bluuebunny/crossref_metadata_2025 huggingface dataset:
Konceptualizacja kolorów w języku osób niewidomych od urodzenia i ociemniałych we wczesnym stadium rozwoju
Authors: Jęczeń Urszula
Published: May 2023

Przedmiotem rozważań w artykule są sposoby konceptualizacji, językowego obrazowania nazw kolorów przez dorosłe osoby niewidome od urodzenia oraz osoby ociemniałe, które utraciły wzrok między 3. a 5 rokiem życia i w swojej pamięci zachowały obrazy wzrokowe. Materiał językowy pozyskany został na drodze wywiadu, poprzez rozmowy telefoniczne. Badaniami zostały objęte osoby z grupy „Niewidomi i Niedowidzący – Bądźmy razem!” na portalu facebook.com. W badaniach wzięło udział 9 osób dobranych na zasadzie doboru losowego, w tym 4 kobiety oraz 5 mężczyzn. Z przeprowadzonych badań wynika, że wykorzystanie innych zmysłów do charakterystyki kolorów jest zależne od okresu utraty wzroku. W przypadku osób niewidomych od urodzenia najczęściej używanymi zmysłami w definiowaniu kolorów były zapach i dotyk, a najrzadziej utożsamiano barwę z dźwiękiem. U osób ociemniałych najbardziej „wyostrzonym” zmysłem w utożsamianiu barw był zmysł smaku, najmniej pomocny zaś okazał się węch.
Realizacja opisu obrazka przez dziesięciolatki z płodowym zespołem alkoholowym
Authors: Krakowiak Marta
Published: May 2023

Spożywanie alkoholu przez kobietę w czasie ciąży może skutkować wystąpieniem u jej potomka określonych zaburzeń rozwojowych, określanych mianem płodowego zespołu alkoholowego (fetal alcohol syndrome – FAS). Dotyczą one m.in. nabywania kompetencji językowych i komunikacyjnych, co objawia się np. niewłaściwą artykulacją, deficytami w zakresie fleksji i składni, a także nieprawidłowościami w tworzeniu narracyjnych form wypowiedzi. Tematem artykułu jest realizacja opisu obrazka przez dziesięciolatki z płodowym zespołem alkoholowym i ich rówieśników z grupy kontrolnej. Wyniki badań wskazują na trudności w zakresie stosowania przez dzieci z FAS następujących procedur: generalizacji zdarzeń, przestrzenności opisu, prezentatywności zdarzeń i charakterystyki elementów rzeczywistości. Osoby te, tworząc opisy obrazków, przeważnie nie stosują formuł pozwalających rozpocząć wypowiedź i prezentować treść opisywanych wydarzeń, wprowadzają w sposób nieuporządkowany poszczególne plany przestrzeni, nie stosują przy tym właściwych sformułowań, pomijają wiele istotnych szczegółów związanych z charakterystyką poszczególnych elementów rzeczywistości i relacjami, jakie zachodzą między nimi. Wymienione nieprawidłowości mają związek z ubóstwem treści i nieprawidłową strukturą tekstów konstruowanych przez dziesięciolatki z FAS.
Narración y otredad en Membrana, de Jorge Carrión
Authors: Del Río Castañeda Laro , Benito Temprano Claudia Sofía
Published: May 2023

Membrana, novela de Jorge Carrión, se presenta como un panfleto del museo del siglo XXI. Esta premisa lleva al lector contemporáneo a un estado de extrañamiento cognitivo, en el que se le requiere contemplar su presente como si fuera pasado. Sin embargo, las estrategias escogidas por Carrión para provocar desconcierto no acaban aquí: su narrador es una inteligencia artificial femenina que emplea pronombres en plural para identificarse a sí misma (o ellas mismas). Comprender a la máquina será, pues, el propósito principal de todo visitante, forzado a encontrar sentido en una historia entreverada y enunciada por un ser con otra sensación del tiempo, de la causa-efecto y de la verdad. Este artículo pretende describir los mecanismos usados por el autor para construir la voz algorítmica y explorar su potencial político y epistemológico.
“Como diría el pívot Charles Barkley, me gusta estamparme contra la realidad y ver volar los pedazos”: Entrevista a Vicente Luis Mora
Authors: Sánchez Ungidos Guillermo , Mora Vicente Luis
Published: May 2023

Entrevista al escritor, profesor y crítico literario Vicente Luis Mora.
The Role of Compassion during the Shift to Online Teaching for Language Teacher Wellbeing
Authors: Mairitsch Astrid , Babic Sonja , Mercer Sarah , Sulis Giulia , Shin Sun
Published: May 2023

Research on compassion has received increasing attention over the past decades (Seppälä et al., 2017). However, empirical studies focusing on the role of compassion for teachers still remain sparse to date. This paper reports on a study designed to investigate the wellbeing of 21 language teachers across the globe during the first wave of the COVID-19 pandemic crisis. In particular, the study sought out to examine the ways in which compassion and self-compassion contributed to the wellbeing of language teachers during this time. Data were generated through in-depth, semi-structured individual online interviews and were analyzed from a Grounded Theory perspective (Charmaz, 2006). Findings revealed that acts of compassion in the workplace and in the private lives of the teachers played a crucial role in shaping our participants’ wellbeing during this time of crisis. Furthermore, self-compassion emerged as an important factor influencing the wellbeing of teachers during the pandemic crisis. Indeed, compassion and self-compassion served as core elements in their teaching and appeared to affect their relationships with their students, colleagues, and headteachers. In the absence of compassion, the stressful and challenging situation they were already experiencing was exacerbated. These findings imply the potential benefits of compassion and self-compassion training for teachers, administrators, and policymakers to support and promote wellbeing in the educational workplace.
Protection of Privacy and Personal Data in Albania
Authors: Garunja Evis
Published: May 2023

