bluuebunny/crossref_metadata_2025 huggingface dataset:
Studying the resection margins during organ-sparing operations and oncoplastic resections in patients with breast cancer
Authors: Khugaeva F. , Zikiryakhodzhaev A. , Rasskazova E. , Volchenko N. , Reshetov I.
Published: May 2024

Breast cancer (BC) comes to the forefront among the malignant neoplasms in the prevalence in women. The treatment of BC is complex; however, the surgical stage is the main one. Today, there are a lot of publications describing the characteristics of organ-sparing operations (OSOs) and oncoplastic resections (OPRs); however, There is no detailed description of the marking of resection margins. The development of the unified standard for morphopathological evaluation of surgical material and its analysis and will ultimately result in the clearer identification of a relationship between the resection margins and local recurrences, will eventually decline the number of reoperations. The authors give the results of their own investigation studying the resection margins in patients with BC (n=350) after OSOs and OPRs.
Cardiotone: pharmacological properties of hawthorn blood-red, possibility of use in patients with cardiovascular diseases
Authors: Dedov D.
Published: May 2024

Objective. To analyze the literature, which reflect the results of the study of the pharmacological properties of hawthorn blood-red and the possibility of using the above-ground part of the plant in the Russian drug Cardioton in patients with cardiovascular disease. Material and methods. An analysis was made of more than thirty scientific publications of Russian and foreign researchers, reflecting the use of blood-red hawthorn, as well as rose hips and royal jelly, which are components of the drug Cardioton, in patients with cardiovascular diseases. Results. The hawthorn-blood-red preparations have cardiotonic, coronary dilation, hypotensive, antiarrhythmic, antispasmodic and antioxidant effects. The drug Cardioton combines in its composition whole above-ground parts of hawthorn-blood-red - fruits, flowers and leaves. Conclusions. Use hawthorn-blood-red is associated with improvement in the general well-being of patients. The drug Cardiotone, produced by the Russian company "Parafarm" has antioxidant, cardioprotective, hypotensive, hypocholesterolemic, anti-inflammatory, metabolic effect and can be recommended for the complex prevention and treatment of cardiovascular diseases.
Effect of metabolic therapy on the state of the vascular bed in premenopausal dyslipidemia
Authors: Khabibulina M. , Shamilov M.
Published: May 2024

When scanning the common carotid arteries (CCA), it was found that patients with premenopausal arterial hypertension (AH) with dyslipidemia with reduced estradiol levels had an expansion of the CCA lumen, a decrease in the blood flow rate in the carotid arteries without hemodynamically significant stenoses, which may indicate the development of vascular maladaptation due to a violation of the autoregulation mechanism, due to remodeling of the vascular wall caused by hypoestrogenemia, and indicate more pronounced structural and functional changes in the vessel in the form of arteriosclerosis, increased stiffness of the vascular wall and the development of endothelial dysfunction. Combined therapy with an angiotensin-converting enzyme (ACE) inhibitor and BioDihydroquercetin has a positive effect on structural and functional changes in the vascular wall of the CCA, endothelial dysfunction improves lipid spectrum parameters, reduces the stiffness of the vascular wall of the arteries. The drug BioDihydroquercetin, produced with trade mark “Baikal Legend”, is a natural immunomodulator, antioxidant, capillaroprotector, strengthens blood vessels, improves blood microcirculation, it is recommended to slow down the aging process of the body
DETERMINAN POTENSI KECURANGAN LAPORAN KEUANGAN DI INDONESIA
Authors: Hairani Yuniar Is , Isnawati Isnawati
Published: May 2024

Penelitian ini berangkat dari maraknya kasus fraud pada perusahaan yang terjadi pada PT Kimia Farma Tbk dan PT Indofarma Tbk. Kajian ini ditujukan guna dapat melakukan pengujian variabel penyebab fraud dalam mendeteksi potensi terjadinya fraud di perusahaan manufaktur yang ada pada BEI periode tahun 2020-2022 yang mengacu pada fraud hexagon theory. Kajian ini mengusulkan enam hipotesis yang diuji dengan f-score model. Kajian ini menerapkan data sekunder yang didapatkan dari laporan keuangan tahunan perusahaan periode 2020-2022 yang selanjutnya dianalisis dengan menggunakan variabel-variabel dalam fraud hexagon theory. Hasil penelitian memperlihatkan jika External Presure yang dikalkulasi dengan DAR berdampak pada potensi terjadinya kecurangan laporan keuangan sementara External Auditor Quality, Change in Auditor, Change in Dirctor, Proyek Pemerintah  yang dihitung dengan variabel dummy dan Ceo’s Picture yang dihitung berdasarkan jumlah foto pemimpin perusahaan tidak berdampak pada kemungkinan pelanggaran laporan akuntansi.
Pengaruh Sertifikat Halal, Legalitas Usaha, dan Kualitas Kemasan dalam Membentuk Keputusan Pembelian Konsumen Pada Produk Mixue Dikota Mataram
Authors: Hafizi Muhammad Aziz , Athar Handry Sudhiarta
Published: May 2024

