bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the Role of Serambi Indonesia Media in Improving Political Education in the 2019 Legislative Elections in Bireuen District, Aceh
Authors: Ali Chaidir
Published: November 2023

The role of the Serambi Indonesia media is urgently needed to have a positive effect on increasing political education for the public as voters in general elections because the media has a strong influence in shaping one's cognition, where the media provides information and knowledge that ultimately shapes perceptions, and perceptions will influence attitudes and behavior. The Serambi Indonesia media was chosen because the media contains a lot of political news and can keep up with the times. Serambi Indonesia is one of the largest print media spread across Aceh Province. This study aims to find out the role of the Serambi Indonesia media in increasing political education among the public in the 2019 legislative elections in the Bireuen Regency. This study uses a qualitative method. Qualitative research focuses on collecting data that is descriptive and analytical on the Serambi Indonesia website, intending to uncover more specific phenomena that can provide a more in-depth picture of Indonesian Serambi media in improving political education in the 2019 legislative elections in the Biereuen Regency. With that, Serambi Indonesia provides information or political news published by Serambi Indonesia which is very important and very influential. the reader in receiving the message conveyed.
Oblong True Shape Tablets as an Industrial Scale Digital Twin
Authors: Radeke Charles , Wang Zihan , Rabold Frank
Published: November 2023

Tablets are the most used solid dosage form in medical treatments. The realistic modeling 1 of such specific object shapes in computer simulations has been demonstrated already by the author 2 for bi-convex round tablets but needs to be extended for a wider range of tablet shapes. Moreover, 3 the number of tablets must be large enough to simulate industrial drum coaters, which are typically 4 used for film coating processes. Whilst this long lasting process where tablets flow continuously, 5 tablets are loaded by frequent changes of individual contacts. Using a tailored simulation tool named 6 pharmAssist , written for GPUs (modern massively parallel processors in graphics cards and HPC 7 accelerators), we implemented the widely used oblong tablet shape. We are able to simulate flows 8 involving industrial scale number of such tablets. Data mining allows for statistical analyzis of 9 pair-wise contacts of different geometric features. Our simulation results serves as an observation 10 space, which cannot be addressed by experimental analyzis and will help to avoid degradation of 11 tablets like chipping or other defect phenomena. This paper reflects current development work in 12 order to extend the DEM with a new shape class, which comprises the modelling of compacted or 13 extruded objects, which have a smooth exterior, a flat band and sharp contour edges
Examining the Sustainability of Digital Innovation in Chinese Enterprises through Strategic Knowledge Disclosure: The Mediating Role of Market Trust
Authors: Zeng Jing , Wang Chaofa , Wang Linxue
Published: November 2023

Aiming to investigate the impact of strategic knowledge disclosure on the continuous realization of digital innovation in enterprises, this study examines data from 168 listed companies across three high-tech industries in China from 2012 to 2021. By examining investor trust, consumer trust, worker trust, and rival trust as mediating variables within the market trust dimension, this research explores the impact mechanism of strategic knowledge disclosure on the sustainability of input and output in digital innovation. The findings reveal that strategic knowledge disclosure significantly promotes both input and output sustainability in digital innovation. Specifically, investor trust positively mediates the relationship between strategic knowledge disclosure and the sustainability of digital innovation input. Similarly, consumer trust and worker trust positively mediate the association between strategic knowledge disclosure and both input and output sustainability in digital innovation. However, it is important to note that rival trust negatively mediates the link between strategic knowledge disclosure and both input and output sustainability in digital innovation. The research findings possess significant theoretical value and provide valuable guidance for promoting the sustainable development of digital innovation in enterprises.
18. Yüzyılda İstanbul’dan Edirne’ye Yolculuk: Kadı Mehmed Nebih Efendi Örneği
Authors: ÖZYALVAÇ Şükriye Pınar
Published: November 2023

