bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of the Glycine Receptor β Subunit in Synaptic Localization and Pathogenicity in Severe Startle Disease
Authors: Wiessler Anna-Lena , Hasenmüller Ann-Sofie , Fuhl Isabell , Mille Clémence , Cortes Campo Orlando , Reinhard Nicola , Schenk Joachim , Heinze Katrin G. , Schaefer Natascha , Specht Christian G. , Villmann Carmen
Published: November 2023

Startle disease is due to the disruption of recurrent inhibition in the spinal cord. Most common causes are genetic variants in genes (
GLRA1
,
GLRB
) encoding inhibitory glycine receptor (GlyR) subunits. The adult GlyR is a heteropentameric complex composed of α1 and β subunits that localizes at postsynaptic sites and replaces embryonically expressed GlyRα2 homomers. The human GlyR variants of
GLRA1
and
GLRB
, dominant and recessive, have been intensively studied in vitro. However, the role of unaffected GlyRβ, essential for synaptic GlyR localization, in the presence of mutated GlyRα1 in vivo is not fully understood. Here, we used knock-in mice expressing endogenous mEos4b-tagged GlyRβ that were crossed with mouse
Glra1
startle disease mutants. We explored the role of GlyRβ under disease conditions in mice carrying a missense mutation (
shaky
) or resulting from the loss of GlyRα1 (
oscillator
). Interestingly, synaptic targeting of GlyRβ was largely unaffected in both mouse mutants. While synaptic morphology appears unaltered in
shaky
animals, synapses were notably smaller in homozygous
oscillator
animals. Hence, GlyRβ enables transport of functionally impaired GlyRα1 missense variants to synaptic sites in
shaky
animals, which has an impact on the efficacy of possible compensatory mechanisms. The observed enhanced GlyRα2 expression in
oscillator
animals points to a compensation by other GlyRα subunits. However, trafficking of GlyRα2β complexes to synaptic sites remains functionally insufficient, and homozygous
oscillator
mice still die at 3 weeks after birth. Thus, both functional and structural deficits can affect glycinergic neurotransmission in severe startle disease, eliciting different compensatory mechanisms in vivo.
Conditional Astrocyte Rac1KO Attenuates Hyperreflexia after Spinal Cord Injury
Authors: Benson Curtis A. , Olson Kai-Lan , Patwa Siraj , Kauer Sierra D. , King Jared F. , Waxman Stephen G. , Tan Andrew M.
Published: November 2023

Spasticity is a hyperexcitability disorder that adversely impacts functional recovery and rehabilitative efforts after spinal cord injury (SCI). The loss of evoked rate-dependent depression (RDD) of the monosynaptic H-reflex is indicative of hyperreflexia, a physiological sign of spasticity. Given the intimate relationship between astrocytes and neurons, that is, the tripartite synapse, we hypothesized that astrocytes might have a significant role in post-injury hyperreflexia and plasticity of neighboring neuronal synaptic dendritic spines. Here, we investigated the effect of selective Rac1KO in astrocytes (i.e., adult male and female mice, transgenic cre-flox system) on SCI-induced spasticity. Three weeks after a mild contusion SCI, control Rac1
wt
animals displayed a loss of H-reflex RDD, that is, hyperreflexia. In contrast, transgenic animals with astrocytic Rac1KO demonstrated near-normal H-reflex RDD similar to pre-injury levels. Reduced hyperreflexia in astrocytic Rac1KO animals was accompanied by a loss of thin-shaped dendritic spine density on a-motor neurons in the ventral horn. In SCI-Rac1
wt
animals, as expected, we observed the development of dendritic spine dysgenesis on a-motor neurons associated with spasticity. As compared with WT animals, SCI animals with astrocytic Rac1KO expressed increased levels of the glial-specific glutamate transporter, glutamate transporter-1 in the ventral spinal cord, potentially enhancing glutamate clearance from the synaptic cleft and reducing hyperreflexia in astrocytic Rac1KO animals. Taken together, our findings show for the first time that Rac1 activity in astrocytes can contribute to hyperreflexia underlying spasticity following SCI. These results reveal an opportunity to target cell-specific molecular regulators of H-reflex excitability to manage spasticity after SCI.

Significance Statement
Spinal cord injury leads to stretch reflex hyperexcitability, which underlies the clinical symptom of spasticity. This study shows for the first time that astrocytic Rac1 contributes to the development of hyperreflexia after SCI. Specifically, astrocytic Rac1KO reduced SCI-related H-reflex hyperexcitability, decreased dendritic spine dysgenesis on a-motor neurons, and elevated the expression of the astrocytic glutamate transporter-1 (GLT-1). Overall, this study supports a distinct role for astrocytic Rac1 signaling within the spinal reflex circuit and the development of SCI-related spasticity.
Single‐cell transcriptomics stratifies organoid models of metabolic dysfunction‐associated steatotic liver disease
Authors: Hess Anja , Gentile Stefan D , Ben Saad Amel , Rahman Raza‐Ur , Habboub Tim , Pratt Daniel S , Mullen Alan C
Published: November 2023

Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a growing cause of morbidity with limited treatment options. Thus, accurate in vitro systems to test new therapies are indispensable. While recently, human liver organoid models have emerged to assess steatotic liver disease, a systematic evaluation of their translational potential is still missing. Here, we evaluated human liver organoid models of MASLD, comparatively testing disease induction in three conditions: oleic acid, palmitic acid, and TGF‐β1. Through single‐cell analyses, we find that all three models induce inflammatory signatures, but only TGF‐β1 promotes collagen production, fibrosis, and hepatic stellate cell expansion. In striking contrast, oleic acid ameliorates fibrotic signatures and reduces the hepatic stellate cell population. Linking data from each model to gene expression signatures associated with MASLD disease progression further demonstrates that palmitic acid and TGF‐β1 more robustly model inflammation and fibrosis. Our findings highlight the importance of stratifying MASLD organoid models by signatures of clinical disease progression, provide a single‐cell reference to benchmark future organoid injury models, and allow us to study evolving steatohepatitis, fibrosis, and HSC susceptibility to injury in a dynamic, multi‐lineage human in vitro system.
Thermo-Economic Performance of Organic Rankine Cycle-Based Waste Heat Recovery for Power Generation at a Wide Range of Operating Conditions
Authors: Gerutu Gerutu B. , Kivugo Ramadhani O. , Lujaji Frank , Chombo Pius V.
Published: November 2023

This study assesses the performance of organic Rankine cycle-based waste heat recovery systems under different working fluids and operating conditions. The basic ORC (BORC) and ORC with recuperator (RORC) are investigated for power generation and economy using toluene and benzene. Thermodynamic and economic indicators are studied at various expander inlet temperatures, expander inlet pressure, evaporation temperature, and condensation temperature. RORC achieves higher ηth by reducing heat source in the evaporator whereas BORC recovers more waste heat and improves Pnet. With toluene, BORC improves Pnet when increasing the expander inlet temperature and pressure. The lowest LCOE of 0.0532 US$/kWh is from BORC operated with toluene at a Pnet of 349 kW and decreases with an increase in expander inlet temperature. The addition of a recuperator adds to the costs of initial investment and LCOE and slightly improves the performance of the ORCs for waste heat recovery.
Specificities of accumulation of essential polyunsaturated fatty acids of ω-3 and ω-6 families in the tissues of bulls after supplementing their diet with the sources of fatty acids and mineral elements
Authors: Diachenko O. B. , Rivis J. F. , Tesak G. V. , Stadnytska O. I.
Published: November 2023

Aim. To determine the intensity of growth of fattening bulls and the specificities of the accumulation of essential polyunsaturated
fatty acids from the ω-3 and ω-6 families in their tissues after supplementing their diet with the sources
of essential fatty acids and copper sulfate to increase their meat productivity and improve the biological value of beef.
Methods. The study was conducted using the methodological approaches, common for international practice in accordance
with the requirements of ISO 17025, and using the conventional methods of peer groups involving clinically
healthy animals. The content of polyunsaturated fatty acids of the ω-3 and ω-6 families was determined by gas chro-
matography using the Chrom-5 device. Copper content was determined by the method of atomic absorption spectro-
photometry using the Selmi C-115 M1 device. Results. It was found that the introduction of linseed oil (as a source of
α-linolenic acid, which is a precursor of polyunsaturated fatty acids of the ω-3 family) and sunflower oil (as a source
of linoleic acid, which is a precursor of polyunsaturated fatty acids of the ω-6 family), the synthetic substance doxane
(as an inhibitor of biohydrogenation processes in unsaturated fatty acids in the rumen) and pentahydrate copper sulfate
(as a source of copper) to the diet of young fattening cattle caused a probable increase in the content of biologically
active polyunsaturated fatty acids of the ω-3 and ω-6 family and copper in their liver and skeletal muscles. At the same
time, the increase in the content of biologically active polyunsaturated fatty acids of the ω-3 and ω-6 families and copper
in the abovementioned tissues due to the stimulation of metabolic processes in the body contributed to a probable
increase in the average daily weight gain of young fattening animals. Thus, there was a direct relationship between the
content of α-linolenic and linoleic acids and copper in the diet and their content in the tissues of experimental animals,
productivity characteristics, and biological value of beef. Conclusions. The introduction of a mixture of linseed and
sunflower oils into the diet of fattening bulls led to an increase in the content of α-linolenic and linoleic acids and a
1.7-fold decrease in the ratio between essential polyunsaturated fatty acids of the ω-6 family and that of the ω-3 family.
The increase in the content of copper and essential polyunsaturated fatty acids of the ω-6 and ω-3 families in the
diet of fattening bulls led to their accumulation in the liver and skeletal muscles, which contributed to the enhanced
biological value of beef.
Sufism Literature: Divinity Philosophy in Taufiq al-Hakim’s Short Story Arinillah
Authors: Zulhelmi Zulhelmi , Nurchalish Nurchalish , Syarifuddin Syarifuddin , Walidin Muhammad , Muskar Rahlina
Published: November 2023

