bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of regional poverty on public health expenditure efficacy across South Africa’s provinces: investigating the influence of historical economic factors on health
Authors: Dlamini Msawenkosi , Mbonigaba Josue
Published: November 2024

Introduction/objectives

More than half of South Africa’s population lives in poverty, with significant health disparities across different regions. This study investigates the effects of regional poverty and historical economic factors on the efficacy of public health expenditure to understand how socioeconomic contexts influence overall public health outcomes.

Methods

Our study utilized annual data from 2005 to 2019 for 9 provinces, drawing from the General Household Survey, Health Systems Trust database, and National Treasury’s Intergovernmental Fiscal Review. The primary health outcome was life expectancy at birth, while public health expenditure per capita was the main independent variable. We developed the Provincial Index of Multiple Deprivation to assess poverty, incorporating dimensions such as health, education, and living standards. We employed a two-way fixed effects model to examine the complex relationships between regional poverty, public health spending, and health outcomes.

Results

The study found that poverty levels moderate the impact of public health spending on health outcomes, as evidenced by varying results across different provincial regions. Health outcomes in poorer provinces were less influenced by public health spending than wealthier regions. Additionally, the study established that income per capita, along with its lagged values and the lagged values of public health expenditure per capita, did not significantly affect health outcomes as measured by life expectancy.

Conclusion/recommendations

The impact of health expenditure in South Africa is influenced by regional poverty levels. To maximize the effectiveness of health spending, equitable, region-specific interventions tailored to address the unique health challenges of each area should be implemented.
The effect of cultural capital on the physical fitness level of a Chinese older adult population: chain mediation of household income and stockpiling of physical fitness goods
Authors: Zhao Deqiang , Wang Yibei , Zhang Aoyu , He Jin , Gao Yibo , Chen Xiaoxiao , Jiang Lupei , Zhang Yanfeng
Published: November 2024

Background

Health behaviors of older people are influenced by many factors, and physical activity are important lifestyle behaviors that promote healthy aging.

Purpose

This study is to analyze the intrinsic mechanism of the influence of cultural capital on the physical fitness level of older people, and to provide a theoretical basis for the improvement of the differences in physical fitness level caused by the differences in physical fitness concepts of the classes brought about by cultural capital, and the unequal distribution of resources.

Methods

The subjects of this study were derived from people over 60 years old in the 2020 China National Fitness Activity Status Survey, and a total of 20,896 samples were obtained using the principle of multi-stage stratified random sampling. The dependent variable was assessed by the Physical Activity Rating Scale (PARS-3) to calculate the physical activity level score of the older adult population. Pearson correlation analysis and stratified regression methods were used to analyze and explore the factors influencing the physical fitness level of sport older adult people, followed by quantile regression to explore the distribution of the influence of institutional cultural capital in different physical fitness levels. The use of quantile regression not only provided a robust test of the results of stratified linear regression, but also analyzed the differential effects of institutional cultural capital among individuals with different fitness levels. Finally, Bootstrap methods were used to test the mediating effects of household income and physical cultural capital.

Results

Institutional cultural capital (p < 0.01), household income (p < 0.01), physical cultural capital (p < 0.01), and health status (p < 0.01) are all conducive to improving fitness levels among older people. Family income (95%CI = [0.467, 0.235]) and material cultural capital (95%CI = [0.199, 0.291]) play a chain mediating role.

Conclusion

Cultural capital has a positive impact on the health of older people, mediated by household income and stocks of sporting goods. An increase in the level of cultural capital of older persons is beneficial to the improvement of health perception. Therefore, it is possible to promote the improvement of physical fitness among older people through the enhancement of their cultural capital and to realize healthy aging.
Social work practice and outcomes in rehabilitation: a scoping review
Authors: Freymüller Nadja , Knoop Tobias , Meyer-Feil Thorsten
Published: November 2024

Social work is a long-established profession in health care and rehabilitation. Reviewing the evidence on effects of social work interventions shows inconsistencies, with several studies indicating positive, negative, or no significant effect at all. Against this background, the purpose of this paper is to provide an international overview of the research on social work practice in rehabilitation. Two research questions about the activities performed by social workers in rehabilitation settings and the reported outcomes to evaluate social work interventions were guiding the analysis. A scoping review was conducted in order to identify these activities and reported outcomes. The literature search was carried out in two databases (PubMed, SocINDEX). Additionally, the authors searched manually for literature in rehabilitation science and social work journals. Inclusion criteria encompassed the involvement of social workers and a description of their activities. The context in which social work's practice had to take place was a rehabilitation setting. A total of 2,681 records could be identified by searching the databases, journals, proceedings and reference lists. 66 sources met the predefined inclusion criteria. A majority of the identified activities that social workers perform are case related. Topics that may occur in these case encounters are the social environment of the patient, financial/social security, work-related issues and others. Of particular note are activities such as assessment, counseling and education. When applying the ICF framework, the outcomes are distributed across almost all components with an emphasis on Participation. This review demonstrates that social work has a vital role in the interprofessional rehabilitation team on an international level. However, there is still a need for more research about the effectiveness of social work interventions. We identified internationally common social work core activities/issues and derived a proposal for specific outcomes for future evaluation research.
The security implications of using feminist methodologies to study gender-based violence in Yemen
Authors: Al-Refaei Sawsan
Published: November 2024

Introduction

This paper examines the political and security implications of gender-based violence (GBV) research in Yemen during the period (2019–2023). As various radical groups are gaining power over Yemeni land, radical views toward women and gender equity and equality shape the experiences of GBV survivors, practitioners, and researchers in the North of Yemen. Policing Houthi ideologies in Yemen have curtailed GBV research and subjected feminist research to myriad risks. If this situation continues, experiences of women and girls in Yemen will not be captured by research. Their stories and needs will not be captured by humanitarian and peace-building actors.

