bluuebunny/crossref_metadata_2025 huggingface dataset:
Impacto en la calidad del agua de la quebrada "El Atajo" ocasionado por el botadero de rondón de la ciudad de Chachapoyas, Amazonas, Perú
Authors: Mego Rojas Junior , Pilco Culque Jhoward , Chavez-Ortíz Jhesibel , Leiva-Tafur Damarís , Oliva Manuel
Published: April 2023

La presente investigación buscó determinar el impacto de la inadecuada disposición final de residuos sólidos de la ciudad de Chachapoyas en el sector Rondón sobre la calidad del agua de la quebrada "El Atajo", en base a parámetros fisicoquímicos y microbiológicos. Los resultados obtenidos fueron comparados con los Estándares Nacionales de Calidad Ambiental para Agua (ECAs). La investigación se desarrolló en épocas de avenida y en estiaje, estableciendo estaciones de muestreo en zonas estratégicas. Se evaluaron parámetros fisicoquímicos in situ como temperatura, pH, oxígeno disuelto y conductividad eléctrica; en laboratorio se determinaron parámetros como sólidos totales disueltos, sólidos suspendidos totales, demanda química de oxígeno, demanda bioquímica de oxígeno, nitratos, nitrógeno amoniacal y dureza total. A su vez se determinaron parámetros microbiológicos como Coliformes totales y Coliformes termotolerantes o fecales.Los resultados de los análisis arrojaron valores de alto riesgo por la presencia de Coliformes termotolerantes yColiformes totales con niveles de concentración superiores a 1600 NMP/100 ml. Asimismo cabe destacar que la Demanda Bioquímica presentó el nivel de concentración más alto de 15,3 mg/L en época de estiaje.
Fitogeografía y morfología de los Vaccinium (Ericaceae) “arándanos nativos” del Perú
Authors: Mostacero León José , Rázuri González Tatiana , Gil Rivero Armando Efraín
Published: April 2023

Las ericáceas de los géneros Vaccinium, Cavendishia y Pernettya poseen frutos que son consumidos local y regionalmente por diferentes comunidades andinas. Dentro de estos géneros, Vaccinium tiene un gran potencial agroindustrial, a raíz del hallazgo de las propiedades alimenticias y antioxidantes de sus bayas. Esto ha ocasionado que el consumo de sus bayas haya aumentado, considerándose elemento fundamental en las dietas a nivel mundial. En esta ocasión se desarrolló una búsqueda de información accediendo a bases de datos y registros especializados, lo cual permitió conocer las especies del género Vaccinium del Perú, con datos de su ﬁtogeografía y morfología. Este trabajo reporta 13 especies de Vaccinium, entre ellas: V. amazonicum, V. decipiens, V. corymbodendron, V. crenatum, V. dependens, V. didymanthum, V. ﬂoribundum, V. mathewsii , V. pseudocaracasanum, V. elvirae , V. ortizii, V. sphyrospermoides, V. youngii.
Performances of cryo-treated and untreated cutting tools in machining of AA7075 aerospace aluminium alloy
Authors: ADİN Mehmet Şükrü
Published: April 2023

The quality of drilled holes in aluminium alloys used in the aerospace industry is vital to ensure high-precision structural integrity. For this reason, optimum selection of cost-effective cutting tools and cutting parameters is of great importance. Nowadays, due to their high cost and supply difficulties, there is a great interest in improving the performance of traditional HSS cutting tools as an alternative to ceramic, carbide and coated cutting tools. HSS cutting tools are widely used in different industries due to their cost-effectiveness and suitability to improve tool performance. In this research, the performances of cryo-treated (DC&T) and untreated (UT) HSS cutting tools used in dry machining of AA7075 aluminium alloys were investigated. Thanks to DC&T processes applied to HSS cutting tool, improvements have occurred in its microstructure. The hardness value of HSS cutting tool increased by 6.89% with the effect of DC&T processes applied. When the highest and lowest Ra values obtained using DC&T and UT HSS cutting tools were compared, it was seen that DC&T HSS cutting tool performed better by 11.05% and 25.91%, respectively. It has been determined that the hole surface quality of the aluminium workpiece machined with DC&T and UT HSS drills is negatively affected by the increase in spindle speed and feed rate. The highest S/N ratios calculated according to Ra values of holes drilled on aluminium workpieces using DC&T and UT HSS cutting tools were found to be -7.12 dB (2.27 μm) and -9.62 dB (3.03 μm), respectively. In the ANOVA analysis, it was determined that the most effective parameters on Ra values were spindle speed (70.62%), tools (18.19%) and feed rate (9.98%), respectively. In the regression analysis, R2 value for Ra values was calculated as 98.30%. High R2 value result shows that the model developed is quite successful in estimating Ra values.
Pénfigo por IgA
Authors: Garcia Virginia , Corbal Melisa Valeria , Garay Iliana Stella
Published: April 2023

El pénfigo por inmunoglobulina A (IgA) es un trastorno ampollar crónico y poco frecuente, caracterizado por la presencia de autoanticuerpos IgA contra los desmosomas. Se reconocen dos variantes principales: dermatosis pustulosa subcórnea (DPS) y dermatosis neutrofílica intraepidérmica (DNIE). El diagnóstico se basa en las características clínicas y se confirma mediante la histología y presencia de depósitos de IgA entre los queratinocitos.La dapsona es el tratamiento de primera línea. En este reporte presentamos un paciente con DNIE, que respondió inicialmente al tratamiento con corticoides vía oral y dapsona. El interés de este reporte es revisar de modo sintético los rasgos más importantes de esta entidad poco frecuente.
¿Reconoce esta clave diagnóstica?
Authors: Gallego Leydi , Rodríguez Estupiñán Aura Catherine , Jaimes Ramirez Angel Omar
Published: April 2023

