bluuebunny/crossref_metadata_2025 huggingface dataset:
Case report: Pulse cyclophosphamide for treatment of multi-agent-refractory hepatic graft-versus-host disease
Authors: Cai Yijun , Ali Amir , Filler Elan , Bayati Rua , Toma Tanjia , Zaki Omar , Yaghmour George , Ladha Abdullah , Woan Karrune , Tam Eric , Chaudhary Preet M.
Published: February 2024

Graft-versus-host disease (GVHD) is a common complication in patients receiving allogeneic hematopoietic stem cell transplantation (HSCT). GVHD is characterized as either acute or chronic based on symptomatology and histopathological findings. Despite advancements in disease-targeting therapeutics, steroid-refractory GVHD remains a significant contributor to mortality in HSCT recipients, highlighting the gaps in our understanding of its pathophysiology and treatment strategies. We present the case of a 46-year-old woman diagnosed with acute undifferentiated leukemia, who exhibited persistently elevated levels of serum total bilirubin (T.Bili), alkaline phosphatase (ALP), and liver function tests (LFTs) beginning on [day +201] post-haploidentical peripheral blood stem cell (PBSC) transplantation. The patient received fludarabine/total body irradiation (Flu/TBI) as a myeloablative conditioning regimen and post-transplant cyclophosphamide/tacrolimus/mycophenolate mofetil (PTCy/Tac/MMF) as GVHD prophylaxis. A liver biopsy confirmed the diagnosis of GVHD, while other possible etiologies were excluded by corresponding tests. Initial treatment with prednisone and tacrolimus, and the later addition of ruxolitinib, all showed poor response indicated by worsening T.Bili, ALP, and LFTs at the same time. Based on a multidisciplinary comprehensive assessment, we decided to administer 1,000 mg/m2 (1,600 mg) of cyclophosphamide (“pulse Cy”), which resulted in a dramatic improvement in T.Bili and transaminases starting from the very next day. A durable response to pulse cyclophosphamide was observed, as all indicators normalized (“complete response”) within 55 days without relapses. The patient remains in good health with no recurrence of hepatic GVHD. To our knowledge, this is the first case in which Grade IV hepatic GVHD, refractory to multiple agents including steroids, tacrolimus, and ruxolitinib, demonstrated a complete response to pulse cyclophosphamide. The success highlights the potential therapeutic role of cyclophosphamide, a potent and cost-effective chemotherapy agent, in treating multi-agent-refractory GVHD. Large-scale clinical trials are warranted to validate its efficacy in this setting.
Sex differences in cardiometabolic risk factors and in response to lifestyle intervention in prepubertal and pubertal subjects with obesity
Authors: Gilardini Luisa , Croci Marina , Cavaggioni Luca , Pasqualinotto Lucia , Bertoli Simona
Published: February 2024

Objectives

Childhood obesity is a growing health problem and requires a tailored treatment. This study explored the sex differences in cardiovascular risk factors in children/adolescents with obesity and in response to a weight loss intervention.

Methods

Five hundred and thirty-three children/adolescents with obesity and their parents underwent to a 3-months lifestyle intervention program. Tanner criteria were used to assess the pubertal stage. Before and after 3 months, anthropometric measurements, blood pressure (BP), and biochemical measurements were assessed.

Results

Four hundred and forty five participants completed the treatment (age 12.4 ± 2.7 years, males 45.8%, prepubertal 29.2%, BMI z score 2.3 ± 0.2). In comparison to boys, prepubertal girls had higher values of BMI z score (2.4 ± 02 vs. 2.3 ± 0.2, p < 0.05), waist circumference z score (2.2 ± 0.3 vs. 2.0 ± 0.3, p < 0.05), HOMA-IR [2.9 (2.1–4.9) vs. 2.3(1.5–3.6), p < 0.01], prevalence of hypertransaminasemia (41.3% vs. 17.7%, p < 0.05) and lower levels of HDL cholesterol (46.2 ± 9.8 vs. 51.2 ± 10.5 mg/dl, p < 0.05). In the pubertal stage, boys had worse cardiometabolic risk profile than girls, including unfavourable measure of systolic BP (z score: 0.6 ± 1.0 vs. 0.3 ± 1.0, p < 0.01), fasting glucose (87.2 ± 6.1 vs. 84.8 ± 7.7 mg/dl, p < 0.01), ALT (26.9 ± 21.5 vs. 20.2 ± 10.6 U/L, p < 0.001) and uric acid (6.1 ± 1.9 vs. 5.0 ± 1.0 mg/dl, p < 0.001). After the lifestyle intervention, changes in BMI z score (p < 0.05) were higher in pubertal boys than pubertal girls. The systolic blood pressure decrease was greater in pubertal boys than in their female counterpart (Δ systolic BP: −7.2 mmHg in boys vs. −3.6 mmHg in girls, p < 0.05; Δ systolic BP z score: −0.6 in boys vs. −0.3 in girls, p < 0.05). LDL cholesterol showed an improvement only in boys, and ALT in the whole group.

