bluuebunny/crossref_metadata_2025 huggingface dataset:
Patterns of information literacy and their predictors among emergency department nurses: a latent profile analysis based on the Person-Context interaction theory
Authors: Wu Chao , He Chunyan , Yan Jiaran , Du Juan , He Shizhe , Ji Zhaohua , Wang Yifei , Lang Hong-juan
Published: September 2023

Aim To clarify the subtypes of information literacy among nurses in the emergency department and explore the factors affecting profile membership. Methods A cross-sectional study was conducted among a convenience sample of 2490 nurses in the emergency department from April to June 2023. The clinical nurses completed the online self-report questionnaires including the general demographic questionnaire, information literacy scale, self-efficacy scale and social support scale. Data analyses consisted of latent profile analysis, variance analysis, Chi-square test and multivariate logistic regression. Results Four latent profiles were identified: ‘Low information literacy (Class 1)’, ‘Moderate information knowledge (Class 2)’, ‘High information knowledge and support (Class 3)’ and ‘High information literacy (Class 4)’, accounting for 20.14%, 42.11%, 23.36% and 14.39%, respectively. Different information literacy patterns have different characteristics. Age, years of work, place of residence, hospital grade, title, professional knowledge, using databases, reading medical literature, participating in information literacy training, self-efficacy, and social support significantly predicted information literacy profile membership. Conclusions Information literacy has different classification features among emergency department nurses, and over half of the nurses surveyed were at the lower or middle level. Identifying sociodemographic and internal-external predictors of profile membership may be useful for preparing interventions that will be better suited to emergency department nurses’ needs. Nursing managers should actively pay attention to nurses with low information literacy and help them improve their information literacy level. Relevance to clinical practice Insights from the current study of the latent profile analysis are beneficial to hospital managers in understanding the different types of emergency department nurses' information literacy and provide a reference for them to improve nurses’ information literacy levels.
Ultrasound-guided disc pain induction test for diagnosis of discogenic lumbar pain: A cross-sectional study
Authors: Masuda Keisuke , Shigematsu Hideki , Maeda Manabu , Tanaka Masato , Okuda Akinori , Kawasaki Sachiko , Suga Yuma , Yamamoto Yusuke , Tanaka Yasuhito
Published: September 2023

Background: Several methods can be used to diagnose discogenic pain, but only discoblock can diagnose discogenic pain definitively. This study aimed to examine the usefulness of an ultrasound-guided disc pain induction test for a simple and accurate diagnosis of the culprit lesion.
Methods: We included 41 patients with lumbar pain in whom pain was induced by an ultrasound-guided disc pain induction test. All patients had confirmed pain at L1/2 to L5/S1 based on an ultrasound-guided disc pain induction test and underwent X-ray photography and magnetic resonance imaging. Seventeen patients who required injection due to severe pain underwent discoblock procedures for discs with the most intense pain, and visual analog scale (VAS) scores were obtained before and after the procedure for these patients. We analyzed the association between painful discs and radiological findings.
Results: Pain induction was noted in a total of 65 discs, and the pain was induced in 23 patients in only one disc. All patients had disc degeneration of Pfirrmann classification grade 1 or higher, with more significant disc degeneration in painful discs than in painless discs. There was no significant relationship between the presence or absence of pain and Modic type.
The average VAS measurements improved significantly from 9.5 (pre-procedure) to 2.5 (post-procedure). These results suggest that the most painful discs were the causes of discogenic lumbar pain.
Conclusions: Our ultrasound-guided disc pain induction test may help diagnose disc degeneration and identify culprit lesions, even when multiple discs exhibit findings of degeneration.
Molecular epidemiology of carbapenem and colistin resistant Acinetobacter baumanii
Authors: Rout Bidyut Prava , Dash Sumesh Kumar , Otta Sarita , Behera Birasen , Praharaj Ira , Sahu Kundan Kumar
Published: September 2023

Introduction- Acinetobacter baumanii (AB) is a bacterium of concern in the hospital set up due to its ability to thrive in unfavorable conditions as well as rapid emergence of antibiotic resistance. Carbapenem resistance in this organism is disheartening which is further clouded by emergence of colistin resistance.
Aim- The present prospective study aims to note the epidemiology, molecular profile, and clinical outcome of patients with colistin resistance ABinfections in a multispecialty tertiary care set up in Odisha in Eastern India.
Methods- All AB strains received from March 2021 to February 2022 as identified by Vitek2, Biomerieux and confirmed by oxa-51 genes were included. Carbapenem and colistin resistance was identified as per CLSI guidelines. Known mutations for blaOXA-23-like, blaIMP, blaVIM, blaKP, lpxA, lpxC, pmrA, pmrB and plasmid mediated mcr (mcr1-5) were screened by conventional PCR techniques. The clinical outcome was noted retrospectively from case sheets. Data was entered in excel and tabulated using SPSS software.
Results- In the study period, 350 AB were obtained of which 317(90.5%) were carbapenem resistant (CRAB). Among the CRAB isolates 19 (5.9%) were colistin resistant (CR). Most useful antibiotics in the study were tigecycline (65.4% in CI; 31.6% in CR) and minocycline (44.3% in CI; 36.8% in CR). There was significant difference in mortality among ABCoI and ABCoR infections.bla OXA was the predominant cerbapenem resistance genotype while pmrA was the predominant colistin resistant genotype. There were no plasmid mediated mcr genes detected in the present study.
Screening of Drinking Water for Contamination Diarrhoeal Disease Prevalence Among Children Below the Age of Five in Kaduna Metropolis, Kaduna State, Nigeria
Authors: MALGWI DORIS , MALGWI CHARITY , ADOGU PROSPER , NWOKO DEBORAH
Published: September 2023

