bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy of Internet-Based Cognitive Behavioral Therapy for Depression and Anxiety among Global Population during the COVID-19 Pandemic: A Systematic Review and Meta-Analysis of a Randomized Controlled Trial Study
Authors: Komariah Maria , Amirah Shakira , Faisal Emir Gibraltar , Prayogo Stephanie Amabella , Maulana Sidik , Platini Hesti , Suryani Suryani , Yosep Iyus , Arifin Hidayat
Published: July 2022

Background: Depression and anxiety have become the most common mental health disorders worldwide during the COVID-19 pandemic, and increasing interest in telemedicine has led to the innovation of using internet-based cognitive behavioral therapy (iCBT). Objective: This systematic review and meta-analysis aimed to evaluate the efficacy of iCBT for depression and anxiety among the global population during the COVID-19 pandemic. Methods: A literature search was conducted on PubMed, Scopus, Cochrane, ProQuest, Wiley, and Web of Science using the PRISMA framework, and only randomized controlled trials (RCTs) were included in the study. A critical appraisal was also performed using Cochrane’s Risk of Bias (RoB) 2. The meta-analysis used random-effects models to analyze pooled mean difference (MD) and its p-value. Results: Twelve RCTs were included for qualitative analysis and nine RCTs, which yielded 6778 patients with depression and 6556 patients with anxiety during the COVID-19 pandemic, were included for quantitative analysis. Despite high heterogeneity, all studies had a low risk of bias. Pre- and post-iCBT intervention in the depression forest plot depicts a significant effect (p < 0.00001) with a pooled MD of 4.73 (95% CI: 4.55–4.90), while the pre- and post-iCBT intervention depicts a significant effect (p < 0.00001) with a pooled MD of 4.50 (95% CI: 4.34–4.67). This demonstrates that iCBT was found to significantly decrease depression and anxiety scores in patients during the COVID-19 pandemic. However, substantial heterogeneity was also found (I2 = 93%; p < 0.00001 and I2 = 90%) for the pre-/post-depression and anxiety forest plots, respectively. Conclusions: This meta-analysis comprises an evidence-based result for iCBT to treat depression and anxiety in the COVID-19 population, as indicated by the significantly lower assessment scores. Delivering iCBT in this situation needs to be considered more extensively, as it has promising results and yields the benefits of technological advancement in psychotherapy.
Variables Impacting the Quality of Care Provided by Professional Caregivers for People with Mental Illness: A Systematic Review
Authors: Bru-Luna Lluna M. , Martí-Vilar Manuel , Merino-Soto César , Salinas-Escudero Guillermo , Toledano-Toledano Filiberto
Published: July 2022

People with mental illness may need the support of caregivers in certain areas of their lives, and there is an increasing need for quality care for people with mental health problems by qualified health professionals. Often, these professionals may develop so-called burnout syndrome, although some authors point out that positive emotions may also arise. In addition, several variables can act as both protectors and stressors. Therefore, the main aim of the current study is to identify variables related to the professional care of people with mental illness (i.e., protective or stressor variables) through a systematic review. The review was conducted according to the PRISMA guidelines with a final selection of 20 articles found in the Web of Science, PubMed, ScienceDirect and Dialnet databases between the months of October and November 2019, and updated in June 2022. The results show that job satisfaction is a strong predictor of the quality of care, and that congruence between personal and organizational values is a very important factor. Meanwhile, working in the same job for successive years, working in community mental health teams and experiencing burnout act as stressors and reduce the quality of care provided.
Electrochemical Redox In-Situ Welding of Silver Nanowire Films with High Transparency and Conductivity
Authors: Zhang Wang , Bao Jiashuan , Xu Chenhui , Zhu Pengfeng , Pan Xiangliang , Li Rui
Published: July 2022

Silver nanowire (AgNW) networks with high transparency and conductivity are crucial to developing transparent conductive films (TCFs) for flexible optoelectronic devices. However, AgNW-based TCFs still suffer from the high contact resistance of AgNW junctions with both the in-plane and out-of-plane charge transport barrier. Herein, we report a rapid and green electrochemical redox strategy to in-situ weld AgNW networks for the enhanced conductivity and mechanical durability of TCFs with constant transparency. The welded TCFs show a marked decrease of the sheet resistance (reduced to 45.5% of initial values on average) with high transmittance of 97.02% at 550 nm (deducting the background of substrates). The electrochemical welding treatment enables the removal of the residual polyvinylpyrrolidone layer and the in-situ formation of Ag solder in the oxidation and reduction processes, respectively. Furthermore, local conductivity studies confirm the improvement of both the in-plane and the out-of-plane charge transport by conductive atomic force microscopy. This proposed electrochemical redox method provides new insights on the welding of AgNW-based TCFs with high transparency and low resistance for the development of next-generation flexible optoelectronic devices. Furthermore, such conductive films based on the interconnected AgNW networks can be acted as an ideal supporter to construct heterogeneous structures with other functional materials for wide applications in photocatalysis and electrocatalysis.
Reproductive Behaviour of 150-Gy-Treated Female Lobesia botrana (Lepidoptera: Tortricidae)
Authors: Saour George , Hashem Ali , Jassem Iyad
Published: July 2022