The Protection of Personal Data became an important issue for the Albanian citizens. The new era of the protection of personal data through administrative claims started after 2008. This brought up sensitive issues like unauthorised legal processing of data on media and online portals, e-mail lack of personal data security, online data processing and online security etc. The sensibility of people increased when personal data were used for political or commercial benefits. During the COVID-19 pandemic period our lives were dominated by technology as the only means of connecting with others or continuing our normal life in abnormal conditions. On one side, human rights were suffering the most powerful restrictions and on the other,technology was gaining position faster. This paper raises questions on the relation between the protection of dignity, honour and privacy of the persons as a democratic value and technological evolution. This paper aims to introduce the Albanian legislation on the protection of privacy and personal data, legal reforms and their adaptation to international law through case law and jurisprudence. Findings, suggest the need for an international global binding act, which would facilitate the process of exchanging information, reduce administrative barriers, and increase the connection and collaboration.
Staphylococcus Aureus Meningitis: A Case Report and Literature Review
Authors: Raman Sucharita
Published: May 2023

The Blood Brain Barrier is a remarkable shield that wards off most pathogens that attempt to penetrate the brain. However, once this barrier has been breached, the body is particularly ill-equipped to deal with the infection. The cerebrospinal fluid (CSF) is a site of localized immune deficiency; it is lacking in opsonins and has little, if any, complement or immunoglobulin. In addition, the blood brain barrier now works against the body by impeding the entrance of phagocytes and antibiotics into the CSF. Hence, meningitis remains a particularly difficult condition to treat. It requires a CSF antibiotic concentration several times that which would have been required had the infection been at any other site. If the causative organism already requires a high antibiotic concentration or is susceptible only to antibiotics that do not easily penetrate the blood-brain barrier, one is then in a greater quandary. Staphylococcus aureus is one such organism. Meningitis due to S.aureus is, therefore, associated with a high mortality and morbidity. Fortunately, S.aureus is not a common cause of meningitis, accounting for only 1% to 9% of all bacterial meningitis. More that one half of these cases are associated with direct invasion of the CSF through neurosurgical intervention or trauma. This causes one to speculate that this bacterium, virulent though it may be in other locations, lacks the capacity to breach the blood-brain barrier. However, when Staphylococcal meninigitis occurs through a hematogenous route, the host is usually immunosuppressed, thus allowing overwhelming and subsequent meningeal invasion.
Sequel to the Symbiosis of the Guthrie Medical Center and the Lehigh Valley Railroad
Authors: King Arthur B.
Published: May 2023

One of the few advantages of having to have lived to a respectable old age is that one can sit back and meditate on events that have been recorded a couple of decades ago. In 1976, the author gave birth to a discourse on the influence of the Lehigh Valley Railroad on the organization and early growth of the Robert Packer Hospital.1 By 1976, the Lehigh Valley Railroad had ceased to function as a transportation company, but the Hospital was experiencing a lusty growth.
Edathil (“Ed”) Narayanan
Authors: Mahon Frank B.
Published: May 2023

Dr. Edathil Narayanan, a pediatrician and life-long learner, has retired from the Guthrie Clinic at age 61 after 26½ years of service. Ed is also a traveler - born in Rangoon, Burma, his family moved him to India when the Japanese invaded Burma. There, his father, a pathologist, served for two years with the British Army Medical Service. After medical school and training in India, Ed moved to Great Britain and finally to the United States. Along the way he indulged in his passion for education. In India, Dr. Narayanan graduated from a Catholic high school after 11 years of education and did two years of premedical studies at the University of Madras. In 1961, he graduated from the University of Madras Medical College. After a rotating internship he became a house officer, spending one year in internal medicine and one year in pediatrics at the Madras General Hospital and Children’s Hospital of Madras. Thereafter, Ed moved to England and received additional education in internal medicine and pediatrics at the West Middlesex Hospital outside of London. During this period, he took his oral and written examinations and achieved a diploma in Child Health. That diploma is equivalent to passing the American Board of Pediatrics. Dr. Narayanan continued further post-graduate studies at The Hospital for Sick Children in Glasgow, Scotland, and was a registrar in infectious disease (pediatrics and adult medicine) in Ayshire, Scotland.
Mitochondria in Programmed Cell Death: the Role of Apoptogenic Proteins
Authors: Chang Nan-Shan
Published: May 2023

