bluuebunny/crossref_metadata_2025 huggingface dataset:
Unsur-Unsur Religi pada Kubur-Kubur Islam di Tuban
Authors: Najib Tubagus
Published: May 2020

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Mencermati Kembali Komoditas Lada Masa Kesultanan Banten Abad Ke-16-19
Authors: Sarjiyanto Sarjiyanto
Published: May 2020

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Perubahan Lingkungan Vegetasi di Kompleks Situs Candi Padang Roco dan Candi Pulau Sawah Sumatera Barat Berdasarkan Analisis Palinology
Authors: Vita Vita
Published: May 2020

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Periodisasi Candi Simangambat: Tinjauan Terhadap Beberapa Temuan Ragam Hias Candi
Authors: Susetyo Sukawati
Published: May 2020

Abstract. Periodization of Simangambat Temple: A Review on Some Temple Ornaments. Simangambat Temple is the ruin of a temple which is located in the southern part of North Sumatra Province. Some artefacts found during ground surveys and excavations vary from kala-shaped stones, makara, guirlande reliefs, garia, pillars, and 'kertas tempel' motifs. These findings show similarities to the artefacts found in the temples from Old Mataram era; hence it can be concluded that Simangambat Temple might have been built in the same period as the temples of Old Mataram era. Abstrak. Candi Simangambat merupakan suatu candi yang terletak di bagian Selatan Provinsi Sumatera Utara yang kondisinya sudah runtuh. Beberapa artefak yang ditemukan baik dari hasil penggalian maupun yang sudah berada di permukaan tanah yaitu batu-batu berbentuk kala; makara; batu berelief guirlande, gapa, pilar dan motif kertas tempel; menunjukkan kemiripan dengan artefak dari candi-candi zaman Mataram Kuna. Berdasarkan hal itu maka diduga bahwa Candi Simangambat dibangun sezaman dengan candi-candi dari jaman Mataram Kuna.
Konsep Open Air Museum: Alternatif Model Pelestarian Situs Arkeologi di Indonesia
Authors: Winaya Atina
Published: May 2020

Abstract. Open air museum is a kind of museum that exhibits its collections in an open space. In its development, it not only displays the collections outdoor, but also an attempt to preserve archaeological sites. The concept is already developed in advanced countries. Through this concept, an archaeological site was transformed into "life " again. Landscape and heritage buildings were reconstructed in accordance with the conditions in the past. Beside the tangible remains, the intangible remains were also reconstructed. Recently, people can obtain knowledge and experience about the atmosphere of the past. In Indonesia, the concept is rather new. The concept can be used as one of the solutions in order to optimally preserve archaeological sites. Significant values, both physical and non-physical, are well-developed to benefit the community. Thus, the meaning of the archaeological sites can be understood by today andfuture society, so it would grow the awareness of national identity and increase the patriotism. Abstrak. Open air museum adalah jenis museum yang memamerkan koleksinya di ruang terbuka. Dalam perkembangannya, open air museum tidak hanya memamerkan koleksinya secara outdoor, melainkan merupakan salah satu media dalam upaya pelestarian situs arkeologi. Konsep tersebut sudah banyak dikembangkan di negara-negara maju. Melalui konsep open air museum, suatu situs arkeologi berubah menjadi hidup kembali. Lansekap dan bangunan Cagar Budaya direkonstruksi sesuai dengan kondisinya di masa lalu. Selain tinggalan budaya tangible, tinggalan budaya intangible juga direkonstruksi kembali. Dengan demikian, masyarakat masa kini dapat memperoleh pengetahuan dan pengalaman mengenai suasana situs beserta kehidupannya di masa lampau. Konsep open air museum masih dapat dikatakan asing di Indonesia. Padahal jika dikaji lebih lanjut, konsep tersebut dapat dijadikan salah satu solusi dalam upaya pelestarian dan pemanfaatan situs secara optimal. Potensi-potensi yang terkandung di dalam situs, baik fisik maupun nilai, digali dan dikembangkan semaksimal mungkin, sehingga dapat memberikan manfaat bagi masyarakat. Dengan demikian, makna yang terkandung di dalam situs dapat dipahami oleh masyarakat masa kini dan masa yang akan datang sehingga menumbuhkan kesadaran akan identitas dan jati diri bangsa, serta meningkatkan rasa cinta tanah air.
Laporan Singkat Dinas Purbakala Tahun 1952
Authors: Puslit Arkenas Redaksi
Published: May 2020

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Beberapa Hasil Perjalanan
Authors: Puslit Arkenas Redaksi
Published: May 2020

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Kisah Harian
Authors: Puslit Arkenas Redaksi
Published: May 2020

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Redes Sociales Digitales en la comunicación con los consumidores de restaurantes de la zona gastronómica de Tijuana
Authors: Cruz-Estrada Isaac , Miranda-Zavala Ana María
Published: May 2020