The sterile insect technique/inherited sterility (SIT/IS) has been suggested as an eco-friendly control tactic for area-wide integrated pest management approaches in order to control the European grapevine moth, Lobesia botrana. This study assessed the effects of an irradiation dose of 150 Gy administered to newly emerged female moths on their egg laying behaviour and mating ability at different ages at mating. Moreover, the effects of multiple mating on the mating ability of treated females, pattern of sperm precedence in twice-mated females and the flight response of treated and untreated males to treated and untreated calling females were also investigated. Females treated with 150 Gy initiated calling in a way similar to untreated females. When treated females were paired with untreated males, the mean number of eggs oviposited per female during 6 days was reduced (59.6 and 82.8 eggs/female, respectively), as was their mating ability and multiple mating compared with untreated females. The proportion of offspring fertilized by the second of the two males to mate with the female or last-male sperm precedence (P2 value) constituted 97% of the eggs, suggesting that the second male mate fathered the most offspring. The outcome of this work could be viewed as an integrated approach for improving effectiveness and enabling successful implementation of a SIT/IS program against L. botrana.
The Impact of Fast Radiation on the Phylogeny of Bactrocera Fruit Flies as Revealed by Multiple Evolutionary Models and Mutation Rate-Calibrated Clock
Authors: Valerio Federica , Zadra Nicola , Rota-Stabelli Omar , Ometto Lino
Published: July 2022

Several true fruit flies (Tephritidae) cause major damage to agriculture worldwide. Among them, species of the genus Bactrocera are extensively studied to understand the traits associated with their invasiveness and ecology. Comparative approaches based on a reliable phylogenetic framework are particularly effective, but several nodes of the Bactrocera phylogeny are still controversial, especially concerning the reciprocal affinities of the two major pests B. dorsalis and B. tryoni. Here, we analyzed a newly assembled genomic-scaled dataset using different models of evolution to infer a phylogenomic backbone of ten representative Bactrocera species and two outgroups. We further provide the first genome-scaled inference of their divergence by calibrating the clock using fossil records and the spontaneous mutation rate. The results reveal a closer relationship of B. dorsalis with B. latifrons than to B. tryoni, contrary to what was previously supported by mitochondrial-based phylogenies. By employing coalescent-aware and heterogeneous evolutionary models, we show that this incongruence likely derives from a hitherto undetected systematic error, exacerbated by incomplete lineage sorting and possibly hybridization. This agrees with our clock analysis, which supports a rapid and recent radiation of the clade to which B. dorsalis, B. latifrons and B. tryoni belong. These results provide a new picture of Bactrocera phylogeny that can serve as the basis for future comparative analyses.
Left Ventricular Noncompaction in Children: The Role of Genetics, Morphology, and Function for Outcome
Authors: Klaassen Sabine , Kühnisch Jirko , Schultze-Berndt Alina , Seidel Franziska
Published: July 2022

Left ventricular noncompaction (LVNC) is a ventricular wall anomaly morphologically characterized by numerous, excessively prominent trabeculations and deep intertrabecular recesses. Accumulating data now suggest that LVNC is a distinct phenotype but must not constitute a pathological phenotype. Some individuals fulfill the morphologic criteria of LVNC and are without clinical manifestations. Most importantly, morphologic criteria for LVNC are insufficient to diagnose patients with an associated cardiomyopathy (CMP). Genetic testing has become relevant to establish a diagnosis associated with CMP, congenital heart disease, neuromuscular disease, inborn error of metabolism, or syndromic disorder. Genetic factors play a more decisive role in children than in adults and severe courses of LVNC tend to occur in childhood. We reviewed the current literature and highlight the difficulties in establishing the correct diagnosis for children with LVNC. Novel insights show that the interplay of genetics, morphology, and function determine the outcome in pediatric LVNC.
Effectiveness and Safety of Apixaban in over 3.9 Million People with Atrial Fibrillation: A Systematic Review and Meta-Analysis
Authors: Buckley Benjamin J. R. , Lane Deirdre A. , Calvert Peter , Zhang Juqian , Gent David , Mullins C. Daniel , Dorian Paul , Kohsaka Shun , Hohnloser Stefan H. , Lip Gregory Y. H.
Published: July 2022

Background: There is a plethora of real-world data on the safety and effectiveness of direct-acting oral anticoagulants (DOACs); however, study heterogeneity has contributed to inconsistent findings. We compared the effectiveness and safety of apixaban with those of other direct-acting oral anticoagulants (DOACs) and vitamin K antagonists (VKA e.g., warfarin). Methods: A systematic review and meta-analysis was conducted retrieving data from PubMed, SCOPUS and Web of Science from January 2009 to December 2021. Studies that evaluated apixaban (intervention) prescribed for adults (aged 18 years or older) with AF for stroke prevention compared to other DOACs or VKAs were identified. Primary outcomes included stroke/systemic embolism (SE), all-cause mortality, and major bleeding. Secondary outcomes were intracranial haemorrhage (ICH) and ischaemic stroke. Randomised controlled trials and non-randomised trials were considered for inclusion. Results: In total, 67 studies were included, and 38 studies were meta-analysed. Participants taking apixaban had significantly lower stroke/SE compared to patients taking VKAs (relative risk (RR) 0.77, 95% confidence interval (CI) 0.64–0.93, I2 = 94%) and dabigatran (RR 0.84, 95% CI 0.74–0.95, I2 = 66%), but not to patients administered rivaroxaban. There was no statistical difference in mortality between apixaban and VKAs or apixaban and dabigatran. Compared to patients administered rivaroxaban, participants taking apixaban had lower mortality rates (RR 0.83, 95% CI 0.71–0.96, I2 = 96%). Apixaban was associated with a significantly lower risk of major bleeding compared to VKAs (RR 0.58, 95% CI 0.52–0.65, I2 = 90%), dabigatran (RR 0.79, 95% CI 0.70–0.88, I2 = 78%) and rivaroxaban (RR 0.61, 95% CI 0.53–0.70, I2 = 87%). Conclusions: Apixaban was associated with a better overall safety and effectiveness profile compared to VKAs and other DOACs.
Echocardiography Assessment of Cardiac Function in Adults Living with HIV: A Speckle Tracking Study in the Era of Antiretroviral Therapy
Authors: Mirea Oana , Manescu Mirela , Iordache Sorina , Marcu Andreea , Donoiu Ionut , Istratoaie Octavian , Dumitrescu Florentina , Militaru Constantin
Published: July 2022