Yönetim merkezinden yapılan atamalar, çoğunlukla Osmanlı memurlarının şehirler arasında uzun sürecek bir yolculuğa çıkmaları anlamına gelirdi. Mevsim, coğrafi şartlar, uzaklık, güvenlik ve statü yolculuğu etkileyen etmenlerden yalnız birkaçıydı. Bu çalışmada, 18.yüzyılda İstanbul-Edirne arasında yapılan yolculukların mahiyeti, Edirne’ye kadı olarak atanan Mehmed Nebih Efendi örneği üzerinden anlaşılmaya çalışılmıştır. Çalışmanın ortaya çıkmasında, Başbakanlık Osmanlı Arşivi, Topkapı Sarayı tasnifinde yer alan 2204 numaralı Hesap Defteri önemli rol oynamıştır. 1758 tarihli defter, hane halkı ile yola çıkan Kadı efendinin seyahat konforunu anlamamıza yardımcı olacak verileri (İstanbul-Edirne arasındaki rota, konak yerleri, nakliye araçları, tüketim maddeleri) içermesi bakımından dikkate değerdir. Yüzyılın yol imkânları sebebiyle yolculukların yapılması izinlere tabidir. Çalışmanın başında memurun kim olduğu tespit edilmiş, hayatı hakkında bilinenler kısaca açıklanmıştır. Ardından kadılık sistemi ve Mehmed Nebih Efendi’nin Edirne Kadılığı’na atanma süreci, yolculuk hazırlıkları, izlenecek güzergâh ve konaklar arasındaki mesafeye yer verilmiştir. Son olarak Nebih Efendi’nin takip ettiği yolda yer alan köprüler, coğrafi şartlar, kaldığı yedi konağın her biri belgeler elverdiğince analiz edilmiş, konaklamalarda yapılan masraflar da eklenerek, üst düzey bir Osmanlı memurunun İstanbul-Edirne arasındaki yolculuğu anlatılmıştır.
lncRNA LINC00652 is a significant prognostic and diagnostic biomarker in the Isfahan Breast cancer patients, correlated to ID1: integrated bioinformatics and experimental approach
Authors: Saeri Mahdieh , Ramezani Zahra , Abbasi Samaneh , Foroutan Shamim , Azadeh Mansoureh
Published: November 2023

Background
The primary goal of this study is to compare the levels of expression of ID1, LINC00101, and LINC00652 in Isfahan Breast cancer samples to control samples. Understanding the relationship between variations in RNA expression levels and the clinicopathological statuses of Isfahan patients is another important goal of this research.
Method
R Studio evaluated 104 breast cancer tissue and 17 control samples in the GSE42568 microarray datasets to identify a relevant dysregulated gene. The limma package was used to conduct differential expression analysis. The DEGs were used to test mRNA-lncRNA interactions using the co-lncRNA online database. The qRT-PCR experiment aimed to determine the degree of expression of ID1, LINC001013, and LINC00652.
Result
Based on bioinformatics and experimental analyses, ID1 has a significant low-expression in the BC samples. Furthermore, lncRNAs LINC00101 and LINC00652 have significant high expression in the BC samples. ID1 and LINC00652 might be the two potential diagnostic (ROC analysis) and prognostic (Clinicopathological analysis) biomarkers of BC.
Discussion
According to ROC and clinicopathological analyses, ID1 and LINC00652 could be the two significant prognosis and diagnosis biomarkers in Isfahan Breast cancer patients.
In Silico Analysis of SOS Family in Areca palm (Areca catechu. L)
Authors: Alam Osama
Published: November 2023

