bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of some essential oils on pathogenes that cause eczema
Authors: Karacam Meryem , Kaya Durmus Alpaslan
Published: December 2020

In this study, the antimicrobial activity of essential oils obtained from Thymbra spicata L., Lavandula angustifolia Mill. and Myrtus communis L. on the pathogens causing eczema Staphylococcus aureus (ATCC 29213), Staphylococcus epidermidis (ATCC 12228), Escheria coli (ATCC 25922), Acinetobacter baumannii (ATCC 43498), Pseudomonas aeruginosa (ATCC 27853) ve Candida albicans (ATCC 90028) were investigated. The MIC and MBC values of the essential oils used in the study against the pathogens causing eczema were determined. As a result of the results obtained, antimicrobial activity of plant essential oils used in the study on test microorganisms was determined. Among the essential oils, it was found that the most effective essential oil was thyme followed by the lavender.
The variation of essential oil and carvacrol contents of native grown Thymbra Spicata var. Spicata L.
Authors: Mavi Kazim , Kaya Durmus Alpaslan , Turkmen Musa , Ayanoglu Filiz
Published: December 2020

In the study, it is aimed to create breeding lines of thyme (Thymbra spicata L.), which is important both culturally and economically, by selecting a single plant among the plants grown in different regions in Hatay. For this purpose, a genetic pool was created for Thymbra spicata L. plant in the plant samples taken from the locations where the plants are densely grown, and these plants were examined in terms of leaf characteristics, number of oil glands per unit area, oil gud size and essential oil components. Plants were propagated and preserved with cuttings taken from these single plants. In this study, which includes the pre-selection stage, 213 plants from 68 different locations were determined in the province of Hatay. The essential oil ratios of the plants varied between 0.70% and 3.90% and showed a wide variation. The rate of carvacrol, which is the main component of the essential oil of the thyme plant, was between 28.12% and 78.48%. Plants with code number Z14, Z3, Z25, Z38, Z77, Z104, Z35 and Z43 with an essential oil ratio of 3.5% and above and plants with code number Z167, Z165 and Z64 with a high carvacrol ratio were selected to be used in future breeding studies.
Analysis of the bakery industry strategic groups in Romania
Authors: Deselnicu Dana Corina , Bulboaca Mihaela-Ramona , Dumitriu Dan , Alexandrescu Laurentia
Published: December 2020

The bakery industry is one with as many challenges as any other FMCG (Fast Moving Consumer Goods) industry. In this sense, at the basis of each strategic decision, in order to improve competitiveness, on a constantly moving market, is the knowledge of competitors, the actions taken by them but also the innovation processes in which they are engaged. This paper aims to analyze the strategic groups formed in the bakery industry in Romania in terms of competitiveness. The paper begins with the analysis of the bakery industry, based on the parameters identified in the literature, continues with the investigation of strategic groups of the analyzed industry, according to the number of products sold and the geographical coverage of its players. Some of the paper results include a series of possible solutions and decisions that each company could apply, considering this segmentation. Analyzing the strategic groups of the bakery industry in Romania using current data and innovative analysis methods. The results of the study revealed a map of the strategic groups formed in the bakery industry, useful for companies in order to establish future strategic directions for maintaining or increasing their competitive position in the market in which they operate.
Developing an E-Business system to improve the downstream pharmaceutical supply chain (A study on the Egyptian market)
Authors: Haddad Sandra
Published: December 2020

Pharmaceutical products are considered sensitive products that require a well-managed distribution channel as they impact human lives. The aim of this research is to investigate the applicability of improving the downstream of the pharmaceutical supply chain (distribution channel) in Egypt through developing an E-business system. The study has adopted a deductive approach. Qualitative and quantitative methodologies were followed respectively. Qualitative in-depth interviews were conducted to get a better understanding of the situation in Egypt followed by a structured survey to test and verify the significance and the relation of the extracted variables using statistical tools. This resulted in highlighting significant variables impacting the relationship between pharmaceutical retailers (pharmacies) and consumers and the applicability of introducing an e-business retailing application that improves downstream chain performance by facilitating transactions i.e. easily locating the required medicine, matching consumers and retailers and spotting the inventory level in the distribution channel for better management solutions.
Comparative analysis of carbon dioxide methanation technologies for low carbon society development
Authors: Lazaroiu Gheorghe , Ciupageanu Dana-Alexandra , Mihaescu Lucian , Grigoriu Rodica-Manuela
Published: December 2020

Conversion technologies able to transform renewable energy sources (RES) based electricity in gaseous fuels, which can be stored over long timeframes, represent a key focus point considering the low carbon society development. Thus, Power-to-Gas technologies emerge as a viable solution to mitigate the variability of RES power generation, enabling spatial and temporal balancing of production vs. demand mismatches. An additional benefit in this context is brought by the decarbonization facilities, employing polluting carbon dioxide (CO2) emissions and RES-based electricity to produce synthetic natural gas with high methane (CH4) concentration. The fuel obtained can be stored or injected in the gas distribution infrastructure, becoming a clean energy vector. This paper investigates the functional parameters of such technologies, aiming to comparatively analyze their suitability for further integration in hybrid and ecofriendly energy systems. Given the stability of CO2 molecule, a catalyst must be used to overcome the methanation reaction kinetics limitations. Therefore, the required conditions (in terms of pressure and temperature) for CO2 methanation reaction unfolding are analyzed first. Further, CO2 conversion rate and CH4 selectivity are investigated in order to provide a detailed comparison of available technologies in the field, addressing moreover the particularities of catalyst preparation processes. It is found that Nickel (Ni) based catalysts are performing well, achieving good performances even at atmospheric pressure and low temperatures. It is remarkable that, within a [300,500]℃ temperature range, Ni-based catalysts enable a CO2 conversion rate over 78% with a CH4 selectivity of up to 100%. Last, integration perspectives and benefits are discussed, highlighting the crucial importance of the results presented in this paper.
Innovative tool for the circular design of technical textiles
Authors: Sarbu Teodor , Dorogan Angela , Grosu Cristina , Stroe Cristina Elena
Published: December 2020