Adults living with HIV (human immunodeficiency virus) infection (ALHIV) have high rates of cardiovascular events. New approaches are needed to detect subclinical cardiac dysfunction. We used conventional and speckle tracking echocardiography to investigate whether ALHIV display latent cardiac dysfunction. We analyzed 85 young subjects with HIV infection and free from cardiovascular risk factors (31 ± 4 years) and 80 matched healthy volunteers. We measured left ventricular (LV) layered global longitudinal strain, circumferential strain, peak longitudinal strain in the reservoir and contraction phases of the left atrium (LASr respectively LASct). In the HIV group, LV ejection fraction and s’ TDI (tissue doppler imaging) were slightly lower but still in the normal ranges. Layered longitudinal strain showed no significant difference, whereas circumferential global strain was significantly lower in the HIV group (−20.3 ± 3.9 vs. −22.3 ± 3.0, p < 0.001). LASr (34.3% ± 7.3% vs. 38.0% ± 6.9%, p < 0.001) was also lower in ALHIV and multivariate analysis showed that age (β = −0.737, p = 0.01) and infection duration (β = −0.221, p = 0.02) were independently associated with LASr. In the absence of cardiovascular risk factors, adults living with HIV display normal LV systolic function. Left atrial reservoir strain, is, however, decreased and suggests early diastolic dysfunction.
Influence of Sensor Position and Low-Frequency Modal Shape on the Sensitivity of Vibro-Acoustic Modulation for Impact Damage Detection in Composite Materials
Authors: Loi Gabriela , Aymerich Francesco , Porcu Maria Cristina
Published: July 2022

Very sensitive structural health monitoring methods are needed to detect barely visible impact damage in composite materials. Based on extracting non-linear modulated components from the frequency response of the damaged system, vibro-acoustic modulation (VAM) has shown to be effective in identifying the presence of damage at its early stage. A decisive role in the success of this technique is played by the choice of the high-frequency probe and the low-frequency pump sinusoidal signals that simultaneously excites the system. This study explores how the position of the sensing transducer, with respect to the modal shape of the pump excitation, may influence the sensitivity of the VAM technique for impact damage detection in composite laminates. This aspect has been scarcely investigated in previous research works, as other studies have focused more on the role of the probe frequency. Here, VAM tests were performed on a composite beam by using a frequency-swept pump vibration simultaneously with a high frequency probe excitation. The results of the experimental tests indicate that the VAM technique is capable of clearly revealing the presence of impact damage only when the sensor is placed on appropriate locations, which are directly related to the shape of the deformation activated by the applied excitation. These results suggest the adoption of low frequency excitations that activate multiple modal shapes to improve the effectiveness and reliability of VAM approaches.
Similarity Evaluation Rule and Motion Posture Optimization for a Manta Ray Robot
Authors: Cao Yonghui , Ma Shumin , Cao Yingzhuo , Pan Guang , Huang Qiaogao , Cao Yong
Published: July 2022

The current development of manta ray robots is usually based on functional bionics, and there is a lack of bionic research to enhance the similarity of motion posture. To better exploit the characteristics of bionic, a similarity evaluation rule is constructed herein by a Dynamic Time Warping (DTW) algorithm to guide the optimization of the control parameters of a manta ray robot. The Central Pattern Generator (CPG) network with time and space asymmetry oscillation characteristics is improved to generate coordinated motion control signals for the robot. To optimize similarity, the CPG network is optimized with the genetic algorithm and particle swarm optimization (GAPSO) to solve the problems of multiple parameters, high non-linearity, and uncertain parameter coupling in the CPG network. The experimental results indicate that the similarity between the forward motion pose of the optimized manta ray robot and the manta ray is improved to 88.53%.
Deep-Sea Underwater Cooperative Operation of Manned/Unmanned Submersible and Surface Vehicles for Different Application Scenarios
Authors: Yang Lei , Zhao Shengya , Wang Xiangxin , Shen Peng , Zhang Tongwei
Published: July 2022

