bluuebunny/crossref_metadata_2025 huggingface dataset:
Podcast de divulgação científica:
Authors: ABREU-TARDELLI LILIA
Published: February 2025

Este artigo objetiva, inicialmente, explicitar o processo de construção de um podcast para divulgar e combater a violência contra a mulher a partir e uma demanda da sociedade civil e, em seguida, a partir dos resultados da análise do episódio mais acessado no YouTube, evidenciar as características comuns do episódio com o modelo didático do 3MT (Abreu-Tardelli, 2021a), modelo no qual o podcast se baseou para ser construído. Tanto a análise do podcast quanto o modelo didático do 3MT aqui sintetizado pautaram-se no quadro de análise textual do interacionismo sociodiscursivo (Bronckart, 1999; 2006). Os resultados mostraram o uso da sequência explicativa, a presença de discurso teórico e interativo, assim como a presença de diferentes modalizações e vozes que trazem semelhanças com o 3MT. As diferenças também ocorrem, em parte devido ao fato de o podcast proposto ser editado e, com isso, possuir mais margem de uso de estratégias linguísticas e multimodais. Com isso, defendemos a ideia de que o podcast de divulgação científica pode ser considerado um gênero textual e midiático que pode contribuir para a divulgação científica assim como no estreitamento da relação da sociedade com a universidade.
métrica das citações na classificação de indicadores de artigos científicos em direito:
Authors: Dieguez Tiago , Alves Assis Juliana , Komesu Fabiana
Published: February 2025

No contexto da escrita acadêmico-científica, a referência aos trabalhos de outros pesquisadores é uma prática comum, que responde a certas injunções características dessa esfera discursiva. Esse fenômeno é um dos motivos pelos quais o quantitativo de citações tem sido utilizado como componente fundamental no cálculo de rankings ou índices bibliométricos para autores, artigos, periódicos e instituições. Defendemos que a referência ao trabalho de outros pesquisadores pode ser analisada em seu viés qualitativo, considerando-se suas formas e modalidades da relação entre pesquisadores, bem como sua função na escrita dos textos acadêmico-científicos, aspectos que escapam à medição quantitativa proporcionada por índices bibliométricos. Esta pesquisa analisa um corpus composto por 146 trabalhos, sendo (i) 91 trabalhos que citam cinco artigos científicos brasileiros publicados em revistas brasileiras e (ii) 55 trabalhos que citam um artigo científico em língua espanhola publicado em revista colombiana, todos da área do Direito e considerados de alto impacto. Foram analisadas as formas de citação e a modalidade da relação discursiva entre a posição do pesquisador citante e a do pesquisador citado, bem como a relação entre essas duas categorias. Os resultados revelaram uma significativa multiplicidade de formas e aspectos das citações, uma diversidade considerável na modalidade de gestão enunciativa, além de questões peculiares em cada um dos grupos do corpus. Igualmente fornecem argumentos consideráveis para questionar a eficácia do uso isolado de índices de produtividade e de qualidade baseados apenas em aspectos bibliométricos da citação, apontando-nos para a necessidade de serem consideradas e estudadas as questões discursivas que permeiam a prática da referência ao discurso de outros pesquisadores, inclusive em outros gêneros da comunicação científica.
Novos desafios em se fazer Divulgação Científica na contemporaneidade
Authors: Baracat De Grande Paula , Oliveira Gustavo André
Published: February 2025

O ensaio discute os desafios da Divulgação Científica (DC) frente às transformações provocadas pelas Tecnologias Digitais da Informação e Comunicação (TDICs), especialmente as redes sociais. Inicialmente, apresenta uma breve revisão histórica da DC, destacando sua importância para democratizar o conhecimento científico e aproximar a ciência do público. O ensaio, então, analisa a cibercultura como um cenário hipercomplexo, em que a integração de mídias redefine a relação entre produtores e consumidores de conhecimento. A DC, nesse contexto, enfrenta o desafio de adaptar-se às demandas de acessibilidade e interatividade sem comprometer a profundidade e a confiabilidade dos conteúdos. As práticas de retextualização e recontextualização na DC precisam ser investigadas à luz das novas mídias, em um esforço de entender e avaliar se a adaptação à lógica da fragmentação compromete a integridade ética e pedagógica da DC ou pode ser usada de forma estratégica para ampliar o alcance da ciência.
A atuação do professor indígena e a construção sociocultural da educação infantil da Comunidade Indígena Mata da Cafurna etnia Xucuru Kariri – AL
Authors: Felix Wellington Ricardo , Ferreira Lucideyne de Souza
Published: February 2025

