bluuebunny/crossref_metadata_2025 huggingface dataset:
EL TERCERO CONSTITUCIONAL A DEBATE
Authors: Aguilar María , Aguiñaga Eduardo , Barba Jose , Bautista Luis , Becerra Emigdio , Bossi Cecilia , Benavides Mario , Bracho Teresa , Bravo Manuel , Cabrera Dulce , Calderon David , Carbajal Jose , Carmona Nancy , Ceron Juan , Chavez Yedidi , Collí Victor , Conde Francisco , Cortés Graciela , Díaz Magdalena , Flores Vicente , Gómez Lorenzo , González José , Hernández Marina , Hernandez Luisa , Hernández Martha , Hernández Guillermo , Hernández Nancy , Islas Juana , Lavín Jorge , Leo Leyla , Marín Álvaro , Mendezcarlo Violeta , Miranda Francisco , Molina Carlos , Ortiz Alejandro , Peredo Maria , Pérez Francisco , Pons Leticia , Reyes Mauricio , Rosalió Antonio , Romero Rosalina , Sosa Luis , Tovar Yvonne , Trujillo Jesus , Valdez Daniel , Valdéz Gloria , Vértiz Miguel , Villamil Erica
Published: February 2023

Educación laica, gratuita, obligatoria, integral, científica, democrática, nacionalista y de calidad, como valores para la educación pública que se han incorporado y evolucionado a través del tiempo, han dado sentido y orientación a la acción gubernamental durante gran parte del siglo que ha cumplido la Constitución mexicana de 1917; sin embargo, parecen aún lejanos e insuficientes para configurar el proyecto educativo del México futuro. Por ello, el debate sobre el derecho a la educación, si bien tiene varias décadas de estar presente entre especialistas y académicos, parece más pertinente hoy, frente a las dificultades y controversias que ha enfrentado la reforma educativa de 2013. El centenario del Artículo Tercero Constitucional es un marco simbólico que brinda la oportunidad de compendiar el estado actual de su debate, mismo que se ha logrado gracias a la colaboración entre la Universidad Pedagógica Nacional, la Facultad Latinoamericana de Ciencias Sociales-México (flacso) y la Comisión de Educación del Senado de la República lxiii Legislatura, que además abre la posibilidad para la reflexión permanente sobre los retos que deberá enfrentar, en los años venideros, este importante derecho humano. Para hacer un justo reflejo del debate nacional, la pluralidad se planteó como uno de los principales objetivos de esta obra. Las contribuciones que se encuentran incluidas fueron desarrolladas por sus autores, en respuesta a una convocatoria de la Universidad Pedagógica Nacional y la Comisión de Educación del Senado de la República lxiii Legislatura, buscando que todo interesado en el tema que tuviera algo que aportar al debate pudiese hacerlo, siempre en un marco de tolerancia al derecho de otros de disentir, condición que los autores participantes mostraron en un elevado ejemplo de capacidad de diálogo y debate entre pares, donde las posturas totalizantes cedieron el paso a la crítica reflexiva.
La eficiencia de las universidades públicas estatales e interculturales en México
Authors: Delfín Ortega Odette Virginia , Zacarías Paz Juan
Published: February 2023

En este trabajo de investigación se realizó la evaluación de eficiencia de 41 Instituciones de Educación Superior(IES) de México, de las cuales 31 son Universidades Públicas Estatales (UPES) y 10 UniversidadesInterculturales (UI) en el año 2014 y 2018, mediante la metodología de Análisis Envolvente de Datos (DEA) conrendimientos variables a escala (VRS) y orientación output, se realizó además un análisis benchmarking y unanálisis de holguras. Para darle robustez a los resultados se instrumentó la técnica boostrap y para la selección delas variables se utilizó el coeficiente de correlación de Pearson con el cual, después de aplicarlo, los inputs quequedaron en el modelo fueron matrícula, docentes, programas académicos, profesores en el SNI y subsidio y losoutputs alumnos titulados, convenios y programas acreditados. De acuerdo con los resultados obtenidos, seobservó que las DMU presentan una ineficiencia en el año 2014 de 38% y en el año 2018 de 33%, lo que reeja undesempeño aceptable de las mismas.
THE EFFECTS OF SOCIOSCIENTIFIC ISSUES APPROACH WITH THINKING WHEEL MAPS ON ENTREPRENEURIAL SCIENCE THINKING AMONG FIFTH GRADERS
Authors: Siew Nyet Moi , Ahmad Jamilah
Published: February 2023

This research was conducted to examine the effects of the socioscientific issue approach (SSI) with thinking wheel map (TM) on entrepreneurial science thinking (EST) and the constructs of Observation, New Ideas, Innovation, Creativity, and Value. A teaching and learning (TL) module was developed to guide teachers in implementing the infusion of SSI with TM TL approach on EST among fifth graders. Quasi-experimental quantitative research was conducted on 345 fifth graders in urban primary schools in Malaysia. A total of three TL groups were assigned randomly; namely, i) SSI-TM approach (n=115), ii) SSI (n=115) and iii) Conventional approach (CONV, n=115). The results of the MANCOVA analysis showed a significant effect across the three groups of TL approach for EST. Meanwhile, the ANCOVA analysis results showed a significant effect of the SSI-TM TL approach compared to SSI and CONV on EST and in all constructs of EST. The SSI-TM TL approach showed a higher post-test mean score than the SSI, and then the SSI post-test mean score was significantly higher than the CONV in all constructs studied except the Observation. The findings prove that the SSI-TM TL approach positively impacts the cultivation of EST among fifth graders.
Keywords: entrepreneurial science thinking, fifth graders, socioscientific issues approach, thinking wheel map,
STUDENTS’ PERCEPTIONS OF MULTIMEDIA USAGE IN TEACHING AND LEARNING QUANTUM PHYSICS: POST-ASSESSMENT
Authors: Nyirahabimana Pascasie , Minani Evariste , Nduwingoma Mathias , Kemeza Imelda
Published: February 2023

