bluuebunny/crossref_metadata_2025 huggingface dataset:
SHEELA-NA-GIG: FEMINISMO ESTÉTICO ANCESTRAL E SEU REFLEXO NAS EXPRESSÕES ARTÍSTICAS CONTEMPORÂNEAS
Authors: Linhares Isabele
Published: February 2024

A ideia do Feminino muda no decorrer do tempo, inspira movimentos, conflitos, revoluções e tem muito a revelar sobre realidades socioculturais e polí­ticas de um povo. O campo da arte traz numerosas representações dessas diferentes realidades e registros de narrativas persistentes como o binarismo, biopoder e sexualidades. As Sheela-na-gig, representações europeias medievais de genitais femininos em pedra, podem ser vistas como expressões da percepção do corpo feminino e do valor simbólico atribuí­do por povos medievais europeus. As peças em questão, produzidas por quatro séculos, conectam a cultura pagã e cristã e as fases históricas do pensamento ocidental no que se referem ao corpo, sexo, crenças e subjetividades. O presente artigo parte da análise destas imagens medievais até às expressões artí­sticas contemporâneas remetendo esta discussão à relevância da questão do Feminino nas atuais ressignificações de gênero.
EMOLDURAR-SE NO OUTRO: UMA ANÁLISE DAS RIMAS VISUAIS EM AS PRAIAS DE AGNÈS
Authors: Oleinik de Moraes Natacha
Published: February 2024

Considerando a relação entre a cineasta Agnès Varda e seu modo de fazer cinema, objetiva-se analisar o filme As Praias de Agnès (2008) a partir das diversas molduras encontradas no filme, consideradas como motivo, paralelismos, ou rimas visuais desta obra, na definição de Bordwell e Thompson (2013). Através desta análise de seu filme-memória, é possí­vel delinear sua criação fí­lmica, a qual parte de suas vivências entrelaçadas ao seu ato de filmar, até o processo de (auto)transformação que ocorre ao longo seus filmes, caracterizando assim, de certa forma, sua própria definição de cinescritura (VARDA, 1994). Desse modo, observa-se que essas molduras sinalizam a busca da cineasta por uma outra maneira de emoldurar a si mesma sempre considerando sua relação com o outro, - seja este seus personagens , sua equipe, ou até seus espectadores - subvertendo enquadramentos e construindo outros contornos de visibilidade para, assim, mirar outros modos do viver.
DIANTE DO EXISTIR: DANÇANDO A DECOLONIALIDADE
Authors: Rosa Vitor Cardoso da , Cálipo Nara
Published: February 2024

O presente trabalho apresenta o processo artí­stico e investigativo nomeado "Diante do Existir" , objetivando instaurar uma discussão acerca da colonialidade na dança. O trabalho apresenta como hipótese um caminho possí­vel para a decolonialidade do movimento do corpo que dança, cria e investiga. Tal caminho situa-se na imersão na grafia do corpo, esta como deflagradora da colonialidade ao expor memórias, traumas e demais inscrições corporalizadas. Para tanto é assumida a oposição às concepções inerentes às práticas epistêmicas eurocêntricas ou responsáveis pela manutenção da colonialidade do saber. Neste sentido, tanto a perspectiva teórica como a empí­rica foram enfatizadas e consideradas para o desenvolvimento e estruturação deste trabalho.
O CU-ESPORPIÃO DE BRUNA KURY COMO ARTIVISMO DESCULONIZATÓRIO CUIR
Authors: Colin Daniel dos Santos
Published: February 2024

O presente texto configura-se como uma reflexão revisitada de um subcapí­tulo exclusivo da minha tese de Doutorado em Teatro (PPGT-UDESC), intitulada ""˜O sul do corpo é o nosso norte': práticas deCUloniais em corpos de artistas brasileir*s" (2019). O artigo reporta-se à análise crí­tica-decolonial de duas performances da faca produzidas e executadas pela artista brasileira Bruna Kury respectivamente na Cidade do México (México) e no Rio de Janeiro (RJ-Brasil) em 2017. Como uma performer travesti, negra e marginalizada, Bruna se propõe a desestabilizar a cisheteronormatividade por meio de tais realizações cênicas disruptivas e provocadoras, tratadas aqui como exemplos de um possí­vel "artivismo desCUlonizatório CUir" , uma categoria artí­stica fluida e sem pretensões classificatórias. Ademais, o artigo expõe alguns dos meios pelos quais o neologismo CUir se apresenta como uma perspectiva polí­tica situada geohistoricamente na América Latina em detrimento das assimilações acadêmicas e higienistas da teoria queer estadunidense em nosso território, e ainda se refere às práticas teóricas e empí­ricas desenvolvidas por sujeitos sudakos das dissidências sexuais e de gênero.
Do acaso ao iní­cio: notas autobiográficas como observação do processo mental da conceituação de uma obra audiovisual (e suas referências)
Authors: Silva Daniel Rojas
Published: February 2024

