bluuebunny/crossref_metadata_2025 huggingface dataset:
Effective nano Cyclodextrin-TKIs drug delivery for cancer therapy
Authors: Dastjerdi M.
Published: February 2023

Nanotechnology-based studies pursuing the innovative cancer treatment methods, particularly using drug delivery systems, have significantly increased over the past few years. Some of the impacts of using such systems include the increased cytotoxic activity of drugs, reduced unwanted side effects, and a more stable and controlled release of drugs. Particularly using the targeted delivery systems with helping novel nanocarriers made it possible to kill cancer cells specifically. Meanwhile, Cyclodextrins were known as natural cyclic oligosaccharides which serve the intended purposes. Many cancer researchers were interested in them due to the multiple advantages of a variety of materials utilized as nanocarriers for medication delivery. Regarding their unique structure, they can benefit hydrophobic and hydrophilic drugs. On the other hand, tyrosine kinase inhibitors, with their properties to inhibit the growth of cancer cells, are the valuable drugs of choice for various types of cancer. In this regard, cyclodextrins were used as nano-drug delivery systems to transport tyrosine kinase inhibitors in recent studies by researchers. In this review, some recent medical applications of cyclodextrin-based nanocarriers for the delivery of tyrosine kinase inhibitors and the synthesis methods of cyclodextrin-based compounds have been discussed, and the advantages and disadvantages of using cyclodextrin along with tyrosine kinase inhibitors in the treatment of various cancers were mentioned.
Assessing the Local Tourism Infrastructure and Services towards Tourism Development of San Jose
Authors: Abundabar Ariane Pesimo , Pongpong Marilou A.
Published: February 2023

Local tourism planning and development is a complex area of concern. Many local destinations initiate tourism programs to achieve economic, social, and environmental sustainability. Thus, the local government must explore either its potential natural resource or its potential human resource, including the tourism sector towards development. This study focused on assessing the local tourism infrastructure and services for tourism development in San Jose, Camarines Sur.  The study employed the Community-Based Participatory Action Research (CBPAR) and Exploratory-Descriptive Research Methods (EDRM). These methods involved local stakeholders in assessing infrastructure and services through public meetings, workshops, and individual consultations. The conducted assessments aided the identification of the significant impacts and opportunities in the study area. The study revealed that though the primary services are present in the area, specific issues and challenges must be addressed to improve these services and cater to visitor needs. Thus, the identified problems and challenges on infrastructure must be addressed since the infrastructure is essential for tourism initiatives to prosper.
Commentary: Enhancing Aid Effectiveness: Harmonization, Alignment, Results and Mutual Accountability
Authors: Mazid Muhammad Abdul
Published: February 2023

Representatives of the 23 DAC members, Multilateral Development Banks (MDB), institutions, and 15 partner countries, under OECD/DAC arrangements, affirmed the importance of development to the world’s well-being. The High-Level Forum on Harmonization in Rome 2004 prescribed plans for applying good practice principles at the country level and defined sets of harmonized policies and procedures while aligning aid delivery. The Paris Declaration of 2005 agreed that aid effectiveness must strengthen governance and improve development performance, assist partner countries in developing their systems and institutions so that they can utilize all their resources more efficiently for the benefit of their people, while making partners accountable to each other to tighten the link between aid and ensuring the downward accountability of both partner governments and donors to citizens. Donors should make sure that their development aid fits with the priorities and strategies for development set out by the partner country.
Pengaruh Transfer Pricing, Karakter Eksekutif, dan Koneksi Politik Terhadap Tax Avoidance
Authors: Haztania Santi , Lestari Tri Utami
Published: February 2023

Tax is the largest contribution to the state made by taxpayers and is used as a state necessity for the prosperity of the people. For companies, tax is a profit deduction element which can be a factor that can harm the company. The difference in interests can lead to conflicts such as taxpayer non-compliance which will have an impact on the company's efforts to minimize taxes. This effort is carried out by carrying out a tax avoidance scheme, one of the tax avoidance efforts that is often carried out legally and safely is tax avoidance. Tax avoidance is a legal tax avoidance effort carried out by utilizing the loopholes (gray area) in the applicable tax laws and regulations with the aim of minimizing the amount of tax payable. The measurement of tax avoidance in this study is using the Cash Effective Taxes Rate (CETR) proxy. This study was conducted to analyze the effect of transfer pricing, executive character, and political connections on tax avoidance simultaneously and partially in manufacturing sector companies listed on the Indonesia Stock Exchange (IDX) in 2018-2020. The population in this study is manufacturing sector companies listed on the Indonesia Stock Exchange (IDX) in 2018-2020. The sample selection technique used was purposive sampling. The sample obtained was 35 companies, so the number of observations in this study for 3 (three) years was 105 observation data. The data analysis method in this study was analyzed using descriptive statistics and panel data regression with the help of EViews 10 software. The results of this study indicate that simultaneously transfer pricing, executive character, and political connections affect tax avoidance. Partially, transfer pricing has no effect on tax avoidance, while executive character and political connections affect tax avoidance.
Pengaruh Atraksi Wisata, Citra Destinasi dan Aksesibilitas, Terhadap Minat Berkunjung Wisatawan di Objek Wisata Gunung Dago, Bogor
Authors: Pradana Triandi , Stefanus Purba Antony
Published: February 2023

