bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Strategies for Bioremediation of Emerging Pollutants: A Review for a Green and Sustainable Environment
Authors: Bala Saroj , Garg Diksha , Thirumalesh Banjagere Veerabhadrappa , Sharma Minaxi , Sridhar Kandi , Inbaraj Baskaran Stephen , Tripathi Manikant
Published: August 2022

Environmental pollution brought on by xenobiotics and other related recalcitrant compounds have recently been identified as a major risk to both human health and the natural environment. Due to their toxicity and non-biodegradability, a wide range of pollutants, such as heavy metals, polychlorinated biphenyls, plastics, and various agrochemicals are present in the environment. Bioremediation is an effective cleaning technique for removing toxic waste from polluted environments that is gaining popularity. Various microorganisms, including aerobes and anaerobes, are used in bioremediation to treat contaminated sites. Microorganisms play a major role in bioremediation, given that it is a process in which hazardous wastes and pollutants are eliminated, degraded, detoxified, and immobilized. Pollutants are degraded and converted to less toxic forms, which is a primary goal of bioremediation. Ex situ or in situ bioremediation can be used, depending on a variety of factors, such as cost, pollutant types, and concentration. As a result, a suitable bioremediation method has been chosen. This review focuses on the most recent developments in bioremediation techniques, how microorganisms break down different pollutants, and what the future holds for bioremediation in order to reduce the amount of pollution in the world.
Isolation, Characterization and Biological Action of Type-1 Ribosome-Inactivating Proteins from Tissues of Salsola soda L.
Authors: Landi Nicola , Ragucci Sara , Citores Lucía , Clemente Angela , Hussain Hafiza Z. F. , Iglesias Rosario , Ferreras José M. , Di Maro Antimo
Published: August 2022

Ribosome-inactivating proteins (RIPs) are known as RNA N-glycosylases. They depurinate the major rRNA, damaging ribosomes and inhibiting protein synthesis. Here, new single-chain (type-1) RIPs named sodins were isolated from the seeds (five proteins), edible leaves (one protein) and roots (one protein) of Salsola soda L. Sodins are able to release Endo’s fragment when incubated with rabbit and yeast ribosomes and inhibit protein synthesis in cell-free systems (IC50 = 4.83–79.31 pM). In addition, sodin 5, the major form isolated from seeds, as well as sodin eL and sodin R, isolated from edible leaves and roots, respectively, display polynucleotide:adenosine glycosylase activity and are cytotoxic towards the Hela and COLO 320 cell lines (IC50 = 0.41–1200 nM), inducing apoptosis. The further characterization of sodin 5 reveals that this enzyme shows a secondary structure similar to other type-1 RIPs and a higher melting temperature (Tm = 76.03 ± 0.30 °C) and is non-glycosylated, as other sodins are. Finally, we proved that sodin 5 possesses antifungal activity against Penicillium digitatum.
A Long-Read Genome Assembly of a Native Mite in China Pyemotes zhonghuajia Yu, Zhang & He (Prostigmata: Pyemotidae) Reveals Gene Expansion in Toxin-Related Gene Families
Authors: Song Yan-Fei , Yu Li-Chen , Yang Mao-Fa , Ye Shuai , Yan Bin , Li Li-Tao , Wu Chen , Liu Jian-Feng
Published: August 2022

Pyemotes zhonghuajia Yu, Zhang & He (Prostigmata: Pyemotidae), discovered in China, has been demonstrated as a high-efficient natural enemy in controlling many agricultural and forestry pests. This mite injects toxins into the host (eggs, larvae, pupae, and adults), resulting in its paralyzation and then gets nourishment for reproductive development. These toxins have been approved to be mammal-safe, which have the potential to be used as biocontrol pesticides. Toxin proteins have been identified from many insects, especially those from the orders Scorpions and Araneae, some of which are now widely used as efficient biocontrol pesticides. However, toxin proteins in mites are not yet understood. In this study, we assembled the genome of P. zhonghuajia using PacBio technology and then identified toxin-related genes that are likely to be responsible for the paralytic process of P. zhonghuajia. The genome assembly has a size of 71.943 Mb, including 20 contigs with a N50 length of 21.248 Mb and a BUSCO completeness ratio of 90.6% (n = 1367). These contigs were subsequently assigned to three chromosomes. There were 11,183 protein coding genes annotated, which were assessed with 91.2% BUSCO completeness (n = 1066). Neurotoxin and dermonecrotic toxin gene families were significantly expanded within the genus of Pyemotes and they also formed several gene clusters on the chromosomes. Most of the genes from these two families and all of the three agatoxin genes were shown with higher expression in the one-day-old mites compared to the seven-day-pregnant mites, supporting that the one-day-old mites cause paralyzation and even death of the host. The identification of these toxin proteins may provide insights into how to improve the parasitism efficiency of this mite, and the purification of these proteins may be used to develop new biological pesticides.
Immobilization of Microbes for Biodegradation of Microcystins: A Mini Review
Authors: Zhang Jiajia , Wei Jia , Massey Isaac Yaw , Peng Tangjian , Yang Fei
Published: August 2022

