bluuebunny/crossref_metadata_2025 huggingface dataset:
Massive Fibroepithelial Polyp of the Oral Mucosa: A Rare Case Report
Authors: Jihed Sghaier , Smida Abdelkader , Slim Afef , Garma Maroua , Abdellatif Chokri , Selmi Jamil
Published: October 2023

Fibroepithelial polyps (FEPs) are common benign tumors in the mouth. They normally develop gradually in certain locations and are caused by local irritation or trauma. Their dimensions usually do not exceed 5 millimeters. We report a rare case of a giant fibroepithelial polyp in a 46-year-old man on the internal surface of the cheek. He was referred to our Oral Medicine and Oral Surgery Department on account of a massive lesion on the right buccal mucosa. This patient underwent an excisional biopsy under local anesthesia. Histological examination confirmed the diagnosis of fibroepithelial polyp. Fibroepithelial polyps are a very common occurrence. But lesions reaching a huge size are extremely rare. Physicians should properly diagnose and manage these lesions effectively to prevent recurrences and malignant transformation.
The Incidence and Location of Different Types of Ring Enhancing Lesion of Brain
Authors: Akhter Sumona , Md. Akhtaruzzaman Md. Akhtaruzzaman , Hossain A.K.M. Anowar , Alam Md. Mashkurul , Ferdaushi Umme Habiba , Islam Md. Nazrul , Ahsan Md. Mainul
Published: October 2023

Background: Ring-enhancing lesions are one of the most common types of neuroimaging abnormalities. Many different primary and secondary brain tumors, including glioblastomas, low-grade gliomas, and brain metastases, can also manifest as ring-enhancing lesions. Aim of the study: The objective of this study is to assess the incidence and location of different types of ring enhancing lesion of brain. Methods: This prospective observational study was carried out from January 2012 to December 2013 at the Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, Department of Radiology and Imaging, in collaboration with the Department of Neurosurgery. 56 cases total were randomly chosen for the study population based on clinical and brain CT results. First, all the pertinent information was gathered on a master chart, after which it was arranged using a scientific calculator and the proper statistical formulas. Finally, using MS Office and SPSS programs as necessary, all data were processed, examined, and disseminated. Results: The present study was found that among the ring enhancing lesions of brain patients, highest percentage were in the range of 31-40 years (35.7%). Clinical features of different etiologies headache emerged as the most common complaint that the patients presented. Out of 56 patients, 45 (80.4%) complained of headache. Parietal was observed as the most common site of lesion of 31 (57.1%). Parenthesis indicates percentage out of 21 diagnosed Glioma patients, 20 (95.2%) were single number of lesion and the rest 1 (4.8%) was multiple number of lesion. Perilesional Parenchymal changes were observed 45 (80.3%) patients. Conclusion: The present study was designed and attempted to find out the incidence and location of different types of ring enhancing lesion of brain. This was a single centre study and may limit the ability to reflect the generalized population in our country.
Analysis of the Constraints Influencing Artisanal Fisheries along Shiroro and Kainji Dams, Nigeria
Authors: J Alhassan Y. , S Umar , A Gona , S Jega I.
Published: October 2023

This study analyzed the constraints influencing artisanal fisheries along Shiroro and Kainji dams, Nigeria. Questionnaire was used to collect data from 460 respondents. Multi-stage and proportionate sampling techniques were used in selecting the respondents. Descriptive statistical tools (frequency distribution, percentages, mean and ranking) were used for data analysis. The results of the study showed that majority of the respondents were male (82.2%) and were within the age (51.3%) bracket of 29-41years, indicating that respondents were middle aged fishers who fall within the active fishing age. Majority (87.0%) of the fishers were married with an average household size of 6 persons. The study found out that the constraints faced by the fishers to include high cost of fishing gear (72.8%) which is the most serious constraint, closely followed by lack of credit facilities (50.7%) and lack of modern equipment (50.2%). The findings on interventions received by the fisher’s shows that majority of the respondents (44.4%) received fishing gears, closely followed by improved market structures (37.6%) and provision of roads linking villages (37.2%). Findings on the strategies towards the development of artisanal fisheries reveal that (70.9%) fishers ranked 1st supported enhanced extension service delivery, (67.8%) respondents’ ranked 2nd suggested provision of credit facility and (55.4%) respondent’s ranked 3rd supported provision of processing facilities. Conclusively, the research showed that, fishing activity is an important livelihood activity in the lives of the fishers along the two dams. The constraints that faced the industry such as high cost of fishing gears, lack of credit facilities etc hindered full realization of the potentials of the industry. The study therefore, recommended that financial institutions should grant credit facilities to fishers and their educational level should be improved.
Antimicrobial and Phytochemical Activities of Garlic (Allium sativum) on Staphylococcus aureus and Candida albicans Isolated from High Vaginal Swab samples and Female Students with UTI
Authors: Jaluchimike Iloputaife Emmanuel , Jacinta Aneke Chinwe , Ngozi Ewoh Anthonia
Published: October 2023

