bluuebunny/crossref_metadata_2025 huggingface dataset:
Directions for the development of the innovative potential of industrial enterprises
Authors: Kalendzhyan S. O. , Korkin M. A.
Published: October 2024

The article provides a comparative assessment of various scientists and economists studying theoretical approaches to sustainable strategic development of innovative potential of industrial enterprises. The conducted research identifies the main directions of the theoretical approaches to its study, both by Russian scientists and foreign ones. In this regard, it is necessary to pay more attention to the processes aimed at ensuring stable economic growth and, perhaps, even be unable to influence them. In the context of transforming global economic relations, the stability of economic systems is a key element of the development and strategic growth of the innovative potential of industrial enterprises. It is needed to introduce and use various theoretical approaches in the process of forming directions for the strategic development of this potential contributing to the effective establishment of the industrial complex. Methodological approaches of scientific research to the conceptual and essential characteristics and categorisation of the innovative potential of industrial enterprises as part of the economic system are also considered and systematised. The obtained results of the conducted research can be used in assessing the theoretical foundations aimed at studying the theoretical directions of industrial and spatial development of the country’s economic sectors and at the strategic development of the innovative potential of industrial enterprises.
Strategic development of the innovative potential of industrial enterprises
Authors: Vagin S. G.
Published: October 2024

The purpose of the article is to evaluate theoretical approaches to the study of various scientific and practical approaches of sustainable economic development. The author of the work has the following tasks: to conduct a comparative assessment of various scientists and economists studying theoretical approaches of sustainable strategic development of innovative potential of industrial enterprises; to identify the main directions of the theoretical approaches to its research of both Russian and foreign scientists; to determine the vectors of the strategic development of the innovative potential of companies in the industrial sector; to analyse and classify the methods that scientists use to study the essence and typology of the innovative potential of industrial enterprises within the economic system. Finally, the theoretical approaches to the study of the sustainable development of the innovative potential of enterprises of the regional industrial complex have been evaluated and used, the research results are formulated. The methods and techniques of application of various innovative technologies, ways, etc. are considered and evaluated. At the present stage of sustainable economic development this is of great importance. The results of the conducted research can be applied while formulating directions for the industrial and spatial development of the country’s economic sectors as well as for the strategic development of the innovative potential of industrial enterprises.
Ecosystem of structural and technological development: restarting growth of firms and entrepreneurial factor
Authors: Spitsin V. V. , Spitsina L. Yu. , Hasanov M. A. , Popova S. N.
Published: October 2024

The article examines the problem of structural and technological development of the Russian economy in conditions of an unfavorable external environment. In the context of the digital transformation of the economy at the micro level, several areas of the structural and technological development can be distinguished: generation of new business, accelerated development of successful (growing) enterprises, transition to restarting growth of enterprises that have been showing declining sales for a long time. The purpose of the work is to study the restarting growth of firms. The article assesses its economic results and also explores the influence of the entrepreneurial factor on the transition of enterprises to the restarting growth. The full sample consists of 2 918 enterprises that have been demonstrating a decline in revenue for a long time. This sample has been divided into groups of organisations that show and do not show the restarting growth. Using economic and mathematical methods, we have assessed the rate of revenue growth and examined the influence of the enterprise manager’s personality on the transition to the growth in the context of formed groups of companies. The paper has found that firms with the restarting growth show high rates of revenue growth that exceed its decline during the problematic period. The best results are demonstrated by a group of enterprises with the long-term rapid growth. Consequently, enterprises with the restarting growth can be considered as one of the options for the structural and technological development of the Russian economy along with the generation of new firms and development of growing enterprises. It has been proven that one of the growth factors is human capital, namely the head of the organization (entrepreneurial factor). Manager replacement has occurred more frequently in the group of enterprises with the long-term restarting growth compared to the group of enterprises that have not shown it. We believe that new leaders have initiated processes of digital and technological transformation of the business that lead to long-term growth.
Grand Canonical Monte Carlo and Deep Learning Assisted Enhanced Sampling to Characterize the Distribution of Mg2+ and Influence of the Drude Polarizable Force Field on the Stability of Folded States of the Twister Ribozyme
Authors: Baral Prabin , Sengul Mert , MacKerell Alex
Published: October 2024

