bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengukuran lipoprotein-associated phospholipase A2 sebagai alat diagnostik dan penentu prognosis
Authors: Yardhika Ardelia , Alamanda Monik , Konny Lisye
Published: December 2022

Pendahuluan: Penyakit kardiovaskular merupakan salah satu penyakit tidak menular utama dan menyebabkan 17,5 juta kematian setiap tahunnya. Pengukuran kadar biomarker inflamasi Lp-PLA2 dapat dilakukan untuk mengetahui risiko pembentukan aterosklerosis. Lp-PLA2 merupakan enzim spesifik inflamasi vaskular dan tidak dipengaruhi oleh inflamasi sistemik. Bahan dan Materi: Telaah sistematik dilakukan pada situs pencarian ProQuest, EBSCO, dan Google Scholar. Didapatkan 259 artikel jurnal yang kemudian dieksklusi menjadi 22 artikel yang kemudian dianalisis. Hasil dan Pembahasan: Deteksi pasien terkena aterosklerosis menggunakan kadar kolesterol dan CRP tidaklah akurat dan spesifik. Lp-PLA2 merupakan enzim yang spesifik berada pada pembuluh darah dan dapat menjadi biomarker baru untuk menentukan ada atau tidaknya aterosklerosis. Pengukuran Lp-PLA2 dapat dilakukan dengan mengukur massa dan aktivitas Lp-PLA2. Kesimpulan: Lp-PLA2 merupakan marker yang paling baik dibandingkan marker lainnya seperti kolesterol dan CRP untuk melihat risiko penyakit jantung koroner dan iskemik akibat aterosklerosis.
Status nutrisi ibu hamil di wilayah kerja puskesmas Karangasem I Kabupaten Karangasem Bali 2015
Authors: Suardana I Made
Published: December 2022

Peningkatan berat badan pada ibu hamil merupakan salah satu indikator status nitrisi pada ibu hamil. Peningkatan berat badan yang kurang menunjukkan status nutrisi rendah pada ibu hamil, yang berdampak terhadap lahirnya bayi dengan berat badan yang rendah (BBLR). Oleh karena itu, penelitian ini ditujukan untuk mengetahui prevalensi status nutrisi ibu hamil dan karakteristik peningkatan berat badan ibu hamil di wilayah kerja Puskesmas Karangasem I. Penelitian ini merupakan penelitian deskriptif cross-sectional pada 45 ibu hamil di seluruh desa yang ada di wilayah kerja Puskesmas Karangasem I, yang dipilih dengan metode consecutive sampling. Variabel yang diteliti adalah status nutrisi, peningkatan berat badan, lingkar lengan atas (LILA), umur ibu, jumlah paritas, jarak kehamilan, frekuensi ANC, status ekonomi dan tingkat pendidikan ibu. Data dikumpulkan dengan metode wawancara terstruktur serta observasi. Berat badan ibu hamil diukur dengan timbangan injak dan LILA diukur dengan menggunakan meteran, data yang diperoleh dianalisis secara deskriptifi. Hasil penelitian menunjukkan sebesar 40,0% ibu hamil dengan peningkatan berat badan yang tidak normal sesuai dengan umur kehamilan. Berdasarkan LILA didapatkan sebesar 8,9% ibu hamil mengalami kekurangan energi kronis (KEK). Berdasarkan hasil pengukuran LILA didapatkan bahwa persentase ibu yang mengalami KEK lebih tinggi pada kelompok umur yang beresiko jika dibandingkan dengan kelompok umur yang tidak beresiko (11,1% : 8,3%). Ibu yang memiliki jarak kehamilan < 2 tahun lebih banyak mengalami KEK dibandingkan dengan yang memiliki jarak kehamilan â‰¥2 tahun (10,5% : 7,6 % ). Dari status ekonomi, KEK hanya terjadi pada ibu dengan status ekonomi rendah(11,1%), begitu pula pada tingkat pendidikan, KEK hanya terjadi pada ibu dengan tingkat pendidikan rendah(23,5%).
Karakteristik kasus kecelakaan di UPT kesmas Tegallalang I Kabupaten Gianyar Bali 2014
Authors: Candra Pranadhita Ida Bagus
Published: December 2022

Accidents are unpredictable and can not be anticipated by someone. Generally, accidents can be divided into traffic accidents and occupational accidents. In Indonesia, the mortality rate of traffic accidents are 120 people per day. Meanwhile the current global mortality rate reached 1.24 million per year. In Bali, by the Central Bureau of Statistics of Bali Province in 2013 occurred approximately 2166 cases of accidents with fatalities reached 578 victims and material losses of approximately four billion rupiahs. In 2013, accidents placed at first rank of 10 major diseases by 5579 the number of cases with details of 210 cases of occupational accidents and 5369 cases of traffic accidents. No studies have argued about the characteristics of the cases of accidents, so UPT Kesmas Tegallalang I readiness in handling of accident cases is unknown. This study was descriptive quantitative approached using cross-sectional methode. This research was conducted in the region of UPT Kesmas Tegallalang I on December 2014 â€“ Januray 2015. Population in this study were all accidentâ€™s victims were brought to Emergency Room of UPT Kesmas Tegallalang I. The sampling technique used was total sampling with a sample of 1131 people. The instrument used wassecondary data of pattientâ€™s register were brought to Emergency Room of UPT Kesmas Tegallalang I at 2014. Data analysis techniques with descriptive which presented in narrative with table or chart. Characteristic of patients most of this research on male sex (64.8 %), group of young adults age ( 30.8 % ), originated from the village of tegallalang (39.9 %) , with the diagnosis stab wound (28.8 %), did not have the medical intervention (50.4 %) , received antibiotics amoxicilin (67.7 %) .The number of the most cases is in November (104 cases) , the number of cases referred is highest in january (8 cases) .The use of amoxicilin is highest in November , the use of erythomicin is highest in December , the use of anti rabies vaccine isÂ  highest in february (13 cases). The emergency department at puskesmas requires the readiness of good in providing services to patients accident victims.
Ekstrak etanol buah naga merah (Hylocereus polyrhizus) memperbaiki profil lipid tikus (Rattus Norvegicus) wistar jantan dislipidemia sama efektif dengan statin
Authors: Sharan Sharan
Published: December 2022