Our planet is going through political, economic, social and ecological crisis, which are constantly feeding each other. Human activities driven by a rapidly growing global population, unsustainable economic growth, technological innovations, but also inappropriate production practices and consumption models- create increasing pressures on ecosystems and natural resources. Neither the social nor the ecological crisis can't be overpassed without changing the way of our economic system works and which involves the manner how innovative transformations take place. In this context, it is mandatory to use design as a strategy consist of people to understand the basic principles of design: user orientation, empathy, mental and physical process, future orientation, visual approach, co-creativity, interconnection of complex systems, continuous testing and iteration. The circular design is an innovative tool for implementing the circular economy whose main purpose is: "to connect all material flows, integrating them in a circular process, which ensures efficient consumption of resources and minimizes the amount of resulting waste". The paper presents a practical example of using an interactive map, owned by Delft University of Technology (Netherlands), applied as a technical analysis tool, in order to determine the reuse potential of a technical product components, specifically a laptop bag for transporting personal IT equipment.
Designing and obtaining wood waste and chloroprene rubber-based composites
Authors: Georgescu Mihai , Sonmez Maria , Alexandrescu Laurentia , Nituica Mihaela , Stelescu Maria Daniela , Gurau Dana
Published: December 2020

The aim of this paper is to obtain and study the properties of wood waste reinforced elastomer composites with various fibre contents (10-50 wt%). The composite is based on chloroprene rubber, and added post-consumer recycled wood particles, with dimensions of 500 nm eco-reinforcing material, and active fillers, plasticizers, vulcanizing agents, antioxidants. In order to enhance the compatibility and their level of interaction, the wood waste was finely ground (cryogenic mill) and functionalized with potassium oleate. Wood waste acts as a filling material which leads to the biodegradability of the composite and the decrease in density. Tensile, tear strength, elasticity, hardness, abrasion resistance, melt flow index and morphological study (FT-IR) of those composites were examined in order to determine the viability in various applications domains.
Serum Copeptin as the Predictor for Acute Heart Failure Complication of Acute Myocardial Infarction in Patients with ST-Segment Elevation
Authors: Supomo Ardi Putranto Ari , Suparyatmo JB. , Ariningrum Dian
Published: December 2020

Acute Myocardial Infarction (AMI) is necrotic cardiac muscle cells due to unstable ischemic syndrome. Therapy monitoring is needed because various complications may occur (Heart Failure/HF). ST-Segment Elevation Myocardial Infarction (STEMI) can develop to Acute Heart Failure (AHF) due to myocardial dysfunction, transmural heart disease, pathological cardiac remodeling. Copeptin is an antidiuretic hormone which increases in the cardiac event. It can be used as a predictor of a further cardiac event. This study aimed to determine the role of serum copeptin level as a predictor of AHF complication in STEMI patients. A prospective cohort study was performed in 85 adult STEMI patients admitted to The Clinical Pathology Installation of Dr. Moewardi Hospital, Surakarta. Data with normal and abnormal distribution were presented in mean±Standard Deviation (SD) and median (min-max), respectively. Statistical analysis was performed using Kolmogorov-Smirnov, bivariate, and multivariate analysis for RR with Confidence Interval (CI) of 95% and p < 0.05 was considered significant. The copeptin cut-off point was determined using the ROC curve. Bivariate and multivariate analysis showed a higher copeptin level in STEMI patients with AHF compared to that of non-AHF (RR=5.172, CI 95% 1.795-14.902, p=0.002 and RR=1.889, CI 95% 1.156-3.086, p=0.001; respectively). The STEMI patients with an elevated level of copeptin showed an increased risk of AHF (STEMI with elevated copeptin level vs STEMI with normal copeptin level; 28.74% vs. 88.91%). Copeptin level is significantly related to AHF complication in STEMI patient, the higher level of copeptin led to the higher the risk of AHF.
The Association of Syphilis Infection and Other Risk Factors with Immunity of Patients with HIV on Anti-Retroviral Therapy
Authors: Siong Pik , Sidharta B. Rina A. , Kurniati Amiroh
Published: December 2020

