bluuebunny/crossref_metadata_2025 huggingface dataset:
Low vaccination and infection rate of Omicron in patients with inflammatory bowel disease: a comparative study of three unique cohorts
Authors: Feng Jing , Yang Tian , Yao Ruchen , Feng Bo , Hao Renshan , Qiao Yuqi , Tong Jinlu , Shen Jun
Published: June 2023

Background

The SARS-CoV-2 Omicron variant caused a large-scale outbreak of COVID-19 in Shanghai, China. Patients with inflammatory bowel disease (IBD) are at high risk of infection due to immunosuppressive interventions. We aimed to investigate the vaccination information of patients with IBD and update a vaccination guide based on a comparison of vaccination in asymptomatic carriers and healthy individuals.

Methods

This retrospective study was conducted during an Omicron variant wave. We assessed the vaccination status in patients with IBD, asymptomatic carriers and healthy individuals. Factors with unvaccinated status and adverse events following vaccination were also determined in patients with IBD.

Results

The vaccination rate was 51.2% in patients with IBD, 73.2% in asymptomatic carriers, and 96.1% in healthy individuals. Female sex (p = 0.012), Crohn’s disease (p = 0.026), and disease behavior of B3 (p = 0.029) were factors that indicated a lower vaccination rate. A significantly higher proportion of healthy individuals had received one booster dose (76.8%) than asymptomatic carriers (43.4%) and patients with IBD (26.2%). Patients with IBD received vaccination without an increased risk of adverse events (p = 0.768).

Conclusion

The vaccination rate of patients with IBD remains much lower than that of asymptomatic carriers and healthy individuals. The COVID-19 vaccine has been found to be safe among all three groups and patients with IBD are not more susceptible to adverse events.
Fear of COVID-19, risk perception and preventive behavior in health workers: a cross-sectional analysis in middle-income Latin American countries
Authors: Bonilla-Asalde César Antonio , Rivera-Lozada Oriana , Ipanaqué-Zapata Miguel , Castro-Alzate Elvis Siprian , Pacheco-Lopez Robinson , Rivera-lozada Isabel Cristina , Chong Félix , Sagastume Lucrecia Ramírez
Published: June 2023

The aim of this study was to examine the association between fear of COVID-19 and risk perception with preventive behavior in health professionals from four Latin American countries. An analytical cross-sectional study was conducted. Health professionals with on-site care in Colombia, Ecuador, Guatemala, and Peru were surveyed. Information was collected through an online self-report questionnaire. The main variables were preventive behavior as the dependent variable and fear of COVID-19 and risk perception as independent variables. Linear regression was used, and unstandardized beta coefficient and value of ps were calculated. Four hundred and thirty-five health professionals were included, the majority were aged 42 years or older (45.29, 95%CI: 40.65–50.01) and female (67.82, 95%CI: 63.27–72.05). It was shown that the greater the fear of COVID-19, the greater the preventive behavior of COVID-19 infection (B = 2.21, p = 0.002 for total behavior; B = 1.12, p = 0.037 for additional protection at work; B = 1.11, p < 0.010 for hand washing). The risk perception of COVID-19 infection had a slight direct relationship with preventive behaviours (B = 0.28, p = 0.021 for total behavior; B = 0.13, p = 0.015 for hand washing), with the exception of the preventive behavior of using additional protection at work (p = 0.339). We found that fear and risk perception are associated with increased practice of hand washing and use of additional protection at work. Further studies are required on the influence of working conditions, job performance and the occurrence of mental health problems in frontline personnel with regard to COVID-19.
Prevalence of and risk factors for chlamydia in female outpatients with genital tract infections: a nationwide multi-center, cross-sectional study in China
Authors: Li Ting , Liu Zhaohui , Zhang Dai , Liao Qinping , Fan Shangrong , Hao Min , Hong Ying , Huang Xiufeng , Wang Huilan , Xiong Zhengai , Xu Hong , Xue Fengxia , Xue Min , Yang Xingsheng , Zhang Jianqing
Published: June 2023

Introduction

Chlamydia trachomatis is the etiological agent of the commonest sexually transmitted bacterial infection. This study aimed to examine the prevalence of genital chlamydia and associated risk factors in Chinese female outpatients with genital tract infections.

Methods

A prospective, multicenter epidemiological study of genital chlamydia prevalence in 3008 patients with genital tract infections in 13 hospitals in 12 provinces of China was performed between May 2017 and November 2018. Vaginal secretion specimens were collected for the clinical diagnosis of vaginitis, whereas cervical secretion specimens were tested for Chlamydia trachomatis and Neisseria gonorrhoeae. All patients participated in a one-on-one cross-sectional questionnaire interview.

Results

Totally 2,908 participants were included. The prevalence rates of chlamydia and gonococcal infections in women with genital tract infections were 6.33% (184/2908) and 0.01% (20/2908), respectively. Multivariate analysis showed high risk factors for chlamydia were premarital sex behavior, first sexual intercourse before the age of 20 and bacterial vaginosis.

