bluuebunny/crossref_metadata_2025 huggingface dataset:
Turbomachine Operation with Magnetic Bearings in Supercritical Carbon Dioxide Environment
Authors: Hacks Alexander Johannes , Brillert Dieter
Published: June 2022

In the sCO2-HeRo project, the Chair of Turbomachinery at the University of Duisburg-Essen developed, built and tested a turbomachine with an integral design in which the compressor, generator and turbine are housed in a single hermetic casing. However, ball bearings limited operation because their lubricants were incompatible with supercritical CO2 (sCO2) and they had to operate in gaseous CO2 instead. To overcome this problem, the turbomachine was redesigned built and tested in the sCO2-4-NPP project. Instead of ball bearings, magnetic bearings are now used to operate the turbomachine with the entire rotor in sCO2. This paper presents the revised design, focusing on the usage of magnetic bearings. It also investigates whether the sCO2 limits the operating range. Test runs show that increasing the density and rotational speed results in greater deflection of the rotor and greater forces on the bearings. Measurements are also analyzed with respect to influence of the density increase on the destabilizing forces in the rotor–stator cavities. The conclusion is that for the operation of the turbomachine, the control parameters of the magnetic bearings must be adjusted not only to the rotor speed, but also to the fluid density. This enabled successful operation of the turbomachine, which reached a speed of about 40,000 rpm during initial tests in CO2.
Sf-FGFR and Sf-SR-C Are Not the Receptors for Vip3Aa to Exert Insecticidal Toxicity in Spodoptera frugiperda
Authors: Shan Yinxue , Jin Minghui , Chakrabarty Swapan , Yang Bo , Li Qi , Cheng Ying , Zhang Lei , Xiao Yutao
Published: June 2022

Vip3Aa is a novel insecticidal protein secreted by Bacillus thuringiensis (Bt) during its vegetative growth stages. It has high insecticidal activity against lepidopteran pests such as Spodoptera frugiperda, and has no cross-resistance with Cry insecticidal proteins. As a new type of insecticide, it plays an important role in controlling agricultural pests. However, the insecticidal mechanism of the Vip3Aa toxin, especially its definite receptors, have not been fully revealed. In this study, the previously reported Vip3Aa receptor genes Sf-FGFR and Sf-SR-C were knocked out separately using the CRISPR/Cas9 system. Bioassay results showed that the sensitivity of these two knockout strains to Vip3Aa were not significantly changed compared to that of the normal strain. The current results are not consistent with the previously reports that Sf-SR-C and Sf-FGFR were the receptors of Vip3Aa in vitro. This suggests that the Sf-SR-C and Sf-FGFR genes we tested may not be critical in the mode of action of Vip3Aa in vivo in Spodoptera frugiperda.
Comparison between Vascular and Non-Vascular Bone Grafting in Scaphoid Nonunion: A Systematic Review
Authors: Testa Gianluca , Lucenti Ludovico , D’Amato Salvatore , Sorrentino Marco , Cosentino Pierluigi , Vescio Andrea , Pavone Vito
Published: June 2022

Background: Scaphoid fractures correspond to 60% of all carpal fractures, with a risk of 10% to progress towards non-union. Furthermore, ~3% present avascular necrosis (AVN) of the proximal pole, which is one of the main complications related to the peculiar vascularization of the bone. Scaphoid non-union can be treated with vascularized and non-vascularized bone grafting. The aim of the study is to evaluate the rates of consolidation of scaphoid non-union treated using two types of grafts. Methods: A systematic review of two electronic medical databases was carried out by two independent authors, using the following inclusion criteria: non-union of the proximal pole of the scaphoid bone, treated with vascular bone grafting (VBG) or non-vascular bone grafting (NVBG), with or without the use of internal fixation, patients aged ≥ 10 years old, and a minimum of 12 months follow-up. Research of any level of evidence that reports clinical results and regarding non-union scaphoid, either using vascularized or non-vascularized bone grafting, has been included. Results: A total of 271 articles were identified. At the end of the first screening, 104 eligible articles were selected for the whole reading of the text. Finally, after reading the text and the control of the reference list, we selected 26 articles following the criteria described above. Conclusions: The choice of the VBG depends mainly on the defect of the scaphoid and on the surgeon’s knowledge of the different techniques. Free vascular graft with medial femoral condyle (MFC) seems to be a promising alternative to local vascularized bone grafts in difficult cases.
Reply to Dziewas, R.; Bath, P.M. Endpoints in Dysphagia Trials. Comment on “Speyer et al. Neurostimulation in People with Oropharyngeal Dysphagia: A Systematic Review and Meta-Analyses of Randomised Controlled Trials—Part I: Pharyngeal and Neuromuscular Electrical Stimulation. J. Clin. Med. 2022, 11, 776”
Authors: Speyer Renée , Sutt Anna-Liisa , Bergström Liza , Hamdy Shaheen , Heijnen Bas Joris , Remijn Lianne , Wilkes-Gillan Sarah , Cordier Reinie
Published: June 2022

Our systematic review and meta-analysis of pharyngeal electrical stimulation (PES) and neuromuscular electrical stimulation (NMES) in patients with oropharyngeal dysphagia (OD) is the first paper (Part I) [...]
Review of Contemporary Invasive Treatment Approaches and Critical Appraisal of Guidelines on Hypertrophic Obstructive Cardiomyopathy: State-of-the-Art Review
Authors: Lebowitz Steven , Kowalewski Mariusz , Raffa Giuseppe Maria , Chu Danny , Greco Matteo , Gandolfo Caterina , Mignosa Carmelo , Lorusso Roberto , Suwalski Piotr , Pilato Michele
Published: June 2022

