Souza , Barbosa Andrea Verônica Gobbi , Viégas Pedro Roberto Almeida , Marino Regina Helena
Published: June 2019

RESUMO Os micro-organismos endofíticos podem estimular o crescimento a depender da interação com a planta hospedeira e da disponibilidade de nutrientes no solo. O objetivo deste trabalho foi avaliar o crescimento de plantas de arroz BRS Tropical cultivadas com fungos endofíticos e níveis de adubo nitrogenado em estufa agrícola. O delineamento experimental utilizado foi inteiramente ao acaso no esquema fatorial de 4 x 4, correspondentes a quatro tratamentos (controle - sem inóculo fúngico e três isolados micorrízicos: UFLA351 - Rhizoglomus clarum, UFLA372 - Claroideoglomus etunicatum e UFLA401 - Acaulospora morrowiae) e quatro níveis de ureia (0, 100, 300 e 600 mg Kg-1 de N) com quatro repeticões. O arroz BRS Tropical foi colonizado por fungos micorrízicos arbusculares (FMA) e por fungos endofíticos “dark septate” (DSE). A adubação nitrogenada à base de ureia não influenciou na colonização por isolados UFLAs e por fungos endofíticos DSE em plantas de arroz. A adubação nitrogenada inibiu a formação de hifas, mas não a produção de vesículas e de arbúsculos dos isoladods UFLAs. A esporulação micorrízica foi inibida por adubação nitrogenada, a depender do isolado fúngico. No controle, sem FMA, a colonização das plantas de arroz por fungos endofíticos DSE foi inibida pela adubação nitrogenada. Os fungos endofíticos DSE não interferiram na colonização micorrízica pelos isolados UFLAs. As plantas de arroz BRS Tropical foram responsivas a inoculação dos isolados UFLA351 e UFLA401 com 600 mg Kg-1 N. As plantas de arroz BRS Tropical cultivadas sem AMF e 600 mg Kg-1 N foram responsivas à adubação nitrogenada.
Protocol adjustment improves the extraction of high-quality total RNA from common bean stems infected by Sclerotinia sclerotiorum
Authors: Miranda Rafael Novais de , Silva Caroline Marcela da , Porto Antonio Carlos da Mota , Pereira Welison Andrade
Published: June 2019

ABSTRACT The Straw Test is an assay developed to evaluate the resistance of common bean to white mold, in which the plant stems are inoculated and the symptoms of the disease are monitored. It is plausible to admit that investigating gene expression in pathogen-infected tissues may be strategically interesting. However, obtaining a quality RNA is a basic requirement for this purpose. Therefore, the objective of this study was to evaluate adjustments in protocols of commercial kits in the expectation of improving the quality of RNA obtained from bean stems. For this, plants of two lines were inoculated and the stems pathogen-infected were collected 72 hours after. For RNA extraction, two commercial reagents were used following the manufacturer’s recommendations and then following adaptations in these protocols. In particular, the proposed modifications relate to volumes of supernatant recovered in purification steps, additional step of chloroform purification and extended time for nucleic acids precipitation. The obtained RNA was analyzed by spectrophotometer, electrophoresis and bioanalyzer, then converted into cDNA and subsequently submitted to PCR. From the obtained data, it was observed that the adaptations made in the protocols contributed to better results and that, when the indicative values of RNA quality are guaranteed, the subsequent reactions are more pure, precise and representative.
Genetic parameters and combined selection for phosphorus, phytate, iron, and zinc in Mesoamerican common bean lines
Authors: Ribeiro Nerinéia Dalfollo , Steckling Skarlet De Marco , Mezzomo Henrique Caletti , Somavilla Iuri Paulo
Published: June 2019

ABSTRACT The development of common bean cultivars that contain satisfactory minerals and phytate concentrations for the different nutritional requirements of consumers is a new strategy of breeding programs. This work aimed to obtain estimates of genetic parameters for the concentrations of phosphorus, phytate, iron, and zinc in a recombinant inbred line (RIL) population of Mesoamerican common bean, to study the correlations between these traits, and to select common bean lines for the biofortification program and for diets that require the decrease in the intake of these minerals. The RIL were obtained from the cross between BRS Esteio and SCS 205 Riqueza. Genetic variability and transgressive segregation were detected for all traits evaluated. Heritability estimates for the concentrations of phosphorus, phytate, iron, and zinc ranged from intermediate (h2: 30.31%) to high (h2: 98.68%) magnitude, and quantitative inheritance was observed. The phosphorus concentration showed an intermediate correlation estimate with iron (r = 0.4157) and zinc (r = 0.5693) concentrations. Cultivar BRS Expedito and line L 56-17 have a low phytate concentration (≤ 1.29%) and a high iron concentration (≥ 95 mg kg-1 of dry matter - DM), and will be selected by the common bean biofortification program. Lines L 59-17, L 31-17, and L 26-17 and cultivars IPR Siriri and BRS Valente have a high phytate concentration (≥ 2.57%) and a low zinc concentration (≤ 26 mg kg-1 DM) and will be selected for diets that aim at using the beneficial properties of phytate and reducing the zinc intake.
Aspects of mating behavior and antennal sensilla in Anomala inconstans Burmeister, 1844 (Coleoptera: Scarabaeidae: Rutelinae)
Authors: Rodrigues Sérgio Roberto , Fuhrmann Juares , Amaro Ricardo Aparecido
Published: June 2019