Dago Mountain is located in Dago Village, Cikuda Wanaherang, Parung Panjang, Bogor, West Java. This tourist attractions is arguably still quite new in the city of Bogor, because it was launch around 2019. The natural tourism area of Mount Dago is located on land that responsible to PT. Perhutani. Then it was handed over to the residents to be managed through “Lembaga Masyarakat Desa dan Hutan” (LMDH). This study aims to find out how the influence of attraction, destination image and accessibility influences the interest in visiting tourists with a total of 90 respondents. The analysis in this study uses the Multiple Linear Regression method and it is obtained that partially the Attraction variable has a significant effect on Interest in attending as evidenced by the Sig value. 0.225 > 0.05 and t count 2.964  0.05 and the t-count value of 2.996 <t-table 1.987. Then the Accessibility variable shows a significant influence on Interest in Visiting, as evidenced by the value of Sig.0.05 = 0.05 and the t-count value of 6.376 <t-table 1.987
Editorial - The NHS urgent and emergency care crisis: how much worse could it get?
Authors:   Editor-in-Chief, Consultant in Acute Medicine, Manchester University Foundation Trust and The Christie, Cooksley Tim
Published: February 2023

NHS urgent and emergency care is under intolerable strain. This strain is increasingly causing harm to patients. Timely and high-quality patient care is often not being delivered due to overcrowding driven by workforce and capacity constraints. This drives low staff morale perpetuating burn out and high absence levels which currently dominate. Whilst COVID19 has accentuated and arguably expedited the crisis; the spiral of decline in urgent and emergency care has been decade long and unless urgent action is taken, we may not yet have reached its nadir.
Patient Characteristics and Variables Influencing Acute Medical Flow
Authors:   School of Medicine, Cardiff University, UK, CF14 4YS, H Wood Callum , Underwood Jonathan ,   Department of Infectious Diseases, Cardiff and Vale University Health Board,   Division of Infection and Immunity, Cardiff University, Davies Craig ,   Acute Medicine Service Manager, Cardiff and Vale University Healthy Board, N Taylor Peter ,   Thyroid Research Group, Institute of Molecular & Experimental Medicine, Cardiff University School of Medicine, Cardiff, CF14 4YS
Published: February 2023

Waiting times are the most widely used indicator of patient flow. This project aims to analyse 24-hour variation in referrals and waiting times for patients referred to the Acute Medical Service (AMS). A retrospective cohort study was conducted at the AMS of Wales’ largest hospital. Collected data included patient characteristics, referral times, waiting times and adherence to Clinical Quality Indicators (CQIs). Peak referral times were found between 11:00-19:00. Peak waiting times occurred between 17:00–01:00, which was longer on weekdays in comparison to weekends. Referrals between 17:00-21:00 had the longest waiting times with > 40% of patients failing both junior and senior CQIs. Mean and median age and NEWS were higher between 17:00-09:00. Weekday evening and nights are problematic for acute medical patient flow. Interventions, including workforce, should be targeted towards these findings.
Blood Culture and Troponin Testing in Suspected Bacteraemic Admissions - Example of Risk Stratification Based on Clinical Testing
Authors:   MD, Department of Internal Medicine, St James’s Hospital, Dublin 8, Ireland, Conway Richard , Byrne Declan ,   MD, PhD, Department of Internal Medicine, St James’s Hospital, Dublin 8, Ireland, O’Riordan Deirdre ,   MD, Department of Internal Medicine, St James’s Hospital, Dublin 8, Ireland, Silke Bernard ,   MD DSc, Department of Internal Medicine, St James’s Hospital, Dublin 8, Ireland
Published: February 2023

Aim: To investigate the clinical predictive value of troponin (hscTnT) and blood culture testing. Methods: We examined all medical admissions from 2011-2020. Prediction of 30-day in-hospital mortality, dependent on blood culture and hscTnT requests/results, was evaluated using multiple variable logistic regression. Length of stay was related to utilization of procedures/services with truncated Poisson regression. Results: There were 77,566 admissions in 42,325 patients. With both blood cultures and hscTnT requested, 30-day in-hospital mortality increased to 20.9% (95%CI: 19.7, 22.1) vs 8.9% (95%CI: 8.5, 9.4) for blood cultures alone and 2.3% (95%CI: 2.2, 2.4) with neither. Blood culture 3.93 (95%CI: 3.50, 4.42) or hsTnT requests 4.58 (95%CI: 4.10, 5.14) were prognostic. Conclusion: Blood culture and hscTnT requests and results predict worse outcomes.
Clinical decision making in acute medicine
Authors:   Clinical Reader, Centre for Medical Education, Queen’s University, Belfast and Consultant in Acute Medicine, Royal Victoria Hospital, Belfast, Trimble Michael , Hennessy Kamran ,   Academic Foundation Programme Doctor, Centre for Medical Education, Queen’s University, Belfast
Published: February 2023

