bluuebunny/crossref_metadata_2025 huggingface dataset:
ASSESSING THE UNIVERSITY STUDENTS’ ENTREPRENEURIAL INTENTION: ENTREPRENEURIAL EDUCATION AND CREATIVITY
Authors: Saptono Ari , Purwana Dedi , Wibowo Agus , Wibowo Setyo Ferry , Mukhtar Saparuddin , Yanto Heri , Hadi Utomo Sugeng , Kusumajanto Djoko Dwi
Published: August 2019

Purpose of the study: This study examines the impact of creativity and entrepreneurship education on student entrepreneurial intentions at Jakarta State University. Methodology: This study, we applied quantitative research which conducting in two-phase First, we perform exploratory factor analysis test, and the second phase, we confirmatory factor analysis using AMOS version 18. Main Findings: This study carried out the findings that there is an impact on creativity on entrepreneurial education, lectures on individual creativity, entrepreneurial education on entrepreneurial intention, and creativity supported in the university on individual creativity. Furthermore, creativity supported not impact on entrepreneurial intention, and individual creativity has not to impact on entrepreneurial intention. Applications of this study: This research can be used by university leaders to increase students’ intention to become entrepreneurs through optimizing entrepreneurship education and creativity support from universities. Novelty/Originality of this study: In this study, we found that there was an influence of lecturer on creativity on entrepreneurship education. Previous researchers have never revealed this finding. Our research also found the impact of individual creativity on the intention of entrepreneurship. This finding has not been revealed in some previous studies.
THE MODERATING ROLE OF JOB EMBEDDEDNESS ON THE EFFECT OF ORGANISATIONAL JUSTICE AND ORGANISATIONAL LEARNING CULTURE ON TURNOVER INTENTION: A CONCEPTUAL REVIEW
Authors: Saoula Oussama , Fareed Muhammad , Hamid Rawiyah Abd , Esmail Abu Al-Rejal Hussein Mohammed , Ismail Saiful Azizi
Published: August 2019

Purpose: Employee’s turnover has been investigated by many researchers as an organisations’ negative outcome. The organizations that facing high rates of turnover should examine the fundamental reasons that cause employees’ turnover in order to reach real solutions to this problem. For that, they should ask a dynamic question, why some employees stay and some leave?

Methodology: The reasons may seem difficult and consistent to the preferences and necessities of the employees. From another aspect, the majority of research in the context of turnover intention have been conducted in the western contexts, therefore it is worthwhile to encourage more studies in non-western settings to discover new understandings related to the problem.

Results: Malaysia is considered as one of the developing countries that is having high turnover of employees in many sectors. Consequently, this study proposed a research framework to examine the relationship between organisational justice (OJ)’s three dimensions (Distributive justice, procedural justice and interactional justice), organisational learning culture (OLC) and turnover intention (TI). Furthermore this study recommended the moderating role of Job embeddedness (JE) in this relationship. Hence, the suggested research framework will contribute to the body of knowledge through providing new insights.
PROFESSORES INICIANTES NA EDUCAÇÃO PROFISSIONAL E TECNOLÓGICA: O SILÊNCIO NO BANCO DE TESES DA CAPES NOS ANOS DE 2011 E 2012
Authors: Wiebusch Eloisa Maria
Published: August 2019

O presente estudo buscou analisar o estado do conhecimento sobre professores iniciantes na educação profissional e tecnológica, a partir das pesquisas de cursos de mestrado e doutorado no Brasil. Realizou-se um mapeamento das produções científicas sobre a temática com base na pesquisa bibliográfica, com abordagem qualitativa e análise de conteúdo proposta por Bardin (2009) para a leitura, análise e interpretação dos dados. Foram identificados 14 trabalhos, sendo 12 dissertações e duas teses sobre os professores iniciantes na educação básica. É um campo inexpressivo de investigações, existe um silenciamento, foi o que revelou o estado do conhecimento. Neste estudo não foi encontrada nenhuma dissertação ou tese sobre os professores iniciantes na educação profissional e tecnológica, mesmo com a expansão dos Institutos Federais, com novos câmpus.Palavras-chave: Educação profissional e tecnológica. Estado do conhecimento.Professores iniciantes. -US;mso-bidi-language:AR-SA'>Plano Nacional de Educação.
A EDUCAÇÃO SEXUAL NA PERSPECTIVA DAS PROFESSORAS DO 5º ANO DO ENSINO FUNDAMENTAL
Authors: Silva Renata Geremias da , Camargo Gislene
Published: August 2019

O presente artigo visa investigar de que forma as/os professoras/es do 5º ano trabalham a Educação Sexual com seus/suas alunos/as. Para a realização da presente pesquisa adotou-se uma metodologia qualitativa e utilizou-se como instrumento de coleta de dados o questionário, que foi aplicado a 7 (sete) professoras (todas são do gênero feminino) que lecionam na cidade de Criciúma - SC. Após a análise dos dados coletados, pode-se afirmar que há pouca compreensão acerca do conceito de sexualidade e Educação Sexual por grande parte das pesquisadas e que a Educação Sexual é ausente no currículo das escolas. Por isso, ao afirmarem sentirem-se preparadas para trabalhar a Educação Sexual, a maioria das professoras se contradiz, já que não é possível a realização de um trabalho efetivo tendo pouca compreensão sobre Educação Sexual e com sua ausência no currículo escolar.Palavras-chave: Sexualidade. Educação Sexual. Currículo
PSYCHOLOGICAL FACTORS OF EMOTIONAL DISADAPTATION OF ELDERLY PEOPLE
Authors: Guryanova Inna
Published: August 2019

