bluuebunny/crossref_metadata_2025 huggingface dataset:
Repensando a ordem de prioridade dos direitos educacionais na concepção de justiça educacional democrática global de Julian Culp
Authors: Petry Franciele
Published: February 2025

Resumo O presente trabalho tem como objetivo analisar criticamente a contribuição oferecida pela concepção de justiça educacional democrática global defendida por Julian Culp. Tal abordagem se insere no debate contemporâneo sobre justiça educacional oferecendo uma posição intermediária entre duas vertentes teóricas importantes, ou seja, entre posições que enfatizam a distribuição da educação em contraposição às que defendem a educação democraticamente adequada. Para Culp, a busca pela justiça educacional teria que garantir, prioritariamente, a oferta de uma educação democrática onde isso for necessário para garantir uma ordem democrática e deixar a definição relativa à distribuição da educação para procedimentos democráticos de tomada de decisão. Além disso, o autor defende a prioridade da realização da educação democrática global em todos os países para que, depois, se assegure a igualdade de oportunidades educacionais na dimensão doméstica. Este artigo pretende questionar a ordem de prioridades conferida por Culp aos direitos educacionais abrangidos por sua concepção de justiça educacional democrática global em sociedades onde é necessário alcançar uma ordem democrática mais estável. Por meio da discussão de alguns elementos que podem ser encontrados em sociedades com grandes desigualdades sociais e com traços autoritários, sugere-se que tal ordem seja invertida ou que a promoção de educação democraticamente adequada possa ser considerada moralmente equivalente à igualdade de oportunidades.
Three new and some rare weevils in Hungary (Coleoptera: Curculionidae)
Authors: Szénási Valentin
Published: February 2025

Three weevil species (Coleoptera: Curculionidae), namely Brachysomus verae Košťál,
1992, Otiorhynchus aurifer Boheman, 1842, and Otiorhynchus turca Boheman, 1842, are reported
from Hungary for the first time. According to recent taxonomic changes, Otiorhynchus rotundus
Marseul, 1872 is deleted from the Hungarian checklist as its data pertain to Otiorhynchus
smreczynskii Cmoluch, 1968. Recent records of Ceutorhynchus subpilosus C. N. F. Brisout de
Barneville, 1881, Curculio gyongyiae Szénási, 2022, Mogulones albolineatus (J. Frivaldszky, 1878),
Otiorhynchus juglandis Apfelbeck, 1895, and Otiorhynchus ovalipennis Boheman, 1842 are also
presented.
Who does this benefit? A consideration of demographics in the access and impact of retirement from college sport programming
Authors: Kloetzer Hannah , Harry Molly , Taylor Elizabeth
Published: February 2025

Sport retirement can reveal a host of difficulties for college athletes including minimal career preparation, mental health struggles, and identity foreclosure. While college athletes almost always note the challenges of leaving their sport behind, these challenges can be mitigated through transition programming. However, what types of programming are more useful, and for whom, is understudied. Through a mixed method survey, this study explored differences in access and impact of retirement from sport programming based on athletes’ (n = 707) demographic differences (e.g., race, division), through the lens of Goodman and colleagues’ (2006) three phases of transition. Findings revealed that Black athletes and those from working class backgrounds found programs to be more impactful than other demographic groups, supporting the argument for personalized retirement support. Additionally, Division II athletes not only had the greatest access to retirement programming, but also found programming to have more impact than other divisions. However, athletes noted that more programs are needed for every division.
Data Analysis waveRAPID using Creoptix WAVEsystem v1
Authors: Capkin Eda
Published: February 2025

This protocol outlines the data analysis workflow for the Creoptix WAVEsystem using Repeated Analyte Pulses of Increasing Duration (RAPID) method. It covers essential steps including blank and DMSO corrections, and kinetic analysis using a 1:1 binding model. The procedure ensures accurate evaluation of biomolecular interactions through systematic assessment of sensorgram data and verification of kinetic parameters.
Larval Feeding v1
Authors: Stenhouse Steven , Morreale Rachel , Bajonero Johanna
Published: February 2025

Larval feeding protocol developed by the Applied Science and Technologies department of Lee County Mosquito Control District for the purpose of mass rearing Aedes aegypti larvae for the sterile insect technique program.
Weibull Reliability Methodology based on Cumulated Vibration Damage
Authors: Hernández Ramos María Magdalena , Piña Monarrez Manuel Román , Barraza Contreras Jesús Manuel , Monclova Quintanaz Osvaldo
Published: February 2025

In the paper, the formulated Weibull vibration reliability methodology is based on the cumulative vibration damage analysis. It lets us determine the reliability index of each damage element, each damage block, and the reliability of the analyzed element. The vibration cumulated damage is cumulated until D=1, by using the addressed vibration stress and a nonlinear cumulative damage model. Based on static and modal analysis, the vibration stress is determined by incorporating to it the geometry, weight and resonance effects. In the reliability analysis the Weibull shape (β) parameter is determined directly from the number of blocks, for which D=1. The damage element, damage block, and element reliability are all determined based on the values of beta (β) and D_i elements. Finally, based on the cumulated applied cycles n_i the Weibull scale (η) parameter is determined by to each D_i elements, damage block, and analyzed element.
Molecular Dynamics of Twisted β-Sheet inside a Protein Dimer of TTHA1013 Thermus thermophilus
Authors: Chirgadze Y.N. , Likhachev I.V. , Balabaev N.K. , Brazhnikov E.V.
Published: February 2025

