bluuebunny/crossref_metadata_2025 huggingface dataset:
Los ‘telares de rejilla o lizo de marco’ en época romana. A propósito de un hallazgo en contexto en Augusta Emerita (Mérida, España)
Authors: Bustamante Álvarez Macarena , Morgado-Roncal Leyre , Murciano Calles José María , Sabio González Rafael , García-Moreno Carlos D.
Published: February 2024

Los telares constituyen uno de los principales instrumentos para la producción textil en la Antigüedad. No obstante, su localización en el registro arqueológico es escasa y limitada. Los telares verticales de pesas son la tipología más conocida, pero no la única. Excepcionalmente, se encuentran en el registro arqueológico evidencias materiales de telares de bandas para el desarrollo de estrechas cenefas que, por lo general, presentan ricas decoraciones. Una de las principales problemáticas ha sido la identificación de estas piezas, la definición de su funcionalidad textil y la confusión existente entre los distintos tipos de telares de bandas. En consecuencia, no solo son difíciles de encontrar arqueológicamente, sino que a menudo no han sido reconocidas como instrumental textil. En este trabajo, aportamos un acercamiento a la tecnología de los telares de bandas en Hispania a partir de un nuevo hallazgo: un telar de rejilla o lizo de marco procedente de un contexto funerario recientemente intervenido en Augusta Emerita (Mérida, Badajoz). Además del análisis de la pieza, planteamos un estudio contextual que permita hacer apreciaciones cronológicas. A ello se le une el estudio antropológico del difunto varón. Esto nos ayuda a plantear y discutir interesantes apreciaciones de género respecto a la configuración social del artesanado textil. Del mismo modo, recogemos un estado actual de la cuestión sobre la tecnología del telar de lizo de marco gracias a una revisión de todas las evidencias encontradas hasta la fecha a lo largo del Imperio. Con este artículo, esperamos ahondar en este tipo de tecnologías textiles, visibilizarlas y dar a conocer su materialización en el registro arqueológico.
Un thymiaterion cerámico de la necrópolis ibérica de Alarcos III (Poblete, Ciudad Real): el perfume y su uso ritual en el ámbito oretano
Authors: Rodríguez-Rabadán Díaz-Cano Miguel Ángel , Miguel-Naranjo Pedro
Published: February 2024

En este trabajo abordamos de manera monográfica el contexto arqueológico de la tumba 45 de la necrópolis ibérica III de Alarcos, actualmente en proceso de excavación y de estudio. La tumba, adscrita a un individuo adulto posiblemente masculino, presenta como parte del ajuar un thymiaterion cerámico inédito compuesto por dos piezas: un soporte calado en su parte inferior y una cazoleta con asa y base perforada. Los paralelos formales que presenta con diferentes soportes calados del oppidum oretano del Cerro de las Cabezas (Valdepeñas, Ciudad Real) y la relación que mantiene la tumba 45 con otros contextos funerarios cercanos permiten datar la tumba entre los siglos IV y III a. C. En este estudio rastreamos los diferentes paralelos de las dos piezas que componen el thymiaterion cerámico en el contexto de la Oretania, así como los thymiateria de bronce y los pebeteros de terracota, y contrastamos si pueden clasificarse o no como posibles quemadores de perfumes. Por otro lado, analizamos el registro arqueológico de los yacimientos oretanos para documentar el empleo del perfume en la zona de estudio, analizando las diferentes tipologías de ungüentarios cerámicos, pasta vítrea y fayenza. Así, hemos podido atestiguar que, desde el siglo VI a. C. hasta época iberorromana, en la mayor parte de los casos el perfume aparece asociado a un uso cultual o funerario del mismo. Finalmente, un análisis detallado del registro material permite relacionar la combustión y el uso de aceites perfumados con el culto a una divinidad femenina relacionada con la fertilidad, la abundancia y la regeneración del ciclo vital.
Predicting Risk of Colorectal Cancer After Adenoma Removal in a Large Community-Based Setting
Authors: Lee Jeffrey K. , Jensen Christopher D. , Udaltsova Natalia , Zheng Yingye , Levin Theodore R. , Chubak Jessica , Kamineni Aruna , Halm Ethan A. , Skinner Celette S. , Schottinger Joanne E. , Ghai Nirupa R. , Burnett-Hartman Andrea , Issaka Rachel , Corley Douglas A.
Published: February 2024

INTRODUCTION:

Colonoscopy surveillance guidelines categorize individuals as high or low risk for future colorectal cancer (CRC) based primarily on their prior polyp characteristics, but this approach is imprecise, and consideration of other risk factors may improve postpolypectomy risk stratification.

METHODS:

Among patients who underwent a baseline colonoscopy with removal of a conventional adenoma in 2004–2016, we compared the performance for postpolypectomy CRC risk prediction (through 2020) of a comprehensive model featuring patient age, diabetes diagnosis, and baseline colonoscopy indication and prior polyp findings (i.e., adenoma with advanced histology, polyp size ≥10 mm, and sessile serrated adenoma or traditional serrated adenoma) with a polyp model featuring only polyp findings. Models were developed using Cox regression. Performance was assessed using area under the receiver operating characteristic curve (AUC) and calibration by the Hosmer-Lemeshow goodness-of-fit test.

