bluuebunny/crossref_metadata_2025 huggingface dataset:
Multiparametric Magnetic Resonance Imaging, 68Ga Prostate-Specific Membrane Antigen Positron Emission Tomography–Computed Tomography, and Respective Quantitative Parameters in Detection and Localization of Clinically Significant Prostate Cancer in Intermediate- and High-Risk Group Patients
Authors: Kubihal Vijay , Sharma Sanjay , Kumar Rakesh , Seth Amlesh , Kumar Rajeev , Kaushal Seema , Sarangi Jayati , Gupta Ravikant , Das Chandan Jyoti
Published: December 2021

Objectives:

The objective of this study was to evaluate the diagnostic accuracy of multiparametric magnetic resonance imaging (mpMRI) and 68Ga prostate-specific membrane antigen positron emission tomography–computed tomography (PSMA PET-CT) and respective quantitative parameters (Ktrans – influx rate contrast, Kep – efflux rate constant, ADC – apparent diffusion coefficient, and SUVmax ratio – prostate SUVmax to background SUVmax ratio) in detection and localization of clinically significant prostate cancer (CSPCa) in D’Amico intermediate- and high-risk group patients (prostate-specific antigen [PSA] >10 ng/ml).

Methodology:

The study included thirty-three consecutive adult men with serum prostate specific antigen >10ng/ml, and systematic 12 core prostate biopsy proven prostate cancer. All the 33 patients, were evaluated with mpMRI, and 68Ga PSMA PET-CT. The biopsy specimens and imaging were evaluated for 12 sectors per prostate by a predetermined scheme.

Results:

MpMRI Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) score ≥3 showed higher sensitivity than 68Ga PSMA PET-CT (96.3% vs. 82.4%), with similar specificity (54.5% vs. 54.5%) (n = 33 patients, 396 sectors). Combined use of MRI and 68Ga PSMA PET-CT in parallel increased sensitivity (99.5%) and NPV (98.7%) for detection of CSPCa and combined use of MRI and 68Ga PSMA PET-CT in series increased specificity (71.8%) and PPV (71.5%) (n = 33 patients, 396 sectors). ADC showed a strong negative correlation with Gleason score (r = −0.77), and the highest discriminative ability for detection and localization of CSPCa (area under curve [AUC]: 0.91), followed by Ktrans (r = 0.74; AUC: 0.89), PI-RADS (0.73; 0.86), SUVmax ratio (0.49; 0.74), and Kep (0.24; 0.66).

Conclusion:

MpMRI PI-RADS v2 score and 68Ga PSMA PET-CT (individually as well as in combination) are reliable tool for detection and localization of CSPCa. Quantitative MRI and 68Ga PSMA PET-CT parameters have potential to predict Gleason score and detect CSPCa.
Utility and feasibility of a six-color multiparametric flow cytometry for measurable residual disease analysis in plasma cell myeloma in resource-limited settings with 5-year survival data
Authors: Sharma Praveen , Singh Sachdeva Man Updesh , Varma Neelam , Bose Parveen , Aggarwal Ritu , Malhotra Pankaj
Published: December 2021

Introduction:

Treatment of multiple myeloma (MM) has evolved over decades with the introduction of novel therapeutic strategies. Response rates has significantly improved; however, there is a need for more sensitive techniques to study the residual disease other than conventional means. We evaluated the feasibility and utility of a two-tube six color multiparametric flow cytometry (MFC) assay for measurable residual disease (MRD) detection in MM patients on treatment.

Methodology:

Pretitrated cocktails containing antibodies against CD38, CD138, CD45, CD19, CD56, CD81, CD27, and cytoplasmic kappa and lambda light chains were used in the combination of two tubes and were acquired on a flow cytometer. Limit of detection was determined through dilution and spiking experiments with a limit of 0.01%.

Results:

Of the 62 patients screened, 58 patients were included in the final study cohort (day 100 postautologous stem cell transplant and at the end of induction chemotherapy). Twenty-eight patients (48%) revealed the presence of MRD in bone marrow on MFC (median = 0.12, range = 0.01–5.89%). Out of 28 MFC-MRD positive patients, only 16 patients showed M band on immunofixation-electrophoresis (IFE) (MRD+/IFE+, 57%), and rest of them were IFE negative (MRD+/IFE-, 42%). Patients with MRD positive status at the end of induction chemotherapy or day 100 posttransplant had an inferior overall survival (P = 0.009) and progression-free survival (P = 0.0002) than those with MRD negativity.

Conclusion:

We have demonstrated the impact of MRD testing in MM using MFC with a long follow-up data, suggesting its routine incorporation in monitoring the disease independent of the immunofixation status.
Pulmonary pleomorphic carcinoma in an elderly patient treated with pembrolizumab shows a marked response
Authors: Yamasaki Masahiro , Matsumoto Yu , Nakamoto Kanako , Hattori Noboru
Published: December 2021

Pulmonary pleomorphic carcinoma, a relatively rare histopathological subtype of non-small cell lung cancer, is a malignant neoplasm with a poor prognosis. Despite the reports of a good response to immune-checkpoint inhibitor, only a few reports of pembrolizumab as the first-line treatment exist. We report the case of a 78-year-old male with right lung mass, mediastinal, right neck, and supraclavicular lymphadenopathies. He was diagnosed with pulmonary pleomorphic carcinoma, cT4N3M1c, Stage IVB. The tumor cells showed high programmed death-ligand 1 (PD-L1) expression but no microsatellite instability. After three cycles of pembrolizumab as the first-line therapy, chest computed tomography revealed marked reduction in tumor diameter. No remarkable adverse events occurred. The patient is alive with no complaints and no disease progression and has continued pembrolizumab for 8 months. Thus, first-line pembrolizumab therapy appears beneficial against pulmonary pleomorphic carcinoma, at least when PD-L1 expression is high. It is also effective in elderly patients.
Fluorescent spectroscopic assessment before and after radiation treatment in oral cavity cancer and its clinical correlation
Authors: Akram Mohammad , Afrose Ruquiya , Katiyar R. K.
Published: December 2021

Background:

Biochemical changes in irradiated malignant tissue lead to altered autofluorophores status which should be different for cancerous tissue (residual/recurrence) and irradiated normal tissue. If this irradiated tissue is examined through fluorescent spectroscopy, we can find the spectroscopic changes occurring after the completion of treatment which can be helpful in evaluating treatment response.

