bluuebunny/crossref_metadata_2025 huggingface dataset:
Patient Perspectives on Key Symptoms and Preferences for Follow-up After Upper Gastro-intestinal Cancer Surgery
Authors: Pucher Phillip H , Coombes Annie , Evans Orla , Taylor Joanna , Moore Jonathan L , White Annabelle , Lagergren Jesper , Baker Cara , Kelly Mark , Gossage James A , Dunn Jason , Zeki Sebastian , Byrne Ben , Andreyev Jervoise , Davies Andrew R
Published: November 2021

Purpose: Long-lasting symptoms and reductions in quality of life are common after oesophago-gastric surgery. Post-operative follow-up has traditionally focussed on tumour recurrence and survival, but there is a growing need to also identify and treat functional sequelae to improve patients’ recovery.Methods: An electronic survey was circulated via a British national charity for patients undergoing oesophago-gastric surgery and their families. Patients were asked about post-operative symptoms they deemed important to their quality of life, as well as satisfaction and preferences for post-operative follow-up. Differences between satisfied and dissatisfied patients with reference to follow-up were assessed.Results: Among 362 respondents with a median follow-up of 58 months since surgery (range 3-412), 36 different symptoms were reported as being important to recovery and quality of life after surgery, with a median 13 symptoms per patient. Most (84%) respondents indicated satisfaction with follow-up. Unsatisfied patients were more likely to have received shorter follow-up than 5 years (27% among unsatisfied patient vs. 60% among satisfied patients, p<0.001) and were less likely to have seen a dietitian as part of routine follow-up (37% vs. 58%, p=0.005).Conclusion: This patient survey highlights preferences regarding follow-up after oesophago-gastrectomy. Longer follow-up and dietician involvement improved patient satisfaction. Patients reported being concerned by a large number of gastrointestinal and non-gastrointestinal symptoms, highlighting the need for multidisciplinary input and a consensus on how to manage the poly-symptomatic patient.
Detecting Bone Lesions in The Emergency Room With Medical Infrared Thermography
Authors: Strasse Wally auf der , Campos Daniel Prado , Mendonça Celso Júnio Aguiar , Soni Jamil Faissal , Mendes Joaquim , Nohama Percy
Published: November 2021

Introduction: Low to high-energy impact trauma may cause from small fissures up to extended bone losses, which can be classified as closed or opened injuries (when they are visible at a naked eye). Objective: The aim of this study was to investigate the feasibility of clinical diagnosis of bone trauma through medical infrared thermography, in a hospital emergency room. Methods: Forty-five patients with suspected diagnosis of bone fracture were evaluated by means of medical infrared images, and the data correlated to the gold standard radiographic images, in the anteroposterior, lateral, and oblique views, at the orthopedic emergency department. The control group consisted of thermal images of the contralateral reference limb of the volunteers themselves. Data were acquired with a medical grade infrared camera in the regions of interest (ROIs) of leg, hand, forearm, clavicle, foot, and ankle. Results: In all patients evaluated with a diagnosis of bone fracture, the mean temperature of the affected limb showed a positive difference greater than 0.9 °C (towards the contralateral), indicating the exact location of the bone trauma according, while the areas diagnosed with reduced blood supply, showed a mean temperature with a negative variation. Conclusion: Clinical evaluation using infrared imaging indicates a high applicability potential as a tool to support quick diagnosis of bone fractures in patients with acute orthopedic trauma in an emergency medical setting. The thermal results showed important physiological data related to vascularization of the bone fracture and areas adjacent to the trauma well correlated to radiographic examinations.
Unfolding Water Quality Status During COVID-19 Lockdown for the Highly Polluted Santiago River in Jalisco, Mexico
Authors: Kutralam-Muniasamy Gurusamy , Pérez-Guevara Fermín , Martinez Ignacio Elizalde , Chari Shruti Venkata
Published: November 2021

The Santiago River is one of Mexico's most polluted waterways and evaluating its surface water quality during the COVID-19 outbreak is critical to assessing the changes and improvements, if any, from the nationwide lockdown (April-May 2020). Hence, the data for 12 water quality parameters from 13 sampling stations during April-May 2020 (lockdown) were compared with the levels for the same period of 2019 (pre-lockdown) and with the same interval of previous eleven-years (2009-2019). The values of BOD (14%), COD (29%), TSS (7%), f. coli (31%), t. coli (14%) and Pb (20%) declined, while pH, EC, turbidity, total nitrogen and As enhanced by 0.3-21% during the lockdown compared to the pre-lockdown period suggesting decrements of organic load in the river due to the temporary closure of industrial and commercial activities. An eleven-year comparison estimated the reduction of pH, TSS, COD, total nitrogen and Pb by 1-38%. The analysis of water quality index estimates showed short-term improvements of river water quality in the lockdown period, compared to pre-lockdown and eleven-year trend as well as indicated very poor quality of the river. The contamination sources identified by factor analysis were mainly related to untreated domestic sewage, industrial wastewaters and agriculture effluents influencing the river water quality. Overall, our findings demonstrated positive responses of COVID-19 imposed lockdown on water quality of the Santiago River during the study period, providing a foundation for the government policy makers to identify the sources of pollution, to better design environmental policies and plans for water quality improvements.
Integrated Analysis of CO2 Emission Intensity, Bilateral FDI, and Institutional Quality Nexus: Case Study of G20 Countries
Authors: Tripathy Prajukta , Khatua Monalisa , Behera Pragyanrani , Satpathy Lopamudra D. , Jena Pabitra Kumar , Mishra Bikash Ranjan
Published: November 2021