Molecular Dynamics (MD) simulations are crucial for understanding the structural and dynamical behavior of biomolecular systems including the impact of their environment. However, there is a gap in timescale of these simulations and that of real-world experiments. To address this problem, various enhanced simulation methods have been developed. Additionally, there has been a significant advancement of the force fields used for simulations associated with the explicit treatment of electronic polarizability. In this study, we apply oscillating chemical potential grand canonical Monte Carlo and machine learning methods to determine reaction coordinates combined with metadynamics simulations to explore the role of Mg2+ distribution and electronic polarizability in the context of the classical Drude oscillator polarizable force field on the stability of the Twister ribozyme. The introduction of electronic polarizability along with details of the distribution of Mg2+ significantly stabilize the simulations with respect to sampling the crystallographic conformation. The introduction of electronic polarizability leads to increased stability over that obtained with the additive CHARMM36 FF reported in a previous study, allowing for a wider range of ions distribution to stabilize Twister. Specific interactions contributing to stabilization are identified included both those observed in the crystal structures and additional experimentally unobserved interactions. Interactions of Mg2+ with the bases are indicated to make important contributions to stabilization. Notably, the presence of specific interactions between the Mg2+ ions and bases or the non-bridging phosphate oxygens (NBPO), lead to enhanced dipole moments of all three moieties. Mg2+-NPBO interactions led to enhanced dipoles of the phosphates but, interestingly, not in all of the participating ions. The present results further indicate the importance of electronic polarizability in stabilizing RNA in molecular simulations and the complicated nature of the relationship of Mg2+-RNA interactions with polarization response of the bases and phosphates.
Synthetic intracellular nanostructures enhance cytotoxic T cell function via assembly-driven chemical engineering
Authors: Chagri Sarah , Burgstaller Anna , Schirra Claudia , Link Julian , Zhou Zhixuan , Roth Patrick , Meyer Raphael , Fetzer Jana , Ren Yong , Si Shutian , Mazzotta Francesca , Wagner Manfred , Lieberwirth Ingo , Landfester Katharina , Ng David Y.W. , Staufer Oskar , Weil Tanja
Published: October 2024

Nature achieves diverse biological functions through structure formation. Inspired by the controlled formation of polypeptide nanostructures in cells, synthetic methods have been developed to assemble artificial nanostructures and organelle-like compartments within living cells. While these synthetic intracellular assemblies have mostly been used to disrupt cellular processes, their potential to induce a gain of function within cells remains unexplored. Here, we introduce redox-sensitive isopeptides that transform into self-assembling linear peptides inside human cytotoxic T cells in response to intracellular levels of glutathione. The in situ formation of synthetic peptide nanostructures in cytotoxic T cells leads to cellular stiffening, establishing a direct interface between biochemically driven peptide assembly and mechanobiological effects. This change in biophysical properties, along with increased phosphorylation of signaling proteins associated with T cell activation, correlates with a significant enhancement in the efficacy of cytotoxic T cells to eliminate cancer cells. Our findings elucidate the cellular impact of synthetic peptide nanostructures assembled within living cytotoxic T cells and demonstrate their ability to modulate and enhance effector immune cell responses.
SpaceHASTEN: A structure-based virtual screening tool for non-enumerated virtual chemical libraries
Authors: Kalliokoski Tuomo , Turku Ainoleena , Käsnänen Heikki
Published: October 2024

Given the size of the drug discovery relevant chemical space, working with fully enumerated compound libraries (especially in 3D) is unfeasible. Non-enumerated virtual chemical spaces are a practical solution to this issue; where compounds are described as building blocks which are then connected by rules. One concrete example of such is the BioSolveIT chemical spaces file format (.space). Tools to search these space-files exist that are using ligand-based methods including, 2D fingerprint similarity, substructure matching, and fuzzier similarity metrics such as FTrees. However, there is no software available that enables the screening of these spaces using molecular docking. Here, a tool, called SpaceHASTEN, was developed on top of SpaceLight, FTrees, LigPrep, and Glide to allow efficient virtual screening of nonenumerated chemical spaces. SpaceHASTEN was validated using three public targets picked from the DUD-E dataset. It was able to retrieve a large number of diverse and novel high scoring compounds (virtual hits) from non-enumerated chemical spaces of billions of molecules, after docking a few million compounds. The software can be freely used and is available from http://github.com/TuomoKalliokoski/SpaceHASTEN. Keywords:
Educación intercultural desde el pensamiento decolonial. Resistencias y desafíos.
Authors: Battestin Cláudia
Published: October 2024

Este libro fue tejido desde el trabajo y convicción de una red de diálogo con personas de distintas partes del Sur Global, con el deseo de fortalecer e intercambiar experiencias, investigaciones, conocimiento y esperanzas. El diálogo entre el Centro de Investigación Iberoamericano de Educación (CIIEDUC) y la Red Latinoamericana de Diálogos Decoloniales e Interculturales (REDYALA), surge con o desafío de cruzar redes, lugares, personas, movimientos y distintas realidades para presentar movimientos de resistencia, estudios, trabajos, colectivos, investigaciones, y liderazgos que se constituyen desde el sur, de nuestra Abya Yala.
Oral Anti-Coagulant (Acitrom) Induced Coagulopathy - A Case Report
Authors: J Sreelatha , Sandhya M , Aby Bija , Cleetus Reshma , Shabaz Shaikh , Damarla Nagarjuna
Published: October 2024

