bluuebunny/crossref_metadata_2025 huggingface dataset:
Impfstoffe aus Kuba
Authors: Groß Michael
Published: July 2005

Vor einem Jahr publizierte das US‐Magazin Science eine Arbeit, welche den ersten vollständig synthetisch erzeugten Impfstoff vorstellte und seine Wirksamkeit gegen Haemophilus influenzae B (HiB) demonstrierte – einen Erreger, dem in den Entwicklungsländern jährlich mehr als 600.000 Kinder zum Opfer fallen. Die eigentliche Sensation: Der neue Wirkstoff stammt aus dem “Labor für synthetische Antigene” an der Universität von Havanna in Kuba.
Herzinfarkt: Genetische Untersuchungen tragen zum Aufspüren von Hochrisiko‐Patienten bei
Authors: Hengstenberg Christian , Fischer Marcus , Schunkert Heribert
Published: July 2005

Eine aktuelle Studie der Universitäten Regensburg und Lübeck ergab, dass genetische Faktoren an der Ausprägung einer koronaren Herzkrankheit in Form und Stärke maßgeblich beteiligt sind. Einengungen des Hauptherzkranzgefäßes (Hauptstamm) und der ursprungsnah gelegenen (proximalen) Abschnitte der großen Herzkranzgefäße sind die gefährlichsten Stellen für die koronare Herzerkrankung, und genau diese Stellen haben die höchste Vererbungsrate [1]. Die starke Vererbbarkeit von bestimmten schweren Erscheinungsformen der koronaren Herzerkrankung kann eine wichtige Bedeutung für Vorsorge‐Untersuchungen von Verwandten haben.
Gespensterkrebse aus Fernost erobern die Nordsee
Authors: Buschbaum Christian , Schrey Imme
Published: July 2005

In Nord‐ und Ostsee finden sich zunehmend Organismen aus fernen Ländern, die mit Schiffen oder durch Aquakultur in unsere heimischen Gewässer verschleppt werden. Kürzlich ist eine neue Krebsart aus Asien an der Nordseeküste entdeckt worden, die nun massenhaft Hafenanlagen, Boote und Seetonnen besiedelt.
Impact of anastomotic leakage on long-term survival of patients undergoing curative resection for colorectal cancer
Authors: McArdle C S , McMillan D C , Hole D J
Published: July 2005

Background

The impact of anastomotic leakage on immediate postoperative mortality in patients undergoing potentially curative resection for colorectal cancer is well recognized. Its impact on long-term survival is less clear. The aim of the present study was to evaluate the relationship between anastomotic leakage and long-term survival in patients undergoing potentially curative resection for colorectal cancer.

Methods

A total of 2235 patients who underwent potentially curative resection for colorectal cancer between 1991 and 1994 in Scotland were included in the study. Five-year survival rates and adjusted hazard ratios were calculated.

Results

Fourteen (16 per cent) of the 86 patients with an anastomotic leak died within 30 days of surgery compared with 83 (3·9 per cent) of 2149 without a leak. The 5-year cancer-specific survival rate, including postoperative deaths, was 42 per cent in patients with an anastomotic leak compared with 66·9 per cent in those with no leak (P < 0·001). Excluding postoperative deaths, respective values were 50 and 68·0 per cent (P < 0·001). The adjusted relative hazard ratios, for patients with an anastomotic leak compared with those without a leak, and excluding 30-day mortality, were 1·61 (95 per cent confidence interval (c.i.) 1·19 to 2·16; P = 0·002) for overall survival and 1·99 (95 per cent c.i. 1·42 to 2·79; P < 0·001) for cancer-specific survival.

Conclusion

Development of an anastomotic leak is associated with worse long-term survival after potentially curative resection for colorectal cancer.
Effect of alcohols and temperature on the direct chiral resolutions of fipronil, isocarbophos and carfentrazone‐ethyl
Authors: Wang Peng , Jiang Shuren , Liu Donghui , Jia Guifang , Wang Qiuxia , Wang Ping , Zhou Zhiqiang
Published: July 2005

The enantiomeric separations of three pesticides fipronil (asymmetric nitrogen), isocarbophos (asymmetric phosphorus) and carfentrazone‐ethyl (asymmetric carbon) were studied on cellulose‐tri(3,5‐dimethylphenylcarbamate) chiral stationary phase using high‐performance liquid chromatography under normal phase. The mobile phase was n‐hexane with alcohols including ethanol, n‐propanol, iso‐propanol, n‐butanol and iso‐butanol as polar modifiers. The flow rate was 1.0 mL/min with UV detection at 280, 225 and 230 nm for fipronil, isocarbophos and carfentrazone‐ethyl respectively. The influence of the modifiers and their volume content and temperature from 0 to 50°C on the separations was investigated. The chiral stationary phase showed excellent stereoselectivity for the two enantiomers of fipronil and isocarbophos and certain chiral recognition for carfentrazone‐ethyl. Iso‐propanol was more suitable for the chiral separation of isocarbophos and carfentrazone‐ethyl, and iso‐butanol was better for fipronil. The resolutions increased with the decreasing modifier content and temperature for all the three chiral pesticides. Copyright © 2005 John Wiley & Sons, Ltd.
A New Description of the Crystal Structures of Tin Oxide Fluorides.
Authors: Santamaria‐Perez David , Vegas Angel , Mueller Ulrich
Published: July 2005

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Synthesis, Structural and Microstructural Study of Bi4W0.5Ti0.5O8X (X: Cl, Br) Sillen—Aurivillius Intergrowths.
Authors: Avila‐Brande David , Gomez‐Herrero Adrian , Landa‐Canovas Angel R. , Otero‐Diaz L. Carlos
Published: July 2005

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Mixed Layered Oxide Phases NaxLi1‐xNiO2: A Detailed Description of Their Preparation and Structural and Magnetic Identification.
Authors: Holzapfel Michael , Darie Celine , Bordet Pierre , Chappel Eric , Nunez‐Regueiro Maria‐Dolores , de Brion Sophie , Chouteau Gerard , Strobel Pierre
Published: July 2005

