bluuebunny/crossref_metadata_2025 huggingface dataset:
Gingival recession and oral health‐related quality of life: a population‐based cross‐sectional study in Brazil
Authors: Wagner Tassiane P. , Costa Ricardo S. A. , Rios Fernando S. , Moura Mauricio S. , Maltz Marisa , Jardim Juliana J. , Haas Alex N.
Published: March 2016

Objectives

To assess the association between gingival recession (GR) and oral health‐related quality of life (OHRQoL) in a Brazilian population of adults.

Methods

A representative sample from Porto Alegre city was drawn in 2011 using a multistage probability sampling strategy. For this study, 740 individuals, 35–59 years of age and with ≥6 teeth, were included. GR was assessed by two calibrated examiners at four sites in all present teeth. The Oral Health Impact Profile (OHIP‐14) was used to assess OHRQoL. OHIP‐14 was dichotomized using ‘fairly often’ as the cutoff point for a negative impact. Multiple logistic regression models were fitted to define which descriptors of GR were associated with the dichotomous outcome of OHIP‐14, including dentine hypersensitivity in separate models, adjusting for age, gender, socioeconomic status, smoking, dental care, and missing teeth.

Results

Mean OHIP was significantly higher for individuals with ≥1 tooth with GR ≥2, ≥3, ≥4, and ≥5 mm. Individuals with ≥1 tooth with GR ≥2 mm had approximately two times higher chance of having a negative impact than individuals without GR of this threshold [odds ratio (OR) = 1.99, 95% confidence interval (CI) 1.05–3.78]. When buccal and proximal sites were analyzed separately, the presence of GR was significantly associated with worst quality of life only in anterior and not in posterior teeth. GR in the lower arch had no impact on OHRQoL. GR ≥2 mm affected only physical pain (OR = 2.61; 95% CI 1.06–6.42), whereas GR ≥4 mm affected functional limitation, physical pain, psychological discomfort, physical and psychological disabilities, with ORs ranging from 1.43 to 1.91. Dentine hypersensitivity alone was not associated with OHRQoL, but it modified the association between GR and OHIP when present concomitantly with GR, mainly in buccal sites.

Conclusions

OHRQoL is poorer in this adult population in the presence of GR, mainly in upper and anterior teeth. Dentine hypersensitivity and esthetics were found to be factors linking GR to OHRQoL.
Unmasking alpha diversity, cladogenesis and biogeographical patterning in an ancient panarthropod lineage (Onychophora: Peripatopsidae: Opisthopatus cinctipes) with the description of five novel species
Authors: Daniels Savel R. , Dambire Charlene , Klaus Sebastian , Sharma Prashant P.
Published: March 2016

Speciation and biogeographical patterning in the velvet worm Opisthopatus cinctipes was examined under a null hypothesis that numerous discrete lineages are nested within the species. A total of 184 O. cinctipes specimens, together with a single specimen of each of the two congeneric point endemic sister species (O. roseus and O. herbertorum), were collected throughout the forest archipelago in the Eastern Cape, KwaZulu‐Natal and Mpumalanga provinces of South Africa. All specimens were sequenced for two partial mitochondrial DNA loci (COI and 12S rRNA), while a single specimen from each locality was sequenced for the nuclear 18S rRNA locus. Evolutionary relationships were assessed using maximum‐likelihood and Bayesian inferences, while divergence time estimations were conducted using BEAST. A Bayesian species delimitation approach was undertaken to explore the number of possible novel lineages nested within Opisthopatus, while population genetic structure was examined for the COI locus using ARLEQUIN. Phylogenetic results revealed that O. cinctipes is a species complex comprising seven geographically discrete and statistically well‐supported clades. An independent statistical approach to species delimitations circumscribed ca. 67 species. Results from divergence time estimation and rate constancy tests revealed near constant net diversification occurring throughout the Eocene and Oligocene with subdivision of ranges during the Miocene. Gross morphological characters such as leg pair number within O. cinctipes were invariant, while dorsal and ventral integument colour was highly polymorphic. However, scanning electron microscopy revealed considerable differences both between and within clades. The caveats associated with both morphological and algorithmic delineation of species boundaries are discussed. The five novel Opisthopatus species are described.
JOB REALLOCATION, FINANCIAL CRISES, AND POLICY REFORMS: EVIDENCE FROM KOREA
Authors: Hyun Junghwan
Published: March 2016

This article investigates the dynamic process of job reallocation across Korean firms from 1985 to 2013 focusing on how the 1997 Korean financial crisis and the subsequent reforms altered job flows. I find evidence that while job reallocation was moderate and acyclical before the crisis, after the crisis it substantially intensified and exhibited procyclicality. Particularly, the reshuffling of employment across firms from different industries and of different sizes significantly occurred during the crisis period. Examining job reallocation from a geographical perspective, I find that the driving forces of regional job reallocation rates depend on the local heterogeneity of industries and geography. (JEL J63, E32, R10)
Eruptive angiokeratomas and porokeratosis in the setting of sclerodermatous graft‐vs.‐host disease
Authors: Marks Etan , Dorokhova Olena , Amin Bijal , Jacobson Mark
Published: March 2016

