bluuebunny/crossref_metadata_2025 huggingface dataset:
Difference Analysis of White, Red, and Grey Sufu: Crosstalk between Metabolomics, Proteomics, and Microbiomics
Authors: Zhang Chenning , Li Ying , He Tao , Sun Mo , Shao Yuanyang
Published: September 2024

The present study aimed to systematically analyse the differences in metabolites, proteins, and the microbiota among white sufu (WS), red sufu (RS), and grey sufu (GS) by integrating multi‐omics detection techniques. First, the various metabolites in sufu were identified through widely targeted metabolomics. Then, differential proteins in sufu were screened, and the principal functions of differential proteins were further mined using proteomic techniques. Finally, the microbiota in the sufu were analysed via 16S rRNA sequencing technology to observe differences in the microbial composition. The results showed that approximately 306 metabolites were present in the three kinds of sufu. Among them, there are 448 differential metabolites in RS and WS, 412 differential metabolites in WS and GS, and 517 differential metabolites in RS and GS. A total of 4663 proteins were identified. Among them, 448 differential proteins were found in RS and WS, 412 differential proteins were identified in WS and GS, and 517 differential proteins were detected in RS and GS. Approximately 77 types of microbes were distributed among three kinds of sufu. The population of WS is mainly distributed with 55.3% of protobacteria and 42.5% of Firmicutes. Proteobacteria and Firmicutes were the dominant microbial phyla common to the three kinds of sufu: the dominant bacteria in WS, RS, and GS were Enterobacter, Pantoea, and Kluyveromyces. The integrative crosstalk of multi‐omics analysis illustrated that the metabolites, proteins, and microorganisms in sufu are closely interrelated and together produce unique amino acids in different kinds of sufu.
Functional, Antioxidant Activity and Thermal Characteristics of Nutritious Snacks Containing Almond Processing By‐Products
Authors: Hashemi Neda , Milani Elnaz
Published: September 2024

Extrusion cooking was performed to evaluate the use of agroindustrial and food waste for the development of functional snacks. Almond (Amygdalus communis L.) oil cake (AOC), which is a by‐product of oil extraction, is rich in antioxidants and protein and fiber contents. The effects of extrusion conditions, feed moisture content (12–16%), screw speed (120–220 rpm), and AOC replacement (10 : 30%) on antioxidant activity, TPC, SME, functional properties, and melting enthalpy were investigated. WAI, WSI, and SME of the extrudates decreased with the addition of AOC, while the antioxidant activity, TPC, melting enthalpy, and SDF increased with the increase of AOC content. Increasing the screw speed had negative effects on the antioxidant activity and TPC and positive effects on the WSI, SME, and SDF of the snacks. Optimum extruded products were obtained at an AOC content of 28%, a moisture content of 12%, and a screw speed of 120 rpm screw speed with 0.876 desirability. Thus, puffed products containing AOC would be a nutraceutical food that is a good source of phenolic components.
Figure S18 from HPN328, a Trispecific T Cell–Activating Protein Construct Targeting DLL3-Expressing Solid Tumors
Authors: Molloy Mary E. , Aaron Wade H. , Barath Manasi , Bush Mabel C. , Callihan Evan C. , Carlin Kevin , Cremin Michael , Evans Thomas , Guerrero Maria G. , Hemmati Golzar , Hundal Avneel S. , Lao Llewelyn , Laurie Payton , Lemon Bryan D. , Lin S.J. , O’Rear Jessica , Patnaik Purbasa , Sotelo Rocha Sony , Santiago Linda , Strobel Kathryn L. , Valenzuela Laura B. , Wu Chi-Heng , Yu Stephen , Yu Timothy Z. , Anand Banmeet S. , Law Che-Leung , Sun Liping L. , Wesche Holger , Austin Richard J.
Published: September 2024

Transient changes in counts of white blood cells, lymphocytes, neutrophils, and monocytes associated with single dose intravenous administration of HPN328 to cynomolgus monkeys.
Table S1 from IL-15/IL-15Rα-Fc-Fusion Protein XmAb24306 Potentiates Activity of CD3 Bispecific Antibodies through Enhancing T-Cell Expansion
Authors: Li Ji , Clark Robyn , Slaga Dionysos , Avery Kendra , Liu Ke , Schubbert Suzanne , Varma Rajat , Chiang Eugene , Totpal Klara , Bernett Matthew J. , Holder Patrick G. , Junttila Teemu T.
Published: September 2024

Supplementary table S1 shows the effects of XmAb24306 on EC50 of TDB in vitro killing
Supplementary Figure S1 from Crizotinib Enhances PARP Inhibitor Efficacy in Ovarian Cancer Cells and Xenograft Models by Inducing Autophagy
Authors: Santiago-O’Farrill Janice M. , Blessing Bollu Alicia , Yang Hailing , Orellana Vivian , Pina Marc , Zhang Xudong , Liu Jinsong , Bast Robert C. , Lu Zhen
Published: September 2024

Supplementary Figure S1 shows CI values and IC50 of Olaparib and Olaparib/crizotinib
Supplementary Figure S2 from USP44 Overexpression Drives a MYC-Like Gene Expression Program in Neuroblastoma through Epigenetic Reprogramming
Authors: Ekstrom Thomas L. , Hussain Sajjad , Bedekovics Tibor , Ali Asma , Paolini Lucia , Mahmood Hina , Rosok Raya M. , Koster Jan , Johnsen Steven A. , Galardy Paul J.
Published: September 2024

