bluuebunny/crossref_metadata_2025 huggingface dataset:
XV International scientific and practical conference "Legal acts and legal contracts: problems of theory and practice" and the scientific of the "Round Table" "Legal science as a socio-cultural institute: intensification of human, methodological and theoretical potential"
Authors: Krotkova Nataliya V.
Published: October 2021

On April 20 - 22, 2021, the XV International scientific and practical conference "Legal acts and legal contracts: problems of theory and practice" was held at the Russian State University of Justice, and the “Round Table” "Legal science as a socio-cultural institute: intensification of personnel, methodological and theoretical potential" was held within its framework.
Unfortunately, legal contracts and legal acts are very rarely analyzed in the specialized literature. At the conference, some controversial problems of comparative analysis of legal contracts and legal acts were voiced.
The development and formation of legal norms in Russian legislation is closely related to the activities of judicial bodies. The participants of the event touched upon such issues as legal methods for improving the efficiency of judicial activity, etc.
Within the framework of the scientific “Round Table”, it was noted that the problems of the methodology of scientific research in the field of legal sciences are traditionally among the little-studied, but very relevant problems of jurisprudence. In order to determine the main and effective problems of the methodology of legal science, it is advisable to organize a permanent seminar on topical problems of the methodology of legal research with the participation of leading methodologists of legal science on the basis of a leading law university of the country using modern Internet technologies.
The opinion was expressed that an effective means of intensifying legal science can be the rejection from the positivist doctrine of law that prevails in modern educational and scientific legal literature.
Attention is also drawn to the fact that the problem of training scientific and pedagogical personnel is becoming particularly relevant. Only a highly professional, creative team of Russian lawyers is able to eliminate the distortions and imperfections of modern Russian legal science. The “Round Table” also considered the problems of the unity of legal science; the factors that hinder the development of the course "history and methodology of legal science" by undergraduates, and ways to overcome them; the methodology of the study of legal regulation in modern legal science; the use of a sociological approach to law in legal science and other issues.
Wavelet-based multiresolution analysis coupled with deep learning to efficiently monitor cracks in concrete
Authors: Arbaoui Ahcene , Ouahabi Abdeldjalil , Jacques Sebastien , Hamiane Madina
Published: October 2021

This paper proposes an efficient methodology to monitor the formation of cracks in concrete after non-destructive ultrasonic testing of a structure. The objective is to be able to automatically detect the initiation of cracks early enough, i.e. well before they are visible on the concrete surface, in order to implement adequate maintenance actions on civil engineering structures. The key element of this original approach is the wavelet-based multiresolution analysis of the ultrasonic signal received from a sample or a specimen of the studied material subjected to several types of solicitation. This analysis is finally coupled to an automatic identification scheme of the types of cracks based on artificial neural networks (ANNs), and in particular deep learning by convolutional neural networks (CNNs); a technology today at the cutting edge of machine learning, in particular for all applications of pattern recognition. Wavelet-based multiresolution analysis does not add any value in detecting fractures in concrete visible by optical inspection. However, the results of its implementation coupled with different CNN architectures show cracks in concrete can be identified at an early stage with a very high accuracy, i.e. around 99.8%, and a loss function of less than 0.1, regardless of the implemented learning architecture.
Fracture analysis of AA6061-graphite composite for the application of helicopter rotor blade
Authors: Doddamani Saleemsab , Chao Wang Chao Wang , Jinnah M. Sheik Mohamed , Md. Arefin Kowser Md. Arefin Kowser
Published: October 2021

The main objective of the work is to study the fracture behavior of AA6061-graphite material using both experimental technique and finite element simulation by considering helicopter rotor blade as a case study. From the case study, it has been observed that the helicopter rotor blade, made of AA6061, has been failed at the threaded portion of the hole. Experimental fracture toughness is carried out using the compact tension specimens as per ASTM standard testing procedure. Modeling of compact tension specimens and the threaded portion of the bolt hole was utilized to analyze the fracture toughness using a simulation tool. From the results and the comparison, it is recommended to use AA6061-9wt% graphite material as a replacement of AA6061 in the application of main rotor blades of the helicopter.
Supervised Machine Learning Classification Algorithms for Detection of Fracture Location in Dissimilar Friction Stir Welded Joints
Authors: Mishra Akshansh , Vats Apoorv
Published: October 2021

Machine Learning focuses on the study of algorithms that are mathematical or statistical in nature in order to extract the required information pattern from the available data. Supervised Machine Learning algorithms are further sub-divided into two types i.e. regression algorithms and classification algorithms. In the present study, four supervised machine learning-based classification models i.e. Decision Trees algorithm, K- Nearest Neighbors (KNN) algorithm, Support Vector Machines (SVM) algorithm, and Ada Boost algorithm were subjected to the given dataset for the determination of fracture location in dissimilar Friction Stir Welded AA6061-T651 and AA7075-T651 alloy. In the given dataset, rotational speed (RPM), welding speed (mm/min), pin profile, and axial force (kN) were the input parameters while Fracture location is the output parameter. The obtained results showed that the Support Vector Machine (SVM) algorithm classified the fracture location with a good accuracy score of 0.889 in comparison to the other algorithms.
Analysis of static response of RC beams with NSM CFRP/GFRP rods
Authors: Magagnini Erica , Capozucca Roberto , Vecchietti Maria Vittoria
Published: October 2021

