bluuebunny/crossref_metadata_2025 huggingface dataset:
Polymorphism of autoimmune encephalitis
Authors: Polonskii Evgeny L. , Skulyabin Dmitriy I. , Lapin Sergey V. , Krasakov Igor V. , Tikhomirova Olga V. , Nazarov Vladimir D. , Моshnikova Anna N. , Litvinenko Igor V. , Slashcheva Irina M. , Mamatova Natalia T. , Zakharova Natalia I. , Sokolova Natalia A. , Маzing Alexandra V. , Lyamina Alexandra V. , Belozerova Yulia B.
Published: January 2025

This review analyses the current understanding and diagnostic approaches to the management of patients with autoimmune encephalitis. Cellular and synaptic targets, involved in the pathological process in autoimmune encephalitis, are described. The presence of clinical and immunological differences in the pathology is emphasized: on the one hand, non-structural damage to the nervous system is combined with the subacute development of cognitive impairment, epileptic and psychopathological syndromes, which, on the other hand, are associated with polymorphic immunological heterogeneity. The algorithm for clinical and laboratory diagnosis is described, based on our own clinical observations of three patients. The first patient was diagnosed with a cross-autoimmune syndrome with a combination of Hodgkins lymphoma and anti-NMDA encephalitis, probably triggered by the reactivation of the EpsteinBarr virus with a fatal outcome. The second patient was diagnosed with autoimmune anti-LGI1 limbic encephalitis, and the third patient was seronegative to the available immunological antigens. The authors note the need to rethink the concept of encephalitis of unknown aetiology and its transformation into autoimmune encephalitis with the immunological diagnosis of three antigens (NMDA, LGI1, CASPR2). Considering the rarity of the disease, the high probability of initial admission to an infectious diseases or psychiatric hospital, it is worthwhile to explore this problem more widely at various research forums and to create a comprehensive, interdisciplinary approach to the diagnosis of this disease in the Russian Federation.
The translational potential of experimental pharmacology for cerebrovascular disorders
Authors: Mirzoian Ruben S. , Gan’shina Tamara S. , Kim Galina A. , Kurza Elena V. , Maslennikov Denis V. , Kurdyumov Il'ya N. , Turilova Antonina I. , Gorbunov Aleksander A.
Published: January 2025

The efficacy of reperfusion therapy to restore cerebral blood supply in patients with ischaemic cerebrovascular disorders is well recognized. Medications with proven cerebrovascular activity, such as oxymethylethylpyridine succinate (Mexidol), nicotinoyl-gamma-aminobutyric acid (Picamilon), and nimodipine, are successfully used in neurological practice with the first two having antiplatelet activity. This review analyses the vascular and antiplatelet effects of those medications, their effect on cerebral blood circulation, blood pressure and the central nervous system, and their neuroprotective activity. Potential compounds are also reviewed: S-amlodipine nicotinate and succinic acid ester of 5-hydroxyadamantan-2-one, which have significant cerebrovascular anti-ischaemic activity but a diametrically opposite effect on blood pressure. S-amlodipine nicotinate lowers blood pressure, while the succinic acid ester of 5-hydroxyadamantan-2-one elevates it. A GABA-positive component is present in the mechanism of action of all the studied drugs except for nimodipine. Experimental data on the effect of substances on cerebral circulation, blood pressure and platelet aggregation, as well as the interaction with GABAA receptors, significantly increase the translational potential of cerebrovascular medications.
Two clinical cases of glutaric aciduria type I in the Republic of Bashkortostan
Authors: Saifullina Elena V. , Magzhanov Rim V. , Davletova Anzhelika I. , Mardanova Al’bina K. , Timofeyeva Ekaterina A. , Kurkina Marina V. , Zakharova Ekaterina Yu.
Published: January 2025

Glutaric aciduria type I is an autosomal recessive disease caused by mutations in the GCDH gene, which encodes the glutaryl-CoA-dehydrogenase enzyme. A lack of this enzyme leads to the accumulation of glutaric and 3-OH-glutaric (3-hydroxyglutaric) acids in biological fluids and tissues, which have a neurotoxic effect primarily on subcortical brain structures. We present two clinical cases of glutaric aciduria type I in children diagnosed after developing neurological symptoms. One patient had acute disease onset in the form of an encephalopathic crisis, which is typical for most clinical cases of the disease. The other patient developed subacute symptoms. Generalized dystonic hyperkinesia was a key sign of the disease in both patients. Information from the medical history and clinical presentation, together with the neuroimaging results, enabled us to suspect the right diagnosis and to confirm it using biochemical and then molecular genetic tests. In both cases, despite diet therapy using a specialized medicinal product, the patients continued to have motor disturbances.
Gene Expression of Lysosomal Membrane Proteins in Parkinson Disease, Associated with Mutations in the Glucocerebrosidase Gene (GBA)
Authors: Usenko Tatiana S. , Bezrukova Anastasia I. , Bogdanova Darya A. , Nikolaev Mikhail A. , Miliukhina Irina V. , Gracheva Elizaveta V. , Senkevich Konstantin A. , Zakharova Ekaterina Yu. , Emelyanov Anton K. , Pchelina Sofya N.
Published: January 2025

