bluuebunny/crossref_metadata_2025 huggingface dataset:
The Prognostic Value and Clinical Significance of lncRNA SNHG5 Expression in Patients with Multiple Malignancies: A Bioinformatic and Meta-analysis
Authors: Pashirzad Mehran , Sahebkar Amirhossein
Published: February 2024

Background:

Long non-coding RNA small nucleolar RNA host gene 5 (lncRNA SNHG5)
has been identified as both a promising target for treatment and a predictor of prognosis in
diverse types of cancer. The objective of this study was to assess whether lncRNA SNHG5 expression
can be utilized as a prognostic biomarker for human cancer.

Methods:

To ensure a thorough search of the literature for relevant English studies published before
July 2023, several databases were searched, including PubMed, Web of Science, ProQuest,
Cochrane Library, and Google Scholar. The study evaluated the impact of lncRNA SNHG5 on the
overall survival (OS) of cancer by calculating the pooled hazard ratio (HR) and odds ratio (OR)
with 95% confidence intervals (CIs). To further confirm the accuracy of the findings, the study investigated
the expression profile and prognostic significance of lncRNA SNHG5 through the use
of GenomicScape, OncoLnc, Kaplan-Meier plotter, and GEPIA databases.

Results:

In this study, 995 patients were examined across a total of fourteen original studies. The
findings indicated that there was a significant relationship between heightened lncRNA SNHG5
expression and reduced OS, as evidenced by both univariate and multivariate analyses (HR =
1.89; 95% CI, 1.44-2.49; p < 0.001; HR = 3.97; 95% CI, 1.80-8.73; p < 0.001, respectively).
Pooled OR analysis showed a significant association between over-expression of lncRNA SNHG5
with advanced histological grade (OR = 0.28; 95% CI, 0.11-0.71; p = 0.007), present lymph node
metastasis (LNM; OR = 4.28; 95% CI, 2.47-7.43; p < 0.001), and smoking history (OR = 0.27;
95% CI, 0.15-0.49; p < 0.001). Bioinformatic databases confirmed that elevated SNHG5 expression
was significantly linked to poor prognosis in cancer patients, including colorectal cancer (CRC),
acute myeloid leukemia (AML), and esophageal adenocarcinoma (ESAD), and a longer OS in
patients with uterine corpus endometrial carcinoma (UCEC).

Conclusion:

These results suggest that lncRNA SNHG5 may serve as an adverse prognostic biomarker
in several human cancers. Further investigations are needed to better understand the underlying
mechanisms that link lncRNA SNHG5 to multiple malignancies.
Introduction of Honeycomb (Nidus Vespae) and Some of Its Most Important
Pharmacological Benefits
Authors: Shahrajabian Mohamad Hesam , Sun Wenli
Published: February 2024

Background:

Nidus Vespae (honeycomb), which is a well-known traditional Chinese
medicine, is the honey-comb of Polistes japonicus Saussure, Parapolybia varia Fabricius, or
Polistes olivaceus (De Geer), and it is usually harvest in winter and autumn.

Methods:

Its chemical component is completely complex combining honey, pollen, royal jelly,
and propolis and consequently has a significant number of bioactive components such as nitro
compounds, flavonoids, and polyphenols. It has shown various pharmacological impacts, such as
anti-inflammatory, anti-viral, anti-microbial, and anti-tumor effects.

Results:

In this review article, all relevant papers from various scholars and researchers were
searched in Science Direct, Google Scholar, PubMed, and Scopus. Honeycomb has various activities
and numerous pharmacological benefits and health advantages, and it can be considered a
valuable source of nutraceuticals, and an effective natural medicine and organic product.

Conclusion:

In this mini-review, we have decided to discuss the importance of traditional treatment,
and the pharmacological properties of Nidus Vespae
Exploration of Potential Cyclin-dependent Kinases and their Inhibitors to
Combat Abnormal Signalling and Cancer
Authors: Pilania Pradeep , Nandi Sisir , Meena Dinesh Kumar , Sharma Brij K.
Published: February 2024

Regulation of cell proliferation depends on stimulatory and inhibitory factors that act
in a coordinated manner in response to external signals. Various agents, including mitogens,
growth factors, cytokines, and other external factors, can impact the mitotic cell cycle, resulting
in either provoking growth, differentiation, or apoptosis. Many kinases, such as protein kinases,
regulate mitotic cell proliferation through normal signalling. One of the major protein kinase
family members is cyclin-dependent kinases (CDK), which are responsible for the regulation of
cell cycle progression. If the cell cycle-regulatory mechanisms are permanently altered, it can
cause abnormal proliferation that leads to neoplasia. This can result in tumour development,
where the availability and expression of CDKs become altered, contributing significantly to impaired
cell proliferation. Changes like these are often a characteristic of cancer. CDK inhibitors
have shown significant clinical benefits in treating various types of tumours in recent years. The
output has been achieved by the clinical approvals of particular CDK inhibitors. Researchers
have also been studying the proteolysis-targeting chimera (PROTAC) molecule for the last two
decades. This molecule uses ubiquitin-mediated proteasome mechanisms to break down specific
targets, making it a promising method for targeted protein degradation (TPD). TPD has become
a promising therapeutic option for tackling disease-causing proteins that are otherwise challenging
to treat using traditional small molecules. This review provides an overview of the state of
knowledge and a general understanding of selective or nonselective CDK inhibitors and
PROTAC degraders currently under development or clinically approved congeners, focusing on
improving cancer therapy.
Recent Advances in Chemistry, Mechanism, and Applications of Quantum Dots in
Photodynamic and Photothermal Therapy
Authors: Ranjbari Faride , Fathi Farzaneh
Published: February 2024

