bluuebunny/crossref_metadata_2025 huggingface dataset:
The Implementation and First-Round Results of a Community-Based Colorectal Cancer Screening Program in Shanghai, China
Authors: Gong Yangming , Peng Peng , Bao Pingping , Zhong Weijian , Shi Yan , Gu Kai , Zheng Ying , Wu Chunxiao , Cai Sanjun , Xu Ye , Sheng Jun , Wu Fan
Published: March 2018

Background

The incidence and mortality rate of colorectal cancer (CRC) have increased dramatically over the past 3 decades in China due to changes in lifestyle factors. Early detection and treatment guidelines for asymptomatic cases have shown to improve CRC control in developed countries. In response to these challenges, the Shanghai Municipal Government launched a community-based CRC screening program in 2012.

Materials and Methods

Free initial screening, inclusive of immunochemical fecal occult blood and risk assessment (questionnaire), was provided by community health centers in Shanghai. Participants with positive results were referred to a specialist for a colonoscopy.

Results

In 2013, 828,302 Shanghai residents were registered; 97.7% (809,528) of the registrants completed initial screening. Among 180,094 initial screening-positive participants, 71,733 underwent colonoscopy. The proportion of compliance to colonoscopy was 39.8%; the proportion decreased with age and educational level. A total of 6,668 adenomas were detected, and 1,630 CRC cases were diagnosed. The CRC detection rate of the program was 201.35/100,000; among the detected CRCs, 51.6% were in stage 0–I.

Conclusion

The screening program achieved great progress, especially on initial screening completion and CRC early stage rate, although particular intervention is still needed to improve the compliance of colonoscopy.

Implications for Practice

Due to socioeconomic transitions and lifestyle changes, colorectal cancer is now becoming one of the most common cancers in developing countries, as it is in developed countries. While most developed countries have now initiated national colorectal cancer screening programs based on recommended country-specific colorectal cancer screening guidelines, colonoscopy has become the most commonly used screening method. This is a challenge in developing countries due to limited resources. Based on the analysis of the Shanghai colorectal cancer screening program, with immunological fecal occult blood test and risk assessment as initial screening, followed by a diagnostic testing of colonoscopy for individuals with positive results, this article provides the basis and suggestion for similar program in other regions of China and other developing countries.
Bioinformatic pipeline for studying transcriptome and regulome dynamics during neural differentiation v3
Authors: Shang Zhouchun , Chen Dongsheng , Wang Quanlei , Wang Shengpeng
Published: March 2018

Here we present a bioinformatic pipeline for dissecting transcriptional regulation of neural differentiation process. Single cell RNA-seq and bulk ATAC-seq with two biological replicates was applied to the indicated cell stages including human induced pluripotent stem cells (hiPSCs), embryo body (EB), early rosettes (Ros-E), late rosettes (Ros-L), NPCs, and the original somatic fibroblasts (Fib) for a deeper understanding of the regulatory mechanisms driving the differentiation of the neural lineage. This pipeline could be applied to study transcriptome and regulome dynamics of other lineages.
Prescholers' causal reasoning v1
Authors: Van Schijndel Tessa
Published: March 2018

1 Protocol 2-5 Scoring forms (versions 1A, 1B, 2A and 2B) For communication regarding the translation of the documents the authors can be contacted.
Lattice Energies for Groups 1 and 2 Halides from Absolute Hardness
Authors: DE FARIAS Robson Fernandes , KAYA Savaş
Published: March 2018

In
this work, we presented new empirical equations to calculate the lattice energy
values of groups 1 and 2 halides based on absolute hardness values of cations
and anions forming the ionic compound.In
the given equations, r+ and r+2 = cation radius (pm); η+
and η+2 = cation absolute hardness (eV) and η- = anion
absolute hardness (eV). Here, it should be noted that calculated lattice energy
values for mentioned ionic compounds are in good agreement with the reference
values obtained from the literature.
A Fuzzy Logic Application for Explain Relationships Between 222Rn Concentration and Earthquakes
Authors: KAMIŞLIOĞLU Miraç
Published: March 2018

Earthquake
behaviors are, in general, among the non-linear topics of physics. Unfortunately
researches up to now could not yet propose a complete mathematical model for
earthquake behavior prediction possibilities. The main reason for not being
able to establish such a model is due to the non-linear behavior of the
earthquake and its generation is dependent on a variety of indigenous factors.
Mathematical expressions and modeling of the non-linear systems is
comparatively difficult and sometimes requires high speed and memory computers.
For this reason, the expert systems as Fuzzy Logic (FL) are now commonly used
for such modelling. Model is suggested a system to examine the
space-time behavior of any physical phenomena through a set of convenient
mathematical expressions, which describe linear or non-linear aspects. Fuzzy
logic applications have a fast increase in past few years. Fuzzy logic
modelling can be a very powerful explains about internal structure of dynamic
system. The most commonly used indicator in earthquake prediction studies is
soil radon gas (222Rn). In this study, we have tried to explain
relationships between 222Rn and earthquakes using fuzzy logic. The
application region is performed for 222Rn data of Mersin region near
the East Anatolian Fault System, Turkey.
Antibiotic sensitivity pattern of bacterial isolates from urine samples of admitted patients with urinary tract infection in a tertiary care teaching hospital of Tripura, India: a hospital record based study
Authors: Das Uttam K. , Bhattacharjee Prithul , Debnath Shubhaleena , Chakraborty Maitrayee , Ghosh Ranjib , Das Lakshman , Chakraborty Dipankar
Published: March 2018