Introduction. In carriers of a mutation in the lysosomal enzyme glucocerebrosidase (GBA) gene, the risk of Parkinson disease (PD) is increased by 78 times. However, not all carriers of the GBA gene mutations develop PD during their lifetime. We hypothesize that the dysfunction in the lysosomal membrane proteins involved in autophagy and transport of GBA into the lysosomes can contribute to the development of PD in carriers of mutations in the GBA gene.
The aim of the study was to assess the contribution of LAMP2 and SCARB2 genes expression in CD45+ peripheral blood cells to the development of GBA-PD.
Materials and methods. We examined 9 patients with GBA-PD, 9 asymptomatic GBA gene mutations carriers, 37 patients with PD, and 56 people in the control group. The relative mRNA level of LAMP2 and SCARB2 genes in CD45+ blood cells, obtained using magnetic sorting, was measured by quantitative real-time polymerase chain reaction using fluorescent probes.
Results. The relative mRNA level of LAMP2 and SCARB2 genes in CD45+ blood cells was reduced in patients with GBA-PD in comparison to patients with PD and to controls (LAMP2: p0.0001, p = 0.01 respectively; SCARB2: p = 0.01, p0.05, respectively) and in asymptomatic carriers of GBA gene mutations compared to patients with PD (LAMP2: p = 0.021; SCARB2: p0.05) and controls (LAMP2: p = 0.029). We also found decreased mRNA levels of the LAMP2 gene (p = 0.024) and the absence of differences in the mRNA levels of the SCARB2 gene (р0.05) in CD45+ blood cells in patients with GBA-PD when compared to the group of asymptomatic carriers of GBA gene mutations.
Conclusion. GBA-PD is characterized by a pronounced expression of the LAMP2 gene in the CD45+ peripheral blood cells, which may indicate a role of the decreased LAMP2 gene expression in the pathogenesis of GBA-PD.
Progressive ischaemic stroke: the difficulty in choosing antithrombotic therapy
Authors: Shirokov Evgenii A. , Lomakin Nikita V. , Buryachkovskaya Luydmila I.
Published: January 2025

Progressive ischaemic stroke is a clinical form of unfavourable progression of an acute cerebrovascular accident, found in around 20% of cases during the acute period. The strategy and approach to managing patients with an apparent deterioration during the acute period of stroke have not been fully established. Various types of antithrombotic therapy are discussed in the literature, with the use of antiplatelet drugs considered the most promising.
The authors analyse all types of antithrombotic therapy for progressive ischaemic stroke and examine in detail the only known case of late thrombolysis, which was performed in 1968.
Expanding the horizons of antiplatelet therapy. A pilot study of the antiplatelet properties of a new tropane alkaloid
Authors: Mirzoian Ruben S. , Shabalina Alla A. , Gan’shina Tamara S. , Kurdyumov Il'ya N. , Turilova Antonina I. , Kostochka Leonid M. , Kozlov Anton V. , Annushkin Vladislav A. , Kornilova Anastasia A. , Tanashyan Marine M.
Published: January 2025

Introduction.The article discusses the search for new and highly effective drugs for the prevention and treatment of cerebrovascular disease. Theaimwas to examine the effect of the acyl hydrazone tropane derivative on individual platelet aggregation (PA) sensitivity in in vitro studies.
Results. We present the results of a pilot study on the effect of a new acyl hydrazone tropane derivative acyl hydrazone (2,3,4-trimethoxy-N'-(8-methyl-8-azabicyclo [3.2.1.] octane-3-ylidene) benzohydrazide hydrochloride on PA properties in vitro in healthy volunteers and in patients with chronic cerebrovascular disease.
Conclusion. The studied compound has a pronounced ability to suppress PA when administered intravenously in vivo in two concentrations, equivalent to doses of 10 and 100 mg/kg, and its effect is superior to the comparator acetylsalicylic acid, which is used in clinical practice as an antiplatelet drug.
A clinical case of fatal familial insomnia with a transient positive response to corticosteroids
Authors: Shpilyukova Yulia A. , Seliverstov Yury A. , Nuzhny Evgeniy P.
Published: January 2025

Fatal familial insomnia (FFI) is a rare genetic human prion disease with an autosomal dominant pattern of inheritance caused by a D178N mutation in the PRNP gene. FFI is characterized by a variable clinical presentation and subacute manifestation. The latter prompts to consider autoimmune encephalitis as a differential diagnosis in the diagnostically challenging patients. Here, we present a clinical case of FFI that was initially misdiagnosed with autoimmune encephalitis. A 26-year-old woman presented with rapid development of diverse neurological features, autonomic and endocrine disturbances, which initially were considered as manifestations of an autoimmune disease due to the lack of clear indications of positive family history. She was started on corticosteroids with temporary stabilization and even with a mild improvement for several months. Progressive deterioration of her symptoms with development of the psychiatric and cognitive impairment, as well as subsequently received additional information regarding positive family history, prompted us to perform a PRNP gene test that revealed a D178N mutation and confirmed an FFI diagnosis.
Changes in the in-hospital mortality due to stroke and factors affecting its reduction in the European Union, Middle East, USA, Canada, Ethiopia and China
Authors: Vozniuk Igor A. , Morozova Elena M. , Prokhorova Maria V.
Published: January 2025