Porokeratosis and angiokeratomas are both seen in the setting of chronic graft‐vs.‐host disease (GVHD), but rarely occur together. We present a case of a patient with lichen planus‐like (LPL) and sclerodermatous chronic GVHD manifesting after allogeneic bone marrow transplant with concomitant eruptive angiokeratomas and porokeratosis.
Spindle B‐cell lymphoma: a rare variant of follicle center lymphoma
Authors: Elwan Nagwa M. , Abdel Salam Shady , Radwan Nesrin S.
Published: March 2016

Primary cutaneous follicle center lymphoma (PCFCL) is a common subtype of primary cutaneous B‐cell lymphoma (PCBCL). The prognosis of this subtype is favorable and recurrence is observed in up to 50% of patients. The dissemination to lymph nodes or internal organs is rare. In this study, two cases of rare variant of PCFCL are reported. Both cases presented with multiple erythematous nodules, plaques and some annular configurations. Histopathological examination revealed dermal lymphocytic infiltrates consisting of admixed centrocytes and centroblasts. Interestingly, spindle‐shaped cells with elongated nuclei, dispersed chromatin and scant cytoplasm were also detected. Immunohistochemical analysis revealed that all cells including the spindle cells were positive for CD20 and negative for CD3, CD43, CD10, CD34, CD68 and CD138. They were also negative for desmin and S‐100. They consistently expressed nuclear bcl‐6, but did not express bcl‐2. The histopathological and immunohistochemical examination suggest a rare case of primary cutaneous spindle cell B‐cell lymphoma (PCSBCL). Although few data is published about this rare subtype, PCSBCL is recently considered as a rare subtype of PCFCL. The prognosis and the nature of this peculiar subtype are not yet cleared. This indicates a great need for more investigations.
Pigmented desmoplastic trichilemmoma
Authors: Martínez‐Ciarpaglini Carolina , Monteagudo Carlos
Published: March 2016

Desmoplastic trichilemmoma (DT), the pseudomalignant variant of conventional trichilemmoma described by Hunt et al in 1990, displays a superficial lobular growth pattern of glycogen‐rich cells with peripheral nuclear palisading surrounded by a thickened basement membrane. DT differs from its conventional counterpart by showing a central hyalinized area with epithelial cords and strands mimicking invasive carcinoma. We report a case that fully satisfies the criteria for DT and, in addition, shows an extensive melanocytic cell component and prominent melanin deposition. To our knowledge, a pigmented variant of DT has not been reported and should be recognized in order to appropriately face the differential diagnosis with malignant pigmented tumors particularly pigmented basal cell carcinoma (BCC).
Clear cell atypical fibroxanthoma: a case report and review of the literature
Authors: Nguyen Catherine M. , Chong Kim , Cassarino David
Published: March 2016

Atypical fibroxanthoma (AFX) is a group of cutaneous tumors characterized by a population of fusiform, epithelioid and pleomorphic cells. Clinically, AFX is commonly found on the head and neck of older adults as a solitary ulcerated nodule. Clear cell atypical fibroxanthoma is a very rare variant of AFX, with only 13 cases reported to date. The differential diagnoses often include dermal neoplasms composed of clear cells, such as squamous cell carcinoma, basal cell carcinoma, metastatic renal cell carcinoma and balloon cell malignant melanoma. These diagnoses can be ruled out by the typical immunohistochemical profile of clear cell AFX, which is negative for specific epithelial and melanocytic markers. Herein, we describe a rare and unusual case of clear cell AFX arising on the ear of a relatively young adult patient. Histologically, the dermis was completely replaced by an atypical population of vacuolated cells with numerous atypical mitoses. Immunohistochemical stains were negative forpancytokeratin, CK5/6, CK7, and p63 S100 and Melan‐A stains. CD10 and CD68 stains were positive, making the findings consistent with the diagnosis of clear cell atypical fibroxanthoma.
Histopathologic diagnosis of multifactorial alopecia
Authors: Wohltmann Wendi E. , Sperling Leonard
Published: March 2016

Establishing a definitive diagnosis for any form of alopecia can be challenging. Adding to the diagnostic complexity is the fact that many patients have more than one form of alopecia contributing to their hair loss. We conducted a review of 1360 consecutive scalp biopsy specimens submitted for the evaluation of scalp hair loss over a 16‐month period, demonstrating that 12.5% of cases had a combination of diagnoses (multifactorial alopecia) accounting for their hair loss. An approach to the histopathologic diagnosis of multifactorial alopecia, particularly multiple forms of alopecia found in a single biopsy, is here presented.
Revisiting histopathologic findings in Goltz syndrome
Authors: Ko Christine J. , Antaya Richard J. , Zubek Amanda , Craiglow Brittany , Damsky William , Galan Anjela , McNiff Jennifer M.
Published: March 2016

Goltz syndrome (focal dermal hypoplasia) is an X‐linked dominant disorder that is classically associated with yellowish papules representing fat herniation (superficial adipocytes). We report a series of three cases, with clinicopathologic correlation of biopsies from Blaschkoid streaks. A range of histopathologic features, including some underreported findings (increased papillary dermal blood vessels, decreased thickness of the dermis, and adipocytes high in the dermis), are reproducible and can strongly point to the correct diagnosis of Goltz syndrome.
Canker disease of willow and poplar caused by Cryptosphaeria pullmanensis recorded in China
Authors: Ma R. , Zhu Y.‐F. , Fan X.‐L. , Tian C.‐M.
Published: March 2016

