bluuebunny/crossref_metadata_2025 huggingface dataset:
İbn Şerīf Yādigār adlı eserinde Cerrāḥ Meḥmed’in risalesinden gerçekten yararlandı mı? Yazma eserlerin yayınlanmasıyla ilgili yöntembilgisel bir sorun üzerine
Authors: ACIDUMAN Ahmet , GÜNEŞ Nuray
Published: January 2023

Amaç: Cerrāḥ Meḥmed’in tıbba dair risalesinin İbn Şerīf’in Yādigār’ındaki kaynaklardan biri olarak kullanılıp kullanılmadığının belirlenmesi ve bu bağlamda yazma eserlerin yayınlanması sırasında tenkitli metin hazırlanmasının önemine dikkat çekilmesidir.

Gereç ve Yöntem: Cerrāḥ Meḥmed’in İBB, Atatürk Kitaplığı, OE_Yz_K0827_03’de yer alan tıbba dair risalesi, İbn Şerīf’in Yādigār’ının Merkezefendi Geleneksel Tıp Derneği tarafından yayınlanan matbu nüshası ile Yādigār’ın farklı yazmaları incelenmiştir. Curcānī’nin Yād-gār ve Ḫuffey ʿAlāʾī adlı eserlerinin ilgili bölümleri de gözden geçirilmiştir.

Bulgular: Cerrāḥ Meḥmed’in tıbba dair risalesinin İbn Şerīf’in Yādigār’ının matbu baskısının ilgili bölümünde neredeyse birebir bulunduğu görülürken, Yādigār’ın daha erken dönem nüshalarında ise ilgili bölümün daha kısa ve farklı olduğu ve bu bölümün Curcānī’nin Yād-gār’ı ile Ḫuffey ʿAlāʾī’deki bölümleriyle çok büyük benzerlik gösterdiği, bu bağlamda, Cerrāḥ Meḥmed’in, temelde İbn Şerīf’in Yādigār’ının ve indirekt olarak da Curcanī’nin Yād-gār adlı eserinin ilgili bölümlerinden yararlanmış ve risalesine muhtemelen bir başka kaynaktan/kaynaklardan alıntılamış olduğu bölümü/bölümleri eklemiş olduğunu söylemek olanaklı görünmektedir. Ayrıca İbn Şerīf’in Yādigār’ının farklı müstensihlerce kopyalanırken, ikinci bir versiyonunun ortaya çıktığı ve bu versiyonda Cerrāḥ Meḥmed’in tıbba dair risalesinin de ilgili bölüme eklenmiş olabileceği fark edilmektedir.

Sonuç: İbn Şerīf’in Yādigār’ını hazırlarken, ilgili bölümde Curcānī’nin Yād-gār’ının “Kırık, ezik ve eklemin yerinden çıkması hakkında” başlıklı bölümünü çevirerek eserine aldığı, buna karşın Yādigār’ın Topkapı Revan 1684 nüshasında, İbn Şerīf’in çevirdiği bu bölümün yerine, Cerrāḥ Meḥmed’in İbn Şerīf’in yazdıklarına çeşitli eklemelerle hazırladığı risaleye yer verilmiş olduğu görülmektedir. Bu bulgu da İbn Şerīf’in Yādigār’ının iki farklı versiyonunun olabileceğine işaret etmektedir. Bu nedenle yazma eserin mutlaka farklı nüshalarının göz önüne alınarak tenkitli bir metin hazırlanması ve yayımlanması büyük önem taşımaktadır.
THE EFFECTS OF A SUMMER PROGRAM ON PHYSICAL FITNESS AND HEALTH OUTCOMES IN CHILDREN
Authors: Bonner Joseph A. , Velasquez Carolina , Cruz Natasha , Friedman Alexis , Lee Debbiesu , Perry Arlette C.
Published: January 2023

https://youtu.be/uCkCVkd6kSY

BACKGROUND

High rates of adolescent obesity and its associated co-morbidities have been attributed to a lack of physical activity and unhealthy nutrition habits. This is especially apparent during the summer months, when adolescents are out of school and do not have the structure of the academic year and its planned extracurricular activities. The Translational Health in Nutrition and Kinesiology (THINK) program is a nutrition and exercise science curriculum that is interfaced with social emotional learning (SEL) to enhance to personal health and lifestyle behaviors in middle school youth. The purpose of this study is to determine whether the THINK program could improve physical fitness, nutrition habits, and SEL in a 6-week summer program across a 3 year period.

METHODS/DESIGN

Participants from the South Miami community were enrolled in the THINK (n =108, 58 males, 50 females, 12.03 +.56 years). The assessments of physical fitness included: cardiorespiratory fitness (CRF) using the Pacer test, flexibility using the Sit & Reach test, power using the Vertical Jump test, agility using the Shuttle Run, and muscular endurance using the Curl-up test. Body composition was analyzed using the Inbody 520 and SEL was measured using the Positive Youth Inventory. Food habits were measured using the Adolescent Food Habits Checklist. Means and standard error values were evaluated for all dependent variables. Paired sample t-tests (SPSS version 27) were performed to determine changes in dependent variables over time.

RESULTS

Significant improvements in CFF (p<.001), power (p<.006), flexibility (p<.001), agility (p<.001), muscular endurance (p<.001), lean body mass (p<.001) Food Habits (p<.001), and SEL (p=.038) were found.