Harmful cyanobacterial blooms (HCBs) frequently occur in eutrophic freshwater ecosystems worldwide. Microcystins (MCs) are considered to be the most prominent and toxic metabolites during HCBs. MCs may be harmful to human and animal health through drinking water and recreational water. Biodegradation is eco-friendly, cost-effective and one of the most effective methods to remove MCs. Many novel MC-degrading bacteria and their potential for MCs degradation have been documented. However, it is a challenge to apply the free MC-degrading bacterial cells in natural environments due to the long-term operational instability and difficult recycling. Immobilization is the process of restricting the mobility of bacteria using carriers, which has several advantages as biocatalysts compared to free bacterial cells. Biological water treatment systems with microbial immobilization technology can potentially be utilized to treat MC-polluted wastewater. In this review article, various types of supporting materials and methods for microbial immobilization and the application of bacterial immobilization technology for the treatment of MCs-contaminated water are discussed. This article may further broaden the application of microbial immobilization technology to the bioremediation of MC-polluted environments.
Cardiovascular Manifestation of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents
Authors: Mansanguan Suyanee , Charunwatthana Prakaykaew , Piyaphanee Watcharapong , Dechkhajorn Wilanee , Poolcharoen Akkapon , Mansanguan Chayasin
Published: August 2022

This study focuses on cardiovascular manifestation, particularly myocarditis and pericarditis events, after BNT162b2 mRNA COVID-19 vaccine injection in Thai adolescents. This prospective cohort study enrolled students aged 13–18 years from two schools, who received the second dose of the BNT162b2 mRNA COVID-19 vaccine. Data including demographics, symptoms, vital signs, ECG, echocardiography, and cardiac enzymes were collected at baseline, Day 3, Day 7, and Day 14 (optional) using case record forms. We enrolled 314 participants; of these, 13 participants were lost to follow-up, leaving 301 participants for analysis. The most common cardiovascular signs and symptoms were tachycardia (7.64%), shortness of breath (6.64%), palpitation (4.32%), chest pain (4.32%), and hypertension (3.99%). One participant could have more than one sign and/or symptom. Seven participants (2.33%) exhibited at least one elevated cardiac biomarker or positive lab assessments. Cardiovascular manifestations were found in 29.24% of patients, ranging from tachycardia or palpitation to myopericarditis. Myopericarditis was confirmed in one patient after vaccination. Two patients had suspected pericarditis and four patients had suspected subclinical myocarditis. In conclusion, Cardiovascular manifestation in adolescents after BNT162b2 mRNA COVID-19 vaccination included tachycardia, palpitation, and myopericarditis. The clinical presentation of myopericarditis after vaccination was usually mild and temporary, with all cases fully recovering within 14 days. Hence, adolescents receiving mRNA vaccines should be monitored for cardiovascular side effects. Clinical Trial Registration: NCT05288231.
Factors Affecting the Transition from Paper to Digital Data Collection for Mobile Tuberculosis Active Case Finding in Low Internet Access Settings in Pakistan
Authors: Mergenthaler Christina , Mathewson Jake D. , Latif Abdullah , Tahir Hasan , Meurrens Vincent , van Werle Andreas , Rashid Aamna , Tariq Muhammad , Ahmed Tanveer , Naureen Farah , Rood Ente
Published: August 2022

Between September 2020 and March 2021, Mercy Corps piloted hybrid digital (CAPI) and paper-based (PAPI) data collection as part of its tuberculosis (TB) active case finding strategy. Data were collected using CAPI and PAPI at 140 TB chest camps in low Internet access areas of Punjab and Khyber Pakhtunkhwa provinces in Pakistan. PAPI data collection was performed primarily during the camp and entered using a tailor-performed CAPI tool after camps. To assess the feasibility of this hybrid approach, quality of digital records were measured against the paper “gold standard”, and user acceptance was evaluated through focus group discussions. Completeness of digital data varied by indicator, van screening team, and month of implementation: chest camp attendees and pulmonary TB cases showed the highest CAPI/PAPI completeness ratios (1.01 and 0.96 respectively), and among them, all forms of TB diagnosis and treatment initiation were lowest (0.63 and 0.64 respectively). Vans entering CAPI data with high levels of completeness generally did so for all indicators, and significant differences in mean indicator completeness rates between PAPI and CAPI were observed between vans. User feedback suggested that although the CAPI tool required practice to gain proficiency, the technology was appreciated and will be better perceived once double entry in CAPI and PAPI can transition to CAPI only. CAPI data collection enables data to be entered in a more timely fashion in low-Internet-access settings, which will enable more rapid, evidence-based program steering. The current system in which double data entry is conducted to ensure data quality is an added burden for staff with many activities. Transitioning to a fully digital data collection system for TB case finding in low-Internet-access settings requires substantial investments in M&E support, shifts in data reporting accountability, and technology to link records of patients who pass through separate data collection stages during chest camp events.
On Possible Origin of an Artificial Wormhole
Authors: Kirillov Alexander A. , Savelova Elena P.
Published: August 2022

We assume the picture in which a vacuum is filled with virtual wormholes. The presence of external fields changes the distribution of virtual wormholes and, in principle, allows for the creation of a coherent structure that can work as an actual wormhole or the Alcubierre bubble. We establish the explicit functional relationship between the external field and the distribution of virtual wormholes in vacuum. This opens a way for examining the question about the possibility of the artificial creation of such objects in a laboratory. We show that weak and quasihomogeneous fields suppress the density of wormholes and cannot be used. We also discuss the existence of a threshold for the intensity of an external field beyond which the formation of wormhole-type structures becomes possible.
Stark Broadening of Zn III Spectral Lines
Authors: Dimitrijević Milan S. , Christova Magdalena D.
Published: August 2022