Programmed cell death or apoptosis is a physiologic event that eliminates unwanted cells or tissues during development, homeostasis, aging and diseases. Numerous cytokines such as tumor necrosis factor (TNF) are able to mediate apoptosis, through the cascade of death signaling. The death signal invokes mitochondrial permeability transition (MPT) that encompasses the release of apoptogenic proteins from the intermembrane space of mitochondria to the cytosol. These proteins mediate cell death by either a caspase (cysteine protease)-dependent or caspase-independent pathway. During MPT, cytochrome c is released from mitochondria to the cytosol where it initiates a caspase-dependent death. In contrast, mitochondrial apoptosis inducing factor (AIF), a homologue of bacterial oxidoreductase, induces apoptosis in a caspase-independent manner. Bcl-2 and Bcl-xL, proteins of the Bcl-2 family, prevent MPT-mediated cytochrome c release. Bcl-xL binds to the mitochondrial voltage-dependent anion channel (VDAC) and closes the channel, thereby blocking cytochrome c release. However, two other Bcl-2 family proteins, Bak and Bax, increase the VDAC permeability and induce cytochrome c release. Thus, mitochondria are repositories of both pro-apoptotic and anti-apoptotic proteins. Release of lethal proteins from mitochondria are potentially lethal to cells.
The Wrong War by Jeffrey Record
Authors: King Arthur B.
Published: May 2023

Now that emotions have cooled somewhat and rays of reason are appearing, it may now be the time we reassess our miscalculation of what occurred in Vietnam. We should not kid ourselves that somehow we “won that war.” The conflict in the jungles of Southwest Asia is not so easily categorized.
Evaluation of Preadolescent Tobacco Use and Attitudes
Authors: VanDyke Esther M.
Published: May 2023

Tobacco use is the greatest avoidable cause of death in the United States. Nine out of ten smokers have started this deadly habit by the age of 18. The purpose of the current study is to describe rural seventh grade students’ beliefs, attitudes, and use of tobacco. Questionnaires were collected from two public school systems in Northeastern Pennsylvania (n=229). Thirty-two percent of these male and female students smoke. Only 41% of nonsmokers incorrectly believed that over half of their peers smoke cigarettes compared to 74% of smokers (p < 0.001). The smokers stated 80% of their best friends smoke compared to only 20% of the best friends of nonsmokers (p < 0.001). Students believed that the following were reasons that their peers continue to smoke: 70% it’s cool, 62% addiction, 46% you’re not supposed to, and 42% want to be like a model in an ad. Our survey results demonstrate a strong need for earlier interventions to prevent the initiation of tobacco use. We plan to complete a one-year smoking prevention program in one of the participating schools. The program is called DOC: Doctors Oughta Care. DOC is a national organization that uses humor in education to help adolescents resist the initiation of smoking.
Our Readers Respond
Authors: Mahon Frank
Published: May 2023

I read Frank’s retirement address published in the fall 1999 edition of the Guthrie Journal.
The Guthrie cDNA Resource Center
Authors: Puhl Henry L. , Aronstam Robert S. , Ikeda Stephen R.
Published: May 2023

In January 2000, the Guthrie Research Institute established a cDNA Resource Center. The mission of the center is to accelerate scientific discovery in human biology and pathology by providing full length cDNA clones of human proteins involved in signal transduction processes. The Center provides clones of human proteins that are: 1) full length; 2) sequence verified; 3) propagated in a versatile mammalian expression vector; 4) free of extraneous 3’ and 5’ untranslated regions; and 5) available in wild-type, epitope-tagged and common mutant forms (e.g., constitutively-active or dominant negative). The clones are supplied solely for non-commercial research purposes. There is no charge for these clones, although a handling and shipping fee is assessed. Between July 1 and December 31, 2000, 490 clones were shipped to customers in 65 institutions on 3 continents and the catalogue was expanded to over 130 unique clones, at least four of which have not been previously described.
THE USE OF BLOGGING TECHNOLOGY DURING THE PEDAGOGICAL PRACTICE OF FUTURE MATHEMATICS TEACHERS
Authors: Polhun Kateryna
Published: May 2023

One of the important components of the high-quality professional training of a future teacher of mathematics is an active pedagogical practice. Practice reporting involves keeping a diary of psychological and pedagogical observations. Modern information and communication technologies, in particular blogging technology, create an opportunity to improve the process of filling out a practice diary, make it more interesting and effective. The purpose of the article is to clarify the specifics of a practice blog and to formulate methodological recommendations for teachers and students regarding its management. The opportunities of using blogging technology for electronic reporting on practice are highlighted. The structure of the blog, its content, language, design, and the process of providing feedback to readers are characterized. It has been proven that blogging must be strictly planned and organized process, meet all the requirements. Following netiquette and academic integrity, legal system of Ukraine about personal data defense, respect to author’s right are emphasized. The article analyzes the typical mistakes that authors make when creating a blog, in particular, writing text only in uppercase or only lowercase letters, the presence of a significant number of language errors, unsuccessful color design of the blog, unstructured or inappropriate content of the blog, incompatibility of gadgets, lack of Internet communication etc. It was concluded that the use of blogging technology contributes to the formation of students’ ability to act reflectively, creates conditions for communicative interaction between participants in the educational process, ensures the development of critical thinking and increases the level of educational achievements of students, encourages awareness of the need for planning, self-organization and self-regulation.Keywords: practical training; student intern; observation diary; electronic reporting; information and communication technologies; blog; netiquette; academic integrity.
Changes of the Electrical Axis of the Heart and Dyslipidemia as Possible Markers of Cardiovascular Damage in Patients after COVID-19
Authors:   S.M. Kirov Military Medical Academy, Mirzoev N.T. ,   St. Petersburg, Russian Federation, Kutelev G.G. ,   S.M. Kirov Military Medical Academy; St. Petersburg, Russian Federation, Ivanov V.V. ,   S.M. Kirov Military Medical Academy; St. Petersburg, Russian Federation, Cherkashin D.V. ,   S.M. Kirov Military Medical Academy; St. Petersburg, Russian Federation, Shulenin K.S. ,   S.M. Kirov Military Medical Academy; St. Petersburg, Russian Federation, Makiev R.G. ,   S.M. Kirov Military Medical Academy; St. Petersburg, Russian Federation
Published: May 2023

