bluuebunny/crossref_metadata_2025 huggingface dataset:
High-energy Radiation and Ion Acceleration in Three-dimensional Relativistic Magnetic Reconnection with Strong Synchrotron Cooling
Authors: Chernoglazov Alexander , Hakobyan Hayk , Philippov Alexander
Published: December 2023

We present the results of 3D particle-in-cell simulations that explore relativistic magnetic reconnection in pair plasma with strong synchrotron cooling and a small mass fraction of nonradiating ions. Our results demonstrate that the structure of the current sheet is highly sensitive to the dynamic efficiency of radiative cooling. Specifically, stronger cooling leads to more significant compression of the plasma and magnetic field within the plasmoids. We demonstrate that ions can be efficiently accelerated to energies exceeding the plasma magnetization parameter, ≫σ, and form a hard power-law energy distribution, f

i
∝ γ
−1. This conclusion implies a highly efficient proton acceleration in the magnetospheres of young pulsars. Conversely, the energies of pairs are limited to either σ in the strong cooling regime or the radiation burnoff limit, γ
syn, when cooling is weak. We find that the high-energy radiation from pairs above the synchrotron burnoff limit, ε

c
≈ 16 MeV, is only efficiently produced in the strong cooling regime, γ
syn < σ. In this regime, we find that the spectral cutoff scales as ε
cut ≈ ε

c
(σ/γ
syn) and the highest energy photons are beamed along the direction of the upstream magnetic field, consistent with the phenomenological models of gamma-ray emission from young pulsars. Furthermore, our results place constraints on the reconnection-driven models of gamma-ray flares in the Crab Nebula.
Kinetic Simulations of Nonrelativistic High-mach-number Perpendicular Shocks Propagating in a Turbulent Medium
Authors: Fulat Karol , Bohdan Artem , Torralba Paz Gabriel , Pohl Martin
Published: December 2023

Strong nonrelativistic shocks are known to accelerate particles up to relativistic energies. However, for diffusive shock acceleration, electrons must have a highly suprathermal energy, implying the need for very efficient preacceleration. Most published studies consider shocks propagating through homogeneous plasma, which is an unrealistic assumption for astrophysical environments. Using 2D3V particle-in-cell simulations, we investigate electron acceleration and heating processes at nonrelativistic high-Mach-number shocks in electron-ion plasma with a turbulent upstream medium. For this purpose, slabs of plasma with compressive turbulence are simulated separately and then inserted into shock simulations, which require matching of the plasma slabs at the interface. Using a novel procedure of matching electromagnetic fields and currents, we perform simulations of perpendicular shocks setting different intensities of density fluctuations (≲10%) in the upstream region. The new simulation technique provides a framework for studying shocks propagating in turbulent media. We explore the impact of the fluctuations on electron heating, the dynamics of upstream electrons, and the driving of plasma instabilities. Our results indicate that while the presence of turbulence enhances variations in the upstream magnetic field, their levels remain too low to significantly influence the behavior of electrons at perpendicular shocks.
Evidence for Low-power Radio Jet–ISM Interaction at 10 pc in the Dwarf AGN Host NGC 4395
Authors: Nandi Payel , Stalin C. S. , Saikia D. J. , Riffel Rogemar A. , Manna Arijit , Pal Sabyasachi , Dors O. L. , Wylezalek Dominika , Paliya Vaidehi S. , Saikia Payaswini , Dabhade Pratik , Patig Markus-Kissler , Sagar Ram
Published: December 2023

Black-hole-driven outflows in galaxies hosting active galactic nuclei (AGN) may interact with their interstellar medium (ISM) affecting star formation (SF). Such feedback processes, reminiscent of those seen in massive galaxies, have been reported recently in some dwarf galaxies. However, such studies have usually been on kiloparsec and larger scales and our knowledge of the smallest spatial scales to which these feedback processes can operate is unclear. Here we demonstrate radio jet−ISM interaction on the scale of an asymmetric triple radio structure of ∼10 pc size in NGC 4395. This triple radio structure is seen in the 15 GHz continuum image and the two asymmetric jet-like structures are situated on either side of the radio core that coincides with the optical Gaia position. The high-resolution radio image and the extended [O iii]λ5007 emission, indicative of an outflow, are spatially coincident and are consistent with the interpretation of a low-power radio jet interacting with the ISM. Modelling of the spectral lines using MAPPINGS, and estimation of temperature using optical integral field spectroscopic data suggest shock ionization of the gas. The continuum emission at 237 GHz, though weak, was found to spatially coincide with the AGN. However, the CO(2−1) line emission was found to be displaced by around 20 pc northward of the AGN core. The spatial coincidence of molecular H2
λ2.4085 along the jet direction, the morphology of ionized [O iii]λ5007, and displacement of the CO(2−1) emission argues for conditions less favorable for SF in the central ∼10 pc region.
Electromagnetic Characterization of the LISA Verification Binary ZTF J0526+5934
Authors: Kosakowski Alekzander , Kupfer Thomas , Bergeron P. , Littenberg Tyson B.
Published: December 2023

We present an analysis of new and archival data to the 20.506 minute LISA verification binary J052610.42+593445.32 (J0526+5934). Our joint spectroscopic and photometric analysis finds that the binary contains an unseen M
1 = 0.89 ± 0.11 M
⊙ CO-core white dwarf primary with an M
2 = 0.38 ± 0.07 M
⊙ post-core-burning subdwarf, or low-mass white dwarf, companion. Given the short orbital period and relatively large total binary mass, we find that LISA will detect this binary with signal-to-noise ratio 44 after 4 yr of observations. J0526+5934 is expected to merge within 1.8 ± 0.3 Myr and likely result in a D6 scenario Type Ia supernova or form a He-rich star that will evolve into a massive single white dwarf.
L'Europe, une œuvre de volonté
Authors: de Charentenay Pierre
Published: December 2023