The major complication of oral anticoagulants is bleeding. Acitrom Acenocoumarol an oral anticoagulant is similar to Warfarin but has a longer half-life with fewer interactions. To reduce the risk of these complications the Prothrombin time PT ndash usually expressed as the International Normalized Ratio INR is used to monitor the degree of Acenocoumarol or coumarin-associated anticoagulation. In our study a 50 year old male patient presented with a complaint of ecchymosis over abdomen and thigh and hematuria since five days. The patient was on T. Acitrom 4 mg with a history of open-heart surgery 20 years back. On analyzing the subjective and objective evidences the condition was diagnosed as lsquoAcitrom Induced Coagulopathyrsquo which was confirmed using WHO-UMC Uppsala Monitoring Centre Causality Assessment Scale Naranjo Scale Score and Karch and Lasagna scale.
Solubility Behaviour of Aripiprazole in Different Solvent Systems
Authors: Sambhakar Sharda , S Kamath K Shwetha , J Thimmasetty , Nayak N Shashank , Singh Bishambar , Das Paramita
Published: October 2024

Background This current research work discusses the Aripiprazolersquos solubility behaviour in individual solvents and solvent blends to offer some theoretical foundation for the formulation scientists regarding solute solvent interactions. AimsObjectives Solubility behaviour of Aripiprazole a poorly soluble drug was studied using biocompatible solvents like polyethylene glycol 400 PEG-400 ethanol propylene glycol PG glycerin and pharmaceutically utilized solvents such as dioxane hexane and ethyl acetate in pure form and their blends. Methods Saturation solubility of Aripiprazole was studied by placing the drug in excess solvent systems using cryostatic constant temperature shaker bath for 72 hours. The solutions after equilibrium were analyzed spectrophotometrically.Results Physico-chemical characteristics of the solvents and Aripiprazole such as intermolecular interactions hydrogen bonding hydrophobic interactions and certain specific solute solvent interactions were noticed for enhanced aqueous solubility AS of Aripiprazole.Conclusion Less polar solvents were shown to significantly increase AS highlighting the hydrophobic interaction strategy. The order of cosolvents increasing AS of Aripiprazole was PEG 400 gt dioxane gt ethylacetate gt ethanol gt PG gt glycerin gt hexane. Based on the data specific combinations were shown to be helpful in the production of Aripiprazole injections and liquid orals. As a result the study produced a significant dataset for comparing how different cosolvents affected the solubility of Aripiprazole and how Aripiprazole formulations were designed.
The Guarantee Measures of Educational Rights on the Traditional Communities of Southwest Papua
Authors: Markus Dwi P , Mahmudah Masrifatun , Arya Surandi Wong , Yati Sri
Published: October 2024

This research aims to know the guarantee measures of educational rights, and analyse its from custom law. This research is empirical study that uses field data as primary data sources. Data collection techniques were carried out from interviews, observation and documentation. The result show that absorption of at least 30% of the budget income and expenditure areas that must be absorbed by education No appropriate target, the spelled out small if compare with budget income and to much expenditure area and must capable to accommodate cost of school for 203 Papuan children. This all based on government programs as well not yet appropriate and take the good target. It should check again on many factors and reason that show many separated Papuan school and different area, distance and difficult geological area which impact to the student and decide not to continue their education including economic factor.
The Legality Questioning of the Investigation Termination Through the Investigation Warranty on Corruption Crime
Authors: Silambi Erni Dwita , Tajuddin Mulyadi Alrianto , Rado Rudini Hasyim , Y. Badilla Nurul Widhanita
Published: October 2024

The ongoing investigation sheds light on a criminal case. The purpose of this study is to analyze the legality of the termination of the investigation of corruption cases carried out by the KPK as a result of the enactment of Article 40 of Law No. 30 of 2002. This research focuses on the authority of the KPK in stopping the investigation process of corruption crimes through the Investigation Termination Order (SP3). With the type of normative juridical-based research, the research is centered on literature research taken from the study of the election, literature studies, and other scientific works then analyzed using qualitative research methods that are oriented to the conceptual certainty approach and the case approach. The main problems found include the legality of SP3 by the KPK in corruption crimes. The results of the study show the position of the KPK as a super body institution, in the enforcement of corruption crimes, it has several special authorities because it is regulated in a specialist manner in its own provisions, including the authority to investigate based on philosophical, sociological, and juridical aspects, where the essence of the KPK's authority is a rational effort in eradicating corruption and realizing law enforcement oriented towards justice and legal certainty. The recommendation given is that investigations and investigations by the KPK must be carried out professionally, efficiently, and effectively by paying attention to the conditions that must be met before the investigation is carried out, so that synergy and coordination between law enforcement officials are needed.
Is the Post-Reformation System of the Indonesian Government a Parliamentary Form?
Authors: Sinaga Parbuntian , Machmud Aris
Published: October 2024

Indonesia's democratic government system has experienced ups and downs based on history, where at the beginning of independence Indonesia used a presidential system, then changed to a parliamentary and then returned to a presidential system. The reformation period was a milestone in changing the government system where previously the president was elected by the MPR as the highest state institution to switch to direct presidential elections carried by a party or a coalition of parties - due to the existence of regulation on the threshold for nomination (parliamentary threshold) - but to maintain the implementation of the presidential campaign promise to establish a coalition of parties supporting the government which has an impact on the role of the People^s Representative Council only as a stamp of government interests. The problem in this study is how the presidential system exists in the post-reform Indonesian government system. The form of the research method used is normative juridical with a statutory approach and an analytical descriptive approach that examines primary and secondary legal materials, besides examining the synchronization and harmonization of law. The conclusion is that the current Indonesian government system tends to be parliamentary. This is due to the weak bargaining position of the DPR in supervising the running of government because the majority of DPR members are supporters of the government, while the opposition forces are unequal with the majority, which prioritizes the most voting system over consensus deliberation for the benefit of the people. so that checks and balances - separation of powers - turned into a division of powers - dividing power.
The Concept of Restorative Justice in the Criminal Legal System: A Breakthrough in Legal Benefits
Authors: Walim Walim
Published: October 2024

