bluuebunny/crossref_metadata_2025 huggingface dataset:
Women Agricultural Engagement: Myth or Panacea for Income Empowerment of Women in Africa South of the Sahara
Authors: Oteng Clement , Gamette Pius
Published: September 2024

Income disparity between females and males in the Global South continues to grow, especially in Africa South of the Sahara (SSA). In this current study, we have analyzed the effect of engagement in agriculture by women on income disparity in SSA. Data between 1991 and 2018 from two main sources were used for the analyses of the study. The sources of the data were the Global Development Index and Standard World Income Inequality Database databases. To analyze the results, we employed the two‐stage least squares and pooled ordinary least squares estimation methods. From the analyses of the results, we found that women’s engagement in agriculture (WOMENAP) reduced inequalities in income distribution in Africa. WOMENAP lowered the disparity in Southern and Western Africa but worsened it in Central and Eastern Africa. The study concluded that women’s involvement in agriculture reduced income inequality (InE). Specifically, women who work in agriculture are able to contribute to reducing InE in southern and western parts of Africa. However, WOMANAP exacerbated InE in the eastern and central parts of Africa. The study, therefore, recommended maintaining gender balance in agriculture to close the existing economic gap.
Phenotype Correlations With Pathogenic DNA Variants in the MUTYH Gene: A Review of Over 2000 Cases
Authors: Thet Monica , Plazzer John-Paul , Capella Gabriel , Latchford Andrew , Nadeau Emily A. W. , Greenblatt Marc S. , Macrae Finlay
Published: September 2024

MUTYH‐associated polyposis (MAP) is an autosomal recessive disorder where the inheritance of constitutional biallelic pathogenic MUTYH variants predisposes a person to the development of adenomas and colorectal cancer (CRC). It is also associated with extracolonic and extraintestinal manifestations that may overlap with the phenotype of familial adenomatous polyposis (FAP). Currently, there are discrepancies in the literature regarding whether certain phenotypes are truly associated with MAP. This narrative review is aimed at exploring the phenotypic spectrum of MAP to better characterize the MAP phenotype. Literature search was conducted to identify articles reporting on MAP‐specific phenotypes. Clinical data from 2109 MAP patients identified from the literature showed that 1123 patients (53.2%) had CRC. Some patients with CRC had no associated adenomas, suggesting that adenomas are not an obligatory component of MAP. Carriers of the two missense founder variants, and possibly truncating variants, had an increased cancer risk when compared to those who carry other pathogenic variants. It has been suggested that somatic G:C > T:A transversions are a mutational signature of MAP and could be used as a biomarker in screening and identifying patients with atypical MAP, or in associating certain phenotypes with MAP. The extracolonic and extraintestinal manifestations that have been associated with MAP include duodenal adenomas, duodenal cancer, fundic gland polyps, gastric cancer, ovarian cancer, bladder cancer, and skin cancer. The association of breast cancer and endometrial cancer with MAP remains disputed. Desmoid tumors and congenital hypertrophy of the retinal pigment epithelium (CHRPEs) are rarely reported in MAP but have long been seen in FAP patients and thus could act as a distinguishing feature between the two. This collection of MAP phenotypes will assist in the assessment of pathogenic MUTYH variants using the American College of Medical Genetics and the Association for Molecular Pathology (ACMG/AMP) Variant Interpretation Guidelines and ultimately improve patient care.
Modal Property‐Based Data Anomaly Detection Method for Autonomous Stay‐Cable Monitoring System in Cable‐Stayed Bridges
Authors: Jeong Seunghoo , Jin Seung-Seop , Sim Sung-Han
Published: September 2024

This study presents a novel framework for data anomaly detection in stay‐cables, aimed at establishing an autonomous monitoring system in cable‐stayed bridges. Based on the fact that peaks in the power spectra of cable accelerations appear periodically at constant intervals, we classified the anomalous data into two categories in terms of the data quality and behavioral aspects. The framework provides two thresholds derived from the modal property of stay‐cables to identify each anomaly type. To validate the performance of the proposed method, we collected long‐term monitoring data from stay‐cables in a cable‐stayed bridge currently in operation in South Korea. Then, the peak information was extracted by adopting an automatic peak‐picking technique. We applied the proposed method to establish thresholds that determine the presence of anomalous data. This study validated that the proposed method can determine anomalous types when new data are used as input.
Humans Mindlessly Treat AI Virtual Agents as Social Beings, but This Tendency Diminishes Among the Young: Evidence From a Cyberball Experiment
Authors: Zhou Jianan , Porat Talya , van Zalk Nejra
Published: September 2024

