bluuebunny/crossref_metadata_2025 huggingface dataset:
The evolutionary acquisition and mode of functions of promoter-associated non-coding RNAs (pancRNAs) for mammalian development
Authors: An Boyang , Kameda Tomonori , Imamura Takuya
Published: July 2021

Increasing evidence has shown that many long non-coding RNAs (lncRNAs) are involved in gene regulation in a variety of ways such as transcriptional, post-transcriptional and epigenetic regulation. Promoter-associated non-coding RNAs (pancRNAs), which are categorized into the most abundant single-copy lncRNA biotype, play vital regulatory roles in finely tuning cellular specification at the epigenomic level. In short, pancRNAs can directly or indirectly regulate downstream genes to participate in the development of organisms in a cell-specific manner. In this review, we will introduce the evolutionarily acquired characteristics of pancRNAs as determined by comparative epigenomics and elaborate on the research progress on pancRNA-involving processes in mammalian embryonic development, including neural differentiation.
3D bioprinting: novel approaches for engineering complex human tissue equivalents and drug testing
Authors: Hagenbuchner Judith , Nothdurfter Daniel , Ausserlechner Michael J.
Published: July 2021

Conventional approaches in drug development involve testing on 2D-cultured mammalian cells, followed by experiments in rodents. Although this is the common strategy, it has significant drawbacks: in 2D cell culture with human cells, the cultivation at normoxic conditions on a plastic or glass surface is an artificial situation that significantly changes energy metabolism, shape and intracellular signaling, which in turn directly affects drug response. On the other hand, rodents as the most frequently used animal models have evolutionarily separated from primates about 100 million years ago, with significant differences in physiology, which frequently leads to results not reproducible in humans. As an alternative, spheroid technology and micro-organoids have evolved in the last decade to provide 3D context for cells similar to native tissue. However, organoids used for drug testing are usually just in the 50–100 micrometers range and thereby too small to mimic micro-environmental tissue conditions such as limited nutrient and oxygen availability. An attractive alternative offers 3D bioprinting as this allows fabrication of human tissue equivalents from scratch with hollow structures for perfusion and strict spatiotemporal control over the deposition of cells and extracellular matrix proteins. Thereby, tissue surrogates with defined geometry are fabricated that offer unique opportunities in exploring cellular cross-talk, mechanobiology and morphogenesis. These tissue-equivalents are also very attractive tools in drug testing, as bioprinting enables standardized production, parallelization, and application-tailored design of human tissue, of human disease models and patient-specific tissue avatars. This review, therefore, summarizes recent advances in 3D bioprinting technology and its application for drug screening.
Gamma-ray bursts as probes of high-redshift Lyman-αemitters and radiative transfer models
Authors: Vielfaure J.-B. , Vergani S. D. , Gronke M. , Japelj J. , Palmerio J. T. , Fynbo J. P. U. , Malesani D. B. , Milvang-Jensen B. , Salvaterra R. , Tanvir N. R.
Published: July 2021

Aims.We present the updated census and statistics of Lyman-αemitting long gamma-ray burst host galaxies (LAE-LGRBs). We investigate the properties of a subsample of LAE-LGRBs and test the shell model that is commonly used to fit Lyman-α(Lyα) emission line spectra.

Methods.We considered all LGRB host galaxies with relevant publicly available information. We defined a golden sample of four LAE-LGRBs (GRBs 011211, 021004, 060926, and 070110) with afterglow and host galaxy observations allowing us to constrain the shell modeling of the Lyαline.

Results.The census results in 29 detected LAE-LGRBs. We present 5 new Lyαemission detections in host-galaxy spectra and the corresponding unpublished VLT/X-shooter data (GRBs 060926, 070110, 081121, 081222, and 100424A). From the comparison of the statistics and properties of LAE-LGRBs to those of LAE samples in the literature, we find evidence of Lyαsuppression in dusty systems. The fraction of LAE-LGRBs in the overall LGRB hosts is lower than that found for Lyman-break galaxy (LBG) samples at similar redshift range. This result can arise because the selection criteria of the parent samples are different and the spectral observations of LGRB samples are shallower than those of LBG. However, we find that LAE-LGRBs are representative of Lyαemission from the bulk of UV-selected galaxies atz ∼ 2. We find that the golden sample of LAE-LGRBs we studied consists of complex systems characterized by multiple emission blobs and by signs of possible galaxy interactions. The fitting procedure recovers the HIcolumn densities (NHI) measured from the afterglow spectra and the other properties described by the shell-model parameters in the two low-NHIcases, but it fails to do this in the other two cases with highNHI. The afterglows of most LGRBs and LAE-LGRBs show log(NHI/cm−2) > 20.3, implying that statistically, the bulk of Lyαphotons that is expected to be produced by massive stars in the star-forming region hosting the GRB will be surrounded by these opaque lines of sight. We therefore interpret our results in the context of more sophisticated models and of different dominant Lyα-emitting regions. We also compare LAE-LGRBs to LAE Lyman continuum (LyC) leakers in the literature in terms of the properties that are identified as possible indirect indicators of LyC leakage. We find that only one LGRB (GRB 021004) would likely be a strong LyC leaker and discuss the validity of these indicators at high redshift. While our work shows that LGRBs are useful tools for probing LAEs and radiative transfer models, larger statistics are required to strengthen our findings.
Which molecule traces what: Chemical diagnostics of protostellar sources
Authors: Tychoniec Łukasz , van Dishoeck Ewine F. , van ’t Hoff Merel L. R. , van Gelder Martijn L. , Tabone Benoît , Chen Yuan , Harsono Daniel , Hull Charles L. H. , Hogerheijde Michiel R. , Murillo Nadia M. , Tobin John J.
Published: July 2021

