bluuebunny/crossref_metadata_2025 huggingface dataset:
Mixed-state entanglement and information recovery in thermalized states and evaporating black holes
Authors: Vardhan Shreya , Kudler-Flam Jonah , Shapourian Hassan , Liu Hong
Published: January 2023

Abstract

We study the universal behavior of quantum information-theoretic quantities in thermalized isolated quantum many-body systems and evaporating black holes. In particular, we study a genuine mixed-state entanglement measure called the logarithmic negativity, other correlation measures including the Renyi negativities and the mutual information, and a signature of multipartite entanglement called the reflected entropy. We also probe the feasibility of recovering quantum information from subsystems of a thermalized quantum many-body system or from the radiation of an evaporating black hole, using quantities such as relative entropy and Petz map fidelity. A recently developed technique called the equilibrium approximation allows us to probe these quantities at finite temperature. We find striking qualitative differences from the infinite temperature case, which has been the topic of previous studies using Haar-random states. In particular, we find regimes where the logarithmic negativity is extensive but the mutual information is sub-extensive, indicating a large amount of undistillable, bound entanglement in thermalized states. For evaporating black holes at finite temperature, both the logarithmic negativity and the Petz map fidelity reveal an important new time scale tb, which is earlier than the Page time tp by a finite fraction of the total evaporation time. We find that tb, as opposed to tp, is the time scale at which quantum entanglement between different parts of the radiation becomes extensive, and the fidelity of information recovery for a large diary thrown into the black hole starts to grow.
Reflected entropy in random tensor networks. Part II. A topological index from canonical purification
Authors: Akers Chris , Faulkner Thomas , Lin Simon , Rath Pratik
Published: January 2023

Abstract

In ref. [1], we analyzed the reflected entropy (SR) in random tensor networks motivated by its proposed duality to the entanglement wedge cross section (EW) in holographic theories, $$ {S}_R=2\frac{EW}{4G} $$

S
R

=
2

EW

4
G

. In this paper, we discover further details of this duality by analyzing a simple network consisting of a chain of two random tensors. This setup models a multiboundary wormhole. We show that the reflected entanglement spectrum is controlled by representation theory of the Temperley-Lieb algebra. In the semiclassical limit motivated by holography, the spectrum takes the form of a sum over superselection sectors associated to different irreducible representations of the Temperley-Lieb algebra and labelled by a topological index k ∈ ℤ>0. Each sector contributes to the reflected entropy an amount $$ 2k\frac{EW}{4G} $$
2
k

EW

4
G

weighted by its probability. We provide a gravitational interpretation in terms of fixed-area, higher-genus multiboundary wormholes with genus 2k – 1 initial value slices. These wormholes appear in the gravitational description of the canonical purification. We confirm the reflected entropy holographic duality away from phase transitions. We also find important non-perturbative contributions from the novel geometries with k ≥ 2 near phase transitions, resolving the discontinuous transition in SR. Along with analytic arguments, we provide numerical evidence for our results. We finally speculate that signatures of a non-trivial von Neumann algebra, connected to the Temperley-Lieb algebra, will emerge from a modular flowed version of reflected entropy.
Cardiovascular outcomes in type 1 and type 2 diabetes
Authors: Rosengren Annika , Dikaiou Pigi
Published: January 2023

Diabetes is one of the most prevalent cardiometabolic disorders on the planet. Type 1 diabetes accounts for only a minority of all cases (recently estimated to be ~2% globally); however, since this is a disorder with an early onset, many people live with type 1 diabetes for a long time. CVD and premature death are the main long-term outcomes for both types of diabetes; however, the type of diabetes that carries the highest risk of these outcomes is a controversial topic and has not been widely studied. Because of the association between diabetes and CVD, the rise in type 2 diabetes prevalence over the past decades has huge effects on global health. The excess risk in people with diabetes compared with those without depends, to a large extent, on the presence of other factors, such as general cardiovascular risk factors (e.g. elevated LDL-cholesterol, hypertension and smoking) and also factors that are more specific to diabetes (e.g. HbA1c, and micro- and macroalbuminuria). Some contributory factors are modifiable, while others are not, such as age, sex and type of diabetes. Older people with type 2 diabetes who have risk factors that are under control can achieve levels of CVD risk that are similar to that of the general population, while younger individuals with type 1 diabetes are mostly unable to achieve similar levels of risk, probably because of long and cumulative exposure to raised blood glucose levels. Despite reports of declining rates of CVD among people with type 1 and type 2 diabetes, rising rates of both types of diabetes lead to a continuing rise in the number of people with cardiometabolic disorders worldwide, offsetting the progress made in many countries. Comparison between individuals with type 1 and type 2 diabetes with respect to risk of CVD is fraught with difficulties and highly dependent on other, concomitant factors, some of which are modifiable and others not. Nonetheless, as a whole, what matters most in determining the management of diabetes is absolute risk and lifetime risk. Life-long efforts to achieve glycaemic control, control of lipids and hypertension, and not smoking are key to prevention, with a healthy lifestyle and pharmacological therapy to be implemented as needed.