In this paper experimental results of investigation on reinforced concrete (RC) beams strengthened with the near surface method (NSM) are analyzed considering the response under bending tests on two beams. One of the RC beams was damaged by bending until the yield of reinforcement and successively strengthened with carbon fiber polymer (CFRP) rod, while the second beam was strengthened with glass-FRP rod. Both the beams have been subjected to bending tests until failure. Experimental diagrams and discussion on static response are presented in the paper. It also places a particular emphasis on the non-linear response of RC sections strengthened with CFRP and GFRP rods under bending moment beyond the first elastic behavior.
Damage identification in steel plate using FRF and inverse analysis
Authors: Khatir Samir , Abdel Wahab Magd , Tiachacht Samir , Le Thanh Cuong , Capozucca Roberto , Magagnini Erica , Benaissa Brahim
Published: October 2021

Metaheuristic algorithms have known vast development in recent years. And their applicability in engineering projects is constantly growing; however, their deferent exploration and exploitation techniques cause the engineering problems to favor some algorithms over others. This paper studies damage identification in steel plates using Frequency Response Function (FRF) damage indicator to detect and localize the healthy and damaged structure. The study is formulated as an inverse analysis, investigating the performance of three new metaheuristic algorithms of Wild Horse Optimizer (WHO), Harris Hawks Optimization (HHO), and Arithmetic Optimization Algorithm (AOA).  The objective function is based on measured and calculated FRF damage indicators. The results showed that the case of four damages with different damage severity levels presented a good challenge where the HWO algorithm was shown to have the best performance.  Both in convergence speed and CPU time.
Minimally invasive versus open transforaminal lumbar interbody fusion for single segmental lumbar disc herniation: A meta-analysis
Authors: Xue Jing , Song Yueming , Liu Hao , Liu Limin , Li Tao , Gong Quan
Published: October 2021

BACKGROUND: Numerous studies on the comparison of minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) and open-transforaminal lumbar interbody fusion (O-TLIF) for the treatment of lumbar disc herniation (LDH) have been published, but there is no clear conclusion. OBJECTIVE: The aim of this study was to evaluate the efficacy of MIS-TLIF compared with O-TLIF in the treatment of LDH in the Chinese population by meta-analysis. METHODS: Studies on the treatment of LDH by MIS-TLIF versus O-TLIF were searched in Pubmed, Web of Science, Medline, Embase, CNKI, VIP and China Wanfang databases from the establishment of the databases to January 2020. The meta-analysis was used to analyze the pooled operation time, intraoperative blood loss, postoperative drainage, postoperative ground movement time, Waist and leg Visual Analogue Scale (VAS) score, Oswestry Disability Index (ODI) score and Japanese orthopaedic association (JOA) score. Mean difference (MD) and standard mean difference (SMD) were used as the effect size. RESULTS: Eleven studies with 1132 patients were included. The results showed that MIS-TLIF compared with O-TLIF, MD =-133.82 (95% CI: -167.10 ∼-100.53, P< 0.05) in intraoperative blood loss, MD =-114.43 (95% CI: -141.12 ∼-87.84, P< 0.05) in postoperative drainage, MD =-3.30 (95% CI: -4.31 ∼-2.28, P< 0.05) in postoperative ground movement time, SMD =-1.44 (95% CI: -2.63 ∼-0.34, P< 0.05) in postoperative low back pain VAS score, SMD = 0.41 (95% CI: 0.15 ∼ 0.66, P< 0.05) in postoperative JOA score, MD = 4.12 (95% CI: -11.64 ∼ 19.87, P> 0.05) in the average operation time, SMD =-0.00 (95% CI: -0.36 ∼ 0.36, P> 0.05) in leg pain VAS score, and SMD =-0.59 (95% CI: -1.22 ∼ 0.03, P> 0.05) in ODI score. CONCLUSION: MIS-TLIF was superior to O-TLIF in the treatment of LDH, especially in the intraoperative blood loss, postoperative drainage, postoperative ground movement time and low back pain in the Chinese population.
A Detailed Study of the Distributed Rough Set Based Locality Sensitive Hashing Feature Selection Technique
Authors: Chelly Dagdia Zaineb , Zarges Christine
Published: October 2021

