bluuebunny/crossref_metadata_2025 huggingface dataset:
Dental autotransplant: case report
Authors: Nathália Martins Pacini  , Dirceu Tavares Formiga Nery  , Daniel Rey de Carvalho  , Normeu Lima Junior  , Alexandre Franco Miranda  , Sérgio Bruzadelli Macedo
Published: September 2022

The autogenous transplantation or dental autotransplantation is defined as the replacement of an absent or impaired tooth by another transplanted one, usually the third molar. The tooth is transplanted to a prepared or existing tooth socket occupied by the lost tooth, in a same person. This technique is considered a viable method due to its high success rate when properly indicated combined with a relatively low cost. Objective and case report: To report a clinical case study conducted in the Integrated Clinics of the Catholic University of Brasilia in a young melanoderm male patient, 13 years-old, who underwent late tooth transplantation technique, i.e., in two steps: the right upper third molar was transplanted to the socket of the right lower first molar. The case described showed incomplete root formation and radiographic following-up for eight consecutive months. Conclusion: This type of oral rehabilitation contributed to bone formation stimulation at the transplanted site, the maintenance of the masticatory function and the financial costs reduction for the patient, representing a further possible therapy in the dentist’s armamentarium.
Antimicrobial activity of sodium hypochlorite, chlorhexidine and MTAD® against Enterococcus faecalis biofilm on human dentin matrix in vitro
Authors: Cristiana Francescutti Murad  , Luciana Moura Sassone  , Monica Cristina Souza  , Rivail Antonio Sergio Fidel  , Sandra Rivera Fidel  , Rafael Hirata Junior
Published: September 2022

This study evaluated the antimicrobial efficacy of 2.5% and 5.25% NaOCl, 2% gel and liquid CHX and MTAD against Enterococcus faecalis biofilms on human dentin. Material and methods: E. faecalis biofilms grown on dentin matrix of 216 root sections were submerged in test irrigants for 1, 5, 15 and 30 minutes. The antimicrobial activity of the test irrigants were assessed through CFU counts. Biofilm formation over the dentin surface was ensured by SEM analysis. Results: Results showed no statistic difference among CHX gel, 2.5% and 5.25% NaOCl. However, the CHX liquid and MTAD were less effective than 2.5% and 5.25% NaOCl. Only CHX liquid and MTAD had differences in its efficacy depending on the time. Conclusion: The most effective irrigants in eliminating E. faecalis biofilms were 2.5% and 5.25% NaOCl and 2% CHX gel, at all the tested time intervals, in comparison to CHX liquid and MTAD.
Effectiveness of an electronic apex locator used after preflaring of cervical and middle third
Authors: João Marcelo da Silva Teixeira  , Myrna Bastos Barcellos  , Marco André de Berrêdo Pinho  , Carlos Augusto de Melo Barbosa  , Rivail Antônio Sérgio Fidel  , Sandra Rivera Fidel
Published: September 2022

The electronic method has been studied and improved aiming to add precision, speed and reliability of the measurement technique to determine the exact location of the working length. Currently, the root canal preparation recommends prior to determine the tooth length and consequent perform instrumentation of the apical portion, a previous preflaring of the cervical and middle thirds in various techniques. This procedure may provide a reduction in system impedance, leading to read errors by the apex locators. Objective: Investigate the influence of preflaring of the cervical and middle thirds on the accuracy of measuring the working length by apex locators. Material and methods: Twenty-five mesial roots of molars were used and had their crowns cut at the cemento-enamel junction. The actual measure of each root canal was performed and then the samples were embedded into a mixture of alginate, used as a conducting medium, where electronic measurements were taken with apex locator before and after preflaring of the canals with Gates-Glidden drills in descending order (#4, #3, #2). Measurements obtained by electronic method were then compared with the actual measurement of the root canal. The results were tabulated and submitted to the Student t test Results: The results show that there was no statistical significance (p<0.05) between the readings before and after preflaring. Readings closer to the foraminal ending occurred in the group after preflaring with Gates Glidden. Conclusion: It was concluded that preflaring with Gates Glidden drills were not able to influence significantly the accuracy of apex locator in determining the exact working length.
Erupted odontomas: a report of two unusual cases
Authors: Santosh Patil  , Farzan Rahman  , Shoaib R. Tipu  , Sumita Kaswan
Published: September 2022

Odontomas are the most common odontogenic tumors of the jaws which are benign, slow growing and nonaggressive. They are usually asymptomatic and are diagnosed on routine radiological examination. The eruptions of odontomas are uncommon and very few cases are reported in the literature. Objective: To report two rare cases of erupted compound odontomas. Case report: Two cases of erupted compound odontomas are reported in middle aged patients. Erupted miniature teeth-like structure were seen on clinical examination. The condition was diagnosed on the basis of conventional intraoral radiographs and histopathological examination. Both cases were treated by surgical excision under local anaesthesia without any complications. Conclusion: Odontomas are benign tumors with uncertain etiology. Odontomas erupting in the oral cavity is an infrequent situation. Surgical excision is the treatment of choice in all such cases followed by histopathological examination to confirm the clinical diagnosis.
Surgical approach and the use of cryotherapy in a keratocystic odontogenic tumor after 12 months of decompression
Authors: Claudio Maranhão Pereira  , Danilo Santos Carneiro  , Renan Correia Arcanjo  , Mauro Silva Filho  , Flávio Augusto Cardoso da Silva  , Alberto Ferreira da Silva Júnior
Published: September 2022

