bluuebunny/crossref_metadata_2025 huggingface dataset:
A randomised, crossover study establishing pharmacokinetic and pharmacodynamic equivalence between Lupin’s Pegfilgrastim and Neulasta® in healthy subjects
Authors: Doctor Shardul , Kasibhatta Ravi , Bob Manoj , Kshirasagar Santhosh , Deoghare Shashank , Bakhle Dhananjay , Shah Chirag
Published: August 2022

Aim This study aimed to demonstrate biosimilarity between Lupin’s
Pegfilgrastim versus Neulasta with respect to
pharmacokinetic (PK), pharmacodynamic (PD), immunogenicity, and safety
profiles. Methods This double-blind, randomised, single-dose,
two-sequence, two-treatment, two-period, crossover, comparative PK and
PD study enrolled healthy subjects aged 18 to 45 years. The test product
was Lupin’s Pegfilgrastim and the reference product was U.S.-licensed
Neulasta. Blood samples were collected at different
time points for assessment of PK, PD, and immunogenicity. Primary
objectives included comparing the relative bioavailability and the
pharmacodynamic effect of the two products. Secondary objectives
included assessing immunogenicity, safety and tolerability.
Biosimilarity was concluded if the 90% confidence interval (CI) of the
ratio of the geometric least-squares mean (LSM) for PK and PD parameters
were within 80 to 125%. Results The geometric mean ratios of Lupin’s
Pegfilgrastim and Neulasta for primary PK parameters
were C [94.37 (89.53 to 99.47%)],
AUC [94.76 (89.83 to 99.95%)] and
AUC [94.82 (89.90 to 100.02%)], and for primary
PD parameters were ANC_C [100.59
(98.96-102.25%)] and ANC_AUEC [100.51
(99.18,101.85%)]. The corresponding 90% CIs were within the
pre-defined equivalence limit of 80% and 125%. The incidence of ADA
formation was similar between patients receiving Lupin’s Pegfilgrastim
and Neulasta. No new safety concerns were observed.
Conclusion This study establishes biosimilarity of Lupin’s Pegfilgrastim
and Neulasta with respect to PK and PD profiles. No
clinically meaningful differences were observed between the biosimilar
and the reference product in terms of immunogenicity, safety, and
tolerability profiles.
Does Globalization Matter for Inflation in Pakistan? Empirical Evidence from Global Slack Hypothesis
Authors: Khan Mukhtiar , Ali Wajid , Khan Asmat
Published: August 2022

This paper aims to evaluate the global slack hypothesis as well as to examine the impact of economic openness on the inflation trend and short-run Phillips curve. For this purpose, the study utilized the Auto Regressive Distributive Lag (ARDL) model to investigate how different measures of openness and global factors (global output and inflation) affect inflation over the period 1970 to 2018. In addition, we also investigate the effect of political regimes (1 for autocracy and 0 for democracy) on inflation and its various proxies in Pakistan. Unlike the existing work that has been done in Pakistan, this study has analyzed the global implications directly for inflation as well as the global slack hypothesis. Results indicate that trade openness is inflationary while financial sector development and the broad measure of openness which is the KOF index have had the opposite effect which might suggest the importance of other dimensions of globalization than trade only. One important finding is that the world output shock and world inflation directly transmit to Pakistan price inflation and in this sense, global factors along with economic openness have some association with inflation. The inclusion of political dummy variable has weaker explanatory power with negative sign maintaining that prudent macroeconomic policy during military regimes keep the inflation level lower. The empirical findings also suggest that although, the global slack hypothesis is validated its impact is not increasing over time. However, comparatively the global slack has dominated the domestic slack and in this sense, its importance has increased over time. Consequently, the process of globalization has important implications for inflation and its dynamics in Pakistan.
Revisiting the Missing Theories of Organizational Justice
Authors:   Assistant Professor in Management Sciences, Kohat University of Science & Technology, Kohat, Pakistan., Shah Ahmed Ullah , Chishti Anwar F. ,   Professor, City University of Science & Technology, Peshawar, Pakistan., Khattak Zeeshan Zeb ,   Associate Professor in Management Sciences, Kohat University of Science & Technology, Kohat, Pakistan.
Published: August 2022

Organizational justice (OJ) literature focuses on the well-established theories of OJ dimensions (distributive, procedural, interpersonal, and informational justices) and the relative significance of different OJ dimensions on dependent variables (Ambrose & Schminke, 2009). However, literature suggest an equal focus on relevant missing theories of justice to have a complete understanding of this concept. The researchers assume that the inclusion of relevant missing theories in their respective OJ dimensions would yield better results. They used two data sets to test this assumption. One data set, include well-established theories using Colquitt (2001) scale, while the second data set include well-established theories along with the relevant missing theories, such as, external equity, equality, and need etc. They concluded that with the incorporation of relevant missing theories in their respective OJ dimensions; overall, results improved in terms of diagnostic statistics including specifically t-statistics (p-values), F-statistics and R2; however, missing theories claim has not been substantiated.
Are Book-Tax Differences Mispriced?
Authors: Hepfer Bradford F.
Published: August 2022

I examine whether book-tax differences (BTDs) are mispriced. I predict that BTD mispricing is the operating cash flows-to-price (CFO/P) anomaly in disguise. Using both time-series asset pricing tests and cross-sectional returns tests, I provide consistent evidence that returns to trading on BTDs are explained by CFO/P. Rather than being an independent anomaly, the findings indicate that any evidence of BTD mispricing is subsumed by the broader CFO/P anomaly. These findings stand in contrast to many studies that infer BTDs possess unique information for future earnings reflected in stock prices with a delay.