A partir do tema “A atuação do professor indígena e a construção sociocultural na da educação infantil da Comunidade indígena Mata da Cafurna etnia Xucuru Kariri - AL.”, traz consigo uma compreensão a partir de um fundamento e embasamento teórico de acordo com a metodologia de cunho bibliográfico, buscou abordada a importância da valorização de suas culturas e a integração nas estruturas da sociedade e construindo uma fonte do conhecimento que se dá por meio da prática docente. Tendo como objetivo geral compreender como é inserida a valorização de diversos conhecimentos através do processo educativo, mais precisamente na Educação Infantil da Comunidade indígena Mata da Cafurna, da etnia Xucuru Kariri – Município de Palmeira dos Índios – AL, proporcionando assim, para as crianças um olhar que inclui a moralidade, etnicidade, estética, unidade e política, estabelecendo assim sua identidade pessoal na perspectiva da cultura indígena. Obtendo como resultado da pesquisa de que a essência da Educação Escolar Indígena Diferenciada está no diálogo com a Educação Escolar Tradicional respeitando seus costumes, crenças e tradições. Construindo portanto, a concluímos que a reflexão quanto a dimensão do papel do professor indígena, e de modo mais específico sobre a questão da mediação, permitindo afirmarmos que sua atuação tem como importância as práticas pedagógicas diferenciadas na Educação Escolar Indígena pois,  na Educação Escolar Indígena da Mata da Cafurna, a Educação Infantil destaca-se por meio das crianças e dos princípios essenciais para sua formação que elas internalizam valores como tempo e espaço, responsabilidade e comprometimento, direitos e deveres.
Narrativas que Educam: O Papel dos Memoriais Acadêmicos na Formação Docente
Authors: Nunes do Rosario Nyla , Alencar Isabelle da Costa Wanderley , Lúcia de Araújo Silva Silvania
Published: February 2025

Este estudo perscruta percepções dos licenciandos em Ciências Agrárias da Universidade Federal da Paraíba, participantes do Programa Residência Pedagógica (PRP), por meio da análise de memoriais acadêmicos. O objetivo primordial consiste em explorar suas motivações para aderir ao programa, documentar as experiências e elencar os desafios enfrentados por eles. Destaca-se a importância dos memoriais acadêmicos na reflexão sobre a prática pedagógica. Os licenciandos perceberam a relevância intrínseca deste registro, destacando sua capacidade de servir como um repositório da memória coletiva da educação. Dessa forma, este trabalho não apenas contribui para a compreensão da formação docente em Ciências Agrárias, mas também oferece uma perspectiva imersiva sobre a jornada formativa daqueles que abraçam o ofício de educador.
The impact of social responsibility strategy on the performance of listed firms
Authors: Ha Thi Phuong Dung , Tran Manh Dung , Phi Van Trong , Nguyen Thi Lan Anh , Truong Van Tu , Diep Nguyen Thi Thanh
Published: February 2025

This study is conducted to investigate the impact level of social responsibility practice on the performance of listed firms in an emerging country and Vietnam is a case study. Data are collected from the actual situations of social responsibility practices of Vietnamese listed firms for the period from 2019–2023. The list of 115 manufacturing companies was selected from the list of enterprises operating on the Vietnamese stock exchange system, namely the Ho Chi Minh Stock Exchange (HOSE), Hanoi Stock Exchange (HNX), and Unlisted Public Company Market (UPCOM) in 2019–2023. The study conducted data analysis through descriptive statistics and used multiple linear regression analysis methods based on Stata software. The study found a linear relationship between the net revenue variable and the practice of corporate social responsibility (CSR) according to the aspects of stakeholders (Zhang et al., 2012). The results illustrate the positive relationship between the social responsibility practice and performance which is proxied by the net revenue of listed firms. When listed firms guarantee income on shares to shareholders, advances in turnover payable to sellers, carry out good responsibility with customers, positive social work, and rational investment in the treatment of human resources, firms increase their performance.
Pediatric Cofactor-Enhanced Food Anaphylaxis (PCEFA): A Narrative Review of Epidemiology, Pathophysiology and Clinical Features
Authors: Mohta Alpana , Fernández Emilio Narváez , Mir-Ihara Patricia , Bartra Joan , Muñoz-Cano Rosa
Published: February 2025

Cofactors are external factors that can lower the threshold dose of an
allergen and amplify the severity of allergic reactions, turning mild or
moderate responses into severe anaphylaxis. These include exercise,
nonsteroidal anti-inflammatory drugs (NSAIDs), alcohol, menstruation,
and infections. Initially described in relation to food allergens and
physical activity or NSAIDs, these reactions have been labeled under
various terms, such as food-dependent exercise-induced anaphylaxis
(FDEIA), wheat-dependent exercise-induced anaphylaxis (WDEIA), and
food-dependent NSAID-induced anaphylaxis (FDNIA). However,
cofactor-enhanced food allergy (CEFA), a recently proposed concept,
serves as an umbrella term to encompass these conditions and is applied
in this text for consistency. Pediatric cofactor-enhanced food
anaphylaxis (PCEFA) is a rare but severe condition in which a food
allergy becomes significantly more severe in the presence of one or more
cofactors. Cofactors are documented in 14–18.3% of pediatric food
anaphylactic reactions, however, the true burden is likely higher due to
frequent underdiagnosis from variable and unpredictable presentations.
Exercise and infections are the most common cofactors in PCEFA, while
ω-5 gliadin is the predominant allergen. CEFA is frequently misdiagnosed
as idiopathic anaphylaxis, exercise-induced anaphylaxis (EIA), or asthma
when subtle or delayed food triggers go undetected. Some cases may
represent high-threshold food allergies rather than true
cofactor-dependent anaphylaxis, challenging conventional definitions.
Research on cofactors in anaphylaxis is still in its early stages, with
most studies focusing on adults. More research is needed to improve
diagnostic accuracy and treatment strategies for pediatric cases.
Patient Agency in Imaging: Radiologists’ Insights
Authors: Silva Lizzie De , Baysari Melissa , Keep Melanie , Kench Peter , Clarke Jillian
Published: February 2025

