bluuebunny/crossref_metadata_2025 huggingface dataset:
Poor nutrition doubles post-COVID-19 syndrome risk in cancer patients: insights from a Chinese multicentre study
Authors: Zhang Liangyuan , Yu Haihang , Yang Jianzhou , Su Rila , Zhang Jiaqi , Zeng Rongbiao , Liu Yajie , Zhang Lei , Xu Junjie
Published: October 2024

Background

Since 2019, approximately 760 million SARS-CoV-2 cases have been reported globally, with post-COVID-19 syndrome posing significant challenges for cancer patients due to their immunosuppressed status and poor nutritional conditions. The role of nutritional status in influencing their infection risk and post-COVID-19 outcomes remains unclear, underscoring the need for targeted research and strategies.

Objective

To investigate the impact of baseline nutritional status on SARS-CoV-2 infection and the risk of post-COVID-19 syndrome in cancer patients.

Methods

A multicenter cross-sectional study was conducted from December 2022 to June 2023 in four tertiary hospitals across China. Cancer inpatients aged 18 years and older were enrolled and classified into two groups based on their Nutritional Risk Screening (NRS) scores. The correlation between SARS-CoV-2 infection, post-COVID-19 syndrome and nutritional status were analyzed using multivariable logistic regression.

Results

Among 834 eligible cancer patients, 10.8% were in the high nutritional risk group (NRS ≥ 3). The prevalence of SARS-CoV-2 infection was 58.8% (95% confidence interval, CI: 56.8–60.8%), and post-COVID-19 syndrome was 21.0% (95% CI: 10.4–14.4%). After adjusting for confounding factors, the high nutritional risk group had a significantly higher prevalence of post-COVID-19 syndrome compared to the low nutritional risk group (32.7% vs. 19.5%, AOR: 2.37, 95% CI: 1.23–4.54, p = 0.010). However, no significant difference in SARS-CoV-2 infection rates was found between the two groups (61.1% vs. 58.5%, AOR: 1.12, 95% CI: 0.70–1.80; p = 0.634).

Interpretation

Poor baseline nutritional status in cancer patients is associated with a higher prevalence of post-COVID-19 syndrome, providing preliminary information on post-COVID-19 syndrome in this population. These findings underscore the importance of adequate nutritional management in cancer patients, particularly during pandemic recurrences.
Application of preoperative NLR-based prognostic model in predicting prognosis of intrahepatic cholangiocarcinoma following radical surgery
Authors: Qi Shuo , Ma Zhongzhi , Shen Lian , Wang Jun , Zhou Lei , Tian Bingzhang , Liu Changjun , Chen Kang , Cheng Wei
Published: October 2024

Purpose

To investigate the application value of the neutrophil to lymphocyte count ratio (NLR) in the prognostic analysis of intrahepatic cholangiocarcinoma (ICC) after radical resection, and to offer guidance for the individualized perioperative diagnosis and treatment of ICC.

Methods

The clinical data of 360 patients diagnosed with ICC following radical surgery were retrospectively analyzed. The cut-off value of NLR was calculated using the minimum p-value method, and then divided into High-NLR (H-NLR) group and Low-NLR (L-NLR) group according to the NLR cut-off value. The prognostic value of NLR in ICC was analyzed. Subsequently, the patients were divided into the hepatolithiasis-related intrahepatic cholangiocarcinoma (HICC) group and the non-hepatolithiasis-related intrahepatic cholangiocarcinoma (NHICC) group based on whether they combined with hepatolithiasis. Multiple regression models were constructed based on NLR and clinicopathological indicators to verify the application value of prognostic models in the survival and recurrence of ICC patients after radical surgery.

Results

The cut-off value of NLR was 2.36, and the survival analysis disclosed that overall ICC patients with NLR ≥ 2.36 manifested a poor 5-year survival rate and a higher tumor recurrence rate (p < 0.001). In the HICC group, patients with H-NLR presented a poor 5-year survival rate and a higher tumor recurrence rate compared with L-NLR (p < 0.001). The NLR-based survival/recurrence prediction models in the HICC group demonstrated excellent predictive capacity (H-L test: 0.359/0.680, AUC: 0.764/0.791). In the NHICC group, patients with H-NLR exhibited a poor 5-year survival rate compared with L-NLR (p < 0.001), yet there was no significant difference in tumor recurrence between the two groups (p = 0.071). The NLR-based survival prediction model in the NHICC group demonstrated acceptable predictive ability (H-L test: 0.268, AUC: 0.729), while the NLR-based recurrence prediction model did not show an effective predictive ability (H-L test: 0.01, AUC: 0.649).

Conclusion

NLR is an independent risk factor influencing postoperative survival and recurrence in ICC patients, particularly in HICC patients. Preoperative NLR ≥ 2.36 suggests that patients might have a poor prognosis. The survival and recurrence prediction model constructed based on NLR and other clinical indicators demonstrates good prediction accuracy and can effectively predict the risk of postoperative adverse prognosis in patients with HICC. This study offers a novel idea for the clinical treatment of HICC patients.
Comparing ischemic cardiovascular effectiveness and safety between individual SGLT-2 inhibitors and DPP-4 inhibitors in patients with type 2 diabetes: a nationwide population-based cohort study
Authors: Kim Hayeon , Seo Jun-Ho , Nam Jin Hyun , Lim Yejee , Choi Kyung Hee , Kim Kyungim
Published: October 2024

Objectives

This study compared the ischemic cardiovascular events (iCVEs) effectiveness and safety of initiating empagliflozin or dapagliflozin with those of dipeptidyl peptidase-4 inhibitors (DPP-4is), as well as the comparative effects between empagliflozin and dapagliflozin.