Studies on antimicrobial and phytochemical activities of garlic on Staphylococcus aureus and Candida albicans isolated from HVS samples and female students with urinary tract infection were investigated. Garlic is used in many homes as condiment or as flavoring agent. The garlic used was purchased from Eke market Agbani in Nkanu West Enugu State Nigeria. Ten Urine and HVS samples were collected from female students using a universal container and swab sticks. Preliminary qualitative phytochemical analysis was done using standard methods. The powder of garlic was macerated in ethanol and chloroform to produce crude extract reconstituted with distilled water to concentrations of 200mg/ml, 100mg/ml, 50mg/ml, 25mg/ml and 12.5mg/ml. The ethanol and chloroform extract of garlic obtained was used to evaluate antimicrobial activity against Staphylococcus aureus and Candida albicans. Also, minimum inhibitory concentration was determined. The garlic extract contained alkaloids, tannins, flavonoids, terpenoids and saponins. The inhibitory effect of ethanol extract started at 200mg/ml with inhibition zones of 2mm against Staphylococcus aureus and Candida albicans. MIC result for garlic extract on Staphylococcus aureus and Candida albicans showed that the extract has inhibitory effect at low concentration of 50mg/ml and inhibition increased at 100mg/ml. Ethanol extract was the most effective extract retarding microbial growth of Staphylococcus aureus and Candida albicans. This study however, justify the use of garlic extract in traditional medicine practice as a therapeutic agent. In cases where possible, the ethanol extracts of garlic should be used at a concentration up to 100mg/ml so as to give a better treatment.
Fetal Oropharyngeal Teratoma: A Rare Tumour: A Case Report
Authors: Lata Gagan , Singla Liza , Walia Moneet
Published: October 2023

Teratomas generally constitute 25-30% of congenital tumours with oropharyngeal tumours being very rare. The tumor typically arises from the palato-pharyngeal region around the basishenoid. Incidence is in 1 in 35,000-200,000 of live births. Most head and neck teratomas are incidental findings on routine second-trimester ultrasonography and are usually associated with polyhydramnios in 40% of cases. This case was also diagnosed with fetal oropharyngeal tumour at 20 weeks USG and was associated with polyhydramnios. After counselling, couple opted for termination of pregnancy in view of poor prognosis. After expulsion, products of conception were sent for histopathology and karyotyping.
The Hidden Economic Consequences of Migraine to the UK Government: Burden-of-Disease Analysis Using a Fiscal Framework
Authors: Martins Rui , Large Samuel , Russell Rachel , Surmay Gary , Connolly Mark P.
Published: October 2023

Background: Migraine is a highly prevalent and incapacitating neurological disorder associated with the highest global disability burden in people aged 15 to 49 years. Europe has the fourth-highest prevalence of migraine, after North America, South America, and Central America, and above Asia and Africa. Migraine leads to relatively modest direct healthcare expenditure but has substantial indirect costs due to reduced productivity.

Methods: The economic burden of migraine was estimated in comparison with the general population of the United Kingdom (UK) using an analytical fiscal modeling framework applying the government cost perspective. Published measures of migraine’s impact on labor participation were applied to rates of economic activity/inactivity of the general population. The model estimates lifetime changes to earnings from employment, direct and indirect taxes paid, and financial support requirements over the life course. Incremental differences between those affected and unaffected by migraine are reported as net fiscal consequences to public accounts. Fiscal costs are reported as the discounted average per capita over a 20-year time horizon and for the entire annual UK cohort with prevalent migraine.

Results: People affected by migraine are more likely to be absent from work, unemployed, and disabled, and to retire early. A 44-year-old individual affected by migraine was associated with £19 823 in excess fiscal costs to the UK government, £1379 per year living with the condition, compared with someone not affected by the disease. Annually, migraine was estimated to represent £12.20 billion to the public economy, approximately £130.63 per migraine episode. The model predicted annual productivity losses in the health and social care workforce to be £2.05 billion and total annual productivity losses to be over £5.81 billion.

Conclusions: This fiscal analysis monetizes the occupational consequences of migraine to the UK government, both in terms of lost tax revenue and transfer payments. The findings are substantial and useful to characterize disease severity and to inform the body of evidence considered by decision makers appraising the cost-effectiveness of health technologies.
The Effect of Independence, Due Professional Care, and Experience on Audit Quality
Authors: Bayu Bayu , Budiantoro Harry , Lapae Kanaya , Supriyatin Supriyatin , T S Hesty Juni
Published: October 2023

In order to determine how independence, appropriate professional care, and experience affect audit quality at the Public Accounting Firm (KAP) in North Jakarta, this study will look at these factors. The respondents in this study were auditors from the North Jakarta Public Accounting Firm (KAP). In this study, 50 respondents representing 6 Public Accounting Firms (KAP) in North Jakarta served as the sample of auditors. Convenience sampling, or selecting the sample that can be found the easiest, was used to select the sample for this study. While researchers use multiple regression analysis as a data processing technique. According to the study's findings, independence, due professional care, and experience all significantly and favorably affect audit quality.
The Importance of Information Technology Project Management Management Towards the Success of a Company
Authors: Sugara Dymas Kharafi , Murti Galuh Tresna , Sitanggang Shendy Tiodor Lina , Saputri Yolla Eka
Published: October 2023

The presentation of the results in the worksheet of this paper explains the extent to which information technology project management is important to the company. The method used in its preparation is descriptive qualitative method. This method is carried out by examining and determining validity and analyzing from various perspectives. The preparation of this paper worksheet uses a variety of different data sources. The results found indicate that the importance of managing an information technology project will affect the success or failure of a company. information
The Influence of the Audit Committee and Corporate Social Responsibility Disclosure on Earnings Management
Authors: Ratiningsih Aprilia Pasca , Nugrahanti Yeterina Widi
Published: October 2023