Methodology

Findings of this study are based on primary data from key informant interviews with 25 GBV researchers actively engaged in Yemen. Sampling followed the snowballing technique.

Results

The findings examine political and security power dynamics after the Houthi radical group took control in the north of Yemen, and implications on GBV research design. Anti-feminist ideologies coupled with extreme security measures have impacted quality of GBV study methodologies as well as researchers' safety and mobility. Donors of previously established GBV programs and research were harassed to change research topics or lose permission to speak to local communities or collect data from aid beneficiaries. Researchers who do not follow new rules of engagement with the community are detained, harassed and their devices and databases are confiscated. Terms like “gender” and “GBV” are not deemed acceptable as these are western concepts that do not align with new community values. The findings highlight the need to use conflict-sensitivity and Do No Harm principles in settings where GBV work is scrutinized. It also challenges the orthodox definition of “GBV evidence” and explores the ethical implications of the use of alternative means to collecting data. Findings also provide insight into valuable alternative methodologies that allow local and national researchers to continue studying GBV in conflict impacted areas without exposing themselves to actual or perceived risk. The paper proposes concrete approaches that can mitigate political and security risk on both researchers and GBV survivors.
Efficacy of submucosal administration of tramadol on acute pain following third molar surgery: a systematic review and meta-analysis
Authors: Assari Ahmad Salem , Algharbi Elaf Mubarak Abdullah , Abuhabsha Abdulmajeed Mohammed , Alshammry Basel Basheer , Alanazi Yosef Aeed , Abuhaimed Reem Abdulaziz , Alzahrani Ali Mohammad Ali , Alduhaim Abdulrahaman Saud
Published: November 2024

Objectives

This systematic review aimed to assess the effectiveness of submucosal tramadol injections in post-operative pain management following third molar surgical extraction.

Materials and methods

Databases, such as PubMed, Scopus, ScienceDirect, and Cochrane Library, were systematically searched using relevant keywords. Randomized clinical trials that met the inclusion criteria were assessed to determine the effectiveness of tramadol in managing acute post-operative pain following third molar surgery.

Results

In total, seven studies with participants of 18 and over following randomized placebo-controlled trials were considered for the analysis. A submucosal injection of 2 ml (50–100 mg) of tramadol adjacent to the impacted mandibular third molar effectively controlled pain for up to 6–24 h following surgery. Non-serious adverse events, such as nausea, vomiting, and headache, were reported in two studies. Meta-analysis (subgroup analysis) revealed heterogeneity among the studies, demonstrating variability in the results across the included studies. In addition, tramadol demonstrated a significant decrease in post-operative pain.

Conclusion

Submucosal tramadol is an efficient, safe, and dependable method for reducing post-operative acute pain, particularly in the first 6 h following impacted third molar surgery. However, due to the observed heterogeneity in the research, there is need for cautious interpretation of the findings and potential limitations in the evidence base. To enhance the quality of evidence on this topic, we strongly recommend conducting new RCTs using established methodologies.

Clinical relevance

Post operative pain following third molar surgeries is one of the common complications. Submucosal tramadol injections were found to be successful in reducing post extraction pain as well as other morbidities.
Soils: the final frontier recedes
Authors: Garbisu Carlos , Alkorta Itziar , Unamunzaga Olatz
Published: November 2024

Approximately 20 years ago (June 11th, 2004), a highly reputable scientific journal, on a front cover much celebrated by soil scientists, printed an eye-catching phrase: “Soils: The Final Frontier”. In the introduction to that special issue, it was mentioned that “in many ways the ground beneath our feet is as alien as a distant planet”, to then state that, owing to the booming interest in soil research at that time, together with the development of advanced techniques (e.g., next-generation sequencing), subterraneana would be made “seem far less of an alien experience”. In this perspective article, using as illustrations, by way of example only, two topics of great interest nowadays – soil carbon sequestration and soil biodiversity –, it is claimed that, despite all the efforts devoted in the last 20 years to the understanding of the soil ecosystem, the “final frontier” appears to have receded, as we are discovering increasing levels of complexity that are slowing down our trip to the far reaches of the edaphic universe. Due to, among other features, its high structural and functional complexity, biodiversity, heterogeneity, opacity, and processual and dynamic nature, the soil still remains a great unknown (“a black box”). The ultimate goal of this perspective article is to draw attention to the need for further long-term investment in research into this highly complex and fascinating ecosystem.
Characterising diversity of rural farm households in Eastern Africa: implications for food security and intra-household decision-making
Authors: Henderson Adelaide , Barnes Andrew P. , Hammond James
Published: November 2024

