bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Tables 1 - 4 from Large-Scale Evaluation of Common Variation in Regulatory T Cell–Related Genes and Ovarian Cancer Outcome
Authors: Charbonneau Bridget , Moysich Kirsten B. , Kalli Kimberly R. , Oberg Ann L. , Vierkant Robert A. , Fogarty Zachary C. , Block Matthew S. , Maurer Matthew J. , Goergen Krista M. , Fridley Brooke L. , Cunningham Julie M. , Rider David N. , Preston Claudia , Hartmann Lynn C. , Lawrenson Kate , Wang Chen , Tyrer Jonathan , Song Honglin , deFazio Anna , Johnatty Sharon E. , Doherty Jennifer A. , Phelan Catherine M. , Sellers Thomas A. , Ramirez Starr M. , Vitonis Allison F. , Terry Kathryn L. , Van Den Berg David , Pike Malcolm C. , Wu Anna H. , Berchuck Andrew , Gentry-Maharaj Aleksandra , Ramus Susan J. , Diergaarde Brenda , Shen Howard , Jensen Allan , Menkiszak Janusz , Cybulski Cezary , Lubiński Jan , Ziogas Argyrios , Rothstein Joseph H. , McGuire Valerie , Sieh Weiva , Lester Jenny , Walsh Christine , Vergote Ignace , Lambrechts Sandrina , Despierre Evelyn , Garcia-Closas Montserrat , Yang Hannah , Brinton Louise A. , Spiewankiewicz Beata , Rzepecka Iwona K. , Dansonka-Mieszkowska Agnieszka , Seibold Petra , Rudolph Anja , Paddock Lisa E. , Orlow Irene , Lundvall Lene , Olson Sara H. , Hogdall Claus K. , Schwaab Ira , du Bois Andreas , Harter Philipp , Flanagan James M. , Brown Robert , Paul James , Ekici Arif B. , Beckmann Matthias W. , Hein Alexander , Eccles Diana , Lurie Galina , Hays Laura E. , Bean Yukie T. , Pejovic Tanja , Goodman Marc T. , Campbell Ian , Fasching Peter A. , Konecny Gottfried , Kaye Stanley B. , Heitz Florian , Hogdall Estrid , Bandera Elisa V. , Chang-Claude Jenny , Kupryjanczyk Jolanta , Wentzensen Nicolas , Lambrechts Diether , Karlan Beth Y. , Whittemore Alice S. , Culver Hoda Anton , Gronwald Jacek , Levine Douglas A. , Kjaer Susanne K. , Menon Usha , Schildkraut Joellen M. , Pearce Celeste Leigh , Cramer Daniel W. , Rossing Mary Anne , Chenevix-Trench Georgia , Pharoah Paul D.P. , Gayther Simon A. , Ness Roberta B. , Odunsi Kunle , Sucheston Lara E. , Knutson Keith L. , Goode Ellen L.
Published: April 2023

PDF file - 157K, Supplemental Table 1. Regulatory T cell genes included in this study (N=25). Supplemental Table 2. Regulatory T cell SNPs included in this study. Supplemental Table 3. Participating invasive epithelial ovarian cancer studies. Supplemental Table 4. Association between clinical variables and overall survival.
Supplementary Table S2 from LncRNA-MM2P Identified as a Modulator of Macrophage M2 Polarization
Authors: Cao Ji , Dong Rong , Jiang Li , Gong Yanling , Yuan Meng , You Jieqiong , Meng Wen , Chen Zhanlei , Zhang Ning , Weng Qinjie , Zhu Hong , He Qiaojun , Ying Meidan , Yang Bo
Published: April 2023

table S2
Supplementary Table S1 from LncRNA-MM2P Identified as a Modulator of Macrophage M2 Polarization
Authors: Cao Ji , Dong Rong , Jiang Li , Gong Yanling , Yuan Meng , You Jieqiong , Meng Wen , Chen Zhanlei , Zhang Ning , Weng Qinjie , Zhu Hong , He Qiaojun , Ying Meidan , Yang Bo
Published: April 2023

Table S1
Supplementary Figure S4 from Enhancement of Peptide Vaccine Immunogenicity by Increasing Lymphatic Drainage and Boosting Serum Stability
Authors: Moynihan Kelly D. , Holden Rebecca L. , Mehta Naveen K. , Wang Chensu , Karver Mark R. , Dinter Jens , Liang Simon , Abraham Wuhbet , Melo Mariane B. , Zhang Angela Q. , Li Na , Gall Sylvie Le , Pentelute Bradley L. , Irvine Darrell J.
Published: April 2023

Supplementary Figure S4
Supplementary Figure 2 from Combining DNA Vaccine and AIDA-1 in Attenuated Salmonella Activates Tumor-Specific CD4+ and CD8+ T-cell Responses
Authors: Mei Yu , Zhao Lixiang , Liu Yonghao , Gong Huanle , Song Yuan , Lei Lei , Zhu Ying , Jin Ziqi , Ma Shoubao , Hu Bo , Sun Qing , Liu Haiyan
Published: April 2023

Representative flow cytometry plots for intracellular staining of TNF-alpha, IFN-gamma and IL-2 of CD4+ and CD8+ T cells from splenocytes on day 14 in lung metastasis model stimulated with B16-F10 lysates.
Table S2 from Allelic Polymorphisms of KIRs and HLAs Predict Favorable Responses to Tyrosine Kinase Inhibitors in CML
Authors: Ureshino Hiroshi , Shindo Takero , Kojima Hiroto , Kusunoki Yasushi , Miyazaki Yuki , Tanaka Hidenori , Saji Hiroh , Kawaguchi Atsushi , Kimura Shinya
Published: April 2023

Subgroups of KIR3DL1 and HLA-B
Supplementary Table 1 from Stromal Fibroblasts Mediate Anti–PD-1 Resistance via MMP-9 and Dictate TGFβ Inhibitor Sequencing in Melanoma
Authors: Zhao Fei , Evans Kathy , Xiao Christine , DeVito Nicholas , Theivanthiran Balamayooran , Holtzhausen Alisha , Siska Peter J. , Blobe Gerard C. , Hanks Brent A.
Published: April 2023

qRT-PCR primers used in the current study.
Supplementary Figure S5 from Stromal Fibroblasts Mediate Anti–PD-1 Resistance via MMP-9 and Dictate TGFβ Inhibitor Sequencing in Melanoma
Authors: Zhao Fei , Evans Kathy , Xiao Christine , DeVito Nicholas , Theivanthiran Balamayooran , Holtzhausen Alisha , Siska Peter J. , Blobe Gerard C. , Hanks Brent A.
Published: April 2023