Objectives: There is a notable rise in patient-initiated imaging
requests, with one possible reason being the increased availability of
online health information. This study specifically examines the impact
of patient-initiated radiological exams on radiologists. Exploring their
perspectives on how GPs acquiescing to patients’ medical imaging
requests impacts healthcare resources and skew patients’ expectations of
the capabilities of radiological studies. The findings of this study are
crucial for understanding the evolving dynamics of radiology practice
and its challenges. Method: A comprehensive cross-sectional survey was
administered to radiologists in private medical centres across Australia
between November 2023 and February 2024. The survey included structured
and open-ended questions distributed via an intranet platform within the
same company and reached a wide range of radiologists. Results: Nearly
half of the participants (48%) had over 20 years of experience. The
majority of radiologists reported X-rays (27%), ultrasounds (25%), and
CT scans (24%) as the most commonly requested non-indicated imaging
studies. Radiologists attributed these requests to patients’ exposure to
online medical information and their desire for reassurance.
Approximately 24% of radiological studies were considered unnecessary,
with 30% of radiologists reporting feeling pressured by GPs and
patients to expedite report completion. Proposed strategies included
patient education, communication, and the establishment of clear
guidelines. Conclusions: The study underscores the increasing burden of
patient-initiated imaging on radiologists. This burden is further
compounded by patients’ unrealistic expectations and lack of
understanding of diagnostic imaging’s limitations. Radiologists have
stressed the crucial role of the broader healthcare context in
collaborating with such requests. Patient education was emphasised to
reduce unnecessary imaging and manage patient expectations.
Targeting SETD7 Rescues Diabetes-induced Impairment of Angiogenic Response by Transcriptional Repression of Semaphorin 3G
Authors: Mohammed Shafeeq A. , Gorica Era , Albiero Mattia , Karsai Gergely , Mengozzi Alessandro , Caravaggi Carlo Maria , Ambrosini Samuele , Masi Stefano , Vinci Maria Cristina , Dzemali Omer , Spinetti Gaia , Rajagopalan Sanjay , El-Osta Assam , Pelisek Jaroslav , Ruschitzka Frank , Fadini Gian Paolo , Costantino Sarah , Paneni Francesco
Published: February 2025

Revascularization strategies failed to improve outcome in diabetic (DM) patients with peripheral artery disease (PAD). Histone modifications are key modulators of gene expression and could play a role in angiogenic response. This study investigates the role of chromatin remodelling in modulating angiogenesis in DM. RNA sequencing (RNA-seq) and angiogenic assays (cell migration and tube formation) were performed in human aortic endothelial cells (HAECs) exposed to normal glucose (NG, 5 mM) or high glucose (HG, 25 mM) for 48h. The expression of the histone methyltransferase SETD7 and its chromatin signature at histone 3 on lysine 4 (H3K4me1) were investigated by Western blot and chromatin immunoprecipitation (ChIP). Diabetic mice were treated with the SETD7 inhibitor (R)-PFI-2 or vehicle and underwent hindlimb ischemia by femoral artery ligation. The experimental findings were translated into two cohorts of DM patients with PAD. RNA-seq in HG-treated HAECs unveiled SETD7 as the top-ranking transcript. SETD7 upregulation was associated with increased H3K4me1 levels and defective angiogenesis. Both SETD7 depletion and (R)PFI-2 rescued hyperglycemia-induced impairment of HAECs migration and tube formation, while SETD7 overexpression blunted the angiogenic response. RNA-seq and ChIP assays showed that SETD7-induced H3K4me1 enables the transcription of the angiogenesis inhibitor semaphorin- 3G (SEMA3G) by increasing chromatin accessibility to PPAR?. In diabetic mice with hindlimb ischemia, (R)-PFI-2 improved limb perfusion by suppressing SEMA3G. SETD7/SEMA3G axis was upregulated in DM patients with PAD. Of note, (R)-PFI-2 restored angiogenic properties in endothelial cells collected from DM patients. These findings show that SETD7 is a druggable epigenetic target in diabetic PAD.
Planificación territorial y sociología del espacio urbano: maniobras de resistencia e implicaciones jurídicas civiles de los nuevos falsos autónomos (El caso de Rappi en la ciudad de Quito)
Authors:   Universidad Técnica de Ambato, Ecuador., Sarzosa Soto Richard Esteban
Published: February 2025

Las plataformas digitales de economía colaborativa se han convertido en un modelo de mercado que progresivamente se ha implantado en la ciudad de Quito. La empresa Rappi –la cual propone este modelo de mercado–, se ha posicionado en los últimos meses de 2019 como una nueva plataforma que oferta el servicio de entrega de productos de consumo, dando lugar a que personas con baja cualificación profesional imposibilitadas de acceder al mercado laboral formal, apliquen a una plaza de trabajo y se subscriban a esta aplicación digital como maniobra de supervivencia ante su condición de inestabilidad laboral. Las términos y condiciones legales de trabajo que tiene la empresa por sobre los nuevos repartidores evidencian procesos de flexibilización laboral que reflejan diversas relaciones de control y poder por sobre los repartidores. La presente investigación busca responder si las maniobras de resistencia de repartidores de la plataforma digital Rappi frente a la precarización laboral son producto de estrategias colaborativas reflejadas en la formación incipiente de un “capital social comunitario” (Durston, 2000) y de una segregación espacial positiva (Sabatini, Cáceres y Cerdá, 2001).
THE IMPACT OF DIGITAL MARKETING ON MARKETING OUTCOMES OF SMES THE MEDIATING ROLE OF INNOVATIVE PRODUCT DEVELOPMENT
Authors: Sundari Eva , Afwa Awliya , Pratama Dani
Published: February 2025