JEL Classifications: G12; G14; M41
Range of Risk Factor Levels, Risk Control, and Temporal Trends for Nephropathy and End-stage Kidney Disease in Patients With Type 1 and Type 2 Diabetes
Authors: Halminen Janita , Sattar Naveed , Rawshani Araz , Eliasson Björn , Eeg-Olofsson Katarina , Bhatt Deepak L. , Rawshani Aidin
Published: August 2022

OBJECTIVE

To investigate trends, optimal levels for cardiometabolic risk factors, and multifactorial risk control in diabetic nephropathy and end-stage kidney disease (ESKD) in patients with diabetes and matched control subjects.

RESEARCH DESIGN AND METHODS

This study included 701,622 patients with diabetes from the Swedish National Diabetes Register and 2,738,137 control subjects. Trends were analyzed with standardized incidence rates. Cox regression was used to assess excess risk, optimal risk factor levels, and risk according to the number of risk factors, in diabetes.

RESULTS

ESKD incidence among patients with and without diabetes initially declined until 2007 and increased thereafter, whereas diabetic nephropathy decreased throughout follow-up. In patients with diabetes, baseline values for glycated hemoglobin, systolic blood pressure (SBP), triglycerides, and BMI were associated with outcomes. Hazard ratio (HR) for ESKD for patients with type 2 diabetes who had all included risk factors at target was 1.60 (95% CI 1.49–1.71) compared with control subjects and for patients with type 1 diabetes 6.10 (95% CI 4.69–7.93). Risk for outcomes increased in a stepwise fashion for each risk factor not at target. Excess risk for ESKD in type 2 diabetes showed a HR of 2.32 (95% CI 2.30–2.35) and in type 1 diabetes 10.92 (95% CI 10.15–11.75), compared with control.

CONCLUSIONS

Incidence of diabetic nephropathy has declined substantially, whereas ESKD incidence has increased. Traditional and modifiable risk factors below target levels were associated with lower risks for outcomes, particularly notable for the causal risk factors of SBP and HbA1c, with potential implications for care.
Trends in prescribing preferences for antidiabetic medications among type 2 diabetes patients in the UK with and without chronic kidney disease, 2006-2020
Authors: Liaw Julia , Harhay Meera , Setoguchi Soko , Gerhard Tobias , Dave Chintan
Published: August 2022

  

OBJECTIVES: To evaluate trends in antidiabetic medication initiation patterns among type-2 diabetes mellitus (T2DM) patients with and without chronic kidney disease (CKD). 

RESEARCH DESIGN AND METHODS: Retrospective cohort study using the UK Clinical Practice Research Datalink (2006-2020) was conducted to evaluate the overall, first- and second line (after metformin) medication initiation patterns among CKD (N=38,622) and non-CKD (N=230,963) patients with T2DM.  

RESULTS: Relative to other glucose-lowering therapies, metformin initiations declined overall, but remained the treatment of choice as first-line therapy for both CKD and non-CKD patients. Sodium-glucose co-transporter-2 (SGLT2i) use increased modestly among CKD patients, but this increase was more pronounced among non-CKD patients; by 2020, non-CKD compared to CKD patients were three (28.5% vs 9.4%) and six (46.3% vs 7.9%) times more likely to initiate SGLT2i overall and as second-line therapy, respectively. Glucagon like peptide 1 receptor agonist (GLP-1RA) use was minimal regardless of CKD status (<5%), while both dipeptidyl peptidase-4 inhibitor (DPP4i) and sulfonylurea use remained high among CKD patients. For instance, by 2020 and among CKD patients, DPP4i and sulfonylureas comprised of 28.3% and 20.6% of all initiations, and 57.4% and 30.3% of second-line initiations, respectively. 

CONCLUSIONS: SGLT2i use increased among T2DM patients, but this increase was largely driven by non-CKD patients. Future work identifying barriers associated with the uptake of therapies with proven cardiorenal benefits (e.g., SGLT2i, GLP-1RA) among CKD patients is needed.
Measurement of Serum N-Glycans in the Assessment of Early Vascular Aging (Arterial Stiffness) in Adults with Type 1 Diabetes
Authors: Llauradó Gemma , Amigó Núria , Fuertes-Martín Rocío , Romero Ana , Cano Albert , Albert Lara , Giménez-Palop Olga , Berlanga Eugenio , Fernández-Veledo Sonia , Correig Xavier , Vendrell Joan , González-Clemente José-Miguel
Published: August 2022

  

OBJECTIVE: Vascular aging (arterial stiffness, AS) is an inflammation-linked process that predicts macro- and microvascular complications in adults with type 1 diabetes (T1D). We evaluated the utility of measuring the inflammation-linked N-glycans GlycA and GlycB to assess vascular aging in adults with T1D.

RESEARCH DESIGN AND METHODS: Eighty-four adults with T1D (>10-year duration without cardiovascular events) and 68 healthy controls were evaluated for clinical characteristics (including microvascular complications in patients with T1D), aortic pulse wave velocity (aPWV, surrogate measure of AS), and serum GlycA and GycB (peak area [concentration] and height/width [H/W] ratio) using 1H-NMR spectroscopy.