Effect of melanoma-associated fibroblast MMP9 on immune responses to anti-PD1 therapy.
Supplementary Figures and Protein Gene Sequences from Converting Lymphoma Cells into Potent Antigen-Presenting Cells for Interferon-Induced Tumor Regression
Authors: Liao Jing , Luan Yan , Ren Zhenhua , Liu Xiaojuan , Xue Diyuan , Xu Hairong , Sun Zhichen , Yang Kaiting , Peng Hua , Fu Yang-Xin
Published: April 2023

Supplementary Figure 1. The depletion efficiency of normal B cell population by anti-CD20; Supplementary Figure 2. Anti-CD20-IFNα fusion protein demonstrated normal biological activities; Supplementary Figure 3. Intratumoral administration of type I IFN can effectively control B cell lymphoma; Supplementary Figure 4. BL3750 cells are sensitive and A20 cells are resistant to IFNα treatment; Supplementary Figure 5. CD8+ T cells are essential for i.v administrated anti-CD20-IFNα mediated tumor control; Supplementary Figure 6. CD4+ T cells are not essential for anti-CD20-IFNα mediated tumor control; Supplementary Figure 7. FTY720 induces a remarkable decrease of peripheral T cells; PGS-1. Anti-CD20 Gene Sequence; PGS-2. IFNα-hIgG1 Gene Sequence; PGS-3. Anti-CD20-IFNα Gene Sequence.
Supplementary Table S4 from Spliced Peptides and Cytokine-Driven Changes in the Immunopeptidome of Melanoma
Authors: Faridi Pouya , Woods Katherine , Ostrouska Simone , Deceneux Cyril , Aranha Ritchlynn , Duscharla Divya , Wong Stephen Q. , Chen Weisan , Ramarathinam Sri H. , Lim Kam Sian Terry C.C. , Croft Nathan P. , Li Chen , Ayala Rochelle , Cebon Jonathan S. , Purcell Anthony W. , Schittenhelm Ralf B. , Behren Andreas
Published: April 2023

Table S4
Supplementary Figure and Table Legends from Spliced Peptides and Cytokine-Driven Changes in the Immunopeptidome of Melanoma
Authors: Faridi Pouya , Woods Katherine , Ostrouska Simone , Deceneux Cyril , Aranha Ritchlynn , Duscharla Divya , Wong Stephen Q. , Chen Weisan , Ramarathinam Sri H. , Lim Kam Sian Terry C.C. , Croft Nathan P. , Li Chen , Ayala Rochelle , Cebon Jonathan S. , Purcell Anthony W. , Schittenhelm Ralf B. , Behren Andreas
Published: April 2023

Supplementary figure legends and tables descriptors
Supplementary Figures and Tables from LncRNA AK036396 Inhibits Maturation and Accelerates Immunosuppression of Polymorphonuclear Myeloid–Derived Suppressor Cells by Enhancing the Stability of Ficolin B
Authors: Tian Xinyu , Zheng Yu , Yin Kai , Ma Jie , Tian Jie , Zhang Yue , Mao Lingxiang , Xu Huaxi , Wang Shengjun
Published: April 2023

Supplementary figures 1-6 and supplementary tables 1 and 2
Supplementary Figures from The Gut Microbiome Is Associated with Clinical Response to Anti–PD-1/PD-L1 Immunotherapy in Gastrointestinal Cancer
Authors: Peng Zhi , Cheng Siyuan , Kou Yan , Wang Ziqi , Jin Rong , Hu Han , Zhang Xiaotian , Gong Ji-fang , Li Jian , Lu Ming , Wang Xicheng , Zhou Jun , Lu ZhiHao , Zhang Quan , Tzeng David T.W. , Bi Dongtao , Tan Yan , Shen Lin
Published: April 2023

Supplementary Figures
Supplementary Table legends from Dysregulated NF-κB–Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma
Authors: Maurer Deena M. , Adamik Juraj , Santos Patricia M. , Shi Jian , Shurin Michael R. , Kirkwood John M. , Storkus Walter J. , Butterfield Lisa H.
Published: April 2023

Supplementary Table legends 1-2
Supplementary Figures from Blockade of TIGIT/CD155 Signaling Reverses T-cell Exhaustion and Enhances Antitumor Capability in Head and Neck Squamous Cell Carcinoma
Authors: Wu Lei , Mao Liang , Liu Jian-Feng , Chen Lei , Yu Guang-Tao , Yang Lei-Lei , Wu Hao , Bu Lin-Lin , Kulkarni Ashok B. , Zhang Wen-Feng , Sun Zhi-Jun
Published: April 2023

Supplementary Figures
Figure S1 from Pathogen-Boosted Adoptive Cell Transfer Therapy Induces Endogenous Antitumor Immunity through Antigen Spreading
Authors: Xin Gang , Khatun Achia , Topchyan Paytsar , Zander Ryan , Volberding Peter J. , Chen Yao , Shen Jian , Fu Chunmei , Jiang Aimin , See William A. , Cui Weiguo
Published: April 2023

ReACT elicits an endogenous tumor-reactive CD8+ T cell response.
Supplementary Table from Poor Response to Neoadjuvant Chemotherapy Correlates with Mast Cell Infiltration in Inflammatory Breast Cancer
Authors: Reddy Sangeetha M. , Reuben Alexandre , Barua Souptik , Jiang Hong , Zhang Shaojun , Wang Linghua , Gopalakrishnan Vancheswaran , Hudgens Courtney W. , Tetzlaff Michael T. , Reuben James M. , Tsujikawa Takahiro , Coussens Lisa M. , Wani Khalida , He Yan , Villareal Lily , Wood Anita , Rao Arvind , Woodward Wendy A. , Ueno Naoto T. , Krishnamurthy Savitri , Wargo Jennifer A. , Mittendorf Elizabeth A.
Published: April 2023