In the context of big data, granular computing has recently been implemented by some mathematical tools, especially Rough Set Theory (RST). As a key topic of rough set theory, feature selection has been investigated to adapt the related granular concepts of RST to deal with large amounts of data, leading to the development of the distributed RST version. However, despite of its scalability, the distributed RST version faces a key challenge tied to the partitioning of the feature search space in the distributed environment while guaranteeing data dependency. Therefore, in this manuscript, we propose a new distributed RST version based on Locality Sensitive Hashing (LSH), named LSH-dRST, for big data feature selection. LSH-dRST uses LSH to match similar features into the same bucket and maps the generated buckets into partitions to enable the splitting of the universe in a more efficient way. More precisely, in this paper, we perform a detailed analysis of the performance of LSH-dRST by comparing it to the standard distributed RST version, which is based on a random partitioning of the universe. We demonstrate that our LSH-dRST is scalable when dealing with large amounts of data. We also demonstrate that LSH-dRST ensures the partitioning of the high dimensional feature search space in a more reliable way; hence better preserving data dependency in the distributed environment and ensuring a lower computational cost.
EFFECT OF PARENTERAL INFLUENZA VACCINATION ON THE CELL COMPOSITION AND ITS MICROBIOTA OF THE OROPHARYNGEAL SECRETION IN PATIENTS WITH CHRONIC INFLAMMATORY DISEASES OF THE UPPER RESPIRATORY TRACT
Authors: Timchenko M.D. , Timchenko S.V. , Volosevich L.I.
Published: October 2021

Relevance. Until recently, the issues of changes in immunological and microbiological parameters of the oropharynx in vaccinated against viral infections remain insufficiently covered.

Objective: to determine the effect of parenteral influenza vaccination on the cellular and microbial composition of the oropharyngeal secretion in patients with chronic inflammatory diseases of the upper respiratory tract with the presence of anamnestic antibodies to vaccine strains of viruses.

Materials and methods. Oropharyngeal secretion samples of 18 patients with chronic inflammatory diseases of the upper respiratory tract studied before and 3, 12, and 36 weeks after vaccination with inactivated split influenza vaccine. As control 25 donors were used. The cell composition of the sediment was determined. A microbiological study of the oropharyngeal secretion was performed.

Results. At 3 and 12 weeks after vaccination, vaccinated patients significantly changed the relative rates of entry into the oropharyngeal secretion of lymphocytes and the composition of its microbiota while maintaining its total number. After 36 weeks, the cell composition and the representation of pathogenic and opportunistic microflora practically returned to baseline with a significant increase in the total microbiota.

Conclusions. Parenteral administration of inactivated split vaccine to persons with chronic inflammatory diseases of the upper respiratory tract with the presence in the blood of anamnestic antibodies to vaccine strains of viruses is accompanied by a simultaneous temporary increase in lymphocyte representation with a simultaneous decrease in the number of transfusion microflora in the oropharyngeal secretion.
CORRELATION OF GLYCOSYLATED HEMOGLOBIN LEVELS WITH AUDITORY AND VISUAL REACTION TIME IN DIABETICS
Authors: Patil Shweta , Phatale Sangita , Malipatil Basavaraj
Published: October 2021

Relevance. Diabetes mellitus is a group of metabolic disorders wherein hyperglycemia occurs either due to lack of insulin secretion and/or reduced insulin sensitivity of the tissues. One of the commonest complications of diabetes is neuropathy and its severity will depend on how long and how high the hyperglycemia has been prevalent. Chronic hyperglycemia in diabetes affects the peripheral nerves and slows psychomotor responses in persons who do not have proper glycemic control. This decreased psychomotor response because improper glycemic control affects the reaction time in diabetics.

Objective: to assess and compare the auditory and visual reaction time in group-1 and group-2 diabetics and to correlate it with glycosylated hemoglobin (HbA1c) levels in both the groups.

Methods. The study was conducted on 60 subjects aged between 40-50 years after obtaining the permission of the ethical committee of our institution. The group consisted of 60 well-controlled diabetic patients (HbA1c < 7%) with a history of diabetes for 1-10 years attending the medical OPD of Basaveshwar teaching and general hospital, Gulbarga. Diabetics with HbA1c 5-6% were grouped as group-1 and those with HbA1c 6-7% as group 2. The visual reaction time for a green and red light and auditory reaction time for tone and click sound were measured by using reaction time apparatus 2x4, Anand agencies Pune. HbA1c was done by the micro-column method.

Results. The visual and auditory reaction time of diabetics with HbA1c 5-6% was faster as compared to the diabetics with HbA1c 6-7% with P< 0.001 and a statistically significant positive correlation was found between HbA1c levels and the visual and auditory reaction time.

Conclusion. Poor glycemic control slows psychomotor responses and thus affects the visual and auditory reaction time.
Collision breast cancer and chronic lymphocytic leukemia/small lymphocytic lymphoma in a single lymph node (clinical case)
Authors: Zakhartseva L. , Yanovytska M.
Published: October 2021

Summary. Collision synchronous tumors that are found at the same anatomical site are very rare. Their diagnostics, staging and treatment is very complicated. Here we present a clinical case of collision tumor in a single lymph node which consists of breast cancer and chronic lymphocytic leukemia/small lymphocytic lymphoma. The management of such cases is discussed.
Magnetically sensitive nanocomplex enhances antitumor efficacy of dendritic cell-based immunotherapy
Authors: Khranovska N. , Skachkova O. , Gorbach O. , Inomistova M. , Orel V.
Published: October 2021

