bluuebunny/crossref_metadata_2025 huggingface dataset:
Neuropsychiatric adverse reactions of leukotriene receptor antagonist, antihistamine and inhaled corticosteroid: A real-world analysis of the Food and Drug Administration (FDA) Adverse Event Reporting
Authors: Bian Sainan , Li Lisha , Wang Zixi , Cui Le , Xu Ying-Yang , Guan Kai , Zhao Bin , Wang Lianglu , Yin Jia
Published: January 2024

Background There are limited real-world studies about the differences of
leukotriene receptor antagonist (LTRA), antihistamine and inhaled
corticosteroid (ICS) associated neuropsychiatric events. We aimed in
this study to summarize the clinical characteristics of drug associated
neuropsychiatric events and compare the differences between different
drug categories. Methods Disproportionality analysis and Bayesian
analysis were used in data mining to screen the suspected
neuropsychiatric events with LTRA, antihistamine and ICS based on the
Food and Drug Administration (FDA) Adverse Event Reporting System
(FAERS) from January 2004 to September 2020. Results A total of 9475
neuropsychiatric events were identified. Neuropsychiatric events related
to LTRA, antihistamine and ICS were 5201 (54.89%), 3226 (34.05%), and
1048 (11.06%), respectively. LTRA related neuropsychiatric events were
more common in patients aged from 4 to 6 years old (18.66%), while
antihistamine and ICS related neuropsychiatric events were more common
in patients with 18 to 44 years old (29.92%) and older than 65 years
old (30.60%), respectively. Montelukast was considered to have the
tightest relationship to neuropsychiatric events, followed by the first
generation of antihistamine. Most neuropsychiatric symptoms occurred
within the first 10 days after drug initiation. Death rate due to
neuropsychiatric events of antihistamine was significantly higher than
LTRA and ICS (p<0.001). Conclusions LTRA associated
neuropsychiatric events was most frequent in 4 to 6-year old children
and most cases occurred with the first 10 days after drug initiation.
Fatality rate due to antihistamine associated neuropsychiatric events
was higher than LTRA and ICS.
Outcome prediction of chronic myeloid leukaemia (CML) in children
Authors: Leung Wing Yan , Cheuk Daniel Ka Leung , Frankie W.T. , Leung Alex Wing Kwan , Chiu Ka Ho , Ho Karin Kar Huen , Li Chak Ho , Chan Godfrey
Published: January 2024

Purpose We evaluated the existing risk assessment tools for CML in
children. Patients and Methods A total of 55 patients from 1.4 to 18.0
years with newly diagnosed CML between 1996 and 2019 were included.
Forty-nine patients presented in the chronic phase, thirty-six of whom
were treated with upfront tyrosine kinase inhibitor (CP-TKI group); one
presented in the accelerated phase and 4 in the blastic phase.
Treatment, survival, responses, and tolerance were evaluated. Results
The median follow-up time was 8.7 years (range, 2 months to 24.3 years).
All patients in the CP-TKI group received imatinib as their first TKI
treatment. Allogenic stem cell transplantation was performed in one
patient after complete cytogenetic response was achieved with imatinib
and in one patient with imatinib failure. Dasatinib and nilotinib were
prescribed as second-line TKI in 5 patients and 4 patients respectively.
The 10-year overall survival (OS), progression-free survival (PFS) and
event-free survival (EFS) of TKI treated group was 97%, 91.4% and
72.3% respectively. The rates of major molecular response and deep
molecular response of TKIs were 81.2% and 67.5% at 60 months. The
EUTOS long-term survival (ELTS) risk grouping did not predict OS, PFS or
EFS. The IMAFAIL risk groups are correlated with the risk of imatinib
failure. Conclusion TKIs resulted in excellent long-term overall and
progression-free survival in children and adolescents with newly
diagnosed CML in the chronic phase. Further studies are required to
modify the existing prognostic scoring system or develop new ones for
children.
Comprehensive post-mortem evaluation in Intrauterine deaths /still births in improving uptake of autopsy and future pregnancy outcomes
Authors: Thakur Seema , Kadam Khushboo , Paliwal Preeti , Singh Shubhnita , Singh Chanchal , Gupta Rachna , Dagar Savita , Jain Sudhir , Sharma Akshatha , Saxena Renu , Saxena Kamal , Kohli Sudha , Thareja Vandana , Saxena Rajni , Caprihan Renu , Grover Vimal , Bhutani Manorma , Gupta Anita , Kumar Neena , Gupta Vandana , Mittal Mamta , Verma Sunita , Jain Arpana , Chakerverty Jyoti , Kapila Mukta , Mittal Swati , Kapoor Sunita , Khurana Deepa
Published: January 2024

Objective: Post-mortem examination of a baby following spontaneous or
missed miscarriage in the second trimester or intrauterine death to
provide a complete or partial explanation of the pregnancy loss. Method:
A total of 100 cases of intrauterine deaths were consecutively collected
from January 2010-May 2019 for etiological diagnosis according to the
standard protocol and involved external examination, dysmorphological
examination, internal examination and full body antero-posterior and
lateral radiographs. Histopathology of placenta was done. Cases were
also subjected to genetic testing such as FISH/microarray. A clinical
correlation was done by a Obstetrician-geneticist to reach an
etiological diagnosis. Results: Two third of cases were referred after
intrauterine death post 30 weeks of gestation. 24/100 cases were with
fetal anomalies.Genetic causes present in 12% cases. 65.5% cases were
associated with the pathology of the placenta. 30% cases were with cord
lesions. The results were inconclusive in 14% of the cases.
Conclusions: In this study we looked for establishing etiological
diagnosis and tried to see contribution of each test in finding the
cause. This will help the obstetrician in counselling parents for the
utility of post-mortem excamination and thus better able to guide for
future recurrence risk and management.
Multimodality in diversity-disturbance relationships for generalized competition-colonization dynamics
Authors: Liao Jinbao , Barabas Gyorgy , Bearup Daniel
Published: January 2024

