bluuebunny/crossref_metadata_2025 huggingface dataset:
Once-Weekly Semaglutide for Weight Management: A Clinical Review
Authors: Fornes Abby , Huff Jamie , Pritchard Roger Iain , Godfrey Miranda
Published: May 2022

Objective: To review the efficacy, safety, and role of the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide for chronic weight management. Data Sources: A literature search of PubMed/MEDLINE and Google Scholar was performed using the search terms: semaglutide 2.4, weight, and obesity. Ongoing studies of semaglutide were identified utilizing clinicaltrials.gov. Study Selection and Data Extraction: All English-language articles evaluating the efficacy and safety of semaglutide 2.4 mg for weight management in humans were included. Data Synthesis: Once-weekly injectable semaglutide 2.4 mg is indicated as an adjunct to a reduced-calorie diet and increased exercise for chronic weight management in adults with a body mass index (BMI) ≥30 kg/m2 or ≥27 kg/m2 with at least one weight-related comorbidity, such as hypertension, type 2 diabetes mellitus, or dyslipidemia. Semaglutide 2.4 mg has consistently demonstrated clinically significant weight loss across all phase 3 STEP (semaglutide treatment effect in people with obesity) trials, and long-term efficacy and safety have been confirmed for up to 2 years. Gastrointestinal side effects were the most frequently reported side effects, including nausea, vomiting, constipation, and diarrhea. Safety data for semaglutide 2.4 mg were consistent with that reported previously for the GLP-1 receptor agonist class. Conclusions: Semaglutide 2.4 mg is a highly efficacious agent for weight management, with a safety profile similar to that of other GLP-1 receptor agonists. It is a feasible option for chronic weight management, with data for up to 2 years. It is currently the only once-weekly weight loss medication, although cost may limit its utilization.
Bayesian parameter estimation of duration-based variables used in post-earthquake building recovery modeling
Authors: Omoya Morolake , Burton Henry , Baroud Hiba
Published: May 2022

A Bayesian parameter estimation methodology for updating the distributions of the duration-based variables used in post-earthquake building recovery modeling is presented. The distributions of the recovery-related parameters specified in the resilience-based earthquake design initiative (REDi) and HAZUS are used as the basis of the priors. A data set of observed building damage and recovery following the 2014 South Napa earthquake is assembled and used to illustrate the proposed methodology. The recovery data set includes the permit acquisition and repair time for over 800 buildings affected by the earthquake. With this data, the conjugate prior (CP) and Markov Chain Monte Carlo (MCMC) methods are implemented to update the probability distribution parameters for the duration-based recovery variables. While the CP approach is easier to implement because it offers an analytical solution, the MCMC provides more flexibility in terms of the types of prior and sampling distributions that can be accommodated. Moreover, the results from a comparative implementation on the Napa data set shows that the MCMC method provides a reasonable approximation of the posterior marginal distribution of the duration-based recovery variables relative to the CP analytical solution.
Using mobility status as a frailty indicator to improve the accuracy of a computerised five-level triage system among older patients in the emergency department
Authors: Chien Cheng-Yu , Chaou Chung-Hsien , Yeh Chung-Cheng , Hsu Kuang-Hung , Gao Shi-Ying , Ng Chip-Jin
Published: May 2022

Background

Owing to societal ageing, the number of older individuals visiting emergency departments (EDs) has increased in recent years. For this patient population, accurate triage systems are required. This retrospective cohort study assessed the accuracy of a computerised five-level triage system, the Taiwan Triage and Acuity System (TTAS), by determining its ability to predict in-hospital mortality in older adult patients and compare it with the corresponding rate in younger adult patients presenting to EDs. The association between frailty, which the current triage system does not consider, was also investigated.

Methods

The medical records of adult patients admitted to a single ED between 2016 and 2017 were reviewed. Data collected included information on demographics, triage level, frailty status, in-hospital mortality, and medical resource utilisation. The patients were divided into four age groups: two older adult groups (older: 65–84 years and very old: ≥85 years) and two younger adult groups (young: 18–39 and middle-aged: 40–64 years).

Results

Our study included 265,219 ED adult patients, of whom 64,104 and 16,009 were in the older and very old groups, respectively. The in-hospital mortality rate at each triage level increased with age. The ability of the TTAS to predict in-hospital mortality decreased with age (area under the receiver operating characteristic curve [AUROC]: young: 0.86; middle-aged, 0.84; and older and very old: 0.79). Frailty was associated with in-hospital mortality (odds ratio, 2.20; 95% confidence interval, 2.03–2.38). Adding mobility status as a frailty indicator to TTAS only slightly improved its ability to predict in-hospital mortality (AUROC: 0.74–0.77) in patients ≥65 years of age.

Conclusions

The ability of the current triage system to predict in-hospital mortality decreases with age. Although frailty as mobility was associated with in-hospital mortality, its addition to the TTAS only slightly improved the accuracy with which in-hospital mortality in older patients presenting to EDs was predicted.
Coverage and factors associated with completion of continuum of care for maternal health in sub-Saharan Africa: a multicountry analysis
Authors: Alem Adugnaw Zeleke , Shitu Kegnie , Alamneh Tesfa Sewunet
Published: May 2022

Background

Many maternal and neonatal deaths are largely preventable by expanding the continuum of care (at least four antenatal visits, skilled birth attendance and postnatal care). Even though ensuring the Continuum of Care (CoC) has advantages over separate services, evidence from the globe suggests that completion of the CoC for maternal health is very low. From our search of the literature, there is limited evidence on the completion of the entire CoC and its associated factors in sub-Saharan Africa (sSA). Therefore, this study aimed to assess coverage and associated factors of completion of the CoC for maternal health in sSA.

