bluuebunny/crossref_metadata_2025 huggingface dataset:
Resin-supported nanoiron: A powerful tool for heavy metal decontamination - Elucidating the mechanism through column studies
Authors: Mystrioti Christiana , Papassiopi Nymphodora , Xenidis Anthimos
Published: January 2025

The significance of removing heavy metal ions from wastewater treatment plant effluents cannot be overstated in preserving a clean environment and protecting human health. Various methods, including adsorption, membrane-based processes, chemical treatments, electrical methods, and photocatalysis, have been documented for the effective removal of heavy metal ions from different wastewater sources. Nanoparticles, with their strong affinity, show promise in wastewater treatment, particularly in efficiently extracting heavy metals. This study aimed to evaluate the effectiveness of an iron nanocomposite, RnFe, in eliminating various heavy metals from effluents of wastewater treatment plants through column tests. RnFe is composed of iron nanoparticles supported in an inert cationic resin, produced using green tea extract as a reducing agent for Fe(III) to Fe(0). The introduced feed solution to the columns contained a mixture of heavy metals, including Cr(VI), As, Ni, Pb, Cu, Cd, and Zn. The study investigated the impact of contact time on the sorption and reduction rates of the selected compounds, varying contact times to 2.4, 4.8, and 6 minutes. RnFe demonstrated high efficiency in removing Cr(VI) and As, with effluent concentrations meeting environmental limits when the contact time exceeded 5 minutes. However, the performance of RnFe was less effective for divalent metal contaminants due to the strong competitive effect of coexisting Ca. The study provided a succinct exploration of the mechanisms involved in using the RnFe nanocomposite for the removal of metals and metalloids.
Strong and Weak Hypotheses
Authors: Chiffi Daniele , De Florio Ciro
Published: January 2025

I
In this paper, we investigate the nature of empirical hypotheses used in scientific reasoning and the act of formulating hypotheses. This is achieved through a novel logical framework in which we provide specific semantics for two types of hypotheses: a strong and a weak sense of hypothesis, each characterized by different logical structures. This framework enables us to better characterize certain aspects of hypothetical reasoning in scientific practice, especially when we attempt to rationally deny the content of an empirical hypothesis.
Imaging Diagnostics, Biomarkers, and Emerging Trends in Orthopedic Research and Treatment
Authors: Trestka Gabriela , Domino Wiktoria , Zelik Urszula , Przygoda Maria , Śnieżna Joanna , Stępień Kamila , Adamczyk Sabina , Florczak Wojciech , Włodyka Jagienka , Dziewic Jakub , Dzwonnik Karol
Published: January 2025

With an aging population, increasing sports participation, and a rising number of obese individuals, researchers are addressing the growing prevalence of musculoskeletal diseases. Early diagnosis is crucial for effective treatment and disease prevention. Imaging techniques and biomarkers are essential tools in orthopedic diagnostics, providing critical insights into disease progression, treatment efficacy, and clinical outcomes prediction.
This paper offers an overview of key imaging modalities, including X-ray, CT, MRI, ultrasonography, scintigraphy, and fluorescence tomography (FLAIR), highlighting their strengths, limitations, and clinical applications. X-ray and CT are commonly used for bone-related issues, while MRI and ultrasonography are invaluable for evaluating soft tissues. Scintigraphy and FLAIR, on the other hand, are particularly effective for detecting metabolic activity and soft tissue changes.
Biomarkers, such as those used in osteoarthritis, osteoporosis, joint inflammation, and bone regeneration, complement imaging techniques by enabling early diagnosis, monitoring disease progression, and predicting treatment outcomes. The integration of biomarkers with imaging provides a more comprehensive approach to patient care.
Finally, emerging technologies like artificial intelligence, smartphones, 4DCT, and 3D printing of implants are poised to revolutionize orthopedic diagnostics and treatment. These advancements promise greater precision in diagnostics, personalized treatments, and improved patient outcomes, though challenges in implementation and technology adoption remain.
Impacto del uso del teléfono móvil en las estrategias de aprendizaje.
Authors: Rubio Hernández Francisco José , Olivo Franco José Luis , Tuesta Panduro Alfredo
Published: January 2025

Se indagó la relación entre el uso del teléfono móvil (TM-S) y las estrategias de aprendizaje (EA) en una muestra de 1518
estudiantes universitarios peruanos. Se llevó a cabo una investigación cuantitativa de tipo encuesta, no experimental y
diseño transversal. Se utilizaron medidas de tendencia central y se aplicaron las pruebas U de Mann-Whitney, H de
Kruskal Wallis y el coeficiente de correlación de Spearman. Los resultados obtenidos revelaron que el uso inadecuado
del TM-S estaba vinculado a un desempeño académico inferior, mayores niveles de distracción y más facilidad para
comunicarse virtualmente en vez de cara a cara. Respecto a las EA, los encuestados presentaron mayores desafíos en
el control emocional, la transferencia del conocimiento a nuevos contextos y la regulación de sus propios procesos de
aprendizaje. Estas dificultades se manifestaron en una menor capacidad para preparar con la suficiente profundidad las
tareas académicas o para concentrarse y reducir el nerviosismo durante los exámenes. Se observó que las mujeres y los
estudiantes de ciertas carreras tendían a hacer un uso más adecuado del TM-S (en ciencias de la educación y
humanidades) y a reportar mayores habilidades en el empleo de EA (en ingeniería). Por otro lado, se encontró una
correlación negativa débil entre el uso problemático del TM-S y el uso adecuado de las EA. Esto indica que a medida que
aumenta el uso problemático del TM-S, disminuye el uso de estrategias de aprendizaje efectivas. De este modo, los
hallazgos subrayan la importancia de diseñar intervenciones educativas que promuevan el uso responsable del TM-S, el
desarrollo de competencias digitales y la adquisición de habilidades de aprendizaje autónomo, lo cual podría contribuir a mejorar el rendimiento académico y a formar ciudadanos digitales más competentes.
Desarrollo y Evaluación Psicométrica del Inventario Multigrupal de Identidad Étnica.
Authors: SUHERMAN SUHERMAN , Vidákovich Tibor
Published: January 2025