Access to water supply and sanitation facilities has considerable health and economic benefits for households and individuals. However, lack of access to safe drinking water and inadequate disposal of human excreta is associated with various diseases, including diarrhoea; diarrhoea is the second leading cause of under-five mortality in developing countries and Nigeria in particular. Microbiological water quality is usually assessed by the identification of Escherichia coli (E. coli), a fecal indicator. The hydrogen sulfide (H2S) test is an inexpensive, easy-to-use, and portable alternative field-based water quality test. This study aims to screen drinking water for contamination and prevalence of diarrhoeal diseases among children below five years of age in kaduna metropolis, kaduna state, Nigeria. A descriptive cross-sectional study involving 180 participants was carried out using a Modified WHO cluster sampling technique; semi-structured questionnaires were used to record bio-data and information in line with the objective of the study, drinking water from various sources were collected in orlab Hydrogen sulphide test vials, stored in an ambient temperature of about 25 ⁰ C – 35 0 C for 24hrs to confirm for blackening of water in the vial to identify faecal contamination. The prevalence of diarrhoea was 40.6% in all four local government areas that make up the Kaduna metropolis; 52.8% of the collected samples tested positive for bacteriological contamination using the test kit. 51.6% of the recorded positive test samples were obtained from employed mothers, 32.6% from unemployed mothers, and 15.8% from self-employed mothers. The mother's age was positively associated (p-value 0.00001 significant), the level of the mother's education (p value = 0.000915 significant), source of drinking water also showed a significant association (p-value 0.00001 significant). A high percentage of prevalence, knowledge, contaminated samples were observed. Also, all sociodemographic factors except religion and sex of child are positively associated with diarrhoea diseases.
Concession of airport clusters in Brazil: analysis of operators’ option to capture consumer surpluses
Authors: Oliveira Márcio Pacelli , Pompermayer Fabiano Mezadre , Sobrinho Edson Silveira
Published: September 2023

The presence of competing airports in the same concession cluster enables an environment conducing the capture of consumer surplus by the private operator, who seeks profit and can force demand to be diverted from the smaller, loss-making airport, to the larger and profitable airport. The Brazilian model airport concessions in clusters apparently does not consider the risks of loss of well-being for society and gains from producer surpluses for airports operating in regions with overlapping catchment areas, as in the case of airports in Curitiba, in Paraná, and Joinville, in Santa Catarina, 120 km apart. To assess the effects of the smaller airport’s closure this article carried out the socioeconomic analysis costs and benefits (CBA) and estimated the cost structure of the airports, their demand curves and the result of the joint operation, in addition to the variation in the loss of consumer surplus. For the consumer, the closure of the smaller airport is not interesting given the magnitude of the loss of surplus verified. From a regulatory point of view, preventing or remedying opportunistic actions by the concessionaire is a problem, given the asymmetry of information existing between the regulator and the regulated one.
Integrating transcriptomics, glycomics and glycoproteomics to characterize hepatitis B virus-associated hepatocellular carcinoma
Authors: Li Zhuo , Zhang Na , Dong Zewen , Wang Xin , Zhou Jian , Gao Juan , Yang Yunyun , Li Jing , Guan Feng , Tan Zengqi
Published: September 2023

Background Hepatocellular carcinoma (HCC) ranks as the third most common cause of cancer related death globally, representing a substantial challenge to global healthcare systems. In China, the primary risk factor for HCC is the hepatitis B virus (HBV). Aberrant serum glycoconjugate levels have long been linked to the progression of HBV-associated HCC (HBV-HCC). Nevertheless, few study systematically explored the dysregulation of glycoconjugates in the progression of HBV-associated HCC and their potency as the diagnostic and prognostic biomarker.Methods An integrated strategy that combined transcriptomics, glycomics, and glycoproteomics was employed to comprehensively investigate the dynamic alterations in glyco-genes, N-glycans, and glycoproteins in the initiation and development of HBV- HCC.Results Bioinformatic analysis of Gene Expression Omnibus (GEO) datasets uncovered dysregulation of fucosyltransferases (FUTs) in liver tissues from HCC patients compared to adjacent tissues. Glycomic analysis indicated an elevated level of fucosylated N-glycans, especially a progressive increase in fucosylation levels on IGHA1 and IGHG2 determined by glycoproteomic analysis.Conclusions The findings indicate that the abnormal fucosylation plays a pivotal role in the progression of HBV-HCC. Systematic and integrative multi-omic analysis is anticipated to facilitate the discovery of aberrant glycoconjugates in tumor progression.
Tuftelin1 Drives Experimental Pulmonary Fibrosis Progression by Facilitating Stress Fiber Assembly
Authors: Niu Caoyuan , Xu Kai , Hu Yanan , Jia Yanling , Pan Xiaoyue , Wan Ruyan , Lian Hui , Wang Qiwen , Wang Lan , Yang Juntang , Li Yajun , Rosas Ivan , Yu Guoying
Published: September 2023