Syphilis infection, age, gender, sexual behaviour, length of HIV infection and length of ARV treatment are suspected to be associated with amount of cluster of differentiation 4 (CD4+)T-cells (CD4+ T-cell) and CD4+ T-cells: CD8+ T-cells ratio (CD4:CD8) of HIV patients on ARV. However, the evidence remains lacking. The aim of this cross-sectional study on April 24th to June 20th, 2019 was to determine the association of syphilis infection and other risk factors (age, gender, sexual behavior, length of HIV infection and ARV treatment) with the immunity of patients with HIV on ARV based on T CD4+ and CD4:CD8, and got factors those have an influence to T CD4+ and CD4:CD8. Seventy-four subjects with age â‰¥18 years old with HIV on ARV from Voluntary Counselling Test (VCT) Outpatients of Dr. Moewardi General Hospital in Surakarta (DMGHS) had been examined for syphilis, T CD4+ count and CD4:CD8 in Clinical Pathology Laboratory of DMGHS. Other data had been completed from the anamnesis and VCT data system. All data had been processed with SPSS version 21. Multivariate logistic regression following bivariate analysis of the Chi-Square test was used for categorical variables. Bivariate analysis showed a significant association between age, length of HIV infection and length of ARV treatment to T CD4+ count and significant association between sexual behavior, length of HIV infection, and length of ARV treatment to CD4:CD8 (p<0.05). Multivariate analysis showed that the prevalence of CD4â‰¤500 was higher in male Prevalence Ratio (PR)=3.256; p=0.038) than that of female and subjects aged >42 y.o. compared to those aged >18-42 y.o. (PR=3.451; p=0.047). The PR of CD4:CD8<0.3 in anal sex (PR=3.575; p=0.049) was higher than that of vaginal sex. The PR of CD4â‰¤500 (PR=0.271; p=0.020) and CD4:CD8<0.3 (PR=0.125; p=0.001) in subjects with length of HIV >5 years were lower than those in HIV 0-5 years. Age, gender, and length of HIV potentially affect the probability of T CD4+â‰¤500. Sexual behavior and length of HIV potentially affect the probability of CD4:CD8<0.3. Both CD4 and CD4:CD8 ratio must be tested at baseline and follow-up.
Diagnostic Test of Serum Pregnancy-Associated Plasma Protein-A Level as Biomarker for Early Diagnosis of Acute Myocardial Infarction
Authors: Astuti Novida Dwi , Suparyatmo JB. , Kurniati Amiroh
Published: December 2020

Acute coronary syndrome is the primary cause of death from heart disease worldwide. This syndrome is caused by ruptured/eroded coronary atherosclerotic plaque, resulting in partial/total occlusion of thrombosis. It is necessary to find novel cardiac biomarkers for the identification of plaque progression before ischemic and myocardial necrosis events. Pregnancy Associated Plasma Protein-A (PAPP-A) is an atherosclerotic mediator proven to be a biomarker for plaque instability. This study aimed to determine the performance of serum PAPP-A as a biomarker for the early diagnosis of AMI. This research was an analytical observational study with a cross-sectional approach. Serum PAPP-A was measured using enzyme-linked immunosorbent assay in 82 new patients. They had ACS and were admitted to the emergency installation of Dr. Moewardi Hospital in Surakarta in August-September 2019. The subjects were grouped into the AMI group (NSTEMI and STEMI) consisting of 49(59.8%) subjects and non-AMI (UAP) group composed of 33(40.2%) subjects based on ACS diagnostic criteria of PERKI 2018. Receiver Operator Characteristic (ROC) curve analysis showed that PAPP-A was a good discriminator between AMI and non-AMI patients. The area under the curve was 0.968, 95% CI (0.932–1.004), with a sensitivity of 91.8% and specificity of 90.9% (p< 0.05). The cut-off value from the ROC curve was 2,526 ng/mL. Serum PAPP-A level has excellent performance as a biomarker for early diagnosis of AMI. It can also function as a screening instrument for the identification of UAP cases developing into AMI.
TEG's Utility to Detect Hypercoagulability in Adult Patients at Post-Cardiac Surgery Using Cardiopulmonary Bypass in ICU
Authors: Dumilah Hildegardis Dyna , Kahar Hartono , Hajat Arifoel , Setiawan Philia , Soebroto Heroe
Published: December 2020

The use of Cardiopulmonary Bypass (CPB) in adult patients of cardiac surgery disrupts the coagulation system. The mostcommon complication of the coagulation system is bleeding; however, that does not rule out the possibility of a dangeroushypercoagulation condition. A quick and precise coagulation test can provide clues for clinicians to predict futurehemostatic disorders or determine interventional therapy. aPTT and PT are standard laboratory tests, which are limited todetect a deficiency of coagulation factors. Thromboelastography (TEG) test (R time, K time, Î± angle, MA, and LY30) providesan overview of the entire coagulation and fibrinolysis process with faster results. A 2.7 mL citrate blood sample was takenand tested in a TEG®5000 device, then centrifuged. The plasma was then tested for aPTT and PT using the Sysmex CS-2100idevice. Bleeding volume was measured from chest drain 1-2 hours in the ICU after chest closure in the operating room.Bleeding criteria were as follows: > 1.5 mL/kg/hour for 6 hours consecutively in 24 hours or > 100 mL/hour. The resultsshowed 30 patients with no clinically significant bleeding. A significant correlation was found between PT and bleedingvolume at IV hour (p=0.008, r= 0.472). There was no correlation between aPTT and TEG (R time, K time, Î± angle, MA, andLY30) with the bleeding volume at I, II, III, and IV hours. There was a hypercoagulation indication of the TEG test of 56.7%,which showed clinical importance for the patient. PT can be used to analyze changes in bleeding volume at IV hour and TEGis more superior to detect hypercoagulability of adult patients after cardiac surgery with CPB.
Влияние твердости бетона на его сопротивление ледовой абразии
Authors:   Т.Э. Уварова, Е.Е. Помников, А.А. Скляров, Н.С. Назаренко
Published: December 2020