Semiconductor quantum dots (QD) are a kind of nanoparticle with unique optical properties that have
attracted a lot of attention in recent years. In this paper, the characteristics of these nanoparticles and their applications
in nanophototherapy have been reviewed. Phototherapy, including photodynamic therapy (PDT) and
photothermal therapy (PTT), has gained special importance because of its high accuracy and local treatment due
to the activation of the drug at the tumor site. PDT is a new way of cancer treatment that is performed by activating
light-sensitive compounds named photosensitizers (PS) by light. PSs cause the destruction of diseased tissue
through the production of singlet oxygen. PTT is another non-invasive method that induces cell death through the
conversion of near-infrared light (NIR) into heat in the tumor situation by the photothermal agent (PA). Through
using energy transfer via the FRET (Förster resonance energy transfer) process, QDs provide light absorption
wavelength for both methods and cover the optical weaknesses of phototherapy agents.
Analgesic and Anti-inflammatory Potential of the New Tetrahydropyran
Derivative (2s,6s)-6-ethyl-tetrahydro-2h-pyran-2-yl) Methanol
Authors: Castro Gustavo Nunes de Santana , de Souza Raquel do Nascimento , da Silva Alba Cenélia Matos , Laureano-Melo Roberto , da Silva Côrtes Wellington , Capim Saulo Luis , de Almeida Vasconcellos Mário Luiz Araujo , Marinho Bruno Guimarães
Published: February 2024

Background:

The development of analgesic and anti-inflammatory drugs plays a crucial role in modern medicine, aiming to alleviate pain and reduce inflammation in patients. Opioids and nonsteroidal anti-inflammatory drugs are groups of drugs conventionally used to treat pain and in-flammation, but a wide range of adverse effects and ineffectiveness in some pathological conditions leads us to search for new drugs with analgesic and anti-inflammatory properties.

Objectives:

In this regard, the authors intend to investigate the ((2s,6s)-6-ethyl-tetrahydro-2h-pyran-2-yl) methanol compound (LS20) on pain and acute inflammation.

Methods:

Male Swiss mice were evaluated using acetic acid-induced abdominal writhing, formalin, and tail-flick as models of nociceptive evaluation and edema paw, air pouch and cell culture as models of inflammatory evaluation besides the rotarod test for assessment of motor impairment.

Results:

The compound showed an effect on the acetic acid-induced abdominal writhing, formalin and tail-flick tests. Studying the mechanism of action, reversion of the antinociceptive effect of the compound was observed from previous intraperitoneal administration of selective and non-selective opioid antagonists on the tail flick test. In addition, the compound induced an antiedematogenic effect and reduced leukocyte migration and the production of pro-inflammatory cytokines in the air pouch model. LS20 was able to maintain cell viability, in addition to reducing cell production of TNF-α and IL-6.

Conclusion:

In summary, the LS20 compound presented an antinociceptive effect, demonstrating the participation of the opioid system and an anti-inflammatory effect related to the inhibition of pro-inflammatory cytokine production. The compound also demonstrated safety at the cellular level.
Effectiveness of Novel Drug Delivery System using Curcumin in
Alzheimer’s Disease
Authors: Aswar Urmila , Rathod Kundlik , Mathure Dyandevi
Published: February 2024

:

Alzheimer's disease (AD) is a form of brain degeneration that gradually impairs a
person's memory and cognitive skills, eventually making it harder for them to perform everyday
activities. Its pathophysiology has been attributed to the deposition of amyloid β (Aβ),
neurofibrillary tangles (NFT), and α-synuclein (A-s) in some cases. Presently, 4 drugs have been
approved for the treatment. They are Donepezil, Rivastigmine, Galantamine and Memantine. The
first three are acetylcholinesterase inhibitors, while memantine is an NMDA receptor antagonist.
Even though these medications are successful in treating mild to moderate Alzheimer's disease,
they have not been able to reverse the disease or even slow its progression completely. Hence,
natural products are gaining more popularity due to the advantage of the multitarget intervention
effect. The most investigated spice, Curcuma longa's bioactive component, curcumin, has
demonstrated anti-amyloid, anti-NFT, and anti-Lewy body properties and substantial antiinflammatory,
antioxidant, and antiapoptotic properties. However, its proven neuroprotective
activity is hampered by many factors, such as poor water solubility and bioavailability. Therefore,
many novel formulations have been designed to improve its bioavailability with methods such as 1)
Micellar Solubilization, 2) Cyclodextrin Complexation, 3) Crystal Modification, and 4) Particle
Size Reduction, etc. The current chapter aims to summarize various novel formulations of curcumin
and their effectiveness in treating AD.
The Role of Ocimene in Decreasing α-Synuclein Aggregation using
Rotenone-induced Rat Model
Authors: Suresh Ankul Singh , Sood Aarita , Vellapandian Chitra
Published: February 2024

Background:

Parkinson’s disease is defined by the loss of dopaminergic neurons in
the midbrain of substantia nigra associated with Lewy bodies. The precise mechanism is not
yet entirely understood.

Objective:

The study aims to determine whether ocimene has antiparkinsonian activity by reducing
α-Synuclein aggregation levels in the brains of rotenone-induced rat models.

Methods:

36 male rats were used for six groups, with six animals in each group. Vehicle, control
(rotenone, 2.5 mg/kg, i.p), standard (L-Dopa, 10 mg/kg, i.p), Test drug of low dose (66.66
mg/kg, i.p), medium dose (100 mg/kg, i.p), and high dose (200 mg/kg, i.p) were administered to
the rats. The open field, actophotometer, hanging wire, and catalepsy tests were used to assess
the rat’s motor performance. The expressions of biomarkers such as AchE, D2 Receptor, and α-
Synuclein were evaluated, and their level of expression in the brain samples was checked using
ELISA. Histopathological analysis was also carried out to determine the degree of neuron degeneration
in the brain samples.

