bluuebunny/crossref_metadata_2025 huggingface dataset:
Poor Oral Health-Related Quality of Life in Pre- and Post-Liver Transplantation Patients
Authors: Santos-Lins Larissa S. , Aguiar Inácio L.S. , Codes Liana , Evangelista Maria A. , de Oliveira Castro Alessandra , L. Bittencourt Paulo , Cavalcanti Andrea , Paraná Raymundo , Lins-Kusterer Liliane
Published: May 2021

Background:

Oral health is associated with Chronic Liver Disease (CLD) and may play a relevant role in oral (OHRQoL) and general health-related quality of life (HRQoL) among people with chronic liver disease (CLD).

Objective:

To explore the correlations between OHRQoL and HRQoL in pre- and post-liver transplantation (LT) patients.

Methods:

A cross-sectional study with 189 patients: 63 per group (pre-LT, post-LT, and without liver disease). The Oral Health Impact Profile-14 (OHIP-14), the 36-Item Short-Form Health Survey, and the Work Ability Index (WAI) were used to measure oral health-related quality of life, health-related quality of life, and work ability, respectively. Oral health was evaluated according to the World Health Organization criteria. The relationship between the OHIP-14 and independent variables was analysed by multiple linear regression.

Results:

Pre-LT group presented the highest OHIP-14 total mean score, followed by the post-LT group, compared to the group without liver disease (p=0.001). All HRQoL and WAI mean scores were lower in the pre-LT group than in the other groups (p≤0.013). In the pre-LT group, the OHIP-14 total mean score was negatively correlated with the Mental Health, Physical Functioning, and General Health mean scores (p=0.01) and negatively and significantly (p<0.05) associated with decayed teeth and with poor workability. In the post-TL group, OHRQOL of life was associated with decayed and missing teeth, lower educational level, and poor workability.

Conclusion:

Patients in the pre- and post-LT groups presented poorer OHRQoL compared to patients without liver disease. OHRQoL was strongly correlated with HRQoL in the pre-LT group.
Efficacy of MTA Modified by Nanosilver for the Prevention of Coronal Leakage
Authors: Nasri Shifteh , Afkhami Farzaneh
Published: May 2021

Background:

Numerous materials have been introduced as coronal barriers, however, they have shown various degrees of microleakage. Therefore, attempts are undertaken to introduce more reliable materials with the potential to provide a long-term coronal seal.

Introduction:

Thisin vitrostudy aimed to assess the efficacy of gray ProRoot Mineral Trioxide Aggregate (MTA) modified by a suspension of silver nanoparticles (AgNPs) as an orifice plug using a bacterial leakage method.

Methods:

40 extracted human teeth were prepared and filled (except for the negative control group) using the lateral compaction technique. The coronal 2 mm of the root filling was removed in the experimental groups. The teeth were randomly divided into two experimental (n = 15) and two control (n = 5) groups. In the experimental group 1 (MTA group) and the experimental group 2 (Ag-MTA group), MTA modified by a suspension of AgNPs was used as an orifice plug. In the negative control group, the entire root surfaces were covered with two layers of nail varnish. In the positive control group, the root canals were filled with a single gutta-percha cone without a sealer and no orifice plug. Bacterial leakage was assessed using a two-chamber system. The teeth were incubated at 37°C and 100% humidity for 120 days, and human saliva was added to the samples every 3 days. Bacterial microleakage was assessed by daily monitoring and observating the turbidity of the Brain Heart Infusion (BHI) broth. The data were analyzed using the log-rank test.

Results:

All positive controls showed contamination after 5 days. None of the negative controls were contaminated during the experiment. The Ag-MTA group demonstrated a significantly better coronal seal than the MTA group (p = 0.031).

Conclusion:

Gray ProRoot MTA modified by AgNPs has the potential for being used as an orifice plug in endodontically treated teeth.
Assessment of Coronavirus in the Conjunctival Tears in Pediatric Patients with Asymptomatic COVID-19 Infection in Sohag Government, Egypt
Authors: Mahmoud Hany , Radwan Ahmed , El Rashidy Amr , Hefny Hesham M. , Ali Amal H. , Mounir Amr
Published: May 2021

Objective:

The present study aims to evaluate coronavirus shedding in the tears of asymptomatic pediatric COVID-19 positive patients.

Methods:

A prospective interventional study that included a total of 145 pediatric asymptomatic COVID-19 patients hospitalized from 17th May 2020 to 16th July 2020 in Sohag Tropical Hospital. On admission, all of them were COVID-19 positive detected through nasopharyngeal swab. They were in intimate contact with positive symptomatic COVID-19 patients before testing and admission. Reverse Transcriptase Polymerase chain reaction (RT-PCR) was done for tears samples at an interval of 5 days after admission and twice before discharge.

Results:

Of the 145 asymptomatic pediatric COVID-19 positive patients, no one showed ocular or systemic manifestations. They were silent carriers. Ten were positive for tears sample on admission. They became negative for nasopharyngeal and tear samples before discharge.