A clean natural environment is a primary concern of contemporary lives, business investments, and governments. However, there is a lack of knowledge of how countries can achieve high investment across borders and better institutional quality while protecting the environment. Thus the current paper explores the effect of bilateral FDI, institutional quality, and CO2 emission intensity on each other for 19 selected G20 countries over the 2009-2017 periods. This paper estimates the three equations that jointly address the endogeneity problem by employing both static and dynamic simultaneous econometrics techniques with a panel dataset. The empirical results confirm that bilateral FDI reduces CO2 emission intensity and strengthens the institutional quality in G20. The results also support a positive and significant effect of institutional quality on bilateral inward FDI and CO2 emission intensity. This paper confirms a positive and considerable feedback effect of CO2 emission intensity on institutional quality. Further, this study establishes a triplex relationship between these three factors and consolidates vital policy insights to achieve sustainable growth concerning the nexus among environment quality-FDI-institution quality for G20 economies.
Detecting Disease Association With Rare Variants Using Weighted Entropy
Authors: Li Yumei , Xiang Xinrong , Xiang Yang
Published: November 2021

BackgroundThe rapid development of sequencing technology and simultaneously the availability of large quantities of sequence data provides an unprecedented opportunity for researchers to conduct studies to detect rare variants associated with the disease. However, none of current existing statistical methods has uniform power in all scenarios because they more or less are affected by nonfunctional variants and variants with opposite effect. The present study focuses on identifying rare variant associated with the disease.Resultswe present a robust approach to identify rare variant using weighted entropy theory.This approach here takes the proportion of the minor allele among all k variants as its probability distribution, which reduces the noise incurred by non-causal variants, and uses a weight to strike a balance between deleterious rare variants and protective rare variants, which makes our method impacted less by variants with opposite effect. Through simulation studies, we investigate the performance of our method for rare variant association analyses as well as for common variant association analyses and compared it with Burden test and the SKAT-O test. Simulation study show that the proposed method is valid and outperform two existing methods. Meanwhile, the proposed method is affected slightly by non-causal variants and opposite effect variants with high and stable power for various paraments set.Conclusions﻿We conclude that the proposed method here can be used effectively to detect rare variant associated with the disease.
Comparison between fasting and non-fasting cut-off values of triglyceride in diagnosing high triglyceride in Chinese hypertensive outpatients
Authors: Xie Yingying , Qu Peiliu , Liu Ling , Du Xiao , Zhang Shilan , Guo Liling , Xiang Qunyan , Lin Qiuzhen , Xu Jin , Zhu Liyuan , Tan Yangrong , Fu Yan , Zhang Miao , Zang Xueyan , Wen Tie
Published: November 2021

Background

Hypertension (HBP) often occurs together with hypertriglyceridemia that indicates elevated triglyceride (TG) and remnant cholesterol (RC) levels. Non-fasting (i.e. postprandial) blood lipid test after a daily meal has been recommended by the European Atherosclerosis Society (EAS). However, little is known about the difference between fasting and non-fasting cut-off values in assessing high TG (HTG) and high RC (HRC) in HBP outpatients.
Methods

Two hundred and twenty-five Chinese outpatients with HBP were enrolled in this study. According to the time of blood lipid test, they were divided into two groups, i.e. the fasting group (n=119) and the non-fasting group (n=139). Non-fasting levels of blood lipids at 2 h after a daily breakfast were also tested in 33 patients among the fasting group. Venous blood samples were collected. Serum levels of blood lipids were measured by the enzymatic and direct methods on a HITACHI 7170A analyzer or estimated via related formulas.
Results

The non-fasting group had significantly higher levels of TG and RC while lower levels of total cholesterol, low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol than the fasting group (P༜0.05). According to TG and RC cut-off values of the EAS, the percentages of HTG and HRC in the non-fasting group were 67.6% and 65.6%, respectively, while those in the fasting group were 57.1% and 52.9%, respectively. However, the percentages of HTG in the fasting state and at 2 h after a daily breakfast in 33 outpatients did not reach statistical significance (57.6% v.s. 51.5%). So did the fasting and at 2 h non-fasting percentages of HRC in them.
Conclusion

Non-fasting blood lipid test could find more HBP outpatients with HTG in Chinese outpatients with HBP. However, the percentage of HTG at 2h after a daily breakfast seemed to be close to that in the fasting state.
An Ultrasonic Accelerated Three-Component Condensation By KCC-1: A High Mechanical Stability Silica Nanospheres As A Good Catalyst For Ultrasonic Irradiation
Authors: Oboudatian Hourieh Sadat , Safaei-Ghomi Javad
Published: November 2021

Fibrous nano-silica sphere (KCC-1) has appeared as a good and efficient catalyst for ultrasonic irradiation conditions in chemical reactions. This catalyst has the unique properties such as a fibrous surface morphology, high surface area and high mechanical stability. The results indicated that the KCC-1 nanocatalyst could be used as high-performance catalysts under high temperature and pressure condition in organic reaction under ultrasonic irradiation. Morphology, structure, and composition of the fibrous nano-silica sphere were described by N2 adsorption–desorption analysis, scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray powder diffraction (XRD), thermogravimetric analysis (TGA) and Fourier-transform infrared spectroscopy (FT-IR). In this work, we used KCC-1@NH2 nanosilica as a basic catalyst for the preparation of chromenes under ultrasonic irradiation conditions for the first time. The recyclability, nontoxicity and high stability of the catalyst, combined with low reaction times and excellent yields, make the present protocol very useful for the synthesis of the title products under ultrasonic conditions. The produced products were confirmed via 1H NMR, 13C NMR, FT-IR analysis.
Proteome Expression Profile for Red Blood Cells Enables Diagnostics for Hepatocellular Carcinoma
Authors: Wang Shufang , Wang Guibin , Lu Shichun , Zhang Jiaying , Zhang Wenwen , Han Yuanyuan , Cai Xiaoyu , Zhuang Yuan , Pu Fei , Wang Liang , Huang Xirui , Fan Bin , Wang Deqing , ZHANG Zhaojun
Published: November 2021

