bluuebunny/crossref_metadata_2025 huggingface dataset:
NeutroMAS4SCRM : a combined multi-agent system with neutrosophic data analytic hierarchy process framework for supply chain risk management
Authors: Meziani Ahlem , Bourouis Abdelhabib , Chebout Mohamed Sedik
Published: November 2022

Effective risk management reaction improves the absorption of critical impacts on supply chains. Supply chain risk (SCR) sources, like control, process, demand, and supply, need to be identified, assessed, and mitigated to make rational decisions immediately. Late detection of a disruptive event can cause delays in handling risk. Since SCRs consist of complex, uncertain, and incomplete information, most of the provided risk assessment mechanisms cannot handle it in real-time. Hence, in this paper, we introduce NeutroMAS4SCRM, a framework incorporating real-time Multi-Agent Systems (MAS) with Neutrosophic Data Analytic Hierarchy Processes to best deal with the complexity, uncertainty, and vagueness of SCR management-related issues and which can hence help decision-makers adopt less risky decisions. In addition, the MAS technology contribution to SCR management is outlined through a comparative study among the most recent studies. In contrast, the proposed MAS for the supply chain is implemented under the JADE agent platform, where the FIPA-ACL-based message content is specified using a dedicated ontology. A simulation-based decision support system is used to assess the cost risk and its harmful effects and determine how well the proposed framework can help companies manage risks efficiently. The simulation has proven to reduce risk costs by about 85%.
Electrical Impedance Myography Correlates with Functional Measures of Disease Progression in D2-mdx Mice and Boys with Duchenne Muscular Dystrophy
Authors: Chrzanowski Stephen M. , Nagy Janice A. , Pandeya Sarbesh , Rutkove Seward B.
Published: November 2022

Background:

Sensitive, objective, and longitudinal outcome measures applicable to both pre-clinical and clinical interventions are needed to assess muscle health in Duchenne muscular dystrophy (DMD). Electrical impedance myography (EIM) has the potential to non-invasively measure disease progression in mice and boys with DMD.

Objective:

We sought to evaluate how electrical impedance values (i.e., phase, reactance, and resistance) correlate to established measures of disease in both D2-mdx and wild type (WT) mice and boys with and without DMD.

Methods:

Histological, functional, and EIM data collected from previous studies of WT and D2-mdx mice at 6, 13, 21 and 43 weeks of age were reanalyzed. In parallel, previously collected functional outcome measures and EIM values were reanalyzed from boys with and without DMD at four different age groups from 2 to 14 years old.

Results:

In mice, disease progression as detected by histological, functional, and EIM measures, was appreciable over this time period and grip strength best correlated to longitudinal phase and reactance impedance values. In boys, disease progression quantified through commonly utilized functional outcome measures was significant and longitudinal phase demonstrated the strongest correlation with functional outcome measures.

Conclusion:

Similar changes in EIM values, specifically in longitudinal reactance and phase, were found to show significant correlations to functional measures in both mice and boys. Thus, EIM demonstrates applicability in both pre-clinical and clinical settings and can be used as a safe, non-invasive, and longitudinal proxy biomarker to assess muscle health in DMD.
Comparison of shoulder functions between assembly workers with and without subacromial pain syndrome
Authors: Kim Jun-Hee , Yi Chung-Hwi , Jeon Hye-Seon , Choi Woochol Joseph , Weon Jong-Hyuck , Kwon Oh-Yun
Published: November 2022

BACKGROUND: The occurrence of subacromial pain syndrome (SPS) is associated with the frequent handling and lifting of heavy loads and excessive repetitive work. Thus, assembly workers have a high prevalence of SPS. OBJECTIVE: The purpose of this study was to investigate differences in shoulder ROM, muscle strength, asymmetry ratio, function, productivity, and depression between workers with and without SPS. METHODS: Sixty-seven male workers (35 workers with SPS and 32 workers without SPS) participated in this study. Shoulder internal rotation (SIR), shoulder external rotation (SER), shoulder abduction (SAB), shoulder horizontal adduction ROM and SIR, SER, elbow flexion (EF), scapular depression and adduction, scapular protraction strength were measured. The asymmetry ratio was calculated using the asymmetry ratio formula; shoulder functions were measured using the shoulder pain and disability index (SPADI), disabilities of the arm, shoulder, and hand (DASH), and visual analogue scale (VAS); and Endicott work productivity scale (EWPS). RESULTS: The SPADI (p = 0.001), DASH (p = 0.001), and VAS (p = 0.001) values of workers with SPS were higher than those of workers without SPS. Also, workers with SPS had lower SIR (p = 0.001) and SAB (p = 0.002) ROM compared to workers without SPS. In addition, workers with SPS exhibited lower SIR (p = 0.012) strength than workers without SPS. Workers with SPS had higher asymmetry ratio in SIR (p = 0.015), SER (p = 0.005), and EF (p = 0.008) strength than workers without SPS. CONCLUSIONS: The SIR, SAB ROM, SIR strength, and the asymmetry ratio of SIR, SER, EF strengths could provide an important baseline comparison for the workers with SPS.
What is it like to be Out-of-Body? Phenomenal accounts of experiencers
Authors: Tressoldi Patrizio , Pederzoli Luciano
Published: November 2022

By using the descriptions of the Out-of-Body experiences of 13 participants, we aimed to have a picture of what it is like to be in this particular state of consciousness. 

All information was grouped according to the following topics: consciousness status, self-boundaries, object perception, color perception, other types of perceptions, interactions with other people or beings, emotions, and time and movement perception.

From the 13 first-person accounts, it emerges a very different way to perceive and know with respect to the perception constrained by the brain and sensory organs. 