Objetivo: identificar los factores que intervienen para que los consumidores utilicen las redes sociales digitales de los restaurantes de la zona gastronómica de Tijuana, que permita a las organizaciones mejorar su comunicación con el mercado meta. Metodología: se realizaron entrevistas en profundidad en tres agencias de mercadotecnia que brindan el servicio de marketing con redes sociales en las organizaciones de la zona. Se aplicaron 378 encuestas a clientes de cinco restaurantes de la zona gastronómica, para seleccionar las unidades en donde se aplicó el instrumento, se efectuó un trabajo de observación y comprobación de actividad en redes sociales digitales. Resultados: la plataforma que más utilizan las personas para buscar información de restaurantes es Facebook; los factores que favorecen el uso de las redes sociales digitales son el mantenimiento del contenido; la administración de relaciones con el cliente; publicación de precios y promociones; enlaces a sitios de Internet oficiales y descripción de los servicios. Limitaciones: se integraron en la muestra a empresas de la zona gastronómica de la ciudad de Tijuana con actividad en los medios digitales y que contaran con redes sociales activas, dejando para futuras investigaciones incluir a las empresas que no utilizan medios digitales, para realizar el comparativo. Conclusiones: los medios digitales, se han constituido como un componente importante de acceso a información y revisión de las opciones gastronómicas disponibles para los consumidores.
More Unnecessary Imaginary Worlds – Part 4: The ICER Evidence Report for Crizanlizumab, Voxelotor and L-Glutamine for Sickle Cell Disease
Authors: Langley Paul
Published: May 2020

A number of commentaries have been published over the past 4 years by the present author on the manifest flaws in the reference case value assessment framework of the Institute for Economic and Clinical Review. The recent release of the evidence report on sickle cell disease continues ICER’s commitment to what has been described as the creation of imaginary worlds to support value assessment. The purpose of the present commentary is to continue the critiques that have been presented for earlier evidence reports. This is important because of the apparent willingness to take ICER’s recommendations at face value rather than a critical review of the value assessment framework. The case presented here points to a  number of weaknesses in the ICER framework: (i) the fabrication of imaginary constructs with a lifetime cost-per-incremental QALY framework; (ii) the consequent failure to meet the standards of normal science; (iii) the illogical reliance of assumptions drawn from the literature to create future scenarios; (iv) the rejection of hypothesis testing in favor of  ‘approximate information’ and (v) a belief that in the construction of QALYS that the EQ-5D-3L utility scale has ratio properties. This last point is demonstrably false which means that the ICER value assessment framework collapses. It is impossible mathematically, a failure to meet the axioms of fundamental measurement, for an ordinal utility scale to be combined with time spent in a disease state. The result is that the pricing and access recommendations for Crizanlizumab, Voxelotor and L-glutamine in sickle cell disease (SCD) are complete nonsense and should be rejected.

 

Article Type: Commentary
Electronic cigarettes: How confident and effective are allergists, pulmonologists, and primary care physicians in their practice behavior?
Authors: Zhou Sherry S. , Baptist Alan P.
Published: May 2020

Background: There has been a striking increase in electronic cigarette (EC) use in the United States. The beliefs and practices toward ECs among physicians are unknown. Objective: The purpose of this study was to investigate EC practice patterns among
allergists, pulmonologists, and primary care physicians. Methods: An anonymous survey was sent to physicians. The survey contained 32 questions and addressed issues related to demographics, cessation counseling behaviors, personal use, and knowledge and beliefs about ECs.
Statistical analysis was performed by using analysis of variance, the Pearson χ2 test, Fisher exact test, and logistic regression. Results: A total of 291 physicians completed the survey (222 primary care physicians, 33 pulmonologists, and 36 allergists)
for a response rate of 46%. The allergists asked about tobacco cigarette use as frequently as did the pulmonologists and more than the primary care physicians (p < 0.001), but they rarely asked about EC use. The pulmonologists scored highest on self-reported knowledge on ECs,
although all the groups answered <40% of the questions correctly. The allergists did not feel as comfortable about providing EC cessation counseling as did the pulmonologists and primary care physicians (p < 0.001). All three groups were equally unlikely to recommend ECs
as a cessation tool for tobacco cigarette users. Conclusion: Allergists lacked knowledge and confidence in providing education and cessation counseling for EC users. As the number of patients who use these products continues to increase, there is an urgent need for all
physicians to be comfortable and knowledgeable with counseling about ECs.
Estudio sobre producción de H2 con hidroelectricidad para una economía de hidrógeno en Colombia
Authors: Carvajal Osorio Hernán , Babativa Jhon H. , Alonso Julio A.
Published: May 2020

Se presentan resultados de un estudio técnico-económico y ambiental sobre la producción de hidrógeno (H2) como vector energético, para una futura Economía de Hidrógeno en Colombia en aprovechamiento de abundantes recursos hidroeléctricos. Se calculó la producción y transporte de cierta cantidad de H2 (178 kg/h), para alimentar una ciudadela de 15,800 habitantes que utilizaría celdas de combustible para abastecerse parcialmente de electricidad y calor. Se tomó la central de Amoyá, Chaparral, Tolima, como prototipo para la producción de H2 por electrólisis. Se seleccionaron cinco celdas electrolizadoras, con consumo de 53.4 kWh/kg H2. Para el suministro de la energía del H2 se compararon dos opciones de transporte: por gasoducto de 313 km o por transmisión de electricidad por la red nacional para producir H2 cerca al usuario. Resultó más favorable la transmisión eléctrica, pero más costosa si la electricidad supera los $67/kWh. Como demostración, se instalaría dentro de la central un electrolizador acoplado a una celda de combustible para abastecer electricidad a los sistemas auxiliares de la planta. Este estudio no comprendió aplicaciones ni aspectos de seguridad del H2 .
An archaeological survey of the Cooloola Region, S.E. Queensland
Authors: McNiven Ian
Published: May 2020