RESULTS: Patients with T1D had higher median (IQR) values than healthy controls for (P<0.001 for all comparisons): aPWV (7.9 [6.9–9.1] vs. 6.1 [5.5–6.7] m/s), GlycA (850.4 [781.3–916.1] vs. 652.4 [581.5–727.1] µmoL) and GlycB (386.1 [353.2–426.3] vs. 310.0 [280.5–331.9] µmol/L), and H/W ratios for GlycA (16.5 [14.9–18.1] vs. 15.0 [13.7–16.7]) and GlycB (5.0 [4.6–5.5] vs. 4.0 [3.4–4.3]). Moreover, aPWV correlated (P<0.001 for all correlations) with GlycA (r=0.550) and GlycB (r=0.423) concentrations and with H/W ratios of GlycA (r=0.453) and GlycB (r=0.510). Adjusting for potential confounders, GlycA concentration (beta=0.212, P<0.001) and the H/W ratios of GlycA (beta=0.150, P=0.009) and GlycB (beta=0.155, P=0.011) remained independently associated with aPWV. C-statistics for detecting individuals with aPWV >10 m/s were 0.866 (95%CI, 0.794–0.937) for GlycA levels and 0.862 (95%CI, 0.780–0.943) for GlycB H/W ratio. 

CONCLUSIONS: Measurement of serum GlycA/B may have utility in assessing vascular aging in adults with T1D of >10-year duration and no previous cardiovascular events. 
Sujeitos de Direito Internacional Público e o Indivíduo/pessoa natural
Authors: Guimarães Antônio Márcio da Cunha
Published: August 2022

Neste breve trabalho estudaremos quais são os sujeitos de Direito Internacional Público, largamente aceitos pela doutrina atual, e se o Indivíduo - a Pessoa Natural, poderia também ser assim considerado em seus direitos e deveres no âmbito internacional público. Não resta nenhuma dúvida que o Homem, ou seja, o indivíduo enquanto pessoa física é protagonista de relações internacionais no âmbito privado. Analisaremos, portanto, se também o é no âmbito público.
Entre a hipossuficiência e a hipoeficiência
Authors: Santos Rafael
Published: August 2022

Avaliar a eficiência da legislação consumerista em processos de integração pode alavancar a competitividade e o desenvolvimento dos países. Fato é que no Mercosul a falta de sintonia dos parceiros econômicos forma uma barreira não-tarifária ao livre comércio. Isto se deve a adoção da hipossuficiência do consumidor como paradigma de harmonização, modelo que parece confundir hipossuficiência com vulnerabilidade. A análise reforça a argumentação de que a harmonização das leis consumeristas é a alternativa mais eficiente para o bloco, e que, todavia, o emprego da hipossuficiência como paradigma não é adequado à harmonização.
Aplicação dos Incoterms 2020 nos Contratos Internacionais
Authors: Ruiz Costa Juliana
Published: August 2022

O presente artigo traz um estudo sobre os Incoterms, em especial sua mais nova edição de 2020, bem como sua aplicabilidade aos contratos internacionais. O artigo busca analisar os diversos instrumentos que visam facilitar a aplicação dos Incoterms e as técnicas de redação contratual que fazem com que a aplicação destas regras nos contratos internacionais seja mais efetiva. Também busca analisar os métodos aplicáveis para que estes instrumentos sejam melhor utilizados pelos operadores do direito internacional.
Impact of Ayurveda Based Ischemia Reversal Program (IRP) And Polyherbal Medication on Reduction of Resting Myocardial Ischemia with Speckle Tracking Global Longitudinal Strain Imaging in Type 2 Diabetes Mellitus Patients
Authors: Sane, MD Rohit , Manohar Pramod , Mandole Rahul , Amin Gurudatta , Ghadigaonkar Pravin , Dongre Snehal , Yanshwantrao Prafull , Patil Dinesh , Jadhav Rahul
Published: August 2022

Background: Type 2 Diabetes mellitus (T2DM) is a major public health problem with hyperglycaemia leading to ischemia and myocardial damage. Two-dimensional speckle-tracking global longitudinal strain (GLS) imaging is one of the non-invasive tools used for early onset detection of left ventricular systolic dysfunction (LVSD) which goes undetected in the traditionally used tools. The standard of care provided to diabetic patients leads to several adverse effects leading to non-compliance and higher incidences of mortality and morbidity. The current study aimed to evaluate the efficacy of alternative treatment (Ischemia Reversal Program and diet kit) in improving GLS score in T2DM patients. Methodology: This retrospective study was conducted from January 2020 to January 2021 in T2DM patients who attended the Cardiac Care Clinics, Mumbai. The patients underwent 14 sittings of IRP and calorie-controlled diet kit for 30 days. Change in GLS score from baseline formed the primary endpoint while the secondary endpoint were reduction in Body Mass Index (BMI), Abdominal girth (ABG), End diastolic volume (EDV)and dependency of modern medicines and outcome of 6 meter walk test (6MWT). Results: A total of 26 T2DM patients were enrolled with a mean age of 59 years. The GLS score (p=0.0004) and distance covered post 6MWT (p=0.03) showed a significant improvement post IRP treatment. There was a reduction in blood sugar levels and improvement in the cardiac parameters; the difference being not significant. Conclusion: IRP may be an effective and sustainable addition to standard treatment of T2DM and IHD though future large-scale studies are warranted.
EKSISTENSI PENDIDIKAN ISLAM DALAM UPAYA PENURUNAN TINGKAT KRIMINALITAS PADA DAERAH RAWAN KRIMINAL DI LAMPUNG TIMUR
Authors: Hasanah Uswatun , Masitoh Dewi , Khasanah Uswatun , Akmansyah Muhammad
Published: August 2022

