bluuebunny/crossref_metadata_2025 huggingface dataset:
Infecting of decidua in premature labor
Authors: Timoshenkova S. V. , Susloparov L. A. , Ryndin V. A. , Tatarovа N. A. , Timoshenkov A. E. , Lashko M. E.
Published: November 2021

In this work we have studied the changes of decidua in premature labor and analysed the pregnancy, labor, postnatal period and neonatal period in women with infection of decidua. We have obtained existing of certain pathological changes of decidua in 98% of all cases of premature parturition. In this part there were 68% of cases with infectious disorders. And almost always (in 93%) they were accompanied by involutionary-dystrophic and dyscirculatory changes of decidua and disorders of ripening of villi. We have revealed an inflammation with the major forms of localization as damage of decidual membrane, choriodeciduitis, and intervillusitis without major localization under chorial lamina. We have also revealed damage of syncytium and stroma of villi with deposition of maternal leukocytes without involving of villous vessels in inflammatory process. This all is to confirm that the main sources infecting decidua are the foci of infection in pregnant women. Therefore, infectious agents from those foci spread into decidua by haematogenic ways.
Inflammation of parauretral glanduli in women - scineitis
Authors: Gluharev A. G.
Published: November 2021

Having more than 30-years advisory experience of work in polyclinic and carried out the analysis of supervision more than for 500 patients have allowed the authors to solve to some extent the problem of cystalgia - this of poorly investigated pathology, to develop the circuit of diagnostic search at such complaints and to offer the method of treatment giving positive effect up to 60%. In 15 % of cases use of a technique they observed a significant improvement - glanduli inflammation has disappeared, there were only insignificant unpleasant sensations in uretra area. At 10 % intensity of the complaints substantially has decreased, but there were relapses requiring repeated realization of treatment. In 8 % the unsatisfactory result is received and in 17 % - it has remained is unknown.
Professor Pel A.V. - the founder of organotherapy
Authors: Dolgov G. V. , Puga D. P.
Published: November 2021

In the article the basic steps of organotherapy development in Russia are described. The methods, used for drugs production are shown. There is also a historical review of life and work of organotherapy founder A.V. Pel.
The criterion and opportunity of organ-saving operations at purulent- inflammatory diseases of uterus and andex in women of reproductive age
Authors: Bagnenko S. F. , Novikov E. I. , PIakhotnikov I. A. , Kira E. F. , Borisov A. V. , Gorbakova L. Sh.
Published: November 2021

The authors judge, that use of the offered criteria under conditions of highly skilled and specialized hospital makes possible the performance, of mainly less invasive organ-saving operations in women of reproductive age at purulent - inflammatory diseases of uterus and adnex.
The factors of risk of trombophyllia and aterosclerosis: influence of age and reception of estrogen-gestagen OCP's
Authors: Tarasova M. A. , Kobylianskaya V. A.
Published: November 2021

In the article the results of research for mutation of the factor V Leiden, hemostasic parameters estimating internal and external mechanisms of activation of curtailing blood and anticoagulant system, resistance index for this age group has the importance to the activity of the factor VIII are considered. At the women of the senior age, despite of presence in them of initial moderate hyper- and dislipid syndrome on a background of reception of preparations containing progestagen- desogestrel, were observed antiaterogenic change of a lipids spectrum in plasma.
Seismic Constraint on Heterogeneous Deformation and Stress State in the Forearc of the Hikurangi Subduction Zone, New Zealand
Authors: Gosselin Jeremy M. , Audet Pascal , Fry Bill , Warren-Smith Emily
Published: November 2021

The Hikurangi subduction zone (HSZ) is the collisional boundary between the Pacific and Australian tectonic plates along the eastern coast of the North Island of New Zealand. The region is believed to be capable of hosting large megathrust earthquakes and associated tsunamis. Recent studies observe a range of slip behavior along the plate interface, with a sharp contrast between locked and creeping parts of the megathrust along the margin. This work uses teleseismic scattering data (receiver functions [RFs]) recorded at 53 long-running seismograph stations on the North Island of New Zealand to constrain the structure and mechanical properties of the forearc in the HSZ. We observe directional variations in RF phases at P–S converted delay times (i.e., depths) associated with the overlying forearc crust and note a general correlation with spatial variations in plate coupling as well as other geophysical properties. Our results suggest differences in the nature of crustal deformation (and stress state) along the Hikurangi margin, with evidence of clockwise rotation and/or extension in the northern HSZ, where the overriding forearc crust is uncoupled from the subducting Pacific slab.
Marco regulatório da educação superior brasileira
Authors: Peixoto Maria do Carmo de Lacerda , Pinto Jane Cristina da Silva
Published: November 2021

Este artigo discute o marco regulatório da regulação, supervisão e avaliação da educação superior, consolidado no Decreto n. 9.235, de 2017. A análise documental revelou que os atos regulatórios e avaliativos foram simplificados, e a atuação do Estado foi flexibilizada, com a ampliação do escopo das iniciativas a cargo das instituições de educação superior. Além disso, parte dos procedimentos previstos foram remetidos à regulamentação posterior, e ações de supervisão receberam maior detalhamento, explicitando-se as fases desses processos e as medidas cautelares a serem aplicadas pelo poder público.
Ki-67 expression in human oral squamous cell carcinoma
Authors: Kumar Harendra , Chandrakanta  , Nagayach Pooja , Sonkar Ritu , Bharti Rajni
Published: November 2021

Oral cancers are one of the 10 leading cancers in the world. However, in India, it is one of the most common cancers and constitutes a major public health problem. Oral squamous cell carcinoma is a well-known malignancy that accounts for more than 90% of all oral cancers.