Methods

Data for the study were drawn from a recent nationally representative survey of 32 Demographic and Health Surveys (DHS). A total weighted sample of 225,135 women of reproductive-age, who gave birth in the two preceding years were included. Due to the hierarchical nature of DHS data, a multilevel logistic regression model was applied to investigate individual and community-level factors that may influence completion of CoC. Adjusted Odds Ratios (aORs) with 95% Confidence Interval (CI) were reported and variables with 95% CI not including 1 were considered as significant factors of the completion of CoC.

Results

Only, 56,172 (25.0%; 95% CI, 20.5%, 29.4%) of the women in sSA utilized the CoC for maternal health which varied from 11,908 (17.9.0%) in East Africa to 7,418 (51.5% in Southern Africa. Factors associated with higher odds of CoC were women aged 24–34 years (aOR 1.22, 95% CI: 1.17, 1.25), aged ≥ 35 years (aOR 1.40, 95% CI: 1.35, 1.47), attending primary education (aOR 1.44, 95% CI: 1.41, 1.49), secondary education (aOR 1.95, 95% CI: 1.89, 2.03), higher education (aOR 2.15, 95% CI: 2.01, 2.25), having mass media exposure (aOR 1.35, 95% CI: 1.28, 1.39), women from female-headed households (aOR 1.18, 95% CI: 1.15, 1.21) and women from communities with high maternal education (aOR 1.12, 95% CI: 1.09, 1.16). However, perceiving distance from the health facility as a big problem (aOR 0.88, 95% CI: 0.85, 0.91), residing in rural areas (aOR 0.78, 95% CI: 0.75, 0.81), delayed ANC initiation (aOR 0.43, 95% CI: 0.41, 0.47) and unintended pregnancy (aOR 0.87, 95% CI: 0.84, 0.91) were associated with lower odds of CoC.

Conclusion

This study showed a low proportion of women, who utilized the CoC in sSA. Both individual and community-level factors were associated with CoC completion rates among women in sSA. Therefore, policymakers in sSA must consider both individual and community-level factors and undertake multi-sectorial approaches to address barriers of CoC at different levels.
Could radiofrequency echographic multispectrometry (REMS) overcome the overestimation in BMD by dual-energy X-ray absorptiometry (DXA) at the lumbar spine?
Authors: Caffarelli Carla , Tomai Pitinca Maria Dea , Al Refaie Antonella , De Vita Michela , Catapano Simone , Gonnelli Stefano
Published: May 2022

Background

Osteoarthritis (OA) and vertebral fractures at the lumbar spine lead to an overestimation of bone mineral density (BMD). Recently, a new approach for osteoporosis diagnosis, defined as radiofrequency echographic multi-spectrometry (REMS), represents an innovative diagnostic tool that seems to be able to investigate bone quality and provide an estimation of fracture risk independent of BMD.

The aim of this paper was to evaluate whether the use of REMS technology can favor the diagnosis of osteoporosis in subjects with an apparent increase in BMD.

Methods

In a cohort of 159 postmenopausal (66.2 ± 11.6 yrs) women with overestimated BMD by DXA at the lumbar spine, we performed an echographic scan with the REMS technique.

Results

The mean values of BMD at different skeletal sites obtained by the DXA and REMS techniques showed that the BMD T-scores by REMS were significantly lower than those obtained by the DXA technique both at the lumbar spine (p < 0.01) and at all femoral subregions (p < 0.05). In OA subjects, the percentage of women classified as “osteoporotic” on the basis of BMD by REMS was markedly higher with respect to those classified by DXA (35.1% vs 9.3%, respectively). Similarly, the REMS allows a greater number of fractured patients to be classified as osteoporotic than DXA (58.7% vs 23.3%, respectively).

Conclusions

REMS technology by the analysis of native raw unfiltered ultrasound signals appears to be able to overcome the most common artifacts, such as OA and vertebral fracture of the lumbar spine, which affect the value of BMD by DXA.
Prevalence of post-COVID-19 in patients with fibromyalgia: a comparative study with other inflammatory and autoimmune rheumatic diseases
Authors: Rivera Javier , Rodríguez Tamara , Pallarés Marta , Castrejón Isabel , González Teresa , Vallejo-Slocker Laura , Molina-Collada Juan , Montero Fernando , Arias Anna , Vallejo Miguel A. , Alvaro-Gracia Jose M. , Collado Antonio
Published: May 2022

Objectives

To determine the prevalence and characteristics of post-COVID-19 (PC) in fibromyalgia (FM) patients.

Methods

Retrospective, multi-centric, observational study, comparing a group of FM patients (FM group) with another group of patients with other rheumatic diseases (RD group). COVID-19 diagnosis was established by positive polymerase chain reaction or antigen during acute infection or by positive antibodies thereafter. We considered PC diagnosis when symptoms remain after COVID-19. We collected the principal characteristics of COVID-19, the severity of fatigue, waking unrefreshed and cognitive impairment, and persistent symptoms. The American College of Rheumatology (ACR) criteria and the Combined Index of Severity in Fibromyalgia (ICAF) were collected in the FM group.