Adrenergic or Mesenchymal identities do not reliably correlate with USP44 status.
Supplementary Figure S13 from USP44 Overexpression Drives a MYC-Like Gene Expression Program in Neuroblastoma through Epigenetic Reprogramming
Authors: Ekstrom Thomas L. , Hussain Sajjad , Bedekovics Tibor , Ali Asma , Paolini Lucia , Mahmood Hina , Rosok Raya M. , Koster Jan , Johnsen Steven A. , Galardy Paul J.
Published: September 2024

USP44 loss alters H3K27ac at distal regions.
Figure S6 from Clinically Relevant Humanized Mouse Models of Metastatic Prostate Cancer Facilitate Therapeutic Evaluation
Authors: Kostlan Raymond J. , Phoenix John T. , Budreika Audris , Ferrari Marina G. , Khurana Neetika , Choi Jae E. , Juckette Kristin , Mahapatra Somnath , McCollum Brooke L. , Moskal Russell , Mannan Rahul , Qiao Yuanyuan , Vander Griend Donald J. , Chinnaiyan Arul M. , Kregel Steven
Published: September 2024

Metastasis by 22Rv1 to the heart in huNOG and huNOG-EXL mice.
Figure S4 from MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer
Authors: Meena Jitendra K. , Wang Jarey H. , Neill Nicholas J. , Keough Dianne , Putluri Nagireddy , Katsonis Panagiotis , Koire Amanda M. , Lee Hyemin , Bowling Elizabeth A. , Tyagi Siddhartha , Orellana Mayra , Dominguez-Vidaña Rocio , Li Heyuan , Eagle Kenneth , Danan Charles , Chung Hsiang-Ching , Yang Andrew D. , Wu William , Kurley Sarah J. , Ho Brian M. , Zoeller Joseph R. , Olson Calla M. , Meerbrey Kristen L. , Lichtarge Olivier , Sreekumar Arun , Dacso Clifford C. , Guddat Luke W. , Rejman Dominik , Hocková Dana , Janeba Zlatko , Simon Lukas M. , Lin Charles Y. , Pillon Monica C. , Westbrook Thomas F.
Published: September 2024

Figure S4 shows DIS3L mutation in human tumors, evolutionary action score of tumor-derived mutation in DIS3L, genomic alteration of MYC and DIS3L in human breast cancer, expression of DIS3L mRNA in human breast tumors, and expression of genes in ribonucleotide catabolism and synthesis upon DIS3L knockdown.
Supplementary Table S9 from A Functional Survey of the Regulatory Landscape of Estrogen Receptor–Positive Breast Cancer Evolution
Authors: Barozzi Iros , Slaven Neil , Canale Eleonora , Lopes Rui , Amorim Monteiro Barbosa Inês , Bleu Melusine , Ivanoiu Diana , Pacini Claudia , Mensa’ Emanuela , Chambers Alfie , Bravaccini Sara , Ravaioli Sara , Győrffy Balázs , Dieci Maria Vittoria , Pruneri Giancarlo , Galli Giorgio Giacomo , Magnani Luca
Published: September 2024

Supplementary Table S9: SIDP results in LTED. S9.1: results of the differential abundance analysis for the positive controls and the non-targeting sgRNAs. The structure of the table is like S3.1. S9.2: results for the sgRNAs targeting the genomic regions of interest. The structure of the table is like S3.2.
Supplementary Methods and Note from Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis
Authors: Demajo Santiago , Ramis-Zaldivar Joan E. , Muiños Ferran , Grau Miguel L. , Andrianova Maria , López-Bigas Núria , González-Pérez Abel
Published: September 2024

Supplementary Methods and Supplementary Note
Supplementary Figure S18 from A Functional Survey of the Regulatory Landscape of Estrogen Receptor–Positive Breast Cancer Evolution
Authors: Barozzi Iros , Slaven Neil , Canale Eleonora , Lopes Rui , Amorim Monteiro Barbosa Inês , Bleu Melusine , Ivanoiu Diana , Pacini Claudia , Mensa’ Emanuela , Chambers Alfie , Bravaccini Sara , Ravaioli Sara , Győrffy Balázs , Dieci Maria Vittoria , Pruneri Giancarlo , Galli Giorgio Giacomo , Magnani Luca
Published: September 2024

Supplementary Figure 18. SIDV design and results.
Data from Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis
Authors: Demajo Santiago , Ramis-Zaldivar Joan E. , Muiños Ferran , Grau Miguel L. , Andrianova Maria , López-Bigas Núria , González-Pérez Abel
Published: September 2024

Abstract
Clonal hematopoiesis (CH) is a phenomenon of clonal expansion of hematopoietic stem cells driven by somatic mutations affecting certain genes. Recently, CH has been linked to the development of hematologic malignancies, cardiovascular diseases, and other conditions. Although the most frequently mutated CH driver genes have been identified, a systematic landscape of the mutations capable of initiating this phenomenon is still lacking. In this study, we trained machine learning models for 12 of the most recurrent CH genes to identify their driver mutations. These models outperform expert-curated rules based on prior knowledge of the function of these genes. Moreover, their application to identify CH driver mutations across almost half a million donors of the UK Biobank reproduces known associations between CH driver mutations and age, and the prevalence of several diseases and conditions. We thus propose that these models support the accurate identification of CH across healthy individuals.

Significance: We developed and validated gene-specific machine learning models to identify CH driver mutations, showing their advantage with respect to expert-curated rules. These models can support the identification and clinical interpretation of CH mutations in newly sequenced individuals.