Methods:

Punch biopsy sample was examined through fluorescent spectroscopy in oral cavity cancer patients before and after definitive radiation treatment. The change in spectroscopic pattern before and after radiation treatment was recorded and assessed.

Results:

Final analysis was done in 36 samples. In irradiated tissue, it has been observed that there was increase in the intensity of collagen fluorescence. It was found that the Half width half maximum (HWHM) is more in case of preirradiated sample. The decrease in the HWHM in case of irradiated sample shows the decrease in the number of cells (cell density as compared to that in preirradiated sample). These spectral findings are well-explained pathophysiologically and clinically as amount of collagen are increased in irradiated tissues due to loss of cancerous cells and regeneration of collagen cross-links (fibrosis) and reproduction of normal tissue as a response to radiation treatment.

Conclusion:

After thorough study in a large number of samples, we may be able in the future to grade the alteration in fluorescence of collagen obtained after radiation treatment in terms of complete, partial, or no response.
Management of IMRT in a gastric cancer patient with pacemaker
Authors: Ergen Sefika Arzu , Oksüz Didem Colpan , Karacam Songül , Dıncbas Fazilet Oner
Published: December 2021

Due to the prolongation of a lifetime, more cancer patients with cardiac implantable electronic devices are treated by radiotherapy. However, radiation may cause permanent or temporary malfunctions on these devices, and new-generation devices are more sensitive to radiation. Besides, radiotherapy techniques and image guidance methods that may cause different interactions with the functions of the devices have been changed significantly recently. Here, we reported our clinical experience in a patient with a pacemaker who underwent radiotherapy with intensity-modulated radiation therapy (IMRT) due to gastric cancer and reviewed the literature.
Effect of high-dose intravenous ascorbic acid on cancer patients following ketogenic diet
Authors: Sebastian Stelvin , Paul Aby , Joby Joel , Saijan Sanjo , Vilapurathu Jobin Kunjumon
Published: December 2021

Background:

The role of ascorbic acid in cancer therapy is mainly due to its structural similarity with glucose. When supplemented intravenously in high dose, ascorbic acid can get into the cancer cells and induce apoptosis by causing mitochondrial damage.

Aim:

The aim was to study the efficacy of high-dose intravenous (IV) ascorbic acid as monotherapy in cancer patients following ketogenic diet and its role in improving the quality of life.

Results:

C-reactive protein (CRP) and erythrocyte sedimentation rates (ESRs) were considered as parameters to determine the efficacy of the treatment, and substantial decrease in both the levels was observed within 1-week treatment. CRP levels declined from 3.1946 ± 3.2508 mg/L to 1.0606 ± 0.6706 mg/L (P = 2.27E-10), whereas ESR levels declined from 64.1333 ± 38.8253 mm/h to 31.6 ± 16.5520 mm/h (P = 0.0041). A decline in these parameters shows the association of ascorbic acid in reducing the inflammatory response in cancer. The renal effect of ascorbic acid was also studied by analyzing the creatinine level pre- and postascorbic acid treatment sessions, and it raised from 0.8526 ± 0.22904 to 1.1666 ± 0.2894 mg/dL (P = 1.18E-14). This showed the renal impact of ascorbic acid.

Conclusion:

The study highlighted the clinical benefit of IV ascorbic acid in the reduction of inflammatory response in cancer patients. The renal adverse events associated with ascorbic acid alarm the use with caution and therapeutic drug monitoring for ascorbic acid.
Active Surveillance of Adverse Events Following Coronavirus Disease 2019 Immunization in the Elderly Population
Authors: Tiwari Surya Pratap Singh , Anil Bhandari , Monika Rathore , Lokendra Sharma , Aditya Sharma , Smita Jain , Madhav Agarwal
Published: December 2021

Background:

Vaccine against coronavirus disease 2019 (COVID-19) was rolled out in India to prevent the infection caused by severe acute respiratory syndrome coronavirus 2. We aimed at investigating the adverse events following immunization (AEFI) associated with the first dose of Covishield (ChAdOx1 nCoV-19) vaccine in the elderly population (60 and above).

Methodology:

An observational study, conducted among 463 vaccinated individuals at multiple community health centers in Jaipur, of AEFIs associated with the first dose of Covishield vaccine. We investigated these AEFIs through telephonic interviews, using pharmacovigilance per forma provided from the Indian Pharmacopoeia Commission, Ghaziabad.

Results:

Four hundred and sixty-three people responded to the telephone survey. About 7.7% (36/463) of the respondents experienced AEFIs. Of these, commonly reported systemic AEFI were fever (47.2%), fatigue (38.8%), dizziness (5.5%), and diarrhea (2.7%), and local AEFI were injection site soreness (27.7%) and itching with rash (2.7%) AEFI reported in the age group (60–70) was higher (8.7%, 26/297) than those above 70 (6.2%, 10/166). Females (9.9%, 20/202) were associated with higher AEFI than males (6.1%, 16/261). More than one-third (43.8%, 203/463, P = 0.001) were hesitant before vaccination. Respondents in the age group of 60–70 years (55.2%, 164/297) were more hesitant than those above 70 (23.4%, 39/166). There is no association between gender and AEFI status and age group and respondent's AEFI.