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The Ternary Rare‐Earth Polychalcogenides LaSeTe2, CeSeTe2, PrSeTe2, NdSeTe2, and SmSeTe2: Syntheses, Crystal Structures, Electronic Properties, and Charge‐Density‐Wave‐Transitions.
Authors: Fokwa Tsinde Boniface Polequin , Doert Thomas
Published: July 2005

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Synthesis, Characterization and Structure Determination of a Three‐Dimensional Hydrated Potassium Zinc Divanadate: K[Zn2.5V2O7(OH)2] ×H2O.
Authors: Hoyos Dora , Paillaud Jean‐Louis , Simon‐Masseron Angelique , Guth Jean‐Louis
Published: July 2005

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Evolution of the Crystal and Electronic Structures of Magnetic RuSr2‐xLaxGdCu2O8 Superconductors upon La Substitution.
Authors: Hur Su Gil , Park Dae Hoon , Hwang Seong‐Ju
Published: July 2005

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Phase Equilibria in the Dy—Cu—Sn Ternary System.
Authors: Bodak O. I. , Romaka V. V. , Tkachuk A. V. , Romaka L. P. , Stadnyk Yu. V.
Published: July 2005

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Sn2‐2xSbxFexO4 Solid Solutions as Possible Inert Anode Materials in Aluminum Electrolysis.
Authors: Abakumov A. M. , et al. et al.
Published: July 2005

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MoVTeNbO Multifunctional Catalysts: Correlation Between Constituent Crystalline Phases and Catalytic Performance.
Authors: Botella P. , Garcia‐Gonzalez E. , Lopez Nieto J. M. , Gonzalez‐Calbet J. M.
Published: July 2005

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Novel Zirconium—Titanium Phosphates Mesoporous Materials for Hydrogen Production by Photoinduced Water Splitting.
Authors: Kapoor Mahendra P. , Inagaki Shinji , Yoshida Hisao
Published: July 2005

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Synthesis, Crystal Structure, and Solid‐State NMR Spectroscopy of a New Open‐Framework Aluminophosphate (NH4)2Al4(PO4)4 (HPO4)×H2O.
Authors: Zhou Dan , Chen Lei , Yu Jihong , Li Yi , Yan Wenfu , Deng Feng , Xu Ruren
Published: July 2005

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Hydrothermal Synthesis and Structural Study of Lanthanide Orthovanadates, LnVO4 (Ln: Sm, Gd, Dy and Ho).
Authors: Mahapatra S. , Ramanan A.
Published: July 2005

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The Isopropylsulfinyl Group: A Useful Chiral Controller for the Asymmetric Aziridination of Sulfinylimines and the Organocatalytic Allylation of Hydrazones.
Authors: Fernandez Inmaculada , Valdivia Victoria , Gori Beatrice , Alcudia Felipe , Alvarez Eleuterio , Khiar Noureddine
Published: July 2005

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Asymmetric Synthesis Using Sulfinimines (N‐Sulfinyl Imines)
Authors: Davis Franklin A. , et al. et al.
Published: July 2005

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Enantioselective Routes to Sulfoxides Based upon Carbon‐for‐Carbon Substitution Reactions on the Sulfinyl Group
Authors: Cardellicchio Cosimo , Naso Francesco , Capozzi Maria Annunziata M.
Published: July 2005

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Developments of Asymmetric Synthesis Mediated by Chiral Sulfur Reagents
Authors: Blot Virginie , Briere Jean‐Francois , Davoust Marion , Miniere Stephanie , Reboul Vincent , Metzner Patrick
Published: July 2005

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Fe—HCl: An Efficient Reagent for Deprotection of Oximes as well as Selective Oxidative Hydrolysis of Nitroalkenes and Nitroalkanes to Ketones.
Authors: Pradhan Prasun K. , Dey Sumit , Jaisankar Parasuraman , Giri Venkatachalam S.
Published: July 2005

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Quaternary Ammonium Dendrimers as Lewis Base Catalysts for Mukaiyama—Aldol Reaction.
Authors: Mizugaki Tomoo , Hetrick Casey E. , Murata Makoto , Ebitani Kohki , Amiridis Michael D. , Kaneda Kiyotomi
Published: July 2005

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Heterocyclization of 2‐Chloro‐1‐cyano‐1‐diethoxyphosphoryl‐2‐trifluoromethylethylene and 2‐Chloro‐2‐chlorodifluoromethyl‐1‐cyano‐1‐diethoxyphosphorylethylene.
Authors: Shidlovskii A. F. , Peregudov A. S. , Averkiev B. B. , Antipin M. Yu. , Chkanikov N. D.
Published: July 2005

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Synthesis of Novel Naphtho[2,1‐b]furo‐pyrazolyl, ‐isoxazolyl and ‐pyridyl Derivatives as Potential Antimicrobial Agents.
Authors: Mahadevan K. M. , Basavaraj K. M. , Mathias D. A. Prathima , Vaidya V. P.
Published: July 2005

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A One‐Pot Multicomponent Coupling Reaction for the Stereocontrolled Synthesis of Allyl‐Substituted Cyclopropanes.
Authors: Chen Chao , Xi Chanjuan , Shi Yongling , Hong Xiaoyin
Published: July 2005

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Chemoselective Reduction of Aldehydes in the Presence of Ketones with NaBH4 in Polyethylene Glycol Dimethyl Ethers.
Authors: Tanemura Kiyoshi , Suzuki Tsuneo , Nishida Yoko , Satsumabayashi Koko , Horaguchi Takaaki
Published: July 2005

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Preparation of C2‐Symmetric Bicyclo[2.2.2]octa‐2,5‐diene Ligands and Their Use for Rhodium‐Catalyzed Asymmetric 1,4‐Addition of Arylboronic Acids.
Authors: Otomaru Yusuke , Okamoto Kazuhiro , Shintani Ryo , Hayashi Tamio
Published: July 2005

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Titanocene(II)‐Promoted Reactions of 2‐(Alk‐1‐yn‐1‐yl)‐2‐(trialkylsilyl)‐1,3‐dithianes with Olefins and Carbonyls
Authors: Takeda Takeshi , Kuroi Shuichi , Ozaki Makoto , Tsubouchi Akira
Published: July 2005