Abstract. People of old age do face a number of difficulties (the ceasing work ac-tivity, the loss of near relatives, the emotional, financial and functional dependence on oth-er people, etc.), which drastically change their habitual life style and lead to emotional dis-adaptation.Key words: aging, types of aging, the elderly, old age people, emotional disadapta-tion, temporal disadaptation, situational disadaptation, refractory disadaptation.Resumo: As pessoas de idade avançada fazer enfrentam uma série de dificuldades (a atividade de trabalho cessação, a perda de parentes próximos, a dependência emocio-nal, financeira e funcional em outras pessoas, etc.), que mudar drasticamente seu estilo de vida habitual e levar a disadaptation emocional.Palavras-chave: Tipos de envelhecimento, os idosos, as pessoas de idade avan-çada, inadaptação emocional,inadaptação temporal, inadaptação situacional, inadaptação em refratários.
ABOUT SOME TRADITIONS AND PEOPLE OF SOUTH URALS IN RUSSIAN FEDERATION
Authors: Guseva Liudmila , Sergeev Eugenii , Tiatiushkina Iana
Published: August 2019

Abstract: This article overviews some cultural and religious traditions of the people of Russian Federation and traces their history and their impact on modern society. The social class of Cossacks that formed the basis of the population of South Urals is briefly described in the historical retrospective.Keywords:tradition, holidays, Cossacks, South Urals.Resumo: Este artigo revê algumas tradições culturais e religiosas do povo da Federação Russa e traça a sua história e seu impacto na sociedade moderna. A classe social dos cossacos que formou a base da população do sul dos Urais é descrito brevemente na retrospectiva histórica.Palavras-chave:tradição, feriados, cossacos, Urais do sul.
Development and experimental studies of heat insulating coatings of basalt and glass-fiber tubing
Authors: Komkov M.A. , Bolotin Yu.Z. , Vasiljeva T.V. , Zarubina O.V.
Published: August 2019

The study shows that in order to significantly reduce the thermal conductivity coefficient of heat insulating materials made of staple basalt raw fibers, it is necessary to grind and clean them from impurities by liquid method. Within the research, we found that tubing heat insulating coating has the insulation wall thickness and mass per unit length limitations. In this paper we give the results of studying high-temperature and low-density heat insulation of short basalt fibers and alumina bundles.
Resistance mechanisms involved in complex immunity of wheat against rust diseases
Authors: Skolotneva E. S. , Salina E. A.
Published: August 2019

The review is devoted to the disclosure of the modern concept of plant immunity as a hierarchical system of plant host protection, controlled by combinations of major and minor resistance genes (loci). The “zigzag” model is described in detail for discussing the molecular bases of plant immunity with key concepts: pathogen-associated molecular patterns triggering innate immunity, ambivalent effectors causing susceptibility, but when interacting with resistance genes, a hypersensitive reaction or alternative defense mechanisms. There are three types of resistance in cereals: (1) basal resistance provided by plasma membrane-localized receptors proteins; (2) racespecific resistance provided by intracellular immune R-receptors; (3) partial resistance conferred by quantitative gene loci. The system ‘wheat (Triticum aestivum) – the fungus causing leaf rust (Puccinia triticina)’ is an interesting model for observing all the resistance mechanisms listed above, since the strategy of this pathogen is aimed at the constitutive use of host resources. The review focuses on known wheat genes responsible for various types of resistance to leaf rust: race-specific genes Lr1, Lr10, Lr19, and Lr21; adult resistance genes which are hypersensitive Lr12, Lr13, Lr22a, Lr22b, Lr35, Lr48, and Lr49; nonhypersensitive genes conferring partial resistance Lr34, Lr46, Lr67, and Lr77. The involvement of some wheat R-genes in pre-haustorial resistance to leaf rust has been discovered recently: Lr1, Lr3a, Lr9, LrB, Lr19, Lr21, Lr38. The presence of these genes in the genotype ensures the interruption of early pathogenesis through the following mechanisms: disorientation and branching of the germ tube; formation of aberrant fungal penetration structures (appressorium, substomatal vesicle); accumulation of callose in mesophyll cell walls. Breeding for immunity is accelerated by implementation of data on various mechanisms of wheat resistance to rust diseases, which are summarized in this review.
Sources of the mitochondrial gene pool of Russians by the results of analysis of modern and paleogenomic data
Authors: Malyarchuk B. A.
Published: August 2019

Paleogenomic studies of recent years have shown that the Bronze Age migrations of populations of the PontoCaspian steppes from the east to the west of Europe had a great influence on the formation of the genetic makeup of modern Europeans. The results of studies of the variability of mitochondrial genomes in the modern Russian populations of Eastern Europe also made it possible to identify an increase in the effective population size during the Bronze Age, which, apparently, could be related to the migration processes of this time. This paper presents the results of analysis of data on the variability of entire mitochondrial genomes in the modern Russian populations in comparison with the distribution of mtDNA haplogroups in the ancient populations of Europe and the Caucasus of the Neolithic and Bronze Age. It was shown that the formation of the modern appearance of the Russian mitochondrial gene pool began approximately 4 thousand years B.C. due to the influx of mtDNA haplotypes characteristic of the population of Central and Western Europe to the east of Europe. It is assumed that the migrations of the ancient populations of the Ponto-Caspian steppes in the western direction led to the formation of mixed populations in Central Europe, bearing mitochondrial haplogroups H, J, T, K, W characteristic of Western and Central Europeans. Further expansion of these populations to the east of Europe and further to Asia explains the emergence of new features of the mitochondrial gene pool in Eastern Europeans. The results of a phylogeographic analysis are also presented, showing that the features of the geographical distribution of the subgroups of the mitochondrial haplogroup R1a in Europe are a reflection of the “Caucasian” component that appeared in the gene pools of various groups of Europeans during the migration of the Bronze Age. The results of phylogeographic analysis of mitochondrial haplogroups U2e2a1d, U4d2, N1a1a1a1, H2b, and H8b1 testify to the migrations of ancient Eastern Europeans to Asia – the south of Siberia and the Indian subcontinent.
Epigenetics of suicidal behavior
Authors: Mustafin R. N. , Kazantseva A. V. , Enikeeva R. F. , Davydova Yu. D. , Malykh S. B. , Viktorov V. V. , Khusnutdinova E. K.
Published: August 2019