Context. The physical and chemical conditions in Class 0/I protostars are fundamental in unlocking the protostellar accretion process and its impact on planet formation.

Aims. The aim is to determine which physical components are traced by different molecules at subarcsecond scales (<100–400 au).

Methods. We used a suite of Atacama Large Millimeter/submillimeter Array (ALMA) datasets in band 6 (1 mm), band 5 (1.8 mm), and band 3 (3 mm) at spatial resolutions 0.″5–3″ for 16 protostellar sources. For a subset of sources, Atacama Compact Array (ACA) data at band 6 with a spatial resolution of 6″ were added. The availability of low- and high-excitation lines and data on small and larger scales, is important to understand the full picture.

Results. The protostellar envelope is well traced by C18O, DCO+, and N2D+, which stems from the freeze-out of CO governing the chemistry at envelope scales. Molecular outflows are seen in classical shock tracers such as SiO and SO, but ice-mantle products such as CH3OH and HNCO that are released with the shock are also observed. The molecular jet is a key component of the system. It is only present at the very early stages, and it is prominent not only in SiO and SO, but occasionally also in H2CO. The cavity walls show tracers of UV-irradiation such as C2H, c-C3H2 and CN. In addition to showing emission from complex organic molecules (COMs), the hot inner envelope also presents compact emission from small molecules such as H2S, SO, OCS, and H13CN, which most likely are related to ice sublimation and high-temperature chemistry.

Conclusions. Subarcsecond millimeter-wave observations allow us to identify these (simple) molecules that best trace each of the physical components of a protostellar system. COMs are found both in the hot inner envelope (high-excitation lines) and in the outflows (lower-excitation lines) with comparable abundances. COMs can coexist with hydrocarbons in the same protostellar sources, but they trace different components. In the near future, mid-infrared observations with JWST–MIRI will provide complementary information about the hottest gas and the ice-mantle content, at unprecedented sensitivity and at resolutions comparable to ALMA for the same sources.
A multiwavelength analysis of the spiral arms in the protoplanetary disk around WaOph 6
Authors: Brown-Sevilla S. B. , Keppler M. , Barraza-Alfaro M. , Melon Fuksman J. D. , Kurtovic N. , Pinilla P. , Feldt M. , Brandner W. , Ginski C. , Henning Th. , Klahr H. , Asensio-Torres R. , Cantalloube F. , Garufi A. , van Holstein R. G. , Langlois M. , Ménard F. , Rickman E. , Benisty M. , Chauvin G. , Zurlo A. , Weber P. , Pavlov A. , Ramos J. , Rochat S. , Roelfsema R.
Published: July 2021

Context. In recent years, protoplanetary disks with spiral structures have been detected in scattered light, millimeter continuum, and CO gas emission. The mechanisms causing these structures are still under debate. A popular scenario to drive the spiral arms is the one of a planet perturbing the material in the disk. However, if the disk is massive, gravitational instability isusually the favored explanation. Multiwavelength studies could be helpful to distinguish between the two scenarios. So far, only a handful of disks with spiral arms have been observed in both scattered light and millimeter continuum.

Aims. We aim to perform an in-depth characterization of the protoplanetary disk morphology around WaOph 6 analyzing data obtained at different wavelengths, as well as to investigate the origin of the spiral features in the disk.

Methods. We present the first near-infrared polarimetric observations of WaOph 6 obtained with SPHERE at the VLT and compare them to archival millimeter continuum ALMA observations. We traced the spiral features in both data sets and estimated the respective pitch angles. We discuss the different scenarios that can give rise to the spiral arms in WaOph 6. We tested the planetary perturber hypothesis by performing hydrodynamical and radiative transfer simulations to compare them with scattered light and millimeter continuum observations.