Results

RD group (n = 56) had more pneumonia (p = 0.001) and hospital admissions (p = 0.002), but the FM group (n = 78) had a higher number of symptoms (p = 0.002). The percentage of patients with PC was similar between groups (FM group 79.5%; RD group 66.1%, p = 0.081). FM group had more PC symptoms (p = 0.001), more impairment after COVID-19 (p = 0.002) and higher severity of fatigue, waking unrefreshed and cognitive impairment (p <  0.0001). Only loss of smell was more frequent in the FM group (p = 0.005). The FM group with PC (n = 29) showed more severity of the Combined Index of Severity in Fibromyalgia (ICAF) total score and physical factor after COVID-19, while emotional, coping factors and the ACR criteria did not change.

Conclusions

The prevalence of PC in FM patients is similar to RD patients. In FM patients, the presence of PC does not appear to impact the severity of FM.
Risk factors of fracture following curettage for bone giant cell tumors of the extremities
Authors: Tsukamoto Shinji , Mavrogenis Andreas F. , Akahane Manabu , Honoki Kanya , Kido Akira , Tanaka Yasuhito , Donati Davide Maria , Errani Costantino
Published: May 2022

Background

Following curettage of giant cell tumor of bone (GCTB), it is common to fill the cavity with polymethylmethacrylate (PMMA) bone cement, bone allograft, or artificial bone to maintain bone strength; however, there is a 2–14% risk of postoperative fractures. We conducted this retrospective study to clarify the risk factors for fractures after curettage for GCTB of the extremities.

Methods

This study included 284 patients with GCTBs of the extremities who underwent curettage at our institutions between 1980 and 2018 after excluding patients whose cavities were not filled with anything or who had additional plate fixation. The tumor cavity was filled with PMMA bone cement alone (n = 124), PMMA bone cement and bone allograft (n = 81), bone allograft alone (n = 63), or hydroxyapatite graft alone (n = 16).

Results

Fractures after curettage occurred in 10 (3.5%) patients, and the median time from the curettage to fracture was 3.5 months (interquartile range [IQR], 1.8–8.3 months). The median postoperative follow-up period was 86.5 months (IQR, 50.3–118.8 months). On univariate analysis, patients who had GCTB of the proximal or distal femur (1-year fracture-free survival, 92.5%; 95% confidence interval [CI]: 85.8–96.2) presented a higher risk for postoperative fracture than those who had GCTB at another site (100%; p = 0.0005). Patients with a pathological fracture at presentation (1-year fracture-free survival, 88.2%; 95% CI: 63.2–97.0) presented a higher risk for postoperative fracture than those without a pathological fracture at presentation (97.8%; 95% CI: 95.1–99.0; p = 0.048). Patients who received bone grafting (1-year fracture-free survival, 99.4%; 95% CI: 95.7–99.9) had a lower risk of postoperative fracture than those who did not receive bone grafting (94.4%; 95% CI: 88.7–97.3; p = 0.003).

Conclusions

For GCTBs of the femur, especially those with pathological fracture at presentation, bone grafting after curettage is recommended to reduce the risk of postoperative fracture. Additional plate fixation should be considered when curettage and cement filling without bone grafting are performed in patients with GCTB of the femur. This should be specially performed for those patients with a pathological fracture at presentation.
Nanoliposomes containing limonene and limonene-rich essential oils as novel larvicides against malaria and filariasis mosquito vectors
Authors: Sanei-Dehkordi Alireza , Moemenbellah-Fard Mohammad Djaefar , Saffari Mostafa , Zarenezhad Elham , Osanloo Mahmoud
Published: May 2022

Background

Mosquito-borne diseases such as malaria and encephalitis are still the cause of several hundred thousand deaths annually. The excessive use of chemical insecticides for transmission control has led to environmental pollution and widespread resistance in mosquitoes. Botanical insecticides' efficacies improvement has thus received considerable attention recently.

Methods

The larvicidal effects of three essential oils from the Citrus family and limonene (their major ingredient) were first investigated against malaria and filariasis mosquito vectors. An attempt was then made to improve their efficacies by preparing nanoliposomes containing each of them.

Results

The larvicidal effect of nanoformulated forms was more effective than non-formulated states. Nanoliposomes containing Citrus aurantium essential oil with a particle size of 52 ± 4 nm showed the best larvicidal activity (LC50 and LC90 values) against Anopheles stephensi (6.63 and 12.29 µg/mL) and Culex quinquefasciatus (4.9 and 16.4 µg/mL).

Conclusion

Due to the green constituents and high efficacy of nanoliposomes containing C. aurantium essential oil, it could be considered for further investigation against other mosquitoes’ populations and field trials.
Is YouTube a reliable source of health-related information? A systematic review
Authors: Osman Wael , Mohamed Fatma , Elhassan Mohamed , Shoufan Abdulhadi
Published: May 2022

Background

YouTube is a valuable source of health-related educational material which can have a profound impact on people’s behaviors and decisions. However, YouTube contains a wide variety of unverified content that may promote unhealthy behaviors and activities. We aim in this systematic review to provide insight into the published literature concerning the quality of health information and educational videos found on YouTube.

