bluuebunny/crossref_metadata_2025 huggingface dataset:
Tumor mutation burden and depression in lung cancer: Association with inflammation.
Authors: McFarland Daniel Curtis , Jutagir Devika R , Rosenfeld Barry , Miller Andrew H. , Nelson Christian J. , Breitbart William
Published: March 2020

e23159

Background: Depression and inflammation are both associated with lung cancer. Tumor Mutation Burden (TMB) can be used to predict immunotherapy response which relies on tumor immunogenicity, a form of inflammation. This study evaluated whether higher TMB was associated with increased depression and various forms of inflammation. Methods: Patients with metastatic Non-small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC) receiving anticancer treatments were evaluated for depression severity using the Hospital Anxiety and Depression Scale (HADS). TMB was measured using Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT). Inflammation was evaluated using C - reactive protein (CRP) and the Neutrophil to Lymphocyte Ratio (NLR). Results: Ninety-six out of 140 participants with adequate TMB testing were evaluated (68.6%). The average number of mutations was 10.8 (SD 10.8). Twenty-four percent met screening criteria for depression. TMB correlated with depression severity (r = .34, p = .001) and NLR (r = .37, p = .002) and absolute neutrophil count (r = .3, p = .006) but not CRP (r = .193, p = .06). TMB was higher in patients receiving chemotherapy (12.0) and immunotherapy (14.4) over targeted therapy (4.8). A multivariate model found that TMB (β = .25, p = .032) and CRP (β = .36, p = .003) predicted for depression severity. Conclusions: TMB is an independent predictor of depression. Inflammatory indices suggest a possible relationship but the exact mechanism should be further evaluated and the results warrant replication. Ultimately, these findings may help identify lung cancer patients at risk for depression. [Table: see text]
Inherited Missense Mutation Occurring in Arginine76 of theSRYGene Does Not Account for Familial 46, XY Sex Reversal
Authors: Wang Nan , Zhu Wenjiao , Han Bing , Wang Hao , Zhu Hui , Chen Yingchao , Chen Yan , Liu Jianhua , Liu Yang , Zhao Shuangxia , Song Huaidong , Qiao Jie
Published: March 2020

Background

SRY (sex determining region of Y) is one of the important genes involved in the process of human sex determination. The disturbed sex determination caused by an SRY mutation accounts for 10% to 15% of cases with 46, XY sex reversal. Recently, 3 distal enhancers were identified upstream of the SOX9 gene.

Objectives

The purpose of this study was to investigate the molecular etiology of 46, XY sex reversal in 3 familial patients and a sporadic patient.

Design

Next-generation sequencing was used to reveal the genotype and inherited pattern. Copy number variations and single nucleotide polymorphism haplotyping were analyzed to observe the alteration of enhancers of SOX9. Transcriptional activity of SRY mutation were assessed by a dual luciferase reporting system, and nuclear translocation was observed by confocal microscopy.

Results

Two novel SRY gene mutations, p.Arg76Leu and p.Glu89flx15, were identified. In the pedigree with multiple patients, p.Arg76Leu mutation in SRY and p.Gly212Ser mutation in NR5A1 were identified in the proband. The heterozygous deletion far upstream of the SOX9 gene in chromosome 17 was identified in the 3 patients in this family, containing the distal enhancer eSR-A of SOX9 but not eSR-B and eALDI. The frameshift mutation p.Glu89flx15 was revealed to inhibit the transcriptional activity of the target gene, whereas the missense mutation p.Arg76Leu barely showed an effect.

Conclusion

In contrast to sporadic cases, inherited single nucleotide variations of SRY are not the main cause of the severe phenotype of 46, XY sex reversal, and the enhancers of SOX9 should be investigated carefully in such patients.
p53, cancer and the immune response
Authors: Blagih Julianna , Buck Michael D. , Vousden Karen H.
Published: March 2020

The importance of cancer-cell-autonomous functions of the tumour suppressor p53 (encoded by TP53) has been established in many studies, but it is now clear that the p53 status of the cancer cell also has a profound impact on the immune response. Loss or mutation of p53 in cancers can affect the recruitment and activity of myeloid and T cells, allowing immune evasion and promoting cancer progression. p53 can also function in immune cells, resulting in various outcomes that can impede or support tumour development. Understanding the role of p53 in tumour and immune cells will help in the development of therapeutic approaches that can harness the differential p53 status of cancers compared with most normal tissue.
Transarterial embolization of acute iatrogenic hemorrhages: predictive factors for mortality and outcome
Authors: Pech Maciej , Serafin Zbigniew , Fischbach Frank , Damm Robert , Jargiełło Tomasz , Seidensticker Max , Powerski Maciej
Published: March 2020

Objective:

Iatrogenic hemorrhages occur in 0.5–16% of medical procedures. A retrospective study was conducted to analyze technical and clinical outcome of transarterial embolization (TAE) used for acute iatrogenic hemorrhage and to identify factors predicting outcome.

Methods:

All patients undergoing TAE for acute iatrogenic bleeding from 2006 to 2013 were retrospectively analyzed. Primary end points were technical and clinical success or failure and 30 day mortality.

Results:

A total of 153 patients underwent 182 TAEs. Factors associated with clinical failure were lower blood hemoglobin concentration, use of higher number of units of red blood cell concentrate, TAE performed at night or weekend, embolization of more than one vessel, shock state before digital subtraction angiography (DSA), and intensive care before TAE. In multivariate analysis, independent factors for clinical success were hemoglobin concentration, number of units of red blood cell concentrate, and TAE of more than one vessel. Technical failure was associated with female gender, failure to detect signs of bleeding in DSA, TAE of more than one vessel, and shock state before DSA. Bleeding related to anticoagulation medication resulted in a significantly higher mortality rate compared with bleeding due to the remaining causes (30% vs 15%, p < 0.05).

Conclusion:

Despite excellent technical success, the mortality rate was significant. The only factors affecting clinical success were bleeding intensity and extent of injury. Bleeding attributed to anticoagulation is related to high mortality and therefore requires special attention.

