bluuebunny/crossref_metadata_2025 huggingface dataset:
Restructuring the Digital Systems Laboratory in Computer Engineering Course
Authors: Lima Kollins Gabriel , Luppe Maximiliam
Published: December 2018

It's not difficult to find students of Computer Engineering, at the University of São Paulo, in São Carlos School of Engineering, complaining about the way that practical classes are given during the graduation. What is said is that these classes only reproduce results already seen in theory classes, that they are limited by a laboratory script and, at the end, nothing new is added to their knowledge, making them a little bit frustrated about the classes. In this paper, it's shown how PBL (Problem-based Learning) was used in Digital Systems Laboratory, a 4-semester discipline, to start a change in this situation. The main purpose of the project was to use all the knowledge in digital logic, already seen in theory classes by the students, to build the main modules of a basic processor: arithmetic logic unit (ALU), for combinational logic studies; register bank, for sequential logic studies; and control unity, used to study finite state machines. This new way to teach each topic of the discipline brought new challenges to the students, now free to solve them the way they wanted to, once only the specification of inputs and outputs were given. Using FPGA boards and circuit simulators for development, the students succeeded in their task and the modules were built and tested in a test platform, developed to allow the simulation of the entire processor. This project had a positive feedback, either reflected in grades (in laboratory and in related theoretical disciplines) and also in the student's motivation (although some difficulties was found) helping them to understand how different concepts seen during the graduation course are related. This feedback is now helping the development of a new material for next classes, in order to make specifications clearer, correct bugs in the test platform and improve some features for debug.
Can Bloom and Kolb’s Ideas Help Us Reproduce Positive Experiences in Using Teaching Practices to Promote the Development of Active Learning in the Classroom?
Authors: Tavares Samuel
Published: December 2018

This paper sought to find out how teaching techniques and procedures can work synergically to promote the development of active learning in the classroom, aiming to contribute to the consolidation of a scientific basis, both in its concrete application and theoretical foundation, by examining the practices of 11 engineering teachers, from three Brazilian universities located in São Paulo, whose classes were drawing attention from their course coordinators, due to the positive impact on their students’ learning, and who agreed to talk about their ideas and actions. The main research question was "Can Bloom and Kolb’s Ideas Help Us Reproduce Positive Experiences in Using Teaching Practices to Promote the Development of Active Learning in the Classroom? ". In face of the examined data, the answer to this question is “YES”, as shown in Figure 7.
Case Study: Electrical Engineering Introduction Course Using An Integrated Approach Via Group Work Viability Projects
Authors: Prado Renan Luis , Ribeiro Paulo , Castelo Tiago
Published: December 2018

This paper discuss an innovative teaching methodology applied in a university sited in Minas Gerais, Brazil. The main goal is to reduce the dropout rate in Engineering Courses. The Federal University of Itajubá (UNIFEI) offers freshmen students a new perspective about the Electrical Engineering course, showing them the vast possibilities it might lead them. For that, the university uses the course called Introduction to Electrical Engineering, based in the formation of groups focused in the study of the viability of Renewable Energy Sources projects. Differently from the traditional method, where the students are merely “recipients” meant to be filled by the teacher (LEWIS, 1939), the idea is to concede a chance for the pupils, allowing them to guide their researches and activities based on their needs. In this context, a group called Photovoltaic Application in Needy Communities (PANC), from the 2015 class, reached at the end of the period the implantation of the group’s objective: a solar system in a Basic Health Center in Itajubá (MG). The methods applied by the group are discussed in this paper.
ANÁLISE DAS PRESCRIÇÕES DE SIBUTRAMINA EM DROGARIA
Authors: Maschio de Lima Tiago Aparecido , Franco Thaisa Ferreira , Pereira Luis Lênin Vicente , Godoy Moacir Fernandes de
Published: December 2018

Introdução: A sibutramina é um fármaco anorexígeno amplamente utilizado no tratamento da obesidade. No entanto, seu uso indiscriminado está relacionado à ocorrência de reações adversas, principalmente de origem cardiovascular. Objetivo: Analisar as prescrições de sibutramina em uma drogaria. Metodologia: Trata-se de um estudo retrospectivo e descritivo exploratório. Analisou-se 240 notificações de receita B2 e Termos de Responsabilidade do Prescritor referentes ao ano de 2016. Resultados: A maioria das notificações foi destinada ao gênero feminino (93%) e com média de idade de 38±12 anos. A obesidade sem grau especificado foi a justificativa presente em 82% dos termos. A endocrinologia foi a especialidade mais envolvida nas prescrições (70%), seguido pela Clínica Geral (16%). A nomenclatura comercial esteve presente em 89% das prescrições, sendo que 6% foram advindas do serviço público de saúde. As inconsistências identificadas foram omissão da idade (83%), ausência da justificativa (6%) e prescrição fora da faixa etária permitida pela legislação vigente. Conclusão: Observa-se inconsistências relacionadas à omissão de idade, justificativa de uso, utilização contraindicada em idosos e adolescentes, prescrição por profissionais não especializados, e utilização de nome comercial no sistema público de saúde. Reforça-se a importância do farmacêutico na análise criteriosa os documentos necessários para a dispensação da sibutramina.
Pureza e natureza na “Cantate du Narcisse”, de Paul Valéry
Authors: Lemos Rodrigo De Oliveira
Published: December 2018