Despite widespread use, there is limited research evaluating the psychometric properties and measurement invariance of
the Multigroup Ethnic Identity Inventory (MEI2) across diverse populations. Current approaches to measuring Ethnic
Identity often lack relevance to diverse cultural contexts, especially in the Indonesian context and among secondary
students. This study investigates the psychometric properties of the MEI2 among Indonesian secondary school students
representing diverse ethnic backgrounds. The participants consisted of 276 secondary school students (60.1% female;
39.9% male). Confirmatory factor analysis verified the validity of the MEI2, with the goodness-of-fit index indicating that
the model was economical and reasonable. Furthermore, the correlation between the three domains revealed a significant
positive relationship. The findings support the MEI2 as a valid instrument for assessing students' ethnic identity in this
specific context. The contribution of this research is to be fostering diverse-friendly learning environments and supports
educators in acknowledging and embracing the complexities of students' ethnic identities within Indonesian cultural
landscapes.
Alternativas estratégicas para el desarrollo de negocios verdes productivos del Caquetá (Colombia)
Authors: Peña Torres Parcival , Marlés Betancourt Claritza , Capera García Camilo Esteban
Published: January 2025

Objetivo: el artículo tiene como propósito identificar alternativas para el desarrollo de negocios verdes en las asociaciones productivas del municipio de Florencia (Caquetá, Colombia). Metodología: se empleó una investigación descriptiva con enfoque mixto que permitió la aplicación del foda cualitativo y cuantitativo a una muestra de diez asociaciones agropecuarias de la región, como técnica que permite elaborar el diagnóstico organizacional y la correlación de estrategias para la población estudiada. Resultadosprincipales: los resultados develan la integración de fortalezas, oportunidades, debilidades y amenazas; así como la definición de estrategias que repercuten de forma en el posicionamiento de las asociaciones. Conclusiones: en definitiva, son pertinentes estrategias como el mejoramiento en la eficiencia de la gestión de la cadena de suministro, el exigir el cumplimiento de estándares sostenibles por parte de los proveedores, la necesidad de reducir al mínimo el desperdicio y el impacto ambiental en todas las etapas del proceso productivo, al igual que la estructuración de un comité enfocado en la implementación de procesos de calidad y el diseño de estrategias de marketing para promover sus productos en mercados especializados en productos ecológicos.
Effects of the Mindfulness-Based Cognitive Therapy (MBCT) program on college students' mindfulness, perceived stress, depression, experience avoidance, and trait anxiety
Authors: Ahn Seyun
Published: January 2025

The purpose of this study was to investigate the effects of mindfulness-based cognitive therapy (MBCT) programs on mindfulness, perceived stress, depression, experience avoidance, and trait anxiety of college students. Participants in the study conducted the MBCT program from April to June 2024 for 35 students who participated in liberal arts classes at K University in Daejeon. For measurement, the mindfulness 5-factor scale, perceived stress scale, depression scale (CES-D), multidimensional experiential avoidance scale, and trait anxiety scale were measured before and after the program. The research results are as follows. First, the MBCT program was found to increase the level of mindfulness in college students. In particular, among the sub-factors of mindfulness, significant changes were found in observing, non-reactivity, and describing. Second, the MBCT program did not show any change in the perceived level of stress among college students. Third, the MBCT program did not show any change in the level of depression in college students. Fourth, the MBCT program was found to reduce the level of experiential avoidance of college students, and among the sub-factors of experiential avoidance, there were significant changes in procrastination and behavioral avoidance. Fifth, the MBCT program did not show any change in the level of trait anxiety of college students. Finally, the limitations and supplements of this study were presented.
A Qualitative Study on the Participation Experience in a Yoga Meditation Program Based on the Saseobbeop
Authors: Min Sunmi
Published: January 2025

The purpose of this study is to explore the physical and psychological change experiences of women after middle age through a yoga program. The research question for this is; First, what are the physical changes that occur through participation in a yoga meditation program based on the Saseobbeop? Second, what is the internal change through participation in a yoga meditation program based on the Saseobbeop? Third, when participating in a yoga meditation program based on the Four Substances, who was the target of the Saseobbeop? Written interviews were conducted with 39 participants in a yoga meditation program based on the Saseobbeop and analyzed using a modified consensus qualitative research (CQR-M) method. As a result of the analysis, 12 sub-areas were derived focusing on the three areas. Through this study, we reveal the changing experiences of post-middle-aged women with yoga meditation based on the Saseobbeop, thereby increasing the physical and emotional understanding of post-middle-aged women and establishing a way for post-middle-aged women to receive help not only through physical activity but also through Buddhism. The intention was to provide basic information.
Revitalizing upper blepharoplasty: Preserving volume
Authors: Farsakoury Rana , Nashwan Abdulqadir J
Published: January 2025