East Lampung as one of the crime-prone areas has shown a very rapid decline in crime rates in the last three years, followed by an increase in community enthusiasm and participation in Islamic education. This study aims to determine the extent of Islamic education in reducing crime rates in crime-prone areas in East Lampung. The research method used is descriptive qualitative with a case study approach by selecting the four most crime-prone areas in East Lampung. The sources of data of this research are several religious counselors, local religious leaders, and the surrounding community by selecting samples by purposively using the interview as the main instrument, observation and documentation as secondary intrument. The results of the study found out that East Lampung experienced a drastic reduction in the crime rate due to the development of Islamic informal education, namely Majlis Taklim, Qur’anic schools, Madrasah Diniyah and Islamic Boarding Schools that encourage the drastic changes in attitudes and behavior to be more religious and better. Besides, that able to strengthen community relations and can be a medium for various conflict resolutions between residents so that crime rates can be optimally reduced and the quality of social life in the community can be continually optimized.Keywords: Islamic Education, Criminalism, Crime-Prone Areas
Pengaruh Model GDL terhadap Keterampilan Bertanya dan Kemampuan Pemecahan Masalah Matematika SD
Authors: Loliyana Loliyana , Septianti Ferrenita , Efendi Ujang
Published: August 2022

Masalah penelitian ini adalah keterampilan bertanya dan kemampuan pemecahan masalah matematika peserta didik kelas V SD Negeri 6 Gedong Air masih rendah. Tujuan penelitian ialah untuk mengetahui apakah ada pengaruh model pembelajaran guided discovery learning terhadap keterampilan bertanya dan kemampuan pemecahan masalah matematika peserta didik kelas V SD Negerib6 Gedong Air. Metode penelitian yang digunakan adalah metode pre-eksperimental design menggunakan bentuk one-group pretest-posttest design. Populasi berjumlah 70 orang. Teknik pengambilan sampel menggunakan teknik purposive sampling. Sampel yang digunakan berjumlah 36 orang. Pengumpulan data menggunakan teknik tes dan non tes. Hasil analisis data menunjukkan ada pengaruh model pembelajaran guided discovery learning terhadap keterampilan bertanya peserta didik kelas V SD Negeri, ada pengaruh model pembelajaran guided discovery learning terhadap kemampuan pemecahan masalah matematika peserta didik kelas V SD Negeri, dan ada pengaruh model pembelajaran guided discovery learning terhadap keterampilan bertanya dan kemampuan pemecahan masalah matematika peserta didik kelas V SD Negeri 6 Gedong Air Bandar Lampung tahun ajaran 2019/2020
Scholarly communication at the present stage of development: The example of the journal “Far Eastern Studies” in coverage of the Chinese issues (1972–2022)
Authors: Ostrovskii A. V.
Published: August 2022

The article discusses the history of the journal “Far Eastern Studies” as a leading academic publication created to cover the problems of modern China. Each stage of formation and development of the journal is characterized in detail, as well as the influence on scientific communication of changes in the Soviet-Chinese and Russian-Chinese relations. Difficulties of both objective and subjective nature, which Russian sinologists are faced with at the present stage – related to the digitalization of work and current foreign policy problems– are outlined and possible ways of their solution are indicated.
COPE Flowcharts and infographics – Changes in authorship. Addition of extra author – after publication
Authors: Editorial Article
Published: August 2022

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COPE Flowcharts and infographics – Ghost, guest, or gift authorship in a submitted manuscript
Authors: Editorial Article
Published: August 2022

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COPE Flowcharts and infographics – Undisclosed conflict of interest in a submitted manuscript
Authors: Editorial Article
Published: August 2022

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COPE Flowcharts and infographics – Undisclosed conflict of interest in a published article
Authors: Editorial Article
Published: August 2022

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COPE Council. COPE Discussion document: Predatory publishing. Version 1. November 2019
Authors: Editorial Article
Published: August 2022

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COPE Flowcharts and infographics – Reviewer suspected to have appropriated an author’s ideas or data
Authors: Editorial Article
Published: August 2022

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EFEKTIVITAS PEMBELAJARAN REMEDIAL DALAM MENINGKATKAN HASIL BELAJAR PESERTA DIDIK PADA MATA PELAJARAN IPS DI MTs NEGERI 1 PALU
Authors: N. Samani Moh. Israwan , Pettalongi Adawiyah , Nur Rizka Fadliah
Published: August 2022

This article discusses the effectiveness of remedial learning in improving student learning outcomes in social studies subjects at MTs Negeri 1 Palu. The focus of the discussion in this study is how the effectiveness of remedial learning in improving student learning outcomes in social studies subjects at MTs Negeri 1 Palu and what factors hinder Remedial Learning in improving student learning outcomes in social studies subjects at MTs Negeri 1 Palu. The method that the author uses in this study is a qualitative research method. With data collection techniques including observation, interviews, and documentation. The results of this study indicate that in the effectiveness of remedial learning in improving student learning outcomes in social studies subjects at MTs Negeri 1 Palu, namely efforts to improve students are carried out if these students have not reached the minimum standard value, then students will be given remedial. because in this remedial learning students only repeat material that is not understood. Then the inhibiting factors in the effectiveness of remedial learning in improving student learning outcomes in social studies subjects at MTs Negeri 1 Palu, namely, the lack of attention from students, limited learning time carried out in schools as a result of the pandemic that is still endemic and the lack of communication between teachers and students. students to the problem of improving the value and efficiency of remedial learning in schools.
Fractional Differential Equations in the Exploration of Geological and Mineral Construction
Authors: Wang Yuan , Gao Quanjie
Published: August 2022