Graphical abstract
Use of red grape pulp, marc and must in the production of beer
Authors: Cioch-Skoneczny Monika , Sral Anna , Cempa Arkadiusz , Rzadkowska Justyna , Satora Paweł , Skoneczny Szymon
Published: January 2023

The aim of the paper was to determine the potential of using grape pulp, marc and must in the beer production process. Samples were fermented using non-Saccharomyces yeasts (Dekkera bruxellensis 3429, Metschnikowia pulcherrima MG970690), while Saccharomyces cerevisiae Safale US-05 was used as a control. Grape marc was obtained by pressing grape must. The grape marc, must and pulp were pasteurized and, together with wort, volumetrically introduced into fermentation flasks for fermentation. Mass changes taking place during the process were analyzed. Real extract, alcohol content, free amino nitrogen (FAN) content, titratable acidity, pH, color, organic acid profile and content of sugars were determined in obtained beers. The addition of grape marc, must and pulp increased the value of most of the tested parameters. It did not adversely affect the fermentation process. This offers the possibility of using grape marc, must and pulp in the brewing industry, even with the use of non-Saccharomyces yeast monocultures.
Between-group variation in production of pant-grunt vocalizations by wild bonobos (Pan paniscus)
Authors: Schamberg Isaac , Clay Zanna , Townsend Simon W. , Surbeck Martin
Published: January 2023

The potential for aggression is inherent in social interaction, and strategies to reduce the costs of aggression are ubiquitous among group-living animals. One strategy employed by lower-ranking individuals in a variety of species is the production of subordination signals, which are formal signals that communicate the signaler’s inferior status relative to the recipient of the signal. Here, we report the results of our investigations into (1) the presence and usage of the pant-grunt vocalization in two populations of wild bonobos; (2) the relationship between the production of pant-grunts and agonistic predictability across the genusPan. We find stark differences in production of pant-grunts in the two populations: bonobos at the LuiKotale field site regularly used pant-grunts as a signal of subordination (primarily, though not exclusively, among male-male dyads); in contrast, at the Kokolopori field site, adult bonobos were never observed producing pant-grunts. AcrossPan, we find weak support for an association between agonistic predictability and production of pant-grunt vocalizations.

Significance statement

There have been conflicting reports on whether bonobos, like chimpanzees, produce the submissive pant-grunt vocalization. We confirm the presence of the pant-grunt in the bonobo vocal repertoire, and document variation in its production across communities. We also suggest that variation in pant-grunt production across the genusPanmay be explained by the predictability of dominance interactions.
Validation of a semi-automatic method to measure total liver volumes in polycystic liver disease on computed tomography — high speed and accuracy
Authors: Aapkes Sophie E. , Barten Thijs R. M. , Coudyzer Walter , Drenth Joost P. H. , Geijselaers Ivo M. A. , ter Grote Sterre A. M. , Gansevoort Ron T. , Nevens Frederik , van Gastel Maatje D. A.
Published: January 2023

Objectives

Polycystic liver disease (PLD) is characterized by growth of hepatic cysts, causing hepatomegaly. Disease severity is determined using total liver volume (TLV), which can be measured from computed tomography (CT). The gold standard is manual segmentation which is time-consuming and requires expert knowledge of the anatomy. This study aims to validate the commercially available semi-automatic MMWP (Multimodality Workplace) Volume tool for CT scans of PLD patients.

Methods

We included adult patients with one (n = 60) or two (n = 46) abdominal CT scans. Semi-automatic contouring was compared with manual segmentation, using comparison of observed volumes (cross-sectional) and growth (longitudinal), correlation coefficients (CC), and Bland-Altman analyses with bias and precision, defined as the mean difference and SD from this difference. Inter- and intra-reader variability were assessed using coefficients of variation (CV) and we assessed the time to perform both procedures.

Results

Median TLV was 5292.2 mL (IQR 3141.4–7862.2 mL) at baseline. Cross-sectional analysis showed high correlation and low bias and precision between both methods (CC 0.998, bias 1.62%, precision 2.75%). Absolute volumes were slightly higher for semi-automatic segmentation (manual 5292.2 (3141.4–7862.2) versus semi-automatic 5432.8 (3071.9–7960.2) mL, difference 2.7%, p < 0.001). Longitudinal analysis demonstrated that semi-automatic segmentation accurately measures liver growth (CC 0.908, bias 0.23%, precision 4.04%). Inter- and intra-reader variability were small (2.19% and 0.66%) and comparable to manual segmentation (1.21% and 0.63%) (p = 0.26 and p = 0.37). Semi-automatic segmentation was faster than manual tracing (19 min versus 50 min, p = 0.009).

Conclusions

Semi-automatic liver segmentation is a fast and accurate method to determine TLV and liver growth in PLD patients.

Key Points

• Semi-automatic liver segmentation using the commercially available MMWP volume tool accurately determines total liver volume as well as liver growth over time in polycystic liver disease patients.

• This method is considerably faster than manual segmentation through the use of Hounsfield unit settings.

• We used a real-life CT set for the validation and showed that the semi-automatic tool measures accurately regardless of contrast used for the CT scan or not, presence of polycystic kidneys, liver volume, and previous invasive treatment for polycystic liver disease.
The effect of citicoline oral solution on quality of life in patients with glaucoma: the results of an international, multicenter, randomized, placebo-controlled cross-over trial
Authors: Rossetti Luca , Goni Francisco , Montesano Giovanni , Stalmans Ingeborg , Topouzis Fotis , Romano Dario , Galantin Eleonora , Delgado-Gonzales Noemi , Giammaria Sara , Coco Giulia , Vandewalle Evelien , Lemmens Sophie , Giannoulis Dimitrios , Pappas Theofanis , Manni Gianluca
Published: January 2023

Purpose

This study aims to evaluate whether the use of citicoline oral solution could improve quality of life in patients with chronic open-angle glaucoma (OAG).