See related commentary by Arends and Jaiswal, p. 1581
Supplementary Data from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer
Authors: Benej Martin , Hoyd Rebecca , Kreamer McKenzie , Wheeler Caroline E. , Grencewicz Dennis J. , Choueiry Fouad , Chan Carlos H.F. , Zakharia Yousef , Ma Qin , Dodd Rebecca D. , Ulrich Cornelia M. , Hardikar Sheetal , Churchman Michelle L. , Tarhini Ahmad A. , Robinson Lary A. , Singer Eric A. , Ikeguchi Alexandra P. , McCarter Martin D. , Tinoco Gabriel , Husain Marium , Jin Ning , Tan Aik C. , Osman Afaf E.G. , Eljilany Islam , Riedlinger Gregory , Schneider Bryan P. , Benejova Katarina , Kery Martin , Papandreou Ioanna , Zhu Jiangjiang , Denko Nicholas , Spakowicz Daniel
Published: September 2024

Numbers at risk for the association between low and high hypoxia in COAD and READ tumors (associated with the Kaplan-Meier curve shown in Figure 1D).
Supplementary Data from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer
Authors: Benej Martin , Hoyd Rebecca , Kreamer McKenzie , Wheeler Caroline E. , Grencewicz Dennis J. , Choueiry Fouad , Chan Carlos H.F. , Zakharia Yousef , Ma Qin , Dodd Rebecca D. , Ulrich Cornelia M. , Hardikar Sheetal , Churchman Michelle L. , Tarhini Ahmad A. , Robinson Lary A. , Singer Eric A. , Ikeguchi Alexandra P. , McCarter Martin D. , Tinoco Gabriel , Husain Marium , Jin Ning , Tan Aik C. , Osman Afaf E.G. , Eljilany Islam , Riedlinger Gregory , Schneider Bryan P. , Benejova Katarina , Kery Martin , Papandreou Ioanna , Zhu Jiangjiang , Denko Nicholas , Spakowicz Daniel
Published: September 2024

Differences in the immune cell populations, estimated by RNAseq, within high and low hypoxia mouse tumors, combining the nude and BALB/c mice.
Supplemental Figure S2 from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer
Authors: Benej Martin , Hoyd Rebecca , Kreamer McKenzie , Wheeler Caroline E. , Grencewicz Dennis J. , Choueiry Fouad , Chan Carlos H.F. , Zakharia Yousef , Ma Qin , Dodd Rebecca D. , Ulrich Cornelia M. , Hardikar Sheetal , Churchman Michelle L. , Tarhini Ahmad A. , Robinson Lary A. , Singer Eric A. , Ikeguchi Alexandra P. , McCarter Martin D. , Tinoco Gabriel , Husain Marium , Jin Ning , Tan Aik C. , Osman Afaf E.G. , Eljilany Islam , Riedlinger Gregory , Schneider Bryan P. , Benejova Katarina , Kery Martin , Papandreou Ioanna , Zhu Jiangjiang , Denko Nicholas , Spakowicz Daniel
Published: September 2024

Boxplots comparing immune fractions in low and high hypoxia groups in the ORIEN radiation cohort, displaying cells with significantly different abundance with an adjusted p-value <0.05.
Treatment of a Complex Case of Scleromyxedema Using a Novel Intravenous Immunoglobulin Preparation
Authors: Vollmer Anastasia Sophie , Wiedenmayer Nadine , Winkler Julia K. , Enk Alexander H.
Published: September 2024

Introduction: We provide a case report on a patient with scleromyxedema treated with high-dose intravenous immunoglobulins (IVIgs) who reported less fatigue and fewer headaches after transitioning to Yimmugo, a novel IVIg preparation. Scleromyxedema is a rare and chronic cutaneous mucinosis, frequently associated with monoclonal gammopathy and systemic complications, which may be life-threatening. The disease is characterized by papular eruptions and sclerosis of the skin. Treatment of scleromyxedema is challenging because of its unclear pathogenesis. High-dose IVIgs are a promising treatment option to improve cutaneous manifestations. Case Presentation: We present the case of a 57-year-old patient with scleromyxedema and monoclonal gammopathy with end-stage renal failure on hemodialysis (3 times a week). Stabilization of skin symptoms was finally achieved by high-dose IVIg therapy administered at 2 g per kg bodyweight distributed over 2 days every 3 weeks. However, disease stabilization came at the expense of flu-like side effects that significantly affected daily life. After transitioning to Yimmugo®, the patient reported an improved quality of life. Conclusion: Further follow-up is essential to conclusively evaluate effectiveness and tolerability of this novel IVIg preparation.
Influence of Carnatic Vocal Training on Voice Measures in Males
Authors: Sreeparvathi Athickal , Sheela Shekharaiah , Aithal Venkataraja Udupi
Published: September 2024

