bluuebunny/crossref_metadata_2025 huggingface dataset:
Area Deprivation Index in Patients with Invasive Lobular Carcinoma of the Breast: Associations with Tumor Characteristics and Outcomes
Authors: Kaur Mandeep , Patterson Anne , Molina-Vega Julissa , Rothschild Harriet , Clelland Elle , Ewing Cheryl A. , Mujir Firdows , Esserman Laura J. , Olopade Olufunmilayo I. , Mukhtar Rita A.
Published: May 2023

Background:

Although investigators have shown associations between socioeconomic status (SES) and outcomes in breast cancer, there is a paucity of such data for invasive lobular carcinoma (ILC), the second most common type of breast cancer. Herein we evaluated the relationship between SES with tumor features and outcomes in stage I to III patients with ILC.

Methods:

We analyzed a prospectively maintained institutional ILC database and utilized the area deprivation index (ADI) to determine neighborhood adversity, an indicator of SES. We used Cox proportional hazards models in Stata 17.0 to evaluate relationships between ADI quintile (Q), race, body mass index (BMI), clinicopathologic features, treatment type, and event-free survival (EFS).

Results:

Of 804 patients with ILC, 21.4% lived in neighborhoods classified as ADI Q1 (least resource-deprived) and 19.7% in Q5 (most resource-deprived). Higher deprivation was significantly associated with larger tumor size (3.6 cm in Q5 vs. 3.1 cm in Q1), increased presence of lymphovascular invasion (8.9% in Q5 vs. 6.7% in Q1), and decreased use of adjuvant endocrine therapy (67.1% in Q5 vs. 73.6% in Q1). On multivariable analysis, tumor size, receptor subtypes, and omission of adjuvant endocrine therapy were associated with reduced EFS.

Conclusions:

These data show that patients with ILC and higher ADI experience more aggressive tumors and differences in treatment. More data evaluating the complex relationships between these factors is needed to optimize outcomes for patients with ILC, regardless of SES.

Impact:

ADI is associated with differences in patients with ILC.
Prediagnostic 25-Hydroxyvitamin D in Association with Cancer-specific and All-cause Mortality among Low-income, Non-Hispanic Black Americans with Colorectal Cancer
Authors: Lawler Thomas P. , Khankari Nikhil K. , Shu Xiao-Ou , Steinwandel Mark , Cai Qiuyin , Jurutka Peter W. , Zheng Wei , Warren Andersen Shaneda
Published: May 2023

Background:

Observational studies show high prediagnosis 25-hydroxyvitamin D is associated with lower mortality after colorectal cancer diagnosis. Results from clinical trials suggest vitamin D supplementation may improve outcomes among patients with colorectal cancer. Most studies included few Black Americans, who typically have lower 25-hydroxyvitamin D. We evaluated associations between serum 25-hydroxyvitamin D and mortality after colorectal cancer diagnosis among Black American cases.

Methods:

Data arose from 218 Black Americans from the Southern Community Cohort Study diagnosed with colorectal cancer during follow-up (age 40–79 at enrollment). Prediagnostic 25-hydroxyvitamin D was measured at enrollment and categorized as deficient (<12 ng/mL), insufficient (12–19.9 ng/mL), or sufficient (≥20 ng/mL). Mortality was determined from the National Death Index. Cox proportional hazards were used to estimate HRs and 95% confidence intervals (CI) for associations between 25-hydroxyvitamin D and mortality.

Results:

As a continuous exposure, higher 25-hydroxyvitamin D was associated with overall mortality [HR = 0.79 (0.65–0.96) per-SD increase, Ptrend = 0.02] and colorectal cancer–specific mortality [HR = 0.83 (0.64–1.08), Ptrend = 0.16]. For overall mortality, associations were strongest among females [HR = 0.65 (0.42–0.92)], current smokers [HR = 0.61 (0.38–0.98)], and obese participants [HR = 0.47 (0.29–0.77)]. Compared with those with deficiency, participants with sufficient 25-hydroxyvitamin D had lower overall mortality after multivariable adjustment [HR: 0.61 (0.37–1.01)].

Conclusions:

Prediagnosis 25-hydroxyvitamin D is inversely associated with overall and colorectal cancer–specific mortality among Black Americans with colorectal cancer. Correcting vitamin D deficiency may improve survival of these patients, particularly for obese individuals and smokers.

Impact:

Our results support including more Black Americans in trials of vitamin D supplementations to improve colorectal cancer outcomes.
Systolic Blood Pressure Control Targets to Prevent Major Cardiovascular Events and Death in Patients With Type 2 Diabetes: A Systematic Review and Network Meta-Analysis
Authors: Yang Qianqian , Zheng Ruizhi , Wang Siyu , Zhu Jiamin , Li Mian , Wang Tiange , Zhao Zhiyun , Xu Min , Lu Jieli , Chen Yuhong , Ning Guang , Wang Weiqing , Bi Yufang , Xu Yu
Published: May 2023

BACKGROUND:

Previous meta-analyses using traditional pairwise comparisons did not support intensive systolic blood pressure (SBP) control in patients with diabetes and included trials published before 2015. We aimed to identify the optimal SBP control targets in patients with type 2 diabetes using a systematic review and network meta-analysis of accumulating evidence.

METHODS:

We systematically searched PubMed, Embase, and Cochrane Library from inception to August 29, 2022 for randomized controlled trials comparing different blood pressure targets, antihypertensive agents against placebo, or dual antihypertensive agents against single agent in patients with type 2 diabetes. Network meta-analysis was used to obtain pooled results of direct and indirect comparisons of each 5 mm Hg SBP category in association with clinical outcomes adjusted for baseline risk and intervention duration (PROSPERO [International Prospective Register of Systematic Reviews], CRD42022316697).

RESULTS:

We identified 30 trials including 59 934 patients with type 2 diabetes. The mean achieved SBP levels ranged from 117 mm Hg to 144 mm Hg among treatment groups. A total of 7799 major cardiovascular diseases events and 4130 deaths were reported. The lowest risk of major cardiovascular diseases was found in patients with achieved SBP level of 120 to 124 mm Hg. The hazard ratio and 95% CI were 0.73 (0.52–1.02) compared with 130 to 134 mm Hg, 0.60 (0.41–0.85) compared with 140 to 144 mm Hg, and 0.41 (0.26–0.63) compared with ≥150 mm Hg. Similar results were found for cardiovascular diseases components including stroke, myocardial infarction, heart failure, and cardiovascular death. All-cause death was reduced at an achieved SBP <140 mm Hg but further reduction did not show additional benefits.

