bluuebunny/crossref_metadata_2025 huggingface dataset:
MLSA phylogeny and antimicrobial susceptibility of clinical Nocardia isolates: a multicenter retrospective study in China
Authors: Wei Ming , Xu Xinmin , Yang Jingxian , Wang Peng , Liu Yongzhe , Wang Shuai , Yang Chunxia , Gu Li
Published: December 2021

Background

With the increase of detection rate and long treatment period, nocardiosis has become a noticeable problem in China. However, there are limited large-scale studies on the epidemiology and antimicrobial susceptibility profiles of clinical Nocardia spp. in China. The present study aimed to explore the species distribution and drug susceptibility pattern of 82 clinical Nocardia isolates from three tertiary hospitals in China by multilocus sequence analysis (MLSA) and broth microdilution (BMD) method.

Results

Pulmonary nocardiosis (90.2%) was the most common clinical presentation of infection. N. cyriacigeorgica (n = 33; 40.2%) and N. farcinica (n = 20; 24.4%) were the most frequently encountered Nocardia species, followed by N. otitidiscaviarum (n = 7; 8.5%), N. abscessus (n = 5; 6.1%), N. asiatica (n = 4; 4.9%), and N. wallacei (n = 4; 4.9%). Trimethoprim/sulfamethoxazole (SXT) remained high activity against all Nocardia isolates (susceptibility rate: 98.8%). Linezolid and amikacin were also highly active; 100 and 95.1% of all isolates demonstrated susceptibility, respectively. Except for N. otitidiscaviarum, all the Nocardia isolates exhibited high susceptibility rates to imipenem. The resistance rates of all isolates to clarithromycin and ciprofloxacin were 92.7 and 73.2%, respectively, but the resistance rate of N. farcinica to ciprofloxacin was only 25%.

Conclusions

The clinically isolated Nocardia spp. had diverse antimicrobial susceptibility patterns, which were similar to the reports by other groups elsewhere, but some differences were also observed, mainly including imipenem and ciprofloxacin. According to this study, SXT still can be the first choice for empirical therapy due to the low resistance rate. Linezolid can be chosen when a patient is allergic to SXT, and amikacin and imipenem can be the choice in a combination regimen.
Observational study on fluid therapy management in surgical adult patients
Authors: Colomina Maria J. , Ripollés-Melchor Javier , Guilabert Patricia , Jover José Luis , Basora Misericordia , Cassinello Concha , Ferrandis Raquel , Llau Juan V. , Peñafiel Judith
Published: December 2021

Background

Perioperative fluid therapy management is changing due to the incorporation of different fluids, surgical techniques, and minimally invasive monitoring systems. The objective of this study was to explore fluid therapy management during the perioperative period in our country.

Methods

We designed the Fluid Day study as a cross-sectional, multicentre, observational study. The study was performed in 131 Spanish hospitals in February 2019. We included adult patients undergoing general anaesthesia for either elective or non-elective surgery. Demographic variables were recorded, as well as the type and total volume of fluid administered during the perioperative period and the monitorization used. To perform the analysis, patients were categorized by risk group.

Results

We recruited 7291 patients, 6314 of which were included in the analysis; 1541 (24.4%) patients underwent high-risk surgery, 1497 (23. 7%) were high risk patients, and 554 (8.7%) were high-risk patients and underwent high-risk surgery; 98% patients received crystalloids (80% balanced solutions); intraoperative colloids were used in 466 patients (7.51%). The hourly intraoperative volume in mL/kg/h and the median [Q1; Q3] administered volume (mL/kg) were, respectively, 6.67 [3.83; 8.17] ml/Kg/h and 13.9 [9.52;5.20] ml/Kg in low-risk patients undergoing low- or intermediate-risk surgery, 6 [4.04; 9.08] ml/Kg/h and 15.7 [10.4;24.5] ml/Kg in high- risk patients undergoing low or intermediate-risk surgery, 6.41 [4.36; 9.33] ml/Kg/h and 20.2 [13.3;32.4] ml/Kg in low-risk patients undergoing high-risk surgery, and 5.46 [3.83; 8.17] ml/Kg/h and 22.7[14.1;40.9] ml/Kg in high-risk patients undergoing high- risk surgery . We used advanced fluid monitoring strategies in 5% of patients in the intraoperative period and in 10% in the postoperative period.

Conclusions

The most widely used fluid was balanced crystalloids. Colloids were used in a small number of patients. Hourly surgery volume tended to be more restrictive in high-risk patients but confirms a high degree of variation in the perioperatively administered volume. Scarce monitorization was observed in fluid therapy management.

Trial registration

Clinical Trials: NCT03630744.
An adaptive gBOIN design with shrinkage boundaries for phase I dose-finding trials
Authors: Mu Rongji , Hu Zongliang , Xu Guoying , Pan Haitao
Published: December 2021

Background

With the emergence of molecularly targeted agents and immunotherapies, the landscape of phase I trials in oncology has been changed. Though these new therapeutic agents are very likely induce multiple low- or moderate-grade toxicities instead of DLT, most of the existing phase I trial designs account for the binary toxicity outcomes. Motivated by a pediatric phase I trial of solid tumor with a continuous outcome, we propose an adaptive generalized Bayesian optimal interval design with shrinkage boundaries, gBOINS, which can account for continuous, toxicity grades endpoints and regard the conventional binary endpoint as a special case.

Result

The proposed gBOINS design enjoys convergence properties, e.g., the induced interval shrinks to the toxicity target and the recommended dose converges to the true maximum tolerated dose with increased sample size.

Conclusion

The proposed gBOINS design is transparent and simple to implement. We show that the gBOINS design has the desirable finite property of coherence and large-sample property of consistency. Numerical studies show that the proposed gBOINS design yields good performance and is comparable with or superior to the competing design.
The association between living environmental factors and adolescents’ body weight: a cross-sectional study
Authors: Huang Siyi , Sha Sha , Du Wei , Zhang Hanwen , Wu Xinyi , Jiang Chongmin , Zhao Yan , Yang Jie
Published: December 2021

Background

The effect of the living environment on public health has received increasingly scholarly attention. This study aims to explore the relationship between adolescents’ body weight and their living environmental factors.