The study is carried out on 40 biopsy samples received on oral mucosa, in Department of Pathology of our institute.

Maximum numbers of patients were from 3th to 6th decade in our study. 38 cases of oral squamous cell carcinoma were observed, out of which 31 (81.57%) were male, and 07 (18.42%) cases were female. The most common site was tongue (50%), followed by buccal mucosa (18.42%), 06 patients (15.78%) had lesion at palate. Thirty-five (92.10%) cases had a significant history of tobacco use/smoking, whereas 03 (7.89%) did not have any history of tobacco use. We observed Ki-67 LI for normal oral mucosa was 14 ± 5.6%. In well-differentiated carcinoma, the KI-67 LI was 28.52 ± 21.25%, which increased to 42.85 ± 18.2% in moderately differentiated carcinoma and 68.57 ± 17.6% in poorly differentiated carcinoma.

Ki-67 acts as an excellent marker of cellular proliferation. There is a statistical difference in KI-67 overexpression between various grades of oral squamous cell carcinoma and normal oral mucosa (p value <0.05).
Ki67 and P53 expression in breast cancer and their correlation with clinicopathological parameters
Authors: Gogoi Sukanya , Das Bandita , Borgohain Mondita , Gogoi Gayatri , Das Jayanta
Published: November 2021

Breast carcinoma is the most common malignancy in females and is a leading cause of death. Treatment depends upon various pathological and prognostic markers like lymph node status, size, type and grade of the tumour which influences the outcome of breast cancer. Markers like Ki-67 and p53 have been studied extensively and their roles in breast cancer are yet to be established.We evaluated the expression of Ki67 and P53 in breast cancer and their association with other clinico-pathological factors was studied.

Ki67 and P53 expression was assessed in 60 breast cancer cases admitted to our hospital over a period of one year. Association with other prognostic parameters was evaluated. Statistical analysis was done by Chi square test and a p value of <0.05 was taken as significant.

43.33% cases had low proliferative Ki-67 score whereas 56.67% of the cases were highly proliferative. p53 expression was seen in 41.66% cases. Ki-67 and p53 expression were not significantly related to age, menopausal status, and tumour size whereas a significant correlation was seen with positive axillary lymph node status, high histological grade, negative hormone receptor status (ER, PR) and positive HER2/neu expression. Significant association was seen between Ki-67 and p53 expression.

Ki67 and P53 may be considered as a valuable biomarker in breast cancer patients which can help in planning treatment strategies.
The problem of the social ideal in the philosophy of Boris Chicherin
Authors: Chizhkov Sergey
Published: November 2021

The article analyzes the concept of the ideal of social life, developed by B.N. Chicherin. The first part of the article examines his criticism of various representations of the social ideal in the history of thought and in socio-economic and political concepts contemporary to Chicherin. Special attention is paid to his analysis and criticism of the social ideal of socialist doctrines. The second part of the article is devoted to the analysis of tendencies in liberal thought, controversial from Chicherin's point of view. It provides Chicherin's criticism of the notions of social liberalism emerging at the end of the 19th century. In the third part, an analysis of his own concept is given, Chicherin's ideas about the ways of forming a society based on individual freedom are considered, and the social role of ideas about the social ideal is analyzed.
Diseño de dispositivo mecánico para el traslado de pacientes con discapacidad motriz
Authors: Morales-Pérez Leandro , Caro-Cabezas Jhon , Amador-Cáceres Belkys , García-Caicedo Jesús
Published: November 2021

Las discapacidades físicas y motrices que afectan directamente la movilidad de los miembros inferiores generan dependencia del paciente para su movilización y realización de actividades cotidianas, propiciando en algunos casos sobrecarga en el personal de enfermería y cuidadores, manifestada en problemas musculares, además de riesgos al paciente por condiciones inseguras al momento de hacer las movilizaciones. Para aportar una solución al traslado seguro de pacientes parapléjicos y tetrapléjicos en centros de atención médica, surge esta investigación, cuyo objetivo es diseñar un dispositivo mecánico para el traslado de pacientes con discapacidad motriz en centros hospitalarios. Se utilizó una metodología que incluyó la detección de necesidades desde el usuario directo e indirecto, para luego generar los conceptos, seleccionar la mejor propuesta y realizar el diseño de detalle incluyendo el cálculo y la selección de componentes y el análisis estructural de las piezas críticas. El resultado del proyecto fue el diseño de un dispositivo de apoyo que cumplió con la normativa de seguridad y de diseño establecida, y que brinda seguridad y comodidad tanto al paciente como al cuidador, quien se encargará de la manipulación y traslado.
Comportamiento físico-mecánico del hormigón adicionando residuos de acero: una revisión literaria
Authors: Muñoz-Pérez Socrates Pedro , Cabrera-Alcántara Antonny Luis , Delgado- Bravo Carlos César , Renilla-Lau Paula Alejandra
Published: November 2021