Within the last decade a general model of Aboriginal subsistence and settlement has emerged for coastal southeast Queensland. Investigations have concentrated in two areas, Fraser Island (Devitt 1979, Lauer 1977, 1979) and Moreton Bay (Alfredson 1983, 1984, Crooks 1982, Draper 1978, Hall 1980, 1982a, 1984, Hall and Robins 1984, Richardson 1979, 1984, Robins 1983, Robins and Hall 1981, Stockton 1974, Walters 1980). The general ethnohistorical and archaeological scenario for these two areas suggests semi-permanent coastal settlement with a subsistence orientation to marine protein resources (Devitt 1979, Hall 1982). The coastal archaeological record between these two areas however remains virtually unknown.
Editorial
Authors: Hall Jay
Published: May 2020

1986 has been a very good year for archaeology in Queensland. As the following pages testify, fundamental research is being undertaken throughout the length and breadth of the state. Furthermore it is being carried out by researchers who hail from not only Queensland but institutions throughout Australia. Perhaps the most significant discovery reported this year was the site of Wallen Wallen Creek on North Stradbroke Island, Moreton Bay (see R. Neal and E. Stock, Nature 1986:618-621). While excavating a recent surface midden for salvage purposes, Rob Neal, a Ph.D candidate at Queensland University, discovered a deep (2.5m) deposit within a coastal dune which yielded a continuous human occupation sequence. Collaboration with geomorphologist Errol Stock from Griffith University established that two soil units were formed after the dune was laid down and that associated cultural material is relatively undisturbed. C14 dating revealed an internally consistent series of determinations which stretch to over 22,000 B.P. Present results indicate a dramatic increase in occupation intensity (as measured by discard rate) in the late Holocene (esp. after ca. 2,000 B.P.), a pattern which fits well with results from other research in this area (eg. Hall Robins QAR, Volume 1) as well as other parts of eastern Australia. This discovery has provided the Pleistocene-Holocene chronological framework that has been sought for the Moreton Region for several years now. Future analysis of Wallen Wallen Creek material promises to add much to our notions of cultural change in this and adjacent areas.
An open site survey of Koolburra Plateau, Cape York Peninsula
Authors: Lilley Ian
Published: May 2020

This paper describes the execution and results of an open site survey in the Koolburra Plateau of Cape York Peninsula (for a detail of study area see Flood 1986, this volume). The objective of the survey was to assess the nature and distribution of surface sites on and in the immediate vicinity of the plateau. It aimed to do this through an intensive examination of selected parts of the Echidna Creek catchment.
Hope Island: salvage excavation of a Kombumerri site
Authors: Walters Ian , Lauer Peter , Nolan Anna , Dillon Graham , Aird Michael
Published: May 2020

This paper reports the salvage excavations of a shell midden at Hope Island, Gold Coast City, southeast Queensland. Archaeological investigations were carried out in the Gold Coast region during the late 1960s and early 1970s (e.g. Haglund-Calley and Quinnell 1973; Haglund 1975, 1976), but as academic input into the area waned it became something of a folk theory in the mainstream Anglo-Saxon community that nothing worthwhile in the way of archaeological evidence remained in the area. The Kombumerri people, traditional owners who have never ceded title to their land, knew differently. This paper follows an extensive site recording program undertaken by the Kombumerri Cultural Centre and the Anthropology Museum, University of Queensland, which has clearly demonstrated the correctness of their view: material evidence of significance to the local Aboriginal community abounds within the Gold Coast City limits and its environs.
Archaeology of the Gyranda region, Dawson River, central Queensland
Authors: Morwood M.J. , Godwin L.
Published: May 2020

This paper presents the results of survey and excavation in the upper Dawson area of the Central Queensland Sandstone Belt, a sandstone-dominated environment bounded by the townships of Banana in the east, Blackall in the west, Springsure in the north and Injune in the south, and which includes the Central Queensland Highlands (Walsh 1984:1). The work was undertaken as part of the environmental impact study for the Gyranda Weir commissioned by Cameron McNamara for the Queensland Water Resources Commission (Morwood 1985, 1986; Godwin 1985). However, the results of the study, and the potential of the area for future research, have a wider interest.
Current Queensland archaeological research
Authors: Morwood Mike , Davidson Iain
Published: May 2020

The Department of Archaeology and Palaeoanthropology has continued its extensive and intensive involvement in research, some of which concerns material from Queensland.
Aboriginal shell middens at the mouth of the Maroochy River, southeast Queensland
Authors: McNiven Ian
Published: May 2020

This paper examines a series of shell midden and stone artefact sites located at the mouth of the Maroochy River, southeast Queensland. It represents the first detailed archaeological research undertaken on the Sunshine Coast since Jackson (1939) investigated a series of middens near Point Cartwright in the 1930's. The present study details the results of survey and excavation work, with a number of tentative hypotheses concerning late Holocene shellfishing behaviour, bevel-edged tool use, and "regionalization" of societal groupings.
Nara Inlet 1: a Holocene sequence from the Whitsunday Islands, central Queensland coast
Authors: Barker Bryce
Published: May 2020

This paper reports an archaeological excavation at Nara Inlet, Hook Island, one of the Whitsunday group off the central Queensland coast. The site, Nara Inlet 1, is a large rockshelter which returned a non-basal 14C date of 8150±80 bp. The excavation forms part of a wider study investigating prehistoric island use by Aborigines of the Whitsunday region as well as archaeological change in the Holocene Period.
Editorial
Authors: Hall Jay
Published: May 2020

As I write it is February 26th, 1992, about nine months later than QAR Volume 7 was projected to go to print. While it is customary for each year's issue to be published in the year following, this volume is over 18 months late. While I can plead all kinds of extenuating circumstances which resulted in this delay, the fault ultimately lies with The Editor. So, first up, I wish to apologise to you, patient QAR subscribers, for this lapse in delivery of the 1990 issue.
Cathedral Cave, a rockshelter in Carnarvon Gorge, Queensland
Authors: Beaton J.M.
Published: May 2020