Résumé L’Europe est une œuvre de la volonté et de la décision, une œuvre de la foi dans les capacités de l’homme à chercher et à construire la paix. C’est parce qu’elle a réussi ce pari qu’elle a reçu le Prix Nobel de la paix 2012. Pourtant avec le point de fixation de la crise, les débats sur l’Europe n’ont jamais été aussi intenses, non seulement sur les questions économiques et financières mais aussi sur les questions politiques.
Faut-il croire la science ?
Authors: Klein Étienne
Published: December 2023

Résumé La puissance de dévoilement de la science et l’impact des techno-sciences sur les modes de vie provoquent désormais des réactions de résistance qui semblent de plus en plus fortes, qu’elles soient d’ordre culturel, social ou idéologique. Ces résistances expriment tout autant l’inquiétude face à un processus de développement qui semble nous échapper que la volonté de préserver un débat démocratique face à la complexité des problèmes posés.
Évaluation des médecines alternatives
Authors: Gueullette o.p. Jean-Marie
Published: December 2023

Résumé Pour évaluer des pratiques thérapeutiques reposant sur des fondements différents de ceux de la bio-médecine occidentale, il est fréquent que soit mis en avant le critère de l’efficacité. S’il est justifié, afin de protéger les patients de l’escroquerie, ce critère ne tient pas compte de la spécificité de la demande des patients envers les alter-thérapeutes. Il est donc nécessaire d’explorer d’autres modalités d’évaluation.
La foi dans une culture mondialisée
Authors: Ravasi Cardinal Gianfranco , Gellard Jacques
Published: December 2023

Résumé Depuis les Apôtres, il est inhérent au christianisme de franchir les limites de l’espace protégé du temple et de la communauté et de s’ouvrir sur le monde, sur un panorama qui est aujourd’hui extrêmement fluide et complexe. Nous voudrions proposer ici quelques lieux importants du contexte interculturel contemporain où la foi est appelée à la confrontation, tels que l’interculturalité et la science.
L'exigence des noces
Authors: Lefebvre Philippe
Published: December 2023

Résumé La rencontre entre hommes et femmes ne constitue pas un thème comme un autre dans le texte biblique. Cela appartient à la substance de ce texte. On ne peut pas lire la Bible sans que les questions abordées ne s’expriment tôt ou tard dans une histoire où des hommes et des femmes sont engagés, se cherchent, se trouvent, se quittent.
Contre la « saine famille »
Authors: Hadjadj Fabrice
Published: December 2023

Il est probable que ce soit à partir des obscurs « liens du sang » que puisse naître l’amour le plus universel et le plus concret. Il s’agit précisément d’aimer ceux qu’on n’a pas choisis, ceux qu’on n’adopterait peut-être pas. C’est pourquoi les parents adoptifs conçoivent leur adoption sur le modèle de la parenté naturelle, et non sur celui d’un libre choix sur le marché des orphelins. C’est pourquoi, aussi, la charité trouve son analogie première dans les amours familiales les plus charnelles.
Développement durable et crise de la représentation
Authors: Renouard Cécile
Published: December 2023

Nos sociétés ont besoin des compétences des experts pour contribuer à résoudre les défis d’une mutation vers de nouveaux modèles de production, de consommation et de vie. Mais concernant le climat, l’aménagement du territoire, le financement de la transition énergétique, les enjeux actuels ne relèvent pas seulement des décisions éclairées de spécialistes. Ils méritent d’être largement débattus dans l’espace public, en faisant intervenir des critères de discernement éthique.
Le sens de la vie chez Hans Jonas
Authors: Pommier Éric
Published: December 2023

Hans Jonas naît en 1903 en Allemagne, quasiment avec le siècle dont il traversera les épreuves qui marqueront sa philosophie. La perception de son œuvre est rarement appréhendée dans sa continuité et dans son unité. Pourtant, fort d’une philosophie de la vie, il prend en charge les défis contemporains lancés par la technique en proposant une éthique originale de la responsabilité.
Chine : vision(s) de la tradition
Authors: Idier Nicolas
Published: December 2023

Rares sont les pays comme la Chine qui peuvent tout à la fois prétendre à une histoire culturelle dont on fait volontiers remonter l’horloge au troisième millénaire avant notre ère, et avoir construit leur modernité actuelle en rupture avec la notion même de tradition. Soulever ce paradoxe permet d’en examiner les nuances, mais également d’entrevoir des voies d’éclaircissement.
Somalie année zéro
Authors: Decherf Dominique
Published: December 2023

Après vingt-deux ans de guerre civile, la Somalie, « État failli », est redevenue un État internationalement reconnu même si elle reste un « État fragile ». Le processus de retour à une certaine normalité comporte des enseignements pour d’autres cas, par exemple celui du Mali aujourd’hui. La période de transition a pris officiellement fin le 20 août 2012. De quelle transition parle-t-on ? De quoi vers quoi ? Et comment ?
L'Église romaine face à son avenir
Authors: Chiron Jean-François
Published: December 2023

L’écho médiatique de la renonciation de Benoît XVI et de l’élection de son successeur François a pu surprendre par son ampleur. S’agit-il de l’intérêt manifesté à « la plus ancienne institution d’Occident » et à son représentant ou, plus profondément, de la fascination suscitée par une altérité ? Des interrogations s’expriment : le prochain pape fera-t-il évoluer l’Église ? Sera-t-il davantage en phase avec la modernité ?
Comment Internet m'a ré-appris pourquoi j'enseigne
Authors: Damour Franck
Published: December 2023