Discussion

Given that most chlamydia cases are asymptomatic and no vaccine is currently available, chlamydia prevention strategies should include behavioral interventions as well as early screening programs to identify and treat individuals with genital tract infections, especially those with the above identified risk factors.
Online short videos promoting public breast cancer literacy: a pretest-posttest control group trial on efficiency, attitude, and influencing factors
Authors: Xu Qian-Rui , Wu Pei-Zhu , Du Jia-Zi , Zhuang Wen-Jun , He Xiao-Tong , Ma Yong-Yong , Zeng De , Liang Yuan-Ke , Xu Xiao-Yang , Xie Lei , Lin Hao-Yu
Published: June 2023

Background

Short videos on social media are playing an increasingly important role in cancer health education today. It is important to explore how the actual communication effect of health videos and the knowledge absorption of users are influenced by different factors of the video creation process.

Objective

The objective of our study is to access the factors influencing breast cancer health education through short videos on efficiency and quality.

Methods

Three pairs of videos about breast health were created and participants completed questionnaires before and after watching the videos. A paired t-test was used to analyze within-group change scores. RM-ANOVA was used to assess the relationship between the pretest, posttest, and three variables.

Results

Watching short videos can significantly increase viewers’ knowledge of related health topics (p < 0.05). The viewers’ concentration level while watching was significantly higher for the video with background music (BGM) than for the video without BGM (p = 0.006). The viewers’ willingness to share was significantly higher for the video with a progress bar than for the video without a progress bar (p = 0.02). Using an interpreter wearing a doctor’s uniform instead of casual wear and setting a progress bar can significantly improve the efficiency of knowledge absorption (p < 0.05).

Conclusion

A uniformed interpreter, BGM and a progress bar are factors influencing the efficiency of short health videos. They can be applied in video making to explore better ways of promoting cancer health education in the new mobile Internet environment.
Socio-economic impacts of climate change on indigenous communities in the save valley area of Chipinge district, Zimbabwe
Authors: Sithole Portia Kimberley , Mawere Munyaradzi , Mubaya Tapuwa Raymond
Published: June 2023

In recent years, climate change has fast become a reality that warrants concerted action from stakeholders across fields. Communities in the Save Valley Area of Chipinge District of Manicaland Province in Zimbabwe, for example, report high incidences of socio-economic disruptions caused by climate change. These include loss of livelihoods, livestock, crops, food stocks and infrastructure damage. This study investigated the coping mechanisms adopted by communities in the Save Valley Area in their attempt to mitigate the socio-economic vagaries of climate change. In order to understand community perceptions regarding the possible link between climate change and the increased frequency and intensity of flooding incidences and to evaluate the evolution of community disaster risk management and resilience building as a function of changing climatic realities, the study employed the mixed method research design. Resettled farming households in the Middle Sabi, communal farming households in Chibuwe and Tongogara areas and members of the Chipinge District Development Committee were sampled for this study. Questionnaires, transact walks, structured interviews and focus group discussions were the main data collection methods utilized. Quantitative data entry was done via the Statistical Package for Social Sciences (SPSS) software. Qualitative data was coded and analyzed thematically. Findings revealed that climate change has heightened community vulnerability, weakened their adaptive capacities, as well as disrupting the community resilience-building initiatives. In turn, communities have made attempts to respond to the challenges arising from climate change by modifying their socio-economic activities, organizing themselves internally and reverting to the use of indigenous knowledge based interventions.
Supporting employability through sport: what kind of training?
Authors: Gozzoli Caterina , Palumbo Martina , Zanoli Edgardo
Published: June 2023

Training, as a core device in the projects that use sport to increase employability, is today a much-cited element in papers in the sector. However, there seems to be little research that specifically delves into training processes. This contribution analyses the state of the art on the subject, focusing on the characteristics of the training courses mentioned in literature, highlighting some recurring critical issues. A proposal, which considers the limitations discussed above, is formulated as a result of this analysis. More specifically, we introduce, as a contribution to the debate, a training model for team sports coaches developed within the EU Erasmus + sport project SBSMED. Theoretical assumptions, methodology, contents and assessment methods of training effectiveness will be explained, highlighting valuable elements and the open issues that emerge from this experience.
Farm2Fork through the lens of community ecology: concepts and applications in postharvest storage
Authors: Gerken Alison R. , Morrison William R.
Published: June 2023

The environment in which postharvest crops are processed and stored is a dynamic ecosystem influenced not only by environmental factors such as temperature and humidity, but also by biotic influences such as humans and insects. Abiotic influences such as variation in landscapes of warehouses, processing facilities, storage and shipping containers, and urban and agricultural settings can also drive changes in ecosystem processes for insects living in a postharvest system. Principles of community ecology can help to tease apart broad interactions among the environment including succession, interactions with conspecifics that lead to competition and niche partitioning, behavioral ecology variation, and physiology and developmental changes. Focusing on these concepts for integrated pest management (IPM) for stored product insect pests can help pest managers to better predict risk thresholds and develop targeted approaches for treatments. Typically, pest management decisions focus on single species without regards to the interactions with other species. Without consideration of the entire ecosystem, targeted treatments for one species can have both direct and indirect impacts on other species that may have equally detrimental effects on stored products. Current knowledge of stored product ecosystems lags behind what is known for field pest ecosystems, and hinders our ability to design effective control strategies for the whole system. Here, we present a review of work on stored product insect pests using a community ecology lens. We analyze how the current state of the knowledge regarding species interactions and variation and incorporating factors such as movement, species interactions, energy transfer models in succession, behavior, and effects of climate change in ecological modeling can be used to better develop and implement more effective postharvest IPM. Implementing these concepts will significantly improve management of these insects and can help reduce time and cost associated with managing and treating insect infestations.
Can Litter (Dead Herbage) Management Affect the Production and Composition of a Desert Steppe Community?
Authors: Wang Jing , Wang Zhen , Yang Jianqing , Wang Zhongwu , Li Zhiguo , Zhao Mengli
Published: June 2023