The research on students’ perceptions after implementing a teaching style is recommended due to its potential to inform reformed education. The present study surveyed 319 students and revealed their perceptions of multimedia usage in teaching and learning quantum physics. Among these students, 156 were surveyed after learning quantum physics with a multimedia-aided method, while 163 were surveyed after learning with a lecture method. The piloting of the test used generated Cronbach alpha of .841 of internal consistency, and it contained quantitative Likert scale items and supporting qualitative items. The data were analyzed descriptively and inductively. Students taught by multimedia perceived quantum physics as easy, while those taught by lecture perceived it as difficult due to its abstractness and mathematics needs. Students preferred computer simulations, animations, and YouTube videos as interactive methods that fit quantum physics lessons. Students testified that a quantum physics course that uses visualization methods in some of its teachings is more interesting than a course taught without them. However, students in both classes concurred that their class was student-centered and full of demonstration. Recommendations related to teaching practices and future research foci were made. Keywords: lecture method, multimedia-aided method, student perceptions, quantum physics, Rwanda
DIAGNOSTIC OF INFORMATION AND COMMUNICATION TECHNOLOGIES’ USE IN VOCATIONAL GUIDANCE: ANALYSIS OF AN EXPERIENCE
Authors: Sobrado Luis Martin , Ceinos Cristina , García Rebeca
Published: February 2023

In recent years, parallel to the transformations occurring at all levels, a technological revolution has taken place from which the development and integration of multiple resources in all areas and sectors has been derived.
All these changes have implications in Vocational Guidance, noting by its relevance in the present study, the integration and use of technological tools in the development of guidance tasks and the adoption by its technicians, the skills needed to make an effective use of them.
Taking as reference the above, the research problem of this work is focused on describing the use that professional counselors make of the Information and Communication Technologies (ICT) in the development of their daily work. With this purpose, we describe this study, in which, through quantitative and qualitative methods, we conclude, in general, the lack of true integration of ICT tools in guidance and a large deficit training in the group of counselors regarding to technological resources, which implies the need to design training activities with a view to remedying this deficiency.
Key words: information and communication technologies (ICT), technological competences, use of technological resources, vocational guidance.
IN AND AGAINST RADICAL MONOPOLY: CRITICAL EDUCATION AND INFORMATION AND COMMUNICATION TECHNOLOGIES
Authors: Jandric Petar
Published: February 2023

In the recent study “Ivan Illich Gone Digital: Convivial Information and Communication Technologies for Critical e-Learning” Jandric and Boras (2011) conducted counterfoil research of e-learning technologies. Results of this study strongly indicate that information and communication technologies might possess potentials to develop various radical monopolies, while education might be one of the main vehicles for such developments. Using the aforementioned study as the point of departure, this study confirms that information and communication technologies have the potentials to develop Illich’s radical monopolies and asserts that critical educators have a moral duty to act against such developments. Based on similarity between the position in and against radical monopoly of information and communication technologies and the position in and against the state, it adapts the conclusions developed in 1979 by the London Edinburgh Weekend Return Group to the context of contemporary information and communication technologies. Finally, it identifies oppositional possibilities for critical action against radical monopoly of information and communication technologies in the context of educational praxis. . Key words: critical education, information and communication technologies, Ivan Illich, radical monopoly.
Indeterminacy of Translation in Theological Spaces: The Èṣù-Satan/Devil Example
Authors: S. L. OLADIPUPO S. L.
Published: February 2023

The problem of linguistic interpretation continues to militate against intercultural philosophical discourse, with tendencies to create translatory confusions that take only critical analysis to detect. One of such confusions is the translation of Èṣù in Yoruba theology as Satan/Devil in the Abrahamic monotheistic religions such as Christianity and Islam.
ANTİK YUNAN’DAN YAŞAYAN SÖZLER’DE KADIN
Authors: ÜRETEN Hüseyin
Published: February 2023

Bu çalışma, tamamı modern dillere çevrilmiş olan Hesiodos, Aristophanes, Aiskhylos, Sophokles, Euripides, Demokritos ve Phaedrus’un eserlerinin satır aralarında gözümüze çarpan ilginç ve anlamlı sözleri bağlamında antik Hellen kadınını konu almaktadır. Çalışmanın belkemiğini antik Hellen dünyasının ünlü şair, yazar, filozof ve ozanlarının eserlerindeki satır aralarında antik Hellen kadınını anlatan sözlerin derlendiği “Antik Yunan’dan Yaşayan Sözler” adlı kitap oluşturmaktadır.