Blepharoplasty is a frequently performed aesthetic surgery today aimed at enhancing eyelid appearance and correcting age-related changes. The traditional method of subtraction blepharoplasty, which involved removing fat and excess skin, is now considered outdated. This letter explores Gorgy et al 's commentary on Miotti et al 's study, highlighting a shift in upper eyelid blepharoplasty towards a more conservative, volume-preserving approach. The study systematically reviewed 10 publications, including three retrospective studies, five comparative studies, and two clinical trials. It emphasizes the trend towards preserving the patient's natural anatomy and focusing on enhancement rather than alteration. However, the study's limitations, such as the lack of long-term comparative research, a relatively small sample size, and a single-center design, indicate that further research with extended follow-up is necessary to validate the safety and effectiveness of these techniques. The focus is increasingly on preserving and augmenting volume in upper blepharoplasty rather than removing tissue.
Artificial intelligence and the impact of multiomics on the reporting of case reports
Authors: Boini Aishwarya , Grasso Vincent , Taher Heba , Gumbs Andrew A
Published: January 2025

The integration of artificial intelligence (AI) and multiomics has transformed clinical and life sciences, enabling precision medicine and redefining disease understanding. Scientific publications grew significantly from 2.1 million in 2012 to 3.3 million in 2022, with AI research tripling during this period. Multiomics fields, including genomics and proteomics, also advanced, exemplified by the Human Proteome Project achieving a 90% complete blueprint by 2021. This growth highlights opportunities and challenges in integrating AI and multiomics into clinical reporting. A review of studies and case reports was conducted to evaluate AI and multiomics integration. Key areas analyzed included diagnostic accuracy, predictive modeling, and personalized treatment approaches driven by AI tools. Case examples were studied to assess impacts on clinical decision-making. AI and multiomics enhanced data integration, predictive insights, and treatment personalization. Fields like radiomics, genomics, and proteomics improved diagnostics and guided therapy. For instance, the “AI radiomics, genomics, oncopathomics, and surgomics project” combined radiomics and genomics for surgical decision-making, enabling preoperative, intraoperative, and postoperative interventions. AI applications in case reports predicted conditions like postoperative delirium and monitored cancer progression using genomic and imaging data. AI and multiomics enable standardized data analysis, dynamic updates, and predictive modeling in case reports. Traditional reports often lack objectivity, but AI enhances reproducibility and decision-making by processing large datasets. Challenges include data standardization, biases, and ethical concerns. Overcoming these barriers is vital for optimizing AI applications and advancing personalized medicine. AI and multiomics integration is revolutionizing clinical research and practice. Standardizing data reporting and addressing challenges in ethics and data quality will unlock their full potential. Emphasizing collaboration and transparency is essential for leveraging these tools to improve patient care and scientific communication.
MYH7 mutation in a pedigree with familial dilated hypertrophic cardiomyopathy: A case report and review of literature
Authors: Hong Ying , Fan Zhen , Guo Yi , Ma Hui-Hui , Zeng Sheng-Zhi , Xi Hu-Tao , Yang Jing , Luo Kai , Luo Rong , Li Xiao-Ping
Published: January 2025

BACKGROUND

Hypertrophic cardiomyopathy (HCM) is one of the most prevalent inherited myocardial disorders and is characterized by considerable genetic and phenotypic heterogeneity. A subset of patients with HCM progress to a dilated phase of HCM (DPHCM), which is associated with a poor prognosis; however, the underlying pathogenesis remains inadequately understood.

CASE SUMMARY

In this study, we present a case involving a pedigree with familial DPHCM and conduct a retrospective review of patients with DPHCM with identified gene mutations. Through panel sequencing targeting the coding regions of 312 genes associated with inherited cardiomyopathy, a heterozygous missense mutation (c.746G>A, p.Arg249Glu) in the MYH7 gene was identified in the proband (III-5). Sanger sequencing subsequently confirmed this pathogenic mutation in three additional family members (II-4, III-4, and IV-3). A total of 26 well-documented patients with DPHCM were identified in the literature. Patients with DPHCM are commonly middle-aged and male. The mean age of patients with DPHCM was 53.43 ± 12.79 years. Heart failure, dyspnoea, and atrial fibrillation were the most prevalent symptoms observed, accompanied by an average left ventricular end-diastolic size of 58.62 mm.

CONCLUSION

Our findings corroborate the pathogenicity of the MYH7 (c.746G>A, p.Arg249Glu) mutation for DPHCM and suggest that the Arg249Gln mutation may be responsible for high mortality.
Compact and aberration effects-shielded objective intraocular scatter measurement system
Authors: Zhao Junlei , Zhang Zitao , Yang Yanrong , Zhang Haobo , Chen Hao , Wang Shengqian , Dai Yun
Published: January 2025

The measurement of the double-pass (DP) point spread function (PSF) provides an objective, non-invasive method for estimating intraocular scatter in the human eye. In this paper, we propose a compact double-pass objective intraocular scatter measurement system that eliminates the influence of aberrations. The system includes a far-field DP PSF detection channel and a Shack-Hartmann wavefront aberration detection channel, which are used to obtain the far-field DP PSF image and 7 orders Zernike aberration coefficients, respectively. The far-field DP PSF image is used to calculate the initial objective scatter index of the human eye. The aberration coefficients are used to reconstruct the DP PSF image caused by aberrations and calculate the influence coefficient of aberrations on intraocular scatter. By subtracting this influence coefficient from the initial objective scatter index (OSI0), the effect of aberrations on scatter measurement can be eliminated, resulting in an accurate objective scatter coefficient. Experimental verification showed that when the exit pupil aperture of this system was set to 4 mm and 6 mm, the measurement accuracy increased by at least 11.9% and 28.9%, respectively, compared to before eliminating the influence of aberrations. While improving the measurement accuracy, the system also keeps the device size and manufacturing costs at a low level, making it more suitable for clinical applications.
Controlling ocular longitudinal chromatic aberration using a spatial light modulator
Authors: Pusti Dibyendu , Debnath Debajyoti , Bang Seungpil , Yoon Geunyoung
Published: January 2025

