bluuebunny/crossref_metadata_2025 huggingface dataset:
Coating thickness measurement of multilayer ferromagnetic samples based on pulsed eddy current testing technology
Authors: Wen Dongdong , Wang Songlei , Xue Zhigang , Hu Anbin
Published: February 2023

Pulsed eddy current (PEC) technology serves as a popular testing method for multilayer structures and is widely used in coating and substrate thickness measurement. However, in the coating thickness measurement of a multilayer structure, the substrate thickness effect is a disturbance
that needs to be eliminated urgently. In order to reduce the substrate thickness effect, in this paper a twice difference normalisation method is proposed to obtain a signal feature independently of the substrate thickness effect for measuring the coating thickness of a multilayer ferromagnetic
structure. The simulation and experimental results demonstrate that a fitting line of the peak value of twice difference normalisation signals can be obtained by using the twice difference normalisation method when only the coating thickness changes. The normalisation fitting line is immune
to the substrate thickness effect and can be used to measure the coating thickness of a multilayer ferromagnetic structure, which means that the twice difference normalisation method is feasible for high-precision evaluation of the coating thickness of a multilayer ferromagnetic structure
when the substrate thickness changes. This study will improve the coating thickness measurement accuracy of multilayer ferromagnetic structures when the substrate thickness changes in the PEC testing.
Comparison of electrocardiogram diagnostic criteria in diagnosis of left ventricular hypertrophy using 3D echocardiography as standard
Authors: Mathur Rohit , Pawan Sarda  , Anil Baroopal  , Pankaj Kumar  , Abhishek Sakwaria
Published: February 2023

Background: The echocardiogram (ECHO) has a better diagnostic performance for left ventricular hypertrophy (LVH) than the electrocardiogram (ECG), but ECG is most widely used diagnostic method. We aimed to assess the correlation between ECG based diagnosis of LVH with echocardiography-based diagnosis of LVH as standard.
Methods: Patients with evidence of LVH using echocardiographic criteria were included in the study. Patients were subjected to four electrocardiographic criteria to assess the LVH: 1. Sokolow-Lyon criteria; 2. Romhilt and Estes scoring system; 3. Cornell voltage criteria; and 4. Gubner voltage criteria. After assessing the results of ECG and echocardiography diagnostic validity tests (by calculating specificity and sensitivity), the Kappa measure of agreement was performed.
Results: In maximum patients (52.8%) LVH was detected by using ECG LVH Sokolow Lyon criteria, followed by Cornell voltage CR criteria that detected LVH in 38.9% cases. Sokolow Lyon ECG criteria showed high sensitivity while Romhilt and Estes criteria showed maximum 98% specificity in diagnosing LVH. Sokolow Lyon’s ECG criteria was highly sensitive in assessing all co-morbidities, except CKD where it was diagnosed better by using Cornell voltage criteria.
Conclusions: In cases of diagnosing LVH in patients with co-morbidities, ECG LVH Sokolow Lyon CR was found to be the most sensitive criteria except CKD where it was diagnosed better by using Cornell voltage criteria. For assessing the patients for LVH, the role of ECG with all the commonly used criteria is of limited value and ECHO should be the method of choice.
Post treatment outcome and quality of life in patients with inoperable advanced gastric carcinoma
Authors: Major Tariq Hasan  , Gopal Chandra Sarkar  , Mizanur Rahman  , Kaoser Alam  , Mohammad Jahan Shams  , Mahfuzar Rahman  , Suman Kundu
Published: February 2023

Background: The outcome of treatment for advanced gastric carcinoma can vary depending on a number of factors, including the stage and aggressiveness of the cancer, the patient's overall health, and their response to treatment. In general, the prognosis is poor, with a median overall survival of less than one year. Quality of life (QOL) is an important consideration for patients with advanced gastric carcinoma, as they may experience a range of symptoms such as pain, fatigue, and difficulty eating. This study aimed to evaluate the post-treatment outcomes and QOL in patients with inoperable advanced gastric carcinoma after treatment with cisplatin-capecitabine and with oxaliplatin-capecitabine.
Methods: This Quasi-experimental study was conducted at the department of oncology, Bangabandhu Sheikh Mujib medical university, Dhaka, Bangladesh. The study duration was 1 year, from February 2021 to March 2022. During this period, a total of 64 cases of advanced gastric cancer were divided in two equal groups, arm A who had received cisplatin capecitabine, and arm B who received oxaliplatin capecitabine.
Result: The mean age at diagnosis was 55.85 and 56.76 respectively. The majority of the patients, 43.8% in arm A and 50% in arm B, ranged in age from 61 to 70. The gender distribution was similar, 78% and 69% of patients in arm A and B respectively were male. Both groups had the majority of patients receiving an ECOG performance rating of 2, with 68.8% in arm A and 59.4% in arm B, and the liver being the most common metastatic site for 56.3% in arm A and 50.0% in arm B. The most frequent risk factor was Helicobacter pylori infection, observed in 68.8% of arm A and 78.1% of arm B. The most common primary tumor site was the antrum, with 50% and 53.1% patients in arm A and B respectively had the primary tumor in the antrum of the stomach.
Conclusions: In inoperable advanced gastric cancer, the cisplatin-capecitabine regimen is equally effective as oxaliplatin-capecitabine in terms of disease outcome. Furthermore, the cisplatin-capecitabine regimen is less costly than the combination of oxaliplatin-capecitabine, and provides almost similar QOL. As a result, the cisplatin-capecitabine regimen could be utilized as an alternate choice in patients who are unable to afford an oxaliplatin-based regimen.
Myofibroblastoma of the male breast: incidental diagnosis of a rare entity
Authors: Ferreira Nuno V. , Torgal Margarida C. , Pais Jorge M. , Santos Gustavo C. , Gonçalves Inês C. , Cunha Fernanda S. , Amado Cristina M. , Valente Tânia T. , Ferreira Gonçalo S. , Dias Sofia S. , Santos Miguel C.
Published: February 2023