Abstract: When suitable, adults of Scarabaeidae usually form swarms to find food and breeding sites. The steps of mating behavior can be mediated by chemical communication, and antennal sensilla are released volatiles detection structures, as sexual pheromones. In present work the mating behavior and the antennal sensilla of Anomala inconstans Burmeister, 1844 are described. The study was conducted at the Universidade Estadual de Mato Grosso do Sul, Cassilândia, Brazil from March 2015 to December 2017. Adults were collected through a light trap and taken to the laboratory for studies. Field and laboratory observations provided data for the description of the steps of mating behavior. Adults swarms were registered from September to November 2015 at 05:30 pm to 00:00 am. Females display a calling behavior from 05:25 pm to 08:00 pm, in which they rub their posterior legs against their abdomen, and after a few minutes males are able to locate them. In laboratory, the mating process lasted 20.4 minutes on average, and the possibility of chemical communication between adults was here discussed. The antennae of the species have trichoid, chaetica, placoid types I, II and III, and coeloconic types I and II sensilla. Placoid sensilla are the most abundant and females have more sensilla than males.
Acquisition of family farm foods in municipalities of São Paulo state: The influence of the management of the School Feeding Program and municipal characteristics
Authors: SOUZA Vanessa Manfre Garcia de , VILLAR Betzabeth Slater
Published: June 2019

ABSTRACT Objective To describe and analyze the implementation aspects of the purchase of food from family farms, according to the management of the School Feeding Program and characteristics of municipalities in the state of São Paulo. Methods A cross-sectional descriptive-analytical study, including 25 municipalities from São Paulo that purchased from family farms for school feeding, where 105 schools were drawn, in 2013, to verify: knowledge of the Law No.11,947/2009, disclosure of the purchasing process, guidance on the management of food, kitchen improvements, variety of food purchased and the use ≤30% of the Program’s resources with family farming. Absolute and relative frequencies were analyzed, and Chi-square test and Fisher’s exact test were performed (p<0.05). Results The knowledge of Law No.11,947/2009 predominated in centralized management (p=0.010) and the disclosure of the purchasing process in school/mixed management (p=0.010); all municipalities of school/mixed management used ?30% of resources (p=0.015). The disclosure of the purchasing process was more frequent in municipalities with fewer students (p=0.038) and lower Gross Domestic Product (p=0.020); guidance on food management was more frequent in smaller municipalities (p=0.011), with fewer public schools (p=0.040) and lower Gross Domestic Product (p=0.003); the variety of foods was more frequent in smaller municipalities (p=0.027), with fewer students (p=0.025), smaller area (p=0.025) and medium Human Development Index (p=0.001). Conclusion The management of the School Feeding Program and municipal factors can influence the implementation of the purchase of food from family farms.
Improvement in dietary intake estimates through the combined use of different approaches
Authors: LOPES Raíssa do Vale Cardoso , TEIXEIRA Juliana Araújo , MARCHIONI Dirce Maria , VILLA Luisa Lina , GIULIANO Anna Regina , FISBERG Regina Mara
Published: June 2019

ABSTRACT Objective This study aimed to compare dietary intake estimates using two different methodological approaches: use of new portions obtained with the 24-Hour Diet Recall, which was applied in the current study population, and the application of calibration equations, which were estimated using the same 24h-recalls. Methods Calibration equations were estimated using linear regression. The medians and confidence intervals of energy and nutrient intakes were assessed using all the approaches. The U Mann Whitney test was applied to verify differences among dietary intakes obtained with the 24 Hour Recall and Food Frequency Questionnaire-based methods. The correlation between different measures was assessed with Spearman coefficient. Weighted Kappa was used to verify the capability of the Food Frequency Questionnaire -based methods to classify individuals in the same intake levels of the 24 Hour Recall. Results Nine of the eleven components that were analyzed using the Food Frequency Questionnaire with standard portions and calibrated had medians significantly different from those obtained using the 24 Hour Recall; only the measurements of vitamin E and energy were statistically equal. For the Food Frequency Questionnaire with 24 Hour Recall portions, only the medians of vitamin D and B12 did not significantly differ from the 24 Hour Recall medians. Finally, for the Food Frequency Questionnaire with 24 Hour Recall portions and calibrated, all components, except folate and iron, had medians statistically equal to those obtained using the 24 Hour Recall. Spearman correlation coefficients were higher for the Food Frequency Questionnaire with 24 Hour Recall portions calibrated for all the assessed components, and the values ranged from 0.27 (total fat) to 0.57 (iron). Higher Kappa correlation coefficients were found for the Food Frequency Questionnaire 24 Hour Recall portions calibrated. Conclusion Calibrated FFQ with portions estimated from the own target population obtained better estimates of dietary intake, with values considerably more similar to those obtained with the reference method.
Molecular profile of non-small cell lung cancer in northeastern Brazil
Authors: Oliveira Ana Claudia da Silva Mendes de , Silva Antonio Vinicios Alves da , Alves Marclesson , Cronemberger Eduardo , Carneiro Benedito Arruda , Melo Juliana Carneiro , Martins Neto Francisco , Tavora Fabio
Published: June 2019