Results. We confirm that the spiral structure is present in our polarized scattered light H-band observationsof WaOph 6, making it the youngest disk with spiral arms detected at these wavelengths. From the comparison to the millimeter ALMA-DSHARP observations, we confirm that the disk is flared. We explore the possibility of a massive planetary perturber driving the spiral arms by running hydrodynamical and radiative transfer simulations, and we find that a planet of minimum 10 MJup outside of the observed spiral structure is able to drive spiral arms that resemble the ones in the observations. We derive detection limits from our SPHERE observations and get estimates of the planet’s contrast from different evolutionary models.

Conclusions. Up to now, no spiral arms had been observed in scattered light in disks around K and/or M stars with ages <1 Myr. Future observations of WaOph 6 could allow us to test theoretical predictions for planet evolutionary models, as well as give us more insightinto the mechanisms driving the spiral arms.
Technological innovations and the effect of ‘dualism’
Authors: Sukharev Oleg
Published: July 2021

The purpose of the research is to consider the effect of technological dualism for the Russian economy with an empirical demonstration that this effect has a different content. The research methodology consists of the neo-Schumpeterian theory of technological change, structural analysis, and empirical estimates that allow one to identify the characteristics of technological dynamics. The result of this research was a demonstration of the deviation from the classical effect of technological dualism of the Russian economy, which is caused by the existing structural and institutional characteristics of the functioning of activities various types. The main conclusion is that the classical recipes for stimulating technological innovation in the presence of the pseudo-effect of technological dualism will not become working tools with high action. We need systemic and institutional transformations that affect the incentives for technological renewal and the deployment of markets that accept products that embody the results of technological improvement and development. Thus, replacing the strategy of local technological innovations with a strategy of comprehensive incentives and large-scale technological innovations that improve the social parameters of life is an urgent task for the Russian economy.
Management of generation Z staff in the digital economy
Authors: Kraidenkov Yaroslav , Sviridova Lyudmila
Published: July 2021

This article is a continuation, which examines the difference between generations and their common qualities for forming a successful team, but with a focus on generation Z. Materials on the comparison of generations X and Y are published in the journal Vestnik PNIPUV in the article Team building in the digital economy [1]. This article presents an analysis of the current state of generations X and Y with the relevant research points and recommendations for team building of personnel of generations X and Y. In 2019, at the time of the publication of the first part of the article, our team started a project to conduct their research in the part of Generation Z. Participants in this study were young people born between 2003 and 2005. The study ended in January 2021. A total of 1,14 people were interviewed during the period: high school students, university students, and first-and second-year students of universities in the cities of Moscow, Samara, Nizhny Novgorod, Novokuibyshevsk, Syzran.
How to manage public opinion: theoretical and applied tasks of the sociology of public opinion
Authors: Burko Viktor
Published: July 2021

The article deals with theoretical and applied problems that exist today in the field of interaction between government bodies and public opinion. At the end of the last century, the existence of the sociology of public opinion was questioned by many Russian sociologists, who considered public opinion to be a kind of state of public consciousness that did not have specific scientific categories. Such a theoretical paradigm made it difficult to find ways to effectively interact with public opinion. At the same time, many problems of the sociology of public opinion about which the many authors spoke at one time still exist today. In particular, the problem of determining the role and place of the subject of public opinion remains important, especially in the field of interaction between power, management structures and the population. Today, in the era of digital communication, the importance of an innovative approach to building a representative sample is growing, when surveys are increasingly conducted online and the results of such a survey cannot always serve as the basis for making effective management decisions. And, finally, there remains an important problem of improving the professionalism of public opinion researchers (pollsters) working in the fields of both political and industrial marketing. The author makes an attempt to draw the attention of management specialists to the need to take these problems into account in cooperation with specialists representing the field of sociology of public opinion.
Monetary and informational form of capital as the basis of investment support for the inter-phase transition to an innovative economy
Authors: Butorina Oksana , Starodumova Yulia
Published: July 2021

Within the framework of the identified predominant processes that form the uniqueness of inter-phase transitions, the article highlights the accumulating processes of system transformation. At the same time, within the framework of the transition from the neo-industrial to the digital economy, informatization as a conjunctural process, based on the mass introduction of digital technologies, contributes to the formation of the monetary and information form of capital. Based on the analysis of the definitions of monetary and informational forms of capital, two approaches can be identified. The first of them is narrow, from his point of view, the MIFC is investment resources in real assets through digital and IT technologies. The second approach is broad, it allows us to interpret MIFC as an independent form of capital associated with the self-increasing cost of investments in the development of information and labor resources to create new high-tech products that can increase surplus value at each intra-phase transition of the post-industrial megacycle.
Modern city: the system of local government and support of small and medium-sized businesses
Authors: Buchwald Evgeniy
Published: July 2021