Dyslipidemia is one of the risk factor causing atherosclerosis, which is the main cause of cardiovascular disease and later can leads to death. Proper balanced diet and exercise are the main way to lower down lipid level. If the nonpharmacolgy interventions doesnâ€™t give satisfactory result, the use ofÂ  medicine such as statin, which is the gold standard for dyslipidemia can be applied. It is also important to find outÂ  the effects of nature herbs such as red dragon fruit on dyslipidemia. Dragon fruit contains anthocyanin, which is one type of flavonoid found in many dragon fruits that can improve dislipidemic. The aim of this thesis is to prove the effect of red dragon fruit in improving serum lipid profile (total cholesterol, triglycerides, LDL cholesterol and HDL cholesterol) in male dyslipidemic rats as effective as Statin.This study was purely experimentalÂ  research by using pre-posttest control group design. This study used 24 male white rats (albino rat) with dislipidemia as a sample. For 28 days the entire male rats were given high-cholesterol diet. The male rats were randomly divided into 3 groups, each group consistedÂ  ofÂ  eight rats. The First group were given a standard diet and placebo in the form of distilled water. The Second group were given a standard diet and dragon fruit extractÂ  120 mg/ 200g body weight. The ThirdÂ  group were given a standard dietÂ  and statin 10mg/200g body weight. All the groups were given treatment once a day for 28 days.Â Result showed that there was significant reduction in lipid level in second and third group, total cholesterol level reduction of each 73,41mg/dl and 94mg/dl (p<0,05), Triglyceride level reduction of 25.38mg/dl and 53.13mg/dl (p<0,05), LDL level reduction of 20.39mg/dl and 47.96mg/dl (p<0.05), and increase in HDL level of 12.36mg/dl and 32.38mg/dl as compared to first group which was treated with distilled water.It can be concluded that dragon fruit extract and statins are equally effective to improved lipid profile level in male dyslipidemic witsar rats , but statin potency is more powerful than red dragon fruit extract in improving the lipid profile.
Hubungan antara kualitas tidur dan perubahan berat badan pada mahasiswa perempuan program studi kedokteran umum tahun pertama di universitas udayana 2014
Authors: Tasya Nur Syahirah , Tirtayasa Ketut
Published: December 2022

Peningkatan berat badan berkaitan dengan ketidakseimbangan kondisi emosional dan fisiologi seseorang. Banyak faktor yang berkontribusi terhadap terjadinya ketidakseimbangan ini salah satunya adalah kualitas tidur yang buruk. Tujuan dari penelitian ini adalah untuk menentukan hubungan antara perubahan kualitas tidur dan perubahan berat badan pada Mahasiswa Perempuan Program Studi Kedokteran Umum Tahun Pertama di Universitas Udayana. Penelitian ini adalah suatu kohort analitik dengan besar sampel 33 orang, menggunakan teknik simple random sampling. Subyek penelitian adalah Mahasiswa Perempuan Prodi Kedokteran Umum Tahun Pertama di Universitas Udayana. Kuesioner Pittsburgh Sleep Quality Index (PSQI) digunakan untuk penilaian subjektif kualitas tidur. Berat badan diukur dengan timbangan â€˜KRISâ€™ dengan akurasi 0,1 kg dan perubahan berat badan dihitung dengan mengukur berat badan subjek di awal dan akhir periode enam bulan. Data yang dikumpulkan kemudian dianalisis dengan uji korelasi Pearson. Untuk kualitas tidur, perbedaan skor minimum dan maksimum adalah -4,00 dan 11,00. Sedangkan nilai rata-rata yang diperoleh adalah 2,57 Â± 4,40. Perubahan berat badan minimum dan maksimum adalah -2,10 dan 7,00 kg. Sedangkan nilai rata-rata yang diperoleh untuk variabel ini adalah 2,33 Â± 2,44. Hanya terdapat hubungan yang lemah antara kualitas hidup berdasarkan PSQI dan perubahan berat badan (r = 0,130) namun tidak signifikan (p= 0,472). Â Disimpulkan bahwa tidak terdapat hubungan antara kualitas tidur dan perubahan berat badan pada populasi yang diwakili oleh sampel.
Gambaran tingkat kepatuhan ibu hamil mengkonsumsi tablet besi di wilayah kerja puskesmas Sidemen tahun 2015
Authors: Sivanganam Sinthu , Westa Wayan
Published: December 2022

In Indonesia, prevention of anemia in pregnant women by providing as many as 90 tablets Fe supplements during pregnancy. However many pregnant women do not comply with this recommendation because of various reasons so anemia prevalence is still high. One of the factors that influence is the role of health care. This is important both as a source of information reliable as well as providers of medical services for prevention anemia in pregnant women. Detailed information about health services so. Pregnant women do not understand the dangers and the importance of giving iron tablets most of them assume that consuming Fe tablets can cause side effects so people tend to reject. This study was a Descriptive cross sectional to identify the level of compliance of pregnant women taking iron tablets knowing picture and information from health professionals about anemia and provision of iron tablets in the village of Sidemen. The results obtained from 50 respondents surveyed as many as 18 people (36%) out of 50 pregnant women in Sidemen village, Karangasem categorized obedient in consuming iron tablets, while as many as 32 people (64%) categorized as non-compliant
Karakteristik profil jerawat berdasarkan indeks glikemik makanan pada mahasiswa semester III fakultas kedokteran Universitas Udayana tahun 2014
Authors: Naravenah Mohana , Suryawati Nyoman
Published: December 2022