Los tumores dolorosos de la piel son un reto diagnóstico para el médico dermatólogo por su evolución insidiosa e inespecífica. Estas lesiones son poco frecuentes correspondiendo aproximadamente al 2% de los tumores de tejidos blandos cutáneos, además se acompañan de síntomas dolorosos neuropáticos, destacándose la alodinia como síntoma cardinal. A continuación, se describe el caso de un paciente masculino de 76 años que presentó un tumor doloroso solitario de localización poco frecuente en el tercio distal de antebrazo derecho tratado quirúrgicamente. De esta manera se resolvió el dolor asociado y mejoró su calidad de vida.
Respeto por el colega
Authors: Maya Mejía José María
Published: April 2023

Presentación del caso de un médico especialista, que solicita al director del hospital se revise su asignación salarial, porque ha encontrado que esta es igual a la de otros especialistas y él considera que es injusto, dado que las actividades que realiza en la institución son más complejas y producen más estrés que las llevadas a cabo porsus colegas.El médico director lleva el caso a estudio por parte de la comisión de personal del hospital y del comité de ética hospitalaria. Ambos comités estudian la solicitud y emiten el concepto al médico director para la toma de decisiones al respecto.
Se analiza el caso desde la perspectiva de ética médica y de las buenas prácticas en el manejo y la remuneración del talento humano en salud.
Sexually transmitted infections and mental health: Integrative review
Authors: Lucas Fernandes de Oliveira  , Louise Almeida Lima Freitas  , Maria Alix Leite Araújo  , Ana Fátima Braga Rocha  , Ana Karinne Dantas de Oliveira
Published: April 2023

Mental disorders increase the risk of developing diseases and lack of self-care, with Sexually Transmitted Infections (STIs) being one of the major causes of infection in this group. This study is an integrative review with the objective of answering the guiding questions: Which professional category is most public on the subject? What are the years of greatest publication? Which journal published the most on the subject? Which region has the largest number of publications on the subject? What is the population cited in the studies? Given the inclusion criteria, four articles were selected. Because it is a serious problem to be faced by professionals, as well as the need to advance in care and care practices for a comprehensive and positive care, aiming to reduce the incidence of STIs in this population.
Penerapan Keputusan Verstek di Pengadilan Agama
Authors: Darmawati Darmawati , Zainuddin Asriadi
Published: April 2023

Implementation of verstek decision in the Religious Court is one of the decision which handed down by the judges in the court. Verstek decision, is the decision which handed down because the absence of the defendant even though the defendant himself has been summoned by the proper and authorized. Verstek decision will be handed down after the parties were called and examined his case and examine whether the matters raised by the plaintiff it can be proved and the authority of the Religious Court. In the verdict verstek, then demand can be granted if the suit was groundless and did not fight right. But if the suit was groundless and or against the rights, the decision of the judge verstek a statement that the plaintiffs claim is not accepted, and if the claim is granted with verstek verdict, the defendant may seek such objection with verzet.
Problematika Mediasi di Pengadilan Agama Gorontalo dan Pengadilan Agama Limboto Tahun 2015
Authors: Faisal Ahmad
Published: April 2023

The integration of mediation in court practices, on the one hand intended to avoid the accumulation of cases, but on the other hand increase the burden of the judges. For that reason, it is understandable if the success rate is very small mediation divorce case. Paramediator limited time availability, lack of skills/skill mediator, lack of motivation and persistence finish the case, the absence of a mediator from outside the court registered a problematic instrument relating to the judge mediator. This condition presupposes the involvement of non-judge mediators, who have local knowledge base to engage in mediation cases. In fact, the regulations will it also looked very normative-procedural. In addition, this type of divorce case is rather complicated, especially if motivated by domestic violence, disharmony, the presence of third parties into its own problematic when mediated. But the most decisive is the parties who appeared since the beginning has been shut down to peace, making its implementation more complicated problems of mediation in Gorontalo Religious Court and Limboto Religious Court.
Relevansi Risalatu Al-Qada' Umar terhadap Etika Profesi Hakim di Indonesia
Authors: Kasim Dulsukmi
Published: April 2023

Professional ethics of a judge is something that is universal, meaning adopted, recognized, and found in the country's legal system, anytime and anywhere. That's because the problem was related to the problem of moral values, kindness, and decency which ideally is indeed the behavior and moral values that should always be held firmly by a who is a judge in performing their duties. In fact, it is not enough merely preserved, moral values are also always dibugarkan and developed in carrying out their duties. Relation risalatul al-qada' is very relevant to the professional ethics of judges in Indonesia because it contains in it the principle of the independence of judges in performing their duties; equality and fairness by not distinguishing between litigants; the principles of professionalism and has a personality that is unimpeachable; and the normative theological principles and peace.
Agama, Kiai, dan Nasionalisme
Authors: Fuad Andi Muhammad
Published: April 2023

Agama dan Negara di Indonesia sendiri merupakan sebuah bagian yang terpisah tapi bisa disatukan dengan merujuk kepada beberapa konsep yang ada sehingga Agama dan Negara khususnya Islam bisa disatukan dalam beberapa hal seperti suku, budaya, ataupun norma. Islam di Indonesia telah lama terkait dengan Negara karena ada beberapa unsur dalam Islam yang bisa diadopsi oleh Negara, contohnya tentang Nasionalisme dimana Islam memandang Nasionalisme sebagai bagian penting dalam pembentukan Negara Indonesia dan dimana Kiai berperan sebagai tonggak penting dalam menjalankan Nasionalisme di Indonesia. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian kualitatif dengan menggunakan pendekatan penelitian pustaka (library research), Metode penulisan dalam tulisan ini adalah metode kualitatif deskriptif yaitu mendeskripsikan suatu objek yang bersifat naratif, dengan pendekatan fenomenologi, yang berkaitan dengan fenomena agama, kiai, dan nasionalisme. Hasil penelitian menunjukkan bahwa relasi antara Agama, Kiai, dan Nasionalisme merupakan suatu relasi yang mempunyai peranan penting dalam membangun Negara sehingga kiai dianggap mempunyai peran penting dalam kemerdekaan Indonesia dan terbentuknya kontruksi social kiai tentang nasionalisme.
NIILISMO, CONHECIMENTO E ABSOLUTO EM FRIEDRICH H. JACOBI
Authors: Weber José Fernandes
Published: April 2023