RESULTS:

Among 95,001 patients randomly divided 70:30 into model development (n = 66,500) and internal validation cohorts (n = 28,501), 495 CRC were subsequently diagnosed; 354 in the development cohort and 141 in the validation cohort. Models demonstrated adequate calibration, and the comprehensive model demonstrated superior predictive performance to the polyp model in the development cohort (AUC 0.71, 95% confidence interval [CI] 0.68–0.74 vs AUC 0.61, 95% CI 0.58–0.64, respectively) and validation cohort (AUC 0.70, 95% CI 0.65–0.75 vs AUC 0.62, 95% CI 0.57–0.67, respectively).

DISCUSSION:

A comprehensive CRC risk prediction model featuring patient age, diabetes diagnosis, and baseline colonoscopy indication and polyp findings was more accurate at predicting postpolypectomy CRC diagnosis than a model based on polyp findings alone.
La recepción del cristianismo de Thomas Hobbes. La Cristología hobbesiana como causa de su descrédito
Authors: Vargas Jorge Alfonso
Published: February 2024

El artículo analiza la cristología de Thomas Hobbes con el propósito de entender una de las principales causas de su descrito como un pensador cristiano o, incluso, ateo, lo que afecta eventualmente la validez de su teología política. El autor sostiene que si bien Hobbes hace uso de la Biblia como fundamento de su filosofía política, su recepción del cristianismo en general no es enteramente correcta, debido a que está fuertemente influenciada por su decisión política en favor del absolutismo. Esta posición política lo lleva a escoger textos ad-hoc que apoyan su teoría y a rechazar otros que no lo hacen, dejando así fuera importantes aspectos del cristianismo, uno de los cuales, el más central, es la naturaleza de Jesucristo como Dios-hombre y la interpretación contractualista del federalismo judío. El artículo hace uso de estudios de reconocidos investigadores (Elazar, Pangle, Kraynak, Ratzinger entre otros) y el autor concluye que Hobbes exhibe una visión reduccionista del cristianismo que influye en su teología política.
El concepto de apariencia en Kant y la crítica a la metafísica dogmática
Authors: Ramas San Miguel Clara
Published: February 2024

En este trabajo se investiga el concepto de apariencia [Schein] que Kant desarrolla en la Crítica de la razón pura y textos complementarios. Se sostendrá que la propuesta crítica de Kant ha de ser comprendida en relación con la tradición metafísica previa —«metafísica dogmática»— y que el concepto de apariencia constituye un punto de anclaje privilegiado para abordar esta relación, además de situar a Kant como pensador moderno. Asimismo, se ofrece, siguiendo a G. Lebrun, una propuesta de distinción entre apariencia lógica y trascendental. Finalmente se demarca el lugar de la ontología y la metafísica tras la operación crítica kantiana.
El ensueño del espíritu. Subjetividad e imaginación en la «Anthropologie» de Hegel
Authors: Prósperi Germán Osvaldo
Published: February 2024

En este artículo nos proponemos realizar una lectura de la sección «Anthropologie» de la Enzyklopädie hegeliana con el objetivo de mostrar la particular concepción de lo humano que, incluso a pesar de su autor, se desprende de ella. Para esto analizaremos algunos fenómenos (el niño en el vientre materno, el sonambulismo magnético, etc.) abordados por Hegel en dicha sección. Concluiremos que el «alma» (Seele), objeto específico de la «Anthropologie», cumple la misma función limítrofe (entre naturaleza y espíritu, sensibilidad y entendimiento, etc.) que ha cumplido la imaginación a lo largo de la historia de la metafísica.
La presencia del Absoluto y la realidad de la nada en Hegel y Tomás de Aquino. Una aproximación a la problemática desde la interpretación de Cornelio Fabro
Authors: Benavides Cristian
Published: February 2024

Tanto la obra de Hegel en la modernidad como la obra de Tomás de Aquino en el medioevo, representan dos de los mayores esfuerzos que se han realizado en el pensamiento filosófico por dar explicación a las grandes interrogantes y problemas de la metafísica. No cabe duda de que la presencia o inmanencia de lo Absoluto en lo finito, como así también la concepción de la nada, son temas de particular profundidad en la reflexión especulativa y ocupan un lugar de privilegio en la misma. En este escrito se analizarán de forma concisa ambas cuestiones, siguiendo la lectura e interpretación de los dos autores antes mencionados llevada a cabo por el filósofo italiano Cornelio Fabro.
Escatología y mesianismo en Heidegger: una interpretación desde san Pablo
Authors: Chillón José Manuel
Published: February 2024

El artículo trata de plasmar cómo la influencia de Pablo de Tarso en Heidegger puede explicar no sólo la concepción de la Zeitlichkeit como sentido del ser del ente que es el Dasein, sino el concepto de tiempo después de la Kehre. Si aquella concepción escatológica hizo del futuro el éxtasis principal de la existencia que se sabe tan abierta y proyectiva como caída y deyectada por la muerte adveniente, esta otra dimensión mesiánica insiste más en el tiempo que resta, en el presente que nos queda. De este modo, en las dos grandes etapas de Heidegger podrían encontrarse resonancias de las dos determinaciones del kairós que, en nuestra opinión, traslucen las epístolas paulinas.
El problema comprensión-interpretación en Gadamer: una aproximación desde el análisis de la palabra poética y la filosófica
Authors: Gazmuri Rosario
Published: February 2024