The article analyzes issues related to the impact of various reforms in the sphere of Russian self-government on the development of Russian cities, especially in the context of new territorial administration systems. As the initial premises of such reforms, we consider, first of all, the constitutional innovations of 2020, which in one way or another affected the economic and legal foundations of Russian local self-government, in particular, through the approval of a single institution of “public power” in the country. The concept of “public authority” is intended to embody the unity and interaction of state and municipal administration in solving the problems of socio-economic development of territories. Further, in the context of the development of cities and their management systems, the tasks of preparing new “Foundations...” of state policy in the field of local self-government are discussed. Emphasis is placed on the need to strengthen the role of municipal management structures in supporting small business forms. The importance of specifying the place and role of various types of municipalities in the practice of strategic planning is shown.
Theory of analysis of the innovative ecosystems development
Authors: Popov Evgeny , Simonova Victoria , Chelak Igor
Published: July 2021

The ecosystem approach makes a significant contribution to understanding the current transformations of socio-economic life. New end-to-end technologies have a high potential to minimize the transaction sector in order to focus on meeting the real needs of people and firms and forming economic, political, cultural, and value institutions for sustainable development and justice for all. It seems that the technological breakthroughs of recent years, as well as the reverse pandemic economic dynamics, provide ample opportunities for the spread of innovative ecosystems as a new form of coordination of production activities. The unique characteristics of ecosystems as predominantly self-organizing communities allow us to identify a number of conceptual approaches to the analysis of their development: network, system, digital, stakeholder, and transactional. The objectives of the article do not include their detailed presentation. We show the applicability of approaches for ecosystem analysis. Based on the description of the options and possibilities for the applicability of these approaches, we came to the conclusion that the nature of innovative ecosystems is dual. First, the latter allow us to model (structure, systematize) interorganizational, inter-firm relations in a new way, to identify ecosystem features of communities, industrial and regional complexes. Second, ecosystems need to be recognized as a new form of transactional coordination of economic activity. They are alternatives to institutions such as the firm, the market, and hybrid forms. The increment of scientific knowledge consists in the implementation of the main goal of the study -the systematization of methods for analyzing the development of innovative ecosystems based on the formation of ideas for ecosystem analysis of innovation management.
Social orientations as a factor in the accelerating differentiation of the information society
Authors: Ermakov Mikhail , Okonskaya Natalia , Stegniy Vasiliy
Published: July 2021

In this article, a sociological analysis of the “social orientations” category is presented as a methodological principle of separation of external (social attitudes) and internal (value orientations) incentives of communication. External incentives, drawing a person into technological dependence on the NBIC-technologies used, cause a break in humanitarian relations, hinder the development of self-identity, and lead to a decline in social differentiation. In opposite, human capital, as the main element of the novelty of production relations in the information age, enters into a deep hidden contradiction with the power of management and the alienation of the individual abilities and needs. Subjective factors, expressed by the human value orientations, in the conditions of new opportunities opened up by informatization and digitalization of all social institutions, receive global advantages for maintaining harmony and progress in the society development, despite the objective instability of irreconcilable contradictions between large social groups. For empirical identification of qualitatively new subjective factors of social differentiation multiplication, the author’s typology of personalities is used, which unites actors into typological groups distinguished by social orientations. Terminal type, distinguished by the dominance of terminal (ultimate semantic) values and motives in the personality structure; inert type, the core of the “information poor”; instrumental type, occupying an intermediate position. Primary and secondary research made it possible to predict new opportunities for using the institution of education, in addition to the objective potentials of society self-development in the case of multidirectional differentiation.
The recurrent approach to the study of innovative economic development
Authors: Butorina Oksana , Shishkina Irina
Published: July 2021

The recurrent approach is an integrated approach that combines existing studies of cyclic macroeconomic processes, taking into account the nature of their intercyclic and interphase dependencies. According to this approach, the innovative economy is a natural phase of depression (interphase transition from the neo-industrial economy to the information innovative economy) within the modern transformation cycle. Recognition of the significance of the depression phase allows us to assert that the innovative economy has a twofold nature; it intertwines the processes characteristic of the neo-industrial economy, and forms processes that ensure a “breakthrough” to the neo-economy. In other words, it is dependent on the neo-industrial processes, implying increased digitalization, and becomes the basis for the development of the neo-economy. Taking into account the objectivity of the twofold nature of the innovative economy, it can be argued that it is a special type of the economic system based on a continuous stream of innovations, constant technological improvement, production and export of high-tech products with high added value and technologies, determined by a combination of information, technological, investment, industrial, structural and social transformations.
Development strategies for small and medium-sized enterprises with limited investment resources
Authors: Gusakov Boris , Sotnikova Anna
Published: July 2021

