bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table from Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors
Authors: Bankson James A. , Walker Christopher M. , Ramirez Marc S. , Stefan Wolfgang , Fuentes David , Merritt Matthew E. , Lee Jaehyuk , Sandulache Vlad C. , Chen Yunyun , Phan Liem , Chou Ping-Chieh , Rao Arvind , Yeung Sai-Ching J. , Lee Mong-Hong , Schellingerhout Dawid , Conrad Charles A. , Malloy Craig , Sherry A. Dean , Lai Stephen Y. , Hazle John D.
Published: April 2023

Summary statistics for kpl, the apparent rate of conversion for HP Pyruvate to lactate, under various measurement conditions and parameter constraints due to differing prior information.
Supplemental Figure 8 from Nucleolin Promotes Heat Shock–Associated Translation of VEGF-D to Promote Tumor Lymphangiogenesis
Authors: Morfoisse Florent , Tatin Florence , Hantelys Fransky , Adoue Aurelien , Helfer Anne-Catherine , Cassant-Sourdy Stephanie , Pujol Françoise , Gomez-Brouchet Anne , Ligat Laetitia , Lopez Frederic , Pyronnet Stephane , Courty Jose , Guillermet-Guibert Julie , Marzi Stefano , Schneider Robert J. , Prats Anne-Catherine , Garmy-Susini Barbara H.
Published: April 2023

Figure S8. Schematic representation of VEGF-D synthesis in tumor cells
Table S1 from Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells
Authors: Timosenko Elina , Ghadbane Hemza , Silk Jonathan D. , Shepherd Dawn , Gileadi Uzi , Howson Lauren J. , Laynes Robert , Zhao Qi , Strausberg Robert L. , Olsen Lars R. , Taylor Stephen , Buffa Francesca M. , Boyd Richard , Cerundolo Vincenzo
Published: April 2023

Table S1. Oligonucleotides used for generation of CRISPR guide sequences targeting SLC1A5, ATF4 or LAT1.
Supplementary Materials and Methods from Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells
Authors: Timosenko Elina , Ghadbane Hemza , Silk Jonathan D. , Shepherd Dawn , Gileadi Uzi , Howson Lauren J. , Laynes Robert , Zhao Qi , Strausberg Robert L. , Olsen Lars R. , Taylor Stephen , Buffa Francesca M. , Boyd Richard , Cerundolo Vincenzo
Published: April 2023

Supplementary materials and methods.
Supplemental Figure 4 from Nucleolin Promotes Heat Shock–Associated Translation of VEGF-D to Promote Tumor Lymphangiogenesis
Authors: Morfoisse Florent , Tatin Florence , Hantelys Fransky , Adoue Aurelien , Helfer Anne-Catherine , Cassant-Sourdy Stephanie , Pujol Françoise , Gomez-Brouchet Anne , Ligat Laetitia , Lopez Frederic , Pyronnet Stephane , Courty Jose , Guillermet-Guibert Julie , Marzi Stefano , Schneider Robert J. , Prats Anne-Catherine , Garmy-Susini Barbara H.
Published: April 2023

Figure S4. Lymphangiogenesis and tumor gowth are not affected by 4T1 or 67NR lentiviral transduction
Supplemental Figure 2 from Nucleolin Promotes Heat Shock–Associated Translation of VEGF-D to Promote Tumor Lymphangiogenesis
Authors: Morfoisse Florent , Tatin Florence , Hantelys Fransky , Adoue Aurelien , Helfer Anne-Catherine , Cassant-Sourdy Stephanie , Pujol Françoise , Gomez-Brouchet Anne , Ligat Laetitia , Lopez Frederic , Pyronnet Stephane , Courty Jose , Guillermet-Guibert Julie , Marzi Stefano , Schneider Robert J. , Prats Anne-Catherine , Garmy-Susini Barbara H.
Published: April 2023

Figure S2. Expression of endogenous VEGF-D in mice tissues
Supplementary Table 1 from The CARMA3–Bcl10–MALT1 Signalosome Drives NFκB Activation and Promotes Aggressiveness in Angiotensin II Receptor–Positive Breast Cancer
Authors: Ekambaram Prasanna , Lee Jia-Ying (Lloyd) , Hubel Nathaniel E. , Hu Dong , Yerneni Saigopalakrishna , Campbell Phil G. , Pollock Netanya , Klei Linda R. , Concel Vincent J. , Delekta Phillip C. , Chinnaiyan Arul M. , Tomlins Scott A. , Rhodes Daniel R. , Priedigkeit Nolan , Lee Adrian V. , Oesterreich Steffi , McAllister-Lucas Linda M. , Lucas Peter C.
Published: April 2023

Custom NanoString codeset for evaluating 72 NFkB regulated genes.
Figure S1 from Noninvasive In Vivo Imaging and Biologic Characterization of Thyroid Tumors by ImmunoPET Targeting of Galectin-3
Authors: D'Alessandria Calogero , Braesch-Andersen Sten , Bejo Kristel , Reder Sybille , Blechert Birgit , Schwaiger Markus , Bartolazzi Armando
Published: April 2023

Immunohistochemical analysis of galectin-3 expression in xenografted tumors ex vivo.
Supplementary Materials and Methods from Natural Product Vibsanin A Induces Differentiation of Myeloid Leukemia Cells through PKC Activation
Authors: Yu Zu-Yin , Xiao He , Wang Li-Mei , Shen Xing , Jing Yu , Wang Lin , Sun Wen-Feng , Zhang Yan-Feng , Cui Yu , Shan Ya-Jun , Zhou Wen-Bing , Xing Shuang , Xiong Guo-Lin , Liu Xiao-Lan , Dong Bo , Feng Jian-Nan , Wang Li-Sheng , Luo Qing-Liang , Zhao Qin-Shi , Cong Yu-Wen
Published: April 2023

Description of additional methods and procedures used in the study.
Suppl Fig Legends from GALNT1-Mediated Glycosylation and Activation of Sonic Hedgehog Signaling Maintains the Self-Renewal and Tumor-Initiating Capacity of Bladder Cancer Stem Cells
Authors: Li Chong , Du Ying , Yang Zhao , He Luyun , Wang Yanying , Hao Lu , Ding Mingxia , Yan Ruping , Wang Jiansong , Fan Zusen
Published: April 2023

Supplementary Figure Legends
Supplementary Material and Methods from Syndecan-1 (CD138) Suppresses Apoptosis in Multiple Myeloma by Activating IGF1 Receptor: Prevention by SynstatinIGF1R Inhibits Tumor Growth
Authors: Beauvais DeannaLee M. , Jung Oisun , Yang Yang , Sanderson Ralph D. , Rapraeger Alan C.
Published: April 2023

