bluuebunny/crossref_metadata_2025 huggingface dataset:
TNF-α Receptor Inhibitor Alleviates Metabolic and Inflammatory Changes in a Rat Model of Ischemic Stroke
Authors: Lin Shih-Yi , Wang Ya-Yu , Chang Cheng-Yi , Wu Chih-Cheng , Chen Wen-Ying , Liao Su-Lan , Chen Chun-Jung
Published: May 2021

Hyperglycemia and inflammation, with their augmented interplay, are involved in cases of stroke with poor outcomes. Interrupting this vicious cycle thus has the potential to prevent stroke disease progression. Tumor necrosis factor-α (TNF-α) is an emerging molecule, which has inflammatory and metabolic roles. Studies have shown that TNF-α receptor inhibitor R-7050 possesses neuroprotective, antihyperglycemic, and anti-inflammatory effects. Using a rat model of permanent cerebral ischemia, pretreatment with R-7050 offered protection against poststroke neurological deficits, brain infarction, edema, oxidative stress, and caspase 3 activation. In the injured cortical tissues, R-7050 reversed the activation of TNF receptor-I (TNFRI), NF-κB, and interleukin-6 (IL-6), as well as the reduction of zonula occludens-1 (ZO-1). In the in vitro study on bEnd.3 endothelial cells, R-7050 reduced the decline of ZO-1 levels after TNF-α-exposure. R-7050 also reduced the metabolic alterations occurring after ischemic stroke, such as hyperglycemia and increased plasma corticosterone, free fatty acids, C reactive protein, and fibroblast growth factor-15 concentrations. In the gastrocnemius muscles of rats with stroke, R-7050 improved activated TNFRI/NF-κB, oxidative stress, and IL-6 pathways, as well as impaired insulin signaling. Overall, our findings highlight a feasible way to combat stroke disease based on an anti-TNF therapy that involves anti-inflammatory and metabolic mechanisms.
UHPLC-ESI-QTOF-MS/MS Metabolite Profiling of the Antioxidant and Antidiabetic Activities of Red Cabbage and Broccoli Seeds and Sprouts
Authors: Aloo Simon-Okomo , Ofosu Fred-Kwame , Daliri Eric-Banan-Mwine , Oh Deog-Hwan
Published: May 2021

The antioxidant and antidiabetic properties and metabolite profiling of ethanol extracts of red cabbage (RC) and broccoli (BR) seeds and sprouts were investigated in this study. The total phenolic, flavonoid, and saponin contents were in the ranges of 385.4–480.4 mg FAE/100 g, 206.9–215.6 mg CE/100 g, and 17.8–27.0 mg soysaponin BE/100 g, respectively. BR seed had the highest total phenolic (480.4 mg FAE/100 g) and flavonoid (216.9 mg CE/100 g) contents, whereas BR sprout had the highest saponin content (27.0 soysaponin BE/100g). RC sprout demonstrated the highest antioxidant capacity, with DPPH and ABTS radical scavenging activity levels of 71.5% and 88.5%, respectively. Furthermore, BR and RC sprouts showed the most potent inhibition against α-glucosidase (91.32% and 93.11%, respectively) and pancreatic lipase (60.19% and 61.66%, respectively). BR seed (60.37%) demonstrated the lowest AGE inhibition. A total of 24 metabolites, predominantly amino acids and phenolic compounds, were characterized using UHPLC-QTOF-MS/MS. Germination not only improved the levels of metabolites but also resulted in the synthesis of new compounds. Therefore, these findings show that germination effectively enhanced the functional properties and metabolite profiles of broccoli and red cabbage seeds, making their sprouts more applicable as functional ingredients.
Bit Streaming Processing Algorithms for Intelligent Hardware Converters
Authors: Bureneva Olga , Kupriyanov Mikhail , Safyannikov Nikolay
Published: May 2021

The need to transfer the primary data conversions close to the sensors, to the endpoints of monitoring systems, as well as in IoT terminal devices makes the development of new approaches to computing and the design of appropriate algorithms relevant. The article shows stream processing algorithms that provide functional transformations of signals presented in bit stream form (single pulse streams, PWM signal streams) and binary codes at the same time. In such algorithms, the computational process is based on discretization, pulse frequency sweep and pulse-width sweep of codes as well as organization of parallel-serial processing. The suggested principles of algorithm organization are based on the fact that the computation is considered not as an event associated with calculation but as a continuous process of a result formation. The transition to algorithmic representations proposed by the authors makes it possible to obtain universal behavioral descriptions, independently of the specific hardware on which their implementation is performed.
Sex-Specific Differences in the Relationship between Insulin Resistance and Adiposity Indexes in Children and Adolescents with Obesity
Authors: Calcaterra Valeria , Verduci Elvira , Schneider Laura , Cena Hellas , De Silvestri Annalisa , Vizzuso Sara , Vinci Federica , Mameli Chiara , Zuccotti Gianvincenzo
Published: May 2021

