bluuebunny/crossref_metadata_2025 huggingface dataset:
Long-Term Outcome of Indomethacin Treatment in Pediatric Patients with Paroxysmal Hemicrania—A Case Series
Authors: Mauritz Maximilian David , Enninger Anna , Wamsler Christine , Wager Julia , Zernikow Boris
Published: February 2021

Paroxysmal Hemicrania is a rare form of primary headache in children and adolescents, belonging to the group of trigeminal autonomic cephalalgias. Patients suffer from severe, short-lasting unilateral headaches accompanied by symptoms of the autonomic system on the same side of the head. The short duration of attacks distinguishes Paroxysmal Hemicrania from other trigeminal autonomic cephalalgias. Indomethacin is the treatment of choice, and its effectiveness provides a unique diagnostic criterion. However, the long-term outcomes in children are highly underreported. In this case-series, n = 8 patients diagnosed with Paroxysmal Hemicrania were contacted via telephone 3.1 to 10.7 years after initial presentation. A standardized interview was conducted. n = 6 patients were headache-free and no longer took indomethacin for 5.4 ± 3.4 years. The mean treatment period in these patients was 2.2 ± 1.9 years. Weaning attempts were undertaken after 1.7 ± 1.3 months; in n = 3 patients, more than one weaning attempt was necessary. n = 2 patients were still taking indomethacin (4.5 and 4.9 years, respectively). Both unsuccessfully tried to reduce the indomethacin treatment (two and six times, respectively). Adverse effects appeared in n = 6 (75%) patients and led to a discontinuation of therapy in n = 2 patients. Our long-term follow-up suggests that in a substantial proportion of pediatric patients, discontinuing indomethacin therapy is possible without the recurrence of Paroxysmal Hemicrania.
COVID-19 Patient with Severe Comorbidity in Multimodal Acute Care Setting with Non-Invasive Medical Ventilation: A Clinical Outcome Report
Authors: Romeyke Tobias , Noehammer Elisabeth , Stummer Harald
Published: February 2021

The virus that causes COVID-19 is rapidly spreading across the globe. Elderly patients with multiple pre-existing conditions are at a higher risk. This case study describes acute inpatient treatment of a COVID-19 patient with uncontrolled diabetes mellitus, kidney complications, heart failure, chronic pain, depression, and other comorbidities in an isolation ward without mechanical ventilation.
Modeling and Electrical Characterization of a Bilayer Pt/AlN/Sapphire One Port Resonator for Sensor Applications
Authors: Jean Claude Asseko Ondo , Eloi Jean Jacques Blampain , Gaston N’tchayi Mbourou , Adoum Traore Ndama , Elysée Obame Ndong , Omar Elmazria
Published: February 2021

This paper presents a two-dimensional FEM (Finite Element Method) modeling and simulation of a surface acoustic wave (SAW) resonator based on a layered Pt/AlN/Sapphire structure. Such structure that exploits the electromechanical coupling of piezoelectric film is of high interest for harsh environments. By harsh environment we mean any environment that could hinder the operation of the device. Hardness can come from a variety of sources, and examples include the following: High pressure, High temperature, Shock/high vibration, Radiation, Harsh chemicals, etc. As part of this work, we are looking for high temperature sensor applications and only operating drifts due to temperature will be studied. SAW resonator is made from piezoelectric thin film Aluminum Nitride (AlN) layer on Sapphire substrate. Modal analysis is used to determine the eigen mode and the eigenfrequency of the system and the study of the frequency domain is used to determine the response of the model under influence of a harmonic excitation for one or more frequencies. In the FEM modeling, various parameters of the surface waves in the films, such as the surface velocity, the displacement of the piezoelectric thin film, the electrical potential, the electromechanical coefficient (k2), and the quality factor (Q) were studied. A comparative study between modeled and experimental curves showed a good agreement and allowed to validate our simulation method. Finally, a FEM study of the influence of normalized thickness of AlN thin film on resonator performances was carried out and compared with theorical results of literature.
Security of Supply in Gas and Hybrid Energy Networks
Authors: van der Linden Ruud , Octaviano Ryvo , Blokland Huib , Busking Tom
Published: February 2021

Reliable energy supply becomes increasingly complex in hybrid energy networks, due to increasing amounts of renewable electricity and more dynamic demand. Accurate modeling of integrated electricity and gas distribution networks is required to quantify operational bottlenecks in these networks and to increase security of supply. In this paper, we propose a hybrid network solver to model integrated electricity and gas distribution networks. A stochastic method is proposed to calculate the security of supply throughout the networks, taking into account the likelihood of events, operational constraints and dynamic supply and demand. The stochastic method is evaluated on a real gas network case study. The calculated security of supply parameters provide insight into the most critical parts of the network and can be used for future network planning. The capabilities of the coupled hybrid energy network simulation are demonstrated on the real gas network coupled to a simplified electricity network. Results demonstrate how combined simulation of electricity and gas networks facilitate the control design and performance evaluation of regional hybrid energy networks.
Effects of Pyrolysis Bio-Oils on Fuel Atomisation—A Review
Authors: Panchasara Heena , Ashwath Nanjappa
Published: February 2021

