bluuebunny/crossref_metadata_2025 huggingface dataset:
The Illogical Logics of America’s Wars in the Middle East: Vietnam and Iraq
Authors: Attia Sarah
Published: October 2023

Introduction: Describing the US wars in Vietnam and Iraq, many critics assert the similarity between US decision making in both wars. The critics of U.S. administration often link between Iraq and Vietnam, charging George W. Bush and his policy makers that they had rejected the lessons of Vietnam War 1965–73 and involved the country in a similar kind of conflict. Purpose: This study aims to draw parallels between Iraq and Vietnam wars which mainly center on the role of misinformation and deception in the run-up to the two wars, the political and military problems that the United States confronted in each case, and the ebbing of public support in the face of two similarly draining conflicts. Study questions: The study raises many substantive questions concerning the two wars: How did America become involved in Vietnam? How did it launch war in Iraq? What were the main motivations in both wars? What were their main aims? Did the decision makers in George W. Bush’s administration learn the lessons of Vietnam or they repeated the same mistakes? Methodology/Approach: The study depends on the analytical and comparative approaches to analyze thoroughly how USA became involved in Vietnam and Iraq, its motivations, and its aims, trying to find satisfying answers to the questions it raised.
Factors Affecting Inflation Rates in the Kingdom of Saudi Arabia: A standard study from 1980 to 2016
Authors: Al-Ofi Zakiah
Published: October 2023

This study aimed at identifying the factors affecting inflation rates in the Kingdom of Saudi Arabia for the period (1980-2016). To achieve the study purpose, the researcher adopted the descriptive analytical model as it suits this phenomenon. A group of variables that are expected to affect the inflation rate in the Saudi economy is selected. These variables are: money supply growth rate, imports of GDP, oil price growth rate, rate of exchange, income growth rate interest rate on the dollar and generate price level. Besides that, a standard model was built based on a series of data of inflation determents for the Saudi economy (1980-2016). The researcher also used the EViews program to tackle the relation among the variables and to obtain the best results. The study reached the following set of results: There is a direct relation between the inflation rate and money supply growth rate, imports of GDP, and general price level. Whereas the money supply growth rate has the strongest impact on inflation followed by imports of GDP, on the other hand, there is an inverse relation with both exchange rate. Meanwhile, the rest of the variables, oil price growth rate, income growth rate, and interest rate on the dollar have no effect on the inflation rate in Saudi Arabia.
Empfehlungen zu den angemessenen Aufwendungen für Unterkunft und Heizung im SGB II und SGB XII
Authors:   Deutscher Verein für öffentliche und private Fürsorge e.V.
Published: October 2023

Empfehlungen zu den angemessenen Aufwendungen für Unterkunft und Heizung im SGB II und SGB XII geben Hilfestellung bei der Bestimmung abstrakter Richtwerte für Wohnkosten und der konkreten Angemessenheitsprüfung im Einzelfall.
MANAJEMEN TALENTA APARATUR SIPIL NEGARA: PRAKTIK DAN PELUANG INOVASI
Authors: Walinegoro Bhakti Gusti , Fitriyono Junaidul
Published: October 2023

The talent management of the state civil apparatus is the main effort to realize a world-class state civil apparatus. In Indonesia, the practice has been carried out through various programs and stages. However, there are still obstacles that become challenges, which can actually be opportunities for innovation. This study aims to analyze the practices and opportunities for innovation of state civil apparatus talent management in Indonesia. The discussion focuses on three main scopes in talent management, namely recruitment and selection, training and development, and talent retention. The method used is descriptive qualitative. The research data comes from documents in the form of journal articles related to the research topic, such as report about state civil apparatus and trusted mass media news. The results of the analysis show that state civil apparatus talent management carried out in Indonesia is still not optimal. Therefore, it is necessary to make improvements through innovation strategies by utilizing existing potentials or opportunities. In recruitment and selection, improvements can be made by improving branding to attract potential applicants and recruiting professionals for certain positions. In training and development, improvement can be done by planning and implementing competency-based training and digitizing career development. In talent retention, improvements can be made from the aspects of leadership commitment, awarding, and career certainty.
ANALISIS KEADILAN DAN KEPASTIAN KARIER PEJABAT FUNGSIONAL MELALUI KEBIJAKAN DEMOSI JABATAN
Authors: Sudewo Perdhana Ari
Published: October 2023

Manajemen PNS di Indonesia dilaksanakan dengan sistem merit yang menekankan pada kualifikasi, kompetensi dan kinerja pegawai dalam pembinaan karier. Sistem merit dilaksanakan dengan prinsip memberikan keadilan dan kewajaran, serta kejelasan dan kepastian dalam pembinaan karier PNS, termasuk pagi Pejabat Fungsional. Meskipun demikian, dalam pelaksanaan pembinaan karier Jabatan Fungsional hanya dilaksanakan melalui promosi dan mutasi jabatan, serta penugasan. kebijakan demosi Jabatan Fungsional pada jenjang jabatan setingkat lebih rendah saat ini belum menjadi bagian dari strategi pembinaan karier Pejabat Fungsional. Kondisi tersebut berpotensi untuk menciptakan ketidakadilan dan ketidakpastian karier bagi Pejabat Fungsional, khususnya Pejabat Fungsional pada jenjang lebih rendah yang tidak dapat melakukan pengembangan karier dikarenakan ketiadaan lowongan atau formasi jabatan pada jenjang Jabatan Fungsional setingkat lebih tinggi. Ketiadaan kebijakan demosi menyebabkan Pejabat Fungsional dengan pangkat dan jabatan tertinggi dalam organisasi tidak akan diturunkan jabatannya meskipun secara kualifikasi, kinerja, maupun kompetensi dinyatakan tidak memenuhi syarat. Dengan kondisi tersebut, maka direkomendaskan untuk dikembangkan kebijakan demosi Jabatan Fungsional untuk memberikan jaminan keadilan dan kepastian karier bagi semua Pejabat Fungsional sesuai dengan sistem merit, serta upaya untuk menciptakan iklim kompetisi yang sehat antar pegawai, sekaligus memacu pegawai untuk terus meningkatkan kualifikasi, kompetensi, dan kinerja agar tidak terkena kebijakan demosi jabatan.
Peningkatan kompetensi guru SMP dalam implementasi 3 bentuk asesmen Kurikulum Merdeka
Authors: Aditama Madya , Winaryati Eny , Bagiya Bagiya , Oktaviani Sintia
Published: October 2023

