bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of Meat Post-Harvest Technology By The Housewife Group In Kendari City
Authors: Patriani Peni patriani
Published: January 2023

Community service aims to provide a comprehensive understanding for the housewife group in Gunungjati Sub-District around Kendari City Market regarding the management of healthy food and livestock products. This activity is expected to provide knowledge and skills related to fresh meat and its processing to obtain food diversification, increase nutritional value, longer shelf life, and added economic value. The method used was training and direct demonstration related to fresh, preserved, and rotten meat as well as the processing of nuggets and sausage. Various meats can be used to make nuggets and sausages such as chicken, beef and buffalo meat. Training materials were related to the importance of consuming fresh meat, the importance of choosing uncontaminated meat with preservatives, and processed livestock products in the form of nuggets and sausages with benefits for human health and can be a source of family income. This activity has a positive impact to make people creative with meat-based ingredients and motivates them to create a business field. The types of meat that have been used for the development of sausage and nugget products are beef, rejected chicken meat and broiler chicken meat
The Survival of Patients with Triple Negative Breast Cancer Undergoing Chemotherapy Along with Lifestyle Change Interventions
Authors: Aznab Mozaffar , Shojae Shahram , Golpazir Sorkheh Arash , Eslam pia Kiumars , Rezaei Mansour
Published: January 2023

Background: The survival of patients with triple-negative breast cancer subtype undergoing chemotherapy along with weight management, physical activity, and diet was examined. In addition, the relationship between the Overall Survival (OS) of patients with expression P53 and Ki 67 was investigated. 
Methods: The study was conducted on 110 patients admitted to oncology clinics between October 2009 and July 2018. The patients underwent five chemotherapy cycles, including Docetaxel, Epirubicin, and Cyclophosphamide once every 21 days followed by two cycles of Epirubicin, Cyclophosphamide, and 5-Fluorouracil. The patients also received guidelines for physical exercise, diet, and lifestyle change.
Results: The median and mean follow-ups were 52.3 and 45.6 months respectively. Eight patients were metastatic and 103 were under adjuvant therapy, 13 of whom had relapses. The median relapse-free survival and mean OS were 44.4 months and 49.2 months respectively. OS for P53-negative patients was 64.2 months, eight patients relapsed in the P53-positive group, and two relapsed in the P53-negative group. Survival was more favorable in the negative group (P=0.021). The mean DFS in the P53- negative group was 96.1% and 76.3% in the P53-positive group, suggesting a more favorable status in the P53-negative group. Out of 110 patients, 20 died and 90 are still alive.
Conclusion: Combining physical exercise, diet, and lifestyle change with chemotherapy increases the chance of a better response to treatment and a reduction in the rate of relapse during the first three years. The survival rate was better in p53-negative patients.
Breeching “The Goldilocks Zone”: Tetraplegia as a Rare Life-Altering Infective Complication of Adjuvant Breast Cancer Chemotherapy
Authors: Broderick Aoife , Carroll Hailey Kathryn , O'Riordan Kenneth , Jackson Arthur , Macfarlane John , O'Reilly Seamus
Published: January 2023

Background: Adjuvant chemotherapy has been an integral component of breast cancer care for decades. Advances in supportive care have been made, but despite this, infective complications of therapy remain a significant toxicity concern.
Case Presentation: A premenopausal patient presented to the emergency department during the third wave of the Covid-19 pandemic with sepsis after a second course of adjuvant docetaxel-cyclophosphamide chemotherapy. Overnight she developed tetraplegia. An urgent MRI cervical spine revealed a pre-vertebral, vertebral, and epidural abscess. This was treated with an emergency C4-C7 posterior cervical laminectomy and decompression. Her inpatient care involved a protracted ICU admission followed by rehabilitation. She remains tetraplegic and requires continued inpatient care over a year after presentation. Restricted pandemic-related hospital visiting has compounded the impact of her illness.
Conclusion: Infective complications of adjuvant breast cancer chemotherapy remain an issue despite advances in supportive care. This case highlights the devastating, life-altering impact that these complications can have as emphasized by the inclusion of the patient’s perspective.
HUBUNGAN SIKLUS MENSTRUASI DENGAN KEJADIAN ANEMIA REMAJA PUTRI DI SMP NEGERI 2 KERAMBITAN KABUPATEN TABANAN
Authors: Nofianti I.G.A.T.P. , Juliasih N. K. , Wahyudi I.W.G.
Published: January 2023

Remaja putri lebih rentan terkena anemia dibandingkan dengan remaja putra, karena remaja putri mengalami menstruasi setiap bulannya. Siklus menstruasi ini  merupakan salah satu faktor penyebab remaja putri mudah terkena anemia defisiensi zat besi. Tujuan penelitian ini adalah untuk mengetahui hubungan siklus menstruasi dengan kejadian anemia remaja putri di SMP Negeri 2 Kerambitan Kabupaten Tabanan. Penelitian ini menggunakan metode  observasional analitik dengan pendekatan cross sectional. Populasi dari penelitian ini adalah remaja putri SMP Negeri 2 Kerambitan berjumlah 290 siswi. Sampel penelitian berjumlah 89 responden  yang telah memenuhi kriteria inklusi dan eksklusi. Analisis yang digunakan univariat dan bivariat dengan menggunakan uji chi square. Responden yang mengalami anemia sebesar 47 responden (52,8%) dan tidak mengalami anemia sebesar 42 responden (47,2%). Sedangkan responden yang mengalami siklus menstruasi tidak normal sebesar 44 responden (49,4%) dan yang mengalami siklus menstruasi normal sebesar 45 responden (50,6%).   Hasil penelitiaan membuktikan ada hubungan hubungan antara siklus menstruasi dengan kejadian anemia pada remaja putri di SMP Negeri 2 Kerambitan Kabupaten Tabanan dengan nilai p = 0,001.
DAYA HAMBAT MADU LEBAH KLANCENG (Trigona laeviceps) TERHADAP PERTUMBUHAN BAKTERI Escherichia coli
Authors: Astawa I K. P , Arsana I N. , Wahyudi I W.
Published: January 2023