CONCLUSION

An integrative and physically active summer program can result in improvements in physical fitness, nutrition habits, and SEL in as little as 6-weeks. The emphasis on physical activities in combination with nutrition, science and SEL in programs such the THINK program may serve as novel approach for improving physical fitness and lifestyle behaviors in middle school adolescents during the summer months. Future studies should include control groups to determine whether these changes occur independent of typical maturation and developmental processes in youth.
THE ROLE OF THE EXERCISE PROFESSIONAL IN THE SUPERVISED VERSUS TELEREHABILITATION EXERCISE PROGRAMS FOR MULTIPLE SCLEROSIS (STEP FOR MS) TRIAL
Authors: Born Kathryn A. , Neal Whitney , Ng Alexander V. , Backus Deborah , Motl Robert W
Published: January 2023

https://youtu.be/itqMuZmn70Q

BACKGROUND

The STEP for MS trial was designed and delivered by a team of medical and rehabilitation professionals with a key player being the exercise professional (EP). Our purpose is to showcase the role of the EP and methods for standardized, safe and effective exercise and behavior change intervention.

DESIGN

Site principal investigators who designed the intervention and implementation plan were physical medicine and rehabilitation doctors, physical therapists and kinesiologists with expertise in MS and exercise programming. The interventional EP were site staff members with varied backgrounds in delivering exercise programming to people with MS. Professional titles include personal trainer, exercise specialist, clinical exercise physiologist, graduate teaching assistant, research associate, clinical integration and research coordinator. Interventionalists had little to no prior experience using the theory-based behavior change strategies employed in the trial.

METHODS

To accommodate differences in EP backgrounds and expertise, standardized training on behavior change principles and exercise prescription was required. Weekly booster meetings were held via Zoom to discuss participant progress, challenges and identify solutions and modifications to the intervention while maintaining trial fidelity. Supporting materials like exercise training manuals, scripts, newsletters, logbooks and calendars were used by EPs to deliver the intervention. EPs deployed their unique skills and training to provide guidance on exercise program progression, exercise technique modification and behavior change strategies to participants. EPs and participants mutually decided on the trajectory of exercise progression based on experiences during the first 2 standardized weeks. The trajectories differed in the rate of progression with all participants meeting the exercise guidelines of 30 minutes of aerobic exercise and 5–10 strength exercises consisting of 1–2 sets, 10–15 repetitions targeting lower body, upper body, and core musculature 2 days a week, by week 10 of the program. Outcome measures were transcribed by EPs in a research database.

CONCLUSION

There was a varied skillset among principal investigators and interventionalists in the STEP for MS trial which provided a well-rounded intervention to people with MS. Standardized training, trial-issued supporting materials and weekly booster meetings enabled successful and standardized program implementation across 8 sites.
Experiment ended
Authors: Robinson Jonny
Published: January 2023

The Impact of Science on Human Health and Ethics: A Review of the Article "U.S. Should Expand Rules for Risky Virus Research to More Pathogens, Panel Says"
Antibiotiques vétérinaires au Vietnam : état des lieux, risques pour la santé publique vétérinaire et recommandations
Authors: Deborde Philippe
Published: January 2023

Le Vietnam est le 3ème pays le plus peuplé de l’Association des Nations des pays de l’Asie du Sud-Est (ASEAN) avec 95,5 M d’habitants et représente la 6ème économie de la région (Site de la Direction Générale du Trésor et de la Banque Mondiale). La politique du Doi Moi («renouveau»), engagée en 1986, a permis au Vietnam d’enclencher d’importantes réformes de modernisation et un envol économique majeur : le pays est alors passé d’une économie planifiée rigide à une économie de marché qui s’ouvre de plus en plus au monde comme le montre la récente signature de l’Accord de Libre Echange (ALE) avec l’Union Européenne.
The Benefits & Challenges Of Open Access Publishing
Authors: Han YouAI
Published: January 2023

The Benefits & Challenges Of Open Access Publishing
The Impact of Science on Society: The Need for Ethical Regulation
Authors: Han YouAI
Published: January 2023

The Impact of Science on Society: The Need for Ethical Regulation
The Cost of Science Asian Researchers and the Disparity in US Funding
Authors: Han YouAI
Published: January 2023

The Cost of Science Asian Researchers and the Disparity in US Funding
Experiment ended
Authors: Robinson Jonny
Published: January 2023

The Use of Open-Access Policies to Reduce the Cost and Improve the Ethics of Science
The Banker Inspirasi Wirausaha Perbankan
Authors: Asshiddik Faqih
Published: January 2023

Cerita ini dimulai tahun 1939 ketika Bernard Garrett masih seorang anak kecil yang membersihkan sepatu, keinginan Bernard Garrett yang ingin belajar dan keingin-tauan yang sangat besar, dimulai dengan mendengarkan klien-klien yang berbicara tentang bisnis atau orang-orang disekitarnya, Bernard mulai belajar sedikit demi sedikit. Bernard selalu memiliki ketertarikan dengan Real Estate, melihat peluang yang besar terlepas darilingkungan yang sangat diskriminatif di Los Angeles, Bernard berpidah dari Texas di tahun 1954. Di LA Bernard bertemu dengan Joe Morris, seorang pengusaha with deep pockets dan sebuah klub the Plantation Club. Bernard menjelaskan rencananya mengenai membeli, merenovasi dan menyewa rumah di white areas untuk black middle class yang semakin bertumbuh di kota.
The Impact of Science Funding Disparities on Asian Researchers
Authors: Han YouAI
Published: January 2023

The Impact of Science Funding Disparities on Asian Researchers
Ikhtisar Belajar Penciptaan Bisnis Baru
Authors: Asshiddik Faqih
Published: January 2023