Methods

Using data from the National Health Insurance Service in Korea, patients with type 2 diabetes mellitus (T2DM) who were newly prescribed empagliflozin, dapagliflozin, or DPP-4is from 2016 to 2019 and who did not have a recent CVE history were included. A Cox proportional hazards regression model was used to estimate the adjusted hazard ratio (aHR) with 95% confidence intervals (CIs) for iCVEs and safety events.

Results

Empagliflozin and dapagliflozin significantly reduced the risks of ischemic stroke (aHR 0.568, 95% CI 0.408–0.791; aHR 0.612, 95% CI 0.476–0.786, respectively) and all-cause mortality (aHR 0.590, 95% CI 0.442–0.788; aHR 0.730, 95% CI 0.603–0.884, respectively) compared with DPP-4is. Initiating dapagliflozin or empagliflozin was associated with significantly lower incidence of severe hypoglycemia, bone fracture, urinary tract infection, and acute kidney injury than that of DPP-4is. No significant differences were observed between empagliflozin and dapagliflozin in iCVEs and most safety outcomes.

Conclusion

Empagliflozin and dapagliflozin showed significant preventive effects on ischemic stroke and all-cause mortality compared with DPP-4is in patients with T2DM, and their protective effects were similar. Both empagliflozin and dapagliflozin were not related to the harmful effects on most safety events. These results suggest that it may be beneficial to initiate empagliflozin or dapagliflozin for ischemic stroke prevention in patients with T2DM. However, further validation studies, such as randomized controlled trials, are needed to generalize these results.
Harnessing MEMS sensors and statistics to unravel rock fracture
Authors: Pan Xuezai , Dai Guoxing
Published: October 2024

This study focuses on obtaining differences in rock fracture surface morphology under various loading directions and speeds to infer rock damage mechanics by using micro-electro–mechanical system (MEMS) sensors, which can measure stress, strain, and displacement during loading accurately, providing detailed data for understanding the rock fracture mechanism for physics-informed statistics. Statistical variables analyze directional angle samples of the normal vector central line. The deviation normal distribution coefficient (DNDC) for rock fracture surface normal vectors is defined by the kurtosis coefficient. Brazilian splitting tests calculate the DNDC for Brazilian disk fracture surfaces. The variation in the DNDC with a measurement scale distinguishes morphological differences. Three results are obtained: the DNDC has a scale effect; loading the specimen in another direction before compression causes internal damage; and different loading speeds do not significantly change the DNDC. This research holds promise for a better understanding of rock fractures.
CardioMEA: comprehensive data analysis platform for studying cardiac diseases and drug responses
Authors: Lee Jihyun , Duperrex Eliane , El-Battrawy Ibrahim , Hohn Alyssa , Saguner Ardan M. , Duru Firat , Emmenegger Vishalini , Cyganek Lukas , Hierlemann Andreas , Ulusan Hasan
Published: October 2024

Introduction

In recent years, high-density microelectrode arrays (HD-MEAs) have emerged as a valuable tool in preclinical research for characterizing the electrophysiology of human induced pluripotent stem-cell-derived cardiomyocytes (iPSC-CMs). HD-MEAs enable the capturing of both extracellular and intracellular signals on a large scale, while minimizing potential damage to the cell. However, despite technological advancements of HD-MEAs, there is a lack of effective data-analysis platforms that are capable of processing and analyzing the data, particularly in the context of cardiac arrhythmias and drug testing.

Methods

To address this need, we introduce CardioMEA, a comprehensive data-analysis platform designed specifically for HD-MEA data that have been obtained from iPSCCMs. CardioMEA features scalable data processing pipelines and an interactive web-based dashboard for advanced visualization and analysis. In addition to its core functionalities, CardioMEA incorporates modules designed to discern crucial electrophysiological features between diseased and healthy iPSC-CMs. Notably, CardioMEA has the unique capability to analyze both extracellular and intracellular signals, thereby facilitating customized analyses for specific research tasks.

Results and discussion

We demonstrate the practical application of CardioMEA by analyzing electrophysiological signals from iPSC-CM cultures exposed to seven antiarrhythmic drugs. CardioMEA holds great potential as an intuitive, userfriendly platform for studying cardiac diseases and assessing drug effects.
Comparative proteomic analysis provides insights into wood formation in immature xylem at different ages in Eucalyptus urophylla × Eucalyptus grandis
Authors: Liu Guo , Zhang Guowu , Wu Zhihua , Lu Wanhong , Lin Yan , Wang Chubiao , Shang Xiuhua , Huang Anying , Luo Jianzhong
Published: October 2024

Introduction

Wood formation is a crucial developmental stage in the life cycle of a woody plant; this process has substantial scientific research implications and practical applications. However, the mechanisms underlying woody plant development, especially the process of wood formation, remain poorly understood. As eucalyptus is one of the fastest growing tree species in the world, understanding the mechanism of wood formation in eucalyptus will greatly promote the development of molecular breeding technology for forest trees.