Conclusion:

Only 7.7% of the respondents experienced AEFIs associated with ChAdOx1 nCoV-19, though all were mild and self-limiting. There were no serious events requiring hospitalization, and most AEFIs improved within few days. Vaccine hesitancy among 43.8% of the respondents could be attributed to the unscientific information on social media.
Cultural Competence Assessment in a Health-Care University
Authors: Balachandran Parvathy , Krishna Devika Maya , Janakiram Chandrashekar
Published: December 2021

Introduction:

Cultural competence of health-care professionals has a vital role in health-care system. The first step toward this orientation is the assessment of cultural competence level of clinical graduate students.

Objective:

The objective of the study was to assess the cultural competence of clinical graduate students of various courses in a health-care university, Kerala, India.

Methods:

A cross-sectional study was conducted among 398 clinical graduate students in a health-care university in Kerala, India. The self-administered questionnaire had 27 items adapted from various validated scales. Data analysis was done by the analysis of variance (ANOVA) using SPSS software (version 23). P < 0.05 was considered statistically significant.

Results:

The overall mean of the responses ranged from 2.81 (confidence interval [CI]: 2.70–2.93) to 4.50 (CI: 4.43–4.57). ANOVA revealed statistically significant differences between the courses in competencies related to specific competencies.

Conclusion:

Our findings suggest that cultural competence of health-care graduates can be improved by incorporating cultural competence training in the curriculum.
Relationship between Emotional Intelligence and Aggression Among Nursing Students in a Tertiary Institute
Authors: Gijwani Deeksha , Mathur Anmol , Batra Manu , Sharma Aditi
Published: December 2021

Background:

Working with emotions is an important aspect of the nurse–patient relationship: the nurse will better manage his/her own emotions, and will also influence patient's emotions on investigations, treatments, fears, vision about disease, etc., Aggression is one of the important factors that significantly affect the performance of an individual.

Aim:

The aim of this study was to identify the level of emotional intelligence (EI) and aggression among nursing students and to assess its correlations with sociodemographic variables.

Materials and Methods:

A cross sectional study was done among 242 nursing students of various nursing colleges of Sri Ganganagar, Rajasthan. Data collection was done using two questionnaires one for emotional intelligence and another for aggression level. The results were determined using the mean, standard deviation, T test and Pearson's correlation coefficient with level of significance was set at P < 0.05.

Results:

There is a nonsignificant negative relationship of verbal aggression (r = −0.0192) with EI. Higher aggression was seen in male participants in the age group of 18–21 years and in the 1st year of nursing students (P ≤ 0.01).

Conclusion:

Males were more aggressive whereas females were found to be more emotionally intelligent in the current study.
Estimation of Fluoride Level in Drinking Water Samples of Raipur District, Chhattisgarh
Authors: Jain Anubhuti , Parakh Abhinav , Yunus G. Y. , Naveen N. , Jain Kamlesh Kumar , Agrawal Ruchi
Published: December 2021

Background:

The fluoride intake in the general population derives chiefly from drinking water and dietary sources. The presence of fluoride in groundwater for drinking purposes may be beneficial or detrimental depending on its concentration and the amount ingested.

Objective:

The objective of the study was to estimate the concentration of fluoride in drinking water sources of Raipur district.

Methodology:

A descriptive cross-sectional study was carried out for fluoride mapping of Raipur district. Samples of drinking water were collected from 50 different sites of 20 villages. The concentration of fluoride in drinking water was analyzed using ion-selective electrode method.

Results:

In all the water samples analyzed, there was the presence of trace amount of fluoride, which ranged from 0.2 ± 1.22 ppm with the mean concentration of 0.411 ± 0.180 ppm.

Conclusion:

Fluoride levels in groundwater were in trace quantity and well below the optimal level of fluoride necessary for caries prevention.
Qualitative and Quantitative Evaluation of Bacterial Contamination of Toothbrushes Kept in Different Sanitary Settings
Authors: Thakur Meenakshi , Mittal Sudhir , Sharma Amit Kumar , Sharma Devender Kumar , Gupta Kamal K , Pathania Vasundhara
Published: December 2021

Background:

Oral health is an integral part of general health and toothbrushes are the most commonly used oral hygiene aid. Unfortunately, proper care of toothbrush is often neglected and is kept in bathrooms which are a good place to harbor millions of microorganisms.

Aim:

To assess the bacterial contamination of toothbrushes for Streptococcus mutans, Staphylococcus aureus, Candida albicans, and Lactobacillus when kept in different sanitary settings before and after the use of disinfectant.

Materials and Methods:

A total of 60 volunteers were randomly selected between the age of 6–16 years. Toothbrushes were grouped into two categories: Group 1: Outside the bathroom. Group 2: Within the bathroom with attached toilet. Group 2 was further divided into two subgroups: Group 2 (i): Kept individually in separate containers. Group 2 (ii) kept with that of family members and siblings within the same container. The present study was carried for 3 months in two phases with the same participants both before and after the use of disinfectant.

Results:

Microbial contamination was highest in Streptococcus and least in Lactobacillus before and after the use of disinfectant when toothbrushes were kept outside the bathroom and microbial contamination was similar in both Streptococcus and Lacctobacilus when kept inside the bathroom with attached toilet in separate container and same container both before and after the use of disinfectant.