Conclusion

Our study showed that a short-term lifestyle intervention is more effective in reducing BMI z score and cardiovascular risk factors in pubertal boys than in their female counterparts. Further investigation is needed to deepen this gender difference, especially to develop a tailor-made intervention.
Taxonomic and functional shifts of gut microbiome in immunoglobulin A vasculitis children and their mothers
Authors: Liang Yijia , Zhao Changying , Zhao Lanlan , Sheng Dashuang , Chen Bin , Zhao Guoping , Wang Qinghua , Zhang Lei
Published: February 2024

Objectives

To examine the gut microbiota characteristics in children with immunoglobulin A vasculitis and their interrelationships with the host, while evaluate the vertical inheritance of microbiota in the development and progression of IgA vasculitis.

Methods

This study investigated the gut microbiome of 127 IgA vasculitis mother-child pairs and 62 matched healthy mother-child pairs, and compared the gut microbial composition of different groups. The pathway enrichment analysis evaluated potential gut microbiome-mediated pathways involved in the pathophysiology of IgA vasculitis. The Spearman correlation analysis illustrated the relationships between clinical variables and bacterial biomarkers.

Results

This study identified distinct intestinal microbiome in IgA vasculitis children compared to healthy children, and further pointed out the association in gut microbiota between IgA vasculitis children's and their mother's. The relative abundance of Megamonas and Lactobacillus in IgAV children was positively correlated with that in their mothers. The pathway enrichment analysis found microbial biosynthesis of vitamins and essential amino acids was upregulated in children with IgA vasculitis. Correlation analysis showed bacterial biomarkers were correlated with indicators of blood coagulation.

Conclusion

Children with IgA vasculitis have unique bacterial biomarkers and may affect coagulation function, and their gut microbiome was closely associated with that of their mothers. The observed association in gut microbiota between IgA vasculitis children and their mothers suggested a potential intergenerational influence of the maternal microbiota on the development or progression of IgA vasculitis in children.
Gestational diabetes and risk of perinatal depression in low- and middle-income countries: a meta-analysis
Authors: Jin Yuqing , Wu Chengkai , Chen Wanlin , Li Jingsong , Jiang Haiteng
Published: February 2024

Background

The relationship between gestational diabetes (GDM) and the risk of depression has been thoroughly investigated in high-income countries on their financial basis, while it is largely unexplored in low- and middle- income countries. This meta-analysis aims to assess how GDM influences the risk of perinatal depression by searching multiple electronic databases for studies measuring the odds ratios between them in low- and middle-income countries.

Methods

Two independent reviewers searched multiple electronic databases for studies that investigated GDM and perinatal mental disorders on August 31, 2023. Pooled odds ratios (ORs) and confidence intervals (CIs) were calculated using the random effect model. Subgroup analyses were further conducted based on the type of study design and country income level.

Results

In total, 16 observational studies met the inclusion criteria. Only the number of studies on depression (n=10) satisfied the conditions to conduct a meta-analysis, showing the relationship between mental illness and GDM has been overlooked in low- and middle-income countries. Evidence shows an elevated risk of perinatal depression in women with GDM (pooled OR 1.92; 95% CI 1.24, 2.97; 10 studies). The increased risk of perinatal depression in patients with GDM was not significantly different between cross-sectional and prospective design. Country income level is a significant factor that adversely influences the risk of perinatal depression in GDM patients.

Conclusion

Our findings suggested that women with GDM are vulnerable to perinatal depressive symptoms, and a deeper understanding of potential risk factors and mechanisms may help inform strategies aimed at prevention of exposure to these complications during pregnancy.
The causal effect of two occupational factors on osteoarthritis and rheumatoid arthritis: a Mendelian randomization study
Authors: Huang Jian
Published: February 2024

Background

Osteoarthritis (OA) and rheumatoid arthritis (RA) are two common types of arthritis. We conducted a two-sample Mendelian randomization (MR) study to estimate the causal effects of two common occupational factors—job involves heavy manual or physical work and job involves mainly walking or standing—on OA and RA in individuals of European ancestry.

Methods

Instruments were chosen from genome-wide association studies (GWASs) that identified independent single nucleotide polymorphisms (SNPs) robustly linked to job involves heavy manual or physical work (N = 263,615) as well as job involves mainly walking or standing (N = 263,556). Summary statistics for OA and RA were taken from the Integrative Epidemiology Unit (IEU) GWAS database; both discovery and replication GWAS datasets were considered. The primary analysis utilized the inverse variance weighted (IVW) MR method supplemented by various sensitivity MR analyses.

Results

In the IVW model, we found that genetically predicted job involves heavy manual or physical work was significantly associated with OA in both the discovery [odds ratio (OR) = 1.034, 95% confidence interval (CI): 1.016–1.053, P = 2.257 × 10−4] and replication (OR = 1.857, 95% CI: 1.223–2.822, P = 0.004) analyses. The causal associations were supported in diverse sensitivity analyses. MR analyses suggested no causal effect of genetically predicted job involves heavy manual or physical work on RA. Similarly, our data provided no evidence that genetically predicted job involves mainly walking or standing was related to OA and RA.