The main source of investment resources for small and medium-sized enterprises is their own profit. The dynamic development of these enterprises is possible only with a strategic program aimed at implementing independent discrete measures. The following tasks are relevant: development of a set of program measures; optimization of measures; maintenance of the financial stability of the enterprise by adjusting development program indicators. The indicators are strategic guidelines for the development. The target functions of the effectiveness of strategic management are minimization of the period of implementation of the development program and the maximum asset growth rate. To assess the effectiveness of development, the following indicators developed by the authors can be used: the coefficient of innovation management, which characterizes the average geometric growth rate of assets attracted during the initial period; the index of innovation management, which characterizes the quality of management by comparing the average geometric growth rate of assets of the optimal and basic variants of the development program.
Managing budgetary openness of public services
Authors: Razinova Elena
Published: July 2021

The analysis of the aspects of information transparency of public finance in terms of public services (lists of public services, government assignments and information on subsidies for financial support of government assignments, cost standards for the provision of public services) at the federal and regional levels. Regulatory legal acts of the constituent entities of the Russian Federation, official websites of executive authorities and specialized federal resources for publishing budget data are considered. In accordance with the identified contradictions, the information objects published at the federal and regional levels were ranked according to the level of budgetary openness, and areas of improvement associated with increasing the level of accessibility and transparency of public finance data were identified.
Formation of conceptual foundations for modeling the organizational structures of agricultural entities based on multilevel cooperation
Authors: Pestrikov Sergey , Maltsev Dmitry , Gureeva Elena
Published: July 2021

The article presents an analysis of the organizational structures of cooperatives in the agricultural industry, offers conceptual approaches to modeling the organizational structures of agricultural formations in Russia, taking into account the specifics of the industry, using modern and innovative strategies for organizational changes. The creation of flexible multilevel systems of cooperation is substantiated, allowing, on the one hand, to consider the interests of both members of a single cooperative and a group of cooperatives that synergistically consolidate the available and attracted resources. An assessment of the importance of these principles for creating an effective cooperative structure is based on analyzing a survey of peasant farms in the Perm Territory. A promising organizational structure of multilevel cooperation has been developed.
Management-developing of an algorithm for the design decisions in the innovative activity of an organization
Authors: Polyakov Yuri , Savchenko Andrey , Savelyev Mikhail , Perevedentsev Denis , Koscheeva Anna
Published: July 2021

This article proposes a new algorithm for developing conceptual project decisions in terms of an organization or innovator’s response to changing consumer demands through the development and investment in innovations. The theoretical basis for choosing the type of an algorithm was elaborated by studying the available referencies relevant to present issues of the applicability of types of algorithms for developing management decisions. A multistage multicriteria algorithm (hereinafter referred to as MMA) was developed on the basis of studied algorithms. On developing the stages of the MMA, a set of thinking methods (analysis – synthesis, deduction – induction), a decomposition method, and logical methods were used. MMA is considered as a set of step-by-step sequential descriptions of local processes, formulations and solutions of management tasks, used decision methods and decision-making criteria. The SMART(ER) method was used for managerial tasks at each stage to be set. When solving a management problem, a set of methods was used including an expert method, a factor analysis, brainstorm and methods for calculating economic efficiency. For choosing solutions at each stage to be made, a set of criteria was used. They are the weight of the negative impact on the result of the activity, the yes/no method, the maximum effect, costs minimizing, risks. The schematic design was defined for MMA to be developed. The schematic design was considered as a method of modeling and a method of graphical-analytical displaying of the stages of the process.
Macroeconomic signs of an innovative economy by the case of Great Britain
Authors: Savelyev Mikhail , Kozyrev Mikhail , Savchenko Andrey , Koretsky Vladimir , Galiakhmetov Rail
Published: July 2021