Overall, the participants reported positive feelings, a consciousness status characterized by a high level of self-awareness without self-boundaries, and the ability to perceive information with almost all modalities, living in a timeless dimension.
PELATIHAN PEMBELAJARAN STEM DI SEKOLAH DASAR UNTUK MENGEMBANGKAN KETERAMPILAN ABAD 21
Authors: Handayanto Supriyono Koes , Oktarianto M Luthfi , Yasa Arnelia Dwi , Setiyawati Enik , Isbandrianingtyas Nafi
Published: November 2022

Permasalahan dalam pembelajaran STEM saat ini yaitu pembelajaran berbasis STEM belum dilakukan secara optimal. Sebagian besar guru banyak yang mengalami kendala terkait pemanfaatan media berbasis IT. Selain itu, bentuk evaluasi pembelajaran berbasis HOTS belum sepenuhnya dikuasi guru. Pelatihan ini bertujuan untuk meningkatkan keterampilan guru dalam pembelajaran STEM di tingkat sekolah dasar. Metode pelaksanaan kegiatan dilakukan adalah workshop, pendampingan, dan evaluasi. Peserta sasaran terdiri dari guru sekolah dasar gugus satu Kota Malang sebanyak 16 guru. Hasil dari pelatihan ini menunjukkan peningkatan dalam keterampilan guru dengan pembelajaran STEM dengan indikator sebanyak 16 guru telah membuat media pembelajaran berbasis STEM sesuai dengan materi di sekolah dasar. Namun semua hasil produk guru yang dihasilkan diperlukan adanya perbaikan minor. Respon peserta pelatihan juga menunjukkan respon positif dalam pelatihan pembelajaran STEM di sekolah dasar untuk mengembangkan keterampilan pada abad 21.
Pelatihan Optimalisasi Penggunaan Sosial Media Sebagai Sarana Penyampaian Informasi Kepada Warga Desa
Authors: Permatasari Ita , Rahayu Titik , Azis Muhyidin , Sutantohadi Alief , Maaliah Eda , Faizin Halim
Published: November 2022

Informasi merupakan bagian dalam terlaksananya kegiatan bersosial yang erat kaitannya dengan komunikasi. Penyampaian informasi yang efektif dan efisien melalui media tertentu akan menunjang terjadinya komunikasi yang baik. Hal ini berkaitan pula dengan penyampaian informasi yang berasal dari pemerintah desa kepada warga desa. Penggunaan media yang tepat dapat menunjang terjadinya komunikasi dua arah yang baik. Berkaitan dengan hal ini, tim PKM akan melaksanakan kegiatan yang yaitu pelatihan optimalisasi penggunaan media sosial dengan tujuan menyampaikan informasi kepada masyarakat. Kegiatan ini akan dilaksanakan di Desa Tanjungsari, Kecamatan Panekan, Kabupaten Magetan. Peserta kegiatan ini adalah perangkat desa Tanjungsari.Tujuan utama pkm ini adalah memberikan informasi mengenai media sosial yang bisa digunakan untuk menyampaikan informasi kepada warga desa. Selain itu, kegiatan ini bertujuan agara pemerintah desa mampu mengelola media sosial yang bisa digunakan untuk menyampaikan informasi kepada warga secara efektif dan efisian.
Workshop Peningkatan UMKM Melalui Pengelolaan Keuangan Dan Pemasaran di Desa Balongsari
Authors: Sudrajat Ajat , Megawati Liya , Munasto Daud
Published: November 2022

Pengembangan UMKM perlu terobosan dalam meningkatkan usaha melalui pembahasan pengelolaan keuangan dan pemasaran yang harus dilakukan para pelaku UMKM melalui pelaksanaan workshop dengan tujuan untuk memberikan pemahaman dan pelatihan kepada para pemilik UMKM dalam hal pengelolaan keuangan dan pemasaran. Kegiatan ini dilaksanakan pada hari Kamis Tanggal 28 Oktober 2021 melalui kegiatan yang dilakukan secara tatap muka dengan peserta para UMKM yang ada di Desa Balongsari Kecamatan Rawamerta kabupaten Karawang. Peserta dari kegiatan ini berjumlah 50 orang dari jumlah keseluruhan para pelaku UMKM sebanyak 190 orang. Hasil dari kegiatan ini adalah meningkatnya pemahaman Para pelaku UMKM tentang konsep pengelolaan keuangan dan pemasaran dalam pengembangan UMKM.
Motivasi Dan Keterampilan Kewirausahaan Dalam Membentuk Wirausaha Muda Pada Koperasi Pemuda Karawang
Authors: Suyaman Dede , Huda Syamsul , Sutarjo
Published: November 2022

Kegiatan pengabdian kepada masyarakat yang dilakukan dosen beserta mahasiswa sebagai upaya menerapkan Ilmu Pengetahuan yang diperoleh, hasil-hasil penelitian dibidang IPTEK untuk meningkatkan kesejahteraan hidup masyarakat. Melalui pemberian donasi pemberdayaan, pelatihan, penyuluhan, pembimbingan, pendampingan, & buat menyadarkan potensi yangg dimiliki dan membantu menaikkan kualitas hayati & pembangunan baik individu juga desa. Pengabdian masyarakat dilaksanakan dengan tiga tahap yaitu observasi, pelaksanaan program kerja, dan penyusunan laporan. Observasi kami lakukan dengan metode wawancara dan dokumentasi secara langsung sedangkan program kerja kami laksanakan semi online mengingat masih dalam situasi pandemi Covid-19. Tujuan diadakannya program pengabdian masyarakat ini untuk membantu masyarakat pelaku UMKM dalam menyelesaikan masalahnya terkait dibidang pemasaran, pencatatan dan legalitas dan memotivasi kembali para pelaku UMKM atau pun masyarakat yang sedang merintis untuk mengembangkan usahanya. Secara keseluruhan 3 program kerja yang kami rancangkan berjalan dan dapat terlaksana dengan baik, kegiatan kelompok dan kegitaan gabungan berjalan dengan baik dengan dukungan dan doa serta kerjasama dari peserta. Setelah Pengabdian masyarakat ini berakhir di harapkan ilmu ini dapat berguna bagi masyarakat luas dan senantiasa mengembangkan produk UMKM nya agar lebih sukses.
Peningkatan Manajemen Produksi dan Penjualan Produk Banyu Lemon (Sari Lemon) Dengan Memanfaatkan Website Dan Marketplace Di Masa Pandemi Covid-19
Authors: Susena Edy , Sukendar Markus , Setiyanto Riyan , Primadani Afrilia , Maris Yogi , Pangastuti Dewi
Published: November 2022

Pandemi covid-19 yang melanda dunia pada dua tahun terakhir ini telah menyebabkan terpuruknya berbagai sektor, salah satunya sektor ekonomi. Banyak perusahaan besar sampai industri rumah tangga tidak dapat beroperasi. Di masa new normal ini pelan – pelan sektor ekonomi mulai bangkit. Kebangkitan sektor ekonomi tentunya perlu dukungan dari berbagai pihak.