PurposeThis article aimed to know how a Modern Egyptian writer, Taufiq al-Hakim, enlightened his readers to believe Allah's existence and could feel His presence more closely. MethodAs qualitative research, this article relied on verbal data in the form of sentences or paragraphs available in the short story. In collecting the data, the authors read carefully Arinillah, Taufiq al-Hakim’s short story; and made some notes on sentences or paragraphs considered to indicate ways of enlightening Allah’s existence. The data were analyzed qualitatively using Sufism literature theories to identify Taufiq al-Hakim’s ideas of Allah’s existences and his ways of educating the readers to believe in Allah. Results/FindingsTaufiq al-Hakim's ways of educating his readers to believe in Allah’s existence through the storyline beginning with curiosity and ending with regret. He did not curb the readers’ curiosity to know Allah's existence, but left them to play in the adventure of Sufistic spiritual imagination. At the end of the story, they regretted because they with their mind were not able to identify the existence of Allah, the greatest. ConclusionThe article concluded that Arinillah storyline was Taufiq al-Hakim’s way in interpreting hadith of the Prophet Muhammad SAW regarding prohibition to think Allah’s substance; and it was not true that he violated such a prohibition.
Marriage and Women's Subalternity in the Ecranisation of Layla Majnun’s Story
Authors: Junaidi Ahmad Syafa'at , Rusdiarti Suma Riella
Published: November 2023

PurposeThis article aimed to explain the textual changes in adapting Layla Majnun's story to the film Layla Majnun (2021). In addition, this article questioned the textual ideology of both works con-cerning marriage and women's subalternity.MethodThis article was qualitative research using the literature method. The corpus of this article were the novel Layla Majnun by Nizami Ganjavi and the film Layla Majnun (2021) by Monty Tiwa. This article used Linda Hutcheon's adaptation theory, the concept of subaltern initiated by Ga-yatri C. Spivak, and feminist concepts related to marriage.Results/FindingsThe results of this article show significant changes in the form of the adaptation of the story of Layla Majnun to the film. The changes are in the form of narrative structure, the meaning of mar-riage, and women's voices. The story of Layla Majnun focuses more on the storytelling of male characters, while the film focuses more on the storytelling of female characters.ConclusionThe textual shift from novel to film influences changes in the ideology of the text concerning mar-riage and women's subalternity. In the Layla Majnun novel, women are unable to speak out (subaltern) against repression from men concerning marriage. At the same time, the film Layla Majnun attempts to bring out women's voices to articulate their will in marriage.
Diversity of early flowering plants of the Ulytau mountains (Central Kazakhstan)
Authors: Pozdnyakova Y. , Sailau A. , Solyanov D. , Aitisheva L. , Tatina Y. , Britko V.
Published: November 2023

Early flowering plants (ephemers and ephemeroids) are an important component of the biosystem of steppes and deserts. These species form perennial pasture communities, for early grazing. The present work was conducted to evaluate the floristic checklist and ecological uniqueness of early flowering plants of Central Kazakhstan, in the forest-steppe regions of Em-Bulak region and Edige mountains, during 2021 and 2022. A total of 26 species of ephemers and ephemeroids were recorded, which belong to 16 families: Liliaceae – 3 species, Asteraceae – 3 species, Ranunculaceae – 3 species, Rosaceae – 3 species, Brassicaceae – 2 species, Boraginaceae – 2 species, the other families are represented by one species. According to ecomorphological characteristics: 8 species (31%) belong to the xerophyte group, 6 (23%) to the xeromesophyte group, 7 (27%) to the mesoxerophyte group and 5 (19%) to the mesophyte group. Also, as a result of our research we found two species of plants which are included in the Red Book of the Republic of Kazakhstan – Pulsatilla patens (L.) Mill. and Tulipa patens Agardh. ex Schult. f. The data obtained can be used for environmental monitoring and issues of rational nature management of wild plants of Central Kazakhstan.
Decorative perennials of the regional flora for recreation landscapes in the forest-steppe zone
Authors: Matyashuk R. K. , Pirko I. F. , Gubar L. M. , Tkachenko I. V.
Published: November 2023

This work is devoted to the preservation of biodiversity and the prospects of its integration into projects for the improvement of recreational landscapes and greening facilities of modern cities. It is a continuation of the study of the bioecological potential of regional plant resources for landscaping recreational areas. To represent the existing plant diversity of the forest-steppe zone of Ukraine, a fund of species of decorative perennials was used. At this stage of the research, the decorative and bioecological characteristics of 147 herbaceous perennials of the spontaneous flora of the Feofania tract are given, which determine their economic value. The phenorhythmotypical composition, ecological and cenotic timing, colour spectrum and seasonal colour dynamics were considered. The phenorhythmotypical spectrum of this artificial population is shown, in which long-vegetating species predominate, ensuring the formation of compositions with a closed grass stand and a continuous and long-lasting decorative effect. Critical, from the point of view of competitive relationships, a group of species characterized by active dispersal is identified and options for their optimal use are presented. The ecological and cenotic diversity of the studied population, which is representative for the forest-steppe zone, is shown, which makes it possible to select the optimal multi-component assortment for areas with different ecological conditions. The colour spectrum of the studied group and its dynamics during the growing season, which are comparable for geophilic and sciophilous species, are considered. A conceptual approach to the selection of promising species of regional flora for the creation of decorative locations in city parks is considered. In general, the expediency of using local plant resources as an optimal source of forming a basic assortment of decorative perennials for regional landscaping is shown on the example of the study of some aspects of the aesthetic and bioecological potential of decorative perennials of the spontaneous flora of the Feofania tract. We consider the integration of the existing biodiversity of the regional flora into the architectural environment an important practical component of biodiversity conservation.
Resistance of plant life forms of native and regenerated alpine plant communities to experimental trampling
Authors: Piscová V. , Sedlák A. , Ševčík M. , Hreško J. , Slobodová T. , Petrovič F.
Published: November 2023