Advances in knowledge:

This study gives insights into morbidity and mortality of iatrogenic bleedings and the technical and clinical success rates of TAE in a large study population.
Ultrasound elastography in characterization of prostatic lesions: correlation with histopathological findings
Authors: Emara Doaa M , Naguib Nagy N. , Yehia Mohamed , El Shafei Mohamed M.
Published: March 2020

Objective:

Ultrasound elastography is increasingly used in the diagnosis of prostate cancer, however results are heterogeneous. We correlate in a large sample-size prospective study the accuracy of elastography, aiming to settle an accurate cut-off point for diagnosis and possibility of use as a screening tool.

Methods:

Prospective study that included 120 patients with mean age 59.5 ± 9.8 years, showing enlarged prostate by clinical examination with prostate-specific antigen >4 ng ml−1.

The study was done using high frequency high resolution endorectal probe with real time tissue elastography.

Grayscale ultrasound examination was done first with Doppler followed by elastography color-coded map and strain ratio measurement. Then, transrectal ultrasound-guided core biopsy was done from suspicious areas detected by elastography (totally or partly stiff by color-coded map or with relative increased strain ratio), besides standard six-quadrant core biopsy samples.

Results:

There was statistically significant difference (p < 0.001) regarding strain ratio in benign and malignant lesions. Strain ratio showed significant proportionate correlation with prostate-specific antigen level and Gleason pathological score, while no significant correlation noted with the age or the prostatic volume. A strain ratio with a cut-off value of 1.9 showed a sensitivity of 100%, specificity 93.8%, positive predictive value of 79.3%, negative predictive value 100 and 95% accuracy in differentiating between malignant and benign lesions.

Conclusion:

Strain ratio improves the detection of prostatic cancer with high sensitivity (100%) and high negative predictive value (100%).

Advances in knowledge:

Different prostatic lesions are mostly similar in grayscale ultrasound.

Imaging plays an important role in differentiation of prostatic nodules.

Ultrasound elastography may play an important role in distinguishing benign from malignant nodules.
Del reconeixement a la comunicació científica. La presència de la dona als Premis Nacionals d''Investigació (1982–2019).
Authors: Segarra Saavedra Jesús , Hidalgo Marí Tatiana , Tur Viñes Victoria
Published: March 2020

Objective. This study analyses the history of the "Premios Nacionales de Investigación", a suite of awards for scientific research organised by the Spanish government, from the creation of the first awards in 1982 to 2019 and from the perspective of gender, in order to identify differences and similarities between the awards given to men and to women.

Methodology. The study describes and compares the awards using the five indicators award name, area of research, recipient, recipient gender and award money. To determine the scope, visibility and impact of the awards, the study also examines the award winners' presence in Google Scholar using the four indicators presence, citations, h-index and i10-index.

Results. The overall results reveal a persistent and pronounced gender gap. Of the 113 awards granted in the period under study, 102 (92.3%) went to men, and of the 1,340,649 citations counted in Google Scholar, only 4.7% were of women authors. The study concludes that women are clearly under-represented in Spain's national awards for scientific research, although when the data are related to visibility in Google Scholar, the results regarding the dissemination of research by women is more promising.
Differential interference contrast microscopy with adjustable plastic Sanderson prisms
Authors: Rathi Sonika , Zoubek Nicholas , Zagarese Vivian J. , Johnson Daniel S.
Published: March 2020

Differential interference contrast (DIC) microscopy is a technique to image spatially dependent gradients in optical path lengths. Contrast is produced through the splitting of polarized light with quartz Wollaston prisms. Here we demonstrate that light splitting for DIC microscopy can also be achieved with Sanderson prisms consisting of polycarbonate bars under a bending load. Comparable image contrast while imaging cultured cells was achieved with this alternative technique. These results demonstrate an inexpensive and easily adjustable alternative to traditional quartz Wollaston prisms.
Simultaneous detection of SRI and temperature with a SLPFG sensor operating near PMTP
Authors: Ling Qiang , Gu Zhengtian , Pang Bo
Published: March 2020

In our paper, a superimposed long-period fiber grating (SLPFG) sensor based on the dual-peak resonance near the phase-matching turning point (PMTP) for simultaneously detecting surrounding refractive index (SRI) and temperature is proposed. For the SLPFG, two fiber gratings with different periods are overlapped and written in the same fiber core. There are two resonant peaks in the transmission spectrum corresponding to the above gratings and different cladding modes. By adjusting the grating periods, one resonant peak corresponds to a little off-resonant state near the PMTP, while the other one corresponds to the single peak state. When the SRI and temperature change, the transmissivity of the resonant peak in the little off-resonant state changes accordingly at fixed wavelength, and the resonant peak in the single peak state shifts. Results of numerical simulations demonstrate that SRI and temperature simultaneous measurement can be achieved by monitoring the wavelength shift of the left peak and the transmissivity of right peak. For the left peak, the SRI and temperature sensitivities are

−

628.57

n
m

/

R
I
U

and

−

0.20

n
m

/

∘

C

, respectively. For the right peak, the SRI sensitivity is from

−

217.73

d
B

/

R
I
U

to

−

682.47

d
B

/

R
I
U

when the SRI varies from 1.330 to 1.360. The temperature sensitivity is from

−

0.044

d
B

/

∘

C

to

−

0.101

d
B

/

∘

C

when the temperature varies from 20°C to 120°C. The SRI and temperature sensitivities of such sensors are 7 times and 20 times higher than those of other sensors with dual-parameter modulation of intensity and wavelength. The proposed sensor with high sensitivity and simplified structure can be extended to multi-parameter measurement.
A Hybrid-Integrated 400G TROSA Module Using Chip-to-Chip Optical Butt-Coupling
Authors: Han Young-Tak , Yun Seok-Jun , Jung Hyun-Do , Kim Seok-Tae , Shin Jang-Uk , Park Sang-Ho , Lee Seo-Young , Baek Yongsoon
Published: March 2020

Using an optical butt-coupling method, we have developed a low-cost hybrid-integrated 4×100G TROSA module, showing clear Tx optical eye patterns and Rx sensitivities within −7.0 ~ −6.4 dBm at 106-0bps PAM4 signals for all channels.
Generation and Coherent Detection of 2-µm-band WDM-QPSK Signals by On-chip Spectral Translation
Authors: Kong Deming , Liu Yong , Ren Zhengqi , Jung Yongmin , Pu Minhao , Yvind Kresten , Galili Michael , Oxenløwe Leif K , Richardson David J , Hu Hao
Published: March 2020