Conclusion:

A high level of pathogenic microorganisms were seen in toothbrushes kept in the bathroom for 3 months which were reduced by dipping them in 0.12-% chlorhexidine gluconate.
Unusual Case of Follicular Lymphoma Presenting as Solitary Painless Scalp Swelling
Authors: Sharma Rahul , Katkar Anand , Bhanage Ashok
Published: December 2021

Follicular lymphoma (FL) is the second most frequent non-Hodgkin lymphoma accounting for about 10%–20% of all lymphomas. FL usually presented with peripheral adenopathy involving cervical, inguinal, and femoral regions. FL presenting as a scalp swelling without involvement of underlying cerebral parenchyma or systemic manifestation in a nonimmunocompromised patient is an extremely rare medical condition requiring aggressive treatment and neurosurgical intervention. We report the case of a 33-year-old male presenting with progressively increasing painless large left-sided frontal scalp swelling. The patient underwent near-total excision of lesion. Histopathology report suggested FL. We report this case for discussion regarding pathophysiology, diagnosis, and appropriate clinical management.
On digits of Mersenne numbers
Authors: Kerr Bryce , Mérai László , Shparlinski Igor E.
Published: December 2021

Motivated by recently developed interest to the distribution of

q

-ary digits of Mersenne numbers

M_p = 2^p-1

, where

p

is prime, we estimate rational exponential sums with

M_p

,

p \le X

, modulo a large power of a fixed odd prime

q

. In turn this immediately implies the normality of strings of

q

-ary digits amongst about

(\log X)^{3/2+o(1)}

rightmost digits of

M_p

,

p \le X

. Previous results imply this only for about

(\log X)^{1+o(1)}

rightmost digits.
‘Event-tualising’ Physical Leisure Activity: How Gauteng Parkrunners Brought the Parkrun Home during COVID-19
Authors: de Vries Leani , Gunter Ashley
Published: December 2021

On the 27th of March 2020, South Africa entered hard lockdown (alert level 5) following the outbreak of the COVID-19 pandemic, with the banning of all physical activity outside a place of residence. As a result, official parkrun events were immediately suspended. In June 2020, the country moved to alert level 3, no longer curbing the use of public spaces for leisure, entertainment, and physical activity, albeit with restrictions. However, group sports leisure, such as parkruns remained prohibited. Thus, parkrun, a highly successful global movement where individuals gather on Saturday mornings for a timed 2 or 5km run, jog, or walk, with family and friends, was severely affected by COVID-19 prevention measures. In mitigation, parkrun officials launched, in June 2020, the (not)parkrun to enable individuals to log (on the parkrun website) their own 5km activity, irrespective of time, day or route. In this regard, parkrun enabled parkrunners to bring the event ‘home’, that is, to informally claim public space and time for their physical leisure. By analysing participation figures and feedback posted on the national parkrun blog and social media pages, this research shows how the (not)parkrun enabled Gauteng parkrunners to ‘event-tualise’ their runs to counter act the de-eventualisation of the parkrun by lockdown regulations.
PARA UMA DOENÇA TÃO ANTIGA, O VISLUMBRE DE NOVOS TRATAMENTOS PROMISSORES NA DOENÇA DE CHAGAS
Authors:   Centro Universitário Barão de Mauá, Ribeirão Preto, SP, Brasil., Hilgert Sabrina Sehn , Lima Sofia Comássio de Paula ,   Centro Universitário Barão de Mauá, Ribeirão Preto, SP, Brasil., Salviano Sofia Ferreira ,   Centro Universitário Barão de Mauá, Ribeirão Preto, SP, Brasil., Tefé-Silva Cristiane ,   Centro Universitário Barão de Mauá, Ribeirão Preto, SP, Brasil.
Published: December 2021

It has been more than 100 years since the discovery of Chagas Disease (CD). However, the repertoire indicated for its treatment is still limited. Thus, this article aims to present a review of the new pharmacological strategies being studied for CD. This literature review, consisting of 68 articles, from 1957 to 2021, was carried out on several scientific platforms. Positive effects from benznidazole have been described in the acute and chronic phases, in addition to its association with itraconazole in the acute phase. Among the cruzain inhibitors, the compound K777 presented trypanocidal effects, although demonstrating major adverse effects, while its analogue WRR-483 demonstrated great beneficial effects in vivo and in vitro. As for the nitroheterocyclics, fexinidazole showed high rates of cure in animal model, in addition to low toxicity. Nifurtimox, in early chronic stages, was able to delay the progression of tissue damage and reduce the parasite load. The compound WC-9, a squalene synthase inhibitor, showed potential inhibition of T. cruzi replication. Regarding aromatic diamidines, many compounds were able to stop the trypanosome, both in vitro and in vivo models. It was concluded that there are favorable findings to improve the treatment of CD. However, the development of effective new drugs does not only depend on their effective action, but also on numerous variables that must be circumvented, such as the reduction of side effects, treatment time and adherence to the current medication of choice, as well as the investment in production and distribution to the population.
Mengembangkan Etika Sosial Antara Siswa dengan Guru dalam Pembelajaran Pendidikan Agama Kristen Sistem Daring
Authors: Siallagan Thomson
Published: December 2021

Abstrak

Di masa pandemi 19, sistem pembelajaran tatap muka berubah menjadi sistem pembelajaran jarak jauh. Anak belajar dari rumah dan guru mengajar dengan menggunakan jaringan internet. Berbagai persoalan muncul dalam sistem pembelajaran online ini, termasuk masalah etika sosial antara siswa dengan guru. Penelitian ini bertujuan untuk mengkaji bagaimana mengembangkan etika sosial antara siswa dengan guru dalam pembelajaran online di masa pandemi. Metode penelitian yang digunakan adalah metode kajian pustaka dengan menggunakan literatur-literatur yang berkaitan dengan subjek kajian. Hasil yang kajianj ditemukan dalam megembangkan etika sosial anatar siswa dengan gur dalam pembelajaran online di masa pandemi adalah sebagai berikut: mengembangkan etika sosial antara siswa dengan guru dalam pembelajaran secara partisipatif. Guru khususnya guru BP mensosialisasikan etiak sosial tersebt secara berulang-ulang dengan sistem kolaboratif, yakni melibatkan semua stakeholder pendidikan, termasuk orang tua dan komite sekolah. Guru bersikap lembut tapi tegas dalam menjalankan etika sosial tersebut. Guru mengatasi siswa yang kurang beretika dengan bijaksana dan di lain pihak guru bersikap profesional dan menjadi teladan beretika sosial dalam pembelajaran.
Roles de género y la identidad de las mujeres chicanas/ latinas en Loverboys de Ana Castillo
Authors: Merino Aguilera María de la O
Published: December 2021