Предшествующая авторская разработка метода применения твердометрии для оценки сопротивления бетона истирающему воздействию льда позволила обосновать возможность использования этого метода для получения прямого количественного показателя стойкости бетона к ледовой абразии. В настоящей статье предпринята попытка определить сопротивление ледовой абразии всех структурных элементов состава бетона как в отдельности, так и совместно, с возможностью дальнейшего управления сопротивлением бетонных сооружений истиранию льдом. Выполнено обоснование методики представления результатов измерения твердости поверхности бетонных образцов и даны рекомендации по их статистической обработке. Представлена номограмма сопротивления бетона ледовой абразии в зависимости от твердости цементного камня и в зависимости от твердости бетона по всей поверхности образца (общая твердость бетона). Проведенные авторами испытания твердости различных составов бетона позволили сопоставить оценку твердости и сопротивления ледовой абразии, на этом основании появилась возможность прогнозировать сопротивление ледовой абразии бетонов, которые следует применять в зоне ледовых воздействий инженерных сооружений.
Ключевые слова: твердость, бетон, истирание, долговечность, ледовое воздействие
INFLUÊNCIA DE ADUBOS LÍQUIDOS NA PRODUÇÃO DE ESPIGA DE MILHO VERDE IRRIGADO
Authors: MUNHOZ Igor Rodolfo , SOBRAL Adriel José , NAKAO Allan Hisashi
Published: December 2020

Nos últimos anos, os fertilizantes líquidos começaram a ter uma demanda maior no mercado agrícola, contudo ainda se busca melhorar a metodologia de aplicação. Assim, neste trabalho, buscou-se avaliar a eficiência de produtos líquidos via fertirrigação sobre os aspectos de desenvolvimento e de produtividade da cultura do milho verde irrigada por gotejamento. O delineamento experimental foi constituído por 3 modalidades de adubação: Adubação Mineral (padrão da fazenda), adubação líquida com concentração de 50% e 100%, com 4 modelos de adubação em cobertura, a testemunha (padrão da fazenda) e líquido, nas proporções de 50%, 100% e 150%. Foram avaliados diâmetro basal do colmo, altura da planta e da inserção da espiga principal, comprimento da espiga, porcentagem e números de espigas comerciais, massa fresca e seca da planta, massa fresca e seca da espiga. A aplicação dos adubos líquidos por fertirrigação na cultura do milho influenciou positivamente nas características agronômicas e produtividade de massas.

 

THE INFLUENCE OF LIQUID FERTILIZERS OVER IRRIGATED SWEET CORN EAR PRODUCTION

 

ABSTRACT

Over the last years, liquid fertilizers have been more demanded in the agricultural market, however, we are still in search of improvements for their applying methodology. Thus, this paper aims at evaluating the effectiveness of liquid products via fertirrigation over the development aspects and productivity when growing drip-irrigated sweet corn. The trial designer comprised 3 fertilization types: Mineral Fertilization (farm standard), 50% and 100% concentrated liquid fertilization, with 4 fertilization types for covering, testimonial (farm standard), and liquid in the proportions 50%, 100%, and 150%. The basal diameter of the reed, as well as the plant height and main ear insertion, percentage and number of commercial corn ears, fresh and dry mass of the plant, fresh and dry mass of the ear. The liquid fertilizer application via fertirrigation in sweet corn crops influenced positively in agronomic characteristics and mass productivity.

 

Keywords: Sandy soil;  Zeamays; Nutrients.
An Upsurge of the novel sub-acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic: A systematic review
Authors: SACHAN ROHAN SAMIR KUMAR , UPADHYAY ATUL KUMAR , DOHROO ARADHANA , KARNWAL ARUN
Published: December 2020

The current pandemic has been declared as a Public Health Emergency of International Concern (PHEIC) by the World Health Organization (WHO) on January 30, 2020. The causative agent of the COVID-19 is Sub-Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) that causes lung severe disease, is an enveloped RNA virus. The bats being the main zoonotic reservoir of the virus. As of July 9, 2020, the number of cases has around 11,841,326 cases, with 544,739 death cases worldwide. Surveillance of the asymptomatic carriers, the certain lockdown of the public places, quarantine of 14 days of suspected individuals, or other necessary steps have been taken by each country to limit the coronavirus infection. Many scientists have worked on drug repositioning of already available drugs to compete and kill the virus. The following literature review has been conducted from the publicly available information about the evolutionary relationship, genetics, pathogenesis, clinical manifestation, diagnosis, or laboratory tests of the virus. We have also covered the available control or precautionary measures, and treatment against the virus.
Optimization of Myo-inositol hexakisphosphate phosphohydrolase (MIPH) production and enhancement of hydrocarbons degradation by purified MIPH
Authors: TANG HUACHENG , ZHANG DONGJIE , WANG CHANGYUAN , LI ZHIJIANG
Published: December 2020