Background: Urinary tract infection (UTI) being one of the most common and a serious health problem both in the community and hospital settings each year worldwide, the emergence of antibiotic resistance in the management of UTI is a serious public health issue. The present study will analyse the antimicrobial sensitivity pattern of pathogens isolated from the urine samples of admitted patients suffering from UTI in Tripura Medical College and Dr. B.R. Ambedkar Memorial Teaching Hospital (TMC).Methods: This was a hospital record-based study. The urine samples of clinically diagnosed UTI patients admitted in various departments of the hospital during the study period were included. The reports of culture and sensitivity testing of the samples were collected. The results were interpreted according to the guidelines of the Clinical and Laboratory Standards Institute (CLSI).Results: During the 12-month study period, a total of 752 urine samples were analysed. Enterococcus (43.75%) was the most frequently isolated bacteria, followed by E. coli (28.45%) and Klebsiella (14.89%). Enterococcus was highly sensitive (p<0.001) to vancomycin (95.33%), E. coli was mostly sensitive to nitrofurantoin (83.65%) and Klebsiella mainly sensitive to imipenem (75.49%).Conclusions: The study showed that positive urine culture with the antibiotic sensitivity of the isolates is very important for antimicrobial therapy, as antibiotic resistance is a worldwide problem which causes ineffectiveness of treatment.
Early Outcome of Treatment of Open Tibial Shaft Fractures Using External Fixators in Resource-Poor Setting
Authors: Abang Innocent E. , Asuquo Joseph E. , Anisi Chukwuemeka O. , Mpama Enagu A. , Onuba Obiora O. , Udosen Anthony M. , Ngim Ngim E. , Ikpeme Ikpeme A. ,   Department of Orthopedics and Traumatology, University of Calabar, Calabar, Nigeria.,   Department of Orthopedics and Traumatology, University of Calabar, Calabar, Nigeria.,   Department of Orthopedics and Traumatology, University of Calabar, Calabar, Nigeria.,   Department of Community Health, University of Calabar Teaching Hospital, Calabar, Nigeria.,   Department of Orthopedics and Traumatology, University of Calabar, Calabar, Nigeria.,   Department of Orthopedics and Traumatology, University of Calabar, Calabar, Nigeria.,   Department of Orthopedics and Traumatology, University of Calabar, Calabar, Nigeria.,   Department of Orthopedics and Traumatology, University of Calabar, Calabar, Nigeria.
Published: March 2018

To document the outcome of treatment in the first six months for open tibial shaft fractures managed with external fixators in resource-poor economy and the pattern of presentation of open tibial shaft fractures, a 12-month prospective observational study was conducted from January 2010 to December 2010. All the patients were recruited from the accident and emergency department of the University of Calabar Teaching Hospital. The demographic data of each patient, the type of injury, the mechanism of injury, and the outcomes were assessed. Moreover, 42 patients with open tibial shaft fracture were recruited for this study with forty (95.2%) patients successfully followed up for six months while two patients (4.8%) were lost to follow-up. Their ages ranged from 18 to 65 years with a mean age ± standard deviation of 33.5 ± 12.8 years. Majority of the patients (77.5%) were aged 20-50 years. There was a male to female ratio of 3:1. A total of 7 (17.5%) fractures healed after 20 weeks, Type IIIB fractures were 3 (7.5%), Type IIIA fractures were 4 (10%), but all Type II fractures had united between 12 and 15 weeks. The middle third fractures 9 (22.5%) had the highest number of fracture union within 16-20 weeks. The major cause of the injuries was from motorcycle accidents, which were 30 (75%), and others were from cars 7 (17.5%) and buses 3 (7.5%). This was largely due to the utilization of motorcycles as the major means of commercial transportation in the city until it was banned recently. However, they are still in use in the suburbs. The higher the Gustillo and Anderson grading of the open fracture of tibia, the more severe the wound and bone infection that occurred, and a significant interval between the injury time, wound debridement, and the time the external fixator was applied showed poor outcome for those who presented late (after two weeks of injury).
Abdominal Fat by Imaging Methods and Metabolic Syndrome in Young People
Authors: Rachid Novais Rommel Larcher , Corrêa Café Ana Carolina , Costa Bila Wendell , da Silva Santos Gilson Donizette , de Oliveira Lopes Carlos Alexandre , Caetano Romano Márcia Christina , Lamounier Joel Alves
Published: March 2018

Metabolic Syndrome is highlighted in the current health mainly due to its increasing prevalence in the world. Its occurrence among adolescents ranges from 2.2% to 51.7%. This set of diseases, when acquired during childhood/adolescence, tends to persist into adulthood. This study aims to present the results of the latest publications that correlated ultrasonography, computed tomography and magnetic resonance imaging with the components of the Metabolic Syndrome in young people. Nine papers were found. Abdominal adipose accumulation has a strong influence on the metabolic disorders of MS, being measurable by imaging methods. It is of crucial importance to deepen the knowledge of the benefits brought by the imaging tests and their relationship with the components of the syndrome so that clinicians and radiologists can use these exams, especially in young people, where an accurate and early diagnosis allows interventions that will influence reducing the risk unfavorable outcomes in adult life. Keywords: Metabolic syndrome X; Intra-abdominal fat; Computed tomography; Magnetic resonance imaging; Ultrasonography Abbreviations: SM: Metabolic Syndrome; TM: Computer Tomography; RM: Magnetic Resonance Imaging; US: Ultrasonography; BVS: Health Virtual Library; CC: Waist Circumference; IMC: Body Mass Index; GAS: Subcutaneous Abdominal Fat; GAV: Visceral Abdominal Fat
KOMPOSISI DAN STRUKTUR VEGETASI DALAM POTENSINYA SEBAGAI PARAMETER HIDROLOGI DAN EROSI
Authors: Naharuddin Naharuddin
Published: March 2018