The salt-overly sensitive ( SOS) gene is a signaling gene that helps plants to respond to high salinity stress. It is activated when cells are exposed to high levels of sodium ions, and it leads to a number of changes in gene expression that help the plant cope with high salinity stress. However, The SOS gene in Arecha palm has not been studied, despite being present in various plant species. We have identified 10 members of the AcatSOS family of genes, which are dispersed randomly over 5 chromosomes in the genome of Areca catechu. Using the phylogenetic analysis of 10 AcatSOS genes and two additional species rice and Arabidopsis—the tree is divided into 5 subfamilies: Group 1, Group 2, Group 3, Group 4 and Group 5. Each gene in the AcatSOS family was identified on its physiochemical properties. The plastid and vacuole contain most of the localization signals. Furthermore, there were numerous cis-acting areas and light-responsive elements in the promoter sequences of the AcatSOS genes. After the Areca palm genome was sequenced, segmental and tendom duplications were discovered, providing evidence of a major driving force in the evolution of the AcatSOS gene family. Areca palms share numerous genes, in terms of orthologous relationships, with other monocotyledonous plants because of their evolutionary affinity and related heritage. The development of the leaf, endocarp, and epicarp is regulated by the AcatSOS genes, according to circular heat. AcatSOS-4, AcatSOS-6 and AcatSOS-8 are highly regulated in plants. Genome-wide characterization of the SOS gene expression patterns has revealed that the expression of these genes is regulated in a complex manner. It is influenced by several factors, including the level of salinity stress, the developmental stage of the plant, and the tissue type.
Educating the Educators: Preparing Faculty to Teach Career ReadinessA Review of the Literature
Authors: Barnes Bobbie , Ullman Joanne , Heath Jenna , Shenouda Melikabella
Published: November 2023

Higher education institutions have witnessed recent changes surrounding career readiness. Assumptions can be made as to why that is - perhaps due to residual effects from the COVID-19 pandemic or the 2008 financial crisis - and although the rationale could be varied, the next steps are quite clear: universities must pivot and identify innovative ways to engage students for their career readiness. As such, a team comprised of administrative and academic faculty at a large, public, urban, R1 university collaborated to produce a Faculty Development for Career Readiness course. The asynchronous, web-based career readiness course provides insight and practice materials for the campus regarding six major career competencies (i.e., as identified by the National Association of Colleges and Employers (2016)): leadership, communication, cultural intelligence, emotional intelligence, problem solving and critical thinking, as well as professionalism. This program’s aim is to not only assist higher education professionals on how to effectively develop a practical course for academic faculty, but also to help support career competency-learning, and therefore, potential scaffolded teaching of such integral topics in the classroom, to in turn highlight a “collective responsibility” for undergraduates’ career readiness (Schlesinger et al., 2021).
Accessing Eye-level Greenness Visibility from Open-Source Street View Images: A methodological development and implementation in multi-city and multi-country contexts
Authors: Sánchez Ilse Abril Vázquez , Labib SM
Published: November 2023

The urban natural environment provides numerous benefits, including augmenting the aesthetic appeal of urban landscapes and improving mental well-being. While diverse methods have been used to evaluate urban greenery, the assessment of eye-level greenness visibility using street-view level images is emerging due to its greater compatibility with human perception. Many existing studies predominantly rely on proprietary street view images provider such as Google Street View (GSV) data; the usage restrictions and lack of alignment with FAIR (Findability, Accessibility, Interoperability, and Reusability) principles present challenges in using proprietary images at scale. Therefore, incorporating Volunteered Street View Imagery (VSVI) platforms, such as Mapillary, is emerging as a promising alternative. In this study, we present a scalable and reproducible methodological framework for utilising Mapillary images for Green View Index (GVI) assessment using image segmentation approach and evaluate the completeness and usefulness of such data in diverse geographical contexts, including eleven cities (i.e., Amsterdam, Barcelona, Buenos Aires, City of Melbourne, Dhaka, Ho Chi Minh, Kampala, Kobe, Mexico City, Seattle, and Tel Aviv). We also evaluate the use of globally available satellite-based vegetation indices (e.g., Normalised Difference Vegetation Index-NDVI) to estimate GVI in locations where street-view images are unavailable. Our approach demonstrates the applicability of Mapillary data for GVI assessments, although revelling considerable disparities in image availability and usability between cities located in developed and developing countries. We also identified that the NDVI could be used effectively to estimate GVI values in locations where direct street-level imagery is limited. Additionally, the analysis reveals notable differences in greenness visibility across cities, particularly in high-density, lower-income cities in Africa and South Asia, compared to low-density, high-income cities in the USA and Europe.
Statistical mechanics: autonomous to autonomous via non autonomous
Authors: Saito Cyprien
Published: November 2023