Trampling of vegetation as a result of recreation can adversely affect natural habitats, leading to loss of vegetation and degradation of plant communities. Many studies indicated that intrinsic properties of plant communities appear to be the most important factors determining the response of vegetation to trampling disturbance. Specifically, the dominant life-form of a plant community accounts for more variation in the resistance of communities to trampling than the intensity of the trampling experienced, suggesting that simple assessments based on this trait could guide decisions on access to natural sites. We verify these claims in the Belianske Tatry National Nature Reserve in Slovakia, which has been closed since 1978 due to destruction by mass tourism, with the exception of one trail made accessible since 1993. In researching the resistance of communities according to dominant life forms we adjusted the number of passes according to the minimum (75 tourists) and maximum (225 tourists) daily visitation during the tourist season. The studied communities occur in close proximity to the trails on the saddles through which the open trail passes. Available evidence from our studies suggests that vegetation dominated by hemicryptophytes is more resistant to trampling and recovers from trampling to a greater extent than vegetation dominated by other life forms. Therefore, we selected three alpine communities dominated by hemicryptophytes. In the Juncetum trifidi community, they almost completely dominate, they are mainly composed of grasses. Although they dominate the Junco trifidi-Callunetum vulgaris community, the species, Calluna vulgaris has been added to the woody chamephytes, and thus the woody Chamaephytes achieve a higher cover than in the Juncetum trifidi community. Although in the community Seslerietum tatrae biscutelletosum laevigatae hemicryptophytes dominate, it consists of several plant life forms and its grasses reach greater heights than in previous communities. We found that it is not possible to estimate the resilience of communities to trampling by dominant life forms. Life forms within one community react very similarly, but this statement cannot be generalized globally for all communities. At the same time, we found that if we damage the native community, which subsequently regenerates, the life forms of the community behave differently when damaged repeatedly. More detailed research is needed worldwide, which would point out patterns of behaviour of alpine plant vegetation to trampling.
Changes in the Carpathian fauna of Malachiinae beetles (Coleoptera, Melyridae) in the context of temperature increase
Authors: Mirutenko V. V. , Lovas P. S. , Roshko V. G. , Felbaba-Klushyna L. M.
Published: November 2023

Over last century in Europe a tendency of change in species ranges has occurred for insects of different taxonomic groups. We analyzed the changes that have taken place in the distribution of some soft-winged beetles (Malachiinae, Melyridae) species in the Carpathian region. The obtained data are based on a study of museum beetles’ collections and the authors’ collected materials. Data comparison relating to species distribution shows that the Carpathian fauna during the second half of the 20th century increased by 12 species. Some species have significantly changed their ranges. Species of Southern European and Mediterranean (Anthomalachius strangulatus, Clanoptilus spinipennis), Central-East European (Apalochrus femoralis, Clanoptilus falcifer) origin spread to the East Carpathian region. And vice versa, some species (e.g. Malachius scutellaris) from Central European and the Carpathian regions have spread beyond their borders of ranges to the East and North. Malachiinae species are anthophilic insects. Their life cycles, flight period, and distribution depend on the phenology of host plants. Acceleration of phenophases of the host plants and intensification of the metamorphosis processes due to increase in air temperature has caused an earlier appearance of soft-winged beetles in recent years and contributed to expansion of the ranges of some species of them. In our opinion, expansion of the species ranges and penetration of new beetle species into the Carpathian region from surrounding areas are related to the climate changes, in particular to warming. This thesis is confirmed by multiyear air temperature data of the Transcarpathian Centre of Hydrometeorology. On a background of increase in regional air temperature by about 0.8 °C an average air temperature in foothills of Ukrainian Carpathians has increased by 1.7 °C during last 50–60 years.
Role of self-curing mechanism in lightweight concrete: A state-of-the-art report
Authors: Sundaramoorthy Ganesan , Meyyappan Palaniappan
Published: November 2023

