bluuebunny/crossref_metadata_2025 huggingface dataset:
Miastenia Gravis: uma análise crítica dos métodos diagnósticos e condutas terapêuticas
Authors: Luz Adrianne Rocha , Brandão Ana Júlia Lôbo , Spínola II Carlos Arthur Laranjeira , Nagao Guilherme Massanori , Moura Letícia Torres , Souza Valentina Aguilar , Gonçalves Ana Luiza Sousa , Rocha Rafaela Rhaynara Almeida , Prado Anna Clara Alves Martins , Gomes Kleber Alves
Published: September 2022

Objetivo: Compreender os métodos diagnósticos, as formas de terapia utilizadas e recomendadas para o tratamento de pacientes portadores de Miastenia Gravis (MG). Revisão bibliográfica: Frequentemente na prática clínica o diagnóstico de MG é firmado em acordo com a história clínica do paciente, além disso é necessário também a avaliação física e outros exames específicos destinados a analisar a função neuromuscular. Por se tratar de uma doença crônica, o tratamento da MG é voltado para minimizar os sintomas e melhorar a qualidade de vida do paciente. Um dos fármacos mais utilizados na MG, principalmente para o tratamento sintomático, são os Inibidores da Acetilcolinesterase (AChE). Ademais, a timectomia é um tratamento cirúrgico recomendado principalmente para pacientes com timoma, mas também pode ser realizada em pacientes jovens com MG generalizada. Nos pacientes com sinais de ameaça à vida, como na MG grave e na Crise Miastênica (CM), beneficia-se de outras terapias associadas aos fármacos utilizados para o tratamento da MG. Considerações finais: A maximização das condutas terapêuticas da Miastenia Gravis significa prolongar a perspectiva de vida, de modo que os pacientes miastênicos possuam condições de conforto e bem-estar.
A rare complication after vestibular schwannoma surgery: Neurogenic pulmonary edema
Authors: Ravindran Pawan Kishore , Kunst Dirk , Waterval Jerome , Hovinga Koos , Temel Yasin
Published: September 2022

Background:

In our center, large vestibular schwannoma (VS) is typically managed by a planned partial resection through the translabyrinthine route. Here, we report on a rare complication of VS surgery and severe neurogenic pulmonary edema.

Case Description:

A 33-year-old male was referred to our skull-base center with a large VS. A planned partial resection was performed. The surgery was without complications and the patient showed good recovery without facial nerve dysfunction. In the evening of the 2nd day after surgery, the patient showed rapid neurological deterioration, accompanied by cardiac arrest. After the patient was resuscitated, a computed tomography (CT) was made, which showed generalized (infra- and supratentorial) brain edema and hematoma in the resection cavity. Despite rapid removal of the hematoma, there was no change in the neurological situation. The next CT scan showed a further increase of brain edema and the patient died eventually. Autopsy revealed generalized lung edema, brain edema, and Hashimoto’s thyroiditis. The pathologist diagnosed neurogenic lung edema.

Conclusion:

Neurogenic lung edema can occur on the 2nd day after surgery and induce rapid deterioration of the patient with massive brain edema.
Challenges in the pre- and post-natal diagnosis of posterior fossa cysts: A case report and review of historical evolution of descriptive terminologies
Authors: Kutty Sarvesh , Clarke Glen , Kutty Jayasree
Published: September 2022

Background:

Radiological diagnoses of posterior fossa cystic abnormalities during antenatal and postnatal periods pose significant challenges as they may have similar early imaging features. Some of the frequently described entities are arachnoid cysts and Dandy-Walker malformations. Blake’s pouch cyst is relatively underdiagnosed. The main aim of the study was to explore these diagnostic challenges in the context of various descriptive terminologies and their prognostic implications.

Methods:

We illustrate this through our case, where fetal magnetic resonance imaging (MRI) at 36 weeks gestation showed small right cerebellum without hydrocephalus or hemorrhage. Possible differential diagnoses included Dandy-Walker malformation or posterior fossa malformations, facial hemangiomas, arterial anomalies, cardiac and eye anomalies, sternal clefting, and supraumbilical raphe.

Results:

Postnatal sonography noted posterior fossa cyst without hydrocephalus in a normal term infant, who went on to develop symptomatic hydrocephalus by 15 weeks. Computed tomography brain scan confirmed large subtentorial posterior fossa cyst and extensive internal hydrocephalus. Despite emergent ventriculoperitoneal shunt insertion, head circumference continued to rise. MRI scan showed persistent cyst. Subsequently, infant underwent endoscopic fenestration of the cyst with balloon septostomy and now has an age appropriate developmental profile.

Conclusion:

There is considerable discordance between antenatal and postnatal neuroimaging findings as highlighted in our case. Diagnostic conundrum here was whether this was an arachnoid or Blake’s pouch cyst. Differentiating between posterior fossa fluid collections is crucial for management, prognosis, and parental counseling. Close postnatal follow-up is essential to avert complications due to acute hydrocephalus.
Spinal intradural solitary fibrous tumor/ hemangiopericytoma with intramedullary invasion mimicking a hemangioblastoma
Authors: Thapa Shanta , Yamahata Hitoshi , Okada Tomohisa , Yonenaga Masanori , Bajagain Madan , Makino Ryutaro , Hanaya Ryosuke
Published: September 2022

Background:

Solitary fibrous tumor/hemangiopericytomas (SFT/HPCs) are rare mesenchymal tumors of nonmeningothelial origin that comprises <1% of all central nervous system tumors.