Conclusion:

Pediatric positive COVID-19 patients can shed coronavirus through their tears. Even among asymptomatic patients, transmission through tears is possible.
Evaluasi Blok Tegangan Tekan Ekuivalen Balok Beton Bertulang Agregat Limbah Batu Onyx Tulungagung
Authors:   Universitas Brawijaya Malang, Asukmajaya R. Bobby , Wahjuni S. Edhi ,   Universitas Brawijaya Malang, Wisnumurti Wisnumurti ,   Universitas Brawijaya Malang
Published: May 2021

Normal aggregate replacement to the onyx waste aggregate will certainly make the compressive strength and modulus of elasticity different, so it will affect the value of the compressive stress block equivalent (β1) as a result of the extent of the changing stress strain curve. In this study, trying to compare between the experimental β1 value of onyx concrete, while analytically the β1 value for normal concrete was obtained in accordance with SNI 2847 - 2019. To get the experimental β1 value from onyx concrete, it is made by looking for the compressive strength, elastic modulus and ꜫ0, for later the stress strain curve of the concrete is made to find the experimental β1 value of the onyx concrete. The results were obtained if the average β1 value of 18 specimens of onyx coarse aggregate concrete with an average compressive strength of 32.92 MPa was 0.868 while the analytical β1 value based on SNI 2847-2019 was 0.839, This shows that the B1 value for concrete with other aggregates is different, so it needs to be checked experimentally.
AJUSTE PSICOLO?GICO EMOCIONAL EN LA POBLACIO?N INFANTO JUVENIL EN SITUACIO?N DE CONFLICTO SOCIAL, UNA APROXIMACIO?N A LOS ESTILOS DE AFRONTAMIENTO PERSONAL. EL CASO DE NAVARRA
Authors: Gurbindo Marin Miguel Ángel
Published: May 2021

La infancia y adolescencia en situacio?n de riesgo/conflicto social configura una realidad que por sus caracteri?sticas da lugar a una de las mu?ltiples caras del espacio social de la exclusio?n. Constituye un colectivo que aunque en te?rminos cuantitativos no sea en la actualidad y en el contexto navarro, muy grande, si que lo es su situacio?n de desproteccio?n, deterioro psicosocial y conflicto social permanente. En nuestro caso hablamos de un colectivo cuyas sen?as de identidad se han ido creando en contextos de desproteccio?n severa y prolongada, sin una cobertura ba?sica de sus necesidades fi?sico-biolo?gicas, emocionales y sociales, asi? como con un insuficiente grado de competencias y habilidades para la interaccio?n socio-familiar. Todo lo cual, hace que este colectivo, este? cada vez ma?s presente en el a?mbito de actuacio?n de la salud mental infanto-juvenil.

Palabras clave: Proteccio?n, Infancia, Riesgo, Adolescencia, Crisis, Exclusio?n social, Salud mental.

Abstract

This paper focuses on the analysis of children and adolescents who live in social conflict. Their identity has been formed in a severe and prolonged context of appalling neglect which does not cover their physical-biological, emotional and social needs. Therefore those human beings do not develop their skills to interact with their relatives and ensure the stability of the family unit. The extent of this phenomenon, as one of the many faces of social exclusion, is not so big in Navarra; however, it must be taken into account that lack of protection, psychosocial impairment, and permanent social conflict increases the risk that pubertal children suffer mental health problems.

Keywords: Protection, Childhood, Risk, Adolescence crisis, Social exclusion, Mental health.

Resumo

A infa?ncia e a adolesce?ncia em situac?a?o de risco / conflito social configura uma realidade que por sua natureza leva a uma das muitas faces de espac?o de exclusa?o social. E? um coletivo que, embora quantitativamente na?o seja grande atualmente no contexto Navarro, a sua falta de protec?a?o sim e? grande, assim como a deteriorac?a?o psicossocial e o conflito social permanente. No nosso caso, falamos de um grupo cuja identidade foi sendo criado no contexto de falta de protec?a?o, sem uma cobertura ba?sica de suas necessidades fi?sicas, biolo?gicas, emocionais e sociais, bem como um grau insuficiente de habilidades de compe- te?ncia para a interac?a?o social e familiar. Tudo isso faz com que este grupo esteja cada vez mais presente no a?mbito da atuac?a?o da sau?de mental infanto-juvenil.

Palavras-chave: Protec?a?o, Infa?ncia, Risco, Crise da adolesce?ncia, Exclusa?o social, Sau?de mental.
EL TRABAJO INFORMAL DE LOS VAGONEROS EN EL METRO DE LA CIUDAD DE ME?XICO
Authors: Ramírez Cárdenas Eloísa , Tunal Santiago Gerardo
Published: May 2021

El objetivo principal de este arti?culo es presentar un estudio exploratorio a partir de un caso que explica de que? forma las condiciones laborales propias del sector informal pudieran determinar la decisio?n de los vendedores ambulantes de permanecer en este en su modalidad de comercio ambulante, especi?ficamente en la venta de arti?culos apo?crifos. La manera en que se operacionalizaron las proposiciones planteadas en la presente investigacio?n fue a trave?s del uso de la observacio?n participante en calidad de compradores y de la aplicacio?n de ocho entrevistas a los vendedores ambulantes mayores de 25 an?os que se dedi- can a la venta de discos compactos (CD’s) piratas dentro de los vagones del Sistema de Transporte Colectivo (STC) Metro de la Li?nea 8 de la Ciudad de Me?xico. Los resultados arrojan que el ingreso, las remuneraciones, la jornada de trabajo y la satisfaccio?n que da el trabajar en el sector informal hace que los sujetos de estudio decidan trabajar en el marco de la informalidad.

Palabras clave: Comercio ambulante, Sector informal, Precariedad laboral, Vagoneros.