Clinical decision-making is a core skill for the practice of medicine and yet during training there is often little formal analysis of the process of clinical reasoning or instruction about how to do it better. This paper reviews the process of clinical decision-making with a particular focus on diagnostic reasoning. Aspects of psychology and philosophy are applied to the process along with consideration of potential sources of error and the steps that can be taken to minimize this.
Can we improve patients’ physical activity levels after discharge by interventions on the Acute Medical Unit? The ‘teachable moment’
Authors:   MBBS MSc SEM, (University of Nottingham), Murphy JNF , Le Jeune I ,   BM BCh, MA (Oxon), MRCP, PhD (University of Nottingham)
Published: February 2023

Introduction: >30% of the population does less physical activity (PA) than recommended and few patients receive PA advice during a hospital admission (2,5). This study aimed to assess the feasibility of recruiting acute medical unit (AMU) in-patients and to examine the effect of delivering PA interventions to them. Methods: In-patients who were inactive (<150mins/wk) were randomised to either a motivational interview (Long Interview, LI) or brief advice (Short Interview, SI). Participants’ physical activity levels were assessed at baseline and at two follow-up consultations. Results: 77 participants were recruited. At 12 weeks 22/39(56.4%) participants were physically active following the LI and 15/38(39.5%) following the SI. Discussion: Recruitment and retention of patients on the AMU was straightforward. PA advice helped a high proportion of participants become physically active.
Theme of Identity: A Study of Andrea Levy’s The Long Song
Authors: Shamsul Haq Thoker
Published: February 2023

The Long Song (2010) is a contemporary Caribbean neo-slave narrative written by Andrea Levy.  The novel revisits the period of slavery in the early nineteenth century Jamaica depicting the experiences of a slave girl, July at Amity - a sugarcane plantation in Jamaica.  Written in the background of a famous Jamaican slave rebellion, the Baptist War erupted in 1831, the abolition of slavery in 1833 and its aftermath, the novel details the life of the slaves on Jamaican plantations before and after the period of emancipation. Replete with the theme of identity, the novel explores the ethnic and cultural backgrounds of the characters on the plantations where the British class system is largely in vogue. Thus, the paper shall explore the identity of the slaves in the Caribbean which is greatly affected by the British social hierarchy. It shall also focus on how the British class system begins to lose its potential and importance in Jamaica after the Baptist War.
Presentation of the Sufferings of Dalits (Untouchables) in Arundhati Roy's The God Of Small Things
Authors: Dr Rajesh S Latane
Published: February 2023

The present study is an attempt of presenting the sufferings of dalits and their pathetic condition due to their lower caste that figure in Arundhati Roy’s The God of Small Things.  Untouchability and slavery symbolize the deprivation, disgrace, and inhuman oppression on a section of human beings. Men become hostile against one another. Social, political, economic, racial and cultural prejudices are seen at many places. All human beings are born equal but there discrimination among them is created by people with vested interests. The need to define the social, moral and ideological perspectives leads to concern the social dilemma of the underprivileged and exploited in society. Roy’s The God of Small Things is published after Independence. The God of Small Things (1996) is her first novel. The novel is a set in Kerala. The story is simple. It articulates the dalit Christen voice. Overall the novel is psychological presentation and observation of very small things of life. The novel deals with the problem of untouchability and social harassment. It is about the class and caste issues in southern India. Upper caste Christianity is presented in the novel in connection with socio-political changes.Dalits, Untouchability, Inhuman Oppression, Cultural Prejudices, Ideological Perspectives, Underprivileged, Social Harassment, Upper Caste Christianity, Socio-Political
National Politics in the Fiction of Rohinton Mistry
Authors: Ram Autar
Published: February 2023

Representation of contemporary politics and human problems is a major theme for contemporary litterateurs and social thinkers. A number of prolific and eminent novelists such as Rohinton Mistry, Salman Rushdie, Vikram Seth, Khushwant Singh, Nayantara Sahgal, Shashi Tharoor, Amitav Ghosh, Arundhti Roy, Kiran Desai and many more have tried to explore the hidden truth and treacherous activities carried out over Indian citizens by their elected political representative on the name of different government schemes. Rohinton Mistry, an Indian of Parsi in origin presently living in Canada, represented contemporary Indian politics in his novels by subverting the conscious or unconscious cultural categorisations associated with the forms of novels focussing on the human condition located in time and space. He tried to show us how politics is used by politicians of all parties to remain in power for fulfilling their vested interest. Present paper is an effort to describe and discuss how political upheavals have an impact on the psyche of common man. It would discuss the theme of politics in the fiction of Rohinton Mistry.
The Portrayal of Girl Child in Ruskin Bond’s The Blue Umbrella
Authors: Mamta Singh
Published: February 2023

Ruskin Bond, Indian author of British decent, was born on 19 May 1935 at Kasauli, Himachal Pradesh. He was raised at Jamnagar (Gujarat), Shimla and Dehradun. He is a well-known Indian writer in English. He has written more than hundred short stories, six novels, three collection of verse and over thirty books for children. He is considered to be an icon among Indian writers and children’s author and a top novelist. He received Sahitya Academy award for his book; Our Trees Still Grow at Dehra in 1992, and was honored with Padam Shree in 1999 for his lifetime contribution to Indian literature in English. He was awarded with Padam Bhusham in 2014. He has been writing for the last fifty years in different genre of literature. His stories and novels got wide publicity worldwide in India. Various directors produced films on his novels. He was also appreciated by various prizes and awards at national level. In 2005, the Bollywood director Vishal Bhardwaj made a film based on his popular novel for children, The Blue Umbrella. The movie won the National Award for best Children’s film. It is a fine specimen published in 1992. This novella has also been filmed in 2007. It is set in a small village of Garhwal, where a little highland girl, Binya lives. She trades her lucky leopard claw pendent with a picknicker lady for a pretty blue umbrella.
Novels of Shashi Deshpande: A Study with Humanistic Perspectives
Authors: Dr. Vidyakant Shukla  , Dr.  L.U.B. Pandey
Published: February 2023