The “social being” perspective has largely influenced the design and research of AI virtual agents. Do humans really treat these agents as social beings? To test this, we conducted a 2 between (Cyberball condition: exclusion vs. fair play) × 2 within (coplayer type: AGENT vs. HUMAN) online experiment employing the Cyberball paradigm; we investigated how participants (N = 244) responded when they observed an AI virtual agent being ostracised or treated fairly by another human in Cyberball, and we compared our results with those from human–human Cyberball research. We found that participants mindlessly applied the social norm of inclusion, compensating the ostracised agent by tossing the ball to them more frequently, just as people would to an ostracised human. This finding suggests that individuals tend to mindlessly treat AI virtual agents as social beings, supporting the media equation theory; however, age (no other user characteristics) influenced this tendency, with younger participants less likely to mindlessly apply the inclusion norm. We also found that participants showed increased sympathy towards the ostracised agent, but they did not devalue the human player for their ostracising behaviour; this indicates that participants did not mindfully perceive AI virtual agents as comparable to humans. Furthermore, we uncovered two other exploratory findings: the association between frequency of agent usage and sympathy, and the carryover effect of positive usage experience. Our study advances the theoretical understanding of the human side of human–agent interaction. Practically, it provides implications for the design of AI virtual agents, including the consideration of social norms, caution in human‐like design, and age‐specific targeting.
Study on Single Event Upset and Mitigation Technique in JLTFET‐Based 6T SRAM Cell
Authors: K Aishwarya , B Lakshmi
Published: September 2024

The effect of single event transient (SET) on 6T SRAM cell employing a 20 nm silicon‐based junctionless tunneling field effect transistor (JLTFET) is explored for the first time. JLTFET‐based SRAM circuit is designed using the look up table‐based Verilog A code obtained from TCAD values of the device. After verifying SRAM circuit for its functionality, the stability parameters, read static noise margin (RSNM), write static noise margin (WSNM), read/write delay, and power consumption are evaluated. It is observed that the circuit has a good stability of noise margin and lesser delay. The radiation study is carried out using a transient current source striking at one of the output nodes. This causes single event upset (SEU) which changes the data stored in the memory cell giving rise to soft error (SER). SER is recovered by the radiation hardening by design (RHBD) technique with an additional RC network between two cross coupled inverters. The performance metrics, read/write delay, and the power consumption before, during, and after the radiation strike are analyzed. It is observed that SER gets totally eliminated with less recovery time at the expense of a slight increase in power and delay.
Research Status and Trends in Periodontal Ligament Stem Cells: A Bibliometric Analysis over the Past Two Decades
Authors: Li Zhengyang , Li Jinyi , Dai Shanshan , Liu Ruirui , Guo Qingyu , Liu Fei
Published: September 2024

Objective. Currently, the summaries of research on periodontal ligament stem cells (PDLSCs) are mainly reviews, and the systematic evaluation of all relevant studies is lacking. The aim of our study was to reveal the research status and developmental trends of PDLSCs using bibliometric analyses. Methods. Publications on PDLSC from 2004 to 2023 in the PubMed database were searched and then screened according to certain inclusion and exclusion criteria. Two researchers browsed the included papers and recorded information such as the research type and research model. The VOSviewer software was used to analyze the distribution of authors, journals, and institutions. The contents and directions of PDLSC research were summarized by analyzing high‐frequency keywords. The CiteSpace software was used to monitor burst words, determine hot factors, and indicate developmental trends. Results. During the past two decades, the number of studies on PDLSCs increased. China published the most related papers. The primary type of article was basic research. Among core journals, the Journal of Periodontal Research had the highest number of publications. The Fourth Military Medical University (China) was leading in the number of articles on PDLSCs. Research topics mainly included mechanism of periodontal diseases, tissue engineering and regeneration, biological characteristics of PDLSCs, and comparison with other stem cells. Infectious inflammation and mechanical stimulation were important pathological conditions and research topics. Conclusion. The research of PDLSCs is still in a rapid development stage. Our study provides new insights into the current research status and future trend in this field.
Supplementary Figures from Integration of Clinical Trial Spatial Multiomics Analysis and Virtual Clinical Trials Enables Immunotherapy Response Prediction and Biomarker Discovery
Authors: Zhang Shuming , Deshpande Atul , Verma Babita K. , Wang Hanwen , Mi Haoyang , Yuan Long , Ho Won Jin , Jaffee Elizabeth M. , Zhu Qingfeng , Anders Robert A. , Yarchoan Mark , Kagohara Luciane T. , Fertig Elana J. , Popel Aleksander S.
Published: September 2024

Supplemental Figure with Caption
Supplementary Equations from Integration of Clinical Trial Spatial Multiomics Analysis and Virtual Clinical Trials Enables Immunotherapy Response Prediction and Biomarker Discovery
Authors: Zhang Shuming , Deshpande Atul , Verma Babita K. , Wang Hanwen , Mi Haoyang , Yuan Long , Ho Won Jin , Jaffee Elizabeth M. , Zhu Qingfeng , Anders Robert A. , Yarchoan Mark , Kagohara Luciane T. , Fertig Elana J. , Popel Aleksander S.
Published: September 2024

Supplemental mathematical equations of the spQSP model
Supplementary Data Table 1 from Integration of Clinical Trial Spatial Multiomics Analysis and Virtual Clinical Trials Enables Immunotherapy Response Prediction and Biomarker Discovery
Authors: Zhang Shuming , Deshpande Atul , Verma Babita K. , Wang Hanwen , Mi Haoyang , Yuan Long , Ho Won Jin , Jaffee Elizabeth M. , Zhu Qingfeng , Anders Robert A. , Yarchoan Mark , Kagohara Luciane T. , Fertig Elana J. , Popel Aleksander S.
Published: September 2024