Aim: To study the correlation of laboratory and instrumental indicators with the severity of the COVID-19 and to assess the dynamics of changes of the lipid profile and the electrical axis of the heart of patients in the acute period of the disease and after recovery. Design: Retrospective observational study. Materials and Methods. A retrospective analysis of medical histories of 30 young patients (18–44 years) without cardiovascular diseases, who underwent two-stage treatment at the Military Medical Academy named after S.M. Kirov with diagnoses: «COVID-19, virus identified» (U07.1, ICD-10) and «Post COVID-19 condition» (U09.9, ICD-10) in the period from April to December 2021. Results. The study found that individuals after COVID-19 had an increase in total cholesterol concentrations (6.51 [5.62–6.79] mmol/l), lowdensity lipoprotein (3.89 [3.34–4.52] mmol/l) and very low-density lipoprotein (1.06 ± 0.72 mmol/l) as opposed to acute period of COVID-19, where the lipid spectrum remained within normal values. In addition, an electrocardiogram analysis showed dynamics of the alpha angle changed from 42 ± 11 to 25 ± 17 degrees of patients after the elimination of SARS-CoV-2, with the deviation of the electrical axis of the heart to the left was detected of the first time in 5 (17%) patients after COVID-19. Conclusion. Individuals after COVID-19, who have been identified for the first time as having dyslipidemia and deviation of the electrical axis of the heart to the left, as well as high levels of inflammation markers can be considered by candidates for high-tech imaging techniques to eliminate damage of the cardiovascular system. Keywords: novel coronavirus disease; SARS-CoV-2; electrocardiography; electrical axis of the heart; dyslipidemia; cardiovascular complications.
ПСИХОЛОГІЧНА ФАСИЛІТАЦІЯ ПЕДАГОГІЧНОЇ ПРАЦІ
Authors: Маслов Валерій , Шетеля НАТАЛІЯ
Published: May 2023

The article attempts to analyze the current situation regarding insufficient psychologization of the educational process as a factor in its facilitation in educational institutions. An approach that allows to increase its effectiveness with the use of diagnosis of individual psychological features, their subsequent consideration in the process of teaching and educating students with the help of appropriate differentiated and individually adapted psychological-pedagogical methods, techniques and tools is considered.
The problem of the place and role of psychology in the scientific support of pedagogical work is becoming more and more relevant for many reasons. Psychological science itself and its applied fields have reached a sufficient level of development to ensure the interests and needs of participants in the educational process. At the same time, the subjects and subject-objects of education and upbringing are noticeably changing. Significant changes are taking place in pedagogical technologies and methods, educational methods, methods and tools. The external and essential working conditions of the teacher and lecturer are being adjusted in an evolutionary way, which requires the search for facilitation ways to support the teacher and facilitate his work.
Thus, since in general the teaching profession, like any other creative profession, is characterized by an irregular process of professional thinking, round-the-clock emotional tension during the generation of ideas, adaptation to the differential and individual characteristics of students, psychological facilitation comes to the rescue, easing physical and mental stres, minimizing time costs, allowing to use freed resources for somatic and mental health and harmonizing family life. One of the most noble types of human professional activity – teaching, teaching activity – is a priori impossible without knowledge and practical application of the achievements of the most important of the humanitarian sciences – psychology.
ЗАСТОСУВАННЯ СТУДЕНТОЦЕНТРОВАНОГО НАВЧАННЯ ПРИ ПІДГОТОВЦІ ВЧИТЕЛІВ НА ФАКУЛЬТЕТІ ІНОЗЕМНИХ МОВ
Authors: ГЛАЗУНОВА ТАМАРА , ГРАЧОВА ІРИНА , КУЗЬМІНА СВІТЛАНА
Published: May 2023

The article demonstrates the dynamics of applying a student-centered approach to the training of foreign language teachers at the Faculty of Foreign Languages, starting in 2015, when Vinnytsia Mykhailo Kotsiubynskyi State Pedagogical University joined the joint project of the Ministry of Education and Science of Ukraine and the British Council in Ukraine called "New Generation School Teacher.” The objective factors contributing to the transition to student-centeredness (the participation of teachers of the Foreign Languages Department in the project and new strategies for developing higher education in Ukraine) are considered. Quantitative and qualitative analysis of the answers of the teachers of the Foreign Languages Department to the questions of the questionnaire regarding the use of a student-centered approach in the teaching of academic disciplines under theeducational program "Secondary education. English, German languages and literature" was performed. We have concluded that the systematic use of interactive methods and approaches, the formation of students' ability to carry out self-evaluation and peer evaluation, and the development of responsibility for academic success turn the students into active participants in the educational process.
ДИДАКТИЧНІ СТРАТЕГІЇ ТА ТЕХНОЛОГІЇ ЗБАГАЧЕННЯ ЗМІСТУ ОСВІТИ СТАРШОКЛАСНИКІВ СОЦІАЛЬНИМ ДОСВІДОМ
Authors: ПАРАНЮК АННА
Published: May 2023

