bluuebunny/crossref_metadata_2025 huggingface dataset:
Normative Values and Psychometric Properties of EQ-5D-Y-3L in Chilean Youth Population among Different Weight Statuses
Authors: Perez-Sousa Miguel Angel , Olivares Pedro R. , Carrasco-Zahinos Rocio , Garcia-Hermoso Antonio
Published: February 2023

Background: This study aimed to provide population norms among children and adolescents in Chile using the EQ-5D-Y-3L questionnaire and to examine its feasibility and validity among body weight statuses. Methods: This was a cross-sectional study in which 2204 children and adolescents (aged 8–18 years) from Chile completed a set of questionnaires providing sociodemographic, anthropometric and health-related quality of life (HRQoL) data using the five EQ-5D-Y-3L dimensions and its visual analogue scale (EQ-VAS). Descriptive statistics of the five dimensions and the EQ-VAS were categorized into body weight status groups for the EQ-5D-Y-3L population norms. The ceiling effect, feasibility and discriminant/convergent validity of the EQ-5D-Y-3L were tested. Results: The dimensions of the EQ-5D-Y-3L questionnaire presented more ceiling effects than the EQ-VAS. The validity showed that the EQ-VAS could discriminate among body weight statuses. However, the EQ-5D-Y-3L index (EQ-Index) demonstrated a non-acceptable discriminant validity. Furthermore, both the EQ-Index and the EQ-VAS presented an acceptable concurrent validity among weight statuses. Conclusions: The normative values of the EQ-5D-Y-3L indicated its potential use as a reference for future studies. However, the validity of the EQ-5D-Y-3L for comparing the HRQoL among weight statuses could be insufficient.
Acetylsalicylic Acid Effect in Colorectal Cancer Taking into Account the Role of Tobacco, Alcohol and Excess Weight
Authors: Florensa Didac , Mateo Jordi , Solsona Francesc , Galván Leonardo , Mesas Miquel , Piñol Ramon , Espinosa-Leal Leonardo , Godoy Pere
Published: February 2023

Excess weight, smoking and risky drinking are preventable risk factors for colorectal cancer (CRC). However, several studies have reported a protective association between aspirin and the risk of CRC. This article looks deeper into the relationships between risk factors and aspirin use with the risk of developing CRC. We performed a retrospective cohort study of CRC risk factors and aspirin use in persons aged >50 years in Lleida province. The participants were inhabitants with some medication prescribed between 2007 and 2016 that were linked to the Population-Based Cancer Registry to detect CRC diagnosed between 2012 and 2016. Risk factors and aspirin use were studied using the adjusted HR (aHR) with 95% confidence intervals (CI) using a Cox proportional hazard model. We included 154,715 inhabitants of Lleida (Spain) aged >50 years. Of patients with CRC, 62% were male (HR = 1.8; 95% CI: 1.6–2.2), 39.5% were overweight (HR = 2.8; 95% CI: 2.3–3.4) and 47.3% were obese (HR = 3.0; 95% CI: 2.6–3.6). Cox regression showed an association between aspirin and CRC (aHR = 0.7; 95% CI: 0.6–0.8), confirming a protective effect against CRC and an association between the risk of CRC and excess weight (aHR = 1.4; 95% CI: 1.2–1.7), smoking (aHR = 1.4; 95% CI: 1.3–1.7) and risky drinking (aHR = 1.6; 95% CI: 1.2–2.0). Our results show that aspirin use decreased the risk of CRC and corroborate the relationship between overweight, smoking and risky drinking and the risk of CRC.
Changes in the Histological Structure of Adrenal Glands and Corticosterone Level after Whey Protein or Bee Pollen Supplementation in Running and Non-Running Rats
Authors: Frankowska Karolina , Zarobkiewicz Michał , Sławiński Mirosław A. , Wawryk-Gawda Ewelina , Abramiuk Monika , Jodłowska-Jędrych Barbara
Published: February 2023

Due to the many health-promoting properties of bee pollen and whey protein, both products are widely used as dietary supplements. According to these reports on their health-promoting properties, the aim of our study is to assess whether these products can influence the structure and function of the adrenal glands in rats. Thirty male Wistar rats were divided into six equal groups. Among them, there were three groups which included non-running rats and three groups which included running rats. Both of these running (n = 3) and non-running (n = 3) groups included non-supplemented (control groups), bee-pollen-supplemented groups, and whey-protein-supplemented groups. After 8 weeks, the rats were decapitated, their adrenal glands were collected, and paraffin slides were prepared. Then, staining according to the standard H&E and Masson’s trichrome protocols was performed. Fecal and urine samples were collected prior to the end of the study to measure corticosterone levels. In the group of non-running rats, the consumption of bee pollen was noted to be significantly higher when compared to the group of running rats (p < 0.05). The thickness of the particular adrenal cortex layers was similar among all of the groups (p > 0.05). The statistically significant changes in the microscopic structure of the adrenal glands, especially regarding cell nuclei diameter and structure, as well as the architecture of sinusoids, were observed between the groups. Moreover, urine corticosterone concentrations were found to vary between all of the analyzed groups (p < 0.05). These results indicate that both bee pollen and whey protein have limited stress-reducing potential.
Psychological Well-Being of Cancer Patients before and during the Pandemic: The Impact of COVID-19 Peritraumatic Distress
Authors: Bochicchio Ilaria , La Rosa Valentina , Marino Graziella , Craparo Giuseppe , Commodari Elena , Deiana Giovanni , Sanseverino Francesca , Tartarone Alfredo , Conca Raffaele , Lettini Alessandro
Published: February 2023