Supplementary Table 1
Supplementary Figures from Poor Response to Neoadjuvant Chemotherapy Correlates with Mast Cell Infiltration in Inflammatory Breast Cancer
Authors: Reddy Sangeetha M. , Reuben Alexandre , Barua Souptik , Jiang Hong , Zhang Shaojun , Wang Linghua , Gopalakrishnan Vancheswaran , Hudgens Courtney W. , Tetzlaff Michael T. , Reuben James M. , Tsujikawa Takahiro , Coussens Lisa M. , Wani Khalida , He Yan , Villareal Lily , Wood Anita , Rao Arvind , Woodward Wendy A. , Ueno Naoto T. , Krishnamurthy Savitri , Wargo Jennifer A. , Mittendorf Elizabeth A.
Published: April 2023

Supplemental figures 1-11
Supplementary Table S4 from Direct Detection and Quantification of Neoantigens
Authors: Wang Qing , Douglass Jacqueline , Hwang Michael S. , Hsiue Emily Han-Chung , Mog Brian J. , Zhang Ming , Papadopoulos Nickolas , Kinzler Kenneth W. , Zhou Shibin , Vogelstein Bert
Published: April 2023

MAMA-SRM quantitative performance measured by tetramers.
Supplementary Table 1 from Head and Neck Cancers Promote an Inflammatory Transcriptome through Coactivation of Classic and Alternative NF-κB Pathways
Authors: Yang Xinping , Cheng Hui , Chen Jianhong , Wang Ru , Saleh Anthony , Si Han , Lee Steven , Guven-Maiorov Emine , Keskin Ozlem , Gursoy Attila , Nussinov Ruth , Fang Jugao , Van Waes Carter , Chen Zhong
Published: April 2023

61 gene list.
Supplementary Figure S1 from Direct Detection and Quantification of Neoantigens
Authors: Wang Qing , Douglass Jacqueline , Hwang Michael S. , Hsiue Emily Han-Chung , Mog Brian J. , Zhang Ming , Papadopoulos Nickolas , Kinzler Kenneth W. , Zhou Shibin , Vogelstein Bert
Published: April 2023

Structure of plasmid construct used for transfection.
Supplementary Data File from Bispecific Targeting of PD-1 and PD-L1 Enhances T-cell Activation and Antitumor Immunity
Authors: Kotanides Helen , Li Yiwen , Malabunga Maria , Carpenito Carmine , Eastman Scott W. , Shen Yang , Wang George , Inigo Ivan , Surguladze David , Pennello Anthony L. , Persaud Krishnadatt , Hindi Sagit , Topper Michael , Chen Xinlei , Zhang Yiwei , Bulaon Danielle K. , Bailey Tim , Lao Yanbin , Han Bing , Torgerson Stacy , Chin Darin , Sonyi Andreas , Haidar Jaafar N. , Novosiadly Ruslan D. , Moxham Christopher M. , Plowman Gregory D. , Ludwig Dale L. , Kalos Michael
Published: April 2023

Supplementary Figures 1-9 and Supplementary Tables 1-3
Original Western Blot Data from Targeting CMTM6 Suppresses Stem Cell–Like Properties and Enhances Antitumor Immunity in Head and Neck Squamous Cell Carcinoma
Authors: Chen Lei , Yang Qi-Chao , Li Yi-Cun , Yang Lei-Lei , Liu Jian-Feng , Li Hao , Xiao Yao , Bu Lin-Lin , Zhang Wen-Feng , Sun Zhi-Jun
Published: April 2023

Original Western Blot Data
Supplementary Tables from Transfer of MicroRNA via Macrophage-Derived Extracellular Vesicles Promotes Proneural-to-Mesenchymal Transition in Glioma Stem Cells
Authors: Zhang Zongpu , Xu Jianye , Chen Zihang , Wang Huizhi , Xue Hao , Yang Chunlei , Guo Qindong , Qi Yanhua , Guo Xiaofan , Qian Mingyu , Wang Shaobo , Qiu Wei , Gao Xiao , Zhao Rongrong , Guo Xing , Li Gang
Published: April 2023

Supplementary Tables 1-4
Figure S2 from Accumulation of Tumor-Infiltrating CD49a+ NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma
Authors: Sun Haoyu , Liu Lianxin , Huang Qiang , Liu Huan , Huang Mei , Wang Jiabei , Wen Hao , Lin Renyong , Qu Kun , Li Kun , Wei Haiming , Xiao Weihua , Sun Rui , Tian Zhigang , Sun Cheng
Published: April 2023

Global transcriptomic analysis on primary CD49a+ and CD49a- NK cells.
Figure S8 from Virus-Like Particle–Drug Conjugates Induce Protective, Long-lasting Adaptive Antitumor Immunity in the Absence of Specifically Targeted Tumor Antigens
Authors: Kines Rhonda C. , Thompson Cynthia D. , Spring Sean , Li Zhenyu , de los Pinos Elisabet , Monks Stephen , Schiller John T.
Published: April 2023

Gating examples for MHC Class I H-2Db-E749-57 tetramer staining (A) and intracellular cytokine staining after PBMC re-stimulation (B) shown in Figure 6. C) Unstained and Isotype controls for each data set.
Supplementary Data from CD28 Costimulatory Domain–Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function
Authors: Boucher Justin C. , Li Gongbo , Kotani Hiroshi , Cabral Maria L. , Morrissey Dylan , Lee Sae Bom , Spitler Kristen , Beatty Nolan J. , Cervantes Estelle V. , Shrestha Bishwas , Yu Bin , Kazi Aslamuzzaman , Wang Xuefeng , Sebti Said M. , Davila Marco L.
Published: April 2023

Supplemental Tables and Figures
Figure S8 from Tumor-Derived IL33 Promotes Tissue-Resident CD8+ T Cells and Is Required for Checkpoint Blockade Tumor Immunotherapy
Authors: Chen Lujun , Sun Runzi , Xu Junchi , Zhai Wensi , Zhang Dachuan , Yang Min , Yue Cuihua , Chen Yichao , Li Song , Turnquist Heth , Jiang Jingting , Lu Binfeng
Published: April 2023