Jerawat adalah kondisi kulit yang paling umum ditemukan di antara remaja, yang mempengaruhi sekitar 85% dari remaja membawa banyak faktor pemicu. Penelitian ini mengeksplorasi tentang indeks glikemik makanan di kalangan mahasiswa yang menderita jerawat yang dapat menjadi salah satu faktor pemicu jerawat. Desain studi yang dipilih untuk penelitian ini adalah penelitian deskriptif dengan 210 siswa sebagai responden dari Semester 3 di Fakultas Kedokteran Universitas Udayana. Kuesioner diberikan untuk menjawab semua responden. Untuk menentukan indeks glikemik makanan dari masing-masing responden, daftar makanan dimasukkan dalam kuesioner dengan ukuran porsi dan frekuensi asupan makanan. Di antara semua 210 responden hanya 77 responden menderita jerawat dan mayoritas dari mereka adalah 49 perempuan. Usia puncak responden yang menderita jerawat adalah responden yang berusia 18 sampai 20 tahun. Dari segi faktor indeks glikemik makanan, Â 34 responden yang menderita jerawat memiliki indeks glikemik makanan yang tinggi diikuti oleh 32 responden dikategorikan sebagai memiliki medium indeks glikemik makanan dan 11 responden memiliki indeks glikemik makanan yang rendah. Demikian, dapat disimpulkan bahwa indeks makanan glikemik tinggi dianggap sebagai salah satu faktor pemicu untuk menyebabkan jerawat antara remaja.
Gambaran perilaku pemakaian kontrasepsi pasca persalinan pada wanita usia subur di desa gelgel, Klungkung-Bali
Authors: Jesicca Sharon , Aryani Putu
Published: December 2022

Kontrasepsi pasca persalinan merupakan pemasangan kontrasepsi dalam jangka waktu 42 hari setelah melahirkan untuk mencegah kehamilan dengan jarak dekat. Usia subur seorang wanita biasanya antara 15-49 tahun, untuk mengatur jumlah kelahiran atau menjarangkan kelahiran, wanita/pasangan ini lebih diprioritas untuk menggunakan alat/cara KB. Tujuan dari penelitian ini adalah untuk mengetahui gambaran perilaku pemakaian kontrasepsi pasca persalinan pada wanita usia subur di Desa Gelgel wilayah kerja Puskesmas Klungkung I. Penelitian ini menggunakan rancangan penelitian deskriptif, dengan metode cross-sectional. Pengambilan sampel dilakukan dengan metode total sampling sebanyak 46 orang sebagai sampel dalam penelitian ini. Hasil penelitian ini menunjukkan sebagian besar sudah pernah menggunakan kontrasepsi yaitu 32 orang (69,6%), wanita usia subur yang memiliki sikap baik banyak yang memilih untuk menggunakan kontrasepsi pasca persalinan (32.1%).Â
Kualitas tidur pada geriatri di panti jompo tresna wana seraya, Denpasar-Bali
Authors: Kumar Vilasinee Ari Hara , Ratep Nyoman
Published: December 2022

Tidur adalah masalah kesehatan yang paling umum ditemukan pada geriatri, yang mempengaruhi sekitar 85% dari geriatri. Rancangan penelitian yang dipilih untuk penelitian ini adalah penelitian deskriptif dengan 30 sampel dari geriatri yang tinggal di Panti Jompo Tresna Wana Seraya sebagai responden.Â Kuesioner diberikan untuk dijawab oleh semua 30 responden.Â Kuesioner yang digunakan adalah Pittsburgh Sleep Quality Index (PSQI). Dari keseluruhan 30 responden hanya 19 responden (63.3%) yang memiliki kualitas tidur buruk dan mayoritas dari mereka adalah perempuan.Â Penyebab utama untuk kualitas tidur yang buruk adalah karena kurangnya jam tidur dan seringnya pergi ke kamar mandi di antara waktu tidur mereka.Â Faktor-faktor kontributor lainnya juga diambil dari kuesioner seperti riwayat keluarga, stres, kecemasan dan kegelisahan, status kesehatan dan penggunaan obat-obatan untuk tidur.Â  Penyebab umum sebagian besar kualitas tidur yang buruk adalah durasi tidur, latensi tidur dan efisiensi tidur. Dengan demikian, dapat disimpulkan bahwa mayoritas geriatri memiliki kualitas tidur yang buruk, dan faktor-faktor yang berkontribusi hanya meningkatkan risiko kualitas tidur yang buruk pada geriatri saat ini.Â Hasil penelitian ini dapat diterapkan sebagai studi analisis untuk penelitian lebih lanjut dalam kualitas tidur dan pola tidur pada geriatri.
Ekstrak daun meniran (Phyllanthus niruri. L) memperbaiki kerusakan sel-Î² pankreas dan menurunkan kadar gula darah tikus wistar hiperglikemia diinduksi aloksan
Authors: Wahjuni Sri
Published: December 2022

Increased production of reactive oxygen species (ROS) is probably one of cause the present of hyperglycemia. This study aims to investigate the effectiveness of Phyllanthusniruri L leaves extract to repair pancreatic b-cells and decrease of blood glucose levels on hyperglycemia wistar rat aloxan induced.This is a true experimental employing pre and posttest control group design. Experimental was started by generating hyperglycemia of the 32 rats using aloxan. Then, the rats were divided into two groups, i.e. control group (C) and treatment group (T). Treatment group was fed with 5,0 mg/Kg bw/d phyllanthus niruri L extract. Â Repaired of pancreatic b-cells for these two groups were compared descriptively using immunohysto-chemistry. In addition blood glucose levels between these two groups were compared statistically using t-test.The results indicate that there was a different between pancreatic b-cells in these two groups. In addition there were also a significant different between blood glucose levels in these two groups, i.e. for control group were 217.46Â±23.38 mg/dL (pretest) and 206.17Â±22.16 mg/dL (posttest) compared to 217.49Â±23.33 mg/dL (pretest) and Â 117.93Â±21.23 mg/dL (posttest) for treatment group. It can be concluded that Phyllanthusniruri L leaves extract in a dose of 5.0 mg/kg bw/d effective to repair pancreatic b-cells disability and also for decreasing blood glucose levels on hyperglycemic wistar rats. This is probably due to the antioxidant and anti inflammation activity of this leaf.Â
Gambaran perilaku masyarakat dalam pemberantasan sarang nyamuk demam berdarah dengue (PSN DBD) dan kemampuan mengamati jentik di wilayah kerja Puskesmas Banjarangkan II
Authors: Chelvam Rubagan , Pinatih I Gede Ngurah Indraguna
Published: December 2022