Tim Penerapan Ipteks Masyarakat Politeknik Indonusa Surakarta bekerja sama dengan Direktorat Jenderal Pendidikan Vokasi memberikan dukungan kepada industri rumahan Banyu Lemon Ngargoyoso Karanganyar untuk bangkit lagi. Program yang diberikan adalah Penerapan Ipteks Masyarakat (PIM)

Program Penerapan Ipteks Masyarakat (PIM) yang dilaksanakan di Industri Rumahan Banyu Lemon Ngargoyoso Karanganyar selama 6 bulan mulai bulan Juli-Desember 2022. Kegiatan yang dilakukan adalah Forum Group Disscusion dengan mitra, memproses Izin PIRT ke Dinas Kesehatan Kabupaten Karanganyar, merancang sistem informasi penjualan secara online, mendaftarkan produk Banyu Lemon ke marketplace, membuat varian produk Lemon Madu, mendesain label dan kemasan produk, meningkatkan produktifitas, meningkatkan jumlah agen pemasaran.

Kata kunci: Banyu, Lemon, Sari, online
Edukasi Digital Marketing Dalam Upaya Meningkatkan Pendapatan UMKM Desa Lembak Kabupaten Muara Enim
Authors: Simanjuntak Jainal , Marlina Ressy , Shanshabilla Afreicylia , Oktariani Elza , Putri Muthi’ah , Josse Fernando , Anggraini Leriza , Ratu Mutiara , Purnamasari Endah
Published: November 2022

Usaha Mikro Kecil Menengah (UMKM) Kerupuk dan Kemplang di Desa Lembak adalah salah satu sumber mata pencarian yang di sediakan dan didukung di Desa Lembak sebagai tambahan penghasilan yang didukung oleh pemerintah. Metode pelaksanaan sosialisasi pemasaran kegiatan Bertujuan untuk mendampingi para pelaku UMKM secara langsung Untuk dapat mengetahui cara pemasaran online, karena Media online menjadi peran penting untuk menambah pendapatan untuk para pelaku UMKM Usaha Kerupuk dan Kemplang. Pendampingan dan pelatihan secara langsung kepada pelaku UMKM Kerupuk dan Kemplang agar mereka dapat mengerti apa fungsi dan kegunaan suatu merek dan kemasan yang kami ajarkan. Dengan pengubahan kemasan memang akan mempengaruhi harga dan volume produk, namun keuntungan yang didapat tentu jauh lebih bermanfaat, seperti ketahanan produk jauh lebih tahan lama, dan dengan adanya merek menjadi pembeda antara kerupuk dan kemplang yang lain dipasaran pada umumnya. Perlu untuk kedepannya supaya Pemerintah Memberi Edukasi bahkan tindakan contoh seperti peraturan untuk setiap Pelaku UMKM Kerupuk dan Kemplang di Desa Lembak menggunakan jenis Plastik yang baik, penggunaan merek, dan hal lain yang sifatnya baik untuk kemajuan UMKM Usaha Kerupuk dan Kemplang.
Terapan Iptek Kewirausahaan Untuk Hasil Produk Pengelasan Kepada Masyarakat Kayang Makmur, Kabupaten Madiun
Authors: Mohammad Erik Echsony  , Muhammad Taali  , Alfi Tranggono Agus Salim  , Ina Syarifah  , Rahayu Mekar Bisono  , Khandia Nabil Khoyyiroh  , Rafli Maulana  , Imerlipta Sekar Artianingrum  , Rachel Yogi Iswari
Published: November 2022

Tingkat kemampuan berwirausaha dibidang pengelasan yang dimiliki masyarakat Dusun Kayang Makmur, Desa Bader, Kecamatan Dolopo, Kabupaten Madiun dinilai rendah  karena keterbatasan materi, hal ini berdampak pada perawatan dan perbaikan dalam bentuk pengelasan untuk alat pertanian dari baja yang sebagian besar digunakan oleh masyarakat Dusun Kayang Makmur. Oleh karena itu, diadakannya pelatihan pengelasan dan kewirausahaan yang kemudian hari dikembangkan menjadi suatu ide usaha. Dengan penguasaan keterampilan pengelasan maka produk yang dihasilkan masyarakat desa mampu dijadikan kegiatan berwirausaha dan bersaing pada pasar di era globalisasi. Penyelenggaraan kegiatan program kemitraan masyarakat ini dilaksanakan dengan beberapa parameter yang dapat dicapai luaran dari kegiatan ini berupa kemampuan kewirausahaan yang bermanfaat bagi masyarakat Dusun Kayang Makmur. Tahapan pelaksanaan terdiri dari teori dasar kewirausahaan dan praktek pemasaran produk yang telah dibuat. Hasil dari pengabdian (pelatihan) kewirausahaan berupa pengetahuan dalam hal dasar kewirausahaan dan penerapannya.
Enthusiastic discussions on solid-state physics and materials science at SPMS2021
Authors: Dao Van-Duong , Chien Nguyen Duc , Phuong Doan Dinh , Huy Pham Thanh , Thang Phan Bach
Published: November 2022