Manipulating ocular longitudinal chromatic aberration (LCA) can enhance visual outcomes in presbyopia-correcting multifocal intraocular lenses and serve as a powerful tool for investigating eye growth mechanisms. This study introduces a spatial light modulator-based visual simulator (SLMVS) that utilizes the unique properties of diffractive optics with a negative Abbe number to precisely control ocular LCA, allowing for its correction or reversal. The system was validated through optical bench tests using a model eye and human subjects. Bench test results under polychromatic light showed improved image quality close to monochromatic performance when LCA was corrected at the far focus of both monofocal and trifocal lenses. In human tests, the SLMVS achieved a mean LCA correction of 0.01 ± 0.13 D and a mean LCA reversal of –1.62 ± 0.40 D, compared to an average ocular LCA of 1.41 ± 0.25 D.
Localized bulk states in a double-layer trimer lattice model with intra- and inter-cell symmetry
Authors: Xia Chenrong , Jiang Tao , Li Xiangnan , Xin Guoguo , Zhang Wenjing
Published: January 2025

We investigated the light transmission in a double-layer trimer lattice model. For the case of intra- and inter-cell symmetry (IIS), a phenomenon of light localized transmission within the last (C) and the first (A) waveguides in the preceding and the succeeding unit cells exists in this model. When the light is incident from one or two of the adjacent A and C waveguides with the appropriate phase differences during the condition of IIS, a kind of localized oscillating light transmission phenomenon between the two waveguides appears. The local transmission of the light corresponds to a bulk state, which is caused by the eigenstates of the allowable bands in the photon band, and it is different from the common edge states that appear in the forbidden band region of the photon energy band. The local state arises from the zero group velocity of the wave packet, which satisfies the condition of IIS. By solving the evolution equations of a two-unit-cell model with IIS, we obtain an expression of light transmission between the adjacent A and C waveguides, which can be used to describe the light transmission phenomenon under various incident conditions. The stability of localized beams is explored by breaking the symmetry. We can manipulate the oscillating localized light transmission effectively by adjusting the hoppings of the intra- and inter-cells.
Connectome-based biophysical models of pathological protein spreading in neurodegenerative diseases
Authors: Ren Peng , Cui Xuehua , Liang Xia
Published: January 2025

Neurodegenerative diseases are a group of disorders characterized by progressive degeneration or death of neurons. The complexity of clinical symptoms and irreversibility of disease progression significantly affects individual lives, leading to premature mortality. The prevalence of neurodegenerative diseases keeps increasing, yet the specific pathogenic mechanisms remain incompletely understood and effective treatment strategies are lacking. In recent years, convergent experimental evidence supports the “prion-like transmission” assumption that abnormal proteins induce misfolding of normal proteins, and these misfolded proteins propagate throughout the neural networks to cause neuronal death. To elucidate this dynamic process in vivo from a computational perspective, researchers have proposed three connectome-based biophysical models to simulate the spread of pathological proteins: the Network Diffusion Model, the Epidemic Spreading Model, and the agent-based Susceptible-Infectious-Removed model. These models have demonstrated promising predictive capabilities. This review focuses on the explanations of their fundamental principles and applications. Then, we compare the strengths and weaknesses of the models. Building upon this foundation, we introduce new directions for model optimization and propose a unified framework for the evaluation of connectome-based biophysical models. We expect that this review could lower the entry barrier for researchers in this field, accelerate model optimization, and thereby advance the clinical translation of connectome-based biophysical models.
F-box protein Fbx23 acts as a transcriptional coactivator to recognize and activate transcription factor Ace1
Authors: Liu Zhongjiao , Ma Kexuan , Zhang Panpan , Zhang Siqi , Song Xin , Qin Yuqi
Published: January 2025