Madu lebah klanceng memiliki banyak manfaat diberbagai aspek seperti kesehatan, kecantikan dan pangan. Madu sebagai antibakteri tidak terlepas dari kandungan zat aktif yang ada didalamnya seperti hidrogen peroksida, senyawa flavonoid, minyak atsiri, dan berbagai senyawa organik lainnya. Penelitian ini bertujuan untuk mengetahui daya hambat madu lebah klanceng terhadap pertumbuhan bakteri Escherichia coli yang dilaksanakan dari bulan April – Juni 2018 di Laboratorium Mikrobiologi Fakultas Kedokteran dan Laboratorium Mikrobiologi Pangan Fakultas Teknologi Pangan Universitas Udayana. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dan metode yang digunakan adalah uji sensitivitas bakteri dengan disk yang dibagi menjadi tujuh kelompok perlakuan konsentrasi madu lebah klanceng yaitu konsentrasi 15%, 30%, 45%, 60%, 75%, 90% dan 100% serta dua kelompok kontrol sebagai pembanding yaitu kontrol negatif (aquadest) dan kontrol positif (meropenem). Hasil penelitian menunjukkan bahwa madu lebah klanceng dapat menghambat pertumbuhan bakteri Escherichia coli dengan rerata daya hambat pada konsentrasi 15% (6 mm); 30% (6,33 mm); 45% (7,67 mm); 60% (9 mm); 75% (9,67 mm); 90% (11 mm); dan 100% (11,67 mm). Semakin tinggi konsentrasi madu lebah klanceng, maka semakin besar daya hambat terhadap pertumbuhan bakteri Escherichia coli. Hal tersebut diperkuat berdasarkan uji analisis Kruskal-Wallis yang dilanjutkan dengan post hoc U Mann-Whitney terdapat perbedaan yang signifikan antara masing-masing variasi konsentrasi madu lebah klanceng dengan nilai p=0,001 (p<0,05).
PROSES FERMENTASI TERHADAP PENGOLAHAN KAKAO MENJADI PRODUK BAHAN PANGAN
Authors: Widyantari Anak Agung Ayu Sauca Sunia
Published: January 2023

Tanaman kakao merupakan tanaman yang berbunga dan berbuah sepanjang tahun dan menjadi penyumbang devisa bagi Negara. Kakao tumbuh di Indonesia cukup melimpah. Pemanfaatan tumbuhan kakao bisa digunakan untuk berbagai macam jenis pangan makanan  dan  minuman karena semua bagian dari kakao bisa digunakan.  Dalam Proses pengolahan kakao menjadi bahan pangan sangat tergantung pada sifat fisik dan kimia serta pada saat proses fermentasi. proses fermantasi pada biji kakao akan mepengaruhi kualitas dari produk yang dihasilkan dari pengolahan tanaman kakao.
PERANAN KELUARGA MENCIPTAKAN LINGKUNGAN SEHAT BAGI ANAK
Authors: Yadnyawati Ida Ayu Gde , Sri Winarti Ni Nyoman , Seniwati Desak , Ayu Ngurah I Gusti , Surawati Ni Made
Published: January 2023

Ruang yang ditempati suatu makhluk hidup bersama dengan  benda hidup dan tak hidup di dalamnya disebut lingkungan hidup makhluk tersebut. Lingkungan merupakan kesatuan ruang dengan semua benda, daya, keadaan dan makhluk hidup termasuk manusia dan perilakunya yang mempengaruhi alam, kelangsungan perikehidupan. Lingkungan adalah keadaan sekitar yang mempengaruhi perkembangan dan tingkah laku makhluk hidup.  Keluarga menjadi agen utama yang memiliki tugas dan fungsi meneruskan kebiasaan,sikap, perilaku dan nilai-nilai dengan menciptakan sebuah kondisi yang kondusif agar tercipta interaksi dan sosialisasi yang positif antara individu anak dengan lingkungan. Peran orang tua dalam keluarga menjadi penting dalam mengasuh, membimbing dan membentuk kepribadian anak. Dalam hal ini pendidikan lingkungan juga harus ditanamkan. Lingkungan yang sehat cocok untuk dijadikan arena bermain anak atau tempat tinggal anak. Jika lingkungan rumah tidak sehat, hal itu bisa mempengaruhi kesehatan anak dan berpengaruh terhadap tumbuh kembang anak. Diperlukan usaha dan upaya agar bisa menciptakan lingkungan yang sehat. Peranan keluarga sangat penting dalam menciptakan lingkungan yang sehat.
GREEN INVOLVEMENT, WORKPLACE WELL-BEING, AND CAREER PLANNING AFFECT TURNOVER INTENTION; IS IT POSSIBLE?
Authors: Arfari Abyan , Oki Berlyanti Dita , Robiatul Adawiyah Wiwik
Published: January 2023