Results:

The open field test showed significant anxiety levels, whereas test groups showed
fewer anxiety levels but increased motor activity. The biochemical tests revealed that rotenonetreated
rats had higher levels of AchE, but ocimene-treated rats had a significant decrease in
AchE levels. The test drug-treated rats also expressed high levels of D2 receptors. In ocimenetreated
rats, α-Synuclein aggregation was reduced, however, in rotenone-treated rats' brain samples,
higher clumps of α-Synuclein were observed.

Conclusion:

Ocimene has neuroprotective properties. As a result, this essential oil might be
helpful as a therapeutic treatment for Parkinson's disease.
Emerging Treatments for Subarachnoid Hemorrhage
Authors: Findlay Matthew C. , Kundu Mrinmoy , Nelson Jayson R. , Cole Kyril L. , Winterton Candace , Tenhoeve Samuel , Lucke-Wold Brandon
Published: February 2024

:

The current landscape of therapeutic strategies for subarachnoid hemorrhage (SAH), a
significant adverse neurological event commonly resulting from the rupture of intracranial aneurysms,
is rapidly evolving. Through an in-depth exploration of the natural history of SAH, historical
treatment approaches, and emerging management modalities, the present work aims to provide a
broad overview of the shifting paradigms in SAH care. By synthesizing the historical management
protocols with contemporary therapeutic advancements, patient-specific treatment plans can be individualized
and optimized to deliver outstanding care for the best possible SAH-related outcomes.
O USO DO TRACKER PARA O ESTUDO DE ROLAMENTO NO PLANO INCLINADO
Authors: De Oliveira Gurgel Rebouças Gustavo , Alves Mendes Gustavo , Costa e Silva Jusciane
Published: February 2024

O momento de inércia é um parâmetro de extrema relevância para objetos em rolamento e, por muita das vezes, negligenciado no ensino médio. Para o estudo da conservação da energia mecânica, a energia cinética rotacional também deve ser considerada. Apresentamos uma montagem experimental de um plano inclinado no qual esferas de diferentes raios e massas rolam sem deslizar, tendo seu movimento gravado por uma câmera de celular. A medida da posição e velocidade em função do tempo é realizada com uso do Traker, um software de análise de vídeo, que possibilita ao discente identificar graficamente as funções horárias da posição e da velocidade ao longo da descida a partir do repouso. Os resultados apresentam uma boa correlação entre a análise teórica e o experimento. A conservação da energia é obtida considerando a energia cinética de rotação, usualmente não considerada.
ACESSIBILIDADE EM TECNOLOGIAS DE INFORMAÇÃO E COMUNICAÇÃO ENQUANTO RECURSO PEDAGÓGICO
Authors: Oliveira Márcia Cristina Conceição Santos , Silva Núbia Xavier da , Silva Maria do Carmo Lobato da
Published: February 2024

Neste artigo apresenta-se uma revisão de artigos em que as Tecnologias de Informação e Comunicação são utilizadas como recurso pedagógico na inclusão escolar de alunos com deficiência e/ou transtornos globais de desenvolvimento, baseando-se em artigos publicados no Google Acadêmico e Scielo no período de 2017 a 2021. Empregaram-se os descritores tecnologias digitais de informação e comunicação, inclusão escolar e tecnologias digitais acessíveis e analisaram-se: os objetivos, o tipo de deficiência, os periódicos que publicaram os artigos, os resultados e as conclusões. Excluíram-se: os artigos fora dos critérios definidos. Como resultado, foram encontrados 44 artigos e apenas 5 contemplaram a temática. Os estudos analisados indicaram que apesar das lacunas existentes entre as diretrizes legais e a realidade precária nas escolas brasileiras, os professores desenvolvem estratégias pedagógicas com o uso de tecnologias de informação e comunicação com alunos com algum tipo de deficiência.
JORNADA DUPLA E ADOECIMENTO
Authors: Oliveira Roberta Lúcia Santos de , Pereira Lidiane da Silva , Fialho Lia Machado Fiuza
Published: February 2024

Este estudo tem por objetivo compreender de que maneira o percurso formativo e o profissional da professora Josefa Paula Fialho Saraiva, caracterizados pelo excesso de trabalho, levaram ao adoecimento físico e mental da educadora. Com o acúmulo dos cargos de professora do município de Maracanaú e de Fortaleza, Josefa atuou em sala de aula e como gestora por anos, submetendo-se a uma jornada de 300 horas mensais. Trata-se de uma pesquisa biográfica, amparada teoricamente nos pressupostos da História Cultural e metodologicamente na História Oral. Assim, busca-se compreender as contribuições deste estudo de caso para a história da educação do Ceará. O recorte temporal é de 1989 a 2022. Os resultados apontam que o acúmulo de trabalho foi determinante no processo de adoecimento da educadora. Além disso, o tratamento dado pelos superiores de Josefa, como ignorá-la e não envolvê-la nas atividades do setor, acentuou o seu processo de adoecimento.
Optimization of Screening Strategies for COVID-19: Scoping Review
Authors: Liu Yuanhua , Yin Yun , Ward Michael P , Li Ke , Chen Yue , Duan Mengwei , Wong Paulina P Y , Hong Jie , Huang Jiaqi , Shi Jin , Zhou Xuan , Chen Xi , Xu Jiayao , Yuan Rui , Kong Lingcai , Zhang Zhijie
Published: February 2024

Background

COVID-19 screening is an effective nonpharmaceutical intervention for identifying infected individuals and interrupting viral transmission. However, questions have been raised regarding its effectiveness in controlling the spread of novel variants and its high socioeconomic costs. Therefore, the optimization of COVID-19 screening strategies has attracted great attention.