The Keratocystic Odontogenic Tumor (KOT) is a pathology classified as an odontogenic cyst and began to be considered an odontogenic tumor in 2005, because of the presence of intrinsic characteristics compatible with neoplasm, such as its high rate of recurrence and differentiated mechanism of growth. Although its etiology is still unknown, its origin is believed to be related to the remnants of the dental lamina. Clinically it presents aggressive behavior and high rates of recurrence. Various types of treatment have been related, ranging from more conservative methods to radical surgery. With the goal of diminishing the potential for recurrence of these lesions, some authors have recommended the use of adjunct therapies such as peripheral osteotomy with burs, treatment of the surgical site with Carnoy’s solution, electrocauterization, cryotherapy and resection. Objective: The aim of the present study is to report the case of a patient with a KOT of large proportions in the mandible.Case report: Treatment was taken to perform decompression of the lesion for 12 months, and after this treatment comprised curettage and cryotherapy. Conclusion: This procedure is considered useful and conservative, as it avoids traumatisms to the noble structures close to the lesion.
Current Naturopathy to Combat Alzheimer’s Disease
Authors: Chakrovorty Arnob , Bhattacharjee Banani , Saxena Aaruni , Samadder Asmita , Nandi Sisir
Published: September 2022

Neurodegeneration is the progressive loss of structure or function of neurons, which may ultimately involve cell death. The most common neurodegenerative disorder in the brain happens with Alzheimer's disease (AD), the most common cause of dementia. It ultimately leads to neuronal death, thereby impairing the normal functionality of the central or peripheral nervous system. The onset and prevalence of AD involve heterogeneous etiology, either in terms of genetic predisposition, neurometabolomic malfunctioning, or lifestyle. The worldwide relevancies are estimated to be over 45 million people. The rapid increase in AD has led to a concomitant increase in the research work directed towards discovering a lucrative cure for AD. The neuropathology of AD comprises the deficiency in the availability of neurotransmitters and important neurotrophic factors in the brain, extracellular betaamyloid plaque depositions, and intracellular neurofibrillary tangles of hyperphosphorylated tau protein. Current pharmaceutical interventions utilizing synthetic drugs have manifested resistance and toxicity problems. This has led to the quest for new pharmacotherapeutic candidates naturally prevalent in phytochemicals. This review aims to provide an elaborative description of promising Phyto component entities having activities against various potential AD targets. Therefore, naturopathy may combine with synthetic chemotherapeutics to longer the survival of the patients.
Relationship Between Handgrip Strength and Age in the Body Composition Variables Among People Living with HIV
Authors: Gouvêa-e-Silva Luiz Fernando , Silva Camila Ferreira , Araujo Izabella Bernardes , Lima Vitória Souza , Fernandes Eduardo Vignoto , Xavier Marília Brasil
Published: September 2022

Background:

The study of aging and handgrip strength (HGS) is important to gain knowledge regarding health care and quality of life in people living with HIV (PLHIV).

Objective:

The aim of the study is to analyze the relationship between HGS and age in the body composition variables of PLHIV.

Methods:

The sample consisted of 77 PLHIV, divided into three groups: G40 – PLHIV aged 40-49 years (n=39); G50 – PLHIV aged 50-59 years (n=26); and G60 – PLHIV aged 60-69 years (n=12). Data collection included anamnesis (sociodemographic, clinical, and laboratory information), physical assessment (body composition and HGS), and physical activity level. Data were analyzed by descriptive and inferential statistics.

Results:

It was noted that men, compared to women, are 5.85 times more likely to present adequate HGS (pp<0.00.001). In addition, adequate HGS was associated with adequate values of body mass index (p<0.001), waist circumference (p<0.001), and fat percentage (p<0.001). The G40 and G50 groups, in relation to the G60, were associated with adequate abdominal circumference (p=0.04).

Conclusion:

Monitoring the evolution of HGS in PLHIV, over time, makes it possible to infer about body fat and muscle mass, in order to propose prevention actions and guidelines to prevent early muscle loss, the development of overweight/obesity, and abdominal obesity.
Analytical Aspects for Evaluation of Pharmaceutical Products: A Mini- Review
Authors: Kogawa Ana Carolina , Lustosa Isadora Alves , de Souza Gil Eric
Published: September 2022

Background:

The pharmaceutical industry is in constant development, aiming to increase its portfolio, optimizing time, product quality and efficacy along with patient safety. The main goal of developing and validating an analytical method is to achieve a balance between costs and risks within the wide array of technical possibilities in order to assure that the method is capable of meeting its expectations, ensuring effective quality control.

Objective:

The objective of this mini-review is to discuss the analytical aspects of development and validation for analysis of pharmaceutical products, focusing on the complete evaluation package in a systematic way to demonstrate the optimal performance of the method.

Methods/Results:

Validation results are obtained following strict protocols, typically starting with the assessment of selectivity/specificity parameters, followed by parameters such as linearity and precision. Moreover, accuracy, detection limit, quantification limit and method robustness are also evaluated.