Introduction. While a specialized healthcare system is being developed for patients with stroke, early in-hospital mortality has been rightly chosen as a target indicator. It integrally reflects the correctness of organizational decisions, the completeness and quality of the diagnostic process, the availability of help, and factors relating to patient comorbidities.
Aim. To gather information reflecting the level of the in-hospital mortality due to stroke and factors leading to its reduction.
Materials and methods. PubMed was used to search the Medline database with the keywords mortality rate, in-hospital mortality, stroke, and prediction. The review included sources in any language from the year 2000 to the present if the full text was available online. Most of the statistical data were obtained from national stroke registries.
Results. Direct indicators of the percentage of in-hospital mortality varied significantly between different countries, precluding direct comparison. In-hospital mortality varied significantly and depended on clinical features and healthcare administration, including hospitals size and their level. A change in the in-hospital mortality was reported in 9 out of 22 reports and enabled us to track the degree of its reduction. The mean rate of reduction was 0.36% per year. Faster changes in this parameter were typical for ischaemic stroke and accompanied the implementation and expansion of cerebrovascular surgery centers with dedicated stroke units. We identified modifiable and non-modifiable factors that influence in-hospital mortality in stroke patients.
Conclusion. To more accurately evaluate the role of factors affecting in-hospital mortality in different countries, a meta-analysis is required, which would consider the regional organizational features, the availability of trained specialists at cerebrovascular surgery centers, and the degree of population awareness. The most consistent predictors of the in-hospital mortality were age, stroke type, stroke location, level of consciousness according to the Glasgow Coma Scale, stroke severity as measured by the NIHSS, and comorbidities. Factors that can reduce in-hospital mortality rates include population awareness, increased availability of ICU beds for stroke patients, telehealth, monitoring for late complications, and primary prevention.
The effect of education level on functional brain organization in patients with chronic cerebral ischemia
Authors: Fokin Vitaly F. , Ponomareva Natalia V. , Konovalov Rodion N. , Krotenkova Marina V. , Medvedev Roman B. , Lagoda Olga V. , Tanashyan Marine M.
Published: January 2025

The level of education is an important factor that prevents cognitive decline in normal and pathological aging, including in neurodegenerative and vascular diseases.
This study aimed to examine cerebral connectivity in patients with tertiary and secondary education suffering from chronic cerebral ischemia.
Materials and methods. We examined 54 patients (mean age 64.4 years) with chronic cerebrovascular disease who had completed either tertiary or secondary education. The Luria test was used to assess short-term memory, while the connectome organization was studied using resting-state functional magnetic resonance imaging.
Results. On average, patients with tertiary education recalled 35.0 1.1 words out of a possible 50, while patients with secondary education only recalled 31.1 1.2 words (p = 0.018). Patients with higher education had a higher number of interhemispheric connections in the connectome than the group without higher education. In patients without tertiary education, predominate the intrahemispheric connections in the right hemisphere. We hypothesize that this connectome organization provides a cognitive advantage in people with higher education, compared to patients without higher education.
Certain aspects of brain tumor angiogenesis
Authors: Frantsiyants Elena M. , Rostorguev Eduard E. , Sheiko Elena A.
Published: January 2025

Neuroepithelial tumors are one of the most common conditions with a high mortality rate. Despite the growing body of knowledge about the underlying biology of these tumors, their treatment has not changed significantly over the past decade.
Angiogenesis is a key component of the neoplastic process. Neoangiogenesis activity has a significant effect on tumor development and its metastatic potential. Studying how the growth and progression of gliomas are dependent on the degree of vascularisation has allowed the development of a new way of fighting tumors with antiangiogenesis therapy. Unfortunately, currently, antiangiogenesis therapy cannot cure a patient with glioma. The use of antiangiogenesis drugs to suppress tumor growth by inhibiting angiogenesis in gliomas is still limited despite being a promising direction. Information about molecular and genetic features of glial brain tumors, proangiogenic signalling pathways, mechanisms of angiogenesis, prognostic factors, etc., is essential to develop a new and effective therapy.
A recent literature review revealed quite contradictory data. On the one hand, neoangiogenesis of malignant brain tumors is considered to be an independent prognostic factor for glioma progression. However, some publications deny that angiogenesis in gliomas is a predictor of tumor development. All of the above underline the need for continued study into the relationship between angiogenesis and tumor growth.
Pathological fistula of the small intestine formed by magnetic foreign bodies
Authors:   MD, Professor of the Department of Pediatrics and Children's Surgery Medical Institute (MI) M.K. Ammosov Northeastern Federal University (NEFU), Deputy Director of Surgery Pediatric Center of RH No1  – M.E. Nikolaev National Centre of Medicine, chief freelance pediatric surgeon MH RS (Ya), Savvina V.A. , Sheikin I.Yu. ,   pediatric surgeon of the surgical department RH No1 – M.E. Nikolaev NCM, postgraduate student of the Department of Pediatrics and Children's Surgery MI M.K. Ammosov NEFU, assistant department, Tarasov A.Yu. ,   Head of the Surgical Department of the Pediatric center RH No1 – M.N. Nikolaev NCM, Nikolaev V.N. ,   Associate Professor of the Department of Pediatrics and Children's Surgery, Medical Institute, M.K. Ammosov NEFU, Varfolomeev A.R. ,   Doctor of Medical Sciences, Professor of the Department of Pediatrics and Children's surgery MI M.K. Ammosov NEFU
Published: January 2025