Objective

This review aims to summarize the evidence and provide a reference basis for the optimization of screening strategies for the prevention and control of COVID-19.

Methods

We applied a methodological framework for scoping reviews and the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) checklist. We conducted a scoping review of the present publications on the optimization of COVID-19 screening strategies. We searched the PubMed, Web of Science, and Elsevier ScienceDirect databases for publications up to December 31, 2022. English publications related to screening and testing strategies for COVID-19 were included. A data-charting form, jointly developed by 2 reviewers, was used for data extraction according to the optimization directions of the screening strategies.

Results

A total of 2770 unique publications were retrieved from the database search, and 95 abstracts were retained for full-text review. There were 62 studies included in the final review. We summarized the results in 4 major aspects: the screening population (people at various risk conditions such as different regions and occupations; 12/62, 19%), the timing of screening (when the target population is tested before travel or during an outbreak; 12/62, 19%), the frequency of screening (appropriate frequencies for outbreak prevention, outbreak response, or community transmission control; 6/62, 10%), and the screening and detection procedure (the choice of individual or pooled detection and optimization of the pooling approach; 35/62, 56%).

Conclusions

This review reveals gaps in the optimization of COVID-19 screening strategies and suggests that a number of factors such as prevalence, screening accuracy, effective allocation of resources, and feasibility of strategies should be carefully considered in the development of future screening strategies.
Identification of Predictors for Clinical Deterioration in Patients With COVID-19 via Electronic Nursing Records: Retrospective Observational Study
Authors: Sung Sumi , Kim Youlim , Kim Su Hwan , Jung Hyesil
Published: February 2024

Background

Few studies have used standardized nursing records with Systematized Nomenclature of Medicine–Clinical Terms (SNOMED CT) to identify predictors of clinical deterioration.

Objective

This study aims to standardize the nursing documentation records of patients with COVID-19 using SNOMED CT and identify predictive factors of clinical deterioration in patients with COVID-19 via standardized nursing records.

Methods

In this study, 57,558 nursing statements from 226 patients with COVID-19 were analyzed. Among these, 45,852 statements were from 207 patients in the stable (control) group and 11,706 from 19 patients in the exacerbated (case) group who were transferred to the intensive care unit within 7 days. The data were collected between December 2019 and June 2022. These nursing statements were standardized using the SNOMED CT International Edition released on November 30, 2022. The 260 unique nursing statements that accounted for the top 90% of 57,558 statements were selected as the mapping source and mapped into SNOMED CT concepts based on their meaning by 2 experts with more than 5 years of SNOMED CT mapping experience. To identify the main features of nursing statements associated with the exacerbation of patient condition, random forest algorithms were used, and optimal hyperparameters were selected for nursing problems or outcomes and nursing procedure–related statements. Additionally, logistic regression analysis was conducted to identify features that determine clinical deterioration in patients with COVID-19.

Results

All nursing statements were semantically mapped to SNOMED CT concepts for “clinical finding,” “situation with explicit context,” and “procedure” hierarchies. The interrater reliability of the mapping results was 87.7%. The most important features calculated by random forest were “oxygen saturation below reference range,” “dyspnea,” “tachypnea,” and “cough” in “clinical finding,” and “oxygen therapy,” “pulse oximetry monitoring,” “temperature taking,” “notification of physician,” and “education about isolation for infection control” in “procedure.” Among these, “dyspnea” and “inadequate food diet” in “clinical finding” increased clinical deterioration risk (dyspnea: odds ratio [OR] 5.99, 95% CI 2.25-20.29; inadequate food diet: OR 10.0, 95% CI 2.71-40.84), and “oxygen therapy” and “notification of physician” in “procedure” also increased the risk of clinical deterioration in patients with COVID-19 (oxygen therapy: OR 1.89, 95% CI 1.25-3.05; notification of physician: OR 1.72, 95% CI 1.02-2.97).

Conclusions

The study used SNOMED CT to express and standardize nursing statements. Further, it revealed the importance of standardized nursing records as predictive variables for clinical deterioration in patients.
Current Situation and Construction Path of Integration of Shandong Red Cultural Resources into University Campus Culture
Authors: Qun Shi
Published: February 2024

Shandong red cultural resources are abundant, which are an indispensable and important cultural form in the construction of university campus culture. However, there are still deficiencies in the integration of content, methods, channels, and mechanisms between the two. This article explores paths of integration of Shandong red cultural resources into university construction of campus culture from various perspectives, including establishing and improving Shandong’s Red Cultural Resource database to enrich the Connotation of Campus Culture Construction, enhancing the practicality and participation of Shandong red cultural resources to activate the main body of campus cultural construction, enriching the dissemination carriers of Shandong red cultural resources to expand the channels of campus cultural construction and establishing a comprehensive integration mechanism to stimulate the endogenous driving force of campus cultural construction.
Characteristics and Development Trends of Network Mass Incidents in Colleges and Universities
Authors: Feng Huaifang , Chen Yong
Published: February 2024

With the leapfrog progress of mobile internet technology, the network mass incidents in colleges and universities are increasingly concerned by many parties. The characteristics of network mass incidents in colleges and universities include the particularity of participants, the diversity of inducement causes, emotionalization and irrationalization, the non-confrontational nature of event and the extensive range of impact. With social development, the potential trends of future network mass incidents in colleges and universities include the probability and quantity of occurrences will further increase, the breadth and intensity of impact will be further enhanced, the organizational form will become more complex, the coping strategies of management department will affect the development trend of the event, the increase in uncertainty brought by the development of new technologies.
Coronavirus (CoV) proteins in GtoPdb v.2023.3
Authors: Alexander Stephen P.H. , Ball Jonathan K. , Tsoleridis Theocharis
Published: February 2024