Introduction: Training is an integral part of learning any skill. The vocal training helps singers attain proficiency as they are the most demanding vocal group of all professional voice users. Hence, it is necessary to evaluate the influence of training on the singer’s voice. The current study objective was to investigate the influence of vocal training on voice measures (acoustic and aerodynamic) between male Carnatic singers with lower (6 months–5 years) and higher (6–10 years) training using novel task “mkaram” along with lyrical task. Methods: Group 1 consisted of 30 trained male Carnatic singers with lower vocal training, and group 2, thirty trained male singers with higher training in the age of 18–45 years. The acoustic (frequency-related parameter, cepstral, spectral, perturbation, and noise) and aerodynamic measures (maximum phonation time and s/z ratio) of voice were obtained. The test-retest reliability was conducted on a sample of 10% of the population from each group, with a 2-week interval between the tests. Cross-sectional study design was applied. Results: The statistical analysis revealed significantly decreased frequency-related parameters (semitones) such as the mean fundamental frequency, lowest fundamental frequency, highest fundamental frequency at the low register and the highest fundamental frequency at the middle register in group 2 during “mkaram” task (p ≤ 0.05). Similarly, one of the spectral-related measures 1st harmonic-2nd harmonic (dB) during lyrical task and one of the noise-related measure harmonic-to-noise ratio (dB) at the middle register during “mkaram” task showed a significant decrease in group 2 compared to group 1 (p ≤ 0.05). Test-retest reliability revealed that most of the parameters had “acceptable to excellent” internal consistency (Cronbach’s α >0.7 to 1). Conclusion: Few frequency and noise measures during “mkaram” task and a spectral measure during lyrical task showed to be sensitive in distinguishing the impact of vocal training on the voices of male Carnatic singers. The higher vocal training was found to help the singers to perform more efficiently with enhanced vocal range particularly in the low register and to some extent in the middle register. Indeed, the study highlighted the positive effects of vocal training on male Carnatic singers.
Eye-Tracking-Based Cognitive Assessment Efficiently Detects Mild Cognitive Decline in the Predementia Stage
Authors: Katsuhisa Mizuki , Oyama Akane , Ito Yuki , Sugihara Nanami , Teshirogi Shin , Yamamoto Sho , Ikegawa Yuya , Nakajima Tsuneo , Nakatani Yoshitaka , Yamamoto Eriko , Bando Hiromi , Tanaka Sayaka , Hashimoto Mamoru , Iwata Kazuhiko , Takeda Shuko
Published: September 2024

Introduction: The early detection of cognitive decline is key to maximizing the benefits of preventive and therapeutic interventions against dementia. Generally, dementia is first assessed by interview-based neuropsychological tests, but the lengthy interview and mental stress during the assessment process make screenings inefficient. We previously developed a rapid screening test for dementia using an eye-tracking technology (eye-tracking-based cognitive assessment [ETCA]) and reported its utility for clinically detecting cognitive impairment in dementia cases. However, the ETCA’s performance in detecting people with mild cognitive decline, which is the major target population for dementia prevention strategies, remains insufficiently examined. Therefore, this study aimed to evaluate the ETCA’s performance in individuals aged 40 years and older (n = 94, mean age: 61.0 [SD 13.1] years) without being formally diagnosed with dementia. Methods: All participants underwent both the ETCA and neuropsychological tests, including the Mini-Mental State Examination (MMSE), Rivermead Behavioral Memory Test (RBMT), and Addenbrooke’s Cognitive Examination-III (ACE-III) on the same day. We examined the correlations in scores between the ETCA and each neuropsychological test. Furthermore, we selected participants who earned normal scores in each neuropsychological test and evaluated the ETCA’s performance in this subgroup. Results: Participants’ ETCA scores correlated significantly with their scores on neuropsychological tests, including the MMSE, RBMT, and ACE-III. Notably, the ETCA scores correlated with the RBMT or ACE-III scores in individuals who showed normal scores in each neuropsychological test. Conclusion: The ETCA has the potential to screen mild cognitive decline efficiently at the predementia stage in nonclinical settings.
Impactos positivos dos Centros de Atenção Psicossocial Álcool e Drogas na qualidade de vida das pessoas
Authors: Araujo Renato de Angelo , Ballan Caroline , Boska Gabriella de Andrade , Claro Heloísa Garcia , Santos Ligia Bugelli Hermano , Oliveira Marcia Aparecida Ferreira de , Pinho Paula
Published: September 2024

O aparato internacional dos direitos humanos contribuiu para a transformação do modelo psiquiátrico no Brasil. A partir da década de 1980, a reforma psiquiátrica brasileira impulsionou a construção de um modelo de atenção à saúde mental comunitária. Este artigo teve como objetivo avaliar os serviços de saúde mental, com vistas a contribuir para a qualificação da Rede de Atenção Psicossocial, identificar problemas e impulsionar o aprimoramento das práticas e políticas públicas de saúde. Tratou-se de uma pesquisa avaliativa, descritiva, de caráter quantitativo, parte do projeto matricial “Avaliar CAPS AD” (Centro de Atenção Psicossocial Álcool e Drogas). Foram avaliados serviços dos estados de São Paulo, Minas Gerais e Amapá na perspectiva dos gestores dos serviços. Os dados foram analisados à luz do conjunto de ferramentas “QualityRights”, da Organização Mundial da Saúde, em relação ao acesso e garantia de direitos e os resultados foram estruturados a partir dos 20 padrões propostos nos cinco temas desse conjunto. Dentre a totalidade, 15 serviços atingiram alcances parciais e totais de qualidade na garantia e respeito aos direitos e foram encontradas algumas fragilidades importantes, avaliadas como padrões não iniciados, como a escassez de propostas de geração de renda ou a necessidade de ampliação dos Centro de Atenção Psicossocial Álcool e Drogas III – 24 horas. Os resultados demonstraram ainda a potência dos serviços comunitários e territoriais no exercício da cidadania de direitos.
O refletir sobre a morte na escrita de si em Rita Lee: outra autobiografia
Authors: Coelho Luana da Silva
Published: September 2024

Resenha do livro Rita Lee: outra autobiografia.
Cenário
Authors: Rodrigues André Luiz dos Santos
Published: September 2024

Creative writing.
Um fantoche feito de olhos
Authors: Silva Rayssa Cristina da
Published: September 2024

