bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultrastructural features of oral discoid lupus erythematosus
Authors: Schiødt M. , Andersen L.
Published: March 2023

Tissue from buccal and labial mucosal lesions of discoid lupus erythematosus (DLE) was studied in the electron microscope. The material comprised 10 patients, 7 of whom presented skin lesions as well. The epithelium showed a change in differentiation pattern from nonkeratinizing to keratinizing epithelium. Civatte bodies (filamentous bodies) were present intercellularly in the basal and suprabasal cell layers, and in the juxta-epithelial lamina propria. Dyskeratotic cells, suggesting immature stages of Civatte bodies, were recorded in the lower stratae of the epithelium. The epithelium-connective tissue interface was abnormal, presenting detachments, gaps and multiplications of the lamina densa. Cytoplasmic tubular structures were observed in epithelial and endothelial cells, as well as in fibroblasts, lymphocytes and macrophages. The oral tissue changes recorded were common in both groups of patients studied, i.e. with and without skin lesions, and similar to earlier reported changes of DLE skin lesions.
Epidermal nuclear IgG deposition in normal skin: characterization by anti-ribonucleoprotein IgG-Fab fragments
Authors: Claudy AL , Salandre J , Claudy D
Published: March 2023

Epidermal nuclear IgG deposition in clinically normal skin may occur in patients with scleroderma or scleroderma-like features. In order to evaluate the mechanisms of the fixation, Fab fragments of anti-RNP IgG antibodies, obtained after papain digestion, were incubated for increasing times with various substrates: human skin, human mononuclear cells, cultured human fibroblasts and rabbit lip. Our results showed that anit-RNP IgG-Fab fragments could penetrate most of the living cells of human skin and rabbit lip and, to a lesser degree, mononuclear cells and poorly cultured fibroblasts. No ability to fix was found either with anti-RNP IgG-Fe fragments or with anti-nDNA/DNP IgG-Fab. It was concluded that anti-RNP IgG could penetrate viable epidermal and non-epidermal cells and that surface Fe receptors must play a minor role in the cellular penetration of antibodies.
Immunofluorescence studies on complement components in the hair follicles of normal scalp and of scalp affected by alopecia areata
Authors: Igarashi R , Morohashi M , Takeuchi S , Sato Y
Published: March 2023

The deposition of complement components (Clq, C4 C3, C5 and C9) and properdin in scalp hair follicles was examined by the immunofluorescence method in patients with alopecia areata and in normal subjects. C3, C5 and C9 were found deposited there. The complement deposition was most frequent in the case of C3 and less frequent in C9 and C5. There was no difference regarding deposition between normal subjects and patients with alopecia areata. No deposition of Clq, C4 or properdin was observed in the hair follicles of the scalp. These findings suggest a relationship between the hair cycle and the activity of C3 and its late complement components in the scalp.
Pharmacokinetic comparison of seven 8-methoxypsoralen brands
Authors: Menne T , Andersen KE , Larsen E , Solgaard P
Published: March 2023

The pharmacokinetics of seven 8-MOP brands were evaluated in 7 volunteers using an incomplete bloc design. After a single oral dose the 8-MOP plasma level was followed for 3 hours. The plasma concentration was measured with a gas chromatographic - mass spectrometric method, using an isotopic dilution technique. The different brands could be divided into three groups. Two gave a high maximum concentration, four a medium, and one a low concentration. The large interbrand variation observed in this study can explain the variations in the results of the treatment and the differing numbers of joules required to clear the patients in various PUVA centers.
Pronounced formation of 5-OH-dopa at enzymatic oxidation of DOPA in the presence of ascorbic acid
Authors: Hansson C , Rorsman H , Rosengren E
Published: March 2023

The recently discovered intermediate product in melanin formation, 5-OH-dopa, is formed in large amounts when dopa is oxidized by tyrosinase in the presence of ascorbic acid.
Focal contact sensitivity to nitrogen mustard in lesions of cutaneous T-cell lymphoma (mycosis fungoides)
Authors: Shelley WB
Published: March 2023

A report is presented on a patient with mycosis fungoides who developed a remarkable focal contact sensitivity to topically applied nitrogen mustard in aqueous solution (1/5000). Although the nitrogen mustard was applied over the entire skin surface, repeated challenge demonstrated that the eczematous contact dermatitis reaction was limited precisely to the areas of clinically identifiable mycosis fungoides. The surrounding normal skin showed no response. The basis for the surprising focal induction and localization of contact dermatitis is not known but might reflect the presence of a clone of malignant T-lymphocytes which became specifically sensitized to the nitrogen mustard.
Induction of tinea cruris by topical nitrogen mustard and by systemic chemotherapy
Authors: Shelley WB
Published: March 2023

The present report describes the rapid clinical appearance of superficial fungus infections after the initiation of topical nitrogen mustard treatment in one patient and a short course of systemic cytotoxic drugs in another.
A spontaneously healing collodion baby: a light and electron microscopical study
Authors: Frenk E
Published: March 2023

Skin biopsies from a collodion baby, spontaneously healing at the end of the third month, were taken on the 1st and 15th day after delivery and examined by light and electron microscopy. The microscopical features observed were different from those known to occur in collodion babies evolving into lamellar ichthyosis and may contribute to a more precise, early diagnosis and prognosis of this heterogeneous neonatal syndrome.
Itch following photochemotherapy for psoriasis
Authors: Rogers S , Marks J , Shuster S
Published: March 2023