Mixue's presence raises doubts due to uncertainty about its halal status, as it currently lacks the necessary halal certification required in the Indonesian market. This has sparked concerns among consumers, especially given China's majority non-Muslim population. The uncertainty surrounding Mixue's halal status has led to skepticism among a significant portion of the Indonesian population. While some individuals prioritize halal food products, others are indifferent, choosing to buy Mixue products regardless of their halal status. Many consumers feel the need to ensure a product's halal status before making a purchase. This research aims to explore the importance of a Halal Certificate, Business Legality, and Packaging Quality in shaping consumer purchase decisions for Mixue products in Mataram City. The study utilized a sample of 100 respondents who are consumers of Mixue products in Mataram City. The findings reveal that both the Halal certificate and packaging quality have a positive and significant impact on the purchase decisions of Mixue products in Mataram City. However, business legality does not show a positive and significant influence on the purchase decisions of Mixue products in Mataram City. These results indicate that the Halal certificate and packaging quality are effective in enhancing purchase decisions, while business legality has a less pronounced impact on the purchase decisions of Mixue products in Mataram
HÁBITOS ALIMENTARES DE PEIXES-BOI MARINHOS (TRICHECHUS MANATUS) EM VIDA LIVRE E MANTIDOS SOB CUIDADOS HUMANOS NO LITORAL BRASILEIRO
Authors: Villela Júlia Bastos , Maia Isabela Silveira , Coelho Isabelle Passos , Andriolo Artur
Published: May 2024

O peixe-boi-marinho (Trichechus manatus) é um mamífero aquático pertencente à ordem Sirenia, cuja distribuição abrange desde o sudeste dos Estados Unidos até o litoral norte do Brasil e é classificado
A IMPORTÂNCIA DO EXERCÍCIO FÍSICO NO TRATAMENTO DA PARALISIA CEREBRAL INFANTIL: UMA REVISÃO DE LITERATURA
Authors: Carvalho Ruy Miguel Oliveira , Rodrigues Pedro Mariano da Silva , Gomes Daniel Rodrigo de Lima , Barbosa Caio Felipe Rodrigues
Published: May 2024

INTRODUÇÃO: De acordo com o Ministério da Saúde, a paralisia cerebral (PC) infantil ocorre em 2 crianças a cada 1000 nascidos vivos, sendo essa uma doença que pode variar em intensidade devido às vari
DEPRESSÃO SIMULANDO DEMÊNCIAS: DESVENDANDO A COMPLEXA RELAÇÃO ENTRE SAÚDE MENTAL E COGNIÇÃO
Authors: Matos Lara Stephanie Profiro de , Vieira Mariana Oliveira Dumont , Silva Neto Francisco Marques da , NOGUEIRA GUILHERME NOBRE , Gonçalves Rafaela Fernandes , Isolan Gustavo Rassier
Published: May 2024

INTRODUÇÃO: A saúde mental continua a ser um campo de pesquisa em constante evolução. Nesse contexto, uma área de interesse crescente é a relação entre a depressão e as demências. Várias fontes confiá
ANÁLISE DO EFEITO DO PEPTÍDEO DE FEIJÃO NO TRATAMENTO NEUROINFLAMATÓRIO
Authors: Barros Camilla Rayza Dos Santos , Ingred Julia , Carvalho Glaucia Lemes de , Pedreira Angela Guimarães , Ribeiro Juliana Vila Verde , Batista Karla de Aleluia
Published: May 2024

Introdução: Atualmente muitas pesquisas vem tomando destaque em relação ao uso de nanopartículas (NPS) com compostos bioativos no tratamento da neuroinflamação. A neuroinflamação ocorre de forma natur
5 Diretrizes para um Planejamento Docente Participativo e Inclusivo Voltado ao Ensino de Discentes Surdos no Contexto da Educação Profissional e Tecnológica
Authors: Andrade Lúcio Costa de , Melo Filho Ivanildo José de
Published: May 2024

Livro digital com a finalidade de proporcionar por meio de diretrizes pedagógicas orientações para a prática docente inclusiva voltado ao ensino de discentes Surdos na Educação Profissional e Tecnológica.
Regulatory Frameworks for Decentralized Finance (DeFi): Challenges and opportunities
Authors: Ngozi Samuel Uzougbo  , Chinonso Gladys Ikegwu  , Adefolake Olachi Adewusi
Published: May 2024

Decentralized Finance (DeFi) has emerged as a disruptive force in the financial industry, offering innovative solutions such as smart contracts, decentralized exchanges, and lending protocols. However, the regulatory landscape for DeFi remains uncertain and fragmented, posing challenges and opportunities for its development and adoption. This abstract provides an overview of the regulatory frameworks for DeFi, highlighting key challenges and opportunities. The regulatory landscape for DeFi is complex and varies significantly across jurisdictions. While some countries have embraced DeFi and blockchain technology, others have adopted a cautious approach, citing concerns such as money laundering, consumer protection, and financial stability. The lack of a harmonized regulatory framework has created uncertainty for DeFi projects and users, hindering mainstream adoption. One of the key challenges facing DeFi is the lack of clarity regarding regulatory compliance. DeFi projects often operate in a decentralized and borderless manner, making it difficult to determine which regulations apply. This ambiguity has led to regulatory scrutiny and enforcement actions in some cases, highlighting the need for clear and comprehensive regulatory guidelines. Despite these challenges, there are also significant opportunities for DeFi to thrive within a regulated framework. Regulatory clarity can provide legitimacy and credibility to the DeFi industry, attracting institutional investors and mainstream users. Moreover, regulations can help protect consumers and ensure the integrity of DeFi protocols, fostering trust and confidence in the ecosystem. To address the challenges and leverage the opportunities, stakeholders in the DeFi ecosystem, including regulators, policymakers, developers, and users, must collaborate to develop a balanced regulatory framework. This framework should prioritize innovation while addressing concerns related to security, privacy, and financial stability. By working together, the DeFi industry can navigate the regulatory landscape and unlock the full potential of decentralized finance for global financial inclusion and economic empowerment.
Legal accountability and ethical considerations of AI in financial services
Authors: Ngozi Samuel Uzougbo  , Chinonso Gladys Ikegwu  , Adefolake Olachi Adewusi
Published: May 2024