Materials and Methods that apply to the supplemental figures
Table S1 from CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma
Authors: Walton Josephine , Blagih Julianna , Ennis Darren , Leung Elaine , Dowson Suzanne , Farquharson Malcolm , Tookman Laura A. , Orange Clare , Athineos Dimitris , Mason Susan , Stevenson David , Blyth Karen , Strathdee Douglas , Balkwill Frances R. , Vousden Karen , Lockley Michelle , McNeish Iain A.
Published: April 2023

Legend for sequencing variants
Supplementary Figures from HSPB1 Inhibits the Endothelial-to-Mesenchymal Transition to Suppress Pulmonary Fibrosis and Lung Tumorigenesis
Authors: Choi Seo-Hyun , Nam Jae-Kyung , Kim Bu-Yeo , Jang Junho , Jin Young-Bae , Lee Hae-June , Park Seungwoo , Ji Young Hoon , Cho Jaeho , Lee Yoon-Jin
Published: April 2023

Supplementary Figures 1-12. Supplementary Figure 1. Effects of HSPB1, VEGFR1, or VEGFR2 knockdown on the EndMT in HPMECs. Supplementary Figure 2. Effects of HSPB1 knockdown or overexpression on EC-specific characteristics and Smad3 inhibitor on HSPB1 knockdown-induced EndMT. Supplementary Figure 3. HSPB1 deficiency-induced EndMT in human pulmonary artery ECs (HPAECs) and human umbilical vein ECs (HUVECs). Supplementary Figure 4. Analysis of radiation-induced cytokines in irradiated mice serum and the effects of fibrosis-related cytokines on HSPB1-deficient HPMECs. Supplementary Figure 5. The role of STAT3 phosphorylation on HSPB1-regulated EndMT. Supplementary Figure 6. Effects of endothelial HSPB1 overexpression or JAK2 inhibitor on radiation-induced lung fibrosis. Supplementary Figure 7. The effects of HSPB1 knockdown on the radiation-induced lung fibrosis. Supplementary Figure 8. The effects of conditioned medium (CM) from irradiated ECs on other cells. Supplementary Figure 9. The effects of endothelial HSPB1 overexpression on bleomycin-induced lung fibrosis. Supplementary Figure 10. HSPB1 knockdown-induced vascular damage and hemorrhage. Supplementary Figure 11. Effects of HSPB1 knockdown on tumor ECs and tumor cells isolated from lung adenocarcinomas from LSL-KrasG12D;Trp53fl/fl mice. Supplementary Figure 12. Effects of HSPB1 knockdown on tumor cells in lung adenocarcinomas from LSL-KrasG12D;Trp53fl/fl mice.
Supplementary Table 2 from Integrative Genomic Analysis Identifies the Core Transcriptional Hallmarks of Human Hepatocellular Carcinoma
Authors: Allain Coralie , Angenard Gaëlle , Clément Bruno , Coulouarn Cédric
Published: April 2023

Description of the core human HCC signature.
Supplementary Figures 1 and 2 from Integrative Genomic Analysis Identifies the Core Transcriptional Hallmarks of Human Hepatocellular Carcinoma
Authors: Allain Coralie , Angenard Gaëlle , Clément Bruno , Coulouarn Cédric
Published: April 2023

Supplementary Figure 1. Reversion of the core transcriptional programming of HCC cells by selected drugs. Supplementary Figure 2. Four-way Venn diagram comparing gene sets included in S1, S2 and S3 HCC subtype signatures from Hoshida's study [1] and our core HCC signature.
SUPPLEMENTARY MATERIALS AND METHODS from HDAC1 Upregulation by NANOG Promotes Multidrug Resistance and a Stem-like Phenotype in Immune Edited Tumor Cells
Authors: Song Kwon-Ho , Choi Chel Hun , Lee Hyo-Jung , Oh Se Jin , Woo Seon Rang , Hong Soon-Oh , Noh Kyung Hee , Cho Hanbyoul , Chung Eun Joo , Kim Jae-Hoon , Chung Joon-Yong , Hewitt Stephen M. , Baek Seungki , Lee Kyung-Mi , Yee Cassian , Son Minjoo , Mao Chih-Ping , Wu T.C. , Kim Tae Woo
Published: April 2023

Cell lines, Western blot (WB) analysis, Luciferase assay, Trypan blue exclusion assay, Immunohistochemistry, ChIP and quantitative ChIP (qChIP) assays, SUPPLEMENTARY REFERENCES.
SUPPLEMENTARY Figures and Table from HDAC1 Upregulation by NANOG Promotes Multidrug Resistance and a Stem-like Phenotype in Immune Edited Tumor Cells
Authors: Song Kwon-Ho , Choi Chel Hun , Lee Hyo-Jung , Oh Se Jin , Woo Seon Rang , Hong Soon-Oh , Noh Kyung Hee , Cho Hanbyoul , Chung Eun Joo , Kim Jae-Hoon , Chung Joon-Yong , Hewitt Stephen M. , Baek Seungki , Lee Kyung-Mi , Yee Cassian , Son Minjoo , Mao Chih-Ping , Wu T.C. , Kim Tae Woo
Published: April 2023

Supplementary Figure 1. Immune-edited CaSki P3 cells showed a stem-like phenotype. Supplementary Figure 2. NANOG does not effect on acetylation of histone H4. Supplementary Figure 3. Expression of HDAC genes, and genes involved in negative regulators of MCL-1 protein by NANOG-HDAC1 axis. Supplementary Figure 4. The NANOG-HDAC1 axis controls immune-resistance, drug-resistance and stem-like property in multiple types of human cancer cells. Supplementary Figure 5. Generation of MDA-MB231 P3 immune-resistant cell lines. Supplementary Figure 6. Regulation of HAT genes by NANOG-HDAC1 axis. Supplementary Figure 7. Schematic interpretation of immune selection-mediated epigenetic change and implications of epigenetic therapy.
Supplemental Figure Legends from ILK Induction in Lymphoid Organs by a TNFα–NF-κB–Regulated Pathway Promotes the Development of Chronic Lymphocytic Leukemia
Authors: Krenn Peter W. , Hofbauer Sebastian W. , Pucher Susanne , Hutterer Evelyn , Hinterseer Elisabeth , Denk Ursula , Asslaber Daniela , Ganghammer Sylvia , Sternberg Christina , Neureiter Daniel , Aberger Fritz , Wickström Sara A. , Egle Alexander , Greil Richard , Hartmann Tanja N.
Published: April 2023

Supplemental Figure Legends 1-3
Supplementary Tables from LSD1-Mediated Epigenetic Reprogramming Drives CENPE Expression and Prostate Cancer Progression
Authors: Liang Yi , Ahmed Musaddeque , Guo Haiyang , Soares Fraser , Hua Junjie T. , Gao Shuai , Lu Catherine , Poon Christine , Han Wanting , Langstein Jens , Ekram Muhammad B. , Li Brian , Davicioni Elai , Takhar Mandeep , Erho Nicholas , Karnes R. Jeffrey , Chadwick Dianne , van der Kwast Theodorus , Boutros Paul C. , Arrowsmith Cheryl H. , Feng Felix Y. , Joshua Anthony M. , Zoubeidi Amina , Cai Changmeng , He Housheng H.
Published: April 2023