Neste trabalho, abordaremos a “Cantate du Narcisse”, de Paul Valéry (1871-1945), a partir de um estudo de seu protagonista, Narciso. Em primeiro lugar, deter-nos-emos sobre a tessitura sonora do verso e seu cuidado com o equilíbrio composicional. Voltar-nos-emos, então, à relação do protagonista com as ninfas e à sua oposição aos deuses que o condenam por seu amor desmesurado. Mostraremos, então, como a figura de Narciso da “Cantate” manifesta um dos temas caros a Valéry (a busca pela pureza em oposição à natureza), preocupação que surge em outros momentos de sua obra.
Antonio Candido e a conciência do atraso
Authors: Franchetti Paulo
Published: December 2018

Descrevem-se neste trabalho algumas inflexões da obra de Antonio Candido: num primeiro momento, apresenta-se a sua perspectiva histórica da literatura e da cultura brasileira nos anos do desenvolvimentismo (década de 1950), que apontava para a integração do Brasil no concerto das nações civilizadas; num segundo, descreve-se o impacto do golpe militar de 1964 no pensamento do autor e as alterações na sua percepção quanto à modernização do país e o lugar a ele reservado na ordem capitalista mundial; por fim, em decorrência desse impacto, discute-se a valorização do popular na avaliação de algumas obras do século XIX, bem como a correlata expectativa de realização de uma transformação cultural e política do país por meio de uma grande aliança, um grande pacto nacional.
O funcionamento dos elementos adverbiais no gênero textual propaganda
Authors: Santos Diana Rodrigues Sarcinelli dos , Rocha Lúcia Helena Peyroton da
Published: December 2018

Neste artigo objetivamos analisar qualitativamente e quantitativamente os elementos de natureza adverbial em propagandas da rede Hortifruti, para discutir a noção de dispensabilidade dada a esses elementos pelos estudos tradicionais, que os classificam como termos acessórios da oração sob uma ótica sintático-semântica, e evidenciar sua importância para o cumprimento do propósito comunicativo desse gênero textual. Partimos do pressuposto de que a motivação para o uso dos elementos adverbiais está condicionada a aspectos pragmático-discursivos. Recorremos, pois, à orientação teórica do Funcionalismo de vertente norte-americana (GIVÓN, 2001; TOMASELLO, 1998), conjugando-a com a Linguística Textual (KOCH, 2014; CAVALCANTE; CUSTÓDIO FILHO, 2010).
Distinguishing between Theory, Theoretical Framework, and Conceptual Framework: A Systematic Review of Lessons from the Field
Authors: Kivunja Charles
Published: December 2018

Across many years of teaching Research Methods and assessing many applications for admission into higher degree studies which require an understanding of theories, principles, strategies and skills needed to complete a higher degree such as a Masters or a PhD, one of the things I have found problematic for many students is the inability to articulate differences between theory, theoretical framework and a conceptual framework for a proposed research project. This paper uses experiential methodology to draw upon my experience in practice, and systematic literature review methodology to draw upon supporting scholarly literature by leaders in the field, to contribute to existing knowledge on the meaning of each of these concepts, and more importantly to distinguish between them in a study of Research Methods, and in particular as they relate to designing a research proposal and a thesis for a higher degree. The primary aim is to help the reader develop a firm grasp of the meaning of these concepts and how they should be used in academic research discourses. The review answers five questions. 1. What does each of these terms mean? 2. When and how should each be used? 3. What purposes does a theoretical framework serve? 4. How do you develop a theoretical framework for your research proposal or thesis? 5. What does a good theoretical framework look like?
The Effect of Motivation and Self-Efficacy on Math Studies in the Israeli Ministry of Education's Program "Give Five"
Authors: Davidovitch Nitza , Yavich Roman
Published: December 2018

Studying mathematics is an essential condition for acquiring an education in most fields such as all exact sciences, financial sphere, programming, etc. It enables students to choose from among a large variety of professions with significantly high chances of academic admission, mainly in fields such as engineering, natural sciences, and technology, as well as in a considerable part of the social sciences Hence, studying mathematics in high school is a critical and key factor for continued studies and for integration in many professions in the Israeli workforce. The current study sought to expand knowledge on the effect of students' psychological feelings, such as motivation and self-efficacy, in light of the "Give Five" reform initiated by the Ministry of Education implemented in 2015. The study examined the effects of the "Give Five" reform on student motivation and self-efficacy, while examining whether these influences were gender-dependent. The study confirmed a positive correlation between the degree of motivation to study mathematics and the level of self-efficacy, and no difference was found between males and females in their level of motivation and self-efficacy. Future recommendations include research into the significance of motivation and self-efficacy as a major determinant of scholastic success.
Reviewer Acknowledgements for Environment and Natural Resources Research, Vol. 8, No. 4
Authors: Lin Emily
Published: December 2018

Reviewer Acknowledgements for Environment and Natural Resources Research, Vol. 8, No. 4, 2018
TESTING A PROTOTYPE FRICTION DRIVE TRANSMISSION
Authors: MUCHA Łukasz , LIS Krzysztof , LEHRICH Krzysztof , NAWRAT Zbigniew
Published: December 2018