The four short stories presented were selected among the literary creations produced in my Programmed Research Activity carried out in 2023 to complete my degree at Unifesp. The research is entitled "Returning to writing fiction: saying grief, death and the fantastic". The texts chosen for publication in the magazine are those that seek to express elements of horror with fantasy, creating a process of metamorphosis of ideas that conflict with reality.
Faz de conta: patriarcado e ambiguidade no capítulo 36 de São Bernardo, de Graciliano Ramos, e em “Nada e a nossa condição”, de Guimarães Rosa
Authors: Alves Vinícius Cardoso
Published: September 2024

For a long time, it was believed that Brazil, after the 1930 Revolution and the Juscelino Kubitscheck Government, had achieved the basic premises of a Rule of Law. However, the integration of the country's poor masses, who remained far from citizenship, did not seem to be part of the reforms and liberal promises contained in the developmental campaigns of both periods. In other words, remnants of colonial sociability seemed to be integrated into the country's modernization, which took on peculiar contours. The representation of this complex process that lasted three centuries seems to be present in the make-believe of Paulo Honório, protagonist of the novel São Bernardo (1934), by Graciliano Ramos, and Tio Man'Antônio, hero of “Nothing and our condition”, a short story from the book First stories (1962), by Guimarães Rosa, they create to reform themselves and the world, suggesting more egalitarian sociability. Thus, this article analyzes how the fictionalization of reforms by two representatives of the order counteracts the nonconformities of the social process of private accumulation and assimilation of poor free men in different historical moments of the Nation.
Introdução ao misticismo na ficção de Campos de Carvalho
Authors: Ferreira Arthur Barboza
Published: September 2024

In this article, I present a study about the mystical facet of Campos de Carvalho’s fiction. I give a bird’s eye view of it in 7 narratives: Tribo, A lua vem da Ásia, “Os trilhos”, Vaca de nariz sutil, A chuva imóvel, O púcaro búlgaro, and Espantalho habitado de pássaros. I show, throughout this literary corpus, some features that can be qualified as mystical. The mystical facet that I highlight here is defined by a contrast with conventional religiosity. One of the features of this facet is a quest for self-knowledge. This quest is accompanied by a feeling of estrangement in relation to the world, pictured as a realm where time and death reign. These 2 features are intertwined with a longing for transcendence which, in several of these narratives – i.e., Vaca de nariz sutil, A chuva imóvel, and O púcaro búlgaro – is linked to the union with a woman, an “earthly salvation by means of the feminine.”
A presença do insólito na literatura policial e suas manifestações em Crimes à moda antiga: contos verdade, de Valêncio Xavier
Authors: Leszczynski Taynara
Published: September 2024

Este artigo tem como objetivo principal discutir a presença do insólito na literatura policial. Embora, inicialmente, essa questão possa ser vista como problemática, levando em consideração que corresponde a um gênero bastante conectado à realidade, ela se sustenta pelo não entendimento do insólito apenas como um mero sinônimo de sobrenatural, mas sim como um termo capaz de abranger diversas narrativas que causem estranhamento por abordarem acontecimentos inusuais. Para entender melhor esse apontamento e aprofundar a discussão, analisaram-se as manifestações do insólito em Crimes à moda antiga: contos verdade, de Valêncio Xavier, um livro composto por oito contos que abordam oito casos criminais reais, ocorridos no Brasil no século XX. Para definir o conceito de insólito, o trabalho pautou-se nas contribuições de García (2007) (2014); e, para estudá-lo no gênero policialesco, nas ideias de Todorov (1981) e Lovecraft (2007). Assim, foi possível compreender que o insólito na literatura policial se constitui por meio da ambiguidade, ele é uma alusão ao sobrenatural, não uma confirmação dele. Portanto, essa vertente não abandona a verossimilhança e ainda realça a atmosfera de tensão das narrativas, ressignificando-as.
Threat Impairs the Organization of Memory Around Motivational Context
Authors: Horwath Elizabeth A. , Katerman Brandon S. , Biju Meryl , DuBrow Sarah , Murty Vishnu P.
Published: September 2024

Previous work highlighted a critical role for top–down goals in shifting memory organization, namely, through studying the downstream influences of event segmentation and task switching on free recall. Here, we extend these frameworks into the realm of motivation, by comparing how threat motivation influences memory organization by capturing free recall dynamics. In Study 1, we manipulated individuals' motivation to successfully encode information by the threat of exposure to aversive sounds for forgetting. In Study 2, we conducted a parallel study manipulating motivation via instruction rather than threat, allowing us to examine changes directly related to threat motivation. Our findings showed that motivation to avoid threat broadly enhances memory for items presented within a threatening context, regardless of whether items were directly associated with the threat or not. Concurrently, these memory enhancements coincide with a decrease in the organization of memory around motivationally relevant features. These results highlight the importance of considering motivational valence when conceptualizing memory organization within adaptive memory frameworks.
Chiloschista eckhardii (Orchidaceae, Aeridinae), a new miniature leafless orchid from northern Vietnam
Authors: DANG MINH QUAN , AVERYANOV LEONID V. , MAISAK TATIANA V. , WOOK UM SUNG , CANH NGUYEN VAN , PHAN XUAN THUY , TRUONG QUANG TAM , WOJTAS K. PHILIP , TRUONG BA VUONG
Published: September 2024