Dans quelles mesures Internet change-t-il les apprentissages des élèves et le métier de professeur ? Dans toutes ces transformations, le professeur, embarqué avec ses élèves, se voit renforcé dans son rôle d’éducateur et d’initiateur. Il peut reconquérir ou cultiver son statut de « maître savant », non pas contre la culture numérique mais avec elle.
La première réforme, le style chrétien
Authors: François Pape , Euvé François , Nicq Hervé
Published: December 2023

Le risque de chercher et trouver Dieu en toutes choses est la volonté de trop expliciter, de dire avec certitude humaine et arrogance : « Dieu est ici. » Nous trouverons seulement un dieu à notre mesure. L’attitude correcte est celle de saint Augustin : chercher Dieu pour le trouver et le trouver pour le chercher toujours. Si le chrétien est légaliste ou cherche la restauration, s’il veut que tout soit clair et sûr, alors il ne trouvera rien.
Navigating Fieldwork in Egypt’s Nile Delta
Authors: El-Kouny Nada
Published: December 2023

Cet article traite de l’expérience de recherche ethnographique et archivistique que j’ai vécue en Égypte, entre 2014 et 2018, dans le cadre de ma thèse de doctorat. J’y traite de ma rencontre avec mon premier terrain, un village du gouvernorat de Daqahliya en Égypte dans lequel j’ai séjourné en tant que journaliste après 2011. Ce séjour coïncide avec une période d’ouverture politique relative vis-à-vis des journalistes et des chercheurs. Je décris ensuite comment, à partir de 2016, l’accès à ce site de recherche devient impossible du fait de menaces sur ma sécurité et celle de mes interlocuteurs, ce qui m’amène à déplacer mes recherches vers un autre gouvernorat du delta du Nil, celui de Beheira. Ce changement de terrain signifie que ma recherche s’est dorénavant déroulée dans un village d’où ma famille est originaire et où plusieurs membres de la famille résident toujours. Le passage d’un village que j’avais côtoyé pour la première fois en tant que journaliste-chercheuse à un village d’où ma famille est originaire, s’est accompagné d’un changement dans les rapports avec mes interlocuteurs. Il a également entraîné un changement des formes de surveillance limitant mes recherches : d’une surveillance sécuritaire au contrôle familial. Cet article se penche donc sur les défis de l’enquête de terrain menée dans un contexte égyptien marqué par la répression politique et par le ciblage des chercheurs et chercheuses. Compte tenu de ces contraintes, l’article interroge aussi les moyens de surmonter ces défis lorsqu’on mène des recherches ethnographiques et archivistiques.
La guerre de demain sera-t-elle juste ? Soldat augmenté et éthique de la guerre
Authors: Bourgois Pierre
Published: December 2023

Quels sont les enjeux éthiques de l’augmentation militaire ? Plus particulièrement, quel est l’impact du phénomène sur la doctrine de la guerre juste ? Cet article fait le choix d’aborder la thématique du soldat augmenté sous l’angle spécifique de l’éthique de la guerre. Il s’agira, ainsi, de s’interroger sur ses possibles conséquences pour le jus ad bellum (entrée dans le conflit), le jus in bello (conduite du conflit) ainsi que le jus post bellum (après le conflit). Pour cela, les avantages comme les dangers représentés par le super soldat doivent être mis en lumière au niveau de ces trois dimensions. Le propos vise, par conséquent, à présenter une vue d’ensemble et équilibrée des potentiels effets du soldat augmenté à ce sujet, condition fondamentale pour une décision la plus éclairée possible concernant son encadrement nécessaire.
Hume et l'utilité
Authors: Cléro Jean-Pierre
Published: December 2023

Hume est-il utilitariste ? Bentham n'a pas hésité à lui faire une place de choix dans ses deux articles sur l'utilitarisme. Mais, s'il est utilitariste, il l'est surtout dans l'Enquête sur les principes de la morale, qui fait suite au Traité de la nature humaine ; et il n'entend certainement pas l'utilité comme un utilitariste de la fin du siècle. L'utilitarisme de l'auteur n'est pas de la sorte qui se puisse calculer ; Hume n'est pas philosophe à laisser réduire toutes les valeurs à une seule, à la différence de ce qui se passera dans l'utilitarisme classique. Quant à l'aspect "senti" de l'utilité, il est constamment plus marqué chez Hume que chez Bentham, qui met plutôt l'accent sur le caractère structurant du langage. Toutefois, si la différence est profonde et modale, de Hume à Bentham, elle permet très facilement d'éclairer l'une des philosophies par l'autre, le commun dénominateur étant assuré par le commun signifiant de l'utile.
Distributed consensus of discrete time-varying linear multi-agent systems with event-triggered intermittent control
Authors: Gu Mingxia , Yu Zhiyong , Jiang Haijun , Huang Da
Published: December 2023

The consensus problem of discrete time-varying linear multi-agent systems (MASs) is studied in this paper. First, an event-triggered intermittent control (ETIC) protocol is designed, aided by a class of auxiliary functions. Under this protocol, some sufficient conditions for all agents to achieve consensus are established by constructing an error dynamical system and applying the Lyapunov function. Second, in order to further reduce the communication burden, an improved event triggered intermittent control (I-ETIC) strategy is presented, along with corresponding convergence analysis. Notably, the difference between the two control protocols lies in the fact that the former protocol only determines when to control or not based on the trigger conditions, while the latter, building upon this, designs new event trigger conditions for the update of the controller during the control stage. Finally, two numerical simulation examples are provided to demonstrate the effectiveness of the theoretical results.
El trazado geométrico del ábside del gótico meridional de la catedral de Tortosa.
Authors: Lluis-Teruel Cinta , Lluis i Ginovart Josep
Published: December 2023