Myofibroblastoma of the breast is a benign tumor originated from mesenquimal cells with a very low incidence in breast pathology. Only 80 cases were reported until 2018. Eight histological patterns were described and may mimic a number of other breast diseases. A 55-years old male was diagnosed with an incidental left breast nodule. An ultrasonography with biopsy showed a 27 mm nodule compatible with myofibroblastoma. We performed a lumpectomy via modified Benelli technique. Surgery was curative and the only necessary treatment. Myofibroblastoma could be misdiagnosed and clinical differential diagnosis includes other benign and malignant breast lesions. In the setting of a diagnosis, histology may be confusing as myofibroblastoma may exhibit a wide spectrum of histological features that defines 8 variants. These subgroups can mimic malignant lesions in their histological pattern. Definitive diagnosis depends on histopathological and immunochemical results. Physicians must be aware about heterogeneity in morphological and immunochemical aspects of myofibroblastoma and his variants, as they can lead to erroneous management of the lesion. Surgery is important for a definitive and accurate diagnosis, excluding malignancy and relieving the burden of a close image-based surveillance.
Assessment of myofascial pain syndrome among married female healthcare workers: a cross sectional comparative study in a tertiary care centre
Authors: George James C. , Babu Subin , Mathew Deny , Raj Rejul K. , Kurian Henry Z. , Abraham Koshy , Joseph Kevin , Eapen Rahul George , Saju George
Published: February 2023

Background: Myofascial pain syndrome (MPS) is common among females between ages 20-40 years. Psychosomatic and mechanical reasons are attributed as causative factors. Female health care workers (FHW) in hospitals with rapid patient turn over are vulnerable to develop MPS. Our aim was to ascertain the prevalence of MPS in married FHW working in various departments of the hospital and its association with poor sleep and work stress.
Methods: We selected married FHWs in 20-50 years age group and divided them into two groups, medical and paramedical (those involved directly and indirectly with patient care respectively). MPS was diagnosed after detailed personal interview and clinical examination. Sleep duration was divided into less than 5 hours and more than 5hours. Presence of work-related stress and other medical parameters were also recorded.
Results: A total of 150 medical and 150 paramedical FHWs were included in the study. Overall prevalence of MPS among FHWs was 42%, of which, medical group was 32% and paramedical was 52%. The paramedical group showed significantly higher prevalence of MPS (p: 0.02). Sleep was less than 5 hours in 29.3% of medical FHW and 13.3% of paramedical. This difference didn’t show any association to MPS (p=0.8). 38% FHW perceived excessive work stress, 40% were paramedical and 36% were medical. This didn’t correlate with prevalence of MPS (p=0.2) among them.
Conclusions: Paramedical FHW experienced more MPS than medical and it was more of mechanical type and not due to work stress or sleep deprivation.
Conceptualization of a Greek Loan-Word of Orthodox Discourse Icon in a Literary Text (on the Material of the Texts of I.S. Shmelyov)
Authors:   Saratov State University, Luchina E. I.
Published: February 2023

The article is focused on the conceptualization of Greek loan-words from the Orthodox discourse in literature. On the material of prose by I. Shmelyov we have analyzed the structure of the concept icon. It is possible to distinguish objective-notional, imagery-symbolic, and evaluative levels of the concept. Their distinctive features are shown to be determined by cultural and religious traditions and also explained by narrative characteristics of the works.
The Principles of Adapting Spoken Informal Discourse into the Written One: Working with the Semantically Devoid Elements
Authors:   Saratov State University, Kokoshkina I. V.
Published: February 2023

The article focuses on the question of working with the semantically devoid elements when adapting spoken discourse into written. The author distinguishes functions with which semantically devoid elements can be endowed in the spoken variant of the memories under research, as well as the reasons of their being preserved in the written text or their elimination in processing. Possible principles were revealed by which an editor is guided upon an encounter with every case of author’s usage of semantically devoid elements.
Specific Features of the Lexico‑semantic Field «Disease» in the Written Form of scientific Medical Discourse
Authors:   Razumovsky Saratov State Medical University, Rodionova T. V.
Published: February 2023

The article is concerned with the problem of investigation of the social‑ professional group discourse from the point of view of semantic fields. It describes the peculiarities of the lexico‑semantic field «Disease» based on the material of the written form of the scientific medical discourse, presents the structural and functional analysis of the field under research.
Interjection Invectives and General Problems of Invectology
Authors:   Saratov State University, Kulakov A. E.
Published: February 2023