A partir de um olhar autobiográfico, investigamos acontecimentos e referências de variadas fontes que se referem e cruzam minha vida na conceituação de obra audiovisual em processo de criação denominada "˜190_lfa'. Este trabalho concatena conceitos gerais e artí­sticos como direcionamento no momento de sua criação: documentário poético e ruí­nas, música ambiente e paisagem sonora, percurso. Partindo das notas aqui compartilhadas, relacionamos obras artí­sticas, conceitos e situações a fim de identificar as tangências entre tais elementos que levaram ao conceito do referido trabalho. Ao mesmo tempo podemos observar os traços da gênese de um trabalho artí­stico partindo das percepções de seu criador. Para tal observação, recorremos à Fayga Ostrower ao associar os acasos significativos à criação artí­stica e à Cecí­lia Salles juntamente de seus dispositivos e conceituações referentes ao processo criativo. Tendo em vista que o perí­odo prévio à criação de uma obra de arte também se caracteriza como parte do percurso de criação.
ENTRE DISCURSO E OBJETO: ESTÉTICA COMO POLÍTICA NA RESSIGNIFICAÇÃO DE MONUMENTOS PÚBLICOS A PARTIR DA AÇÃO ENSACAMENTO (3NÓS3, 1979)
Authors: Paris Gustavo Candido de Jesus
Published: February 2024

O presente artigo visa discutir a ressignificação de monumentos públicos através da arte a partir da intervenção Ensacamento (1979), do coletivo paulista 3nós3. Para tanto, parte-se de uma breve contextualização que objetiva, de um lado, descrever o papel do monumento nas cidades capitalistas e, de outro, apresentar a origem do grupo como parte de um movimento nacional de retomada do espaço público no fim do regime militar. Como gênero artí­stico, a ação será analisada segundo as noções de site-specificity, abordadas pela autora Miwon Kwon, mostrando que a relação da poética com o site em sua dimensão discursiva é capaz de tensionar o lugar a partir de convergências com o discurso pré-existente no local, revelando memórias apagadas pela história hegemônica. Do discurso, a ação passa por um processo de rematerialização, hipótese defendida neste artigo na forma de criação de um novo objeto, produto da intervenção sobre o conjunto de estátuas, efêmero no espaço-tempo da ação e perpétuo a partir de seu registro. Dessa leitura emerge a relação estética entre arte e polí­tica à luz da teoria de Jacques Rancière, com o objetivo de mostrar que a estátua ensacada se configura como uma promessa no processo de autonomia da experiência sensí­vel. Por fim, será destacado como a ressignificação dos monumentos públicos se manifesta nos diferentes atos da ação, mostrando que existe uma estética primeira nas estátuas antes e depois da intervenção.Palavras-chave: Ensacamento; estética; site-specificity.
Lady Gaga e a identidade através da religiosidade armênia em 911
Authors: Martins Natasha , Bogossian Gabriel
Published: February 2024

Lady Gaga é uma das mais influentes artistas da atualidade, conhecida por retratar em suas performances temas polêmicos, destacando-se os cunho religioso e espiritual. Buscou-se por meio de análise do videoclipe de autoria da artista chamado 911 em intersecção com a obra cinematográfica a qual lhe serviu de inspiração estética, A Cor da Romã, o diálogo acerca dos símbolos ligados à religiosidade armênia. Diante da histórica problemática que envolve a Armênia como um país autônomo e possuidor de uma identidade, sua expressão por meio da linguagem pop levanta questões sobre apropriação e/ou aproximação cultural.
Criar espaços de conversação
Authors: Vilasboas Slomp Sofia , Pereira Sayonara
Published: February 2024

Este texto traz um olhar sobre a exposição “Retrospectiva” de Xavier Le Roy (2012), do coreógrafo francês Xavier Le Roy, que foi criada a partir de solos do artista, que são reativados pelos dançarinos-colaboradores construindo uma ligação entre a retrospectiva pessoal do coreógrafo e a história da/na dança vivida por cada dançarino. A criação de um espaço de conversação ocorre, entre outros, pelo endereçamento direto ao visitante que testemunha as memórias e narrativas produzidas pelos artistas no espaço social do museu.
Memorial descritivo de laboratórios exploratórios da interatividade entre música e dança em contextos de improvisação livre
Authors: Clarindo Nunes Luam Gabriel
Published: February 2024

Pretende-se, neste memorial descritivo, relatar e comentar a experiência de três laboratórios de interação entre música e dança, realizados entre maio e junho de 2022. O objetivo principal desses laboratórios foi experimentar diferentes propostas de interação entre música e dança em sessões de improvisação livre. Os laboratórios aconteceram no Teatro Laboratório (Telab) da Faculdade de Artes do Paraná (FAP), em Curitiba, em encontros do grupo de dança UM (Núcleo de Pesquisa Artística em Dança da Universidade Estadual do Paraná – Unespar) e contaram com a participação dos integrantes do grupo e musicistas selecionados. Visando à vivência de diferentes configurações de interações entre música e dança, foram criados cartões para improvisação baseados em níveis distintos de interação entre gestualidade corporal e musical (sintonia, sincronia e empatia), propostos pelo musicólogo Marc Leman. O conteúdo deste memorial descritivo integra a pesquisa de mestrado Movimento – Som: uma investigação sobre interações entre música e dança em processos de improvisação livre, que está em andamento, na linha de criação sonora do Programa de Pósgraduação em Música do Departamento de Artes da Universidade Federal do Paraná (UFPR).
Corpo, cognição e tecnologia: as potencialidades no processo de criação em dança remota no UM
Authors: Lorena de Oliveira Larissa
Published: February 2024