To examine the effect of litter on ANPP and species composition (using ground cover) in a Desert Steppe community by removing or adding litter, during plant dormancy, in a single event in either fall or spring. Litter was removed or added in three intensity treatments (heavy, moderate, control—undisturbed) as the main plot and season (fall or spring) as the secondary treatment in a split-plot design with five replications. The experiments were repeated in each of 5 years while three of those were resampled twice. The year effect was analyzed by classifying them into high or low precipitation categories and including those in the statistical model. We found few treatment effects one year after treatment and no persistent effect. Therefore, we focus our examination on the first year only. The total ANPP of individual plant types, or their proportions, were not affected by litter treatment or its interaction with season of treatment or precipitation category. Only the ground cover of selected species was influenced by the treatment. The ground cover of Stipa breviflora was greater with heavy litter removal in fall but unaffected by litter removal in spring while Neopallasia pectinata had a greater cover with moderate or heavy removal in years when precipitation was low. Litter addition resulted in a greater ground cover of Neopallasia pectinata and reduced the cover of Convolvulus ammannii in years of low precipitation. The marginal effectiveness of litter treatments on the plan community in the Desert Steppe suggests that it need not be a factor for consideration in grazing management.
Sustainable Production of Maize with Grass and Pigeon Pea Intercropping
Authors: Fernandes Patrick Bezerra , Gonçalves Lucas Ferreira , Claudio Flavio Lopes , Souza Janayna Almeida , Júnior Guido Calgaro , Alves Estenio Moreira , Paim Tiago Do Prado
Published: June 2023

This study aimed to assess the impact of intercropping pigeon pea (Cajanus cajan cv. Super N) with maize (Zea mays cv. AG 5055) and Paiaguás palisadegrass (Urochloa brizantha cv. BRS Paiaguás) on grain yield, silage chemical composition, and post-harvest grazing forage. The experiment was conducted on the School Farm of Instituto Federal Goiano, Campus Iporá. The experiment treatments consisted of three cropping systems: pigeon pea and Paiaguás palisadegrass intercropping (PPPG), maize and Paiaguás palisadegrass intercropping (CPG), and maize, pigeon pea, and Paiaguás palisadegrass intercropping (CPPPG), respectively. It was observed after the fermentation process that the PPPG silage promoted the lowest values of forage mass (FM) and a reduction in the dry matter (DM) concentration. The PPPG silage showed higher values of crude protein (75.28 g kg−1 DM), while the CPPPG silage showed proportionately higher values of total digestible nutrients (616.11 g kg−1 DM). The intercropping did not affect the corn grain productivity, thus obtaining an average value of 4.78 Mg ha-1. After the silage harvest, during the dry season, a similar forage availability was obtained between the treatments (3.73 Mg ha−1). All three cultivation strategies produced abundant forage for grazing, showing that integrated intercropping systems can mitigate the seasonality in tropical forage production.
The Impact of Socialized Agricultural Machinery Services on the Labor Transfer of Maize Growers
Authors: Yang Siyu , Li Wei
Published: June 2023

Socialized agricultural machinery services, effectively cracking the “who to plant, how to plant” dilemma, are an important grasp of the development of modern agriculture. Based on the specialization division of labor theory, using the 2019 national survey data of maize growers in 13 provinces, the instrumental variable method and systematic generalized moment estimation (GMM) were used to overcome the endogeneity problem of mutual causality between socialized agricultural machinery services and labor transfer, analyze the impact of socialized agricultural machinery services on the labor transfer of maize growers and its link to heterogeneity, and explore the impact effect in different terrain conditions, part-time. We also explored the cohort differences in the effect in different terrain conditions and degree of part-time work. The endogenous switching regression model (ESR) was also applied to construct a counterfactual framework to further analyze the impact effect of socialized agricultural machinery services on labor transfer. The results showed that socialized agricultural machinery services could effectively promote labor transfer among maize farmers. Compared with maize farmers in other terrain conditions and part-time degree, the impact effect of agricultural machinery socialization services on labor transfer of flatland and pure farming households was more significant. Socialized agricultural machinery services play an important role in driving traditional farming households to labor transfer and realizing their organic connection with modern agriculture.
Effect of Exogenous Tryptophan on Primary Metabolism and Oxidative Stress and Their Relationship with Seedling Germination and Vigor of Glycine Max L.
Authors: Queiroz Raphael Barros , Bessa Layara Alexandre , Ávila Roniel Geraldo , Augusto Damiana Souza Santos , Oliveira Marilene Silva , Vitorino Luciana Cristina
Published: June 2023