As the geological exploration data is relatively sparse, unevenly distributed, and contains many geological faults, simple geological surface reconstruction has certain limitations. Based on the fractional differential equations, the paper establishes a subsidence prediction model in exploring geological and mineral resources. The dynamic system described by the reaction-diffusion equation can be mapped to a nonlinear cellular network through space and time discretization. At the same time, the original partial differential equations can be transformed into ordinary differential equations. Furthermore, we can use the difference method to simulate its evolutionary behavior quantitatively. The research results show that the error accuracy between the prediction results of the fractional gray theory established in this paper and the actual engineering results is higher.
Impact of Air Pollution on Maize and Wheat Production
Authors: Chen Haorui , Zeng Wenzhi , Li Jiuying , Ma Tao , Liu Shenzhou , Lei Guoqing , Gaiser Thomas , Srivastava Amit Kumar
Published: August 2022

To determine the effects of air pollution on crop yields, weather, air pollution, and maize and winter wheat yield data from 331 cities in China from 2014 to 2016 were collected and analysed. Furthermore, support vector regression and the crop growth model were applied to extrapolate the air pollution data of Beijing and Hetian and verify the relationship between air pollution and yield. Precisely, heavy air pollution usually occurred in North China, but less than moderate air pollution levels affected crop yields statistically insignificantly. Moreover, both the winter wheat and maize yields increased in moderate air pollution periods but decreased in heavy air pollution periods in 2014, 2015 and 2016. Importantly, a threshold value was necessary for the heavy air pollution periods to trigger a yield decrease. The threshold values of maize in 2015 and 2016 were 7 days and 5 days, respectively, while that of winter wheat was 10 days in both 2015 and 2016. Once the heavy air pollution periods exceeded the threshold value, both the winter wheat and maize yields decreased linearly with the periods. PM2.5 was the main air pollutant in Beijing in 2014, while PM2.5 and PM10 were the main air pollutants in Hetian in both 2015 and 2016. Regardless of whether the main air pollutant was PM2.5 or PM10, the simulated potential winter wheat yields by the crop growth model with moderate air pollution for the whole growth period were all higher than the yields under observed and heavy air pollution conditions.
Comparative Study of Distance Learning Innovations of Islamic Religious Education Teachers in Aceh Jaya
Authors: Hasan Khairuddin , Anam Khairul
Published: August 2022

This study aims to compare distance learning innovations carried out by Islamic Religious Education teachers in madrasahs and schools. The innovations compared are based on five aspects of Roger's theory, namely; relative advantage, compatibility, testability, observability, and complexity. The research method used is a comparative study with a quantitative approach. Data was collected using a Likert Scale questionnaire that used four levels of choice. The data obtained from the field were analyzed objectively. The data analysis technique used Mann-Whitney U as a non-parametric test. This analysis technique was chosen because the data were not normally distributed. The results of the hypothesis test show that there is no difference in innovation in terms of relative advantage, compatibility, testability, and observability because of the Asymp.Sig 2 tailed score is greater than 0.05. Asymp.Sig score on relative advantage 0.768. Asymp.Sig scores on compatibility 0.170. Asymp.Sig scores on testability 0.215. Score on observability 0.173. The difference in innovation is only in the aspect of complexity with a score of Asymp.Sig 2 tailed 0.007 0.05. The study found that the innovations carried out by the two groups of Islamic Religious Education teachers were relatively the same, only differing in one aspect, namely complexity
Modernization of Islamic Education in North Sumatra: Thoughts and Contributions of Sheikh Ali Hasan Ahmad Ad-Dary
Authors: Nasution Fauziah
Published: August 2022

This research is a figure study research, the purpose is to produce a formulation of analysis of the biography, thoughts, and contributions of Sheikh Ali Hasan regarding the modernization of Islamic education in North Sumatra.  The primary data source of this research is the intellectual works of Sheikh Ali Hasan Ahmad Ad-dary in the form of books, as well as the Islamic education institutions that were developed.  The secondary sources of this research are the works of other people about him. The research stages include data collection, data verification, interpretation, and preparation of research reports on character studies. The data analysis used is content analysis. The research findings show that the educational modernization of Sheikh Sheikh Ali Hasan Ahmad Ad-dary's includes: developing a culture of literacy by producing forty-four written works covering the fields of Fiqh and Islamic Law, Hadith studies, Al-Quran studies, morals and theology, and even actual Islamic issues. In addition, he also pioneered the study of Hadith in North Sumatra and pioneered and developed higher education institutions in North Sumatra. The thought, role, and contribution of Sheikh Ali Hasan Ahmad Ad-dary in the modernization of Islamic education in North Sumatra is a historical fact that cannot be denied until now. Therefore, the study of "modernization of Islamic education carried out by Sheikh Ali Hasan Ahmad Ad-Dary in North Sumatra is very important to do, to find the relevance and contextualization of his thoughts in the present context
The Improvement of Discipline and Professional Fiqh Teachers by Supervisors in Islamic Junior High School
Authors: Zainuddin Zainuddin , Azizah Azizah , Nur Muhammad
Published: August 2022