Abstract

This paper focuses on the analysis of the decisions made by peddlers to continue working on the streets, specifically selling apocryphal items. Those decisions are based on the working conditions in the informal sector. To collect data, the participant observation was used, as buyers; 8 interviews with vendors, aged over 25, were conducted. These sellers are engaged in the sale of pirated compact discs (CDs) inside the wagons of the Sistema de Transporte Colectivo (STC) Metro Line 8 in Mexico City. The results show that economic income, financial compensation, the working day and the satisfaction of working in the informal sector makes those people keep on working within the framework of informality.

Keywords: Street vendors, Informal sector, Job insecurity, Wagon drivers.

Resumo

O principal objetivo deste artigo e? apresentar um estudo explorato?rio a partir de um caso que explica como as condic?o?es de trabalho no setor informal puderam determinar a decisa?o dos vendedores ambulantes permanecerem em sua modalidade de come?rcio ambulante, especificamente na venda de produtos apo?crifos. As propostas levantadas nesta pesquisa foram realizadas atrave?s do uso da observac?a?o participante com compradores e da aplicac?a?o de 8 entrevistas com os vendedores ambulantes maiores de 25 anos que esta?o envolvidos na venda de discos compactos (CDs) dentro dos vago?es do Sistema de Transporte Pu?blico (STC) Linha de Metro 8 Cidade do Me?xico. Os resultados mostram que a renda, as remunerac?o?es, a jornada de traba- lho e a satisfac?a?o que da? o trabalho no setor informal faz com que os sujeitos deste estudo optem por trabalhar no a?mbito da informalidade.

Palavras-chave: Vendedores ambulantes, Sector informal, Inseguranc?a no emprego.
FEMINICIDIO EN COLOMBIA: RECONOCIMIENTO DE FENO?MENO SOCIAL A DELITO
Authors: Huertas Díaz Omar , Jiménez Rodríguez Nayibe Paola
Published: May 2021

El presente arti?culo tiene como finalidad evidenciar el desarrollo y construccio?n del te?rmino feminicidio en Colombia, a trave?s de la descripcio?n de sus antecedentes, hasta el momento que inicia su consolidacio?n gracias a la motivacio?n de los movimientos feministas, asi? como de mujeres en Latinoame?rica, dando paso al uso del te?rmino en Colombia por parte de la Corte Suprema de Justicia, entidad que lo emplea en una sentencia que dirime un recurso de apelacio?n. Finalmente se realiza la descripcio?n del feminicidio como un delito auto?nomo, pues Colombia para el mes de Julio de 2015 sanciono la norma que lo contempla como tal.

Palabras clave: Feminicidio, Feno?meno social, Delito.

Abstract

This article aims to show the development of the notion of femicide in Colombia. This document outlines its historical background by analyzing how the empowerment feminist movements have made the society aware of this phenomenon. It was the Supreme Court, the highest judicial body that used this notion to give a decision on an appeal. Finally, the description of femicide as a separate offense was enacted as law in July 2015, in Colombia.

Keywords: Femicide, Social phenomenon, Criminal offense.

Resumo

Este artigo tem como objetivo mostrar o desenvolvimento e construc?a?o do feminici?dio na Colo?mbia, atrave?s da descric?a?o de sua histo?ria, iniciando sua consolidac?a?o grac?as a? motivac?a?o do movimento feminista e de mulheres na Ame?rica Latina, dando passo para o uso do termo na Colo?mbia pelo Supremo Tribunal de Justic?a, uma organizac?a?o que utilizou o termo em uma sentenc?a a um recurso de apelac?a?o. Finalmente, se efetua a descric?a?o do feminici?dio como uma infracc?a?o auto?noma para a Colo?mbia no me?s de julho de 2015 que sancionou a norma validando o termo.

Palavras-chave: Femici?dio, Feno?meno social, Crime.
LA E?TICA JUDICIAL EN LA REGULACIO?N DEL MATRIMONIO IGUALITARIO
Authors: Córdoba Baviera Alfonso
Published: May 2021

El presente trabajo tiene una empresa u?ltima concretamente establecida que es la de hacer un barrido expositivo y anali?tico por la apertura del concepto matrimonio a acepciones o realidades hasta principios del siglo XXI jama?s planteadas. Esto es, crear un camino de acceso a la institucio?n matrimonial para las uniones entre personas del mismo sexo. En el caso espan?ol, objeto de este estudio, se ha dado gracias a la aplicacio?n de la e?tica judicial por parte de los Magistrados del Tribunal Constitucional que, con motivo de la mutacio?n constitucional llevada a cabo por el legislador ordinario, se han visto en la obligacio?n de dar un giro jurisprudencial en atencio?n a las demandas de una sociedad cuya realidad es dina?mica y cambiante. Ya el Tribunal Constitucional no ostenta el ti?tulo de legislador negativo sino que, su funcio?n social es mucho ma?s profunda, es el encargado de dar validez y legitimidad a la Constitucio?n.

Palabras clave: Matrimonio entre personas del mismo sexo, E?tica judicial, Tribunal Constitucional.

Abstract

The concrete, ultimate aim of this paper is to make an expository and analytical clear-out to open the concept of marriage to meanings or realities never considered until the early twenty-first century. That is, to create an access road to the institution of marriage to unions between people of the same sex. In the case of Spain, the subject of this study, such road has been created thanks to the application of judicial ethics by judges of the Constitutional Court. On the occasion of the constitutional change carried out by the ordinary legislator, they felt the obligation to provide a jurisprudential turn in response to the demands of a society whose reality is dynamic and changing. The Constitutional Court no longer holds the title of a negative legislator but rather, with a much deeper social function, it is in charge of conferring validity and legitimacy to the Constitution.

