bluuebunny/crossref_metadata_2025 huggingface dataset:
Incidence and average cost per toxicity in patients treated with nivolumab.
Authors: Mason Neil Thomas , Khushalani Nikhil I. , Antonia Scott Joseph , McLeod Howard L.
Published: November 2019

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Background: Recently approved PD-1 inhibitors such as nivolumab have demonstrated clear efficacy in metastatic melanoma and other cancers, but also come at a high cost and with the potential for severe side effects. However, most of the data available comes from clinical trials rather than patients treated in clinical practice as standard-of-care. This study reports the incidence of severe toxicities in a number of cancer types and estimates the per patient cost of managing these toxicities. Methods: Patients with metastatic melanoma, non-small cell lung cancer, renal cell carcinoma, and Hodgkin’s lymphoma treated with nivolumab between January 1, 2014 through April 30, 2016 were identified at Moffitt Cancer Center (N=74). Toxicities occurring during treatment or within 2 months of stopping treatment were identified by a chart review and each toxicity graded using the CTCAE 4.0 criteria. A cost of care analysis was performed to estimate the cost of serious toxicities (Grade 3-5) compared to a control group who experienced no or minor adverse events (Grade 0-2). Billing data was used to estimate the mean cost of care for each group. Costs were subcategorized by service line, e.g., pharmacy costs, radiology, laboratory services. Results: The most common severe toxicities were anemia, dyspnea, renal failure, colitis, fatigue, and pneumonitis (Table 1). The average cost of care for patients experiencing grade 3-5 toxicities was $2,036 higher than those without toxicity. Conclusions: The incidence of toxicity in our population was similar to that reported in clinical trials. Costs were higher for patients with toxicities, driven by additional outpatient care (19% higher cost per patient) as well as additional pharmacy costs (22% higher per patient). Though small in comparison to the cost of nivolumab, over $6,000 per dose, these costs should not be dismissed, particularly when performing cost effectiveness and value research. [Table: see text]
Preliminary results from a single-arm, phase II study assessing the efficacy of pembrolizumab plus radiotherapy in metastatic triple negative breast cancer.
Authors: Ho Alice , Barker Christopher Andrew , Gucalp Ayca , Lebron-Zapata Lizza , Wen Yong Hannah , Phung Anh , Wilgucki Molly , Henrich Micaela , Arnold Brittany , Patil Sujata , McArthur Heather L.
Published: November 2019

95

Background: Two trials have demonstrated overall response rates of 19% with immune checkpoint inhibitors alone in chemotherapy-resistant triple negative breast cancer (TNBC). Radiation therapy (RT) is frequently used to enhance local control in TNBC and has been reported to induce distant (abscopal) tumor responses when combined with immunotherapy. We evaluate the safety and efficacy of the combination of RT and pembrolizumab, a programmed cell death protein 1 (PD-1) inhibitor, in a single-arm, two-stage, phase II study in metastatic TNBC. Results from the first stage are reported. Methods: Eligibility criteria includes women with biopsy-proven TNBC, ECOG performance status 0-2, ≥ 2 measurable sites of metastatic disease with at least one site requiring RT. A total RT dose of 3000 cGy is delivered in one week in 5 fractions. Pembrolizumab is given intravenously at 200 mg/kg D1+/- 3 days and then every 3 weeks until disease progression as defined by RECIST v 1.1. The primary endpoint is overall response rate at week 13 in the non-targeted, non-irradiated lesions. Secondary endpoints include safety and overall survival. Tumor biopsies are obtained at baseline and at week 7. PD-L1 expression was not required for study entry. Results: Nine patients were enrolled in the first phase and assessed for antitumor activity and safety. Median age was 52 years (range 37-73). Three patients died secondary to disease-related complications (at weeks 2, 6 and 8) and 1 came off study due to disease progression prior to week 13. Of the 5 patients evaluable at week 13, 2 had a partial response, 1 had stable disease and 2 had disease progression. Common toxicities were mild and included fatigue, myalgia and nausea. One grade 3 event was reported - hyperbilirubinemia not attributable to study therapy after one dose of pembrolizumab. Conclusions: The combination of pembrolizumab and RT was well-tolerated in the first stage of a phase II study. Responses were observed outside of the RT fields in 2 of 5 patients who were evaluable at 13 weeks. The contribution of RT to pembrolizumab is unknown and will be investigated in the second stage of the study, which is ongoing. Correlative studies are planned. Clinical trial information: NCT02730130.
Sample Timing, Diagnosis of Subclinical Thyroid Dysfunction and Mortality in Acute Myocardial Infarction: ThyrAMI1 Study
Authors: Razvi Salman , Leng Owain , Jabbar Avais , Bano Arjola , Ingoe Lorna , Addison Caroline , Thomas Honey , Carey Peter , Junejo Shahid , Austin David , Greenwood John P , Zaman Azfar
Published: November 2019

Objective

The objective of this study was to determine the impact of blood sample timing on the diagnosis of subclinical thyroid dysfunction (SCTD) and mortality in patients with acute myocardial infarction (AMI).

Patients, Design, and Main Outcome Measures

Patients with AMI had thyroid function evaluated on admission between December 2014 and December 2016 and those with abnormal serum thyrotropin (TSH) had repeat thyroid function assessed at least a week later. The association between sample timing and SCTD was evaluated by logistic regression analysis. Secondary outcomes were confirmation of SCTD on repeat testing and all-cause mortality up to June 2018.