SpaceMarker result for all virtual patients
Supplementary Data from E-Cadherin Induces Serine Synthesis to Support Progression and Metastasis of Breast Cancer
Authors: Lee Geonhui , Wong Claudia , Cho Anna , West Junior J. , Crawford Ashleigh J. , Russo Gabriella C. , Si Bishwa R. , Kim Jungwoo , Hoffner Lauren , Jang Cholsoon , Jung Moonjung , Leone Robert D. , Konstantopoulos Konstantinos , Ewald Andrew J. , Wirtz Denis , Jeong Sangmoo
Published: September 2024

Supplementary data
Supplementary Table 3 from Generation, Transcriptomic States, and Clinical Relevance of CX3CR1+ CD8 T Cells in Melanoma
Authors: Ishigaki Hirohito , Yamauchi Takayoshi , Long Mark D. , Hoki Toshifumi , Yamamoto Yuta , Oba Takaaki , Ito Fumito
Published: September 2024

Supplementary Table 3
Supplementary Figure 3 from Generation, Transcriptomic States, and Clinical Relevance of CX3CR1+ CD8 T Cells in Melanoma
Authors: Ishigaki Hirohito , Yamauchi Takayoshi , Long Mark D. , Hoki Toshifumi , Yamamoto Yuta , Oba Takaaki , Ito Fumito
Published: September 2024

Gating strategy to analyze the adoptively transferred Pmel-1 T cells with CD90.1 expression.
Supplementary Figure 2 from Generation, Transcriptomic States, and Clinical Relevance of CX3CR1+ CD8 T Cells in Melanoma
Authors: Ishigaki Hirohito , Yamauchi Takayoshi , Long Mark D. , Hoki Toshifumi , Yamamoto Yuta , Oba Takaaki , Ito Fumito
Published: September 2024

Gating strategy to analyze CX3CR1 expression on CD8+ T cells in human melanoma TILs.
Supplementary Table 4 from SREBP-Dependent Regulation of Lipid Homeostasis Is Required for Progression and Growth of Pancreatic Ductal Adenocarcinoma
Authors: Ishida Chiaki T. , Myers Stephanie L. , Kubota Casie S. , Shao Wei , McGuire Meredith R. , Liu Chune , Ewachiw Theodore E. , Mukhopadhyay Debaditya , Ke Suqi , Wang Hao , Rasheed Zeshaan A. , Anders Robert A. , Espenshade Peter J.
Published: September 2024

Table S4. Pa03c cell microarray gene expression data
Supplementary Validation Data S2 from mTORC1-Driven Protein Translation Correlates with Clinical Benefit of Capivasertib within a Genetically Preselected Cohort of PIK3CA-Altered Tumors
Authors: Sobsey Constance A. , Froehlich Bjoern C. , Mitsa Georgia , Ibrahim Sahar , Popp Robert , Zahedi Rene P. , de Bruin Elza C. , Borchers Christoph H. , Batist Gerald
Published: September 2024

Quality Assessment of the Global Proteomics Data
Supplementary Figure 2 from SREBP-Dependent Regulation of Lipid Homeostasis Is Required for Progression and Growth of Pancreatic Ductal Adenocarcinoma
Authors: Ishida Chiaki T. , Myers Stephanie L. , Kubota Casie S. , Shao Wei , McGuire Meredith R. , Liu Chune , Ewachiw Theodore E. , Mukhopadhyay Debaditya , Ke Suqi , Wang Hao , Rasheed Zeshaan A. , Anders Robert A. , Espenshade Peter J.
Published: September 2024

FIGURE S2 – Mouse genotyping methods and survival study data
Kidney-Limited Microangiopathy Associated with Methionine Synthase (Cobalamin G) Deficiency in a Pediatric Patient: Case Report and Review of the Literature
Authors: Zuckerman Jonathan E. , Srivastava Rachana
Published: September 2024

Thrombotic microangiopathy (TMA) is a recognized sequela of inborn errors of metabolism impacting vitamin B12 (cobalamin) synthesis. Methylmalonic aciduria and homocystinuria, cobalamin deficiency type C is a well-known etiology for TMA. TMA has only rarely previously been reported in methionine synthase (cobalamin G) deficiency. Furthermore, results of only 7 kidney biopsies have previously been reported in this clinical setting. Here, we report a case of kidney- and glomerular-limited chronic active microangiopathy demonstrated on kidney biopsy in a patient with biochemically confirmed cobalamin G deficiency. A literature review of all prior reported cases is also presented and demonstrates hypertension, proteinuria, and hematuria to be common presenting symptoms. Age on onset ranged from 7 months to 14 years. Kidney-limited phenotype was less common and occurred only in older children. Acute kidney injury was more common in younger patients. Therapy with hydroxocobalamin and angiotensin-converting enzyme inhibitors resulted in variable clinical responses.
Non-Coding RNA Networks in Pulmonary Arterial Hypertension
Authors: Chen Bing , Xia Yu , Jiang Yanjiao , Sun Zengxian , Zhang Yanyan , Liu Yun
Published: September 2024