A new canker disease of Salix alba and Populus alba has been observed in Xinjiang, China. Black circular spots on dead branches and stems are the symptoms of the disease. Sixty‐seven isolates recovered from Salix matsudana, S. alba and Populus alba were identified as Cryptosphaeria pullmanensis based on morphological features and multigene phylogeny. Pathogenicity tests were performed on S. alba and P. alba stems using the C. pullmanensis isolates. Cankers on and Cryptosphaeria pullmanensis of C. pullmanensis from the stems fulfilled Koch's postulates and confirmed C. pullmanensis as the causal agent of the canker disease. C. pullmanensis is characterized by its yellow stromatic tissue surrounded by a black conceptacle with regularly arranged multiple locules sharing common walls and hyaline, allantoid, aseptate conidia (mean size 7.42 × 1.72 μm). This is the first report of C. pullmanensis causing Cryptosphaeria canker in China, and S. alba and P. alba are new host records for C. pullmanensis.
Evolution of drug‐tolerant nematode populations in response to density reduction
Authors: Reynolds Alan , Lindström Jan , Johnson Paul C. D. , Mable Barbara K.
Published: March 2016

Resistance to xenobiotics remains a pressing issue in parasite treatment and global agriculture. Multiple factors may affect the evolution of resistance, including interactions between life‐history traits and the strength of selection imposed by different drug doses. We experimentally created replicate selection lines of free‐living Caenorhabditis remanei exposed to Ivermectin at high and low doses to assess whether survivorship of lines selected in drug‐treated environments increased, and if this varied with dose. Additionally, we maintained lines where mortality was imposed randomly to control for differences in density between drug treatments and to distinguish between the evolutionary consequences of drug‐treatment versus ecological processes due to changes in density‐dependent feedback. After 10 generations, we exposed all of the selected lines to high‐dose, low‐dose and drug‐free environments to evaluate evolutionary changes in survivorship as well as any costs to adaptation. Both adult and juvenile survival were measured to explore relationships between life‐history stage, selection regime and survival. Intriguingly, both drug‐selected and random‐mortality lines showed an increase in survivorship when challenged with Ivermectin; the magnitude of this increase varied with the intensity of selection and life‐history stage. Our results suggest that interactions between density‐dependent processes and life history may mediate evolved changes in susceptibility to control measures.
Alternative method to facilitate resolution of paraphimosis after penile trauma in the horse
Authors: De Brouwer E. , Ribera T. , Climent F. , Prades M.
Published: March 2016

Inflammation associated with traumatic injury to the penis is characterised by pain, heat and oedema. Ensuing penile swelling interferes with retraction of the penis into the prepuce, resulting in paraphimosis. This report describes the use of a 5 l capacity pressure infusion bag to reduce penile oedema in three horses. This technique provided complete resolution of oedema and associated paraphimosis in approximately 1 h. The use of the bag, along with an abdominoinguinal bandage, a plastic funnel suspensory device, or a penile repulsion device (Probang) to avoid recurrence, offers a novel treatment that may be performed with the horse sedated.
Racecourse fracture management. Part 3: Emergency care of specific fractures
Authors: Wright I. M.
Published: March 2016

In consideration of first aid of appendicular fractures in the horse, the literature is inconsistent and in some cases wrong or misleading. This in large part is due to misunderstanding of fracture mechanics and this paper aims to give a contemporary review of the subject. It is particularly relevant for fractures that occur on the racecourse or in horses in training which, due to their aetiopathogenesis, have substantial site and configuration commonality. However, the techniques discussed are frequently also applicable to non‐racing injuries. Clinical features are important in assessing horses on the racecourse when imaging techniques are limited. This paper highlights these in order to guide decision making.
Unpacking the mechanisms captured by a correlative species distribution model to improve predictions of climate refugia
Authors: Briscoe Natalie J. , Kearney Michael R. , Taylor Chris A. , Wintle Brendan A.
Published: March 2016

Climate refugia are regions that animals can retreat to, persist in and potentially then expand from under changing environmental conditions. Most forecasts of climate change refugia for species are based on correlative species distribution models (SDMs) using long‐term climate averages, projected to future climate scenarios. Limitations of such methods include the need to extrapolate into novel environments and uncertainty regarding the extent to which proximate variables included in the model capture processes driving distribution limits (and thus can be assumed to provide reliable predictions under new conditions). These limitations are well documented; however, their impact on the quality of climate refugia predictions is difficult to quantify. Here, we develop a detailed bioenergetics model for the koala. It indicates that range limits are driven by heat‐induced water stress, with the timing of rainfall and heat waves limiting the koala in the warmer parts of its range. We compare refugia predictions from the bioenergetics model with predictions from a suite of competing correlative SDMs under a range of future climate scenarios. SDMs were fitted using combinations of long‐term climate and weather extremes variables, to test how well each set of predictions captures the knowledge embedded in the bioenergetics model. Correlative models produced broadly similar predictions to the bioenergetics model across much of the species' current range – with SDMs that included weather extremes showing highest congruence. However, predictions in some regions diverged significantly when projecting to future climates due to the breakdown in correlation between climate variables. We provide unique insight into the mechanisms driving koala distribution and illustrate the importance of subtle relationships between the timing of weather events, particularly rain relative to hot‐spells, in driving species–climate relationships and distributions. By unpacking the mechanisms captured by correlative SDMs, we can increase our certainty in forecasts of climate change impacts on species.
A Bi‐objective Optimization Model for Designing Safe Walking Routes for School Children
Authors: Tanaka Ken‐ichi , Miyashiro Ryuhei , Miyamoto Yuichiro
Published: March 2016