Methods

We searched Google Scholar, Medline (through PubMed), EMBASE, Scopus, Direct Science, Web of Science, and ProQuest databases to find all papers on the analysis of medical and health-related content published in English up to August 2020. Based on eligibility criteria, 202 papers were included in our study. We reviewed every article and extracted relevant data such as the number of videos and assessors, the number and type of quality categories, and the recommendations made by the authors. The extracted data from the papers were aggregated using different methods to compile the results.

Results

The total number of videos assessed in the selected articles is 22,300 (median = 94, interquartile range = 50.5–133). The videos were evaluated by one or multiple assessors (median = 2, interquartile range = 1–3). The video quality was assessed by scoring, categorization, or based on creators’ bias. Researchers commonly employed scoring systems that are either standardized (e.g., GQS, DISCERN, and JAMA) or based upon the guidelines and recommendations of professional associations. Results from the aggregation of scoring or categorization data indicate that health-related content on YouTube is of average to below-average quality. The compiled results from bias-based classification show that only 32% of the videos appear neutral toward the health content. Furthermore, the majority of the studies confirmed either negative or no correlation between the quality and popularity of the assessed videos.

Conclusions

YouTube is not a reliable source of medical and health-related information. YouTube’s popularity-driven metrics such as the number of views and likes should not be considered quality indicators. YouTube should improve its ranking and recommender system to promote higher-quality content. One way is to consider expert reviews of medical and health-related videos and to include their assessment data in the ranking algorithm.
Design principles, manufacturing and evaluation techniques of custom dynamic ankle‐foot orthoses: a review study
Authors: Rogati Giulia , Caravaggi Paolo , Leardini Alberto
Published: May 2022

Ankle‐Foot Orthoses (AFO) can be prescribed to allow drop‐foot patients to restore a quasi‐normal gait pattern. Standard off‐the‐shelf AFOs are cost‐effective solutions to treat most patients with foot and ankle weakness, but these devices have several limitations, especially in terms of comfort. Therefore, custom AFOs are increasingly adopted to address drop‐foot when standard solutions are not adequate. While the solid ones are the most common type of AFO, providing full stability and strong resistance to ankle plantarflexion, passive dynamic AFOs (PD‐AFOs) represent the ideal solution for patients with less severe ankle weakness. PD‐AFOs have a flexible calf shell, which can bend during the stance phase of walking and absorb energy that can be released to support the limb in the push‐off phase. The aim of this review is to assess the state‐of‐the‐art and identify the current limitations of PD‐AFOs. An extensive literature review was performed in Google Scholar to identify all studies on custom PD‐AFOs. Only those papers reporting on custom PD‐AFOs were included in the review. Non peer‐reviewed papers, abstract shorter than three pages, lecture notes and thesis dissertations were excluded from the analysis. Particular attention was given to the customization principles and the mechanical and functional tests. For each topic, the main results from all relevant papers are reported and summarized herein. There were 75 papers that corresponded to the search criteria. These were grouped according to the following macro‐topics: 16 focusing on scanning technologies and geometry acquisition; 14 on customization criteria; 19 on production techniques; 16 on mechanical testing, and 33 on functional testing. According to the present review, design and production of custom PD‐AFOs are becoming increasingly feasible due to advancements in 3D scanning techniques and additive manufacturing. In general, custom PD‐AFOs were shown to provide better comfort and improved spatio‐temporal parameters with respect to standard solutions. However, no customization principle to adapt PD‐AFO stiffness to the patient's degree of ankle impairment or mechanical/functional demand has thus far been proposed.
Intron retention coupled with nonsense-mediated decay is involved in cellulase biosynthesis in cellulolytic fungi
Authors: Gao Yichen , Pang Ai-Ping , Ma Leyao , Wang Haiyan , Durrani Samran , Li Bingzhi , Wu Fu-Gen , Lin Fengming
Published: May 2022

Background

Knowledge on regulatory networks associated with cellulase biosynthesis is prerequisite for exploitation of such regulatory systems in enhancing cellulase production with low cost. The biological functions of intron retention (IR) and nonsense-mediated mRNA decay (NMD) in filamentous fungi is lack of study, let alone their roles in cellulase biosynthesis.

Results

We found that major cellulase genes (cel7a, cel7b, and cel3a) exhibited concomitant decrease in IR rates and increase in their gene expression in T. reesei under cellulase-producing condition (cellulose and lactose) that was accompanied with a more active NMD pathway, as compared to cellulase non-producing condition (glucose). In the presence of the NMD pathway inhibitor that successfully repressed the NMD pathway, the mRNA levels of cellulase genes were sharply down-regulated, but the rates of IR in these genes were significantly up-regulated. Consistently, the cellulase activities were severely inhibited. In addition, the NMD pathway inhibitor caused the downregulated mRNA levels of two important genes of the target of rapamycin (TOR) pathway, trfkbp12 and trTOR1. The absence of gene trfkbp12 made the cellulase production in T. reesei more sensitive to the NMD pathway inhibitor.