Conclusion:

This paper may serve as a guide for the pharmaceutical-chemical laboratory, conceptualizing quality and current analytical needs, according to Green Analytical Chemistry, for the development and validation of reliable methods, ensuring clarity to the analyst and assisting in decision making.
Unravelling the Influence of Nutrition and Mental Stress on Immune
Response
Authors: Mishra Rashmi , Pandey Pratibha , Khan Fahad
Published: September 2022

The review reveals the role of mental as well as biological phenomena working behind
immunity. In recent times, irresistible illnesses and inflammation have been thought to be hereditary
or the result of the natural working mechanism of the human body in response to the pathogenic
variables working inside the human system. In the past few years, the importance of psychological
adjustments, mental well-being and eating habits has been studied and shown to have a marked
effect on immunity. Psychoneuroimmunology considers that mental disorders are strongly interrelated
with the resistant reaction. Besides, the immunological components control the well-being of
the individual. Psychosocial mediations help reduce disease severity and enhance the functioning
of the immune system. Nutrition plays a vital role in immunity and thus has an influence on our
mental health.
Sericic Acid Ameliorates DSS-induced Ulcerative Colitis in Mice by Modulating
the NF-κB and Nrf2 Pathways
Authors: Liu Dailin , Lifei-Luo  , Zhang Jingze , Li Xinyu , Zhu Yanru , Wang Yansheng
Published: September 2022

Background:

Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease. In previous studies, we found extracts from the roots of Rosa odorata Sweet var. gigantea (Coll.et Hemsl.) Rehd. et Wils have a therapeutic effect on UC. Furthermore, sericic acid (SA) is a pentacyclic triterpenoid isolated from this plant that is being used for the first time. The purpose of this study was to investigate whether SA has anti-inflammatory and therapeutic effects on UC and its underlying mechanisms.

Methods:

In this study, we used a dextran sulfate-induced UC mouse model and lipopolysaccharide (LPS)-induced inflammatory cell model along with an enzyme-linked immunosorbent assay(ELISA) to quantify the abundance of inflammatory factors and oxidative stress factors in tissues and cells. HE staining was used to analyze the therapeutic effect of the drugs on the UC mouse model. The expression levels of oxidative stress-related proteins were detected using immunoblotting and immunohistochemistry. The anti-inflammatory targets of SA were screened using protein chip arrays and verified by immunoblotting.

Results:

We found that SA had anti-inflammatory and antioxidant effects in animal and cellular inflammation models. SA inhibited the levels of NO, TNF-α, IL-6, IL-1β, and MDA in tissues and cells and upregulated the expression level of SOD. Animal experiments showed that SA alleviated the shortening of colon length and colon pathological damage caused by DSS. The anti-inflammatory targets of SA were screened using protein chip arrays, and SA was found to inhibit proteins related to the NF-κB signaling pathway. Finally, immunoblotting and immunohistochemistry showed that SA downregulated the expression of p-IKKα/β and its downstream protein p-NF-κB, while promoting the expression of Nrf2 and its downstream protein HO-1.

Conclusion:

The above results indicated that SA alleviated DSS-induced colitis by inhibiting NF-κB signaling pathway and activating Nrf2 pathway.
Antiparkinsonian Potential of Natural Products: Molecular Docking,
Prediction of Pharmacokinetic and Toxicological Properties
Authors: Lima Henrique B. , Ferreira Jaderson V. , Nery Mariela L. , Chaves Gisele A. , da Costa Anderson L. P. , de Souza Lucilene R. , Marino Bianca L. , Brito Maiara F.B. , Teixeira Hueldem R.C. , Silva Carlos H.T.P. , Taft Carlton A. , Hage-Melim Lorane I.S.
Published: September 2022

Background:

Parkinson's disease (PD) is a neurodegenerative pathology common in the elderly, and it may be related to several factors, such as excessive and continuous use of drugs, alcoholism, cerebral ischemia, among others. Emphasizing that there is still no cure for PD, current pharmacological treatment aims to restore reduced dopaminergic activity in the central nervous system and manage symptoms. However, due to the different side effects caused by antiparkinsonian drugs, their use is recommended just when symptoms are considerably impairing professional performance or the patient's daily tasks. Therefore, studies for the development of new drugs have been conducted, and natural products are gaining importance due to the possibility of discovering new bioactive molecular. In this sense, this research aimed to perform the in silico study of molecules of natural origin for the treatment of PD.

Methods:

A search for molecules from medicinal plants was carried out, they underwent a pharmacokinetic and toxicological prediction with subsequent molecular docking study, being coupled with the MAO-B enzyme and the dopamine receptor 2.

Results:

The ginsenosides compounds present an unfavorable pharmacokinetic pattern, which can be explained by their molecular mass, while the other molecules present average patterns, with the exception of kavains, which obtained very satisfactory results. When it comes to toxicity, the molecules curcumin, dihydrokavain, vitexin, kavain and tetrahydrocurcumin did not exhibit any toxic alert. As for the molecular docking study, the compound curcumin stood out with a considerable number of interactions at many amino acid residues relevant to antiparkinsonian activity, both in the MAO-B enzyme and in the D2 receptor.