Table S1: Primers and siRNA sequences used in this study. Table S2-9: GO analysis of LSD1 and CENPE target genes in LNCaP and abl Cells.
Supplementary Materials and Methods from Autocrine BMP-4 Signaling Is a Therapeutic Target in Colorectal Cancer
Authors: Yokoyama Yuichiro , Watanabe Toshiaki , Tamura Yusuke , Hashizume Yoshinobu , Miyazono Kohei , Ehata Shogo
Published: April 2023

Methods for ELISA, immunoblotting, IHC, and colony formation assay.
Figure S1 from Loss of Tumor Suppressor STAG2 Promotes Telomere Recombination and Extends the Replicative Lifespan of Normal Human Cells
Authors: Daniloski Zharko , Smith Susan
Published: April 2023

Figure S1 provides a list of the STAG2 tumor cell lines used in this study and immunoblot analysis of SA1 and SA2 protein expression in the STAG2 cell lines and relates to Figure 1.
Supp Figs 1-5 from Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation
Authors: Bhagat Tushar D. , Chen Si , Bartenstein Matthias , Barlowe A. Trevor , Von Ahrens Dagny , Choudhary Gaurav S. , Tivnan Patrick , Amin Elianna , Marcondes A. Mario , Sanders Mathijs A. , Hoogenboezem Remco M. , Kambhampati Suman , Ramachandra Nandini , Mantzaris Iaonnis , Sukrithan Vineeth , Laurence Remi , Lopez Robert , Bhagat Prafulla , Giricz Orsi , Sohal Davendra , Wickrema Amittha , Yeung Cecilia , Gritsman Kira , Aplan Peter , Hochedlinger Konrad , Yu Yiting , Pradhan Kith , Zhang Jinghang , Greally John M. , Mukherjee Siddhartha , Pellagatti Andrea , Boultwood Jacqueline , Will Britta , Steidl Ulrich , Raaijmakers Marc H.G.P. , Deeg H. Joachim , Kharas Michael G. , Verma Amit
Published: April 2023

Supp Fig 1 : SFRP1 methylation with coculture Supp Fig 2 : Validation of methylation changes with stroma and leukemic cell coculture Supp Fig 3: FRZB upregulation in MDS stroma after 5-Azacytidine treatment SuppFig 4: FRZB knockdown leads to partial inhibition of erythroid differentiation induced by treatment of MDS stromawith 5-Aza SuppFig 5: The expression of WNT signature genes in MDS and control marrow derived CD34+ cells
Supplemental figures 1-6 from Targeting Vascular Endothelial-Cadherin in Tumor-Associated Blood Vessels Promotes T-cell–Mediated Immunotherapy
Authors: Zhao Yang , Ting Ka Ka , Li Jia , Cogger Victoria C. , Chen Jinbiao , Johansson-Percival Anna , Ngiow Shin Foong , Holst Jeff , Grau Georges , Goel Shom , Muller Thorleif , Dejana Elisabetta , McCaughan Geoff , Smyth Mark J. , Ganss Ruth , Vadas Mathew A. , Gamble Jennifer R.
Published: April 2023

Figure S1 Dose response of CD5-2 in B16F10 tumor model Figure S2 CD5-2 penetrates into endothelial cells but has no effect on proliferation, senescence and migration in vitro. Figure S3 CD5-2 does not affect tumor cell proliferation, necrosis, senescence and number of leukocytes infiltrating into the B16F10 tumor. Figure S4 CD5-2 has effects on CD8+ T cells but no effect on CD4+ T cells or NKp46+ NK cells in the MC38 tumor. Figure S5 CD5-2 increases VE-cadherin expression and regulates tight junctions pathway. Figure S6 schematic diagram of proposed effects of CD5-2 on tumor microenvironment.
Supplementary Figure S1-S5 from Acquired Immune Resistance Follows Complete Tumor Regression without Loss of Target Antigens or IFNγ Signaling
Authors: Donia Marco , Harbst Katja , van Buuren Marit , Kvistborg Pia , Lindberg Mattias F. , Andersen Rikke , Idorn Manja , Munir Ahmad Shamaila , Ellebæk Eva , Mueller Anja , Fagone Paolo , Nicoletti Ferdinando , Libra Massimo , Lauss Martin , Hadrup Sine Reker , Schmidt Henrik , Andersen Mads Hald , thor Straten Per , Nilsson Jonas A. , Schumacher Ton N. , Seliger Barbara , Jönsson Göran , Svane Inge Marie
Published: April 2023

This file contains Supplementary Figures presenting additional information on the immunology and tumor biology of the patient case
Supplemental Figure 3 from Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis
Authors: Tang Yun-Chi , Yuwen Hui , Wang Kaiying , Bruno Peter M. , Bullock Kevin , Deik Amy , Santaguida Stefano , Trakala Marianna , Pfau Sarah J. , Zhong Na , Huang Tao , Wang Lan , Clish Clary B. , Hemann Michael T. , Amon Angelika
Published: April 2023

DL-PDMP treatment does not cause weight loss in mice.
Supplementary Materials and Methods from Integrative Comparison of mRNA Expression Patterns in Breast Cancers from Caucasian and Asian Americans with Implications for Precision Medicine
Authors: Shi Yanxia , Steppi Albert , Cao Ye , Wang Jianan , He Max M. , Li Liren , Zhang Jinfeng
Published: April 2023

Additional detail on the Materials and Methods used. Contains information on how we controlled False Discovery Rates, a brief description of Gene Set Enrichment Analysis, and justification for our use of Gene Expression Network Analysis.
Fig. S4-S6 from Optimized Dosing Schedule Based on Circadian Dynamics of Mouse Breast Cancer Stem Cells Improves the Antitumor Effects of Aldehyde Dehydrogenase Inhibitor
Authors: Matsunaga Naoya , Ogino Takashi , Hara Yukinori , Tanaka Takahiro , Koyanagi Satoru , Ohdo Shigehiro
Published: April 2023

Supplementary Fig. 4 shows the transcriptional regulation of Aldh3a1 gene by Wnt/β-catenin signal. Supplementary Fig. 5 shows the reparation of Aldh3a1::Luc-expressing 4T1 cells. Supplementary Fig. 6 shows the comparison of mRNA levels of genes encoding Wnt ligands between ALDH-positive and negative 4T1 cells.
Supplementary Table S7 from Sex Differences in Cancer Driver Genes and Biomarkers
Authors: Li Constance H. , Haider Syed , Shiah Yu-Jia , Thai Kevin , Boutros Paul C.
Published: April 2023

Description of all validation data, sources, and results
Supplementary Table S6 from Sex Differences in Cancer Driver Genes and Biomarkers
Authors: Li Constance H. , Haider Syed , Shiah Yu-Jia , Thai Kevin , Boutros Paul C.
Published: April 2023