Amacım, hem tematik hem de kronolojik sıraya uyarak, yukarıda adları anılan antikçağın ünlü Hellen şair, yazar, filozof ve ozanların kadın konusundaki düşüncelerini kendi sözleriyle okuyucuya bir kere daha sunmak ve böylece antik Hellen dünyasında kadın konusunda küçük bir gezinti yaptırmaktır.
KÜRESELLEŞEN DÜNYA’DA DAĞ VE İNSAN ETKİLEŞİMİ: RİZE DAĞLARI ÖRNEĞİ
Authors: DOĞAN Kadir , DOĞAN Mesut
Published: February 2023

İnsan ve çevre arasındaki etkileşim tarih boyunca farklı şekillerde kendini göstermiş ve farklı sonuçlar ortaya koymuştur. Doğal çevre koşulları insan yaşamını şekillendirirken insan yaşanan gelişmelerle doğal çevre üzerinde değişiklikler meydana getirmeye başlamıştır. Bu çalışmada küreselleşme sürecindeki dünyada insan mekân ilişkisi incelenirken insanların dağlık bölgelerdeki faaliyetleri üzerinde durulmaya çalışılmıştır. Son yıllarda artan insan faaliyetlerinin tehditleri nedeniyle düzeyde dağların korunmasına ve zengin dağ ekosistemlerinin sürdürülebilirliğine yönelik uluslararası çalışmalar yapılmıştır. Çalışmada özellikle zengin su kaynaklarına, doğal güzelliklere, hassas ekosisteme ve kendisine has kültürel bir dokuya sahip olan Rize Dağları’ndaki insan çevre etkileşimi incelenmiştir. Doğu Karadeniz Kalkınma Projesi (DOKAP) kapsamında bu bölgede gerçekleştirilen ulaşım ve turizm yatırımlarının, artan enerji ihtiyacı nedeniyle yapılan hidroelektrik santrallerin ve çalışmaları devam eden madencilik faaliyetlerinin Rize Dağları’ndaki etkileri üzerinde durulmuştur.
İLK HALKA ARZLARIN KISA VE UZUN DÖNEM FİYAT PERFORMANSLARI İLE İŞLEM HACİMLERİ ARASINDAKİ İLİŞKİ: PANEL ASİMETRİK NEDENSELLİK ANALİZİ
Authors: DEMİRTAŞ Furkan , BARUT Abdulkadir , BARDAKÇİ Hasan , ALPSÜLÜN Mehmet Şükrü
Published: February 2023

Bu çalışmada, Borsa İstanbul’a ait 2002 ila 2015 döneminde halka ilk arz edilen 117 adet firmanın hisse senetlerinin 21 günlük ve 36 aylık fiyat performansı ile işlem hacmi arasındaki ilişkinin incelenmesi amaçlanmaktadır. Çalışmada, değişkenler arasındaki ilişki iki farklı şekilde incelenmiştir. Öncelikle, değişkenler bileşenlerine ayrılmadan temel halleri ile incelenmiştir. İkinci durumda ise değişkenlerin negatif ve pozitif bileşenleri arasındaki nedensellik ilişkisi incelenmiştir. Analiz yöntemi olarak Dumitrescu ve Hurlin Panel Granger Nedensellik analizi kullanılmıştır. Analizde ilk olarak değişkenlerin temel halleri 2002-2015 dönemi için incelenmiş ve halka arz edilen hisse senetlerinin kısa dönem fiyat performansları ile işlem hacimleri arasındaki nedensellik ilişkisi çift yönlü tespit edilmiştir. İkinci olarak, halka arz edilen hisse senetlerinin uzun dönem fiyat performansları ile işlem hacimleri arasındaki nedensellik ilişkisi incelenmiş ve benzer olarak iki değişken arasında çift yönlü nedensellik tespit edilmiştir. Asimetrik nedensellik sonuçlarına göre ise, ilk olarak 2002- 2015 dönemi için pozitif bileşenler arasındaki nedensellik ilişkisi incelenmiş ve hem kısa dönemde hem de uzun dönemde pozitif değişkenler arasında çift yönlü nedensellik tespit edilmiştir. 2002-2015 dönemi negatif bileşenler arasında ise; kısa dönemde çift yönlü nedensellik tespit edilirken uzun dönemde herhangi bir nedensellik tespit edilememiştir. 2010 -2015 döneminde hem kısa hem de uzun dönemde pozitif değişkenler arasında çift yönlü nedensellik tespit edilmiştir. Bu dönemde negatif bileşenler arasında ise kısa dönemde çift yönlü nedensellik tespit edilirken, uzun dönemde herhangi bir nedensellik tespit edilememiştir.
Pengaruh Berbagai Media Tanam Berbasis Limbah Kelapa Sawit terhadap Pertumbuhan Bibit Kelapa Sawit (Elaeis guineensis jacg) Pre Nursery
Authors: Ardiansyah Lucky handy , Mardiyani Siti Asmaniyah , Sholihah Anis
Published: February 2023

Oil palm (Elaeis guineensis Jacg.) is the top row of the largest plantation commodities and benefits from various things such as supporting the country's foreign exchange and also absorbing labor. This study aims to determine the effect of various planting media based on palm waste on the growth of pre nursery oil palm seedlings. This study used a simple randomized block design, consisting of 5 treatments which were repeated 3 times and each replicate contained 3 plant samples to obtain 45 polybags of plant samples. Observational data for each parameter were analyzed using the ANOVA test with a significant level of 5%. If there is a significant effect between the treatments, a further test will be carried out with a level of 5%. Parameters observed were plant height, stem diameter, number of leaves, leaf area, total fresh weight of roots, total dry weight of roots, and dry weight of roots. The results showed that the T3 treatment gave better results on the variable growth parameters: plant height 20.57 cm, stem diameter 7.53 mm, number of leaves 4.56 and leaf area 122.15 cm2 at 12 WAP observations. The results showed that the T3 treatment gave better results on the variable parameter observations total fresh weight of 11.09 grams, fresh root weight of 3.89 grams, total dry weight of 3.62 grams and root dry weight of 1.18 grams.
Yield and product quality of processed sandfish (Holothuria scabra) using different processing techniques
Authors:   Guiuan Development Foundation, Inc., Guimbaolibot Avenue, Poblacion Brgy. 10, Guiuan, Eastern Samar, 6809, Philippines., de la Cruz Margarita de la Torre , Villamor Janine L. ,   Guiuan Development Foundation, Inc., Guimbaolibot Avenue, Poblacion Brgy. 10, Guiuan, Eastern Samar, 6809, Philippines., Rey L. Gacura Jonh ,   Guiuan Development Foundation, Inc., Guimbaolibot Avenue, Poblacion Brgy. 10, Guiuan, Eastern Samar, 6809, Philippines., Rescordado Racelle R. ,   Guiuan Development Foundation, Inc., Guimbaolibot Avenue, Poblacion Brgy. 10, Guiuan, Eastern Samar, 6809, Philippines.
Published: February 2023

