bluuebunny/crossref_metadata_2025 huggingface dataset:
Extended reality to assess post-stroke manual dexterity: contrasts between the classic box and block test, immersive virtual reality with controllers, with hand-tracking, and mixed-reality tests
Authors: Everard Gauthier , Burton Quentin , Van de Sype Vincent , Bibentyo Thérèse Ntabuhashe , Auvinet Edouard , Edwards Martin Gareth , Batcho Charles Sebiyo , Lejeune Thierry
Published: March 2024

Background

Recent technological advancements present promising opportunities to enhance the frequency and objectivity of functional assessments, aligning with recent stroke rehabilitation guidelines. Within this framework, we designed and adapted different manual dexterity tests in extended reality (XR), using immersive virtual reality (VR) with controllers (BBT-VR-C), immersive VR with hand-tracking (BBT-VR-HT), and mixed-reality (MD-MR).

Objective

This study primarily aimed to assess and compare the validity of the BBT-VR-C, BBT-VR-HT and MD-MR to assess post-stroke manual dexterity. Secondary objectives were to evaluate reliability, usability and to define arm kinematics measures.

Methods

A sample of 21 healthy control participants (HCP) and 21 stroke individuals with hemiparesis (IHP) completed three trials of the traditional BBT, the BBT-VR-C, BBT-VR-HT and MD-MR. Content validity of the different tests were evaluated by asking five healthcare professionals to rate the difficulty of performing each test in comparison to the traditional BBT. Convergent validity was evaluated through correlations between the scores of the traditional BBT and the XR tests. Test-retest reliability was assessed through correlations between the second and third trial and usability was assessed using the System Usability Scale (SUS). Lastly, upper limb movement smoothness (SPARC) was compared between IHP and HCP for both BBT-VR test versions.

Results

For content validity, healthcare professionals rated the BBT-VR-HT (0[0–1]) and BBT-MR (0[0–1]) as equally difficult to the traditional BBT, whereas they rated BBT-VR-C as more difficult than the traditional BBT (1[0–2]). For IHP convergent validity, the Pearson tests demonstrated larger correlations between the scores of BBT and BBT-VR-HT (r = 0.94;p < 0.001), and BBT and MD-MR (r = 0.95;p < 0.001) than BBT and BBT-VR-C (r = 0.65;p = 0.001). BBT-VR-HT and MD-MR usability were both rated as excellent, with median SUS scores of 83[57.5–91.3] and 83[53.8–92.5] respectively. Excellent reliability was found for the BBT-VR-C (ICC = 0.96;p < 0.001), BBT-VR-HT (ICC = 0.96;p < 0.001) and BBT-MR (ICC = 0.99;p < 0.001). The usability of the BBT-VR-C was rated as good with a median SUS of 70[43.8–83.8]. Upper limb movements of HCP were significantly smoother than for IHP when completing either the BBT-VR-C (t = 2.05;p = 0.043) and the BBT-VR-HT (t = 5.21;p < 0.001).

Conclusion

The different XR manual tests are valid, short-term reliable and usable tools to assess post-stroke manual dexterity.

Trial registration

https://clinicaltrials.gov/ct2/show/NCT04694833; Unique identifier: NCT04694833, Date of registration: 11/24/2020.
A case report of drug interaction between co-packaged nirmatrelvir-ritonavir and tacrolimus causing hyponatremia in a lung transplant recipient
Authors: Lo Chien-Ming , Chen Wei-Hsun , Tsai Meng-Yun , Lu Hung-I , Hsiao Yu-Hsin , Chuang Kai-Hao , Chen Yu , Wu Hsuan-Feng , Huang Kuo-Tung , Wang Yi-Hsi
Published: March 2024

Background

Coronavirus disease 2019 (COVID-19) infection in lung transplant recipients can be lethal owing to the use of immunosuppressants. Antiviral agents may be administered to these patients. Co-packaged nirmatrelvir-ritonavir is a new agent currently being used in combination.

Case presentation

In this report, we present a case of a 64-year-old woman, a lung transplant recipient, who experienced hyponatremia and showed a high serum tacrolimus concentration following the administration of the co-packaged nirmatrelvir-ritonavir combination.

Conclusion

Although the nirmatrelvir-ritonavir and tacrolimus combination is not contraindicated, other treatment strategies should be considered first, if available, and the dose of tacrolimus should be reduced when using the nirmatrelvir-ritonavir combination. In cases where combination therapy is necessary, serum tacrolimus levels should be closely monitored in lung transplant recipients. Documentation of more such reports is important to identify drug interactions between nirmatrelvir-ritonavir and other agents, with the aim of preventing severe adverse effects.
Fixation devices made of poly-L-lactide composite for rib reconstruction after thoracotomy
Authors: Fukunaga Naoto , Sato Hideki , Wakami Tatsuto , Shimoji Akio , Mori Otohime , Yoshizawa Kosuke , Tamura Nobushige
Published: March 2024

GRAND FIX mesh-type plates and pins (Gunze, Kyoto, Japan) are thin, bioabsorbable fixation devices made of poly-L-lactide (PLLA) composite. These devices are new, and how best to use them in clinical practice remains to be determined. Thus, we describe our approach to rib fixation after thoracotomy in an aortic surgery using GRAND FIX mesh-type plates and pins. The advantage of our approach is that it is easy to perform, but careful attention should be paid to fix the ribs appropriately.
Dystocia in cattle and horses: a compilation of historical artworks dedicated to Professor Gerhard Sand (1861–1921)
Authors: Agerholm Jørgen Steen , Christoffersen Mette , Secher Jan Boysen-Møller , Normann Annika , Pedersen Hanne Gervi
Published: March 2024