Magnetic foreign bodies of the gastrointestinal tract are not uncommon in children. A feature of the magnetic foreign bodies of the intestine is their tendency to stick together with each other with the development of intestinal perforation, intestinal fistulas or obstruction.
The purpose of this article is to show the development of a serious complication of magnetic foreign bodies in a child without clinical manifestations.
Foreign bodies of the gastrointestinal tract were discovered accidentally during an X-ray examination for another pathology. The duration of exposure to magnetic foreign bodies is unknown. The child's condition remained satisfactory. A fixed location of foreign bodies in the abdominal cavity was revealed, and the child underwent emergency and delayed surgery. The operation revealed a pathologically formed fistula between the lower horizontal branch of the duodenum and the initial section of the jejunum. The fistula was disconnected and the walls of the hollow organs were sutured. The patient was discharged with recovery.
Keywords: foreign bodies of the intestine, children, magnets
Управление устойчивым развитием промышленных отраслей в контексте обеспечения технологического обновления экономик регионов Российской Федерации
Authors: Полшков Ю.Н. , Ибрагимхалилова Д.В.
Published: January 2025

Работа посвящена проблемам продуктивности управления устойчивым развитием промышленных отраслей в условиях импортозамещения и обретения Россией технологического суверенитета. Расширен понятийно-категориальный аппарат посредством введения термина асимптотически экспоненциальной устойчивости развития промышленной отрасли. Выдвинута и подтверждена гипотеза о необходимости формирования территориальной образовательно-научно-технической среды, играющей роль ведущего фактора в обеспечении технологического обновления экономик регионов Российской Федерации. Усовершенствован научно-методический подход к прогнозированию временных интервалов устойчивого развития промышленных отраслей, основанный на вероятностно-статистическом и эконометрическом инструментарии, что позволяет моделировать управляющие воздействия по образу колеблемых динамических систем. Критически осмыслены государственные меры поддержки российской индустрии с позиций повышения продуктивности управления устойчивым развитием промышленных отраслей. Намечены направления дальнейших исследований по реализации технологического потенциала экономик регионов России.
Expanded ensemble predictions of toluene--water partition coefficients in the SAMPL9 LogP challenge
Authors: Goold Steven , Raddi Robert M. , Voelz Vincent
Published: January 2025

The logarithm of the partition coefficient (logP) between water and a nonpolar solvent is useful for characterizing a small molecule's hydrophobicity. For example, the water-octanol logP is often used as a predictor of a drug’s lipophilicity and/or membrane permeability, good indicators of its bioavailability. Existing computational predictors of water-octanol logP are generally very accurate due to the wealth of experimental measurements, but may be less so for other non-polar solvents such as toluene. In this work, we participate in a Statistical Assessment of the Modeling of Proteins and Ligands (SAMPL) logP challenge to examine the accuracy of a molecular simulation-based absolute free energy approach to predict water-toluene logP in a blind test for sixteen drug-like compounds with acid-base properties. Our simulation workflow used the OpenFF 2.0.0 force field, and an expanded ensemble (EE) method for free energy estimation, which enables efficient parallelization over multiple distributed computing clients for enhanced sampling. The EE method uses Wang-Landau flat-histogram sampling to estimate the free energy of decoupling in each solvent, and can be performed in a single simulation. Our protocol also includes a step to optimize the schedule of alchemical intermediates in each decoupling. The results show that our EE workflow is able to accurately predict free energies of transfer, achieving an RMSD of 2.26 kcal/mol (1.65 logP units), and $R^2$ of 0.80. An examination of outliers suggests that improved force field parameters could achieve better accuracy. Overall, our results suggest that expanded ensemble free energy calculations provide reasonably accurate logP prediction for a general-purpose force field.
QCxMS2 - a program for the calculation of electron ion- ization mass spectra via automated reaction network dis- covery
Authors: Gorges Johannes , Grimme Stefan
Published: January 2025

We present a new fully-automated computational workflow for the calculation of electron ionization mass spectra by automated reaction network discovery, transition state theory and Monte-Carlo simulations. Compared to its predecessor QCxMS [S. Grimme Angew. Chem. Int. Ed., 52, 6306-6312] based on extensive molecular dynamics (MD) simulations, QCxMS2’s more efficient approach of using stationary points on the potential energy surface (PES) enables the usage of accurate quantum chemical methods. Fragment geometries and reaction paths are optimized with fast semi-empirical quantum mechanical (SQM) methods and reaction barriers are refined at the density functional theory (DFT) level. This composite approach using GFN2-xTB geometries in combination with energies at the ωB97X-3c level proved to be an efficient combination. On a small but diverse test set of 16 organic and inorganic molecules, QCxMS2 spectra are more accurate than ones from QCxMS yielding on average a higher mass spectral matching of 0.700 compared to QCxMS with 0.622, and QCxMS2 is more robust with a minimal matching of 0.498 versus 0.100. Further improvements were observed when both geometries and energies were computed at the ωB97X-3c level, yielding an average matching score of 0.730 and a minimal score of 0.527. Due to its higher accuracy and robustness while maintaining computational efficiency, we propose QCxMS2 as a complementary, more reliable and systematically improvable successor to QCxMS for elucidating fragmentation pathways and predicting electron ionization mass spectra of unknown chemical substances, e.g., in analytical chemistry applications. If coupled to currently developed improved SQM methods, QCxMS2 opens an efficient route to accurate, and routine mass spectra predictions. The QCxMS2 program suite is freely available on GitHub.
Structure-Switching DNA Translators for the Integration of Transcription Factor-Driven CRISPR-Cas12a Activity into Synthetic Biomolecular Networks
Authors: Capelli Luca , Marzari Sofia , Spezzani Elena , Bertucci Alessandro
Published: January 2025