Background: This study aimed to evaluate the psychological impact of the COVID-19 pandemic on cancer patients. Methods: Ninety cancer patients undergoing chemotherapy with antiblastics were recruited from a tertiary medical center and completed a battery of standardized questionnaires to assess anxiety, depression, peritraumatic stress, and quality of life before and during the pandemic. Results: Quality of life worsened significantly during the pandemic compared with the pre-pandemic period. Anxiety and depression levels also increased significantly during the pandemic. COVID-19 peritraumatic distress significantly predicted lower quality-of-life scores during the pandemic. Conclusions: COVID-19 distress affected the overall quality of life of patients who already had lower levels of quality of life before the pandemic and who had advanced cancers. Cancer patients must receive adequate support from psychiatrists and psychologists to mitigate the psychological distress related to the pandemic.
The Other Side of the ACEs Pyramid: A Healing Framework for Indigenous Communities
Authors: Rides At The Door Maegan , Shaw Sidney
Published: February 2023

For over two decades, extensive research has demonstrated significant associations between adverse childhood events (ACEs) and a wide range of negative health, mental health, and social outcomes. For Indigenous communities globally, colonization and historical trauma are commonly associated with ACEs, and these effects reverberate through generations. While the ACEs conceptual framework expanded pyramid is a useful model and a visual aid for understanding the historical and present-day dimensions of ACEs in Indigenous communities, a healing conceptual framework is needed to outline a path toward increased community well-being. In this article, we provide a holistic Indigenous Wellness Pyramid that represents the other side of the ACEs pyramid to guide pathways toward healing in Indigenous communities. In this article, the authors describe the Indigenous Wellness Pyramid according to each of the following contrasts with the ACEs pyramid: Historical Trauma—Intergenerational Healing/Indigenous Sovereignty; Social Conditions/Local Context—Thriving Economic and Safe Communities; ACEs—Positive Childhood, Family, and Community Experiences; Disrupted Neurodevelopment—Consistent Corrective Experiences/Cultural Identity Development; Adoption of Health Risk Behaviors—Cultural Values and Coping Skills; Disease Burden and Social Problems—Wellness and Balance; Early Death—Meaningful Life Longevity. We provide examples, supporting research, and implications for implementing the Indigenous Wellness Pyramid.
Inflammatory Profile of Older Adults in Response to Physical Activity and Diet Supplementation: A Systematic Review
Authors: Hernández-Lepe Marco Antonio , Ortiz-Ortiz Melinna , Hernández-Ontiveros David Alfredo , Mejía-Rangel Minerva Janini
Published: February 2023

Chronic, low-grade inflammation in the elderly, usually known as inflammaging, accelerates the development of age-related diseases, including cancer, obesity, sarcopenia, and cardio-metabolic diseases. Two of the most studied interventions against inflammation are diet supplementation and the regular practice of exercise. The search for this systematic review was performed in Scopus, EBSCO, and PubMed databases within the last 10 years. Only randomized controlled trials that evaluated the effect of supplementation and exercise against inflammatory markers in older adults were included. After applying eligibility criteria and risk-of-bias assessment, 11 studies were included in the systematic review. In total, 638 participants were analyzed and the main supplements evaluated were amino acid or protein supplementation from different sources. In the counterpart, the exercise applied in the evaluations included strengthening exercises or aerobic training. The interventions had a range of duration between 4 and 24 weeks, and the effects on inflammation markers in most of the studies showed a decrease in pro-inflammatory cytokines and non- or slightly significant change in anti-inflammatory cytokines. However, these results suggest that exercise and supplement interventions can contribute to diminishing the inflammation process in the elderly. We can also conclude that further well-designed randomized controlled trials are needed to confirm the possible synergistic effects of exercise and food supplementation against inflammation in the elderly due to the limited studies that currently exist. This systematic review was registered in PROSPERO, ID CRD42023387184.
Sense of Belonging, Meaningful Daily Life Participation, and Well-Being: Integrated Investigation
Authors: Haim-Litevsky Dorit , Komemi Reut , Lipskaya-Velikovsky Lena
Published: February 2023

The association between well-being, sense of belonging, connectedness to community, and meaningful participation in daily life occupations was theoretically proved and demonstrated in several health conditions or specific age groups. This study aimed to investigate an interplay between well-being, sense of belonging, and connectedness, and meaningful participation in a range of daily life occupations among healthy adults of working age in Israel. Participants (N = 121; age: M = 30.8, SD = 10.1; women: N = 94, 77.7%) completed standard instruments to evaluate the main constructs through an internet survey. A variety of communities, that the participants reported to belong to, were not different in the sense of belonging and connectedness, participation dimensions, and well-being. An association was found between sense of belonging and connectedness, the participation subjective dimension, and well-being (0.18 < rp < 0.47, p < 0.05). Sense of belonging explained in a significant way the variance in well-being (F(3) = 14.7, p < 0.001; R2 = 0.274) and was found to be a mediator between participation and well-being (1.86 < Sobel test < 2.39, p < 0.05). The study provides empirical support to the interrelationship between meaningful participation, sense of belonging and connectedness, and well-being in a healthy population. Participation in a range of meaningful activities that contribute to the sense of belonging and connectedness as a universal concept could further promote well-being.
Predicting Arm Nonuse in Individuals with Good Arm Motor Function after Stroke Rehabilitation: A Machine Learning Study
Authors: Chen Yu-Wen , Li Yi-Chun , Huang Chien-Yu , Lin Chia-Jung , Tien Chia-Jui , Chen Wen-Shiang , Chen Chia-Ling , Lin Keh-Chung
Published: February 2023