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Alkenylcarbene Ruthenium Arene Complexes as Initiators of Alkene Metathesis: An Enyne Creates a Catalyst that Promotes Its Selective Transformation.
Authors: Castarlenas Ricardo , Eckert Matthieu , Dixneuf Pierre H.
Published: July 2005

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Dendritic Nanoreactor Encapsulating Rh Complex Catalyst for Hydroformylation.
Authors: Mizugaki Tomoo , Miyauchi Yasuaki , Murata Makoto , Ebitani Kohki , Kaneda Kiyotomi
Published: July 2005

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Bulky Diarylammonium Arenesulfonates as Selective Esterification Catalysts.
Authors: Ishihara Kazuaki , Nakagawa Shoko , Sakakura Akira
Published: July 2005

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A Convenient Protocol for C—H Oxidation Mediated by an Azido Radical Culminating in Ritter‐Type Amidation.
Authors: Nair Vijay , Suja T. D. , Mohanan Kishor
Published: July 2005

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Microwave‐Assisted Deoximation under Solvent‐Free Conditions Using Bi(NO3)3×5H2O Supported onto Montmorillonite K‐10.
Authors: Mojtahedi Mohammad M. , Heravi Majid M.
Published: July 2005

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A Simple and Practical Synthetic Protocol for Thioacetalization of Carbonyl Compounds.
Authors: Khan Abu T. , Mondal Ejabul
Published: July 2005

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Radical Allylation, Vinylation, Alkynylation, and Phenylation Reactions of α‐Halo Carbonyl Compounds with Organoboron, Organogallium, and Organoindium Reagents.
Authors: Takami Kazuaki , Usugi Shin‐ichi , Yorimitsu Hideki , Oshima Koichiro
Published: July 2005

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The Facile Preparation of Primary and Secondary Amines via an Improved Fukuyama—Mitsunobu Procedure. Application to the Synthesis of a Lung‐Targeted Gene Delivery Agent.
Authors: Guisado Cristina , Waterhouse Jodie E. , Price Wayne S. , Jorgensen Michael R. , Miller Andrew D.
Published: July 2005

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Stereoselective α‐Hydrazination of α,β‐Unsaturated Carboxylates Catalyzed by Manganese(III) Complex with Dialkylazodicarboxylate and Phenylsilane.
Authors: Sato Mitsuo , Gunji Yasuhiko , Ikeno Taketo , Yamada Tohru
Published: July 2005

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The Novel and Efficient Direct Synthesis of N,O‐Acetal Compounds Using a Hypervalent Iodine(III) Reagent: An Improved Synthetic Method for a Key Intermediate of Discorhabdins.
Authors: Harayama Yu , Yoshida Masako , Kamimura Daigo , Kita Yasuyuki
Published: July 2005

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Studies on t‐BuOK‐Catalyzed Michael Addition of 1,2‐Allenic Ketones with 2‐Substituted Diethyl Malonates: Highly Selective Synthesis of β,γ‐Unsaturated Enones.
Authors: Ma Shengming , Yu Shichao , Qian Wenjian
Published: July 2005

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Reductive Cleavage of the Carbon—Sulfur Bond by Samarium/Cp2TiCl2 System for the Synthesis of Dialkyl Disulfides.
Authors: Jia Xue‐Shun , Zhang Yong‐Min
Published: July 2005

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α,β‐Unsaturated α′‐Halomethylsulfones: Prepackaged Ramberg—Baecklund Reagents for Tandem Synthetic Processes
Authors: Block Eric , Jeon Hak Rim , Putman David , Zhang Shao‐Zhong
Published: July 2005

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Functionalized 2‐Chlorocyclopropanecarboxylates Through the MIRC Reaction.
Authors: Giubellina Nicola , De Kimpe Norbert
Published: July 2005

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Asymmetric Cyclopropanantion of Optically Active Vinyl Sulfoxides: A New Synthetic Approach to Biologically Active Compounds
Authors: Midura Wanda H.
Published: July 2005

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Formation and Structures of 2,5‐Di‐tert‐butylcyclopentadienone Dimers.
Authors: Abakumov G. A. , Vavilina N. N. , Zakharov L. N. , Kurskii Yu. A. , Nevodchikov V. I. , Shavyrin A. S.
Published: July 2005

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Organocatalytic Transformation of 1,3‐Diketones into Optically Active Cyclohexanones.
Authors: Gryko Dorota
Published: July 2005

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Synthesis of (Z)‐1‐Bromo‐1‐alkenes and Terminal Alkynes from anti‐2,3‐Dibromoalkanoic Acids by Microwave‐Induced Reaction.
Authors: Kuang Chunxiang , Yang Qing , Senboku Hisanori , Tokuda Masao
Published: July 2005

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Regio‐ and Stereoselective Reductions of gem‐Difluorinated Vinyloxiranes.
Authors: Ueki Hisanori , Chiba Takashi , Kitazume Tomoya
Published: July 2005

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Practical and Regioselective Halogenations of Aromatic Compounds Using Tetrabutylammonium Peroxydisulfate
Authors: Park Min Young , Yang Seung Gak , Kim Yong Hae
Published: July 2005

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Lewis Base Catalyzed Trifluoromethylation of Aldimines with (Trifluoromethyl)trimethylsilane.
Authors: Kawano Yoshikazu , Fujisawa Hidehiko , Mukaiyama Teruaki
Published: July 2005

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Copper‐Catalyzed Aryl Amination in Aqueous Media with 2‐Dimethylaminoethanol Ligand.
Authors: Lu Zhikuan , Twieg Robert J.
Published: July 2005

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Microwave‐Assisted Cleavage of Epoxides with Amines in the Presence of the Catalytic Zn(OAc)2/1,7‐Bis(2‐benzoic acid)‐1,4,7‐trioxaheptane (ZnBBATOH).
Authors: Eshghi Hossein , Rahimizadeh Mohammad , Shoryabi Abolhassan
Published: July 2005

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A Practical Diastereoselective Synthesis of syn‐α‐Hydroxyaminonitriles.
Authors: Abdillah Fatoumia , Almeras Loic , Leclerc Eric , Mangeney Pierre , Vrancken Emmanuel
Published: July 2005

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Direct and Highly Efficient Synthesis of (Z)‐Allyl Iodides from Baylis—Hillman Adducts Promoted by TMSCl/NaI System.
Authors: Li Jian , Wang Xiaoxia , Zhang Yongmin
Published: July 2005