Coronaviruses are large, often spherical, enveloped, single-stranded positive-sense RNA viruses, ranging in size from 80-220 nm. Their genomes and protein structures are highly conserved. Three coronaviruses have emerged over the last 20 years as serious human pathogens: SARS-CoV was identified as the causative agent in an outbreak in 2002-2003, Middle East respiratory syndrome (MERS) CoV emerged in 2012 and the novel coronavirus SARS-CoV-2 emerged in 2019-2020. SARS-CoV-2 is the virus responsible for the infectious disease termed COVID-19 (WHO Technical Guidance 2020).
NADPH oxidases in GtoPdb v.2023.3
Authors: Van der Vliet Albert
Published: February 2024

The two DUOX enzymes were originally identified as participating in the production of hydrogen peroxide as a pre-requisite for thyroid hormone biosynthesis in the thyroid gland [9].NOX enzymes function to catalyse the reduction of molecular oxygen to superoxide and various other reactive oxygen species (ROS). They are subunits of the NADPH oxidase complex.
The Impact of Project Management Practice on Public Project Success in Jimma Town, Ethiopia
Authors: Mesera Eyuel , Fikadu Sisay Yohannis , Ginbare Gutu Tesfaye
Published: February 2024

Purpose: The study aimed to examine the effect of project management practice on project success on selected public projects found in Jimma town, Ethiopia.
Methodology/approach: The study was employed stratified simple random sampling techniques and total sample size of 155 was selected from public sector projects. The data were collected with self-administered questionnaires and key informant interview. The data coded and interred into the. The data were analyzed with descriptive and inferential statistics such as Mean, ANOVA, Pearson correlation and the Multiple Regression Analysis Model using SPSS software application for analysis.
Findings: The results of regrssion revealed that project initiation & planning was positively and significantly associated with project success (r =0.735, ρ<0.01). Further, project execution process was positively and significantly correlated to project success (r = 0.659, ρ<0.01). Moreover, monitoring & controlling was positively and strongly correlated with project success (r = 0.747, ρ<0.01) and also there is a positive correlation between project closure & project success (r = 0.348, ρ<0.01).
Practical implications: These research findings have an impact on stakeholders and policy makers regarding project management. The study recommends the introduction of effective monitoring tools and documentation in order to improve the monitoring and control process.
Originality/value: The study can contribute to knowledge sharing and capacity building within Ethiopia's project management community, leading to more effective implementation of projects and improved development outcomes.
Iustitia et misericórdia: o conceito de justiça na obra de Santo Agostinho
Authors: Vahl Matheus Jeske
Published: February 2024

Com a graça imprime-se na consciência e no coração humano o que Agostinho chama de “Lei da caridade”. Com ela o dever moral é cumprido não apenas pelo temor da punição, por vezes sem o entendimento de seu sentido, mas por amor à justiça e seus efeitos, ou seja, trata-se da regra cumprida não por medo da punição, mas com liberdade, sem a soberba de Adão e com a humildade dos justos [...].Na encarnação o natural é assumido pelo sobrenatural em um ato de humildade onde Deus realiza a justiça realiza com misericórdia. Ela se expressa na graça como ato gratuito de Deus ao homem; sua finalidade é recuperar a integridade da criação que foi maculada, por isso, não é contrária à liberdade, mas confluente a ela. Neste mesmo sentido, não tem o peso de uma norma, mas a qualidade de uma virtude, que se cultivada no coração humano lhe purifica e assemelha a Deus. A partir do evento da encarnação estabelece-se um paradoxo entre a virtude da humildade negada por Adão e assumida por Deus e o vício da soberba assumido por Adão e negado por Deus, é Cristo que realiza esta inversão abrindo à humanidade um novo horizonte moral.
Aplicabilidade da lei penal brasileira para assassinos em série
Authors:   , Santério Camila
Published: February 2024

O presente estudo tem como objetivo analisar a aplicação da lei penal brasileira nos casos de crimes cometidos por assassinos em série, por meio do estudo da legislação, doutrina e jurisprudência. Especificamente, a pesquisa busca levantar o histórico desses crimes, conceituá-los, classificá-los, identificálos e compreender se esses criminosos são considerados imputáveis, se há possibilidade de reintegração à sociedade e, caso não haja, quais medidas devem ser adotadas. Os assassinos em série costumam cessar sua prática somente quando são detidos ou mortos, e o código penal brasileiro não apresenta disposições específicas para esses casos. No entanto, existem diversas disposições legais que podem ser aplicadas aos crimes cometidos por esses indivíduos, de acordo com as circunstâncias específicas de cada caso. Diante disso, é importante ressaltar a necessidade de criação de uma instituição voltada para a identificação, tratamento e gerenciamento desses indivíduos, uma vez que eles cometeram crimes graves e violentos motivados por fatores emocionais e psicológicos complexos. Devido à falta de estudos aprofundados sobre o tema, há uma enorme lacuna na preparação das autoridades para identificar e tratar esses criminosos de forma adequada, visando sua reintegração à sociedade. Caso não haja possibilidade de reinserção social, a Lei de Execução Penal prevê que, em casos de extrema periculosidade do condenado, a pena de prisão pode ser cumprida em regime fechado por prazo indeterminado.
Aplicabilidade da progressão de regime para reeducando que cumpre pena em regime disciplinar diferenciado
Authors:   , Baptistella Mariane
Published: February 2024