Many stroke survivors demonstrate arm nonuse despite good arm motor function. This retrospective secondary analysis aims to identify predictors of arm nonusers with good arm motor function after stroke rehabilitation. A total of 78 participants were categorized into 2 groups using the Fugl-Meyer Assessment Upper Extremity Scale (FMA-UE) and the Motor Activity Log Amount of Use (MAL-AOU). Group 1 comprised participants with good motor function (FMA-UE ≥ 31) and low daily upper limb use (MAL-AOU ≤ 2.5), and group 2 comprised all other participants. Feature selection analysis was performed on 20 potential predictors to identify the 5 most important predictors for group membership. Predictive models were built with the five most important predictors using four algorithms. The most important predictors were preintervention scores on the FMA-UE, MAL–Quality of Movement, Wolf Motor Function Test-Quality, MAL-AOU, and Stroke Self-Efficacy Questionnaire. Predictive models classified the participants with accuracies ranging from 0.75 to 0.94 and areas under the receiver operating characteristic curve ranging from 0.77 to 0.97. The result indicates that measures of arm motor function, arm use in activities of daily living, and self-efficacy could predict postintervention arm nonuse despite good arm motor function in stroke. These assessments should be prioritized in the evaluation process to facilitate the design of individualized stroke rehabilitation programs to reduce arm nonuse.
Living with Endometriosis: A Narrative Analysis of the Experiences of Kenyan Women
Authors: Bergen Sadie , Murimi Doris , Gruer Caitlin , Munene Gibson , Nyachieo Atunga , Owiti Maureen , Sommer Marni
Published: February 2023

Despite the high global prevalence of endometriosis, little is known about the experiences of women living with the disease in low- and middle-income contexts, including in Kenya and other countries across sub-Saharan Africa. This study captures the perspectives and recommendations of Kenyan women living with endometriosis through written narratives about the impact of the disease on their daily lives and their journeys through diagnosis and treatment. Thirty-seven women between the ages of 22 and 48 were recruited from an endometriosis support group in Nairobi and Kiambu, Kenya (February–March of 2022) in partnership with the Endo Sisters East Africa Foundation. Narrative data (written anonymous stories submitted through Qualtrics) were analyzed using a deductive thematic analysis methodology. Their stories revealed three themes related to their shared experiences with endometriosis: (1) stigma and disruption to quality of life, (2) barriers to acceptable healthcare, and (3) reliance on self-efficacy and social support to cope with the disease. These findings demonstrate a clear need for improved social awareness of endometriosis in Kenya and the establishment of clear, effective, and supportive pathways, with trained, geographically and financially accessible health care providers, for endometriosis diagnosis and treatment.
Life Habits of Healthcare Professionals during the Third Wave of COVID-19: A Cross-Sectional Study in a Spanish Hospital
Authors: Quiroga-Sánchez Enedina , Calvo-Ayuso Natalia , Liébana-Presa Cristina , Trevissón-Redondo Bibiana , Marqués-Sánchez Pilar , Arias-Ramos Natalia
Published: February 2023

(1) Background: To describe sleep quality, eating behaviour and alcohol, tobacco and illicit drug use among healthcare staff in a Spanish public hospital. (2) Methods: Cross-sectional descriptive study examining sleep quality (Pittsburg Sleep Quality Index), eating behaviour (Three Factor Eating Questionnaire (R18)), tobacco and drug use (ESTUDES questionnaire) and alcohol use (Cut down, Annoyed, Guilty, Eye-opener). (3) Results: 178 people, of whom 87.1% (155) were women, with an average age of 41.59 ± 10.9 years. A total of 59.6% of the healthcare workers had sleep problems, to a greater or lesser degree. The average daily consumption was 10.56 ± 6.74 cigarettes. The most commonly used drugs included cannabis, occasionally used by 88.37%, cocaine (4.75%), ecstasy (4.65%) and amphetamines (2.33%). A total of 22.73% of participants had increased their drug use, and 22.73% had increased their consumption during the pandemic, with beer and wine accounting for 87.2% of drinks consumed during this period. (4) Conclusions: In addition to the psychological and emotional impact already demonstrated, the COVID-19 crisis has repercussions on sleep quality, eating behaviour and alcohol, tobacco and drug consumption. Psychological disturbances have repercussions on physical and functional aspects of healthcare workers. It is feasible that these alterations are due to stress, and it is necessary to act through treatment and prevention as well as promote healthy habits.
Reference Values for Sagittal Clinical Posture Assessment in People Aged 10 to 69 Years
Authors: Ludwig Oliver , Dindorf Carlo , Kelm Jens , Simon Steven , Nimmrichter Felix , Fröhlich Michael
Published: February 2023