This study aims to see the effect of Audit and Disclosure of Corporate Social Responsibility (CSR) on Earnings Management. The population in this study are manufacturing companies listed on the Indonesia Stock Exchange (IDX) in 2019-2021. The total population in this study is 128 companies listed on the Indonesia Stock Exchange (IDX). The sample taken is a company engaged in the manufacturing sector on the Indonesia Stock Exchange (IDX) which was selected using a purposive sampling method. The analytical method used in this research is quantitative analysis. The results of the study simultaneously show that the Frequency of Audit Committee Meetings and Disclosure of Corporate Social Responsibility (CSR) have a negative influence on Earnings Management.
Understanding How Investigative Auditors' Competence, Independence, and Experience Affect the Efficiency with Which Audit Procedures are Implemented in Fraud Proof
Authors: Pramesti Dyah Sisca Putri , Koeswayo Poppy Sofia , Devano Sony
Published: October 2023

Fraud is increasingly widespread in Indonesia. In detecting and proving fraud, a special audit is needed, namely an investigative audit. Auditors who carry out investigative audits are called investigative auditors. This study aims to determine the effect of investigative auditor competence on the effectiveness of audit procedures in proving fraud, the effect of investigative auditor independence on the effectiveness of audit procedures in proving fraud, the effect of investigative auditor experience on the effectiveness of audit procedures in proving fraud, the effect of auditor experience on auditor competence. , and the influence of investigative auditor competence on the effectiveness of the implementation of audit procedures in proving fraud through auditor experience. This study uses a quantitative research method using primary data obtained from the results of questionnaires distributed to investigative auditors at the Supreme Audit Agency (BPK RI). The population in this study is the Main Investigation Auditorate at the Supreme Audit Agency of the Republic of Indonesia. The sample used is the Main Investigation Auditorate at BPK RI. The data analysis technique used is path analysis with a significance level of 5% using SPSS 26 software. The results of this study are that the competence of investigative auditors has a positive effect on the effectiveness of implementing audit procedures in proving fraud, the independence of investigative auditors has a positive effect on the effectiveness of implementing audit procedures in proving fraud, the experience of investigative auditors has a positive effect on the effectiveness of implementing audit procedures in proving fraud, there is a positive effect of auditor experience on auditor competence, and the experience of investigative auditors has a positive effect on the effectiveness of implementing audit procedures in proving fraud through auditor competence.
Abordagens Atuais no Tratamento da Diabetes Tipo 2: Uma revisão das terapias farmacológicas e não farmacológicas mais recentes para o controle da DM2.
Authors: Souza Luiza Lima Pinto de , Higa Karina Carvalho , Costa Igor Martins , Barreto Ana Júlia Nassar , Matos Isadora Monteiro
Published: October 2023

Este artigo de revisão aborda as abordagens atuais no tratamento da diabetes tipo 2 (DM2), uma condição metabólica crônica que representa um desafio significativo para a saúde global. O objetivo é analisar a eficácia das terapias farmacológicas e não farmacológicas mais recentes no controle da DM2, considerando tanto o controle glicêmico quanto os desfechos cardiovasculares. No que diz respeito às terapias farmacológicas, a metformina permanece como uma escolha eficaz como terapia inicial, devido à sua capacidade comprovada de reduzir os níveis de hemoglobina A1c (HbA1c). No entanto, terapias farmacológicas subsequentes devem ser escolhidas com base nas características individuais do paciente. Inibidores do cotransportador de sódio-glicose 2 (SGLT2) e agonistas do receptor de peptídeo semelhante ao glucagon 1 (GLP-1) emergiram como opções versáteis que não apenas reduzem HbA1c, mas também melhora os desfechos cardiovasculares. Por outro lado, as terapias não farmacológicas, como dieta e exercício, continuam sendo pilares fundamentais no manejo da DM2. Dietas saudáveis, como a mediterrânea, têm demonstrado benefícios na redução de HbA1c e na promoção da saúde cardiovascular. O exercício regular melhora a sensibilidade à insulina e contribui para a perda de peso. Além disso, a cirurgia bariátrica é uma opção eficaz em casos selecionados, mas requer avaliação cuidadosa devido aos riscos envolvidos. Em resumo, a gestão da DM2 exige uma abordagem integrada que leve em consideração as terapias farmacológicas e não farmacológicas disponíveis, bem como as características individuais do paciente. A compreensão dessas opções terapêuticas é crucial para alcançar o controle glicêmico adequado e melhorar a qualidade de vida dos pacientes com DM2.
Abordagens Multidisciplinares para o Tratamento da Dor Crônica: Uma revisão das terapias integrativas e estratégias de manejo da dor crônica, incluindo medicamentos, fisioterapia e terapias alternativas.
Authors: Mendonça Juliana Coimbra de , Martins Verônica de Souza , Rodrigues Mario Paulo Damis , Fernandes Caio Henrique Freitas , Fernandes Ingrid Freitas
Published: October 2023