The magnitude of the rain interception by the canopy is largely determined by vegetation composition and stratification. The kinetic energy of raindrops changes because the role of the vegetation part inhibits the rate of rainwater. This study aims to determine the composition and structure of vegetation in its potency as a parameter of hydrology and soil erosion. This study used a combination method between the pathway and the way the line is laid out on a sample unit which is a 200 m wide line and 20 m wide lane on each right of the river. In that path, the pots are made continuously. The results showed that vegetation composition in upstream sub region of Miu River Basin was higher than the middle and downstream areas of 19-44 species, 13-22 tribes and individual / ha 112-693 (upstream) respectively. 11-20 species, 8-13 tribes and individuals / ha 83-192 (center), 8-15 species, 6-12 tribes and individuals / ha 60-73 (downstream). The potency of vegetation as a hydrological parameter and soil erosion in Miu Sub-District is very high, which is dominated by Ficus spp. (Moraceae) with stratification of 4 levels, namely B, C, D, and E.Keywords: Composition; vegetation; watershedBesarnya intersepsi hujan oleh tajuk sangat ditentukan oleh komposisi dan stratifikasi vegetasi. Energi kinetik dari tetesan air hujan berubah karena peran bagian-bagian vegetasi yang menghambat laju air hujan. Penelitian ini bertujuan untuk mengetahui komposisi dan struktur vegetasi dalam potensinya sebagai parameter hidrologi dan erosi tanah.Penelitian ini menggunakan metode kombinasi antara cara jalur dan cara garis berpetak pada unit contoh yang berbentuk jalur sepanjang 200 m dan lebar jalur 20 m pada masing-masing kiri kanan sungai, pada jalur tersebut dibuat plot-plot berpetak secara kontinu. Hasil penelitian menunjukan komposisi jenis vegetasi pada wilayah hulu Sub DAS Miu lebih tinggi dibandingkan dengan wilayah tengah dan hilir masing-masing sebesar 19-44 jenis, 13-22 suku dan individu/ha 112-693 (hulu). 11-20 jenis, 8-13 suku dan individu/ha 83-192 (tengah). 8-15 jenis, 6-12 suku dan individu/ha 60-73 (hilir). Potensi vegetasi sebagai parameter hidrologi dan erosi tanah di Sub DAS Miu sangat tinggi yang didominasi jenis Ficus spp. (Moraceae), dengan stratifikasi 4 tingkatan yaitu B, C , D, dan E.Kata Kunci: Komposisi, vegetasi, daerah aliran sungai
Conflicting Roles of Connexin43 in Tumor-Induced Inflammation and Cancer Pathology
Authors: Uzu Miaki , Sin Wun Chey , Shimizu Ayaka , Sato Hiromi
Published: March 2018

The tumor microenvironment is known to have increased levels of cytokines and metabolites, such as glutamate, due to their release from the surrounding cells. A normal cell around the tumor that responds to the inflammatory environment is likely to be subsequently altered. We will discuss how these abnormalities will support tumor survival via the actions of gap junctions (GJs) and hemichannels (HCs) which are composed of hexamer of connexin 43 (Cx43) protein. In particular, we will discuss how GJ intercellular communication (GJIC) in glioma cells, the primary brain tumor, is a regulatory factor and its attenuation leads to tumor invasion. In contrast, the astrocytes, which are normal cells around the glioma, are "hijacked" by tumor cells, either by receiving the transmission of malignant substances from the cancer cells via GJIC, or perhaps via astrocytic HC activity through the paracrine signaling which enable the delivery of these substances to the distal astrocytes. This astrocytic signaling would promote tumor expansion in the brain. In addition, brain metastasis from peripheral tissues has also been known to be facilitated by GJs formed between cerebral vascular endothelial cells and cancer cells. Astrocytes and microglia are generally thought to eliminate cancer cells at the blood brain barrier. In contrast, some reports suggest they facilitate tumor progression as tumor cells take advantage of the normal functions of astrocytes that support the survival of the neurons by exchanging nutrients and metabolites. In summary, GJIC is essential for the normal physiological function of growth and allowing the diffusion of physiological substances. Therefore, whether GJIC is cancer promoting or suppressing may be dependent by what permeates through GJs, when it is active, and to which cells. The nature of GJs, which has been ambiguous in brain tumor progression, will need to be re-visited and understood together with new findings on Cx proteins and HC activities.
A Search for Cardiotropic Biologically Active Substances among New Derivatives of R- phenylimin-1,3-thiazole
Authors: Perekhoda Lina O. , Drapak Irina V. , Suleiman Marharyta M. , Rakhimova Marina V. , Таran Svetlana G. , Yaremenko Vitaliy D. , Gerashchenko Inna V.
Published: March 2018

