bluuebunny/crossref_metadata_2025 huggingface dataset:
FEATURES OF BRONCHIAL ASTHMA CONTROL AND COURSE IN CHILDREN WITH AN ALTERNATIVE ONSET OF THE DISEASE
Authors: Koloskova О.К. , Bilous Т.М. , Shevchenko N.O. , Bilous V.V.
Published: March 2021

Despite the large number of studies on the diagnosis and treatment of asthma and the constant updating of recommendations for the provision of medical care to patients with asthma, this disease still has a significant impact on the quality of life of patients and their families and significant economic losses. However, the peculiarities of bronchial asthma and the diagnosis of certain phenotypes of the disease in children, depending on biomarkers of inflammatory activity in the airways, require greater use of non-invasive diagnostic procedures and optimization of individualized treatment depending on the nature and intensity of inflammation in the respiratory tract.
MODERN METHODS OF SURGICAL TREATMENT OF PERIPHERAL NERVOUS SYSTEM INJURIES
Authors: Potapov O.O. , Kmyta O.P. , Tsyndrenko O.O. , Semenyuk M.I. , Senchenko A.V.
Published: March 2021

In Ukraine, 2,500–3,000 people sustain peripheral nerve injuries every year. Often these are young people of working age. In the structure of total injuries, peripheral nerve damage in peacetime makes 1.5–6%, and during military operations (taking into account the situation in the east of Ukraine), this value ranges from 9 to 25% due to gunshot injuries.
Analysis of medical literature and publications over the past five years was carried out, with due attention to the studies related to modern surgical treatment methods of peripheral nerve traumatic injuries.
The problem of surgical treatment has not been thoroughly studied. Peripheral nerve regeneration is a complex process, and therefore the existing treatment methods are limited due to slow nerve regeneration and insufficient spanning of large post-traumatic nerve defects. To overcome these limitations, a cell therapy has been developed that ensures the presence of supporting cells at the site of the lesion in order to accelerate nerve regeneration. Schwann cells play an important role in many aspects of nerve regeneration. Stem cell transplantation for peripheral nerve regeneration represents alternative cell therapy with several regenerative benefits. Various types of stem cell sources are currently being investigated for use for peripheral nerve regeneration in combination with the most optimal nerve guide conduit.
FEATURES OF THE COURSE OF MULTIPLE PREGNANCY AGAINST THE BACKGROUND OF FETAL GROWTH RETARDATION
Authors: Sukharev A.B. , Kopytsia T.V. , Boyko V.I.
Published: March 2021

In most European countries in recent years, the frequency of multiple births ranges from 11 to 14 per 1000. These pregnancies have a high number of complications. Perinatal mortality in multiple births is more than 6 times higher than in singleton pregnancies. Severe neurological abnormalities under the age of 1 year have from 10% to 25% of twins. According to most researchers, the main cause of perinatal losses in multiple births is deep prematurity and severe fetal growth delay. It has now been proven that placental insufficiency is the main reason of developmental delay, discordant fetal growth, antenatal death of one of the fetuses. A fetus that develops and is born in conditions of chronic placental insufficiency is more vulnerable and at high risk of developing perinatal pathology.
The purpose of the research was to study the frequency and structure of complications of the pregnancy and labor of women with multiple pregnancies, complicated uteroplacental insufficiency and fetal discordance.
The study was carried out at the city clinical maternity house during 2013–2019. The information was gathered from literature and by interviewing pregnant women with twins. 20 pregnant women (group I) with dichorionic, diamnionic twins with the presence of placental insufficiency and fetal discordance of more than 20%. Group II consisted of 20 pregnant women with twins but fetal discordance did not exceed 20%. However, the control group ІІІ consisted of 30 women without complications and ended in physiological labor. The general, somatic, obstetric and gynecological anamnesis, especially the course of pregnancy, childbirth, the state of the cervix by vaginal and ultrasound examination were studied.
The results of the study show that in the anamnesis of pregnant women with fetal discordance, take place in vitro fertilization and infections of the respiratory and urinary tract. Multiple pregnancies which were accompanied by fetal discordance exceeding 20% ​​is accompanied by impaired uteroplacental circulation. Labor with twins complicated by impaired uteroplacental circulation occurs in a large number of complications. The results can be applied to the using various medications for the correction of disorders of the uteroplacental circulation.
CORRELATIONS OF CARDIOVASCULAR INDICATORS IN INSULIN-DEPENDENT DIABETES IN CHILDREN
Authors: Maidannyk V.G. , Kryvonos Y.M. , Mityriaeva-Korniiko I.O. , Gnyloskurenko G.V. , Romanenko S.Y. , Saltyikova G.V. , Terletskyi R.V.
Published: March 2021

In the study we examined children with type 1 diabetes, aged 8 to 17 years, divided into groups depending on the duration of the disease (up to 5 years and over 5 years) in order to study the electrocardiographic changes by daily Holter ECG monitoring depending on the duration of the disease, glycaemia and insulin therapy. Holter ECG monitoring was performed by ECG monitoring complex “DiaCard” ("SOLVAIG" JSC, Kyiv, Ukraine). During the monitoring, the subjects kept a diary of activity with a record of the symptoms, time and dose of insulin and other drugs, as well as indicators of glycaemia, time and quality of sleep. In addition to arrhythmias and conduction parameters, standard parameters of the whole ECG were determined, including ST segment analysis, as well as QT and QT corrected intervals and their dispersion. All ECG parameters per day were evaluated in comparison with the normative values of heart rate in healthy children according to sex and age. The results indicate that regardless of the duration of the disease, there are cardiac dysrhythmias, mainly associated with changes in the automatism of the sinus node and increased activity of ectopic foci of rhythm, which weakens the parasympathetic effects on the heart. Correlation analysis of the detected ECG changes in patients confirmed the progressive effect of the sympathetic part of the autonomic nervous system on heart rate, the relationship of glycaemia with repolarization of ventricles and heart rate, cardiac arrhythmias with changes in sleep structure and awakening according to heart rate. These data can be used to optimize the diagnosis of diabetic heart disease in children and to identify patients who need close attention from cardiologists.
Simulation model of the transmission path for 5G NR base station
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Movchan A. K. , Rogozhnikov E. V. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Dmitriev E. M. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Novichkov S. A. ,   Skolkovo Institute of Science and Technology (Skoltech), Lakontsev D. V. ,   Skolkovo Institute of Science and Technology (Skoltech)
Published: March 2021