Stark widths for spectral lines within 24 multiplets of Zn III singlets and triplets have been calculated using modified semiempirical method for an electron density of 1017 cm−3 and temperatures from 5000 K up to 100,000 K. The obtained results have been used for the investigation of the influence of Stark broadening on Zn III spectral lines in stellar atmospheres and for the considerations of Stark width similarites within supermultiplets and transition arrays.
Properties and Dynamics of Neutron Stars and Proto-Neutron Stars
Authors: Dexheimer Veronica
Published: August 2022

This Special Issue provides a comprehensive collection of papers that present modern theories to describe neutron star interiors and dynamics [...]
A Preliminary Study of Summer Thermo-Hygrometric Comfort under Different Environmental Conditions in a Mediterranean City
Authors: Falasca Serena , Di Bernardino Annalisa , Ciancio Virgilio , Curci Gabriele , Salata Ferdinando
Published: August 2022

The thermo-hygrometric sensation of pedestrians in outdoor environments can be quantified by means of bioclimatic indices. In this work, the Mediterranean Outdoor Thermal Comfort Index (MOCI) is applied in the city of Rome (Italy) for the purpose of investigating the effect of local environmental conditions (urban, suburban, rural) on pedestrian thermal comfort. Hourly values of MOCI are calculated for the May–September period in the years 2015–2021 using weather quantities acquired by the four monitoring stations of the Regional Agency for Environmental Protection included in the metropolitan area of Rome. MOCI data are analyzed based on the comfort and (cold/hot) discomfort conditions during both daytime and nighttime. At the urban station, 26% of daily records exceed the comfort threshold revealing the effect of urban overheating, whereas only 0.1% of hot discomfort occurrences are recorded overnight. Here, greater nighttime thermal comfort is experienced than in non-urban locations suggesting that the nocturnal thermo-hygrometric conditions are satisfactory for inhabitants in downtown Rome, despite the urban heat island. It also suggests that other factors, such as orography and atmospheric circulation, influence outdoor thermal comfort. The development of this work will therefore include at least these two elements.
On Spatial Mechanisms of Social Equity: Exploring the Associations between Street Networks, Urban Compactness, and Social Equity
Authors: Rashid Mahbub
Published: August 2022

In several publications between 1998 and 2003, Elizabeth Burton examined whether urban compactness promotes social equity. Based on an extensive literature review, Burton developed numerous urban compactness and social equity measures. Using a sample of 25 free-standing English cities of different sizes, her studies found that urban compactness measures are often statistically correlated with social equity measures in these cities. Extending Burton’s studies, this study explores the correlations between the measures of street networks, urban compactness, and social equity in the same 25 cities that Burton studied. Correlational analyses revealed that street network measures are correlated differently with different urban compactness and social equity measures. Some street network measures are not statistically correlated with social equity and urban compactness measures. Some are statistically correlated with urban compactness measures, but not with social equity measures. Yet others are statistically correlated with social equity measures, but not with urban compactness. Still others are statistically correlated with both social equity and urban compactness measures. Therefore, it was concluded that spatial mechanisms may work differently for different aspects of social equity. The implications of these findings are discussed.
Simultaneous Protective Immune Responses of Ducks against Duck Plague and Fowl Cholera by Recombinant Duck Enteritis Virus Vector Expressing Pasteurella multocida OmpH Gene
Authors: Apinda Nisachon , Muenthaisong Anucha , Chomjit Paweena , Sangkakam Kanokwan , Nambooppha Boondarika , Rittipornlertrak Amarin , Koonyosying Pongpisid , Yao Yongxiu , Nair Venugopal , Sthitmatee Nattawooti
Published: August 2022

Duck enteritis virus and Pasteurella multocida are major duck pathogens that induce duck plague and fowl cholera, respectively, in ducks and other waterfowl populations, leading to high levels of morbidity and mortality. Immunization with live attenuated DEV vaccine containing P. multocida outer membrane protein H (OmpH) can provide the most effective protection against these two infectious diseases in ducks. We have recently reported the construction of recombinant DEV expressing P. multocida ompH gene using the CRISPR/Cas9 gene editing strategy with the goal of using it as a bivalent vaccine that can simultaneously protect against both infections. Here we describe the findings of our investigation into the systemic immune responses, potency and clinical protection induced by the two recombinant DEV-ompH vaccine constructs, where one copy each of the ompH gene was inserted into the DEV genome at the UL55-LORF11 and UL44-44.5 intergenic regions, respectively. Our study demonstrated that the insertion of the ompH gene exerted no adverse effect on the DEV parental virus. Moreover, ducklings immunized with the rDEV-ompH-UL55 and rDEV-ompH-UL44 vaccines induced promising levels of P. multocida OmpH-specific as well as DEV-specific antibodies and were completely protected from both diseases. Analysis of the humoral and cellular immunity confirmed the immunogenicity of both recombinant vaccines, which provided strong immune responses against DEV and P. multocida. This study not only provides insights into understanding the immune responses of ducks to recombinant DEV-ompH vaccines but also demonstrates the potential for simultaneous prevention of viral and bacterial infections using viral vectors expressing bacterial immunogens.
Proliferation and Apoptosis of Cat (Felis catus) Male Germ Cells during Breeding and Non-Breeding Seasons
Authors: Valentini Luisa , Zupa Rosa , Pousis Chrysovalentinos , Cuko Rezart , Corriero Aldo
Published: August 2022