For Abstract see ChemInform Abstract in Full Text.
Petasis Boronic Mannich Reactions of Electron‐Poor Aromatic Amines under Microwave Conditions.
Authors: Follmann Markus , Graul Franziska , Schaefer Thorsten , Kopec Sebastian , Hamley Peter
Published: July 2005

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Biocatalytic Racemization of α‐Hydroxycarboxylic Acids at Physiological Conditions.
Authors: Glueck Silvia M. , Larissegger‐Schnell Barbara , Csar Katrin , Kroutil Wolfgang , Faber Kurt
Published: July 2005

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Metallophosphite‐Induced Nucleophilic Acylation of α,β‐Unsaturated Amides: Facilitated Catalysis by a Diastereoselective Retro [1,4] Brook Rearrangement.
Authors: Nahm Mary R. , Linghu Xin , Potnick Justin R. , Yatees Christopher M. , White Peter S. , Johnson Jeffrey S.
Published: July 2005

For Abstract see ChemInform Abstract in Full Text.
Catalytic, Asymmetric aza‐Baylis—Hillman Reaction of N‐Sulfonated Imines with 2‐Cyclohexen‐1‐one and 2‐Cyclopenten‐1‐one in the Presence of a Chiral Phosphine Lewis Base.
Authors: Shi Min , Li Chao‐Qun
Published: July 2005

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Synthesis of New Chiral Hydroxy Oxazolines and Their Use in the Catalytic Asymmetric Phenyl Transfer to Aldehydes.
Authors: Bolm Carsten , Schmidt Frank , Zani Lorenzo
Published: July 2005

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Unusual Reaction of Resorcinol or Methylresorcinol with 2‐Dimethylamino‐1,1‐dimethylpropanal.
Authors: Burilov A. R. , Gazizov A. S. , Volodina Yu. M. , Kamalov R. M. , Pudovik M. A. , Habicher W. D. , Konovalov A. I.
Published: July 2005

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A First P,N‐Bidentate Phosphite with a Chiral Ketimine Fragment. Catalytic Properties of Its RhI and PdII Complexes in Comparison with Those of Phosphine Analogues.
Authors: Tsarev V. N. , Lyubimov S. E. , Zheglov S. V. , Shiryaev A. A. , Davankov V. A. , Gavrilov K. N.
Published: July 2005

For Abstract see ChemInform Abstract in Full Text.
Stereoselective Preparation of Spiran‐Bridged, Sandwiched Bisarenes.
Authors: Rolandsgard Marit , Baldawi Saad , Sirbu Doina , Bjoernstad Vidar , Roemming Christian , Undheim Kjell
Published: July 2005

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Use of Cyclic Allylic Bromides in the SnCl2/Cu‐Mediated Aqueous Carbonyl Allylation Reaction.
Authors: Tan Xiang‐Hui , Tao Chuan‐Zhou , Hou Yong‐Quan , Luo Lin , Liu Lei , Guo Qing‐Xiang
Published: July 2005

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N,N,N′‐Trialkyl‐1,8‐diaminonaphthalenes: Convenient Method of Preparation from Protonated Proton Sponges and the First X‐Ray Information.
Authors: Ozeryanskii V. A.. , Pozharskii A. F. , Koroleva M. G. , Shevchuk D. A. , Kazheva O. N. , Chekhlov A. N. , Shilov G. V. , Dyachenko O. A.
Published: July 2005

For Abstract see ChemInform Abstract in Full Text.
The Cyclooligomerization of Arylethynes in Ionic Liquids Catalyzed by Ruthenium Porphyrins: A Case of Real Catalyst Recycling.
Authors: Conte Valeria , Elakkari Elfituri , Floris Barbara , Mirruzzo Valentina , Tagliatesta Pietro
Published: July 2005

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Novel 2‐Amino‐3‐(2,4‐dinitrophenylamino) Derivatives of 1,4‐Naphthoquinone.
Authors: Win Thida , Bittner Shmuel
Published: July 2005

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Unprecedented Ligand Dependent SN2′ Mechanism on the Palladium‐Catalyzed Nucleophilic Substitution to Bicyclic Dienyl Acetates.
Authors: Daimon Hisashi , Kitamura Takahiro , Kawahara Tamotsu , Shimizu Isao
Published: July 2005

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Cationic PdII Complexes of Fesulphos Ligands: Highly Efficient Catalysts for the Enantioselective Ring Opening of Oxa‐ and Azabicyclic Alkenes with Dialkylzinc Reagents
Authors: Cabrera Silvia , Alonso Ines , Gomez Arrayas Ramon , Familiar Olga , Carretero Juan C.
Published: July 2005

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Synthesis and Stereoselective Functionalization of Sulfur‐Containing Silylated Heterocycles
Authors: Capperucci Antonella , Castagnoli Giulio , Degl'Innocenti Alessandro , Malesci Irene , Nocentini Tiziano
Published: July 2005

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Vanadium‐Catalyzed Asymmetric Epoxidation of Allylic Alcohols Mediated by (+)‐Norcamphor‐Derived Hydroperoxide.
Authors: Lattanzi Alessandra , Piccirillo Sandro , Scettri Arrigo
Published: July 2005

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Studies on Pd(II)‐Catalyzed Synthesis of (Z)‐α‐Haloalkylidene‐β‐lactones from Cyclocarbonylation of 2‐Alkynols and the Subsequent Coupling Reactions.
Authors: Ma Shengming , Wu Bin , Jiang Xuefeng , Zhao Shimin
Published: July 2005

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Two‐Step Syntheses of 2,4,6‐Triisopropylbenzenesulfonyl Aziridines.
Authors: Huang Jianhui , O'Brien Peter
Published: July 2005

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Novel Carbonyl Bromoallylation/Heck Reaction Sequence. Stereocontrolled Access to Bicyclic β‐Lactams.
Authors: Alcaide Benito , Almendros Pedro , Rodriguez‐Acebes Raquel
Published: July 2005