The article discusses the general problems of Russian invectol‑ ogy: the concept of «invective», the correlation of the invective and obscene language. A particular attention is paid to the communicative nature of interjection invectives and their functioning in the discourse.
Types of Secondary Speech Genres in Internet Communication
Authors:   Saratov State University, Rogachova N. B.
Published: February 2023

A classification of secondary speech genre based on the analysis of Internet communication genres is presented in the article. The author contrasts diachronic and synchronic types of secondary speech genres, explores the subtypes and the characteristics of their mani‑ festation in Internet communication.
Linguistic Creativity of the Schoolchildren, Revealed in Conditions of the Associative Experiment
Authors:   Saratov State University, Sdobnova A. P.
Published: February 2023

In the article, playing techniques of the schoolchildren’s reactions, the causes and the modes of the design of non-usage words are investigated on the material of the Associative Dictionary of the Schoolchildren of Saratov and the Saratov Region. Such reactions are considered as the manifestation of linguistic creativity of the schoolchildren.
The Problem of National and Other‑National in Modernism and Avant-garde
Authors:   Voronezh State University, Ternova T. A.
Published: February 2023

On the example of the literary activity of the Futurists, Imagists, Zaumniks the peculiarities of modernist and avant-garde solution to the problem of the national are investigated.
A Simultaneous Determination Method for the Analysis of Chloride and Nitrate Ions in Air Samples by PLS1
Authors: KUŞ Çiğdem , ATAŞ Havva , KENAR Adnan , TAŞTEKİN Mustafa
Published: February 2023

This study describes a multi-ion-selective electrode system for the simultaneous determination of nitrate and chloride ions in air samples by using multivariate calibration methods. The measurement system was constituted of two ion-selective electrodes, an Ag/AgCl double-junction reference electrode and a multi-potentiometer. The measurements were performed at pH 5.0 acetic acid/sodium acetate buffer. The obtained data were evaluated by using Partial Least Squares (PLS1). The system was used to analyze the synthetic samples and fume-hood samples in terms of the amount of chloride and nitrate. The percentage recovery values obtained from fume-hood samples were 93.8% ± 3.8 and 102.4% ± 2.5 for chloride and nitrate, respectively. The presented system could be an easy-to-use approach for monitoring the amount of chloride and nitrate species in the scope of occupational health and safety analysis.
Comparative Studies of some Chemical and Micronutrient Contents in three Sprouted Samples of Bambaranut (Vinga subterranean [l] verdc.) Landraces
Authors: MİKA'İL Tasiu Abdulmumin , SULE Mohammed , ALHASSAN Adamu Jubril , IMAM Abdullahi Abdulkadir , MUHAMMAD Yusuf , ISMAİL Sagir , BABAGANA Kamaluddeen , YUNUSA Abdulmumin
Published: February 2023

The research was carried out to evaluate the effect of sprouting on chemical and micronutrient contents of Bambaranut (Vigna subterranea [l] verdc.) grown in Kano, Nigeria. Three landraces of Bambaranut (cream, black and zebra) were used for the study. The proximate and mineral contents were analyzed in accordance with the standard methods of analysis. The result of the proximate analysis showed that the moisture and carbohydrate contents reduced significantly (P<0.05) after sprouting while ash, crude protein, crude fat, and crude fiber significantly increased, there was no significant (P<0.05) difference in moisture, crude fiber, and carbohydrate contents between the landraces. The landraces differ in crude protein and fat contents. The results of minerals analysis shows that the landraces differ significantly in Na, Fe, Ca, K, Mg, and Se. However, the amount of Zn, Mn did not significantly differ between the landraces irrespective of sprouting or not. All the three landraces did not differ (P<0.05) in Cu contents. Sprouting leads to decrease in Na, Fe, K, Zn, Mg and Se and increase in Ca and Mn. This study showed that sprouting improves the nutritional quality of Bambaranut irrespective of the landrace.
Prospects for development of modern supersonic passenger aircraft
Authors: Sidnyaev N.I.
Published: February 2023

The paper presents fundamentals of the passenger aircraft supersonic dynamics. Basic information about design and technical characteristics is given, typical parameters of supersonic passenger aircraft are considered and main issues of their design are highlighted. Images are presented of the promising supersonic aircraft, which have competitive advantages due to the best technical, economic, operational and environmental performance. Key areas in ensuring design and development of the domestic supersonic passenger aircraft (SPA) of the next generation are given including the advanced scientific and technical solutions. It is postulated that acceptable ecological performance of the new generation SPA is necessary due to significant tightening of the national and international requirements to ecological characteristics of the civil aviation aircraft, namely in the context of the problem of minimizing harmful effects of the supersonic passenger aircraft on the environment. Ways are considered to ensure acceptable level of the sonic boom during flight at the supersonic cruising speed, compliance with noise standards in the airport area and in reducing harmful emissions into the atmosphere. All this requires searching for new technical solutions, comprehensive analysis and selection of the most rational options for the SPA airframe aerodynamic scheme and its power plant. Russian and foreign scientific research, design and development works on the supersonic topics were analyzed. Economic efficiency of the civil aviation aircraft operation is considered with the prospect of flying at the supersonic speed. Difficulties in design and development of a supersonic passenger aircraft are noted. Contradictions that arise during design and development are shown. Namely, selection of the correct model for the aviation industry plays an important role and in most cases becomes the basis for taking an approach to solving a particular problem.
Calculation of boost gas parameters at filling the dead-end zones in pneumohydraulic system feed lines of the liquid-propellant rocket engines
Authors: Diesperov N.V. , Polyanskiy A.R. , Sapozhnikov V.B.
Published: February 2023