All point mutation results
Figure S1 from Heterozygosity of Chaperone Grp78 Reduces Intestinal Stem Cell Regeneration Potential and Protects against Adenoma Formation
Authors: van Lidth de Jeude Jooske F. , Spaan Claudia N. , Meijer Bartolomeus J. , Smit Wouter L. , Soeratram Tanya T.D. , Wielenga Mattheus C.B. , Westendorp B. Florien , Lee Amy S. , Meisner Sander , Vermeulen Jacqueline L.M. , Wildenberg Manon E. , van den Brink Gijs R. , Muncan Vanesa , Heijmans Jarom
Published: April 2023

Supplementary Figure S1
Figure S1-17, Table S1 and S2 from SNHG6 Acts as a Genome-Wide Hypomethylation Trigger via Coupling of miR-1297–Mediated S-Adenosylmethionine–Dependent Positive Feedback Loops
Authors: Guo Tao , Wang Hongling , Liu Pengpeng , Xiao Yushao , Wu Ping , Wang Yitao , Chen Baiyang , Zhao Qiu , Liu Zhisu , Liu Quanyan
Published: April 2023

We investigated the change of Genome-wide methylation patterns, DNA methylation patterns, miR-1297 expression after SNHG6 knockdown or overexpression in hepatoma cells. q-PCR was performed to simultaneously detect MAT1A mRNA in the nucleus and cytoplasm after FUS overexpression in Huh7 and Hep3B cells. RIP with q-PCR analysis was utilized to verify the direct interaction between the FUS protein and MAT1A mRNA. RNA FISH was used to study the subcellular localization and visual molecular abundance of SNHG6, miR-1297, FUS mRNA and MAT2A mRNA in Huh7 and Hep3B cells.We also identified that miR-1297 inhibits FUS expression by binding to its 3'UTR.
Supplementary Data from Targeting Mechanoresponsive Proteins in Pancreatic Cancer: 4-Hydroxyacetophenone Blocks Dissemination and Invasion by Activating MYH14
Authors: Surcel Alexandra , Schiffhauer Eric S. , Thomas Dustin G. , Zhu Qingfeng , DiNapoli Kathleen T. , Herbig Maik , Otto Oliver , West-Foyle Hoku , Jacobi Angela , Kräter Martin , Plak Katarzyna , Guck Jochen , Jaffee Elizabeth M. , Iglesias Pablo A. , Anders Robert A. , Robinson Douglas N.
Published: April 2023

Supplemental materials include following: Supplemental Materials and Methods Table S1. NMII Concentration (n), nM Fig. S1. Model systems to human pancreatic cancer. Fig. S2. Scoring analysis and differential expression patterns of mechanoresponsive and non-mechanoresponsive paralogs in patient-derived IHC data. Fig. S3: Measurement of endogenous expression of nonmuscle myosin II paralogs and the effect of knockdown, overexpression, and 4-HAP treatment on the expression of mechanobiome proteins. Fig. S4. Pancreatic cancer cell lines are mechanically distinct from each other. Fig. S5: Method for quantifying actin structures at the cellular cortex. Fig. S6: 4-HAP decreases actin retrograde flow. Fig. S7: 4-HAP treated livers show reduced surface tumor coverage. Movie S1. Retrograde flow of an untreated AsPC-1 Sir-Act-stained cell. Movie S2. Retrograde flow of a 4-HAP-treated AsPC-1 Sir-Act-stained cell.
Table S2 from MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer
Authors: Seo Jae Ho , Chae Young Chan , Kossenkov Andrew V. , Lee Yu Geon , Tang Hsin-Yao , Agarwal Ekta , Gabrilovich Dmitry I. , Languino Lucia R. , Speicher David W. , Shastrula Prashanth K. , Storaci Alessandra Maria , Ferrero Stefano , Gaudioso Gabriella , Caroli Manuela , Tosi Davide , Giroda Massimo , Vaira Valentina , Rebecca Vito W. , Herlyn Meenhard , Xiao Min , Fingerman Dylan , Martorella Alessandra , Skordalakes Emmanuel , Altieri Dario C.
Published: April 2023

Mutant peptides derived from MFF1 peptide #8 used in this study
Supplementary Figure S3 from MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer
Authors: Seo Jae Ho , Chae Young Chan , Kossenkov Andrew V. , Lee Yu Geon , Tang Hsin-Yao , Agarwal Ekta , Gabrilovich Dmitry I. , Languino Lucia R. , Speicher David W. , Shastrula Prashanth K. , Storaci Alessandra Maria , Ferrero Stefano , Gaudioso Gabriella , Caroli Manuela , Tosi Davide , Giroda Massimo , Vaira Valentina , Rebecca Vito W. , Herlyn Meenhard , Xiao Min , Fingerman Dylan , Martorella Alessandra , Skordalakes Emmanuel , Altieri Dario C.
Published: April 2023

Peptidyl mimicry of MFF-VDAC1 complex
Supplementary Data from MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer
Authors: Seo Jae Ho , Chae Young Chan , Kossenkov Andrew V. , Lee Yu Geon , Tang Hsin-Yao , Agarwal Ekta , Gabrilovich Dmitry I. , Languino Lucia R. , Speicher David W. , Shastrula Prashanth K. , Storaci Alessandra Maria , Ferrero Stefano , Gaudioso Gabriella , Caroli Manuela , Tosi Davide , Giroda Massimo , Vaira Valentina , Rebecca Vito W. , Herlyn Meenhard , Xiao Min , Fingerman Dylan , Martorella Alessandra , Skordalakes Emmanuel , Altieri Dario C.
Published: April 2023

Complete Supplementary Data with Figures embedded
Figure S5 from Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma
Authors: Jung Jinkyu , Zhang Ying , Celiku Orieta , Zhang Wei , Song Hua , Williams Brian J. , Giles Amber J. , Rich Jeremy N. , Abounader Roger , Gilbert Mark R. , Park Deric M.
Published: April 2023

NIX-mediated mitophagy is related with hypoxia-induced macroautophagy.
Figure S3 from ID1 Is Critical for Tumorigenesis and Regulates Chemoresistance in Glioblastoma
Authors: Sachdeva Rohit , Wu Megan , Smiljanic Sandra , Kaskun Oleksandra , Ghannad-Zadeh Kimia , Celebre Angela , Isaev Keren , Morrissy A. Sorana , Guan Jennifer , Tong Jiefei , Chan Jeffrey , Wilson Taylor M. , Al-Omaishi Sayf , Munoz David G. , Dirks Peter B. , Moran Michael F. , Taylor Michael D. , Reimand Jüri , Das Sunit
Published: April 2023