The research method used in this research is quantitative descriptive, involving 1 dependent variable and 3 independent variables; the independent variables are Green Involvement, Workplace Well Being, and Career Planning, while the dependent variable is Turnover Intention. The results of the data analysis show that green involvement has a positive influence on turnover intentions. This can be seen based on a significance value of.007 0.05, which indicates that H 0 is rejected, H a is supported with a value () of.278. Workplace well-being has a positive influence on turnover intention. This can be seen based on a significance value of.194 0.05, which indicates that H0 is rejected, Ha is supported with a value () of.091, and career planning has a positive influence on turnover intention. This is evident from the significance value of.000 0.05, indicating that H 0 is rejected and H a is supported by a value () of.710. The conclusion of this research is that employees agree with the implementation of green engagement, wellbeing at work, and career planning to reduce high levels of transfer intentions.
EFEKTIFITAS KONSELING TEMAN SEBAYA UNTUK MEREDUKSI KECANDUAN GAME ONLINE PADA REMAJA DI JORONG SUNGAI JARIANG KANAGARIAN KOTO PANJANG KECAMATAN IV KOTO KABUPATEN AGAM
Authors: Khairani Widya , Yusri Fadhilla
Published: January 2023

Tujuan yang akan dicapai dalam penelitian ini adalah untuk melihat efektifitas konseling teman sebaya untuk mereduksi kecanduan game online di Jorong Sungai Jariang Kanagarian Koto Panjang Kecamatan IV Koto Kabupaten Agam. Jenis penelitian yang penulis lakukan adalah jenis penelitian lapangan dengan mengunakan metode penelitian pre- eksperimen, yang merupakan jenis penelitian eksperimen yang masih terdapat variabel luar yang berpengaruh terhadap terbentuknya variabel dependen. Penelitian menggunakan jenis penelitin one group pre test post test design.sampel dalam penelitian ini adalah remaja yang berusisa 15-18 tahun yang berada di Jorong Sungai Jariang.Teknik yang dipakai dalam pengambilan sampel adalah teknik purpose sampling dimana pengambilan sampl berdasarkan pertimbangan pertimbangan tertentu. Teknik analisis data menggunakan uji normalitas, uji homogenitas, uji hipotesis menggunakan SPSS versi 25. Berdasarkan hasil penelitian yang  dilihat dari pretest dan posttest dengan mngunakan uji t yang dilakukan dengan menggunakan program SPSS 25. Berdasarkan hasil analisa data menggunakan uji t diketahui nilai sig (2-taliled) adalah sebesar 0,000. Dengan hal ini dibuktikan hasil sig (2-tailed) 0,000˂ 0,05. Pernyataan ini juga berdasarkan t hitung 2,679. Nilai t hitung adalah nilai mutlak. Jika nilai t hitung sebesar 1.679 ˃ t table 1,161 dengan df 14 pada taraf significance 0,05 maka dapat dikatakan Ha diterima artinya terdapat perbedaan antara lain pretest dan posttest setelah diberikan layanan konseling teman sebaya dan Ho ditolak. jadi dapat disimpulkan bahwa konseling teman sebaya sangat berpengaruh secara significance dalam mereduksi kecanduan game online pada remaja di Jorong Sungai Jariang
Amalan Kualiti dan Hubungan Gaya Kepimpinan Terhadap Elemen Soft dan Hard Model McKinsey
Authors: Taib Che Azlan , Ahmad Azhar , Abu Noor Hidayah
Published: January 2023

Public Service Transformation Framework (PSTF) developed based on the principles andplatform of integrity of governance, patriotism, values, corporate ethics and integrity,eco-system and environment of harmonious civil service, included an advance of scienceand technology. PSTF was supported with five strategic thrusts namely empower talent,organizational re-engineering, populist service delivery, embrance and belonging andentrenched values. Hence, government agencies have a great responsibility for ensuring itbecome reality and a comprehensive instrument should be performed. As such, this studypresents the basic formation of the framework and the formulation of strategic towardsachieving the transformation. Seven dimensions of McKinsey 7S model has been used torecognize the strengths and weaknesses of the organization. An adapted set ofquestionnaire from McKinsey 7S model was developed to collecet the data. It comprises44 items: 9 items for SYSTEM, 8 items for STAF, each 6 items for STRATEGIC,STRUCTURE and STYLE, 5 items for SHARE VALUE and 4 items to SKILLS. A total of273 respondents were involved and the realibility test is used to confirm the instrumentthrough 3 criterias i.e. Coefficient Alpha (CA), Corrected Item-Total Correlation (CITC)and Alpha If Item Deleted (AIID). Analysis found that all dimensions were met thecriteria, except STRATEGIC element which is an average score is above 70%. Therelationship of correlation indicated all dimensions are significant at the p < 0.001. Thestudy also shows a significant relationship exists between KEMPIMPINAN STYLE withSOFT and HARD elements.
Managing Social and Economic Performance in Social Enterprise
Authors: Abdul Zalim Siti Nazariah , Abdul Khalid Siti Nabiha , Azhar Zubir
Published: January 2023

Social enterprise encounter has received enormous pressure to manage both social andeconomic objectives. This has given rise to tension in managing social and economicobjectives leading to tension within the organisation. Failure to manage this tension andcompeting demands between these two objectives raise concerns toward mission driftissue. The paper discusses the conceptualisation of social enterprise and its competingdemands, and the analysis of normative and empirical research on performancemeasurement system (PMS) and management control in social enterprise. From thenormative literature, a number PMS models for social enterprise were advanced.However, there is lack of empirical research on management control and performancemeasurement in social enterprise, especially regarding the ways an organisationdesigns and uses its PMS to achieve a balance between social and economic objectives.Hence, a qualitative method is recommended as a developing strategy for managing thecompeting demands since they are very much dependent on the manner organisationalview and deal with the needs of the two objectives.
Factors Influencing Sertu Cleansing Integrity in Halal Logistics
Authors: Ahmad Noorsiah , Mohd Shariff Sariwati
Published: January 2023