The 12th National Conference on Solid State Physics and Materials Science (SPMS2021) gathered various notable scientists (7 plenary speakers and 34 invited speakers). Attending the conference and actively participating in the debate were more than 450 scholars with an interest in the topic. Four hundred reports were divided into five specialized sessions, including (A) physics and magnetic materials, (B) semiconductor and dielectric physics, (C) semiconductor and dielectric materials and devices, (D) biomedical materials and materials for agriculture, energy, and the environment, and (E) composite materials - metals, ceramics, and Vietnam-Korea sessions on applied physics. In addition, the Organizing Committee received numerous full-text reports that had been submitted to the Journal of Science and Technology (Vietnam Academy of Science and Technology) following a rigorous review procedure. SPMS2021 co-organized by the Vietnam Physical Society, the Vietnam Materials Research Society (V-MRS), the Institute of Physics, the Institute of Materials Science (Vietnam Academy of Science and Technology), Hanoi University of Science and Technology, Vietnam National University (VNU), Phenikaa University, and Can Tho University was held on 13 – 15 August 2022 in Can Tho City after nearly 9 months of postponement due to the COVID-19 pandemic. The conference has attracted 7 plenary speakers, 34 invited speakers, and over 450 scientists (Figure 1, Table 1, and Table 2) 1. It is not only a sizable and esteemed scientific conference that draws the interest of the Vietnamese scientific community, but it is also a venue for getting together, exchanging ideas, and disseminating the most recent advancements in the SPMS sector. Since 1995, it has been conducted continuously every two years. Many scientists are generally interested in the domains of solid-state physics and materials science, which have a wide range of activities and exceptional accomplishments in both basics and applications in Vietnam.
Sağlıklı ve İshalli Buzağılarda İndirekt Osilometrik Yöntemle Ölçülen Kan Basıncı Değerlerinin Karşılaştırılması
Authors: DENİZ Ömer , EKİNCİ Gencay , ÇİTİL Mehmet
Published: November 2022

Kan basıncı, kardiyovasküler sistem fonksiyonunun değerlendirilmesi için ölçülmesi gereken önemli bir parametre- dir. Çiftlik hayvanı hekimliğinde kan basıncının ölçülmesi rutinde yaygın olarak kullanılmamaktadır. Oysaki ishal nede- niyle oluşan; periferal dolaşım bozukluğu, hipovolemi ve kollaps buzağıların kan basıncı değerlerinde anormalliklere sebep olabilir. Ayrıca, kan basıncı değerleri ishal ve çeşitli enfeksiyonlara bağlı olarak gelişen sepsis, SIRS ve septik şok gibi buzağılarda genel durum bozukluğuyla seyreden durumlarınteşhis ve prognozun tahmin edilmesinde yardımcı bir faktör olabilir. Bu araştırmada; indirekt osilometrik yöntem ile sağlıklı ve ishalli buzağılardan elde edilen kan basıncı [sistolik kan basıncı (SKB), diyastolik kan basıncı (DKB) ve ortalama arter basıncı (OAB)] değerlerinin karşılaştırılması amaçlandı. Bu amaçla, 20 sağlıklı ve 20 ishalli olmak üzere toplam 40 adet buzağının kan basıncı değerleri non-invaziv osilometrik kan basıncı cihazı ile 3 farklı bölgeden (sağ ön ekstremite, sol ön ekstremite ve kuyruk kökü) ölçüldü. İshalli buzağılardan sağ ön ekstremite, sol ön ekstremite ve kuyruk kökünden kan basıncı ölçümleri elde edildi [Sağ ön ekst- remite; SKB (mmHg) (87.07±27.32), DKB (mmHg) (100.33±26.55), OAB (mmHg) (95.07±21.02), Sol ön ekstremite; SKB (mmHg) (82.80±22.50), DKB (mmHg) (94.47±20.62), OAB (mmHg) (90.27±19.69), kuyruk; SKB (mmHg) (56.73±12.38), DKB (mmHg) (75.60±12.21), OAB (mmHg) (91.20±22.73)] değerleri elde edildi. Sonuç olarak, osilomet- rik kan basıncı ölçme işlemi klinik pratikte hızlı ve kullanışlı bir tekniktir. İshalli buzağıların sağ ön ekstremitelerinden ölçülen SKB (87.07±27.32 mmHg) ve OAB (95.07±21.02 mmHg) değerleri, sağlıklı buzağılardan (SKB; 158.80±13.12 mmHg, OAB; 123.67±21.70 mmHg) istatistiksel olarak anlamlı düzeyde düşük bulundu (P<0.001). Bu araştırmadan elde edilen bulgular ishale bağlı olarak gelişen düşük arteriyel kan basıncı gibi hayati tehdit eden durumlarda kan ba- sıncını artırmaya yönelik terapötik ajanların tedavi stratejileri arasında yer alması gerektiğinin önemini göstermektedir.
Formation of career strategies for students with health limitations and disabilities at the stage of vocational training at university
Authors:   Vyatka State University, Volchenkova Elena V. , Voronina Olga A. ,   Vyatka State University, Tursenev Sergey A. ,   Saint Petersburg University of State Fire Service of Emercom of Russia, Bugaychuk Tatiana V. ,   Yaroslavl State Pedagogical University named after K.D. Ushinsky, Koryakovtseva Olga A. ,   Yaroslavl State Pedagogical University named after K.D. Ushinsky
Published: November 2022