Chiloschista eckhardii, discovered recently in Ha Giang Province of northern Vietnam, is described as a new species to science. The newly discovered species belongs to group of plants having yellow sepals and petals spotted with dark brown marks. Our newly identified species may be misidentified as C. glabrisepala, C. parishii, or C. quangdangii, which share a similar hairy band on the central callus of the lip, whereas this feature is glabrous in other related species. The new species differs from the similar species mentioned in having a callus that is slightly shorter than the median lobe and a densely hairy median part of the lip callus. In contrast, C. glabrisepala has a callus that is as long as or slightly longer than the median lobe, with hairs only on the apex of the disc callus. C. parishii has a callus shorter than the median lobe, with the lip disc and callus entirely hairy, while C. quangdangii has a distinctly shorter callus that is densely hairy. This paper presents the description of the new species, along with data on its habitat and phenology, a color plate detailing the flower structure, and notes comparing it with similar species.
Two new combinations in Pitardella (Rubiaceae) and first record of the genus in the Malay Peninsula
Authors: CHEN JUNHAO , NG XIN YI , WONG KHOON MENG
Published: September 2024

Two new combinations viz. Pitardella kelantansis and Pitardella mussaendoides are made. Previously, the two taxa were variously assigned to Randia, Tarenna and Porterandia. The key differences between these genera are briefly discussed. In addition, a lectotype is designated for Pitardella mussaendoides.
An endemic species flock of Candonidae Kaufmann, 1900 (Crustacea, Ostracoda) from wells in Benin (Africa), with the description of a new subfamily, a new genus and five new species
Authors: HOTÈKPO SOUROU JOSEPH , SCHÖN ISA , MARTENS KOEN
Published: September 2024

Between 2015 and 2022, over 200 wells were sampled in four catchment areas of Benin, using both Cvetkov plankton nets (funnel 200 µm mesh size, 150 µm below valve) and baited traps. As artificial wells serve as ecotones (interfaces between surface and groundwater ecosystems), the ostracod fauna is mostly represented by two families; Cyprididae (mainly epigeic) and Candonidae (hypogeic). Here, we describe a new subfamily of Candonidae from the wells in Benin, the Benincandoninae subfam. nov. Hotèkpo & Martens, represented by one genus, Benincandona gen. nov. Hotèkpo & Martens. We found 35 species belonging to this evolutionary radiation, of which we describe five new species: Benincandona martini gen. et spec. nov. Hotèkpo & Martens, B. ibikounlei gen. et spec. nov. Hotèkpo & Martens, B. sakitii gen. et spec. nov. Hotèkpo & Martens, B. cebios gen. et spec. nov. Hotèkpo & Martens and B. trapezoides gen. et spec. nov. Hotèkpo & Martens. The new subfamily and genus are characterised by a unique combination of characters, such as a seven-segmented antennula and a caudal ramus with a fully developed ramus, a single apical (anterior) claw and three short setae. Species within the genus can be distinguished by their carapace and hemipenis morphology, together with some limb characteristics. Whereas extensive subterranean candonid radiations have previously been reported from Europe, North and Central America and Northwest Australia (Pilbara), this is the first time such a vast radiation of subterranean candonids is reported from (West) Africa.
Transforming the Legacy of Colonial and Racialized Inequities in Childcare Systems in the United States: (Re)Framing Futures Through Black Feminist Thought
Authors: Harmon Flora , Salazar Pérez Michelle
Published: September 2024

Early Childhood Education and Care (ECEC) and childcare systems in the United States have been grounded in colonial and racist origins and capitalistic frameworks, and continue to contribute to contemporary inequities. In this article, we suggest a reframing of ECEC, one inspired by Black feminist thought that problematizes economic rationales for childcare, and the devaluing of educator knowledges, especially educators of color. Through a discussion of Black Feminist Care and professional learning as one site of transformation, we illustrate how Black feminisms can uproot oppressive systems, disrupting and transforming childcare in a way that is anti-racist and equitable.
The culture of care to enhance laboratory animal personnel well-being: a scoping review
Authors: Morahan Heidi L , Cohen Shari , Bero Lisa , Rooney Kieron B
Published: September 2024

There has been intense focus on improving the quality of animal research in recent times. An emerging concept of a ‘culture of care’ has been proposed as another important pillar to enhance scientific quality, with staff well-being being a critical aspect. Professionals working with research animals can face moral and psychological burdens and are at risk of experiencing work-related stress. However, data on the global prevalence of stress in this population is limited. Equally, it is not clear how these stresses manifest, and what impact they might have on an individual’s workplace performance and research quality. The purpose of this review was to identify work-related stress, its prevalence, and map evidence on strategies to mitigate stresses. We also set out to identify studies assessing the association between work-related stress and research quality. A systematic search was conducted across four databases, in addition to hand searching relevant references. We included peer-reviewed publications describing work-related stress, culture of care and laboratory animal professionals. A total of 49 publications were included for data mapping. Compassion fatigue was the most frequently described work-related stress, and its prevalence across Europe and North America is likely to be widespread. Multiple strategies to mitigate compassion fatigue and work-related stress were put forward, however, limited empirical evidence was available to assess success. Moreover, no studies reported empirical data linking work-related stress with research quality, despite several publications stating the case. Further population-specific research and measured assessments are urgently needed to deliver culture of care programmes to improve human well-being, animal welfare and research quality.
“They Slow Me Down”: Peer Relationships, School Fights, and the Criminalization of Black Adolescent Development Through School Discipline Policies
Authors: Hill Alizé B. , Harper Toyan
Published: September 2024

We sought to understand the school and legal experiences of “at-risk youth”. Twenty-six semi-structured interviews were conducted with Black adolescents (aged 15–19) participating in a youth program. Based on a narrative analysis, three core narratives emerged—(a) school staff and family members as motivating school success; (b) unsupportive peer relationships that “slow youth down”; (c) the occurrence and recurrence of school fights. Youth identified their families, school staff, and elementary school friends as their support network. In contrast, new high school peer relationships were identified as the underlying cause of school fights. Zero-tolerance school discipline policies enacted after a school fight (suspensions, arrests, and transfers to alternative schools) perpetuated and sustained conflict between students. Using abolition and ecological systems as a theoretical lens, this study provides a conceptual model identifying school fights as a major mechanism of the school-prison nexus and offers recommendations for school social workers.
Guiding missiological research the symbiotic relationship between academic excellence, flexible research process design and praxis-focused research output
Authors: Oxbrow Mark
Published: September 2024