The article presents research on the mechanical properties of a drive system using an innovative mechanism converting rotary motion to progressive motion. The operating principle of the mechanism uses the friction-based transmission of drive from the motor to the drive shaft by means of two oppositely arranged unidirectional clutches. A side effect of such a solution utilized in the mechanism is the possibility of shifting the couplings while transmitting torque. The clutches were combined with a mechanism converting rotational motion to linear motion by utilizing friction between radial ball bearings and the shaft. This has resulted in an innovative mechanism for converting rotary motion to progressive motion, with the drive source being bound with a “friction screw” (a “slide” screw). A characteristic feature of this solution is the fact that there is no need for the nut to rotate in order to achieve progressive movement. Known solutions are based on a rotating nut and a fixed shaft system. The mechanism uses a fixed pitch nut, but it is possible to use a regulated pitch nut as a possible modification of the mechanism at a later stage of the system development. The main advantage of the mechanism tested is the possibility of uncoupling, which occurs when the maximum force transmitted by the nut is exceeded. This force is related to the friction force resulting from the pressure exerted by angularly shifted ball bearings on the drive shaft. The bearings are a substitute for the screw line in the classical ball screw mechanism. The research results presented in the article give an overview of the mechanical properties of the solution developed. The article also presents the influence of rotational speed and load on the mechanical parameters of the drive. The application of the described invention as the basis of the linear motion mechanism driving the tool of a surgical robot is a safe solution with unique and desirable characteristics.
HYDROSTATIC THRUST BEARING WITH REDUCED POWER LOSSES
Authors: WASILCZUK Filip , WASILCZUK Michał , WODTKE Michał
Published: December 2018

In many cases in rotating machinery, axial load is carried by tilting pad thrust bearings which have been developed since the beginning of 20th century. For high reliability and simplicity, most commonly the bearings are bath lubricated. In the times of sustainable development, however, minimization of friction losses becomes an important criterion for machinery assessment, and a strategic goal of their development. Performed calculations, based on elementary rules of fluid dynamics, showed that shearing losses in specially designed hydrostatic bearings can be considerably smaller than the losses in tilting pad hydrodynamic bearings. The aim of the research described in this paper was to check if the preliminary results presented earlier and conclusions of benefits of the further increase of the size of the hydrostatic pocket can be confirmed with the use of CFD calculations.
On the value of preprints: an early career researcher perspective
Authors: Sarabipour Sarvenaz , Debat Humberto J , Emmott Edward , Burgess Steven , Schwessinger Benjamin , Hensel Zach
Published: December 2018

Peer-reviewed journal publication is the main means for academic researchers in the life sciences to create a permanent, public record of their work. These publications are also the de facto currency for career progress, with a strong link between journal brand recognition and perceived value. The current peer-review process can lead to long delays between submission and publication, with cycles of rejection, revision and resubmission causing redundant peer review. This situation creates unique challenges for early career researchers (ECRs), who rely heavily on timely publication of their work to gain recognition for their efforts. ECRs face changes in the academic landscape including the increased interdisciplinarity of life sciences research, expansion of the researcher population and consequent shifts in employer and funding demands. The publication of preprints, publicly available scientific manuscripts posted on dedicated preprint servers prior to journal managed peer-review, can play a key role in addressing these ECR challenges. Preprinting benefits include rapid dissemination of academic work, open access, establishing priority or concurrence, receiving feedback and facilitating collaborations. While there is a growing appreciation for and adoption of preprints, a minority of all articles in life sciences and medicine are preprinted. The current low rate of preprint submissions in life sciences and ECR concerns regarding preprinting needs to be addressed. We provide a perspective from an interdisciplinary group of early career researchers on the value of preprints and advocate the wide adoption of preprints to advance knowledge and facilitate career development.
Model Kepemimpinan Servant Paling Dominan Berhubungan dengan Kinerja
Authors: Rayatin Lilis
Published: December 2018

Model kepemimpinan kepala ruangan dapat meningkatkan kinerja perawat pelaksana dalam memberikan asuhan keperawatan. Tujuan penelitian ini adalah untuk mengidentifikasi hubungan antara model kepemimpinan kepala ruangan dengan kinerja perawat pelaksana. Metode penelitian menggunakan cross sectional, dengan melibatkan 141 responden di sebuah RS. Instrumen yang digunakan adalah instrumen model kepemimpinan yang pernah digunakan sebelumnya. Model kepemimpinan yang berhubungan dengan kinerja adalah servant, visioner, dan transaksional. Model kepemimpinan yang paling dominan berhubungan dengan kinerja adalah servant (p= 0,0001; α= 0,05; CI: 2,733–11,853; Odd Ratio: 5,691). Kepala ruangan yang dipersepsikan oleh perawat pelaksana menggunakan model kepemimpinan servant berpeluang meningkatkan kinerja perawat pelaksana sebesar 5 kali lebih tinggi dibandingkan dengan yang tidak dipersepsikan menggunakan model kepemimpinan servant. Hasil penelitian ini merekomendasikan kepada pimpinan Rumah sakit khususnya untuk kepala ruangan dapat menggunakan model kepemimpinan servant dalam peran dan fungsinya untuk meningkatkan kinerja perawat pelaksana. Kata kunci: Kinerja perawat pelaksana, Model kepemimpinan servant.  Abstract Head Nurse Leadership Model Can Improve The Performance of Nurses in Providing Nursing Care. The purpose of this study was to identify the correlation between the head nurse leadership model and the nurses’ performance. This study applied a cross-sectional method and involved 141 nurses at a Hospital. This study used the instruments was developed in the other studies. The results showed that the leadership model related to the performance was a servant, visionary, and transactional. The most dominant leadership model related to the performance was servant (p= 0.0001; α= 0.05, CI: 2.733 to 11.853; odds ratio: 5.691). Head nurses that were perceived by nurses as using the servant leadership model had an opportunity to improve the nurses’ performance five times higher than those who were not perceived as using the servant leadership model. It is recommended that the head of Hospitals, especially the head nurses, to apply the servant leadership model in their roles and functions to improve the nurses’ performance.  Keywords: Nurses’ performance, Servant Leadership model
THE EFFECT OF SOCIAL MEDIA E-MARKETING TOWARDS CONSUMERS SHOPPING BEHAVIOR
Authors: Onarelly Arius Krypton , Tantuah Naldo , Satria Hardika Widi
Published: December 2018