The paper proposes a mathematical model to estimate boost gas parameters at filling the feeding lines dead-end zones of the pneumohydraulic systems (PHS) of the liquid-propellant rocket engines (LRE). These calculations are required in preliminary assessment of the design characteristics of the PHS feed lines designed to ensure operation of the LRE pneumoautomatic systems. Engineering methodology currently existing to solve this problem provides for solution of a system of ordinary differential equations and does not allow tracking alteration in pressure and temperature along the length of the dead-end zones at filling the PHS feed lines. The proposed model takes into account inhomogeneity of the flow parameters along the length of the dead-end zones, as well as the nonadiabaticity of the flow, i.e. it assumes presence of the heat exchange between the walls of the feeding line and the boost gas. The presented model was used to construct dependences of gas parameters alterations in the feeding line. Results obtained were compared with calculations according to the evaluation method, which is traditionally used in the engineering practice to solve this class of problems.
Conditions and ballistic scheme of a space experiment on wireless transmission of electrical energy
Authors: Evdokimov R.A. , Tugaenko V.Yu. , Smirnov A.V.
Published: February 2023

The paper discusses conditions for conducting sessions of the Pelican space experiment on wireless transmission of electrical energy in the laser channel between the Russian Segment of the International Space Station and the Progress transport cargo spacecraft. Experiment objectives, composition and installation of the Pelican scientific equipment for its implementation are briefly considered. Ballistic schemes that meet requirements for conducting the space experiment, as well as the safety requirements, are proposed. Feasibility of the experiment sessions is shown from the point of view of compliance between parameters of the Progress spacecraft and the Station relative motion and capabilities of the emitter guidance system elements. Characteristic speed expenditures were evaluated with the Progress spacecraft maneuvering to perform repeated passages of the station. The estimates obtained confirm possibility of at least five sessions of the space experiment with one Progress spacecraft.
Multistep terminal guidance algorithm with intelligent adaptation to wind disturbances
Authors: Klishin A.N. , Kolesnikova D.S.
Published: February 2023

The paper presents a qualitatively new approach to terminal guidance at the final trajectory section for the surface-to-surface class aerial vehicles. The proposed structure of the adaptive control system for an aerial vehicle is based on the multi-step terminal guidance algorithm. Adaptive corrections to the control coefficients were calculated using the developed method for identifying the wind disturbances based on the machine learning models. The work describes technique to form an intelligent algorithm for identifying intensity and direction of the wind load acting on the aerial vehicle in flight. Options of the machine learning models used in the guidance system intelligent block were investigated; their operation results are presented; and the comparative analysis has been carried out. The adaptive guidance system operation procedure is demonstrated on a typical model of the aerial vehicle flying in the atmosphere and targeting a fixed object. Numerical simulation results are presented, and possibility of using such an algorithm and implementing the described system are demonstrated.
Habilidades blandas y la web 2.0 en la educación secundaria
Authors: Veytia Bucheli María Guadalupe , Cárdenas Mata Saraí
Published: February 2023

The globalization of society combines technical aspects that come from technology with different skills for the development of an integral education for life, so it is important that the teaching-learning process is oriented not only to the development of hard or technical skills but also of soft skills. The methodology used consisted of a bibliographic review, documents that allowed the discussion to raise the importance of the development of skills from an early age. The contribution is considered from the need to implement strategies to enhance soft skills from web 2. 0, because it is an issue that influences the academic field in a globalized world that will have an impact on the different areas of life for which they must be prepared and provide solutions to the challenges that the XXI century society poses either in the educational, family, social and/or labor area, thus the objective of the work is to know the importance of soft skills from basic education at the secondary level, in the teaching-learning through Web 2.0 tools.
Keywords: Soft skills; hard skills; teens; Web 2.0 tools; technology.
Effect of Zeolite Concentration on Hydrogel Characteristics of Arrowroot-Based Starch-G-Poly(Acrylic Acid)/Zeolite Composite
Authors: Sjaifullah Achmad , Saputra Beny Akhmat , Adiwinata I Nyoman , Santoso Agung Budi , Busroni  , Reza Muhammad
Published: February 2023

This study aims to synthesize a hydrogel zeolite composite of arrowroot starch graft copolymerized with acrylic acid through a radical polymerization reaction in a water. Various scenarios were tested using different natural zeolite concentration to determine the impact on swelling/water absorption of the composite. The resulting product was a solid gel-the test results showed that the swelling increased as the ratio of starch to acrylic acid decreased. Increased starch concentrations generally lead to decreased water absorption (swelling capacity). Adding a zeolite improved swelling to some extent and the optimum zeolite concentration was 60%. The increased concentration of zeolite also hardened the hydrogel composite. The highest swelling in the hydrogel composite of starch-g-poly(acrylic acid)/zeolite 60% is 1056.25 g.g-1. FTIR analysis of functional groups was conducted to determine differences in the IR spectra of arrowroot starch, acrylic acid, hydrogels, zeolites, and composite hydrogel. Si-O signal appearing on the IR spectra of hydrogel composite with wave number 1030 cm-1 indicates that composite hydrogel with zeolite was synthesized
Optimization of Centrifugation Speed and pH in Extraction of Uricase Enzyme from Goat Liver
Authors: Handayani Wuryanti , Esti Utarti  , Riki Juni Krismiadi  , AA. Istri Ratnadewi
Published: February 2023

