bluuebunny/crossref_metadata_2025 huggingface dataset:
Warfarin maintenance dose Prediction for Patients undergoing heart valve replacement— a hybrid model with genetic algorithm and Back-Propagation neural network
Authors: Li Qian , Tao Huan , Wang Jing , Zhou Qin , Chen Jie , Qin Wen Zhe , Dong Li , Fu Bo , Hou Jiang Long , Chen Jin , Zhang Wei-Hong
Published: June 2018

Warfarin is the most recommended anticoagulant drug for patients undergoing heart valve replacement. However, due to the narrow therapeutic window and individual dose, the use of warfarin needs more advanced technology. We used the data collected from a multi-central registered clinical system all over China about the patients who have undergone heart valve replacement, subsequently divided into three groups (training group: 10673 cases; internal validation group: 3558 cases; external validation group: 1463 cases) in order to construct a hybrid model with genetic algorithm and Back-Propagation neural network (BP-GA), For testing the model’s prediction accuracy, we used Mean absolute error (MAE), Root mean squared error (RMSE) and the ideal predicted percentage of total and dose subgroups. In results, whether in internal or in external validation group, the total ideal predicted percentage was over 58% while the intermediate dose subgroup manifested the best. Moreover, it showed higher prediction accuracy, lower MAE value and lower RMSE value in the external validation group than that in the internal validation group (p < 0.05). In conclusion, BP-GA model is promising to predict warfarin maintenance dose.
Author Correction: Optimization of Magneto-thermally Controlled Release Kinetics by Tuning of Magnetoliposome Composition and Structure
Authors: Shirmardi Shaghasemi Behzad , Virk Mudassar Mumtaz , Reimhult Erik
Published: June 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
C2orf71a/pcare1 is important for photoreceptor outer segment morphogenesis and visual function in zebrafish
Authors: Corral-Serrano Julio C. , Messchaert Muriël , Dona Margo , Peters Theo A. , Kamminga Leonie M. , van Wijk Erwin , Collin Rob W. J.
Published: June 2018

Mutations in C2orf71 are causative for autosomal recessive retinitis pigmentosa and occasionally cone-rod dystrophy. We have recently discovered that the protein encoded by this gene is important for modulation of the ciliary membrane through the recruitment of an actin assembly module, and have therefore renamed the gene to PCARE (photoreceptor cilium actin regulator). Here, we report on the identification of two copies of the c2orf71/pcare gene in zebrafish, pcare1 and pcare2. To study the role of the gene most similar to human PCARE, pcare1, we have generated a stable pcare1 mutant zebrafish model (designated pcare1
rmc100/rmc100
) in which the coding sequence was disrupted using CRISPR/Cas9 technology. Retinas of both embryonic (5 dpf) and adult (6 mpf) pcare1
rmc100/rmc100
zebrafish display a clear disorganization of photoreceptor outer segments, resembling the phenotype observed in Pcare−/− mice. Optokinetic response and visual motor response measurements indicated visual impairment in pcare1
rmc100/rmc100
zebrafish larvae at 5 dpf. In addition, electroretinogram measurements showed decreased b-wave amplitudes in pcare1
rmc100/rmc100
zebrafish as compared to age- and strain-matched wild-type larvae, indicating a defect in the transretinal current. Altogether, our data show that lack of pcare1 causes a retinal phenotype in zebrafish and indicate that the function of the PCARE gene is conserved across species.
Linking minimum inhibitory concentrations to whole genome sequence-predicted drug resistance in Mycobacterium tuberculosis strains from Romania
Authors: Ruesen Carolien , Riza Anca Lelia , Florescu Adriana , Chaidir Lidya , Editoiu Cornelia , Aalders Nicole , Nicolosu Dragos , Grecu Victor , Ioana Mihai , van Crevel Reinout , van Ingen Jakko
Published: June 2018

Mycobacterium tuberculosis drug resistance poses a major threat to tuberculosis control. Current phenotypic tests for drug susceptibility are time-consuming, technically complex, and expensive. Whole genome sequencing is a promising alternative, though the impact of different drug resistance mutations on the minimum inhibitory concentration (MIC) remains to be investigated. We examined the genomes of 72 phenotypically drug-resistant Mycobacterium tuberculosis isolates from 72 Romanian patients for drug resistance mutations. MICs for first- and second-line drugs were determined using the MycoTB microdilution method. These MICs were compared to macrodilution critical concentration testing by the Mycobacterium Growth Indicator Tube (MGIT) platform and correlated to drug resistance mutations. Sixty-three (87.5%) isolates harboured drug resistance mutations; 48 (66.7%) were genotypically multidrug-resistant. Different drug resistance mutations were associated with different MIC ranges; katG S315T for isoniazid, and rpoB S450L for rifampicin were associated with high MICs. However, several mutations such as in rpoB, rrs and rpsL, or embB were associated with MIC ranges including the critical concentration for rifampicin, aminoglycosides or ethambutol, respectively. Different resistance mutations lead to distinct MICs, some of which may still be overcome by increased dosing. Whole genome sequencing can aid in the timely diagnosis of Mycobacterium tuberculosis drug resistance and guide clinical decision-making.
Cerebral photoreception in mantis shrimp
Authors: Donohue Mary W. , Cohen Jonathan H. , Cronin Thomas W.
Published: June 2018