Four different techniques in processing sandfish: a) MB-method described by Brown et al. (2010), b) MN- from NFRDI, per Pardua et al. (2018), and two variations of method from Purcell (2014), c) MP1, and d) MP2 which were slightly modified and tried to compare resulting product quality and yield from freshly gutted sandfish. This demonstration was to encourage sandfish ranch managers to add value to their sandfish and ensure better earnings. Twenty-four sandfish individuals (350 to 870 g) harvested from the sea ranch site at Maliwaliw Island were used for processing at six individuals per technique. Results show that live sandfish weight was reduced to 45% after gutting. MB had the highest weight percent recovery from gutted weight at 10.75%, not significantly different (p > 0.05) from MN at 9.65% but significantly higher (p < 0.05) from MP1 (9.38%) and MP2 (9.50%). In terms of product quality, bigger sandfish >600 g produced good quality products when processed correctly. Bêche-de-mer is priced based on three criteria: quality of the product, size length, and weight. Although there is no single best-practice method for processing sandfish, sea ranch managers may opt to adopt the MB and MN for a simpler procedure to save time and resources, and higher product yield for better income. Keywords: Sandfish, processing techniques, yield, balat, product quality.
A new species of Myxobolus (Cnidaria: Myxosporea: Myxobolidae) from the gibel carp Carassius gibelio (Cypriniformes: Cyprinidae)
Authors: Batueva MDD , Liu XH , Zhang JY , Voronin VN , Naydanov TI , Abasheev RY
Published: February 2023

Myxobolus zhaltsanovae n. sp., is described from the gills of gibel carp Carassius gibelio found during a survey of myxozoans from the watershed of Lake Baikal, Russia, based on morphological and molecular characterizations. Plasmodia of M. zhaltsanovae n. sp. develop extravascularly and measure 500-1000 μm long, 25-100 μm wide. The myxospore is circular to oval, measuring 13.23 ± 0.09 (11.3-14.8) µm (mean ± SD, range) in length, 10.19 ± 0.07 (9.1-11.4) µm in width, and 6.49 ± 0.12 (5.4-7.2) µm in thickness. Polar capsules are unequal and subspherical; measurements of polar capsules are: length 5.62 ± 0.06 (4.7-6.7), width 3.44 ± 0.04 (2.4-4.4) µm and length 3.42 ± 0.05 (2.5-4.1), width 1.94 ± 0.04 (1.3-3.3) µm. Phylogenetic analysis with the 18S rDNA gene shows M. zhaltsanovae n. sp. as a sister species of the subclade formed by M. musseliusae, M. tsangwuensis, and M. basilamellaris, which infect common carp Cyprinus carpio.
Benzodiazepines in the Treatment of Behavioural and Psychological Symptoms Associated with Dementia and Their Impact on Cognitive Impairment: Review of Clinical Evidence
Authors: Stranieri Pasqualina , Cordaro Rosa Maria
Published: February 2023

Alzheimer’s disease (AD) is the most common form of progressively disabling degenerative dementia. In dementia in general, there are, unfortunately, even from the earliest stages of the disease, associated behavioural and psychological symptoms of dementia (BPSD), and even more pronouncedly in AD, in addition to cognitive impairment. There are no specific drugs for the treatment of BPSDs. Therefore, there remains an unmet medical need. To date, despite side effects, benzodiazepines, anti-psychotics, mood stabilisers, and anti-depressants continue to be used in the clinic. The aim of this research work is to provide an understanding of the role of benzodiazepines when used for the treatment of BPSD and cognitive impairment in AD.
Atrial Fibrillation in Childhood with Familial Hyperthyroidism in Afro-Caribbeans
Authors: Williams-Phillips Sandra
Published: February 2023

Atrial fibrillation (AF) associated with familial hyperthyroidism (FH) spanning three generations concomitantly, is rare. The index case was 10 years old when he started having AF secondary to hyperthyroidism, and is the youngest case documented. His mother was diagnosed at 31 years of age, 8 years after giving birth to him; and his maternal grandmother was diagnosed with the same goitre problem, hyperthyriodism, and palpitations at 49 years of age. The index case also has a restrictive perimembranous ventricular septal defect, which makes it a clinically challenging and more interesting case.
Managing Thromboembolic Risks of Atrial Fibrillation: Can We Afford Increased Efficacy of the Novel Anticoagulants and Devices?
Authors: Merkely Bela , Vegh Eszter M. , Roka Attila
Published: February 2023