Implementasi kebijakan Kurikulum Merdeka dimana salah satunya adalah penerapan asesmen dalam proses pembelajaran menuntut guru sebagai pendidik untuk terus meningkatkan kemampuan dan kompetensi pedagogi. Terlebih dalam era learning loss pasca pandemi ini yang membuat peningkatan kualitas pendidikan di Indonesia menjadi tantangan tersendiri. Kegiatan Pengabdian kepada Masyarakat yang dilakukan berupa pelatihan peningkatan kompetensi guru dalam penerapan 3 bentuk asesmen ini diikuti oleh 28 guru SMP yang berasal dari wilayah Kecamatan Tersono dan Limpung, Kabupataen Batang, Jawa Tengah. Kegiatan tersebut menggunakan metode pelatihan denagn konsep FGD dan Latihan praktik penyusunan rancangan pembelajaran. Keadaan dilapangan dimana mayoritas guru masih bingung dengan konsep dan penerapan asesmen menjadi dasar kurang efektifnya penerapan kebijakan Kurikulum Merdeka di satuan pendidikan. Kegiatan pelatihan mengenai penerapan 3 bentuk asesmen dalam pembelajaran dapat meluruskan miskonsepsi mengenai asesmen dikalangan guru serta meningkatkan kompetensi pedagogi guru dalam merancang pembelajaran yang berkualitas. Pada akhir kegiatan, menunjukkan hasil 100% peserta telah memahami dan mampu merancang pembelajaran terintegrasi 3 bentuk asesmen sebagai implementasi Kurikulum Merdeka.
The implementation of the Merdeka Curriculum policy, one of which is the application of assessment in the learning process, requires teachers as educators to continue to improve their pedagogical skills and competencies. Especially in this post-pandemic learning loss era which makes improving the quality of education in Indonesia a challenge in itself. The Community Service activity carried out in the form of training to improve teacher competence in implementing 3 forms of assessment was attended by 28 junior high school teachers from the Tersono and Limpung Districts, Batang Regency, Central Java. The activity used training methods with the concept of FGDs and practical exercises in preparing lesson plans. The situation in the field where the majority of teachers are still confused about the concept and application of assessment is the basis for the ineffective implementation of the Merdeka Curriculum policy in education units. Training activities on the application of 3 forms of assessment in learning can straighten out misconceptions about assessment among teachers and improve teachers' pedagogical competence in designing quality learning. At the end of the activity, the results showed that 100% of participants had understood and were able to design integrated learning in 3 forms of assessment as an implementation of the Merdeka Curriculum.
Muinaisruoka eläväksi
Authors: Lares Jenni
Published: October 2023

Raportti historiallisen kokkailun työpajasta Ruokahistorian tutkimuspäivien yhteydessä syyskuussa 2022.
Arkeologian harrastusyhdistykset Suomessa
Authors: Väisänen Teemu , Fast Jan
Published: October 2023

Arkeologian harrastustoiminta on kehittynyt Suomessa muinaisesineiden keräilystä ja kaivauksilla avusta-misesta entistä monimuotoisemmaksi, sisältäen muun muassa muinaisjäännösten hoitoa, julkaisutoimin-taa ja ryhmämatkailua. Etenkin 1990-luvulla yleistyneet yleisökaivaukset ovat muuttaneet arkeologianharrastamisen dynamiikkaa, sillä yleisökaivauksilla arkeologian harrastajat eivät enää vain osallistu lisä-työvoimana kaivauksille, vaan kaivaukset itsessään järjestetään heitä varten. Arkeologisen yleisötyön mo-nipuolistunut kenttä on tarjonnut edellytykset arkeologian toimintaa koordinoivien harrastusyhdistystenperustamiselle. Tässä katsauksessa perehdymme arkeologian harrastajayhdistysten historiaan, yhdistystenjärjestämään toimintaan ja yhteistyöhön arkeologien kanssa.
Mullankaivajat-hanke Menneisyyden metsästäjät Muoniossa
Authors: Kallio-Seppä Titta , Tranberg Annemari
Published: October 2023