Historically, alternative efforts to resolve criminal cases have existed since the Dutch colonial era, even before Indonesia's independence. Currently, there are several forms of resolving criminal cases outside of court in force, namely diversion (transferring the resolution of children's cases from the criminal justice process to a process outside criminal justice in accordance with the Juvenile Criminal Justice System Law), Afkoop (as regulated in Article 82 of the Criminal Code), and Seponeren (dismissal of cases in the public interest by the Attorney General). The aim of this research is to analyze the concept of restorative justice in the criminal law system as a breakthrough in legal benefits. Approach The research method that can be used in this research is the empirical juridical approach. This approach combines a normative juridical approach with an empirical approach. Based on the analysis carried out, restorative justice can be applied in cases that cause financial loss or minor crimes. The principle of restorative justice in resolving criminal cases in Indonesia does not only depend on formal and material criminal law provisions but is also based on a broader concept of punishment. The model for implementing restorative justice in Indonesian criminal procedural law can be found through a criminal resolution mechanism that follows a legitimate legal problem resolution approach, which is reflected in the reform of the criminal justice system in Indonesia, which is based on an evaluation of the criminal justice system.
Child Life through the Lens of Family Stress Theory and Family Systems Theory
Authors: Insley Annie N. , Sheaffer Erika N.
Published: October 2024

Certified Child Life Specialists (CCLS) are an integral part of the healthcare team, who address children and families’ psychosocial needs and help children and families cope throughout their healthcare experiences. The history of child life, description of the interventions provided by Certified Child Life Specialists, and educational preparation needed for child life certification will be discussed. Certified Child Life Specialists use family science theories in their interventions with patients and families. Two of the family science theories that influence assessments and interventions are family stress theory (Boss, 1988; Hill, 1949; McCubbin & Patterson, 1983) and family systems theory (Smith & Hamon, 2022). Certified Child Life Specialists utilize these theories to provide support to families and create resources for positive coping and adjustment to their hospital experience. These theories will be discussed, and case studies will be examined to illustrate how Certified Child Life Specialists integrate these theories into their practice.
Utilizing Family Theories to Maximize Early Intervention Work: An Examination and Application of Family Systems Theory and Bioecological Theory
Authors: Cook J. Claire , Oldham Rebecca , Casha Connie , Franklin Jenny
Published: October 2024

The field of early intervention is rapidly expanding. Individuals trained in Human Development and Family Science programs are uniquely situated for work in this setting, due to their diverse understanding of human development, from birth through death, and the role of the family system in influencing development. More specifically, individuals from this academic discipline can employ a family systems theory and bioecological theory perspectives to inform their intervention work. The unique insight these theories provide to enhance early intervention work will be discussed and then applied using an actual case study. Though family systems theory and bioecological theory do have limitations in this field, namely their inability to explain a behavioral change and non-linear orientation, the authors feel the benefits of both these theoretical perspectives for explaining family contexts outweigh the limitations.
The Effects of Hydrothermal Temperatures on ZnO-Bentonite Composite Synthesis on Adsorption and Photodegradation of Methylene Blue Dye
Authors: Zulkarnain  , Hakim Yusuf Mathiinul , Melwita Elda , Mohadi Risfidian
Published: October 2024

This study explores the influence of hydrothermal temperatures on the synthesis of ZnO-Bentonite composites and their efficiency in the adsorption and photodegradation of Methylene Blue dye. ZnO nanoparticles were integrated into Na-Bentonite, with composites synthesized at hydrothermal temperatures of 100°C and 200°C. Various characterization techniques such as XRD, FTIR, UV-Vis DRS, TG-DTA and BET were utilized to analyze the structural and thermal properties. The results show that the composite synthesized at 200°C exhibits superior performance, with a maximum adsorption capacity of 120.48 mg/g at 50°C, significantly higher than the 49.26 mg/g achieved by the composite synthesized at 100°C. Moreover, the enhanced crystallinity and increased surface area, as evidenced by a 16 nm crystallite size at 100°C and 22 nm at 200°C, led to improved photocatalytic activity. The research concludes that higher hydrothermal temperatures improve both adsorption and photodegradation efficiency, making the composite synthesized at 200°C more effective for environmental applications.
Enhanced Anti-Inflammatory Activity of Kaempferia galanga Extract by Solid Self-Nanoemulsifying Drug Delivery System and Its Development in Fast Disintegrating Tablet
Authors: Latifani Salma , Fitriani Annisa nur , Paniroy  , Maesayani Kadek Sanitha , Freddy Juan , Adianingsih Oktavia Rahayu
Published: October 2024