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease (ILD) with unknown etiology, characterized by sustained damage repair of epithelial cells and abnormal activation of fibroblasts. However, the underlying mechanism of the disease remains elusive. This study was designed to evaluate the role of Tuftelin1 (TUFT1) in IPF and elucidate its molecular mechanism. We investigated the level of TUFT1 in the IPF and bleomycin-induced mouse models and explored the influence of TUFT1 deficiency on pulmonary fibrosis. Additionally, we explored the effect of TUFT1 on cytoskeleton and illustrated the relationship between stress fiber and pulmonary fibrosis. Our results demonstrated a significant upregulation of TUFT1 in IPF and the bleomycin-induced fibrosis model. Disruption of TUFT1 exerted inhibitory effects on pulmonary fibrosis in both in vivo and in vitro settings. Moreover, TUFT1 facilitated the assembly of microfilaments in A549 and MRC-5 cells, with a pronounced association between TUFT1 and N-WASP observed during microfilament formation. Meanwhile TUFT1 can promote the phosphorylation of tyrosine residue 256 (Y256) of the Neuronal Wiskott-Aldrich syndrome protein (pY256N-WASP). Furthermore, TUFT1 promoted TGF-β1 induced fibroblast activation by increasing nuclear translocation of pY256N-WASP in fibroblasts, while wiskostatin, a N-WASP inhibitor, suppressed these processes. Our findings suggested TUFT1 plays an important role in pulmonary fibrosis via its influence on stress fiber, and blockade of TUFT1 effectively reduces pro-fibrotic phenotypes. Pharmacological targeting of the TUFT1-N-WASP axis may represent a promising therapeutic approach for pulmonary fibrosis.
Analysis and validation of genes joint expression in Crohn's disease and cervical cancer based on GEO database.
Authors: ZHANG Le , Zou Jing , Wang Zhen , Shu Lindan , Jiang Bei , Liang Yi , ZHANG YuZhe
Published: September 2023

Background: In recent years, numerous studies have demonstrated an increased incidence of cervical cancer in women with Crohn's disease (CD). This paper aims to delve into the underlying mechanism of this association.
Methods: Gene expression profiles for Crohn's disease (GSE95095 and GSE186582) and cervical cancer (GSE63514 and GSE63678) were obtained from the GEO database. Heterozygotes (DEGs) were searched for in experimental and control groups for both diseases. Gene modules for Crohn's disease and cervical cancer were also analyzed using the WGCNA method. Machine learning (LASSO logistic regression algorithm & RF method) was applied to screen the characterized genes in the two diseases. And the transcription factors related to the characterized genes were predicted. Finally, it was validated by Western Blot (WB) and immunohistochemistry experiments.
Results: From the pool of differential genes in both disease groups, we identified a total of 60 co-expressed genes. Using the WGCNA method, we found 11 key modular genes that were common to both diseases. Machine learning screening allowed us to identify a shared biomarker for both diseases: CXCR4. Furthermore, we predicted MYC as its transcriptional regulator. Finally, to validate our findings, we conducted immunohistochemistry and protein immunoblotting experiments, which confirmed that CXCR4 exhibits a higher expression level in cervical cancer.
Conclusion: This study screened a gene co-expressed in Crohn's disease and cervical cancer based on machine learning: CXCR4, which is expected to be a potential biomarker for both diseases.
New Insights in the Distribution Profile of TRPC3 and TRPC5 in the Mouse and Human Kidney
Authors: Diebolt Coline M. , Schaudien Dirk , Junker Kerstin , Krasteva-Christ Gabriela , Tschernig Thomas , Englisch Colya N.
Published: September 2023

Several reports previously investigated Transient Receptor Potential Canonical subfamily channels 3 and 5 (TRPC3/TRPC5) in the kidney. However, most of the conclusions are based on animal samples or cell cultures leaving the door open for human tissue investigations. Moreover, results often disagreed among investigators. Histological description is lacking since most of these studies focused on functional aspects. Nevertheless, the same reports highlighted the potential differing key-roles of TRPC3 or TRPC5 in various renal disorders. Hence, our interest to investigate the localization of TRPC3 and TRPC5 in human kidneys. For this purpose, both healthy mouse and human kidney samples that were originated from tumor nephrectomies have been prepared for immunohistochemical staining using knockout-tested antibodies. Blocking peptides confirmed antibody specificity. A normalized weighted diaminobenzidine (DAB) area score between 0–3 comparable to a pixelwise H-score was established and employed for semiquantitative analysis. Altogether, our results suggest that glomeruli only express little TRPC3 and TRPC5 compared to several segments of the tubular system. Cortical and medullary proximal tubules are strongly stained. Intermediate tubules, however, are only weakly stained. The distal tubule was studied in three different localizations and depending on species and primary antibody, the staining was marked although slightly varying throughout the different localizations. Finally, the collecting duct was independently of primary antibody more stained in human compared to mouse tissue. We provide evidence that TRPC3 and TRPC5 are differently expressed in various localizations in both mouse and human samples. Especially, the TRPC5 distribution profile, we present here is completely new to our knowledge and raises questions, for instance its physiological relevance in the tubular system. We less verify results of previous studies than propose until now undescribed localizations of TRPC3 and TRPC5 in the mouse but especially and of greater interest in the human kidney. We thereby not only support the translational concept of TRPC channels as key players in physiology and pathophysiology of the human kidney but also present new potential targets to functional analysis.
Application of fractional exhaled nitric oxide and nasal nitric oxide in the evaluation of asthma control
Authors: Ma Yucong , Lin Wenying , Zheng Haoqi , Wang Yang , Cui Jingjing , Liu Li
Published: September 2023