Itch was measured quantitatively as nocturnal scratch in 12 patients with psoriasis treated with 8-methoxypsoralen and UVA and in 7 treated with dithranol. Three of those treated with PUVA showed an increase in nocturnal limb movement which was mostly due to itch but partly due to restlessness. There was little change in nocturnal limb movement in patients treated with dithranol.
The lichen planus like and sclerotic phases of the graft versus host disease in man: an ultrastructural study of six cases
Authors: Janin-Mercier A , Saurat JH , Bourges M , Sohier J , Jean LD , Gluckman E
Published: March 2023

Skin biopsies from 6 patients with chronic graft-versus-host disease (GVHD) were studied ultrastructurally. The 6 patients experienced an early lichenoid phase 65-135 days after the graft and 3 of them progressed to a late sclerotic phase 200-340 days after the grafting Damage to the basal membrane and to the keratinocytes of the basal layer and low spinous layers, and presence of epidermal regenerative cells were features common to the lichenoid phase of chronic GVHD and idiopathic lichen planus. The late sclerotic phase of GVHD with persistence of basal cell injury, normal periodicity and structure of the collagen fibres and numerous active fibroblasts in the upper third of the dermis were findings that distinguished GVHD from scleroderma. Satellite cell necrosis, i.e. lymphocyte satellites of necrotic keratinocyte, was observed in the two phases of chronic GVHD. Thus at the ultrastructural level the early phase of chronic GVHD mimics lichen planus, but the late sclerotic phase is distinct from scleroderma.
Studies on pruritogenic and histamine-releasing effects of some putative peptide neurotransmitters
Authors: Fjellner B , Hägermark O
Published: March 2023

Pruritus, whealing and axon-reflex erythema appeared in human skin after intradermal injection of (i) several peptides with a putative transmitter function, i.e. vasoactive intestinal polypeptide (VIP) (10(-7)--10(-4) M), [Gln4]-neurotensin (10(-7)--10(-4) M), neurotensin (10(-5)--10(-4) M) and secretin (10(-5)--10(-4) M), which were compared with substance P (10(-7)--10(-5) M) previously shown to be one of the most potent histamine liberators when administered intradermally in humans; (ii) the basic polypeptide protamine (10(-7)--10(-4) M); and (iii) histamine (0.3-10 micrograms/ml) and the histamine liberator compound 48/80 (0.3-10 micrograms/ml). The reactions were inhibited in a dose-related manner by the antihistamine mepyramine, indicating that the peptide-induced responses were mediated by released histamine. This was further confirmed by the histamine release observed when the peptides were incubated with rat peritoneal mast cells. In human skin, VIP was more potent than the other neuropeptides and had roughly the same potency as substance P. The two adjacent basic amino-acid residues and the amide substitution of the terminal C-group of VIP, in addition to its strong net basic charge, may explain its potency as a histamine releaser.
One-week treatment of chlamydia-positive urethritis with doxycycline and tetracycline chloride in males
Authors: Juvakoski T , Lauharanta J , Kanerva L , Lassus A
Published: March 2023

65 patients with chlamydia-positive urethritis were treated with doxycycline and 59 with tetracycline chloride 1 g/day for one week. All steady sexual partners of these patients were treated with the same regimen during the same period. At control visits 2 and 3 weeks after the beginning of the treatment, all re-examined doxycycline-treated patients and all except 4 tetracycline-treated patients showed clinical cure and were free from signs of urethritis in the microscopical examination of Gram-stained smears from the urethra. Isolation of C. trachomatis was positive in 7 of the doxycycline-treated and 10 of the tetracycline-treated patients at the first control visit and in one more tetracycline-treated patient at the second control visit. The study stresses the importance of attempts to isolate C. trachomatis in cases without clinical or microscopical evidence of nongonococcal urethritis at control visits after short-term treatment with tetracyclines. The present investigation indicates that this is true also in cases in which all steady sexual partners are treated simultaneously.
Sulphhydryl and disulphide stainings of amyloid: a comparison with hyaline body
Authors: Danno K , Horio T
Published: March 2023

Histochemical staining for sulphhydryl (-SH) groups and disulphide (S-S) bonds was undertaken in 10 cases of cutaneous amyloidosis using the new fluorescent thiol reagent. A weak S-S fluorescence (but not -SH) was detected in dermal amyloid, suggesting that cross-linking of -SH groups may occur in amyloidogenesis. Since in normal skin S-S bonds were stained only in the horny layer and negligibly in the dermis, our findings seem to support the view that amyloid is derived at least partially from epidermal cells.
Anti-Ia-reactive cells in mycosis fungoides: a study of skin biopsies, single epidermal cells and circulating T lymphocytes
Authors: Tjernlund UM , Scheynius A , Kabelitz D , Klareskog L
Published: March 2023

Skin sections, epidermal cells in suspension and circulating T lymphocytes were investigated for the presence of Ia-like antigens in a group of patients with the cutaneous T-cell lymphoma mycosis fungoides (MF) and in healthy controls. Highly purified anti-Ia antibodies were used in indirect immunofluorescence, indirect peroxidase and peroxidase-antiperoxidase techniques. Allogeneic and autologous mixed leukocyte reaction tests with epidermal cells from MF lesions as stimulator cells were also performed. The majority of the dermal lympho-histiocytes and mononuclear cells in the epidermal Pautrier microabscesses expressed Ia-like antigens. So also did a greater proportion of circulating T lymphocytes than in the controls. In some MF patients a high percentage of single epidermal cells of non-lymphoid character also reacted with the antibodies. The possible significance of the present findings for the pathogenesis of MF is discussed.
ELISA-determined serological reactivity against purified trichophytin in dermatophytosis
Authors: Kaaman T , Von Stedingk LV , Von Stedingk M , Wasserman J
Published: March 2023