Treatments that increase the germination potential and vigor of Glycine max seedlings are continuously being stimulated, with the aim of achieving a higher percentage of emergence and better performance in the field. Considering the relationship of tryptophan with germination-associated phytohormones, this study tested the hypothesis that exogenous supply of tryptophan to soybean seeds can affect germination, physiological vigor, and the accumulation of primary and oxidative metabolism molecules in seedlings. Soybean seeds were exposed to soaking solutions containing different concentrations of the amino acid (0, 25, 50, 100, and 200 µM), and the seedlings were evaluated at three time periods, at 8 h after sowing (HAS), and 5 and 14 days after sowing (DAS). Treated seeds showed better germination fitness and seedlings showed greater vigor, and these parameters increased with increasing concentrations of tryptophan. In the initial hours and days of germination process evaluation (14 HAS and 5 DAS), the activities of starch metabolism enzymes (α- and β-amylase) tended to be higher, resulting in increased contents of sucrose, reducing sugars, and total soluble solids at 8 DAS, constituting an important metabolic effect for seedling growth. On the other hand, the induction of germination and vigor promoted by exogenous tryptophan in soybean seedlings occurred by stimulating the metabolic pathways of oxidative stress, resulting in increased concentrations of H2O2, malondialdehyde, and proline in the tissues. Additionally, it led to increased activities of the antioxidant enzymes superoxide dismutase and ascorbate peroxidase. These parameters were responsive to increasing supplied concentrations of tryptophan. Thus, the metabolic stress in soybean seeds induced by auxin seems to be an important inductive pathway for germination and vigor of G. max seeds.
Antimicrobial Susceptibility and Resistance Mechanisms in Mannheimia haemolytica Isolates from Sheep at Slaughter
Authors: Alvarez Julio , Calderón Bernal Johan M. , Torre-Fuentes Laura , Hernández Marta , Jimenez Chris E. Pinto , Domínguez Lucas , Fernández-Garayzábal José F. , Vela Ana I. , Cid Dolores
Published: June 2023

Mannheimia haemolytica is the main pathogen contributing to pneumonic pasteurellosis in sheep. The aim of this study was to investigate the antimicrobial resistance levels in M. haemolytica isolates from the lungs of slaughtered sheep and to examine the genetic resistance mechanisms involved. A total of 256 M. haemolytica isolates, 169 from lungs with pneumonic lesions and 87 from lungs without lesions, were analyzed by the disk diffusion method for 12 antimicrobials, and the whole genome of 14 isolates was sequenced to identify antimicrobial resistance determinants. Levels of phenotypic resistance ranged from <2% for 10 antimicrobials (amoxicillin, amoxicillin-clavulanic, ceftiofur, cefquinome, lincomycin/spectinomycin, gentamicin, erythromycin, florfenicol, enrofloxacin, and doxycycline) to 4.3% for tetracycline and 89.1% for tylosin. Six isolates carried tetH genes and four isolates carried, in addition, the strA and sul2 genes in putative plasmid sequences. No mutations associated with macrolide resistance were identified in 23 rDNA sequences, suggesting that the M. haemolytica phenotypic results for tylosin should be interpreted with care in the absence of well-established epidemiological and clinical breakpoints. The identification of strains phenotypically resistant to tetracycline and of several resistance genes, some of which were present in plasmids, highlights the need for continuous monitoring of susceptibility patterns in Pasteurellaceae isolates from livestock.
Effectiveness of First-Line Therapy with Old and Novel Antibiotics in Ventilator-Associated Pneumonia Caused by Carbapenem-Resistant Acinetobacter baumannii: A Real Life, Prospective, Observational, Single-Center Study
Authors: Dalfino Lidia , Stufano Monica , Bavaro Davide Fiore , Diella Lucia , Belati Alessandra , Stolfa Stefania , Romanelli Federica , Ronga Luigi , Di Mussi Rosa , Murgolo Francesco , Loconsole Daniela , Chironna Maria , Mosca Adriana , Montagna Maria Teresa , Saracino Annalisa , Grasso Salvatore
Published: June 2023

Evidence-based, standard antibiotic therapy for ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Acinetobacter baumannii (CRAB) is a relevant unmet clinical need in the intensive care unit (ICU). We aimed to evaluate the effectiveness of first-line therapy with old and novel CRAB active antibiotics in monomicrobial VAP caused by CRAB. A prospective, observational study was performed in a mixed non-COVID-19 ICU. The primary outcome measure was clinical failure upon first-line targeted therapy. Features independently influencing failure occurrence were also investigated via Cox proportional multivariable analysis. To account for the imbalance in antibiotic treatment allocation, a propensity score analysis with an inverse probability treatment weighting approach was adopted. Of the 90 enrolled patients, 34 (38%) experienced clinical failure. Compared to patients who experienced a clinical resolution of VAP, those who had clinical failure were of an older age (median age 71 (IQR 64–78) vs. 62 (IQR 52–69) years), and showed greater burden of comorbidities (median Charlson comorbidity index 8 (IQR 6–8) vs. 4 (IQR 2–6)), higher frequency of immunodepression (44% vs. 21%), and greater clinical severity at VAP onset (median SOFA score 10 (IQR 9–11) vs. 9 (IQR 7–11)). Lower rates of use of fast molecular diagnostics for nosocomial pneumonia (8.8% vs. 30.3%) and of timely CRAB active therapy administration (65% vs. 89%), and higher rates of colistin-based targeted therapy (71% vs. 46%) were also observed in patients who failed first-line therapy. Overall, CRAB active iv regimens were colistin-based in 50 patients and cefiderocol-based in 40 patients, both always combined with inhaled colistin. According to the backbone agent of first-line regimens, clinical failure was lower in the cefiderocol group, compared to that in the colistin group (25% vs. 48%, respectively). In multivariable Cox regression analysis, the burden of comorbid conditions independently predicted clinical failure occurrence (Charlson index aHR = 1.21, 95% CI = 1.04–1.42, p = 0.01), while timely targeted antibiotic treatment (aHR = 0.40, 95% CI = 0.19–0.84, p = 0.01) and cefiderocol-based first-line regimens (aHR = 0.38, 95% CI = 0.17–0.85, p = 0.02) strongly reduced failure risk. In patients with VAP caused by CRAB, timely active therapy improves infection outcomes and cefiderocol holds promise as a first-line therapeutic option.
Lady’s Bedstraw as a Powerful Antioxidant for Attenuation of Doxorubicin-Induced Cardiotoxicity
Authors: Bradic Jovana , Andjic Marijana , Novakovic Jovana , Kocovic Aleksandar , Tomovic Marina , Petrovic Anica , Nikolic Marina , Mitrovic Slobodanka , Jakovljevic Vladimir , Pecarski Danijela
Published: June 2023