Dengue Hemorrhagic Fever (DHF) is a disease caused by dengue virus infection which transmitted through Aedes aegypti mosquito bite and still a public health problem in tropical or subtropical areas worldwide.Â  One of the efforts which are considered appropriate in the prevention and eradication of DHF through cut the chain of transmission and controlling the vectors by eradication of mosquito nest caused Dengue Hemorrhagic Fever (PSN DBD). This study used cross sectional design in Puskesmas Banjarangkan II to describe the peopleâ€™s behavior in eradicating mosquito nest caused DHF. Minimum sample size is 35 people which cover 6 villages and 26 hamlets (banjar)/environments in it. The results showed respondents who have poor PSN DBD behavior aound 57.1% and good around 42.9%. Based on the ability to monitor larvaes, respondents who have poor capabilities to observing it around 62.9% whereas who having good capabilitiesapproximately 31.1%. Accordingly, it can be concluded most of the people who included within the scope of Puskesmas banjarangkan II have poor PSN DBD capabilities as well as observing larvae so that it is necessary to do some attempts to overcome it.Â
Skor kualitas hidup dermatologi berkorelasi positif dengan Melasma Area And Severity Index
Authors: Praharsini IGAA , Suryawati Nyoman , Dewi Hasri
Published: December 2022

Melasma adalah gangguan hiperpigmentasi yang terjadi pada kulit di daerah paparan sinar matahari. Kondisi ini seringkali memberikan dampak yang besar akibat lesi wajah yang sangat jelas dan dapat mempengaruhiÂ  kualitas hidup pasienÂ  seperti: menurunnya fungsi sosial, produktivitas serta hilangnya rasa percaya diri. Penelitian cross sectional bertujuan membuktikan adanya pengaruh melasma terhadap kualitas hidup dengan menggunakan nilaiÂ  Melasma Area and Severity Index (MASI)Â Â  yang dihubungkan dengan skor kualitas hidup dermatologi. Empat puluh enam orang sampelÂ  pasien melasmaÂ Â  yang memenuhi kriteria eksklusi dan inklusi diikutsertakan dalam penelitian, yang diperoleh dari pasien rawat jalanÂ  poli kulit dan kelamin RSUP SanglahÂ  periodeÂ  Agustusâ€“Desember 2016. Sampel diambil secaraÂ  Â consecutive sampling. Selanjutnya dilakukan penilaian derajat keparahan melasma dengan skor MASI dan pengisian kuisioner kualitas hidup dermatologi . Data terkumpulÂ  dianalisis dengan SPSS 20 dengan uji korelasiÂ  Spearman-rho. Subyek penelitian terdiri dari 42 perempuan dan 4 laki-laki, dengan rata-rata umur 43.9Â± 6.2. Melasma yang berdistribusi sentrofasial dan tipe melasma campuran mendominasi karakteristik subyek penelitian. Pada penelitian ini didapatkan adanya korelasi positifÂ  kuat antara skor kualitas hidup dermatologi dengan nilai MASI (r = 0.856; p < 0.05). Melasma memberi efek yang besar pada kualitas hidup pasien melasma.
Level of knowledge and attitude towards alzheimer`s disease among people in Sanglah General Hospital, Denpasar, Bali
Authors: Thomas Florence Diana , Nuartha A.A. Bagus Ngurah , Widyadharma I Putu Eka
Published: December 2022

Background: Alzheimer`s disease (AD) is a kind of dementia that causes impair of memory, intuition, and social life in elderly particularly. This study aims to know the public awareness, attitude, and knowledge of AD in Denpasar, BaliMethods: A cross-sectional study was conducted among 70 participants at Sanglah General Hospital by using self-administered questionnaire during April-May 2018 period. Subjects selection using simple random sampling method. Statistical analysis was carried out by using SPSS ver. 17 to know the percentage or proportion regarding with attitude and knowledge of AD.Results: About 39% of participants have a good knowledge, followed by 20% poor knowledge, and 41% donâ€™t know about AD. The study found that 50% of participants have a good attitude, 25% poor attitude, and donâ€™t have attitude regarding with AD. Data comparison showed that students scored higher for attitude than knowledge about 11%.Conclusion: Most of the participants at Sanglah General Hospital have a poor knowledge and attitude regarding with HD
Identifikasi Salmonella spp pada feses penjamah makanan di rumah potong ayam RJ dengan metode kultur
Authors: Arya Prayoga Komang Aditya , Dwi Fatmawati Ni Nengah
Published: December 2022

Latar Belakang: Tifoid merupakan penyakit yang sering menyerang anak- anak dan dewasa yang memiliki sanitasi yang buruk khususnya pada penjamah makanan dan persediaan air minum. Tifoid merupakan penyakit sistemik yang disebabkan oleh bakteri memiliki onset perlahan dengan gejala demam, sakit kepala berat, malaise, anoreksia, batuk tidak produktif pada tahap awal bradikardi yang relatif, splenomegaly, dan rasa tidak nyaman pada daerah abdomen. Penyebab tifoid ialah salmonella typh yang merupakan bakteri gram negative.Metode: Tujuan dari penelitian ini adalah untuk mencegah penyeberan infeksi salmonella dikalangan masyarakat, dengan cara metode kultur bakteri di media agar salmonella-shigella, mac conkey, dan agar xylolse lysine deoxycholate. Hasil: Didapatkan hasil dari total 30 sampel feses penjamah makanan yang di uji pada penelitian ini, dari ketiga media agar didapatkan hasil kultur positif pada 6 sampel dan hasil kultur negative 22 sampel, dan sampel hilang sebanyak 2.Simpulan: Dari hasil penelitian ini dapat disimpulkan bahwa ada hubungan yang bermakna antara status gizi dan angka kejadian pneumonia pada pasien anak yang dirawat di SMF Ilmu Kesehatan Anak RSUP Sanglah.
SYOK SEPTIK DISERTAI HIPOKSIA HEPATIK PADA RUMAH SAKIT UMUM DAERAH KLUNGKUNG, BALI-INDONESIA: SEBUAH LAPORAN KASUS
Authors: Sudiantara Putu Herdita , Dharmapala Juslaksmi
Published: December 2022