O artigo em questão discute sobre as relações de corpo, cognição e tecnologia e como estas relações se refletiram no processo de criação e improvisação em dança, no ano de 2021, dentro do grupo de extensão UM – Núcleo de Pesquisa Artística em Dança da Unespar. Como aporte teórico o texto apresenta de forma breve conceitos importantes sobre enação NOE (2004) para compreender melhor os processos de percepção; a teoria Corpomídia (KATZ; GREINER, 2005) para o entendimento do papel ativo do corpo na aquisição de conhecimento; bem como da relação contínua com o ambiente neste processo. Salienta-se também que este processo é atravessado pelas relações entre tecnologia e cognição (CLARK, 2003, 2009) (SIEDLER, 2016). Entendendo o corpo como propositor (SILVA, 2013), que se relaciona com o ambiente e com os aparatos tecnológicos, apresenta-se as percepções da autora sobre a vivência no processo de criação em dança ao longo do ano de 2021, nos encontros remotos propostos pelo UM.
The mechanism of gut-lung axis in pulmonary fibrosis
Authors: Dong Yawei , He Lanlan , Zhu Zhongbo , Yang Fan , Ma Quan , Zhang Yanmei , Zhang Xuhui , Liu Xiping
Published: February 2024

Pulmonary fibrosis (PF) is a terminal change of a lung disease that is marked by damage to alveolar epithelial cells, abnormal proliferative transformation of fibroblasts, excessive deposition of extracellular matrix (ECM), and concomitant inflammatory damage. Its characteristics include short median survival, high mortality rate, and limited treatment effectiveness. More in-depth studies on the mechanisms of PF are needed to provide better treatment options. The idea of the gut-lung axis has emerged as a result of comprehensive investigations into the microbiome, metabolome, and immune system. This theory is based on the material basis of microorganisms and their metabolites, while the gut-lung circulatory system and the shared mucosal immune system act as the connectors that facilitate the interplay between the gastrointestinal and respiratory systems. The emergence of a new view of the gut-lung axis is complementary and cross-cutting to the study of the mechanisms involved in PF and provides new ideas for its treatment. This article reviews the mechanisms involved in PF, the gut-lung axis theory, and the correlation between the two. Exploring the gut-lung axis mechanism and treatments related to PF from the perspectives of microorganisms, microbial metabolites, and the immune system. The study of the gut-lung axis and PF is still in its early stages. This review systematically summarizes the mechanisms of PF related to the gut-lung axis, providing ideas for subsequent research and treatment of related mechanisms.
Understanding sentiment toward racial unrest through temporal and geographic lenses: a multilevel-analysis across metropolitan areas in the United States
Authors: Lee Sanguk , Cho Myung Sik , Peng Tai-Quan
Published: February 2024

Racial unrest has long been a salient social issue in the United States. Time and space provide essential contexts for the emergence and evolution of racial unrest. However, the relationships between these contextual factors and public responses to racial unrest remain insufficiently explored. This study seeks to fill that gap, blending geocoded, time-stamped racial unrest tweet data with census information. It aims to explore how temporal elements and geographical characteristics of metropolitan areas contribute to the emergence of negative sentiment reactions to racial unrest on social media platforms. The racially charged unrest that transpired in Ferguson, Missouri in 2014 serves as our case study. We select 33 metropolitan regions across the U.S. for our analysis. Our findings indicate that temporal processes, encompassing circadian rhythms, weekday-weekend variations, and temporal decay, correlate with expressions of anxiety and anger, albeit not sadness. Furthermore, our analysis reveals geographical characteristics—notably income inequality and segregation, combined with the number of Black victims—to be associated with manifestations of anxiety.
The cardiomyopathy of cystic fibrosis: a modern form of Keshan disease
Authors: Segovia-Cubero Javier , Ruiz-Bautista Lorena , Maiz-Carro Luis , Girón-Moreno Rosa M. , Prados-Sánchez M. Concepción , Martínez-Martínez M. Teresa , González-Estecha Montserrat , Mingo-Santos Susana , Gómez-Bueno Manuel , Salas-Antón Clara , Cavero-Gibanel Miguel A. , Pastrana-Ledesma Miguel , García-Pavía Pablo , Laporta-Hernández Rosalía , Sánchez-Ortiz David , Alonso-Pulpón Luis
Published: February 2024

Introduction

We conducted a study to determine the prevalence of structural heart disease in patients with CF, the characteristics of a cardiomyopathy not previously described in this population, and its possible relationship with nutritional deficiencies in CF.

Methods

We studied 3 CMP CF patients referred for heart-lung transplantation and a prospective series of 120 adult CF patients. All patients underwent a clinical examination, blood tests including levels of vitamins and trace elements, and echocardiography with evaluation of myocardial strain. Cardiac magnetic resonance imaging (CMR) was performed in patients with CMP and in a control group. Histopathological study was performed on hearts obtained in transplant or necropsy.

Results

We found a prevalence of 10% (CI 4.6%–15.4%) of left ventricular (LV) dysfunction in the prospective cohort. Myocardial strain parameters were already altered in CF patients with otherwise normal hearts. Histopathological examination of 4 hearts from CF CMP patients showed a unique histological pattern of multifocal myocardial fibrosis similar to Keshan disease. Four of the five CF CMP patients undergoing CMR showed late gadolinium uptake, with a characteristic patchy pattern in 3 cases (p < 0.001 vs. CF controls). Selenium deficiency (Se < 60 µg/L) was associated with more severe LV dysfunction, higher prevalence of CF CMP, higher NTproBNP levels, and more severe pulmonary and digestive involvement.