The currently unsurpassed diversity of photoreceptors found in the eyes of stomatopods, or mantis shrimps, is achieved through a variety of opsin-based visual pigments and optical filters. However, the presence of extraocular photoreceptors in these crustaceans is undescribed. Opsins have been found in extraocular tissues across animal taxa, but their functions are often unknown. Here, we show that the mantis shrimp Neogonodactylus oerstedii has functional cerebral photoreceptors, which expands the suite of mechanisms by which mantis shrimp sense light. Illumination of extraocular photoreceptors elicits behaviors akin to common arthropod escape responses, which persist in blinded individuals. The anterior central nervous system, which is illuminated when a mantis shrimp’s cephalothorax protrudes from its burrow to search for predators, prey, or mates, appears to be photosensitive and to feature two types of opsin-based, potentially histaminergic photoreceptors. A pigmented ventral eye that may be capable of color discrimination extends from the cerebral ganglion, or brain, against the transparent outer carapace, and exhibits a rapid electrical response when illuminated. Additionally, opsins and histamine are expressed in several locations of the eyestalks and cerebral ganglion, where any photoresponses could contribute to shelter-seeking behaviors and other functions.
Sodium orthovanadate overcomes sorafenib resistance of hepatocellular carcinoma cells by inhibiting Na+/K+-ATPase activity and hypoxia-inducible pathways
Authors: Jiang Wenjing , Li Guangxin , Li Weidong , Wang Ping , Xiu Peng , Jiang Xian , Liu Bing , Sun Xueying , Jiang Hongchi
Published: June 2018

The resistance to sorafenib highly affects its clinical benefits for treating hepatocellular carcinoma (HCC). Sodium orthovanadate (SOV) is a phosphate analog that displays anti-cancer activities against various types of malignancies including HCC. The present study has demonstrated that SOV is able to overcome sorafenib resistance and strengthens sorafenib in suppressing sorafenib-resistant HCC cells in vitro and in animal models. Similar to its action on parental HCC cells, SOV induced cell cycle arrest at G2/M phases by regulating cyclin B1 and cyclin-dependent kinase 1, and apoptosis by reducing mitochondrial membrane potential, in sorafenib-resistant HCC cells. More importantly, SOV inhibited ATPase activity, which was significantly elevated in sorafenib-resistant HCC cells. SOV also reduced the expression of HIF-1α and HIF-2α and their nuclear translocation, resulting in downregulation of their downstream factors including vascular endothelial growth factor, lactate dehydrogenase-A and glucose transporter 1. Its ability to inhibit ATPase activity and hypoxia-inducible pathways enabled SOV to efficiently suppress both normoxic and hypoxic cells, which compose cancer cell populations inside sorafenib-resistant HCC tumors. The present results indicate that SOV may be a potent candidate drug for overcoming the resistance to sorafenib in treating HCC.
Neuroprotective effects of Magnoliae Flos extract in mouse hippocampal neuronal cells
Authors: Jung Youn Sik , Weon Jin Bae , Yang Woo Seung , Ryu Gahee , Ma Choong Je
Published: June 2018

Magnoliae Flos (MF) is a traditional medicinal herb used for managing rhinitis, sinusitis and headache. The purpose of the present study was to determine the neuroprotective effect of MF against glutamate-induced oxidative stress and to assess the underlying mechanism. Glutamate is a major endogenous excitatory neurotransmitter in the brain and contributes to the development of neurodegenerative diseases by excessive activation. MF extract was subjected to a neuroprotective effect assay in HT22 mouse hippocampal cells. The mechanism underlying the neuroprotective effect of MF extract was evaluated by assaying reactive oxygen species (ROS) levels, intracellular Ca2+ levels, mitochondrial membrane potential, glutathione level and antioxidant enzyme activity in HT22 cells. MF extract significantly decreased glutamate-induced death of HT22 cells (80.83 ± 7.34% relative neuroprotection). MF extract reduced the intracellular ROS and Ca2+ levels and increased the glutathione level and glutathione reductase and glutathione peroxide activities. Moreover, MF extract attenuated the mitochondrial membrane potential in HT22 cells. These results suggested that MF extract exerts a neuroprotective effect against oxidative stress HT22 cells, which was mediated by its antioxidant activity.
Efficacy of commercial vaccines against newly emerging avian influenza H5N8 virus in Egypt
Authors: Kandeil Ahmed , Sabir Jamal S. M. , Abdelaal Ahmed , Mattar Ehab H. , El-Taweel Ahmed N. , Sabir Mumdooh J. , Khalil Ahmed Aly , Webby Richard , Kayali Ghazi , Ali Mohamed A.
Published: June 2018

The newly emerging, highly pathogenic avian influenza (HPAI) H5N8 virus of clade 2.3.4.4 was recently detected in wild birds and domestic poultry in Egypt in the 2016/2017 winter season. Vaccination based on commercial H5 vaccines is used as an essential control strategy in Egyptian poultry. Here, we studied the efficacy of the eight most common commercial H5 poultry vaccines in the Egyptian market and compared them with an experimental vaccine based on the Egyptian LPAI H5N8 virus that was prepared by using reverse genetics. The experimental vaccine and Re-5 commercial vaccine were able to completely protect chickens and significantly reduce virus shedding. Our results indicate that most of the commercial poultry H5 vaccines used in the present study were ineffective because the seed viruses in these vaccines are genetically distinct from the H5N8 viruses currently circulating in Egypt. Although some of the commercial vaccines protected chickens from mortality, they failed to prevent chickens from shedding the virus. Accordingly, we recommend updating and reinforcing the H5N8 prevention and control strategies in Egypt. The vaccination strategy should be reconsidered based on currently circulating viruses.
Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction
Authors: Russo Valerio , Klein Theo , Lim Darielle J. , Solis Nestor , Machado Yoan , Hiroyasu Sho , Nabai Layla , Shen Yue , Zeglinski Matthew R. , Zhao Hongyan , Oram Cameron P. , Lennox Peter A. , Van Laeken Nancy , Carr Nick J. , Crawford Richard I. , Franzke Claus-Werner , Overall Christopher M. , Granville David J.
Published: June 2018