Keywords: Same-sex marriage, Judicial ethics, Constitutional Court.

Resumo

Este trabalho tem a finalidade especi?fica de realizar uma varredura expositiva e anali?tica varrido pela abertura do conceito de casamento ate? o ini?cio do se?culo XXI. Ou seja, criar uma estrada de acesso a? instituic?a?o do casamento a unio?es entre pessoas do mesmo sexo. No caso espanhol, objeto deste estudo, se deu grac?as a? implementac?a?o da e?tica judicial por parte dos Jui?zes do Tribunal Constitucional, por ocasia?o da mudanc?a constitucional realizada pelo legislador ordina?rio, eles se viram na obrigac?a?o de efetuar uma mudanc?a jurisprudencial em atenc?a?o a?s exige?ncias de uma sociedade cuja realidade e? dina?mica e muta?vel. E o Tribunal Constitucional na?o dete?m o ti?tulo de legislador negativo, mas a sua func?a?o social e? muito mais profunda, e? o responsa?vel por dar validade e legitimidade a? Constituic?a?o.

Palavras-chave: Casamento do mesmo sexo, A e?tica judicial, Tribunal Constitucional.
Examining the Role of Specialized DNA Polymerases in the Development of Temozolomide Resistance in Glioblastoma Multiforme
Authors:   Department of Chemistry, Cleveland State University, 2121 Euclid Avenue, OH 44115, Cleveland, U.S., Berdis Anthony J.
Published: May 2021

Glioblastoma multiforme (GBM) is an extremely malignant type of primary brain tumor that exhibits a high mortality rate. Current standard therapy involves surgery followed by radiation and treatment with the DNA-alkylating agent, temozolomide (TMZ). While TMZ treatment can extend post-operative survival, most patients develop resistance to TMZ which leads to a significant increase in mortality. At the molecular level, TMZ produces a variety of different DNA lesions including N7-methylguanine, N3-methyladenine, and O6-methylguanine. Although each DNA lesion possesses a unique molecular structure, they all elicit cytostatic and cytotoxic effects against GBM cells. This review article describes the molecular and cellular mechanisms accounting for the anti-cancer activity of TMZ as well as the mechanisms responsible for both inherent and TMZ-induced drug resistance. Special emphasis is placed on understanding the roles that various DNA polymerases play toward the initiation and progression of GBM in addition to mediating resistance to TMZ. This review concludes with discussions on several new approaches that show promise in combating TMZ-resistance, specifically using small molecules to block the replication of DNA lesions catalyzed by various DNA polymerases.
The Reliability and Quality of YouTube Videos as a Source of Public Health Information Regarding COVID-19 Vaccination: Cross-sectional Study
Authors: Chan Calvin , Sounderajah Viknesh , Daniels Elisabeth , Acharya Amish , Clarke Jonathan , Yalamanchili Seema , Normahani Pasha , Markar Sheraz , Ashrafian Hutan , Darzi Ara
Published: May 2021

Background

Recent emergency authorization and rollout of COVID-19 vaccines by regulatory bodies has generated global attention. As the most popular video-sharing platform globally, YouTube is a potent medium for the dissemination of key public health information. Understanding the nature of available content regarding COVID-19 vaccination on this widely used platform is of substantial public health interest.

Objective

This study aimed to evaluate the reliability and quality of information on COVID-19 vaccination in YouTube videos.

Methods

In this cross-sectional study, the phrases “coronavirus vaccine” and “COVID-19 vaccine” were searched on the UK version of YouTube on December 10, 2020. The 200 most viewed videos of each search were extracted and screened for relevance and English language. Video content and characteristics were extracted and independently rated against Health on the Net Foundation Code of Conduct and DISCERN quality criteria for consumer health information by 2 authors.

Results

Forty-eight videos, with a combined total view count of 30,100,561, were included in the analysis. Topics addressed comprised the following: vaccine science (n=18, 58%), vaccine trials (n=28, 58%), side effects (n=23, 48%), efficacy (n=17, 35%), and manufacturing (n=8, 17%). Ten (21%) videos encouraged continued public health measures. Only 2 (4.2%) videos made nonfactual claims. The content of 47 (98%) videos was scored to have low (n=27, 56%) or moderate (n=20, 42%) adherence to Health on the Net Foundation Code of Conduct principles. Median overall DISCERN score per channel type ranged from 40.3 (IQR 34.8-47.0) to 64.3 (IQR 58.5-66.3). Educational channels produced by both medical and nonmedical professionals achieved significantly higher DISCERN scores than those of other categories. The highest median DISCERN scores were achieved by educational videos produced by medical professionals (64.3, IQR 58.5-66.3) and the lowest median scores by independent users (18, IQR 18-20).