Design

Randomized, double-masked, placebo-controlled, cross-over study was used. Patients were randomized to one of the two sequences: either citicoline 500 mg/day oral solution-placebo or placebo-citicoline 500 mg/day oral solution. Switch of treatments was done after 3 months; patients were then followed for other 6 months. Follow-up included 3-month, 6-month, and 9-month visits.

Outcomes

The primary outcome was the mean change of “intra-patient” composite score of the Visual Function Questionnaire-25 (VFQ-25). after citicoline oral solution vs placebo at 6-month visit as compared with baseline.

Methods

The trial was multicenter, conducted at 5 European Eye Clinics. OAG patients with bilateral visual field damage, a mean deviation (MD) ranging from − 5 to − 13 dB in the better eye, and controlled IOP were included. VFQ-25 and SF-36 questionnaires were administered at baseline and at 3-, 6-, and 9-month visits. A mixed effect model, with a random effect on the intercept, accounted for correlations among serial measurements on each subject.

Results

The primary pre-specified outcome of the analysis reached statistical significance (p = 0.0413), showing greater improvement after citicoline oral solution. There was an increase in the composite score in both arms compared to baseline, but it was significant only for the placebo-citicoline arm (p = 0.0096, p = 0.0007, and p = 0.0006 for the three time-points compared to baseline). The effect of citicoline was stronger in patients with vision-related quality of life more affected by glaucoma at baseline.

Conclusions

This is the first placebo-controlled clinical study evaluating the effect of a medical treatment aiming at improving vision-related quality of life in glaucomatous patients.
Surgical treatment for pancreatic cystic lesions—implications from the multi-center and prospective German StuDoQ|Pancreas registry
Authors: Henn Jonas , Wyzlic Patricia K. , Esposito Irene , Semaan Alexander , Branchi Vittorio , Klinger Carsten , Buhr Heinz J. , Wellner Ulrich F. , Keck Tobias , Lingohr Philipp , Glowka Tim R. , Manekeller Steffen , Kalff Jörg C. , Matthaei Hanno ,   the StuDoQ|Pancreas Study Group
Published: January 2023

Purpose

The detection of pancreatic cystic lesions (PCL) causes uncertainty for physicians and patients, and international guidelines are based on low evidence. The extent and perioperative risk of resections of PCL in Germany needs comparison with these guidelines to highlight controversies and derive recommendations.

Methods

Clinical data of 1137 patients who underwent surgery for PCL between 2014 and 2019 were retrieved from the German StuDoQ|Pancreas registry. Relevant features for preoperative evaluation and predictive factors for adverse outcomes were statistically identified.

Results

Patients with intraductal papillary mucinous neoplasms (IPMN) represented the largest PCL subgroup (N = 689; 60.6%) while other entities (mucinous cystic neoplasms (MCN), serous cystic neoplasms (SCN), neuroendocrine tumors, pseudocysts) were less frequently resected. Symptoms of pancreatitis were associated with IPMN (OR, 1.8; P = 0.012) and pseudocysts (OR, 4.78; P < 0.001), but likewise lowered the likelihood of MCN (OR, 0.49; P = 0.046) and SCN (OR, 0.15, P = 0.002). A total of 639 (57.2%) patients received endoscopic ultrasound before resection, as recommended by guidelines. Malignancy was histologically confirmed in 137 patients (12.0%), while jaundice (OR, 5.1; P < 0.001) and weight loss (OR, 2.0; P = 0.002) were independent predictors. Most resections were performed by open surgery (N = 847, 74.5%), while distal lesions were in majority treated using minimally invasive approaches (P < 0.001). Severe morbidity was 28.4% (N = 323) and 30d mortality was 2.6% (N = 29). Increased age (P = 0.004), higher BMI (P = 0.002), liver cirrhosis (P < 0.001), and esophageal varices (P = 0.002) were independent risk factors for 30d mortality.

Conclusion

With respect to unclear findings frequently present in PCL, diagnostic means recommended in guidelines should always be considered in the preoperative phase. The therapy of PCL should be decided upon in the light of patient-specific factors, and the surgical strategy needs to be adapted accordingly.
Molecular characterization of Dictyocaulus nematodes in wild red deer Cervus elaphus in two areas of the Italian Alps
Authors: Cafiso Alessandra , Castelli Michele , Tedesco Perla , Poglayen Giovanni , Pederzoli Clelia Buccheri , Robetto Serena , Orusa Riccardo , Corlatti Luca , Bazzocchi Chiara , Luzzago Camilla
Published: January 2023