Disturbance has long been recognized as a critical driver of species
diversity in community ecology. Recently, it has been found that the
well-known intermediate disturbance hypothesis, which predicts a
unimodal diversity-disturbance relationship (DDR), fails to describe
numerous experimental observations, as empirical DDRs are diverse.
Consequently, the precise form of the DDR remains a topic of debate.
Here we develop a simple yet comprehensive metacommunity framework that
can account for complex competition patterns. Using both numerical
simulations and analytical arguments, we show that strongly multimodal
DDRs arise naturally, and this multimodality is quite robust to changing
parameters or relaxing the assumption of a strict competitive hierarchy.
Having multimodality as a robust property of DDRs in competition models
suggests that much of the noise observed in empirical DDRs should be a
critical signature of the underlying competitive dynamics.
SENSITIVITY AND BIFURCATION ANALYSIS OF FUZZY SEIR-SEI DENGUE DISEASE MODEL
Authors: Bhuju Gauri , Phaijoo G.R. , Gurung Dil
Published: January 2024

Dengue is one of the most serious mosquito-borne infectious diseases in
the world. The number of dengue cases is increasing every year
worldwide. In the present work, we discuss the fuzzy epidemic SEIR-SEI
compartmental model with the intervention of bed nets and fumigation to
describe the transmission dynamics of dengue disease. We consider the
biting rate, transmission rate, and recovery rate of the disease are as
fuzzy numbers. We discuss the dynamical behavior of the disease with
different amounts of virus loads. Sensitivity analysis of the model is
performed to compare the relative importance of the model parameters and
to discuss the importance of fumigation, use of bed nets, and the
quality of bed nets. We study the bifurcation of the equilibrium point
of the system with and without fumigation, with and without bed net
users and with different qualities of bed nets. Numerical simulations
are made to illustrate the mathematical results graphically.
Mapping of Surface Radioactive Heat Production from in situ Gamma Spectrometry and Chemical Data of Exhumed Mantle Peridotites from St. Peter and St. Paul Archipelago (Equatorial Atlantic)
Authors: Campos Thomas , Araujo Jose Humberto , Sichel Susanna , Pastura Valeria , Motoki Kenji , Barao Leonardo , Maia Marcia , Brunelli Daniele , Fonseca Estefano , Neto Joaquim Das Virgens , Vargas Thais , Szatmari Peter
Published: January 2024

The mapping of radioactive heat production (RHP) and the respective
radioactive heat flow (RHF) of Saint Peter and Saint Paul Archipelago
(SPSPA), based on radioactive heat-producing elements (RPE) data from
whole-rock chemical analysis and in situ Gamma radiation spectrometry.
The SPSPA show a radioactive heat production that ranging from 0.08 to
0.68 μW/m3 (Median: 0.21 μW/m3 and Geometric mean: 0.25 μW/m3) by
whole-rock chemical analysis and among 0.08 to 0.48 μW/m3 (Median: 0.19
μW/m3; Geometric mean: 0.19 μW/m3) by in situ Gamma radiation
spectrometry. The mean of radioactive heat production of mylonite rocks
from SPSPA (0.22 μW/m3) is significantly high concerning those predicted
for ultrabasic rocks due to the geological alteration process. The
respective average surface radioactive heat flow (49.7 mW/m2) is to
lower in relation to those predicted for the oceanic lithosphere, which
indicates that the additional heat flow from the upper mantle is also
low in the SPSPA area. Our date and another geological feature suggest
that lithospheric mantle around the SPSPA area is colder than the upper
mantle outside the Equatorial Atlantic area.
Microgel emulsion loaded with recombinant oil body as a new carrier for drug delivery regulates inflammatory response, proliferation and remodeling
Authors: Lan Xin , Li Jing , Wang Rui , Guo Jin , Ma Li , Qiang Wei , Du Lin , Li Xiaokun , Yang Jing
Published: January 2024

Background and Purpose:The skin is an important barrier to protect the
body from external damage, there are tens of millions of patients with
various skin defects. Due to the complex process of wound repair, it is
easy to cause poor healing and other problems. Wound healing procedures
have a systematic multi-stage: hemostasis, inflammation, proliferation
and remodeling. Here, we prepared a new bio- responsive transdermal oil
body microgel emulsion (OBEME) for drug delivery carrier. Experimental
Approach: OBEME was stored at room temperature for 90 days, and its
stability was evaluated by low speed centrifugation and repeated
freeze-thaw treatment. The transdermal penetration of OBEME was proved
by transdermal administration, and the effect of OBEME on wound healing
was investigated in the model of full-thickness skin defect. Key
Results: OBEME was stably stored at room temperature for 90 days and is
not affected by low-speed centrifugation and repeated freeze-thaw. It
was proved to have a good sustained release effect through percutaneous
administration. The OBEME significantly promoted wound healing,
regulated inflammatory response, and accelerated angiogenesis,
re-epithelialization and remodeling. Conclusion and Implications: Taken
together, the OBEME is a good new carrier for percutaneous drug delivery
that can promote wound healing and it has a good sustained-release
effect and can induce the correct repair of skin, which lays a
foundation for the development of new topical drugs.
Infectious endocarditis of the mitral valve with hypertrophic cardiomyopathy in Costello syndrome
Authors: Ishida Shinichi , Mutsuga Masato , Fujita Takashi , Yagami Kei
Published: January 2024