Conclusion

10% of adults with CF showed significant cardiac involvement, with histological and imaging features resembling Keshan disease. Selenium deficiency was associated with the presence and severity of LV dysfunction in these patients.
Molecular effects of cardiac contractility modulation in patients with heart failure of ischemic aetiology uncovered by transcriptome analysis
Authors: Lyasnikova E. , Sukhareva K. , Vander M. , Zaitsev K. , Firulyova M. , Sergushichev A. , Sorokina M. , Trukshina M. , Galenko V. , Lelyavina T. , Mitrofanova L. , Simonova K. , Abramov M. , Faggian G. , Luciani G. B. , Lebedev D. S. , Mikhaylov E. N. , Sitnikova M. , Kostareva A.
Published: February 2024

Cardiac contractility modulation (CCM) is based on electrical stimulation of the heart without alteration of action potential and mechanical activation, the data on its fundamental molecular mechanisms are limited. Here we demonstrate clinical and physiological effect of 12 months CCM in 29 patients along with transcriptomic molecular data. Based on the CCM effect the patients were divided into two groups: responders (n = 13) and non-responders (n = 16). RNA-seq data were collected for 6 patients before and after CCM including 3 responders and 3 non-responders. The overall effect of CCM on gene expression was mainly provided by samples from the responder group and included the upregulation of the genes involved in the maintenance of proteostasis and mitochondrial structure and function. Using pathway enrichment analysis, we found that baseline myocardial tissue samples from responder group were characterized by upregulation of mitochondrial matrix-related genes, Z disc-protein encoding genes and muscle contraction-related genes. In summary, twelve months of ССM led to changes in signaling pathways associated with cellular respiration, apoptosis, and autophagy. The pattern of myocardial remodeling after CCM is associated with initial expression level of myocardial contractile proteins, adaptation reserves associated with mitochondria and low expression level of inflammatory molecules.
Effect of 10-year cumulative blood pressure exposure on atherosclerotic cardiovascular disease of different age groups: kailuan cohort study
Authors: Guo Lu , Tian Faming , Wang Jingyao , Xu Wenqi , Li Wenjuan , Hou Xiaoli , Zheng Mengyi , Yang Xuemei , Gao Lishu , Chen Shuohua , Zhang Nan , Wu Shouling
Published: February 2024

Background

The level at which cumulative blood pressure (BP) can increase the risk of ASCVD in different age groups remains unclear. This study aimed to investigate the association of 10-year cumulative BP levels with the long-term risk of ASCVD of different age groups.

Methods

Cumulative BP exposure was assessed using the time-weighted average (TWA) BP divided into four BP groups. The participants were also divided into four groups according to their baseline age (<50, 50–59, 60–69, or ≥70 years). The association between TWA BP and the risk of ASCVD was assessed by age group using multivariate Cox models. The China-PAR prediction model was used to assess the ability of TWA BP to predict ASCVD.

Results

In the group aged <50 years, the hazard ratios and 95% confidence intervals for the risk of ASCVD were 2.66 (1.04–6.80), 3.38 (1.54–7.43), and 3.13 (1.36–7.24) for the elevated BP, stage 1 hypertension, and stage 2 hypertension groups, respectively, when compared with the normal BP group. There was a significant difference in the risk of ASCVD between the age groups, with participants aged <50 years having the highest risk, followed by those aged 50–59, 60–69, and ≥70 years.

Conclusions

The risk of ASCVD with high cumulative BP exposure was age-dependent, with a gradual decrease in risk with increasing age.
Complexity of coronary artery disease and the release of cardiac biomarkers after CABG
Authors: Pölzl Leo , Lohmann Ronja , Sterzinger Philipp , Nägele Felix , Hirsch Jakob , Graber Michael , Engler Clemens , Eder Jonas , Abfalterer Hannes , Ulmer Hanno , Griesmacher Andrea , Grimm Michael , Bonaros Nikolaos , Ruttmann-Ulmer Elfriede , Holfeld Johannes , Gollmann-Tepeköylü Can
Published: February 2024

Objective

In patients with complex coronary artery disease (CAD) undergoing cardiac surgery, myocardial protection might be impaired due to microvascular obstruction, resulting in myocardial injury and subsequent biomarker release. Therefore, this study investigated the correlation between the complexity of CAD, reflected by the SYNTAX Score, and the release of cardiac biomarkers after CABG.

Methods

In a consecutive series of 919 patients undergoing isolated CABG SYNTAX scores I and II were calculated to assess the complexity of CAD. Levels of high sensitivity cardiac troponin T (hs-cTnT) and creatine kinase-myocardial band (CK-MB) were routinely measured once before and serially after surgery. Patients were divided into tertiles according to their SYNTAX Scores I and II. Spearman correlations and regression models were performed to measure the degree of association between the release of hs-cTnT and CK-MB and the SYNTAX Scores.

Results

Patients with a higher SYNTAX Score I had more comorbidities reflected in a higher EuroSCORE II. Preoperatively, higher levels of cardiac biomarkers were found in patients with higher SYNTAX Score II. No correlation was observed between hs-cTnT, CK-MB and SYNTAX Score I or II. Regression models did not show any association between cardiac biomarkers and the complexity of CAD.

Conclusion

The complexity of CAD is not associated with the release of cardiac biomarkers after CABG. Factors influencing postoperative biomarker release need to be elucidated in future trials to include postoperative biomarker release into risk stratification models predicting outcome after cardiac surgery.
Structural vibration characteristics of the historical building in a nearby blasting test
Authors: Ren Yunsen , Xi Shujuan , Yang Yuhang , Wan Tao , Wang Haiyan , Zhao Kai
Published: February 2024