Suomen Kulttuurirahaston rahoittama Mullankaivajat-hanke Menneisyyden metsästäjät Muoniossa järjestettiin Tornionlaakson museon alueellisen museotoiminnan vastuualueen pohjoisimmassa kunnassa Muoniossa 15.–29.8. ja 6.–9.9.2022. Hanke toteutettiin yhteistyössä Muonion yhtenäiskoulun, Muonion seurakunnan ja Oulun yliopiston kanssa. Yhteisöarkeologisella kurssilla Muonion yhtenäiskoulun 5. ja 6.-luokkien oppilaat pääsivät opettajineen tutustumaan kotiseutunsa historiaan, kotiympäristön havainnointiin ja arkeologiseen tutkimukseen laaja-alaisesti aina Muonion kivikaudesta Lapin sodan tapahtumiin saakka. Tässä artikkelissa käymme läpi hankkeen etenemistä ja sen tuloksia.
Strategi Komunikasi Organisasi Motor XTC dalam Membangun Citra Positif di Masyarakat Kota Serang
Authors: Laksana April , Ferdiana Riska , Falah Miftahul
Published: October 2023

The phenomenon of actions carried out by motorcycle organizations involves illegal racing activities that often disturb the public. The public's perception of the presence of motorcycle organizations is something very frightening. However, it is different from the XTC (Exalt to Creativity) motorcycle organization, which has obtained official legality and has become part of a community organization (Ormas), being one of the renowned and largest motorcycle organizations in Indonesia. This research employs a qualitative descriptive method. Discussion Results With the transformation of the XTC Motorcycle Organization into a community organization, various positive activity programs can contribute to the community. Although once viewed as a brutal motorcycle organization, the public does not need to worry about encountering the XTC organization because it is now heading towards a positive direction, with clear and more structured goals and is registered and recognized by the government.
Stagnasi Reformasi Administrasi (Studi Pada Program SIMPELAKU Disdukcapil di Desa Girijaya Kecamatan Cibinong Kabupaten Cianjur)
Authors: Maesaroh Dede Resa
Published: October 2023

This study aims to determine the Simpelaku Program in the implementation of Population Administration management and find out what are the inhibiting and supporting factors for the implementation of the Simpelaku Program in Girijaya Village, Cibinong District, Cianjur Regency. The method used in this research is qualitative research methods, data collection techniques using interviews, observation, as well as documentation and source triangulation. The results show that the implementation of the Simpelaku Program in Girijaya Village, Cibinong District, Cianjur Regency has been going well, it is indicated by the Girijaya Village Government supporting the Simpelaku Program by directly assisting the community in using Simpelaku online services, Although there are still obstacles in the implementation of the Simpelaku Program, such as the people of Girijaya Village, many do not understand the use of digital services, and have not been able to take advantage of technology in the form of G edget or computer, Simpelaku Program Applications often experience technical problems.
Numbers of Atlantic Puffins Fratercula arctica found on beached bird surveys in Orkney and Shetland over a 30-year period
Authors: Heubeck M , Meek E , Mellor R , Wilson M
Published: October 2023

Long-term beached bird survey data from Orkney and Shetland were examined for abnormal mortality patterns of Atlantic Puffins Fratercula arctica that coincided with decreased breeding numbers at colonies in eastern Britain. Unusually high numbers of dead Atlantic Puffins were found in the late winters of 2002/03 and 2003/04, autumn and early winter 2006, and autumn 2007, although not necessarily in both island groups at the same time. The 2007 mortality was unusual in that some adult birds were replacing their primaries.
Playback re-survey and demographic modelling indicate a substantial increase in breeding European Storm-petrels Hydrobates pelagicus at the largest UK colony, Mousa, Shetland
Authors: Bolton M , Brown J , Moncrieff H , Ratcliffe N , Okill J
Published: October 2023

The island of Mousa, Shetland, is designated as part of the European Natura 2000 reserve network as a Special Protection Area (SPA) for breeding European Storm- petrels Hydrobates pelagicus. In 1996 the population was censused using playback methods and reported as 6,800 (95% CI 4,800–8,800) apparently occupied sites (AOS), c. 26% of the UK breeding population. Re-examination of the 1996 data highlighted some calculation inaccuracies, resulting in a reduced population estimate for 1996 of 5,410 AOS (95% CI 3,932–7,022). Resurvey of the colony in 2008 using identical methods revealed a 118% increase to 11,781 AOS (95% CI 8,100–17,728). A sample of c. 90 nest sites in natural crevices has been monitored annually since 1990 to determine breeding productivity. A deterministic population model, incorporating observed annual productivity estimates, annual survival rates and age of first breeding, also indicates a population increase of similar magnitude (95%) between 1996 and 2008. The similarity in trend estimates from the two independent approaches is perhaps surprising, given the large potential sources of error associated with each, and suggests that both the playback survey method and productivity monitoring from a single annual visit provide reliable demographic estimates. The large increase in population size of European Storm- petrels contrasts starkly with the trends of many other seabird species in the region, and likely results from aspects of Procellariiform foraging and reproductive strategies that confer resilience to unpredictable and scarce food supplies.
Post-mortem examination of Great Northern Divers Gavia immer killed in the Prestige oil spill, Galicia, Spain, 2002/03
Authors: Camphuysen C , Bao R , Fortin M , Roselaar C , Heubeck M
Published: October 2023