Results

In this study, we investigated the proteomic profile of immature xylem at four different ages of Eucalyptus urophylla × Eucalyptus grandis (E. urograndis) using iTARQ technology. We identified 5236 proteins and 492 differentially abundant proteins (DAPs). The expression profiles of the DAPs corresponding to coding genes associated with wood formation were assessed using qRT-PCR. From the different expression profiles, it is inferred that the genes encoding kinesin, CDKD3, EXPA13, EXPA2, XTH27, EGases, UGT76E2, LAC, CCoAMT, CesA3, PAL, and CAD may undergo posttranscriptional regulation (PTR). Additionally, the genes encoding EIN2, ETR, MC4-like, and XCP may undergo posttranslational modifications (PTMs).

Conclusions

We investigated changes in wood formation-related proteins at the protein abundance level in the immature xylem of E. urograndis, thereby elucidating potential regulatory mechanisms of key proteins involved in eucalyptus wood formation. This study may provide theoretical guidance for further research on molecular breeding techniques and genetic improvement related to the cultivation of rapidly growing and high-quality trees.
An improved YOLOv8n-IRP model for natural rubber tree tapping surface detection and tapping key point positioning
Authors: Zhang Xirui , Ma Weiqiang , Liu Junxiao , Xu Ruiwu , Chen Xuanli , Liu Yongqi , Zhang Zhifu
Published: October 2024

Aiming at the problem that lightweight algorithm models are difficult to accurately detect and locate tapping surfaces and tapping key points in complex rubber forest environments, this paper proposes an improved YOLOv8n-IRP model based on the YOLOv8n-Pose. First, the receptive field attention mechanism is introduced into the backbone network to enhance the feature extraction ability of the tapping surface. Secondly, the AFPN structure is used to reduce the loss and degradation of the low-level and high-level feature information. Finally, this paper designs a dual-branch key point detection head to improve the screening ability of key point features in the tapping surface. In the detection performance comparison experiment, the YOLOv8n-IRP improves the D_mAP50 and P_mAP50 by 1.4% and 2.3%, respectively, over the original model while achieving an average detection success rate of 87% in the variable illumination test, which demonstrates enhanced robustness. In the positioning performance comparison experiment, the YOLOv8n-IRP achieves an overall better localization performance than YOLOv8n-Pose and YOLOv5n-Pose, realizing an average Euclidean distance error of less than 40 pixels. In summary, YOLOv8n-IRP shows excellent detection and positioning performance, which not only provides a new method for the key point localization of the rubber-tapping robot but also provides technical support for the unmanned rubber-tapping operation of the intelligent rubber-tapping robot.
Synergistic effects of SAP and PGPR on physiological characteristics of leaves and soil enzyme activities in the rhizosphere of poplar seedlings under drought stress
Authors: Jing Dawei , Liu Fangchun , Li Shanwen , Dong Yufeng
Published: October 2024

Super absorbent polymers (SAP) provide moisture conditions that allow plant growth-promoting rhizobacteria (PGPR) to enter the soil for acclimatization and strain propagation. However, the effects of SAP co-applied with PGPR on the physiological characteristics of leaves and rhizosphere soil enzyme activities of poplar seedlings are not well understood. Here, a pot experiment using one-year-old poplar seedlings with five treatments, normal watering, drought stress (DR), drought stress + SAP (DR+SAP), drought stress + Priestia megaterium (DR +PGPR) and drought stress + SAP + P. megaterium (DR+S+P), was performed to analyze the contents of non-enzymatic antioxidants, osmotic regulators and hormones in leaves, as well as rhizosphere soil enzyme activities. Compared with normal watering, the DR treatment significantly decreased the contents of dehydroascorbate (DHA; 19.08%), reduced glutathione (GSH; 14.18%), oxidized glutathione, soluble protein (26.84%), indoleacetic acid (IAA; 9.47%), gibberellin (GA) and zeatin (ZT), the IAA/abscisic acid (ABA), GA/ABA, ZT/ABA and (IAA+GA+ZT)/ABA (34.67%) ratios in leaves, and the urease and sucrase activities in the rhizosphere soil. Additionally, it significantly increased the soluble sugar, proline and ABA contents in leaves. However, in comparison with the DR treatment, the DR+S+P treatment significantly increased the DHA (29.63%), GSH (15.13%), oxidized glutathione, soluble protein (29.15%), IAA (12.55%) and GA contents, the IAA/ABA, GA/ABA, ZT/ABA and (IAA+GA+ZT)/ABA (46.85%) ratios in leaves, and the urease, sucrose and catalase activities in rhizosphere soil to different degrees. The soluble sugar, proline and ABA contents markedly reduced in comparison to the DR treatment. The effects of the DR+SAP and DR+PGPR treatments were generally weaker than those of the DR+S+P treatment. Thus, under drought-stress conditions, the simultaneous addition of SAP and P. megaterium enhanced the drought adaptive capacities of poplar seedlings by regulating the non-enzymatic antioxidants, osmotic regulators, and endogenous hormone content and balance in poplar seedling leaves, as well as by improving the rhizosphere soil enzyme activities.
The relationship between teacher–student relationships and academic grades among Chinese rural high school students: the moderating role of mental health symptoms and the conditional moderating effect of academic resilience
Authors: Chen Xiaohui , Bailey Richard Peter , Yin Xiaojiao , Samsudin Nadia
Published: October 2024

Objective

This study examines the relationship between Teacher–Student Relationships and academic grades among Chinese rural high school students, focusing on the moderating role of mental health symptoms and the conditional moderating effect of academic resilience.