Latar Belakang: Sepsis merupakan suatu kondisi sindroma klinik yang terjadi oleh karena respon tubuh yang berlebihan terhadap suatu infeksi yang meliputi proses inflamasi, autoimun, dan koagulasi. Penanganan sepsis membutuhkan diagnosis yang cepat serta terapi yang tepat untuk menurunkan angka mortalitas yang diakibatkan oleh kondisi ini. Laporan kasus ini bertujuan untuk memberikan gambaran sepsis yang disertai dengan hipoksia hepatik serta penanganan yang diberikan untuk menangani kondisi tersebut.Kasus: Pasien laki-laki 68 tahun datang diantar keluarga ke Rumah Sakit Umum Daerah Klungkung dengan keluhan penurunan kesadaran. pemeriksaan fisik ditemukan adanya sesak (laju respirasi 30 kali/menit), tekanan darah 60 mmHg per palpasi, saturasi 85% via non rebreathing mask oksigen 12 liter per menit, denyut nadi 122 kali per menit, GCS E1V3M4, suhu 35,9o C. Kedua sklera tampak mengalami ikterus, dari pemeriksaan fisik paru ditemukan adanya ronkhi bilateral, akral teraba dingin. Melalui pemeriksaan complete blood count ditemukan adanya leukositosis (26,3 x 109/L) dengan predominan limfosit (11,2 x 109/L). Dari pemeriksaan fungsi hati ditemukan adanya peningkatan SGOT (473 mg/dl) dan SGPT (208 mg/dl), total protein yag rendah (4,6 mg/dl), dan albumin yang rendah (2,5 mg/dl). Pemeriksaan fungsi ginjal ditemukan adanya peningkatan dari ureum (137 mg/dl) dan kreatinin (2,1 mg/dl).Simpulan: Penanganan sepsis harus didasarkan pada diagnosis cepat dan penanganan resusitasi yang tepat untuk mengurangi angka mortalitas yang disebabkan oleh sepsis.
Prevalensi infeksi soil transmitted helmith di Sekolah Dasar Negeri 1 Padangbulia Kecamatan Sukasada Kabupaten Buleleng, Bali-Indonesia
Authors: Devi Ni Putu Akopita , Sudarmaja I Made , Swastika Kadek
Published: December 2022

Latar Belakang: Pada perkembangan global yang sudah modern ternyata masih banyak kejadian infeksi cacing pada anak-anak. Infeksi cacing ini juga berhubungan dengan status gizi anak-anak. Beberapa penelitian juga menyebutkan bahwa kebersihan diri pada anak-anak sangat berpengaruh dengan terjadi nya infeksi cacing seperti perilaku mencuci tangan, memotong kuku, kebersihan yang dikonsumsi, dan masih banyak lagi. Penelitian ini bertujuan untuk mengetahui prevalensi infeksi cacing, dan juga hubungan status gizi serta kebersihan diri pada anak sekolah dasar di SD Negeri 1 Padangbulia Kecamatan Sukasada Kabupaten Buleleng.Metode: Penelitian ini adalah penelitian deskriptif dengan studi total sampling dengan jumlah sampel 127 orang. Instrumen yang digunakan adalah kuesioner tentang kebersihan diri untuk mendapatkan katagori baik dan buruk, serta perhitungan berat badan dan tinggi badan menggunakan timbangan dan microtoise.Hasil: Dari 127 siswa, 20 siswa dikatagorikan kurus, 84 siswa dikatagorikan normal dan 11 orang dikatagorikan gemuk. Hampir sebagian besar kebersihan siswa sangat baik dengan rajin mencuci tangan, memotong kuku, makan makananan yang bersih, dan bermain dengan menggunakan alas kaki. Selain itu ditemukan 6 kasus dengan infeksi askariasis dan trikuriasis.Simpulan: Pada penelitian ini kebersihan pada siswa sekolah dasar sudah baik begitu pula status gizinya. Kedepannya diharapkan adanya penelitian lebih lanjut dengan design penelitian yang lebih baik tentang infeksi cacing, status gizi, dan kebersihan diri. Prevalensi cacingan pada penelitian ini adalah 0,04%.
Distant Views of the Holy Land
Authors: Cobbing Felicity , Jacobson David
Published: December 2022

The Holy Land has been an enduring magnet for visitors seeking to retrace the footsteps of biblical prophets, kings and saints and to glimpse the setting of events recorded in the Scriptures. This book offers a selection of over 350 early photographs, paintings, and drawings of the length and breadth of the Holy Land from the rich repository of images in the archives of the Palestine Exploration Fund. As these images were produced before modern development impacted on these landscapes they are an invaluable resource. The pictures are accompanied by 7 maps and plans showing the locations depicted and a commentary describing the biblical context, informed by up-to-date scholarship. The book is divided into five chapters; an introduction which includes a brief account of pilgrimage to the Holy Land through the ages, followed by a series of geographical ‘tours’ through Galilee, Samaria, and Judea and Philistia, before culminating with a focus on the two main sites of interest for the traveller: Bethlehem and Jerusalem. While often very beautiful in their own right, the pictures also reflect the interest and sensibilities of the photographers and those who collected them, and capture the opposing undercurrents of scientific enquiry and piety characteristic of 19th Century European society. In the case of the photographers engaged by the PEF, a striving for objectivity is strikingly evident in their work.
Yukker: Focus on an Innovative Social Start-Up
Authors: Accordino Patrizia , Coppolino Raffaella , Giannetto Carlo , La Rocca Elvira Tiziana
Published: December 2022

Background: Innovation is a central topic in social entrepreneurial inquiries and is recognised as playing an important role in successful social experiences. However, the relationship between networks and social venture formation is still an open question.

Research objectives: The study aims to analyse the business model of innovative digital start-ups with social goals and to identify and understand the elements influencing their birth, growth, and business performance.

Research design and methods: The paper uses a single case study research design focused on the innovative social start-up “Muoviti in libertà” and its app – Yukker.

Results: Analysing the Yukker business model has allowed to identify and understand crucial elements influencing innovative social start-ups' birth, growth, and business performance.

Conclusions: It is essential to design a network to increase relationships for entrepreneurship and for performing better in strategic and leading change.
Exploration of Social Entrepreneurship Ecosystems in Thailand and Myanmar
Authors: Meallem Michael Jack , Herpich Stifani
Published: December 2022

Background: Although the social enterprise ecosystems in Thailand and Myanmar are at different levels of development, they share common challenges that need to be addressed to ensure that the sector lives up to its potential of helping these countries fully achieve their Sustainable Development Goals.