Over recent decades, digital innovations in product creation, communication, and marketing have gained significant attention in research and decision-making across businesses of various scales. Technological advancements have greatly influenced corporate marketing strategies, consumer purchasing behav-ior, and market structures. This study examines the impact of digital marketing on marketing performance in Small and Medium Enterprises (MSME) in Pek-anbaru, with product innovation as a mediating factor. Targeting SMEs that utilize digital marketing, a purposive sampling method selected 53 Pekanbaru SMEs that met the research criteria. Path analysis through Structural Equation Modeling-Partial Least Squares (SEM-PLS) was applied as the analytical method. Findings indicate that digital marketing significantly enhances both marketing performance and product innovation. Furthermore, product innova-tion directly improves marketing performance, underscoring its role as a medi-ator in the relationship between digital marketing and marketing performance in Pekanbaru MSME.
Temperature dependences of the exchange bias in Dy-Co/FeNi bilayers
Authors: Svalov Andrey , Rusalina Anastasia
Published: February 2025

The work is devoted to the study of the magnetic properties of exchange-coupled Dy-Co/FeNi films in a wide temperature range. The temperature dependence of the spontaneous magnetization of the ferrimagnetic layer is the reason for the change in the order of magnetization reversal of the layers with a change in temperature. The efficiency of interlayer exchange interaction varies slightly with temperature.
Integrated climate project and carbon sequestration: From tree plantation to long-term wood deposition
Authors: Zelenova Maria , Vaganov Anatoly , Genkin Mikhail , Ginzburg Veronika , Korotkov Vladimir , Lipka Oksana , Lytov Vladislav , Sedova Anastasiia
Published: February 2025

To achieve the Paris Agreement’s temperature goal, greenhouse gas emissions should be reduced as soon as, and by as much, as possible. By mid-century, CO2 emissions would need to be cut to zero, and total greenhouse gases would need to be net zero just after mid-century. Achieving carbon neutrality is impossible without carbon dioxide removal from the atmosphere through afforestation/reforestation. It is necessary to ensure carbon storage for a period of 100 years or more. The study focuses on the theoretical feasibility of an integrated climate project involving carbon storage, emissions reduction and sequestration through the systemic implementation of plantation forestry of fast-growing eucalyptus species in Brazil, the production of long-life wood building materials and their deposition. The project defines two performance indicators: a) emission reduction units; and b) financial costs. We identified the baseline scenarios for each stage of the potential climate project and developed different trajectory options for the project scenario. Possible negative environmental and reputational effects as well as leakages outside of the project design were considered. Over 7 years of the plantation life cycle, the total CO2 sequestration is expected to reach 403 tCO2∙ha−1. As a part of the project, we proposed to recycle or deposit for a long term the most part of the unused wood residues that account for 30% of total phytomass. The full project cycle can ensure that up to 95% of the carbon emissions from the grown wood will be sustainably avoided.
Eddy current-based measurement system for evaluating fiber distribution to predict cracks in steel fiber-reinforced concrete: experimental study
Authors: Gherdaoui Loukmane , Bensaid Samir , Saoudi Nacira , Trichet Didier , Houassine Hamza
Published: February 2025

This paper presents a non-destructive approach for evaluating steel fiber distribution in Steel Fiber Reinforced Concrete (SFRC). The method utilizes a measurement system based on eddy currents combined with an automated scanning system, enabling precise sensor movements along the SFRC sample. The proposed method is first applied to a set of samples with known fiber distribution along the samples to test its effectiveness. The impedance response clearly indicates the highest and lowest fiber volume fractions along the samples, allowing for a straightforward correlation between the impedance data and fiber distribution through the established methodology. Then it is applied to another set of samples with random fiber distribution. In this case, the impedance response is compared to the Brazilian destructive test results. The obtained results affirm a robust correlation between impedance measurements and the observed cracks on the SFRC samples. This approach proves instrumental in identifying vulnerable areas susceptible to crack development in the SFRC sample. The comprehensive insights gained through this method contribute significantly to showing the detailed zonal distribution of SFRC which allows an understanding of the behaviour of the SFRC under mechanical stress.
Simple and accurate method to evaluate type a standard and expanded uncertainties of measurement for the Laplace distributed observations
Authors: Dorozhovets Mykhaylo
Published: February 2025

The article proposes and investigates a simple and accurate evaluation of the standard and expanded uncertainty of the Laplace population median. With the number of observations n, the known probability distribution describing the sample median for n-2 observations was used to approximate the uncertainty of the population median. The proposed approximation was tested by comparison with exact results for n  ≤  10 and with the Monte Carlo method. It has been shown that the standard and expanded (confidence level p = 0.90, 0.95, and 0.99) uncertainties determined by the proposed approximation differ from values determined by MCM by less than about 1%. Using the median instead of the mean value as the measurement result provides a measurement uncertainty lower by about 25% when n ≥ 35, and over 29% when n ≥ 70.
An AutoML-based comparative evaluation of machine learning methods for detection of eccentricity faults in induction motors by using vibration signals
Authors: Irgat Eyüp , Ünsal Abdurrahman
Published: February 2025