We have proposed and demonstrated the generation and coherent detection of 2-µm-band I/Q modulated signals for the first time using on-chip spectral translation. 6×32 Gbaud WDM-QPSK signals exhibit BERs below the 7% HD-FEC threshold.
Non-Orthogonal Matrix Precoding based Faster-than-Nyquist Signaling over Optical Wireless Communications
Authors: Hu Zhouyi , Chan Chun-Kit
Published: March 2020

We first investigate a novel non-orthogonal matrix precoding based faster-than-Nyquist signaling technology in OWC systems. Compared to the conventional schemes, it shows superior performance including PAPR reduction, improved sensitivity, and improved tolerance to narrow-bandwidth filtering.
Broadband 145GHz Photodetector Module Targeting 200GBaud Applications
Authors: Runge Patrick , Ganzer Felix , Gläsel Jonas , Wünsch Sebastian , Mutschall Sven , Schell Martin
Published: March 2020

We demonstrate a photodetector module with a 0.8mm-RF connector and an estimated 3dB-bandwidth of 145GHz. The bandwidth of the module exceeds all other state of the art photodetector modules. The intended application of the module is for test and measurement equipment of next generation optical networks with 200GBaud.
120 Gb s-1 Hybrid Silicon and Lithium Niobate Modulators with On-Chip Termination Resistor
Authors: Sun Shihao , He Mingbo , Xu Mengyue , Zhang Xian , Ruan Ziliang , Liu Liu , Cai Xinlun
Published: March 2020

We demonstrated hybrid silicon and lithium niobate Mach-Zehnder modulators with on-chip termination resistor. The device shows high electro-optic bandwidth up to 60 GHz, low Vπ of 2.25 V and low insertion loss of 2 dB.
Digital holographic endo-microscopes based on multimode fibres
Authors: Čižmár Tomáš
Published: March 2020

Here I review the recent progress of endo-microscopes based on holographic control of light transport through multimode fibres. I discuss the fundamental and technological bases as well as recent applications of the new imaging tool.
Characterization of Multi-Core Fiber Group Delay with Correlation OTDR and Modulation Phase Shift Methods
Authors: Azendorf Florian , Dochhan Annika , Wilczyński Krzysztof , Szostkiewicz Łukasz , Urban Patryk , Schmauss Bernhard , Vilchez Francisco Javier , Nadal Laia , Moreolo Michela Svaluto , Fabrega Josep M. , Eiselt Michael
Published: March 2020

Using a Correlation-OTDR and a modulation phase shift method we characterized four multi-core fibers. The results show that the differential delay depends on the position of the core in the fiber and varies with temperature.
Investigation of Brillouin Dynamic Grating in 4-LP-mode Fiber with a Ring-cavity Configuration for Distributed Temperature and Strain Sensing Application
Authors: Liu Yinping , Yang Guangyao , Wang Ning , Ma Lin , Alvarado-Zacarias J. C. , Antonio-Lopez J. E. , Sillard Pierre , Amezcua-Correa A. , Amezcua-Correa R. , Fan Xinyu , He Zuyuan , Li Guifang
Published: March 2020

We investigate temperature and strain dependency of Brillouin dynamic grating in 4-LP-mode fiber with a ring-cavity configuration. Sensitivities of 3.20 MHz/°C and −0.0384 MHz/με are achieved. We demonstrate measurement with 300-m range and 1-m resolution.
Probabilistic-Shaping DP-16QAM CFP-DCO Transceiver for 200G Upgrade of Legacy Metro/Regional WDM Infrastructure
Authors: Loussouarn Y. , Pincemin E.
Published: March 2020

We investigate here the capability of a newly developed CFP-DCO interface, operating at both 34 Gbaud with uniform DP-16QAM and 39 Gbaud with probabilistic-shaping DP-16QAM, for 200G upgrade of legacy metro/regional WDM infrastructure already working at 10G or 100G.
Joint Optimization of Processing Complexity and Rate Allocation through Entropy Tunability for 64-/256-QAM Based Radio Fronthauling with LDPC and PAS-OFDM
Authors: Zhang Rui , Chen You-Wei , Shen Shuyi , Zhou Qi , Yao Shuang , Su S.-J. , Alfadhli Yahya , Chang Gee-Kung
Published: March 2020

We experimentally demonstrate LDPC coded PAS-OFDM 64-/256-QAM signals in radio fronthauls. Through entropy allocation by adjusting the complexity and signal bandwidth, tunable power margins gain up to 3 dB and relaxed process latency are achieved.
Wide FoV Autonomous Beamformer Supporting Multiple Beams and Multi-Band Operation for 5G Mobile Fronthaul
Authors: Huang Min-Yu , Chen You-Wei , Shiu Run-Kai , Wang Hua , Chang Gee-Kung
Published: March 2020

An autonomous beamformer covering 24-37 GHz for fiber-wireless network demonstrates multi-beam and multi-band signal transmission with wide-FoV (110o-180o) self-steering beam-tracking/-forming over a 10-km fiber and 56-cm wireless link for future dynamic 5G-NR fronthaul applications.
Spatial Channel Network (SCN): Introducing Spatial Bypass Toward the SDM Era
Authors: Jinno Masahiko , Kodama Takahiro
Published: March 2020

We review the spatial-channel network technology toward the spatial-division-multiplexing era from the viewpoints of network and node architectures, physical performance, network-resource utilization efficiency, and novel optical switches for modular and low-loss spatial cross-connects.
Real-time Assessment of PtP/PtMP Fixed Access Serving RAN with MEC Capabilities
Authors: Ankouri Anas El , Rincón Santiago Ruano , Simon Gaël , Neto Luiz Anet , Amigo Isabel , Gravey Annie , Chanclou Philippe
Published: March 2020

In this paper we propose the introduction of an intelligent access network equipment capable of hosting Mobile Edge Computing capabilities in a convergence scenario of PtP and PtMP topologies.
Analysis and Demonstration of Ultra-Broadband Mach-Zehnder Hybrid Polymer/Sol-Gel Waveguide Modulators
Authors: Enami Yasufumi , Seki Atsushi , Masuda Shin , Luo Jingdong , Jen Alex K-Y.
Published: March 2020