The purpose of our work was the search for safe and effective biologically active substances of cardiotropic action among 1,3- thiazole derivatives. New derivatives of 1-[(2Z)-2-[R-imin]-4-methyl-3-R1-2,3-dihydro-1,3-thiazole-5-yl]ethan-1-one and ethyl-(2Z)-2-[R-imin]-4-methyl-3-R1-2,3-dihydro-1,3-thiazole-5-carboxylate were synthesized by the Hantzsch reaction. The structure of the compounds obtained was confirmed by 1H NMR spectroscopy and by the elemental analysis. The pharmacological screening showed that the obtained substances possess cardiotropic activity. The cardiotropic properties of the new 1,3-thiazole derivatives were studied on the isolated rings of the thoracic aorta of laboratory rats. A prospective substance 1-[(2Z)-2-[(4-methoxyphenyl)imin]-4-methyl-3-(4-methylpiperazin-1-yl) -2,3-dihydro-1,3-thiazol-5-yl]ethan-1-one hydrochloride, which exhibits cardiotropic activity exceeding the activity of L-carnitine and meldonia has been revealed during pharmacological researches of the substances obtained.
Estimation of Missing Streamflow Data Using Anfis Models and Determination of the Number of Datasets for Anfis: The Case of Yeşilırmak River
Authors: Saplioglu Kemal , Kucukerdem Tulay Sugra
Published: March 2018

Good data analysis is required for the optimal design of water resources projects. However, data are not regularly collected due to material or technical reasons, which results in incomplete-data problems. Available data and data length are of great importance to solve those problems. Various studies have been conducted on missing data treatment. This study used data from the flow observation stations on Yeşilırmak River in Turkey. In the first part of the study, models were generated and compared in order to complete missing data using ANFIS, multiple regression and Normal Ratio Method. In the second part of the study, the minimum number of data required for ANFIS models was determined using the optimum ANFIS model. Of all methods compared in this study, ANFIS models yielded the most accurate results. A 10-year training set was also found to be sufficient as a data set.
Can Periodical Examinations of Employees Be Useful in Detection of Glycaemia Impairment and Improving Patients’ Adherence to Medical Recommendations?
Authors: Marcinkiewicz Andrzej , Hanke Wojciech , Kałużny Paweł , Lipińska-Ojrzanowska Agnieszka , Wiszniewska Marta , Walusiak-Skorupa Jolanta
Published: March 2018

Worldwide epidemiological data indicates insufficient diagnosis of diabetes as an increasing problem of public health. Searching for solutions in this disadvantageous situation, occupational medicine health services seem to open up a unique opportunity to recognize some abnormalities in early steps, especially among the asymptomatic working-age population. 316 workers underwent obligatory prophylactic examinations. In patients with twice assayed FGL ≥ 126 mg/dl (7.0 mmol/l) the additional intervention was implemented, including further diagnostic process and therapy in General Practice (GP), followed by examination by an occupational health specialist within 3 months. The diagnosis of previously unknown diabetes was established among 2.5% of examined workers. All patients referred to the GP due to detected glycaemia impairment visited their doctor and finished the diagnostic process, took up therapy constrained by the occupational health physician to show the effects of intervention within 3 months. Prophylactic medical check-ups allow improved compliance and medical surveillance over glycaemia impairment in patients with prediabetes states, unknown diabetes or uncontrolled clinical course of diabetes. Considering fasting glucose level during mandatory prophylactic examination helps effective prevention of diabetes and its complications and thus give public health system benefits.
Organizational Management Culture and Employers' Health Insurance Offering Strategies in the US: An Ubuntu Based Random Utility Modeling Approach
Authors: Niankara Ibrahim
Published: March 2018

This article takes an approach to explaining the behavioral manifestations of the decision making in US companies’ offer of health insurance that is grounded not only on their cost minimizing behavior, but also in a humanness dimension based on the African concept of Ubuntu. In this way, we define an Ubuntu based Random Utility modeling framework, describing the choice process as a tripartite decision making, and implemented using a nationally representative random sample of 1,061 American companies from the Dunn and Bradstreet Business data, supplied by Survey Sampling International to the Associated Press-NORC Center for Public Affairs Research. The results from the three sequentially implemented specifications showed that the relationship between management culture and health plan offering strategy is dependent on other relevant co-variates, which when left out, leads to the problem of omitted variables bias. However, when all variables are included but assumed to enter the relationship exogenously, this results in management culture not having any statistically significant effect on companies' decisions about scope of health plan offering. When the exogeneity assumption is relaxed through a recursively Bivariate Probit model, the system of two equations produces a highly significant management culture effect. In fact, in this later case we see that companies with groups and formal committee management culture are 1.58 times less likely to choose a multiple plan strategy over a single plan strategy, hence failing to show the more wholesome plan offering that would theoretically prevail under Ubuntu style management.
El video como soporte en la narrativa digital de los eventos turísticos 2.0
Authors:   Universidad de Alicante, Martínez-Sala Alba-María , Campillo Alhama Concepción ,   Universidad de Alicante
Published: March 2018

La presente investigación aborda el reto que plantea la utilización de los eventos 2.0 en la creación y desarrollo de marcas turísticas. Dada la relevancia del formato video en las narrativas digitales resultantes de la comunicación 2.0, nos centramos en el uso e impacto de este formato en la comunicación de los eventos 2.0. La metodología, de carácter descriptivo, consiste en un análisis de contenido cuantitativo de todas las publicaciones relativas a eventos difundidas en los perfiles de Facebook y Twitter de los Sitios Patrimonio Mundial españoles, categoría bienes culturales. Analizamos y evaluamos la difusión de eventos, el formato de dichas publicaciones y la interacción generada a nivel de usuarios, en términos globales y según el formato. Los resultados revelan una incipiente integración de los eventos 2.0 así como un escaso uso del formato video en ambas redes sociales. Por último, los resultados logrados en Facebook confirman la influencia del video en los niveles de interacción, no así los de Twitter. En este sentido concluimos la necesidad de considerar la naturaleza de cada red social, y en consecuencia las distintas expectativas de los usuarios, a la hora de integrarlas en las estrategias de comunicación turísticas.
Juegos, videojuegos y juegos serios: Análisis de los factores que favorecen la diversión del jugador
Authors:   Universitat d'Alacant, Calvo-Ferrer José Ramón
Published: March 2018