The domestic cat (Felis catus) is a seasonal-breeding species whose reproductive period starts when the day length increases. Since the existing information on cat spermatogenesis is limited and somewhat contradictory, in the present study, germ cell proliferation and apoptosis in feral adult tomcats orchiectomized during reproductive (reproductive group, RG; February–July) and non-reproductive (non-reproductive group, NRG; November and December) seasons were compared. Cross-sections taken from the middle third of the left testis were chemically fixed and embedded in paraffin wax. Histological sections were processed for the immunohistochemical detection of proliferating germ cells (PCNA) and for the identification of apoptotic cells (TUNEL method). The percentage of PCNA-positive spermatogonia was higher in the RG than in the NRG. On the contrary, germ cell apoptosis was higher in the NRG than in the RG. Our results confirm that cat spermatogenesis is modulated on a seasonal basis and suggests that spermatogenesis control involves changes in germ cell proliferation and apoptosis according to a common paradigm of seasonally breeding species.
Housing, Instability, and Discrimination amongst Takatāpui/LGBTIQ+ Youth in Aotearoa New Zealand
Authors: Fraser Brodie , Jiang Terence , Cordue Hugo , Pierse Nevil
Published: August 2022

Takatāpui/LGBTIQ+ people’s housing experiences are poorly understood in Aotearoa, New Zealand, including those of young people. We use data from an online survey to investigate experiences of homelessness, involuntary mobility, and housing-related discrimination amongst Takatāpui/LGBTIQ+ youth (n = 334). Multiple linear regression analysis shows a significant relationship between homelessness scores and experience of state care, involuntary mobility, and housing discrimination. Furthermore, these young people had high rates of poverty (57% reporting an annual income below NZD 20,000), involuntary mobility (56%), housing-related discrimination (55%), and lifetime experiences of homelessness (31%). These findings highlight the difficulties that Takatāpui/LGBTIQ+ young people face in the housing market, emphasising the need for targeted programs and policies to meet their needs and prevent homelessness from occurring.
Practical means to forecast potential bankruptcy and financial insolvency of companies
Authors: Alexandrovna-Chernyavskaya Svetlana N , Yuryevna-Roshchektaeva Uliana , Vyacheslavovna-Akasheva Valentina , Ibragimovna-Kitieva Malika , Nikolaevna-Dzodzieva Fatima
Published: August 2022

The actions of companies are a multifaceted and complex procedure. The company communicates with several factors at various levels, from state to the suppliers. At the same time, in the course of the organization's whole operation, both internal and external ever-changing circumstances impact its actions and performance. That kind of ever-changing ambiance places organizations at risk of an financially unstable position. A company's bankruptcy is a regarded as crisis that needs particular approaches of financial management to surmount that. It appears greatly significant to evaluate the status of the company, take steps to restore solvency, and define the likelihood of bankruptcy. Analysis and assessment of the likelihood of bankruptcy supply an overall evaluation of the company's monetary stability, and a prediction for the future. This study aims to analyze some practical means to forecast companies' potential bankruptcy and financial insolvency. To gratify that aim, monographic, economic-statistical, and abstract-logical methods are considered. Based on the results obtained, to raise the effectiveness of the company's capital,  working capital should be normalized through planning the lowest requirement for working capital for all the constituent factors vital for the company’s uninterrupted, and normal operation.
The effect of innovation clusters on investment attractiveness growth in Russia
Authors: Alexandrovna-Chernyavskaya Svetlana , Khasanbievich-Dikinov Andzor , Vladimirovna-Cherner Natalya , Alaudinovna-Ortskhanova Maryam
Published: August 2022

The issue of developing the most efficient approach of funding innovation actions at the present phase of the implementation of cluster policy in the Russia federation is highly important. Exotic direct investments contribute to the triggering the investment procedure in the global economy, indirectly resulting in a rise in sustainability and quality. This study aims to analyze the impact of innovation clusters in the Russian Federation throughout the growth of investment attractiveness and triggering exotic economic integration. The structural, logical, system-functional and comparative analysis are utilized to meet that aim. Given the results, regional investments’ methods on the basis of the cluster means greatly affect investment attractions from huge investors. Nonetheless, investments in individual huge organizations aren’t as constructive as anticipated. It seems completely rational to think that the outcomes of the present shortages of innovation financing are uneven. 2020 was rather challenging for business throughout the globe. The innovative businesses weren’t any exceptions, even though implementing and developing new tools didn’t end and quiche end in some arenas. The investigation of the special literature on the matter under observation permits us to conclude that it is absolutely vital to evaluate the issues of Russian cluster policy and the investment attractiveness of innovative clusters.
La santé des écosystèmes : quelle definition ? / Version en anglais: Ecosystem health : what is the definition ?
Authors: Giraudoux Patrick
Published: August 2022

Ecosystem health is often presented as an emergent property relating to its '' proper functioning''. Following the French Veterinary Academy''s declaration of the 17th of July 2021 on veterinary health, and the Academy’s invitation, this article comments on the notion in the light of ecological knowledge and proposes a definition of ecosystem health : “ The state of diversity or functioning of an ecosystem which, as an ecological unit within a defined space and time, is characterised by its physico-chemical and biological properties, including its robustness and resilience to external stresses. An ecosystem is therefore " healthy" if it preserves the maximum potential of its functions, dynamics and evolutionary capacities, as well as those of the systems it includes and which include it. The various states of possible deficit, or states of health, can be qualified on the basis of an (eco) epidemiological approach, which makes it possible to establish a diagnosis and prognosis, and to propose " therapeutic" paths, as in the medical and veterinary disciplines.” The place of ecosystem health within the concept of “ One Health” is then discussed.
Le vétérinaire face aux nouveaux défis de la filière porcine
Authors: Liber Mélanie , Ridremont Bertrand
Published: August 2022