Hal yang paling mendasar dalam membangun bisnis adalah membuat business model terlebih dahulu, hal ini ditujukan untuk memudahkan seorang entrepreneur agar bisnis mereka memiliki dasar yang kuat, goals yang ingin dituju, agar business tersebut tidak kehilangan arah ditengah jalan, business model juga ditujukan untuk menjawabpertanyaan seperti
E-Government and Budget Transparency of Indragiri Hulu Government
Authors: afandi syed agung , afandi muslim
Published: January 2023

Information and Communications Technology (ICT) become an essential requirement in developing information society and a knowledge society. Indragiri Hulu Regency is the only regency in Indonesia to be piloting an Open Government Indonesia (OGI) project with the targets to maximize the use of the website for the needs of alternative information media. Based on the assessment of the Indonesian Forum for Budget Transparency (FITRA) in 2013 Indragiri Hulu Regency scored 23 below the maximum score of 100. This study aims to determine the budget transparency of Indragiri Hulu Regency government through its official website. This study uses a qualitative method. The findings of this study indicate that the Indragiri Hulu Regency government has an official website and accessible, but the website does not encounter any special content of budget transparency. As for the publication of budget documents to be done but in different content. Furthermore, Indragiri Hulu Regency also government budget documents does not update regularly on its official website. This is due to the absence of awareness of local government and the absence of strict sanctions so that people has not be Able to access information on the implementation process of local budget policy.
Assessment of Oral Cancer: A Study in Nepal Cancer Hospital and Research Center, Harisiddhi, Lalitpur, Nepal.
Authors: Thapa Kapil , Jaiswal Puja
Published: January 2023

Oral cancer is becoming very common and increasing day by day in Nepal. It ranks 6th in the world and 5th in Nepal among all types of cancer as of 2018.  This is a hospital-based retrospective study. Required details of 128 patients who underwent surgery from 1st April 2018 to 30th October 2019 in Nepal Cancer Hospital and Research Center, Lalitpur. Data were collected age-wise, sex-wise, site-wise, and stage-wise prevalence was figured out. The data were analyzed using MS excel 2007. It was found that males were more commonly affected than females with the mean age for males at diagnosis being 53.3 years and females being 55.62 years. The tongue was the most affected site followed by GBS then buccal mucosa and RMT. Most people knew about cancer growing on them only at advanced stages.
Priority actions for elevating liver health in Canada: A call to action
Authors: Brahmania Mayur , Biondi Mia J , Joshi Supriya , Lee Elizabeth , Jung Hsiao-Ming , Kehar Mohit
Published: January 2023

Chronic liver disease (CLD) has become a silent epidemic in our country and has resulted in significant physical, psychosocial, and financial burden. Although other international liver associations have published frameworks for the principal actions required to improve liver health across health systems, Canada does not have a strategy to address the growing concerns of CLD. Thus, a multidisciplinary group of care providers involved in CLD management in Canada gathered to review the current burden of disease, gaps in management, and key opportunities for improving the identification and management of people at risk of developing progressive CLD.
Invisibility while under Scrutiny: Media Portrayals of White Temporary Foreign Workers
Authors: Hari Amrita , Ahmed Saher
Published: January 2023

Background: Temporary foreign workers (TFWs) in Canada became the focus of public and media scrutiny in 2013 for allegedly replacing Canadian workers. One group of workers escaped the same scrutiny despite working in similar occupational categories—International Experience Canada (IEC) participants, primarily white, young workers from a variety of European countries, Australia, and New Zealand.

Analysis: This article explores the significance of the spectre of whiteness to contemporary Canadian migration governance and employs critical discourse analysis, paying attention to the tone of select front-page coverage of the IEC program in two Canadian and two Irish news outlets.

Conclusions and implications: The limited coverage of ethnically white IEC participants shielded them from the negative scrutiny experienced by racialized TFWs. “Irish” became a stand-in for the infinite variability of whiteness in Canadian nationhood.
Засоби здійснення моніторингу якості освіти вчителем початкової школи
Authors: Митник Олександр
Published: January 2023

Анотація. Аналіз наукової літератури свідчить, що бракує досліджень щодо підготовки вчителя початкової школи у системі післядипломної освіти до оволодіння техніками здійснення конструктивної взаємодії з учнями, створення та оцінювання різноманітних контрольних робіт з математики, української мови, які є засобами моніторингу якості освіти. Метою статті є розкриття засобів здійснення моніторингу якості освіти, а саме: техніки здійснення конструктивної взаємодії з учнями, створення та оцінювання диференційованих за рівнем складності різноманітних завдань, зокрема, контрольних робіт з математики, української мови. Використано такі методи: теоретичний аналіз наукової літератури з метою з’ясування стану досліджуваної проблеми; моделювання, з метою опису техніки побудови конструктивної взаємодії з учнями, створення диференційованих за рівнем складності завдань розвивального характеру. Описано процес підготовки вчителя початкової школи у системі післядипломної освіти до оволодіння техніками здійснення конструктивної взаємодії з учнями, створення диференційованих за рівнем складності різноманітних завдань, зокрема, контрольних робітз математики, української мови. Подано приклади рольових тренінгів для вчителів початкової школи, спрямовані на розвиток професійних умінь щодо організації проблемно-пошукових діалогів у змодельованому освітньому середовищі. У тренінгових завданнях пропонується три ролі: вчителя, учнів та експертів. Пропонуються техніки поступового ускладнення текстової арифметичної задачі, складання і оцінювання диференційованих за рівнем складності контрольних робіт з математики, граматичні завдання до диктанту як засобу контролю знань і умінь учнів з української мови. У межах діючого експериментального дослідження всеукраїнського рівня доведено, що домінування у часі конструктивної взаємодії з учнями в освітньому процесі впливає на усвідомлення учнями своїх навчальних досягнень, вміння об’єктивно здійснювати самооцінювання та на прагнення до постійного саморозвитку та самовдосконалення.
ANÁLISE ÓTIMA PARA PORTFÓLIO DE INVESTIMENTOS APLICANDO O MODELO DE MARKOWITZ
Authors: Sarmento Vieira Allan , Aildon Abrantes Mendes Dênis
Published: January 2023