Case Description:

A 45-year-old male presented with sleep apnea (apnea-hypopnea index was 17.1 events/hour) and dysesthesias of the right upper and lower extremities. The magnetic resonance demonstrated a heterogeneous intradural extra-axial C1 mass with syringobulbia and syringomyelia. The right vertebral angiography revealed a hypervascular mass (i.e., intense tumor staining). With the preoperative diagnosis of a spinal hemangioblastoma, the patient underwent tumor removal. However, intraoperative findings demonstrated that the ventral component of the tumor was intramedullary without a dural attachment. Further, the histological diagnosis was consistent with SFT/HPC (HPC phenotype). The postoperative course was uneventful, and the patient’s symptoms and the syrinxes spontaneously regressed.

Conclusion:

A 45-year-old male presented a rare spinal intradural lesion at C1 appeared to be a spinal hemangioblastoma, but proved to be SFT/HPC (HPC phenotype) with intramedullary invasion.
Primary intracranial synovial sarcoma: A case report and review of literature
Authors: Vora Tarang K. , Lath Rahul , Swain Meenakshi , Ray Amitava
Published: September 2022

Background:

Primary intracranial synovial sarcomas (PrISS) are unusual dural based mesenchymal tumors seen most commonly in the supratentorial compartment. They can mimic a spontaneous intracranial hemorrhage or a high-grade glioma on imaging.

Case Description:

A 31-year-old male presented with headache and right hemiparesis for 2 weeks. CT brain revealed a left frontal spontaneous intracerebral hemorrhage. PrISS revealed a heterogeneously ring enhancing solid cystic lesion with attachment to convexity dura. Intraoperatively, it mimicked a high-grade glioma. Histopathology report showed features of a synovial sarcoma, which was later confirmed with IHC. Classical SYT-SSX2 translocation was confirmed only on RTPCR after fluorescent in situ hybridization (FISH) was negative for same. Whole body positron emission tomography (PET-CT) did not show any extracranial tumor. Despite radiotherapy, there were recurrence and tumor progression at 6 months and the patient succumbed 11 months later.

Conclusion:

PrISS is an unusual aggressive intracranial neoplasm that carries a worse prognosis when compared nonintracranial synovial sarcomas. Molecular cytogenetics (FISH and RTPCR) are essential for confirming the diagnosis, though FISH seems to have a lower sensitivity and can yield false negative results as was noted in this case.
Dorsal vertebral body tumor and non-compressive quadriparesis – A rare case report of a phosphaturic mesenchymal tumor
Authors: Bhatjiwale Mrudul Mohinish , Chandrachari Komal Prasad , Kannan Subramanian
Published: September 2022

Background:

Phosphaturic mesenchymal tumors cause renal phosphate wasting leading to hypophosphatemia manifesting as bone pain and fractures. About 95% of these tumors involve the extremities and the appendicular skeleton, with spinal tumors being exceedingly rare. We describe a case of non-compressive quadriparesis, caused by a thoracic vertebral body phosphaturic mesenchymal tumor (PMT).

Case Description:

A 34-year-old gentleman presented with a 3-year history of gradually progressive quadriparesis, predominantly involving proximal muscles. Magnetic resonance imaging neither showed evidence of compressive lesions nor myelopathy. On routine biochemistry, he was found to have hypophosphatemia and phosphaturia, with serum phosphorus levels of 1.84 mg/dl, and fractional excretion of phosphorus >5%. A DOTATOC positron emission tomography scan suggested the possibility of a PMT in the D10 vertebral body with a corresponding hyperdense/sclerotic focus on non-contrast computed tomography. After instituting phosphate replacement therapy and complete surgical excision of the hyperdense focus, he made a full neurological recovery. His phosphate levels normalized without the need for supplements. Histopathological examination showed spindle cells with positive staining for Vimentin, a mesenchymal cell marker. At 5 years of follow-up, the patient continues to be asymptomatic with a full return to normal function and no residual weakness.

Conclusion:

PMTs involving the spine are a rare reversible cause of non-compressive quadriparesis. Early diagnosis and excision of the lesion correct the hypophosphatemia and result in complete neurological recovery.
Burr hole on polyetheretherketone cranioplasty for the management of chronic subdural hematoma: A case report
Authors: Marrone Salvatore , Costanzo Roberta , Scalia Gianluca , Iacopino Domenico Gerardo , Nicoletti Giovanni Federico , Umana Giuseppe Emmanuele
Published: September 2022

Background:

In rare cases, chronic subdural hematoma can be a complication following cranioplasty implantation. Therefore, it can develop spontaneously or after a trauma in the underlying site of a duroplasty and represent, if compression of the brain structures, a life-threatening condition. In case of a patient with cranioplasty in polyetheretherketone (PEEK), performing a burr hole on prosthesis can represent, although unusual, an effective and safe technique for evacuation of the chronic subdural hematoma, avoiding the need to remove the prosthesis itself. Nevertheless, a rare and insidious prosthesis infection can occur, even after years.

Case Description:

A 54-year-old male patient, following severe traumatic brain injury, underwent a right hemispheric decompressive craniectomy associated to acute subdural hematoma evacuation and, subsequently, a PEEK cranioplasty implant with polytetrafluoroethylene (PTFE or Gore-Tex) duroplasty. About 10 years later, he experienced worsening headache with sensory alterations; therefore, he underwent a brain computed tomography scan documenting a right hemispheric chronic subdural hematoma (cSDH), expanding in subsequent radiological examinations. Because of symptoms’ worsening, he underwent cSDH evacuation through a burr hole centered on the parietal region of the PEEK prosthesis, associated with mini-reopening of duroplasty. Two years after the procedure, he went to the emergency department because of the appearance of a serum-purulent material drained from the surgical site. He underwent cranioplasty removal and then started a targeted therapy to treat a triple surgical site infection, often unpredictable and totally accidental.