α-Helix and β-sheet are two basic secondary structure motifs of protein molecules. A true native protein state is realized in a water solution. Under these conditions the proteins carry out the dynamic properties and, what is important, fulfill their various functions. We recently studied molecular dynamics of α-helical fragment of the T. thermophilus TTHA1013 protein in a water solution. Here we consider dynamics of β-sheet in the dimer of this protein. Dynamics of only main chain Cα-atoms were studied. One of the most distinctive type of fluctuations was detected along four independent dynamic trajectories with a total time of 200 nanoseconds. This fluctuation, called a “butterfly wing”, corresponds to the movements of Cα-atoms of the peripheral residues of the β-sheet fragment. While Cα-atoms of the central part of the sheet remain immobile because of hydrophobic interaction of the side chains within the molecular core.
Modelos de Masculinidad en Libros Infantiles y Recursos Electrónicos de Prehistoria
Authors: San-Martín Alberto , Santisteban-Fernández Antoni
Published: February 2025

Los libros infantiles de prehistoria (LIP) y los recursos electrónicos de prehistoria (REP) son recursos educativos frecuentemente utilizados en el aula. Si bien se han estudiado los estereotipos de género y la presencia/ausencia de personajes masculinos y femeninos en estos formatos, no existen aún estudios específicos que aborden la representación de la masculinidad en dichos dispositivos. El objetivo central de este estudio es analizar los modelos de masculinidad en las representaciones iconográficas de una muestra de LIP (n=5) y de REP (n=2).  Para ello, se construye un instrumento categorial, con vocación de replicabilidad, con datos a priori a partir de la revisión exhaustiva y sistemática de bibliografía y datos emergentes de la muestra. Desde un enfoque socio-crítico con perspectiva feminista y los principios de la literacidad visual crítica se sigue un método mixto. Por un lado, cualitativo descriptivo y por otro cuantitativo estadístico descriptivo. Los resultados obtenidos informan de la presencia extendida del modelo de masculinidad hegemónica, dificultando la transposición didáctica de los avances recientes en prehistoria y arqueología relativos a la colaboración necesaria entre sexos como parte de un mismo colectivo y donde las tareas de mantenimiento y de cuidados fueron esenciales para la vida y la supervivencia.
Ray Bradbury’s Stylistic Identity: The USE of Literary Devices
Authors:   Lviv National Environmental University, Dubnevych Nataliya Yu.
Published: February 2025

The article examines Ray Bradbury’s unique literary voice through his novel Dandelion Wine and focuses on analysing the recreation of expressive syntax in the translation done by V. Mytrofanov. The theoretical basis from Ukrainian and foreign scholars in translation studies, stylistics, and linguistics served as a framework for employing contrastive analysis, statistical evaluation, and descriptive methods to assess the adequacy of translation in preserving Ray Bradbury’s hypersyntax. The article reveals the results of the research involving 585 examples of syntactical stylistic devices, investigates their functioning and the regularities and peculiarities of their recreation, and presents a statistical analysis based on device classification. The paper’s novelty lies in identifying stylistic peculiarities of R. Bradbury’s literary expressiveness, tracing relevant components of the text, and recreating them, which is crucially important for adequate translation. The research findings contribute to translation studies, contrastive syntax, and stylistics, offering insights for further research into stylistic devices at the level of sentence, paragraph, or stylistic whole, as well as a basis for looking at expressiveness as a systemic phenomenon. This research highlights the intricacies of Bradbury’s prose and sheds light on translation strategies for tackling stylistic nuances, ultimately enriching the discourse on literary translation and stylistic analysis.
The joint use of ABC/VEN analysis and the Beers criteria for optimizing expenditure of funds and rational prescribing of medications to elderly patients
Authors: Makhmudova O. A. , Avkhadieva G. F. , Bagdanova O. G. , Khaziakhmetova V. N.
Published: February 2025

Objective: to conduct a pharmacoeconomic evaluation of the rationality of prescribing medications and to analyze the frequency of prescribing potentially inappropriate medications to patients over 65 years old using the example of additional preferential drug provision.

Material and methods. The analysis was based on registers of medications dispensed within the framework of additional drug provision over 2019–2021 period. We conducted an integrated study combining ABC/VEN analysis and the Beers criteria to assess the rationality of pharmacotherapy.

Results. The analysis of the cost structure for medicines showed a positive trend in the distribution of categories V, E, N (vital, essential, nonessential) in A, B, C groups. In 2019, 13.7% of the budget was spent on the procurements of drugs of N category; in 2020, this indicator was 10.6%; and in 2021, the costs for the procurements of drugs of N category decreased to 2.6%. Expenditures for drugs in V and E categories increased from 86.3% to 97.4%. The prevalence of polypragmasy (prescription frequency of 5 or more drugs with different international nonproprietary names per patient for month) among patients over 65 years old reached 11% in 2019, 13% in 2020, and 1% in 2021. According to the Beers criteria, patients over 65 years old were prescribed potentially inappropriate drugs according to the Beers criteria in 12.03% of cases in 2019, in 10.84% of cases in 2020, and in 9.7% of cases in 2021.