BackgroudEarly diagnosis of hepatocellular carcinoma (HCC) has not been clinically resolved, which has been causing more death in patients with HCC. HCC is also a systemic disease related to disorders of blood homeostasis, and the association of red blood cells (RBCs) and HCC tumorigenesis is still elusive. This study explored the protein characteristics of RBCs at the progressive pathological stages comparing with healthy individuals, including liver cirrhosis (LC) and established HCC, to fully understand the tumorigenesis of HCC from a different view and identify potentially novel diagnostic biomarkers for HCC in RBCs.MethodsData independent acquisition (DIA) proteomic analyses were performed with 72 clinical RBCs samples from a cohort of subjects including HCC, LC and healthy controls. Bioinformatics analysis was conducted for significantly differentially expressed proteins (DEPs) through the whole process of tumorigenesis to characterize the clinical relevanve of RBCs and tumorigenesis in HCC. The highly potential tumorigenesis-associated molecular biomarkers were evaluated with clinical samples by parallel reaction monitoring (PRM) technology.ResultsWe observed that red blood cells number dynamically changes during the tumorigenesis of HCC, and LC is a developmental stage more closely approaching HCC based on the protein expresson profiles in RBCs. The expression of hemoglobin (HbA, HbF) in erythroid cells also dynamically alters during the whole process of HCC tumorigenesis, suggesting immature erythroid cells exist in peripheral blood of HCC patients and erythropoiesis in the patients starts to be influenced with the occurance of LC. We observed that the autophagy pathway is disturbed in RBCs with the onset of LC and maintained during the tumorigenesis of HCC. Oxytocin pathway and GnRH pathway are disturbed and first identified during the development of LC into HCC. SMIM1, ANXA7, HBA1 and HBE1 that are significantly altered during tumorigenesis were verified as promising biomarkers for HCC early diagnosis.ConclusionsThis study underlied the clinical relevance of the proteins in RBCs and the tumorigenesis of HCC, and provided the potential biomarkers for early diagnosis in HCC from a new perspective. Our results provided a novel strategy with RBCs for HCC early diagnosis, which will improve the translational research and application in diagnosis of HCC.
Oblique Lateral Interbody Fusion Combined With Different Internal Fixations in The Treatment of Degenerative Lumbar Spine Disease: A Finite Element Analysis
Authors: Zhang ShuYi , Liu Zhengpeng , Lu Chenshui , Zhao Li , Feng Chao , Wang Yahui , Zhang Yilong
Published: November 2021

Little is known about the biomechanical performance of various internal fixations in oblique lumbar interbody fusion (OLIF). In this study, finite element (FE) analysis was used to describe the biomechanical findings of various different internal fixations to compare and explore the stability of each fixation.METHODS: Six validated FE models of the L3-S1 segment were reconstructed from computed tomography images, including (1) an intact model, (2)a stand-alone (SA) model with no instrument (3) a unilateral pedicle screw model (UPS), (4) a unilateral pedicle screw contralateral translaminar facet screw model (UPS-CTLFS), (5) a bilateral pedicle screw (BPS) model, and (6) a cortical bone trajectory screw (CBT).Three-dimensional model was performed by computed tomography data, and 150N static force and 10N.m moments in different directions were applied to the models to analyze the validation of the models in comparison with previous studies. Models of the OLIF cage was created with three-dimensional scanning to improve the accuracy of the FE analysis. Range of motion (ROM) of the surgical segment stresses, stress of the cage, and stress of fixation were evaluated in the different models.RESULTS:ROM increased from least to greatest as follows: BPS, UPS-CTFS, CBT, UPS, SA. The SA group had the greatest ROM and the SA group had the greatest ROM and stresses on the CAGE. The ROM of the BPS and UPS-CTFS was not significantly different for all motion loadings. Compared with the other three models, the BPS model had lower stresses in internal fixation for all loading conditions and the CBT screw internal fixation had the highest stresses for different loads Compared with the other groups.CONCLUSIONSThe BPS model provided the best biomechanical stability for OLIF. The SA model was relatively less stable. The UPS-CFTS group reduced the ROM of the fusion segments, but the stresses on the internal fixation and CAGE were relatively higher in the UPS-CFTS Compared with the BPS group; and the CBT group had lower ROM in flexion and extension Compared with the BPS, but its ROM in rotation and lateral flexion was relatively higher. The stability of the CBT was poorer than that of the BPS and LPS-CTFS groups. The stress on the CAGE and internal fixation was greater in the CBT group.
Ex-vivo Nachweis der Polarität zirkulierender Tumorzellen bei Patienten mit Hepatozellulärem Karzinom
Authors:   , Friedrich Babette Margarete
Published: November 2021

