bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Penambatan Molekuler Senyawa Mangiferin dari Mahkota Dewa (Phaleria macrocarpa) terhadap Sap 5 Candida albicans
Authors: Gholam Gusnia Meilin
Published: June 2023

Candida albicans (C. albicans) merupakan mikroorganisme komensal. Namun, C.albicans dapat berubah menjadi sifat patogen apabila disebabkan oleh beberapa faktor, sehingga perlu adanya penemuan senyawa-senyawa yang efektif untuk dapat menghambat C. albicans dengan spesifik pada target tertentu dari C. albicans sendiri. Kami memilih Sap 5 sebagai target dari penambatan, disebabkan erat kaitannya Sap 5 dengan terjadinya invasi jaringan. Tujuan dari penelitian ini adalah memberikan hasil berupa apakah terdapat interaksi yang kuat antara senyawa Mangiferin dengan reseptor Sap 5 C. albicans dengan melihat energi bebas Gibbs, agar nanti dapat dilanjutkan dengan uji In vitro. Metode yang digunakan dalam penelitian ini adalah preparasi reseptor dan ligan, validasi Gridbox, Penambatan dan Visualisasi hasil. Hasil yang diperoleh dari penambatan senyawa Mangiferin dengan reseptor Sap 5 pada energi bebas Gibbs pada ulangan ke satu sebesar -8.6190 Kcal/mol. Namun, hasil yang stabil dalam penambatan senyawa Mangiferin dengan Sap 5 yaitu berada pada nilai -8.6170 Kcal/mol.
Molecular Docking of Secondary Metabolite Compounds of Andrographis Paniculata Plant as Potential Covid-19 Drug Candidate
Authors: Ishak Netty Ino , La Kilo Akram , Halidi Dandi  Saputra , Aman La Ode , La Kilo Jafar , Musa Weny J.A.
Published: June 2023

The aim of this research was to investigate the interaction between secondary metabolite compounds and the Mpro receptor, which was the main protein in Covid-19. Ligand-receptor interactions were studied using the Molecular Docking method. The validation results indicated that the test ligand Andrographolide had a higher affinity value compared to the standard ligand, with a value of -6.6 kcal/mol compared to the standard ligand's -7.5 kcal/mol. Additionally, the compound 14-Acetyl-3,19-isopropylideneandrographolide, 5,4 dihydroxy-7,8,2',3'-tetramethoxyflavone-5-glucoside had an affinity of -7.5 kcal/mol, Andrographidin A had -7.6 kcal/mol, Andrographiside had -7.7 kcal/mol, Skullcapflavone I had 7.7 kcal/mol, 5-Hydroxy-7,8,2'-trimethoxyflavone-5-glucoside had -7.7 kcal/mol, Apigenin had 7.7 kcal/mol, 5-Hydroxy-7,8-dimethoxyflavone-5-glucoside had -7.8 kcal/mol, Neoandrographolide had -7.8 kcal/mol, Andropanoside had -7.9 kcal/mol, Wogonin-5 glucoside had -8.1 kcal/mol, 5,2',3'-Trihydroxy-7,8-dimethoxyflavone-3'-glucoside had -8.4 kcal/mol, and Bisandrographolide had -8.5 kcal/mol. From the molecular docking results, the secondary metabolite compounds from the Andrographis paniculata plant exhibited significant interactions surpassing the standard ligand N3. Active residue interactions observed included Phe140, Leu141, Asn142, Gly143, His163, Glu166, Gln189, and Thr190.
FATORES DE RISCO PARA DOENÇAS CARDIOVASCULARES EM USUÁRIOS DE UNIDADES BÁSICAS DE SAÚDE
Authors: Diniz Júnior Alexandre Cavalcante , De Lucena Hannah Karolyne Vieira , Delmiro Andrezza Rayana da Costa Alves , De Queiroz Viviane Cordeiro , De Medeiros Rebeca Cordeiro , Costa Maria Bernadete de Souza
Published: June 2023

Objetivo: Analisar os fatores de risco para doenças cardiovasculares de usuários de unidades básicas de saúde. Método: Trata-se de uma estudo descritivo, transversal, com abordagem quantitativa. A amostra foi definida a partir do número de usuários cadastrados em duas unidades básicas de saúde no município de João Pessoa-PB. Participaram da pesquisa 180 usuários. Resultados:  Destaca-se que 60% eram mulheres. Referente à idade, 64,4% tinham entre 30 e 59 anos. 42,8% cursaram o ensino médio e 32,2% ensino superior, evidenciando um grau de escolaridade satisfatório. Ilustra-se a prevalência de fatores de riscos para doenças cardiovasculares nas variáveis nível de estresse, índice de massa corporal (sobrepeso e obesidade), ausência de atividade física, alimentação não saudável e hereditariedade. Conclusão: Espera-se que os profissionais das unidades básicas de saúde reforcem as orientações para a prevenção de fatores de risco e implementem atividades educativas a fim de orientar hábitos saudáveis para minimizar riscos.
SEGURANÇA DO PACIENTE NA HEMODIÁLISE: UMA PERSPECTIVA SOCIODEMOGRÁFICA, LABORATORIAL E FARMACOLÓGICA
Authors: Mikos Amanda Merloto , Fernandes Natália dos Reis , Spigolon Dandara Novakowski , Labegalini Célia Maria Gomes , Da Silva Vinícius Luís , Lourenço Mariana Pissioli , De Souza Verusca Soares , Christinelli Heloá Costa Borim
Published: June 2023