Artificial Intelligence (AI) is revolutionizing the financial services industry, offering unparalleled opportunities for efficiency, innovation, and personalized services. However, along with its benefits, AI in financial services raises significant legal and ethical concerns. This paper explores the legal accountability and ethical considerations surrounding the use of AI in financial services, aiming to provide insights into how these challenges can be addressed. The legal accountability of AI in financial services revolves around the allocation of responsibility for AI-related decisions and actions. As AI systems become more autonomous, questions arise about who should be held liable for AI errors, misconduct, or regulatory violations. This paper examines the existing legal frameworks, such as data protection laws, consumer protection regulations, and liability laws, and assesses their adequacy in addressing AI-related issues. Ethical considerations in AI implementation in financial services are paramount, as AI systems can impact individuals' financial well-being and access to services. Issues such as algorithmic bias, transparency, and fairness are critical in ensuring ethical AI practices. This paper discusses the importance of ethical guidelines and frameworks for AI development and deployment in financial services, emphasizing the need for transparency, accountability, and fairness. The paper also examines the role of regulatory bodies and industry standards in addressing legal and ethical challenges associated with AI in financial services. It proposes recommendations for policymakers, regulators, and industry stakeholders to promote responsible AI practices, including the development of clear guidelines, enhanced transparency measures, and mechanisms for accountability. Overall, this paper highlights the complex interplay between AI, legal accountability, and ethical considerations in the financial services industry. By addressing these challenges, stakeholders can harness the full potential of AI while ensuring that it is deployed in a responsible and ethical manner, benefiting both businesses and consumers.
Sensory stimulation interventions in ICU: A comprehensive systematic review on enhancing consciousness in unconscious patients
Authors: Sheetal Bhatt  , Surendra Kumar Meena  , Neha Jain  , Tarini Prasad Pani
Published: May 2024

Background: Unconsciousness is a common and critical condition among patients admitted to the Intensive Care Unit (ICU). The potential impact of sensory stimulation as a therapeutic intervention for improving consciousness in these patients has gained increasing attention. This systematic review aims to evaluate the effectiveness of sensory stimulation programs in enhancing consciousness levels among unconscious patients in the ICU. Objectives: The primary objective of this review is to assess the effectiveness of sensory stimulation programs in promoting consciousness among unconscious patients in the ICU. Secondary objectives include identifying specific types of sensory stimulation techniques employed, examining eligibility criteria for patient inclusion in relevant studies, and exploring the reported results and conclusions relating to the review questions and objectives. Inclusion and Exclusion Criteria: Studies were included if they focused on sensory stimulation interventions for unconscious patients in the ICU. There were no restrictions on publication date or language. Studies that did not assess consciousness as an outcome or lacked sufficient data were excluded. Sources of Evidence: PubMed, EMBASE, Cochrane Library, and Web of Science will be searched to identify relevant articles. The last search was conducted on 2022. Assessment of Risk of Bias: The included studies were assessed for risk of bias using standardized tools, such as the PEDRO tool for randomized controlled trials. Discrepancies in the assessment were resolved through consensus or consultation with a third reviewer. Methods for Presenting and Synthesizing Results: Study characteristics, patient demographics, intervention details, outcomes, and results were extracted and summarized. Number of Included Studies and Participants: A total of 11 studies involving 500 participants were included. The characteristics of the included studies, such as study design, sample size, sensory stimulation techniques used, and outcome measures, were summarized. Charting Methods: Two independent reviewers will extract data and assess the eligibility of studies based on predefined inclusion and exclusion criteria. Any discrepancies will be resolved through discussion or consultation with a third reviewer. A standardized data extraction form will be used to record relevant information, including study characteristics, patient demographics, intervention details, outcomes, and results. Results: Upon completion of the data extraction process, study characteristics, sensory stimulation techniques, and reported results will be summarized. If feasible, a meta-analysis will be conducted to provide a quantitative synthesis of the findings. Any limitations and potential biases identified among the included studies will be discussed.
Assessment of acute impacts of cadmium chloride exposure on blood sugar level, body and organs weight in male albino Wistar rats and the ameliorative effects of ethanol leaf extracts of Tapinanthus bangwensis and Mangifera indica
Authors: Nnamso Effiong Essien  , Elijah Udo Afangideh  , Mercy Okon Akpan  , Rosemary Francis Usen  , Dorathy Edet Etim  , Promise-Godsfavour Mfon Bobson
Published: May 2024