Conclusion:

Of 25 molecules of natural products, 3 are good candidates for studies of oral drugs, owing to their excellent pharmacokinetic profile and low probability of being toxic. The curcumin molecule has a great notoriety, as it obtained relevant interactions with the two proteins studied in molecular docking, speciallyin the MAO-B enzyme.
An Overview of Paclitaxel and Molecular Imprinted Polymers Capped with Quantum Dots as an Alternative Approach for Paclitaxel Extraction and Detection
Authors: Malik Azad Qayoom , Mir Tahir ul Gani , Kumar Deepak
Published: September 2022

Paclitaxel (Taxol) is a drug that belongs to the class of compounds called Taxane. It is a strong and potent chemotherapeutic drug that inhibits the growth of certain types of cancer cells; however, its abundance is very low, and various types of methodologies have been implemented to extract paclitaxel from the bark of different plants and herbs. The molecularly imprinted polymers (MIPs) could be the best alternative to purify the paclitaxel molecule. MIPs have become an attractive solution for the selective and fine-tuned determination of target templates in complex forms where other comparable and relevant structural compounds could coexist. Implementation of quantum dots in MIPs improves their extraction features due to the presence of distinct functional sites. Quantum dots can be employed to modulate the size, detectability, and state of the imprinted materials, depending on the selected application. This review aims to summarize and illustrate the modern and innovative strategies based on the aggregation of MIPs with quantum dots. Quantum dot embedded MIPs can be exploited for simultaneous extraction, preconcentration, and detection of paclitaxel obtained from various sources.
Intrapleural Thrombolytics for Parapneumonic Effusion: A Network Metaanalysis
Authors: Sridharan Kannan , Sivaramakrishnan Gowri
Published: September 2022

Objectives:

Intrapleural thrombolytics have been trialed for facilitating pleural fluid drainage
in patients with complicated parapneumonic effusion. The present study is a network metaanalysis
of randomized clinical trials (RCTs) that have evaluated these thrombolytics.

Methods:

Electronic databases (Medline, Cochrane CENTRAL, and Google Scholar) were searched
for appropriate RCTs evaluating the therapeutic effect of thrombolytics in patients with complicated
parapneumonic effusion. Mortality, the proportion of patients referred for surgical intervention, and
serious adverse events were the outcome measures. Random-effects model was used for generating
direct and mixed treatment comparison pooled estimates. Grading of the evidence for key comparisons
was carried out. Odds ratio with 95% confidence intervals was used to represent the pooled estimates.

Results:

Seventy-six studies were retrieved with the search strategy, of which 16 were included. No
significant differences were observed in mortality. Compared to normal saline, significantly less proportion
of patients was referred for surgical intervention with streptokinase (0.4, 0.2 to 0.8), urokinase
(0.4, 0.2 to 0.8), alteplase (0.3, 0.1 to 0.7), and alteplase + DNase (0.2, 0.1 to 0.7). DNase alone increased
the risk of referral to surgical intervention (3.4, 1.5 to 7.6). Only streptokinase was observed
with an increased risk of serious adverse events compared to normal saline (2.8, 1.1 to 7.1) and alteplase
(6.7, 1.1 to 39.9). Moderate quality of evidence was observed for streptokinase with normal saline
for the proportion of patients referred for surgical intervention, while either low or very low quality
strength was observed for all other comparisons.

Conclusion:

Streptokinase, urokinase, alteplase, and alteplase + DNase were observed in patients referred
for surgical interventions when used intrapleural in patients with parapneumonic effusion. Alteplase
+ DNase is likely to outperform others as it was observed with the least risk of patients referred
for surgical interventions. Until additional data emerges that changes the pooled estimates,
thrombolytics other than streptokinase are preferred due to the increased risk of serious adverse
events.
Laser Applications in Full Endoscopy of the Spine
Authors: Hellinger Stefan , Yeung Anthony , Tieber Friedrich , Teixeira de Carvalho Paulo Sérgio , Calderaro André Luiz , Lewandrowski Kai-Uwe
Published: September 2022

Lasers have been popular in spine surgery for decades. Patients frequently
ask about laser spine surgery when looking for simplified ways to treat spine pain
related to a herniated disc. Percutaneous interventional non-visualized needle-based
laser treatments have been replaced with visualized endoscopic decompressions. This
chapter reviews the fundamental physics of laser technology applications in spine
surgery. Guidelines for safe laser use in the operating room and avoidance of
complications are discussed in detail. Lasers suitable for spinal decompressions and
their respective tissue interactions are described. The clinical evidence of percutaneous
versus the hybridized use with the visualized endoscopic decompression is examined in
detail.
Uniportal Endoscopic Transforaminal Decompression Associated with Cylindrical Percutaneous Interspinous Spacer
Authors: Cantú-Leal R. , Cantu-Longoria R.
Published: September 2022