Summary. Background: One of the major factors restricting in vivo efficacy of dendritic cells (DCs) based immunotherapy is the inefficient migration of these cells to the lymphoid tissue, wherein DCs activate antigen-specific T cells. A fundamentally new approach for the possibility of enhancing the antitumor effects of DC-based immunotherapy may be the use of magnetically sensitive nanocomplexes to increase the target delivery of DCs to the lymph nodes of the recipient. Aim: To study the antitumor and immunomodulatory effects of the DC-nanovaccine with magnetosensitive properties and its influence on the immunosuppressive tumor microenvironment in mice with sarcoma 37. Materials and Methods: The antitumor, antimetastatic and immunomodulatory effects of DCs loaded with magnetic nanocomplex under magnetic field (MF) control in mice with sarcoma 37 have been investigated. Results: Combined therapy contributed to a significant reduction in tumor volume and weight compared to the control group of mice and mice that received the DC vaccine without MF. Therapy with magnetically sensitive DC nanovaccine with and without the addition of the MF was accompanied by a significant down-regulation of the level of FoxP3, transforming growth factor β, interleukin (IL)-10 and vascular endothelial growth factors, mRNA expression in tumor tissues. A significant increase in interferon-γ and IL-4 mRNA expression was found in mice treated with the magnetically sensitive DC nanovaccine under MF control. Conclusion: A significant increase in the antitumor efficacy of the DC vaccine can be achieved using magnetosensitive nanocarriers of tumor antigens under MF control.
Neutrophil to lymphocyte ratio as a prognostic marker for non-metastatic renal cell carcinoma — does it add to what we already know?
Authors: Rawoot S. , Punatar C. , Singh V. , Anand A. , Shah B. , Nagaonkar S. , Joshi V.
Published: October 2021

Summary. Aim: To study the correlation of pre-operative neutrophil to lymphocyte ratio (NLR) with pathological stage, Fuhrman grade, sarcomatoid differentiation, tumor necrosis and lymph node positivity and its prognostic role in non-metastatic renal cell carcinoma (non-mRCC). Materials and Methods: This retro-prospective, observational study was done at a tertiary care center in Mumbai, India. All patients with non-mRCC from July 2015 to April 2018 were included. Patients with co-existing systemic infection, prior immunotherapy, and long-term steroids were excluded. NLR closest to surgery, but within one month prior to surgery was used. Patients were stratified as NLR ≥ 3.0 or < 3. NLR was correlated with known prognostic factors by Pearson’s correlation. Results: 113 patients, aged 18–81 years (83 males and 30 females) were included. 75% had clear cell RCC. 62% had stage 1 disease. 58% patients had Fuhrman Grade 2. 10 patients had lymph node metastasis, 6 had sarcomatoid differentiation, 40 had tumor necrosis. The NLR was < 3 in 72 patients. Statistically significant correlation between NLR and tumor stage (p = 0.0054) as well as NLR and tumor necrosis (p = 0.0128) was shown. Conclusions: NLR correlates significantly with higher T stage and tumor necrosis. NLR may be integrated with well-established prognostic markers to improve the accuracy of prognostic scores.
Can SARS-CoV-2 change individual radiation sensitivity of the patients recovered from COVID-19? (experimental and theoretical background)
Authors: Chekhun V.F. , Domina E.A.
Published: October 2021

Summary. R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Science of Ukraine has been studying the mechanisms and specificities of individual radiation sensitivity (IRS) formation in professionals who work in the field of ionizing radiation, cancer patients and representatives of other population groups. Our data based on the use of G2-test in in vitro irradiated blood lymphocytes in late G2-period of cell cycle indicated an increased carcinogenic risk in professionals with high IRS. We suggest that the COVID-19 pandemic could make significant adjustments in the formation of IRS in professionals who have survived the disease and continue to work with ionizing radiation (IR). Increased systemic inflammatory activity, which persists for a long time in COVID-19 patients, in combination with low-dose range irradiation (professionals who continue to work with IR) and with local irradiation in the high-dose range (radiation therapy for cancer patients) may affect IRS. Repeated determination of IRS in professionals who have had COVID-19 infection, using chromosomal G2-radiation sensitivity assay will answer the question: can SARS-CoV-2 coronavirus affect the IRS? The proposed hypothesis of the radiosensitivity evolution needs further experimental validation using a set of radiobiological indices to clarify the mechanism of IRS formation following COVID-19 infection. The detected changes (increase) of human IRS after COVID-19 must be taken into account for personalized planning of radiotherapy of COVID-19 cancer patients.
Permasalahan kepemimpinan dan pengembangan karir dan pengaruhnya terhadap produktivitas kerja guru
Authors: Wahyudi Imam
Published: October 2021

The purpose of this study is to analyze the simultaneous, partial and dominant influence of the variable Leadership and Career Development on teacher work productivity. This type of research is explanatory research, namely research that aims to determine the relationship between the two variables of leadership and career development on teacher work productivity. The research population was the Riyadlul Jannah Pacet Junior High School teacher, Mojokerto. Data analysis used multiple linear regression. The results of the study show that: 1) leadership and career development have a simultaneous effect on teacher work productivity. 2) leadership and career development have a partial effect on teacher work productivity. 3) career development has a dominant effect on teacher work productivity.
Analisis Harga dan Kualitas Produk serta Pengaruhnya terhadap Loyalitas Konsumen pada Rijan Mart I Prambon Sidoarjo
Authors: Wahyudi Slamet
Published: October 2021