Para Gadamer, «el ser que puede ser comprendido es lenguaje», afirmación que implicaría que toda comprensión se da en la lingüisticidad. Por otra parte, afirma que si hay lingüisticidad, hay interpretación. Ahora bien, la cuestión que queda en entredicho en su obra es si esto implica que dicha lingüisticidad es concomitante con la comprensión, es decir, si en toda comprensión hay una mediación lingüística. El presente artículo busca indagar en el análisis de la palabra poética y la filosófica, para desde tal análisis ver las posibilidades de resolución de la relación entre comprensión e interpretación.
Pensando el amor: la propuesta de Harry G. Frankfurt
Authors: Aragón Aranda Gabriel
Published: February 2024

El presente trabajo se propone subrayar la relevancia filosófica del amor acudiendo al desarrollo analítico que del mismo realiza Harry G. Frankfurt. Para ello nos valdremos de la categorización que establece Bennett Helm y encuadraremos la teoría de Frankfurt dentro de una categoría concreta: la del amor como «gran preocupación» [«robust concern»]. Esto nos servirá para atender a la psicología moral de dicho autor y al peso decisivo que el amor juega en la misma; revestido aquel, como afirma Frankfurt, de una autoridad tal que dota de sentido último a nuestro razonamiento práctico. Finalmente, y expuesta la relevancia del amor dentro de todo este proceso, se procederá a discutir de la mano de Jonathan Lear si el amor posee la autoridad que Frankfurt le asigna.
La muerte como otredad: un análisis de la interioridad y el yo a través de Muerte y alteridad de Byung-Chul Han
Authors: Morán Roa Alberto
Published: February 2024

En Muerte y alteridad (2002), de reciente publicación en lengua española (2018), Byung-Chul Han analiza una trayectoria filosófica que atraviesa el pensamiento de Kant, Heidegger y Lévinas para señalar la que identifica como una postura caracterizada por la interioridad, desde la cual se entiende al yo como positividad unitaria frente a la negatividad de lo heterogéneo, la alteridad y la muerte. Estas premisas incurrirían en solipsismos, aporías y contradicciones que nos proponemos examinar, a fin de afinar y valorar críticamente la caracterización llevada a cabo por Han. Tanto el heroísmo del yo como del amor constituirían, concluye el filósofo de origen coreano, respuestas equivocadas al hecho de la muerte, proponiendo a este respecto una apertura a la exterioridad de rasgos budistas que implicaría un vaciamiento del yo. Esta alternativa, de ecos religiosos, invita a una reflexión sobre la naturaleza de su proyecto filosófico, no solo con respecto al afrontamiento de la muerte, sino como respuesta a las problemáticas de la modernidad.
Absolutos morales en la Teoría Neoclásica de la Ley Natural
Authors: Caviedes Thomas Gabriela Sofía
Published: February 2024

Este trabajo se propone mostrar cómo la Teoría Neoclásica de la Ley Natural fundamenta la existencia de normas morales absolutas, cuál es su relevancia para la filosofía moral, y qué críticas pueden ser formuladas a la argumentación de los autores. Ellos postulan que la ley natural, mediante normas, lleva a elegir y proteger bienes humanos básicos, correspondientes a los diversos aspectos de la naturaleza humana, evitando su destrucción, daño o impedimento. Aunque la mayoría de las normas morales admiten excepción, nunca lo hacen las que prohíben realizar un acto que siempre daña directamente un bien básico, pues tal acto no puede compatibilizarse con la propia autorrealización, y atenta contra la dignidad humana. La división del trabajo tomará la siguiente forma: en los primeros cuatro apartados se abordarán los conceptos clave para la defensa de una norma absoluta en la Teoría Neoclásica, en el quinto se enlazarán los conceptos al modo que los autores lo hacen para demostrar la existencia de absolutos morales y someter el consecuencialismo a crítica, y en el sexto se hará una breve revisión crítica de los argumentos presentados.
Igualdad, libertad, educación
Authors: Gil José María
Published: February 2024

Quizá uno de los problemas más importantes y complejos del siglo XXI, después del muy urgente problema de evitar una guerra atómica, es la tarea de encontrar los caminos para organizar una sociedad que concilie la libertad cultural e individual con el desarrollo de una organización eficiente del estado y la economía. Por medio de un currículum común, la educación puede empezar a ayudarnos a resolver este problema urgente. El desarrollo curricular se erige sobre relaciones tensas, por ejemplo la tensión entre la lengua estándar y las variedades regionales o sociales, o la tensión entre las demandas laborales y la vocación. Sin embargo, esas relaciones tensas no son inconciliables. Por el contrario, involucran una tensión virtuosa entre igualdad y libertad, los dos grandes valores que deben preservarse y fortalecerse para alcanzar la felicidad.
Formación ética y dilemas éticos
Authors: Iracheta Fernández Francisco Javier
Published: February 2024

En este artículo me propongo analizar el significado que tiene la idea de formar éticamente a profesionistas para resolver «dilemas éticos». Partiendo de la base de las propuestas más significativas de la UNESCO para legitimar la pertinencia de la formación ética en la educación profesional en el siglo XXI, me interesa mostrar el sentido que adquiere el concepto de dilema ético y lo que significa aceptar su legitimidad, para de aquí invitar a una reflexión sobre los fundamentos básicos formales de una pedagogía ética que todo docente que enseña ética a nivel profesional tendría que considerar para enseñar a los futuros profesionistas a enfrentar este singular problema de la razón práctica.
Neorrepublicanismo y virtudes cívicas. La necesidad de una ética ciudadana
Authors: Urrutia León Manuel M.ª
Published: February 2024

