bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatial–Temporal Variation Characteristics of Multiple Meteorological Variables and Vegetation over the Loess Plateau Region
Authors: Zhao Qingzhi , Ma Xiongwei , Liang Liang , Yao Wanqiang
Published: February 2020

Ecological restoration and climate change in the Loess Plateau region have become research hotspots. Climate change and anthropogenic activities have led to spatial–temporal pattern variations in vegetation and extreme climatic indices and meteorological factors. Therefore, obtaining a better understanding is necessary of the internal relations between vegetation and meteorological factors. In this paper, the interplay between vegetation index and various factors, including extreme climatic indices and meteorological factors, during a long-term time series is investigated using Mann–Kendall trend analysis, and Pearson correlation coefficient analysis. The mechanisms of interaction between vegetation growth and various factors in the Loess Plateau are then analyzed. Results reveal that (i) the rapid growth of vegetation during 2000–2015 has made a major contribution to the growth trend of the Loess Plateau in the past 33 years (1982–2015). During 2000–2015, the increase of vegetation may inhibit the increase of extreme warm index and the decrease of extreme cold index; (ii) a warm and dry climate developed with decreasing relative humidity and increasing temperature; (iii) the normalized vegetation index (NDVI) is strongly correlated with extreme climatic indices and meteorological factors, especially precipitable water vapor (PWV), with a correlation coefficient of 0.94; and (iv) the daily temperature range, diurnal temperature range and sunshine duration (SSD) exerted different time-delay effects on vegetation growth in the Loess Plateau. The above findings provide an essential theoretical basis for ecological policy formulation in the Loess Plateau.
Rapid Optical Spin Initialization of a Quantum Dot in the Voigt Geometry Coupled to a Two-Dimensional Semiconductor
Authors: Stefanatos Dionisis , Karanikolas Vasilios , Iliopoulos Nikos , Paspalakis Emmanuel
Published: February 2020

We study the interaction of a quantum dot in the Voigt configuration with a laser pulse and particularly analyze the potential for rapid spin initialization by putting the quantum dot near a molybdenum disulfide (MoS 2 ) monolayer. The MoS 2 monolayer influences the spontaneous decay rates of the quantum dot, leading to anisotropically enhanced decay rates, for the quantum dot’s electric dipole moments parallel and perpendicular to the layer. By solving the relevant density matrix equations, we find that high spin initialization fidelity is obtained at short times. The fidelity is significantly higher than when the quantum dot is in free-space vacuum. We examine two different cases of the interaction of the quantum dot with the applied optical field. First, we use a continuous wave laser field and determine for various quantum dot—MoS 2 layer distances the field strength that leads to acceptable fidelity levels. The effect of the quality of the MoS 2 material on the fidelity of spin initialization is also examined. We also study the interaction of the quantum dot with a laser pulse and apply numerical optimal control to obtain the time-dependent field strength, which leads to maximum final fidelity for short time intervals. The latter approach gives beneficial results in comparison to the continuous wave field excitation.
Range Localization of a Moving Source Based on Synthetic Aperture Beamforming Using a Single Hydrophone in Shallow Water
Authors: Du Jin-Yan , Liu Zong-Wei , Lü Lian-Gang
Published: February 2020

To localize a moving source in shallow water with a single hydrophone, a passive range localization method based on synthetic aperture beamforming is proposed. First, the horizontal wavenumber spectrum excited by the source is obtained by synthetic aperture beamforming. Then, according to the theoretical derivation (when the integration time is short, the maximum value of the horizontal wavenumber spectrum is related to the average horizontal wavenumber and the radial velocity of the source), the radial velocity can be obtained after obtaining the average horizontal wavenumber. Finally, in the case where there is a closest point of approach (CPA), the range can be recovered from estimation of the range and time of CPA, and from the constant source speed alone the linear track by fitting the source velocity with the model of radial velocity. The only a priori information required is the sound velocity in water. The processing results using simulated data and SWellEx-96 experimental data show that the proposed method can effectively estimate the range of a moving source in shallow sea.
Study of the Impact of PV-Thermal and Nanofluids on the Desalination Process by Flashing
Authors: Sami Samuel
Published: February 2020

In this study, a mathematical and numerical modeling of the photovoltaic (PV)-thermal solar system to power the multistage flashing chamber process is presented. The proposed model was established after the mass and energy conservation equations written for finite control volume were integrated with properties of the water and nanofluids. The nanofluids studied and presented herein are Ai2O3, CuO, Fe3O4, and SiO2. The multiple flashing chamber process was studied under various conditions, including different solar radiation levels, brine flows and concentrations, and nanofluid concentrations as well as flashing chamber temperatures and pressures. Solar radiation levels were taken as 500 w/m2, 750 w/m2, 1000 w/m2, and finally, 1200 w/m2. The nanofluid volumetric concentrations considered varied from 1% to 20%. There is clear evidence that the higher the solar radiation, the higher the flashed flow produced. The results also clearly show that irreversibility is reduced by using nanofluid Ai2O3 at higher concentrations of 10% to 20% compared to water as base fluid. The highest irreversibility was experienced when water was used as base fluid and the lowest irreversibility was associated with nanofluid SiO2. The irreversibility increase depends upon the type of nanofluid and its thermodynamic properties. Furthermore, the higher the concentration (e.g., from 10% to 20% of Ai2O3), the higher the availability at the last flashing chamber. However, the availability is progressively reduced at the last flashing chamber. Finally, the predicted results compare well with experimental data published in the literature.
Coupled Stratospheric Chemistry–Meteorology Data Assimilation. Part I: Physical Background and Coupled Modeling Aspects
Authors: Ménard Richard , Chabrillat Simon , Robichaud Alain , de Grandpré Jean , Charron Martin , Rochon Yves , Batchelor Rebecca , Kallaur Alexander , Reszka Mateusz , Kaminski Jacek W.
Published: February 2020