Suicide is the second leading cause of death among young people and therefore being a serious global problem worldwide. The study of genetic and epigenetic factors in the development of suicidal behavior plays an important role in the development of advanced methods of diagnosis and treatment of this pathology. The role of hereditary factors in the development of suicidal behavior is estimated at 30–55 %, with a pronounced comorbidity with other psychopathologies. The study of genetic liability to suicidal behavior is based on molecular-genetic methods including association and linkage analyses, chip gene expression arrays, and genome-wide association studies. Published data identified multiple genes including those involved in the functioning of serotonergic (SLC6A4, TPH, 5-HT1A), hypothalamic-pituitary-adrenal systems (FKBP5) and polyamines (SAT and OATL1) associated with suicidal behavior. However, the diversity of interacting genetic loci complicates the interpretation of the development of a complex phenotype of pathology and prevents the association from being detected. To solve this problem and interpret the missing relationship between the environment and the genome, promising results were obtained from a study of epigenetic factors, which affected the expression of a number of candidate genes involved in brain functioning in suicidal behavior. The analysis of a brain obtained from suicide victims, representing a unique tool for the analysis of modified genomic processes, revealed a wide range of reprogramming patterns of DNA methylation in promoters of the genes of polyamine (OAZ1, OAZ2, AMD1, ARG2, SKA2), serotonergic (SLC6A4) and GABAergic (GABRA1) systems, HPA-axis (GR, NR3C1), tyrosine kinase (TrkB) receptors, brain-derived neurotrophic factor (BDNF). The role of histone modifications in distinct genes (Cx30, Cx43, TrkB.T1) and the expression of specific long noncoding RNAs and microRNAs in the development of suicidal behavior, which is promising for the development of diagnostic algorithms and target therapy, is discussed.
A thorny pathway of macrophage activating factor (GcMAF): from bench to bedside
Authors: Ostanin A. A. , Kirikovich S. S. , Dolgova E. V. , Proskurina А. S. , Chernykh E. R. , Bogachev S. S.
Published: August 2019

Vitamin D3 Binding Protein (DBP) is a multifunctional glycoprotein whose main role is to transport vitamin D3 and its metabolites, but it also is the precursor of the macrophage activating factor (GcMAF). DBP is converted to GcMAF as a result of site-specific selective deglycosylation under the action of β-galactosidase and sialidase, localized on activated B and T cells, respectively. GcMAF exerts its biological activity primarily as the capability of activating macrophages by enhancing their phagocytic function and producing ROS. Activation results in elevated expression of the specific macrophageal surface receptors involved in the recognition of tumor-associated antigens, as well as in the implementation of direct anticancer activity by inducing the apoptosis or necrosis of tumor cells. Increased interest in GcMAF is associated with its potential to be used in the clinic as a new antitumor drug. Besides its anti-tumor activity, GcMAF exerts a potential against a number of viral and neurodegenerative diseases associated with increased activity of N-acetylgalactosaminidase (nagalase) in the blood serum of patients. Nagalase is an enzyme that completely (rather than selectively) deglycosylates DBP so it cannot be converted to GcMAF, leading to immunodeficiency. Circulating DBP is composed of unmodified and O-glycosylated molecules with the glycosylation degree being dependent on the allelic variants of the gene encoding DBP. The role of DBP in the resistance of organism against a number of diseases is supported by the increased risk of a variety of severe illnesses (amyotrophic lateral sclerosis, colorectal cancer etc.) in patients deficient for GcMAF due to homozygosity for defective DBP alleles. In this review, we also will examine in detail the current data i) on the structure and functions of DBP, as the main precursor of GcMAF, ii) on the main mechanisms of GcMAF anticancer effect, iii) on the tumor strategy for neutralizing GcMAF activity, iv) on the results of GcMAF clinical trials in various cancers; and will discuss the available controversies regarding the positioning of GcMAF as an effective antitumor drug.
Negative Interest Rate Risk. Atavism or Normalization of Central Banks’ Monetary Policy
Authors: Pyka Irena , Nocoń Aleksandra
Published: August 2019

In the face of the global financial crisis, central banks have used unconventional monetary policy instruments. Firstly, they implemented the interest rate policy, lowering base interest rates to a very low (almost zero) level. However, in the following years they did not undertake normalizing activities. The macroeconomic environment required further initiatives. For the first time in history, central banks have adopted Negative Interest Rate Policy (NIRP). The main aim of the study is to explore the risk accompanying the negative interest rate policy, aiming at identifying channels and consequences of its impact on the economy. The study verifies the research hypothesis stating that the risk of negative interest rates, so far unrecognized in Theory of Interest Rate, is a consequence of low effectiveness of monetary policy normalization and may adopt systemic nature, by influencing – through different channels – the financial stability and growth dynamics of the modern world economy.
Czy koncepcja sprawozdawczości zintegrowanej może być inspiracją dla nowego pragmatyzmu rachunkowości?
Authors: Kwiecień Mirosława
Published: August 2019