Conclusions

All these findings suggest that the IR of cellulase genes regulates their own gene expression by coupling with the NMD pathway, which might involve the TOR pathway. Our results provide better understanding on intron retention, the NMD pathway, and cellulase production mechanism in filamentous fungi.
Trinity review: integrating Registered Reports with research ethics and funding reviews
Authors: Mori Yuki , Takashima Kaito , Ueda Kohei , Sasaki Kyoshiro , Yamada Yuki
Published: May 2022

One major source of exhaustion for researchers is the redundant paperwork of three different documents—research papers, ethics review applications, and research grant applications—for the same research plan. This is a wasteful and redundant process for researchers, and it has a more direct impact on the career development of early-career researchers. Here, we propose a trinity review system based on Registered Reports that integrates scientific, ethics, and research funding reviews. In our proposed trinity review system, scientific and ethics reviews are undertaken concurrently for a research protocol before running the study. After the protocol is approved in principle through these review processes, a funding review will take place, and the researchers will begin their research. Following the experiments or surveys, the scientific review will be conducted on a completed version of the paper again, including the results and discussions (i.e., the full paper), and the full paper will be published once it has passed the second review. This paper provides the brief process of the trinity review system and discusses the need for and benefits of the proposed system. Although the trinity review system only applies to a few appropriate disciplines, it helps improve reproducibility and integrity.
Genomic supremacy: the harm of conflating genetic ancestry and race
Authors: Cerdeña Jessica P. , Grubbs Vanessa , Non Amy L.
Published: May 2022

Background

Recent studies have reignited the tinderbox of debate surrounding the use of race and ancestry in medicine. These controversial studies have argued for a strong correlation between genetic ancestry and race, justifying continued use of genetic ancestry measures in studies of disease. These studies contend that increased use of continental ancestry estimates can inform clinical risk assessments and management. Further, recent studies of racial corrections used in clinical algorithms, such as those used to estimate 'normal' lung function, also advocate for use of genetic ancestry in place of race for refining risk algorithms.

Main body

These positions are misleading, harmful, and reflect superficial interpretations of population genetics. In this Perspective, we argue that continental genetic ancestry, often proxied by race, serves as a poor indicator of disease risk, and reinforces racialized inequities.

Conclusion

Instead, we endorse that racial disparities in disease should be investigated by rigorous measures of structural racism alongside careful measures of genetic factors in relevant disease pathways, rather than relying on genetic ancestry or race as a crude proxy for disease-causing alleles.
Concept development of an on-chip PET system
Authors: Clement Christoph , Birindelli Gabriele , Pizzichemi Marco , Pagano Fiammetta , Kruithof-De Julio Marianna , Ziegler Sibylle , Rominger Axel , Auffray Etiennette , Shi Kuangyu
Published: May 2022

Background

Organs-on-Chips (OOCs), microdevices mimicking in vivo organs, find growing applications in disease modeling and drug discovery. With the increasing number of uses comes a strong demand for imaging capabilities of OOCs as monitoring physiologic processes within OOCs is vital for the continuous improvement of this technology. Positron Emission Tomography (PET) would be ideal for OOC imaging, however, current PET systems are insufficient for this task due to their inadequate spatial resolution. In this work, we propose the concept of an On-Chip PET system capable of imaging OOCs and optimize its design using a Monte Carlo Simulation (MCS).

Material and methods

The proposed system consists of four detectors arranged around the OOC device. Each detector is made of two monolithic LYSO crystals and covered with Silicon photomultipliers (SiPMs) on multiple surfaces. We use a Convolutional Neural Network (CNN) trained with data from a MCS to predict the first gamma-ray interaction position inside the detector from the light patterns that are recorded by the SiPMs on the detector’s surfaces.

Results

The CNN achieves a mean average prediction error of 0.80 mm in the best configuration. The proposed system achieves a sensitivity of 34.81% for 13 mm thick crystals and does not show a prediction degradation near the boundaries of the detector. We use the trained network to reconstruct an image of a grid of 21 point sources spread across the field-of-view and obtain a mean spatial resolution of 0.55 mm. We show that 25,000 Line of Responses (LORs) are needed to reconstruct a realistic OOC phantom with adequate image quality.

Conclusions

We demonstrate that it is possible to achieve a spatial resolution of almost 0.5 mm in a PET system made of multiple monolithic LYSO crystals by directly predicting the scintillation position from light patterns created with SiPMs. We observe that a thinner crystal performs better than a thicker one, that increasing the SiPM size from 3 mm to 6 mm only slightly decreases the prediction performance, and that certain surfaces encode significantly more information for the scintillation-point prediction than others.
Snacking pattern of college students in Saudi Arabia: a cross-sectional study
Authors: Shatwan Israa M. , Aljefree Najlaa M. , Almoraie Noha M.
Published: May 2022

Background

Although unhealthy snack foods are commonly consumed by college students, snacking patterns among college students have not been comprehensively examined in Saudi Arabia. In our study, we aimed to investigate snacking patterns among Saudi college students and to assess sociodemographic data that affect adherence to these snacking patterns.

Methods

Between January 2021 and March 2021 in Jeddah, Saudi Arabia, an online survey was conducted with 662 college students from a Saudi university. The survey included sociodemographic questions and a short food frequency questionnaire (FFQ) regarding the consumption of common snack foods. Snacking patterns were generated from the FFQ using the factor analysis method.

