bluuebunny/crossref_metadata_2025 huggingface dataset:
RANCANG BANGUN APLIKASI POINT OF SALES PADA RUMAH MAKAN HARAPAN BUNDO BERBASIS ANDROID
Authors: Salsabil Harits , Kahfi Ahmad Hafidzul
Published: January 2025

Harapan Bundo is one of the restaurants engaged in the culinary business. The current system at Harapan Bundo restaurant still relies on a manual method, which involves writing on paper and frequently leads to errors while compiling transaction reports. This research aims to design and build an Android-based Point of Sale (POS) application. The system development method uses the iterative waterfall model. The research results in a point-of-sales application built with a flutter framework that can view sales transaction reports, calculate food stock, print transaction receipts, and export sales records in Excel format. The developed application functions effectively and fulfills the requirements for enhancing business development.
PENGEMBANGAN FRAMEWORK DATA MINING BERBASIS DEEP NEURAL NETWORK DENGAN EKSPLORASI TEKNIK TRANSFER LEARNING UNTUK PREDIKSI DAN KLASIFIKASI DATA
Authors: Nurlaela Lela , Suhanda Yogasetya , Sopian Adi , Dewi Christine Sientta , Syahrial Riza
Published: January 2025

The digital transformation in the era of the Industrial Revolution 4.0 has driven the adoption of deep learning technology for data analysis across various sectors, including healthcare, education, and agriculture. This study aims to develop a data mining framework based on deep neural networks by exploring transfer learning techniques to enhance the accuracy and efficiency of prediction and classification processes. The research employs a research and development (R&D) approach with systematic stages, including a literature review, framework design, data collection and processing, framework implementation, and performance evaluation. The developed framework was tested in three primary data domains: healthcare, education, and agriculture. The data underwent cleaning, normalisation, and augmentation to improve quality and variety. The framework was implemented using the TensorFlow library, leveraging pre-trained models such as ResNet50 and InceptionV3. The evaluation used accuracy, precision, recall, F1-score, and training time efficiency metrics. The results demonstrate that the framework achieved an average accuracy of over 90%, improving training time efficiency by up to 60% compared to training from scratch. The transfer learning technique enabled the utilisation of pre-trained models to enhance prediction performance while requiring smaller training datasets. This study also identified key challenges in implementing deep learning technology in Indonesia, including limited infrastructure and low interpretability of analytical results. Consequently, the framework was designed to support interpretability through intuitive data visualisation and flexibility to adapt to various sectors. This framework is not only academically relevant but also practical, providing significant contributions to data-driven decision-making and improving organisational competitiveness in Indonesia.
Serum miR-329-3p as a potential biomarker for poor ovarian response in an in vitro fertilization
Authors: Kim Jung Hoon , Kim Hye-Ok , Lee Su-Yeon , Park Eun-A , Choi Kyoung Hee , Kang Kiye , Yu Eun Jeong , Koong Mi Kyoung , Lee Kyung-Ah
Published: January 2025

Objective: Several miRNAs have been identified as differentially expressed in patients with poor ovarian response (POR) compared to those with normal responses. This study aims to assess the potential of serum miR-329-3p as a biomarker for diagnosing POR.Methods: We conducted a Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis to confirm the target genes of miR-329-3p. KGN cells were transfected with both miR-329-3p mimic and inhibitor to assess the differential expression of these target genes. In accordance with the Bologna criteria, we enrolled 16 control patients and 16 patients with POR. We collected patient samples, including serum from day 2 and the human chorionic gonadotropin (hCG) day, as well as granulosa and cumulus cells, to validate the expression of miR-329-3p using quantitative real-time polymerase chain reaction.Results: KEGG pathway analysis revealed that miR-329-3p targeted adenylyl cyclase 9 (ADCY9) and protein kinase A subunit beta (PRKACB), both of which are involved in ovarian steroidogenesis. In KGN cells treated with a miR-329-3p mimic, ADCY9 and PRKACB expression levels were significantly reduced (p<0.05). Elevated levels of miR-329-3p suppressed aromatase expression and 17β-estradiol production by modulating ADCY9 and PRKACB in KGN cells. These effects were also observed in POR patients. Follicle-stimulating hormone receptor (FSHR) expression was diminished in the granulosa cells of POR patients. On day 2, on hCG day, and in granulosa cells, miR-329-3p exhibited high expression levels in the serum of POR patients.Conclusion: miR-329-3p exhibited increased expression in granulosa cells and in the sera of POR patients. Consequently, we propose that miR-329-3p may be a potential biomarker for the diagnosis of POR.
Blood Cell Disease Prediction with Machine Learning
Authors: Arshad Ateeqa , Fatima Arooj , Tahir Asad , Fatima Rida , Khalil Mudasira
Published: January 2025

Our body has cells that provide oxygen to our cell nucleus, called red blood cells (RBC).  The other cells that are fighting the disease in our body are called
the White Blood Cell (WBC), and some types of cells prevent bleeding with clotting processes. There are three main types of blood cells. If we have some disorder in these cells, then our body faces diseases like leukemia, lymphoma and myeloma. Blood cell diseases can be identified using blood cell image symptoms, causes, and present conditions. Blood smear images with surrounding images of red, platelet, and white cell breakdown play an important role in assessing and diagnosing a large range of illnesses, including infection, disease, and leukemia. Due to the segmentation or breakdown procedures, some image processing techniques are performed to improve picture detection quality. Blood cell segmentation remains a serious challenge. That’s why deep learning technology is used to get the blood cell images clearly with the application of cutting-edge technology for the white blood cells, platelets and red blood cells in blood smear images. The accuracy of blood cell smear images required for automatic illness identification has been demonstrated in previous research experiments. To tackle this blood cell disease issue and optimize the system's performance to detect the diseases present in blood cells, we can find through their images by proposing deep learning.
Design and Experimentation of Peltier-Based Thermoelectric Cooling Vaccine Carrier Box
Authors: Khan Yousaf , Khan Taimur Ahmed , Ilyas Muhammad
Published: January 2025