Conclusions

The overall quality and reliability of information on COVID-19 vaccines on YouTube remains poor. Videos produced by educational channels, especially by medical professionals, were higher in quality and reliability than those produced by other sources, including health-related organizations. Collaboration between health-related organizations and established medical and educational YouTube content producers provides an opportunity for the dissemination of high-quality information on COVID-19 vaccination. Such collaboration holds potential as a rapidly implementable public health intervention aiming to engage a wide audience and increase public vaccination awareness and knowledge.
Ethical Issues in Patient Data Ownership (Preprint)
Authors: Chiruvella Varsha , Guddati Achuta Kumar
Published: May 2021

UNSTRUCTURED

Patient data have conventionally been thought to be well protected by the privacy laws outlined in the United States. The increasing interest of for-profit companies in acquiring the databases of large health care systems poses new challenges to the protection of patients’ privacy. It also raises ethical concerns of sharing patient data with entities that may exploit it for commercial interests and even target vulnerable populations. Recognizing that every breach in the confidentiality of large databases exposes millions of patients to the potential of being exploited is important in framing new rules for governing the sharing of patient data. Similarly, the ethical aspects of data voluntarily and altruistically provided by patients for research, which may be exploited for commercial interests due to patient data sharing between health care entities and third-party companies, need to be addressed. The rise of technologies such as artificial intelligence and the availability of personal data gleaned by data vendor companies place American patients at risk of being exploited both intentionally and inadvertently because of the sharing of their data by their health care provider institutions and third-party entities.
Distracting Through Procedural Pain and Distress Using Virtual Reality and Guided Imagery in Pediatric, Adolescent, and Young Adult Patients: Randomized Controlled Trial (Preprint)
Authors: Hoag Jennifer A , Karst Jeffrey , Bingen Kristin , Palou-Torres Akasha , Yan Ke
Published: May 2021

BACKGROUND

Children with acute and chronic illness undergo frequent, painful, and distressing procedures.

OBJECTIVE

This randomized controlled trial was used to evaluate the effectiveness of guided imagery (GI) versus virtual reality (VR) on the procedural pain and state anxiety of children and young adults undergoing unsedated procedures. We explored the role of trait anxiety and pain catastrophizing in intervention response.

METHODS

Children and young adults were recruited from the hematology, oncology, and blood and marrow transplant clinics at a children’s hospital. Each study participant completed the GI and VR intervention during separate but consecutive unsedated procedures. Self-report measures of pain and anxiety were completed before and after the procedures.

RESULTS

A total of 50 participants (median age 13 years) completed both interventions. GI and VR performed similarly in the management of procedural pain. Those with high pain catastrophizing reported experiencing less nervousness about pain during procedures that used VR than those using GI. State anxiety declined pre- to postprocedure in both interventions; however, the decrease reached the level of significance during the VR intervention only. Those with high trait anxiety had less pain during GI.

CONCLUSIONS

In our sample, VR worked as well as GI to manage the pain and distress associated with common procedures experienced by children with acute or chronic illnesses. Children who are primed for pain based on beliefs about pain or because of their history of chronic pain had a better response to VR. GI was a better intervention for those with high trait anxiety.

CLINICALTRIAL

ClinicalTrials.gov NCT04892160; https://clinicaltrials.gov/ct2/show/NCT04892160
An Evidence Map on Serious Games in Preventing Sexually Transmitted Infections Among Adolescents: Systematic Review About Outcome Categories Investigated in Primary Studies (Preprint)
Authors: Ilskens Karina , Wrona Kamil J , Dockweiler Christoph , Fischer Florian
Published: May 2021

BACKGROUND

Sexually transmitted infections (STIs) represent a global health risk. Adolescents are at increased risk of infection for several reasons such as lack of knowledge, risky sexual behaviors, and lack of behavioral sills (eg, to negotiate safer sex). Given the fact that adolescents often use digital media and that serious games are considered to have the potential to change knowledge, attitudes and behavior, serious games represent an opportunity for the prevention of STIs.

OBJECTIVE

The aim of this systematic review was to identify and systematically summarize the dimensions that have been investigated in primary studies on serious games targeting STI prevention among adolescents.

METHODS

A systematic review was conducted in PubMed and Web of Science. Studies published from 2009 to 2021 were included that assessed the effectiveness of serious games on adolescent sexual health. A total of 18 studies met the inclusion criteria and were categorized according to dimensions of effectiveness and user experience.

RESULTS

Various dimensions of effectiveness and aspects of user experience were investigated in the primary studies. In total, 9 dimensions of effectiveness were observed: sexual behavior, behavioral intentions, knowledge, attitudes and beliefs, self-efficacy and personal limitations, character traits and future orientation, environmental and individual risk factors, risk perception and risk assessment, as well as normative beliefs and (social) norms. Furthermore, several dimensions related to user experience were investigated in primary studies, that is, motivation, acceptability, trustworthiness, comprehensibility, handling and control, perceived effectiveness, as well as satisfaction.

CONCLUSIONS

This review provides an overview of serious games interventions that are vastly different in approach, content, and even platform. In previous studies, knowledge has already been comprehensively assessed, and a positive influence of serious games on knowledge about sexual topics is evident. The results clearly show that adolescents’ sexual knowledge has been increased by the serious games interventions. However, methodological and content differences in the surveys make it difficult to draw conclusions about the effectiveness related to changes in attitudes and behavior.
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Authors: Trepet H.S. , Trepet L.M. , Havryliuk Ya.A.
Published: May 2021

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Authors: Labunets I.F. , Utko N.A. , Panteleymonova T.N. , Butenko G.M.
Published: May 2021

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Authors: Martsenkovsky I.A. , Martsenkovska I.I. , Makarenko H.V. , Skrypnyk T.O. , Zdoryk I.F.
Published: May 2021

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Authors: Bakhniuk K.D.
Published: May 2021

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Authors: Bilych M.O.
Published: May 2021

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Authors: Zotov Alexey
Published: May 2021