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Diastereoselective Route to Novel Fused or Bridged Tricyclic β‐Lactams Through Intramolecular Nitrone—Alkene Cycloaddition of 2‐Azetidinone‐Tethered Alkenylaldehydes — Synthetic Applications to Carbacephams and Cyclic β‐Amino Acid Derivatives.
Authors: Alcaide Benito , Saez Elena
Published: July 2005

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Three‐Component Reactions Involving Zwitterionic Intermediates for the Construction of Heterocyclic Systems: One‐Pot Synthesis of Highly Functionalized γ‐Iminolactones.
Authors: Esmaeili Abbas Ali , Zendegani Hamid
Published: July 2005

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Cyclization of δ‐[(S)‐1‐Phenylethyl]amino Alcohols to Form Chiral 1,3‐Disubstituted Phthalanes.
Authors: Shishkina I. N. , Kuznetsova A. A. , Dem'yanovich V. M.
Published: July 2005

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Ytterbium(III) Trifluoromethanesulfonate Catalyzed Friedel—Crafts Acylation of 1‐Methylpyrrole in Ionic Liquid.
Authors: Su Weike , Wu Chunlei , Su Hao
Published: July 2005

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Direct C‐Arylation of Free (NH)‐Indoles and Pyrroles Catalyzed by Ar—Rh(III) Complexes Assembled in situ.
Authors: Wang Xiang , Lane Benjamin S. , Sames Dalibor
Published: July 2005

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Reaction Between Isocyanides and Dialkyl Acetylenedicarboxylates in the Presence of 2,4‐Dihydro‐3H‐pyrazol‐3‐ones. One‐Pot Synthesis of Highly Functionalized 7‐Oxo‐1H,7H‐pyrazolo[1,2‐a]pyrazoles.
Authors: Adib Mehdi , Sayahi Mohammad Hosein , Aghaaliakbari Behnaz , Bijanzadeh Hamid Reza
Published: July 2005

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A Domino Type One‐Flask Synthesis of 1‐Substituted‐5‐aminoimidazole‐4‐carboxamides and Ring Transformation to Pyrazine under Microwave Through Suitable Aminoimidazoliumcarboxamide.
Authors: Chattopadhyay Gautam , Saha Tapas K.
Published: July 2005

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Synthetic Approaches to Sterically Hindered N‐Arylimidazoles Through Copper‐Catalyzed Coupling Reactions.
Authors: Alcalde Ermitas , Dinares Immaculada , Rodriguez Sandra , Garcia de Miguel Cristina
Published: July 2005

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Highly Diastereoselective [3 + 2] Cycloadditions Between Non‐Racemic p‐Tolylsulfinimines and Iminoesters: An Efficient Entry to Enantiopure Imidazolidines and Vicinal Diamino Alcohols
Authors: Viso Alma
Published: July 2005

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Montmorillonite K‐10 Mediated Erlenmeyer Synthesis of 4‐Arylmethylene‐2‐phenyl‐5(4H)‐oxazolones.
Authors: Karade N. N. , Shirodkar S. G. , Dhoot B. M. , Waghmare P. B.
Published: July 2005

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Regio‐ and Stereoselective Formation of 1,3‐Oxathiolanes by Reactions of Thiocarbonyl Compounds with Oxiranes
Authors: Fu Changchun , Blagoev Milen , Linden Anthony , Heimgartner Heinz
Published: July 2005

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Synthesis, in vitro‐Antimycobacterial Activity and Cytotoxicity of Some Alkyl α‐(5‐Aryl‐1,3,4‐thiadiazole‐2‐ylthio)acetates.
Authors: Foroumadi Alireza , Soltani Fatemeh , Moallemzadeh‐Haghighi Hamideh , Shafiee Abbas
Published: July 2005

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Synthesis of Biogenetically Possible 2‐Phenyl‐4‐oxopyrano[2,3‐a]carbazoles.
Authors: Vandana T. , Prasad K. J. Rajendra
Published: July 2005

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Cyclization of N,N′‐Bis(salicylidene)diamines with Carbon Suboxide.
Authors: Chimenti F. , Secci D. , Bolasco A. , Chimenti P. , Granese A.
Published: July 2005

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A New Method for the Preparation of Polyfluoroalkanedithiocarboxylates.
Authors: Timoshenko Vadim M. , Tkachenko Alexander V. , Shermolovich Yuriy G.
Published: July 2005

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Synthesis of 1,3‐Diaryl‐4‐(pyridin‐4‐yl)pyrazoles as a New Class of Pyrazole Based Diaryl Heterocycles.
Authors: Reddy G. Jagath , Pallavi K. , Reddy R. Shailaja , Rao K. Srinivasa
Published: July 2005

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Chemistry of N,N‐Bis(silyloxy)enamines. Part 7. Quaternization of Tertiary Amines and Nitrogen‐Containing Heterocycles by N,N‐Bis(silyloxy)enamines.
Authors: Lesiv A. V. , Ioffe S. L. , Strelenko Yu. A. , Danilenko V. M.
Published: July 2005

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Photochemical Synthesis of Benzoxazolo[3,2‐b]isoquinolin‐11‐one and Isoquinolino[3,2‐b][1,3]benzoxazin‐11‐one under Basic Conditions.
Authors: Senthilvelan A. , Thirumalai D. , Ramakrishnan V. T.
Published: July 2005

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Synthetic Approaches Towards 5H‐[1]Benzopyrano[3,4‐c]pyridin‐5‐ones.
Authors: Girgis Adel S. , Hosni Hanaa M. , Kalmouch Atef
Published: July 2005

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A Convenient Synthesis of Benzo[g]pyrrolo[3,2‐c]quinoline‐6,11‐diones.
Authors: Tapia Ricardo A. , Lopez Claudio , Morello Antonio , Maya Juan Diego , Valderrama Jaime A.
Published: July 2005

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Cobalt(II) Chloride or Manganese(II) Chloride or Tin(II) Chloride Promoted One‐Pot Synthesis of Dihydropyrimidin‐2(1H)‐ones Using Microwave Irradiation.
Authors: Kumar Sanjay , Saini Anil , Sandhu Jagir S.
Published: July 2005

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One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones/‐thiones Catalyzed by Zinc Chloride: An Improved Procedure for the Biginelli Reaction Using Microwaves under Solvent‐Free Condition.
Authors: Pasha M. A. , Swamy N. Ramachandra , Jayashankara V. P.
Published: July 2005