The heterogeneity in East African small-holder agricultural systems influences the farm households’ welfare outcomes. We examine the heterogeneity of rural farm households in Eastern Africa and the influence of such diversity on household food security and how these relate to intra-household decision-making dynamics. Using data from the Rural Household Multi-Indicator Survey (RHoMIS) 1,199 households in Ethiopia, Kenya, Malawi and Uganda were typologized using partition-based cluster analysis. These were grouped into relatively homogenous classes reflecting their socio-demographic characteristics, resource endowment and farm orientation based at a country level to reflect the unique institutional conditions within these countries. Additional analysis was then used to characterise the differences in food insecurity and intra-household decision-making of these clusters. Five distinct farm household clusters were identified in Ethiopia and Kenya, four in Malawi and three in Uganda. The main factors differentiating the farm clusters were educational attainment of the household head, levels of resource endowment, market orientation and off-farm income. Market orientated clusters and clusters comprising more educated household heads were generally more food secure across all countries. In Ethiopia, Kenya and Uganda, women had greater decision-making control in clusters comprising least educated household heads. Female decision-making control was negatively associated with the resource endowment of clusters in Kenya, Malawi and Uganda. This emphasises the importance of understanding rural farm household heterogeneity when tailoring interventions to target household food insecurity and gender inequity in decision-making in Eastern Africa.
Fibular grafts in global reconstructive surgery: a bibliometric analysis
Authors: Zhang Zhi , Li Yuezhan , Cheng Lin , Deng Ying , Cai Yan
Published: November 2024

Background

Over the past few decades, fibular grafts have been widely utilized across 86 countries and regions globally for surgical reconstruction of various anatomical sites, including the mandible, upper extremities, lower extremities, spine, and in phalloplasty procedures. The present study aims to systematically investigate the developmental trajectory of fibular graft and identify research priorities for surgeons.

Methods

A bibliometric analysis was conducted by searching the Web of Science Core Collection on April 12, 2024, for articles published between 2004 and 2023 on fibular grafting, using the query TS = (“graft” OR “transfer” OR “flap”) AND TS = (“fibular”). We included full-text English articles and reviews, and exclude documents that were not related to fibular grafting or were non-research-oriented publications. GraphPad Prism, CiteSpace, and VOSviewer analyzed publication trends and co-citation networks, providing insights into fibular grafting research.

Results

A total of 2,884 fibular graft publications were analyzed. Out of 86 countries/regions, the United States and China stood out as the main contributors in terms of publication volume, while England had the highest citation rate per publication. The journals with the most publications and citations were The Journal of Craniofacial Surgery and Plastic and Reconstructive Surgery, respectively. Mark K. Wax had the most publications, while Hidalgo DA had the highest co-citation count. The most frequently occurring keywords were “reconstruction” and “mandibular reconstruction.” Co-citation reference clustering revealed a growing preference for vascularized fibular grafts over non-vascularized alternatives. The top 10 co-cited references were exclusively focused on mandibular reconstruction. Keyword bursts analysis showed that over the initial 20-year period, identified keywords fall into three main themes: graft design (e.g., osteoseptocutaneous flap, perforator flap), reconstruction areas (e.g., maxilla, extremity, ankle, spine and phalloplasty), and defect causes (e.g., pseudarthrosis, sarcoma, bone tumor). In particular, fibular grafts in phalloplasty represent an emerging trend among various anatomical reconstruction sites. In the last 5 years, there has been a notable rise in interest in 3D planning, virtual surgical planning, augmented reality, and reconstruction accuracy.

Conclusion

The findings offer an in-depth overview of the landscape of fibular graft research, highlighting key contributors and emerging trends.
The Role of Red Clover and Manure Fertilization in the Formation of Crop Yield of Selected Cereals
Authors: Suwara Irena , Pawlak-Zaręba Katarzyna , Gozdowski Dariusz , Leszczyńska Renata
Published: November 2024