Conclusions

Our MR study suggests that job involves heavy manual or physical work is a risk factor for OA. It is of utmost importance to create preventive strategies aimed at reducing its impact on OA at such work sites.
A methodological approach to identify priority zones for monitoring and assessment of wild bee species under climate change
Authors: Acosta André Luis , dos Santos Charles Fernando , Imperatriz-Fonseca Vera Lucia , Oliveira Ricardo Caliari , Giannini Tereza Cristina
Published: February 2024

Climate change is affecting wild populations worldwide, and assessing the impacts on these populations is essential for effective conservation planning. The integration of advanced analytical techniques holds promise in furnishing detailed, spatially explicit information on climate change impacts on wild populations, providing fine-grained metrics on current environmental quality levels and trends of changes induced by estimated climate change scenarios. Here, we propose a framework that integrates three advanced approaches aiming to designate the most representative zones for long-term monitoring, considering different scenarios of climate change: Species Distribution Modeling (SDM), Geospatial Principal Component Analysis (GPCA) and Generalized Procrustes Analysis (GPA). We tested our framework with a climatically sensible Neotropical stingless bee species as study case,Melipona (Melikerria) fasciculataSmith, 1854. We used the SDM to determine the climatically persistent suitable areas for species, i.e. areas where the climate is suitable for species today and in all future scenarios considered. By using a GPCA as a zoning approach, we sliced the persistent suitable area into belts based on the variability of extremes and averages of meaningful climate variables. Subsequently, we measured, analyzed, and described the climatic variability and trends (toward future changes) in each belt by applying GPA approach. Our results showed that the framework adds significant analytical advantages for priority area selection for population monitoring. Most importantly, it allows a robust discrimination of areas where climate change will exert greater-to-lower impacts on the species. We showed that our results provide superior geospatial design, qualification, and quantification of climate change effects than currently used SDM-only approaches. These improvements increase assertiveness and precision in determining priority areas, reflecting in better decision-making for conservation and restoration.
Sleep health challenges among women: insomnia across the lifespan
Authors: Benge Elizabeth , Pavlova Milena , Javaheri Sogol
Published: February 2024

The presentation of sleep disorders varies widely among women and men, and sleep disorders among women are frequently subject to under- and delayed diagnosis. Insomnia is a complex sleep disorder with a multifactorial etiology, and women face many sex-specific sleep health challenges that may contribute to and influence the presence of insomnia symptoms across their lifespan. These include sex differences in neurobiology, hormonal variation during menstruation, pregnancy and menopause, increased prevalence of mood disorders, increased vulnerability to adverse socioeconomic factors, and gender discrimination, among other psychosocial stressors, particularly among women of racial-ethnic minority. As the medical community continues to recognize the significance of sleep as a vital pillar of overall wellbeing, the integration of sex-specific considerations in research, diagnosis, and treatment strategies is essential to optimizing sleep health for women.
Perceived determinants of food purchasing behavior applicable for behavioral change toward sustainable consumption
Authors: Pšurný Michal , Baláková Irena , Stávková Jana , Langr Alexandr
Published: February 2024

The paper deals with consumer behavior in the context of sustainable development of society. A questionnaire survey of 732 respondents was used to understand the determinants of food purchasing behavior toward sustainable consumption. The paper identifies the factors that the consumer determines in food purchasing as critical in terms of sustainable consumption and requiring behavioral change toward sustainability in terms of healthy lifestyle, reduction of food wastage, and conscious consumption. Respondents commented on 22 factors and the quantification of their impact on food waste and expressed the strength of opinion on sustainability issues. To evaluate the collected data, PCA factor analysis was used, which defines the importance of each factor by identifying artificial hypothetical variables, which are “Sustainability” and targeted education as appropriate tools for it, “Food usability,” which is a recommendation to producers by food quality, offering new types of food with longer shelf life, as well as “Pricing,” “Quality” and “Convenience.” The authors also sought to understand what measures they take in relation to waste and how they behave toward sustainable consumption and environmental protection. They created 14 content questions on this topic and by using factor analysis, 3 hypothetical variables were created, namely “Sustainable behavior” which expresses a healthy lifestyle, “Thoughtful purchase” which expresses a relationship with environmental protection before purchasing and “Zero waste” which means that the household tries to make additional use of food. Thus, it seeks a use for the food it cannot consume at a given time and creates a supply for other consumers. This behavior is a good prerequisite for achieving a change in consumption behavior. The influence of selected sociodemographic indicators on the frequency of wastage was also investigated using the χ-squared test. The influence of generation and number of children in the household on the frequency of wastage was demonstrated. The results of the analyses on the importance of individual factors and consumer behavior, especially of the young generation, argue for education on sustainable consumption.
Stenotrophomonas strain CD2 reduces cadmium accumulation in Brassica rapa L.
Authors: Fan Xia , Yuan Kai , Peng Qian , Lv Ruiling , Zheng Yongliang
Published: February 2024

Introduction

Cadmium (Cd) is a highly toxic heavy metal which contaminates agricultural soils and is easily absorbed by plants. Brassica rapa L. is one of the most popular vegetables in China and is known to accumulate Cd in its roots and aerial tissues.

Methods

A highly Cd-resistant bacterium (‘CD2’) was isolated and identified. Its ability to immobilize Cd(II) in medium was studied. Strain CD2 were added into Cd-polluted soil to ameliorate Cd accumulation in B. rapa. The underlying mechanisms of ‘CD2’ to reduce Cd accumulation in B. rapa. were analyzed by transcriptomics.