Cathedral Cave is a large rockshelter site in the uplands of southeast central Queensland. In 1975 I excavated a sample of the site as part of a study into the regional prehistory of this remote part of Queensland. At that time, archaeological data of any kind for the state of Queensland was at a premium. At 1,727,000kmÂ², Queensland takes up about as much of the world's surface as do France, Italy, Spain, and Germany combined. Yet, by the early 1970's in this northeastern tropical and sub-tropical one-fifth of the Australian continent we had not quite a handful of archaeological studies. In 1963 R.V.S. Wright (1971) had broken ground in a rockshelter at Mushroom Rock, near Laura, on the spine of the Cape York Peninsula, and had also determined the human genesis of the massive shell mounds at Albatross Bay in the gulf waters of the west coast of the Peninsula. Laila Haglund (1976) had worked for several seasons during the years 1965 through 1968 at the Broadbeach cemetery site in the far southeastern corner of Queensland, and the years of 1960, 1962 and 1964 had seen John Mulvaney's classic excavations in the south-central Queensland highlands (Mulvaney and Joyce 1965). It would be a decade, and later, before these pioneering studies would be followed by regional reconnaissance and excavations programs such as those of Geoff Bailey (1977) who in 1972 followed on from Wright's work at Albatross Bay, my own in 1974 through 1977 in the southeastern uplands (Beaton 1977, 1982, 1991 - this volume, Beaton and Walsh 1977), Michael Morwood on the western slopes of the Dividing range (Morwood 1979, 1980, 1981), Jay Hall and associates in the Moreton Bay area (Hall 1982, Hall and Hiscock 1988), and John Campbell (Campbell 1982) in the northeast.
Raiders of the lost axe: on macropods, phalangers, where and why - comments on Sutton's comment on Morwood and Trezise (and Pleistocene Axes)
Authors: David Bruno
Published: May 2020

Although I agree with Sutton that we should take care to avoid presenting our data as 'fact' until suitably rigid procedures have been employed in the collection of data and in the testing of ideas, I think that Morwood and Tresize (1989) should be congratulated for presenting information on a poorly executed excavation undertaken over 20 years ago, the results of which may never have seen light of day were it not for their recent paper. Morwood and Tresize make it clear to the reader that uncertainties remain concerning the provenance of the lost axe and their broader discussion of the axe's implications should surely be read in the context of 'if' the axe indeed is of Pleistocene origin. It is only by discerned reading and testing of ideas that the line can be drawn between ' fact' and 'false fact' (although I think the line between them is finer than Sutton implies). The establishment of a 'fact' has to be argued at every level of information presentation from the statement that the axe once lay in situ in the gravelly deposits near bedrock at Sandy Creek 1, to the view that the item was in 'fact' an axe, to the dating of that level to over 30,000 years BP, and so on. For many of these levels of data presentation, it is often assumed that the reader is able to assess for him/herself whether or not the purported 'fact' contains enough information to withstand discerned testing (e.g. I accept that the item is indeed an axe/hatchet as defined by convention). In other cases, lack of sufficient data (other 'facts') precludes us from accepting other presented information (e.g. lack of adequate stratigraphic control in the original excavations have created a significant amount of doubt over the authenticity of a Pleistocene context for the axe). Morwood and Tresize's paper, it is felt, is no different from many other archaeological papers in that data is presented and theories are formulated. It is up to the reader to determine whether or not the data is of sufficient rigidity to warrant acceptance of ensuing theories (as is the case with other archaeological publications).
A Teoria da Decisão Judicial de Robert Alexy e a Dialética Hegeliana: Um Estudo da Aplicação do Princípio da Proporcionalidade no Brasil
Authors: Bussinguer Elda , Silva Gabrielle Saraiva , Zaganelli Juliana
Published: May 2020

Busca-se nesse artigo analisar se a dialética hegeliana confere maior racionalidade na aplicação da teoria da decisão judicial de Robert Alexy, tendo em vista a aplicação do princípio da proporcionalidade no Brasil. Primeira-mente, é apresentada a contextualização histórica da teoria da decisão judicial com o fim de, posteriormente, explicar o pensamento de Robert Alexy e suas influências teóricas no Brasil. Por fim, analisa-se qual a contribuição da dialética hegeliana na racionalidade inerente à teoria da decisão judicial no paradigma contem-porâneo, tendo em vista a importância da abordagem dialética pelo magistrado quando o mesmo se utilizada da teoria alexyana, uma vez que se torna mais racionalizada as decisões judiciais.
Avaliação do serviço de controle da tuberculose em uma unidade saúde da família no estado do Pará
Authors: Cardoso Raquel Ferreira , Pereira Átila Augusto Cordeiro , Ferreira Ilma Pastana , El-Husny Claudia Ozela , Da Costa Josias Botelho , Da Cruz Bianca Silva , Matos Brenda Soele Souza , De Oliveira Lohanna Rafaelle Lima , Marques Sara Edyele Santos , Cordovil Darciane Coelho
Published: May 2020