Abstract: As the numbers of Internet users increase, the trend of online transactions also increase. E- marketing is one of a selling strategy using social media such as Facebook, Instagram, Twitter, Whatsapp, BBM and LinkedIn. The purpose of this study was to analyze the simultaneous and partial effect of E-Marketing to the shopping behavior of respondents. Data were obtained from questionnaires given to 100 student respondents of Indonesian vocational education. The analytical method used in this research is the t test and F test using SPSS 17. Based on results of the study it is found that three factors affected shopping behavior of these respondents through their online transaction via social media, namely accessibility, currency and interactivity. All e-marketing variables influenced the behavior of consumers. However, there are also some e-marketing variables affecting shopping behavior of respondents in different factors. From the cultural factor, shopping behavior is influenced by the accessibility and currency variables, while an effected variable linked to personal factors is accessibility alone. For psychological factors, the only effecting variable is interactivity. But overall e-marketing variables affected the shopping behavior of respondents.Keywords: Consumer behavior, E-marketing, Online shop, Social media, Shopping, Qualification
PENGARUH PERLUASAN MEREK TERHADAP CITRA MEREK (STUDI PADA FRESTEA-FRESTEA GREEN)
Authors: Santoso Radityo Kusumo , Grataridarga Niko
Published: December 2018

Dengan berkembangnya trend masyarakat mengenai kebutuhan akan minimum yang menyehatkan, mendorong produsen minuman menjawab trend tersebut dengan mengeluarkan produk baru, dimana didalam peluncuran produk baru tersebut selain mengenalkan produk baru produsen juga sekaligus ingin menciptakan ekuitas merek yang kuat. Oleh sebab itu, produsen menggunakan perluasan merek. Tujuan dari penelitian ini untuk menganalisis pengaruh perluasan merek terhadap citra merek. Penelitian ini merupakan penelitian dengan pendekatan kuantitatif dengan analisis eksplanasi dan regresi linier berganda, instrumen yang peneliti gunakan adalah kuesioner. Berdasarkan hasil penelitian menyatakan bahwa satu dari lima dimensi yaitu : perceived quality, secara signifikan mempengaruhi citra merek, sedangkan keempat dimensi lainnya tidak mempengaruhi secara signifikan. Hasil analisa menunjukkan bahwa perluasan merek mempengaruhi citra merek sebesar 59.7%, sedangkan sisanya sebesar 40.3% dipengaruhi oleh variabel lain. Kata kunci : Perluasan merek, Citra merek, regresi berganda
Implementasi Sosialisasi Peraturan Pemerintah No. 23 Tahun 2018 Bagi Pelaku Usaha Mikro, Kecil Dan Menengah (UMKM)
Authors: - Hendri
Published: December 2018

Usaha Mikro, Kecil dan Menengah (UMKM) yang berkembang begitu pesat dari tahun ke tahun telah menimbulkan kewajiban perpajakan bagi pelaku usaha tersebut. Untuk membantu Wajib Pajak UMKM pemerintah pada tahun 2013 telah mengeluarkan Peraturan Pemerintah (PP) nomor 46. Setelah beberapa tahun dilaksanakan kini pemerintah telah mengeluarkan penyempurnaan dari peraturan tersebut yakni dengan mengeluarkan PP No. 23 Tahun 2018. Peraturan ini dikeluarkan untuk memberikan keringanan tarif bagi para pelaku usaha UMKM. Namun  PP yang disahkan pada pertengahan tahun 2018 ini dirasakan masih kurang sosialisasi kepada para wajib pajak. Penelitian ini berfokus pada pemahaman para wajib pajak terkait implementasi aturan tersebut.Kata kunci: Pajak, UMKM, Peraturan Pemerintah, Implementasi dan Sosialisasi
Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis
Authors: Vervoort Stephin J , de Jong Olivier G , Roukens M Guy , Frederiks Cynthia L , Vermeulen Jeroen F , Lourenço Ana Rita , Bella Laura , Vidakovic Ana Tufegdzic , Sandoval José L , Moelans Cathy , van Amersfoort Miranda , Dallman Margaret J , Bruna Alejandra , Caldas Carlos , Nieuwenhuis Edward , van der Wall Elsken , Derksen Patrick , van Diest Paul , Verhaar Marianne C , Lam Eric W-F , Mokry Michal , Coffer Paul J
Published: December 2018

The expression of the transcription factor SOX4 is increased in many human cancers, however, the pro-oncogenic capacity of SOX4 can vary greatly depending on the type of tumor. Both the contextual nature and the mechanisms underlying the pro-oncogenic SOX4 response remain unexplored. Here, we demonstrate that in mammary tumorigenesis, the SOX4 transcriptional network is dictated by the epigenome and is enriched for pro-angiogenic processes. We show that SOX4 directly regulates endothelin-1 (ET-1) expression and can thereby promote tumor-induced angiogenesis both in vitro and in vivo. Furthermore, in breast tumors, SOX4 expression correlates with blood vessel density and size, and predicts poor-prognosis in patients with breast cancer. Our data provide novel mechanistic insights into context-dependent SOX4 target gene selection, and uncover a novel pro-oncogenic role for this transcription factor in promoting tumor-induced angiogenesis. These findings establish a key role for SOX4 in promoting metastasis through exploiting diverse pro-tumorigenic pathways.
Membrane fluidity is regulated by the C. elegans transmembrane protein FLD-1 and its human homologs TLCD1/2
Authors: Ruiz Mario , Bodhicharla Rakesh , Svensk Emma , Devkota Ranjan , Busayavalasa Kiran , Palmgren Henrik , Ståhlman Marcus , Boren Jan , Pilon Marc
Published: December 2018