Professor Gerhard Sand (1861–1921) was the first professor of veterinary obstetrics at the Royal Veterinary and Agricultural University, Copenhagen, Denmark. He began teaching the theory and practice of obstetrics to veterinary students in 1887 and spent the following years until his death in 1921 developing the veterinary obstetrics teaching program. During this period, veterinary obstetrics was established as an independent discipline at the Royal Veterinary and Agricultural University. Professor Sand’s teaching had a major impact on the field of veterinary obstetrics in Scandinavia. He was devoted to teaching veterinary obstetrics and produced a number of obstetrical illustrations, some of which showed different causes of dystocia, mainly fetal malpresentation in cattle and horses. Professor Sand created the illustrations with the intention of publishing a handbook of obstetrics, but due to illness and an early death, this work was never completed. This compilation of historical artworks of dystocia in cattle and horses includes some of these illustrations and is published to honour Professor Sand, with the intention of making his illustrations widely available for the teaching of veterinary obstetrics.
Scrutinizing mechanical circulatory support in cardiogenic shock: Have we jumped the gun?
Authors: Lüsebrink Enzo , Lanz Hugo , Thiele Holger
Published: March 2024

Despite increasing therapeutic options and disposable resources, cardiogenic shock (CS) remains a formidable condition with high mortality. Today, veno-arterial extracorporeal membrane oxygenation and microaxial flow devices (Impella, Abiomed, Danvers, USA) are established forms of mechanical circulatory support (MCS) in CS, with increasing application over the years. Despite this trend, incorporation into current ESC (Class IIa, evidence C) and AHA/ACC (Class IIa, evidence B-NR) guidelines is based nearly exclusively on observational results. Despite these recommendations and increasing application, current evidence from randomized controlled trials has not provided clear mortality benefit. Thus, reflection on current evidence is hereby justified.
Carbon and energy balance of biotechnological glycolate production from microalgae in a pre-industrial scale flat panel photobioreactor
Authors: Wagner Heiko , Schad Antonia , Höhmann Sonja , Briol Tim Arik , Wilhelm Christian
Published: March 2024

Glycolate is produced by microalgae under photorespiratory conditions and has the potential for sustainable organic carbon production in biotechnology. This study explores the glycolate production balance in Chlamydomonas reinhardtii, using a custom-built 10-L flat panel bioreactor with sophisticated measurements of process factors such as nutrient supply, gassing, light absorption and mass balances. As a result, detailed information regarding carbon and energy balance is obtained to support techno-economic analyses. It is shown how nitrogen is a crucial element in the biotechnological process and monitoring nitrogen content is vital for optimum performance. Moreover, the suitable reactor design is advantageous to efficiently adjust the gas composition. The oxygen content has to be slightly above 30% to induce photorespiration while maintaining photosynthetic efficiency. The final volume productivity reached 27.7 mg of glycolate per litre per hour, thus, the total process capacity can be calculated to 13 tonnes of glycolate per hectare per annum. The exceptional volume productivity of both biomass and glycolate production is demonstrated, and consequently can achieve a yearly CO2 sequestration rate of 35 tonnes per hectare. Although the system shows such high productivity, there are still opportunities to enhance the achieved volume productivity and thus exploit the biotechnological potential of glycolate production from microalgae.
Onchocerca volvulus microfilariae in the anterior chambers of the eye and ocular adverse events after a single dose of 8 mg moxidectin or 150 µg/kg ivermectin: results of a randomized double-blind Phase 3 trial in the Democratic Republic of the Congo, Ghana and Liberia
Authors: Kanza Eric M. , Nyathirombo Amos , Larbelee Jemmah P. , Opoku Nicholas O. , Bakajika Didier K. , Howard Hayford M. , Mambandu Germain L. , Nigo Maurice M. , Wonyarossi Deogratias Ucima , Ngave Françoise , Kennedy Kambale Kasonia , Kataliko Kambale , Bolay Kpehe M. , Attah Simon K. , Olipoh George , Asare Sampson , Mumbere Mupenzi , Vaillant Michel , Halleux Christine M. , Kuesel Annette C.
Published: March 2024

Background

After ivermectin became available, diethylcarbamazine (DEC) use was discontinued because of severe adverse reactions, including ocular reactions, in individuals with high Onchocerca volvulus microfilaridermia (microfilariae/mg skin, SmfD). Assuming long-term ivermectin use led to < 5 SmfD with little or no eye involvement, DEC + ivermectin + albendazole treatment a few months after ivermectin was proposed. In 2018, the US FDA approved moxidectin for treatment of O. volvulus infection. The Phase 3 study evaluated SmfD, microfilariae in the anterior chamber (mfAC) and adverse events (AEs) in ivermectin-naïve individuals with ≥ 10 SmfD after 8 mg moxidectin (n = 978) or 150 µg/kg ivermectin (n = 494) treatment.

Methods

We analyzed the data from 1463 participants with both eyes evaluated using six (0, 1–5, 6–10, 11–20, 21–40, > 40) mfAC and three pre-treatment (< 20, 20 to < 50, ≥ 50) and post-treatment (0, > 0–5, > 5) SmfD categories. A linear mixed model evaluated factors and covariates impacting mfAC levels. Ocular AEs were summarized by type and start post-treatment. Logistic models evaluated factors and covariates impacting the risk for ocular AEs.