A coupled stratospheric chemistry–meteorology model was developed by combining the Canadian operational weather prediction model Global Environmental Multiscale (GEM) with a comprehensive stratospheric photochemistry model from the Belgian Assimilation System for Chemical ObsErvations (BASCOE). The coupled model was called GEM-BACH for GEM-Belgian Atmospheric CHemistry. The coupling was made across a chemical interface that preserves time-splitting while being modular, allowing GEM to run with or without chemistry. An evaluation of the coupling was performed by comparing the coupled model, refreshed by meteorological analyses every 6 h, against the standard offline chemical transport model (CTM) approach. Results show that the dynamical meteorological consistency between meteorological analysis times far outweighs the error created by the jump resulting from the meteorological analysis increments at regular time intervals, irrespective of whether a 3D-Var or 4D-Var meteorological analysis is used. Arguments in favor of using the same horizontal resolution for chemistry, meteorology, and meteorological and chemical analysis increments are also presented. GEM-BACH forecasts refreshed by meteorological analyses every 6 h were compared against independent measurements of temperature, long-lived species, ozone and water vapor. The comparison showed a relatively good agreement throughout the stratosphere except for an upper-level warm temperature bias and an ozone deficit of nearly 15%. In particular, the coupled model simulation during an ozone hole event gives better ozone concentrations than a 4D-Var chemical assimilation at a lower resolution.
Aqueous-Phase Production of Secondary Organic Aerosols from Oxidation of Dibenzothiophene (DBT)
Authors: Liu Yu , Lu Junchen , Chen Yanfang , Liu Yue , Ye Zhaolian , Ge Xinlei
Published: February 2020

Intermediate-volatility organic compounds (IVOCs) have been recognized as an important contributor to the secondary organic aerosol (SOA) formation via gas-phase reactions. However, it is unclear whether or not IVOCs-SOA can be produced in the aqueous phase. This work investigated aqueous oxidation of one model compound of IVOCs, dibenzothiophene (DBT). Results show that DBT can be degraded by both hydroxyl radical and the triplet excited states of organic light chromophores (3C*). Aqueous dark oxidation of DBT was also possible. SOA yields of 32% and 15% were found for hydroxyl radical (OH)-mediated photo-oxidation and dark oxidation, respectively. A continuous and significant increase of oxidation degree of SOA was observed during OH photo-oxidation, but not during the dark oxidation. Factor analyses revealed that there was a persistent production of highly oxygenated compounds from the less oxygenated species. OH-initiated photochemical reactions can also produce species with a relatively large light-absorbing ability, while such photo-enhancement due to direct light irradiation and 3C*-initiated oxidation could occur, but is much less important. In the future, studies on the second-order rate constants, molecular characterization of the oxidation products from this and other IVOCs precursors are needed to better understand the role of this reaction pathway in SOA budget, air quality and climate change.
Warm Island Effect in the Badain Jaran Desert Lake Group Region Inferred from the Accumulated Temperature
Authors: Liang Xiaoyan , Zhao Liqiang , Niu Zhenmin , Xu Xingbin , Meng Nan , Wang Nai’ang
Published: February 2020

The Badain Jaran Desert (BJD) is characterized by the coexistence of over 110 perennial lakes and thousands of megadunes in its southeast part. Unlike the cold island effect, we found a special phenomenon of the warm island effect in the lake group region of the BJD. However, the concept and formation mechanism remains unclear. In this study, based on observations of land surface processes in the area, we first used the daily mean temperature from 23 automated meteorological stations from 2010 to 2017 to calculate the mean daily temperature (T) ≥ 0 °C, T ≥ 10 °C accumulated temperature and negative accumulated temperature. Furthermore, using the net radiation from two eddy covariance measurement systems, characteristics of the net radiation between the lake and megadunes were analyzed. When comparing observed data in the lake group region to surrounding areas, accumulated temperature from all three meteorological stations in the lake group region were higher; the duration days of T ≥ 0 °C and T ≥ 10 °C were longer, whereas duration days of negative accumulated temperature were shorter. In addition, the initial dates for T ≥ 0 °C and T ≥ 10 °C accumulated temperature were earlier, whereas the end dates were delayed. Variations in heat were observed between stations in the lake group region that may be reflective of microclimate environments between lakes. The authors relate warm island formation in the BJD lake group region to (1) the heat carried by groundwater recharge to the desert lake groups has a great impact on the local temperature. (2) Net heat radiation to the atmosphere through sensible heat flux owing to sparse vegetation in the desert areas. Hence, heat resources are richer in the lake group region. This study aims to improve our understanding of the warm island effect from a comprehensive analysis of its intensity and distribution pattern around the lake group region as compared to its surroundings. In addition, the results from this study will provide a scientific basis for determining the source of lake water in the BJD.
High-Fat Diet Propelled AOM/DSS-Induced Colitis-Associated Colon Cancer Alleviated by Administration of Aster glehni via STAT3 Signaling Pathway
Authors: Jin Bo-Ram , Chung Kyung-Sook , Lee Minho , An Hyo-Jin
Published: February 2020