CRISPR-CAS systems have advanced many domains in life sciences, enabling diverse applications in gene editing, diagnostics, and biosensing. Here, we introduce a platform that leverages transcription factors (TFs) to regulate CRISPR-Cas12a trans-cleavage activity via engineered DNA translators. These dynamic DNA structures respond to TF binding by switching conformations, modulating Cas12a activity. Using TATA-binding protein (TBP) and Myc-Max as TF models, we optimized DNA translators for precise and tunable control with rapid response kinetics. We demonstrated the platform’s specificity and versatility by integrating TF-induced regulation into synthetic biology networks, including the activation of a fluorogenic RNA aptamer (Mango III) and the creation of an artificial multimolecular communication pathway between Cas12a and Cas13a. This work establishes TFs as effective regulators of CRISPR-Cas systems, enabling novel protein-nucleic acid communication channels, showing potential for novels synthetic biology applications.
Anisotropic lattice dynamics in a new helical InSeI polymorph: a crystal structure and polarized Raman spectroscopy study
Authors: Olano-Vegas Lucía , Spirito Davide , Modin Evgeny , Solokha Pavlo , Marras Sergio , Gobbi Marco , Casanova Fèlix , De Negri Serena , Hueso Luis E. , Martín-García Beatriz
Published: January 2025

Tetragonal InSeI is an interesting low-dimensional metal chalcohalide due to its composition and anisotropic crystal structure composed of helical chains, which give rise to optoelectronic properties with potential application in photodetectors, optical thermometers, and spintronic devices. However, experimental works lack on the study of its anisotropic or chiral behavior. Here we present the crystal structure of an unreported InSeI polymorph and study its lattice dynamics in bulk crystals and exfoliated nanowires by polarized Raman spectroscopy for two non-equivalent crystallographic planes. We determine the orientation of the helical chains and distinguish between crystallographic planes by linearly polarized measurements, evaluating the angle-dependent intensity of the modes, which allows assigning each mode to its representation. Circularly polarized Raman measurements do not reveal chiral phonons, despite the helical chains and anisotropic crystal structure. These results offer insight into the crystal structure of InSeI, which is fundamental for the fabrication of orientation-dependent optoelectronic and spintronic devices.
POSITIVE THINKING, RELATIONSHIP TO RESPECT TOWARD OTHERS AMONG KOYA UNIVERSITY TEACHERS
Authors: Shahen  , Saber Paiz
Published: January 2025

The aim of this study is to investigate the level of positive thinking and respect for others in general among teachers of Koya University, as well as reveal the level of each of these variables according to demographic variables (gender, faculty, academic degree). It also aims at finding a relationship between positive thinking and respect for others in the study sample. The research population consisted of 383 male and 136 female teachers. The sample was randomly selected from 100 male and female teachers. The study included measures of positive thinking and respect for others used, Statistical software (SPSS) was used to present and analyze the data. the most important statistical techniques used (mean, standard deviation, T test for two independent samples, Anova, Normal, and Pearson correlation) The results showed that Koya University teachers have high positive thinking above the average level, there is no statistically significant difference in their level of positive thinking according to the variables (gender, faculty, academic degree). The level of respect for others among teachers of Koya University is high and there is no statistically difference in the level of respect for others according to the variables (gender, faculty, academic degree). In light of the results, several recommendations were made.
In-silico, in-vitro antioxidant and anti-inflammatory potential of cynanchum callialatum leaves
Authors: K Nithyakalyani , B Gayathri , D Monisha , M Vignesh , K Balasundaram , V Jothi Ganesh , P Shanmugapandian
Published: January 2025

Inflammatory disorders, including various forms of rheumatic diseases, are a serious global issue. For the treatment of such disorders, the world's population is increasingly turning to herbal treatments. Many plants have been tested for anti-inflammatory and anti-arthritic properties, but only a handful have reached the therapeutic level. The purpose of this research is to determine the anti-inflammatory potential of Cynanchum callialatum leaves using in-silico and in-vitro investigations. The leaves' ethanol extract was produced and analysed for antioxidant capability using the DPPH and nitric oxide scavenging assays. Through molecular docking investigations, the phytoconstituents found in the leaves were docked against PLA2, COX-1, COX-2, and 5-LOX proteins. µAt 1000 µg/ml, the leaf extract had a maximum inhibitory percentage of 67.61 percent (nitric oxide) and 70.41 percent (DPPH), with an IC50 of 414.4 g/ml (nitric oxide) and 446.6 µg/ml (DPPH) (DPPH). The docking investigations indicated that the ligands inhibited the PLA2 protein via a mechanism and were submitted to a PLA2 inhibition experiment. The extract inhibited the enzyme by 71.92 percent at 1000 µg/ml, with an IC50 of 289.8 µg/ml. To assess the full inhibitory efficacy of PLA2, the phytoconstituents must be exposed to additional preclinical and clinical research.
A Experimentação Científica em atividades de Extensão na Universidade de Brasília com alunas do Ensino Médio
Authors: Queiroz Samyla Leite de , Bruno Ingryd Karine Batista , França Mônica Cristina , Meneses Rodrigo Arbey Munoz , Van Els Rudi Henri , Lopes Roseany de Vasconcelos Vieira
Published: January 2025