The article presents the results of modeling an analog radio path of a fifth-generation cellular base station in the NI AWR Design Environment. The validation of the power amplifier model was performed in the AWR software environment. The validation is based on the comparison of measurement results for the nonlinear parameters of the amplitude characteristics of the microwave amplifier obtained on the amplifier model, with the results obtained during mathematical modeling of the nonlinear amplifier. The results of measuring the vector magnitude error between the input and output signals in the radiopath model are presented.
Resonant solar cell energy converter in the power supply system for small spacecraft
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Zhuravlev I. M. , Osipov A. V. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR)
Published: March 2021

The operation of a solar cell resonant converter at operating modes in the power supply system of a small spacecraft is investigated. The resonant converter with pulse-code regulation simulation model has been developed, and the operation point by stabilizing charge current mode and stabilizing output voltage mode is considered. The converter regulating characteristics in various operating modes are obtained.
Adaptation strategies for rainfed rice water management under climate change in Songkhram River Basin, Thailand
Authors: Boonwichai Siriwat , Shrestha Sangam , Pradhan Pragya , Babel Mukand S. , Datta Avishek
Published: March 2021

This study investigates the potential impacts of climate change on water resources and evaluates adaptation strategies on rainfed rice water management under climate change scenarios in the Songkhram River Basin, Thailand. The Soil and Water Assessment Tool (SWAT) model was used to project the future water availability under climate change scenarios for the period of 2020–2044. Future annual water availability is expected to remain unchanged due to unchanged future rainfall but expected to reduce from June to November due to changes in seasonal rainfall. The effects of supplying irrigation water to reduce the impact of climate change and increase rainfed rice production were evaluated. To increase the rice production by 15%, it is proposed to construct a reservoir with a capacity of below 65 MCM in each of the 15 sub-basins to fulfill the irrigation water requirements during the rainfed rice season. Alternatively, adaptation at the farm scale can be implemented by constructing ponds with a capacity of 900 m3 to store water for 1 ha of rice field to meet the potential rice yield during the non-rainfed rice season. The results of this study are helpful to policymakers in understanding the potential impacts of climate change and the formulation of adaptation strategies for water and rice sectors in the basin.
Treatment of wastewater from a dairy plant by adsorption using synthesized copper oxide nanoparticles: kinetics and isotherms modeling optimization
Authors: Al-Ananzeh Nada M.
Published: March 2021

Dairy plants produce 1 to 4 L of wastewater per 1 L of processed milk. The wastewater contains high values of chemical oxygen demand (COD) and biochemical oxygen demand (BOD) concentrations, in addition to high levels of dissolved solids. In this study, synthesized copper oxide nanoparticles (CuONPs) coupled with Sophora Japonica fruit, were used as an adsorbent, for the first time, to treat the effluent of dairy plants in a batch adsorption process. The analysis techniques, Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and scanning electron microscopy (SEM) were utilized to characterize the adsorbent. The COD removal, using (CuONPs)-based adsorbent, was investigated by varying contact time, masses of the adsorbent, initial COD value and temperatures. The optimum conditions for highest removal percentage were contact time of 120 min, a temperature of 25 °C, pH value of 7.5, and 1 g of adsorbent. The initial COD values used were in the range of 100–700 ppm. The COD percent removal was in the range of 77 to 95%. Freundlich isotherm exhibited the best fitting for the results (R2 = 0.998) with a favorable spontaneous exothermic adsorption process. Based on the calculated normalized deviation value, the modified diffusion model, intra-diffusion, and pseudo-second-order kinetics all showed very good fitting for the adsorption data as indicated by the kinetics study.
Phytochemical Screening, In vitro Antioxidant and Enzyme Inhibitory
Properties, and Acute Toxicity of Extracts from the Aerial Parts of
Ephedra nebrodensis, a Source of Bioactive Compounds
Authors: Hamoudi Meriem , Amroun Djouher , Boutefnouchet Sabrina , Bensouici Chawki , Kaoula Samira , Harzallah Daoud , Khennouf Seddik , Dahamna Saliha
Published: March 2021

Background:

Due to the strong association between the chemistry of medicinal plants
and their biological properties, it is important to determine their phytochemical composition to
justify experimental tests.

Objective:

The aim of this study was to evaluate the in vitro antioxidant and the enzyme inhibitory
properties and to identify the bioactive compounds present in the extracts of Ephedra nebrodensis
growing in Algeria.

Methods:

Total phenolic and flavonoids content in these extracts were quantified by Folin-
Ciocalteu and aluminum chloride methods. The antioxidant capacity was assessed using DPPH,
ABTS, β-carotene/linoleic acid, CUPRAC and FRAP assays, and in vitro cholinesterase activity
against acetylcholinesterase and butyrylcholinesterase were evaluated. The chemical constituents
of the extracts were analyzed by high-performance liquid chromatography coupled with mass
spectrometric detection and gas chromatography. For the acute toxicity study, extracts were
administered to mice at single dose of 2 g/kg and 5 g/kg by gavage.