Conclusion:

Based on the literature evidence, performing a burr hole on a cranial prosthesis in bone-like material such as PEEK represents a surgical procedure never performed before and in our opinion could, in selected cases, guarantee the cSDH evacuation and the treatment of intracranial hypertension, avoiding the cranioplasty removal, although there is a risk of even late surgical site infection.
Current issues on digitalisation of controls in the financial and budgetary sphere
Authors: Isaev E. A.
Published: September 2022

Digitalization of control activities is a prerequisite for quality implementation of state financial control in the Russian Federation and effective interaction between all control bodies in order to prevent and combat violations in the financial and budgetary sphere. The article is devoted to the idea of introducing a new “digital control”. This solution is based on transferring the processes of interaction between control bodies and objects to a digital environment, which will allow to conduct a digital dialogue. The possible results of the departmental project in terms of the Federal Treasury control unit are considered. Current actions of government authorities in control (supervision) and oversight in the financial and budgetary sphere, as well as measures taken by the Federal Treasury in this area were analysed. It is concluded that digital transformation has in fact become a necessary condition for increasing the efficiency of control in the financial and budgetary sphere.
The impact of self-isolation on the socio-psychological state of a person: research results
Authors: Ahmadinurov R. M. , Ispulova S. N. , Oleynik E. V. , Bochkarev I. V. , Vinogradova E. D.
Published: September 2022

Based on the analysis of the results of the survey conducted by the authors through a service such as Google Forms, some aspects of the impact of the COVID-19 coronavirus pandemic on the socio-psychological state of a person are considered. The sample of respondents can be described as spontaneous. The age of respondents in the range from 14 to 71 years, these are residents of different states, localities, differing in the nature of leading activities and social status. However, the results of the study demonstrate that place, age, status and other characteristics are not crucial in terms of socio-psychological well-being during the pandemic. Among the main problems faced by the population in the conditions of the pandemic are limited contacts and movement, difficulties with the organization of school-age children’s studies, loss of work and reduced income, fear for their health and the health of loved ones.
Socio-psychological status in the family and psychological culture of the mother of a child with visual impairment
Authors: Svyatkina A. N. , Tsvetkova N. A.
Published: September 2022

The article presents the results of testing the hypothesis about the presence of destructive tendencies in the socio-psychological status of mothers in families raising children with visual impairments, as well as about the disharmonious nature of their psychological culture. Mothers from 48 families took part in the experiment. Negative trends such as: excessive importance of the mother’s role in the family circle; estrangement from the spouse; intimacy with the child to the detriment of intimacy with the spouse were found. The following are noted: a high level of psychological culture of mothers in terms of the “strength of aspiration” parameter and an average level in terms of the “degree of their realization” parameter, as well as some contradictions in the indicators of sensitivity, emotional acceptance and behavioral manifestations of mothers in relations with their children, which in general gave reason to define their psychological culture as “disharmonious”.
Values and basic beliefs of working and non-working students
Authors: Tsvetkova N. A. , Lagvilava K. E.
Published: September 2022

The article is prepared on the basis of empirical data obtained from a sample of senior students divided into two groups – a group of working and a group of non-working students. They studied and compared social values and individual priorities, as well as basic beliefs. It is shown that both student samples are generally characterized by the same average overall level of social values (3.9 points out of 7 possible) and a low overall level of individual priorities, although it is higher for working students (2.1 vs. 1.8 points). The priority of social values over individual values was found in both groups. Intergroup differences in the value of “power” are established: its indicator is higher among working students; non-working students attach more importance to independence. Working students, in comparison with non-working students, have a higher individual significance of conformity and achievements. Students of both groups have a high level of conviction in their own worth and luck, but the world seems to them more unfair than fair. Significant intergroup differences in none of the five basic beliefs were revealed.
Psychological factors of the effectiveness of competitive activity in professional skills
Authors: Tymchikov A. Yu.
Published: September 2022

The results of psychological studies of the factors of the effectiveness of competitive activity in professional skills are presented. The psychological content of this activity, its connection with competitive activity is revealed. The main method of empirical research of psychological factors of the effectiveness of competitive activity in professional skills was a comparative analysis of highly and poorly effective activities, as well as personal and professional qualities of their subjects. For this purpose, the survey of winners and prize-winners of professional skills competitions, as well as those participants who performed unsuccessfully, was used. The main psychological determinants that ensure successful performance at professional skill competitions with a high level of instrumental readiness are identified. The main psychological reasons for unsuccessful performances are identified - excessive independence with insufficient experience of psychological training; insufficient command of psychological technologies of self-action; low need for achievements, blurred fuzzy image of “I am the winner”; inadequate (overestimated and understated) self-esteem; unproductive reflection, low level of reflective culture; insufficient level of development of the main personal and professional qualities; uncertainty.
Business management in conditions of the Russian economy digitalization
Authors: Zyablikova O. A.
Published: September 2022