New indexes of adiposity have been introduced to evaluate body-fat distribution and cardiometabolic risk. However, data on the correlation between Insulin Resistance (IR) and these new indexes are limited. We therefore evaluated the relationship between IR and adiposity indexes in children and adolescents with obesity, focusing on gender differences. We retrospectively enrolled 586 patients with obesity (10.80 ± 2.63; 306F/279M). As adiposity indexes we considered body mass index (BMI), BMI-z score, WC, waist-to-height ratio (WHtR), a body shape index (ABSI), triponderal mass index (TMI), visceral adiposity index (VAI) and conicity index (ConI). The homeostasis model assessment for insulin resistance (HOMA-IR), HOMA of percentage β-cell function (HOMA-β), quantitative insulin sensitivity check index (QUICKI), and triglyceride and glucose index (TyG-index) were measured and recorded as IR surrogates. In both sexes, WC and VAI significantly correlated with all IR measurements (p < 0.001). BMI significantly correlated (p < 0.001) with all IR parameters except for the TyG-index in females. Fat mass and TMI correlated with IR parameters only in females, BMI-z score with IR markers except for HOMA-β in males, WHtR with HOMA-β in both sexes (p < 0.05), free fat mass with HOMA-IR and QUICKI only in females (p < 0.01), ConI correlated with the TyG index in females (p = 0.01). Tryglicerides and SBP were correlated with all IR measurements (p < 0.001), in both sexes. Correlations between different sex parameters were significantly more evident in middle puberty. The relationship between IR surrogates and obesity indexes is influenced by gender in pediatrics. Sex-specific differences in obesity-related complications should be considered in preventive intervention decision-making.
Focusing on Autism Spectrum Disorder in Xia–Gibbs Syndrome: Description of a Female with High Functioning Autism and Literature Review
Authors: Della Vecchia Stefania , Milone Roberta , Cagiano Romina , Calderoni Sara , Santocchi Elisa , Pasquariello Rosa , Battini Roberta , Muratori Filippo
Published: May 2021

Background: Xia–Gibbs syndrome (XGS) is a rare disorder caused by de novo mutations in the AT-Hook DNA binding motif Containing 1 (AHDC1) gene, which is characterised by a wide spectrum of clinical manifestations, including global developmental delay, intellectual disability, structural abnormalities of the brain, global hypotonia, feeding problems, sleep difficulties and apnoea, facial dysmorphisms, and short stature. Methods: Here, we report on a girl patient who shows a peculiar cognitive and behavioural profile including high-functioning autism spectrum disorder (ASD) without intellectual disability and provide information on her developmental trajectory with the aim of expanding knowledge of the XGS clinical spectrum. On the basis of the current clinical case and the literature review, we also attempt to deepen understanding of behavioural and psychiatric manifestations associated with XGS. Results: In addition to the patient we described, a considerable rate of individuals with XGS display autistic symptoms or have been diagnosed with an autistic spectrum disorder. Moreover, the analysis of the few psychopathological profiles of patients with XGS described in the literature shows a frequent presence of aggressive and self-injurious behaviours that could be either an expression of autistic functioning or an additional symptom of the ASD evolution. A careful investigation of the abovementioned symptoms is therefore required, since they could represent a “red flag” for ASD.
Packaging of Fresh Sliced Mushrooms with Essential Oils Vapours: A New Technology for Maintaining Quality and Extending Shelf Life
Authors: López-Gómez Antonio , Ros-Chumillas María , Navarro-Martínez Alejandra , Barón Marta , Navarro-Segura Laura , Taboada-Rodríguez Amaury , Marín-Iniesta Fulgencio , Martínez-Hernández Ginés Benito
Published: May 2021

The use of vapour of essential oils (EOs) through an innovative pilot-plant packaging device was studied to preserve the quality of sliced mushrooms during storage. A mix of EOs (eugenol, bergamot EO, and grapefruit EO) was vaporized (100 and 125 µL L−1) and applied during packaging of sliced mushrooms under modified atmosphere packaging (MAP); then, the product quality was studied during cold storage up to 12 days. The highest colour changes of EOs125 samples, which were observed in the mushroom stipe, were not observed with the EOs100 atmosphere. Thus, the high polyphenoloxidase activity observed in untreated samples after 5–7 days was highly controlled with the vapour EOs atmospheres. Furthermore, the visual appearance scores of EOs100 samples were still over the limit of usability, while untreated samples were already below this threshold after 5 days of storage. A strong bacteriostatic effect was achieved with vapour EOs, reducing the Pseudomonas spp. (the main microbial genus in cultivated mushrooms) growth by ≈1.7 log CFU g−1, regardless of the EOs dose, after 12 days. The activity of phenyl ammonia lyase was also reduced up to ≈0.4 enzymatic units with the EOs100 treatment. Conclusively, packaging of sliced mushrooms under an atmosphere enriched with 100 µL L−1 EOs vapour highly controlled the quality loss of sliced mushrooms owing to their enzymatic inhibition and high bacteriostatic effect.
Cartesian Mesh Generation with Local Refinement for Immersed Boundary Approaches
Authors: Di Angelo Luca , Duronio Francesco , De Vita Angelo , Di Mascio Andrea
Published: May 2021