The human body does not have an enzyme that can break down uric acid, so the accumulation of uric acid can cause disease. This problem can be overcome by uricolytic therapy by utilizing the activity of the uricase enzyme. In this study, the uricase enzyme was extracted from goat liver by optimizing the centrifugation speed and the extraction pH. The purpose of the optimization is to get maximum uricase activity. Uricase extraction to optimize centrifugation speed using borate buffer pH 8.5 then centrifuged at 7.000; 9.000; 11.000; 13.000 and 15.000 rpm with a temperature of 4oC. Furthermore, pH optimization was carried out using pH buffers 6, 7, 8, 9, 10 and 11 by centrifuging the optimum speed obtained. The crude extract obtained was further tested for its enzyme activity . The results showed that the highest uricase activity was achieved if the extraction was carried out at pH 8 using centrifugation at an optimum speed of 13,000 rpm. The higher uricase activity indicates that the extracted uricase concentration is increasing.
Solid State Transformation of TiO2 Rutile and its Photocatalytic Activity
Authors: Sulistiyo Yudi Aris , Kamila Wilda , Andarini Novita , Suwardiyanto Suwardiyanto , Sunnardianto Gagus Ketut , Haryati Tanti
Published: February 2023

Transformation phase TiO2 Rutile was conducted to improve the photocatalytic activity. This study evaluated the transformation phase of TiO2 rutil using solid state rection method and tested for gycerol conversion reaction. a semiconductor material that can be applied for glycerol conversion. The solid state reaction using a mixture of TiO2 Rutile and sodium titanate in mole rasio 1:4 that was heated in 750 oC. XRD analysis evaluated the transformation phase of the solid state reaction product, while band gap energi was calculated following UV-Vis diffuse reflectance data. The photoactivity of glycerol was exposed by UV-Light in various time (5, 10, 15 h) that of the liquid product was analyzed by gas chromatography. Solid state reaction transformed TiO2 rutil to polymorph structure (TiO2 rutile, TiO2 anatase, and sodium titanate Na4O12Ti5). The band gap energy of the product was 3.2 eV. The optimum photocatalytic activity was 62.7% in glycerol concentration 0.25 M for 15 h time reaction.
Identification and determination α and β-acids from Columbus hops using Reverse Phase High Pressure Liquid Chromatography
Authors: Zulfikar Z. , Antje Labes
Published: February 2023

The present study has demonstrated the  HPLC method for identification and determination a and b-acids in Columbus hops. the measurement conditions has been set up included the use of Reverse phase C18 column Chromolith, gradient elution with methanol (A) and Acetonitril acidified with phosphate buffer at pH 2.8. While the flow rate has been applied of 0.8 mL/min, and it is run for 25 minutes. The separation of standard and sample has been monitored using UV variable detector in the rang of 300-340 nm. Pretreatment sample has been done using SPE with the cartridge of C18 similar to the analyte column. The results found that a four predominant peaks for α and β-acids, namely cohumulone (6.6 min), the second peak represents a mixture of humulone and adhumulone (8.9 min),  the third peak is colupulone (15.9 min) and the fourth is  a mixture of lupulone and adlupulone (16.7 min). The quantity of sample has been determined according to multipoint calibration using ICE2 standard, the sample found are 0,209 g/L cohumulone, 1.087 g/L of humulone and adhumulone, 0,349 g/L of Colupulone and 0.630 g/L of mixture of lupulone and adlupulone. In addition it is high precision measurement that is indicated by the value of RSD less than 1%.
Synthesis, Characterization and Antibacterial Activities of Ferrocene Ligands and Their Binuclear Complexes
Authors: Ürgüt Ozan Süleyman , Tavman Aydin , Eser Muazzez Gürgan
Published: February 2023

6-Chloro-2-ferrocenyl-1H-benzimidazole and (E)-((4-chloro-2-hydroxyphenylimino)methyl)ferrocene ligands and their Fe(III), Co(II), Cu(II), Zn(II) and Pd(II) complexes were synthesized. The structure of ligands and metal complexes has been investigated by different methods. In addition, magnetic moment, molar conductivity measurements and antibacterial activity of the ligands and the complexes were investigated.
Preparation of Composites Based on Caffeic Acid and Fumed Silica and Evaluation of Their Antioxidant and Antimicrobial Properties
Authors: Stavinskaya Oksana , Laguta Iryna , Kuzema Pavlo , Skorochod Iryna , Roy Alla , Kurdish Ivan
Published: February 2023

The work was aimed at preparing the CA+A300 composite consisting of caffeic acid (CA) and fumed silica (A300) and at comparing the properties of CA in the solution and in the composite. The results showed that the solution and the composite are effective antioxidant/antimicrobial agents and that inclusion of CA in the CA+A300 composite provides its gradual release into solutions and reaction mixtures, thus ensuring a prolonged action of the compound.
Intestinal malrotation: case description and publication analysis
Authors: Simonov M. V. , Zel'ter P. M. , Solovov D. V. , Sidorov E. A.
Published: February 2023