Results

Of the 1806 patients [29.2% women, mean (± standard deviation) age of 64.2 (±12.1) years] analyzed, the prevalence of subclinical hypothyroidism (SCH) was 17.2% (n = 311) and subclinical hyperthyroidism (SHyper) was 1.2% (n = 22) using a uniform TSH reference interval. The risk of being diagnosed with SCTD varied by sample timing in fully-adjusted models. The risk of SCH was highest between 00.01 and 06.00 hours and lowest between 12.01 and 18.00 hours, P for trend <.001, and risk of SHyper was highest between 12.01 hours and 18.00 hours and lowest between 00.01 hours and 06.00 hours. Furthermore, time of the initial sample was associated with the risk of remaining in a SCH state subsequently. Mortality in SCH patients was not elevated when a uniform TSH reference interval was utilized. However, when time period–specific TSH reference ranges were utilized, the mortality risk was significantly higher in SCH patients with HR (95% CI) of 2.26 (1.01–5.19), P = .04.

Conclusions

Sample timing impacts on the diagnosis and prognosis of SCH in AMI patients. If sample timing is not accounted for, SCH is systemically misclassified, and its measurable influence on mortality is lost.
On Displacement
Authors: Klosterwill Kevan
Published: November 2019

Do urban open spaces, whether comprised of small planting beds and gardens or larger parks and reserves, signal the juxtaposition of two worlds, two forms of life, one human and one natural and nonhuman? Or are those spaces necessarily embedded within the logics of real estate capital that shape cities? And if so, can this be avoided? This article explores the operation of three large-scale site-specific artworks in New York City that suggest other logics by which botanically dominated spaces might operate in the city: a recent work by Mary Mattingly entitled Swale, as well as two more well-known works, Alan Sonfist’s Time Landscape and Agnes Denes’s Wheatfield—A Confrontation. These works share similar form, scale, and media but most significantly function as social practice artworks that enact multispecies performances. Drawing on notions of urban cosmopolitics, the article considers how these works illustrate and perform alternative worlds and forms of life in an environment that is perceived as hostile to those ways of being. These works resist a totalizing impulse in the production of urban architectures and landscapes that would prematurely foreclose the world to nonhuman agency through a project of human control of all environmental variables. Theories of heterotopias as counter-spaces facilitate exploration of “displacement” as a metaphor that accounts for both the attempted eviction of alternative environmental practices and the works’ ongoing strategies of resistance. Through tactics such as orderly frames, sustained interactions, and cleverly attenuated performative practices, these works resist co-option within capitalist logics, which would prematurely close off the worlds they call into being. My discussion of these art-activist efforts brings authors on multispecies relations into conversation with landscape and urban theorists, raising possibilities for more-than-human modes of understanding urban and environmental design practice, with these activist artworks providing inspiration for and interpretation of alternative urban spatial practices.
Extractive Fictions and Postextraction Futurisms
Authors: Henry Matthew S.
Published: November 2019

This essay operates at the intersection of the energy humanities and environmental justice studies to survey extractive fictions, a term I use to describe literature and other cultural forms that render visible the socioecological impacts of extractive capitalism and problematize extraction as a cultural practice. The essay first theorizes extraction and examines cultural representations of coal and gas fields in northern Appalachia, including Ann Pancake’s novel Strange as This Weather Has Been (2007) and Jennifer Haigh’s novel Heat and Light (2015). Each, by rendering visible instances of environmental degradation and economic decline associated with energy development, challenges the deep-seated role of extraction as a cornerstone of regional cultural identity and the mythos of fossil fuel development as a path to economic and social progress. In doing so, they lay bare the epistemological failures of extractive capitalism, a mode of accumulation based on the large-scale withdrawal and processing of natural resources. The final section of the essay turns to the AMD&ART Park in Vintondale, Pennsylvania, and artist-activist John Sabraw’s toxic-art initiative in southern Ohio, both of which address these failures through the articulation of postextraction futurism, a critical method that combines environmental science and historically situated aesthetics to remediate ecological and social injustices associated with extraction. Both projects emerge from collaborations among artists, academics, scientists, and local communities to reverse the impacts of extraction through innovative water reclamation techniques and art exhibits that memorialize the region’s coal heritage. These initiatives complement extractive fictions to envision an inclusive, livable Appalachia unencumbered by the dictates of extractive capitalism.
The TransAlien Manifesto
Authors: Puig Krizia
Published: November 2019

This is not an article. If anything, these are “trans futurist spiritual science visions”: radically vulnerable interventions that aim to disrupt naturalized forms of publishable knowledge while centering the needs, fantasies, and longings of disabled queer/trans folks in practices of future-making. These lines transcend the limits of academic knowledge. They are an act of resistance against the logics of subjectivity, relationality, fulfillment, and temporality that permeate current and envisioned notions of love(s). Here, a game for us to play: a theoretical-performative experiment to envision future notions of relationality—while shifting the hypernormative and cis hetero-romantic logics behind contemporary understandings of what sex robots should do and/or be. This is an exploration of the challenges/potentialities of relationships “AmongWithToThrough” humans and nonhuman organic, virtual, and/or synthetic beings. For you—disjointed knowledge: I am jamming on the paper, and there is a soundtrack for each section. I spin the page, and invite you to read with(in) the music. Endnotes are important: engage with them. I do not offer settled conclusions. Above all, this is una ofrenda a corazón abierto written in pain (chronic pain) or maybe an invitation for you to hold my hand. Honor your bodymindspirit: read in any order and think whatever you want when you finish. Thank you very much for your time. All the love and light . . .
Cart No.1, Monoecious Fruits, the Harvest of 1519
Authors: Quezada Vick
Published: November 2019