Nematodes of the genus Dictyocaulus are the causative agents of parasitic bronchitis and pneumonia in several domestic and wild ungulates. Various species have been described in wild cervids, as the case of Dictyocaulus cervi in red deer, recently described as a separate species from Dictyocaulus eckerti. In Italy, information on dictyocaulosis in wildlife is limited and often outdated. In this work, 250 red deer were examined for the presence of Dictyocaulus spp. in two areas of the Italian Alps (n = 104 from Valle d’Aosta, n = 146 from Stelvio National Park), and the retrieved lungworms were molecularly characterized. Lungworms were identified in 23 and 32 animals from Valle d’Aosta and Stelvio National Park, respectively. The nematodes, morphologically identified as D. cervi, were characterized molecularly (18S rDNA, ITS2, and coxI). Consistently, almost all specimens were found to be phylogenetically related to D. cervi. Three individuals, detected from both study sites and assigned to an undescribed Dictyocaulus sp., clustered with Dictyocaulus specimens isolated from red deer and fallow deer in previous studies. Within each of D. cervi and the undescribed Dictyocaulus sp., the newly isolated nematodes phylogenetically clustered based on their geographical origin. This study revealed the presence of D. cervi in Italian red deer, and an undetermined Dictyocaulus sp. that should be more deeply investigated. The results suggest that further analyses should be focused on population genetics of cervids and their lungworms to assess how they evolved, or co-evolved, throughout time and space and to assess the potential of transmission towards farmed animals.
On the Effect of Shield Friction in Hard Rock TBM Excavation
Authors: Erharter Georg H. , Goliasch Robert , Marcher Thomas
Published: January 2023

During hard rock tunnel boring machine (TBM) excavation, shields behind the cutterhead are usually in direct contact with the tunnel wall and therefore subjected to friction forces that occur within this interface. The effect of shield friction in hard rock TBM tunneling has received little attention so far and literature on this topic is scarce and conflicting. To investigate the friction coefficient for the planning of TBM excavations, specialized shear tests were conducted where steel specimens were sheared against lithologically different rock specimens under representative normal forces and shearing speeds. The tests were executed with and without the use of bentonite lubrication. The results show that there is a significant difference between different lithologies and also that using bentonite does not lower the friction coefficient as expected. To elaborate on the effect of shield friction during construction, a framework for interpretation of TBM operational data based on experience from construction sites is provided. Whereas thorough interpretation of the data enables one to draw conclusions about the shield friction, it still remains difficult to assess the real effect of shield friction due to the limited possibilities to observe the ongoing phenomena. This study therefore provides the basis for theoretical and practical assessments of the effect of shield friction for the planning and construction phase of a tunnel. This becomes increasingly important in the light of new contractual developments that aim at differentiating “standard” from “special” advance in an objective and reproducible way.
A new A-type granitoid occurrence in southernmost Fennoscandia: geochemistry, age and origin of rapakivi-type quartz monzonite from the Pietkowo IG1 borehole, NE Poland
Authors: Grabarczyk Anna , Wiszniewska Janina , Krzemińska Ewa , Petecki Zdzisław
Published: January 2023

Rapakivi-type quartz monzonite and the underlying dark-grey granodiorite from the Pietkowo IG1 borehole, in the Polish part of southernmost Fennoscandia have been investigated using whole-rock geochemistry, Sm–Nd isotope geochemistry and U–Pb zircon dating. The quartz monzonite was emplaced at 1495–1491 Ma, although slightly older zircon cores (antecrysts) of 1513 Ma imply a two-stage crystallization. The geochemical similarities with Mazury Complex granitoids, their metaluminous and alkali-calcic nature, elevated contents of F, Ga and high-field-strength-elements (HFSE), indicate that the Pietkowo IG1 rapakivi-type quartz monzonite is an ‘A-type’ granitoid. The presence of magnetite and titanite indicates crystallization under oxidizing conditions. The rock is classified as A2 sub-type, and the Nb/Y ratio implies a within-plate setting. The dark-grey granodiorite, dated to 1813 Ma, has a calc-alkaline character, typical of a volcanic-arc environment. Initial whole rock εNd values range between -2.9 and -3.3 for the rapakivi-type quartz monzonite and from -1.0 to + 1.1 for the dark-grey granodiorite. We suggest that the A-type Pietkowo IG1 rapakivi-type quartz monzonite was generated from the dark-grey granodiorite via partial melting at middle to lower crustal levels. The most plausible ascent route for the quartz monzonite was via lithospheric-scale weakness zones, between the eastern margin of the Mazowsze Domain and Belarus-Podlasie Granulite Belt, i.e., the Białystok fault. Therefore, the Pietkowo IG1 rapakivi-type quartz monzonite is a representative of the Mesoproterozoic A-type granitoid occurrence in southernmost Fennoscandia.
Exposure to psychotropic drugs before and during pregnancy: what has changed over the last two decades?
Authors: Robiyanto Robiyanto , Schuiling-Veninga Catharina C M , Bos Jens H J , Hak Eelko , van Puijenbroek Eugène P
Published: January 2023