Serological activity in 62 patients wih dermatophytosis was investigated using purified trichophytin preparation as antigen (produced by the ethylene glycol method). Antibodies of IgG and IgM classes were determined by means of ef enzyme linked immunosorbent assay (ELISA). In comparison with 79 controls consisting of groups of healthy blood donors and dermatological outpatients, the dermatophyte-infected patients showed a significantly higher mean IgG response to trichophytin antigen preparation. On the other hand several individual cases were low responders. In a group of 10 control children, no IgG activity against trichophytin could be demonstrated. IgM class antibodies showed no significant differences between the groups investigated. These findings indicate that differences in the amounts of antibodies of IgG class against trichophytin as measured by the ELISA method reflect differences in the degree of mycotic sensitization between groups of individuals having experienced varying degrees of exposure to dermatophytes. Nevertheless, the determination of IgG antibodies in dermatophytosis seems to be of limited clinical value.
The prevalence of psoriasis in Denmark
Authors: Brandrup F , Green A
Published: March 2023

A representative random sample comprising approximately 4000 Danes, 16-99 years old, were questioned as to present or previous psoriasis eruption by non-medical, professional interviewers. Based on the information obtained, the point prevalence for men was 4.2%, for women 3.3%. 88% of those who believed themselves to be suffering from psoriasis stated that they had been treated by doctors for psoriasis and 71% by dermatologists and/or dermatological departments. The difference found between men and women is not statistically significant. The actual prevalence has been adjusted according to an estimated overcalculation of some 25% based on the number of false-positive answers to questionnaires in a twin study. The prevalence for men is thus adjusted to 3.2% and for women to 2.5%. The number of adult psoriatics in Denmark is estimated at approximately 113,000, of whom 71,000 suffer from mild psoriasis and 42,000 from more severe psoriasis.
The course of culture of human keratinocytes: increase of heat-labile fraction of glucose-6-phosphate dehydrogenase
Authors: Kitano Y , Okada N
Published: March 2023

Human epidermal keratinocytes in cell culture are unique in reorganizing the formation of a stratified cellular sheet and performing terminal differentiation. The course of keratinocytes in culture was delineated over 50 days in the primary culture. The rapid increase in total DNA content commencing 2 weeks after plating corresponded to the appearance of small polygonal keratinocytes in groups. The DNA content reached its maximum after 25 days of cultivation, decreasing gradually thereafter. The protein content increase slowly until 16 to 18 days of cultivation, and then increased rapidly, though slightly behind the rapid increase in DNA. The maximum value of protein content was reached at 32 days, after which the value decreased when the keratinized cells of the uppermost layer began to detach. The heat-labile fraction of glucose-6-phosphate dehydrogenase was increased in 33- and 43-day cultures, when the DNA content was decreasing.
Epinephrine-induced cyclic AMP accumulation in the psoriatic epidermis
Authors: Iizuka H , Umeda K , Koizumi H , Aoyagi T , Miura Y
Published: March 2023

Although there are many reports concerning different beta-adrenergic responsiveness in involved and uninvolved skin of psoriasis, previous experiments have been done mainly by using keratome-sliced skin, which contains unknown amounts of stratum corneum, dermis, skin appendages, etc. In order to determine the effect of epinephrine on the cyclic AMP level of ´pure´ epidermis in psoriasis, a microdissection technique was employed. Basal levels of cyclic AMP in the involved epidermis were slightly higher than in the uninvolved epidermis (involved 1.9 +/- 0.3 pmoles/mg dry weight; uninvolved 1.3 +/- 0.3 pmoles/mg d.w.). This difference was not statistically significant (p greater than 0.1). The response to epinephrine by the involved epidermis (8.4 +/- 1.0 pmoles/mg d.w.) was much lower than that in the uninvolved epidermis (23.3 +/- 4.3 pmoles/mg d.w.). The difference was statistically highly significant (p less than 0.005). Our data show that psoriatic involved epidermis per se had a reduced beta-adrenergic responsiveness, which might be significantly involved in the pathophysiology of psoriasis.
Lichen planus: a distinct entity from lupus erythematosus
Authors: Potts ED , Rowell NR
Published: March 2023

Thirty-five patients with classical lichen planus (LP) were extensively investigated with special reference to immunohistological changes and histocompatibility (HLA) typing. There was no evidence of lupus erythematosus (LE) in any patient, although one patient with LP and eczema had an elevated titre of antinuclear factor. There was no increased incidence of any HLA type--in particular HLA-B7 and HLA-B8--known to be associated with LE. The results suggest that LE and LP are separate disorders.
Serological classification of Neisseria gonorrhoeae by co-agglutination: a study of serological patterns in two geographical areas of Sweden
Authors: Bygdeman S , Danielsson D , Sandström E
Published: March 2023

Gonococcal strains, isolated in two different geographical areas of central Sweden (Stockholm and Orebro County) during two corresponding time periods, were subjected to serogrouping by the co-agglutination method with reagents covering the previously described serogroups W I, W II and W III. All strains tested could be grouped. Significant differences were found between the two geographical areas studied. Isolates from different sites on one and the same patient and strains from contact pairs gave identical results. The test results were reproducible, when the strains were exchanged between the two participating laboratories. The reagents distinguished Neisseria gonorrhoeae from other Neisseria species and other oxidase-positive bacteria. The potential of serogrouping gonococci for epidemiological studies by means of the co-agglutination method is discussed.
Spontaneous cell-mediated cytotoxicity (SCMC) in patients with alopecia universalis
Authors: Gu SQ , Ros AM , Thyresson N , Wasserman J
Published: March 2023

