bluuebunny/crossref_metadata_2025 huggingface dataset:
STUDY OF THE COMPOSITION OF POLYPHENOL COMPOUNDS IN HERB OF ACHILLEA SETACEA WALDST. ET KIT. AND ACHILLEA SUBMILLEFOLIUM KLOK. ET KRYTZKA
Authors:   Zaporizhia State Medical University, Smoylovska G.P. , Mazulin O.V. ,   Zaporizhia State Medical University, Yerenko O.K. ,   Zaporizhia State Medical University, Maliuhina O.O. ,   Zaporizhia State Medical University, Khortetska T.V. ,   Zaporizhia State Medical University
Published: February 2022

Key words: flavonoids, hydroxycinnamic acids, herb, achillea setacea Waldst. et Kit., a. submillefolium Klok. et Krytzka, HPLC. Plants of the genus achillea L. are rich in polyphenolic compounds, which play an important role in the prevention of chronic diseases, slowing down aging processes as well as reducing the risk of cardiovascular and neurodegenerative diseases. The most studied is the chemical composition of Achillea millefolium, while other plant species growing in Ukraine have not been studied enough. The aim of our work was researching the qualitative and quantitative composition of polyphenolic compounds in the herb of achillea setacea Waldst. et Kit. and a. submillefolium Klok. et Krytzka. Materials and methods. The shredded air-dry raw materials of Achillea submillefolium Klok. et Krytzka and A. setacea Waldst. et Kit. were used for the study. Thin-layer chromatography was used to identify flavonoids and hydroxycoric acids. The method of high-performance liquid chromatography was used to separate the sum of polyphenolic compounds into individual components. Results and discussion. Qualitative identification of flavonoids and hydroxycinnamic substances by TLC revealed the presence of chlorogenic and neochlorogenic acids, luteolin in both species, and rutin in a. setacea Waldst. et Kit. The content of hydroxycinnamic acids and flavonoid compounds were determined by HPLC method. The predominant components are luteolin-7,3’-di-O-β-D- glycoside, neochlorogenic acid, rutin, apigenin-7,4’-di-O- glucopyranoside. The obtained results make to predict the antioxidant, antibacterial and antifungal activity of the extracts of the studied plants.
AUDIT OF PACKAGED PRODUCTS OF MEDICINAL PLANTS FOR TREATMENT OF DIABETES MELLITUS ON THE PHARMACEUTICAL, MARKET OF UKRAINE
Authors:   National University of Health of Ukraine named after PL Shupyk, Kyiv, Vlasenko I. O. , Davtian L. L. ,   National University of Health of Ukraine named after PL Shupyk, Kyiv
Published: February 2022

Key words: marketing, medicinal plants, herbal substances, dietary supplements, pharmacy, diabetes mellitus, pharmaceutical market of Ukraine Phytotherapy is an important part of the treatment of patients with diabetes mellitus. The use of medicinal plants in complex therapy allows to reduce the dose of synthetic drugs, and it can be used as monotherapy. Today pharmacies offer a wide assortimets of medicinal plants. Considering the importance of treatment of diabetes, it is relevant to study the modern market of medicinal plants in Ukraine, which are used for the treatment and prevention of diabetes. The purpose of the work was to audit the assortment of packaged products of medicinal plants for the treatment and prevention of diabetes, which are available on the pharmaceutical market of Ukraine. Materials and methods. The literature data and the official sources of information were the material of the research. We used content analysis, marketing, graphic, comparative and summarizing analyzes. Conclusion. Considering manufacturers, type and packing weight of medicinal plants was found that the number of proposals is 310, while herbal substances, account for 42.3%. Various parts of plants (leaves, flowers, grass, shoots, fruits and so on) are used in phytotherapy for diabetes. The redundancy of assortment of medicinal plants by various domestic manufactures is observed. The herbal substances are packed in corton packs, and dietary supplements are packed in 1.5 g filter bags No. 20. Analysis of Summaries of product characteristics of herbal substances has shown that only part of them have information about therapeutic indication and pharmacological properties for treatment of diabetes. The lack of this information could be a problem for consultation by pharmacist.
THALICTRUM FOETIDUM. ANALYTICAL REVIEW
Authors:   Lviv Polytechnic National University, Lviv, Zhuravel U. , Konechnyi Yu. ,   Lviv National Medical University named after Danylo Halytsky, Lviv, Krvavych A. ,   Lviv Polytechnic National University, Lviv, Konechna R. ,   Lviv Polytechnic National University, Lviv
Published: February 2022

Key words: Thalictrum foetidum, distribution, botanical description, biologically active substances, pharmacological action. The article presents the generalized results of the analysis of literature data on botanical description, distribution area, the content of biologically active compounds, pharmacological activity, and aspects of Thalictrum foetidum use in pharmacy and medicine. Prospects for pharmacognostic and pharmacological studies of the plant are established, based on the results of the analysis.
Comparative analysis of the hemostasis system of cancer patients with thrombotic complications
Authors: Bodnar P. Ya.
Published: February 2022

Surgical treatment of female genital cancer remains a rather difficult task in gynecological practice due to the possibility of thrombotic complications. It is important to study the features of hemostasis in such patients for the practical application of this knowledge. The aim of the study was to scientifically substantiate the features of hemostasis in patients with female genital cancer. Study materials: 103 patients with genital cancer who were treated.