Vaccines are typically administered during routine immunization programs, with a critical focus on maintaining a cold chain system. The cold chain system plays a pivotal role in ensuring the efficacy of vaccines. In this paper, a portable solar-powered vaccine carrier box based on the Peltier Effect for effective vaccine cooling is designed and experimented with. The system has four 12V DC 3.5A Thermoelectric Cooler (TEC) Peltier Modules, with strategically positioned heat sinks outside the cooling box. Additionally, the setup incorporates a 12V 180W Solar Panel for daytime power generation and eight Rechargeable Li-Po 3.7V 4500mAh batteries for uninterrupted operation for 3 hours. The experimentation involved three distinct conditions. Firstly, a gradual temperature decrease was observed in the empty cooling box. Secondly, with the introduction of 10 sterile glass vaccine tubes filled with water, the temperature decreased more slowly, reaching 15°C in 62 minutes and 8°C after 90 minutes. Lastly, with 6 vaccine tubes, it took approximately 55 minutes to reach 15°C and about 90 minutes to achieve the desired 8°C temperature. The system exhibits a Coefficient of Performance of 0.42. The results emphasize the efficient cooling performance of the developed storage system, highlighting its capability to maintain temperatures below 15°C, a critical factor in preserving vaccines.
Construction of Criminal Conspiracy in Corruption Crime
Authors: S Mery Rohana Lisbeth , Gultom Elfrida Ratnawati , Ginting Jamin
Published: January 2025

The regulation of criminal conspiracy in corruption crimes in Indonesia, especially under Article 15 of the Corruption Eradication Law, raises various fundamental issues that have the potential to disrupt the principle of justice in law enforcement. This research aims to identify and analyze problems in the regulation of criminal conspiracy and provide recommendations for improvements that are fairer and in accordance with legal principles. The method used is normative research with a legal approach and qualitative descriptive analysis. Data was collected from primary, secondary, and tertiary legal sources to provide a comprehensive overview of the issues studied. The study found that the definition of criminal conspiracy in the GCPL is unclear, the sanctions are disproportionate, and the merging of the provisions with attempt and aiding and abetting has resulted in difficulties of proof. Recommendations include the need for a clear definition, separation of rules based on the nature of the act, application of the principle of proportionality in sanctions, and rewards for perpetrators who disclose conspiracies. With the proposed reforms, the law on criminal conspiracy should better reflect the principles of justice, provide legal certainty and support efforts to fight corruption effectively and humanely.
The Sub-inhibitory Effect of Azithromycin and Ciprofloxacin on virF Gene Expression in Enteroinvasive Escherichia coli and Shigella flexneri
Authors: Shahsavan Mohadeseh , Firoozeh Farzaneh , Bakhtiyari Mahmood , Pourrostami Kumars , Tavakoli Mahnaz , Hatami Shiva , Mohammadzadeh Mohammad
Published: January 2025

Background: Bacillary dysentery is an invasive bacterial gastroenteritis that damages the colon epithelium and leads to bloody diarrhea. Enteroinvasive Escherichia coli (EIEC) and Shigella flexneri are two major etiologic agents of the disease. The virF gene is a transcriptional regulator of the virulence genes involved in the invasion of these bacteria. Previous studies have shown that sub-minimum inhibitory concentrations (sub-MICs) of antibiotics have significant effects on bacterial virulence. Objectives: This study aimed to evaluate the effects of sub-MICs of ciprofloxacin and azithromycin on S. flexneri and EIEC. Methods: Prototype strains of both bacteria were treated with sub-MICs of 1/2, 1/4, and 1/8 of ciprofloxacin and azithromycin antibiotics. Changes in the expression of the virF gene in antibiotic-treated samples compared to control samples were analyzed using relative real-time polymerase chain reaction (PCR). Results: The mean expression of the virF gene in all sub-MICs of ciprofloxacin was increased in both S. flexneri and EIEC, while a down-regulation was observed in sub-MICs of azithromycin. These gene expression changes were dose-dependent. Conclusions: The results demonstrated that the virulence of S. flexneri and EIEC is affected by sub-MICs of azithromycin and ciprofloxacin. Given that azithromycin, unlike ciprofloxacin, reduces the severity of infection at sub-MICs, it is a more appropriate choice with a lower risk for treating acute infections caused by these bacteria.
Evaluation of Surgical Antibiotic Prophylaxis Guideline Adherence: A Cross-Sectional Study of Two Iranian Teaching Hospitals
Authors: Farasatinasab Maryam , La'li Azadeh , Zibafard Asma , Khaleghian Mohsen , Nasiripour Somayyeh , Alizadeh Otaghvar Hamidreza , Tanasan Puya , Mohammad Soleymani Saeed
Published: January 2025