The spontaneous cell-mediated cytotoxicity (SCMC) of unfractionated lymphocytes was determined in 5 patients with alopecia universalis (AU). The target cells used were K562 and Chang cell lines. All patients had an increased SCMC as compared with age- and sex-matched donors. The results indicate that SCMC against K562 cells is more pronounced than that against Chang cells.
Hair changes due to zinc deficiency in a case of sucrose malabsorption
Authors: Weismann K , Hagdrup HK
Published: March 2023

A 7-year-old girl suffering from chronic diarrhoea due to sucrase deficiency was referred because of poor hair growth. Her scalp hair had a poor, colourless appearance and was much thinned in the occipital region. Her skin was dry, but otherwise normal. P-zinc was low (7.9 mumol/l), whereas P-albumin was normal. Oral zinc therapy, 40 mg daily, had a marked beneficial effect on her scalp hair, eyebrows and eyelashes, which became thicker and pigmented. Beau lines appeared on thumb-nails and 4th left finger-nail. A rise in P-zinc and S-alkaline phosphatase levels was observed during the zinc supplementation. Microscopic examination of her poor scalp hair, using polarized light, revealed well-defined abnormalities of the hair shafts, as reported by others in a case of acrodermatitis enteropathica: 1) a marked individual variation in diameter, 2) narrowing often associated with waving or sharp bending and broken ends, 3) striation with a tendency to trichonodosis. Such changes were absent in the pigmented hair appearing after the start of zinc therapy.
Infectious mononucleosis (glandular fever) complicated by cold agglutinins, cold urticaria and leg ulceration
Authors: Barth JH
Published: March 2023

Abstract not available
The atopic thigh: a "starting-school´ symptom?
Authors: Fredriksson T , Faergemann J
Published: March 2023

In a retrospective survey of 1112 patients with atopic dermatitis we found that the age of onset of lesions localized to the lower gluteal and posterior femoral regions reached its peak at the age of 7 to 8 years. We speculated that this is due to sweat retention caused by prolonged sitting when these predisposed individuals start school.
Sclerosing lymphangitis of the penis: a possible chlamydia aetiology
Authors: Kristensen JK , Scheibel J
Published: March 2023

Abstract not available
Isolation of Chlamydia trachomatis from the urethra and from prostatic fluid in men with signs and symptoms of acute urethritis
Authors: Nilsson S , Johannisson G , Lycke E
Published: March 2023

Chlamydia trachomatis was isolated from the urethra in 71 of 275 men primarily attending the outpatient clinic of the Department of Urology because of symptoms of acute urethritis, and with more than four polymorphonuclear leukocytes in each of at least five fields of the swabbed urethral exudate (x1000). C. trachomatis was isolated from 34 of 48 men below 26 years of age, while only 37 of the 227 men aged 26 years or older harboured chlamydial infection. C. trachomatis was isolated from the prostatic secretion of 26 men with acute urethritis and more than 20 polymorphonuclear leukocytes in 10 or more random fields (x450) in the stripped prostatic fluid, suggesting a positive correlation between chlamydial infection and sub-acute silent prostatitis. Among 70 men with C. trachomatis isolated from the urethra, the organism had disappeared at re-examination within 10 days in 19 (27%). Such a disappearance was found in only one of 26 men (4%) in whom C. trachomatis had been isolated not only from the urethra but also from stripped prostatic fluid. Four weeks after two treatment cycles of lymecycline 300 mg twice daily for 7 days with an interval of 10 days, C. trachomatis was but isolated in any urethral specimen, nor from the expressed prostatic fluid.
Association of LLA-DR3 and herpes gestationis
Authors: Ferrando J , Ercilla G , Arriaga F , Bordas X , Vives J , Mascaro JM
Published: March 2023

Abstract not available
Human leukocyte mobilization and morphology in nickel contact allergy using a skin chamber technique
Authors: Lerche A , Bisgaard H , Christensen JD , Søndergaard J
Published: March 2023

An improved skin chamber technique has been devised and used for quantitative evaluation of the leukocyte mobilization rate (LMR). The method was applied in 10 nickel-hypersensitive patients exposed to nickel sulphate. Each patient served as his own control and for additional control purpose, 5 healthy individuals without nickel hypersensitivity were studied. The kinetics of the mobilized leukocytes were followed over a 48-hour period. After an initial lag phase of 2-4 hours, maximum migration was observed from the 24th to the 48th hour, with a wide interindividual variability in the number of mobilized cells at the time of maximum LMR response. The median cumulative leukocyte count was 1.412 x 10(6) leukocytes/cm2/48 h. In the same period a statistically significant increase in the basophils for all the nickel allergic patients was observed. In 8 out of 10 patients a statistically significant effect upon the lymphocytes could be demonstrated. Six of these 8 patients had an increased lymphocyte mobilization. Throughout the period the neutrophil granulocytes were the dominant cell type, although the number decreased as the number of basophils and lymphocytes increased. The chamber technique is a valuable means for quantitative evaluation of leukocyte mobilization and morphology in skin exudates during exposure to an allergen in delayed hypersensitivity reactions.
Trioxsalen bath plus UVA treatment of psoriasis. Plasma concentration of the drug and clinical results
Authors: Salo OP , Lassus A , Taskinen J
Published: March 2023