This study aimed to examine the effects of a 14-day treatment with lady’s bedstraw methanol extract on doxorubicin-induced cardiotoxicity through functional, biochemical and histological examinations. We used 24 male Wistar albino rats divided into the following groups: control (CTRL), doxorubicin (DOX), and DOX + GVE (Galium verum extract). GVE was administered orally at a dose of 50 mg/kg per day for 14 days, while a single dose of doxorubicin was injected into the DOX groups. After accomplishing treatment with GVE, cardiac function was assessed, which determined the redox state. During the autoregulation protocol on the Langendorff apparatus, ex vivo cardiodynamic parameters were measured. Our results demonstrated that the consumption of GVE effectively suppressed the disturbed response of the heart to changes in perfusion pressures caused by administration of DOX. Intake of GVE was associated with a reduction in most of the measured prooxidants in comparison to the DOX group. Moreover, this extract was capable of increasing the activity of the antioxidant defense system. Morphometric analyses showed that rat hearts treated with DOX showed more pronounced degenerative changes and necrosis compared to the CTRL group. However, GVE pretreatment seems to be able to prevent the pathological injuries caused by DOX injection via decrease in oxidative stress and apoptosis.
Magnetic Permeability Perturbation Testing for Internal Axial Cracks in Small-Diameter Thick-Walled Steel Pipes
Authors: Zhao Xueyu , Deng Zhiyang , Yu Zhiheng , Li Tingyi , Song Xiaochun
Published: June 2023

Special geometric features and complex working environments render the internal defects of small-diameter thick-walled steel pipes “easy to expand, difficult to detect”. In this paper, a magnetic permeability perturbation testing (MPPT) method is proposed to assess the internal axial cracks of small-diameter thick-walled steel pipes. The mechanism of the MPPT method and its corresponding probe and magnetizer are introduced, and its feasibility is verified through a series of simulations and experiments. Experiments conducted using different sizes of small-diameter thick-walled pipes show that this method offers good performance with respect to the detection of internal axial cracks. Additionally, both diameter and wall thickness significantly affect the MPPT signal. To a certain extent, a greater wall thickness or a smaller diameter brings about a weaker signal. This method does not benefit from the lift-off effect, nor is it limited by the skin effect, which has great practical value as a supplement to the evaluation of thick-walled steel pipes.
Development of Fast Protection System with Xilinx ZYNQ SoC for RAON Heavy-Ion Accelerator
Authors: Nam Seung-Hee , Son Changwook , Bahng Jungbae
Published: June 2023

The development of the fast protection system (FPS) was driven by the critical need to safeguard internal components of the accelerator from beam damage and minimize operational downtime. During accelerator operation, various faults can occur, posing a significant risk. The FPS acts as a rapid response system, initiating a shutdown signal to a reliable chopper system to prevent beam damage and ensure the operational availability of the accelerator. To meet the stringent shut off time requirements specific to critical faults, the FPS was designed to respond within 50 µs, while the total FPS time, including acquisition, redundancy, and processing, needed to be less than 20 µs. In order to achieve these goals, a customized FPS was developed for the RAON heavy-ion accelerator, utilizing the Xilinx ZYNQ system-on-chip (SoC). The FPS system comprised seven acquisition modules, one mitigation module with an embedded SoC, and employed optical fiber connections for efficient data transmission. This article provides a comprehensive account of the design, development, and testing of the FPS system. Experimental tests were conducted to validate its performance. These tests included verifying the accuracy of cyclic redundancy checks, acquiring interlock signals in short pulses, and measuring the delay time during abnormal signal occurrences. Of particular significance is the measurement of the total signal processing time for a 1 km optical cable in the RAON system, which was determined to be 9.8 µs. This result successfully met the stringent requirement of 20 µs for the FPS time. The ability of the FPS to operate within the desired time frame demonstrates its effectiveness in protecting the accelerator’s components from beam damage and minimizing downtime. Consequently, the FPS ensures the operational availability of the accelerator while maintaining the safety and integrity of its internal systems. By providing a detailed account of the FPS’s design, development, and testing, this article contributes valuable insights into the capabilities of the FPS in real-world accelerator scenarios. The successful implementation of the RAON-optimized FPS with the Xilinx ZYNQ SoC reaffirms its effectiveness as a fast and reliable protection system, thus enhancing the overall operational performance of the accelerator.
Arbitrary-Order Sensitivity Analysis of Eigenfrequency Problems with Hypercomplex Automatic Differentiation (HYPAD)
Authors: Velasquez-Gonzalez Juan C. , Navarro Juan David , Aristizabal Mauricio , Millwater Harry R. , Montoya Arturo , Restrepo David
Published: June 2023