Background: Prophylactic antibiotics can reduce post-surgical infection rates, but their improper use in surgery remains a significant concern. This misuse leads to adverse drug reactions, increased bacterial resistance, and unnecessary hospital costs. Objectives: This study aimed to examine and compare prophylactic antibiotic prescribing practices in general surgery departments at two Tehran university hospitals, in relation to established guidelines. Methods: A cross-sectional study was conducted on 194 surgical patients. Data collection included demographic details, surgery type, and antibiotic prophylaxis protocols, covering medication type, dosage, pre-surgical timing, and prophylaxis duration. Results: The study included 27.8% clean surgeries and 72.2% clean-contaminated surgeries. Cefazolin was the primary antibiotic prescribed. According to the American Society of Health-System Pharmacists (ASHP) treatment guidelines, 10% of patients received antibiotics without proper indication. Among the 90 cases requiring antibiotic prophylaxis, appropriate antibiotic selection occurred in 39.0% of cases at Rasul Akram Hospital and 41.5% at Firouzgar Hospital. In these cases, errors were noted in dosing (79.8%), pre-operative timing (97.4%), and administration protocol (100%). Only 33% of cases followed the optimal prophylaxis duration. Conclusions: These hospitals require an evidence-based antibiotic prescription program that adheres to clinical guidelines and includes close monitoring of implementation. Regular training and review of clinical guidelines are essential for all healthcare professionals.
A window into the vascular endothelium in COVID-19: Nails
Authors: Karstarli Bakay Ozge Sevil , Cetin Niyazi , Bakay Umut , Cinar Gokhan , Goksin Sule
Published: January 2025

Introduction: Endothelial damage is associated with acute and long-term Coronavirus disease 2019 (COVID-19) complications. Proximal nailfold capillaries are windows for monitoring important microvascular changes associated with endothelial dysfunction. Objective: We aimed to use dermoscopy to examine the proximal nailfold capillaries of COVID-19 patients and identify microvascular changes. Methods: A prospective study was designed to evaluate the dermoscopic features of proximal nail fold capillaries in mild to moderate COVID-19 patients and healthy controls between June 2022 and December 2023. The patients underwent their initial dermoscopic examination 2 weeks after the onset of symptoms, followed by a follow-up evaluation 10-14 months later. Results: The study included 46 patients with mild-to-moderate COVID-19 and 62 healthy controls. The presence of avascular areas (P<0.001), meandering capillaries (P=0.016), microhemorrhages (P=0.007), and enlarged capillaries (p=0.009) in the proximal nail fold is significantly higher in COVID-19 patients than in healthy controls The capillary architecture was disorganized (P=0.002) and density reduced (P<0.001) in COVID-19 patients compared to healthy controls. In the follow-up examination, microvascular changes were observed to regress. Conclusions: Proximal nailfold dermoscopy is an effective, low-cost, and easily accessible method that enables observing microvascular changes in COVID-19 patients.
Di-Genic Inheritance in Genodermatoses: Insights from Two Consanguineous Cases in a Reference Lebanese Center within the Middle East and North Africa (MENA) Region
Authors: Kadhi Ayat , Hamie Lamiaa , Eid Edward , Nemer Georges , Kurban Mazen
Published: January 2025

Introduction: Genodermatoses refer to a group of heterogenous rare genetic diseases with cutaneous expression. Several genodermatoses present with multisystem involvement that can range from mild to life-threatening conditions leading to increased morbidity and mortality. Objective: Given the paucity in the literature in the field of genodermatoses especially in the Middle East and North Africa (MENA) region and building up on the first established genodermatoses database based in Lebanon, this article aimed to decipher the genetic basis of 2 different types of skin-inherited diseases (androgenic alopecia and vitiligo). Methods: Herein, we propose the first di-genic model of inheritance which could be responsible for these 2 diseases, using Whole Exome Sequencing (WES) and GEO datasets. Results: We identified 2 gene variants FOXC1(p.His484Tyr) and SMARCD1 (p.Arg351Cys) responsible for androgenic alopecia and HPS1(p.Ser566Ter) and ITK (p.Pro521Leu) responsible for  vitiligo. Further analysis using GEO datasets, confirmed the connectivity between the genes involved in each each disease. Conclusion: This study identified novel candidate disease genes and inheritance model that could explain the underlying phenotypes that could open the doors for a better-guided genomic approach for personalized treatment and early diagnosis.
Politics and International Relations provision in UK higher education
Authors:   The British Academy
Published: January 2025

Politics and International Relations is a broad and complex subject area that includes multiple overlapping sub-disciplines. There continues to be strong demand for this disciplinary area in the UK, with a particularly notable increase in postgraduate taught student numbers over the past decade. The subject area enjoys a strong global reputation, attracting students and scholars from across the world. The expansion of the discipline has also resulted in various forms of diversification of both students and staff. Evidence suggests a thriving research sector for the discipline, with funding streams increasing and diversifying over recent years. The discipline also demonstrates significant impact beyond academia, reinforcing its relevance and importance. This report serves as a resource for the Politics and International Relations community to better understand the trends experienced across UK from a higher education policy perspective. It serves as an evidence base for future activity related to the health and sustainability of the discipline.
The Prospects for the Use of Invasive Species in the Process of Landscaping the City of Vanadzor
Authors: Vardanyan Zaruhy , Virabyan Mane
Published: January 2025

Key words: greening, green plantings, invasive species, climate change, species composition change, favorable conditions