Poor posture is a well-known problem in all age groups and can lead to back pain, which in turn can result in high socio-economic costs. Regular assessment of posture can therefore help to identify postural deficits at an early stage in order to take preventive measures and can therefore be an important tool for promoting public health. We measured the posture of 1127 symptom-free subjects aged 10 to 69 years using stereophotogrammetry and determined the sagittal posture parameters flèche cervicale (FC), flèche lombaire (FL), and kyphosis index (KI) as well as the values standardized to the trunk height (FC%, FL%, KI%). FC, FC%, KI, and KI% showed an increase with age in men but not in women, and a difference between the sexes. FL remained largely constant with age, although FL% had significantly greater values in women than men. Postural parameters correlated only moderately or weakly with body mass index. Reference values were determined for different age groups and for both sexes. Since the parameters analyzed can also be determined by simple and non-instrumental methods in medical office, they are suitable for performing preventive checks in daily medical or therapeutic practice.
The Global Association between Egg Intake and the Incidence and Mortality of Ischemic Heart Disease—An Ecological Study
Authors: Sugihara Norie , Shirai Yoshiro , Imai Tomoko , Sezaki Ayako , Abe Chisato , Kawase Fumiya , Miyamoto Keiko , Inden Ayaka , Kato Takumi , Sanada Masayo , Shimokata Hiroshi
Published: February 2023

The relationship between egg consumption and ischemic heart disease (IHD) remains controversial as there is still no clear answer regarding the relationship, with research limited to a few geographical regions. In the current study, we conducted a longitudinal analysis of the association between egg intake and IHD incidence (IHDi) and mortality (IHDd) using 28 years of international data from 1990 to 2018. Egg intake (g/day/capita) by country was obtained from the Global Dietary Database. Age-standard IHDi and IHDd rates per 100,000 subjects in each country were obtained from the 2019 Global Burden of Disease database. The analysis included a total of 142 countries with populations of at least one million, for which all data were available from 1990 to 2018. Eggs are consumed worldwide, and regional differences in consumption are also shown. Utilizing IHDi and IHDd as objective variables and egg intake as an explanatory variable, the analysis was conducted using linear mixed models, which controlled for inter- and intra-country variation from year to year. The results showed a significant negative association between egg intake, and IHDi (−0.253 ± 0.117, p < 0.05) and IHDd (−0.359 ± 0.137, p < 0.05). The analysis was carried out using R 4.0.5. The results suggest that adequate egg intake might suppress IHDi and IHDd on a global scale.
Homotypical and Heterotypical Intergenerational Continuity of Child Maltreatment: Evidence from a Cohort of Families Involved with Child Protection Services
Authors: Langevin Rachel , Kern Audrey , Esposito Tonino , Hélie Sonia
Published: February 2023

Child maltreatment (CM) in one generation can predict CM in the next generation, a concept known as intergenerational continuity. Yet, the form taken by the intergenerational continuity of CM remains unclear and fathers are mostly absent from this literature. This longitudinal study aimed to document patterns of intergenerational continuity of substantiated CM, on the maternal and paternal sides, by examining the presence of: homotypical CM, which is the same type of CM in both generations; and heterotypical CM, which is different CM types in both generations. The study included all children substantiated for CM with the Centre Jeunesse de Montréal between 1 January 2003, and 31 December 2020, with at least one parent who was also reported to that agency during their childhood (n = 5861 children). The cohort was extracted using clinical administrative data, and logistic regression models were tested with the children’s CM types as the dependent variables. Homotypical continuity was found for: (1) physical abuse on the paternal side; (2) sexual abuse on the maternal side; and (3) exposure to domestic violence on the maternal side. Heterotypical continuity was also prevalent, but to a lesser extent. Interventions helping maltreated parents overcome their traumatic past are essential to foster intergenerational resilience.
Association between Sarcopenia, Falls, and Cognitive Impairment in Older People: A Systematic Review with Meta-Analysis
Authors: Fhon Jack Roberto Silva , Silva Alice Regina Felipe , Lima Eveline Fontes Costa , Santos Neto Alexandre Pereira dos , Henao-Castaño Ángela Maria , Fajardo-Ramos Elizabeth , Püschel Vilanice Alves Araújo
Published: February 2023

With the aging process, elderly people present changes in their bodies that can lead them to suffer several geriatric syndromes. The present study aimed to analyze and synthesize the literature produced concerning the association of sarcopenia with falls in elderly people with cognitive impairment. This is a systematic review study on etiology and risk, conducted according to the JBI methodology using the Medline (Pubmed), Cinahl, Embase, Scopus, and Web of Science databases. The gray literature search was conducted in the CAPES Brazilian Digital Library of Theses and Dissertations, Google Scholar, Networked Digital Library of Theses and Dissertations (NDLTD), EBSCO Open Dissertations, DART-e, and ACS Guide to Scholarly Communication. The identification of the association between the variables was extracted from the articles themselves (Odds Ratio and the 95% Confidence Intervals). Four articles published between 2012 and 2021 were included in this review. A prevalence of falls was identified, ranging from 14.2% to 23.1%, of cognitive impairment ranging from 24.1% to 60.8%, and of sarcopenia ranging from 6.1 to 26.6%. The meta-analysis found that elderly people with cognitive impairment who suffer falls are at a 1.88 times greater risk of presenting sarcopenia (p = 0.01). There is evidence of an association between the variables, but it is necessary to conduct follow-up studies to support this association as well as other factors that may influence the senescence and senility process.
Body Loading during an Intensive Yoga Exercise Routine and a Cycle Ergometer Test
Authors: Stec Krzysztof , Pilis Karol , Pilis Wiesław , Miodek Przemysław , Pilis Anna , Letkiewicz Sławomir
Published: February 2023