The crux of novels of Shashi Despande lies in the fact that, it’s not easy to sustain and survive as a woman with dignity in the patriarchal and tradition bound society. The venture may land them into tremendously disastrous situation. At the same time, the message communicated by Deshpande is loud and clear that they will not lie low suffering the pangs of their situation meekly. The protagonists would wage a war against the hostile human condition in which they are found trapped as if it were a cage. In this respect her writings are akin to the vision of Anita Desai unlike that of Arundhati Roy, Shobha De and Manju Kanpur. Despande and Anita Desai evolve a balance between traditional demands and circumstantial compulsions and renegotiate their will to transcend the facticity they are plagued with.
Aspects of Ecology in the Select Literary works of American Beats: An Investigation
Authors: Alok Chandra
Published: February 2023

The literary products of the Beats reflect the companionship between humans and animals. Beat novelists and poets project the elements of compassion for the species and the inanimate things through their eco-sensible prose and poetry Gary Snyder, Jack Kerouac, Allen Ginsberg and Ferlinghetti are very famous literary figures of the Beat Generation. All of these Beats have raised their protest against the war and the social industrialization or establishment which was seen in America and in the other parts of the world. Beats have full appreciation for the oriental countries and their love is manifested in their novels and poems. Beat writers have given a new shape to their literary works by the inclusion of the views and ideas which pertain to spirituality and religion; they posit their faith in the religious function of literature for achieving social and environmental harmony. Beats incorporate visions and dreams in their works and establish themselves as the seekers of reality and truth. This paper attempts to explore Gary Snyder, Jack Kerouac and Ferlinghetti’s ecological consciousness through their select works and also how and in what sense they highlight the grave issues of the global ecology and provide the humanity the solutions in this regard.
Comparison of Calcium Hydroxidea and Triple Antibiotic Paste on Inter-Appointment Endodontic Pain
Authors: Muneer Maliha , Choudhry Maheen , Waris Sunnaeyah , Iqbal SairaMuhammad Pervaiz , Shahid Amira , Noureen Faiza
Published: February 2023

Background: Endodontic pain is related to inflammatory reactions in the tissues correlated to the damage, and the nature of damage. Inter-appointment pain is correlated to the instrumentation, irrigation and all the other procedures done during appointments. Triple antibiotic paste can be more effective intacanal medicament than calcium hydroxide. But there was a need to confirm its effectiveness. Aim: To compare the effect of calcium hydroxide and triple antibiotic on inter-appointment endodontic pain. Methods: This randomized controlled trial was conducted in the Department of Operative Dentistry, PMC Dental Institute, Faisalabad Medical University, Faisalabad for four months. Sixty cases were enrolled by using Non-probability, consecutive sampling and were divided randomly in two groups. In group 1, triple antibiotic paste was placed for inter-appointment pain. In group 2, calcium hydroxide was placed. After one week, pain was observed. Data was analyzed in SPSS 25. Results: In patients who received triple antibiotics paste, the mean age of patients was 36.90±9.49 years. In patients who received calcium hydroxide, the mean age of patients was 34.83±10.32 years. In patients who received triple antibiotics paste, there were 15(50%) males and 15(50%) females. In patients who received calcium hydroxide, there were 16(53.3%) males and 14 (48.7%) females. In patients who received triple antibiotics paste, the mean pain score was 0.90±1.88. In patients who received calcium hydroxide, the mean pain score was 2.83 ± 3.07. In patients who received triple antibiotics paste, there were 6 (20%) patients who had pain while 24(80%) patients did not report about pain. In patients who received calcium hydroxide, there were 15 (50%) patients who had pain while 15(50%) patients did not report about pain. Conclusion: Triple antibiotic paste was found to be more effective in relieving pain than calcium hydroxide. Key words: Calcium hydroxide, triple antibiotic paste, inter-appointment endodontic pain, visual analogue scale
Comparison of Dacron Band versus Segmental Annuloplastyin Treatment of Tricuspid Valve Repair
Authors: Hassan Asif , Gul Saira , Riaz Wasim , Aziz Shahnoor , Ali Bahar , Ejaz Farhan
Published: February 2023