Objective: The present study characterizes bacteria with biodegradation ability and optimize the growth conditions of Myo-inositol hexakisphosphate phosphohydrolase (MIPH). Methods: Out of the 15 bacterial isolates, one strain SM01 showed the highest MIPH activity was selected based on the diameter of halo zone formation on calcium phytate plates. SM01 strain was identified as a Serratia marcescens with the highest phytate activity which was further confirmed by partial sequencing of the 16S rRNA gene. Results: MIPH enzyme was purified from Serratia strain which was found to exhibit a highly-specific MIPH activity and high specificity to the phytic acid but negligible activity against the other substrates tested. The purified MIPH enzyme had an isoelectric point of 6.8 and Molecular weight to 60 kDa. The degradative ability of Serratia marscescens shown that both the culture and the purified enzyme had maximum MIPH activity at the 36 h of incubation. 0.5 U/ml concentration of the purified MIPH enzyme was found to show similar activity as the 108 cfu/ml culture tested. Conclusion: Serratia marcescens SM01 strain was capable of degrading hydrocarbons due to their varied strategies to produce the MIPH enzyme. This could be made useful in the biodegradation of polluted soils and the environment.
Differential expression of NLRP3 inflammasome genes in HPV infected cervical cells
Authors: STROE ROXANA , MAMBET CRISTINA , CURICI ANTOANELA , IVAN FLORENTINA , ALEXA LIDIA , MORJAN CLAUDIU , HODIS NISTORETA , MATEI LILIA , DRAGU LAURA DENISA , LAZAR VERONICA , BLEOTU CORALIA
Published: December 2020

The aim of this study was to to evaluate and correlate the expression of some actors of canonical inflammasome pathway with the degree of cervical lesions in cytologic specimens. Methods: The study group included 128 Romanian female patients aged between 16 and 68 years that were referred to Synevo laboratories for performing both a cytological evaluation and HPV genotyping. Results: Out of 128 analysed patients 112 (87.5%) had a positive HPV result (with one or more HPV genotypes), as follows: 34 (26.6%) patients with high-risk HPV (hrHPV) genotype(s) only, 36 (28.1%) cases with low-risk HPV (lrHPV) genotype(s) only, and 42 (32.8%) patients with combined hrHPV and lrHPV (hrHPV+lrHPV) genotypes. Our study indicate the possibility that NLRP3 inflammasome is differentially activated in HPVinfected cervical cells according to HPV oncogenic potential (hrHPV versus lrHPV) and degree of cervical lesions. Conclusion: NLRP3-independent mechanisms, such as decrease of IL1B and IL18 transcription in association with high-grade cytological lesions, could be part of the immune escape strategy used by HPV to ensure its persistence in the host cervical cells.
Extracellular enzymatic activities in the aquatic ecosystems of the Danube Delta. 2. Alkaline phosphatase activity
Authors: PĂCEŞILĂ IOAN , RADU EMILIA
Published: December 2020

Phosphorus is one of the most important inorganic nutrients in aquatic ecosystems, the development and functioning of the phytoplankton communities being often correlated with the degree of availability in assimilable forms of this element. Alkaline phosphatase (AP) is an extracellular enzyme with nonspecific activity that catalyses the hydrolysis of a large variety of organic phosphate esters and release orthophosphates. During 2011-2013, AP Activity (APA) was assessed in the water column and sediments of several aquatic ecosystems from Danube Delta: Roșu Lake, Mândra Lake and their adjacent channels – Roșu-Împuțita and Roșu-Puiu. The intensity of APA widely fluctuated, ranging between 230-2578 nmol p-nitrophenol L-1h-1 in the water column and 2104-15631 nmol p-nitrophenol g-1h-1 in sediment. Along the entire period of the study, APA was the most intense in Roșu-Împuțita channel, for both water and sediment samples. Temporal dynamics revealed its highest values in summer for the water column and in autumn for sediment. Statistical analysis showed significant seasonal diferences of the APA dynamics in spring vs. summer and autumn for the water column, and any relevant diferences for sediment.
Carrier frequencies for thrombophilia-related genetic variants in a Romanian cohort
Authors: TOPOLEANU SIMONA , MAMBET CRISTINA , MARUTESCU LUMINITA , IVAN FLORENTINA , CUCU IRINA ALINA , CURICI ANTOANELA , STOICA ILEANA
Published: December 2020

Genetic testing for hereditary thrombophilia, an inherited predisposition to thrombotic events, is increasingly available. To evaluate the rate of positive thrombophilia tests in our laboratory we analyzed the carrier status for common thrombophilia-related gene variants in a consecutive unselected cohort of 360 Romanian patients. Genetic tests were performed on a Real-Time PCR platform. Majority of patients (98.6%) carried at least one thrombophilic variant. The carrier frequencies for classical prothrombotic mutations in F5 (Factor V Leiden) and F2 genes (prothrombin G20210A mutation) were 11.67% (10.27% heterozygous, 1.4% homozygous) and 6.95% (6.39% heterozygous, 0.56% homozygous), respectively. Concurrently, high carrier frequencies for MTHFR c.677C>T, MTHFR c.1298A>C, and PAI-1 4G/5G variants, that are controversially associated with thrombophilia, were observed: 65.28% (52.5% heterozygous, 12.78% homozygous), 53.61% (45% heterozygous, 8.61% homozygous), and 78.61% (49.44% heterozygous, 29.17% homozygous), respectively. The impact of MTHFR genotypes on plasma homocysteine levels was also determined. Male carriers of TT homozygous genotype and CT heterozygous genotype of MTHFR C677T polymorphism had significantly higher levels of plasma homocysteine unrelated to age, compared to those harboring CC homozygous genotype (P=0.028). In unselected patients a high rate of positive thrombophilia tests was observed and the clinical implications of such results need to be carefully examined.
In vitro evaluation of fungicide and bio-fungicides against isolates of Alternaria solani Sorauer
Authors: MIHAESCU CRISTINA , STURZEANU MONICA , DIN ALIN
Published: December 2020