Great Northern Divers Gavia immer collected during the impact assessment of the 2002/03 Prestige oil spill were studied and compared with similar casualties collected during three other major oil spills. It was concluded that adults tend to winter further to the north in Western Europe than juveniles, and that the sexes were evenly represented in all spills. Wing and bill lengths of adults were also compared with those of museum specimens collected during the breeding season in Canada, Greenland and Iceland in an attempt to determine the possible breeding origin of birds wintering in northwest Spain. Wing lengths suggested that Iceland and Greenland were possible breeding grounds, while the incidence of embedded gunshot (18% of adults) further suggested that at least some birds originated from Greenland, where hunting is still legal. However, biometrics and gunshot incidence alone were inconclusive in determining a possible breeding origin. DNA analyses are being considered, including comparisons with gene sequences for this species already available in the GenBank. Mortality during the Prestige oil spill may have affected 18–22% of the total wintering population in Spain. Besides oil-induced mortality, drowning in fishing gear is identified as a real threat in Galicia. A systematic beached bird survey in the region would help determine the relative importance of different causes of mortality in this species.
SIMULATION MODELING OF THE FLIGHT OF AN AIRCRAFT WITH DIFFERENT TYPES OF WINGLETS
Authors:   Ulyanovsk Civil Aviation Institute, Sorokin D.V. , Samokhina S.S.
Published: October 2023

The results of the research of a comparative analysis of the effectiveness of various types of wingtips performed by modeling (simulation and full-scale) is presented in this article.
Coral Reefs Health Level in The Local Use Zone of Lentea Island Wakatobi National Park, Indonesia
Authors: Adimu Hasan Eldin , Fauzan Tezza , Fekri Latifa , Hasidu La Ode Abdul Fajar , Tsabaramo Ilham Antariksa
Published: October 2023

Coral reefs are marine resources that are most vulnerable to disturbances from both human and natural activities. Fishing activities that are not environmentally friendly such as bombardment and potassium are still found in coastal areas and threaten the resources in the conservation area. This research will look at the health condition of coral reefs in conservation areas, especially in local utilization zones. In this zone the activity of exploiting marine resources is very high, therefore data is needed to find out and prove whether the use of marine resources is damaging. Locations were selected at four stations on Lentea Island which are included in the local use zone in the conservation area. The assessment uses the PIT (Point Intercept Transect) method. The results of the assessment showed that the coral reefs on Lentea Island were in the bad to good category (24.0% -50.3%). This data shows that there are still destructive marine resource utilization activities in the local utilization zone.
The lncRNA Malat1 Inhibits miR-15/16 to Enhance Cytotoxic T Cell Activation and Memory Cell Formation
Authors: Wheeler Benjamin D , Gagnon John D , Zhu Wandi S , Muñoz-Sandoval Priscila , Wong Simon K , Simeonov Dimitre R , Li Zhongmei , Debarge Rachel , Spitzer Matthew H , Marson Alexander , Ansel K Mark
Published: October 2023

Proper activation of cytotoxic T cells via the T cell receptor and the costimulatory receptor CD28 is essential for adaptive immunity against viruses, many intracellular bacteria and cancers. Through biochemical analysis of RNA:protein interactions, we uncovered a non-coding RNA circuit regulating activation and differentiation of cytotoxic T cells composed of the long non-coding RNA Malat1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) and the microRNA family miR-15/16. miR-15/16 is a widely and highly expressed tumor suppressor miRNA family important for cell proliferation and survival. miR-15/16 also play important roles in T cell responses to viral infection, including the regulation of antigen-specific T cell expansion and T cell memory. Comparative Argonaute-2 high throughput sequencing of crosslinking immunoprecipitation (Ago2 HITS-CLIP, or AHC) combined with gene expression profiling in normal and miR-15/16-deficient T cells revealed a large network of several hundred direct miR-15/16 target mRNAs, many with functional relevance for T cell activation, survival and memory formation. Among these targets, the long non-coding RNA Malat1 contained the largest absolute magnitude miR-15/16-dependent AHC peak in T cells. This binding site was also among the strongest lncRNA:miRNA interactions detected in the T cell transcriptome. We used CRISPR targeting with homology directed repair to generate mice with a 5-nucleotide mutation in the miR-15/16 binding site in Malat1. This mutation interrupted Malat1:miR-15/16 interaction, and enhanced the repression of other miR-15/16 target genes, including CD28. Interrupting Malat1 interaction with miR-15/16 decreased cytotoxic T cell activation, including the expression of IL-2 and a broader CD28-responsive gene program. Accordingly, Malat1 mutation diminished memory cell persistence following LCMV Armstrong and
Listeria monocytogenes
infection. This study marks a significant advance in the study of long noncoding RNAs in the immune system by ascribing cell-intrinsic, sequence-specific
in vivo
function to Malat1. These findings have implications for T cell-mediated autoimmune diseases, antiviral and anti-tumor immunity, as well as lung adenocarcinoma and other malignancies where Malat1 is overexpressed.
Predicting Ventricular Tachycardia Circuits in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy using Genotype-specific Heart Digital Twins
Authors: Zhang Yingnan , Zhang Kelly , Prakosa Adityo , James Cynthia , Zimmerman Stefan L , Carrick Richard , Sung Eric , Gasperetti Alessio , Tichnell Crystal , Murray Brittney , Calkins Hugh , Trayanova Natalia
Published: October 2023