O presente artigo tem a finalidade de apresentar as atividades desenvolvidas dentro do projeto de extensão “Elas na Engenharia do Campus Gama”, que vem sendo desenvolvido no campus Gama (FGA) da Universidade de Brasília e que consiste em estimular alunas do Centro Educacional 8 (CED 08) do bairro do Gama a participar de atividades de iniciação científica e de extensão relacionadas aos cursos engenharia lá oferecidos: Automotiva, Aeroespacial, Energia, Eletrônica e Software e, com isso, espera-se despertar o interesse vocacional pela profissão de engenheira pelas mulheres, considerando que hoje elas representam menos do 20% dos alunos em cursos de engenharia na Universidade de Brasília-UnB.O desenvolvimento das atividades consistiu em ações de tutoria, reforço escolar, experimentação científica, além da inserção das alunas no ambiente universitário. O projeto de extensão vem sendo desenvolvido em ação continuadadesde 2021,sob a coordenação de duas equipes, uma delas é composta por uma professora e alunas extensionistas da FGA e a outra por uma professora e alunas da própria escola. As atividades desenvolvidas têm mostrado resultados importantes, pois além de melhorar o desempenho acadêmico na matéria de Química, algumas alunas além de expressarem o desejo de cursar engenharia ou outro curso da área das exatase ciência da computação estão inseridas nos referidos cursos na UnB ou em outras instituições.
Estímulo às Funções Executivas: Um relato de experiência na Educação Infantil
Authors: Rodrigues Claricy Araújo , Ferreira Bianca de Melo , Nobre Alena , Queiroz Jacqueline Travassos de
Published: January 2025

O presente artigo tem como objetivo analisar e discutir a importância da realização de brincadeiras para o desenvolvimento de crianças e também a sua relação com as funções executivas. O relato de experiência a seguir, é resultado de uma intervenção que foi realizada no ano de 2022 em uma escola infantil localizada na cidade de Garanhuns, em Pernambuco, com crianças na faixa etária de 4 a 6 anos. As brincadeiras foram retiradas do PIAFEX (Programa de Intervenção em Autorregulação e Funções Executivas) – dispõe de inúmeras atividades desenvolvidas com o propósito de auxiliar o desenvolvimento das funções executivas em crianças. Dentre os objetivos nas atividades escolhidas, é visto atividades que tem por função em crianças: estimular o controle inibitório e a flexibilidade cognitiva, aprimorar a memória e a atenção, adquirir a habilidade de pensar antes de agir, solucionar desafios inesperados e também orientar o comportamento de acordo com algumas regras para que o indivíduo consiga obter um bom desempenho em habilidades que serão bastante utilizadas em etapas futuras da vida. Com os resultados da prática, foi possível analisar que as crianças apresentavam uma energia comum para a idade e muita euforia em realizar o que era proposto quando estimuladas. No entanto, as atividades que precisavam categorizar e agrupar figuras, foram as que mais demonstraram problemas de compreensão. Para concluir, demonstra-se que a nossa visita na escola promoveu, ainda que em pequena escala, uma melhora no desempenho escolar e comportamental das crianças que foram alvo de nossa pesquisa.
Entrevista Ludmila Grego Maia: “A inserção da extensão nos currículos tem o potencial de renovar a educação”
Authors: Maia Ludmila Grego , Alves Guilherme
Published: January 2025

por Guilherme Alves
Jornalista do Decanato de Extensão (DEX/UnB) e Mestre em Ciência Política pelo Instituto de Ciência Política da Universidade de Brasília (Ipol/UnB).
A contribuição da extensão universitária na formação acadêmica através do Projeto EACINE com o documentário: “É Rio Ou Valão“
Authors: Bittencourt Suzana , Bezerra Márcia , Nakayama Luiza
Published: January 2025

O audiovisual é um instrumento de ensino-aprendizagem em Educação Ambiental (EA). Com o objetivo de avaliar a eficácia do documentário “É rio ou valão?” (7ª. Mostra Nacional de Produção Audiovisual Independente do Circuito Tela Verde Especial do Ministério do Meio Ambiente) no ensino-aprendizagem em EA, realizamos as atividades, em escolas da região metropolitana de Belém – PA, totalizando um público-alvo de 178 alunos do ensino fundamental. Dividimos, didaticamente, as atividades em três momentos: 1. Diálogo com os estudantes sobre o Projeto EACINE e distribuição de um questionário semiestruturado; 2. Exibição do documentário; 3. Roda de conversa, com distribuição do mesmo questionário. Ao analisarmos os questionários, podemos afirmar que houve relevante evolução nas reflexões e nos argumentos dos alunos, ao compararmos os momentos 1 e 3. Percebemos que, na roda de conversa, o desempenho dos alunos nas respostas faladas foi melhor do que nas escritas. Nas falas dos alunos, houve contribuições para o embasamento teórico de uma cidadania crítica, com quebras de paradigmas, além do desejo de desenvolver sugestões positivas e de realizar ações responsáveis, a fim de expandir horizontes e de solucionar os problemas da comunidade em que vivem. Portanto, o documentário despertou o interesse dos alunos, tendo em vista que o tema também é um problema presente na realidade belenense contribuindo, também, para construção de conceitos e para expressão de saberes de cidadania. Para os graduandos de Biologia da UFPA, participantes desse projeto, o documentário foi uma forma eficiente de não só aprender a ensinar, mas também de aprender a aprender, com os alunos do ensino fundamental.
Entrevista Simone Imperatore: “A extensão não é um acréscimo, mas sim parte integrante”
Authors: Imperatore Simone Loureiro Brum , Alves Guilherme
Published: January 2025

por Guilherme Alves
Jornalista do Decanato de Extensão (DEX/UnB) e Mestre em Ciência Política pelo Instituto de Ciência Política da Universidade de Brasília (Ipol/UnB).
Spatiotemporal Distribution Characteristics of Global Coarse-Mode Aerosol Optical Depth from 2012 to 2021
Authors: Piao Xingguang
Published: January 2025