The calculation of accurate arbitrary-order sensitivities of eigenvalues and eigenvectors is crucial for structural analysis applications, including topology optimization, system identification, finite element model updating, damage detection, and fault diagnosis. Current approaches to obtaining sensitivities for eigenvalues and eigenvectors lack generality, are complicated to implement, prone to numerical errors, and are computationally expensive. In this work, a novel methodology is introduced that uses hypercomplex automatic differentiation (HYPAD) and semi-analytical expressions to obtain arbitrary-order sensitivities for eigenfrequency problems. The new methodology exhibits no sign of truncation nor subtractive cancellation errors regardless of the order of the sensitivity, it is general, and can obtain any high-order sensitivities with the simplicity of first-order computations. A numerical example is presented to verify the accuracy of the method, where the free vibration of a homogeneous cantilever beam is studied. For this problem, up to third-order sensitivities of the eigenvalues and eigenvectors with respect to the material and geometrical parameters were obtained, considering the cases of close and distinct eigenvalues. The results were verified using analytical equations, showing excellent agreement for the eigenvalues and the eigenvectors. The new method promises to facilitate the computation of sensitivities for eigenfrequency problems into routine practice and commercial software.
The Potential for the Implementation of Pea Flower (Clitoria ternatea) Health Properties in Food Matrix
Authors: Shirodkar Shwetali Mahesh , Multisona Ribi Ramadanti , Gramza-Michalowska Anna
Published: June 2023

Clitoria ternatea is a revered flower and plant in botanical science. While its health benefits are only recently gaining popularity, the plant itself has been the recipient of many traditional and indigenous medicines, including that of Ayurvedic medicine in South Asia. The peculiar property of this flower is its ability to change color depending on its pH. This review article encompasses the literature surrounding this plant and its valuable flower and attempts to cover all aspects of its benefits in the food matrix, including its existing applications. It also aims to look at the flower from a holistic perspective and imagine it as a source of future food.
Hyperspectral Image Classification Based on Fusion of Convolutional Neural Network and Graph Network
Authors: Gao Luyao , Xiao Shulin , Hu Changhong , Yan Yang
Published: June 2023

Convolutional neural networks (CNNs) have attracted significant attention as a commonly used method for hyperspectral image (HSI) classification in recent years; however, CNNs can only be applied to Euclidean data and have difficulties in dealing with relationships due to their limitations of local feature extraction. Each pixel of a hyperspectral image contains a set of spectral bands that are correlated and interact with each other, and the methods used to process Euclidean data cannot effectively obtain these correlations. In contrast, the graph convolutional network (GCN) can be used in non-Euclidean data but usually leads to over-smoothing and ignores local detail features due to the need for superpixel segmentation processing to reduce computational effort. To overcome the above problems, we constructed a fusion network based on the GCN and CNN which contains two branches: a graph convolutional network based on superpixel segmentation and a convolutional network with an added attention mechanism. The graph convolutional branch can extract the structural features and capture the relationships between the nodes, and the convolutional branch can extract detailed features in the local fine region. Owing to the fact that the features extracted from the two branches are different, the classification performance can be improved by fusing the complementary features extracted from the two branches. To validate the proposed algorithm, experiments were conducted on three widely used datasets, namely Indian Pines, Pavia University, and Salinas. An overall accuracy of 98.78% was obtained in the Indian Pines dataset, and overall accuracies of 98.99% and 98.69% were obtained in the other two datasets. The results show that the proposed fusion network can obtain richer features and achieve a high classification accuracy.
Hydrothermal Fabrication of GO Decorated Dy2WO6-ZnO Ternary Nanocomposites: An Efficient Photocatalyst for the Degradation of Organic Dye
Authors: Selvakumar Karuppaiah , Oh Tae Hwan , Arunpandian Muthuraj , Aruchamy Kanakaraj , Polisetti Veerababu
Published: June 2023