The use of legumes in rotation is beneficial and is of great importance in sustainable agricultural production in line with the assumptions of the European Green Deal. The aim of the presented research was to evaluate the cultivation of red clover as an undersown crop for spring barley and as a forecrop for winter wheat on the yield and quality of spring barley and winter wheat. To achieve this goal, two long-term static experiments set up in 1955 were used, in which diversified mineral and organic fertilization were used in two rotations: rotation without red clover (sugar beet–spring barley–winter rapeseed–winter wheat) and rotation with red clover (sugar beet–spring barley with undersown red clover–red clover–winter wheat). The obtained results indicate that the Norfolk rotation with red clover, as well as varied fertilization and years of research, influence the yield of plants. The highest grain yields of spring barley (5.7 t ha−1) were ensured by mineral fertilization (NPK) and mineral fertilization in combination with manure (½NPK + ½FM). However, the highest yields of winter wheat grain (6.4 t ha−1) were recorded in the treatments with exclusive mineral fertilization (NPK), significantly lower yields in the treatments where mineral fertilizers were used in combination with manure (5.7 t ha−1) (½NPK + ½FM) and only manure (5.1 t ha−1) (FM). The lowest yields of both cereals were found on soil that had not been fertilized since 1955 (0). The grain yield of spring barley was not significantly differentiated by the sowing method and was similar for spring barley grown with and without undersown red clover. Including legumes in the rotation had a positive effect on the yield of winter wheat. Fertilization had the greatest impact on the protein content in cereal grains. The use of mineral fertilization (NPK) and mineral fertilization in combination with manure (½NPK + ½FM) ensured the highest protein content in the grain of spring barley and winter wheat. Mineral fertilization (NPK) increased the protein content in spring barley grain by 2.9 percentage points compared to the unfertilized treatment (0) and by 2.1 percentage points compared to exclusive manure fertilization (FM), and in winter wheat grain by 2.3 and 1.4 percentage points, respectively. The cultivation of red clover in the rotation also had a positive effect on the protein content in spring barley and winter wheat grains.
Integrated Transcriptome and Metabolomics Analysis Reveals That Probiotics and Tea Polyphenols Synergetically Regulate Lipid Metabolism in Laying Hens
Authors: Qin Ming , Ma Cai , Wang Zengguang , Liang Mingzhi , Sha Yufen , Liu Jiewei , Ge Shunjin , Guo Longzong , Li Ruili
Published: November 2024

Tea polyphenols (TP) and probiotics (PB) have been recognized for their ability to improve lipid metabolism and regulate immune function. However, their specific impact on lipid metabolism in laying hens has not been thoroughly elucidated. Therefore, this study sought to examine the effect of TP and Bacillus subtilis on lipid metabolism in laying hens through transcriptome and metabolome analyses. Two hundred Hy-line Brown layers were randomly allocated into four groups with supplemental dietary TP and PB alone and their combination for 8 weeks. Each treatment had 10 replicates of five birds. Supplementation with a TP and PB combination (TP-PB) increased redness (a*) (p < 0.05) compared to the control basal diet (CT). Dietary TP-PB decreased egg yolk and serum total cholesterol (TC) concentrations (p < 0.05) without affecting the content of total bile acid (TBA). The combined use of TP and PB significantly improved hepatic fatty acid synthetase (FAS) activity (p < 0.05) and reduced liver fat particles. Dietary TP-PB primarily influenced the transcript levels of genes involved in fat metabolic pathways. In particular, TP-PB supplementation reduced lipid storage by activating the Notch signaling pathway. Furthermore, the addition of TP-PB in the diet modulated the abundance of metabolic biomarkers associated with bile secretion and valine, leucine, and isoleucine degradation. An interaction network of mRNAs and metabolites was constructed associated with lipid metabolism, such as deoxycholic acid, TAG (14:3–14:3–20:5), PDK4, and HES4. Overall, these findings emphasized the potential health advantages of the TP and PB combination as a possible functional feed supplement in livestock nutrition.
Scenario-Based Modeling of Agricultural Nitrous Oxide Emissions in China
Authors: Bu Miaoling , Xi Weiming , Wang Yu , Wang Guofeng
Published: November 2024

Agricultural land in China represents a major source of nitrous oxide (N2O) emissions, and as population growth and technological advancements drive agricultural intensification, these emissions are projected to increase. A thorough understanding of historical trends and future dynamics of these emissions is critical for formulating effective mitigation strategies and advancing progress toward the Sustainable Development Goals. This study quantifies N2O emissions across 31 provinces in China from 2000 to 2021, employing the IPCC coefficient method alongside China’s provincial greenhouse gas inventory guidelines. The spatiotemporal evolution of emission intensities was examined, with the Stochastic Impacts by Regression on Population, Affluence, and Technology (STIRPAT) model employed to assess the influence of population, technological development, economic growth, and energy structure. The findings confirm that agricultural land remains the primary source of N2O emissions, with significantly higher levels observed in eastern coastal regions compared to western inland areas. Implementing targeted mitigation strategies, such as enhanced agricultural- and manure-management practices and region-specific interventions, is imperative to effectively curb the rising emission trends.
Estimation of Total Digestible Nutrient Concentration for Short-Panicle Cultivars of Forage Rice (Oryza sativa L.) Silage
Authors: Fukagawa Satoru , Ninomiya Kyohei , Ishii Yasuyuki
Published: November 2024