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Construction and Validation of Indian Consumer Ethnocentrism Scale: The Ice-Scale
Authors: Joshi Riddhish N. , Joshi Dr. Yogesh C.
Published: May 2021

Globalization has unlocked and exposed domestic and overseas marketers to superior market opportunities. Additionally, it presents consumers worldwide with a vast number of local and foreign brand choices. Indian consumers, also now, have a broader choice of merchandise at their disposal as economic liberalization and privatization along with globalization have reduced the barriers to trade. In such a setting, the concept of consumer ethnocentrism can deliver deep insights about the preference of consumers toward domestic merchandise. The study aims to develop the Indian Consumer Ethnocentrism Scale (ICE-Scale) and validate the same. Data are collected using a structured questionnaire from urban and rural regions. The study constructed the Indian Consumer Ethnocentrism Scale (ICE-Scale), explored its dimensionality on a sample of 450 respondents, and validated the scale with another sample of 450 using exploratory factor analysis. It was established that the ICE-Scale encompasses two dimensions, namely, protective ethnocentrism and patriotic ethnocentrism. Additionally, the validity testing for the proposed scale and both the constructs were conducted through confirmatory factor analysis. The study advances the existing pool of information in the field of international economics, consumer psychology and global marketing. It also assists domestic producers to get an improved understanding of consumers’ ethnocentric tendencies which in turn would assist them in choosing superior marketing strategies and boosting their sales. The study will not only deliver certain social and policymaking insights to the domestic firms and government but also to the foreign firms functioning or planning to operate in India.
Todos añoran estar cerca de ti
Authors:   Universidad Nacional Autónoma de México (UNAM), Facultad de Medicina, Editora Revista de la Facultad de Medicina, Ciudad de México, México, Fortoul van der Goes Teresa I. ,   Universidad Nacional Autónoma de México (UNAM), Facultad de Medicina, Departamento de Biología Celular y Tisular, Ciudad de México, México
Published: May 2021

One of life's bitterest feelings is loneliness, and when it becomes a constant, it can be debilitating, not only for the body but for the mind.This condition produces great pain and depression that leads to persistent, life-threatening disorders. Karen Carpenter was beautiful and talented, but had developed eating disorders that were denied or minimized by herself and those around her. These destructive habits and widespread abuses, resented her body and turn it into a fragile bundle of bones dissected by lack of nutrients.
Antimicrobial Activity of Andrographis alata (Vahl) Nees
Authors: Yasothkumar N , Sankaralingam S
Published: May 2021

The medicinal properties of plants could be based on their pharmacological effects of the phytochemicals present in them. Hence plant derived antimicrobial properties have received considerable attention in recent years. In the present study, an attempt has been made to screen the antimicrobial potential of Andrographis alata (entire plant), against diseases causing bacterial and fungal pathogens. The results revealed that the methanol extract had an effective antimicrobial activity against all the tested microorganisms and the hexane extract had low antimicrobial activity. Further studies should be carried out to evaluate the other biological active potentials of Andrographis alata.

Keywords: Antimicrobial activity, Andrographis alata, Entire plant extracts.
Formulation Development Studies for Sterile Dosages: A Comprehensive Review
Authors: Raju. N Govind , Ojha Shishir , Roy Sumit Kumar , Kori Amit , Vinukonda Anjaneyulu
Published: May 2021

Sterile generic dosage development requires that specific critical quality attributes be considered and evaluated, regardless of the route of delivery or the type of registration application. The review briefed with an overview of Pharmaceutical Development study requirements. Each of the various stages of studies like Compatibility with the packaging materials, manufacturing vessels, processing aids, MOCs, Filters, Tubing’s and Gaskets also with special studies to be conducted as part of Regulatory Submission, process considerations. Thus, the chapter offers the formulator an overview of the foundational principles associated with formulation development /Pre-formulation studies of sterile products.

Keywords: Pharmaceutical Development, Compatibility, Studies, Hold time.
In Silico Analysis of Laccifer Lacca as a Potential Therapeutic Agent for Cervical, Breast and Lung Cancers
Authors: Kumar Ashish , Kumar Neeraj , Singh Balwan
Published: May 2021

Laccifer lacca has generally been used as pigmenting, coloring agent and dying in chemical industry. Although, it has wide range of industrial applications, but inappropriately, due to lesser availability of data, it has been ignored. Keeping in mind, the wide application of Laccifer lacca, we tried to report the in-silico anti-cancer effects. The experimental techniques used to determine the structure was X-RAY diffraction. The reported resolution of this entry is 2.80 Å. Percentile scores (ranging between 0-100) for global authentication metrics of the record. In silico have a good pool to explore various parameters in molecular docking. We have performed in silico analysis of the active components of Laccifer lacca against the cervical, breast and lung cancer proteins and also found that lac extract enhances the production of anti-inflammatory markers and the increase is significant when compared to the standard vinblastine. It has been demonstrated by Lala and colleagues that a short lived molecule nitric oxide can result in the progression of human tumours. Therefore, the prominent antioxidant activity of phytochemical that can act as inhibitors of nitric oxide production can act as anticancer therapeutics. Both methanolic and aqueous extract shows significant anticancer effect on the hela, MCF-7 & A549 cells suggesting them as potential anticancer therapeutics for future.