Impacts of acute cadmium chloride exposure on blood sugar level, body and organs weights in male albino Wistar rats and the ameliorative effects of ethanol leaf extracts of Tapinanthus bangwensis and Mangifera indica were assessed. Twenty –five animals (125- 285 g) were randomly assigned five groups of five rats each. Groups 1-4 were orally administered with cadmium chloride (30%) below its LD50 each for three times at 2days interval before treatment with the plant extracts. Groups 1 and 2 were later treated with 300 mg/kg of T. bangwensis and M. indica respectively. Group3 were treated with 300 mg/kg of both extracts at 50:50 dosage ratio. Groups 4 and 5 were not treated and they served as negative and normal control respectively. Treatment was done via oral route for 14 days and all animals were allowed free access to commercial rat mash and water. Blood sugar and body weight were assessed at 2days interval after exposing animals to the heavy metal followed by treatment. Organs weights were taken after 14days treatment. The results of the blood sugar level revealed significant increase (P< 0.05) in group 4 (untreated) when compared to the normal control group and the groups treated with leaf extracts. Significant decrease was recorded in body weight of the untreated rats when compared to the treated and normal groups. There was significant decrease (P< 0.05) in the weight of testis and liver in group 4 when compared to groups 1,2,3 and 5, with significant decrease (P< 0.05) in the weight of the kidneys in group 1 when compared to groups 3 and 5. These results implied that cadmium chloride toxicity altered blood sugar levels, body and organs weights in the animals, however, the two plant extracts ameliorated these impacts and regulated the parameters to fall within their normal ranges.
Enhancing psychological insights through machine learning: A new paradigm for guided understanding
Authors: Dasaradha Ramayya Lanka  , Jammana Lalu Prasad  , Vankayala Anil Santosh  , Varanasi Avinash
Published: May 2024

On this age of technological advancement, the integration of system mastering's into human psychology is reworking our information of the human mind. This paper explores how advanced computational strategies are reshaping studies to find patterns of behaviour, emotional change, and tendencies in mental health. Evaluation of big datasets thru machine getting to know, together with social media and wearables, subtly detects feelings and predicts mental health troubles. Moral worries including privateness and bias require collaboration among psychologists, records scientists, and other specialists. Actual-world cases illustrate the function of device getting to know in detecting behaviour and advancing remedies. The want for interdisciplinary collaboration and ethical implementation is emphasised, with the promise of a destiny with advanced mental insights.
Health monitoring system using ECG and PPG techniques
Authors: Shagun Tyagi  , Harshit Singhal  , Tushar Gupta  , Kanishka Mehrotra  , Ajay Kumar
Published: May 2024

The demand for portable health monitoring systems has grown rapidly in recent years due to the increasing prevalence of chronic diseases and the need for continuous health monitoring. This article introduces the development and implementation of a portable health monitoring system using photo plethysmography (PPG) and electrocardiogram (ECG) technologies. The system integrates the Node MCU ESP8266 microcontroller, AD8232 ECG sensor, and MAX30100 sensor to measure vital signs such as heart rate and blood oxygen saturation level. The proposed system provides a cost-effective and efficient solution for real-time health monitoring, enabling early detection of abnormalities and timely intervention. The feasibility and performance of the system were proven through experimental tests.
Metaverse: Fission the architecture
Authors: Asif Zaman  , Mushfiqur Rahman Abir  , Md. Asgor Hossain Reaj  , Tanjil Hasan Sakib
Published: May 2024

Modern technology comes with new opportunities and difficulties since it is constantly evolving. The technology that has generated the utmost buzz and intrigue in recent years is Metaverse. Although Metaverse is not an entirely new word, it has attracted more attention because Facebook changed its name to Meta. However, despite the enormous interest and prospects, it still needs to be determined how ethical issues will be addressed and how users' privacy will be protected in the Metaverse system. Furthermore, the Metaverse system must earn the confidence and acceptance of its user by fulfilling the main criteria of Trustworthy AI. Therefore, this paper focused on making the Metaverse system trustworthy. This paper covered Metaverse's history, essential elements, the current business market, future opportunities, and challenges. Further, the manuscript discussed the pillars of trustworthy AI, its factors, and the way of trustworthiness. Finally, the paper combined these concepts and identified elements contributing to Metaverse's credibility.
Analysis of Manifold and its Application
Authors: Gyanvendra Pratap Singh  , Shristi Srivastav
Published: May 2024

Manifold learning is a field of study in machine learning and statistics that is closely associated with dimensionality reduction algorithmic techniques is gaining popularity these days. There are two types of manifold learning approaches: linear and nonlinear. Principal component analysis (PCA) and multidimensional scaling (MDS) are two examples of linear techniques that have long been staples in the statistician's arsenal for evaluating multivariate data. Nonlinear manifold learning, which encompasses diffusion maps, Laplacian Eigenmaps, Hessian Eigenmaps, Isomap, and local linear embedding, has seen a surge in research effort recently. A few of these methods are nonlinear extensions of linear approaches. A nearest search, the definition of distances or affinities between points (a crucial component of these methods' effectiveness), and an Eigen problem for embedding high-dimensional points into a lower dimensional space make up the algorithmic process of the majority of these techniques. The strengths and weaknesses of the new method are briefly reviewed in this article. In the field of computer graphics, we utilize a particular manifold learning method was first presented in statistics and machine learning to create a global, Spectral-based shape descriptor.
Effect of dexmedetomidine infusion on characteristics of spinal anesthesia with hyperbaric bupivacaine: A randomized controlled trial
Authors: Shanta Dutta  , Arpita Choudhury  , Debartha Bandopadhyay  , Sourav Mondal
Published: May 2024