In this paper, an efficient and robust Cartesian Mesh Generation with Local Refinement for an Immersed Boundary Approach is proposed, whose key feature is the capability of high Reynolds number simulations by the use of wall function models, bypassing the need for accurate boundary layer discretization. Starting from the discrete manifold model of the object to be analyzed, the proposed model generates Cartesian adaptive grids for a CFD simulation, with minimal user interactions; the most innovative aspect of this approach is that the automatic generation is based on the segmentation of the surfaces enveloping the object to be analyzed. The aim of this paper is to show that this automatic workflow is robust and enables to get quantitative results on geometrically complex configurations such as marine vehicles. To this purpose, the proposed methodology has been applied to the simulation of the flow past a BB2 submarine, discretized by non-uniform grid density. The obtained results are comparable with those obtained by classical body-fitted approaches but with a significant reduction of the time required for the mesh generation.
An FTC Design via Multiple SOGIs with Suppression of Harmonic Disturbances for Five-Phase PMSG-Based Tidal Current Applications
Authors: Liu Zhuo , Tang Tianhao , Houari Azeddine , Machmoum Mohamed , Benkhoris Mohamed Fouad
Published: May 2021

This paper firstly adopts a fault accommodation structure, a five-phase permanent magnet synchronous generator (PMSG) with trapezoidal back-electromagnetic forces, in order to enhance the fault tolerance of tidal current energy conversion systems. Meanwhile, a fault-tolerant control (FTC) method is proposed using multiple second-order generalized integrators (multiple SOGIs) to further improve the systematic fault tolerance. Then, additional harmonic disturbances from phase current or back-electromagnetic forces in original and Park’s frames are characterized under a single-phase open condition. Relying on a classical field-oriented vector control scheme, fault-tolerant composite controllers are then reconfigured using multiple SOGIs by compensating q-axis control commands. Finally, a real power-scale simulation setup with a gearless back-to-back tidal current energy conversion chain and a small power-scale laboratory prototype in machine side are established to comprehensively validate feasibility and fault tolerance of the proposed method. Simulation results show that the proposed method is able to suppress the main harmonic disturbances and maintain a satisfactory fault tolerance when third harmonic flux varies. Experimental results reveal that the proposed model-free fault-tolerant design is simple to implement, which contributes to better fault-tolerant behaviors, higher power quality and lower copper losses. The main advantage of the multiple SOGIs lies in convenient online implementation and efficient multi-harmonic extractions, without considering system’s model parameters. The proposed FTC design provides a model-free fault-tolerant solution to the energy harvested process of actual tidal current energy conversion systems under different working conditions.
Global Transcriptome Profiling Identified Transcription Factors, Biological Process, and Associated Pathways for Pre-Harvest Aflatoxin Contamination in Groundnut
Authors: Soni Pooja , Pandey Arun K. , Nayak Spurthi N. , Pandey Manish K. , Tolani Priya , Pandey Sarita , Sudini Hari K. , Bajaj Prasad , Fountain Jake C. , Singam Prashant , Guo Baozhu , Varshney Rajeev K.
Published: May 2021

Pre-harvest aflatoxin contamination (PAC) in groundnut is a serious quality concern globally, and drought stress before harvest further exacerbate its intensity, leading to the deterioration of produce quality. Understanding the host–pathogen interaction and identifying the candidate genes responsible for resistance to PAC will provide insights into the defense mechanism of the groundnut. In this context, about 971.63 million reads have been generated from 16 RNA samples under controlled and Aspergillus flavus infected conditions, from one susceptible and seven resistant genotypes. The RNA-seq analysis identified 45,336 genome-wide transcripts under control and infected conditions. This study identified 57 transcription factor (TF) families with major contributions from 6570 genes coding for bHLH (719), MYB-related (479), NAC (437), FAR1 family protein (320), and a few other families. In the host (groundnut), defense-related genes such as senescence-associated proteins, resveratrol synthase, seed linoleate, pathogenesis-related proteins, peroxidases, glutathione-S-transferases, chalcone synthase, ABA-responsive gene, and chitinases were found to be differentially expressed among resistant genotypes as compared to susceptible genotypes. This study also indicated the vital role of ABA-responsive ABR17, which co-regulates the genes of ABA responsive elements during drought stress, while providing resistance against A. flavus infection. It belongs to the PR-10 class and is also present in several plant–pathogen interactions.
Osmolyte Signatures for the Protection of Aspergillus sydowii Cells under Halophilic Conditions and Osmotic Shock
Authors: Rodríguez-Pupo Eya Caridad , Pérez-Llano Yordanis , Tinoco-Valencia José Raunel , Sánchez Norma Silvia , Padilla-Garfias Francisco , Calahorra Martha , Sánchez Nilda del C. , Sánchez-Reyes Ayixón , Rodríguez-Hernández María del Rocío , Peña Antonio , Sánchez Olivia , Aguirre Jesús , Batista-García Ramón Alberto , Folch-Mallol Jorge Luis , Sánchez-Carbente María del Rayo
Published: May 2021