O artigo apresenta os elementos filosóficos constitutivos da crítica, lançada por Jacobi a Fichte em sua Carta a Fichte, segundo a qual “Idealismo é niilismo”. Para tanto, reconstitui a crítica de Jacobi à pretensão idealista de estabelecer um sistema absoluto do conhecimento que, partindo da atividade originária e infinita do pensamento, põe a objetividade do mundo na medida em que o pensa; dá atenção à centralidade do problema do absoluto/de Deus na argumentação de Jacobi e sua relação com as noções de não-filosofia, não-saber e crença, além de apontar para as conexões destas noções com o emergente problema do niilismo na modernidade. Por fim, estabelece um breve contraponto com a filosofia de Nietzsche.
NIILISMO, SUICÍDIO E VALOR DA VIDA EM SCHOPENHAUER
Authors: Pavão Aguinaldo
Published: April 2023

O artigo propõe-se a apresentar e discutir o niilismo ínsito na filosofia de Schopenhauer. Defende-se uma necessária distinção entre dois tipos de niilismo, um que visa a afirmar verdades axiologicamente neutras sobre o mundo e a existência, outro que se compromete com uma tese valorativa que considera a negação da vontade o maior objetivo moral. O pessimismo metafísico, cuja tese básica consiste em arguir que a não existência é preferível à existência, incorpora os dois tipos de niilismo mencionados. O pessimismo schopenhaueriano tanto defende que toda vida é sofrimento quanto um caminho exclusivo para a redenção, a negação da vontade. Associados ao  niilismo e ao pessimismo estão os temas do valor (na verdade, desvalor) da vida e da reprovação do suicídio. A hipótese do artigo é que há deficiências consideráveis na filosofia schopenhaueriana em torno desses tópicos, especialmente a transição entre as teses descritivas e as teses valorativas que compreendem os dois momentos de seu niilismo.
O NIILISMO SEGUNDO O MODELO DE SÃO PETERSBURGO
Authors: Paschoal Antonio Edmilson
Published: April 2023

Se a expressão “niilismo russo” remete a uma ideia ampla e profundamente arraigada no contexto histórico e cultural em que surge, ao ser apropriada por Nietzsche, ela apresenta alguns traços bem peculiares, constituindo-se numa das principais fontes utilizadas pelo filósofo para matizar certas nuances de sua própria acepção de niilismo. Este artigo, circunscrito à apropriação feita por Nietzsche de algumas ideias de Ivan Turguêniev e Fiódor Dostoiévski, busca precisar justamente os momentos em que o conceito aparece nos escritos de Nietzsche e os papéis que exerce neles, conferindo uma atenção especial para uma forma ambivalente de niilismo que o filósofo chama de “niilismo segundo o modelo de São Petersburgo”.
O NIILISMO NAS MEMÓRIAS DO SUBSOLO: A CRÍTICA À RAZÃO COMO CRÍTICA À MODERNIDADE OCIDENTAL EM DOSTOIÉVSKI
Authors: Sabino Paulo Cesar Jakimiu
Published: April 2023

Este artigo propõe pensar a crítica de Dostoiévski à razão em Memórias do Subsolo como uma crítica contra a modernidade ocidental. Para isso, é necessário entender o contexto russo do século XIX e como ocorre uma espécie de “importação de ideias” da Europa ocidental para a Rússia, provocando no país as mesmas consequências da Europa, como o niilismo. Entende-se que o niilismo é um fenômeno moderno derivado das novas filosofias que emergem nesse período e, portanto, o niilismo ocorre também na Rússia, motivo pelo qual muitos autores, entre eles Dostoiévski, refletem sobre essa questão. Para compreender a crítica de Dostoiévski à modernidade, precisa-se levar em consideração que o niilismo não é apenas um “problema filosófico”, mas também possui uma dimensão social. Logo, a crítica é em relação à sociedade russa. Para a execução de tal proposta, toma-se de empréstimo a definição de niilismo de Franco Volpi a fim de estabelecer uma relação com o niilismo tal como se desenvolvia na Rússia.
HEIDEGGER E O IMPASSE DO NIILISMO DE NIETZSCHE
Authors: Fernandes Marcos Aurélio
Published: April 2023

A proposta desta reflexão é repensar como Heidegger se relaciona com o pensamento de Nietzsche a propósito da questão da essência do niilismo. Ela se volta para o volume 48 da Obra completa (Gesamtausgabe) de Heidegger – “Nietzsche: der europäische Nihilismus”. Após tematizar como Heidegger ouve a palavra de Nietzsche na história do pensamento ocidental, procura expor também sua resposta a esta palavra, salientando sobretudo os impasses que o pensamento do valor impõe no instante histórico para uma superação da metafísica.
Perencanaan Preventive Maintenance Mesin Crane Dengan Pendekatan Metode Reliability Centered Maintenance (RCM)
Authors: Nurroif Aufansyah , Retnowati Dini
Published: April 2023