(A) Representative H&E images of control and ID1 KO mouse brains. (B) ID1 KO mice demonstrated greater accumulation of TMEM within the brain tissues compared to control animals. TMEM-positive cells were diffusely distributed throughout the brain, while in the control group. The boxes indicate the areas shown at higher magnification. (C) Quantification of positive TMEM cells in the brain relative to area. **P<0.005 Western blot analysis shows successful gene knockout clone for ID1 protein expression in (D) MDA-MB231 and (E) A375 cells.
Supplementary information from Follistatin-like Protein 1 Inhibits Lung Cancer Metastasis by Preventing Proteolytic Activation of Osteopontin
Authors: Chiou Jean , Chang Yu-Chan , Tsai Hsing-Fang , Lin Yuan-Feng , Huang Ming-Shyan , Yang Chih-Jen , Hsiao Michael
Published: April 2023

Supplementary material and methods; Supplementary Table 1. Additional background information of CL1-0 and CL1-5 cells; Supplementary Table 2. Mass spectrometric analysis of FSTL1-interacting protein in CL1-5/FSTL1 conditioned medium; Supplementary Table 3. Association between FSTL1 expression and clinical pathological characteristics in patients. Supplementary Figure 1. The RNA expression level of FST family members in lung cancer clinical cohort; Supplementary Figure 2. The protein expression level of FSTL1 protein family in LUAD cell lines; Supplementary Figure 3. Confirmation and functional assays of the knockdown of FSTL1 in CL1-0 and PC14 cells; Supplementary Figure 4. Confirmation and functional assays of the overexpression of FSTL1 in CL1-5 and A549 cells; Supplementary Figure 5. FSTL1 did not alter cell proliferation rates in LUAD cells; Supplementary Figure 6. rhFSTL1 inhibited metastasis of lung cancer in orthotopic model; Supplementary Figure 7. FSTL1 administration effectively inhibits metastatic progression of malignant LUAD cells; Supplementary Figure 8. Migration assay of FSTL1 antibody treated CL1-0 cells with different signaling inhibitors; Supplementary Figure 9. Reduced mRNA expression of FSTL1 correlated with a poor prognosis in patients with breast cancer.
Supplementary Information from Direct Targeting of MYCN Gene Amplification by Site-Specific DNA Alkylation in Neuroblastoma
Authors: Yoda Hiroyuki , Inoue Takahiro , Shinozaki Yoshinao , Lin Jason , Watanabe Takayoshi , Koshikawa Nobuko , Takatori Atsushi , Nagase Hiroki
Published: April 2023

Supplementary Materials and Methods and Supplementary Figure Legends
Figure S6 from Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival
Authors: Moore Paul C. , Qi Jenny Y. , Thamsen Maike , Ghosh Rajarshi , Peng Justin , Gliedt Micah J. , Meza-Acevedo Rosa , Warren Rachel E. , Hiniker Annie , Kim Grace E. , Maly Dustin J. , Backes Bradley J. , Papa Feroz R. , Oakes Scott A.
Published: April 2023

Effects of KIRA8 and GSK-PKI on RT2 tumors
Figure S7 from Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861
Authors: Pedrosa Ana-Rita , Bodrug Natalia , Gomez-Escudero Jesus , Carter Edward P. , Reynolds Louise E. , Georgiou Paraskivi Natalia , Fernandez Isabelle , Lees Delphine M. , Kostourou Vassiliki , Alexopoulou Annika N. , Batista Silvia , Tavora Bernardo , Serrels Bryan , Parsons Maddy , Iskratsch Thomas , Hodivala-Dilke Kairbaan M.
Published: April 2023

Supplementary Figure 7. Loss of endothelial cell FAK-Y397 or FAK-Y861-phosphorylation does not affect total levels of β1 Integrin, but affects clustering at focal contact sites.
Figure S6 from Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861
Authors: Pedrosa Ana-Rita , Bodrug Natalia , Gomez-Escudero Jesus , Carter Edward P. , Reynolds Louise E. , Georgiou Paraskivi Natalia , Fernandez Isabelle , Lees Delphine M. , Kostourou Vassiliki , Alexopoulou Annika N. , Batista Silvia , Tavora Bernardo , Serrels Bryan , Parsons Maddy , Iskratsch Thomas , Hodivala-Dilke Kairbaan M.
Published: April 2023

Supplementary Figure 6. Knocking down Ang-2 in B16F0s cells ablates angiogenic response in ECCre+;FAKY861F/Y861F mice in vivo.
Supplementary Figure 1 from Disruption of the Rbm38-eIF4E Complex with a Synthetic Peptide Pep8 Increases p53 Expression
Authors: Lucchesi Christopher A. , Zhang Jin , Ma Buyong , Chen Mingyi , Chen Xinbin
Published: April 2023

Pep8 reduces the Rbm38-eIF4E complex.
Table S1 from Chemotherapy-Induced Extracellular Vesicle miRNAs Promote Breast Cancer Stemness by Targeting ONECUT2
Authors: Shen Meng , Dong Chuan , Ruan Xianhui , Yan Wei , Cao Minghui , Pizzo Donald , Wu Xiwei , Yang Lin , Liu Liang , Ren Xiubao , Wang Shizhen Emily
Published: April 2023

Information of key biological reagents
Figure S20 from Cancer Exacerbates Chemotherapy-Induced Sensory Neuropathy
Authors: Housley Stephen N. , Nardelli Paul , Carrasco Dario I. , Rotterman Travis M. , Pfahl Emily , Matyunina Lilya V. , McDonald John F. , Cope Timothy C.
Published: April 2023

Effects of physiologic compensation in ApcWT+control and ApcPirc/++OX neurons.
Supplementary Figure s1 from AQP4 Aggregation State Is a Determinant for Glioma Cell Fate
Authors: Simone Laura , Pisani Francesco , Mola Maria G. , De Bellis Manuela , Merla Giuseppe , Micale Lucia , Frigeri Antonio , Vescovi Angelo L. , Svelto Maria , Nicchia Grazia P.
Published: April 2023

Supplementary Figure s1. M23-AQP4 C-terminus analysis for the ability to induce morphological changes in glioma cells. a) Schematic representation of the untagged and mCherry-tagged M23-AQP4 isoforms used for the analysis in (b). b) Immuno fluorescence analysis of U87 and U251 cells transfected with tagged and untagged M23-AQP4 isoforms. AQP4 (red) and Phallodin (green) to visualize F-actin. No morphological changes were induced by M23-AQP4 when M23-AQP4 with mCherry tagged C-terminus was used. Scale bar 50 µm. c) Quantification analysis of morphological alterations observed in the experiments described in (a). The histobar shows the percentage of cells with altered morphology. Values are expressed as mean {plus minus} SEM of % of cells with altered cell morphology on the total number of transfected cells per field (**** P<0.0001; *** P<0.0005; n=3).
Table S1 from Enhanced Fatty Acid Scavenging and Glycerophospholipid Metabolism Accompany Melanocyte Neoplasia Progression in Zebrafish
Authors: Henderson Fiona , Johnston Hannah R. , Badrock Andrew P. , Jones Emrys A. , Forster Duncan , Nagaraju Raghavendar T. , Evangelou Christos , Kamarashev Jivko , Green Michael , Fairclough Michael , Ramirez Irene Barinaga-Rementeria , He Shuning , Snaar-Jagalska B. Ewa , Hollywood Katherine , Dunn Warwick B. , Spaink Herman P. , Smith Michael P. , Lorigan Paul , Claude Emmanuelle , Williams Kaye J. , McMahon Adam W. , Hurlstone Adam
Published: April 2023