The purpose of the study. Coagulogram, colorimetry, others. Results of the research. As a result of a blood test, it was found that the initial level of hemoglobin in patients with thrombotic complications after surgery decreased by 12%, in patients without thrombotic complications – by 14%. The average platelet count in patients with thrombotic complications decreased by 11,50%, in patients without thrombotic complications – 8,12%. The level of leukocytes in patients with thrombotic complications – increased by 21,05%, in patients without thrombotic complications – 30,30%. In the study of hemostasis, it has been found that surgery in patients with female genital cancer causes a pronounced activation of the hemostasis system, especially in patients with thrombotic complications. In patients with thrombotic complications there is a more pronounced activation of intravascular coagulation on the background of a significant decrease in the level of antigen III than in patients without thrombotic complications. The level of fibrinogen in patients with thrombotic complications in the preoperative period was significantly higher by 16,3% than in patients without thrombotic complications; there was a decrease in fibrinogen levels in the early postoperative period; from the third day after surgery, fibrinogen levels increased in patients without thrombotic complications. There was also a significant reduction in activated partial thromboplastin time in patients with thrombotic complications. The number of soluble complexes of fibrin monomers increased to higher values in patients with thrombotic complications. Conclusion. In the study of hemostasis, it has been found that surgery in patients with female genital cancer causes marked activation of the hemostasis system, especially in patients with thrombotic complications.
Cognitive disorders in patients with nervous system injuries by persistent degrees
Authors: Muravska L. V. , Andreeva O. G. , Dyachenko P. A. , Vasilik V. S. , Klyus V. Yu.
Published: February 2022

Purpose of the study. To study the severity of CP in patients with lesions of the nervous system by persistent pathogens.

Materials and methods of research. Clinicalneurological and neuropsychological research. 53 patients were examined, including 42 (72,24%) women and 11 (20,75%) men. Among them, 32 (60,37%) patients with herpesvirus lesions of the nervous system and tickborne borreliosis (chronic form) – 21 (39,62%). Age of patients – from 19 to 64 years. The control group consisted of 30 people who had no history of herpesvirus lesions of the nervous system and tickborne borreliosis aged 20 to 60 years. According to the involvement of the central and peripheral nervous system in the pathological process, the clinical diagnoses were as follows: arachnoencephalitis, encephalitis, meningoencephalitis in 22 patients (41,5%), arachnoiditis 12 (22.64%), encephalomyelitis 1 (1,88%), diffuse encephalomyelitis 6 (11,32%), arachnoencephalomyelopolyneuropathy 3 (5,66%), encephalopolyneuropathy 5 (9,43%).
The effectiveness of microsurgery for Meniere's disease
Authors: Gusakov A. D. , Skorobogatyi V. V. , Gusakova A. A. , Kokorkin D. N. , Shevluk P. P. , Kolyada N. A.
Published: February 2022

Meniere's disease is a noninflammatory disease, manifested by episodes of dizziness, nystagmus reaction, vegetative disorders, static disturbances, hearing loss, tinnitus. The etiology and pathophysiology of this condition are not fully understood. However, it is based on an increase in endolymph production. To date, a large number of measures have been proposed to prevent the development of dizziness attacks. Starting from lifestyle changes, medical approaches, as well as surgical interventions. But far from always, even a combination of the above methods allows patients to reduce the number of episodes of dizziness, thereby improving the quality of life. At the Department of Otorhinolaryngology of the State Institution «Zaporizhzhya Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine» microsurgical methods of treating this pathology are proposed. The operations of chordoplexusectomy and grommet of the tympanic membrane give a persistent positive clinical effect, which is confirmed in the longterm postoperative period in the observed patients.
New approaches to basic treatment of asthma
Authors: Fushtey I. M. , Savchenko O. A. , Podsevahyna S. L. , Tkachenko A. V. , Myrnyi D. P. , Katsuba J. V.
Published: February 2022

Among chronic respiratory diseases, asthma is one of the most common diseases. The current goal of asthma treatment is to achieve asthmacontrol. Despite the fact that, according to the data of randomized trials, this goal is achievable in most patients, in real clinical practice the proportion of patients who have achieved asthmacontrol does not exceed 42–49%. The article provides an analysis of these recommendations and a literature review of those studies that justify their changes. A key change in the new GINA recommendations is the rejection of shortacting beta2agonists as monotherapy in patients with mild stage I asthma.

The priority regimen of basic therapy at this stage of treatment is now a fixed combination of budesonide/formoterol, taken on demand. Such therapy, according to the literature, was significantlymoreeffectivethanshortactingbeta2 agonists monotherapy. In addition, budesonide/ formoterol is also considered as a priority drug for relieving symptoms on demand, and short acting beta2agonists is currently classified as an alternative drug.

The recommendation is based on the data of randomized trials, in which it was proved that the use of a fixed combination of budesonide/ formoterol on demand, significantly reduces the number of exacerbations of asthma compared with the use of shortacting beta2agonists on demand. The introduction of new GINA recommendations into practice will improve the effectiveness of basic therapy for asthma.
The content of the total protein, protein fractions and blood serum proteins in patients with different forms of lichen ruber planus
Authors: Barannik N. G. , Tsymbaliuk R. Y. , Manukhina O. M. , Sydoryako A. V. , Volchykhina K. P.
Published: February 2022

Purpose of the study. Establishing the role of processes of proteolysis of mixed saliva in the development and course of lichen planus of the oral mucosa.