O objetivo deste estudo é analisar as características sociodemográficas, laboratoriais e farmacológicas de indivíduos que sofreram complicações e eventos adversos durante a hemodiálise. Trata-se de estudo descritivo, transversal e documental. Realizado em uma clínica de terapia renal substitutiva de uma regional de saúde do noroeste do Paraná. A população foi composta de 151 portadores de doença renal crônica em estágio 5 hemodialítico e seus respectivos prontuários, e que faziam tratamento financiado pelo Sistema Único de Saúde. A coleta de dados ocorreu por meio de um questionário semiestruturado nos meses de junho e julho de 2019. A análise dos dados foi por meio de estatística descritiva. Entre os resultados, evidenciou-se que dos 151 participantes, todos tiveram alguma complicação/eventos durante a hemodiálise.  Destacaram-se o sexo masculino (61%), idosos (46,4%), residentes no Noroeste do Paraná (46%), trabalhador rural (23%), pardos (46,4%) e renda de até dois salários mínimos (53%). Foram identificados dados de 37 tipos de exames nos prontuários, com predominância (100%) de ureia, hemoglobina e hematócrito. 44 participantes relataram uso regular de medicação, os medicamentos mais utilizados são a eritropoietina humana recombinante (89%), anti-hipertensivos (70%), sacrato de hidróxido férrico (68%) e cloridrato de sevelâmer (n=98; 65%). Conclui-se que as características que contemplaram o estudo permitiu a identificação ampliada de complicações e eventos que comprometem a segurança do paciente. Assim, destaca-se a importância de compreender os fatores de risco e planejar ações para a melhoria do cuidado.
Final Efficacy and Cost Analysis of a Fish Skin Graft vs Standard of Care in the Management of Chronic Diabetic Foot Ulcers: A Prospective, Multicenter, Randomized Controlled Clinical Trial
Authors: Lantis John , Lullove Eric , Liden Brock , McEneaney Patrick , Raphael Allen , Klein Robert , Winters Christopher , Huynh Ruby
Published: June 2023

Introduction. DFUs remain a cause of significant morbidity. Objective. This is the third of 3 planned articles reporting on a prospective, multicenter, randomized controlled trial evaluating the use of omega-3–rich acellular FSG compared with CAT in the management of DFUs. Materials and Methods. A total of 102 patients with a DFU (n = 51 FSG, n = 51 CAT) participated in the trial as ITT candidates, with 77 of those patients included in the PP analysis (n = 43 FSG, n = 34 CAT). Six months after treatment, patients with healed ulcers were followed up for ulcer recurrence. A cost analysis model was applied in both treatment groups. Results. The proportion of closed wounds at 12 weeks was compared, as were the secondary outcomes of healing rate and mean PAR. Diabetic foot wounds treated with FSG were significantly more likely to achieve closure than those managed with CAT (ITT: 56.9% vs 31.4%; P =.0163). The mean PAR at 12 weeks was 86.3% for FSG vs 64.0% for CAT (P =.0282). Conclusions. Treatment of DFUs with FSG resulted in significantly more wounds healed and an annualized cost savings of $2818 compared with CAT.
ASSESSMENT OF PATIENTS READINESS FOR WEANING FROM THE RESPIRATOR AFTER MECHANICAL LUNG VENTILATION
Authors: CHERNIAIEV S. , DUBROV S.
Published: June 2023

Introduction. Approximately 20% of patients on mechanical lung ventilation (MLA) experience weaning difficulties. It is recommended to evaluate objective clinical criteria used to predict a patient's readiness of weaning from a respirator. Randomized trials have shown the effectiveness and safety of the spontaneous breathing test (SBT) with inspiratory pressure support as a weaning method. Currently, there are many predictors of ventilator weaning, including both clinical and sonographic criteria, such as rapid shallow breathing index (RSBI), diaphragm thickening fraction (DTf), and Diaphragmatic excursion (DE).

Case description. Patient K., 87 years old, has a history of 3 acute ischemic strokes with signs of vascular dementia according to relatives. 3 weeks ago, she hit her head at home and lost consciousness. She was hospitalized in a medical institution, after drainage of subdural hematomas, she was under analgosedation. 26 hours after tracheal intubation, in the presence of clinical criteria, a SBT was performed with calculation of RSBI, DTf and DE. After evaluating the predictors of weaning from the respirator, a decision was made to extubate the patient. After weaning from the respirator, the general condition is satisfactory.

Conclusions. Assessment of predictors of successful ventilator weaning is relevant in elderly patients with dementia, when assessment of mental status is difficult and the use of objective indicators helps in decision-making regarding ventilator weaning.
Assessing the validity of NMR relaxation rates obtained from coarse-grained simulations of PEG-water mixtures
Authors: Gravelle Simon , Beyer David , Brito Mariano , Schlaich Alexander , Holm Christian
Published: June 2023

NMR relaxometry is a powerful and well-established experimental approach to characterize dynamic processes in soft matter systems. All-atom (AA) resolved simulations are typically employed to gain further microscopic insights while reproducing the relaxation rates R1. However, such approaches are limited to time and length-scales that hinder modeling of systems like long polymer chains or hydrogels. Coarse-graining (CG) can overcome this barrier at the cost of loosing atomistic details that impede the calculation of NMR relaxation rates. Here, we address this issue by systematic characterization of dipolar relaxation rates R1 while performing systematic measurements on a PEG-H2O mixture at two different levels of details: AA and CG. Remarkably, we show that NMR relaxation rates R1 obtained at the CG level obey the same trends when compared to AA calculations, but with a systematic offset. This offset is due to, on the one hand, the lack of an intra-monomer component and, on the other hand, the inexact positioning of the spin carriers. We show that the offset can be corrected for quantitatively by reconstructing a posteriori the atomistic details for the CG trajectories.
Effects of Surfactant Adsorption on the Wettability and Friction of Biomimetic Surfaces
Authors: Weiand Erik , Rodriguez-Ropero Francisco , Roiter Yuri , König Peter H. , Angioletti-Uberti Stefano , Dini Daniele , Ewen James P.
Published: June 2023