Method

A moderated moderation analysis was conducted via Mplus on data collected from a sample of rural Chinese high school students. SEM was used to test the direct and interactive effects of these variables on academic outcomes.

Results

Teacher–Student Relationships were found to have a significant positive association with students’ academic grades. Academic resilience plays a conditional moderating role, with students who have higher levels of resilience better able to maintain their academic performance, even when facing psychological distress. This suggests that resilience can buffer the impact of challenges, enhancing the positive influence of TSRs on academic outcomes.
A narrative exploration of psilocybin’s potential in mental health
Authors: Min Huitae , Park Soon Young , Park Jisu , Na Seongsu , Lee Hoe-Suk , Kim Taejung , Ham Jungyeob , Park Young-Tae
Published: October 2024

Psilocybin, a psychoactive substance, has recently garnered attention for its high therapeutic potential in psychiatry. In this study, we investigated the multifaceted aspects of psilocybin, highlighting its chemical properties, mechanisms of action, and burgeoning role in psychiatric treatment. Furthermore, we examined the clinical applications and potential therapeutic benefits of psilocybin in the treatment of various mental health disorders, supported by accumulating clinical evidence. This review aims to deepen our understanding of the clinical impact of psilocybin, elucidate its therapeutic value, and propose directions for future research, thereby paving the way for its integration into mainstream psychiatric treatments. Psilocybin has been shown to be safe in clinical trials with manageable side effects. However, additional safety measures are required after this discussion, including dosing protocols, patient monitoring, and distress management strategies.
The clock is ticking on schizophrenia: a study protocol for a translational study integrating phenotypic, genomic, microbiome and biomolecular data to overcome disability
Authors: Mercuriali Giacomo , Lodde Lorenzo , Paribello Pasquale , Sapienza Jacopo , Corona Alice , Ave Chiara , Pacini Delia , Nocera Daniela , Corrias Carolina , El Kacemi Sabrina , D'Incalci Michele , Frau Ilaria , Monzani Elena , Valtorta Flavia , Congiu Donatella , Meloni Anna , Scherma Maria , Fadda Paola , Dedoni Simona , Siddi Carlotta , Sut Stefania , Dall’Acqua Stefano , Nasini Sofia , Barzon Benedetta , Squassina Alessio , Cavallaro Roberto , Manchia Mirko , Pisanu Claudia , Bosia Marta , Comai Stefano
Published: October 2024

Background

Shared biological factors may play a role in both the cognitive deficits and the increased prevalence of metabolic syndrome observed in individuals with Schizophrenia (SCZ). These factors could entail disturbances in tryptophan (Trp) to both melatonin (MLT) and kynurenine (Kyn) metabolic pathways, as well as inflammation and alterations in the gut microbiome composition.

Methods

The present research project aims to investigate this hypothesis by recruiting 170 SCZ patients from two different recruitment sites, assessing their cognitive functions and screening for the presence of metabolic syndrome. Additionally, we plan to assess the impact of a 3-month cognitive remediation therapy on 30 of these patients. We will analyze clinical data alongside serum biomarkers and gene expression related to the Trp- to MLT and Kyn metabolic pathways, markers of inflammatory and composition of the gut microbiome. The association between Trp-MLT-Kyn levels, expression levels of selected genes, inflammatory markers and clinical phenotypes will be analyses in the context of general linear models.

Discussion

This project has the potential to identify some typical SCZ symptomatic clusters that will be more stringently associated with variations in the Trp-MLT-Kyn/inflammatory system and with a better response to cognitive remediation therapy. Moreover, in a future perspective, it may highlight a group of patients who may benefit from a pharmacological treatment aiming at reinstating the physiological Trp to MLT and Kyn system. Therefore, it has the potential to move research toward a personalized approach for SCZ management.
Effect of cognitive remediation therapy in anorexia nervosa: a systematic review and meta-analysis
Authors: Alserihi Anas R. , Hubayni Wejdan A. , Alotaibi Solaf Hilal , Bahkali Sadeem , Alqurashi Shatha , Abualola Muhannad Sadakah , Alsaleh Ahmad Mohammed
Published: October 2024

Background

Anorexia nervosa (AN) can significantly affect cognitive well-being. Cognitive remediation therapy (CRT) is regarded as one of the effective treatments for cognitive impairment in some mental illnesses such as schizophrenia, bipolar disorder, and attention deficit. For this reason, this systematic review and meta-analysis aim to assess the effectiveness of CRT in patients with AN.

Methods

We conducted a search of Medline, ClinicalTrials.gov, and the Cochrane Database of Systematic Reviews from the inception of each database through April 8, 2023. Randomized clinical trials evaluating the effectiveness of CRT in comparison to placebo or other psychological treatments in patients with AN were included. The quality of the studies was assessed using the revised Cochrane risk-of-bias tool. For meta-analysis, effect sizes were measured using mean difference (MD) utilizing the random-effects model and inverse variance (IV) technique. To evaluate the certainty of the evidence, we applied the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria. The study was registered in PROSPERO, ID: CRD42023411784.