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic cardiac disease that leads to ventricular tachycardia (VT), a life-threatening heart rhythm disorder. Treating ARVC remains challenging due to the complex underlying arrhythmogenic mechanisms, which involve structural and electrophysiological (EP) remodeling. Here, we developed a novel genotype-specific heart digital twin (Geno-DT) approach to investigate the role of pathophysiological remodeling in sustaining VT reentrant circuits and to predict the VT circuits in ARVC patients of different genotypes. This approach integrates the patient’s disease-induced structural remodeling reconstructed from contrast-enhanced magnetic-resonance imaging and genotype-specific cellular EP properties. In our retrospective study of 16 ARVC patients with two genotypes: plakophilin-2 (
PKP2
,
n
= 8) and gene-elusive (GE,
n
= 8), we found that Geno-DT accurately and non-invasively predicted the VT circuit locations for both genotypes (with 100%, 94%, 96% sensitivity, specificity, and accuracy for GE patient group, and 86%, 90%, 89% sensitivity, specificity, and accuracy for
PKP2
patient group), when compared to VT circuit locations identified during clinical EP studies. Moreover, our results revealed that the underlying VT mechanisms differ among ARVC genotypes. We determined that in GE patients, fibrotic remodeling is the primary contributor to VT circuits, while in
PKP2
patients, slowed conduction velocity and altered restitution properties of cardiac tissue, in addition to the structural substrate, are directly responsible for the formation of VT circuits. Our novel Geno-DT approach has the potential to augment therapeutic precision in the clinical setting and lead to more personalized treatment strategies in ARVC.
Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition
Authors: Sarver Dylan C. , Garcia-Diaz Jean , Riddle Ryan C. , Wong G. William
Published: October 2023

Genome-wide association studies (GWAS) have identified a large number of candidate genes believed to affect longitudinal bone growth and bone mass. One of these candidate genes,
TMEM263
, encodes a poorly characterized plasma membrane protein. Single nucleotide polymorphisms in TMEM263 are associated with bone mineral density in humans and mutations are associated with dwarfism in chicken and severe skeletal dysplasia in at least one human fetus. Whether this genotype-phenotype relationship is causal, however, remains unclear. Here, we determine whether and how TMEM263 is required for postnatal growth. Deletion of the
Tmem263
gene in mice causes severe postnatal growth failure, proportional dwarfism, and impaired skeletal acquisition. Mice lacking Tmem263 show no differences in body weight within the first two weeks of postnatal life. However, by P21 there is a dramatic growth deficit due to a disrupted GH/IGF-1 axis, which is critical for longitudinal bone growth.
Tmem263
-null mice have low circulating IGF-1 levels and pronounced reductions in bone mass and growth plate length. The low serum IGF-1 in
Tmem263
-null mice is due to a deficit in hepatic GH receptor (GHR) expression and GH-induced JAK2/STAT5 signaling. Consequently, Tmem263 loss-of-function results in GH insensitivity (GHI), and a dramatic alteration in the GH-regulated transcriptome in liver. Our data validates the causal role for Tmem263 in regulating postnatal growth and raises the possibility that rare mutations or variants of
TMEM263
may potentially cause GHI and impair linear growth.
Effect of Financial Behavior, Childhood Consumer Experience, And Financial Wellness on Financial Well-Being
Authors: Herdjiono Irine , Siswantoyo Siswantoyo , Sukiyono Ketut , Hutama Ponty SP , Hakim Arif Rahman , Nggaruaka Tobias , Awotkay Apolinaris S. , Lola Murniati Arruan
Published: October 2023

Research question: This study aims to examine the effect of financial behavior, childhood consumer experience and financial wellness on financial well-being. Motivation: Good financial education will improve financial behavior and financial wellness. Data: The population of this research was students who are in Merauke, Papua, the border area of Indonesia. The sample was selected using a purposive sampling technique producing 386 respondents. Tools: Data analysis using was undertaken using a multiple regression analysis. Findings: The results showed that financial behavior had a particial, but significant effect on financial well-being, childhood consumer experience had no significant effect on financial well-being, and financial wellness had a significant effect on financial wellbeing. Simultaneously, financial behavior, childhood consumer experience and financial wellness had an effect on financial well-being. The limitation of the research comprised of individuals living in certain areas that are strongly influenced by certain socio-cultural conditions. Contribution: The implication of the results of this study is that it may be too early for children to receive education about finance. This research was conducted in Indonesia, in a border region, and as it is one of the countries with the largest population in Asia, the aspect of individual financial management is one of the problems hindering efforts to advance the economy.
Effect of the index of cardiac electrophysiological balance on major adverse cardiovascular events in patients with diabetes complicated with coronary heart disease
Authors: Lin Yuan , Zhou Fang , Wang Xihui , Guo Yaju , Chen Weiguo
Published: October 2023

Purpose

To investigate the prognostic value of the index of cardio-electrophysiological balance (ICEB) and its association with major adverse cardiac events (MACE) and cardiovascular death in diabetic patients complicated with coronary heart disease.

Methods

A total of 920 diabetic patients were enrolled in this longitudinal study. Participants were categorized into three groups based on their ICEB levels: normal ICEB, low ICEB, and high ICEB. The primary outcome was the occurrence of MACE, and secondary outcomes included cardiovascular death, coronary heart disease (CHD), heart failure (HF), and sudden cardiac arrest (SCA). Patients were followed for a median period of 3.26 years, and the associations between ICEB levels and various outcomes were evaluated.

Results

Over the follow-up period, 46 (5.0%) MACE were observed in the normal ICEB group, 57 (6.2%) in the low ICEB group, and 62 (6.8%) in the high ICEB group. Elevated ICEB levels were found to be associated with a higher risk of MACE and cardiovascular death. A significant relationship between ICEB levels and the risk of MACE was observed for both genders. The risk of MACE increased with each unit increment in the ICEB index. However, the two-stage linear regression model did not outperform the single-line linear regression models in determining the threshold effect.