The present study compared the effects on the cardiovascular, respiratory, and metabolic functions of the practice of an intensive yoga exercise routine called Dynamic Suryanamaskar (DSN) and a cycle ergometer test (CET) of increasing intensity. The study involved 18 middle-aged volunteers who had previously practiced DSN. The study was conducted in two series (i.e., as CET and DSN with similar intensity) until complete exhaustion. At rest (R), at the ventilatory anaerobic threshold (VAT), and at the maximum workload (ML), the variables characterizing cardiovascular, respiratory, and metabolic functions were determined. In addition, the subjective intensity of both efforts was determined using the Borg test. No functional differences were observed in the cardiovascular, respiratory, and metabolic systems at similar CET and DSN intensities. Respondents experienced less subjective workload during DSN than during CET (p < 0.001). Since DSN intensifies the activity of the cardiovascular, respiratory, and metabolic systems to a similar degree to CET both at VAT and ML, but causes less subjective fatigue, this yogic practice can be used as a laboratory exercise test and as an effective training medium.
Adaptation and Validation of the Lithuanian Version of the Sport-Specific Doping Self-Regulatory Efficacy Scale
Authors: Sukys Saulius , Hoppen Beatrice
Published: February 2023

Background: Use of banned performance enhancing substances in sport is one of the most widely recognized anti-doping rules violation. Research evidence suggests that self-regulatory efficiency is one of the key psychosocial processes related with doping. Therefore, aiming to generate more insights on the self-regulatory efficacy, sport-specific doping self-regulatory efficacy scale was proposed. The aim of the present study was to adapt and validate the Lithuanian version of the sport-specific doping self-regulatory efficacy scale. Material and Methods: The scale construct validity and reliability was tested using a sample of 453 athletes (mean age 20.37, SD = 2.29; 46% male). Structural validity was assessed by exploratory and confirmatory factor analyses, convergent and discriminant validity of the scale were evaluated by assessing average variance extracted and also via correlational analyses. Cronbach’s alpha and composite reliability values were used for reliability analysis. Results: Exploratory and confirmatory factor analyses confirmed the one factor structure of the sport-specific doping self-regulatory efficacy scale. The results also indicated that the scale had sufficient convergent and discriminant validity. The results showed an excellent level of internal consistency. Conclusions: This study makes a contribution by confirming the validity and reliability of the Lithuanian version of the sport-specific doping self-regulatory efficacy scale.
Induction of Apoptosis and Decrease of Autophagy in Colon Cancer Cells by an Extract of Lyophilized Mango Pulp
Authors: Lozano-Casabianca Gustavo Argenor , Arango-Varela Sandra Sulay , Maldonado-Celis María Elena
Published: February 2023

Previous studies have indicated that mango fruit has a chemopreventive capacity against colorectal cancer cells. The objective of this research was to evaluate the effect of an aqueous extract of lyophilized mango pulp (LMPE) on colon adenocarcinoma cells (SW480) and their metastatic derivatives (SW620) death and cellular invasion. DNA fragmentation was assessed by TUNEL assay; autophagy and expression of DR4 and Bcl-2 by flow cytometry; the expression of 35 apoptosis-related proteins and of matrix metalloproteinases 7 and 9 by immunodetection; and the invasive capacity of the cells by Boyden chamber. The results showed that LMPE at 30 mg/mL and 48 h of exposure results in DNA fragmentation and apoptosis in SW480 (p < 0.001) and SW620 (p < 0.01) cells. Additionally, LMPE decreased autophagy in the SW480 and SW620 cell lines (p < 0.001), which could sensitize them to the DNA damage generated by LMPE. The LMPE did not modulate the expression of matrix metalloproteinases 7 and 9, nor did it affect cellular invasion processes in the SW480 and SW620 cell lines. In conclusion, LMPE induces apoptosis and decreases autophagy in SW480 and SW620 cells.
Association of Rheumatoid Arthritis with Opioid Pain Medication Overuse among Persons Exposed to the 9/11 World Trade Center Disaster
Authors: Dhanya Ananya Sarker , Yung Janette , Cone James E. , Li Jiehui
Published: February 2023

We examined the association of post-9/11 rheumatoid arthritis (RA) diagnosis with opioid pain medication overuse among enrollees in the World Trade Center Health Registry (WTCHR). Opioid overuse was defined as the self-reported intake of prescribed opioids at a higher dosage or more often than directed in the last 12 months on one of the two most recent WTCHR surveys (2015–2016, 2020–2021). Post-9/11 RA was ascertained through self-reports and subsequently validated following medical record release by the enrollees’ physicians or medical records review. We excluded those with self-reported RA that was not validated by their physicians and those who did not report being prescribed opioid pain medication in the last 12 months. Multivariable log-binomial regression was conducted to examine the relationship between post-9/11 RA diagnosis and opioid pain medication overuse, adjusting for sociodemographic characteristics and 9/11-related posttraumatic stress disorder (PTSD) symptoms. Of the 10,196 study enrollees, 46 had confirmed post-9/11 RA. The post-9/11 RA patients were mostly females (69.6% vs. 37.7%), less frequently non-Hispanic White (58.7% vs. 73.2%) individuals, and less often had attained a higher level of education (76.1% vs. 84.4%) compared to those without post-9/11 RA. Opioid pain medication overuse was significantly associated with a post-9/11 RA diagnosis (Adjusted Risk Ratio: 2.13, 95% CI: 1.44–3.17). More research is needed to better understand the use and management of prescribed opioids among WTC-exposed individuals with RA.
Risk Factors of Microalbuminuria among Patients with Type 2 Diabetes Mellitus in Korea: A Cross-Sectional Study Based on 2019–2020 Korea National Health and Nutrition Examination Survey Data
Authors: Bae Eun Sook , Hur Jung Yi , Jang Hyung Soon , Kim Jeong Suk , Kang Hye Seung
Published: February 2023