Results

Moxidectin and ivermectin had the same effect on mfAC levels. These increased from pre-treatment to Day 4 and Month 1 in 20% and 16% of participants, respectively. Six and 12 months post-treatment, mfAC were detected in ≈5% and ≈3% of participants, respectively. Ocular Mazzotti reactions occurred in 12.4% of moxidectin- and 10.2% of ivermectin-treated participants without difference in type or severity. The risk for ≥ 1 ocular Mazzotti reaction increased for women (OR 1.537, 95% CI 1.096–2.157) and with mfAC levels pre- and 4 days post-treatment (OR 0: > 10 mfAC 2.704, 95% CI 1.27–5.749 and 1.619, 95% CI 0.80–3.280, respectively).

Conclusions

The impact of SmfD and mfAC levels before and early after treatment on ocular AEs needs to be better understood before making decisions on the risk-benefit of strategies including DEC. Such decisions should take into account interindividual variability in SmfD, mfAC levels and treatment response and risks to even a small percentage of individuals.

Graphical Abstract
The spleen is the graveyard of CD4+ cells in patients with immunological failure of visceral leishmaniasis and AIDS
Authors: Reinaldo Luis Gustavo Cavalcante , Araújo Júnior Raimundo José Cunha , Diniz Thiago Melo , Moura Rafael de Deus , Meneses Filho Antônio José , Furtado Caio Victor Verçosa de Macedo , dos Santos Washington Luis Conrado , Costa Dorcas Lamounier , Eulálio Kelsen Dantas , Ferreira Gabriel R. , Costa Carlos Henrique Nery
Published: March 2024

Background

Visceral leishmaniasis (VL), or kala-azar, is a common comorbidity in patients with AIDS in endemic areas. Many patients continue to experiences relapses of VL despite virological control, but with immunological failure. These patients remain chronically symptomatic with hypersplenism, for example with anemia, leukopenia, and thrombocytopenia, and are at risk of severe co-infection due to low CD4+ count. Therefore, in this study, splenectomized patients with VL and HIV infection were investigated to understand why the CD4+ count fails to recover in these patients, evaluating the importance of spleen mass for hypersplenism and immunological failure.

Methods

From a retrospective open cohort of 13 patients who had previously undergone splenectomy as salvage therapy for relapsing VL, 11 patients with HIV infection were investigated. This study compared the patients’ complete blood cell count (CBC) and CD4+ and CD8+ cell counts before and after splenectomy with respect to spleen weight.

Results

CBC was substantially improved after splenectomy, indicating hypersplenism. However, to the best of our knowledge, this is the first study to show that spleen mass is strongly and negatively correlated with CD4+ cell count (ρ = −0.71, P = 0.015).

Conclusions

This finding was unexpected, as the spleen is the most extensive lymphoid tissue and T-lymphocyte source. After reviewing the literature and reasoning, we hypothesized that the immunological failure was secondary to CD4+ loss initially by apoptosis in the spleen induced by productive HIV infection and, subsequently, by pyroptosis sustained by parasitic infection in spleen macrophages.

Graphical Abstract
Optimizing the resource allocation in cyber physical energy systems based on cloud storage and IoT infrastructure
Authors: Bai Zhiqing , Li Caizhong , Pourzamani Javad , Yang Xuan , Li Dejuan
Published: March 2024

Given the prohibited operating zones, losses, and valve point effects in power systems, energy optimization analysis in such systems includes numerous non-convex and non-smooth parameters, such as economic dispatch problems. In addition, in this paper, to include all possible scenarios in economic dispatch problems, multi-fuel generators, and transmission losses are considered. However, these features make economic dispatch problems more complex from a non-convexity standpoint. In order to solve economic dispatch problems as an important consideration in power systems, this paper presents a modified robust, and effective optimization algorithm. Here, some modifications are carried out to tackle such a sophisticated problem and find the best solution, considering multiple fuels, valve point effect, large-scale systems, prohibited operating zones, and transmission losses. Moreover, a few complicated power systems including 6, 13, and 40 generators which are fed by one type of fuel, 10 generators with multiple fuels, and two large-scale cases comprised of 80 and 120 generators are analyzed by the proposed optimization algorithm. The effectiveness of the proposed method, in terms of accuracy, robustness, and convergence speed is evaluated, as well. Furthermore, this paper explores the integration of cloud storage and internet of things (IoT) to augment the adaptability of monitoring capabilities of the proposed method in handling non-convex energy resource management and allocation problems across various generator quantities and constraints. The results show the capability of the proposed algorithm for solving non-convex energy resource management and allocation problems irrespective of the number of generators and constraints. Based on the obtained results, the proposed method provides good results for both small and large systems. The proposed method, for example, always yields the best results for the system of 6 power plants with and without losses, which are $15,276.894 and $15,443.7967. Moreover, the improvements made in the proposed method have allowed the economic dispatch problem regarding multi-fuel power plants to be solved not only with optimal results ($623.83) but also in less than 35 iterations. Lastly, the difference between the best-obtained results ($121,412) and the worst-obtained results ($121,316.1992) for the system of 40 power plants is only about $4 which is quite acceptable.
Psychometric properties of the Arabic version of the intolerance of uncertainty scale: a multinational study
Authors: Chaaya Roni , Hallit Rabih , Postigo Alvaro , Malaeb Diana , Sakr Fouad , Dabbous Mariam , Alhuwailah Amthal , Shuwiekh Hanaa Ahmed Mohamed , Obeid Sahar , Fekih-Romdhane Feten , Hallit Souheil
Published: March 2024

Introduction

It is common for people to experience anxiety when contemplating their unknown future. Studies have shown that those who tend to worry more about their future are more likely to be intolerant of uncertainty. In order to study the way people from the Middle East tackle uncertainty, a valid and reliable scale is needed. In this context, the present study aimed to examine the psychometric properties of the Arabic version of the 12-item Intolerance of Uncertainty Scale (IUS-12) in a community sample of native Arabic–speaking participants from Lebanon, Egypt, and Kuwait.