Dexmedetomidine is a highly selective and potent α2 agonist having both sedative and analgesic properties. This study was aimed to assess the effects of intravenous dexmedetomidine on sensory, motor, haemodynamic parameters and sedation during subarachnoid block (SAB) with 0.5% hyperbaric bupivacaine. Sixty patients undergoing infraumbilical and lower limb surgeries were allocated into 2 groups, group D (n=30) received dexmedetomidine infusion at the rate of 0.5 µg/kg/h over an hour prior to SAB and continued till the end of surgery whereas patients in group C (n=30) received similar volume of normal saline infusion for the same duration. Onset of sensory block was 63.77 ± 7.42 s in group D compared with 126.2 ± 12.83s in group C. Two segment regression time was 177.03 ± 11.64 min in group D and 85.67 ± 10.32 min in group C and analgesia duration was 287.67 ± 14.84 min in group D and 149 ± 13.16 min in group C. Onset of motor block was 3.95 ± 0.65 min in group D and 4.5 ± 0.62 min in group C. Motor blockade duration was prolonged in group D compared with group C. There was significant difference between the groups in respect to block characteristics. Administration of intravenous dexmedetomidine during SAB hastens the onset and prolongs the duration of sensory and motor block. It also provides conscious sedation and additional analgesia.
Neuroanatomical alterations in brain disorder: A magnetic resonance imaging analysis
Authors: Halima Bello Kawuwa  , Charles Okanda Nyatega  , Ayesha Younis  , Mohammed Jajere Adamu
Published: May 2024

Background: Bipolar disorder is a serious mental disorder caused by strong mood fluctuations, affecting 2% of the world's population. People with bipolar disorder experience both manic and depressive episodes, which can lead to suicidal thoughts and changes in appetite, activity, and focus. There are different subtypes of bipolar disorder, with cyclothymic disorder being the milder of the two. Bipolar I is characterized by manic periods, while bipolar II is marked by hypomanic and significant depressive episodes. Bipolar disorder is a biological, genetic, and environmental condition that can affect anyone at any age. Methods: In this study, we enrolled a total of 49 bipolar disorder (BD) participants to 44 healthy control (HC) subjects. Bipolar disorder patients were enlisted with their consent using web portals, medical facilities, and local marketing. MRI contraindications, medical history, self-reported using a mood-altering medication, inadequate vision, and left-handedness were among the exclusion criteria. The various tissue structures which are: the gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) were examined using voxel-based morphometry (VBM) to ascertain these changes. We employed statistical parametric mapping (SPM) for both image processing and statistical analysis. Results: Our findings demonstrate that individuals with bipolar disorder showed a substantial volume decrease in both gray matter (GM) and white matter (WM), with gray matter (GM) and white matter (WM) volume decreases being more noticeable in the frontal, temporal, parietal, and occipital lobes. Additionally, individuals with bipolar disorder showed no CSF volume in any of the brain regions. Conclusion: Our VBM research backs up earlier studies that link changes in brain structure, particularly gray matter and white matter, to bipolar disorder. These discoveries shed more information on the neurology of bipolar disorder and could guide the creation of more potent diagnostic and treatment modalities.
Productivity optimization techniques using industrial engineering tools: A review
Authors: Tomal Das
Published: May 2024

This review explores productivity optimization techniques through the lens of industrial engineering tools. Industrial engineering serves as a critical discipline in enhancing efficiency and effectiveness across various industries. The abstract delves into methodologies, such as time and motion studies, Six Sigma, Lean principles, and operations research, which are instrumental in streamlining processes and improving productivity. These tools aid in identifying inefficiencies, eliminating waste, and enhancing overall performance. Through a comprehensive analysis of existing literature and case studies, this review highlights the diverse applications and benefits of industrial engineering techniques in optimizing productivity. Additionally, it discusses the integration of advanced technologies, such as automation, data analytics, and artificial intelligence, in modern productivity enhancement strategies. The review concludes with insights into future directions and potential challenges in leveraging industrial engineering tools for sustained productivity improvements in dynamic organizational environments.
Validation of ERP software and system architectures in a GxP controlled environment
Authors: Gaurav Pandey
Published: May 2024

ERP (Enterprise Resource Planning) is a software system which integrates all the business processes to run a company successfully. These software systems are widely used across all the industries like Manufacturing, Retail, Life Sciences, Banking and Finance etc. However, for pharmaceutical companies, the ERP systems must comply with GxP regulations which poses unique challenges. This whitepaper explores how to design and implement the software architecture of an ERP system in a GxP controlled environment.
Modulation of female reproductive hormones by Zingiber officinale and Allium sativum ethanol extracts administered singly and in combinations in female Wister rats
Authors: Daniel Ikechukwu Oraekei  , Peter Chibueze Ihekwereme  , Chukwuka Benjamin Uzodinma  , Marcellus Ejike Nnamani
Published: May 2024