In the context of climate change, opportunities for the introduction of invasive species, their adaptation, favorable growth and development in new places are increasing. Many invasive plant species are used for landscaping. Adapting favorably to climatic and environmental conditions, they displace previously used species.
The research was carried out on green spaces in the city of Vanadzor, Lori region of the Republic of Armenia.
Associated tree species make up the studied plants 72.7 %, and main types of trees 27.2 %, and Аcer Platanoides L. makes up 18.1 %, Carpinus betulus L. 22.7 %, Populus alba L. 4.5 %, Salix albav. 9 %, Tilia cordata Mill 13,6 %, Lonicera caucasica L. 13.6 %, Cornus mas L. 9 %, Jasminum fruticans L. 4.5 %, Betula litwinowii 4.5 %. The largest number are individuals of the Carpinus betulus L., probably due to the barrier-forming and noise-absorbing properties of the latter.
In the field of landscaping in the city of Vanadzor, due to climate change, invasive plant species that quickly adapt and have aesthetic value are promising. The largest number of invasive species found in various green areas of the city of Vanadzor is Catalpa L. in Artsakh Park - 35.4 %, Paulownia L. 10.4 %, B. Litwinowii 31.25 %, Magnolia L. 6.25 % and J. Sabina L. 16.6 %.
In Silico Study of Bioactive Compounds Fucoxanthin and Fucoidan from Sargassum echinocarpum as Anti-Cancer Agents Targeting Caspase-3 Protein
Authors: Mualimin Lulus , Arum Mentari
Published: January 2025

Cancer is a complex disease characterized by disruptions in cell regulation mechanisms, leading to abnormal or uncontrolled cell growth and the ability to spread to other parts of the body. The caspase-3 protein plays a crucial role in the apoptotic mechanism and is a key target in cancer therapy. Bioactive compounds from the brown alga Sargassum, such as fucoidan and fucoxanthin, show significant potential as anticancer agents through mechanisms including apoptosis induction, cell cycle arrest, and metastasis inhibition. This study employed an in silico method to investigate the interaction between the natural ligands fucoidan and fucoxanthin and the target protein caspase-3, simulating their potential as anticancer drug candidates. The analysis revealed distinct interactions for each ligand with the target protein, as indicated by their binding affinity values. The interaction between fucoidan and caspase-3 resulted in a binding affinity value of ∆G -4.7 kcal/mol, which was lower in effectiveness compared to the interaction between fucoxanthin and caspase-3, with a binding affinity value of ∆G -7.7 kcal/mol. This suggests that fucoxanthin exhibits stronger anticancer activity through its interaction with caspase-3 compared to fucoidan. Meanwhile, toxicity tests showed that fucoidan has a lower toxicity profile than fucoxanthin, particularly in terms of LD₅₀ values and active/inactive toxicity parameters. These findings indicate that fucoxanthin has potential as anticancer drug candidates. Further research is needed to optimize their therapeutic efficacy and safety profiles.
Pengaruh Manajemen Hutang, Piutang, Persediaan, terhadap Profitabilitas dengan Arus Kas sebagai Variabel Intervening Pada Perusahaan Sektor Kesehatan yang terdaftar BEI
Authors: Karina Sekar Rachmadanti  , Slamet Riyadi
Published: January 2025

This Research Has The Purpose Of Analyzing The Effect Of Debt Management, Receivables Management, And Inventory Management On Company Profitability With Cash Flow As An Intervening Variable. The Techniques Applied Include Quantitative Descriptive Research Design, With Statistics Taken Through The Annual Reports Of Health Sub-Sector Companies Listed On The Stock Exchange! Indonesia During The Period Of 2019 To 2022. The Research Population Consists Of 12 Companies, With Samples Obtained By The Purposive Sampling Method, So That 5 Companies Are Obtained For The Object Of The Research. The Research Results State That Inventory Management Has A Significant Influence On Profitability, While Debt Management And Receivables Management Do Not Show A Significant Influence On Profitability Or Cash Flow. In Addition, Cash Flow Does Not Work As A Significant Intervening Variable In The Relationship Between Debt, Receivable, And Inventory Management On Profitability. This Finding Indicates That Efficient Inventory Management Can Improve Cash Flow And, In Turn, Contribute To The Company's Profitability. However, Less-Off Debt And Receivable Management Can Hinder The Company's Profit Potential. This Research Provides Important Implications For Company Management In The Health Sub-Sector To Focus More On Inventory And Cash Flow Management To Improve Financial Performance. In Addition, The Results Of This Research Also Show The Need For A More Holistic Strategy In Financial Management, Which Does Not Only Focus On One Aspect, But Also Integrates Debt, Receivable, And Inventory Management Effectively. Thus, Companies Can Achieve Better And Sustainable Profitability In The Future.
Incidencia de la cultura tributaria en el Impuesto a la Renta de las Pymes del sector pesquero en Manta, 2023
Authors: Cevallos Pérez Eliana Lisbeth , Ubillús Macías Jessica Monserrate
Published: January 2025