Methods

A sample of 2038 university students answered the survey, with a mean age of 22.30 ± 4.15 years and 77.5% females. A Google Form link was dissipated among participants that included some demographic questions, the IUS-12 and the Depression, Anxiety and Stress Scale (DASS-8).

Results

Following the confirmatory factor analysis (CFA), a bi-dimensional model of the Arabic version of the IUS-12 was found. The scale showed an excellent internal reliability for the prospective anxiety (ω = 0.85 / α = 0.85) and inhibitory anxiety (ω = 0.87 / α = 0.87). Additionally, the results illustrated configural, metric, and scalar invariance across genders and countries. Furthermore, Egypt and Lebanon were seen to have statistically significant higher levels of inhibitory anxiety compared to Kuwait, while only Egypt showed statistically significant higher prospective anxiety compared to Kuwait. Finally, higher psychological distress was significantly and positively associated with higher prospective and inhibitory anxiety.

Conclusion

The results of this study provide support for the psychometric reliability and validity of the Arabic version of the IUS-12, allowing for its generalizability and suitability for use among individuals from different Arabic-speaking nations.
Quality of life among residents of Gaza, Palestine: the predictive role of mental distress, fear of COVID-19, and social support
Authors: Jalala Suhayla Said , Veronese Guido , Diab Marwan , Abu Jamei Yasser , Hamam Rawya , Kagee Ashraf
Published: March 2024

Background

Living under siege and deteriorated health, social, educational, and economic conditions and isolation with scarce opportunities to fulfil basic needs and aspirations affect the civil population's mental health and perceived quality of life. In this cross-sectional investigation, we explored the consequences of mental distress, fear of COVID-19, and social support for QoL in the Gaza strip.

Methods

Nine hundred seventy nine (32.9% males; 67.1% females; mean age was 35.2 years; s.d. = 11.4) adults were recruited in the Gaza strip. We used the Fear for COVID-19 scale (FCS-19), The WHOQOL-BREF Scale, Berlin Social Support Scale (BSSS), Depression Anxiety and Stress Scale (DASS). Pearson correlation coefficient was computed to assess relationships between quality of life, fear of COVID19, mental distress, and social support; a hierarchical regression analysis was used to assess the association between QoL as the dependent variable and demographic variables and fear of COVID19, mental health, and social support as the independent variables.

Results

QoL was positively associated with perceived emotion, instrumental, and support seeking. Depression, anxiety, stress, and fear of COVID19 were negatively associated with quality of life. Gender was significantly associated with lower QoL. The study highlighted that the level of fear of COVID-19 was negatively influencing individuals' quality of life (QoL). This fear was negatively associated to psychological distress, gender, place of residence, and family type. Lower-educated and poorer participants had lower QoL scores. Conversely, female gender was notably linked to a lower QOL. The hierarchical regression confirmed that COVID-19 was an added burden for the Palestinian population. The fear of COVID-19 term added a 6.2% variance in QoL. In the final analysis, all predictors were statistically significant, with the fear of COVID-19 term recording a higher contribution of 22.5%, followed by depression term with 21.5%, perceived emotional 18.5%, income at 15.4%, and perceived instruments at 14.8% towards QoL.

Conclusions

Practitioners and policymakers must consider the severe violation of human rights when developing psychosocial programs to intervene in the COVID-19 crisis.
Gravimetric and morpho-structural analyses in the superhot geothermal system Los Humeros: an example from central Mexico
Authors: Cornejo-Triviño Natalia , Liotta Domenico , Piccardi Luigi , Brogi Andrea , Kruszewski Michal , Perez-Flores M.A , Carrillo Jonathan , Calcagno Philippe , Sass Ingo , Schill Eva
Published: March 2024

The influence of deep and regional geological structures is becoming increasingly important in superhot geothermal systems due to their proximity to the transition between brittleness and ductility. In the Los Humeros geothermal field in Mexico, where subsurface fluids reach temperatures of over 350 °C, the surface structures resulting from the collapse of calderas have so far only been interpreted at the local scale. The aim of this work is to place the recent tectonic and volcano-tectonic geomorphologic evolution and structures in the Los Humeros volcanic area in a regional context. NE- and NW-striking dominant structures resulting from a morpho-structural analysis on a regional scale are confirmed by negative and positive anomalies, respectively, after Butterworth filtering of gravity field data with different wavelengths over a local area of about 1000 km2. By analyzing the slip and dilation trends of the observed directions, we show the relevance of the regional context for reservoir exploration. The magnitudes of the principal stresses we estimate indicate a trans-tensional fault regime, a combination of strike-slip and normal faulting. The structures derived from the gravity and morpho-structural analyses, which are parallel to the maximum horizontal stress, have the highest potential for tensile and shear failure. Therefore, the corresponding negative gravity anomalies could be related to fracture porosity. Consequently, we hypothesize that these structures near the transition between brittleness and ductility control fluid flow in the Los Humeros geothermal field.
City-scale monitoring of antibiotic resistance genes by digital PCR and metagenomics
Authors: Maestre-Carballa Lucia , Navarro-López Vicente , Martinez-Garcia Manuel
Published: March 2024

Background

Anthropogenic activities significantly contribute to the dissemination of antibiotic resistance genes (ARGs), posing a substantial threat to humankind. The development of methods that allow robust ARG surveillance is a long-standing challenge. Here, we use city-scale monitoring of ARGs by using two of the most promising cutting-edge technologies, digital PCR (dPCR) and metagenomics.