A dor crônica é uma condição debilitante que afeta milhões de pessoas em todo o mundo, tendo um impacto significativo na qualidade de vida. Este artigo de revisão explora abordagens multidisciplinares para o tratamento da dor crônica, abrangendo terapias integrativas e estratégias de manejo que incluem medicamentos, fisioterapia e terapias alternativas. A medicina desempenha um papel importante no alívio da dor crônica, mas não deve ser a única consideração. Medicamentos podem trazer alívio imediato, mas podem vir acompanhados de efeitos colaterais e riscos. Portanto, a personalização do tratamento é essencial, levando em consideração a causa da dor e as preferências do paciente. A fisioterapia destaca-se como uma abordagem eficaz, melhorando a função física e a qualidade de vida. Exercícios terapêuticos, alongamento e mobilização articular têm um impacto positivo em uma variedade de condições, com a participação ativa do paciente desempenhando um papel crucial no sucesso do tratamento. Terapias alternativas, como acupuntura, quiropraxia e meditação, oferecem benefícios significativos para muitos pacientes. Embora sua eficácia varie, é importante que os pacientes tenham a oportunidade de explorar terapias que se alinhem às suas preferências. A pesquisa futura deve abordar questões metodológicas e se concentrar em abordagens personalizadas. Com uma compreensão mais profunda dos mecanismos da dor e terapias mais direcionadas, é possível melhorar o manejo dessa condição desafiadora, promovendo o bem-estar e a funcionalidade dos pacientes.
Complicações Pós-Operatórias em Cirurgia Abdominal: Uma revisão das complicações mais comuns após cirurgias abdominais, como infecções, hérnias incisionais e obstruções intestinais
Authors: Silva Laion Roberto Ferreira da , Santos Luiza Penido de Freitas , Amaral Lucas Oliveira , Beirigo Thayná Pereira , Menezes Lucca Batista Rocha De
Published: October 2023

Este artigo de revisão aborda complicações pós-operatórias em cirurgia abdominal, com foco nas infecções, hérnias incisionais e obstruções intestinais. Essas complicações representam desafios significativos que afetam a recuperação e a qualidade de vida dos pacientes. As infecções pós-operatórias, variando de infecções superficiais a peritonite, são uma preocupação comum, aumentando custos médicos e riscos à saúde. A profilaxia antimicrobiana baseada em diretrizes é eficaz na prevenção, mas a resistência bacteriana e a pesquisa contínua são áreas críticas. Hérnias incisionais são complicações crônicas que afetam a qualidade de vida dos pacientes. Estratégias de prevenção incluem técnicas cirúrgicas aprimoradas e uso de biomateriais. A vigilância a longo prazo é crucial para detectar recorrências precocemente. Obstruções intestinais, potencialmente fatais, requerem diagnóstico e tratamento rápidos. A colaboração entre especialistas é vital para avaliação e planejamento de tratamento. Abordagens minimamente invasivas e terapias farmacológicas estão em desenvolvimento. A prevenção, detecção precoce e tratamento adequado são fundamentais. Uma abordagem multidisciplinar e coordenação de cuidados são essenciais. Este artigo destaca a importância de aprimorar a compreensão e a gestão dessas complicações complexas, visando a otimização dos resultados cirúrgicos e a melhoria da qualidade de vida dos pacientes após cirurgias abdominais.
Etiology of placental insufficiency in women in the second trimester of gestation during the epidemic of influenza A(H3N2) and pandemic influenza(H1N1)pdm
Authors: Gorikov I. N. , Reznik V. I. , Sergievich A. A. , Nakhamchen L. G. , Odireev A. N. , Prokopenko A. V. , Таrasyuk E. S. , Sudakov A. G. , Коlomiets O. E. , Gaidarova A. V.
Published: October 2023

Aim. To study the etiology of placental insufficiency in women in the second trimester of gestation during the influenza A(H3N2) epidemic and the A(H1N1)pdm pandemic.

Materials and methods. In 1865 patients in the second trimester of pregnancy, uncomplicated and complicated by exacerbation of chronic ENT pathology leading to the development of placental insufficiency, using laboratory methods in the blood, nasal epithelium and biological fluids, pathogens of monoand mixed infections (influenza A(H1N1)pdm), A(H3N2), influenza B, parainfluenza type 1-3, adenovirus, respiratory syncytial virus (RS), cytomegalovirus (CMV), herpes simplex virus type 1 and type 2 (HSV-1,2 type), candida infection (Candida albicans), chlamydia (Chlamydia trachomatis), mycoplasmosis (Mycoplasma hominis) and ureaplasmosis (Ureaplasma urealyticum) were detected. The first group consisted of 873 women with placental insufficiency diagnosed during the influenza A(H3N2) epidemic, the second group consisted of 890 patients with placental insufficiency diagnosed during circulation of the influenza A(H1N1)pdm in the population. The control group were 42 women without ENT diseases and placental insufficiency caused by monoand mixed viral infections during influenza A(H3N2) and 60 women with similar somatic, infectious and obstetric status, examined during pandemic influenza A(H1N1)pdm.

Results. With the development of placental insufficiency in women of the second group, compared with the first one, mono-influenza B and parainfluenza types 1-3 are diagnosed less frequently, as well as a combination of influenza A(H1N1) pdm and influenza B; influenza A(H1N1)pdm and parainfluenza types 1-3; influenza A(H1N1)pdm and RS virus; CMV and Chlamydia trachomatis; Mycoplasma hominis and Ureaplasma urealyticum; HSV-1,2 type, Candida albicans and Chlamydia trachomatis; as well as HSV-1,2 type, Candida albicans and Ureaplasma urealyticum. At the same time, exacerbations of mono-CMV, mono-HSV-1,2 type and Candida albicans are more common, as well as combinations of CMV+HSV-1,2 type; CMV+Candida albicans; CMV+Ureaplasma urealyticum; and CMV+Mycoplasma hominis; CMV+HSV-1,2 type+Candida albicans.