Induction motors (IMs) are the most widely used electrical machines in industrial applications. However, they are subject to various mechanical and electrical faults. Eccentricity faults are among the common mechanical faults of IMs. This study compares the performance of four commonly used machine learning (ML) methods, including k-nearest neighbours (k-NN), decision tree (DT), support vector machine (SVM), and random forest (RF) along with the statistical features in detecting eccentricity faults of IMs with an automated machine learning (AutoML) model. The aim of using AutoML in this study is to fully automate the process of detection of eccentricity faults of IMs by selecting the classifier with the highest accuracy rate and shortest computation time along with the most effective feature(s). The eccentricity fault analysed in this study was experimentally implemented in the laboratory. Three-axis vibration signals were collected for healthy and eccentricity-faulty IMs. In the proposed study the three-axis vibration signals are pre-processed to determine the statistical features that are used as input to the ML methods. The proposed study offers the best ML method among the four studied algorithms and the need for expert knowledge of ML and eccentricity fault detection. The proposed AutoML model offers the DT method along with the z-axis rms feature for the highest accuracy rate and the shortest computation time in detecting the eccentricity fault.
Coupling error model of 3-DoF-compliant stage based on parallelogram mechanism
Authors: Qiang Huaibo , Wang Hongxi , Huang Qiang
Published: February 2025

Compliant mechanisms are the state-of-the-art in precision Compliant Parallelogram Stage (CPS) due to their many beneficial features. However, the translational motion of CPS is accompanied by parasitic displacement and coupling error in these mechanisms. In this paper, the parasitic displacements are analysed by firstly applying the pseudo-rigid-body theory to One-Degree of Freedom (1-DoF) CPS. Then the theoretical model of the Coupling Error Transfer Matrix (CETM) is presented on a Three-Degree of Freedom (3-DoF) serial CPS. Moreover, the general forms of CETM are developed for the various configurations of 3-DoF-compliant mechanisms. In addition, the coupling error model is validated through experiment on a 1-DoF CPS. Meanwhile, the analytical results are validated with Finite Element Analysis (FEA) by comparing the parasitic displacements on each coordination axial direction. Compared with the analysis results between theoretical calculation and the FEA method, the maximum difference of the parasitic displacement is about 0.18 uμ and the relative error of about 6.22%. This result offers effective ways to calculate and compensate for the coupling errors and serves to facilitate further work regarding the precision analysis of compliant mechanisms.
Algorithm for compensation of external influences upon metal oxide gas sensors using the datasheet characteristics
Authors: Fosalau Cristian , Cornei Doru , Zet Cristian
Published: February 2025

Gas sensors, like any other type of sensors, are affected by external influencing factors among which the most aggressive are the ambient temperature and humidity. If the influence is small, their effect on the global accuracy of the sensor is reduced, and the error caused by these factors is included in the admissible error provided in the datasheet. However, if the influence ais significant, their effect can no longer be neglected and compensation of these errors is necessary based on the known influence characteristics found in the datasheet of the sensor. Unfortunately, these characteristics are not linear and the compensation must be accomplished according to an analytical relationship, if it can be known, or based on look-up tables implemented in the memory of the measuring device. Things get complicated when there are several influence factors. The paper describes a method for compensating the influence of ambient temperature and humidity on an MQ7 metal oxide gas (MOG) sensor, mainly dedicated to measuring carbon monoxide (CO), by mathematically modelling the surfaces of the characteristics given in the sensor’s datasheet and their implementation on a microcontroller platform. Experimental data show that, for a temperature variation between 10 and 50 Celsius degrees (°C) and a relative humidity (RH) variation between 30 and 90%, a reduction of the total amount of error is obtained by compensating the influence quantities resulting in an accuracy improvement of more than 60%.
In vitro use of a low-level laser therapy device inhibits growth of Malassezia pachydermatis
Authors: Gil Natalia , Santoro Domenico , Marsella Rosanna
Published: February 2025

Objective

To determine the in vitro activity of the low-level laser (light) therapy (LLLT) device (Phovia; Vetoquinol) on Malassezia pachydermatis.

Methods

Clinical isolates of M pachydermatis (n = 30) and a commercially available anamorph of M pachydermatis (ATCC strain 14522) were used in this study. Both groups of organisms were plated on potato agar plates and exposed to the LLLT device for 2, 4, 6, and 8 minutes with a 30-second break after every 2 minutes of exposure. The plates were then incubated at 37 °C for 48 hours. Each experiment was run in duplicate. The experiment for the internal control was repeated independently 6 times. Nonirradiated plates served as the viability control (positive control). The number of CFUs between each treatment and the control was analyzed using a repeated-measures ANOVA or a Friedman test followed by a post hoc analysis.

Results

Compared to the control, there was a statistically significant decline in CFUs after a minimum of 4 minutes of exposure to the LLLT device in both groups compared to unexposed controls.

Conclusions

This preliminary in vitro study demonstrated that the LLLT device tested can inhibit the growth of M pachydermatis.

Clinical Relevance

This in vitro study offers a novel proof-of-concept approach to treating Malassezia infections in veterinary medicine. Low-level laser (light) therapy has the potential to shorten treatment durations and reduce side effects, making it a promising alternative to standard antifungal therapy, particularly in the context of antifungal resistance.
Equine bone marrow aspirate and bone marrow aspirate concentrate are enriched with interleukin-1 receptor antagonist protein
Authors: Long Sidney , Maleas Grigorios , Belacic Zarah A. , Quam Vivian G. , Durgam Sushmitha
Published: February 2025

Objective

To analyze the cellular, growth factor, and cytokine composition of equine sternal bone marrow aspirate (BMA) and laboratory-centrifuged BMA concentrate (BMAC).