A lo largo de la historia, numerosas teorías han tenido como objetivo explicar las razones que subyacen al ejercicio de la actividad lúdica. Con independencia de cualquier marco teórico, parece obvio que se juega a juegos y a videojuegos como consecuencia de que proporcionan diversión al jugador. Distintos autores sugieren que los video juegos son óptimas herramientas educativas, desde la premisa de que atraen al jugador y favorecen el proceso de aprendizaje de diversas maneras. Como consecuencia de ello, educadores y docentes han favorecido el desarrollo e implementación de determinados videojuegos en el ámbito educativo conocidos como videojuegos serios con la esperanza de que faciliten la adquisición de contenidos académicos por parte del alumnado. Sin embargo, los videojuegos tradicionales poseen unas características particulares que, a diferencia de los videojuegos serios, les convierten en herramientas atractivas ante los ojos la mayor parte del público. El presente artículo tiene como objetivo poner de relieve los aspectos que hacen de los videojuegos herramientas divertidas, al tiempo que analiza las diferentes teorías que explican la actividad lúdica y propone una definición de juego y videojuego con el objeto de identificar la peculiar idiosincrasia de los videojuegos serios.
Fusión y fisión familiar. Las mujeres en la reproducción social de la clase media alta argentina contemporánea
Authors: Marentes Maximiliano , Ortega Julián
Published: March 2018

Al hablar de mujeres y reproducción social, el énfasis suele colocarse en actividades domésticas que recaen sobre ellas. Se extiende el concepto para aludir a otro fenómeno menos problematizado: la reproducción social de la clase. En los análisis de la reproducción social, la familia es conceptualizada desde dos vertientes. La primera la toma como una unidad corporativa y los miembros actúan hacia un objetivo común. La segunda, focalizando en las desigualdades de género, observa que los individuos tienen intereses particulares que colisionan entre sí. Con base en los resultados de una investigación sobre mujeres de clase-media alta del área metropolitana de Buenos Aires, se ilustra la pertinencia y complementariedad de los dos enfoques para analizar el papel de ellas con relación a la reproducción social, a partir de sus prácticas cotidianas. Adelantando los resultados, se observó que estas mujeres cuentan con gran participación en las decisiones concernientes a la reproducción social a pesar de persistir el modelo de varón jefe de hogar, reforzado por prácticas domésticas cotidianas. © Universidad Católica Luis Amigó - Revista Colombiana de Ciencias Sociales.
Capital Structure Model (CSM): correction, constraints, and applications
Authors: M. Hull Robert
Published: March 2018

This paper extends the Capital Structure Model (CSM) research by performing the following tasks. First, a correction is offered on the corporate tax rate adjustment found in the break-through concept of the levered equity growth rate (gL) given by Hull (2010). This correction is important because gL links the plowback-payout and debt-equity choices and so its accuracy is paramount. Second, this paper introduces a retained earnings (RE) constraint missing from the CSM growth research when a firm finances with internal equity. The RE constraint governs the plowback-payout and debt-equity choices through the interdependent relation between RE and interest payments (I). Third, a by-product of the RE constraint is a second constraint that governs a no-growth situation so that I does not exceed the available cash flows. Fourth, with the gL correction and two constraints in place, updated applications of prior research and new applications are provided. These applications reveal lower gain to leverage (GL) values than previously reported with more symmetry around the optimal debt-to-equity ratio (ODE) while minimizing steep drop-offs in firm value. For larger plowback ratios, the optimal debt level choice can change. The new constraints serve to point out the need for further research to incorporate external financing within the CSM framework.
Cooperación local binacional: La cuenca internacional del Río Tijuana
Authors: Castro Ruiz José Luis , Mumme Stephen P. , Collins Kimberly
Published: March 2018

Se examina la experiencia de iniciativas de colaboración ambiental a nivel local binacional en la Cuenca del Río Tijuana, y la participación gubernamental de México y Estados Unidos en esos ámbitos. El análisis comprende cuatro puntos principales: las características y problemáticas ambientales de la cuenca; las iniciativas locales binacionales en las últimas décadas; la participación gubernamental en dicha experiencia, en el contexto de las diferencias estructurales entre ambos países, así como algunas reflexiones en el marco del debate global de la importancia de los niveles locales en cuencas transfronterizas. Se ilustra el potencial que iniciativas locales como las estudiadas ofrecen para complementar la búsqueda de soluciones cooperativas a los problemas hídricos comunes entre ambos países. Se concluye que el Acta 320 de la CILA-IBWC constituye una oportunidad única para las instancias gubernamentales mexicanas para instrumentar mecanismos operativos que faciliten la interacción con sus contrapartes sociales y gubernamentales a los niveles sub-nacionales.
A interiorização médica: desafios de um Estado neoliberal / The medical internalization: challenges of a neoliberal State
Authors: Bazarello Raphael Dutra , Silva Frederico Krepe da , Oliveira Camila Maciel de , Mourão Júnior Carlos Alberto
Published: March 2018