The following works are an exploration of the histories of colonization that the Mestizo experience in North America as well as how the settler colonial phenomenon continues to exist in the contemporary United States. The projects scrutinize the impact of racism, transphobia, classism, capitalism, and heteropatriarchy, as they affect the material realities of people whose lives are determined by their relationship to Western ideology and the gender construct. The use of sculpture, photography, and craft within the bodies of work help conceptualize the tension of Indigenous and Western narratives. Vick Quezada seeks to reconcile and intervene in Western “commonsense” notions by merging material culture by way of abstraction. Quezada is most compelled by the places where evidence of resistance and survival is made manifest. Through their work they desire to generate alternative empathies that open paths for a new consciousness.
Calling Self-Indulgence
Authors: de Leon J
Published: November 2019

Recent works by trans and nonbinary poets, including Oliver Baez Bendorf, Jos Charles, jayy dodd, Joshua Jennifer Espinoza, Paige Lewis, and Danez Smith, gesture to a new mode of trans-confessional poetry. Trans poets practice naming as a form of self-indulgence, and trans names and pronouns are a form of poetry—following Audre Lorde's articulation—read into the world to give it new shape. In trans naming practices and poetry, self-indulgences are also demands made of another, a new name or unexpected pronoun asking for an affirmative repetition, a performative reflection: mirror restaging. Gender, like self-indulgence, is never accomplished alone. It relies on an audience that either affirms and repeats—or refuses—one's request to be seen and understood in a way that breaks from expectation. I closely read two poems, by Oliver Baez Bendorf and Richard Siken, whose shared centering of names articulate a relational self-indulgence in their proposed call-and-response.
Future Fatigue
Authors: Malatino Hil
Published: November 2019

This essay explores the ways that teleological narratives of transition come coupled with corresponding affective narratives that frame life “pre” transition as characterized by a reductively bleak emotional surround and cathect life “post” transition to a bright-sided promise of social ease, domestic comfort, and existential peace. Building on Lauren Berlant's theorization of cruel optimism and the work of Tobias Raun and Laura Horak on video narratives of hormonal and surgical transition, I position the figuration of futurity in these narratives as generative of a form of intense anticipatory anxiety in the present, one that may actually impede the flourishing of trans subjects, particularly those who encounter difficulty accessing technologies of transition. These teleological affective narratives generate an inhabitation of the present as a dwelling in lag—a form of being out of temporal sync, left behind, with the life one desires deferred (perhaps perennially). As an ameliorative to the effects of such cruelly optimistic futural narratives, I theorize a trans for trans (t4t) praxis of love, drawing on the fantastic and dystopic imaginaries at work in the fiction of Kai Cheng Thom and Torrey Peters to account for the creative and caring acts of trans intimacy that render life in the interregnum—in the moments during transition, which may very well not have a definite end—not only livable but also, sometimes, joyous.
Foreign media today: major corporations and monopolistic associations
Authors: Маркина Юлия , Markina Yulia , Хорольский Виктор , Horol'skiy Viktor
Published: November 2019

Processes of concentration and monopolization in the Western mass media in the conditions of postindustrial (information) society are considered. The advantages and disadvantages of media concentration are characterized, including from the point of view of the study of international and civilizational aspects of media globalization. Multicultural facets of media monopolization are analyzed taking into account changes in the style of journalistic discourses in the Internet era.
Meets the requirements of the Federal state educational standards of higher education of the last generation.
It is aimed at bachelors, undergraduates and graduate students of journalism faculties, as well as specialists in public relations, political strategists, journalists-practitioners.
Neoangiogenesis in the dynamics of testicular seminoma progression
Authors: Potapov S. M. , Pliten O. M. , Horhol N. I.
Published: November 2019

Testicular germ cell tumors (TGCT) is a group of neoplasms which develop from the germ cell epithelium and account 94-96% of all testicular tumors. Seminoma is the most common testicular germ cell neoplasm and accounts for about 50% of all TGCT.There is an increasing evidence that metastatic disease in both early and late stages depends on the degree of tumor vascularization. But despite the large number of publications on this subject, the ways of new vessels formation in invasive neoplasms and effect of the intratumoral vessels density on overall and relapse-free survival rate remain unclear.The performed investigation of neoangiogenesis in the dynamics of testicular seminoma progression revealed: significant increasing of relative area of CD31 and CD34 expression as well as vascular density during transition from the initial to the late stages of tumor progression; formation of intratumoral vessels in the seminoma occurs by angiogenesis and vasculogenesis with participation of progenitor endothelial cells; seminoma is characterized by vasculogenic mimicry in the form of channels formation that do not have endothelial lining.
Flipped Learning Methodology in Professional Training of Future Language Teachers
Authors: Nikitova Inna , Kutova Svitlana , Shvets Tetiana , Pasichnyk Olena , Matsko Vitaly
Published: November 2019