In healthy skin, epidermis and dermis are anchored together at the dermal-epidermal junction (DEJ), a specialized basement membrane pivotal for skin integrity and function. However, increased inflammation in the DEJ is associated with the disruption and separation of this junction and sub-epidermal blistering. Granzyme B (GzmB) is a serine protease secreted by immune cells. Dysregulated inflammation may lead to increased GzmB accumulation and proteolysis in the extracellular milieu. Although elevated GzmB is observed at the level of the DEJ in inflammatory and blistering skin conditions, the present study is the first to explore GzmB in the context of DEJ degradation in autoimmune sub-epidermal blistering. In the present study, GzmB induced separation of the DEJ in healthy human skin. Subsequently, α6/β4 integrin, collagen VII, and collagen XVII were identified as extracellular substrates for GzmB through western blot, and specific cleavage sites were identified by mass spectrometry. In human bullous pemphigoid, dermatitis herpetiformis, and epidermolysis bullosa acquisita, GzmB was elevated at the DEJ when compared to healthy samples, while α6/β4 integrin, collagen VII, and collagen XVII were reduced or absent in the area of blistering. In summary, our results suggest that regardless of the initial causation of sub-epidermal blistering, GzmB activity is a common final pathway that could be amenable to a single targeted treatment approach.
Continuous flow biocatalysis
Authors: Britton Joshua , Majumdar Sudipta , Weiss Gregory A.
Published: June 2018

Merging the power of proteins and continuous flow for improved chemical synthesis.
Cathodic electrochemiluminescence behaviour of MoS2 quantum dots and its biosensing of microRNA-21
Authors: Cao Jun-Tao , Liu Fu-Rao , Hou Fang , Peng Juan , Ren Shu-Wei , Liu Yan-Ming
Published: June 2018

The cathodic electrochemiluminescence (ECL) behaviour of nontoxic MoS2 quantum dots (QDs) was studied for the first time using potassium peroxydisulfate as the co-reactant.
A dual-analyte probe: hypoxia activated nitric oxide detection with phototriggered drug release ability
Authors: Biswas Sandipan , Rajesh Y. , Barman Shrabani , Bera Manoranjan , Paul Amrita , Mandal Mahitosh , Pradeep Singh N. D.
Published: June 2018

A new strategy for the detection of hypoxia and NO succeeded by photocontrolled delivery of an anticancer agent has been demonstrated.
A ruthenium–platinum metal complex that binds to sarcin ricin loop RNA and lowers mRNA expression
Authors: Jain Swapan S. , Anderson Craig M. , Sapse Iden A. , Lundgren Silvie H. , Freer Abigail K. , Hoang Hang , Jain Kyan , Breshears Madeleine
Published: June 2018

IT127 is a dinuclear transition metal complex that binds to purine bases in RNA and inhibits protein translation.
Hyper-cross-linked polymers with controlled multiscale porosity via polymerization-induced microphase separation within high internal phase emulsion
Authors: Park Jongmin , Kim KyuHan , Seo Myungeun
Published: June 2018

Porous polymers containing hierarchically organized, interconnected, and controlled micro-, meso- and macropores allow the effective adsorption of dye molecules from solution.
One-step synthesis of cyclic compounds towards easy room-temperature phosphorescence and deep blue thermally activated delayed fluorescence
Authors: Hu Yingyuan , Wang Zhenfeng , Jiang Xiaofang , Cai Xinyi , Su Shi-Jian , Huang Fei , Cao Yong
Published: June 2018

Novel cyclic compounds were synthesized by one-pot synthesis and THF-irrigating purification with deep blue thermally activated delayed fluorescence and room-temperature phosphorescence dual emission.
Ultra-sensitive fluorescent probes for hypochlorite acid detection and exogenous/endogenous imaging of living cells
Authors: Jiang Yin , Zheng Guansheng , Duan Qinya , Yang Liu , Zhang Jie , Zhang Huatang , He Jun , Sun Hongyan , Ho Derek
Published: June 2018

Two fluorescent probes have been developed to detect HOCl with ultra-high sensitivity and employed to image exogenous/endogenous HOCl in living cells.
Two interpenetrated metal–organic frameworks with a slim ethynyl-based ligand: designed for selective gas adsorption and structural tuning
Authors: Kong Xiang-Jing , Zhang Yong-Zheng , He Tao , Wu Xue-Qian , Xu Ming-Ming , Wang Si-Nan , Xie Lin-Hua , Li Jian-Rong
Published: June 2018

Structural tuning and selective gas adsorption of two interpenetrated metal–organic frameworks using a slim ethynyl-based ligand were achieved.
A predictive model for the diffusion of a highly non-ideal ternary system
Authors: Allie-Ebrahim Tariq , Russo Vincenzo , Ortona Ornella , Paduano Luigi , Tesser Riccardo , Di Serio Martino , Singh Pranav , Zhu Qingyu , Moggridge Geoff D. , D’Agostino Carmine
Published: June 2018

The Maxwell–Stefan and dynamic concentration fluctuation models were compared in predicting mutual diffusivity in non-ideal ternary mixtures. The dynamic concentration fluctuation model gives improved predictions.
Detection of sulfide ion and gaseous H2S using a series of pyridine-2,6-dicarboxamide based scaffolds
Authors: Kumar Pramod , Kumar Vijay , Pandey Saurabh , Gupta Rajeev
Published: June 2018

This work presents a series of pyridine-2,6-dicarboxamide based scaffolds with different appendages and their roles as chemosensors for the selective detection of S2− ion, as well as gaseous H2S, in primarily aqueous media.
Peptides derived from the histidine–proline rich glycoprotein bind copper ions and exhibit anti-angiogenic properties
Authors: Magrì Antonio , Grasso Giulia , Corti Federico , Finetti Federica , Greco Valentina , Santoro Anna Maria , Sciuto Sebastiano , La Mendola Diego , Morbidelli Lucia , Rizzarelli Enrico
Published: June 2018