Bio-oils produced by biomass pyrolysis are substantially different from those produced by petroleum-based fuels and biodiesel. However, they could serve as valuable alternatives to fossil fuels to achieve carbon neutral future. The literature review indicates that the current use of bio-oils in gas turbines and compression-ignition (diesel) engines is limited due to problems associated with atomisation and combustion. The review also identifies the progress made in pyrolysis bio-oil spray combustion via standardisation of fuel properties, optimising atomisation and combustion, and understanding long-term reliability of engines. The key strategies that need to be adapted to efficiently atomise and combust bio-oils include, efficient atomisation techniques such as twin fluid atomisation, pressure atomisation and more advanced and novel effervescent atomisation, fuel and air preheating, flame stabilization using swrilers, and filtering the solid content from the pyrolysis oils. Once these strategies are implemented, bio-oils can enhance combustion efficiency and reduce greenhouse gas (GHG) emission. Overall, this study clearly indicates that pyrolysis bio-oils have the ability to substitute fossil fuels, but fuel injection problems need to be tackled in order to insure proper atomisation and combustion of the fuel.
Demand Response as a Real-Time, Physical Hedge for Retail Electricity Providers: The Electric Reliability Council of Texas Market Case Study
Authors: Blohm Andrew , Crawford Jaden , Gabriel Steven A.
Published: February 2021

Residential demand response (DR) programs are generally administered through an electricity distribution utility, or an electric grid operator. These programs typically reduce electricity consumption by inducing behavioral changes in the occupants of participating households. We propose implementing a wholesale-price-sensitive residential DR program through the retail electricity provider (REP), who has more naturally aligned incentives to avoid high wholesale electricity prices and maintain customer satisfaction, as compared to distribution utilities, grid operators, and the average residential consumer. Retail electricity providers who serve residential consumers are exposed to substantial price risk as they generally have a portion of their portfolio exposed to variable real-time wholesale electricity prices, despite charging their residential customers a fixed retail electricity price. Using Monte Carlo simulations, we demonstrate that demand response, executed through internet-connected thermostats, to shift real-time residential HVAC load in response to real-time prices, can be used as an effective physical hedge, which is both less costly and more effective than relying solely on financial hedging mechanisms. We find that on average a REP can avoid USD 62.07 annually per household using a load-shifting program. Given that REPs operate in a low margin industry, an annual avoided cost of this magnitude is not trivial.
Mechanical Forces Impacting Cleavage of Von Willebrand Factor in Laminar and Turbulent Blood Flow
Authors: Sharifi Alireza , Bark David
Published: February 2021

Von Willebrand factor (VWF) is a large multimeric hemostatic protein. VWF is critical in arresting platelets in regions of high shear stress found in blood circulation. Excessive cleavage of VWF that leads to reduced VWF multimer size in plasma can cause acquired von Willebrand syndrome, which is a bleeding disorder found in some heart valve diseases and in patients receiving mechanical circulatory support. It has been proposed that hemodynamics (blood flow) found in these environments ultimately leads to VWF cleavage. In the context of experiments reported in the literature, scission theory, developed for polymers, is applied here to provide insight into flow that can produce strong extensional forces on VWF that leads to domain unfolding and exposure of a cryptic site for cleavage through a metalloproteinase. Based on theoretical tensile forces, laminar flow only enables VWF cleavage when shear rate is large enough (>2800 s−1) or when VWF is exposed to constant shear stress for nonphysiological exposure times (>20 min). Predicted forces increase in turbulence, increasing the chance for VWF cleavage. These findings can be used when designing blood-contacting medical devices by providing hemodynamic limits to these devices that can otherwise lead to acquired von Willebrand syndrome.
Perilla frutescens Leaf Extract and Fractions: Polyphenol Composition, Antioxidant, Enzymes (α-Glucosidase, Acetylcholinesterase, and Tyrosinase) Inhibitory, Anticancer, and Antidiabetic Activities
Authors: Wang Zhenxing , Tu Zongcai , Xie Xing , Cui Hao , Kong Kin Weng , Zhang Lu
Published: February 2021

This study aims to evaluate the bioactive components, in vitro bioactivities, and in vivo hypoglycemic effect of P. frutescens leaf, which is a traditional medicine-food homology plant. P. frutescens methanol crude extract and its fractions (petroleum ether, chloroform, ethyl acetate, n-butanol fractions, and aqueous phase residue) were prepared by ultrasound-enzyme assisted extraction and liquid–liquid extraction. Among the samples, the ethyl acetate fraction possessed the high total phenolic (440.48 μg GAE/mg DE) and flavonoid content (455.22 μg RE/mg DE), the best antioxidant activity (the DPPH radical, ABTS radical, and superoxide anion scavenging activity, and ferric reducing antioxidant power were 1.71, 1.14, 2.40, 1.29, and 2.4 times higher than that of control Vc, respectively), the most powerful α-glucosidase inhibitory ability with the IC50 value of 190.03 μg/mL which was 2.2-folds higher than control acarbose, the strongest proliferative inhibitory ability against MCF-7 and HepG2 cell with the IC50 values of 37.92 and 13.43 μg/mL, which were considerable with control cisplatin, as well as certain inhibition abilities on acetylcholinesterase and tyrosinase. HPLC analysis showed that the luteolin, rosmarinic acid, rutin, and catechin were the dominant components of the ethyl acetate fraction. Animal experiments further demonstrated that the ethyl acetate fraction could significantly decrease the serum glucose level, food, and water intake of streptozotocin-induced diabetic SD rats, increase the body weight, modulate their serum levels of TC, TG, HDL-C, and LDL-C, improve the histopathology and glycogen accumulation in liver and intestinal tissue. Taken together, P. frutescens leaf exhibits excellent hypoglycemic activity in vitro and in vivo, and could be exploited as a source of natural antidiabetic agent.
Soft Mango Firmness Assessment Based on Rayleigh Waves Generated by a Laser-Induced Plasma Shock Wave Technique
Authors: Arai Nayuta , Miyake Masafumi , Yamamoto Kengo , Kajiwara Itsuro , Hosoya Naoki
Published: February 2021