PD-1 was highly expressed on tumor infiltrating CD4+ T or CD8+ T cells in B16 and B16-IL-33 tumors.
Figure S6 from Tumor-Derived IL33 Promotes Tissue-Resident CD8+ T Cells and Is Required for Checkpoint Blockade Tumor Immunotherapy
Authors: Chen Lujun , Sun Runzi , Xu Junchi , Zhai Wensi , Zhang Dachuan , Yang Min , Yue Cuihua , Chen Yichao , Li Song , Turnquist Heth , Jiang Jingting , Lu Binfeng
Published: April 2023

Dependence of CD8+ T cell function on ST2 and CD103.
Figure S5 from Tumor-Derived IL33 Promotes Tissue-Resident CD8+ T Cells and Is Required for Checkpoint Blockade Tumor Immunotherapy
Authors: Chen Lujun , Sun Runzi , Xu Junchi , Zhai Wensi , Zhang Dachuan , Yang Min , Yue Cuihua , Chen Yichao , Li Song , Turnquist Heth , Jiang Jingting , Lu Binfeng
Published: April 2023

Overexpression of secreted IL-33 in B16 tumors increased effector function of the tumor infiltrating T cells.
Supplementary Figures from Bispecific CAR T Cells against EpCAM and Inducible ICAM-1 Overcome Antigen Heterogeneity and Generate Superior Antitumor Responses
Authors: Yang Yanping , McCloskey Jaclyn E. , Yang Huan , Puc Janusz , Alcaina Yago , Vedvyas Yogindra , Gomez Gallegos Angel A. , Ortiz-Sánchez Elizabeth , de Stanchina Elisa , Min Irene M. , von Hofe Eric , Jin Moonsoo M.
Published: April 2023

Supplementary figure S1-S6
Supplementary Figures 1-7 and Supplementary Tables 1-2 from Self-Maintaining CD103+ Cancer-Specific T Cells Are Highly Energetic with Rapid Cytotoxic and Effector Responses
Authors: Abd Hamid Megat , Colin-York Huw , Khalid-Alham Nasullah , Browne Molly , Cerundolo Lucia , Chen Ji-Li , Yao Xuan , Rosendo-Machado Samara , Waugh Craig , Maldonado-Perez David , Bowes Emma , Verrill Clare , Cerundolo Vincenzo , Conlon Christopher P. , Fritzsche Marco , Peng Yanchun , Dong Tao
Published: April 2023

Supplementary Figures and Tables
Movie S2 from Self-Maintaining CD103+ Cancer-Specific T Cells Are Highly Energetic with Rapid Cytotoxic and Effector Responses
Authors: Abd Hamid Megat , Colin-York Huw , Khalid-Alham Nasullah , Browne Molly , Cerundolo Lucia , Chen Ji-Li , Yao Xuan , Rosendo-Machado Samara , Waugh Craig , Maldonado-Perez David , Bowes Emma , Verrill Clare , Cerundolo Vincenzo , Conlon Christopher P. , Fritzsche Marco , Peng Yanchun , Dong Tao
Published: April 2023

Movie S2 shows CD103+ T cell killing HCT116 cancer cell, by calcium flux imaging.
Supplementary Tables and Figures: Table S1, Table S2, Table S3, Table S4, Table S5, Table S6, Figure S1, Figure S2, Figure S3, Figure S4, Figure S5, Figure S6 from Tumor Cell–Derived TGFβ1 Attenuates Antitumor Immune Activity of T Cells via Regulation of PD-1 mRNA
Authors: Wu Pengfei , Geng Bo , Chen Qun , Zhao Enyang , Liu Jiang , Sun Chen , Zha Caijun , Shao Yong , You Bosen , Zhang Wenfu , Li Lulu , Meng Xiangqi , Cai Jinquan , Li Xuedong
Published: April 2023

Supplementary Tables and Figures: Table S1, Table S2, Table S3, Table S4, Table S5, Table S6, Figure S1, Figure S2, Figure S3, Figure S4, Figure S5, Figure S6
Figure S1-S4 from Host IL11 Signaling Suppresses CD4+ T cell–Mediated Antitumor Responses to Colon Cancer in Mice
Authors: Huynh Jennifer , Baloyan David , Chisanga David , Shi Wei , O'Brien Megan , Afshar-Sterle Shoukat , Alorro Mariah , Pang Lokman , Williams David S. , Parslow Adam C. , Thilakasiri Pathum , Eissmann Moritz F. , Boon Louis , Masson Frederick , Chand Ashwini L. , Ernst Matthias
Published: April 2023

Supplementary Figure 1. Gating strategy and representative flow cytometric plots of MC38 tumors from WT and Il11ra-/- hosts. Supplementary Figure 2. IL-11 has no effect on tumor-infiltrating immune cells in MC38 and CT26 tumors from WT and Il11ra-/- hosts. Supplementary Figure 3. IL-11 has no effect on PMA/Iono-induced IFNγ and TNFα production by IL-11RA-deficient CD4+ T cells. Supplementary Figure 4. Single cell profiling of IL11RA and IFNG expression in intra-tumoral CD4+ T cells from colon cancer patients.
Supplementary Figures from IL1α Antagonizes IL1β and Promotes Adaptive Immune Rejection of Malignant Tumors
Authors: Tian Tian , Lofftus Serena , Pan Youdong , Stingley Claire A. , King Sandra L. , Zhao Jingxia , Pan Timothy Y. , Lock Rebecca , Marglous Jacob W. , Liu Kevin , Widlund Hans R. , Fuhlbrigge Robert C. , Cichowski Karen , Kupper Thomas S.
Published: April 2023