Methods

ARG hot-spots were sampled from the urban water and wastewater distribution systems. Metagenomics was used to provide a broad view of ARG relative abundance and richness in the prokaryotic and viral fractions. From the city-core ARGs in all samples, the worldwide dispersed sul2 and tetW conferring resistance to sulfonamide and tetracycline, respectively, were monitored by dPCR and metagenomics.

Results

The largest relative overall ARG abundance and richness were detected in the hospital wastewater and the WWTP inlet (up to ≈6,000 ARGs/Gb metagenome) with a large fraction of unclassified resistant bacteria. The abundance of ARGs in DNA and RNA contigs classified as viruses was notably lower, demonstrating a reduction of up to three orders of magnitude compared to contigs associated to prokaryotes. By metagenomics and dPCR, a similar abundance tendency of sul2 and tetW was obtained, with higher abundances in hospital wastewater and WWTP input (≈125–225 ARGs/Gb metagenome). dPCR absolute abundances were between 6,000 and 18,600 copies per ng of sewage DNA (≈105–7 copies/mL) and 6.8 copies/mL in seawater near the WWTP discharging point.

Conclusions

dPCR was more sensitive and accurate, while metagenomics provided broader coverage of ARG detection. While desirable, a reliable correlation of dPCR absolute abundance units into metagenomic relative abundance units was not obtained here (r2 < 0.4) suggesting methodological factors that introduce variability. Evolutionary pressure does not significantly select the targeted ARGs in natural aquatic environments.
Knowledge, attitudes, and practices related to dengue among public school teachers in a Central Luzon Province in the Philippines: an analytic cross-sectional study
Authors: Gregorio Ernesto R. , Takeuchi Rie , Hernandez Paul Michael R. , Medina John Robert , Kawamura Shin-ya , Salanguit Mikaela B. , Santillan Marian Danille C. , Ramos Kimberly Mae S. , Tuliao Gideon John , Morales Lyndon , Palatino Maylin , Shibuya Fumiko , Kobayashi Jun
Published: March 2024

Background

Dengue has become a major health issue in tropical regions as the numbers of reported cases and estimated infections continuously increase. In the Philippines, many challenges remain in preventing and controlling the disease amidst all the mitigation efforts of the government. This study sought to measure the health literacy of Filipino teachers and determine the associations among teachers’ knowledge, attitudes, and selected practices (KAP) against dengue.

Methods

Elementary and secondary school teachers from the consistently declared dengue hotspots in the City of San Fernando, Pampanga, Philippines, from the years 2017 to 2019 were selected as target participants in this cross-sectional study. A self-administered online survey tool was used in this study for both screening of participants and the KAP survey proper. STATA, descriptive statistics, and multiple logistic regression were used for the data analysis. Odds Ratios (ORs) and 95% confidence intervals (CIs) were reported.

Results

The study comprised 604 participants whose mean age was 38.4 years. Television was determined as the top media source of information, and various health staff were the most trusted and common source of information. Good knowledge on dengue treatment (OR = 1.81; 95% CI 1.18–2.78) and dengue prevention (OR = 1.85; 95% CI 1.26–2.71) were positively associated with having good practices on protection against mosquito bites. Good knowledge on dengue signs and symptoms (OR = 1.56; 95% CI 1.02–2.37) and dengue prevention (OR = 2.38; 95% CI 1.59–3.58) were positively associated with having good practices on preventing breeding sites. Those with positive perceived susceptibility to dengue had lower odds of having good practices on protection against mosquito bites (OR = 0.64; 95% CI 0.41–0.99) and of having good practices on preventing breeding sites (OR = 0.46; 95% CI 0.26–0.81).

Conclusion

Even with the existing dengue policies, programs, and strategies, and the high disease literacy rate of Filipinos, dengue remains a struggle with an increasing case rate. Therefore, specific concepts should be emphasized, and interventions should be fine-tuned to better reach and influence the target population to attain a dengue-free Philippines.
Designer cell therapy for tissue regeneration
Authors: Zama Noyuri , Toda Satoshi
Published: March 2024

Cancer cell therapy, particularly chimeric antigen receptor (CAR) T-cell therapy for blood cancers, has emerged as a powerful new modality for cancer treatment. Therapeutic cells differ significantly from conventional drugs, such as small molecules and biologics, as they possess cellular information processing abilities to recognize and respond to abnormalities in the body. This capability enables the targeted delivery of therapeutic factors to specific locations and times. Various types of designer cells have been developed and tested to overcome the shortcomings of CAR T cells and expand their functions in the treatment of solid tumors. In particular, synthetic receptor technologies are a key to designing therapeutic cells that specifically improve tumor microenvironment. Such technologies demonstrate great potential for medical applications to regenerate damaged tissues as well that are difficult to cure with conventional drugs. In this review, we introduce recent developments in next-generation therapeutic cells for cancer treatment and discuss the application of designer therapeutic cells for tissue regeneration.
Government responses to the COVID-19 pandemic of the Gulf Cooperation Council countries: good practices and lessons for future preparedness
Authors: Chen Shu , Guo Lei , Xie Yewei , Dong Di , Saber Rana , Alluhidan Mohammed , Alamri Adwa , Alfaisal Abdulrahman , Alazemi Nahar , Al-Farsi Yahya M. , Al Ohaly Yazid A. , Zhang Yi , Rakic Severin , Hamza Mariam , Herbst Christopher H. , Tang Shenglan
Published: March 2024