W publikacji przedstawiono dylematy związane z rachunkowością we współczesnej globalnej gospodarce. W dyskursach ekonomicznych jednoznacznie wskazuje się, że rachunkowość – jako technika transkrypcji – stanowi jedynie instrument do realizacji różnych celów. Czy my – rachunkowcy aprobujemy tę diagnozę? Czy wpłynęła ona na status rachunkowości jako nauki w polskim środowisku akademickim? Dlaczego finanse (a zwłaszcza ekonomia finansowa, która w ujęciu ilościowym, jakim były teoretyczne innowacje H. Markowitza, umożliwiła przekonanie zarządów funduszy inwestycyjnych, że ich portfele są wciąż tak samo bezpieczne, mimo że w rzeczywistości stawały się one coraz bardziej ryzykowne) nie poniosły konsekwencji jako dyscyplina naukowa? To trudne pytania, które były (i są) formułowane przez wielu reprezentantów nie tylko naszej dyscypliny naukowej, ale również przez wielu noblistów (np. J. Stiglitza i R. Schillera – wskazujących „słabości” teorii finansów, a zwłaszcza ekonomii, określanej często mianem ekonomii finansowej). Na podstawie analizy literatury naukowej (być może dokonałam dyskusyjnego jej wyboru) można zadać pytania o wartość predykcji teorii rachunkowości implikujących przewidywania faktów gospodarczych, nowy pragmatyzm rachunkowości, społeczną odpowiedzialność biznesu i zarządzanie ryzykiem w kontekście racjonalności w rozumieniu Arystotelesa, J. Kanta, M. Hellera i T. Kotarbińskiego. Celem artykułu jest wskazanie powodów, z jakich powinien rozpocząć się dyskurs o zmianie pragmatyzmu rachunkowości, aby ta możliwość – oprócz czysto logicznej – stała się realna. W publikacji zastosowano metodę analityczną badań, którą wspierano metodą indukcji i dedukcji.
Стручна звања у библиотечко-информационој делатности у Републици Србији
Authors: Стојановић Иван
Published: August 2019

Закон о библиотечкој делатности из 1994. године примењивао се у Србији више од две деценије и то у сложеним друштвено-политичким условима којима су свој печат дали дубока економска криза и рат. Истовремено, дошло је до великих промена у библиотечко-информационој делатности, првенствено изазваних наглим развојем информационо- комуникационих технологија. Нови закон је стога био нужан, али је донесен тек 2011. године. Заједно са новим одређењем библиотечко-информационе делатности, врста грађе и извора којима се она бави, промењена је и улога библиотекара. Тиме су и стручна звања поново постала предмет интересовања библиотечке јавности. У раду је приказан преглед прописа који се односе на њих, али и низ проблема и питања који су настали изменом правних аката. Посебна пажња посвећена је важећем Закону о библиотечко-информационој делатности и Правилнику о ближим условима за стицање виших стручних звања у библиотечко-информационој делатности који је из њега проистекао.
Допринос Универзитетске библиотеке „Светозар Марковић” сталном стручном усавршавању запослених у библиотечко-информационој делатности
Authors: Поповић Александра , Столић Драгана , Каваја Станишић Дејана
Published: August 2019

У раду је представљена едукативна активност Универзитетске библиотеке „Светозар Марковић” намењена запосленима у библиотечко-информационој делатности. Као матична за високошколске библиотеке на територији Србије, она се систематски и организовано бави стручним усавршавањем библиотекара у оквиру мреже академских библиотека. Успостављањем система акредитације у библиотечко-информационој делатности 2013. године, Библиотека је своју образовну делатност додатно развила, обогатила и унапредила, предлагањем и спровођењем значајног броја семинара које је похађао велики број корисника. У периоду од 2014. до 2018. године реализовано је 19 програма у којима је учествовало 2306 полазника. Досадашња пракса Библиотеке у овом сегменту рада указује на важност интерактивног, иновативног и флексибилног приступа обуци библиотечких радника, како би они лакше могли да савладају изазове са којима се суочавају, међу којима су сада најактуелнији: усвајање принципа отвореног приступа, разумевање основних појмова ауторског права, познавање нових информационих технологија значајних за библиотечке раднике и њихове све захтевније кориснике, коришћење комерцијалних и некомерцијалних електронских сервиса и сл.
Чикаго стил библиографског цитирања
Authors: Сабовљев Драгана
Published: August 2019

Цитирање као дословно навођење туђих речи, парафраза или резиме нечијих идеја или ставова у циљу потврђивања сопствених сазнања, полемике са супротним мишљењима, или као упућивање читаоца на сродне радове, захтева јасан и исцрпан библиографски опис извора. То подразумева правила по којима се наводе подаци о библиографској јединици која варирају од једног до другог стила цитирања. Избор зависи од научне дисциплине, правила која прописују часописи или зборници у којима се објављују радови, или од афинитета самих аутора. У овом тексту, на практичним примерима, представљенe су измене у начину цитирања појединих врста грађе и извора објављене у 17. издању Чикаго стила библиографског цитирања (Chicago Style) из 2017. године. Редакција Читалишта: научног часописа за теорију и праксу библиотекарства, у складу са традицијом заступљеном у часописима са тематиком из библиотечко-информационе делатности у свету, определила се за Notes and Bibliography style (односно Humanities Style). У овом тексту су приказани начини навођења различите библиотечко-информационе грађе и извора који се најчешће користе као референсна литература у научном или стручном раду.
THE KINGDOM OF SRIWIJAYA IN THE DEVELOPMENT OF ISLAMIC CIVILIZATION AND THE ECONOMY IN NUSANTARA BEFORE 1500 AD
Authors: Razzaq Abdur , Ridho Sari Lestari Zainal , Asmuni Asmuni
Published: August 2019