Conclusion. Due to comprehensive ABC/VEN analysis and the Beers criteria tool it was possible to evaluate the rationality of expenditures on additional drug provision over the period from 2019 to 2021, as well as the rationality of prescribing medications to patients over 65 years old. The use of Beers criteria enables to optimize pharmacotherapy in elderly patients.
Dynamics of anticancer drug use in Russian hospitals: a five-year retrospective analysis
Authors: Agafonova J. A. , Omelyanovskiy V. V.
Published: February 2025

Background. Pharmaceutical provision for oncology patients involves complex and controversial issues, particularly the use of oral anticancer drugs (ACDs) in day hospitals. These facilities often distribute oral medications for outpatient use, leading to frequent legal disputes with territorial Compulsory Health Insurance funds. To determine whether this practice changes over time, it is necessary to analyze trends in the use of ACDs.

Objective: to identify trends in the use of different forms of ACDs in both inpatient and day hospital settings over a 5-year period.

Material and methods. The study analyzed medical care provided in inpatient and day hospital settings using depersonalized hospitalization records from oncology-focused medical organizations. The data from 2019 to 2023 were categorized into three groups: regimens with only oral administration, including combinations of multiple oral drugs; regimens with only injectable forms, including intravenous and subcutaneous administration; and combined regimens, including oral and other forms of administration. The annual distribution and trends in the use of different forms of ACDs were analyzed for both inpatient and day hospital settings over the 5-year period. A time series analysis was carried out to assess the dynamics, including the calculation of absolute and relative growth (or decline) rates. Time series smoothing was performed using aggregation and moving average methods.

Results. From 2019 to 2023, day hospitals in Russia exhibited an increase in the use of all ACD forms. The highest growth rate (79.9%) was observed for the use of oral therapy in 2020, with an overall increase from 9.25% to 29.09% over the study period. The combined regimens used in day hospitals demonstrated an increase in the proportion of oral therapy from 10.54% to 29.46%. However, inpatient settings exhibited a rise in the use of only injectable regimens from 17.65% to 23.32%. Conversely, the role of inpatient oral therapy significantly declined, with the proportion of oral-only and combined regimens decreasing from 43.59% to 1.18% and 30.47% to 12.95%, respectively.

Conclusion. The results provide an evaluation of the trends in ACDs use in Russian hospitals. Despite an overall increase in the use of all ACD forms in day hospitals, oral medications exhibited the highest growth rate.
Reorganization of public procurement of biosimilars and its economic effect on the monoclonal antibody market in Russia
Authors: Efremov A. Yu. , Vlasov A. M. , Gegechkori V. I. , Gorpinchenko N. V. , Ramenskaya G. V. , Litvinova T. M.
Published: February 2025

Background. The increasing number of registered biosimilarsof monoclonal antibodies (mAbs) is altering the structure of the pharmaceutical market by amplifying the share of domestic manufacturers. Therefore, investigating their economic effect appears highly relevant.

Objective: To examine the impact of biosimilars on the market for public procurement of medicinal products based mAbs during the period 2022–2023.

Material and methods. A list of registered drugs based on mAbs was compiled from the State Register of Medicines and the Unified Information System for Procurement databases. The study involved statistical and marketing methods, including normalization of drug costs to weighted average prices (rub/mg), ABC analysis to identify key positions based on expenditure, and competitive analysis to categorize drugs as either original or biosimilars.

Results. The analysis of weighted average prices for original drugs and biosimilars, as well as their procurement volumes, demonstrated a significant economic effect on the health care system. The greatest savings were achieved through the procurement of bevacizumab and pembrolizumab biosimilars, resulting in savings of 15.1 and 3.8 billion rubles, respectively. In the group of rituximab drugs, procurement of biosimilars led to savings of approximately 2 billion rubles.

Conclusion. The introduction of biosimilars into the public procurement market has significantly optimized costs, thereby increasing patient access to life-saving medicines. The results emphasize the necessity for further development of biosimilars market to enhance the efficiency of public procurement and improve drug accessibility. However, a comprehensive understanding of their economic advantages require clinical studies that confirm the efficacy and safety of biosimilars in real-world clinical practice.
Развитие подходов в решении задач спортивной науки
Authors: Шестаков Михаил Петрович
Published: February 2025

Цель статьи заключается в рассмотрении новых подходов в изучении проблемы моделирования сознательного управления спортивными движениями в соответствии с новыми научными данными с точки зрения философии спорта. В статье рассматриваются проблемы исследований в современном спорте, включая междисциплинарный подход к вопросам управления движениями и обучения им с использованием прогностического кодирования и построения генеративных моделей. Механизм вероятностного прогнозирования позволяет осуществить формализацию работы мозга при активном действии. Это позволяет создать теоретическую основу новой парадигмы в спорте — создание условий для использования организмом его естественных возможностей, близких к индивидуально максимальным. Определяется требование по построению логически обоснованной системы гипотез о взаимодействиях составляющих системы управления движениями и случаях их несовместимости, а также о факторах благоприятствующих и препятствующих гармоничному развитию двигательных функций, обеспечивающих их развертывание и полезную работу систем организма на разных этапах онтогенеза человека.
Percepção Ambiental de Alunos do Sexto ao Nono Ano do Ensino Fundamental de uma Escola Municipal Rural de Campo Grande (MS), Sobre a Avifauna Regional
Authors: Morais Rosiane de , Guedes Neiva Maria Robaldo , Andrade Luciana Paes de , Prado Melissa Pires do
Published: February 2025