Protein ubiquitination is usually coupled with proteasomal degradation and is crucial in regulating protein quality. The E3 ubiquitin-protein ligase SCF (Skp1-Cullin-F-box) complex directly recognizes the target substrate via interaction between the F-box protein and the substrate. F-box protein is the determinant of substrate specificity. The limited number of identified ubiquitin ligase-substrate pairs is a major bottleneck in the ubiquitination field. Penicillium oxalicum contains many transcription factors, such as BrlA, CreA, XlnR, and Ace1, conserved in filamentous fungi that regulate the fungal development and transcription of (hemi)cellulase genes. Transcription factor Ace1 (also known as SltA) positively correlated with fungal growth and conidiation and negatively correlated with the expression of (hemi)cellulase genes. A ubiquitin ligase-substrate pair, SCFFbx23-Ace1, is identified in P. oxalicum. Most of PoFbx23 is present in free form within the nucleus. A small portion of PoFbx23 associates with Skp1 to form PoFbx23-Skp1 heterodimer or assembles with the three invariable core components (Skp1, Cul1, and Rbx1) of SCF to form the SCFFbx23 complex. Under glucose signal, PoFbx23 absence (Δfbx23) results in decreased transcription levels of the brlA gene which encodes the master regulator for asexual development and six spore pigmentation genes (abrB→abrA→aygB→arpA→arpB→albA) which encode the proteins in the dihydroxynaphthalene-melanin pathway, along with impaired conidiation. Under cellulose signal, transcription levels of (hemi)cellulase genes in the Δfbx23 mutant are significantly upregulated. When PoFbx23 is present, PoAce1 exists as a full-length version and several low-molecular-weight degraded versions. PoAce1 has polyubiquitin modification. Deleting the Pofbx23 gene does not affect Poace1 gene transcription but results in the remarkable accumulation of all versions of the PoAce1 protein. Accumulated PoAce1 protein is a dysfunctional form that no longer binds promoters of the target gene, including the cellulase genes cbh1 and eg1, the hemicellulase gene xyn11A, and the pigmentation-related gene abrB. PoFbx23 acts as a transcriptional coactivator, recognizing and activating PoAce1, allowing the latter to regulate the transcription of target genes with different effects (activating or repressing) under different signals.
Mortality among 5 to 19-year-olds in rural Mali
Authors: Liu Jenny X. , Samake Yacouba , Tolo Oumar , Treleaven Emily , Poudiougou Belco , Whidden Caroline , Johnson Ari , Kayentao Kassoum , Boettiger David C.
Published: January 2025

The unique healthcare needs of 5 to 9-year-olds and adolescents (10–19 years) in low- and middle-income countries have been largely neglected. We generated estimates of 5 to 9-year-old and adolescent mortality in rural Mali, a setting with high under-five mortality, and aimed to define associated individual and household risk factors. We analysed cross-sectional baseline household survey data from the ProCCM trial (NCT02694055) conducted in Bankass District, Mali collected in December 2016 and January 2017. Deaths in the preceding five years, household information, and women’s birth histories were documented. Factors associated with 5 to 9-year-old and adolescent mortality were analysed using Cox regression. Our study population comprised 23,485 children aged 5 to 9-years-old and 17,910 adolescents from 7,720 households. The 5 to 9-year-old and adolescent mortality rates were 3.10 and 1.90 deaths per 1,000 person-years, respectively. Mortality rates were similar among males and females aged 5 to 9 years, but grew increasingly divergent in adolescence (1.69 and 2.17 per 1,000 person-years, respectively). Five to 9-year-olds in households with untreated water had a higher risk of death than those in households with treated water. Adolescents living in the poorest households had a higher risk of death than those in the wealthiest, and adolescents in households in which no women received schooling had a higher risk of death than those in which women had some schooling. The risk of mortality was especially acute among female adolescents compared to their male counterparts, with low access to education for women being a strong contributing factor.
The relationship between business competition and welfare in Indonesia
Authors: Setiawan Maman , Indiastuti Rina , Effendi Nury
Published: January 2025

This research freshly investigates the effect of business competition on national welfare in Indonesia. This research uses business competition index data obtained from the Indonesia Competition Commission (KPPU) and welfare indicators data collected from the Indonesian Bureau of Central Statistics (BPS) at the economic sectoral and provincial levels for the period 2018–2020. The relationship between business competition and welfare is estimated using pooled regression model combining year, economic sector, and province. This research also uses business competition index applying both same weights for all dimensions of competition and the weights derived from principal component analysis. This research finds that business competition has a positive effect on welfare as represented by gross regional domestic product, regional productivity, productivity growth, wages, and human development index. Furthermore, the regions with high scores on the competition index mostly come from Java Island. Therefore, Indonesian government must encourage the mainstreaming of business competition in all provinces in Indonesia.
Extraction efficiency and bioactive evaluation of Tamarix nilotica and Arthrocnemum macrostachyum extracts for anti-cancer potential
Authors: Al Kaabi Maryam , ElNaker Nancy A. , Jan Nila , Ochsenkühn Michael A. , Amin Shady A. , Yousef Lina F. , Yousef Ahmed F.
Published: January 2025

This study aimed to evaluate the potential of phytochemicals from two native UAE plant species, Arthrocnemum macrostachyum and Tamarix nilotica, as anti-cancer agents. The plant extracts were obtained using two methods, maceration, and microwave-assisted extraction (MAE), and were subsequently evaluated for their in vitro cytotoxicity against three cancer cell lines: breast (MDA-MB-231), colon (HCT-116), and lung (A-549). Results suggest that: 1) MAE is more efficient than maceration in recovering metabolites from plant biomass based on measurements of total phenolic content, radical scavenging activity, and bioactivity of extracts based on in vitro cytotoxicity. 2) Only T. nilotica extracts were found to be bioactive based on cytotoxicity measurements. 3) Cancer cell lines displayed differential sensitivity to T. nilotica crude extracts, with breast cancer cells being the most sensitive and lung cancer cells being the least sensitive. 4) Solid-phase fractionation of T. nilotica crude extract using different percentages of methanol resulted in several fractions that were 100-fold more cytotoxic compared to the crude unfractionated extract. The 30% and 70% methanol fractions exhibited the highest cytotoxicity towards breast and colon cancer cell lines, respectively. 5) Untargeted metabolomics using UHPLC-Q-ToF-MS of T. nilotica crude extracts revealed 909 molecular features, of which only 327 were annotated using MS/MS fragmentation. The results suggest that T. nilotica extracts have potential as anti-cancer agents and that MAE is an efficient method for extracting phytochemicals from plant biomass. The study also revealed that cancer cell lines exhibited differential sensitivity to the extracts and that solid-phase fractionation of crude extract using different percentages of methanol can yield fractions that are more cytotoxic than the crude extract.
Monsters Among Us: In What Ways Can the Viral Jubilee’s Trans Debate Video Contribute to Educational Discussions?
Authors: Peng Sheng-Hsiang Lance
Published: January 2025