Background: Hypertrophic obstructive cardiomyopathy (HOCM) is a heterogeneous disease with different clinical presentations, albeit producing similar dismal long-term outcomes if left untreated. Several approaches are available for the treatment of HOCM; e.g., alcohol septal ablation (ASA) and surgical myectomy (SM). The objectives of the current review were to (1) discuss the place of the standard invasive treatment modalities (ASA and SM) for HOCM; (2) summarize and compare novel techniques for the management of HOCM; (3) analyze current guidelines addressing HOCM management; and (4) offer suggestions for the treatment of complex HOCM presentations. Methods: We searched the literature and attempted to gather the most relevant and impactful available evidence on ASA, SM, and other invasive means of treatment of HOCM. The literature search yielded thousands of results, and 103 significant publications were ultimately included. Results: We critically analyzed available guidelines and provided context in the setting of patient selection for standard and novel treatment modalities. This review offers the most comprehensive analysis to-date of available invasive treatments for HOCM. These include the standard treatments, SM and ASA, as well as novel treatments such as dual-chamber pacing and radiofrequency catheter ablation. We also account for complex pathoanatomic presentations and current guidelines to offer suggestions for tailored care of patients with HOCM. Finally, we consider promising future therapies for HOCM. Conclusions: HOCM is a heterogeneous disease associated with poor outcomes if left untreated. Several strategies for treatment of HOCM are available but patient selection for the procedure is crucial.
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Colorectal Peritoneal Metastases: A Summary of Key Clinical Trials
Authors: Turner Kevin M. , Morris Mackenzie C. , Sohal Davendra , Sussman Jeffrey J. , Wilson Gregory C. , Ahmad Syed A. , Patel Sameer H.
Published: June 2022

The peritoneal cavity is a common site of metastatic spread from colorectal cancer (CRC). Patients with peritoneal metastases (PM) often have aggressive underlying tumor biology and poor survival. While only a minority of patients with CRC have potentially resectable disease, the high overall incidence of CRC makes management of PM a common clinical problem. In this population, cytoreductive surgery (CRS)-hyperthermic intraperitoneal chemotherapy (HIPEC) is the only effective therapy for appropriately selected patients. In this narrative review, we summarize the existing literature on CRS-HIPEC in colorectal PM. Recent prospective clinical trials have shown conflicting evidence regarding the benefit of HIPEC perfusion in addition to CRS. Current strategies to prevent PM in those at high-risk have been shown to be ineffective. Herein we will provide a framework for clinicians to understand and apply these data to treat this complex disease presentation.
Decreased Expression of CIRP Induced by Therapeutic Hypothermia Correlates with Reduced Early Brain Injury after Subarachnoid Hemorrhage
Authors: Dai Haibin , Zhou Yan , Lu Yue , Zhang Xiangsheng , Zhuang Zong , Gao Yongyue , Liu Guangjie , Chen Chunlei , Ma Jin , Li Wei , Hang Chunhua
Published: June 2022

Early brain injury is considered to be a primary reason for the poor prognosis of patients suffering from subarachnoid hemorrhage (SAH). Due to its pro-inflammatory activity, cold-inducible RNA-binding protein (CIRP) has been implicated in the ischemic brain insult, but its possible interplay with hypothermia in SAH treatment remains to be evaluated. One-hundred and thirty-eight Sprague-Dawley rats (300–350 g males) were randomly allocated into the following groups: sham-operated (Sham); SAH; and SAH + hypothermia (SAH + H), each comprised of 46 animals. After treatments, the brain tissues of the three groups were randomly collected after 12 h, 1 d, 3 d, and 7 d, and the expression levels of the CIRP and mitochondrial apoptosis pathway-related proteins Bax, Bcl-2, caspase-9, caspase-3, and cytochrome c measured using Western blotting and real-time PCR. Brain damage was assessed by TUNEL and Nissl staining, the electron microscopy of brain tissue slices as well as functional rotarod tests. Expression of CIRP, Bax, caspase-9, caspase-3, and cytochrome c as well as reduced motor function incidence were higher in the SAH group, particularly during the first 3 d after SAH induction. Hypothermia blunted these SAH responses and apoptosis, thereby indicating reduced inflammatory signaling and less brain cell injury in the early period after SAH. Hypothermia treatment was found to effectively protect the brain tissue from early SAH injury in a rat model and its further evaluation as a therapeutic modality in SAH patients requires further study.
The Clinical Relevance of Hypothyroidism in Patients with Solid Non-Thyroid Cancer: A Tantalizing Conundrum
Authors: Deligiorgi Maria V. , Trafalis Dimitrios T.
Published: June 2022