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Single‐Step Synthesis of Substituted 7‐Aminopyrano[2,3‐d]pyrimidines.
Authors: Shestopalov A. A. , Rodinovskaya L. A. , Shestopalov A. M. , Litvinov V. P.
Published: July 2005

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Expanding the Substitution Pattern of 2(1H)‐Pyrazinones via Suzuki and Heck Reactions.
Authors: Azzam Rasha , De Borggraeve Wim M. , Compernolle Frans , Hoornaert Georges J.
Published: July 2005

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Fused Polycyclic Nitrogen—Containing Heterocycles. Part 11. 4‐Hydroxy‐3,5‐diphenyl‐2‐phenyliminothiazolidines as New Key Compounds in the Synthesis of Thiazolo[3,4‐a]quinoxaline Derivatives.
Authors: Mamedov V. A. , Nurkhametova I. Z. , Kotovskaya S. K. , Gubaidullin A. T. , Levin Ya. A. , Litvinov I. A. , Charushin V. N.
Published: July 2005

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A Simple and Convenient Procedure for the Synthesis of 1‐Aminophosphonates from Aromatic Aldehydes.
Authors: Kaboudin Babak , Moradi Khavar
Published: July 2005

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Reactions of 1,2‐Ethanedithiol and 2‐Mercaptoethanol with Unsaturated Derivatives of Four‐Coordinate Phosphorus Acids.
Authors: Khusainova N. G. , Mostovaya O. A. , Berdnikov E. A. , Efremov Yu. Ya. , Sharafutdinova D. R. , Cherkasov R. A.
Published: July 2005

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Transition Metal Complexes of Fesulphos Ligands in Enantioselective Catalytic Transformations
Authors: Arrayas Ramon Gomez , Mancheno Olga Garcia , Cabrera Silvia , Carretero Juan Carlos
Published: July 2005

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Synthesis and Chemistry of New Central and Planar Chiral Sulfur‐Containing Ferrocenyl Compounds
Authors: Bernardi Luca , Bonini Bianca Flavia , Comes‐Franchini Mauro , Dessole Gabriella , Fochi Mariafrancesca , Ricci Alfredo
Published: July 2005

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Approaches to Sesquiterpenes Containing Three Contiguous Quaternary Carbon Atoms. Synthesis of 3‐Methoxythapsene.
Authors: Srikrishna A. , Ramachary D. B.
Published: July 2005

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Application of the Criegee Rearrangement in Singlet Oxygen Reaction: A High Yield of Diosone from the Photooxygenation of Pseudodiosgenin Diacetate.
Authors: Zhang Yan , Zeng Zhang‐Hua , Liu Yong‐Yong , Cheng Xue‐Xin , Wang Xue‐Song , Zhang Bao‐Wen
Published: July 2005

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Polymer‐Supported Ferric Chloride as a Heterogeneous Catalyst for Chemoselective Deprotection of Acetonides.
Authors: Chari M. Adharvana , Syamasundar K.
Published: July 2005

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A Straightforward and Flexible [4 + 2] Route to β‐C‐Naphthyl‐2‐deoxy‐glycosides Through Tandem Hydroboration‐Ketal Reduction: De Novo Access to C‐Naphthyl‐6‐fluoro and 6,6‐Difluoro 2‐Deoxyglycosides.
Authors: Vu Nguyen Quang , Leconte Stephane , Brown Eric , Gree Danielle , Gree Rene , Dujardin Gilles
Published: July 2005

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Neighboring Group Participation of 9‐Anthracenylmethyl Group in Glycosylation: Preparation of Unusual C‐Glycosides.
Authors: Kulkarni Suvarn S. , Liu Yi‐Hung , Hung Shang‐Cheng
Published: July 2005

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Use of Allylic Boranes in Organic Syntheses. Synthesis of an Analogue of the Alkaloid Flustrabromine.
Authors: Zhun I. V. , Ignatenko A. V.
Published: July 2005

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Some Reactions of 3‐Chloroisoindolium Salts with Nucleophiles: Access to Isoindole Derivatives and Ellipticine Analogues as Potential Antiviral Agents.
Authors: Hamed Atef A.
Published: July 2005

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Cymodienol and Cymodiene: New Cytotoxic Diarylheptanoids from the Sea Grass Cymodocea nodosa.
Authors: Kontiza Ioanna , Vagias Constantinos , Jakupovic Jasmin , Moreau Dimitri , Roussakis Christos , Roussis Vassilios
Published: July 2005

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Total Synthesis of Polypropionate Natural Products: Application of New Sulfur Dioxide Chemistry
Authors: Craita C. , Bouchez L. , Turks M. , Huang X. , Fonquerne F. , Murcia M. C. , Vogel P.
Published: July 2005

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Diastereocontrolled Synthesis of Highly Functionalized Spiroketals: Application to the Synthesis of a Precursor of the C12—C25 Fragment of Bafilomycin A1.
Authors: Lopez Roman , Poupon Jean‐Christophe , Prunet Joelle , Ferezou Jean‐Pierre , Ricard Louis
Published: July 2005

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A New Synthesis of (Z,E)‐Undec‐5‐enoic Acids, the Sex Pheromone of the Varied Carpet Beetle Anthrenus verbasci
Authors: Bykov V. I. , Goletiani A. R. , Butenko T. A. , Finkelshtein E. Sh.
Published: July 2005

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The Development of Cyclophosphate Crystal Chemistry
Authors: Durif Andre
Published: July 2005

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Magnetic Couplings in MM′X Compounds of Cu2Sb Type of Structure (M,M′: d‐Metals, X: p‐Elements as P, As, Sb,...)
Authors: Fruchart Daniel
Published: July 2005

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Some New Molecular Hydrides Stabilized and Characterized with the Aid of the Matrix‐Isolation Technique
Authors: Himmel Hans‐Joerg
Published: July 2005

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The Fluoride Route to New Zeolites
Authors: Villaescusa Luis A. , Camblor Miguel A.
Published: July 2005

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Synthesis and Characterization of Ib‐VI Nanoclusters
Authors: Dehnen Stefanie , Eichhoefer Andreas , Corrigan John F. , Fenske Dieter
Published: July 2005