CONCLUSIONS:

Our findings support an intensive blood pressure-lowering strategy to prevent major cardiovascular diseases in patients with type 2 diabetes.
Two new species of Tibouchina (Melastomataceae) from the Brazilian Cerrado
Authors: SCHMITZ MEYER FABRÍCIO , DE OLIVEIRA DINIZ DANIELLE , KLOSTERMANN ZIEMMER JULIANA , GOLDENBERG RENATO
Published: May 2023

We describe here two new species of Tibouchina from the Brazilian Cerrado. Tibouchina falcifolia is endemic to the state of Goiás and it can be readily recognized by the lanceolate to linear, conduplicate, pendulous leaves, and very conspicuous hypanthium scales. It is morphologically related to Tibouchina aegopogon var. angustifolia, especially by the narrow leaves, but differs by the older branches decorticant (vs. older branches non-decorticating), slightly discolorous leaves (vs. strongly discolorous leaves), with the adaxial surface covered by trichomes (vs. covered by scales). Tibouchina longisquamata is a species endemic to the state of Tocantins and it can be readily recognized by the oval, flat, patent leaves and hypanthium with long scales. It shares with Tibouchina llanorum the oval, slightly discolorous leaves, with a conspicuous petiole, and hypanthium covered with long scales. Tibouchina longisquamata differs from T. llanorum by its subcylindrical branches (vs. 4-6 angulose) and leaves with the adaxial surface covered by trichomes (vs. covered by scales). According to our assessments, based on IUCN criteria, T. falcifolia must be considered as endangered (EN) because its occurrence is restricted, and its populations are small; T. longisquamata is indicated in Deficient Data (DD), with only two known collections. We present here complete descriptions of the new species, taxonomic comments, illustrations made from dehydrated material, photos of live specimens (for T. falcifolia), plates with microscopic details, a distribution map, and an updated list of species of the genus in the Brazilian Cerrado, with its occurrences by state.
A review of the American species of Xenelmis Hinton (Coleoptera: Elmidae), with a new species from Argentina
Authors: MANZO VERÓNICA
Published: May 2023

The genus Xenelmis Hinton is taxonomically reviewed. A new species of riffle beetle from Argentina, Xenelmis uruzuensis sp. nov. is described and illustrated from adults of both sexes and the larva. Ten additional species of Xenelmis are treated: X. sandersoni Brown, X. bufo (Sharp), X. rufipes Delève, X. leechi Perkins & Steiner, X. marcapata Perkins & Steiner, X. tarsalis Hinton, X. teres Hinton, X. audax Hinton, X. comis Hinton and X. laura Brown. Male genitalia of each species are illustrated, some of them for the first time. Distributional records, diagnoses and a key to distinguish the species of Xenelmis are included.
Taxonomic notes on the ant-eating spider genera Asceua Thorell, 1887 and Cydrela Thorell, 1873 from India, with comment on Indian species of Euryeidon Dankittipakul & Jocqué, 2004 (Araneae: Zodariidae)
Authors: SANKARAN PRADEEP M.
Published: May 2023

Indian species of the ant-eating spider genera Asceua Thorell, 1887, Cydrela Thorell, 1873 and Euryeidon Dankittipakul & Jocqué, 2004 are reviewed. The species Asceua cingulata (Simon, 1905) is redescribed and illustrated based on type and freshly collected material and a new species, A. thrippalurense sp. nov. is described and illustrated based on both sexes. All the Indian Cydrela species are transferred back to the genus Capheris Simon, 1893 under which these were originally placed. The species Capheris escheri Reimoser, 1934 comb. rest. and Caph. stillata Simon, 1905 comb. rest. are redescribed and illustrated, the former based on its type specimen, while the latter based on freshly collected material. The species Capheris nitidiceps Simon, 1905 comb. rest. is considered as a nomen dubium due to the immature stage of the holotype. The two Indian species of Euryeidon are transferred to the genus Laminion Sankaran, Caleb & Sebastian, 2020 due to generic similarities. The distribution of all these species is mapped.
Charlas y Comidas: Humanising focus groups and interviews
Authors: Ortega Yecid
Published: May 2023

Qualitative research has utilised focus groups and interviews to gather information from participants while conducting ethnographic research. This article explores the potential of alternative forms of collecting data that are more in line with the participants’ feelings, emotions and expectations. Charlas (chats) and Comidas (meals) were utilised in an ethnographic study with English teachers and their students in marginalised high schools in Bogotá, Colombia. I found that opening a safe space for participants to share their ideas, suggestions and comments while chatting informally or having a meal encourages leadership of the research process. This generated a sentiment of trust and bond which strengthen their sense of belonging to their academic community. This article contributes to the literature on alternative, critical and decolonial forms of doing research by considering ways to implement methods that acknowledge the cultural and linguistic backgrounds of the participants which strengthen humanising relationships, especially in marginalised contexts.
The first positive evidence that training improves triage decisions in Greece: evidence from emergency nurses at an Academic Tertiary Care Emergency Department
Authors: Zagalioti Sofia-Chrysovalantou , Fyntanidou Barbara , Exadaktylos Aristomenis , Lallas Konstantinos , Ziaka Mairi
Published: May 2023

Background

Triage refers to the process of patient prioritisation in the emergency department (ED). This is based on the severity of the patient’s illness and is performed by emergency nurses (ENs). This has a pivotal role in ensuring patient safety and in ensuring that the ED operates smoothly – so continuous and accurate training are essential. As Emergency Nursing has been formally established in Greece since 2019, it is of the uppermost importance that all Greek ENs should be trained in the use of a standardised triage system. The present study aimed to evaluate the effect of triage training of ENs in the use of the Swiss Triage System (STS) after an intervention of one week.

Methods

The effect of triage training was studied experimentally by comparing performance before and one week after training. A sample of thirty-six ENs from the University Department of Emergency Medicine at AHEPA University Hospital took part. The role of training in triage by the STS was assessed by completing the same self-administered questionnaire before and after a 45-minute e-learning program (presentation video of STS but with simulation scenarios) which was available during the period of a week. The post-training test was taken 2 weeks later, after the training process.

Results

The most promising finding was that there was a significant improvement in the number of correct answers after the training in triage (p<0.001). A significant improvement was also detected (p<0.001) in the questions that tested vigilance in providing safe health services by ENs, whereas there was no significant association between the number of correct answers and years of emergency experience or level of education, - either before or after the intervention.