Trends in prescribing psychotropic drugs before and during pregnancy may have changed over the years, but actual information is lacking. We therefore compared and assessed the exposure and acceptance rates of classes of antipsychotic (+ lithium), anxiolytic, sedative/hypnotic, antidepressant, and psychostimulant before and during pregnancy in the past two decades. All singleton pregnancies with ≥1 prescription of psychotropic drug from six months before pregnancy until child’s birthdate were identified in the pregnancy subset of the IADB.nl prescription database. The prescription patterns of psychotropics were distinguished as continuation rate (CR), initiation rate (IR), discontinuation rate (DR), total exposure rate (TER), and acceptance rate. Singleton pregnancies exposed to psychotropic drugs before and during pregnancy increased from 118.4 to 136.5 (per 1000 singleton pregnancies) between decades. Changing trends were observed in decade 2, including a high increase in the TER of antipsychotic class (3.3 to 6.8) and antidepressant class (23.0 to 40.6). A marked increase for individual drugs was seen for sertraline (TER: 0.6 to 6.6 and PAT: 35.3% to 82.5%), citalopram (TER: 2.3 to 10.0 and PAT: 51.1% to 74.6%), and quetiapine (TER: 0.4 to 3.1 and PAT: 57.1% to 66.0%). Although the total exposure rates of five classes of psychotropics in singleton pregnancies increased in decade 2, only antidepressant class had a higher acceptance rate during pregnancy. Certain SSRI antidepressants and atypical antipsychotics were more frequently prescribed in decade 2 than in decade 1, reflecting that treatment options were preferred for safer treatment choices.
A single-center, open-label trial on convenience and complications of rechargeable implantable pulse generators for spinal cord stimulation: The Recharge Pain Trial
Authors: Hajiabadi Mohammad Mehdi , Vicheva Petya , Unterberg Andreas , Ahmadi Rezvan , Jakobs Martin
Published: January 2023

Rechargeable implantable pulse generators (r-IPGs) have been available for spinal cord stimulation (SCS) claiming to offer a longer service life but demanding continuous monitoring and regular recharging by the patients. The aim of the study (DRKS00021281; Apr 7th, 2020) was to assess the convenience, safety, and acceptance of r-IPGs and their effect on patient lives under long-term therapy. Standardized questionnaires were sent to all chronic pain patients with a r-IPG at the time of trial. Primary endpoint was the overall convenience of the charging process on an ordinal scale from “very hard” (1 point) to “very easy” (5 points). Secondary endpoints were charge burden (min/week), rates of user confidence and complications (failed recharges, interruptions of therapy). Endpoints were analyzed for several subgroups. Data sets n = 40 (42% return rate) were eligible for analysis. Patient age was 57.2 ± 12.6 (mean ± standard deviation) years with the r-IPG being implanted for 52.1 ± 32.6 months. The overall convenience of recharging was evaluated as “easy” (4 points). The charge burden was 112.7 ± 139 min/week. 92% of the patients felt confident recharging the neurostimulator. 37.5% of patients reported failed recharges. 28.9% of patients experienced unintended interruptions of stimulation. Subgroup analysis only showed a significant impact on overall convenience for different models of stimulators (p < 0.05). Overall, SCS patients feel confident handling a r-IPG at high rates of convenience and acceptable effort despite high rates of usage-related complications. Further technical improvements for r-IPGs are needed.
A PCA-AHC Approach to Provenance Studies of Non-Ferrous Metals with Combined Pb Isotope and Chemistry Data
Authors: Tomczyk Céline , Żabiński Grzegorz
Published: January 2023

This paper discusses the applicability of the Principal﻿ Component Analysis-Agglomerative Hierarchical Clustering (PCA-AHC) approach to provenance studies of non-ferrous metals using combined Pb isotope and chemistry data. Pb isotopic ratios were converted to the natural abundance of individual isotopes and then to weight units. Next, all relevant variables (Pb isotopes and trace elements) were processed with PCA and AHC to examine the relationships between observations. The method is first verified on three literature-based case studies (1, 2, and 3)﻿. It is argued that, as is the case in archaeological iron provenance studies, the PCA-AHC method is also viable for non-ferrous metals. This method can greatly facilitate research, compared to conventional biplots with ratios of Pb isotopes and trace elements. Additionally, PCA-AHC can become part of the initial deposit selection process, and it can help clarify less obvious classification cases. The main problem with a practical application of this approach is insufficient deposit datasets with complete Pb isotopic and chemistry data. In such cases, it is possible to use the PCA-AHC method separately on Pb isotopic and chemistry data and then to compare and contrast results. Alternatively, the proposed approach can be used solely with Pb isotopic data. This application is shown in two additional case studies (4 and 5), which demonstrate the method’s application for tracing artefacts to their parent ores using datasets with a few thousand observations.
Tree-size heterogeneity modulates the forest age-dependent carbon density in biomass and top soil stocks on Mediterranean woodlands
Authors: Hernández-Alonso Héctor , Madrigal-González Jaime , Tornos-Estupiña Lorién , Santiago-Rodríguez Alberto , Alonso-Rojo Pilar , Morera-Beita Albert , Silla Fernando
Published: January 2023

Aims

Carbon accumulation in terrestrial ecosystems is inherent to the vegetation development and ageing process. Primary productivity synthetize biomass which is constantly incorporated to soil. Vegetation community composition, and other ecological drivers, are known to mediate biomass production. However, links between forest developmental stage and ecological drivers of carbon stocks are unexplored. We address this topic under the prediction that species-rich and uneven-sized forests can improve carbon storage potential in biomass and topsoil fraction across its development.

Methods

The study was carried in forest stands growing under Mediterranean conditions in Central Spain. Carbon content in both above- and below-ground tree biomass and in topsoil organic matter (0–40 cm) was measured in 30 sampling plots of variable size (900–3000 m2). We also assessed Shannon species diversity index, Gini tree-size inequality index and forest developmental stage using dendrochronological procedures to derive the mean age of the oldest trees. First-order interaction terms between diversity factors and forest age were regressed against carbon density in compartment-independent regressions.

Results

Forest-age and tree-size heterogeneity coupling was the main factor driving carbon density of both compartments. The interaction showed that woodlands maximize density in aged forests composed by uneven-sized trees. Models gave not support to consider species diversity as a mediator of carbon stocks.