Dietary fatty acids are the main building blocks for cell membranes in animals, and mechanisms must therefore exist that compensate for dietary variations. We isolated C. elegans mutants that improved tolerance to dietary saturated fat in a sensitized genetic background, including eight alleles of the novel gene fld-1 that encodes a homolog of the human TLCD1 and TLCD2 transmembrane proteins. FLD-1 is localized on plasma membranes and acts by limiting the levels of highly membrane-fluidizing long-chain polyunsaturated fatty acid-containing phospholipids. Human TLCD1/2 also regulate membrane fluidity by limiting the levels of polyunsaturated fatty acid-containing membrane phospholipids. FLD-1 and TLCD1/2 do not regulate the synthesis of long-chain polyunsaturated fatty acids but rather limit their incorporation into phospholipids. We conclude that inhibition of FLD-1 or TLCD1/2 prevents lipotoxicity by allowing increased levels of membrane phospholipids that contain fluidizing long-chain polyunsaturated fatty acids.

Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).
Attention periodically samples competing stimuli during binocular rivalry
Authors: Davidson Matthew J , Alais David , van Boxtel Jeroen JA , Tsuchiya Naotsugu
Published: December 2018

The attentional sampling hypothesis suggests that attention rhythmically enhances sensory processing when attending to a single (~8 Hz), or multiple (~4 Hz) objects. Here, we investigated whether attention samples sensory representations that are not part of the conscious percept during binocular rivalry. When crossmodally cued toward a conscious image, subsequent changes in consciousness occurred at ~8 Hz, consistent with the rates of undivided attentional sampling. However, when attention was cued toward the suppressed image, changes in consciousness slowed to ~3.5 Hz, indicating the division of attention away from the conscious visual image. In the electroencephalogram, we found that at attentional sampling frequencies, the strength of inter-trial phase-coherence over fronto-temporal and parieto-occipital regions correlated with changes in perception. When cues were not task-relevant, these effects disappeared, confirming that perceptual changes were dependent upon the allocation of attention, and that attention can flexibly sample away from a conscious image in a task-dependent manner.
How does social enrichment produce health benefits?
Authors: Kikusui Takefumi
Published: December 2018

Oxytocin appears to link social interaction and cell aging in rats, especially in females.
Deriving ablative, privative, and reversative meanings in Catalan and Spanish
Authors: Gibert-Sotelo Elisabeth
Published: December 2018

The most productive way to encode ablative, privative, and reversative meanings in current Catalan and Spanish is by means of des- prefixation. This paper investigates how these related values are obtained both from a structural and from a conceptual perspective. To analyze the structural behaviour of these predicates, a new neo-constructionist model is adopted: Nanosyntax, according to which lexical items are syntactic constructs. As for the conceptual content associated to these verbs, it is accounted for by means of a non-canonical approach to the Generative Lexicon Theory developed by Pustejovsky (1995 ff.).The core proposal is that des- prefixed verbs with an ablative, a privative, or a reversative meaning share the same syntactic structure, and that the different interpretation of each semantic class emerges as a consequence of the interactions generated, at a conceptual level, between the Qualia Structure of the verbal root and that of the internal argument of the verb.
Urbanisation and wing asymmetry in the western honey bee (Apis mellifera, Linnaeus 1758) at multiple scales
Authors: Leonard Ryan J. , Wat Katie K.Y. , McArthur Clare , Hochuli Dieter F.
Published: December 2018

Changes in the mean and variance of phenotypic traits like wing and head morphology are frequently used as indicators of environmental stress experienced during development and may serve as a convenient index of urbanization exposure. To test this claim, we collected adult western honey bee (Apis mellifera Linnaeus 1758, Hymenoptera, Apidae) workers from colonies located across an urbanization gradient, and quantified associations between the symmetries of both wing size and wing shape, and several landscape traits associated with urbanization. Landscape traits were assessed at two spatial scales (three km and 500 m) and included vegetation and anthropogenic land cover, total road length, road proximity and, population and dwelling density. We then used geometric morphometric techniques to determine two wing asymmetry scores—centroid size, a measure of wing size asymmetry and Procrustes distance, a measure of wing shape asymmetry. We found colony dependent differences in both wing size and shape asymmetry. Additionally, we found a negative association between wing shape asymmetry and road proximity at the three km buffer, and associations between wing shape asymmetry and road proximity, anthropogenic land cover and vegetation cover at the 500 m buffer. Whilst we were unable to account for additional variables that may influence asymmetry including temperature, pesticide presence, and parasitism our results demonstrate the potential usefulness of wing shape asymmetry for assessing the impact of certain landscape traits associated with urbanization. Furthermore, they highlight important spatial scale considerations that warrant investigation in future phenotypic studies assessing urbanization impact.
NCR3 polymorphism, haematological parameters, and severe malaria in Senegalese patients
Authors: Thiam Alassane , Baaklini Sabrina , Mbengue Babacar , Nisar Samia , Diarra Maryam , Marquet Sandrine , Fall Mouhamadou Mansour , Sanka Michel , Thiam Fatou , Diallo Rokhaya Ndiaye , Torres Magali , Dieye Alioune , Rihet Pascal
Published: December 2018

Background

Host factors, including host genetic variation, have been shown to influence the outcome of Plasmodium falciparum infection. Genome-wide linkage studies have mapped mild malaria resistance genes on chromosome 6p21, whereas NCR3-412 polymorphism (rs2736191) lying within this region was found to be associated with mild malaria.

