bluuebunny/crossref_metadata_2025 huggingface dataset:
Big data marketing strategy approaches for businesses selling through online marketplace platforms
Authors:   , Hawcroft Daniel
Published: September 2022

This research presents new empirical findings from an inductive analysis based on a mixed method grounded theory approach. Insights are presented into marketplace selling, marketing strategy and big data decision making using data from fifty-seven online marketplace seller organizations. The findings and subsequent conclusions were developed using a triangulation analysis, consisting of 1,249 forum posts, fifty-five questionnaire responses and five in-depth semi-structured interviews with marketplace sellers combined with the findings in the literature. The original contribution to knowledge of this research is a conceptual model for use in formulating marketing strategy when selling on online marketplaces. The conceptual model overcomes the limitations found in the literature and popular traditional marketing strategy models. The implications of this research span both theoretical and practical domains. The findings in the theoretical domain lead to the proposition that marketplace sellers are entrepreneurs, big data literate, creative, and seek out novel opportunities for products to sell. Sellers rely on big data analysis and research, obtaining market intelligence through the understanding of this data, experimentation, observation, and monitoring in the market. Big data is used to inform both business and marketing strategy, based around the marketing mix, big data is the foundation for key decisions in these areas. In the practical domain, findings showed that organizational capabilities and scale were enabled by the marketplace through their enhanced services and large customer base. Lastly, the selling environment is highly restricted with limited access to the customer, as such the findings show that sellers do not entice customers through “share of voice” or use traditional marketing messaging. Instead, their marketing strategy and leading tactics are to optimize the search rankings and convert a customer from a viewer to a buyer using a virtuous cycle of positive customer experience leading to key trust indicators that customers look for.
Family caregivers’ experiences in the palliative care context: A longitudinal, qualitative study
Authors:   , Dunsmore-Dawson Joan-Anne
Published: September 2022

Caregivers who provide care patients for a family member with terminal illness towards the end of their lives play a key role in the UK health and social care system. This research project aimed to explore the longitudinal experiences of nine family caregivers who were providing care for a family member diagnosed with a terminal illness. A longitudinal qualitative cross-sectional research design drawing on the principles of phenomenology was adopted to explore how and in what ways the family caregivers’ experiences are similar or different to the patients during the time they provide care for the patient. This also considered how the caregivers’ interactions with palliative care services impacted of their experience. Nine family caregivers were recruited from three separate areas of a twelve bedded hospice in Yorkshire. Six participants were interviewed three times and three participants were interviewed twice over a period of one year. Interviews were conducted at different points in each family caregivers’ journey which were identified by them as points which had marked a shift in their perceptions and gave shape to their experience of the phenomena. In total, 24 interviews were conducted which produced a large amount of data. All first second and third interviews were iteratively analysed as a series of stand-alone studies using thematic analysis. Themes within the accounts of individual family caregivers revealed patterns of change and stability shedding light on their unfolding longitudinal experiences. The study offers a number or contributions which add to the body of knowledge relating to family caregivers’ experiences. These pertained to how the practical and emotional support offered to family caregivers across time plays a key role in helping them to adapt to the fluctuating needs of the patient throughout their illness. The crucial role played by palliative care services was seen to be important in their being able to cope with the demands of providing care by helping them to adapt their caring styles according to the fluctuating needs of the patient throughout their illness. An essential element of this support was identified as having consistent and reliable access to support from professionals in palliative care services over the course of the caregiving journey. Inequality in terms of access to financial resources by individual caregivers presented a barrier to the family caregivers which increased the amount of caregiver burden they experienced. Those who are affected by a lack of access to appropriate funding are at greater risk of deterioration in their physical and psychological wellbeing. Support for family caregivers could be strengthened by being delivered according to the needs of the family caregiver over the time they provide care. Tools which assess the family caregivers’ needs should take into account the unique demands of the psychosocial context in which caregiving occurs.
Emprendimiento Internacional en Latinoamérica: Desafíos para el Desarrollo
Authors: Ernesto Amorós José , Etchebarne Soledad , Felzensztein Christian
Published: September 2022

Este estudio analiza de forma exploratoria el fenómeno de las empresas que desde su nacimiento se orientan a los mercados internacionales conocidas como born globals. Para este fin se desarrolla un modelo que integra variables relativas al entorno de la empresa y del emprendedor, con la propensión a la internacionalización en una muestra de emprendedores de países latinoamericanos. Los datos para el análisis se obtuvieron del Global Entrepreneurship Monitor, GEM de los años 2008 y 2009 de 13 países de América Latina y se utilizó un modelo de regresión ordinal (n=4756). Los resultados indican que un 10.8% de los emprendedores tiene una alta propensión a la internacionalización; sin embargo estos emprendimientos no son muy competitivos en términos de innovación (tecnológica y de modelos de negocios) y factores como la competitividad relativa es significativa respecto a la propensión a la internacionalización, pero no así el sector industrial del negocio. Finalmente se discuten las implicaciones prácticas y las investigaciones futuras.
TRIBUNA: Morosidad, solvencia y acceso al crédito de las PYMES en la crisis económica española
Authors: de la Fuente Cabrero Concepción , Laguna Sánchez Mª del Pilar , Villacé Molinero Mª Teresa
Published: September 2022