Neste artigo científico trata-se do regime disciplinar diferenciado, o qual deu-se a ser nacional após a publicação da Lei nº 10.792 de 1º de Dezembro de 2003, que modificou a redação do Artigo 52, entre outras, da Lei de Execução Penal. Tem po finalidade analisar as hipóteses de aplicabilidade e cabimento do regime disciplinar diferencial, onde impõe ao preso um regime (sanção disciplinar) de cumprimento da pena de prisão muito mais rigoroso, podendo ser aplicada de duas formas, sanção disciplinar e medida de caráter cautelar nas progressões de regimes dentro das unidades prisionais; a contribuição para a ressocialização e apontar melhorias no desenvolvimento entre os reeducando dentro do estabelecimento prisional e com a sociedade. Portanto, é indispensável analisar o conceito e origem histórica dele no Brasil, expor a viabilidade e a aplicação; analisar os tipos de progressões de regime com a utilização do Regime Disciplinar Diferenciado. Desenvolve-se então, uma pesquisa com intuito básico estratégico, objetivo, descritivo e será realizada com pesquisas bibliográficas, doutrinas, jurisprudências e artigos.
Strategiczne dylematy polityki rolnej w Polsce w procesie integracji z UE
Authors: Majewski Edward
Published: February 2024

Istnieje potrzeba sformułowania długoterminowej strategii dla polskiego rolnictwa w oparciu o scenariusz akcesji do Unii Europejskiej. Zarówno w Polsce, jak i w UE politykę rolną charakteryzuje silna orientacja protekcjonistyczna, z dominacją celów krótkoterminowych, bardzo często podważających długoterminowe cele strategiczne, które należy wiązać z koncepcją zrównoważonego rozwoju. Na podstawie analizy tendencji rozwojowych w rolnictwie światowym oraz przewidywanych zmian w politykach rolnych w UE, zaproponowaną strategię dla polskiego rolnictwa określono jako zrównoważony, kierowany rynkiem, rozwój obszarów wiejskich i rolnictwa. Strategia ta opiera się na czterech ogólnych strategiach: wzrost produktywności, zrównoważony rozwój, orientacja rynkowa i rozwój obszarów wiejskich.lw
Regionalne zróżnicowanie sytuacji dochodowej ludności rolniczej prowadzącej dodatkową działalność gospodarczą
Authors: Stolarska Alicja
Published: February 2024

The paper presents the income situation of 210 farms running non-agricultural economic activity in 2000. An analysis was conducted according to farms division by voivodships. The results of the research display regional differentiation of the level of personal income and its structure in the investigated farms. Moreover, the primary sources of income generated by farms located in individual voivodships were shown.
Koszty i korzyści z inwestycji w budowle do składowania nawozów organicznych w gospodarstwach z produkcją zwierzęcą w Polsce
Authors: Majewski Edward , Straszewski Sławomir , Wąs Adam
Published: February 2024

W artykule przedstawiono wyniki analizy inwestycji w obiekty do składowania odchodów zwierzęcych w polskich gospodarstwach rolnych, niezbędne do spełnienia wymagań unijnej Dyrektywy azotanowej. Skonstruowano modele liniowe (wykorzystujące optymalne funkcje celu) 88 typów gospodarstw, w tym mleczarskich, trzodowych i mieszanych, aby obliczyć zarówno koszty i korzyści inwestycji, jak i zbadać ich wpływ na poziom dochodów gospodarstw. Oszacowano, że obecnie około 20-25% polskich gospodarstw jest zadowalająco wyposażonych zgodnie z wymogami Dyrektywy. Rozwiązania większości modeli gospodarstw rolnych pokazują, że niezbędne inwestycje mają niewielki negatywny wpływ na dochody gospodarstw. Bariery finansowe i niski stopień świadomości ekologicznej rolników można uznać za poważne przeszkody w budowie infrastruktury ekologicznej gospodarstw. Biorąc pod uwagę przewidywalne korzyści społeczne inwestycji ekologicznych, można stwierdzić, że zasadne byłoby albo bezpośrednie wsparcie finansowe, albo jakiekolwiek zachęty dla programów inwestycyjnych. Można jednak kwestionować wsparcie inwestycji publicznych dla małych gospodarstw rolnych, gdyż spodziewana koncentracja w produkcji zwierzęcej prawdopodobnie obniży się w najbliższej przyszłości i nastąpi zaprzestanie chowu zwierząt w takich gospodarstwach.lw
Zmiany w handlu zagranicznym Polski produktami rolno-spożywczymi w latach 1989-2001
Authors: Stańko Stanisław
Published: February 2024

W artykule przedstawiono tendencje w polskim handlu zagranicznym artykułami rolno-spożywczymi w latach 1989-2001. Wyniki analizy wskazują, że handel rolno-spożywczy ma tendencję wzrostową, jednak dynamika eksportu była niższa w porównaniu z importem. W rezultacie Polska jest importerem netto produktów rolno-spożywczych. Deficyt w polskim handlu rolno-spożywczym tworzył głównie bilans handlu rolnego. W obszarze eksportu rolno-spożywczego główny partner handlowy – kraje UE, zmniejszył swój udział z około 63% średnio w latach 1989-1991 do około 48% obecnie, podczas gdy zarówno kraje byłego Związku Radzieckiego, jak i kraje CEFTA były coraz ważniejszymi partnerami. Polski eksport rolno-spożywczy kierowany do krajów byłego Związku Radzieckiego zwiększył swój udział z 5% do 20%, podczas gdy w przypadku krajów CEFTA z 1,8% do 11,8%. W latach 1989-2001 dynamika eksportu do UE była 2,4 razy niższa w porównaniu do eksportu ogółem. Oznacza to stopniową reorientację przepływów handlowych w kierunku regionów spoza Unii Europejskiej. Statystyki pokazują rosnący udział importu z UE i CEFTA, przy jednoczesnym spadku udziału krajów EFTA w polskim imporcie rolno-spożywczym. tłum. - lw
Zestawienie tytułów artykułów opublikowanych w okresie styczeń 1995 - wrzesień 2005; od numeru 27 do 55
Authors: ZN EiOGŻ Komitet Redakcyjny
Published: February 2024