Many epidemiological observational studies suggest that a high-fat diet (HFD) accelerates the risk of colorectal cancer (CRC). Inflammation can play a key role in the relationship between colon cancer and HFD. Although reported by several studies, controlled experimental studies have not explored this relationship. We established an HFD-fed colitis-associated colon cancer (CAC) mice model and evaluated the anti-tumorigenic effects of AG on HFD-propelled CAC along with its mechanism of action. Previously, we found that Aster glehni (AG) exerts chemopreventive effects on azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CAC in a mice model, and has anti-adipogenic effects in a HFD-induced obesity mice model. In the HFD-propelled CAC mice model, AG significantly reduced cancer-related death, prevented body weight loss, and alleviated splenic enlargement. Additionally, AG prevented colon shortening and reduced the number of colorectal polyps. Histological studies demonstrated the up-regulation of inflammation, hyperplasia, and neoplasia in HFD-propelled CAC mice, whereas AG suppressed colonic disease progression and tumorigenesis. Furthermore, AG significantly inhibited the signal transducer and activator of transcription 3 (STAT3) signaling pathway and attenuated the protein expression of the STAT3 target gene, which mediates transcription factor-dependent tumor cell proliferation. These results indicate that AG abrogates inflammation-induced tumor progression in HFD-propelled CAC mice by inhibiting STAT3 activation.
Structural Determinants Responsible for the Preferential Insertion of Ribonucleotides by Bacterial NHEJ PolDom
Authors: Sánchez-Salvador Alejandro , de Vega Miguel
Published: February 2020

The catalytic active site of the Polymerization Domain (PolDom) of bacterial Ligase D is designed to promote realignments of the primer and template strands and extend mispaired 3′ ends. These features, together with the preferred use of ribonucleotides (NTPs) over deoxynucleotides (dNTPs), allow PolDom to perform efficient double strand break repair by nonhomologous end joining when only a copy of the chromosome is present and the intracellular pool of dNTPs is depleted. Here, we evaluate (i) the role of conserved histidine and serine/threonine residues in NTP insertion, and (ii) the importance in the polymerization reaction of a conserved lysine residue that interacts with the templating nucleotide. To that extent, we have analyzed the biochemical properties of variants at the corresponding His651, Ser768, and Lys606 of Pseudomonas aeruginosa PolDom (Pa-PolDom). The results show that preferential insertion of NMPs is principally due to the histidine that also contributes to the plasticity of the active site to misinsert nucleotides. Additionally, Pa-PolDom Lys606 stabilizes primer dislocations. Finally, we show that the active site of PolDom allows the efficient use of 7,8-dihydro-8-oxo-riboguanosine triphosphate (8oxoGTP) as substrate, a major nucleotide lesion that results from oxidative stress, inserting with the same efficiency both the anti and syn conformations of 8oxoGMP.
Spraying Ozonated Water on Bobal Grapevines: Effect on Wine Quality
Authors: Campayo Ana , Serrano de la Hoz Kortes , García-Martínez M. Mercedes , Salinas M. Rosario , Alonso Gonzalo L.
Published: February 2020

Ozonated water is being introduced as an alternative phytosanitary treatment to control grapevine diseases in a context in which the reduction of chemical pesticides has become an urgent necessity. In this study, we evaluated the effect of spraying grapevines with ozonated water on the enological, phenolic, and aromatic qualities of Bobal wines during two consecutive growing seasons. In the first season, ozonated water was applied once during the ripening period on grapevines trained on the traditional gobelet system (S1). In the second season, three applications were performed between fruit set and harvest on grapevines grown on a vertical trellis system (S2). The S1 treatment led to a wine with an increased alcoholic degree and a remarkably higher phenolic content, which resulted in preferable chromatic characteristics. The S2 treatment maintained the total phenolic content but significantly enhanced stilbenes and flavanols and also reduced anthocyanins, which negatively affected the wine colour. Regarding aroma, both treatments reduced the content of glycosylated precursors and had different effects on free volatiles, both varietal and fermentative. Thus, the metabolic response of grapevines to the ozonated water stress, and therefore the quality of wines, depended on the ozone dose received by the plants.
Structural Changes of Sarco/Endoplasmic Reticulum Ca2+-ATPase Induced by Rutin Arachidonate: A Molecular Dynamics Study
Authors: Rodríguez Yoel , Májeková Magdaléna
Published: February 2020

Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) maintains the level of calcium concentration in cells by pumping calcium ions from the cytoplasm to the lumen while undergoing substantial conformational changes, which can be stabilized or prevented by various compounds. Here we attempted to clarify the molecular mechanism of action of new inhibitor rutin arachidonate, one of the series of the acylated rutin derivatives. We performed molecular dynamics simulations of SERCA1a protein bound to rutin arachidonate positioned in a pure dipalmitoylphosphatidylcholine bilayer membrane. Our study predicted the molecular basis for the binding of rutin arachidonate towards SERCA1a in the vicinity of the binding site of calcium ions and near the location of the well-known inhibitor thapsigargin. The stable hydrogen bond between Glu771 and rutin arachidonate plays a key role in the binding. SERCA1a is kept in the E2 conformation preventing the formation of important salt bridges between the side chains of several residues, primarily Glu90 and Lys297. All in all, the structural changes induced by the binding of rutin arachidonate to SERCA1a may shift proton balance near the titrable residues Glu771 and Glu309 into neutral species, hence preventing the binding of calcium ions to the transmembrane binding sites and thus affecting calcium homeostasis. Our results could lead towards the design of new types of inhibitors, potential drug candidates for cancer treatment, which could be anchored to the transmembrane region of SERCA1a by a lipophilic fatty acid group.
Intracellular Delivery of DNA and Protein by a Novel Cell-Permeable Peptide Derived from DOT1L
Authors: Geng Jingping , Guo Xiangli , Wang Lidan , Nguyen Richard Q. , Wang Fengqin , Liu Changbai , Wang Hu
Published: February 2020

Cellular uptake and intracellular release efficiency of biomacromolecules is low because of hurdles in the cell membrane that result in limited access to intra-cellular targets with few functional effects. Cell-penetrating peptides (CPPs) act as cargo delivery vehicles to promote therapeutic molecule translocation. Here, we describe the novel CPP-Dot1l that not only penetrates by itself, but also mediates cargo translocation in cultured cells, as confirmed by fluorescence microscopy and fluorescence spectrophotometry. We conducted cytotoxicity assays and safety evaluations, and determined peptide-membrane interactions to understand the possible pathway for cargo translocation. Additional nucleic acid and covalently conjugated green fluorescence protein (GFP) studies mediated by CPP-Dot1l were conducted to show functional delivery potential. Results indicate that CPP-Dot1l is a novel and effective CPP due to its good penetrating properties in different cell lines and its ability to enter cells in a concentration-dependent manner. Its penetration efficiency can be prompted by DMSO pretreatment. In addition, not only can it mediate plasmid delivery, but CPP-Dot1l can also deliver GFP protein into cytosol. In conclusion, the findings of this study showed CPP-Dot1l is an attractive pharmaceutical and biochemical tool for future drug, regenerative medicine, cell therapy, gene therapy, and gene editing-based therapy development.
Efficacy of Jackfruit365™ Green Jackfruit Flour Fortified Diet on Pegfilgrastim to Prevent Chemotherapy-Induced Leukopenia, Irrespective of Tumor Type or Drugs Used—A Retrospective Study
Authors: Varughese Thomas , Joseph James , Menon Rejeesh
Published: February 2020

Chemotherapy-Induced Leukopenia (CIL) is associated with increased mortality and economic burden on patients. This study was conducted to evaluate whether inclusion of green jackfruit flour in regular diet of those patients receiving chemotherapy, could prevent CIL. This was a retrospective study conducted among a group of patients undergoing chemotherapy for solid tumors at Renai Medicity Hospital, Palarivattom, Cochin, Kerala, India, since June 2018. The study group comprised of 50 consecutive subjects, who were supplemented with green jackfruit flour diet in their regular diet and further followed up prospectively. The control group was retrospective with 50 subjects prior to June 2018, with no diet supplements. Those who received less than three cycles were excluded from either arm. The mean age of the participants in study group and control group were 53.16 ± 11.06 and 56.96 ± 12.16 years respectively. In the study group, six patients out of 37, and 20 patients out of 50 in the control group, developed CIL. They received 38 and 105 vials of filgrastim respectively. After excluding those cycles in study group patients, where green jackfruit flour was not taken, the mean number of cycles in which CIL developed (p = 0.00) and number of vials of filgrastim taken per cycle (p = 0.00) were significantly different from control group and no patient in the study group developed CIL. Inclusion of green jackfruit flour as a dietary intervention prevents chemotherapy-induced leukopenia in patients undergoing chemotherapy along with pegfilgrastim.
Orientation-Dependent Reflection of Structurally Coloured Butterflies
Authors: Zobl Sigrid , Wilts Bodo D. , Salvenmoser Willi , Pölt Peter , Gebeshuber Ille C. , Schwerte Thorsten
Published: February 2020

The photonic structures of butterfly wing scales are widely known to cause angle-dependent colours by light interference with nanostructures present in the wing scales. Here, we quantify the relevance of the horizontal alignment of the butterfly wing scales on the wing. The orientation-dependent reflection was measured at four different azimuth angles, with a step size of 90°, for ten samples—two of different areas of the same species—of eight butterfly species of three subfamilies at constant angles of illumination and observation. For the observed species with varying optical structures, the wing typically exhibits higher orientation-dependent reflections than the individual scale. We find that the measured anisotropy is caused by the commonly observed grating structures that can be found on all butterfly wing scales, rather than the local photonic structures. Our results show that the technique employed here can be used to quickly evaluate the orientation-dependence of the reflection and hence provide important input for bio-inspired applications, e.g., to identify whether the respective structure is suitable as a template for nano-imprinting techniques.
Screen-Printed Electrodes Modified with Metal Nanoparticles for Small Molecule Sensing
Authors: Antuña-Jiménez Daniel , González-García María Begoña , Hernández-Santos David , Fanjul-Bolado Pablo
Published: February 2020