Conclusion

This study demonstrates the potential utility of ICEB, derived from a standard non-invasive ECG, as a prognostic tool for predicting MACE and cardiovascular death in diabetic patients complicated with CVD. The associations between ICEB levels and the risk of MACE highlight the importance of understanding cardiac electrophysiological imbalances and their implications in CVD.
Analysis of factors influencing the pathological complete remission (ipCR) in patients with internal mammary lymph node metastasis after neoadjuvant chemotherapy
Authors: Li Yang , Fei Yang
Published: October 2023

Objective

To investigate the factors impacting pathological complete remission (ipCR) of the internal mammary lymph nodes in patients with internal mammary lymph node metastasis (IMLN) after adjuvant chemotherapy.

Methods

Sixty-five cases of primary breast cancer (BC) with IMLN metastasis who had received neoadjuvant chemotherapy (NAC) were retrospectively analyzed. Postoperative pathology was used to divide the patients into ipCR and non-ipCR groups. Univariate and multivariate analyses were performed on ipCR after NAC. A receiver operating characteristic (ROC) curve was used to evaluate the predictive value of the factors related to ipCR and a Kaplan-Meier curve was used to analyze prognosis.

Results

Twenty-nine (44.62%) of the 65 female patients received ipCR after NAC. Significant differences in hormone receptor (HR) negative and axillary pathological complete response (apCR) rates between the ipCR and non-ipCR group (P < 0.05). Multivariate logistic regression analysis showed that HR (OR = 2.698) and apCR (OR = 4.546) were the most significant factors that influenced ipCR (P < 0.05). The ROC curves showed that the area under the curves (AUC) for HR and apCR for the prediction of ipCR were 0.744 and 0.735 respectively. The AUC for the combined detection was 0.905. The average disease free survival (DFS) for patients in the ipCR group was 94.0 months which was significantly longer compared to patients in the non-ipCR group (64.2 months) (χ2 = 4.265, P = 0.039). No significant difference in OS was detected between the two groups (P > 0.05).

Conclusions

ipCR after NAC is correlated with HR and apCR. HR combined with apCR has value in predicting ipCR. ipCR has prognostic value in patients with IMLN metastasis and may have the potential to inform clinical decision-making. Further validation of these findings is required through larger-scale prospective studies.
KSFinder—a knowledge graph model for link prediction of novel phosphorylated substrates of kinases
Authors: Anandakrishnan Manju , Ross Karen E. , Chen Chuming , Shanker Vijay , Cowart Julie , Wu Cathy H.
Published: October 2023

Background

Aberrant protein kinase regulation leading to abnormal substrate phosphorylation is associated with several human diseases. Despite the promise of therapies targeting kinases, many human kinases remain understudied. Most existing computational tools predicting phosphorylation cover less than 50% of known human kinases. They utilize local feature selection based on protein sequences, motifs, domains, structures, and/or functions, and do not consider the heterogeneous relationships of the proteins. In this work, we present KSFinder, a tool that predicts kinase-substrate links by capturing the inherent association of proteins in a network comprising 85% of the known human kinases. We also postulate the potential role of two understudied kinases based on their substrate predictions from KSFinder.

Methods

KSFinder learns the semantic relationships in a phosphoproteome knowledge graph using a knowledge graph embedding algorithm and represents the nodes in low-dimensional vectors. A multilayer perceptron (MLP) classifier is trained to discern kinase-substrate links using the embedded vectors. KSFinder uses a strategic negative generation approach that eliminates biases in entity representation and combines data from experimentally validated non-interacting protein pairs, proteins from different subcellular locations, and random sampling. We assess KSFinder’s generalization capability on four different datasets and compare its performance with other state-of-the-art prediction models. We employ KSFinder to predict substrates of 68 “dark” kinases considered understudied by the Illuminating the Druggable Genome program and use our text-mining tool, RLIMS-P along with manual curation, to search for literature evidence for the predictions. In a case study, we performed functional enrichment analysis for two dark kinases - HIPK3 and CAMKK1 using their predicted substrates.

Results

KSFinder shows improved performance over other kinase-substrate prediction models and generalized prediction ability on different datasets. We identified literature evidence for 17 novel predictions involving an understudied kinase. All of these 17 predictions had a probability score ≥0.7 (nine at >0.9, six at 0.8–0.9, and two at 0.7–0.8). The evaluation of 93,593 negative predictions (probability ≤0.3) identified four false negatives. The top enriched biological processes of HIPK3 substrates relate to the regulation of extracellular matrix and epigenetic gene expression, while CAMKK1 substrates include lipid storage regulation and glucose homeostasis.

Conclusions

KSFinder outperforms the current kinase-substrate prediction tools with higher kinase coverage. The strategically developed negatives provide a superior generalization ability for KSFinder. We predicted substrates of 432 kinases, 68 of which are understudied, and hypothesized the potential functions of two dark kinases using their predicted substrates.
LA SATISFACCIÓN DE LAS PERSONAS Y LA COMPRENSIÓN DE LA SUSTENTABILIDAD EN LOS BARRIOS DEL GRAN SANTIAGO
Authors: Fuentes Luis , Greene Margarita , Rodríguez Sebastián , Señoret Andrés , Figueroa Cristhian
Published: October 2023

La discusión sobre desarrollo sustentable ha incorporado diferentes aproximaciones recientes como la vida cotidiana, la justicia social, participación política, economía saludable, la regeneración de la naturaleza y la satisfacción de las personas, como un elemento clave de bienestar y calidad de vida de las sociedades. En este contexto, y tomando en cuenta la satisfacción para comprender de manera integral cómo las ciudades pueden transitar hacia la sustentabilidad, es que, este documento, aborda la definición propuesta de sustentabilidad realizada por CEDEUS, una metodología para estudiarlo a través de diferentes tipologías de ciudad, y analizar cómo ha cambiado la satisfacción de las personas con su comunidad, entorno construido y situación laboral durante la pandemia por COVID-19 en el Gran Santiago.
La obsolescencia de la vivienda colectiva moderna como oportunidad de rehabilitación: estrategias de intervención para revertir la obsolescencia aplicadas en el caso de la torre UNCTAD III
Authors:   , Teillery Delattre Dominga
Published: October 2023