Materials and methods. A comprehensive examination of 102 patients with lichen planus aged 21 to 70 years and 20 people in the control group, whose age and sex composition corresponded to that in the study group. BioRad (USA) reagent kits were used to determine the total protein content of mixed saliva. The content of protein fractions of mixed saliva was determined by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate. Determination of serum proteins in mixed saliva was performed by quantitative (cross) immunoelectrophoresis.

Results. In patients with lichen planus, the overall proteolytic activity of mixed saliva increases with a significant increase in the concentration of α1proteinase inhibitor, especially in exudative hyperemic and erosiveulcerative forms of the disease. Diffusion of α1proteinase inhibitor into mixed saliva increases its antiproteolytic potential and has a protective character. The content of albumin and ceruloplasmin in the mixed saliva of patients with lichen planus increases depending on the severity of the disease: typical, hyperkeratotic, exudativehyperemic, erosiveulcerative.

Conclusions. Mixed saliva of patients with lichen planus in contrast to patients in the control group is characterized by the predominance of low molecular weight proteins (20–79 kDa) over high molecular weight. The level of albumin, α1proteinase inhibitor and ceruloplasmin in the mixed saliva of patients with lichen planus increases and correlates with the severity of the disease. The content of IgA in the mixed saliva of patients with lichen planus increases, depending on the form of the disease.
COVID19 PANDEMIC AND PREGNANCY
Authors: Prosvyetov Yu. V. , Bessarabov Yu. M. , Barinov S. S. , Gusarova A. Yu.
Published: February 2022

In a COVID19 pandemic, pregnant women become infected no more frequently than the general population. COVID19 in pregnant women is associated with a higher risk of caesarean section. Pregnant women with COVID19 who are obese, have high blood pressure, or a combination of two or more conditions are at risk for more severe disease and longer hospital stays.
Psychopersonal characteristics of women with varying degrees of menopausal disorders
Authors: Lutsenko N. S. , Mazur O. D. , Shapoval O. S. , Zvarich L. I. , Efimenko N. F.
Published: February 2022

The perimenopausal period is the age of the highest spiritual and intellectual development of a woman; therefore, neurovegetative and psycho-emotional disorders of this period acquire a pecial medical and social value and require an interdisciplinary approach.

Purpose of the study. To identify the psychological characteristics of women with mild and moderate menopausal disorders in the perimenopausal period.

Materials and methods. A total of 51 women were examined in the perimenopausal period: I main group – 20 patients with a low degree of CS, II main group – 16 women with menopausal disorders of moderate severity; the control group consisted of 15 healthy women. The severity of menopausal syndrome was determined using a modified menopausal Cooperman's index. All patients underwent psychodiagnostic examination using reactive and personal anxiety scales according to Ch.D. Spielberg and J.L. Hanina, G. Eisenko's test questionnaire, the Women's Sexual Function Index (FSFI) questionnaire, used the SF-36 (Medical Outcomes Study Short Form) general questionnaire to assess quality of life.

Results. In women of the main groups, neurovegetative (14,5 ± 2,6 and 26,6 ± 4,2 points in the first and second groups of observation) and psycho-emotional disorders (4,9 ± 1,3 and 11,2 ± 1,6 points) prevailed. respectively). Hormone levels (FSH, E2, PRL) corresponded to perimenopausal values, but were significantly different from those of the control group. Identified individual-personal properties of women with the CS, in particular introversion and emotional instability. A comparative analysis on the SpielbergKhanin scales showed that more than half (55,0%) in the first main group and the majority (81,25%) of women in the second main group versus 33,35% in the control group (p ˂ 0,05), a high level of personal anxiety was diagnosed; the average level of situational anxiety was highest among women in group II – 54,83 ± 6,0 points versus 43,2 ± 5,3 points in the first group and 36,3 ± 4,8 points in patients without menopausal disorders (p ˂ 0,05). In 24 (77,42%) women of the main group, sexual dysfunction was detected, while its degree was greatest with moderately severe climacteric disorders. Menopausal disorders of varying severity, increased anxiety and neuroticism, sexual dysfunction affected the quality of life of patients.

Conclusion. Formed psychopersonal characteristics of women with varying degrees of menopausal disorders in the perimenopausal period.
Mortality in necrotic form of erysipelas
Authors: Vasylevska L. A.
Published: February 2022

Purpose of the study. To find out the mortality rate in patients with necrotic form of erysipelas and the reasons that cause it.

Materials and metods. 284 case histories of patients who were hospitalized in the center of purulent-septic surgery of KNP «City Hospital

№ 3» in Zaporozhye for the period 2016–2021 were analyzed.

Results. It is established that in the general population of the disease, 14,1% of patients suffer from the necrotic form of erysipelas. In the complex treatment of patients with surgical forms of erysipelas, the main place belongs to antibiotic therapy (ABT) and early surgical treatment of the area of the pathological process. Determination of procalcitonin in blood serum makes it possible to assess the progression of the inflammatory process and is a sensitive test for the effectiveness of treatment.

Conclusion. In 72,5% of cases, the disease was aggravated by sepsis with a mortality of 67,5%. The cause of mortality in patients with necrotic erythema is numerous irreversible changes in the internal organs.
Mitochondrial dysfunction and energy changes of black-substance neurons in experimental parkinson's disease in rats and mothors
Authors: Buchakchyiska N. M. , Belenichev I. F. , Maramukha V. I.
Published: February 2022

Parkinson's disease is a progressive disease with moderate age of the beginning of 55 years. Over time, symptoms worsen, and although levodopa has significantly improved the quality of life of patients with PD, statistics show that these patients continue to show shorter life expectancies compared to the general population. In addition, most patients with PD suffer from significant movement disorders after 5–10 years of illness, even with qualified treatment with available symptomatic drugs.
Spinal anesthesia during foot surgery
Authors: Gritsenko S. N. , Filimonova І. V. , Filimonov R. V.
Published: February 2022

Purpose of the study. To improve the results of treatment of patients with diabetic foot syndrome by substantiating the optimal type of spinal anesthesia during foot surgery.