Research objectives: The aim of this research is to identify common issues that social entrepreneurs in Thailand and Myanmar are facing within the ecosystems they operate in, and thus recommend specific actions that institutions of higher education in Thailand and Myanmar can take to support these ecosystems develop.

Research design and methods: This research utilised desk-based secondary research from existing country reports, and primary research in the form of online surveys and focus groups with different stakeholders such as social entrepreneurs, local government officials and educators.

Results: We identified several common challenges that social enterprises in these two countries face which include the centralisation of key ecosystem actors, lack of funding access, poor impact measurement and misconceptions of the sector as a whole among stakeholders.

Conclusions: As a result of the research findings, we have provided several policy recommendations to higher education institutions wishing to engage and support their local social enterprise ecosystems.
Sokolsky Grigory Ivanovich: contribution to the development of domestic and world medicine. To the 215th anniversary of the birth
Authors: Abdulganieva D. I. , Nurullina G. I. , Khalfina T. N. , Ismagilova D. A. , Trusov N. A.
Published: December 2022

The article is dedicated to the 215th anniversary of the birth of Grigory Ivanovich Sokolsky, a well-known Russian clinician and scientist who made a huge contribution to the development of clinical diagnostics of diseases, phthisiology, internal diseases, especially rheumatology. The work that laid the foundation for the scientific activity of G.I. Sokolsky, "On the rheumatism of the cardiac muscle tissue" (1836), brought him national and world fame, and formed the theory that rheumatism is a systemic disease with a primary lesion of the heart and joints. G.I. Sokolsky sought to teach students at the bedside. He was the first who began to demonstrate patients in lectures and actively introduce auscultation and percussion into clinical practice, as well as into teaching, paying special attention to their exceptional diagnostic significance and the need for joint use. An outstanding mind, broad erudition, passion, deep faith in his ideas caused an ambiguous attitude of contemporaries, which left its mark on life. The article presents previously unpublished facts about the life of G.I. Sokolsky, his activities and personality traits, unique archival documents, photographs and manuscripts.
In vitro callogenesis essays to induce somatic embryogenesis of the Tunisian chickpea
Authors: KAHLAOUI Samiha , BOUAMAMA-GZARA Badra , BOKRI Hana , HARZALLAH-SKHIRI Fethia , STAMBOULI-ESSASSI Sondes
Published: December 2022

The present study was the first report on the somatic embryogenesis of the Tunisian chickpea (Cicer arietinum L.) particularly supposed to be recalcitrant and difficult to manipulate in vitro. An efficient protocol has been developed for inducing indirect somatic embryogenesis derived from immature zygotic embryo axis, young leaflet and hypocotylar explants. Callogenesis was achieved on full-strength Murashige and Skoog's (1962) (MS) basal medium supplemented with two auxin/cytokinin combinations; 2,4-dichlorophenoxyacetic acid (2,4-D) and 6-furfurylamonopurine (KIN) or 1-naphthaleneacetic acid (NAA) and 6-benzylaminopurine (BAP) to establish the phytohormones requirement to promote the best induction of friable calli. For somatic embryos induction, embryogenic calli developed from zygotic embryo axes, leaflet and hypocotylar explants were cultured on MS full strength and MS/2, half strength, free of phytohormones media. This study found that all explants exhibited high frequency of callus induction. For immature zygotic embryo axes and young leaflet explants, media containing the combination of 2,4-D and KIN were best effective for inducing callogenesis and friable calli. The most important embryogenic callus percentages were obtained on the culture medium containing the highest concentrations of 2,4-D (2 mg L-1) and KIN (0.5 mg L-1). However, media containing the combination NAA and BAP were best effective for inducing embryogenic calli on hypocotylar explants. A maximal rate of embryogenic calli was reached on medium containing 3 mg L-1 NAA and 1 mg L-1 BAP. The highest number of somatic embryos was obtained with embryogenic calli derived from embryo axis explants and cultured on MS half strength free phytohormones medium. About 56% of somatic embryos converted successfully into fertile plantlets.
Cytotoxic activity of Thymus capitatus collected from Hail region in Saudi Arabia with mechanistic study via induction of caspase-dependent apoptosis and S-phase arrest
Authors: YOUNES Kareem M. , HUWAIMEL Badr , ABOUZIED Amr S. , ALRASHIDI Khloud O. , ALAWAD Amani F. , ALMESMAR Nourah O. , ALRASHIDI Zainab M.
Published: December 2022

Thymus capitatus is a plant grows in Mediterranean area and some Arab countries such as Saudi Arabia. It possesses numerous medicinal values. Its common name is Zaatar and it belongs to family Lamiaceae Thymus capitatus leaves and stem were collected from Hail region, Saudi Arabia. Then both leaves and stem were extracted with ethanol. This study was performed to evaluate cytotoxic activity of Thymus capitatus leaves and stem ethanolic extract in details. Doxorubicin was used as a standard and the relevant half maximal inhibitory concentration (IC50) values were computed for each cell line by 3-(4,5- diemthylthiazole-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. In addition, further mechanistic study was carried out by using Apoptosis assay to explore cytotoxic activity of plant extract. Both leaves and stems extracts were screened against HepG2, A-549, HCT-116 and   MCF-7 cancer cell lines. It was found that leaves’ extract shows high and moderate cytotoxic activity against both A-549 and HepG2 cancer cell lines, respectively (with IC50 = 13.6 and 21.5 μg/ml, respectively), while stem’s extract exerted moderate cytotoxic activity against A-549 cancer cell lines (with IC50 = 21.38 μg/ml).  Further mechanistic study was carried out on A-549 cells by using apoptosis assay. It showed that leaves’ extract resulted in arrest of S-phase and caused apoptosis through activation of caspase-3, p53 and Bax, in addition to down regulation of Bcl-2.
Cloning and function analysis of DlWRKY9 gene in longan (Dimocarpus longan)
Authors: Dengwei JUE  , XIA Yuxin , GUO Qigao , LIU Huan , SANG Xuelian
Published: December 2022