The properties of solid-liquid interfaces can be markedly altered by surfactant adsorption. Here, we use molecular dynamics simulations to study the adsorption of ionic surfactants at the interface between water and heterogeneous solid surfaces with randomly arranged hydrophilic and hydrophobic regions, which mimic the surface properties of human hair. We use the coarse-grained MARTINI model to describe both the hair surfaces and surfactant solutions. We consider negatively-charged virgin and bleached hair surface models with different grafting densities of neutral octadecyl and anionic sulfonate groups. The adsorption of cationic cetrimonium bromide (CTAB) and anionic sodium dodecyl sulfate (SDS) surfactants from water are studied above the critical micelle concentration. The simulated adsorption isotherms suggest that cationic surfactants adsorb to the surfaces via a two-stage process, initially forming monolayers and then bilayers at high concentrations, which is consistent with previous experiments. Anionic surfactants weakly adsorb via hydrophobic interactions, forming only monolayers on both virgin and medium bleached hair surfaces. We also conduct non-equilibrium molecular dynamics simulations, which show that applying cationic surfactant solutions to bleached hair successfully restores the low friction seen with virgin hair. Friction is controlled by the combined surface coverage of the grafted lipids and the adsorbed CTAB molecules. Treated surfaces containing monolayers and bilayers both show similar friction, since the latter are easily removed by compression and shear. Further wetting MD simulations show that bleached hair treated with CTAB increases the hydrophobicity to similar levels seen for virgin hair. Treated surfaces containing CTAB monolayers with the tailgroups pointing predominantly away from the surface are more hyrophobic than bilayers due to the electrostatic interactions between water molecules and the exposed cationic headgroups.
Fungi Fiction: Analytical Investigation into the Church Of Psilomethoxin's Alleged Novel Compound Using UPLC-HRMS
Authors: Williamson Samuel , Sherwood Alexander
Published: June 2023

The Church of Psilomethoxin claims to produce a novel tryptamine by adding 5-MeO-DMT to the substrate of cultivated Psilocybe mushrooms, which is then biosynthesized into psilomethoxin, the church’s sacrament. In this study, we investigate the validity of this claim using comprehensive analytical techniques, namely ultra-performance liquid chromatography with high-resolution mass spectrometry (UPLC-HRMS). Authentic reference standards for structurally related tryptamines were used for comparison. Our findings revealed no evidence to suggest that the compound psilomethoxin is present in samples of material that the church is offering to their members online. Psilocybin, baeocystin, and psilocin, were, however, unambiguously identified in the sample, suggesting that the claims regarding the biosynthesis of psilomethoxin may be misguided. The implications of these findings should be critically considered within the context of public health and safety
Electron count and ligand composition influence the optical and chiroptical signatures of NIR-emissive DNA-stabilized silver nanoclusters
Authors: Guha Rweetuparna , Gonzàlez-Rosell Anna , Rafik Malak , Arevalos Nery , Katz Benjamin , Copp Stacy
Published: June 2023

Near-infrared (NIR) emissive DNA-stabilized silver nanoclusters (AgN-DNAs) are promising fluorophores in the biological tissue transparency windows. Hundreds of NIR-emissive AgN-DNAs have been recently discovered, but their structure-property relationships remain poorly understood. Here, we investigate 19 different far-red and NIR emissive AgN-DNA species stabilized by 10-base DNA templates, including several well-studied emitters whose compositions and chiroptical properties have never been reported before. The molecular formula of each purified species is determined by high-resolution mass spectrometry and correlated to its optical absorbance, emission, and circular dichroism (CD) spectra. We find that AgN-DNAs emissive at the far red/NIR spectral border are either 6-electron clusters or 8-electron clusters. 8-electron AgN-DNAs are stabilized by two DNA oligomer copies, while three different ligand compositions are observed for 6-electron AgN-DNAs: two oligomer copies, three oligomer copies, or two oligomer copies with additional chlorido ligands. Distinct optical and chiroptical signatures correlate with ligand composition of 6-electron AgN-DNAs. AgN-DNAs with three oligomer ligands exhibit shorter Stokes shifts than AgN-DNAs with two oligomers, and the presence of chlorido ligands is correlated with increased Stokes shifts and significantly suppressed visible CD transitions. Nanocluster electron count also significantly influences electronic structure and optical properties, with 6-electron and 8-electron AgN-DNAs exhibiting distinct absorbance and CD spectral features. This study shows that the optical and chiroptical properties of NIR-emissive AgN-DNAs are highly sensitive to nanocluster composition and illustrates the diversity of structure-property relationships for NIR-emissive AgN-DNAs, which could be harnessed to precisely tune these emitters for bioimaging applications.
VGAE-MCTS: a New Molecular Generative Model combining Variational Graph Auto-Encoder and Monte Carlo Tree Search
Authors: Iwata Hiroaki , Nakai Taichi , Koyama Takuto , Mtsumoto Shigeyuki , Kojima Ryosuke , Okuno Yasushi
Published: June 2023

Molecular generation is crucial for advancing drug discovery, material design, and chemical exploration. It expedites the search for new drug candidates, facilitates tailored material creation, and enhances our understanding of molecular diversity. By employing artificial intelligence techniques, such as molecular generative models based on molecular graphs, researchers have tackled the challenge of efficiently molecules with desired properties. We proposed a new molecular generative model combining deep learning and reinforcement learning evaluated the validity, novelty, and optimized physicochemical properties of the generated molecules. Importantly, the model explored uncharted regions of chemical space, allowing for the efficient discovery and design of new molecules. This innovative approach has significant potential to revolutionize drug discovery, material science, and chemical research for accelerating scientific innovation. By leveraging advanced techniques and exploring previously unexplored chemical spaces, this study offers promising prospects for the efficient discovery and design of new molecules in the field of drug development.
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Authors: A Anandh
Published: June 2023