Ischaemic/embolic complications are the most common severe consequences of atrial fibrillation. Although chronic anticoagulation with warfarin has been available for decades, it was consistently shown to be underutilised; multiple drug interactions and dietary issues further complicate its use. Recently, several pharmacological and non-pharmacological alternatives have been shown to have an efficacy that is similar or slightly superior to warfarin. Novel anticoagulant agents (dabigatran, rivaroxaban, apixaban) have the advantage of a fixed dose, without the need of regular monitoring. Non-pharmacological options include left atrial appendage ligation or percutaneous closure. Although all these options are more expensive than warfarin, they have the potential of being more cost-effective – preventing very expensive complications or having less side-effects (such as haemorrhagic stroke), requiring less or no monitoring, and having fewer interactions with diet, thus, improving quality of life. Multiple studies of simulated cost-efficacy analyses have been published recently, addressing these questions, which will be reviewed in this paper. In the era of cost-conscious utilisation of healthcare resources, these new treatment options may increase the number of patients benefitting from effective therapies, reducing the number of ischaemic complications of atrial fibrillation.
Transforming Growth Factor Beta-Based Therapies, a Potential Modulator of the Immune Response in Type 1 Diabetes?
Authors: Green E. Allison
Published: February 2023

Immunobiological interventions are proving to be an exciting new area for mobilising the immune response towards certain tumours. In contrast, classical immunotherapeutic interventions aimed at dampening the autoimmune response to host tissue have been less successful; this is particularly evident for Type 1 diabetes (T1D). In part, the failure to control autoimmunity in T1D relates to the complexity of the immune response to β cells. To resolve this dilemma, immunologists are turning to immunobiological agents that were initially deemed too high risk for therapeutic use due to their potential to inadvertently promote autoimmunity or induce deleterious side effects. Two of these immunobiological mediators under consideration are transforming growth factor β (TGFβ) and tolerogenic dendritic cells (DCs), both of which have shown robust control of the anti-islet response in animal models of T1D, the latter also recently documented to be acceptable for trialling in patients with T1D. In this review, both the challenges of translating immunobiological therapies discovered in animal models of T1D to man and the potential of TGFβ and tolerogenic DCs in the T1D setting will be discussed.
Utility of Bedside Lung Ultrasound in the Assessment of Volume Status in Patients on Chronic Haemodialysis
Authors: Jeswani Jitesh , Bhardwaj Ankit , Bhatt Shuchi
Published: February 2023

Aim: The estimation of the ‘dry weight’ in a patient on haemodialysis with end-stage renal disease is an important clinical challenge to date. Physical examination has its limitations in the precise assessment of volume status. The monitoring of blood volume, natriuretic peptides, and bioimpedance spectroscopy are explored as a guide for the ultrafiltration process during haemodialysis (HD) therapy. Unfortunately, none of these methods has shown promising results when used in isolation and has serious limitations. The point-of-care lung ultrasonography has emerged recently as an adjunct to physical examination as a non-invasive, radiation-free technique to estimate extravascular lung water. In this study, the authors aimed to compare the volume status assessment in end-stage renal disease patients on HD using conventional clinical methods, bio-electrical impedance, and chest ultrasound (US).

Materials and Methods: A prospective cohort study was conducted on 34 patients undergoing regular HD in the Department of Nephrology dialysis centre at the University College of Medical Sciences Guru Teg Bahadur Hospital, Delhi, India, a multi-speciality tertiary care centre. Parameters included to assess the dry weight of patients were bio-impedance spectroscopy and chest US, measured in two phases: 30 minutes before and 10–60 minutes following the HD session.

Results: A total of 100 assessments were done on 34 patients over 6 months. The mean pre-HD extracellular water was 17.52±2.69 L and post-HD was 16.38±2.46 L, showing a significant reduction (<0.001). The bioimpedance analysis showed that 44% of the volume status assessments had fluid overload (≥1.1 L), even when the patients were considered to be in a state of clinical euvolemia, while 79% of the assessments had a Comet Score of ≥3 suggesting a fluid overload state. Most assessments showed a significant reduction in the number of B-lines (i.e., 62% [Comet Score of between 0–2]). The mean post-HD Comet Score was 1.73±1.36 (37%).

Conclusion: Chest US to assess Comet Score is highly correlated with the clinical signs and symptoms. Lung Comet Scores can also be highly correlated with ultrafiltration volume, and thus can be used as a good marker for achieving dry weight in dialysis patients.
Practice-Led Research in the COVID-19 Era: My Conversion of a Drama in Education Project into an Asynchronous Online Workshop
Authors: Peng Lance
Published: February 2023

All domains are currently coping with their works remotely. Especially for educators, teaching, learning, and researching are in every way dissimilar to what is usually done but have progressively evolved into an unanticipated but innovative aspect. This presentation zeros in on my personal experience of adapting research practice and creating an online drama workshop. Two subjects and a conclusion are included. The first subject is the examination of the definition of DiE (Drama in Education) under typical face-to-face circumstances. Next I will share my masters dissertation, where I organised a face-to-face DiE project and subsequently, in light of the outbreak, transformed it into an asynchronous online workshop. The second subject is the exploration of the conversion and how it means to conduct a practice-led research connected with educational technology in the time of a pandemic.
Research in the Time of a Pandemic: What Is It Like to Shift From Forming a Face-to-Face Drama in Education to Organising an Asynchronous Semi-Autobiographical Workshop?
Authors: Peng Lance
Published: February 2023

People from all fields are remotely dealing with their works, in addition to adaptations in every dimension of daily life respecting coronavirus health information. This presentation, reflecting the current circumstances and echoing the above concepts, will firstly examine the challenges in academia pertaining to pandemic-related developments and provide a literature review on the use of technologies in education under COVID-19. Next and also the highlight of this presentation, I will share the journey of my masters dissertation and touch on my conversion of a DiE (Drama in Education) project into an asynchronous online workshop in view of the outbreak. I will zero in on the transformation and how it means to conduct research connected with educational technology in the time of a pandemic. Reshaping ourselves, both as researchers and as human beings, during crisis will also be one of the focal points of this presentation.
Elimination of enzymes catalysis compartmentalization enhancing taxadiene production in Saccharomyces cerevisiae
Authors: Zhang Chenglong , Chen Wang , Dong Tianyu , Wang Ying , Yao Mingdong , Xiao Wenhai , Li Bingzhi
Published: February 2023