Em junho de 2013, o país viveu um momento de efervescência, com diversos protestos ocorrendo nas mais variadas cidades e levando milhões de cidadãos às ruas em um episódio que, sem dúvidas, é o maior evento político no país desde a redemocratização. Dentre as várias pautas – difusas – que foram apresentadas, uma das que mais se destacavam era a da saúde, presente em vários cartazes levados pelos manifestantes ao longo dos protestos. Essa pauta era reflexo dos vários problemas que a saúde no Brasil enfrentava (e enfrenta), e esse tema foi um dos primeiros a ser tratado pelo governo federal ao propor ações na tentativa de responder aos anseios das ruas. Como tentativa de responder a essa questão, o governo propôs o Programa Mais Médicos.Desde o momento em que foi proposto, o programa é alvo de várias discussões públicas, as quais muitas vezes se tornaram acaloradas e entusiasmadas e não permitiram um espaço para um debate sério sobre o Sistema Único de Saúde (SUS) e a Atenção Básica.O presente texto visa, tomando como linha de partida a discussão levantada pelo Mais Médicos, debater a função do Estado enquanto provedor do SUS, bem como suas relações com as demandas por uma saúde pública de qualidade e em consonância com a estrutura e as políticas econômicas governamentais.
The Association Between Increased Levels of Patient Engagement With an Internet Support Group and Improved Mental Health Outcomes at 6-Month Follow-Up: Post-Hoc Analyses From a Randomized Controlled Trial (Preprint)
Authors: Geramita Emily M , Herbeck Belnap Bea , Abebe Kaleab Z , Rothenberger Scott D , Rotondi Armando J , Rollman Bruce L
Published: March 2018

BACKGROUND

We recently reported that depressed and anxious primary care patients randomized to a moderated internet support group (ISG) plus computerized cognitive behavioral therapy (cCBT) did not experience improvements in depression and anxiety over cCBT alone at 6-month follow-up.

OBJECTIVE

The 1% rule posits that 1% of participants in online communities generate approximately 90% of new user-created content. The aims of this study were to apply the 1% rule to categorize patient engagement with the ISG and identify whether any patient subgroups benefitted from ISG use.

METHODS

We categorized the 302 patients randomized to the ISG as: superusers (3/302, 1.0%), top contributors (30/302, 9.9%), contributors (108/302, 35.8%), observers (87/302, 28.8%) and those who never logged in (74/302, 24.5%). We then applied linear mixed models to examine associations between engagement and 6-month changes in health-related quality of life (HRQoL; Short Form Health Survey Mental Health Component, SF-12 MCS) and depression and anxiety symptoms (Patient-Reported Outcomes Measurement Information System, PROMIS).

RESULTS

At baseline, participant mean age was 42.6 years, 81.1% (245/302) were female, and mean Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder scale (GAD-7), and SF-12 MCS scores were 13.4, 12.6, and 31.7, respectively. Of the 75.5% (228/302) who logged in, 61.8 % (141/228) created ≥1 post (median 1, interquartile range, IQR 0-5); superusers created 42.3 % (630/1488) of posts (median 246, IQR 78-306), top contributors created 34.6% (515/1488; median 11, IQR 10-18), and contributors created 23.1 % (343/1488; median 3, IQR 1-5). Compared to participants who never logged in, the combined superuser + top contributor subgroup (n=33) reported 6-month improvements in anxiety (PROMIS: –11.6 vs –7.8; P=.04) and HRQoL (SF-12 MCS: 16.1 vs 10.1; P=.01) but not in depression. No other subgroup reported significant symptom improvements.

CONCLUSIONS

Patient engagement with the ISG was more broadly distributed than predicted by the 1% rule. The 11% of participants with the highest engagement levels reported significant improvements in anxiety and HRQoL.

CLINICALTRIAL

ClinicalTrials.gov NCT01482806; https://clinicaltrials.gov/ct2/show/NCT01482806 (Archived by WebCite at http://www.webcitation.org/708Bjlge9).
The Implementation of an Innovative Hydration Monitoring App in Care Home Settings: A Qualitative Study (Preprint)
Authors: Steven Alison , Wilson Gemma , Young-Murphy Lesley
Published: March 2018

BACKGROUND

In response to marked concern regarding inadequate fluid intake recording in care homes, an innovative mobile hydration app was collaboratively developed. “Hydr8” aimed to facilitate accurate recording and communication of residents’ fluid intake and ultimately increase care quality and patient safety.

OBJECTIVE

The aim of this study was to examine the implementation of Hydr8 in a sample of care homes in one area in England.

METHODS

The principles of Realist Evaluation and Action research were drawn upon throughout the study. Overall, 5 care homes participated in this study, 3 interview-only sites and 2 case-study sites, where interviews and observations were conducted at 3 time-points. Furthermore, 28 staff members participated, including care staff, management, a registered nurse, and administrative staff.

RESULTS

Findings suggest that Hydr8 benefits practice, enhancing the understanding of hydration and person-centered care and improving staff communication. However, technical glitches hindered the seamless embedding of Hydr8 into everyday practice, and enthusiasm for long-term use was dependent on the resolution of issues. In addition, Hydr8 heightened perceptions of personal accountability, and while managers viewed this as positive, some staff members were apprehensive. However, individuals were enthusiastic about the long-term use and potential of Hydr8.