El análisis estadístico del resultado de los levantamientos realizados con láser escáner terrestre (TLS) en la catedral gótica meridional de Tortosa (1383), ha permitido demostrar que el trazado metrológico de su ábside tetradecagonal tiene una precisión metodológica del [± 1,502%]. Analíticamente, se determina que, dentro del rango de precisión, el ancho total de la girola es de 150 palmos, y que las capillas radiales tienen una dimensión de 24 palmos que son 3 canas, proporción tonal (9:8) respecto a la medida de la nave lateral de 27 palmos. La clave se sitúa a 100 palmos, y su sección final dispone de una relación (3:2) entre el ancho del deambulatorio de 150 palmos y su altura. Como conclusión, se observa una conjunción proporcional entre el orden medieval y la fábrica gótica. Las proporciones de la catedral de Tortosa forman parte de la tradición del Timeo, que bien conocían sus promotores, diferente a la de los maestros góticos septentrionales, con modelos de sección ad triangulum (1:√3/2) y ad quadratum (1:1) definidos en los debates de la catedral de Milán.
The Cyberfeminism Index Project: A Critical Exploration of its Evolution, as Well as the Development of the Website and Book that Support It
Authors: Atzmon Leslie C , Seu Mindy , Coombs Laura
Published: December 2023

In this essay, Dialectic Associate Editor Leslie Atzmon interviews designers Mindy Seu and Laura Coombs, who collaborated on the design of the Cyberfeminism Index website and book. Cyberfeminism Index is a crowd-sourced, constantly evolving gathering of online activism and net art. The site (cyberfeminismindex.com) includes over 700 posts from a diverse international group of hackers, scholars, artists, and activists. Seu and Coombs published a snapshot of the online index in printed form. These posts feature "techno-critical activism in a variety of media," according to the book publisher Inventory Press, "including excerpts from academic articles and scholarly texts; descriptions of hackerspaces, digital rights activist groups, and bio-hacktivism; and depictions of feminist net art and new media art."a In this conversation, the two designers discuss the evolution of the project as well as the design of the site and book. (According to Megan Jean Harlow in her book The Multimedia Encyclopedia of Women in Today's World, Second Edition, "Cyberfeminism is a feminist approach which foregrounds the relationship between cyberspace, the internet, and technology. It can be used to refer to a philosophy, methodology or community."b Interviewees Coombs and Seu both also offer their definitions of cyberfeminism in the ensuing interview.)
What Does the Transition from Publishing to Data Analytics Mean for Libraries?
Authors: Lamdan Sarah , Mann Sanjeet
Published: December 2023

Data analytics is the process by which meaning is extracted from large, structured information sets using computer algorithms to draw conclusions and identify patterns. In her NASIG Vision Session, Sarah Lamdan of City University of New York (CUNY) School of Law explains how some library vendors are consolidating and developing new business models involving the sale of predictive and prescriptive analytics products to new, non-library customers. Large vendors are increasingly able to exert monopoly power over information industries, posing risks to the public good and challenges for libraries interested in securing patronsâ€™ privacy and contracting for necessary resources. Lamdan highlights scholars and initiatives working to expose the drawbacks of this trend in contemporary information capitalism and mitigate its potential harms.
An Interesting Case of Takayasu’s Arteritis
Authors: Tadakal Vishwaraj , Mangane Arun D.
Published: December 2023

Takayasu’s arteritis is an inflammatory and stenotic disease of medium- and large-sized arteries characterized by a strong predilection for the aortic arch and its branches. Takayasu’s arteritis is an uncommon disease with an estimated annual incidence rate of 1.2–2.6 cases per million. It is most prevalent in adolescent girls and young women. Although it is more common in Asia, it is neither racially nor geographically restricted. This is a case report of a 58-year-old male patient who presented with syncopal attack and weakness in the right lower limb. He had a history of cerebrovascular accident (CVA) 10 years back with right upper limb monoparesis. Patient had feeble pulses in bilateral upper limb and absent pulsations in the right lower limb and left lower limb. Carotid pulsations were absent on the left side. Upper limb Doppler showed dampened and monophasic flow in ulnar and radial artery on both upper limbs. Dampened and monophasic flow in the right leg arterial system and posterior tibial artery of the left lower limb.
Recurrent Postpartum Hemorrhage: A Case of Uterine Artery Pseudoaneurysm Probably Induced by Anticoagulants
Authors: Jha* Sangam , Jha Sharda , Praveena Pammy , Brightsingh Jafeesha
Published: December 2023

Pseudoaneurysm formation often occurs when there is inadequate sealing at an arterial puncture site. We present the case of a 27-year-old primigravida with rheumatic heart disease and a history of mitral valve replacement on anticoagulants who experienced recurrent episodes of postpartum hemorrhage (PPH). Despite conservative management and adjustments to anticoagulant therapy, the bleeding persisted. Further investigations revealed a small pseudoaneurysm originating from the left uterine artery. Bilateral uterine artery embolization (UAE) using polyvinyl alcohol particles was successfully performed. The patient’s condition improved, and she was discharged on a carefully regulated medication regimen. This case highlights the importance of considering rare causes of PPH in high-risk patients, such as uterine artery pseudoaneurysm. Anticoagulants could be a potential contributor of its spontaneous rupture. Prompt diagnosis and appropriate intervention, such as UAE, can effectively manage PPH and prevent adverse outcomes.
Efficacy and safety of apatinib for elderly patients with previously treated extensive-stage colorectal cancer patients and the prognostic significance of common adverse reactions
Authors: Yu Yongjun , Li Yuwei , Xu Chen , Zhang Weihua
Published: December 2023

Background:

This study was designed to investigate the efficacy and safety of apatinib monotherapy in the treatment of elderly patients with advanced colorectal cancer (CRC) who have progressed on the standard regimens.