Hypothyroidism in patients with solid non-thyroid cancer is a tantalizing entity, integrating an intriguing thyroid hormones (THs)–cancer association with the complexity of hypothyroidism itself. The present narrative review provides a comprehensive overview of the clinical relevance of hypothyroidism in solid non-thyroid cancer. Hypothyroidism in patients with solid non-thyroid cancer is reminiscent of hypothyroidism in the general population, yet also poses distinct challenges due to the dual role of THs in cancer: promoting versus inhibitory. Close collaboration between oncologists and endocrinologists will enable the prompt and personalized diagnosis and treatment of hypothyroidism in patients with solid non-thyroid cancer. Clinical data indicate that hypothyroidism is a predictor of a decreased or increased risk of solid non-thyroid cancer and is a prognostic factor of favorable or unfavorable prognosis in solid non-thyroid cancer. However, the impact of hypothyroidism with respect to the risk and/or prognosis of solid non-thyroid cancer is not a consistent finding. To harness hypothyroidism, or THs replacement, as a personalized anticancer strategy for solid non-thyroid cancer, four prerequisites need to be fulfilled, namely: (i) deciphering the dual THs actions in cancer; (ii) identifying interventions in THs status and developing agents that block tumor-promoting THs actions and/or mimic anticancer THs actions; (iii) appropriate patient selection; and (iv) counteracting current methodological limitations.
Surgery for Aortic Prosthetic Valve Endocarditis in the Transcatheter Era
Authors: Saha Shekhar , Ali Ahmad , Schnackenburg Philipp , Horke Konstanze Maria , Oberbach Andreas , Schlichting Nadine , Sadoni Sebastian , Rizas Konstantinos , Braun Daniel , Luehr Maximilian , Bagaev Erik , Hagl Christian , Joskowiak Dominik
Published: June 2022

Objectives: As surgical experience with infective endocarditis following transcatheter aortic valve replacement is scarce, this study compared the perioperative and short-term outcomes of patients suffering from endocarditis following surgical aortic valve replacement and transcatheter aortic valve replacement. Methods: Between January 2013 and December 2020, 468 consecutive patients were admitted to our center for surgery for IE. Among them, 98 were operated on for endocarditis following surgical aortic valve replacement and 22 for endocarditis following transcatheter aortic valve replacement. Results: The median EuroSCORE II (52.1 (40.6–62.0) v/s 45.4 (32.6–58.1), p = 0.207) and STS-PROM (1.8 (1.6–2.1) v/s 1.9 (1.4–2.2), p = 0.622) were comparable. Endocarditis following transcatheter aortic valve replacement accounted for 13.7% of the aortic prosthetic valve endocarditis between 2013 and 2015; this increased to 26.9% in the years 2019 and 2020.Concomitant procedures were performed in 35 patients (29.2%). The operative mortality was 26.5% in the endocarditis following surgical aortic valve replacement group and 9.1% in the endocarditis following transcatheter aortic valve replacement group (p = 0.098). Upon follow-up, survival at 6 months was found to be 98% in the group with endocarditis following surgical aortic valve replacement and 89% in the group with endocarditis following transcatheter aortic valve replacement (p = 0.081). Conclusions: Patients suffering from endocarditis following surgical aortic valve replacement and transcatheter aortic valve replacement present with comparable risk profiles and can be surgically treated with comparable results. Surgery as a curative option should not be rejected even in this intermediate-risk cohort.
The Hypertensive Disorders of Pregnancy: A Focus on Definitions for Clinical Nephrologists
Authors: Longhitano Elisa , Siligato Rossella , Torreggiani Massimo , Attini Rossella , Masturzo Bianca , Casula Viola , Matarazzo Ida , Cabiddu Gianfranca , Santoro Domenico , Versino Elisabetta , Piccoli Giorgina Barbara
Published: June 2022

About 5–10% of pregnancies are complicated by one of the hypertensive disorders of pregnancy. The women who experience these disorders have a greater risk of having or developing kidney diseases than women with normotensive pregnancies. While international guidelines do not provide clear indications for a nephrology work-up after pregnancy, this is increasingly being advised by nephrology societies. The definitions of the hypertensive disorders of pregnancy have changed greatly in recent years. The objective of this short review is to gather and comment upon the main definitions of the hypertensive disorders of pregnancy as a support for nephrologists, who are increasingly involved in the short- and long-term management of women with these disorders.
Evaluation of Atopic Dermatitis and Cutaneous Infectious Disorders Using Sequential Pattern Mining: A Nationwide Population-Based Cohort Study
Authors: Han Ju-Hee , Yoon Jae-Woong , Yook Hwa-Jung , Bang Chul-Hwan , Chun Jae-Hun , Lee Jun-Young , Park Young-Min , Lee Suk-Jun , Lee Ji-Hyun
Published: June 2022

According to previous studies, the increased risk of cutaneous infectious disorders in patients with atopic dermatitis (AD) is related to impaired epidermal function, abnormal systemic immune function, and lower antimicrobial peptides. In this study, we analyzed the association between AD and cutaneous infectious disorders in the real world using sequential pattern mining (SPM). We analyzed National Health Insurance data from 2010–2013 using SPM to identify comorbid cutaneous infectious diseases and the onset durations of comorbidities. Patients with AD were at greater risk for molluscum contagiosum (adjusted odds ratio (aOR), 5.273), impetigo (aOR, 2.852), chickenpox (aOR, 2.251), otitis media (aOR, 1.748), eczema herpeticum (aOR, 1.292), and viral warts (aOR, 1.105). In SPM analysis, comorbidity of 1.06% shown in molluscum contagiosum was the highest value, and the duration of 77.42 days documented for molluscum contagiosum was the shortest onset duration among all the association rules. This study suggests that AD is associated with an increased risk of cutaneous infectious disorders. In particular, care should be taken regarding its high relevance with impetigo, molluscum contagiosum, and otitis media, which may help in preventing AD from worsening through appropriately preventing and managing the condition.
Preventive Health Screening during the COVID-19 Pandemic: A Cross-Sectional Survey among 102,928 Internet Users in Poland
Authors: Mularczyk-Tomczewska Paulina , Żarnowski Adam , Gujski Mariusz , Sytnik-Czetwertyński Janusz , Pańkowski Igor , Smoliński Rafał , Jankowski Mateusz
Published: June 2022