Supplementary Figures S1-S4
Supplementary Data from Personalized Single-Cell Proteogenomics to Distinguish Acute Myeloid Leukemia from Nonmalignant Clonal Hematopoiesis
Authors: Dillon Laura W. , Ghannam Jack , Nosiri Chidera , Gui Gege , Goswami Meghali , Calvo Katherine R. , Lindblad Katherine E. , Oetjen Karolyn A. , Wilkerson Matthew D. , Soltis Anthony R. , Sukumar Gauthaman , Dalgard Clifton L. , Thompson Julie , Valdez Janet , DeStefano Christin B. , Lai Catherine , Sciambi Adam , Durruthy-Durruthy Robert , Llanso Aaron , Gulati Saurabh , Wang Shu , Ooi Aik , Dagur Pradeep K. , McCoy J. Philip , Burr Patrick , Li Yuesheng , Hourigan Christopher S.
Published: April 2023

Supplementary Data
Supplementary Tables 1-2 from Tumor Purity in Preclinical Mouse Tumor Models
Authors: Qian Wubin , Chen Xiaobo , Sheng Yanghui , Zhang Likun , Wang Jingjing , Song Zhenzhen , Li Qi-Xiang , Guo Sheng
Published: April 2023

Table S1-S2
Supplementary Figure 6 from Tumor Purity in Preclinical Mouse Tumor Models
Authors: Qian Wubin , Chen Xiaobo , Sheng Yanghui , Zhang Likun , Wang Jingjing , Song Zhenzhen , Li Qi-Xiang , Guo Sheng
Published: April 2023

PDX tumor purity change by passage for 8 cancers.
Surgical Considerations in Addressing Cholesterol Granuloma of the Petrous Apex through an Infracochlear Approach
Authors: Košec Andro , Prnjak Josip , Tomljenović Robert , Ries Mihael
Published: April 2023

Cholesterol granuloma of the petrous bone is a foreign body giant cell reaction to cholesterol deposits with symptoms including hearing loss, vestibular dysfunction, and cranial nerve deficit as a result of cystic mass compression. Surgical treatment is often difficult to plan due to limited access to the lesion and possible injury to surrounding structures. We report on a case of petrous apex cholesterol granuloma drainage through an infracochlear approach. A 27-year-old female patient presented with acute diplopia due to left-sided abducens paralysis. Multislice computed tomography (MSCT) and magnetic resonance (MR) imaging described a 3.5-cm well-marginated lesion in petrous bone apex, compressing the left abducens nerve at the point of entry into the cavernous sinus, corresponding to cholesterol granuloma. The patients was surgically treated through a transcanal infracochlear approach, since preserving the external and middle ear conduction mechanisms was paramount for the patient. The patient was discharged on the second postoperative day and diplopia resolved within 5 days postoperatively. Six months after the surgery, her hearing on the left side is normal, and she remains symptom-free. This case underpins the value of preoperative planning when approaching the petrous apex, an anatomically complex area due to abundance of important neurovascular structures crowded in a narrow and confined region.
Sweet Syndrome: A Review of Published Cases
Authors: Orfaly Victoria Edlyne , Shakshouk Hadir , Heath Micheal , Hamilton Andrew , Ortega-Loayza Alex G
Published: April 2023

Sweet syndrome (SS), the prototypical neutrophilic dermatosis, is characterized by abrupt onset of tender plaques and nodules, classically accompanied by fever and leukocytosis. While management mainly relies on systemic corticosteroids, inadequate response can be seen in some patients that necessitates exploring other treatment options. Early diagnosis of malignancy-associated SS (MA-SS) along with detection of concomitant malignancy is crucial for improving patients’ outcomes. Data regarding various clinical manifestations, extracutaneous associations, treatment, and outcomes are poorly characterized in the literature. We aimed to review all published case reports and case series to portray clinical features of SS including extracutaneous manifestations. We also describe reported treatment options and their outcomes to draw attention toward unmet therapeutic needs in the management of SS. In addition, for clinical and practical purposes, we attempted to delineate the distinction between MA-SS and nonmalignant subtypes of SS.
Optical Properties of Sodium-doped Carbon Dots Made of Urea and Trisodium Citrate
Authors: Isnaeni Isnaeni , Purwandari Vivi , Putro Permono Adi , Adiwidya Hammam Magma
Published: April 2023

Carbon dots are very interesting carbon-based nanoparticles. Carbon dots have unique optical properties, especially luminescence properties upon light excitation. Improving optical quality is the challenge in carbon dots research. Doping is one of the methods to improve the quality of carbon dots. In this work, we used sodium, which is an active ion, as doping in the carbon dots. We studied the optical properties of sodium-doped carbon dots. We found that absorbance, FTIR, and photoluminescence spectra changed due additional surface energy level of carbon dots. Furthermore, the quantum yield of carbon dots improved significantly due to sodium doping. In addition, the phosphorescence of sodium-doped carbon dots was slightly longer. Electron behavior was also changed. In conclusion, sodium-doped carbon dots showed very good optical properties for further applications.
FHL5 Controls Vascular Disease–Associated Gene Programs in Smooth Muscle Cells
Authors: Wong Doris , Auguste Gaëlle , Lino Cardenas Christian L. , Turner Adam W. , Chen Yixuan , Song Yipei , Ma Lijiang , Perry R. Noah , Aherrahrou Redouane , Kuppusamy Maniselvan , Yang Chaojie , Mosquera Jose Verdezoto , Dube Collin J. , Khan Mohammad Daud , Palmore Meredith , Kalra Jaspreet , Kavousi Maryam , Peyser Patricia A. , Matic Ljubica , Hedin Ulf , Manichaikul Ani , Sonkusare Swapnil K. , Civelek Mete , Kovacic Jason C. , Björkegren Johan L.M. , Malhotra Rajeev , Miller Clint L.
Published: April 2023

Background:

Genome-wide association studies have identified hundreds of loci associated with common vascular diseases, such as coronary artery disease, myocardial infarction, and hypertension. However, the lack of mechanistic insights for many GWAS loci limits their translation into the clinic. Among these loci with unknown functions is
UFL1
–four-and-a-half LIM (LIN-11, Isl-1, MEC-3) domain 5 (
FHL5
; chr6q16.1), which reached genome-wide significance in a recent coronary artery disease/ myocardial infarction GWAS meta-analysis.
UFL1-FHL5
is also associated with several vascular diseases, consistent with the widespread pleiotropy observed for GWAS loci.