In this paper, we propose three cooperative operational modes of manned and unmanned submersibles for a range of different deep-sea application scenarios. For large-scale exploration, a lander or an unmanned surface vehicle (USV) is paired with one or more autonomous underwater vehicles (AUVs), while the liberated research vessel R/V can transport the manned submersible to another area for diving operations. When manned submersibles and AUVs perform small-scale accurate measurements, the research vessel R/V supports both submersible types for diving operations and has a positioning and communication time allocation mechanism for cooperative operations. Through the analysis of the operating efficiency of different modes, we found that the cooperative operational mode based on the pure research vessel R/V is suitable for local small-scale accurate detection, and the cooperative operational mode based on the USV/lander system is suitable for large-scale and long-distance underwater operations.
Endophytic Fungi Associated with Coffee Leaves in China Exhibited In Vitro Antagonism against Fungal and Bacterial Pathogens
Authors: Lu Li , Karunarathna Samantha C. , Hyde Kevin D. , Suwannarach Nakarin , Elgorban Abdallah M. , Stephenson Steven L. , Al-Rejaie Salim , Jayawardena Ruvishika S. , Tibpromma Saowaluck
Published: July 2022

Coffee endophytes have been studied for almost 74 years, and several studies have demonstrated coffee-endophytic fungi with antibacterial and antifungal potential for human and plant pathogens. In this study, we isolated and identified a total of 235 strains of endophytic fungi from coffee leaf tissues collected in four coffee plantations in Pu’er city, Yunnan province, China. Molecular identification was carried out using maximum likelihood phylogenetic analysis of nuclear ribosomal internal transcribed spacer (ITS1-5.8S rDNA-ITS2) sequences, while the colonization rate and the isolation frequency were also calculated. Two pathogenic fungi (Alternaria alternata and Penicillium digitatum) and two pathogenic bacteria (Pseudomonas syringae and Salmonella enterica subsp. enterica) were used for screening the antagonistic activities of 61 strains of coffee-endophytic fungi by a dual-culture test assay while maximum likelihood phylogenetic analysis confirmed their natural classification. This is the first study of coffee-leaf-endophytic fungal diversity in China, and the results revealed that coffee-endophytic fungi from this study belong to the Ascomycota, distributed among two classes, 10 orders, and 17 families. Concurrently, endophytic fungi isolates distributed in Arthrinium, Biscogniauxia, Daldinia, Diaporthe, and Nigrospora showed strong antagonistic activities against the pathogens. For the pathogens Alternaria alternata and Pseudomonas syringae, Nigrospora XCE-7 showed the best inhibitory effects with inhibition rates of 71.76% and 61.11%, respectively. For the pathogen Penicillium digitatum, Daldinia ME-9 showed the best inhibitory effect with a 74.67% inhibition rate, while Biscogniauxia PTE-7 and Daldinia T5E-1-3 showed the best inhibitory effect with a rate of 60.42% against the pathogen Salmonella enterica subsp. enterica. Overall, our study shows the diversity of coffee endophytes in four coffee-growing areas in Pu’er city, Yunnan province, China, and their potential use as biological control agents against two fungal and two bacterial pathogens.
The Influence of Serious Extracranial Injury on In-Hospital Mortality in Children with Severe Traumatic Brain Injury
Authors: Chao Min , Wang Chia-Cheng , Chen Carl P. C. , Chung Chia-Ying , Ouyang Chun-Hsiang , Chen Chih-Chi
Published: July 2022

(1) Background: Severe traumatic brain injury (sTBI) is the leading cause of death in children. Serious extracranial injury (SEI) commonly coexists with sTBI after the high impact of trauma. Limited studies evaluate the influence of SEI on the prognosis of pediatric sTBI. We aimed to analyze SEI’s clinical characteristics and initial presentations and evaluate if SEI is predictive of higher in-hospital mortality in these sTBI children. (2) Methods: In this 11-year-observational cohort study, a total of 148 severe sTBI children were enrolled. We collected patients’ initial data in the emergency department, including gender, age, mechanism of injury, coexisting SEI, motor components of the Glasgow Coma Scale (mGCS) score, body temperature, blood pressure, blood glucose level, initial prothrombin time, and intracranial Rotterdam computed tomography (CT) score of the first brain CT scan, as potential mortality predictors. (3) Results: Compared to sTBI children without SEI, children with SEI were older and more presented with initial hypotension and hypothermia; the initial lab showed more prolonged prothrombin time and a higher in-hospital mortality rate. Multivariate analysis showed that motor components of mGCS, fixed pupil reaction, prolonged prothrombin time, and higher Rotterdam CT score were independent predictors of in-hospital mortality in sTBI children. SEI was not an independent predictor of mortality. (4) Conclusions: sTBI children with SEI had significantly higher in-hospital mortality than those without. SEI was not an independent predictor of mortality in our study. Brain injury intensity and its presentations, including lower mGCS, fixed pupil reaction, higher Rotterdam CT score, and severe injury-induced systemic response, presented as initial prolonged prothrombin time, were independent predictors of in-hospital mortality in these sTBI children.
Factors and Priorities Influencing Satisfaction with Care among Women Living with HIV in Canada: A Fuzzy Cognitive Mapping Study
Authors: Skerritt Lashanda , Kaida Angela , Savoie Édénia , Sánchez Margarite , Sarmiento Iván , O’Brien Nadia , Burchell Ann N. , Bartlett Gillian , Boucoiran Isabelle , Kestler Mary , Rouleau Danielle , Loutfy Mona , de Pokomandy Alexandra
Published: July 2022

