bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigação qualitativa da presença de lacase em fungos de podridão branca
Authors: Silva Nadine Guimarães da , Lopes Eraldo Ferreira , Cavallazzi José Renato Pereira
Published: December 2023

Introdução: Nos últimos anos, tem havido significativo aumento no nível de compostos xenobióticos presentes em corpos hídricos e o setor têxtil merece destaque, por ser o principal responsável pelo aumento dos efluentes carregados, principalmente, com corantes. Fungos de podridão branca são microrganismos degradadores naturais, que atuam sobre compostos recalcitrantes como a lignina, presente em troncos de árvores e que possuem longas cadeias orgânicas. Esta capacidade se dá pelo fato sintetizarem enzimas que atuam nestas moléculas, como a lacase. Uma vez que a estrutura molecular de alguns corantes é semelhante à da lignina, a ciência tenta fazer uso desses microrganismos para a biorremediação destes compostos. Objetivo: O objetivo do presente estudo é investigar de forma qualitativa a presença de lacase em um fungo de podridão branca isolado no Campus da UFAM, em Manaus. Metodologia: O isolado foi repicado em 3 placas de Pétri contendo meio batata dextrose ágar, acrescido ácido tânico (5g/L) e 3 placas de Pétri contendo BDA acrescido com guaiacol (500 ppm), seguido de incubação em temperatura ambiente. Resultados: Após 5 dias de cultivo, observou-se um halo marrom ao redor da colônia acrescida com ácido tânico e um halo vermelho ao redor da colônia acrescida com guaiacol. Conclusão: O aparecimento dos halos indicou a presença da oxidação pela lacase, demonstrando que o fungo sintetiza esta enzima.
Teste de sensibilidade de solventes utilizados na diluição de extratos vegetais com potencial antimicrobiano sobre staphylococcus epidermidis
Authors: Silva Sharleane Souza da , Pereira Mateus da Silva , Chamy Michel Nasser Corrêa Lima
Published: December 2023

Dentre os desafios encontrados nas pesquisas voltadas para estudo da atividade antimicrobiana de extratos vegetais, pode-se destacar a dificuldade em encontrar soluções que possam diluir os extratos vegetais com eficiência sem apresentar toxicidade celular frente aos organismos testados. Objetivo: Avaliar a atividade antimicrobiana de solventes utilizados na química de produtos naturais frente a bactéria Staphylococcus epidermidis. Metodologia: Foram selecionados 10 soluções amplamente utilizadas para diluir extratos vegetais em teste bactericidas ou bacteriostáticos: Água destilada; Álcool (50%, 70%, 92%); Hexano P.A.; Tween (20 e 80) e DMSO (1%, 50%, P.A.). O ensaio foi desenvolvido de acordo com o método disco-difusão, onde os discos de papel filtro de 6 mm estéril foram embebecidos com as soluções selecionados, em seguida os mesmo foram submetido a secagem em temperatura ambiente por 20 minutos e posteriormente posicionados em placa de Petri com meio  Mueller Hinton Ágar cultivado com a bactéria  Staphylococcus epidermidi. O antibiótico Clorafenicol (30,0 µg) foi usado como controle. Ademais, as placas foram incubadas em estufa B.O.D a 37°C por 24 horas. O surgimento de halos de inibição foi verificado. Resultados: O antimicrobiano (controle), as soluções DMSO P.A. e TWEEN 20 apresentaram halo de inibição. Conclusões: Seguindo o procedimento de secagem em temperatura ambiente, com exceção do DMSO P.A. e TWEEN 20, as demais soluções testadas apresentaram possibilidade de crescimento microbianos nas concentrações testadas.
Biotecnologia azul: explorando e preservando os tesouros dos oceanos
Authors: Souza Aylanara Mendes de , Malosso Milena Gaion
Published: December 2023

A biotecnologia azul é uma área empolgante e em expansão que concentra seus esforços na aplicação de princípios biológicos para explorar os vastos ecossistemas marinhos e promover a sustentabilidade dos oceanos. Esta área, representada pela cor azul, simboliza a profunda conexão entre a biotecnologia e o ambiente marinho.Uma das aplicações mais significativas da biotecnologia azul envolve a bioprospecção, que é a busca por organismos marinhos com propriedades biológicas únicas que podem ser utilizadas para desenvolver novos medicamentos, produtos químicos e materiais. Os oceanos são um tesouro de biodiversidade, abrigando uma infinidade de organismos ainda desconhecidos que podem conter segredos valiosos para a medicina e a indústria.Além disso, a biotecnologia azul desempenha um papel fundamental na aquicultura, onde é utilizada para melhorar a produção de frutos do mar, tornando-a mais eficiente e sustentável. A engenharia genética também é aplicada para desenvolver espécies de peixes resistentes a doenças e mais adaptadas às condições de cultivo.Outro aspecto importante é a conservação marinha. A biotecnologia azul contribui para a preservação de espécies ameaçadas de extinção, monitorando a saúde dos recifes de coral e dos ecossistemas oceânicos e desenvolvendo métodos de restauração ecológica. Enfim, a biotecnologia azul desempenha um papel vital na pesquisa, exploração e preservação dos oceanos. Ela ilustra como a aplicação de técnicas biotecnológicas avançadas pode ajudar a desvendar os segredos dos ecossistemas marinhos e promover a sustentabilidade dos recursos oceânicos, essenciais para a saúde do nosso planeta.
Análise da matriz dafo no sistema de monitoramento RFID no posto de fiscalização da Suframa
Authors: Marques Ricardo Jander Cardoso , Barbosa Edilson Pinto , Bichara Julimar da Silva
Published: December 2023