Methods

This cross-sectional study comprised 1362 middle-school students from Nanjing and 826 from Changzhou in China. We further collected information on living environmental factors based on their home address and ran multivariate logistic regressions to explore potential correlations after considering a range of potential confounding factors.

Results

Approximately 25% (n = 303) of students from Nanjing and 26% (n = 205) of students from Changzhou were excessive body weight. In Nanjing, students’ BMI (Body Mass Index) showed a strong negative correlation with the number of sports venues in their neighborhood (Adjusted Odds Ratio (AOR): 0.64, 95%CI: 0.40–0.94) after controlling for other covariates. In Changzhou, we observed a positive correlation between adolescents’ body weight and the number of bus stops in their neighbourhood (AOR:1.63, 95%CI:1.11–2.38).

Conclusions

The living environment factors were independently associated with teenagers’ excessive body weight. We hypothesis that the environmental risk factors might be associated with political management, which will consequently affect personal health outcomes. Further research and proactive measures are required to manage those potential risks and attenuate the problem.
Personalized neoantigen vaccine prevents postoperative recurrence in hepatocellular carcinoma patients with vascular invasion
Authors: Cai Zhixiong , Su Xiaoping , Qiu Liman , Li Zhenli , Li Xiaolou , Dong Xiuqing , Wei Fuqun , Zhou Yang , Luo Liuping , Chen Geng , Chen Hengkai , Wang Yingchao , Zeng Yongyi , Liu Xiaolong
Published: December 2021

Background

Clinically, prophylactic anti-recurrence treatments for hepatocellular carcinoma (HCC) patients after radical surgery are extremely limited. Neoantigen based vaccine can generate robust anti-tumor immune response in several solid tumors but whether it could induce anti-tumor immune response in HCC and serve as a safe and effective prophylactic strategy for preventing postoperative HCC recurrence still remain largely unclear.

Methods

Personalized neoantigen vaccine was designed and immunized for 10 HCC patients with high risk of postoperative recurrence in a prime-boost schedule. The safety and immune response were assessed through adverse events, tissue sequencing, ELISpot, TCR sequencing. The clinical response was evaluated by recurrence-free survival (RFS) and personalized circulating tumor DNA (ctDNA) sequencing.

Results

In the 10 enrolled patients, no obvious adverse events were observed during neoantigen vaccinations. Until the deadline of clinical trial, 8 of 10 patients were confirmed with clinical relapse by imaging, the other 2 patients remained relapse-free. From receiving first neoantigen vaccination, the median RFS of 10 patients were 7.4 months. Among 7 patients received all planned neoantigen vaccinations, 5 of them demonstrated neoantigen-induced T cell responses and have significantly longer RFS after radical surgery than other 5 patients without responsive neoantigens or only with prime vaccination and propensity scores matching control patients (p = 0.035). Moreover, tracking personalized neoantigen mutations in ctDNA could provide real-time evaluation of clinical response in HCC patients during neoantigen vaccination and follow up.

Conclusion

Personalized neoantigen vaccine is proved as a safe, feasible and effective strategy for HCC anti-recurrence, and its progression could be sensitively monitored by corresponding neoantigen mutations in ctDNA, and thus provided solid information for individualized medicine in HCC.

Trial registration

This study was registered at Chinese Clinical Trial Registry; Registration number:ChiCTR1900020990.
A novel biomimetic nanomedicine system with anti-inflammatory and anti-osteoporosis effects improves the therapy efficacy of steroid-resistant nephrotic syndrome
Authors: Li Jian , Zhao Mingyi , Xiang Xinying , He Qingnan , Gui Rong
Published: December 2021

Clinically, steroid-resistant nephrotic syndrome (SRNS) is always prolonged and difficult to treat and easily develops into end-stage renal disease, resulting in a low survival rate. Strategies to reverse steroid resistance and reduce the long-term use of high doses of steroid medicines are urgently needed. In this study, a novel nanoparticle drug system (Pm-GCH) with a core–shell structure was designed. Metal–organic frameworks, synthesized by glycyrrhizic acid (G) and calcium ions (Ca2+) loaded with hydrocortisone (H) were the core of the nanoparticles. Platelet membrane vesicles were the shells. The natural platelet membrane endows Pm-GCH with good biocompatibility and the ability to promote immune escape. In addition, under the chemotaxis of inflammatory factors, platelet membranes assist Pm-GCH in nonspecific targeting of the inflammatory sites of the kidney. Under an inflammatory acid environment, GCH slowly degrades and releases glycyrrhizic acid and hydrocortisone. Glycyrrhizic acid inhibits the inactivation of hydrocortisone, jointly inhibits the activity of phospholipase A2 (PLA2) and the classic activation pathway of complement C2, blocks the production of inflammatory factors, plays an anti-inflammatory role, and enhances the efficacy of hydrocortisone in the treatment of SRNS. Moreover, glycyrrhizic acid alleviates osteoporosis induced by long-term use of glucocorticoids. These results indicate that Pm-GCH is a promising treatment strategy for SRNS.

Graphical Abstract
Lung histopathologic clusters in severe COVID-19: a link between clinical picture and tissue damage
Authors: Wu Maddalena Alessandra , Lopez Gianluca , Nebuloni Manuela , Ottolina Davide , Montomoli Jonathan , Carsana Luca , Fossali Tommaso , Castelli Antonio , Rech Roberto , Cogliati Chiara , Catena Emanuele , Colombo Riccardo
Published: December 2021

Background

Autoptic pulmonary findings have been described in severe COVID-19 patients, but evidence regarding the correlation between clinical picture and lung histopathologic patterns is still weak.

Methods

This was a retrospective cohort observational study conducted at the referral center for infectious diseases in northern Italy. Full lung autoptic findings and clinical data of patients who died from COVID-19 were analyzed. Lung histopathologic patterns were scored according to the extent of tissue damage. To consider coexisting histopathologic patterns, hierarchical clustering of histopathologic findings was applied.