Engagement along the HIV care cascade in Canada is lower among women compared to men. We used Fuzzy Cognitive Mapping (FCM), a participatory research method, to identify factors influencing satisfaction with HIV care, their causal pathways, and relative importance from the perspective of women living with HIV. Building from a map of factors derived from a mixed-studies review of the literature, 23 women living with HIV in Canada elaborated ten categories influencing their satisfaction with HIV care. The most central and influential category was “feeling safe and supported by clinics and healthcare providers”, followed by “accessible and coordinated services” and “healthcare provider expertise”. Participants identified factors that captured gendered social and health considerations not previously specified in the literature. These categories included “healthcare that considers women’s unique care needs and social contexts”, “gynecologic and pregnancy care”, and “family and partners included in care.” The findings contribute to our understanding of how gender shapes care needs and priorities among women living with HIV.
Discovering Tuberosin and Villosol as Potent and Selective Inhibitors of AKT1 for Therapeutic Targeting of Oral Squamous Cell Carcinoma
Authors: Adnan Mohd , Jairajpuri Deeba Shamim , Chaddha Muskan , Khan Mohd Shahnawaz , Yadav Dharmendra Kumar , Mohammad Taj , Elasbali Abdelbaset Mohamed , Abu Al-Soud Waleed , Hussain Alharethi Salem , Hassan Md. Imtaiyaz
Published: July 2022

Oral squamous cell carcinoma (OSCC) is a major cause of death in developing countries because of high tobacco consumption. RAC-alpha serine-threonine kinase (AKT1) is considered as an attractive drug target because its prolonged activation and overexpression are associated with cancer progression and metastasis. In addition, several AKT1 inhibitors are being developed to control OSCC and other associated forms of cancers. We performed a screening of the IMPPAT (Indian Medicinal Plants, Phytochemistry and Therapeutics) database to discover promising AKT1 inhibitors which pass through various important filters such as ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties, physicochemical properties, PAINS (pan-assay interference compounds) filters, PASS (prediction of activity spectra for substances) analysis, and specific interactions with AKT1. Molecules bearing admirable binding affinity and specificity towards AKT1 were selected for further analysis. Initially, we identified 30 natural compounds bearing appreciable affinity and specific interaction with AKT1. Finally, tuberosin and villosol were selected as potent and selective AKT1 inhibitors. To obtain deeper insights into binding mechanism and selectivity, we performed an all-atom molecular dynamics (MD) simulation and principal component analysis (PCA). We observed that both tuberosin and villosol strongly bind to AKT1, and their complexes were stable throughout the simulation trajectories. Our in-depth structure analysis suggested that tuberosin and villosol could be further exploited in the therapeutic targeting of OSCC and other cancers after further clinical validations.
CYP3A and CYP2B6 Genotype Predicts Glucose Metabolism Disorder among HIV Patients on Long-Term Efavirenz-Based ART: A Case-Control Study
Authors: Tadesse Wondmagegn Tamiru , Mlugu Eulambius Mathias , Shibeshi Workineh , Degu Wondwossen Amogne , Engidawork Ephrem , Aklillu Eleni
Published: July 2022

Long-term antiretroviral treatment (cART) increases the risk of glucose metabolism disorders (GMDs). Genetic variation in drug-metabolizing enzymes and transporters may influence susceptibility to cART-associated GMDs. We conducted a case-control study to investigate the association of pharmacogenetic variations with cART-induced GMDs. A total of 240 HIV patients on long-term efavirenz-based cART (75 GMD cases and 165 controls without GMDs) were genotyped for CYP3A4*1B, CYP3A5 (*3,*6), CYP2B6*6, UGT2B7*2, ABCB1 (c.3435C>T, c.4036A>G), and SLCO1B1 (*1b, *5). GMD cases were defined as the presence of impaired fasting glucose, insulin resistance, or diabetes mellitus (DM). Case-control genotype/haplotype association and logistic regression analysis were performed by adjusting for age, sex, and BMI. The major CYP3A haplotype were CYP3A5*3 (53.8%), CYP3A4*1B (17.3%), combinations of CYP3A4*1B, and CYP3A5*6 (10.9%), and CYP3A wild type (7%). CYP3A5*6 allele (p = 0.005) and CYP3A5*6 genotype (p = 0.01) were significantly associated with GMD cases. Multivariate analysis indicated CYP3A haplotype as a significant predictor of GMD (p = 0.02) and IFG (p = 0.004). CYP2B6*6 significantly predicted DM (p = 0.03). CYP3A haplotype and CYP2B6*6 genotype are independent significant predictors of GMD and DM, respectively, among HIV patients on long-term EFV-based cART.
Distal Radius Fracture with Ipsilateral Elbow Dislocation: A Rare but Challenging Injury
Authors: Bäcker Henrik C. , Thiele Kathi , Wu Chia H. , Moroder Philipp , Stöckle Ulrich , Braun Karl F.
Published: July 2022