This article leverages Jubilee’s viral YouTube video featuring conservative and liberal trans individuals debating as a means to promote the integration of e-materials in discussions about the entitlements and human worth of trans communities, with special attention to vital rights like toilet access and including nonbinary persons. Using perspectives informed by hauntology and monster theory, I contend that educators can benefit from these conceptual frameworks. Hauntology is a philosophical concept introduced by Jacques Derrida, focusing on the idea of the persistence of the past within the present and the impact of forgotten or repressed histories on contemporary culture. It explores how the «spectres» of past events and ideologies continue to influence and haunt current social and cultural contexts. Monster theory, on the other hand, is a framework developed by Jeffrey Jerome Cohen that examines how monsters in literature and folklore serve as symbols for societal anxieties and cultural conflicts. It interprets monsters as embodiments of societal fears, otherness, and transgressions, bringing to light key elements of cultural norms and human psychology. Both present viewpoints on looking into how the past and cultural anxieties shape our present realities. The discussion in this paper includes pedagogical tools that address transgender experiences, such as the seven facets of Socratic seminars designed to foster conversations on cosmopolitan ideals of diversity. Additionally, the value of guiding students to consistently question «who, where, and why» is emphasised, with a focus on how a monstrous lens can contribute to the enhancement of developmental learning experiences. This article addresses both educators and enthusiasts of gender perspectives, advocating for teaching environments that enable students to explore a world beyond societal expectations. It also appeals to those interested in hauntology and monstrous lens theory, encouraging the integration of these theories to advance educational development.
She’s Such a Bitch! The Representation of Women as Bitches in Gender-Based Violence Campaigns
Authors: López-Rodríguez Irene
Published: January 2025

This paper examines the representation of women as «bitches» in gender-based violence campaigns. It analyzes a purpose-built corpus consisting of 22 campaigns from 17 countries dated from 1999 to 2023 that represent women as «bitches». Many of these campaigns have been financed by general and state governments; others, by non-governmental organizations or associations in defense of children. Some campaigns have been created on the internet; others are based on the lyrics of popular songs and even on street graffiti. Some take the form of posters, television and radio commercials and even documentaries. They constitute, therefore, a wide and diverse repertoire of gender-based violence campaigns. The project considers the linguistic, visual and acoustic representations of women as bitches given that several campaigns juxtapose photographs of battered women and real female dogs, characterize women as literal bitches by portraying them kneeling and with a leash around their necks held by a man and evoke the canine image through word play and onomatopoeia. The study employs the metaphor identification procedure for the spotting and coding of the metaphoric «bitch». Through the lens of Conceptual Metaphor Theory, the paper shows that gender-based violence campaigns resort to «bitch» to illustrate how this commonplace slur contributes to the dehumanization, objectification, sexualization and belittlement of women. It also shows that, despite the cultural and linguistic differences of the countries where the campaigns have been produced (Spain, Mexico, Colombia, Peru, China, the UK, Canada, the USA, Australia, France, Lebanon, Italy, Norway, Denmark, etc.), «bitch» is at the core of gender-based violence. The article, ultimately, demonstrates the close link between «bitch» and (the language of) gender-based violence.
EXTENDED DISTRIBUTION OF TWO WOODPECKER SPECIES (Micropternus brachyurus and Picus vittatus) IN MERU BETIRI NATIONAL PARK, EAST JAVA, INDONESIA
Authors: Siddiq Arif Mohammad , Firmansyah Puji , Kurnianto Agung Sih , Kurniawan Muhammad , Kholiq Nur , Sulistiyowati Hari
Published: January 2025

This study discovered extended distribution of two woodpeckers, i.e., the Rufous Woodpecker (Micropternus brachyurus) and the Laced Woodpecker (Picus vittatus) in Meru Betiri National Park, East Java. The records of M. brachyurus were observed three times in Bandealit Resort (9 December 2021, 12 February 2022, and 20 April 2022) and once in Baban Resort on 9 September 2023. These record areas were around the first record area in secondary forest and the edge of plantations (Albizia, Cocos, and Ochroma) that also bordered the Bandealit road. The second record found a single individual foraging in Mangifera indica. The record of P. vittatus was observed once at Bandealit Resort on 11 February 2024. This species perched on Cocos nucifera, Mangifera indica, and Tectona grandis. Referring to altitude distribution, P. vittatus was only recorded at an altitude of 78 m asl., while M. brachyurus was more variable in the range of 79–651 m asl. These findings provide an essential update for the bird checklist in Meru Betiri National Park, particularly in the last 10 years ago.
Luonnon monimuotoisuudesta raportointi metsäteollisuudessa – faktoja, arvoja ja toimenpiteitä
Authors:   Jyväskylän yliopisto, Jyväskylän yliopiston kauppakorkeakoulu, Jyväskylä, Mäkelä Marileena ,   Jyväskylän yliopisto, JYU.Wisdom Resurssiviisausyhteisö, Jyväskylä, Halme Panu
Published: January 2025