Ana Castillo (Chicago, 1953) es la autora de la colección de relatos Loverboys (1996). Estos relatos abordan la realidad de las mujeres chicanas y latinas en los EE. UU. a partir de una pluralidad de contextos sociales. El propósito de este artículo es analizar los relatos de Loverboys, desde la perspectiva de los roles de género y el concepto de identidad, así como presentar una breve observación inicial sobre cómo las voces femeninas han sido silenciadas a lo largo de la historia. La hipótesis que se desea demostrar es que Castillo defiende, conserva y pretende restaurar en estos relatos los valores de las mujeres chicanas y latinas, repetidamente denostados por el machismo de la sociedad patriarcal, a través de los personajes femeninos de los relatos recogidos en Loverboys.
Apendicite aguda puerperal: Relato de caso
Authors: Novo Joe Luiz Vieira Garcia , Chen Christiane Machado
Published: December 2021

A apendicite aguda é a causa cirúrgica não obstétrica mais comum no ciclo grávido puerperal, incluindo as puérperas. O atraso no diagnóstico em virtude de a sua sintomatologia apresentar-se geralmente atenuada ou ausente, ou por ser confundida com alterações fisiológicas do puerpério, poderá ocasionar aumento de duas a três vezes a perfuração apendicular, peritonite puerperal, resultando em alguns casos em mortalidade materna. Relata-se um caso de apendicite aguda puerperal ulcero-necrotizante e a sua evolução pós-operatória. O aumento de duas a três vezes na presença de perfuração do apêndice e peritonite nas puérperas, podendo resultar grave morbidade e/ou mortalidade, ressaltam a importância da divulgação da frequência de casos de apendicite aguda em puérperas entre clínicos e obstetras. É de suma importância que estejam atentos em relação a sua ocorrência, e assim possam realizar o diagnóstico o mais precocemente possível, visando a redução do número de complicações e da mortalidade destas pacientes.
Unintended Authors: Piracy, Plagiarism and Property in Victorian Popular Culture
Authors: Cohen Monica
Published: December 2021

The introduction to this special issue of the Victorian Popular Fictions Journal, “Unintended Authors,” argues that Victorian popular fictions crucially relied on incoherently regulated global artistic markets that made bargain-basement grabbing and reselling comme il faut. The absence of clear and uniform copyright statutes, case law, and trade practices across national, colonial, linguistic, and generic borders surprisingly did not obstruct nineteenth-century authorship; rather these conditions did the work of cultivating an extraordinary proliferation of scrappy innovators creatively reusing antecedents. A cast of rogue publishers, theatrical adaptors, and proto brand managers take centre stage here in an effort to recognize the collaborative, appropriative, and reiterative dimensions of nineteenth-century fictional entertainment.
“A Nondescript Monster”: Fanny Fern in Transatlantic Print Culture
Authors: Alhammad Mashael
Published: December 2021

Fanny Fern (real name Sara Payson Willis Parton) was one of the most profitable American columnists and novelists of the mid-nineteenth century. Fern sustained her celebrity status largely through unauthorised reprints of her articles in American and British papers. Consequently, her public image was for the most part constructed through those reprinted articles, which were usually framed by speculations about her private life. This article examines the implications and limitations of Fern’s efforts to stabilise the dissemination of her public image in periodicals by using the relatively more stable form of the book. As a celebrity, she had limited control over the way she was publicly represented. As a woman in the public sphere, she was particularly vulnerable to slander and libel. The circulation of a spurious biography entitled The Life and Beauties of Fanny Fern (1855), alongside her sanctioned autobiographical novel Ruth Hall, profited from her literary brand while simultaneously undermining it. Examining how these competing narratives about Fern’s private life – one fictionalised, one unauthorised – shaped her literary reputation at home and in England, this paper argues that textual representations as well as material market choices, including book bindings and advertising techniques, shaped authorship in the increasingly commercialised transatlantic literary market of the mid-century in ways that both benefited and imperilled the female writer.
Class and Complex Transmedia Character in the Early Victorian Period: Jack Sheppard (1839-40)
Authors: Haugtvedt Erica
Published: December 2021

The reception of William Harrison Ainsworth’s novel, Jack Sheppard (1839-1840), was contemporaneously deemed a mania and has been described by critics today as a moral panic over the influence of fiction. Several adaptations of Ainsworth’s novel across media ambiguously depict Jack’s hanging, and the adaptations that most clearly show his survival occur in those versions that are least legally defensible and most clearly targeted toward the labouring classes. In this essay, I analyse Buckstone and Greenwood’s melodramas at the Adelphi and Sadler’s Wells, respectively, in autumn 1839; two penny press novelisations of Jack Sheppard published in 1839 and 1840; and an anonymous melodrama staged at the City of London Theatre in 1845, which was shut down due to violating the licensing ban on Jack Sheppard titles. From contemporary accounts of the mania, I argue that audience members treated historical and fictional accounts of Jack as describing the same entity, which created the space for specifying new facts and thus claiming new meaning. I therefore see Jack Sheppard as a transmedia character. For the labouring classes, claiming new meaning sometimes inhered in Jack’s defiance of capital punishment. This transmedial extension of Ainsworth’s character by working-class audiences in the penny press and cheap theatre pointed to the inadequacies of Victorian copyright law to protect the creative property of originating authors across media, and thus disturbed Victorian middle and upper-class literary critics because they saw the lower class’s celebration of a criminal as threatening to undermine their social order. Using the concept of transmedia in this period allows us to see how enthusiastic audience members in the working classes created what I term character complexity as they built a palimpsest out of the panoply of cross-media character representations. This transmedia character complexity matters because it is an avenue for oppressed communities to reclaim their dignity through narrative meaning-making.
PERENCANAAN STRATEGIS SISTEM INFORMASI DI SINODE GKJ SALATIGA DENGAN KERANGKA WARD AND PEPPARD
Authors: Ariyanto Inneke Zefania , Nataliani Yessica , Sitokdana Melkior N. N.
Published: December 2021