Aspergillus sydowii is a moderate halophile fungus extensively studied for its biotechnological potential and halophile responses, which has also been reported as a coral reef pathogen. In a recent publication, the transcriptomic analysis of this fungus, when growing on wheat straw, showed that genes related to cell wall modification and cation transporters were upregulated under hypersaline conditions but not under 0.5 M NaCl, the optimal salinity for growth in this strain. This led us to study osmolyte accumulation as a mechanism to withstand moderate salinity. In this work, we show that A. sydowii accumulates trehalose, arabitol, mannitol, and glycerol with different temporal dynamics, which depend on whether the fungus is exposed to hypo- or hyperosmotic stress. The transcripts coding for enzymes responsible for polyalcohol synthesis were regulated in a stress-dependent manner. Interestingly, A. sydowii contains three homologs (Hog1, Hog2 and MpkC) of the Hog1 MAPK, the master regulator of hyperosmotic stress response in S. cerevisiae and other fungi. We show a differential regulation of these MAPKs under different salinity conditions, including sustained basal Hog1/Hog2 phosphorylation levels in the absence of NaCl or in the presence of 2.0 M NaCl, in contrast to what is observed in S. cerevisiae. These findings indicate that halophilic fungi such as A. sydowii utilize different osmoadaptation mechanisms to hypersaline conditions.
Do Financial Development and Economic Openness Matter for Economic Progress in an Emerging Country? Seeking a Sustainable Development Path
Authors: Hussain Ammara , Oad Ammar , Ahmad Munir , Irfan Muhammad , Saqib Farhan
Published: May 2021

While emerging economies face the challenge of competing with developed nations, they are capable of catching up to the developed world. In this context, financial development and the degree of economic openness may provide better living conditions for the current generation without giving up future generations’ prosperity. Therefore, this research’s prime intention is to investigate the impact of economic openness and financial development on economic progress, employing Pakistan’s time-series data from 1975–2018. To examine the long-term association between economic openness, financial development, and economic progress, Autoregressive Distributed Lag (ARDL) cointegration tests were performed and the results present a long-term association between these variables. Findings from ARDL estimates indicate that the relationship between financial development and economic progress is significantly positive in the long term. Contrastingly, the relationship between economic openness and economic progress is significantly positive in the short term. A fully modified ordinary least square technique was applied to check the robustness of the long-term links. The Granger causality test revealed that economic progress is motivated by both economic openness and financial development in an emerging economy such as Pakistan. Thus, policies boosting financial development and economic openness are proposed to put the emerging economies on a path of sustainable economic development.
System Identification and Controller Design of a Novel Autonomous Underwater Vehicle
Authors: Wu Baoju , Han Xiaowei , Hui Nanmu
Published: May 2021

Autonomous underwater vehicle is an effective tool for humans to explore the ocean. It can be used for the monitoring of underwater structures and facilities, which puts forward more accurate and stable requirements for the system operation of the autonomous underwater vehicle. This paper studies the system and structural design, including the parameter identification design and control system design, of a novel autonomous underwater vehicle called “Arctic AUV”. The dynamic mathematical model of the “Arctic AUV” was established, and the system parameter identification method based on the multi-sensor least squares centralized fusion algorithm was proposed. The simplification of the mathematical model of the robot was theoretically derived, and the online parameter identification and motion control were combined, so that the robot could cope with the influence of the arctic water velocity and external turbulence. Based on the hybrid control scheme of adaptive PID and predictive control, the accurate motion control of the “Arctic AUV” was realized. A prototype of “Arctic AUV” was developed, and system parameter identification experiments were carried out in indoor pool water. Hybrid adaptive and predictive control experiments were also carried out. The validity of the parametric design method in this paper was verified, and by comparative experiment, the effect of the control method proposed in this paper was better than the traditional method.
Experimental Measurement of Absorption Coefficients for Effective Erbium-Doping Concentration to Optimize Few-Mode Erbium-Doped Fiber Amplifiers with Low Differential Mode Gain
Authors: Xu Yan , Wu Baojian , Jiang Xinrui , Guo Haomiao , Wen Feng
Published: May 2021

According to the analytical expression for modal gain of few-mode erbium-doped fiber amplifiers (FM-EDFAs), we propose a method of measuring the absorption loss coefficients of few-mode signals in few-mode erbium-doped fibers (FM-EDFs) by extrapolating the mode–gain curve dependent on the average population inversion. The absorption loss coefficient of an FM-EDF was measured in our experimental platform and used to estimate the effective erbium-ion doping concentration. The feasibility of the extrapolation method was verified by simulation and comparison with the transmission method. Furthermore, the FM-EDFAs with high modal gain and low differential mode gain (DMG) could be optimized by adjusting the FM-EDF’s length and pump power. The analysis process presented here is very useful for the efficient design of FM-EDFAs from a practical point of view.
Magnetic Holography and Its Application to Data Storage
Authors: Nakamura Yuichi
Published: May 2021