The increasing global incidence of osteoarthritis (OA) emphasizes the need for effective treatments, particularly for the elderly. Conventional OA treatments pose administration challenges, leading to patient discomfort due to difficulties in administration. Herbal formulations offer an alternative to mitigate these issues. Kaempferia galanga (KG) contains ethyl p-methoxycinnamate, a compound displaying anti-inflammatory properties that hold promise for OA treatment. This study explores the formulation of a solid self-nanoemulsifying drug delivery system (S-SNEDDS) of Kaempferia galanga extract (KGE) and evaluates its anti inflammatory efficacy, subsequently developing it into a fast disintegrating tablet (FDT) dosage form. Initially, a liquid SNEDDS (L-SNEDDS) was prepared with varying surfactant and co surfactant concentrations. The optimal formula of L-SNEDDS (FL2) using tween 80: cremophor RH 40: PEG 400 in a ratio of 1:1:2 demonstrated favorable characteristics, including transmittance of 86.93 ± 1.16%, emulsification time of 28 ± 2.65 s, particle size of 27.79 ± 2.00 nm, PDI of 0.21 ± 0.014, and zeta potential of -12.57 mV. FL2 was solidified using aerosil 200 to produce S-SNEDDS and tested for anti-inflammatory efficacy in vivo using a carrageenan induced rat model. Results showed enhanced anti-inflammatory efficacy of KGE via S-SNEDDS, marked by reduced edema volume. Afterward, FDT S-SNEDDS were prepared using the direct compression method by comparing different types of superdisintegrants. The formulation using the combination of crospovidone and croscarmellose sodium (FT2) demonstrated excellent flow properties, tablet disintegration time of 63 s, wetting time of 34.01 ± 7.87 s, friability of 0.19%, and hardness of 3.53 ± 6.16 kg/cm2. The dissolution test indicated a better dissolution profile for FT2 compared to other formulations. In conclusion, this research presents the potential of FDT S-SNEDDS as a promising drug delivery system for enhancing the therapeutic effects of Kaempferia galanga extract in treating inflammatory conditions such as osteoarthritis.
Analysis of Structure, Morphology, Magnetic Properties, and Microwave Absorption of Lanthanum Orthoferrite (LaFeO3)
Authors: Naibaho Marzuki , Widakdo Januar , Kurniawan Budhy , Nehan Phahul Zhemas Zul , Vitayaya Okvarahireka , Novita  , Ramlan  , Adi Wisnu Ari , Ginting Masno
Published: October 2024

LaFeO3 has been prepared using the solid-state reaction method with High Energy Milling (HEM). The preparation of LaFeO3 was carried out using stoichiometric calculations. Based on the XRD measurement results, single-phase LaFeO3 with an orthorhombic crystal structure was obtained. From the SEM results, the morphology of LaFeO3 is uniform, and the EDS results show the weight percentage of La, Fe, and O elements are 49.74, 21.08, and 29.18 wt%, respectively. VSM LaFeO3 results show magnetic saturation, remanence, and coercivity are 0.24 emu/g, 0.02 emu/g, and 853.38 Oe, respectively, and the absorption of LaFeO3 is -7.40 dB at a frequency of 6.02 GHz with a LaFeO3 sample thickness of 1.5mm.
Thermal Conversion of Coral Waste and its Utilization as Low-Cost Catalyst for Biodiesel Production
Authors: Widianingsih Suci , Yanti Ika , Kamari Azlan , Fatimah Is
Published: October 2024

This study investigates the thermal conversion of waste coral and its utilization as a heterogeneous catalyst for biodiesel production from soybean oil. In this work, waste coral is calcined at varied temperatures of 800, 900, and 1000°C, and the effect of the calcination temperature on the physicochemical character of the solid is evaluated through Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and basicity measurement. The results show that the higher temperature facilitates the conversion of CaCO3 of the aragonite and calcite phases in raw waste coral into CaO, achieving a complete conversion at the temperature of 1000°C. Thermal conversion influences the increased surface basicity of the solid, which is associated with the higher activity for biodiesel production. Further studies on the obtained CaO as a catalyst demonstrate the catalyst dosage and the methanol-to-oil ratio as significant factors for fatty acid methyl ester production. The highest yield of 98.7% is achieved after a 3 hours reaction with 8 wt.% catalyst dosage and 9:1 methanol-to-oil ratio. The catalyst exhibits stability with an insignificantly decreased yield until the fifth usage cycle. The optimum conditions and reusability features of the calcined waste coral suggest that waste coral is a favorable CaO catalyst source for biodiesel production.
Synthesis and Characterization of Ni(II) Schiff Base Complex as a Precursor for NiO Nanoparticles and an Investigation of Their Corrosion Inhibition
Authors: Raji Shahad Qasim , Bader Ali Talib
Published: October 2024