From microarray analyses, genes from BRAFV600E, V12RAS RGP, or V12RAS VGP, whose transcripts are significantly up- or down regulated when compared to wild-type tissue.
Figure S1 from HER2 CAR-T Cells Eradicate Uveal Melanoma and T-cell Therapy–Resistant Human Melanoma in IL2 Transgenic NOD/SCID IL2 Receptor Knockout Mice
Authors: Forsberg Elin M.V. , Lindberg Mattias F. , Jespersen Henrik , Alsén Samuel , Bagge Roger Olofsson , Donia Marco , Svane Inge Marie , Nilsson Ola , Ny Lars , Nilsson Lisa M. , Nilsson Jonas A.
Published: April 2023

HER2 RNA expression in TCGA and HER2 protein expression in PDX models
Supplementary Figure 4 from Hispanic/Latino Patients with Gastric Adenocarcinoma Have Distinct Molecular Profiles Including a High Rate of Germline CDH1 Variants
Authors: Wang Sam C. , Yeu Yunku , Hammer Suntrea T.G. , Xiao Shu , Zhu Min , Hong Changjin , Clemenceau Jean R. , Yoon Lynn Y. , Nassour Ibrahim , Shen Jeanne , Agarwal Deepak , Reznik Scott I. , Mansour John C. , Yopp Adam C. , Zhu Hao , Hwang Tae Hyun , Porembka Matthew R.
Published: April 2023

a. Chromatograms confirming germline CDH1 mutations identified on whole-exome sequencing. b. Age of patients who are wild-type for CDH1 (blue) or carry germline CDH1 mutations (red). Bar denotes median.
Figure S3 from A Versatile ES Cell–Based Melanoma Mouse Modeling Platform
Authors: Bok Ilah , Vera Olga , Xu Xiaonan , Jasani Neel , Nakamura Koji , Reff Jordan , Nenci Arianna , Gonzalez Jose G. , Karreth Florian A.
Published: April 2023

This Figure shows additional data highlighting the advantages of using CRISPR for gene deletion in vivo.
Supplementary Data from Hispanic/Latino Patients with Gastric Adenocarcinoma Have Distinct Molecular Profiles Including a High Rate of Germline CDH1 Variants
Authors: Wang Sam C. , Yeu Yunku , Hammer Suntrea T.G. , Xiao Shu , Zhu Min , Hong Changjin , Clemenceau Jean R. , Yoon Lynn Y. , Nassour Ibrahim , Shen Jeanne , Agarwal Deepak , Reznik Scott I. , Mansour John C. , Yopp Adam C. , Zhu Hao , Hwang Tae Hyun , Porembka Matthew R.
Published: April 2023

Supplementary Table Legend
Supplementary Table S1 from Resolution of Spatial and Temporal Heterogeneity in Bevacizumab-Treated Breast Tumors by Eigenspectra Multispectral Optoacoustic Tomography
Authors: Liapis Evangelos , Klemm Uwe , Karlas Angelos , Reber Josefine , Ntziachristos Vasilis
Published: April 2023

Supplementary Table S1
Supplementary Figure S6 from Resolution of Spatial and Temporal Heterogeneity in Bevacizumab-Treated Breast Tumors by Eigenspectra Multispectral Optoacoustic Tomography
Authors: Liapis Evangelos , Klemm Uwe , Karlas Angelos , Reber Josefine , Ntziachristos Vasilis
Published: April 2023

Supplementary Figure S6
Supplementary Figures from Targeting Pan-ETS Factors Inhibits Melanoma Progression
Authors: Huang Lee , Zhai Yougang , La Jennifer , Lui Jason W. , Moore Stephen P.G. , Little Elizabeth C. , Xiao Sixia , Haresi Adil J. , Brem Candice , Bhawan Jag , Lang Deborah
Published: April 2023

Supplementary figures S1, S2, and S3
Figure S5 from Targeting Obesity-Induced Macrophages during Preneoplastic Growth Promotes Mammary Epithelial Stem/Progenitor Activity, DNA Damage, and Tumor Formation
Authors: Chamberlin Tamara , Clack Megan , Silvers Caylee , Kuziel Genevra , Thompson Victoria , Johnson Haley , Arendt Lisa M.
Published: April 2023

Figure S5 shows DNA damage in p53-/- primary epithelial cells following treatment with hydrogen peroxide.
Supplementary Figure S8 from Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression
Authors: Barnabas Georgina D. , Lee Joo Sang , Shami Tamar , Harel Michal , Beck Lir , Selitrennik Michael , Jerby-Arnon Livnat , Erez Neta , Ruppin Eytan , Geiger Tamar
Published: April 2023

Supplementary Figure S8. Proteomic and functional effects mediated by PHGDH and PSAT in IDH2 A - Profile plot shows the proteins that are upregulated with IDH2 overexpression compared to control cells and downregulated with PHGDH and PSAT1 knockouts in HCC38. The proteins are ANOVA significant with FDR 0.05. B - Protein interaction network of PHGDH and PSAT1 regulated ANOVA significant proteins. Proteins involved in metabolism, translation machinery, ribosome biogenesis, splicing and cell migration were influenced by PHGDH and PSAT1 in IDH2 cells. C - Loss of PHGDH and PSAT1 renders IDH2-high HCC38 cells more sensitive to oxidative stress (treatment with 25μM H2O2) (*p-value <0.05 and **p-value <0.01). No differences are seen in the control mCherry overexpressing cells. D - Schematic model depicting the metabolic effects of IDH2, mediated by PHGDH and PSAT1 in breast cancer cells. E-F - Serine biosynthesis pathway was traced using 13C6-glucose labeling upon NCT-502 treatment in the HCC38 cells with IDH2 overexpression (E) and HCC1143 cells with IDH2 knockout (F). Abundance of serine (m3) was reduced upon NCT-502 treatment. G-H - Reduced abundance of glycine (m2) with NCT-502 treatment in the HCC38 cells with IDH2 overexpression (G) and HCC1143 cells with IDH2 knockout (H) (*p-value <0.05). I - Western blot shows shRNA-mediated knockdown of IDH2 in the 4T1 breast cancer cells. J - Design of an in vivo experiment to evaluate the efficacy of the PHGDH inhibitor in IDH2 high and low orthotopic xenografts. K - IDH2 expression levels in the 4T1 tumors with control and IDH2 knockout.
Supplementary Figure S5 from Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression
Authors: Barnabas Georgina D. , Lee Joo Sang , Shami Tamar , Harel Michal , Beck Lir , Selitrennik Michael , Jerby-Arnon Livnat , Erez Neta , Ruppin Eytan , Geiger Tamar
Published: April 2023