The COVID-19 pandemic has dramatically threatened the Gulf Cooperation Council (GCC) countries which have a large proportion of foreign workers. The governments of GCC countries have proactively implemented a comprehensive set of policy measures, and up to our knowledge, a systematic analysis of qualitative and quantitative evidence on the government response is still lacking. We summarized the GCC countries’ government response and quantitatively measured that response using four indexes—the Government Response Index, the Stringency Index, the Vaccine Index, and the Initial Response Index, to analyse their response for future pandemic preparedness. Overall, the government response of all the GCC countries to the COVID-19 pandemic has been comprehensive, stringent, and timely. Notably, the GCC countries have implemented comprehensive vaccine policies. In addition, they have worked actively to protect foreign workers to improve their access to health services and secure their essential living conditions, regardless of their immigrant status. All the GCC countries dynamically adjusted their response to the evolving COVID-19 epidemiological burden and started to relax the stringency of the control policies after the Omicron wave, though the governments had different response magnitudes as measured by the four indexes. These findings have provided several important lessons for future pandemic response and preparedness for countries with similar economic, demographic, and health contexts in (1) prompt actions of containment and closure policies with dynamic adjusting, (2) strengthening health system policies, (3) comprehensive vaccination policies with universal access, (4) equitable and free access to testing, diagnosis, and treatment for all, and (5) strengthening the resilience of health systems.
A review on solar water heating technology: Impacts of parameters and techno-economic studies
Authors: Eze Fabian , Egbo Munonyedi , Anuta Udochukwu John , Ntiriwaa Ossei-Bremang Rejoice , Ogola Julius , Mwabora Julius
Published: March 2024

Background

Solar water heating is a highly sustainable method of extracting thermal energy from the sun for domestic and industrial use. In residential buildings, thermal energy from a Solar Water Heater (SWH) can be used to heat spaces, shower, clean, or cook, either alone or in combination with conventional heating systems such as electricity- and fossil-fuel-based heaters. In the industrial sector, SWHs can be used in various high-temperature fluid processes, including chemical processing, manufacturing, power generation, and construction. Despite the technological advancements in water heating systems, there are still some significant technical and economic challenges that limit their widespread adoption and commercialization. Despite their potential to revolutionize the industry, these systems remain in the shadows of unsustainable water heating solutions.

Main body of the abstract

This paper reviews recent selected publications on the technical and techno-economic aspects of solar water heating technology. The discussions include the effects of some parameters and components on the overall thermal efficiency of the SWHs as well as the techno-economic prospects of the technology. In addition, the paper provides the existing research gaps and recommendations for future research directions.

Short conclusion

The present review paper is unique because it condenses the recent studies carried out on both the technical and techno-economic aspects of the SWHs. It provides a comprehensive framework for interested readers and researchers to gain insights into the technical and economic status of SWHs. However, it is not an exhaustive study. The information presented can aid researchers in conducting further research on the subject, as well as understanding the future of SWHs.
Growth, leaf anatomy, and photosynthesis of cotton (Gossypium hirsutum L.) seedlings in response to four light-emitting diodes and high pressure sodium lamp
Authors: Zhang Yichi , Liao Baopeng , Li Fangjun , Eneji A. Egrinya , Du Mingwei , Tian Xiaoli
Published: March 2024

Background

Light is a critical factor in plant growth and development, particularly in controlled environments. Light-emitting diodes (LEDs) have become a reliable alternative to conventional high pressure sodium (HSP) lamps because they are more efficient and versatile in light sources. In contrast to well-known specialized LED light spectra for vegetables, the appropriate LED lights for crops such as cotton remain unknown.

Results

In this growth chamber study, we selected and compared four LED lights with varying percentages (26.44%–68.68%) of red light (R, 600–700 nm), combined with other lights, for their effects on growth, leaf anatomy, and photosynthesis of cotton seedlings, using HSP lamp as a control. The total photosynthetic photon flux density (PPFD) was (215 ± 2) μmol·m−2·s−1 for all LEDs and HSP lamp. The results showed significant differences in all tested parameters among lights, and the percentage of far red (FR, 701–780 nm) within the range of 3.03%–11.86% was positively correlated with plant growth (characterized by leaf number and area, plant height, stem diameter, and total biomass), palisade layer thickness, photosynthesis rate (Pn), and stomatal conductance (Gs). The ratio of R/FR (4.445–11.497) negatively influenced the growth of cotton seedlings, and blue light (B) suppressed stem elongation but increased palisade cell length, chlorophyll content, and Pn.

Conclusion

The LED 2 was superior to other LED lights and HSP lamp. It had the highest ratio of FR within the total PPFD (11.86%) and the lowest ratio of R/FR (4.445). LED 2 may therefore be used to replace HPS lamp under controlled environments for the study of cotton at the seedling stage.
Xylan derived carbon sphere/graphene composite film with low resistance for supercapacitor electrode
Authors: Cai Jihai , Li Yujin , Qin Rongji , Li Guangsheng , Wang Xiaoying
Published: March 2024