Combining the percutaneous transforaminal endoscopic decompression
(PTED) with interspinous process distraction systems (ISP) may offer additional
benefits in treating spinal stenosis in patients who have failed conservative treatment.
We retrospectively investigated the medical records of 152 patients who underwent
transforaminal endoscopic decompression with simultaneous ISP placement through
the same incision. Patients were operated on from January 2008 to June 2016 and
included 80 males, and 72 patients were females. Clinical data analysis was done on
142 patients two years postoperatively since ten patients were lost in follow-up.
Primary outcome measures were pre-and postoperative visual analog scale (VAS)
criteria and the Oswestry Disability Index. Only patients with a minimum follow-up of
2 years were included. The analysis included 224 patients who underwent interspinous
spacers during the transforaminal endoscopic decompression. Of the 152 patients, 84
complained of axial facet-related pain syndromes versus the remaining 68 patients who
chiefly complained of radicular symptoms. The postoperative VAS reduction at two year follow-up for the low back was 6.4. The patient-reported ODI reductions were of a
similar magnitude at 40.4%. According to Macnab criteria, the percentage of patients
who graded their surgical results as excellent or good was 90%. At two-year follow-up,
5 percent of patients required another operation to deal with failure to cure or recurrent
symptoms due to implant subsidence. The authors concluded that adding an
interspinous process spacer to the endoscopic decompression in patients treated for
lateral lumbar stenosis and foraminal stenosis with low-grade spondylolisthesis might
improve clinical outcomes by stabilizing the posterior column.
Cost and Maintenance Management of Endoscopic Spine Systems
Authors: Tieber Friedrich , Hellinger Stefan , Lewandrowski Kai-Uwe
Published: September 2022

Successful implementation of endoscopic spinal surgery programs hinges on
reliable performance and case cost similar to traditional decompression surgeries of the
lumbar spine. Spinal endoscopes used during routine lumbar decompression surgeries
for herniated disc and spinal stenosis should have an estimated life cycle between 150
to 300 surgeries. However, actual numbers may be substantially lower. Abusive use by
surgeons, mishandling by staff, and deviation from prescribed cleaning and sterilization
protocols may substantially shorten the life cycle. Contingency protocols should be in
place to readily replace a broken spinal endoscope during surgery. More
comprehensive implementation of endoscopic spine surgery techniques will hinge on
technology advancements to make these high-tech surgical instruments more resistant
to the stress of daily use and abuse of expanded clinical indications' surgery. The
regulatory burden on endoscope makers is likely to increase, calling for increased
reimbursement for facilities to cover the added expense for capital equipment purchase,
disposables, and the cost of the endoscopic spine surgery program's maintenance. In
this chapter, the authors review such maintenance programs' cornerstones in the current
regulatory environment that one should implement when attempting to run an
endoscopic spinal surgery program at their healthcare facility.
Design of air pressure and height measuring equipment based on Arduino nano using BME280 sensor
Authors: Wibawa I Made Satriya , Putra I Ketut
Published: September 2022

This research has succeeded in designing air pressure and altitude measuring instruments based on arduino nano using BME280 sensor. The design of this tool uses the BME280 sensor as an input for the parameter values ??of air pressure and altitude. The measurement results are displayed on the organic light emitting diode (OLED), which has been processed by the Arduino Nano. Sending measurement results uses the HC-05 module. Calibrate air pressure parameters at the Center for Meteorology, Climatology and Geophysics Region III Denpasar uses the Vaisala PTB 330 digital barometer in the media pressure chamber, while the calibrate the altitude parameter uses Google Earth for reference . The results of the calibration of the two parameters indicate that the design of the measuring instrument has a good level of accuracy, for air pressure of 99.99% and altitude of 99.98%. In addition, the test of the suitability of the OLED output data and the application shows that the data communication has been successful and is in accordance with the match level of 100%.
TYPOLOGY OF PADANG TRADITIONAL HOUSE (RANTAU MINANGKABAU) IN PAUH, PADANG
Authors: Aryanti Desy , S. Nasril , Asmariati Rini , Abd Rashid Mohd Sabrizaa , Mohd Nor Othman
Published: September 2022

The Padang is one part of the Minangkabau Region. According to Tambo Minangkabau, the border of Minangkabau consists of two parts, namely Darek and Rantau. Darek is the origin of Minangkabau which consists of three Luhak/Luhak Nan Tigo namely Luhak Nan Tuo/Tanah Datar, Luhak Nan Tangah/Agam, Luhak Nan Mudo/Luhak Limo Puluh Kota. The region is the expansion area of Minangkabau in the form of each of these Luhak colonies. This research was conducted to explore and find out the origin of the formation of traditional Padang (Rantau Minangkabau) houses, characteristics, spatial patterns, physical forms, and house ornaments. This is a descriptive study including qualitative data. The investigation's goal is to describe the state of the research object and its problems by observing and conducting interviews with homeowners as well as parties who fully understand the existence of this traditional house. As a research case study, the traditional Padang house in Pauh Subdistrict. The results of this study are the identification and typology of traditional houses of the Minangkabau Region.
FINE-GRAINED PARALLELISM FOR POST-PANDEMIC CITIES: 12 DESIGN STRATEGIES FOR RESILIENT URBAN PLANNING
Authors: Wook Seo Kyung
Published: September 2022