Background
Asthma is the most common chronic respiratory disease in childhood. Persistent chronic airway inflammation is a pathological feature of asthma, so the control of airway inflammation is particularly important in asthma treatment. In recent years, fractional exhaled nitric oxide (FeNO) and fractional nasally exhaled nitric oxide (FnNO) has been used in the evaluation of airway inflammation.
Methods
This was a retrospective study. This study retrospectively analyzed the clinical data of 88 patients with asthma who received treatment and follow-up at The First Hospital of Jilin University from 2019 to 2022. The inclusion criteria were as follows: a. all patients met the criteria for diagnosis of bronchial asthma14; b. chronic persistent asthma was treated with standard protocols for more than 3 months; and c. the patient was able to cooperate with lung ventilation function tests and FeNO and FnNO examination.All subjects were divided into a control group, a partial control group and a poor control group according to Childhood Asthma Control Test (C-ACT) scores. FeNO, FnNO, and pulmonary function were compared among the three groups. We also analyzed whether FeNO and FnNO were correlated with various indices of pulmonary function in patients with asthma.
Results
The level of asthma control was not affected by rhinitis attacks. The FeNO and FnNO values of the poor control group were significantly higher than those of the partial control group and the control group. As asthma control improved, forced vital capacity (FVC) showed a statistically significant increase. The FEV1, maximal expiratory flow at 50% of the FVC (MEF50%) and maximal midexpiratory flow (MMEF) levels in the poor control group were significantly lower than those in the partial control group and the control group, and the PEF level of the poor control group was significantly lower than that of the control group. FeNO and FnNO had no significant correlation with pulmonary function parameters.
Conclusions
FeNO and FnNO should be used to assess the level of control in patients with asthma. There is no significant correlation among FeNO, FnNO and various parameters of pulmonary function.
Density Functional Theory calculations for Graphene Oxide, Zinc Oxide and Graphene oxide/zinc oxide composite structure
Authors: Hattab Ahmed Hamdi , Tapabashi Nashwan Omar , Khalil Najla Jalil
Published: September 2023

Graphene oxide is a complex substance that possesses significant implications in both theoretical and practical domains. In order to examine the potential of graphene oxide (GO) in reducing the high band gap of conducting materials, the electronic properties, including topography and band gap, the materials were assessed utilising density functional theory (DFT). calculations. The “B3LYP” technique was employed, along with the “6-31G” (d, p) and “LanL2DZ” basis sets. The quantum chemical parameters that have been calculated and found to be connected with reduced efficiency include total energy (E), highest occupied molecular orbital energy (EHOMO), lowest unoccupied molecular orbital energy (ELUMO), energy gap (EH−L), hardness (η), softness (S), and global electrophilicity index (ω). Applying the abbreviated Fukui function and abbreviated softness indicators facilitated the evaluation of potential regions for local reactivity. The results show that the total energy E is the highest at GO/ZnO composite which mean that it the most stable compound. While the EH−L for the composite was about 1.62 and this can prove the evidence that the composite is more relabel for the photo degradation than the ZnO in visible light.
Tuberculosis Reactivation Demonstrated By Choroiditis And Inflammatory Choroidal Neovascular Membrane In A Patient Treated With Immune Checkpoint Inhibitors For Malignant Mucosal Melanoma
Authors: Murphy Melissa Louise , Rogers Duncan
Published: September 2023

Purpose
To describe a complex case of ocular tuberculosis reactivation with anterior uveitis, choroiditis and inflammatory choroidal neovascular membrane (CNVM) following immune checkpoint inhibitor (ICPI) treatment of malignant mucosal melanoma.
Methods
A retrospective collection of medical history, clinical findings and multimodal imaging with literature review of the topic was conducted.
Results
A 52-year-old Romanian female developed reduced vision and photophobia after three cycles of ICPI therapy comprised of ipilimumab and nivolumab. Bilateral anterior uveitis, multiple left eye choroidal lesions and a CNVM were confirmed using slit-lamp examination with appropriate multimodal imaging. Retinal changes in the right eye as well as a history of previously treated posterior uveitis and high-risk ethnicity increased clinical suspicion for tuberculosis (TB) ocular reactivation. The diagnosis was confirmed by TB positivity on polymerase chain reaction (PCR) analysis of lung aspirate followed by significant clinical improvement on systemic anti-tubercular therapy (ATT), systemic steroids and anti-vascular endothelial growth factor (VEGF) therapy.
Conclusions
ICPIs can cause a myriad of ocular issues, both by primary immunomodulatory effects as well as secondary reactivation of latent disease.
Quality Indicators for Hospital Burn Care: A Scoping Review
Authors: Suzuki Denise R. Rabelo , Santana Levy Aniceto , Ávila Juliana Elvira H. Guerra , Amorim Fábio Ferreira , Modesto Guilherme Pacheco , Gotems Leila Bernarda Donato , Maldaner Vinicius
Published: September 2023