Research is a lifelong journey for those who are called to give contextually potent witness to the Christian gospel. Doctoral programmes provide an excellent training in research method as well as producing new knowledge and thought that can be highly significant for the strengthening of Christian witness in many contexts but this paper will argue that the doctoral thesis is not the only, or always, the most appropriate, format for the presentation of missional research. Reflecting on the first six years of the Oxford Centre for Mission Studies’ Guided Research Programme the paper suggests that those concerned for more effective Christian witness globally need to explore a new approach to research that presents new knowledge and academic challenge to a wider audience, facilitating participation in research by greater numbers of church leaders, agency workers and Christian academics without compromising academic excellence. The article suggests priorities for such a development.
Forgiveness, power, and gender in a chinese Context
Authors: Yih Caroline
Published: September 2024

Even though forgiveness is a universal aspect of humanity, the conceptualisation, experience, and enactment of forgiveness diverge in significant ways across the broader socio-political and cultural divides as well as in situational and personal contexts. This article examines the practice of forgiveness under the array of shaping impacts from the Chinese cultural traditions and worldviews through the frameworks of collectivism and power distance (PD) to draw attention to the implicit but profound influence power holds in Chinese forgiveness. It draws attention to how power can cause concerning complications in forgiveness for one group of such individuals—women in Chinese contexts. In presenting the special relationship between power and forgiveness in the collectivistic Chinese culture, the article aims to foster discussion of the importance of understanding the full process of forgiveness in groups with little access to power, and to promote culturally-specific research in investigating such a process.
Construction and verification of a risk prediction model for cognitive frailty in older patients with chronic obstructive pulmonary disease and diabetes mellitus
Authors: Liang Meng-yao , Li Rui , Feng Li , Qian Wei-peng
Published: September 2024

Objective

We explored risk factors for cognitive frailty in older patients with chronic obstructive pulmonary disease (COPD) and diabetes mellitus to develop and verify a risk prediction model for cognitive frailty.

Methods

This was a cross-sectional study. Convenience sampling was used to randomly select 378 patients hospitalized between February 2022 and December 2023. We allocated 265 patients who visited between February 2022 and February 2023 to a modeling group to analyze risk factors for cognitive frailty and create a logistic regression model for risk prediction. Another 113 patients who visited between March 2023 and December 2023 were included in a validation group for model verification.

Results

The cognitive frailty incidence in the 265 patients was 35.09% (93/265). Regression analysis showed that age >80 years (odds ratio [OR] = 4.576), regular exercise (OR = 0.390, polypharmacy (OR = 3.074), depression (OR = 2.395) duration of COPD combined with diabetes (OR = 1.902), Family APGAR index score (OR = 0.428), and chronic pain (OR = 2.156) were factors influencing the occurrence of cognitive frailty in older patients with COPD accompanied by diabetes.

Conclusions

The constructed risk prediction model for cognitive frailty in older patients with COPD and diabetes showed good predictive value, aiding in the clinical identification of high-risk patients and facilitating timely intervention and guidance.
GABA(A) Receptor Subunit (γ2, δ, β1-3) Variants in Genetic Epilepsy: A Comprehensive Summary of 206 Clinical Cases
Authors: Zhu Xinyi , Li Peijun
Published: September 2024

Epilepsy is identified in individuals who experienced 2 or more unprovoked seizures occurring over 24 hours apart, which can have a profound impact on a person's neurobiological, cognitive, psychological, and social well-being. Epilepsy is considerably diverse, with classifications such as genetic epilepsy that result directly from a known or presumed genetic variant with the core symptoms of seizures. The GABAA receptor primarily functions as a heteropentamer, containing 3 of 8 subunit types: α, β, γ, δ, ε, π, θ, and ρ. In the adult brain, the GABAA receptor is the primary inhibitory component in neural networks. The involvement of GABAA receptors in the pathogenesis of epilepsy has been proposed. We extensively reviewed all relevant clinical data of previously published cases of GABAA receptor subunit γ2, δ, β1-3 variants included in PubMed up to February 2024, including the variant types, loci, postulated mechanisms, their relevant regions, first onset ages, and phenotypes. We summarized the postulated mechanisms of epileptic pathogenesis. We also divided the collected 206 cases of epilepsy into 4 epileptic phenotypes: genetic generalized epilepsies, focal epilepsy, developmental and epileptic encephalopathies, and epilepsy with fever sensibility. We showed that there were significant differences in the likelihood of the γ2, β2, and β3 subunit variants causing genetic generalized epilepsies, focal epilepsy, developmental and epileptic encephalopathies, and epilepsy with fever sensibility. Patients with the β3 subunit variant seemed related to an earlier first onset age. Our review supports that GABAA receptor subunit variants are a crucial area of epilepsy research and treatment exploration.
Totalitarian Law and Communal Ghettoisation: An Arendtian Perspective
Authors: Zuberi Fahad , Susewind Raphael
Published: September 2024