The reproductive system in females is responsible for producing gametes, sex hormones, and maintaining fertilized eggs as they develop. The female reproductive system is regulated by a balance of hormones. This study was aimed at analyzing the modulation of female reproductive hormones including FSH, LH and prolactin by Zingiber officinale and Allium sativum separately and in combination in female Wister rat models. A total of 40 mature female Wister rats were divided into 8 groups (n=5). Groups 1 were treated with distilled water and served as the normal control. Group 2 were treated with Zingiber officinale ethanol extract alone. Group 3 were treated with Allium sativum ethanol extract alone. Group 4-8 were treated with combined administration of Zingiber officinale and Allium sativum ethanol extracts in the ratios of ZO:AS = 2:8, 4:6, 5:5, 6:4, and 8:2 respectively.. Treatment were administered for 90 days. On the 91st day of treatment after administration of the 90th doses, blood samples were collected by ocular puncture from all the rats from each of groups 1-8 for serum hormone testing. Zingiber officinale monotherapy increased the serum levels of FSH and LH and decreased the level of prolactin. The reverse was the case with Allium sativum monotherapy. The combination of the two herbs increased FSH and LH; or decreased prolactin only when the proportions of Zingiber officinale were higher. In conclusion, only the monotherapy of Zingiber officinale enhanced the serum levels of FSH and LH and modulated prolactin level to a desired level.
International enforcement of cryptocurrency laws: Jurisdictional challenges and collaborative solutions
Authors: Ngozi Samuel Uzougbo  , Chinonso Gladys Ikegwu  , Adefolake Olachi Adewusi
Published: May 2024

The rise of cryptocurrencies has presented new challenges for regulators around the world, particularly in terms of enforcement across international borders. This abstract explores the jurisdictional challenges faced by authorities in enforcing cryptocurrency laws and proposes collaborative solutions to address these challenges. Cryptocurrencies operate on a decentralized network, making them difficult to regulate within traditional legal frameworks. Jurisdictional issues arise when a cryptocurrency transaction involves parties in different countries, as it is often unclear which jurisdiction's laws apply. This ambiguity can lead to regulatory gaps and enforcement challenges, allowing illicit activities such as money laundering and terrorism financing to flourish. To address these challenges, collaborative solutions are needed. International cooperation between regulators, law enforcement agencies, and industry stakeholders is essential to ensure effective enforcement of cryptocurrency laws. This cooperation can take various forms, including information sharing, joint investigations, and the development of common regulatory standards. One example of successful collaboration is the Financial Action Task Force (FATF), an intergovernmental organization that sets standards for combating money laundering and terrorism financing. The FATF's guidance on virtual assets and virtual asset service providers has helped to clarify regulatory expectations and promote consistency in enforcement efforts across jurisdictions. Another example is the Joint Chiefs of Global Tax Enforcement (J5), a coalition of tax authorities from five countries that work together to combat international tax evasion. The J5's focus on cryptocurrency-related tax crimes highlights the importance of cross-border cooperation in tackling cryptocurrency-related illicit activities. In conclusion, while jurisdictional challenges remain a significant hurdle in the enforcement of cryptocurrency laws, collaborative solutions offer a path forward. By working together, regulators, law enforcement agencies, and industry stakeholders can address these challenges and ensure that the benefits of cryptocurrencies are realized while mitigating their risks.
A review of strategic decision-making in marketing through big data and analytics
Authors: Uzoma Okwudili Nnaji  , Lucky Bamidele Benjamin  , Nsisong Louis Eyo-Udo  , Emmanuel Augustine Etukudoh
Published: May 2024

This review paper delves into the transformative impact of big data and analytics on strategic marketing decision-making. Examining the integration of vast datasets and analytical tools in marketing strategies highlights how these technological advancements enable a deeper understanding of customer behavior, enhance product development, and provide a competitive edge. The review underscores the importance of data-driven insights in formulating personalized marketing strategies and the critical role of analytics in predictive and prescriptive decision-making. It addresses the challenges and ethical considerations associated with big data usage, emphasizing the need for robust data governance and ethical practices. The paper suggests future research directions, focusing on emerging technologies and methodologies that could further influence strategic marketing decisions.
ON SOME RESULTS OF PERFORMANCE ANALYSIS OF SURFACE HEAT EXCHANGE OF TRANSVERSE FLOW TUBE BUNDLES OF CYLINDRICAL PIPES AND PROFILED CHANNELSWITH COMPLEX CONFIGURATION IN THE AIR FLOW
Authors: Anisin Andrey , Anisin Aleksandr , Androsenko Valentina
Published: May 2024

Possible options are presented to arrange bundles of cylindrical smooth pipes of constant and variable cross-section and profiled channels made of thin-walled plates with two-sided spheroidal protrusions and hollows, allowing to intensify heat exchange, increase thermal energy efficiency and improve the mass and dimensional parameters of heat exchangers and devices.
The results of experimental studies of heat and aerodynamic characteristics are given, including those obtained for the first time, and performed on their basis using an original methods for a comprehensive analysis of performance indicators for individual design variants of the convective surfaces under discussion.
ROTARY-TABLE INSTALLATION FOR LIFE TESTS OF ABRASIVE WEAR
Authors: Abzhaev Marat
Published: May 2024