The purpose of this study was to analyze the simultaneous, partial and dominant effect of the variable price and product quality on consumer loyalty. The research method explains that the location as a business institution, the type of research is explanatory research, namely research that aims to determine the relationship between the two variables price and product quality on consumer loyalty. The research population is consumers who are taken incidentally. Data analysis used multiple linear regression. The results showed that: 1) price and product quality had a simultaneous effect on consumer loyalty. 2) price and product quality have a partial effect on consumer loyalty. 3) product quality has a dominant effect on consumer loyalty.
O Desafio de se Implantar a Assistência Oncológica no SUS
Authors: Kligerman Jacob
Published: October 2021

O editorial faz um panorama dos desafios de expansão da assistência oncológica no SUS.
Controle de sintomas do câncer avançado em adultos: normas e recomendações do INCA
Authors: Instituto Nacional de Câncer
Published: October 2021

Normas e recomendações do INCA no controle de sintomas do câncer avançado em adultos.
A História da Radioterapia no INCA
Authors: Guizzardi Miguel Fernando , Guimarães Darcy da Silva
Published: October 2021

De forma cronológica, o artigo retrata a História da Radioterapia no INCA.

.
Aspectos Fúngicos do Câncer Bucal
Authors: Kignel Sérgio , Birman Esther Goldenberg
Published: October 2021

Tendo em mente os aspectos relacionados à presença de fungos e seu discutível papel em relação ao câncer bucal, avaliou-se 33 pacientes fumantes e etilistas crônicos, livres de qualquer tratamento antineoplásico ou antifúngico, com carcinoma epidermóide da mucosa bucal em estádio T1N0M0 ou T2N0M0. Após exame clínico local, foram realizadas coleta, cultura e identificação de fungos, observando-se, no grupo em estudo, predominância do sexo masculino e presença de lesões do tipo ulcerativo, localizadas, principalmente, no assoalho bucal e, em menor número, em outras áreas. Dos 42 pacientes, 4% eram portadores de fungos, destacando-se a presença de Candida albicans, além de outras seis espécies, ora associadas ora isoladas. Lesões clínicas sugestivas de candidíase pseudo-membranosa ou eritematosa não foram detectadas. Mesmo frente à ausência de manifestações clínicas de candidíase, é necessário lembrar que mudanças podem ocorrer em face do desenvolvimento de neoplasia, tratamento instituído ou mesmo condições imunológicas, facilitando a seletividade, colonização e desenvolvimento patogênico dos fungos, merecendo estes pacientes atenção e cuidados frente aos aspectos micológicos envolvidos.
Considerações Sobre a Terapia de Captura de Nêutrons pelo Boro
Authors: Campos Tarcisio Passos Ribeiro de
Published: October 2021

Este artigo descreve a técnica de radioterapia chamada “Boron Neutron Capture Therapy” (BNCT), isto é, Terapia de Captura de Nêutrons por Boro. Serão abordados conceitos básicos em BNCT, em particular como esta técnica tem sido usada na tentativa de combater glioblastoma multiforme. Uma breve revisão histórica dos estudos clínicos feitos nas décadas de 50 e 60 será apresentada, incluindo resultados recentes do Laboratório Nacional de Brookhaven - BNL e do Instituto Tecnológico de Massachusetts - MIT. A experiência japonesa na área será comentada. Atualmente, novas ensaios clínicos no MIT e BNL foram iniciados, tentando obter a cura para o glioblastoma multiforme e melanoma intracranial periférico. Dados radiobiológicos e protocolos clínicos usados na Fase I do MIT serão apresentados. Considerações de como BNCT poderá ser aplicado no Brasil serão traçadas. O artigo aponta para a possibilidade de utilização da braquiterapia via Cf-252 acoplada à técnica de terapia de captura de nêutrons – NCT como uma alternativa simples e barata de implementação de BNCT no país.
Serum Albumin is Independent Predictor of Hospital Mortality in Patients with Cancer
Authors: Lima Emanuelle do Nascimento Santos , Ferreira Isabela Borges , Silva Nayara Cristina da , Prestes Isaías Valente , Pena Geórgia das Graças
Published: October 2021