A linear regression model for predicting total digestible nutrient (TDN) concentration in forage rice (Oryza sativa L.) silage was previously developed with traditional cultivars (>30% dry matter, DM as panicle), and we here extend the linear regression model to two short-panicle cultivars, ‘Tachisuzuka’ and ‘Tachiayaka’ (<20% DM as panicle). Silage fermentation quality was superior for the short-panicle cultivars compared to the traditional ones, partly due to higher mono- and oligosaccharide concentrations in leaves and stems. Silage TDN concentration was previously estimated for traditional cultivars by in vitro dry matter digestibility (IVDMD) and crude ash (CA) concentration (estimated TDN = 0.329 × IVDMD − 0.688 × CA + 44.5, r2 = 0.815, p < 0.001). In vivo TDN concentration in silages of short-panicle cultivars, ranging from 49.5 to 58.3%, was nearly identical to the TDN concentration estimated by the equation with an error rate <5%, demonstrating that the new equation model can be satisfactorily applied to silages of short-panicle rice cultivars.
Risk Assessment and Recommended Approaches to Optimize Infection Control and Antibiotic Stewardship to Reduce External Ventricular Drain Infection: A Single-Center Study
Authors: Kelemen Jozsef , Sztermen Marton , Dakos Eva , Agocs Gergely , Budai Jozsef , Katona Jozsef , Szekeressy Zsuzsanna , Sipos Laszlo , Papp Zoltan , Bata Mate , Karczub Janos , Korompai Mate , Dunai Zsuzsanna A. , Kocsis Bela , Szabo Dora , Eross Lorand
Published: November 2024

Background: An external ventricular drain (EVD) is used to release elevated intracranial pressure by draining cerebrospinal fluid (CSF) from the brain’s ventricles. The establishment of an EVD is one of the most commonly performed neurosurgical procedures to treat intracranial pressure in patients. Nevertheless, infections are very frequent complications. Identifying the risk factors for EVD-related infections is a key to improving patient safety and outcomes. Methods: We conducted a retrospective, single-center study of patients who underwent EVD implantation between January 2022 and March 2024. Patients were classified into infected and non-infected groups based on their clinical symptoms, as well as laboratory and microbiological results. Patient characteristics and possible risk factors for infection were compared between the two groups. Results: In total, 123 patients treated with 156 EVDs were included in this study, with a mean age of 55.8 (range: 25–84) years. EVD-associated infections were observed in 37 patients (30%). We found no significant association between infection risk and patient characteristics, including gender, primary diagnosis, craniotomy, or immunosuppression. There was no significant difference in terms of EVD insertion, i.e., whether the insertion took place in the operating room (OR) with antibiotic prophylaxis or outside the OR with no periprocedural antibiotic treatment. However, within the intensive care unit (ICU), EVD infection was much lower (13%) if EVD insertion took place in a single-bed room compared to multiple-bed room insertions (34%). Furthermore, there were significant differences in terms of the duration of first EVD (both single and multiple catheterizations) (p < 0.0001) and the total catheterization time (p = 0.0001). Additionally, there was a significant association with patient days in the ICU and EVD catheterization. Conclusions: Revisiting infection control measures is necessary, with special attention to the replacement of EVDs in single-bed ICU rooms, to introduce antibiotic prophylaxis in the ICU. Minimizing unnecessary EVD manipulation during catheterization is crucial in order to decrease the risk of EVD infection.
Cinnamaldehyde in Focus: Antimicrobial Properties, Biosynthetic Pathway, and Industrial Applications
Authors: Jaramillo Jimenez Brandon Armando , Awwad Fatima , Desgagné-Penix Isabel
Published: November 2024

Trans-cinnamaldehyde (TCA), a major bioactive compound derived from cinnamon (Cinnamomum spp.), has garnered significant attention for its diverse therapeutic properties. Its broad-spectrum antimicrobial activity, targeting both Gram-positive and Gram-negative bacteria as well as various fungi, positions TCA as a potent natural antimicrobial agent. Beyond its antimicrobial effects, TCA demonstrates promising antidiabetic and anti-inflammatory activities, making it a valuable compound in medicinal and cosmetic applications. Recent studies have highlighted its role in disrupting microbial membranes, inhibiting biofilm formation, and modulating key metabolic pathways in pathogens. Furthermore, TCA has gained popularity in cosmetics due to its antimicrobial activity, antioxidant properties, and skin-friendly profile. This review provides a comprehensive overview of TCA’s antimicrobial potential, focusing on its mechanisms of action and its market and industrial applications. We also discuss the biosynthetic pathway of TCA, exploring both its natural production in cinnamon and advances in biotechnological production methods. As the demand for sustainable and natural antimicrobial agents grows, TCA emerges as a promising candidate for diverse applications. Finally, this review explores future directions for optimizing TCA production through metabolic engineering and synthetic biology approaches to meet industrial-scale demands.
Oxidative Stress and Inflammation in Cancer
Authors: Sorriento Daniela
Published: November 2024

Reactive oxygen species (ROS) are important signaling molecules, physiologically synthesized by oxygen metabolism [...]
Glutathione Peroxidases: An Emerging and Promising Therapeutic Target for Pancreatic Cancer Treatment
Authors: Iglesias-Matesanz Paula , Lacalle-Gonzalez Carlos , Lopez-Blazquez Carlos , Ochieng’ Otieno Michael , Garcia-Foncillas Jesus , Martinez-Useros Javier
Published: November 2024