Worldwide, precast and hybrid construction methods are becoming increasingly popular in the construction industry. But many problems occur during the fabrication, such as segregation, bleeding, scaling, plastic shrinkage, dust formation, honeycombing, sintering, high sorptivity, and high permeability and transportation. This problem may be caused by an ineffective curing process that affects the quality of concrete and construction. In addition, it provides inadequate and incomplete cement hydration that has a 20% negative effect on the desired properties of the concrete. Various researchers have demonstrated the components of self-curing lightweight concrete that can enhance strength and physicochemical properties, and address the above-mentioned issues. In this review, the role of the self-curing mechanism in lightweight concrete based on the various self-curing chemical admixtures such as polyethylene glycol (PEG), superabsorbent polymer (SAP), polyvinyl alcohol (PVA), sodium lignosulfonate and calcium lignosulfonate as self-curing agents are discussed in detail. Also, this paper briefly reports on the scope, significance, mechanisms, and tests for self-curing lightweight concrete. Overall, this review analyzes the possibilities of future research perspectives on self-curing lightweight concrete with sustainable materials and fibres with comparative technical information.
Peran dan Kontribusi Syaikh Nawawi Al-Bantani dalam Kajian Hadis di Indonesia
Authors: Raffi’u Aliyya Shauma , Kudus Abdul , Jaenudin Dindin , Hafidz Ai Raffi’ah
Published: November 2023

Shaykh Nawawi al-Bantani is one of the scholars who has made significant contributions to various fields of Islamic knowledge in Indonesia, including the hadiths of the Prophet. Therefore, this research aims to describe the role and contribution of Shaykh Nawawi al-Bantani in the field of hadith. The method used in this research is descriptive with a literature review approach. The analytical technique employed is qualitative content analysis. The results of this research include: Shaykh Nawawi al-Bantani's role and contribution to the study of hadith in the Indonesian archipelago cannot be separated from the roles of his disciples (santri) and his works, which continue to be taught to the community, especially within the environment of Islamic boarding schools (pesantren).
Infância, adolescência e TICs: uma década de pesquisa em Educação, Psicologia e Comunicação
Authors: Faustino da Silva Simone , Vitorino Sampaio Ines Silvia , Mendonça Máximo Thinayna
Published: November 2023

Este artigo objetiva mapear pesquisas de mestrado e doutorado sobre crianças, adolescentes e TICs nas áreas de Comunicação, Educação e Psicologia, nos últimos 10 anos. O levantamento usou as bases de dados da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) e do Instituto Brasileiro de Informação em Ciência e Tecnologia (IBICT). Foram analisados 215 trabalhos, a partir de categorias temáticas, sujeitos de pesquisa, metodologia e técnicas de coleta de dados. A análise revelou que “acesso e uso”, “mediação”, “apropriação”, “aprendizagem” e “consumo” foram as temáticas mais abordadas pelas três áreas. Adolescentes são os sujeitos prioritários, seguidos por crianças e professores. Prevalecem pesquisas qualitativas, e as metodologias e métodos mais utilizados foram etnografia, pesquisa exploratória, estudo de caso, pesquisa participante e análise de conteúdo.
Trajetória dos gastos sociais, pobreza e desigualdade no Ceará no período de 2008 a 2021
Authors: Alves Christiane Luci Bezerra , Pinheiro Valéria Feitosa , Franca Adriana Correia Lima , Waltenberg Fábio Domingues
Published: November 2023

O Estado, através das políticas públicas, deve garantir que os direitos fundamentais sociais do cidadão sejam atendidos, objetivando o bem-estar social e a redução das desigualdades em todas as suas modalidades. Esta investigação busca dimensionar e analisar a trajetória dos gastos sociais no Ceará, bem como aspectos sobre pobreza e desigualdade, entre 2008 e 2021. Utilizou-se, para isso, uma metodologia de base exploratório-descritiva, por meio de dados secundários do site Compara Brasil, do Instituto Brasileiro de Geografia e Estatística (IBGE) e do Instituto de Pesquisa e Estratégia Econômica do Ceará (IPECE). De maneira geral, mesmo sendo resultado da política de desenvolvimento estadual, os gastos sociais no Ceará apresentam um comportamento atrelado à conjuntura nacional, inclusive quando se observam os gastos por função. Relativo à desigualdade, o Ceará adere mais às conjunturas de recuperação ou de recessão, em comparação com o desempenho regional e nacional. A pobreza reage melhor nas conjunturas adversas, de 2014 a 2019 e no ano pandêmico de 2020. O cenário de austeridade fiscal em curso, desde 2016, e a tendência de desresponsabilização do Estado, exclusive o período pandêmico, representa um limite para o retorno da tendência de queda das condições pobreza e desigualdade, experimentadas até 2015, constituindo, adicionalmente, cenário obscuro para o exercício da política social no país.
Variación morfológica foliar de Brickellia sección Barroetea (A. Gray) E.E. Schill. & R. Scott y especies afines
Authors: Morales-Garduño Luis , Villaseñor José Luis
Published: November 2023

Antecedentes: Las hojas han sido utilizadas para definir secciones en el género Brickellia, lo que permite postular su valor taxonómico en grupos monofiléticos, así como identificar el grado de similitud morfológica entre especies y secciones en un contexto taxonómico y filogenético. 