Aerosols, as suspended solid and liquid particles in the atmosphere, play a significant role in global climate change and environmental quality. This study utilizes global coarse-mode aerosol optical depth (CAOD) data from 2012 to 2021, derived through a deep learning model, to comprehensively analyze the spatiotemporal distribution characteristics of coarse-mode aerosols. The findings reveal that global CAOD values exhibit a fluctuating downward trend during the study period, with a more pronounced decline in the Northern Hemisphere, likely due to regional variations in climate change, desertification, and human activities. Spatially, regions such as North Africa, the Middle East, and parts of Asia show higher CAOD values, associated with desert dust activity and anthropogenic emissions, whereas regions like South America, Australia, and Antarctica have lower CAOD values, attributed to their cleaner atmospheric conditions and minimal human activity. The complex CAOD variations in the mid-latitudes of the Northern Hemisphere are influenced by climatic conditions, topographical features, and the distribution of human activities. This study provides critical data for understanding the role of coarse-mode aerosols in global climate change and highlights the importance of considering geographical differences in aerosol distribution in climate change research. The study offers a scientific basis for formulating environmental policies and interventions. Future research will further explore the specific contributions of aerosol sources and their interaction mechanisms with climate change.
Public Policy and Advocacy in the Dietetics Curriculum: Challenges and Opportunities
Authors: Garay Jessica , Donnelly Meghan , Herman Amy , Lawson Kathryn , Martin Sarah , Reed Leah
Published: January 2025

Background: Registered Dietitian Nutritionists and other health professionals should be involved in advocacy efforts related to food access and health care. However, education about, and opportunities to actively participate in, public policy are often limited for dietetics students. The goal of this project was to identify how dietetics programs meet ACEND standards relating to public policy in their current and/or accredited program. Methods: An online survey was sent to dietetics faculty at U.S. higher education institutions. Survey questions focused on how programs currently meet ACEND standards for public policy or plan to meet standards in their dietetics program. Respondents were also asked to identify barriers, opportunities and resources related to implementing policy-related activities. Results: Of 54 total responses, 47 were partially or fully complete, representing 37 different institutions. Of these, 44% offer a dietetic internship, 38% offer a didactic program, and 13% offer a coordinated program. 40% of institutions have, or plan to start, a FEM program. Across all programs, writing a letter to a legislator and/or formal education about public policy were the most common strategies used to meet ACEND standards. Federal nutrition policies and professional dietetics issues were identified as the most important policy-related topics for students to learn about. Nearly all respondents were interested in adopting a pre-made curriculum designed to meet ACEND standards that included educational activities, sample assignments, and rubrics. Conclusion: Improvements are needed in the education and training provided to dietetics students in order to create an empowered dietetics profession that confidently advocates for policy improvements. The transition to the FEM presents an opportunity to develop hands-on educational activities related to public policy that can be implemented across the dietetics curriculum.
Student Perceptions of an Undergraduate Nutrition Peer Mentoring Program
Authors: Hudnall Sarah , Becker Rayanna , Meza Esparza Laura , Sanders Sara , Diker Ann
Published: January 2025

Background: Peer mentoring programs help students navigate challenges and stressors in their undergraduate education. There is minimal research on the effectiveness of these programs in nutrition and dietetics. Objective: The objective was to explore the perceptions of student mentors and mentees in an undergraduate nutrition peer mentoring program. Design: This qualitative research study utilized thematic analysis of student reflection papers. One hundred students were contacted via email to provide consent to review reflection papers. Reflection papers were collected from 33 students: 11 mentees and 22 mentors. Papers were imported into NVivo qualitative analysis software and coded for themes. Participants: Thirty-three undergraduate students enrolled in Careers in Nutrition and Dietetics (lower division course) and Nutrition Capstone (upper division course) during 2022 provided consent for reflection papers to be analyzed. Eleven students in the lower division course had been mentees, 22 in the upper division course had been mentors. Analysis: Reflection papers were imported into NVivo software. Each paper was randomly assigned to two researchers, reviewed, and coded for themes. Results: Three domains were identified—perceived benefits, perceived challenges, and suggestions. Perceived benefits included the themes relationships, advice, coping, and personal growth. Scheduling, incompatibility, and lack of confidence were themes within perceived challenges. Mentors suggested program improvement in structure and student compatibility. Conclusions and relevance: Findings suggest students valued participation in the peer mentoring program and would be interested in a longer mentoring experience.
Exploring Dietary Patterns with the Rapid Eating and Activity Assessment for Patients (REAP) Tool in a Dental School Clinic
Authors: Wiley Katherine , Zelig Rena , Samavat Hamed , Rigassio Radler Diane
Published: January 2025