La cultura tributaria, definida como las acciones en cuanto al cumplimiento de las obligaciones fiscales, es un tema de gran debate en Latinoamérica debido a la problemática existente en torno al comportamiento de los contribuyentes en relación a la declaración y pago de tributos. La investigación realizada aborda el análisis de la incidencia de la cultura tributaria en el impuesto a la renta de las pymes del sector pesquero de la ciudad de Manta. Para ello se aplicó una metodología investigativa de enfoque mixto, tipo explicativa, observacional, no experimental de corte transversal, tomando en consideración una muestra de 80 Pymes del sector pesquero de la ciudad de Manta, para el levantamiento de información se utilizaron técnicas de recolección de datos, como la entrevista y encuestas, procesándose los datos obtenidos con herramientas estadísticas. Lo cual permitió establecer la relación de una cultura tributaria con la declaración y pago del impuesto a la renta en empresas objeto de este estudio.
Coyote rescued from Aldi cold food section in great shape
Authors: Frey Erzsebet
Published: January 2025

A coyote was recently discovered in an unexpected place – the cold food section of an Aldi store. The wild animal was found in a surprisingly good condition given its unusual choice of location. The Unusual Discovery at Aldi Rescuing a coyote from an environment like a grocery store might sound surprising, but that’s precisely what happened. Imagine heading to your local Aldi, only to come across a wild coyote amidst the frozen food aisles.
II Zoogincana como estratégia de valorização da interdisciplinaridade
Authors: Oliveira Beatriz Dias , Sales Maria José Dias , Queiroz Magnólia Silva , Conceição Eltamara Souza da
Published: January 2025

A Zoogincana é um evento de extensão universitária anual promovido pelo curso de Licenciatura em Ciências Biológicas da Universidade do Estado da Bahia – campus II. Em sua segunda edição integrou ainda mais ações interdisciplinares de cursos do Departamento de Ciências Exatas e da Terra, como Ciências Biológicas e Matemática, e também do curso de mestrado em Modelagem e Simulação de Biossistemas (PPGMSB). Assim, o objetivo deste trabalho é fazer um relato de experiência sobre a II Zoogincana, descrevendo todos os aspectos – desde à concepção do evento até a avaliação dos resultados, reforçando a importância de atividades extensionistas, na perspectiva de valorizar a interdisciplinaridade, constituindo-se numa oportunidade de protagonismo estudantil. A realização do evento, desde sua concepção, foi pautada no protagonismo discente tanto nos aspectos acadêmicos (definição do tema, atividades a serem desenvolvidas, promoção da interdisciplinaridade) como nos aspectos logísticos (local, estandes, material audiovisual, patrocínio, entre outros), com participação de 57 estudantes do Ensino Superior. A Zoogincana envolveu de forma significativa estudantes da educação básica (anos finais do ensino fundamental e ensino médio) bem como a comunidade visitante com atividades lúdicas e interativas, incluindo jogos, brincadeiras, tarefas temáticas e exposições itinerantes dos laboratórios. Esse envolvimento foi crucial para o sucesso do evento, permitindo que os estudantes desenvolvessem habilidades de gestão, liderança e trabalho em equipe. O evento promoveu a Ciência e fortaleceu o papel da Universidade na formação cidadã, com a promoção de uma educação interdisciplinar, enfatizando a relevância das atividades extensionistas na formação acadêmica, essenciais para a formação integral dos futuros profissionais de diversas áreas.
The Yugoslav National Front: Attempt(s) to unify the Yugointegralists extreme right 1935-1939
Authors: Dragosavljević Vasilije
Published: January 2025

The idea of forming the Yugoslav National Front was the reaction of supporters of national and state unitarism to the gradual federalization of the first Yugoslav state initiated by the government of the Yugoslav Radical Union. The concept of a national front arose in the ranks of the senatorial club of the Yugoslav Radical Peasant Democracy party, and over time, other Yugoslav integralist political organizations accepted it - the Yugoslav People's Party, the YNM Zbor, and several political factions that arose in the process of the disintegration of Bogoljub Jevtić's political group. Contrary to the thesis put forward by socialist historiography that the leading cause of the failure of the concept of the Yugoslav National Front was the struggle for primacy between the leaders of the Yugoslav integralist parties, a detailed analysis shows us that behind the failure was the continuous work of the government of M. Stojadinović on preventing the unification of supporters of integral Yugoslavism. The radical methods used by the regime to achieve this goal (corruption, police repression, negative campaign in the media, construction of false affairs) eloquently testify to the political potential that the idea of gathering all supporters of national and state unitarism had and also to the danger that its implementation represented for the government of M. Stojadinović. There is a paradox in the fact that the concept of the Yugoslav National Front was ultimately implemented by Milan Stojadinović - a person against whose politics the idea itself was directed and who devoted most of the time he spent at the head of the Yugoslav government to the fight against the unification of the Yugoslav integralist forces. At the same time, this paradox (in addition to the instability of Stojadinović's political principles) clearly illustrates the role of the theory of integral Yugoslavism as the last line of defense for the integrity of the Yugoslav state in moments of crisis.
Addressing Socio-Economic Drivers of Management Style Evolution: Embracing Complexity Leadership Solutions
Authors: Nešić Tomašević , Sitarević Aleksandra , Marković Mirko , Ivetić Olga , Meško Maja , Qureshi Fayyaz
Published: January 2025