Results:

Plant extracts were rich in phenolic compounds. Ethyl acetate extract presented the
highest phenolic (238.44 ± 1.50 μg GAE /mg of extract) and flavonoid (21.12 ± 0.00 μg QE /mg
of extract) contents. Likewise, ethyl acetate extract showed potent radical scavenging and reducing
properties. Ethanol-acetone extract showed inhibitory activity against acetylcholinesterase, and
was a potent inhibitor of butyrylcholinesterase. In all extracts, flavonoids were the most abundant
compounds. The phytochemical investigation showed the presence of alkaloids (ephedrine and
pseudo-ephedrine). In the acute toxicity, the LD50 was superior to 5 g/kg body weight. There were
no alterations in the histology of the liver and kidneys.

Conclusion:

This study demonstrated a good antioxidant potential and anticholinesterase activity
of aerial parts of E. nebrodensis.
Coumarin-1,2,3-triazole Hybrid Molecules: An Emerging Scaffold for Combating Drug Resistance
Authors: Upadhyay Harish C.
Published: March 2021

Undoubtedly, antibiotics have saved billions of lives, but lack of novel antibiotics, development of resistance mechanisms in almost all clinical isolates of bacteria, and recurrent infections caused by persistent bacteria hamper the successful treatment of the infections. Due to the widespread emergence of resistance, even the new families of anti-microbial agents have a short life expectancy. Drugs acting on a single target often lead to drug resistance and are associated with various side effects. For overcoming this problem, either multidrug therapy, or a single drug acting on multiple targets may be used. The latter is called ‘hybrid molecules,’ which are formed by clubbing two biologically active pharmacophores together, with or without an appropriate linker. In this rapidly evolving era, the development of natural product-based hybrid molecules may be a super-alternative to multidrug therapy, for combating drug resistance caused by various bacterial and fungal strains. Coumarins (benzopyran-2-one) are one of the earliest reported plant secondary metabolites having a clinically proven diverse range of pharmacological properties. On the other hand, 1,2,3-triazole is a common pharmacophore in many drugs responsible for polar interactions, improving the solubility and binding affinity to biomolecular targets. In this review, we discuss recent advances in Coumarin-1,2,3-triazole hybrids as potential anti-bacterial agents, aiming to provide a useful platform for the exploration of new leads with a broader spectrum, more effectiveness and less toxicity with multiple modes of action for the development of cost-effective and safer drugs in the future.
Various Müllerian-duct Anomalies in Women at Rural Tertiary Care Center
of Northern India: An Observational Study
Authors: Kumar Naina , Yadav Ashu
Published: March 2021

Aims:

Present study was conducted to know presentations and nature of Müllerian-duct anomalies in rural women.

Background:

Müllerian anomalies are congenital defects of female reproductive tract resulting from faulty development and fusion of Müllerian ducts.

Objectives:

To identify common Müllerian anomalies, their presentation, radiological appearances, complications, associated renal anomalies in rural women of Northern India.

Methods:

Present observational study was conducted on 181 female patients with suspected Müllerian anomalies presenting to the outpatient department of Obstetrics and Gynecology with various complaints. Data included age, religion, menarche, previous pregnancy if any, duration of infertility, presenting complaints, type of Müllerian anomaly, incidental or symptomatic, diagnostic method, associated anomalies. Statistical analysis was done using SPSS 22.0 version software. Results: Of 181 patients, 16.5% were adolescents, 83.5% adult women with an overall mean (SD) age of 25.02 (5.96) years. Of these, 170 had true Müllerian-duct anomalies and 11 had defects other than Müllerian anomalies, hence excluded. Total 158(92.9%) patients were symptomatic and 12(7.1%) asymptomatic at presentation. The majority (75.9%) were diagnosed incidentally during their visit to the department for various complaints of which infertility (32.4%) was most common. Septate uterus (29.4%) was most common anomaly diagnosed followed by Müllerian agenesis/hypoplasia (22.9%). Around 11.2% cases had associated renal and collecting system anomalies with unilateral renal agenesis (47.4%) being most common.

Results:

Of 181 patients, 16.5% were adolescents, 83.5% adult women with an overall mean (SD) age of 25.02 (5.96) years. Of these, 170 had true Müllerian-duct anomalies and 11 had defects other than Müllerian anomalies, hence excluded. Total 158(92.9%) patients were symptomatic and 12(7.1%) asymptomatic at presentation. The majority (75.9%) were diagnosed incidentally during their visit to the department for various complaints of which infertility (32.4%) was most common. Septate uterus (29.4%) was most common anomaly diagnosed followed by Müllerian agenesis/hypoplasia (22.9%). Around 11.2% cases had associated renal and collecting system anomalies with unilateral renal agenesis (47.4%) being most common.

Conclusion:

Hence, Müllerian-duct anomalies have diverse presentations and most of them are diagnosed incidentally. Other: The exact prevalence of Müllerian-duct anomalies may be high, especially in rural India due to lack of knowledge and societal pressures.
Conifer Essential Oils Reversed Amyloid Beta1-42 Action by Modulating
BDNF and ARC Expression in The Rat Hippocampus
Authors: Postu Paula Alexandra , Tiron Adrian , Tiron Crina Elena , Gorgan Dragoș Lucian , Mihasan Marius , Hritcu Lucian
Published: March 2021

Background:

The conifer species Pinus halepensis (Pinaceae) and Tetraclinis articulata
(Cupressaceae) are widely used in traditional medicine due to their beneficial health properties.

Objective:

This study aimed to investigate the mechanisms by which P. halepensis and T. articulata
essential oils (1% and 3%) could exhibit neuroprotective effects in an Alzheimer's disease
(AD) rat model, induced by intracerebroventricular (i.c.v.) administration of amyloid beta1-42
(Aβ1-42).