La vigencia de la arquitectura moderna en la actualidad se encuentra amenazada por dos principales razones. En primer lugar, es posible asociar ciertas obsolescencias específicas a este periodo, al presentar determinadas características que le otorgan una “caducidad” a estos edificios. Por otra parte, no hay un reconocimiento especial por el común de esta arquitectura, exceptuando las obras icónicas del movimiento, por lo que tanto su valor arquitectónico como estructural es menospreciado, significando su destrucción indiscriminada y exenta de remordimiento. Ambos factores actúan en conjunto hacia un declive desapercibido de esta arquitectura. Es utópico pensar que un edificio es eterno tal cual fue concebido, sin intervención o resguardo alguno. Así como existe un deterioro material directamente proporcional a los años de vejez, la valorización del inmueble ocurre en dirección contraria. Con el pasar del tiempo su trascendencia disminuye y se hace cada vez más difusa la razón por la cual no demoler. La obsolescencia juega un rol fundamental en este proceso, al minuto de presentarse incrementa exponencialmente la inviabilidad del edificio lo aleja cada vez más de su recuperación, acabando con un abandono o demolición de éste, siendo un destino que genera un impacto enorme en el medioambiente y significa una importante pérdida del patrimonio moderno no reconocido. En esta investigación se estudiarán las obsolescencias presentes en el modernismo, demostrado en los conjuntos habitacionales de la época en Chile, a modo de contextualizar la propuesta de “habitar” del movimiento moderno en oposición con la actual. Tras esta evidencia de evolución, es posible determinar estrategias de intervención para revertir dicho fenómeno y velar por la preservación de estructuras existentes desaprovechadas. Se plantea el no construir como una premisa sustentable llevada a cabo por el reuso adaptativo de los edificios, impulsado por el reconocimiento de un patrimonio moderno según su valor arquitectónico y oportunidad circular, a diferencia del valor patrimonial tradicional. Dicho estudio es puesto en práctica en un caso real, poniendo a prueba el alcance de rehabilitación de un edificio en obsolescencia. El ejemplo de la torre del edificio de la UNCTAD III se presenta como una oportunidad de reuso, donde se explora su capacidad por incorporar vivienda en un diseño originalmente para oficinas.
La huella del agua como identidad de paisaje. Develar y revalorizar: Quebrada Las Tinajas
Authors:   , Ahumada Atabales Bárbara Constanza
Published: October 2023

El paisaje de piedemonte de la ciudad de Santiago está caracterizado por la configuración de su superficie de alto relieve cordillerano y sus rasgos físicos reconocibles como conos aluviales, quebradas y laderas. Las quebradas aparecen como los espacios que existen entre laderas y cuya importancia está dada al estar destinadas al paso gradual de las aguas hacia la urbanización, preservando la humedad y albergando la mayor parte de la vegetación. Históricamente, fueron tierras fértiles y cultivables que permitían la infiltración y la recarga del acuífero, sosteniendo la vegetación del valle. Estos elementos naturales de piedemonte se han visto amenazados por el fenómeno de la expansión urbana en la ciudad de Santiago, el cual ha experimentado un considerable aumento en su tejido durante los últimos años, ha provocado que las edificaciones avancen hacia la montaña, generando un enfrentamiento entre usos de suelo urbano y suelo natural, irrumpiendo el territorio de las quebradas y, al mismo tiempo, alterando su cauce natural. Esta expansión de la ciudad sólo ha podido ser “frenada” por la fijación de un límite urbano ficticio en base a la altura de la cordillera. Dentro de un contexto de cambio climático donde se han experimentado fuertes aumentos de temperatura y escasas pero significativas lluvias, las aguas de quebradas han aumentado sus niveles de manera considerable, generando inundaciones y remoción de masas a lo largo del tiempo. Sin embargo, muchas de estas quebradas no son siempre permanentes, lo cual ha provocado que estos acontecimientos sean olvidados por la población, y en consecuencia, los bordes comienzan a ser edificados de manera ascendente, dejando atrás su grado de peligro, provocando una pérdida de identidad y, por consiguiente, una degradación del paisaje. Para esto se trabaja con un caso de estudio específico que posee la característica de enfrentarse a un punto de inflexión entre la cordillera y la urbanización ascendente, modificando su cauce de manera subterránea bajo la trama urbana, y que finaliza su recorrido en un canal de regadío de gran envergadura. Este encuentro de cauce de agua natural y artificial junto con el problema de la urbanización y privatización de ciertos sitios aledaños a la quebrada generan una oportunidad de proyecto de arquitectura del paisaje dando paso a la construcción de una identidad del agua de la quebrada.
Jornadas para empoderar estudiantes como líderes de la prevención de violencia escolar en colegios y liceos de la comuna de Melipilla
Authors:   , Cartes Cartes Bharti Joanna
Published: October 2023