Recent progress in the field of electroanalysis with metal nanoparticle (NP)-based screen-printed electrodes (SPEs) is discussed, focusing on the methods employed to perform the electrode surface functionalization, and the final application achieved with different types of metallic NPs. The ink mixing approach, electrochemical deposition, and drop casting are the usual methodologies used for SPEs’ modification purposes to obtain nanoparticulated sensing phases with suitable tailor-made functionalities. Among these, applications on inorganic and organic molecule sensing with several NPs of transition metals, bimetallic alloys, and metal oxides should be highlighted.
Dynamical Role of Pivotal Brain Regions in Parkinson Symptomatology Uncovered with Deep Learning
Authors: Nguyen Alex A. , Maia Pedro D. , Gao Xiao , Damasceno Pablo F. , Raj Ashish
Published: February 2020

Background: The release of a broad, longitudinal anatomical dataset by the Parkinson’s Progression Markers Initiative promoted a surge of machine-learning studies aimed at predicting disease onset and progression. However, the excessive number of features used in these models often conceals their relationship to the Parkinsonian symptomatology. Objectives: The aim of this study is two-fold: (i) to predict future motor and cognitive impairments up to four years from brain features acquired at baseline; and (ii) to interpret the role of pivotal brain regions responsible for different symptoms from a neurological viewpoint. Methods: We test several deep-learning neural network configurations, and report our best results obtained with an autoencoder deep-learning model, run on a 5-fold cross-validation set. Comparison with Existing Methods: Our approach improves upon results from standard regression and others. It also includes neuroimaging biomarkers as features. Results: The relative contributions of pivotal brain regions to each impairment change over time, suggesting a dynamical reordering of culprits as the disease progresses. Specifically, the Putamen is initially the most critical region accounting for the overall cognitive state, only being surpassed by the Substantia Nigra in later years. The Pallidum is the first region to influence motor scores, followed by the parahippocampal and ambient gyri, and the anterior orbital gyrus. Conclusions: While the causal link between regional brain atrophy and Parkinson symptomatology is poorly understood, our methods demonstrate that the contributions of pivotal regions to cognitive and motor impairments are more dynamical than generally appreciated.
Flanker Task Performance in Isolated Dystonia (Blepharospasm): A Focus on Sequential Effects
Authors: Pekrul Max , Seer Caroline , Lange Florian , Dressler Dirk , Kopp Bruno
Published: February 2020

Isolated dystonia manifests with involuntary muscle hyperactivity, but the extent of cognitive impairment remains controversial. We examined the executive functions in blepharospasm while accounting for motor symptom-related distractions as a factor often limiting the interpretability of neuropsychological studies in dystonia. Our control group comprised of patients with hemifacial spasm, which is a condition producing similar motor symptoms without any central nervous system pathology. Nineteen patients with blepharospasm and 22 patients with hemifacial spasm completed a flanker task. Stimulus congruency on the current trial, on the preceding trial, and a response sequence served as independent variables. We analyzed the response time and accuracy. Gross overall group differences were not discernible. While congruency, congruency sequence, and response sequence exerted the expected effects, no group differences emerged with regard to these variables. A difference between patients with blepharospasm and those with hemifacial spasm consisted in longer reaction times when responses had to be repeated following stimulus incongruency on the preceding trial. We conclude that patients with blepharospasm seem to have difficulties in repeating their responses when incongruency on preceding trials interferes with habit formation or other forms of fast routes to action. Our specific finding may provide an opportunity to study altered basal ganglia plasticity in focal dystonia.
Behavioral and Electrophysiological Correlates of Performance Monitoring and Development in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder
Authors: Liu Yanni , Hanna Gregory L. , Hanna Barbara S. , Rough Haley E. , Arnold Paul D. , Gehring William J.
Published: February 2020

The pathophysiology of attention-deficit/hyperactivity disorder (ADHD) involves deficits in performance monitoring and adaptive adjustments. Yet, the developmental trajectory and underlying neural correlates of performance monitoring deficits in youth with ADHD remain poorly understood. To address the gap, this study recruited 77 children and adolescents with ADHD and 77 age- and gender-matched healthy controls (HC), ages 8–18 years, who performed an arrow flanker task during electroencephalogram recording. Compared to HC, participants with ADHD responded more slowly and showed larger reaction time variability (RTV) and reduced post-error slowing; they also exhibited reduced error-related negativity (ERN) and error positivity effects, and reduced N2 and P3 congruency effects. Age effects were observed across groups: with increasing age, participants responded faster, with less variability, and with increased post-error slowing. They also exhibited increased ERN effects and increased N2 and P3 congruency effects. Increased RTV and reduced P3 amplitude in incongruent trials were associated with increased ADHD Problems Scale scores on the Child Behavior Checklist across groups. The altered behavioral and ERP responses in ADHD are consistent with the pattern associated with younger age across groups. Further research with a longitudinal design may determine specific aspects of developmental alteration and deficits in ADHD during performance monitoring.
Acute Sleep Curtailment Increases Sweet Taste Preference, Appetite and Food Intake in Healthy Young Adults: A Randomized Crossover Trial
Authors: Tajiri Eri , Yoshimura Eiichi , Hatamoto Yoichi , Shiratsuchi Hideki , Tanaka Shigeho , Shimoda Seiya
Published: February 2020