Method:

The essential oils were administered by inhalation to the AD rat model, once daily, for 21
days. DNA fragmentation was assessed through a Cell Death Detection ELISA kit. Brain-derived
neurotrophic factor (BDNF), activity-regulated cytoskeleton-associated protein (ARC), and interleukin-
1β (IL-1β) gene expressions were determined by RT-qPCR analysis, while BDNF and ARC
protein expressions were assessed using immunohistochemistry technique.

Results:

Our data showed that both essential oils substantially attenuated memory impairments,
with P. halepensis mainly stimulating ARC expression and T. articulata mostly enhancing BDNF
expression. Also, the inhalation of essential oils reduced IL-1β expression and induced positive effects
against DNA fragmentation associated with Aβ1-42-induced toxicity, further contributing to
the cognitive improvement in the rats with the AD-like model.

Conclusion:

Our findings provide further evidence that these essential oils and their chemical constituents
could be natural agents of therapeutic interest against Aβ1-42-induced neurotoxicity.
In Silico Analysis of Drug Repurposing Strategy for the Identification of Potential NS3 Helicase Inhibitors Against Zika Virus
Authors: Loganathan Lakshmanan , Carlus S. Justin , Muthusamy Karthikeyan
Published: March 2021

Background:

Ancestral recapitulation of the Zika virus from Uganda, Africa, an epidemic
in American territories since 2015, was reported by CDC, 2016. To date, there is no specific vaccine
or drug for the Zika virus.

Objective:

The study aims to identify the potential inhibitors that have the capability to be effective
against Zika virus. Natural and FDA-approved anti-viral drug molecules are utilized through the drug
repurposing approach to screen the lead compounds.

Method:

Molecular docking approach was utilized to screen the best hit compounds. The identified
compounds were further evaluated through binding free energy calculations and physiochemical
properties. Density functional theory calculations were calculated for the best hit compounds to observe
the structural properties and electrophilic/nucleophilic attack at the quantum level. Furthermore,
molecular dynamic simulation studies provide insight into structural stability and conformational
analysis of the protein and ligand molecules.

Result:

Non-covalent interactions observed between the molecules are Gly199, Lys200, Thr201,
Arg202, Asn417, Glu231, Glu286, and Arg459. Telaprevir, a Hepatitis C virus (NS3/4 protease)
inhibitor, and Curcuma Longa, a natural drug, are found to be more potent druggable candidates
among the screened leads for the Zika virus.

Conclusion:

The results of the study suggest Telaprevir and Curcuma Longa to be considered as the
lead agents for experimental studies on Zika virus. The outcome of the study may provide much
knowledge in designing anti-zika drugs in the future.
Dar al-Islam / Dar al-Harb: Categories of Space in Medieval Islam
Authors:   Peter the Great Museum of Anthropology and Ethnography (Kunstkamera), RAS, Konstantin Sergeevich Vasiltsov
Published: March 2021

The article deals with some issues related to the conception of space/territory in medieval Islam. At the turn of XX–XXI centuries within the framework of various humanitarian disci-plines has been widely discussed a new understanding of space which came to be realized as a heterogeneous social and cultural phenomenon, reflecting political, legal and social norms spe-cific to a particular culture. At the first centuries of the history of Islam there appeared the idea of two geo-religious regions: Dar al-Islam ("Territory of Islam") and Dar al-Harb (Territory of war) or otherwise Dar al-Kufr ("Territory of unbelief"). On the one hand, these concepts reflect the real boundaries of the Muslim / non-Muslim world and the criteria by which those belonging to it were determined, and at the same time it contains an indication of certain non-spatial cultur-al symbols, categories and values. Special attention here is paid to the history of the origin and evolution of the concepts Dar al-Islam / Dar al-Harb (both in sunni and shi‘ite traditions) repre-sented in the foundational texts of Islam, medieval Arabic dictionaries, travelogues, and essays on Islamic law (fiqh).
KONTRIBUSI PENGASUHAN ORANGTUA TERHADAP KEMANDIRIAN SISWA SERTA IMPLIKASINYA BAGI PROGRAM BIMBINGAN DAN KONSELING
Authors: Agustine Fadilla , Khairun Deasy Yunika , Nurmala Meilla Dwi
Published: March 2021

Usia remaja merupakan masa transisi menuju kedewasaan. Namun, beberapa siswa SMA belum menunjukkan sikap yang mengarah pada kedewasaan misalnya mencontek dan mudah dipengaruhi oleh teman. Penelitian ini bertujuan untuk mengetahui hubungan dan besaran kontribusi antara pengasuhan orangtua dengan kemandirian siswa. Hasilnya dapat digunakan untuk merancang program bimbingan dan konseling untuk meningkatkan kemandirian siswa. Penelitian ini menggunakan kuantitatif dengan jenis korelasi. Data dikumpulkan dari 96 siswa kelas XI SMAN 7 Kota Serang melalui angket dan dianalisis menggunakan uji korelasi. Hasilnya menunjukkan bahwa terdapat korelasi positif antara pengasuhan orangtua terhadap kemandirian siswa, meskipun tingkat interpretasi hubungannya rendah. Besaran kontribusi pengasuhan orangtua terhadap kemandirian yakni 11%, yang berarti masih ada 89% faktor lain yang berkontribusi terhadap kemandirian siswa namun tidak tercakup dalam penelitian ini. Kata kunci: Pengasuhan orangtua, kemandirian siswa, siswa SMA
PESANTREN LANSIA: TELAAH PADA PENDIDIKAN SPIRITUAL SANTRI LANSIA DI PONDOK SEPUH PAYAMAN MAGELANG
Authors: Agustina Dwi
Published: March 2021