Taxadiene is an important precursor in taxol biosynthesis pathway, but its biosynthesis in eukaryotic cell factories is limited, which seriously hinders the biosynthesis of taxol. In this study, it is found that there was the catalysis compartmentalization between two key exogenous enzymes of geranylgeranyl pyrophosphate synthase and taxadiene synthase (TS) for taxadiene synthesis progress, due to their different subcellular localization. Firstly, the enzyme-catalysis compartmentalization was overcome by means of the intracellular relocation strategies of taxadiene synthase, including N-terminal truncation of taxadiene synthase and enzyme fusion of GGPPS-TS. With the help of two strategies for enzyme relocation, the taxadiene yield was increased by 21% and 54% respectively, among them the GGPPS-TS fusion enzyme is more effective. Further, the expression of GGPPS-TS fusion enzyme was improved via the multi-copy plasmid, resulting that the taxadiene titer was increased by 38% to 21.8 mg/L at shake-flask level. Finally, the maximum taxadiene titer of 184.2 mg/L was achieved by optimization of the fed-batch fermentation conditions in 3 L bioreactor, which is the highest reported titer of taxadiene biosynthesis accomplished in eukaryotic microbes. This study provides a successful example for improving biosynthesis of complex natural products by solving the critical problem of multistep enzymes catalysis compartmentalization.
A critical review of the relationship between type 1 diabetes mellitus, inhibition, and behavioral management
Authors: Robertson Neville Dean , Deacon Elmari , Botha Karel
Published: February 2023

Type 1 diabetes mellitus (T1DM) is a chronic and lifelong condition that requires adequate behavior management in order to meet desired health outcomes. The effects of T1DM on the neurocognitive functioning of affected individuals raise concerns about how the disease may influence executive functioning. Inhibition is a core component of executive functioning, and plays a vital role in self-regulation and the restriction of impulsive behaviors. Inhibition may thus play a vital role in the behavior management of people with T1DM. The aim of this study was to identify current gaps in existing knowledge regarding the relationship between T1DM, inhibition, and behavior management. This study employed a critical review design to analyze and synthesize the current scientific literature. Twelve studies were identified through an appraisal process, and the data extracted were thematically analyzed and integrated. The findings of this study indicate that a possible cycle arises between these three constructs, in which T1DM affects inhibition, inhibition affects behavior management, and poor behavior management affects inhibition. It is recommended that future research should focus more specifically on this relationship.
The early modern age in secondary education textbooks in Spain: An analysis of activities
Authors: Simón-García María Del Mar
Published: February 2023

The objective of this study is to analyse how the Early Modern Age is taught in secondary school textbooks in Spain. To do so, the study is focused on the analysis of the historical contents of this period, in relation to the topics proposed by historiographical trends. In addition, the textbook activities has been analised according to their type, cognitive level and the historical skills required of secondary students. The sample consists of a total of 770 activities. A mixed methodology has been used, combining quantitative and qualitative techniques. The results obtained indicate that the textbooks have improved in the type of activities and in the cognitive level required, but continue to dominate the contents of concepts, facts and concrete data (related to political and cultural history). On the other hand, the textbooks present a discourse which does not debate or reflect in the development of many of the historiographical stereotypes of the nation, neither does it examine in depth the social problems of the Early Modern Age.
The transcriptomic and epigenetic alterations in type 2 diabetes mellitus patients of Chinese Tibetan and Han populations
Authors: Wang Xian , Liu Jie , Wang Qiuhong , Chen Qiu
Published: February 2023

Background

Due to the distinctive living environment, lifestyle, and diet, the Tibetan community in China has the lowest prevalence of T2DM and prediabetes among numerous ethnic groups, while Han community shows the highest statistic. In this study, we aim to conclude the clinical manifestations of both Tibetan and Han T2DM patients and their association with transcriptomic and epigenetic alterations.

Methods

A cross-sectional study including 120 T2DM patients from Han and Tibetan ethnic groups were conducted between 2019 to 2021 at the Hospital of Chengdu University of Traditional Chinese Medicine. The various clinical features and laboratory tests were recorded and analyzed between the two groups. The genome-wide methylation pattern and RNA expression were determined by Reduced Representation Bisulfite Sequencing (RBBS) and Poly (A) RNA sequencing (RNA-seq) from leucocytes of peripheral blood samples in 6 Han and 6 Tibetan patients. GO analysis and KEGG analysis were conducted in differentially expressed genes and those with differentially methylated regions.

Results

Compared to Han, Tibetan T2DM individuals intake more coarse grains, meat and yak butter, but less refined grains, vegetables and fruit. They also showed increased BMI, Hb, HbA1c, LDL, ALT, GGT and eGFR, and decreased level of BUN. Among the 12 patients in the exploratory cohort, we identified 5178 hypomethylated and 4787 hypermethylated regions involving 1613 genes in the Tibetan group. RNA-seq showed a total of 947 differentially expressed genes (DEGs) between the two groups, with 523 up-regulated and 424 down-regulated in Tibetan patients. By integrating DNA methylation and RNA expression data, we identified 112 DEGs with differentially methylated regions (overlapping genes) and 14 DEGs with promoter-related DMRs. The functional enrichment analysis demonstrated that the overlapping genes were primarily involved in metabolic pathways, PI3K-Akt signaling pathway, MAPK signaling pathway, pathways in cancer and Rap1 signaling pathway.