Many methods based on acoustic vibration characteristics have been studied to indirectly assess fruit ripeness via fruit firmness. Among these, the frequency of the 0S2 vibration mode measured on the equator has been examined, but soft-flesh fruit do not show the 0S2 vibration mode. In this study, a Rayleigh wave is generated on a soft mango fruit using the impulse excitation force generated by a laser-induced plasma shock wave technique. Then, the flesh firmness of mangoes is assessed in a non-contact and non-destructive manner by observing the Rayleigh wave propagation velocity because it is correlated with the firmness (shear elasticity), density, and Poisson’s ratio of an object. If the changes in the density and Poisson’s ratio are small enough to be ignored during storage, then the Rayleigh wave propagation velocity is strongly correlated to fruit firmness. Here, we measure the Rayleigh wave propagation velocity and investigate the effect of storage time. Specifically, we investigate the changes in firmness caused by ripening. The Rayleigh wave propagation velocity on the equator of Kent mangoes tended to decrease by over 4% in 96 h. The Rayleigh wave measured on two different lines propagated independent distance and showed a different change rate of propagation velocity during 96-h storage. Furthermore, we consider the reliability of our method by investigating the interaction of a mango seed on the Rayleigh wave propagation velocity.
Web Search Engine Misinformation Notifier Extension (SEMiNExt): A Machine Learning Based Approach during COVID-19 Pandemic
Authors: Shams Abdullah Bin , Hoque Apu Ehsanul , Rahman Ashiqur , Sarker Raihan Md. Mohsin , Siddika Nazeeba , Preo Rahat Bin , Hussein Molla Rashied , Mostari Shabnam , Kabir Russell
Published: February 2021

Misinformation such as on coronavirus disease 2019 (COVID-19) drugs, vaccination or presentation of its treatment from untrusted sources have shown dramatic consequences on public health. Authorities have deployed several surveillance tools to detect and slow down the rapid misinformation spread online. Large quantities of unverified information are available online and at present there is no real-time tool available to alert a user about false information during online health inquiries over a web search engine. To bridge this gap, we propose a web search engine misinformation notifier extension (SEMiNExt). Natural language processing (NLP) and machine learning algorithm have been successfully integrated into the extension. This enables SEMiNExt to read the user query from the search bar, classify the veracity of the query and notify the authenticity of the query to the user, all in real-time to prevent the spread of misinformation. Our results show that SEMiNExt under artificial neural network (ANN) works best with an accuracy of 93%, F1-score of 92%, precision of 92% and a recall of 93% when 80% of the data is trained. Moreover, ANN is able to predict with a very high accuracy even for a small training data size. This is very important for an early detection of new misinformation from a small data sample available online that can significantly reduce the spread of misinformation and maximize public health safety. The SEMiNExt approach has introduced the possibility to improve online health management system by showing misinformation notifications in real-time, enabling safer web-based searching on health-related issues.
Stereoscopic Depth Perception and Visuospatial Dysfunction in Alzheimer’s Disease
Authors: Kim Nam-Gyoon , Lee Ho-Won
Published: February 2021

With visuospatial dysfunction emerging as a potential marker that can detect Alzheimer’s disease (AD) even in its earliest stages and with disturbance in stereopsis suspected to be the prime contributor to visuospatial deficits in AD, we assessed stereoscopic abilities of patients with AD and mild cognitive impairment (MCI). Whereas previous research assessing patients’ stereoacuity has yielded mixed results, we assessed patients’ capacity to process coarse disparities that can convey adequate depth information about objects in the environment. We produced two virtual cubes at two different distances from the observer by manipulating disparity type (absolute vs. relative), disparity direction (crossed vs. uncrossed) and disparity magnitude, then had participants judge the object that appeared closer to them. Two patient groups performed as well as, or even better than elderly controls, suggesting that AD patients’ coarse disparity processing capacity is capable of supporting common tasks involving reaching, grasping, driving, and navigation. Results may help researchers narrow down the exact cause(s) of visuospatial deficits in AD and develop and validate measures to assess visuospatial dysfunction in clinical trials and disease diagnosis.
Challenges and Obstacles Faced by Trainee Female Physicians: An Integrative Research on Gender Discrimination, Stress, Depression and Harassment
Authors: Yaghmour Aisha , Alesa Alaa , Anbarserry Esraa , Abdullah Binmerdah Merihan , Alharbi Ahlam , Housawi Abdulrahman , Almehdar Manal , Lytra Hara , Alsaywid Basim , Lytras Dimitrios M.
Published: February 2021