El objetivo de esta investigación es analizar la evolución del sector de SGR español y los problemas derivados del aumento de la morosidad en el contexto de la actual crisis económica. Entre las principales conclusiones, destacar que ante las mayores dificultades actuales las SGR adquieren mayor relevancia para facilitar el acceso al crédito para las PYMES. Sin embargo, estas sociedades están afectadas igualmente por el aumento de la morosidad y la necesidad de mantener unos ratios de solvencia adecuados, al igual que otras entidades financieras. Se analiza el papel del reafianzamiento para la cobertura del riesgo de crédito de las SGR, así como la solvencia de estas sociedades y los niveles de actividad en estos años. Se pone de manifiesto la importancia de las últimas disposiciones que se han puesto en marcha, como la ponderación del reaval de CERSA a efecto del cálculo del coeficiente de recursos propios, y la implementación de diversos reafianzamientos autonómicos. Estas medidas permiten a las SGR asumir más riesgo y refuerzan su solvencia.
A leap into the future – migrating to FOLIO: A cataloguer’s perspective
Authors: Moonasar Anushie
Published: September 2022

The aim of this paper is to share the journey of the Durban University of Technology (DUT) Library experience as one of the first African libraries to adopt an open-source integrated library management system. It is hoped that other libraries may benefit from this migration experience. The main aim of an Integrated Library System (ILS) is to improve productivity for both users and librarians. The migration from the old library management system to the new system encountered many challenges which included limited time, data corruption and quality issues. The cataloguing section is usually the main focus area that deals with the bulk of the migration data corruption issues. This paper highlights and focuses on a cataloguer’s perception of the new ILS Future of Libraries is Open (FOLIO) and the way the cataloguers adjusted to the new system. Evidence of the migration process was obtained from reports and active participation in the implementation process.
PERCEPCIÓN DE LOS ENFERMEROS FRENTE AL PROCESO DE VACUNACIÓN COVID-19 EN LOS CENTROS DE SALUD FAMILIAR DE LA CIUDAD DE OSORNO (CHILE) DURANTE EL AÑO 2021
Authors:   Facultad de Salud, Universidad Santo Tomás, Osorno (Chile), Olivares Ramírez Gabriela del Pilar , Barrientos Rosas Rocío Belén ,   Facultad de Salud, Universidad Santo Tomás, Osorno (Chile), Feest Arriagada Alexandra Odita ,   Facultad de Salud, Universidad Santo Tomás, Osorno (Chile), Medel Rauque Camila Angelica ,   Facultad de Salud, Universidad Santo Tomás, Osorno (Chile), Peters Sanhueza Pía Catalina ,   Facultad de Salud, Universidad Santo Tomás, Osorno (Chile)
Published: September 2022

El personal de enfermería en el año 2021 se vio estrechamente relacionado con el proceso de vacunación COVID-19. Ya que este estamento se encontraba a cargo de la promoción, gestión y ejecución de la vacunación. Los enfermeros que participaron en la ejecución de la campaña de inmunización contra COVID-19 tienen una mirada interna de lo que significó aquel proceso. Es por esto, que a un grupo de enfermeros de distintos Centros de Salud Familiar de la cuidad de Osorno (Chile) se le aplicó una entrevista para conocer cuál es su percepción frente al proceso de ejecución de la vacunación contra el COVID-19. De esta manera se logró dejar en evidencia este recurso sustancial como la opinión de los actores implicados en el propio proceso, para precisar futuras mejoras en las medidas sanitarias implementadas en la tarea de vacunación e identificar la visión protagónica del equipo de salud en este proceso histórico a nivel mundial. En su elaboración, se utilizó como base los 7 principios éticos propuestos por el autor Ezekiel Emanuel. Los criterios de inclusión para la selección de sujetos fueron enfocadas al personal enfermero que haya participado durante el proceso de vacunación de COVID-19 el año 2021. El instrumento utilizado fue una entrevista con 6 preguntas abiertas, las cuales fueron contestadas en forma online a través de la plataforma Google Drive. El guion de entrevista fue previamente sometido a un proceso de validación de contenido por expertos.
ACTUALIZACION DEL PROGRAMA DE ORIENTACION PARA ENFERMEROS DE LA UNIDAD DE PACIENTE CRÍTICO ADULTO DEL HOSPITAL REGIONAL DE TALCA (CHILE)
Authors:   Escuela de Enfermería, Facultad de Ciencias de la Salud, Universidad Católica del Maule, Talca (Chile), Pavez Avilez Eugenio , Troncoso Valenzuela Bernardita ,   Facultad de Enfermería y Obstetricia, Universidad de los Andes, Santiago (Chile)
Published: September 2022