Results

Whole pulmonary examination was available in 75 out of 92 full autopsies. Forty-eight hospitalized patients (64%), 44 from ICU and four from the medical ward, had complete clinical data. The histopathologic patterns had a time-dependent distribution with considerable overlap among patterns. Duration of positive-pressure ventilation (p < 0.0001), mean positive end-expiratory pressure (PEEP) (p = 0.007), worst serum albumin (p = 0.017), interleukin 6 (p = 0.047), and kidney SOFA (p = 0.001) differed among histopathologic clusters. The amount of PEEP for long-lasting ventilatory treatment was associated with the cluster showing the largest areas of early and late proliferative diffuse alveolar damage. No pharmacologic interventions or comorbidities affected the lung histopathology.

Conclusions

Our study draws a comprehensive link between the clinical and pulmonary histopathologic findings in a large cohort of COVID-19 patients. These results highlight that the positive end-expiratory pressures and the duration of the ventilatory treatment correlate with lung histopathologic patterns, providing new clues to the knowledge of the pathophysiology of severe SARS-CoV-2 pneumonia.
Childhood diagnoses in individuals identified as autistics in adulthood
Authors: Rødgaard Eya-Mist , Jensen Kristian , Miskowiak Kamilla Woznica , Mottron Laurent
Published: December 2021

Background

Autism is a developmental condition, where symptoms are expected to occur in childhood, but a significant number of individuals are diagnosed with autism for the first time in adulthood. Here, we examine diagnoses given in childhood among individuals that are diagnosed with autism in adulthood, to investigate whether the late autism diagnosis might be explained by misdiagnosis in childhood or diagnostic overshadowing.

Methods

Through the Danish National Patient Registry, we identified individuals diagnosed with autism in adulthood (N = 2199), as well as a control sample with no records of an autism diagnosis (N = 460,798) and calculated how many had received different psychiatric or neurological diagnoses in childhood.

Results

We found that most childhood diagnoses were overrepresented in those with an adult autism diagnosis, and attention-deficit hyperactivity disorder, affective disorders, anxiety, and stress disorders were the most prevalent childhood conditions in this group. However, 69% of males and 61% of females with adult autism diagnoses were not found to have received any of the investigated diagnoses before 18 years of age, and most childhood diagnoses were given after the age of 12.

Limitations

Milder to moderate cases of psychiatric conditions that have been solely treated by family physicians or school psychologists may not be fully included in our dataset. The study is based on data from the Danish health care system, and further research is needed to assess whether the findings can be generalized to other countries.

Conclusion

A majority of those with an adult autism diagnosis had no records of having received any of the investigated diagnoses in childhood. In these cases, the late autism diagnosis is therefore unlikely to be explained by either misdiagnosis or overshadowing. This result is at odds with the prevailing notion that autistic symptoms tend to diminish with age. Therefore, further research is warranted to examine how and if early signs of autism may have manifested among these individuals, and how similar they are to autistic people diagnosed earlier in their development.
A management model for admission and treatment of pediatric trauma cases
Authors: Tashlizky Madar Raya , Goldberg Avishay , Newman Nitza , Waisman Yehezkel , Greenberg David , Adini Bruria
Published: December 2021

Background

Pediatric trauma, particularly major trauma cases, are often treated in less than optimal facilities by providers who lack training and experience in treating severely injured children. We aimed to develop a management model for admission and treatment of pediatric trauma using the Theory of Constraints (TOC).

Methods

We conducted interviews with 17 highly experienced policy makers, senior nursing managers and medical managers in pediatrics and trauma. The interviews were analyzed by qualitative methods. The TOC was utilized to identify undesirable effects (UDEs) and core challenges, and to design a focused current reality tree (CRT). Subsequently, a management model for optimal admission and treatment of pediatric trauma was constructed.

Results

The CRT was illustrated according to 4 identified UDEs focusing on lack of: (1) clear definitions of case manager in pediatric trauma; (2) uniform criteria regarding the appropriate site for admitting pediatric trauma, (3) standard guidelines and protocols for treatment of trauma cases and for training of trauma medical teams; and (4) standard guidelines for evacuating pediatric trauma patients. The management model for treatment and admission of pediatric trauma is based on 3 major elements: human resources, hospital policy concerning the appropriate emergency department (ED) for pediatric trauma patients and clear definitions regarding children and trauma levels. Each of the elements contains components that should be clearly defined in order for a medical center to be designated for admitting and treating pediatric trauma patients.

Conclusions

Our analysis suggests that the optimal ED for pediatric trauma cases is one with available operating rooms, intensive care beds, an imaging unit, laboratories and equipment suitable for treating children as well as with staff trained to treat children with trauma. To achieve optimal outcomes, medical centers in Israel should be classified according to their trauma treatment capabilities and their ability to treat varied severities of pediatric trauma cases.
In situ observations of ions and magnetic field around Phobos: the mass spectrum analyzer (MSA) for the Martian Moons eXploration (MMX) mission
Authors: Yokota Shoichiro , Terada Naoki , Matsuoka Ayako , Murata Naofumi , Saito Yoshifumi , Delcourt Dominique , Futaana Yoshifumi , Seki Kanako , Schaible Micah J. , Asamura Kazushi , Kasahara Satoshi , Nakagawa Hiromu , Nishino Masaki N. , Nomura Reiko , Keika Kunihiro , Harada Yuki , Imajo Shun
Published: December 2021

The mass spectrum analyzer (MSA) will perform in situ observations of ions and magnetic fields around Phobos as part of the Martian Moons eXploration (MMX) mission to investigate the origin of the Martian moons and physical processes in the Martian environment. MSA consists of an ion energy mass spectrometer and two magnetometers which will measure velocity distribution functions and mass/charge distributions of low-energy ions and magnetic field vectors, respectively. For the MMX scientific objectives, MSA will observe solar wind ions, those scattered at the Phobos surface, water-related ions generated in the predicted Martian gas torus, secondary ions sputtered from Phobos, and escaping ions from the Martian atmosphere, while monitoring the surrounding magnetic field. MSA will be developed from previous instruments for space plasma missions such as Kaguya, Arase, and BepiColombo/Mio to contribute to the MMX scientific objectives.
Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone With Minimal Residual Disease Response-Adapted Therapy in Newly Diagnosed Multiple Myeloma
Authors: Costa Luciano J. , Chhabra Saurabh , Medvedova Eva , Dholaria Bhagirathbhai R. , Schmidt Timothy M. , Godby Kelly N. , Silbermann Rebecca , Dhakal Binod , Bal Susan , Giri Smith , D'Souza Anita , Hall Aric , Hardwick Pamela , Omel James , Cornell Robert F. , Hari Parameswaran , Callander Natalie S.
Published: December 2021

PURPOSE

The MASTER trial combined daratumumab, carfilzomib, lenalidomide, and dexamethasone (Dara-KRd) in newly diagnosed multiple myeloma (NDMM), using minimal residual disease (MRD) by next-generation sequencing (NGS) to inform the use and duration of Dara-KRd post-autologous hematopoietic cell transplantation (AHCT) and treatment cessation in patients with two consecutive MRD-negative assessments.