A peptide belonging to the histidine–proline rich glycoprotein binds copper(ii), inhibiting metal angiogenic responses in endothelial cells.
Efficient visible-light-driven selective oxygen reduction to hydrogen peroxide by oxygen-enriched graphitic carbon nitride polymers
Authors: Wei Zhen , Liu Meili , Zhang Zijian , Yao Wenqing , Tan Hongwei , Zhu Yongfa
Published: June 2018

Construction of oxygen-enriched graphitic carbon nitride polymers for highly efficient and selective H2O2 production via photocatalytic O2 reduction.
Low-dose addition of silver nanoparticles stresses marine plankton communities
Authors: Tsiola Anastasia , Toncelli Claudio , Fodelianakis Stilianos , Michoud Grégoire , Bucheli Thomas D. , Gavriilidou Asimenia , Kagiorgi Margarita , Kalantzi Ioanna , Knauer Katja , Kotoulas Georgios , Mylona Kyriaki , Papadopoulou Eleftheria , Psarra Stella , Santi Ioulia , Tsapakis Manolis , Daffonchio Daniele , Pergantis Spiros A. , Pitta Paraskevi
Published: June 2018

The release of silver nanoparticles (AgNPs) is expected to rise in the near future, with possible negative effects on aquatic life and enhancement of microbial resistance against AgNPs.
Spectral signatures of proton delocalization in H+(H2O)n=1−4 ions
Authors: Dzugan Laura C. , DiRisio Ryan J. , Madison Lindsey R. , McCoy Anne B.
Published: June 2018

Vibrational couplings in protonated water clusters are described by harmonic analysis, vibrational perturbation theory (VPT2) and diffusion Monte Carlo (DMC) approaches.
The influence of aqueous solvent on the electronic structure and non-adiabatic dynamics of indole explored by liquid-jet photoelectron spectroscopy
Authors: Kumar Gaurav , Roy Anirban , McMullen Ryan S. , Kutagulla Shanmukh , Bradforth Stephen E.
Published: June 2018

Time-resolved photoelectron spectroscopy (TRPES) in a liquid micro-jet is implemented here to investigate the influence of water on the electronic structure and dynamics of indole, the chromophore of the amino acid tryptophan.
Free-radical anti-Markovnikov hydroalkylation of unactivated alkenes with simple alkanes
Authors: Tian Yunfei , Ling Anbo , Fang Ren , Tan Ren Xiang , Liu Zhong-Quan
Published: June 2018

A Cu(ii)-mediated radical anti-Markovnikov hydroalkylation of unactivated alkenes with simple alkanes via selective C(sp3)–H bond cleavage was achieved. This reaction features high site-selectivity, diverse functional group tolerance, and scalability.
Surface acoustic wave diffraction driven mechanisms in microfluidic systems
Authors: Fakhfouri Armaghan , Devendran Citsabehsan , Albrecht Thomas , Collins David J. , Winkler Andreas , Schmidt Hagen , Neild Adrian
Published: June 2018

We present five distinct mechanisms arising from the incidence of a finite-width surface acoustic waves (SAW) beam propagating into a quiescent fluid.
Negatively charged boron nitride nanosheets as a potential metal-free electrocatalyst for the oxygen reduction reaction: a computational study
Authors: Wen Xin , Wang Yongcheng , Zhao Jingxiang
Published: June 2018

The negative charged boron nitride nanosheet is a novel metal free catalysts for the oxygen reduction reaction.
Aggregation-induced ratiometric emission and mechanochromic luminescence in a pyrene-benzohydrazonate conjugate
Authors: Li Yao , Huang Wei , Yong Juan , Huang Shuaidan , Li Yujie , Liu Yang , Wu Dayu
Published: June 2018

A structure tunable pyrene benzohydrazonate-based molecular platform exhibits a drastic aggregation-induced color change and a high solid-state quantum yield.
Acidic ionic liquids: an alternative to HF for {001} reactive facet controlled synthesis of anatase titania
Authors: Sandhu Sofia , Shahi Satwant Kaur , Singh Vasundhara
Published: June 2018

A HF free method for the controlled synthesis of nanosized TiO2 with a higher percentage of {001} reactive facets.
Catalytic activity of corrole complexes with post-transition elements for the oxidation of carbon monoxide: a first-principles study
Authors: Mohajeri Afshan , Hassani Nasim
Published: June 2018

Our theoretical investigation shows that the aluminum and gallium complexes of corrole can be considered as potential high-performance catalysts for the oxidation of CO.
A multi-signal fluorescent probe for the discrimination of cysteine/homocysteine and glutathione and application in living cells and zebrafish
Authors: Xu Gaoping , Tang Yonghe , Lin Weiying
Published: June 2018

A multi-signal fluorescent probe for the discrimination of cysteine/homocysteine and glutathione was engineered in living cells by one-photon and two-photon modes and zebrafish by one-photon modes.
Mixed polymeric micelles as a multifunctional visual thermosensor for the rapid analysis of mixed metal ions with Al3+ and Fe3+
Authors: Han Juan , Cai Yunfeng , Wang Yun , Dai Xiaohui , Wang Lei , Li Chunmei , An Baodong , Ni Liang
Published: June 2018

A novel type of responsive mixed double hydrophilic block copolymer (DHBC)-based multifunctional visual thermosensor for the detection of Al3+ and Fe3+ was designed and synthesized based on reversible addition fragmentation chain transfer (RAFT) polymerization.
Efficient synthetic procedure to new 2-imino-1,3-thiazolines and thiazolidin-4-ones promoted by acetonitrile electrogenerated base
Authors: Haouas Beya , Sbei Najwa , Ayari Hana , Benkhoud M. Lamine , Batanero Belen
Published: June 2018

Regioselective sulfur–carbon bond formation from disubstituted thioureas and 1,2-dielectrophiles.
Immuno-modified superparamagnetic nanoparticles via host–guest interactions for high-purity capture and mild release of exosomes
Authors: Cai Shuang , Luo Bin , Jiang Peipei , Zhou Xiaoxi , Lan Fang , Yi Qiangying , Wu Yao
Published: June 2018