El Hospital Dr. César Garavagno Burotto también llamado Hospital Regional de Talca (HRT) el año 2010 inició la construcción de las nuevas instalaciones logrando triplicar la dotación llegando a 1468 cargos y 645 camas(1) aumentando consigo la complejidad en la atención del paciente crítico, logrando ser centro de referencia de VI y VII región en trasplante renal y neurocirugía. Estos cambios van de la mano con la necesidad de nuevas contrataciones de enfermeros/as, los cuales deben pasar por un proceso de orientación clínica institucional que no cumple con los estándares requeridos para dicho proceso. El objetivo del proyecto fue actualizar el programa institucional de orientación para enfermeros/as en la unidad de paciente crítico adulto (UPCA) del HRT incorporando la mentoría clínica y pautas de evaluación, teniendo como resultado un programa basado en evidencia, con metas claras, evaluación clínica objetiva, ajustado a la realidad local y fomentando el análisis crítico. Se realizaron encuestas a funcionarios con 5 o más años de experiencia, usando el método Delphi, en la UPCA HRT, para determinar cuáles son las competencias clínicas que debería adquirir el novato enfermero o enfermera según la subunidad en que se desarrolle, este resultado se complementa con información epidemiológica local de las patologías más comunes en dicha unidad, se tabula la información y se confecciona una rúbrica con resultados de aprendizaje, los cuales serán evaluados en el programa de mentoría
Neutrophil-lymphocyte Ratio as Independent Prognostic Factor among Breast Cancer Patients in a Tertiary Care Hospital, Kolkata, India
Authors: Mayur Nabanita , Roy Anup Kumar , Banik Lahari
Published: September 2022

Introduction: The most important prognostic factor for breast cancer is tumour stage and tumour grade. However, the assessment of the above parameters are time-consuming and require expertise. Thus evaluation of the prognosis of breast cancer is still limited to tertiary care hospitals, with appropriate facilities for histopathological techniques. Recently, inflammatory blood markers have shown a role as a prognostic factor. Out of all the inflammatory blood markers, neutrophil-lymphocyte ratio has emerged as the most useful. Abundant evidence suggests the role of NLR as an adverse prognostic factor in breast cancer. NLR is simple and inexpensive. It can be easily obtained, as the differential count of every patient is done routinely. Thus it can act as an indicator of high-risk patients who are likely to show poor prognosis. Though NLR has been found to play a role in prognosis prediction in breast cancer, much is unknown in this field. Aim: To assess the effectiveness of Neutrophil-Lymphocyte Ratio (NLR) as an independent prognostic parameter among breast cancer patients in a tertiary care hospital in Kolkata, India. Materials and Methods: This observational cross-sectional study was conducted in Department of Pathology, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India, where 140 female patients undergoing mastectomy for breast cancer were studied from 1st February 2019 to 31st January 2020. The clinicopathological parameters, histopathological parameters, and molecular subtypes were evaluated. NLR was calculated and related with the other prognostic parameters. Data entry was done in Microsoft Excel and analysis was done using Statistical Package for Social Sciences (SPSS) software version 20.0. One way Analysis of Variance (ANOVA) test and Chi-square test was conducted to assess the relationship of NLR with various other prognostic factors. Results: Out of 140 patients, 78 patients showed NLR values within 1.8 to 3.33. Higher NLR (>3.33) was associated with poor prognostic factors like higher T stage (T4) {17 (53.1%)}, higher stage (stage III) 95 (67.8%), skin involvement 19 (47.5%), Lymphovascular involvement in 23 (39.7%), perineural involvement in 10 (71.4%) and in patients with HER2 positive molecular subtype in 8 (5.7%). Conclusion: This study suggests that a high NLR value was associated with poor prognosis in breast cancer patients. Thus, it can be used as an independent marker of poor prognosis and can help guide the treatment of breast cancer patients. The more we study the role of NLR, the more useful it will be in predicting the course of breast cancer as early as possible.
Performance Assessment of Principal Component Analysis and Kernel Principal Component Analysis Using TOAM Database
Authors: Niyi Madandola, Tajudeen , Alagbe Gbolagade, Kazeem , Wuraola Yusuf-Asaju Ayisat
Published: September 2022

Face recognition algorithms can be classified into appearance-based (Linear and Non-Linear Appearance-based) and Model-based Algorithms. Principal Component Analysis (PCA) is an example of Linear Appearance-based which performs a linear dimension reduction while Kernel Principal Component Analysis (KPCA) is an example of non-linear appearance methods. The study focuses on the performance assessment of PCA and KPCA face recognition techniques. The assessment is carried out base on computational time using testing time and recognition accuracy on created database identified as TOAM database. The created database is mainly for this research purpose and it contains 120 face images of 40 persons frontal faces with 3 images of each individual under different lighting, facial expressions, occulations, environment and time. The findings reveal an average testing Time of 1.5475 seconds for PCA and 67.0929 seconds for KPCA indicating a longer Computational time for KPCA than PCA. It also reveals that PCA has 72.5% performance recognition accuracy while KPCA has 80.0% performance recognition accuracy indicating that KPCA outperforms the PCA in terms of recognition accuracy.
Mulheres na Política: Uma revisão sistemática
Authors: Teixeira Marcella Barbosa Miranda , Mota-Santos Carolina Maria
Published: September 2022

O objetivo desta revisão sistemática foi analisar a literatura sobre mulheres na política, de maneira a identificar lacunas e oportunidades de pesquisa dessa temática para a área de Administração. A busca por artigos foi realizada nas bases de periódicos Capes, Scielo e Spell, entre os anos de 2014 a 2019, na qual foram selecionados 38 artigos, de acordo com critérios de classificação. Para a análise dos artigos, dividiu-os em quatro categorias, conforme a abordagem deles: participação e (sub) representação de mulheres na política; ações afirmativas para mulheres na política; mulheres na política: liderança e voto feminino; mulheres na política na área de comunicação. Como resultado, verificou-se que a temática ainda é incipiente na produção acadêmica nacional na área de administração, sendo necessária maior atenção para o tema.
Experiências de mulheres lésbicas e atitudes de profissionais de enfermagem nos serviços de saúde:
Authors: Milanez Letícia de Sousa , Ferreira Luís Felipe Oliveira , Lima Francisco Renato , Silva Adriane das Neves , Ferreira Breno de Oliveira , Nabero Ana Paula Pereira , Pedrosa José Ivo dos Santos
Published: September 2022