Materials and methods. 70 patients undergoing treatment in the department of purulent surgery were examined. Patient groups: Group 1 – patients operated on under conditions of unilateral spinal anesthesia; Group 2 – patients operated on under traditional spinal anesthesia.

Research methods. Assessment of the level and intensity of pain, concentration of catecholamines in urine in the first postoperative day, monitoring of blood pressure (BP), heart rate (HR), peripheral blood oxygen saturation (SpO2), Doppler scanning of peripheral blood flow in the foot, skin temperature integument of the foot during anesthesia and statistical.

Results. In group 1, pain sensitivity during movement of the lower limb after anesthesia was 21% less pronounced than in group 2. In group 2, the heart rate decreased by 4,8% during anesthesia. The SpO2 level 20 minutes after the onset of anesthesia decreased in group 2 by 5,1% compared to group 1. The mean arterial pressure in group 2 decreased during anesthesia by 9,9%, in contrast to patients in group 1. After performing anesthesia, systolic blood pressure in the toe increased by 18,3%, and the temperature of the skin on the lateral surface of the leg increased by 3,7%. The concentration of adrenaline in the daily portion of urine in the next postoperative day in group 2 is 35,1% higher than in group 1.

Conclusions. During anesthesia, the blood pressure, heart rate and SpO2 in group 1 did not change in comparison with the initial values (on the operating table before anesthesia). After anesthesia, an improvement in peripheral blood flow in the operated limb was noted. Unilateral spinal anesthesia, in comparison with traditional spinal anesthesia, has a positive effect on the stress response of the patient's body to surgery.
EFFICACY AND SAFETY OF 20% AZELAIC ACID CREAM FOR PAPULO-PUSTULAR ACNE VULGARIS
Authors: Reznichenko N. Yu. , Reznichenko Yu. G. , Reznichenko G. I. , Veretelnyk K. O.
Published: February 2022

Purpose of the study. To determine the safety and efficacy of 20% azelaic acid cream in the treatment of patients with papulopustular acne vulgaris.

Materials and methods. 65 patients with acne vulgaris were examined. The control group consisted of 30 healthy individuals. Acne severity was evaluated according to G. Michaelsson et al. scale, Cook’s scale, absolute number of papules and pustules. Assessment of quality of life was performed. Facial skin microbiocenosis was assessed. All patients with acne vulgaris applied 20% azelaic acid cream during 15 ± 2 days.

Results and discussion. The use of 20% azelaic acid cream contributed to the rapid regression of inflammatory acne. After 10 days of treatment, the number of papulopustular elements decreased in 3 times. After 10 days of therapy acne score according to G. Michaelsson et al. decreased in 1,5 times and after 15 days of treatment – in 1,9 times. After 10 days of therapy the acne score on the Cook’s scale decreased in 1,4 times. At the end of the study the acne score on the Cook’s scale was 2,4 points. There was a significant decrease in the total number of bacteria, the number of coagulase-positive staphylococci, quantity of Propionibacterium acnes on facial skin in 15 days after the start of therapy. A significant difference in the average value of the DLQI was fixed before (18,9 ± 0,31) and at the end (8,1 ± 0,54) of treatment.

Conclusions. The high effectiveness of 20% azelaic acid cream in treatment of papulopustular acne vulgaris was proved. 20% azelaic acid cream provides a rapid regression of inflammatory forms of acne, reduction of total quantity of bacteria and Propionbacterium acnes on skin.
Differential diagnosis of changes in the area of the large duodenal nipple in postcholecystectomy syndrome by the method of parietal impedancemetry
Authors: Veligotsky N. N. , Aleksanian К. А. , Arutyunov S. E. , Shadrin O. V.
Published: February 2022

Purpose of the study. To carry out differential diagnostics of organic and functional changes in the area of the large duodenal papilla (LDP) by the method of parietal impedancemetry in patients with PCES.

Materials and methods. Duodenoscopy with parietal impedance LDP was performed in 47 patients. A history of 38 patients underwent laparoscopic cholecystectomy, and 9 patients underwent laparotomic cholecystectomy. In 31 patients, the study was performed against the background of signs of obstructive jaundice, in 16 – the study was performed against the background of dilatation of the common bile duct without visualization of calculi in it. All patients underwent endoscopic retrograde cholangiopancreatography with determination of parietal impedance prior to endoscopic papillosphincterotomy. The control group consisted of 8 patients without manifestations of PCES, who underwent duodenoscopy with parietal impedancemetry during a routine examination.

Results. The parameters of the parietal impedance of patients with PCES against the background of benign obstructive jaundice in the presence of papillitis were 605–703 Ohm. In the absence of visual signs of inflammation, the resistance of the LDP wall varied within 760–820 Ohm and coincided with the values of the control group.