Background: The information age has ushered in a novel economic model known as the information economy, challenging traditional bureaucratic mechanisms that were primarily seen as tools to mitigate uncertainty. Within this context, complex leadership emerges as a paradigm that thrives on systemic interactions and intricate dynamics. Here, the onus lies on establishing the framework and conditions that empower the adaptive essence of leadership to flourish. Purpose: The aim of this research is to establish a framework for optimal leadership management, uncovering previously unexplored factors shaping employee work behavior. By identifying and defining key components within management mechanisms that greatly enhance employee performance, the objective is to cultivate rooted and effective management practices. Study design/methodology/approach: The research involved 480 respondents from diverse sociodemographic backgrounds and companies. Complexity leadership was assessed using the Complexity Leadership Scale, measuring Generative and Administrative leadership. Employee cooperation was evaluated with the Scala Supportive and Non-Controlling Supervision. Statistical methods included multiple regression, Pearson correlation, t-tests, and MANOVA. Findings/conclusions: The evaluation shows that both Generative and Administrative leadership are moderately expressed. Generative leadership positively correlates with Supportive and Non-Controlling Supervision, achieving statistically significant results. In contrast, Administrative leadership has negative correlations with these supervisory styles. Limitations/future research: The limitations of the research are of a methodological nature and refer to the sample of employees, according to demographic characteristics and company characteristics. Also, questionnaires based on self-assessment most often imply a certain number of socially desirable answers. Future research should include a larger sample to improve external validity and ensure that the empirical evidence obtained is variable across a range of organizational settings.
Biblioteca Electrónica Textual del teatro español (1868-1936) e investigación con grafos
Authors: Martínez Carro Elena , Santa María Fernández Teresa
Published: January 2025

Este artículo presenta, en primer lugar, el proceso de trabajo para la construcción de la Biblioteca Electrónica Textual del Teatro en Español (1868-1936) del Grupo de Humanidades y Edición Digital (GHEDI). Dentro de las decisiones y labores realizadas hasta la fecha encontramos: la elección de los autores, el proceso de trabajo de las obras que se han editado con lenguaje de marcado XML-TEI, la construcción de metadatos y la utilización posterior de grafos para el análisis de las piezas dramáticas. En segundo lugar, encontramos una reflexión sobre el valor del uso de los grafos y el alcance de los metadatos empleados, a partir del estudio de los grafos elaborados sobre dos obras: Electra de Benito Pérez Galdós y Luces de bohemia de Valle-Inclán.
REALIZED GENETIC GAIN AND SEED SOURCE X SITE INTERACTION ON STAND VOLUME PRODUCTIVITY OF ACACIA MANGIUM
Authors: Nirsatmanto Arif , Setyaji Teguh , Wahyuningtyas Reny Setyo
Published: January 2025

Following the results of the comprehensive tree improvement programs for Acacia mangium, it is necessary to estimate the real amount of genetic improvement and to develop an improved seed deployment strategy.  This study was aimed to verify realized genetic gain on stand volume productivity attained by the first-generation Seedling Seed Orchards (SSO) of A. mangium and to identify the magnitude of seed sources x site interaction as a basis for improved seed deployment. Seeds from five SSOs were tested together with seeds from seed stand in genetic gain trials which were established in South Kalimantan and Central Java. Realized gains were calculated from the percentage improvement of respective SSOs compared with seed stand at two and four years of age. Seed source x site interaction was investigated through analysis across the two sites.  Results of the study showed that trees derived from the five SSOs produced better stand volume than those from seed stand. At four years of age, stand volume of the best SSO reached around 127 m3/ha in South Kalimantan and 84 m3/ha in Central Java.  Realized genetic gain were around 66% at two years and 59% at four years in South Kalimantan, and around 136% at two years and 81% at four years in Central Java.  Seed source x site interaction was not significantly different indicating superiority of improved seed were consistent across the two sites with the average realized gain ranging from 18% to 79% and 24% to 62%  at two and four years, respectively.
THE EFFECT OF SILVICULTURAL TREATMENT ON STAND GROWTH OF LOGGED-OVER FOREST IN SOUTH PAPUA
Authors: Kuswandi Relawan
Published: January 2025

Forest stand structure could be used as one of  the variables in deciding the possibility to harvest forest product. On logged-over forests, data and information over stand structure could become the basis for decision making for harvesting. To measure and analyze yield on logged-over forest, each forest management unit (IUPHHK) is obligated to establish Permanent Sample Plots (PSPs) for monitoring the growth and yield of  the managed stand. In some of  the plots, maintenances and thinning treatments are applied while other plots are not treated.  The results, after several years of  observations, showed that there was a difference in stand structure (tree number) of  each diameter class both in plots with treatment and without treatment. The rate of  in-growth, up-growth and mortality varied between plots without and with treatment in each diameter class and length of  time after harvesting. The average diameter increment of  trees in the stands of  the untreated plots was higher (0.60 cm yr-1) compared to the treated plots (0.55 cm yr-1).
KARO’S LOCAL WISDOM: THE USE OF WOODY PLANTS FOR TRADITIONAL DIABETIC MEDICINES
Authors: Situmorang Rospita Odorlina , Harianja Alfonsus H. , Silalahi Johansen
Published: January 2025