ABSTRACT Objective: To investigate the histological subtypes and mutational profiles of non-small cell lung cancer in Brazil, looking for correlations among histological subtypes, expression of anaplastic lymphoma kinase (ALK), EGFR mutation status, and programmed death-ligand 1 (PD-L1) expression. Methods: We evaluated 173 specimens obtained from patients with lung adenocarcinoma in northeastern Brazil. Expression of PD-L1 and ALK was evaluated by immunohistochemistry; EGFR mutation status was evaluated by sequencing. We categorized the histological subtypes in accordance with the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification. Results: The most common histological subtypes of lung adenocarcinoma were solid predominant (in 46.8%), acinar predominant (in 37.0%), and lepidic predominant (in 9.8%). ALK expression was detected in 10.4% of the samples, and 22.0% of the tumors harbored EGFR mutations. The most common EGFR mutation was an exon 21 L858R point mutation (in 45.5%), followed by an exon 19 deletion (in 36.3%). The tumor proportion score for PD-L1 expression was ≥ 50% in 18.2% of the samples, 1-49% in 32.7%, and 0% in 49.5%. The solid predominant subtype was significantly associated with wild-type EGFR status (p = 0.047). Positivity for PD-L1 expression was not found to be significantly associated with ALK expression or EGFR mutation status. Conclusions: Our results suggest that the molecular profile of non-small cell lung cancer in northeastern Brazil differs from those of populations in other regions of the country, with ALK positivity being higher than the other biomarkers. Further studies including clinical and genetic information are required to confirm these differences, as well as studies focusing on populations living in different areas of the country.
Effects of psychological problems on surgical outcomes
Authors: Laurino Neto Rafael Melillo , Herbella Fernando A. M.
Published: June 2019

SUMMARY Surgeons are becoming aware that surgical outcomes are not only based on technical skills. The impact of psychological problems on outcomes must be studied from both the patient's and the health care provider's viewpoint. Psychological problems may affect up to 20% of the population, with almost half of them non-treated. Surgeons have to deal with a significant number of patients with psychological problems, which affect surgical outcomes changing how symptoms, results and side effects are interpreted. Surgeons also face psychological problems at a significant rate. Although there are no studies on the effect of chronic psychological problems of the surgeon on outcomes, in simulated scenarios, acute stress usually leads to worse performance. Some initiatives can be implemented to improve outcomes based on the effect of psychological problems.
The role of endoscopic ultrasound in the staging of tracheal neoplasm: a brief review
Authors: Oliveira Cristiane Mota , Colaiácovo Rogerio , Araki Osvaldo , Domene Anna Fernanda Cazavia , Mamede Filho Divino Oliveira , Saieg Mauro Ajaj , Rossini Lucio Giovanni Battista
Published: June 2019

SUMMARY Our case report shows the complexity of dealing with tracheal tumors, highlighting the importance of the method used for staging. In this report, endoscopic ultrasound (EUS) was crucial to identify the involvement of the esophageal muscular propria in a tracheal tumor and change the surgical planning of the case. Staging this kind of tumor represents a challenge for physicians. There is no evidence in the literature on which methods represent the gold standard for T staging.
Is hepatojugular reflux a good predictor of heart failure with preserved ejection fraction?
Authors: Baldivia Guilherme Cristianini , Napoli João Vitor Moraes Pithon , Motta Josiane Motta e , Vieira Filho Normando Gomes , Lopes Heno Ferreira
Published: June 2019

SUMMARY Hypertension may occur with left ventricular (LV) diastolic dysfunction, and the consequence may be symptoms and signs of heart failure (HF). Hepatojugular reflux (HJR), described as a sign of regurgitation of the tricuspid valve, may reflect structural and functional changes of the LV in the hypertensive patient. The signal may be present in the presence of HF. Case: male, 49 years old with uncontrolled blood pressure. Physical examination showed jugular turgescence, HJR, and elevated blood pressure. Complementary exams showed signs of atrial and left ventricular overload in the electrocardiogram and, the echocardiogram showed left atrium volume increase, concentric LV hypertrophy and signs of grade I diastolic dysfunction. DISCUSSIO: The HJR present correlates with pulmonary artery pressure and probably reflect the increase in central blood volume.
Evaluation of the systemic and therapeutic repercussions caused by drug interactions in oncology patients
Authors: Monteiro Camila Ribeiro de Arruda , Schoueri Jean Henri Maselli , Cardial Debora Terra , Linhares Lívia de Castro , Turke Karine Corcione , Steuer Lia Vineyard , Menezes Levy Werneck de Almeida , Argani Igor Luiz , Sette Claudia , Cubero Daniel de Iracema Gomes , Giglio Auro del
Published: June 2019

SUMMARY INTRODUCTION: Drug interaction is an important cause of global morbidity. It is of particular importance in cancer patients since they are often in use of polypharmacy, related to interactions between the drugs and the chemotherapeutics used. OBJECTIVE: To evaluate the drug interaction between chemotherapy and other drugs in cancer patients. METHODS: a cross-sectional study carried out in the outpatient oncology department of a public tertiary hospital. Two hundred thirty-five patients were included, and the drugs they were using were identified. Using the MedScape and Epocrates database, we evaluated the interactions between medications and chemotherapy by defining their frequency and dividing their severity from interaction into mild, close monitoring necessity and severe. RESULTS: 161 patients had some drug interaction. We identified 9 types of mild interactions, 23 types of interactions with close monitoring necessity, and 2 types of serious interactions. The most frequent interactions were between fluorouracil and leucovorin (32 cases) and cyclophosphamide and doxorubicin (19 cases). Serious interactions were between aspirin and pemetrexed; and leucovorin and Bactrim. CONCLUSION: In the present study, drug interactions were frequent, including serious interactions with a potential increase in morbidity and mortality. Thus, it is necessary for oncologists to draw up a therapeutic plan considering potential interactions between prescribed chemotherapy and current medications in use by patients.
Restless legs syndrome and quality of life in pregnant women
Authors: Akbaş Pınar , Sözbir Şengül Yaman
Published: June 2019