Conclusions

Triage training seems to successfully improve effective and efficient triage. To the best of our knowledge, this is the first study that has demonstrated that triage training has a significant positive impact on triage performance by ENs in Greece. It is planned to support these findings by real time studies in an ED.
Association of depressive symptoms with Geriatric Locomotive Function Scale score in community-dwelling older adults living in the state of emergency
Authors: Imaoka Masakazu , Nakamura Misa , Tasaki Fumie , Inoue Takao , Orui Junya , Imai Ryota , Hida Mitsumasa , Nakao Hidetoshi , Takeda Masatoshi
Published: May 2023

Background

Under the state of emergency, it has been reported that the amount of physical activity among community-dwelling older adults has decreased significantly due to refraining from going out, and there are strong concerns about the Geriatric Locomotive Function Scale and deterioration of mental health. Therefore, this study aimed to investigate whether the depressive state before the coronavirus disease 2019 (COVID-19) pandemic affected the 25-Geriatric Locomotive (GLFS) score during the COVID-19 pandemic among community-dwelling older adults.

Methods

The participants were 194 community-dwelling older adults (45 men, 149 women) with an average age of 75.5 ± 5.5 years who responded to a self-administered survey conducted three times (preliminary, second, and third) from before the 2018 COVID-19 pandemic to March 2021. Individuals with a score of ≥ 10 on the Geriatric Depression Scale 15 (GDS 15) were excluded. The survey items included the 25-question Geriatric Locomotive Function Scale (GLFS25), GDS 15, and other basic attributes. Those with scores of 5 to 9 on the GDS 15 and those with scores of 0 to 4 were assigned to the depressive symptoms (DS) group and the non-DS group, respectively. Statistical analysis was performed using two-way analysis of variance. The Mann–Whitney U test was used for comparisons between the groups.

Results

In total, 187 patients were included in the analysis, excluding 7 patients. GLFS 25 showed a significant increase in scores at the second and third time points compared with baseline, and a main effect was confirmed in both groups, with no interaction effect. The second time, the score was 10.0 ± 8.5 and 13.7 ± 10.5 in the non-DS and DS groups, respectively. The third time, the non-DS and DS groups scored 10.8 ± 10.5 and 14.9 ± 10.1 points, respectively, indicating a significant difference.

Conclusions

Our results revealed that the increase in the GLFS 25 score in community-dwelling older adults during the COVID-19 pandemic was related to their DS during normal times before the pandemic. Evaluating such individuals and providing social support may effectively reduce the deterioration of the GLFS 25 score.
The burden of musculoskeletal disorders in the Middle East and North Africa (MENA) region: a longitudinal analysis from the global burden of disease dataset 1990—2019
Authors: Al-Ajlouni Yazan A. , Al Ta’ani Omar , Mushasha Rand , Lee Justin Lin , Capoor Jaishree , Kapadia Mitul R. , Alejandro Ruth
Published: May 2023

Background

Musculoskeletal (MSK) disorders are one of the main causes of disability among adults globally. The burden of MSK disorders varies greatly between different regions and is the highest in low- and middle income- countries. This study sought to investigate trends in the burden of MSK disorders across the MENA region, utilizing the GBD 2019 dataset.

Methods

This ecological study utilized data from the Global Burden of Disease (GBD) to report on the burden of musculoskeletal (MSK) disorders in The Middle East and North Africa (MENA) region between 1990 and 2019. Our analysis involved descriptive statistics and sociodemographic trends and did not employ any specific statistical analyses. Using age-standardized rates of prevalence and disability-adjusted life-years (DALYs), we reported trends in the burden of MSK disorders, as well as national variation between different countries. Furthermore, we analyzed trends in risk factors contributing to MSK disorders by age and gender.

Results

The longitudinal analysis from 1990 to 2019 showed an increase in the age-standardized rate for prevalence and DALYs of MSK disorders by 5% and 4.80%, respectively. Low back pain continued to be the most prevalent MSK condition, while RA and other MSK disorders had the largest percentage increase for DALYs between 1990 and 2019. The study found that Afghanistan had the lowest age standardized DALYs rate attributed to MSK disorders, while Iran, Turkey, and Jordan had the highest. Further, Syria showed the most dramatic decrease while Saudi Arabia had the most notable increase in age standardized DALY rates from 1990 to 2019. In 2019, occupational risks, high body mass index, and tobacco smoking were the main risk factors for MSK disorders, with occupational risks being the largest contributor, and between 1990 and 2019, there was a decrease in the contribution of occupational risks but an increase in the contribution of high body mass index as a risk factor.

Conclusion

This study highlights the significant burden of MSK disorders in the MENA region, with various risk factors contributing to its increasing prevalence in recent decades. Further research is needed to better understand the underlying factors and potential interventions that could improve health outcomes. Addressing MSK disorders should be a public health priority in the region, and efforts should be made to develop effective strategies to prevent and manage this debilitating condition.
Aseptic loosening of tumor prostheses in distal femur after revision surgery: a retrospective study
Authors: Li Ziming , Yu Xiuchun , Xu Ming , Zheng Kai , Hou Ziwei , Miao Zukang , Sun Yanshun
Published: May 2023

Background

Tumor prostheses of the distal femur after revision surgery is associated with high rates of aseptic loosening, which has introduced great challenges to the survival of patients, but only a few studies have evaluated their X-ray imaging. The purpose of this study was to analyze the risk factors for recurrence of aseptic loosening and make recommendations to reduce the incidence of aseptic loosening after revision surgery of tumor prostheses in the distal femur.

Method

A retrospective analysis was performed on 23 patients who had revision surgery for distal femur prostheses due to aseptic loosening between June 2002 and June 2021. They were divided into two groups based on the condition of the prostheses after revision surgery: loosening group (9 patients) and control group (14 patients). Following the initial replacement, the length and diameter of the prosthetic intramedullary stem were measured through the standard full-length anteroposterior X-ray imaging of both lower limbs. The osteotomy length, femoral length and diameter, femoral intramedullary stem diameter, hip-knee-ankle angle (HKAA), mechanical lateral distal femoral angle (mLDFA), mechanical medial proximal tibial angle (mMPTA), and so on were measured as well. Following that, statistical analysis was performed.