Das Hepatozelluläre Karzinom (HCC) steht weltweit an dritter Stelle tumorbedingter Todesursachen. Eine kurative Therapie durch Leberresektion oder Transplantation ist nur dann Erfolg versprechend, wenn der Patient in einem frühen Stadium diagnostiziert wird, in dem noch keine Fernmetastasen oder Gefäßinvasionen vorliegen. Die Ausbildung von Mikrometastasen sind mittels Bildgebung nicht detektierbar. Mit Hilfe der „liquid biopsy“, einem Blutanalyseverfahren, das sich auf die Detektion zirkulierender Tumorzellen (CTCs) im Patientenblut fokussiert, ist es m glich, diese Tumorzellen im Anschluss an ihre Isolation auf ihre molekularen Eigenschaften hin zu untersuchen. Im Laufe des Metastasierungsprozesses kommt es zur De- und Repolarisierung der CTCs. In der vorliegenden Promotionsarbeit wurde ein immunologisches Verfahren zur Detektion polarisierter Tumorzellen (p-CTCs) im Blut von Patienten mit HCC entwickelt. Dazu erfolgte zunächst die Isolation der CTCs mittels Dichtegradientverfahren (Oncoquick@, Fa. Greiner bio-one) und die anschließende Immunfluoreszenzfärbung der CTCs mittels Anti-Ezrin-Alexa- Fluor 488  zum strukturellen Nachweis des zytoskelletalen Membranproteins Ezrin. Anhand der Lokalisation des Ezrin innerhalb der CTCs war es m glich, die CTCs in polarisierte(p-CTC) und nicht-polarisierte Zellen (non-polarized CTC) zu unterteilen. Mit diesem Verfahren konnten in einem Zeitraum von Juni 2018 bis Januar 2019 Blutproben (5 ml/Patient) von 15 Patienten mit HCC und von 10 Patienten mit einer nicht malignen Lebererkrankung (NMLD) untersucht werden. Die häufigste Grunderkrankung war mit 30,43% (n=7) C2 Abusus, gefolgt von der NASH mit 26% (n=6) und DM Typ 2 mit Leberzirrhose mit 13,04% (n=2). 10 (66,6%) HCC-Patienten hatten eine Leberzirrhose. Bei einem Patienten war die Tumorgröße <2 cm, bei 7 Patienten zwischen 2-5 cm, und 7 Patienten hatten eine Tumorgröße von > 5 cm. Die meisten Patienten hatten ein BCLC-Stadium C (n=7), gefolgt von BCLC-Stadium B (n=4), und BCLC-Stadium D (n=3) und nur ein Patient hatte ein BCLC-Stadium 0. In 14 (93,3%) HCC-Patienten konnten CTCs 1,2 CTCs/ml (0,4-3 CTCs/ml) nachgewiesen werden. Die Falsch-Positiv-Rate lag bei 0,2 isolierte Zelle/ml (p=0,0006). P-CTC konnten in 10/14(71%) HCC-Patienten identifiziert werden. Die HCC-Gruppe wies mit 0,42 p-CTCs/ml signifikant mehr p-CTCs als die NMLD-Patienten(0 p-CTCs/ml, p=0,002). Eine negative Korrelation fand sich zwischen der Tumorgröße, BCLC-Stadium und der Anzahl polarisierter CTCs (r=-0,029, p=ns). Die hier vorgestellten Daten zum Nachweis der Polarisierung von CTCs in Zusammenhang mit HCC könnten zukünftig eine Rolle in der molekularen Charakterisierung von CTCs und der Diagnose des HCC darstellen.
The Effect of Soya and Genistein Supplementation on Serum Lipid Profile of Male Dawley Sprague Rat
Authors: Nasution Muhammad Imanuddin , Arsana Putu Moda
Published: November 2021

Background: Non-medical therapy is needed to reduce blood lipid levels and prevent atherosclerosis. Foods that contain Isoflavones can improve lipid profiles in the blood.Aim: To determine the effect of soya and genistein supplementation in various doses on total cholesterol, Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), Triglycerides in male Sprague-Dawley rats.Methods: 35 male Sprague-Dawley rats aged 6-8 weeks were divided into 7 groups, control group; low, medium, and high doses of soy milk; and low, moderate, and high doses of genistein. The treatment was given orally for 60 days. The control used was mice with standard feed. On the 61st day, blood and hepatic tissue samples were taken and checked for lipid profiles using the Friedewald formula. Statistical analysis was carried out by one-way ANOVA and Tukey's posthoc test and Dunnet test, then regression analysis.Results: There was a significant increase in total cholesterol levels (p <0.05) and Â LDL levels in low and moderate doses of soy milk group compared to all groups of genistein. There was no significant differences in HDL levels in soya and genistein groups. There was significant increase in Triglyceride levels in all groups of soy milk and low and moderate doses of Genistein compared to high doses of genistein.Conclusion: Â Soya and genistein supplementation had increased effect on the Total Cholesterol, LDL and Triglycerides but no effect on HDL in all groups.
Lo que aprendimos a un año de haber comenzado la pandemia
Authors: Sánchez Vázquez Alan
Published: November 2021

Resulta importante hacer una reflexión en retrospectiva acerca del momento histórico en que nos encontramos como estudiantes, profesores y seres humanos. Es evidente que las dimensiones educativa y social se han visto trastocadas a un año de haber iniciado el confinamiento estricto en México y en el mundo. Muchas cosas se modificaron, pero ¿cómo lo estamos sobrellevando?
En este breve artículo, se hace un repaso sobre lo que hemos cambiado y mejorado, y que, una vez que regresemos a la llamada “nueva normalidad”, integraremos en nuestra nueva vivencia, desde lo académico hasta los aspectos social y emotivo.
Movie Recommendation System Mistreatment Current Trends and Sentiment Analysis from Micro Blogging Knowledge
Authors: Manikandan J
Published: November 2021