Glutathione peroxidases (GPxs) are a family of enzymes that play a critical role in cellular redox homeostasis through the reduction of lipid hydroperoxides to alcohols, using glutathione as a substrate. Among them, GPx4 is particularly of interest in the regulation of ferroptosis, a form of iron-dependent programmed cell death driven by the accumulation of lipid peroxides in the endoplasmic reticulum, mitochondria, and plasma membrane. Ferroptosis has emerged as a crucial pathway in the context of cancer, particularly pancreatic cancer, which is notoriously resistant to conventional therapies. GPx4 acts as a key inhibitor of ferroptosis by detoxifying lipid peroxides, thereby preventing cell death. However, this protective mechanism also enables cancer cells to survive under oxidative stress, which makes GPx4 a potential druggable target in cancer therapy. The inhibition of GPx4 can trigger ferroptosis selectively in cancer cells, especially in those that rely heavily on this pathway for survival, such as pancreatic cancer cells. Consequently, targeting GPx4 and other GPX family members offers a promising therapeutic strategy to sensitize pancreatic cancer cells to ferroptosis, potentially overcoming resistance to current treatments and improving patient outcomes. Current research is focusing on the development of small-molecule inhibitors of GPx4 as potential candidates for pancreatic cancer treatment.
Forward Fall Detection Using Inertial Data and Machine Learning
Authors: Tufisi Cristian , Praisach Zeno-Iosif , Gillich Gilbert-Rainer , Bichescu Andrade Ionuț , Heler Teodora-Liliana
Published: November 2024

Fall risk assessment is becoming an important concern, with the realization that falls, and more importantly fainting occurrences, in most cases require immediate medical attention and can pose huge health risks, as well as financial and social burdens. The development of an accurate inertial sensor-based fall risk assessment tool combined with machine learning algorithms could significantly advance healthcare. This research aims to investigate the development of a machine learning approach for falling and fainting detection, using wearable sensors with an emphasis on forward falls. In the current paper we address the problem of the lack of inertial time-series data to differentiate the forward fall event from normal activities, which are difficult to obtain from real subjects. To solve this problem, we proposed a forward dynamics method to generate necessary training data using the OpenSim software, version 4.5. To develop a model as close to the real world as possible, anthropometric data taken from the literature was used. The raw X and Y axes acceleration data was generated using OpenSim software, and ML fall prediction methods were trained. The machine learning (ML) accuracy was validated by testing with data acquired from six unique volunteers, considering the forward fall type.
Research on User Demands and Functional Design of an AR-Based Interior Design and Display Platform for Recreational Vehicles
Authors: Zhang Xun , Wang Xiyu , Xu Wei
Published: November 2024

Background: Augmented Reality (AR) technology provides a new way for product design and display due to its unique interaction, enabling customers to experience products more comprehensively and immersively. Objective: To study the interactive form and application of AR technology in the interior design and display of RV, to provide new ideas and solutions for the interior design of RV, to optimize the user experience of customers and improve the work efficiency in the process of customized interior design of RV. Methods: Qualitative and quantitative research methods were adopted, the target customer groups were investigated based on the KANO model, the data were analysed, and the design suggestions for the function and interactive interface of the RV interior design display platform were summarized. Results: Based on the investigation and research, the specific functions of the RV indoor experience design platform and the needs of the target user groups were identified, including 12 essential needs, 5 charm needs, 1 expectation needs and 2 undifferentiated needs, which correspond to different functions, respectively. Finally, the main features of the platform are outlined, and the functional framework of the RV interior design and display platform is drawn. Conclusions: The interactive form of AR RV interior design includes user interface design and interactive mode design, which can greatly enhance user experience, optimize space utilization and enhance customized services. The application of AR technology in RV design has a high potential, providing theoretical and practical support for the design and development of the RV AR RV design display platform.
Preliminary XRF Analysis of Coal Ash from Jurassic and Carboniferous Coals at Five Kazakh Mines: Industrial and Environmental Comparisons
Authors: Junussov Medet , Mustapayeva Sezim
Published: November 2024

This study analyzes 105 coal ash samples from Jurassic and Carboniferous coals from five mines in Kazakhstan, Lenin, Saradyr, Bogatyr, Maikuben, and Shubarkol, focusing on the inorganic elemental compositions, their occurrence, and industrial and environmental implications. Methods include coal ash yield and volatile matter analysis, mineralogical characterization via low-temperature ash X-ray diffraction (LTA-XRD), and scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDS). High-temperature ash (HTA) was analyzed using energy-dispersive X-ray fluorescence (EDXRF), highlighting XRF’s potential for rapid multi-elemental analysis. Nine major elements (Al, Si, P, S, Fe, K, Ca, and Ti) and eleven trace elements (As, Cu, Cr, Zn, Pb, V, Ga, Mn, Ni, Y, Yb, and Zr) were identified in HTA samples through EDXRF. SEM and dendrogram analysis confirm their co-occurrence with quartz, kaolinite, pyrite, and accessory minerals such as chalcopyrite, zircon, rutile, and REE-bearing apatite. The elemental content of samples enhances industrial suitability by reducing emissions. Only Yb shows slight enrichment for economic benefits, along with La, Ce, and Nd, while concentrations of potentially toxic elements indicate minimal environmental risk. EDXRF demonstrates its efficiency for large-scale investigations, with all samples analyzed in a few days using automated overnight measurements. This approach shows promise for future studies focusing on trace elements, including REE.
Shallow Magmatic System of Arxan Volcano Revealed by Ambient Noise Tomography with Dense Array
Authors: Qu Lijuan , Tian You , Liu Cai , Li Hongli
Published: November 2024