Preguntas: ¿Las especies de Brickellia sección Barroetea se pueden diferenciar con las formas de las láminas foliares? ¿La sección se reconoce de las demás secciones del género con base en la forma foliar?, ¿las formas foliares son un rasgo conservado en el género Brickellia?

Especies de estudio: Se utilizaron seis especies de la sección Barroetea y 19 especies de otras secciones de Brickellia y géneros relacionados (Ageratina y Carminatia).     

Métodos: Se realizó un análisis linear discriminante y un filomorfoespacio para conocer las diferencias y evaluar la conservación de la forma foliar.

Resultados: Las especies de la sección Barroetea presentaron diferencias significativas a nivel específico, excepto en Brickellia sonorana. Las especies evaluadas de las secciones Barroetea, Brickellia, Coleosanthus, Leptanthodium y Xerobrickellia tienden a formas ovado-deltoideas, excepto Microphyllae donde son reniformes, en Phanerostylis ovadas o elípticas y en Gemmipedium y Kuhnia lineares. El filomorfoespacio muestra un traslape entre las secciones analizadas; las secciones ancestrales muestran un cambio morfológico mayor que las secciones de reciente diversificación y la conservación de la forma foliar no se confirmó estadísticamente.

Conclusiones: La mayoría de las especies de Brickellia sección Barroetea se pueden diferenciar entre ellas, pero no de las demás secciones del género Brickellia. Las formas foliares no se conservan en las secciones del género.
Comunicación estratégica en crisis políticas: el caso de Guillermo Lasso (2023)
Authors: Chavero Palmira , Rodríguez Raquel
Published: November 2023

El incremento en el uso de las plataformas digitales y las redes sociales por parte de diferentes actores de la esfera pública se ha convertido en una de las líneas de estudio con más aportes en las últimas décadas en los estudios de la Comunicación. Su uso en momentos de crisis política revela la importancia de la comunicación estratégica de los actores políticos, puesto que la convierte en comunicación de crisis. En este trabajo analizamos la comunicación estratégica digital del expresidente de Ecuador, Guillermo Lasso, en la crisis política provocada por el juicio político en su contra (mayo 2023) y la convocatoria a elecciones anticipadas. Para ello, presentamos un análisis crítico del discurso de los tuits emitidos por el expresidente entre mayo y julio de 2023. Los resultados dan cuenta de un giro en su estrategia comunicacional digital y en su relación con el resto de actores políticos tras el anticipo electoral.
Book Review
Authors: Feez Susan
Published: November 2023

A century on, as young children in Montessori classrooms around the world continue to engage with Sandpaper Letters, Metal Insets, Moveable Alphabets, and Reading Command cards, an accumulation of studies into how children learn to read from across a range ofdisciplines has generated an influential body of research evidence that has been dubbed the science of reading. The science of reading is currently being used to shape education policy and mandated curriculum documents, especially in the English-speaking world. For this reason, the comparative analysis of the Montessori approach and the science of reading presented in Powerful Literacy inthe Montessori Classroom: Aligning Reading Research and Practice will be welcomed by many Montessori educators.
QUINT Workflow Appendix v1
Authors: X. Henderson Michael
Published: November 2023

This protocol contains additional details for the modified QUINT workflow.
Knowledge transfer interventions on cancer in Africa and Asia : a scoping review v1
Authors: Robin Julie
Published: November 2023

Introduction: Africa and Asia face many challenges related to knowledge transfer in the field of cancer diagnosis, treatment, survivorship, and end-of-life care. Some of these challenges include adherence to screening, confidence in the capabilities of modern medicine and the local health system, the ability of patients to make informed decisions about their treatment, the response of family members and society, the ability of the health system to improve the quality of survival of patients, and the ability of the authorities to implement appropriate and effective cancer control policies. It is therefore essential to understand how evidence and experiential knowledge can be better integrated into the health system and into the actions or decisions of those involved in cancer control. Objective:The aim of this scoping review is to understand the extent and nature of evidence relating to knowledge transfer interventions to improve cancer care in Africa and Asia. The results of this scoping will be used to inform an intervention research project on the knowledge transfer role of breast cancer patient organisations implemented as part of a larger project on the experiences of breast cancer patients in Mali, Benin and Cambodia. Inclusion criteria: To be eligible, an article had to be peer-reviewed research, an empirical paper, written in English or French. Articles whose objectives, primary outcomes (quantitative studies) or main theme (qualitative studies) were related to cancer knowledge transfer in Africa and Asia will be included. Articles relating to fundamental, translational and clinical research without a knowledge transfer dimension (clinical trials/randomised pilot trials studies, etc.) are excluded, as are articles on skills and technology transfer. Methods: The search strategy for the bibliographic databases will be developed by the research team in collaboration with a librarian. Embase, Emcare, ERIC, APA Psycinfo and Medline will be searched for cancer knowledge transfer interventions conducted in Africa and Asia or relating to Africa and Asia, supplemented by expert bibliography and references cited in the documents analysed. The research will cover the period from January 1978 to March 2023.The review and extraction of references (abstracts and full articles) will be carried out by the research team using Covidence. The data will be evaluated and analysed by the lead author according to an analytical grid based on the categorisation of the type of intervention, the model used for its design or implementation, the stakeholders and their modes of involvement, the limiting and facilitating factors, the evaluation of the intervention, its sustainability and replicability, and the conclusions and recommendations of the authors.
QuPath Visualization/Segmentation v1
Authors: X. Henderson Michael
Published: November 2023