O objetivo principal desta pesquisa é propor um portfólio de investimento utilizando o modelo de Markowitz, para formar uma carteira de investimentos otimizada, com maior retorno e menor risco possível, dando ao investidor opções de escolha no mercado de ações. Nos procedimentos metodológicos foi construído um cenário que permitiu um estudo minucioso das 20 principais ações do 1º quadrimestre de 2014 do IBOVESPA compreendendo os períodos de janeiro de 2011 a dezembro de 2013, além disso, esta é uma pesquisa descritiva de abordagem quali-quantitativa, já que utiliza planilhas eletrônicas do Excel com destaque especial para ferramenta SOLVER, que é fundamental para aplicação do modelo de otimização e consequentemente permite qualificar o portfólio. Diante dos resultados encontrados foram feitas comparações e análises, o qual permitiu verificar que a carteira diversificada e otimizada apresentou maior retorno com o menor risco quando comparada a carteira formada por um investidor “ingênuo” que aplica aleatoriamente a mesma proporção para cada ativo que compõem o portfólio que no exemplo trabalhado foi de 20%. Contudo a aplicação do modelo de Markowitz permitiu encontrar um portfólio com proporções ótimas em cada cenário (Carteira MV), que detém o menor risco.
CIÊNCIA DE DADOS APLICADO À LOGÍSTICA
Authors: Batista Lucas Confortini , De Oliveira Marcus Rogério
Published: January 2023

A quantidade de dados cresce de maneira exponencial e é importante que a partir destes possam ser abstraídos conhecimentos e informações com intuito de gerar vantagens competitivas. Em vista disso, a ciência de dados surgiu com o intuito de extrair essas informações e interpretá-las com modelos matemáticos, estatísticos e algoritmos de inteligência artificial. Diante disso, o presente artigo com a utilização de modelos matemáticos e estatísticos tem por objetivo a aplicação de modelos de regressão na logística, a fim de obter predição de custos. Dentro desse contexto, este artigo apresenta a atuação da ciência de dados aplicada à área de logística, com introdução a termos, métodos e experiência prática, enfatizando a partição de predição de custos. A metodologia proposta abrange inicialmente uma pesquisa bibliográfica descritiva e posteriormente, analisa mais de 30 mil coeficientes aplicados a diferentes modelos de regressão. Os resultados permitem identificar a influência dos coeficientes no lucro líquido e a comparação de precisão dos modelos de regressão aplicados à predição de custos.
APLICAÇÃO DO INDICADOR OVERALL EQUIPMENT EFFECTIVENESS (OEE)
Authors: Bernardelli Hélio , Regattieri Carlos Roberto
Published: January 2023

Para as indústrias é de grande importância medir o desempenho dos equipamentos, uma vez que a forma com que estes são geridos colabora para o desempenho das empresas. o funcionamento dos equipamentos em sua maioria está relacionado a produção e a qualidade e eficiência desta determinam a sobrevivência da empresa. Este artigo tem como objetivo descrever o conceito da OEE e evidenciar um estudo de caso que traz um comparativo da medição de desempenho de duas máquinas pertencentes a uma indústria de produtos alimentícios. A metodologia utilizada foi de revisão de literatura com pesquisa no Google Acadêmico para a fundamentação teórica e pesquisa em campo em uma renomada indústria de produtos alimentícios. Os resultados encontrados apontam a importância do OEE dentro da indústria em questão, e deixam claro que conhecer o desempenho do equipamento  é de grande importância para verificar a produtividade, qualidade, desempenho e disponibilidade, fatores de importância para o crescimento da empresa e manutenção da qualidade daquilo que se produz.
FORMATION OF PALLADIUM NANOPARTICLES BY THE POLYOL METHOD:INFLUENCE OF ALKALINE CONDITIONS
Authors:   Instituto de Física del Sur (IFISUR), Departamento de Física, Universidad Nacional del Sur (UNS), CONICET.Av. L. N. Alem 1253, B8000CPB - Bahía Blanca, Argentina., Sánchez M. J. F. , Ritacco H. A. ,   Instituto de Física del Sur (IFISUR), Departamento de Física, Universidad Nacional del Sur (UNS), CONICET.Av. L. N. Alem 1253, B8000CPB - Bahía Blanca, Argentina., Sánchez M. D. ,   Instituto de Física del Sur (IFISUR), Departamento de Física, Universidad Nacional del Sur (UNS), CONICET.Av. L. N. Alem 1253, B8000CPB - Bahía Blanca, Argentina.
Published: January 2023