Environmental and human health are seriously threatened by organic dye pollution. Many efforts have been made to find effective and safe methods of eliminating these contaminants. To mitigate these effects, the hydrothermal method was used to effectively generate a ternary kind of Dy2WO6-ZnO embedded in graphene oxide (DWZG) nanocomposites, which were used to degrade the pollutant. Powder X-ray diffraction (XRD) investigation confirms the crystalline character of the as-prepared DWZG nanocomposite. The Dy2WO6-ZnO composition on the graphene oxide (GO) layer is shaped like a combination of algae (Dy2WO6) and clusters (ZnO), as shown by scanning electron microscopy (SEM). X-ray photoelectron spectroscopy (XPS) investigation revealed the composition of elements and oxidation state of C, Dy, O, W and Zn elements. Methylene blue (MB) was chosen as the organic dye target for photocatalytic degradation using the produced nanocomposites. MB is degraded with a photocatalytic efficiency of 98.2% in about 30 min using a DWZG catalyst. Based on the result of the research entitled “Reactive Oxidative Species,” the primary reactive species involved in the MB degradation are photo-generated •OH and O2•− radicals. The recycle test was also successful in evaluating the catalysts’ long-term viability as well as their reusability.
HapticSOUND: An Interactive Learning Experience with a Digital Musical Instrument
Authors: Volioti Christina , Tsagaris Apostolos , Trigkas Dimitrios , Iliou Theodoros , Katsantonis Menelaos N. , Mavridis Ioannis
Published: June 2023

In this paper, an interactive learning experience is proposed, aiming to involve museum visitors in a personalized experience of the transmittal of cultural knowledge in an active and creative way. The proposed system, called HapticSOUND, consists of three subsystems: (a) the Information, where visitors are informed about the traditional musical instruments; (b) the Entertainment, where visitors are entertained by playing serious games to virtually assemble traditional musical instruments by a set of 3D objects; and (c) the Interaction, where visitors interact with a digital musical instrument which is an exact 3D-printed replica of a traditional musical instrument, where cameras have been placed to capture user gestures and machine learning algorithms have been implemented for gesture recognition. The museum visitor can interact with the lifelike replica to tactilely and aurally explore the instrument’s abilities, producing sounds guided by the system and receiving real-time visual and audio feedback. Emphasis is given to the Interaction Subsystem, where a pilot study was conducted to evaluate the usability of the subsystem. Preliminary results were promising since the usability was satisfactory, indicating that it is an innovative approach that utilizes sensorimotor learning and machine learning techniques in the context of playing sounds based on real-time gesture and fingering recognition.
Empirical Proof of the Characteristics of the Queue Discharge Rate under Different Rainfall Conditions on an Active On-Ramp Bottleneck
Authors: Mejia Hanzel , Karoonsoontawong Ampol , Kanitpong Kunnawee
Published: June 2023

Empirical studies show that queue discharge rate is lower than pre-queue capacity in congestion. This is the the capacity drop phenomenon. All previous research about this event used data during clear weather conditions. This is the first time that empirical relationships between queue discharge rate and weather conditions have been studied. Previous studies show that the capacity drop is triggered by a critical density. Once this density is reached, a drop in the discharge rate is expected. We show that this critical density decreases during any weather condition. Previous studies also prove that the capacity drop is related to speed in congestion but that this might not be true during inclement weather. We show that queue discharge rate is correlated to the speed of congestion in any weather condition. We have also shown for the first time that the speed in congestion and the percentage of the capacity drop have a negative linear relationship.
Archaeometric Study of the Mural Paintings by Saturnino Gatti and Workshop in the Church of San Panfilo, Tornimparte (AQ): The Study of Organic Materials in Original and Restored Areas
Authors: Andreotti Alessia , Izzo Francesca Caterina , Bonaduce Ilaria
Published: June 2023

In the context of the archaeometrical study of Saturnino Gatti’s wall paintings, a significant aspect concerned the study of the organic component to understand both the original binders used in the original areas and the products used for pictorial reintegration and restoration of the painted surfaces. Thanks to the results obtained from various non-invasive and multi-band imaging techniques, it was possible to define Gatti’s original painting technique and identify the materials subsequently applied in significant samples. To this end, molecular analyses based on mass spectrometry were carried out. Different procedures in gas chromatography–mass spectrometry (GC-MS) and in pyrolysis coupled with gas chromatography–mass spectrometry (Py-GC-MS) were adopted. The analyses revealed a variety of organic materials on the mural paintings, most of which are from past restoration interventions and have synthetic origin. The overspread presence of paraffin is likely due to the application of a mineral wax-based coating/consolidant. In particular, the execution technique encompassed the use of tempera-based paints, while retouched areas were characterised by the presence of oil-based resins.
Bacillus velezensis Strain HN-Q-8 Induced Resistance to Alternaria solani and Stimulated Growth of Potato Plant
Authors: Bai Xuefei , Li Qian , Zhang Dai , Zhao Yi , Zhao Dongmei , Pan Yang , Wang Jinhui , Yang Zhihui , Zhu Jiehua
Published: June 2023

Bacillus velezensis HN-Q-8, isolated in our previous study, has an antagonistic effect on Alternaria solani. After being pretreated with a fermentation liquid with HN-Q-8 bacterial cell suspensions, the potato leaves inoculated with A. solani displayed smaller lesion areas and less yellowing than the controls. Interestingly, the activity levels of superoxide dismutase, peroxidase, and catalase in potato seedlings were enhanced by the addition of the fermentation liquid with bacterial cells. Additionally, the overexpression of key genes related to induced resistance in the Jasmonate/Ethylene pathway was activated by the addition of the fermentation liquid, suggesting that the HN-Q-8 strain induced resistance to potato early blight. In addition, our laboratory and field experiments showed that the HN-Q-8 strain can promote potato seedling growth and significantly increase tuber yield. The root activity and chlorophyll content of potato seedlings were significantly increased along with the levels of indole acetic acid, gibberellic acid 3, and abscisic acid upon addition of the HN-Q-8 strain. The fermentation liquid with bacterial cells was more efficient in inducing disease resistance and promoting growth than bacterial cell suspensions alone or the fermentation liquid without bacterial cells. Thus, the B. velezensis HN-Q-8 strain is an effective bacterial biocontrol agent, augmenting the options available for potato cultivation.
Alzheimer’s Disease and Age-Related Changes in the Cu Isotopic Composition of Blood Plasma and Brain Tissues of the APPNL-G-F Murine Model Revealed by Multi-Collector ICP-Mass Spectrometry
Authors: Hobin Kasper , Costas-Rodríguez Marta , Van Wonterghem Elien , Vandenbroucke Roosmarijn E. , Vanhaecke Frank
Published: June 2023