A movimentação em posto de fiscalização e terminais portuários desenvolve-se a cada ano e com este desenvolvimento, é importante utilizar tecnologias que podem diminuir o tempo gasto em circunstâncias adversas, tais como, encontrar e verificar um material/contêiner dentro do terminal portuário de forma rápida e produtiva. Este sistema pode ser executado com a tecnologia RFID (Radio Frequency Identification), que utiliza radiofrequência para captar as informações enviadas pelos transmissores, decodificando e transmitindo essas informações para o software, o que permite a verificação em tempo real. Utilizou-se a metodologia de investigação qualitativa bem como uma revisão bibliográfica, empregando o método de gestão DAFO (em Inglês, SWOT, Strengths, Weaknesses, Opportunities e Threats), sigla para Debilidades, Ameaças, Fortalezas e Oportunidades, a fim de identificar as variáveis internas (fortalezas e debilidades) e as variáveis externas (ameaças e oportunidades). É uma ferramenta de análise de gestão que funciona fazendo uma coleta de dados, assim encontrando: debilidades, aquilo que prejudica a empresa; fortalezas que são características positivas que serão mantidas e aprimoradas no caso das empresas que operam movimentação em terminais portuários ou postos de fiscalização, e tem origem interna, ou seja, da própria organização; ameaças, que são fatores externos que no futuro comprometerão as suas atividades; e por fim, as oportunidades, que são todas as possibilidades externas que possibilitarão o avanço e criação de alicerces que possibilitem a afirmação e expansão da empresa no mercado, como a inovação. A partir da matriz DAFO, o que se pôde observar foi que mesmo diante de debilidades e ameaças o sistema RFID é uma tecnologia bastante promissora para as empresas tendo em vista que esses pontos negativos podem ser corrigidos e neutralizados.
Propriedade intelectual como instrumento estratégico para o desenvolvimento industrial e tecnológico e o potencial de uso da propriedade intelectual para a estratégia competitiva das empresas
Authors: Barbosa Edilson Pinto
Published: December 2023

Propriedade Intelectual é o conjunto de direitos que incidem sobre as concepções da inteligência. Capital Intelectual é a soma de conhecimentos de todos em uma organização, sendo o principal responsável pela vantagem competitiva da mesma. Ativos intangíveis são os que não possuem existência física e são baseados em conhecimento, como exemplo: direitos exclusivos de comercialização, direitos autorais, cultivares, marcas, patentes, registros de software, design, indicações geográficas, segredos de negócio, etc. O objetivo deste trabalho e analisar a Propriedade Intelectual como instrumento estratégico para o desenvolvimento industrial e tecnológico e o potencial de uso da Propriedade Intelectual para a estratégia competitiva das empresas. Utilizou-se a metodologia de investigação qualitativa bem como uma revisão bibliográfica, empregando a pesquisa Sondagem Industrial realizada pela CNI em 600 empresas, divulgadas em 14 de maio de 2002, que revelou pouco importante a propriedade intelectual e a absorção de pesquisadores em seus quadros funcionais”. A importância dos Ativos Intangíveis, segundo estudo conjunto feito pelo Citibank e a empresa de consultoria Interbrand, as maiores empresas do mundo concentravam grande parte de seu capital no Ativos Intangíveis: IBM - 89% do seu valor patrimonial (US$ 172,8 bilhões); COCA-COLA - 95% do seu valor patrimonial; KELLOGS - 94% do seu valor patrimonial; AMERICAN EXPRESS - 81% do seu valor patrimonial; MICROSOFT o valor dos ativos intangíveis é 12 vezes maior do que o dos ativos tangíveis; BANESPA - 85% do valor pago pelo Banco Santander, representando US$ 3,0 bilhões. A relação das Exportações americanas e Propriedade Intelectual, em décadas anteriores foram as seguintes: em 1947, menos de 10% das exportações eram cobertas por proteção de propriedade intelectual, em 1986, essa participação havia crescido para 37% e em 1994, mais de 50% das exportações americanas possuíam conexão com direitos de Propriedade Intelectual. A agregação de valor em produtos nos setores da economia e seus valores (em US$ /Kilo) são: 0,30 Agrícola, 10,00 Automotivo, 100,00 Eletrônico (Áudio e Vídeo), 200,00 Defesa (foguetes), 1.000,00 Aeronáutico Comercial, 2.000,00 Defesa (mísseis) e Telefonia celular, 2.000,00 a 8.000,00 Aeronáutico militar e 50.000,00 Espacial (Satélites). Portanto, o uso de Propriedade Intelectual através da proteção do intangível é uma estratégia para geração de negócios por empresas inovadoras.
Biotecnologia vermelha: inovação médica e terapêutica
Authors: Alves Akyla Anara Frota Lima , Malosso Milena Gaion
Published: December 2023