Methods:

The data of 106 elderly patients with advanced CRC who have progressed on standard treatment were analyzed. The primary endpoint of this study was progression-free survival (PFS), the secondary endpoints were objective response rate (ORR), disease control rate (DCR), and overall survival (OS). The safety outcomes were assessed by the proportion and severity of adverse events.

Results:

Efficacy was assessed using the best overall response of patients during treatment with apatinib, including 0 patients with complete response, 9 patients with partial response, 68 patients with stable disease, and 29 patients with progressive disease. ORR and DCR were 8.5 and 72.6%, respectively. The median PFS of 106 patients was 3.6 months, and the median OS was 10.1 months. The most frequent adverse reactions of elderly patients with advanced CRC receiving apatinib treatment were hypertension (59.4%) and hand–foot syndrome (HFS) (48.1%). The median PFS of patients with and without hypertension was 5.0 and 3.0 months, respectively (P = 0.008). The median PFS of patients with and without HFS was 5.4 and 3.0 months, respectively (P = 0.013).

Conclusions:

The clinical benefit of apatinib monotherapy was observed in elderly patients with advanced CRC who have progressed on the standard regimens. The adverse reactions of hypertension and HFS were positively related to treatment efficacy.
Association of molecular subgroups with pathological parameters in endometrial carcinomas
Authors: Ratnakaran Nirosha , Nair Indu R , Rajanbabu Anupama , Patel Viral , Ariyannur Prasanth S , Kamalasanan Sukrishna
Published: December 2023

Background:

The integration of molecular features into the already existing pathological classification of endometrial carcinomas will offer significant prognostic information. As the literature search reveals, there are no studies from India that have classified these carcinomas based on molecular subtypes. The aim of the study was to classify endometrial carcinomas into four subtypes based on their molecular and immunohistochemical features and to find out the association of each of these molecular subtypes with the other pathological parameters.

Methods:

A prospective study was done on 37 consecutive cases of fresh hysterectomy specimens, biopsy-proven as endometrial carcinomas between November 2019 and August 2020. Three immunohistochemical markers (p53, mismatch repair proteins, MutS homolog6 and Postmeiotic seggregation 2 respectively[MSH6, and PMS2]), along with DNA (deoxyribonucleic acid) sequencing of selected regions of the POLE gene was performed in each of the 37 cases. Endometrial carcinomas were subclassified into four subtypes, and the association of each of these four subtypes with the other pathological parameters was also explored. Statistical analysis was done using the IBM Statistical Package for the Social Science (SPSS) Version 20.0 software (IBM SPSS, USA).

Results:

Among the 37 cases studied, eight (21.6%) cases were p53 abnormal, eight (21.6%) cases showed MMR-D (mismatch repair deficient), one case (2.7%) showed mutation of POLE, and 21 cases (56.8%) were assembled under p53 wild-type. Higher grade endometrial carcinomas showed more (80.0%) p53 abnormal (P < 0.001). All the p53 wild-type (100%) were of Type 1 endometrial carcinoma subtype (P = 0.001) and low-grade type (90.5%; P = 0.005).

Conclusion:

Our study confirms that the type of carcinoma and grade correlates with p53 expression, p53 abnormal being associated with higher grade and type 2 endometrial carcinomas, whereas p53 wild-type is associated with low-grade and type 1 endometrial carcinoma. There was only one case of the POLE subtype identifiable in our study.
Neo-carina after carina resection and right upper lobectomy in a patient with adenoid cystic carcinoma: Alternative technique
Authors: Beyoglu Muhammet A. , Sahin Mehmet F. , Yazicioglu Alkin , Yekeler Erdal
Published: December 2023

Surgical treatment of carinal tumors that extend into the lobar bronchus is a procedure that challenges thoracic surgeons. There is no consensus on the suitable technique for a safe anastomosis in lobar lung resection with carina. The preferred Barclay technique has a high rate of anastomosis-related complications. Although a lobe-sparing end-to-end anastomosis technique has been previously described, the double-barrel method can be applied as an alternative technique. We present a case where we performed double-barrel anastomosis and neo-carina formation after tracheal sleeve right upper lobectomy.
Quality of life and shoulder function among oral cancer patients treated with selective neck dissection: A cross-sectional study
Authors: Karthikeyan Gramani Radhan , Venkatramanaiah C , Balasubramaniyam Balaguhan , Aiyathurai Mathanmohan , Velu Deepak , Indrapriyadharshini K
Published: December 2023

Background:

There is no doubt about the oncologic effectiveness of neck dissections (NDs). But the quality of life (QoL) of patients with oral cancer and the morbidity associated with ND like shoulder dysfunction remain uncertain. The present study aimed to assess the postoperative ND-related QoL and shoulder function of oral cancer patients who underwent selective neck dissection (SND).

Methods:

A cross-sectional study was conducted by using a self-administered, ND-related QoL questionnaire and arm abduction test (AAT) in 128 patients who had undergone only SND (up to Level IV) for oral cancer.