Reduced graphene oxide (rGO) films suffer from low capacitance for inner unreduced oxygen functional groups, restacking of sheets and high contact resistance. Herein, carbon spheres derived from renewable xylan were added to graphene oxide with large sheet area to fabricate film by gelation and filtration, followed by in situ reduction for high-performance flexible supercapacitor. rGO film with transverse size about 13 μm showed a good specific capacitance of 967 mF/cm2 at a scanning rate of 5 mV/s and increased to 1786 mF/cm2 by in situ reducing its inner part, which generally remained oxidized due to outer hindering from hydrophobic graphene. Then, by hydrothermal carbonization of xylan and activation with KOH, activated carbon sphere (aXCS) was prepared, which had a diameter of 150–200 nm and a specific capacitance of 270 F/g. The aXCS acted as spacer and connector to avoid restacking of graphene sheets and decrease interlayer contact resistance, resulting 94% increase in capacitance performance from rGO film to aXCS/rGO film. Therefore, combined in situ reduction and enhancement through compositing aXCS, the final film (aXCS/rGO-AA) showed a boosted specific capacitance of 755 mF/cm2 at 1 mA/cm2 in double electrode system, power density of 22.5–2250 mW/cm2, and energy density of 11.88–25.2 mWh/cm2. Meanwhile, aXCS/rGO-AA had outstanding cycling stability that its specific capacitance maintained 108.7% after 10,000 cycles of charge–discharge, showing promising potential in wearable and portable electronics.

Graphical abstract
Chemical characterization, safety profile and antileiomyoma effects of Tetrapleura tetraptera Taubert (Fabaceae) fruit ethanol extract in Sprague Dawley rats
Authors: Imade Rose Osarieme , Ayinde Buniyamin Adesina , Uchendu Adaeze Phina , Innih Silvanus , Umar Aadam Anoghena , Agoreyo Oghenemaro Victory , Adesina John Marvelous
Published: March 2024

Background

Tetrapleura tetraptera Taubert (Fabaceae) fruits are employed by herbal practitioners in the management of uterine leiomyoma, but its usage in this regard and level of safety in chronic administration has not been sufficiently established. This study evaluated the toxicity effects of T. tetraptera ethanol fruit extract and explored its antileiomyoma effect in female Sprague Dawley (SD) rats.

Methods

Sub-chronic toxicity test of the extract was done, with biochemical and hematological changes as well as histopathology of organs assessed. Leiomyoma formation was induced in SD rats with monosodium glutamate (MSG) and the extract given at 100, 200 and 400 mg/kg doses, following both the preventive and curative methods. Total serum cholesterol, protein and estradiol were determined, as well as histopathology assessment of the uterus. Phytochemical profiling of the extract was evaluated by analytical high-performance liquid chromatography (HPLC).

Results

No significant alterations were seen in the biochemical and hematological indices in the toxicity test. The vital organs showed no changes at 200 mg/kg, but at 800 mg/kg it appeared to induce multiplication of glandular epithelium and stromal fibrosis in the uterus, and induced perivascular inflammation around the vessels of the heart. Total serum cholesterol and estradiol were significantly elevated (P ≤ 0.05) on treating normal female rats with 800 mg/kg MSG. Preventive and curative treatment of MSG-treated animals with the extract significantly decreased the elevated serum cholesterol (P ≤ 0.01) and estradiol (P ≤ 0.05). Histological studies of the uterus showed an amelioration of the proliferating fibroid cells with administration of the extract, which was more evident in the curative treatment. Result of HPLC analysis of the extract revealed rich composition in bioactive compounds such as umbelliferone, ferulic acid, aridanin, echinocystic acid, naringenin and hentriacontane.

Conclusion

The ethanol fruit extract of T. tetraptera is relatively safe in Sprague Dawley rats in low doses and has antifibroid potential as seen in its significant reduction in the elevated total cholesterol and estradiol content as well as its ability to decrease uterine leiomyoma proliferation, which may be due to its array of phytochemical constituents.
The interplay of body composition, pain intensity, and psychological status in Egyptian patients with knee osteoarthritis
Authors: Khalil Naylan Fayez Wahba , Hassan Marwa Mohamed , Elshatby Nehad Mohamed
Published: March 2024

Background

There is a clear relationship between poor mental health, obesity, and osteoarthritis (OA). Individuals who experience symptoms of anxiety and depression are more likely to report higher levels of pain and disability in OA. In addition, higher body mass index (BMI) levels can contribute to additional pain and disability in individuals with OA. We aimed to explore the interplay of Body composition, pain intensity, and psychological status in Egyptian patients with knee OA.

Results

This cross-sectional study included 60 patients with Knee OA diagnosed clinically according to the American College of Rheumatology (ACR) criteria. Body composition measurement was performed with an InBody analyzer. Pain was assessed by the pain visual analog scale (VAS), disability was measured with Western Ontario and McMaster Universities Osteoarthritis (WOMAC) scores, and depressed mood and/or anxiety was measured by the Hospital Anxiety and Depression Scale (HADS). Body mass index (BMI), total body fat (TBF) %, fat mass (FM), and fat mass index (FMI) were positively correlated with pain and disability in patients with knee OA. TBF% was positively correlated with depression and anxiety.

Conclusions

This study has shed light on the association between mental disorders, body composition measurements, knee pain, and disability. Interventions to treat osteoarthritis in elderly patients should focus on treating mood changes such as anxiety and depression, psychological support, and controlling body mass with proper diet and exercise programs.
Impact of Insulin-Induced Relative Hypoglycemia on Vascular Insulin Sensitivity and Central Hemodynamics in Prediabetes
Authors: Battillo Daniel J , Remchak Mary-Margaret E , Shah Ankit M , Malin Steven K
Published: March 2024

Context

Relative hypoglycemia (RH) is linked to sympathetic responses that can alter vascular function in individuals with type 2 diabetes. However, less is known about the role of RH on hemodynamics or metabolic insulin sensitivity in prediabetes.