CONCLUSIONS

Utilizing the findings of this study to further develop and adapt Hydr8 indicates the long-term use of Hydr8 as promising. Although perceptions of Hydr8 were primarily positive, setbacks in its implementation and use created difficulties in normalizing the solution into everyday practice. This study highlights the need for education related to hydration practice and a change of infrastructure in care home settings to implement technical solutions and changes to care.
On the equivalence between Perov fixed point theorem and Banach contraction principle
Authors: Cvetkovic Marija
Published: March 2018

There are many results in the fixed point theory that were presented as
generalizations of Banach theorem and other well-known fixed point theorems,
but later proved equivalent to these results. In this article we prove that
Perov?s existence result follows from Banach theorem by using renormization
of normal cone and obtained metric. The observed estimations of approximate
point given by Perov, could not be obtained from consequences of Banach
theorem on metric spaces.
Ciric type nonunique fixed point theorems on b-metric spaces
Authors: Alsulami Hamed , Karapınar Erdal , Rakocevic Vladimir
Published: March 2018

In this paper, inspired the very interesting results of Ciric [20], we
investigate the existing non-unique fixed points of certain operators in the
context of b-metric spaces. Our main results unify and cover several
existing results on the topic in the literature.
Fixed point theorems for two pairs of mappings satisfying a new type of common limit range property
Authors: Popa Valeriu
Published: March 2018

The purpose of this paper is to prove a general fixed point theorem for
mappings involving almost altering distances and satisfying a new type of
common limit range property which generalize the results from Theorem 2.9
[19]. In the last part of the paper, as applications, some fixed point
results for mappings satisfying contractive conditions of integral type for
almost contractive mappings for ?-contractive mappings and (?,?) - weak
contractive mappings in metric spaces are obtained.
A generalization of Reich’s fixed point theorem for multi-valued mappings
Authors: Nastasi Antonella , Vetro Pasquale
Published: March 2018

Motivated by a problem concerning multi-valued mappings posed by Reich [S.
Reich, Some fixed point problems, Atti Accad. Naz. Lincei Rend. Cl. Sci.
Fis. Mat. Natur. 57 (1974) 194-198] and a paper of Jleli and Samet [M.
Jleli, B. Samet, A new generalization of the Banach contraction principle,
J. Inequal. Appl. 2014:38 (2014) 1-8], we consider a new class of
multi-valued mappings that satisfy a ?-contractive condition in complete
metric spaces and prove some fixed point theorems. These results generalize
Reich?s and Mizoguchi-Takahashi?s fixed point theorems. Some examples are
given to show the usability of the obtained results.
Applications of measures of noncompactness to infinite system of fractional differential equations
Authors: Mursaleen Mohammad , Bilalov Bilal , Rizvi Syed
Published: March 2018

In this paper, we discuss few existence result for solution of an infinite
system of fractional differential equations of order ?(1 < ? < 2), with three
point boundary value problem in the interval [0, T]. The problem is studied
in the classical Banach sequence spaces c0 and lp (1 ? p < 1), using
Hausdorff measure of noncompactness and Darbo type fixed point theorem. We
also illustrate our results through some concrete examples.
On the local uniqueness of the fixed point of the probabilistic q-contraction in fuzzy metric spaces
Authors: Hadzic Olga , Pap Endre
Published: March 2018

In this paper we prove the local uniqueness of the fixed point of the
probabilistic q-contraction in fuzzy metric space.
Fixed points and continuity of contractive maps
Authors: Pant Abhijit , Pant R.P.
Published: March 2018

The aim of this paper is to generalize celebrated results due to Boyd and
Wong [2] and Matkowski [9] and also to provide yet new solutions to the once
open problem on the existence of a contractive mapping which possesses a
fixed point but is not continuous at the fixed point. Besides continuous
mappings our results also apply to discontinuous mappings which include
threshold operations that are integral part of many a phenomena.
Impact of Body Weight Loss From Maximum Weight on Fragility Bone Fractures in Japanese Patients With Type 2 Diabetes: The Fukuoka Diabetes Registry
Authors: Komorita Yuji , Iwase Masanori , Fujii Hiroki , Ohkuma Toshiaki , Ide Hitoshi , Jodai-Kitamura Tamaki , Sumi Akiko , Yoshinari Masahito , Nakamura Udai , Kang Dongchon , Kitazono Takanari
Published: March 2018

OBJECTIVE

There is growing evidence that weight loss is associated with increased fracture risk in the general population. As patients with diabetes often lose weight intentionally or unintentionally, we aimed to investigate prospectively the relationship between weight loss from maximum body weight and fracture risk.

RESEARCH DESIGN AND METHODS

A total of 4,706 Japanese participants with type 2 diabetes (mean age 66 years), including 2,755 men and 1,951 postmenopausal women, were followed for a median of 5.3 years and were divided according to weight loss from maximum weight: <10%, 10% to <20%, 20% to <30%, and ≥30%. The primary outcomes were fragility fractures defined as fractures at sites of hip and spine.

RESULTS

During the follow-up period, fragility fractures occurred in 198 participants. The age- and sex-adjusted incidence rates per 1,000 person-years in all participants were 6.4 (<10% weight loss from maximum body weight), 7.8 (10% to <20%), 11.7 (20% to <30%), and 19.2 (≥30%) (P for trend <0.001). Multivariate-adjusted hazard ratios for fragility fractures compared with reference (<10% weight loss) were 1.48 (95% CI 0.79–2.77) in the 10% to <20% group, 2.23 (1.08–4.64) in 20% to <30%, and 5.20 (2.15–12.57) in ≥30% in men, and 1.19 (0.78–1.82) in 10% to <20%, 1.62 (0.96–2.73) in 20% to <30%, and 1.97 (0.84–4.62) in ≥30% in postmenopausal women.