Results

Factor analyses generated seven snacking patterns, which explained 64.5% of the variance in snacking. Students in their early academic years (1–3 years) had a higher score for the convenience snack and fast-food pattern (0.22 ± 0.48 and 0.31 ± 0.52, respectively) than senior students (4–6 years) (P = 0.03 and 0.04, respectively). Healthy snacks patterns were higher among students at higher income levels (P = 0.006) and active students (P < 0.001) than among students at low- or mid-income levels and inactive students. Higher adherence to the beverages pattern was observed among male students (P = 0.03), active students (P = 0.01), and students with obesity than their counterparts (P = 0.02). The dairy products pattern was higher among male students (P = 0.04), students at higher income levels (P = 0.04), and students with obesity (P = 0.03) than their counterparts.

Conclusions

Most snacking patterns identified among the study participants were considered unhealthy. Adherence to healthy snacks is influenced by physical activity and family income. These findings may be helpful in the future for developing adequate nutrition education programs that promote health by adhering to healthy snack choices in this critical age group. Further studies are needed to confirm these findings and to investigate snacking patterns among other age groups in Saudi Arabia.
Digital patient-reported outcomes in inflammatory bowel disease routine clinical practice: the clinician perspective
Authors: Nielsen Amalie Søgaard , Appel Charlotte W. , Larsen Birgit Furstrand , Hanna Lisa , Kayser Lars
Published: May 2022

Background

Use of digital health services, such as digital patient-reported outcomes, depends on many different human factors as well as digital design solutions. One factor is clinicians’ attitude towards the system, their reasoning behind the using system and their perceptions of patients’ ability to engage with digital health systems. This study aimed to explore hospital clinicians’ attitudes towards digital patient-reported outcomes used in the routine care and treatment of inflammatory bowel disease, and to explore the potential role of clinicians’ attitudes in influencing patients’ use of digital patient-reported outcomes.

Results

Twelve clinicians using digital patient-reported outcome assessments in the care of inflammatory bowel disease were interviewed about their experiences of, and perspectives on, using this service. Most participants supported the use of digital patient-reported outcome assessments in the care of most patients. Participants reported that most patients found the digital solution easy to use. They perceived digital patient-reported outcomes to have three main purposes: prioritising resources; improving patients’ quality of life; and improving quality of care. The patient-clinician relationship was of great importance to participants. Participants varied in their intention to use digital PRO, as some viewed the system as a positive but optional add-on for patients, whilst others intended to use the system with all eligible patients.

Conclusion

Clinicians’ general support of using digital patient-reported outcomes might facilitate their use among patients with inflammatory bowel disease. The participants saw benefits in doing so for patients, clinicians and the wider health service. Clinicians’ attitudes towards the use of digital PRO in the care of their patients may influence patients’ uptake of health service.
Impact of reticulin stain in clinical outcome of Immune Thrombocytopenic Purpura (ITP): a pathologist perspective
Authors: Kanda Rafael Guimarães , Niero-Melo Lígia , Domingues Maria Aparecida Custódio , Oliveira Cristiano Claudino
Published: May 2022

Background

This study evaluated histopathological characteristics of bone marrow (BM) of patients with immune thrombocytopenic purpura (ITP) and sought to find possible associations among them and clinical aspects.

Method

A retrospective study was carried out with 120 patients using BM clot and BM biopsy samples, including morphological (cytological and histological) re-evaluation, reticulin and hemosiderin analysis, and clinical outcome review of medical records. Immunohistochemistry (CD34 and CD117) was applied in a group of patients with increased reticulin, with the objective of exclusion Myelodysplastic syndrome cases

Results

Megakaryocytic hyperplasia was observed in 109 (90.8%) patients and increased reticulin was diagnosed in nine patients, five of them with a clinically unfavorable outcome (p = 0.042). The increase in reticulin graduation was associated with a higher risk of an unfavorable outcome.

Conclusion

Increased reticulin degree in BM of patients with ITP is associated with an unfavorable outcome in this study. It is rarely explored in the literature and may provide information that contributes to understanding the patient's outcomes.
Volumetric breast density evaluation using fully automated Volpara software, its comparison with BIRADS density types and correlation with the risk of malignancy
Authors: Singh Neha , Joshi Pranjali , Singh Deepak Kumar , Narayan Shamarendra , Gupta Anurag
Published: May 2022

Background

Mammography is currently the modality of choice for mass screening of breast cancer, although its sensitivity is low in dense breasts. Besides, higher breast density has been identified as independent risk factor so it has been conceptualized that women with dense breasts should be encouraged for supplemental screening. In this study, we aimed to estimate the distribution of volumetric breast density using fully automated Volpara software and to analyze the level of agreement between volumetric density grades and Breast Imaging Reporting and Data System (BI-RADS) density grades. We also aim to estimate the distribution of breast cancer in different VDG and to find a correlation between VDG and risk of malignancy.

Results

VDG-c was most common followed by VDG-b and BIRADS grade B was commonest followed by grade C. The density distribution was found inversely related to the age. Level of agreement between VDG and BIRADS grades was moderate (κ = 0.5890). Statistically significant correlation was noted between VDG-c and d for risk of malignancy (p < 0.001).