The purpose of the study was to examine and evaluate the impact the “flipped classroom” model-based learning environment accompanied by multimedia-based textbook entitled “Ukrainian language (for professional purposes)” provides for the language proficiency and learning styles of the university students majoring in language and literature teaching. A multimedia textbook “Ukrainian for Special Purposes” was designed for the study. A multi method approach was used to gather feedback and quantitative methods were used to analyze the data. Specifically, a 2X2 split-plot design was used to analyze the quantitative data and the two-way ANOVA for Mixed Measures was used to designate the main effects for column and row factors and their interaction effect related to the efficacy of the experiment. Textalyzer software was used to process the students’ responses to survey questions. The results reported a shift in student preferences in learning, including a greater desire to engage independently with computer-assisted work, quicker problem solving, increased motivation to study, and improved time management and lifelong learning skills. The study may better inform building the learning process for the students with limited learning opportunities or studying the distance learning model. Despite the experimental group involving only the students majoring in Economics, this methodology could be applicable to teaching Ukrainian for specific purposes to other majors, such as: Psychology, Educational Management, etc. The research is advancing the knowledge of integration multimedia tools into teaching, and specifically the use of multimedia textbooks in the “flipped classroom” settings to deliver the language course to the students majoring in literature and language teaching.
A Proposal for Holistic Assessment of Computational Thinking for Undergraduate: Content Validity
Authors: Sondakh Debby Erce , Osman Kamisah , Zainudin Suhaila
Published: November 2019

Studies have acknowledged computational thinking (CT) as an efficient approach for problem-solving particularly required in digital workplaces. This research aims to identify indicators for a holistic CT assessment instrument for undergraduate students. A three-round fuzzy Delphi study has been conducted to gain comprehensive opinions and consensus from undergraduate lecturers of computer science disciplines and experts from the information technology industry. In round 1, the experts judged a set of predefined indicators describing CT skills and attitudes identified from the literature, while rounds 2 and 3 focused on variables selection. The consensus was achieved on holistic CT, and the indicators are teamwork, communication, spiritual intelligence, generalization, problem-solving, algorithmic thinking, evaluation, abstraction, decomposition, and debugging. Results demonstrate the importance of attitudes in the process of solving a problem and suggest higher education institutions to consider holistic CT in preparing qualified future graduates. Many CT studies focused only on the skills of CT. This study outlines the assessment indicators that consider both CT skills and attitudes, particularly at the undergraduate level.
Treatment of statins drug (pravastatin and rosuvastatin) in water by electro-Fenton process: Kinetics of degradation/mineralization and optimization of experimental conditions for a biological post-treatment
Authors: Beqqal Nisrine , Sh yahya Muna , Miloud EL Karbane , Chakchak Hind , Kacem El Kacemi
Published: November 2019

The treatment of pravastatin and rosuvastatin contaminated water as much as toxic and persistent organic pollutant was carried out by Electro-Fenton method EF. Several experiments were conducted in a cell compartment equipped with a platinum anode and a carbon felt cathode. The effects of several parameters such as the applied current and the catalyst Fe2+ concentration have been studied. Mineralization aqueous solutions of pravastatin followed by the chemical oxygen demand COD gave a higher degree of reduction of more than 90% for 6 hours of treatment at a current of 100 mA and Fe2+ concentration of 0.2 mM. The study of the degradation kinetics was followed during electrolysis by HPLC giving a pseudo first order reaction using a current of 100 mA and Fe2+ concentration of 0.1mM. A number of intermediate products for pravastatin and rosuvastatin have been identified using HPLC and liquid chromatography-mass spectrometry analyses. Biodegradability of the pre-treated solutions of two statins by EF was evaluated in order to decide the optimal moment to introduce the biological process. It was given by the ratio BOD5/COD which increases from 0 initially to 1.3 after 2 hours for pravastatin and from 0 initially to 1.5 after 3 hours for rosuvastatin as the COD decreases. It implies that EF tends to enhance the biodegradability and could be used as a pre-treatment step for biological treatment.
Synthesis and adsorption properties of activated carbon from KOH-activation of Moroccan Jujube shells for the removal of COD and color from wastewater
Authors: Kachabi Mohammed , El Mrabet Imane , Benchekroun Zineb , Nawdali Mostafa , Hicham Zaitan
Published: November 2019

This study aimed to investigate the applicability of new low-cost activated carbons with a high surface area prepared by KOH chemical activation of jujube shells (denoted JSAC) as adsorbent of Chemical Organic Demand (COD) from wastewater.The prepared activated carbon is characterized by various physical-chemical methods to determine their morphological, textural and chemical characterization, including nitrogen adsorption-desorption isotherms, Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), Boehm titration method and the pH of the point of zero charge (pHPZC).Then they were used as an adsorbent for the removal of COD from wastewater collected from Fez area. Adsorption equilibrium and kinetic data were determined and fitted to several adsorption isotherms and kinetics models, respectively. The results showed that the Langmuir isotherm fitted well the equilibrium data of COD on JSAC adsorbent; whereas, the kinetic data were best fitted by the pseudo-second-order model. This adsorbent showed the highest removal efficiency for COD (72%) and the grey colour of the wastewater (83%) for an optimum dose of 0.5 gJSAC. L-1. Results from the study showed that JSAC activated carbon could be utilized as an effective and less expensive adsorbent for the removal of COD in wastewater.
Removal of Basic Dyes from Aqueous Solutions by Adsorption onto Moroccan Clay (Fez City)
Authors: Hicham Zaitan , Bencheqroun Zineb , El Mrabet Imane , Kachabi Mohammed , Nawdali Mostafa , Neves Isabel
Published: November 2019