Objective: The objective of this study was to compare outcome of Dacron Band versus Segmental Annuloplasty in treatment of TV repair. Study Design: This was a randomized controlled trial. Place and Duration: This study was conducted at the Cardiac surgery Department, PIC, Jail Road, Lahore from 25 October 2021 to 25 Oct, 2022. Methodology:A total of 148 patients were enrolled in this study and divided into two groups equally. For categorical data like gender, and grades of Tricuspid regurgitation, frequency and percentages was used. For quantitative data mean ± S.D was computed. P-value ≤ 0.05 was taken as significant. Results: The mean age of the cases in Group-A was 47.97 ± 8.29 and in Group-B was 51.01 ± 7.78. In our study post-operative RVEDD and TVPG found significant with p-value 0.044 and <0.01 respectively. Similarly, the p-value of follow-up RVSTDI and RVEDD was statistically significant with p-value 0.03 and 0.007 respectively. Conclusion: Both Dacron band and segmental annuloplasty techniques are available for TV repair; however, dacron band placement in TV repair patients is associated with better RV remodelling, and as a result, a more likely improvement in right ventricular function and a better repair outcome are predicted. After tricuspid valve surgery, dacron band implantation is correlated with a lower incidence of TR recurrence and enhanced long-term event-free survival. As a result, this method in tricuspid valve surgery should be used more frequently. Keywords: Segmental Annuloplasty, Dacron Band, TR, TV repair
To Compare Early Outcomes of Warm Verses Cold Blood Cardioplegia in Patients Undergoing Elective Coronary Artery Bypass Graft Surgery (CABG)
Authors: Bashir Goher , Farogh Ajwad , Khan Muhammad Irfan , Hassan Asma , Ahmad Naseem
Published: February 2023

Objective: To compare the effects of warm versus cold blood cardioplegia on the myocardium of patients undergoing elective Coronary Artery Bypass Graft (CABG) surgery. Study Design: The study was the Prospective Observational study. Place and Duration of Study: At the Punjab Institute of Cardiology in Bahawalpur, Pakistan, 100 patients with ischemic heart disease was scheduled for open-heart surgery. Methodology: From the 25th of October 2021 to the 25th of October 2022, this prospective observational study was carried out in the Cardiac surgery Department of the PIC in Bahawalpur. One hundred patients participated in this research project overall. The means and standard deviations of the continuous variables were reported, while the frequencies of the categorical variables were given in percentage. SPSS 24 version was utilized for the statistical analysis. The All P values <0.05 were considered statistically significant Results: Our results showed that out of 100 patients the mean age of the cases in Group-A was 57.12±3.9 and in Group-B was 55.45±2.6 with insignificant p-value. The findings of current study showed that the male 41(82.0%) and female 9(18.0%) patients in Group-A while male 38(76.0%) and female 12(24.0%) in Group-B with p-value 0.659. Clinical characteristics i.e. The hypertensive 39(78.0%) in Group A while 35(70.0%) in Group B with significant p-value 0.017. Similarly hyperlipdemia in Group A as 11(22.0%) compared with 15(30.0%) with 0.069. Renal failure patients in Group A was 4(08.0%) while in Group B 3(06.0%) observed with p-value 0.032. The clinical characteristics i.e. (CPB time, cross clamp time, cardioplegia dose, number of grafts and complete revascularization) were statistically significantly as p-value < 0.05. Conclusion: According to the available data, the surgeon can make the call between warm and cold cardioplegia when it comes to patient safety. Keywords: CK-MB, CPB, CABG.
A Case Study in Upper Body Kinematics of an Elite Axe Thrower Using Sensor Technology
Authors: Evans Stuart , Bini Rodrigo
Published: February 2023

Introduction: This field-based case study assessed linear accelerations of the scapula and elbow in an elite axe thrower in three different axe throwing techniques using two wearable sensors.
Methods: One elite axe thrower (35 years; height 181 cm; weight 92 kg) participated in this case study. One wearable sensor (an accelerometer) was located on the dorsal surface of the upper thorax between the medial borders of the scapula. An additional sensor was located on the medial epicondyle of the right elbow to capture linear acceleration magnitudes. The participant performed three different throwing techniques, namely a one hand underarm throw, a two-handed overhead throw, and a one hand overarm throw for a total of four repetitions.
Results: Significant differences in scapula acceleration magnitudes were detected in the three throwing techniques analyzed along with significant differences in all acceleration channels (p < 0.001). In contrast, no significant differences in triaxial acceleration magnitude were observed in the elbow in all throwing techniques (p > 0.50).
Conclusions: Magnitudes of scapular acceleration varied significantly depending on the type of throw. In contrast, acceleration magnitudes at the elbow displayed high variability despite a non-significant outcome. A wearable sensor could be a valuable tool to enhance throwing performance.
REMOVING OF THYMOL BLUE FROM AQUEOUS SOLUTIONS BY POMEGRANATE PEEL.
Authors: Hasan Hamad. M. Idres. , Moftah Alfutisi Hanan Mohammed
Published: February 2023

In this study the pomegranate peel were used to removal of thymol blue from its aqueous solutions, after activation at 500 ºC. Different concentrations of thymol blue used. Different parameters were applied including (effect of dose, effect of adsorption time, effect of pH value).The extent of dye removal increased with increase contact time. An acidic pH is suitable for increased adsorption of dye. The Langmuir   isotherm was calculated at the optimum conditions. According to Langmuir isotherm, the mono layer saturation capacity (qm) is 5.28 mg/g.   The study concluded that the activated pomegranate peel gone fruitful adsorption results to removal of  thymol blue and it could be  recommended to using it in other studies of adsorption
The effect of deep tissue massage application on post cesarean women’s pain and anxiety
Authors: Dawoud Salwa El Saied Mahmoud , Atwa Azza Mohamed El-Sayed , Saber Nahed Mousa
Published: February 2023