Methods:

We apply a multimodal approach leveraging statistical fine-mapping, epigenomic profiling, and ex vivo analysis of human coronary artery tissues to implicate
FHL5
as the top candidate causal gene. We unravel the molecular mechanisms of the cross-phenotype genetic associations through in vitro functional analyses and epigenomic profiling experiments in coronary artery smooth muscle cells.

Results:

We prioritized
FHL5
as the top candidate causal gene at the
UFL1-FHL5
locus through expression quantitative trait locus colocalization methods.
FHL5
gene expression was enriched in the smooth muscle cells and pericyte population in human artery tissues with coexpression network analyses supporting a functional role in regulating smooth muscle cell contraction. Unexpectedly, under procalcifying conditions, FHL5 overexpression promoted vascular calcification and dysregulated processes related to extracellular matrix organization and calcium handling. Lastly, by mapping FHL5 binding sites and inferring FHL5 target gene function using artery tissue gene regulatory network analyses, we highlight regulatory interactions between FHL5 and downstream coronary artery disease/myocardial infarction loci, such as
FOXL1
and
FN1
that have roles in vascular remodeling.

Conclusions:

Taken together, these studies provide mechanistic insights into the pleiotropic genetic associations of
UFL1-FHL5.
We show that FHL5 mediates vascular disease risk through transcriptional regulation of downstream vascular remodeling gene programs. These transacting mechanisms may explain a portion of the heritable risk for complex vascular diseases.
Racial Differences in Student Access to High-Quality Teachers
Authors: Clotfelter Charles T. , Ladd Helen F. , Clifton Calen R.
Published: April 2023

Access to high-quality teachers in K–12 schools differs systematically by racial group. This policy brief reviews the academic research documenting these differences and the labor market forces and segregation patterns that solidify them. It also presents new analysis of differential exposure in North Carolina of white, black, and Hispanic students to teachers with different quality-related credentials across five grade–subject combinations. White students are most often in classrooms taught by teachers with strong credentials and least often by those with weak credentials, not only across the state as a whole, but also within most of the state's counties, especially those whose schools are most segregated by race. To address such disparities, decision makers at all three levels—state, district, and school—have various policy options to consider, with each level having an important role to play.
Introduced Mediterranean painted frogs (Discoglossus pictus) are possible supershedders of the fungus Batrachochytrium dendrobatidis in Catalonia (NE Spain)
Authors: Martínez-Silvestre Albert , Loras-Ortí Fernando , Garcia-Salmeron Alejandro , Pujol-Buxó Eudald , Pérez-Novo Iago , Maluquer-Margalef Joan , Poch Santiago , Thumsová Barbora , Bosch Jaime
Published: April 2023

In 2020 and 2021 we detected in Catalonia (NE Spain) six new episodes of mortality or presence of dying specimens in introduced Mediterranean painted frogs (Discoglossus pictus). All affected individuals were positive to the amphibian chytrid fungus Batrachochytrium dendrobatidis (Bd). Histological examinations showed intense involvement of the superficial layers of the epidermis and qPCR analyses yielded infection loads greater than 100 000 genomic equivalents of zoospores. These results suggest that this introduced species could behave as a Bd ‘supershedder’, and recommend to control its expansion due to its important role in the dynamic of chytridiomycosis.
Effects of P70 S6 kinase on the ageing process and reproduction of Daphnia pulex (Branchiopoda, Anomopoda)
Authors: Zhao Chun-Pu , Lin Chong-Yuan , Zhang Shun , Wang Ya-Jun , Xu Shan-Liang , Wang Dan-Li , Guo Chun-Yang
Published: April 2023

Daphnia pulex is a natural food widely used in aquaculture, and S6K plays an important role in protein translation and ageing. To explore the function of S6K in the ageing process of D. pulex, we cloned and analysed the full-length cDNA of S6K. With the growth of D. pulex, the expression of S6K mRNA first increased, then peaked at 10 days, and then decreased. Western blot analysis showed that the S6K protein expression increased from 1 to 5 days of age, but did not change significantly from 5 to 25 days of age. RNAi knockdown of S6K, reduced the expression of S6K mRNA and S6K protein, and it causes changes in other genes associated with ageing in both sexes. S6K may be involved in reproductive transformation, affecting reproductive capacity, thus significantly affecting the ageing of D. pulex. miRNA with potential regulation of the S6K gene were screened by the bioinformatics method and validated using a dual luciferase reporter gene system. This study deepens our understanding of the mechanisms of ageing in D. pulex and expands our understanding of the role of S6K in the ageing process.
Richard Kearney’s Sacramental Play between Immanence and Transcendence
Authors: Damen Enrieke
Published: April 2023

This article will discuss anatheist imagination in Kearney’s work. With the help of a poem by Sharon Olds, it will make a case for the sacramental – or anatheist – play between immanence and transcendence as a crucial motif to interpreting Kearney’s philosophy. Firstly, illustrating that the sacramental opens the door to a more embodied and carnal understanding of Kearney’s hermeneutics. Secondly, drawing on insights from my research, I’ll argue in a short history of anatheist imagination that there’s a continuity between the sacramental and Kearney’s early work on the hermeneutics of the possible. Finally, the article concludes with some considerations on the philosophical and/or theological character of Kearney’s emphasis on the sacramental imagination as a hermeneutic stance.
The genus Onchodellus Berlese in Türkiye (Mesostigmata: Pachylaelapidae), with a new record and three new species
Authors: ÖZBEK HASAN HÜSEYIN
Published: April 2023

This study reports on a collection of mites of the genus Onchodellus from different cities in Türkiye (Adana, Gümüşhane, Giresun, Tokat). Four species were identified in the genus—Onchodellus acrophilus sp. nov. O. circularis sp. nov. and O. kosensis sp. nov. are described as new, and O. karawaiewi (Berlese, 1920) is a new record from Türkiye.
The Onset of a Blocking Event as a “Traffic Jam”: Characterization with Ensemble Sensitivity Analysis
Authors: Polster Christopher , Wirth Volkmar
Published: April 2023