Artikel ini membahas tentang pendidikan spiritual santri lansia di Pondok Sepuh Payaman Magelang. Secara kultural, pendidikan telah dimulai dari lahir hingga meninggal dunia. Usaha sadar akan sebuah pendidikan tidak hanya pada usia dini tetapi sampai pada usia lanjut. Perhatian tersebut ada karena perlunya pegangan lansia akan kebutuhan agama sebagai bekal di akhirat. Metode dalam penelitian ini menggunakan kualitatif studi kasus. Pengumpulan data menggunakan wawancara dan pengamatan. Temuan dalam penelitian menunjukkan bahwa motivasi lansia menjadi santri di pondok sepuh karena keinginan mereka sendiri dan keinginan dari keluarga untuk belajar ilmu agama dan meninggal dalam keadaan husnul khotimah. Kehidupan santri lansia selama di pondok, dihabiskan untuk beribadah secara ritual maupun sosial selama lebih dari 12 jam. Tujuan, metode, dan materi pembelajaran menjadi komponen utama dalam pelaksanaan pendidikan spiritual di pondok sepuh. Tidak ada hukuman dalam membina santri lansia. Namun, sangsi sosial berlaku bagi santri lansia yang tidak mengikuti pembelajaran. Kata kunci: Pendidikan, lansia, pesantren
Evaluasi kinerja pembangunan bidang pendidikan di Kabupaten Ngawi Tahun 2016-2018, Provinsi Jawa Timur
Authors: Sidik Fajar , Firmansyah Firmansyah
Published: March 2021

Problem kemiskinan dihadapi daerah-daerah telah menyebabkan perekonomian daerah kurang berkembang, termasuk daerah Ngawi, provinsi Jawa Timur. Tiga tahun terakhir (Tahun 2016-2018), pemerintah daerah kabupaten Ngawi berhasil menurunkan angka kemiskinan. Meski berhasil menurunkan angka kemiskinan, Ngawi masih dikategorikan sebagai daerah miskin dibanding dengan daerah-daerah yang ada di Provinsi Jawa Timur. Kondisi ini menunjukkan bahwa kinerja pemerintah daerah Kabupaten Ngawi dalam menjalankan program pengentasan kemiskinan perlu dievaluasi. Melalui dimensi pendidikan, kinerja pemerintah daerah Kabupaten Ngawi dicermati untuk menemukan akar persoalan yang dialami penduduk miskin. Penelitian kepustakaan digunakan untuk menilai kinerja pemerintah daerah di bidang pendidikan dari tahun 2016 hingga tahun 2018. Berdasarkan analisis data yang dilakukan, hasil penelitian ini menunjukkan bahwa kinerja pemerintah daerah kabupaten Ngawi dari tahun 2016-2018 belum mampu mencapai target yang direncanakan.
The Effectiveness and Usability of Online, Group-Based Interventions for People With Severe Obesity: Protocol for a Systematic Review
Authors: Milne-Ives Madison , Swancutt Dawn , Burns Lorna , Pinkney Jonathan , Tarrant Mark , Calitri Raff , Chatterjee Arunangsu , Meinert Edward
Published: March 2021

Background

Globally, obesity is a growing crisis. Despite obesity being preventable, over a quarter of the UK adult population is currently considered clinically obese (typically body mass index ≥35 kg/m2). Access to treatment for people with severe obesity is limited by long wait times and local availability. Online and group-based interventions provide means of increasing the accessibility of obesity prevention and treatment services. However, there has been no prior review of the effectiveness of group-based interventions delivered online for people with severe obesity.

Objective

The purpose of this systematic review protocol is to provide an evaluation of the effectiveness and usability of different types of online, group-based interventions for people with severe obesity.

Methods

The Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) and the Population, Intervention, Comparator, Outcome, and Study (PICOS) frameworks were used to structure this review. The review will systematically search 7 databases: MEDLINE, Embase, the Cumulative Index of Nursing and Allied Health Literature, APA PsycNet, Web of Science, CENTRAL, and the ProQuest Dissertations and Theses databases. Two authors (MM-I and LB) will independently screen the titles and abstracts of identified articles, select studies for inclusion based on the eligibility criteria, and extract data into a standardized form. Any disagreements will be discussed and resolved by a third reviewer (EM) if necessary. Risk of bias will be assessed using the Cochrane Collaboration Risk of Bias 2 tool and a descriptive analysis will be used to evaluate effectiveness and usability.

Results

The systematic review has not yet been started. It is expected to be completed and submitted for publication by December 2021.

Conclusions

This systematic review will summarize the effectiveness and usability of online, group-based interventions for people with obesity. It will identify the types of online delivery that have the strongest support to help inform the development of more useful and engaging interventions for people with severe obesity.

Trial Registration

National Institute for Health Research, PROSPERO CRD42021227101; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021227101

International Registered Report Identifier (IRRID)

PRR1-10.2196/26619
Onomastic interferences in Lycia: Greek reinterpretation of Lycian personal names
Authors: Réveilhac Florian
Published: March 2021

As is well known, Lycia, located on the south-western coast of Asia Minor, was a multicultural and polyglossian area, especially during the second half of the Ist millennium B.C. From the 4th century B.C. onwards — that is before Alexander’s conquests — Greek writing and language became more and more predominant in that region, as a language of prestige, to the detriment of Lycian, which is an Anatolian language related to Luwian and Hittite.