The principle of magnetic holograms and its application to holographic memory are reviewed. A magnetic hologram was recorded through a thermomagnetic recording as a difference in magnetization direction and reconstructed with the magneto-optical effect. To achieve a bright reconstruction image, it is important to record deep magnetic fringes on the materials with large Faraday rotation coefficients. This technique was applied to the holographic memory using transparent magnetic garnets as a recording material. The first reconstruction image was dark and noisy, but improvements in the recording conditions resulted in error-free recording and reconstruction of the magnetic hologram. To form deep magnetic fringes, insertion of heat dissipation (HD) layers into recording layer was proposed. It was found that this HD multilayer medium showed diffraction efficiency higher than that of a single layer medium, and error-free recording and reconstruction were also achieved, using magnetic assisted recording. These results suggest that HD multilayer media have potential applications in recording media of magnetic holographic data storage. In future, a high recording density technique, such as multiple recording, should be developed.
Mechanical Performance and Dimensional Stability of Bamboo Fiber-Based Composite
Authors: Zhang Yahui , Yu Wenji , Kim Namhun , Qi Yue
Published: May 2021

The bamboo fiber-based composite (BFBC) has high-performce in terms of mechanical properties and dimensional stability. In this study, BFBCs were prepared with different hot-pressing temperatures (150 °C, 160 °C, 170 °C, 180 °C, 190 °C, and 200 °C) and designed with different densities (1.05 g/cm3, 1.10 g/cm3, 1.15 g/cm3 and 1.20 g/cm3), and their selected properties were evaluated. Temperature affected BFBC performance, which, with a general increase in temperature, showed a decrement in mechanical properties and an improvement in dimensional stability. Holocellulose content significantly decreased, and the color of BFBC became darker with the increasing of the press temperature. As the density of BFBC increased, the modulus of elasticity (MOE) significantly increased from 23.09 GPa to 27.01 GPa with the increase in temperature. The thickness swelling ratio (TSR), width swelling ratio (WSR) and water absorption ratio (WAR) declined by more than 30% with the increase in density. Overall, the results of this study provide a theoretical basis and a source of technical support to promote the design, application, and popularization of BFBC in different fields.
Virtual Approach to the Comparative Analysis of Biomaterials Used in Endodontic Treatment
Authors: Dobrzańska Joanna , Dobrzański Lech B. , Gołombek Klaudiusz , Dobrzański Leszek A. , Dobrzańska-Danikiewicz Anna D.
Published: May 2021

The importance of endodontics is presented within our own concept of Dentistry Sustainable Development (DSD) consisting of three inseparable elements; i.e., Advanced Interventionist Dentistry 4.0 (AID 4.0), Global Dental Prevention (GDP), and the Dentistry Safety System (DSS) as a polemic, with the hypothesis of the need to abandon interventionist dentistry in favour of the domination of dental prevention. In view of the numerous systemic complications of caries that affect 3−5 billion people globally, endodontic treatment effectively counteracts them. Regardless of this, the prevention of oral diseases should be developed very widely, and in many countries dental care should reach the poorest sections of society. The materials and methods of clinical management in endodontic procedures are characterized. The progress in the field of filling materials and techniques for the development and obturation of root canals is presented. The endodontics market is forecast to reach USD 2.1 billion in 2026, with a CAGR of 4.1%. The most widely used and recognized material for filling root canals is gutta-percha, recognized as the “gold standard”. An alternative is a synthetic thermoplastic filler material based on polyester materials, known mainly under the trade name Resilon. There are still sceptical opinions about the need to replace gutta-percha with this synthetic material, and many dentists still believe that this material cannot compete with gutta-percha. The results of studies carried out so far do not allow for the formulation of a substantively and ethically unambiguous view that gutta-percha should be replaced with another material. There is still insufficient clinical evidence to formulate firm opinions in this regard. In essence, materials and technologies used in endodontics do not differ from other groups of materials, which justifies using material engineering methodology for their research. Therefore, a detailed methodological approach is presented to objectify the assessment of endodontic treatment. Theoretical analysis was carried out using the methods of procedural benchmarking and comparative analysis with the use of contextual matrices to virtually optimize the selection of materials, techniques for the development and obturation of root canals, and methods for assessing the effectiveness of filling, which methods are usually used, e.g., in management science, and especially in foresight research as part of knowledge management. The results of these analyses are presented in the form of appropriate context matrices. The full usefulness of the research on the effectiveness and tightness of root canal filling using scanning electron microscopy is indicated. The analysis results are a practical application of the so-called “digital twins” approach concerning the virtual comparative analysis of biomaterials used in endodontic treatment.
A Systematic Evaluation of Semispecific Peptide Search Parameter Enables Identification of Previously Undescribed N-Terminal Peptides and Conserved Proteolytic Processing in Cancer Cell Lines
Authors: Fahrner Matthias , Kook Lucas , Fröhlich Klemens , Biniossek Martin L. , Schilling Oliver
Published: May 2021