This study’s purpose is to assess the challenges and obstacles faced by female trainee physicians and suggest solutions that could resolve these issues and improve their performance. The study utilized an observational, analytical, cross-sectional design based on a self-administered open-ended and validated questionnaire which was distributed to 133 recruited female resident trainees of medical units in Jeddah, Saudi Arabia. The findings of the study revealed that 52% female trainees experienced gender discrimination, mostly (65%) by their superiors, while 40% were regularly harassed. About half (53%) of the interviewees were severely depressed, resulting in their reconsidering their career in medicine. A total of 14% thought of suicide, while four planned to end and five had attempted to end their life. However, only eight (6%) participants officially reported the cases of harassment to the accountable superiors. Half of them felt neglected by the healthcare administration, and one-fourth (24%) were underachieving in their studies and work. The study concluded that work dissatisfaction, limited clinical correspondence, high depression, burnout, stress and drop-out rates—all deriving from common gender discrimination—compose the alarming and complex challenges that female trainee residents in Jeddah of various levels and specialties have to face.
The Experiences of First-Time Fathers in Perinatal Services: Present but Invisible
Authors: Hodgson Suzanne , Painter Jon , Kilby Laura , Hirst Julia
Published: February 2021

Fathers in the UK are becoming more involved in the care of their infants and children. A constructivist grounded theory approach was adopted to explore men’s transition to fatherhood. This paper reports on one of the sub-categories derived from the data. First-time fathers with a child under two were recruited predominantly via social media. Audio-recorded semi-structured interviews were undertaken with an opening question asking men to tell their story of becoming a father. Interviews were transcribed and analysed using constructivist grounded theory methods. This paper reports one core aspect of the research findings which has particular relevance for healthcare professionals. The men in this study were highly appreciative of the care their partner and baby received but consistently reported a lack of father-specific support throughout their journey to fatherhood. This ranged from generally poor communication with healthcare professionals to being ignored and side-lined in maternity settings where they continued to be treated as visitors before, during and after the birth of their baby. Despite similar findings being reported over the last 30 to 40 years and policy directives emphasising the importance of working with fathers, change within healthcare services remains slow. Currently, fathers’ needs are not being adequately met by perinatal services.
Using the CES-D-7 as a Screening Instrument to Detect Major Depression among the Inmate Population
Authors: Juarros-Basterretxea Joel , Escoda-Menéndez Paula , Vilariño Manuel , Rodríguez-Díaz Francisco Javier , Herrero Juan
Published: February 2021

Major depression is one of the most prevalent mental health problems in the penitentiary context and has been related to different undesirable outcomes. The aim of the current research was to evaluate the utility of screening tools for major depression brief assessment in the jail context. We interviewed 203 male inmates and complimented the MCMI-III, the SCL-90-R, and the CES-D-7 self-informed scales. Major depression syndrome and disorder were determined based on MCMI-III criteria and the capability of SCL-90-R and CES-D-7 to identify true positives and true negatives when tested. SCL-90-R and CES-D-7 showed good sensitivity for major depression syndrome and disorder. The specificity of SCL-90-R was poor in all cases, but CES-D-7 showed good specificity depending on the cut-off score. Rigorous interviews are needed for better evaluation of major depression in jails, but screening tools like CES-D-7 are useful for rapid assessment considering the work overload of penitentiary psychologists.
Influence of Perceived Helicopter Parenting, Critical Thinking Disposition, Cognitive Ability, and Learning Motivation on Learning Behavior among Nursing Students
Authors: Oh Hyunjoo , Cho Haeryun , Yim So Youn
Published: February 2021

The purpose of this study was to determine the influence of perceived helicopter parenting, critical thinking disposition, cognitive ability, and learning motivation on learning behavior in nursing students in South Korea. The participants in this study were 149 sophomore nursing students from two universities using convenience sampling. The two universities were similar in terms of type, curricula, and size. Data were collected from October to November 2017 using self-reported questionnaires. The collected data were analyzed using descriptive statistics, Pearson correlation coefficients, and hierarchical multiple regression with SPSS 22.0. The mean score of perceived helicopter parenting was 3.06 ± 0.65 out of six points. The levels of critical thinking disposition, cognitive ability, learning motivation, and learning behavior were medium. Factors affecting learning behavior were learning motivation (β = 0.40, p < 0.001), cognitive ability (β = 0.26, p = 0.001), and critical thinking disposition (β = 0.25, p = 0.001). These variables explained 32% of the variance in learning behavior (F = 18.21, p < 0.001). Teaching methods are necessary to increase the critical thinking disposition and learning competence of nursing students. In addition, it is important to consider the learning motivation of nursing students for effective learning.
Adolescent Sexual and Reproductive Health Care Service Availability and Delivery in Public Health Facilities of Plateau State Nigeria
Authors: Envuladu Esther Awazzi , Massar Karlijn , de Wit John
Published: February 2021