SUMMARY OBJECTIVE: In this study, we aimed to determine the extent of restless legs syndrome (RLS) in pregnant women and evaluate the relationship between the syndrome and quality of life. METHODS: This is a cross-sectional descriptive study. A questionnaire developed by the researcher, the Short Form 36 (SF-36) Questionnaire to measure the quality of life, the International Restless Legs Syndrome Study Group (IRLSSG) Diagnostic Criteria for RLS and the Restless Legs Syndrome Rating Scale were applied to the women to collect the data. A total of 250 pregnant women were included in the study. RESULTS: The mean age of the women was 28.11 ± 5.59 years and the mean gestational time was 26.26 ± 10.72 weeks. Symptoms of RLS were seen in 46.4 % of the women. The mean for the RLS Violence Rating Score was 20.82 ± 6.61 for the women with RLS. RLS was found to be mild in 5.2 % of the women, moderate in 45.7 %, severe in 40.5 % and very severe in 8.6 %. A statistically significant effect of RLS survival on quality of life was observed. CONCLUSION: These results indicate that almost half of the pregnant women in this study experienced RLS, and about half of those with RLS experienced severe or very severe RLS. There is a significant relationship between RLS and six domains of SF-36 (physical, role limitations, pain, general health perception, energy/vitality, and mental health).
Investigation of the relationship between umbilical cord pH and intraventricular hemorrhage of infants delivered preterm
Authors: Mazouri Ali , Massahi Mahtab , Khalesi Nasrin , asl Ladan Younesi , Kashaki Mandana
Published: June 2019

SUMMARY OBJECTIVE: We measured the level of pH gases in premature infants at birth, and examined the relationship between brain ultrasonography on the third and seventh day after birth. A case-control study conducted at the Neonatal Intensive Care Unit (NICU) of Shahid Akbar Abadi Hospital, Iran, during the years 2016-2017. METHODS: All premature infants who were admitted to NICU were enrolled in the current study. At birth, a blood gas sample was taken from the umbilical cord of the infants. On the third and seventh day after birth, an ultrasound of the brain of each neonate was performed by a radiologist. The umbilical cord was evaluated for blood gases in 72 neonates (mostly boys). RESULTS: Sixty-six newborns had normal sonography, and 16.7% (12 cases) had anomalies. A total of 75% of the 8 infants with intravenous bleeding were girls, which were significantly different from those in the non-hemodynamic group (62.5% male) (P 0.049). However, the type of delivery, mean weight, height, head circumference, the circumference of the chest, and Apgar score did not differ between the two groups. Mean pH, HCO3– and PCO2 in umbilical cord blood gas samples were not significantly different between the two groups with or without intraventricular hemorrhage (IVH). Although it was not related to gender and type of delivery in newborns CONCLUSION: Blood gases do not help in determining the occurrence of IVH in infants. Nevertheless, it is associated with immaturity and fetal age.
Successful medical drainage and surgical treatment for vertebral osteomyelitis and bilateral psoas abscess with gas formation caused by klebsiella pneumoniae in a diabetic patient
Authors: Yu Wei-Yang , Zhu Ke-Jun , Li Qiao-Ping , Lou Chao , He Deng-Wei
Published: June 2019

SUMMARY OBJECTIVE: We describe the case of a diabetic patient who developed vertebral osteomyelitis and bilateral psoas abscess with gas formation due to klebsiella pneumoniae. METHODS: A 64-year-old woman with a 4-year history of type-2 diabetes mellitus was admitted to the Emergency Department. The subject had a 2-day history of high-grade fever associated with chills and a 5-hour history of consciousness. She received empirical treatment with febrifuge, after which her fever decreased. RESULTS: Her fever recurred after an interval of three hours. A computed tomography scan of the abdomen revealed vertebral osteomyelitis and bilateral psoas muscle abscess with gas formation. Blood culture and purulent fluid described the growth of the Klebsiella pneumoniae. The patient received antibiotic therapy and bilateral drainage therapy after the drainage catheter was placed into the abscess cavity by CT-guidance. Due to the serious damage to the vertebral column and permanent pain, the patient underwent minimally invasive internal spinal fixation and recovered successfully. CONCLUSION: A case of vertebral osteomyelitis and bilateral psoas abscess with gas formation caused by Klebsiella pneumoniae in a diabetic patient. Antibiotic therapy, drainage, and minimally invasive internal spinal fixation were performed, which enabled a good outcome.
Profile and scientific output of researchers recipients of CNPq productivity grant in the field of medicine
Authors: Martelli Daniella Reis , Oliveira Maria Christina Lopes , Pinheiro Sergio Veloso , Santos Maria Luiza , Dias Veronica , Silva Ana Cristina Simões e , Martelli-Júnior Hercílio , Oliveira Eduardo Araujo
Published: June 2019

SUMMARY BACKGROUND. This study aimed to evaluate the scientific production of researchers in the field of Medicine who receive a productivity grant from the CNPq. METHODS: The curriculum Lattes of 542 researchers with active grants from 2012 to 2014 were included in the analysis. Grants categories/levels were stratified into three groups according to the CNPq database (1A-B, 1C-D, and 2). RESULTS. There was a predominance of grants in category 2. During their academic career, Medicine researchers published 76512 articles, with a median of 119 articles per researcher (IQ, interquartile range, 77 to 174). Among the 76512 articles, 36584 (47.8%) were indexed in the Web of Science (WoS database). Researchers in Medicine were cited 643159 times in the WoS database, with a median of 754 citations (IQ, 356 to 1447). There were significant differences among the categories of grants concerning the number of citations in WoS (P <0.001). There was a significant difference in the number of times researchers were cited according to the specialty included in Medicine area. (P < 0.001). CONCLUSION. Strategies to improve the scientific output qualitatively possibly can be enhanced by the knowledge of the profile of researchers in the field of Medicine.
Prevalence of hypovitaminosis D in postmenopausal women: a systematic review
Authors: Valladares Tania , Simões Ricardo , Bernardo Wanderley , Schmitt Ana Carolina Basso , Cardoso Maria Regina A. , Aldrighi José Mendes
Published: June 2019