Methods

Blood samples were taken from 188 Plasmodium falciparum malaria patients (76 mild malaria patients, 85 cerebral malaria patients, and 27 severe non-cerebral malaria patients). NCR3-412 (rs2736191) was analysed by sequencing, and haematological parameters were measured. Finally, their association with clinical phenotypes was assessed.

Results

We evidenced an association of thrombocytopenia with both cerebral malaria and severe non-cerebral malaria, and of an association of high leukocyte count with cerebral malaria. Additionally, we found no association of NCR3-412 with either cerebral malaria, severe non-cerebral malaria, or severe malaria after grouping cerebral malaria and severe non-cerebral malaria patients.

Conclusions

Our results suggest that NCR3 genetic variation has no effect, or only a small effect on the occurrence of severe malaria, although it has been strongly associated with mild malaria. We discuss the biological meaning of these results. Besides, we confirmed the association of thrombocytopenia and high leukocyte count with severe malaria phenotypes.
CARE Dose 4D combined with sinogram‐affirmed iterative reconstruction improved the image quality and reduced the radiation dose in low dose CT of the small intestine
Authors: Wang Lin , Gong Shenchu , Yang Jushun , Zhou Jie , Xiao Jing , Gu Jin‐hua , Yang Hong , Zhu Jianfeng , He Bosheng
Published: December 2018

Objective

Multislice computed tomography (MSCT) has been used for diagnosis of small intestinal diseases. However, the radiation dose is a big problem. This study was to investigate whether CARE Dose 4D combined with sinogram‐affirmed iterative reconstruction (SAFIRE) can provide better image quality at a lower dose for imaging small intestinal diseases compared to MSCT.

Methods

The noise reduction ability of SAFIRE was assessed by scanning the plain water mold using SOMATOM Definition Flash double‐source spiral CT. CT images at each stage of radiography for 239 patients were obtained. The patients were divided into groups A and B were based on different tube voltage and current or the image recombination methods. The images were restructured using with filtered back projection (FBP) and SAFIRE (S1–S5). The contrast noise ratio (CNR), CT Dose index (CTDI), subjective scoring, and objective scoring were compared to obtain the best image and reformation parameters at different stages of CT.

Results

Twenty‐six restructuring patterns of tube voltage and current were obtained by FBP and SAFIRE. The average radiation dose using CARE Dose 4D combined with SAFIRE (S4–S5) reduced approximately 74.85% compared to conditions where the tube voltage of 100 kV and tube current of 131 mAs for patients with MSCT small intestinal CT enterography at plain CT scan, arterial stage, small intestine, and portal venous phase. The objective and subjective scoring were all significantly different among groups A and B at each stage.

Conclusions

Combination of CARE Dose 4D and SAFIRE is shown to decrease the radiation dose while maintaining image quality.
Elevate360, new program in NYC, focused on family, CRAFT
Authors: Knopf Alison
Published: December 2018

Sarah H. Church, Ph.D., executive director of the Division of Substance Abuse at Montefiore Medical Center and an assistant professor in the Department of Psychiatry and Behavioral Sciences at the Albert Einstein College of Medicine, is starting a new venture: a treatment program based on harm‐reduction techniques embodied in the work of Robert Meyers, who developed Community Reinforcement and Family Training (CRAFT). Called Elevate360, the program opened this fall and is aimed at helping people in New York City who want outpatient treatment for addiction (see ADAW, Oct. 22).
High Performance Antistatic HDPE Composites with Bridging Effect of Hybrid Carbon Black and Multi‐Walled Carbon Nanotubes Fillers
Authors: Wang Quan , Cheng Lihong , Wang Jikui , Qian Ziming , Wei Ting , Guo Weihong
Published: December 2018

Carbon black (CB) is an electrical and reinforced material, which is used for many industrial applications; however, the serious aggregation of CB requires the addition of large amounts for the composites to meet the requirements of the antistatic properties. Multi‐walled carbon nanotubes (MWCNTs) are linear high electrical materials, and they are also easy to wrap with each other. Therefore, considering different shapes of CB and MWCNTs, the MWCNTs are selected as the bridge to connect CB to decrease the added amount of CB in the composites, and the results show that the bridge effect is efficient enough. The process uses a one‐step melt blending method, which is very easy and environmentally friendly. When 1 wt% CB and 0.5 wt% MWCNTs are added into the composites, the surface, and volume resistivity of the composites are much lower than those of the composites by adding 3 wt% CB, due to the bridge effect, fulfilling the antistatic properties of the composites.
Plasticized Hybrid Network Solid Polymer Electrolytes for Lithium‐Metal Batteries
Authors: Huang Ziyin , Pan Qiwei , Smith Derrick M. , Li Christopher Y.
Published: December 2018