By the case of the economic development of Great Britain, the hypothesis was verified that innovations at the macroeconomic level should accelerate economic growth and at the same time reduce development risks, stabilizing this growth, reducing its fluctuations under the influence of market factors. The economic development of Great Britain is investigated in 25 economic cycles for the period from 1830-2020. Economic development was investigated according to the parameters of economic growth and development risk in each of the considered cycles. Four types of economic development policy are theoretically described in terms of the dynamics of changes in growth and risk between the previous and subsequent cycles including progressive, regressive, aggressive and conservative. In relation to the identified periods of progressive development policy in Great Britain, the institutional innovations that led to this type of development were investigated. Among them was the great economic reform of the early Victorian era, the course of social or new liberalism and the popular budget before the First World War, the activities of the first Labor government immediately after this war, economic recovery after World War II in combination with the Marshall plan and nationalization, the era of the Conservatives and the politics of New Labor at the end of the 20th century. The study showed that the implementation of authentic national culture and institutions complementary to the existing authentic culture institutions of institutional innovations leads to a simultaneous decrease in the risk of development and acceleration of economic growth, which can be considered the most favorable policy of macroeconomic management of entrepreneurial activity in order to accelerate the application of technical and commercial innovations.
Development of a matrix method for the assessment of information and economic security of an industrial enterprise
Authors: Melnikova Anna , Mylnikova Elena , Moskvitina Irina , Nagibina Nadezhda
Published: July 2021

The article focuses on the problem of the assessment of the state of industrial enterprise’s economic and information security. The purpose of the research is to develop an scoring matrix for information and economic security of an industrial enterprise. The paper presents the necessary economic indicators and their normative values. It also presents the criteria for assessing information security, illustrates the developed matrix and defines development strategies for each element. More over, it describes the algorithm for the use of the matrix. The scientific novelty of the paper is in the development of a matrix that assesses both the economic activity and information of an industrial enterprise in order to determine the priority direction of the development. As a result of the work, the authors present a matrix of information and economic security of an industrial enterprise with individual development strategies for each element. The results of the study will be useful for industrial enterprises not only to analyze their activities, but also to determine the directions of further development.
High-potential human resource management in the place marketing system
Authors: Simonova Lyudmila , Zyryanova Anna
Published: July 2021

Serious competition for potentially valuable workers between the management teams of the regions is currently observed. The aim of the work is to form the concept of high-potential human resource management in the system of place marketing of the region (Tyumen region was taken as an example). In the “war for talents”, a region needs to compete for retaining and attracting primarily such target groups as youth and young families with children. Another significant target group is migrants -former residents of the region, who now live outside the region or country. It is this target group that is in the focus of the study, forming significant elements of the regional talent management as a system that are the ways of interaction between the talent management system and the external environment (region). The online survey, carried out for more than 100 ex-residents of Tyumen region, revealed the prospects of their participation in the regional economy and built the basis of the brand platform of Tyumen Region for this target audience. It is proposed to integrate such HR-marketing tools as EJM (Employee Journey Map), EX (Employee Experience), ERM (Employee Relationship Management) into the management system for this segment.
Business process model with “RandomForest” algorithm
Authors: Kukartsev Anatoly , Fedorova Alexandra , Danilchenko Yuriy , Lobkov Konstantin , Korepanova Evgeniia
Published: July 2021

Currently, the areas of application of machine learning are multifaceted: artificial intelligence, financial applications, bioinformatics, intellectual games, speech and text recognition, computer language processing, medical diagnostics, technical diagnostics, text search and rubrication. Machine learning is an area of scientific knowledge associated with learning-capable algorithms. The use of machine learning methods is explained by the fact that for most intelligent complex tasks (for example, speech recognition, etc.) it is almost impossible to develop an obvious algorithm for their solution. However, you can teach a computer to learn how to solve such problems. In our article, we propose a model based on the machine learning algorithm “RandomForest”, which allows one to recognize bots by HTTP sessions. The chosen algorithm provides many advantages: non-iterative learning; high quality of the resulting models (comparable to neural networks and ensembles of neural networks); a small number of adjustable parameters. It works well with missing data (retains good accuracy); internal assessment of the generalizability of the model; able to work with raw data without preprocessing. The algorithm was trained on a dataset of more than 5000 sessions. The prospects of this direction are obvious, since robotic traffic accounts for more than 40% of the total Internet traffic.
Evaluation of the effectiveness of leveraging capital of a telecommunication company
Authors: Martynova Tatyana , Antamoshkin Oleslav , Danilchenko Yuriy , Eremeev Dmitry , Vaitekunene Elena
Published: July 2021

Any company, and especially an actively developing one, constantly feels the need to attract financial resources. Debt capital plays an important role for companies as an additional means for expanding and carrying out economic activities. Accordingly, effective management of borrowed capital is economically beneficial for the company, and the wrong approach to the formation of borrowed sources of the company can adversely affect its financial condition. The object of research in this article was PJSC “MegaFon”. A characteristic feature of this industry is the increased competition due to the aggressive policies of both telecom operators and companies that have entered this market from related industries. In the study, the process of forming borrowed funds by the company is presented in the form of five consecutive stages. The approbation of the proposed research scheme, using the example of PJSC “MegaFon”, showed the ambiguity of the financial decisions made to attract borrowed capital. And the main recommendation is to attract borrowed funds only for the development of the company.
Manufacturing enterprise management concept focused on maximum customer engagement
Authors: Tynchenko Vadim , Kukartseva Oksana , Ogol Aygul , Yamshchikov Andrei , Bondarev Aleksandr
Published: July 2021