Nowadays, the integrity of halal product status is important for Muslim consumers.Sertu cleansing operations is to ensure that transportation and logistics carrying halalproducts are assured with no occurrence of contamination from non-halal sources inhalal logistics. However, the study on sertu cleansing in Malaysia is still low. Therefore,this concept paper attempts to discuss factors in sertu cleansing integrity as stated inMalaysian Standards MS1500: 2009 for halal food production, preparing, handling,and storage, and MS2400: 2010 for halalan-toiyibban assurance pipeline or known ashalal supply chain management. The factors in halal cleansing that influence the halalproduct integrity such as: sertu procedure; process or method of sertu cleansing; peopleengaged in these activities; and the sertu cleansing products. This paper generatesawareness and provides better understanding on the factors influencing sertu cleansingin assuring halal integrity of halal food products and other related products.
The Influence of Institutional and Contingency Factors on the Adoption of Forensic Accounting by Anti-Corruption Agencies: A Proposed Framework
Authors: Umar Ibrahim , Samsudin Rose Shamsiah , Mohamed Mudzamir
Published: January 2023

The increasing concern over corruption in developing countries has been associated with the inability of Anti-Corruption Agencies (ACAs) to tackle corruption. The ineffectiveness of these ACAs is said to be influenced by several factors including the underutilization of forensic accounting in fraud investigation process. This article focuses on the identification of these factors and their influences on the adoption of forensic accounting by ACAs. This was done through the review of literature and proposing a framework for further in-depth research work. The conceptual framework highlights the antecedent influence of political will on these factors and their influences on the adoption of forensic accounting. The implication is that identifying these factors through further in-depth studies will contribute to the insufficient research work on the adoption of forensic accounting and help policy makers to enhance the performance of these agencies.
Cartographic Analysis of the Construction of
Fabricius' Map of Moravia (1569)
Authors: Chrást Josef , Stachoň Zdeněk
Published: January 2023

The map of Moravia (1569) by the renowned Vienna scholar, Paulus Fabricius (ca. 1528-1589), is still considered to be the oldest known cartographic representation of Moravia. This paper focuses on the cartographic analysis of the map with the aim to identify possible methods of its construction with regard to some known circumstances of its origin. The author of the map mentions in the appended texts that he travelled through Moravia several times. The methodology of the work is based on selected spatial analyses of the positional and height aspects of displayed settlements. The achieved results are compared and discussed in the context of other information sources, especially the existing settlement structure and contemporary communication network. The conclusions reveal a correlation between the density of the depicted settlements and the proximity of a modelled communication network. The orographic conditions of Moravia have a significant influence on the map content. The plains are covered in detail, hilly lands and highlands are rarely and randomly mapped, whereas the mountains are not described at all. In the peripheral parts of the area of interest, the author probably worked only with data from travel itineraries. With regard to achieved results, it can be assumed that there is potential to apply the established procedures to the analysis of old maps of similar type. Unlike later maps, they are based on the author's travelling experiences and impressions, rather than on complex measurements of geographical coordinates.
Negotiated and Involuntary Return: COVID-19 Pandemic and Return Migration of Bangladeshi Temporary Labour Migrant Men
Authors: Islam Md. Mohaiminul
Published: January 2023

This paper investigates return migration of Bangladeshi temporary labour migrant men in the midst of the COVID-19 pandemic. Drawing on a case study of Bangladeshi migrants, who are mostly occupied in low and semi-skilled labour-intensive markets in the Middle East and the Southeast Asian countries, this paper assesses the relational aspect between pandemic and return. It discusses the underlying reasons of pandemic induced return which is based on a fieldwork, conducted in 2021, with the Bangladeshi returnee migrants. It argues that migrant receiving states' exploitative policies–burgeoning labour market nationalisation and lack of social and legal protection mechanisms–are the overriding reasons of return, rather than the pandemic. Whilst the pandemic intensified these existing exclusionary policies, this paper depicts how the migrants conform to the policies of migrant receiving states through rigid visa regime, heightened labour market immobility, retrenchment, and wage theft, which resulted in return migration.
From Religious to Ethnic Minorities: The Cultural and Social Integration of Pomaks into Post-Ottoman Turkey
Authors: Emen-Gökatalay Gözde
Published: January 2023

This article traces the cultural and social integration of Pomaks into post-Ottoman Turkey and the controversy over their ‘Turkishness’. Current scholarship on early republican nationalism is particularly interested in the importance of the imperial legacy in nation-building in the early republic period. Scholars discuss that the Ottoman legacy of the millet system was vital to the formation of Turkish identity because the republican elites continued to accept Muslim immigrants from the Balkans due to their Islamic background. A closer analysis of primary sources with a focus on Pomak-speaking immigrants, however, reveals not only the challenges that their cultural assimilation posed for the government but also competing versions of Turkishness within intellectual and political circles. This article argues for a complex understanding of relations between immigration and nationalism, which shows that the public acceptance of Pomaks as Turks depended on domestic factors, such as linguistic nationalism and security concerns.
Methamphetamine-induced widespread oral ulcerations
Authors: SALICI Nazmiye Selin , RASULOVA Gunel , BÜYÜKBABANİ Nesimi , YAYLI Savaş
Published: January 2023