Keywords: Laccifer lacca, In-vitro & In-silico analysis, Carcinogenesis, Anti-inflammatory, Molecular Docking.
Regenerative Medicine in Urogynecological Services: Opportunities in Cases of Stress Urinary Incontinence
Authors: Kurniawati Eighty Mardiyan , Rahmawati Nur Anisah
Published: May 2021

Stress urinary incontinence (SUI) is a case that often occurs in women. The handling of this case is not yet fully effective, even though the challenge of health care is to provide quality services and adjust to the needs of the patient. The purpose of this study was to examine the effectiveness of regenerative medicine applied in urogynecology especially in stress urinary incontinence cases as a preliminary study. A selective database search of PubMed, and Google Scholar was conducted to validate the effectiveness of regenerative medicine in urogynecology especially urinary stress incontinence. The search included experimental research, written in English, and has Leak Point Pressure assessment data in the results analysis. Research involves both animals and humans. The search used the following keywords in various combinations: 'stem cell therapy', 'cell-based therapy for SUI', 'regenerative medicine for SUI', and 'tissue engineering'. LPP is an assessor of the success of SUI's services. Most of the studies explored the success and potential of stem cell utilization in cases of stress urinary incontinence even with different types of stem cells. Future studies need to test or experiment the manufacture of stem cell products that can be applied more easily and in the long term.
Keywords: Stress urinary incontinence, stem cell, regenerative medicine
Punica granatum L. (Dadim) Punica granatum L. (Dadim), Therapeutic Importance of World’s Most Ancient Fruit Plant
Authors: Kumari Isha , Kaurav Hemlata , Chaudhary Gitika
Published: May 2021

The custom of using plants for the therapeutic and dietary practices is as old as origin of humanity on the earth. One of the most ancient fruit plant is Punica granatum L., pomegranate belongs to Lythraceae family. The plant has a very rich ethnic history of its utilization around the world. The plant was used to symbolize prosperity, life, happiness, fertility etc. Apart from the ethnic beliefs associated with the plant, it is a well-considered plant based remedy used in treatment of many diseases in traditional system like Ayurveda and folk system of medicine. In Ayurveda it is esteemed as a Rasayana. It is used in many Ayurvedic polyherbal formulations which are used against many diseases. The plant consists of numerous phytochemical constituents in it such as polysaccharides, minerals, polyphenols, tannins, saponins, quinones, alkaloids, glycosides, coumarins, terpenoids, steroids etc. Each of the phytochemical constituent is associated with important therapeutic properties. This supper food is globally known for its high anti-oxidant potential. Other associated properties of this medicinal fruit plant are anti-microbial, hepatoprotective, cardioprotective, anti-diabetic, anti-cancer, immunomodulatory, anti-inflammatory, anti-hypertensive, anti-anemic etc. The aim of present review is to provide information related to phytochemistry, traditional uses in Ayurveda and folk medicinal system and therapeutic properties of Punica granatum L.

Keywords: Dadim, Rasapanchak, Punicalagin, Punicic acid, Anti-oxidant.
HISTORICAL AND THEMATIC EXPOSITION "FORMATION AND DEVELOPMENT OF SCIENTIFIC, TECHNICAL AND PERSONNEL SUPPORT FOR AGRICULTURE MECHANIZATION AND ELECTRIFICATION"
Authors:   Federal Scientifi c Agroengineering Center VIM, Izmailov Andrey , Tsench Yulia
Published: May 2021

The article considered the formation concept of a historical-thematic exposition "Formation and development of scientific, technical and personnel support for the agriculture mechanization and electrification in Russia", covering the historical period from the 18th to the 21st century. The characteristics of the development stages of agriculture mechanization and electrification in Russia in the specified period were given. The creation history of the first agricultural uni-versities which began the systematic training of specialists for agriculture, including for working with agricultural machines and tools was presented. The authors noted the contribution of leading scientists and specialists in the field of agriculture and machines maintenance to the formation of agroengineering science and highly qualified personnel training.
Dependence of Technological Line Automation on the Artificial Intelligence Coefficient of Modular Equipment
Authors:   Federal Scientific Agroengineering Center VIM, Sorokin Konstantin , Sorokin Nikolay , Pestryakov Efim
Published: May 2021

The solution to the automation problems of technological lines depends on the level of artificial intelligence of the equipment that is part of them and the development of digital technologies for managing technological operations. (Research purpose) The research purpose is in studying the theoretical foundations of building human intelligence and its impact on the development of automation of technological lines at the present stage through the formation of artificial intelligence of modular equipment and its adaptation to control systems. The article shows the original part of the methodology for achieving the goal that is based on the development of determining the artificial intelligence coefficient for modular equipment of machine-building enterprises when choosing it for the development of technological lines. (Materials and methods) The article presents the review of research, available scientific materials on the structure of human intelligence, artificial neural networks, the possibility of their use in the development of an electronic computer program, and the intelligence coefficient for the choice of modular equipment in the market of engineering products. Authors studied the theoretical foundations of building human intelligence. The higher the intelligence of a person, the more interested he is in creating equipment and machines based on complex designs and technologies that help him solve the problems of producing that are in demand by society. The effectiveness of this approach is based on the three-dimensional measurement of human intelligence. (Results and discussion) The article presents the interdependence of the automation of the technological line during its development and assembly from the intellectual activity of a person in choosing modular equipment based on its intelligence level coefficient. (Conclusions) The modular equipment used in the assembly of the technological line, if it meets the modern requirements of digitalization, can be combined under the control of artificial intelligence based on artificial neural networks to solve a specific task of automating the technological line.
Efficiency of Anaerobic Processing of Organic Waste in Biofilters Using a Conductive Carrier
Authors:   Federal Scientific Agroengineering Center VIM, Dorokhov Alexey , Kovalev Dmitriy , Fedotov Anatoliy
Published: May 2021