This study uses a mathematical optimization approach to design safe walking routes from school to home for children. Children are thought to be safer when walking together in groups rather than alone. Thus, we assume that the risk of walking along a given road segment in a group is smaller than that of walking the same segment alone. At the same time, the walking route between school and home for each child should not deviate substantially from the shortest route. We propose a bi‐objective model that minimizes both the total risk (particularly, the total distance walked alone) and the total walking distance for all children. We present an integer programming formulation of the proposed problem and apply this formulation to two instances based on actual road networks. We obtain Pareto optimal solutions using a mathematical programming solver and analyze the characteristics of the solutions and their potential applicability to real situations. The results show that the proposed model produces much better solutions compared with the solution where each child walks along the shortest path from school to home. In some optimal solutions, only a small deviation from the shortest path results in a dramatic reduction of the risk objective.
Maternal obesity, gestational diabetes, breastfeeding and childhood overweight at age 2 years
Authors: Bider‐Canfield Z. , Martinez M. P. , Wang X. , Yu W. , Bautista M. P. , Brookey J. , Page K. A. , Buchanan T. A. , Xiang A. H.
Published: March 2016

Background

Maternal obesity, excessive gestational weight gain (EGWG), gestational diabetes mellitus (GDM) and breastfeeding are four important factors associated with childhood obesity.

Objectives

The objective of the study was to assess the interplay among these four factors and their independent contributions to childhood overweight in a cohort with standard clinical care.

Methods

The cohort included 15 710 mother–offspring pairs delivered in 2011. Logistic regression was used to assess associations between maternal exposures and childhood overweight (body mass index >85th percentile) at age 2 years.

Results

Mothers with pre‐pregnancy obesity or overweight were more likely to have EGWG, GDM and less likely to breastfeed ≥6 months. Mothers with GDM had 40–49% lower EGWG rates and similar breastfeeding rates compared with mothers without GDM. Analysis adjusted for exposures and covariates revealed an adjusted odds ratio (95% confidence interval) associated with childhood overweight at age 2 years of 2.34 (2.09–2.62), 1.50 (1.34–1.68), 1.23 (1.12–1.35), 0.95 (0.83–1.10) and 0.76 (0.69–0.83) for maternal obesity, overweight, EGWG, GDM and breastfeeding ≥6 months vs. <6 months, respectively.

Conclusions

In this large clinical cohort, GDM was not associated with, but maternal pre‐pregnancy obesity or overweight and EGWG were independently associated with an increased risk, and breastfeeding ≥6 months was associated with a decreased risk of childhood overweight at age 2 years.
Nature of Interatomic Bonding in Controlling the Mechanical Properties of Calcium Silicate Hydrates
Authors: Dharmawardhana Chamila , Bakare Morayo , Misra Anil , Ching Wai‐Yim
Published: March 2016

Calcium silicate hydrate (C–S–H) is the most important phase of hydrated cement gel which is the key material in construction industry. It is well accepted that hardened cement paste consists of either poorly crystalline or completely disordered phases. Although a myriad of speculative atomistic models of disordered C–S–H have been proposed, the fundamental basis of structure–property relationships remain elusive. This study focuses upon the correlations between mechanical properties and electronic structure based on well‐defined quantum mechanical parameters. We use 20 CSH minerals with known structure to gain fundamental understanding of structure–property relationship. The results indicate Si–O bond order density, which represents the cumulative bond strength of SiO bonds, has no direct correlation with bulk mechanical properties which is counterintuitive and against conventional wisdom. The variations are determined more precisely by the overall atomic and electronic structure dictated by bond order density of the Ca–O and hydrogen bonds (HB). Most importantly, there is a multifaceted balance between different types of interatomic bonds including the HBs in controlling mechanical properties. HBs categorized in relation to next nearest neighbor (NNN) enable us to identify specific types of HBs that are prevalent in CSH. In certain crystals such as suolunite, the HB network is organized in such a unique way that enhances its mechanical properties. The approach and findings presented in this paper points to a broad roadmap for the developing next‐generation cements.
Old and Unemployable? How Age‐Based Stereotypes Affect Willingness to Hire Job Candidates
Authors: Abrams Dominic , Swift Hannah J. , Drury Lisbeth
Published: March 2016

Across the world, people are required, or want, to work until an increasingly old age. But how might prospective employers view job applicants who have skills and qualities that they associate with older adults? This article draws on social role theory, age stereotypes and research on hiring biases, and reports three studies using age‐diverse North American participants. These studies reveal that: (1) positive older age stereotype characteristics are viewed less favorably as criteria for job hire, (2) even when the job role is low‐status, a younger stereotype profile tends to be preferred, and (3) an older stereotype profile is only considered hirable when the role is explicitly cast as subordinate to that of a candidate with a younger age profile. Implications for age‐positive selection procedures and ways to reduce the impact of implicit age biases are discussed.
Resource Scarcity and Prescriptive Attitudes Generate Subtle, Intergenerational Older‐Worker Exclusion
Authors: North Michael S. , Fiske Susan T.
Published: March 2016