This study focuses attention on the history of the Sriwijaya Kingdom which is the oldest kingdom in the Malay Land and is considered as the kingdom with the greatest maritime power in the middle of the 7th century. As a former large empire, the inscriptions of the Sriwijaya Kingdom were valued by many researchers as very little compared to the kingdoms on Java. This makes it difficult for researchers when going to explore the traces of the history of standing and traces of his government. The expansion of the entire archipelago territory by the Sriwijaya Kingdom was not only in the context of expanding the territory but also had economic motives and controlled the international trade routes. This study also discusses the economic development, civilization, and the process of entry of Islam in Sriwijaya until the emergence of an Islamic political entity that came to be known as the Palembang Darussalam Sultanate.
LOCAL CULTURE OF MALAY AND UNIVERSAL CIVILIZATION CHANGES
Authors: Zed Mestika
Published: August 2019

Universal civilization changes occurred in the local Malay culture. Historically, the distinctive Malay society is united by a common race or Malay ethnic group. Based on the evidence of linguistics, archeology and history, the Malay identity is rooted and united by a common language, a primordial cultural pattern inherited from generation to generation. It includes "the myth stiffeners".
In Silico Analysis of Biomarker Potentials of miRNA-Mediated ceRNAs in Gastric Neoplasms
Authors: Us altay Diler , Ergün Sercan
Published: August 2019

Objectives: The objective of this study is to define novel biomarkers for gastric neoplasm (GN) via in silico analysis that takes GN-specific miRNAs, finds their combinatorial target genes (potential ceRNAs), selects ones containing  T-UCR among them and potentiates their relevance with GN. Based on this study we can plan new in vitro and in vivo studies.

Methods: Four miRNAs of which clinical relevances with GN were
proved experimentally were exported via mirTarbase. Using the ComiR database,
1008 genes targeted by these 4 miRNAs simultaneously were identified. Genes
containing T-UCR and showing potential ceRNA activity were extracted. Among
GN-associated ceRNAs including T-UCR, we identified genes with significant
expression differences between GN and normal stomach tissue using the GEPIA
database. The statistical evaluation of the association of NFAT5 and CLK3 genes with
GN was performed by Spearman correlation test in GEPIA database.

Results:
GN-associated ceRNAs cross-matching with genes including T-UCR in their exonic
regions were NFAT5 and CLK3. We identified genes with significant expression differences between
GN and normal stomach tissues among GN-associated ceRNAs including T-UCR.
According to this analysis, only NFAT5 gene
was significantly higher expressed in GN than in normal stomach tissue while
the other didn’t show any significant differential expression pattern. NFAT5 and CLK3 genes were found to be significantly correlated with GN
(p<0.001; R=0.22)

Conclusion:
All in all, this is the study associating NFAT5
gene with GN for the first time and giving it ongogenic potential for GN.
Still, larger and more comprehensive studies are needed on this issue.
The Clinical Predictive Value of the Neutrophil to Lymphocyte Ratio as a Biomarker in Lumbar Disc Herniation
Authors: YILMAZ Ali , ALTAŞ Hilal , YILDIRIM Timur , KAYGISIZ Şükran , IŞIK Hasan Serdar
Published: August 2019

Objective: Low back pain is a frequently seen problem in the society and causes loss
of labor. Although etiology of lumbar disc herniation is multi-factorial it is
known that it is determinant for the etiology of intervertebral disc
degeneration herniation. In recent studies, it has been shown that it has an
efficient role in the process of inflamation and inflamatory cytokine disc. We
aimed to investigate the association between the neutrophil to Lymphocyte Ratio  level as an inflammatory biomarker in
patients with lumbar disc herniation.

Methods: 394 patients between the age
of 18-80 applying to our center because of low back pain complaint and having
lumbar MR were included in the study. The patients were divided into two groups
as having lumbar disc hernia and not having based on the lumbar MR result.
Blood samples were taken from all patients during application and neutrophil lymphocyte
rates were calculated. 

Results.  Average age of group with lumbar disc hernia
was 46 and 55 of these cases were female and 45 of them were male. N/L rate was
measured as 3.81+/-1.85 (p=0.001) in the group having lumbar disc hernia and
significant difference compared to the control group was noted. It was found
out that lifting weight (β=0.121 95% Cl (0.052-0.281), P<0.001),BMI
(β=0.226, 95% Cl (0.080-0.640) P=0.005), DM (β=0.268 95% Cl (0.074-0.969),
P=0.045), smoking (β=3.226 95% Cl (1,343-7.749), P<0.009), educational
background (β=5.268 95% Cl (1.941-9.796), P=0.001) and NLR (β=1.302 95% Cl
(1.013-1.673), P=0.039) were the independent predictors in the presence of
lumbar disc herniation.

Conclusion:
NLR may be used as a simple and reliable premise independent predictor of
lumbar disc herniation in patients with low back pain.
Detección de enterobacterias productoras de β-lactamasas de espectro extendido (BLEE) aisladas en carne molida de supermercados de un distrito de Lima, Perú
Authors: Cortez Sandoval Valeria , Shiva Ramayoni Carlos
Published: August 2019