Distal radius fractures are common and account for approximately 14% to 18% of all adult extremity injuries. On rare occasions, ipsilateral elbow dislocation can be observed additionally. However, this can be missed without careful examination, especially in patients experiencing altered mental status. The aim of this study was to analyze the mechanism, level of injury, demographics, and associated injuries in distal radius fracture with ipsilateral elbow dislocation. Between 2012 and 2019, we searched our trauma database for distal radius fracture with ipsilateral elbow dislocation. All patients older than 18 years old were included. Data on demographics, mechanism of injury, level of energy, and subsequent treatment were collected. A total of seven patients were identified. The mean age in this cohort was 68.7 ± 13.3 years old, and the left side was involved in 71.4% of the patients. Females were affected in 85.7% (n = 6/7) of cases, all of whom suffered from low-energy monotrauma at a mean age of 71.5 ± 12.3 years old. One male patient suffered from high-energy trauma (52 years old). Mainly, posterior elbow dislocations were observed (66.7%; n = 4/6). Distal radius fracture patterns, in accordance with the AO classification, included two C2-, two C3-, one C1-, and one B1-type fractures. In the patient suffering from high-energy trauma, the closed distal radius fracture was classified as type C3. Associated injures included open elbow dislocation, ulnar artery rupture, and damage to the flexor digitorum superficialis. Although distal radius fracture with ipsilateral elbow dislocation is thought to be from high-energy trauma, this study shows that most patients were elderly females suffering from low-energy mechanisms. It is important for clinicians to maintain a high level of suspicion for any concomitant injury in this population.
Cumulative Tree Mortality from Commercial Thinning and a Large Wildfire in the Sierra Nevada, California
Authors: Baker Bryant C. , Hanson Chad T.
Published: July 2022

Debate remains about the effectiveness of commercial thinning as a wildfire management strategy, with some studies reporting somewhat lower severity in thinned forests, and some reporting higher severity, during wildfires. However, while vegetation severity is a measure of basal area tree mortality, research on this question generally omits tree mortality from thinning itself. We investigated whether cumulative tree mortality, or cumulative severity, from commercial thinning and wildfire was different between thinned and unthinned forests in the Caldor Fire of 2021 in the northern Sierra Nevada mountains of California, USA. We found significantly higher cumulative severity in commercial thinning areas compared to unthinned forests. More research is needed to determine whether cumulative severity is higher in commercially thinned forests in other large western US wildfires.
Identification of Urban Functional Areas and Their Mixing Degree Using Point of Interest Analyses
Authors: Li Ya , Liu Chunxia , Li Yuechen
Published: July 2022

With the rise of smart cities and geographic big-data applications, the refined identification of urban functional areas is of great significance for decision-makers to formulate scientific and reasonable urban planning. In this paper, a random forest algorithm was adopted to analyze Point of Interest (POI) data, with the aim of identifying the functional zoning of Chongqing’s central urban area and to quantify the functional mixing degree by combining POI data with Open Street Map (OSM) road networks. The main conclusions include: (1) Due to the topography and previous urban planning strategies, the central urban area of Chongqing has a significant cluster development that radiates outward from the center of each district. Mixed functional areas account for about 40% of the total area, excluding non-functional areas. The land-use intensity of the central urban area is significant. (2) The mixing degree of the inner ring is generally high, while the aggregation characteristics of the outer ring are weaker. The functions of catering and transportation are dispersed and are mutually exclusive from other functions. (3) The identification of residential service and green spaces and squares was the best, while the identification of catering service areas was slightly less accurate. The overall identification accuracy of the single-function areas was 82%. The results of functional zoning provide valuable information for understanding the downtown area of Chongqing and represent a new method for the study of urban structures in the future.
The Surgical Treatment of Osteoarthritis
Authors: Brumat Peter , Kunšič Ožbej , Novak Samo , Slokar Urban , Pšenica Janez , Topolovec Matevž , Mihalič Rene , Trebše Rihard
Published: July 2022

Osteoarthritis is a degenerative condition affecting the whole joint with the underlying bone, representing a major source of pain, disability, and socioeconomic cost worldwide. Age is considered the strongest risk factor, albeit abnormal biomechanics, morphology, congenital abnormality, deformity, malalignment, limb-length discrepancy, lifestyle, and injury may further increase the risk of the development and progression of osteoarthritis as well. Pain and loss of function are the main clinical features that lead to treatment. Although early manifestations of osteoarthritis are amenable to lifestyle modification, adequate pain management, and physical therapy, disease advancement frequently requires surgical treatment. The symptomatic progression of osteoarthritis with radiographical confirmation can be addressed either with arthroscopic interventions, (joint) preservation techniques, or bone fusion procedures, whereas (joint) replacement is preferentially reserved for severe and end-stage disease. The surgical treatment aims at alleviating pain and disability while restoring native biomechanics. Miscellaneous surgical techniques for addressing osteoarthritis exist. Advanced computer-integrated surgical concepts allow for patient personalization and optimization of surgical treatment. The scope of this article is to present an overview of the fundamentals of conventional surgical treatment options for osteoarthritis of the human skeleton, with emphasis on arthroscopy, preservation, arthrodesis, and replacement. Contemporary computer-assisted orthopaedic surgery concepts are further elucidated.
Research on Tooth Flank Twist Based on Orthogonal Polynomials Characterization
Authors: Zhao Baoya , Yu Bo , Shi Zhaoyao , Sun Yanqiang , Wu Guoqing
Published: July 2022