Background: Pulmonary artery hypertension (PAH) is a severe cardiovascular disease marked by a persistent increase in pulmonary artery resistance and pressure, leading to right ventricular strain, hypertrophy, and eventually right heart failure and death. Despite numerous available targeted therapies, the clinical needs for treating PAH remain unmet. Current treatments primarily aim to dilate pulmonary vessels rather than reverse pulmonary vascular remodeling, failing to offer a fundamental solution for PAH. Therefore, developing new therapies for this condition is urgently required. Summary: Recent research has highlighted the crucial role of non-coding RNAs (ncRNAs) in the occurrence and development of PAH. NcRNAs, such as long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), microRNAs (miRNAs), and PIWI-interacting RNAs (piRNAs), are a class of transcripts that do not translate proteins but affect various diseases at different levels, including chromatin modification, transcription regulation, post-translational processes. Key Message: The current study delves into recent advancements in understanding how lncRNAs, circRNAs, miRNAs, and piRNAs contribute to the pathogenesis of PAH. This review addresses the existing research challenges and explores the potential of ncRNAs as both biomarkers and therapeutic targets, suggesting that ncRNAs may serve as valuable indicators and treatment options for the disease.
Experience in the Treatment of Male Prolactinomas: A Single-Center, 10-Year Retrospective Study
Authors: Ke Xiaoan , Chen Xiaoxue , Wang Linjie , Duan Lian , Yang Hongbo , Yao Yong , Deng Kan , Pan Hui , Gong Fengying , Zhu Huijuan
Published: September 2024

Introduction: Male prolactinomas are uncommon and typically macroadenomas with difficult treatment and management. The purpose of this study was to summarize the treatment and management experiences of 254 male prolactinoma patients at a single center. Methods: This was a 10-year retrospective study conducted at a single center. A total of 254 male prolactinoma patients were included. Clinical data for all subjects were collected using an electronic medical record system. Results: A total of 254 male patients with prolactinoma were studied. Their median age at onset was 28.8 years, and median disease duration was 28.5 months. The median PRL levels were 582.0 ng/mL at diagnosis. Their median maximum tumor diameter was 23.0 mm, with macroadenoma accounting for the majority (76.7%). After treatment, the biochemical remission rate with monotherapy was 36.6%, but significantly increased to 60.6% with multidisciplinary treatment (p < 0.001). Knosp 0–2 patients had significantly higher rates of biochemical remission compared to Knosp 3–4 (all p < 0.05). In addition, the maximum diameter of adenoma (B = −0.110, p = 0.008) and cavernous sinus invasion (B = −1.741, p = 0.023) were negatively correlated with postoperative biochemical remission. The maximum diameter of the adenoma (B = − 0.131, p < 0.001) was a negative correlation factor, while treatment duration (B = 0.034, p = 0.002) was a positive correlation factor for biochemical response to medication. Conclusion: Male prolactinoma has a low biochemical remission rate when treated alone, but multitherapy can improve it even more. Surgery may also be considered for male prolactinoma with a micro, and noninvasive tumor after a thorough evaluation.
Liberal Intergovernmentalism Under Revision: The EEAS and the Creation of a Supra-State Diplomatic Body
Authors: Lamoso González Paula
Published: September 2024

Why do Member States agree to create supra-state institutions? Do institutional frameworks affect outcomes? This study employs theory-testing process tracing to contribute to liberal intergovernmentalism by examining the configuration process of the European External Action Service, negotiated within two innovative institutional settings: the Convention and the Quadrilogue. The study concludes that liberal intergovernmentalism needs to be nuanced, as institutional settings are crucial in building supra-state institutions by shaping actors’ behaviour through available choices and conclusions. The bargaining was supra-state rather than intergovernmental. Preference formation was domestic but not liberal, as no interest group, other than the diplomatic corps, was involved. The European External Action Service was agreed upon as a package deal based on benefits to Member States and EU institutional actors, along with control mechanisms. Evidence comes from sixty in-depth elite interviews with EU officials and member state representatives directly involved in the negotiations.
Association Between Sleep Hygiene Parameters and Sleep Habits in 5- to 10-Year-Old School-Age Children
Authors: Dogrul Halil , Doganer Yusuf Cetin , Aydogan Umit , Bayrak Rumeysa Nur
Published: September 2024

Insufficient sleep can lead to problems. We examined the sociodemographic characteristics, sleep habits, and association between sleep problems. Parents were requested to fill out a survey and Children’s Sleep Habits Questionnaire (CSHQ). The mean age of 1226 students was 8.42 (5.0-10.0) years. A total of 50.7% were male students. In addition, 69.1% showed signs of sleep problems in the CSHQ. In multivariate logistic regression analysis, bed-sharing, owning cell phone, attending early education group, not using toilet before bedtime, television watching duration, being an only child, not doing physical activity, watching TV before bed on weekends, caffeinated beverage consumption, not reading a book before sleep, waking up at night, sleeping in lighted rooms, maternal education level, having 1 sibling, and not having tablet variables were statistically significant in causing sleep problems. Poor sleep habits and sleep hygiene problems are common in school-age children. Healthy sleep habits are essential to get adequate and quality sleep.
Socio-Spatial Differentiation of Chinese Shadow Education Activities During its Peak Period: A Case Study of Dalian Urban Area
Authors: Tianbao Liu , Zhenbo Pan
Published: September 2024