En este informe se detalla un plan de acción de comunicación y educación diseñado para desarrollar liderazgo estudiantil en niños y adolescentes de colegios y liceos de la comuna de Melipilla, a partir de una experiencia educativa que tuvo lugar el año 2022 en dicha comuna. En primer lugar, se expone un diagnóstico general del plan de convivencia escolar comunal de la Municipalidad de Melipilla, para luego enfocarse en una de sus estrategias: “Jornadas de liderazgo estudiantil para la prevención de violencia escolar”. A partir de este diagnóstico se propone un plan de acción piloto para realizar mejoras a las jornadas en aspectos metodológicos, integrando el uso de tecnologías para el aprendizaje y con foco en un liderazgo estudiantil colaborativo, desde una mirada de educomunicación.
Propuesta de un manual psicoeducativo para personas con sospecha o diagnóstico de trastorno de personalidad límite
Authors:   , Bozzolo Richter Sofía Andrea
Published: October 2023

El trastorno límite de personalidad (TLP) se manifiesta como un patrón perdurable e inflexible de inestabilidad e hipersensibilidad interpersonal, labilidad afectiva, impulsividad y una identidad poco desarrollada o inestable (APA, 2013). También se asocia a un deterioro del funcionamiento psicosocial y de la calidad de vida, además de una menor expectativa de vida, y múltiples enfermedades físicas y trastornos psicológicos comórbidos (APA, 2013). Una vez que se realiza el diagnóstico, la evidencia apoya la comunicación inmediata al paciente, acompañada de psicoeducación (Gunderson, 2018b). Esta tiene como objetivo proporcionar al paciente y su familia información sobre las diversas facetas de la enfermedad y su tratamiento, para que puedan trabajar junto con los profesionales de la salud mental para lograr un mejor resultado general (Sarkhel et al., 2020). Sin embargo, aún hay profesionales de la salud reticentes a comunicar el diagnóstico, y la evidencia indica que los pacientes muchas veces tienen experiencias de diagnóstico negativas o que no satisfacen sus necesidades psicoeducativas (Lester et al., 2020; Stalker et al., 2005; Veysey, 2014 ; Bonnington & Rose, 2014; Ramón et al., 2001). Una posible solución para esta problemática es la creación de material psicoeducativo que pueda difundirse de forma gratuita a través del internet. La revisión bibliográfica indica una ausencia de material psicoeducativo gratuito y actualizado en español, por lo que el objetivo del presente proyecto fue desarrollar un manual psicoeducativo para personas diagnosticadas o con sospecha de TLP. Este se desarrolló mediante la recopilación y revisión de literatura académica, guías y manuales psicoeducativos disponibles dirigidos a personas diagnosticadas con un TLP, e incorpora el feedback de psicólogos con experiencia en el diagnóstico, así como de personas diagnosticadas con el trastorno, cuyos contactos fueron facilitados por la Fundación TLP Chile y el Instituto Chileno de Trastornos de Personalidad. El material desarrollado será divulgado a través de la plataforma web Psiconecta y las instituciones que cooperaron con el desarrollo del producto.
An investigation of the problems encountered by the teachers in secondary education in the trnc in the classroom management, according to the opinions of school administrators
Authors: Dericioğlu Sonay , Sapmaz Simge , Öznacar Behcet
Published: October 2023

The main aim of this research is to determine the understanding of school administrators regarding classroom management and their attitudes towards encountered-difficulties, as well as to provide coping strategies to teachers facing these problems. The study group of the current research consisted of a total of 20 school administrators, including 5 principals and 15 vice-principals, working in secondary education institutions during the spring semester of the 2022-2023 academic year, affiliated with the Ministry of Education, Youth and Sports of Northern Cyprus. A qualitative research model was applied in the study, specifically using the snowball model from qualitative research models. A semi-structured interview form was used as the data collection tool. The obtained data were categorized into themes and interpreted. According to the data, school administration eased their views on the disruptions in classroom management caused by overcrowded cl ass rooms, a high number of foreign students, lack of parental involvement, the presence of students causing discipline problems,as well as the students' lack of knowledge of rules and responsibility, which became more evident with the onset of the pandemic. School administrators stated that the problems encountered were related to inadequate in infrastructure and students' lack of respect towards teachers. They suggested that teachers should participate in in-service training programs to enhance their classroom management skills and emphasized the need for the establishment of new secondary education institutions.
Is Centric Relation and Centric Occlusion Discrepancy an Enigma? An Orthodontic Perspective
Authors: Muthuraman Naveen Raj , Gnaneswar Sangeetha Morekonda , Jasper Advina Mary , Bahudeen Mohammed Sohail
Published: October 2023

Centric Relation (CR) and Centric Occlusion (CO) are commonly used references in clinical dentistry. CR represents bone-tobone contact independent of teeth contact, while CO refers to occlusal contact between the maxillary and mandibular teeth. The coincidence or discrepancy between CR and CO has been the subject of many challenging debates. These reference positions of the mandible typically do not align in natural dentition. When a discrepancy exists, the mandible slides from CR to CO to stabilise the occlusion. Such functional interferences can result in occlusal wear, excessive tooth mobility, poor periodontal health, temporomandibular joint dysfunction, and myofascial pain. Orthodontists who follow gnathologic occlusion recommend using study models mounted on articulators in the CR position to coincide with the treatment of CR-ICP (Maximal Intercuspal Position - ICP). Generally, a discrepancy of 1.5 mm in the vertical and horizontal planes and 0.5 mm in the transverse plane is considered acceptable as it does not cause significant pathology. In the present article authors, we discuss the discrepancy between CR and CO, the dentofacial characteristics of patients with CR-CO discrepancy, its relationship with TMJ dysfunction, and its impact on cephalometric analysis and deprogramming. A clear understanding of CO and CR allows clinicians to approach treatment planning in an organised manner.