Background
The treatment of severe burns requires the management of a specialized multidisciplinary team and the coordination of several hospital services. Evaluating the quality of care provided to acute burn patients through quality indicators makes it possible to develop and implement measures aiming at better results. There is a lack of information on which indicators evaluate care in burn patients. The purpose of this scoping review was to identify a list of quality indicators used to evaluate the quality of hospital care provided to acute burn patients and indicate the gaps in current knowledge.
Method
A comprehensive scoping review (PRISMA-ScR) was conducted in four databases (PubMed, Cochrane Library, Embase, and Lilacs/VHL). Potentially relevant articles were evaluated for eligibility. General data and the identified quality indicators were collected for each included article. Each indicator was classified as a structure, process, or outcome indicator.
Results
A total of 1548 studies were identified, 82 were included, and their reference list was tracked, adding 19 more. Thus, data were collected from 101 studies. This review identified eight structure quality indicators, 72 process indicators, and 19 outcome indicators listed and subdivided according to their objectives.
Conclusion
This study obtained a list of quality indicators already used to monitor and evaluate the hospital care of acute burn patients, which may be useful for other research or be used in quality improvement programs.
Study Registration:
Protocol was registered on the Open Science Framework platform on June 27, 2022 (https://doi.org/10.17605/OSF.IO/NAW85).
Urinary Catheter-Directed Breast-Conserving Surgery for Incidentally Discovered Breast Cancer After Vacuum-assisted Breast Biopsy (VABB) Therapeutic Excision
Authors: Lu Yi , Qin Chuan , Zhou Chenghao , Cao Feilin , Li Zhanwen , Xie Xiaohong , Hu Guinv , Shen Jun , Zhou Yulu , Chen Cong , Li Zhaoqing , Sohail Ayesha , Singh Shreya , Zhou Jichun , Wang Linbo
Published: September 2023

Purpose
Vacuum-assisted breast biopsy (VABB) offers high accuracy in the diagnosis of breast tumors but makes the location of the original lesion difficult to identify when the subsequent breast-conserving surgery (BCS) is to be carried out. The aim of this study was to describe an effective technique to identify the exact location of the VABB cavity and to make breast-conserving resection more precise.
Methods
In this study, a balloon urinary catheter was inserted through the biopsy track; thus, the inflated balloon and catheter perfectly reconstructed the VABB cavity and biopsy track. Then breast-conserving resection with the guidance of the catheter was performed. Six patients were enrolled and assessed for their surgical findings, pathological results, surgical margins, and postoperative complications.
Results
Residual tumors were confirmed in 4 out of 6 patients after VABB. All the patients gained negative margins and underwent successful breast-conserving surgery. None of them required re-excisions. Satisfactory cosmetic results were observed after the catheter-directed BCS.
Conclusions
The results of this study show the effectiveness of urinary catheter-guided breast-conserving surgery after VABB. The procedure is simple and inexpensive. This new technique enabled precise breast-conserving resection of the targeted lesion and potentially improve successful rate of breast-conserving surgery.
A new definition of generalization of the factorial function with new results about the gamma of negative integers
Authors: Hussein Mohammed
Published: September 2023

The gamma function is a mathematical function that generalizes the concept of factorial to real and complex numbers. While the gamma function is a powerful tool in mathematics, it does have certain limitations and potential issues for example,
• Non-integer values: The gamma function is not defined for negative integers, this limitation can be problematic in certain contexts where negative integer values are involved.
• Pole at zero: The gamma function has a pole at zero, which means it is undefined at this point. This can pose challenges when working with functions or equations that involve the gamma function near or at zero.
• Computational complexity: Computing the gamma function numerically can be
computationally expensive and time-consuming, especially for large or complex arguments.
In this study, we have addressed the aforementioned issues by proposing a new definition for generalizing the factorial function, which serves as an alternative definition of the gamma function. This new definition is formulated based on the utilization of the differential operator.
The resulting definition stands out for its simplicity and effectiveness in computing real numbers, including non-positive integers. Moreover, our research has yielded fresh insights into the gamma function's behavior with respect to non-positive integers, potentially leading to a transformative approach in employing fractional differential and integral equations to describe a wide range of cosmic phenomena.
Two invertible networks for the matrix element method
Authors: Butter Anja , Heimel Theo , Martini Till , Peitzsch Sascha , Plehn Tilman
Published: September 2023

The matrix element method is widely considered the ultimate LHC inference tool for small event numbers. We show how a combination of two conditional generative neural networks encodes the QCD radiation and detector effects without any simplifying assumptions, while keeping the computation of likelihoods for individual events numerically efficient. We illustrate our approach for the CP-violating phase of the top Yukawa coupling in associated Higgs and single-top production. Currently, the limiting factor for the precision of our approach is jet combinatorics.
Production, quality of Paiaguas palisadegrass and cattle performance after sorghum intercropping in pasture recovery in an integrated crop-livestock system
Authors: Santos Charles Barbosa , Costa Kátia Aparecida de Pinho , Souza Wender Ferreira de , Silva Victor Costa e , Brandstetter Eduardo Valcácer , Oliveira Suelen Soares , Leão Karen Martins , Severiano Eduardo da Costa
Published: September 2023