Prior work describes specific, prescriptive resource tensions between generations, comprising active Succession, passive Consumption, and symbolic Identity (SCI; North and Fiske). The current paper focuses on how these domains potentially drive intergenerational exclusion in work‐related networking and training spheres. Studies 1a–c—each focusing on a different SCI domain—manipulated perceived resource availability between generations, then introduced a professional networking opportunity. Across studies, scarcity reduced the likelihood of young participants’ networking engagement with older workers who violated SCI resource expectations. Study 2 impelled participants to allocate scarce training resources among three similarly qualified but different‐aged employees (younger, middle‐aged, and older). Older workers received the lowest such investment, particularly among younger participants—an effect driven by Succession beliefs, per mediation analyses. Overall, the findings emphasize resource tensions in driving older workers’ subtle exclusion by younger generations; minimizing such tensions will be critical for aging, increasingly intergenerational workplaces.
Why and When Do Learning Goal Orientation and Attitude Decrease with Aging? The Role of Perceived Remaining Time and Work Centrality
Authors: Kooij Dorien T.A.M. , Zacher Hannes
Published: March 2016

We conducted two studies to improve our understanding of why and when older workers are focused on learning. Based on socioemotional selectivity theory, which proposes that goal focus changes with age and the perception of time, we hypothesized and found that older workers perceive their remaining time at work as more limited than younger workers which, in turn, is associated with lower learning goal orientation and a less positive attitude toward learning and development. Furthermore, we hypothesized and found that high work centrality buffers the negative association between age and perceived remaining time, and thus the indirect negative effects of age on learning goal orientation and attitude toward learning and development (through perceived remaining time). These findings suggest that scholars and practitioners should take workers’ perceived remaining time and work centrality into account when examining or stimulating learning activities among aging workers.
Development of a TaqMan Real‐Time Polymerase Chain Reaction Assay for Detection and Quantification of Fusarium oxysporum f. sp. lycopersici in Soil
Authors: Huang Cheng‐Hua , Tsai Rong‐Tzong , Vallad Gary E.
Published: March 2016

Fusarium wilt, caused by Fusarium oxysporum f. sp. lycopersici (FOL), is an important disease of tomato. Pathogenicity and vegetative compatibility tests, although reliable, are laborious for the identification of FOL isolates and cannot efficiently quantify population densities of FOL in the soil. The objective of this study was to develop a rapid, sensitive and quantitative real‐time polymerase chain reaction (PCR) assay for detecting and quantifying FOL in soil. An inexpensive and relatively simple method for soil DNA extraction and purification was developed based on bead‐beating and a silica‐based DNA‐binding method. A TaqMan probe and PCR primers were designed using the DNA sequence of the species‐specific virulence gene SIX1, which is only present in isolates of FOL, not in isolates of other formae speciales or non‐pathogenic isolates of F. oxysporum. The real‐time PCR assay successfully amplified isolates of three races of FOL used in this study and quantified FOL DNA in soils, with a detection limit of 0.44 pg of genomic DNA of FOL in 20 μl of the real‐time PCR. A spiking test performed by adding different concentrations of conidia to soil showed a significant linear relationship between the amount of genomic DNA of FOL detected by the real‐time PCR assay and the concentration of conidia added. In addition, the real‐time PCR assay revealed a significant quadratic regression for a glasshouse experiment between disease severity and DNA concentration of FOL. The soil DNA extraction method and real‐time PCR assay developed in this study could be used to determine population densities of FOL in soil, develop threshold models to predict Fusarium wilt severity, identify high‐risk fields and measure the impact of cultural practices on FOL populations in soils.
A Strobilurin Fungicide Relieves Bipolaris oryzae‐Induced Oxidative Stress in Rice
Authors: Debona Daniel , Rodrigues Fabrício A.
Published: March 2016

Although strobilurins are one of the most effective and broad spectrum classes of systemic fungicides, they may also increase plant stress tolerance by modulating the activity of antioxidant enzymes. To address this issue, the effect of azoxystrobin (Az) on the activity of antioxidant enzymes and on the concentrations of antioxidant metabolites and oxidative stress‐related compounds was studied in rice plants (cv. Metica‐1) either inoculated or not with Bipolaris oryzae, the causal agent of brown spot (BS). The Az minimally affected the enzyme activities, but consistently increased the glutathione reduced (GSH) concentrations in the noninoculated plants. The activities of superoxide dismutase, peroxidase, ascorbate peroxidase, glutathione peroxidase, glutathione reductase and glutathione‐S‐transferase were increased upon B. oryzae infection, but such increases were greatly limited in the Az‐sprayed plants. Catalase activity decreased in the inoculated plants compared to the noninoculated plants regardless of fungicide treatment. The GSH concentration increased in response to the B. oryzae infection, and the Az‐sprayed plants sustained higher levels of GSH at advanced stages of fungal infection than did the nonsprayed plants. The inoculated plants exhibited an extensive oxidative stress as evidenced by higher concentrations of hydrogen peroxide and malondialdehyde compared to the noninoculated plants, but lower and later increases were recorded in the Az‐sprayed plants than in the nonsprayed plants. Therefore, Az greatly reduces B. oryzae‐induced oxidative stress by limiting BS development rather than by activating antioxidant enzymes. The GSH, however, seems to be Az‐modulated, and this may partially explain the constrained oxidative stress observed in the Az‐sprayed plants.
Estimating spatially specific demand and supply of dental services: a longitudinal comparison in Northern Germany
Authors: Schwendicke Falk , Jäger Ralf , Hoffmann Wolfgang , Jordan Rainer A. , van den Berg Neeltje
Published: March 2016

Objectives

Assessing the spatial distribution of oral morbidity‐related demand and the workforce‐related supply is relevant for planning dental services. We aimed to establish and validate a model for estimating the spatially specific demand and supply. This model was then applied to compare demand‐supply ratios in 2001 and 2011 in the federal state of Mecklenburg–Vorpommern (Northern Germany).