Background: The most frequent post-cesarean consequences include pain and anxiety which is uncomfortable for women and has increased the use of natural remedies such as deep tissue massage. Aim: To investigate the effect of deep tissue massage on post-cesarean women's pain and anxiety. Design: A quasi-experimental design was utilized to accomplish this study. Setting: The study was conducted at the postpartum department at Sohag University Hospital. Subjects: Included 100 post-cesarean women of a convenient sample assigned into two equal groups study and control) were enrolled in the previously selected setting. Tools: I: Demographic and obstetric assessment sheet, II: Visual Analogue Scale, and III: State-Trait Anxiety Inventory. Results: a highly statistically significant difference was found in post-cesarean women's pain and anxiety between the two groups p<0.01. Conclusion: Deep tissue massage application has a vital role in reducing post-cesarean women's pain and anxiety. Recommendations: Deep tissue massage is recommended to be applied for post-cesarean women to reduce post-cesarean pain and anxiety.
Reclaiming the technology of higher education for teaching digital writing in a post—pandemic world
Authors: Johinke Rebecca , Cummings Robert , Di Lauro Frances
Published: February 2023

Like all disciplines in higher education, the teaching of digital writing was profoundly impacted by the COVID-19 pandemic as faculty and students moved to emergency remote teaching (ERT). Rapid shifts to synchronous and asynchronous online delivery modes reshaped classrooms built upon frequent peer review and student collaboration in writing, forcing students and faculty into educational technologies that raised issues of privacy, equity, and surveillance. Yet, digital writing faculty responded to these challenges in ways that prioritised individual autonomy of student writers with creative assessments, improved access to texts, thoughtful connections to employers and audiences beyond the academy, and enhanced classroom collaborations via digital technologies. As this Editorial explores, the story of digital writing pedagogy during the pandemic became the story of a constant push and pull with the technologies that created digital writing itself. And just as teachers of digital writing began to emerge from the disruptions of the pandemic, a new wave of digital writing technologies enter the mix: AI-powered writing generators have arrived via applications such as ChatGPT with the seeming potential to shape the role of digital literacy once again. As this Editorial argues, the technologies of digital writing can be harnessed to reflect the values of education – openness, individual autonomy, and the power of knowledge – but only when the practitioners of digital writing pedagogy understand and access digital writing tools. At this time, those tools are again in rapid flux and the digital writing landscape remains profoundly unsettled.
“Learning from weakness is also valuable”: A reflection on digital peer writing workshops held during the COVID-19 pandemic
Authors: Pâquet Lili
Published: February 2023

In 2019, I refreshed a tertiary writing unit in which, across two assignments, students planned and then produced their own creative non-fiction work. Peer workshopping was an important pedagogical tool to help students bridge the gap between their creative non-fiction plan and their final submission. In the discipline of Writing, peer workshopping is central to students’ degrees, allowing them to develop a collective wisdom that is difficult to replicate in digital learning environments. My regional institution offers “digital first” degrees, and around 90% of my students learn online. Therefore, I created workshops online in asynchronous, written form, to suit our cohort of mostly mature age students with many commitments alongside study. During the unit, many students expressed troubles in using online programs such as Google Docs, prompting me to reflect on how to best meet their learning needs. Students took part in focus groups, which formed the basis of my subsequent revision of the digital workshops in the unit’s 2021 iteration. The need for digital adaptations of disciplinary pedagogies became even more broadly relevant by 2021, as more universities moved online during the pandemic in an Emergency Remote Learning response, and many remain online post-pandemic. Reflecting on my improved 2021 workshops, I ask, how can the writing workshop be successfully replicated in an asynchronous digital space? My response will reflect on 2021 survey feedback on the outcomes of my revisions in digital skills instruction and managing students’ time investment.
Students’ perceptions towards the application of peer assessment in a virtual English writing class
Authors: Vo Thi Kim Anh , Nguyen Ngoc Hong
Published: February 2023

Writing skills are not easy to develop in English language learning, especially when online learning is being implemented amid the COVID-19 pandemic. In order to improve students’ writing skills, as well as increase students’ autonomy, peer assessment is often adopted. The article presents findings of the research conducted in late 2021 on students’ perceptions towards the use of peer assessment in an online English writing class in Vietnam. The research applied a mixed method model with a questionnaire and an interview as the instruments. The questionnaire has 18 items divided into 4 parts: students’ personal information, students’ attitudes towards peer assessment, advantages of peer assessment, and disadvantages of peer assessment. The participants were 97 English as a Foreign Language (EFL) students who experienced one semester studying “Advanced Writing Skills” in online classes. The findings of the research revealed that students had negative attitudes towards the application of peer assessment to improve writing skills and they shared ideas of advantages and disadvantages of peer assessment. It is recommended that specific guidelines on how to do peer assessment with samples should be provided before teachers implement this teaching technique in class. In addition, in online classes, teachers need to be aware of making students familiar with peer assessment, as well as in the virtual environment.
Lexical features and the quality of Vietnamese EFL students' online English writings
Authors: Huong Pham Thi Thu , Phúc Trần Hữu
Published: February 2023