CONCLUSIONS

The current study demonstrates that ≥20% body weight loss from maximum weight is a significant risk factor for fragility fractures in patients with type 2 diabetes, especially in men.
Correlations Between A1C and Diabetes Knowledge, Diabetes Numeracy, and Food Security in a Vulnerable Type 2 Diabetes Population
Authors: Young Clipper F. , Yun Kenneth , Kang Edward , Shubrook Jay H. , Dugan Joy A.
Published: March 2018

Type 2 diabetes is over-represented in vulnerable populations. Vulnerable patients managing diabetes are challenged with less-than-optimal processes and outcomes of care; thus, Healthy People 2020 and the American Diabetes Association have renewed the focus on social determinants of health with regard to the management of chronic diseases such as diabetes. This study explored the correlations between A1C and social and personal factors, including diabetes knowledge, diabetes numeracy, and food security. The Diabetes Numeracy Test-15, the Spoken Knowledge in Low Literacy Diabetes Scale, and the U.S. Department of Agriculture Food Security Questionnaire were administered to a Caucasian study population (n = 96) receiving diabetes care at a federally qualified health center. Although the correlation coefficients generated by the results obtained from the three questionnaires and A1C levels were generally small, a correlation coefficient of 0.46 was found between food security and A1C. An improved understanding of factors that contribute to the successful self-management of diabetes is necessary to improve diabetes outcomes in vulnerable populations.
PERCEPATAN PERTUMBUHAN PERBANKAN SYARIAH MELALUI IMPLEMENTASI TATA KELOLA SYARIAH
Authors: Abubakar Lastuti , Handayani Tri
Published: March 2018

Pertumbuhan industri perbankan syariah  Indonesia menunjukkan grafik meningkat, walaupun mengalami perlambatan. Data yang dipublikasi oleh OJK menunjukkan bahwa perbankan syariah nasional  berkontribusi sebesar 4.81 % terhadap market share dengan pertumbuhan  assets mencapat 11.97 % per Juni 2016. Di tataran global, sektor jasa keuangan syariah termasuk perbankan, menguasai 3 % dan  bersama sama dengan Qatar, Arab Saudi, Malaysia, Uni Emirat Arab dan Turki menjadi kekuatan pendorong keuangan syariah di masa depan. Salah satu isu startegis yang menjadi hambatan adalah mispersepsi masyarakat terhadap perbankan syariah baik mengenai akad, produk dan layanan yang belum patuh terhadap prinsip syariah. Implementasi tatakelola merupakan upaya untuk mempercepat pertumbuhan perbankan syariah.Keywords : Perbankan syariah- tata kelola- percepatan pertumbuhan.
KINERJA GURU BERSERTIFIKASI DALAM MENINGKATKAN MANAJEMEN MUTU PENDIDIKAN DI MADRASAH IBTIDAIYAH MUHAMMADIYAH SUDUNG KEDUNGTUBAN BLORA TAHUN 2015
Authors: Shobron Sudarno , Suyanto Suyanto
Published: March 2018

The performance of school teachers be one of the important factors in improving theschools quality. Certified teachers in Ibtidaiyah Elementary School of Muhammadiyah SudungBlora include planning and implementation of education quality development has been carriedout effectively and efficiently. It is characterized by the realization of the development of theimplementation of learning and learning outcomes in accordance with the vision and missionof the madrassa. support Factor in improving education quality management are 1) Availabilityof adequate learning media and support ongoing learning activities; 2) The interest andenthusiasm of students is increasing in participating in learning activities; 3) Preparation ofteachers in teaching is increasing; 4) The climate in the classroom learning environment moreconducive; 5) There is full support of the school community, society, and government; 6) Suppliedfacilities for picking up the students to and from school by teachers. Inhibiting factors inimproving the quality of education management in MI Muhammadiyah Sudung are 1) Lackof facilities to support the library and its contents; 2) Many teachers who are still miss match(not in accordance with the latest science education qualifications); 3) Lack of infrastructureeg. UKS room, and laboratory, so it is still a hard time in learning practices.Keywords: teacher performance; certification; management quality; education.Abstrak: Kinerja guru disekolah menjadi salah satu faktor penting dalam meningkatkanmutu sekolah. Guru bersertifikasi di Madrasah Ibtidaiyah Muhammadiyah Sudung KabupatenBlora meliputi perencanaan dan pelaksanaan pengembangan mutu pendidikan telahdilakukan secara efektif dan efisien. Hal ini ditandai dengan terwujudnya pengembanganpelaksanaan pembelajaran dan hasil pembelajaran sesuai dengan visi dan misi madrasah. Fakorpendukung dalam meningkatkan manajemen mutu pendidikan ialah 1) Tersedianya mediapembelajaran yang memadai dan menunjang berlangsungnya kegiatan belajar mengajar; 2)Minat dan semangat siswa semakin meningkat dalam mengikuti kegiatan pembelajaran; 3)Persiapan guru dalam pembelajaran semakin meningkat; 4) Iklim lingkungan belajar dalamkelas yang semakin kondusif; 5) Adanya dukungan penuh dengan warga sekolah, masyarakat,dan pemerintah; 6) Disediakan fasilitas antar jemput siswa saat berangkat dan pulang sekolaholeh guru-guru. Faktor penghambat dalam meningkatkan manajemen mutu pendidikan di MIMuhammadiyah Sudung ialah 1) Kurangnya fasilitas pendukung perpustakaan beserta isinya;2) Tenaga pengajar masih banyak yang miss match (tidak sesuai dengan kualifikasi ilmupendidikan terakhir); 3) Kurangnya sarana prasarana misalnya ruangan UKS, dan laboratorium, sehingga masih kesulitan saat praktek pembelajaran.Kata Kunci: kinerja guru; sertifikasi; manajemen mutu; pendidikan.