Based on the survey data of shadow education activities of junior middle school students in Dalian, China in 2020, this paper analyzes the socio-spatial differentiation of participation, activity spatial distribution and travel distance. It’s found that: (1) The participation rate reaches 74.17%. In general, the higher socioeconomic status strata have more advantages both in participation rate and registered subjects’ number. Spatially, though the suburban area has the lowest participation rate, the largest registered subjects’ number per student is there. (2) Spatial agglomeration of shadow education activities is obvious, mainly gathering in commercial centers, around schools and residential areas and forming a relatively dispersed multi-core structure. The activities of the middle socioeconomic status strata are most widely distributed. (3) The average travel distance of shadow education is almost twice that of travel to school. The average distance goes up with the rise of social strata with the only exception of the highest stratum because of their enjoying of superior locations. Students in the suburban area have the longest travel distance due to their large number of travels to the urban core area. Also, students registered for more than one shadow education subjects’ number have a much higher proportion of long-distance travel.
How critical junctures shape secessionist movement cohesion: Strategies, framing processes, and interorganizational relations before and after the 2017 referendum in Catalonia
Authors: Gunzelmann Hans Jonas
Published: September 2024

What drives the cohesion of secessionist movements? Previous research emphasized the role of internal and external factors but produced mixed results regarding their effects. This article advances scholarship on this question by examining the role of critical junctures as periods of heightened contingency that can shift movements towards fragmentation or cohesion. It focuses on independence referendums and how states respond to them as important critical junctures, and on how they shape interorganizational relations as a key dimension of movement cohesion. Empirically, it explores the effects of the 2017 referendum in Catalonia using a mixed-methods research design that combines qualitative inquiry with network analyses of protest event data. The network analyses showed that the movement was notably less cohesive in the protest arena after the referendum than during the referendum campaign. Qualitative materials were employed to inductively identify strategy framing processes as key mechanisms to explain this development. Frame alignment around the referendum as a shared goal led to more cohesion during the campaign. After the event, a frame dispute over the meaning of the referendum led to diverging strategies and fragmented the movement, as state repression limited the movement’s room for maneuver. The findings suggest that research on secessionist movement cohesion should pay more attention to critical junctures and how secessionists make sense of them.
Short Form of Mental Health Literacy Questionnaire for Adults: Psychometric Properties of Serbian Version
Authors: Kovacevic Lepojevic Marina , Radanovic Ana , Trajkovic Marija , Mijatovic Luka , Micic Isidora
Published: September 2024

Mental health literacy (MHL) has been widely explored by researchers who focus on youth mental health. However, there is little data related to the validity and reliability of the tools for the assessment of MHL constructs. The present study aimed to adapt the short version of Mental Health Literacy Questionnaire for young adults in Serbian sample and examine its psychometric properties. Translation and adaptation of items were performed using the following procedures: item are translated from English or Serbian by a bilingual translator and using a think-aloud procedure, back-translation, semantic comparison of the translation, and analysis of the translated version by the original version of the manuscript. The sample consisted of 344 participants aged 17 to 25 years, which is in accordance with the recommended number of participants needed for quantitative instrument validation studies. Confirmatory factor, internal consistency, and external validity analyses were performed. The results supported the validity of a shorter version of the questionnaire (MHLq-SVa), composed of 16 items that fit with four previously defined MHL dimensions (knowledge, beliefs, help-seeking intentions, and self-help strategies). Internal consistency, between-factor correlations, and correlations with other relevant mental health constructs further supported the adequacy of the instrument’s psychometric properties. We recommend the MHLq-SVa as valid and reliable measure for assessing MHL in young adults and encourage further exploration at more diverse and representative samples.
Age-Friendly Health Systems Integration into Rural Primary Care Clinics: A Journey of One Geriatric Workforce Enhancement Program
Authors: Tobey-Moore Leah , Scalzo Katherine , Massey Stacie , McAtee Robin
Published: September 2024

This study explores the implementation of the Age-Friendly Health Systems (AFHS) 4Ms Framework into primary care clinics in rural Arkansas, facilitated by the AGEC and funded by The Health Resources and Services Administration’s Geriatric Workforce Enhancement Program (GWEP) grant. Implementation success is evaluated by monitoring merit-based incentive payment system (MIPS) measures and other variables, providing insight into the effectiveness of integrating AFHS and enhancing older adult care. AGEC employed implementation strategies (train-the-trainer, audit and feedback, and clinical reminders using Electronic Medical Record (EMR)), the i-PARIHS implementation framework, and the RE-AIM evaluation framework to facilitate integration of the AFHS 4Ms Framework into partnered rural federally qualified healthcare clinics (FQHC). AGEC aimed to equip the healthcare workforce through comprehensive training sessions and resource provision. Additionally, the EMR system modifications guided clinicians in aligning care with the AFHS 4Ms Framework. This multifaceted approach ensured a systematic and tailored implementation, enhancing the capacity of rural FQHCs in Arkansas to deliver Age-Friendly care. Improvements were observed in MIPS outcome measures, including increased completion of fall and depression screens, Annual Wellness Visits (AWV) and Advance Care Plans (ACP). These changes reflect a proactive impact on comprehensive care delivery for older adults. Since adopting the AFHS 4Ms Framework, these rural Arkansas FQHC clinics have significantly enhanced their older adult care, earning recognition as AFHS Clinics by the Institute for Health Improvement (IHI). Primary care practices nationwide can implement similar evidence-based approaches to improve care for the expanding older adult population in the U.S.
John’s Immersions: Ritual Purification, but from What?
Authors: Kazen Thomas
Published: September 2024