Introduction. The successful construction of career strategies is an important mechanism for social integration for people with health limitations (HLs) and disabilities. However, many university graduates with HLs and disabilities cannot find a job or do not make any attempts to provide themselves with employment. The purpose of the study: to develop, scientifically substantiate and test the content of the program for formation of career strategies for university students with HLs and disabilities. Materials and methods. The survey involved 117 people – 79 graduate students and 38 graduates with HLs and disabilities of partner universities of the Resource Educational and Methodological Center of Vyatka State University (Russian Federation). The significance of the obtained changes in the control and experimental groups was checked using the U-Mann-Whitney and Fishers statistical criteria. Results. The results of the survey indicate that the students and graduates with HLs and disabilities note that they have an insufficient level of development of competences necessary for finding a job, employment and performing professional activities. The program "Youth Career Strategies" was developed and tested. As a result, significant changes were recorded in such parameters as career planning (Uemp=21; р≤0,01), business communications (Uemp=27; р≤0,01), overcoming crises when career building (Uemp=29; р≤0,01) and entrepreneurial skills (Uemp=15; p≤0,01) after implementation of the author's program in the experimental group. Conclusion. It was found out that effectiveness of formation of career strategies for students with HLs and disabilities at the stage of vocational training at university improves after implementing the program, the content of which includes formation of value-motivational foundations for building career strategies; development of soft skills and expansion of ideas about possibilities of entrepreneurial career building.
Pelatihan Memulai Usaha Untuk Berwirausaha Cara Merintis Dan Memulai Suatu Bisnis Pada Remaja Putus Sekolah Di Desa Kerinjing Kabupaten Ogan Ilir
Authors: Apriani Deassy , Subardin Muhammad , Teguh Muhammad , Andaiyani Sri , Imelda Imelda
Published: November 2022

Kegiatan Pengabdian Kepada Masyarakat merupakan salah satu Tri Dharma Perguruan Tinggi yang harus dilaksanakan. Pada kesempatan kali ini, kegiatan pengabdian tahun 2020 dilakukan di salah satu Desa Binaan Fakultas Ekonomi Universitas Sriwijaya yakni Desa Kerinjing yang terletak di Kecamatan Tanjung Raja Kabupaten Ogan Ilir. Kegiatan pengabdian kali ini mengangkat tema mengenai kewirausahaan bagi remaja yang putus sekolah atau menganggur. Mereka akan diberikan pelatihan untuk memulai berwirausaha baik cara merintis dan memulai suatu bisnis. Sulitnya lapangan kerja saat ini, membuat kita untuk melaksanakan kegiatan ini, sehingga masyarakat desa khususnya yang putus sekolah ataupun menganggur dapat memiliki ilmu untuk memulai usaha baik dari segi permodalan, pengaturan keuangan maupun strategi untuk memulai usaha.
Sosialisasi Administrasi Posko Covid-19 di Kelurahan Parangjoro
Authors: Nurhayati Siti Aisyah , Pangesti Sri Suratmi Aji
Published: November 2022

Abstract: Virus Covid-19 yang saat ini telah tersebar luas di berbagai negara salah satunya Indonesia. Hal tersebut menjadi momok bagi kalangan masyarakat dan menjadikan mereka lebih waspada dalam beraktifitas sehari-hari agar tidak terpapar virus Covid-19. Tujuan dari kegiatan pengabdian pada masyarakat ini adalah untuk memberikan sosialisasi dan edukasi mengenai gejala-gejala apa saja yang ditimbulkan, cara penyebaran atau penularan virus tersebut, cara pengobatan serta langkah-langkah pencegahan virus Covid-19. Dalam kegiatan ini langkah awal yang harus dilakukan adalah membuat poster mengenai Covid-19 dan di letakkan di tempat yang banyak di jumpai orang atau warga sekitar misalnya seperti pos kamling, gapura dan mading kelurahan Parangjoro. Lalu membantu sosialisai yang di lakukan oleh Babinsa, Bidan dan rekan-rekannya secara offline di kelurahan. Setelah itu mendata warga yang terkena Covid-19 dan membagikan maker, handsanitizer serta tempat cuci tangan di pos kampling daerah Parangjoro. Hasil dari kegiatan pengabdian ini adalah agar masyarakat lebih mengerti dan menerapkan cara pencegahan virus Covid-19 dan mulai melakukan kebiasaan perilaku hidup bersih dan sehat sebagai upaya dalam pengurangan dan pemutusan rantai penyebaran virus Covid-19.
Effect of C677T methylenetetrahydrofolate reductase gene polymorphism on plasma homocysteine levels in ethnic groups.
Authors: Gašparovič J , Rašlová K , Bašistová Z , Zacharová M , Wsólová L , Avdičová M , Blažíček P , Lietava J , Siváková D
Published: November 2022

The objective of this study was to examine plasma homocysteine levels and C677T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism in two ethnic groups from Slovakia. The samples consisted of general Slovak-Romany population (68 men and 81 women) from Southwestern Slovakia and the Slovak-Caucasians (174 men and 177 women) who participated in the CINDI project. The homocysteine levels were examined by HPLC, the analysis of MTHFR genotypes was done by PCR. The Slovak-Romany men (12.0±5.6 (S.D.) μmol/l) and women (9.2±2.6 μmol/l) have significantly lower plasma homocysteine levels (p<0.024 and p<0.00001) when compared to Caucasians (13.3±5.1 μmol/l in men and 11.3±4.3 μmol/l in women). The genetic equilibrium is assumed for the gene frequencies of the MTHFR polymorphism in both samples. The distribution of MTHFR genotypes did not differ between the two populations (TT 13 vs. 10.6 %; CT 46.6 vs. 41.7 %; CC 40.4 vs. 47.7%, zeta2 = 2.315, df=2, ns). The effect of MTHFR genotypes on homocysteine levels was not confirmed in the Slovak-Romanies and TT homozygosity significantly increased plasma homocysteine levels only in Slovak-Caucasians (11.5±4.4 mmol/l, ns; vs. 14.8±4.8 mmol/l, p<0.002, respectively). To our knowledge, this is the first epidemiological study in the Romany population examining distribution of the MTHFR genotypes and their effect on homocysteine levels. Further studies are needed to establish the variety of cardiovascular risk factors among Romanies in order to evaluate the significance of particular factors.
Autoimmune endocrinopathies in the area of HLA antigen expression.
Authors: Hrdá P , Šterzl I , Matucha P , Korioth F , Kromminga A
Published: November 2022