The tunnel construction by the drill-and-blast method can have a significant impact on the adjacent buildings, especially the historical buildings with poor structural performances. Based on a special explosive case of Nanjing Metro Line 4, an in-situ blasting test for vibration safety evaluation on the Nanjing Drum Tower was carried out. According to the site geological investigation, the location of the blasting test was selected near the planned tunnel. 6 blasting was carried out in terms of sing-hole blasting and millisecond-delay blasting. The attenuation of the ground vibration and the structural vibration responses of the historical Drum Tower were analyzed. The test results also showed that the Nanjing Drum Tower was not damaged by this blasting test. For single-hole blasting tests, the peak particle velocity increased with the increasing of the explosive charge, but decreased remarkably when using the millisecond-delay blasting technology. The horizontal and vertical ground vibration attenuation patterns were consistent, which can be described by the Sadowski formula. The ground vibration response was dominated by the horizontal vibration, and the velocity amplification factor in the case of the single-hole test with a charge quantity of 400 g reached 2.4, which was observed the most remarkable amplification effect.
The association of Life’s Simple 7 and infertility among U.S. women
Authors: Wang Lixia , Chang Guangting , Cai Shu , Zou Xiaofang , Qin Meijiao , Tan Yingyao
Published: February 2024

Background

The Life’s Simple 7 (LS7) metric is a comprehensive measure of cardiovascular health (CVH) that encompasses seven distinct risk factors and behaviors associated with cardiovascular disease (CVD). Some studies have shown an association between infertility and CVD. The present study aimed to explore the potential association between the LS7 factors and infertility.

Methods

A cross-sectional study was conducted on a sample of 3537 women aged 18-44 years from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2013-2018. The LS7 metrics encompassed various factors including physical activity, smoking habits, body mass index, blood pressure levels, dietary patterns, blood glucose levels, and total cholesterol levels. We computed a 14-point LS7 score based on participants’ baseline data, classifying them as “inadequate” (3-6), “average” (7-10), or “ideal” (11-14). Infertility is defined as an affirmative answer to either of two questions on the NHANES questionnaire: “Have you tried to conceive for at least one year without success?” and “Have you sought medical help for your inability to conceive?” Logistic regression was utilized to estimate odds ratios (O.R.s) and 95% confidence intervals (C.I.s).

Results

In total, 17.66% of participants were classified as individuals who reported experiencing infertility. In the continuous analysis, each one-unit increase in LS7 score was associated with a significantly decreased odds of infertility (OR=0.88 [0.77-0.89]). Analyzing the categorical representation of LS7 score, compared to individuals with poor scores, those with ideal scores exhibited a substantial 58% reduction in the odds of infertility (OR=0.42 [0.26-0.69]). Additionally, the observed interaction suggested that the influence of age on the relationship between LS7 and infertility is not consistent across different age groups (P for interaction < 0.001). Among individuals aged 35 or younger, each unit increase in LS7 score was associated with a substantial 18% (OR=0.82 [0.76-0.89]) decrease in the odds of infertility. However, in the older age group (>35), the association was attenuated and non-significant.

Conclusions

Our research suggests a significant inverse association between LS7 scores and infertility. Age demonstrated a varying impact on this relationship, with a more pronounced impact observed among individuals aged 35 or younger.
Multi-scenario renewable energy absorption capacity assessment method based on the attention-enhanced time convolutional network
Authors: Wu Yang , Zhou Han , Zhang Congtong , Liu Shuangquan , Chen Zongyuan
Published: February 2024

As the penetration rate of renewable energy in modern power grids continues to increase, the assessment of renewable energy absorption capacity plays an increasingly important role in the planning and operation of power and energy systems. However, traditional methods for assessing renewable energy absorption capacity rely on complex mathematical modeling, resulting in low assessment efficiency. Assessment in a single scenario determined by the source-load curve is difficult because it fails to reflect the random fluctuation characteristics of the source-load, resulting in inaccurate assessment results. To address and solve the above challenges, this paper proposes a multi-scenario renewable energy absorption capacity assessment method based on an attention-enhanced time convolutional network (ATCN). First, a source-load scene set is generated based on a generative adversarial network (GAN) to accurately characterize the uncertainty on both sides of the source and load. Then, the dependence of historical time series information in multiple scenarios is fully mined using the attention mechanism and temporal convolution network (TCN). Finally, simulation and experimental verification are carried out using a provincial power grid located in southwest China. The results show that the method proposed in this article has higher evaluation accuracy and speed than the traditional model.
Coffee and the risk of osteoarthritis: a two-sample, two-step multivariable Mendelian randomization study
Authors: Zhang Wenzheng , Lei Xuefeng , Tu Yihui , Ma Tong , Wen Tao , Yang Tao , Xue Long , Ji Jiazhong , Xue Huaming
Published: February 2024

Purpose: To investigate the potential causal relationship between coffee consumption and osteoarthritis (OA), and to disentangle whether body mass index (BMI) and Bone mineral density (BMD) mediate this relationship.

Methods: We performed two-sample and two-step Mendelian randomization (MR) analyses utilizing publicly available genome-wide association studies (GWAS) summary statistics to estimate the association between coffee intake and OA risk (including knee OA, hip OA, knee or hip OA, and total OA), as well as the possible mediating effects of BMI and BMD. In addition, data of different coffee types (decaffeinated coffee, instant coffee, ground coffee—including espresso, filter, etc., and other coffee types) were used to explore the effect of coffee type on the risk of OA.

Results: In two-sample MR, coffee intake increased the risk of OA in various sites, with the most significant impact observed in knee osteoarthritis (KOA) (odds ratio [OR] 2.03, 95% confidence interval [CI] 1.57–2.61, p < 0.001). The effect on self-reported OA was minimal (OR 1.03, 95% CI 1.01–1.05, p = 0.006). Further analysis of different types of coffee revealed that only decaffeinated coffee was causally associated with both KOA (OR 4.40, 95% CI 1.71–11.33, p = 0.002) and self-reported OA (OR 1.13, 95% CI 1.02–1.26, p = 0.022). In two-step MR, BMI explained over half of the coffee intake-all OA risk association, while BMD accounted for less than 5% of the mediation effect.