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Is C-Reactive Protein an Indicator of Periodontal Risk?
Authors: González Gisella Rojas , De la Fuente Sandra Silva
Published: June 2023

Periodontitis is a chronic, multifactorial, inflammatory disease caused by microorganisms and characterized by the progressive destruction of tooth-supporting tissue. In recent years, studies have shown a correlation and association between periodontitis and atherosclerotic cardiovascular disease, because both the disease has some similar risk factors and they produce an increase in plasma C-reactive protein (CRP) level. This protein has been attributed favorable characteristics as an inflammatory marker. This study was aimed to identify if there is any relationship between periodontitis and CRP values before starting periodontal treatment in a group of patients from the Faculty of Dentistry of the University of Costa Rica. Periodontal examinations were performed on 30 patients, and a blood sample was obtained from each patient to determine the P-CR concentration. The average P-CR was found to be 3.72mg/L (95%CI: 2.06–5.38), which is a moderate to severe risk marker. Fifty-four percent of the total patients had chronic generalized periodontal disease, with no significant difference between the different periodontal disease with gender (p=0.416) or age (p=0.477). Meanwhile, forty-three and three percent of the total patients had localized chronic periodontal disease, and gingivitis respectively. It was observed that the female gender showed a relatively higher cardiovascular risk compared to the opposite gender (p=0.640). In contrast, no statistically significant difference was found in the P-CR value by gender, age or the presence of other diseases, although it was higher in those with metabolic diseases (5.5mg/L) compared to those without (2.7mg/L).
Mechanisms of Cognitive Improvement After Carotid Endarterectomy: Results of an Autopsy
Authors: Ogasawara Kuniaki
Published: June 2023

To develop a clinically meaningful definition of cognitive change before and after carotid endarterectomy (CEA), we categorized patients with “improved postoperative function” and “non-improved postoperative function” based on subjective assessment and neuropsychological tests. The results showed that 11% of the patients showed an improvement in postoperative function. Through single-photon emission computerized tomography (SPECT), positron emission tomography (PET), magnetic resonance imaging (MRI), etc., it was found that improvement of cerebral blood flow by carcinoembryonic antigen (CEA) → improvement of cerebral metabolism → improvement of cerebral cortical neuroreceptor function and cerebral white matter microstructure → improvement of cognitive function. The degree of preoperative cerebral hemispheric white matter lesions was the rate-limiting factor for improvement in cognitive function.
Evaluation of Optic Nerve Sheath Diameter Measurement in the Management of Patients Admitted to the Emergency Department with Head Trauma
Authors: Can Özge , Ersel Murat , Yalcinli Sercan , Akarca Funda Karbek
Published: June 2023

Objective: Ultrasonographic measurements of optic nerve sheath diameter is associated with increased intracranial pressure. Intracranial pressure measurements are usually performed on critical areas or intensive care unit patients. The effect of ultrasonographic measurement of optic nerve sheath diameter in predicting pathology or the need for surgery in mild or moderate head trauma has not been evaluated. In our study, we compared ultrasonographic optic nerve sheath diameter measurements with cranial computed tomography (CT) findings and clinical outcomes of patients with head trauma. Materials and methods: Patients with head trauma admitted to the emergency department who were diagnosed with mild, moderate, and severe brain injury were selected for this retrospective study. The optic nerve sheath diameters were measured by ultrasonography. The findings were compared with the outcome and cranial tomography characteristics of the patients. Results: Of the 58 patients admitted to the emergency department with head trauma, mild traumatic brain injury was most common. Hospitalization or operation was required in 51.7% of the patients (30 patients). The mean optic nerve sheath diameter was 4.96 ± 1.02 mm (3.1–7.3 mm) on the right and 4.92 ± 1.02 mm (3.3–7.8) on the left. Optic nerve sheath diameter of 5 mm or more were statistically significant in predicting hospitalization, the presence of pathology, and increased intracranial pressure on cranial CT (P < 0.05). Conclusion: Optic nerve sheath diameters of patients with moderate and mild head trauma may provide information about the need for hospitalization or surgery and can be used as a triage criterion in determining the need for monitoring and follow-up and imaging priorities.
Pelatihan Peningkatan Keterampilan Kader KB Tim Pendamping Keluarga (TPK) dalam Mengatasi Stunting di Kota Tegal
Authors: Damayanti Fitriani Nur , Astuti Rahayu , Istiana Siti , Kusumawati Erna , Janah Aniatul
Published: June 2023

Stunting is included in the priorities of Indonesia's national development. Tegal City is a priority area for handling stunting. Collaboration is needed in assisting families at risk of stunting with various parties, one of which is the PKK cadres so that training is needed for PKK cadres to improve skills for data collection and identification of families at risk of stunting. The purpose of this training activity for family planning cadres is to increase the knowledge and skills of TPK in data collection and identification of the risk of stunting in the city of Tegal. Community service activities training in data collection and identification of families at risk of stunting were attended by family planning cadres in Tegal. After the data collection and identification training activities for family planning cadres the Family Assistance Team (TPK) showed (p = 0.000 <0.05) which means that there was a significant difference in the knowledge of family planning cadres before and after being given training on stunting risk identification and data collection. Stunting can be corrected if it occurs in the first two years of a child's age, but afterwards it will be difficult to correct, so cooperation is needed in stunting prevention. The Family Assistance Team (TPK), one of which is the Family Planning Cadre, is tasked with assisting families at risk of stunting in terms of stunting prevention.
Synthesis, Crystal Structure, Hirshfeld Surface Analysis and DFT Studies of (Z)-1-(2-(4-nitrophenyl)hydrazineylidene)naphthalen-2(1H)-one
Authors: Yıldırım Gümüşhan İ.
Published: June 2023