The aim of this research was to determine the effectiveness of the supervision of the madrasa supervisors in improving the discipline and professionalism of Islamic Jurisprudence teachers at State MTsN in East Aceh Regency. The problem of this research is how the implementation of supervision of madrasa supervisors in improving the discipline and professionalism of Islamic Jurisprudence teachers at State MTsN in East Aceh Regency, what are the supporting and inhibiting factors, and what solutions are taken to overcome these obstacles? This research used a qualitative approach, located at five MTsN in East Aceh Regency, by interviewing three madrasa supervisors, five MTsN principals, and eight Islamic Jurisprudence teachers. The results showed that the implementation of supervision of madrasa supervisor in improving the discipline and professionalism of Islamic Jurisprudence teachers at MTsN in East Aceh Regency begins with planning, supervision of learning administration, and the learning process. The results have had a positive impact on improving the discipline and professionalism of Islamic Jurisprudence teachers. The supporting factors are the enthusiasm to serve for the advancement of teachers and Islamic schools; the enthusiasm to see the discipline and professionalism of Islamic Jurisprudence teachers; support from the leadership; and good cooperation from madrasa principals. The inhibiting factors are the large number of the assisted madrasa, the lack of supervisors, the long distance to the school, and even to inland areas. The solution is to propose a new supervisor, arrange for the distribution of the assisted madrasa for each supervisor not too far away, and encourage teachers and madrasa principals to be willing to become supervisors.
Relationship Between Religion and Science: Analysis of Darussalam Gontor University Response to Covid-19
Authors: Sufratman Sufratman , Awaludin Asep , Herianti Herianti
Published: August 2022

This paper aims to analyze the nature of the relationship between religion and science applied by UNIDA Gontor, especially the policy in dealing with the Covid-19 pandemic. This is done, at least for two reasons. First, UNIDA Gontor is the only higher education institution in the country that continues to carry out normal activities in the midst of the Covid-19 pandemic. Second, UNIDA Gontor is an Islamic educational institution based on Islamic boarding schools. As library research, this paper uses a descriptive method. The results can be concluded that there are at least four patterns in building the relationship between religion and science: conflict, independence, dialogue, and integration. UNIDA Gontor uses an Integration model with the Islamization of knowledge in dealing with the Covid-19 pandemic. This is because UNIDA Gontor applies ihktiar al-diniyyah and al-ilmiyyah at the same time preventing the spread of Covid-19 infection. The two pledges were integrated within the framework of an Islamic worldview, thus, giving rise to three forms of strategic policies, namely; First, form a Covid-19 task force; second, involve elements of the government and IKPM Gontor; and the third, self-isolation. By consistently implementing these efforts, the entire academic community and students in the UNIDA Gontor environment can avoid and function normally even in the midst of the Covid-19 virus infection
Farāʾid Alfāẓ An-nābaāt fī al-Qurʾān al-Karīm: Dirāsaẗ fī al-‘iʿjāz al-Luġhowiy Wā At-Tarbiyah Al-Islaamiyah
Authors: Alawadi Elsayed Mohamed Salem , Ibrahim Kamal Abdel Aziz , Mahdi Rijal , Amin Irsal
Published: August 2022

This research is reveal the secrecy of the plant's sentences in the Qur'an, both specific and general aspects as it has not been previously revealed. This in-depth study in uncovering this uniqueness presents beauty because it is not repeated, and has root words so that it can be seen clearly the beauty of the presentation and arranged according to the context of the study is a clear linguistic system for those who understand. In addition to this linguistic beauty, the usefulness of this study also has meaning from the philosophical aspect of living life which can be used as a life lesson in the form of the value of life. This research is descriptive phenomenological research that uses an integrative approach and linguistic analysis by combining historical methods that explore phenomena both from the aspect of the word origin and the depth of meaning from the philosophical aspect of education. This research consists of two parts, namely the linguistic and philosophical aspects of Islamic education. From the linguistic aspect, there are three studies, namely the definition of linguistic and idiomatic characteristics, critical and rhetorical inheritance, and the uniqueness of plants in the Qur'an. Meanwhile, from the philosophical aspect of education, it is to explore the beauty of God's creation and make it an example in human life that provides many benefits to the surrounding environment. The results of the study conclude that ‎the study of plants in the Qur'an has diverse characteristics which are extremely beautiful in enriching language ‎scholarship and having a philosophical value from the living ways of plants that ‎ give benefits. The Qur'an has many unique characteristics, both historically and in contemporary reality. One of the uniqueness is the linguistic and rhetorical aspects of the word plant. The development of plants that provide many benefits to the surrounding nature can be imitated by humans as intelligent beings.
Congenital diaphragmatic hernia of late presentation: case report
Authors: Bertollo Luiza , Lemos Lucas , Louzada Leticia , Volpini Letícia , Oliveira Elaine , Pinasco Gustavo , Almeida Patricia
Published: August 2022

Congenital diaphragmatic hernia (CDH) is characterized by a closure defect in the diaphragm. Many patients’ present signs and symptoms at birth, but late manifestation may occur, making a difficult diagnosis due to a variable clinical condition. Surgery is necessary and the prognosis in the late presentation is favorable when compared to the early manifestation. We will report a case of a male infant, 7 months and 24 days old, with a history of recurrent dyspnea for 15 days, crying a lot, groaning and constipated. After chest radiography and confirmed by chest tomography, the presence of diaphragmatic hernia was confirmed. The surgery was performed and the patient was released after 7 days of hospitalization. In the face of an unusual late diagnosis, it is expected that such information corroborates the importance of the early diagnosis of CDH.
Osteoporosis and laryngeal involvement secondary to juvenile idiopathic arthritis: case report
Authors: Oliveira Rayana , Nau Angélica , Assmann Rafaela , Bandeira Marcia
Published: August 2022