This paper identifies the plant species used  traditionally by Karo people in North Sumatra, to cure diabetes, analyses the cultural significance index of  those plants for the Karo, and clarifies phytochemical contents of  the plants. Data were collected using survey method from selected respondents (n=54) based on their knowledge and practices in utilising medicinal plants to cure diabetic disease. Index of  Cultural Significance (ICS) of  plants was determined using the method proposed by Turner. Results showed that twelve woody plant species have been used to cure diabetes: loning leave (Psychotria sp.), kacihe leave (Prunus accuminta Hook), umbrella tree leave (Maesopsis eminii Engl), mutamba leave (Guazuma ulmifolia Lamk), cepcepan leave (Villebrunea subescens Blume), pirdot/cepcepan lembu leave (Saurauia vulcani Korth), raru bark (Cotylelobium melanoxylo), breadfruit leave (Artocarpus altilis), salam leave (Syzygium polyanthum Wight), mahogany seed (Swietenia mahagoni (L.) Jacq), cinnamon bark (Cinnamomum burmani), and yellow bamboo rod (Bambusa vulgaris Schrad). Five of  those plants: loning, umbrella tree, mutamba, raru and salam have the highest cultural significance level. These five plants are highly needed in large quatities by the Karo people, so their availability in the forest should be securely conserved and protected. The plants used contained alkaloids, flavonoids, phenolics and terpenoids which can help to lower blood sugar level.
UTILIZATION OF AREN (Arenga pinnata Merr.) SAWMILLING WASTE FOR EDIBLE MUSHROOM CULTIVATION MEDIA
Authors: Djarwanto Djarwanto , Suprapti Sihati
Published: January 2025

Aren (Arenga pinnata Merr.) is a multipurpose tree that can be utilized for palm sugar, alcoholic drinks, beverages and construction wood. The use of  aren sawdust has not been studied intensively. This study examines the utilization of  aren sawdust as cultivation media for edible mushrooms. Aren sawdust was mixed with rice bran, CaCO3, gypsum, fertilizers and distilled water before sterilization in 30 minutes pressurized autoclave at 1210C and 1.5atm. The mixed media was inoculated with pure cultures containing four mushrooms species (Pleurotus flabellatus, P. ostreatus, P. sajor-caju and Lentinula edodes) and incubated for five weeks to allow mycelium growth producing fruit bodies. The fruit bodies were harvested everyday within four months and examined for its gained mushroom-weight and biological conversion efficiency/BE. The core part of  aren trunk was cut into smaller pieces of  10 cm (width) by 5 cm (thickness), by 120 cm (length). Each core sample was bored from the surface inward, creating holes with a particular distance apart. Each hole was inoculated with pure cultures containing 6 mushroom species (four species above, P. cystidiosus and Auricularia polytricha). The inoculated samples were slanted on bamboo support, and placed in a bamboo hut. Harvesting was carried out everyday after the fruiting body became mature and examined for its gained mushroom weight. Results show that the use of  sawdust supplemented with nutritious material is more likely to improve the mushroom yield than that of  aren sawn-timber core.
DEVELOPMENT OF LOCAL ALLOMETRIC EQUATION TO ESTIMATE TOTAL ABOVEGROUND BIOMASS IN PAPUA TROPICAL FOREST
Authors: Maulana Sandhi I. , Wibisono Yohannes , Utomo Singgih
Published: January 2025

Recently, pantropical allometric equations have been commonly used across the globe to estimate the aboveground biomass of the forests, including in Indonesia. However, in relation to regional differences in diameter, height and wood density, the lack of data measured, particularly from eastern part of Indonesia, may raise the question on accuracy of pantropical allometric in such area. Hence, this paper examines the differences of local allometric equations of Papua Island with equations developed by Chave and his research groups. Measurements of biomass in this study were conducted directly based on weighing and destructive samplings. Results show that the most appropriate local equation to estimate total aboveground biomass in Papua tropical forest is Log(TAGB) = -0.267 + 2.23 Log(DBH) +0.649 Log(WD) (CF=1.013; VIF=1.6; R2= 95%; R2-adj= 95.1%; RMSE= 0.149; P<0.001). This equation is also a better option in comparison to those of previously published pantropical equations with only 6.47% average deviation and 5.37 points of relative bias. This finding implies that the locally developed equation should be a better option to produce more accurate site specific total aboveground biomass estimation.
Designing from HeritageStrategies for Conservation and Conversion
Authors:   Delft University of Technology, Kuipers Marieke , de Jonge Wessel ,   Delft University of Technology
Published: January 2025

Designing from Heritage deals with challenges architects are faced with when dealing with the conservation and reuse of built heritage, with a focus on Modern Movement Monuments. It discusses how to carry out a thorough analysis and evaluation of monuments upon which their conservation and transformation can be based. It is meant for MSc education, but may be of interest to architects in general.

This book — the third in the Rondeltappe series — reflects the philosophy and didactic approach of Heritage and Architecture (H&A) section of the Faculty of Architecture and the Built Environment (Delft University of Technology). H&A has three chairs: Design, Cultural Value and Technology. They work in close cooperation to lay the foundations for the preservation and continuity of use of built heritage.

Designing from Heritage is strongly connected to the first book in the Rondeltappe series which deals with durability and sustainability of monuments, and with the second which advocates freedom in heritage based design. It contains the contribution of Prof. Wessel de Jonge — the Chair of Heritage and Design and principle at Wessel de Jonge Architects — and Prof Marieke Kuipers — Chair of Culural Heritage in particular of the Architecture of the Twentieth Century and senior specialist of Twentieth Century Built Heritage at the Cultural Heritage Agency of the Netherlands (RCE).