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Ferromagnetic Coupling Strength and Electron‐Doping Effects in Double Perovskites
Authors: Fontcuberta J. , Rubi D. , Frontera C. , Garcia‐Munoz J. L. , Wojcik M. , Jedryka E. , Nadolski S. , Izquierdo M. , Avila J. , Asensio M. C.
Published: July 2005

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En Route to Complete Design of Heterogeneous Catalysts
Authors: Kung Harold H. , Kung Mayfair C.
Published: July 2005

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Modelling of Magneto‐Mechanical Behavior of Ni—Mn—Ga Single Crystals
Authors: Kiang Jademond , Tong Liyong
Published: July 2005

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Subvalent Compounds Featuring Direct Metal—Metal Bonds: The Zn—Zn Bond in [(C5Me5)2Zn2]
Authors: Schnepf Andreas , Himmel Hans‐Joerg
Published: July 2005

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Cooperative Magnetic Behavior in Metal—Dicyanamide Complexes
Authors: Manson Jamie L.
Published: July 2005

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Chemistry and Biology of Sphingolipids
Authors: Liao Jiayu , Tao Junhua , Lin Guoqiang , Liu Dingguo
Published: July 2005

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Attachment of Organic Layers to Conductive or Semiconductive Surfaces by Reduction of Diazonium Salts
Authors: Pinson Jean , Podvorica Fetah
Published: July 2005

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Modified Zirconia Solid Acid Catalysts for Organic Synthesis and Transformations
Authors: Reddy Benjaram M. , Sreekanth Pavani M. , Reddy Vangala R.
Published: July 2005

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Synthesis of Novel Hydroxamate and Non‐Hydroxamate Histone Deacetylase Inhibitors
Authors: Curtin Michael L.
Published: July 2005

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New Developments in Polymer‐Supported Reagents, Scavengers and Catalysts for Organic Synthesis
Authors: Bhattacharyya Sukanta
Published: July 2005

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Benzylic Grignard Reagents
Authors: Yanagisawa A.
Published: July 2005

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Iminium Salts
Authors: Tehrani K. Abbaspour , De Kimpe N.
Published: July 2005

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Thioaldehydes
Authors: Collier S. J.
Published: July 2005

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Olefin Metatheses and Related Reactions Initiated by Carbene Derivatives of Metals in Low Oxidation States
Authors: Katz Thomas J.
Published: July 2005

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The Intermolecular Pauson—Khand Reaction
Authors: Gibson Susan E. , Mainolfi Nello
Published: July 2005

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A Novel Generation of Polyethertoxin Synthesis
Authors: Hintermann Lukas
Published: July 2005

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Synthesis of Dimethyl Heterocyclic‐o‐dicarboxylates Using Dimethyl Acetylenedicarboxylate
Authors: Tominaga Yoshinori , Ueda Kazuo
Published: July 2005

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Synthesis of Functionalized Compounds Containing Pyridazine and Related Moieties
Authors: Svete Jurij
Published: July 2005

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Synthesis of Biologically Active Pyridazinoquinoxalines
Authors: Kurasawa Yoshihisa , Kim Ho Sik
Published: July 2005

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Pyridazine Derivatives as Novel Acyl‐CoA:Cholesterol Acyltransferase (ACAT) Inhibitors
Authors: Gelain Arianna
Published: July 2005

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Investigation of Ultrasonic Velocity in Organic Liquids on the Saturation Curve
Authors: Neruchev Yu. A. , Bolotnikov M. F. , Zotov V. V.
Published: July 2005

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Viral Prophylaxis in Organ Transplant Patients
Authors: Slifkin Michelle , Doron Shira , Snydman David R.
Published: July 2005

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A Cyclic Peptide (L1AD3) Induces Early Signs of Apoptosis in Human Leukemic T‐Cell Lines
Authors: Smith Charles A. , Hinman Channing L.
Published: July 2005

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Microwave Spectroscopic Properties of CH2DOH, CHD2OH, CH2DOD, and CHD2OD
Authors: Quade C. Richard , Su Chun Fu
Published: July 2005

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High‐Resolution Solid‐State NMR Studies of Inclusion Complexes
Authors: Potrzebowski Marek J. , Kazmierski Slawomir
Published: July 2005

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Frequent Analytical—Experimental Problems in Lipase‐Mediated Synthesis in Solvent‐Free Systems and How to Avoid Them
Authors: Foresti M. L. , Ferreira M. L.
Published: July 2005

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Self‐Organizing Maps for the Analysis of NMR Spectra
Authors: Dow Linda K. , Kalelkar Sandeep , Dow Ernst R.
Published: July 2005

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NMR Studies of Insulating, Metallic, and Superconducting Fullerides: Importance of Correlations and Jahn—Teller Distortions
Authors: Brouet V. , Alloul H. , Garaj S. , Forro L.
Published: July 2005

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Prognostic impact of BRCA1 pathogenic and BRCA1/BRCA2 unclassified variant mutations in patients with ovarian carcinoma
Authors: Majdak Ewa Joanna , Debniak Jaroslaw , Milczek Tomasz , Cornelisse Cees J. , Devilee Peter , Emerich Janusz , Jassem Jacek , De Bock Geertruida Hendrika
Published: July 2005

BACKGROUND

The clinical relevance of BRCA1/2 alterations in ovarian carcinoma patients is debatable. Our aim was to determine factors influencing the risk of recurrence and death in ovarian carcinoma patients with BRCA pathogenic and unclassified variant mutations.

METHODS

A consecutive series of 205 women with primary ovarian carcinoma were screened for mutations in BRCA1 and BRCA2 genes using a conformational sensitive gel electrophoresis and direct sequencing. Data regarding medical and familial history were collected using questionnaires. Clinical and pathologic data were extracted from medical records.