This study first aimed to synthesize and characterize a [Ni(C14H13NO2)(OAC)2(H2O)2] via the preparation of a ligand, coordination with Ni(II) ions, and full characterization, such as "FTIR, 1H and 13C-NMR, UV-Visible spectroscopy; and ESI-mass spectrometry" The Nickel complex was then used as a precursor to prepared NiO Nps by calcination at 450°C. The phase purity, crystalline structure, and morphological characterizes of the NiO nanoparticles were investigated via X-ray diffraction (XRD), FESEM, and FTIR spectroscopy, revealing them to be cubic system with an average crystalline is 26 nm. The preparation technique is facile, cost-effective, and rapid and suitable for generating NiO nanoparticles for use in industrial processes. Further, the corrosion inhibition effectiveness of all synthesized compounds on mild steel in 1 M HCl was evaluated. Their inhibition efficiencies were determined via potentiodynamic polarization studies, revealing the highest inhibition efficiency for the NiO nanoparticles compared to the Nickel complex and free a ligand.
Phytoestrogens Therapy for Osteoporosis Treatment Using Indonesian Medicinal Plants: A Brief Review
Authors: Sianipar Rut Novalia Rahmawati , Iswantini Dyah , Charlena Charlena , Wahyudi Setyanto Tri , Prasetyo Joni
Published: October 2024

A problematic bone remodeling cycle is known to produce more osteoclasts than osteoblasts, making bones more fragile and this condition shows osteoporosis. In this context, estrogen deficiency in the human body is associated with the regulation of osteoporosis. Therefore, this study aimed to investigate the knowledge about basic concepts of bone, osteoporosis, phytoestrogens, and Indonesian medicinal plants for osteoporosis treatment. Data were obtained from literature on various databases including Science Direct, Wiley Online Library, Scopus, Pubmed, and Google Scholar. Adequate therapy is needed to increase estrogen content and an effective approach is to consume medicinal plants that contain phytoestrogens, which have identical structure and activity to human estrogen (17β-estradiol). The results showed that there were observations comprising in vitro, in vivo, and in silico studies on 18 Indonesian medicinal plants as antiosteoporosis treatments. The Leguminosae or Fabaceae family, which has a significant amount of isoflavones (the primary group of phytoestrogens) was found to dominate as an antiosteoporosis agent. Therefore, the development of phytoestrogens therapy from Indonesian medicinal plants must be implemented for the future treatment of osteoporosis.
Correlation Mineral Water Consumption and Hemoglobin Levels in Adolescent Girls
Authors: Putri Gela Setya Ayu , Maolida Nurul , Sukeksi Andri
Published: October 2024

Anemia is a global health issue that affects people of all ages, particularly adolescent girls. Adolescent girls require nutritional intake, both from food and water. According to the balanced nutrition guidelines, people (particularly adolescents and adults) require 2000 liters (or eight glasses) of water daily. Most adolescent girls barely consider their water consumption. A lack of water in the body affects the balance of minerals (salt and sugar), disrupting regular metabolic processes such as hemoglobin (Hb) level regulation. This study investigates the correlation between adolescent girls' water consumption and hemoglobin levels. This quantitative study uses a cross-sectional design to collect variable data at a certain time. The study used blood with anti-coagulants EDTA from 30 adolescent girls from Universitas Muhammadiyah Semarang. The primary data for this study are water consumption and hemoglobin levels. Results of the research show that adolescent girls' water consumption was adequate (66.7%) and low (33.3%). The average Hb level among adolescent girls was 12.4 g/dL. Adequate water consumption resulted in 3 respondents with low Hb levels and 7 with normal Hb levels. In contrast, low water consumption resulted in 2 respondents with low Hb levels and 18 with normal Hb levels. The Rank-Spearman correlation test showed sig 0.177 (p>0.05). The study concluded that there was no correlation between adolescent girl water consumption and hemoglobin levels. Food fluid intake can compensate for a lack of water consumption.
The Application of Semantic Cognitive Mechanism of English Idioms in Idiom Teaching
Authors: Zhan Haiying
Published: October 2024

This article takes the perspective of cognitive linguistics and applies the semantic cognitive mechanism of English idioms to analyze the motivation between the generation and meaning of idioms. It explores the teaching of English idioms based on motivation analysis and proposes several suggestions and strategies for idiom teaching, hoping to benefit English idiom teaching.
Design and Application of “STEM+” 6E Teaching Mode in Information Technology Teaching
Authors: Zhang Yu , Lan Xiaohong , Lu Yaqing , Deng Ying
Published: October 2024

The concept of “STEM+” integrates art, humanistic literacy, and social values in the traditional STEM education concept, advocates cross-disciplinary integration, and aims to cultivate compound talents equipped to tackle future challenges. In 2022, the Ministry of Education issued the “Compulsory Education Information Technology Curriculum (2022 Edition),” emphasizing the core literacy of information science and technology and the integration of interdisciplinary disciplines, and encouraging the teaching mode suitable for discipline characteristics. The 6E teaching mode is a student-centered teaching strategy characterized by active exploration and cross-disciplinary integration. This article innovatively designed the “STEM+” 6E teaching mode, which is applied to junior high school information technology teaching, which can better achieve core literacy teaching goals.
The Impact of Contextual Teaching Method on Sichuan Folk Song Education and Students’ Musical Expressiveness
Authors: Li Jing
Published: October 2024