Objetivo: Avaliar o serviço de controle da tuberculose em uma Unidade Saúde da Família.  Métodos: Trata-se de um estudo avaliativo, descritivo e quantitativo, realizado com 11 profissionais em uma Unidade Saúde da Família no estado do Pará. As entrevistas ocorreram nos meses de agosto e setembro de 2019, com aplicação de um instrumento adaptado e validado pela Rede Brasileira de Pesquisa em tuberculose. Os dados foram analisados por meio de estatística descritiva no Google Forms e Excel 2013. O estudo foi aprovado pelo Comitê de Ética em Pesquisa. Resultados: As variáveis do componente Recursos Humanos, Oferta de capacitação em TB pela atenção Básica (54,5%) e Oferta de capacitação pelo PCT municipal (36,4%), apresentaram desempenho insatisfatório e crítico, respectivamente. Na organização do serviço, apenas o Acesso ao resultado de baciloscopia em 7 dias (63,6%) obteve um desempenho insatisfatório. O componente Processo foi o que mais apresentou variáveis com desempenho crítico. Conclusão: Existem fragilidades no serviço oferecido pela Unidade, sendo necessário o estabelecimento de estratégias e a adoção da avaliação permanente como uma ferramenta na busca de melhorias da qualidade da assistência.
O emocionar e o saber ser professor de um coletivo de fisioterapeutas
Authors: Thomé Roberta Tavares , Peixoto Renata da Silva , Laurino Débora Pereira , Rodrigues Sheyla Costa
Published: May 2020

Objetivo: Conhecer como os profissionais de Fisioterapia, transformam o conteúdo específico de sua área de conhecimento em conhecimento de ensino. Métodos: Estudo qualitativo realizado com dez professores graduados em Fisioterapia que atuam na sala de aula de uma Instituição de Ensino Superior (IES). A opção pelo conversar individual foi o método que nos pareceu adequado para o Estudo e envolveu perguntas com temas como o tempo de trabalho, a formação acadêmica e a decisão pela docência, práticas e técnicas utilizadas em sala de aula, recursos e avaliações do desempenho dos alunos que poderiam nos auxiliar a compreender o problema do estudo. A análise do conversar foi realizada pela técnica do Discurso do Sujeito Coletivo. Resultados: Formou os discursos coletivos que denominamos: DSC1 – O emocionar da docência; DSC2 – A prática da docência. O sujeito fisioterapeuta, pelas interações recorrentes foi sendo constituído na rede de conversação docente e, na convivência, foi se transformando no fazer e no emocionar da docência. Conclusão: Pelos atravessamentos com o fazer docente em sua trajetória de vida e pelas próprias experiências da ação, esses profissionais se produzem na docência na condição de sabedores de um conhecimento específico e de uma emoção que lhes move a fazer o que fazem.
Protonation, Tautomerism, and Base Pairing of the Antiviral Favipiravir (T-705)
Authors: da Silva Gabriel
Published: May 2020

Favipiravir (T-705) is an antiviral medication used to treat influenza. T-705 is also currently being trialled as a repurposed COVID-19 treatment. To help accelerate these efforts, this study provides important solution-phase properties of T-705 determined via computational chemistry. Density functional theory (DFT) calculations combined with the SMD continuum solvation model demonstrate that T-705 prefers the aromatic enol form in solution over the ketone tautomer. Deprotonation constants for the conjugate acids of T-705 (pKas) are then evaluated, by combining the DFT/SMD calculations with accurate G4 gas-phase basicities. These calculations indicate that T-705 is a weak base that should not significantly protonate at physiological pH. The preferential site for protonation is at the ring nitrogen ortho to the alcohol functional group (pKa ~ 7.4), followed by protonation of the oxygen on the amide side-chain at more acidic conditions (pKa ~ -9.8). Significantly, protonation of the ring nitrogen produces an acid that can deprotonate to the enol form (pKa ~ -5.1), providing a pathway for their interconversion. Finally, base-pairing of the active ribose-bound form of T-705 to cytidine and uridine is also examined. These calculations indicate that both base pairs have large binding free energies of around 4 – 5 kcal/mol, supporting previous findings that T-705 can bind with both nucleobases, leading to mis-incorporation of these pairs into viral RNA.
Naturally Occurring Anthraquinones as Potential Inhibitors of SARS-CoV-2 Main Protease: A Molecular Docking Study
Authors: Das Sourav , Singha Roy Atanu
Published: May 2020

Background: The novel coronavirus (COVID-19) has quickly spread throughout the globe, affecting millions of people. The World Health Organization (WHO) has recently declared this infectious disease as a pandemic. At present, several clinical trials are going on to identify possible drugs for treating this infection. SARS-CoV-2 Mpro is one of the most critical drug targets for the blockage of viral replication. Method: The blind molecular docking analyses of natural anthraquinones with SARS-CoV-2 Mpro were carried out in an online server, SWISSDOCK, which is based on EADock DSS docking software. Results: Blind molecular docking studies indicated that several natural antiviral anthraquinones could prove to be effective inhibitors for SARS-CoV-2 Mpro of COVID-19 as they bind near the active site having the catalytic dyad, HIS41 and CYS145 through non-covalent forces. The anthraquinones showed less inhibitory potential as compared to the FDA approved drug, remdesivir. Conclusion: Among the natural anthraquinones, alterporriol Q could be the most potential inhibitor of SARS-CoV-2 Mpro among the natural anthraquinones studied here, as its ∆G value differed from that of remdesivir only by 0.51 kcal/ mol. The uses of these alternate compounds might be favorable for the treatment of the COVID-19.
Mycobacterium Survival Strategy Translated to Develop a Lipo-Peptide Based Fusion Inhibitor
Authors: Sardar Avijit , Lahiri Aritraa , Mallick Amirul Islam , Tarafdar Pradip Kumar
Published: May 2020