Conclusion. Parietal impedancemetry is an informative method for detecting inflammatory changes in the LDP, which can be performed routinely during duodenoscopy and allows differential diagnosis between the organic pathology of the LDP zone and its absence.
Pancreatoduodenal resection in the treatment of complicated forms chronic pancreatitis
Authors: Veligotsky N. N. , Arutyunov S. E. , Klymenko M. V. , Veligotsky A. N.
Published: February 2022

Purposeof thestudy. Development ofindications for performing pancreatoduodenal resection in complicated forms of chronic pancreatitis.

Materials and methods. In chronic pancreatitis, resection and drainage surgical interentions were performed in 142 patients. Pancreatoduodenal resection was performed in 13 patients with complicated forms of chronic pancreatitis. To assess the degree of pancreatic fibrosis, ultrasound elastography was used (in mode Shear Wave Elastography). The indications for pancreatoduodenal resection were the presence of a pronounced fibroinflammatory process in the head of the pancreas, the impossibility of excluding the development of an oncological process, developed complications (biliary hypertension, portal hypertension, duodenal stasis,

Results. Among 13 patients with complicated forms of chronic pancreatitis, who underwent pancreatoduodenal resection, 12 (92,3%) patients had severe fibrosis, 1 (7,7%) had minor manifestations of fibrosis. Pancreatoduodenal resection was performed in 2 (15,4%) patients after preliminary biliary decompression, in 2 (15,4%) – after Pjustov-Frey surgery and cystojejunostomy.

Conclusion. Progression of fibroinflammatory changes in the pancreatic parenchyma in chronic pancreatitis, leading to the development of complications (biliary hypertension, duodenal stasis), is an indication for the use of resection surgery.
EFFECT OF DIET AND EXERCISE-INDUCE WEIGHT LOSS ON LEVEL OF RESISTIN IN PATIENT WITH OBESITY
Authors: Tokarenko О. I. , Andreieva I. O. , Tokarenko O. O. , Surmilo M. M.
Published: February 2022

Мета дослідження. Метою цього дослідження було визначити вплив дієти та фізичного навантаження на рівень резистину і оцінити взаємозв'язок резистину зі змінами ваги.

Матеріали та методи. До цього дослідження було включено 133 особи із надмірною вагою/ ожирінням (73 чоловіки та 60 жінок) віком від 29 до 57 років. Кожен пацієнт проходив клінічну оцінку під час консультації (з виміром маси тіла та зростання), біологічні тести. Усі учасники утрималися від будь-якої важкої фізичної активності за 48 годин до вимірювань та були рандомізовані в одну з трьох груп (фізичне навантаження та/або дієта) та контрольну групу.

Результати. Зі 133 пацієнтів у групі фізичного навантаження (ФН) було 39 пацієнтів, 34 суб'єктів – у групі дієтотерапії (Д), 30 – у комплексній групі (ДФН) та 30 – у контрольній групі. Застосування дієти та фізичних вправ сприяло статистично значимим змінам у масі тіла порівняно з контролем. Статистично значущі зміни рівня резистину спостерігалися у пацієнтів із групи ДФН. Статистично значущі зміни у рівні глюкози були зареєстровані у пацієнтів із Д-групи (P < 0,05). Рівні інсуліну (P = 0,076) та резистину (P = 0,137) мали тенденцію до зниження групи ФН, але статистично достовірних відмінностей встановлено не було. Однофакторний регресійний аналіз показав, що зміни резистину були взаємопов'язані зі співвідношенням обсяг талії (ОТ) та обсяг стегна (ОС) та з інсуліном. Регресійний аналіз виявив статистично значущі взаємозв'язки між змінами резистину та інсуліну (r = 0,363, R2 = 0,174, P = 0,038) та співвідношенням ОТ/ОС (r = 0,408, R2 = 0,158, p = 0,018).

Висновки. У пацієнтів із комплексної групи з фізичним навантаженням та дієтотерапією демонстрували статистичне значуще зниження маси тіла, рівня резистину та резистентності до інсуліну. Резистин статистично значно корелює з рівнем інсуліну, але не з індексом HOMA. Регресійний аналіз виявив статистично значущі взаємозв'язки між змінами резистину та інсуліну (r = 0,363, R2 = 0,174, P = 0,038) та співвідношенням ОТ/ОС (r = 0,408, R2 = 0,158, p = 0,018).
Changes in morphofunctional and genetic indicators of ejaculate in men with disorders of reproductive function depending on kind of alcohol drinks consumed
Authors: Vorontsova L. L. , Kozachuk A. S. , Kovalenko V. A.
Published: February 2022

Purpose of the study. Due to the scanty information and the lack of precise data on etiology and pathogenesis of fertility in men consuming alcohol this research was aimed at studying the changes in morphofunctional and genetic parameters of ejaculate in men with impaired ejaculate fertility depending on the type and amount of alcohol consumed

Materials and methods. The article contains the data of researching ejaculate fertile properties and features of spermatozoa DNA fragmentation in 110 men being divided into three groups depending on kind and amount of alcohol consumed.

Results. According to the obtained data the degree of spermatogenesis disorder and tendency to increase level of spermatozoa DNA fragmentation depends on the kind, rate and an amount of alcohol consumed. Thus, the low level in consumption of alcoholic drinks was accompanied by variations of admissible values in spermogram. The most evident changes in ejaculate fertile properties were being observed at middle and high risk in consumption of beer and alcohol mixed, as teratozoospermia has been revealed as a result not only from the ethanol effect but from the impact of components free alcohol character. Revealed tendency of increasing spermatozoa DNA fragmentation level extends our view concerning disorders of ejaculate fertile properties that is obviously connected with alcohol consumption.