Esse artigo apresenta os resultados de uma pesquisa exploratória realizada com alunos dos anos finais do ensino fundamental de uma escola pública rural, que buscou analisar a percepção ambiental sobre a avifauna local. O aporte teórico metodológico baseou-se na perspectiva transformadora descrita por Carlos Frederico Loureiro. Por meio de um questionário aplicado a todos os alunos matriculados do 6° ao 9° ano do Ensino Fundamental no ano de 2019, somando 159 questionários. Como resultados, se percebeu que os componentes curriculares citados pelos alunos que já abordaram a temática avifauna, restringiam-se às áreas de ciências naturais. Os alunos conheciam um grande número de aves, principalmente, às que pertenciam ao bioma do Cerrado, local onde a escola está inserida, e reconheciam a necessidade da conservação de áreas naturais para a manutenção das aves, e a sua importância ecológica. Coloração e vocalização foram as caraterísticas que mais atraiam os educandos. Diante dos resultados, avifauna é um tema gerador de diversas áreas do conhecimento, como estratégia didática para Educação Ambiental (EA). Sendo assim, surge à necessidade do debate diário de temas como sustentabilidade, biodiversidade local e EA, no ambiente escolar.
Palavras-chave: Ensino, Educação Ambiental, Aves, Recursos Naturais e Ecologia.
AbstractThis article presents the results of an exploratory research carried out with students in the final years of elementary school at a rural public school, which sought to analyze the environmental perception of local birdlife. The theoretical and methodological contribution was based on the transformative perspective described by Carlos Frederico Loureiro. Through a questionnaire applied to all students enrolled in the 6th to 9th year of Elementary School in 2019, totaling 159 questionnaires. As a result, it was noticed that the curricular components mentioned by students who had already covered the birdlife theme were restricted to the areas of natural sciences. The students knew a large number of birds, mainly those that belonged to the Cerrado biome, where the school is located, and recognized the need to conserve natural areas for the maintenance of birds, and their ecological importance. Coloring and vocalization were the characteristics that most attracted students. Given the results, birdlife is a topic that generates several areas of knowledge, as a teaching strategy for Environmental Education (EE). Therefore, there is a need for daily debate on topics such as sustainability, local biodiversity and EA, in the school environment.
Keywords: Teaching, Environmental Education, Birds, Natural Resources and Ecology.
A study on ocular and systemic manifestations of retinitis pigmentosa
Authors: Hariharan Rakshanda , Madduru Satyanarayana Reddy , Bommana Ugandhar Reddy
Published: February 2025

To study the pattern of ocular and systemic manifestations associated with retinitis pigmentosa and syndromic correlation and preventive strategies for the same.

: A prospective study on patients visiting blindness camp at our hospital, done over a period of 1 year. Each patient, age, sex, complaints, visual acuity, anterior segment findings and dilated fundus examination, B scan and Visual field analysis were done.

: A total of 50 eyes in 25 patients were investigated, of which 56% females and 44% males, 40% had a history of consanguinous marriage, positive family history of retinitis pigmentosa was noted in 20%. Night blindness (58.2%) and blurred vision (27.1%) were the main visual complaints. The BCVA showed that 03 patients had complete loss of vision, and 22 patients had low vision, among ocular findings most common was maculopathy (26.3%) followed by vitreous degenerations, other findings like nystagmus, microcornea, optic atrophy and posterior subcapsular cataract (most common anterior segment finding) were also present, and 4 patients had associated mental retardation, polydactyly and hypogonadism suggestive of Bardet Biedl syndrome.

Thus from our study we bring to light the common ocular and syndromic associations of retinitis pigmentosa to provide awareness about the disease and genetic counselling and its benefits to the patient and their families and the use of low vision aids to improving the quality of life. There is no known prescription practice cure for the disease at present, we can help in rehablitation of such patients and prevent the disease by proper genetic counselling.
Clinicoepidemiological study of penetrating ocular injuries and factors affecting visual outcome
Authors: Kushwaha Nitin , Som Vivek , Dubey Aditi , Maravi Pooja , Sharma Pankaj Kumar
Published: February 2025

Blindness among young adults due to ocular trauma has a huge socioeconomic cost and impact on the lives of such patients and their families. Thus, we evaluate the epidemiology and etiological factors and the factors affecting the outcome in penetrating eye injuries.

This one-year descriptive observational study was conducted at the Department of Ophthalmology, Gandhi Medical College, Bhopal, involving 50 patients. The Ocular Trauma Score (OTS) was used to estimate final visual acuity. The epidemiological, etiological factors and risk factors were analyzed using the chi-square test with a significance level of 5%.

Among the 50 patients, Majority of participants were found to be males (78%). 50% participants were less than 30 years of age, Majority (26%) of participants belonged to the age-group of 10-19 years. Among the participants, we found age and zone of injury are the factors which were significantly associated with the visual outcome of the patients whereas gender, mechanism of injury of the ocular trauma and the time elapsed between injury and primary repair were the factors which were significantly associated with the final structural outcome.