Abstract: Recommendation systems (RSs) have garnered immense interest for applications in e-commerce and digital media. Traditional approaches in RSs include such as collaborative filtering (CF) and content-based filtering (CBF) through these approaches that have certain limitations, such as the necessity of prior user history and habits for performing the task of recommendation. To minimize the effect of such limitation, this article proposes a hybrid RS for the movies that leverage the best of concepts used from CF and CBF along with sentiment analysis of tweets from microblogging sites. The purpose to use movie tweets is to understand the current trends, public sentiment, and user response of the movie. Experiments conducted on the public database have yielded promising results. Keywords: Collaborative filtering, Content based filtering, Recommendation System, Sentiment Analysis, Twitter
Effect of Cinnamaldehyde on Female Reproductive Hormones in 7, 12 Dimethyl Benzanthracene Induced Ovarian Cancer Rats
Authors: Boggiti Madhuri
Published: November 2021

Abstract: Ovarian cancer is the deadliest type of cancer in women. It is often presented at an advanced stage and has a poor prognosis. The current treatment methods for this tumor are not safe and have serious side effects. It has been suggested that the use of steroids for hormonal purposes is linked to the development of ovarian cancer. The current study aims to investigate the effects of cinnamaldehyde on these hormones. The objective of this study was to investigate the effects of cinnamaldehyde on the reproductive hormones of rats after being induced to develop ovarian cancer. Cinnamaldehyde is an active compound that has been used in Asia for over 4000 years. Cinnamaldehyde has different biological activities including antimicrobial, antiinflammatory, antiviral, antioxidant, antitumor were reported by many investigators. In the present study, animals were randomly allocated into VI groups: Group -I served as a control with normal water and group-II was drug control (50 mg/kg b. w) rats received only cinnamaldehyde orally for 36 weeks. The rats in group III were given a single dose of 7,12 Dimethyl benzanthracene (100 µg/rat) dissolved in 10 µL of sesame oil to surgically exposed left ovary and maintained up to 36 weeks to initiate ovarian carcinogenesis. Group IV rats received DMBA + cinnamaldehyde 50 mg/kg b. w (before starting the experiment and continued up to 24 weeks). Group V rats received DMBA + cinnamaldehyde 50 mg/kg b. w (25-36 weeks). Group VI rats received DMBA + cinnamaldehyde 50 mg/kg b. w (1-36 weeks). Serum levels of Estrogen, progesterone, LH, FSH were estimated using ELISA. The results showed that significant increase in serum level of Estrogen, LH, FSH, and decreased progesterone in only DMBA treated group when compared with control groups. Also, there was a significant decrease in serum levels of Estrogen, LH, FSH, and increased progesterone in cinnamaldehyde treated groups (dose-dependent) when compared to only DMBA treated group. The results of the present study suggested that cinnamaldehyde has anticancer activity and further investigations are needed for evaluating the anticancer potential and mechanism of its action. Keywords: Cinnamaldehyde, DMBA, Ovarian cancer, Reproductive hormones.
Work Allocating Strategy Using a Powerful Prioritized Tasks in Mobile Cloud Computing Atmosphere
Authors: Maddilety C.
Published: November 2021

Abstract: In recent times, users necessitate and expect more demanding criteria to perform computational in-depth applications on their mobile devices. Based on the mobile device limitations such as processing power and battery life, Mobile Cloud Computing (MCC) is turned to be a more attractive choice to influence these drawbacks as a mobile computation can be provided to the cloud, which is coined as Mobile computation deceive. Prevailing researches on mobile computation offloading determines offloading mobile computation to single cloud. Moreover, in real time environment, computation service can be offered by multiple clouds for every computation services. Therefore, a novel and an interesting research crisis in mobile computation offloading begins with, how to choose a computation service for every tasks of mobile computation like computation time, energy consumption and cost of using these computation services. This is also termed as multi-site computation offloading in mobile cloud computation. In this examination deceive computation to diverse cloudlets/data centres with respect to task scheduling is formulated for examination. So, a Searching algorithm known as Accelerated Cuckoo Search Algorithm based job splittingis designed to attain higher data transmission rate in the MCC. The results of the certain method outperform the prevailing methods in terms of effectual job splitting; transmission speed, Bandwidth used, execution time of a job, transmission value, through put value, buffering overhead and reduced waiting time. The simulation was carried out in Clouds environment for good output. Keywords: Computation Deceive, Mobile Cloud Computing, Scheduling, Searching Algorithm, WorkSplitting.
Attention to the State Language in the Educational Process
Authors: Muminovna Amanullayeva Kamola
Published: November 2021

Abstract: The main idea of the article is to further increase the focus on the state language, to use it wisely, aimed at replacing the educational process in achieving speech conformity to literary language norms among students and pupils. However, the author provided information on how important a teacher’s speaking skills in learning process. As well as, there are some information about speech culture. Keywords: state language, specialist, teacher, student, pupil, public speaking skills, language culture, to increase practice, oral and written speech.
Transfer Specifics of Spanish Realities into Russian
Authors: Komilovna Urunbayeva Dilnoza
Published: November 2021

Abstract: The article deals with the problem of the transfer of Spanish realities in translation. It was found out that the difficulties in translating realities, on the one hand, are due to the lack of an equivalent or analogue in the translation language, and on the other hand, the need to transfer the subject (semantic) meaning, taking into account the connotation (nationalhistorical coloring). As a result of the analysis of the translation text of the novel, it was found that translators mainly resort to such methods of translating realities as transcription, descriptive and approximate translation. Keywords: realities; transcription; transliteration; semantics; descriptive translation; approximate translation
Estimación de los parámetros del modelo de un solo diodo del módulo fotovoltaico aplicando el método de optimización basado en búsqueda de patrones mejorado
Authors: Tobon Mejia Andres  Felipe , Rojas Montano Jhon Jairo , Serna Garces Sergio Ignacio , Herrera Cuartas Jorge Aurelio
Published: November 2021