Results and discussion

Strain CD2 was classified as belonging to the genus Stenotrophomonas. Strain CD2 was found to be able to remove 0.1 mmol/L Cd(II) after 36 h by intracellular sequestration and by producing biofilm, exopolysaccharide, and H2S. When applied to Cd-contaminated soil, ‘CD2’ significantly increased the content of nonbioavailable Cd by 212.70%. Furthermore, ‘CD2’-inoculated B. rapa exhibited a 51.16% decrease in the Cd content of roots and a 55.56% decrease in the Cd content of aerial tissues. Transcriptome analysis identified 424 differentially expressed genes (DEGs) in the roots and 501 DEGs in the aerial tissues of uninoculated Cd-exposed plants. By comparison, 1107 DEGs were identified in the roots and 1721 DEGs were identified in the aerial tissues of ‘CD2’-inoculated Cd-exposed plants. In both treatment groups, genes related to vacuolar sequestration were upregulated, resulting in inhibited Cd transport. In addition, both catalase and glutathione transferase were induced in uninoculated plants, while the oxidative stress-related genes CPK and RBOH belonged to ‘plant-pathogen interactions’ were upregulated in ‘CD2’-inoculated plants. Moreover, inoculation with ‘CD2’ resulted in the enrichment of phenylpropane metabolism; cutin, suberine, and wax biosynthesis; and the AP2, Dof, WOX, Trihelix, B3, EIL, and M-type_MADS transcription factors; as well as the downregulation of zinc transporters and blue copper proteins. All of these changes likely contributed to the reduced Cd accumulation in ‘CD2’-inoculated B. rapa. The results of this study suggest that Stenotrophomonas sp. CD2 may prove to be a useful inoculant to prevent Cd accumulation in B. rapa.
Comparative Performance Analysis of Deep Learning, Classical, and Hybrid Time Series Models in Ecological Footprint Forecasting
Authors: Cihan Pınar
Published: February 2024

In a globalized world, factors such as increasing population, rising production rates, changing consumption habits, and continuous economic growth contribute significantly to climate change. Therefore, successfully forecasting the Ecological Footprint (EF) effectively indicates global sustainable development. Despite the significant role of the EF as one of the indicators of sustainable development, there is a gap in the literature regarding time series methods and forward-looking predictions. To address this gap, Ecological Footprint (EF) forecasting was performed using deep learning methods such as LSTMs, classical time series methods like ARIMA and Holt–Winters, and the developed hybrid ARIMA-SVR model. In the scope of the study, first, a spreadsheet was created using the total Ecological Footprint (EF) worldwide between 1961 and 2022, obtained from the Global Footprint Network database. Second, the forecasting performances of the ARIMA, Holt–Winters, LSTM, and the hybrid ARIMA-SVR models were compared using MAPE and RMSE metrics. Finally, the forecasting performances of the time series models were statistically validated through Wilcoxon Signed-Rank and Friedman tests. The study findings indicate that the proposed ARIMA (1,1,0) model demonstrated better performance with an average MAPE of 2.12%, compared to Holt–Winters (MAPE of 2.27%), LSTM (MAPE of 3.19%), and ARIMA-SVR (MAPE of 2.68%) methods in the test dataset. Additionally, it was observed that the ARIMA model forecasted the EF, which experienced a sudden decrease due to the COVID-19 lockdown, with a lower error compared to other models. These findings highlight the adaptability of the ARIMA model to variable and uncertain conditions.
Compliant-Control-Based Assisted Walking with Mobile Manipulator
Authors: Li Weihua , Li Pengpeng , Jin Lei , Xu Rongrong , Guo Junlong , Wang Jianfeng
Published: February 2024

In this paper, a new approach involving the use of a mobile manipulator to assist humans with mobility impairments to walk is proposed. First, in order to achieve flexible interaction between humans and mobile manipulators, we propose a variable admittance controller that can adaptively regulate the virtual mass and damping parameters based on the interaction forces and the human motion intention predicted using the fuzzy theory. Moreover, a feedforward velocity compensator based on a designed state observer is proposed to decrease the inertia resistance of the manipulator, effectively enhancing the compliance of the human–robot interaction. Then, the configuration of the mobile manipulator is optimized based on a null-space approach by considering the singularity, force capacity, and deformation induced by gravity. Finally, the proposed assisted walking approach for the mobile manipulator is implemented using the human–robot interaction controller and the null-space controller. The validity of the proposed controllers and the feasibility of assisted human walking are verified by conducting a set of tests involving different human volunteers.
Intermittent Stop-Move Motion Planning for Dual-Arm Tomato Harvesting Robot in Greenhouse Based on Deep Reinforcement Learning
Authors: Li Yajun , Feng Qingchun , Zhang Yifan , Peng Chuanlang , Zhao Chunjiang
Published: February 2024