Host–guest interactions involved immunoaffinity superparamagnetic nanoparticles for fast, high-efficiency and high-purity exosome isolation and elution.
A 1,2,3-triazolyl based conjugated microporous polymer for sensitive detection of p-nitroaniline and Au nanoparticle immobilization
Authors: Wei Feng , Cai Xinyi , Nie Junqi , Wang Feiyi , Lu Cuifen , Yang Guichun , Chen Zuxing , Ma Chao , Zhang Yuexing
Published: June 2018

A 1,2,3-triazolyl based fluorescent CMP was used as an excellent chemosensor for p-nitroaniline detection and a support for Au catalyst deposition.
Hydrothermally grown CdS nanoparticles for photodegradation of anionic azo dyes under UV-visible light irradiation
Authors: Senasu Teeradech , Hemavibool Khuanjit , Nanan Suwat
Published: June 2018

A CdS photocatalyst was synthesized successfully at low temperature via a catalyst-free hydrothermal technique which is simple, green and also easily controlled.
Metagenomic discovery of a novel transaminase for valorization of monoaromatic compounds
Authors: Pawar Sandip V. , Hallam Steven J. , Yadav Vikramaditya G.
Published: June 2018

We have deployed functional metagenomics toward the identification of a novel transaminase that can selectively functionalize lignin-derived monoaromatics to produce value-added feedstocks for pharmaceutical synthesis.
Strain and screening effects on field emission properties of armchair graphene nanoribbon arrays: a first-principles study
Authors: Hu Han , Loh Siow Mean , Leung Tsan-Chuen , Lin Ming-Chieh
Published: June 2018

The field screening effect on the field-emission properties of armchair graphene nanoribbons (AGNRs) under strain has been studied using first-principles calculations with local density approximation (LDA).
Dopamine incorporating forward osmosis membranes with enhanced selectivity and antifouling properties
Authors: Wang Yi , Fang Zhendong , Zhao Shuaifei , Ng Derrick , Zhang Juan , Xie Zongli
Published: June 2018

Incorporation of dopamine enhanced selectivity and antifouling properties of novel TFC polyamide FO membranes.
Accessing new 2D semiconductors with optical band gap: synthesis of iron-intercalated titanium diselenide thin films via LPCVD
Authors: Sanchez-Perez Clara , Knapp Caroline E. , Colman Ross H. , Sotelo-Vazquez Carlos , Oilunkaniemi Raija , Laitinen Risto S. , Carmalt Claire J.
Published: June 2018

Fe-doped TiSe2 thin-films were synthesized via low pressure chemical vapor deposition (LPCVD) of a single source precursor: [Fe(η5-C5H4Se)2Ti(η5-C5H5)2]2 (1).
Molecular modelling of supramolecular one dimensional polymers
Authors: Korlepara Divya B. , Balasubramanian S.
Published: June 2018

Hierarchical computational modelling approaches for the study of supramolecular polymers is reviewed.
Development and evaluation of pymetrozine controlled-release formulation to control paddy planthopper
Authors: Xu Wei-Ming , Zhang Ming , Wei Kun , Chen Yan , Liu Qin , Xue Wei , Jin Lin-Hong , He Ming , Chen Zuo , Zeng Song
Published: June 2018

Continuous outbreaks of rice planthoppers in rice-growing regions in China indicates the importance of redesigning several planthopper management programs.
One-pot synthesis of enhanced fluorescent copper nanoclusters encapsulated in metal–organic frameworks
Authors: Han Bingyan , Hu Xixi , Yu Mingbo , Peng Tingting , Li Ying , He Gaohong
Published: June 2018

The encapsulation of Cu nanoclusters (Cu NCs) in metal–organic frameworks (MOFs) would improve the properties of Cu NCs.
Droplet-train induced spatiotemporal swelling regimes in elastomers
Authors: Phadnis Akshay , Manning Kenneth C. , Sanders Ian , Burgin Timothy P. , Rykaczewski Konrad
Published: June 2018

In this work, we perform a combined experimental and numerical analysis of elastomer swelling dynamics upon impingement of a train of solvent droplets.
Thermomechanical properties of monodomain nematic main-chain liquid crystal elastomers
Authors: Merkel Daniel R. , Traugutt Nicholas A. , Visvanathan Rayshan , Yakacki Christopher M. , Frick Carl P.
Published: June 2018

Actuation temperature was controlled without influencing total actuation performance in liquid crystal elastomers fabricated by a two-stage reaction scheme.
Graphene-supported 2D transition metal oxide heterostructures
Authors: Azadmanjiri Jalal , Srivastava Vijay K. , Kumar Parshant , Wang James , Yu Aimin
Published: June 2018

New emerging graphene-supported 2D transition metal oxide heterostructures are attracting interest for high-efficiency energy storage and energy conversion devices.
Chemical-assisted hydrogen electrocatalytic evolution reaction (CAHER)
Authors: Chen Lisong , Shi Jianlin
Published: June 2018

The most recent progress in the chemical-assisted hydrogen electrocatalytic evolution reaction (CAHER) is introduced in this mini-review.
A new 3D Dirac nodal-line semi-metallic graphene monolith for lithium ion battery anode materials
Authors: Liu Jie , Li Xiaoyin , Wang Qian , Kawazoe Yoshiyuki , Jena Puru
Published: June 2018

Design of a new 3D Dirac nodal-line semi-metallic graphene monolith with potential for a high performance lithium ion battery anode material.
Facile regrowth of Mg-Fe2O3/P-Fe2O3 homojunction photoelectrode for efficient solar water oxidation
Authors: Li Feng , Li Jing , Li Fengwang , Gao Lili , Long Xuefeng , Hu Yiping , Wang Chenglong , Wei Shenqi , Jin Jun , Ma Jiantai
Published: June 2018