A new Schiff base compound, (Z)-1-(2-(4-nitrophenyl)hydrazineylidene)naphthalen-2(1H)-one, was prepared and structurally characterized by single-crystal X-ray diffraction. The compound crystallizes in the P2/n monoclinic space group with a = 15.9421(6) Å, b = 7.7607(3) Å, c = 21.8052(9) Å, and β = 92.946(3)°. The molecular geometry of the compound was optimized using density functional theory calculation at HSEH1PBE/cc-pvdz level. Hirshfeld surface analyses for the compound were presented and discussed. The computational findings show that theoretical geometric parameters are consistent with experimental ones. The calculated and experimental results show the title compound tends to the hydrazone (NH) form. Stabilization of the crystal structure was achieved by means of intramolecular N─H···O and intermolecular C─H···O interactions.
КОМПЛЕКСЫ С ПЕРЕНОСОМ ЗАРЯДА ПРОИЗВОДНЫХ 9H-ФЛУОРЕН-9-ОНА С 9-МЕТИЛ-9H-КАРБАЗОЛОМ: КВАНТОВО-ХИМИЧЕСКОЕ МОДЕЛИРОВАНИЕ, РЕНТГЕНОСТРУКТУРНОЕ ИССЛЕДОВАНИЕ
Authors: Линко Р.В. , Рябов М.А. , Давыдов В.В. , Хрусталёв В.Н.
Published: June 2023

На основании квантово-химических расчетов методом DFT получены данные о строении и свойствах комплексов с переносом заряда производных 9H-флуорен-9-она с 9-метил-9H-карбазолом. Рассчитаны энергии образования комплексов, средние расстояния между плоскостями донора и акцептора, величины переноса заряда с донора на акцептор. Методом рентгеноструктурного анализа определена кристаллическая и молекулярная структура комплекса 2,4,7-тринитро-9H-флуорен-9-она с 9-метил-9H-карбазолом (C13H5N3O7∙C13H11N). В кристалле комплекса молекулы донора и акцептора образуют стопки смешанного типа {-D-A-D-A-}¥, где среднее значение межплоскостных расстояний D⋅⋅⋅A составляет 3.30 Å.
СЖИМАЕМОСТЬ АМИДА НАТРИЯ И ВЛИЯНИЕ ДАВЛЕНИЯ НА ЕГО ЭЛЕКТРОННЫЕ СВОЙСТВА
Authors: Корабельников Д.В. , Федоров И.А. , Кравченко Н.Г. , Корабельникова Е.Ю.
Published: June 2023

С помощью первопринципных расчетов, основанных на теории функционала плотности, исследовано влияние давления на структуру и электронные свойства α-фазы амида натрия. Вычислены линейные сжимаемости α-NaNH2 и выявлена отрицательная линейная сжимаемость (- 12 ТПа-1), вызванная увеличением угла ∠(N⎯Na⎯N) с ростом давления. На основе квантово-топологического анализа электронной плотности изучены межатомные взаимодействия. Методом гибридного функционала рассчитаны изменения ширин зон α-NaNH2 под давлением.
Sufficient Conditions for Convergence of Sequences of Henstock-Kurzweil Integrable Functions
Authors: Alzubaidi Yassin
Published: June 2023

The main aim of this paper is to present our approach of obtaining sufficient conditions for convergence of sequences of Henstock-Kurzweil integrable functions. Our approach involves the use of the concept of multiplier functions, where we define a class Φ of multipliers for the Henstock-Kurzweil integral. We consider a sequence (fn) of Henstock-Kurzweil integrable functions on a non-degenerate interval [a, b] and we assume that (fn) converges point wise to a function f. Then we show that f is Henstock-Kurzweil integrable and its integral is equal to the limit of the sequence (∫abfn) if there exists φ∈Φ such that the defined functionals of the type F (φ, fn) satisfy the imposed conditions. Beside the fact that the results regarding the convergence under the integral sign are always of great importance, the method introduced here can be imitated and used to obtain other results on the related areas.
PHYSICAL ACTIVITY AS THE MAIN PRIORITY FOR THE DEVELOPMENT OF A SUCCESSFUL COUNTRY: EUROPEAN EXPERIENCE
Authors: Anastasiia Starchenko
Published: June 2023

Introduction. One of the leading tasks of the public health system is to increase the life expectancy of people of active and working age, as well as to promote a healthy lifestyle through the combined efforts of the whole society. It should be noted that the leading role refers specifically to physical activity, which affects different aspects of the personality and is of great economic and practical importance for the country. An analysis of documents, recommendations and measures to attract different groups of the population of European countries to an active lifestyle showed that this issue is very acute and relevant especially at the state, economic and political levels. Aim is to analyze the model of increasing the level of physical activity of the population of European countries with the aim of its further application in Ukraine. Material and methods: analysis and generalization of scientific and methodological literature, comparison. Results: the model of physical activity of the population of European countries according to the GAPPA ((Global Action Plan on Physical Activity) recommendations was analyzed. To achieve the goals set, it is necessary to work in four strategic policy areas: active societies, active environments, active people and active systems. Conclusions: for all EU countries, it is recommended to strengthen control over the problem of optimizing the physical activity of the population at all levels of the state; to increase the role of knowledge about the cross-cutting contribution of physical activity to national development and many global priorities, and to ensure accountability for the implementation of specific policy actions. A well-executed physical activity model across all European countries could reduce physical inactivity by 15% by 2030 and therefore it can be useful for use in Ukraine.
Sentiment Analysis on Social Media with Glove Using Combination CNN and RoBERTa
Authors: Diaz Tiyasya Putra  , Erwin Budi Setiawan
Published: June 2023