Penerapan teknologi informasi yang mencakup sistem informasi di Sinode GKJ (Gereja Kristen Jawa) Salatiga hingga sekarang belum sepenuhnya diterapkan dalam organisasi. Untuk itu perlu dilakukan perencanaan guna membangun perencanaan strategis SI beserta portofolio aplikasi Sinode GKJ Salatiga. Upaya ini dapat memberikan kontribusi yang optimal dan terintegrasi, sehingga dapat menyatukan seluruh aspek pendukung dan merealisasikannya dalam tujuan bisnis. Kerangka Ward and Peppard digunakan untuk perencanaan Strategis SI dalam kerangka kerja. Untuk pemetaan seluruh proses bisnis digunakan analisis Value Chain, sedangkan SWOT Analysis digunakan untuk mengevaluasi kekuatan, kelemahan, peluang, dan ancaman lingkungan eksternal dan internal. Dalam menyusun portofolio SI dan TI berdasarkan hasil analisis serta kajian terhadap aktivitas utama dan pendukung yaitu dengan menggunakan McFarlan Strategic Grid. McFarlan Analysis digunakan untuk pemetaan aplikasi saat ini dan juga kebutuhan aplikasi di masa mendatang untuk memperlancar jalannya proses bisnis. Hasil dari perencanaan strategis sistem informasi ini berupa rekomendasi sistem informasi untuk mendukung kegiatan organisasi, yang meliputi peningkatan aplikasi penjualan buku dan homepage, disertai perbaikan infrastruktur jaringan, penambahan keamanan aplikasi, restrukturisasi jaringan internet, pembentukan SOP dan struktur organisasi.
ANALISA KELAYAKAN INVESTASI SPBU MIKROSITE INDOMOBIL DI DESA GRAJAGAN
Authors: Bhakti Hendra , Setiawan Bela Iwari , Soeroto Wisudanto Mas
Published: December 2021

Semakin meningkatnya pertumbuhan ekonomi di Indonesia menyebabkan tingginya angka kepemilikan kendaraan oleh masyarakat. Hal ini didukung dengan masih berjalannya penjualan kendaraan bermotor dalam bentuk sepeda ataupun mobil sesuai data penjualan dari Gabungan Industri Kendaraan Bermotor Indonesia Tahun 2021. Berdasarkan kondisi tersebut, juga berpengaruh pada konsumsi bahan bakar (BBM) kendaraan bermotor. BBM seakan benar-benar menjadi kebutuhan primer setara dengan sandang, pangan dan papan yang sangat dicari oleh masyarakat. Namun demikian, hal tersebut belum didukung dengan fasilitas penjualan atau biasa disebut Satuan Pengisian Bahan Bakar Umum (SPBU) yang merata dan memadai seperti di Banyuwangi. Menindaklanjuti kondisi tersebut CV Ameera Jaya sebagai perusahaan start up melihat potensi pembangunan SPBU mikrosite sebagai prospek dalam berinvestasi. Tujuan dilakukannya penelitian ini sebagai analisis kelayakan bisnis untuk menunjang kelangsungan investasi. Dalam melakukan penelitian dilakukan pengambilan data dengan metode observasi dan wawancara serta mempelajari data menggunakan aspek hukum, aspek lingkungan, aspek pasar dan pemasaran, aspek teknis dan teknologi, aspek manajemen dan sumber daya manusia, serta aspek keuangan, Secara aspek hukum, investasi Microsite Grajagan layak dilakukan karena telah memenuhi persyaratan-persyaratan yang dibutuhkan. Secara aspek pasar dan pemasaran, investasi tersebut layak untuk dijalankan dengan estimasi omzet tahun pertama 99.180 liter atau Rp. 1.071.144.000,-. Secara aspek keuangan, payback period tercapai pada tahun ke 2 dan 9 bulan 14 hari serta Net Present Value (NPV) sebesar Rp. 494.831.444 dimana hal tersebut sudah layak untuk dilaksanakan karena maksimal payback period adalah 5 tahun dan NPV > 1.
POTENSI LIKUIFAKSI DI PESISIR BARAT SUMATERA MENGGUNAKAN SONDIR
Authors: Mutmainah Herdiana
Published: December 2021

Peristiwa gempa umumnya diikuti oleh serangkaian guncangan dan sesar tanah di permukaan. Gempa rawan terjadi pada lokasi yang dilalui jalur patahan dan tumbukan lempeng tektonik aktif. Pantai barat Sumatera berada di jalur patahan Semangko dan perbatasan lempeng tektonik aktif Eurasia dan Australia-Hindia. Gempa di atas skala 5,5 SR memicu likuifaksi pada tanah granuler dan muka air tanah dangkal. Kabupaten Agam dan Kabupaten Pasaman Barat di pesisir barat Provinsi Sumatera Barat merupakan lokasi yang rawan likuifaksi. Gempa Padang pada tahun 2009 (7,9 SR) berdampak memicu likuifaksi di kedua kabupaten tersebut. Penelitian ini bertujuan untuk menganalisa potensi likuifaksi di Kabupaten Agam dan Kabupaten Pasaman Barat. Penelitian dilakukan pada Oktober 2019 berdasarkan metode faktor aman menggunakan sondir (Cone Penetration Test/CPT) di 3 (tiga) desa yaitu Desa Tiku (Kabupaten Agam), Desa Air Bangis dan Desa Sasak (Kabupaten Pasaman Barat). Hasil penelitian menunjukkan Gempa 7 SR sudah mampu memicu likuifaksi (SF<1,0) di Desa Air Bangis dan Desa Sasak sedangkan simulasi Gempa Padang tahun 2009 (7,9 SR) menunjukkan potensi likuifaksi di Desa Tiku adalah SF = 0,53 – 0,95; Desa Air Bangis SF = 0,51 – 0,97 dan Desa Sasak SF = 0,45 – 0,95.
PENGEMBANGAN VIDEO PEMBELAJARAN MATEMATIKA BERORIENTASI KEBUDAYAAN LOKAL PADA SEKOLAH DASAR
Authors: Sadewo Yosua Damas , Purnasari Pebria Dheni
Published: December 2021