A biotecnologia vermelha é um segmento vital da biotecnologia que se concentra na aplicação de avanços científicos e tecnológicos para resolver problemas médicos e melhorar a saúde humana. Esta área dinâmica engloba uma ampla gama de aplicações, desde o desenvolvimento de medicamentos inovadores até terapias genéticas revolucionárias, com o objetivo final de aliviar o sofrimento humano e prolongar a vida. Um dos aspectos mais proeminentes da aplicação biotecnológica à saúde é a pesquisa e o desenvolvimento de novos medicamentos. Isso inclui a identificação de alvos terapêuticos, a síntese de moléculas farmacêuticas e a realização de ensaios clínicos rigorosos para garantir a segurança e eficácia dos tratamentos. Muitos medicamentos que salvam vidas, como vacinas e terapias para doenças crônicas, foram desenvolvidos por meio da biotecnologia vermelha. Além disso, a terapia genética é uma área em crescimento na biotecnologia vermelha. Ela envolve a modificação de genes defeituosos para tratar doenças genéticas raras e complexas. As terapias genéticas oferecem a promessa de cura para condições antes consideradas incuráveis. A biotecnologia vermelha também está intimamente relacionada à pesquisa médica, ao diagnóstico molecular e à medicina personalizada. Esses avanços têm o potencial de revolucionar a maneira como abordamos a saúde, tornando os tratamentos mais eficazes e direcionados às necessidades individuais. Por fim a biotecnologia vermelha desempenha um papel fundamental na melhoria da saúde humana. Seja na criação de novos medicamentos, no desenvolvimento de terapias inovadoras ou na pesquisa médica de ponta, essa área continua a moldar o futuro da medicina e da biotecnologia de maneira impactante.
Vacinação: o que é imunidade de rebanho e por que devemos nos vacinar
Authors: Souza Aylanara Mendes de , Alves Wendrio Nunes , Faria Carolina Arruda de
Published: December 2023

Introdução: A vacinação é um tema de extrema importância na área da saúde, pois se trata de uma estratégia eficaz para prevenir o avanço de doenças infecciosas e proteger a população. Através da administração de vacinas, é possível estimular o sistema imunológico a produzir uma resposta imune específica contra determinados patógenos, conferindo imunidade e reduzindo a incidência de doenças. Objetivo: entender, com base na literatura científica, o que é imunidade de rebanho e porque é importante a vacinação. Método: Foram utilizados artigos científicos, livros e documentos oficiais relacionados ao tema da vacinação. A busca foi feita em bases de dados como Scopus, Scielo e Google Acadêmico. Resultados: da pesquisa revelaram inúmeros artigos relacionados à vacinação, demonstrando a relevância e o interesse científico sobre o assunto. Foram encontrados estudos que abordam diferentes aspectos da vacinação, como eficácia, segurança, cobertura vacinal e impacto na saúde pública. Conclusão: A vacinação é uma estratégia fundamental para a prevenção de doenças infecciosas e a promoção da saúde. Por meio da imunidade de rebanho, atingida quando uma porcentagem suficiente da população é vacinada, é possível controlar e até mesmo erradicar doenças, como foi o caso da varíola. Essa porcentagem varia de acordo com a doença e população. Assim, a vacinação contribui para a redução da morbidade e mortalidade, melhorando a qualidade de vida.
Biotecnologia verde
Authors: Figueira Lavinia Evellyn Peres , Malosso Milena Gaion
Published: December 2023

A Biotecnologia de cor verde geralmente se refere a abordagens ecologicamente sustentáveis e referentes ao meio ambiente, bem como ao estudo voltado a biotecnologia relacionada a plantas. Essa divisão de cor verde da biotecnologia está relacionada ao uso de plantas para práticas que visam minimizar o impacto ambiental, tais como a produção de produtos biodegradáveis, sem danificar o meio ambiente. O uso de plantas geneticamente modificadas também pode resolver problemas ambientais, promovendo a conservação e preservação da natureza. É de suma importância para os seres humanos, pois as culturas que utilizam sementes geneticamente engenheiradas apresentam características agronomicamente importantes, tais como maior potencial nutritivo, resistências a pragas, doenças e alterações climáticas, além de apresentar características agronômicas de interesse econômico. A biotecnologia verde busca soluções que se alinhem com a preservação do meio ambiente e a sustentabilidade a longo prazo, bem como vantagens ambientais, ecológicas, sociais e econômicas para o mundo.
Buying And Selling Orders In The Kitab Al-Jami' Sahih Muslim: A Study Of Takhrij
Authors: Syaichoni Ahmad
Published: December 2023

Kitab Al-Jami', better known as Kitab Sahih Muslim, is a famous kutub al-sittah. This book is attributed to Al-Imam Abu al-Husain Muslim ibn al-Hajjaj al-Qusyairi al-Naisaburi, better known as  Imam Muslim. This book discusses hadiths in various spheres of life, such as aqidah, worship, and muamalah. This paper traces the muamalah's study of buying and selling orders in the Muslim Sahih Book. One transaction that has developed along with the advancement of information and technology is buying and selling orders, known as bay' al-salam. Bay al-salam transactions in the modern era are used in online buying and selling transactions. This paper seeks to trace how the position of buying and selling greetings in the hadith of the Prophet is contained in the Book of Sahih Muslim.  This paper uses literature research using the takhrij hadith method. The takhrij hadith method is used with a thematic approach (maudhu'i). The results showed that the hadith about buying and selling orders is in the hadith 'aziz with muttasil. The matan of this hadith does not contradict the intellect and postulates of the Qur'an. Order buying and selling transactions in their actualization experience differences in criteria applied in Islamic bank financing products and online buying and selling or e-commerce.  Greeting transactions are not only in agriculture but also include various products with a cash payment system at the beginning of the transaction.
Mustafā Al-Sibā’ī And His Perspectives About The Authority Of Aḥad Ḥadīth Based On His Book Al-Sunnah Wa-Makānatuhā Fī Al-Tashrī’ Al-Islāmī
Authors: Binti Abdul Rahim Zati Nazifah
Published: December 2023