Twitter is a popular social media platform that allows users to share short message’s opinion and engage in real-time conversations on a wide range of topics known as tweet. However, tweets often have a complicated and unclear context, which makes it difficult to determine the actual emotion. Therefore, sentiment analysis is required to see the tendency of an opinion, whether the opinion tends to be positive, negative, or neutral. Researchers or institutions can find out how the response and emotions of an issue are happening and make good decisions. With the large user of Twitter social media in Indonesia, sentiment analysis will be carried out using deep learning Convolutional Neural Network (CNN), Term Frequency-Inverse Document Frequency (TF-IDF), Robustly Optimized BERT Pretraining Approach (RoBERTa), Synthetic Minority Over-sampling Technique (SMOTE), and Global Vector (Glove). In this research, the dataset used is trending topics with hashtags related to government policies on Twitter social media and obtained through crawling. By using 30.811 data, the result shows the highest accuracy of 95.56% using CNN with a split ratio of 90:10, baseline unigram, RoBERTa, SMOTE, and Top10 corpus tweet with an increase 10.1%.
APLIKASI PUPUK KOMPOS LIMBAH ORGANIK DAN PUPUK N,P,K TERHADAP RESPON TANAMAN KACANG TANAH
Authors: Nurcahya Intan
Published: June 2023

Penelitian ini bertujuan untuk mendapatkan dosis pupuk kompos limbah organik dan pupuk N,P,K yang lebih baik terhadap respon tanaman kacang tanah. Metode penelitian menggunakan Rancangan Acak Kelompok dengan 10 perlakuan dan 3 ulangan. Perlakuan A : 100 % Pupuk N,P,K; B : Pupuk Kompos Limbah Organik 2 ton/ha; C : Pupuk Kompos Limbah Organik 4 ton/ha; D : Pupuk Kompos Limbah Organik 6 ton/ha; E : Pupuk Kompos Limbah Organik 2 ton/ha + 75 % Pupuk N,P,K; F : Pupuk Kompos Limbah Organik 2 ton/ha + 50 % Pupuk N,P,K; G : Pupuk Kompos Limbah Organik 4 ton/ha + 75 % Pupuk N,P,K; H : Pupuk Kompos Limbah Organik 4 ton/ha + 50 % Pupuk N,P,K; I : Pupuk Kompos Limbah Organik 6 ton/ha + 75 % Pupuk N,P,K; J : Pupuk Kompos Limbah Organik 6 ton/ha + 50 % Pupuk N,P,K. Hasil penelitian menunjukkan pengaruh yang tidak berbeda namun terdapat perlakuan yang lebih baik. Pemberian 100 % Pupuk N,P,K; Pupuk Kompos Limbah Organik 2 ton/ha + 75 % Pupuk N,P,K dan Pupuk Kompos Limbah Organik 6 ton/ha + 50 % Pupuk N,P,K menunjukkan hasil yang lebih baik terhadap jumlah polong isi per tanaman, jumlah biji per tanaman, bobot 100 biji, bobot biji per tanaman, bobot polong isi per tanaman, dan bobot biji per petak dibandingkan dengan pemberian Pupuk Kompos Limbah Organik 2 ton/ha.
Development of Contextual Physics Teaching Materials Assisted by Virtual Lab Based-Android as Alternative Learning in Covid-19 Pandemic
Authors: Rahmatullah Rahmatullah , Bahtiar Bahtiar , Maimun Maimun
Published: June 2023

This study aims to develop effective and efficient contextual physics teaching materials for students and teachers in the Covid-19 pandemic. The teaching materials are based on virtual lab-based Android so that they can be used in any conditions, including when applying physical distancing protocols at school or study from home (SFH). The teaching materials in the form of this application makes it easy for students to access the content on their mobile phones even when they cannot connect to the internet. Also, this application is very easy for teachers to be used. The research method used is based on the 4D model, that is define, design, develop and disseminate. The teaching materials that have been developed passed the first stage test with a Very Good result. The validity test is assessed by expert validators. The subject material used in this study is limited to Reflection and Refraction of Light. The response of students using the teaching materials is Good. According to the students, the teaching materials are easy to use, motivate learning, and deem effective in its implementation
Modeling Viral Evolution and Epidemic Simulation Using Genetic Algorithms
Authors:   Korean Science Education Society for the Gifted, Paek Junghyun , Yoo Hagun , Kyung Dain
Published: June 2023

In this study, Genetic Algorithm was introduced to simulate virus mutation and to understand the changes in viral traits and human immunity. In the simulation, humans move randomly and social distancing measures are implemented when the number of infected humans exceeds 5%. The virus is defined by two traits: the infection rate between humans and the virus attack, represented by strings and floating-point genes, respectively. The progression of the disease is calculated through the “life system” based on the competition between the virus attack and the human recovery rate. The viruses were classified into subspecies based on genetic similarity. Through analysis of the changes in traits per species, it was concluded that an increase in infection rate and a decrease in virus attack within the body were favorable variations for the survival of the virus. Simulation results were compared with the daily new confirmed COVID-19 cases in Sweden, demonstrating accuracy of the simulation. This simulation is more realistic and adaptable in terms of the implementation of mutations and immunity compared to existing spread models. It is expected that by analyzing the effectiveness of quarantine policies, the damage caused by infectious diseases could be reduced drastically.
Kit for Optical Isomer Testing and Synthesis
Authors:   Korean Science Education Society for the Gifted, Cho Won-Jae , Kang Min-Ji , Kim Seung-Ahn , Kim Tae-eun , Jang Seo-Young , Cho Eun-Hye
Published: June 2023