Tingginya waktu downtime mesin crane di salah satu perusahaan manufaktur produsen baja billet menyebabkan terganggunya kelancaran proses produksi. Untuk mengatasi hal ini serta untuk mencapai kestabilan performa crane, maka perlu adanya tindakan perawatan yang intensif pada setiap komponen crane. Metode Reliability Centered Maintenance (RCM), digunakan untuk mengetahui interval waktu perawatan dan untuk mengetahui dampak positif dilakukannya perawatan terencana. Dari hasil penelitian diketahui bahwa ada 4 komponen kritis pada mesin Crane Abus yang perlu memperoleh prioritas tindakan perawatan dengan periode waktu interval perawatan untukmasing-masing komponen sebesar 44,5 jam untuk motor 3 phase, 13,6 jam untuk komponen brake, 149,16 jam untuk komponen MCB 1 Phase dan 101,69 jam untuk komponen. Dengan adanya tindakan perawatan terencana juga dapat memberikan penghematan biaya perawatan sebesar ± 88%.
Penerapan Metode Six Sigma dalam Menganalisis dan Menanggulangi Defect Rate pada Pengelasan Tubular
Authors: Febriansyah Febriansyah , Ilmi Nurul , Lawi Ansarullah
Published: April 2023

PT XYZ merupakan perusahaan general contractor untuk manufacturing, refinery, industrial, marine, oil and gas, yang menjalankan proyek welding tubular. Target untuk mencapai sasaran mutu perusahaan menjadikan PT XYZ selalu berusaha untuk mencapai dan menghasilkan produk yang berkualitas, aman, dan dapat memenuhi persyaratan pelanggan dengan harga yang kompetitif. Diketahui PT XYZ memiliki tingkat repair rate yang sangat tinggi berdasarkan record data per welder yang dilakukan pada pengujian ultrasonic test (UT). Hal ini sangat merugikan perusahan karena tingginya biaya dan waktu yang diperlukan untuk repair. Usaha untuk menurunkan defect rate hingga mencapai zero defect, dilakukan dengan menerapkan metode Six Sigma dalam sistem welding produksi. Tingkat proporsi defect yang terjadi dalam pengelasan tubular ini adalah sebesar 21% pada periode pengelasan selama 6 (enam) minggu.  Pada penelitian ini dilakukan 5 (lima) tahapan analisis six sigma yaitu DMAIC atau define, measure, analyze, improve dan control. Hasilnya diketahui penyebab terjadinya tingginya defect, hasil analisis, dan tindakan-tindakan yang perlu dilakukan dalam menanggulangi defect serta mengetahui nilai rata-rata sigma sebesar 3.30 setelah dilakukannya analisis.
Analisis Beban Kerja Menggunakan Metode Workload Analysis (WLA) Untuk Menentukan Kebutuhan Tenaga Kerja Optimal
Authors: Widhiarso Wahyu , Zein Nasyith Fahmi Ramadhani , Jatiningsih Maria Gratiana Dian
Published: April 2023

Terdapat suatu usaha manufaktur yang berjalan dibidang produk minuman jahe kemasan botol kaca. Dalam proses pengolahan produksi telah terjadi ketidaksamarataan beban kerja yang diterima oleh pekerja. Ketidaksamarataan ini dipengaruhi adanya aktivitas pada para pekerja yang berbeda-beda dari segi lamanya waktu pengerjaan. Penelitian ini dilakukan untuk mengetahui beban kerja dan menentukan kebutuhan jumlah pekerja optimal berdasarkan beban kerja pada bagian produksi sirup wedang jahe. Penelitian ini menggunakan workload analysis. Perhitungan waktu siklus menggunakan stopwatch time study yang dilakukan secara repetitive timing. Selain itu, ditentukan juga rating factor dan allowance pada setiap kegiatan proses yang dikerjakan oleh pekerja. Berdasarkan hasil perhitungan, maka didapatkan pada proses pencucian jahe diusulkan penambahan 1 pekerja, proses penggilingan dan penyaringan jahe diusulkan menambah 4 pekerja, sedangkan proses labeling dan pengemasan diusulkan penambahan 1 pekerja. Diagram fishbone digunakan untuk mengidentifikasi faktor-faktor penyebab beban kerja tinggi.
Review of modern ceramic cellular materials and composites used in heat engineering
Authors: Soloveva O. V. , Solovev S. A. , Shakurova R. Z.
Published: April 2023

THE PURPOSE. Cellular ceramic materials and composites have found application in many industries: energy, chemical industry, construction, aerospace. Due to their high thermomechanical properties, resistance to high temperatures and low density, cellular ceramic materials are widely used as heat exchangers for heat recovery from exhaust gases of gas turbine engines, combined-cycle plants, industrial furnaces, etc. The purpose of this work is to review modern cellular ceramic materials and composites used in heat engineering and having different structure, properties and chemical composition.

METHODS. We have carried out a broad review of the literature on ceramic cellular materials and composites. We studied both domestic and foreign literature.

RESULTS. The analysis of cellular ceramic materials with a regular (lattices) and random (foam) structure has been carried out. The main factors influencing the properties of ceramic foams and lattices are analyzed. Also, the main methods for the production of ceramic materials were studied, their advantages and disadvantages were revealed. A review of modern composite materials based on a ceramic matrix reinforced with carbon nanotubes, graphene nanoplates, and carbon fibers has been carried out.