This article examines one of the main directions for improving the activities of structural units - lean production, which is widely practiced abroad, but in Russian conditions it is mainly used by large manufacturing companies focused on the foreign market. The article discusses the methodology for the implementation of lean manufacturing. Seven types of losses were given, as well as a complete sequence of actions to eliminate them. We learned a value stream map, types of streams and their composition according to various factors. We examined the tools in the Lean Manufacturing system for the implementation of this technique. Also, enterprise management systems based on push and pull systems were described, diagrams for them were given that show the essence of the operation of these systems. At the end of the work, conclusions were drawn about the way to improve the enterprise, such as “lean manufacturing”. The main objective of this article is to identify the essence and features of the research based on the principles of lean production in the structural unit of the research object.
The functional state of physically gifted preschoolers with high aerobic capacity
Authors: Krivolapchuk Igor A. , Chernova Mаria B. , Larionova Liudmila I. , Postavnev Vladimir M. , Kesel Sergey A.
Published: July 2021

The study aims to identify the features of the functional state of physically gifted children 5-6 years old with a high level of development of aerobic capacity under conditions of cognitive loads performed at different speeds. The authors used tests based on Anfimov’s letter tables as models of intense cognitive load. The examination was carried out at rest and while working at a comfortable speed and the maximal possible speed. Based on the results of the tasks, the speed and productivity of work, indicators of the psychophysiological cost of activity were calculated. Using the Luscher test, the level of situational anxiety was assessed and the coefficient of autonomic tone was determined. To diagnose the emotional state, the Lutoshkin technique was used. The tension of the systems of autonomous and central regulation of physiological functions was measured based on temporal analysis of the heart rhythm. Systolic and diastolic blood pressure, pulse and mean pressure, double product, Kerdo vegetative index, Myznikov index, and functional changes index were also calculated. A complex indicator of the development of aerobic capacity was found, taking into account the power, capacity, and efficiency of an aerobic source of energy supply to muscles. Based on the sigma scale, 7 gradations for assessing the development of aerobic abilities were identified, namely, very low, low, below average, average, above average, high, very high (above M + 2.0σ). The results obtained show that psychophysiological changes in the functional state during intense cognitive load in children aged 5-6 years largely depend on the development of aerobic capacity. It was found that physically gifted preschoolers with a high level of development of aerobic capacity were distinguished by optimally reduced activity during a calm wakeful state and less pronounced psychophysiological reactivity in conditions of intense cognitive load. They were characterized by increased efficiency of activity and its low psychophysiological cost in combination with increased adaptive potential of the organism.
Olympiad potential for identifying mathematical giftedness in elementary schoolers
Authors: Zubova S.P. , Lysogorova L.V. , Kochetova N.G. , Fedorova T.V.
Published: July 2021

The purpose of this article is to demonstrate the possibilities of identifying the mathematical giftedness in elementary schoolers with the help of Olympiad problems. For this, the authors clarify the concept of “mathematical giftedness”, show the relationship between the concepts of “mathematical giftedness” and “mathematical abilities”, and indicate the most significant abilities of elementary schoolers from the set of mathematical giftedness. The role of mathematical Olympiads in identifying mathematically gifted elementary schoolers is substantiated. This role consists in creating situations where the participants of the Olympiad are forced to make mental efforts to perform the following actions: analysis of a problem situation to identify essential relationships, modeling a new way of action to solve the proposed problem, combining available methods of action to apply in a new situation in limited time. The criteria for compiling Olympiad tasks for identifying mathematically gifted students are formulated, the most important of which is the clear focus of each task on demonstrating a mathematical ability of a certain type, as well as the selection of the mathematical content of the Olympiad problems strictly from the elementary course of mathematics. The problems of one Olympiad should be based on the content of different sections of the elementary mathematics course. The examples of the Olympiad problems based on the content of the elementary mathematics course are provided and the substantiation of their role in demonstrating the mathematical abilities of the Olympiad participant in solving them is given. The results of observing the educational achievements of students (during their entire stay at school) who showed mathematical abilities at the Olympiads are provided as well as the prospects and certain difficulties of further research on ways to solve the problem.
Formation of meta-subject components of ICT competence
Authors: Shutikova Margarita Ivanovna , Matveeva Valentina Aleksandrovna
Published: July 2021