METHODS

This multicenter, single-arm, phase II trial enrolled patients with NDMM with planed enrichment for high-risk cytogenetic abnormalities (HRCAs). Patients received Dara-KRd induction, AHCT, and Dara-KRd consolidation, according to MRD status. MRD was evaluated by NGS at the end of induction, post-AHCT, and every four cycles (maximum of eight cycles) of consolidation. Primary end point was achievement of MRD negativity (< 10–5). Patients with two consecutive MRD-negative assessments entered treatment-free MRD surveillance.

RESULTS

Among 123 participants, 43% had none, 37% had 1, and 20% had 2+ HRCA. Median age was 60 years (range, 36-79 years), and 96% had MRD trackable by NGS. Median follow-up was 25.1 months. Overall, 80% of patients reached MRD negativity (78%, 82%, and 79% for patients with 0, 1, and 2+ HRCA, respectively), 66% reached MRD < 10–6, and 71% reached two consecutive MRD-negative assessments during therapy, entering treatment-free surveillance. Two-year progression-free survival was 87% (91%, 97%, and 58% for patients with 0, 1, and 2+ HRCA, respectively). Cumulative incidence of MRD resurgence or progression 12 months after cessation of therapy was 4%, 0%, and 27% for patients with 0, 1, or 2+ HRCA, respectively. Most common serious adverse events were pneumonia (6%) and venous thromboembolism (3%).

CONCLUSION

Dara-KRd, AHCT, and MRD response-adapted consolidation leads to high rate of MRD negativity in NDMM. For patients with 0 or 1 HRCA, this strategy creates the opportunity of MRD surveillance as an alternative to indefinite maintenance.
Characterization of Subtypes of BRAF-Mutant Papillary Thyroid Cancer Defined by Their Thyroid Differentiation Score
Authors: Boucai Laura , Seshan Venkatraman , Williams Michelle , Knauf Jeffrey A , Saqcena Mahesh , Ghossein Ronald A , Fagin James A
Published: December 2021

Context

The BRAFV600E mutation has been associated with more advanced clinical stage in papillary thyroid cancer (PTC) and decreased responsiveness to radioiodine (RAI). However, some BRAF mutant PTCs respond to RAI and have an indolent clinical behavior suggesting the presence of different subtypes of BRAF mutant tumors with distinct prognosis.

Objective

To characterize the molecular and clinical features of 2 subtypes of BRAF-mutant PTCs defined by their degree of expression of iodine metabolism genes.

Design

227 BRAF-mutant PTCs from the Cancer Genome Atlas Thyroid Cancer study were divided into 2 subgroups based on their thyroid differentiation score (TDS): BRAF-TDShi and BRAF-TDSlo. Demographic, clinico-pathological, and molecular characteristics of the 2 subgroups were compared.

Results

Compared to BRAF-TDShi tumors (17%), BRAF-TDSlo tumors (83%) were more frequent in blacks and Hispanics (6% vs 0%, P = 0.035 and 12% vs 0%, P = 0.05, respectively), they were larger (2.95 ± 1.7 vs 2.03 ± 1.5, P = 0.002), with more tumor-involved lymph nodes (3.9 ± 5.8 vs 2.0 ± 4.2, P = 0.042), and a higher frequency of distant metastases (3% vs 0%, P = 0.043). Gene set enrichment analysis showed positive enrichment for RAS signatures in the BRAF-TDShi cohort, with corresponding reciprocal changes in the BRAF-TDSlo group. Several microRNAs (miRs) targeting nodes in the transforming growth factor β (TGFβ)-SMAD pathway, miR-204, miR-205, and miR-144, were overexpressed in the BRAF-TDShi group. In the subset with follow-up data, BRAF-TDShi tumors had higher complete responses to therapy (94% vs 57%, P < 0.01) than BRAF-TDSlo tumors.

Conclusion

Enrichment for RAS signatures, key genes involved in cell polarity and specific miRs targeting the TGFβ-SMAD pathway define 2 subtypes of BRAF-mutant PTCs with distinct clinical characteristics and prognosis.
Integrin α6β4 requires plectin and vimentin for adhesion complex distribution and invasive growth
Authors: Qi Lei , Knifley Teresa , Chen Min , O'Connor Kathleen L.
Published: December 2021

Integrin α6β4 binds plectin to associate with vimentin; however, the biological function remains unclear. Here, we utilized various integrin β4 mutants and CRISPR-Cas9 editing to investigate this association. Upon laminin binding, integrin α6β4 distinctly distributed peripherally as well as centrally, proximal to the nucleus. Upon fibronectin addition, integrin α6β4 was centrally recruited to large focal adhesions (FAs) and enhanced Fak (also known as PTK2) phosphorylation. Integrin β4 plectin-binding mutants or genetic deletion of plectin inhibited β4 recruitment to FAs and integrin α6β4-enhanced cell spreading, migration and three-dimensional invasive growth. Loss of the β4 signaling domain (but retaining plectin binding) blocked migration and invasiveness but not cell spreading, recruitment to FAs or colony growth. Immunostaining revealed that integrin α6β4 redistributed vimentin perinuclearly, where it colocalized with plectin and FAs. Depletion of vimentin completely blocked integrin β4-enhanced invasive growth, Fak phosphorylation and proliferation in three dimensions but not two dimensions. In summary, we demonstrate the essential roles of plectin and vimentin in promoting an invasive phenotype downstream of integrin α6β4.