Fokus Penelitian dalam penelitian pengembangan ini adalah menghasilkan produk Video Pembelajaran Matematika Berorientasi Kebudayaan Lokal yang sesuai kebutuhan dan mempunyai karakteristik yang praktis yang dapat dengan mudah digunakan oleh guru dan siswa SDN 02 Bengkayang. Penelitian ini dikategorikan dalam jenis penelitian pengembangan (research and development), yaitu pengembangan Video Pembelajaran Matematika Berorientasi Kebudayaan Lokal yang berorientasi pada model pengembangan Borg and Gall dan ADDIE. Lokasi penelitian ini adalah SDN 2 Bengkayang dengan subjek penelitian siswa kelas 1 SDN 2 Bengkayang, beserta guru kelas, dan orang tua siswa. Instrumen yang digunakan terdiri dari lembar observasi, lembar uji pakar, catatan penelitian, dan dokumentasi. Teknik analisis data dalam penelitian ini menggunakan teknik kuantitatif deskriptif yakni dengan menganalisis hasil uji pakar, dan lembar observasi. Hasil dalam penelitian ini adalah secara garis besar video pembelajaran yang dikembangkan telah berada pada kategori valid dan layak untuk diimplementasikan. Hal ini ditunjukkan dengan hasil penilaian uji pakar yang mendapat nilai rata-rata 41,67 di mana kategori dari nilai tersebut adalah baik. Pengukuran karakteristik video dilakukan dengan menggunakan lembar observasi dengan nilai rata-rata sebesar 77,2 dengan kategori baik. Persentase dari penilaian lembar observasi menunjukkan nilai sebesar 46,43% siswa memberikan respond yang sangat baik, 17,86% siswa memberikan respond yang baik, dan 35,71% siswa memberikan respond cukup. Hasil ini mengindikasikan bahwa video pembelajaran yang dikembangkan memiliki karakteristik yakni mudah dipahami siswa, menarik minat dan antusiasme siswa dalam pembelajaran, serta dapat membantu siswa saat belajar di rumah.
EFEKTIVITAS PENERAPAN MEDIA PEMBELAJARAN DARING PADA PEMBELAJARAN TEMATIK SEKOLAH DASAR NEGERI 02 BENGKAYANG
Authors: Silvester Silvester , Purnasari Pebria Dheni , Sumarni Margaretha Lidya
Published: December 2021

Tujuan penelitian ini untuk mendeskripsikan efektivitas penerapan media pembelajaran daring serta kendala dan faktor yang dihadapi guru dan peserta didik dalam menerapkan media pembelajaran daring pada pembelajaran tematik di Sekolah Dasar. Metode yang digunakan dalam penelitian ini yaitu metode deskriptif dengan pendekatan kualitatif. Teknik pengumpulan data dalam penelitian ini dengan menggunakan observasi, wawancara dan dokumentasi. Analisis data menggunakan analisis data yang dikembangkan oleh Miles dan Huberman yaitu reduction, data display, dan conclusion drawing. Keabsahan data dalam penelitian ini yaitu dengan menggunakan teknik triangulasi. Berdasarkan hasil penelitian yang dilakukan di SDN 02 Bengkayang ditemukan bahwa pembelajaran tematik dengan menerapkan media pembelajaran daring belum efektif, dikarenakan berbagai kendala dan faktor yang mempengaruhi diterapkannya media pembelajaran daring dalam proses belajar mengajar. Berdasarkan hasil observasi dan wawancara yang dilakukan bersama guru dan peserta didik di SDN 02 Bengkayang ditemukan bahwa dalam proses pembelajaran tematik guru belum menggunakan media pembelajaran daring yang menarik dan sesuai dengan materi pembelajaran, sehingga peserta didik tidak mampu memahami pembelajaran yang diberikan oleh guru secara utuh. Selain itu peserta didik tidak memiliki sarana penunjang seperti smartphone pribadi untuk mengikuti pembelajaran yang menerapkan media pembelajaran daring hal ini membuat peserta didik menggunakan smartphone milik orang tua nya, jaringan internet yang kurang memadai dan kondisi ekonomi keluarga peserta didik berada di tingkat menengah sehingga peserta didik tidak mampu membeli kuota/data internet untuk menunjang proses belajar mengajar yang menerapkan media pembelajaran daring. Guru sebaiknya mengikuti pelatihan mengenai berbagai media pembelajaran berbasis teknologi atau media pembelajaran daring sehingga dapat merancang dan mengelola pembelajaran daring dengan baik dan efektif sesuai dengan perkembangan zaman.
PERANCANGAN SISTEM INFORMASI LOGISTIK DAN PERGUDANGAN DI YAYASAN DHARMA BHAKTI BERAU COAL
Authors: Asrory Fahriza Fawwas , Safitriani Dewi
Published: December 2021