To improve the conditions of livestock areas, integrated crop-livestock systems have proven to be a viable and sustainable alternative for pasture recovery. The objective of this study was to evaluate the production, quality of Paiaguas palisadegrass and cattle performance after intercropping with sorghum in the pasture recovery through an integrated crop-livestock system. The experiment was conducted in an experimental design in a randomized block design with four replicates in a 4 x 4 factorial scheme, with four forage systems: Paiaguas palisadegrass in monocropped, sorghum intercropped with Paiaguas palisadegrass in rows, sorghum intercropped with Paiaguas palisadegrass in interrow, and sorghum intercropped with oversown Paiaguas palisadegrass, evaluated in four seasons of the year (winter, spring, summer, and fall).The forage system did not influence the DM production, nutritive value, stocking rate and weight gain, being that all forms of sowing can be indicated due to the good development of Paiaguas palisadegrass after the sorghum harvest, showing several alternatives for implantation of the crops in intercropping. The summer and fall seasons provided higher forage availability and nutritive value, resulting in greater weight gain and better performance per animal per area. Paiaguas palisadegrass has good potential in pasture formation, recovery, and/or renewal, showing resistance to the dry period of the year (winter and fall).
Characteristics of two Panicum maximum grass cultivars fertilized with ash from wood grown in tropical soils
Authors: Silva Edna Maria Bonfim- , Alves Daniele Job , Mazero Horácio Manfrin , Oliveira Niclene Ponce Rodrigues de , Oliveira Jakeline Rosa de , Silva Tonny José Araújo da
Published: September 2023

It is estimated that the livestock sector accounts for about 40% of the value of global agricultural production. Livestock plays an essential role in maintaining food security as the sector contributes around 13% of calories and 28% of protein demands required by humans worldwide. Fertilization of tropical pastures with wood ash emerges as a sustainable practice that can contribute to better nutrient cycling, increased production, and reduced dependence on mineral resources. In this context, the aim of this study was to evaluate the production characteristics of two Panicum maximum grass cultivars fertilized with ash from wood grown in tropical soils of the Brazilian Cerrado. The experimental design was in randomized blocks in a factorial arrangement 5x2 with five doses of wood ash (0, 8, 16, 24, and 32 g kg-1) and two cultivars of Panicum maximum (cv. BRS Zuri and cv. Mombasa), with six replications. The experiment was carried out in 5 dm3 pots for 120 days. The wood ash used in the experiment comes from the combustion of eucalyptus (Eucalyptus sp.) logs in a boiler. The application of wood ash in acidic tropical soils increased leaf area, tillering, leaf dry mass, stem dry mass, and root volume in Mombasa and BRS Zuri cultivars of Panicum maximum grass, with maximum production at a dose of 32 g kg-1. The application of wood ash in acidic tropical soils offers potential as a sustainable strategy to increase production in forage production area for animal consumption in grazing, given the growing demand for beef. In addition, it properly and safely disposes of waste and recycles nutrients extracted by the crops.
A rare case of unilateral agenesis of left pulmonary artery presenting as severe pulmonary arterial hypertension
Authors: Malani Susheel Kumar , Kashyap Prashant , Nalawade Digvijay
Published: September 2023

A 26-year-old young male patient presented with progressive dyspnea over the previous 2 years. The patient also had pulmonary hypertension. Computed tomography (CT) pulmonary angiography showed absence of the left pulmonary artery, and conventional pulmonary and aortic root angiograms showed ipsilateral lung receiving collaterals from the left internal mammary artery and thyrocervical trunk.
Predictors of protein losing enteropathy after Fontan completion: An 8-year retrospective study at Sheikh Khalifa Medical City
Authors: AbdelMassih Antoine , Kiraly Laszlo , El Badaoui Hazem , Khan Mohammad , Hetharsi Balazs , Till Judit , Omelchenko Aleksandr , Salah Alaa , Al Jburi Farah , Alkhouli Laila , Taher Mina , Alhosani Najah , Youssef Omnia , Iqbal Sumaiya , Allami Zahraa , Jha Neerod , Hamad Eman , Omar Yasmin , Khan Arshad , Azeez Zafar , Attia Michael , Mina Mariam , Al Ali Alyaa , Afifi Yara , El Shershaby Meryam , Musleh Afnan
Published: September 2023