This article has an associated First Person interview with the first author of the paper.
Η πρόκληση της εκπαίδευσης για βιώσιμη/αειφόρο ανάπτυξη στα παιδαγωγικά τμήματα δημοτικής εκπαίδευσης
Authors: Μαρκατάτος Γεώργιος
Published: December 2021

Η διατριβή πραγματεύεται αρχικά το όλο πλαίσιο βάσει του οποίου προτάθηκε η Δεκαετία Εκπαίδευσης για Βιώσιμη Ανάπτυξη (ΔΕΒΑ) των Ηνωμένων Εθνών με διευθύνοντα οργανισμό την UNESCO. Επιχειρεί στη συνέχεια να συμβάλλει στην έρευνα, αναφορικά με την παρακολούθηση και αξιολόγηση της εκπαίδευσης των φοιτητών στα ελληνικά Παιδαγωγικά Τμήματα Δημοτικής Εκπαίδευσης (ΠΤΔΕ), μελετώντας προγράμματα σπουδών και ικανότητες Εκπαίδευσης για Βιώσιμή Ανάπτυξη (ΕΒΑ) που θεωρούν ότι έχουν αναπτύξει οι φοιτητές τους.Ανασκόπηση της σχετικής βιβλιογραφίας προσδιορίζει τις διεθνείς προσπάθειες για αλλαγή του κυριάρχου εκπαιδευτικού παραδείγματος προς την κατεύθυνση της ΕΒΑ, τη θεματολόγια αυτής καθώς και τις διδακτικές και παιδαγωγικές μεθόδους στις οποίες βασίζεται. Επισημαίνεται η σημασία που έχει η βασική εκπαίδευση των υποψηφίων εκπαιδευτικών προκειμένου αυτοί να είναι σε θέση να συμβάλλουν στον αναγκαίο αναπροσανατολισμού του εκπαιδευτικού παραδείγματος. Στο πλαίσιο της ανάγκης για αξιολόγηση της επίδρασης που έχει η ΔΕΒΑ στα ΠΤΔΕ Ελλάδος, μελετήθηκαν τα προσφερόμενα μαθήματά τους για τη χρονική περίοδο 2007 με 2011, με θεματική ανάλυση περιεχομένου των οδηγών σπουδών τους. Μέσα από τη μελέτη των μαθημάτων, εμφανίζεται σε πολλά από αυτά να πραγματεύονται κοινωνικά, περιβαλλοντικά και πολιτιστικά ζητήματα καθώς επίσης και να προτείνονται διδακτικές μέθοδοι σύμφωνες με όσα αναφέρονται στη βιβλιογραφία στο πλαίσιο της ΕΒΑ. Αυτό ωστόσο που έχει ενδιαφέρον είναι ότι στη συντριπτική πλειονότητα των μαθημάτων, η ορολογία που χρησιμοποιείται στις περιγραφές αυτών δεν εμπεριέχει τις έννοιες βιωσιμότητα ή αειφορία. Μάλιστα οι έννοιες αυτές εμφανίζονται συνήθως σε μαθήματα που σχετίζονται με την περιβαλλοντική εκπαίδευση. Αξιοσημείωτο τέλος είναι ότι ελάχιστα μαθήματα σε όλα τα ΠΤΔΕ πραγματεύονται «οικονομικά» και «αναπτυξιακά» ζητήματα.Αναφορικά με το πώς αυτοπροσδιορίζουν οι τεταρτοετείς φοιτητές των ΠΤΔΕ Ελλάδος τις ικανότητές τους στην ΕΒΑ, έγιναν περιγραφικές και επαγωγικές στατιστικές αναλύσεις των ποσοτικών δεδομένων που προέκυψαν από δομημένο ανώνυμο ερωτηματολόγιο το οποίο μοιράστηκε σε δείγμα 864 τεταρτοετών φοιτητών το 2011. Με βάση τα αποτελέσματα εμφανίζονται οι φοιτητές των ΠΤΔΕ να αυτοπροσδιορίζουν σε όλους τους τομείς υψηλές προσωπικές ικανότητες ΕΒΑ. Στο πλαίσιο αυτό φαίνεται ωστόσο να είναι χαμηλή η επίδραση του τμήματος στο οποίο φοιτούν.Το συνολικό συμπέρασμα είναι ότι οι προσπάθειες αναμόρφωσης των οδηγών σπουδών των ΠΤΔΕ Ελλάδος, προς την κατεύθυνση της ΕΒΑ, πρέπει να συνεχιστούν καθώς και ότι υπάρχει ανάγκη για περαιτέρω έρευνα αναφορικά με ικανότητες ΕΒΑ υποψήφιων εκπαιδευτικών.
Η πολιτική οικονομία της ευρωπαϊκής τραπεζικής ένωσης
Authors: Καζαντζής Κωνσταντίνος
Published: December 2021

Η απόφαση εγκαθίδρυσης τραπεζικής ένωσης αποτέλεσε την κύρια απάντηση της Ευρωζώνης στην ευρωπαϊκή κρίση δημοσίου χρέους, αποσκοπώντας στο σπάσιμο του φαύλου κύκλου μεταξύ των προβληματικών τραπεζών και των αδύναμων δημοσιονομικά χωρών. Όμως, ο θεσμικός της σχεδιασμός ήταν αρκετά διαφοροποιημένος συγκριτικά με την πρόταση της «Έκθεσης των Τεσσάρων Προέδρων». Μέλημα της διατριβής είναι να ρίξει φως στις θεσμικές επιλογές που έγιναν στα πλαίσια της τραπεζικής ένωσης. Έτσι, αρχικά επιχειρεί να αναδείξει τα εθνικά συμφέροντα που σχημάτισαν τις εθνικές προτιμήσεις των κύριων κρατών-μελών (Γερμανία, Γαλλία, Ισπανία και Ιταλία) γύρω από τον βαθμό υπερεθνικής διακυβέρνησης και τον βαθμό επιμερισμού κινδύνου στους τρεις πυλώνες της τραπεζικής ένωσης (Ενιαίος Εποπτικός Μηχανισμός, Ενιαίος Μηχανισμός Εξυγίανσης, Ευρωπαϊκό Σύστημα Εγγύησης Καταθέσεων), ενώ στη συνέχεια εξετάζει την ύπαρξη ασύμμετρης αλληλεξάρτησης στη διαπραγμάτευση της τραπεζικής ένωσης ώστε να εξηγήσει τις θεσμικές επιλογές που έγιναν σε αυτή. Ο φιλελεύθερος διακυβερνητισμός είναι το θεωρητικό πλαίσιο που θα επιλεγεί, εντός του οποίου αναλύονται τα εμπειρικά δεδομένα που αντλούνται με σκοπό την εξαγωγή ευρύτερων συμπερασμάτων.
Ανίχνευση υποκειμένου οργανικού υποστρώματος σε ασθενείς με κοιλιακές αρρυθμίες
Authors: Νικολαΐδου Χρυσοβαλάντου
Published: December 2021