Costello syndrome is a rare congenital disease caused by activating
germline mutations, and it is often associated with cardiac
abnormalities. A 17-year-old male, who had a history of Costello
syndrome, presented with persistent fever. The vegetation attached to
anterior mitral leaflet was detected, and antibiotic therapy was
administered as treatment for infectious endocarditis. However, it was
difficult to manage his heart failure owing to the worsening of mitral
valve regurgitation. Therefore, mitral valve repair with vegetation
resection was performed. His hypertrophic cardiomyopathy and systolic
anterior motion caused left ventricle outflow tract obstruction. A
floating stitch on the anterior mitral leaflet from the posterior ring
annulus was effective. Herein, we report a successfully repaired case of
infectious endocarditis on the mitral valve with hypertrophic
cardiomyopathy complicated by Costello syndrome.
Laccase-catalyzed poly(tyrosine) grafting improves the performance of wool
Authors: Li Yu , Noro Jennifer , Li Jie , Silva Carla , Su Jing , Cavaco-Paulo Artur
Published: January 2024

The laccase-assisted grafting of poly(tyrosine) was performed aiming to
impart shrink-resistant properties to the wool materials. Laccase was
able to efficiently catalyze the oxidation of tyrosine into dityrosine.
When the reaction was performed using poly(ethylene glycol) (PEG) as
template, the tyrosine oxidation gave rise to differentiated oxidation
products, including di-, tri- and tetratyrosine, promoting also a higher
grafting onto the wool fibers. The characterization of the grafted wool
fibers and fabrics revealed some loss of crystallinity (about 4% of
crystallization index) and thermal resistance (decreasing from 232 ºC to
224 ºC) resulting from the grafting process. However, the new bonds
established between the new oxidation products and the amino groups of
the wool, promoted an improvement, not only of the shrinkage properties
(1.87% of area shrinkage), but also of their mechanical behavior
(increasing by 45.28%). The strategy herein presented demonstrated
potentiality to be applied as a “green” process for wool
anti-shrinkage without compromising the fibers’ performance.
Timeline for Carotid Blow-out in Head and Neck Cancer Patients, When to Expect Major Bleeding?
Authors: Yener Murat , Kara Sinem , Aliyeva Chinara , Tevetoglu Firat
Published: January 2024

Abstract: Objectives: Carotid blow-out syndrome (CBS) is one of the
uncommon yet detrimental complications in head and neck cancer patients,
by presenting itself as a catastrophic bleeding. Various factors are
related with CBS. There is no timeline for the development of CBS in
patients with uncontrollable tumors. In this report we intended to
review our cases of CBS with special emphasis on risk factors, the
timeline for carotid rupture as well as the outcomes following ligation.
Design, Setting and Participants: A retrospective analysis was performed
on previously treated head and neck cancer patients who experienced
carotid blow-out syndrome (CBS) following tumor recurrence between 2015
and 2020. Results: All of the patients in this study were classified as
type III CBS and managed by carotid artery ligation. Three patients had
previous chemoradiotherapy while five had surgery and adjuvant treatment
as the primary treatment. Time to recurrence following primary treatment
was ranging between 6-19 months with a mean of 8.25±5.11 months. Apart
from tumor infiltration seen in all of the patients, 3 had fistula, 5
had wound infection and 6 had necrosis. Conclusion: CBS is an uncommon
yet detrimental complication encountered in head and neck cancer
patients, which is mostly treated by endovascular approach. However,
surgical ligation is still a treatment option especially in patients
with type III rupture. Since, there is a limited time for those patients
preventive measures should be undertaken within 4 months following soft
tissue exposure, necrosis and fistula.
Virtual Reality Experience during Labour (VIREL); a qualitative study
Authors: Musters Anne-Claire , Vandevenne Ann-Sofie , Franx Arie , Wassen Martine
Published: January 2024

Objective: There is increasing evidence that virtual reality (VR) is
effective in the reduction of labour pain. The aim of this study is to
examine women’s experiences, preferences and satisfaction in regard to
the use of VR during labour. Design: Qualitative interview study.
Setting: A non-university teaching hospital in The Netherlands.
Population: Women with a singleton pregnancy, scheduled for induction of
labour. Methods: Two VR applications, respectively a guided meditation
(VR1) and an interactive game (VR2) were tested. Labour pain before and
directly after VR was evaluated using the NRS score. Main outcome:
measures Patients’ VR experience and application preference were
examined using a post-intervention questionnaire and a semi-structured
interview. Results: 24 women, of whom fourteen were nulliparous and ten
multiparous, were included and 12 of these women participated in
semi-structured interviews. Three themes were identified after data
analysis: “The VR experience”, “Pain reduction”, and “Usability of
the VR application”. All patients were highly satisfied with VR use
during labour and reported pain reduction during VR. VR1 was preferred
above VR 2 by 17 (71%) women. Both VR1 and VR2 caused a significant
decrease in mean NRS scores comparing pain pre-VR use to pain during VR
use, of respectively 1·81 (VR1) vs. 1·28 (VR2). Conclusion: All women
were highly satisfied with VR use during labour, preferred guided
meditation and experienced less pain. These results can contribute to
the development of a potential promising new non-pharmacological tool to
reduce labour pain. Funding: None.
Angioplasty induces epigenomic remodeling in injured arteries
Authors: Zhang Mengxue , Wang Bowen , Urabe Go , Ozer Gulcin , Han Renzhi , Kent Craig , Guo Lian-Wang
Published: January 2024