To assess the availability, accessibility, appropriateness and quality of adolescent sexual and reproductive health (ASRH) services in primary health care (PHC) facilities in Plateau State, Nigeria, a cross-sectional study was conducted in 230 PHC facilities across the three senatorial zones of Plateau state. Primary data were obtained through face-to-face interviews with heads of facilities from December 2018 to May 2019. An adapted questionnaire from the World Health Organization (WHO) was used, covering five domains, to ascertain the extent that ASRH services were available and provided. Very few PHC facilities in the state had space (1.3%) and equipment (12.2%) for ASRH services. The proportion of PHC facilities offering counselling on sexuality was 11.3%, counselling on safe sex was 17%, counselling on contraception was 11.3% and management of gender-based violence was 3%. Most facilities were not operating at convenient times for adolescents. Only 2.6% PHC facilities had posters targeted at ASRH and just 7% of the PHCs had staff trained on ASRH. These findings underscore that the majority of PHC facilities surveyed in Plateau State, Nigeria, lacked dedicated space, basic equipment, and essential sexual and reproductive health care services for ASRH, which in turn negatively affect general public health and specifically, maternal health indices in Nigeria. Structural changes, including implementation of policy and adequate additional training of healthcare workers, are necessary to effectively promote ASRH.
Bayesian Weighted Sums: A Flexible Approach to Estimate Summed Mixture Effects
Authors: Hamra Ghassan B. , Maclehose Richard F. , Croen Lisa , Kauffman Elizabeth M. , Newschaffer Craig
Published: February 2021

Objectives: Methods exist to study exposure mixtures, but each is distinct in the research question it aims to address. We propose a new approach focused on estimating both the summed effect and individual weights of one or multiple exposure mixtures: Bayesian Weighted Sums (BWS). Methods: We applied BWS to simulated and real datasets with correlated exposures. The analytic context in our real-world example is an estimation of the association between polybrominated diphenyl ether (PBDE) congeners (28, 47, 99, 100, and 153) and Autism Spectrum Disorder (ASD) diagnosis and Social Responsiveness Scores (SRS). Results: Simulations demonstrate that BWS performs reliably. In adjusted models using Early Autism Risk Longitudinal Investigation (EARLI) data, the odds of ASD for a 1-unit increase in the weighted sum of PBDEs were 1.41 (95% highest posterior density 0.82, 2.50) times the odds of ASD for the unexposed and the change in z-score standardized SRS per 1 unit increase in the weighted sum of PBDEs is 0.15 (95% highest posterior density −0.08, 0.38). Conclusions: BWS provides a means of estimating the summed effect and weights for individual components of a mixture. This approach is distinct from other exposure mixture tools. BWS may be more flexible than existing approaches and can be specified to allow multiple exposure groups based on a priori knowledge from epidemiology or toxicology.
COVID-19 and the Political Economy of Mass Hysteria
Authors: Bagus Philipp , Peña-Ramos José Antonio , Sánchez-Bayón Antonio
Published: February 2021

In this article, we aim to develop a political economy of mass hysteria. Using the background of COVID-19, we study past mass hysteria. Negative information which is spread through mass media repetitively can affect public health negatively in the form of nocebo effects and mass hysteria. We argue that mass and digital media in connection with the state may have had adverse consequences during the COVID-19 crisis. The resulting collective hysteria may have contributed to policy errors by governments not in line with health recommendations. While mass hysteria can occur in societies with a minimal state, we show that there exist certain self-corrective mechanisms and limits to the harm inflicted, such as sacrosanct private property rights. However, mass hysteria can be exacerbated and self-reinforcing when the negative information comes from an authoritative source, when the media are politicized, and social networks make the negative information omnipresent. We conclude that the negative long-term effects of mass hysteria are exacerbated by the size of the state.
Financing Healthcare in Central and Eastern European Countries: How Far Are We from Universal Health Coverage?
Authors: Tambor Marzena , Klich Jacek , Domagała Alicja
Published: February 2021

After the fall of communism, the healthcare systems of Central and Eastern European countries underwent enormous transformation, resulting in departure from publicly financed healthcare. This had significant adverse effects on equity in healthcare, which are still evident. In this paper, we analyzed the role of government and households in financing healthcare in eight countries (EU-8): Czechia, Estonia, Hungary, Latvia, Lithuania, Poland, Slovakia, and Slovenia. A desk research method was applied to collect quantitative data on healthcare expenditures and qualitative data on gaps in universal health coverage. A linear regression analysis was used to analyze a trend in health expenditure over the years 2000–2018. Our results indicate that a high reliance on out-of-pocket payments persists in many EU-8 countries, and only a few countries have shown a significant downward trend over time. The gaps in universal coverage in the EU-8 countries are due to explicit rationing (a limited benefit package, patient cost sharing) and implicit mechanisms (wait times). There is need to increase the role of public financing in CEE countries through budget prioritization, reducing patient co-payments for medical products and medicines, and extending the benefit package for these goods, as well as improving the quality of care.
Prevalence of Fetal Alcohol Spectrum Disorders (FASD) among Children Adopted from Eastern European Countries: Russia and Ukraine
Authors: Colom Joan , Segura-García Lidia , Bastons-Compta Adriana , Astals Marta , Andreu-Fernandez Vicente , Barcons Natalia , Vidal Raquel , Ibar Ana I. , Fumadó Vicky , Gómez Nuria , Russiñol Agnés , Garcia-Algar Oscar
Published: February 2021