In vitro control of Alternaria solani included studies of different fungicides, essential oils basil and ethyl extract of Allium cepa. In Romania in the case of tomato culture it is very low due to several production constrains including diseases. One such disease is the early blight caused by fungus Alternaria solani (Ell.) Martin. The isolate used in this study was obtained from tomato and it was cultivated on three culture media: potato dextrose agar (PDA), malt extract agar and Czapek Dox medium. Using chlorothalonil, thiophanate methyl, prochloraz, tebuconazole and cooper sulphate, they were evaluated in order to control colony growth of fungi, at the concentrations recommended in agriculture by the specialized literature. The extract of Allium concentration with three levels (3%, 75% and 100%) significantly stronger effect on reducing mycelia growth, reducing spore germination and causing high inhibition percentage of A. solani. The fungal effect of the essential oil basil is very low being close to that of the control.
SPIES optical biopsies in laryngeal papillomatosis. The 4 waves sign
Authors: ZAINEA VIOREL , IONITA IRINA GABRIELA , PITURU SILVIU , PIETROSANU CATALINA , RUSESCU ANDREEA , STEFANESCU CRISTIAN DRAGOS , GHERGHICEANU FLORENTINA , ANGHELINA FLORIN , PALADE DRAGOS , AMZA OANA ELENA , HAINAROSIE RAZVAN
Published: December 2020

Laryngeal papillomatosis represents a challenging disease for the ENT surgeon. It has a recurrent pattern, with lesions that tend to be more and more extensive and affect the quality of life of the patient. Due to it’s viral etiology, multiple medical therapies have been attempted for these patients. Their results are still somewhat controversial, taking into account the local and systemic side effects. Diabetes mellitus (DM) patients are considered to be relatively immunocompromised and the laryngeal papillomatosis is more severe. The lesions occur at an epithelial level. The earlier the diagnosis, the better the outcome of the patient. The advancements made in the field of medical technologies made possible ample surgical interventions that maintain the natural airway. Out of these, the most used today is the CO2 LASER, with good results when correctly managed. The purpose of this paper is to present the use of an endoscopic method of examination, that uses SPIES filters, for a more accurate diagnosis of the epithelial lesions, which allows a better evaluation and more thorough follow-up of our patients. We believe attention should be paid to this topic due to the surgical, epidemiological and biological reasons.
Derrida: Deconstruction of the Ethical-Legal-Political. Methodological Clarification
Authors: Fecondo Alfredo
Published: December 2020

The answer the urgent question of what is happening today we require categories that can be open and welcoming towards these epoch-changing times and consequences thereof. To Nietzsche’s ethical turning point, the unprecedented ethical-political crisis and the new soft totalitarianism, Derrida responds with the experience of the absolute precedence of ethics of E.Levinas. At the heart of his ethics of hospitality and deconstruction we encounter justice and law. It is precisely this dimension of the structural aporetic reciprocal interpenetration between “ethical” and “juridical” that leads to a new idea of the “political”, the highest form of which is “democracy to come”.
The Unity of Epistemology and Ontology as an Essential Interpretation of Scientific Realism
Authors: Ismailova Maria V.
Published: December 2020

Epistemology and ontology are usually regarded as independent philosophical disciplines. However, the idea of their unity provides the basis for the correct interpretation of the concept of scientific realism as the development of the idea of methodological unity in science, which allows one to distinguish various subject areas, but approach them uniformly. Thus, scientific realism is associated with scientific practice as the idea of a single interpretation of phenomena using appropriate theoretical tools.
Some aspects of the Philosophy of Religion of Friedrich Daniel Ernst Schleiermacher
Authors: Lutsenko Victoria E. , Reimer Olga A.
Published: December 2020

The paper attempts to examine in more detail some aspects of the religious philosophy of the German philosopher, theologian and preacher Friedrich Daniel Ernst Schleiermacher, which is interesting in that the German thinker did not try to discover something new, but analyzing the thoughts of other philosophers, brought them into his system, thereby showing his personality.
Youth Communities Interaction in the Scientific Environment
Authors: Petrov Vladimir V. , Persidskaya Olga A. , Sanzhenakov Alexander A.
Published: December 2020

Russian scientific schools, as special phenomenon, which formation is a consequence of the cultural and historical development of country, cannot develop in isolation: close interaction between researchers of all levels and ages is necessary. In the conditions of the development of the information society and the emerging knowledge society, not only the involvement of young people in science, but also the interpersonal interaction of young scientists who are representatives of various scientific schools and professional communities is of particular relevance.
Bankruptcy as a Way of Self-Defense of the Risk Subject
Authors: Budko Elena V.
Published: December 2020