In this article, we applied a facile regrowth strategy to prepare Mg-Fe2O3/P-Fe2O3 NRs photoanode with homojunction structure, which shown high PEC water oxidation efficiency. Experimental and theoretical results reveal that the origin of the superior PEC performance is dependent on P-doping and Mg-Fe2O3 coating.
Recent progress in silver nanowire based flexible/wearable optoelectronics
Authors: Kwon Jinhyeong , Suh Young D. , Lee Jinhwan , Lee Phillip , Han Seungyong , Hong Sukjoon , Yeo Junyeob , Lee Habeom , Ko Seung Hwan
Published: June 2018

A summary of the recent and potential future developments in silver nanowire based flexible/wearable optoelectronic applications is presented.
NIR–NIR photon avalanche based luminescent thermometry with Nd3+doped nanoparticles
Authors: Marciniak Lukasz , Bednarkiewicz Artur , Elzbieciak Karolina
Published: June 2018

Here, we show an unprecedented approach to luminescentTsensing, which relies on highly temperature dependent nonresonant 1064 nm NIR photoexcitation and a 890 nm anti-Stokes avalanche-like NIR emission from Nd3+doped nanoparticles.
The chromatin nuclear protein NUPR1L is intrinsically disordered and binds to the same proteins as its paralogue
Authors: Neira José L. , López María Belén , Sevilla Paz , Rizzuti Bruno , Cámara-Artigas Ana , Vidal Miguel , Iovanna Juan L.
Published: June 2018

NUPR1 is a protumoral multifunctional intrinsically disordered protein (IDP), which is activated during the acute phases of pancreatitis. It interacts with other IDPs such as prothymosin α, as well as with folded proteins such as the C-terminal region of RING1-B (C-RING1B) of the Polycomb complex; in all those interactions, residues around Ala33 and Thr68 (the ‘hot-spot’ region) of NUPR1 intervene. Its paralogue, NUPR1L, is also expressed in response to DNA damage, it is p53-regulated, and its expression down-regulates that of the NUPR1 gene. In this work, we characterized the conformational preferences of isolated NUPR1L and its possible interactions with the same molecular partners of NUPR1. Our results show that NUPR1L was an oligomeric IDP from pH 2.0 to 12.0, as judged by steady-state fluorescence, circular dichroism (CD), dynamic light scattering, 1D 1H-NMR (nuclear magnetic resonance), and as indicated by structural modelling. However, in contrast with NUPR1, there was evidence of local helical- or turn-like structures; these structures were not rigid, as judged by the lack of sigmoidal behaviour in the chemical and thermal denaturation curves obtained by CD and fluorescence. Interestingly enough, NUPR1L interacted with prothymosin α and C-RING1B, and with a similar affinity to that of NUPR1 (in the low micromolar range). Moreover, NUPR1L hetero-associated with NUPR1 with an affinity of 0.4 µM and interacted with the ‘hot-spot’ region of NUPR1. Thus, we suggest that the regulation of NUPR1 gene by NUPR1L does not only happen at the DNA level, but it could also involve direct interactions with NUPR1 natural partners.
Optimal operation management of a regional network of microgrids based on chance‐constrained model predictive control
Authors: Bazmohammadi Najmeh , Tahsiri Ahmadreza , Anvari‐Moghaddam Amjad , Guerrero Josep M.
Published: June 2018

A regional network of microgrids includes a cluster of microgrids located in a neighbourhood area connecting together through power lines. In this study, the problem of operation management of networked‐microgrids is considered. The main goal is to develop an efficient strategy to control local operation of each microgrid including the amount of energy to be requested from the main grid and the optimal charging/discharging patterns of batteries along with the transferred power among microgrids considering system's technical constraints. Accounting for system uncertainty due to the presence of renewable energy sources and variability of loads, the problem is formulated in the framework of chance‐constrained model predictive control. Moreover, the Monte Carlo algorithm is adopted to generate discrete random scenarios to evaluate the solutions. Simulation studies have been exemplarily carried out in order to show the effectiveness of the proposed approach.
Eigencurves for linear elliptic equations
Authors: Rivas Mauricio A. , Robinson Stephen B.
Published: June 2018

This paper provides results forvariational eigencurvesassociated with self-adjoint linear elliptic boundary value problems. The elliptic problems are treated as a general two-parameter eigenproblem for a triple (a,b,m) of continuous symmetric bilinear forms on a real separable Hilbert spaceV.Geometric characterizationsof eigencurves associated with (a,b,m) are obtained and are based on their variational characterizations described here. Continuity, differentiability, as well as asymptotic, results for these eigencurves are proved. Finally, two-parameter Robin–Steklov eigenproblems are treated to illustrate the theory.
Return to Work und Stay at Work – Die Frage nach einem gelingenden betrieblichen Eingliederungsmanagement
Authors: Ohlbrecht Heike , Detka Carsten , Kuczyk Susanne , Lange Bianca
Published: June 2018

Ziel der Studie Im Mittelpunkt der Studie steht die Frage danach, wie die Ausgestaltung des betrieblichen Eingliederungsmanagements (BEM), insbesondere in kleineren und mittleren Unternehmen (KMU), optimiert werden kann und wie bisherige Erfahrungen mit dem BEM zur Entwicklung früher ansetzender präventiver Maßnahmen zur Sicherung der Beschäftigungsfähigkeit genutzt werden können.

Methodik Die Studie folgt einem multiperspektivischen, qualitativen Forschungsdesign. Im Fokus stand dabei die Erhebung von 40 retrospektiven Interviews mit Arbeitnehmenden, die unterschiedliche Varianten des BEM durchlaufen haben. Zudem wurden betriebliche sowie überbetriebliche Akteure durch Expertenbefragungen in den Blick genommen. Die Auswertung der Interviews folgte der Heuristik der Fallrekonstruktion und der Forschungsstrategie der Grounded Theory.