The Arxan Volcanic Field (AVF) is an active volcanic region in Northeast Asia, and its last eruption occurred approximately 2000 years ago. Its eruption mechanism remains unknown. To investigate the shallow magma system beneath the volcanic cones in the AVF, we deployed a dense seismic array consisting of 227 portable seismographs and conducted high-resolution ambient noise tomography (ANT). The results of checkerboard test (CRT) and restoring resolution test (RRT) demonstrate that our imaging results are reliable. These results reveale significant slow-velocity anomalies at depths of 5~9 km below the Tianchi caldera and GD1213 volcano in Arxan, with the highest anomaly reaching up to approximately 15%. These anomalies suggest partial melting in a shallow magma chamber, indicating ongoing volcanic activity in the AVF. The velocity of the magma chamber corresponding to a melt fraction of approximately 7.4~12.9%. Therefore, the presence of the magma chamber poses potential hazards to the Arxan region, including volcanic eruptions and their associated risks.
Exploring the Biological Potential of Mountain Germander Polyphenolic Extract on Cellular Model Macromolecules, Human Cell Lines, and Microbiome Representatives
Authors: Mandura Jarić Ana , Durgo Ksenija , Huđek Turković Ana , Petek Petra , Petrinić Andrea , Šeremet Danijela , Vojvodić Cebin Aleksandra , Komes Draženka
Published: November 2024

In the context of revitalizing the use of traditional plant species as remarkable sources of bioactive compounds, the determination of their biological effects is of utmost importance. Among Lamiaceae species, Teucrium montanum (Mountain Germander) represents understudied Mediterranean plant species; it is rich in polyphenols, which are well-studied biologically active compounds for human disease prevention and the reduction of oxidative stress, i.e., phenolic acids, phenylethanoid glycosides, and flavonoids. For that purpose, the aim of this study was to investigate the antioxidant, cytotoxic, and genotoxic effects of Mountain Germander (MG) polyphenolic extract (0.025, 0.050, 0.150, and 0.500 mg extract mL−1) on the hepatocellular (HepG2), tongue (CAL 27), gastric (AGS), and colorectal (Caco-2) continuous human cancer cell lines, as well as its bacteriostatic potential on representative members of human microbiota. In addition, the antioxidant potential of the MG polyphenolic extract was determined using bovine serum album and DNA plasmid as cellular model macromolecules. In vitro analysis revealed a significant cytotoxic effect of all MG extract concentrations on AGS and Caco-2 cell lines after prolonged treatment (24 h). In addition, treatment with 0.500 mg extract mL−1 showed the most pronounced antioxidant effect under prolonged treatment (24 h) on CAL 27 and HepG2 cell lines. All of the applied MG extract concentrations seem to have a genoprotective effect on DNA plasmid. Furthermore, a significant inhibitory effect on E. coli was detected upon the treatment with 0.150 mg extract mL−1, reducing the cell viability by 56%.
A Simulation Analysis of the Stability of Tall and Collapse-Prone Stopes: A Case Study of the Dongguashan Copper Mine
Authors: Zhang Qinli , Huang Mingjian , Guo Jiang
Published: November 2024

This study conducts a simulation analysis of the stability of tall and collapse-prone stopes at the Dongguashan copper mine, using the FLAC3D-3.0 software to investigate the stress distribution and deformation behavior of geological materials under different working conditions, providing an effective means of addressing complex mechanical issues in geotechnical engineering. In this paper, the stability of the tall stopes in the Dongguashan mining area was analyzed through numerical simulations using the FLAC3D finite difference method. First, a three-dimensional numerical model of the tall stopes was established based on the actual conditions of the mining area, simulating the mining conditions and environment. Next, the stress distribution, displacement variation, and potential instability zones under different mining schemes were studied, with a comparative analysis conducted between traditional mining methods and optimized schemes to clarify their respective advantages and disadvantages. Finally, based on the simulation results, the most suitable mining scheme for the area was identified, aimed at reducing the risk of stope collapse and improving the overall stability and safety of the mine. The findings provide technical support for the design and support of tall stopes in deep deposits and offer important reference points for mine safety management.
Modal Parameters Estimation of Circular Plates Manufactured by FDM Technique Using Vibrometry: A Comparative Study
Authors: Hagara Martin , Pástor Miroslav , Lengvarský Pavol , Palička Peter , Huňady Róbert
Published: November 2024