Objective

Determine if RH alters peripheral endothelial function or central hemodynamics to a greater extent in those with prediabetes vs normoglycemia.

Methods

Seventy adults with obesity were classified using ADA criteria as prediabetes (n = 34 (28 F); HbA1c = 6.02% ± 0.1%) or normoglycemia (n = 36 (30 F); HbA1c = 5.4% ± 0.0%). Brachial artery endothelial function, skeletal muscle capillary perfusion, and aortic waveforms were assessed at 0 and 120 minutes of a euglycemic clamp (40 mU/m2/min, 90 mg/dL). Plasma nitrate/nitrite and endothelin-1 were measured as surrogates of nitric oxide–mediated vasodilation and vasoconstriction, respectively. RH was defined as the drop in glucose (%) from fasting to clamp steady state.

Results

There were no differences in age, weight, or VO2max between groups. The prediabetes group had higher HbA1c (P < .01) and a greater drop in glucose in response to insulin (14% vs 8%; P = .03). Further, heart rate increased in normoglycemia compared to prediabetes (P < .01), while forward wave (Pf) decreased in prediabetes (P = .04). Insulin also tended to reduce arterial stiffness in normoglycemia vs prediabetes (P = .07), despite similar increases in preocclusion diameter (P = .02), blood flow (P = .02), and lower augmentation index (P ≤ .05).

Conclusion

Compared with normoglycemia, insulin-induced RH corresponded with a blunted rise in heart rate and drop in Pf during insulin infusion in adults with prediabetes, independent of changes in peripheral endothelial function.
Effect of Breastfeeding Duration on Coagulation in Women With and Without History of Gestational Diabetes Mellitus
Authors: Fritsche Louise , Löffler Dorina , Kantartzis Konstantinos , Flehmig Gesine , Roden Michael , Fritsche Andreas , Birkenfeld Andreas L , Peter Andreas , Heni Martin , Hörber Sebastian
Published: March 2024

Context

Breastfeeding is associated with a reduced maternal risk for cardiovascular diseases (CVDs).

Objective

Since the underlying mechanisms are still poorly understood, we here examined the effect of breastfeeding on the plasmatic coagulation system in women with and without history of gestational diabetes mellitus (GDM).

Methods

A total of 76 participants of the German Gestational Diabetes Study (PREG; NCT04270578) were examined 14 months (interquartile range [IQR], 12-26 months) after delivery with a 5-point oral glucose tolerance test. Global coagulation tests, prothrombotic coagulation proteins (FII/FVII/FVIII/FIX), antithrombotic proteins (antithrombin, protein C/S), and endothelial markers (von Willebrand factor and plasminogen activator inhibitor 1) were determined. The Framingham risk score was used to estimate the 10-year CV risk. The effect of breastfeeding duration on coagulation was analyzed using multivariable linear models.

Results

The mean duration of breastfeeding was 11 months (IQR, 7-14 months). Overall, longer duration of breastfeeding was associated with lower CV risk (Framingham risk score; P = .05) and was negatively associated with FIX (P = .018). We detected an interaction between previous GDM and breastfeeding duration for FIX (PInteraction = .017): Only in women with GDM history was the duration of breastfeeding negatively associated with FIX activity (P = .016). This association persisted in statistical models adjusted for age, body mass index, insulin sensitivity, and C-reactive protein. The duration of breastfeeding was not associated with anticoagulant proteins and endothelial markers.

Conclusion

Longer duration of breastfeeding is associated with lower CV risk and an improved coagulation profile. Women with GDM history appear to benefit particularly from prolonged breastfeeding.
103 A Bifurcation Model Predicts Intravascular Catheter Herniation When Using Transradial Access in Neuroendovascular Procedures
Authors: Lee Jin Vivian , Hartquist Chase , Qiu Michael , Suskin Charles , Chandrasekaran Vinay , Lowe Halle , Zayed Mohamed , Osbun Joshua W. , Genin Guy
Published: March 2024

INTRODUCTION:

The speed and safety of acute ischemic stroke interventions can be improved with catheter-based revascularization performed via the transradial access versus the traditional transfemoral access. A critical source of delay and procedural failure is a phenomenon known as herniation where the catheter system suddenly buckles and deviates from the intended endovascular pathway as the surgeon attempts to track one device over or through another around a tight bend.

METHODS:

Recent modeling work suggests that herniation is associated with a bifurcation in strain energy. We hypothesized that herniation could be predicted by modeling the strain energy stored in a catheter based on its flexural rigidity and the vascular anatomy. To test our hypothesis, we developed a computational model using finite element analysis and an experimental benchtop model using 3D-printed patient-specific aortic arches. Our mathematical model was validated in vivo using observational data derived from patient and porcine endovascular surgeries.

RESULTS:

Vascular geometry and flexural rigidity were used to derive the bifurcation condition and predict catheter stability versus instability (herniation). Catheter instability criterion was predictive of herniation in our computational model (sensitivity 100.0%, PPV 93.5%, NPV 100.0%); experimental ex vivo model (sensitivity 92.3%, PPV 89.6%, NPV 90.0%); patient in vivo model (sensitivity 100.0%, PPV 80.0%, NPV 100.0%); and porcine in vivo model (sensitivity 100%, PPV 100%, NPV 100%).

CONCLUSIONS:

We validated a predictive model of catheter herniation based upon the hypothesis that bifurcation in strain energy drive the phenomenon. Key factors in the model are the curvature of the vascular pathway and the flexural rigidity of the coaxial devices. Results suggest that strategic selection of catheters and wires based on their known flexural rigidity can be used to prevent the bifurcation in strain energy that causes herniation.