Supplementary Figure S5. Increased serine synthesis as predicted by MOMA analysis in IDH2 overexpression A - Western blot shows PHGDH and PSAT1 expression increases upon IDH2 overexpression and reduced in the knockout cells, while no difference in the PHGDH and PSAT1 expression was observed in the cells with transient-IDH2 overexpression. B - Proteomic analysis of PHGDH, PSAT1 and PSPH in the IDH2 perturbed cells, LFQ, label-free quantification. C-D - Increased abundance of Serine (m3) and glycine (m2) from 13C6-glucose labeling with transient IDH2 overexpression. E - Fraction of serine (m3) and glycine (m2) from 13C6-glucose in the IDH2 perturbed cells. F - Basal levels of Serine (m3) correlate with endogenous IDH2 expression. (*p-value <0.05; **p-value <0.01).
Figure S2 from Targeting Obesity-Induced Macrophages during Preneoplastic Growth Promotes Mammary Epithelial Stem/Progenitor Activity, DNA Damage, and Tumor Formation
Authors: Chamberlin Tamara , Clack Megan , Silvers Caylee , Kuziel Genevra , Thompson Victoria , Johnson Haley , Arendt Lisa M.
Published: April 2023

Figure S2 shows additional characterization of end stage tumors.
Supp Materials and Methods from A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors
Authors: Barnoud Thibaut , Leung Jessica C. , Leu Julia I-Ju , Basu Subhasree , Poli Adi Narayana Reddy , Parris Joshua L.D. , Indeglia Alexandra , Martynyuk Tetyana , Good Madeline , Gnanapradeepan Keerthana , Sanseviero Emilio , Moeller Rebecca , Tang Hsin-Yao , Cassel Joel , Kossenkov Andrew V. , Liu Qin , Speicher David W. , Gabrilovich Dmitry I. , Salvino Joseph M. , George Donna L. , Murphy Maureen E.
Published: April 2023

Supp Materials and Methods
Supplementary method from Psychiatric Disorders Are Associated with Increased Risk of Sepsis Following a Cancer Diagnosis
Authors: Liu Qianwei , Song Huan , Andersson Therese M.-L. , Magnusson Patrik K.E. , Zhu Jianwei , Smedby Karin E. , Fang Fang
Published: April 2023

Supplementary method describes details of statistical models, including effect of covariates and degrees of freedom.
Supplementary Tables S1-S2 from Psychiatric Disorders Are Associated with Increased Risk of Sepsis Following a Cancer Diagnosis
Authors: Liu Qianwei , Song Huan , Andersson Therese M.-L. , Magnusson Patrik K.E. , Zhu Jianwei , Smedby Karin E. , Fang Fang
Published: April 2023

Table S1: ICD-10 codes for cancer. Table S2: ICD-10 codes for sepsis and infection.
Supplementary Table 2 from Loss of ARID1A Promotes Epithelial–Mesenchymal Transition and Sensitizes Pancreatic Tumors to Proteotoxic Stress
Authors: Tomihara Hideo , Carbone Federica , Perelli Luigi , Huang Justin K. , Soeung Melinda , Rose Johnathon L. , Robinson Frederick S. , Lissanu Deribe Yonathan , Feng Ningping , Takeda Mitsunobu , Inoue Akira , Poggetto Edoardo Del , Deem Angela K. , Maitra Anirban , Msaouel Pavlos , Tannir Nizar M. , Draetta Giulio F. , Viale Andrea , Heffernan Timothy P. , Bristow Christopher A. , Carugo Alessandro , Genovese Giannicola
Published: April 2023

GSEA analysis
Supplementary Legends from Loss of ARID1A Promotes Epithelial–Mesenchymal Transition and Sensitizes Pancreatic Tumors to Proteotoxic Stress
Authors: Tomihara Hideo , Carbone Federica , Perelli Luigi , Huang Justin K. , Soeung Melinda , Rose Johnathon L. , Robinson Frederick S. , Lissanu Deribe Yonathan , Feng Ningping , Takeda Mitsunobu , Inoue Akira , Poggetto Edoardo Del , Deem Angela K. , Maitra Anirban , Msaouel Pavlos , Tannir Nizar M. , Draetta Giulio F. , Viale Andrea , Heffernan Timothy P. , Bristow Christopher A. , Carugo Alessandro , Genovese Giannicola
Published: April 2023

Legends of Supplementary Figures and Tables
Supplementary Figure 1 from Loss of ARID1A Promotes Epithelial–Mesenchymal Transition and Sensitizes Pancreatic Tumors to Proteotoxic Stress
Authors: Tomihara Hideo , Carbone Federica , Perelli Luigi , Huang Justin K. , Soeung Melinda , Rose Johnathon L. , Robinson Frederick S. , Lissanu Deribe Yonathan , Feng Ningping , Takeda Mitsunobu , Inoue Akira , Poggetto Edoardo Del , Deem Angela K. , Maitra Anirban , Msaouel Pavlos , Tannir Nizar M. , Draetta Giulio F. , Viale Andrea , Heffernan Timothy P. , Bristow Christopher A. , Carugo Alessandro , Genovese Giannicola
Published: April 2023

Supplementary Figure 1. Characterization of 23 PDAC cell lines.
Figure S10 from Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells
Authors: Alvarez-Trotta Annamil , Guerrant William , Astudillo Luisana , Lahiry Mohini , Diluvio Giulia , Shersher Elena , Kaneku Hugo , Robbins David J. , Orton Darren , Capobianco Anthony J.
Published: April 2023

Sorting of EAC47 cells by ALDH expression
Table S1 from Targeting Pyruvate Kinase M2 Phosphorylation Reverses Aggressive Cancer Phenotypes
Authors: Apostolidi Maria , Vathiotis Ioannis A. , Muthusamy Viswanathan , Gaule Patricia , Gassaway Brandon M. , Rimm David L. , Rinehart Jesse
Published: April 2023

PKM2 gene expression analysis in TCGA Pan-Cancer database.
Data from Phosphotyrosine Signaling Analysis in Human Tumors Is Confounded by Systemic Ischemia-Driven Artifacts and Intra-Specimen Heterogeneity
Authors: Gajadhar Aaron S. , Johnson Hannah , Slebos Robbert J.C. , Shaddox Kent , Wiles Kerry , Washington Mary Kay , Herline Alan J. , Levine Douglas A. , Liebler Daniel C. , White Forest M.
Published: April 2023