Background: Neointimal hyperplasia (IH) is the primary etiology of
stenotic vascular diseases. It is perpetuated principally by smooth
muscle cell (SMC) proliferation -an epigenetic event. Epigenome-scale
studies concerning IH have been confined to in vitro models, and the
epigenetic mechanisms governing SMC/neointima proliferation are not well
understood. Experimental Approach: Using an IH-inducing angioplasty
model in rat carotid arteries, we performed chromatin
immunoprecipitation coupled with high-throughput sequencing (ChIPseq) to
determine epigenomic remodeling. Key Results: Angioplasty induced a
genome-wide surge of histone-3/lysine-27 trimethylation (H3K27me3), a
gene repression mark. This was unexpected, as gene activation rather
than repression is traditionally regarded as dominating neointima
proliferation. ChIPseq further revealed the co-localization of gene
activation mark H3K27ac(acetylation) with its reader BRD4 at the gene of
H3K27me3 writer -enhancer of zeste homolog-2 (EZH2). Accordingly, EZH2
expression was abated by either BRD4-silencing or deletion of
BRD4/H3K27ac-associated enhancer in SMCs. In vivo, while SMC-specific
BRD4 knockout in BRD4fl/fl; Myh11CreERT2 mice reduced H3K27me3 and IH in
wire-injured arteries, EZH2 loss- and gain-of-function respectively
mitigated and exacerbated IH in rat arteries. Furthermore, angioplasty
induced a shift of H3K27me3 ChIPseq-peaks from pro-proliferative genes
(e.g. Uhrf1, Ccnd1) to anti-proliferative genes such as Cdkn1c, in favor
of de-repression of the former and repression of the latter. Conclusion
and Implications: This study unravels angioplasty-induced loci-specific
H3K27me3 redistribution in the epigenomic landscape that entails
BRD4->EZH2 hierarchical regulations. The new knowledge may
lend implications for treating IH, given that EZH2 and BRD4 are both
pharmacological targets in human trials.
Does Individuals with Type 2 Diabetes Mellitus Acceptance of Illness, Emotional Distress and Depression Affect The Nutritional Status and Quality of Life?
Authors: Özyalcın Büşra , SANLIER Nevin
Published: January 2024

Aim The aim of the study was to determine the affect of individuals with
type 2 diabetes mellitus (DM) acceptance of illness, emotional distress,
depression on nutritional status, life quality. Methods This study was
conducted in 145 type 2 DM, 73 males and 72 females, ranging in age from
20-65 years. The Acceptance of Illness Scale (AIS) for the determination
of individuals’ acceptance of the illness, Problem Areas in Diabetes
(PAID) Scale for emotional distress, Beck Depression Scale (BDS) for
depression, Short Form-36 (SF-36) scales for quality of life and Healthy
Eating Index-2010 (HEI-2010) for diet quality was used. Results: The
mean score of individuals’ AIS were 30.2±5.62. Compared to women, men
had lower emotional distress and depression levels (p<0.05),
higher physical, mental life quality (p<0.001). The mean score
of individuals’ HEI-2010 were 54.8±12.85 and more than half of the
individuals had diet quality required to be improved. Models that were
emotional distress and SF-36 Mental Component Summary (MCS) with
acceptance of illness (F(2, 142)=58.404); AIS, BDS and age (years) with
emotional distress (F(3, 141)=53.174); emotional distress and SF-36 MCS
with depression status (F(2, 142)=82.029); acceptance of illness and
depression status with SF-36 MCS (F(2, 142)=70.937); emotional distress
and depression status with SF-36, Physical Component Summary (PCS) (F(2,
142)=42.926) were statistically significant (p=0.000). Also,
correlations among AIS, PAID Scale, BDS, SF-36 were found to be
significant (p<0.05). Conclusions: The presence of diabetes
does not require to have different nutritional habit on individuals
without diabetes. Although the diet quality of individuals with type 2
DM is not primarily related to the individual’s acceptance of the
illness, emotional distress, depression status and quality of life, the
status of medical nutrition as a part of medical treatment by the
individual is one of the important criteria in determining the
priorities in diabetes management.
Effect of Age on Percutaneous Nephrolithotomy for Staghorn Renal Stones
Authors: Sahan Murat , Yarımoğlu Serkan , Savun Metin , Erdemoglu Onur , Degirmenci Tansu
Published: January 2024