Conclusion

Our study demonstrates the clinical characteristics of T2DM differ subtly between various ethnic groups that may be related to epigenetic modifications, thus providing evidence and ideas for additional research on the genetic pattern of T2DM.
To block or not to block—hormonal signaling in the treatment of cancers
Authors: Abikar Apoorva , Saimon Chriswin , Ranganathan Prathibha
Published: February 2023

The breast and prostate glands are the two major organs that are highly dependent on the gonadal steroid hormones for their development and homeostasis. The cancers of these organs also show a large dependence on steroid hormones and have formed the basis of endocrine therapy. Estrogen deprivation by oophorectomy has been in active practice since the 1970s, and androgen deprivation therapy for prostate cancer was a major breakthrough in medicine in 1941. Since then, several improvisations have happened in these modes of therapy. However, the development of resistance to this deprivation and the emergence of hormone independence are major problems in both cancers. The lessons learned from rodent models have made it clear that the male hormone has a role in females and vice versa. Also, the metabolic products of these hormones may have unintentional effects including proliferative conditions in both sexes. Hence, administering estrogen as a method of chemical castration in males and administering DHT in females may not be the ideal scenario. It would be important to consider the status of the opposite sex hormone signaling and its effects and come up with a combinatorial regime to strike a balance between androgen and estrogen signaling. This review summarizes the current understanding and developments in this field in the context of prostate cancer.
Cold plate performance enhancement based on parametric modeling of multiple structures
Authors: Zhao Kai , Sun Xiaoxia , Xia Yuanqing , Li Qiangqiang , Shen Lili , Lin Min
Published: February 2023

Power electronic equipment to miniaturization, high integration direction while facing the problem of high heat flow density and uneven temperature distribution. The large temperature fluctuations and uneven temperature distribution in the operation of power electronic equipment will lead to thermal stress, and excessive thermal stress or uneven distribution will cause fatigue failure of the packaging material, resulting in reduced reliability, module failure, and reduced life of power electronic equipment. In this paper, we propose two kinds of liquid-cooled flow channel non-linear reinforced heat transfer homogeneous liquid-cooled plate, which is theoretically derived to achieve the design requirement of uniform temperature on the heating side wall surface. The thermal design of the cold plate is carried out using ANSYS Workbench, and the indicators of various structures of the cold plate are analyzed and compared in terms of their ability to dissipate heat and maintain temperature uniformity. Based on the original runner structure, the heat dissipation performance of the rod structure and fin structure was evaluated, and the form of the internal heat dissipation structure of the runner was determined. The results show that the integrated liquid cooling plate temperature uniformity and flow resistance of both factors, the fin column heat sink is significantly better than the cylindrical fin column heat sink in the case of the same thermal resistance, the fin column heat sink flow resistance is significantly lower than the cylindrical fin column heat sink.
The driving mechanisms for human settlement and ecological environment in the upper minjiang watershed, China
Authors: Liao Bo , Wang Zelin , He Jing , Wu Jiaxing , Su Jiafu
Published: February 2023

The Chinese urbanization process is undergoing rapid development and intensification. There is, however, little awareness of spatial development in rural areas, particularly in watersheds that are relatively backward. Consequently, human settlements have been disrupted and environmental damage has been caused. The upper reaches of the Minjiang River are not yet aware of the limited space resources and environmental elements due to topography, climate, and other factors, resulting in an unbalanced development. Human settlements and ecological environments are examined in this paper in light of the adaptive development strategy of the upper reaches of the Minjiang River watershed. This paper establishes a “habitat-ecology” variable system for the purpose of adaptability research. The study identified 35 explanatory variables, including 17 in the category of human settlements and 18 in the category of ecological environment. A total of 12 relevant research sample areas have been selected, including five target sample areas and seven comparison sample areas. As a result of differential analysis and correlation research, explanatory variables with high significance were identified as characteristic variables. In addition, a driving mechanism between human settlement and ecological environment is determined using correlation analysis results, optimal subset equations, and independent effects of variables. The results show that in the “habitat-ecology” driving mechanism model: (1) In terms of human settlement, factors such as population density, proportion of construction land, and service scope of medical facilities are the most prominent; (2) In terms of ecological environment, factors such as regional proportion, per capita water area, net flow, and grassland coverage are the most prominent; (3) Based on the element configuration of the above two research subjects, the driving mechanism with human settlement as the driving force and ecological environment as the carrying capacity is obtained.
Short-term responses of soil nutrients and enzyme activities to nitrogen addition in a Larix principis-rupprechtii plantation in North China
Authors: Yang Xiaocong , Yang Liu , Li Qianru , Li Xiao , Xu Guoqiao , Xu Zhongqi , Jia Yanlong
Published: February 2023