Background: The Fontan procedure is the final stage of a three-stage palliation process in patients born with a univentricular heart as part of hypoplastic left heart syndrome (HLHS) or other pathologies with a univentricular heart. As essential as this procedure has proven to be for such cases, the Fontan physiology diminishes cardiac output and expands systemic venous pressure, which then leads to venous congestion that can be complicated by protein-losing enteropathy (PLE). This retrospective study aimed to identify the predictors of such complications in all patients who underwent completion of the Fontan procedure at our center (Sheikh Khalifa Medical City/SKMC) in the past eight years.
Methods: This study examined the medical records of patients who underwent completion of Fontan repair at our center since the inauguration of the cardiac surgery program of SKMC in the United Arab Emirates (UAE). Exclusion criteria included the absence of any of the required predictors in a medical report. Patients were divided into two groups: those who developed PLE and those who did not. For each group, the following data were collected: degree of AV valve regurgitation, ventricular function, invasive SVC, pulmonary pressure before Fontan completion, and original cardiac diagnosis.
Results: Of the 48 included patients,13 (25%) developed PLE. Multivariate regression analysis showed that the best predictors of PLE were AV valve regurgitation (P=0.02), SVC mean pressure (P =0.006), and ventricular function (P =0.02). Oxygen saturation <83% prior to Fontan completion was 92% sensitive in predicting PLE after Fontan completion.
Conclusion: This is a single-center study of the predictors of PLE after Fontan procedure and, as expected from similar studies, moderate AV valve regurgutation and a dominant right ventricle were good predictors of Fontan failure. The higher prevalence of PLE in our cohort as well as lower cut-offs of SVC pressure that can predict complications might be related to the predominance of hypoplastic left heart in the operated patients, which has been the main referral center for cardiac surgeries in UAE in the last decade.
Early detection of reduced left ventricular systolic function by 2D speckle tracking echocardiography in patients with primary mitral regurgitation in a Vietnamese cohort
Authors: Nguyen Anh Vu , Nguyen Thi Diem , Ong Thi To Linh , Tran Viet An , Tran Lam Thai Bao , Tran Minh Chau
Published: September 2023

Background: Mitral regurgitation (MR) is a common heart valve disease, causing many serious complications in several organ systems, especially the cardiovascular system. The 2D speckle tracking echocardiography (STE) is a new technique for detecting potential cardiac dysfunction when only tissue function abnormalities are present. The study aimed to assess left ventricular (LV) systolic function early by STE in patients with primary MR through global LV deformity along the global longitudinal strain (GLS).
Methods: An analytical cross-sectional study was performed on 46 patients with moderate to severe primary MR as recommended by the American Society of Echocardiography (ASE) 2017.
Results: The prevalence of patients with GLS reduction with ejection fraction (EF) >60%, New York Heart Association (NYHA) I, and left ventricular internal diameter systolic (LVIDs) <40mm was 38.1%, 35.7%, and 39.5%, respectively. 100% of patients with EF<60% and LVIDs40mm had reduced GLS (<16%). The GLS index strongly correlates with the NYHA classification, degree of MR, EF, and echocardiographic parameters.
Conclusion: GLS index gives a significant sign in the early detection of cardiac function abnormalities before symptoms or other echocardiographic parameters in patients with MR.
Stress cardiomyopathy as a cardiovascular manifestation of COVID-19
Authors: Abdullah Khaled , Bakir Mohamad , Greenberg Danielle , Almasri Eyad
Published: September 2023

Patients with coronavirus disease 2019 (COVID-19) may present with a broad spectrum of clinical manifestations, affecting several organ systems. Commonly reported cardiac manifestations include myocardial injury, heart failure (HF), cardiogenic shock, and arrhythmias. Stress (takotsubo) cardiomyopathy, which is characterized by apical ballooning of the heart leading to acute left ventricular dysfunction, is rarely seen in patients with COVID-19. We present a case of COVID-19-associated stress cardiomyopathy in a female in her sixties.
Social Entrepreneurship Development Strategy
Authors: Febrianto Abi Sopyan , Khoirunnisa Rilla , Sudiro Achmad , Rahayu Mintarti
Published: September 2023

This study aimed to analyze the strategy of developing social entrepreneurship with the Social Impact Canvas method on Sahawood. This study used a qualitative method with a case study approach. Data collection method was done by using observation and interviews with four informants who were directly involved in the Sahawood business process. The Social Impact Canvas provides an overview of business development strategies contained in the components of anchor purpose; value prepositions; stakeholders; stakeholders relationship; channel; key activities; key resources; key partners; revenue streams; magnitude; costs; differentiation. The findings in this study indicate that the social value of Sahawood creates a strong brand story and becomes a strength in attracting consumers. As a social entrepreneurship, Sahawood was able to become a place for former addicts to change for the better and control the beneficiaries from using drugs again and committing criminal acts. Social Impact Canvas is not only describing business implementation but also highlighting social values and business uniqueness in social entrepreneurship. This study has implications for the development of Sahawood’s future business strategy.
Keeping Myth Memory Alive: The Usual and the Unusual in Sudha Murty’s Unusual Tales Series
Authors:   Associate Professor, Department of English, St. Andrew’s College of Arts, Science, and Commerce, Lobo Susan
Published: September 2023

If myth is vital to a community, its memory must be kept alive. But how, is the question? Is it always prudent to remain faithful to the ‘original’ version of the received myth, or is it desirable to tamper with, or destabilize, the source myth? In India, mainstream versions of the Ramayana and the Mahabharata have long been disrupted by folk, feminist, and queer adaptations. Reversions of these oral, transhistorical master narratives of Hinduism have made a resurgence in a post-independence India that is precariously perched between tradition and modernity, and hence more acutely desirous that its children veer closer to their roots, or so the flourishing market for myth retellings for children suggests. Amongst this incandescent body of literature is Sudha Murty’s series of five books that revisits popular stories about the gods and goddesses of the Hindu pantheon — The Serpent’s Revenge: Unusual Tales from the Mahabharata (2016), The Man from the Egg: Unusual Tales about the Trinity (2017), The Upside Down King: Unusual Tales about Rama and Krishna (2018), The Daughter from a Wishing Tree: Unusual Tales about Women in Mythology (2019), and The Sage with Two Horns: Unusual Tales from Mythology (2021). This paper explores how these tales of antiquity, refracted and reconstructed through the author’s own personal memory, intersect with the more public and collective myth memory of the community. In reviewing Murty’s retrieval of myths by reimagining and re-situating the ‘evidentiary traces’ of myth in the here and now for the children of today, it interrogates how, if at all, the retold myths counter the metanarratives of gender, religion, culture and perhaps, history too. Finally, it argues that the genre of myth retelling must go beyond simply reviving myth memory to destabilizing myth by ‘fiddling ‘with the sacred, especially when adapted for children.
Misjudging drinking water quality risk: Adopting a barrier approach for meaningful risk assessment to address latent risks
Authors: Walker Richard
Published: September 2023