Objective: To evaluate the effect of age on the success and
complications of percutaneous nephrolithotomy(PCNL) in staghorn renal
stones. Material and Methods: The files of 182 patients who underwent
single-access PCNL for staghorn renal stones between 2012 and 2017 were
retrospectively analyzed.The patients were divided into two groups
according to their age: those aged <65 years were defined as
Group-1 and those aged ≥65 years as Group-2.The demographic
characteristics and perioperative and postoperative results of the
patients were compared between the two groups.Postoperative detection of
stones>4 mm was defined as residual stones.Complications
were classified according to the Clavien scoring system. Results: Of the
patients with staghorn renal stones,139 were in Group-1 and 43 were in
Group-2. The mean age of the patients was 43.9±10.6 years for Group-1
and 67.8±2.1 years for Group-2(p=0.001).The mean stone size in Group-1
and Group-2 was 899±292 and 1,008±208 mm2, respectively(p=0.736). When
we evaluated the postoperative results, we observed that the amount of
hemoglobin drop was statistically significantly higher in
Group-1(p=0.001). However, the need for blood transfusion was higher in
Group-2 than in Group-1(18.6% and 7.2%, respectively). The stone-free
rate was 54.7% in Group-1 and 67.4% in Group-2(p=0.139). According to
the evaluation of the overall complication rates,34.5% of the patients
in Group-1 and 46.5% of those in Group-2 developed
complications(p=0.206). When we examined the subgroups of complications
according to the Clavien scoring system, the rate of minor complications
was found to be 22.3% in Group-1 and 41.9% in Group-2,and the
difference was statistically significant(p=0.012). The major
complication rates were determined as 4.7% and 12.2% for Group-1 and
Group-2,respectively(p=0.155). The number of patients with Clavien
grade-2 complications was statistically higher in the elderly patient
group(p=0.019). Conclusion: PCNL can be used as an effective and safe
treatment method in the treatment of complex stones in elderly patients
Strategi Pengembangan Agroindustri Keripik Kulit Ikan Patin (Studi Kasus pada Rafin's Snack Kabupaten Pringsewu)
Authors: Nismara Anindya Putri , Haryono Dwi , Affandi Muhammad Irfan
Published: January 2024

This study aims to analyze the development strategy of Pangasius skin chips agroindustry. The location of this research was determined with consideration of Rafin’s Snack is the largest chip agroindustry in Pajaresuk District and yet still has the potential to be developed. Respondents in this study consisted of various parties involved to the analysis of development strategy for the agroindustry, namely agroindustry owners, representatives of the Pringsewu District Fisheries Service, the Office of Cooperatives, SMEs, Industry and Trade of Pringsewu District, and a lecturer at the University of Lampung. Data was collected in January 2023. The analytical method used was SWOT analysis (Strength, Weakness, Opportunity, Threat) and QSPM (Quantitative Strategic Planning Matrix) analysis. The results showed that the main strength of Rafin's Snack Agroindustry is the availability of sufficient raw materials, the main weakness is limited capital, the main opportunity is wide market reach, the main threat is the change in people's tastes. The prioritized development strategies for Rafin's Snack Agroindustry are to do consumer research and to adapt by creating more flavors to the product, to use a cloud-based cashier application (point of sale) in making transactions, to use electronic word of mouth (eWOM) by using the services of influencers or key opinion leaders (KOL) for promoting product and improving brand awareness, to organize educational seminars in collaboration with universities (business goes to campus) to strengthen brand identity and build consumer trust, as well as to utilize production machine provided by the Pringsewu District Fisheries Service.
SIKAP, POLA KONSUMSI, DAN FAKTOR-FAKTOR YANG MEMPENGARUHI KONSUMSI KONSUMEN RESTAURANT CEPAT SAJI (FAST FOOD) DI BANDAR LAMPUNG
Authors: Yuliana Dinda Anisa , Adawiyah Rabiatul , Kasymir Eka
Published: January 2024

Thisl studyl aimsl tol analyzel thel attitude ofllconsumers, foodl consumption pattern, andl factors affecting thel consumption at fast foodl restaurant inl Bandar Lampungl City. Thisl research wasl conducted atlinternational franchised fast food restaurants inl Bandar Lampungl City. Thel research methodl is al survey withl the accidentall sampling ltechnique. Thel number ofl samples inl this researchl were 70 consumers whol had bought or consumed at international franchised fast food restaurants atl least oncel in thel last onel month. Thel research datal were analyzedl by usingl fishbein lmulti-atribute lanalysis, descriptivel statistics analysis, andl multiple linear regressionl analysis. Datal collection wasl conducted from lJune-Julyl 2022. Thel results showedl that thel consumers who boughtl or consumed atlinternational franchised fast food restaurants is because of its taste, hygiene, and services. Consumers more likely to buy at a international franchised fast food restaurants that served fried chicken as it main course like McD and KFC. The average amount of purchased were two menus per transaction and average amount of frequency were three times per month with reason of purchased were great taste, easy to find, and practical. Factors that affected the consumption were incomes, international franchised fast food restaurant’s prices, and consumers habitual variables.
ANALISIS PENGARUH HARGA, LOKASI DAN KUALITAS PRODUK TERHADAP KEPUTUSAN PEMBELIAN BUAH DAN SAYUR DI SUPERMARKET HOKKY PANGLIMA SUDIRMAN SURABAYA
Authors: Prastiwi Feby Anggita , Yuliati Nuriah , Laily Dona Wahyuning
Published: January 2024

The level of consumption of fruit and vegetables per capita in a year in East Java has increased, but the level of consumption of fruit is still lower than vegetables. The emergence of fruit marketing companies, both supermarkets and shops, resulted in intense competition to overcome the increasing competition in seizing market opportunities. This study analyzes consumer characteristics and analyzes the effect of price, location, and product quality on fruit and vegetable purchasing decisions at Hokky Panglima Sudirman Supermarket Surabaya. This research was conducted at the Hokky Panglima Sudirman Supermarket, Surabaya. The sampling technique was accidental sampling with 80 respondents. The sample criteria used are consumers who buy fruit and vegetables at the Hokky Panglima Sudirman Supermarket, Surabaya. The analysis method uses SEM-PLS with the help of WarpPLS version 8.0 software. The results of this study indicate that price, location, and product quality have a positive and significant effect on fruit and vegetable purchasing decisions at Hokky Panglima Sudirman Supermarket SurabayaKey words: place, price, product quality, purchasing decisions, supermarket
ANALISIS KINERJA ATRIBUT DI RUMAH MAKAN AYAM BAKAR MBOK JUM WAY HALIM KOTA BANDAR LAMPUNG
Authors: Hutajulu Yohana Fransiska Elizabet , Hudoyo Agus , Saleh Yuliana
Published: January 2024