Intestinal malrotation is a rare congenital anatomical anomaly that results from an abnormal bowel rotation at 10–12 weeks of embryonic development. Clinical manifestations depend on age. In children, intestinal malrotation is manifested by a midgut volvulus (Ladd syndrome). In adults, the presence of intestinal malrotation increases the risk of acute intestinal obstruction. This article presents a case of asymptomatic intestinal malrotation in a 52-year-old female patient.
Identifying a wide range of mutations in the BRAF gene for prescribing targeted drugs for melanoma treatment
Authors: Toropovskiy A. N. , Nikitin A. G. , Solov'ev A. V. , Khuzina R. M. , Pavlova O. N.
Published: February 2023

Melanoma is an aggressive malignancy of the skin and mucosa of neuroepithelial nature, heterogeneous both in phenotype and molecular genetic characteristics, with a high risk of progression and a steadily increasing incidence of about 5% a year. The development of melanoma is due to both external (UV exposure) and internal factors, the main ones being mutations in oncogenes and tumour suppressor genes. Hyperactivation of RAS/RAF/MEK/ERK signalling pathway is observed in 75% of skin melanoma cases, and one of its key factors is serine threonine kinase encoded by BRAF gene. Oncogenic mutations of BRAF mimic the phosphorylation of the activation loop of the protein, which results in BRAF being in a permanently activated state. Subsequent operation of the MAPK signalling pathway in a non-stop mode and loss of BRAF negative feedback leads to uncontrolled cell growth and proliferation. The most common mutations in the BRAF gene are p.V600E (valine replacement for glutamic acid), which accounts for up to 95% of all BRAF-mutant melanomas, and p.V600K (valine replacement for lysine), which can account for up to 20% of cases or more. Development of non-selective and selective inhibitors of mutant BRAF protein make mutation in this gene a predictive marker of response and efficacy of targeted therapy.
Mathematical modeling of the kinetics of multiple ethanol intake
Authors: Nedugov G. V.
Published: February 2023

The aim of the studyis to construct a mathematical model of the kinetics of multiple ethanol intake based on the kinetic equation of zero-order ethanol elimination with absorption and irrevocable first-order absorption deficiency, as well as its implementation in the format of a computer program. Analytical mathematical modeling of the kinetics of multiple oral administration of ethanol is performed on the basis of this kinetic equation. In the course of modeling, a kinetic summation method was developed that allows to perform a mathematical description of the dynamics of ethanol content in the body in the case of repeated intake of alcoholic beverages of any volume and strength, separated by time intervals of any duration. The developed computational algorithm is implemented in the format of the Alcohol Calculator V 3.0 computer program. The conclusion is made about the expediency of using the developed information and computing technology in the forensic assessment of the quantitative alcohol content in the body at a legally relevant time.
Contribuições para a qualidade do ar interior em salas de aula pós pandemia de COVID-19
Authors: Silva Saulo Vieira de Oliveira , Pagel Érica Coelho
Published: February 2023

No final de 2019 surgiu uma nova doença provocada pelo SARS-CoV-2 e, em seguida, foi declarada pandemia pela Organização Mundial de Saúde. Tal fato, implicou em inúmeras restrições, dentre elas, o fechamento de escolas em diversos países. Com o retorno gradual das atividades de ensino, os estabelecimentos se viram obrigados a adotarem protocolos de prevenção. O objetivo deste trabalho foi levantar, na literatura científica, as formas de contaminação de pessoa para pessoa em ambientes interiores, com foco em salas de aula, bem como identificar as diferentes estratégias propostas para redução do risco de infecção dos usuários, sobretudo no que se refere à ventilação e ações para a mitigação da transmissão do vírus em escolas. A metodologia adotada foi a Revisão Sistemática da Literatura (RSL), que partiu de uma seleção de artigos junto aos portais PubMed e Portal de Periódicos da CAPES, resultando na análise de 52 documentos. Como resultados, identificou-se que as partículas aéreas emitidas por indivíduos infectados possuem grande variação de tamanho e alcance, o que diversifica a possibilidade de contágio. Os trabalhos indicaram a necessidade do incremento da ventilação natural por meio da abertura constante de janelas e portas; do aumento das taxas de renovação do ar interno, sem recirculação; do uso de filtros de alta eficiência para eliminação das partículas contaminadas e da necessidade de preocupações que visem ambientes escolares saudáveis, tanto durante situações pandêmicas quanto não pandêmicas. A pandemia reforçou a importância da temática da qualidade do ar de interiores nos estudos de arquitetura e construção.
Comunicação na aula de matemática
Authors: Salgado Maria Aparecida de Jesus , Losano Ana Leticia
Published: February 2023