En la actualidad, el interés por usar materiales de desecho y subproductos provenientes del hormigón ha incrementado, debido a la necesidad de minimizar la contaminación en el planeta. El presente documento tiene como objetivo la revisión sistemática de la literatura con respecto a la implementación de los residuos de acero en la mezcla de hormigón, y cómo esto influye en su comportamiento físico-mecánico. Se ha enfocado el interés principalmente en los residuos de acero en forma de escoria, limadura, viruta y fibras, incorporados en todo tipo de hormigón estructural, utilizado en columnas, vigas, zapatas, losas y muros. El uso de estos materiales tiene un alto impacto, pues no solo ayuda a reducir el costo de fabricación de cemento y hormigón, sino que a la vez otorga numerosos beneficios ecológicos, como reducir el costo de los vertederos, ahorrar energía y proteger el medio ambiente de una posible contaminación. Se efectuó la búsqueda de artículos indexados en las diversas bases de datos, tales como ASCE, EBSCO, Google Scholar, ScienceDirect, Scopus y SpringerOpen; se seleccionó finalmente un total de 60 artículos publicados desde el año 2014. Se concluye que el uso de residuos de acero es una alternativa para incorporar a la mezcla de hormigón, pues puede reemplazar parcial o totalmente al agregado y lograr la producción de hormigones que no presenten afección en sus propiedades físico-mecánicas; e incluso, en algunos casos, mejorar dichas características.
Анализ опыта работы по реализации социально-педагогического содействия трудоустройству субъектов образования
Authors: Пак Л.Г. , Каменева Е.Г. Е.Г. , Кочемасова Л.А. , Енина К.С.
Published: November 2021

В статье рассматривается анализ опыта по реализации социально-педагогического содействия трудоустройству выпускников высших учебных заведений. Охарактеризована деятельность Региональных центров содействия трудоустройству выпускников вузов, осуществляющих комплексную подготовку студентов к выходу на рынок труда для успешного начала трудовой деятельности.
Effect of Sleep Restriction on Cardiometabolic and Haemoinflammatory Parameters in Adult Male Wistar Rats
Authors: Dissi Gambo Mahdi , Ibrahim Salisu Ahmed , Tanko Yusuf , Aliyu Mohammed
Published: November 2021

Background and Objective: While insufficient sleep remains an under-recognized public health issue across the globe, there is paucity and heterogeneity of data regarding its cardiometabolic and haemoinflammatory implications. We, therefore, aimed to evaluate the impact of chronic sleep restriction on cardiometabolic and haemoinflammatory parameters in rats.
Materials and Methods: 16 male Wistar rats (aged 8-10 weeks) were randomly assigned into equal control or sleep restriction groups. Gentle handling was used to induce sleep restriction for six weeks. Fasting weight and blood sugar were obtained and lipids were analyzed using their respective Randox kits. Malondialdehyde (MDA) levels and catalase (CAT) and superoxide dismutase (SOD) activities were assayed. Full blood count and CD4+ T cell count were determined using automated analyzer. Data were analyzed using Student’s t-test, with level of significance set at P ≤ 0.05, via SPSS software.
Results: Chronic sleep restriction caused significant initial weight loss, increase in feed consumption, and percentage increase in fasting blood sugar (FBS) (32% vs. 15%). We also noted the triglyceride-glucose (TyG) index of sleep-restricted rats to be significantly higher (6.22) than that of controls (5.62). In addition, a significant reduction in monocyte count, monocyte-lymphocyte ratio (MLR), and absolute CD4+ cell count among the sleep-restricted rats was observed.
Conclusion: Our findings have provided objective evidence that, over the course of 6 weeks, 5 hours of sleep restriction had caused body weight gain, hyperglycaemia, insulin resistance, and impairment in immunoinflammatory status; hence, it could be a risk factor for developing cardiometabolic syndrome and immune-related disorders.
Sleep Quality Components as Predictors of Health-Related Quality of Life Domains among Primigravida in Ibadan, Nigeria
Authors: Bosede Olutola Funmilola , A. Adejuwon Grace
Published: November 2021

Background and Objective: Pregnancy and childbirth are periods of great joy and delicate, interesting, and exciting aspects of women’s life. The study investigates whether sleep quality components will predict health-related quality of life (HRQOL) domains among primigravidas.
Materials and Methods: The study employed descriptive research design. 768 primigravidas, attending antenatal care in nine purposively-selected government hospitals in Ibadan, Nigeria, which fulfilled the inclusion criteria participated in the study. A questionnaire consisting of demographic information of primigravidas, World Health Organization Quality of Life-BREF (WHOQOL-BREF), and Pittsburgh Sleep Quality Index (PSQI) with reliability coefficient of 0.89 and 0.85, respectively, were used to collect data. Six hypotheses were tested using multiple regression analysis (MRA) and analysis of variance (ANOVA).
Results: Sleep quality components had a statistical, joint influence on HRQOL domains (physical health domain, F = 4.526, P < 0.01; psychological domain, F = 2.931, P < 0.05; and environment domain, F = 2.788, P < 0.05) of primigravidas in Ibadan. In addition, domains of HRQOL were significantly influenced by primigravidas’ marital status (F = 3.591, P < 0.05).
Conclusion: Effective management of sleep quality components during pregnancy can improve HRQOL domains of primigravidas. Researchers recommended that antenatal care lectures for primigravidas should be reinforced with emphasis on the sleep quality and its influence on their HRQOL domains for better wellness of the primigravidas.
Excessive Blood Glucose in Diabetic Ketoacidosis and Hyperosmolar Hyperglycemia: A Rare Case Report
Authors: Kashanizadeh Alireza , Salmanpour Ahmad Reza , Sahrae Nasim Shirin , Firoozbakht Mohammad , Karimi Hamid
Published: November 2021