Ergebnisse Es lassen sich verschiedene Einflussfaktoren für die Ausgestaltung eines betrieblichen Eingliederungsmanagements identifizieren – die biografisch verankerten Haltungen der Arbeitgebenden und Arbeitnehmenden, die Unternehmenskultur sowie (betriebsspezifische) strukturelle Faktoren, die zu Gelingensbedingungen und Hemmfaktoren für BEM-Prozesse in KMU werden können. Ebenso zeigen sich Dilemmata, die BEM-Prozesse behindern können. BEM-Prozesse können auch Wirkungen entfalten, die über die BEM-Ziele im engeren Sinne hinausgehen.

Schlussfolgerung Gelingen können die Wiedereingliederung und der Erhalt der Beschäftigungsfähigkeit der Arbeitnehmenden v. a. dann, wenn eine auf Vertrauen beruhende Betriebskultur der Achtsamkeit, Wertschätzung und Offenheit besteht. Dies hängt insbesondere von den Haltungen aller Beteiligten ab. Doch auch in einer solchen Betriebskultur haben Dilemmata und Konfliktpotenziale einen Einfluss auf das Gelingen des BEM-Prozesses. Jedes Unternehmen benötigt zudem interne und/oder externe Akteure, die über ausreichend Wissen und Kompetenzen zur Durchführung eines BEMs verfügen.
High-intensity Interval Training in Different Exercise Modes: Lessons from Time to Exhaustion
Authors: Sousa Ana , Fernandes Ricardo , Boas Joao , Figueiredo Pedro
Published: June 2018

To provide information for high-intensity interval training (HIIT) load, we compared the temporal variables of VO2 response at, and after, a time sustained at the exercise intensity corresponding to VO2max (Tlim) in different exercise modes. Forty-five trained male swimmers (11), rowers (13), runners (10) and cyclists (11) completed an incremental protocol to determine the velocity (vVO2max) or power (wVO2max) at VO2max and a square wave exercise from rest to 100% of vVO2max/wVO2max. The temporal variables of VO2 response were examined using a breath-by-breath gas analyzer. VO2 responses were not different between exercise modes, except for the percentage of VO2max at 50% of Tlim, which was ~6% higher in rowing compared to cycling (97.70±2.90 vs 92.40±5.69%, p=0.013). During the recovery period, both swimmers and rowers evidenced higher percentages of VO2max compared to cyclists at 30 s (65.1±10.4 and 65.7±5.6 vs 52.7±5.6%) and 60 s (41.7±10.8 and 38.4±5.4 vs 30.4±1.8%) time periods, all for p<0.01. Furthermore, swimmers presented higher time values to reach 50% VO2max compared to runners and cyclists (51.1±15.6 vs 38.1±6.7 and 33.8±4.7%; p<0.001). When training at 100% of VO2max intensity, fixed intervals for HIIT could be set freely. However, recovery periods based on time or intensity are exercise-mode dependent.
The Effect of Increasing Jump Steps on Stance Leg Joint Kinetics in Bounding
Authors: Kariyama Yasushi , Hobara Hiroaki , Zushi Koji
Published: June 2018

Jump distance per step in bounding exercises from the standing position increases with increasing number of steps. We examined the hypothesis that the joint kinetic variables of the stance leg would also increase accordingly. Eleven male athletes (sprinters and jumpers) performed bounding exercise, starting from the double-leg standing posture, and covered the longest distance possible by performing a series of seven forward alternating single-leg jumps. Kinematic and kinetic data were calculated using the data by a motion capture system and force platforms. Hip extension joint work were decreased at third step (1st: 1.07±0.22, 3rd: 0.45±0.15, 5th: 0.47±0.14 J•kg−1; partial η2: 0.86), and hip abduction joint power were increased (1st: 7.53±3.29, 3rd: 13.50±4.44, 5th: 21.37±9.93 W•kg−1; partial η2: 0.58); the knee extension joint power were increased until the third step (1st: 14.43±4.94, 3rd: 17.13±3.59, 5th: 14.28±2.86 W•kg−1; partial η2: 0.29), and ankle plantar flexion joint power increased (1st: 34.14±5.33, 3rd: 37.46±4.45, 5th: 40.11±5.66 W•kg−1; partial η2: 0.53). These results contrast with our hypothesis, and indicate that increasing the jump distance during bounding exercises is not necessarily accompanied by increases in joint kinetics of stance leg. Moreover, changes in joint kinetics vary at different joints and anatomical axes.
Safety and Toxicology of Magnolol and Honokiol
Authors: Sarrica Andrea , Kirika Natalja , Romeo Margherita , Salmona Mario , Diomede Luisa
Published: June 2018

Magnolia officinalis and Magnolia obovata bark extracts have been used for thousands of years in Chinese and Japanese traditional medicines and are still widely employed as herbal preparations for their sedative, antioxidant, anti-inflammatory, antibiotic, and antispastic effects. Neolignans, particularly magnolol and honokiol, are the main substances responsible for the beneficial properties of the magnolia bark extract (MBE). The content of magnolol and honokiol in MBE depends on different factors, including the Magnolia plant species, the area of origin, the part of the plant employed, and the method used to prepare the extract. The biological and pharmacological activities of magnolol and honokiol have been extensively investigated. Here we review the safety and toxicological properties of magnolol and honokiol as pure substances or as components of concentrated MBE, including the potential side-effects in humans after oral intake. In vitro and in vivo genotoxicity studies indicated that concentrated MBE has no mutagenic and genotoxic potential, while a subchronic study performed according to OECD (Organisation for Economic Co-operation and Development) guidelines established a no adverse effect level for concentrated MBE > 240 mg/kg b.w/d. Similar to other dietary polyphenols, magnolol and honokiol are subject to glucuronidation, and despite a relatively quick clearance, an interaction with pharmaceutical active principles or other herbal constituents cannot be excluded. However, intervention trials employing concentrated MBE for up to 1 y did not report adverse effects. In conclusion, over the recent years different food safety authorities evaluated magnolol and honokiol and considered them safe.
Transition-Metal-Free Enantioselective Reactions of Organo­magnesium Reagents Mediated by Chiral Ligands
Authors: Boussonnière Anne , Castanet Anne-Sophie , Guyon Hélène
Published: June 2018

Organomagnesium reagents are among the most important reagents in organic chemistry because of their great utility in forming carbon–carbon bonds. Although most enantioselective reactions using these organometallics involve transmetalation, the past decade has witnessed impressive advances in direct chiral-ligand-mediated reactions of organomagnesiums­. This short review presents an overview of these achievements in enantioselective nucleophilic additions and substitutions.