The authority of Prophetic narrations definitely have been one of the most central problem discussed among scholars, even for mutawātir ḥadīth, not to mention aḥad ḥadīth which not fulfil the requirments to be considered as mutawātir. This study mainly discussing about the authority of aḥad ḥadīth based on perspectives from Mustafā Al-Sibā’ī, a prominent figure of Islamic scholars in one of his well-known book, Al-Sunnah wa-Makānatuhā fī Al-Tashrī’ Al-Islāmī. This book mainly written to rebut lies and arguments from the enemies of Sunnah. Hence this study seeks to analyse views, opinions and discussions regarding aḥad ḥadīth which mostly pointed out by Al-Sibā’ī in order to refute arguments from enemies of Sunnah, or to be exact, from those who reject the validity of aḥad ḥadīth. Thus, by using descriptive-analytical method, this article will firstly provide brief descriptions about Mustafā Al-Sibā’ī and his book before discussing throughout his writing about aḥad ḥadīth. The result of this study hopefully may clears any misunderstanding created by Sunnah’s enemies regarding aḥad ḥadīth.
Orientalists' Criticism Of Saida Aisha's Marriage: Analytical Study Of Hadith Narrations
Authors: Kamruzzaman Md. , Obeid Abdulrahman Hussein
Published: December 2023

This Article presenting the divergent orientalists’ opinions, that were not indicated in most cases by reliable historical texts, about the ages of Saida Aisha when she got married to the Prophet. They have noticed the scarcity of information about the childhood of Saida Aisha and if her childhood was shrouded in mystery, then how could it be possible to confirm her early marriage. This research adapted the descriptive approach by collecting contradicted evidence of debaters and analyzing them in the light of Hadiths data related to the subject. The researchers concluded that reconsidering the age of Saida Aisha is necessary since the clear indications to her age in al-Bukhari and other canonical books of prophetic traditions are not prophetic statements but historical records of the companions and individual matters. Her sister Asma’ was 10 years older, and she was 27 years when they migrated to Yathrib which means Saida Aisha was 17 when they migrated! According to this historical account the age of Saida Aisha when got married was around nineteen.
Manhaj Ta‘lil Percanggahan Riwayat Hadis Oleh Ibn Hazm Al-Andalusiy Dalam Al-Muhalla
Authors: Halim Syimir Asyraaf Eddie , Shamsudin Roshimah
Published: December 2023

Ibn Hazm al-Andalusiy was an eminent Muslim scholar. Nevertheless, he was not free of criticism. Among the criticisms levelled at him was that he had not determined the defects (ta‘lil) for many conflicting hadis narrations like most other hadis scholars had. Thus, this paper aims to analyse his ta‘lil methods (manhaj) for contradicting hadis narrations in his work, al-Muhalla. This qualitative research is carried out using the literature review method. The data obtained was then analysed based on inductive and deductive methods. The findings of the study show that some of Ibn Hazm's methods to determine the defects in conflicting hadis narrations are in line with most hadis scholars, such as rejecting the element of insertion (idraj) in the text of hadis and refraining (tawaqquf) from making decisions for narrations containing discrepancies (idtirab). On the other hand, some of his methods in this matter were found to be in contradiction with the views of the majority of hadis scholars, such as rejecting allegations that reliable (thiqah) narrators could make mistakes and accepting additions (ziyadah) from credible narrators. This shows that he had his own method for determining the defects in conflicting hadis narrations.
Integrasi Al-Quran Dan Sunnah Nabawi Dalam Membentuk Keluarga Madani: Panduan Ibu Bapa Ketika Berkomunikasi Dengan Anak Perempuan
Authors: Saidin Maisarah , Shamsudin Roshimah
Published: December 2023

Parents have a significant responsibility to shape their children in accordance with Islamic teachings. As is known, prior to the advent of Islam, the pre-Islamic Arab society mistreated women and daughters. However, with the arrival of Islam brought by Prophet Muhammad (peace be upon him), their dignity was elevated to a higher level. Daughters symbolise the future generation because they will become mothers and contribute to the quality of the next generation. Therefore, if daughters do not receive the best education and upbringing, they may not be able to handle their responsibilities as mothers to their own children. Education grounded in positive values can shape outstanding individuals. Hence, this study aims to analyse the Quranic and Prophetic approaches to shaping a Madani family through ethical communication with daughters. This is a qualitative study that employs data collection methods, with data being analysed through inductive and deductive methods based on the content of Quranic verses and their interpretations, as well as the core Hadith texts like the Al-Kutub Al-Sittah. The study findings suggest that an approach characterised by love and attention to children, firmness with wise disciplinary measures, and consistent guidance on religious values should serve as a guide for parents in communicating with their daughters.
Scholarly Views And Analysis On Forged Hadith About Rajab Sunnah Prayers
Authors: Ibrahim Norhasnira
Published: December 2023

Rajab is a sacred month in the Islamic calendar that is historically and religiously significant. Muslims regard this month as an opportunity to engage in increased worship, repentance, and preparation for the upcoming Ramadan. There are numerous hadiths about supplementary deeds to be practiced in the month of Rajab. However, some of them are reported as forged hadiths and need to be clarified to our community. Therefore, the objectives of this paperwork are to identify forged hadith focusing on performing sunnah prayers in Rajab and to analyse the chain of narrators and hadith status based on hadith scholars’ reports. This study applies the qualitative method based on library research by collecting data from books, paper works, and websites related to the study. Next, the content analysis method is used to analyse the evaluation and views of hadith scholars by referring to the collection of forged hadith books written by Ibn al-Jawzi, al-Suyuti, al-Shawkani, and Ibn ‘Iraq. The finding shows that there are five topics of forged hadiths related to sunnah prayers in Rajab which are sunnah prayer at the beginning of Rajab, sunnah prayer during the month of Rajab, al-Ragha’ib prayer, Nisf Rajab prayer, and Isra’ Mi’raj prayer.
تطبيقات السنة النبوية في المعاملات المالية
Authors: Saleh Abdulmajid Obaid Hasan , Alkatiri Ahmad Fathi
Published: December 2023