The main objective of this study was to investigate the potential of natural clay obtained (from Fez city, Morocco) as an adsorbent for the removal of basic dyes (Astrazon Blue BG and Astrazon Yellow 7GLL) from liquid effluents. Natural clay was characterised using different physical-chemical methods, including nitrogen adsorption-desorption isotherms, X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), pH of the point of zero charge (pHPZC) and Boehm titration method. The clay was tested to remove various textile dyes from the aqueous solution at room temperature. Parameters such as initial dye concentration, solution pH, adsorbent dosages and contact time were performed in a batch system for controlling the operating conditions. Experimental results data indicated that the adsorption process is a fast and spontaneous reaction. A pseudo-second-order kinetic model provides the best fit to the experimental data of BG and YL adsorption onto the natural clay. Theadsorption isotherm data of both the dyes onto the natural clay were fitted well to the Langmuir model. A maximum monolayer adsorption capacity of 101 mg.g-1 for BG and 127 mg.g-1 for YL are obtained at 298.15 K.The results suggest that the natural clay could be used as an inexpensive adsorbent for the removal of the textile dyes from aqueous solutions.
The dielectric and electrical proprieties of Ethylcarbazole family based copolymer
Authors: Bouaamlat Hussam , Hadi Nasr , Sadki Hayat , Bennani Mohammed , Abdi Farid , Lamcharfi Tajeddine , Bouachrine Mohammed , Abarkan Mustapha
Published: November 2019

The dielectric and electrical proprieties of Ethylcarbazole family based copolymer such as Poly(Ethylcarbazole-Terphenyl) (PEcbz-Ter), Poly(Ethylcarbazole-Anthracene) (PEcbz-Ant) and Poly(Ethylcarbazole-Furan) (PEcbz-Fur) were investigated over the frequency range from 1 kHz to 2 MHz. The dielectric constant ε'r for (PEcbz-Ter), (PEcbz-Ant) and (PEcbz-Fur) pellets was found to decrease as the frequency increases and it was recorded a value of 11 7 , 11 6 and 7 6 respectively at 1 kHz. The dielectric loss was investigated and have a value below 1% at 11 kHz, which is suitable for several energy storage applications.
High dielectric constant of (1-x)(Na0.5Bi0.5)TiO3-xBaTiO3 prepared by the hydrothermal method
Authors: Mesrar Mohammed , Lamcharfi Tajdine , Echatoui Nor-Said , Abdi Farid , Harrach Ahmed
Published: November 2019

In this study, hydrothermal synthesis conditions for the formation of (1-x (Na0.5Bi0.5)TiO3-xBaTiO3Â  (x=0; 0.03; 0.05; 0.06; 0.07; 0.08 and 0.1)Â  compounds were investigated. The process parameters such as the alkaline conditions and heating treatment (temperature, time) as well the influence of the (Na, Bi)/Ba ratio were investigated in detail. The as-prepared NBT powders were characterized by X-ray powder diffraction, scanning electron microscope (SEM) and dielectric measurements. Taking into account NBT behavior draws consideration to phenomena of the ion ordering, coexistence of various phase regions in a crystal lattice, phase transition diffusion and a considerably new phenomenon: the existence of a very high dielectric constant at low frequency. Our result presents a simple preparation route for low-cost and high-purity.
Dielectric and ac conductivity of ilmenite-type CdTiO3 ceramic
Authors: Bahloul Radouane , Sayouri Salaeddine , Lamcharfi TajEddine
Published: November 2019

Cadmium titanate CdTiO3 powder sample was prepared using the sol-gel route and calcined at 900°C. The dependence of the permittivity, loss tangent (tan δ) on the temperature in the range 40–600°C, and frequency in the range 103–2.106 Hz for the pure hexagonal ilmenite is reported. The ln(σac) versus T plots suggest that the conduction mechanism is of ionic hopping nature. The evolution of ln(σac) as a function of frequency suggests that the ionic hopping conduction decreases with the rise in temperature. The complex impedance plots revealed two depressed semicircular arcs indicating the bulk and interface contributions. The bulk resistance was found to increase with a decrease in temperature exhibiting typical semiconductor-like behavior
Performing migration in Vienna: The Volkstheater trilogy
Authors: Angelaki Vicky
Published: November 2019

This article is concerned with the example of Vienna's Volkstheater in asking how major European cultural institutions might affectively and effectively engage with the refugee crisis and asylum seeking especially following what has become known as the 'Long Summer of Migration' (2015). It discusses what we might describe as the 'Migration Trilogy' of pieces co-developed by Yael Ronen and the performer ensembles involved, namely, the plays Lost and Found, Niemandsland and Gutmenschen.
Performing im/mobility: Going beyond the testimony trap
Authors: D'Onofrio Alexandra
Published: November 2019

In 2012 Alexandra D'Onofrio set up a series of theatre workshops as part of a larger research project using a variety of arts and creative techniques to carry out a methodological investigation into the interior and imaginative lifeworlds of migrants. A group of actors and researchers were joined by three young Egyptian migrants in a workshop using drama exercises to illuminate the ways in which they formed stories to narrate their lived experiences. This piece discusses the impact of distorted media discourses around migration and the ways in which audio-visual, performative and textual anthropological representations of migration can be used to highlight the political responsibility of bringing people's experiences, aspirations, contradictions and voices into the public realm.
Four thoughts on place and The Jungle
Authors: Lamont Bishop Olivia
Published: November 2019