On this study, we produced an educational experimental kit for classifying reagents by manufacturing a simplified polarimeter. Actual polarimeters are generally less accessible for using. Thus, we used polarizers and acrylics to produce an educational experimental kit. In this study, we measured the photoactivity of reagents, and the error range was less than ±1°. Additionally, we automated the process of measuring photoactivity by using arduino. It is expected that this kit can be used as an experimental tool to predict results in advance before using an actual polarimeter in the future.
To assess the frequency of antibiotic use through internet and social media among people visiting Rawal Institute of Health Sciences.
Authors: Asma Abdul Qadeer  , Rabia Mahmood  , Saadia Baran  , Sara Bashir Kant  , Nida Badar  , Bushra Liaqat
Published: June 2023

Objective: To assess the frequency of antibiotic use through internet and social media among the people visiting Rawal institute of health sciences. To assess knowledge about antibiotics and to explore role of internet search engines and social media for accessing information regarding antibiotic use. Study Design: Cross-sectional Descriptive study. Setting: Rawal Institute of health sciences, Islamabad, Pakistan. Period: June 2019 to September 2019. Material & Methods: A was study carried to find out the role of internet and social media for use of antibiotics through a structured questionnaire from 150 people visiting RIHS. Sampling was done through non probability convenient sampling method. Response rate was 100%. Results: The data of 150 participants showed 92% have used antibiotics in their life time, of those 92% (n=138) participants, 26 %( n=39) have used them through prescription, 30% (n=45) have done self-medication, 19% (n=29) have used social media for medication. 91% think that information regarding use of antibiotics can be spread through internet and social media. Conclusion: The results conclude that social media and internet related antibiotic sales is contributing a substantial share. Majority of the participant also think that internet and social media are the best source to spread information for safe use. National guidelines should be devised for appropriate information seeking and communication interventions can be done using internet and social media.
Frequency of two canals in mandibular central incisors in Karachi Pakistan: An in-vitro study.
Authors: Sana Syed  , Sheikh Haroon Shah  , Fariha Irfan  , Hina Hammad  , Abdur Rehman  , Syed Abrar Ali
Published: June 2023

Objective: To determine the frequency of two canals in mandibular central incisors using a radiographic technique in a sample representing Karachi Pakistan. Study Design: Cross-sectional in Vitro study. Setting: Hamdard University Dental Hospital. Period: January, 2022 to July, 2022. Material & Methods: According to inclusion criteria 187 extracted mandibular central incisors were collected, flushed under running tap water. 10% formalin was used as storage media afterwards. The attached periodontal tissues and calculus remaining after extraction were removed using a 1/2 Gracey Curette. Number 2 round bur was used in a high speed hand piece to initiate access chamber opening of the pulp chamber. Irrigation was done with 2.5% sodium hypochlorite to make the pulp chamber clearly visible. Detection and negotiation of second canal were performed by using Dental Operating Microscope. No. 15 K-files were introduced into the main canals. Two peri-apical radiographs were exposed at different angulations using DIGORA OPTIME for confirmation. Data was analyzed by using SPSS version 23. Results: Mean age of the patients included in the study were 37.12±12.81 years. According to gender distribution there were 101 (54%) males and 86 (46%) females. Outcome concludes that in mandibular central incisors frequency of two canals was 28.3 %. Conclusion: Presence of two canals in mandibular central incisors among Pakistani population in our study was 28.3%. When endodontic therapy is commenced on these teeth, dentist must consider the possibility of existence of second canal and exercise caution.
Congenital cardiac malformations in children with down syndrome: An echocardiographic based study.
Authors: Hussain Bux Korejo  , Sadaf Liaqat  , Sohaib Riaz  , Veena Kumari  , Khurram Shahnawaz  , Farhan Zahoor  , Fazal ur Rehman
Published: June 2023

Objective: To find out the prevalence and pattern of congenital heart diseases (CHDs) in children with Down syndrome (DS). Study Design: Cross-sectional study. Setting: Department of Pediatrics, Rai Medical College Teaching Hospital, Sargodha, Pakistan. Period: January 2021 to December 2022. Material & Methods: A total of 165 children of either gender, aged 1 month to 12 years with DS diagnosed with the help of typical clinical features and confirmation by cytogenetic studies were analyzed. Children diagnosed with DS were further evaluated for cardiac assessment as per 2-D echocardiographic and Doppler examinations. The prevalence of CHDs was noted among children with DS. Results: In a total of 165 children with DS, 86 (52.1%) were male. The mean age was noted to be 1.8±1.2 years while 106 (64.2%) children were aged below 1 year. The existence of CHDs was found to be in 56 (33.9%). Among 56 children with CHDs, ventricular septal defect (VSD), atrial septal defect (ASD) and tetralogy of fallot (TOF) were the commonest forms of CHDs noted in 16 (28.6%), 12 (21.4%) and 9 (16.1%) children respectively. Conclusion: High prevalence of CHDs in children with Down syndrome was noted. The VSD and ASD were the most common forms of CHDs among children with Down syndrome.
Intolerância do Glúten, ingredientes e processo de panificação
Authors: Silva Juliana Dara Rabêlo , Rosa Guilherme Caldeira , Neves Nathália de Andrade , Schmiele Marcio
Published: June 2023

Esse livro traz uma revisão bibliográfica sobre a intolerância ao glúten e opções para a panificação gluten free, com ingredientes potencialmente interessantes para a panificação.
A IMPORTÂNCIA DO EXERCÍCIO FÍSICO DURANTE A GRAVIDEZ
Authors: Gesilane Maria , Nascimento Vitória Karin dos Santos
Published: June 2023