The HLA allelic frequency was determined in three groups of autoimmune endocrinopathies: A) 30 patients with autoimmune thyroiditis, B) 20 patients with polyglandular activation of autoimmunity, and C) 10 patients with the autoimmune polyglandular syndrome type II. The groups were defined by the clinical state and serological parameters. Healthy blood donors of Caucasian population from the US database of HLA frequencies served as the controls. In group A, a higher occurrence of HLA-A24 (21.7 %) was found as compared to group B (5.0 %) and to the controls (8.5 %), of HLA-B27 (15.0 %) and of HLA-DR-11 (20 %) as compared to the controls (4.2 % and 8.5 %). In group B, a higher occurrence of HLA-A3 (25.0 %) was found as compared to group A (10 %) and to the controls (11.8 %), and of HLA-B8 (22.5 %) as compared to group A (8.3 %) and to the controls (8.6 %). In this group the occurrence of HLA-DR3 (30.0 %) was higher as compared to group A (10.0 %) and to the controls (9.8 %) and of HLA-B8 (30.0 %) as compared to group A (8.3 %) and to the controls (8.6 %). Genetic markers indicate a similarity of groups B and C. Patients in these groups could be at different stages of the same disease, however, some distinctions between them lead us to consider the possibility whether different epigenetic factors could extend the difference between these groups in the course of clinical development.
Adiponectin and its role in the obesity-induced insulin resistance and related complications.
Authors: Haluzík M , Pařízková J , Haluzík MM
Published: November 2022

It is now generally accepted that adipose tissue acts as an endocrine organ producing a number of substances with an important role in the regulation of food intake, energy expenditure and a series of metabolic processes. Adiponectin is a recently discovered protein produced exclusively by adipocytes. A number of studies have shown that obesity, insulin resistance and atherosclerosis are accompanied by decreased adiponectin levels and that adiponectin replacement under experimental settings is able to diminish both insulin resistance and atherosclerosis. The aim of this review is to summarize the current knowledge about the physiology and pathophysiology of adiponectin and to discuss its potential in the treatment of insulin resistance and atherosclerosis.
The Distinction between Real Rights and Personal Rights in the Deeds Registration System of South Africa – Part Two: Pragmatic Distinction between Real Rights and Personal Rights
Authors: Badenhorst P. J.
Published: November 2022

The second part of this article deals with the pragmatic approach of the South African courts to determine whether a right is real and, therefore, registrable in the deeds registry. The courts use a two-fold test to distinguish between real and personal rights, namely the subtraction from the dominium test and the intention test. It is indicated that the first test focuses on the impact of the right under investigation upon ownership while the second test focuses on the intention of the parties regarding the nature of the right when it was created. The application of the subtraction from the dominium test by the courts is discussed against the backdrop of a newly suggested classification of entitlements of ownership of land that are relevant within the context of the registrability of real rights. It is concluded that the common law distinctions between personal and real rights, and between ownership and limited real rights, still provide a solid conceptual basis in post-apartheid South African property theory.
Women’s Fiction in Postfeminist France: Léonora Miano, Camille Laurens, and Chick-Lit or Romances urbaines
Authors: Holmes Diana
Published: November 2022

Women make up a significant majority of fiction readers, in France as elsewhere, and the novel has long been – and remains – a widely shared medium that both reflects and reflects on gender norms and their effects on women’s lives. My paper examines three contemporary female-authored novels covering the spectrum from ‘literary’ to popular fiction, each of which might be described as a postfeminist story for a postfeminist France. The texts are: Camille Laurens’ Celle que vous croyez (2016); Marie Vareille’s Je peux très bien me passer de toi (2015); Léonora Miano’s Blues pour Élise (2010). My analysis asks in what ways the contemporary ‘women’s novel’ reflects postfeminist culture, in its negative sense as a market-oriented co-optation of feminist aims and achievements but also in its more positive sense, as a new stage in feminist struggles. To what extent can pleasurable fictions not only acknowledge the realities of a postfeminist climate, but also question and challenge them?
Trace Element Zinc Deficiency Affects Male Reproduction and Central Nervous System: An Overview
Authors: Swati Singh , Kanwar Yukti , Nair Neena
Published: November 2022

Zinc a micronutrient is a critical component essential for health. Its deficiency has affected millions of people worldwide leading to morbidity as well as mortality. Deficiency can be due to several factors – poor bioavailability, impairment in absorption as well as digestion, excess loss of zinc, stress, genetic disorders and dysfunction in transporters. Male reproductive organs are affected as evident by degeneration in testes, prostate and sperms consequently leading to infertility. Functional impairment of central nervous system due to zinc deficiency has been reported. Further studies are required to understand the role of zinc with reproductive events as well as in central nervous system as insufficiency may be a causative factor for health related problems.
Identification of Potential Inhibitor Targeting InhA, Molecular Docking, ADMET, Molecular Dynamic Simulation and Antibacterial Activity of Thiazolidinone Derivatives: A Computational Approach
Authors: Rosy P. Jacquline , Jas M. Jebastin Sonia , K Santhanalakshmi , Kumar Shanmugam Venkat , A Prabhakaran
Published: November 2022