El objetivo del estudio fue detectar la presencia de enterobacterias productoras de β-lactamasas de espectro extendido (BLEE), aisladas de carne molida, proveniente de recortes de res que se comercializan en supermercados de un distrito de Lima, Perú. Se recolectaron muestras de 50 gramos de carne molida de 10 tiendas de 5 cadenas de supermercados, las que se procesaron en el Laboratorio de Nutrición e Inocuidad Alimentaria de la Facultad de Medicina Veterinaria y Zootecnia de la Universidad Peruana Cayetano Heredia. Se realizaron diluciones para cada muestra y se sembraron en Agar EMB. A través de baterías de bioquímica comercial se identificaron las especies de enterobacterias. Se utilizaron dos métodos para evidenciar el patrón BLEE, el primero para determinar cepas sospechosas (método de difusión simple en agar) y el segundo para confirmar la producción de BLEE (método de doble disco). Se aislaron 38 cepas de enterobacterias, resultando el 28,94% (11) sospechosas de producir BLEE para los antibióticos cefotaxima, ceftazidima, ceftriaxona, aztreonam y cefpodoxima bajo el método de difusión simple. Resultando positivas a BLEE por método de doble disco el 15,79% (6) a los mismos antibióticos más amoxicilina con ácido clavulánico. Se pone en evidencia que la carne molida comercializada en supermercados puede contener cepas productoras de BLEE, siendo las especies de enterobacterias más frecuentes Citrobacter freundii, Serratia marcescens, Yersinia enterocolitica, Citrobacter braakii y Enterobacter cloacae.
Efecto del nivel proteico dietario sobre el tamaño de camada y ganancia de peso total en crías de cuyes raza andina
Authors: Paco Carlos , Echevarría Luisa
Published: August 2019

El objetivo del estudio fue evaluar el efecto de tres niveles dietarios de proteína (12 g/100 g PC, 17g/100g PC y 22 g/100g PC) sobre el número de crías nacidas, el peso de la camada al nacimiento y al destete, y la ganancia de peso total de la camada. Se utilizaron cuyes de raza Andina debido a su precocidad y prolificidad. Las hembras recibieron 50 gramos diarios de las dietas experimentales desde 16 días previos al empadre. Durante el empadre, recibieron la dieta experimental solo durante el día (08:00 – 14:00 hrs) por 32 días. Finalmente, fueron alimentadas con la misma ración experimental desde la gestación hasta la época del destete (14 días postparto). Los resultados demostraron que no existe un efecto significativo del nivel proteico de la dieta sobre el número de crías nacidas y pesos totales de camada, sin embargo, para los pesos al destete y ganancia total diaria, la dieta normoproteica (17 g/100 g) ofreció mejores resultados (p<0,05).
Indicadores demográficos y estimación de la población de canes en el distrito de Bellavista, Callao – Perú
Authors: Harada César , León Daphne , Gamarra Norma , Falcón Néstor
Published: August 2019

El estudio tuvo como objetivo estimar indicadores demográficos y la población de canes con dueño en el distrito de Bellavista, Callao. Se utilizó una encuesta como herramienta de recolección de información, la que fue aplicada en las viviendas del distrito, las que fueron seleccionadas a partir de un muestreo bietápico. Se seleccionó una muestra del 20% de las manzanas de cada zona, siguiendo un muestreo sistemático. Asimismo, en cada zona se seleccionaron 10 viviendas a encuestar. Las características demográficas de la población de canes se resumieron mediante estadística descriptiva. Se encontró que el 56,1% de hogares poseían al menos un can. El promedio de canes, entre las viviendas que tenían canes, fue de 1,6. Se encontró una relación humano: can de 5,6: 1. La edad promedio de los canes fue de 5,4 años. La población de machos representaba el 50,2% del total, mientras que las hembras representaban el 49,8%. La proporción de animales que se encontraban esterilizados o castrados fue del 19,2%. Con los resultados encontrados en este estudio las autoridades competentes del distrito serán capaces de optimizar la planificación de las campañas antirrábicas, así como los programas de tenencia responsable de animales de compañía.
Evaluación de la efectividad del fipronil al 1% e ivermectina al 1% en el tratamiento de la sarna por Trixacarus caviae en cuyes (Cavia porcellus).
Authors: Huamán Meylin , Leguia Guillermo , Chauca Lilia , Torres Luis , Falcón Néstor
Published: August 2019

El objetivo del estudio fue evaluar la efectividad del fipronil al 1% y de la ivermectina al 1% en el tratamiento de sarna causada por Trixacarus caviae en cuyes infestados naturalmente, durante un periodo de 42 días. Para ello se seleccionaron 21 hembras reproductoras, dividiéndose al azar en tres grupos: (a) tratado con fipronil (vía epicutánea) 1,5 ml/kg. p.v., (b) tratado con ivermectina (vía subcutánea) 0,05 ml/kg. p.v. ambos con cuatro tratamientos a intervalos de 8 días, y (c) sin tratamiento. Cada 8 días se colectó escarificaciones cutáneas de cada animal para determinar el porcentaje de ácaros vivos y se tomaron biopsias de piel de un animal por grupo para la evaluación histopatológica. Al inicio del estudio los cuyes de los tres grupos presentaron 100% de ácaros vivos, observándose al día 42 post tratamiento, una disminución de ácaros vivos hasta 11,1% en el grupo tratado con fipronil y hasta 0% en el grupo tratado con ivermectina. La efectividad que alcanzó el fipronil fue de 95,2% y la ivermectina 100%, no encontrándose diferencia significativa entre ellas, pero sí con respecto al grupo control. La evolución de la recuperación histopatológica en ambos grupos tratados fue similar al día 42, observándose ausencia de infiltrado inflamatorio y la mayoría de folículos pilosos eran viables. Se concluye que el fipronil y la ivermectina, ambos al 1%, aplicados en cuatro dosis consecutivas con intervalos de 8 días mostraron un efecto acaricida sobre el T. caviae.
SOCIAL SUPPORT TO TEENAGER BREAKFAST BEHAVIOR (Study at Sidoarjo Islamic State Senior High School)
Authors: Prayogo Angga Satria , Sulistyowati Muji
Published: August 2019