Type 1 diabetes (T1D) is an autoimmune assault on pancreatic β-cells characterized by a decrease in insulin production. The worldwide incidence rate of T1D is reportedly increasing. In parallel with the increase of T1D, diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) also appear as two risk factors for hyperglycemia. This case report presents a T1D patient with DKA and HHS who was finally discharged after recovery.
Cooperativismo agropecuario en Argentina: antecedentes y transformaciones
Authors: Verbeke Griselda
Published: November 2021

Las cooperativas del sector agropecuario surgieron en Argentina, hacia fines del siglo XIX, como organizaciones que integraron a pequeños y medianos agricultores en torno a la producción del sector, para convertirse luego en una rama significativa del movimiento cooperativo nacional. Las transformaciones de índole económica, política y organizacional que las afectaron en su evolución, se han reflejado en la fuerte contracción del número de entidades y en cambios importantes en la configuración de su perfil socio productivo. A la luz de esas transformaciones, este artículo se propone caracterizar la estructura y dinámica actual del sector.

Recibido: 23 junio 2021Aceptado: 17 septiembre 2021
“My Monster Self”: Violence and Survival in Margaret Atwood’s Moral Disorder
Authors: Fakhrshafaie Nahid , Bahremand Alireza
Published: November 2021

Margaret Atwood’s novels are usually celebrated for their blunt feminism. However, in Moral Disorder—a series of interconnected stories that forms a novel—feminist concerns are replaced with worries about territory and survival. The protagonist is an insider whose sole concern is to survive and to protect her territory. The confrontation between the narrator as the insider and the outsiders does not occur directly but could be inferred by her cruelty toward other characters and her violence against the animals under her care. The present study argues that this cruelty, which abounds in the novel, could be viewed as a substitute for violence against the outsiders. The narrator’s gaze at the Indian boy who entered the protagonist’s territory manifests a garrison mentality. The frequent references to axes in the novel are compared to the use of axes in “Wilderness Tips,” a short story by Atwood in which axes also have a metaphoric significance. The beheading and dismemberment of domestic animals could be the punishment awaiting the intruder. The novel establishes a division between the insider/outsider, here/there, self/other and civilized/barbaric to call for action and awareness about the importance of protecting one’s territory.
Caracterización de la distribución de viajes en el distrito de San Borja como plataforma de datos para futuras propuestas de gestión de tráfico
Authors:   , Melgarejo Rojas, Albert Jhosep , Damian Delgado George Edwar
Published: November 2021

El distrito de San Borja, es actualmente, uno de los lugares más congestionados en la provincia de Lima. Por ello, es importante realizar estudios que reflejen la situación actual del distrito y, así mismo, poder dar solución a los puntos con mayor tráfico vehicular. El distrito de San Borja, no cuenta con una base de datos actualizada con dicha información, por lo cual esta tesis propone una plataforma de base de datos que identifique los principales orígenes y destinos de los viajes, obtenida mediante encuestas en el distrito de San Borja, el cual será el área de estudio para esta investigación. Esta área de investigación se ha dividido convenientemente en 12 zonas, las cuales se ha hecho coincidir con los 12 sectores en los cuales se encuentra dividido el distrito de San Borja, con el objetivo de aprovechar la disponibilidad de datos referidos a esa zonificación. Además de ello, se ha tomado en cuenta 4 macro zonas externas adicionales (conformadas por los distritos restantes en la provincia de Lima), es decir, en total 16 zonas de estudio. Con los datos procesados, se obtuvo una matriz Origen Destino actual, la cual se calibró mediante dos modelos (Gravitacional y Fratar) de distribución de viajes, los cuales se utilizaron para el pronóstico de un escenario futuro proyectado a 5 años. Previamente, se elaboraron los modelos de generación y atracción de viajes, los cuales son requisitos para los modelos de distribución de viajes.
Caracterización de la distribución de viajes en el distrito de San Borja como plataforma de datos para futuras propuestas de gestión de tráfico
Authors:   , Melgarejo Rojas Albert Jhosep , Damian Delgado George Edwar
Published: November 2021

El distrito de San Borja, es actualmente, uno de los lugares más congestionados en la provincia de Lima. Por ello, es importante realizar estudios que reflejen la situación actual del distrito y, así mismo, poder dar solución a los puntos con mayor tráfico vehicular. El distrito de San Borja, no cuenta con una base de datos actualizada con dicha información, por lo cual esta tesis propone una plataforma de base de datos que identifique los principales orígenes y destinos de los viajes, obtenida mediante encuestas en el distrito de San Borja, el cual será el área de estudio para esta investigación. Esta área de investigación se ha dividido convenientemente en 12 zonas, las cuales se ha hecho coincidir con los 12 sectores en los cuales se encuentra dividido el distrito de San Borja, con el objetivo de aprovechar la disponibilidad de datos referidos a esa zonificación. Además de ello, se ha tomado en cuenta 4 macro zonas externas adicionales (conformadas por los distritos restantes en la provincia de Lima), es decir, en total 16 zonas de estudio. Con los datos procesados, se obtuvo una matriz Origen Destino actual, la cual se calibró mediante dos modelos (Gravitacional y Fratar) de distribución de viajes, los cuales se utilizaron para el pronóstico de un escenario futuro proyectado a 5 años. Previamente, se elaboraron los modelos de generación y atracción de viajes, los cuales son requisitos para los modelos de distribución de viajes.
The vehicle driver safety prediction system
Authors: Wróbel Radosław , Sierzputowski Gustaw , Haller Piotr , Mihaylov Veselin , Dimitrov Radostin
Published: November 2021