The rapid development of high technology and the Internet has made online learning increasingly popular, especially in the last few years when the COVID-19 pandemic appeared and spread worldwide. However, implementing online English courses in the pre-COVID-19 period was not prevalent; and only a few courses utilized new technologies to teach the English language online in universities and colleges in Viet Nam (Pham, 2020). This paper investigates 270 Vietnamese tertiary students' digital competency and online English writing study and practice experience in pre-, during, and post-COVID-19 periods. It also examines the link between the lexical features and the quality of the students’ online English writing. In addition, the study surveys English teachers' perceptions of lexical features' influence on the students' online English writing quality. The study found that Vietnamese tertiary students' digital competencies are of a high standard, with plentiful experiences of using digital technology in learning and practicing English. Some students faced challenges such as performing digital devices, communicating with friends and teachers, reading guides and documents in English, or having financial issues while taking online English courses during the COVID-19 pandemic. However, most of them solved all problems quickly and effectively themselves. Moreover, the findings implicated the strong influences of lexical sophistication, lexical diversity, and language accuracy on the students' English writing quality. Finally, it showed teachers' approval for students to use English writing aids when learning or practicing writing English online because of the educational benefits and convenience they could get in online English learning sessions.
Atezolizumab plus Bevacizumab as a Bridge for Liver Transplant in Hepatocellular Carcinoma
Authors: Solino Gabriela Azevedo , Ferreira Raphael Paiva Cock Paiva Cock , D’Albuquerque Luiz Augusto Carneiro , Farias Alberto Queiroz , Trindade Lívia Zardo , Vasconcelos Vitor Fiorin de , Pacheco Mariana Poltronieri
Published: February 2023

We report the case of a 68-year-old male with alcohol-related cirrhosis, diagnosed with hepatocellular carcinoma (HCC) not eligible for liver transplant. After immunotherapy with atezolizumab associated with bevacizumab, he underwent a successful living donor liver transplantation (LT), not showing disease evidence or graft injury, maintaining clinically and radiologically stable 14 months after surgery. This is a successful report of combined atezolizumab plus bevacizumab being used as a bridge to LT in a patient with HCC, showing an important finding in therapy in patients with unresectable tumors at diagnosis.
Analysis of Temperature During Storage and the Period of Warm Ischemia of the Graft in Kidney Transplants
Authors: Lima André Carminati , Alves Juliana Carpilovsky Revoredo , Borga Ana Lavratti , Ocampos Henrique Brambilla de Lucca , Deboni Luciane Mônica , Guterres Jean Cristovão Pereira , Garcia Christian Evangelista
Published: February 2023

Objective: This study aims to analyze the temperatures of kidney transplants performed at Hospital Municipal São José, Joinville/SC, throughout the period of cold ischemia and whether this temperature is in line with what is recommended in the literature. Method: Prospective analysis based on all kidney grafts that was used for kidney transplant in the unit of kidney transplant of Hospital Municipal São José. Results: The study analyzed that the current method of graft conservation partially meets the expected values, to maintain the recommended temperature. Conclusion: It is important to maintain studies and analyzes on the subject for continuous improvement in graft storage.
PubCast - Big Catch, Undecided Risks: Perspectives of Risk, Reward, and Trade-Offs in Alaska's Salmon Enhancement Program
Authors: Harrison Hannah L.
Published: February 2023

This article examines the human dimensions of hatcheries and stocking in Alaska's salmon enhancement program using interviews with key stakeholder groups throughout the Gulf of Alaska.

This paper was authored by Hannah L. Harrison and Julie Grønsleth Gould.

This paper was originally published in the North American Journal of Fisheries Management.
Síntomas depresivos en hombres privados de libertad en el establecimiento carcelario Bellavista
Authors: Acosta Tobón Sergio Andrés , Mosquera Perea Karen Margarita , Córdoba Moreno Lucy Marcela , Murillo Urrego Leidy Daniela , Galeano Bonilla Anjy Kathalina
Published: February 2023

El presente estudio buscó comprender la influencia de la privación de la libertad (PL) en síntomas depresivos en hombres condenados en el Establecimiento Penitenciario de Mediana Seguridad y Carcelario de Medellín - Bellavista, mediante un diseño de investigación cualitativo con una muestra de tres internos, quienes voluntariamente participaron en encuentros de entrevistas semiestructuradas. El análisis de los datos recolectados se interpretó desde la psicología posracional. Como resultado relevante se encontró la importancia de comprender la realidad del interno desde las necesidades de adaptación a los entornos, para garantizar la supervivencia en el centro penitenciario que implica entender tanto la subcultura carcelaria como constreñir las emociones.
La satisfacción laboral en las pymes venezolanas: un estudio de caso en la industria textil
Authors: Vargas Eduardo , Leidenz Marcel , D'Armas Mayra
Published: February 2023