A nationwide online database for ocular injuries should be established. Legislation should be implemented to hold employers accountable for providing protective equipment to their employees. The NPCB should incorporate provisions for the physical, mental, social, and vocational rehabilitation of patients affected by ocular trauma.
Prevalence of dry eye disease among medical students in a tertiary care center: A cross sectional study
Authors: Pradeep Pakalapati , Radhika Kasilanka
Published: February 2025

Dry eye disease is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface, it is accompanied by increased osmolarity of the tear film and inflammation of the ocular surface. Aim is to estimate the prevalence of Dry eye disease (DED) among medical students.

In this prospective, cross-sectional study, after getting informed consent 100 medical students were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, average daily screen time and routine ophthalmological examination, Schirmer's test, and tear film break-up time (TBUT) as a screening method for identifying DED. The Data thus collected is entered in Microsoft excel sheet & analyzed using SPSS 20.0 version. Descriptive statistics were applied to summarize the demographic data, comparisons between categorical variables analyzed using Fisher's exact test.

The prevalence of DED among study participants was 43%, with 30% of students having mild DED. There is a significant association between screen time and DED (p<0.05).

The prevalence of DED among medical students is rising as a result of an increase in screen usage.
Comparative assessment of angiogenic and cytokine profiles in vitreous samples from patients with diabetic retinopathy and controls
Authors: Misra Smriti , Gangwar Saurabh , Agarwal Gargi , Mehfooz Samreen
Published: February 2025

To evaluate and compare the levels of key cytokines and angiogenic factors in the vitreous fluid of patients with clinically confirmed and staged diabetic retinopathy (DR) to those of non-DR controls, with the aim of identifying potential targets for novel therapeutic interventions.

Vitreous specimens were collected during 23-gauge vitrectomy from patients diagnosed with diabetic retinopathy (n = 17, at advanced stages requiring surgical intervention) and from control patients (n = 17) undergoing surgery for retinal holes or epiretinal membranes. The samples were analyzed for cytokines (IL-2, IL-4, IL-13, IL-1β, IL-6, and IFN-γ) using ELISA. Angiogenic factors, including placental growth factor (PGF), vascular endothelial growth factor (VEGF), and VEGF-A, were also measured. Statistical comparisons between the DR and control groups were performed.

In the DR group, pro-inflammatory cytokines IL-1β (p = 0.04) and IFN-γ (p = 0.06) showed elevated levels compared to controls, indicating an ongoing inflammatory response. No statistically significant differences were observed in IL-6 levels (p = 0.59). The immunomodulatory cytokine IL-13 appeared decreased in the DR group (p = 0.48), although this change was not statistically significant. Similarly, IL-2 (p = 0.74) and IL-4 (p = 0.80) levels did not differ significantly between groups. Angiogenic factors, including PGF, VEGF, and VEGF-A—already well known to be increased in DR—were found to be significantly elevated in DR patients (p < 0.05, p = 0.004), reinforcing their role in the pathophysiology of the disease.

These findings highlight an interplay between elevated angiogenic factors and a persistent pro-inflammatory cytokine milieu within the vitreous of patients with advanced DR. While endogenous immunomodulatory mechanisms such as IL-13 are present, they appear insufficient to counteract the active inflammatory and angiogenic processes. Augmenting anti-inflammatory responses or targeting angiogenic mediators may represent a viable therapeutic strategy to improve treatment outcomes in diabetic retinopathy.
Sepsis grave secundaria a Staphylococcus aureus productor de leucocidina de Panton-Valentine: a propósito de un caso
Authors: Muñoz Cutillas Agustín , Bellón Alonso Sara , Oujo Álamo Eduardo , Rodríguez-Tubío Dapena Santiago , Merino Hernández Amaia , Rodríguez Cimadevilla Juan Luis
Published: February 2025

INTRODUCCIÓN: Staphylococcus aureus es una bacteria capaz de causar gran variedad de infecciones con un extenso rango de gravedad. La leucocidina de Panton-Valentine (PVL) es una exotoxina con efectos proinflamatorios y citotóxicos, cuya presencia se relaciona con mayor gravedad, especialmente en casos de neumonía necrotizante.
PRESENTACIÓN DEL CASO: Lactante de 5 meses con fiebre y decaimiento de 24 horas de evolución. En Urgencias presentó cuadro compatible con choque séptico, precisando expansiones repetidas de volumen, inotrópicos, antibioterapia y ventilación mecánica. En la exploración física se observó celulitis en la pierna derecha, precisando fasciotomía por síndrome compartimental. Los análisis mostraron leucopenia e importante elevación de reactantes de fase aguda. Durante el ingreso desarrolló síndrome de distrés respiratorio agudo con hipoxemia refractaria a óxido nítrico y ventilación con alta frecuencia, necesitando oxigenación por membrana extracorpórea durante doce días. Se inició tratamiento con cefotaxima y vancomicina; tras identificación de Staphylococcus aureus resistente a meticilina (SARM) y sospecha de PVL, se cambió antibioterapia a ceftarolina y clindamicina. Además, recibió tratamiento con inmunoglobulinas y plasmaféresis. La TAC pulmonar a las 3 semanas de ingreso mostró múltiples abscesos pulmonares. Presentó mejoría progresiva con extubación a los 27 días de ingreso, sin complicaciones posteriores. Tras el alta, se mantiene asintomático desde el punto de vista respiratorio hasta la actualidad (1 año de vida).
CONCLUSIONES: Se ha producido un aumento en la incidencia de infecciones graves por SARM productor de PVL. Es importante sospecharlo en niños previamente sanos con empeoramiento respiratorio agudo y leucopenia. El tratamiento debe incluir un antibiótico anti-estafilocócico y uno con efecto anti-toxina.
On the Multidimensionality of Teachers’ Qualities, Personal Achievement, and their Role in Students’ Achievement in General Mathematics
Authors: Melchor Peter John M. , Suana Emma O. , Saldivar John Mark N.
Published: February 2025