Designing from Heritage is subdivided in four chapters:

The first, a contribution by Wessel de Jonge, sketches issues of transitoriness and timelessness related to the reuse of Modern Movement monuments. Their values, characteristics and potentials are the foundations for architectural design aimed at guaranteeing their future lives.
In the second chapter, Marieke Kuipers presents a didactic exercise in critical observation of the architectural object.
In the third, she discusses the interpretation of tangible and intangible heritage values in order to specify the main characteristics and critical issues in relation to continuity and change.
Finally, Wessel de Jonge presents his experience of the role of the architect in relation to heritage value assessment, with specific reference to the conservation of Modern Movement monuments.
This book is part of a series of books produced in cooperation with and financed by the Stichting Rondeltappe-Bernoster-Kemmers. All books of the series have been reviewed and edited by Silvia Naldini, Section of Heritage & Architecture, Faculty of Architecture and the Built Environment, Delft University of Technology, The Netherlands.
IMPROVING SURGICAL RESULTS: AN ESSENTIAL REVIEW OF ORTHOPAEDIC SURGERY ANTIBIOTIC PROPHYLACTIC STRATEGIES
Authors:   Department of Pharmacy Practice, NIMS University Rajasthan, Jaipur, India., Raj Shobhit
Published: January 2025

The likelihood of extended hospitalisation, increased healthcare expenses, and patient suffering resulting from post-orthopaedic surgical site infections (SSIs) means that the postoperative burden is still somewhat heavy. These diseases also provide a great difficulty for orthopaedic surgeons. Along with higher rates of morbidity and death, post-orthopaedic SSIs have been linked to increased sensitivity to negative health consequences. SAP, or systemic antibiotic prophylactic therapy, lowers the SSI risk. Different characteristics of closed fractures, open fractures, arthroplasty, and percutaneous fixation affect the data and antimicrobial treatment. Implementing SAP requires careful balancing of good antibiotic stewardship practices with reducing the occurrence of SSIs. This approach essentially stops antibiotic resistance from developing as well as the frequency of unpleasant effects. The aim of this study was to investigate the present body of knowledge on the use of surgical antibiotic prophylaxis in orthopaedic surgery and investigate the possible effects connected with the improper dosage of antibiotics.
DECODING DIFFERENCES: EXPLORING THE DIVERGENCE OF RHEUMATOID ARTHRITIS & ANKYLOSING SPONDYLITIS
Authors:   Department of Pharmacy Practice, ISF College of Pharmacy, Moga., Dhindsa Jessica
Published: January 2025

Objective: This review article presents a comprehensive overview of the distinctions between two enduring autoimmune disorders: Rheumatoid arthritis (RA) and Ankyliosing spondylitis (AS), both of which affect the musculoskeletal system. The article highlights the differences in clinical manifestations, underlying mechanisms, and treatment approaches for these conditions. Methodology: This study is conducted by reviewing on google scholar using keywords such as RA and AS. Discussion: The article emphasizes that the key differences between these conditions lie in the affected body areas, genetic predisposition, and joint involvement. While RA mainly affects peripheral joints with inflammation of synovial tissues, AS primarily impacts the axial skeleton, leading to the fusion of spinal structures. RA has a strong autoimmune component, whereas AS is linked to HLA-B27. Treatment strategies differ, with RA benefiting from DMARDs and biologics, while AS relies on NSAIDs and TNF inhibitors. Understanding these distinctions is vital for accurate diagnosis and effective treatment planning. A patient’s quality of life may be significantly impacted by either of disease, underscoring the importance of early intervention and a multidisciplinary approach. Tailoring management to individual patient needs, considering factors like disease severity, comorbidities, and patient preferences, is essential. Regular monitoring, physical therapy, and lifestyle adjustments play crucial roles in managing these chronic conditions.
A CASE REPORT OF FULL THICKNESS DERMAL DEHISCENCE IN STRIAE GRAVIDARUM
Authors:   Department of Obstetrics and Gynaecology, Mahaveer Institute of Medical Sciences and research, Bhopal, Madhya Pradesh, India., Chhari Anjali
Published: January 2025

Striae gravidarum are atrophic linear scars that represents one of the most common connective tissue changes of pregnancy. In most cases it heals on its own after leaving scar invariably. This unique case was encountered with atypical presentation of Striae Gravidarum showing full thickness dehiscence and ulcerative lesion on the striae gravidarum .The patient delivered vaginally and the lesions showed spontaneous healing post delivery.
NEUROPROTECTIVE EFFECTS OF CITRULLUS COLOCYNTHIS ETHANOLIC EXTRACT IN A 6-OHDA-INDUCED RAT MODEL OF PARKINSON'S DISEASE
Authors:   Research Scholar, Department of pharmacology, ADINA Institute of pharmaceutical Sciences, Sagar, 470001 Madhya Pradesh, India, Kaushik Dhananjay
Published: January 2025

Parkinson's disease (PD), a prevalent neurological disorder, is marked by the degeneration of dopamineproducing neurons. In this study, a Wistar rat model of PD induced by 6-hydroxydopamine (6-OHDA) was used to investigate the potential neuroprotective effects of an ethanolic extract of Citrullus colocynthis. The rats were injected with 6-OHDA using a Hamilton syringe and stereotaxic equipment to mimic Parkinsonism. After a 30-day post-surgery survival period, the rats received an oral dose of 200 mg/kg of the Citrullus colocynthis extract, which was prepared using a Soxhlet device with a 70:30 ethanol-to-water solvent ratio. The rats also underwent step-testing exercises. For comparison, a group received conventional therapy with 5 mg/kg of L-dopa+carbidopa. The efficacy of the treatment was evaluated based on tremor, salivation, and performance in pole tests, open field tests, and rotarod tests. The findings suggest that Citrullus colocynthis may possess significant neuroprotective properties, making it a promising adjunctive therapy for Parkinson's disease.