SUMMARY BACKGROUND: Hypovitaminosis D is considered a global public health issue. Knowledge of its true dimensions will allow us to design interventions and plan preventive measures that can have a significant impact on human health. OBJECTIVES: The aim of this study was to evaluate the prevalence of hypovitaminosis D, defined as a serum 25-hydroxyvitamin D concentration < 30 ng/ml, in postmenopausal women around the world, as well as to identify the potential associated factors. METHODS: A systematic review was performed in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses recommendations. Specific search terms were consulted in Medline, Excerpta Medica, and Latin-American and Caribbean Health Sciences Literature databases, with no restriction for the year or language of publication. RESULTS: Of 451 studies initially identified, 32 were selected for analysis. Collectively, those 32 studies evaluated 21,236 postmenopausal women, of whom 16,440 (77.4%) had serum 25-hydroxyvitamin D concentrations < 30 ng/ml. The reported prevalence of hypovitaminosis D ranged from 29% (in the United States) to 99.4% (in China). In six of the studies, the prevalence was above 90%. CONCLUSIONS: If the criterion is the 30 ng/ml cut-off point, the majority of postmenopausal women in the world could be classified as having hypovitaminosis D. Among the studies evaluated, the lowest prevalence reported was nearly 30%. Neither latitude, region of the world, nor laboratory methodology were found to be associated with the prevalence of hypovitaminosis D.
Repercussions of melatonin on the risk of breast cancer: a systematic review and meta-analysis
Authors: Veiga Eduardo Carvalho de Arruda , Simões Ricardo , Valenti Vitor E , Cipolla-Neto Jose , Abreu Luiz Carlos , Barros Ernane Pedro Matos , Sorpreso Isabel Cristina Esposito , Baracat Maria Candido P. , Baracat Edmund C , Soares Junior Jose Maria
Published: June 2019

SUMMARY Breast Cancer is common in women, but its etiology is not yet fully understood. Several factors may contribute to its genesis, such as genetics, lifestyle, and the environment. Melatonin may be involved in the process of breast cancer. Therefore, the aim of this study is to evaluate the influence of the levels of melatonin on breast cancer through a systematic review and meta-analysis. We performed a systematic review according to PRISMA recommendations. The primary databases MEDLINE, Embase, and Cochrane were consulted. There was no restriction on the year of publication and language. Data of systematic reviews from April 2017 to September to 2017 were analyzed. The meta-analysis was conducted using RevMan 5.3 software provided by the Cochrane Collaboration. From a total of 570 articles, 9 manuscripts were included in this review. They analy onzed women with breast cancer and control patients, of which 10% and 90% were in the reproductive period and after menopause, respectively. The lowest level of melatonin was found in approximately 55% of studies with breast cancer in post-menopause. The metanalyses of the studies demonstrated low levels of melatonin in breast cancer patients (n=963) compared with control patients (n= 1332), with a mean difference between the studies of −3.54 (CI −6.01, −1.06). Another difference found was in the comparison between smoking patients, with an average difference between 1.80 [0.97-2.63]. Our data suggest that low levels of melatonin might be a risk factor for breast cancer.
Isthmocele: an overview of diagnosis and treatment
Authors: Kremer Thaysa Guglieri , Ghiorzi Isadora Bueloni , Dibi Raquel Papandreus
Published: June 2019

SUMMARY An isthmocele, a cesarean scar defect or uterine niche, is any indentation representing myometrial discontinuity or a triangular anechoic defect in the anterior uterine wall, with the base communicating to the uterine cavity, at the site of a previous cesarean section scar. It can be classified as a small or large defect, depending on the wall thickness of the myometrial deficiency. Although usually asymptomatic, its primary symptom is abnormal or postmenstrual bleeding, and chronic pelvic pain may also occur. Infertility, placenta accrete or praevia, scar dehiscence, uterine rupture, and cesarean scar ectopic pregnancy may also appear as complications of this condition. The risk factors of isthmocele proven to date include retroflexed uterus and multiple cesarean sections. Nevertheless, factors such as a lower position of cesarean section, incomplete closure of the hysterotomy, early adhesions of the uterine wall and a genetic predisposition may also contribute to the development of a niche. As there are no definitive criteria for diagnosing an isthmocele, several imaging methods can be used to assess the integrity of the uterine wall and thus diagnose an isthmocele. However, transvaginal ultrasound and saline infusion sonohysterography emerge as specific, sensitive and cost-effective methods to diagnose isthmocele. The treatment includes clinical or surgical management, depending on the size of the defect, the presence of symptoms, the presence of secondary infertility and plans of childbearing. Surgical management includes minimally invasive approaches with sparing techniques such as hysteroscopic, laparoscopic or transvaginal procedures according to the defect size.
Efeitos do laser de diodo de alta potência e da fotobiomodulação em dentes de ratos reimplantados tardiamente
Authors: PEREIRA Flávia de Moura , SOUZA Adriana Aparecida de , CARVALHO Erica dos Santos , MELLO Isabel , RALDI Denise Pontes
Published: June 2019