La France est le 3ème pays producteur de porcs de l’Union Européenne, avec une forte régionalisation de cette production (Grand Ouest). Le modèle d’élevage prédominant est le type «naisseur-engraisseur » . La filière porcine doit relever un certain nombre d’enjeux et répondre à des défis sociétaux croissants : baisse du recours aux antibiotiques et lutte contre l’antibiorésistance, renforcement de la biosécurité, prise en compte croissante du bien-être animal, développement de la médecine de précision avec des outils connectés, respect de l’environnement, attrait du métier d’éleveur. On compte environ 100 à 120 vétérinaires déclarant une activité significative, partielle ou totale, en production porcine. La première mission du vétérinaire spécialisé est le suivi sanitaire des élevages. Face aux enjeux sociétaux actuels, le vétérinaire doit être capable d’accompagner l’éleveur vers des évolutions ou transitions en termes de bien-être animal, biosécurité, prévention, utilisation des données d’élevage et des outils numériques pour contribuer aussi au bien-être de l’éleveur et à la santé économique de l’élevage.
The use of canine models to develop translational gene therapies for the treatment of six forms of inheritedretinal degenerationsb (Work conducted at the University of Pennsylvania-USA)
Authors: Aguirre Gustavo D. , Beltran William A.
Published: August 2022

Identification of genetic mutations responsible for inherited retinal degenerations in a variety of breeds of dogs, coupled with phenotypic characterization of the natural history of disease has provided large animal models that have had a significant impact in translating preclinical discoveries in retinal gene therapies to humans. More than 20 years ago, proof of concept studies conducted in a dog model of childhood blindness led to the first retinal gene therapy to receive market approval in the US and EU. Since this first breakthrough success, vision scientists from the Schools of Veterinary Medicine and Medicine of the University of Pennsylvania have pursued the use of patient-relevant canine models to test and move to the clinic novel retinal gene therapies for five additional diseases.
All-Biobased Hydrovoltaic-Photovoltaic Electricity Generators for All-Weather Energy Harvesting
Authors: Ren Guoping , Hu Qichang , Ye Jie , Hu Andong , Lü Jian , Zhou Shungui
Published: August 2022

Hygroelectricity generators (HEGs) utilize the latent heat stored in environmental moisture for electricity generation, but nevertheless are showing relatively low power densities due to their weak energy harvesting capacities. Inspired by epiphytes that absorb ambient moisture and concurrently capture sunlight for dynamic photosynthesis, we propose herein a scenario of all-biobased hydrovoltaic-photovoltaic electricity generators (HPEGs) that integrate photosystem II (PSII) with
Geobacter sulfurreducens
(
G.s
) for simultaneous energy harvesting from both moisture and sunlight. This proof of concept illustrates that the all-biobased HPEG generates steady hygroelectricity induced by moisture absorption and meanwhile creates a photovoltaic electric field which further strengthens electricity generation under sunlight. Under environmental conditions, the synergic hydrovoltaic-photovoltaic effect in HPEGs has resulted in a continuous output power with a high density of 1.24 W/m
2
, surpassing all HEGs reported hitherto. This work thus provides a feasible strategy for boosting electricity generation via simultaneous energy harvesting from ambient moisture and sunlight.
Some Tautomers of 5-Nitriminotetrazole - A DFT Study
Authors: Türker Lemi
Published: August 2022

Tetrazole compounds having high-nitrogen content, thermal and kinetic stability are usually desired energetic materials. In the present study, various proton tautomers of 5-nitriminotetrazole, including 1,3-types and others, have been investigated within the constraints of density functional theory at the level of B3LYP/6-31++G(d,p). Some structural, spectral, physico chemical and quantum chemical data have been collected and discussed.
PENGARUH PENGGUNAAN MODEL DISCOVERY LEARNING BERBANTUAN LINGKUNGAN TERHADAP KOMPETENSI KEAHLIAN PESERTA DIDIK SMK DALAM PEMBIAKAN TANAMAN
Authors: Darma Rosdiana
Published: August 2022

Pembelajaran biologi di SMK SPP Negeri Samarinda pada peserta didik kelas X ditemukan permasalahan atau kendala (1) rendahnya pencapaian ketuntasan hasil belajar peserta didik, (2) kurangnya keterampilan peserta didik dalam  kompetensi kejuruan pertanian.  Berdasarkan kasus tersebut, salah satu solusi yang dapat dilakukan melalui pengalaman langsung dalam pembelajaran biologi menggunakan model discovery. Supaya peserta didik dapat mudah memahami konsep, dilakukan kegiatan penyelidikan dalam aktivitas pembelajaran yang bermakna. Penelitian ini bertujuan untuk mengetahui efektivitas pembelajaran reproduksi tumbuhan terhadap kompetensi keterampilan peserta didik dalam pembiakan tanaman dengan menggunakan model pembelajaran discovery berbantuan lingkungan. Penelitian ini menggunakan metode eksperimen dengan merujuk pada posttest-only control design, yaitu terdapat dua kelompok yang masing-masing dipilih secara acak (random). Jumlah sampel pada masing-masing kelompok adalah 28 orang. Kelompok pertama merupakan kelompok eksperimen yang akan diberi perlakuan, dan kelompok lain merupakan kontrol. Berdasarkan hasil penelitian dapat disimpulkan bahwa pembelajaran reproduksi tumbuhan dapat meningkatkan aktivitas belajar peserta didik pada kompetensi pengetahuan maupun keterampilan. Selain itu, penggunaan model pembelajaran discovery berbantuan lingkungan dapat  meningkatkan efektivitas pembelajaran, berdasarkan hasil nilai signifikansi (2-tailed) 0,000 0,005 pada independent sample t-test SPSS 20. Pembelajaran reproduksi tumbuhan dapat melatih kompetensi keterampilan peserta didik dalam pembiakan tanaman
VALIDITAS PERANGKAT PRAKTIKUM VIRTUAL TERINTEGRASI MODEL PEMBELAJARAN DISCOVERY LEARNING UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR KRITIS SISWA
Authors: Sidabutar Feronika Romauli , Hasan Ani Mustapa , Nusantari Elya
Published: August 2022