The article considers three didactic strategies for enriching the content of education with social experience, related to interaction with the content of educational subjects, which directly leads to the formation of individualized social experience, its self-realization, and the formation of components of social competence. The article focuses on the specifics of contextual learning, which consists in the acquisition of new knowledge due to taking into account personal educational experience, the formationof social experience through mastering the skills of expressing thoughts and judgments in a question-and-answer form. The basis of the technology of contextual learning consists of simulation-game forms and problem-situational methods of mastering the techniquesof establishing contact. The article analyzes the specific features of project-based learning: the educational process is built on the logic of activity that has a personal meaning for the student, which increases his motivation in learning; the individual pace of work on the project ensures that each student reaches the level of development; a comprehensive approach to the development of the system of educational projects contributes to balanced development of the student's basic physiological andmentalfunctions; deep, conscious assimilation of basic knowledge is ensured due to their universal use in various situations. The peculiarities of situational learning are considered as a component of the contextual organization of the educational process aimedat forming the social competence of high school students. It is noted that situational learning consists in the possibility of creating and using in the educational process of a modern school target situations of various nature: educational, personally oriented, problematic, socialization situations, ethical, conflictological. It is noted that reflective learning is also a component of the contextual organization of the educational process aimed at forming the social competence of high school students. It is indicated that reflective learning is aimed at the need to identify and understand the main components of activity (purpose, content, problems, ways and methods of solving them, obtained results) and personal development in it
ПЕДАГОГІКА ПАРТНЕРСТВА УЧНІВ І ЇХНІХ БАТЬКІВ ЯК ОСНОВА РОЗУМОВОГО ВИХОВАННЯ ШКОЛЯРІВ
Authors: Михайленко Любов , Шкільнюк Ірина
Published: May 2023

The article substantiates the expediency of introducing the pedagogy of partnership between students and their parents in the study of mathematics not only in primary school, but also in basic and specialized schools and reveals the potential of partnership interaction of students and their parents in the study of mathematics for the mental education of schoolchildren. To reveal the potential of the pedagogy of the partnership of students and their parents in the study of mathematics for the mental education of schoolchildren, we analyzed the theoretical explorations of Ukrainian scientists regarding the organization of partnership interaction of students and their parents; found out the foreign experience of partnership interaction of students and their parents in the study of mathematics; in the process of surveying parents, the attitude and readiness of schoolchildren's parents for partnership cooperation in the education of mathematics students was found out. We believe that parents can support their children in learning mathematics by taking an interest in what their children are learning and discovering with their children how what they learn in class can be applied to everyday contexts. Mathematics is everywhere, and parents can help their children make connections between what they learn at school and everyday experiences at home and in the community, such as cooking at home, shopping at the store and managing household finances. Parents can also engage their children in other ways – like enjoying math puzzles and games, etc. To ensure effective partnership between students and their parents in learning mathematics, it is important to: develop a positive attitude towards mathematics in parents, which is an important way of involving parents in cooperation; to create a home educational environment aimed at enriching students' mathematical experience, which will contribute to the mental education of students; to offer parents possible tools and ways of organizing partnership between students and their parents in learning mathematics.
Цифрове освітнє середовище в закладах освіти
Authors: Гуревич Роман , Гордійчук Галина , Кобися Володимир , Коношевський Леонід
Published: May 2023

The main directions of digitalization of the educational environment (DE) of an educational institution are related to the development of resources and material and technical base of the educational institution, formation of personnel, preparation of programme and teaching materials. The educational consequences of the educational institution's CSE are focused on increasing students' motivation to learn, forming their digital literacy and developing the digital competencies of the teacher. The article defines the prospects of the COE of an educational institution, identifies existing problems and ways to solve them, substantiates the potential of the digital educational environment of an educational institution in the formation of digital literacy of students. In the process of studying the DER of an educational institution as the basis for the formation of students' digital literacy, the authors used systemic and environmental approaches that allow considering the development of technical, informational, communicative, social, value, legal, cognitive and other aspects of digital literacy in a single space-time aspect. Based on the analysis of the positive and negative experience of creating a DLC of an educational institution and the characteristics of its functionality, the main problems of digitalization of education and possible ways to solve them are identified; potential risks and threats to the implementation of the educational process in the DLC are diagnosed. The role of DLC in the formation of digital literacy of students is determined. The digital educational environment is positioned as an indispensable attribute of the formation of digital literacy of students, the environment of their digital socialization. The role of the DEC of an educational institution in the organization of personality-oriented education in order to improve the quality of education, social relevance and professional success of students is clarified.
ОРГАНІЗАЦІЯ ШКІЛЬНОЇ ОСВІТИ В УМОВАХ НАДЗВИЧАЙНИХ СИТУАЦІЙ ВОЄННОГО ХАРАКТЕРУ: АНАЛІЗ СВІТОВОГО ДОСВІДУ
Authors: Акімова Ольга , КОЛОМІЄЦЬ ДМИТРО , БАБЧУК ЮРІЙ , ГРИЦАК АНАТОЛІЙ
Published: May 2023