Results:

Out of the 128 patients, 94 (73.8%) patients had better QoL, and 34 (26.2%) patients had worse QoL. Fifty-one (39.84%) participants were able to abduct up to or more than 150° but less than 180° (Score 3) followed by 31 (24.22%) participants who could abduct up to or more than 90° but not less than 150° (Score 2). Strong positive correlations (r = 1.000) were observed between the ND QoL scores and the AAT scores. It was found to be statistically significant (P = 0.000).

Conclusion:

SND, being a more conservative approach sparing the spinal accessory nerve, could still limit the QoL and could affect the shoulder function to a certain extent.
Evaluation of ozonated olive gel in treatment of chronic osteomyelitis of the jaws in diabetic patients
Authors: Saleh Heba Ali Mohamed , Khedr Mohamed M. S. , Saad Khalid A. El Hamiid , Allam Mohamed K. Eid Elsayed
Published: December 2023

Purpose

This study was planned to evaluate clinically and radiographically the use of ozonated olive gel in the treatment of chronic osteomyelitis of the jaws in diabetic patients.

Patients and methods

This prospective study that was carried out on twenty controlled diabetic patients with osteomyelitis of the jaws and were divided randomly into two equal groups. Group 1 (study group): included 10 patients were treated by surgical debridement and systemic antimicrobial therapy with topical application of ozonated olive gel. Group II (control group): comprised of 10 patients were treated by surgical debridement and systemic antimicrobial therapy only. All Patients underwent regular follow-ups clinically and radiographically for six months.

Results

Clinically, there was a significant decrease in postoperative pain and enhancement of wound healing in the study group. There was no significant difference in edema between both groups. Radiographically, by CBCT there was a significant increase in bone height gain and bone density in the study group at P value <0.05.

Conclusion

This study showed significant effect of ozone gel on pain, soft tissue healing and elimination of infection as well as significant increase in bone height gain and bone density.
Equal-Sum-Product problem II
Authors: Zakarczemny Maciej
Published: December 2023

In this paper, we present the results related to a problem posed by Andrzej Schinzel. Does the number
$N_1(n)$
of integer solutions of the equation
$$ \begin{align*}x_1+x_2+\cdots+x_n=x_1x_2\cdot\ldots\cdot x_n,\,\,x_1\ge x_2\ge\cdots\ge x_n\ge 1\end{align*} $$
tend to infinity with n? Let a be a positive integer. We give a lower bound on the number of integer solutions,
$N_a(n)$
, to the equation
$$ \begin{align*}x_1+x_2+\cdots+x_n=ax_1x_2\cdot\ldots\cdot x_n,\,\, x_1\ge x_2\ge\cdots\ge x_n\ge 1.\end{align*} $$
We show that if
$N_2(n)=1$
, then the number
$2n-3$
is prime. The average behavior of
$N_2(n)$
is studied. We prove that the set
$\{n:N_2(n)\le k,\,n\ge 2\}$
has zero natural density.
Continuous investigation of the nasal cycle over 48 hours
Authors: Lindemann J , Scheithauer M O , Sommer F , Hoffmann T K , Hahn J , Foerg J
Published: December 2023

BACKGROUND: Previous results on the nasal cycle refer to measurements over up to 24h. The long-term rhinoflowmetry (LRFM) allows continuous observations over a longer period. The aim of the study was to observe the nasal cycle for the first time over 48h under everyday conditions.METHODOLOGY: The LRFM was continuously applied to 30 rhinologically healthy subjects (20 female, 10 male) over 48h. The different types of nasal cycle were classified as follows: "classic", "in concert", "one-sided", "no-cycle" and "mixed”. The focus of this study was on the results over the entire 48 hours. The comparison of the two consecutive days was also made. RESULTS: A nasal cycle could be detected in 100% of the subjects over 48h. With 97%, the mixed type most commonly occurred as a combination of classical and in concert components. In all subjects, classical cycle components could be detected at least once. The no-cycle type was not observed. In the awake state, the mixed type dominated (80%), as a combination of classical and in concert parts. In the sleep state, the classical type was the most common type (97%). The average phase duration was 206 ± 83 minutes. CONCLUSIONS: In the very first continuous 48-hour study on the nasal cycle, 100% of the subjects presented a nasal cycle. The LRFM method is the only one that offers the possibility to perform continuous measurements over a longer period during daily routine. The results of previous single-stage examination methods should thus be questioned.
Optimizing the Design Parameters and Nanoclay Content of Thin GLARE
Laminate Riveted Joints under Pull-Through Test Using Grey Relational
Analysis
Authors: Sabarilal Krishnan K. , Hariharasakthisudhan P. , Logesh K. , Kannan Sathish
Published: December 2023

The study investigates the optimization of design parameters of riveted joints
such as diameter of rivet, edge distance, and the amount of nanoclay filler in
the modified GLARE laminate single lap riveted joints under pull-through test.
Taguchi’s L9 orthogonal array was used to plan the experiments. The failure
mechanism of riveted joints was observed to be elongation of rivet hole,
followed by stress concentration, crack initiation, propagation in the
interface, coalition of multiple cracks leading to delamination in the laminate.
The failure of joint finally occurred by rivet pin fracture. The regression
equations were developed for both failure load and maximum displacements with
prominent level of confidence and the reliability of the equations were
confirmed by experiments. The effect of individual and interaction of factors
was evaluated using analysis of variance (ANOVA). The grey relational analysis
(GRA) was conducted to determine the optimum combination of factors and levels.
The GRA predicted the combination of factors and levels as “A3 (Diameter of
rivet – 6.4 mm) -B3 (Edge distance – 35 mm) -C3 (Nanoclay wt.% - 5).”
USCAR Inflator Technical Requirements and Validation
Authors:   USCAR
Published: December 2023