3,4-methylenedioxymethamphetamine (MDMA), known as ecstasy, is a hallucinogen and stimulant illicit drug. Besides the systemic effects of this drug are well documented, it can also present with a range of oral side effects such as ulcerations, and to our knowledge, there are only a few cases involving oral mucosal ulcerations related to MDMA abuse in the literature. We encountered a 38-year-old man with widespread and multiple oral ulcerations attributed to MDMA abuse.
We would like to raise awareness about that this kind of ulcers may be associated with ecstasy use, and it should be included in the differential diagnosis.
Stixis suaveolens (Roxb.) Fruit Extract Deciphered Antidepressant and Antidiarrheal Effects via In vivo Approach
Authors: Islam Md Monirul , Hossain Md Jamal , Zahan Miss Sharmin , Nur Farjahan , Al Mansur Muhammad Abdullah , Rashid Mohammad A
Published: January 2023

Depression is a pervasive psychiatric disorder worldwide and diarrhea is considered a leading cause of preventable death for infants and children in developing countries. The current study was done to assess in vivo activities of crude methanol extract of Stixis suaveolens fruit, focusing on antidepressant and antidiarrheal effects. The effect on central nervous system (CNS) was examined by recording the onset of sleep and total sleeping time. Besides, castor oil-induced diarrhea in the mice model was followed while evaluating the antidiarrheal effects. Significant (p<0.01) reduction in onset time (64.8 min) as well as in total sleeping time (64.8 min) were recorded between the test groups and the control. The extract, when given orally, also resulted in a significant (p < 0.001) reduction of diarrheal feces induced by castor oil by 71.43%. The in vivo bioassays demonstrated that the crude methanol extract of the fruit of S. suaveolens contains significant antidiarrheal and CNS stimulating actions. However, further vigorous studies are recommended to isolate and characterize the major phytoconstituents from the plant in order to develop the exact mechanism of actions of the plant against various disorders.
Bangladesh Pharmaceutical Journal 26(1): 28-35, 2023 (January)
New Indications & Dosage Forms for Existing Drugs Vol. 26(1)
Authors: Rashid Md Abdur
Published: January 2023

Abstract not available
Bangladesh Pharmaceutical Journal 26(1): 114-118, 2023 (January)
Relation of the Trauma Symptom Inventory’s Sexual Dysfunction Subscale to Overall Distress in African American College Students
Authors: Reed Michael K , Rucker Reginald , LeSueur-Reed Kolitta , Hicks Shelby , Toussaint Jordan , Ramirez-Tolentino Damaris , Bolton Princess , Kang Glory , Lesesne Isaiah
Published: January 2023

Recent research has identified that traumatic events have affected individuals from all occupations. Severe trauma and reactions, which in the past were primarily identified with military veterans, have now been recognized in people throughout society. The TSI-2 is a 136 item self-report tool that examines the impact of trauma on an individual’s social and interpersonal functioning. The test has 4 global scales and 12 subscales. This study examined the relation of the Sexual Dysfunction subscale to overall pathology and its implication in African American college students. Students from a HBCU volunteered to complete this scale as part of a larger study-evaluating mood and cognitive functioning. The researchers reexamined the data in relation to performance on the Sexual Dysfunction Scale and overall signs of distress, depression and anxiety. Results found individuals who scored elevated on the scale also had high elevations on measures of significant distress and pathology. They also were high risks for selfinjury. An item analysis indicated these individuals were likely to act impulsively and demonstrate acknowledged poor judgment in dating and sexual activities (e.g., having sex without protection, sleeping with someone who they knew was not good for them). This subscale possibly has utility in screening for college students whose experience with trauma may lead them to be high risks for exploitation and poor adjustment on a university campus.
The Management of Hepatocellular Carcinoma at the Kara Teaching Hospital (Togo)
Authors: Tamegnon OSSOUVI , Yakoubou EL-HADJI , Komlan Rafiou, ADABRA , Oumboma BOUGLOUGA , Kokou KANASSOUA , Irokoura KASSEGNE , David DOSSEH Ekoué
Published: January 2023

Objective: To describe the epidemiological, diagnostic, therapeutic and evolutionary aspects of hepatocellular carcinoma at CHU Kara. Method: This is a retrospective study conducted over a period of 3 years in the Department of General Surgery and Hepato-Gastroenterology of CHU-Kara (Togo). Were included in our study all patients, aged over 15 years old hospitalized for hepatocellular carcinoma. Results: We recorded 98 cases out of 7237 hospitalized patients, i.e. a frequency of 1.4%. The patients were consisted of 65 men and 33 women with a sex ratio (F/M) of 0.5. The average age was 49 years old. Clinically, painful hepatomegaly was found in all cases; abdominal pain in all cases, poor general condition in 86 patients; collateral venous circulation in 3 cases. Alpha-fetoprotein (AFP) was above 400 ng/ml in all patients. Abdominal imaging revealed diffuse liver involvement in 85 patients (86.7%), a localized nodular appearance in 13 cases (13.3%).All these patients had received symptomatic treatment combining analgesics and antispasmodics. The mortality rate was 97.9% within 12 months. Conclusion: Hepatocellular carcinoma remains a serious condition and its diagnosis is often difficult. It poses a real problem of care in our developing countries.
Mastering the game of hide and seek
Authors:   , Cornel Annelisa Marjan
Published: January 2023

The research described in this thesis focuses on strategies to enhance NBL immunogenicity to improve outcome of children suffering from HR-NBL. The main
objective was to find pharmacological and cell-based strategies to induce one of the most important prerequisites for cytotoxic T-cell engagement: cell surface display of MHC-I. The ultimate goal is to effectively engage T-cells, thereby enhancing anti-tumor cytotoxicity and creating immunological memory to prevent future relapse.