Introduction: Cancer is one of the leading causes of morbidity and mortality worldwide. There are few studies showing adjusted models with other predictors of mortality by a conceptual model perspective. Objective: The objective of this study was to verify the prediction of albumin and Prognostic Nutritional Index (PNI) with in-hospital mortality in cancer patients. Method: Retrospective study was performed from 2014 to 2016 with 262 cancer patients (gastrointestinal tract, male genital organs, breast, metastasis, urinary tract, head and neck and others). Demographic data, blood counts, C-reactive protein, albumin, and haematological indexes (Prognosis nutritional index - PNI, Neutrophils to lymphocytes ratio - NLR, Monocytes lymphocytes ratio - MLR, Platelets to lymphocytes ratio - PLR and Platelets to albumin ratio - PAR), nutritional diagnoses and hospital outcomes (discharge or death) were collected. The cumulative probability of death was calculated by Kaplan-Meier curves, and survival analyses were performed using the Cox proportional hazards model. Results: The frequency of death among the study patients was 10.7% (28). Among the patients who died, 99.2% (26) presented some degree of malnutrition (p=0.004). In the multivariate analysis, serum albumin (<3 g/dL) was independently associated with in-hospital mortality (HR=3.43, 95% CI 1.11-10.63). On the other hand, the PNI was not associated with in-hospital mortality. Conclusion: Serum albumin levels during hospitalization were predictors of in-hospital mortality in the population evaluated. These results suggest that the serum levels of this protein can be used in clinical practice, adding prognostic information in patients with cancer.
DETERMINANTS OF PRICE DISCRIMINATION INFLUENCE VECTOR ON PUBLIC WELFARE
Authors: Harchuk Vladyslava , Gerasymenko Anzhelika
Published: October 2021

The article considers the nature of price discrimination, defined by different researchers. It mainly relates to strategic behaviour of firms that sell the same product to different consumers at different prices. On the one hand, it leads to redistribution of consumer surplus to producer that reduces a public welfare, being a negative consequence of price discrimination. On another hand, the price discrimination provides access of low-income people to a product. It is the way for them to buy it at a reduced price, and this is a positive consequence of price discrimination on public welfare.
The article depicts positive effects of price discrimination with examples of banking (deposit rates), cosmetics (season tickets) and education markets (tuition fee). These markets are distinguish by dispersed structure that is favoured for competition. Negative effects in the article are depicted with example of glucose syrup market, marked with a dominance. These examples, as well as the results of theoretical research, witness that a market structure is one of the determinants of a vector of price discrimination influence on public welfare. Another determinant (behavioural) is defined by Pike – Shastitko criteria, among which are: exploitation of a dominance, distorting of competition on the downstream markets (leverage of dominance), and reducing of the potential competition.
Considering of the above-mentioned structural and behavioural determinants of the vector of price discrimination influence on public welfare asks for relevant legal reflection within the system of state regulation of price discrimination. The authors analyse the current Ukrainian legal framework of price discrimination regulation, highlighting the gaps which are still exist, determining mostly negative effects of price discrimination influence on the public welfare of Ukrainians. They develop the recommendation of how to do balance its negative and positive effects through change of legislation, in particular, the introduction of certain requirements for exemption from competition law, starting from the foreign, mainly American, experience.
ESTIMATION OF BALANCE OF PAYMENTS OF UKRAINE
Authors: Tyshchenko Volodymyr , Tyshchenko Olena
Published: October 2021

The article highlights the features of the formation and assessment of the balance of payments in Ukraine. The balance of payments of Ukraine is a functional macroeconomic model that reflects all transactions that are carried out between the subjects of the national economy and the subjects of the economies of other countries of the world. This model allows you to develop and implement a sound foreign economic policy of Ukraine, analyze the state of commodity and financial markets, conduct scientific research of economic processes in the state, etc. Ukraine is actively implementing the methodology of balance of payments formation according to the recommendations of the International Monetary Fund. Ukraine's balance of payments by main components is grouped into two accounts: "capital and financial transactions" and "current transactions": capital transactions cover all transactions related to the receipt or payment of capital transfers and the acquisition or sale of property rights and non-financial assets; current transactions include all transactions between residents and non-residents on real values, as well as transactions on the free provision or receipt of valuables for current use. Like any other "balance of payments" consists of receipts and payments. It is active (surplus) when revenues are greater than payments and passive (deficit) when payments are greater than revenues. Based on the assessment of the balance of payments of Ukraine for 2020, certain conclusions can be drawn: stable external demand for food softened the drop in exports of goods from Ukraine during the COVID-19 pandemic, and the increase in prices contributed to its growth at the end of 2020; despite a slight recovery in domestic demand in the IV quarters of 2020, imports of goods to Ukraine by the results of 2020 decreased significantly; the current account surplus in Ukraine in 2020 was provided by a significant positive balance of trade in services and a record surplus of the primary income account; capital outflow from Ukraine on the financial account stopped at the end of 2020 due to the optimism of investors; despite the crisis and significant payments on external debt, Ukraine's gross reserves increased in 2020, and the financial crisis once again confirmed the importance of both international support and a balanced macroeconomic policy. The current account surplus in Ukraine in 2020 reached one of the largest levels in the history of Ukraine, it was formed due to a significant decrease in imports of goods and services, a reduction in payments on primary income and the relative stability of exports of goods and remittances. The article proposes recommendations for improving approaches to the formation of the balance of payments in Ukraine using certain methods when regulating the balance of payments of the state.
STRATEGIC ASPECTS OF RECONSTRUCTION OF ECONOMIC RESILIENCE OF UKRAINIAN ENTERPRISES IN CONDITIONS OF CORONAVIRUS CRISIS
Authors: Birbirenko Svitlana , Banket Natalia
Published: October 2021