The water quality risk assessment is the foundation for every drinking Water Safety Plan. The need to conform with a ‘Corporate’ risk assessment model commonly dominated by asset management frequency data can cause misjudgement of microbial risk. Well-performed risk assessments should identify potential risks. Risk assessments which place too much emphasis on historical evidence to demonstrate ‘likelihood’ of microbial contamination are unsuitable for drinking water quality because they fail to recognise ‘latent’ risks associated with absent or underperforming barriers to contamination. Most outbreaks occur when these ‘latent’ factors align to create a failure. Good risk assessments need to provide foresight. This is achieved if drinking water quality risk assessments are based on a ‘barrier’ approach. Where adequate and reliable multiple barriers to contamination are present the likelihood of a hazardous event should then be categorised as rare. Where barriers are absent, inadequate, or unreliable, then a higher likelihood is appropriate, depending on the nature and extent of the barrier shortfall. Practical examples show how the ‘barrier’ approach can be applied. The barrier risk assessment directly informs the operational monitoring programme, enabling regular confirmation that the challenge and barrier performance are consistent with the predictions of the risk assessment.
Analysis on influence of consolidation and settlement of deep silt soil on existing pipeline – take the project of the fourth water supply pipeline to Macao as an example
Authors: Song Jian , Zhao Xuguang , Xu Jin , Shang Zheng , Liu Dian , Pan Haijie
Published: September 2023

As time goes by in deep silt, the water in the shallow layers of the soil and the water pressure will both dissipate, causing greater deformation of the soil structure. Based on the analysis of the new pipeline in Zhuhai, the post-settlement of the existing pipeline in the silt is calculated by theoretical analysis and simulation. It is concluded that the displacement deformation of the water supply pipeline after 400 days of sediment consolidation is still in safety control and puts forward some optimization methods to ensure the safety and function of the pipeline and provide the guidance basis for the follow-up maintenance and construction. It has a certain practical value.
"Meteu essa, Cazé?": uma construção idiomática popularizada em práticas discursivas da internet
Authors: Furtado da Cunha Maria Angélica , Victor Pires Rodrigues Marcos
Published: September 2023

O objetivo deste estudo consiste em caracterizar uma construção idiomática inovadora do Português Brasileiro, [meter X], que tem sido popularizada recentemente em práticas discursivas da internet. Tal popularização se deve ao corrente sucesso das transmissões ao vivo do jovem streamer Casimiro, que costuma empregar a realização mais prototípica dessa construção, a expressão “meteu essa”. Toma-se como fundamentação teórica a Linguística Funcional Centrada no Uso e a Gramática de Construções. Por meio da análise de ocorrências coletadas na rede social Twitter, [meter X] é descrita em termos das propriedades de esquematicidade, produtividade e composicionalidade. Os resultados sugerem que [meter X] é totalmente opaca, parcialmente especificada e parcialmente produtiva. Foram constatadas três instâncias-type: [meter SN], [meter X ditransitiva] e [meter essa].
Three Decades of Targeting Falcipains to Develop Antiplasmodial
Agents: What have we Learned and What can be Done Next?
Authors: González Jorge Enrique Hernández , Salas-Sarduy Emir , Alvarez Lilian Hernández , Valiente Pedro Alberto , Arni Raghuvir Krishnaswamy , Pascutti Pedro Geraldo
Published: September 2023

Malaria is a devastating infectious disease that affects large swathes of human
populations across the planet’s tropical regions. It is caused by parasites of the genus
Plasmodium, with Plasmodium falciparum being responsible for the most lethal form of
the disease. During the intraerythrocytic stage in the human hosts, malaria parasites multiply
and degrade hemoglobin (Hb) using a battery of proteases, which include two cysteine
proteases, falcipains 2 and 3 (FP-2 and FP-3). Due to their role as major hemoglobinases,
FP-2 and FP-3 have been targeted in studies aiming to discover new antimalarials
and numerous inhibitors with activity against these enzymes, and parasites in culture
have been identified. Nonetheless, cross-inhibition of human cysteine cathepsins remains
a serious hurdle to overcome for these compounds to be used clinically. In this article,
we have reviewed key functional and structural properties of FP-2/3 and described different
compound series reported as inhibitors of these proteases during decades of active research
in the field. Special attention is also paid to the wide range of computer-aided
drug design (CADD) techniques successfully applied to discover new active compounds.
Finally, we provide guidelines that, in our understanding, will help advance the rational
discovery of new FP-2/3 inhibitors.