This study was conducted to identify the attributes that consumers value most at Mbok.Jum Way Halim Restaurant, Bandar Lampung City. There are various attributes that can be held in a restaurant. Each attribute that is held certainly costs money, if all the attributes are considered, then the restaurant will spend a lot of money. The restaurant must know what attributes are prioritized that are adjusted to what is considered important by consumers. Therefore, this research was done to determine what attributes buyers deem crucial and what attributes need to be preserved to enhance performance. This study employed a survey methodology and involved questionnaire interviews with 60 participants. Importance Performance Analysis (IPA) has been employed as the analytical technique. The study's findings demonstrated that, of the 20 attributes considered, 13 attributes are regarded as being crucial and 7 attributes that perform satisfactory. Attributes that must be preserved in their performance are the taste of the food, the size per serving, the friendliness and courtesy of the waiters, the accuracy of the presentation, the cleanliness of the tableware, the availability of parking space and the available alternatives for seating. The performance attributes that require improvement include price, the readiness of waiters to respond to consumers’ complaints, service speed, facility cleanliness, availability of water in the sink, and cleanliness of the toilet.  Key words: Attributes, important performance analysis (IPA), performance, restaurant
Praktické prípady z práva obchodných spoločností
Authors: Kubinec Martin , Ušiaková Lenka , Dzimko Jakub
Published: January 2024

Vysokoškolská učebnica s názvom „Praktické prípady z práva obchodných spoločností“ sa zaoberá vybranými otázkami zameranými na problematiku práva obchodných spoločností. Inovatívna zbierku prípadových štúdií sleduje osud a najčastejšie životné situácie najfrekventovanejšej právnej formy – spoločnosti s ručením obmedzeným, a to na modelovom prípade imaginárnej spoločnosti. Zbierka prípadových štúdií umožňuje študentom precvičiť si už získané teoretické vedomosti o založení a vzniku spoločnosti, postavení jej orgánov, prevodoch obchodných podielov, zániku účasti spoločníka, neplatnosti uznesenia valného zhromaždenia, zrušenia, likvidácie a zániku, či premeny spoločnosti; a to spravidla aj s nevyhnutnými presahmi do iných právnych foriem.
The Understanding by Design Strategy in 21st-Century Education
Authors: Dari Wulan , Hidayat Saleh , Wulandari Eka
Published: January 2024

The 21st-century learning One, solution that can be used is by using the Understanding by Design (UbD) curriculum. The aim of this research is to examine the application of UbD in teaching, the implementation of UbD in Indonesia, expected student learning outcomes within the UbD framework, and the role of teachers in the implementation of UbD. The method used is the literature study method. The data analysis technique uses deductive qualitative analysis. The results obtained are that UbD learning can be used as a reference in preparing learning implementation plans that are oriented towards learning goals. Learning using UbD has not been fully implemented by all teachers in Indonesia, because there are still many teachers who prioritize the results of final grades rather than students' understanding. The implementation of UbD has actually been planned in the latest curriculum, namely the independent curriculum, but this curriculum has not been fully implemented by all schools. In implementing UbD, students are expected to have 6 abilities, namely explaining, interpreting, applying, taking a perspective, empathizing and having self-knowledge. The role of teachers is very essential in UbD, which involves designing, implementing, and directing learning activities.ABSTRAK. Pembelajaran abad 21, salah satu solusi yang dapat digunakan yaitu dengan menggunakan kurikulum Understanding by design (UbD). Tujuan penelitian ini yaitu untuk mengkaji penerapan UbD dalam pembelajaran, implementasi UbD di Indonesia, hasil pembelajaran peserta didik yang diharapkan dalam kerangka UbD dan peran guru dalam implementasi UbD. Metode yang digunakan yaitu dengan metode studi kepustakaan. Teknik analisis data menggunakan analisa kualitatif deduktif. Hasil yang didapatkan yaitu strategi UbD dapat dijadikan sebagai acuan dalam menyusun perencanaan pelaksanaan pembelajaran yang berorientasi kepada tujuan pembelajaran. Pembelajaran menggunakan UbD belum sepenuhnya diterapkan oleh semua guru di Indonesia, karena masih banyak guru yang mementingkan hasil nilai akhir dibandingkan pemahaman peserta didik. Penerapan strategi UbD sebenarnya sudah dicanangkan di kurikulum terbaru yaitu kurikulum merdeka, tetapi kurikulum ini belum sepenuhnya diterapkan oleh semua sekolah. Pada penerapan strategi UbD, peserta didik diharapkan memiliki 6 kemampuan yakni menjelaskan, interpretasi, menerapkan, melakukan perspektif, berempati dan memiliki pengetahuan diri. Peran guru sangat esensial dalam UbD, yaitu merancang, melaksanakan dan mengarahkan kegiatan pembelajaran.
How discovery learning effect student’s critical thinking in biology based local potential?
Authors: Imtihana Ezif Rizqi , Utami Riani Ken
Published: January 2024