This study was conducted to develop a valid and reliable tool that can be used to measure teachers' qualities and create a robust ordinal logistic regression model that predicts students' achievement in General Mathematics based on teachers' qualities and achievements as independent variables. The statistical tools used were the Reliability Test, Exploratory Factor Analysis, and Ordinal Regression Analysis. The researcher interviewed ten experienced mathematics teachers and ten senior high school students who recently finished General Mathematics. Their responses were then converted to measurable variables to construct an initial questionnaire. The initial questionnaire was pilot tested on 300 student respondents for reliability and was found reliable. Based on the results under Exploratory Factor Analysis, there are five latent variables/dimensions of teachers' qualities. These dimensions are Instructional Competencies, Personal Qualities, Procedural Fairness on Tests, Handling Learners' Response, and Compassionate Discipline. Moreover, the result of ordinal regression analysis explained five explanatory predictors that have significantly improved the Logistic Ordinal Regression Model. These five explanatory predictors were the Teacher's Years of Experience, the Teacher's Highest Educational Attainment, Personal Qualities, Procedural Fairness on Tests, and Handling Learners' Responses. With the highest Wald value of 5.842, Teachers' Personal Qualities significantly influenced student achievement in General Mathematics. Hence, teachers' attitudes in dealing with students should be seriously considered when aiming to increase the level of students' achievement in mathematics.
Potencial anti-estrés nitrosativo y oxidativo, y anti-inflamatorio de una fracción citoprotectora aisla-da de Litopenaeus stylirostris
Authors: García-Romo Joel Said , Martínez-Soto Juan Manuel , Hernández-Zazueta Martín Samuel , Sandoval-Petris Edgar , Plascencia-Jatomea Maribel , Burboa-Zazueta María Guadalupe , Robles-Sánchez Rosario Maribel , Santacruz-Ortega Hisila del Carmen , Candia-Plata Maria del Carmen , Parra-Vergara Norma-Violeta , Burgos-Hernández Armando
Published: February 2025

Se realizaron actividades biológicas de una fracción aislada del músculo de Litopenaeus stylirostris, la cual contiene un nuevo compuesto bioactivo derivado del alcaloide indolocarbazol, el ácido eicosapentaenoico y el dioctil ftalato. Se estudió la actividad eliminadora de especies reactivas de nitrógeno (ERN), la inhibición de la producción de óxido nítrico (ON), la reducción de especies reactivas de oxígeno (ERO) y la producción de citocinas reguladoras. Los resultados mostraron que la fracción disminuye los niveles de ERN, ON y ERO intracelulares; además, se encontró que es capaz de regular positivo y negativamente las citoquinas antiinflamatorias y proinflamatorias, respectivamente; lo que sugiere la presencia de compuestos que podrían estar asociados con disminuciones del estrés nitrosativo y oxidativo, así como con procesos de inflamación.
Sustainable Global Value Chain: The Case of IKEA
Authors: Korez Vide Romana , Hunjet Anica , Sesar Vesna
Published: February 2025

The increasing global fragmentation of production and the rise in cross-border transactions highlight the significance of tracing and understanding global value chains (GVCs). Discussing sustainability in GVCs demands a thorough examination of their intricate components. The value chain (VC) framework may be used to depict and advance sustainable paths of companies. There is a research gap in exploring sustainability implementation in the GVCs since there is no academic consensus on the relevant theoretical framework. In this case study, we link the business model and the value chain frameworks to explore the strategic and operational aspects of creating value through sustainability in the GVC. Studying the good practices of IKEA’s sustainable business model and GVC, our case study aims to provide a systematic approach to identifying value creation through cost-efficiency and differentiation in various upstream and downstream activities of the company’s value chain. We have found that this approach can increase the depth of GVC sustainability due diligence, improving insight into sustainability as a driver of a company's competitive advantages.
Host-dependent alteration of the gut microbiota: the role of luminal microRNAs
Authors: Cuinat Céline , Pan Jiali , Comelli Elena M.
Published: February 2025