Diabetes mellitus is a chronic disease with high economic and social burdens. This study aimed to determine the risk factors of microalbuminuria among patients with type 2 diabetes mellitus. Microalbuminuria is predictive of early-stage renal complications and subsequent progression to renal dysfunction. We collected data on type 2 diabetes patients who participated in the 2019–2020 Korea National Health and Nutrition Examination Survey. The risk factors for microalbuminuria among patients with type 2 diabetes were analyzed using logistic regression. As a result, the odds ratios were 1.036 (95% confidence interval (CI) = 1.019–1.053, p < 0.001) for systolic blood pressure, 0.966 (95% CI = 0.941–0.989, p = 0.007) for high-density lipoprotein cholesterol level, 1.008 (95% CI = 1.002–1.014, p = 0.015) for fasting blood sugar level, and 0.855 (95% CI = 0.729–0.998, p = 0.043) for hemoglobin level. A significant strength of this study is the identification of low hemoglobin level (i.e., anemia) as a risk factor for microalbuminuria in patients with type 2 diabetes. This finding implies that the early detection and management of microalbuminuria can prevent the development of diabetic nephropathy.
“My [Search Strategies] Keep Missing You”: A Scoping Review to Map Child-to-Parent Violence in Childhood Aggression Literature
Authors: Rutter Nikki
Published: February 2023

Child-to-parent violence is often referred to as one of the most ‘under-researched’ forms of family violence. However, it is closely associated with one of the most widely researched areas of research globally: childhood aggression. How child-instigated aggression can harm parents is widely referred to, but different framings, definitions, and conceptualisations are used which creates problems when attempting to identify the broader literature which may be relevant to child-to-parent violence researchers. Methods: Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews, 55 papers were reviewed from EBSCO, PubMed, SCOPUS, and Web of Science to explore how location, field of the researcher, and terminology can impact how researchers conceptualise and frame this form of harm. Results: Three themes were identified (1) child-to-parent violence is a behavioural indicator of childhood distress or developmental needs, (2) children are ‘perpetrators’ of deviant behaviour, and (3) the parents are ‘victims’ of child-to-parent violence. Conclusions: Children and parents are both harmed by child-to-parent violence. It is important that future researchers and practitioners recognise the bi-directionality of the parent-child relationship, and not be complicit in hiding the harms caused by child-to-parent violence by subsuming it under the broader childhood aggression literature.
Effects of Virtual Reality Exercise Program on Blood Glucose, Body Composition, and Exercise Immersion in Patients with Type 2 Diabetes
Authors: Lee Yu-jin , Hong Jun-hwa , Hur Myung-haeng , Seo Eun-young
Published: February 2023

Background: This study is a preliminary study to examine the effect of a virtual reality exercise program (VREP) on type 2 diabetes patients. Method: This is a randomized controlled trial for patients with type 2 diabetes (glycated hemoglobin ≥ 6.5%), diagnosed by a specialist. The virtual reality environment was set up by attaching an IoT sensor to an indoor bicycle and linking it with a smartphone, enabling exercise in an immersive virtual reality through a head-mounted display. The VREP was implemented three times a week, for two weeks. The blood glucose, body composition, and exercise immersion were analyzed at baseline, and two weeks before and after the experimental intervention. Result: After VREP application, the mean blood glucose (F = 12.001 p < 0.001) and serum fructosamine (F = 3.274, p = 0.016) were significantly lower in the virtual reality therapy (VRT) and indoor bicycle exercise (IBE) groups than in the control group. There was no significant difference in the body mass index between the three groups; however, the muscle mass of participants in the VRT and IBE groups significantly increased compared with that of the control (F = 4.445, p = 0.003). Additionally, exercise immersion was significantly increased in the VRT group compared with that in the IBE and control groups. Conclusion: A two week VREP had a positive effect on blood glucose, muscle mass, and exercise immersion in patients with type 2 diabetes, and is highly recommended as an effective intervention for blood glucose control in type 2 diabetes.
Evaluation of Satisfaction with the Built Environment of University Buildings under the Epidemic and Its Impact on Student Anxiety
Authors: Wen Qiang , Liu Haiqiang , Chen Jinyuan , Ye Huiyao , Pan Zeyu
Published: February 2023