The phenomenon of insolvency (bankruptcy) is considered as a mode of existence of the subject of risk in the projection of his socio-economic behavior (fear, anxiety, loneliness) and features of personal constitution (evasion of responsibility, restriction of freedom, being in debt, deception). The article substantiates the fact that the institution of insolvency (bankruptcy) of citizens appears as a means of resolving the conflict of interests between the debtor and its creditors, as a mechanism for protecting the socio-economic rights of an insolvent risk subject and as a way to “exit” from an unstable financial crisis situation.
The Position of Science and Scientist in the National Republicsof Siberia: A Comparative Analysis of Soviet and Post-Soviet Experience
Authors: Ablazhey Anatoly M.
Published: December 2020

The article is devoted to the analysis of ethnic scientific communities. Based on the analysis of research literature, the author comes to the conclusion that there is a local, ethnic nature of the specificity of scientific communities. This specificity is manifested primarily in the formation of a kind of “image of science and scientist”, which is especially pronounced in modernizing societies. The obtained theoretical results are illustrated by the example of the formation, evolution and current state of the scientific and educational communities of the republics of Siberia (Tuva, Khakassia, Buryatia, Altai). It is proved that the specifics of their post-Soviet development is largely due to Soviet experience, in particular when it comes to the place of a scientist in a traditional and modernized society, the role of science and education as a social elevator, the place of spheres of intellectual production in the modern social and economic structure of these regions.
Rene Descartes against Pierre Bourdain: Manifestations of the Impossibility of Compromise
Authors: Goran Vasily P.
Published: December 2020

The author considers the manifestations of R. Descartes' uncompromisingly negative reaction to the criticism of his conception of the human mind as a disembodied substance by the Church figure P. Bourdain. Descartes' rejection of the interpretation of the mind as a product of the functioning of the human material brain correlates with his underestimation of the reflexive component of human mental activity. Special attention is drawn to the fact that Descartes actually avoided a substantive debate with Bourdain on these issues, limiting himself to repeating those components of his position, the reasoned criticism of which he received from the opponent. It is recognized that in the end Descartes descended to the actually offensive characterization of Bourdain's critical assessment of Descartes' original position of radical doubt in the reality of the existence of anything, stating that he perceives this assessment as "barking". It is significant that Descartes had nothing with which to respond to Bourdain's criticism of his philosophical position in a reasoned way, and it is also shown that the philosopher considered it permissible for himself to report his opponent to his ecclesiastical superiors.
The Sceptical Problem Is a Pseudo-Problem. Open Lecture: Does the External World Exist? Part II. The Sceptical Scenario Is Meaningless
Authors: Pris Igor E.
Published: December 2020

Duncan Pritchard’s hinge-disjunctivist approach is not purely therapeutic, it represents a significant step forward. But, within it, the nature of the hinge propositions themselves is not fully disclosed. We interpret the hinge propositions as reality-rooted Wittgenstein rules.This allows us to strengthen the joint interpretation of the sceptical paradox. Finally, we express our doubts about the need for a disjunctivist component to solve/dissolve the sceptical problem. A sceptical scenario is meaningless, because any understanding involves the use of concepts, which, in turn, make sense only if they are rooted in reality. Our point of view is consistent with Jocelyn Benoist’s contextual realism, as well as with Robert Brandom’s position, according to which rationalists and materialistic reductionists share a common false semantic premise about the possibility of a clear separation and independent treatment of semantics and epistemology.
On J. Searle’s “Chinese Room” from the Hybrid Model of the Artificial Cognitive Agents Design
Authors: Dushkin Roman V.
Published: December 2020

The article presents a review of the phenomenon of understanding the meaning of the natural language and, more broadly, the meaning of the situation in which the cognitive agent is located, considering the context. A specific definition of understanding is given, which is at the intersection of neurophysiology, information theory and cybernetics. The scheme of an abstract architecture of the cognitive agent (of arbitrary nature) is offered, which states that an agent with such architecture can understand in the sense described in the paper. It also provides a critique of J. Searle’s mental experiment “The Chinese Room”
from the point of view of the construction of artificial cognitive agents within a hybrid paradigm of artificial intelligence. The novelty of the presented work is based on the application of the author’s methodological approach to the construction of artificial cognitive agents. It not only considers the perception of external stimuli from the environment, but also the philosophical problem of “understanding” by the artificial cognitive agent of its sensory inputs. The relevance of the work follows from the renewed interest of the scientific community in the theme of Strong Artificial Intelligence (or AGI). The author's contribution consists in comprehensive treatment from different points of view of the theme of understanding perceived by artificial cognitive agents. It involves the formation of prerequisites for the development of new models and the theory of understanding within the framework of artificial intelligence, which in the future will help to build a holistic theory of the nature of human mind. The article will be interesting for specialists working in the field of artificial intellectual systems and cognitive agents construction, as well as for scientists from other scientific fields – first of all, philosophy, neurophysiology and psychology.
Salud visual y ocular de escolares atendidos en una clínica universitaria oftalmológica de Cartagena de Indias (Colombia)
Authors: Alfonso-Rojas Carlos , Murcia-Rojas Karen
Published: December 2020