A bandwidth of the hybrid modulators is calculated numerically and analytically based on experimentally obtained device parameters, which is >130 GHz. The electro-optic response is reduced by < 2 dB at 67 GHz. The electrical transmission S21 is reduced by 5 dB at 110 GHz (upper limit) of a vector network analyzer, which also assured the bandwidth.
Optical Interconnects Using Single-Mode and Multi-Mode VCSEL and Multi-Mode Fiber
Authors: Ledentsov N. N. , Shchukin V.A. , Kalosha V.P. , Ledentsov N. , Chorchos L. , Turkiewicz J. P. , Hecht U. , Kurth P. , Gerfers F. , Lavrencik J. , Varughese S. , Ralph S. E.
Published: March 2020

Single mode (SM) VCSELs, produced in industrial 4” technology, are suitable for 100Gb/s PAM2 and >160Gb/s PAM4 data transmission. >107Gb/s transmission over 1km of multimode (MM) fiber at 850nm and 910nm is realized.
Ultra-low loss and fabrication tolerant silicon nitride (Si3N4) (de-)muxes for 1-μm CWDM optical interconnects
Authors: Cheung Stanley , Tan Michael R. T.
Published: March 2020

Low-loss, fabrication-tolerant Si3N4 CWDM lattice filters and AWGs are demonstrated for 990 – 1065nm bottom-emitting VCSELs. Channel separation of 25 nm, XT < -35 dB and −20 dB are reported with temperature shift of 14.5 pm/°C.
Experimental Demonstration of Widely Tunable Rate/Reach Adaptation From 80 km to 12,000 km Using Probabilistic Constellation Shaping
Authors: Gené Joan M. , Chen Xi , Cho Junho , Chandrasekhar Sethumadhavan , Winzer Peter
Published: March 2020

We experimentally demonstrate the rate/reach adaptability of probabilistically constellation-shaped quadrature amplitude modulation across from 80 km to 12,000 km using the same 32-GBaud transponder hardware and highlight the roles of template and shaping distribution.
Reconfigurable Radiofrequency Photonic Filters Based on Soliton Microcombs
Authors: Hu Jianqi , He Jijun , Raja Arslan S. , Liu Junqiu , Kippenberg Tobias J. , Brès Camille-Sophie
Published: March 2020

We demonstrate soliton based radiofrequency filters using a 104 GHz Si3N4 microresonator. The filter passband frequencies are widely reconfigured via inherent soliton states of perfect soliton crystals and two-soliton microcombs, without any external pulse shaping.
Modulation Classification based on Deep Learning for DMT Subcarriers in VLC System
Authors: Liu Wu , Li Xiang , Yang Chao , Luo Ming
Published: March 2020

We propose a deep learning(DL) enabled modulation classification scheme using only dozens of received symbols. For each DMT subcarrier in VLC system, experiments achieve 100% classification accuracy rate using 75 symbols received at BER threshold.
FTN SSB 16-QAM Signal Transmission and Direct Detection using a THP-MIMO-FFE
Authors: An Shaohua , Li Jingchi , Pang Hongxin , Li Xingfeng , Su Yikai
Published: March 2020

A joint equalization scheme consisting of Tomlinson-Harashima precoding and MIMO-FFE is proposed to effectively mitigate the ISI induced by FTN signaling. We experimentally demonstrate a 28-GBaud 16-QAM signal transmission with a record 16.67% FTN ratio.
An OLS Controller for Hybrid Fixed / Flexi Grid Disaggregated Networks with Open Interfaces
Authors: Casellas Ramon , Vílchez F. Javier , Rodríguez Laura , Vilalta Ricard , Fàbrega Josep M. , Martínez Ricardo , Nadal Laia , Moreolo Michela Svaluto , Muñoz Raul
Published: March 2020

We report the design and implementation of an OLS controller in a hierarchical (partial & full) disaggregation, using open standard data models. We detail the constrained path computation in hybrid fixed/flexi networks and its testbed validation.
Disaggregated, Sliceable and Load-aware Optical Metro Access Network for 5G applications and Service Distribution in Edge Computing
Authors: Pan Bitao , Xue Xuwei , Wang Fu , Magalhães Eduardo , Morro Roberto , Riccardi Emilio , Calabretta Nicola
Published: March 2020

A disaggregated, sliceable metro-access ring with SDN control is demonstrated with the use case of service distribution in the edge computing nodes. Successful SDN controlled dynamic network slicing generation, load-aware bandwidth resources assignment is implemented.
Demonstration of Precise Planning of Broadband Access Network based on Mining Traffic Trends and Demands from Hybrid Data Sources
Authors: Li Hui , Guo Xianyi , Zhan Tianshun , Jia Wu , Su Yudan , Yang Guangsheng , Sun Jinglei , Shao Yan , Ji Yuefeng , Wang Guangquan
Published: March 2020

We demonstrate a carrying capability evaluation system, which can evaluate and predict the access network capacity and efficiency by extracting detail network status and trends from hybrid data sources based on machine learning.
Technology Trends for Mixed QKD/WDM Transmission up to 80 km
Authors: Alléaume Romain , Aymeric Raphaël , Ware Cédric , Jaouën Yves
Published: March 2020

We give a survey of some of the recent progress made in deploying quantum and classical communications over a shared fiber, focusing in particular on results obtained using continuous-variable QKD.
Colorless, Partially Directional, and Contentionless Architecture for High-Degree ROADMs
Authors: Li Yongcheng , Zong Liangjia , Gao Mingyi , Mukherjee Biswanath , Shen Gangxiang
Published: March 2020

We design a new Colorless, partially Directional, and Contentionless (CpDC) architecture for high-degree ROADMs, in which a fixed interconnection pattern is developed to connect different nodal degrees and add/drop modules. Simulation results show the advantages of the proposed architecture to significantly reduce the cost, insertion loss, and volume.
Reliable Slicing with Isolation in Optical Metro-Aggregation Networks
Authors: Marotta A. , Cassioli D. , Tornatore M. , Hirota Y. , Awaji Y. , Mukherjee B.
Published: March 2020