Incorporating solid polymer electrolyte (SPE) into lithium metal batteries has the benefit of employing the electrolyte as the electrode separator while inhibiting the growth of lithium dendrites. The two main models on lithium dendrite growth show that either ionic conductivity or mechanical property affect lithium dendrite nucleation and growth rate. In this work, with a well‐controlled hybrid network SPE as the model system, the modulus and conductivity of the hybrid SPEs are systematically tuned by plasticizing the network with low molecular with diluents. This systematic property control allows for establishing the correlation between mechanical/electrochemical properties of the SPEs with their propensity of lithium dendrite resistance using galvanostatic polarization and cycling experiments. It is further demonstrated that lithium metal batteries can be operated at 30 °C for the plasticized SPEs due to the dramatically improved conductivity.
Self‐Assembled Ag–TiN Hybrid Plasmonic Metamaterial: Tailorable Tilted Nanopillar and Optical Properties
Authors: Wang Xuejing , Jian Jie , Zhou Zhiguang , Fan Cuncai , Dai Yaomin , Li Leigang , Huang Jijie , Sun Jianing , Donohue Andrea , Bermel Peter , Zhang Xinghang , Chen Hou‐Tong , Wang Haiyan
Published: December 2018

Key challenges limiting the adoption of metallic plasmonic nanostructures for practical devices include structural stability and the ease of large‐scale fabrication. Overcoming these issues may require novel metamaterial fabrication with potentials for improved durability under extreme conditions. Here, a self‐assembled growth of a hybrid plasmonic metamaterial in thin‐film form is reported, with epitaxial Ag nanopillars embedded in TiN, a mechanically strong and chemically inert matrix. One of the key achievements lies in the successful control of the tilt angle of the Ag nanopillars (from 0° to 50°), which is attributed to the interplay between the growth kinetics and thermodynamics during deposition. Such an anisotropic nature offered by the tilted Ag nanopillars in TiN matrix is crucial for achieving broadband, asymmetric optical selectivity. Optical spectra coupled with numerical simulations demonstrate strong plasmonic resonance, as well as angular selectivity in a broad UV–vis to near‐infrared regime. The nanostructured metamaterials in this work, which consist of highly conductive metallic nanopillars in a durable nitride matrix, have the potential to serve as a novel hybrid material platform for highly tailorable nanoscale metamaterial designs, suitable for high temperature optical applications.
Direct β‐Selective Styrylation of BODIPY Dyes via Palladium(II)‐Catalyzed C−H Functionalization
Authors: Wang Jun , Wu Qinghua , Gong Qingbao , Cheng Kai , Liu Qingyun , Yu Changjiang , Hao Erhong , Jiao Lijuan
Published: December 2018

A general and efficient method for direct β‐selective styrylation of BODIPYs has been developed based on Palladium(II)‐catalyzed oxidative C−H functionalization. The high β‐regioselectivity was confirmed by X‐ray analysis. The resulting dyes showed bathochromically shifted absorption and emission compared to that of the starting BODIPYs. This strategy, as a late‐stage approach to rapidly assemble a diversity‐oriented BODIPY library, provides a straightforward way to extend the conjugation of the BODIPY system at 2,6‐positions.

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A Fully Transparent, Flexible, Sensitive, and Visible‐Blind Ultraviolet Sensor Based on Carbon Nanotube–Graphene Hybrid
Authors: Pyo Soonjae , Choi Jungwook , Kim Jongbaeg
Published: December 2018

Transparent and flexible UV sensors have attracted considerable attention for use in portable/wearable optoelectronic systems. Although UV sensors based on photoactive nanomaterials have been reported for such applications, achieving full transparency and flexibility remains a challenge because they still rely on opaque or brittle electrodes. Here, a fully transparent, flexible, and highly sensitive UV sensor based on 1D carbon nanotubes (CNTs)–2D graphene hybrid is demonstrated. Under UV illumination, oxygen molecules on the CNT surfaces are desorbed by photoinduced plasmon energy, leading to a significant decrease in hole concentration, and correspondingly an increase in the electrical resistance of CNT. The combination of CNT and graphene minimizes the effect of contact resistance and facilitates effective charge transfer between them without potential barrier, resulting in a high photoresponse, which is 30 times as high as that of Au‐electrode‐based CNT sensor. Simultaneously, CNT–graphene UV sensor shows remarkable transparency (over 80% at 550 nm) and outstanding mechanical flexibility without any significant change in electrical resistance for 500 cycles at a bending radius of 5.5 mm. The integration of CNT–graphene hybrid onto flexible substrates through scalable microfabrication is expected to provide exciting opportunities for the development of high performance, optically and mechanically invisible optoelectronic devices.
Evidence for increased genetic risk load for major depression in patients assigned to electroconvulsive therapy
Authors: Foo Jerome C. , Streit Fabian , Frank Josef , Witt Stephanie H. , Treutlein Jens ,   Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Baune Bernhard T. , Moebus Susanne , Jöckel Karl‐Heinz , Forstner Andreas J. , Nöthen Markus M. , Rietschel Marcella , Sartorius Alexander , Kranaster Laura
Published: December 2018