This study was performed to examine molecular docking of newly synthesised thiazolidinone compounds and discover potential InhA inhibitors. MIC screening produced thiazolidinone derivatives for Staphylococcus aureus illness. KBr pellet FT-IR spectra were collected on a Thermo Nicolet AVATAR-330 spectrometer. Bruker obtained 400 MHz 1H spectra of all chemicals in DMSO-d6. Five 4 thiazolidinone derivatives:4-(4-oxo-2-phenylthiazolidin-3yl)amino)benzyl)oxazolidin-2-one(8), ((2-(4 chlorophenyl)-4oxothiazolidin-3yl)amino)benzyl)- oxazolidin-2-one(9), ((2-(4-fluorophenyl)-4-oxothiazolidin-3 yl)amino)benzyl)oxazolidin-2-one(10), 4-(4-((4-oxo2-(p-tolyl)thiazolidin-3yl)amino)benzyl)oxazolidin-2-one(11) and 4-(4-((2-(4 methoxyphenyl)-4-oxothiazolidin3yl)amino)benzyl)oxazolidin-2-one(12) docked due to its vast biological usefulness. Molecular docking, ADMET, TOPKAT Toxicity, and molecular dynamic simulation were used to estimate drug-likeness for 1QG6. MIC screening of synthesised thiazolidinone derivatives against Staphylococcus aureus through disc diffusion. Molecular docking studies examining the inhibitory effect of produced substances suggest testing for MIC antibacterial activity. Compound 12's antibacterial activity against Staphylococcus aureus is compared to Ampicillin and Cefixime. Compound 12 is utilised as an alternate medication for Staphylococcus aureus
Methodical Analysis of an Absolute Efficacious Ayurveda Medicine-- Amruthotharam
Authors: Manish Kumar Gupta , Ketaki Dhane , Birendra Shrivasttva , Supriya Hyam , Sujit Nagare
Published: November 2022

Amruthotharam/Amrutottaram Kashayam is one of such preparation which takes care of metabolic disorder through inflammation. The formulation composed of three ingredients-- Tinospora cordifolia, Terminalia chebula and Zingiber officinale. Amrutottaram acts by treating indigestion and neutralization of AMA, thereby helps reduce inflammation and fever by virtue of its immune-modulatory function providing ingredients. The antiinflammatory properties prove to be significant in an array of pathologies like fevers, swelling, systemic inflammation or local inflammations, painful pathologies associated with muscular stiffness, neurogenic pain and thereby useful in any pathology pertaining to any system. The metabolic syndrome is a group of risk factors that together enhance chance of developing cardiovascular disease. The dried drugs were extracted separately by soxhlet extraction process. The present work involved the detailed study of drugs in dried form which can be used in routine analysis of drug. As, the formulation contains Terminalia chebula in major amount, gallic acid was considered as marker compound. The formulation was quantified for the content of gallic acid by HPLC method.
Biochemical Performance of Cirrhinus cirrhosus Fingerlings after Soya Chunk and Almond Supplementation
Authors: R Rajeswari , S. Vijayakumar
Published: November 2022

The purpose of the study was to investigate how Cirrhinus cirrhosus fingerlings responded biochemically to the addition of soy chunks and almonds. Fish were divided into four groups-- Group I served as the control group, Group II was given the 1% soya chunk diet I, Group III was given the 1% almond diet II, and Group IV was given the 1% combined diet (1: 1 ratio of Diet I and Diet II). Overall, it can be said that providing Cirrhinus cirrhosus with Soya Chunk, Almond, or Soya Chunk + Almond supplements has a considerable impact on the species' biochemical makeup and growth performance. Dietary benefits are directly correlated with the length of supplementation. In comparison to control, other diets, and 15 days of diet supplementation, the combined diet (Soya Chunk + Almond) had a significant impact on growth performance and biochemical composition at 30 days of supplementation. The findings of this study indicated that the optimal nutritional supplements for fingerling Cirrhinus cirrhosus is a mixed diet.
Yogic Practices and Sinusitis Risk Factors in Adult Men
Authors: M Sivaraman , S Murugesan
Published: November 2022

For the random group experimental investigation, 30 sinusitis adult males aged 35 to 45 were randomly recruited from Chennai and allocated into two groups of 15 each. Yogic activities were anticipated to reduce sinusitis patients' pulse rate and anxiety compared to the control group. Before the training programme, Groups A and B were pre-tested on the dependent variables. Group A practised Yogic techniques and Group B (Control) rested actively. After eight weeks, A and B were retested on the same dependent variables. ANCOVA was used to compare experimental and control groups. Yogic techniques lowered adult men's pulse rate and anxiety with 0.05 confidence. Yoga helps older males manage pulse rate and anxiety
Airway management with novel intubating laryngeal tubes has no influence on cerebral oxygenation in cardiac surgery patients: A prospective observational study
Authors: Kriege Marc , Rissel René , Heid Florian , Ott Thomas , Beyrouti Hazem El , Hotz Eric
Published: November 2022

Background

A laryngeal tube is often used as an alternative to intubation with direct laryngoscopy during cardiopulmonary resuscitation. However, in a study with piglets undergoing simulated cardiac arrest, reduced carotid artery blood flow was associated with the insertion of different supraglottic airway devices, such as a laryngeal tube. Limited by its construction, secondary tracheal intubation through a laryngeal tube was difficult or impossible in contrast to a second generation laryngeal mask. The new disposable intubating laryngeal tube with suction (iLTS-D®) seems to facilitate tracheal intubation. We hypothesized that iLTS-D, when inflated to the recommended air volume, does not reduce cerebral oxygenation in patients with cardiovascular diseases undergoing elective cardiac surgery.

Methods

This single-center prospective, controlled observational study was approved by the local ethics committee (Ethical Committee No. 2018-13716). Forty adult patients undergoing elective cardiac surgery requiring tracheal intubation were included in this study. The exclusion criteria were age <18 years and a high risk of aspiration, inability to consent, height <155 cm, or pregnancy. Prior to insufflation and deflation of the cuffs, we performed cerebral oximetry via near-infrared spectroscopy. The primary outcome was a significant reduction in NIRS in the context of the preinduction baseline value after inflation of the cuffs with the recommended air volume, defined as a ≥25% decrease from baseline or an absolute value ≤ 50%. The secondary endpoints were differences in time points, insertion success rates, and complications.

Results

There was no significant reduction in cerebral oximetry after inflation with the recommended cuff volume and an initially measured cuff pressure of >120 cmH2O. Overall, tracheal intubation was achieved in a median of 20 s [interquartile range 15-23 s] and enabled sufficient ventilation and tracheal intubation through the iLTS-D in all patients. Traces of blood on the cuffs (after removing the iLTS-D) and a sore throat (evaluated 2 h after removing the tracheal tube) were observed in one patient.

Conclusion

Our results showed no association between the insertion of the iLTS-D and reduced cerebral oxygenation in patients undergoing elective cardiac surgery.