This study aims to determine how the effect application of discovery learning on students' critical thinking and how the influence of discovery learning on each indicator of critical thinking. This research is quasi-experiment with pretest-posttest control group design. This research was conducted at 3 SMA Pacitan District, there are SMANA Punung, SMAN B Pacitan, and SMAN C Ngadirojo. The population used in this study were all students of class X Science in 3 schools as research object. Data collection techniques in this study were carried out using test techniques. Data analysis technique in this study was carried out through Wilcoxon test while to find out how much students' critical thinking skills increased, N-gain calculations were carried out. The results showed that there were significant differences in influence of local potential-based discovery learning models on critical thinking aspects of interpretation indicators, analyzing and concluding students with Asymp scores. Sig. (2-tailed) < α value (0.000 < 0.05).ABSTRAK: Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh penerapan discovery learning terhadap bepikir kritis siswa serta bagaimana pengaruh discovery learning pada tiap indikator berpikir kritis. Penelitin ini merupakan quasi-experimen dengan desain penelitian pretest-posttest control group design. Penelitian ini dilaksanakan di 3 SMAN Kabupaten Pacitan yaitu SMAN A Punung, SMAN B Pacitan, dan SMAN C Ngadirojo. Populasi yang digunakan dalam penelitian ini yaitu seluruh peserta didik kelas X IPA di 3 sekolah yang menjadi objek penelitian. Teknik pengumpulan data dalam penelitian ini yaitu dilakukan menggunakan teknik tes. Teknik analisis data dalam penelitian ini dilakukan melalui uji Wilcoxon sedangkan untuk mengetahui seberapa besar peningkatan keterampilan berpikir kritis peserta didik dilakukan perhitungan N-gain. Hasil penelitian menunjukkan bahwa terdapat perbedaan pengaruh yang signifikan antara model discovery learning berbasis potensi lokal terhadap aspek critical thinking pada indikator interpretasi, menganalisis dan menyimpulkan peserta didik dengan perolehan nilai Asymp. Sig. (2-tailed) < nilai α (0,000 < 0,05).
Application of the Environmental Exploration Approach (JAS) Assisted by QR Codes to Increase Scientific Literacy Aspects of Competency and Conservation Attitudes in Plantae Material
Authors: Darwati Een , Ubaidillah Mujib , Sahrir Dede Cahyati , Oktina Sari Annisa Oktina Sari
Published: January 2024

The purpose of this study was to describe student learning activities, to analyze the differences in increasing scientific literacy in the aspect of student competency and to analyze the increase in conservation attitudes of class X students in plantae material which was taught using the Natural Surroundings (JAS) approach assisted by the QR Code. This research is a quantitative study with a sample of 31 students of class X MIPA 1 control class and 32 students of class X MIPA 3 experimental class. The research design used was the pretest posttest control group model. Data collection techniques in this study used observation, tests and questionnaires. The results showed that there was an increase in student learning activities at each meeting. There is a significant difference in increasing scientific literacy in the competency aspect in indicator 2 with a significance value of 0.000. And there is an increase in conservation attitudes after the learning treatment. Based on the results of the study it can be concluded that the application of learning using the Natural Surrounding Exploration (JAS) approach assisted by the QR Code can increase student learning activities, scientific literacy aspects of competence and students' conservation attitudes towards biology learning.ABSTRAK: Tujuan dalam penelitian ini yaitu untuk mendeskripsikan aktivitas belajar siswa, untuk menganalisis perbedaan peningkatan literasi sains aspek kompetensi siswa dan untuk menganalisis peningkatan sikap konservasi siswa kelas X pada materi plantae yang diajarkan dengan pendekatan Jelajah Alam Sekitar (JAS) berbantuan QR Code. Penelitian ini merupakan penelitian kuantitatif dengan sampel sebanyak 31 siswa kelas X MIPA 1 kelas kontrol dan 32 siswa kelas X MIPA 3 kelas eksperimen. Desain penelitian yang digunakan yaitu model pretest posttest control group. Teknik pengumpulan data dalam penelitian ini menggunakan observasi, tes dan angket. Hasil penelitian menunjukkan bahwa terdapat peningkatan aktivitas belajar siswa pada setiap pertemuan. Terdapat perbedaan peningkatan literasi sains aspek kompetensi yang signifikan pada indikator 2 dengan nilai signifikansi 0,000. Dan terdapat peningkatan sikap konservasi setelah perlakuan pembelajaran. Berdasarkan hasil penelitian dapat disimpulkan bahwa penerapan pembelajaran dengan menggunakan pendekatan Jelajah Alam Sekitar (JAS) berbantuan QR Code dapat meningkatkan aktivitas belajar siswa, literasi sains aspek kompetensi dan sikap konservasi siswa terhadap pembelajaran biologi.
The Effect of Exchange Rate of The Rupiah, Money Supply, Inflation, and BI Rate on Sharia Bank Financing During the Covid-19 Pandemic
Authors: Laila Qiftiyah  , Santi Yustini
Published: January 2024

The Covid-19 pandemic is an event of the spread of the 2019 Coronavirus disease. The pandemic has had a significant impact on the development of the world economy, especially the Islamic Banking Industry. The research used is quantitative research with an associative approach using multiple linear regression. The population used by Islamic banks and the samples used in this study are saturated and non-probability samples. This study aims to analyze the factors that influence the financing of Islamic commercial banks. Based on the results of the regression test, it proves that the rupiah exchange rate and inflation have no effect on sharia commercial bank financing, while the BI rate and money supply have an effect on sharia commercial bank financing.
Analysis of Bank Health Level Using the RGEC Method at BCA Syariah
Authors: Muhammad Iqbal Surya Pratikto  , Jihan Farera  , Lilik Rahmawati  , Imam Ali Mustofa
Published: January 2024