CONCLUSION. The properties of ceramic cellular materials, as well as their areas of application, depend on the production methods and the structure of the material. Open-cell foams are used as filters, heat exchangers, while closed-cell foams are used as thermal insulation. Applications for ceramic lattices are limited by the precision, resolution, and size of 3D printing. Thus, the improvement of additive manufacturing technologies will improve the characteristics of ceramic gratings and expand their areas of application.
Age Differences in Social Inhibition among University Students and the General Population
Authors: Duijndam Stefanie , Lodder Paul , Karreman Annemiek , Kupper Nina
Published: April 2023

Background. Given the increased risk of socially inhibited (SI) individuals on internalizing psychopathology, insight into mean-level age and sex differences of adult SI is important since it may enhance our understanding of adaptive and maladaptive changes in SI across the lifespan. This study aimed to examine age differences in social inhibition (SI) and its underlying facets and whether these are moderated by sex. Methods. The 15-item Social Inhibition Questionnaire (SIQ15) was administered 847 undergraduate students (Mage=20.4±2.4; 72.4% women), and 2235 individuals from the general population (Mage=47.0±16.4; 50.1% women). Categorical CFA using means and variance-adjusted WSLMV estimation was fitted to replicate the previously identified three-factor social inhibition model. We estimated the differences in the latent higher order SI scores, compared the mean scores on the three latent SI facets between different age cohorts, subsamples, and sex, and investigated the moderation effect of sex on age cohort differences. Results. There were age cohort differences in SI, with highest levels in the youngest age group (<21 years old), and the lowest in age group 61-70 years old. Higher SI scores were observed in the oldest age group, which seems to be driven by higher interpersonal sensitivity and behavioral inhibition scores in older men. In addition, we found higher interpersonal sensitivity scores in the student population, and in women, and higher social withdrawal scores in men. Discussion. Overall, we found that across adulthood, social inhibition decreased. Establishing norm scores to timely identify potential problematic social inhibition levels related to psychopathology is warranted.
Modeling early phonetic acquisition from child-centered audio data
Authors: Lavechin Marvin , de Seyssel Maureen , Métais Marianne , Metze Florian , Mohamed Abdelrahman , Bredin Hervé , Dupoux Emmanuel , Cristia Alejandrina
Published: April 2023

Infants learn their native language(s) at an amazing speed. Before they even talk, their perception adapts to the language(s) they hear. However, the mechanisms responsible for this perceptual attunement and the circumstances in which it takes place remain unclear. This paper presents the first attempt to study perceptual attunement using ecological child-centered audio data. We show that a simple prediction algorithm exhibits perceptual attunement when applied on unrealistic clean audio-book data, but fails to do so when applied on ecologically-valid child-centered data. In the latter scenario, perceptual attunement only emerges when the prediction mechanism is supplemented with inductive biases that force the algorithm to focus exclusively on speech segments while learning speaker-, pitch-, and room-invariant representations. We argue these biases are plausible given previous research on infants and non-human animals. More generally, we show that what our model learns and how it develops through exposure to speech depends exquisitely on the details of the input signal. By doing so, we illustrate the importance of considering ecologically valid input data when modeling language acquisition.
Integrating word-form representations with global similarity computation in recognition memory
Authors: Osth Adam F , Zhang Lyulei R.
Published: April 2023

In recognition memory, retrieval is thought to occur by computing the global similarity of the probe to each of the studied items. However, to date, very few global similarity models have employed perceptual representations of words despite the fact that false recognition errors for perceptually similar words have consistently been observed. In this work, we integrate representations of letter strings from the reading literature with global similarity models. Specifically, we employed models of absolute letter position (slot codes and overlap models) and relative letter position (closed and open bigrams). Each of the representations was used to construct a global similarity model that made contact with responses and RTs at the individual word level using the linear ballistic accumulator (LBA) model (Brown & Heathcote, 2008). Relative position models were favored in three of the four datasets and parameter estimates suggested additional influence of the initial letters in the words. When semantic representations from the word2vec model were incorporated into the models, results indicated that orthographic representations were almost equally consequential as semantic representations in determining inter-item similarity and false recognition errors, which undermines previous suggestions that long-term memory is primarily driven by semantic representations. The model was able to modestly capture individual word variability in the false alarm rates, but there were limitations in capturing variability in the hit rates that suggest that the underlying representations require extension.
Caveat Medicus: It’s Time to Re-Think Stratification, You May Not Be Helping
Authors: Arandjelović Ognjen
Published: April 2023

The focus of the present article is on the large and seemingly fertile body of work captured under the umbrella of `patient stratification'. In particular, I identify and explain a fundamental methodological flaw underlying the manner in which the development of an increasingly large number of new stratification strategies is approached, showing an inherent conflict between the assumptions made, and the very purpose of stratification and its application in practice. The highlighted flaw is shown to undermine the overarching ultimate goal of improved patient outcomes by undue fixation on an ill-founded proxy. Hence, I issue a call for a re-think of the problem and the processes leading to the adoption of new stratification strategies in the clinic.
Pelatihan Manajemen Keuangan Vihara dalam Rangka Pengabdian Kepada Masyarakat Pada Anggota Magabudhi
Authors: Simbolon Sabam , Herijawati Etty , Wibowo Susanto , Susanti Metta , Limajatini  , Winata Suryadi , Sutandi  , Jenni
Published: April 2023

Pelaksanaan PkM ini melibatkan mitra kerjasama yaitu Magabudhi. Magabudhi sebuah organisasi massa kaum Buddha mazhab Theravada di Indonesia. Didirikan pada tanggal 3 Oktober 1976 di Bandung sebagai Mapanbudhi, pada Pasamuan Agung V tahun 1995 berganti nama menjadi Magabudhi. Peserta Magabudhi yang hadir pada saat acara berlangsung cukup ramai berkisar antara 30 sampai 35 orang. Pelaksanaan Pengabdian kepada Masyarakat (PKM) ini dilakukan pada hari Sabtu, tanggal 12 Nopember 2022 bertempat di gedung D Universitas Buddhi Dharma, Karawaci – Tangerang, Banten, 15115. Dengan adanya pelatihan ini diharapkan kedepannya para anggota Magabudhi yang didalamnya terdapat romo dan rahmani dapat mengerti pengelolaan keuangan Vihara khususnya umat Buddha yang ada di Indonesia. Dalam penulisan ini dapat disimpulkan bahwa manajemen keuangan di organisasi keagamanaan dalam hal ini Viharapun harus diatur dengan sebaik-baiknya, agar tujuan tercapai, kebutuhan terpenuhi dan menjadi pertanggungjawaban pengurus kepada para donatur.
Penyuluhan E-Commerce untuk Mendorong Ekonomi Digital Dalam Rangka Pengabdian Kepada Masyarakat pada Pemuda Tridharma Indonesia Cabang Wihara Dharma Pala
Authors: Kurnia Yusuf , Riki  , Giap Yo Ceng , Hermawan Aditiya , Gustayo Teven
Published: April 2023