Methods

The spatial units were zip code areas. Demand per area was estimated by linking population‐specific oral morbidities to working times via insurance claim data. Estimated demand was validated against the provided demand in 2001 and 2011. Supply was calculated for both years using cohort data from the dentist register. The ratio of demand and supply was geographically mapped and its distribution between areas assessed using the Gini coefficient.

Results

Between 2001 and 2011, a significant decrease of the general population (−7.0 percent), the annual demand (−13.1 percent), and the annual supply (−12.9 percent) was recorded. The estimated demands were nearly (2001: −4 percent) and completely (2011: ±0 percent) congruent with provided demands. The average demand‐supply‐ratio did not change significantly between 2001 and 2011 (P > 0.05), but was increasingly unequally distributed. In both years, few areas were over‐serviced, while many were under‐serviced.

Conclusions

The established model can be used to estimate spatially specific demand and supply.
The histopathological comparison on the destruction of the periodontal tissue between normal junctional epithelium and long junctional epithelium
Authors: Noguchi S. , Ukai T. , Kuramoto A. , Yoshinaga Y. , Nakamura H. , Takamori Y. , Yamashita Y. , Hara Y.
Published: March 2016

Background and Objective

The barrier function of long junctional epithelium is thought to be important after periodontal initial therapy and periodontal surgery. Although the difference between long junctional epithelium and normal junctional epithelium regarding their resistance to destruction of periodontal tissue has been investigated, the mechanism still remains unclear. Using our rat experimental periodontitis model in which loss of attachment and resorption of alveolar bone is induced by the formation of immune complexes, we investigated the resistance of periodontal tissue containing long junctional epithelium and normal junctional epithelium to destruction.

Material and Methods

Rats were divided into four groups. In the immunized long junctional epithelium (I‐LJE) group, rats were immunized with lipopolysaccharide (LPS), and curettage and root planing procedures were performed on the palatal gingiva of the maxillary first molars to obtain reattachment by long junctional epithelium. In the immunized normal junctional epithelium (I‐JE) group, rats were immunized without curettage and root planing procedures. In the nonimmunized long junctional epithelium (nI‐LJE) group, rats were not immunized but curettage and root‐planing procedures were performed. In the control group, neither immunization nor curettage and root‐planing was performed. In all rats, periodontal inflammation was induced by topical application of LPS into the palatal gingival sulcus of maxillary first molars. The rats were killed at baseline and after the third and fifth applications of LPS. Attachment loss and the number of inflammatory cells and osteoclasts in the four groups were compared histopathologically and histometrically.

Results

After the third application of LPS in the I‐LJE group, attachment loss showed a greater increase than in control and nI‐LJE groups, and inflammatory cell infiltration and osteoclasts were increased more than in the other groups. After the fifth application of LPS, attachment loss was greater and there was a higher degree of inflammatory cell infiltration in nI‐LJE and I‐LJE groups than in control and I‐JE groups.

Conclusion

Our findings suggest that the destruction of periodontal tissue is increased in tissue containing long junctional epithelium compared with normal junctional epithelium and that the immunized condition accelerates the destruction by forming immune complexes.
Testing for Change‐Points in Long‐Range Dependent Time Series by Means of a Self‐Normalized Wilcoxon Test
Authors: Betken Annika
Published: March 2016

We propose a testing procedure based on the Wilcoxon two‐sample test statistic in order to test for change‐points in the mean of long‐range dependent data. We show that the corresponding self‐normalized test statistic converges in distribution to a non‐degenerate limit under the hypothesis that no change occurred and that it diverges to infinity under the alternative of a change‐point with constant height. Furthermore, we derive the asymptotic distribution of the self‐normalized Wilcoxon test statistic under local alternatives, that is, under the assumption that the height of the level shift decreases as the sample size increases. Regarding the finite sample performance, simulation results confirm that the self‐normalized Wilcoxon test yields a consistent discrimination between hypothesis and alternative and that its empirical size is already close to the significance level for moderate sample sizes.
Exploring the Links Between Texture Perception and Bolus Properties Throughout oral Processing. Part 1: Breakdown Paths
Authors: Young Ashley K. , Cheong Jean Ne , Foster Kylie D. , Hedderley Duncan I. , Morgenstern Marco P. , James Bryony J.
Published: March 2016

This study explored links between texture perception and breakdown path throughout oral processing. Five subjects chewed a short dough biscuit recipe. Dynamic textural perception was followed using Temporal Dominance of Sensations. Subjects expectorated at three stages of bolus formation (early, mid, and point of swallow). Visual inspection and moisture content (MC) provided a description of breakdown path. Interindividual differences in perceived texture and breakdown paths were observed. This study indicated differences between how individuals used sensory texture terms to describe bolus structure. The dry‐to‐sticky dominance transition corresponded to increased mixing and MC. However, there was not a significant change in MC for all subjects.A panel‐level analysis agreed with the “Mouth Process” model but there were interindividual differences at the point of swallow. This study suggests that there may not be a universal swallowing threshold for this biscuit recipe in terms of the measured properties but does indicate it may be possible to group consumers using bolus structure swallowing thresholds.