Fetal alcohol spectrum disorder (FASD) is a leading cause of neurodevelopmental disorders. Children adopted internationally from countries where alcohol consumption during pregnancy is very high are at greater risk for FASD. Lack of expertise in diagnosing FASD and mixed neurodevelopmental and behavioral signs due to abandonment complicate a timely diagnosis. The aim of this study was to determine the prevalence of FASD in adopted children. Children between the ages of 8 and 24 adopted from Russia and Ukraine were evaluated for clinical and historical features of FASD. Of the 162 children evaluated, 81 (50%) met FASD diagnostic criteria. Thirty-three (20.4%) children had fetal alcohol syndrome (FAS), 28 (17.2%) had partial FAS, 2 (1.2%) had alcohol-related birth defects (ARBD) and 18 (11.1%) had alcohol-related neurodevelopmental disorder (ARND). Of the 81 children in which fetal alcohol exposure could not be confirmed, many had manifestations that would have established a diagnosis of FASD if a history of maternal alcohol consumption was confirmed. In a population of children with a high risk of prenatal alcohol exposure (adoptees from Eastern European countries), at least 50% showed manifestations associated with FASD. The reported prevalence in this study is in line with the results obtained in a previous study as well as in orphanages of origin.
The Impact of COVID-19 on the Performance of Primary Health Care Service Providers in a Capitation Payment System: A Case Study from Poland
Authors: Korneta Piotr , Kludacz-Alessandri Magdalena , Walczak Renata
Published: February 2021

In Poland, as in many other countries, the use of capitation payment schemes in primary health care is popular. Despite this popularity, the subject literature discusses its role in decreasing the quality of primary medical services. This problem is particularly important during COVID-19, when medical entities provide telehealth services to patients. The objective of the study is to examine the effects of COVID-19 pandemic on the performance of the primary health care providers in Poland under a capitation payment scheme. In this study the authors use data from interviews with personnel of medical entities and financial and administrative reports of primary health care providers in order to identify how this crisis situation impacts the performance of primary health care entities, under capitation payment system. The performance indicators include both the financial and quality measures. Selected to the case study primary health care service providers significantly improved their profitability due to considerable costs savings and reduction of services provided to patients in a time of COVID-19 pandemic. Capitation payment system proved to be inefficient, in the studied pandemic period, in terms of the services provided by primary health care service providers to patients and the funds paid to them, in exchange, by the government entities.
Evaluation of Anxiety, Suicidal Risk, Daily Stress, Empathy, Perceived Emotional Intelligence, and Coping Strategies in a Sample of Spanish Undergraduates
Authors: Montero Estefanía Solla , Morales-Rodríguez Francisco Manuel
Published: February 2021

Anxiety disorders and suicide are commonly under-recognized issues that can be a public health problem. Adolescents are among the most affected population groups and studying them can prevent serious health problems. These two elements are related, but at the same time, they can only be understood from a multifactorial point of view, so other related variables such as emotional intelligence, empathy, or coping strategies are key to understand their effect on the population. In this study, a series of methods to measure the variables of interest were applied to a specific group of adolescents to determine their mental health levels, focusing on suicide and anxiety episodes. The results reflected average levels with a tendency to be high in the case of anxiety and nonalarming levels in terms of suicide risk, both parameters presenting more worrying values in women. In turn, the correlation between suicide and anxiety was demonstrated considering the other variables (coping strategies, empathy, emotional intelligence, and prosociality). This research has relevant implications for the diagnosis, orientation, and design of psychoeducational and clinical interventions that contribute to the improvement of their well-being and quality of life.
Mental Health and Psychological Impact on Students with or without Hearing Loss during the Recurrence of the COVID-19 Pandemic in China
Authors: Yang Ying , Xiao Yanan , Liu Yulu , Li Qiong , Shan Changshuo , Chang Shulin , Jen Philip H.-S.
Published: February 2021

Background: This study compares the mental health and psychological response of students with or without hearing loss during the recurrence of the COVID-19 pandemic in Beijing, the capital of China. It explores the relevant factors affecting mental health and provides evidence-driven strategies to reduce adverse psychological impacts during the COVID-19 pandemic. Methods: We used the Chinese version of depression, anxiety, and stress scale 21 (DASS-21) to assess the mental health and the impact of events scale—revised (IES-R) to assess the COVID-19 psychological impact. Results: The students with hearing loss are frustrated with their disability and particularly vulnerable to stress symptoms, but they are highly endurable in mitigating this negative impact on coping with their well-being and responsibilities. They are also more resilient psychologically but less resistant mentally to the pandemic impacts than the students with normal hearing. Their mental and psychological response to the pandemic is associated with more related factors and variables than that of the students with normal hearing is. Conclusions: To safeguard the welfare of society, timely information on the pandemic, essential services for communication disorders, additional assistance and support in mental counseling should be provided to the vulnerable persons with hearing loss that are more susceptible to a public health emergency.
Therapeutic Potential of Regorafenib—A Multikinase Inhibitor in Pulmonary Hypertension
Authors: Veeroju Swathi , Kojonazarov Baktybek , Weiss Astrid , Ghofrani Hossein Ardeschir , Weissmann Norbert , Grimminger Friedrich , Seeger Werner , Novoyatleva Tatyana , Schermuly Ralph Theo
Published: February 2021