Perkembangan  teknologi  informasi  di  era  revolusi  4.0  memberikan  dampak  yang signifikan terhadap perekonomian Indonesia. Platform digital dalam mendukung kegiatan perekonomian dan pemenuhan kebutuhan masyarakat bertumbuh dengan cepat dengan dukungan internet. dengan diterapkannya teknologi baru akan berdampak pada produkvitas dan menurunkan biaya produksi yang akan meningkatkan daya beli sehingga akan tercipta lapangan kerja baru. Metode kegiatan Pengabdian Kepada Masyarakat ini dilakukan melalui 4 tahapan (metode) yaitu metode sosialisasi, metode demonstrasi, metode praktek/latihan, evaluasi kegiatan. Pelaksanaan PkM ini melibatkan mitra kerjasama, yaitu Wihara Dharma Pala yang beralamat di Jl. Ir. Soekarno Kp, Jl. Raya Rawa Kompeni No.66, RT.003/RW.008, Benda, Kec. Benda, Kota Tangerang, Banten 15125. Tim pelaksana kegiatan Pengabdian kepada Masyarakat (PkM) terdiri dari 4 orang dosen & 1 orang mahasiswa. Tim dosen pelaksana Pkm terdiri atas dosen-dosen yang memiliki keterampilan & kemampuan dibidang teknologi informasi yang sesuai dengan tema PkM yang dilaksanakan serta memiliki kualifikasi akademik. Dari hasil hasil evaluasi yang dilakukan oleh Tim Pelaksana, dapat disimpulkan hal bahwa mayoritas peserta yang mengikuti kegiatan ini, sudah mengetahui tentang E-Commerce dan peserta masih kurang pengalaman dalam menggunakan layanan E-commerce seperti Market Place.
Synthesis, Cytotoxicity, Antibacterial and Antioxidant Activity of New 2-Substituted Benzimidazole Containing 1,2,4-Triazoles
Authors: Aryal Prateek , Shakya Bhushan
Published: April 2023

The development of a potent new drug with high biological activity is a challenge in drug design and is of strategic importance. Due to the increasing resistance of pathogens on the available drugs, there is always a demand for designing a potent drug with high biological activity. The pharmacological effects have been observed in compounds containing different moieties of pharmaceutical importance such as triazole, Schiff’s base, benzimidazole.Triazole thione, Schiff’s bases, and two new compounds containing three pharmacophores viz. triazole, benzimidazole, and Schiff base incorporated in a single compound were prepared by applying different synthetic reactions. Different spectroscopic methods, including FT-IR, UV-vis, 1H-NMR, and 13C-NMR, were used to confirm the structure of the prepared compounds. All compounds exhibited moderate antibacterial activity against Staphylococcus aureus (ATCC 6538P) and Staphylococcus epidermidis (ATCC 1228). Antioxidant activity was carried out by DPPH radical scavenging test and among the tested five compounds, the IC50 value of 4-amino-3-(2-hydroxyphenyl)-1H-1,2,4-triazole-5(4H)-thione was found to be 32.364 μg.mL-1 which is closer to the ascorbic acid that was found to be 28.546 μgmL-1. All tested compounds were toxic against brine shrimp where 2-(5-((1H-benzo[d]imidazol-2-yl)thio)-4-((4-chlorobenzylidene) amino)-4H-1,2,4-triazol-3-yl) was comparatively more toxic (LC50= 26.827 μgmL-1).
Comparative Phytochemical and Biological Study of Tinospora cordifolia (Thunb.) Miers and Justicia adhatoda L. Plants Collected from West Rukum of Nepal
Authors: Oli Biraj , Ghimire Gyanendra , Dhakal Bijay , Amatya Neetu , Adhikari Deepjyoti , Bhandari Netra Lal
Published: April 2023

Medicinal plants contained an impressive number of modern drugs and are believed to be a precious natural reservoir that has been continuously studied for its pharmacological activities against various ailments. Tinospora cordifolia and Justicia adhatoda are widely used shrubs in folk and ayurvedic systems of medicine. Phytochemical screening of different fractions of the extract of the bark of T. cordifolia and leaf, stem, and flowers of J. adhatoda was done and results show the presence of alkaloids, flavonoids, phenolics, glycosides, terpenoids in both plants. The antibacterial potency of medicinal plant extracts has been tested against Bacillus subtilis ATC6051 and Enterococcus faecalis ATCC29212 by disc diffusion assay. The leaves extract of J. adhatoda showed good antibacterial activities towards both the Enterococcus faecalis and Bacillus subtilis bacteria, however, the extract of T. cordifolia was found not soo effective with those bacteria. The methanol extract of T. cordifolia stem showed the strongest 2,2-diphenylpicrylhydrazyl (DPPH) radical scavenging activity with IC50 values 8.213μg/mL very close to standard ascorbic acid (22.451 μg/mL). Furthermore, results showed that T. cordifolia is a good source of antioxidants as compared to the J. adhatoda. The total phenolic content (TPC) was highest in methanolic extract of T. cordifolia (46.463 mg GAE/g extract) while the J. adhatoda had lower values (31.167 mg GAE/g extract) by taking gallic acid as a standard. The total flavonoid content (TFC) was highest in methanol extract of J. adhatoda leaves (13.030 mg QE/g extract) while T. cardifolia had lower values (2.112 mg QE/g extract) which were determined by taking quercetin as a standard. The result revealed that the TPC is higher in T. cordifolia and TFC value higher in J. adhatoda and that can be correlated with the antimicrobial and antioxidant properties of phytoconstituents although the plants have been used for the similar ethnomedical purpose in society.
Kinetics of Catalytic Oxidation of Carbenicillin: A Degradation Approach for Penicillanic Acid Derivatives (PADs)
Authors: Sahu Yuv Raj , Dev Rohit Kumar , Chaudhary Narendra Kumar , Bhattarai Ajaya
Published: April 2023