, by Joe Murphy and Joe Robertson, is a play that focuses on the experiences of the residents and volunteers of the refugee camp known as the Calais Jungle, where London audiences experienced a recreation of this camp in a West End theatre. This intervention discusses the ethics surrounding the theatrical recreation of such places which are associated with conflict and displacement. Considering the positionality of the audience and the creators of the play, as well as analysing its institutional framing, this piece examines the issues inherent within recreating places at a distance.
ASESMEN EUTROFIKASI PERAIRAN PESISIR MENGGUNAKAN METODE INDEKS TROFIK (TRIX)
Authors: Prayitno Hanif Budi
Published: November 2019

EUTROPHICATION ASSESSMENT METHOD FOR COASTAL WATER USING TROPHIC INDEX (TRIX). Eutrophication, a process in which water bodies experience excessive growth of aquatic plants due to accumulation of land-originated nutrients especially phosphorus and nitrogen, has become a worldwide coastal environmental problem. Its negative impacts have been well known including oxygen depletion, harmful algal blooms, biodiversity reduction and ecosystem degradation. Unfortunately, the occurrence of those impacts is often not well anticipated as the instruments for assessing the quality of coastal and marine environment are weak and hardly available. Therefore, there has been a growing concern in developing appropriate methods for assessing coastal and marine eutrophication. One of the most widely used methods is trophic index (TRIX) due to its good efficacy. However, it is still questionable whether TRIX is a universal index of eutrophication or the scaling of TRIX should be region specific.
PENERAPAN TEKNOLOGI HIDROAKUSTIK DI BIDANG ILMU DAN TEKNOLOGI KELAUTAN
Authors: Lubis Muhammad Zainuddin , Surya Ganda , Anggraini Kasih , Kausarian Husnul
Published: November 2019

APPLICATION OF FIELD HYDROACOUSTIC TECHNOLOGY FOR MARINE SCIENCE AND TECHNOLOGY Utilization hydroacoustic methods in recent years have become increasingly effective for estimating the abundance of marine fish, especially fish stocks, where is impossible to do with conventional methods approach. Widely hydroacoustic technology has been used to map and classify the content of the resource base of waters and benthic animals that are on the bottom, type of substrate and benthic biota. Target Strength (TS) is the most important factor in the detection and prediction of fish stocks by using hydroacoustic. The TS is a measure that can describe the ability of a target to reflect sound waves that come about it. In the propagation of sound waves, the amount of energy per second will be flowing through the unit certain area perpendicular to the direction of propagation. The amount of energy per second crossing a certain area of the unit refers to as the intensity of the wave. The system of detection and measurement of underwater involves three components, namely medium, targets, and equipment. Sonar equation is built based on the similarity or balance between the parts of the received signal, the desired (called signal) and the unwanted parts (referred noise or noise), depending on the specific sonar functions are applied.
MENGENAL SISTEM GNOTOBIOTIK DAN PERANANNYA PADA BUDIDAYA BIOTA LAUT
Authors: Rizqi Marenda Pandu
Published: November 2019

INTRODUCTION TO GNOTOBIOTICS AND ITS ROLE IN MARICULTURE. Initial colonization of microbial community in marine larvae is one of the important stage in larval development in terms of subsequent growth, immunostimulation, and pathogen elimination. Gearing towards environmentally sustainable manner of aquaculture, early microbial manipulation in larval stage may provide an alternative in efficient and productive larviculture. One of the tool to further study the host-microbe interaction is through in-vivo culture of axenic and gnotobiotic larvae, in which a germ-free larvae was produced, and subsequently induced with single strain benign microbe to observe its response and characteristics. Several methods and protocols to obtain axenic-gnotobiotic condition is highlighted, along with the current development of gnotobiotic research, particularly in commercially valuable saltwater fish, e.g. Atlantic cod and European seabass. The development of novel gnotobiotic protocols combined with different scientific approach, e.g. gene expression, quorum sensing, immunostimulants, and purified diets may provide better insight in host-microbe interaction of marine biota, which in turn will benefit the implementation of specific probiotics, prebiotics, diets, and microbial regulation in marine larviculture.
PESQUISA EM EDUCAÇÃO: EDUCAÇÃO COMPARADA A PARTIR DE ESTUDOS DE NÓVOA E FERREIRA
Authors: Zucchetti Dinora Tereza
Published: November 2019

O artigo de revisão bibliográfica versa sobre a pesquisa Educação Comparada, apresentando-a como campo de conhecimento que contribui para a grande área da Educação. Fá-lo a partir de estudos de Nóvoa e Ferreira, professores da Universidade de Coimbra, evidenciando a dimensão problematizadora do conhecimento que considera novas perspectivas para o tempo e o espaço em educação. Com a Educação Comparada, a emergência de um Outro, sujeito de aprendizagem que, não somente, se inscreve numa realidade, mas emerge como parte de uma filiação disciplinar, cultural e ideológica (FERREIRA, 2014). Na busca por dar a compreender a Educação Comparada, na perspectiva dos autores, apresentam-se a problemática, os objetivos e a metodologia de uma investigação sobre educação integral, em curso, no estado do Rio Grande do Sul.
Fresh and Lean Pork Consumption in Relation to Nutrient Intakes and Diet Quality among US Adults, NHANES 2005-2016
Authors: An Ruopeng , Nickols-Richardson Sharon M , Alston Reginald , Clarke Caitlin
Published: November 2019