From what would John’s immersions purify? Considering texts from the Synoptics, Josephus, and 1QS on purification, sin, and forgiveness, various options are outlined and disentangled with the help of conceptual metaphor theory, especially conceptual blending, and the theory of ritual form. Although John’s immersion was a ritual innovation, broadening ritual purification to include the removal of offensive acts and a change of behaviour by a physical water ritual, a conceptual blending analysis speaks strongly against immersion as a substitute for sacrifice and questions any confusion in relation to the priestly purity system. The theory of ritual form suggests an infrequent and high-arousal Special Agent ritual. Features reminiscent of pre-Hasmonean practices (river and ‘wilderness’ rather than miqveh), gave John’s rite a sense of genuineness and divine agency, making it attractive and emotionally satisfying. The eschatological setting of general purification in view of a divine encounter further contributed to the ritual’s success.
Multi-fault diagnosis of rolling mill main drive system based on UIO–DBO–SVM
Authors: Zhang Ruicheng , He Hao , Liang Weizheng
Published: September 2024

In this paper, the fault diagnosis problem of the main drive system of rolling mill with multiple faults occurring at the same time is studied. Considering the internal equivalent current loop and nonlinear friction damping, the nonlinear mathematical model of the main drive system of rolling mill is established. A new fault diagnosis solution based on model residual and data classifier is proposed to solve the problem of complex fault in this system. In the first stage, the unknown input observer (UIO) is designed for system fault detection. The observer design of the system using the [Formula: see text] index will ensure the robustness of fault diagnosis. Lyapunov theory and linear matrix inequality are introduced to prove the convergence of the proposed observer. In the second stage, each set of coupled residual signals generated by the observer is treated as a separate subsequence and modeled and classified directly using a knowledge support vector machine (SVM). Aiming at the nonlinear separability and complexity of residual data set, dung beetle optimization (DBO) algorithm was used to optimize SVM model parameters. The numerical simulation results of 2030-mm cold rolling mill show that the UIO method can rapidly track the system at a speed of 0.2 seconds, the error of motor angular velocity estimation is 0.33% less than that of the extended state observer, and it is more robust. At the same time, the proposed DBO-SVM is compared with SVM, particle swarm optimization (PSO) algorithm-SVM, and jumping spider optimization algorithm (JSOA)-SVM, and the classification accuracy of the proposed DBO-SVM is 99.86%. This scheme not only provides a solution for the detection and classification of complex faults in the main drive of rolling mill, but also provides a new idea for the fault diagnosis of other complex mechanical equipment.
Quantifying the Influence of Tank Car Position and Train Configuration on the Risk of Rail Transport of Class 3 Flammable Liquids
Authors: Kang Di , Zhao Jiaxi , Dick C. Tyler , Liu Xiang , Lin Chen-Yu , Bian Zheyong , Kirkpatrick Steven W.
Published: September 2024

As the amount of high-hazardous materials (hazmat) being shipped in high-hazard flammable unit trains (HHFUT) increases, mitigating the risks associated with railway transportation of hazmat remains an industry priority. Compared with HHFUT configurations, the placement of hazmat railcars in high-hazard flammable trains (HHFT) and the number of classification yards they traverse can affect the risk of derailment and subsequent hazmat release for HHFTs. This paper evaluates hazmat release risks associated with the transportation of U.S. Department of Transportation (U.S. DOT) Class 3 flammable liquids by tank cars. Specifically, it compares the risks of HHFUTs and HHFTs for shipping a designated amount of hazmat and considers both mainline and yard operations in alignment with existing regulations and practical guidance. The methodology quantifies the transportation risk in total expected release consequence (i.e., casualties) given the total amount of Class 3 flammable liquids transported in HHFUT and HHFT configurations with different tank car placement strategies. Based on the case study, we find that using five 100-railcar HHFTs, each with 20 tank cars in positions 66 through 85, is both practical and generates the lowest transportation risk. Some hazmat railcar placement strategies in HHFTs lead to a higher release risk than HHFUT operations, while others result in a lower release risk. The proposed methodology could be extended to diverse operating scenarios to better understand the impacts of train configuration and tank car placement on the risk of rail transport for flammable liquids.
Toward Sustainability: A New Construction Method for Electrically Heated Rigid Pavement Systems
Authors: Abdel-Raheem Mohamed , Anis Mohammad
Published: September 2024

Damage caused by snow and ice to airport pavements in colder regions of the United States presents a persistent and economically significant challenge. This research explores an innovative construction method using an electrically conductive composite (ECC) composed of waterborne polyurethane and graphite powder (Gp). The ECC is applied to a Portland cement concrete substrate through a parallel stripe technique, using two types of “exposed” specimen. The study thoroughly examines the resistive heating performance of these specimens under various conditions, focusing on critical factors such as Gp concentrations in ECC, stripe thickness, spacing, and applied voltages. ECC was prepared with varying Gp concentrations (17.5% to 25%), and applied in strips of different thicknesses (1 mm, 2 mm, and 3 mm), with spacings of 15 cm and 20 cm. The specimens were subjected to alternating current voltages of 40, 50, and 60 V to measure surface heating performance. Tests were performed at room temperature (23.6°C) and a controlled sub-freezing temperature (−17°C), monitoring the surface temperature over 60 min to evaluate heating capacity and distribution. The time required for the specimens’ surface temperature to rise from −17°C to 0°C was recorded. Results indicated that ECC with 22.5% Gp content was the most effective, with exposed specimens showing a surface temperature increase of 19.94°C/h and sandwiched specimens showing 15.46°C/h. These findings suggest a promising sustainable alternative to traditional pavement heating methods, offering a viable and enduring solution for winter weather challenges on airport runways.
Association of Undercorrection With Residual Proinflammatory Gene Expressions and Clinical Outcomes After Medial Open Wedge Proximal Tibial Osteotomy
Authors: Yoshida Shigeo , Nishitani Kohei , Kuriyama Shinichi , Nakamura Shinichiro , Fujii Takayuki , Kobori Yu , Murata Koichi , Yoshitomi Hiroyuki , Matsuda Shuichi
Published: September 2024