Intermittent stop–move motion planning is essential for optimizing the efficiency of harvesting robots in greenhouse settings. Addressing issues like frequent stops, missed targets, and uneven task allocation, this study introduced a novel intermittent motion planning model using deep reinforcement learning for a dual-arm harvesting robot vehicle. Initially, the model gathered real-time coordinate data of target fruits on both sides of the robot, and projected these coordinates onto a two-dimensional map. Subsequently, the DDPG (Deep Deterministic Policy Gradient) algorithm was employed to generate parking node sequences for the robotic vehicle. A dynamic simulation environment, designed to mimic industrial greenhouse conditions, was developed to enhance the DDPG to generalize to real-world scenarios. Simulation results have indicated that the convergence performance of the DDPG model was improved by 19.82% and 33.66% compared to the SAC and TD3 models, respectively. In tomato greenhouse experiments, the model reduced vehicle parking frequency by 46.5% and 36.1% and decreased arm idleness by 42.9% and 33.9%, compared to grid-based and area division algorithms, without missing any targets. The average time required to generate planned paths was 6.9 ms. These findings demonstrate that the parking planning method proposed in this paper can effectively improve the overall harvesting efficiency and allocate tasks for a dual-arm harvesting robot in a more rational manner.
Repeatable Acoustic Vaporization of Coated Perfluorocarbon Bubbles for Micro-Actuation Inspired by Polypodium aureum
Authors: Jeong Se-Yun , Seo Han-Bok , Seo Myung-Hyun , Cho Jin-Woo , Kwon Seho , Son Gihun , Lee Seung-Yop
Published: February 2024

Polypodium aureum, a fern, possesses a specialized spore-releasing mechanism like a catapult induced by the quick expansion of vaporized bubbles. This study introduces lipid-coated perfluorocarbon droplets to enable repeatable vaporization–condensation cycles, inspired by the repeatable vaporization of Polypodium aureum. Lipid-perfluorocarbon droplets have been considered not to exhibit repeatable oscillations due to bubble collapse of the low surface tension of lipid layers. However, a single lipid-dodecafluoropentane droplet with a diameter of 9.17 µm shows expansion–contraction oscillations over 4000 cycles by changing lipid composition and applying a low-power 1.7 MHz ultrasound to induce the partial vaporization of the droplets. The optimal combinations of shell composition, droplet fabrication, and acoustic conditions can minimize the damage on shell structure and promote a quick recovery of damaged shell layers. The highly expanding oscillatory microbubbles provide a new direction for fuel-free micro- or nanobots, as well as biomedical applications of contrast agents and drug delivery.
Bio-Inspired Space Robotic Control Compared to Alternatives
Authors: Sands Timothy
Published: February 2024

Controlling robots in space with necessarily low material and structural stiffness is quite challenging at least in part due to the resulting very low structural resonant frequencies or natural vibration. The frequencies are sometimes so low that the very act of controlling the robot with medium or high bandwidth controllers leads to excitation of resonant vibrations in the robot appendages. Biomimetics or biomimicry emulates models, systems, and elements of nature for solving such complex problems. Recent seminal publications have re-introduced the viability of optimal command shaping, and one recent instantiation mimics baseball pitching to propose control of highly flexible space robots. The readership will find a perhaps dizzying array of thirteen decently performing alternatives in the literature but could be left bereft selecting a method(s) deemed to be best suited for a particular application. Bio-inspired control of space robotics is presented in a quite substantial (perhaps not comprehensive) comparison, and the conclusions of this study indicate the three top performing methods based on minimizing control effort (i.e., fuel) usage, tracking error mean, and tracking error deviation, where 96%, 119%, and 80% performance improvement, respectively, are achieved.
Numerical Simulation of the Transient Flow around the Combined Morphing Leading-Edge and Trailing-Edge Airfoil
Authors: Bashir Musavir , Negahban Mir Hossein , Botez Ruxandra Mihaela , Wong Tony
Published: February 2024

An integrated approach to active flow control is proposed by finding both the drooping leading edge and the morphing trailing edge for flow management. This strategy aims to manage flow separation control by utilizing the synergistic effects of both control mechanisms, which we call the combined morphing leading edge and trailing edge (CoMpLETE) technique. This design is inspired by a bionic porpoise nose and the flap movements of the cetacean species. The motion of this mechanism achieves a continuous, wave-like, variable airfoil camber. The dynamic motion of the airfoil’s upper and lower surface coordinates in response to unsteady conditions is achieved by combining the thickness-to-chord (t/c) distribution with the time-dependent camber line equation. A parameterization model was constructed to mimic the motion around the morphing airfoil at various deflection amplitudes at the stall angle of attack and morphing actuation start times. The mean properties and qualitative trends of the flow phenomena are captured by the transition SST (shear stress transport) model. The effectiveness of the dynamically morphing airfoil as a flow control approach is evaluated by obtaining flow field data, such as velocity streamlines, vorticity contours, and aerodynamic forces. Different cases are investigated for the CoMpLETE morphing airfoil, which evaluates the airfoil’s parameters, such as its morphing location, deflection amplitude, and morphing starting time. The morphing airfoil’s performance is analyzed to provide further insights into the dynamic lift and drag force variations at pre-defined deflection frequencies of 0.5 Hz, 1 Hz, and 2 Hz. The findings demonstrate that adjusting the airfoil camber reduces streamwise adverse pressure gradients, thus preventing significant flow separation. Although the trailing-edge deflection and its location along the chord influence the generation and separation of the leading-edge vortex (LEV), these results show that the combined effect of the morphing leading edge and trailing edge has the potential to mitigate flow separation. The morphing airfoil successfully contributes to the flow reattachment and significantly increases the maximum lift coefficient (cl,max)). This work also broadens its focus to investigate the aerodynamic effects of a dynamically morphing leading and trailing edge, which seamlessly transitions along the side edges. The aerodynamic performance analysis is investigated across varying morphing frequencies, amplitudes, and actuation times.
Catalytic Partial Oxidation of Methane to Methanol over Fe2O3/MWCNTs
Authors: Zhou Zhengqing , Zhang Yinghua , Huang Zhian , Liu Jia , Sang Jinguo , Luan Zuochun , Tian Wei , Gao Yukun , Zhang Xingyu , Ji Yucheng , Tang Tao
Published: February 2024