This study aimed to examine the effect of acute sleep curtailment on sweet taste preference, appetite and food intake, and the correlation between food intake and sweet taste preference or active ghrelin using a randomized crossover design (5 h sleep curtailment vs. 8 h control). Twenty-four participants (11 men) aged 21.4 ± 1.0 years, with BMI 19.8 ± 1.7 kg/m2, who habitually slept 5 h/night or more experienced interventions lasting three consecutive nights. Participants came into the laboratory for testing on day 4. Fasting blood tests were conducted at 8:00 a.m. to measure active ghrelin and leptin levels. Sweet taste preference was assessed by presenting five different concentration sucrose solutions at 9:00 a.m. Ad libitum intake at breakfast was assessed for 30 min from 9:30 a.m. Sweet taste preference was higher following sleep curtailment than control. Active ghrelin was likewise higher following sleep curtailment than control. Leptin did not differ between conditions. Energy intake was higher following sleep curtailment than control, being derived primarily from carbohydrates. However, sweet taste preference and active ghrelin did not correlate with energy intake. These results suggest that acute consecutive sleep curtailment increases sweet taste preference, active ghrelin, and energy intake in healthy young adults.
Children’s Creativity and Personal Adaptation Resources
Authors: Gryazeva-Dobshinskaya Vera G. , Dmitrieva Yulia A. , Korobova Svetlana Yu. , Glukhova Vera A.
Published: February 2020

The study provides insights into the aspects of creativity, the structure of psychometric intelligence, and personal adaptation resources of senior preschool children. Creativity and intelligence are presented as general adaptation resources. Existing studies of creative ability and creativity as integral individual characteristics in the context of adaptation are analyzed. The aim is to identify varied sets of creativity and personal adaptation resource markers that differentiate groups of children in order to determine possible strategies for adaptation, preservation, and development of their creative abilities at the beginning of lyceum schooling. It embraces the use of the E. Torrance Test of Creative Thinking (TTCT) (figural version), the Wechsler Intelligence Scale for Children (WISC), and the G. Rorschach Test. A sample of the study consisted of 122 children, aged 6–7 and enrolled in a school. The average IQ score among the children was above 115 (M = 133.7, σ = 9.9). The entire sample was divided into four groups by the originality-elaboration ratio according to the TTCT. The correctness of the children’s division into the groups according to the markers of creativity and personal adaptation resources is confirmed by the discriminant analysis. We have identified the factor structure of creativity, intelligence, and personal adaptation resources in the entire sample of children and in each of the groups. In the group of preschoolers with high originality and elaboration, the resulting structure integrated the components of creativity with personal adaptation resources and intelligence scores. In the group of children with a low level of originality and elaboration, the markers of creativity, intelligence, and personal adaptation resources are not interlinked.
Prognostic and Predictive Molecular Biomarkers for Colorectal Cancer: Updates and Challenges
Authors: Koncina Eric , Haan Serge , Rauh Stefan , Letellier Elisabeth
Published: February 2020

Colorectal cancer (CRC) is a leading cause of death among cancer patients. This heterogeneous disease is characterized by alterations in multiple molecular pathways throughout its development. Mutations in RAS, along with the mismatch repair gene deficiency, are currently routinely tested in clinics. Such biomarkers provide information for patient risk stratification and for the choice of the best treatment options. Nevertheless, reliable and powerful prognostic markers that can identify “high-risk” CRC patients, who might benefit from adjuvant chemotherapy, in early stages, are currently missing. To bridge this gap, genomic information has increasingly gained interest as a potential method for determining the risk of recurrence. However, due to several limitations of gene-based signatures, these have not yet been clinically implemented. In this review, we describe the different molecular markers in clinical use for CRC, highlight new markers that might become indispensable over the next years, discuss recently developed gene expression-based tests and highlight the challenges in biomarker research.
The Non-Coding RNA Landscape of Plasma Cell Dyscrasias
Authors: Morelli Eugenio , Gullà Annamaria , Rocca Roberta , Federico Cinzia , Raimondi Lavinia , Malvestiti Stefano , Agosti Valter , Rossi Marco , Costa Giosuè , Giavaresi Gianluca , Azab Abdel Kareem , Cagnetta Antonia , Cea Michele , Tagliaferri Pierosandro , Neri Antonino , Munshi Nikhil C. , Viglietto Giuseppe , Tassone Pierfrancesco , Amodio Nicola
Published: February 2020

Despite substantial advancements have been done in the understanding of the pathogenesis of plasma cell (PC) disorders, these malignancies remain hard-to-treat. The discovery and subsequent characterization of non-coding transcripts, which include several members with diverse length and mode of action, has unraveled novel mechanisms of gene expression regulation often malfunctioning in cancer. Increasing evidence indicates that such non-coding molecules also feature in the pathobiology of PC dyscrasias, where they are endowed with strong therapeutic and/or prognostic potential. In this review, we aim to summarize the most relevant findings on the biological and clinical features of the non-coding RNA landscape of malignant PCs, with major focus on multiple myeloma. The most relevant classes of non-coding RNAs will be examined, along with the mechanisms accounting for their dysregulation and the recent strategies used for their targeting in PC dyscrasias. It is hoped these insights may lead to clinical applications of non-coding RNA molecules as biomarkers or therapeutic targets/agents in the near future.
The Effects of Diet and Dietary Interventions on the Quality of Life among Breast Cancer Survivors: A Cross-Sectional Analysis and a Systematic Review of Experimental Studies
Authors: Barchitta Martina , Maugeri Andrea , Magnano San Lio Roberta , Quattrocchi Annalisa , Degrassi Flori , Catalano Francesca , Basile Guido , Agodi Antonella
Published: February 2020