This specification establishes the performance and validation requirements for the inflator assembly used in airbag modules.
Cloning and Extracellular Expression of Glargine in Pichia pastoris
Authors: Hardianto Dudi , Martius Efrida , Rostinawati Tina , Safarrida Anna , Royani Juwartina Ida , Assyifa Fahroziah , Laziba Dihan
Published: December 2023

Patients with diabetes mellitus increase significantly every year. The increasing number of people with diabetes mellitus results in increased insulin requirements. There are two types of insulin used for diabetes mellitus treatment: human insulin and insulin analogues. Escherichia coli, Pichia pastoris, Saccharomyces cerevisiae, or Hansenula polymorpaha has been used to produce human insulin and insulin analogues. Pichia pastoris can produce glargine in large quantities, and the insulin protein produced will be secreted outside the cell to facilitate the purification process. The advantage of glargine has a long working time of up to 24 hours. Hence, glargine is more effective because patients with diabetes receive glargine injections only once daily. The research started with cloning the glargine gene, transforming pPICZαA-G plasmid into Pichia pastoris, and testing glargine production. 20 recombinant Pichia pastoris colonies were selected and regenerated. Eight recombinant Pichia pastoris colonies were tested for glargine production, and six colonies were detected producing glargine by electrophoresis SDS-PAGE gel stained with Coomassie blue. This study aims to produce glargine using Pichia pastoris as an expression system capable of producing glargine extracellularly, thus simplifying the purification process.
The Toxicity Test of Synthetic Insecticides on Tetragonula laeviceps (Apidae: Meliponini)
Authors: Hasanah Ina Rubiatul , Mubin Nadzirum , Sartiami Dewi , Priawandiputra Windra , Dadang
Published: December 2023

Intense insecticide application is thought to cause a decline in bee colonies worldwide. Bees are effective pollinators in increasing the production of agricultural commodities. The stingless bee Tetragonula laeviceps (Apidae: Meliponini) is widely cultivated and found around plantations. The insecticides used in the toxicity test were imidacloprid 200 g/L, fipronil 50 g/L, lambda-cyhalothrin 25 g/L, profenofos 500 g/L, and chlorantraniliprole 50 g/L followed by a semi-field test using imidacloprid, fipronil, and profenofos insecticides on the cucumber plant. The LC50 value showed that exposure to imidacloprid, fipronil, and profenofos insecticides caused toxic effects on T. laeviceps by contact and orally. Lambda-cyhalothrin was found harmful on contact exposure, in contrast, chlorantraniliprole was harmful through oral. Classification of insecticide toxicity based on LD50 contact for imidacloprid, fipronil, lambda-cyhalothrin, and profenofos were very toxic and needed a risk assessment. However, chlorantraniliprole was classified as moderately toxic and low risk. In semi-field test results, imidacloprid and fipronil insecticides caused a significant decrease in the leave-return and bee-visiting activity on cucumber flowers. These insecticides also produced a low average yield of fruit weight. Insecticide application can affect the role of T. laeviceps as the pollinator which impacts the production of agricultural commodities.
Prospects of Indigenous Bacillus subtilis Strain LS9.1 as a Potential Biocontrol Agent against Aedes aegypti Larvae
Authors: Salamun Salamun , Ni'matuzahroh Ni'matuzahroh , Fatimah Fatimah , Nurhariyati Tri , Supriyanto Agus , Tsana Izdihar , Nafidiastri Farah Aisyah
Published: December 2023

Biocontrol is one way that can be developed to overcome public health and agricultural problems. Biocontrol agents could be a microorganism, for example, from the Bacillus group. This study aims to determine the larvicidal toxicity of the Bacillus subtilis strain LS9.1 against Aedes aegypti larvae. The mode of action of the isolate caused larval death, which was detected with parasporal inclusions and secondary metabolites. Larvicidal toxicity with the bioassay method. Parasporal inclusion proteins were detected with the SDS-PAGE method. The Cry toxin coding gene with the PCR method and cell ultrastructure with transmission and scanning electron microscopy (TEM and SEM). The action of secondary metabolites was detected with hemolytic activity test. The isolate high toxicity to A. aegypti larvae. Parasporal inclusion proteins with molecular weights ranging from 72-7 kDa and the gene encoding a protein toxin in size 300 bp. The TEM and SEM results did not Cry-IV toxin. The hemolytic activity test showed a positive reaction correlated with biosurfactant production. Based on this study, the death of larvae is probably caused by secondary metabolites produced by Bacillus subtilis strain LS9.1. Thus, this isolate has the prospect of being an environmentally friendly biocontrol agent to disease vectors and insect pests.
Sequence-Structure Based Comparison of Structurally Homologous Thermophilic and Mesophilic Polyethylene Terephthalate (PET) Hydrolases
Authors: Hasan Khomaini , Ulfah Maria , Nurhayati Niknik , Sabbathini Gabriela Christy , Wulandari Sri Rezeki , Putra I Gede Eka Perdana , Helianti Is
Published: December 2023