The catalytic partial oxidation of methane (CPOM) to methanol has been regarded as a promising approach for methane utilization, despite that the conversion remains a formidable challenge in the perspective of catalysts. A novel catalyst system of multi-wall carbon nanotubes (MWCNTs) that supported Fe2O3 with existing I2, consisting of non-noble metal and working in weak acid at an ambient temperature, was investigated for CPOM. MWCNTs supported the Fe2O3 catalyst, which was prepared by the impregnation method and characterized via HRTEM, XRD, XPS, FT-IR, and BET techniques. The characterization results reveal that, as a non-noble metal catalyst, the Fe2O3/MWCNTs catalyst had a good catalytic performance and stability in the CPOM. With the variation of reaction pressure and the dosage of Fe2O3/MWCNTs, the catalyst system obtained the highest methane conversion rate of 7.41% and methanol selectivity of 86.3%, which is analogous to that of the equivalently strong acid catalyst system. The I2-Fe2O3/MWCNTs catalyst system has great potential in the application of CPOM under mild, environmentally benign conditions, such as non-noble metal requirement, ambient temperature, and weak acid. The reaction mechanism was discussed.
“We Want to Talk about Death, Dying and Grief and to Learn about End-of-Life Care”—Lessons Learned from a Multi-Center Mixed-Methods Study on Last Aid Courses for Kids and Teens
Authors: Bollig Georg , Gräf Kirsti , Gruna Harry , Drexler Daniel , Pothmann Raymund
Published: February 2024

Background: Last Aid Courses (LAC) for adults have been established in 21 countries in Europe, Australia and America to improve the public discussion about death and dying and to empower people to participate in end-of-life care provision. In 2018, the first Last Aid Courses for kids and teens (LAC-KT) were introduced. The aim of the study was to explore the views and experiences of the course participants and Last Aid Course instructors on the LAC-KT. Methods: A mixed-methods approach was used. The views of the LAC-KT participants, aged 7 to 17 years, on the LAC-KT were collected using a questionnaire. In addition, the experiences of the Last Aid Course instructors were explored in focus group interviews. Results: The results show that 84% of the participants had experiences with death and dying and 91% found the LAC-KT helpful for everyone. The majority of the participants appreciate the opportunity to talk and learn about death, dying, grief and palliative care. Conclusions: The LAC-KT is feasible, very well accepted and a welcome opportunity for exchanging and obtaining information about dying, grief and palliative care. The findings of the study indicate that the LAC-KT should be offered to all interested children and teenagers and included in the school curriculum.
Inhibition of Glial Activation and Subsequent Reduction in White Matter Damage through Supplementation with a Combined Extract of Wheat Bran, Citrus Peel, and Jujube in a Rat Model of Vascular Dementia
Authors: Kim Ki Hong , Lim Sun-Ha , Hwang Jeong Hyun , Lee Jongwon
Published: February 2024

Vascular dementia (VaD) is the second most common type of dementia after Alzheimer’s disease. In our previous studies, we showed that wheat bran extract (WBE) reduced white matter damage in a rat VaD model and improved memory in a human clinical trial. However, starch gelatinization made the large-scale preparation of WBE difficult. To simplify the manufacturing process and increase efficacy, we attempted to find a decoction containing an optimum ratio of wheat bran, sliced citrus peel, and sliced jujube (WCJ). To find an optimal ratio, the cell survival of C6 (rat glioma) cultured under hypoxic conditions (1% O2) was measured, and apoptosis was assessed. To confirm the efficacies of the optimized WCJ for VaD, pupillary light reflex, white matter damage, and the activation of astrocytes and microglia were assessed in a rat model of bilateral common carotid artery occlusion (BCCAO) causing chronic hypoperfusion. Using a combination of both searching the literature and cell survival experiments, we chose 6:2:1 as the optimal ratio of wheat bran to sliced citrus peel to sliced jujube to prepare WCJ. We showed that phytic acid contained only in wheat bran can be used as an indicator component for the quality control of WCJ. We observed in vitro that the WCJ treatment improved cell survival by reducing apoptosis through an increase in the Bcl-2/Bax ratio. In the BCCAO experiments, the WCJ-supplemented diet prevented astrocytic and microglial activation, mitigated myelin damage in the corpus callosum and optic tract, and, consequently, improved pupillary light reflex at dosages over 100 mg/kg/day. The results suggest that the consumption of WCJ can prevent VaD by reducing white matter damage, and WCJ can be developed as a safe, herbal medicine to prevent VaD.
Topology Optimization and Efficiency Evaluation of Short-Fiber-Reinforced Composite Structures Considering Anisotropy
Authors: Kurkin Evgenii , Espinosa Barcenas Oscar Ulises , Kishov Evgenii , Lukyanov Oleg
Published: February 2024