Tooth flank twist is a common phenomenon in the helical crowning modification of helical cylindrical gear, which reduces the performance of the gear. At present, the measurement of tooth flank twist is still in the stage of replacing surface with line. The development of 3-D measurement technology makes the acquisition of gear information more comprehensive and complete. By processing the 3-D point cloud data, the twist deviation on the tooth flank can be found, which is particularly important for improving the quality of the tooth flank. In this paper, a characterization method of tooth flank twist based on orthogonal polynomials was proposed, which can effectively separate the twist deviations existing on the tooth flank. The correctness of the method was verified by measurement experiments. Taking worm grinding wheel grinding to process helical crowning modification as an example, the model of various parameters of the gear and the amount of twist was established and the twist deviation in processing was predicted. This provides a new method for eliminating the twist deviation of the tooth flank.
Frequency Analysis of the Railway Track under Loads Caused by the Hunting Phenomenon
Authors: Hurtado-Hurtado Gerardo , Morales-Velazquez Luis , Valtierra-Rodríguez Martín , Otremba Frank , Jáuregui-Correa Juan C.
Published: July 2022

Hunting is a potentially dangerous phenomenon related to the lateral oscillation of the wheels that impacts the rails and causes the wear of the infrastructure’s components. Therefore, the analysis and timely detection of hunting can lead to the application of corrective maintenance tasks, reducing damages, and costs and even derailments as a result. In this work, the vibration response of a finite element model of a rail with hunting-induced loads by a single wheel is analyzed in three directions: longitudinal, lateral, and vertical. The contact patch forces are calculated by means of Simpack® using the Kalker linear theory and the contact Hertz theory. The system is solved by using the Newmark-β approach. The results of the deflection and vibration analysis, following the proposed methodology, show how the different characteristics of the loads impact the rail.
Freezing Sets for Arbitrary Digital Dimension
Authors: Boxer Laurence
Published: July 2022

The study of freezing sets is part of the theory of fixed points in digital topology. Most of the previous work on freezing sets is for digital images in the digital plane Z2. In this paper, we show how to obtain freezing sets for digital images in Zn for arbitrary n, using the c1 and cn adjacencies.
On the Fuzzy Solution of Linear-Nonlinear Partial Differential Equations
Authors: Osman Mawia , Xia Yonghui , Omer Omer Abdalrhman , Hamoud Ahmed
Published: July 2022

In this article, we present the fuzzy Adomian decomposition method (ADM) and fuzzy modified Laplace decomposition method (MLDM) to obtain the solutions of fuzzy fractional Navier–Stokes equations in a tube under fuzzy fractional derivatives. We have looked at the turbulent flow of a viscous fluid in a tube, where the velocity field is a function of only one spatial coordinate, in addition to time being one of the dependent variables. Furthermore, we investigate the fuzzy Elzaki transform, and the fuzzy Elzaki decomposition method (EDM) applied to solving fuzzy linear-nonlinear Schrodinger differential equations. The proposed method worked perfectly without any need for linearization or discretization. Finally, we compared the fuzzy reduced differential transform method (RDTM) and fuzzy homotopy perturbation method (HPM) to solving fuzzy heat-like and wave-like equations with variable coefficients. The RDTM and HPM solutions are simpler than other already existing methods. Several examples are provided to illustrate the methods that have been offered. The results obtained using the scheme presented here agree well with the analytical solutions and the numerical results presented elsewhere. These studies are important in the context of the development of the theory of fuzzy partial differential equations.
Progress for Co-Incorporation of Polydopamine and Nanoparticles for Improving Membranes Performance
Authors: Abounahia Nada , Qiblawey Hazim , Zaidi Syed Javaid
Published: July 2022

Incorporating polydopamine has become a viable method for membrane modification due to its universality and versatility. Fillers in their different categories have been confirmed as effective elements to improve the properties of membranes such as hydrophilicity, permeability, mechanical strength, and fouling resistance. Thus, this paper mainly highlights the recent studies that have been carried out using polydopamine and nanomaterial fillers simultaneously in modifying the performance of different membranes such as ultrafiltration, microfiltration, nanofiltration, reverse osmosis, and forward osmosis membranes according to the various modification methods. Graphene oxide nanoparticles have recently attracted a lot of attention among different nanoparticles used with polydopamine, due to their impressive characteristics impacts on enhancing membrane hydrophilicity, mechanical strength, and fouling resistance. Thus, the incorporation techniques of graphene oxide nanoparticles and polydopamine for enhancing membranes have been highlighted in this work. Moreover, different studies carried out on using polydopamine as a nanofiller for optimizing membrane performance have been discussed. Finally, perspectives, and possible paths of further research on mussel-inspired polydopamine and nanoparticles co-incorporation are stated according to the progress made in this field. It is anticipated that this review would provide benefits for the scientific community in designing a new generation of polymeric membranes for the treatment of different feed water and wastewater based on adhesive mussel inspired polydopamine polymer and nanomaterials combinations.
Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications
Authors: Haro-Reyes Tammy , Díaz-Peralta Lucero , Galván-Hernández Arturo , Rodríguez-López Anahi , Rodríguez-Fragoso Lourdes , Ortega-Blake Iván
Published: July 2022

This review examined a collection of studies regarding the molecular properties of some polyene antibiotic molecules as well as their properties in solution and in particular environmental conditions. We also looked into the proposed mechanism of action of polyenes, where membrane properties play a crucial role. Given the interest in polyene antibiotics as therapeutic agents, we looked into alternative ways of reducing their collateral toxicity, including semi-synthesis of derivatives and new formulations. We follow with studies on the role of membrane structure and, finally, recent developments regarding the most important clinical applications of these compounds.
A Novel Anaerobic Gravity-Driven Dynamic Membrane Bioreactor (AnGDMBR): Performance and Fouling Characterization
Authors: Pu Yingfei , Fu Zihan , Li Tingting , Chen Yucheng , Zhou Zhongbo
Published: July 2022