Resumo Introdução A busca por protocolos efetivos para reduzir a incidência de reabsorções radiculares e favorecer a reparação do ligamento periodontal perdido ainda representa um grande desafio, tendo em vista o prognóstico desfavorável dos reimplantes dentais tardios. Objetivo Avaliar, por meio da análise histológica, os efeitos do laser de alta potência e da fotobiomodulação na ocorrência de reabsorção radicular e no reparo periodontal, em dentes reimplantados tardiamente. Material e método Foram utilizados 50 incisivos centrais direitos de ratos Wistar. Após a extração, os espécimes foram divididos em cinco grupos (n = 10): G1 (controle positivo): reimplante imediato; G2 (controle negativo): reimplante tardio (RT): espécimes mantidos em ambiente seco por 60 minutos, sem tratamento adicional; G3: RT associado ao tratamento da superfície radicular com laser diodo de alta potência (810 nm, 1.5 W); G4: RT + superfícies radiculares e feridas alveolares tratadas com fotobiomodulação (laser diodo 660 nm, 30 mW e 780 nm, 40 mW, respectivamente); G5: RT + superfícies radiculares irradiadas com laser de alta e alvéolos com fotobiomodulação, nos mesmos parâmetros que G3 e G4, respectivamente. Após 60 dias, os animais foram eutanasiados. Os espécimes foram processados para análise histológica. Resultado G3 e G5 apresentaram as menores médias de scores com relação à ocorrência de reabsorções radiculares e anquilose, quando comparados a G2 e G4 (Teste Kruskall-Wallis, p<0,05). Com relação ao reparo periodontal, todos os grupos experimentais (G3, G4 e G5) apresentaram médias de escores inferiores (Teste Kruskall-Wallis, p<0,05) comparadas ao G1 e semelhantes ao G2 (Teste Kruskall-Wallis, p>0,05). Conclusão O laser de alta potência, associado ou não à fotobiomodulação, diminuiu a ocorrência das reabsorções radiculares e da anquilose, e a fotobiomodulação não favoreceu o controle das reabsorções radiculares nem o reparo periodontal.
Brazilian Congress on Speech, Language and Hearing Sciences: history, organization and scientific production
Authors: Seno Marília Piazzi , Capellini Simone Aparecida
Published: June 2019

ABSTRACT Objective: to present the history of the Brazilian Speech Therapy and Audiology Congress, exposing its organization and characterizing part of the scientific production published in its annals in the last ten years. Methods: a theoretical, descriptive-exploratory study, with a bibliographic data source. The analysis was based on data available on the website of the Brazilian Society of Speech Therapy and Audiology, and restricted to the last ten years. The findings considered the year of publication, the publication category and the study area. The statistical analysis applied the Statistical Package for Social Sciences. Results: since 2006 eleven specialties have been recognized. The areas available for submitting papers changed between 2008 and 2011. From 2012 to 2017, 7,296 participants and 5,166 publications were identified. A decrease in both publications and participants is seen since 2014. In 2017, the number of papers was higher than the number of participants. Submissions in the "thesis/dissertation" category increased by 110%. Papers of a specific field related to the human voice presented the highest number of papers in the period. Conclusion: the increase in the number of specialists, added to technological advances, may partially justify a reduction in the number of participants; however, new relocations are necessary as a way to keep the event up to date and attractive, in face of the profession’s new trends.
Accessibility of people with disabilities to higher education: social attitudes of students and professors of a higher education institution
Authors: Brunhara Jane Assunção , Berberian Ana Paula , Guarinello Ana Cristina , Biscouto Angela Regina , Krüger Simone , Silva Daniel Vieira da , Ferla Josiane Bernart da Silva
Published: June 2019

ABSTRACT Purpose: to compare and analyze social attitudes of students and professors of a higher education institution about the inclusion of people with disabilities according to variables gender, age and areas of knowledge of participants. Methods: the quantitative study was conducted on 601 academics, 583 being students and 18 university professors from a private university, who have contact with individuals with disabilities in the classroom. A questionnaire was applied to identify the social attitudes related to the variables correlated above. Results: the sample included 97% of students, 417 being females and 184 males. Nearly 43% were younger than 20 years and 6% older than 40 years. The female professors and students had higher agreement with the questionnaire, while male professors and students reported lower satisfaction. Concerning age, the younger individuals were the most dissatisfied ones. In relation to the field of knowledge, the Exact, Human and Health Sciences, in this order, presented increased agreement with the research instrument. Conclusion: the study investigated the social attitudes of professors and students about the inclusion of people with disabilities, analyzing the results according to gender, age and area of knowledge, comparing and correlating with the agreement about the questionnaire. The results revealed the need to deepen the studies about variables that may influence the social attitudes related to the inclusion and permanence of these individuals in higher education institutions.
Prevalence of temporomandibular joint disorder in people with Parkinson’s disease in a public university hospital
Authors: Silva Renato Mariano da , Santos Vilma Lucia dos , Silva Taysa Vannoska de Almeida , Lins Carla Cabral dos Santos Accioly
Published: June 2019