The effect of sodium hydroxide (NaOH) on the size of palladium (Pd) nanoparticles obtained by the simple polyol route was studied. Nanoparticles were synthesized at room temperature using palladium(II) chloride (PdCl2) and NaOH dissolved in ethylene glycol (EG) as reduction reaction promoters. No protective agents or stabilizers were used. We monitored the reaction kinetics and the growth of the nanoparticles by UV-vis spectroscopy and their crystallinity by powder X-ray diffraction (XRD) as a function of NaOH concentration. Crystallite size was evaluated from the diffraction pattern. We found that nanoparticle growth is strongly influenced by the NaOH: Pd molar ratio. Crystallite sizes from 2 to 24 nm were obtained for molar ratios ranging from 1 to 33. At lower concentrations of NaOH, the nucleation and growth process of the nanoparticles were found to be controlled by the reduction of the Pd ion precursors.At higher concentrations, the intermediate reduction of Pd-Cl-OH species determines the nanoparticle growth rate resulting in the formation of the smallest final-size nanoparticles.
Institutional approaches to the planning of sustainable use and protection of agricultural lands on the territory of individual land uses
Authors: Dorosh O. , Dorosh A. , Saliuta V. , Melnyk D.
Published: January 2023

The concepts of institutions and institutional approaches are studied. On the basis of institutional approaches to the planning of sustainable use and protection of agricultural lands of individual land uses, a system of institutes was formed, which include: the Institute of Land Management, the Institute of Land Monitoring, the Institute of the State Land Cadastre, the Institute of Local Self-Government, and the Institute of Local Traditions. The importance and effectiveness of these institutions, namely as systems and their relevance, are substantiated. The tools of these institutes, which allow for planning the sustainable use and protection of agricultural lands of individual land uses, as well as their implementation, have been analysed. The institute of land management and its tools, such as land management schemes and technical and economic justifications for the use and protection of lands of administrative territorial units, territories of territorial communities, and complex plans for the spatial development of the territory of the territorial community, are analysed in detail. The need to introduce a tool of land management regulations to expand the possibilities of the institute of land management in planning the use of territories located outside of settlements is justified. The importance of the institution of land monitoring is substantiated and the urgency of creating and implementing an automated land monitoring system is emphasized. The current state of the Institute of the State Land Cadastre was investigated and the expediency of expanding the list of objects of the State Land Cadastre by adding "agricultural land use" was substantiated. It was found that the significance of the institution of local self-government in the context of planning the sustainable use and protection of agricultural lands of individual land uses increases due to the expansion of the powers of local authorities in the process of decentralization of power. The need to take into account local agricultural traditions when planning the sustainable use and protection of agricultural lands of individual land uses has been confirmed.
Methodological Approaches to Modeling the Pathology of the Nervous System
Authors: I Bon Elizaveta
Published: January 2023

The pathology of the nervous system is of great interest to researchers in the field of medicine and physiology. However, today there is no clear understanding of the issues of experimental modeling of diseases of this system. The methods presented in this article for modeling diseases of the nervous system, in our opinion, should provide significant assistance to researchers in this area.
Assessment of Antioxidant and Antineoplastic Activities Blumea Lacera (burn. F) Leaves
Authors: Jaman Sadikuj
Published: January 2023

Blumea lacera (Burn. f.) DC. (Family: Asteraceae) is an important member of Bangladeshi natural plant resource and it is an herbaceous weed locally known as Kukursunga. Different parts of this plant are used traditionally to cure various diseases. But detail study on the antioxidant and antineoplastic potentials of Blumea lacera leaves, has not yet been done. Aim of this study is to examine the antioxidant and antineoplastic properties and quantify the different type of phytochemical content of the methanolic extract of leaves of Blumea lacera (MELB). MELB contained a rich polyphenol, flavonol, flavonoid and proanthocyanidins. MELB showed moderate cytotoxic effect against Artemia salina (brine shrimp nauplii) where its LD50 values was 66.12 µg/ml. In vitro antioxidant assay, MELB exhibited a remarkable capacity to scavenge the tested reactive species. MELB scavenged DPPH with an IC50 of 33.64 µg/mL and 42.69 µg/mL, respectively. In vivo antineoplastic assay, MELB significantly (P<0.05) decreased viable cell count and increased the survival time of EAC cell bearing mice. Hematological profiles were also restored significantly (P<0.05) to normal levels in MELB treated mice as compared to untreated EAC control mice. In addition, fluorescence microscopic view of EAC cells derived from MELB-treated group showed apoptotic characteristics in treated cells compared to untreated EAC control. our findings suggest that methanolic extract of Blumea lacera leaves(MELB) might be a potential agent with antioxidant properties for prevention of cancer and has the merit for further investigation in isolating its active constituents.
Age-related deformity of the arteries, inflammation and atherosclerosis. What is primary, what is secondary?
Authors: Ivanovich Ermoshkin Vladimir
Published: January 2023

After the publication of several articles on the possible cause and mechanism of atherosclerosis requires s some explanation for the better understanding of this problem. Readers can arose pull the question of why atherosclerosis is accompanied by inflammation? Or is it on the contrary, is inflammation accompanied by atherosclerosis? What does official medicine say about this? What is primary, what is secondary?
Observation of Youth in Sociological Context
Authors: Taghi Sheykhi Mohammad
Published: January 2023

Sociology as a science of society evaluates the youth from different perspectives. Youth as one-fifth of population in most societies are facing new needs and services. In more developed world, they are almost fulfilled because of the availability of infrastructures, whereas in many developing societies because of such a vacuum, many youth are deprived of their required services and essentials of today's life. However, achievement of modernity has to a large extent provided the youth with new opportunities in many countries. Such a transition has led the youth to growing awareness. When the conditions are favorable, young people will be able to use their ability and capacity much better, or in other words, they will perform their functions/ duties satisfactorily. In such a situation, the society as a whole moves in a positive way. Many have not yet been able to provide their youth to access to education to be used in future creativity and development. Improving the quality of basic education has been highly emphasized by scholars. In many developing countries, many of those who drop out of school in early stages become child-labor; a phenomenon affecting their entire life in a negative manner. Developing societies have a wide need for different skills in various fields, which must be provided by the youth in any society.
Diabetics and Sexual Disorders: Why both Men and Women with Diabetes Suffer from Impotence and Lack of Sexual Desire
Authors: Abdelrahim Ibrahim Humaida Ibrahim
Published: January 2023