Methods

This was an in vitro experimental study. Cellular composition, growth factors (IGF-I, VEGF, PDGF, TGF-β1), and cytokines (IL-6, IL-10, tumor necrosis factor-α (TNF-α), and IL-1 receptor antagonist protein [IL-1Ra]) were quantified using a standard automated hematology analyzer and ELISA methods, respectively, in donor-matched BMA, BMAC (in-house centrifugation protocol), whole blood, and platelet-rich plasma (E-PET; Pall Inc) prepared from 25 horses from 2016 through 2020.

Results

Leukocytes, neutrophils, monocytes, lymphocytes, and thrombocytes were increased 4.1-, 3.4-, 4.6-, 4.4-, and 2.5-fold in BMAC compared to BMA, respectively. Interleukin-1 receptor antagonist protein of BMAC was increased 21-fold compared to BMA and increased 117-fold compared to gravity filtration system–based, leukocyte-rich platelet-rich plasma.

Conclusions

Laboratory centrifugation enriches the cellular and IL-1Ra concentrations of equine BMAC compared to BMA, with no significant changes in IGF-I, VEGF, PDGF, TGF-β1, IL-6, IL-10, or TNF-α concentrations.

Clinical Relevance

Equine BMA and BMAC are patient-side biologics enriched with anti-inflammatory IL-1Ra and support further evaluation of equine BMAC for musculoskeletal tissue healing.
Recurrent respiratory papillomatosis: role of bevacizumab and HPV vaccination. A literature review with case presentations
Authors: Sporeni Silvio , Rifaldi Francesca , Lanzetta Irene , Imarisio Ilaria , Montagna Benedetta , Serra Francesco , Agustoni Francesco , Pedrazzoli Paolo , Benazzo Marco , Bertino Giulia
Published: February 2025

Background

Recurrent respiratory papillomatosis (RRP) is a condition caused by human papilloma virus (HPV) infection. Curative treatments aren’t identifiable, and conservative surgery is often the best option to preserve respiratory functions. To date monoclonal antibodies are considered to be a treatment choice with both good efficacy and safety profile.

Materials and methods

A web-based search of MEDLINE/PubMed library from 2000 to 2024 of English-language papers was performed to identify articles by using “respiratory or laryngeal papillomatosis” and “HPV respiratory infection, papillomatosis treatment, papillomatosis vaccine immunization, papillomatosis systemic treatment”. Furthermore, a manual screening of references from original articles was done to identify additional studies. We selected 34 articles.

Results

Since 2009, the systemic administration of Bevacizumab has been used to treat RRP not responding to surgical treatment. The efficacy of an anti-VEGF monoclonal antibody in RRP lesions can be related to their vascular nature. The major concern is the rebound papilloma growth within the cessation of treatment. An interesting solution could be the concomitant use of immunotherapy to both reduce the burden of residual disease and activate the immune system against the HPV-infected cells.

Conclusions

Bevacizumab has a safe profile with a short-term local eradication of HPV. Further prospective research with long-term follow-up is needed to better define its safety and results against the disease recurrence. Considering the role of the anti-HPV vaccine, both, in the prophylaxis of the infection and in the adjuvant setting, the actual data underline the need for evaluation of its therapeutic efficacy for the management of RRP.
Comparison of 2D and 3D radiomics features with conventional features based on contrast-enhanced CT images for preoperative prediction the risk of thymic epithelial tumors
Authors: Yuan Yu-Hang , Zhang Hui , Xu Wei-Ling , Dong Dong , Gao Pei-Hong , Zhang Cai-Juan , Guo Yan , Tong Ling-Ling , Gong Fang-Chao
Published: February 2025

Background

This study aimed to develop and validate 2-Dimensional (2D) and 3-Dimensional (3D) radiomics signatures based on contrast-enhanced computed tomography (CECT) images for preoperative prediction of the thymic epithelial tumors (TETs) risk and compare the predictive performance with conventional CT features.

Patients and methods

149 TET patients were retrospectively enrolled from January 2016 to December 2018, and divided into high-risk group (B2/B3/TCs, n = 103) and low-risk group (A/AB/B1, n = 46). All patients were randomly assigned into the training (n = 104) and testing (n = 45) set. 14 conventional CT features were collected, and 396 radiomic features were extracted from 2D and 3D CECT images, respectively. Three models including conventional, 2D radiomics and 3D radiomics model were established using multivariate logistic regression analysis. The discriminative performances of the models were demonstrated by receiver operating characteristic (ROC) curves.

Results

In the conventional model, area under the curves (AUCs) in the training and validation sets were 0.863 and 0.853, sensitivity was 78% and 55%, and specificity was 88% and 100%, respectively. The 2D model yielded AUCs of 0.854 and 0.834, sensitivity of 86% and 77%, and specificity of 72% and 86% in the training and validation sets. The 3D model revealed AUC of 0.902 and 0.906, sensitivity of 75% and 68%, and specificity of 94% and 100% in the training and validation sets.