MicroRNAs (miRNAs) are short, non-coding RNAs that play gene expression regulatory roles in eukaryotes. MiRNAs are also released in body fluids, and in the intestine, they are found in the lumen and feces. Here, together with exogenous dietary-derived miRNAs, they constitute the fecal miRNome. Several miRNAs were identified in the feces of healthy adults, including, as shown here, core miRNAs hsa-miR-21-5p and hsa-miR-1246. These miRNAs are important for intestinal homeostasis. Recent evidence suggests that miRNAs may interact with gut bacteria. This represents a new avenue to understand host-bacteria crosstalk in the gut and its role in health and disease. This review provides a comprehensive overview of current knowledge on fecal miRNAs, their representation across individuals, and their effects on the gut microbiota. It also discusses existing evidence on potential mechanisms of uptake and interaction with bacterial genomes, drawing from knowledge of prokaryotic small RNAs (sRNAs) regulation of gene expression. Finally, we review in silico and experimental approaches for profiling miRNA-mRNA interactions in bacterial species, highlighting challenges in target validation. This work emphasizes the need for further research into host miRNA-bacterial interactions to better understand their regulatory roles in the gut ecosystem and support their exploitation for disease prevention and treatment.
EXAMINING THE IMPACT OF WORK VALUES ON JOB SATISFACTION AND ORGANIZATIONAL CITIZENSHIP BEHAVIORS: A STUDY OF FIVESTAR HOTELS IN ISTANBUL
Authors: TÜRKAY Oğuz
Published: February 2025

Purpose –The attitude-behavior relationship between job satisfaction and OCBs in hotels
were defined previously. However the role of work values simultaneously on attitudes and
behaviors is unknown. The purpose of this research is to determine the role of work values in
organizational attitudes and behaviors.
Methodology/Design/Approach – It was tested how the intrinsic and extrinsic dimensions
of work values influence job satisfaction, organizational citizenship behaviors (OCBs) and
mutual interaction within a model drawn by considering the value-attitude-behavior pattern.
Data were gathered from 548 employees of 28 five-star hotels in Istanbul. LISREL was used
to test the structural model.
Findings – Intrinsic work values have positive effects on job satisfaction, OCB-I and OCB-O
while job satisfaction positively influences each of the two factors of OCBs. The effect of
extrinsic work values on job satisfaction and on OCB-I were not supported. Extrinsic work
value dimension has a positive effect on OCB-O.
Originality of the research – Because of its exploratory nature, this study was focused on the
pattern of value-attitude-behavior. Although the influence of work values on job satisfaction
and OCBs have been separately considered in related literature, the interaction between three
structures was analyzed together
Power Shifts and Knowledge Production: India’s Rise and Scholarship in International Relations
Authors: Hvid Aksel B. , Chagas-bastos Fabricio H. , Kristensen Peter Marcus
Published: February 2025

While much scholarly attention has been paid to the ways in which the rise of powers like China and India may challenge the fundamentals of the world order, there little empirically grounded research on the relationship between the socio-political conditions driving upward power shifts (“risingness”) and knowledge production, particularly outside the Western core of the International
Relations discipline. We show in this article that Indian scholars are more likely to portray India as a “rising power” when publishing in mainstream journals than when contributing to Indian journals. Moreover, Indian scholars publishing in mainstream journals often engage with a discourse centred on Western reference points, specifically addressing the future of the liberal international
order. By contrast, Indian scholars publishing in Indian journals focus on issues relevant to the South Asian context, frequently emphasising India’s non-Western roots. Finally, while contributions to mainstream journals tend to frame India’s rising status predominantly from a Western, particularly American, perspective, contributions to Indian journals are more deeply rooted in India’s rich intellectual traditions.
La traducción de la imagen en audiodescripción cuando vehicula contenido cultural
Authors: Valero Gisbert María J.
Published: February 2025

La traducción audiovisual (TAV), en sus distintas modalidades, se está expandiendo considerablemente gracias al desarrollo y aplicaciones tecnológicas que cada día revolucionan con nuevas propuestas, que sin duda requieren estudio, el mundo audiovisual. En esta investigación nos focalizaremos en una de las modalidades más recientes de la TAV: la audiodescripción (AD) y su aplicación a productos cinematográficos. Se afronta la cuestión de la descripción de imágenes que transmiten un contenido cultural, su transferencia al guion audiodescrito y el público al que se dirige, si se piensa únicamente en un usuario con discapacidad visual o se puede ampliar a una audiencia más generalizada. Tras una presentación esencial del concepto de referente cultural, se procederá a la exposición y análisis del material seleccionado. Se trata de fragmentos cinematográficos pertenecientes a culturas distantes entre sí. El fin último es analizar tanto el tipo de información que se consigna en la AD y su grado de comprensibilidad, como si está diseñada en función de un destinatario específico
Evaluación radiográfica de los protocolos diagnósticos de la enfermedad periodontal. Una revisión de la literatura
Authors:   , Gomez Aparicio Marlene Margot
Published: February 2025

El presente estudio tuvo por objetivo identificar los protocolos diagnósticos actuales de estudios por imágenes para la enfermedad periodontal (EP). Por ello, se desarrolló con un método de revisión de la literatura sistematizada, para lo cual se llevó a cabo la búsqueda bibliográfica en las bases de datos de artículos científicos en temáticas de salud: PubMed, Scopus y SciELO, cuyas palabras clave fueron cone beam computarized tomography, CBCT, periodontal disease, diagnosis, tomografía computarizada de haz cónico, TCHC, enfermedad periodontal, evaluación radiográfica y periodontitis. Los resultados identificaron las diferentes técnicas de imagenología para el diagnóstico de la EP en 2D y 3D, destacando la radiografía periapical digital, la radiografía bite wing, la técnica de sustracción digital, la radiografía panorámica y la tomografía computarizada de haz cónico (TCHC) para la evaluación del tejido alveolar, valorando la pérdida de inserción clínica (PIC), pérdida ósea (PO), la morfología de los defectos intraóseos y lesiones de furca (LF). Asimismo, se presentan los parámetros radiológicos para la radiografía periapical digital y radiografía panorámica en cuanto a Kv, mA, tiempo de adquisición, así como para la TCHC se adicionan los valores de campo de visión y voxel.
Evaluación externa del programa de tamizaje por mastografía en México, 2017
Authors: Romo-Dueñas Daniela , Ángeles–Llerenas Angélica , Uscanga–Sánchez Santos , Méndez de Lira José de Jesús , Torres–Mejía Gabriela , Hurtado-Salgado Erika , Saavedra-Lara Nenetzen , Lazcano-Ponce Eduardo
Published: February 2025