The COVID-19 pandemic has changed the way we live in the city. Social distancing will remain as a provisional code of conduct for unforeseeable outbreaks of pandemic diseases in the future. Social distancing is predicated upon reduced density of people in any given space and time. Since urban sprawl has been proved to be unsustainable, spreading out the urban density to suburbs cannot be the right direction to achieve this. Fine-grained parallelism is proposed as a single theoretical framework for an alternative post-pandemic urbanism. It is a way of maintaining simultaneous movement and co-presence, two essential properties of urban living, without the risk of crowding, by reconceptualising the existing spatial setting in a finer resolution. Existing urban spaces that have been underused, ill-used or unused can be reconfigured to achieve fine-grained urbanism for the resilient post-pandemic city.
THE CONSERVATION FRAMEWORK OF HISTORIC INTERIOR SCHEME AS A GUIDELINE FOR FUTURE HERITAGE MUSEUM PLANNING: A CASE STUDY OF ‘RUMAH TEH BUNGA’ IN GEORGE TOWN PENANG
Authors: Abdul Karim Norashikin , Harun Siti Norlizaiha , Ayob Salwa , Hazim Zulkarnain
Published: September 2022

The heritage museum tourism has rapidly grown, contributing the most incometo Government of Malaysia while receiving local and global tourists. SinceMalaysian museums are among the most important tourism assets for the country, they must be given attention, especially the interior spaces of the museum. The interior spaces carry different stories. Due to their own unique historic interior scheme (HIS), different interior features, room functions, spatial designs, historic materials, finishes, and the associated historical events would fill the interior spaces. Unfortunately, the significance of HIS has gradually disappeared due to the exhibitions in the museums. Accordingly, not only the historic integrity in preserving the heritage museum buildings cannot be complied with, but also the significance of the HIS is not highlighted in the exhibition. This study aimed to propose a HIS conservation framework as a guideline for preserving the historic scheme of museum building interior. The evaluation method was used to measure the HIS and HES of the interior space of the museum. ‘Rumah Teh Bunga’ also known as the Penang Malay Gallery in George Town Penang has been selected for the case study. Hopefully, the HIS framework would inform the museum bodies to make the interior spaces of the museum more memorable for tourists.
LANDSCAPE AND PLANTS PROFILE ANALYSIS IN RURAL PERAK
Authors: Mohd Hussain Nur Huzeima , Mat Nayan Nadiyanti , Ahmad Suriati , Salleh Ismail Hafiz
Published: September 2022

Landscape and plants portrayed the evolution and development of the society through culture, local identity, and sustainability. The plants' evolution is perceptible and measurable to be examined and documented for future reference. Therefore, this study aims to examine the changes in plant selection through plant profile illustration. The illustration is based on data collection and secondary evidence between the years 2010 to 2020, in Perak Tengah. The objectives are to analyse plants profile associated with society's needs and impacts on the landscape setting. This paper ventures on the historical settings of plants in Rumah Kutai, evolution in contemporary and in the commercial the landscape through the plant height profile to evaluate the personal needs, economical influences, and self-resilience. This paper concludes the evolving role and profile of the home landscape, from logistic to holistic pursuing the physical, spiritual and economical needs of the local community and planning agenda in the 21st century.
THE ASSESSMENT ON KAMPUNG KUBU, TANJUNG MALIM, PERAK AS A HERITAGE VILLAGE
Authors: Ahmad Badri Nur Faizah , Ramli Rohaslinda Ramele
Published: September 2022

The conservation of heritage villages in Malaysia seems to receive more attention from government and private organizations. However, the assessment guidelines are still unclear, and urban development tends to ignore these historical settlements. This study aims to assess Kampung Kubu, a historical settlement in Tanjung Malim, Perak, by discussing its potential as a heritage village. The study focuses on heritage significance based on the criteria used for heritage village assessment in other states. Descriptive data is obtained from reviews on historical documents and articles, field observation, and interviews with the village and local authority representatives. The findings showed that Kampung Kubu displays strong evidence in the historical aspect, based on the traditional houses, historical landmarks, weaponry, and proper documented historical records. Therefore, it is recommended for this village to be developed for heritage tourism to support its recognition as a heritage village as a part of the urban development.
ASSESSING A CONDITION OF TIMBER DEFECT FOR PERAK TRADITIONAL MALAY’S ARCHITECTURE: AN INITIAL STEP TO CREATING ENTITY RELATIONSHIP (ER) MODEL IN DATABASED MANAGEMENT SYSTEM (DBMS)
Authors: Bahardin Nur Fadhilah , Baharuddin Mohd Nurfaisal , Azman Muhammad Azrul Azwan , Bakhari Mohamad Khairul Al Hafiz , Abd Rashid Mohd Sabrizaa
Published: September 2022