To improve the current therapy regimen, we need to understand why the current strategy fails. The pilot data of the functional, longitudinal immune monitoring strategy we developed shows clues for therapy improvement and emphasizes the potential of such a monitoring strategy to study therapy responses in patients. However, we can show the potential, but we do need collaborative approaches within the European association involved with neuroblastoma research (SIOPEN) to gain enough power to be able to draw firm conclusions in such a rare disease treated with many different treatmentarms.

We identified HDAC inhibition as a promising approach to induce surface display of MHC-I expression on NBL cells, thereby causing in vitro susceptibility to NBL-specific T-cell cytotoxicity. The HDACi Entinostat induces a general increase in factors important in both innate and adaptive immunogenicity, which, to our surprise, was accompanied by a switch towards a more undifferentiated, MES NBL cell lineage. This implies that chemo-resistant NBL cells are more sensitive to immunotherapy, and vice versa. These new insights in cell lineage plasticity in response to chemo- and immunotherapy stresses the importance of considering therapy timing to reach maximum therapy efficacy.

Immune monitoring during therapy revealed that, besides the low immunogenicity of NBL cells in general, immune cells themselves may be dysfunctional, which further complicates the generation of NBL-specific immune responses. Adoptive cell therapy strategies may therefore be required complementary to immunogenicity-enhancing strategies to maximize anti-tumor responses. This thesis hints to the potential of cell therapy strategies which combine natural NK-cell cytotoxicity with TCR-mediated cytotoxicity of T-cells in one cell to overcome MHC-I plasticity-related immune evasion.

Altogether, understanding of the impact of (timing of) individual components of the HR-NBL treatment regimen on tumor destruction, tumor phenotype, immunogenicity, and immune cell function is key to further improve efficacy of the treatment regimen. This thesis identifies and shows the potential of strategies to increase NBL immunogenicity to, among others, T-cells, to induce an NBL-specific immune response and generate immunological memory to prevent future relapse. This is a start, but translating our findings to a fully immunocompetent setting, together with investigation of other immunogenicity-restricting processes, is needed to bring mastering of this game of hide and seek to the next level.
The Green Radiology Department
Authors: Wolf Theo
Published: January 2023

GLOBALLY, hospital-based care has a substantial ecological footprint. In the USA, the health sector generates approximately 10% of the nation’s greenhouse gas emissions. Radiology departments are known to be major energy consumers, particularly through the use of CT scanners, MRI systems, reading workstations, and interventional suites. At this year’s European Congress of Radiology (ECR) 2022 Overture, 2nd–6th March, a panel of experts explored ways to make the discipline more environmentally sustainable.
Residual Cardiovascular Risk in Diabetic Patients: The Role of Fibrate Statin Combination
Authors: Liontos Angelos , Elisaf Moses S. , Filippatos Theodosios D.
Published: January 2023

Patients with Type 2 diabetes mellitus (T2DM) have increased cardiovascular disease (CVD) risk. The use of statins significantly reduces the rate of CVD events but many T2DM patients, especially those with mixed dyslipidaemia (MD), have residual CVD risk. The use of fibrates, which improve triglyceride and high-density lipoprotein cholesterol levels, is beneficial for the treatment of patients with MD. Evidence from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Lipid study showed a possible beneficial effect on CVD events of the addition of fenofibrate (FF) to statin treatment in patients with T2DM and atherogenic MD. Furthermore, FF has been associated with slowing of the progression of early diabetic retinopathy. The combination of statin with a fibrate may improve the residual CVD risk and microvascular complications of patients with T2DM. However, trials specifically designed to assess the effects of fibrate-statin combination on cardiovascular outcomes in patients with T2DM are missing.
The Multiple Facets of Thrombotic Microangiopathies
Authors: Amirthalingam Saroshi
Published: January 2023

The Alexion satellite symposium was introduced by Prof Pier Mannuccio Mannucci who provided an introduction to the history of thrombotic microangiopathies (TMAs). Prof Paul Coppo gave an overview of TMAs and the differential diagnosis of atypical hemolytic-uraemic syndrome (aHUS) and thrombotic thrombocytopaenic purpura (TTP). He emphasised the importance of a suitable differential diagnosis in order to initiate an appropriate treatment as soon as possible, eventually allowing better patient outcomes. Prof Javier de la Rubia discussed the role of the complement pathway and how genetic abnormalities can lead to dysregulation in aHUS. Prof Thorsten Feldkamp concluded by giving an overview of the latest clinical trial data on the efficacy and safety of eculizumab in the management of aHUS.
Next Steps in Front-Line Treatment of Lymphoma: The Road Ahead
Authors: Bell Juliet
Published: January 2023

Prof Zelenetz opened the symposium on the evolving front-line treatment options for follicular lymphoma (FL) and discussed the potential of novel agents to replace chemotherapy. Prof Zelenetz presented the heterogeneity of diffuse large B cell non-Hodgkin’s lymphoma (DLBCL) with regard to the diagnosis and subtypes of DLBCL to describe the specificity of new agents towards certain DLBCL subgroups, whilst Prof Dreyling spoke about the current diagnosis and treatment pathways for mantle cell lymphoma (MCL), and briefly described recent trial results. The final presenter, Prof Coiffier, discussed the lack of efficacy of front-line chemotherapy regimens for peripheral T cell lymphoma (PTCL), and highlighted potential new treatments based upon CHOP (cyclophosphamide, hydroxydaunorubicin, vincristine, prednisone). He then addressed the use of transplantation for first-line and refractory disease, and called for research to optimise therapy using existing agents.
Liver Transplantation For Alcoholic Liver Disease – Time for a Paradigm Shift?
Authors: Staufer Katharina , Berlakovich Gabriela
Published: January 2023