Forty-five patients with psoriasis were treated with trioxsalen bath plus UVA. Good or excellent results were obtained in 34 (67%) of the 51 treatments. Trioxsalen plasma concentrations were determined at different stages of the treatment in 10 patients 1 hour after trioxsalen bath, and in 11 patients undergoing treatment for vitiligo 2 hours after ingestion of 0.6 mg trioxsalen per kilogram body weight. The determinations were performed using the glass capillary, gas chromatography, mass spectrometry method, reaching a sensitivity of greater than or equal to 25 pg/ml. The trioxsalen plasma concentrations varied between 12.5 and 0.27 ng/ml after oral ingestion and between approximately 9 ng/ml and less than 25 pg/ml after bath application.
The isomorphic (Koebner) phenomenon in cutaneous mastocytosis
Authors: Rampen F , Westerhof W
Published: March 2023

Abstract not available
Clear cell acanthoma: not of sweat gland origin
Authors: Penneys NS , Nadji M , Ziegels-Weissman J
Published: March 2023

Abstract not available
Elastotic material and elastic fibers in aged skin: an ultrastructural study with conventional and tannic acid stain
Authors: Tsuji T , Hamada T
Published: March 2023

Elastotic material and aged elastic fibers were studied with an electron microscopy, using both conventional and tannic acid stain. (1) A relatively large part of the fibrous form, and a lesser part of the amorphous form stained positive with the tannic acid stain. (2) Aged elastic fibers showed some age-related findings with both conventional and tannic acid staining. It is suggested that the elastotic material originates from the elastic fibers and progresses from the fibrous to the amorphous form.
The influence of sex hormones on acne
Authors: Förström L
Published: March 2023

No abstract available
Acne:possibilitiesandprobabilities.
Authors: Shuster Sam
Published: March 2023

No abstract available
Traditional topical treatment of acne
Authors: Hjort N
Published: March 2023

Few studies of topical treatment in acne stand up to modern scientific requirements, and several of those which do suggest that some modalities make acne worse rather than better. There is evidence that sulphur, soap, and light treatment prolong the course of illness. This also applies to some components of the vehicles used for acne medicaments. Fortunately, traditional treatment can be abandoned in favour of the superior benzoyl peroxide and retinoic acid.
Topical vitamin-A-acid in acne
Authors: Zachariae Hugh
Published: March 2023

No abstract available
General considerations by a clinical bacteriologist regarding antibiotic therapy in acne
Authors: Holm SE , Burman LG.
Published: March 2023

No abstract available
Oral zinc in acne.
Authors: Michaëlsson G.
Published: March 2023

No abstract available
The natural history of atopic eczema
Authors: Vickers C.F. H.
Published: March 2023

A long-term follow-up study of 2 000 children with atopic ecxema for from two to twenty-one years: clearance rates, pubertal recurrence rates and factors with or without prognostic significance are reported. Late onset "reversed pattern" and possibly social factors are adverse features, whilst early onset, seborrhoeic pattern and male sex are favourable prognostic signs. These results are based on a follow-up rate better than 90% and are the first results in the literature of a prospecitivisurvey of this disease.
Effects of histamine receptor antagonists on histamine-induced responses in human skin
Authors: Hägermark Östen , Strandberg Kjell , Grönneberg Reidar
Published: March 2023

Abstract is not available
Bacteriology of atopic dermatitls
Authors: Aly Raza
Published: March 2023

The aerobic bacterial flora of dermatitic skin. uninvolved skin, and the anterior nares of subjects with atopic eczema was investigated. A general comparison of the bacterial flora of subjects with atopic eczema, psoriasis and from a normal population was made. The incidence of Staphylococcus aureus in atopics was: 93%, 76% and 79% in the lesions, non-involved skin and the anterior nares respectively. For psoriatics the incidence was: 20% on the plaqucs, 13% on the uninvolved skin and 30% in the anterior nares.1 The occurrence of S. aureus was very low on the skin of normal population (< 10%), S. aureus was the predominant organism in the lesion of atopics and coagulase?negative staphylococci were the major bacteria in the psoriatic plaques and on the skin or the normal population. Fifty eight percent of the S. aureus strains isolated from atopics belonged to group 3 and 38% were nontypable. S. aureus strains belonging to phage groups 2 and 4 were not detected.
Adrenoceptor binding studies with [3H]dihydroalprenolol and [3H]dihydroergocryptine on membranes of lymphocytes from patients with a topic disease
Authors: Szentivanyi A. , Heim O. , Schultze P. , Szentivanyi J.
Published: March 2023

Using [3H]dihydroalprenolol (DHA) and [3H]dihydroergocryptine (DHE), that is specific radioligands for the measurement of beta- and alpha-adrenoceptors, respectively, binding studies were performed on membranes of lymphocytes from patients with atopic dermatitis, patients with non?atopic skin diseases, and normal individuals. A shift in the numbers of receptors from beta- to alpha was found in the lymphocytic membranes from patients with atopic dermatitis but not in the other 2 groups. That this shift cannot be due to possible variations in the proportion of lymphocyte subpopulations was demonstrated by the lack of difference in alpha and beta?receptor numbers between B and T lymphocytes, indicating that the adrenoceptor shift is intrinsic to the disease-state itself. Taken together with similar findings in lung tissue and lymphocytes from patients with reversible obstructive airways disease (asthma) the observations suggest that the constitutional basis of atopy may lie in an inherited or acquired adrenergic abnormality causcd by a shift in available receptor numbers from beta- to alpha-adrenoceptors.
Computer analysis of nocturnal scratch in atopic dermatitis
Authors: Aoki Toshiyuki , Kushimoto Higashi , Kobayashi Eijiro , Ogushi Yoichi
Published: March 2023