Metsäluonnon monimuotoisuus vähenee maailmanlaajuisesti. Syinä ovat pääosin metsäkato ja luonnontilaisten metsien muuttaminen eri tavoin käsitellyiksi talousmetsiksi. Metsäteollisuus on metsien monimuotoisuuskadon säätelyssä merkittävässä roolissa. Yksi tapa yrityksille kuvata työtään luonnon monimuotoisuuden ylläpitämiseksi on raportointi vastuullisuusraporteissa. Luonnon monimuotoisuuden käsittelyä vastuullisuusraporteissa on tutkittu vain vähän. Suomessa metsäteollisuusyritykset olivat ensimmäisten yritysten joukossa julkaistessaan tällaisia raportteja 1990-luvulla. Me tutkimme, miten luonnon monimuotoisuuden suojelusta raportoidaan suomalaisten metsäteollisuusyritysten vastuullisuusraporteissa vuosien 1998–2021 aikana. Työmme aineistona on kolmen suomalaisen metsäteollisuusyrityksen (Stora Enso, UPM ja Metsä Board) vastuullisuusraportit vuosilta 1998–2021. Tutkimusmenetelmänämme on laadullinen sisällönanalyysi. Tuloksemme osoittavat, että yritykset raportoivat luonnon monimuotoisuudesta vuodesta 1998 lähtien, vaikkakin raportoinnissa on ollut vaihtelua eri vuosina ja eri yritysten välillä. Sisällöllisesti yritykset raportoivat seitsemästä teemasta, jotka ovat sanasto, GRI- (Global Reporting Initiative) ja SDG- (Sustainable Development Goals) raportointi, riskit, tavoitteet, faktat, arvot sekä toimenpiteet ja toimijuus. Tutkimuksemme osoittaa, että vaikka yritykset raportoivat paljon käytännön toimista luonnon monimuotoisuuden turvaamiseksi, raportoinnissa korostuu myös arvopuhe. Havaitsimme myös, että luonnon monimuotoisuudesta raportoinnissa on varsin positiivinen sävy.
Prevalence of plasmid-mediated Ampicillinase C genes in some Gram-negative ESKAPEE bacteria isolated from tertiary hospitals in southwest Nigeria
Authors: Adebiyi Ini , Balogun Saka
Published: January 2025

Background: Globally, hospital-acquired infections caused by multidrug resistant Gram-negative ESKAPEE pathogens has the highest probability of death. ESKAPEE bacteria may carry plasmids harbouring several resistance genes that code for β-lactamase enzyme like AmpC, which can be easily disseminated among bacteria.
Method: Two hundred and twenty-six bacterial isolates of
Klebsiella pneumoniae, Acinetobacter baumannii and
Eschericia coli were obtained from clinical samples of in-patients from three tertiary hospitals in Southwest Nigeria (University College Hospital, Ibadan, Federal Medical Centre, Abeokuta and Obafemi Awolowo University Teaching Hospital, Ile-Ife). Isolates were identified using Analytical Profile Index (API) Kit (BioMerieux). Antibiotic susceptibility testing was done using the Kirby Bauer disc diffusion method. Production of Amp-C was phenotypically confirmed using Three-dimensional extract tests. Resistance genes were detected using Polymerase Chain Reaction.
Result: Most (91.5%) of the isolates were multidrug resistant. Prevalence of phenotypic producers of AmpC was 19.9% while detection rates for AmpC genes was 3.5%, Phenotypic prevalence by isolates was
E. coli (16.5%),
Klebsiella pneumoniae (24.4%) and
Acinetobacter baumannii (28.6%). The most predominant gene was blaFOX (62.5%). Wound samples from surgical wards had the highest (15.6%) prevalence of AmpC phenotypes. The antibiotics with least (48.3%) and highest (97.2%) resistance were Meropenem and Ampicillin respectively. AmpC producing
Acinetobacter baumannii showed 100% resistance to Meropenem. Majority of the AmpC (95%) isolates were resistant to Ciprofloxacin and third generation Cephalosporins.
Conclusion: There is high prevalence of AmpC beta-lactamase-producing Gram-negative bacteria in hospitalized patients with possibility of dissemination among hospitalized patients in tertiary healthcare facilities in Southwest Nigeria.
PENSAMENTO CRÍTICO NAS ATIVIDADES DE ENSINO DA SEXUALIDADE EM LIVROS DIDÁTICOS DO OITAVO ANO
Authors: Cabral Vieira Milene Carolina , Emmel Rúbia
Published: January 2025

A educação sexual no ambiente escolar tem como uma de suas finalidades esclarecer as questões que rodeiam os jovens, a fim de construir com eles, um espaço livre de julgamentos e aberto ao diálogo. Esta pesquisa traz resultados da análise de seis livros didáticos (LDs), o potencial pedagógico de estratégias de ensino, em relação à promoção e desenvolvimento do Pensamento Crítico (PC). Essa pesquisa pretende perceber se os LDs promovem ou possuem potencial para promover o PC em Ciências, nas atividades de Educação Sexual. Trata-se de um estudo documental de abordagem qualitativa; a análise de conteúdo, os dados foram feitos pelas estratégias de ensino presentes nos seis LDs, através das estratégias, surgiram três categorias a priori: I- Informativas; II- Exploratórias e III- Crítica/Reflexiva. Após a pesquisa observaram-se diferentes padrões nos seis livros, sendo o LD6 o que menos oferece estratégias de ensino.
DIÁLOGOS SOBRE GÊNERO E MATEMÁTICA NA FORMAÇÃO INICIAL DE PEDAGOGAS/OS
Authors: Murback Maggioni Cássia Edmara , Freire França Fabiane
Published: January 2025