Alzheimer’s’ disease (AD) is characterized by the formation of β-amyloid (Aβ) plaques and neurofibrillary tangles of tau protein in the brain. Aβ plaques are formed by the cleavage of the β-amyloid precursor protein (APP). In addition to protein aggregations, the metabolism of the essential mineral element Cu is also altered during the pathogenesis of AD. The concentration and the natural isotopic composition of Cu were investigated in blood plasma and multiple brain regions (brain stem, cerebellum, cortex, and hippocampus) of young (3–4 weeks) and aged (27–30 weeks) APPNL-G-F knock-in mice and wild-type controls to assess potential alterations associated with ageing and AD. Tandem inductively coupled plasma-mass spectrometry (ICP-MS/MS) was used for elemental analysis and multi-collector inductively coupled plasma-mass spectrometry (MC-ICP-MS) for high-precision isotopic analysis. The blood plasma Cu concentration was significantly altered in response to both age- and AD-related effects, whereas the blood plasma Cu isotope ratio was only affected by the development of AD. Changes in the Cu isotopic signature of the cerebellum were significantly correlated with the changes observed in blood plasma. The brain stem showed a significant increase in Cu concentration for both young and aged AD transgenic mice compared with healthy controls, whereas the Cu isotopic signature became lighter as a result of age-related changes. In this work, ICP-MS/MS and MC-ICP-MS provided relevant and complementary information on the potential role of Cu in ageing and AD.
Unraveling the Immune Microenvironment in Classic Hodgkin Lymphoma: Prognostic and Therapeutic Implications
Authors: Georgoulis Vasileios , Papoudou-Bai Alexandra , Makis Alexandros , Kanavaros Panagiotis , Hatzimichael Eleftheria
Published: June 2023

Classic Hodgkin lymphoma (cHL) is a lymphoid neoplasm composed of rare neoplastic Hodgkin and Reed–Sternberg (HRS) cells surrounded by a reactive tumor microenvironment (TME) with suppressive properties against anti-tumor immunity. TME is mainly composed of T cells (CD4 helper, CD8 cytotoxic and regulatory) and tumor-associated macrophages (TAMs), but the impact of these cells on the natural course of the disease is not absolutely understood. TME contributes to the immune evasion of neoplastic HRS cells through the production of various cytokines and/or the aberrant expression of immune checkpoint molecules in ways that have not been fully understood yet. Herein, we present a comprehensive review of findings regarding the cellular components and the molecular features of the immune TME in cHL, its correlation with treatment response and prognosis, as well as the potential targeting of the TME with novel therapies. Among all cells, macrophages appear to be a most appealing target for immunomodulatory therapies, based on their functional plasticity and antitumor potency.
High PD-L1 Expression Correlates with an Immunosuppressive Tumour Immune Microenvironment and Worse Prognosis in ALK-Rearranged Non-Small Cell Lung Cancer
Authors: Tian Xia , Li Yalun , Huang Qin , Zeng Hao , Wei Qi , Tian Panwen
Published: June 2023

High tumour programmed cell death-ligand 1 (PD-L1) expression is associated with poor progression-free survival (PFS) after tyrosine kinase inhibitor (TKI) therapy in ALK-rearranged non-small cell lung cancer (NSCLC). However, the characteristics of the tumour microenvironment (TME) and their prognostic values in ALK-rearranged NSCLC are unknown. Here, we collected tumour tissues from pretreated ALK-rearranged NSCLC patients, immunohistochemical staining was used to assess PD-L1 expression, and tumour-infiltrating immune cells were determined via multiplex immunofluorescence staining (mIF). Our data showed that the median values of PFS for the high PD-L1 group and low PD-L1 group who received ALK-TKI treatment were 4.4 and 16.4 months, respectively (p = 0.008). The median overall survival (OS) of the two groups was 24.0 months and not reached, respectively (p = 0.021). Via univariate and multivariate analyses, a high PD-L1 expression and a worse ECOG PS were determined to be independent prognostic factors of OS (HR = 3.35, 95% CI: 1.23–9.11, p = 0.018; HR = 6.42, 95% CI: 1.45–28.44, p = 0.014, respectively). In addition, the high PD-L1 group had increased Tregs and exhausted CD8+ T cells in both the tumour and stroma (all p < 0.05). High PD-L1 expression was an adverse predictive and prognostic biomarker for ALK-rearranged NSCLC. The characteristics of the TME in patients with high PD-L1 expression were shown to have an immunosuppressive status.