Abstract
Tumor protein phosphorylation analysis may provide insight into intracellular signaling networks underlying tumor behavior, revealing diagnostic, prognostic or therapeutic information. Human tumors collected by The Cancer Genome Atlas program potentially offer the opportunity to characterize activated networks driving tumor progression, in parallel with the genetic and transcriptional landscape already documented for these tumors. However, a critical question is whether cellular signaling networks can be reliably analyzed in surgical specimens, where freezing delays and spatial sampling disparities may potentially obscure physiologic signaling. To quantify the extent of these effects, we analyzed the stability of phosphotyrosine (pTyr) sites in ovarian and colon tumors collected under conditions of controlled ischemia and in the context of defined intratumoral sampling. Cold-ischemia produced a rapid, unpredictable, and widespread impact on tumor pTyr networks within 5 minutes of resection, altering up to 50% of pTyr sites by more than 2-fold. Effects on adhesion and migration, inflammatory response, proliferation, and stress response pathways were recapitulated in both ovarian and colon tumors. In addition, sampling of spatially distinct colon tumor biopsies revealed pTyr differences as dramatic as those associated with ischemic times, despite uniform protein expression profiles. Moreover, intratumoral spatial heterogeneity and pTyr dynamic response to ischemia varied dramatically between tumors collected from different patients. Overall, these findings reveal unforeseen phosphorylation complexity, thereby increasing the difficulty of extracting physiologically relevant pTyr signaling networks from archived tissue specimens. In light of this data, prospective tumor pTyr analysis will require appropriate sampling and collection protocols to preserve in vivo signaling features. Cancer Res; 75(7); 1495–503. ©2015 AACR.
Data from Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB–Controlled Oxidative Stress Responses
Authors: Shono Yusuke , Tuckett Andrea Z. , Liou Hsiou-Chi , Doubrovina Ekaterina , Derenzini Enrico , Ouk Samedy , Tsai Jennifer J. , Smith Odette M. , Levy Emily R. , Kreines Fabiana M. , Ziegler Carly G.K. , Scallion Mary I. , Doubrovin Mikhail , Heller Glenn , Younes Anas , O'Reilly Richard J. , van den Brink Marcel R.M. , Zakrzewski Johannes L.
Published: April 2023

Abstract
NF-κB plays a variety of roles in oncogenesis and immunity that may be beneficial for therapeutic targeting, but strategies to selectively inhibit NF-κB to exert antitumor activity have been elusive. Here, we describe IT-901, a bioactive naphthalenethiobarbiturate derivative that potently inhibits the NF-κB subunit c-Rel. IT-901 suppressed graft-versus-host disease while preserving graft-versus-lymphoma activity during allogeneic transplantation. Further preclinical assessment of IT-901 for the treatment of human B-cell lymphoma revealed antitumor properties in vitro and in vivo without restriction to NF-κB–dependent lymphoma. This nondiscriminatory, antilymphoma effect was attributed to modulation of the redox homeostasis in lymphoma cells resulting in oxidative stress. Moreover, NF-κB inhibition by IT-901 resulted in reduced stimulation of the oxidative stress response gene heme oxygenase-1, and we demonstrated that NF-κB inhibition exacerbated oxidative stress induction to inhibit growth of lymphoma cells. Notably, IT-901 did not elicit increased levels of reactive oxygen species in normal leukocytes, illustrating its cancer selective properties. Taken together, our results provide mechanistic insight and preclinical proof of concept for IT-901 as a novel therapeutic agent to treat human lymphoid tumors and ameliorate graft-versus-host disease. Cancer Res; 76(2); 377–89. ©2016 AACR.
Supplementary Table 3 from Oral Contraceptive Use and Risk of Breast, Cervical, Colorectal, and Endometrial Cancers: A Systematic Review
Authors: Gierisch Jennifer M. , Coeytaux Remy R. , Urrutia Rachel Peragallo , Havrilesky Laura J. , Moorman Patricia G. , Lowery William J. , Dinan Michaela , McBroom Amanda J. , Hasselblad Vic , Sanders Gillian D. , Myers Evan R.
Published: April 2023

PDF - 142 KB, Study characteristics and association between OC use and colorectal cancer incidence.
Supplementary Table 2 from Oral Contraceptive Use and Risk of Breast, Cervical, Colorectal, and Endometrial Cancers: A Systematic Review
Authors: Gierisch Jennifer M. , Coeytaux Remy R. , Urrutia Rachel Peragallo , Havrilesky Laura J. , Moorman Patricia G. , Lowery William J. , Dinan Michaela , McBroom Amanda J. , Hasselblad Vic , Sanders Gillian D. , Myers Evan R.
Published: April 2023

PDF - 143KB, Study characteristics and association between OC use and cervical cancer incidence.
Supplementary Table from The Epidemic of Non–Hodgkin Lymphoma in the United States: Disentangling the Effect of HIV, 1992–2009
Authors: Shiels Meredith S. , Engels Eric A. , Linet Martha S. , Clarke Christina A. , Li Jianmin , Hall H. Irene , Hartge Patricia , Morton Lindsay M.
Published: April 2023

Supplementary Table - PDF file 46K, NHL rates excluding persons with HIV with 1) the SEER population as the denominator; 2) the SEER population excluding persons with AIDS as the denominator; and 3) the SEER population excluding persons with HIV as the denominator, 2006-2009.
Supplementary Figure 5 from Sex Disparities in Cancer Mortality and Survival
Authors: Cook Michael B. , McGlynn Katherine A. , Devesa Susan S. , Freedman Neal D. , Anderson William F.
Published: April 2023

PDF file - 102K
Supplementary Tables 1 through 5 from Childhood Height and Birth Weight in Relation to Future Prostate Cancer Risk: A Cohort Study Based on the Copenhagen School Health Records Register
Authors: Cook Michael B. , Gamborg Michael , Aarestrup Julie , Sørensen Thorkild I.A. , Baker Jennifer L.
Published: April 2023

PDF - 76KB, Supplementary Table 1. Birth weight and height of boys by age of assessment and by birth cohort. Supplementary Table 2. Hazard ratios of prostate cancer in adulthood per 1 kg in birth weight or per 5 cm in height. Supplementary Table 3. Test of proportional hazards assumption by inclusion of a time (age) varying effect of birth weight/childhood height on the risk of prostate cancer, measured as hazard ratio per z-score, in Cox proportional hazards regression models. Supplementary Table 4. Test of proportional hazards assumption by inclusion of a time (age) - birth weight/height z-score cross product term in Cox proportional hazards regression models. Age is divided into quartiles. Supplementary Table 5. Hazard ratios of prostate cancer in adulthood per increase in age-specific height z-score restricted to those with birth weight measures, unadjusted and adjusted for birth weight.
Supplementary Figure 35 from Sex Disparities in Cancer Mortality and Survival
Authors: Cook Michael B. , McGlynn Katherine A. , Devesa Susan S. , Freedman Neal D. , Anderson William F.
Published: April 2023

PDF file - 99K