Pulmonary hypertension (PH) is characterized by a progressive elevation of mean arterial pressure followed by right ventricular failure and death. Previous studies have indicated that numerous inhibitors of receptor tyrosine kinase signaling could be either beneficial or detrimental for the treatment of PH. Here we investigated the therapeutic potential of the multi-kinase inhibitor regorafenib (BAY 73-4506) for the treatment of PH. A peptide-based kinase activity assay was performed using the PamStation®12 platform. The 5-bromo-2′-deoxyuridine proliferation and transwell migration assays were utilized in pulmonary arterial smooth muscle cells (PASMCs). Regorafenib was administered to monocrotaline- and hypoxia-induced PH in rats and mice, respectively. Functional parameters were analyzed by hemodynamic and echocardiographic measurements. The kinase activity assay revealed upregulation of twenty-nine kinases in PASMCs from patients with idiopathic PAH (IPAH), of which fifteen were established as potential targets of regorafenib. Regorafenib showed strong anti-proliferative and anti-migratory effects in IPAH-PASMCs compared to the control PASMCs. Both experimental models indicated improved cardiac function and reduced pulmonary vascular remodeling upon regorafenib treatment. In lungs from monocrotaline (MCT) rats, regorafenib reduced the phosphorylation of c-Jun N-terminal kinase and extracellular signal-regulated kinase 1/2. Overall, our data indicated that regorafenib plays a beneficial role in experimental PH.
The Space of Disse: The Liver Hub in Health and Disease
Authors: Sanz-García Carlos , Fernández-Iglesias Anabel , Gracia-Sancho Jordi , Arráez-Aybar Luis Alfonso , Nevzorova Yulia A. , Cubero Francisco Javier
Published: February 2021

Since it was first described by the German anatomist and histologist, Joseph Hugo Vincenz Disse, the structure and functions of the space of Disse, a thin perisinusoidal area between the endothelial cells and hepatocytes filled with blood plasma, have acquired great importance in liver disease. The space of Disse is home for the hepatic stellate cells (HSCs), the major fibrogenic players in the liver. Quiescent HSCs (qHSCs) store vitamin A, and upon activation they lose their retinol reservoir and become activated. Activated HSCs (aHSCs) are responsible for secretion of extracellular matrix (ECM) into the space of Disse. This early event in hepatic injury is accompanied by loss of the pores—known as fenestrations—of the endothelial cells, triggering loss of balance between the blood flow and the hepatocyte, and underlies the link between fibrosis and organ dysfunction. If the imbalance persists, the expansion of the fibrotic scar followed by the vascularized septae leads to cirrhosis and/or end-stage hepatocellular carcinoma (HCC). Thus, researchers have been focused on finding therapeutic targets that reduce fibrosis. The space of Disse provides the perfect microenvironment for the stem cells niche in the liver and the interchange of nutrients between cells. In the present review article, we focused on the space of Disse, its components and its leading role in liver disease development.
The Relativistic Harmonic Oscillator in a Uniform Gravitational Field
Authors: Tung Michael M.
Published: February 2021

We present the relativistic generalization of the classical harmonic oscillator suspended within a uniform gravitational field measured by an observer in a laboratory in which the suspension point of the spring is fixed. The starting point of this analysis is a variational approach based on the Euler–Lagrange formalism. Due to the conceptual differences of mass in the framework of special relativity compared with the classical model, the correct treatment of the relativistic gravitational potential requires special attention. It is proved that the corresponding relativistic equation of motion has unique periodic solutions. Some approximate analytical results including the next-to-leading-order term in the non-relativistic limit are also examined. The discussion is rounded up with a numerical simulation of the full relativistic results in the case of a strong gravity field. Finally, the dynamics of the model is further explored by investigating phase space and its quantitative relativistic features.
Mechanical and Morphological Properties of Bio-Phenolic/Epoxy Polymer Blends
Authors: Ismail Ahmad Safwan , Jawaid Mohammad , Hamid Norul Hisham , Yahaya Ridwan , Hassan Azman
Published: February 2021

Polymer blends is a well-established and suitable method to produced new polymeric materials as compared to synthesis of a new polymer. The combination of two different types of polymers will produce a new and unique material, which has the attribute of both polymers. The aim of this work is to analyze mechanical and morphological properties of bio-phenolic/epoxy polymer blends to find the best formulation for future study. Bio-phenolic/epoxy polymer blends were fabricated using the hand lay-up method at different loading of bio-phenolic (5 wt%, 10 wt%, 15 wt%, 20 wt%, and 25 wt%) in the epoxy matrix whereas neat bio-phenolic and epoxy samples were also fabricated for comparison. Results indicated that mechanical properties were improved for bio-phenolic/epoxy polymer blends compared to neat epoxy and phenolic. In addition, there is no sign of phase separation in polymer blends. The highest tensile, flexural, and impact strength was shown by P-20(biophenolic-20 wt% and Epoxy-80 wt%) whereas P-25 (biophenolic-25 wt% and Epoxy-75 wt%) has the highest tensile and flexural modulus. Based on the finding, it is concluded that P-20 shows better overall mechanical properties among the polymer blends. Based on this finding, the bio-phenolic/epoxy blend with 20 wt% will be used for further study on flax-reinforced bio-phenolic/epoxy polymer blends.
Polyphenols’ Cardioprotective Potential: Review of Rat Fibroblasts as Well as Rat and Human Cardiomyocyte Cell Lines Research
Authors: Otręba Michał , Kośmider Leon , Rzepecka-Stojko Anna
Published: February 2021