Preventive screening is a highly cost-effective public health intervention. The COVID-19 pandemic may impact preventive healthcare services. This study aimed to assess the frequency of preventive health screening, as well as to identify the factors associated with compliance with health screening guidelines among adults in Poland during the COVID-19 pandemic. This cross-sectional survey was carried out between October and December 2021, among Internet users in Poland. Respondents were asked about the last date that they performed seven different screening tests. Completed questionnaires were obtained from 102,928 adults aged 18–99 years, and 57.2% were female. The most common screening tests performed in the past 12 months were blood pressure measurement (83%), blood count (66.2%), and blood sugar (63.3%). Moreover, more than half of respondents had a urinalysis (53.1%) and lipid panel (55.1%) in the past 12 months. Out of 58,904 females, 69.2% had a cervical cytology in the past 3 years. Older age, having higher education, living in urban areas, being occupationally active, having at least one chronic disease, and visiting a doctor in the past 12 months were significantly associated (p < 0.001) with a higher level of compliance with screening guidelines. This study revealed a significant gap in the performance of preventive health screening.
Optical Impact of Corneal Clearance in Healthy Eyes Fitted with Scleral Contact Lenses: A Pilot Study
Authors: Villa María , Cavas Francisco , Piñero David P.
Published: June 2022

This pilot study was conducted to evaluate the effect on refraction and optical quality of the increase in the corneal clearance after fitting a specific model of scleral contact lens (ScCL) in healthy subjects. A total of 15 eyes from 15 subjects were enrolled in the study, with evaluation of refraction, ocular aberrations and central corneal clearance with the same model of ScCL (ICD Toric, Paragon Vision Science, Gilbert, AZ, USA), but using 3 different sagittal heights: 4200, 4500 and 4800 µm. Mean values of corneal clearance for each ScCL fitted were 418.1 ± 112.1, 706.5 ± 120.3 and 989.9 ± 117.0 µm, respectively. Significant changes were detected in the spherical equivalent and high-order aberrations, especially coma and spherical aberration, when fitting ScCLs of increasing sagittal heights compared to the pre-fitting values. In conclusion, the increase in central corneal clearance when fitting ScCLs affects refraction, leading to a more myopic refractive error, and inducing an increase in different ocular HOAs. This should be considered when fitting ScCLs, especially multifocal designs.
Long-Term Variations in Retinal Parameters after Uncomplicated Cataract Surgery
Authors: Gawęcki Maciej , Prądzyńska Natalia , Karska-Basta Izabella
Published: June 2022

Background: Cataract phacoemulsification surgery provides excellent refractive results; however, it also elicits changes in the posterior segment of the eye. This study aimed to determine changes in retinal parameters measured by spectral-domain optical coherence tomography (SD-OCT) and OCT angiography (OCTA) after an uncomplicated cataract surgery, including the impact of effective phacoemulsification time (EPT). Methods: The study included 44 patients without retinal abnormalities, followed up after unilateral uncomplicated cataract phacoemulsification in a single ophthalmological unit. Patients were evaluated for the following parameters at baseline and at 2 weeks, 3 months, and 12 months after the surgery: best corrected visual acuity, central retinal thickness (CRT), average central retinal thickness (CRTA), central retinal volume (cube volume (CV)), vessel density central (VDC), vessel density full (VDF), vessel perfusion central (VPC), and vessel perfusion full (VPF). The EPT recorded at each procedure was used as a covariant for the evaluation of changes in retinal parameters after the surgery. Analysis included 44 eyes for SD-OCT and 17 for OCTA evaluation, according to adopted scan quality thresholds. Results: A significant increase in CRT, CRTA, and CV was noted at each follow-up point compared with baseline. The rising tendency was observed in the first 3 months after the surgery, with a decline over the subsequent months. The VPF parameter showed a stable improvement after the surgery. The analysis of covariance did not confirm any significant effect of the EPT on variations in CRT, CV, CRTA, VDC, and VPF and there was a weak effect on the VDF parameter. Conclusions: Uncomplicated cataract surgery results in an increase in retinal thickness and volume in the first few months after the surgery, followed by a spontaneous decline in these parameters in the subsequent months. A long-standing improvement is noted in the VPF parameter.
De Novo Transcriptome Sequencing and Analysis of Differential Gene Expression among Various Stages of Tail Regeneration in Hemidactylus flaviviridis
Authors: Patel Sonam , Ranadive Isha , Buch Pranav , Khaire Kashmira , Balakrishnan Suresh
Published: June 2022

Across the animal kingdom, lizards are the only amniotes capable of regenerating their lost tail through epimorphosis. Of the many reptiles, the northern house gecko, Hemidactylus flaviviridis, is an excellent model system that is used for understanding the mechanism of epimorphic regeneration. A stage-specific transcriptome profile was generated in the current study following an autotomized tail with the HiSeq2500 platform. The reads obtained from de novo sequencing were filtered and high-quality reads were considered for gene ontology (GO) annotation and pathway analysis. Millions of reads were recorded for each stage upon de novo assembly. Up and down-regulated transcripts were categorized for early blastema (EBL), blastema (BL) and differentiation (DF) stages compared to the normal tail (NT) by differential gene expression analysis. The transcripts from developmentally significant pathways such as FGF, Wnt, Shh and TGF-β/BMP were present during tail regeneration. Additionally, differential expression of transcripts was recorded from biological processes, namely inflammation, cell proliferation, apoptosis and cell migration. Overall, the study reveals the stage-wise transcriptome analysis in conjunction with cellular processes as well as molecular signaling pathways during lizard tail regeneration. The knowledge obtained from the data can be extrapolated to configure regenerative responses in other amniotes, including humans, upon loss of a complex organ.
Osteoconductive Silk Fibroin Binders for Bone Repair in Alveolar Cleft Palate: Fabrication, Structure, Properties, and In Vitro Testing
Authors: Sangkert Supaporn , Juncheed Kantida , Meesane Jirut
Published: June 2022