Buscou-se investigar as atitudes de profissionais de enfermagem frente aos cuidados voltados às mulheres lésbicas e as experiências vivenciadas por estas nos serviços de saúde, apoiadas na literatura nacional e internacional, além de construir uma síntese interpretativa da literatura à luz de Bourdieu. Trata-se de uma revisão integrativa da literatura, cuja amostra de 40 artigos foi selecionada nas bases PubMed, Scopus, LILACS e BDENF, no período entre 2004 e 2021. A literatura estudada mostra que as mulheres lésbicas vivenciaram experiências de preconceito, estigmatização e ansiedade nos serviços de saúde. Aponta ainda, que o habitus heteronormativo, fortemente presente nas práticas de saúde, promovem cuidados de enfermagem, em sua maioria, distorcidos, voltados para as mulheres lésbicas como se elas fossem heterossexuais, seja nas dimensões institucionais, relacionais e/ou símbolicas dos serviços de saúde. Desse modo, é necessário garantir a formação em serviço para profissionais de enfermagem, a fim de incluir e naturalizar as particularidades e demandas das mulheres lésbicas.
Entre a performance e a performatividade
Authors: Gusmão Roney
Published: September 2022

Neste texto o autor se interessa em problematizar o gênero pelo campo da memória social, levando em consideração as proximidades inevitáveis entre os conceitos de performance e performatividade. A memória insurge neste processo como força de permanência pelos referenciais de legibilidade, mas, também como força subversiva na medida que se impõe como ato criativo. Assim, pensar a performance e a performatividade de gênero requer levar em consideração os referenciais guardados na memória e também por ela subvertidos.
Atravessamentos que constituem a compreensão da infertilidade em homens:
Authors: Souza Ana Flavia de , Souza Janine Gudolle de , Roso Adriane
Published: September 2022

A infertilidade tem sido considerada um problema de saúde pública e condição enfrentada por diversas pessoas no mundo. A presente revisão teve como objetivo investigar os fatores: estilo de vida, modelos de masculinidades e atenção à saúde sexual e reprodutiva de homens com infertilidade. Para tanto, foi realizada uma revisão integrativa de 24 artigos científicos revisados por pares. Os resultados foram organizados a partir de três categorias de análise: interferências de fatores genéticos, ambientais e estilo de vida na infertilidade em homens; impactos do modelo de masculinidade hegemônica em homens inférteis; problemas enfrentados na atenção à saúde sexual e reprodutiva de homens. Tais resultados indicam o quanto a infertilidade em homens ainda é compreendida por uma visão biologicista e médica, atravessada por mitos e estereótipos. As masculinidades interferem nas representações sociais sobre a infertilidade em homens, a qual primeiramente é vista como ligada às mulheres e não aos homens. Os serviços de saúde ainda possuem barreiras no que se refere ao atendimento no campo da saúde sexual e reprodutiva de homens, particularmente porque os homens ainda apresentam resistência para cuidar de sua saúde preventivamente.
Dos baphos babadeiros de gênero, sexualidade e saúde
Authors: Duque Tiago , Oliveira Esmael Alves de , Costa Patrícia Rosalba Salvador Moura
Published: September 2022

Não se aplica
Corneal Wound Associated With Orthokeratology Lenses
Authors: Liu Chang , Ni Yao
Published: September 2022

This case report describes a diagnosis of corneal epithelial defect after a patient presentation of eye pain and tearing with orthokeratology lens wear.
Treatment-Refractory Nodular Scleritis
Authors: Francis Jasmine H. , Gobin Y. Pierre , Diamond Eli L.
Published: September 2022

A 59-year-old woman with a 5-year history of intermittent bilateral uveitis and scleritis presented with painful left uveitis and an episcleral nodule shown to be a uveal-episcleral lesion on ultrasound biomicroscopy. Biopsy of a nasal sinus mass 3 years earlier showed a histiocytic infiltrate with emperipolesis, consistent with Rosai-Dorfman-Destombes disease. What would you do next?
Super‐resolution of brain tumor MRI images based on deep learning
Authors: Zhou Zhiyi , Ma Anbang , Feng Qiuting , Wang Ran , Cheng Lilin , Chen Xin , Yang Xi , Liao Keman , Miao Yifeng , Qiu Yongming
Published: September 2022

Introduction

To explore and evaluate the performance of MRI‐based brain tumor super‐resolution generative adversarial network (MRBT‐SR‐GAN) for improving the MRI image resolution in brain tumors.

Methods

A total of 237 patients from December 2018 and April 2020 with T2‐fluid attenuated inversion recovery (FLAIR) MR images (one image per patient) were included in the present research to form the super‐resolution MR dataset. The MRBT‐SR‐GAN was modified from the enhanced super‐resolution generative adversarial networks (ESRGAN) architecture, which could effectively recover high‐resolution MRI images while retaining the quality of the images. The T2‐FLAIR images from the brain tumor segmentation (BRATS) dataset were used to evaluate the performance of MRBT‐SR‐GAN contributed to the BRATS task.