Background: Breakfast is an important activity for people of all ages, including teenagers, before starting their daily activities. There are many benefits of breakfast that can be felt by the body, but some studies showed that some teens have a poor breakfast habit. Purpose: This research was conducted to analyze the effect of social support on breakfast behavior in teenager in the Sidoarjo Islamic State Senior High School (SHS). Methods: This study was an analytic observational study with cross-sectional. The population of this study were 906 teenagers of 11th and 12th grade who were registered as active students in Sidoarjo Islamic State SHS in 2018/2019, while for the sample were 442 teenagers in that school who were willing to be respondents of the study. The sample was taken through cluster random sampling technique. Results: The results showed that 44.1% of respondents had moderate breakfast behavior and 53.8% of respondents had high social support to have breakfast. Good breakfast behavior tends to be more owned by respondents who have high social support, which is 35.3%. Based on the ordinal regression test results, there is an influence of social support on breakfast behavior in teenagers at Sidoarjo Islamic State SHS with Sig. = 0.011. Parents tend to give big contribution to breakfast behavior in teenagers in Sidoarjo Islamic State SHS, namely giving idea of having breakfast, preparing food for breakfast, telling them to have breakfast, and explaining the importance of having breakfast so that the form of social support from parents already includes emotional, informational, instrumental, and appreciation support. Friends also have a contribution to breakfast behavior in teenagers even though it only includes emotional support (explaining the importance of having breakfast) and informational (explaining the importance of having breakfast). Conclusion: The conclusion of this study is social support from parents and friends can influence breakfast behavior in teenagers in Sidoarjo Islamic State SHS.
HUBUNGAN PENGETAHUAN, SIKAP DAN PERSEPSI IBU DENGAN STATUS IMUNISASI DASAR DI WONOKUSUMO
Authors: Dillyana Tri Anisca
Published: August 2019

Background: Basic immunization is the first immunization that should be given to everyone, especially infants and children from birth to protect lifes from dangerous diseases. The immunization program in Indonesia requires every infant (0-11 months) to receive complete basic immunization consist of 1 dose of Hepatitis B, 1 dose of BCG, 3 doses of DPT-HB-Hib, 4 doses of polio, and 1 dose of measles. Basic Immunization in RW 8 Wonokusumo Urban Village in 2017 has not reached the target. Only 73 infants (67%) of 108 have received complete basic immunization which the target of Puskesmas is 95%. This study aims to know the correlation of knowledge, attitude and mother perception with the basic immunization status in Wonokusumo. This study is an observational analytic research with quantitative approach. The study was cross sectional with a sample of 39 respondents. The sampling technique used is purposive sampling. Respondents in this study are mothers who have children under three and have KMS in RW 8 Wonokusumo Urban Village. Primary data collection techniques obtained from questionnaires while secondary data obtained from Wonokusumo Puskesmas and Surabaya City Health Office reports .The result of bivariate statistic test shows that there is correlation between knowledge, attitude, and mother perception with the immunization status of children under three with p = 0,001 (p < 0,05). Conclusion: There is correlation between knowledge, attitude, and mother perception with the basic immunization status in RW 8, Wonokusumo Village.
GAMBARAN PELAKSANAAN PELAYANAN KESEHATAN PEDULI REMAJA (PKPR) DI PUSKESMAS DUPAK SURABAYA
Authors: Avilla Tamara
Published: August 2019

Background: Adolescent health services is one of the government programs aimed at teenagers in Indonesia with the intention that teenagers have a comfortable place to grip or help deal with all sorts of teenage problems that are being faced. This PKPR is implemented in every Health Care. Purpose: the aims of this study was seen implementation  PKPR in Dupak Health Care, Surabaya. Methods: This study was conducted at Dupak Health Care, Surabaya using qualitative descriptive research with observation method and in-depth interview at Head of Dupak Health Care Surabaya, holder of UKBM program (The Effort of Health Community Based Services) in Health Care, PKPR program holder, and some teenagers working area of Health Care. Results: The results and discussion in this journal that describes the implementation of health care services adolescents at Puskesmas Dupak Surabaya Health Center by adjusting the reference of National Standard PKPR 2014 and in line with previous similar research. Conclusion: There is a mismatch between the implementation of PKPR and the national standard of health care for adolescents that is influenced by various factors.
Gut-Microbiota-Brain-Axis, Leaky Gut, Leaky Brain: Pathophysiology of Second Brain Aging and Alzheimer’s disease- A Neuroscientific Riddle
Authors: Bilal Ahmad
Published: August 2019

Alzheimer’s disease (AD) is one of the most common neurodegenerative illnesses. However, how Gut-Microbiota plays a role in the pathogenesis of AD is not well elucidated. The purpose of this literature review is to summarize and understand the current findings that may elucidate the gut microbiota role in the pathogenesis of AD. A literature review of all the relevant papers knows to the author was conducted. Relevant articles, abstracts and research papers were collected from well-accepted web sources like PubMed, PMC, and Google Scholar. Recent studies have shown that Gut-microbiota has an important role in the progression of AD, via Gut-Microbiota-Brain Axis. The onset of AD supports ‘Hygiene Hypothesis’ which showed that AD may begin in the Gut causing dysbiosis which interferes with intestinal barrier by releasing pro-inflammatory cytokines and makes it way up to the brain via Blood-Brain-Barrier (BBB). Molecular mechanisms lipopolysaccharides and serotonin kynurenine (tryptophan) pathways have a direct association with inflammation, immune system, neurodegeneration, and AD. The studies focusing on the second brain aging of the intestine, dysbiosis, and the ultimate complications of dysbiosis link to the brain via Gut-brain axis. This review will summarize the current findings on gut-microbiota and second brain aging which have crucial role in neurodegeneration and Alzheimers disease. Which further studies to explore the therapeutic effects of probiotics in AD and cognitive enhancement should be warranted to provide significant clinical and practical value.
In vitro Callus Cultures for Enhanced Production of Flavonoid (Quercetin) Content, its Analysis and Antibacterial Activity of Nyctanthes arbortristis
Authors: Ruchita Shrivastava  , Ajay Kumar Bharadwaj
Published: August 2019