Osteoconductive silk fibroin (SF) binders were fabricated for the bone repair of an alveolar cleft defect. Binders were prefigureared by mixing different ratios of a mixture of random coils and SF aggregation with SF fibrils: 100:0 (SFB100), 75:25 (SFB75), 50:50 (SFB50), 25:75 (SFB25), and 0:100 (SFB0). The gelation, molecular organization, structures, topography, and morphology of the binders were characterized and observed. Their physical, mechanical, and biological properties were tested. The SF binders showed gelation via self-assembly of SF aggregation and fibrillation. SFB75, SFB50, and SFB25 had molecular formation via the amide groups and showed more structural stability than SFB100. The morphology of SFB0 demonstrated the largest pore size. SFB0 showed a lowest hydrophilicity. SFB100 showed the highest SF release. SFB25 had the highest maximum load. SFB50 exhibited the lowest elongation at break. Binders with SF fibrils showed more cell viability and higher cell proliferation, ALP activity, calcium deposition, and protein synthesis than without SF fibrils. Finally, the results were deduced: SFB25 demonstrated suitable performance that is promising for the bone repair of an alveolar cleft defect.
A Deep-Learning Model for Real-Time Red Palm Weevil Detection and Localization
Authors: Alsanea Majed , Habib Shabana , Khan Noreen Fayyaz , Alsharekh Mohammed F. , Islam Muhammad , Khan Sheroz
Published: June 2022

Background and motivation: Over the last two decades, particularly in the Middle East, Red Palm Weevils (RPW, Rhynchophorus ferruginous) have proved to be the most destructive pest of palm trees across the globe. Problem: The RPW has caused considerable damage to various palm species. The early identification of the RPW is a challenging task for good date production since the identification will prevent palm trees from being affected by the RPW. This is one of the reasons why the use of advanced technology will help in the prevention of the spread of the RPW on palm trees. Many researchers have worked on finding an accurate technique for the identification, localization and classification of the RPW pest. This study aimed to develop a model that can use a deep-learning approach to identify and discriminate between the RPW and other insects living in palm tree habitats using a deep-learning technique. Researchers had not applied deep learning to the classification of red palm weevils previously. Methods: In this study, a region-based convolutional neural network (R-CNN) algorithm was used to detect the location of the RPW in an image by building bounding boxes around the image. A CNN algorithm was applied in order to extract the features to enclose with the bounding boxes—the selection target. In addition, these features were passed through the classification and regression layers to determine the presence of the RPW with a high degree of accuracy and to locate its coordinates. Results: As a result of the developed model, the RPW can be quickly detected with a high accuracy of 100% in infested palm trees at an early stage. In the Al-Qassim region, which has thousands of farms, the model sets the path for deploying an efficient, low-cost RPW detection and classification technology for palm trees.
Spectral Analysis of Flow around Single and Two Crossing Circular Cylinders Arranged at 60 and 90 Degrees
Authors: Wang Tianyuan , Yang Qingqing , Tang Yeting , Shi Hongda , Zhang Qin , Wang Mengfei , Epikhin Andrey , Britov Andrey
Published: June 2022

Two modal decomposition techniques, including proper orthogonal decomposition (POD) and dynamic mode decomposition (DMD), were used to identify the wake patterns past single and two crossing cylinders in 60° and 90° arrangements with gap ratio G = 4. The flow was simulated using direct numerical simulations (DNS) for Reynolds numbers Re = 100. From modal analysis, the flow’s spatial scale decreased with increasing modal frequency. Two main modes were identified in the wake of the cylinders, namely spatially antisymmetric and symmetric modes. Antisymmetric and symmetric modes were related to the cylinders’ vortex shedding and shedding vortices’ shift motion, respectively, whose frequencies were odd and even multiples of the cylinders’ lift force frequency. In addition, a low-frequency mode concerning the shadowing effect of the downstream cylinder (DC) in 90° arrangement was found in the wake of the DC centre.
A Prototype Design and Sea Trials of an 11,000 m Autonomous and Remotely-Operated Vehicle Dream Chaser
Authors: Jiang Zhe , Lu Bin , Wang Biao , Cui Weicheng , Zhang Jinfei , Luo Ruilong , Luo Gaosheng , Zhang Shun , Mao Zhongjun
Published: June 2022