The main objective of this study was to investigate the prevalence of sexual disorders in diabetics, owing todiabetes constitutes a growing public health problem, leading to a variety of dysfunctions such as cardiovascular, psychological, and sexual dysfunctions, that is why Diabetes is a well-known cause of sexual disorders, with prevalence rates approaching 50% in both type 1 and type 2 diabetes, but the determinants of sex dysfunction in diabetic men as a result of the principal cardiovascular risk factors, such as hypertension, and also overweight obesity, in addition to metabolic syndrome, smoking, and sedentary lifestyles. Moreover, sexual disorders considered as important predictors of the development of major complaints in diabetic patients, on the other hand, the debate as to whether diabetes link with sexual dysfunction or not, is an issue of controversy, moreover,diabetic women suffer from the same neurovascular complications that contribute to the pathogenesis of SD in men, however, results of sexual functioning of diabetic women are less conclusive. Conclusion: extending beyond the specific effects on sexual dysfunction in men and women with diabetes, the adoption of these measures promotes a healthier life and increased well-being, which in turn, may help to reduce the burden of sexual dysfunction.
Concept for Automatic Multi-object Organ Detection and Segmentation in Abdominal CT Data
Authors: Mastmeyer Andre
Published: January 2023

The ability to generate 3D patient models in a fast and reliable way, is of great importance, e.g. for the simulation of liver punctures in a virtual reality simulation. The aim is to automatically detect and segment abdominal structures in CT scans. In particular among the selected organ group, the pancreas poses a challenge. We use a combination of random regression forests and U-Nets to detect bounding boxes and generate segmentation masks for five abdominal organs (liver, kidneys, spleen, and pancreas). Proof of concept training and testing was carried out on 50 CT scans from various public sources. Preliminary results showed Dice coefficients of up to 0.71. The proposed method can theoretically be used for any anatomical structure, as long as sufficient training data is available.
Family counseling with a child with learning disabilities or disability
Authors: Theofilidis Antonis Th.
Published: January 2023

In this study we present the term counseling that should be used by parents who acquire a child with a disability or learning disabilities as well as the role of counselor and parent during the counseling process. Aim: The main purpose of the article is to approach the concept of family counseling with a child with learning disabilities or disability. The relevant counseling that should be followed is presented, the role of the counselor is also discussed, as well as the role of the parents in the process. Method: a review of the literature related to family counseling was made and the most representative articles on the concept were selected. Conclusions: Counseling for families with children with special needs, whether it is some kind of disability or a special learning disability, can offer a better quality of life, peace of mind and clarity in order to help the child properly and effectively.
What the Body Does to A Drug: Pharmacokinetics
Authors: Bereda Gudisa
Published: January 2023

Pharmacokinetics may be defined as the study of the dynamic movements of foreign chemicals (xenobiotics) during their passage through the body and as such encompass the kinetics of absorption, distribution, biotransformation/metabolism and excretion. Absorption is the process that brings a drug from the administration, e.g., tablet, capsule, into the systemic circulation. Bioavailability is the fraction of the originally administered drug that arrives in systemic circulation and depends on the properties of the substance and the mode of administration. It can be a direct reflection of medication absorption. Distribution describes how a substance is spread throughout the body. This varies based on the biochemical properties of the drug as well as the physiology of the individual taking that medication. In the body, a drug may be protein-bound or free. Only free drug can act at its pharmacologically active sites, e.g., receptors, cross into other fluid compartments, or be eliminated. Metabolism is the processing of the drug by the body into subsequent compounds. Excretion is the process by which the drug is eliminated from the body. The pharmacokinetic term half-life (t1/2) refers to the time taken for half the initial dose of medicine administered to be eliminated from the body. After three to five half-lives the drug is considered undetectable and unable to exert a pharmacodynamic effect.
Entrepreneurial assistance for down syndrome children and caregivers in the DSI community
Authors: Katuruni Innas Rovino , Praptiwi Rahma Nur , Untari Sri Isti , Rahmi Iftita , Ariyanti Tika Dwi
Published: January 2023

A vulnerable population, people with disabilities frequently face discrimination in the workplace. They frequently struggle to find employment in the formal sector because there aren't enough workplace amenities to support them and there aren't enough positions that match their skills. Because there aren't many jobs available in Indonesia for those with disabilities, starting a business is an excellent career option. This community service program aims to provide training and assistance for people with disabilities, especially people with Down syndrome and their caregiver who are members of the Down Syndrome Indonesia (DSI) community. This activity was conducted in three stages, including webinars, psychological testing to identify participants' strengths, workshops, and entrepreneurship mentoring.  The results of this program were increased knowledge and skills of people with Down syndrome and their caregivers regarding interests and talents and the process of starting and developing a business. Thus, it is hoped that businesses built by people with Down syndrome and their caregivers can last a long time so that they can achieve economic independence.
Działalność charytatywna w Braniewie w latach trzydziestych XIX wieku w świetle kroniki parafii ewangelickiej
Authors: Jodkowski Marek
Published: January 2023