Diperiodatocuprate [DPC (III)] was selected to predict the kinetic studies for carbenicillin (CRBC) oxidation in the basic media. The investigation was completed in the presence of CoCl3 as catalyst by using a UV/Visible spectrophotometer at 298K temperature and 0.01 mol-dm-3 ionic strength which confirmed a 1:4 stoichiometry between CRBC and DPC (III). Both spectral and elemental analysis was used to identify the final products. Monoperiodatocuperate [MPC (III)] was found to be the primary active species of DPC (III). Pseudo-first order reaction was declared for DPC (III), while fractional order reactions were noticed in case of CRBC (substrate), Co (III) catalyst as well as KOH (alkali). However, for periodate, the reaction was determined to be in negative fractional order. Spectral evidence, determination of various rate constants, and both activation as well as thermodynamic parameters were used to predict plausible mechanism.
Entrepreneurial Intention of Management Graduates
Authors: Gaire Sanju , Upadhyaya Tara Prasad
Published: April 2023

The study analyzes the Entrepreneurial Intention of management graduates. Personal Attitude, Perceived Behavioral Control, Subjective Norms, Structural Support, and Entrepreneurship Education were used to explain the dependent variable–Entrepreneurial Intention. To fulfill the objective of this study, 240 primary data samples on a Likert scale were collected via. Digital communication platform. The data were then analyzed using descriptive statistics, independent t-test, one-way ANOVA, test and multiple regressions. The study showed that Personal Attitude, Perceived Behavioral Control and Subjective Norms had a positive significant impacted on Entrepreneurial Intention of management graduates. However, Structural Support and Entrepreneurship Education did not have significant impact on Entrepreneurial Intention.
Neurodegenrative changes in retina of rats with chronic epileptic syndrome under conditions of treatment with niacin-oxy-ethylidene-phosphonate germanate (MIGU-4)
Authors: Аль-Надаві Нора Джавад , Кресюн Валентин
Published: April 2023

Background:Epilepsy is accompanied by neurodegenerative changes, particularly those in the retina. Elucidation of the mechanisms of retinal alterations in a model of epileptic syndrome may allow for the development of new approaches to pharmacological vision correction. Purpose: To assess the morphological characteristics of the retina, particularly treated with niacin oxy-ethylidene phosphonate germinate (MIGU-4), in the pentylenetetrazole (PTZ)-induced kindling model of chronic epileptic syndrome. Material and Methods: PTZ was administered in Wistar male rats intraperitoneally (i.p.) at a daily dose of 35.0 mg/kg for 21 days. Rats with fully-developed generalized seizures were treated with MIGU-4 ip at a daily dose of 5.0 mg/kg or 25.0 mg/kg for 28 days. Thereafter, the animals were euthanized, their globes were enucleated, and retinal sections were prepared and stained with hematoxylin and eosin for morphological examination. Results: Cell density in the retinal ganglion cell layer was 2.14 times lower, and in the inner nuclear layer and outer nuclear layer, 41.0% and 19.0%, respectively, lower for the rats with fully developed kindled seizures than for controls (р less 0.05) In the presence of treatment with MIGU-4 ip at a daily dose of 25.0 mg/kg, cell density in the retinal ganglion cell layer and in the inner nuclear layer was 38% and 30,5%, respectively, higher than for controls (р less 0,05). There was no significant difference in the cell density in the outer nuclear layer between rats treated with MIGU-4 ip at a daily dose of 5 mg/kg or 25,0 mg/kg and controls (р more 0.05). Conclusion: The PTZ-induced kindling model of chronic epileptic syndrome is accompanied by degenerative changes in the eye. A course of treatment with MIGU-4 causes neuroptotective effects in a model of PTZ-induced retinopathy.
Precise in vivo adaptive optics imaging of retinal vessels
Authors: Задорожний Олег , Король Андрій , Насінник Ілля , Кустрін Тарас , Науменко Володимир , Пасєчнікова Наталія
Published: April 2023

Adaptive optics (AO) provides new, unique opportunities for in vivo visualization of retinal vasculature. AO retinal vessel imaging can be utilized as a component of multimodal imaging tools to complement conventional diagnostic imaging modalities. Non-invasive and highly promising AO imaging of fundus structures allows the qualitative and quantitative assessment of early signs of retinal vascular remodeling associated with age, arterial hypertension, diabetes mellitus and other disorders.
Device Application to Improve Patient Safety and Image Quality during Chest CT Examination of Unconscious Patients
Authors:   KOREA SOCIETY OF COMPUTED TOMOGRAPHIC TECHNOLOGY, Kim Seong-Min , Kim Yeun-ju , Choi Seong-Min , Lee Ki Baek
Published: April 2023