Additional anaerobic treatment of the liquid fraction of the methantenk’s effluent to the content of organic substances that ensure subsequent effective processing under aerobic conditions can be carried out in a biofilter. Processing makes it possible to obtain an additional amount of biogas, reduce the volume of sludge residues. To accelerate the processes of wastewater treatment and optimize the processes of anaerobic processing of wastewater, the use of conductive carriers of inorganic biomass is promising. (Research purpose) The research purpose is in studying the effect of conductive biomass carriers on the efficiency of anaerobic processing of organic waste in biofilters. (Materials and methods) The liquid fraction of the effluent obtained as a result of the gravitational separation of the effluent of the methantenk was used as a substrate for the biofilter. The article describes experimental studies on a test bench that includes two identical bioreactors, in one of which there was placed a biomaterial carrier made of carbon tissue. The article presents a technological scheme and an experimental installation for anaerobic post-treatment of the liquid effluent fraction. (Results and discussion) In the course of experimental studies for 25 days, they showed high stability of the operation of the developed and manufactured experimental installation. In the recycled effluent of a bioreactor with a conductive carrier, the organic substances of the effluent are more fully processed into biogas. The specific (in terms of unit volume of the bioreactor) yields of biogas and methane increased by 14.0 and 22.5 percent; the specific methane yield per gram of raw and decomposed organic matter increased by 22.2 and 7.3 percent. (Conclusions) The use of a biofilter in combination with the immobilization of microorganisms on a conductive carrier allowed to increase the efficiency of fermentation of organic waste by 6 percent, increase the specific yields of biogas and methane, and reduce the volume of sludge residues.
О концепции развития нормативно-технической базы строительных объектов в период их эксплуатации
Authors: Травуш Владимир , Гурьев Владимир , Дмитриев Александр , Дорофеев Владимир , Волков Юрий
Published: May 2021

Рассмотрены проблемы недостаточного развития в России нормативно-технической документации по стадиям жизненного цикла объекта капитального строительства в свете требований Технического регламента о безопасности зданий и сооружений, утверждённого Федеральным законом № 384. Проведён анализ действующих в этой сфере нормативных документов и показан дефицит норм для эксплуатационной стадии, стадии демонтажа и нормативных сроков эксплуатации и их отсутствие для стадии утилизации, оценки состояния, долговечности. Выполнен об­зор и анализ аварий различных видов строительных объектов в России и за рубежом, который подтвердил необходимость совершенствования и развития нормативной базы в области механической безопасности на протяжении жизненного цикла зданий. Приведены сведения по объёму и составу существую­щего жилого фонда России с разбивкой на работоспособное, аварийное и ветхое жилье, видам конструктивных систем, по годам - с 2010-го по 2018-ый год. На основе результатов об­следования массовых серий первого периода индустриального крупнопанельного домостроения в Москве даны рекомендации для принятия решений по их модернизации. Основное внимание уделено требованиям новых базовых сводов правил в области механической безопасности и требованиям экологичности и энергоэффектиности зданий при эксплуатации. Рассмотрен опыт создания зарубежных и отечественных нормативов для цифрового моделирования эксплуатации, включая исполь­зование цифровых моделей объектов. Даны предложения по концепции развития нормативной базы на основе обеспечения комплексной безопасности объектов на протяжении их пол­ного жизненного цикла с выделением первоочередных работ.
Инжиниринговое сопровождение достройки проблемных объектов. Экспертное мнение
Authors: Беляева Елена , Хлебникова Нина , Маргулец Александр , Дари Сергей
Published: May 2021

Рассмотрены масштабы незавершённого строительства многоквартирных жилых домов, возводившихся по дого­ворам долевого участия с привлечением средств граждан, предпосылки формирования проблемных ситуаций, их градостроительные, социальные и технические аспекты. «Долгострои» были и в СССР. В условиях рыночной эконо­мики, вероятность сбоев в финансировании, материально­техническом обеспечении, в оформлении разрешительной и технической документации возросла. Несмотря на дей­ствующую много лет систему государственной регистрации договоров долевого участия и других мер государственного регулирования долевого строительства (214-ФЗ и др.), на практике достаточно часто возникали сложные социаль­но-градостроительные ситуации, затрагивающие интересы большого количества пострадавших граждан, которые вы­нуждены много лет ждать достройки многоквартирного дома или выплаты компенсации.

Показано, что последние изменения в законодательстве предполагают индивидуальные подходы к достройке про­блемных объектов, использующие инжиниринговое сопро­вождения. Считается, что это должно обеспечить снижение административных барьеров, сокращение срока завершения работ, оптимизацию затрат и разрешение сложившихся соци­ально-конфликтных ситуаций. Однако, методика выполнения таких работ отсутствует.

Рассмотрены цели, задачи и требования к методике инжи­нирингового сопровождения достройки проблемного объекта, которая должна стать инструментом обоснования, принятия и реализации решений в рассматриваемой области. Предло­жено создание специализированной нормативно-методиче­ской базы с использованием экспертных методов.

Статья исследует актуальное междисциплинарное на­правление достройки «проблемных объектов» и не относится к конкретной сфере инвестиционно-строительной деятель­ности. Рассмотрены факторы, влияющие на формирование проблемных ситуаций и факторы, условия, необходимые для ее решения.