Penelitian ini adalah penelitian pengembangan yang bertujuan untuk menghasilkan perangkat praktikum virtual terintegrasi model pembelajaran Discovery Learning pada materi Bakteri yang memiliki kriteria valid sehingga dapat digunakan dalam proses pembelajaran untuk meningkatkan kemampuan berpikir kritis siswa. Metode yang digunakan dalam penelitian ini yaitu penelitian pengembangan (RD) modifikasi dari Sugiyono (2013). Produk yang dikembangkan adalah Perangkat Praktikum Virtual. RD terdiri dari 10 langkah, tetapi dalam artikel hanya melaporkan 5 tahap sebagai berikut: (1) Potensi dan Masalah; (2) Pengumpulan Data; (3) Desain Produk; (4) Validasi Produk; (5) Revisi Produk. (6) Uji Coba Produk Penelitian ini menggunakan hanya 5 dari 10 langkah dalam model penelitian dan pengembangan (R D) karena menyesuaikan dengan tujuan dari penelitian yang akan diuji. Untuk uji validasi dilakukan dengan mengahadirkan para pakar pada bidangnya yang disebut sebagai validator. Dalam penelitian ini menggunakan 4 validator. Hasil penelitian pengembangan perangkat praktikum virtual  menggunakan aplikasi Adobe photoshop cs 6, kevalidan perangkat praktikum virtual terintegrasi model pembelajaran Discovery Learning telah berkategori sangat valid dengan persentase kevalidan media 87%, persentase kevalidan materi 98,7%, persentase kevalidan perangkat pembelajaran 98% dan persentase kevalidan praktisi 96% dengan kategori sangat valid. Berdasarkan hasil penelitian dapat disimpulkan bahwa perangkat praktikum virtual terintegrasi model pembelajaran Discovery Learning pada materi bakteri sangat valid, untuk meningkatkan kemampuan berpikir kritis siswa
Лечение детей с послеоперационными интраабдоминальными инфильтратами
Authors: Мельниченко М.Г. , Антонюк В.В. , Ситникова В.А. , Элий Л.Б.
Published: August 2022

Цель. Повысить эффективность лечения детей с послеоперационными интраабдоминальными инфильтратами.Материалы и методы. Объектом клинических исследований был аппендикулярный перитонит у 150 детей в возрасте от 2 до 18 лет, находившихся в отделении гнойносептической хирургии Одесской областной детской клинической больницы.Результаты. Разработана программа комплексного лечения послеоперационных интраабдоминальных инфильтратов у детей с аппендикулярным перитонитом путем сочетанного применения медикаментозных и преформированных физических факторов в условиях стационарного и амбулаторного лечения. Доказано, что обнаружение клинических признаков (самостоятельная и спровоцированная боль в животе, пальпируемая «опухоль») свидетельствует о формировании послеоперационного интраабдоминального инфильтрата и его локализации, что требует обязательного комплексного щадящего лечения на всех стадиях возможного аффекта.Выводы. Применение разработанной программы комплексного лечения повысило эффективность лечения и обеспечило хороший результат в 95,1% случаев и отсутствие неудовлетворительного результата.

Purpose. To increase the effectiveness of treatment of children with postoperative intra- abdominal infiltrates.Materials and methods. The object of clinical studies was appendicular peritonitis in 150 children of 2–18 years old, who were in the department of purulent-septic surgery of the Odessa Regional Children’s Clinical Hospital.Results. The program of complex treatment of postoperative intra-abdominal infiltrate in children with appendicular peritonitis by combined use of drug and preformed physical factors under conditions of in-patient and out-patient treatment is developed. It is proved that the detection of clinical signs (independent and provoked abdominal pain, a palpable "tumor") indicates the formation of postoperative intra-abdominal infiltrate and its localization, which requires obligatory comprehensive sparing treatment at all stages of possible affect.Conclusions. The use of the developed program of complex treatment improved effectiveness of treatment and provided a "good" result in 95.1% cases and the absence of an "unsatisfactory" result.
Assessment of the Endourological Surgical Outcomes in Patients with Nonbacterial Inflammatory Sclerosis of the Prostate
Authors: Колца А.Т.
Published: August 2022