According to the World Health Organization, cardiovascular diseases are responsible for 31% of global deaths. A reduction in mortality can be achieved by promoting a healthy lifestyle, developing prevention strategies, and developing new therapies. Polyphenols are present in food and drinks such as tea, cocoa, fruits, berries, and vegetables. These compounds have strong antioxidative properties, which might have a cardioprotective effect. The aim of this paper is to examine the potential of polyphenols in cardioprotective use based on in vitro human and rat cardiomyocytes as well as fibroblast research. Based on the papers discussed in this review, polyphenols have the potential for cardioprotective use due to their multilevel points of action which include, among others, anti-inflammatory, antioxidant, antithrombotic, and vasodilatory. Polyphenols may have potential use in new and effective preventions or therapies for cardiovascular diseases, yet more clinical studies are needed.
An Insight into the Anti-Angiogenic and Anti-Metastatic Effects of Oridonin: Current Knowledge and Future Potential
Authors: Abdullah Nurul Akmaryanti , Md Hashim Nur Fariesha , Ammar Aula , Muhamad Zakuan Noraina
Published: February 2021

Cancer is one of the leading causes of death worldwide, with a mortality rate of more than 9 million deaths reported in 2018. Conventional anti-cancer therapy can greatly improve survival however treatment resistance is still a major problem especially in metastatic disease. Targeted anti-cancer therapy is increasingly used with conventional therapy to improve patients’ outcomes in advanced and metastatic tumors. However, due to the complexity of cancer biology and metastasis, it is urgent to develop new agents and evaluate the anti-cancer efficacy of available treatments. Many phytochemicals from medicinal plants have been reported to possess anti-cancer properties. One such compound is known as oridonin, a bioactive component of Rabdosia rubescens. Several studies have demonstrated that oridonin inhibits angiogenesis in various types of cancer, including breast, pancreatic, lung, colon and skin cancer. Oridonin’s anti-cancer effects are mediated through the modulation of several signaling pathways which include upregulation of oncogenes and pro-angiogenic growth factors. Furthermore, oridonin also inhibits cell migration, invasion and metastasis via suppressing epithelial-to-mesenchymal transition and blocking downstream signaling targets in the cancer metastasis process. This review summarizes the recent applications of oridonin as an anti-angiogenic and anti-metastatic drug both in vitro and in vivo, and its potential mechanisms of action.
Celebrating Todd Marder: 65th Birthday and His Contributions to Inorganic Chemistry
Authors: Kakkar Ashok
Published: February 2021

Professor Todd B [...]
A Neutralization Assay Based on Pseudo-Typed Lentivirus with SARS CoV-2 Spike Protein in ACE2-Expressing CRFK Cells
Authors: Pısıl Yalçın , Shida Hisatoshi , Miura Tomoyuki
Published: February 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly pathogenic zoonotic virus that spreads rapidly. In this work, we improve the hitherto existing neutralization assay system to assess SARS-CoV-2 inhibitors using a pseudo-typed lentivirus coated with the SARS-CoV-2 spike protein (LpVspike +) and angiotensin-converting enzyme 2 (ACE2)-transfected cat Crandell–Rees feline kidney (CRFK) cells as the host cell line. Our method was 10-fold more sensitive compared to the typical human embryonic kidney 293T (HEK293T) cell system, and it was successfully applied to quantify the titers of convalescent antisera and monoclonal anti-spike antibodies required for pseudo virus neutralization. The 50% inhibition dilution (ID50) of two human convalescent sera, SARS-CoV-2 immunoglobulin G (IgG) and SARS-CoV-2 immunoglobulin M (IgM), which were 1:350 (±1:20) and 1:1250 (±1:350), respectively. The 50% inhibitory concentration (IC50) of the IgG, IgM and immunoglobulin A (IgA) anti-SARS-CoV-2 monoclonal antibodies (mAbs) against LpVspike(+) were 0.45 (±0.1), 0.002 (±0.001) and 0.004 (±0.001) µg mL−1, respectively. We also found that reagents typically used to enhance infection were not effective in the CFRK system. This methodology is both efficient and safe; it can be employed by researchers to evaluate neutralizing monoclonal antibodies and contribute to the discovery of new antiviral inhibitors against SARS-CoV-2.
Dilemma Zone: Modeling Drivers’ Decision at Signalized Intersections against Aggressiveness and Other Factors Using UAV Technology
Authors: Papaioannou Panagiotis , Papadopoulos Efthymis , Nikolaidou Anastasia , Politis Ioannis , Basbas Socrates , Kountouri Eleni
Published: February 2021

Intersection safety and drivers’ behavior are strongly interrelated, especially when the latter are located in dilemma zone. This paper explores, among others, the main factors affecting driver behavior, such as distance to stop line, approaching speed and acceleration/deceleration, and two additional factors, namely, driver’s aggressiveness and driver’s relative position at the onset of the yellow signal. Field data were collected using unmanned aerial vehicle (UAV) technology. Two binary choice models were developed, the first relying on observed data and the latter enriched by the latent factor drivers’ aggressiveness and the vehicles’ relative position. Drivers were classified to aggressive and non-aggressive ones using a latent class model that combined approaching speed and acceleration/deceleration data. Drivers were further grouped according to their expected reaction/decision to stop or cross the intersection in relation to their relative position. Both models equally explain drivers’ decisions adequately, but the second one offers additional explanatory power attributed to aggressiveness. Being able to identify the level of aggressiveness among the drivers enables the calculation of the probability that drivers will cross the intersection even if caught in a dilemma zone or in a zone in which the obvious decision is to stop. Such findings can be valuable when designing a signalized intersection and the traffic time settings, as well as the posted speed limit.