Practical Applications

Oral processing of a solid food involves food breakdown and reassembly with saliva into a deformable bolus that can be swallowed safely. The relationships between masticatory behavior, perceived texture, bolus structure, and mechanical and rheological properties throughout oral processing are still not fully understood. This study provides evidence of the subjective nature of oral processing and texture perception but indicates that each individual is not necessarily unique. Consumers may be able to be categorized into different groups based upon sensory dominance, bolus structure, and moisture content swallowing thresholds. Understanding these groupings could aid in the design of foods that follow a desired oral processing path and therefore provide consumers with a specific sensory experience.
Exploring the Links Between Texture Perception and Bolus Properties Throughout Oral Processing. Part 2: Bolus Mechanical and Rheological Properties
Authors: Young Ashley K. , Cheong Jean Ne , Foster Kylie D. , Hedderley Duncan I. , Morgenstern Marco P. , James Bryony J.
Published: March 2016

This study explored links between texture perception, breakdown path, and bolus properties throughout oral processing. Five subjects chewed biscuits to three stages of bolus formation (early, mid, and point of swallow). Bolus properties were measured using back extrusion (BE) (yield stress) and a modified texture profile analysis, consecutive double compression (CDC) (peak force, “adhesiveness”, and “cohesiveness”). The validity of the testing methods was discussed and BE was found to be better suited than CDC for testing boluses of varying size. In addition, results indicated that a greater understanding of the properties being measured by the CDC parameters is required. The bolus properties were linked to texture perception and breakdown path results presented in Part 1 of this study.

At a panel‐level, yield stress and peak force decreased and “adhesiveness” and “cohesiveness” increased throughout oral processing. Interindividual differences were found in bolus mass, yield stress, peak force, “adhesiveness”, “cohesiveness”, and description of bolus properties using texture terms. A panel‐level analysis agreed with the “Mouth Process” and “Optimum Swallow” models. However, not all individuals' results were consistent with the latter model. A universal swallowing threshold for this biscuit recipe in terms of the measured properties was not found. Results suggest consumers can potentially be grouped by sensory experience, breakdown path, or bolus properties.

Practical Applications

The relationships between masticatory behavior, perceived texture, bolus structure, and mechanical and rheological properties throughout oral processing are still not fully understood. This study applies modified texture profile analysis and back extrusion methods for the testing of boluses at different stages of oral processing and discusses their validity. This study indicates that analyzing texture‐bolus property relationships at a panel – rather than individual – level may not provide a full picture of consumer experience. Although there are differences between consumers, they can potentially be grouped by sensory experience, food breakdown path, or bolus properties (including bolus moisture content and rheology). These groupings could be used to design studies that are more applicable to a general population and may be useful in tailoring foods to specific target groups.
GS‐9857 in patients with chronic hepatitis C virus genotype 1–4 infection: a randomized, double‐blind, dose‐ranging phase 1 study
Authors: Rodriguez‐Torres M. , Glass S. , Hill J. , Freilich B. , Hassman D. , Di Bisceglie A. M. , Taylor J. G. , Kirby B. J. , Dvory‐Sobol H. , Yang J. C. , An D. , Stamm L. M. , Brainard D. M. , Kim S. , Krefetz D. , Smith W. , Marbury T. , Lawitz E.
Published: March 2016

GS‐9857, an inhibitor of the hepatitis C virus (HCV) nonstructural protein (NS) 3/4A, demonstrates potent activity against HCV genotypes 1–6 and improved coverage against commonly encountered NS3 resistance‐associated variants (RAVs). In this study, the safety, tolerability, antiviral activity and pharmacokinetics (PK) of GS‐9857 were evaluated in patients with chronic HCV genotype 1–4 infection. Patients with genotype 1–4 infection received placebo or once‐daily GS‐9857 at doses ranging from 50 to 300 mg for 3 days under fasting conditions. GS‐9857 was well tolerated; all reported adverse events (AEs) were mild or moderate in severity. Diarrhoea and headache were the most commonly reported AEs. Grade 3 or 4 laboratory abnormalities were observed in 17% of patients receiving GS‐9857; there were no Grade 3 or 4 abnormalities in alanine aminotransferase, aspartate aminotransferase or alkaline phosphatase levels. GS‐9857 demonstrated potent antiviral activity in patients with chronic HCV infection, achieving mean and median maximum reductions in HCV RNA of ≥3 log10 IU/mL following administration of a 100‐mg dose in patients with HCV genotype 1a, 1b, 2, 3 or 4 infection. The antiviral activity of GS‐9857 was unaffected by the presence of pretreatment NS3 RAVs. In patients with genotype 1–4 infection, GS‐9857 exhibited linear PK and was associated with a median half‐life of 29–42 h, supporting once‐daily dosing. Thus, the tolerability, efficacy and pharmacokinetic profile of GS‐9857 support its further evaluation for treatment of patients with chronic HCV infection.
It's story time!: exploring the potential of multimodality in oral storytelling to support children's vocabulary learning
Authors: Lwin Soe Marlar
Published: March 2016