To better study the biology and ecology of hadal trenches for marine scientists, the Hadal Science and Technology Research Center (HAST) of Shanghai Ocean University proposed to construct a movable laboratory that includes a mothership, several full-ocean-depth (FOD) submersibles, and FOD landers to obtain samples in the hadal trenches. Among these vehicles, the project of an FOD autonomous and remotely-operated vehicle (ARV) named “Dream Chaser” was started in July 2018. The ARV could work in both remotely-operated and autonomous-operated modes, and serves large-range underwater observation, on-site sampling, surveying, mapping, etc. This paper proposed a novel three-body design of the FOD ARV. A detailed illustration of the whole system design method is provided. Numerical simulations and experimental tests for various sub-systems and disciplines have been conducted, such as resistance analysis using the computational fluid mechanics method and structural strength analysis for FOD hydrostatic pressure using the finite element method and pressure chamber tests. In addition, components tests and the entire system tests have been performed on land, underwater, and in the pressure chamber in the laboratory of HAST, and the results are discussed. Extensive experiments of two critical components, i.e., the thrusters and ballast-abandoning system, have been conducted and further analyzed in this paper. Finally, the procedures and results of lake trials, South China Sea trials and the first phase of Mariana Trench sea trials of the ARV in 2020 are also introduced. This paper provides a design method for the novel three-body FOD ARV. More importantly, the lessons learned from the FOD pressure test, lake tests, and sea trials, no matter the success or failure, will guide future endeavors and the application of ARV Dream Chaser and underwater vehicles of this kind.
Comparative Study on Added Resistance and Seakeeping Performance of X-Bow and Wave-Piercing Monohull in Regular Head Waves
Authors: Chen Shuling , Zou Beilei , Han Changzhi , Yan Shiqiang
Published: June 2022

Bow shape has been recognized as an important factor influencing the seakeeping performance and added resistance of ships. This paper presents a numerical comparative study on added resistance and seakeeping of model ships with ‘X-bow’ and a wave-piercing monohull in regular head waves using a computational fluid dynamics (CFD) software. Different wave heights, wavelengths and forward speeds are considered in the systematic investigation in order to characterize the added resistance and wave-induced motions, and to explore the local wave patterns. The results show a considerably different hydrodynamic characteristic by different bow shapes.
Collision-Avoidance Decision System for Inland Ships Based on Velocity Obstacle Algorithms
Authors: Zhang Guangyu , Wang Yan , Liu Jian , Cai Wei , Wang Hongbo
Published: June 2022

Due to the complex hydrology and narrow channels of inland rivers, ship collision accidents occur frequently. The traditional collision-avoidance algorithms are often aimed at sea areas, and not often at inland rivers. To solve the problem of inland-ship collision avoidance, this paper proposes an inland-ship collision-avoidance decision system based on the velocity obstacle algorithm. The system is designed to assist ships in achieving independent collision-avoidance operations under the limitation of maneuverability while meeting inland-ship collision-avoidance regulations. First, the paper improves the Maneuvering Modeling Group (MMG) model suitable for inland rivers. Then, it improves velocity obstacle algorithms based on the dynamic ship domain, which can deal with different obstacles and three encounter situations (head-on, crossing, and overtaking situations). In addition, this paper proposes a method to deal with close-quarters situations. Finally, the simulation environment built by MATLAB software is used to simulate the collision avoidance of inland ships against different obstacles under different situations with a decision-making time of less than 0.1 s. Through the analysis of the simulation results, the effectiveness and practicability of the system are verified, which can provide reasonable collision-avoidance decisions for inland ships.
Optimizing the Voce–Chaboche Model Parameters for Fatigue Life Estimation of Welded Joints in High-Strength Marine Structures
Authors: Petry Alice , Gallo Pasquale , Remes Heikki , Niemelä Ari
Published: June 2022

This work studies the Voce–Chaboche (V–C) material model parameter optimization for high-strength steel welded joints subjected to cyclic loading. The model parameters of each material zone in a S690 steel butt-welded joint were determined using an optimization algorithm based on the Newton trust region (NTR) method and an accumulated true strain parameter. The model parameters were fitted to stress–strain histories from uniaxial strain-controlled cyclic tests. To validate the model, fully-reversed variable amplitude fatigue experiments were performed under load control. The experimental results were then compared to numerical results from a finite element analysis. When the elastic modulus is optimized as a V–C parameter, the results indicate that the V–C model slightly underestimates the strain range, leading to conservative fatigue life estimates. However, the results can be improved by using an elastic modulus obtained experimentally. In this case, the resulting material model slightly overestimates the strain range, leading to a non-conservative, but more accurate, fatigue life estimation. It can be concluded that the NTR-based accumulated true strain approach successfully determined the V–C model parameters for different material zones in the welded joint, and closely estimated the strain range and the fatigue life for a variable amplitude load history.
Leaf-Associated Epiphytic Fungi of Gingko biloba, Pinus bungeana and Sabina chinensis Exhibit Delicate Seasonal Variations
Authors: Bao Lijun , Sun Bo , Liu Jiayu , Zhang Shiwei , Xu Nan , Zhang Xiaoran , Bohu Tsing , Bai Zhihui
Published: June 2022

Plant-leaf surface on Earth harbors complex microbial communities that influence plant productivity and health. To gain a detailed understanding of the assembly and key drivers of leaf microbial communities, especially for leaf-associated fungi, we investigated leaf-associated fungal communities in two seasons for three plant species at two sites by high-throughput sequencing. The results reveal a strong impact of growing season and plant species on fungal community composition, exhibiting clear temporal patterns in abundance and diversity. For the deciduous tree Gingko biloba, the number of enriched genera in May was much higher than that in October. The number of enriched genera in the two evergreen trees Pinus bungeana and Sabina chinensis was slightly higher in October than in May. Among the genus-level biomarkers, the abundances of Alternaria, Cladosporium and Filobasidium were significantly higher in October than in May in the three tree species. Additionally, network correlations between the leaf-associated fungi of G. biloba were more complex in May than those in October, containing extra negative associations, which was more obvious than the network correlation changes of leaf-associated fungi of the two evergreen plant species. Overall, the fungal diversity and community composition varied significantly between different growing seasons and host plant species.
Plant Beneficial Bacteria as Bioprotectants against Wheat and Barley Diseases
Authors: Dutilloy Emma , Oni Feyisara Eyiwumi , Esmaeel Qassim , Clément Christophe , Barka Essaid Ait
Published: June 2022