Conclusions. Thus, alcohol consumption in great amounts, especially, consuming beer with mixed strong alcohol and also pattern of consuming alcohol as “great doses for short time” contribute to a considerable damage to ejaculate fertile properties.
Diagnostic value of videotoracoscopy in the conditions of antituberculosis institution
Authors: Prosvyetov Yu. V. , Gusarova А. Yu. , Evsa V. A.
Published: February 2022

The article presents the results of diagnostic videothoracoscopy during three years that were performed in an anti-tuberculosis institution. Patients were radiographically discovered to have chest pathology. No bacteria discharge was detected. To verify the diagnosis, 136 patients underwent videothoracoscopy with biopsy.

Evaluation of the obtained biopsy results showed that, only 48 patients (35,3%) had specific tuberculous lesions verified. In other cases, a different pathology was noted: sarcoidosis, oncopathology, nonspecific inflammation, and idiopathic pulmonary fibrosis.

Thus, the results of this study confirmed the high efficiency of the videothoracoscopy method for verifying the diagnosis in patients without bacterial discharge.
VAK-therapy as a variant of local treatment of destructive forms of erysipelas
Authors: Shapoval S. D. , Vasylevska L. A. , Bielinska V. O.
Published: February 2022

Purpose of the study. Improve postoperative treatment of phlegmonous and necrotic forms of erysipelas by alternating HAC therapy of wounds and staged necrectomies, reduce the time of cleaning and preparation of the wound for dermatoplasty.

Materials and metods. The results of treatment of 87 patients with complicated forms of erysipelas who were treated in the purulent-septic center of KNP «City Hospital № 3» in Zaporozhye for the period 2020–2021 were analyzed.

Results. The effectiveness of treatment, including topical therapy, was evaluated by improving laboratory parameters (leukocyte formula), the number of microbial bodies per 1g of tissue and the duration of wound cleansing. In the phlegmonous form of erysipelas, normalization of the leukocyte formula was observed on day 3, which is probably faster than among patients in the control group – on day 4 (t = 4,01375; P = 0,000182). In patients with necrotic form of erysipelas in the main group, the normalization of the leukocyte formula occurred probably faster, almost 2 days, than in the control group – 4 and 6 days, respectively (t = 2,16682; P = 0,042499). At the same time there was a decrease in microbial contamination of wounds. The terms of wound cleansing in the postoperative period in patients of the main group were probably shorter than in patients of the control group – by 1,87 ± 0,23 days in phlegmonous form (t = 3,75213; P = 0,000320) and 2,89 ± 0,34 in necrotic (t = 2,33969; P = 0,026659).

Conclusion. Improvement of postoperative local treatment of patients with phlegmonous and necrotic forms of erysipelas allowed to significantly reduce the length of stay of patients in the hospital by 3,26 ± 0,43 days (t = 6,47461; P < 0,000001).
ANÁLISE DE INFORMAÇÕES NUTRICIONAIS EM RAÇÕES PARA GATOS
Authors: Sousa Lima Antonio Jackson , Boechat Yuri Luiz , Da Cunha Genovez Ligia Mara , Farias Cabral Caio , Rodrigues Silva Lucas Brenno
Published: February 2022

A alimentação dos animais domésticos se torna cada dia mais exigente e balanceada, visando a melhora na qualidade de vida destes animais. Atualmente, existe uma grande variedade de rações para atender esta demanda e facilitar a oferta de alimentos aos animais pelos tutores.  Neste trabalho foram avaliadas as informações nutricionais nos rótulos de rações para felinos domésticos comercializadas na cidade de Bom Jesus- PI e estabelecida a relação preço por quilograma, teor de nutrientes em cada categoria das rações para cada grupo de animais, com o objetivo informativo nutricional e estabelecer uma relação custo-benefício entre as mesmas. Os resultados revelam que há bastante diferença entre as rações, seja da mesma classificação, entre elas e/ou grupos diferentes, tanto em questão de preço, como em quantidade e qualidade de nutrientes. É observado a mesma ração com preços diferentes nas Tabelas 1, 2 e 3, assim como rações da mesma categoria destinada ao mesmo grupo de animais, mas que possuem teores de nutrientes bem distintos. Este estudo ainda leva em conta as rações especiais (Tabela 4) destinadas a animais com problemas urinários, renais e obesos, demostrando a importância da diferença de nutrientes nas rações para essa animais. O que pôde se observar com este trabalho é que a escolha da ração baseada na qualidade e quantidade dos nutrientes é imprescindível para fortalecer e nutrir o animal, além de prevenir ou amenizar problemas de saúde, e que o custo com rações não difere muito mediantes as categorias apresentadas.
CONSUMER BEHAVIOUR DETERMINANTS: EVIDENCE FROM MBA STUDENTS
Authors: Osuagwu Linus
Published: February 2022

The Masters in Business Administration (MBA) programme is a global educational qualification with different forms of values for individuals and organisations and varying degrees of attractions from persons and companies in developed and developing countries. Therefore, many factors motivate individuals and organizations to choose MBA programmes. This research utilised a survey research method, with a research instrument developed from relevant extant literature, to isolate the major factors determining students’ choice behaviour towards MBA programmes in the Nigerian university system. The research reports that the major factors determining students’ choice behavior towards MBA programs include quality-related, information-related, and convenience-related factors. The limitations associated with the research relate to its cross-sectional nature, in addition to the usual limitations associated with the survey research method used in this research. In addition, the combination of MBA students from both private and government-owned universities is likely to pose some limitations. Also, focusing on students from only one country (Nigeria) presents external validity limitations. The research has practical implications for administrators and regulators of business programs in the Nigerian university system, in addition to organizational decision-makers interested in sponsoring their relevant staff for MBA programs in the Nigerian university system. The research has social implications about the different cohorts of students interested in MBA programmes in the Nigerian university system.
Characteristics of intestinal microbiome in children with autism
Authors: Galova, Elena , Shirokova Irina , Blagonravova Anna , Vorobyova Olga , Martusevich Andrew
Published: February 2022