When developing new methods to make hardening coatings on the cutting tool surfaces of tilling machines, the main characteristic parameter determining the ability to serve for a long time, resisting external environmental influences and mechanical wear, is wear resistance. At the same time, this parameter should be determined before life tests in the field. Various stands and installations are available for this purpose. Each of them is characterized by their own advantages and disadvantages. Therefore, based on the specific production conditions, new devices are being developed. In this paper, a rotary-table installation of a specific design is developed for life tests of abrasive wear of various parts. A patent is obtained for it. The differences of this installation from existing analogues are the following: 1 – the pressure of the abrasive material layer on the test sample is regulated by deepening the sample into the abrasive medium; 2 - the test sample is under constant influence of the abrasive material by filling it with the required amount of abrasive materials; 3 – higher efficiency of the installation. This is achieved due to lower power consumption in the absence of friction forces between the sample bracket and the abrasive material.
Comparative life tests were carried out for two harrow teeth, the original tooth and the hardened one. The harrow teeth were tested on a simplified model of a developed installation. An experimental inverter vibration control unit of Kazan Federal University was used for treatment. Hardening was performed with a multi-rod electrode at an arc current of 60A. The frequency of the electrode vibration is 100 Hz. Tests show that the service life of hardened harrow teeth when treated by a vibrating arc with a multi-rod electrode is about 5-6 times higher than the service life of factory harrow teeth.
SELECTION OF TECHNICAL PARAMETERS OF SHOCK ABSORBING DEVICE ELEMENTS THAT DETERMINE ITS SAFETY
Authors: Romanov Igor' , Luk'yanchuk Aleksandr
Published: May 2024

The problems to plan and ensure a given level of reliability of mechanical systems at all stages of their design and operation occupy an important place in the problem of ensuring the quality of machine-building products. With a significant number of scientific methods and approaches to solving theoretical and applied issues of reliability theory, one of the key directions is to determine the reliability indicators of technical systems and their elements, in particular a wide range of products including sliding friction pairs with periodic impacts.
The study of failure origins, from the point of view of physical-mechanical processes occurring in surface layers of elements, under the influence of external factors, allows selecting parameters characterizing the functional state of the pair, and, as a result, its reliability. For example, for sliding friction pairs with periodic impacts, such a parameter is the geometric dimensions of the conjugate elements.
The decrease in the geometric dimensions of conjugate elements, due to wear, characterizes the rate of change of the initial parameter values to the maximum permissible ones determining the failure, and can be approximated by linear, power, exponential and other dependencies obtained from actual measurements. According to the obtained functional dependencies of parameter changes over operating time, it makes possible to determine the norm for the parameter regulating their pre-failure state, beyond which failure prediction is possible with varying probability, and, as a result, the reliability of the system as a whole.
The use of this method to reliability forecasting through the determination of the pre-failure state of the system can be projected onto technical objects, which performance indicators are geometric parameters that ensure the performance, first of all, of the functions of the elements themselves and the entire technical system, and worn out during operation.
MACHINING THE ENDS OF PART WORKPIECES
Authors: Mokrickiy Bori , Grigoriev Vladimir , Skripilyov Aleksandr , Maryin Sergey
Published: May 2024

The study objective is to increase turn process efficiency of corrosion-resistant stainless hard-to-machine steel 12X18H10T.
The task is to reduce tool costs.
Research methods are the following: full-field testing and simulation in deform software environment.
The novelty of the work: a new approach is formed to increase the durability of a metal-cutting tool for turning the ends of workpieces. This made it possible to find out the most rational coatings for different operating conditions.
Research results: recommendations are developed to choose a rational coating for hard alloy of VK8 grade.
PROBLEMS AND METHODS TO IMPROVE AUTOMATIC COUPLING DEVICE OF FREIGHT CARS, TAKING INTO ACCOUNT THE PECULIARITIES OF THEIR OPERATION
Authors: Filippov Viktor , Sergeyev Ivan , Pishchik Aleksandr , Kurzina Nadezhda
Published: May 2024

The problems to operate the automatic coupling device are considered, taking into account significant changes in the operating conditions of freight cars. The operation experience of freight car automatic coupling devices of domestic railways and the United States of America is analyzed; common problematic issues are identified. Approaches to the study of modes of longitudinal-dynamic impact of cars are defined, a simplified model is given. There is a need to change the design of the automatic coupling device of freight cars by using two sequentially arranged blocks with working elements, as well as improving the properties of the working material of absorbing devices, especially in operating conditions over a wide temperature range.
IMPROVEMENT OF THE REPAIR SYSTEM AND MAINTENANCE OF LONG-DISTANCE PASSENGER CARS
Authors: Shinkaruk Andrey
Published: May 2024