Proboszcz parafii ewangelickiej w Braniewie, ks. Leberecht Ferdinand Bock (lata urzędowania 1829-1845), prowadził jej kronikę, w której zawarł informacje dotyczące działalności charytatywnej w tym mieście. Przede wszystkim uwypuklił formy pomocy chorym i wymagającym wsparcia w czasie epidemii cholery w 1831 r. Niekwestionowaną rolę odegrało przy tym Towarzystwo na rzecz Pomocy i Ratunku Chorym (Verein zur Hilfsleistung und Rettung der Kranken). Po jego wygaśnięciu czołowym inicjatorem różnorodnych form troski o potrzebujących okazał się, ustanowiony kilka lat wcześniej, Zarząd na rzecz Ubogich (Armen-Direktorium), będący najprawdopodobniej jedną z deputacji miejskich. Od 1833 r. jego spotkania odbywały się regularnie, co miesiąc. W 1839 r. erygowano Towarzystwo Pomocy Biednym (Hilfsarmenverein), dzięki któremu zintensyfikowano wsparcie udzielane potrzebującym. Dzięki licznym inicjatywom charytatywnym zwalczano w Braniewie biedę i ubóstwo, eliminowano włóczęgostwo oraz żebractwo, a także gwarantowano doraźną, a w niektórych przypadkach nawet długotrwałą pomoc biednym członkom miejscowej społeczności.
Biblical Sources of Ecclesiology in Expositio Symboli Apostolorum by Johannes Marienwerder
Authors: Karczewski Marek
Published: January 2023

The structure of the article: the first section discusses the significance of Expositio in the light of other work by Johannes Marienwerder. The second section is concerned with the principal qualities of the Church in their relation to the Scripture, so as to examine the ecclesiological element in the interpretation of the Article 9 of the Apostles’ Creed and in the remainder of Expositio. That section concludes with findings from the analysis of how biblical texts are used in Marienwerder’s ecclesiological disquisition. Finally, attention is drawn to the relation between the conception of the Church in Expositio and the reformatory postulations advanced in the ecclesiastical and scholarly circles of Bohemian Prague in the second half of the fourteenth century. The mission of the Church is closely aligned with the biblical testimonies, which shed light on its nature and the purpose of its existence. The Holy Scripture also provides knowledge about the principal characteristics of the Church: unity, dignity and constancy. The biblical texts also supply a foundation thanks to which the errors and heresies directed against the Church can be repudiated. The considerably emphasized importance of the Scripture was characteristic of the new theology deriving from the current of devotio moderna. This study constitutes a preliminary to further research on the ecclesiology of Marienwerder.
Przemiany mentalności mieszkańców wsi na przełomie XIX/XX wieku (rejestrowane w dyskursach publicznych oraz w źródłach etnohistorycznych)
Authors: Józefów-Czerwińska Bożena
Published: January 2023

Proces kulturowo-społecznych przemian mieszkańców wsi przypadający na przełom XIX/XX w. był już przedmiotem wielu naukowych rozważań. Jednak pewne konteksty warto ponownie zaakcentować, czerpiąc ze źródeł etnohistorycznych w odwołaniu do analiz dyskursów publicznych (pojawiających się w prasie). W omawianym okresie trwała systemowa polityka rusyfikacji. Przeciwstawiły się temu zjawisku zróżnicowane środowiska polskich elit, dostrzegające konieczność wzmocnienia więzi chłopskich rodzin z polską tożsamością narodową. Postępowe środowiska, działacze społeczni, duchowni podjęli misję szerzenia oświaty wśród ludu, dostrzegając konieczność zwalczania powszechnie jeszcze wówczas występującego analfabetyzmu, rejestrowanego wśród mieszkańców wsi. Nadzieję pokładano zwłaszcza w edukacji generacji młodych chłopów, prowadzonej w rodzimym języku, kulturze, osadzonej w ojczystej historii. Niewątpliwie w tym procesie zasłużyło się wielu przedstawicieli ówczesnych elit, a oprócz nich ważną rolę odegrała również prasa. Tej tematyce poświęcone są niniejsze rozważania.
Rare case of extracranial chordoid meningioma adjacent to the carotid sheath: illustrative case
Authors: Jeong Seung W. , Moran Michael , Elhamdani Shahed , Kusyk Dorian M. , Xu Chen , Gyure Kymberly , Williamson Richard
Published: January 2023

BACKGROUND

Chordoid meningioma is a rare World Health Organization (WHO) grade 2 variant of meningioma with histological features resembling those of a chordoma. This tumor type is known for having an aggressive clinical course with a propensity for local recurrence. Most cases occur within the cranium, more specifically around the cerebral convexities. Although extracranial meningiomas of various subtypes have been documented, extracranial meningioma with a chordoid subtype is an extremely rare entity.

OBSERVATIONS

The authors herein report the case of a 51-year-old female who presented with a chief complaint of dysphagia and was found to have a neck mass abutting the carotid sheath. The patient underwent resection and final pathology results revealed a WHO grade 2 chordoid meningioma.

LESSONS

This case report demonstrates an atypical case of an extracranial chordoid meningioma adjacent to the carotid sheath. To the authors’ knowledge, this is the first reported case of a chordoid meningioma occurring within the soft tissue of the neck.
Concomitant brain abscess and spinal cord abscess in an immunocompetent teenage male: illustrative case
Authors: Virtanen Piiamaria S. , Jimenez Med Jimson D. , Horak V. Jane , Desai Virendra R. , Manaloor John J. , Raskin Jeffrey S.
Published: January 2023

BACKGROUND

Multiple bilateral brain abscesses occur rarely in immunocompetent patients. Hematogenous spread to the central nervous system (CNS) allows suppuration and abscess formation in the privileged immune environment of the CNS; hematogenous spread to the spinal cord is extremely rare and the combination of multifocal brain abscesses and intramedullary abscesses has not been reported. This report presents a rare presentation and diagrams a treatment algorithm involving iterative minimal access surgeries and prolonged medical management.