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the most commonly used technique in explorative proteomic research. A variety of open-source tools for peptide-spectrum matching have become available. Most analyses of explorative MS data are performed using conventional settings, such as fully specific enzymatic constraints. Here we evaluated the impact of the fragment mass tolerance in combination with the enzymatic constraints on the performance of three search engines. Three open-source search engines (Myrimatch, X! Tandem, and MSGF+) were evaluated concerning the suitability in semi- and unspecific searches as well as the importance of accurate fragment mass spectra in non-specific peptide searches. We then performed a semispecific reanalysis of the published NCI-60 deep proteome data applying the most suited parameters. Semi- and unspecific LC-MS/MS data analyses particularly benefit from accurate fragment mass spectra while this effect is less pronounced for conventional, fully specific peptide-spectrum matching. Search speed differed notably between the three search engines for semi- and non-specific peptide-spectrum matching. Semispecific reanalysis of NCI-60 proteome data revealed hundreds of previously undescribed N-terminal peptides, including cases of proteolytic processing or likely alternative translation start sites, some of which were ubiquitously present in all cell lines of the reanalyzed panel. Highly accurate MS2 fragment data in combination with modern open-source search algorithms enable the confident identification of semispecific peptides from large proteomic datasets. The identification of previously undescribed N-terminal peptides in published studies highlights the potential of future reanalysis and data mining in proteomic datasets.
Conceptual scenarios for development of ground infrastructure for receiving mission payload data from a perspective Earth remote sensing satellite constellation
Authors: ERESHKO Maksim V. , BORISOV Andrey V.
Published: May 2021

The paper addresses the problem of cooperative development of ground space infrastructure and orbital constellation of Earth remote sensing spacecraft (ERS). In view of the considerable number of elements in space and ground segments of a heterogenous space ERS system, a mechanism is required for developing its concepts involving acquiring updated inputs for determining measures to optimize the ERS ground segment configuration geography-wise and outfit receiving systems for receiving the mission payload data from high-performance ERS spacecraft.
The paper describes trends in the development of equipment and technologies for transmitting ERS mission payload data, in particular, the current status of the high data rate optical backbone network in order to determine possible locations for ERS Ground Segment elements. It introduces indicators which provide system-level characterization of the capabilities for a distributed network of data receiving stations. Based on the obtained data, system-level patterns were determined in the development of the ground segment for receiving the ERS mission payload data depending on the state of the ERS orbital constellation, driving further development of growth strategy for the ERS ground space infrastructure.
Key words: Earth remote sensing, concept, mission payload data, receiving system, data reception station.
Ingeniería de Software aplicada al método global de análisis estructural para el aprendizaje del Español, Tének e Inglés en educación básica
Authors: IZAGUIRRE-CÁRDENAS Nelly Rosina , GARCIA-CHI Rosa Imelda , HERNANDEZ María Antonieta , EGUIA-ALVAREZ Arturo
Published: May 2021

The global method of structural analysis is characterized in that from the first moment the information units with a complete meaning are presented to the child. The global method is to apply to the teaching of reading and writing the same process that is followed in children to teach them to speak. The child has a visual memory, recognizes words, sentences and phrases, with this, establishes relationships between words and discovers the identical elements in the image of two different words. The writtenword is the drawing of and image that evokes each idea. The prototype model of software engineering when applying the analysis technique, determines the functional requirements of the global method and transforms it into a software product for teaching Spanish, Tenek and English in first grade primary school children. the region of Ciudad Valles, San Luis Potosí. The prototype methodology has the following stages: communication, rapid plan, modeling, design, prototype construction and development. The use of technology combined with the global teaching method will achieve in children the meaningful and constructive learning of their mother tongue (tének), the Spanish language and a foreign language.
Types and frequency of body postures and dental malocclusions
Authors: Capetillo-Hernández Guadalupe Rosalía , Tiburcio-Morteo Leticia , Ochoa-Martínez Rosa Elena , Torres-Capetillo Evelyn Guadalupe
Published: May 2021

The jaw is articulated with the skull through the temporomandibular joint. And the skull, in turn articulates with the spine (upper cervical). Important studies establish that up to 30-40 % of back pain can be caused or aggravated by dental malocclusion. Objective. To establish the types and frequency of body postures and dental malocclusions in the patients of the School of Dentistry in the period August-December 2019. Methodology. Transversal, descriptive and observational study. The sample was made up of a total of 50 patients between the ages of 19 and 70 who attended the Admission Clinic of the School of Dentistry. To which were carried out: verification of molar class, verification of midline deviation, verification of posterior crossbite, external lateral palpation of the TMJ, extraoral photographs, analysis of photographs. Contribution. It was found that there is a high frequency of one type of body posture and Angle Class I malocclusions, in patients from the School of Dentistry. In relation to malocclusions, Angle Class I predominated, as well as flattened posture, in Class II military posture and in Class III both flattened and military posture.
Satisfaction study of the teaching-learning process of students close to graduating from the Bachelor of Dental surgeon
Authors: Moreno-Marin Flora , Roesch-Ramos Laura , Mora-Sánchez Aura Leonora , Mantilla-Ruiz Manuel
Published: May 2021