Background: Dietary pattern assessment by healthcare providers leads to a better understanding of usual intake and evaluation of nutritional status, systemic health, and disease. Interprofessional team members can use such information to provide interventions leading to improved health outcomes. Objective: The aim was to explore the dietary patterns of adults seen in a dental clinic using the Rapid Eating and Activity Assessment for Patients (REAP) tool. Methods: This was a cross-sectional study of data from 220 adult patients (aged 18-89 years) who had a diet evaluation completed in a dental school clinic. Demographic information and REAP responses were obtained from the electronic health record and reported using frequency distributions. Results: The study sample (N=220) was 50.0% male (n= 110). The median (IQR) age and BMI were 56.0 years (IQR=48.2, 66.0) and 28.0 kg/m2 (IQR= 24.3, 32.8 kg/m2), respectively; 73.5% had a BMI considered overweight or obese. Approximately one-third reported usually/sometimes eating sweets more than twice/day (n=74, 35.9%) and drinking more than 16 ounces of SSBs (n=74, 34.1%). Most reported usually/sometimes eating less than 3 servings of whole grains (n=165, 75.0%), 2-3 servings of fruit (n=155, 71.1%), or 3-4 servings of vegetables (n=121, 70.8%) daily. Seventy-two percent (n=156) indicated they were willing to make dietary changes. Conclusion: This study revealed that the dietary patterns of adults seen in a dental school clinic did not align with the Dietary Guidelines for Americans recommendations. Diet assessment is feasible in this setting and may be an important part of interprofessional education.
Mubadalah and Sexual Consent Education: Bridging Religious Norms & Legal Perspective on Sexual Violence Prevention
Authors: Firdaus Slamet , Gumiandari Septi , Fitriana  , Nafi’a Ilman
Published: January 2025

Misconceptions surrounding sexual consent often serve as a catalyst for sexual violence. The absence of explicit refusal in a sexual encounter does not necessarily indicate agreement. The debate over sexual consent education has gained prominence, particularly in the context of Indonesia’s Draft Law on the Prevention and Handling of Sexual Violence (RUU PKS). This study critically examines polarized perspectives on this issue using a qualitative approach and the Mubādalah framework to find common ground. The findings reveal two opposing positions. The Institute for Criminal Justice Reform (ICJR) emphasizes that the absence of consent is a primary cause of sexual violence, advocating for sexual consent education as a preventive measure. In contrast, the Indonesian Family Love Alliance (AILA Indonesia) argues that such education contradicts Indonesia’s cultural and religious values, potentially fostering sexual permissiveness. AILA proposes a preventive approach rooted in local norms and values. The Mubādalah perspective provides a mediating lens, emphasizing that sexual activities outside marriage are impermissible in Islam. It reframes sexual consent within marital contexts and advocates education that prioritizes respect, mutual consent, and adherence to ethical and religious principles. This balanced approach addresses both ICJR’s and AILA’s concerns, fostering a culture of respect and responsibility while upholding religious values to prevent sexual violence.
Meningkatkan Profitabilitas pada Bank Umum Syariah melalui Rasio Keuangan
Authors: Defia Suci Adi Putri  , Rohmah Farida
Published: January 2025

Penelitian ini bertujuan untuk menganalisis pengaruh Capital Adequacy Ratio (CAR), Financing to Deposit Ratio (FDR), Non Performing Financing (NPF) dan Biaya Operasional Pendapatan Operasional (BOPO) terhadap Return On Asset (ROA) pada Bank Umum Syariah Indonesia periode 2018-2022. Penelitian ini merupakan penelitian kuantitatif. Jenis data yang digunakan yakni berupa laporan keuangan tahunan yang diperoleh dari website resmi masing-masing bank dari tahun 2018-2022. hasil penelitian menyatakan bahwa variable FDR dan NPF tidak berpengaruh signifikan terhadap variabel ROA. Variabel CAR menunjukan bahwa CAR memiliki arah yang positif dan memiliki pengaruh yang signifikan terhadap ROA. Sedangkan variabel BOPO berpengaruh negatif dan signifikan terhadap profitabilitas (ROA). Kemudian berdasarkan hasil uji secara simultan (uji f), keempat variabel tersebut yaitu CAR, FDR, NPF, dan BOPO secara bersamaan berpengaruh signifikan terhadap ROA.
The development of traditional cattle breeding in the Russian-Mongolian transborder area in the post-Socialist period (on the example of Buryatia and Mongolia)
Authors: Badaraev Damdin , Gombozhapov Alexandr
Published: January 2025

The article presents a general overview of the development of traditional cattle breeding in the Russian-Mongolian
transborder area in the post-socialist period. The authors note the symmetry of the processes on both sides of
the border, characterized by the revival of low-cost pasture livestock farming as a response to the challenges of the
transition period. Identical processes are observed between Mongolia and remote areas of Buryatia (Russia), where
there has been a return to the traditional pasture-based type of animal husbandry. The modern practice of nomadism
in Mongolia has a general tendency towards a lower degree of mobility and sedentariness. Semi-nomadic farming is
becoming an increasingly common form as a result of the adaptation of livestock farming to market conditions and the
environmental and climatic conditions of the arid zone of the Russian-Mongolian transborder.
Análisis de la literatura científica sobre aplicaciones móviles para la enseñanza de idiomas
Authors: Hernández Islas Mónica , Félix Aviña Vanessa Guadalupe , Rodríguez Melchor Vilma Zoraida
Published: January 2025

Las aplicaciones móviles para el aprendizaje de idiomas se han vuelto populares debido a su accesibilidad, flexibilidad y capacidad para brindar experiencias de aprendizaje personalizadas. Este artículo explora el desarrollo de aplicaciones móviles para el aprendizaje de idiomas a partir de las publicaciones más relevantes de la Web of Science en los últimos diez años. Se crearon mapas de concentración a través del programa VOSviewer para identificar países, instituciones, y conceptos más relevantes sobre el objeto de estudio. Los resultados muestran la relevancia de tecnologías emergentes como inteligencia artificial, analítica de datos y realidad aumentada para el diseño de modelos, sistemas y programas para el aprendizaje de idiomas.