Flavonoids have stirred extensive intrigue in light of their potential helpful impact on human wellbeing. Quercetin is a standout amongst the most copious regular flavonoids present in therapeutic plants. The present study was planned to study the in vitro production of flavonoids in callus culture of Nyctanthes arbortristis using different plant growth regulators, and screening of antibacterial activity of ethanol extract of leaves. The callus was produced by transferring the sterile leaves on MS medium containing different concentration of cytokinins like 0.5 mg/l BAP (6-benzylaminopurine), 1.0 mg/l KN (kinetin) with auxins like 0.5 - 2.0 mg/l 2,4-D (2 4-dichlorophenoxyacetic acid). The petroleum ether, ethanol and aqueous extracts of Nyctanthes arbortristis leaves and callus were prepared. The content of quercetin in plant extract and callus extract were performed by HPLC. The antibacterial activity of ethanol extract of leaves were performed by using agar well diffusion and spectroscopy antibacterial activity method. The phytochemical study uncovered the nearness of different secondary metabolites in various extract of plant. The HPLC study confirmed the presence of methoxylated flavonoid quercetin-3,3’-dimethoxy-7-0-rhamnoglucopyranose as a active component in extract. The callus contained higher amount of quercetin compared to fresh leaves. The antibacterial screening results showed that ethanol extract of Nyctanthus arbortristis leaves has been observed an efficient antibacterial effect against different microbes namely S. aureus, E.  coli, S. epidermidis and P. aeruginosa.
Antiulcer and Antihyperlipidaemic Efficacy of Catharanthus roseus Leaves on pylorus ligation induced Ulcer in Experimental Animals
Authors: Pahadiya Anitakumari Rambhai  , Dr. S.S. Sisodia  , Arijit Chaudhuri  , Arpit Patidar
Published: August 2019

The present study was undertaken to scientifically validate the antiulcer and antihyperlipidaemic activity of leaves of Catharanthus roseus against pylorus ligation induced gastric ulcer in experimental animals. The methanol extract of leaves were prepared, and phytochemical analysis of extract were performed. The antiulcer activity as seen by the area of gastric volume, free acidity, total acidity, pH, percentage of ulcer protection and ulcer index were estimated. The antihyperlipidaemic activity with following parameters cholesterol, high density lipoprotein (HDL), Triglycerides (TGL), low density lipoprotein (VLDL), Cholesterol/HDL and low density lipoprotein (LDL) were also evaluated. The phytochemical analysis of methanol extract of leaves of Catharanthus roseus demonstrated the presence of flavonoids, alkaloids, steroids, glycosides and saponin. The extract (125, 250 and 500 mg/kg) and standard drug treated animals significantly decreased the gastric volume, total acidity, free acidity and ulcer index; and  pH of the gastric juice was significantly increased compared to ulcer control group. The extract and standard drug treated rats significantly decreased in TGL, total cholesterol, VLDL, Cholesterol/HDL and LDL, and increased HDL compared to ulcer induced control group rats. The above finding suggests the antiulcer and antihyperlipidaemic activity of Catharanthus roseus extracts.
Entrepreneurial opportunity discovery dimensions and growth of non-governmental organizations in Kenya
Authors: Ndeveni Olive Kamane , Wanjau Kenneth Lawrence , Kariuki George Mbugua , Muchiri Joseph
Published: August 2019

Non-Governmental Organizations (NGOs) play a critical role in addressing social ills like poverty, employment, and food insecurity; therefore, their growth prospects enhance their ability to address these social ills. Discovery of entrepreneurial opportunities amongst the agro-based NGOs has not got the desired attention, and it is the least researched area in social entrepreneurship. This study investigated the relationship between Entrepreneurial Opportunity Discovery Dimensions and Growth of Non-Governmental Organizations in Kenya. It employed correlation design and was anchored on the Kirznerian Entrepreneurship Theory. The target population was 135 agro-based NGOs in Kenya. A mixed-method approach was used, combined qualitative and quantitative techniques. Statistical Package for Social Sciences (SPSS) version 21 and Analysis of Moment Structures (AMOS graphic-25) aided in the analysis. Structural Equation Modeling (SEM) using AMOS and Simple linear regression analysis were the primary analysis techniques used to evaluate the relationship between entrepreneurial opportunity discovery dimensions and the growth of NGOs. The results indicated that alertness0.372, p=0.033)and prior knowledge (0.163, p=0.031) have a significant favorable influence on growth, while social networks 0.047, p=0.713) showed an insignificant effect on the growth of NGOs. Investing in acquiring alert individuals and helping them gain relevant knowledge in the 21sttechnologies and emerging issues can lead to increased NGO ability to continue serving the community effectively and be engines of development for the general good of Kenya.
Effect of work ethics on job performance with adversity quotient as a mediator
Authors: Runtu Delon , Aldrin Neil , Merdiaty Netty
Published: August 2019

This study examines the importance of work ethics for employees in the organization towards performance achievement by bringing up the role of adversity quotient mediator. The study aimed to investigate and explore the direct and indirect influence through mediators by using path analysis techniques with the help of AMOS version 24. The process of data collection was carried out using three research variable scales. The number of research respondents is 220 employees. The results of the analysis prove four hypotheses that have been shown to have direct influence, and the role of the mediator is perfect in mediating the two variables. The results of this study can be useful for organizations and practitioners of psychology in industry and organizations.