La satisfacción laboral es un tema de mucha atención tanto en el mundo empresarial como en el académico; su impacto en la eficiencia y desempeño organizacional ha sido objeto de debate e investigación, encontrándose relaciones significativas entre este constructo y otras variables como ausentismo, motivación, rotación, entre otras. El objetivo de esta investigación es identificar los factores que determinan la satisfacción laboral en una empresa textil venezolana.  Para este fin se seleccionó como base la Escala de Satisfacción general, por su amplia aplicación en diferentes contextos. Los resultados permitieron determinar el nivel de satisfacción general de la empresa, así como los aspectos mejor y peor valorados. Así mismo, se identificaron tres (3) factores que determinan la satisfacción en la empresa: estructura organizacional, perfil del cargo, y, condición del cargo. La escala, aunque con otra estructura diferente a la propuesta, presentó consistencia interna (fiabilidad) en sus factores, y evidencia de validez, con resultados significativos (al 5%) para las pruebas estadísticas realizadas. Finalmente, la escala puede ser aplicada en otros contextos; sin embargo, los factores intrínsecos y extrínsecos pueden estará agrupados según las condiciones de cada organización.
Improvement of accounting and audit of intellectual property
Authors:   Department of Accounting Tashkent State university of economics, Tashkent, Uzbekistan, berganovich Davletov I. R. , Davlatbayevich Dusmuratov R. ,   Department of Accounting Tashkent State university of economics, Tashkent, Uzbekistan
Published: February 2023

The article explores the possibilities of using methods for analyzing the effectiveness of the use of intellectual property objects in the course of an audit. The article formulates proposals on the use of methods for analyzing the effectiveness of the use of intellectual property objects at the stages of the audit. An exemplary form of an intellectual property audit program using analytical operations is also proposed. The proposed approach to the implementation of a comprehensive analysis of the effectiveness of the use of intellectual property objects during the audit makes a certain contribution to the development of the audit methodology.
Digital Analysis in Hip Circulation and Biomechanical Changes in The Lower Limb in Perthes' Disease
Authors:   Republican specialization scientific, practical medical center of traumatology and orthopedics of the ministry of health, Uzbekistan, Djurabayevich Khalimov R.
Published: February 2023

Worldwide, the treatment of Perthes' disease in children and adolescents is a complex and unresolved problem. This is a common pathology that, with timely detection and proper therapy, is successfully treated, but in their absence can provoke the development of severe complications and cause early disability. Improving the results of treatment and rehabilitation of children with Legg-Calve-Perthes disease. Our research is based on archival data and on survey observation using digitalization, the total number of patients is 150 children with Legg-Calve-Perthes disease on inpatient treatment at the pediatric orthopedics clinic of the RSSPMC of Traumatology and Orthopedics of the Ministry of Health of the Republic of Uzbekistan for the period from 2008 to 2022. All patients had previously undergone conservative treatment of congenital hip dislocation. In the early stages of the pathology, 69.6% of children aged 3-6 years complained of fatigue in the hip joint after a long walk or run but did not notice pain. An orthopedic device has been developed to achieve maximum unloading of the hip joint when walking. The proposed device is convenient and when used, maximum unloading of the hip joint is achieved when walking.
Effectiveness of Online Learning with the Web-based TPACK Scaffolding for Enhancement TPACK Ability of Pre-service Chemistry Teachers
Authors: Astari Mardhiyah Ayu , Masykuri Mohammad , Susilowati Endang , Yamtinah Sri
Published: February 2023

This study investigates the effectiveness of web-based TPACK scaffolding to enhance the TPACK ability of pre-service chemistry teachers through online learning. Participants in this study were 74 pre-service chemistry teachers in Chemistry Education program who took a chemistry learning planning course. This study used the quantitative research method approach. The experimental study with pre-and post-test design examined the more significant increase in TPACK ability between the experimental and control classes. The research instrument consisted of 20 multiple-choice questions containing the TPACK components. Analysis of pre-and post-test data used the stacking and racking method in the Rasch model. The stacking analysis result indicated that the pre-service chemistry teachers' ability increased from pre-test to post-test. The racking analysis result indicated that the pre-service chemistry teachers could answer TPACK items easier in the post-test conditions after being given intervention. The various types of scaffolding available in web-based TPACK online learning effectively support pre-service chemistry teacher TPACK ability enhancement. Online learning with web-based TPACK scaffolding is advisable to develop pre-service chemistry teachers' TPACK to prepare them better to use various types of technology in classroom learning.
First Steps to Research: Typical Mistakes That Undergraduate Students Make When They Approach Academic Writing
Authors: Oshchepkova Tamara
Published: February 2023

Research-based projects are traditionally targeted at senior undergraduate or postgraduate students. In this paper, we advocate teaching research skills to freshmen rather than older students. Academic writing might be a challenge for university freshmen, especially if their previous learning experience has not involved composing a structured written text that clearly presents the writer’s point of view and supports it with facts and statistics from scholarly sources. The author analyses the problems that freshmen might face in the initial stages of research skills development and offers classroom activities that could help students overcome difficulties related to selecting sources and integrating them into the written text. At the beginning, a brief literature review is presented, which illustrates that the problem of freshmen academic writing has not been researched sufficiently. In the section Discussion, the author shares some examples of activities targeted at solving typical problems that freshmen face while writing research-based papers. For instance, among the suggested activities are those that might help students a) learn to differentiate between reliable and unreliable sources; b) decide on the length of the cited excerpt; and c) make judgements about the relevance of the selected source to the purpose of the research paper. Davidson (2018) referred to course-based research as ‘a new pedagogical paradigm’. The author of this paper supports this opinion and emphasises that such a paradigm should be applied in the earlier stages rather than at the level of PhD or Masters studies, which might yield a significant improvement.