The entry of enveloped viruses requires fusion of viral and host cell membranes. An effective fusion inhibitor aiming at impeding such virus-host cell membrane fusion may emerge as a broad-spectrum antiviral agent to neutralize the infection from an increasing diversity of harmful new viruses. Mycobacterium survives inside the phagosome of the host cells by inhibiting phagosome-lysosome fusion with the help of a coat protein coronin 1. Structural analysis of coronin 1 and other WD40-repeat containing protein suggest that the tryptophan-aspartic acid (WD) sequence is placed at distorted β-meander motif (more exposed) whereas the WD resides in regular β-meander motif in other WD40 proteins. The unique structural feature of coronin 1 was explored to identify a simple lipo-peptide sequence (lipid-WD), which effectively inhibit the membrane fusion by increasing interfacial order and decreasing water penetration, surface potential. The effective fusion inhibitory role of mycobacterium inspired lipo-dipeptide was applied to combat type 1 influenza virus (H1N1) infection as a ‘broad spectrum’ antiviral agent.
Automated Framework for Developing Predictive Machine Learning Models for Data-Driven Drug Discovery
Authors: Neves Bruno J. , Moreira-Filho José T. , Silva Arthur C. , Borba Joyce V. V. B. , Mottin Melina , Alves Vinicius , Braga Rodolpho C. , Muratov Eugene , Andrade Carolina
Published: May 2020

In this manuscript we describe the development of an automated framework for the curation of chemogenomics data and to develop QSAR models for virtual screening using the open-source KNIME software. The workflow includes four modules: (i) dataset preparation and curation; (ii) chemical space analysis and structure-activity relationships (SAR) rules; (iii) modeling; and (iv) virtual screening (VS). As case studies, we applied these workflows to four datasets associated with different endpoints. The implemented protocol can efficiently curate chemical and biological data in public databases and generates robust QSAR models. We provide scientists a simple and guided cheminformatics workbench following the best practices widely accepted by the community, in which scientists can adapt to solve their research problems. The workflows are freely available for download in GitHub.
Accelerated Modeling of Lithium Diffusion in Solid State Electrolytes Using Artificial Neural Networks
Authors: Rao Karun Kumar , Yao Yan , Grabow Lars
Published: May 2020

There is great interest in solid state lithium electrolytes to replace the flammable organic electrolyte for an all solid state battery. Previous efforts trying to understand the structure-function relationships resulting in high ionic conductivity materials have mainly relied on ab initio molecular dynamics. Such simulations, however, are computationally demanding and cannot be reasonably applied to large systems containing more than a few hundred atoms. Herein, we investigate using artificial neural networks (ANN) to accelerate the calculation of high accuracy atomic forces and energies used during molecular dynamics (MD) simulations, to eliminate the need for costly ab initio force and energy evaluation methods, such as density functional theory (DFT). After carefully training a robust ANN for four and five element systems, we obtain nearly identical lithium ion diffusivities for Li10GeP2S12 (LGPS) when benchmarking the ANN-MD results with DFT-MD. To demonstrate the power of the outlined ANN-MD approach we apply it to a doped LGPS system to calculate the effect of concentrations of chlorine on the lithium diffusivity at a resolution that would be unrealistic to model with DFT-MD. We find that ANN-MD simulations can provide the framework to study systems that require a large number of atoms more efficiently while maintaining high accuracy.
Synthesis of Novel Selenocyanates and Evaluation of Their Effect in Cultured Mouse Neurons Submitted to Oxidative Stress
Authors: Frizon Tiago Elias Allievi , Cararo José H. , Saba Sumbal , Dal-Pont Gustavo C. , Michels Monique , Braga Hugo de C. , Pimentel Tairine , Dal-Pizzol Felipe , Valvassori Samira Silva , Rafique Jamal
Published: May 2020

Herein we report the synthesis of novel selenocyanates and assessment of their effect on the oxidative challenge elicited by hydrogen peroxide (H2O2) in cultured mouse neurons. First, α-methylene-β-hydroxy esters were prepared as precursors of allylic bromides. A reaction involving the generated bromides and sodium selenocyanate was conducted to produce the desired selenocyanates (3a-f). We next prepared cultures of neurons from 7-day-old-mice (n = 36). H2O2 (10⁻5 M) was added into the culture flasks as an oxidative stress inducer, alone or combined with one of each designed compounds. PhSe)2 was used as positive control. It was carried out assessment of lipid (thiobarbituric acid reactive species, 4-hydroxy-2’-nonenal, 8-isoprostane), DNA (8-hydroxy-2’-deoxyguanosine) and protein (carbonyl) modification parameters. Finally, catalase and superoxide dismutase activities were also evaluated. Among the compounds, 3b, 3d and 3f exhibited the most pronounced pattern of antioxidant activity, similar to (PhSe)2. These novel aromatic selenocyanates could be promising to be tried in most sophisticated in vitro studies or even at preclinical level.
Mechanically-Tunable Quantum Interference in Ferrocene-Based Single-Molecule Junctions
Authors: Camarasa-Gómez María , Hernangómez-Pérez Daniel , Inkpen Michael S. , Lovat Giacomo , Fung E-Dean , Roy Xavier , Venkataraman Latha , Evers Ferdinand
Published: May 2020