We discuss how different degrees of slice isolation influence resource allocation in protected optical metro-aggregation networks. The case of slice reliability with dedicated protection at lightpath is modelled and numerically evaluated.
Is there a most appropriate channel spacing in WDM networks when individually routing 67 GBaud carriers?
Authors: Zami Thierry , Lavigne Bruno
Published: March 2020

As elastic optical transponders faster than 60 GBaud emerge in meshed terrestrial WDM networks, we investigate whether 75 GHz spectral channel spacing outperforms 87.5 GHz spacing when routing individual optical carriers transparently through optical nodes.
Network Design Framework Exploiting Low-Margin Provisioning of Optical Shared Restoration Resources
Authors: Moniz Daniela , Pedro João , Pires João
Published: March 2020

This paper proposes a network design framework tailored to support optical restoration with low-margins by exploiting real-time performance monitoring. Simulation results highlight that it enables resource savings without additional risks of traffic disruption.
Si PIC Based on Photonic Crystal for LiDAR Applications
Authors: Baba T. , Ito H. , Abe H. , Tamanuki T. , Hinakura Y. , Tetsuya R. , Maeda J. , Kamata M. , Kurahashi R. , Shiratori R.
Published: March 2020

Wide-range nonmechanical beam steering is available by an array of Si photonic crystal slow-light waveguides and their switching without complicated control. FMCW LiDAR action is obtained with this beam steering on a Si photonics chip.
Clock Recovery Limitations in Probabilistically Shaped Transmission
Authors: Barbosa Fabio A. , Rossi Sandro M. , Mello Darli A. A.
Published: March 2020

We assess the performance of the modified Gardner timing error detector under probabilistic shaping. The results indicate severe limitations in specific combinations of shaping and roll-off factors. The results are validated by simulations and experiments.
49.2-Tbit/s WDM Transmission Over 2x93-km Field-Deployed Fiber
Authors: Schuh Karsten , Buchali Fred , Dischler Roman , Chagnon Mathieu , Aref Vahid , Buelow Henning , Hu Qian , Pulka Florian , Frascolla Massimo , Alhammadi Esmaeel , Samhan Adel , Younis Islam , El-Zonkoli Mohamed , Winzer Peter
Published: March 2020

We present 40 channel WDM transmission experiments over one and two spans of 93-km field-deployed SSMF achieving net capacities of 51.5-Tbit/s and 49.2-Tbit/s for PCS-256-QAM with 7.5 bits entropy and 45.9-Tbit/s and 45.1-Tbit/s for 64-QAM transmission, respectively.
Low-loss Low-MDL Core Multiplexer for 3-Core Coupled-core Multi-core Fiber
Authors: van der Heide Sjoerd , Alvarado-Zacarias Juan Carlos , Fontaine Nicolas K. , Ryf Roland , Chen Haoshuo , Amezcua-Correa Rodrigo , Koonen Ton , Okonkwo Chigo
Published: March 2020

A fiber-based core multiplexer is designed, fabricated, and evaluated. Insertion losses vary between 0.74 dB and 0.91 dB. Digital holography reveals mode-dependent loss fluctuates between 0.3 dB and 0.9 dB across C- and L-band.
10-Gbit/s Sky-Blue Distributed Feedback Laser Diode-Based Visible Light Communication
Authors: Kong Meiwei , Holguin-Lerma Jorge A. , Alkhazragi Omar , Sun Xiaobin , Ng Tien Khee , Ooi Boon S.
Published: March 2020

A novel sky-blue (~480 nm) InGaN-based distributed feedback laser diode is developed for high-speed visible light communication. With a 3-dB system bandwidth of ~1.5 GHz, 10 Gbit/s is achieved by using orthogonal frequency-division multiplexing technology.
10 Tbit/s QAM Quantum Noise Stream Cipher Coherent Transmission over 160 km
Authors: Yoshida Masato , Kan Takashi , Kasai Keisuke , Hirooka Toshihiko , Nakazawa Masataka
Published: March 2020

We present the first 10 Tbit/s secure physical layer transmission over 160 km with a spectral efficiency of 6 bit/s/Hz by using digital coherent QAM quantum noise stream cipher (QNSC) and injection-locked WDM techniques.
Experimental Demonstration of High Key Rate and Low Complexity CVQKD System with Local Local Oscillator
Authors: Ren Shengjun , Yang Shuai , Wonfor Adrian , Penty Richard , White Ian
Published: March 2020

We experimentally demonstrate a 250MHz repetition rate Gaussian-modulated coherent-state CVQKD with local local oscillator implementation which is capable of realizing record 14.2 Mbps key generation in the asymptotic regime over 15km of optical fiber.
Digital Self-Coherent Continuous Variable Quantum Key Distribution System
Authors: Eriksson Tobias A. , Luís Ruben S. , Gümüş Kadir , Rademacher Georg , Puttnam Benjamin J. , Furukawa Hideaki , Wada Naoya , Awaji Yoshinari , Alvarado Alex , Sasaki Masahide , Takeoka Masahiro
Published: March 2020

We investigate a continuous variable quantum key distribution system with digital tracking of both polarization and phase. Stable operation over 25km for 36 hours with secret key rates between 1.9 and 2.8 Mbit/s is demonstrated.
Silicon Photonics for 100Gbaud
Authors: Zhou Jianying , Wang Jian , Zhang Qun
Published: March 2020

We reviewed recent breakthroughs on silicon photonic for 100Gbaud operation. We experimentally demonstrated 120Gbaud QPSK and 100Gbaud 32QAM operations using a high performance all-silicon IQ modulator with extinction ratio of >25dB and 6dB-bandwidth of 50GHz.
Computationally Efficient 120 Gb/s/λ PWL Equalized 2D-TCM-PAM8 in Dispersion Unmanaged DML-DD System
Authors: Fu Yan , Kong Deming , Xin Haiyun , Bi Meihua , Jia Shi , Zhang Kuo , Hu Weisheng , Hu Hao
Published: March 2020

We proposed a PWL equalizer in 120 Gb/s 2D-TCM-PAM8 based DML-DD system to correct eye skew. Computationally efficient 120 Gb/s 8-state 2D-TCM-PAM8 over 2 km C-band transmission is demonstrated below HD-FEC (3.8×10−3).
Up to 30-Fold BER Improvement Using a Data-Dependent FFE Switching Technique for 112Gbit/s PAM-4 VCSEL Based Links
Authors: Hecht Urs , Ledentsov Nikolay , Chorchos Łukasz , Kurth Patrick , Ledentsov Nikolay N. , Gerfers Friedel
Published: March 2020