Conclusion

Our results shed light on how tree-size heterogeneity can regulate the temporal dimension of forest ageing to rise the carbon storage potential. Mature forests in semi-arid environments cannot store carbon due to their intrinsic ontogeny, they need to grow structurally diverse.
Life-LCA: case study of the life cycle impacts of an infant
Authors: Bossek David , Bach Vanessa , Finkbeiner Matthias
Published: January 2023

Purpose

The recently published first Life-LCA case study of a human being (0–49 years) did not use primary data for the “childhood and youth stage” (0–17 years). Consumption was assumed to contribute 50% of the calculated 48thbaseline year. This led to uncertainties as consumer behavior changes from birth to adulthood. Furthermore, transport emissions and environmental impacts before birth were neglected. Therefore, this paper analyzes the prenatal and infancy phase (0–3 years) to develop the Life-LCA method and database further and evaluate generic assumptions.

Methods

The Life-LCA method sets the reporting unit to newly defined prenatal and infancy phases. The reporting flow describes the range of all consumed products attributable to an infant. Primary data was collected with a sample of three study objects—a pregnant mother, a newborn baby, and a 3-year-old infant—living in Germany. The following environmental impact assessment categories are considered: climate change (GWP), acidification (AP), eutrophication (EP), and photochemical ozone creation (POCP).

Results and discussion

Prenatal and infancy phase burdens account for a GWP of 4,011 kg CO2-eq., an AP of 22.3 kg SO2-eq., an EP of 10.7 kg PO4-eq., and a POCP of 1.7 kg C2H4-eq. The share of the prenatal phase is around 15–20% for all impact categories. Transport is a hotspot for GWP (30–60%) and POCP (45–70%) in both phases. AP (50%) and EP (45–50%) are dominated by food products, mainly meat (45%) and dairy products (35%). For the prenatal phase, energy and water consumption at birth rank third in GWP (8%). Diapers account for 6% (GWP) of the environmental burden in the infancy phase. Assumptions made in the first Life-LCA study connect closely with the values calculated for the first three years of infancy. A remaining challenge is allocating the impacts between infants and parents and developing a methodology for assessing data quality.

Conclusion

Focusing on two new life phases has led to the subdivision of the “childhood and youth stage” and an extension of the system boundaries. The results' uncertainty was reduced by developing a new set of specific datasets focusing on several study objects. The case study results show the importance of primary data collection for evaluating generic assumptions. Additional studies on childhood and adolescence from 3 to 17 years are suggested for a robust assessment of the complete “childhood and youth stage.”
A Religion “Based Upon Principles, And Not Upon Persons”: The Heart of the “Strategic Fit” of Swami Vivekananda’s Promotion of Vedānta?
Authors: Beckerlegge Gwilym
Published: January 2023

Adapting the SWOT matrix used in the study of the effectiveness of organizations, this article employs the notion of “strategic fit” to examine reasons frequently put forward to explain the positive reception of Swami Vivekananda’s message by sympathizers during his visits to the United States and England. The article suggests that Vivekananda maximized the strategic fit of his message by addressing prominent Christian theological concerns of the day, which would have impinged on many in his circle who retained their Christian identity. It is argued that, by recasting these concerns within the framework of his understanding of Vedānta, Vivekananda loosened, if not completely untied, the theological moorings of the religious way of thinking of his audience, as exemplified by his invitation that each person should accept Ramakrishna “in your own light” and his emphasis on the “most intensely impersonal” nature of the religion he offered. The article concludes that Vivekananda’s insistence on the “impersonal nature” of the religion he promoted, and the fluid interface between Hindu arguments and his idea of a universal religion, arguably left contentious questions for later generations of devotees to resolve.
Thoracic aortic aneurysm and atrial fibrillation: clinical associations with the risk of stroke from a global federated health network analysis
Authors: Proietti Riccardo , Rivera-Caravaca José Miguel , Harrison Stephanie Lucy , Buckley Benjamin James Roy , López-Gálvez Raquel , Marín Francisco , Fairbairn Timothy , Madine Jillian , Akhtar Riaz , Underhill Paula , Field Mark , Lip Gregory Yoke Hong
Published: January 2023

Background

An association with aortic aneurysm has been reported among patients with atrial fibrillation (AF). The aims of this study were to investigate the prevalence of thoracic aorta aneurysm (TAA) among patients with AF and to assess whether the co-presence of TAA is associated with a higher risk of adverse clinical outcomes.

Methods and results

Using TriNetX, a global federated health research network of anonymised electronic medical records, all adult patients with AF, were categorised into two groups based on the presence of AF and TAA or AF alone. Between 1 January 2017 and 1 January 2019, 874,212 people aged ≥ 18 years with AF were identified. Of these 17,806 (2.04%) had a TAA. After propensity score matching (PSM), 17,805 patients were included in each of the two cohorts. During the 3 years of follow-up, 3079 (17.3%) AF patients with TAA and 2772 (15.6%) patients with AF alone, developed an ischemic stroke or transient ischemic attack (TIA). The risk of ischemic stroke/TIA was significantly higher in patients with AF and TAA (HR 1.09, 95% CI 1.04–1.15; log-rank p value < 0.001)