Digitalization as a concept of economic activity based on digital technologies is gaining more and more popularity and is being introduced into various spheres of life. In the global aspect, digitalization covers the economies of countries of almost the whole world, which determines the triggers for the formation of their development strategies in the long term. Living in the age of digitalization, one cannot but say about it as a new phenomenon that is becoming new for the development of the state, business structures and society as a whole. The purpose of the study was to study the theoretical foundations of the digital economy and develop recommendations for the introduction of a new digital product in the activities of the organization. To achieve this goal, the method of formalization, observation and economic experiment was applied. The main results of the study were the obtained new knowledge about the digital economy, as a result of the analysis of various approaches to the definition of the digital economy from the standpoint of the sectoral approach. The place and role of Russia in the development of global digitalization processes has been determined. The opinions of scientists and business representatives regarding the opportunities and risks of digitalization for business structures, financial institutions, and the social sphere are presented. The theoretical consideration of the essence of the digital economy has received a significant practical focus. This concerns the promotion of digital products of large companies in the regions. On the example of the Penza oil and gas organization, a project for the introduction of a new digital product was considered, a hierarchical structure of work was described, and a rationale for the economic feasibility of the project was given. The further direction of the research will lie in the plane of applying flexible methodologies in the design of new projects in the field of digitalization, which are currently gaining great popularity.
A Sulfamate-Tethered Aza-Wacker Cyclization Strategy for the Syntheses of 2-Amino-2-Deoxyhexoses: Preparation of Orthogonally Protected D-Galactosamines
Authors: SATHYAMOORTHI SHYAM , Paul Debobrata , Mague Joel
Published: September 2022

We present a new strategy for the assembly of protected D-galactosamine synthons. Our route uses a sulfamate-tethered aza-Wacker cyclization as a key step and commences from D-erythrono-1,4-lactone. This stands in contrast to most literature syntheses of 2-amino-2-deoxyhexose derivatives, as these generally employ glycals or hexoses as starting materials. This strategy may serve as a template for the assembly of many other 2-amino-2-deoxyhexoses with protection patterns difficult to access by conventional methods.
Effectiveness of alternative GSM therapies: "twist of fate" or natural evolution?
Authors: Orazov Mekan R. , Radzinsky Viktor E. , Dolgov Evgeny D.
Published: September 2022

The study and development of new therapies for genitourinary syndrome of menopause (GSM) remain an area of focus in modern gynecology. The relevance and need for scientific research in this area are undeniable due to the significant negative impact of GSM on patients' quality of life. At this point, however, a great deal of controversy is arising as the knowledge of the treatment of GSM-associated disorders deepens. Local hormonal therapy remains the "gold standard" for vulvovaginal atrophy treatment, but alternative therapies for GSM are launching in the pharmaceutical market. Have we got more answers? Yes. Have we got more questions? Sure. So why does the very fact of studying GMS require us to be so pedantic and focus the attention of the entire global medical community? Let's get to the bottom of this.
Change of angiogenesis in the nodular form of benign mammary dysplasia during treatment with alkaloids, flavonoids and glycosides
Authors: Pokul' Liliana V. , Chugunova Nina A. , Lebedeva Marina G. , Sorokivskii Ivan M. , Uriupina Anna P. , Solov'eva Elena A. , Utkina Anna M.
Published: September 2022

Introduction. The formation of new blood vessels is called angiogenesis. As the tumor grows, the oxygen and nutrient requirements of the abnormal cells continuously increase, and new blood vessels are formed. These processes are disrupted by angiogenesis inhibitors. Therefore, it is warranted to investigate ways to enhance the capabilities of angiogenesis inhibitors alkaloids, flavonoids, and glycosides.

Aim. To justify the extension of clinical use of alkaloids, flavonoids and glycosides (Conium maculatum and Hydrastis canadensis, Thuja occidentalis), being a part of the complex medical product Mastopol, taking into account the obtained data on the angiogenic balance in the nodular form of benign mammary dysplasia (BMD).

Materials and methods. The study included 69 volunteers divided into two groups: Group 1 included 27 patients with medical history of surgery for nodular BMD who received antiproliferative preoperative therapy with Mastopol for 12 weeks. Group 2 (comparison group), n=42, also included patients with medical history of surgery for nodular BMD but without preoperative therapy with the herbal medicine Mastopol. We studied angiogenesis markers (VEGF-A [vascular endothelial growth factor] and pVEGF-1) and immunohistochemical marker CD34 (cluster of differentiation CD).

Results. We found a significantly higher (p0.001) rate of CD34 detection on medium and small caliber vessels in the comparison group, i.e., in the patients who were not treated preoperatively with alkaloids, flavonoids, and glycosides (Mastopol), while blood supply to the nodules by the medium and small vessels was 1.4 and 1.8 times lower in the Group 1, respectively. Analysis of VEGF expression shows an increase of angiogenic promoters VEGF-A and pVEGF-1 in serum before treatment with biologically active herbal components of Mastopol in both groups. There were no statistically significant differences in vascular markers. However, a statistically significant decrease in VEGF-A and pVEGF-1 (p0.001) was noted in Group 1 after Mastopol therapy. Note the presence of a moderate direct correlation (rs=0.49) of CD34 expression with VEGF-A expression in Group 1 and rs=0.41 in Group 2, which indicated a direct relationship between angiogenesis and proangiogenic factors.