W roku 2005 upływa 10 lat od reaktywowania serii Ekonomika i Organizacja Gospodarki Żywnościowej (poprzedni tytuł: Ekonomika i Organizacja Rolnictwa) w Zeszytach Naukowych Szkoły Głównej Gospodarstwa Wiejskiego. Oddajemy w ręce Państwa zestawienie tytułów artykułów opublikowanych w okresie styczeń 1995 - wrzesień 2005; od numeru 27 do 55, zamieszczono w nich ponad 400 artykułów, wszystkie publikacje były recenzowane. Naszymi Autorami byli pracownicy naukowi Wydziału Ekonomiczno-Rolniczego i katedr o kierunku ekonomicznym, społecznym i humanistycznym SGGW. Udostępnialiśmy łamy pisma osobom zatrudnionym w szkołach wyższych, instytutach naukowo-badawczych, administracji centralnej i terenowej oraz praktykom.
Cardiovascular and Kidney Risks in Individuals With Type 2 Diabetes: Contemporary Understanding With Greater Emphasis on Excess Adiposity
Authors: Sattar Naveed , Presslie Calum , Rutter Martin K. , McGuire Darren K.
Published: February 2024

In high-income countries, rates of atherosclerotic complications in type 2 diabetes have declined markedly over time due to better management of traditional risk factors including lipids, blood pressure, and glycemia levels. Population-wide reductions in smoking have also helped lower atherosclerotic complications and so reduce premature mortality in type 2 diabetes. However, as excess adiposity is a stronger driver for heart failure (HF), and obesity levels have remained largely unchanged, HF risks have not declined as much and may even be rising in the increasing number of people developing type 2 diabetes at younger ages. Excess weight is also an underrecognized risk factor for chronic kidney disease (CKD). Based on evidence from a range of sources, we explain how excess adiposity must be influencing most risks well before diabetes develops, particularly in younger-onset diabetes, which is linked to greater excess adiposity. We also review potential mechanisms linking excess adiposity to HF and CKD and speculate on how some of the responsible pathways—e.g., hemodynamic, cellular overnutrition, and inflammatory—could be favorably influenced by intentional weight loss (via lifestyle or drugs). On the basis of available evidence, we suggest that the cardiorenal outcome benefits seen with sodium–glucose cotransporter 2 inhibitors may partially derive from their interference of some of these same pathways. We also note that many other complications common in diabetes (e.g., hepatic, joint disease, perhaps mental health) are also variably linked to excess adiposity, the aggregated exposure to which has now increased in type 2 diabetes. All such observations suggest a greater need to tackle excess adiposity earlier in type 2 diabetes.
Clinical Case Reports 1992 - 94
Authors: Rao* P Syamasundar
Published: February 2024

Five interesting cases reported between 1992 and 1994 were reviewed. The first case documents successful treatment of chylothorax with balloon angioplasty of baffle obstruction following Mustard operation. The second case illustrates successful relief of supra-valvar pulmonary artery stenosis that developed after arterial switch procedure by balloon dilatation. In the third case, shock-like syndrome developed in an 11-day-old baby with severe aortic coarctation which was relieved by balloon angioplasty; the procedure was performed via the umbilical artery, sparing the femoral artery. The fourth case documents percutaneous occlusion of patent ductus arteriosus with a buttoned device in an adult patient; this was first case of using this device in an adult patient. The final case points to late clinical presentation of the origin of the anomalous circumflex coronary artery from the pulmonary artery several years following repair of aortopulmonary window in infancy. Surgical correction of this anomaly was successfully accomplished. The cases presented successful use of catheter or surgical interventional procedures to address uncommon types of cardiac problems.
Uncovering EFL students’ frequent difficulties in academic writing and the coping strategies: The case of a college in Indonesia
Authors: Asnas Sania Alinda Mouli , Hidayanti Ika
Published: February 2024

Presently, writing research articles causes anxiety for EFL students because they have to modify their writing to fit the English academic writing style, so academic writing is the most difficult skill to master because it requires an intricate process. Therefore, this study aims to uncover the frequent difficulties of academic writing and the coping strategies faced by EFL students. This study used a mixed method. Fifty-five participants from the English Department at a private university in Malang, Indonesia, filled out the questionnaire, and five participants were interviewed. The quantitative data were analyzed using descriptive statistics, and the qualitative data were analyzed thematically. The results showed that students experienced frequent difficulties, namely structure, developing ideas, vocabulary, and grammar, and the most frequent difficulty was grammar. To overcome challenges in grammar aspects, there were four manual coping strategies that they applied such as reading more articles, looking carefully at the function of conjunction, learning more about spelling, capitalization, and punctuation, and editing their work, and three automatic coping strategies that they used, namely using Grammarly, using an online English monolingual dictionary, and using Microsoft Word. The implications are to assist students in identifying and overcoming their frequent difficulties when writing academically.
Learning Styles and Academic Achievement of Distance e-Learning University Mathematics Students: A Case of a University in Zimbabwe
Authors: Mangwende Edmore
Published: February 2024

This article reports on a study to determine whether there was a relationship between the learning styles and academic performance of university mathematics students learning through distance e-learning. 26 students studying for a Bachelor of Science degree in Mathematics and Statistics at a university in Zimbabwe participated in the study. The study revealed a statistically significant relationship between the students’ learning styles and academic performance. The researcher recommended that the methods used in instructing distance learners should be designed and structured to accommodate all students despite their different learning styles. The learning content should be provided in multiple formats, allowing students to share and discuss concepts. The researcher also recommended an intentional mismatch between the mode of instruction and the students’ learning styles. The mismatch helps to make the students versatile. Online workshops and seminars on using e-learning methods were also recommended to equip the students with study skills that suit their learning styles
Programa de intervención virtual para afrontar el impacto del COVID-19 sobre la salud mental en trabajadores de emergencia de un hospital privado - Lima 2022
Authors: Palomino Basagoitia Carlos Alberto
Published: February 2024