Conclusions

Radiomics signatures based on 3D images could distinguish high-risk from low-risk TETs and provide complementary diagnostic information.
THE APPLICABILITY OF DOMESTIC LAW IN INTERNATIONAL BUSINESS CONTRACTS: A STUDY ON INDONESIAN COURTS' CASES
Authors: Bintang Sanusi
Published: February 2025

This article explores the application of domestic law and forum selection clauses in international business contracts within Indonesian legal system. It provides an analysis of the legal reasoning behind two significant court cases: Beauchamp Guerin v. Gunarsa and AXN v. Karyamegah. Utilizing a normative legal research methodology, the study examines these cases alongside relevant statutes, adopting a case-based approach rather than a strictly statutory one. The selected cases were chosen for their relevance to the intersection of international business contracts and domestic law, particularly in relation to forum selection clauses. The analysis is grounded in legal reasoning, demonstrating that the principles of choice of law and choice of forum support the applicability of domestic law and forum selection clauses in international business contracts, bolstered by Indonesian contract law. In Beauchamp Guerin v. Gunarsa, the court upheld the domestic law by affirming the validity of the contract and recognizing issues of nonperformance and damages in accordance with Indonesian law. Similarly, in AXN v. Karyamegah, the court asserted its jurisdiction over the case, finding grounds for nonperformance and damages as well. The findings presented in this article are significant for Indonesia, particularly in light of the absence of specific legislation governing international business contracts. Thus, this research serves both theoretical and practical purposes, filling a gap in existing literature that has predominantly focused on the application of foreign national laws and forums while overlooking the importance of domestic legal frameworks.
CYBER DEFAMATION IN INDONESIA'S NATIONAL CRIMINAL CODE: AN ANALYSIS OF THE NEW PROVISIONS
Authors: Abdaud Faisal , Haris Oheo Kaimuddin
Published: February 2025

This article investigates the impact of cyber defamation regulations within Indonesia's National Criminal Code (NCC), a topic worthy of investigation due to the significant changes in the definition and scope of cyber defamation offenses following the NCC's enactment. Through a normative legal research approach, the study examines legal rules, principles, and doctrines, employing both statutory and conceptual analyses. The findings indicate that the NCC's provisions on cyber defamation, as lex generalis, take precedence over Article 27 paragraph (3) of the Information and Electronic Transactions (ITE) Act, while Article 27A of the Second Amendment to the ITE Law remains in provisional effect until the NCC's full implementation in 2026. Notably, cyber defamation is addressed in seven articles (Articles 433-439) within the NCC, which also specifically cover defamation against the President, government, and state institutions. To mitigate potential ambiguities, the development of implementing regulations is recommended to clarify the application of these NCC defamation provisions. The changes align with established legal principles, ensuring a coherent and effective regulatory framework. This article contributes to a deeper understanding of the NCC's new cyber defamation provisions by analyzing their scope, implications, and the need for implementing regulations to ensure consistent and effective application.
REVITALIZING MURABAHAH FINANCING AGREEMENT IN INDONESIA: A RETURN TO ISLAMIC PRINCIPLES FOR SOCIETAL WELFARE
Authors: Dayyan Muhammad , Abbas Syahrizal , Furqani Hafas
Published: February 2025

The transformation of Murabahah trade agreements into Murabahah financing agreements in banking institutions since the 1970s signifies a significant shift in the Islamic financial landscape. Intended to promote an economy that is just and blessed by Allah SWT, the murabahah financing agreement is a crucial instrument in realizing this goal. However, the evolution of this agreement from a straightforward trading pattern to a credit-based model in Islamic banking has deviated from the original Islamic financing characteristics, rendering it similar to conventional banking practices. This study argues that murabahah financing in Indonesian Islamic banking necessitates three key improvements. Firstly, a unified concept of the murabahah financing agreement should be formulated, consolidating the perspectives of the National Sharia Council of the Indonesian Ulama Council, the Financial Services Authority, Bank Indonesia, and the Indonesian Islamic banking sector. Secondly, the seven Islamic economic principles (tawhid, khalifah, 'adalah, amanah, shura', ta'awun, and ta'aruf) should be actualized in the terms and conditions of murabahah financing agreements between banks and customers. Lastly, the implementation of murabahah financing agreements should be centered on enhancing and developing customers' assets, aligning with the fundamental principles of Islamic finance
NAVIGATING THE CHALLENGES AND OPPORTUNITIES OF THE WTO'S TRADE FACILITATION AGREEMENT IN INDONESIA
Authors: Maulana Mursal , Adolf Huala
Published: February 2025

The Trade Facilitation Agreement (TFA) is a significant multilateral trade accord adopted by the World Trade Organization (WTO) to streamline the movement, release, and clearance of goods. Indonesia ratified the TFA through Law No. 17 of 2017 and has implemented 87.7% of its Category A commitments, along with 11.3% of Category B commitments. Despite this progress, Indonesia faces challenges such as regulatory complexities, bureaucratic inefficiencies, coordination issues, and technical constraints. This article explores these challenges and the potential economic benefits of fully implementing the TFA, especially in Indonesia’s international trade. Using a juridical-normative approach, the article identifies key issues that need to be addressed, including legislative harmonization, streamlined bureaucratic processes, improved digital infrastructure, and better coordination in trade facilitation governance. It also highlights the advantages of the TFA, such as reduced trade barriers, increased efficiency, and enhanced global competitiveness. To overcome existing challenges and maximize the benefits of TFA implementation, Indonesia should focus on regulatory harmonization, inter-agency coordination, and upgrading digital trade infrastructure. Strengthening the National Trade Facilitation Committee (NTFC), modernizing customs automation, and expanding the Indonesia National Single Window (INSW) will improve efficiency and lower costs, thereby solidifying Indonesia's position in the global trading system.
LEGAL FRAMEWORKS FOR SPECTRUM SHARING: UNLOCKING INDONESIA'S BROADBAND POTENTIAL
Authors: Kosasih Achmad Arizki , Ramli Tasya Safiranita , Virhani Mohan Rifqo
Published: February 2025