Yayasan Dharma Bhakti Berau Coal (YDBBC) menghadapi permasalahan pada sistem logistik mulai dari penanganan gabah dari petani kemudian masuk proses pengolahan sampai menjadi padi. Sistem input data yang dilakukan saat ini belum berjalan dengan baik. YDBBC masih menggunakan cara manual dalam proses administrasi pergudangan nya di mana penggunaan teknologi informasi masing sangat kurang. Kondisi ini cukup menyulitkan YDBBC dalam hal pengaksesan informasi administrasi pergudangan. Aliran informasi yang dilakukan secara manual ini menimbulkan dampak bagi yayasan seperti data tercecer, kesalahan dalam penginputan administrasi serta terhambat nya proses produksi. Melihat kondisi tersebut maka perlu perbaikan terhadap sistem logistik dan pergudangan yang sedang berjalan dan kemudian memberikan rancangan sistem infomasi logistik dan pergudangan kepada YDBBC untuk mempermudah proses pengelolaannya. Penelitian ini bertujuan untuk memberikan rancangan sistem informasi logistik dan pergudangan YDBBC agar proses penginputan data dapat mudah digunakan oleh user di gudang. Metode yang digunakan pada penelitian ini adalah metode System Development Life Cycle (SDLC). Dalam perencanaan System Development Life Cycle (SDLC) dimulai dengan menentukan dan mendefinisikan sistem informasi, selanjutnya data di analisis, kemudian di desain atau dirancang sesuai dengan sistem informasi yang ada. Hasil rancangan kemudian diimplementasikan, di uji dan hasilnya akan digunakan oleh user. Kelebihan dari hasil perancangan sistem logistik ini adalah mempermudah administrasi data dan pengelolaan data. Penerapan rancangan sistem informasi pergudangan dan logistik di gudang YDBBC terbukti dapat memudahkan karyawan dalam proses pengelolaan data gudang mulai dari beras masuk ke gudang, pengelolaan stok gudang, sampai pengelolaan data pemesan/konsumen beras dari gudang.
TIC aplicada a la generación de conocimientos comunicativos en universitarios para el desarrollo del emprendedurismo
Authors: Soto Hidalgo Cinthya Virginia , Hidalgo Puell Teodelinda Rosa , Panduro Ramírez Jeidy Gisell , Alanya Beltrán Joel Elvys
Published: December 2021

El uso de nuevas tecnologías como plataformas virtuales, ya sea para estudio o negocio; aplicaciones para celular, formatos de archivos comprimidos, almacenamiento gratuito y mensajería instantánea; son solo un complemento del estilo de vida de cada joven estudiante de hoy. Sin embargo, para los docentes es un reto, no solo porque son herramientas indispensables para el aprendizaje de nuevos conocimientos y tienen que adaptarse a ellas; sino porque estas últimas generaciones demuestran un desapego y desinterés en las relaciones humanas, forzando la creación y aplicación de nuevas estrategias comunicativas, que rescaten la relación entre docente y alumno. El objetivo de este artículo es mostrar los resultados de un programa que busca estimular el espíritu emprendedor desde la universidad, a fin de potenciar el talento y la creatividad necesaria para la competitividad en un mundo laboral globalizado. Dentro de las conclusiones resaltan, la empatía innata que tienen los estudiantes con el uso de herramientas tecnológicas y el ímpetu que debe desarrollar el docente para concientizar en los alumnos la perseverancia y resiliencia que lo ayudará a superar obstáculos y fortalecerá toda idea de negocio que emprenda.

Abstract.

 

The use of new technologies such as virtual platforms, wheter they are used to study or for business; cellphone applications, compressed-file formats, free storage, instant messaging are only complements to a young  student's lifestyle. Nevertheless, for teachers it is a challenge, not only because they have to adapt to them. Due to the fact that these generations demonstrate detachment and a lack of interest in human relations, the development and application of new communicative strategies that rescue the relationship between teacher and student are needed. The objective of this article is to show the results of a program that seeks to stimulate their entrepreneurial spirit while they are still in university, thus enhancing talent and creativity necessary to compete in a globalized labor market . Within our conclusions emphasis is given to the innate emphaty that students demonstrate with the use of technological tools and the impetus that teachers should develop to increase student's awareness of perseverance and resilience that will allow them to overcome obstacles and strengthen every entrepreneurial idea they have undertaken.
The Inequality Machine
Authors: Peeters Rik , Nieto-Morales Fernando
Published: December 2021

Access to rights depends on the institutional capacity to deliver and citizens’ capacity to benefit from public services and programmes. This is where bureaucracy and inequality meet: many times, even if access procedures are designed for equality, they do not produce equal results. Bureaucratic pathologies, deficits, and administrative burdens imply that different citizens might not share the same experience while interacting with government agencies. Moreover, in some developing countries like Mexico, inequality in access leads to the creation and reinforcement of "low-trust” bureaucracies. This paper offers some general ideas on this problem and stresses the relevance of understanding bureaucratic dysfunction from the citizens' point of view particularly in weak institutional contexts.
Basic principles of descriptive statistics in medical research
Authors: Bulanov N. M. , Suvorov A. Yu. , Blyuss O. B. , Munblit D. B. , Butnaru D. V. , Nadinskaia M. Yu. , Zaikin A. A.
Published: December 2021

Descriptive statistics provides tools to explore, summarize and illustrate the research data. In this tutorial we discuss two main types of data - qualitative and quantitative variables, and the most common approaches to characterize data distribution numerically and graphically. This article presents two important sets of parameters - measures of the central tendency (mean, median and mode) and variation (standard deviation, quantiles) and suggests the most suitable conditions for their application. We explain the difference between the general population and random samples, that are usually analyzed in studies. The parameters which characterize the sample (for example, measures of the central tendency) are point estimates, that can differ from the respective parameters of the general population. We introduce the concept of confidence interval - the range of values, which likely includes the true value of the parameter for the general population. All concepts and definitions are illustrated with examples, which simulate the research data.