The article presents analysis of road crash accidents. It presents the evolution of safety systems, starting from a description of the curently used vehicle-based systems, with particular emphasis on the prediction of the driver falling asleep. The article also proposes a proprietary system of sleep prediction based on the face detection of drivers. The detection of facial landmarks is presented as a two-step process: an algorithm finds faces in general, and then needs to localize key facial structures within the face region of interest. The article presents the operation of the algorithm to detect driver falling asleep; method of detection and analysis.
Сhronic pain syndrome, risk factors for its development at stage of operative intervention
Authors:   Tver State Medical University, Morozov A.M. , Sergeev A.N. ,   Tver State Medical University, Kadykov V.A. ,   Tver State Medical University, Zhukov S.V. ,   Tver State Medical University, Minakova Yu.E. ,   Tver State Medical University, Pichugova A.N. ,   Tver State Medical University, Belyak M.A. ,   Tver State Medical University
Published: November 2021

At the present time, approximately 80% patients experience postoperative pain which is the leading entity in the overall structure of chronic pain. The aim of this article is investigation of reasons and risk factors underlying its development. Based on the information provided in domestic and international sources in open databases, analysis of these problems has been carried out. Selection of adequate therapy is particularly important against the background of the need for long-term intake of strong analgesics or the impossibility of pain management due to the neurogenic aetiology of the disease. In this connection, it is necessary to study factors predisposing patients to development of chronic postoperative pain and resort to prevention measures in order to reduce the risk of pain syndrome development.
Problemas escolares, medicalização e singularidades de adolescentes
Authors: Fonseca Luciana Renata Moreira , Assis Raquel Martins de , Santiago Ana Lydia Bezerra
Published: November 2021

O presente artigo descreve os resultados de uma pesquisa/intervenção de orientação psicanalítica por meio do relato de um estudo de caso de uma aluna do Ensino Fundamental de uma escola pública da rede estadual de ensino da cidade de Itabira-MG. A estudante apresentava várias dificuldades de aprendizagem e impasses na esfera escolar, enfrentados por meio do processo de medicalização. Contrapondo-se à medicalização, o caso visa demonstrar a contribuição de um dos procedimentos adotados nessa pesquisa: o Diagnóstico Clínico-Pedagógico (DCP), cuja intervenção realiza a leitura daquilo que a criança ensina ao educador sobre sua singularidade e sobre as particularidades que se repercutem na sua relação com o saber e com os laços sociais engendrados na escola. Os resultados obtidos por meio do DCP permitiram perceber o impacto do fenômeno da adolescência nas relações com o saber escolar e a possibilidade de utilizar abordagens teóricas e práticas que permitam aos sujeitos agir sobre os seus problemas. 
Palavras-chave: Psicanálise. Dificuldades de aprendizagem. Medicalização. Adolescência. Educação.
Perioperative complications of the modified Stoppa approach for the treatment of pelvic bone fractures: a single-institution review of 48 cases
Authors: Lee Hyeonjoon , Jo Suenghwan , Lee Gwangchul , Cho Yongjin
Published: November 2021

Purpose: The current study aimed to report the perioperative complications of the modified Stoppa approach for the treatment of pelvic bone fractures. Methods: We analyzed 48 consecutive operations in 45 patients who were treated with internal fixation using the modified Stoppa approach between March 2016 and July 2018. This included three revision operations. The mean age of the patients was 54.5 years, and the patients included 35 male patients and 10 female patients. All fractures occurred as a consequence of high-energy trauma and 70.3% had associated injuries at the time of the fracture. The mean Injury Severity Score was 9.03±5.60. The perioperative complications found during and immediately after surgery were recorded and were classified into three categories: vascular injuries, nerve injuries, and other complications. Results: Overall, 14 perioperative complications (29.2%) in 14 cases were identified. The most common complications were nerve injuries, which occurred in seven cases, all involving the obturator nerve. Uncontrollable vascular injuries occurred in six cases, which required additional incisions and support of vascular surgeons or postoperative interventions. Additionally, one case of peritoneal tearing occurred, which required help from an abdominal surgeon. Conclusions: While the modified Stoppa approach seems to be a viable method to treat pelvic fractures, significant perioperative complications may occur, suggesting that surgeons should pay careful attention to minimize the damage to other structures and that appropriate support from other surgical departments is paramount.
CORRELATION BETWEEN ENVIRONMENTAL FACTORS AND THE HUMAN DEVELOPMENT INDEX IN EAST JAVA IN 2019
Authors: Firdaus Nadiyah , Adnan Airil Haimi Mohd
Published: November 2021