The pandemic of coronavirus infection COVID-19 has radically changed the course of world economic processes, and Ukrainian in particular. The consequences of the pandemic have significantly affected the economic stability of Ukrainian enterprises, demonstrating to them the urgent need to restore their economic stability.
Despite the fact that a large number of leading Ukrainian and foreign scientists study the formation and maintenance of economic stability of the enterprise, some issues remain insufficiently covered, namely, they do not contain enough proposals to restore economic stability of enterprises operating in the coronavirus crisis.
Purpose of the article is to study the impact of the coronavirus infection pandemic COVID-19 on the economic sustainability of world economies, as well as Ukrainian enterprises with further development of practical recommendations for the implementation of strategic aspects of its recovery.
Methods of observation, comparison, analysis, analytical method and method of statistical analysis had used.
It has established that the main factor of destabilizing influence on modern world economic processes is the pandemic of coronavirus infection COVID-19. The world’s largest economies in the second quarter of 2020 due to the crisis caused by COVID-19 suffered the highest, even record rates of GDP reduction. The decline in Ukraine’s GDP in this period was 11.4%. However, a decrease in the depth of decline of most types of Ukrainian economic activity has recorded. The above necessitated the development of strategic aspects of restoring the economic stability of Ukrainian enterprises, which have proposed in their practical activities in order to avoid the negative consequences of the coronavirus crisis.
Given the effects of the coronavirus crisis, the development and recommendation for the practical application of strategic aspects of restoring the economic stability of Ukrainian enterprises has become an urgent need. We believe that the implementation of the proposed strategic recommendations will allow Ukrainian businesses to avoid a deep economic crisis and bankruptcy.
MINING AND METALLURGICAL COMPLEX OF UKRAINE: CURRENT TRENDS AND RESULTS
Authors: Honcharuk Olha , Riabko Olexandr , Overkovskyi Bohdan
Published: October 2021

The article analyzes the production and sales results of the enterprises of the mining and metallurgical complex of Ukraine (hereinafter MMC) in 2020, in the first quarter and for four months of 2021, as well as the preconditions that developed in 2019.
It was determined that the results of production of MMC of Ukraine in 2019 were the worst for the entire period of the existence of independent Ukraine. The article analyzes the factors of ineffective work of metallurgical and mining enterprises in this period.
In 2020, the situation was aggravated by the COVID-19 pandemic. Steel production declined, while pig iron and rolled products increased marginally compared to 2019. Exports of iron ore increased by almost a quarter, which means that the success of the ore segment partially offset the difficulties in the metallurgical sector. Success factors for the ore segment of the mining and metallurgical complex of Ukraine in 2020 were: rapid recovery of China after quarantine, effective measures to support the economy by China and European countries, high demand and prices for ore, rapid recovery of business activity and low level of stocks, which led to an increase in prices for metal products.
It was determined that in the first quarter of 2021 the production of pig iron, rolled products, sinter increased compared to the same indicator in 2020, but the production of coke, steel and pipes decreased. The export of the main products of the mining and metallurgical complex has grown significantly.
In April 2021, there was a drop in exports of iron ore and ferrous metals compared to March, but in general, for four months of 2021, the dynamics of exports is positive.
The article examines positive trends (growth in prices for iron ore raw materials, demand and prices for steel and rolled products), as well as risks and threats that have arisen in the market and which will affect the efficiency of mining and metallurgical enterprises in 2021 and in the long term (a slowdown in the growth of the Ukrainian economy and countries-consumers of mining and metallurgical products, a high level of protectionism, insufficient protection of the domestic market from imports of metal products, the need for significant investments in improving the environmental friendliness of metallurgical production and increasing environmental costs.
PECULIARITIES OF USING BUSINESS ANALYSIS TECHNIQUES IN ADMINISTRATIVE MANAGEMENT DURING THE COVID PANDEMIC-19
Authors: Kompanets Kateryna , Lytvyshko Liliia , Horodetskyy Mykola
Published: October 2021

The current state of motor transport enterprises, which is characterized by negative dynamics of development in all sectors of the transport sector, is studied. The research of scientific works determined the direction of the article and the object of research was business processes in administrative management. That is, it is impossible not to agree with the authors to solve the crisis of modern enterprises. It should be noted that all of them are solved through the mechanisms of the administrative management system. Therefore, it became necessary to form conceptual features of the use of business analyst in administrative management during the Covid pandemic 19. Modern approaches to administrative management are considered, providing reliable administrative management of the motor transport enterprise. Management of business processes in motor transport enterprises of business provides their constant improvement and optimization therefore the most important tools of process management are approaches and methods of improvement of business processes managed by administrative management systems. The researched approaches are aimed at identifying duplication of functions, bottlenecks, cost centers, quality of individual operations, missing information, the possibility of automation and quality management.
The main directions and software products for automation of business processes in the system of administrative management are established. It is proved that the holistic application of approaches and elements of business analyst in the administrative management of the enterprise will lead to great chances of maintaining the competitiveness of motor transport enterprises and ways out of the post-crisis crisis. The measures of administrative management concerning improvement of activity of the motor transport enterprises are offered. Therefore, in order for trucking companies to develop and differ from their competitors in the level of services provided and the level of comfort, in the critical conditions of the COVID-19 pandemic it is necessary to radically change the methods of administrative management, ie reengineer business processes.
METHODOLOGY FOR FORMING AND IMPLEMENTING A TOUR AND DETERMINING ITS ECONOMIC EFFICIENCY
Authors: Krasnoded Tetiana , Bakina Tetiana , Zakharchenko Olena
Published: October 2021