Results

Patients in the loosening group had statistically significant differences in the ratio of prostheses length to femur length (71.89 ± 6.62) and the ratio of intramedullary stem diameter to femoral diameter (25.50 ± 6.90) (P < 0.05), when compared to the control group. The HKAA (175.58 ± 2.78), mLDFA (94.42 ± 2.57), and the deviation angle between the lower limb alignment and the tibial prostheses force line (2.23 ± 1.09) in the loosening group were significantly different from those in the control group (P < 0.05) on postoperative radiographs of the entire length of the lower limbs. The lowest score in intramedullary manubrium I indicated less osteolysis, while the highest score in intramedullary manubrium III indicated the most serious osteolysis, and the difference was statistically significant (P < 0.05).

Conclusions

Our study suggests that the use of longer and thicker intramedullary stems can effectively decrease the occurrence of aseptic loosening. Additionally, it is important to avoid using the original prostheses and reconstruct the standard line of lower limb force to further reduce the incidence of aseptic loosening. It is crucial to closely monitor the distal segment of the intramedullary stem for osteolysis after surgery.
Leveraging community health workers as vaccinators: a case study exploring the role of Malawi’s Health Surveillance Assistants in delivering routine immunization services
Authors: Alban Rebecca , Gibson Emily , Payne Jenny , Chihana Tafwirapo
Published: May 2023

Background

Global chronic health worker shortages and stagnating routine immunization rates require new strategies to increase vaccination coverage and equity. As trained, trusted members of their local communities, community health workers (CHWs) are in a prime position to expand the immunization workforce and increase vaccination coverage in under-reached communities. Malawi is one of only a few countries that relies on CHWs—called Health Surveillance Assistants (HSAs) in Malawi—to administer routine immunizations, and as such offers a unique example of how this can be done.

Case presentation

We sought to describe the operational and programmatic characteristics of a functional CHW-led routine immunization program by conducting interviews with HSAs, HSA supervisors, ministry of health officials, and community members in Malawi. This case study describes how and where HSAs provide vaccinations, their vaccination-related responsibilities, training and supervision processes, vaccine safety considerations, and the community-level vaccine supply chain. Interview participants consistently described HSAs as a high-functioning vaccination cadre, skilled and dedicated to increasing vaccine access for children. They also noted a need to strengthen some aspects of professional support for HSAs, particularly related to training, supervision, and supply chain processes. Interviewees agreed that other countries should consider following Malawi’s example and use CHWs to administer vaccines, provided they can be sufficiently trained and supported.

Conclusions

This account from Malawi provides an example of how a CHW-led vaccination program operates. Leveraging CHWs as vaccinators is a promising yet under-explored task-shifting approach that shows potential to help countries maximize their health workforce, increase vaccination coverage and reach more zero-dose children. However, more research is needed to produce evidence on the impact of leveraging CHWs as vaccinators on patient safety, immunization coverage/vaccine equity, and cost-effectiveness as compared to use of other cadres for routine immunization.
Simultaneous operations for gastric cancer and aortic aneurysm: a case report
Authors: Komarov Roman , Osminin Sergey , Chernyavsky Stanislav , Ivashov Ivan
Published: May 2023

Background

Gastric cancer is the second highest cause of morbidity among malignant tumors of the gastrointestinal tract and fifth in overall cancer statistics. Diseases of the cardiovascular system are the leading causes of death in the world. Aneurysm of the abdominal aorta is the most common type of vascular aneurysm, while in 75% of the cases it is asymptomatic. The risk of rupture of aneurysm of the abdominal aorta increases progressively depending on its diameter and the age of the patient.

Case presentation

A 56-year-old male patient underwent treatment for complaints of pain and discomfort in the epigastric region, general weakness and difficulty in passing food through the esophagus. The neoplasm extended to the esophagus up to 17–20 mm (pT3N3aM0 R0 stage IIIB TNM 8). The aortic diameter at the level of the renal arteries was 18 mm; lower than the main renal arteries, an expansion of up to 60 mm was visualized; the length of aneurysm was 105 mm extending to the bifurcation. A gastrectomy with a resection of the lower thoracic esophagus and application of a manual double-row Roux-en -Y esophagojejunal anastomosis with cholecystectomy and D2 lymphadenectomy was done along with longitudinal aneurysmectomy and thrombectomy. The proximal anastomosis between the aorta and the synthetic linear prosthesis of 18 × 9 × 9 mm in the end-to-end type was formed by a continuous winding suture with the “Prolene” 5-0 thread. The end-to-end distal anastomosis of the prosthesis and aorta branch was formed by continuous winding suture with the “Prolene” 6-0 thread. The postoperative period proceeded without features and complications. On the 7th day after the surgery, the patient was discharged home in satisfactory condition.

Conclusions

Performing a simultaneous operation allowed the patient to undergo rehabilitation after the treatment of two diseases during one hospitalization and, in the shortest possible time, to proceed to the next stage of gastric cancer treatment—chemotherapy, thereby improving the prognosis of life expectancy. Also, one-stage surgical treatment of concomitant aneurysm of the abdominal aorta and gastric cancer is well tolerated and can avoid financial costs, and patient anxiety involved in a second operation.
ALS-linked FUS R521C disrupts arginine methylation of UBAP2L and stress granule dynamics
Authors: Jun Mi-Hee , Lee Sang-Hee , Huh Yang Hoon
Published: May 2023

Mutations in the fused-in-sarcoma (FUS) gene have been linked to familial amyotrophic lateral sclerosis (fALS). FUS aggregates in the cytosol and associates with stress granules (SGs) in pathological cases, whereas FUS is normally found in the nucleus. However, little is known about how FUS mutations cause neurodegeneration in ALS, which is distinguished by FUS-positive inclusion and stress granules. In this study, we investigated the mechanism of abnormal cytoplasmic aggregate formation caused by ALS-linked FUS mutations. FUS R521C interacted more with ubiquitin-associated protein 2-like (UBAP2L) and protein arginine methyltransferase 1 (PRMT1) than FUS WT, and PRMT1 and UBAP2L are sequestered into FUS R521C-positive stress granules under oxidative stress. PRMT1 asymmetrically demethylates UBAP2L, which is required for both SG assembly and disassembly. Furthermore, in FUS R521C, arginine methylation of UBAP2L is reduced, and the loss of PRMT1 increases FUS-positive SGs in oxidative stress. These results imply that an aberrant interaction between FUS-R521C and PRMT1 causes insufficient arginine methylation of UBAP2L, resulting in abnormal FUS-R521C-positive SGs remaining in the cytoplasm. This study could lead to the identification of a new pathogenic mechanism and therapeutic targets for the FUS mutation, which has been associated with abnormally increased protein interactions in ALS.