Wheat and barley are the main cereal crops cultivated worldwide and serve as staple food for a third of the world’s population. However, due to enormous biotic stresses, the annual production has significantly reduced by 30–70%. Recently, the accelerated use of beneficial bacteria in the control of wheat and barley pathogens has gained prominence. In this review, we synthesized information about beneficial bacteria with demonstrated protection capacity against major barley and wheat pathogens including Fusarium graminearum, Zymoseptoria tritici and Pyrenophora teres. By summarizing the general insights into molecular factors involved in plant-pathogen interactions, we show to an extent, the means by which beneficial bacteria are implicated in plant defense against wheat and barley diseases. On wheat, many Bacillus strains predominantly reduced the disease incidence of F. graminearum and Z. tritici. In contrast, on barley, the efficacy of a few Pseudomonas, Bacillus and Paraburkholderia spp. has been established against P. teres. Although several modes of action were described for these strains, we have highlighted the role of Bacillus and Pseudomonas secondary metabolites in mediating direct antagonism and induced resistance against these pathogens. Furthermore, we advance a need to ascertain the mode of action of beneficial bacteria/molecules to enhance a solution-based crop protection strategy. Moreover, an apparent disjoint exists between numerous experiments that have demonstrated disease-suppressive effects and the translation of these successes to commercial products and applications. Clearly, the field of cereal disease protection leaves a lot to be explored and uncovered.
A Global Overview of Diversity and Phylogeny of the Rust Genus Uromyces
Authors: Gautam Ajay Kumar , Avasthi Shubhi , Verma Rajnish Kumar , Sushma  , Niranjan Mekala , Devadatha Bandarupalli , Jayawardena Ruvishika S. , Suwannarach Nakarin , Karunarathna Samantha C.
Published: June 2022

Uromyces is the second-largest plant pathogenic rust genus, is responsible for numerous diseases, and has major effects on both agricultural and non-agricultural plants. The genus is generally characterized by its unicellular teliospores that help to characterize it and distinguish it from another important rust genus, Puccinia. In this study, a global overview of the diversity and distribution of Uromyces is presented based on both online and offline resources. The information obtained was analyzed for numerical and graphical summaries to provide the diversity and distribution of the genus by country and continent. Besides this, broad taxonomical aspects, a brief life cycle, and other comparative aspects on diversity and distribution were also provided. In addition, a phylogenetic analysis based on the ITS and nLSU DNA sequence data available in GenBank and published literature was performed to examine the intergeneric relationships of Uromyces. The results obtained revealed that the rust genus is found distributed over 150 countries, territories, and occupancies of the world on around 647 plant genera belonging to 95 plant families. Phylogenetic studies based on LSU and ITS sequence data revealed that Uromyces species are polyphyletic and require more DNA-based analyses for a better understanding of their taxonomic placement.
Machine Learning Algorithm-Based Prediction Model for the Augmented Use of Clozapine with Electroconvulsive Therapy in Patients with Schizophrenia
Authors: Oh Hong Seok , Lee Bong Ju , Lee Yu Sang , Jang Ok-Jin , Nakagami Yukako , Inada Toshiya , Kato Takahiro A. , Kanba Shigenobu , Chong Mian-Yoon , Lin Sih-Ku , Si Tianmei , Xiang Yu-Tao , Avasthi Ajit , Grover Sandeep , Kallivayalil Roy Abraham , Pariwatcharakul Pornjira , Chee Kok Yoon , Tanra Andi J. , Rabbani Golam , Javed Afzal , Kathiarachchi Samudra , Myint Win Aung , Cuong Tran Van , Wang Yuxi , Sim Kang , Sartorius Norman , Tan Chay-Hoon , Shinfuku Naotaka , Park Yong Chon , Park Seon-Cheol
Published: June 2022

The augmentation of clozapine with electroconvulsive therapy (ECT) has been an optimal treatment option for patients with treatment- or clozapine-resistant schizophrenia. Using data from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics survey, which was the largest international psychiatry research collaboration in Asia, our study aimed to develop a machine learning algorithm-based substantial prediction model for the augmented use of clozapine with ECT in patients with schizophrenia in terms of precision medicine. A random forest model and least absolute shrinkage and selection operator (LASSO) model were used to develop a substantial prediction model for the augmented use of clozapine with ECT. Among the 3744 Asian patients with schizophrenia, those treated with a combination of clozapine and ECT were characterized by significantly greater proportions of females and inpatients, a longer duration of illness, and a greater prevalence of negative symptoms and social or occupational dysfunction than those not treated. In the random forest model, the area under the curve (AUC), which was the most preferred indicator of the prediction model, was 0.774. The overall accuracy was 0.817 (95% confidence interval, 0.793–0.839). Inpatient status was the most important variable in the substantial prediction model, followed by BMI, age, social or occupational dysfunction, persistent symptoms, illness duration > 20 years, and others. Furthermore, the AUC and overall accuracy of the LASSO model were 0.831 and 0.644 (95% CI, 0.615–0.672), respectively. Despite the subtle differences in both AUC and overall accuracy of the random forest model and LASSO model, the important variables were commonly shared by the two models. Using the machine learning algorithm, our findings allow the development of a substantial prediction model for the augmented use of clozapine with ECT in Asian patients with schizophrenia. This substantial prediction model can support further studies to develop a substantial prediction model for the augmented use of clozapine with ECT in patients with schizophrenia in a strict epidemiological context.
Association of General Anesthesia and Neuraxial Anesthesia in Caesarean Section with Maternal Postpartum Depression: A Retrospective Nationwide Population-Based Cohort Study
Authors: Hung Kuo-Hsun , Tsao Shao-Lun , Yang Shun-Fa , Wang Bo-Yuan , Huang Jing-Yang , Li Wen-Tyng , Yeh Liang-Tsai , Lin Cheng-Hung , Chen Yin-Yang , Yeh Chao-Bin
Published: June 2022