This paper presents a comparative study focused on a modal parameters estimation of specimens manufactured by the FDM technique using a fixed embedded vibrometer based on the laser Doppler principle and roving hammer-impact method. Part of this paper is devoted to testing a fixed circular plate with a honeycomb infill pattern while varying the number of excitation points (DOFs), the number of analysis lines of fast Fourier transformation (FFT), and the locations or numbers of reference degrees of freedom (REFs). Although these parameters did not significantly affect the values found for the natural frequencies of the structure, there were changes in the estimates of the mode shapes (affected by the low number of DOFs), in the height and sharpness of the peaks of the CMIF functions (caused by the increased number of FFT lines), and in the number of identified modes (influenced by the chosen location(s) of REFs), respectively. Subsequently, the authors compared the results of experimental modal analyses carried out under the same conditions on three circular plates with honeycomb, star, and concentric infill patterns made of PLA. The results confirm that specimens with honeycomb or star infill patterns have a higher stiffness than those with concentric infill patterns. The low values of the damping ratios obtained for each structure indicate a strong response to excitation at or near their natural frequencies.
Incremental Nonlinear Dynamics Inversion Control with Nonlinear Disturbance Observer Augmentation for Flight Dynamics
Authors: Kim Lamsu , Kim Jeong I.
Published: November 2024

A flight controller formulation based on incremental nonlinear dynamics inversion (INDI) control with nonlinear disturbance observer (NDO) is proposed. INDI control is a nonlinear controller based on incremental dynamics. Aimed to attain robustness for nonlinear dynamics inversion (NDI)-based controller, incremental dynamics are derived using the first-order Talyor series expansion to nonlinear systems. The incremental dynamics-based controller requires information on state derivative terms to strengthen the robustness property of the nonlinear controller. The proposed controller utilizes the first-order low-pass filter to obtain the state derivative estimate to implement incremental dynamics into the system. Because the incremental form creates uncertainty term which is an aftermath of the Taylor series expansion, the proposed controller adopts the NDO to eliminate this effect. The controller is applied to the generic transport model which was developed by NASA for simulation purposes. The proposed NDO-based INDI control underwent simulations, together with an INDI controller without disturbance observer, and showed that the developed method results in better performances, providing important advantages where it compensates the uncertainties, removes the steady-state error, and shows less oscillating longitudinal body rate response than the baseline controller, desirable for aerodynamics applications with faster system response.
Modeling and Dynamic Characteristics of Tracked Vehicle Equipped with Symmetrical Suspensions Based on Multi-Body Dynamics and Discrete Element Coupling Method
Authors: Tao Jing , Deng Zhiyuan , Cao Xiuquan , Hu Guangzhong , Wang Ping
Published: November 2024

For improving the adaptability of a tracked vehicle equipped with a symmetrical suspension system on complex hilly terrain, based on the coupling method of multi-body dynamics (MBD) and discrete element method (DEM), an MBD-DEM coupling model was built and verified to explore its dynamic behaviors on soil. Firstly, according to the basic parameters of the tracked vehicle equipped with a symmetrical suspension system, a corresponding MBD model was built in Recurdyn V9R4 software. Based on the Euler–Lagrange method, the mathematical structure of the symmetrical suspension system was analyzed, and a corresponding mathematical simulation model was built in Matlab2016/Simulink to verify the MBD model. Secondly, based on the DEM theory and the parameter of the soil in a hilly area, a granular pavement model was built. Then, based on the coupling method of MBD and DEM, the corresponding MBD-DEM coupling model was built. Finally, using the MBD-DEM coupling model, the dynamic behaviors of the tracked vehicle equipped with a symmetrical suspension system under horizontal condition, the climbing condition and the obstacle crossing condition were obtained and discussed. The study results show that the proposed MBD-DEM coupling model could be used effectively to analyze the dynamic characteristics of the tracked vehicle. In addition, according to the analysis of the dynamic characteristics of the proposed tracked vehicle, the tracked vehicle equipped with a symmetrical suspension presents good adaptabilities under various working conditions.
Optimization of Wiring Harness Logistics Flow in the Automotive Industry
Authors: Popa Cicerone Laurentiu , Iorga Ioana , Cotet Costel Emil , Ifrim Ana Maria , Popescu Constantin-Adrian , Dobrescu Tiberiu Gabriel
Published: November 2024

This paper presents a compelling argument for optimizing the logistics flow of wiring harnesses within the automotive industry to address the rising production demands of vehicle manufacturers. It introduces an innovative assembly line structure specifically designed to boost efficiency and enhance responsiveness to client needs. Drawing from data gathered from an actual assembly line dedicated to producing engine harnesses for K9K engines, this study offers a practical and impactful foundation for its proposed optimization strategies. The new assembly structure effectively merges the benefits of a dynamic line—which emphasizes efficient space utilization and flexibility—with the strengths of a rotary line, particularly in light of the increasing complexity associated with harness production. The paper features a mathematical model that calculates cycle times for workstations within this new system architecture, optimizing the entire production process. Moreover, it illustrates how advanced modeling, simulation, and optimization techniques using WITNESS Horizon Version Release 25.0 can identify necessary adjustments for achieving optimal assembly line balance. Additionally, this research addresses pressing environmental concerns by proposing a robust recycling strategy for the scrap produced during wiring harness manufacturing. By advocating for sustainable practices and responsible waste management, the study highlights the importance of minimizing the ecological footprint of the automotive manufacturing process. In summary, this research provides essential insights and practical solutions for optimizing wiring harness logistics flow in the automotive industry. By implementing these strategies, manufacturers can significantly enhance their production capacity, improve operational efficiency, and maintain competitiveness in an ever-evolving market landscape.