Conclusion. In addition to the proven antiproliferative, anti-inflammatory, cytokine stabilizing, analgesic, and anti-edema properties of Mastopol, the study also showed the antiangiogenic effect of the herbal drug components. Considering the decreased vascular growth in fibroadenomas during Mastopol treatment, the indications for its use in patients with fibroadenomas before the surgery can be extended. Specific immunological test to measure VEGF can be proposed as a noninvasive screening method to evaluate the effectiveness of conservative treatment in general clinical practice.
Language of Open-Air Market in North-Central Nigeria
Authors:   University of Ilorin, Nigeria, G. akuade , Atolagbe O. ,   University of Ilorin, Nigeria, Udosen E. ,   University of Calabar, Nigeria, Rafiu A. ,   University of Ilorin, Nigeria
Published: September 2022

Language plays a significant role in business, trade and commerce. Bargaining in open-air markets often involves the speech act of negotiating, compromising and manoeuvring, which could either result in conflict or persuasion of the potential buyer to patronize a seller. This article examined the sociolinguistic aspects of language use between sellers and buyers in Ipata, a popular market in Ilorin, north-central Nigeria. The call strategy, spiel, honorification, pragmatic mechanics as well as sociolinguistic style employed by vendors were observed. The objectives of the study were to: identify the number of languages used in Ipata market; investigate the factors that influence the choice of any of the languages used between sellers and buyers at a particular time; analyze their sociolinguistic and stylistic features; and discuss some of the barriers that could cause intercultural communication breakdown between sellers and buyers in a market situation.Oral interview, systematic observation and Bauman’s (2001) method of street recording were used to gather data for the study. Sixty-five people comprising thirty-six females and twenty-nine males were interviewed. The survey which spanned three months discovered that open-air markets bear some universal features, however, due to cultural relativity, variations occur. To this end, it was established that Ipata market harbours different languages; it also identified calls and spiels with their characteristic stylistic, sociolinguistic and discourse features in the market. In conclusion, the study argued that studying the verbal discourse of marketplaces is significant as it defines what the language-culture-society-relationship is all about.
Performans Denetimi Araştırmalarının Eğilimi: Bibliyometrik ve Görselleştirme Analizi (The Trends of Research on Performance Audit: Bibliometric and Visualization Analysis)
Authors: Yeşilçelebi Gül
Published: September 2022

Bu çalışmanın amacı, performans denetimi üzerine yapılan araştırmaların eğiliminin tespit edilmesidir. Çalışma kapsamında incelenen araştırmalar, Scopus veri tabanından elde edilmiştir. Veri tabanında “performans denetimi” anahtar kelimesi ile arama yapılmıştır. Ayrıca, araştırma kapsamına sadece İşletme, Yönetim ve Muhasebe, İktisat, Ekonometri ve Finans alanında dergilerde İngilizce olarak yayınlanan makaleler dahil edilmiştir. Yapılanarama sonucunda 158 makaleye ulaşılmış ve bu makaleler manuel olarak tek tek incelenmiş, konu ile ilgili olmayanmakaleler yazar tarafından araştırma kapsamı dışında tutulmuştur. Çalışmada, toplam 133makale analiz edilmiştir. Çalışma kapsamındaki makalelerebibliyometrik ve görselleştirme analizi uygulanmıştır. Çalışma sonucuna göre,performans denetimi alanınayayın açısından en çok katkıda bulunan ülke Avustralya’yken;atıf açısından iseİngiltere’dir.Ayrıca yüksek denetim kurumları, finansal denetim, bütçe, finansal kontrol ve muhasebe hilesi gibi konular günümüzde performans denetimi ile bağlantılı olarak tartışılmaya devam etmektedir.Çalışma konusununbibliyometrik analize elverişli olmasına rağmen,literatürde henüz gelişmemiş olduğu tespit edilmiş ve bu açıdan çalışmanın ilgili literatüre katkı sağlaması beklenmektedir.
Covid-19 un Mersin İlinde Faaliyet Gösteren Bir Devlet Hastanesinin Finansal Performansı Üzerine Etkisinin İncelenmesi ( Investigation of the Effect of Covid-19 on The Financial Performance of A State Hospital Operating in Mersin )
Authors: Tutar Melisa , Güngör Tanç Şükran
Published: September 2022

Çalışmanın amacı, 2019-2020 yılları arasında Covid-19 salgın hastalığından hastane finansal performansının ne derecede etkilendiğini ortaya koymaktır. Araştırmanın evreni olan Mersin ilinde faaliyet gösteren bir devlet hastanesinden alınan gelir tablosu vebilançodayer alan verilerden yararlanılarak finansal performans analizi içinde karşılaştırmalı tablolar analizi yöntemi kullanılmıştır.Çalışma sonucunda elde edilen temel bulgulara göre Mersin Devlet Hastanesi’nin dönenvarlıkları, ticari alacakları, stokları, dönem net zararı ve faaliyet zararı 2019 yılına göre 2020 yılında ciddi oranda artış göstermiştir. İlgili hastaneye ait2019-2020 yılları arasındakimali tablohesap kalemlerindegörünen olağandışıfarklılığın sebebininCovid-19 pandemisi olduğusöylenebilir.Çalışmaya istinaden, 2022 yılının ilk çeyreğine kadar etkilerinin yoğun görüldüğü bu salgın,yapılan araştırmaile aslında daha geniş kapsamlı yıllar arasında analiz yapılması gerektiğini ortaya koymuştur.
Clinical Efficacy of Dienogest and Levonorgestrel-Releasing Intrauterine System in the Treatment of Adenomyosis
Authors: Xu Yang , Li Li , Yang Guixia
Published: September 2022