The aim of the study was to assess the prevalence of dysbiosis in children with autism spectrum disorders (ASD). The study was observational, cohort, comparative. All the patients included in it were divided into 2 groups. The first (main) group (n=46) consisted of children aged 4.92±1.57 years with an established diagnosis of ASD. The second (n=20, comparison group) included conditionally healthy children (1 and 2 health groups) aged 5.10±1.16 years, not suffering from ASD. It was stated that in children with autism a reduced content of lactobacilli (p=0.056), the practical absence of lactic acid streptococci (p=0.019), a rarer detection of individual strains of Enterobacter bacteria (Ent. cloacae; p=0.033), an increase of 2 or more times in the frequency in level of hemolytic Escherichia coli (E. coli; p=0.041), some strains of bacteria of the genus Klebsiella (Kl. Рneumoniae; p=0.080) and Citrobacter (Citr. freundii, p=0.015); Staphylococcus aureus (14% vs. 6%, p>0.050) and Candidae fungi (11% vs. 6%, p>0.050) were found more often than in healthy children. In addition, patients with autism have enough level of Bifidobacterium and Escherichia coli. The study showed the presence of shifts in the gut microbiome in children with autism spectrum disorders. At the same time, structure of microbiome differed significantly from that typical for healthy children
Preparation of components of ultrasonic extract of ginkgo biloba, physico-chemical and pharmacological analysis and molecular design
Authors: Kovtun Elena , Pogrebnyak Liudmila , Stepanova Eleonora , Pogrebnyak Andrey , Morozov Yuri , Bokov Dmitry
Published: February 2022

The main task arising during the processing of medicinal plant raw materials is the intensification of extraction processes in order to maximize the extraction of groups of biologically active substances. It is of interest to obtain an extract and conduct molecular modeling in order to predict the biological activity of the components of the ginkgo biloba phytocomplex. The range of dosage forms obtained on the basis of dry extract is small, despite the wide range of pharmacological activity. The aim of the study is to optimize the method of obtaining alcohol extract, with the possibility of including it in various dosage forms. Physico-chemical analysis: Confirmation of the alleged pharmacological activity by the method of molecular modeling. Materials and Methods: Ultrasonic extraction, spectrophotometry in the ultraviolet region. Pharmacological studies by modeling cerebral ischemia using simultaneous bilateral occlusion of the common carotid arteries. Changing the speed of cerebral blood flow by Dopplerography. Results and Discussion. Liquid extract of ginkgo bilobar leaves was obtained by ultrasonic extraction. The calculation of the electronic structure and quantum-chemical descriptors of ginkgolide B. was carried out. The assessment of specific pharmacological activity was carried out. Conclusion: The ultrasonic method of extraction of ginkgo biloba leaves was applied. The predicted biological activity of the obtained phytocomplex was confirmed by methods of molecular modeling and experimentally.
IMPLEMENTASI STANDAR NASIONAL PERPUSTAKAAN DI SMA NEGERI DALAM MENINGKATKAN KUALITAS LAYANAN PENDIDIKAN (STUDI PADA PERPUSTAKAAN SEKOLAH SMAN 3 KOTA MALANG)
Authors: Eko Wahyudi Lestari , Puspaning Galih Aulia , Eko Wismanu Rendra
Published: February 2022

The National Library Standard is the minimum criteria that used as a reference for the organization, management, and development of libraries. Therefore, every library, both public and school library, must have a service standard to maintain and improve their quality, especially improving the quality of education services for school libraries in SMAN 3 Malang. The research aims to describe and analyze the implementation of national library standards in improving the quality of education services at SMAN 3 Malang. The research method used is a qualitative method approach with observation, interviews and documentation data collection techniques. The data analysis used is developed by Robert K. Yin which includes several stages including: compiling, assembling, reassembling, data interpretation, and conclusion. The conclusion of this study shows that SMAN 3 Malang City has tried to manage the library in accordance with the Regulation of National Library of Indonesia Number 12 of 2017 concerning National Standards for high school Libraries which include: collection standards, facilities and infrastructure standards, service standards, library staff standards, and library management standards, although there are still some standards that have not been met due to inadequate quantity and qualification of library staff and budget constraints. In addition, the location of the school library at SMAN 3 Malang which is less strategic is one of the inhibiting factors in meeting these standards. So, the suggestion that can be formulated in this research is the need for collaboration with various stakeholders (private sector) to be able to access CSR (Corporate Social Responsibility) and universities that have library science study programs for collaborative internships and transfer of knowledge as well as assistance in library management in the SMAN 3 Malang library
Giant Lipoma of Hand in a Child: Case Report and Literature Review
Authors: Ramzi Meryam , Assara Nada , Hassani Zakarya Alami , Fellouss Zouhir Alami , Madhi Tariq
Published: February 2022