OBSERVATIONS

The authors present a case of an 18-year-old male with numerous multifocal and bilateral intraparenchymal abscesses and a medically resistant C5 intramedullary spinal cord abscess. The symptomatic patient had a left oculomotor palsy and left hemiparesis, ultimately undergoing ultrasound-guided aspiration of abscesses in the left frontal and left cerebral peduncle. Following transient motor improvement, he evolved tetraparesis prompting spinal cord imaging and emergent ultrasound-guided needle aspiration of an occult C5 intramedullary spinal cord abscess. The patient received appropriate medical therapy, completed inpatient rehabilitation, and made a full recovery.

LESSONS

Needle- and ultrasound-guided catheter drainage of CNS abscesses should be considered for symptomatic lesions. Following the neurological examination closely is extremely important; if the expected neurological improvement is delayed or regresses, then expanded imaging is warranted.
Endovascular embolization and needle aspiration of a life-threatening cervical hematoma due to a neurofibromatosis type 1–associated arteriovenous fistula: illustrative case
Authors: Kojima Daigo , Akamatsu Yosuke , Aso Kenta , Kimura Kazuto , Matsumoto Yoshiyasu , Sato Shinpei , Kashimura Hiroshi , Kubo Yoshitaka , Ogasawara Kuniaki
Published: January 2023

BACKGROUND

In cases of neurofibromatosis in which the bleeding source is considered strongly related to a neurofibroma, an open surgical approach could risk uncontrollable bleeding from the vascular wall infiltration by neurofibroma. The case of a neurofibromatosis type 1 (NF1)–associated arteriovenous fistula presenting with a life-threatening cervical hematoma that was successfully treated with alternative treatment is described.

OBSERVATIONS

A 68-year-old woman diagnosed with NF1 presented with sudden onset of a spontaneous right cervical mass. Neck imaging on admission showed a massive subcutaneous hematoma with tracheal deviation and abnormal vascular structure in the hematoma. Digital subtraction angiography showed that an arteriovenous fistula (AVF) fed from a vertebral artery located within the hematoma cavity was the primary source of bleeding and feeding arteries from the occipital artery to the neurofibroma. Embolization of the cervical neurofibroma, as well as the AVF, was performed to reduce the secondary risk of bleeding, and was accomplished. After endovascular treatment, needle aspiration of the cervical hematoma was performed to reduce the mass effect.

LESSONS

When performing open surgery via tissues with neurofibromatosis proliferation, uncontrollable bleeding can occur. Therefore, endovascular embolization and needle aspiration of the hematoma should be considered in this setting.
A Critical Analysis of the Democratic Argument for Teaching Science: The Case of Cell Phones
Authors: Kaliampos George , Kotsis Konstantinos T. , Kornelaki Athina C.
Published: January 2023

A number of diverse arguments have been proposed by researchers of science education regarding the reason science should be taught in schools. These arguments inevitable play a key role in the curriculum designed by policy makers. The present study turns its attention into the democratic argument and tries to explore its validity through a distinct socio-scientific issue that citizen is likely to come across in their everyday life, that of radiation emitted from cell phones. In particular, it tries to study the required knowledge of physics that will enable individuals to deal with the emission of radiation from cell phones in an effective way. Moreover, drawing from sharp conflicts that have arisen during the last years around the world between citizens and cell phone companies regarding the installation of cell towers within residential areas, it tries to record information about different places in the world where the cell phone controversy has made headline news.
Coverage of influenza vaccination of patients with diabetes and determination of barriers for implementation of vaccination
Authors: Власенко І. О. , Давтян Л. Л.
Published: January 2023

People with diabetes (PWD) are considered to be at high risk of developing severe influenza complications that can lead to hospitalization and sometimes death. It is because of the high risk of developing severe complications that WHO recommends seasonal influenza vaccination (SIV) for PWD.
The purpose of the work is to establish the level of coverage of vaccination in PWD and to identify barriers to vaccination in this group in order to overcome obstacles.
We analyzed data on the coverage of SIV in PWD and studied the problems of low adherence to vaccination in PWD. We used content analysis, bibliosemantic, analytical, generalizing analyses. An insufficient level of vaccination coverage of PWD has been established. Barriers to vaccination in PWD have been identified. Barriers can be: age, health status, allergic reactions and chronic diseases of people, lower level of education, gender and their employment in economic activities. At the same time, gaps in the knowledge of health care provider, insufficient involvement of endocrinologists and diabetologists in informing PWD about vaccination, a limited number of imported vaccines, and low physical and economic accessibility of vaccines negatively affect the coverage of SIV. A significant factor influencing the level of vaccination coverage of people is their vaccination hesitation. Pharmacists should actively participate in the vaccination campaign by raising public awareness and providing advice to PWD who regularly visit pharmacies. To increase the vaccination coverage of PWD, it is necessary to introduce training programs for doctors and pharmacists to attract them to influenza vaccination companies. Simultaneously conduct educational campaigns and education of PWD. It is advisable to organize a free flu vaccination in medical and diagnostic diabetic hospital (institutions) to increase the physical and economic accessibility of vaccination for PWD. A large number of studies showing the cost-effectiveness of SIV in PWD should be a significant factor for health authorities to improve measures to increase the level of coverage of SIV in patients in this risk group.