Objective: To compare the clinical efficacy and adverse reactions of dienogest and levonorgestrel-releasing intrauterine system in the treatment of adenomyosis. Methods: A total of 60 cases of adenomyosis admitted to Dezhou Women and Children’s Hospital from January 2020 to October 2021 were selected and randomly divided into two groups (Group A and Group B), which were initiated on dienogest and levonorgestrel-releasing intrauterine system, respectively. The therapeutic effects and adverse reactions of the two groups were analyzed. Results: After 6 months of treatment, the uterine volume in the LNG-IUS group reduced slightly compared with that before treatment, with no statistical significance (p > 0.05), while that in the DNG group increased slightly compared with that before treatment, with no statistical significance (p > 0.05). After 6 months of treatment, the hemoglobin of patients in both groups increased compared with that before treatment; there was no significant difference in the DNG group (p > 0.05), but there was significant difference in the LNG-IUS group (p < 0.01). After 6 months of treatment, the VAS scores of the two groups were significantly lower than those before treatment (p < 0.01); the serum CA125 level in both groups decreased significantly compared with that before treatment (p < 0.01). Conclusion: Mirena (levonorgestrel-releasing intrauterine system) has better therapeutic effect on adenomyosis and fewer adverse reactions than deinogest.
The Level of Expression and Diagnostic Value of Biomarkers in Tuberculous Pleurisy
Authors: Wang Lin , Qi Ying , Qi Suhong
Published: September 2022

Objective: Observe and analyze the clinical significance of the differences in the expression levels of sCD163, haptoglobin and cytokines. Methods: 120 patients with tuberculous pleural effusion diagnosed in our hospital from January 2019 to December 2021 were randomly selected as the experimental group. On the other hand, 40 patients with non-tuberculous pleural effusion admitted in the same period were selected as the control group. The expression levels of sCD163, haptoglobin and cytokines were observed and analyzed. Results: The expression levels of sCD163 (?g/mL), haptoglobin (g/L), IL-6 (pg/mL) and IL-12 (pg/mL) of the control group were 31.26 ± 14.12, 32.14 ± 18.79, 401.23 ± 24.36 and 1.32 ± 0.14, respectively. As for the experimental group, the expression levels of sCD163 (?g/mL), haptoglobin (g/L), IL-6 (pg/mL) and IL-12 (pg/mL) were 74.12 ± 14.78, 113.25 ± 19.45, 612.12 ± 36.98 and 4.12 ± 0.56 respectively, and p < 0.05 which shows that the data was statistically significant. Conclusion: The level of inflammatory cytokines in the pleural fluid of tuberculous pleural effusion patients are higher, which can be used for the diagnosis of auxiliary tuberculous pleurisy. Tuberculous pleural effusion patients has a significantly increased expression levels of sCD163 and haptoglobin in the pleural fluid. The combination of sCD163 and haptoglobin in the diagnosis of tuberculous pleural effusion has higher clinical diagnostic value, and sCD163 and haptoglobin are not interfered by inflammatory factors in the diagnosis of tuberculous pleural effusion
Bibliometric Analysis of Consumer Behaviour Research Conducted During the Covid-19 Pandemic Period
Authors: KARAMAN Davut , SARIKAN Murat
Published: September 2022

In recent years, the Covid-19 pandemic has brought with it changes in consumer behaviour. The purpose of this article is to examine the evolution and trends of consumer behaviour research during the Covid-19 pandemic period. The publications written on the subject of “covid” from the WoS database with the words “consumer behaviour” or “consumer behavior” in their titles were scanned in the business and management category, limiting the years 2020, 2021 and 2022. A total of 642 accessed publications were subjected to bibliometric analysis using the CiteSpace 6 program. The findings show that the number of studies in this field has increased. According to country collaboration analysis, there is a strong country collaboration network between the USA, China, India, Australia, South Korea and the UK. The most studied topic clusters are green consumer behaviour, consumer engagement behaviour and effective service quality. The three most used keywords are impact, consumer behaviour, and model. The study is important as it reveals the trend of consumer behaviour publications during the Covid-19 pandemic period. It is expected that the findings of the study will guide the consumer behaviour researches.
Factors contributing to repository success in recruiting data deposits
Authors: Hayslett Michele , Jansen Matthew
Published: September 2022

What factors make data repositories successful in recruiting research data deposits from scholars? While quite a few studies outline researchers’ data management needs and how repositories can meet those needs, few have assessed the success of various approaches. This study examines infrastructure for accepting data into repositories and identifies factors influential in recruiting data deposits.
Telaah Tematik Esensi Makna ‘Ismah dalam al-Qur’an
Authors: Attamimi Suraya , Aswadi Aswadi , Syafaq Hammis
Published: September 2022

Thematic Study of the Essence of the Meaning of ‘Ismah in the Qur'anThis article discusses the interpretation of the term ‘is}mah in the Qur'an. As a word with conceptual implications, ‘is}mah is often used by Muslim scholars when discussing the incorruptible innocence of the prophets from sins (‘is}mat al-Anbiya>’). This article reviews the meaning of the word along with its scope to see the appropriateness of the theological connotations by collecting all Qur’anic verses that use the word ‘is}mah and its derivations. The twelve verses collected were then arranged chronologically according to the moments of their revelation and analyzed using a thematic interpretation method. The results of this study indicate that ‘is}mah carries two meanings: to prevent or to protect (man‘) and to be steadfast (imsa>k and mula>zamah). Therefore, ‘is}mah has the same meaning as taqwa>, h}ifz}, and isti‘a>dzah. The association of ‘is}mah as a theological concept in the doctrine of prophethood, as commonly discoursed by the mufassirs, is the highest achievement. Meanwhile, the use of this term in the Qur'an shows that ‘is}mah is correlated with three other terms, namely rah}mah, fad}l, and huda>, which focus more on the process of achieving ‘is}mah in the theological context. This article concludes that the ‘is}mah of the prophets is the pinnacle of achievement of the human life process which requires vertical and horizontal faith and piety among human beings.
Kompetensi Pendidik Ideal Berbasis Al-Qur'an (Telaah terhadap Q.S. Luqman; 12, Q.S. Ar-Rahman: 1-5, Q.S. An-Najm: 3-10, Q.S. An-Nahl: 43-44)
Authors: Gunawan Akmal Rizki
Published: September 2022