This study explores the application of the contextual teaching method in Sichuan folk song education and its impact on students’ musical expressiveness. By incorporating contextual teaching methods in music classes, this research investigates the effectiveness of this approach in enhancing students’ understanding of Sichuan folk songs and improving their musical expressiveness and emotional expression. A mixed-method research approach is employed, utilizing classroom observations, questionnaires, interviews, and statistical analysis to assess the practical outcomes of contextual teaching in folk song education.
Exploration of University English Teachers’ Acceptance and Willingness to Use Learning Management System Data Analysis Tools
Authors: Yao Xiaochao
Published: October 2024

This study investigates university English teachers’ acceptance and willingness to use learning management system (LMS) data analysis tools in their teaching practices. The research employs a mixed-method approach, combining quantitative surveys and qualitative interviews to understand teachers’ perceptions and attitudes, and the factors influencing their adoption of LMS data analysis tools. The findings reveal that perceived usefulness, perceived ease of use, technical literacy, organizational support, and data privacy concerns significantly impact teachers’ willingness to use these tools. Based on these insights, the study offers practical recommendations for educational institutions to enhance the effective adoption of LMS data analysis tools in English language teaching.
Exploration and Practice of Integrating Ideological and Political Education into the “Comprehensive Practical Training in Prefabricated Building Construction” Course
Authors: Yang Chunhui
Published: October 2024

This paper focuses on the ideological and political construction of the course “Comprehensive Practical Training of Prefabricated Building Construction” and deeply discusses its exploration and practice process. By building an ideological and political teaching system in line with the characteristics of “Comprehensive Training of Prefabricated Building Construction,” ideological and political elements such as industry spirit, professional ethics, and social responsibility are organically integrated into all links of practical training and teaching. In terms of teaching methods, various innovative means such as case analysis, role-playing, and group discussion are adopted, and modern information technologies such as virtual reality and augmented reality are used to improve the teaching effect. At the same time, a diversified teaching evaluation system is formulated to ensure the sustainability and effectiveness of ideological and political education. This study not only enriches the theoretical research of ideological and political courses but also provides a practical reference for the ideological and political construction of similar courses, which is of great significance for promoting the overall improvement of the quality of talent training in higher education.
Research on Mechanisms for University Connotation Construction and High-Quality Employment in the Context of New Quality Productivity
Authors: Meng Shouwei , Meng Wenyuan
Published: October 2024

The introduction of the concept of new quality productivity has attracted a great deal of attention in the educational community. However, there is an urgent need to align it with policy orientation and advancements in science and technology moving forward. Colleges and universities themselves should be the leaders of advanced thinking and scientific and technological development, and play their due roles in line with the development of the times to provide quality and urgent talents and intellectual support. For this reason, this paper proposes that universities should consciously establish a set of regular operation mechanisms, namely, the linkage mechanism between “social demand” and “connotation construction,” and operate regularly under the guarantee of the system. This enables universities to lead or grasp the pulse of scientific and technological development, constantly improve the level of connotation construction, promote high-quality employment, and provide high-quality services for modernization and the great rejuvenation of the Chinese nation.
An Analysis of the Musicality of Yong Liu’s Yulinling: Farewell in Autumn Based on the Perspective of Language Musicology
Authors: Wang Hongtao , Shengchuan Ruiji
Published: October 2024

From the perspective of linguistic musicology, this paper discusses the musical features of Yulinling: Farewell in Autumn, a representative work of Yong Liu, a famous lyricist of the Song Dynasty. Through a systematic analysis of the core elements of the poem, such as rhyme, timbre, key, and rhythm, it reveals the intrinsic connection between poetry and music and proposes a new way of thinking about the modern interpretation of ancient poetic songs. This paper not only enriches the understanding of Yong Liu’s works but also provides new theoretical support for modern music education of classical poetry. In addition, this paper explores the practical application value of poetic musicality analysis in cultural inheritance and modern adaptation of classical poems, providing new insights into the contemporary inheritance of cultural heritage.
The Procedure of an International Student Studying Abroad: A Case Study
Authors: Xiao Ying
Published: October 2024

As it is examined and concluded by many researchers, studying abroad has been common when students are trying to receive higher quality education. Cross-cultural adjustment is also regarded as a compulsory term to consider, and the way to get involved in the host culture has also been deeply investigated in this procedure. Therefore, this paper aims at identifying the factors that cause cultural barriers, as well as finding solutions to cope with them. In this study, a case study research method is employed and the result will be beneficial to support future research in similar fields.
A Study on Aligning Nursing Curriculum with Hospital Clinical Competency Requirements
Authors: Li Xuemei , Tayag Jarrent
Published: October 2024

The purpose of this study is to coordinate the alignment between the nursing curriculum and hospital clinical competencies, identify the reasons for the gaps, evaluate the impact of these gaps on the nursing profession, and propose strategies to bridge these gaps. This study will help strengthen nursing education, improve nursing students’ skills, and help students adapt to complex clinical environments.
Comparative Perceptions Influence Actions on Climate Change Between Eastern and Western Europeans
Authors: Koompai Somjintana , Royer Joël , Pathak Shubham
Published: October 2024