ABSTRACT Objective: to evaluate the prevalence of temporomandibular joint disorder in people with Parkinson’s disease in a public university hospital, and relate it to sociodemographic factors, general health and oral health self-report, and phase and time of illness. Methods: the Research Diagnostic Criteria for Temporomandibular Disorders were used. The sample was classified according to the diagnosis of temporomandibular disorder and associated with the variables. The odds ratio of Chi-square was applied with a 95% confidence interval and a level of significance set at p<0.05. Results: 110 people presented with Parkinson's disease were assessed. The prevalence of temporomandibular disorder was 35%, being more frequent among males (58%), in elderly people (53%), in phase 2 of the disease (61%), click (37%) being the predominant clinical indication. Of the variables analyzed, only gender and self-perception of oral health showed to be associated with temporomandibular disorders. Conclusion: the presence of temporomandibular disorder has been observed in people with Parkinson's disease, and the fact of being male and reporting moderate oral health seen as associated factors.
DERMATOSES IN THE EARLY NEONATAL PERIOD: THEIR ASSOCIATION WITH NEONATAL, OBSTETRIC AND DEMOGRAPHIC VARIABLES
Authors: Krüger Elisa Maria Michels , Sinkos Fernanda , Uhry Julia Feldmann , Boni Julio Cesar Bezerra De , Okamoto Cristina Terumi , Purin Kátia Sheylla Malta , Nisihara Renato
Published: June 2019

ABSTRACT Objective: To evaluate the prevalence of neonatal dermatoses in the early neonatal period and to associate them with neonatal, demographic and obstetric variables. Methods: A cross-sectional study with neonates and their respective mothers, who were hospitalized in a public maternity hospital in Curitiba, PR, Brazil. Data collection was performed using information present in the medical records and a physical examination of the newborn during the period between April 2015 and May 2016. Results: 350 neonates were evaluated. 54.8% were male, and 94.8% (332/350) presented a dermatosis. Among them, 84.6% had, concomitantly, two or more dermatoses. A total of 23 types of dermatoses were diagnosed. The most prevalent were: sebaceous hyperplasia (66%); fluff (42.6%); and salmon patches (41.4%). The mean age of the mothers was 24.9±4.9 years old, and they were predominately white (57.7%). Vernix caseosa was associated with the female gender (p=0.034). Nonwhite mothers were associated with genital hyperpigmentation (p=0.03) and Mongolian spots (p=0.001). Physiological flaking was associated with cesarean deliveries (p=0.03) and a gestational age of over 40 weeks (p=0.054). Salmon patches was associated with primiparity (p=0.0001). Conclusions: There was a high prevalence of neonatal dermatosis in the studied population. Each newborn had, on average, three different dermatoses. Dermatosis in neonates was associated with primiparity, nonwhites, a gestational age of over 40 weeks, and the sex of the newborn.
IBUPROFEN-INDUCED ASEPTIC MENINGITIS: A CASE REPORT
Authors: Pires Sofia Alexandra Pereira , Lemos Ana Pereira , Pereira Ester Preciosa Maio Nunes , Maia Paulo Alexandre da Silva Vilar , Agro João Patrício de Sousa e Alvim Bismarck do
Published: June 2019

ABSTRACT Objective: To report a case of a male adolescent with the diagnosis of ibuprofen-induced meningitis. We discuss themain causes of drug-induced aseptic meningitis (DIAM) and highlight the importance of early recognition of DIAM, sothat the offending drug can be withdrawn, and recurrences prevented. Only few DIAM cases have been reported in pediatric age. Case description: A healthy 15-year-old boy presented to the emergency department with headache, nausea, dizziness, fever, conjunctival hyperemia and blurred vision 30 minutes after ibuprofen-intake. During his stay, he developed emesis and neck stiffness. Cerebrospinal ﬂuid analysis excluded infectious causes, and DIAM was considered. He totally recovered after drug withdrawal. Comments: DIAM is a rare entity, that should be considered in the differential diagnosis of an aseptic meningitis. The major causative agents are nonsteroidal anti-inflammatory drugs, particularly ibuprofen. Suspicion is made by the chronologic link between drug intake and the beginning of symptoms, but infectious causes should always be ruled out.
A RECURRENT MUTATION IN TSHB GENE UNDERLYING CENTRAL CONGENITAL HYPOTHYROIDISM UNDETECTABLE IN NEONATAL SCREENING
Authors: Borges Maria de Fátima , Domené Horacio Mario , Scaglia Paula Alejandra , Lara Beatriz Hallal Jorge , Palhares Heloísa Marcelina da Cunha , Santos Andréia Vasconcelos Aguiar , Gonçalves Amanda Lacerda Ferreira , Oliveira Marília Matos , Marqui Alessandra Bernadete Trovó de
Published: June 2019

ABSTRACT Objective: To describe the case of a patient with central congenital hypothyroidism (CCH) due to a recurrent mutation in the TSHB gene, as well as to conduct a genetic study of his family. Case description: It is presented a case report of a 5-month-old boy with a delayed diagnosis of isolated CCH in whom the molecular analysis was performed 12 years later and detected a recurrent mutation (c.373delT) in TSHB gene. The parents and sister were carriers of the mutant allele. Comments: The c.373delT mutation has previously been reported in patients from Brazil, Germany, Belgium, United States, Switzerland, Argentina, France, Portugal, United Kingdom and Ireland. In summary, our case and other ones reported in the literature support the theory that this mutation may be a common cause of isolated TSH deficiency. Isolated TSH deficiency is not detected by routine TSH-based neonatal screening, representing a clinical challenge. Therefore, when possible, molecular genetic study is indicated. Identification of affected and carriers allows the diagnosis, treatment and adequate genetic counseling.
Politizando as escalas urbanas: jurisdição, território e governança no Estatuto da Metrópole
Authors: Hoshino Thiago de Azevedo Pinheiro , Moura Rosa
Published: June 2019