Anxiety on college campuses has increased due to the COVID-19 epidemic’s profound effects on society. Much research has been conducted on how the built environment influences mental health; however, little has been undertaken on how it affects student mental health in the context of the epidemic from the architectural scale perspective of academic buildings. Based on online survey data, this study develops multiple linear regression and binary logistic regression models to investigate students’ satisfaction ratings of the academic buildings’ physical environments during the epidemic and how these satisfaction ratings affect students’ anxiety tendencies. According to the study’s findings regarding the natural exposure perspective, students who perceived the academic building’s poor semi-open space view (p = 0.004, OR = 3.22) as unsatisfactory factors were more likely to show anxiety tendencies. In terms of the physical conditions, students who were dissatisfied with the noise level in the classroom (p = 0.038, OR = 0.616) and the summer heat in semi-open spaces (p = 0.031, OR = 2.38) were more likely to exhibit anxiety tendencies. Additionally, even after controlling for confusing distractions, the general satisfaction rating of the academic building’s physical environments (p = 0.047, OR = 0.572) was still able to significantly and negatively affect students’ anxiety tendencies. The study’s findings can be used in the architectural and environmental planning of academic buildings focusing on mental health.
Spatiotemporal Changes in Frost-Free Season and Its Influence on Spring Wheat Potential Yield on the Qinghai–Tibet Plateau from 1978 to 2017
Authors: Zhang Zemin , Lu Changhe
Published: February 2023

Accurately assessing the variation in the frost-free season (FFS) can provide decision support for improving agricultural adaptability and reducing frost harm; however, related studies were inadequate in terms of the Qinghai–Tibet Plateau (QTP). This study analyzed the spatiotemporal changes in the first frost day in autumn (FFA), last frost day in spring (LFS), FFS length and effective accumulated temperature (EAT) during the 1978–2017 period, and their influences on spring wheat potential yield on the QTP, based on daily climatic data and the methodology of Sen’s slope and correlation analysis. The results showed that the annual average FFA and LFS occurred later and earlier from northwest to southeast, respectively, and both the FFS length and EAT increased. From 1978 to 2017, the average regional FFA and LFS were delayed and advanced at rates of 2.2 and 3.4 days per decade, and the FFS and EAT increased by 5.6 days and 102.7 °C·d per decade, respectively. Spatially, the increase rate of FFS length ranged from 2.8 to 11.2 days per decade throughout the QTP, and it was observed to be larger in northern Qinghai, central Tibet and Yunnan, and smaller mainly in eastern Sichuan and southern Tibet. Correspondingly, the increase rate for EAT ranged from 16.2 to 173.3 °C·d per decade and generally showed a downward trend from north to south. For a one-day increase in the FFS period, the spring wheat potential yield would decrease by 17.4 and 9.0 kg/ha in altitude ranges of <2000 m and 2000–3000 m, but decrease by 24.9 and 66.5 kg/ha in the ranges of 3000–4000 m and >4000 m, respectively. Future studies should be focused on exploring the influence of multiple climatic factors on crop production using experimental field data and model technologies to provide policy suggestions.
The Effects of Subjective Social Class on Subjective Well-Being and Mental Health: A Moderated Mediation Model
Authors: Li Kai , Yu Feng , Zhang Yanchi , Guo Yongyu
Published: February 2023

In recent decades, China’s rapid economic growth has substantially improved average living standards; however, this has not been accompanied by greater happiness among the Chinese population. This phenomenon is known as the Easterlin Paradox (i.e., there is no link between a society’s economic development and its average level of happiness) in Western countries. This study examined the effects of subjective social class on subjective well-being and mental health in China. Consequently, we found that individuals in a relatively low social class had lower levels of subjective well-being and mental health; self-class discrepancy partially explains the relationship between subjective social class and subjective well-being and fully explains the relationship between subjective social class and mental health; and subjective social mobility moderates the path from self-class discrepancy to subjective well-being and mental health. These findings suggest that enhancing social mobility is an important method for reducing class differences in subjective well-being and mental health. These results have important implications, indicating that enhancing social mobility is an important method for reducing class differences in subjective well-being and mental health in China.
Crash Risk Predictors in Older Drivers: A Cross-Sectional Study Based on a Driving Simulator and Machine Learning Algorithms
Authors: Silva Vanderlei Carneiro , Dias Aluane Silva , Greve Julia Maria D’Andréa , Davis Catherine L. , Soares André Luiz de Seixas , Brech Guilherme Carlos , Ayama Sérgio , Jacob-Filho Wilson , Busse Alexandre Leopold , de Biase Maria Eugênia Mayr , Canonica Alexandra Carolina , Alonso Angelica Castilho
Published: February 2023

The ability to drive depends on the motor, visual, and cognitive functions, which are necessary to integrate information and respond appropriately to different situations that occur in traffic. The study aimed to evaluate older drivers in a driving simulator and identify motor, cognitive and visual variables that interfere with safe driving through a cluster analysis, and identify the main predictors of traffic crashes. We analyzed the data of older drivers (n = 100, mean age of 72.5 ± 5.7 years) recruited in a hospital in São Paulo, Brazil. The assessments were divided into three domains: motor, visual, and cognitive. The K-Means algorithm was used to identify clusters of individuals with similar characteristics that may be associated with the risk of a traffic crash. The Random Forest algorithm was used to predict road crash in older drivers and identify the predictors (main risk factors) related to the outcome (number of crashes). The analysis identified two clusters, one with 59 participants and another with 41 drivers. There were no differences in the mean of crashes (1.7 vs. 1.8) and infractions (2.6 vs. 2.0) by cluster. However, the drivers allocated in Cluster 1, when compared to Cluster 2, had higher age, driving time, and braking time (p < 0.05). The random forest performed well (r = 0.98, R2 = 0.81) in predicting road crash. Advanced age and the functional reach test were the factors representing the highest risk of road crash. There were no differences in the number of crashes and infractions per cluster. However, the Random Forest model performed well in predicting the number of crashes.
Dynamic Response and Adaptation of Grassland Ecosystems in the Three-River Headwaters Region under Changing Environment: A Review
Authors: Kou Yaowen , Yuan Quanzhi , Dong Xiangshou , Li Shujun , Deng Wei , Ren Ping
Published: February 2023