Climate change is an important issue that countries worldwide are aware of and campaign to reduce. All parties must cooperate, whether the government, the private sector, individuals, etc. Many perception surveys have met the public's understanding and knowledge about climate change. Despite the odds, previous research supported environmental protection and sustainability in surveys, polls, and past research. However, the existing literary gap between intentions and actions and awareness and implementation has recently widened. The objectives of this research include comparing perceptions and climate change mitigation actions between Eastern and Western European countries because both regions are different, as well as searching for and comparing perceptions influencing climate change mitigation actions between them. The research adopts a quantitative methodology, emphasizing exploring secondary data from the European Investment Bank (EIB) climate change survey 2022–2023. It analyzed the data to compare the perceptions and actions of the two regions in mitigating climate change. The statistical tests included a t-test and stepwise multiple regression analysis to predict the influence of perceptions and actions on reducing climate change. The results showed that respondents' perceptions of climate change in Eastern and Western Europe were not significantly different. However, there was a significant difference in the number of reduction actions taken by Western Europeans compared to Eastern Europeans. Perceptions of climate change catastrophes and serious government mitigation actions positively influenced actions in Eastern Europe. This study found that businesses' attention to mitigation and their perception of the catastrophic effects of climate change positively influence mitigation actions in Western Europe. The recommendations guided governments, policymakers, and businesses to take action to reduce climate change, motivating people's adequate perceptions and actions. Stakeholders communicating climate change's impacts on catastrophe should present true information with honesty and transparency. Doi: 10.28991/HEF-2024-05-03-03 Full Text: PDF
The effectiveness of various approaches in the treatment of peripheral neuropathies in people with type 2 diabetes mellitus
Authors: Stefanenko A. V. , Bagriy A. E. , Orekhova A. O. , Efremenko V. A. , Mikhailichenko E. S. , Suprun E. V. , Rebrova S. A. , Stefanenko E. R.
Published: October 2024

Introduction. Optimal therapeutic tactics for diabetic peripheral neuropathy (DPN) can reduce the risk of complications and improve the quality of life of patients with diabetes mellitus (DM).

Aim: To evaluate the effectiveness of various approaches to the treatment of DPN.

Materials and Methods. 67 patients were examined (36 men and 31 women, mean age 59.4 ± 9.7 years), duration of diabetes was at least 7 years. Patients underwent general clinical examinations, neurological examination and diagnosis of DPN with assessment of pain, tactile and vibration sensitivity. All patients underwent ultrasound of the peroneal nerve (PN): the structure and cross-sectional area (CSA) were assessed (≤ 11 mm2 was taken as the norm). Patients with symptoms of PN compression received mini-invasive treatment by perineural administration of 20 mg methylprednisolone under ultrasound control.

Results. Clinical manifestations of DPN were identified in 33 (49.3%) cases. Changes in ultrasound PN occurred in 62 (92.5%) patients. 29 patients with echographic changes in PN and asymptomatic DPN received α-lipolic acid and benfotiamine: the CSA of the PN before treatment was 13,2 ± 2,4 mm2, after 6 months –10,4 ± 1,6 mm2; the proportion of people with CSA PN ≥ 12 mm2 before treatment was 82,7%, after 6 months –27,6% (all p < 0.05). 19 patients with symptoms of DPN, but without signs of compression of the MBN, received additional drugs and techniques. The average pain intensity before treatment was 4,93 ± 1,07, after 6 months –2,47 ± 0,61; CSA PN before treatment –17,3 ± 3,8 mm2, after 6 months –13,2 ± 2,2 (all р < 0,017). 14 patients with PN compression underwent mini-invasive treatment under ultrasound control. In the first 24–48 hours after manipulation, in all cases there was a moderate increase in local manifestations of compression. Then the pain intensity decreased (5.74 ± 1.19 points – before manipulation, 3.18 ± 0.97 – after 6 months, р < 0,0125), CSA decreased (22.4 ± 4.3 mm2 – to 15.3 ± 3.6 mm2 – after 6 months, р < 0,0125) and echographic characteristics improved.

Conclusions. Ultrasound of the nerves can be a valuable method for the early diagnosis of DPN and a tool for choosing treatment tactics. The use of pathogenetic pharmacotherapy alone or in combination with other drugs was associated with satisfactory tolerability, favorable clinical and ultrasound dynamics. The use of mini-invasive treatment with perineural administration of drugs for compartment syndrome was characterized by a positive effect on compression symptoms and ultrasound characteristics of the nerve.
General characteristics of spiritual and moral values as an object of legal protection
Authors: Kozlova Anastasiya
Published: October 2024

The article is devoted to the consideration of spiritual and moral values as a special object in need of legal protection in modern conditions and receiving such protection. Various approaches to the definition of the concept of "spiritual and moral values" are analyzed. It is explained why, since the approval of the Foundations of state Policy for the Preservation and strengthening of traditional spiritual and moral values, many legal scholars, arguing about spiritual and moral values, rely on the normative definition of the concept of "traditional values". The author's definition of the concept of "spiritual and moral values" is formulated.