Uno de los acontecimientos teóricos más importantes, ocurridos en la filosofía política de las últimas décadas, es la reformulación del paradigma republicano. Este neorrepublicanismo pretende hacer frente a la profunda crisis de la democracia liberal (corrupción, insolidaridad, apatía ciudadana, etc.), en nuestra época de predominio neoliberal. En el presente artículo desarrollo principalmente su visión de la ética ciudadana; es decir, la importante idea de que la república necesita formular un cierto bien común y promover la virtud cívica de sus ciudadanos, si aspiramos a una sociedad libre de dominación, más justa y solidaria.
La difícil empresa de traducir «Del sentimiento trágico de la vida». En torno a unas cartas inéditas entre Miguel de Unamuno y sus traductores
Authors: Martín Gómez María
Published: February 2024

Mientras que Miguel de Unamuno vivió, su libro Del sentimiento trágico de la vida fue traducido a siete idiomas. Esta circunstancia provocó que los traductores se dirigieran a su autor para comentar la obra así como para hacerle partícipe de algunos problemas que les iban surgiendo. El epistolario conservado entre Miguel de Unamuno y sus traductores nos ofrece así una fuente inestimable de conocimiento para comprender mejor la génesis y el alcance de la que, según Unamuno, fue su obra capital. Gracias al hallazgo de unas cartas inéditas, podemos reconstruir cómo fue el proceso de traducir Del sentimiento trágico de la vida, teniendo en cuenta todos los acontecimientos que se sucedieron al inicio del siglo XX.
Economía axiomatica: sobre ética y afectos en el supuesto de codicia de la conducta racional
Authors: Calvo Patrici
Published: February 2024

El egoísmo constituye uno de los aspectos fundamentales de la teoría económica tradicional. Propuesto y desarrollado durante la revolución marginalista y convertido en axioma por la escuela neoclásica, la natural propensión del agente económico a maximizar su propio interés otorga robustez y consistencia a la teoría mediante la reducción de toda la realidad comportamental del agente económico. El objetivo del presente estudio es tratar de mostrar las implicaciones éticas y afectivas para una teoría axiomatizada con pretensiones de consistencia y completitud como la desarrollada y defendida por la teoría económica tradicional.
Psychologische Sicherheit und ihre Bedeutung für eine gesunde Fehlerkultur
Authors: Queckbörner Boris
Published: February 2024

Der Beitrag stellt in aller Kürze das Konzept der psychologischen Sicherheit vor, wie es v. a. von Amy C. Edmondson ausgearbeitet worden ist. Mit Edmondson wird argumentiert, dass psychologische Sicherheit eindeutig positive und nachhaltige Auswirkungen auf die Organisationskultur entfaltet. So werden Mitarbeiter*innen in einer psychologisch sicheren Organisation angehalten, sich aktiv in die Gestaltung der Arbeitsprozesse einzubringen, um dadurch v. a. die sog. „Epidemie des Schweigens“ zu bekämpfen. In der Praxis gelingt dies primär dadurch, dass eine Entstigmatisierung von Fehlern und Scheitern stattfindet. Anstatt eine Kultur der Schuldzuweisung zu fördern, nehmen psychologisch sichere Organisationen Fehler und Scheitern als Chancen für organisationale Lernerfahrungen wahr. In der Folge entsteht eine positive Fehlerkultur, die am Ende zur kontinuierlichen Weiterentwicklung der Organisation und ihrer Mitarbeiter*innen beiträgt.
Quantification of blood glial fibrillary acidic protein using a second-generation microfluidic assay. Validation and comparative analysis with two established assays
Authors: Fazeli Badrieh , Gómez de San José Nerea , Jesse Sarah , Senel Makbule , Oeckl Patrick , Erhart Deborah K. , Ludolph Albert C. , Otto Markus , Halbgebauer Steffen , Tumani Hayrettin
Published: February 2024

Objectives

Increased levels of glial fibrillary acidic protein (GFAP) in blood have been identified as a valuable biomarker for some neurological disorders, such as Alzheimer’s disease and multiple sclerosis. However, most blood GFAP quantifications so far were performed using the same bead-based assay, and to date a routine clinical application is lacking.

Methods

In this study, we validated a novel second-generation (2nd gen) Ella assay to quantify serum GFAP. Furthermore, we compared its performance with a bead-based single molecule array (Simoa) and a homemade GFAP assay in a clinical cohort of neurological diseases, including 210 patients.

Results

Validation experiments resulted in an intra-assay variation of 10 %, an inter-assay of 12 %, a limit of detection of 0.9 pg/mL, a lower limit of quantification of 2.8 pg/mL, and less than 20 % variation in serum samples exposed to up to five freeze-thaw cycles, 120 h at 4 °C and room temperature. Measurement of the clinical cohort using all assays revealed the same pattern of GFAP distribution in the different diagnostic groups. Moreover, we observed a strong correlation between the 2nd gen Ella and Simoa (r=0.91 (95 % CI: 0.88–0.93), p<0.0001) and the homemade immunoassay (r=0.77 (95 % CI: 0.70–0.82), p<0.0001).