Liver transplantation for alcoholic liver disease (ALD) is controversially discussed. Although overall survival after liver transplantation is similar to other indications, long-term survival is significantly reduced in patients with recurrence of excessive alcohol consumption. Criteria of transplant eligibility and prediction of risk of alcohol relapse after transplantation are the core concerns in this setting. Most transplant centres therefore require an abstention period of 6 months prior to listing. However, data on the ‘6-month rule’ as a surrogate parameter for prediction of relapse are conflicting, and first reports on liver transplantation in highly selected patients with acute alcoholic hepatitis without response to medical treatment are promising. Therefore, a thorough pre-transplant evaluation by an experienced addiction specialist in addition to regular counselling and a highly supportive social surrounding after transplantation seem to be the key factors for long-term survival in ALD patients.
Transforming HCV Management
Authors: Mughal Tabasum
Published: January 2023

This Gilead-sponsored satellite symposium addressed the new and exciting advent of novel therapy in the field of hepatitis C by highlighting recent important clinical trials. The scientific programme covered the history of treatment of hepatitis C and the current and future treatment landscape in the management of hepatitis C virus (HCV) infection.
News at Six: Hepatitis C Special
Authors: Powell Jill
Published: January 2023

This Bristol Myers Squibb-sponsored symposium was chaired by Mark Thursz, who oversaw a novel news bulletin-themed symposium with sessions provided by a distinguished, international team of roving reporters; Charles Gore from the World Hepatitis Alliance, Jean-Michel Pawlotsky from France, Alessandra Mangia from Italy, Ashley Brown and Graham Foster from London, Heiner Wedemeyer from Germany, and Rafael Esteban from Spain.
Расчет несущей способности фундамента на закарстованной территории
Authors: ЕГЕРЕВА Эльвира Николаевна , КИРПИЧНИКОВА Варвара Алексеевна
Published: January 2023

Рассмотрена особенность расчета несущей способности плитного монолитного фундамента здания канализационных очистных сооружений, расположенных в г. Севастополе в условиях строительства на закарстованной территории. Данная тема заслуживает особого внимания, поскольку карстовые районы широко распространены на территории России и относятся к особым условиям строительства. Для предотвращения обрушения здания канализационных очистных сооружений в случае образования карстовой воронки и сейсмических воздействий необходимо учитывать взаимодействие строительной конструкции и ее основания. С этой целью выполняли численный расчет и моделировали возможность образования карстовой воронки в наиболее неблагоприятных местах. В качестве компенсирующих конструктивных мероприятий предложено устройство монолитных плитных фундаментов. По результатам численного расчета несущей конструкции на аварийную ситуацию, проведенного в программном комплексе LIRA Soft, выявлено, что обрушение здания не произойдет в результате перераспределения возникающих усилий. Монолитные железобетонные конструкции фундамента способны воспринять все действующие на них нагрузки и обеспечить безопасную эксплуатацию рассматриваемого сооружения. В статье показано, что перемещений, больших по значению, чем исходные, при нормальной работе объекта у несущих конструкций не происходит в результате перераспределения усилий. Также установлено, что максимальное давление под фундаментной плитой не превышает расчетного сопротивления грунта. Таким образом, плитный монолитный железобетонный фундамент способен компенсировать неблагоприятное воздействие при возможном образовании карстово-суффозионных провалов.
Модель сопротивления сложнонапряженного железобетона при изгибе с кручением
Authors: КОЛЧУНОВ Владимир Иванович , ПРОТЧЕНКО Максим Владимирович , ШАНЬКОВ Вячеслав Николаевич , ГРЕЧИШНИКОВ Сергей Владимирович
Published: January 2023

Построена расчетная модель сопротивления железобетонного элемента при изгибе с кручением. Модель содержит первый и второй блоки отсеченных (поперечных и спиралеобразных) трещин. Из статических и деформационных соотношений составлены разрешающие уравнения для определения расчетных параметров в сечениях этих блоков. В растянутой зоне железобетонной конструкции учитывается "нагельный" эффект в продольной и поперечной арматуре пространственного сечения, определяемый с привлечением специальной модели второго уровня. Учитывается также деформационный эффект в трещинах, физическая суть которого заключается в дополнительном деформационном воздействии при нарушении сплошности бетона. Раскрытие трещин рассчитывается как накопление относительных условных сосредоточенных взаимных смещений арматуры и бетона на смежных участках по обе стороны берегов трещины. При этом в зависимости от расстояния от поверхности контакта с арматурой учитывается депланация бетона в сечении с трещиной. С учетом деформационных эффектов получены аналитические зависимости для определения параметров жесткости и раскрытия пространственных трещин в сложнонапряженных железобетонных конструкциях при изгибе с кручением. Расчетными зависимостями учитывается наличие в конструкции смежных пространственных трещин на разных уровнях нагружения.
Анализ сроков выполнения работ при сооружении атомных электростанций
Authors: ПАВЛОВ Александр Сергеевич , ОСТРОВСКИЙ Роман Вадимович
Published: January 2023