Conclusion. In the etiology of placental insufficiency in acute diseases of the ENT organs in women in the second trimester of gestation against the background of circulation of the A(H1N1)pdm influenza in the population, compared with placental dysfunction in pregnant women with a similar ENT pathology during the influenza A(H3N2) epidemic, there is an increase in the proportion of monocytomegalovirus, herpesvirus and candida infections, as well as mixed cytomegalovirus infection, the reactivation of which may be due to more pronounced virusinduced immunosuppression and hormonal status disorders, leading to local dysbiosis.
Clinical observation of small cell neuroendocrine cancer of the tracheal bifurcation zone, with metastasis to the bone marrow, liver, spleen
Authors: Voitsekhovskiy V. V. , Grigorenko A. A. , Esenina T. V. , Roshchin S. N. , Filatova E. A. , Fedorova N. A. , Astasheva T. A. , Solovieva M. I. , Tuboltseva N. V.
Published: October 2023

Aim. Demonstration of a clinical case of a patient with small cell neuroendocrine cancer of the tracheal bifurcation zone, with metastases to the bone marrow, liver, spleen.

Materials and methods. A brief review of the literature on the diagnosis of neuroendocrine tumors of the lungs and bronchi is presented, and a clinical observation of small cell neuroendocrine cancer of the tracheal bifurcation zone with metastases to the bone marrow, liver and spleen from the personal practice of the authors is presented.

Results. The clinical picture of this patient was dominated by “hematological” manifestations: severe thrombocytopenia and hemorrhagic syndrome, anemia, due to which differential diagnosis with a systemic blood disease was initially carried out. There was no pain syndrome in the bones characteristic of metastatic lesions. Histological examination of the bronchial tumor biopsy and bone marrow trephine biopsy with immunohistochemical examination (IHC) helped in making the diagnosis. In both cases, IHC revealed tumor cells with the same phenotype.

Conclusion. Metastasis of tumors to the bone marrow can proceed without characteristic ossalgia and manifest itself only in hematological syndromes (changes in blood tests). Cytological and histological examination of the bone marrow, with IHC, helps in the diagnosis.
Contact methods for registering respiratory rate: opportunities and perspectives
Authors: Garanin A. A. , Rubanenko A. O. , Shipunov I. D. , Rogova V. S.
Published: October 2023

Introduction. Respiratory rate is known to be one of the most important indicators reflecting the vital functions of a person. An increase in respiratory rate can be found in many diseases and pathological conditions, for example, in chronic obstructive pulmonary disease, pneumonia, bronchial asthma, myocardial infarction, heart failure, anaemia, etc. Due to the active introduction of telemedicine monitoring into clinical practice, the measurement of the abovementioned indicator is particularly relevant for the purpose of early detection and prevention of complications of chronic non-infectious diseases, as well as dynamic monitoring of the condition of patients in both inpatient and outpatient settings.

Aim. To search and update information about existing and promising developments for the control of respiratory rate based on different physical principles.

Materials and methods. For this review we used databases PubMed, Scopus, MedLine and eLIBRARY. The following keywords were used for the search: “respiratory rate”, “contact”, “measurement”, “sensor”.

Results. Contact methods for measuring respiratory rate include a wide range of sensors based on various physical principles. All types of sensors have their own application, but also they have some drawbacks. In order to achieve maximum accuracy of respiratory rate monitoring, it is necessary to carefully assess the conditions in which the patient is located, selecting the most appropriate technological solutions for them. Probably, complex systems, including several different sensors, are able to overcome many shortcomings. In addition, the development of information analysis methods, machine learning and artificial intelligence technologies can increase the sensitivity and accuracy of methods of measuring respiratory rate, reducing the frequency of bias associated with various artefacts.

Conclusion. Thus, technological development opens up wide opportunities for long-term monitoring of vital functions, prevention and timely response to adverse events.
The state of mitochondrial membrane potential in peripheral blood leukocytes of patients with chronic obstructive pulmonary disease
Authors: Sugaylo I. Yu. , Gassan D. A. , Naumov D. E. , Kotova O. O. , Gorchakova Y. G. , Sheludko E. G.
Published: October 2023

Introduction. Mitochondria provide energy homeostasis of the cell by maintaining an optimal transmembrane electrochemical gradient (ΔΨm), which does not allow excessive formation of reactive oxygen species (ROS). However, under conditions of pathology, the normal functioning of mitochondria is disrupted, which can lead to ATP deficiency and/or increased production of ROS.

Aim. The aim of this study was to investigate the ΔΨm parameters and their relationship with the expression of TRP channels in peripheral blood leukocytes of patients with chronic obstructive pulmonary disease (COPD).

Materials and methods. The study included 23 patients with COPD of varying severity, 8 smokers without signs of bronchial obstruction and 9 healthy volunteers who had never smoked. All subjects underwent spirometry to assess the lung function. ΔΨm was determined by staining the cells with tetramethylrhodamine ethyl ester (TMRE) and measuring the fluorescent signal by flow cytometry, under basal conditions and pro-inflammatory stimulation with phorbol-12-myristate-13-acetate (PMA).