Tendo origem em uma pesquisa desenvolvida por uma professora-pesquisadora, o artigo apresenta uma revisão sistemática da literatura com foco na comunicação na aula de matemática. O trabalho persegue dois objetivos: 1) Delinear as perspectivas teóricas e metodológicas e os principais resultados das pesquisas na temática; 2) Analisar os sentidos que a revisão de literatura adquire quando é desenvolvida no marco de uma pesquisa do professor. Os resultados apontam a complexidade da transformação da comunicação na aula de matemática e as potencialidades da colaboração e da reflexão para sustentar esses processos. A análise revelou que, na pesquisa do professor, a revisão de literatura permite situar a nova pesquisa no campo de investigação assim como dar importantes subsídios à prática de ensino que será o objeto da pesquisa. Assim, o trabalho contribui a desvendar as potencialidades da pesquisa do professor como forma de construção de conhecimento válido no campo educacional.
Micro-consumerist bollocks in the fight against plastic pollution: when good intentions - and regulatory initiatives - go awry
Authors: da Costa João Pinto
Published: February 2023

Plastic pollution has emerged in recent decades as one of the most pressing issues of environmental concern. However, most of the regulatory and legislative initiatives aimed at curtailing this problem have centered on measures that have very limited impact on the overall prevalence of these materials in all environmental compartments. The minimal influence of these initiatives has been due to their often limited and minor effects on the overall production, use and waste management of plastics. Additionally, the onset of the 2019 global pandemic has resulted in many of these measures being put on hold or cancelled altogether, resulting in increasing levels of plastics in the environment and significantly hampering the combat against plastic pollution. This perspective focuses on microplastics, given their pervasiveness and potential ecological, environmental, and health effects. The sectors and industries contributing the most to this pollution are reviewed and assessed from a societal and environmental perspective. Effective regulatory tools are suggested to help reduce plastic emission levels into the environment.
Assets Value Added and Assets Liquidity on Stock Liquidity
Authors: Pandiangan Roristua , Basri Yuswar Z. , Mayangsari Sekar
Published: February 2023

The purpose of this study is to determine the impact of assets value added and assets liquidity to stock liquidity in the context and evidence in Indonesia and in relatively different situations and conditions. The novelty of this research is in the assets value added using net value-added measurements, the research was conducted in the context and evidence in Indonesia, this research was conducted in two different situations, namely 2018-2019 (before the corona virus occurred) and 2020 (the corona virus occurred). The contribution of this research fills the narrow research gap in the field of stock liquidity from the perspective of assets value added in the context and evidence in Indonesia. The population in this research are entities listed on the Indonesia Stock Exchange with a research sample of entities categorized as manufacturing entities, research year 2018-2020, data analysis methods in this research used multiple regression, moderate regression (MRA). Main Findings: (i) Assets Value Added, Assets Liquidity and Information Asymmetry simultaneously effect Stock Liquidity. (ii) Stock Liquidity is positively impacted by Assets Value Added. (iii) Stock Liquidity is negatively impacted by Assets Liquidity. (iv) Information asymmetry weakens the impact of Assets Value Added to Stock Liquidity. (v) Information asymmetry strengthens the impact of Assets Liquidity to Stock Liquidity. The results of this study provide evidence in favor of information asymmetry theory and signal theory.
The plant collections of James Franklin Maxwell from Thailand
Authors:   Naturalis Biodiversity Center, Research Group Tropical Botany, P.O. Box 9517, 2300 RA Leiden, The Netherlands, van Welzen Peter Cornelis
Published: February 2023

James Franklin Maxwell ranks among the best collectors of Thai plants. His specimens are all high quality, rich in flowers and/or fruits and carefully prepared with many duplicates and mostly with labels that contain much information. The total number of collections can only be estimated but likely exceeds 32,000. An overview is provided of the evolution in the labels, from simple to the complex ones produced during Maxwell’s third stay in Thailand, covering his work while at Prince of Songkhla University and Chiang Mai University. Problems with the labels are discussed, that are partly due to the use of a typewriter and carbon paper, partly caused by his phonetic way of dealing with the Thai language, and sometimes also by the high information content with regards to habitat/vegetation types and the colour patterns of the plants.
Strategic Partnership of Romanian and Moldavian Political Parties in the New Political Realities
Authors: Velikaya N. , Tatarov R.
Published: February 2023

The article examines the features and main directions of interaction between political parties of the Republic of Romania and the Republic of Moldova from the early 1990s to the present day. Analyzing the historical prerequisites for stable ties between political parties of the two countries, the authors draw attention to the fact that they are based on the shared ideas of unionism and formation of a single political and cultural space between Romania and Moldova. The authors also examine conditions for close cooperation between the parties such as Moldova’s choice of the European path of development, strengthening strategic partnership with Romania and the EU countries and ensuring security in the region. This research demonstrates that the high degree of Romania’s involvement in the Moldovan political processes creates special conditions for inter-party interaction, which covers different spheres of real politics. Considering political parties as important actors in the communication process that can influence political decisionmaking, the authors identify several areas of cooperation, including educational projects, youth initiatives, inter-party dialogue at various levels, activities of representative offices of Romanian parties on the territory of the Republic of Moldova, inclusion of Moldovan politicians in the electoral process in Romania. As a result, the research categorizes political parties of Moldova and Romania on the basis of their attitude to the ideas of unionism and main ideological priorities, into three groups. The authors emphasize that in the context of the Russian-Ukrainian conflict, the agenda of cooperation between Chisinau and Bucharest is reduced to the points of Romania supporting Moldova’s European path and the latter ensuring its own security and sovereignty. Under these circumstances, cooperation between political stakeholders of the two states is intensifying. This kind of interaction mainly covers the right flank of Moldovan parties. The multidimensional nature of political interdependence between the two sides of the Prut demonstrates the high degree of mutual involvement of parties of the two states in each other’s internal affairs. The basic principle in political programs of Romanian and Moldovan parties is the idea of Uniri. This idea of building a single state has become the leitmotif of establishing communication channels between the main actors of the political process in Romania and Moldova, who are committed to a common European future.
La colonización del ‘más allá’: el mito mostoleño en la geografía moral de Madrid = The colonization of ‘beyond’. The myth of Móstoles in the moral geography of Madrid
Authors: Coppari Alessandra , Blázquez Víctor
Published: February 2023