Conclusions

Our results demonstrate a high reliability, precision and reproducibility of the 2nd gen Ella assay. Although a higher assay sensitivity for Simoa was observed, the new microfluidic assay might have the potential to be used for GFAP analysis in daily clinical workups due to its robustness and ease of use.
Dopamine functionalized coatings for corrosion protection of metallic implants and advanced drug delivery: a review
Authors: Talha Mohd
Published: February 2024

The surface treatment of metallic implants is significant for their in-vivo performance. Biocompatible coatings play a crucial role in corrosion protection and other practical uses of biomedical devices to evade surgery failure and enhance their functions. Polydopamine (PDA), a mussel-inspired synthetic polymer, exhibits high potential as an adhesive middle layer to enhance the bonding at the interface between the metal substrate and coating materials and used for corrosion protection of the implants. Owing to its excellent biocompatibility along with unique drug loading perspective, several PDA-modified nanoparticles have also been preferred as drug carriers. This featured article is dedicated to summarizing the significance of PDA as a coating material for clinical applications. It was begun by describing the polymerization process of dopamine and then describes the PDA as an effective coating material for corrosion protection of implants with proposed mechanism. The beneficial effects of PDA containing coatings on corrosion protection of implants were also discussed. Next, was focused on PDA-modified nanostructures and emphasized the biocompatibility of PDA. The latest developments of PDA modified coatings/nanoparticles in advanced drug delivery applications were also discussed.
On the asymptotics of eigenvalues for a Sturm-Liouville problem with symmetric single-well potential
Authors: Başkaya Elif
Published: February 2024

In this article, Sturm-Liouville problem with one boundary condition including an eigenparameter is considered, and the asymptotic expansion of its eigenparameter is calculated. The problem also has a symmetric single-well potential, which is an important function in quantum mechanics.
Permittito aperiat oculum: typological considerations on P-lability and its interaction with morphosyntactic alignment in Latin medical texts
Authors: Ongenae Tim A.F.
Published: February 2024

This paper explores the diachrony of Latin P-labile verbs (verbs that can be used transitively and intransitively with the preservation of the Patient and without a formal change), availing itself from evidence in medical and veterinary texts from the first to seventh century AD. The first part of the analysis discusses the influence of verbal semantics on the domain of lability in these texts and how lability developed as a diathetic strategy for the anticausative, the causative and the passive in Latin. Special attention is paid to the increase of P-lability as an anticausative strategy and its relation to the mediopassive and reflexive anticausative strategies in Late Latin. The second part of the analysis proposes a new explanation for the increase of P-lability in Latin and discusses the consequences of the development of a semantic-based alignment in Late Latin (the extended accusative) on the syntax and development of P-labile verbs.
High gain and high-efficiency compact resonator antennas based on spoof surface plasmon polaritons
Authors: Tian Dou , Kianinejad Amin , Wang Jiafu , Guo Chen , Zhang Anxue
Published: February 2024

We proposed a high gain high-efficiency compact metallic resonator antenna operating at even-mode meander line spoof surface plasmon polaritons (MLSSPPs). The high radiation efficiency is caused by the bulk of fields crowded in lossless air near the antenna rather than in lossy dielectric as in conventional dielectric resonator antennas (DRAs). The proposed antenna also exhibits compact size because of its high effective refractive index. A reliable equivalent circuit model is proposed for the design of the resonator antenna with basic mode of half wavelength resonant mode. As an example, a meander-line SSPP antenna is designed, fabricated and measured. Both the simulated and measured results show the advantages of high efficiency and compact volume. In addition, the antenna achieves higher gain and wider relative bandwidth per wavelength cube volume compared with its counterparts. This method provides a good alternative for designing DRAs.
Quantitative impact assessment of transmission congestion and demand side management on electricity producers’ market power
Authors: Mittal Anupam , Singh Kanwardeep
Published: February 2024

This paper presents the impact of transmission congestion and demand side management on Electricity Producers’ market power using the quantitative investigation of pool-based market clearing mechanism. The mathematical problem formulation for pool-based market clearing consists of maximization of social welfare objective function, which incorporates maximization of demand benefit obtained from flexible demand bids and minimization of Electricity Producers’ real and reactive power costs obtained from actual and strategic supply bids. In this problem formulation, the nonlinear modeling of power system is used for real and reactive power flow equality constraints, transmission line capability inequality constraints (for incorporating the impact of transmission congestion), and generator capability curve equality constraints. The impacts of demand side management have been incorporated in the problem by considering single-period and multi-period demand flexibilities, and distributed generation placement at appropriate locations. The formulated optimization problem has been solved using nonlinear programming, which provides the nodal prices as byproducts of the solution. The electricity producers’ capability to exercise market power has been analyzed from their revenue and surplus indices, which have been obtained from nodal prices. Various case studies have been simulated on IEEE 30-bus system for quantitative determination of electricity producers’ market power. The results obtained are very interesting and demonstrate demand side strategies to tackle the electricity producers’ market power with actual and strategic bidding under normal and congested system conditions.
Student and teacher beliefs about oral corrective feedback in junior secondary English classrooms
Authors: Ye Xuejun , Hu Guangwei
Published: February 2024

Beliefs about oral corrective feedback, especially those held by young EFL learners, are under-researched. This paper reports on a study designed to investigate whether Chinese junior secondary students and teachers share similar beliefs about oral corrective feedback (OCF) in English instruction and how students’ English proficiency may relate to their OCF beliefs. A questionnaire was completed by 87 teachers and 597 students, and semi-structured interviews were conducted with 15 students with varying English proficiency. Statistical analyses of the questionnaire data found significant differences between student and teacher beliefs with respect to general attitude toward OCF, uptake of OCF, preference for certain types of OCF, and provision of OCF based on the gravity of errors. Students at different proficiency levels were also found to hold different beliefs about the timing and uptake of OCF. A content analysis of the interviews revealed more detailed similarities and differences between the OCF views held by students with varying English proficiency. These findings suggest that student beliefs are shaped by various individual, situational, contextual and cultural factors. Pedagogical efforts that can be made to maximize the effects of OCF in the classroom are discussed in light of these findings.
Therapeutic potential of flavonoids in ovalbumin induced asthma in mice model
Authors: Singh Vedpal , Singh Rohit , Dhanabal Sangai P. , Katrolia Archita
Published: February 2024