Results. We found that COPD patients were characterized by a significant increase in basal ΔΨm of monocytes (161.8 [153.8; 206.8] vs. 129.3 [75.5; 161.8], p=0.03) and lymphocytes (209,7 [184.7; 257.8] vs. 122.5 [67.9; 164.3], p=0.003) as compared with the control group. Stimulation of cells with PMA led to multidirectional changes in ΔΨm, while its increased level was still preserved in COPD. In monocytes of COPD patients, a decrease in ΔΨm in response to PMA stimulation was prevalent (75%), while in the majority (53.9%) of individuals in the control group ΔΨm, on the contrary, increased (p=0.08). In addition, among COPD patients, an increase in ΔΨm in monocytes was accompanied by an enhanced expression of TRPV4, while in the control group, among individuals with positive dynamics of ΔΨm, TRPV4 expression was, on the contrary, reduced.

Conclusion. The increased level of ΔΨm in the mononuclears of COPD patients is consistent with previously detected enhanced ROS production, but does not support the assumption about energy deficit in the cells. The revealed differences in the relationship between TRPV4 expression and ΔΨm dynamics may indicate the presence of pathological features in TRP signaling in COPD patients.
Bronchopulmonary dysplasia in children of the Amur region: the structure of the disease
Authors: Suprun S. V. , Abdulina N. O. , Pichugina S. V. , Sorvina T. A. , Evseeva G. P. , Lebedko O. A.
Published: October 2023

Aim. Analysis of the structure of bronchopulmonary dysplasia (BPD) in children of the Amur region at the stage of medical care in outpatient and inpatient conditions of the Research Institute of MCP for the period from 20102021.

Materials and methods. The study used a retrospective analysis of outpatient records and medical histories of 146 patients with BPD aged from 1 month to 13 years.

Results. Among children with BPD, boys accounted for 56.6%, girls 44.3%. Preterm infants accounted for 84.9%, full-term babies – 15.1%. The classic form of the disease was diagnosed in 56% of children, the new form – in 44%. Since 2013, there has been a decrease in the frequency of occurrence of the classical form (in 2011 – 100%, in 2021 – 0%). The opposite pattern is typical for the new form (in 2010 – 14.3%, in 2021 − 100%). Since 2018, there has been a tendency for the new form to prevail over the classical form. Concomitant pathology of the respiratory system was diagnosed in 40.2% of patients (5.03% of them were malformations, stridor – 33.3%, their combination – 1.9%), and pathology of the cardiovascular system in 3.8% of cases.

Conclusion. The assessment and dynamics of the structure of BPD disease in the Amur region at the present stage is presented. We report the predominance of a new form of BPD over the classical one. The study noted the frequency of concomitant pathology on the part of the respiratory and circulatory systems in children with BPD. The identified features will be used to search for risk factors for the development and prognosis of this pathology.
Functional modeling of a system for monitoring technological processes based on the concept of digital twin
Authors:   Antonov S.V.
Published: October 2023

The results of modeling a system for monitoring technological processes based on the concept of a digital twin for working in small-scale multi-product digital industries are presented. A feature of this model is that it includes algorithms and methods for comparative analysis of the values of process parameters in real time.

Keywords
technological process monitoring, digital manufacturing, digital twin, smart manufacturing, information system, functional modeling
Development of an algorithm for refineding parameters vehicle suspensions
Authors:   Dyakov I.F. Moiseev YU.V.
Published: October 2023

The research results of the oscillations for sprung and unsprung masses in the frequency range are presented. The amplitude-phase frequency characteristics of individual masses during vibrations with follow-up presentation of transient processes, and the main results on the refinement of vehicle suspension parameters are determined. The function of the damping time of vehicle oscillations is considered. The time function a program algorithm that can be used when designing a vehicle to find the minimum value is developed. The purpose of the work is to rice the comfort of the vehicle by minimizing the damping time of the sprung mass oscillations.

Keywords
oscillation frequency, suspension system, static and dynamic suspension deflection, oscillation damping time, suspension parameters refinement algorithm
Use of multistage gamma correction at magnetoresonance investigations
Authors:   Safarova S.D. Ragimov A.T.
Published: October 2023

The article is devoted to the issues of contrasting images obtained during magnetic resonance (MR) studies. The conducted studies have shown that the nuclear-magnetic and other physical processes occurring in the tomograph do not allow the contrast to be adjusted within the necessary limits. A television method for adjusting contrast — gamma correction, which allows researchers to more accurately diagnose diseases — is proposed.

Keywords
contrast, gamma correction, magnetic resonance diagnostics
Optimization of information flows and development of a predictive model for organizing the information space in digital energy
Authors:   Sahanskiy YU.V. Gagloeva I.E. Soin A.M.
Published: October 2023

The application of modern information technologies in the electric power industry of the national economy of Russia is considered. The main digital technologies with the maximum potential for use in the electric power industry are given. The stages of the digital flows organization are determined for the development of a model for organizing the information space in the digital energy. The main indicators of the digitalization introduction in the energy sector, as well as factors hindering the process of digitalization of the electric power industry in Russia, are determined. A model for organizing the information space in the digital energy sector of Russia for the medium and long term is developed.