Οι συνήθεις απεικονιστικές μεθόδοι αδυνατούν να αναγνώρισουν δομικές ανωμαλίες σε ένα σημαντικό ποσοστό ασθενών με ιδιοπαθείς κοιλιακές αρρυθμίες. Η μυοκαρδιακή παραμόρφωση έχει αναδειχθεί ως ανώτερος δείκτης της συστολικής απόδοσης σε σχέση με το κλάσμα εξώθησης. Σκοπός της παρούσας διατριβής ήταν η εκτίμηση της διαγνωστικής αξίας της Μαγνητικής Τομογραφίας Καρδιάς (ΜΤΚ), συμπεριλαμβανομένης της μυοκαρδιακής παραμόρφωσης με την τεχνική feature-tracking σε ασθενείς με συχνές κοιλιακές αρρυθμίες και φυσιολογικές δομικά καρδιές. Στη μελέτη συμπεριλήφθηκαν 72 ασθενείς (μέση ηλικία 46 ± 16 έτη, 53% γυναίκες) με συχνά πρώιμα κοιλιακά συμπλέγματα (ΠΚΣ ≥ 500/24ωρο) και/ή μη εμμένουσα κοιλιακή ταχυκαρδία, φυσιολογικό υπερηχοκαρδιογράφημα και αρνητική μελέτη για στεφανιαία νόσο, καθώς και 72 υγιείς εθελοντές. Η ΜΤΚ παρείχε επιπλέον διαγνωστική αξία στο 54,2% των ασθενών. Η συχνότερη διάγνωση ήταν η προηγούμενη μυοκαρδίτιδα (23,6%), ακολουθούμενη από μυοκαρδιοπάθεια προκαλούμενη από ΠΚΣ (20,8%), μη ισχαιμική μυοκαρδιοπάθεια (8,3%), και ισχαιμική καρδιακή νόσος (1,4%). Το αρσενικό φύλο, η μεγαλύτερη ηλικία και η προέλευση της κοιλιακής αρρυθμίας εκτός των χώρων εξόδου των κοιλιών ή αρρυθμίες με πολλαπλές μορφολογίες, αποτελούσαν ανεξάρτητους προγνωστικούς παράγοντες παθολογικών ευρημάτων στη ΜΤΚ. Σε σχέση με τους υγιείς εθελοντές, οι ασθενείς με κοιλιακές αρρυθμίες είχαν επηρεασμένη μέγιστη συνολική ακτινική παραμόρφωση (GRS) (28,88% [IQR: 25,87% έως 33,97%] έναντι 36,65% [IQR: 33,19% έως 40.,2%], p < 0,001) και μέγιστη συνολική κυκλοτερή παραμόρφωση (GCS) της αριστερής κοιλίας (-17,73% [IQR: -19,8% έως -16,33%] έναντι -20,66% [IQR: -21,72% έως -19,6%], p < 0,001). Οι ασθενείς με χαμηλότερο GRS (<29,91%) είχαν 5 φορές μεγαλύτερη πιθανότητα να πάσχουν από κοιλιακές αρρυθμίες. Συμπεραίνουμε ότι η ΜΤΚ αποκαλύπτει υποκείμενο οργανικό υπόστρωμα και επηρεασμένη μυοκαρδιακή παραμόρφωση σε έναν σημαντικό αριθμό ασθενών με ιδιοπαθείς κοιλιακές αρρυθμίες. Το αρσενικό φύλο, η μεγαλύτερη ηλικία και η προέλευση της κοιλιακής αρρυθμίας εκτός των χώρων εξόδου των κοιλιών, μπορεί να αποτελέσουν κλινικά κριτήρια για παραπομπή για ΜΤΚ.
Zmiany nazw miast w Generalnym Gubernatorstwie (1939–1945). Wstęp do germanizacji czy wyraz pragmatyzmu okupanta?
Authors: Przegiętka Marcin
Published: December 2021

W artykule przedstawiono zmagania niemieckiej administracji Generalnego Gubernatorstwa z polskimi nazwami miejscowości. Polityka w zakresie ich zmian – dostosowania do umiejętności językowych niemieckich urzędników lub germanizowania, nie była konsekwentna. Kompleksową próbę zmiany nazw – przede wszystkim miast – w GG podjęto dopiero w 1941 r., a w 1943 r. rozszerzono na dystrykt galicyjski. Ich zakres był jednak niewielki, co należy tłumaczyć oporami samej administracji GG oraz innych instytucji – m.in. Wehrmachtu. Chociaż ustalanie urzędowych nazw miejscowości generalny gubernator zastrzegł do swojej wyłącznej kompetencji, inicjatywę w tym zakresie przejmowali nieraz naczelnicy powiatów, samowolnie germanizując nazwy miast lub usuwając z nich polskie znaki diakrytyczne
Andrzej Chwalba, Przegrane zwycięstwo. Wojna polsko-bolszewicka 1918-1920, Wołowiec 2020, ss. 387.
Authors: Goclon Jacek Arkadiusz
Published: December 2021

Recenzja książki Andrzeja Chwalby   Przegrane zwycięstwo. Wojna polsko-bolszewicka 1918-1920, Wołowiec 2020, ss. 387.
Ogólnopolska konferencja naukowa „Badania historii kobiet polskich na tle porównawczym. Kierunki, problematyka, perspektywy”. Białystok 11–13 czerwca 2021
Authors: Wodniak Katarzyna
Published: December 2021