Results

The super‐resolution T2‐FLAIR images yielded a 0.062 dice ratio improvement from 0.724 to 0.786 compared with the original low‐resolution T2‐FLAIR images, indicating the robustness of MRBT‐SR‐GAN in providing more substantial supervision for intensity consistency and texture recovery of the MRI images. The MRBT‐SR‐GAN was also modified and generalized to perform slice interpolation and other tasks.

Conclusions

MRBT‐SR‐GAN exhibited great potential in the early detection and accurate evaluation of the recurrence and prognosis of brain tumors, which could be employed in brain tumor surgery planning and navigation. In addition, this technique renders precise radiotherapy possible. The design paradigm of the MRBT‐SR‐GAN neural network may be applied for medical image super‐resolution in other diseases with different modalities as well.
Metal–Organic Frameworks and Their Composites for Environmental Applications
Authors: Zhang Qian , Yang Hui , Zhou Ting , Chen Xudong , Li Wenting , Pang Huan
Published: September 2022

From the point of view of the ecological environment, contaminants such as heavy metal ions or toxic gases have caused harmful impacts on the environment and human health, and overcoming these adverse effects remains a serious and important task. Very recent, highly crystalline porous metal–organic frameworks (MOFs), with tailorable chemistry and excellent chemical stability, have shown promising properties in the field of removing various hazardous pollutants. This review concentrates on the recent progress of MOFs and MOF‐based materials and their exploit in environmental applications, mainly including water treatment and gas storage and separation. Finally, challenges and trends of MOFs and MOF‐based materials for future developments are discussed and explored.
Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l‐lactate transport in the hepatocellular carcinoma cell line
Authors: Mukai Yuto , Yamaguchi Atsushi , Sakuma Tomoya , Nadai Takanobu , Furugen Ayako , Narumi Katsuya , Kobayashi Masaki
Published: September 2022

Fourteen isoforms of the monocarboxylate transporter (MCT) have been reported. Among the MCT isoforms, MCT1, MCT2, and MCT4 play a role in l‐lactate/proton cotransport and are involved in the balance of intracellular energy and pH. Therefore, MCT1, MCT2, and MCT4 are associated with energy metabolism processes in normal and pathological cells. In the present study, we evaluated the expression of MCT1, MCT2, and MCT4 and the contribution of these three MCT isoforms to l‐lactate uptake in hepatocellular carcinoma (HCC) cells. In HepG2 and Huh‐7 cells, l‐lactate transport was pH‐dependent, which is characteristic of MCT1, MCT2, and MCT4. Furthermore, l‐lactate uptake was selectively inhibited by MCT1 and MCT4 inhibitors in HepG2 and Huh‐7 cells. Kinetic analysis of HepG2 cells demonstrated that l‐lactate uptake was biphasic. Although the knockdown of MCT1 and MCT4 in the HepG2 cells decreased the uptake of l‐lactate, the knockdown of MCT2 had no effect on the uptake of l‐lactate. Consequently, we concluded that both MCT1 and MCT4 were involved in the transport of l‐lactate in HepG2 and Huh‐7 cells at pH 6.0. In contrast, PXB‐cells, freshly isolated hepatocytes from humanized mouse livers, showed lower MCT4 expression and l‐lactate uptake at pH 6.0 compared to that in HCC cell lines. In conclusion, MCT4, which contributes to l‐lactate transport in HCC cells, is significantly different in HCC compared to normal hepatocytes, and has potential as a target for HCC treatment.
Synthesis of the C1‐C18 fragment of Neaumycin B
Authors: Pyun Yu Mi , In Cho Su , Lee Seung Ju , Lee Duck Hyung
Published: September 2022

Stereoselective synthesis of the C1–C18 fragment 2 of Neaumycin B (1), 28‐membered macrolide compound with 19‐chiral centers and 6,6‐spiroketal structure, has been described. Brown syn‐crotylation and olefin metathesis reaction were used as key steps from (R)‐roche ester in the synthesis of C8–C18 fragment 3. C1–C7 fragment 4 was constructed from 1,3‐propanediol using diastereoselective allylation, syn‐aldol reaction, and olefin metathesis reaction as key steps. Finally, NHK reaction and (S)‐CBS reduction as key steps led to the of synthesis of C1–C18 fragment 2 of Neaumycin B (1).
Shape analysis of subcortical structures in obsessive‐compulsive disorder and the relationship with comorbid anxiety, depression, and medication use: A meta‐analysis by the OCD Brain Imaging Consortium
Authors: Fouche Jean‐Paul , Groenewold Nynke A. , Sevenoaks Tatum , Heany Sarah , Lochner Christine , Alonso Pino , Batistuzzo Marcelo C. , Cardoner Narcis , Ching Christopher R. K. , de Wit Stella J. , Gutman Boris , Hoexter Marcelo Q. , Jahanshad Neda , Kim Minah , Kwon Jun Soo , Mataix‐Cols David , Menchon Jose M. , Miguel Euripedes C. , Nakamae Takashi , Phillips Mary L. , Pujol Jesus , Sakai Yuki , Yun Je‐Yeon , Soriano‐Mas Carles , Thompson Paul M. , Yamada Kei , Veltman Dick J. , van den Heuvel Odile A. , Stein Dan J.
Published: September 2022

Objective

Neuroimaging studies of obsessive‐compulsive disorder (OCD) patients have highlighted the important role of deep gray matter structures. Less work has however focused on subcortical shape in OCD patients.