The article analyzes the experience of organizing education in countries affected by military conflicts. The authors point to the new role of education in the conditions of emergency situations of a military nature and to the new challenges facing education in the post-war period. Based on the analysis of European documents regulating education in emergency situations, a strategic model of education organization has been determined. The study points to the challenges of teacher preparedness and the psychosocial needs of students during emergencies.Taking into account the insufficiency of scientific works on the training teachers for the organization of education in the conditions of emergency situations of a military nature, the authors outlined the prospects for further
 

 
research (the study of the best experiences of Ukrainian teachers who continue the educational process during thewar; observation of students and conversations with them in order to determine their psychosocial needs; development of psycho-corrective methods for psychosocial support of all participants in the educational process; adjustment of educational programs and the content of educational disciplines in order to train teachers for the organization of the educational process in the conditions of emergencies of various nature), which may be useful for the modernization of the education content in Ukraine in the post-war period.
International Development Partner's Role in the Empowerment of Women Through Education in South Punjab (2001-2020)
Authors: Noureen Ishrat , Yasmeen Robina
Published: May 2023

Role of international development partners to empower women through the provision of education in South Punjab (2001-2020) has been significant for the promotion of gender equality and empowering women in the region. The study utilizes a qualitative research design and employs the document analysis method to collect data from relevant documents including reports and publications by international development partners and government agencies. The data is analyzed using thematic analysis and the findings are presented in the form of themes and sub-themes. In conclusion, this study highlights the critical role of international development partners in the promotion of the rights of women through the provision of education facilities and gender equality in South Punjab. These challenges include cultural and societal norms, inadequate funding, and lack of political will. The study recommends that international development partners continue to work in collaboration with government agencies and social organizations to address these challenges and promotion of rights of women and gender equality in the region.
Critical Features of Science Education: A Comparison between Global and National Education Policy for Rohingya Refugee Children in Bangladesh
Authors: Rahman Shukufe , Buck Gayle
Published: May 2023

Rohingya refugee children, a persecuted minority, should have the opportunity to acquire the level of scientific literacy necessary to survive and thrive in an increasingly scientific world. Unfortunately, our understanding of the role science education holds in the various educational policies that guide the programming for Rohingya refugee children in the camps in Bangladesh is minimal. The purpose of this study was to enhance that understanding. A vertical axes comparative case study approach was used to compare and analyze the policies at the global and national levels to elucidate the existing inclusion or lack of science and scientific literacy for the Rohingya refugee education system. Findings showed that the educational policies fall short in supporting and promoting science and scientific literacy along with numeracy and literacy. Based on evidence on comparison between global and national policies for education for Rohingya refugee children, this study led to the development of recommendations for enabling policies and inclusive science and scientific literacy can pave the path for a better future for the prosecuted Rohingya refugee children.
Altered Anterior Insular Metabolic Connectivity in Asymptomatic MAPT P301L Carriers
Authors: Chu Min , Jiang Deming , Liu Li , Nie Binbin , Cui Bo , Wang Yihao , Rosa-Neto Pedro , Wu Liyong
Published: May 2023

Background:

The insula is the predominant brain region impaired in behavioral variant frontotemporal dementia (bvFTD). However, structural and functional changes in the sub-insula in the asymptomatic stage of bvFTD are unknown.

Objective:

To describe structural and functional changes in insula subregions in asymptomatic carriers of the P301L mutation of the microtubule-associated protein tau ( MAPT) gene and patients with bvFTD.

Methods:

Six asymptomatic MAPT P301L mutation carriers and 12 MAPT negative control subjects of the same pedigree were enrolled, along with 30 patients with a clinical diagnosis of bvFTD and 30 matched controls. All subjects underwent hybrid positron emission tomography/magnetic resonance imaging. Atlas-based parcellation using a fine-grained Brainnetome Atlas was conducted to assess gray matter (GM) volume, metabolism, and metabolic connectivity in the sub-insula (region of interest).

Results:

There was no significant GM atrophy or hypometabolism in insula subregions in asymptomatic MAPT P301L carriers, although decreased metabolic connectivity between vIa-middle temporal gyrus, vIa-temporal poles, dIa-middle temporal gyrus and dIa-temporal poles; and increased connectivity between vIa-orbitofrontal, vIa-dorsal lateral superior frontal gyrus, and dIa-orbitofrontal and dIa-dorsal lateral superior frontal gyrus were observed. Patients with bvFTD had significant atrophy and hypometabolism in all insula subregions and decreased metabolic connectivity in the whole brain, including vIa/dIa-middle temporal and vIa/dIa-temporal poles. The standardized uptake value ratios of vIa and dIa were negatively associated with Frontal behavior inventory disinhibition scale scores.

Conclusion:

Metabolic connectivity is altered in vIa and dIa subregions of the sub-insula in MAPT P301L mutation carriers before the occurrence of atrophy, hypometabolism, and clinical symptoms.
Comparison of Clinical, Genetic, and Pathologic Features of Limbic and Diffuse Transactive Response DNA-Binding Protein 43 Pathology in Alzheimer’s Disease Neuropathologic Spectrum
Authors: Carlos Arenn F. , Machulda Mary M. , Rutledge Matthew H. , Nguyen Aivi T. , Reichard R. Ross , Baker Matthew C. , Rademakers Rosa , Dickson Dennis W. , Petersen Ronald C. , Josephs Keith A.
Published: May 2023

Background:

Increasing evidence suggests that TAR DNA-binding protein 43 (TDP-43) pathology in Alzheimer’s disease (AD), or AD-TDP, can be diffuse or limbic-predominant. Understanding whether diffuse AD-TDP has genetic, clinical, and pathological features that differ from limbic AD-TDP could have clinical and research implications.