This article analyzes the application of spectrum sharing regulations in mobile broadband technology in Indonesia. Since 2019, the country has witnessed significant progress in the widespread adoption of 4G LTE broadband network infrastructure. However, the development of 5G telecommunications technology remains nascent, operating in a non-standalone mode that relies on existing 4G LTE infrastructure and is currently available only in several major cities. To improve service quality and increase accessibility to 4G LTE and 5G broadband networks, a clear and comprehensive legal framework is essential. This framework should facilitate the sharing of 4G LTE infrastructure, particularly radio frequency spectrum, with 5G technology, thereby enhancing broadband coverage in underdeveloped, frontier, and outermost regions. The Indonesian government has enacted the Job Creation Law, which addresses spectrum sharing in the telecommunications sector. This research employs a normative juridical approach, integrating both primary and secondary data analysis to examine the legal framework governing spectrum sharing. It specifically investigates the impact of the Job Creation Law on the implementation of spectrum sharing in Indonesia's telecommunications landscape.  The findings indicate that the current spectrum sharing policy is insufficiently supportive of 4G LTE technology, thereby impeding the deployment of 5G non-standalone technology in underdeveloped, frontier, and outermost areas. To remedy this situation, spectrum sharing policies must ensure non-discriminatory access, be responsive to market demands, and adapt to technological advancements. Moreover, the study highlights the importance of collaborative efforts among stakeholders in crafting spectrum sharing provisions that address the needs of both 4G LTE and 5G technologies.
EFFECTIVENESS OF CRIMINAL SANCTIONS FOR VIOLATORS OF SMOKE-FREE AREAS IN INDONESIA: CHALLENGES AND RESPONSIVE LAW SOLUTIONS
Authors: Darma I Made Wirya , Mahadnyani Tjokorda Mirah Ary
Published: February 2025

Cigarettes pose a significant global health threat, resulting in millions of related deaths annually. Consequently, governments worldwide, including Indonesia, have implemented smoke-free area policies in an effort to mitigate these health concerns. This study analyzes the effectiveness of criminal sanctions imposed on violators of smoke-free areas in Indonesia, while identifying legal challenges in enforcing these regulations and proposing normative solutions within the framework of responsive law. Utilizing a normative legal approach, this study combines both statutory and conceptual methodologies to analyze primary, secondary, and tertiary legal materials through literature studies. It employs a qualitative descriptive analysis method to examine the efficacy of criminal sanctions against violators of smoke-free areas in the context of responsive law. The results indicate that the effectiveness of criminal sanctions to enforce smoke-free areas in Indonesia is hindered by various constraints, including weak law enforcement, limited public awareness, economic conflicts of interest, and inadequate smoking facilities. This study recommends adopting a responsive law approach. This entails strengthening law enforcement, conducting continuous socialization and education programs, establishing special smoking facilities, involving the tobacco industry in health policy-making, and reformulating policies through a participatory approach. By implementing these responsive law solutions, it is anticipated that smoke-free area regulations can be more effectively enforced, garner the support of all parties involved, and contribute to enhanced public health protection from the risks associated with cigarette smoke.
To Death Comes Life: Alfonso Bovero's longevity in Renato Locchi's speech to the São Paulo Society of Medicine and Surgery
Authors: Tavano Patricia Teixeira
Published: February 2025

Objective: To analyze the construction of a mythology around the name of Alfonso Bovero based on a speech given by his disciple, Renato Locchi, to the São Paulo Society of Medicine and Surgery after his death.
 
Theoretical Reference: Alfonso Bovero was the first Professor of Anatomy at the Faculty of Medicine of São Paulo, and was responsible for the construction of its anatomical teaching and research space, which led the chair to international recognition. Brought here by Arnaldo Vieira de Carvalho, Bovero had the firm intention of creating an Anatomical School here, based on his scientific method of bibliographic rigor and empirical data collection, and fostering disciples who would continue his work. When he died, he left his legacy to Renato Locchi who, alongside expanding the consolidation of teaching and research in the chair, undertook actions to perpetuate the figure of Bovero.
 
Method: The methodology adopted for this research comprises primary document analysis, in a text constructed in the form of an essay.
 
Results and Discussion: Here we present Locchi's speech to the São Paulo Society of Medicine and Surgery, a few months after the master's death, in an attempt to indicate the construction of Bovero as a myth representing an anatomical tradition at the Casa de Arnaldo.Locchi constructs an enviable past, legitimizes his presence by linking it to an institutional myth, and bases his construction on three communities: anatomical, academic and São Paulo.This means that Bovero does not disappear and becomes a great anatomical tradition of the São Paulo 'Casa de Arnaldo'.
 
Research Implications: The practical and theoretical implications of this research include the analysis of a little-discussed historical document and the application of mythical construction analysis to the person.
 
Originality/Value: This study contributes to the understanding of the construction of the myth of Alfonso Bovero at USP's Faculty of Medicine, based on the analysis of a little-discussed document.