Results

In the systematic review, six studies were included, of which four underwent meta-analysis. Among these, three trials encompassing 413 participants showed that CRT was associated with improved cognitive flexibility compared to control at the end of treatment (MD = -0.21, 95% CI [-0.44, 0.02], P=0.81, I2 = 0%). In two trials with 143 patients, those who received CRT showed similar effects on the severity of AN symptoms compared to the control group in the self-reporting questionnaires: EDE-Q (MD = -0.25, 95% CI [-0.76, 0.27], P=0.77, I2 = 0%) and EDEQOL (MD = -0.19, 95% CI [-0.41, 0.03], P=0.84, I2 = 0%).

Conclusion

CRT did not show a statistically significant difference compared to the control group in improving abstract thinking skills and quality of life in individuals with AN. That indicates that CRT’s efficacy remains inconclusive. Further research with larger, more diverse samples is needed to determine its long-term effects and potential benefits.

Systematic review registration

PROSPERO, identifier CRD42023411784.
A mindfulness-based intervention for Substance Use Disorder in a Brazilian vulnerable population: a feasibility mixed method study
Authors: Machado Mayra Pires Alves , Opaleye Emérita Sátiro , Bedendo Andre , Bowen Sarah , Noto Ana Regina
Published: October 2024

Introduction

Substance Use Disorder (SUD) is a chronic condition that impacts various facets of an individual’s life, and society as a whole. The Mindfulness-Based Relapse Prevention (MBRP) protocol is an innovative intervention that can help to prevent relapse, particularly when used as a post-treatment approach. However, although there is significant evidence of its effectiveness in studies from high-income countries (HICs), there is a dearth of studies examining its feasibility and efficacy in low- and middle-income countries (LMICs). Thus, this study investigates the feasibility of MBRP as an adjunct to outpatient treatment for SUD in a socially vulnerable Brazilian population.

Methods

The study employed a mixed-methods design in eight Psychosocial Care Centers for Alcohol and Drugs (CAPS-ad) in the city of São Paulo, and involved 140 participants, 24 healthcare professionals and 7 CAPS-ad managers. In total, 17 MBRP intervention groups were conducted. The study assessed qualitative indicators of acceptability, demand, implementation, adaptation, integration, and limited efficacy testing through group interviews, in-depth interviews and field diary records. It also included limited efficacy testing of the protocol using a quantitative pre-post pilot study to investigate consumption behavior, using the Timeline Followback (TLFB) assessment method; depression, using the Center for Epidemiologic Studies Depression (CES-D) scale; anxiety, using the state trait anxiety index (STAXI-2); craving, using the Penn Alcohol Craving Scale (PACS); readiness to change, using the Readiness-to-Change Ruler (RCR); and severity of dependence, using the Severity of Dependence Scale (SDS). The qualitative data were triangulated with the quantitative data to comprehensively evaluate the feasibility of the intervention.

Results

The sample comprised socially vulnerable participants with a high dropout rate, primarily due to social factors. Despite facing challenges in respect of regular engagement and initial cultural misperceptions of meditation, the intervention showed positive acceptance and mental health benefits, including impacts on consumption behavior.

Discussion

The study emphasizes the importance of adapting the format of the protocol to better suit vulnerable populations, and to ensure its effective integration into the public healthcare system. Future research should explore protocol modifications, assess its effectiveness in different contexts, and conduct cost-benefit analyses for broader implementation.
Frailty and suicidal ideation among older adults living alone in the community: a moderated mediation model of perceived burdensomeness and positive emotions
Authors: Yang Yang , Zhang Xinyue , Zhang Dan , Su Yonggang
Published: October 2024

Background

Suicide rates among older adults individuals living alone in the community are comparatively high. The prevalence of suicidal ideation among older adults living alone in the community was assessed using the interpersonal-psychological theory of suicide and the broaden-and-build theory of positive affect.

Objectives

The research objectives of this study was examine to the prevalence of suicidal ideation among older adults living alone in the community. It was examined whether perceived burdensomeness mediated the relation between frailty and suicidal ideation, and whether positive emotions moderated either the indirect or direct effect of a mediation model.

Methods

The model was tested on 893 older adults people living alone in the community in Xintai City, China. An assessment of participants’ frailty, suicidal ideation, perceived burdensomeness, and positive emotions was conducted.

Results

The results demonstrated that perceived burdensomeness acted as a partly mediating factor in the relationship between frailty and suicidal ideation. In addition, the direct and indirect effects of the mediation model were moderated by positive emotions. When levels of positive emotion were high, fragility had a weaker effect on suicidal ideation, and perceived burdensomeness had a weaker effect on suicidal ideation.