Although many studies have been done on the benefits of parent/teacher‐child interactions during shared storybook reading or read‐aloud sessions, very few have examined the potential of professional storytellers' oral discourse to support children's vocabulary learning. In those storytelling sessions conducted by professional storytellers, the process of telling a story is typically not accompanied by a book, but only by the teller's well‐coordinated gestures, facial expressions and voice modulations. In this study, I perform a multimodal analysis of storytellers' oral discourse recorded during two storytelling sessions for four‐to‐five‐year‐old children. The study aims to (1) find out the specific types of vocal and visual features accompanying the spoken words which were unlikely to be known by the children but used by the storytellers for representations of events and characters, and (2) explore the potential of these multimodal features in oral storytelling to support children's inferring of word meanings. The study offers insights into multimodality in oral storytelling and implications for exploring the potential of multimodal features in this form of literacy practice to support children's vocabulary learning.
Effect of obesity and weight loss on ventricular repolarization: a systematic review and meta‐analysis
Authors: Omran J. , Firwana B. , Koerber S. , Bostick B. , Alpert M. A.
Published: March 2016

We performed a systematic review and meta‐analysis of the effects of obesity ± overweight and weight loss on the corrected QT interval (QTc) and QT or QTc dispersion (indices of ventricular repolarization). Mean difference for both QTc and QT or QTc dispersion with 95% confidence intervals (CIs) was calculated comparing obese ± overweight subjects and normal weight controls and QTc and QT or QTc dispersion before and after weight loss from diet ± exercise or bariatric surgery. A total of 22 studies fulfilled the selection criteria. Compared with normal weight controls, there was a significantly longer QTc in obese ± overweight subjects (mean difference of 21.74 msec, 95% CI: 18.76 to 22.32) and significantly longer QT or QTc dispersion (mean difference of 15.17 msec, 95% CI: 13.59 to 16.74). Weight loss was associated with a significant decrease in QTc (mean difference −25.77 msec, 95% CI: −28.33–23.21) and QT or QTc dispersion (mean difference of −13.46 msec, 95% CI: −15.60 to −11.32 in obese ± overweight subjects. Thus, obesity ± overweight is associated with significant prolongation of QTc and QT or QTC dispersion. Weight loss in obese ± overweight subjects produces significant decreases in these variables. © 2016 World Obesity
Auditory functional magnetic resonance in awake (nonsedated) and propofol‐sedated children
Authors: Gemma Marco , Scola Elisa , Baldoli Cristina , Mucchetti Marta , Pontesilli Silvia , De Vitis Assunta , Falini Andrea , Beretta Luigi
Published: March 2016

Background

Functional Magnetic Resonance Imaging (fMRI) is often used in preoperative assessment before epilepsy surgery, tumor or cavernous malformation resection, or cochlear implantation. As it requires complete immobility, sedation is needed for uncooperative patients.

Objective

The aim of this study was to compare the fMRI cortical activation pattern after auditory stimuli in propofol‐sedated 5‐ to 8‐year‐old children with that of similarly aged nonsedated children.

Methods

When possible, children underwent MRI without sedation, otherwise it was induced with i.v. propofol 2 mg·kg−1 and maintained with i.v. propofol 4–5 mg·kg−1·h−1. Following diagnostic MRI, fMRi was carried out, randomly alternating two passive listening tasks (a fairy‐tale and nonsense syllables).

Results

We studied 14 awake and 15 sedated children. During the fairy‐tale task, the nonsedated children's blood‐oxygen‐level‐dependent (BOLD) signal was bilaterally present in the posterior superior temporal gyrus (STG), Wernicke's area, and Broca's area. Sedated children showed similar activation, with lesser extension to Wernicke's area, and no activation in Broca's area. During the syllable task, the nonsedated children's BOLD signal was bilaterally observed in the STG and Wernicke's area, in Broca's area with leftward asymmetry, and in the premotor area. In sedated children, cortical activation was present in the STG, but not in the frontal lobes. BOLD signal change areas in sedated children were less extended than in nonsedated children during both the fairy‐tale and syllable tasks. Modeling the temporal derivative during both the fairy‐tale and syllable tasks, nonsedated children showed no response while sedated children did.

Conclusions

After auditory stimuli, propofol‐sedated 5‐ to 8‐year‐old children exhibit an fMRI cortical activation pattern which is different from that in similarly aged nonsedated children.
A good story: Men's storytelling ability affects their attractiveness and perceived status
Authors: DONAHUE JOHN K. , GREEN MELANIE C.
Published: March 2016

Three studies examined gender differences in the effect of storytelling ability on perceptions of a person's attractiveness as a short‐term and long‐term romantic partner. In Study 1, information about a potential partner's storytelling ability was provided. Study 2 participants read a good or poor story supposedly written by a potential partner. Results suggested that only women's attractiveness assessments of men as a long‐term date increased for good storytellers. Storytelling ability did not affect men's ratings of women nor did it affect ratings of short‐term partners. Study 3 suggested that the effect of storytelling ability on long‐term attractiveness for male targets may be mediated by perceived status. Storytelling ability appears to increase perceived status and thus helps men attract long‐term partners.