In this paper, a dynamic non-linear data-dependent FFE coefficient switching technique, achieving an up to 30-fold decrease in BER in comparison to the linear FFE, is presented. Using the structure 56Gbaud PAM-4 is demonstrated.
Analysis of Service Blocking Reduction Strategies in Capacity-limited Disaggregated Datacenters
Authors: Pagès Albert , Agraz Fernando , Spadaro Salvatore
Published: March 2020

Disaggregated DCs offer multiple benefits. However, transmission capacity limitations at blade level can severely degrade their performance. We analyze several strategies to enhance their service acceptance.
Real-Time Node Local Control for Ultra-Dynamic and Deterministic All-Optical Intra Data Center Networks
Authors: Szczerban Mijail , Estarán José , Benzaoui Nihel , Mardoyan Haїk , Pointurier Yvan
Published: March 2020

We enable ultra-dynamic features in scheduled optical data centers through a novel control mechanism local to each node. We experimentally show sub-μs resource allocation, at least halving distributed computing application completion time.
Scaling HPC Networks with Co-packaged Optics
Authors: Maniotis P. , Schares L. , Lee B. G. , Taubenblatt M. A. , Kuchta D. M.
Published: March 2020

We propose an HPC network architecture with co-packaged optics enabling 128-port 51.2-Tb/s switches. Simulations for a >34,000-GPU system show up to 11.2x throughput improvement over a Summit-like supercomputer, opening the way to direct-network-attached GPUs.
Hybrid Machine Learning EDFA Model
Authors: Zhu Shengxiang , Gutterman Craig , Montiel Alan Diaz , Yu Jiakai , Ruffini Marco , Zussman Gil , Kilper Daniel
Published: March 2020

A hybrid machine learning (HML) model combining a-priori and a-posteriori knowledge is implemented and tested, which is shown to reduce the prediction error and training complexity, compared to an analytical or neural network learning model.
Micro-Ring-Resonator Based Passive Photonic Spike-Time-Dependent-Plasticity Scheme for Unsupervised Learning in Optical Neural Networks
Authors: Mesaritakis Charis , Skontranis Menelaos , Sarantoglou George , Bogris Adonis
Published: March 2020

In this work, a photonic spike-time-dependent-plasticity scheme based on high-order passive ring resonators is demonstrated. Numerical simulations confirmed the validity of the approach assuming post and pre-synaptic quantum dot laser neurons.
Combining Efficient Probabilistic Shaping and Deep Neural Network to Mitigate Capacity Crunch in 5G Fronthaul
Authors: Zhou Qi , Zhang Rui , Chen You-Wei , Shen Shuyi , Su Shang-Jen , Finkelstein Jeffrey , Chang Gee-Kung
Published: March 2020

We experimentally demonstrate a capacity-approaching transmission in 5G fronthaul utilizing PS-PAM8 and DNN. An 80-Gb/s over 20-km SSMF transmission performance is realized with a beyond 7.3-dB gross gain over uniform PAM modulations with linear post-equalization.
32-Channel WDM Transmitter based on a Single Off-the-Shelf Transceiver and a Time Lens
Authors: Lillieholm Mads , Xu Xiaoyu , Ekner Peter D. , Galili Michael , Oxenløwe Leif K. , Guan Pengyu
Published: March 2020

We demonstrate simultaneous WDM-signal generation using an optical time-lens and off-the-shelf components. 32 WDM-channels with 50-GHz spacing are generated from a single SFP+ transceiver source and received using another SFP+ after 50-km unamplified transmission.
High Efficiency, High Gain and High Saturation Output Power Quantum Dot SOAs Grown on Si and applications
Authors: Liu Songtao , Tong Yeyu , Norman Justin , Dumont Mario , Gossard Arthur , Tsang Hon K. , Bowers John
Published: March 2020

A high-performance quantum dot semiconductor optical amplifier directly grown on a CMOS compatible Si substrate is demonstrated to improve the receiver sensitivity in a filterless 60-Gbit/s NRZ transmission system over temperatures from 20°C to 60°C.
Analysis of 34 to 101GBaud submarine transmissions and performance prediction models
Authors: Antona Jean-Christophe , Meseguer Alexis Carbó , Dupont Sébastien , Garuz Richard , Plantady Philippe , Calsat Alain , Letellier Vincent
Published: March 2020

We analyze more than 100 subsea experiments with various configurations of rates, modulations, powers, reach and show a format and rate agnostic, accurate QoT prediction tool. We particularly show the impact of signal droop and the connection between GAWBS models based on spectral measurements and system impact.
Evaluation of Dynamic Skew on Spooled and Deployed Multicore Fibers Using O-Band Signals
Authors: Luís Ruben S. , Puttnam Benjamin J. , Rademacher Georg , Marotta Andrea , Antonelli Cristian , Graziosi Fabio , Mecozzi Antonio , Hayashi Tetsuya , Nakanishi Tetsuya , Shinada Satoshi , Awaji Yoshinari , Furukawa Hideaki , Wada Naoya
Published: March 2020

We compare fluctuations of propagation delay and inter-core skew on spooled and field-deployed multicore fibers. Our observations show a reduction of propagation delay fluctuations over deployed fibers but similar inter-core skew behavior.
100 Gbps PON L-band Downstream Transmission using IQ-MZM CD Digital Pre-Compensation and DD ONU receiver
Authors: Torres-Ferrera P. , Ferrero V. , Gaudino R.
Published: March 2020

We propose a downstream direct-detection 100G-PON solution aided by chromatic dispersion digital pre-compensation using an IQ-MZM, allowing L-band operation and 29 dB power budget with low ONU complexity and without requiring single-sideband modulation.
100-Gbit/s/λ PAM-4 signal transmission over 80-km SSMF based on an 18-GHz EML at O-band
Authors: Wang Kaihui , Zhang Jiao , Wei Yiran , Zhao Li , Zhou Wen , Zhao Mingming , Xiao Jiangnan , Pan Xiaolong , Liu Bo , Xin Xiangjun , Zhang Liwei , Zhang Yun , Yu Jianjun
Published: March 2020