Recently, Nakamura and Huang proposed a theory of blocking onset based on the budget of finite-amplitude local wave activity on the midlatitude waveguide. Blocks form in their idealized model due to a mechanism that also describes the emergence of traffic jams in traffic theory. The current work investigates the development of a winter European block in terms of finite-amplitude local wave activity to evaluate the possible relevance of the “traffic jam” mechanism for the flow transition. Two hundred members of a medium-range ensemble forecast of the blocking onset period are analyzed with correlation- and cluster-based sensitivity techniques. Diagnostic evidence points to a traffic jam onset on 17 December 2016. Block development is sensitive to upstream Rossby wave activity up to 1.5 days prior to its initiation and consistent with expectations from the idealized theory. Eastward transport of finite-amplitude local wave activity in the southern part of the block is suppressed by nonlinear flux modification from the large-amplitude blocking pattern, consistent with the expected obstruction in the traffic jam model. The relationship of finite-amplitude local wave activity and its zonal flux as mapped by the ensemble exhibits established characteristics of a traffic jam. This study suggests that the traffic jam mechanism may play an important role in some cases of blocking onset and more generally that applying finite-amplitude local wave activity diagnostics to ensemble data is a promising approach for the further examination of individual onset events in light of the Nakamura and Huang theory.

Significance Statement

Blocking is an occasional phenomenon in the mid- and high-latitude atmosphere characterized by the stalling of weather systems. Episodes of blocking are linked to extreme weather but their occurrence is not completely understood. A recent theory suggests that blocks may form in the jet stream like traffic jams on a highway. The onset mechanism contained in the theory could explain why forecasts of blocking are sometimes poor. In this work, we investigate the formation of a 2016 European winter block in the context of the traffic jam theory. Though questions remain regarding the implications for forecast uncertainty, our findings strongly support the notion of a traffic jam onset.
Atmospheric Drivers of Tasman Sea Marine Heatwaves
Authors: Gregory Catherine H. , Holbrook Neil J. , Marshall Andrew G. , Spillman Claire M.
Published: April 2023

Marine heatwaves (MHWs) can severely impact marine biodiversity, fisheries, and aquaculture. Consequently, there is an increasing desire to understand the drivers of these events to inform their predictability so that proactive decisions may be made to reduce potential impacts. In the Tasman Sea (TS), several relatively intense and broad-scale MHWs have caused significant damage to marine fisheries and aquaculture industries. To assess the potential predictability of these events, we first determined the main driver of each MHW event in the TS from 1993 to 2021. We found that those MHWs driven by ocean advection—approximately 45% of all events—are generally longer in duration and less intense and affected a smaller area compared with the remaining 55%, which are driven by air–sea heat fluxes, are shorter in duration, and are more surface intense. As ocean advection–driven events in the TS have been closely studied and reported previously, we focus here on atmospherically driven MHWs. The predictability of these events is assessed by identifying the patterns of atmospheric pressure, winds, and air–sea heat fluxes in the Southern Hemisphere that coincide with MHWs in the Tasman Sea. We found that atmospherically driven MHWs in this region are more likely to occur during the positive phase of the asymmetric Southern Annular Mode (A-SAM)—which presents as an atmospheric zonal wave-3 pattern and is more likely to occur during La Niña years. These A-SAM events are linked to low wind speeds and increased downward solar radiation in the TS, which lead to increased surface ocean temperatures through the reduction of mixing.

Significance Statement

The purpose of this study is to understand factors of the atmosphere that contribute to an accumulation of heat in the upper ocean in the Tasman Sea to better inform predictability. Higher incidences of ocean extreme thermal events (known as marine heatwaves) in this region are becoming increasingly more common and threatening the important marine industries that support the people of both Australia and New Zealand. We need to know the sources of this extra heat to understand whether such events can be predicted. Previous studies have found the East Australian Current to be responsible for around half of these events, and our results show a connection between a known atmospheric pattern and the other half. As we continue to improve our ability to anticipate this pattern, this suggests that we may also be able to predict these extreme heating events.
Trends in Northern Hemispheric Snow Presence
Authors: Jia Yisu , Lund Robert , Kong Jiajie , Dyer Jamie , Woody Jonathan , Marron J. S.
Published: April 2023

This paper develops a mathematical model and statistical methods to quantify trends in presence/absence observations of snow cover (not depths) and applies these in an analysis of Northern Hemispheric observations extracted from satellite flyovers during 1967–2021. A two-state Markov chain model with periodic dynamics is introduced to analyze changes in the data in a cell by cell fashion. Trends, converted to the number of weeks of snow cover lost/gained per century, are estimated for each study cell. Uncertainty margins for these trends are developed from the model and used to assess the significance of the trend estimates. Cells with questionable data quality are explicitly identified. Among trustworthy cells, snow presence is seen to be declining in almost twice as many cells as it is advancing. While Arctic and southern latitude snow presence is found to be rapidly receding, other locations, such as eastern Canada, are experiencing advancing snow cover.

Significance Statement

This project quantifies how the Northern Hemisphere’s snow cover has recently changed. Snow cover plays a critical role in the global energy balance due to its high albedo and insulating characteristics and is therefore a prominent indicator of climate change. On a regional scale, the spatial consistency of snow cover influences surface temperatures via variations in absorbed solar radiation, while continental-scale snow cover acts to maintain thermal stability in the Arctic and subarctic regions, leading to spatial and temporal impacts on global circulation patterns. Changing snow presence in Arctic regions could influence large-scale releases of carbon and methane gas. Given the importance of snow cover, understanding its trends enhances our understanding of climate change.
Lacan and Culturalism: A Chronicle of an “Untimely” Resistance to Psychoanalysis
Authors: Guérin Nicolas
Published: April 2023

Although neither Sigmund Freud nor Jacques Lacan ever neglected the place of culture and the social field for the subject, they always opposed “culturalist” ideas, even when such ideas no longer used this label. It is important to examine what both of these figures said about culturalism, but it is just as pertinent to return to other criticisms of this movement, which developed in the United States during the last century, because at present this movement has returned covertly within French psychoanalysis. First, “culturalism” is neither a specifically American problem nor one that belongs to the past. Second, some decisive criticisms of this movement remain both germane and original: they are able to throw light on a theoretical current that, at least in France, now characterizes a dominant orientation of psychoanalytic work. Third, although Lacan himself foresaw it, the misuse of some of his notions has unexpectedly served as a Trojan horse that has enabled culturalism to return.
A Psychoanalytic Institute’s Response to Existential threats: A Case Study of Organizational Self-Inquiry and External Consultation
Authors: Barron James W. , Honig Richard G. , Lebovitz Phil S.
Published: April 2023