OBJECTIVE: Juvenile idiopathic arthritis (JIA) is a systemic inflammatory condition and the most common chronic rheumatological disease in childhood. Among complications, patients may have osteoporosis induced by treatment with glucocorticoids or the evolution of the disease. Another rare complication is the involvement of laryngeal cartilage, which may present with stridor or respiratory failure. The purpose of this report is to present a case of JIA with osteoporosis and laryngeal manifestations. CASE REPORT: Female, 15 years old, diagnosed with JIA 12 years ago with irregular treatment that evolved with severe and limiting disease. The patient had stridor and dyspnoea. Laryngoscopy showed involvement of arytenoid cartilage requiring tracheostomy. In addition, the patient was diagnosed with osteoporosis and bilateral coxarthrosis, requiring bilateral total hip arthroplasty.
Instrumentos de avaliação da cultura e clima de segurança do paciente: Revisão narrativa
Authors: Barboza Ana Raquel Campos de Almeida , Domingues Josivane Maria , Souza Charliana Oliveira , Flurh Jackeline da Silva Vargas , Jesus Elizabete Silva Dantas de , Rocha Paula Taciana Soares da , Rocha Aurora Tatiana Soares da , Moraes Andréa Ovando , Mascarenhas Débora Emiko Aoki , Rorato Camila
Published: August 2022

Objetivo: Descrever os instrumentos avaliativos da cultura e de clima de segurança que utilizados em pesquisas nas instituições de saúde. Revisão Bibliográfica: Internacionalmente e no contexto brasileiro, os instrumentos de medidas de segurança foram desenvolvidos e estão sendo cada vez mais utilizados para entender as organizações de saúde, a fim de assegurar uma melhor qualidade na assistência prestada ao paciente. Estes instrumentos permitem a avaliação da cultura e clima de segurança do paciente no tanto no contexto hospitalar, na Atenção Primária a Saúde e no serviço especializado, cabendo ao pesquisador selecionar a melhor ferramenta para o seu estudo. Considerações Finais: A aplicação dos instrumentos de avaliação da cultura e do clima de segurança do paciente pode contribuir para a segurança do paciente dentro das instituições de saúde. Para isso, é necessário que estimule discussão sobre as potencialidades e fragilidades revelando quaisquer diferenças na percepção entre os grupos de profissionais da área da saúde, ajudando a entender como a cultura de segurança influencia no trabalho em saúde e pode facilitar na proposta de intervenções estratégicas para a melhoria do cuidado.
Evaluation of prognostic preoperative factors in patients undergoing surgery for spinal metastases: Results in a consecutive series of 81 cases
Authors: Dobran Mauro , Lisi Serena Vittoria , Di Rienzo Alessandro , Carrassi Erika , Capece Mara , Dorato Pasquale , di Somma Lucia Giovanna Maria , Iacoangeli Maurizio
Published: August 2022

Background:

Surgical treatment of spinal metastases should be tailored to provide pain control, neurological deficit improvement, and vertebral stability with low operative morbidity and mortality. The aim of this study was to analyze the predictive value of some preoperative factors on overall survival in patients undergoing surgery for spinal metastases.

Methods:

We retrospectively analyzed a consecutive series of 81 patients who underwent surgery for spinal metastases from 2015 and 2021 in the Clinic of Neurosurgery of Ancona (Italy). Data regarding patients’ baseline characteristics, preoperative Karnofsky Performance Status Score (KPS), and Frankel classification grading system, histology of primary tumor, Tokuhashi revised and Tomita scores, Spine Instability Neoplastic Score, and Epidural Spinal Cord Compression Classification were collected. We also evaluated the interval time between the diagnosis of the primary tumor and the onset of spinal metastasis, the type of surgery, the administration of adjuvant therapy, postoperative pain and Frankel grade, and complications after surgery. The relationship between patients’ overall survival and predictive preoperative factors was analyzed by the Kaplan–Meier method. For the univariate and multivariate analysis, the log-rank test and Cox regression model were used. P ≤ 0.05 was considered as statistically significant.

Results:

After surgery, the median survival time was 13 months. In our series, the histology of the primary tumor (P < 0.001), the Tomita (P < 0.001) and the Tokuhashi revised scores (P < 0.001), the preoperative KPS (P < 0.001), the adjuvant therapy (P < 0.001), the postoperative Frankel grade (P < 0.001), and the postoperative pain improvement (P < 0.001) were significantly related to overall survival in the univariate analysis. In the multivariate analysis, the Tomita (P < 0.001), Tokuhashi revised scores (P < 0.001), and the adjuvant therapy were confirmed as independent prognostic factors.

Conclusion:

These data suggest that patients with limited extension of primitive tumor and responsive to the adjuvant therapy are the best candidates for surgery with better outcome.
Selection criteria for patch angioplasty material in carotid endarterectomy
Authors: Suroto Nur Setiawan , Rantam Fedik Abdul , Al Fauzi Asra , Widiyanti Prihartini , Turchan Agus , Pangaribuan Vega
Published: August 2022

Background:

Carotid endarterectomy (CEA) with patch angioplasty has been favored due to its lower reoccurrence of restenosis compared to primary CEA. There are multiple types of patch angioplasty material available. However, selection of patch material is based on uncertain criteria. The aim of this study is to determine the ideal criteria for selecting the best patch material for CEA.

Methods:

We conducted a comprehensive literature search for studies that describe the ideal criteria for selecting patch material for CEA. We compiled all of the criteria mentioned into one table and selecting the criteria which were most frequently mentioned with a simple scoring system.