Цель. Склероз предстательной железы относится к завершающим стадиям хронического воспалительного процесса предстательной железы (хронический простатит). Эта стадия обычно характеризуется снижением активности воспалительного процесса, при этом железа в значительной степени замещается рубцовой соединительной тканью. У некоторых пациентов склероз предстательной железы может вызвать обструкцию выходного отдела мочевого пузыря. Лечение склероза предстательной железы является актуальной проблемой современной урологии, поскольку оно широко распространено, особенно у мужчин пожилого и старческого возраста.Материалы и методы. В исследование было включено 66 пациентов с нарушениями мочеиспускания, которые получили лечение в урологическом отделении Республиканской клинической больницы им. Тимофея Мошняги. Критерии включения относились к больным, у которых клинически и параклинически подтверждена обструкция инфравезикального оттока, обусловленная хроническим абактериальным простатитом и склеротическими изменениями предстательной железы.Результаты. Полученные результаты лечения свидетельствовали об улучшении показателей International Prostate Symptom Score (IPSS), индекса качества жизни (QoL) и показателей урофлоуметрии через 3 и 6 мес. после оперативного вмешательства. Выводы. Ho:YAG-лазерная резекция предстательной железы является быстрой, безвредной и перспективной операцией при склерозе предстательной железы, в том числе и при рецидиве, применяемом для лечения обструкции инфравезикального оттока.

Purpose. Prostate sclerosis is among the final stages of the chronic inflammatory process of the prostate (chronic prostatitis). This stage is usually characterized by a decreased activity of the inflammatory process, whereas the gland is largely replaced by scar connective tissue. In some patients, prostate sclerosis might cause bladder outlet obstruction. The treatment of prostate sclerosis is a significant issue of modern urology since it is widely occurring especially in older and senile men.Materials and methods. Study included 66 patients with urinary disorders, referred to and treated within the urology department of „Timofei Mosneaga" Republican Clinical Hospital. Inclusion criteria referred to the patients who were clinically and paraclinically confirmed to suffer from infravesical outflow obstruction, caused by chronic nonbacterial prostatitis and sclerotic changes of the prostate.Results. The obtained treatment outcomes showed improvement in International Prostate Symptom Score index (IPSS), the quality of life index (QoL) and uroflowmetry parameters, being assessed before and over 3 and 6 months after the surgical intervention.Conclusions. Ho:YAG laser resection of the prostate is a rapid, harmless and promising procedure for prostate sclerosis, including the recurrent one, being used for treatment of infravesical outflow obstruction, which has also proven satisfactory clinical outcomes.
Pharmaceutical Counseling of a Cardiac Patient
Authors: Гавриленко Л.Н. , Кожанова И.Н. , Романова И.С.
Published: August 2022

Пациенты с заболеваниями сердечно-сосудистой системы являются частыми посетителями аптек, при этом фармацевтические работники проводят консультирование таких пациентов в отношении как рецептурных, так и безрецептурных кардиологических препаратов. Наиболее часто обсуждаемыми вопросами являются принципы рациональной фармакотерапии артериальной гипертензии и коррекции гиперлипидемии.

Patients with cardiovascular disease are frequent pharmacists, with pharmacists advising such patients on both prescription and over-the-counter heart medications. The most frequently discussed issues are the principles of rational pharmacotherapy of arterial hypertension and correction of hyperlipidemia.
The Role of Folic Acid in Planning and during Pregnancy
Authors: Конорев М.Р.
Published: August 2022

Статья посвящена роли фолиевой, или птероилглутаминовой, кислоты (витамина Вс) в период преконцепции и беременности. Фолиевая кислота участвует в пуриновом обмене, который и определяет нормальное развитие эмбриона. Тератогенный эффект при дефиците витамина Вс проявляется в нарушении развития нервной трубки. Показано, что последствия дефицита фолиевой кислоты в период беременности проявляются в нарушении физического (замедление роста у детей) и психического развития новорожденных, а также в снижении устойчивости к инфекционным заболеваниям. Витамин Вс также играет важную роль в профилактике возникновения дефектов развития нервной трубки. В связи с большой протективной ролью фолиевой кислоты для формирования здорового генофонда человека является актуальным назначение фолиевой кислоты перед зачатием и в первые 28 дней беременности, когда отмечается наиболее низкое содержание витамина Вс в организме женщины. Рекомендуемая суточная доза фолиевой кислоты в период преконцепции, беременности и лактации составляет 400 мкг в день.На фармацевтическом рынке Республики Беларусь находится лекарственный препарат, содержащий в таблетизированной форме 0,4 мг фолиевой кислоты, производства ОАО «БЗМП». Фолиевая кислота 0,4 мг (BORIMED) – единственный на рынке Беларуси монопрепарат безрецептурного отпуска, рекомендованный ВОЗ в дозе 0,4 мг/сутки в период преконцепции и во время беременности в качестве первичной профилактики врожденных пороков развития нервной трубки новорожденных.

The article is devoted to the role of folic or pteroylglutamic acid (vitamin Bc) during preconception and pregnancy. Folic acid is involved in purine metabolism, which determines the normal development of the embryo. The teratogenic effect, with a deficiency of vitamin Bc, is manifested in a violation of the development of the neural tube. It has been shown that the consequences of folic acid deficiency during pregnancy are manifested in a violation of the physical (growth retardation in children) and mental development of newborns, as well as in a decrease in resistance to infectious diseases. Vitamin Bc also plays an important role in the prevention of neural tube defects. In connection with the large protective role of folic acid for the formation of a healthy human gene pool, it is important to prescribe folic acid before conception and in the first 28 days of pregnancy, when the lowest content of vitamin Bc in a woman’s body is noted. The recommended daily dose of folic acid is 400 mcg/day during preconception, pregnancy and lactation.On the pharmaceutical market of the Republic of Belarus there is a medicinal product containing 0.4 mg of folic acid in tablet form, manufactured by BORIMED. Folic acid 0.4 mg (BORIMED) is the only non-prescription single monodrug on the market of the Republic of Belarus recommended by WHO at a dose of 0.4 mg/day during preconception and pregnancy as a primary prevention of congenital neural tube defects in newborns.
Type II Diabetes Mellitus: Opportunities and Availability of Pharmacotherapy
Authors: Сачек М.М. , Кожанова И.Н. , Романова И.С. , Чак Т.А.
Published: August 2022