The growing technological innovations, the claim of society that demands increasingly efficient services and the strong competition between educational institutions, forces them to offer increasingly better options especially in the field of health; In this context, the Universidad Veracruzana has assumed the task of implementing strategies to carry out an exhaustive analysis of the satisfaction of the students who are about to graduate from the Bachelor of Dental Surgeon. Objective: To know the level of satisfaction of students with respect to their Bachelor of Dental Surgeon upon graduation. Methodology: The Student Satisfaction Questionnaire was carried out with eight chapters; it consists of 11 dimensions and 104 items. The instrument used was designed based on the specifications of the National Association of Universities and Institutions of Higher Education ANUIES and was adapted to the information needs about students close to graduation, the respondents were kept anonymous to avoid bias. The students close to graduating from the Bachelor of Dental Surgeon at the UV are 31% satisfied, 54% between satisfied, quiet and very satisfied; for the poorly satisfied and dissatisfied indicators, only 12% was counted. Contribution: The educational program is socially relevant.
Sistema de acciones para la implementación del Emprendimiento aprovechando los trabajos académicos y trabajando en asociación entre diferentes carreras para además propiciar la multidisciplinaridad desde la formación profesional desde el aula
Authors: Hernández Tinoco Araceli , Cervantes-Guzmán Jovanna Nathalie , Reyes-Rodríguez Mónica Araceli
Published: May 2021

The University of Guadalajara is the second largest university in the country. The current reality demands of young people are to be prepared and to be able to apply the knowledge, therefore they would generate experience during their training. In the so-called Synergy project, the schoolar work is associated by the competencies of the students of two careers and two different thematic university centers, to promote multidisciplinary work, that relate, that know the skills and profiles of their counterpart and to propose a continuation, at the end of the semester, as a team, continue with the project until business with the support of the incubators of the Network.Food Science students create a food, characterize it and validate it, lend it to their marketing career partner to develop their business plan. The process is documented. Students in both careers liked the experience and believe what they lived valuable. There were better apprenticeships and new knowledge including the opportunity to live together and know the potential of their business projects. They applied knowledge and generated experience that they would not otherwise have had. At least half of the participants said they will continue the project in the incubator extracurricularly with institutional support. It will continue in the documentation until successful cases are obtained that will be used from tests and witnesses to the potential of the results of the synergy.
Socially responsible practices and workplace harassment, in a municipality as a political administrative organism
Authors: Pérez-Bravo Julia
Published: May 2021

Corporative social responsability, in recommendations or international guidelines, sets forth in the section of labor standards respect and care for the integrity of workers as an interested party within an organization. Workplace harassment in organizations harms workers morally, psychologically and physically.It is undeniable that in plenty of organizations workers are either misstread or harassed when they are either no longer requiered in said organization or are new entrants or there is some rivalry in between. Due to the aforementioned, it was pertinent to investigate the existence of these variables in the government of the Municipality of San Juan del Río, Querétaro, as an administrative political body, in the 2015-2018 administration, with the aim of knowing the practices in labor matters wich uses dependency, as a socially responsible body. The problem was analyzed through a quantitative approach with descriptive scope using the types of documentary and field research, using the case study of the Municipal Culture and Tourism Directorate, with the hypothetical deductive method and nor experimental design. The results derived from the research instruments show that the agency has good labor practices in a percentage of 40%, in the same way, they show that the existence of workplace harassment or abuse is low, since 25% of the dependency workers were surveyed and harassment practices were found in 16.66%.
The Role of Soluble Molecules CD25, CD38, and CD95 in the Development
of Immunosuppression in Cytomegalovirus Infection
Authors: Novikov VV , Kravchenko GA , Sobchak DM , Novikov DV , Shumilova SV
Published: May 2021

Introduction: Cytomegalovirus (CMV) infection is a common beta-herpesvirus infection widely spread in the human population. The proportion of infected population increases with age and approaches 100 % in elderly people. The infection is usually latent but is capable of reactivation when immunosuppression develops. The mechanisms of reactivation are not fully understood. The objective of our study was to evaluate the role of soluble molecules CD25, CD38, CD95 in the development of immunosuppression in CMV infection. Materials and methods: We used 18 serum samples from cases of CMV disease in the stage of reactivation, all confirmed by clinical and laboratory data. The patients received treatment in Nizhny Novgorod Infectious Disease Hospital No. 2. The serum content of the total and oligomeric soluble molecules CD25, CD38, and CD95 was identified by ELISA using monoclonal and polyclonal antibodies against human peripheral blood mononuclear cell proteins. The results were recorded spectrophotometrically and evaluated by converting optical density units to conventional units (U/mL). Results: We established an increase in the serum content of total and oligomeric fractions of soluble molecules CD25, CD38, and CD95 in the cases of CMV disease. While the serum content of the total and oligomeric fractions of molecules CD25 and CD38 increased equally, the oligomeric fraction of molecules СD95 demonstrated a more pronounced increase compared to the total fraction of these molecules. Our findings suggest the immune response suppression mechanism associated with initiation of apoptosis of effector T lymphocytes involving oligomeric form of molecules CD95. Conclusion: Changes in the content, structural and functional state of soluble differentiating molecules CD25, CD38, and CD95 indicate their involvement in immunosuppression mechanisms in patients with CMV infection.
Assets Growth, Earnings Persistence, Investment Opportunity Setand Earnings Management on Dividend Policy and Firm Value (Study at Bank Companies in Indonesia)
Authors: Indrayati  , Rachmat Basuki , Slamet
Published: May 2021