Atmospheric nitrogen (N) deposition is among the main manifestations of global change and has profoundly affected forest biogeochemical cycles. However, the threshold of N deposition to soil nutrient contents and enzyme activities has rarely been studied in a forest. In this study, we explored the effects of N deposition on soil nutrients and enzyme activities in a Larix principis-rupprechtii plantation on the northern Yanshan Mountain through multigradient N addition experiments (0, 5, 10, 20, 40, 80, and 160 kg N ha−1 year−1) after fertilization for 2 years. Compared with the controls, N addition first led to a decrease in soil NH4+-N and NO3--N, which then increased significantly. N addition had no significant effects on other soil nutrients. N addition overall elevated soil β-glucosidase activity. N application of >40 kg N ha−1 year−1 significantly reduced soil leucine aminopeptidase activity but had no significant effects on soil acid phosphatase, N-acetyl-β-D-glucosidase, and urease activities. N addition increased the overall stoichiometry ratio of EEA C:N and EEA C:P, but EEA N:P started decreasing after N application of 40 kg N ha−1 year−1. The ratios of C, N, and P acquisition activities changed from 1:1.2:1 under the control conditions to 1:1.1:1 under the N application of 160 kg N ha−1 year−1. N addition increased the overall vector length and had no significant effects on the vector angle. Correlation and redundancy analyses revealed that N addition-induced change in available soil N was the main factor affecting soil enzyme activity and stoichiometry. In general, different enzyme activities had different sensitivities to N addition. Moderate N addition or atmospheric N deposition (e.g., <40 kg N ha−1 year−1) had beneficial effects on soil nutrient cycling and microorganisms in a Larix principis-rupprechtii plantation.
Effects of Dlx2 overexpression on the genes associated with the maxillary process in the early mouse embryo
Authors: Sun Jian , Zhang Jianfei , Bian Qian , Wang Xudong
Published: February 2023

The transcription factor Dlx2 plays an important role in craniomaxillofacial development. Overexpression or null mutations of Dlx2 can lead to craniomaxillofacial malformation in mice. However, the transcriptional regulatory effects of Dlx2 during craniomaxillofacial development remain to be elucidated. Using a mouse model that stably overexpresses Dlx2 in neural crest cells, we comprehensively characterized the effects of Dlx2 overexpression on the early development of maxillary processes in mice by conducting bulk RNA-Seq, scRNA-Seq and CUT&Tag analyses. Bulk RNA-Seq results showed that the overexpression of Dlx2 resulted in substantial transcriptome changes in E10.5 maxillary prominences, with genes involved in RNA metabolism and neuronal development most significantly affected. The scRNA-Seq analysis suggests that overexpression of Dlx2 did not change the differentiation trajectory of mesenchymal cells during this development process. Rather, it restricted cell proliferation and caused precocious differentiation, which may contribute to the defects in craniomaxillofacial development. Moreover, the CUT&Tag analysis using DLX2 antibody revealed enrichment of MNT and Runx2 motifs at the putative DLX2 binding sites, suggesting they may play critical roles in mediating the transcriptional regulatory effects of Dlx2. Together, these results provide important insights for understanding the transcriptional regulatory network of Dlx2 during craniofacial development.
Evaluating SARS-CoV-2 antibody reactivity to natural exposure and inactivated vaccination with peptide microarrays
Authors: Zheng Peiyan , Ma Jing , Yang Jiao , Liao Baolin , Cheng Zhangkai J. , Xue Mingshan , Li Shiyun , Fang Yanting , Lin Runpei , Zhang Guizhen , Huang Huimin , Hu Fengyu , Ma Hongwei , Sun Baoqing
Published: February 2023

Objective

Vaccination is effective tool for preventing and controlling SARS-CoV-2 infections, and inactivated vaccines are the most widely used type of vaccine. In order to identify antibody-binding peptide epitopes that can distinguish between individuals who have been vaccinated and those who have been infected, this study aimed to compare the immune responses of vaccinated and infected individuals.

Methods

SARS-CoV-2 peptide microarrays were used to assess the differences between 44 volunteers inoculated with the inactivated virus vaccine BBIBP-CorV and 61 patients who were infected with SARS-CoV-2. Clustered heatmaps were used to identify differences between the two groups in antibody responses to peptides such as M1, N24, S15, S64, S82, S104, and S115. Receiver operating characteristic curve analysis was used to determine whether a combined diagnosis with S15, S64, and S104 could effectively distinguish infected patients from vaccinated individuals.

Results

Our findings showed that the specific antibody responses against S15, S64, and S104 peptides were stronger in vaccinators than in infected persons, while responses to M1, N24, S82, and S115 were weaker in asymptomatic patients than in symptomatic patients. Additionally, two peptides (N24 and S115) were found to correlate with the levels of neutralizing antibodies.

Conclusion

Our results suggest that antibody profiles specific to SARS-CoV-2 can be used to distinguish between vaccinated individuals and those who are infected. The combined diagnosis with S15, S64, and S104 was found to be more effective in distinguishing infected patients from those who have been vaccinated than the diagnosis using individual peptides. Moreover, the specific antibody responses against the N24 and S115 peptides were found to be consistent with the changing trend of neutralizing antibodies.
The mast cell: A Janus in kidney transplants
Authors: van der Elst G. , Varol H. , Hermans M. , Baan C. C. , Duong-van Huyen J. P. , Hesselink D. A. , Kramann R. , Rabant M. , Reinders M. E. J. , von der Thüsen J. H. , van den Bosch T. P. P. , Clahsen-van Groningen M. C.
Published: February 2023

Mast cells (MCs) are innate immune cells with a versatile set of functionalities, enabling them to orchestrate immune responses in various ways. Aside from their known role in allergy, they also partake in both allograft tolerance and rejection through interaction with regulatory T cells, effector T cells, B cells and degranulation of cytokines and other mediators. MC mediators have both pro- and anti-inflammatory actions, but overall lean towards pro-fibrotic pathways. Paradoxically, they are also seen as having potential protective effects in tissue remodeling post-injury. This manuscript elaborates on current knowledge of the functional diversity of mast cells in kidney transplants, combining theory and practice into a MC model stipulating both protective and harmful capabilities in the kidney transplant setting.