This research examines the applications of the Prophetic tradition (Sunnah) in financial transactions and aims to analyze and evaluate the implementation of the Prophetic tradition in financial transactions by studying the Prophetic evidence and its legal interpretations, elucidating how Muslims should conduct themselves responsibly and correctly in the field of financial and economic matters in accordance with the Prophetic tradition. The significance of this research lies in providing a legal guideline for Islamic financial institutions and individuals to execute their transactions in a manner that aligns with the Prophetic tradition. Utilizing a descriptive and analytical approach grounded in Prophetic Hadiths, recognized Islamic texts, and jurisprudential sources, a diverse range of financial transactions were studied. The results indicate that financial exchange between banks can be permissible if conducted without interest and adhering to Shariah regulations. The Mudarabah contract is also considered permissible and feasible in financial transactions, provided it complies with Shariah regulations. However, trading in commercial papers involving interest is considered impermissible. In addition, bank deposits and current accounts are considered Shariah-compliant when adhering to Shariah regulations. Covered documentary credits are considered permissible, contingent on adherence to appropriate Shariah conditions. Furthermore, the Salam contract is emphasized as a legitimate means of financing seasonal agricultural production. Lastly, it is stressed that penalty clauses in non-debt financial contracts are permissible for compensating damages, provided they are not tied to usurious interest. These findings provide valuable insights into how financial and banking transactions can be organized in accordance with the Prophetic tradition and Islamic values, contributing to enhancing compliance with Shariah regulations in the financial and banking sector and promoting trust and transparency in this context.
التقمص العاطفي وتطبيقاته في السنة النبوية
Authors: Mohd Redzwan Ili Dalila Binti , Bannga Ahmed El-Mogtaba
Published: December 2023

Empathy is one of the components of emotional intelligence and it is defined as the ability to perceive what other is experiencing whether it is emotionally or cognitively. It is said that during the age of social media, the ability of people to empathize with others has dwindled as the consequence of the role played by algorithms in creating what is known as the “filter bubbles” that skew or limit the information an individual user sees on the internet based on the searches. This study aims to lay down the Islamic foundation in the subject matter of empathy and to address its application in the Prophetic tradition. The research adopts inductive and analytical approaches in presenting the discussion regarding the application of empathy and important addition rendered by the Prophetic tradition in the subject. Some of the findings of the research lies in several observations; the empathic capacities which are innate in human being originated from Allah and that He is the source of compassion and mercy; there are abundant of aḥadīth that encourage us to take the perspective of others as perspective-taking is one of the essential components in empathy: and empathy is the mechanism of altruism and helping behaviour while also instigating other good characters and traits in human being.
Motivos para la práctica de actividad física en adolescentes en función de la edad y género de la ciudad de Cuenca-Ecuador
Authors: Tola Gutiérrez Andrés Bolívar , Torres Palchisaca Zoila Guillermina
Published: December 2023

Introducción: En la actualidad existe una gran cantidad de adolescentes que no realiza Actividad Física (AF), debido a diferentes circunstancias, pero al mismo tiempo existen factores que promueven que adquieran hábitos saludables como el ejercicio regular. Objetivo: El objetivo del estudio fue determinar la determinar los motivos para la práctica de AF en adolescentes en función de la edad y género de la ciudad de Cuenca – Ecuador. Metodología: Se realizó una investigación no experimental, de tipo descriptivo con un alcance transversal, con una muestra de 135 adolescentes (50 mujeres 85 hombres) de un colegio particular, entre los 13 y 17 años (14.63 ±1.3). Para determinar los motivos de la práctica de AF se utilizó el Autoinforme de Motivos para la Práctica de Ejercicio Físico (AMPEF), en el que se realizó un análisis descriptivo y correlacional de las once categorías a través del estadístico Chi Cuadrado de Pearson, mediante el programa SPSS versión 25.0. Resultados: valores medios altos en la categoría Prevención y Salud Positiva tanto en hombres como en mujeres y valores bajos en la categoría Urgencias de Salud para el género masculino y Competencia en el femenino; así también relaciones entre la categoría Competencia-Género, y Fuerza y Resistencia Muscular-Edad. Conclusiones: Determinando que existen ligeras diferencias entre los motivos de la práctica de AF entre hombres y mujeres, al igual que en los rangos de edad, debido principalmente a los cambios en el desarrollo físico y cognitivo de los adolescentes. Área de estudio general: Cultura Física. Área de estudio específica: Actividad Física.
Nivel de actividad física y su relación con la satisfacción corporal e índice de masa corporal en adolescentes
Authors: Casierra Cárdenaz Martín Vicente , Torres Palchisaca Zoila Guillermina
Published: December 2023

Introducción: La actividad física es un aspecto importante en la vida de una persona, puesto que contribuye con el fortalecimiento de su salud y disminuye el riesgo de padecer enfermedades a largo plazo. Objetivo: Analizar la relación entre el nivel de actividad física con la satisfacción corporal e índice de masa corporal en adolescentes. Metodología: Es un estudio descriptivo, transversal, empírico con enfoque cuantitativo. La muestra estuvo conformada por 196 adolescentes pertenecientes al segundo año de bachillerato. Los instrumentos aplicados fueron el Cuestionario Internacional de Actividad física, el Body Shape Questionnarie-14 y la fórmula establecida por la OMS para el cálculo del índice de masa corporal. Resultados: Se determinó que el nivel más alto de actividad física corresponde al género masculino con una media de actividad física vigorosa de 1630 MET, mientras que las mujeres se ubican en 709 MET. Respecto al índice de masa corporal, la mayoría de estudiantes se encuentran en nivel normal, sin embargo, existe un valor importante en cuanto al nivel de obesidad en estudiantes de 17 años. Conclusión: Existe una relación directa entre el nivel de actividad física e índice de masa corporal en adolescentes, esto se debe al nivel de actividad física bajo, dando como resultado la presencia de índices de masa corporal altos y bajos que confluyen en la aparición de casos de sobrepeso, obesidad, desnutrición moderada y severa.
The Effect of Cooperative Learning Approach, Competitive and Physical Fitness on Basketball Dribble Skills
Authors: Wijaya Kusuma I Ketut Hendry
Published: December 2023