В публикации проведен обзор современных возможностей фармакотерапии пациентов с сахарным диабетом (СД) II типа. Выполнен анализ нормативных документов, регламентирующих оказание медицинской помощи данной категории пациентов в Республике Беларусь, а также ограничительных перечней, определяющих обеспечение лекарственными средствами за счет бюджетных средств пациентов в стационарных условиях (Республиканский формуляр лекарственных средств) и пациентов льготных категорий в амбулаторных условиях (Перечень основных лекарственных средств).

The publication provides an overview of modern possibilities of pharmacotherapy. The main focus is on the treatment of patients with diabetes mellitus type II. The analysis of normative documents regulating the provision of medical care to this category of patients in the Republic of Belarus was carried out. Also, restrictive lists that determine the provision of medicines at the expense of budgetary funds to patients in inpatient settings (Republican Medicines Formulary) and beneficiary patients on an outpatient basis (Essential Medicines List) were analyzed.
Glucocorticoids Immunotropic Effects Realization: the Role of Glucocorticoid Receptors, Transport and Regulatory Systems. The Literature Review
Authors: Голюченко О.А. , Осочук С.С.
Published: August 2022

В настоящее время возрастает актуальность изучения тонких молекулярных механизмов реализации иммуномодулирующих эффектов глюкокортикоидов с целью прогнозирования индивидуальных особенностей реагирования на различные внешние воздействия, в том числе инфекции, хронический стресс, а также развития аутоиммунных заболеваний. В обзоре обсуждаются иммунотропные эффекты глюкокортикоидов с учетом факторов регуляции их секреции и механизмы реализации этих эффектов. Особое внимание уделяется роли глюкокортикоидных рецепторов, а также систем транспорта и деградации кортизола. Представлены современные научные данные о структуре, вариабельности и особенностях функционирования глюкокортикоидного рецептора, роли полиморфизма гена глюкокортикоидного рецептора, систем посттрансляционной модификации в многообразии эффектов кортизола. Появление новых данных, касающихся иммунотропных эффектов глюкокортикоидных гормонов, обосновывает проведение дальнейших исследований, направленных на выявление экспрессии полиморфных генов с целью более глубокой персонализации профилактических и лечебных мероприятий.

Currently, the topicality of studying of the fine molecular mechanisms of glucocorticoids immunomodulatory effects is increasing in order to predict the individual features of the response to various external influences, including infections, chronic stress, and the development of autoimmune diseases. The review discusses the immunotropic effects of glucocorticoids, taking into account the factors regulating their secretion, and the mechanisms of these effects. Particular attention is paid to the glucocorticoid receptors role, as well as the systems of cortisol transport and degradation. Modern scientific data on the structure, variability and features of the glucocorticoid receptor functioning are presented, as well as on the role of glucocorticoid receptor gene polymorphism and post- translational modification systems in the variety of cortisol effects. The emergence of new data regarding the immunotropic effects of glucocorticoid hormones justifies further research aimed at identifying the expression of polymorphic genes in order to deeper personalization of preventive and therapeutic measures.
Relationship between Occupation and Mother's Knowledge of Toddler Development and Stunting at Dabun Gelang Health Center, Dabun Gelang District, Gayo Luwes Regency in 2021
Authors: Sari Maya , Dewi Cut Sari
Published: August 2022

Malnutrition occurs since the baby is in the womb and in the early days of birth, but stunting only appears after the child is 2 years old (Kemenkeu, 2018). Children who experience stunting can experience impaired physical, mental, cognitive and intellectual development so that children are not able to learn optimally. Stunting children have low cognitive abilities, if not treated before reaching the age of five years, they can have an impact until adulthood and are at risk of death and will give birth to children with low birth weight (Soetjiningsih, 2013). The purpose of this study was to determine the relationship between mother's knowledge and work regarding the growth and development of toddlers with the incidence of stunting at the Dabun Gelang Health Center, Dabun Gelang District, Gayo Luwes Regency in 2021. The type of research conducted is descriptive analytical, the population in the study is 578 people and a sample of 57 people is taken, using Accidental Sampling. The data collected in the study is primary data, namely data obtained directly from respondents. The data analysis used is univariate analysis and bivariate analysis. The results of the study were that the majority of respondents lacked knowledge as many as 31 (54.4%) respondents with short stunting, 23 (40.3%%) respondents. From the results of statistical tests obtained P value of 0.003 <0.05, which means that there is a relationship between mother's knowledge about growth and development of toddlers with stunting. the majority do not work as many as 30 (52.6%) respondents with short 25 (43.8%) respondents. From the statistical test results obtained P value 0.000 <0.05, which means that there is a relationship between the mother's work on the growth and development of children under five with the incidence of stunting. It is hoped that health workers at the Dabun Gelang Health Center can encourage and foster the community to better maintain health and improve the growth and development of toddlers so as to minimize the risk of stunting