RESULTS

Unclassified variant mutations in BRCA1 or BRCA2 genes were found in 16 (8%) patients, and BRCA1 pathogenic mutations were found in 18 (9%) patients. No pathogenic mutation was found in BRCA2 gene. Multivariate analysis showed that BRCA1 pathogenic mutation was an independent predictor of reduced risk of relapse and death (Hazard ratios [HR] 0.52 [confidence interval {CI} 0.28–0.98] and 0.38 [CI 0.10–0.96], respectively). Unclassified variant mutation did not affect recurrence and survival (HR 0.84 [CI 0.43–1.66] and 0.94 [CI 0.48–1.82], respectively). Other factors associated with reduced risk of relapse and death were complete pathologic remission at second‐look laparotomy and family history of breast and ovarian carcinoma, respectively. Recurrence and death outcomes among unclassified variant mutation carriers did not differ significantly from those in sporadic cases.

CONCLUSIONS

Patients with BRCA1 pathogenic mutation seem to have reduced risk of recurrence and death. These results should be interpreted with caution as they may be influenced by more intensive treatment, better response to cisplatin, and younger age of mutation carriers. Clinical relevance of BRCA1/2 unclassified variant mutations warrants further studies. Cancer 2005. © 2005 American Cancer Society.
Leukemic transformation of polycythemia vera
Authors: Passamonti Francesco , Rumi Elisa , Arcaini Luca , Castagnola Carlo , Lunghi Monia , Bernasconi Paolo , Giovanni Della Porta Matteo , Columbo Nora , Pascutto Cristiana , Cazzola Mario , Lazzarino Mario
Published: July 2005

BACKGROUND

Acute leukemia (AL) may occur as rare and late event of polycythemia vera (PV).

METHODS

The current study included 23 patients who developed acute leukemia in a cohort of 414 consecutive PV patients with long‐term observation (3208 person years of follow‐up). Kaplan–Meier Product‐Limit method was used to estimate the cumulative probability of survival; Gehan–Wilcoxon test was applied to compare survival in different groups of patients.

RESULTS

Median age was 68 years, and 18 patients (78%) were > 60 years of age. At diagnosis of AL, most patients had a white blood count > 10 × 109/L (n = 17; 74%), Hgb < 10 g/dL (n = 13; 57%), and platelet count > 50 × 109/L (n = 17; 74%). Of 14 patients in whom cytogenetic analysis was available at leukemic transformation, 12 showed high‐risk abnormalities including complex karyotype (n = 10), del (7)(q22) sole (n = 1) and del (X)(q26) sole (n = 1), whereas 2 had a normal karyotype. In patients whose karyotype was available at diagnosis of PV, cytogenetic evolution was documented at progression to AL. Treatment consisted of supportive care and/or low‐dose chemotherapy (n = 15), or induction chemotherapy (n = 8). This included idarubicin plus cytarabine (n = 3), high‐dose cytarabine (n = 4), and fludarabine‐based regimen (n = 1). Allogenic stem cell transplantation was offered to a single patient, who is alive at Day + 70. The outcome of patients was poor, with a median survival of 2.9 months (range, 0.6–20.1 mos), with no significant differences between palliation and intensive treatments.

CONCLUSIONS

AL following PV has distinct clinical and biologic features. Outcome of patients is poor irrespective of the treatment employed. Cancer 2005. © 2005 American Cancer Society.
Spectrum and prevalence of BRCA1 and BRCA2 germline mutations in Sardinian patients with breast carcinoma through hospital‐based screening
Authors: Palomba Grazia , Pisano Marina , Cossu Antonio , Budroni Mario , Dedola Maria F. , Farris Antonio , Contu Antonio , Baldinu Paola , Tanda Francesco , Palmieri Giuseppe
Published: July 2005

BACKGROUND

Factors that are predictive of carrying BRCA1 and BRCA2 germline mutations in patients with breast carcinoma are awaited widely. The genetically homogeneous Sardinian population may be useful for defining the role of such genetic alterations further through a clinical evaluation program.

METHODS

One hundred two of 659 patients with breast carcinoma (15.5%) who were collected consecutively had a family history of breast carcinoma and were screened for BRCA1/2 mutations by denaturing high‐performance liquid chromatography and DNA sequencing.

RESULTS

Three deleterious germline BRCA1/2 mutations were detected in 15 of 102 families (14.7%), including 13 families (86.7%) with BRCA2 mutations and 2 families (13.3%) with BRCA1 mutations. A single variant, BRCA2‐8765delAG, was the most recurrent mutation in the series and was found in 12 of 102 families (11.8%) and in 18 of 657 patients (2.7%). The average age at diagnosis was significantly younger in families with BRCA1/2 mutations (48.6 yrs) compared with the age of patients who had no detectable mutation (52.9 yrs; P = 0.039). Moreover, BRCA1/2 mutations were found at a significantly higher rate in families who had at least 1 member with ovarian carcinoma or male breast carcinoma (5 of 12 families; 41.7%) than in families without such an association (10 of 90 families; 11.1%; P = 0.003).

CONCLUSIONS

BRCA2 mutations were approximately 6 times more prevalent than BRCA1 mutations. A diagnosis of breast carcinoma before age 50 years, ovarian carcinoma, male breast carcinoma, and 3 affected generations all were associated significantly with BRCA1/2 mutations. Although the current findings provided further support for the hypothesis that additional breast carcinoma susceptibility genes remain to be identified, such indicators of the presence of BRCA1/2 mutations may be useful in counseling patients about undergoing genetic testing. Cancer 2005. © 2005 American Cancer Society.
Proton transfer chemical ionization mass spectrometry of fatty acid methyl esters separated by gas chromatography: quantitative aspects
Authors: Dodds Eric D. , McCoy Mark R. , Rea Lorrie D. , Kennish John M.
Published: July 2005

The propensity of esters to accept protons in the gas phase during chemical ionization (CI) mass spectrometry (MS) has been well known for some time. This proton transfer CI almost exclusively produces the [M+H]+ quasimolecular ion for most esters. While it has been suggested that this could serve as the basis for particularly sensitive quantitation of fatty acid methyl esters (FAME) separated by gas chromatography (GC), the application of this approach to quantitate FAME has not been fully explored. Here, we briefly address some considerations pertinent to the application of GC with proton transfer CI‐MS to quantitative analysis of FAME. Limits of detection and relative response factors (RF) for a number of FAME separated by GC and detected by CI‐MS are presented and discussed. While the detection limits are comparable or superior to other detection methods, it was noted that the RF for unsaturated FAME were dramatically reduced with increasing degree of unsaturation.