Although most of the indigenous personal names persisted in Lycia until the first centuries A.D., as evidenced by their large number found in Greek inscriptions from the Hellenistic and Roman periods, some of them underwent a little transformation in order to look like Greek names. This process, which is common in a context of language contact, consists in adopting a homophonic or phonetically similar name or element of the name, called “cover name” or, in French, “nom d’assonance” (see Dondin-Payre and Raepsaet-Charlier 2001; Coşkun and Zeidler 2005). One famous example of this type of onomastic adaptation from one language to another is the name of the Mede general who invaded Asia Minor, known in the Greek sources as Ἅρπαγος (Harpagos): the underlying Iranian name is derived from the adjective arba- “small, young” (cf. Sanskrit arbha-) with the hypocoristic suffix -ka-, but it has been slightly modified in its Greek adaptation in order to get it closer to the Greek substantive ἁρπαγή (harpagē) “pillaging”, so the enemy conqueror is reduced to a simple plunderer. I intend to present and discuss some Lycian names adapted as cover names in Greek, like Purihimeti ⁓ Πυριβάτης, with a second element -βάτης (-batēs), cf. verb βαίνω (bainō) “to walk”, and well attested in typical Greek personal names (Bechtel 1917: 92). The other names that will be interpreted are Kuprlle/i- ⁓ Κοπριλις (Koprilis), cf. Κοπρύλος (Koprulos), but also Κύβερνις (Kubernis), Mizu- ⁓ Μεσος (Mesos), cf. μέσος (mesos) “middle”, and Xddazada- ⁓ Κτασασας (Ktasadas), cf. Κτᾱσι- / Κτησι- (Ktāsi- / Ktēsi-).
Análise de sensibilidade às componentes do balanço hídrico para suporte a uma melhor gestão de perdas em sistemas de abastecimento de água
Authors:   Núcleo de Engenharia Sanitária, Laboratório Nacional de Engenharia Civil, Lisboa, Loureiro Dália , Mamade Aisha , Silva Maria Almeida , Arregui Francisco , Alegre Helena
Published: March 2021

Apesar da qualidade de serviço assegurada atualmente pelos sistemas de abastecimento de água (SAA) em Portugal, o valor de água não faturada nos sistemas em “baixa” tem-se mantido praticamente constante e com desempenho insatisfatório nos últimos anos. O balanço hídrico constitui um standard para avaliar a água entrada, o consumo faturado e não faturado em SAA. A quantificação fiável das componentes de água não faturada, para identificação dos principais problemas de perdas, constitui uma etapa preliminar crucial para a definição de um plano de gestão de perdas de água e de energia a médio prazo. No entanto, devido ao facto de várias componentes do balanço serem obtidas por estimativa, são necessárias abordagens que permitam o seu cálculo sistemático e uma avaliação da qualidade dos resultados com vista à redução das incertezas e a uma melhor avaliação da dimensão do problema. Este artigo analisa a incerteza das componentes do balanço hídrico, identifica alguns fatores que podem influenciar a qualidade da medição da água entrada e faz uma análise de sensibilidade ao indicador de perdas aparentes num conjunto de 22 entidades gestoras de sistemas de distribuição de água. Despite the high quality of service provided nowadays by drinking water supply systems in Portugal, the value of non-revenue water in drinking water distribution systems (DWDS) has been practically constant and with a poor service level in last years. The water balance is a standard for assessing system input volume, billed consumption and non-revenue water components in DWDS. Reliable quantification of non-revenue water components, for identification of the main problems, is an essential preliminary step in the definition of a plan for water loss and energy management in a medium-term horizon. However, because several components of the water balance are obtained by estimation, approaches are necessary to enable them to be systematically calculated and to evaluate the quality of results to reduce uncertainties and to better assess the water loss problems. This paper analyses the uncertainty associated with water balance components and the results of the apparent loss performance indicator in a set of 22 DWDS to establish reference values.
NOTA TÉCNICA Controlo de afluências indevidas na Águas de Barcelos
Authors:   Águas de Barcelos, Barcelos, Portugal, Sousa Célia , Santos Miguel , Cruz Daniela
Published: March 2021

As afluências indevidas às redes de drenagem de águas residuais têm impactes ambientais, económicos e sociais muito relevantes. Com a consciencialização da dimensão deste problema, a Águas de Barcelos elaborou um Plano de Controlo de Afluências Indevidas 2018-2023 que tem como principais objetivos: i) diminuir os custos diretos das afluências indevidas; ii) diminuir os custos indiretos relacionados com horas de bombagem, custos de energia e custos de manutenção associados à entrada de caudais indevidos; iii) diminuir o risco de incumprimento da legislação nacional e o risco de contaminação dos meios recetores por ocorrência de descargas excedentes e; iv) aumentar a fiabilidade e resiliência da infraestrutura ao longo dos anos. A implementação deste plano permitiu em 2018 a deteção de 451 ligações pluviais ilícitas à rede de drenagem de saneamento, 220 ligações ilícitas de saneamento, 169 infiltrações em infraestruturas e um ilícito industrial com uma descarga mensal de cerca de 10 000 m3 de efluente industrial não faturado. The rainfall-derived infiltration and inflow (RDII) on wastewater drainage systems present relevant environmental, economic and social impacts. With the heightened awareness of the problem, the Águas de Barcelos developed a Rainfall-Derived Infiltration and Inflow Control Plan 2018-2023 with main objectives: i) reduce RDII direct costs; ii) reduce indirect costs with pumping hours, energy and maintenance costs, related to RDII input; iii) reduce the risk of non-compliance with legal requirements and the risk of contamination of the receiving environment by the occurrence of overflows and; iv) increase the infrastructure reliability and resilience over the years. The implementation of this plan enabled, in 2018, the detection of 451 illicit stormwater connections to the wastewater drainage system, 220 illicit domestic wastewater connections, 169 inflows and an illicit industrial connection with 10 000 m3 monthly average discharge.
Computational Fluid Dynamics: Flow Field of an Impeller
Authors: Jasim Yaser A. , Thabet Senan , Thabit Thabit H.
Published: March 2021