Ferrocenes are ubiquitous organometallic building blocks that comprise a Fe atom sandwiched between two cyclopentadienyl (Cp) rings that rotate freely at room temperature. Of widespread interest in fundamental studies and real-world applications, they have also attracted

some interest as functional elements of molecular-scale devices. Here we investigate the impact of

the configurational degrees of freedom of a ferrocene derivative on its single-molecule junction

conductance. Measurements indicate that the conductance of the ferrocene derivative, which is

suppressed by two orders of magnitude as compared to a fully conjugated analog, can be modulated

by altering the junction configuration. Ab initio transport calculations show that the low conductance is a consequence of destructive quantum interference effects that arise from the hybridization of metal-based d-orbitals and the ligand-based π-system. By rotating the Cp rings, the hybridization, and thus the quantum interference, can be mechanically controlled, resulting in a conductance modulation that is seen experimentally.
The anti-respiratory syncytial virus activity of methanol leaf extract of Aspilia africana
Authors: Damian C. Odimegwu  , Agatha I. Onah
Published: May 2020

Respiratory syncytial virus (RSV), to date, is still the most frequent cause of infantile and childhood cause of viral lower respiratory tract illness on a global scale, and at the same time, causing significant impact in the elderly. Presently, there is no licensed vaccine or safe and specific antiviral agent that could be used against the virus. Medicinal plants are known to be a promising source for the discovery of utilizable anti-RSV treatments. In this present study, we screened the anti-RSV and cell cytotoxicity activities of methanol extract of A. Africana by virus plaque reduction and corresponding cell viability methods in Hep-2 and Vero cells of human and mammalian origin respectively. The corresponding set up for analyses of A. Africana extract on cell viability were performed by the reduction of thiazolyl blue tetrazolium bromide (MTT) in the Hep-2 cells following the established method. The results of an evaluation of the extract of A. africana showed anti-RSV activities with inhibition of RSV at IC50, 42.5 ± 8.89, while the cell cytotoxic effect in Hep2 cells recorded was TC50, 121.4. ± 7.21. Therefore, our results show that the methanol extract of AA exhibited anti-RSV activities and has a moderate effect on the cell viability of the recipient host cell, indicating that target molecular substances against RSV can be developed from the extract.
Development of Lightboard-Based Flipped Classroom Learning Videos on Parabolic Motion Materials
Authors: La Aca Arman , Sulisworo Dwi
Published: May 2020

This study aims to produce lightboard-based flipped classroom learning videos on parabolic motion materials that are suitable for use as learning media. This type of research is ADDIE, which aims to produce a products with product validity from material experts, media experts, and physics teachers. The assessment of the feasibility level of the material expert was 94%, media expert 91.5%, and physics teacher 95%. The average level of feasibility of this learning video is 94%. The results of the assessment of 32 students as a feasibility trial for video lightboard obtained results from aspects of the material 88.15%, the effect on learning 91.41%, audiovisual display 90.10%, and language 90.36%. The average result of the feasibility of a video lightboard trial was 90.01%. From the results of the feasibility assessment it can be concluded that this learning video is categorized as very appropriate to be used as a learning media. This research can be used as a reference in producing effective and efficient learning media.
Whether it is worth Being Fond of Big Data?
Authors: Shuremov E. L.
Published: May 2020

The paper considers the analysis of the development of artificial intelligence systems. There were methods of analysis, comparison and deduction applied. Despite important achievements at the solution of some private tasks and big financing, the industry in general faces serious problems of development. Already in the nearest future the shortage of computing power will become serious restriction of deep machine learning. A review of literature showed that the commercialization of artificial intelligence and big data negatively affects the solution of fundamental problems in the industry development. The author shows that priorities of developers of systems of artificial intelligence are more and more displaced towards realization of simple consumer services while the solution of tasks, really important for all mankind, is not implemented. Dangers of misunderstanding by people of mechanisms of decisions development are revealed by intellectual computer systems. It is specified the signs allowing to assume possibility of global economic problems because of the developing pessimism of investors concerning prospects of the companies engaged in this field. The principal results of the study are recommended to specialists in the development of artificial intelligence systems as a part of a big data creation.
Improving the Methodology for Assessing the Level of Financial Security of Agricultural companies
Authors: Anikina I. D. , Kucherovа E. P. , Karevа E. S.
Published: May 2020

The paper is devoted to the study of approaches to assessing the financial security level of agricultural companies and their improvement. The methodological base of the research is a modern concept of financial security and enterprise sustainability. The methods review for assessing financial security is carried out, also industry characteristics of enterprises are studied. The result of the work is the development of a methodology for assessing the financial security level of organizations. Such methodology’s topicality is represented in the additive model, which includes four integral indicators: profitability, financial sustainability, solvency and business activity. The total of all integral indicators, taking into account the coefficients, is the final rate of an organization’s financial security. The authors distinguish three financial security levels, which are: critical, medium and high. The minimal coefficients, suggested by the legislation and minimal indicators adjusted according to the agricultural enterprises’ specificity have been given to calculate the critical level. The medium level is determined by the calculation of the agricultural producers’ financial security industry average over the last 5 years. The high financial security group includes the enterprises with the indicators exceeding the medium indicators. The theoretical and practical significance of the study lies in the fact that the proposed methodology makes it possible to assess the level of financial security of agricultural enterprises taking into account the industry specifics of their activities, including for further competitive analysis.
Skazane Niezależne Zrzeszenie Studentów Uniwersytetu Gdańskiego
Authors: Biernacki Leszek
Published: May 2020