The current study aims to develop a methodology for obtaining topology-optimal structures made of short fiber-reinforced polymers. Each iteration of topology optimization involves two consecutive steps: the first is a simulation of the injection molding process for obtaining the fiber orientation tensor, and the second is a structural analysis with anisotropic material properties. Accounting for the molding process during the internal iterations of topology optimization makes it possible to enhance the weight efficiency of structures—a crucial aspect, especially in aerospace. Anisotropy is considered through the fiber orientation tensor, which is modeled by solving the plastic molding equations for non-Newtonian fluids and then introduced as a variable in the stiffness matrix during the structural analysis. Structural analysis using a linear anisotropic material model was employed within the topology optimization. For verification, a non-linear elasto-plastic material model was used based on an exponential-and-linear hardening law. The evaluation of weight efficiency in structures composed of short-reinforced composite materials using a dimensionless criterion is addressed. Experimental verification was performed to confirm the validity of the developed methodology. The evidence illustrates that considering anisotropy leads to stiffer structures, and structural elements should be oriented in the direction of maximal stiffness. The load-carrying factor is expressed in terms of failure criteria. The presented multidisciplinary methodology can be used to improve the quality of the design of structures made of short fiber-reinforced composites (SFRC), where high stiffness, high strength, and minimum mass are the primary required structural characteristics.
Differential Diagnosis in the Management of Acute Respiratory Infections through Point-of-Care Rapid Testing in a Post-Pandemic Scenario in Latin America: Special Focus on COVID-19, Influenza, and Respiratory Syncytial Virus
Authors: Alvarez-Moreno Carlos Arturo , de Araújo Evaldo Stanislau Affonso , Baumeister Elsa , Nogales Crespo Katya A. , Kalergis Alexis M. , Muñoz Medina José Esteban , Tsukayama Pablo , Ugarte-Gil Cesar
Published: February 2024

This review provides a comprehensive summary of evidence to explore the role and value of differential diagnosis in the management of Acute Respiratory Infections (ARIs) through point-of-care (POC) rapid testing in a post-pandemic scenario, paying particular attention to coronavirus disease 2019 (COVID-19), influenza, and respiratory syncytial virus (RSV). The document builds on a review of literature and policies and a process of validation and feedback by a group of seven experts from Latin America (LATAM). Evidence was collected to understand scientific and policy perspectives on the differential diagnosis of ARIs and POC rapid testing, with a focus on seven countries: Argentina, Brazil, Chile, Colombia, Costa Rica, Mexico, and Peru. The evidence indicates that POC rapid testing can serve to improve ARI case management, epidemiological surveillance, research and innovation, and evidence-based decision-making. With multiple types of rapid tests available for POC, decisions regarding which tests to use require the consideration of the testing purpose, available resources, and test characteristics regarding accuracy, accessibility, affordability, and results turnaround time. Based on the understanding of the current situation, this document provides a set of recommendations for the implementation of POC rapid testing in LATAM, supporting decision-making and guiding efforts by a broad range of stakeholders.
Autoimmune Hepatitis: A Diagnostic and Therapeutic Overview
Authors: Mercado Lydia A. , Gil-Lopez Fernando , Chirila Razvan M. , Harnois Denise M.
Published: February 2024

Autoimmune hepatitis is an immune-mediated inflammatory condition of the liver of undetermined cause that affects both sexes, all ages, races, and ethnicities. Its clinical presentation can be very broad, from having an asymptomatic and silent course to presenting as acute hepatitis, cirrhosis, and acute liver failure potentially requiring liver transplantation. The diagnosis is based on histological abnormalities (interface hepatitis), characteristic clinical and laboratory findings (increased aspartate aminotransferase, alanine aminotransferase, and serum IgG concentration), and the presence of one or more characteristic autoantibodies. The large heterogeneity of these clinical, biochemical, and histological findings can sometimes make a timely and proper diagnosis a difficult task. Treatment seeks to achieve remission of the disease and prevent further progression of liver disease. First-line therapy includes high-dose corticosteroids, which are later tapered to decrease side effects, and azathioprine. In the presence of azathioprine intolerance or a poor response to the standard of care, second-line therapy needs to be considered, including mycophenolate mofetil. AIH remains a diagnostic and therapeutic challenge, and a further understanding of the pathophysiological pathways of the disease and the implementation of randomized controlled trials are needed.
On Enhancing the COVID-19 Certification System for the Digitally-Illiterate People Inclusion in the European Union
Authors: Hadasik Bartłomiej , Mach-Król Maria
Published: February 2024