Public health is influenced by environmental factors. The success of public health development can be seen from the Human Development Index (HDI). This research aims to analyze the relationship between environmental factors and the HDI in East Java in 2019. This research analyzed secondary data obtained from the East Java Provincial Health Office and published on the website of the Central Bureau of Statistics. Health Profile data in 2018 and the Human Development Index data in 2019 were used. This study used total sampling and selected all districts/cities in East Java (38 districts/cities). The Shapiro Wilk test (a sample of less than 50) was chosen to analyze the normality of the data and a Pearson correlation test was conducted to investigate the relationship between each variable. Based on our Pearson correlation analysis, we found several relationships between each variable. This study found that there is a relationship between access to decent drinking water and the HDI, as well as qualified latrines with the HDI, both with p-values of 0.000. Relationships were also found for healthy homes with the HDI with the p-value of 0.004, as well as qualified public places with the HDI with the p-value of 0.003. Finally, we found that there was no relationship between decent drinking water quality the HDI with a p-value of 0.821.
SIDE EFFECTS OF INJECTABLE AND ORAL CONTRACEPTIVE AND UNINTENDED PREGNANCY AMONG REPRODUCTIVE WOMEN IN INDONESIA
Authors: Gayatri Maria , Irawaty Dian Kristiani
Published: November 2021

Using contraception is essential for protecting women from the risk of unintended pregnancy. However, contraceptive discontinuation, caused by side effects of contraceptives or health problems, is still high. This study aimed to assess the impact of injectable and pill contraception discontinuation due to side effects or health problems on unintended pregnancy among women aged 15-49 years in Indonesia. This study is based on the 2017 Indonesia Demographic and Health Survey. As many as 1,613 women who discontinued their oral contraceptives and 5,022 women who discontinued their injectables were followed retrospectively. Pregnancy rates were tested for differences between categories using survival analysis. It was found that one year after stopping contraceptives due to side effects, almost 16-17% of oral/injectable contraceptive users were already pregnant. The pregnancy rate was higher among women aged less than 25 years. Unplanned pregnancy occurred more frequently among women who were not working than women who were working. Counseling services need to be strengthened by improving provider knowledge and skills to give comprehensive information including contraceptives’ side effects.
OPTIONS OF LONG-TERM CONTRACEPTIVE METHODS IN MARRIED WOMEN IN SOUTH SULAWESI (ANALYSIS OF IDHS 2017)
Authors: Azis Rahmawati , Mahmud Akmal , Arsyad Syahmida Syahbuddin
Published: November 2021

The long-term contraceptive method is an effective method for preventing pregnancies. However, users of long-term contraceptive methods are considerably lower compared to those of non-long-term contraceptive methods in South Sulawesi. The research objective was to examine the determinants of choosing long-term contraceptive methods in South Sulawesi. This study used data from the 2017 Indonesia Demographic and Health Survey by analyzing 583 married women who were using contraception in South Sulawesi. A descriptive analysis was employed to estimate the prevalence of long-term contraceptive methods. Meanwhile, the Chi-square test and logistic regression analysis were used to identify the determinants of choosing long-term contraceptive methods. The results from the descriptive analysis showed about 18.9% of the sampled married women were long-term contraception users, among those were implant users (10.2%). More married women with higher education and more parity chose to use it. The better the knowledge about the type of contraception, the greater the chance to use long-term contraceptive methods. Women who were told about side effects, sources of government services, and free fees were significantly influenced to use long-term contraception. Women who received staff visits and visited health facilities were less likely to choose the long-term methods. This implies that contact with field oMKJPlong-term contraceptive methodslong-term contraceptive methodsfficers has not been able to motivate prospective acceptors to use . Improved education and knowledge, especially about types of contraception and side effects, are needed to increase women’s long-term contraception use alongside. The quality of services at free/subsidized costs also needs to be improved, and training should be given for capacity building, especially in communication skills, to family planning field officers.
Recovery of Haemal Lordosis in European Sea Bass Dicentrarchus labrax (Linnaeus 1758)
Authors: Fragkoulis Stephanos , Kourkouta Chara , Geladakis George , Printzi Alice , Glaropoulos Alexis , Koumoundouros George
Published: November 2021

The lordosis of the haemal part of the vertebral column is a frequent abnormality in reared fish. Haemal lordosis develops during the late larval and early juvenile period, mainly due to the high swimming activity of the fish in the rearing tanks. In the present study we examined whether haemal lordosis recovers during the growth of European sea bass. Furthermore, we aimed to develop simple morphometric indices (PrAn1 and PrAn2) that could link the severity of lordosis at the juvenile stage with fish morphological quality at harvesting. At 111 days post-hatching (dph, 53±4 mm standard length, SL), 600 seabass juveniles with lordotic (L, 200 fish) or normal (N, 400 fish) external morphology were selected and introduced in a common tank. At 150 dph (75±7 mm SL), 350 fish were randomly selected, pit-tagged and transferred in a sea cage for on-growing up to 502 dph (234±16 mm SL). The morphological examination of the fish at 150 and 502 dph revealed that the 60% (46 out of 77) of L juveniles turned into normal phenotype by the end of on-growing period. Interestingly, 56% of the fish with recovered external morphology (N-Rec) presented either a completely normal vertebral column (31%) or minor abnormalities of individual vertebrae (25%). Following the results of geometric morphometric analysis, the differences in the body shape between N-Rec and N fish were not significant (p>0.05, canonical variate analysis). The examined morphometric indices were effective in discriminating the normal fish from the 58% (PrAn1) to 65% (PrAn2) of lordotic juveniles. Results are discussed with respect to the mechanism of lordosis recovery, as well as to their application for the quality control and cull out of the abnormal fish in the commercial hatcheries.
Квазигидродинамический алгоритм в задаче моделирования аттракторов внутренних волн
Authors: Рязанов Даниил Александрович , Ryazanov Daniil Aleksandrovich
Published: November 2021