Electroconvulsive therapy (ECT) is the treatment of choice for severe and treatment‐resistant depression; disorder severity and unfavorable treatment outcomes are shown to be influenced by an increased genetic burden for major depression (MD). Here, we tested whether ECT assignment and response/nonresponse are associated with an increased genetic burden for major depression (MD) using polygenic risk score (PRS), which summarize the contribution of disease‐related common risk variants. Fifty‐one psychiatric inpatients suffering from a major depressive episode underwent ECT. MD‐PRS were calculated for these inpatients and a separate population‐based sample (n = 3,547 healthy; n = 426 self‐reported depression) based on summary statistics from the Psychiatric Genomics Consortium MDD‐working group (Cases: n = 59,851; Controls: n = 113,154). MD‐PRS explained a significant proportion of disease status between ECT patients and healthy controls (p = .022, R2 = 1.173%); patients showed higher MD‐PRS. MD‐PRS in population‐based depression self‐reporters were intermediate between ECT patients and controls (n.s.). Significant associations between MD‐PRS and ECT response (50% reduction in Hamilton depression rating scale scores) were not observed. Our findings indicate that ECT cohorts show an increased genetic burden for MD and are consistent with the hypothesis that treatment‐resistant MD patients represent a subgroup with an increased genetic risk for MD. Larger samples are needed to better substantiate these findings.
Rhodium‐Catalyzed Annulation of ortho‐Alkenyl Anilides with Alkynes: Formation of Unexpected Naphthalene Adducts
Authors: Seoane Andrés , Comanescu Cezar , Casanova Noelia , García‐Fandiño Rebeca , Diz Xabier , Mascareñas José L. , Gulías Moisés
Published: December 2018

o‐Alkenyl N‐triflylanilides underwent rhodium(III)‐catalyzed oxidative annulations with alkynes to produce different types of naphthylamides in a process which involves the cleavage of two C−H bonds. Remarkably, besides formal dehydrogenative (4C+2C) cycloadducts, the reaction also produces variable amounts of isomeric naphthylamides, whose formation requires a formal migration of the alkenyl moiety from the ortho to the meta position of the anilide. The annulation reaction can be efficiently carried out in the absence of external oxidants, such as Cu(OAc)2.
Manipulation of Spiroindolenine Intermediates for Enantioselective Synthesis of 3‐(Indol‐3‐yl)‐Pyrrolidines
Authors: Xia Zi‐Lei , Zheng Chao , Liang Xiao‐Wei , Cai Yue , You Shu‐Li
Published: December 2018

By manipulating the reactivity of spiroindolenine species, a sequential Michael/retro‐Mannich/Mannich reaction of ω‐indol‐3‐yl α,β‐unsaturated ketones was developed. In the presence of 10 mol % of a chiral phosphoric acid as the catalyst, a series of 3‐(indol‐3‐yl)‐pyrrolidines were synthesized in high yields (up to 91 %) with excellent stereoselectivities (up to 92 % ee, >19:1 d.r.). The products obtained here undergo diverse functional‐group transformations. The mechanistic proposal of this reaction is supported by DFT calculations.
Structure, atomic Hirshfeld surface, spectroscopic studies and magnetic and dielectric properties of new mixed solid solution (NH4)2Mn0.17Cu0.83Cl4⋅2H2O
Authors: Messoudi Nouha , Valente Manuel Almeida , Dhahri Essebti , Loukil Mohamed
Published: December 2018

The tetrachlorocupratmanganate dehydrate (NH4)2Mn0.17Cu0.83Cl4⋅2H2O has been prepared and characterized using various physicochemical techniques including Fourier transform infrared and Raman spectroscopies, differential scanning calorimetry and dielectric and magnetic measurements. A preliminary single‐crystal X‐ray diffraction structural analysis reveals that the title compound belongs to the tetragonal system with P4(2)/mnm space group. The unit cell dimensions are: a = b = 7.5817(2), c = 7.9312(2) Å, with Z = 2. Its crystal structure was determined and refined down to R = 2%. The structure of this compound consists of discrete [Cu/MnCl4⋅2H2O]2− octahedra interleaved with alkali cations. The cohesion and stabilization of the structure are provided by hydrogen bond interactions (N─H…Cl and O─H…Cl) between [NH4]+ cation and [Cu/MnCl4⋅2H2O]2− anion. Hirshfeld surface analysis has been performed to explore the behaviour of these weak interactions. Dielectric measurements confirm the transition temperatures determined using differential scanning calorimetry. The temperature dependence of the magnetic susceptibility was measured in the temperature range 10–300 K at various magnetic field intensities. Magnetic measurements reveal the occurrence of weak ferromagnetic behaviour at low temperature (Tc = 12 K). The ferromagnetic ordering is further confirmed by the presence of hysteresis loops.
Effect of electron‐beam irradiation on the thermal vulcanization of a natural rubber compound
Authors: Espósito Leandro H. , Marzocca Angel J.
Published: December 2018

The influence of electron‐beam irradiation on the thermal vulcanization curing kinetics of a natural rubber compound was investigated by means of rheometric tests [moving die rheometry (MDR)] and differential scanning calorimetry (DSC). Differences in the storage moduli of compounds with different radiation doses were observed and assigned to a plasticizer effect by the zinc stearate mainly formed in the mixing stages; this compound migrated to the interphase region. This fact was confirmed by Fourier transform infrared spectroscopy. From the measurements performed by MDR and DSC testing, the induction time (to) was analyzed in the frame of the Claxton–Liska model, whereas the kinetic behavior of the nonirradiated and pre‐irradiated compounds were satisfactorily fitted with the Isayev–Deng and Kamal–Ryan models. Additionally, both curing characterization techniques corroborated the fact that the pre‐irradiated rubber compound showed an earlier t
o and a lower activation energy in comparison with the nonirradiated compound. These facts were attributed to the effect of irradiation on the free sulfur content present in the rubber compound, which promoted more activated precursor species to crosslink with rubber. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47216.