В связи с большим количеством энергоблоков, сооружаемых у нас в стране и за рубежом, актуальными становятся вопросы управления сроками и рисками возведения атомных станций, а также планирования строительного производства. В рамках данного исследования для анализа увеличения плановых продолжительностей выполнения работ из жизненного цикла энергоблока выделены три периода: подготовительный, от "первого бетона" до старта тепломонтажных работ и затем до физического пуска станции. Из проведенного анализа следует, что с увеличением количества работ на последующих этапах сооружения растет как количество работ с увеличенной плановой длительностью, так и среднее отношение увеличенной длительности к плановой с эффектом "нарастания". Однако при наличии временного и ресурсного резерва перед стартом определенных работ можно добиться максимальной вероятности сохранения плановой продолжительности работ и завершения их в утвержденные изначально сроки. В процессе сооружения атомной электростанции по различным причинам увеличивается плановая продолжительность производства работ. Избежать нежелательных последствий и при этом повысить эффективность управления проектом в части сроков позволит планирование временного и ресурсного запаса для определенных видов работ, а также выбор верных методов оптимизации продолжительности строительства.
BIMBINGAN TEKNIS PENINGKATAN PRODUKTIVITAS USAHA DAN PENDAPATAN PETANI MELALUI PENERAPAN MANAJEMEN AGRIBISNIS DI DESA ALEBO, KECAMATAN KONDA KABUPATEN KONAWE SELATAN
Authors: Gafaruddin Abdul , Alwi La Ode , Ido Irfan
Published: January 2023

The ability of agricultural business human resources in rural areas in business management is still lacking because most of them have low education, only based on experience and training or counseling from related agencies. Most of the business capital comes from their own capital and partly is a capital strengthening fund from the government for the community through the Department of Agriculture. Production management is still simple and the marketing of agricultural business products is mainly marketed in the form of logs and is still on a local scale. Therefore, efforts to develop community businesses in rural areas are needed, one of which is through business management technical guidance. Business Management technical assistance is part of Partnership Technical Guidance Activities. To Improve the Quality of Human Resources in Southeast Sulawesi which was carried out by the Southeast Sulawesi Provincial Agriculture Service on 19 - 20 September 2022 which was attended by 20 participants. The results of the technical assistance showed that the majority (70%) of the training participants knew and were able to explain the importance of recording business transactions, while 10 people (50%) were able to record business transactions and 5 people (25%) had continued with the preparation of financial reports. (income statement and balance sheet). In addition, participants have also tried to utilize the information from the financial statements to make future business projections.
Evaluating Whether a Learning by Doing Initiative Meets DEI Goals
Authors: Sokhey Sarah
Published: January 2023

How can we best evaluate if a learning by doing initiative is accomplishing its goals including its priorities in advancing diversity, equity, and inclusion? Drawing on my own previously co-authored published work (Nonnemacher and Sokhey 2022), I discuss how diversity and inclusion goals inspired the creation of an undergraduate research lab at a large flagship state university. Studio Lab was created to match research mentors with undergraduate students who work as paid research assistants at the University of Colorado Boulder. In 2020 Studio Lab began in the Department of Political Science, in 2021 it expanded to the Division of Social Sciences, and in 2022 it expanded to the College of Arts & Sciences. I present suggestions for those wishing to advance similar initiatives. I then focus on the DEI goals associated with the lab and provide a template for evaluating whether these goals are being met.
Role-Playing Across Universities: NATOs Response to the Invasion of Ukraine
Authors: Callaway Rhonda , Harrelson-Stephens Julie
Published: January 2023

The global pandemic fundamentally reshaped how students and faculty think about education. The immediate need for meaningful instruction and learning experiences spurred innovation in online and hybrid course delivery. Even as students return to the classroom, faculty must anticipate future needs for online instruction. Students enrolled in an courses in the Fall 2022 semester at SHSU and SFASU participated in a joint, virtual simulation as a class exercise. This cross-university experience allowed students to gain perceptions and relationships outside their own university with students pursuing similar academic interests and goals. The goals of the simulation were two-fold: (1) enhance international national relations content knowledge regarding a regional intergovernmental organization and alliance behavior, and (2) develop 21st century skills such as collaboration, communication, and decision-making. This paper focuses on our rationale for the simulation, our experience as faculty members, and our plans to improve the simulation for the Fall 2023 semester.
Development and validation of a live birth prediction model for expected poor ovarian response patients during IVF/ICSI
Authors: Gong Xiaoyun , Zhang Yunian , Zhu Yuejie , Wang Peng , Wang Zhihui , Liu Chen , Zhang Manli , La Xiaolin
Published: January 2023

Background

A number of live birth predictive model during assisted reproductive technology treatment have been available in recent years, but few targeted evaluating the chances of live birth in poor ovarian response(POR) patients. The aim of this study was to develop a nomogram based on POSEIDON criteria to predict live birth in patients with expected POR.

Methods

This retrospective cohort study using clinical data from 657 patients in POSEIDON Groups 3 and 4 (antral follicle count [AFC] ≤5 and AMH <1.2 ng/ml) in the Center for Reproductive Medicine, First Affiliated Hospital of Xinjiang Medical University, and Construction a nomogram model t

Results

Among 657 expected POR patients, 111 (16.89%) had live births, and 546 (83.11%) did not have live births. These were divided into a training set(n=438) and a validation set (n=219). Multivariate logistic regression analysis showed that the age (OR = 0.91, 95% CI: 0.86–0.97), BMI (OR = 1.98, 95% CI: 1.09–3.67), AMH (OR = 3.48, 95% CI: 1.45–8.51), normal fertilized oocytes (OR = 1.40, 95% CI: 1.21–1.63), and the basal FSH (OR = 0.89, 95% CI: 0.80–0.98) of the female were independent factors predicting live birth in patients with expected POR. Then, an individualized nomogram prediction model was built from these five factors. The area under the ROC curve of the live birth prediction model was 0.820 in the training set and 0.879 in the validation set.

Conclusion

We have developed a nomogram combining clinical and laboratory factors to predict the probability of live birth in patients with an expected POR during IVF/ICSI, which can helpful for clinician in decision-making. However, the data comes from the same center, needs a prospective multicenter study for further in-depth evaluation and validation of this prediction model.