The COVID-19 pandemic led to widespread restrictions globally, prompting governments to implement measures for containment. Vaccines, while aiding in reducing virus transmission, have also introduced the challenge of identifying vaccinated individuals for the purpose of easing restrictions. The European Union (EU) addressed this through the “digital COVID-19 certification” system, allowing citizens to travel within the EU based on their vaccination, recovery, or negative test status. However, the system’s digital format poses challenges for those who are not digitally proficient, such as seniors and those with low educational or socioeconomic status. This study aims to propose enhancements to the current system, considering the mobility needs of all citizens. The methodology involves reviewing literature on digital literacy, the digital divide, and information systems related to vaccination and certification. The paper presents straightforward recommendations to make the COVID-19 certificate more accessible to digitally excluded individuals. These proposals may serve as a valuable starting point for healthcare executives to evaluate and adapt the certification scheme to be inclusive of a broader range of stakeholders.
Development and Validation of a Compressible Reacting Gas-Dynamic Flow Solver for Supersonic Combustion
Authors: Gilmanov Anvar , Gokulakrishnan Ponnuthurai , Klassen Michael S.
Published: February 2024

An approach based on the OpenFOAM library has been developed to solve a high-speed, multicomponent mixture of a reacting, compressible flow. This work presents comprehensive validation of the newly developed solver, called compressibleCentralReactingFoam, with different supersonic flows, including shocks, expansion waves, and turbulence–combustion interaction. The comparisons of the simulation results with experimental and computational data confirm the fidelity of this solver for problems involving multicomponent high-speed reactive flows. The gas dynamics of turbulence–chemistry interaction are modeled using a partially stirred reactor formulation and provide promising results to better understand the complex physics involved in supersonic combustors. A time-scale analysis based on local Damköhler numbers reveals different regimes of turbulent combustion. In the core of the jet flow, the Damköhler number is relatively high, indicating that the reaction time scale is smaller than the turbulent mixing time scale. This means that the combustion is controlled by turbulent mixing. In the shear layer, where the heat release rate and the scalar dissipation rate have the highest value, the flame is stabilized due to finite rate chemistry with small Damköhler numbers and a limited fraction of fine structure. This solver allows three-dimensional gas dynamic simulation of high-speed multicomponent reactive flows relevant to practical combustion applications.
Fluctuation Relation for the Dissipative Flux: The Role of Dynamics, Correlations and Heat Baths
Authors: Lin Xubin , Rondoni Lamberto , Zhao Hong
Published: February 2024

The fluctuation relation stands as a fundamental result in nonequilibrium statistical physics. Its derivation, particularly in the stationary state, places stringent conditions on the physical systems of interest. On the other hand, numerical analyses usually do not directly reveal any specific connection with such physical properties. This study proposes an investigation of such a connection with the fundamental ingredients of the derivation of the fluctuation relation for the dissipation, which includes the decay of correlations, in the case of heat transport in one-dimensional systems. The role of the heat baths in connection with the system’s inherent properties is then highlighted. A crucial discovery of our research is that different lattice models obeying the steady-state fluctuation relation may do so through fundamentally different mechanisms, characterizing their intrinsic nature. Systems with normal heat conduction, such as the lattice ϕ4 model, comply with the theorem after surpassing a certain observational time window, irrespective of lattice size. In contrast, systems characterized by anomalous heat conduction, such as Fermi–Pasta–Ulam–Tsingou-β and harmonic oscillator chains, require extended observation periods for theoretical alignment, particularly as the lattice size increases. In these systems, the heat bath’s fluctuations significantly influence the entire lattice, linking the system’s fluctuations with those of the bath. Here, the current autocorrelation function allows us to discern the varying conditions under which different systems satisfy with the fluctuation relation. Our findings significantly expand the understanding of the stationary fluctuation relation and its broader implications in the field of nonequilibrium phenomena.
Reminiscences of Half a Century of Life in the World of Theoretical Physics
Authors: Tsallis Constantino
Published: February 2024

Selma Lagerlöf said that culture is what remains when one has forgotten everything we had learned. Without any warranty, through ongoing research tasks, that I will ever attain this high level of wisdom, I simply share here reminiscences that have played, during my life, an important role in my incursions in science, mainly in theoretical physics. I end by presenting some perspectives for future developments.
Comparison of Clinical Estimation and Stereophotogrammic Instrumented Imaging of Burn Scar Height and Volume
Authors: Bharadia Shyla Kajal , Gabriel Vincent
Published: February 2024

Descriptive clinical tools for characterizing burn scars are limited by between-user variability and unknown sensitivity to change over time. We previously described preclinical assessment of stereophotogrammetry as a valid measure of burn-related scars. Here, we compared the estimated vs. instrumented measurements of maximum height and total positive volume of 26 burn scars. The burn scars were imaged with the QuantifiCare LifeViz Micro 3D camera. Three experienced wound care therapists first estimated, then measured using 3D Track software, the imaged scars’ height and volume. Two-factor analysis without replication was performed to calculate intraclass correlation coefficients (ICCs) between assessors’ estimated scar height and volume, and measured height and volume. Two-sided Wilcoxon tests were performed comparing the mean estimated height and volume with the estimated and measured outputs. The estimated scar height’s ICC was 0.595, and for volume, it was 0.531. The measured scar height’s ICC was 0.933 and for volume, it was 0.890. The estimated and measured volume were significantly different (z = −2.87, p = 0.041), while the estimated and measured height were not (z = −1.39, p = 0.161). Stereophotogrammic measurement of scar height and volume is more reliable than clinical photograph assessment. Stereophotogrammetry should be utilized when assessing burn scar height and volume, rather than subjective estimates from clinical scar tools.