Graphical abstract
Essential role of ATG7 in LPS-induced endometrial inflammatory injury in goats
Authors: Jiang Tingting , Yin Xueting , Chen Jianguo
Published: May 2023

The economic losses caused by uterine infections in ruminants have received increasing attention. Autophagy-related 7 (ATG7) has been demonstrated to be capable of regulating apoptosis, but surprisingly, ATG7 can both promote and inhibit apoptosis in different cellular contexts. However, the role of ATG7 in endometrial cell apoptosis during the postpartum period remains unclear. Herein, the location and expression of ATG7 was determined after mice were treated with lipopolysaccharide (LPS) in the uterus. The results showed that lipopolysaccharide (LPS) increased ATG7 expression in endometrial epithelial cells (EECs) but not endometrial stromal cells. The apoptosis of goat EECs was increased under LPS treatment, and LPS further led to an increase in bax expression and a decline in bcl-2 expression in goat EECs. Silencing of ATG7 inhibited goat EEC apoptosis with LPS treatment. The role of ATG7 in the regulation of goat EEC apoptosis was further confirmed by overexpression. ATG7 may serve as an essential regulatory factor in the process of endometrial epithelial cell apoptosis in ruminants under inflammatory injury. The findings help elucidate the pathogenesis of postpartum endometritis in ruminants.
How to Subvert the Banking Concept of Education in Neoliberal Times
Authors: Bezio Kelly L.
Published: May 2023

This article discusses a resurgent banking concept of education laid bare by the coronavirus pandemic. It uses the theories of Paulo Freire, Mark Fisher, Michel Foucault, and Saidiya Hartman to articulate how learning-management systems undermine literary study's problem-posing educational paradigm and how to retain it amid increasing technocratic pressures.
“Indeed Strangely Altered”
Authors: Gliserman-Kopans Dana
Published: May 2023

Daniel Defoe's Journal of the Plague Year documents the cultural changes that the plague brings about in London. The COVID-19 pandemic similarly brought about dramatic cultural changes, and it changed the way that faculty taught. This article argues that faculty were forced to rethink what they teach, why they teach, and how they teach, and English departments and departments across higher education can serve students better if they retain the lessons that learned in the post-pandemic context.
The Stoner Book Club
Authors: Kangas William
Published: May 2023

With decades of newspaper reporting behind him, the author took a mid-life pivot to teaching that started as a high school substitute. He describes how a student's question about life in the eighties triggers a flashback to a day that gave his life meaning and direction after a chance encounter with a group of troublemakers. They offer him a nonfiction book about a band that seemed like they were from another world. As a result, the author grew wiser that day and decided he would try to change the world as a journalist, writing about people and places that needed discovery. The story proves inspiration can come from the most unlikely place— and all it takes is one book or one song for life to change course.
Shelley's Frankenstein
Authors: Baxter Ryan
Published: May 2023

This “reading memoir” narrates the manner in which the writer's recurrent encounters with Mary Shelley's Frankenstein have led to a prospective career in the humanities.
The Common-Probability Auction Puzzle
Authors: Ngangoué M. Kathleen , Schotter Andrew
Published: May 2023

This paper presents a puzzle in the behavior of experimental subjects in what we call common-probability auctions. In common-value auctions, uncertainty is defined over values, while in common-probability auctions, uncertainty is defined over probabilities. We find that in contrast to the substantial overbidding found in common-value auctions, bidding in strategically equivalent common-probability auctions is consistent with Nash equilibrium. To explain our results, we run treatments to identify whether this difference stems from the way subjects estimate the good’s value in a competitive environment rather than the way they bid conditional on these valuations. We conclude it is the former. (JEL C70, C90, D44, D81)
Optimal Contracting with Altruistic Agents: Medicare Payments for Dialysis Drugs
Authors: Gaynor Martin , Mehta Nirav , Richards-Shubik Seth
Published: May 2023

We study health-care provider agency and optimal payments, considering an expensive medication for dialysis patients. Using Medicare claims data we estimate a structural model of treatment decisions, in which providers differ in their altruism and marginal costs, and this heterogeneity is unobservable to the government. In a novel application of nonlinear pricing methods, we empirically characterize the optimal contracts in this environment. The optimal contracts eliminate medically excessive dosages and reduce expenditures, resulting in approximately $300 million in annual gains from better contracting. This approach could be applied to a broad class of problems in health-care payment policy. (JEL D64, D86, H51, I11, I13, J33, L21)
Φαινότυποι συνδρόμου υπνικής άπνοιας σε ασθενείς πρωτοβάθμιας φροντίδας υγείας (Π.Φ.Υ.)
Authors: Ντέντα Παναγιώτα
Published: May 2023

Εισαγωγή: Το Σύνδρομο Αποφρακτικής Άπνοιας στον Ύπνο (ΣΑΑΥ) είναι μια ετερογενής διαταραχή ύπνου κι αποτελεί πρόβλημα Δημόσιας Υγείας. Επιδημιολογικές μελέτες στο γενικό πληθυσμό δείχνουν ότι ο επιπολασμός είναι περίπου 5% -10%. Σκοπός: Σκοπός της εργασίας ήταν να προσδιοριστούν οι φαινότυποι συννοσηρότητας σε ασθενείς με ΣΑΑΥ που αναφέρονται στο σύστημα Πρωτοβάθμιας Φροντίδας Υγείας (ΠΦΥ). Μεθοδολογία: Εγγράψαμε 1496 ασθενείς που αναφέρθηκαν στο σύστημα Π.Φ.Υ. για οποιοδήποτε πρόβλημα του αναπνευστικού συστήματος ή ύπνου, για την περίοδο μεταξύ Νοεμβρίου 2015 και Σεπτεμβρίου 2017. Ο πληθυσμός της μελέτης υποβλήθηκε σε αξιολόγηση με πολυσωμοτοκαταγραφική μελέτη ύπνου (PSG) στην Κλινική Ύπνου του διασυνδεδεμένου Γενικού Νοσοκομείου, προκειμένου να διαγνωστεί το σύνδρομο. Στην ανάλυση συμπεριλήφθηκαν 136 ασθενείς. Η ποσοτικοποίηση της σοβαρότητας της συννοσηρότητας αξιολογήθηκε χρησιμοποιώντας τον δείκτη συννοσηρότητας Charlson (CCI). Πραγματοποιήθηκε ανάλυση κύριων συνιστωσών και η ομαδοποίηση δύο βημάτων για τον προσδιορισμό διακριτών ομάδων στον πληθυσμό της μελέτης. Οι πολυπαραγοντικές συγκρίσεις μεταξύ συστάδων πραγματοποιήθηκαν με τη μέθοδο one-way ANOVA με post-hoc Bonferroni διόρθωση και τη δοκιμασία x2 τεστ του Pearson. Αποτελέσματα: Η ανάλυση έδειξε τρεις συστάδες. Η πρώτη περιελάμβανε ασθενείς με μέτριου βαθμού ΣΑΑΥ, παχυσαρκία, υψηλή βαθμολογία ESS, χωρίς σημαντική συννοσηρότητα. Η δεύτερη περιελάμβανε ασθενείς με σοβαρού βαθμού ΣΑΑΥ, σοβαρή παχυσαρκία με συννοσηρότητα και την υψηλότερη βαθμολογία ESS (11,6±3,99) και η τρίτη περιελάμβανε ασθενείς με σοβαρού βαθμού ΣΑΑΥ, παχυσαρκία χωρίς συννοσηρότητα, αλλά με υψηλή βαθμολογία ESS. Οι συστάδες διέφεραν ως προς την ηλικία (p<0,005), στο Δείκτη Μάζας Σώματος, στο δείκτη άπνοιας – υπόπνοιας, το δείκτη αποκορεσμού οξυγόνου, το δείκτη διέγερσης, το δείκτης αναπνοής και διέγερσης αποκορεσμού (p<0,0001). Συμπεράσματα: Τα προγνωστικά μοντέλα συννοσηρότητας μπορούν να βοηθήσουν στην έγκαιρη διάγνωση των ασθενών σε κίνδυνο και να ανοίξουν το δρόμο για εξατομικευμένη θεραπεία.
Effects of the administration of phenolic compounds of olives on anthropometric and metabolic indices in women with overweight and obesity
Authors: Φυτιλή Χριστίνα
Published: May 2023