How are legal institutions and frameworks exploited to create ghettoised communities in contemporary India? Across three case studies – the Disturbed Areas Act in Gujarat, the ‘bulldozer justice’ phenomenon of 2022, and the BJP's electoral ‘land jihad’ rhetoric – we argue that law, far from being a liberal bulwark against majoritarianism, increasingly comes to encapsulate raw power, unencumbered by either morality or fact. We theorise this phenomenon through Hannah Arendt's argument that the seeds of totalitarianism lie in the hollowing-out, depoliticising effect of ‘juridification’, paving the way for totalitarianism to fill the affective void. But what happens to law once the threshold to totalitarianism is crossed? In contemporary India, we argue, the depoliticising, technocratic kind of law that Arendt described is not the only legal pathology; we also witness the emergence of a novel kind of hyper-politicised, performative, signalling, ultimate meaningless law that she didn’t quite anticipate. It is the dialectic between these two legal pathologies – juridification as bureaucratisation and hyper-politicised signalling – that cements Muslim Indians’ increasingly precarious ghettoisation.
Percentage mammographic density or absolute breast density for risk stratification in breast screening: Possible implications for socioeconomic health disparity
Authors: Hudson Sue , Kamangari Nahid , Wilkinson Louise S
Published: September 2024

Objectives

Obesity levels and mortality from breast cancer are higher in more deprived areas of the UK, despite lower breast cancer incidence. Supplemental imaging for women with dense breasts has been proposed as a potential improvement to screening, but it is not clear how stratification by percentage mammographic density (%MD) would be reflected across socioeconomic groups. This study aims to clarify the associations between breast composition (dense and fatty tissue) and socioeconomic status in a multi-ethnic screening population.

Methods

Demographic characteristics were collected for 62,913 participants in a UK breast screening programme (age, ethnicity, Index of Multiple Deprivation (IMD)). Automated mammographic measurements were derived: dense volume (DV), non-dense volume (NDV) and percent density (%MD). Correlations between deprivation and mammographic composition were examined before and after adjustment for age, ethnicity and NDV, using non-dense breast volume as a proxy for body mass index (BMI).

Results

There was negligible correlation between deprivation and DV (r = 0.017; P < 0.001 in all cases), but NDV increased with increasing deprivation (Pearson r = 0.101). Correlations were weaker in the Asian and Chinese ethnic groups. %MD decreased with deprivation (r = −0.094) and adjustment for ethnicity did not alter the association between %MD and IMD (relative change, most to least deprived quintile IMD: 1.18; 95% confidence interval: 1.16, 1.21).

Conclusions

Deprivation-related differences in %MD in the screening population are largely explained by differences in breast fat volume (NDV) which reflects BMI. Women in more deprived areas, where obesity and breast cancer mortality rates are higher, have increased breast adiposity and may miss out on risk-adapted screening if stratification is based solely on %MD or BIRADS classification.
“I Want to Be a Better Person and a Better Teacher”: Exploring the Constructs of Race and Dis/ability in a Music Educator Collaborative Teacher Study Group
Authors: Knapp Erika J.
Published: September 2024

The purpose of this collective case study was to examine a collaborative teacher study group (CTSG) that explored narratives of race and dis/ability in music education. Participants were eight public school music educators from across the United States. The group met 11 times in Fall 2021, completed three individual interviews, and wrote in a private online journal. Initially, participants displayed a broad spectrum of agreements and dissonances between their words and actions regarding race and ability. At the end, participants described changes resulting from participation in the CTSG, including becoming more aware of the ways that racism and ableism operated in their teaching and personal lives. Primary factors that contributed to change were building connections with other music teachers, experiencing emotional intensity, space and time to grapple with difficult materials, as well as the structure of the CTSG. I offer implications and recommendations for practice.
Factors Associated With Sacubitril/Valsartan Continuation and the Methods of Combining Heart Failure Medications in Patients With Heart Failure
Authors: Iwasaki Erika , Kohyama Noriko , Inamoto Mayumi , Nagao Michiru , Sunaga Tomiko , Suzuki Hiroshi , Ebato Mio , Kogo Mari
Published: September 2024

Background:

Sacubitril/valsartan (SV) is recommended for patients with heart failure (HF). In addition, a combination of 4 HF medications, including SV, is recommended in patients with HF with reduced ejection fraction (HFrEF). However, evidence on the characteristics of patients who could continue SV and its initiation methods is limited.

Objective:

To investigate the factors associated with SV continuation and methods of combining HF medications.

Methods:

This retrospective cohort study included HF patients who initiated with SV at our institution. The endpoint was SV continuation for 6 months after its initiation. Multivariate analysis was used to extract factors associated with SV continuation. The relationship between the methods of combining HF medications (renin-angiotensin system inhibitors, beta-blockers, mineralocorticoid receptor antagonists, or sodium-glucose cotransporter 2 inhibitors), including the number of HF medications, their combination patterns, and the timing of their initiation, and SV continuation was examined in patients with HFrEF.

Results:

Of 186 eligible patients, 68.8% had HFrEF, and 79.0% continued SV for 6 months. Significant factors associated with SV continuation were albumin ≥ 3.5 g/dL (odds ratio, 4.81; 95% confidence interval, 2.19-10.59), body mass index (BMI) ≥ 18.5 kg/m2 (4.17; 1.10-15.85), and systolic blood pressure (SBP) ≥ 110 mmHg (2.66; 1.12-6.28). In patients with HFrEF, the proportion of HF medications not initiated simultaneously with SV was significantly higher in the continuation group than in the discontinuation group (67.3% vs 33.3%, P = 0.002). The number of HF medications and their combination patterns were not significantly associated with SV continuation.

Conclusion and Relevance:

Albumin, BMI, and SBP are useful indicators for selecting patients who are likely to continue SV. In addition, initiating only SV without simultaneously initiating other HF medications in patients with HFrEF may lead to SV continuation.