Conclusion

Results emphasize that interventions aimed at improving positive emotions could have a protective effect on frail older people living alone in the community who are at risk of suicide.
Bridging the gap: how education transforms health outcomes and influences health inequality in rural China
Authors: Chen Jingyuan , Wei Longbao , Manzoor Faiza
Published: October 2024

This study focuses on the impact of education on health and health inequalities in rural areas of China. Education significantly enhances economic status and health, driving economic growth and improving public health standards. Integral to the “Healthy China Strategy,” it provides essential guidance for public policy and underscores the need for strategic human capital investments to achieve these goals. The study utilizes data from the China Family Panel Studies (CFPS) spanning 2010–2020 and employs the average educational level within counties as an instrumental variable. The causal impact of education on health and health inequalities is estimated using the two-stage least squares (2SLS) method. The findings reveal a significant positive correlation between enhancing education levels and health improvements. Specifically, after controlling for endogeneity, the duration of individual education significantly improves both subjective and objective health outcomes. It reduces health inequalities, with these effects being more pronounced among women and low-income groups. Mechanistically, education positively impacts health primarily by altering health behaviors and social network levels and reducing health inequalities through socio-economic factors. This paper provides important implications for public policy, suggesting that enhancing educational investments can drive economic development and improve population health standards.
Perceived protective behavioral changes in Chinese residents post-dynamic zero-COVID policy lifting: a cross-sectional study
Authors: Song Yuan-Yuan , Xu Ling , Liu Dan , Feng Mei , Yang Cui , Jiang Yan , Wu Ying
Published: October 2024

Objective

To investigate how Chinese residents perceived changes in their protective behaviors in the early stage after the lifting of the dynamic zero-COVID policy, and to explore the associations between the overall perceived change and factors such as demographic and health-related information, COVID-19 related perceptions, negative emotions, and coping styles.

Methods

This cross-sectional study involved 798 Chinese residents who completed an online questionnaire between 16 and 25 December 2022. The questionnaire covered demographic and health-related information, COVID-19 related perceptions, negative emotions, coping styles, and perceived changes in protective behaviors. Multiple linear stepwise regression analysis was used to determine the factors associated with the overall perceived change in protective behaviors.

Results

The mean score for perceived protective behavioral change among participants was 61.38 (SD = 10.20), which was significantly higher than the hypothesized no-change value of 49 (p < 0.001). The mean scores for each of the 15 behaviors (excluding the two vaccination-related items) were significantly greater than the hypothesized no-change value of 3 (p < 0.001). The mean scores for the two vaccination-related items were significantly greater than the hypothesized no-change value of 2 (p < 0.001). Among all behaviors, avoiding dining out or gathering with friends had the highest mean score (Mean = 4.16), while engaging in regular physical activity had the lowest (Mean = 3.32). Avoiding dining out or gathering with friends had the highest percentage of individuals reporting an increase (71.3%), whereas maintaining a social distance of more than 1 m had the highest percentage of individuals reporting a decrease (17.5%). Regression analysis indicated that age, worry, positive coping, female sex, negative coping, and perceived severity were associated with the overall perceived change in protective behaviors, with worry being the most predictive variable.

Conclusion

This study suggested that Chinese residents perceived an increase in their protective behaviors in the early stage after the policy change, with varying magnitudes across behaviors. We identified some potentially modifiable factors associated with perceived protective behavioral change, with worry emerging as the strongest predictor, followed by positive coping, negative coping, and perceived severity. These insights offer valuable information for developing effective communication strategies, psychological support, and comprehensive models in health behavior research.
The variability of competitive performance and pacing strategies in different rounds of the 400 m and 800 m freestyle swimming races at the 2017–2024 World Swimming Championships
Authors: Fang Junhui , Li Yunpeng , Cheng Yan
Published: October 2024

Introduction

This study aims to analyze the competitive performance and pacing strategies (PS) of medalists and non-medalists in different rounds of the 400 m and 800 m freestyle at the World Swimming Championships.

Method

The 2017–2024 World Swimming Championships and 161 elite swimmers were selected. First, intra-athlete coefficients of variability (CVs) were evaluated using linear mixed effects modeling and changes in competitive performance (Δ); second, descriptive statistics of position lap time; finally, a computer algorithm was used to obtain PS, then a two-way ANOVA was performed.

Result

(i) The PS was effective in 87.5% of the swimmers in the finals compared to the heats (CVs > 0.5%), but 73.8% of the males and 86.8% of the females showed an improvement in performance prior to the finals (Δ < 0); (ii) Gold medalists had an average position no lower than the top 2 and established themselves in the top 3 positions more than 90% of the time, aiming to remain in the top 3 until the final 100 m if they were to win a medal; (iii) The female swimmers in 400 m were more in the heats utilize the inverted-J (race velocity change curve profile as inverted-J), men for the fast-start-even, in the final, female remain the inverted-J, men change to the U-shaped (race velocity change curve profile as U-shaped), and in the 800 m, the swimmers were unified adopt the U-shaped.

Discussion

The elite swimmers who qualified for the finals performed better in the heats and semifinals because their PS were more effective. Others, however, did not have a chance to reach the finals because their PS efficiency was lower, and their competitive performance improved less or even regressed.
Evaluation of crop structure optimization policy quantitatively and future directions in China: a PMC-Index model approach
Authors: Su Ruiqing , Sui Hongjun , Ren Gaofeng , Wang Quanxi
Published: October 2024