ResumenA partir de los años 80 del siglo pasado Móstoles empezó a ser llamado el ‘más allá’, en un contexto de transformación urbanística que expresaba la lucha por la definición de las fronteras de Madrid. En ese contexto se establecían relaciones de dominación centro-periferia propias de un discurso basado en la compartimentación territorial de la ciudad. Así, las nuevas áreas colonizadas por la ciudad quedaban bajo la centralidad de su determinación moral. En este trabajo tratamos de mostrar, a través del mito —ofetiche— mostoleño del ‘más allá’, cómo el desarrollo colonizador de lo urbanoexpande el conflicto moral entre el centro y la periferia; entre el ‘acá’ y el ‘más allá’. Tras plantear el significado del mito en relación con la pluralidad inherente a su significación, analizamos discursos procedentes de distintos ámbitos sobre la toponimia del ‘más allá’ madrileño: desde la mitificación histórica del 2 de mayo de 1808 hasta las recientes expresiones artísticas que reclaman el valor periférico de Móstoles, pasando por los planes urbanísticos que definieron la ubicación territorial y moral de este mito urbano. Con ello, tratamos de mostrar cómo el conflicto moral entre el centro y la periferia anula el conflicto político inherente a la ciudad.AbstractFrom the 1980s onwards, Móstoles began to be called the 'beyond', in a context of urban transformation that expressed the struggle for the definition of Madrid's borders. In this context, relations of centre-periphery domination were established in a discourse based on the territorial compartmentalisation of the city. Thus, the new areas colonised by the city were placed at the centre of its moral determination. In this paper we try to show, through the Mostolean myth— or fetish— of the 'beyond', how the colonising development of the urban expands the moral conflict between the centre and the periphery; between the 'here' and the 'beyond'. After considering the meaning of myth in relation to the plurality inherent in its significance, we analyse discourses from different spheres on the toponymy of the 'beyond' in Madrid: from the historical mythification of 2 May 1808 to recent artistic expressions that claim the peripheral value of Móstoles, and including the urban plans that defined the territorial and moral location of this urban myth. In doing so, we try to show how the moral conflict between the centre and the periphery overrides the political conflict inherent to the city.
GNH Community Vitality: Study of Growing Vegetables in Tabjee Village, Darla Geog, Chukha, Dzongkhag, Bhutan
Authors:   BBA, VII Finance B, GCBS, Chukha, Bhutan, Tshewang Karma , Chezom Tashi ,   BBA, VII Accounting, GCBS, Chukha, Bhutan, Wangchuk Khandu ,   BBA, VII Finance B, GCBS, Chukha, Bhutan, Wangmo Kelzang ,   BBA, VII Accounting, GCBS, Chukha, Bhutan
Published: February 2023

Basic conceptual on the community vitality, we have done research study on the local vegetable supply. Community vitality project that the institutes, colleges, schools under the ministry of education can move forward. It is our ongoing process that we are taking towards by the Colleges under the royal university of Bhutan can empower the villages within the vicinity of the colleges to carry on the contract farming or encourage the village cooperatives to commercialize the organic vegetable production. The colleges under the RUB, all have boarding (mess) as well as self catering facilities. The present model in the supply of the vegetables in the student mess is mostly done involving the local vendors. The vendors in return further outsource to the neighboring states of India for the supply of the vegetables.
Chromosomal Instability in Genome Evolution: From Cancer to Macroevolution
Authors: Comaills Valentine , Castellano-Pozo Maikel
Published: February 2023

The integrity of the genome is crucial for the survival of all living organisms. However, genomes need to adapt to survive certain pressures and for this propose use several mechanisms to diversify. Chromosomal instability (CIN) is one of the main mechanism leading to the creation of genomic heterogeneity by altering the number of chromosomes as well as changing their structures. In this review we will discuss the different chromosomal patterns and changes observed in speciation, in evolutional biology as well as during tumor progression. By nature, human genome shows induction of diversity during gametogenesis but as well during tumorigenesis that can conclude in drastic changes such as whole genome doubling to more discrete changes as indels as well as the recent discovered complex chromosomal rearrangement chromothripsis. More importantly, changes observed during speciation are strikingly similar to the genomic evolution observed during tumor progression and resistance to therapy. The different origins of CIN will be treated as the importance of double strand breaks (DSB) or the consequences of micronuclei. We will also explain the mechanisms behind the controlled DSBs and recombination of homologous chromosomes observed during meiosis, to explain how errors lead to similar pattern observed during tumorigenesis. Then, we will also list several diseases associated to CIN resulting in fertility issue, miscarriage, genetic rare diseases and cancer. Understanding better chromosomal instability as a whole is primordial for the understanding of mechanisms leading to tumor progression.