Resumo O Estatuto da Metrópole (lei n. 13.089/2015) é objeto de análise exploratória neste artigo. O diploma tem potencial para promover uma reconfiguração político-jurídica nos sentidos da governança interfederativa. Por isso mesmo, mobiliza atores assimétricos que disputam o reescalonamento da política urbana. Tanto assim que o Estatuto já sofreu substanciais supressões quanto aos prazos para adequação institucional e respectivas sanções em caso de descumprimento. Tomando esse processo como um caso emblemático, os autores defendem a rentabilidade teórica do conceito de “política da escala” para a compreensão da natureza dos conflitos suscitados e fazem uma reflexão crítica sobre os dispositivos escalares em sua relação com os novos instrumentos disponíveis para o trato da metropolização brasileira.
O transporte público coletivo sob a lógica da produção capitalista do espaço: uma análise do serviço de ônibus na Região Metropolitana do Recife
Authors: Silva Marília do Nascimento , Lapa Tomás de Albuquerque
Published: June 2019

Resumo Nas sociedades urbanas atuais, o crescimento do papel do Estado convive com o processo de privatização dos serviços prestados por esse aparelho. A justificativa tradicional está na busca por maior competitividade e eficiência nos serviços prestados. Mesmo o Estado sendo cada vez mais indispensável na mediação entre os interesses privados e coletivos, no caso do transporte público coletivo, no contexto brasileiro, a lógica que o constituiu, enquanto serviço de “caráter essencial”, o exime da responsabilidade pública que lhe cabe, abrindo janelas para uma discussão em torno da dinâmica de gestão e de funcionamento desse equipamento. Este artigo analisa o transporte público coletivo, na Região Metropolitana do Recife, sob a lógica da produção capitalista do espaço.
Impasses e oportunidades para a construção de um Sistema Regional de Inovação no Grande ABC
Authors: Anau Roberto Vital
Published: June 2019

Resumo O artigo trata das oportunidades e desafios para a construção de um Sistema de Inovação Regional no Grande ABC Paulista, subconjunto de sete municípios da Região Metropolitana de São Paulo. A partir da caracterização dos traços fundamentais da região, de sua história recente e de seus dados econômicos, resgata-se o esforço da primeira década e meia do século XXI com vistas à citada construção. Com base nos elementos colhidos em pesquisa estatística, documental e de entrevistas, identificam-se os pontos fortes e as lacunas do processo. Conclui-se com elenco de sugestões para a revitalização daquele esforço, sob novas diretrizes e novo arranjo de governança da instituição incumbida do fortalecimento da economia regional – a Agência de Desenvolvimento Econômico do Grande ABC.
Comparison of stress in freshman and senior nursing students
Authors: Mussi Fernanda Carneiro , Pires Cláudia Geovana da Silva , Carneiro Luciana Santos , Costa Ana Lúcia Siqueira , Ribeiro Fernanda Michelle Santos e Silva , Santos Andréia Ferreira dos
Published: June 2019

ABSTRACT Objective: To compare stress levels in freshman and senior nursing students. Method: A cross-sectional study was carried out in a public federal university of the state of Bahia, with students who answered questionnaires about sociodemographic variables, academic life, and a scale for assessing stress in nursing students. Chi-square and Fisher’s exact tests were applied to analyze the relationship between variables. To assess proportional trends between ordinal variables and groups, a chi-square test for linear trend was applied. The significance level was 5%. Results: One hundred and fifty-four students participated in the study. There was a tendency to higher stress levels among students in the last year compared to those in the first year, in four out of six domains: Performance of Practical Activities (p=0.00), Professional Communication (p=0.00), Environment (p=0.00) and Professional Education (p=0.00). Conclusion: High levels of stress were observed in students taking the last year. There is a need for broader research that includes other years of the course, an institutional reflection on stress factors and the adoption of an institutional policy that favors a better confrontation of stress factors.
Frailty syndrome in the elderly in elderly with chronic diseases in Primary Care
Authors: Ribeiro Ingrid Alves , Lima Luciano Ramos de , Volpe Cris Renata Grou , Funghetto Silvana Schwerz , Rehem Tania Cristina Morais Santa Barbara , Stival Marina Morato
Published: June 2019

ABSTRACT Objective: To evaluate the frailty syndrome in the elderly nursing diagnosis in elderly with chronic diseases of a health district of the Federal District. Method: A quantitative, descriptive, cross-sectional study was conducted with elderly patients served at the Basic Health Units, who presented arterial hypertension and/or diabetes mellitus. The following were used: a sociodemographic questionnaire, the Mini-Mental State Examination, anthropometric data, evaluation of sarcopenia (measured by body composition), muscle strength and functional capacity, and the identification of NANDA-I nursing diagnosis. A statistical software was used for data analysis. Results: Participation of 78 elderly people, of which 93.6% of had Impaired memory, 93.6% had Impaired physical mobility, 82.1% had Fatigue, 76.9% had Impaired ambulation, 53.8% had Dressing self-care deficit, 43.6% had Activity Intolerance, 35.9% had Social Isolation, 30.8% had Hopelessness, 29.5% had Feeding self-care deficit, 29.5% had Bathing self-care deficit, 12.8% had Toileting self-care deficit, and 10.3% had Decreased cardiac output. Conclusion: The nursing diagnosis Frailty Syndrome in the Elderly allows a multidimensional view of the elderly. Since one factor can cause health problems in several health fields, nurses must intervene early, plan and implement actions in the short and long term.