Developing policies to optimize the planting structure is essential to ensure an adequate supply of agricultural products and guarantee food security. However, the rationality and comprehensiveness of China’s cropping structure optimization policies require scientific evaluation. Therefore, this research established an evaluation index system for China’s planting structure optimization policies using text mining and the PMC-Index model to evaluate eight agricultural cropping structure optimization policies in China since 2003. The results showed that: (1) The PMC-Index showed a general upward trend across the eight policies, with scores ranging from 4.88 to 6.61. (2) Seven of the eight policies were deemed acceptable, while one was classified as low. (3) The Chinese government has long focused on optimizing the structure of agricultural cultivation, and relevant policies have made significant progress in terms of logical connotation and long-term feasibility. However, there is still room for improvement in enhancing regulatory effectiveness and strengthening interdepartmental collaboration. It is recommended that the government develop more flexible and diverse incentive mechanisms, strengthen interdepartmental coordination, expand policy coverage, enhance the comprehensiveness of policy functions, and elevate support for agricultural technology.
Case Report: Postoperative ascites: allergic reaction to the drainage tube in a 12-year-old patient
Authors: Jiang Ren-sen , Lao Jing , Wang Huan-sheng , Wu Miao-bing , Wang Bing , Wang Jian-yao
Published: October 2024

Allergic reaction to the silicone is rare in children and as a result very little experience has been reported on symptom and treatment. We presented a case involving a child who experienced prolonged ascites following a surgery of placing an abdominal drainage tube, characterized by the ongoing drainage of clear, light-yellow fluid at a rate of 250 mL/day through the drainage tube for 36 days. Examination of the ascitic fluid revealed an abnormal elevation in eosinophil proportion, which exhibited positive response to anti-allergic treatment. Subsequent to the removal of the drainage tube, the ascites gradually resolved. In conclusion, we presented here the first and youngest case of allergic ascites associated with drainage tube after surgery of ovarian mucinous cystadenoma, it is imperative not to overlook the possibility of drainage tube allergy in the diagnostic process.
Cost-consequence analysis of the enhanced recovery after surgery protocol in major lung resection with minimally invasive technique (VATS)
Authors: Buja Alessandra , De Luca Giuseppe , Dal Moro Stefano , Mammana Marco , Zanovello Anna , Miola Stefano , Boemo Deris Gianni , Storti Ilaria , Bovo Pietro , Zorzetto Fabio , Schiavon Marco , Rea Federico
Published: October 2024

Background

ERAS is an evidence-based multimodal perioperative protocol focused on stress reduction and promoting a return to function. The aim of this work is to perform a cost-consequence analysis for the implementation of ERAS in major lung resection by means of minimally invasive surgery (VATS) from the public health service perspective, evaluating resource consumption and clinical outcomes with respect to a control group of past patients, which did not adopt an ERAS protocol.

Methods

Outcome differences (re-intervention rates, major and minor intraoperative and postoperative complications, readmissions, and mortality) as well as the costs of preoperative, operative, and postoperative care were estimated. The sample consisted of 64 consecutive patients enrolled in the ERAS programme between April 2021 and August 2022, compared to a control group (historical cohort) comprising 31 patients treated from April 2020 to December 2020, prior to the implementation of the ERAS programme. The study sample comprises patients who fulfil the established ERAS protocol inclusion criteria, including general criteria (acceptance of the protocol, proximity of residence, absence of contraindications to physiotherapy and early mobilisation), surgical criteria (anatomical lung resection up to lobectomy, absence of extensive resection, good possibility of conducting the operation in VATS) and anaesthesiologic criteria (ASA ≤2). Costs were quantified using the national health system perspective.

Results

The average length-of-stay was at least one day shorter in the ERAS group [<0.001. Average total costs including entire pathway healthcare costs were substantially reduced for ERAS-VATS patients (mean: € 5,955.71 vs. €6,529.41 Δ = −573.70 p = 0.018)]. Specifically, the median costs of the admission phase were significantly different between the two groups (median: €4,648.82 vs. €5,596.58, p = 0.008), with a reduction in hospital stay expenditure in the ERAS-VATS group (median: €1,599.62 vs. €2,399.43, p = 0.025). No significant differences were found regarding major clinical outcomes.

Conclusions

The implementation of an ERAS programme is a dominant strategy, representing an intervention capable of reducing overall costs in the context of elective anatomical lung resection with VATS without any significant differences in major complications and re-intervention rates.
Effects of a synergic interaction between magnesium sulphate and ketamine on the perioperative nociception in dogs undergoing tibial plateau leveling osteotomy: a pilot study
Authors: Galosi Margherita , Pennasilico Luca , Piccionello Angela Palumbo , Serino Federica , Tosi Francesca , Sassaroli Sara , Riccio Valentina , Angorini Alessio , Salvaggio Alberto , Di Bella Caterina
Published: October 2024

Introduction

Magnesium Sulphate (MgSO4) is commonly used in human medicine for the management of perioperative pain in different types of procedures. However, in veterinary medicine, the use of MgSO4 has not been evaluated for its analgesic efficacy in dogs, which has generated conflicts of opinion in this area of veterinary anesthesiology. The aim of this study was to evaluate the perioperative analgesic efficacy of MgSO4 in combination with Ketamine in dogs undergoing Tibial Plateau Leveling Osteotomy (TPLO). Our hypothesis is that MgSO4 plus ketamine have a synergistic action in the management of intra-and postoperative pain.