Al-Qur'an-Based Ideal Educator Competencies (A study of Q.S. Luqman; 12, Q.S. Ar-Rahman: 1-5, Q.S. An-Najm: 3-10, Q.S. An-Nahl: 43-44)The purpose of this study is to analyze theoretical concepts regarding the competence of ideal educators based on the Quran. In this study, the author used the maudhu'i interpretation method, which served to comprehensively explore the thematic ideas of the "ideal educator" in the Qur'an. This paper finds, in Q.S. Lukman; 12 it can be understood that the ideal educator has an argumentative scientific competence that is clean from fallacies, stupidity, so as to change the situation towards the improvement of the aqidah, worship, and morals of the learners. in addition, he also has a gentle and persuasive attitude in conveying messages. In Q.S. Ar-Rahman: 1-5 it can be understood, that the ideal educator is one who is able to teach his students to communicate both orally and in writing. In Q.S. An-Najm: 3-10, it can be understood among the traits that the teacher needs to possess are; a. Physically and mentally strong, (شديدالقوي), b. Intelligent and intellectually high (ذُو مِرَّةٍ), c. Have talents as educators that can be seen from words, behaviors, and deeds (استوى), d. Always establish closeness with students in order to understand and encourage them to move forward ( دنا ), e. Understanding the character as well as the shortcomings of each learner (تدلي), f. Always make efforts to improve in ability as a professional teacher (اْوحى), g. Meet the demands of the curriculum and syllabus (مااْوحى). in Q.S. An-Nahl: 43-44 understandably, the educator must be good at it (Ahl Zikr), in other words his knowledge is broader than the learner. The teacher must also have good handbooks (bayyinat) and diktats (zubur).
Debating Stephen Hawking’s Thought on Creation of Universe: A Qur’anic Scientific Interpretation Perspective
Authors: Adi Deki Ridho , Asnawi Aqdi Rofiq , Hidayaturrohmah Nur
Published: September 2022

Stephen Hawking’s theory “M” posits that the universe was formed without the assistance of God. This paper elaborates the qur’anic position on Hawking’s idea by analyzing the qur’anic scientific interpretation of universe creation. Therefore, the literature review was utilized to collect as much data as feasible, which was then evaluated using the descriptive-analytical method. The findings of this study indicate that Stephen Hawking’s “M” hypothesis has three faults, which constitute a scientific critique of the interpretation of Qur’anic texts relating to the earth and sky. The three faults are: 1) Earth and sky were not created without God’s intervention, as Hawking claimed, but by the will and strength of Allah. This finding is stated in the interpretation of Surah Al-Anbiya’ verse 30, Al-Fushshilat verse 10, and Al-A’raf verse 54. 2) Hawking’s concept of creation is inappropriate since it is based on the rationalism of liberal thought. The natural creation process described in the Qur’an, scientifically proved by science, differs from Hawking’s claim. 3) Hawking’s idea of a mechanism for creating the heavens and the earth is not suitable with the scientific facts regarding them stated in the Qur’an’s scientific interpretation
Faktor–Faktor yang Memengaruhi Niat Pembelian Mi Shirataki Instan: Aplikasi Extended Theory Of Planned Behavior
Authors: Nabila Divayana Frissilia , Nurmalina Rita , Suprehatin Suprehatin
Published: September 2022

Instant shirataki noodles are included in functional foods made from iles-iles tubers (Amorphophallus onchopyllus). Instant shirataki noodles have several benefits because of the glucomannan content in iles-iles tubers. This product experienced a positive increase in demand despite limitations in terms of consumer segment and product availability. This shows that there is a possible purchase motivation by the belief that the product is safe and healthy compared to ordinary instant noodles. The purpose of this study was to analyze the factors that influence the purchase intention of consumers of instant shirataki noodles by expanding the Theory of Planned Behavior. This study used primary data obtained through an online questionnaire. The samples in this study were 450 people. Sample determination using the Purposive sampling method. Data analysis in this study used descriptive analysis and Partial Least Square (PLS-SEM). The results showed that E-TPB model proved to be better in explaining the effect of purchase intention on instant shirataki noodles with variables that had a positive and significant direct effect on intentions, namely attitudes towards behavior, subjective norms, perceived behavioral control, health awareness and perceived availability. In addition, the findings suggest that health awareness and perceived availability can have a significant indirect effect on intentions. The strategy is to create marketing events by inviting consumer reference groups, collaborating with social media influencers, providing customer testimonials, and increasing promotions and product availability.
STRATEGI DIGITAL MARKETING DI MASA PANDEMI COVID- 19: STUDI UMKM DI KOTA METRO
Authors: Andini Dini Gustarina , Bahrudin Moh. , Abdul Ghofur Ruslan
Published: September 2022