W artykule opisano aresztowanie, przebieg procesu i uwięzienie studentów Uniwersytetu Gdańskiego w stanie wojennym. Po 13 grudnia 1981 roku drukowali nielegalne ulotki i biuletyny. Już 20 grudnia zostali aresztowani, a 3 lutego 1982 roku skazani przed Sądem Marynarki Wojennej w Gdyni: Cezary Godziuk na 6 lat pozbawienia wolności i 4 lata pozbawienia praw publicznych, Sławomir Sadowski – odpowiednio 5 lat i 3 lata, Krzysztof Jankowski – 5 lat i 3 lata, Jarosław Skowronek – 5 lat i 3 lata, Marek Czachor – 3 i 2 lata. Były to najwyższe wyroki w Polsce orzeczone wobec studentów. Władze stanu wojennego, obawiając się nielegalnych działań na uczelniach wyższych i manifestacji ulicznych w Gdańsku, chciały zastraszyć środowisko akademickie i stąd tak wysokie wyroki. Podczas procesu złamano podstawowe zasady jego prowadzenia. Umożliwiło to później wniesienie skutecznej apelacji od wyroku. Uwięzieni nie załamali się, nie donieśli na innych działaczy NZS kontynuujących działalność w podziemiu. W więzieniach podjęli samokształcenie, licząc na powrót na studia. Było to możliwe, bo mimo nacisków prokuratury i aparatu partyjnego rektor Robert Głębocki – a w ślad za nim komisje dyscyplinarne – uważał, że za ten sam czyn nie można karać dwukrotnie. Dlatego wobec żadnego studenta UG, który został ukarany przed kolegium ds. wykroczeń albo przed sądem za działalność polityczną, komisje dyscyplinarne nie wydały postanowienia o wyrzuceniu ze studiów. Wszyscy skazani przed Sądem Marynarki Wojennej zostali zwolnieni z odbywania kary w 1983 roku i wrócili na studia, które udało im się ukończyć. Ich postawa, jak i władz uczelni oraz większości środowiska akademickiego, jest jedną z jasnych kart historii Uniwersytetu Gdańskiego.
Jeszcze o ppor. mar. Ludwiku Habaju i promie uratowanym przezeń 24 grudnia 1945 roku
Authors: Kijowski Maciej
Published: May 2020

W latach 2018–2019 ukazały się w periodykach wydawanych w Gdyni i Pucku cenne publikacje poświęcone bogatej biografii Ludwika Habaja, marynarza urodzonego w Rzeszowie w 1900 roku. Z nieznanych przyczyn zabrakło w nich informacji o jego służbie w latach 1945–1946 w Morskiej Milicji Obywatelskiej, w tym o heroicznym uratowaniu pasażerów i członków załogi promu 24 grudnia 1945 roku. Autor niniejszego szkicu pragnie wypełnić tę lukę i oddać cześć bohaterowi.
POWER REDUCTION TECHNIQUES IN VLSI
Authors: Sharma Mehar , Gupta Neeraj , Gupta Rashmi
Published: May 2020

The paper investigates different level of techniques used for power reduction in VLSI. Before,most of the researches were oriented towards bringing about high speed and miniaturization.At present, because of the increasing trend of compact devices, the requirement for low powerconsuming circuits have also increased. This necessitates the need to align the research forreducing power dissipation in VLSI circuits. In the given paper we will briefly discuss aboutthe different types of power reduction techniques at design abstraction level which are adoptedin industries now-a-days. The comparison of traditional techniques and present techniquesare also covered in this paper.
HIGH SPEED ADDER USING GDI TECHNIQUE
Authors: Solomon Merrin Mary , Gupta Neeraj , Gupta Rashmi
Published: May 2020

Full adder is an important component for designing a processor. As the complexity of the circuit increases, the speed of operation becomes a major concern. Nowadays there are various architectures that exist for full adders. In this paper we will discuss about designing a low power and high speed full adder using Gate Diffusion Input technique. GDI is one of the present day methods through which one can design logical circuits. This technique will reduce power consumption, propagation delay, and area of digital circuits as well as maintain low complexity of logic design. The performance of the proposed design is compared with the contemporary full adder designs.
PARAMETER DETERMINATION OF HYDRAULIC DYNAMOMETER
Authors: Khan Mohammad Ayub , Singh Suraj , Om  , Gupta Gunjan , Yadav Avanish
Published: May 2020

The project is basically based upon the determination of parameters of Hydraulic Dynamometer using LabVIEW. LabVIEW is the programming tool that is used for automation purposes mainly in industries. Herein, we will be judging the various parameters like Load Cell, Temperature Sensors etc, by interfacing the digital set-up with our manual set-up. The Load Cell that will be used is the S-shaped Load Cell and the various temperature sensors are used to determine temperatures like water inlet temperature, water outlet temperature, air temperature etc. After measuring these parameters we will be interfacing these devices with the manual dynamometer system. After interfacing, there will be separate meters installed wherein we will be view parameters measured by the system.

The study that was conducted resulted in following results that are mentioned in the graphs and tables below. We have tried to mention more and more tables and graphs related to our study so that it can be possible to figure out the exact motive behind the research conducted.
SMART CITY TO INTELLIGENT HOUSES: FUTURISTIC SUSTAINABILITY APPROACH
Authors: Kantharia Mohan
Published: May 2020

Human comfort is the key factor in all kind of developments, for this natural resources are exploitation is being continued. Though energy production have increased tremendously, but population growth rate is more than the development rate. Hence there is always scarcity of the electricity, safe drinking water. Intelligent houses with smart traffic, smart irrigation can make smart city and provide some solutions for these problems. In these review paper solutions of some common society problems with sensor based automation in infrastructure has been discussed. Major areas of overview are intelligent buildings, smart ventilation of buildings, integration of solar panels with smart roof, smart traffics control, and smart irrigation system etc. These smart systems not only saving energy, and water but also reducing the cost hence desirable. Though this arrangement need so many sensors, control system, management system, computer internets network hence complicated but solving our problems smartly. The future time will be of smart infrastructure.