Conclusion: Our study suggests that coffee intake increase the risk of OA, with BMI playing a significant mediating role. Decaffeinated coffee appears to have the greatest impact on OA risk compared to other types of coffee. Therefore, managing BMI and selecting appropriate types of coffee should be included in the health management of individuals who frequently consume coffee.
Mechanisms by which Factor H protects Trypanosoma cruzi from the alternative pathway of complement
Authors: Menon Smrithi S. , Ramirez-Toloza Galia , Wycoff Keith L. , Ehinger Sean , Shaughnessy Jutamas , Ram Sanjay , Ferreira Viviana P.
Published: February 2024

Chagas disease, a chronic disabling disease caused by the protozoan Trypanosoma cruzi, has no standardized treatment or preventative vaccine. The infective trypomastigote form of T. cruzi is highly resistant to killing by the complement immune system. Factor H (FH), a negative regulator of the alternative pathway (AP) of complement on cell surfaces and in blood, contains 20 short consensus repeat domains. The four N-terminal domains of FH inactivate the AP, while the other domains interact with C3b/d and glycan markers on cell surfaces. Various pathogens bind FH to inactivate the AP. T. cruzi uses its trans-sialidase enzyme to transfer host sialic acids to its own surface, which could be one of the approaches it uses to bind FH. Previous studies have shown that FH binds to complement-opsonized T. cruzi and parasite desialylation increases complement-mediated lysis of trypomastigotes. However, the molecular basis of FH binding to T. cruzi remain unknown. Only trypomastigotes, but not epimastigotes (non-infective, complement susceptible) bound FH directly, independent of C3 deposition, in a dose-dependent manner. Domain mapping experiments using 3-5 FH domain fragments showed that domains 5-8 competitively inhibited FH binding to the trypomastigotes by ~35% but did not decrease survival in complement. FH-Fc or mutant FH-Fc fusion proteins (3-11 contiguous FH domains fused to the IgG Fc) also did not kill trypomastigotes. FH-related protein-5, whose domains bear significant sequence identity to all known polyanion-binding FH domains (6-7, 10-14, 19-20), fully inhibited FH binding to trypomastigotes and reduced trypomastigote survival to < 24% in the presence of serum. In conclusion, we have elucidated the role of FH in complement resistance of trypomastigotes.
Forces at play: exploring factors affecting the cancer metastasis
Authors: Riaz Farooq , Zhang Jing , Pan Fan
Published: February 2024

Metastatic disease, a leading and lethal indication of deaths associated with tumors, results from the dissemination of metastatic tumor cells from the site of primary origin to a distant organ. Dispersion of metastatic cells during the development of tumors at distant organs leads to failure to comply with conventional treatments, ultimately instigating abrupt tissue homeostasis and organ failure. Increasing evidence indicates that the tumor microenvironment (TME) is a crucial factor in cancer progression and the process of metastatic tumor development at secondary sites. TME comprises several factors contributing to the initiation and progression of the metastatic cascade. Among these, various cell types in TME, such as mesenchymal stem cells (MSCs), lymphatic endothelial cells (LECs), cancer-associated fibroblasts (CAFs), myeloid-derived suppressor cells (MDSCs), T cells, and tumor-associated macrophages (TAMs), are significant players participating in cancer metastasis. Besides, various other factors, such as extracellular matrix (ECM), gut microbiota, circadian rhythm, and hypoxia, also shape the TME and impact the metastatic cascade. A thorough understanding of the functions of TME components in tumor progression and metastasis is necessary to discover new therapeutic strategies targeting the metastatic tumor cells and TME. Therefore, we reviewed these pivotal TME components and highlighted the background knowledge on how these cell types and disrupted components of TME influence the metastatic cascade and establish the premetastatic niche. This review will help researchers identify these altered components’ molecular patterns and design an optimized, targeted therapy to treat solid tumors and restrict metastatic cascade.
Unraveling lipid and inflammation interplay in cancer, aging and infection for novel theranostic approaches
Authors: Conde-Torres Daniel , Blanco-González Alexandre , Seco-González Alejandro , Suárez-Lestón Fabián , Cabezón Alfonso , Antelo-Riveiro Paula , Piñeiro Ángel , García-Fandiño Rebeca
Published: February 2024

The synergistic relationships between Cancer, Aging, and Infection, here referred to as the CAIn Triangle, are significant determinants in numerous health maladies and mortality rates. The CAIn-related pathologies exhibit close correlations with each other and share two common underlying factors: persistent inflammation and anomalous lipid concentration profiles in the membranes of affected cells. This study provides a comprehensive evaluation of the most pertinent interconnections within the CAIn Triangle, in addition to examining the relationship between chronic inflammation and specific lipidic compositions in cellular membranes. To tackle the CAIn-associated diseases, a suite of complementary strategies aimed at diagnosis, prevention, and treatment is proffered. Our holistic approach is expected to augment the understanding of the fundamental mechanisms underlying these diseases and highlight the potential of shared features to facilitate the development of novel theranostic strategies.
Melatonin: the placental antioxidant and anti-inflammatory
Authors: Joseph Tyana T. , Schuch Viviane , Hossack Daniel J. , Chakraborty Rana , Johnson Erica L.
Published: February 2024