The relevance of the study of issues in the context of tour operator activity is determined. Important issues of formation and promotion of the tour as the main component of tourist products are considered. A tour project is presented and an algorithm for creating a tourist product for several days for a specific tourist destination is demonstrated. The mechanism for determining the cost of a tour is revealed, which includes the cost of accommodation, meals, travel, excursion services and entertainment, support, insurance and other additional services provided to consumer tourists within the framework of a tourist project. At the same time, a mechanism for calculating individual elements of the tour price is presented. The method of calculating the company's profit and economic efficiency from the sale of the tour is revealed. General marketing directions in tourism are also proposed, which can be used to determine the preferences of tourists, present and promote almost all tourist products.
STRUCTURE AND EFFICIENCY OF INVESTMENTS IN THE SPORTS INDUSTRY OF THE COUNTRIES (EXAMPLE OF THE GERMAN ECONOMY)
Authors: Kafurina Anastasiia , Rodionova Tetiana
Published: October 2021

In the last thirty years sport is turning into business and football clubs are developing into large corporations. Sports industry has been becoming not just more exciting but also highly lucrative. The value of professional football sector is estimated to be about 8 billion euros. Even more investors see sports leagues or football clubs as profitable investments. For instance, European Super League can be taken, which could have been more profitable for investors than other competitions and attracted such sponsor as JPMorgan Chase. However, in the near future such project has no support from governments and other clubs and therefore has no future yet. One type of investment in the sports industry is the purchase of shares in sports clubs. Borussia Dortmund is a German football club, one of the most successful clubs in the world, which plays in the Bundesliga, the top tier of the German league system. Dortmund’s shares are listed on the Frankfurt Stock Exchange. Borussia is the only club in Germany and among approximately 25 clubs in the world, including few British and Italian clubs, whose shares are publicly traded. Even more clubs are considering going public to increase its capital. One of the biggest clubs in Belgium, Brugge examined such opportunity, though the club postponed their initial public offering because of the low demand. On the contrary, Ukrainian football club Veres started selling its shares in April 2021 and during the first day have received bids for the purchase of stocks for the amount of over 36 million hryvnas. However, the benefit for the investor might be only the increase of a share price as the club does not intend to pay out dividends. The article analyses the price of a club share for more than 20 years and historical dividends. Borussia’s stock is analysed using futures contracts. It also examines such indicators as return on invested capital (ROIC), weighted average cost of capital (WACC), return on assets (ROA), which are compared with those of Manchester United, Juventus, Lazio and Ajax. A model is being built to predict the stock price during COVID-19 and before the start of the pandemic to compare price fluctuations and model errors.
IMPLEMENTATION OF INNOVATIVE TECHNOLOGIES TO INCREASE COMPETITIVENESS OF THE ENTERPRISE HOTEL AND RESTAURANT INDUSTRY
Authors: Shelemetieva Tetiana , Hres-Yevreinova Svitlana
Published: October 2021

The article is investigated the theoretical aspects of innovation in the hotel and restaurant industry. The scientific analysis of concepts and categories «innovation», «novation» is carried out. It is proved that the introduction of innovative technologies is an essential condition for increasing the competitiveness of the hotel and restaurant business.
The experience of innovative activity of the hotel and restaurant enterprise on the example of the Turkish hotel “Pacco Boutique Hotel” is considered. It was found that the hotel management pays the most attention to product and process innovations.
With the help of SWOT-analysis identified strengths and weaknesses, possible ways to increase the competitiveness of the enterprise. The main weaknesses of the company are - insufficiently qualified staff, low percentage of external financing and insufficient marketing campaign.
The influence of external factors, especially technological, on the formation of enterprise competitiveness by means of PEST-analysis is investigated. It clearly shows that the company follows modern trends as far as its financial capabilities. As the hotel uses a protective innovation strategy, first the experience of the leaders of the hospitality industry market is analyzed, and only then the innovations that have already successfully proven themselves are implemented.
The main shortcomings in the innovative activity of the hotel and restaurant enterprise “Pacco Boutique Hotel” have been revealed. The management mainly focuses on the development of technological innovations – product and process, but does not pay due attention to organizational and managerial. Insufficiently qualified service personnel, lack of proper control over the quality of service provision, lack of trainings and training systems, advanced training. Such significant shortcomings of the enterprise can lead to loss of competitive positions, trust of visitors.
Practical recommendations for improving and implementing innovative technologies in the enterprise to increase competitiveness are offered. The main proposals are the introduction of the latest methods of training and retraining of staff, an innovative method of quality management and competitiveness – benchmarking, as well as an enhanced marketing strategy on social networks on platforms such as Instagram and Facebook.