The Three-River Headwaters Region (TRHR) is crucial to the sustainable development of China and Southeast Asia. The sustainability of grassland ecosystems in the region has been seriously challenged in recent years. This paper reviewed the changes in the grasslands of the TRHR and their responses to climate change and human activities. The review showed that accurate monitoring of grassland ecological information is the basis for effective management. Although alpine grassland coverage and the above-ground biomass of the alpine grassland have generally increased in the region over the past 30 years, the degradation has not been fundamentally curbed. Grassland degradation substantially reduced topsoil nutrients and affected their distribution, deteriorated soil moisture conditions, and aggravated soil erosion. Grassland degradation led to loss of productivity and species diversity, and this is already harming the well-being of pastoralists. The “warm and wet” trend of the climate promoted the restoration of alpine grasslands, but widespread overgrazing is considered as one of the main reasons for grassland degradation, and related differences still exist. Since 2000, the grassland restoration policy has achieved fruitful results, but the formulation of the policy still needs to integrate market logic effectively and strengthen the understanding of the relationship between ecological protection and cultural protection. In addition, appropriate human intervention mechanisms are urgently needed due to the uncertainty of future climate change. For mildly and moderately degraded grassland, traditional methods are applicable. However, the severely degraded “black soil beach” needs to be restored by artificial seeding, and the stability of the plant–soil system needs to be emphasized to establish a relatively stable community to prevent secondary degradation.
Building a City with Low Noise Pollution: Exploring the Mental Health Effect Thresholds of Spatiotemporal Environmental Noise Exposure and Urban Planning Solution
Authors: Zhang Xue , Zhou Suhong
Published: February 2023

Urban noise pollution and health hazards have become serious social problems and challenges. Noise prevention and control is the most cost-effective health strategy. However, in urban planning and noise control, reliable evidence is still lacking on individual spatiotemporal environmental noise exposure and its mental health effects. This study used real-time noise exposure data and GPS trackers from 142 volunteers aged 18 to 60 years in Guangzhou, and further analyzed the differences in environmental noise exposure and its mental health impact thresholds under individual spatiotemporal behavior. The results showed that the noise exposure of residents under daily activities has obvious differences in time, space and place. Regarding the threshold relationship between noise exposure and mental health, noise exposure at night, work, personal affairs, travel and sleep activities, as well as at home and work had a threshold effect on residents’ mental health. Noise thresholds were 60 dB, 60 dB, and about 34 dB at night, during work or at a workplace, and while sleeping, respectively. The optimal sound environment for personal affairs, traveling, and at home was around 50 dB, 55–70 dB, and 45 dB, respectively. The environmental noise exposure assessment and mental health impact threshold analysis based on the spatial and temporal activities of individuals will provide important reference for government management departments in planning and policy formulation.
SWATH-MS-Based Proteomics Reveals the Regulatory Metabolism of Amaryllidaceae Alkaloids in Three Lycoris Species
Authors: Tang Meng , Li Chaohan , Zhang Cheng , Cai Youming , Zhang Yongchun , Yang Liuyan , Chen Moxian , Zhu Fuyuan , Li Qingzhu , Li Kehu
Published: February 2023

Alkaloids are a class of nitrogen-containing alkaline organic compounds found in nature, with significant biological activity, and are also important active ingredients in Chinese herbal medicine. Amaryllidaceae plants are rich in alkaloids, among which galanthamine, lycorine, and lycoramine are representative. Since the difficulty and high cost of synthesizing alkaloids have been the major obstacles in industrial production, particularly the molecular mechanism underlying alkaloid biosynthesis is largely unknown. Here, we determined the alkaloid content in Lycoris longituba, Lycoris incarnata, and Lycoris sprengeri, and performed a SWATH-MS (sequential window acquisition of all theoretical mass spectra)-based quantitative approach to detect proteome changes in the three Lycoris. A total of 2193 proteins were quantified, of which 720 proteins showed a difference in abundance between Ll and Ls, and 463 proteins showed a difference in abundance between Li and Ls. KEGG enrichment analysis revealed that differentially expressed proteins are distributed in specific biological processes including amino acid metabolism, starch, and sucrose metabolism, implicating a supportive role for Amaryllidaceae alkaloids metabolism in Lycoris. Furthermore, several key genes collectively known as OMT and NMT were identified, which are probably responsible for galanthamine biosynthesis. Interestingly, RNA processing-related proteins were also abundantly detected in alkaloid-rich Ll, suggesting that posttranscriptional regulation such as alternative splicing may contribute to the biosynthesis of Amaryllidaceae alkaloids. Taken together, our SWATH-MS-based proteomic investigation may reveal the differences in alkaloid contents at the protein levels, providing a comprehensive proteome reference for the regulatory metabolism of Amaryllidaceae alkaloids.