O objetivo deste texto consiste em analisar contribuições de uma ação formativa dialógica sobre gênero e matemática na formação inicial de Pedagogas/os. De caráter qualitativa, a coleta de dados teve como fonte de produção as discussões produzidas durante instituição e desenvolvimento de uma formação na modalidade de círculo dialógico, com acadêmicas de um curso de Pedagogia. Os dados foram transcritos e tratados a partir de eixos de discussão e, de modo geral, apresentam indícios de que as participantes puderam (re)pensar experiências sexistas e problematizar situações normalizada e reproduzidas pela sociedade patriarcal e classista. Indicam, ainda, que repensar de forma dialógica é fundamental para que futuras professoras não reproduzam a exclusão de meninas e mulheres nas aulas de matemática, ao contrário, se comprometam com uma educação matemática equitativa em gênero. Isto é possível, quando as participantes examinam diferentes vivências, trajetórias e perspectivas e confrontam a partir de textos científicos e históricos.
A ESCREVIVÊNCIA DE CONCEIÇÃO EVARISTO NO ENSINO DE CIÊNCIAS
Authors: Nascimento Brenda Iolanda Silva do , Da Costa Fernanda Antunes Gomes
Published: January 2025

Este artigo discute como a leitura do conto “Mansões e Puxadinhos”, de Conceição Evaristo, no Ensino de Ciências pode promover uma discussão engajada sobre a Educação das Relações Étnico-Raciais. Inspirado na abordagem teórico-metodológica de Gabriele Rosenthal (2014) e em diálogo com os pensamentos de bell hooks (2020) e Paulo Freire (1989), analisamos como as práticas de leitura literária da Escrevivência influenciaram as discussões sobre meio ambiente e saúde. Os resultados revelam que a prática da leitura não apenas estabelece conexões entre os textos de Conceição Evaristo e o cotidiano das estudantes, mas também possibilita o desenvolvimento de uma comunidade de aprendizagem comprometida com a Educação das Relações Étnico-Raciais no Ensino de Ciências.
institucionalização de um órgão de “proteção” na primeira República brasileira
Authors: Azevedo Paulo de Almeida Helena
Published: January 2025

O presente trabalho se dedica a analisar a institucionalização do primeiro órgão governamental responsabilizado pela promoção da inserção gradual das populações indígenas ao corpo nacional, durante a Primeira República brasileira. O então Serviço de Proteção ao Índio e Localização de Trabalhadores Nacionais (SPILTN) (criado em 1910) visava a identificação de povos indígenas e eventual reestruturação social de suas sociedades em prol da invisibilização de suas culturas e, posterior, realocação de suas populações como o texto propõe provar. O trabalho parte de um diálogo com as pesquisas de Manuela Carneiro da Cunha, Gersem Baniwa, Casé Angatu e Antônio Carlos de Souza Lima, para análise dos decretos que institucionalizaram o órgão, assim como o então Ministério da Agricultura e Serviço de Inspeção Agrícola.
La tutela colectiva en materia de consumo en España. Estado actual y líneas de reforma
Authors: Sanjurjo Ríos Eva Isabel
Published: January 2025

La presente obra versa sobre las acciones colectivas en materia de consumo en el ordenamiento español, desde el punto de vista del Derecho Procesal, con motivo de la reforma procesal que deberá realizarse fruto de la transposición a nuestro ordenamiento de la relevante Directiva (UE) 2020/1828 sobre la materia, y que conllevará importantes y novedosos cambios en la sustanciación procesal de este tipo de litigios.

En este sentido, el trabajo se divide en dos partes. En la primera de ellas, se efectúa el análisis jurídico de las especialidades procesales previstas en el texto vigente de la Ley de Enjuiciamiento Civil, con objeto de comprender los problemas que su aplicación práctica suscita ante los juzgados y tribunales y así poder realizar propuestas de reforma que impliquen una efectiva y real protección de los derechos e intereses de los consumidores y usuarios.

En la segunda parte del trabajo, se realiza un estudio jurídico y crítico sobre el Proyecto de Ley Orgánica de acciones colectivas para la protección y defensa de los derechos e intereses de los consumidores y usuarios, presentado para su tramitación parlamentaria en el mes de marzo de 2024. Dicho Proyecto, en el terreno práctico, implica renovar por completo la hasta entonces regulación procesal de la tutela colectiva de consumo en nuestro país: desde su configuración legal como un proceso especial, hasta la ampliación de su ámbito de aplicación y una tramitación procedimental distinta en función de la naturaleza de acción colectiva interpuesta, en donde la figura del juez pasa a tener un papel predominante por la concesión y reconocimiento de amplios poderes y facultades que exceden de su función tradicional de la dirección formal del proceso.

Eva Isabel Sanjurjo Ríos es Profesora Contratada Doctora de Derecho Procesal y Doctora por la Universidad de León con Premio Extraordinario. Cuenta con una dilatada trayectoria investigadora, con la publicación de numerosos artículos y capítulos de libro, además de tres monografías, destacando sus aportaciones en materia de prueba y arbitraje principalmente. Ha participado en varios proyectos de investigación y es miembro del Grupo de Innovación Docente del Área de Derecho Procesal de la Universidad de León. Fuera del ámbito universitario, ha sido Magistrada Suplente de la Audiencia Provincial de León y de la de Palencia durante ocho años, además de ser socia fundadora de la Asociación para el Fomento del Arbitraje de Castilla y León.