The risk of major bleeding was higher in patients with AF and TAA (OR 1.07, 95% CI 1.01–1.14), but not significant in time-dependent analysis (HR 1.04, 95% CI 0.98–1.10; log-rank p value = 0.187),

Conclusion

This retrospective analysis reports a clinical concomitance of the two medical conditions, and shows in a PSM analysis an increased risk of ischemic events in patients affected by TAA and AF compared to AF alone.
How attributions of coproduction motives shape customer relationships over time
Authors: Güntürkün Pascal , Haumann Till , Edinger-Schons Laura Marie , Wieseke Jan
Published: January 2023

Despite the proliferation of coproduction concepts in various B2C contexts, knowledge on how coproduction shapes customer relationships is still surprisingly limited, as prior studies find mixed results and are bound to a short-term perspective. The present study addresses these limitations by providing first insights into the underlying psychological processes that explain differences in the short- and long-term relationship consequences of positive and negative coproduction perceptions. Drawing from the multiple inference model, this research shows how customers’ ambivalent attributions of a firm’s coproduction motives (i.e., firm-serving and customer-serving) affect customer satisfaction, willingness to pay, and spending behavior over time. The results of a latent growth analysis based on a longitudinal field study (n1 = 12,662; six waves) show that coproduction can harm customer relationships in the long-run, as the detrimental effects of firm-serving motive attributions are temporally more persistent than the favorable but ephemeral effects of customer-serving motive attributions. An additional experiment (n2 = 931) and field study (n3 = 360) confirm the generalizability of the key findings and provide new managerial insights into how firm-specific characteristics of a coproduction concept (i.e., coproduction intensity, design freedom, monetary savings) influence customer attributions different coproduction motives and thereby shape customer relationships over time.
Copula modelling with penalized complexity priors: the bivariate case
Authors: Battagliese Diego , Grazian Clara , Liseo Brunero , Villa Cristiano
Published: January 2023

We explore the use of penalized complexity (PC) priors for assessing the dependence structure in a multivariate distribution F, with a particular emphasis on the bivariate case. We use the copula representation of F and derive the PC prior for the parameter governing the copula. We show that any $$\alpha $$
α
-divergence between a multivariate distribution and its counterpart with independent components does not depend on the marginal distribution of the components. This implies that the PC prior for the parameters of the copula can be elicited independently of the specific form of the marginal distributions. This represents a useful simplification in the model building step and may offer a new perspective in the field of objective Bayesian methodology. We also consider strategies for minimizing the role of subjective inputs in the prior elicitation step. Finally, we explore the use of PC priors in Bayesian hypothesis testing. Our prior is compared with competing default priors both for estimation purposes and testing.
Recent Developments in Fatigue Assessment of Ships and Offshore Structures
Authors: Dong Yan , Garbatov Y. , Soares C. Guedes
Published: January 2023

A review is provided of various approaches that have been adopted recently to assess the fatigue of ships and offshore structures. The relevant fatigue loading is reviewed first, focusing on the successive loading and unloading of the cargo and the transient loadings. The factors influencing fatigue strength are discussed, including the geometrical parameters, material, residual stress, and ones related to the environment. Different approaches for fatigue analyses of seam-welded joints are covered, i.e., the structural stress or strain approach, the notch stress or strain approach, notch intensity approach, and the crack propagation approach.
Religious Freedom and LGBTIQA + Students
Authors: Jones Tiffany
Published: January 2023

Introduction

The United Nations called member states to better support the education rights of lesbian, gay, bisexual, transgender, intersex, queer and asexual (LGBTIQA +) people in recent years. However, Australian policy debates about schools’ ‘religious freedom’ and exemptions around gender and sexuality discrimination continue.

Methods

This article explores 1293 LGBTIQA + students’ experiences around religious freedom, gender, and sexuality by school type using data from the 2022 ‘Gender and Sexuality Expression in Schools’ survey. To understand correlations for students’ religious vs. non-religious educational institution types, basic descriptive and correlative statistical analyses were undertaken for quantitative data in SPSS and Excel including chi-square tests, alongside Leximancer-supported thematic analyses of qualitative responses.

Results

Attending religious schools was associated with (1) increased anti-LGBTIQA + and religious freedom-restricting policies, messages, and practices; (2) increased sexual orientation and gender identity and expression change efforts (SOGIECE) messages and practices; and (3) increased negative consequences and feelings. In religious education sites, professionals — especially teachers/educators — were more likely to spread anti-LGBTIQA + messaging at class/group and school-wide levels especially around ‘sinning’; however, professional codes appeared deterrents for school psychologists. In government schools, students more often unofficially spread anti-LGBTIQA + messaging around ‘brokenness’ or ‘social harmfulness’, mostly one-on-one.

Conclusions

The article shows the value of anti-discrimination laws and professional codes in reducing official problematic practices, for those contexts and professionals they applied to.