Keywords
energy, digitalization, data optimization, information flow, big data, artificial intelligence, renewable energy sources
Algorithms for program control of technological parts manufacturing process
Authors:   Dyakov I.F. Moiseev YU.V. Dyakov V.I.
Published: October 2023

Algorithms for program control of the technological process of manufacturing parts used in mechanical engineering are proposed. The software is based on a functional subsystem corresponding to optimization methods. The technological process is presented in the form of algorithms, blocks, tasks and settings. Technological procedures for the manufacture of machine parts are analyzed. The parameters for setting the control cyclograms are shown, which are aimed at creating unified software and means of operational adjustment for specific tasks in the manufacture of machine parts, which ensure the accuracy of processing with minimal time costs.

Keywords
unified algorithm, technological procedure, optimization, mathematical model, operation, setting parameter, specification level
Small power generation based on piezoelectric generators
Authors:   Ismagilov F.R. Vavilov V.E. YAngirov I.F. Halikov A.R
Published: October 2023

A new type of small-scale power generation based on piezoelectric generators is considered. Designs of devices in which piezoelectric generators are used are proposed. Their efficiency and possible fields of application are shown.

Keywords
piezoelectric generator, voltage, force impact, current, small power generation, autonomous power supply
Application of UAV in surveying objects of high-voltage line and power transmission lines and removing damages
Authors:   Solovev M.O.
Published: October 2023

The use of unmanned aerial vehicles (UAV) in the inspection of power transmission lines (TL) objects and elimination of damages is considered. The problem urgency of the operational search for damages with their subsequent elimination at high-voltage lines (HVL) and power transmission lines is substantiated. The factors leading to the disruption of the equipment and facilities of power transmission lines objects are determined. It was revealed that in modern conditions the use of UAV allows not only monitoring the objects of HVL and power transmission lines, but also certain types of work. The experience of using UAVs for searching and analyzing damage of HVL and power transmission line objects in Russia and other countries is considered. It is concluded that the advantages of using UAVs in the energy sector include UAV maneuverability, solving issues of mapping and aerial photography, modern technical support for the safety of power grids, the ability to receive information in a short time and in real time, automation of certain types of work, reducing the number of field trips, reducing scope of work in the high voltage zone and at high altitudes, which reduces the risks associated with the human factor.

Keywords
unmanned aerial vehicle (UAV), high-voltage line (VL), power transmission line (PTL), thermal imaging survey, aerial monitoring, operation of facilities and equipment
Technical means for storage systems state monitoring of the cryogenic products during transportation by air transport
Authors:   Soldatov E.S. Soldatov A.S.
Published: October 2023

The article is devoted to the use of technical means for monitoring of the storage systems state filled with a cryogenic product during air transportation. The necessity of providing autonomous power supply to the elements of the monitoring system mounted directly on the structure of the storage system is substantiated. A diagram of a monitoring system for real-time tracking of the condition of tank containers transported by air and connected to the monitoring system via a satellite communication network is given.

Keywords
cryogenic tank-container; cryoproduct; multimodal transportation; air transportation; satellite tracker; non-drainage storage
Use of automation means at development of the lighting concept for the urban environment fragment
Authors:   Amelkina S.A. Zarodov S.N. Mikaeva S.A.
Published: October 2023

The substantiation of the use of various application tools for automation designing at development of the lighting concept for an administrative fragment of the urban environment is given.

Keywords
automation designing, computer simulation of lighting, lighting concept, computer mount of geonim ction, hierarchization of lighting design objects, utility lighting
El Conflicto trabajo-familia en relación a factores laborales en trabajadores de la salud durante la emergencia sanitaria ocasionada por el COVID-19.
Authors: De la Garza Carranza María Teresa , Ramírez Esparza Diana Soledad , Reyes Berlanga Mónica Lucía , López Lemus Jorge Armando
Published: October 2023

El artículo presenta los factores laborales que afectan la relación trabajo-familia en los trabajadores de la salud. El estudio se realizó durante la pandemia del COVID-19 en un hospital público del Estado de Guanajuato. Se comprueba a través del método de ecuaciones estructurales que existe una relación positiva y significativa entre las variables “apoyo a compañeros” y “riesgos ocupacionales” en relación a las “demandas de trabajo”. A su vez existe una relación positiva y significativa entre la variable “demandas en el trabajo” y la relación “conflicto trabajo-familia”. Se discuten también las posibles estrategias que puede emprender la organización en relación a buscar mejores alternativas para mejorar la calidad de vida de los trabajadores de la salud.
El Impacto sobre la función sexual en hombres con cáncer de mama: revisión de alcance
Authors: Vera-Alanis Yuliana , Cano-Verdugo Guillermo
Published: October 2023

Introducción: El cáncer de mama en hombres es una enfermedad poco frecuente que trae consecuencias directas relacionadas con la calidad de vida, la apariencia física y la función sexual. El objetivo fue sintetizar la información sobre la función sexual en hombres con cáncer de mama.

Materiales y métodos: Se realizó una revisión de alcance mediante la búsqueda de información disponible en las bases de datos PubMed, DOAJ, Scientific Research Publishing y National Library of Medicine. Se utilizaron conceptos relacionados con el cáncer de mama en hombres y la función sexual. Se identificaron 73 artículos y se seleccionaron 25.