Scratch behavior was monitored with a paper strain gauge attached to the dorsum of the hand and an amplifier. The all-night recording was subsequently analysed every 60 sec with a specially devised computer system and the duration of scratching and the time(s) of its occurrence were printed out. This technique was applied in 10 patients with moderate or severe atopic dermatitis, 5 with generalized eczema and 5 non-itchy subjects. It was found that scratching occurred in cluster(s) or in an isolated form in both itchy and non-itchy subjects. Marked clustering of scratch behaviour was noted only in itchy subjects. No specific difference was observed in scratch patterns of atopic dermatitis vis-?-vis generalized eczema. Total scratch time of the right and left hands during the night ranged between approx. 1 and 5 thousand sec in itchy patients and between 1 and 5 hundred sec in non-itchy subjects. The ratio of the total scratch time to the recording time in atopic dermatitis did not differ significantly from that in generalized eczema. No correlation was observed between the duration of scratch and serum lgE level.
Chemotaxls inhibition by plasma from patients with atopic dermatitis
Authors: Hanifin Jon M. , Rogge L. Janet , Bauman Richard H.
Published: March 2023

We previously reported depressed polymorphonuclear leukocyte and monocyte chemotaxis in patients with severe atopic dermatitis. The degree of impairment roughly correlated with the disease severity and chemotaxis was noted to improve rapidly with clinical remissions. This rapid improvement suggested the presence of a short-lived plasma inhibitor of leukocyte function. We used a radio?labeled PMN chemotaxis assay to assess plasma effect on migration. PMN?s were incubated in plasmas from patients with varying degrees of atopic dermatitis then washed and assessed for migration toward endotoxin-stimulated serum attractant. lnhibitory effect varied widely and correlated directly with clinical extent and severity of dermatitis. Serial studies on individual patients showed lessening of plasma inhibitory activity during remissions. PMN?s from patients with atopic dermatitis showed improved migration after incubation in normal plasma. There was no evidence for circulating chemoattractants nor chemotactic factor inactivators. There appears to be a circulating inhibitor of chemotaxis present in plasma during acute flares of atopic dermatitis; the molecular nature of the inhibitor remains to be elucidated.
Common immunochemistry in atopic dermatitis and bronchial asthma
Authors: Aas Kjell
Published: March 2023

Atopic dermatitis and bronchial asthma are closely associated with respect to hereditary factors, epidemiology and occurrence in the same individuals. Both depend on more or less common genetic and environmental traits. Both are typical multifactorial diseases. They have also much in common as regards the complex immunological and chemical mechanisms involved. This becomes particularly evident when comparable subgroups of patients with either atopic dermatitis and bronchial asthma are investigated.
Tuberculin reaction in atopic dermatitis
Authors: Uehara Masami
Published: March 2023

Serial examinations of tuberculin reactivity were performed in 16 patients with atopic dcrmatitis (AD) and in 14 patients with allergic contact dermatitis. Transient suppression of already established tuberculin reactivity was seen in the contact dermatitis patients. Tuberculin reactivity in the AD patients also fluctuated with the condition of the dermatitis. When the dermatitis was active, there was diminished tuberculin reactivity. During remission of the dermatitis, however, a significam increase in tuberculin reactivity occurred. It is suggested that, in some patients with AD, the suppressed cell-mediated immunity may be secondary to the eczematous inflammatory process.
Class and subclass distribution of specific antibodies to codfish allergen in a patient with atopic allergy
Authors: Lea T. , Braathen L.R. , Moen T.
Published: March 2023

Using an indirect ELlSA technique together wilh rabbit antisera specific for human immunoglobulin classes and lgG subclasses, an estimate was made of the contribution of immunoglobulin classes and subclasses to the overall antibody response against codfish allergen in serum from a patient allergic to codfish. Allergen-specific antibodies were found to be of immunoglobulin classes lgM, lgD and lgE and the subclasses IgG1, lgG3 and IgG4. No antibodies of lgA class or lgG2 subclass were present. High levels of lgG3 and lgD were found.
High frequency of hereditary complement defects in association with atopic diseases
Authors: Giannetti A.
Published: March 2023

No abstract available
Immunological, histological and electron-microscopical lnvestigations of the gut in atopic dermatitis
Authors: Braathen Lasse R. , Baklien Kåre , Hovig Torstein , Fausa Olav , Brandtzaeg Per
Published: March 2023

Jejunal biopsy specimcns were obtained from ten patients with severe atopic dermatitis and 15 controls. Light microscopical examination of hematoxylin-eosin stained sections showed normal condition in all atopic patients and intra-epithelial lymphocyte counts did not differ significantly from counts in controls. Scanning electron-microscopical examination demonstrated minor mucosal changes in five of the atopic patients. Immunohistochemical studies did not reveal any significant changes in the class proportions and numbers or jejunal immunoglobulin-producing cells.
Results of food testing in atopic dermatitis
Authors: Hannuksela Matti
Published: March 2023

Skin testing to find food allergy in atopic dermatitis is recommcnded from the age of 4 months up the early adulthood. Scratch, scratch-chamber, prick and intra?cutancous tests may be used. In order to obtain optimal benefit from skin testing, both commercial extracts and fresh foodstuffs must be used. Extracts of protein-rich foods. such as fish, egg and nuts, work very well in skin tests, but fruits and vegetablas lose their allergenicity easily in the extraction process and that is why they are tested in raw state. The younger the patient the better the correlation bctween the skin test results and the challenge tests. The nature of the allergen also has a great influence on the clinical relevancy of the skin tests. Extracts of various cereals correlate for example in almost every case with skin reactivity alone and not with symptoms from ingested cereals.
Treatment of atopic dermatitis with tolerogenic doses of antigen
Authors: Morris David L.
Published: March 2023