Trial registration

ClinicalTrials.gov, NCT03942809.
Application of stem cells combined with biomaterial in the treatment of intervertebral disc degeneration
Authors: Liu Zongtai , Bian Yuya , Wu Guangzhi , Fu Changfeng
Published: November 2022

As the world population is aging, intervertebral disc degeneration (IDD) is becoming a global health issue of increasing concern. A variety of disc degeneration diseases (DDDs) have been proven to be associated with IDD, and these illnesses have significant adverse effects on both individuals and society. The application of stem cells in regenerative medicine, such as blood and circulation, has been demonstrated by numerous studies. Similarly, stem cells have made exciting progress in the treatment of IDD. However, due to complex anatomical structures and functional requirements, traditional stem cell injection makes it difficult to meet people’s expectations. With the continuous development of tissue engineering and biomaterials, stem cell combined with biomaterials has far more prospects than before. This review aims to objectively and comprehensively summarize the development of stem cells combined with contemporary biomaterials and the difficulties that need to be overcome.
Quantitative analysis of Robertsonian chromosomes inherited by descendants from multiple Rb heterozygotes of Mus m. Domesticus
Authors: Ayarza Eliana , Cavada Gabriel , Arévalo Tamara , Molina Alam , Berríos Soledad
Published: November 2022

Robertsonian translocation is the most common chromosomal rearrangement in mammals, and represents the type of chromosomal change that most effectively contributes to speciation in natural populations. Rb translocations involve double-strand DNA breaks at the centromere level in two telocentric chromosomes, followed by repair ligation of the respective long arms, creating a metacentric Rb chromosome. Many different chromosomal races have been described in Mus musculus domesticus that show reduced chromosome numbers due to the presence of Rb metacentric chromosomes. The crossroads between ancestral telocentrics and the new metacentric chromosomes should be resolved in the meiotic cells of the heterozygote individuals, which form trivalents. The preferential segregation of metacentric chromosomes to the egg during female meiosis I has been proposed to favor their fixation and eventual conversion of a telocentric karyotype to a metacentric karyotype. This biased segregation, a form of meiotic drive, explains the karyotype changes in mammalian species that have accumulated Rb fusions. We studied and compared the number of Rb chromosomes inherited by the offspring of multiple Rb heterozygous of M. domesticus in reciprocal crosses. We did not find that the Rb chromosomes were inherited preferentially with respect to the telocentric chromosomes; therefore, we found no evidence for the meiotic drive, nor was there a random distribution of Rb chromosomes inherited by the descendants.
Anticancer-active 3,4-diarylthiolated maleimides synthesis via three-component radical diarylthiolation
Authors: Wang Limei , Li Zhuo , Ma Zhehan , Xia Kedi , Wang Wenyu , Yu Wenchang
Published: November 2022

Herein, we report an efficient and simple copper-catalyzed oxidative diarylthiolation of maleimides with sulfur powder and aryl boronic acids, in which S powder was used as a substrate and internal oxidant. The corresponding double C-S bonds coupling products were obtained in moderate to high yields under a simple catalytic system. Mechanistic studies indicated that copper-catalyzed radical thiolation of aryl boronic acids with S powder, and the resulting arylthiyl underwent radical addition with double bonds of maleimides.
Multisystem immune-related adverse events due to toripalimab: Two cases-based review
Authors: Chen Yanran , Chen Yulan , Xie Jingyi , Liu Dongzhou , Hong Xiaoping
Published: November 2022

Immune checkpoint inhibitors (ICIs) have significantly improved the survival of patients with advanced tumors. However, immune-related adverse events (irAEs) caused by ICIs, especially high-grade irAEs, are of growing concern. High-grade multisystem irAEs due to toripalimab, a programmed cell death-1 (PD-1) inhibitor, have been rarely reported. Two patients with malignant metastatic tumors were treated with anti-PD-1 immunotherapy. However, both patients developed high-grade multisystem irAEs based on myocarditis, with chest discomfort and malaise as the main clinical manifestation. Both patients had an elevation of cardiac enzymes, abnormal electrocardiography and left ventricular wall motion. Patient 2 was also diagnosed with organizing pneumonia. Immunotherapy was suspended. High-dose intravenous methylprednisolone was immediately initiated. The patients’ symptoms were significantly relieved in a short period of time. Immunosuppressants were discontinued at the 6th month follow-up in patient 1 without relapse. However, patient 2 was lost to follow up due to financial reasons. To the best of our knowledge, this is the first report regarding ICI-associated myocarditis-pneumonia due to toripalimab, indicating the significance of early recognition and management of high-grade multisystem irAEs in clinical practice.
The role of lacteal integrity and junction transformation in obesity: A promising therapeutic target?
Authors: Xia Qingsong , Dong Hui , Guo Yujin , Fang Ke , Hu Meilin , Xu Lijun , Lu Fuer , Gong Jing
Published: November 2022

Lacteals are the central lymphatic vessels in the villi of the small intestine and perform nutrient absorption, especially dietary lipids, and the transportation of antigen and antigen-presenting cells. Remodeling, proliferation, and cell-cell junctions of lymphatic endothelial cells (LECs) in lacteals are the basis of the maintenance of lacteal integrity and dietary lipid absorption. Normal lipid absorption in the diet depends on sound lacteal development and proliferation, especially integrity maintenance, namely, maintaining the appropriate proportion of button-like and zipper-like junctions. Maintaining the integrity and transforming button-to-zipper junctions in lacteals are strongly connected with obesity, which could be regulated by intestinal flora and molecular signalings, such as vascular endothelial growth factor C-vascular endothelial growth receptor 3 (VEGFC-VEGFR3) signaling, Hippo signaling, Notch signaling, angiopoietin-TIE signaling, VEGF-A/VEGFR2 signaling, and PROX1. This manuscript reviews the molecular mechanism of development, integrity maintenance, and junction transformation in lacteal related to obesity.