Although lipomas are the most common benign form of soft tissue tumors that are >5 cm in diameter. They are extremely rare in the hand localization. They are slowly progressive and usually do not cause numbness or weakness of the hand. They can be deceptively large and extensive leading to misdiagnosis. We present here one such case in which symptomatic swelling over sole of right hand was excised and confirmed as a benign lipoma.
Localized Pigmented Villonodular Synovitis in a Child: About a Case
Authors: Ramzi Meryam , Assara Nada , Hassani Zakarya Alami , Fellouss Zouhir Alami , Madhi Tariq
Published: February 2022

Pigmented Villonodular synovitis (PVNS) is a rare benign proliferative condition affecting synovial membranes of joints; it occurs in two forms, localized (LPVNS) and diffuse (DPVNS). We report a case of a 12 years old with LPVNS, confirmed on surgical biopsy. The patient underwent a surgical synovectomy, with good evolution after 1 year follow-up. PVNS is most common in early to middle age, It still exceptional in children. Clinically, its symptology remains aspecefic. This is often a cause of delay in diagnosis. Magnetic resonance imaging (MRI) is the exam of choice. Only a synovial biopsy with histological study confirms the diagnosis; the treatment typically involves surgery: synovectomy, with a risk of recurrence.
The Managements of Surgical Emergencies of Suspected and High-Risk Patients of COVID-19
Authors: Haque Dr. A. S. M. Rezbanul , Nazma Dr. Shamima , Ray Dr. Upendra Nath , Ara Dr. Ismat , Muraduzzaman Dr. , Islam Dr. AKM Zahedul , Rahman Dr. Md. Anisur , Shorower Dr. Md. Golam , Hasan Dr. Md. Sameul
Published: February 2022

Objective: In this study our main goal is to evaluate the managements of surgical emergencies of suspected and high-risk patients of COVID-19. Method: This observational study was conducted at Tertiary medical college and hospital from May 2020 to March 2021. Where 80 COVID-19 suspected patients of both genders with different ages (15- 65) who was admitted to OPD for surgical emergencies. Results: During the study, majority belong to 56-65years age group, 35% and most of them were male, 65%. According to distribution of patients according their emergency conditions, 35% cases were burst appendix, 30% cases perforation gas containing hollow viscus, 25% were Intestinal obstructions. Mean duration of hospital was 6.5±1.2 days and intussusception seen in 5 cases after surgery. Conclusions: In conclusion, the number of emergency surgeries decreased during the pandemic. Perhaps a new algorithm is required for emergencies in these unusual situations.
Accidental Bladder Injury during Elective Repair of a Strangulated Inguinal Hernia: A Preventable Complication with High Morbidity
Authors: Soumeya Dr. Ettahiri , Houda Dr. Ezzaki , Tarik Dr. Souiki , Karim Dr. Ibn Majdoub , Imane Dr. Toughrai , Khalid Dr. Mazaz
Published: February 2022

Urinary bladder injury is usually rare and asymptomatic, and can occur during herniorrhaphy for misdiagnosed sliding hernia. It’s necessary to recognize a iatrogenic injury intra operatively, and institute treatment in the same operative session, Preoperative diagnosis can prevent possible to the bladder and ureter surgery and lead to quick recovery. The radiological examination is needed before any surgery, especially when the patient has concomitant urinary symptoms. If bladder hernia is suspected, we should imperatively perform preoperative radiology including ultrasound cystography, CT scan or MRI. Keeping a bladder catheter in situ can alert the surgeon in the event of bladder surgery.
Post - Excisional Defect of Middle Third of Helix Reconstructed by Antia-Buch Helical Chondrocutaneous Advancement Flap
Authors: Mahipathy Surya Rao Rao Venkata , Durairaj Alagar Raja , Sundaramurthy Narayanamurthy , Jayachandiran Anand Prasath , Rajendran Suresh
Published: February 2022

The Antia-Buch flap is a chondrocutaneous helical advancement flap done as a single stage procedure to reconstruct the helix. Here, we present a 62 year old male patient with basal cell carcinoma of the middle 3rd of the helix of the left pinna. He underwent local excision with a 0.5cm margin and the resulting defect was reconstructed with an Antia-Buch chondrocutaneous helical advancement flap.
Primary Anorectal Malignant Melanoma: Case Report and Review of Literature
Authors: Khenchoul Youcef , Bataiche Abderraouf , Hellal Dounia , Bendjaballah Saadoune
Published: February 2022

Anorectal malignant melanomas are rare and aggressive tumors. The diagnosis is based on pathological exams. We reported the case of a 54 years old patient who underwent a surgical resection for rectal melanomas diagnosed after histological exams of rectal biopsy tissues.
Primary Mantle Cell Lymphoma of Pancreas- Rare Case
Authors: Jonnalagadda Praveen Babu , Subramanian Dr. Sankar , P Dr. Suresh Kumar , Asokan Dr. Chinni Vikram
Published: February 2022

Primary pancreatic lymphomas (PPLs) are rare cancers that have a complicated histological classification. Sufficient sample volumes are required to adequately diagnose and decide the best treatment for PPLs. A 54-year-old man with primary pancreatic mantle cell lymphoma is described in this case study. Percutaneous biopsy was used to extract histological samples. Atypical small to medium round cells predominated in the tumor cells, which had diffuse CD20 and cyclin D1 positivity. Chemotherapy was used on the patient, and he went into complete remission as a result. Because it provides adequate samples for testing, a percutaneous biopsy could be a valuable and safe diagnostic tool for PPLs.