This study was to analyze the effect on patient safety and image quality improvement by lowering the arm and applying a self-made device during chest CT examinations of unconscious patients. From April 1 to September 30, 2022, 78 patients (male: 42, female: 36, mean age: 67 years old) among intensive care unit patients who underwent chest CT scan were retrospectively reviewed. The patients were classified into three positions as follows: both arms raised (A position), both arms straight out using the self-made device (B position), and both arms straight out to the side (C position). For radiation dose comparison, dose length product (DLP) values were measured and compared to each other. For image quality evaluation, image noise, signal to noise ratio (SNR), contrast to noise ratio (CNR), and contrast to dose ratio (CNRDR) values were compared, and qualitative evaluation was also performed. The average DLP value of the B position was significantly lower than that of the C position, and it was relatively higher than that of the A position, but there was no significant difference statistically.(p=0.051) In the quantitative evaluation, it was evaluated that the B position maintains a quality quite similar to that of the A position despite the lowering of the both arms. In addition, in the qualitative evaluation, an average score was obtained between A and C. In conclusion, it was confirmed that the use of the self-made device for rapid and safe chest CT examination of unconscious patients is useful in improving patient dose and image quality.
Conducting Evaluation Research with Hard-to-Follow Populations: Adopting a Participant-Centred Approach to Maximize Participant Retention
Authors: Fowler Heather Smith , Aubry Tim , Smith Marnie
Published: April 2023

Abstract: Longitudinal designs are effective for the evaluation of innovative social programs, but attrition can be a significant problem, particularly with hard-to-follow populations such as persons who are homeless. Tracking strategies for locating participants are essential, but retaining participants requires anticipating and addressing participants’ needs at every stage of the research. A strategy that emphasizes appropriate interviewer characteristics, the relationship between interviewer and participant, and participants’ “investment” in the research is critical. In other words, evaluation researchers can improve the retention of even hard-to-follow study participants by adapting research design and procedures to be “participant-centred.” An example is given of a program evaluation in Ottawa, Ontario, that implemented strategies to adapt to the needs of persons with severe mental illness and a history of homelessness.
The Experience of Developing a Package of Instruments to Measure the Critical Characteristics of Community Support Programs for People with a Severe Mental Illness
Authors: Rush Brian , Tate Ellen , Norman Ross , Kirsh Bonnie , Prosser Meghan , Wild T. Cameron , Lurie Steve
Published: April 2023

Abstract: A major challenge for program evaluators is to develop and use measures of program implementation that are both comprehensive and generalizable across programs. The goal is to understand how measures of program characteristics are related to outcomes and, ultimately, to improve program effectiveness. In this brief report, we describe our experience in developing a package of instruments to measure critical characteristics of community support programs for people with a severe mental illness. We highlight three primary methodological challenges encountered: ensuring comprehensiveness, attaining a common understanding of program boundaries, and incorporating multiple perspectives. Potential solutions are discussed. We conclude that, despite these challenges, the goal of model-free measures of program characteristics is essential to enable meaningful program comparisons and to substantiate important process-outcome links.
Using Web-Based Technologies to Increase Evaluation Capacity in Organizations Providing Child and Youth Mental Health Services
Authors: Sundar Purnima , Kasprzak Susan , Halsall Tanya , Woltman Heather
Published: April 2023

Abstract: Given today’s climate of economic uncertainty and fiscal restraint, organizations providing child and youth mental health services are required to do so with limited resources. Within this context, service providers face added pressure to deliver evidence-based programs and demonstrate program effectiveness. The Ontario Centre of Excellence for Child and Youth Mental Health works with organizations to meet these demands by building capacity in program evaluation. While personal instruction and mentoring are important ways of providing support, face-to-face consultations are not always cost-effective. In this article we describe the use of interactive technology and computer-based learning as an alternative and/or complementary (to face-to-face) means of delivering evaluation information and training. We discuss the process of developing these tools and share findings from our preliminary evaluation of their effectiveness in enhancing the evaluation-related supports we offer to providers of child and youth mental health services.
Efficacy and safety of antibody-drug conjugates in triple-negative and HER-2 positive breast cancer: A systematic review and meta-analysis of clinical trials
Authors: Afzal Fatima , Aiman Wajeeha , Zahoor Hafsa , Bajwa Ayfa Riaz , Kazmi Syeda Hafsa , Anwar Aqsa , Anwar Muhammad Yasir , Rashid Sana , Zubair Hina , Kashif Tooba , Ashar Ali Muhammad
Published: April 2023

Breast cancer (BC) is the 2nd most common cause of cancer-related deaths. Antibody-drug conjugates (ADCs) are monoclonal antibodies linked to cytotoxic agents and are directed towards a specific tumor protein. Therefore, they are more potent and can have relatively less toxicity. In this meta-analysis, we assessed the efficacy and safety of ADCs in breast cancer. We searched PubMed, Cochrane, Web of Science, and clinicaltrials.gov for relevant studies and included 7 randomized clinical trials (N = 5,302) and 7 non-randomized clinical trials (N = 658). R programming language software was used to conduct this meta-analysis. In 4 RCTs on HER-2 positive BC (N = 2,825), the pooled HR of PFS and OS was 0.72 (95% CI = 0.61–0.84, I2 = 71%) and 0.73 (95% CI = 0.64–0.84, I2 = 20%), respectively in favor of ADCs versus chemotherapy. In RCT on triple negative BC (N = 468), HR of PFS and OS were 0.55 (95%CI = 0.51–0.61) and 0.59 (95% CI = 0.54–0.66), respectively, in favor of saci-gov versus chemotherapy. In RCT on HER-2 positive residual invasive BC, HR of recurrence/death was 0.61 (95% CI = 0.54–0.69) in favor of ADC versus chemotherapy. In an RCT (N = 524), the HR of PFS and OS were 0.28 (95% CI = 0.22–0.37) and 0.55 (95%CI = 0.36–0.86), respectively, in favor of trastuzumab-deruxtecan (T-der) as compared to trastuzumab-emtansine (T-DM1). Anemia, rash, diarrhea, fatigue, hypertension, thrombocytopenia, and elevated aminotransferases were the common ≥grade 3 adverse events reported in 4%, 1%, 2%, 1%, 2%, 9%, and 3% of the patients, respectively. ADCs were more effective than single and double agent chemotherapy in patients with HER-2 positive or triple negative BC. Among ADCs, T-der was more effective than T-DM1.