This protocol describes QuPath visualization/segmentation.
Collection of Protocols for transcardial perfusion, immunohistochemistry/immunofluorescence and dual in situ hybridization v1
Authors: X. Henderson Michael
Published: November 2023

This is a collection of protocols about transcardial perfusion, immunohistochemistry/immunofluorescence and dual in situ hybridization.
Intersecting Disability and Poverty in the Global South: Barriers to the Localization of the UNCRPD
Authors: Grech Shaun , Weber Jörg , Rule Sarah
Published: November 2023

The UN Convention on the Rights of Persons with Disabilities (UNCRPD) remains in place as the major disability rights instrument recognising that all persons with disabilities must enjoy human rights and freedoms as every other person. However, the CRPD does not automatically confer realization of these rights. In practice, its implementation is met by multiple hurdles, most pronounced at the local level in the Global South, where disability and poverty intersect. This article reports on findings from a study in five countries (Kenya, Philippines, Jamaica, Guatemala, and South Africa) looking at the extent to which the CRPD is being implemented locally in contexts of poverty, and the factors and processes impacting this localization. The findings highlight multiple barriers, becoming more pronounced in local rural areas. These include weak and fragmented organisations of persons with disabilities (OPDs), political and legal issues, and a siloed approach where disability is marginalised in mainstream areas, including development. These barriers are accentuated as intersectional dimensions are factored in, including indigeneity, age, gender, race, and ethnicity. Overall, each local context is left to its own devices, with urban stakeholders, unknowing of what life in poverty is like and how this reframes the CRPD in discourse and practice at the forefront. Our study concludes that there is a profound need for an informed, contextualized, intersectional, and geopolitical analysis where poverty is kept sharply in focus. This is essential to move beyond unrealistic assumptions about disability rights frameworks and to work towards truly localized and transformative efforts.
Abdullah Avlonius in Works The Issue of Promoting Goodwill
Authors: Madaliyev Yarmukhammat Khudaibergenovich
Published: November 2023

In the second half of the 19th century, at the beginning of the 20th century, in the Turkestan district (Central Asia), the merits of the advanced intelligentsia in the development of pedagogical ideas and increasing the work of public education were great. At the same time, there are many merits of a major representative of Jadid literature of the poet, playwright, teacher Abdullah Avloni (1878-1934). He opened schools, and also personally taught, made a great contribution to the work of equipping schools with textbooks. His works "Turkic Gulistan or Morality," "First Teacher," "Second Teacher" "Gulistoni School" have been repeatedly published. Here the work "Turkic Gulistan or ethics" is a vivid example of Uzbek classical pedagogy. Abdullah Avloni, one of the outstanding representatives of Uzbek national culture of the late XIX century of the beginning of the XX century, as a poet, playwright, journalist, scientist, statesman and public figure, a deeper contribution to the development of Uzbek literature, the study of the writer's works.
Market Share and Purchase Influencing Factors of Various Pesticide Brands in Uttar Pradesh
Authors: Arun Kumar Rai  , Kushagra Kulshrestha
Published: November 2023

The worldwide consumption of pesticides is about two million tons per year. Out of which 45 percent is used by Europe alone, 25 percent is consumed in the USA, and 25 percent in the rest of the world. The three most commonly used pesticides are HCH (only gamma-HCH is allowed), DDT and Malathion, and these account for about 70 percent of the total pesticide consumption. India’s consumption of pesticide is only 3 percent of total world’s consumption of pesticides. Among different classes of pesticide, contribution of insecticide (60 percent) is high followed by fungicide (19percent), herbicide (16percent), Bio-Pesticide (3percent) and others (3percent). It is estimated that 18- 20 percent of total pesticides used in the country are applied on vegetables. The Government of India regulates the production, import, Sales, and use of pesticides through the Insecticides Act, 1968. The market in India is highly dominated by the foreign players. Bayer AG is the largest agrochemical producer in the world. Some of the big names include Yara International ASA, BASF, Bayer Crop Science Limited, Indofil Industries Limited, Makhteshim Agan Industries Ltd, Dow Agro Sciences, Monsanto, Syngenta, Aventis, Agrium etc. This study show the market shares of various brands in which 15.15% share in insecticides was Pexalon of Corteva Agriscience, 14.70% chess of Syngenta,13.16% of coragen(FMC India Pvt. Ltd.) and remaining others. In market share 33.09% Indofill Industries, 18.23% UPL and rest in remaining. The retail trade influence was maximum on the farmers and ranked I followed by influence from company representative ranked II. Farmers meeting, distribution of literature and samples, through participation in fairs and wall painting were moderately influencing factors, which were ranked fourth, sixth, and seventh.
Farmer Interest Groups: Paving Its Path Towards Profitability
Authors: Sweta Sahoo  , Bibudha Parasar  , Raj Kishore Mishra  , Ashish Anand  , Smaranika Mohanty  , Utkal Sahoo
Published: November 2023