Objectives

Desmodium triquetrum DC (Fabaceae) is a plant commonly used in Indian traditional medicine to treat allergies. Asthma is a severe condition, with an estimated 300 million deaths annually, which could increase to 400 million by 2025. Flavonoids, a class of compounds found in many plants, have been found to have beneficial effects in treating asthma. In this study, researchers focused on three flavonoids, Baicalein, Naringin, and Neohesperidin, derived from Desmodium triquetrum DC, to investigate their potential as a treatment for asthma.

Methods

The study used an aerosolized ovalbumin-induced asthma model to evaluate the effects of the flavonoids on various substances in bronchoalveolar lavage fluid, including total differential leukocyte, nitrite, nitrate, TNF, IL-4, and IL-13. The researchers also measured the levels of myeloperoxidase and malondialdehyde in the lungs.

Results

The results showed that ovalbumin-induced airway hyper-responsiveness led to a significant increase in pro-inflammatory cytokine levels. However, the flavonoids significantly decreased the severity of airway inflammation. Histopathology results also supported the effectiveness of the flavonoids. These findings suggest that these flavonoids could be a supplementary and alternative treatment for asthma by inhibiting the pro-inflammatory pathway.

Conclusions

The findings suggest that the isolated compounds have the potential to act cumulatively to decrease the levels of the tested cytokines, normalize eosinophil and activated lymphocyte counts, and significantly reduce MPO and MDA. This indicates a possible respiratory mechanism of action for the drugs.
Hereditary spastic paraplegia type 35 in a Turkish girl with fatty acid hydroxylase-associated neurodegeneration
Authors: Engin Erdal Ayşenur , Yürek Burak , Kıreker Köylü Oya , Ceylan Ahmet Cevdet , Çıtak Kurt Ayşegül Neşe , Kasapkara Çiğdem Seher
Published: February 2024

Objectives

The fatty acid 2-hydroxylase gene (FA2H) compound heterozygous or homozygous variants that cause spastic paraplegia type 35 (SPG35) (OMIM # 612319) are autosomal recessive HSPs. FA2H gene variants in humans have been shown to be associated with not only SPG35 but also leukodystrophy and neurodegeneration with brain iron accumulation.

Case presentation

A patient with a spastic gait since age seven was admitted to the paediatric metabolism department. She was born to consanguineous, healthy Turkish parents and had no family history of neurological disease. She had normal developmental milestones and was able to walk at 11 months. At age seven, she developed a progressive gait disorder with increased muscle tone in her lower limbs, bilateral ankle clonus and dysdiadochokinesis. She had frequent falls and deteriorating school performance. Despite physiotherapy, her spastic paraplegia was progressive. Whole exome sequencing (WES) identified a homozygous NM_024306.5:c.460C>T missense variant in the FA2H gene, of which her parents were heterozygous carriers. A brain MRI showed a slight reduction in the cerebellar volume with no iron deposits.

Conclusions

Pathogenic variants of the FA2H gene have been linked to neurodegeneration with iron accumulation in the brain, leukodystrophy and SPG35. When patients developed progressive gait deterioration since early childhood even if not exhibited hypointensity in the basal ganglia detected by neuroimaging, FA2H-related neurodegeneration with brain iron accumulation should be ruled out. FA2H/SPG35 disease is characterised by notable clinical and imaging variability, as well as phenotypic diversity.
Coagulation assessment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infected pregnant women and their offspring by using rotational thromboelastometry (ROTEM)
Authors: Mitsiakos Georgios , Gialamprinou Dimitra , Kontovazainitis Christos-Georgios , Moraitis Athanasios , Katsaras Georgios , Pouliakis Abraham , Diamanti Elissavet
Published: February 2024

Objectives

During pregnancy, severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection may intensify the gestational procoagulant state. Coronavirus disease 2019 (COVID-19) associated coagulopathy (CAC) constitutes an exacerbated immunothrombosis response. There is limited data regarding the coagulation profile of SARS-CoV2-infected pregnant women, especially those with CAC, and the effect on their offspring. This prospective study aimed to compare the hemostatic profile of those women and their neonates with healthy mother–neonate pairs.

Methods

Conventional coagulation tests (CCTs) and rotational thromboelastometry (ROTEM) were employed to evaluate the hemostatic profiles. Neonates were assessed at birth and on the fourth day of life.

Results

We enrolled 46 SARS-CoV2-infected pregnant women and 22 healthy controls who gave birth to 47 and 22 neonates, respectively. CAC was present in 10 participants. SARS-CoV2-infected pregnant women manifested slightly prolonged APTT and higher fibrinogen levels. Regarding ROTEM, we noted decreased FIBTEM CFT, with higher A10, A-angle, and MCF. The CAC group presented lower platelet count, increased fibrinogen levels, and higher FIBTEM A10 and MCF. PT was slightly prolonged at birth in neonates born to SARS-CoV2-infected mothers. During the fourth day of life, D-dimers were significantly increased. Concerning ROTEM, neonates born to SARS-CoV2-infected mothers showed lower FIBTEM CT at birth.