Beberapa pelaku UMKM Kuliner di Kota Metro dimasa Covid-19, mengalami penurunan penjualan. Salah satunya Kripik Pisang Tunas. Hal ini menyebabkan pelaku usaha mengalami kerugian yang cukup signifikan. Oleh karena itu, perlu strategi yang tepat dalam mengatasi permasalahan yang terjadi misalnya dengan melakukan strategi penggunaan digital marketing. Penelitian ini menjelaskan efektifitas penggunaan digital marketing dalam meningkatkan penjualan pelaku usaha kuliner, khususnya Kripik Pisang Tunas Metro di masa pandemi Covid-19. Peneliti menggunakan metode penelitian kualitatif dengan pendekatan penelitian lapangan. Sebelum adanya pandemi covid-19 penjualan Kripik Pisang Tunas mengalami peningkatan tetapi tidak signifikan. Setelah adanya pandemi covid-19 dengan merubah pemasaran yang sebelumnya offline menjadi digital marketing maka penjualan mengalami peningkatan secara signifikan karena jangkauan pemasaran yang semakin luas. Hal ini menunjukkan bahwa UMKM yang memanfaatkan digital marketing mampu bertahan di tengah pandemi Covid-19.
Pelaksanaan Pembelajaran Matematika Secara Daring di SMP Negeri 11 Mataram Selama Masa Pandemi Covid-19 Tahun Pelajaran 2021/2022
Authors: Idamayanti Nur , Turmuzi Muhammad , Wahidaturrahmi  , Baidowi
Published: September 2022

This research aims to describe the implementation of mathematics learning online and describe the strategies used by teachers in mathematics learning during the Covid-19 pandemic at SMPN 11 Mataram. This type of research is qualitative research. All students and teachers of mathematics learning at SMPN 11 Mataram are population, where the sample number of 3 mathematics teachers and 76 students are selected by random sampling cluster rules. Data collection uses questionnaires to obtain data on the implementation of mathematics learning online while the interview profit is to explore more in-depth information about teacher strategies in online mathematics learning. From this study, the results were obtained that: (1) The implementation of online mathematics learning in general at SMPN 11 Mataram is in the category quite well. Mathematics learning carried out online is at their respective homes, students use whatsapp, google meet and google forms. (2) Assessment of learning processes and outcomes, evaluation and supervision of the learning process is in the category of good enough where the teacher provides written test analysis and corrects and returns student assignments. Supervision of the online learning process is carried out by teachers by controlling students from the beginning of the lesson to the end of the lesson while parents provide supervision at home by reminding their children to complete assignments from school.
Analisis soal matematika tipe higher order thingking skill (hots) kelas vii mts pondok pesantren khairul fatihin nw ijobalit
Authors: Asri Febian , Baidowi  , Novitasari Dwi , Turmuzi Muhammad
Published: September 2022

This study aims to describe the quality of the analysis of Class VII mathematics problems of MTs Khairul Fatihin NW Ijobalit academic year 2020/2021 HOTS type viewed from the aspects of validity, reliability, difficulty level, differentiator and finisher. The type of research used is quantitative descriptip. Subjects in this study were students of Class VII MTs Pondok Pesantren Khairul Fatihin NW Ijobalit which amounted to 37 people. The object of the study was hots type math problems and the answers of grade VII students of the even Semester of the 2020/2021 school year, which consisted of 35 objective questions. Data collection techniques are carried out by interview and documentation methods. The results showed that: there are 4 questions category HOTS where all the questions cognitive level is C4 in terms of validity, item hots problem classified as a valid problem; in terms of reliability, hots problem classified as a matter of moderate reliability with an index of 0.469; in terms of differentiating power, the item about HOTS is in the category enough with a percentage of 75%; in terms of difficulty level, the item about hots classified as having a moderate difficulty level; in terms of the effectiveness of the Spieler, hots problem has a very good Spieler effectiveness because the Spieler is selected with a percentage of more than 5%.
KEANEKARAGAMAN JENIS PLANKTON DI PERAIRAN BATU BELUBANG DAN PULAU PANJANG KABUPATEN BANGKA TENGAH SEBAGAI INDIKATOR KUALITAS PERAIRAN
Authors: Novrilianty Herlena , Hudatwi Mu’alimah , Utami Eva
Published: September 2022

Plankton adalah organisme mikroskopis yang memiliki peranan yang sangat penting yaitu sebagai dasar dari kehidupan, khususnya dalam kehidupan perairan pelagis. Plankton digolongkan menjadi dua jenis yaitu : fitoplankton dan zooplankton. Penelitian ini bertujuan untuk mengetahui jenis plankton, mengidentifikasi hubungan keanekaragaman jenis plankton dengan parameter fisika dengan analisis statistik, dan mengidentifikasi indeks keanekaragaman jenis plankton di Perairan Pantai Batu Belubang dan Pulau Panjang. Waktu dan tempat penelitian ini dilaksanakan pada bulan Bulan Maret 2021 di Perairan Pantai Batu Belubang dan Pulau Panjang Kecamatan Pangkalan Baru Kabupaten Bangka Tengah. Pengambilan data dalam Penelitian ini menggunakan metode random sampling dimana berdasarkan hasil survei yang telah dilakukan. Hasil penelitian menunjukkan bahwa di perairan Pantai Batu Belubang dan Pulau Panjang ditemukan 30 spesies plankton yang terdiri dari 13 family dan total  berjumlah 286 spesies dengan indeks keanekaragaman tergolong sedang, indeks keseragaman tergolong tinggi dan untuk indeks dominansi tergolong rendah. Hasil korelasi menunjukkan bahwa memiliki hubungan korelasi yang berbeda-beda nilai dan arahnya.