Objective: In this study, we assessed the influence of pork consumption on nutrient intakes and diet quality among US adults. Methods: We used a nationally-representative sample (N=27,117) from the National Health and Nutrition Examination Survey (NHANES) 2005–2016
waves for analysis. First-difference estimator addressed confounding bias from time-invariant non-observables (eg, eating habits, taste preferences) by using within-individual variations in pork consumption between 2 nonconsecutive 24-hour dietary recalls. Results: Approximately 19.4%,
16.5%, and 16.1% of US adults consumed pork, fresh pork, and fresh lean pork, respectively. Prevalence of pork, fresh pork, and fresh lean pork consumption differed by sex, race/ethnicity, and education level. Increased fresh and lean pork rather than total pork intake was related to marginally
improved nutritional intakes (ie, protein, magnesium, potassium, selenium, zinc, phosphorus, and vitamins B1, B2, B3, and B6) with lesser increases in daily total energy, saturated fat, and sodium intakes. Pork, fresh pork, and fresh lean pork consumption
was not found to be associated with the Healthy Eating Index (HEI)-2015 score. Conclusion: US adult pork consumers may increase their share of fresh and fresh lean pork over total pork consumption in an effort to increase their daily intakes of beneficial nutrients while minimizing
intakes of energy, saturated fat, and sodium.
On the Hirzebruch–Kobayashi–Ono proportionality principle and the non-existence of compact solvable Clifford–Klein forms of certain homogeneous spaces
Authors: Bocheński Maciej Franciszek , Tralle Aleksy
Published: November 2019

This article continues a line of research aimed at solving an important problem of T. Kobayashi of the existence of compact Clifford–Klein forms of reductive homogeneous spaces.
We contribute to this topic by showing that almost all symmetric spaces and 3-symmetric spaces do not admit solvable compact Clifford–Klein forms (with several possible exceptions).
Our basic tool is a combination of the Hirzebruch–Kobayashi–Ono proportionality principle with the theory of syndetic hulls.
Using this, we prove a general theorem which yields a sufficient condition for the non-existence of compact solvable Clifford–Klein forms.
Food transformed? Taphonomical investigation into a potentially symbolic role of crops at two Neolithic settlements in northern Germany
Authors: Filipović Dragana , Brozio Jan Piet , Kaczmarek Jan , Müller Johannes , Kirleis Wiebke
Published: November 2019

The two studied Neolithic sites in northern Germany, Oldenburg LA232 and Oldenburg LA191, yielded remains of residential architecture and evidence of every-day activities, including food storage and processing. None of the excavated features were attributed a symbolic or ritual meaning. However, in more than one case relatively large amounts of food have been found in contexts unlikely to contain food, even as a result of post-depositional disturbance. These contexts are postholes, and this phenomenon is also seen at some other sites in the region from this and later periods. Was food intentionally deposited in these features and was it given a different meaning? Was it transformed into a symbolic object, perhaps with a role in a ritual performed during house construction or demolition? We try to answer these questions by studying the quantity and taxonomic range of the plant remains recovered from these and other plant-rich deposits at the two sites, and by analysing the nature of the context and of the associated ecofacts and artefacts. We highlight possible symbolic or ritual aspects of behaviour by the residents of the two Neolithic settlements and we put forward the idea of a potential house closure act in which plants seem to have played a part.
Brand Image and its Determinants: A Stochastic Frontier Approach Analysis
Authors: Goyal Vinay
Published: November 2019

This paper addresses an important issue to find relationship between the brand image and its determinants. Based on a data set of 136 brand characteristics measured for 700 top American national brands obtained from a survey of 4769 respondents as well as secondary sources (Lovett, Peres, and Shachar. 2014. “A Data Set of Brands and Their Characteristics.” Marketing Science 33 (4): 609–17), this study adopted an established econometrics approach (Stochastic frontier analysis) that has not been extensively applied in the marketing literature. The approach discussed in this paper can be used as an analysis framework where the concept of efficiency is brought into the picture in analyzing the relationship between the brand image with its associates. It is found that competency and familiarity are two main features that increase brand equity, whereas perceived risk and excitement decreases it.
Current Biochemical Applications and Future Prospects of Chlorotoxinin Cancer Diagnostics and Therapeutics
Authors: Khanyile Sbonelo , Masamba Priscilla , Oyinloye Babatunji Emmanuel , Mbatha Londiwe Simphiwe , Kappo Abidemi Paul
Published: November 2019

Chlorotoxin (CTX) is a minute 4 kDa protein made up of 36 amino acid residues, commonlyknown for its binding affinity to chloride channels and matrix metalloproteinase-2 (MMP-2)of glioma tumors of the spine and brain. This property and the possibility of conjugating thispeptide to nanoparticles have enabled its diverse use in various biotechnological and biomedicalapplications for cancer treatment, such as in tumor imaging and radiotherapy. Because of thefascinating biological properties CTX possesses, elucidating its mechanism of action may holdpromise for the development of new and effective therapeutic drugs, as well as more sensitiveand highly specific cancer-screening kits. This article therefore reviews the currently knownapplications of CTX and suggests diverse ways in which it can be applied for the design ofimproved drugs and diagnostic tools for cancer.
Dissolution Enhancement of Atorvastatin Calcium by Cocrystallization
Authors: Al-Kazemi Reham , Al-Basarah Yacoub , Nada Aly
Published: November 2019