É evidente a importância do exercício físico durante o período gestacional, no qual numerosos benefícios são proporcionados a saúde da gestante antes e após gravidez, evitando, portanto diversos desconfortos durante esse processo. Por meio de um estudo de caráter exploratório, foi feita uma breve revisão em vários bancos de dados, como Scielo, (BVS) Biblioteca Virtual em Saúde, Pubmed, procurando identificar estudos que corroboram a eficácia do exercício físico durante o período gestacional. Diversos estudos apontaram a importância do exercício na saúde da gestante e do feto, em virtude à minimização dos desconfortos proporcionados pelas alterações fisiológicas e físicas, dentre esses desconfortos estão às alterações funcionais devido ao aumento de peso da gestante. Vale lembrar que tem determinados exercícios que são adequados nesse período e deve-se atentar a cuidados e indicações a ser seguidas pelas gestantes para que não lese o desenvolvimento do feto. Assim, a prática de exercício físico precisa ser orientada por um profissional de educação física após liberação do médico especialista. Este estudo procurou mostrar a importância da prática de exercícios físicos bem como seus benefícios à grávida e ao feto. Pode-se concluir que o exercício físico é de suma importância nesse período desde a concepção ao nascimento minimizando assim aqueles desconfortos em que a gravidez favorece devido às alterações fisiológicas e físicas. Múltiplos são os benefícios a saúde da grávida no pré e no pós-parto, onde a recuperação ocorre de forma mais breve.
Particularities of COVID-19 infection in chronic hemodialysis patients in Sub-Saharan Africa: experience from Senegal (West Africa)
Authors: Kane Yaya , BA Mamadou AW , Lemrabott A Tall , Mah Sidi Mohamed , Koulibaly CA Tidiane , Ndiaye Fatou , Gaye Mactar Amadou , Faye Maria , Faye Moustapha , Seck S Mohamed , KA El Fary , Niang Abdou , Diouf Boucar
Published: June 2023

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appeared in December 2019 in China and has rapidly become a major global health concern. Patients with end-stage renal disease receiving dialysis treatment are very exposed to the SARS-CoV-2 during their frequent visits to healthcare facilities and immune induced by uremia. The aim of our work was to describe the particularity of COVID-19 infection in hemodialysis patients in sub-Saharan Africa and in Ziguinchor, south of Senegal, particularly. To do this, we conducted a monocentric prospective study over a period of 16 months at the Ziguinchor hemodialysis center and compared our results to a study that focuses on the seroprevalence of SARS-CoV-2 in chronic hemodialysis patients. We found a low prevalence of COVID-19 infection while the majority of our patients were in contact with the virus.
Anais do XXVII Congresso Brasileiro de Física Médica 2023
Authors: Associação Brasileira de Física Médica
Published: June 2023

Resumos aceitos para o XXVII Congresso Brasileiro de Física Médica, realizado pela Associação Brasileira de Física Médica, de 12 a 15 de junho de 2023, em São Pedro-SP.
Fase dan Makna Simbol Ritual Badudus dalam Novel "Lalu Tenggelam di Ujung Matamu": Kajian Antropologi Simbolik Victor Turner
Authors: Azmi Ullul
Published: June 2023

Artikel ini bertujuan untuk menggambarkan fase dan makna simbolis dari Ritual Badudus dalam novel Lalu Tenggelam di Ujung Matamu karya Miranda Seftiana. Badudus adalah ritual bridal shower untuk keturunan kerajaan. Penelitian ini merupakan penelitian deskriptif kualitatif. Teori yang digunakan dalam penelitian ini adalah antropologi simbolik Victor Turner dengan fokus pada penelitian fase dan makna simbolik. Teknik pengumpulan data dari penelitian ini adalah dokumentasi, membaca, dan mencatat. Teknik analisis data yang digunakan adalah teknik analisis isi dan hermeneutik. Hasil penelitian ini menemukan tiga fase dalam prosesi Ritual Badudus, yaitu  fase pemisahan, fase liminal, dan fase reintegrasi. Makna simbolis Ritual Badudus yang terkandung dalam novel Lalu Tenggelam di Ujung Matamu meliputi makna daun pacar, tandan mayang, air doa, kelapa, kain kuning, dan pupur basahKata Kunci: Fase, Makna, Simbol, Badudus, Novel
Partikel Dalam Bahasa Gayo Pada Masyarakat Bebesen
Authors: Harfiandi Harfiandi , Syahrin Alfi
Published: June 2023

Pemakaian partikel dalam bahasa Gayo dihasilkan secara unik dalam percakapan sehari-hari.  Akan tetapi, peran dan fungsi yang melekat dalam penggunaan partikel kadang-kadang tidak disadari oleh penutur. Untuk itu, tujuan penelitian ini mendeskripsikan bentuk, peran, dan fungsi partikel dalam bahasa Gayo pada masyarakat Bebesen. Metode yang digunakan dalam penelitian ini adalah deskriptif kualitatif. Teknik pengumpulan data dilakukan dengan teknik simak bebas libat cakap. Analisis data digunakan dengan padan referensial dan metode agih dengan teknik ekspansi. Hasil yang diperoleh dari analisis data menunjukkan bahwa bentuk-bentuk partikel meliputi di, gə, he, kə, kəta, lə, dan mi. Peran dalam penggunaan partikel memberikan makna tambahan dan penegasan dengan mengacu pada unsur-unsur bahasa Gayo seperti adjektiva, demostrativa, dan kata tanya. Kehadiran penggunaan partikel dalam konteks kalimat bahasa Gayo menandai fungsi emotif ketidaknyamanan, kekaguman, kerasahan, kejutan, keheranan, dan keinginan untuk bertindak.Kata Kunci: Partikel, Bentuk, Peran, Fungsi, Bahasa Gayo.