En este artículo se propone el uso de un algoritmo de optimización basado en la búsqueda de patrones mejorada, aplicándolo a la estimación de los parámetros modelo de un diodo de una célula fotovoltaica. Los parámetros a estimar son corriente fotovoltaica, la saturación de corriente del diodo, la resistencia serie, la resistencia en paralelo y el factor de idealidad del diodo. La estimación es hecha a partir de los datos obtenidos de una curva conocida, es decir, que la celda fotovoltaica puede caracterizarse y los parámetros son extraídos de los datos de la curva. Los resultados son la identificación de los parámetros y la exactitud del modelo con respecto a la referencia en el punto de máxima potencia (MPP). Adicionalmente se realiza una comparación con el modelo obtenido con tres estimaciones realizadas con el algoritmo de optimización enjambre de partículas (PSO), bajo las mismas condiciones en cantidad de partículas y de iteraciones. El error encontrado muestra la similitud del modelo con la referencia obtenida de acuerdo con el algoritmo IPSM.
Extraction of Student Interaction Data from an Open edX Platform
Authors: Jaramillo-Morillo Daniel , Solarte Mario , Ramírez-González Gustavo
Published: November 2021

The Massive Open Online Courses (MOOC) are courses available to the general public without restrictions that are offered to hundreds or thousands of students and in recent years have been presented as a revolution in online education. They are presented as an alternative to the great demand in higher education for the characteristic of being open and massive because they allow access to education to a huge number of students. They have become an ideal environment for data collection and through the application of learning analytics techniques they have allowed a better understanding of how students learn. However, access to the data from thecurrent open-source MOOC platforms is limited and often difficult to collect and process. This paper presents a proposal for collecting and processing the data from students’ interaction with the Open edX platform through Scripts and a Collector based on Java code.
Dose Banding -- weighing up benefits, therapeutic failure and risks
Authors: Duffull Stephen
Published: November 2021

Aim Dose banding is a commonly used method of dose individualisation in
which all patients with similar characteristics are allocated to the
same dosing group. Dose banding results in some patients receiving less
intensive treatment with the potential for a reduction in therapeutic
benefit (iatrogenic therapeutic failure). This study aims to explore the
effects of dose banding on therapeutic success and failure. Methods This
was a simulation study conducted using MATLAB. Virtual patients were
simulated under a simple pharmacokinetic model with a predefined target
steady-state average concentration (c_(ss,ave)). Clearance was
correlated with a covariate used for dosing. Dose individualisation was
based on: one-dose-fits-all, covariate based dosing, empirical dose
banding, dose banding optimised for benefit:risk only and dose banding
optimised for both benefit:risk and minimising iatrogenic therapeutic
failure. Results The lowest and highest probabilities of target
attainment (PrTA) were 46% for one-dose-fits-all and 72% for fully
individualised covariate-based dosing. Neither dosing approach would
result in iatrogenic therapeutic failure as lower dose intensities do
not occur. Empirical dose banding performed better than
once-dose-fits-all with 59% PTA but not as good as either optimised
method (64-69% PrTA) while carrying a risk of iatrogenic therapeutic
failure in 25% of patients. Optimising for benefit:risk (only) improved
PrTA but carried a risk of iatrogenic therapeutic failure of up to 10%.
Optimising for benefit:risk and minimising iatrogenic therapeutic
failure provided the best balance. Conclusion Future application of dose
banding needs to consider both the probability of benefit:risk as well
the risk of causing iatrogenic therapeutic failure.
Presencia y permanencia del concepto educación integral
Authors: Hoyos-Morales Jorge Ivan
Published: November 2021

En este artículo en primer lugar se hará una introducción al concepto de educación integral. Luego se mostrará la manera en que tal concepto ha estado presente en proyectos educativos progresistas y esencialistas de grandes instituciones educativas, planteados en la segunda mitad del siglo XIX y primeras décadas del XX, los cuales han tenido eco en Iberoamérica. Posteriormente se mostrará la presencia del concepto mencionado en proyectos de educación popular surgidos en España y Colombia en la segunda mitad del siglo XIX y del XX basados en el humanismo cristiano. Finalmente se verá la permanencia de la educación integral en los objetivos de proyectos educativos planteados desde la UNESCO; proyectos que han influido las leyes educativas de los países antedichos.
Development and scale-up of fully printable perovskite solar modules
Authors:   , Meroni Simone M.P.
Published: November 2021

Perovskite solar cells represent a new class of photovoltaic devices that, in only a decade, has already been achieved comparable performance to that of the most established photovoltaic technologies. To satisfy the demanding market require-ments, however, perovskite solar cells need to have the high performances with the use of low-cost materials and cost-eﬀective fabrication processes, during a long term in the working environment and this needs to be possible for both small scale and large-scale devices.The fully printable carbon perovskite solar cells are based on an inorganic triple mesoscopic stack that is inﬁltrated by a perovskite precursors solution. This architecture seems to be the most promising to satisfy the requirements of the market, because the manufacture can simply occur with low-cost materials and well-established industrial deposition techniques, such as screen printing. Further-more, the stability of these cells was reported to be one of the longest among perovskite solar cells, making this technology the closest to make market penetra-tion.This work focuses on fully printable perovskite solar cells with a special outlook at their up-scaling in series-connected modules. The fabrication of large area modules with both high performance and substrate coverage will be discussed, in a journey that starts from single cell devices, overcomes issues found in the up-scaling process, and ﬁnally reaches design optimisation. Devices of single cells with 1 cm2 active area will be presented, as well as modules on 5 × 5 cm2 or 10 × 10 cm2 substrates. Finally, series-connected modules with around 200 cm2 active area and high coverage on the substrate will be shown.
diálogo entre literatura e estudos de religião e teologia no Grupo de Pesquisa sobre Protestantismo, Religião e Arte da PUC Minas
Authors: Caldas Filho Carlos Ribeiro , Klautau Diego Genu
Published: November 2021