The condition of learning basketball games in physical education in junior high schools (SMP) is still not optimally carried out in the implementation of the teaching and learning process, especially in the context of developing learning outcomes of basketball skills. The method used in this research is an experimental method with Anava 2 x 2 design. The population in this study were seventh grade students of SMP Negeri 2 Sawan as many as 78 students. The sampling technique uses the Verducci technique, to be as many as 78 people according to what is needed in the study.The instrument chosen by the author is the physical fitness test from AAHPERD for the junior high level and for basketball dribbling skills with a validity level of 0.89, namely the dribble test from Horrison. The author's hypothesis in this study is (1) The learning outcomes of students' basketball skills taught through the Cooperative learning approach are better than the Competitive learning approach as a whole. (2) There is an interaction between learning approaches and physical fitness on learning outcomes of basketball skills. (3) The learning outcomes of basketball skills of student groups taught through the Competitive learning approach are better than those of student groups taught through the Cooperative learning approach in groups of students who have high fitness. (4) The learning outcomes of basketball skills of student groups taught through the Cooperative learning approach are better than those of student groups taught through the Competitive learning approach in groups of students who have low fitness.
Application of Augmented Reality Based Freestyle Swimming Material Learning Media for Junior High School Students
Authors: Feri Apriani  , Rahma Devi  , Nurkadri
Published: December 2023

This study aims to develop and apply learning media for freestyle swimming material based on augmented reality to junior high school students in the city of Padang Sidempuan. The type of research in this study is qualitative research with development studies used in a research must be based on the issues raised. The research procedure used in this study is in accordance with the steps for using the method Research and Development. The sample used in this study was PJOK teachers in Padang Sidempuan District. The results of this study indicate that out of 10 small group trial samples with a total score of 650 divided by a maximum score of 700 x 100%, it produces a presentation of 92.8% with the following criteria:Very Worth it.The results of the stage 2 trial on teachers are outlined through the formula for the percentage of the number of answers/maximum score x 100% with the following results. Of the 20 samples of the Phase II trial with a total score of 1.505 divided by a maximum score of 1.600 x 100% yield presentation of 94.0% with criteriaVery Worth it.The conclusion in this study is eligibility based learning media augmented reality Freestyle swimming material for PJOK teachers declared appropriate and can be used for PJOK teachers in using media-based learning augmented reality freestyle swimming material.
Application of Vagal-Mediated Heart Rate Variability and Subjective Markers to Optimise Training Prescription: An Olympic Athlete Case Report
Authors: Chiron François , Bennett Samuek , Thomas Claire , Hanon Christine , Léger Damien , Lopes Philippe
Published: December 2023

Abstract
Purpose: The aim of this case study was to investigate whether the variation in parasympathetic branch activity, in conjunction with subjective data, could optimize the training prescription for an elite athlete during an Olympic season. Methods: During the preparatory phase for the Tokyo Olympic Games, a world-class female 3000m steeplechase runner (Age: 20 years, Height: 168 cm, Weight: 52 kg, VO2max: 67.1 mL⋅min⋅kg-1) recorded Heart Rate Variability (HRV), conducted orthostatic tests, and completed subjective evaluations four times a week throughout the different training periods that constitute a pre-Olympic season. The Pearson correlation coefficient and the Shapiro-Wilk test, along with paired T-tests, were used to assess correlations and compare mean differences between variables concerning baseline measurements and each of the other training periods. Results: The natural logarithm of the root mean square of the standard deviation during supine measurement (LnRMSSDsu) exhibited a significant negative correlation with the training load based on Rating of Perceived Exertion (RPE) and sleep quality (P < 0.05). Heart rate during supine measurement (HRsu) showed a significant positive correlation with subjective perceived exertion, sleep quality, stress, muscle soreness, and fatigue (P < 0.01). Compared to the baseline (rest), LnRMSSDsu, HRsu, RPE, and sleep quality were significantly different during the training, camp, and altitude training camp periods. Conversely, markers of standing Heart Rate Variability (HRV) did not differ during competition periods. Conclusion: Standing Heart Rate Variability, when combined with subjective markers, serves as a relevant monitoring tool for adapting training periods to regulate psychophysiological effects.
IIncentives and Their Role in the Job Performance of the Sports Federations in Kirkuk from the Point of View of Sports Federations Members
Authors: Saber Mohammed , Omar Zaki , Qader Barzan
Published: December 2023