Η υδροξυτυροσόλη (ΥΤ) αποτελεί μια από τις σημαντικότερες φαινόλες που ανευρίσκονται στις εδώδιμες ελιές και στο εξαιρετικά παρθένο ελαιόλαδο. Οι διαθέσιμες μελέτες εξαίρουν τις πλειοτροπικές δράσεις της οι οποίες ασκούνται μέσω της μείωσης του οξειδωτικού stress σε πολλαπλά επίπεδα. Συγκεκριμένα, η αντιοξειδωτική της δράση έχει μελετηθεί σε πειραματικές μελέτες σε κυτταρικό επίπεδο, στα μυοκύτταρα, τα ηπατοκύτταρα, τα παγκρεατικά κύτταρα, τα αδιποκύτταρα αλλά και σε πειραματόζωα, όπου αναδεικνύεται η ικανότητα της υδροξυτυροσόλης να μειώνει τη λιπώδη διήθηση του ήπατος, να ευοδώνει τη λιπόλυση, να βελτιώνει το λιπιδαιμικό προφίλ και την ομοιόσταση της γλυκόζης, τροποποιώντας το εντερικό μικροβίωμα, βελτιώνοντας το οξειδωτικό stress και αρκετούς δείκτες φλεγμονής σε αρκετές μελέτες. Στους ανθρώπους έχει συσχετιστεί με βελτίωση στο λιπιδαιμικό προφίλ και την οξείδωση των λιποπρωτεϊνών, στην ινσουλινοευαισθησία και λόγω της δράσης της κατά της συσσώρευσης αμυλοειδούς, η δράση της μελετάται επίσης και σε νευροεκφυλιστικές νόσους. Οι διαθέσιμες μελέτες χρησιμοποιούν κυρίως υψηλές δόσεις ΥΤ και για σύντομο χρονικό διάστημα. Στην παρούσα μελέτη χορηγήθηκε για πρώτη φορά για 24 εβδομάδες ΥΤ σε γυναίκες με υπερβαρότητα και παχυσαρκία σε συνδυασμό με διαιτητική παρακολούθηση και σύσταση για άσκηση, με στόχο τη διερεύνηση της πιθανής επίδρασης της ΥΤ στη βελτιστοποίηση της σύστασης του σώματος, ενώ παράλληλα μελετήθηκαν οι μεταβολές στη γλυκόζη, την ινσουλίνη, το λιπιδαιμικό προφίλ και άλλους δείκτες καρδιαγγειακού κινδύνου, και τέλος, η αντίληψη κορεσμού και πείνας. Η μελέτη ήταν διπλά τυφλή και τυχαιοποιημένη, με 2 ομάδες στην ομάδα παρέμβασης, στην οποία χορηγήθηκαν 15mg ΥΤ με τη μορφή καψουλών στις ασθενείς με αρχικά υψηλό ποσοστό σωματικού λίπους (>40%) και 5mg ΥΤ στις ασθενείς με χαμηλότερο, αν και υψηλό ποσοστό σωματικού λίπους (<40%), και η σύγκριση έγινε με την ομάδα που έλαβε αδρανή ουσία. Η στατιστική ανάλυση μεταξύ των ομάδων παρέμβασης και placebo έγινε μόνο στις συμμετέχουσες με επαρκή συμμόρφωση και δεν ανέδειξε στατιστικά σημαντικές διαφορές στις μελετώμενες παραμέτρους μεταξύ των ομάδων παρέμβασης και placebo, ενώ η μεταξύ των υποομάδων ανάλυση έδειξε στατιστικά σημαντική υπεροχή της ομάδας που έλαβε υψηλή δόση ΥΤ (15mg) έναντι placebo ως προς την απώλεια βάρους και σπλαγχνικού λίπους στις 4 εβδομάδες της παρέμβασης, η οποία ωστόσο δεν παρατηρήθηκε στη συνέχεια της μελέτης. Η μελέτη ήταν καλώς ανεκτή χωρίς παρατηρούμενες ανεπιθύμητες επιδράσεις σε όλο το χρονικό διάστημα της μελέτης.
Λατινικά διακείμενα στο πεζογραφικό και δραματουργικό έργο του Κοσμά Πολίτη
Authors: Καγκελάρης Νικόλαος
Published: May 2023