Results:

A total of 65 studies out of 784 studies were assessed for its full-text eligibility. Thus, we found 23 studies that were eligible for analysis. There are 22 ideal criteria that were mentioned in the analyzed studies. We grouped these criteria into physical characteristics, safety, contribution to hemodynamic, contribution in tissue healing, economic aspect, and ability to prevent postsurgical complication. We proposed 10 ideal criteria for guiding vascular surgeon in selecting the best patch angioplasty material.

Conclusion:

To this day, no material has been discovered which meets all ten criteria. This study’s proposed ideal criteria serve as the foundation for the creation of the best patch angioplasty material.
Nosocomial Elizabethkingia meningoseptica meningitis and bacteremia in a post transsphenoidal hypophysectomy complicated with sagittal sinus thrombosis: A case report
Authors: Balakrishnan Naavin Kumar , Ghani Abdul Rahman Izaini , Hassan Mohamad Hasyizan , Mukmin Laila Ab. , Hassan W. Mohd Nazaruddin W.
Published: August 2022

Background:

Elizabethkingia meningoseptica meningitis is rare and challenging to manage infection. As this infection is always associated with superimposed multidrug-resistant organisms, a combination and prolonged antibiotic treatment are necessary to ensure the complete eradication of infections.

Case Description:

We report successful antibiotic therapies in a patient with E. meningoseptica bacteremia and meningitis complicated with superimposed extreme-drug-resistant Acinetobacter baumannii infection in a patient post transsphenoidal hypophysectomy complicated with central venous thrombosis.

Conclusion:

Antibiotic combination therapy with prolonged duration in those with E. meningoseptica with concomitant multi-resistant organisms is needed. Diagnosing associated prothrombotic risk with the infection and prompt treatment would also be essential.
Cerebrospinal fluid venous fistula: Illustrative case
Authors: Shlobin Nathan A. , Shahrestani Shane , Shabani Saman , Agarwal Nitin , Tan Lee
Published: August 2022

Background:

Spinal cerebrospinal fluid (CSF) venous fistulas are an under-recognized cause for spontaneous intracranial hypotension (SIH) which may result in postural headaches.

Case Description:

A 60-year-old-male presented with 6 years of a persistent headache. The initial brain and spine MRIs and conventional CT myelogram (CTM) showed no CSF venous fistula. However, the lateral decubitus dynamic CTM demonstrated a hyperdense paraspinal vein on the right at the T10-11 level consistent with a CSF venous fistula. It was subsequently successfully treated with surgical ligation. Temporary CSF diversion with lumbar drain was required to treat transient rebound intracranial hypertension.

Conclusion:

The diagnosis of a CSF venous fistulas is often missed on standard brain and spine MRI imaging, and conventional CTM. Dynamic CTM is a more effective modality to detect CSF venous fistulas. Surgical ligation is a safe and effective treatment option. Patients with long-standing SIH may encounter rebound intracranial hypertension after CSF venous fistula ligation and may require temporary CSF diversion.
Prediction of the functional and radiological outcome on the basis of independent factors with special emphasis on the use of 3D printed models in craniovertebral junction surgery
Authors: Kataria Rashim , Mehrotra Mudit , Purohit Devendra Kumar , Gupta Ajay , Rathore Monika
Published: August 2022

Background:

The aim of the study was to evaluate the advantage of performing planned surgery using customized three-dimensional (3D) printed models versus performing surgery without using 3D printed models in patients with craniovertebral junction (CVJ) anomalies and traumatic CVJ fractures and dislocations.

Methods:

Forty-two patients with CVJ anomalies, who were planned for operative intervention in the Department of Neurosurgery at SMS Hospital from March 2019 to February 2021, were randomly divided into two groups and analyzed. First group was operated after rehearsal on a customized 3D printed model whereas the second group underwent operative intervention without the rehearsal of surgery on the 3D printed model.

Results:

Forty-two patients were enrolled for the study. Twenty-five of these patients had developmental CVJ anomalies, 16 had post traumatic Atlantoaxial dislocation (AAD), and one had congenital AAD. Twenty-three patients underwent surgical intervention using 3D printed models and 19 without using 3D printed models. The outcome in the two groups was compared using modified Japanese orthopedic association score (mJOA), recovery rate, incidence of complications such as screw malposition, postoperative neurological deterioration, vertebral artery (VA) injury, and radiological improvement based on Atlanto-Dental interval, the distance of the tip of dens from Wackhenheims clivus canal line, and the distance of tip of dens from the Chamberlain’s line. The improvement in mJOA score postoperatively was found to be statistically significant in study group (P < 0.001) as compared to control group (P = 0.06). Recovery rate was better in study group than in control group (P = 0.023). In study group, the incidence of screw malposition and VA injury was lower than control group. Three patients deteriorated neurologically postoperatively in the control group and none in the study group. The average improvements in the radiological parameters were found to be better in study group as compared to control group postoperatively.

Conclusion:

The authors conclude that 3D printed models are extremely helpful in analyzing joints and VA anatomy preoperatively and are helpful in unmasking any abnormal bony and vascular anatomy effectively, making the surgeon confident about the placement of the screws intraoperatively. These 3D models help in intraoperative error minimization with better neurological outcomes in postoperative period. In our opinion, these models should be included as a basic investigation tool in patients of CVJ abnormalities. The models also offer other advantages such as preoperative simulation, teaching modules, and patient education.