This study aims to determine the relationship between incentive, job performance levels and job performance among the members of sports federations in Kirkuk. The universe and the sample of the study were chosen with the intentional method consisting of (60) members of sports federations in Kirkuk. The researcher distributed (50) questionnaires to the study sample, then took a sample of (10) from the original community for the pilot study,the researcher used the survey method from the basic methods in the descriptive research because it is suitable for the nature of the study. According to our findings; The reward and financial incentive provided by the federation, moral appreciation was found to be an additional incentive to do more tasks (2.68±0.62 ; 2.60±0.60). On the other hand; It was determined that the participants preferred to receive financial incentives compared to moral incentives (3.98±0.55). Regarding the work performance of its members; It was determined that the positive performance evaluation results motivated me and pushed me to work efficiently (2.72±0.64), while the members obeyed the working rules and procedures (3.48±0.81). It also shows that there is a significant relationship (p<0.00) between incentives and job performance. Sonuç olarak; It is recommended to organize training courses for administrative leadership in the field of awards, the need to support and strengthen positive business relations between employees in non-sport sports institutions, incentives, human relations and employee evaluation methods, and to conduct a study on these incentives and improve work performance for other sports institutions.
Protein-centric omics analysis reveals circulating complements linked to non-viral liver diseases as potential therapeutic targets
Authors: Shi Yingzhou , Dong Hang , Sun Shiwei , Wu Xiaoqin , Fang Jiansong , Zhao Jianbo , Han Junming , Li Zongyue , Wu Huixiao , Liu Luna , Wu Wanhong , Tian Yang , Yuan Guandou , Fan Xiude , Xu Chao
Published: December 2023

Background/Aims: To evaluate the causal correlation between complement components and non-viral liver diseases and their potential use as druggable targets.Methods: We conducted Mendelian randomization (MR) to assess the causal role of circulating complements in the risk of non-viral liver diseases. A complement-centric protein interaction network was constructed to explore biological functions and identify potential therapeutic options.Results: In the MR analysis, genetically predicted levels of complement C1q C chain (C1QC) were positively associated with the risk of autoimmune hepatitis (odds ratio 1.125, 95% confidence interval 1.018–1.244), while complement factor H-related protein 5 (CFHR5) was positively associated with the risk of primary sclerosing cholangitis (PSC;1.193, 1.048– 1.357). On the other hand, CFHR1 (0.621, 0.497–0.776) and CFHR2 (0.824, 0.703–0.965) were inversely associated with the risk of alcohol-related cirrhosis. There were also significant inverse associations between C8 gamma chain (C8G) and PSC (0.832, 0.707–0.979), as well as the risk of metabolic dysfunction-associated steatotic liver disease (1.167, 1.036–1.314). Additionally, C1S (0.111, 0.018–0.672), C7 (1.631, 1.190–2.236), and CFHR2 (1.279, 1.059–1.546) were significantly associated with the risk of hepatocellular carcinoma. Proteins from the complement regulatory networks and various liver diseaserelated proteins share common biological processes. Furthermore, potential therapeutic drugs for various liver diseases were identified through drug repurposing based on the complement regulatory network.Conclusions: Our study suggests that certain complement components, including C1S, C1QC, CFHR1, CFHR2, CFHR5, C7, and C8G, might play a role in non-viral liver diseases and could be potential targets for drug development.
Recent advances in polymeric microparticle-based drug delivery systems for knee osteoarthritis treatment
Authors: Wang Guangxin , Zhang Xin-an , Kapilevich Leonid , Hu Mingjie
Published: December 2023

Due to the poor bioavailability and high joint clearance of drugs, sustained delivery of therapeutic agents has proven difficult in the treatment of osteoarthritis (OA). Intra-articular (IA) drug delivery strategy is an attractive option for enhancing OA patients’ prognosis, for which various polymer materials have been used as drug carriers due to their attractive delivery properties, to slow or even reverse the progress of OA by prolonging the duration of therapeutic agent residence in the joint. This article focuses on the recent developments in natural and synthetic polymer-based microsphere drug delivery systems for treating knee osteoarthritis. It evaluates the translational potential of some novel formulations for clinical application.
Plasminogen activator inhibitor 1 is associated with high-grade serous ovarian cancer metastasis and is reduced in patients who have received neoadjuvant chemotherapy
Authors: Kelly Tanya E. , Spillane Cathy L. , Ward Mark P. , Hokamp Karsten , Huang Yanmei , Tewari Prerna , Martin Cara M. , Norris Lucy A. , Mohamed Bashir M. , Bates Mark , Brooks Robert , Selemidis Stavros , Brooks Douglas A. , Kamran Waseem , Saadeh Feras Abu , O’Toole Sharon A. , O’Leary John J.
Published: December 2023

Introduction: High-grade serous ovarian cancer (HGSOC) is the most prevalent and deadliest subtype of epithelial ovarian cancer (EOC), killing over 140,000 people annually. Morbidity and mortality are compounded by a lack of screening methods, and recurrence is common. Plasminogen-activator-inhibitor 1 (PAI-1, the protein product of SERPIN E1) is involved in hemostasis, extracellular matrix (ECM) remodeling, and tumor cell migration and invasion. Overexpression is associated with poor prognosis in EOC. Platelets significantly increase PAI-1 in cancer cells in vitro, and may contribute to the hematogenous metastasis of circulating tumor cells (CTCs). CTCs are viable tumor cells that intravasate and travel through the circulation–often aided by platelets - with the potential to form secondary metastases. Here, we provide evidence that PAI-1 is central to the platelet-cancer cell interactome, and plays a role in the metastatic cascade.

Methods: SK-OV-3 cells where PAI-1 had been silenced, treated with healthy donor platelets, and treated with platelet-conditioned medium were used as an in vitro model of metastatic EOC. Gene expression analysis was performed using RNA-Seq data from untreated cells and cells treated with PAI-1 siRNA or negative control, each with and without platelets. Four cohorts of banked patient plasma samples (n = 239) were assayed for PAI-1 by ELISA. Treatment-naïve (TN) whole blood (WB) samples were evaluated for CTCs in conjunction with PAI-1 evaluation in matched plasma.