Despite numerous studies undertaken to define the development and significance of the dynamic membrane (DM) formed on some coarse materials, the optimization of reactor configuration and the control of the membrane fouling of anaerobic dynamic membrane bioreactor (AnDMBR) need to be further investigated. The aim of this study was to design a novel anaerobic gravity-driven dynamic membrane bioreactor (AnGDMBR) for the effective and low-cost treatment of municipal wastewater. An 800 mesh nylon net was determined as the optimal support material based on its less irreversible fouling and higher effluent quality by the dead-end filtration experiments. During the continuous operation period of 44 days, the reactor performance, DM filtration behavior and microbial characteristics were studied and compared with the results of recent studies. AnGDMBR had a higher removal rate of chemical oxygen demand (COD) of 85.45 ± 7.06%. Photometric analysis integrating with three-dimensional excitation–emission matrix fluorescence spectra showed that the DM effectively intercepted organics (46.34 ± 16.50%, 75.24 ± 17.35%, and 66.39 ± 17.66% for COD, polysaccharides, and proteins). The addition of suspended carriers effectively removed the DM layer by mechanical scouring, and the growth rate of transmembrane pressure (TMP) and the decreasing rate of flux were reduced from 18.7 to 4.7 Pa/h and 0.07 to 0.01 L/(m2·h2), respectively. However, a dense and thin morphological structure of the DM layer was still observed in the end of reactor operation and plenty of filamentous microorganisms (i.e., SJA-15 and Anaerolineaceae) and the acidogens (i.e., Aeromonadaceae) predominated in the DM layer, which was also embedded in the membrane pore and led to severe irreversible fouling. In summary, the novel AnGDMBR has a superior performance (higher organic removal and lower fouling rates), which provides useful information on the configuration and operation of AnDMBRs for municipal wastewater treatment.
Critical Conditions for Dynamic Recrystallization of S280 Ultra-High-Strength Stainless Steel Based on Work Hardening Rate
Authors: Liu Mutong , Tian Ye , Wang Yu , Wang Kelu , Zhang Kaiming , Lu Shiqiang
Published: July 2022

Isothermal and constant-strain-rate compression experiments for S280 ultra-high-strength stainless steel were carried out under deformation temperatures of 1000–1150 °C and strain rates of 0.001–10 s−1 with a Thermecmaster-Z thermal simulator. The flow–stress behavior of the alloy was studied and the hot deformation activation energy was calculated. A critical strain model of the dynamic recrystallization (DRX) of the alloy was established using the work hardening rate for the first time. The results show that S280 ultra-high-strength stainless steel was positively sensitive to the strain rate and negatively sensitive to temperature, and its flow–stress curve showed characteristics of flow softening. The hot deformation activation energy corresponding to the peak strain was 519.064 kJ/mol. The DRX critical strain of the steel was determined from the minimum value of the −∂(lnθ)/∂ε − ε curve. The relationship between the DRX critical strain and peak strain could be characterized as εc=0.599εp and the relationship between the DRX critical stress and peak stress could be characterized as σc= 0.959σp The critical strain model of DRX could be expressed as εc=0.010Z0.062. The research results can provide theoretical support for avoiding the generation of actual thermal processing microstructure defects such as coarse grains and for obtaining products with excellent microstructure and properties.
Antioxidant and Neuroprotective Activity of Vitamin E Homologues: In Vitro Study
Authors: Trela-Makowej Agnieszka , Leśkiewicz Monika , Kruk Jerzy , Żądło Andrzej , Basta-Kaim Agnieszka , Szymańska Renata
Published: July 2022

Here we present comparative data on the inhibition of lipid peroxidation by a variety of tocochromanols in liposomes. We also show for the first time the potential neuroprotective role of all the vitamin E homologues investigated on the neuronally differentiated human neuroblastoma SH-SY5Y cell line. α-Tocopherol had nearly no effect in the inhibition of lipid peroxidation, while β-, γ-, and δ-tocopherols inhibited the reaction completely when it was initiated in a lipid phase. Similar effects were observed for tocotrienol homologues. Moreover, in this respect plastochromanol-8 was as effective as β-, γ-, and δ-tocochromanols. When the prenyllipids were investigated in a 1,1-diphenyl-2-picrylhydrazyl (DPPH) test and incorporated into different lipid carriers, the radical oxidation was most pronounced in liposomes, followed by mixed micelles and the micellar system. When the reaction of tocochromanols was examined in niosomes, the oxidation was most pronounced for α-tocopherol and plastochromanol-8, followed by α-tocotrienol. Next, using retinoic acid-differentiated SH-SY5Y cells, we tested the protective effects of the compounds investigated on hydrogen peroxide (H2O2)-induced cell damage. We showed that tocotrienols were more active than tocopherols in the oxidative stress model. Plastochromanol-8 had a strong inhibitory effect on H2O2-induced lactate dehydrogenase (LDH) release and H2O2-induced decrease in cell viability. The water-soluble α-tocopherol phosphate had neuroprotective effects at all the concentrations analyzed. The results clearly indicate that structural differences between vitamin E homologues reflect their different biological activity and indicate their potential application in pharmacological treatments for neurodegenerative diseases. In this respect, the application of optimal tocochromanol-carrying structures might be critical.