Conclusion

Difficulties associated with the use of BI-RADS density categories may be avoided if assessed using a fully automated volumetric method. High VDG can be considered as independent risk factor for malignancy. Thus, awareness of a woman’s breast density might be useful in determining the frequency and imaging modality for screening.
Perioperative Brain Health in the Older Adult: A Patient Safety Imperative
Authors: Vacas Susana , Canales Cecilia , Deiner Stacie G. , Cole Daniel J.
Published: May 2022

While people 65 years of age and older represent 16% of the population in the United States, they account for >40% of surgical procedures performed each year. Maintaining brain health after anesthesia and surgery is not only important to our patients, but it is also an increasingly important patient safety imperative for the specialty of anesthesiology. Aging is a complex process that diminishes the reserve of every organ system and often results in a patient who is vulnerable to the stress of surgery. The brain is no exception, and many older patients present with preoperative cognitive impairment that is undiagnosed. As we age, a number of changes occur in the human brain, resulting in a patient who is less resilient to perioperative stress, making older adults more susceptible to the phenotypic expression of perioperative neurocognitive disorders. This review summarizes the current scientific and clinical understanding of perioperative neurocognitive disorders and recommends patient-centered, age-focused interventions that can better mitigate risk, prevent harm, and improve outcomes for our patients. Finally, it discusses the emerging topic of sleep and cognitive health and other future frontiers of scientific inquiry that might inform clinical best practices.
Systematic Analysis of Publication Bias in Neurosurgery Meta-Analyses
Authors: Phua Qi Sheng , Lu Lucy , Harding Marguerite , Poonnoose Santosh Isaac , Jukes Alistair , To Minh-Son
Published: May 2022

BACKGROUND:

Statistically significant positive results are more likely to be published than negative or insignificant outcomes. This phenomenon, also termed publication bias, can skew the interpretation of meta-analyses. The widespread presence of publication bias in the biomedical literature has led to the development of various statistical approaches, such as the visual inspection of funnel plots, Begg test, and Egger test, to assess and account for it.

OBJECTIVE:

To determine how well publication bias is assessed for in meta-analyses of the neurosurgical literature.

METHODS:

A systematic search for meta-analyses from the top neurosurgery journals was conducted. Data relevant to the presence, assessment, and adjustments for publication bias were extracted.

RESULTS:

The search yielded 190 articles. Most of the articles (n = 108, 56.8%) were assessed for publication bias, of which 40 (37.0%) found evidence for publication bias whereas 61 (56.5%) did not. In the former case, only 11 (27.5%) made corrections for the bias using the trim-and-fill method, whereas 29 (72.5%) made no correction. Thus, 111 meta-analyses (58.4%) either did not assess for publication bias or, if assessed to be present, did not adjust for it.

CONCLUSION:

Taken together, these results indicate that publication bias remains largely unaccounted for in neurosurgical meta-analyses.
Unprecedented early-summer heat stress and forecast of coral bleaching on the Great Barrier Reef, 2021-2022
Authors: Spady Blake L. , Skirving William J. , Liu Gang , De La Cour Jacqueline L. , McDonald Cathy J. , Manzello Derek P.
Published: May 2022

The Great Barrier Reef (GBR) is predicted to undergo its sixth mass coral bleaching event during the Southern Hemisphere summer of 2021-2022. Coral bleaching-level heat stress over the GBR is forecast to start earlier than any previous year in the satellite record (1985-present). The National Oceanic and Atmospheric Administration (NOAA) Coral Reef Watch (CRW) near real-time satellite-based heat stress products were used to investigate early-summer sea surface temperature (SST) and heat stress conditions on the GBR during late 2021. As of 14 December 2021, values of instantaneous heat stress (Coral Bleaching HotSpots) and accumulated heat stress over a 12-week running window (Degree Heating Weeks) on the GBR were unprecedented in the satellite record. Further, 89% of GBR satellite reef pixels for this date in 2021 had a positive seven-day SST trend of greater than 0.2 degrees Celsius/week. Background temperatures (the minimum temperature over the previous 29 days) were alarmingly high, with 87% of GBR reef pixels on 14 December 2021 being greater than the maximum SST over that same 29-day period for any year from 1985-2020. The GBR is starting the 2021-2022 summer season with more accumulated heat than ever before, which could have disastrous consequences for the health, recovery, and future of this critical reef system.
Macroinvertebrate-based index of biotic integrity for assessing the ecological condition of Lake Wanchi, Ethiopia
Authors: Kuma Tolera , Tamire Girum , Beneberu Getachew
Published: May 2022

Background: Lake Wanchi is one of the Ethiopian lakes that have huge ecological, socio-economic and aesthetic value. This study was conducted to assess the ecological condition of Lake Wanchi using the macroinvertebrate-based index of biotic integrity between September 2016 and should 2017.

Methods: Four sampling sites (LWS 1, LWS 2, LWS 3, and LWS 4) were purposively selected. A rapid bioassessment protocol criterion was accustomed to categorize the sites. About 1249 macroinvertebrate individuals were collected using the D-frame net with a mesh size of 500µm. Physico-chemical analysis was also done to assess the link between the benthic macroinvertebrate structure and environmental factors within the system.

Results: The benthic index of biotic integrity ranged from 12.54 to 100 and also the sites were categorized into three quality ranks: LWS 1 and 3 as fair, LWS 2 as good, and LWS 4 as very good.