There is an ongoing need for solid evidence about the effects of healthy behaviors, and particularly diet, on the quality of life (QoL) among breast cancer survivors. We first conducted a cross-sectional study on 68 Italian stage I-III breast cancer survivors, to investigate the association of adherence to the Mediterranean diet (MD), physical activity and weight status with QoL. Adherence to MD and physical activity was assessed using structured questionnaires. QoL was assessed using the European Organization for the Research and Treatment of Cancer Quality-of-Life tools. We showed that low consumption of red meat and carbonated beverages, daily consumption of wine and high consumption of dishes seasoned with sofrito had beneficial effects on several QoL subscales. By contrast, using olive oil as the main culinary fat, low consumption of commercial sweets and high consumption of nuts were associated with negative effects. Overall, these findings resulted in a null effect of adherence to MD on QoL. Furthermore, we observed better QoL sub-scores among women who performed moderate physical activity (i.e., diarrhea) and those who were underweight/normal weight (i.e., physical functioning and dyspnea) if compared with their counterparts (p-values ≤ 0.003 after correction for multiple comparison). Next, we performed a systematic review of nine experimental studies to summarize whether dietary interventions might improve QoL among breast cancer patients. All the studies demonstrated significant improvements in overall QoL and/or its subscales after the interventions. However, differences in study design, interventions and tools used for QoL assessment did not allow us to provide an overall estimate. Moreover, only a single-arm trial evaluated the effect of an exclusive dietary-based intervention, while others combined dietary recommendations with physical activity and weight loss programs. For these reasons, our study encourages more efforts to improve the robustness of current evidence, through more homogenous tools, larger population-based studies and further randomized controlled trials.
Oxygen Reduction Reaction Catalyzed by Pt3M (M = 3d Transition Metals) Supported on O-doped Graphene
Authors: Cui Chaonan , Sun Mengnan , Zhu Xinli , Han Jinyu , Wang Hua , Ge Qingfeng
Published: February 2020

Pt3M (M = 3d transition metals) supported on oxygen-doped graphene as an electrocatalyst for oxygen reduction was investigated using the periodic density functional theory-based computational method. The results show that oxygen prefers to adsorb on supported Pt3M in a bridging di-oxygen configuration. Upon reduction, the O–O bond breaks spontaneously and the oxygen adatom next to the metal–graphene interface is hydrogenated, resulting in co-adsorbed O* and OH* species. Water formation was found to be the potential-limiting step on all catalysts. The activity for the oxygen reduction reaction was evaluated against the difference of the oxygen adsorption energy on the Pt site and the M site of Pt3M and the results indicate that the oxygen adsorption energy difference offers an improved prediction of the oxygen reduction activity on these catalysts. Based on the analysis, Pt3Ni supported on oxygen-doped graphene exhibits an enhanced catalytic performance for oxygen reduction over Pt4.
Impregnation of CaO from Eggshell Waste with Magnetite as a Solid Catalyst (Fe3O4/CaO) for Transesterification of Palm Oil Off-Grade
Authors: Helwani Zuchra , Ramli Muliadi , Saputra Edy , Bahruddin Bahruddin , Yolanda Delvi , Fatra Warman , Idroes Ghazi Mauer , Muslem Muslem , Mahlia Teuku Meurah Indra , Idroes Rinaldi
Published: February 2020

In this work, calcium oxide (CaO) extracted from eggshell impregnated with magnetite (Fe3O4) is prepared successfully and it had been applied on transesterification of palm oil off-grade. Prior experiment, the eggshells material are powdered and calcined at 900 °C then impregnated with Fe3O4 and recalcined. The obtained Fe3O4/CaO catalyst is characterized using X-ray diffraction and Braunaeur–Emmet–Teller (BET) surface area. The influence of various parameters including recalcined time and temperature are investigated. The prepared catalyst is tested for transesterification of palm oil off-grade to produce biodiesel in which the optimal conditions of a methanol/palm oil off-grade molar ratio of 10:1, the catalyst weight of 6%, the reaction temperature of 70 °C, and the reaction time of 2 h. The transesterification product was analyzed using GC-MS, which showed the biodiesel yield of 90% at the recalcined temperature of 600 °C and reaction time of 2 h. It has been noted that the catalyst activity is achieved when the moderate recalcination temperature is applied and the disordered structure of the catalyst is maintained. This study also confirms that CaO impregnated with Fe3O4 could be a solid catalyst for the biodiesel synthesis through transesterification reaction of palm oil off-grade.
Nanostructured Equimolar Ceria-Praseodymia for Total Oxidations in Low-O2 Conditions
Authors: Sartoretti Enrico , Martini Fabio , Piumetti Marco , Bensaid Samir , Russo Nunzio , Fino Debora
Published: February 2020