Methods

Here we pooled brain MRI scans from 412 OCD patients and 368 controls to perform a meta‐analysis utilizing the ENIGMA‐Shape protocol. In addition, we investigated modulating effects of medication status, comorbid anxiety or depression, and disease duration on subcortical shape.

Results

There was no significant difference in shape thickness or surface area between OCD patients and healthy controls. For the subgroup analyses, OCD patients with comorbid depression or anxiety had lower thickness of the hippocampus and caudate nucleus and higher thickness of the putamen and pallidum compared to controls. OCD patients with comorbid depression had lower shape surface area in the thalamus, caudate nucleus, putamen, hippocampus, and nucleus accumbens and higher shape surface area in the pallidum. OCD patients with comorbid anxiety had lower shape surface area in the putamen and the left caudate nucleus and higher shape surface area in the pallidum and the right caudate nucleus. Further, OCD patients on medication had lower shape thickness of the putamen, thalamus, and hippocampus and higher thickness of the pallidum and caudate nucleus, as well as lower shape surface area in the hippocampus and amygdala and higher surface area in the putamen, pallidum, and caudate nucleus compared to controls. There were no significant differences between OCD patients without co‐morbid anxiety and/or depression and healthy controls on shape measures. In addition, there were also no significant differences between OCD patients not using medication and healthy controls.

Conclusions

The findings here are partly consistent with prior work on brain volumes in OCD, insofar as they emphasize that alterations in subcortical brain morphology are associated with comorbidity and medication status. Further work is needed to understand the biological processes contributing to subcortical shape.
Mortality after the 9/11 terrorist attacks among world trade center health registry enrollees with cancer
Authors: Kehm Rebecca D. , Li Jiehui , Takemoto Erin , Yung Janette , Qiao Baozhen , Farfel Mark R. , Cone James E.
Published: September 2022

Background

While several studies have reported the association between 9/11 exposure and cancer risk, cancer survival has not been well studied in the World Trade Center (WTC) exposed population. We examined associations of 9/11‐related exposures with mortality in WTC Health Registry enrollees diagnosed with cancer before and after 9/11/2001.

Patients and Methods

This is a longitudinal cohort study of 5061 enrollees with a first‐ever primary invasive cancer diagnosis between 1995 and 2015 and followed through 2016. Based on the timing of first cancer diagnosis, pre‐9/11 (n = 634) and post‐9/11 (n = 4427) cancer groups were examined separately. 9/11‐related exposures included witnessing traumatic events, injury on 9/11, and 9/11‐related post‐traumatic stress disorder (PTSD). Associations of exposures with all‐cause mortality were examined using Cox proportional hazards regression. In the post‐9/11 group, cancer‐specific mortality was evaluated by enrollee group (WTC rescue/recovery workers vs. non‐workers) using Fine and Gray's proportional sub‐distribution hazard models, adjusting for baseline covariates, tumor characteristics, and treatment.

Results

In the pre‐9/11 group, 9/11‐related exposures were not associated with all‐cause mortality. In the post‐9/11 group, increased risk of all‐cause mortality was associated with PTSD (adjusted HR = 1.35; 95% CI = 1.11–1.65), but not with injury or witnessing traumatic events. Cancer‐specific mortality was not statistically significantly associated with 9/11‐related exposures. In rescue/recovery workers, increased non‐cancer mortality risk was associated with PTSD (aHR = 2.13, 95% CI = 1.13–4.00) and witnessing ≥3 traumatic events (aHR = 2.00, 95% CI = 1.13–3.55).

Conclusions

We did not observe associations between 9/11‐related exposures and cancer‐specific mortality. Similar to findings in the non‐cancer WTC exposed population, PTSD was associated with increased risk of all‐cause mortality in cancer patients.
Partner with legal counsel to navigate compliance issues
Authors: McCarthy Claudine
Published: September 2022

LAS VEGAS — Compliance administrators can more effectively navigate the ongoing changes in college athletics by building partnerships with legal counsel. That's according to a panel of legal and compliance professionals who spoke at the annual convention for the National Association for Athletics Compliance. The panel was moderated by Todd Vardaman, Senior Associate Athletic Director for Administration at the University of North Alabama.
Xanthogranulomatous hypophysitis: A rare presentation in a young female patient
Authors: Yaghoubi Mohammad Ali , Zabihyan Samira , Saeidinia Amin , Gharib Masoumeh , Ghiyasi Moghaddam Ramin
Published: September 2022

Hypophysitis is a rare inflammatory condition that may present both clinically and radiologically as a neoplastic lesion. Xanthogranulomas are rare intracranial lesions with controversial etiology. Here, we report a clinical case of histologically confirmed xanthogranulomatosis hypophysitis in a young female with type I diabetes mellitus and hypothyroidism.
Neuromeningeal cryptococcosis in a patient not infected with human immunodeficiency virus and without known risk factors: A case report
Authors: Andrianiaina Armel Mamihaja , Randrianarisoa Rova Malala Fandresena , Ratsimbazafy Solohery Jean Noel , Rakotonirina Lalao Nomenjanahary , Vololontiana Hanta Marie Danielle
Published: September 2022