WRKY is one of the largest plant transcription factors (TFs) which is widely involved in plant growth, development, and responses to stresses. In the present study, a WRKY TF DlWRKY9 was cloned from longan (Dimocarpus longan). The coding sequence (CDS) of DlWRKY9 is 762 bp in length and encodes 253 amino acids. It has a typical WRKY domain and zinc finger structure which belongs to type IIa WRKY protein. The molecular weight of DlWRKY9 protein was 30.27kda and the theoretical isoelectric point (PI) was 5.24. It is an unstable hydrophilic protein. The secondary structure of DlWRKY9 protein consists of helical structure (17.39%), extended chain (8.70%) and other structures (turn and random coil) (73.91%). The amino acid sequence of DlWRKY9 protein had the highest similarity with DlWRKY9 (xp_006450293.1) of citrus Clementina. DlWRKY9 gene promoter elements contain light, abscisic acid, gibberellin, jasmonic acid and other response elements. The results of qRT-PCR showed that the relative expression level of DlWRKY9 gene in pericarp was higher, followed by young fruits and floral organs. Meanwhile, DlWRKY9 gene specifically down-regulated in the early stage of flower induction in ‘Sijimi’ (SJ) longan. The results of transient expression of Arabidopsis protoplasts showed that the fluorescence signal was mainly concentrated in the nucleus. Moreover, overexpression of DlWRKY9 in Arabidopsis promoted early flowering. These results provide useful information for revealing the biological roles of DlWRKY9 in longan and increase our understanding of the WRKY family in fruit trees.
Promotion of tomato growth by Trichoderma sp. under shade mesh conditions
Authors: URÍAS-GARCÍA Crescencio , PEREZ ALVAREZ Sandra , HÉCTOR-ARDISANA Eduardo F. , FLORES CÓRDOVA María A.
Published: December 2022

Chemical fertilizers are frequently used in agriculture with harmful effects on ecological components, so the use of microorganisms as growth regulators is an agricultural practice increasingly used today. The aim of this research was to evaluate Trichoderma sp. as growth regulator in tomato plants. Trichoderma sp. isolated from soils was grown on solid PDA medium for morphological characterization of the fungus. An experiment to analyse the interaction between Trichoderma sp. and shade mesh conditions was established, where: T1 = Trichoderma sp.; T2 = without Trichoderma sp. (fertilization recommended for the crop was applied); T3 = shade mesh and T4 = without shade mesh. Several variables were evaluated in the plants and in the fruits. The macroscopic characteristics showed mycelium with a cottony morphology and a dark green coloration, and the microscopic characteristics of the fungus were conidiophores with a branch, phialides and ovoid to ellipsoid conidia. Interaction of Trichoderma sp. and shade mesh had a significant effect on plant height, number of flowers and number of fruits, with the greater values with Trichoderma sp. and shade mesh. Regarding the evaluation of the fruits significant differences were found in the weight, diameter, length, and colour (L and a* value) but not in b* value.
Estratégias para a Escuta Especializada de vítimas de violência sexual em redes intersetoriais*
Authors: Dourado Ana Lucia , Bidarra Zelimar Soares
Published: December 2022

Resumo: Este artigo se embasa em dados obtidos com pesquisas (documental e de campo), realizadas entre 2018 e 2021, para demonstrar os percursos e os desafios para a definição de estratégias, visando orientar a realização de entrevista de Escuta Especializada para o atendimento de crianças e adolescentes vítimas de violência sexual no âmbito das experiências de duas redes intersetoriais de políticas públicas, organizadas nos municípios de Cascavel (REDE) e Toledo (RIPS), situados na região oeste do Paraná.
RISK OF PRENEOPLASTIC LESIONS IN MUCOSAL PROJECTIONS OF DIFFERENT SIZES OF THE COLUMNAR EPITHELIUM IN THE LOWER ESOPHAGUS
Authors: Copetti Hairton , Copetti Leonardo , Copetti Laura , Felin Giulliano Danezi , Felin Giancarllo Danezi , Felin Carollina Danezi , Felin Fellipe Danezi , Chiesa Vitória
Published: December 2022

ABSTRACT BACKGROUND: Barrett's esophagus is an acquired condition that predisposes to the development of esophageal adenocarcinoma. AIMS: The aim of this study was to establish an association between the endoscopic and the histopathological findings regarding differently sized endoscopic columnar epithelial mucosa projections in the low esophagus, under 3.0 cm in the longitudinal extent. METHODS: This is a prospective study, including 1262 patients who were submitted to upper gastrointestinal endoscopy in the period from July 2015 to June 2017. The suspicious projections were measured and subdivided into three groups according to the sizes encountered (Group I: <0.99 cm; Group II: 1.0–1.99 cm; and Group III: 2.0–2.99 cm), and biopsies were then performed. RESULTS: There was a general prevalence of suspicious lesions of 6.42% and of confirmed Barrett's lesions of 1.17%, without a general significant statistical difference among groups. However, from Groups I and II to Group III, the differences were significant, showing that the greater the lesion, the higher the probability of Barrett's esophagus diagnosis. The absolute number of Barrett's lesions was 7, 9, and 6 for Groups I, II, and III, respectively. CONCLUSIONS: The findings led to the conclusion that even projections under 3.0 cm present a similar possibility of evolution to Barrett's esophagus. If, on the one hand, short segments are more prevalent, on the other hand, the long segments have the higher probability of Barrett's esophagus diagnosis, which is why biopsies are required in all suspicious segments.
Percepção da população sobre a atuação das autoridades e das comunidades no controle das arboviroses
Authors: Costa Luana Dias da , Barros Alana Dantas , Lorenzo Cláudio , Mendonça Ana Valéria Machado , Sousa Maria Fátima de
Published: December 2022