Methods

Twenty adult mixed breed dogs with average age 5.9 ± 2.6 years and weight 27.8 ± 9.2 kg were included in this prospective, clinical, randomized study. Dogs were randomly assigned to two groups. The MK group received ketamine (0.5 mg/kg as starting bolus followed by continuous infusion rate at 1 mg/kg/h). At the end of the ketamine bolus, MgSO4 (50 mg/kg over 15 min) was administered by the same route, followed by a constant rate infusion (CRI) at 15 mg/kg/h, IV. K group received a bolus of ketamine followed by a CRI at the same dosage described in MK group. Main cardiorespiratory parameters were recorded 10 min before the start of surgery (BASE), after the ketamine bolus (T1) and the MgSO4 bolus (T2), during the skin incision (SKIN), the osteotomy (OSTEOTOMY) and skin suturing (SUTURE). In the postoperative period, the short form of Glasgow Composite Pain scale (SF-CMPS) was used to assess pain at 30, 60, 120, and 180 min after extubation (Post30, Post60, Post120, and Post180, respectively). The main blood electrolytes (Mg2+, Ca2+, Na+, K+) were analyzed at BASE, T2, OSTEOTOMY, SUTURE and T3 (one hour after stopping MgSO4 infusion). Number of rescue analgesia and administration times were recorded both in the intra-and postoperative period.

Results

In K group 7 out of 10 dogs required intraoperatory rescue analgesia compared to MK group (3/10). Furthermore, mean arterial pressure (MAP) and heart rate (HR) were significantly higher at OSTEOTOMY compared to BASE time in both groups. In the postoperative period, at T120, ICMPS-SF score was higher in K group than MK group.

Conclusion

The administration of MgSO4 could guarantee better analgesia in the perioperative period in dogs undergoing TPLO, performing a synergistic action with ketamine.
Artificial intelligence-based automated determination in breast and colon cancer and distinction between atypical and typical mitosis using a cloud-based platform
Authors: Bakoglu Nilay , Cesmecioglu Emine , Sakamoto Hirotsugu , Yoshida Masao , Ohnishi Takashi , Lee Seung-Yi , Smith Lindsey , Yagi Yukako
Published: October 2024

Artificial intelligence (AI) technology in pathology has been utilized in many areas and requires supervised machine learning. Notably, the annotations that define the ground truth for the identification of different confusing process pathologies, vary from study to study. In this study, we present our findings in the detection of invasive breast cancer for the IHC/ISH assessment system, along with the automated analysis of each tissue layer, cancer type, etc. in colorectal specimens. Additionally, models for the detection of atypical and typical mitosis in several organs were developed using existing whole-slide image (WSI) sets from other AI projects. All H&E slides were scanned by different scanners with a resolution of 0.12–0.50 μm/pixel, and then uploaded to a cloud-based AI platform. Convolutional neural networks (CNN) training sets consisted of invasive carcinoma, atypical and typical mitosis, and colonic tissue elements (mucosa-epithelium, lamina propria, muscularis mucosa, submucosa, muscularis propria, subserosa, vessels, and lymph nodes). In total, 59 WSIs from 59 breast cases, 217 WSIs from 54 colon cases, and 28 WSIs from 23 different types of tumor cases with relatively higher amounts of mitosis were annotated for the training. The harmonic average of precision and sensitivity was scored as F1 by AI. The final AI models of the Breast Project showed an F1 score of 94.49% for Invasive carcinoma. The mitosis project showed F1 scores of 80.18%, 97.40%, and 97.68% for mitosis, atypical, and typical mitosis layers, respectively. Overall F1 scores for the current results of the colon project were 90.02% for invasive carcinoma, 94.81% for the submucosa layer, and 98.02% for vessels and lymph nodes. After the training and optimization of the AI models and validation of each model, external validators evaluated the results of the AI models via blind-reader tasks. The AI models developed in this study were able to identify tumor foci, distinguish in situ areas, define colonic layers, detect vessels and lymph nodes, and catch the difference between atypical and typical mitosis. All results were exported for integration into our in-house applications for breast cancer and AI model development for both whole-block and whole-slide image-based 3D imaging assessment.
Artistic Production in a Necropolis in Motion
Authors: Staring Nico
Published: October 2024

The present article studies aspects of the artistic production at New Kingdom Saqqara, a necropolis of the ancient Egyptian royal residence city Memphis. Following a brief review of the functions of ancient Egyptian tombs, this article will first set out to scrutinize the tomb-making section of society (e.g., size, membership). Second, the corpus of tombs will be reviewed to uncover the diverse nature of the tomb owners and to investigate access to resources required for tomb making. Third, the article will proceed to place the tombs in spatial and temporal context and reflect on the artistic production in a necropolis in motion.
Concept of Sporadic E Monitoring Using Space-Based Low Power Multiple Beacon-Systems
Authors: Vanhamel Jurgen , Berwaerts Marc , Speretta Stefano , Uludag Sevket
Published: October 2024

Current monitoring systems to detect sporadic E use ground-based setups, ionosondes, and the network of GNSS satellites in order to assess the phenomenon of sporadic E. This paper aims to monitor sporadic E using a miniature space-based platform in an atypical way. The setup consists of multiple radio-amateur beacon systems aboard satellites, each having a specific modulation and transmission scheme. This Radio Amateur Beacon System for the Investigation of the Ionosphere (RABSII) is coupled to a GNSS receiver, revealing the location of the platform. Multiple beacon data streams are sequentially sent from a satellite platform towards the Earth. By receiving and comparing the Signal-to-Noise ratios of these streams using a dedicated ground-based radio-amateur network of receiving stations, the presence of sporadic E can be determined, and a location-based model can be built. The advantage of this miniaturized, low-power, low-cost instrument is its ability to be put on any satellite platform in the future in order to map sporadic E.