For the first time, we experimentally demonstrate 100-Gbit/s PAM-4 signal transmission over 80km at O-band using an 18-GHz EML. After two spans of SOA-based 40-km SSMF transmission, a receiver sensitivity of −17.3dBm is achieved.
Interpretable Learning Algorithm Based on XGBoost for Fault Prediction in Optical Network
Authors: Zhang Chunyu , Wang Danshi , Song Chuang , Wang Lingling , Song Jianan , Guan Luyao , Zhang Min
Published: March 2020

We propose a fault prediction scheme using interpretable XGBoost based on actual datasets, which not only achieves high accuracy (99.72%) and low positive rate (0.18%), but also reveals the five most remarkable features that caused the fault.
FPGA Implementation of Prefix-Free Code Distribution Matching for Probabilistic Constellation Shaping
Authors: Yu Qinyang , Corteselli Steve , Cho Junho
Published: March 2020

We implement rate-adaptable prefix-free code distribution matching in an FPGA, demonstrating its real-time feasibility with substantially less hardware resources than low-density parity-check coding.
Theoretical Analysis and Experimental Measurement of Intra-LP-mode DMD in Weakly-coupled FMF
Authors: Zuo Mingqing , Ge Dawei , Shen Lei , He Yongqi , He Jin , Chen Zhangyuan , Li Juhao
Published: March 2020

Based on the analysis of intra-LP-mode DMD in weakly-coupled FMF, we propose a modified fixed-analyzer method for its measurement and experimentally demonstrate that it may be one of the major impairments for IM/DD MDM transmission.
Channel Dynamics in Few-Mode Fiber Transmission Under Mechanical Vibrations
Authors: Rademacher Georg , Ryf Roland , Fontaine Nicolas K. , Chen Haoshuo , Puttnam Benjamin J. , Luís Ruben S. , Awaji Yoshinari , Furukawa Hideaki , Wada Naoya
Published: March 2020

We experimentally investigate the coupling dynamics of a three-mode fiber recirculating transmission link under the influence of controlled mechanical vibrations. The dynamics are found to be more prominent compared to similar measurements in single-mode fiber.
Mode Group Resolved Analysis of Effects Induced by Macro Bending in a 50 µm Graded Index Multi Mode Fiber
Authors: Spenner Christian M. , Krummrich Peter M.
Published: March 2020

The influence of macro bending in a 50 µm GIMMF is investigated in terms of losses and mode coupling. The results indicate that lower order mode groups are weakly influenced by macro bends.
True Equalization of PDL in Presence of Fast RSOP
Authors: Cui Nan , Zhang Xiaoguang , Zhang Nannan , Tang Xianfeng , Xi Lixia
Published: March 2020

In presence of fast RSOP, a true PDL equalization including both signal power and OSNR balances is proposed and verified. With 1dB OSNR penalty, it can equalize up to 7dB PDL under 1Mrad/s fast RSOP.
On the Performance under Hard and Soft Bitwise Mismatched-Decoding
Authors: Yoshida Tsuyoshi , Mazur Mikael , Schröder Jochen , Karlsson Magnus , Agrell Erik
Published: March 2020

We investigated a suitable auxiliary channel setting and the gap between Q-factors with hard and soft demapping. The system margin definition should be reconsidered for systems employing complex coded modulation with soft forward error correction.
Rate-Adaptive Concatenated Polar-Staircase Codes for Data Center Interconnects
Authors: Mehmood Tayyab , Yankov Metodi P. , Fisker Anders , Gormsen Kim , Forchhammer Søren
Published: March 2020

A rate-adaptive concatenated code, consisting of an outer staircase code and an inner polar code is proposed. Short blocklength inner polar codes offers rate-adaptivity and more than 0.35 dB gain compared to the 400ZR data-center-interconnect error-correcting code.
Dual-Heterodyne Mixing Based Phase Noise Cancellation for Long Distance Dual-Wavelength FMCW Lidar
Authors: Pu Minglong , Xie Weilin , Zhang Ling , Feng Yuxiang , Meng Yinxia , Yang Jiang , Zhou Haijun , Bai Yuanshuo , Wang Tao , Liu Songhan , Ren Yan , Wei Wei , Dong Yi
Published: March 2020

A coherent dual-wavelength frequency-modulated continuous-wave (FMCW) lidar utilizing dual-heterodyne mixing which permits efficient phase noise cancellation has been proposed. Consistent ranging resolution about 1.4 × 10−6 over distances beyond tens of intrinsic coherence length is achieved.
Alignment Monitor for Free-Space Optical Links in the Presence of Turbulence using the Beating of Opposite-Order Orbital-Angular-Momentum Beams on Two Different Wavelengths
Authors: Zhang Runzhou , Hu Nanzhe , Su Xinzhou , Almaiman Ahmed , Song Haoqian , Zhao Zhe , Song Hao , Pang Kai , Liu Cong , Tur Moshe , Willner Alan E.
Published: March 2020

We experimentally demonstrate an approach for monitoring misalignment between transmitter and receiver for free space optical links under turbulence effects using the beating of two opposite-order orbital-angular-momentum beams on two different wavelengths.
10 GHz, 6.2 ps Transform-limited Coherent Optical Pulse Generation from a 1.55μm, Self-injection Gain-switched DFB-LD
Authors: Kasai Keisuke , Nakazawa Masataka
Published: March 2020

We demonstrate coherent optical pulse generation from a 1.55 μm, self-injection gain-switched DFB-LD. By using external spectral shaping, we generated a transform-limited 10-GHz, 6-ps Gaussian-pulse, which had neatly repetitive longitudinal modes with a 7 kHz-linewidth.
Low Parasitic Capacitance III-V/Si Hybrid MOS Optical Modulator toward High-speed Modulation
Authors: Li Qiang , Ho Chong Pei , Fujikata Junichi , Noguchi Masataka , Takahashi Shigeki , Toprasertpong Kasidit , Takagi Shinichi , Takenaka Mitsuru
Published: March 2020

We present advanced design of III-V/Si hybrid MOS optical modulator to reduce parasitic capacitance and resistance toward high-speed modulation. We successfully achieved 21 times smaller RC constant, improving the trade-off between modulation efficiency and bandwidth.
1000-nm IR Supercontinuum Due to Raman Soliton Supported by Four-Wave Mixing
Authors: Zajnulina Marina
Published: March 2020