The current study entailed to ascertain the role that Farmers' Interest Groups played in knowledge transfer as well as in increasing agricultural production, productivity, and in turn leading to profitability for the farm sector in the Boudh district of Odisha. For the impact assessment, six FIGs from a range of villages in the Boudh district, including Baghiapada, Saleising, and Palijhar, were randomly selected. The results of this study depicted that member of Farmer Interest Groups adopted scientific agricultural practices and goatery technologies at a greater mean rate (80.63 MPS and 79.63 MPS, respectively) than non-members (59.12 MPS and 60.12 MPS). The aggregate differences in the adoption of crop and goatery farming technology between FIG members and non-members were calculated to be 21.5 and 19.5 MPS, respectively. It was also found that the crop and goatery production under FIG produced a higher yield than the agricultural practices now employed by farmers. The members became more active in meetings and the adoption of new and scientific farm and goatery technology after learning about the benefits of the FIGs. In addition to enhancing agriculture and animal production, this will also benefit the socioeconomic conditions of the farming community.
Individual age determination based on computed tomography knee analysis using artificial neural networks and computer vision: Preliminary results
Authors: Zolotenkov Dmitry D. , Trufanov Maksim I. , Solodovnikov Vladimir I.
Published: November 2023

BACKGROUND: Currently, studies have focused on the modernization of existing methods of forensic age assessment (bone and skeletal) through the active use of modern methods of medical imaging (e.g., computed tomography) and artificial intelligence for their analysis. This approach enables the creation of new methods for assessing biological age, which is characterized by increased accuracy and reproducibility.
AIM: To develop and test an algorithm for predicting the biological age of an individual based on computed tomography analysis of the knee joint using artificial neural networks and computer vision.
MATERIALS AND METHODS: This observational retrospective transverse (one time) study analyzed computed tomography scans (334) of the knee joint performed in the Departments of Radiation Diagnostics of the Priorov Central Institute for Trauma and Orthopedics, Vreden National Medical Center for Traumatology and Orthopedics, between 2018 and 2021. The study enrolled persons of both sexes aged 13–45 years. Cases of developmental abnormalities, knee injuries, signs of general connective tissue pathology were excluded. Research methods include the use of intelligent information technologies (a formalized set of mathematical and software solutions).
RESULTS: Based on the experiments conducted, an algorithm for assessing age according to the computed tomography scans of the knee joint has been developed. The main components of the developed system are as follows: a preprocessing module, an intelligent computing core, a data analysis module, a three-dimensional reconstruction module, a property extraction module, and a final age assessment module. The essence of the proposed method is the simultaneous use of artificial neural networks and clearly formalized mathematical procedures for calculating the properties of the epiphyseal line. To obtain the results and conduct primary experimental studies that confirmed the feasibility, correctness, and operability of the method, software using the YOLOv5 neural network was developed. The result of the error matrix analysis after training shows a probability of correct recognition of the order of 80%. Verification of experimental studies was performed on 46 cases. At present, the age estimation error is approximately 1 year for children and adolescents.
CONCLUSIONS: The experimental results have confirmed the adequacy of the age estimates obtained to the actual age of the individual and, consequently, the applicability of the proposed method in forensic medical institutions. The proposed method is currently implemented as a set of software components with subsequent manual integration of automatically calculated data. The plan was to supplement the database of computed tomography images to increase the training sample and the accuracy of age prediction.
Examinations of medical cases conducted in the Bureau of Forensic Medical Examination of the Tambov region
Authors: Bestolchenkov Andrey V. , Kurzin Leonid M.
Published: November 2023

BACKGROUND: Over the past 5 years, the number of commission examinations on improper provision of medical care by the Bureau of Forensic Medical Examination of the Tambov Region has increased. These examinations were performed to identify defects in the provision of medical care and determine their effect on an unfavorable outcome for the patient.
AIM: To analyze and evaluate forensic medical examinations performed at the Tambov Regional Bureau of Forensic Medicine in so-called medical cases.
MATERIALS AND METHODS: To identify medical specialties with the most frequent cases of inadequate medical care, which are the direct cause of unfavorable outcomes, an analysis of examinations was conducted for 2017–2021. The study included examinations performed from both the Tambov region and other regions.
RESULTS: The number of cases of inadequate provision of medical care, for which the examination confirmed a cause-and-effect relationship with an unfavorable outcome, remains approximately at the same level throughout 2017–2021, and the largest number of defects in the provision of medical care were identified in the profile “obstetrics and gynecology.” However, the identified defects in the provision of medical care do not directly correlate with the number of examinations prescribed.
CONCLUSION: The analysis of medical cases showed that the number of examinations in which a direct causal link was established between defects in the provision of medical care and adverse outcomes remained low annually (not more than 9%). The largest number of defects in the provision of medical care was found in the profile “obstetrics and gynecology,” which relates to defects in diagnosis and treatment.