Conclusions

SARS-CoV2-infected pregnant women present a hypercoagulable profile. Hypercoagulability with elevated fibrinolysis and lower platelet count is observed in participants with CAC. The coagulation profile of neonates born to SARS-CoV2 mothers seems unaffected. Elevated D-dimers on the fourth day may reflect a neonatal inflammatory response to maternal SARS-CoV2.
Public Reason, Coercion, and Overlapping Consensus
Authors: Spector Ezequiel
Published: February 2024

The idea of public reason involves a standard of legitimacy that requires that laws and institutions be acceptable to all reasonable people, regardless of their conceptions of the good. Many philosophers have argued that public reason should be understood as an answer to the question of how to justify state coercion. However, some authors have criticized this traditional account because it overlooks noncoercive state actions that seem appropriate topics of public reason. More recently, some philosophers have defended the traditional account against that objection. In this paper, I argue that these approaches cannot effectively deal with that objection and offer a different version of the traditional account that can do so. This version rests on the ideas of overlapping consensus and stability. According to this version, the point of public reason is preserving an overlapping consensus on a coercive system of laws and institutions and achieving a stable society.
Quantifying robustness against sharp bending in an integrated topological interface of valley photonic crystals
Authors: Guo Chao-Heng , Tang Guo-Jing , Li Meng-Yu , Chen Wen-Jie , He Xin-Tao , Dong Jian-Wen
Published: February 2024

Sharp-bending waveguide is a key element for ultra-compact and densely integrated photonic devices, which is promising to enlarge the capability of modern information processing in a single chip. Topological photonics manifest the nature of robust propagation against sharp bending and such robustness has been experimentally demonstrated in topological integrated interfaces. It is important to quantify the bending loss of topological interface but has remained exclusive. In this work, we report on the characterization of sharp-bending robustness in the integrated topological interface of valley photonic crystals (VPCs) by experimentally quantifying the ultralow bending loss. The VPCs are designed on a standard silicon-on-insulator platform with the inversion-symmetry broken in honeycomb lattice, and four types of topological interfaces can be constructed by two topologically-distinct VPCs. As one of the representative cases, zigzag-AA interface is applied to demonstrate the robust propagation along sharp bending. In experiment, we fabricate a series of VPC interfaces with different turn number and the same transmission distance, which perform the ultralow bending loss less than 0.02 dB per 120-deg turning. Furthermore, we experimentally characterize the propagation loss in the integrated interfaces. Our approach not only shows the ability of VPC topological interfaces to suppress backscattering stemming from sharp bending, but also paves the way for topological nanophotonic dense integration.
Crystal structure of bis(3,5-diisopropyl-1H-pyrazol-4-ammonium) tetrafluoroterephthalate, 2[C9H18N3][C8F4O4]
Authors: Fujisawa Kiyoshi , Harakuni Seigo , Iwai Kako , Ageishi Keigo , Tiekink Edward R. T.
Published: February 2024

2[C9H18N3][C8F4O4], monoclinic, I2/a (no. 15), a = 10.2282(4) Å, b = 11.9366(5) Å, c = 24.5548(12) Å, β = 98.948(4)°, V = 2961.4(2) Å3, Z = 4, Rgt
(F) = 0.0456, wRref
(F
2) = 0.1217, T = 178 K.
The crystal structure of t-butyl 7-[4-(4-fluorophenyl)-2-[(methanesulfonyl)(methyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate, C26H36FN3O6S
Authors: Zou Jing , Sheng Lv-Qing , Xu Xin-Xin , Xu Rou-Han , Jiang Cheng-Jun
Published: February 2024

C26H36FN3O6S, monoclinic, P21 (no. 4), a = 10.6615(4) Å, b = 8.7470(3) Å, c = 29.4342(11) Å, α = 9°, β = 95.6130(10)°, γ = 90°, V = 2731.76(17) Å3, Z = 4,

R
gt

${R}_{\text{gt}}$

(F) = 0.0439,

w

R
ref

$\mathrm{w}{R}_{\text{ref}}$

(F
2) = 0.1083, T = 170 K.
MTT assay of human anti-breast cancer cells (MCF-7) in vitro potentials and phytochemicals screening of the root bark extracts from Cassia sieberiana
Authors: Magashi Labaran Abdulkadir
Published: February 2024

Medicinal plant Cassia sieberiana root bark was investigated for phytochemicals and Anti-Breast Cancer cells (MCF-7) properties, using Chemical Separations and MTT assay in vitro. The C. sieberiana root bark was extracted with soxhlet extractor using different solvents based on polarity guided method and the respective extracts were concentrated under reduced pressure. These extracts were screened for their phytochemicals qualitatively using standard methods. Percentage Yields and Physico-Chemical Evaluation of the Extracts from the various fractions were recorded. The results of phytochemicals screening revealed the presence of some secondary metabolites of pharmacological significance in the Methyl acetate, MeOH and 70 % MeOH root bark extracts including Saponins, Quinones, Phenolic, Steroids, Tannins, Flavounoids, Terpenoids, Anthraquinones, Cardiac-glycosides, Alkaloids, Carbohydrates, Glycosides and Coumarins. Results obtained from MTT assay revealed that Extracts of MeOH and 70 % MeOH samples shown a certain degree of inhibition towards MCF-7 cell line. IC50 were calculated using Graph Pad Prism 6 and results shown that IC50 of 245.3 μg/ml and 239.6 μg/ml dose dependent inhibitions in MCF-7 cells respectively, compared to Oxaliplatin IC50 of 38.04 μg/ml. Therefore, 70 % MeOH sample with IC50 of 239.6 μg/ml have shown more potential of inhibiting breast cancer cell, MCF-7 cells line. The inhibition of the root bark is attributed to some of the phytochemicals present in the plant.
Evaluating sustainability of Bhuj aquifer system, Western India using nuclear dating techniques
Authors: Roy Annadasankar , Sinha Uday Kumar , Hathi Bharatkumar , Chatterjee Sitangshu , Pant Diksha , Mohokar Hemant , Jaryal Ajay , Pant Harish Jagat , Saha Dipankar , Jain Ratan , Keesari Tirumalesh
Published: February 2024