Background:

Accumulating evidence suggests that synovial inflammation plays a pivotal role in knee osteoarthritis. Although biomechanical findings have shown that medial open-wedge proximal tibial osteotomy (OWPTO) decreases medial compartment loading by correcting knee alignment, the relationship between knee alignment and synovial inflammation in the biological microenvironment has not yet been elucidated.

Purposes:

To investigate the relationship between preoperative and postoperative knee alignment and synovial gene expression and to determine the cutoff point of postoperative knee alignment at which gene expression of synovial inflammation improves.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

A total of 36 patients with osteoarthritis who underwent OWPTO between June 2018 and May 2020 were enrolled. Synovial tissue was collected from affected knees during initial OWPTO and plate removal surgeries, and gene expression associated with the pathogenesis of osteoarthritis in the synovial tissue was investigated using real-time polymerase chain reaction. The correlation between weightbearing line ratio (WBLR) and synovial gene expression was determined. Receiver operating characteristic curve analysis was used to determine the cutoff values of WBLR for improving gene expression. The participants were divided into 2 groups, according to the cutoff values of their WBLR, and compared according to Knee injury and Osteoarthritis Outcome Score (KOOS) and synovial gene expression.

Results:

Postoperative WBLR was correlated with gene expression of interleukin 1β ( IL1B) (ρ = −0.43; P = .008) and of interleukin 6 ( IL6) (ρ = −0.41; P = .01). The cutoff value to predict improvement of IL6 was postoperative WBLR of 52%, with an area under the curve of 0.74 ( P = .03). Patients with WBLR of <52% showed higher postoperative inflammatory gene ( IL1B [ P = .04] and IL6 [ P = .03]) and inferior postoperative KOOS values compared with those with WBLR of >52%.

Conclusion:

The novel cutoff alignment for biological improvement after OWPTO in patients with medial compartment osteoarthritis was determined to be WBLR of 52%, and WBLR of <52% was associated with higher residual intra-articular inflammation and poor clinical outcomes. After accounting for surgical errors, the surgeon should set the target surgical alignment so that the postoperative WBLR does not fall below 52%.
Adverse Childhood Experiences and Symptom Severity in Social Anxiety Disorder: The Role of Emotion Regulation
Authors: Karaağaç Mustafa , İmre Okan
Published: September 2024

In this study, the relationship was examined of adverse childhood experiences (ACEs) with difficulties in emotion regulation and symptom severity in individuals with social anxiety disorder (SAD). The study included 71 patients diagnosed with SAD and a healthy control group of 73 subjects. Data for all the participants were collected using a sociodemographic data form, the Liebowitz Social Anxiety Scale, the Adverse Childhood Experiences-Turkish Form scale, and the Difficulties in Emotion Regulation Scale-16. The study results showed a higher probability of ACEs and difficulties in emotion regulation in the SAD group than in the control group. The difficulties in emotion regulation in the SAD group were correlated with symptom severity and these difficulties were found to play a mediating role between trauma and symptom severity. It was emphasized that emotion regulation skills were an important factor in the treatment of SAD patients. It can be suggested that therapies and interventions to develop emotion regulation skills could be effective in the management of SAD symptoms. It was thus concluded that ACEs and difficulties in emotion regulation are associated with SAD symptoms and should be taken into consideration in treatment. This study emphasizes the importance of emotion regulation skills for SAD treatment and can be considered to be of guidance for future studies.
Study of wear test and wear-resistant mechanism of bionic non-smooth groove side in line pan
Authors: Qiao Lindong , Xia Rui , Li Bo , Wang Xuewen , Ma Haozhou
Published: September 2024