Objective:

To better characterize the clinical and pathologic features of diffuse AD-TDP and differentiate it from limbic AD-TDP.

Methods:

363 participants from the Mayo Clinic Study of Aging, Alzheimer’s Disease Research Center, and Neurodegenerative Research Group with autopsy confirmed AD and TDP-43 pathology were included. All underwent genetic, clinical, neuropsychologic, and neuropathologic evaluations. AD-TDP pathology distribution was assessed using the Josephs 6-stage scale. Stages 1–3 were classified as Limbic, those 4–6 as Diffuse. Multivariable logistic regression was used to identify clinicopathologic features that independently predicted diffuse pathology.

Results:

The cohort was 61% female and old at onset (median: 76 years [IQR:70–82]) and death (median: 88 years [IQR:82–92]). Fifty-four percent were Limbic and 46% Diffuse. Clinically, ∼10–20% increases in odds of being Diffuse associated with 5-year increments in age at onset ( p = 0.04), 1-year longer disease duration ( p = 0.02), and higher Neuropsychiatric Inventory scores ( p = 0.03), while 15-second longer Trailmaking Test-B times ( p = 0.02) and higher Block Design Test scores ( p = 0.02) independently decreased the odds by ~ 10–15%. There was evidence for association of APOE ɛ4 allele with limbic AD-TDP and of TMEM106B rs3173615 C allele with diffuse AD-TDP. Pathologically, widespread amyloid-β plaques (Thal phases: 3–5) decreased the odds of diffuse TDP-43 pathology by 80–90%, while hippocampal sclerosis increased it sixfold ( p < 0.001).

Conclusion:

Diffuse AD-TDP shows clinicopathologic and genetic features different from limbic AD-TDP.
Retinal Functional and Structural Neural Indices: Potential Biomarkers for the Monitoring of Cerebral Neurodegeneration: The Maastricht Study
Authors: van der Heide Frank C.T. , Mokhtar Sara , Khanna Anjani , Said Mozhda , Henry Ronald M.A. , Kroon Abraham A. , Dagnelie Pieter C. , Eussen Simone J.P.M. , Berendschot Tos T.J.M. , Schouten Jan S.A.G. , Schram Miranda T. , van der Kallen Carla J.H. , van Greevenbroek Marleen M.J. , Wesselius Anke , Savelberg Hans H.C.M. , Schaper Nicolaas C. , Webers Carroll A.B. , Stehouwer Coen D.A.
Published: May 2023

Background:

If retinal indices of neurodegeneration are to be biomarkers for the monitoring of cerebral neurodegeneration, it is important to establish whether potentially modifiable risk factors for dementia are associated with retinal neurodegenerative changes.

Objective:

To study associations of dementia risk factors with retinal sensitivity, an index of retinal neural function, and retinal nerve fiber layer (RNFL) thickness, an index of retinal neural structure.

Methods:

We used cross-sectional data from The Maastricht Study (up to 5,666 participants, 50.5% men, mean age 59.7), and investigated associations with regression analyses (adjusted for potential confounders).

Results:

Most risk factors under study (i.e., hyperglycemia, unhealthy diet, lower cardiorespiratory fitness, smoking, alcohol consumption, and hypertension) were significantly associated with lower retinal sensitivity and lower RNFL thickness.

Conclusion:

Findings of this population-based study support the concept that retinal neural indices may be biomarkers for the monitoring of therapeutic strategies that aim to prevent early-stage cerebral neurodegeneration and, ultimately, dementia.
Combination of linguistic Z-numbers and IF-THEN rules based on rectangular coordinate system
Authors: Chen Huakun , Jia Qianlei , Huang Wei , Shi Jingping , Safwat Ehab
Published: May 2023

There is a growing body of literature that recognises the importance of Z-numbers proposed by Prof Zadeh. However, due to the complicated structure and short presentation time, many unknowns about Z-numbers still exist. To fill these gaps, this study aims to make use of rectangular coordinate system to express linguistic Z-numbers. Simultaneously, this study sets out to design a score function to quantify the information contained in different Z-numbers. Subsequently, distance measure and similarity measure are also presented from the perspective of coordinate system. Besides, linguistic discrete Z-numbers and belief rule base (BRB) model are combined to construct a novel reasoning model on the basis of implication operators. To verify the validity of the proposed method, three representative examples of epidemic level assessment, multicriteria group decision-making (MCGDM), and network security assessment are employed. The comparison with other widely used methods are performed to further demonstrate the superiority of the proposed method.
Dyslipidemia in Muscular Dystrophy: A Systematic Review and Meta-Analysis
Authors: Sun Zeren , Wang Xindi , White Zoe , Dormuth Colin , Morales Fernando , Bernatchez Pascal
Published: May 2023

Background:

Muscular dystrophies (MDs) are characterized by chronic muscle wasting but also poorly understood metabolic co-morbidities. We have recently shown that Duchenne MD (DMD) patients, dogs and asymptomatic carriers are affected by a new form of dyslipidemia that may exacerbate muscle damage.