The principles of allergic management of atopic dermatitis, with special reference to sublingual hyposensitization, are briefly elucidated.
Dietary antigen avoidance in the treatment of atopic dermatitis
Authors: Atherton D.J.
Published: March 2023

There is now good evidence that food allergy is an important aetiological factor in atopic dermatitis and that dietary antigen avoidance is a helpful form or therapy, particularly in younger children. Allergy history, prick tests and the RAST are of limited value in identifying the allergies present in individual children. A systematic practical approach to allergy diagnosis is currently under evaluation.
PROBLEMATIKA PERLINDUNGAN HUKUM TERHADAP KELOMPOK LESBIAN, GAY, BISEKSUAL, DAN TRANSGENDER (LGBT) DALAM PERSPEKTIF HAM INTERNASIONAL
Authors: Putu Dian Adnyani
Published: March 2023

LGBT or Lesbian, Gay, Bisexual, and Transgender are behaviors that are currently a hot topic of conversation in the international community. This group which symbolizes itself with the rainbow flag has different views in term of sexual orientation, sexual characteristics, gender identity, and gender expression. It is still very difficult  to accept their existence in society at large, so they often experience discrimination in the form of harassment, violence, threats, and so on, against the human rights of every human being. This article  aims to understand more deeply about how the legal protection for LGBT groups, especially legal protections from the perspective of the Universal Declaration of Human Rights. The methoed used in the preparation of this scientific article is a qualitative descriptive method, therefore the approach used is a case study and literature study (library research) through various literatures in the form of journals, websites, e-books that are in accordance with the problems raised in this scientific article. The result of the research contained in this scientific article indicate that the LGBT group, who is also a human being, has the same rights as independent individuals so that they are entitled to legal protection from all violence, torture, and thearts are not in accordance with human values
DINAMIKA HUKUM INTERNATIONAL SEBAGAI SUBSTANSI ETIKA ANTAR NEGARA DI DUNIA
Authors: Sang Made Merta Widnyana  , Komang Febrinayanti Dantes  , Si Ngurah Ardhya  , Muhamad Jodi Setianto
Published: March 2023

The purpose of this paper is to provide an understanding of International Law that is reviewed in general through research and study by experts and characteristics related to International Law with a view on the behavior and relations between countries regarding the application of International Law In the past and in times like the present that have undergone several processes of globalization that cause changes in the times and changes in the behavior of every society in the country related to aspects of International Law.Based on the results of the discussion that can be concluded that all kinds of actions and behaviors of objects and subjects in International Law is a discussion that becomes a real point in International Law ranging from Relations between States, International Organizations, Individuals, or even Companies struggling in the multinational field are things discussed and reviewed in International Law.
TINDAK PIDANA PERDAGANGAN ORANG (HUMAN TRAFFICKING) SEBAGAI TRANSNATIONAL CRIME
Authors: Kadek Novi Darmayanti  , Komang Febrinayanti Dantes  , Si Ngurah Ardhya  , Muhamad Jodi Setianto
Published: March 2023

Human trafficking is one of the transnational crimes that is a threat to global security which is one type of transnational crime coupled with illicit drug trafficking, maritime piracy, arms smuggling, money laundering, terrorism, international banking crimes and cybercrimes. The forms of trafficking in persons are divided based on the purpose of delivery, based on the victim, and based on the form of exploitation. Because of the massiveness of this crime, the United Nations formulated a protocol called the Palermo Protocol. In Indonesia, there are also special regulations regarding the criminal act of trafficking in persons, namely Law Number 21 of 2007. Although there are already laws and regulations that regulate this crime, in fact it is still not able to provide a sense of justice as well as security and comfort for victims of the crime of trafficking in persons. Other legal protections are still needed for victims of this crime.
IMPLEMENTASI HUKUM INTERNASIONAL TERHADAP PERSENGKETAAN WILAYAH KASHMIR ANTARA INDIA-PAKISTAN
Authors: Saifur Rauf  , Komang Febrinayanti Dantes  , Si Ngurah Ardhya  , Muhamad Jodi Setianto
Published: March 2023

This study aims to determine the view of international law on the dispute over the Kashmir region between India and Pakistan as a form of conflict resolution efforts. The legal research used is normative legal research or what is commonly referred to as library research with the acquisition of secondary data sourced from the internet. The results show that the status of the Kashmir region under international law is being contested because both India and Pakistan declare Kashmir as their territory. The dispute over the Kashmir region arises because of the conflict of political interest between the two countries and the unilaterally declared power of India and Pakistan. Pakistan also states that the Muslim majority, including religious factors, is an integral part of Pakistan, and India also claims that there is a Hindu community in Kashmir integrated with India. Furthermore, in order to resolve the Kashmir dispute between India and Pakistan, it must be carried out through bilateral relations between the two countries. The United Nations can grant rights to India and Pakistan over the Kashmir region according to their territorial location, so that there is no longer any reason for the two countries to fight over each other's territory. And countries that do not follow the decision could face severe penalties set by the United Nations.
IMPLEMENTASI PASAL 8 UNDANG-UNDANG NO. 1 TAHUN 1974 TENTANG PERKAWINAN TERHADAP PERKAWINAN SEDARAH (STUDI KASUS DI DESA PELAPUAN, BUSUNGBIU, KABUPATEN BULELENG)
Authors: Mahendra I Dewa Ketut Indra , Sudiatmaka Ketut , Sanjaya Dewa Bagus
Published: March 2023