This paper aims to develop a centrifugal pump with variable speed controlled by inverter to adjust the flow and the head by the operator and to observe the velocity profile and pressure distribution by using computational fluid dynamic simulation program using Pheonics software. According to the simulation results, the researchers concluded that the pressure increases gradually from impeller inlet to impeller outlet and centrifugal pumps have reasonable price and maintenance as well as high efficiency comparing to the price and been more advanced by coating the inner surfaces with anti-corrosion and smooth material to reduce the friction and raise the efficiency.
Rancang Ulang Proses Bisnis Dengan Metode Business Process Reengineering Pada TLS Cargo
Authors: Waluyo Mutia Nur , Suhendar Endang , Suprapto Hugo Aries
Published: March 2021

TLS Cargo merupakan perusahaan jasa perantara pengiriman barang, baik antar kota ataupun antar pulau. Permasalahan yang terjadi di TLS Cargo yaitu tidak ada koneksi langsung antar divisi sehingga kurangnya monitoring pada pengiriman barang yang menyebabkan customer membutuhkan waktu yang relatif lama untuk mengetahui status dari barang yang dikirim.Tujuan dari penelitian ini adalah memperbaiki proses bisnis pada TLS Cargo untuk mengurangi waste time yang terjadi selama proses bisnis tersebut berlangsung. Metode yang digunakan dalam penelitian ini adalah dengan business proses reengineering yang memperbaiki proses bisnis dengan menerapkan teknologi informasi, sehingga rancang ulang proses bisnis tersebut dapat memperbaikan bisnis dari yang manual menjadi terkomputerisasi melalui sistem. Berdasarkan hasil penelitian yang dilakukan penulis, dapat disimpulkan jika hasil dari perbaikan proses business process reengineering dapat di implementasikan di TLS Cargo dengan input database di dalam sistem Login. Dengan adanya sistem Login ini, admin ataupun user dapat menginput proses pengiriman dan dapat mengirimkan progress data secara realtime. Hasil efisiensi yang diperoleh dari adanya rancang ulang proses bisnis TLS Cargo adalah 86,99% yang menunjukkan peningkatan efisiensi sebesar 30,52% jika dibandingkan dengan sebelum rancang ulang.
Evaluation de la qualité des eaux de surface de la rivière Kadicha
Authors:   Laboratoire des sciences de l’eau et de l’environnement (LSEE), Université libanaise, Tripoli, Liban, Merhabi F. , Amine H. ,   Laboratoire des sciences de l’eau et de l’environnement (LSEE), Université libanaise, Tripoli, Liban, Halwani J. ,   Laboratoire des sciences de l’eau et de l’environnement (LSEE), Université libanaise, Tripoli, Liban
Published: March 2021

La rivière «Kadicha»au nord du Liban est soumise à des pressions urbaines, agricoles et industrielles. Enl’absence de station d’épuration, Les eaux usées sont rejetées directement dans le cours de la rivière. Afin d’évaluer la qualité des eaux de surface de la rivière Kadicha, 12 sites d’échantillonnage, ont été sélectionnésau niveau desquels des prélèvementsponctuels des eaux de surfaceont été effectués sur 2 saisons (humide et sèche). Les paramètres physico-chimiques ont étédéterminés: pH, température, conductivité électrique, TDS (solides totaux dissous) et les MES (matières en suspension). Des analyses bactériologiques en coliformes thermotolérants(CTT) et en streptocoques fécaux (SF) ont été effectuéespar les méthodes classiques de filtration sur membrane.Le suivi des paramètres physico-chimiques indique une variation spatiale influencée par les activités anthropiques exercées. En se basant sur le système d’évaluation dela qualité des eaux littorales(SEQ-Eau), il ressort que les eauxdes 2 bras étudiés de la rivière ontune très bonne qualitéchimique. Cependant, les résultats de l’analyse bactériologique indiquentl’existence d’une contamination fécalequi dépasse les normes pour une utilisation d’eau à des fins récréatives et pour l’irrigation avec des risques sanitaires pour la santé humainesurtout au niveau de la plaine côtièrede la rivière. La comparaison des teneurs en microorganismes dela présente étude avec une étude précédente réalisée en 2006 sur la rivière Kadicha, indique une augmentation en ces teneurs. Ceci pourrait être liéà l’augmentation des activités anthropiques et démographiquesdurant la dernière décade.
Screening Bioactivity of Kersen Fruits (Muntingia calabura L.) as a Sunscreens Candidate
Authors: Nur Syamsu , Nursamsiar Nursamsiar , Aswad Muhammad , Tumigolung Aprilia Ester Eunike , Risfah Yulianti  , Burhan Asril
Published: March 2021

Kersen (Muntingia calabura L) fruits have the potential to be used as an active ingredient in sunscreens because of phenolic and flavonoid content that can absorb UV rays. This study aims to determine the percentage of erythema/pigmentation transmission and SPF value as parameters for sunscreen activity.  Kersen fruits were extracted by maceration using 96% ethanol. The ethanol extract of Kersen Fruits was also fractionated to separate the components of the active compounds based on the polarity level using n-hexane, ethyl acetate, and ethanol as solvents. The test was carried out using the in vitro method by measuring the ability of the material to absorb ultraviolet light at a wavelength of 292.5-372.5 nm. This research was conducted at concentrations of 100, 200, 400, 600, and  800 µg/mL for ethanol, lyophilisate, n-hexane, and ethanol fractions, while the ethyl acetate fraction concentrations are 50, 100, 150, 200, 250 µg/mL. The results showed the best value at the ethyl acetate fraction concentration of 250 µg/mL with % Te of 5.28 and % Tp of 28.65 and the SPF value of 16.54. Based on the % Te and Tp, the ethyl acetate fraction exhibited protection against erythema and pigmentation with the category of extra protection and based on the SPF value with the category of ultra protection.
Interfacial Fracture Toughness Measurement of Welded Babbitt alloy SnSb11Cu6/ 20Steel
Authors: Gao Yuepeng , Wang Janmei , Liu Yuyang
Published: March 2021