Simple, low-cost, and robust telecom-fiber-based single-pass system is introduced and numerically studied to generate a supercontinuum ranging from 1500 nm to 2500 nm despite the optical loss due to infrared absorption in optical fibers.
Wavelength-tunable PT-symmetric single-longitudinal-mode fiber laser with a single physical loop
Authors: Dai Zheng , Fan Zhiqiang , Yao Jianping
Published: March 2020

A wavelength-tunable parity-time (PT)-symmetric single-longitudinal-mode fiber laser with a single physical loop is demonstrated. Single-longitudinal-mode lasing with a tunable range from 1549.2 to 1550.3 nm and a linewidth of 670 Hz is achieved experimentally.
A Frequency Digital Pre-distortion Compensation Method for FMCW LiDAR System
Authors: Chen Ting-Hui , Huang Chien-Ying , Shia Tim Kuei , Wun Sin-Jhu , Hsu Ching-Hsiang , Ku Kai-Ning , Lee Chi-Sen , Lin Chen-Yu , Chang Po-Chih , Wang Chung-Chih , Chen Shang-Chun , Lin Chien-Chung , Wu Chih-I
Published: March 2020

We propose a digital pre-distortion (DPD) compensation method for FMCW LiDAR system and demonstrate that the proposed method can enhance the ranging accuracy more than three times in our FMCW ranging experiment.
Experiments on Cloud-RAN Wireless Handover using Optical Switching in a Dense Urban Testbed
Authors: Minakhmetov Artur , Gutterman Craig , Chen Tingjun , Yu Jiakai , Ware Cédric , Iannone Luigi , Kilper Daniel , Zussman Gil
Published: March 2020

We investigate dynamic network resource allocation using software-defined networking optical controller with software-defined radios on the COSMOS testbed. 10 Gb/s capacity, deterministic low latency are maintained through user equipment wireless handover via optical switching.
Deterministic Layer-2 Ring Network with Autonomous Dynamic Gate Shaping for Multi-Service Convergence in 5G and Beyond
Authors: Shibata Naotaka , Kaneko Shin , Honda Kazuaki , Terada Jun
Published: March 2020

We propose autonomous dynamic gate shaping and rerouting according to real-time traffic-state for enhancing IoT-traffic throughput on deterministic Layer-2 network that also accommodates latency-sensitive mobile front-haul. System-level demonstrations show throughput improvement from 3.9Gbps to 7.9Gbps.
Few-subcarrier QPSK-OFDM wireless Ka-band delivery with pre-coding-assisted frequency doubling
Authors: Zhou Wen , Yu Jianjun , Zhao Li , Wang Kaihui , Kong Miao , Zhang Jiao , Chen You-Wei , Shen Shuyi , Chang Gee-Kung
Published: March 2020

We experimentally demonstrated a Ka-band dual/four-subcarrier QPSK-OFDM delivery over 25-km SMF and 1-m wireless link. To our knowledge, this is the first time to achieve few-subcarrier QPSK-OFDM signal generation and wireless transmission using pre-coding technique.
Centralized Digital Self-Interference Cancellation Technique to Enable Full-duplex Operation of Next Generation Millimeter Wave over Fiber Systems
Authors: Zhou Qi , Shen Shuyi , Su Shang-Jen , Chen You-Wei , Yao Shuang , Alfadhli Yahya , Chang Gee-Kung
Published: March 2020

We propose and experimentally demonstrate a centralized digital self-interference cancellation scheme in a mm-wave over fiber system for full-duplex next-generation mobile networks. A 24.1-dB self-interference cancellation over 1-GHz bandwidth is realized with successful signal-of-interest recovery.
Concept and Experimental Demonstration of Optical IM/DD End-to-End System Optimization using a Generative Model
Authors: Karanov Boris , Chagnon Mathieu , Aref Vahid , Lavery Domaniç , Bayvel Polina , Schmalen Laurent
Published: March 2020

We perform an experimental end-to-end transceiver optimization via deep learning using a generative adversarial network to approximate the test-bed channel. Previously, optimization was only possible through a prior assumption of an explicit simplified channel model.
Joint Linear and Nonlinear Noise Estimation of Optical Links by Exploiting Carrier Phase Recovery
Authors: Lippiatt Daniel , Varughese Siddharth , Richter Thomas , Tibuleac Sorin , Ralph Stephen E.
Published: March 2020

We demonstrate joint linear and nonlinear noise estimation by extracting the optical signal-to-noise ratio (OSNR) and launch power directly from phase noise metrics readily available within existing digital signal processing algorithms.
Secure Optical Communication Based on Common-Injection-Induced Synchronization of Wideband Complex Signals
Authors: Zhao Anke , Jiang Ning , Liu Shiqin , Zhang Yiqun , Qiu Kun
Published: March 2020

We propose and experimentally demonstrate a novel secure optical communication scheme that supports high encryption efficiency and high-speed transmissions over Gbit/s with satisfactory BER performance, by achieving common-injection-induced synchronization between two wideband complex entropy sources.
Disaggregated Packet Transponder field demonstration exercising multi-format transmission with multi-vendor, open packet optical network elements
Authors: Francia Geraldine , Nagase Ryoji , Ishida Wataru , Sone Yoshiaki , Kumar Lalit , Krishnamohan Srikanth , Lopez Victor
Published: March 2020

We demonstrate a field trial of 100G/200Gbps alien wavelength transmission and management onto a deployed line system (Telefónica del Perú nation-wide field network) with disaggregated packet transponder, adopting multi-vendor CFP2-ACO / CFP2-DCO transceivers.
First Proof That Geographic Location on Deployed Fiber Cable Can Be Determined by Using OTDR Distance Based on Distributed Fiber Optical Sensing Technology
Authors: Xia Tiejun J. , Wellbrock Glenn A. , Huang Ming-Fang , Salemi Milad , Chen Yuheng , Wang Ting , Aono Yoshiaki
Published: March 2020

We demonstrated for the first time that geographic locations on deployed fiber cables can be determined accurately by using OTDR distances. The method involves vibration stimulation near deployed cables and distributed fiber optical sensing technology.