Penelitian ini bertujuan untuk (1) mengetahui dan menganalisa faktor-faktor penyebab terjadinya budaya perkawinan sedarah di Desa Pelapuan, Kecamatan Busungbiu, serta (2) mengetahui dan menganalisa upaya pemerintah dalam mencegah terjadinya perkawinan sedarah yang terjadi di Desa Pelapuan, Kecamatan Busungbiu.  Jenis penelirian yang digunakan dalam penelirian ini adalah penelitian hukum empiris. Lokasi penelitian dilaksanakan di Desa Pelapuan, Kecamatan Busungbiu, Kabupaten Buleleng. Teknik pengumpulan data dengan menggunakan teknik studi dokumen, observasi dan wawancara. Teknik pengolahan dan analisis data secara kualitatif. Hasil penelitian menunjukkan bahwa (1) Faktor yang menyebabkan terjadinya perkawinan sedarah di Desa Pelapuan adalah adanya adat istiadat yang kental dari masyarakat hindu yang tidak menginginkan keturunannya untuk melaksanakan perkawinan dengan orang lain karena masalah kasta. Serta, (2) Upaya yang telah dilakukan desa adat dalam mencegah terjadinya perkawinan sedarah yang dalam hal ini adalah pemerintahan desa telah berusaha melakukan penyuluhan kepada pemangku kepentingan atau ketua kelompok masyarakat yang ada di Desa Pelapuan, Kecamatan Busungbiu, Kabupaten Buleleng tetap tidak berhasil karena masyarakat sangat menjunjung tinggi adat istiadat yang mereka percaya.
IMPLEMENTASI PASAL 43 AYAT 1 UNDANG-UNDANG NOMOR 16 TAHUN 2019 TENTANG HAK WARIS ANAK LUAR KAWIN ( STUDI KASUS DI DESA ADAT SEPANG
Authors: Ritama Komang Okta , Sudiatmaka Ketut , Setianto Muhamad Jodi
Published: March 2023

Penelitian ini bertujuan untuk (1) mengetahui dan menganalisa mengenai Hak Waris Anak Luar Kawin di Desa Adat Sepang, serta (2) mengetahui dan menganalisa implementasi Pasal 43 ayat 1  Undang-Undang Nomor 16 tahun 2019 tentang hak waris anak luar kawin di Desa Sepang. Jenis penelitian yang digunakan adalah penelitian hukum yuridis empiris, dengan 2 (dua) jenis pendekatan yaitu pendekatan peraturan perundang-undangan dan pendekatan kasus. Lokasi penelitian ini dilaksanakan di Desa Adat Sepang, Kecamatan Busungbiu, Kabupaten Buleleng. Bahan hukum yang digunakan berasal dari bahan hukum primer, sekunder dan tersier dengan teknik pengumpulan menggunakan teknik studi dokumen, observasi dan wawancara. Teknik penentuan sampel yang digunakan adalah teknik non probability sampling dengan bentuk penerapan menggunakan teknik purposive sampling. Teknik pengolahan dan analisis data dilakukan secara kualitatif dengan bentuk penerapan menggunakan model analisa hermeneutika hukum. Hasil penelitian menunjukkan bahwa (1) hak waris anak luar kawain Di Desa Adat Sepang menunjukan bahwa anak yang dilahirkan dari luar kawin tidak mendapatkan waris apapum. (2) implementasi Pasal 43 ayat 1 Undang-Undang Nomor 16 tahun 2019  tentang hak waris anak luar kawin, belum terlaksana dengan baik dan memang di Desa Adat Sepang anak yang dilahirkan dari luar kawin tidak mendapat waris dari ibu maupun keluarga ibunya
IMPLEMENTASI PRINSIP RESTORATIVE JUSTICE PADA PERKARA TINDAK PIDANA PENGANIAYAAN BIASA DI POLRES BULELENG
Authors: Dewi Ni Nyoman Ayu Pulasari , Hartono Made Sugi , Dantes Komang Febrinayanti
Published: March 2023

Penelitian ini bertujuan untuk (1) mengetahui dan menganalisa terkait implementasi prinsip restorative justice pada perkara tindak pidana penganiayaan biasa di Polres Buleleng, serta untuk (2) mengetahui dan menganalisa hambatan dan upaya Polres Buleleng dalam melaksanakan restorative justice pada perkara penganiayaan biasa. Adapun jenis penelitian yang digunakan adalah penelitian hukum empiris, dengan sifat penelitian deskriptif. Lokasi Penelitian ini dilaksanakan di Kabupaten Buleleng tepatnya di Polres Buleleng, adapun teknik yang digunakan dalam pengumpulan data ini yaitu dengan studi dokumen, observasi, dan wawancara. Teknik penentuan sampel yang digunakan adalah teknik Non Probability Sampling dan penentuan subjeknya menggunakan teknik Purposive Sampling sedangkan teknik pengolahan dan analisis data disusun secara kualitatif. Hasil penelitian menunjukan bahwa (1) implementasi prinsip restorative justice pada perkara tindak pidana penganiayaan biasa di Polres Buleleng sudah berjalan sesuai dengan prosedural berdasarkan Peraturan Kepolisian RI Nomor 8 Tahun 2021 Tentang Penanganan Tindak Pidana Berdasarkan Keadilan Restoratif. (2) Hambatan dan Upaya Polres Buleleng dalam melaksanakan restorative justice pada perkara penganiayaan biasa berasal dari masyarakat yang kurang paham mengenai adanya penyelesaian perkara dengan prinsip Restorative justice.