Purpose: To enhance the dissolution rate of the poorly soluble drug atorvastatin calcium (ATC) bycocrystallization with selected coformers. Enhancement of the dissolution rate and solubility of thedrug, which is classified as Class II of the Biopharmaceutical Classification System (BCS), is expectedto enhance the bioavailability.Methods: Two methods were used for preparing the cocrystals, solvent drop grinding (SDG) andsolvent evaporation (SE) method using 1:1, 1:3, and 1:10 drug-coformer molar ratios. Glucosaminehydrochloride (GluN) and nicotinamide (NIC) were investigated as coformers. The cocrystals,their physical mixtures, and the raw ATC were characterized by fourier transform infrared (FTIRspectroscopy), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), massspectroscopy (MS), scanning electron microscopy (SEM), solubility, and dissolution rate studies.Results: SDG and SE were effective in improving the dissolution rate of ATC with both coformers.Drug: coformer ratio 1:3 was optimum. The solubility values for ATC, GluN-, and NIC-cocrystals were26, to 35 and 50 μg/mL, respectively. The dissolution rate of ATC from cocrystals was > 90% after 5minutes, compared to 41% untreated ATC.Conclusion: Cocrystallization significantly improved the solubility and dissolution, in comparison tothe untreated ATC.
Niosomal Benzoyl Peroxide and Clindamycin Lotion Versus NiosomalClindamycin Lotion in Treatment of Acne Vulgaris: A RandomizedClinical Trial
Authors: Mohammadi Saman , Pardakhty Abbas , Khalili Maryam , Fathi Reza , Rezaeizadeh Maryam , Farajzadeh Saeedeh , Mohebbi Azadeh , Aflatoonian Mahin
Published: November 2019

Purpose: Combination of benzoyl peroxide (BPO) with topical antibiotics can lead to higherefficacy and less bacterial resistance, but it in turn increases adverse effects such as skinirritability and dryness. In this study, the efficacy of combination therapy of niosomal BPO 1%and clindamycin (CL) 1% is compared with niosomal CL in acne vulgaris.Methods: This is a double-blind clinical trial study on 100 patients with acne vulgaris inAfzalipour hospital in Kerman. Patients were randomly divided into 2 groups (case and control).The case group received niosomal combination of BPO 1% and CL 1%.The control groupreceived niosomal CL1%. The efficacy of treatment protocols was evaluated in 2nd, 4th, 8thand 12th weeks of treatment by counting lesions (severity and grading acne lesions) and qualityof life (QoL). Furthermore, side effect were evaluated at each treatment visits.Results: The reduction in mean percentage of acne lesions in case group (treated with BPO 1%and CL1%) (64.21%) was higher than control group (treated with niosomal CL 1%) (59.04%),but the statistical difference was not significant. Sum of excellent and good results were foundin 80% and 76.1% of case and control groups, respectively (P = 0.377). Also adding BPO to thetreatment formulation in case group did not increase adverse effects, as statistical differencebetween 2 groups was not significant.Conclusion: Combination of niosomal BPO 1% and CL 1% in treatment of acne vulgaris showedhigher efficacy with no increase in adverse effects in comparison with niosomal CL 1%, but thestatistical difference was not significant.
Evaluation of Immunogenic Effect of Toxoplasma gondii RecombinantSAG-1 Antigen with Propranolol as Adjuvant in BALB/c Mice
Authors: Abasi Esmaeil , Shahabi Shahram , Golkar Majid , Khezri Peyman , Mohammadzadeh Hajipirloo Habib
Published: November 2019

Purpose: Propranolol as a novel adjuvant, was used to evaluate the immunogenic effect of threedoses of recombinant SAG-1 (rSAG-1) antigen of Toxoplasma gondii in BALB/c mice for findingthe optimal dose, and was compared with efficacy of tachyzoite lysate antigen (TLA).Methods: Eight different groups of 15 BALB/c mice received different volumes of theimmunogenic material (three doses of r SAG-1 and one dose of TLA antigens), with or withoutpropranolol adjuvant, subcutaneously. The control group mice received only PBS. Three weeksafter the last immunization, the serum levels of IgG2a, IgG1 and IgG total antibodies againstTLA, splenic interleukin-5 (IL-5) and Interferon-gamma (IFN-γ) (produced against TLA) and thesplenic lymphocyte proliferation after adding TLA were measured to evaluate humoral andcellular immune responses. Challenge test was performed by subcutaneously injection of 1000alive and active tachyzoites in to five mice per each group and survival days for each group ofmice were recorded.Results: The mice group that received propranolol adjuvant and 20 μg of r SAG-1 antigenper dose of injection showed significantly more IFN-γ production, more proliferation ofsplenic lymphocytes and higher anti-TLA-specific IgG2a production (three main indexes forcell mediated immunity) in comparison with other groups. Moreover, in the challenge test,this group of mice had a significantly increased survival time, indicating the positive effect ofpropranolol in the more stimulating of cellular immunity that is necessary for toxoplasmosisprevention or suppress.Conclusion: Our results showed that T. gondii rSAG-1 antigen in combination with propranololas adjuvant (which can induce Th1 related responses) are good candidates for further study toa vaccine design.