Melatonin (N-acetyl-5-methoxytryptamine) is an indolamine hormone with many physiological and biological roles. Melatonin is an antioxidant, anti-inflammatory, free radical scavenger, circadian rhythm regulator, and sleep hormone. However, its most popular role is the ability to regulate sleep through the circadian rhythm. Interestingly, recent studies have shown that melatonin is an important and essential hormone during pregnancy, specifically in the placenta. This is primarily due to the placenta’s ability to synthesize its own melatonin rather than depending on the pineal gland. During pregnancy, melatonin acts as an antioxidant and anti-inflammatory, which is necessary to ensure a stable environment for both the mother and the fetus. It is an essential antioxidant in the placenta because it reduces oxidative stress by constantly scavenging for free radicals, i.e., maintain the placenta’s integrity. In a healthy pregnancy, the maternal immune system is constantly altered to accommodate the needs of the growing fetus, and melatonin acts as a key anti-inflammatory by regulating immune homeostasis during early and late gestation. This literature review aims to identify and summarize melatonin’s role as a powerful antioxidant and anti-inflammatory that reduces oxidative stress and inflammation to maintain a favorable homeostatic environment in the placenta throughout gestation.
Immune checkpoint inhibitor-induced subacute cutaneous lupus erythematosus: a case report and review of the literature
Authors: Khorasanchi Adam , Korman Abraham M. , Manne Ashish , Meara Alexa
Published: February 2024

Immune checkpoint inhibitor (ICI) use has been associated with numerous autoimmune side effects, known as immune related adverse events (irAEs). Cutaneous irAEs are common and affect up to 50% of patients treated with ICIs. There have been an increasing number of cases reported in the literature regarding ICI-induced subacute cutaneous lupus erythematosus (SCLE). ICI-induced SCLE is important to recognize as it can result in a delayed and/or prolonged skin reaction despite treatment discontinuation. We describe a patient with gastro-esophageal adenocarcinoma who developed SCLE following one cycle of nivolumab treatment. A 75-year-old man presented to our clinic with a new photo-distributed rash composed of oval scaly pink papules and plaques involving his chest and arms. Despite treatment with topical corticosteroids, he presented to the emergency department 1 week later with worsening rash. Skin biopsy showed vacuolar interface pattern, along with superficial perivascular lymphocytic infiltrate, consistent with a drug eruption. The clinicopathological presentation was consistent with ICI-induced SCLE. Nivolumab treatment was discontinued due to the severity of the rash. The rash remitted with systemic corticosteroids, high potency topical steroids, and hydroxychloroquine. Unfortunately, the patient developed intraperitoneal metastatic disease, and was enrolled in hospice care. In this paper, we highlight the importance of early identification and treatment of this irAE. A review of the literature, including a discussion on the management of ICI-induced SCLE is also provided.
Bioactive polyketides and meroterpenoids from the mangrove-derived fungus Talaromyces flavus TGGP35
Authors: Cai Jin , Zhou Xueming , Wang Bin , Zhang Xuelong , Luo Mengyao , Huang Longtao , Wang Ruoxi , Chen Yonghao , Li Xiaoyang , Luo Youping , Chen Guangying , Cao Fei , Huang Guolei , Zheng Caijuan
Published: February 2024

Six new polyketides, which includes three new lactones (talarotones A–C) (1–3), one new polyketide (talarotide A) (4), two new polyenes (talaroyenes A, B) (5, 6), together with one new meroterpenoid (talaropenoid A) (7) and 13 known compounds (8–20) were isolated from the mangrove-derived fungus Talaromyces flavus TGGP35. The structure and configuration of the compounds 1–7 were elucidated from the data obtained from HR-ESI-MS, IR, 1D/2D NMR spectroscopy, Mo2 (OAc)4-induced electronic circular dichroism (ECD), CD spectroscopy, and modified Mosher's method. Compounds 5 and 20 displayed antioxidant activity with IC50 values of 0.40 and 1.36 mM, respectively. Compounds 3, 6, 11, 16, and 17 displayed cytotoxic activity against human cancer cells Hela, A549, and had IC50 values ranging from 28.89 to 62.23 μM. Compounds 7, 10–12, and 14–18 exhibited moderate or potent anti-insect activity against newly hatched larvae of Helicoverpa armigera Hubner, with IC50 values in the range 50–200 μg/mL. Compound 18 showed antibacterial activity against Ralstonia solanacearum with the MIC value of 50 μg/mL.
Are the minimally invasive techniques the new gold standard in thymus surgery for myasthenia gravis? Experience of a reference single-site in VATS thymectomy
Authors: Trujillo Reyes Juan Carlos , Martinez Tellez Elisabeth , Belda Sanchis Josep , Planas Canovas Georgina , Libreros Niño Alejandra , Guarino Mauro , Hernández Ferrandez Jorge , Moral Duarte Antonio
Published: February 2024