A Gasoline Particulate Filter (GPF) can be an effective solution to abate the particulate matter produced in modern direct injection gasoline engines. The regeneration of this system is critical, since it occurs in oxygen deficiency, but it can be promoted by placing an appropriate catalyst on the filter walls. In this paper, a nanostructured equimolar ceria-praseodymia catalyst, obtained via hydrothermal synthesis, was characterized with complementary techniques (XRD, N2-physisorption, FESEM, XPS, Temperature Programmed Reduction, etc.) and its catalytic performances were investigated in low oxygen availability. Pr-doping significantly affected ceria structure and morphology, and the weakening of the cerium–oxygen bond associated to Pr insertion resulted in a high reducibility. The catalytic activity was explored considering different reactions, namely CO oxidation, ethylene and propylene total oxidation, and soot combustion. Thanks to its capability of releasing active oxygen species, ceria-praseodymia exhibited a remarkable activity and CO2-selectivity at low oxygen concentrations, proving to be a promising catalyst for coated GPFs.
2D Mesoporous Channels of PMO; a Platform for Cluster-Like Pt Synthesis and Catalytic Activity in Nitrophenol Reduction
Authors: Esmat Mohamed , Mohtasham Hamed , GadelHak Yasser , Mehrebani Reza Tarbiat , Tahawy Rafat , Rostamnia Sadegh , Fukata Naoki , Khaksar Samad , Doustkhah Esmail
Published: February 2020

Thiourea-bridged organosiloxane is used to synthesize a periodic mesoporous organosilica (PMO). Since this PMO has an S-enriched surface, owing to thiourea functional groups, it exhibits strong coordination toward Pt ions, and it shows a high tunability in the Pt nanoparticles size. This hybrid mesoporous material is employed as a catalyst in the efficient reduction reaction of 4-nitrophenol to 4-aminophenol at room temperature in an aqueous media.
Degradation of Carbamazepine by Photo(electro)catalysis on Nanostructured TiO2 Meshes: Transformation Products and Reaction Pathways
Authors: Franz Silvia , Falletta Ermelinda , Arab Hamed , Murgolo Sapia , Bestetti Massimiliano , Mascolo Giuseppe
Published: February 2020

Carbamazepine (CBZ) is a pharmaceutical compound recalcitrant to conventional wastewater treatment plants and widely detected in wastewater bodies. In the present study, advanced oxidation processes for carbamazepine removal are investigated, with particular regard to the degradation pathways of carbamazepine by photoelectrocatalysis and conventional photocatalysis. Photoelectrocatalysis was carried out onto TiO2 meshes obtained by Plasma Electrolytic Oxidation, a well-known technique in the field of industrial surface treatments, in view of an easy scale-up of the process. By photoelectrocatalysis, 99% of carbamazepine was removed in 55 min while only 65% removal was achieved by photolysis. The investigation of the transformation products (TPs) was carried out by means of UPLC-QTOF/MS/MS. Several new TPs were identified and accordingly reaction pathways were proposed. Above 80 min the transformation products disappear, probably forming organic acids of low-molecular weight as final degradation products. The results demonstrated that photoelectrocatalysis onto TiO2 meshes obtained by plasma electrolytic oxidation is a useful alternative to common advanced oxidation processes as wastewater tertiary treatment aimed at removing compounds of emerging concern.
A Trimetallic Pt2NiCo/C Electrocatalyst with Enhanced Activity and Durability for Oxygen Reduction Reaction
Authors: Alfaro-López Hilda M. , Valdés-Madrigal Manuel A. , Rojas-Chávez Hugo , Cruz-Martínez Heriberto , Padilla-Islas Miguel A. , Tellez-Cruz Miriam M. , Solorza-Feria Omar
Published: February 2020

Commercialization of the polymer electrolyte membrane fuel cell (PEMFC) requires that electrocatalysts for oxygen reduction reaction (ORR) satisfy two main considerations: materials must be highly active and show long-term stability in acid medium. Here, we describe the synthesis, physical characterization, and electrochemical evaluation of carbon-dispersed Pt2NiCo nanocatalysts for ORR in acid medium. We synthesized a trimetallic electrocatalyst via chemical route in organic medium and investigated the physical properties of the Pt2NiCo/C nanocatalyst by X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy-scanning electron microscope (EDXS-SEM), and scanning transmission electron microscopy (STEM), whereas the catalytic activities of the Pt2NiCo/C and Pt/C nanocatalysts were determined through cyclic voltammetry (CV), CO-stripping, and rotating disk electrode (RDE) electrochemical techniques. XRD and EDXS-SEM results confirmed the presence of the three metals in the nanoparticles, and scanning transmission electron microscopy (STEM) allowed observation of the Pt2NiCo nanoparticles at ~10 nm. The measured specific activity for the synthesized nanocatalyst is ~6.4-fold higher than that of Pt/C alone, and its mass activity is ~2.2-fold higher than that of Pt/C, which is attributed to the synergistic interaction of the trimetallic electrocatalyst. Furthermore, the specific and mass activities of the synthesized material are maintained after the accelerated stability test, whereas the catalytic properties of Pt/C decreased. These results suggest that the Pt2NiCo/C trimetallic nanocatalyst is a promising candidate cathode electrode for use in PEMFCs.