На примере задачи моделирования волновых аттракторов в стратифицированной
жидкости демонстрируются преимущества квазигазодинамического алгоритма
(QHDFoam) перед классическим алгоритмом расщепления операторов (PISO). Оба
алгоритма реализованы методом конечного объема на базе программного пакета
OpenFOAM с открытым исходным кодом. Показано, что применение алгоритма
PISO не воспроизводит динамику многократного отражения и фокусировки внутренних волн в стратифицированной жидкости во время взаимодействия с границами расчетной области. QHDFoam алгоритм, основанный на решении регуляризованных уравнений
Навье-Стокса, дает результаты, близкие к данным спектрально-элементного метода высокого порядка, данные которого в этой работе считаются эталонными.
Математическая модель оценки информационного воздействия на электорат в социальных медиа при проведении выборных кампаний
Authors: Полянский Иван Сергеевич , Polyanskii Ivan Sergeyevich , Логинов К О , Loginov K O , Ильин Николай Иванович , Il'in Nilolai Ivanovich , Великих Александр Сергеевич , Velikikh Aleksandr Sergeevich
Published: November 2021

Разработана математическая модель оценки информационного воздействия на электорат в социальных медиа при проведении выборных кампаний. Она основана на
известных математических моделях информационного противоборства в структурированном социуме и отличается от них учетом стохастического характера в отношении интенсивностей распространения информации от внешних источников.
Итоговая модель сведена к системе стохастических дифференциальных уравнений,
понимаемой в смысле Ито. Оценка числа адептов и предадептов, отдающих в ходе
выборной кампании предпочтения кандидату, задана выборочным средним, которое вычисляется определяемой из решения уравнения Фоккера--Планка--Колмогорова функцией плотности вероятности. Решение уравнения Фоккера--Планка--Колмогорова выполнено по предложенной численной схеме, основанной на проекционной постановке метода Галeркина. Приведены результаты моделирования в отношении тестовой задачи.
Does Total Hip Arthroplasty Influence the Development and Localization of Sacral Insufficiency Fractures?
Authors: Graul Isabel , Strube Patrick , Vogt Sophia , Matziolis Georg , Brodt Steffen , Hölzl Alexander
Published: November 2021

Background:

Sacral insufficiency fractures (SIFs) are fractures related to reduced bone strength. In a previous study, we noticed that many patients with SIF had undergone total hip arthroplasty (THA). Therefore, the purpose of the present study was to research the localization of clinically apparent SIFs in relation to unilateral THA as well as the influence of unilateral THA on bone mineral density changes in the sacrum.

Methods:

In this retrospective study, 171 patients with SIFs were screened for unilateral THA. In the group of patients with SIF and THA, the rate of SIF ipsilateral and contralateral to the side of the THA was determined. In a second cohort of 39 THA patients with healthy bone, changes in bone mineral density at the sacral alae ipsilateral and contralateral to the THA were analyzed by use of computed tomography immediately postoperatively and at the 1-year follow-up.

Results:

Of the 171 patients with SIF, 50 (40 female; mean age, 79 years; range, 54 to 101 years) were previously treated with THA. Of the 50, 31 patients were treated with unilateral THA. The proportion of patients with an SIF contralateral to the THA was 42% (13 of 31) and ipsilateral to the THA was 19% (6 of 31). Twelve patients had bilateral SIFs. The mean age of the THA group without SIF was 62 years (range, 49 to 79 years); 17 were female. The median bone mineral density decreased significantly (p = 0.023), from 35.0 to 13.0 HU, at the sacral ala contralateral to the THA, whereas the decrease of ipsilateral bone mineral density, from 24.0 to 17.0 HU, was not significant (p = 0.361).

Conclusions:

The proportion of patients with an SIF contralateral to a THA was twice as high as that of patients with an SIF ipsilateral to a THA. These findings are supported by the second cohort’s decrease in bone mineral density at the sacral ala contralateral to the THA at 1 year after surgery. We conclude that THA can lead to spatially different remodeling of the sacrum, possibly affecting the development of SIFs.

Level of Evidence:

Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
A Manipulator Control Method Based on Deep Deterministic Policy Gradient with Parameter Noise
Authors: Zhang Haifei , Jian Xu , Lei Liting , Wu Fang , Qian Lanmei , Qiu Jianlin
Published: November 2021

Focusing on the motion control problem of two link manipulator, a manipulator control approach based on deep deterministic policy gradient with parameter noise is proposed. Firstly, the manipulator simulation environment is built. And then the three deep reinforcement learning models named the deep deterministic policy gradient (DDPG), asynchronous advantage actor-critical (A3C) and distributed proximal policy optimization (DPPO) are established for training according to the target setting, state variables and reward & punishment mechanism of the environment model. Finally the motion control of two link manipulator is realized. After comparing and analyzing the three models, the DDPG approach based on parameter noise is proposed for further research to improve its applicability, so as to cut down the debugging time of the manipulator model and reach the goal smoothly. The experimental results indicate that the DDPG approach based on parameter noise can control the motion of two link manipulator effectively. The convergence speed of the control model is significantly promoted and the stability after convergence is improved. In comparison with the traditional control approach, the DDPG control approach based on parameter noise has higher efficiency and stronger applicability.
Changes in the Mental Health Status of Frail and Pre-Frail Older Adults Over a 1-year Period
Authors: Lai Claudia K. Y. , Liu Justina Y. W. , Cheung Daphne S. K. , Chin Kenny C. W. , Tse Mimi M. Y.
Published: November 2021