In carrying out its duties as an intermediary institution, banks must be careful and pay attention to the risk aspects that can result from operational activities of fund management, because banks manage deposits of funds from the public. Therefore, banks are obliged to maintain and maintain the mandate of the community by managing funds carefully and paying attention to risk management which can affect the level of bank health. The purpose of this study is to determine the health level of BCA Syariah Bank from 2017 to 2021 based on the RGEC method which includes four components, namely Risk Profile (Risk Profile), GCG (Good Corporate Governance), Earning (Rentability), and Capital (Capital). This research method uses quantitative research methods with a descriptive approach. The type of data used in this study is secondary data obtained from the financial statements of BCA Syariah Bank for five consecutive years from 2017 to 2021. The results of this study indicate that the health level of Bank BCA Syariah from 2017 to 2021 as measured using the RGEC method through eight indicators (NPF, FDR, PDN, ROA, ROE, NI, BOPO, and CAR) received a Very Healthy predicate.
Reinterpreting Modern Monetary Theory Through an Islamic Lens: Insights from Indonesia's Economic Thought
Authors: Dini Anggreini Khairunnisa  , Nofrianto
Published: January 2024

Modern Monetary Theory (MMT) has gained attention, particularly following the crisis caused by COVID-19, which led every country to experience a significant decline in economic growth. This concept proposes the idea that a central bank can create money to finance real sector activities without having to borrow from specific parties, which is then believed to solve various economic problems. This theory has sparked various disagreements within conventional economics. Therefore, in countries that adopt dual economic systems, they certainly have their own perspectives when considering this monetary theory. This research utilizes library documentation or collected reading sources as data sources. The research findings suggest that the concept of MMT is not in conflict with Islamic Sharia, as the MMT concept aligns with the functions of money described by Al Ghazali and Ibn Khaldun. Hence, the MMT concept is not expected to lead to excessive inflation, as it conforms to the Islamic theory of the function of money, where money serves as a medium of exchange rather than a tradable commodity. With this concept, the quantity of goods in a country will be accompanied by the Money Supply. However, the application of economic theories like MMT must be adapted to the conditions and economic concepts of a given country. Despite MMT's compatibility with Islamic monetary concepts, Indonesia is not yet ready to fully implement MMT, which is why the predicted level of moral hazard risk is higher.
Implementation of Inner Syariah Digital Marketing Strategy Increasing Iwa-Qu Shop Turnover
Authors: Sri Rahma  , Rohana  , Fauzan Ramli  , Cut Laena  , M. Irfan Assid
Published: January 2024

This research is motivated by advances in internet technology which are currently growing rapidly in society. Digital marketing strategies are an alternative way for business people to reach consumers very broadly and quickly in promoting their products via the internet and to increase sales volume. The purpose of this research is to know the syariah digital marketing strategy in increasing the turnover of the Iwa-Qu store. This study uses a descriptive qualitative approach with data collection methods through interviews, observation and documentation. Based on the results of the research and discussion, it can be concluded that implementing a syariah digital marketing strategy in increasing the turnover of Iwa-Qu stores, namely through whatsapp Business, Instagram, shoppe food and go food.
Strategies for Strengthening the Competitive Advantage of Export Halal Food Products in Optimizing Expansion in the Global Market
Authors: Fitri Desvaria  , Rindiani Fenissa Aulia  , Maratuz Solihah  , Abisar Pardi  , Kustin Hartini
Published: January 2024

The global market has become an attractive target for manufacturers of imported halal food products to expand their reach and increase their market share. However, the challenges faced in entering and competing in a competitive global market cannot be ignored. This study was conducted to analyze and develop strategies that can strengthen the competitive advantage of exported halal food products in optimizing expansion in the global market. Through a literature review, factors affecting consumer demand and preferences for halal food products, as well as factors affecting the competitiveness of halal food products in the global market were investigated. Based on this analysis, strategies to strengthen competitive advantage are developed, including product quality improvement, innovation development, reliable halal certification, and effective marketing. By adopting these strategies, export halal food producers can gain a strong position in the global market and increase their market share.
Analysis of the Green Banking Implementation Model on Banking Performance at Bank Syariah Indonesia KCP Banjarnegara
Authors: Aprilia Farahita  , Enjen Zaenal Mutaqin  , Dewi Laela Hilyatin  , Muhammad Sirajuddin Qahtan Hamdan
Published: January 2024

The continuous increase in climate change has attracted global attention. Many countries in the world have made the necessary commitments to mitigate climate change. Then this attracts the attention of economic actors, especially for the banking sector, which is known as green banking. The concept of green banking is banking that emphasises the application of sustainability in financial distribution or operational activities. In this case it is the same as that the bank seeks to create environmentally friendly practices by reducing the carbon footprint of banking operations. This study aims to implement green banking practices at Bank Syariah Indonesia KCP Banjarnegara and its impact on banking performance.

This study uses a descriptive qualitative approach with a field research method through direct observation and interviews with the Branch Manager, Operational Staff, Teller and Micro Staff of Bank Syariah Indonesia KCP Banjarnegara. Indicators of green banking activities used in this study include Green Product, Green Operation, Green Customer and Green Policy. 

The results of this study indicate that Bank Syariah Indonesia KCP Banjarnegara implements green banking practices based on research indicators, such as Green Product, Green Operation, Green Customer and Green Policy, of the four indicators Bank Syariah Indonesia KCP Banjarnegara has implemented all indicators well. This has a positive impact on the image and reputation of Bank Syariah Indonesia KCP Banjarnegara as a bank that cares about the environment and social responsibility. In addition, the existence of Operational Efficiency in banking has helped Bank Syariah Indonesia KCP Banjarnegara increase efficiency and reduce costs. The use of technology also speeds up the transaction process and services for customers and increases customer satisfaction.