The changes in education dictated by the 4th industrial revolution and the specifics of training future teachers in primary education associated with the multidimensionality of pedagogical activities give grounds for refining the structural and content model of ICT competence of future teachers in primary education. In the contemporary information society, establishing a holistic view of the unity of information processes is a prerequisite for educational process organization. The insufficient level of ICT competence in future teachers in primary education and the need to achieve meta-disciplinary results in education serve as a basis for the clarification and specification of the model of this concept. The authors propose an expansion of the invariant component composition of ICT competence with meta-subject components (the variable core of the competence): semiotic, technological, and integrative. Refining the structural and content model and identifying the methods and techniques that contribute to the formation of ICT competence in future teachers in primary education and allow reaching meta-subject results. One of the main instruments contributing to the formation of ICT competence is mathematical modeling based on the universal sign-symbol system and most suitable for designing computer models. The methodology based on the method of cross-curricular tasks allows achieving meta-subject results in the construction of the educational process of training future teachers in the field of primary education. Research demonstrates that enriching the educational process of future teachers in primary education with schematic, graphic, and geometric tools and the implementation of the method of cross-cutting tasks that serves as a leading means of teaching mathematics contribute to the emergence of a stable positive dynamic in the formation of information culture, particularly the meta-subject components of ICT competence of future teachers in the field of primary education.
Training teacher-tutors for developing giftedness in children during research
Authors: Zinovyeva Tatiana Ivanovna , Afanasyeva Zhanna Viktorovna , Bogdanova Antonina Vladimirovna , Leonovich Evgeniy Nikolaevich
Published: July 2021

The article deals with the issues of teacher training in the higher education system. The purpose of the study is to justify the possibility of forming a pedagogue’s readiness for tutor support of students’ research in the context of developing giftedness in children. The prerequisites for the study are the challenges of the rapidly changing society and the resulting focus of the education policy on nurturing professionals who are competitive in the labor market, increased interest of researchers and organizers of the higher education system in the search for ways to increase the training quality of specialists in every area of social life including the training of specialists in pedagogy. Scholarly achievements in the development of a teacher’s professionalism, tutor support in the education process, teaching research, and promotion of giftedness in children are also key factors in the study. The main research method is the method of theoretical analysis of scientific pedagogical and psychological-pedagogical literature. The authors have selected and explored a substantial set of sources in Russian and English published predominantly over the last five years in science-driven databases such as the Russian Science Citation Index, Web of Science, Scopus, and other peer-reviewed outlets. Results and novelty: the context of the recent developments in pedagogical science in the field of training professionals is adequate to the trends and goals of modern education – the inclusion of student teachers in the actual practice of tutor support of students, the organization of teaching research to schoolchildren, and the development of giftedness in children. The solution to these problems is ensured by streamlining the educational process at the university based on a universal model for developing the teacher’s professionalism, through the implementation of the reflexive and activity-based approach.
Study of Reproductive Toxicity of the Liposomal Photosensitizer
Lipophthalocyan
Authors: Konyaeva Olga , Kulbachevskaya Nataliya , Chaley Vera , Ermakova Nadezhda , Varaksa Pavel , Lantsova Anna , Nikolaeva Lyudmila , Orlova Olga , Rodionova Yuliya , Bunyatyan Natalia
Published: July 2021

Objective Study of embryotoxicity, teratogenicity and reproductive
toxicity of the new drug Lipophtalocyan in rats.

Material and Methods Studies were conducted on 210 non-inbred female rats
and 105 non-inbred male rats. The drug was administered daily via i. v.
injection for 48 days (males) and for 15 days (females) in 2 total doses
corresponding to the therapeutic dose (TD) for mice when converted to rats and
10 TD.

Results and Conclusion When mating with intact female rats, no changes in
sexual behavior were observed, but the index of the ability to fertilize and
conceive decreased when compared to the values of the control group by
35–40% (TD index=60%) and by
75–80% (10 TD index=20%). The index of the
ability to fertilize and conceive differed from the values of the control group
by 90% (TD index=5%) and by 15% (10 TD
index=80%). There were no differences in the indicator of
embryotoxicity and teratogenicity in intact and drug-treated female rats,
compared with the control group. Lipophtalocyan has a negative effect on the
male and female reproductive function in rats and has an embryotoxic effect
according to the index of the ability to fertilize and conceive, as well as the
indices of preimplantation and post-implantation fetal death. The drug does not
have a teratogenic effect, neither it affects the physical development of
offspring or the rate of maturation of sensory-motor reflexes during
feeding.