Resultados: El análisis identificó cuatro tipos de repercusiones del cáncer de mama con respecto a la sexualidad: a nivel de actividad sexual, a nivel corporal, a nivel hormonal y a nivel socioemocional. Se encontró que tanto el diagnóstico como su tratamiento, especialmente el tamoxifeno, provocan disminución o ausencia de deseo sexual, disfunción eréctil, inflamación y dolor de la mama afectada, retracción y supuración del pezón, alteraciones del estado de ánimo, depresión y masculinidad afectada.

Conclusiones: Los hombres con cáncer de mama presentan condiciones adversas relacionadas con su patología y tratamiento que pueden reducir su función sexual y su calidad de vida.
Hallazgos histopatológicos en corazón, pulmones y cerebro de ratones expuestos a óxidos de plomo (greta) por vía cutánea.
Authors: Ocaña Servín Hector Lorenzo , López-Díaz H U , Jaimes-García J , Palacios-Jaimes M L , García Argueta I , Hernández Sánchez M
Published: October 2023

Introducción: México es un país con grandes depósitos naturales de plomo y se estima que el mundo genera alrededor de 12 a 130,000 toneladas/año y su principal vía de introducción al ambiente es por la atmósfera. El propósito del presente trabajo es identificar si existen lesiones en corazón, pulmones y cerebro después de una exposición cutánea al plomo en ratones.

 

Material y Métodos: Se seleccionaron 40 ratones sanos: 24 machos y 16 hembras; se les aplicó óxido de plomo (GRETA) por vía cutánea y las dosis fueron de 2,4, 6,8 y 10 mg de óxido de plomo. Se aplicó diario de lunes a sábado, estableciendo 5 lotes de 8 ratones en cada grupo; más un grupo control también de 8 ratones. Cada semana se sacrificó un ratón al azar de cada grupo y 5 ratones fallecieron antes de concluir el experimento. De cada órgano se consignó su coloración, tamaño, aspecto externo, fragilidad del tejido en general, tiempo de exposición al plomo y cambios histopatológicos en los tejidos.

 

Resultados: En los 40 ratones expuestos se presentó congestión pulmonar en grado moderado, en 33 de ellos (82%) se encontró edema pulmonar de tipo no cardiogénico y en 1 existió coágulo de fibrina. En corazón se presentó congestión vascular moderada en el 97% de los ratones (39 de ellos) y en el 5% (2 ratones) se encontró necrosis leve. En el cerebro las alteraciones fueron edema en todos los ratones expuestos, con necrosis neuronal  en el 88% (35 ratones) y gliosis neuronal reactiva en el 10% (4 ratones), con estas alteraciones los ratones perdieron coordinación en sus movimientos.

 

Discusión:

El presente trabajo mostró que el plomo aplicado por vía cutánea es capaz de absorberse. La mayoría de los mecanismos de toxicidad del plomo han sido estudiados en procesos bioquímicos y afectan sobre todo enzimas en procesos celulares. La frecuencia y la severidad de los síntomas médicos se relaciona con la concentración de plomo en la sangre.

 

Conclusiones: Por la piel la entrada del plomo inorgánico es mínima, pero el plomo orgánico pasa a través de los folículos pilosos, glándulas sebáceas y sudoríparas directo al torrente sanguíneo. El plomo constituye una parte importante de la contaminación ambiental, el empleo de este metal en la industria, hacen necesario que se controle el impacto negativo de sus acciones tanto en la salud de los seres humanos como en el ambiente.
Cadmium and copper transport in alluvial soils in the Brazilian semiarid region: column percolation and modeling
Authors: Barros Vitor Hugo de Oliveira , Alves Adriana Thays Araújo , Santos Severino Martins dos , Coutinho Artur Paiva , Lassabatere Laurent , Gondim Manuella Virgínia Salgueiro , Antonino Antonio Celso Dantas
Published: October 2023

Regarding the Brazilian textile industry, part of the northeast region stands out as the second-largest textile manufacturing hub in the country. Despite its importance, this industrial activity has been bringing relevant environmental concerns regarding the disposal of textile effluents, especially from industrial laundries. This waste contains many chemicals and among them are various types of heavy metals. To assess environmental risks associated with heavy metals, pollutant transfer needs to be investigated. This study evaluated the retention and mobility of heavy metals Cd and Cu in alluvial soil, through soil column tests. The up-flow column percolation tests were performed using a nonreactive tracer (KBr) at a concentration of 0.3 mol L
-1
and injecting a metallic solution containing Cu and Cd at 100 and 60 mg L
-1
, respectively. The injection flow rate was 0.75 mL min
-1
. The hydro-dispersive parameters were obtained by modeling the observed breakthrough curves with the convection-dispersion equation (CDE) and the two-region model, also referred to as the MIM (Mobile-IMmobile waters) model. The transport parameters were obtained from the two-site model (TSS). All elution curves were fitted to the models with the CXTFIT 2.0 program. The Two-Site Sorption Model was the best for the case studied, with R
2
of 0.985 and 0.995 for Cu and Cd, respectively. The values of R were considerably higher than the unit, presenting an average of 2.138 for Cu and 1.907 for Cd. This indicates a delay of these contaminants when leaving the column, which is caused by the interaction of these chemical compounds with the soil. The values obtained for parameter D were 3.469 for Cu and 5.205 for Cd. Thus, the metals in this study present a risk of groundwater contamination for the local alluvial aquifers. The main reason for that is the physicochemical features of the soil, such as high sand content (85 %) and low OM content (2.1 %). The results also indicated greater retention and less mobility for Cu than for Cd, pointing to a greater risk for Cd.