The thymus is the primary lymphoid organ responsible for the maturation and proliferation of T lymphocytes. During the first years of our lives, the activation and inactivation of T lymphocytes occur within the thymus, facilitating the correct maturation of central immunity. Alterations in the positive and negative selection of T lymphocytes have been studied as the possible origins of autoimmune diseases, with Myasthenia Gravis (MG) being the most representative example. Structural alterations in the thymus appear to be involved in the initial autoimmune response observed in MG, leading to the consideration of thymectomy as part of the treatment for the disease. However, the role of thymectomy in MG has been a subject of controversy for many years. Several publications raised doubts about the lack of evidence justifying thymectomy’s role in MG until 2016 when a randomized study comparing thymectomy via sternotomy plus prednisone versus prednisone alone was published in the New England Journal of Medicine (NEJM). The results clearly favored the group of patients who underwent surgery, showing improvements in symptoms, reduced corticosteroid requirements, and fewer recurrences over 3 years of follow-up. In recent years, the emergence of less invasive surgical techniques has made video-assisted or robotic-assisted thoracoscopic (VATS/RATS) thymectomy more common, replacing the traditional sternotomy approach. Despite the increasing use of VATS, it has not been validated as a technique with lower morbidity compared to sternotomy in the treatment of MG. The results of the 2016 trial highlighted the benefits of thymectomy, but all the patients underwent surgery via sternotomy. Our hypothesis is that VATS thymectomy is a technique with lower morbidity, reduced postoperative pain, and shorter postoperative hospital stays than sternotomy. Additionally, VATS offers better clinical improvement in patients with MG. The primary objective of this study is to validate the VATS technique as the preferred approach for thymectomy. Furthermore, we aim to analyze the impact of VATS thymectomy on symptoms and corticosteroid dosage in patients with MG, identifying factors that may predict a better response to surgery.
A comprehensive dataset for home appliance control using ERP-based BCIs with the application of inter-subject transfer learning
Authors: Lee Jongmin , Kim Minju , Heo Dojin , Kim Jongsu , Kim Min-Ki , Lee Taejun , Park Jongwoo , Kim HyunYoung , Hwang Minho , Kim Laehyun , Kim Sung-Phil
Published: February 2024

Brain-computer interfaces (BCIs) have a potential to revolutionize human-computer interaction by enabling direct links between the brain and computer systems. Recent studies are increasingly focusing on practical applications of BCIs—e.g., home appliance control just by thoughts. One of the non-invasive BCIs using electroencephalography (EEG) capitalizes on event-related potentials (ERPs) in response to target stimuli and have shown promise in controlling home appliance. In this paper, we present a comprehensive dataset of online ERP-based BCIs for controlling various home appliances in diverse stimulus presentation environments. We collected online BCI data from a total of 84 subjects among whom 60 subjects controlled three types of appliances (TV: 30, door lock: 15, and electric light: 15) with 4 functions per appliance, 14 subjects controlled a Bluetooth speaker with 6 functions via an LCD monitor, and 10 subjects controlled air conditioner with 4 functions via augmented reality (AR). Using the dataset, we aimed to address the issue of inter-subject variability in ERPs by employing the transfer learning in two different approaches. The first approach, “within-paradigm transfer learning,” aimed to generalize the model within the same paradigm of stimulus presentation. The second approach, “cross-paradigm transfer learning,” involved extending the model from a 4-class LCD environment to different paradigms. The results demonstrated that transfer learning can effectively enhance the generalizability of BCIs based on ERP across different subjects and environments.
Optimization of tomato (Solanum lycopersicum L.) juice fermentation process and analysis of its metabolites during fermentation
Authors: Zhao Lei , Maimaitiyiming Ruxianguli , Hong Jingyang , Wang Liang , Mu Ying , Liu Bingze , Zhang Huimin , Chen Keping , Aihaiti Aihemaitijiang
Published: February 2024

Tomato (Solanum lycopersicum L.) is a nutritious fruit and vegetable. Fermentation can be used to enhance their nutritional value. In this study, the tomato juice was co-fermented with multistrains, optimized by uniform experimental design and response surface methodology. Superoxide dismutase activity reached 496.67 U/g and lycopene content reached 77.12μg/g when P. pentosaceus (53.79%), L. casei (13.17%), L. plantarum (19.87%), L. fermentum (13.17%). To gain insight into the dynamics of metabolites during the tomato fermentation juice process multivariate statistical analysis was performed using the UHPLC-QE-MS/MS method. The main metabolites are peptides, amino acids carbohydrates, organic acids, and phospholipids. Carbohydrates were fully retained at the end of fermentation.The content of galactitol increased from the initial 5.389 to 6.607 while the content of cytarabine decreased by 29% and uridine by 44%. Meanwhile, phospholipids (PS, PE, PC, PG, PI) were all retained by more than 70%. Terpenoids (16-deacetylgairin, (+)-Royleanone, artemisinin) were increased to varying degrees, which gives them good nutritional value and biological activity. Organic acids (malic and citric) were reduced and lactic acid content was increased, changing its original flavor and making it more palatable to the general population. The research results have demonstrated the benefits of lactic acid bacteria fermentation on tomato juice, providing a theoretical basis and reference for the fermentation metabolism process of tomato juice.
The role of microbiomes in gastrointestinal cancers: new insights
Authors: Yarahmadi Aref , Afkhami Hamed
Published: February 2024

Gastrointestinal (GI) cancers constitute more than 33% of new cancer cases worldwide and pose a considerable burden on public health. There exists a growing body of evidence that has systematically recorded an upward trajectory in GI malignancies within the last 5 to 10 years, thus presenting a formidable menace to the health of the human population. The perturbations in GI microbiota may have a noteworthy influence on the advancement of GI cancers; however, the precise mechanisms behind this association are still not comprehensively understood. Some bacteria have been observed to support cancer development, while others seem to provide a safeguard against it. Recent studies have indicated that alterations in the composition and abundance of microbiomes could be associated with the progression of various GI cancers, such as colorectal, gastric, hepatic, and esophageal cancers. Within this comprehensive analysis, we examine the significance of microbiomes, particularly those located in the intestines, in GI cancers. Furthermore, we explore the impact of microbiomes on various treatment modalities for GI cancer, including chemotherapy, immunotherapy, and radiotherapy. Additionally, we delve into the intricate mechanisms through which intestinal microbes influence the efficacy of GI cancer treatments.