Objetivo: Determinar la efectividad diferencial de un programa de intervención destinado a disminuir el impacto sobre la salud mental (ansiedad, estrés y depresión) por COVID-19 en trabajadores de emergencia de un hospital privado en el año 2022. Metodología: Se trató de una investigación de enfoque cuantitativo, descriptiva, transversal, prospectiva y cuasi experimental pre y post test con grupo control. La muestra estuvo constituida por 52 trabajadores de emergencia de un hospital privado (la misma que la población) en los que se administró el cuestionario DASS 21 para diagnóstico de compromiso de salud mental (ansiedad, estrés y depresión); luego se llevó a cabo el programa de cuatro sesiones en el grupo de intervención y se volvió a administrar el instrumento a los dos grupos. Se utilizó la prueba de t de Student para comparar los resultados de los niveles de ansiedad, estrés y depresión después de la intervención. Resultados: Se encontró que los trabajadores de la salud participantes en el estudio (52) 40,4% tenía algún grado de ansiedad, 17,3% algún grado de estrés y 5,8% algún grado de depresión. Después de la aplicación del programa en el grupo de intervención se mostró diferencia en la media de los niveles de ansiedad (6,81 - 3,08), estrés (5,31-1,69) y depresión (2,50-1,50); esta diferencia fue estadísticamente significativa para los niveles de ansiedad y estrés (p < 0,05). Conclusiones: Los resultados revelan una efectividad diferencial del programa propuesto que se pone de manifiesto en el beneficio adquirido por los trabajadores con compromiso de ansiedad, estres y depresion participantes del programa; que se ve reflejado en el cambio observado en la medición de ansiedad, estrés y depresión evaluada con el instrumento DASS-21 aplicado después del programa.
Índices reproductivos en vacunos Brown Swiss, Jersey y Holstein en altura – cooperativa Atahualpa Jerusalén – Cajamarca
Authors: Ruiz Figueroa Erickson Alvaro , Alvarado Malca Armando Enrique , Bueno Cabrera Wilder Aristides
Published: February 2024

El objetivo del estudio fue evaluar en condiciones de altura, y sistema semi – extensivo, durante el periodo 1999 al 2013, en la Cooperativa Agraria de Trabajadores CAT “Atahualpa Jerusalén”- Cajamarca, los índices reproductivos de vaquillas y vacas de las razas Jersey, Holstein y Brown Swiss, utilizándose 685, 115 y 690 registros reproductivos para cada una de las razas respectivamente. El ANOVA, se hizo conforme al diseño de Bloques Completamente al Azar (DBCA), mediante el paquete estadístico Statistix versión 8. La raza Jersey con 19,7 meses, fue más precoz en la Edad al Primer Servicio (EPS), habiendo diferencias (p<0,05) respecto de la Holstein y Brown Swiss con 23,8 y 25 meses; pero presentó 2,1 Números de Servicios por Concepción (NSC), siendo mayor (p<0,05) que las otras dos razas. Los días de gestación, fueron de 279,1, 280,7 y 288,3 para Jersey, Holstein y Brown Swiss respectivamente encontrándose diferencias (p<0,05) de ésta última respecto a las anteriores, aunque no se encontraron diferencias (p<0,05) para el Intervalo Parto Concepción (IPC) ni parael Intervalo Entre Partos (IEP) entre las razas. La Tasa de Concepción (TC) más baja fue para la Jersey con 85,5% siendo diferente (p<0,05) que la Holstein (96,3%), pero no con la Brown Swiss (90,7%). Las Tasas de Preñez (TP%) fueron de 54,7% para la Jersey y Brown Swiss y de 58,3 para la Holstein; y la Natalidad (N%) fue de 96,7%, 95,4% y 98,4% para las razas Jersey, Holstein y Brown Swiss. Tanto en TP% como en N%, no se encontraron diferencias entre las razas. Se concluye que las tres razas muestran signos de adaptabilidad a la altitud y sistema de manejo de la CAT Atahualpa Jerusalén.
SF6 Intracameral para Desprendimiento de Membrana de Descemet: una complicación postquirúrgica de la Cirugía de Catarata
Authors: Tello Arquíñego Johans Neil
Published: February 2024

El Desprendimiento de la Membrana de Descemet (DMD) es una complicación ampliamente descrita, que se origina durante o posterior a procedimientos intraoculares como cirugías de catarata o trabeculectomías, presentándose de manera central, periférica o combinada, llegando en muchos casos, a resolverse de manera espontánea. Cuando el desprendimiento ocurre de manera intraoperatoria y se llega a tratar de forma temprana, los resultados en su mayoría son satisfactorios, sin embargo, cuando el diagnóstico es tardío, el pronóstico visual puede ser reservado. Se presenta el caso clínico de un paciente de 83 años, sometido a una cirugía de facoemulsificación sin complicaciones, que presentó edema corneal persistente sin mejoría de la agudeza visual (AV) en el post operatorio, se realizó una Tomografía de Coherencia óptica de Segmento Anterior (AS-OCT) apreciándose un DMD siendo tratado con hexafluoro de azufre (SF6) al 20%. El edema corneal ser resolvió, presentando una agudeza visual mejor corregida (AVMC) de 20/30 a las 2 semanas.  
Palabras Clave: Desprendimiento membrana Descemet, Cirugía de catarata, edema corneal.