Results and discussion: Significant phenotypic changes occurring when PAI-1 was silenced and when platelets were added to cells were reflected by RNA-seq data, with PAI-1 observed to be central to molecular mechanisms of EOC metastasis. Increased proliferation was observed in cells treated with platelets. Plasma PAI-1 significantly correlated with advanced disease in a TN cohort, and was significantly reduced in a neoadjuvant chemotherapy (NACT) cohort. PAI-1 demonstrated a trend towards significance in overall survival (OS) in the late-stage TN cohort, and correlation between PAI-1 and neutrophils in this cohort was significant. 72.7% (16/22) of TN patients with plasma PAI-1 levels higher than OS cutoff were CTC-positive. These data support a central role for PAI-1 in EOC metastasis, and highlight PAI-1’s potential as a biomarker, prognostic indicator, or gauge of treatment response in HGSOC.
Signaling plasticity in the integrated stress response
Authors: Boone Morgane , Zappa Francesca
Published: December 2023

The Integrated Stress Response (ISR) is an essential homeostatic signaling network that controls the cell’s biosynthetic capacity. Four ISR sensor kinases detect multiple stressors and relay this information to downstream effectors by phosphorylating a common node: the alpha subunit of the eukaryotic initiation factor eIF2. As a result, general protein synthesis is repressed while select transcripts are preferentially translated, thus remodeling the proteome and transcriptome. Mounting evidence supports a view of the ISR as a dynamic signaling network with multiple modulators and feedback regulatory features that vary across cell and tissue types. Here, we discuss updated views on ISR sensor kinase mechanisms, how the subcellular localization of ISR components impacts signaling, and highlight ISR signaling differences across cells and tissues. Finally, we consider crosstalk between the ISR and other signaling pathways as a determinant of cell health.
Association between Parkinson's disease and the risk of adverse cardiovascular events: a systematic review and meta-analysis
Authors: Hu Yan , Xu Shanxia
Published: December 2023

Background

This review aims to examine the association of Parkinson's disease (PD) with the increased risk of cardiovascular events.

Methods

PubMed, Embase, CENTRAL, and Scopus databases were electronically searched for papers published up to 5 May 2023. Studies reporting the association between PD and the subsequent risks of stroke, myocardial infarction (MI), and cardiovascular mortality were included.

Results

Sixteen studies were included in this review. The clinical data of 101,712 PD patients were compared with that of the control group of 204,901 patients without PD in the included studies. Meta-analysis showed that PD patients had an increased risk of stroke compared with patients without PD (odds ratio (OR): 1.49; 95% confidence interval (CI): 1.30, 1.72; I2 = 76%). The pooled analysis demonstrated no significant increase in the risk of MI (OR: 1.16; 95% CI: 0.85, 1.59; I2 = 82%) and cardiovascular mortality (OR: 1.20; 95% CI: 0.93, 1.54; I2 = 65%) in PD patients. However, data from cohort studies indicated a possibility of higher risk of MI (OR: 1.36; 95% CI: 1.01, 1.84; I2 = 80%) and cardiovascular mortality (OR: 1.22; 95% CI: 1.00, 1.60; I2 = 62%) in patients with PD.

Conclusion

Patients with PD may have an increased risk of stroke as compared with the age- and gender-matched general population. While our results show that PD does not increase the overall risk of MI and cardiovascular mortality, analysis of cohort studies alone demonstrated that these risks may be higher in patients with PD. The current evidence is of very low quality. Further prospective cohort studies from different countries that would account for important cardiovascular risk factors are needed to improve the current evidence.

Systematic Review Registration

https://www.crd.york.ac.uk/prospero/, PROSPERO (CRD42023421924).
Performance investigation and mass transfer enhancement of a novel cone-type solar seawater still
Authors: Yang Jie , Chang Zehui , Zhang Xin , Zhu Guopeng
Published: December 2023

There are some disadvantages in the operating process of the basin solar seawater still (BSSS), such as long mass transfer distance, large heat indolence, huge floor space, and poor bearing pressure ability. A novel cone-type solar seawater still (CTSSS) is presented to overcome the weaknesses of the BSSS in this study. The CTSSS has the characteristics of seawater liquid film evaporation, short mass transfer distance, the condensation sleeve is parallel to and above the evaporation sleeve, and the condensation area is larger than the evaporation area. In order to clarify the performance of the CTSSS, the influence mechanism of feed seawater mass flow rate, heating power and heating temperature on the fresh water yield of the CTSSS was analyzed, the method of enhancing the mass transfer of the binary mixed gas in the CTSSS was explored, and the law of heat and mass transfer of the binary mixed gas in the annular enclosed small space was investigated. The results indicated that the maximum fresh water yield of the CTSSS is 62.7 g/20 min at the feed seawater mass flow rate of 400 g/h when the input power is 200 W, which is 4.5% higher than that when the feed seawater mass flow rate is 300 g/h. The performance ratio (PR) of the CTSSS is increased as the heating power, the PR of the CTSSS is 0.65 when 180 W heating power is employed. The steady state fresh water yield of the CTSSS with mirror condensation sleeve at 85°C is 84.6 g/20 min, which is 12.1% higher than that with non-mirror condensation sleeve Compared with the CTSSS with non-mirror condensation sleeve, the value of proportions of radiative heat transfer in the total heat transfer of the CTSSS with mirror condensation sleeve decreased by 6.6%, and the value of proportions of evaporative heat transfer increased by 6.4%. This study would provide a reference for small-scale decentralized application of solar desalination in remote areas.