RESUMO O controle ambiental para a prevenção das arboviroses depende tanto de ações dos poderes públicos quanto do envolvimento das comunidades. A presente pesquisa analisou a percepção de 385 pessoas em 17 municípios das 5 regiões do País sobre a atuação das autoridades e da própria comunidade em relação ao controle e à prevenção da dengue. Independentemente da região, os participantes reconheceram que ações como saneamento básico, coleta regular de lixo, fiscalização de terrenos baldios e domicílios fechados têm sido frequentemente negligenciadas pelas autoridades. A responsabilização da comunidade, na figura do vizinho que não cumpre as medidas de controle, também foi percepção dominante, chamando a atenção a ausência de qualquer reconhecimento sobre como condições sociais desfavoráveis influenciam nas dificuldades para a realização dos procedimentos preventivos. Reflete-se ainda acerca dos prejuízos que a pandemia de Covid-19 tem causado às práticas preventivas e seus possíveis impactos futuros.
INHUMANIDAD, ORGANIZACIÓN Y SUBJETIVACIÓN EN LA OBRA DE FERNANDO CRUZ KRONFLY
Authors: Rojas William Rojas , Rojas Diego Hernán Varón , Villano Ximena Giraldo
Published: December 2022

RESUMEN Este artículo busca delinear los hallazgos que dan cuenta del pensamiento de Fernando Cruz Kronfly y su crítica a la teoría organizacional y administrativa contemporánea. El objetivo del estudio se centra en analizar los conceptos de Inhumanidad, Organizaciones y Subjetividad en el contexto del pensamiento administrativo, sobre los cuales ha volcado su crítica reflexiva nuestro autor. Para dar cumplimiento a este propósito, se analizó una entrevista en profundidad que conduce a la lectura de su obra, y la construcción de reseñas analíticas realizadas a más de quince documentos orientados al eje temático propuesto. El pensamiento de Fernando Cruz Kronfly crítica la realidad organizacional y administrativa que afianza y robustece los discursos del rendimiento maximalista de un capitalismo que viola la humanidad en el trabajo. Con el estudio se logra mostrar las diferentes problematizaciones y algunos de los principales aportes a la teoría organizacional latinoamericana, en especial, aquella que ha sido capaz de ver las fragilidades de las conceptualizaciones que soportan los humanismos administrativos de fachada.
Influência do apoio social e capital social no consumo alimentar de adultos no sul do Brasil
Authors: Bierhals Vitor Rodrigues , Bairros Fernanda Souza de , Olinto Maria Teresa Anselmo , Silva Janaína Cristina da , Garcez Anderson , Pattussi Marcos Pascoal
Published: December 2022

Resumo Introdução As escolhas alimentares podem ser influenciadas por apoio social e capital social. Objetivo Investigar as relações do apoio social e capital social com o consumo alimentar. Método Trata-se de um estudo transversal, de base populacional, com uma amostra aleatória de 1.098 adultos (≥ 18 anos de idade) de uma cidade no Sul do Brasil. O apoio social foi mensurado por meio da escala Medical Outcomes Study (MOS), e o capital social contemplou a avaliação dos indicadores de coesão social, apoio dos vizinhos, controle social informal, eficácia política e ação social. Para o consumo alimentar, utilizou-se de uma escala com base nas orientações do guia alimentar para a população brasileira. Resultados A média de idade da amostra foi de 44 anos (DP[Desvio-padrão] = 15,8), e identificou-se um consumo alimentar adequado em 38,6% (IC95%: 35,7 a 41,5). Após ajuste, observou-se uma probabilidade 40% maior para adoção de consumo alimentar adequado (saudável) entre os indivíduos com maior nível de apoio social (OR = 1,47; IC95%: 1,07 a 2,03), coesão social (OR = 1,40; IC95%: 1,02 a 1,92) e apoio dos vizinhos (OR = 1,45; IC95%: 1,04 a 2,02). Conclusão Os aspectos psicossociais, tanto individual quanto contextual, podem desempenhar um papel importante no consumo alimentar saudável em adultos.
Avaliação da saúde bucal em uma coorte de idosos não institucionalizados
Authors: Freitas Yan Nogueira Leite de , Pinheiro Natália Cristina Garcia , Lima Kenio Costa
Published: December 2022

Resumo Introdução Sabe-se que os instrumentos epidemiológicos comumente utilizados para aferir as condições bucais, como o CPO-d e CPI, não são sensíveis o suficiente para discriminar idosos em relação à saúde bucal. Objetivo Identificar as alterações na progressão da condição de saúde bucal de idosos não institucionalizados, a partir da aplicação de um indicador multidimensional. Método Trata-se de um estudo longitudinal, realizado em uma coorte de 183 idosos do município de Macaíba/RN. Uma análise fatorial possibilitou que todas as variáveis coletadas, tanto as de saúde bucal quanto as socioeconômicas, demográficas e do estado geral de saúde, fossem consideradas para a produção do indicador multidimensional de saúde bucal. Ademais, foram utilizados o teste t de Student para amostras dependentes, o teste do Qui-Quadrado e o Risco Relativo (IC 95%), na busca de associações entre a saúde bucal dos idosos e as variáveis independentes. Resultados Observou-se que 22,2% dos idosos pioraram sua condição de saúde bucal ao longo do tempo, e que ser casado foi fator de proteção para evitar essa deterioração. Os fatores mais relacionados à mudança da condição de saúde bucal foram “cárie radicular e necessidade de extração”, e “idosos jovens com maior densidade domiciliar”. Conclusão O indicador proposto reforça a importância de buscar instrumentos que vão além das dimensões dentárias para discriminar a saúde bucal, facilitando o planejamento de ações em prol da saúde bucal dos idosos.
Parto y subjetivación femenina. Un proyecto artístico con madres al sur de Chile
Authors: García-Huidobro Munita María Rosario , Schenffeldt Ulloa Ninoska Yanela
Published: December 2022

Resumen: El artículo surge de la investigación artística “Retrarelatos de un parto olvidado” realizada con 48 madres chilenas que iban relatando sus vivencias del parto y resignificándolas de manera relacional y mediada. Este espacio de mediación artística configuró un espacio libre y de reconocimiento, donde pudieron problematizar sus vivencias. Se destaca la categoría de empoderamiento, donde se puede observar el impulso de cuestionar lo vivido desde sus propias necesidades, desnaturalizando la violencia e irrumpiendo las barreras que no les permiten tomar decisiones de sus propios partos. Al problematizar la experiencia desde la creación artística como mediación, se transforman las subjetividades y se superpone al parto en una esfera política para su agenciamiento. La reconfiguración de subjetividades femeninas da lugar a la discusión pública del parto como un espacio necesitado de responsabilidad social desde las artes.