El presente estudio tiene como objetivo caracterizar la salud visual y ocular de los niños en las entidades atendidas por la fundación CharityVisión y Universidad del Sinú en la ciudad de Cartagena. Para la realización del proyecto se utilizó como instrumento de recolección una historia clínica, la cual fue proporcionada por la clínica oftalmológica de Cartagena, donde se llenaban todos los datos necesarios para dar un buen diagnóstico. Después se realizaron unas tabulaciones para analizar estadísticamente los datos y a partir de ellos, elaborar una serie de tablas en donde se detallan los resultados obtenidos durante el desarrollo del proyecto y así determinar la conducta que requería cada niño. Con lo anterior, se plantearon recomendaciones que permitirán dar una mejor calidad de vida a todas las personas que lo requieren. La investigación permitió concluir que es de vital importancia implementar las políticas públicas en estos casos como el programa ‘Quiero Ver’ los cuales deben existir para poder invertir más en la población vulnerable.
Características, epidemiologia e riscos do consumo do narguilé
Authors: Souza Lídia Acyole de , Rabahi Marcelo Fouad
Published: December 2020

Objetivo: Apresentar informações sobre a epidemiologia, características e riscos do consumo do tabagismo no consumo de Narguilé. Revisão bibliográfica: Fumar é considerado como uma enfermidade crónica e é relacionado à ocorrência do câncer, de doenças cardíacas e morte. Nos últimos anos, pesquisadores e governos buscaram juntos combater a pandemia tabagica. Por outro lado, o tabaco continua sendo uma das drogas mais utilizadas por jovens, principalmente quando consumido de forma não convencional. O narguilé é um dispositivo para fumar característico da cultura oriental e que popularizou no ocidente a partir dos anos 90. Estudos em diversos países tem demonstrado prevalências de utilização preocupante, e apontando a juventude como principal grupo de vulnerabilidade para a experimentação. Os riscos do consumo de narguilé vão desde maior exposição a nicotina, monóxido de carbono e outros produtos químicos, à alteração de ritmo cardíaco, doenças contagiosas e canceres. Considerações finais: Informações equivocadas têm servido para mascarar os efeitos nocivos do produto, e que o narguilé pode ser mais prejudicial que o cigarro industrial.
OUN(M) SECURITY BODIES DURING THE SECOND WORLD WAR (1940 – 1944)
Authors: Antoniuk Yaroslav , Trofymovych Volodymyr , Trofymovych Liliya
Published: December 2020

The article analyzes the activities of the security bodies of the Organization of Ukrainian Nationalists of the Melnyk direction during the Second World War. It was proven that the bodies were created by some former OUN intelligence officers, who were led by Yaroslav Haivas, in February 1940 on the territory of the General Government. In March 1941, the counterintelligence group, which was involved in identifying Bandera’s agents, of the sub-unit was separated. In the summer of 1941, the development of the OUN(M) security bodies network had begun on the territory of Western Ukraine. They resembled the OUN intelligence of the 1930-s by their structure. They reached the greatest development in southern Volyn. In the autumn of 1941, Melnyk security bodies extended their influence on Ukrainian lands to the east of Zbruch. Faced with German repression, they did not dare to confront the armed resistance, considering it was hopeless. Melnyk’s security bodies had high hopes for achieving strong positions in the occupation administration. They primarily focused on the Ukrainian Auxiliary Police. The development of the OUN(M) cells was slow even in the Western Ukraine. It mostly occured in the towns controlled by Germans. The article clarified that Melnyk’s counterintelligence forces sometimes managed to identify and even eliminate individual Bandera agents. However, they could not effectively resist the much stronger OUN (Bandera) Security Service. In the summer of 1943, Melnykivtsi were finally defeated in that confrontation. Banderites surrounded a few armed formations of the OUN(M) and attached them to the Ukrainian Insurgent Army. After those events the Melnyk movement started to decline. The last OUN(M) security service boivka operated until the autumn of 1944 in the Drohobych region.
SOVIET PRACTICE OF TEACHER TRAINING IN THE OSTROH PEDAGOGICAL SCHOOL (1939–1941, 1944–1956)
Authors: Dobrochynska Valentyna
Published: December 2020

Based on the study of new documentary sources, the Soviet practice of teacher training in the Ostroh pedagogical school from the time of its creation and until the reorganization of the institution has been comprehensively considered. The functioning of a vocational school during the two periods of the Soviet regime, separated by the German-Soviet war and the establishment of the Nazi occupation power on Ukrainian territories, has been analyzed. In the first, against the background of socio-political transformations since the accession of Western Ukrainian lands to the USSR, the reorganization of the educational sector on the Soviet model has been noted and the emphasis has been made on directives and tasks of the party leadership concerning the establishing of pedagogical schools to train teachers from the local population. The peculiarities of the system of teaching and introduction of communist education in the pedagogical school at the initial stage of Sovietization of the region have been clarified. The second, longer period of activity of the Ostroh Pedagogical School is characterized by the resumption of the educational process in the postwar years, the rise of the Soviet government after the victorious end of World War II and the continuation of the course of socialist transformation in Western Ukraine. The analysis of statistical information helped to reproduce the dynamics of the number of teachers and students, as well as to determine their national and social composition. The organizational principles and content of professional and educational training of teachers in the postwar years have been highlighted. The attention is paid to the methods and forms of ideological treatment of student youth, among which the atheism, the activities of the Komsomol organization, conducting various events on communist propaganda work have been distinguished. These factors in Soviet practice determined the basic principles of the educational process in professional training of primary school teachers.