We report a 24‐year‐old female patient not infected with human immunodeficiency virus (HIV) and without other risk factors of immunosuppression, presenting with neuromeningeal cryptococcosis. Cerebrospinal fluid (CSF) analysis revealed the presence of Cryptococcus neoformans. The evolution was unfavorable and the patient died even after appropriate antifungal treatment.
An Easy‐to‐Use Custom‐Built Cell for Neutron Powder Diffraction Studies of Rechargeable Batteries
Authors: Risskov Sørensen Daniel , Østergaard Drejer Andreas , Heere Michael , Senyshyn Anatoliy , Frontzek Matthias , Hansen Thomas , Didier Christophe , Peterson Vanessa K. , Bomholdt Ravnsbæk Dorthe , Ry Vogel Jørgensen Mads
Published: September 2022

In operando powder diffraction remains one of the most powerful tools for non‐destructive investigation of battery electrode materials. While in operando X‐ray, especially synchrotron radiation, powder diffraction is by now a routine experimental technique, in operando neutron powder diffraction is still less established. We present a new electrochemical cell for in operando neutron powder diffraction, which is, first and foremost, easy to use, but can also cycle electrode materials under electrochemical conditions close to those achieved using standard laboratory cells. The cell has been designed in multiple sizes, and high‐quality electrochemical and neutron powder diffraction data is presented for sample sizes as low as 48 mg total active material. The cell handles lithium‐ion and sodium‐ion materials equally well, with no difference in how the cell is prepared and assembled. The cell is intended to be used as sample environment at powder diffractometers at the neutron facilities MLZ, ORNL and ACNS.
Decadal and seasonal changes in landcover at Padre Island: Implications for the role of the back‐barrier in signaling island state change
Authors: Fisher Kenton R. , Ewing Ryan C. , Duran Vinent Orencio
Published: September 2022

Long‐term and seasonal geomorphological changes at Padre Island, Texas are identified and linked with potential external drivers. Aerial and satellite images from 1950 to 2018, monthly images from 2019 to 2020, and a 2018 LiDAR data set are used to assess long‐term and seasonal geomorphological changes within a 50 km2 area of Padre Island near Port Mansfield, Texas. Trends in landcover are evaluated by mapping and comparing the relative areal coverage of each facies. Vegetated dunes, absent initially, emerged in the fore‐island and expanded into the back‐barrier to cover 14% of the study area. The active vegetation‐free back‐barrier dune field steadily decreased in areal extent from 12% to 6% as vegetation spread. Nebkha dune coverage fluctuated between 4% and 7%. Expansive microbial mats colonized the wind tidal and deflation flats surrounding the vegetated dunes and back‐barrier dune field giving rise to a remarkably different landscape over the 50‐year period studied. An assessment of external forcing factors identifies increased rates of relative sea level rise and decreased sediment influx as the most likely primary factors driving the geomorphological changes. These changes have induced a widespread shift toward stabilization of island sediments by vegetation and microbial mats, which in turn has starved the back‐barrier of sediments resulting in low rates of accretion and increased flooding. These findings highlight the sensitivity of the back‐barrier and, in particular, the dune facies to changes in sea level and sediment supply, and show that microbial mats are effective at stabilizing island sediments and may be harbingers to barrier island response to rising sea level. As shown in this study, long‐term monitoring of geomorphic facies changes and topography can detect important shifts in the island state that can be used to inform decision making for these sensitive coastal landscapes.
Memory optimization at Edge for Distributed Convolution Neural Network
Authors: Naveen Soumyalatha , Kounte Manjunath R.
Published: September 2022

Internet of Things (IoT) edge intelligence has emerged by optimizing the deep learning (DL) models deployed on resource‐constraint devices for quick decision‐making. In addition, edge intelligence reduces network overload and latency by bringing intelligent analytics closer to the source. On the other hand, DL models need a lot of computing resources. As a result, they have high computational workloads and memory footprint, making it impractical to deploy and execute on IoT edge devices with limited capabilities. In addition, existing layer‐based partitioning methods generate many intermediate results, resulting in a huge memory footprint. In this article, we propose a framework to provide a comprehensive solution that enables the deployment of convolutional neural networks (CNNs) onto distributed IoT devices for faster inference and reduced memory footprint. This framework considers a pretrained YOLOv2 model, and a weight pruning technique is applied to the pre‐trained model to reduce the number of non‐contributing parameters. We use the fused layer partitioning method to vertically partition the fused layers of the CNN and then distribute the partition among the edge devices to process the input. In our experiment, we have considered multiple Raspberry Pi as edge devices. Raspberry Pi with a neural computing stick is a gateway device to combine the results from various edge devices and get the final output. Our proposed model achieved inference latency of 5 to7 seconds fortofused layer partitioning for five devices with a 9% improvement in memory footprint.
Can soy isoflavones in combination with soy protein change serum concentration of adiponectin and resistin? A systematic review and meta‐analysis on randomized clinical trials
Authors: Hariri Mitra , Amirkalali Bahareh , Mollanoroozy Ensiyeh , Gholami Ali
Published: September 2022