The significance value of Traditional Malay’s House is relying on its architecture and strength ability of timber building and reflect the cultural value to the society. The uniqueness of this house is on the use of timber material such as Meranti, Jati and Chengal which prominent as a robust, long lasting and not easy to deteriorate spontaneously. Numerous factor that affects to the timber material and make it deteriorate can possibly cause by external forces, biological agents, temperature and the poor standard of workmanship. An existing information is very crucial in a way to ‘boost up’ locality economy especially in the aspect of heritage tourism. Local authorities as an administrative agency can play an important role as an ‘information provider’ to the ministry in promoting the tourism sector if they have a comprehensive database. The primary issue of tourism data is no comprehensive information about the traditional Malay house at respective administrative area in terms of building performance as well as defect analysis as to ensure a sense of historical place is preserved successfully. The aim of this paper is to develop Databased Management System for Perak Traditional Malay’s House based on defect pattern at eleventh (11) nos. of Perak which focusing on Rumah Limas Bumbung Perak. Based on that analysis, it can be summarized that defect which often attacked a timber building, especially in tropical country especially in Malaysia was mainly caused by moisture problems and biological attack. A continuous exposure to these environmental agents and pests without proper maintenance and care with preventive measures will speedily decayed the buildings materials especially timber. Therefore, this paper is intended to explore a possibility of building condition assessment activity towards a data creation for database management system by exploitation a benefit of geographical information system (GIS).
THE APPLICATION OF GREEN ADAPTIVE REUSE OF HISTORICAL BUILDINGS IN UNESCO CITIES
Authors: Alauddin Kartina , Mohd Nusa Fatin Najwa , Baharuddin Mohd Nurfaisal , Abdul Rashid Mohd Sabrizaa , Remeli@Ramli Rohaslinda
Published: September 2022

Adaptive reuse can help increase operating efficiency, and "green adaptive reuse" is the best option for historical buildings. There are no specific important environmental elements in the Malaysia Green Building Index (GBI) that are catered for, particularly for the reuse of historical buildings in the Malaysian setting. There is a vital need to identify certain essential environmental aspects that can be used to develop green features in Malaysia's adaptive reuse projects. This study examines the perspectives of adaptive reuse practitioners who have worked on historical building adaptive reuse projects through semi-structured interviews. These findings may assist GBI Malaysia in strengthening by identifying the fundamental environmental aspects for green adaptive reuse and classifying and sorting the elements into major categories in a meaningful sequence compatible with historical connections, sustainable and city planning knowledge.
EVALUATION OF SOCIAL IMPACT ASSESSMENT (SIA) PRACTICES USING SWOT ANALYSIS: A CASE STUDY IN INDIA
Authors: Ahmad Khairi Ameera Nazeerah , Ponrahono Zakiah , Sahrir Syazwani
Published: September 2022

Social Impact Assessment (SIA) has been incorporated into part of EIA legislative structures in most nations following the adoption of the National Environmental Policy Act (NEPA) in the USA. The assessment acts as a policy instrument for evaluating a project’s socio-cultural consequences and for advising socio-political stakeholders on its social viability. The instrument also provides operational advice for tackling any negative social effects the policy could have, with a focus on improving its positive effects. However, the traditional SIA has been deemed insufficient for measuring social consequences and has received little emphasis in the appraisal process compared to economic and environmental impacts. Two case studies and a SWOT analysis were conducted to analyse and compare the Social Impact Assessment (SIA) by using a matrix analysis. The findings indicate that both case studies have similar indicators to each term that integrates with one another. The focus on the term is weaknesses, particularly during the redevelopment of a report, which is still lacking in many ways.
EXPLORING RISK PERCEPTION AND INTENTION TO IMPROVE THE AIR QUALITY
Authors: Sahrir Syazwani , Yalçınkaya Nermin Merve , Say Nuriye
Published: September 2022

Numerous environmental issues, particularly those with higher risks, have steadily come to the forefront of the public's concerns in recent years with the increased awareness on environmental quality. For example, air pollution is one of the main causes of death worldwide and contributes to the rise in the risk of chronic diseases. In the Turkish city of Adana, air pollution has long been recognised as a serious environmental and health concern with well-documented negative consequences on human wellbeing. Although important, little is known about how the general public views the risk of air pollution. Thus, this paper focuses on risk perception and behavioural intention to air pollution. Adana city in southern Turkey was chosen as the study area. The results showed that sociodemographic factors and perceived risk of familiarity with air pollution are significant factors influencing Adana inhabitants' willingness to pay for bettering the air quality. Additionally, it implies that the authority might provide a significant contribution by creating strategies to lessen the effects of air pollution on people, particularly in cities where air pollution is a problem.
INVESTIGATING OVERTOURISM IMPACTS, PERCEIVED MAN-MADE RISK AND TOURIST REVISIT INTENTION
Authors: Azinuddin Muaz , Mat Som Ahmad Puad , Mohd Saufi Siti ‘Aisyah , Zarhari Nurul Ain Atiqah , Wan Mohd Amin Wan Abd Aziz , Mior Shariffuddin Nur Shahirah
Published: September 2022

This research explores the interrelationships between overtourism impacts, perceived man-made risk and revisit intention among tourists visiting Melaka UNESCO World Heritage Site (WHS). The aim of the study is to illustrate the overutilization of destination resources and subsequent human risk that shape tourist behavioural from the outlooks of sustainable and tourism impacts. Five hundred and ninety-three responses were quantitatively collected through an online data collection. Partial least square structural equation modelling (PLSSEM) is employed to investigate the research hypotheses. It can be reported overtourism impacts have positive and significant influence on the perceived man-made risks. However, this is not the case for the relationship between overtourism impacts on revisit intention, and the perceived man-made risk on the latter construct. This renders the potential mediation role of perceived man-made risk as insignificant. The findings heighten the unique dynamics of overtourism within developing WHS planning in shaping tourist revisit intention.
LOCAL COMMUNITY PERSPECTIVE ON RESPONSIBLE TOURISM AND DESTINATION SUSTAINABILITY
Authors: Mohd Rasdi Aikal Liyani , Mat Som Ahmad Puad , Azinuddin Muaz , Muhamad Nasir Muhamad Nasyat , Abd Hadi Khan Nur Farihin
Published: September 2022