The interface fracture toughness of SnSb11Cu6/20steel was measured by
calculating the critical energy release rate and stress phase angle of
the interface crack. A three-point bending test was used to introduce
cracks into the bonding interface, and the cohesion model of the bonding
interface was established through experimental data. Through finite
element analysis of load-deflection curves with and without interface
crack propagation, the crack initiation point is found. Then the energy
calculation model of crack propagation is established, and the critical
energy release rate is obtained using the virtual crack growth
criterion. The calculation results of the stress phase angle show that
the crack propagation is greatly affected by the normal stress after the
babbitt alloy layer fractures. If the strength of the substrate material
is weaker, the crack will continue to expand in the tangent
perpendicular to the crack tip.
Calibration of spectrometric detectors for air kerma rates in environmental monitoring
Authors: Ohera Marcel , Sas Daniel , Sladek Petr
Published: March 2021

The spectrometric systems, especially based on NaI(Tl) and HPGe detectors,
are used for nuclide identification and calculation of their activities
from the ground measurements and air-borne monitoring. The determination of
the air kerma (dose) rates is also very important for environmental
measurements. In such cases, the detectors should be calibrated for air
kerma (dose) rates in nGyh?1 or ?Gyh?1. A simple calibration of NaI(Tl),
HPGe as well as plastic detectors for the low-level air kerma rates is
presented in this contribution. This calibration is based on comparing the
relative absorbed energy rate in detectors (MeVs?1) calculated from spectra
with the air kerma rates calculated by the Monte Carlo simulation and
supplementary to the data from the RSS Reuter&Stokes high pressure ion
chamber. This method also eliminates the conversion from the non-air kerma
rates in crystals to the air kerma rates. Three different types of small
cylindrical detectors were calibrated for the air kerma rates from the
background of 26 nGyh?1 to some tens of ?Gyh?1 in the energy range to the
maximum of 3 MeV. The results of calibrations of the 3" x 3" NaI(Tl), HPGe
detector and a small plastic detector (made of polystyrene) including
soxme examples of environmental measurements are presented.
Adli Bilişim ve Dijital Delillerin Windows İşletim Sistemi Üzerinde İncelenmesi
Authors: ÖNEL Bünyamin , IRMAK Erdal
Published: March 2021

İnternet ve bilişim sistemleri üzerinde işlenen suçları tespit etmek amacıyla gerçekleştirilen adli bilişim incelemelerinin önemi, her geçen gün daha iyi anlaşılmaktadır. Bu minvalde suç ve suçlunun tespiti konusunda hukuka uygun dijital delillerin elde edilmesinin önemi çok büyüktür. Adli bilişim incelemelerinde, birçok farklı yöntem ile dijital deliller elde edilebilir. Özellikle bilişim sistemleri üzerinde kullanılan işletim sistemleri buna çok iyi bir örnektir. Küresel ölçekte olduğu gibi ülkemizde de gerek kişisel kullanımlarda gerekse kurumsal şirketlerde Windows işletim sistemi yaygın olarak kullanılmaktadır. Sanal dünya üzerinde işlenen suçların ve mağduriyetlerin çoğunluğu bu sistem üzerinde yaşanmaktadır. Bu nedenle çalışmada, Windows işletim sistemi üzerinde adli bilişim çalışması yapma gereksinimi duyulmuştur. Adli bilişim alanındaki güncel çalışmalar literatüre daha çok kavramsal ve hukuksal düzenleme olarak katkıda bulunmaktadır. Bu çalışmada ise metodolojik ve teknik analizler birlikte kullanılarak Windows PowerShell ve üçüncü parti yazılımlarla adli bilişim çalışması yapılması amaçlanmıştır. Böylece sistem bileşenleri üzerindeki dijital deliller, metedolojik ve teknik yöntemlerle analiz edilip, elde edilen sonuçlar görsel verilerle ortaya konulmuştur.
ORIGEM FITOGEOGRÁFICA, ESTRUTURA FILOGENÉTICA E SÍNDROMES DE DISPERSÃO DE ESPÉCIES ARBÓREAS EM FLORESTA OMBRÓFILA MISTA NO PLANALTO CATARINENSE
Authors: Küster Larissa Cardoso , Higuchi Pedro , Da Silva Ana Carolina , Ansolin Roni Djeison , Bento Marco Antônio , Buzzi Júnior Fernando , Ferreira Tiago de Souza
Published: March 2021

Os remanescentes florestais desempenham importantes funções ecossistêmicas, além de possuírem elevada diversidade residual. Um maior conhecimento ecológico destas áreas é fundamental para a sua conservação. Por isso, este estudo objetivou avaliar a fitogeografia, a estrutura filogenética e as síndromes de dispersão de espécies arbóreas de um fragmento de Floresta Ombrófila Mista no Planalto Catarinense, Brasil. As espécies amostradas no fragmento foram classificadas de acordo com sua origem fitogeográfica e síndrome de dispersão. A estruturação filogenética foi avaliada por meio dos valores de “Mean pairwise distance” (MPD) e de “Net Relatedness Index” (NRI). O gradiente ambiental foi analisado por meio de uma Análise de Componentes Principais. A influência do ambiente sobre a estruturação filogenética foi verificada por meio de um modelo linear pelo método dos Mínimos Quadrados Generalizados (GLS). As espécies tiveram a predominância de ampla distribuição (62,3%) e zoocoria (79,7%). A comunidade apresentou um padrão filogenético aleatório, sendo que o mesmo, em escala local, foi influenciado pela fertilidade do solo. Estes resultados reforçam a ideia de que o perfil florístico de áreas de floresta com araucária foi fortemente determinado por eventos históricos de migração das espécies a partir de diferentes origens, sendo que a fauna desempenhou um importante papel neste processo