Due to the impact and friction of coal bulk for a long time, the wear of groove side of scraper conveyor is extremely severe. This significantly reduces the service life of groove side and coal mining efficiency of scraper conveyor. There is an urgent need for an effective wear-resistant method to address the severe wear of groove side. This study aims to investigate the effects of five factors (diameter, depth, horizontal distance, vertical distance, arrangement angle) of the bionic pit structures on wear loss of groove side. Wear tests were designed to explore the effects of combination of different factors on three-body wear condition on groove side. Response surface methodology (RSM) test results showed that an increase in diameter reduces wear loss. Increases in vertical distance and depth increase wear loss. Diameter and vertical distance have an interactive effect on wear loss. The effects of horizontal distance and arrangement angle on wear loss of samples were insignificant. The optimal factors combinations are as follows: diameter is 1.62 mm, vertical distance is 9.01 mm and depth is 0.97 mm. The wear reduction rate of groove side reaches 36.6% with the optimal bionic structure. Combining test results, the wear morphologies of groove side were observed to analyze the wear-resistance mechanism. The pit structures have the function of reducing the friction contact area, storing the coal bulk particles and metal abrasive debris, easing the stress state of the samples, and improving the movement state of the coal bulk. This study can provide basis for wear-resistant design of scraper conveyor, prolong the service life of groove side and improve efficiency of mining machinery equipment.
Treatment adherence and quality of life in colombian patients with lupus nephritis
Authors: Domínguez-Vargas Alex , González-Torres Henry , Martínez-Bayona Álvaro , Sanguino-Jaramillo María , Vélez-Verbel María , Cadena-Bonfanti Andrés , Musso Carlos Guido , Depine Santos , Egea Eduardo , Aroca-Martínez Gustavo
Published: September 2024

Background

As with many other chronic diseases, systemic lupus erythematosus (SLE) and lupus nephritis (LN) have significant impacts on the health-related quality of life (HRQoL). Medication non-adherence is a significant challenge in the management of SLE, with consistently up to 75% of patients being non-adherent with their SLE medications. There is a need to assess the patient’s perspective using patient-reported outcomes (PROs) to better understand the current impact of LN on HRQoL and treatment adherence in our region. The aim of this study was to explore the relationship between HRQoL and treatment adherence in patients with LN from the Colombian Caribbean.

Methods

A cross-sectional study was conducted from June to December 2022, including patients with biopsy-proven LN. HRQoL and treatment adherence were assessed using the Lupus Quality of Life (LupusQoL) and the Compliance Questionnaire in Rheumatology 19 (CQR19) instruments, respectively. Patients were categorized as adherent or non-adherent based on medication intake (defined as >80% correct dosage). Principal component analysis (PCA) was employed to identify principal components between adherent and non-adherent patients.

Results

A total of 42 patients with LN were included. Of these, 38 (90%) were female, and the mean age was 31 ± 10 years. Proliferative class IV was the predominant histopathological profile (90%). Twenty-five (60%) patients were categorized as non-adherent. Across all LupusQoL domains, a comprehensive range of responses was observed. Pain, planning, and intimate relationships domains remained unaffected, while burden to others domain had the lowest score. Poorer planning score correlated with older age (r = −0.72; p < .05) and longer disease duration (r = −0.74; p < .05). SLEDAI-2 K correlated with the pain domain (r = −0.78; p < .05). Non-adherent patients exhibited significantly worse pain domain scores compared to adherent counterparts ( p < .05). PCA showed strong interactions between planning and pain, as well as between physical health and body image domains.

Conclusions

LupusQoL pain domain scores were significantly worse in non-adherent patients compared to adherent patients. Effective pain management could be a determinant in HRQoL and treatment adherence rates in our population.
Identification of common MicroRNAs expression signatures in antiphospholipid syndrome and thromboembolic disease: A scoping review
Authors: de Oliveira Vaz Camila , Cardoso Jacintho Bruna , de Mello Santos Gabrielle , de Oliveira José Diogo , Moraes Mazetto Bruna , Vieira Geraldo Murilo , Orsi Fernanda A
Published: September 2024

Background

Antiphospholipid syndrome (APS) is an acquired autoimmune disorder characterized by distinct pathophysiological mechanisms leading to heterogeneous manifestations, including venous and arterial thrombosis. Despite the lack of specific markers of thrombosis risk in APS, some of the mechanisms responsible for thrombosis in APS may overlap with those of other thromboembolic diseases. Understanding these similarities is important for improving the assessment of thrombosis risk in APS. MicroRNAs (MiRNAs) are RNA molecules that regulate gene expression and may influence the autoimmune response and coagulation.

Purpose

In this scoping review we aimed to investigate shared miRNAs profiles associated with APS and other thromboembolic diseases as a means of identifying markers indicative of a pro-thrombotic profile among patients with APS.

Data collection and Results

Through a comprehensive search of scientific databases, 45 relevant studies were identified out of 1020 references. miRs-124-3p, 125b-5p, 125a-5p, and 17-5p, were associated with APS and arterial thrombosis, while miRs-106a-5p, 146b-5p, 15a-5p, 222-3p, and 451a were associated with APS and venous thrombosis. Additionally, miR-126a-3p was associated with APS and both arterial and venous thrombosis.

Conclusion

We observed that APS shares a common miRNAs signature with non-APS related thrombosis, suggesting that miRNA expression profiles may serve as markers of thrombotic risk in APS. Further validation of a pro-thrombotic miRNA signature in APS is warranted to improve risk assessment, diagnosis, and management of APS.
Non-Pigmentary Applications of Aluminium Flakes
Authors: Wheeler Ian
Published: September 2024

Aluminium flakes are best known as pigments for paints, inks and plastics. There are nevertheless many existing and potential applications in which these pigmentary properties are of lesser or even no relevance. In such applications, the properties of aluminium metal itself can be more important than the shape or size of the flakes.

This paper considers non-pigmentary applications relevant to polymers. Some have already yielded commercially viable products. Others can be regarded as subjects for research and development. In total however, they should dispel the impression that aluminium flakes are only useful for their pigmentary properties.