The purpose of this study was to test the effect empirically the influence of growth and earnings management on dividend payment policies and company value in as many as 40 banking companies listed on the Indonesian stock exchange in 2015-2019. The research method is explanatory research with secondary data, based on documentation data, data processing using the Structural Equation Model test. The results showed that asset growth had a negative and insignificant effect on dividends, persistence had no significant negative effect on dividends, investment opportunity set had a significant positive effect on dividends, earning management had a positive and insignificant effect on dividends, asset growth had no significant negative effect on the value company, dividends had a significant positive effect on firm value. Persistence has no significant positive effect on firm value. Investment opportunity set has a positive and insignificant effect on firm value, and earning management had a significant positive effect on firm value.
The Effects of ASEAN-China Free Trade Agreement on Bilateral Trades
Authors: Wong Colin Koh-King , Liew Venus Khim-Sen , Arip Mohammad Affendy
Published: May 2021

This article adopts the augmented versions of the Gravity Model to examine the effects of the signing of the ASEAN-China Free Trade Agreement (ACFTA) on the bilateral aggregate trades. Specifically, ACFTA dummy variables are incorporated in the basic model is to estimate the direction and magnitude of the ACFTA effects. A total of 79 trading partners of ASEAN member countries plus China were examined in this article. The study finds that the Gross Domestic Product, population, natural endowment, distance, and common language are the main determining factors of the bilateral trade for ASEAN member countries and their trading partners. Estimated results from this Augmented Gravity Model showed that ACFTA had increased the bilateral aggregate trades not only between intra-bloc member countries but also intra-bloc and extra-bloc countries. With this positive finding, ASEAN and China could consider expanding their free trade area to a broader regional perspective, enhancing economic growth and reducing regional inequality.
ANALISIS KINERJA PEGAWAI PADA DINAS PENANAMAN MODAL DAN PELAYANAN TERPADU SATU PINTU KOTA PEKANBARU (Studi dalam pelaksanaan pelayanan izin mendirikan bangunan)
Authors: Fernando Trio , Saeri H M , Albintani Munchid
Published: May 2021

Abstract (English)Good service cannot be separated from the role of service providers, namely government officials. The implementation of main duties and functions as government officials in providing good public services to the community is required to have adequate resources, the attitude of government officials which has an impact on the quality of services provided to the community who use services. The purpose of this study was to determine and analyze the performance of employees at the Pekanbaru City Investment and One Stop Integrated Service Service through a study on the implementation of building permit services with a focus on the performance of employees in realizing good service to the community. The research method used is qualitative and the data collection technique used in this research is descriptive qualitative. The results of this study indicate that the quality of employees is still not good, including there are some employees who are not in their place, while the community comes for their respective service needs, in other words, employees are not disciplined. There are inaccuracies in completing some tasks, as the researchers saw in field observations to obtain building permits and there is still a selective culture in its management.Abstrak (Indonesia)Pelayanan yang baik tidak lepas dari peran penyedia jasa yaitu aparatur pemerintah. Pelaksanaan tugas pokok dan fungsi sebagai aparatur pemerintah dalam memberikan pelayanan publik yang baik kepada masyarakat dituntut memiliki sumber daya yang memadai, sikap aparatur pemerintah yang berdampak pada kualitas pelayanan yang diberikan kepada masyarakat pengguna jasa. Tujuan penelitian ini adalah untuk mengetahui  dan menganalisis KInerja Pegawai Pada Dinas Penanaman Modal Dan Pelayanan Terpadu Satu Pintu Kota Pekanbaru melalui studi pelaksanaan pelayanan izin mendirikan bangunan dengan fokus kajian pada kinerja karyawan pegawai dalam mewujudkan pelayanan yang baik kepada masyarakat. Metode penelitian yang digunakan adalah kualitatif dan teknik pengumpulan data yang digunakan dalam penelitian ini adalah deskriptif kualitatif. Hasil penelitian ini menunjukkan bahwa kualitas pegawai masih kurang baik, diantaranya terdapat beberapa pegawai yang tidak pada tempatnya sedangkan masyarakat datang untuk kebutuhan pelayanannya masing-masing, dengan kata lain pegawai tidak disiplin. Terdapat ketidaktepatan dalam penyelesaian beberapa tugas, seperti yang peneliti lihat pada observasi lapangan untuk mendapatkan izin mendirikan bangunan dan masih adanya budaya selektif dalam pengelolaannya.