The term institute is used inclusively here to refer to different organizational structures such as psychoanalytic societies and centers. Those organizations have primary tasks such as providing education and training in psychoanalysis and psychoanalytic psychotherapy. Existential threats covers a range of factors, both internal and external to an organization, that may seriously impair or destroy its capacity to carry out its primary tasks and to survive as a functioning entity. Perceptions and responses relating to those threats are dynamic processes within the organization that shift and evolve over time. This case study explores one institute’s use of organizational self-inquiry and external consultation to strengthen its capacity to perceive, make meaning of, and respond adaptively to those threats. The qualitative research for this case study is based on a series of semistructured individual interviews with a representative sample of participants in the consultation, close attention to the intersubjective experiences of interviewees and interviewers, and careful thematic analysis of the interview data. Interviewees shared their understanding of what led up to the consultation, their experience of the consultation, and their perception of its immediate and ongoing impact. Many interviewees felt that the consultation helped strengthen the institute’s organizational capacity for resilience and innovation, expressed the desire for additional consultation to ensure the institute’s survival and ongoing health, recommended that the institute include the study of organizational dynamics in its curriculum, and thought it should develop its internal capacity for organizational self-inquiry.
Empirically Derived Single-Case-Design Effect Size Distributions of Engagement and Challenging Behavior in Early Childhood Research
Authors: Chow Jason C. , Ledford Jennifer R. , Windsor Sienna , Bennett Paige
Published: April 2023

The purpose of this study is to present a set of empirically derived effect size distributions in order to provide field-based benchmarks for assessing the relative effects of interventions aimed at reducing challenging behavior or increasing engagement for young children with and without disabilities. We synthesized 192 single-case designs that represented data from 162 individuals and nine groups of individuals (e.g., classes) in 53 reports. We generated distributions of standardized mean difference and log-response ratio using 197 effect sizes for engagement and 146 effect sizes for challenging behavior. We examined benchmarks as a function of publication, disability, dependent variable (primary/secondary), and functional relation status and reported distributions separately by engagement and challenging behavior. Overall, the effect size distributions suggest considerable variability in the magnitude of change associated with school-based interventions for engagement and challenging behavior assessed in the context of single-case designs. Data suggest that expected magnitude of change for engagement and challenging behavior interventions may be difficult to predict and that study and effect size characteristics influence the variability of the distributions. Our results have direct implications for researchers relative to assessing the efficacy of interventions aimed at reducing challenging behavior or increasing engagement in young children with and without disabilities.
Postponement and Transfer of Death in Traditional Igbo Society: The Case of Ngwere Ishi Enwoo Among Nsukka People: A Historico-Philosophical Analysis
Authors: Opata Christian Chukwuma , Ufearoh Anthony Uzochukwu , Eze Hillary Oguejiofor
Published: April 2023

Traditional medical practice among the Igbo is not limited to therapeutic or curative role of healing the sick. It extends to exploration and manipulation of powers inherent in nature and material entities to achieve some ends. This is popularly known as ime ọgwụ ( igwọ ọgwọ) in Igbo parlance. One of such manipulative function is the phenomenon of postponement or transfer of death from a patient to another individual without any direct or physical contact. The process raises serious philosophical concerns about causation as well as the ethical justification of the act. Employing simultaneously the empirical method, the philosophical methods of phenomenological analysis and hermeneutics, the present paper sets out to investigate the possibility of relating the cause with the effect in the phenomenon of postponement and porting of death from an individual to another. The paper explores the Igbo-African ontological understanding of realities as forces and mutual interaction of forces.
Contribution of zeolite to remove malachite green in aqueous solution by adsorption processes: Kinetics, isotherms and thermodynamic studies
Authors: Abbas Moussa , Trari Mohamed
Published: April 2023

The textile industry produces huge amounts of wastewaters containing synthetic dyes. In the textile industry, acid, basic, reactive, dispersed chemicals are widely used for dyeing. The aim of this study was to evaluate the adsorption of malachite green onto zeolite from aqueous solutions was realized in batch system. The adsorbent was characterized by the Fourier transform infrared spectroscopy, X-ray analysis, and zero point charge (pHzpc = 10.42). However, some examined factors were found to have significant impacts on the adsorption capacity of zeolite such as the initial malachite green concentration (Co), solution pH, adsorbent dose, agitation speed, particles size, and temperature. The best capacity was found at pH 8 with an adsorbent dose 0.2 g/l, an agitation speed 200 rpm and a contact time of 40 min. The kinetic adsorptions were found to follow rather a pseudo-second order kinetic model with a determination coefficient (R2) of 0.999. The equilibrium adsorption data for the malachite green adsorption onto the zeolite were analyzed by the Langmuir, Freundlich, Elovich, and Temkin models. The results indicate that the Langmuir model provides the best correlation with a capacity qmax of 83.33 mg/g at 25°C. The adsorption isotherms at different temperatures have been used for the determination of thermodynamic parameters, namely the free energy (ΔG°); enthalpy (ΔH°) and entropy (ΔS°) to predict the nature of adsorption. The positive values of ΔG° and ΔH° indicate that the overall adsorption is not spontaneous and endothermic with a physisorption process. The adsorbent elaborated from the zeolite was found to be efficient and suitable for the elimination of reactive dyes from aqueous solutions, due to its availability of adsorption sites, low cost preparation, and good uptake capacity.
Metanephric adenoma an unusual renal mass: A rare case
Authors: Anshu Alok , Kumar Anil
Published: April 2023

Metanephric adenoma is a rare benign mass that may be radiologically indistinguishable from renal cell carcinoma. The clinical presentation of this entity is similar to a malignant renal mass. Only 200 cases have been reported worldwide till now. Furthermore, there are no strongly predictive clinical and radiological criteria. It, therefore, poses a diagnostic challenge. Since post-operative therapy may vary significantly if the lesion turns out to be malignant, it is crucial to distinguish it from other malignant renal masses.