Sprawozdanie  z konferencji naukowej „Badania historii kobiet polskich na tle porównawczym. Kierunki, problematyka, perspektywy”. Białystok 11–13 czerwca 2021
О некоторых тенденциях развития и изучения криминальной литературы в современной России (краткий обзор)
Authors: Fedunina Olga
Published: December 2021

В статье дается обзор основных тенденций развития и изучения российской криминальной литературы новейшего периода. Обосновывается необходимость жанрового подхода к исследованию ее поэтики. Намечаются связи с жанровыми традициями мировой криминальной литературы и ее соцреалистического варианта. Линию полицейского романа, ориентированную больше на этическую проблематику, продолжает А. Маринина. Однако в целом этот жанр оказывается заслонен крутым детективом. Еще один ведущий криминальный жанр, „расследование жертвы”, фактически замещается другой моделью, где сюжет определяется противостоянием человека и государственной (или мафиозной) системы. Выделяется также ведущая роль „авантюрного расследования” (термин Н. Кириленко), которое реализуется в произведениях разного художественного уровня (Б. Акунин, Д. Донцова и др.). Очевидно, его рационально-игровая природа в большей степени соответствует эпохе постмодернизма.
Jak kryminał przekracza granice popkultury? O schemacie kryminalnym w twórczości Patricka Modiano
Authors: Tuszyńska Justyna
Published: December 2021

Schematyczność, rozumiana jako powtorzenie, jest jednym z podstawowych kryteriow podziału literatury na popularną i wysokoartystyczną. Fascynująca wydaje się zatem tworczość pisarza – noblisty, ktora opiera się na obsesyjnie powtarzanych motywach, figurach i wątkach. W tworczości Patricka Modiano nieustannie powracają bowiem schematy powieści kryminalnej oraz klisze przejęte z tradycji literackiej, przede wszystkim francuskiej. Artykuł jest probą odpowiedzi na pytanie: dlaczego i w jaki sposob Patrick Modiano wykorzystuje schemat kryminalny? Wybrane utwory autora (Ulica ciemnych sklepikow, Zagubiona dzielnica, Dora Bruder, Żebyś nie zgubił się w dzielnicy) zostały poddane analizie w kontekście strategii charakterystycznych dla konwencji kryminalnej. Pozwoliła ona wskazać trzy najważniejsze funkcje kryminału w tworczości Modiano; użycie schematu kryminalnego jako: odzwierciedlenia mechanizmow pamięci, skonwencjonalizowanej formy literackiej komunikacji oraz przedstawienia przymusu powtarzania. Przykład tworczości francuskiego noblisty pokazuje, jak kryminał przekracza granice literatury popularnej, co prowadzi nas do pytania, czy tradycyjne kategorie literackie są dziś jeszcze użytecznym narzędziem badawczym.
SUPPLIER FAIRNESS PERCEPTION AS A MEDIATING FACTOR IN THE SUPPLIER ROLE PERFORMANCE—THE RELATIONSHIP QUALITY OF SUPPLY CHAIN
Authors: SUN YU-LING , LI YI-DI , WANG HONG
Published: December 2021

Suppliers play an important role in the agricultural product supply chain and their behavior could influence significantly relationship quality of supply chain. However, the role performance of agricultural product suppliers is usually ignored, which affects the decision-making establishment of relationship quality among supply chain members. In addition, fairness perception by agricultural product suppliers will also affect the quality of supply chain relationships. This work takes the agricultural product supply chain as the research object and investigates how the supplier role performance affects the relationship quality of supply chain. An empirical study is conducted through questionnaire-related data based on the model. The research results show that supplier role performance has a significant positive effect on the relationship quality, and the distributive fairness of supplier has a significant intermediary effect on both supplier role performance and relationship quality of the supply chain. In addition, price satisfaction has a positive impact on commitments when considering the fairness perception of suppliers.
A PRACTICAL STUDY ON LOGISTICS RESPONSE TO PUBLIC HEALTH EMERGENCIES IN COLLEGES AND UNIVERSITIES FROM THE PERSPECTIVE OF FINE MANAGEMENT—TAKING LOGISTICS SUPPORT OFFICE OF CHINA UNIVERSITY OF GEOSCIENCES (WUHAN) AS AN EXAMPLE
Authors: XU LI , LI LUN
Published: December 2021

The healthy development of higher education cannot be separated from the strong support and guarantee of university logistics. In the face of public health emergencies, if we want to further strengthen the function of logistics support and support in colleges and universities, and enhance the awareness and ability of coping, we should first start with delicacy management. After the baptism of Novel Coronavirus (2019-nCoV) epidemic, it is necessary for the logistics of universities to sum up their experience carefully, make good plans ahead of time, and make full response and preparation for all kinds of public health emergencies that may occur in the future. And this provides Chinese wisdom and Chinese plan for colleges and universities around the world to deal with public health emergencies.
EXPERIENCES AND IMPLICATIONS OF COVID-19 PREVENTION AND CONTROL IN CHINA
Authors: GUI YU-QING , LI YONG-KANG , WANG HONG-LI , WU DAN
Published: December 2021

Chinese government has implemented a series of prevention and control strategies and measures in the face of COVID-19, the spread of the local epidemic has been basically stopped, prevention and control of the epidemic has entered a normal stage. This paper analyzes and summarizes the successful experience of Chinese government in combating the COVID-19 epidemic since January 2020, and puts forward relevant suggestions, adapt to local conditions and apply them to the current fight against the epidemic. It is hoped to provide useful reference for fighting the epidemic under the new situation and contribute wisdom to jointly winning the fight against the virus.
ANALYSIS ON CROSS-BORDER E-COMMERCE DEVELOPMENT IN FUJIAN
Authors: CHEN XIAO-QING , YAO HUI-LIN
Published: December 2021

Firstly, this paper analyses the development status of Cross-border E-commerce in Fujian. Secondly, it explores the advantages, disadvantages, opportunities and challenges of the development of Cross-border E-commerce in Fujian, so as to understand the problems existing in the development of Cross-border E-commerce in Fujian. Finally, the paper puts forward corresponding counter measures.
RESEARCH ON THE IMPACT OF DIGITAL FINANCE ON CORPORATE FINANCIAL FLEXIBILITY UNDER THE BACKGROUND OF THE NEW DEVELOPMENT PATTERN OF "DOUBLE CYCLES"
Authors: ZHU FENG-XIN , DING YU-FANG , ZHAO YA-MING
Published: December 2021