Increasing population, food demands and climatic stressors pose an imminent threat to groundwater sustainability in regional aquifer systems globally. Limited availability of surface water and erratic/uncertain rainfall necessitates preservation of groundwater resources, which form reliable fresh water reserves in most of the arid regions. Bhuj Sandstone aquifer is one such fresh groundwater systems in Western India catering the domestic/irrigational needs for over 2 million population. Rapid groundwater depletion in this area warranted a mandatory conservation of groundwater resources for future sustainability. Nuclear techniques using 3H and 14C provide estimates of groundwater age that help in planning sustainable groundwater management. In this study, sustainability of deep groundwater was assessed using environmental radioactive isotopes (3H, 14C). Results indicate that 14C activity of the groundwater samples varies from 26 to 73.6 pMC (percent modern carbon). Considering the various biases and uncertainties present, multiple correction models were applied to obtain representative groundwater ages by incorporating stable (13C) isotope and hydrogeochemical data. The corrected and representative ages are found to range from 5.8 to 8.6 ka BP (thousand years before present). From the study it can be inferred that central Bhuj aquifer hosts paleo-groundwater while the western part is recently recharged. Therefore, over-exploitation of deep groundwater in central Bhuj aquifer may further lower the water levels and this would have long-term impact on the socio-economic development of Kutch region.
“Brain–breath” interactions: respiration-timing–dependent impact on functional brain networks and beyond
Authors: Nakamura Nozomu H. , Oku Yoshitaka , Fukunaga Masaki
Published: February 2024

Breathing is a natural daily action that one cannot do without, and it sensitively and intensely changes under various situations. What if this essential act of breathing can impact our overall well-being? Recent studies have demonstrated that breathing oscillations couple with higher brain functions, i.e., perception, motor actions, and cognition. Moreover, the timing of breathing, a phase transition from exhalation to inhalation, modulates specific cortical activity and accuracy in cognitive tasks. To determine possible respiratory roles in attentional and memory processes and functional neural networks, we discussed how breathing interacts with the brain that are measured by electrophysiology and functional neuroimaging: (i) respiration-dependent modulation of mental health and cognition; (ii) respiratory rhythm generation and respiratory pontomedullary networks in the brainstem; (iii) respiration-dependent effects on specific brainstem regions and functional neural networks (e.g., glutamatergic PreBötzinger complex neurons, GABAergic parafacial neurons, adrenergic C1 neurons, parabrachial nucleus, locus coeruleus, temporoparietal junction, default-mode network, ventral attention network, and cingulo-opercular salience network); and (iv) a potential application of breathing manipulation in mental health care. These outlines and considerations of “brain–breath” interactions lead to a better understanding of the interoceptive and cognitive mechanisms that underlie brain–body interactions in health conditions and in stress-related and neuropsychiatric disorders.
In vivo C6 glioma models: an update and a guide toward a more effective preclinical evaluation of potential anti-glioblastoma drugs
Authors: Pournajaf Safura , Afsordeh Nastaran , Pourgholami Mohammad Hossein
Published: February 2024

Glioblastoma multiform (GBM) is the most common primary brain tumor with a poor prognosis and few therapeutic choices. In vivo, tumor models are useful for enhancing knowledge of underlying GBM pathology and developing more effective therapies/agents at the preclinical level, as they recapitulate human brain tumors. The C6 glioma cell line has been one of the most widely used cell lines in neuro-oncology research as they produce tumors that share the most similarities with human GBM regarding genetic, invasion, and expansion profiles and characteristics. This review provides an overview of the distinctive features and the different animal models produced by the C6 cell line. We also highlight specific applications of various C6 in vivo models according to the purpose of the study and offer some technical notes for more convenient/repeatable modeling. This work also includes novel findings discovered in our laboratory, which would further enhance the feasibility of the model in preclinical GBM investigations.
Verum, focus and evidentiality in Conchucos Quechua
Authors: Bendezú-Araujo Raúl
Published: February 2024

For most Quechuan languages, the discourse enclitic=mihas been described as a (contrastive) focus marker and/or as a marker of direct evidentiality. In this paper, I argue that these claims do not seem to apply to Conchucos Quechua (Ancash, Peru). To challenge the association between=miand focus, I offer a quantitative analysis that strongly suggests that this connection is not categorical in nature. To contest the association between=miand direct evidentiality, I offer a qualitative analysis based on aquestion-under-discussion(QUD) model of discourse structure, using naturalistic data. I will argue that this enclitic is better characterised as an assertion operator, whose function is to bring closure to the current QUD (be it explicit or implicit). In this sense, the use of=miis reminiscent of what has been calledverumin the literature, and I thus explore how this characterisation fits within this discussion.