Protein structure has a direct impact on thermostability. Deviations in the primary sequence can affect structural changes, leading to alterations in thermostability properties. However, the molecular basis of protein thermostability is unspecified; thus, elucidation of key factors that role particular protein thermostability is required when engineering proteins to be thermostable. To address this challenge, the amino acid composition, hydrophobicity/hydrophilicity ratio, cysteine bridges, and intrinsic features of two structurally homologous but different thermostability, poly(ethylene terephthalate) hydrolase (PETase) were compared. According to the findings, thermostable and thermolabile PETases have similar folds, compactness, and disulfide bridges. Interestingly, an abundance gap of aromaticity, hydrophobic cluster area, polar amino acid and hydrogen bond network compositions demonstrated dominant trends of variations for both PET hydrolases, indicating a pivotal role of these features in the thermostability of PET hydrolase. Furthermore, increased hydrophobic amino acid frequency in the inner surface of thermostable proteins contributed significantly to thermostability by forming more internal hydrophobic interactions and a less hydrophobic patch. There are no consistent trends in insertions and deletions between both PETases. Taken together, these observations demonstrate that hydrophobicity and hydrogen bond networks are essential factors in thermostability of thermostable PETase.
Viewable Terrestrial Mammals along the Nature Trails at the Lowland Tropical Forests of Western Sabah, Malaysia Borneo
Authors: Lim Wing Shen , Mojiol Andy Russel , Bernard Henry , Matunjau Christopher A. , Nair Guptah V. G.
Published: December 2023

The information related to the species of terrestrial mammals that can be detected along the nature trails established in the lowland tropical forests of Western Sabah remains scarce at this moment. The camera trapping surveys were commenced at the Tenghilan Community Forest (TCF), Kawang Forest Reserve (KFR), and the urban forest of Universiti Malaysia Sabah (UMS) to investigate the terrestrial mammal species that could be observed along the local trails. A total of 20 terrestrial mammal species belonging to 13 different families were observed in 2,077 trap nights, where most of them were validated to be non-threatened (n = 16 or 80.0%) and omnivorous (n = 13 or 65.0%) species. Twelve species were found along the nature trails in TCF (H’ = 2.223; 1-D = 0.8650) and KFR (H’ = 1.730; 1-D = 0.7078), whereas seven species were detected along the trails in the urban forest of UMS (H’ = 1.217; 1-D = 0.5567). The differences in the mammalian composition, diversity richness, and distribution evenness between these three study sites were validated as significant (p<0.05). The present findings emphasize that these three study sites are favorable habitats for four threatened species. Hence, conservation efforts are needed to protect these terrestrial mammal species from facing extinction risks in future.
Women Exclusion in Nigerian Politics: A Historical Re-Evaluation
Authors: Jacob Uche , Nwigwe Nneka , Ikedinma Amoge
Published: December 2023

The systemic exclusion of women and minority groups in Nigeria’s politics have contributed to the underdevelopment crisis in the country. Starting from the 1954 elections, the women remained underrepresented in both elective and appointive positions. At independence in 1960, the trend continued as the nationalists struggled to undo the damages of colonialism. It is regrettable to note, that, while the women played significant roles in the decolonization and nation-building process, however, their rights for equal representation were systemically undermined in a supposedly secular country where equality should be a fundamental principle shaping the society. Numerous studies in this field agree that women are potential asset in nation-building and as such must be given the opportunity to contribute to that process. This accounts for why women rank highest among the unemployed persons in the country, they are the least considered when distributing power or during allocation of political positions, and for more than fifty years in Nigeria, women have remained the most vulnerable in the country, often ranking highest in the poverty index annually. Based on the foregoing, the paper sought to critically re-evaluate the historical trajectories of women exclusion in Nigeria’s politics to reposition the women and minority groups as principal actors in the political development of the country. It argued that, the system of exclusive governance was not an indigenous idea, but a colonial legacy which took practical expression in the Indirect Rule policy of the British. Data used for this study were collected through the qualitative method, which allowed for the use of secondary and primary sources. Secondary data used include books and journal articles. While primary materials were gathered using newspapers, official memos, recorded interviews and videos. The combination of primary and secondary data provided a balanced analysis of the phenomenon being studied.  A theory of exclusion informed the theoretical argument of the paper, which holds that when individuals or groups in a society are denied their rights, it results to resistance, protests or conflicts that could potentially destabilize the nation.  Consequently, the paper found that Nigeria’s political development has continued to suffer unprecedented setback due largely for the failures of successive regimes to adopt inclusive governance, which supports equal participation in politics. It concluded that, the racial discrimination of the British colonial officials rubbed-off on Nigerian political class who could not revert to the morals that govern the traditional African society in the pre-colonial time; built on communal living and inclusiveness.
Phytoremediation Potential of Watermelon (Citrullus lanatus) Seedlings Planted on Lead Contaminated Soil in Katsina, Nigeria
Authors: Usman N. , Jalo A. , Tahir N. , Usman Z. H.
Published: December 2023

The objectives of this study is to investigate the phytoremediation potential of watermelon (Citrullus lanatus) seedlings planted on lead contaminated soil in Katsina, Nigeria using appropriate standard methods of physicochemical properties of the soil before and after the experiment and Atomic Absorption Spectrophotometer (AAS) measurements for Pb concentrations. The result revealed that the plant had accumulated a significant concentration of Lead in the leaves (18.112mg/kg), shoot (14.221mg/kg) and roots (9.100mg/kg) and there was no significant difference in the concentrations of Lead used in the study at p>0.05. The phytoextraction ability of C. lanatus was assessed in %remediation factor (RF), Bioconcentration factor (BCF) and elemental translocation factor (TF). The amount of Lead in the shoots and roots after 6weeks showed that more concentration of Lead was translocated from the roots to the leaves. The results of this investigation suggests that Citrullus lanatus could be used for phytoextraction of Lead from contaminated soil.