Microsatellite instability in young patients with rectal cancer: molecular findings and treatment response
Authors:   REACCT Collaborative, Zaborowski Alexandra M , Abdile Ahmed , Adamina Michel , Aigner Felix , d'Allens Laura , Allmer Caterina , Álvarez Andrea , Anula Rocio , Andric Mihailo , Atallah Sam , Bach Simon , Bala Miklosh , Barussaud Marie , Bausys Augustinas , Beggs Andrew , Bellolio Felipe , Bennett Melissa-Rose , Berdinskikh Anton , Bevan Vicki , Biondo Sebastiano , Bislenghi Gabriele , Bludau Marc , Brouwer Nelleke , Brown Carl , Bruns Christiane , Buchanan Daniel D , Buchwald Pamela , Burger Jacobus W A , Burlov Nikita , Campanelli Michela , Capdepont Maylis , Carvello Michele , Chew Hwee-Hoon , Christoforidis Dimitri , Clark David , Climent Marta , Collinson Rowan , Cologne Kyle G , Contreras Tomas , Croner Roland , Daniels Ian R , Dapri Giovanni , Davies Justin , Delrio Paolo , Denost Quentin , Deutsch Michael , Dias Andre , D'Hoore André , Drozdov Evgeniy , Duek Daniel , Dunlop Malcolm , Dziki Adam , Edmundson Aleksandra , Efetov Sergey , El-Hussuna Alaa , Elliot Brodie , Emile Sameh , Espin Eloy , Evans Martyn , Faes Seraina , Faiz Omar , Figueiredo Nuno , Fleming Fergal , Foppa Caterina , Fowler George , Frasson Matteo , Forgan Tim , Frizelle Frank , Gadaev Shamil , Gellona Jose , Glyn Tamara , Goran Barisic , Greenwood Emma , Guren Marianne G , Guillon Stephanie , Gutlic Ida , Hahnloser Dieter , Hampel Heather , Hanly Ann , Hasegawa Hirotoshi , Iversen Lene Hjerrild , Hill Andrew , Hill James , Hoch Jiri , Hompes Roel , Hurtado Luis , Iaquinandi Fabiano , Imbrasaite Ugne , Islam Rumana , Jafari Mehrenah D , Salido Andrea Jiménez , Jiménez Toscano Marta , Kanemitsu Yukihide , Karachun Aleksei , Karimuddin Ahmer A , Keller Deborah S , Kelly Justin , Kennelly Rory , Khrykov Gleb , Kocian Peter , Koh Cherry , Kok Neils , Knight Katrina A , Knol Joep , Kontovounisios Christos , Korner Hartwig , Krivokapic Zoran , Kronberger Irmgard , Kroon Hidde Maarten , Kryzauskas Marius , Kural Said , Kusters Miranda , Lakkis Zaher , Lankov Timur , Larson David , Lázár György , Lee Kai-Yin , Lee Suk Hwan , Lefèvre Jérémie H , Lepisto Anna , Lieu Christopher , Loi Lynette , Lynch Craig , Maillou-Martinaud Helene , Maroli Annalisa , Martin Sean , Martling Anna , Matzel Klaus E , Mayol Julio , McDermott Frank , Meurette Guillaume , Millan Monica , Mitteregger Martin , Moiseenko Andrei , Monson John R T , Morarasu Stefan , Moritani Konosuke , Möslein Gabriela , Munini Martino , Nahas Caio , Nahas Sergio , Negoi Ionut , Novikova Anastasia , Ocares Misael , Okabayashi Koji , Olkina Alexandra , Oñate-Ocaña Luis , Otero Jaime , Ozen Cihan , Pace Ugo , Julião Guilherme Pagin São , Panaiotti Lidiia , Panis Yves , Papamichael Demetris , Patel Swati , Uriburu Juan Carlos Patrón , Peng Sze-Lin , Pera Miguel , Perez Rodrigo O , Petrov Alexei , Pfeffer Frank , Phang Terry P , Poskus Tomas , Pringle Heather , Proud David , Raguz Ivana , Rama Nuno , Rasheed Shahnawaz , Raval Manoj J , Rega Daniela , Reissfelder Christoph , Meneses Juan Carlos Reyes , Ris Frederic , Riss Stefan , Rodriguez-Zentner Homero , Roxburgh Campbell S , Saklani Avanish , Sammour Tarik , Saraste Deborah , Schneider Martin , Seishima Ryo , Sekulic Aleksander , Seppala Toni , Sheahan Kieran , Shlomina Alexandra , Sigismondo Guiseppe , Singnomklao Tongplaew , Siragusa Leandro , Smart Neil , Solis-Peña Alejandro , Spinelli Antonino , Staiger Roxane D , Stamos Michael J , Steele Scott , Tan Ker-Kan , Tanis Pieter J , Tekkis Paris , Teklay Biniam , Tengku Sabrina , Tsarkov Petr , Turina Matthias , Ulrich Alexis , Vailati Bruna B , van Harten Meike , Verhoef Cornelis , Warrier Satish , Wexner Steven , de Wilt Hans , Weinberg Benjamin A , Wells Cameron , Wolthuis Albert , Xynos Evangelos , You Nancy , Zakharenko Alexander , Zeballos Justino , Zhou Jonathan , Winter Des C 
Published: November 2021

In this study of 400 patients with early-onset rectal cancer, 12.5 per cent demonstrated microsatellite instability (MSI). MSI was associated with a reduced likelihood of nodal positivity, an increased rate of pathological complete response, and improved disease-specific survival.