Policy Implications

Removal of exemptions for religious education institutions in anti-discrimination laws, revisions of education policies, and clearer protections for LGBTIQA + people in educators’ professional codes are recommended.
Application of nickel-doped graphene nanotubes to modified GCE as a sensitive electrochemical sensor for the antipsychotic drug clozapine in spiked human blood serum samples
Authors: Ghanbari Mohammad Hossein , Norouzi Zahra , Amiri Anahid
Published: January 2023

Clozapine (CLZ) is one of the most vital medications for managing schizophrenia, and the timely measurement of CLZ levels has been recognized as an obstacle to the wider use of CLZ. Herein, for the first time, nickel-doped graphene nanotubes (Ni@GRNT) were used to construct an electrochemical CLZ sensor by drop coating Ni@GRNT suspension on a glassy carbon electrode. The Ni@GRNT was synthesized and characterized using X‐ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. The electrochemical behavior and influence of different physicochemical factors of sensing electrodes were investigated by using cyclic voltammetry, EIS technique, and differential pulse voltammetry techniques. Also, the catalytic rate constant (kcat) and the transfer coefficient (α) were calculated. The modified electrode illustrated satisfactory linear range, detection limit (LOD), reusability, and reproducibility results. At optimal experimental conditions, measurements can be performed at a broad linear dynamic range of 0.3 nmol L−1–60.0 μmol L−1CLZ and with a LOD of 0.1 nmol L−1. The sensitivity value was estimated to be 3.06 μA µmol L−1 cm−2. Ultimately, this platform was successfully used for CLZ sensing in spiked human blood serum and tablet samples with an accuracy of > 93%.

Graphical abstract
Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders
Authors: Turek Justyna , Gąsior Łukasz
Published: January 2023

Women are significantly more likely to develop depression than men. Fluctuations in the ovarian estrogen hormone levels are closely linked with women's well-being. This narrative review discusses the available knowledge on the role of estrogen in modulating brain function and the correlation between changes in estrogen levels and the development of depression. Equally discussed are the possible mechanisms underlying these effects, including the role of estrogen in modulating brain-derived neurotrophic factor activity, serotonin neurotransmission, as well as the induction of inflammatory response and changes in metabolic activity, are discussed.
Thermodynamic and kinetic considerations of nitrogen carriers for chemical looping ammonia synthesis
Authors: Gao Wenbo , Wang Runze , Feng Sheng , Wang Yawei , Sun Zhaolong , Guo Jianping , Chen Ping
Published: January 2023

Ammonia (NH3) is a promising clean energy carrier, provided that its production is driven by renewable energy rather than fossil fuel-based Haber–Bosch (H–B) process. Chemical looping ammonia synthesis (denoted as CLAS) can intervene in the ubiquitous scaling relations in catalytic ammonia synthesis by separately feeding reactants to a nitrogen carrier to achieve atmospheric operation, which provides an alternative synthetic route to the H-B process. The key of CLAS is to develop efficient N carrier materials with suitable thermodynamic and kinetic properties. Metal nitrides and metal imides are two kinds of N carrier materials for the CLAS process, and H2 and H2O are commonly used as the hydrogen sources of NH3. Here, we first analyze the thermodynamic properties of the reactions of various metal nitrides and imides with water or hydrogen to produce NH3, N2 fixation on metals or metal hydrides, and the regeneration of metals from metal oxides, respectively. The thermodynamic calculation results display the reduction of main group metal hydroxide, early transition metal oxides, and rare earth metal oxides to the corresponding metallic state or hydrides, the nitridation of late transition metals to the corresponding nitrides, are the thermodynamic limiting steps for the metal nitride carriers. The metal imides, such as lithium imide and barium imide, have the relatively proper thermodynamics for two-step chemical looping reactions, however, their performance is limited by the thermodynamics of hydrogenation reaction. Moreover, for the thermodynamically unfavorable steps in the CLAS, we propose potential electrochemical processes to run the loop, such as molten salt electrolytic cell and solid electrolyte electrolytic cell. Finally, we put forward some strategies, such as controllable synthesis of N carriers and adding efficient catalysts, to improve the kinetics of chemical looping reactions.
Monotheism in Christian Liturgy
Authors: Geldhof Joris
Published: January 2023

In line with a profound theological understanding of liturgy as the Church at prayer (ecclesia orans), the focus of this Element is the variegated ways in which Christians address, turn to, and worship God in their central rituals and celebrations. Surveying a representative sample of official liturgical sources from different Christian Churches, the question is asked how 'pure' the monotheism expressed in them is. For one could argue that there is some ambiguity involved, especially with respect to (i) the peculiar position of Christ, the Son of God, and God the Father in liturgical prayers, and (ii) regarding the veneration of the saints. The essential key to unlock this complex and multi-layered reality is a meticulous study of the essential doxological nature of Christian liturgy, both from a phenomenological point of view and on the basis of fine textual analyses.
The Emergence of Geoengineering
Authors: Möller Ina
Published: January 2023

For many years, suggestions to 'geoengineer' the climate occupied a marginal role in climate change science and politics. Today, visions of massive carbon drawdown and sunlight reflection have become reasonable additions to conventional mitigation and adaptation. Why did researchers start engaging with ideas that were, for a long time, considered highly controversial? And how did some of these ideas come to be perceived worthy of research funding and in need of international governance? This Element provides an analysis of the recent history and evolution of geoengineering as a governance object. It explains how geoengineering evolved from a thought shared by a small network into a governance object that is likely to shape the future of climate politics. In the process, it generates a theory on the earliest phase of the policy cycle and sheds light on the question why we govern the things we govern in the first place.
Erasmus Darwin's Gardens
Authors: Elliott Paul A.
Published: January 2023

This first full study of Erasmus Darwin's gardening, horticulture and agriculture shows he was as keen a nature enthusiast as his grandson Charles, and demonstrates the ways in which his landscape experiences transformed his understanding of nature.