This paper selects 2013-2018 data of A-share manufacturing companies in Shanghai and Shenzhen stock markets as samples, and uses the method of double differentiation to study the impact of the policy of promoting the development of digital finance on the level of corporate financial flexibility under the background of the new development pattern of "double cycles". The research result shows that after the promotion of digital finance, the level of corporate financial flexibility has been significantly reduced. Finally, based on the above conclusions, this article puts forward relevant suggestions for enterprises and governments to improve resource utilization efficiency and rationally guide the development of digital finance.
ENVIRONMENTAL PROTECTION INVESTMENT AND BUSINESS PERFORMANCE OF ENTERPRISES UNDER THE INFLUENCE OF ENVIRONMENTAL REGULATION
Authors: ZHOU HONG , QIAO JUN-GUO
Published: December 2021

The 11th Five-Year Plan of China has established obligatory targets for main pollutant emissions while the completion of the targets has been associated with the achievements of local officials. With the full implementation of this plan, many enterprises began to take forward-looking environmental protection strategies to cope with the increasingly stringent environmental regulations. Most of the existing literature have systematically studied the impact of environmental regulation from the perspective of industry or region, but they have not considered the dynamic response of enterprises to environmental regulation. The research on the economic consequences of enterprises adopting forward-looking environmental protection strategies for environmental protection investment at the micro level is relatively insufficient. This paper uses the data of China's listed manufacturing companies from 2011 to 2017 to study the effect of environmental protection investment on their business performance of enterprises. The results show that environmental protection investment has a positive cumulative effect on company’s business performance, especially in non-state-owned enterprises. Based on this conclusion, this paper puts forward relevant policy suggestions to promote enterprises to implement forward-looking environmental protection strategy and gain competitive advantage.
RESEARCH ON THE RELATIONSHIP BETWEEN INVESTOR SENTIMENT AND STOCK PRICE
Authors: DU YI-MING , DING RUI , ZHANG YI-LIN , ZHANG TING , ZHOU TAO
Published: December 2021

As one of the main contents of behavioral finance, investor sentiment has become a research hotspot in recent years. This paper takes the CSI300 index of China as the observation object, selects five emotional monthly time series data including lag one period from 2016 to 2020. The method of principal component analysis will be used to reduce the dimension of 10 groups of data. After eliminating the macroeconomic factors, the dimension reduction results are analyzed by the second principal component analysis to obtain the comprehensive index of emotion. Furthermore, a Vector Auto Regressive model (VAR) is established to investigate the relationship between ISIO and CSI300 of the stock market. The results show that investor sentiment and stock price interact with each other, but only in the short term. With more and more sufficient market information known, the effect is becoming insignificant.
COLLABORATIVE SUPERVISION OF SERVICE-ORIENTED DIGITAL PLATFORMS
Authors: CUI QIAN , ZHENG LI-XIU
Published: December 2021

Under the background of the current digital age, the development of digital platforms is showing a rapid trend, which also leads to corresponding governance and supervision issues. This article mainly discusses the situation that the current service-based digital platform's role changes, the inapplicability of traditional regulatory rules, and the platform's monopolistic characteristics affect the healthy development of the market economy. The service-based digital platform should be coordinated with multiple entities. At the same time, it is necessary to adhere to the principles of inclusiveness, prudence and applicability in the supervision process, and adopt intelligent supervision methods to achieve the effect of effective governance and supervision of the service-oriented digital platform.
RESEARCH ON THE INTERNET PLUS PROMOTING TAX LAW REFORM AND INNOVATION IN THE ERA OF BIG DATA
Authors: TAO QUAN
Published: December 2021

In the era of big data, it is particularly necessary to use Internet plus technology to promote tax law teaching reform and innovation. This paper analyzes the current situation, points out the existing problems, and puts forward specific measures for Internet plus promoting tax reform and innovation in the era of big data, so as to facilitate the reform and development of tax law teaching in Chinese universities. In the era of big data, with the rapid development of computer technology and the continuous improvement of Internet plus, people's lives have entered the information society. People are increasingly demanding information, big data has become a hot term, and infiltrate into various industries. Nowadays, science and technology are developed, big data information is unblocked, people communicate more closely, life is more convenient, big data is the product of high-tech era.“ Internet plus” is the new form of Internet development under the innovation, which promotes social and economic entities and becomes a platform for reform, innovation and development. Internet plus relying on Internet technology to integrate Internet and traditional industries, optimize production factors and restructure business models to achieve economic transformation and upgrading, give full play to the advantages of the Internet, upgrade industrial productivity and increase social wealth by upgrading industries. Through the characteristics of openness, equality and interaction, the Internet uses big data analysis to transform the traditional industrial model and enhance the power of economic development, so as to promote the healthy and rapid development of national economy [1]. Based on the background of Internet plus in the era of big data, this article discusses the development and innovation of tax law teaching reform in our country. It expects that the traditional tax law teaching mode can help students integrate new teaching and big data technology with the help of big data technology and Internet plus platform, and better train new talents suitable for the big data era. It is a contribution to the construction and economic development of "double first-class" in universities in China.
One-Step Estimation with Scaled Proximal Methods
Authors: Bassett Robert , Deride Julio
Published: December 2021

We study statistical estimators computed using iterative optimization methods that are not run until completion. Classical results on maximum likelihood estimators (MLEs) assert that a one-step estimator (OSE), in which a single Newton-Raphson iteration is performed from a starting point with certain properties, is asymptotically equivalent to the MLE. We further develop these early-stopping results by deriving properties of one-step estimators defined by a single iteration of scaled proximal methods. Our main results show the asymptotic equivalence of the likelihood-based estimator and various one-step estimators defined by scaled proximal methods. By interpreting OSEs as the last of a sequence of iterates, our results provide insight on scaling numerical tolerance with sample size. Our setting contains scaled proximal gradient descent applied to certain composite models as a special case, making our results applicable to many problems of practical interest. Additionally, our results provide support for the utility of the scaled Moreau envelope as a statistical smoother by interpreting scaled proximal descent as a quasi-Newton method applied to the scaled Moreau envelope.