The existing systems of maintenance and scheduled preventive maintenance of passenger rolling stock used for long-distance passenger traffic with speeds up to 140 km/h are considered. Promising areas for their improvement are identified. A combined repair system is proposed, which provides a uniform approach of the rolling stock to the position of a single technical audit and scheduled preventive maintenance without taking into account its mileage. The replacement of the element base, when the mileage criteria are met, is carried out on repair and equipment tracks or specially equipped positions during the technical preparation of the rolling stock at the initial point. The proposed system, in comparison with existing ones, reduces the need for depot repairs; the cost of carrying out scheduled repairs of cars, the time spent by cars in an idle fleet, and also provides opportunities for additional operation of the car at the operational stage of the life cycle. Also, the proposed system allows regulating the frequency of the element base replacement of passenger cars with a designated service life of 40 years, including them in the mandatory requirements for the necessary periodic replacement during capital repairs of the car every 5 years.
COMPARATIVE ESTIMATES OF PROMISING NIPPLE DRINKERS FOR POULTRY
Authors: Saitov Viktor , Allakhverdiyev Bahruz
Published: May 2024

The problem of watering poultry with water is analyzed. The aim of the study is to choose the design of a nipple drinker for poultry when they are with cage kept. In accordance with this, in order to develop a modern nipple drinker for poultry that meets the sanitary and technical requirements of the poultry housing, a comparative analysis of existing nipple drinker designs is carried out. A nipple drinker for poultry of cage keeping is developed. The tests conducted on broilers show that the nipple drinker meets the physiological needs of poultry in water and is reliable in operation while reducing the cost of its preventive maintenance. The nipple drinker has a low water consumption during batch feeding, is hygienic in use, improves the sanitary condition of the poultry room, increases the live weight of broilers by 3...5%.
The developed nipple drinker for poultry in comparison with its closest analogues has a simple design, low labor intensity of manufacture, the possibility of self-purification from salt deposits on the inner surface of the device regulating the flow of water, increases reliability in operation and reduces water losses by its portion supply, improves the sanitary condition of the room for keeping poultry.
Federalismo regresivo: Tensiones entre distribución territorial e interpersonal del ingreso en la Argentina
Authors: Gervasoni Carlos
Published: May 2024

Se enfatizan tres características del federalismo argentino que conspiran contra la equidad distributiva. En primer lugar, nuestro federalismo y su muy alto malapportionment legislativo producen incentivos para que la agenda distributiva esté dominada por la distribución territorial de los recursos fiscales entre los gobiernos nacional y subnacionales, más que por la distribución interpersonal del ingreso. En segundo lugar, las desigualdades territoriales producidas por la «lotería geológica» (distribución geográfica de los recursos naturales) es reforzada en nuestro país por la asignación del total de las regalías a las (típicamente ricas) provincias productoras. Finalmente, la propia ley de coparticipación manda que algunas provincias ricas reciban niveles mucho más altos de transferencias federales por habitantes que otras mucho más pobres. Estos aspectos regresivos de nuestro federalismo probablemente expliquen en parte que, luego de largos años de gobiernos supuestamente comprometidos con la igualdad socioeconómica, del enorme aumento del tamaño del sector público argentino entre mediados de los 2000 y mediados de la década de 2010, y de la implementación de algunas políticas públicas efectivamente igualadoras, el país llegue a su cuarta década de democracia con un nivel de desigualdad peor que el que tenía al inicio del actual período democrático.
Tensión entre la organización federal argentina y los derechos humanos
Authors: Blogna Tistuzza Sergio Hernán
Published: May 2024

Los derechos humanos constituyen un repertorio de libertades y derechos inherentes a cada uno de los seres humanos, sobre la base de su igualdad y dignidad personal y social. En 1992, la Corte Suprema de Justicia de la Nación definió que el derecho internacional y el derecho nacional integran un mismo ordenamiento jurídico, instaurando una postura monista. En 1994, la reforma de la Constitución Nacional confirmó esa posición y otorgó jerarquía constitucional a las diversas normas en materia de derechos humanos. Se configuró, en consecuencia, un piso mínimo de derechos para todas las personas. Los Estados subnacionales se encontraron con un conjunto amplio de nuevas obligaciones a las que respetar, sumado a los nuevos servicios que recibió por el proceso de descentralización de la Reforma del Estado. Todo ello sin nuevos recursos o fuentes de financiamiento para cumplir con los nuevos gastos. Se produce, entonces, un «estrangulamiento» a nivel subnacional, producto de la presión para satisfacer estas nuevas exigencias de los tratados internacionales. Este proceso constituyó una transformación del federalismo plural centralizado, que Argentina había adoptado en el siglo XIX.
Redes partidarias y elecciones municipales en la provincia de Santiago del Estero, Argentina (2006-2022)
Authors: Campos Hernán
Published: May 2024

Se estudió la interacción entre el campo político provincial y las redes partidarias municipales (2006-2022) en la provincia de Santiago del Estero, en un contexto de autonomía relativa de los liderazgos provinciales. La investigación muestra que el oficialismo provincial en Santiago del Estero construye predominio político; sin embargo, convive con un proceso de disputa política electoral a nivel municipal. En el caso estudiado, el Frente Cívico, predominante a nivel provincial, funciona a nivel municipal como sistema que contiene oficialismo y oposición. Los hallazgos fueron construidos por descripciones de las prácticas de las redes partidarias, de entrevistas, registros de observación y trabajo de archivo en diarios provinciales para las elecciones municipales de los años 2006, 2010, 2014, 2018, 2022.