The tourism industry has relied on long-term planning and is anticipating growing availability and demand for socially, ecologically, and economically responsible tourism. As a novel idea, responsible tourism practices may boost efforts for sustainable tourism development, improving the image and competitiveness of tourism destinations. The purpose of this research is to look at the link between responsible tourism and destination sustainability in Cameron Highlands communities. This study employed descriptive research and a cross-sectional design. In order to complete the study, questionnaires were handed to local communities in three (3) Cameron Highlands sub-districts: Ulu Telum, Tanah Rata, and Ringlet. According to correlation and regression tests, the study found a significant relationship between responsible tourism and destination sustainability. As a result, destination sustainability necessitates a greater emphasis on the development of environmental consciousness, sustainable livelihood, and community well-being. Because local communities are a component of the tourism experience, the study findings can help tourism stakeholders execute tourism development plans based on local community views and quality of life.
Use of a Mobile App for the Process Evaluation of an Intervention in Health Care: Development and Usability Study (Preprint)
Authors: Ombong Deva Indri Saputri
Published: September 2022

BACKGROUND

The world calls for increased access and maternal and child health services. This is in line with the global targets contained in the 2030 Sustainable Development Goals (SDGs), namely to eliminate all forms of malnutrition in children under five, adolescent girls, pregnant and lactating mothers, and the elderly. One way is to increase access to personal health data so that patients know the importance of monitoring their health. Therefore, it is necessary to develop applications for personal health records of mothers and children to support the achievement of the SDGs targets by 2030.

OBJECTIVE

This paper aims to design and build a mobile-based application for personal health records for maternal and children.

METHODS

This design phase uses the waterfall method during the product evaluation. Requirement analysis based on the data collected with interviews, observations, and literature studies, then product evaluation using the System Usability Testing (SUS) method.

RESULTS

This design produces a Unified Modeling Language (UML) design consisting of use cases and activity diagrams, a user interface design, and a maternal and child personal health record application named SIKIA (Maternal and Child Health Application). This design also creates the final product evaluation result, which states that the SIKIA application can easily accept by the user (acceptable).

CONCLUSIONS

The design of the mobile-based mother and child personal health record application has been approved and is by user needs.
Real-world evidence on the uptake, barriers and associated factors with targeted therapy among metastatic colorectal cancer patients in China: A multi-center, cross-sectional survey (Preprint)
Authors: Liu Jr Yin , Zhang Xi , Xu Hui-Fang , Shi Ji-Hai , Zhao Yu-Qian , Du Ling-Bin , Liu Yun-Yong , Wang Wen-Jun , Cao He-Lu , Ma Li , Huang Juan-Xiu , Cao Ji , Li Li , Fan Yan-Ping , Gu Xiao-Fen , Feng Chang-Yan , Zhu Qian , Wang Xiao-Hui , Du Jing-Chang , Zhang Jian-Gong , Zhang Shao-Kai , Qiao You-Lin
Published: September 2022

BACKGROUND

Targeted therapy represents an effective modality for metastatic colorectal cancer (mCRC) with substantial health benefits. Targeted agents for mCRC have been approved for over a decade. However, little is known about their application in real-world clinical practice.

OBJECTIVE

We aimed to explore the uptake of targeted therapy and determine barriers and factors associated with initiating targeted therapy among Chinese mCRC patients.

METHODS

A cross-sectional, multi-center, hospital-based survey was conducted in China, from March 2020 to March 2021. mCRC patients who had finished at least one cycle of chemotherapy were enrolled from nineteen hospitals in fourteen cities through stratified, multistage cluster sampling. Descriptive analyses were used to report patients' characteristics, distribution on the timing and kinds of targeted agents first time used, and barriers against targeted therapy. Logistic regressions were conducted to assess the factors associated with initiating targeted therapy.

RESULTS

A total of 1,688 mCRC patients were included. Slightly over half the patients (51.6%, 871/1,688) have initiated the targeted therapy, of whom, 44.5% (388/871), 20.2% (176/871), and 35.2% (307/871) first initiated as the first-line, second-line, and third-line therapy, respectively. Bevacizumab was most frequently used (68.4%, 596/871). Unaffordable medical costs (41.6%, 340/817), not convinced that targeted therapy works (30.8%, 252/817) and fear of side effects (17.3%, 141/817) were the most reported barriers against targeted therapy. Patients treated in the general hospital, and with lower level of education, less annual family income, no medical insurance, poor health-related quality of life prior to the first treatment of mCRC, metastasis outside liver/lung or systemic metastasis, a duration of mCRC<10 months were unlikely to initiate targeted therapy, while patients located in North China and having both liver and lung metastasis were likely to.

CONCLUSIONS

This study highlights the limited uptake of targeted therapy, and frequent delayed treatment and misuse of targeted agents among mCRC patients in China. Reducing the costs, and interventional education on improving public awareness were recommended to facilitate the application of targeted therapy.