1 Introduction

2 Enantioselective Nucleophilic Additions

2.1 Addition to C=O Bonds

2.2 Addition to C=N Bonds

2.3 Addition to C=C Bonds

3 Enantioselective Substitution Reactions

3.1 Sulfoxide–Magnesium Exchange

3.2 Desymmetrization via Anhydride Opening

3.3 Asymmetric Allylic Alkylation (AAA)

4 Conclusion
Dissymmetric Bay-Functionalized Perylenediimides
Authors: Singh Prabhpreet , Kumar Kapil , Bhargava Gaurav , Kumar Subodh
Published: June 2018

We report the synthesis of perylenediimide (PDI)-based ­donor–acceptor hybrids through dissymmetric bay functionalization of PDIs. The dissymmetric bay-functionalized di- and trisubstituted PDIs were characterized by using one- and two-dimensional NMR spectroscopy. Density functional theory calculations revealed (i) an energy gap between the HOMO and LUMO in the range 2.14–2.34 eV, beneficial for charge-transfer properties; and (ii) a twist angle between the two naphthalene units in the range 17–26°, which might be beneficial for disruption of co-facial stacking of the PDI.
6 and 14 Hz Positive Spikes on Scalp Electroencephalogram
Authors: Sanariya Kalpesh , Garg Arun , More Aniruddha , Bansal Atma
Published: June 2018

Benign epileptiform variants (BEVs) are often noted in routine electroencephalogram (EEG) monitoring and are sometimes misinterpreted as epileptiform discharges. Six and 14 Hz positive spikes are one of such BEVs seen especially in children. However, these variants can also be seen in intensive care unit EEG recordings. Here, we have reviewed the history and electrical details of these 6 and 14 Hz variants with their clinical significance.
Febrile Neutropenia following Parvovirus B19 Infection and Cross Anti-Kell Reaction to E. Coli in Pregnancy
Authors: Brandão Pedro , Freixo Marília , Soares Elisa , Estevinho Catarina , Carvalho Ana Sofia Portela , Melo Anabela
Published: June 2018

Parvovirus B19 has tropism for red line blood cells, causing immune hydrops during pregnancy. A positive anti-Kell Coombs reaction usually happens during pregnancy when there is production of antibodies that target Kell antigens, but cross reactions to other antigens may occur. A 24-year-old Gypsy primigravida, 0 Rhesus positive, presented with persistent isolated hyperthermia for 2 weeks and a positive indirect Coombs test result with anti-Kell antibodies at routine tests. She had a 19-week live fetus. The blood tests revealed bicytopenia with iron deficiency anemia, leucopoenia with neutropenia, and elevated C-reactive protein. She was medicated with imipenem, and had a slow clinical recovery. Blood, urine and sputum samples were taken to perform cultures and to exclude other systemic infections. Escherichia coli was isolated in the urine, which most probably caused a transient cross anti-Kell reaction. Haemophilus influenza in the sputum and seroconversion to parvovirus B19 was confirmed, causing unusual deficits in the white cells, culminating in febrile neutropenia. Despite the patient's lack of compliance to the medical care, both maternal and fetal/neonatal outcomes were good. This a rare case report of 2 rare phenomena, a cross anti-Kell reaction to E. coli and parvovirus B19 infection with tropism for white cells causing febrile neutropenia, both events occurring simultaneously during pregnancy.
Design and Testing of a Smartphone Application for Real-Time Self-Tracking Diabetes Self-Management Behaviors
Authors: Groat Danielle , Soni Hiral , Grando Maria , Thompson Bithika , Kaufman David , Cook Curtiss
Published: June 2018

Background Type 1 diabetes (T1D) care requires multiple daily self-management behaviors (SMBs). Preliminary studies on SMBs rely mainly on self-reported survey and interview data. There is little information on adult T1D SMBs, along with corresponding compensation techniques (CTs), gathered in real-time.

Objective The article aims to use a patient-centered approach to design iDECIDE, a smartphone application that gathers daily diabetes SMBs and CTs related to meal and alcohol intake and exercise in real-time, and contrast patients' actual behaviors against those self-reported with the app.

Methods Two usability studies were used to improve iDECIDE's functionality. These were followed by a 30-day pilot test of the redesigned app. A survey designed to capture diabetes SMBs and CTs was administered prior to the 30-day pilot test. Survey results were compared against iDECIDE logs.

Results Usability studies revealed that participants desired advanced features for self-tracking meals and alcohol intake. Thirteen participants recorded over 1,200 CTs for carbohydrates during the 30-day study. Participants also recorded 76 alcohol and 166 exercise CTs. Comparisons of survey responses and iDECIDE logs showed mean% (standard deviation) concordance of 77% (25) for SMBs related to meals, where concordance of 100% indicates a perfect match. There was low concordance of 35% (35) and 46% (41) for alcohol and exercise events, respectively.

Conclusion The high variability found in SMBs and CTs highlights the need for real-time diabetes self-tracking mechanisms to better understand SMBs and CTs. Future work will use the developed app to collect SMBs and CTs and identify patient-specific diabetes adherence barriers that could be addressed with individualized education interventions.