Objetivo. Analizar los resultados del programa de detección oportuna de cáncer de mama mediante tamizaje de la Secretaría de Salud en México (2017) a partir de seis indicadores de proceso comparados con la medición de 2011, así como con estándares de la Organización Mundial de la Salud. Material y métodos. Se midieron seis indicadores de proceso del programa: 1) población blanco a tamizar mediante mastografía; 2) proyección de infraestructura disponible para tamizaje; 3) cobertura de mastografía; 4) porcentaje de casos con evaluación especializada; 5) porcentaje de casos con malignidad lo suficientemente alta para realizar biopsia y confirmar diagnóstico; y 6) porcentaje de casos que inician tratamiento. Se compararon los indicadores con los de 2011 y con estándares internacionales. Se graficaron los indicadores del programa a nivel nacional y por grado de marginación. Resultados. Las coberturas de los últimos cinco indicadores fueron 38.1, 19.1, 13.3, 5.3 y 38.3%, respectivamente. En comparación con los últimos cinco indicadores de 2011, en los de 2017 se observó un incremento de 1.1, 4.1, 9.0, 3.2 y 37.1%, respectivamente. Conclusiones. Los resultados mostraron un bajo desempeño del programa de prevención y control del cáncer de mama. Se encontró una capacidad insuficiente para poder tamizar al total de la población de mujeres de 40 a 69 años usuarias de la Secretaría de Salud.
Intervención en salud sexual y reproductiva: impacto en prejuicios sobre la menstruación
Authors: Rodríguez Andrea , Campero Lourdes , Estrada Fátima
Published: February 2025

Objetivo. Analizar el impacto de una intervención educativa sobre salud sexual, reproductiva y menstrual para reducir prejuicios vinculados con la menstruación. Material y métodos. Estudio prospectivo cuasiexperimental con 351 adolescentes mujeres y hombres de secundaria de tres escuelas públicas en Morelos (225 control y 126 intervención). Se construyó un índice aditivo para identificar el cambio en percepción y prejuicios sobre la menstruación y se realizó un análisis de diferencias en diferencias para medir el impacto de la intervención en este indicador. Resultados. Se identificaron diferencias significativas iniciales en variables sociodemográficas entre los grupos, mismas que fueron incluidas en el modelo final. La intervención mostró efecto en la disminución de percepciones negativas y prejuicios en torno a la menstruación, observando un mayor efecto en las mujeres. Conclusión. Abordar la menstruación de manera explícita y comprensiva facilita una visión natural y sin prejuicios del funcionamiento del cuerpo.
Optimizing Wastewater Treatment with PVA Gel Beads and Pumice Stones: A Multi-Stage Reactor Approach
Authors: Chorey N. W. , Pawar Shantanu N.
Published: February 2025

Wastewater treatment is critical for public health and environmental protection, with materials and methods chosen based on wastewater layout, regulations, and treatment goals. PVA gel beads, a critical ingredient, are porous hydrogels with 95–98% water content and a specific gravity of 1.025 ± 0.01, which makes them perfect for immobilizing microorganisms needed to undergo pollutant breakdown. PVA gel beads' high porosity enhances oxygen and nutrient permeability, encouraging bacterial growth underneath the beads, decreasing biomass sloughing, and creating less extra sludge than older approaches. These beads, which may be used in both nitrification and denitrification operations, are non-biodegradable and effective in treating a variety of industrial pollutants. The manufacturing method includes creating a PVA solution, adding a crosslinking agent, emulsifying, inducing gelation, and filtering the beads. To restore function, the beads are swollen, rinsed, deswelled, crosslinked, and dried. PVA gel beads have several advantages, including successful mixing due to their near-water specific gravity, reduced sludge generation, and compatibility for a wide range of contaminants. However, they do have limits, such as low specificity for contaminants and the requirement for proper disposal after use. Artificial pumice stones, manufactured from cement, silica sand, and aluminium powder, are lightweight and porous, making them useful in building and water filtering. The experimental setup for this wastewater treatment system incorporates both attached and suspended growth techniques, with a lab-scale model using glass sheets for transparency. The system consists of an intake tank, aeration unit, PVA bioreactor, and sedimentation unit. The first research uses PVA gel beads as a biocarrier in the second reactor, with aeration promoting microorganism growth. In the second trial, pumice stones replaced PVA gel beads in the bioreactor. The third research uses PVA gel beads and pumice stones in the aeration and bioreactor units, respectively, to increase treatment efficiency by using both moving bed and fixed bed bioreactor procedures.