Background

This prospective observational study examined changes in the mental health status of frail and pre-frail older adults over a 1-year period, a topic lacking in-depth exploration in the literature.
Method

Fried Frailty Index was used to differentiate frailty status in participants recruited from community centres and residential care facilities in Hong Kong. Demographic and clinical data were collected using face-to-face interview at baseline and repeated after 12 months.
Results

Physical functioning, comorbidities, and psychological and environment domains (World Health Organization Quality of Life instrument) impacted the cognitive functioning, depressive symptoms, and sense of loneliness in the sample (N=107). Functional health and vision had a significant impact on cognitive status; depression negatively associated with comorbidity, functional health, and quality of life domains (psychological and environment); loneliness was affected by both age and environment.
Conclusion

The findings showed that frail and pre-frail older adults have complex needs in relation to their mental health even just over a 1-year period. Intervention programs on frailty that focus on physical aspects will not suffice. Programs for frailty also need to incorporate mental health components to enhance health and wellbeing.
Determination of Hormone Receptors, Human Epidermal Growth Factor Receptor 2 and Ki67 Status in Invasive Breast Carcinoma: A Concordance Study between Immunohistochemistry, Fluorescence in Situ Hybridization, and GeneXpert® Breast Cancer STRAT4 Assay
Authors: elaje rajaa , Naya Abdellah , KHOAJA Ayoub , Zaid Younes , Oudghiri Mounia , Weidler Jodi , Karkouri Mehdi
Published: November 2021

BackgroundThe accurate assessment of hormone receptors (ER and PR), HER2 and Ki-67 proliferative index provides meaningful information about breast cancer prognosis and prediction of therapy response. Immunohistochemistry, the most common method for evaluating these prognostic biomarkers, can be impacted by numerous variabilities due to pre-analytical/analytical factors and subjective interpretation by pathologists. The Xpert® Breast Cancer STRAT4, a RT-qPCR based system, can be used to classify breast invasive carcinomas based on the assessment of these 4 biomarkers. In this study, we investigated the accuracy of RT-qPCR based mRNA expression levels in a closed, single-use cartridge, automated system compared with the current gold standard, immunohistochemistry (IHC), and fluorescent in situ hybridization (FISH) for HER2 equivocal cases.Methods We evaluated ESR1, PGR, ERBB2 and MKi67 mRNA expression by Xpert Breast Cancer STRAT4 and ER, PR, HER2 and Ki67 by IHC (FISH for HER2 IHC 2+) in 200 formalin-fixed paraffin-embedded (FFPE) tissue blocks with invasive breast cancer, collected from the Pathology Department of Casablanca Ibn Rochd University Hospital.Results Concordance between Xpert ® Breast Cancer STRAT4 and IHC was 93.5% for ER, 83.51% for PR, 95% for HER2 (92% for IHC+FISH), and 81.20% for Ki67 (excluding intermediate IHC Staining 10 ≤ %IHC <20). The simple Kappa coefficient was, for ER, 0.830 (P < 0, 0001), 0.565 (P < 0, 0001) for PR, 0.838 (P < 0, 0001) for HER2-IHC, 0.771 (P< 0, 0001) for HER2 IHC+FISH and, for, Ki67, 0.458 (P < 0, 0001).Conclusions We demonstrated globally a high concordance between centrally assessed IHC, IHC+FISH and mRNA measurements of ER/ESR1 and HER2/ERBB2, and a moderate agreement between PR/PGR and Ki67/MKi67. These findings provide an additional, objective, and quantitative assessment of tumor receptor status in breast cancer.
White Blood Cells (WBC) Images Classification Using CNN-Based Networks
Authors: Jung Changhun , Abuhamad Mohammed , Mohaisen David , Han Kyungja , Nyang DaeHun
Published: November 2021

Background: Computer-aided methods for analyzing white blood cells (WBC) are popular due to the complexity of the manual alternatives. Recent works have shown highly accurate segmentation and detection of white blood cells from microscopic blood images. However, the classification of the observed cells is still a challenge, in part due to the distribution of the five types that affect the condition of the immune system.Methods: (i) This work proposes W-Net, a CNN-based method for WBC classification. We evaluate W-Net on a real-world large-scale dataset that includes 6,562 real images of the five WBC types. (ii) For further benefits, we generate synthetic WBC images using Generative Adversarial Network to be used for education and research purposes through sharing.Results: (i) W-Net achieves an average accuracy of 97%. In comparison to state-of-the-art methods in the field of WBC classification, we show that W-Net outperforms other CNN- and RNN-based model architectures. Moreover, we show the benefits of using pre-trained W-Net in a transfer learning context when fine-tuned to specific task or accommodating another dataset. (ii) The synthetic WBC images are confirmed by experiments and a domain expert to have a high degree of similarity to the original images. The pre-trained W-Net and the generated WBC dataset are available for the community to facilitate reproducibility and follow up research work.Conclusion: This work proposed W-Net, a CNN-based architecture with a small number of layers, to accurately classify the five WBC types. We evaluated W-Net on a real-world large-scale dataset and addressed several challenges such as the transfer learning property and the class imbalance. W-Net achieved an average classification accuracy of 97%. We synthesized a dataset of new WBC image samples using DCGAN, which we released to the public for education and research purposes.