O artigo apresenta a trajetória do GPPRA – Grupo de Pesquisa sobre Protestantismo, Religião e Arte – do Programa de Pós-graduação em Ciências da Religião da PUC Minas e sua contribuição para o diálogo entre literatura e teologia no Brasil. O grupo, organizado em 2018, tem como um de seus eixos de investigação acadêmica o diálogo entre a literatura e os estudos de religião e a teologia. O artigo apresenta um diferencial da atuação do grupo, a saber, a “opção preferencial” (mas de modo algum exclusiva) pelas literaturas fantástica e de fantasia como seus objetos de estudo. No artigo são também apresentadas as principais referências teóricas para a hermenêutica literária e para o diálogo entre literatura e estudos de religião e teologia utilizados nas pesquisas do grupo, e, de igual maneira, para a análise dos autores aos quais o grupo dedica atenção especial, a saber, J. R. R. Tolkien e C. S. Lewis.
Analisis Fatwa DSN-MUI No. 25/DSN-MUI/2002 Tentang Pelelangan Barang di Pegadaian Syariah
Authors: Srisusilawati Popon , Fitria Anisa , Eriska Selly , Sumarwan Tiara Deasy Nurfitriani , Juniar Nendiarti
Published: November 2021

In Islam, pawning is known as Ar-rahn, which is to make an item as collateral for debt, provided that if there is difficulty in payment, the debt can be paid from the sale of the goods used as collateral. In sharia pawnshops, the auction system applies to customers, if the customer is unable to redeem the pawned goods and pay their debts after maturity. An auction is an attempt to repay loans that cannot be repaid to a certain extent. Auctions according to sharia must also be accountable for Islamic law, which is free from elements of gharar, maisir, usury and falsehood. The auction mechanism in sharia pawnshops is regulated in the second part of the General Provisions for Fatwa DSN No.25 / DSN-MUI / 2002, point 5 concerning auction. The purpose of this research is to find out whether the sharia auction mechanism is in accordance with the fatwa or not. The method used in this writing is qualitative descriptive. The result of this research is that the sharia embedding mechanism is in accordance with the DSN-MUI Fatwa No. 25 / DSN-MUI / 2002 concerning Auctions.
Urgensi Kualitas Pelayanan Distribusi Zakat Produktif Terhadap Kepuasan Mustahiq
Authors: Mehilda Sukma , Meliyana Meliyana , Hendarsyah Decky
Published: November 2021

Productive zakat is something that can support productivity for the economy and mustahiq life. Mustahiq satisfaction in getting productive zakat is a reflection of the success of the service. This study aims to analyze the effect of the quality of productive zakat distribution services on mustahiq satisfaction at the national zakat agency (NZA) Bengkalis district. This study was built using a quantitative descriptive method based on primary and secondary data in questionnaires, documentation, and literature studies. The total population of productive zakat mustahiq at the NZA Bengkalis regency is 327 people. Sampling used random sampling with a total sample of 77 people. Data were analyzed using simple linear regression, previously tested using validity, reliability, and normality tests. This study indicates that the quality of productive zakat distribution services has urgency in creating satisfaction for mustahiq, with evidence that the quality of productive zakat distribution services has a positive and significant effect on mustahiq satisfaction. This study contributes to NZA Bengkalis regency in improving service quality and satisfaction of productive zakat mustahiq.
Umělecký styl ve výuce češtiny pro dospělé jinojazyčné mluvčí
Authors: Sachrová Kateřina
Published: November 2021

Hlavním tématem publikace je využití uměleckého funkčního stylu ve výuce českého jazyka, ať už jde o výuku češtiny jako jazyka mateřského, či o výuku češtiny jako cizího, popř. druhého jazyka v českých a zahraničních institucích. Autorka se zaměřila na to, co všechno může v současné době vedle své estetické funkce umělecký styl ve výuce nabídnout.
The Effect of Lateral Position with Head Up 45° on Oxygenation in Pleural Effusion Patients
Authors: Rahmawati Endah Yuliany , Pranggono Emmy H , Priambodo Ayu Prawesti
Published: November 2021