 Conclusions: The study confirmed that Lake Wanchi was largely influenced by agricultural and other anthropogenic factors. This study concluded that the benthic index of biotic integrity is an appropriate tool for water quality and ecological assessment in the lakes.
Simulation model for the dynamics of dengue with asymptomatic transmission and the effect of temperature
Authors: Olarte García Julián Alejandro , Raigosa Osorio Steven , Manrique Arias Oscar Andrés , Abello Muñoz Carlos Alberto , Acosta Minoli Cesar Augusto
Published: May 2022

Background: One of the fastest spreading vector-borne diseases in tropical and subtropical regions is dengue, which generates cost overruns for public health entities. Several factors can influence the dynamics of dengue virus transmission: environmental and climatic (abundance of vectors), interactions between hosts (infections by asymptomatic individuals), and population immunological factors. Given these conditions, it is necessary to carry out theoretical studies based on meteorological factors and asymptomatic transmission that are associated with both the existence of the vector and its incidence, in order to provide a scientific basis for health entities in decision-making.

Methods: A mathematical model based on nonlinear ordinary differential equations is proposed to interpret the dynamics of dengue transmission in humans coupled to the dynamics of the Aedes aegypti species, considering the population of symptomatic and asymptomatic infected humans and the effect of temperature variability. The basic reproduction number was found and some simulation results based on the Runge-Kutta numerical method were obtained.

Results: The simulations showed that the temperature had a directly proportional relationship with the basic reproduction number. The cases of infected people and carrier mosquitoes increased when the temperature peaks increased drastically; in low temperatures the infection persisted with low morbidity due to the survival of asymptomatic people.

Conclusions: High temperatures tolerable by mosquitoes increase their life expectancy and their numbers in the environment which, together with a reservoir of asymptomatic infected people, leads to a higher incidence of the dengue virus in certain seasons or maintains its circulation in seasons of low temperatures, despite lower vector survival rates.
Internal control and supply of medicines in the pharmacy area of the Zarate Health Centre - 2021
Authors: Esteves Pairazaman Ambrocio Teodoro , Cueva Mestanza Ruben Eduardo , Leon Apac Gabriel , Chavez Flores Juana Elvira , Lizarme Arevalo Diana Justina , Caja Clemente Carolina Marisol , Ñañez del Pino Daniel
Published: May 2022

Background: The purpose of this research was to evaluate whether internal control helps the supply of medicines in the pharmacy area of the Zarate health center in 2021.

Methods: The research method was deductive and descriptive-observational. The approach was quantitative, as the analysis was observational based on documentary analysis. It was an applied, non-experimental, cross-sectional design. The population and sample were the documentation of internal control and medicine supply in the pharmacy area of the Zarate health center in 2021. Due to the nature of the research, a checklist was used as a data collection instrument, which was used to collect all the information from the documentation available at the study site.

Results: As main results, it was found that the evaluation of internal control obtained a score of 63 out of 66 possible points, with 95.5% compliance, and the supply variable obtained a score of 37 out of 42 possible points, with 88.1% compliance.

Conclusion: It was found that internal control affects and helps the supply of medicines in the pharmacy area of the Zarate health center in 2021.
Non-technical dimensions of communal wastewater treatment plant sustainability in peri-urban Yogyakarta, Indonesia
Authors: Brontowiyono Widodo , Boving Thomas , Asmara Adelia Anju , Rahmawati Suphia , Yulianto Andik , Wantoputri Noviani Ima , Lathifah Annisa Nur , Andriansyah Yuli
Published: May 2022

Background: This study focuses on identifying non-technical aspects that influence the sustainability of communal wastewater treatment plants (WWTPs) in a peri-urban area of Indonesia.

Methods: A questionnaire survey was conducted by random sampling using a method of descriptive analysis that combines qualitative and quantitative approaches. Economic support for communal WWTPs was measured by the community’s Willingness to Pay (WTP) and Ability to Pay (ATP).

Results: The results indicate that social dimension, such as a community’s level of participation are critically important in sustaining communal WWTPs. In addition, institutional dimension influences the degree of satisfaction a community has toward the WWTP management. This support is reinforced by social capital in the form of a philosophy of mutual cooperation, like gotong royong (cooperation by members of a community to achieve a common goal) and swadaya (self-reliance).

Conclusions: The findings of this study can be used in Indonesia to make policy recommendations for managing and ensuring sustainability of communal WWTPs on a non-technical dimension. Additionally, gotong royong deserves to be promoted internationally as a fundamental value for fostering participation and contribution.
Sustainable housing development dynamics in the Global South: refl ections on theories, strategies and constraints
Authors: Aliu Ibrahim Rotimi
Published: May 2022

Background: Sustainability has been on the front burner of global debates in the 21st century because of the three commons: economic development, social equity and environmental stability. Central to the debate on sustainability is housing. Housing, as a fixed, physical structure can undermine development by constituting threats to the physical environment, and housing as an economic commodity can invigorate the process of development by increasing GDP through diverse job creations and revenue generations. However, the intersection of housing development, physical environment and sustainability in the Global South has been under-reported. Aim: The aim of this paper is to contribute to the debate on sustainable housing provision in the Global South based on three valid questions: How can affordable housing be produced for the teeming population, how can sustainable, quality housing be produced, and how can the impacts of housing on the physical environment be regulated?Results and conclusion: The paper discusses housing deficits, sustainable housing development strategies, challenges of sustainable housing provision and potential solutions to sustainable housing development in the Global South region. This paper has useful policy and practical implications for housing development in developing countries.