Αντικείμενο της παρούσας διδακτορικής διατριβής είναι η εξέταση των λατινικών διακειμένων στο πεζογραφικό και δραματουργικό έργο του Κοσμά Πολίτη. Βέβαια, στόχος δεν είναι απλώς η συγκρότηση ενός καταλόγου λατινικών διακειμένων, αλλά κυρίως η ερμηνευτική διερεύνηση της λειτουργίας του καθενός από αυτά στα συμφραζόμενα που εντάσσονται, κάτι που είναι καίριας σημασίας, καθώς συμβάλλει στην σφαιρικότερη ερμηνεία των υπερκειμένων, τόσο σε μικροδομικό όσο και (τις περισσότερες φορές) μακροδομικό επίπεδο. Για τη μεθοδολογικά ορθή προσέγγιση του υπό διερεύνηση θέματος κρίθηκε απαραίτητη προϋπόθεση η δομική διάρθρωση της εργασίας σε δύο μέρη, στο πρώτο από τα οποία θα εξεταστούν τα λατινικά διακείμενα πεζογραφικών έργων (Λεμονοδάσος, Εκάτη, «Ελεονόρα», Eroica, Γυρί, Κορομηλιά, Στου Χατζηφράγκου, Τέρμα) του Κοσμά Πολίτη και στο δεύτερο τα λατινικά διακείμενα του θεατρικού του έργου Κωνσταντίνος ο Μέγας. Καθένα από τα δύο μέρη διαρθρώνεται με τη σειρά του σε δύο κεφάλαια. Συγκεκριμένα το πρώτο και το τρίτο κεφάλαιο επικεντρώνονται στα εμφανή λατινικά διακείμενα των πεζογραφικών έργων και του Κωνσταντίνου αντίστοιχα, ενώ το δεύτερο και το τέταρτο στις μνείες και στα λανθάνοντα λατινικά διακείμενα.
Η κοινωνική ιδιότητα του πολίτη στην Ελλάδα
Authors: Σωτηρόπουλος Νικόλαος
Published: May 2023

Η διατριβή συνδέεται άρρηκτα με δύο έννοιες που αποτελούν διαχρονικά αντικείμενα μελέτης και πολύπλευρου ενδιαφέροντος. Από τη μία πλευρά, η κοινωνική ιδιότητα του πολίτη η οποία συνυφαίνει μία πολυδιάστατη έννοια με θεμελιώδη δικαιώματα. Από την άλλη, η μετανάστευση η οποία συνδέει τις ανθρώπινες ανάγκες και αναζητήσεις με τις αντοχές της κοινωνικής αλληλεγγύης αλλά και του κοινωνικού κράτους. Στην αιχμή του δόρατος η Ευρώπη, κοιτίδα ουμανιστικών αξιών και μήτρα δικαιωμάτων, παρά τις ταλαντεύσεις των κρίσεων και τις τάσεις εξατομίκευσης των κοινωνικών δικαιωμάτων. Σκοπός της μελέτης είναι να διερευνηθούν οι πολυσχιδείς δυσχέρειες ενσωμάτωσης των μεταναστών που διαβιούν στη χώρα μας, να αναδειχθούν οι παράγοντες διαμόρφωσης κινδύνων κοινωνικού αποκλεισμού και να διατυπωθούν θέσεις στην κατεύθυνση μείωσης των κινδύνων αυτών αλλά και βελτίωσης των όρων κοινωνικής τους συμμετοχής. Μέσα από την αξιοποίηση των ερευνητικών εργαλείων της συνέντευξης και του ερωτηματολογίου, προέκυψε πως οι μετανάστες που διαμένουν στη Ελλάδα αντιμετωπίζουν σημαντικά προβλήματα εργασιακής ένταξης και διασφάλισης καλών συνθηκών απασχόλησης. Σοβαρά προβλήματα αναδύονται επίσης σε σχέση με τη λειτουργία της δημόσιας διοίκησης, τη γραφειοκρατία αλλά και τη συμπεριφορά των δημοσίων υπαλλήλων, την επικοινωνία και αλληλεπίδραση με τους μεταναστευτικούς φορείς καθώς και με τις ευρύτερες επιπτώσεις της κοινωνικοοικονομικής κρίσης. Κυρίως, οι μετανάστες θεωρούν πως δεν αντιμετωπίζονται ισότιμα με τους Έλληνες, δεν έχουν ίσες ευκαιρίες εργασιακής ένταξης και, κατά συνέπεια, αμφισβητούν την επάρκεια της κρατικής προστασίας στους αδύναμους, τους φτωχούς και τους αποκλεισμένους. Σύμφωνα με τα ευρήματα της εργασίας, επιβάλλεται η αναθεώρηση των κοινωνικών πολιτικών για τη μετανάστευση, αξιοποιώντας τις επιστημονικές έρευνες, αλλά και συνεκτιμώντας τις ιδιαιτερότητες της ελληνικής κοινωνίας. Η κοινωνική ενσωμάτωση διέρχεται από την οδό ενδυνάμωσης των δικαιωμάτων της κοινωνικής ιδιότητας του πολίτη, τα οποία διαμορφώνουν ένα πλέγμα προστασίας πρωτίστως των ευάλωτων κοινωνικών ομάδων, όπως οι μετανάστες.
Αντιλήψεις για την ομάδα εργασίας και γνώσεις-στάσεις των νοσηλευτών Μονάδων Τεχνητού Νεφρού για την πρόληψη μολύνσεων
Authors: Πρεβύζη Ευαγγελία
Published: May 2023