The accumulation of fluid in the pleural cavity will interfere with the restriction process, namely disruption of lung expansion so that the air entering the lungs is less than normal. One of the effects is shortness of breath and a decrease in oxygen saturation. In this case, nursing actions play an important role in inadequate ventilation, namely positioning. The lateral position is one of the recommended positions for patients with unilateral lung disease, one of which is unilateral pleural effusion. Position selection is very important to facilitate adequate breathing, namely one with a head-up of 45°. According to some literature, the 45° head-up position can reduce consumption and maximize lung expansion which will result in greater ventilation. To determine the effect of the lateral position with a head-up 45°on oxygen saturation and respiratory rate in a patient with unilateral pleural effusion at the Dr. H. A. Rotinsulu Lung Hospital Bandung. The research design was a quasi-experimental design with one group pre and post-test design with a sample of 44 people. The sampling technique used consecutive sampling. The results showed that there were differences in median oxygen saturation and respiratory rate before and after the intervention. The results of a comparative study using the Wilcoxon test obtained a p value of 0.0001 (p value<0.05). There is an effect of giving a lateral position with a head-up 45° on increasing oxygen saturation and decreasing respiratory rate. Thus, it is expected for the service unit to establish a lateral position in the direction of the effusion with a head-up of 45°as the operational standard for the management of unilateral pleural effusion impaired oxygenation patients.
Wpływ warunków siedliskowych oraz długotrwałego odłogowania na zmienność genetyczną przytulii czepnej (Galium aparine L.)
Authors: OKOŃ SYLWIA , PODSTAWKA-CHMIELEWSKA ELŻBIETA , NUCIA ALEKSANDRA , KURUS JOANNA , OCIEPA TOMASZ , PACZOS-GRZĘDA EDYTA , KOWALCZYK KRZYSZTOF
Published: November 2021

Odłogowanie i modyfikacje w użytkowaniu gruntów rolnych przyczyniają się do zmian bioróżnorodności. Skutkiem tego zjawiska jest powolny proces sukcesji wtórnej roślinności, prowadzący do zwiększenia ich zmienności genetycznej. Celem pracy było określenie poziomu zróżnicowania genetycznego przytulii czepnej występującej na dwóch różnych siedliskach gruntów odłogowanych. Oceny zróżnicowania genetycznego dokonano, wykorzystując system markerowy ISSR. Na podstawie wyników badań polimorfizmu markerów ISSR utworzono macierz dystansu genetycznego Dice’a. Wartość indeksów podobieństwa wahała się od 0,755 do 1,00. Wykazano niewielką zmienność genetyczną analizowanych genotypów przytulii czepnej. Wspólna klasteryzacja genotypów z poszczególnych siedlisk naturalnych może świadczyć o tym, że typ siedliska, gleba oraz długotrwałe odłogowanie mogą powodować różnicowanie przytulii czepnej.
Wsparcie polskiego rolnictwa ze środków unijnych w latach 2007–2013 na przykładzie powiatu makowskiego
Authors: JAKUBIAK KAMIL , RZYMOWSKA ZOFIA
Published: November 2021

W pracy przedstawiono wyniki analizy wsparcia finansowego działalności rolniczej gospodarstw w powiecie makowskim w ramach PROW 2007–2013. Analizę przeprowadzono na podstawie danych Agencji Restrukturyzacji i Modernizacji Rolnictwa. Od momentu akcesji do Unii Europejskiej w polskim rolnictwie obserwować można liczne zmiany. Integracja z UE umożliwiła korzystanie z różnych instrumentów wsparcia sektora rolnego. Najważniejsze z nich to płatności bezpośrednie, które przysługują rolnikowi aktywnemu zawodowo, posiadającemu grunty rolne. Płatność była przyznawana również do powierzchni upraw konkretnych roślin. Na przestrzeni lat system płatności ewoluował. Wdrażane reformy wprowadzały zmiany w sposobie oraz skali przyznawanych środków finansowych. Oprócz rekompensaty bezpośredniej dla rolników wyszczególnić można inne działania wspierające finansowo gospodarstwa rolne. Poza dopłatami bezpośrednimi rolnicy w analizowanym regionie w największym zakresie skorzystali ze środków na modernizację gospodarstw rolnych oraz z działań ułatwiających start młodym rolnikom.
Международная деятельность субъектов федерации
Authors: Пустогаров В. В.
Published: November 2021

.
ЕЩЕ РАЗ О КОМПЕТЕНЦИИ ЕВРОПЕЙСКИХ СООБЩЕСТВ
Authors: Клёмин А. В.
Published: November 2021

.
СОДРУЖЕСТВО НЕЗАВИСИМЫХ ГОСУ­ДАРСТВ В МИРОПОРЯДКЕ НА ОСНОВЕ ГОСПОДСТВА ПРАВА
Authors: Каламкарян Р. А.
Published: November 2021

.
Preoperative cardiopulmonary exercise testing for risk assessment before elective coronary artery bypass grafting surgery
Authors: Carazza Mariana , Souza Fernando CC , de Lorenzo Andrea Rocha
Published: November 2021

Objective: To evaluate the feasibility and results of performing cardiopulmonary exercise test (CPET) in coronary artery disease (CAD) patients before elective coronary artery bypass grafting surgery (CABG). CPET has been increasingly employed in the evaluation of preoperative risk before noncardiac surgeries, but is still underutilized before cardiac surgery and may be useful, as clinical risk scores for preoperative assessment before cardiac surgeries have several limitations.

Methods: Patients with CAD underwent CPET within 1 week before CABG. Oxygen consumption, oxygen pulse, oxygen consumption at the anaerobic threshold, minute ventilation/carbon dioxide relationship slope (VE/VCO2 slope), oxygen uptake efficiency slope (OUES) and heart rate recovery (HRR) were analyzed. The occurrence of complications during the test was recorded.

Results: Twenty-eight patients (75% men), aged 61 (8) years, underwent preoperative CPET. There were no complications during CPET, even though 71.4% were interrupted by signs or symptoms of ischemia, and only 57% of the patients reached the anaerobic threshold.

 Conclusions: Preoperative CPET before elective CABG was feasible and safe. However, a large proportion of patients did not achieve the anaerobic threshold. Therefore, VE/VCO2 slope, OUES and HRR may be the most useful CPET variables in the preoperative period.

Key words: coronary artery disease, coronary artery bypass grafting, cardiopulmonary exercise test, preoperative assessment