Objective:

We aimed to perform a systematic review and meta-analysis for evidence that other types of MDs are associated with dyslipidemia compared to healthy controls.

Methods:

Search was conducted using MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials for reports that compare plasma/serum lipids from MD patients and controls, and meta-analysis of cross-sectional studies quantifying total cholesterol, high-density lipoprotein, low density lipoprotein and triglycerides was performed.

Results:

Out of 749 studies, 17 met our inclusion criteria for meta-analysis. 14 of the 17 studies (82%) included investigated myotonic dystrophy (DM); other studies were on pseudohypertrophic MD (PMD) or DMD. As a whole, MD individuals had significantly higher levels of circulating total cholesterol (Hedges’ g with 95% confidence interval [CI], 0.80 [0.03 – 1.56]; p = 0.04) and triglycerides (Hedges’ g with 95% confidence interval [CI], 2.28[0.63 – 3.92]; p = 0.01) compared to controls. Meta-regression analysis showed the percentage of male gender was significantly associated with the difference in total cholesterol (beta = 0.05; 95% CI, – 0.02 to 0.11; p = 0.043) and high-density lipoprotein (beta = – 9.38; 95% CI, – 16.26 to – 2.50; p = 0.028).

Conclusions:

MD is associated with significantly higher circulating levels of total cholesterol and triglycerides. However, caution on the interpretation of these findings is warranted and future longitudinal research is required to better understand this relationship.
Eksekusi Putusan Pailit Atas Perusahaan Modal Asing Di Indonesia
Authors: Rifki Putra Muhammad Rendy
Published: May 2023

A bankruptcy Decision is a decision which states that a company is normatively bankrupt. Decisions were issued by the Indonesian Commercial Court and given to foreign companies in Indonesia due to the end of PKPU. This research is normative legal research, with a legal approach. The data sources are primary and secondary legal materials, which will be analyzed qualitatively. From this research, it is known that normatively a foreign capital company in Indonesia can be declared bankrupt by the Commercial Court if it fulfills the elements in Article 2 Paragraph (1) and Article 3 Paragraph (4) of the Bankruptcy Law. The problem that arises then is the execution stage of the decision. During the management and settlement of bankrupt assets, it is certain that other legal problems will arise, namely if the assets of the bankrupt debtor in Indonesia are not sufficient so that the debtor's assets are outside the jurisdiction of Indonesia. To overcome this problem, the government needs to enter into international agreements bilaterally and multilaterally, and the government also needs to ratify the Uncitral Model Law on Cross-Border with Guide to Enactment agreement made by the United Nations which can apply to fellow countries that ratify the regulation.
Authors: Mustaqim Mustaqim
Published: May 2023

Mediasi desa sebagai salah satu upaya penyelesaian sengketa menjadi hal penting untuk dilakukan oleh masyarakat. Hal ini dikarenakan mediasi pada masyarakat desa menekankan harmonisasi masyarakat serta nilai-nilai kearifan lokal. Penelitian ini berorientasi menjelaskan pentingnya menghidupkan kembali praktik mediasi di tingkat desa yang bertujuan untuk menjaga harmonisasi masyarakat serta bagaimana formulasi hukum yang tepat untuk menghidupkan kembali praktik mediasi di tingkat desa. Penelitian ini merupakan penelitian yuridis-normatif yang berupaya menganalisis isu hukum dengan bahan hukum primer, sekunder, dan non-hukum. Hasil penelitian menunjukkan bahwa Upaya dan urgensi untuk menghidupkan kembali penyelesaian sengketa melalui mediasi dari kepala desa perlu dilakukan karena terdapat esensi nilai moral dan menjaga harmonisasi di masyarakat. Formulasi hukum untuk menghidupkan kembali praktik mediasi di tingkat desa adalah dengan mengoptimalkan teori sistem hukum Lawrence M. Friedman yang meliputi: substansi, struktur, dan budaya hukum
Peran Mediator Dalam Penanganan Perkara Perceraian: Kajian Dalam Perspektif Teori Ishlah
Authors: Nastangin Nastangin Nastangin , Latifa Soraya Al , Huda Muhammad Chairul
Published: May 2023

This study aims to determine the role of the mediator at the Islamic Legal Consultation and Assistance Institute (LKBHI) IAIN Salatiga in handling divorce cases. This research is a qualitative research. Researchers go directly to the field (fieldwork research) to explore comprehensive data on research subjects, namely LKBHI IAIN Salatiga. The method of collecting data in this research was observation and in-depth interviews (in depth interviews). The analysis used is deductive-inductive. The theory in this study uses the theory of ishlah (peace). The results of this research are first, the mediator of LKBHI IAIN Salatiga experienced several obstacles in handling divorce, that the complexity of the problems of the litigants, so that in mediation it became more difficult to reconcile even though some were successful and some were not. Second, the implementation of mediation according to the rules in PERMA No. 1 of 2016. Third, the role of the mediator is basically in accordance with the theory of ishlah (peace). The novelty of this research is the discovery of efforts that can be taken by mediators in making efforts to making peace between the litigants. The mediator can take several approaches, namely providing religious spirituality values, the importance of children's future, nostalgia for the days of marriage, framing problems and caucuses.