Εισαγωγή: Οι Νοσηλευτές των Μονάδων Αιμοκάθαρσης βρίσκονται αντιμέτωποι με λοιμώξεις, που σχετίζονται με τη νοσηλεία και τις οποίες καλούνται να αντιμετωπίσουν είναι απαραίτητο να αντιμετωπίσουν τις μολύνσεις ως μια «καλά συντονισμένη» ομάδα εργασίας. Σκοπός: Σκοπός της παρούσας μελέτης ήταν να διερευνήσει τις αντιλήψεις για την ομαδική εργασία καθώς και τις γνώσεις-στάσεις των νοσηλευτών των Μονάδων Αιμοκάθαρσης για την πρόληψη των μολύνσεων στην Ελλάδα. Μεθοδολογία: Διεξήχθη συγχρονική έρευνα με δείγμα 1018 Επαγγελματίες Υγείας (ΕΥ) Μονάδων Αιμοκάθαρσης στην Ελλάδα. Τα ερωτηματολόγια που χρησιμοποιήθηκαν ήταν: Ερωτηματολόγιο αντιλήψεων ομαδικής εργασίας (T-TPQ) Εγχειρίδιο TeamSTEPPS®-Instructor και ερωτηματολόγιο ΠΑΡΑΡΤΗΜΑ Α. Αποτελέσματα: Η πλειοψηφία τους ήταν νοσηλευτές (69,45%) και βοηθοί νοσηλευτές (23,87%). Σχετικά με τις αντιλήψεις ομαδικής εργασίας ανά παράγοντα, παρατηρήσαμε ομοιομορφία στις απαντήσεις τους με πολύ υψηλά ποσοστά συμφωνίας καθώς οι μέσες τιμές των σκορ είναι ιδιαίτερα υψηλές 30 – 31 / 35. Οι στάσεις των νοσηλευτών των Μονάδων Αιμοκάθαρσης για την πρόληψη των μολύνσεων διακρίθηκαν σε ιδιαίτερα υψηλά ποσοστά (73,4%) συμμόρφωσης με υψηλή αντίληψη για τον κίνδυνο μετάδοσης μολύνσεων με καλύτερη συμμόρφωση αυτή των γυναικών σε ποσοστό 96,94%. Επίσης, οι γυναίκες φαίνεται να έχουν περισσότερες γνώσεις σχετικά με ασθένειες που επηρεάζουν κυρίως τον παιδιατρικό πληθυσμό. Αναλυτικότερα για την ιλαρά (59% vs 45,86%, p=0,006), την παρωτίτιδα (51,04% vs 42,11%, p=0,062) και την ερυθρά (51,65% vs 39,10%, p=0,009) οι γυναίκες είχαν υψηλότερα ποσοστά ορθής γνώσης μετάδοσης από τον ασθενή στο νοσηλευτή. Φάνηκε ότι το επίπεδο γνώσης μεταξύ των δύο φύλων δεν διέφερε σχετικά με τον HBV (63,16% vs 66,71%, p=0,430), τον HCV (63,91% vs 66,71%, p=0,553), τη μόλυνση από HIV (78,95% vs 81,76%, p. =0,471) και γρίπη (55,64% έναντι 59,61%, p=0,394). Συμπεράσματα: Η μελέτη αυτή ανέδειξε για πρώτη φορά το υψηλό επίπεδο αντιλήψεων για την ομαδική εργασία των νοσηλευτών των Μονάδων Αιμοκάθαρσης στην Ελλάδα. Συνιστάται η διερεύνηση της ορθής εφαρμογής των μέτρων πρόληψης και η ανίχνευση των αιτιών απόκλισης από τις καλές πρακτικές με επακόλουθες έρευνες σε Μονάδες Αιμοκάθαρσης της Ελλάδας. Λέξεις κλειδιά: Aντιλήψεις, γνώση, μόλυνση, μονάδα αιμοκάθαρσης, νοσηλευτές, ομαδική εργασία, πρόληψη, στάσεις.
Ισλαμικό κράτος Ιράκ και Συρίας (ISIS)
Authors: Αντωνίου Κωνσταντίνος
Published: May 2023

Στη συγκεκριμένη εργασία δόθηκε ιδιαίτερη έμφαση στην πολιτική θεωρία καιεπιστήμη με στόχο να κατανοηθεί πληρέστερα η φιλοσοφική προσέγγιση τηςθεματικής μας. Έτσι το γεγονός ότι εκτενή μέρη διατριβής αναφέρονται στην πολιτική επιστήμη, οφείλεται στην θέση μας ότι, προκειμένου να γίνουν κατανοητές κάποιες ουσιώδεις παράμετροι της τρομοκρατίας του Ισλαμικού Κράτους και της κατάστασης που επικρατούσε καθ’ όλη τη διάρκεια της δράσης του στη Μέση Ανατολή και κατά τη διάρκεια των αιματηρών επιθέσεών του στην Ευρώπη (και όχι μόνο), είναι απαραίτητο να δοθεί η απαραίτητη προσοχή τόσο στην καταγραφή των συμβάντων όσο και στην ερμηνευτική τους προσέγγιση εκ μέρους των πολιτικών επιστημόνων.Με άλλα λόγια, θεωρήσαμε ότι, για να μιλήσουμε για την πολιτική θεωρία του Σμιτ,για την έννοια του ολοκληρωτισμού στην Χάνα Άρεντ, αλλά και για την προσέγγισητων τρομοκρατικών επιθέσεων στη Γαλλία ως «φασιστικών εγκλημάτων» μέσα από τηφιλοσοφική ανάλυση του Αλαίν Μπαντιού, έπρεπε πρώτα να αναφερθούμε σε θεωρίεςτης πολιτικής επιστήμης όπως ήταν χαρακτηριστικά η θεωρία των τεσσάρων κυμάτωντου Ντέιβιντ Ράποπορτ (David Rapoport) και η θεωρία του πέμπτου κύματος του ΠίτερΝόιμαν (Peter Neumann).
Historias de las epidemias en América Latina. Reflexiones para pensar el presente
Authors: Pohl Valero Stefan , Zárate María Soledad
Published: May 2023

Desde los primeros casos reportados de contagios de COVID-19 en América Latina, durante marzo de 2020, las consecuencias de la epidemia han concentrado el interés de columnas e investigaciones periodísticas y científicas, y también han inspirado el diseño de políticas sanitarias y sociales para, respectivamente, contener la pandemia y aminorar sus devastadores efectos en la salud y la economía de la población. Cuando comenzamos a pensar este dosier, una de las discusiones que emergió fue la forma como el COVID-19 se ha convertido en un recordatorio de que las epidemias, a pesar de los avances biomédicos, siguen siendo uno de los grandes desafíos para la ciencia, la política y la economía y, en última instancia, para la preservación de la humanidad. Se nos hizo evidente que estábamos contemplando un desgarrador ejemplo, a la vista de todos, del mensaje central del campo de los estudios sociales de la salud: que los procesos de salud y enfermedad son el resultado de un andamiaje biológico, social y cultural que articula significados, entornos, representaciones y estructuras económicas y de poder particulares.
Editorial
Authors: Calderón Ortiz Bertha
Published: May 2023

Desde el inicio de la década de 1960 Stanley Hall, quien fue un psicólogo inglés, fue la primera persona que habló de la adolescencia como una etapa que debería ser vista de una manera diferencial. Sin embargo, para algunos antropólogos la adolescencia es un fenómeno más de nuestra cultura, dado que hay algunas culturas para las que ni siquiera existe un término que los defina. De ahí que tomaron gran importancia y auge el entender, diagnosticar, tratar y rehabilitar las condiciones tanto físicas como psíquicas y biológicas, además de los comportamientos que presentan los adolescentes en la sociedad moderna. Los cambios sociales, culturales y de diversas índoles a los que se han visto enfrentados, en especial en los dos últimos años a raíz de la pandemia mundial, hace que debamos atender de manera especial a este grupo etario.