Although cesarean section (CS) has become a common method of child delivery in recent decades, the choice between general anesthesia (GA) and neuraxial anesthesia (NA) for CS must be carefully considered. Depending on the type of anesthesia used in CS, a major outcome observed is the occurrence of postpartum depression (PPD). This study investigated the association between PPD risk and the anesthesia method used in CS by using data from three linked nationwide databases in Taiwan, namely, the National Health Insurance Research Database, the National Birth Reporting Database, and the National Death Index Database. After propensity score matching by baseline depressive disorders, maternal demographics, status at delivery, infant’s health, maternal diseases during pregnancy, and age of partner, we included women who had natural births (n = 15,706), cesarean sections with GA (n = 15,706), and cesarean sections with NA (n = 15,706). A conditional logistic regression was used to estimate the odds ratios and 95% confidence intervals (CIs) of PPDs, including depression, sleep disorder, and medication with hypnotics or antidepressants, under anesthesia during CS. The prevalence rates of combined PPDs were 26.66%, 43.87%, and 36.30% in natural births, CS with GA, and CS with NA, respectively. In particular, the proportions of postpartum use of hypnotic drugs or antidepressants were 21.70%, 39.77%, and 31.84%, which were significantly different. The aORs (95% CIs) were 2.15 (2.05–2.25) for the included depressive disorders, 1.10 (1.00–1.21) for depression, 1.03 (0.96–1.11) for sleep disorder, and 2.38 (2.27–2.50) for medication with hypnotics or antidepressants in CS with GA compared with natural births. Women who underwent CS with GA had a significantly higher risk of depressive disorders and a higher need for antidepressants for sleep problems than those who underwent CS with NA. The risks of PPD were significantly associated with the anesthesia method, especially GA. Our results can assist physicians in carefully considering the appropriate anesthesia method for CS delivery, particularly with regard to postpartum drug abuse and drug safety.
A Framework for Comparative Assessment of Indigenous Land Governance
Authors: McDonald Chris , Figueiredo Lorena
Published: June 2022

Indigenous peoples are increasingly important players in the management and use of land and natural landscapes, bound in spiritual and traditional practices that endure and pre-date colonisation. This also extends to the aspirations that Indigenous traditional owners may have to generate income from land and to sustain business and employment opportunities that enable reinvestment in local communities. The paper draws from a study undertaken while the authors were at the Organisation of Economic Co-operation and Development (OECD) that involved 13 countries. It presents a framework to compare Indigenous land governance, to activate economic development opportunities across different legal and institutional contexts. The three-part typology allows us to assess the level of autonomy granted to Indigenous groups by law and identify key governance and regulatory instruments that they can employ to protect their cultural practices and activate commercial potential from land and waters. Varying autonomy levels can co-exist within a same country, since Indigenous groups may have different rights, aspirations, and capabilities. The typology allows us to conduct comparative analyses around progress and learnings that can support the self-determination of Indigenous peoples and promote regional well-being.
Differences and Similarities between the Lung Transcriptomic Profiles of COVID-19, COPD, and IPF Patients: A Meta-Analysis Study of Pathophysiological Signaling Pathways
Authors: Aguilar Daniel , Bosacoma Adelaida , Blanco Isabel , Tura-Ceide Olga , Serrano-Mollar Anna , Barberà Joan Albert , Peinado Victor Ivo
Published: June 2022

Coronavirus disease 2019 (COVID-19) is a pandemic respiratory disease associated with high morbidity and mortality. Although many patients recover, long-term sequelae after infection have become increasingly recognized and concerning. Among other sequelae, the available data indicate that many patients who recover from COVID-19 could develop fibrotic abnormalities over time. To understand the basic pathophysiology underlying the development of long-term pulmonary fibrosis in COVID-19, as well as the higher mortality rates in patients with pre-existing lung diseases, we compared the transcriptomic fingerprints among patients with COVID-19, idiopathic pulmonary fibrosis (IPF), and chronic obstructive pulmonary disease (COPD) using interactomic analysis. Patients who died of COVID-19 shared some of the molecular biological processes triggered in patients with IPF, such as those related to immune response, airway remodeling, and wound healing, which could explain the radiological images seen in some patients after discharge. However, other aspects of this transcriptomic profile did not resemble the profile associated with irreversible fibrotic processes in IPF. Our mathematical approach instead showed that the molecular processes that were altered in COVID-19 patients more closely resembled those observed in COPD. These data indicate that patients with COPD, who have overcome COVID-19, might experience a faster decline in lung function that will undoubtedly affect global health.