Some studies proposed the anti‐inflammatory effect of soy protein and soy isoflavones by changing the serum adiponectin and resistin levels. The purpose of this research was to determine the impact of soy isoflavones and soy protein on blood adiponectin and resistin levels in adults. Scopus, PubMed, Cochrane Library, ISI Web of Science, and ClinicalTrials.gov databases were searched until April 2022. The effect size was computed by the mean changes from the beginning for intervention and comparison groups and their standard deviation. In the case of significant heterogeneity, DerSimonian and Laird random‐effects model was used. Six and five clinical trials were selected for the systematic review and meta‐analysis, respectively. The overall estimate indicated that soy isoflavones in combination with soy protein did not significantly change serum adiponectin level (weighted mean differences (WMD) = 0.36 μg/ml; 95% confidence interval (CI): −0.26, 0.99; p = .25), but significantly increased serum resistin level (WMD = 0.64 ng/ml, 95% CI: 0.25, 1.04; p = .001). In combination with soy protein, soy isoflavones nonsignificantly increased serum adiponectin levels, but significantly increased resistin levels. New intervention studies with a high dose of soy isoflavones and soy protein in different parts of the world and an updated meta‐analysis are needed to confirm the results of our study.
Inulin‐type fructans and short‐chain fructooligosaccharides—their role within the food industry as fat and sugar replacers and texture modifiers—what needs to be considered!
Authors: Jackson Peter Philip James , Wijeyesekera Anisha , Rastall Robert Adrian
Published: September 2022

Inulin and oligofructose are classes of prebiotics belonging to a group of nondigestible carbohydrates referred to as inulin‐type fructans. While short‐chain fructooligosaccharides are enzymatically synthesized from the hydrolysis and transglycosylation of sucrose. Inulin‐type fructans and short‐chain fructooligosaccharides act as carbon sources for selective pathways supporting digestive health including altering the composition of the gut microbiota along with improving transit time. Due to their physicochemical properties, inulin‐type fructans and short‐chain fructooligosaccharides have been widely used in the food industry as partial replacements for both fat and sugar. Yet, levels of replacement need to be carefully considered as it may result in changes to physical and sensory properties that could be detected by consumers. Furthermore, it has been reported depending on the processing parameters used during production that inulin‐type fructans and short‐chain fructooligosaccharides may or may not undergo structural alterations. Therefore, this paper reviews the role of inulin‐type fructans and short‐chain fructooligosaccharides within the food industry as fat and sugar replacers and texture modifiers, their impact on final sensory properties, and to what degree processing parameters are likely to impact their functional properties.
A combination of modified atmosphere packaging and two chemical disinfectants: Effects on microbial, sensory, and physicochemical properties of raw ready‐to‐eat leek
Authors: Hosseininezhad Behnam , Nader Marzieh , Ramezanian Asghar , Niakousari Mehrdad , Mazloomi Seyed Mohammad
Published: September 2022

In the present study, the effect of modified atmosphere packaging (MAP) on microbial (total aerobic count, yeasts and molds, Enterobacteriaceae, psychrotrophic bacteria, and lactic acid bacteria), physicochemical (pH, moisture content, and color), and sensory properties of raw ready‐to‐eat leek was investigated after disinfection using Percidin–Nanosil disinfectants. There were six different treatments, of which four samples were packaged as MAP (T1 to T4) and two samples were packaged as non‐MAP (T5 and T6). The highest and the lowest reduction in the number of microorganisms after disinfection was observed in psychrotrophic bacteria and total aerobic count, respectively. The count of microbial variables in T2 sample (87% N2, 3% CO2, and 10% O2) was lower than in other treatments. No significant difference was observed in the physcochemical properties (moisture and pH) of treated samples except for the color of T6 sample (cling film) compared to other treatments (p < .05). It is noteworthy that the panelists did not recognize differences among T1, T2, and T5 samples. However, T2 treatment was effective in maintaining microbial, physicochemical, and sensory properties of leek compared to the other treatments. Also, T6 sample showed the lowest quality in all parameters. Disinfection combined with MAP was able to maintain the physicochemical, microbial, and sensory properties of raw ready‐to‐eat leek during storage.
Danshensu attenuated lipopolysaccharide‐induced LX‐2 and T6 cells activation through regulation of ferroptosis
Authors: Wang Changting , Su Zhiming , Xu Jian‐Hua , Ko Chih‐Yuan
Published: September 2022

Liver fibrosis and cirrhosis are primarily caused by the activation of hepatic stellate cells (HSCs), regardless of their etiology. Collagen type I (collagen I) and connective tissue growth factor (CTGF) is produced more readily by activated HSCs. Consequently, identifying the molecular and cellular mechanisms responsible for HSCs activation is essential to better understand its mechanism of action and therapeutic potential. Cell death is caused by iron‐dependent lipid peroxidation during ferroptosis. Ferroptosis plays an important role in the survival of activated HSCs and could contribute to the development of innovative prevention and treatment strategies for liver fibrosis. Danshensu (Dan) is a pure molecule extracted from the Salvia miltiorrhiza herb that protects against liver damage. However, Dan's effect on attenuating HSCs activation by regulating ferroptosis remains unclear. The results of this study indicated that lipopolysaccharide (LPS)‐induced LX‐2 and T6 cells activation occurs through the upregulation of collagen I, CTGF, Gpx4, and SLC7A11. Interestingly, Dan attenuated LPS‐induced liver fibrosis in those cells by upregulating collagen I, CTGF, Gpx4, and SLC7A11 and by increasing lipid reactive oxygen species accumulation. Furthermore, the results also showed that the ferroptosis inhibitor liproxstatin attenuated the overproduction of lipid reactive oxygen species in LPS‐activated LX‐2 cells. We conclude that Dan attenuates LPS‐induced HSC activation during liver fibrosis by regulating ferroptosis in LX‐2 and T6 cells.