We are to formulate the invariant measures to fix compact subsets on the fluctuated situations for two autonomous systems in transition. Such a kind of two autonomous systems is formulated and intermediated by a certain formalism of their relevant non autonomous system that cannot be revealed other than by etale cohomology, l-adic cohomology and L-functions as the functionality of transmutations amidst them, that is, certain elements fixed in their integrability and in recurrence for their definition.
Biophysics of human interaction with the environment.
Authors: Pisarevsky Alexandr
Published: November 2023

The article considers the energy interaction of a person with the environment. Scientific evidence is given that a significant part of the energy a person receives comes not from food but from the environment, and a method for calculating this energy is given. The author's hypothesis is given, suggesting that a part of the energy of the environment, called by the author - "the energy of life", is used by the body of a living being, exclusively to maintain his life and health.
An efficient medium-fidelity model of anguilliform locomotion: insights into collective swimming efficiency and deformation dynamics
Authors: Dumoulin Denis , Chatelain Philippe
Published: November 2023

We propose a reduced-order model for the inviscid flow past self-propelled flexi- ble bodies whose geometry features a wedged trailing-edge. The model leverages an unsteady panel method and its compact representation of vorticity in the free flow allows for computationally tractable simulations. It is strongly coupled to a multi-body system solver which computes the internal bending moments in a swimming system of deforming bodies. The model is assessed against commer- cial computational fluid dynamics and vortex-method predictions on the specific case of anguilliform locomotion. The verified tool is subsequently leveraged in a campaign of numerical experiments to shed light on the collective benefits drawn from swimming in formation. We find that fish initially at rest and engaged in collective swimming demonstrate superior cost efficiency during the initial phases of their motion. However, beyond a certain temporal threshold, these piscine cohorts begin to expend more energy per unit of distance traversed in comparison to their solitary counterparts.
Real-time Prediction of Construction Waste Hauling Trucks’ Transportation Activities: An Input‒Output Hidden Markov Modelling Approach
Authors: Yang Hongtai , Lei Boyi , Han Ke , Liu Luna
Published: November 2023

Construction waste hauling trucks (CWHTs), as one of the most commonly seen heavy-duty vehicles in major cities around the globe, are usually subject to a series of regulations and access restrictions because they not only produce significant NOx and PM emissions but also causes on-road fugitive dust. To limit their environmental impact, specific spatial-temporal access restrictions are implemented, and timely and accurate detection of possible infringements has become a key challenge facing many municipal managers. To address this challenge, we propose a prediction method based on an interpretable activity-based model, input-output hidden Markov model (IOHMM), and apply it to trajectories of 300 CWHTs in Chengdu, China for evaluation. Contextual factors including weather conditions, recent transportation activities, and historical work statistics are considered in the model to improve its prediction power. Results show that the IOHMM has an average percentage of 64% for correctly predicting the destination and an average \({R}^{2}\) value of 69% for predicting the duration of the transportation activity. These values are higher than the results of the baseline models, including Markov chains, linear regression, and long short-term memory. To investigate the factors that influence the predictability of CWHTs’ transportation activities, linear regression models are constructed using the percentage of correct destination predictions and \({R}^{2}\) of the duration prediction model as the dependent variables, respectively. Our findings indicate that the number of active days and the proportion of days with nighttime activities are positively correlated with the prediction accuracy of both models. The average number of daily transportation activities and the number of different staying activities have positive and negative effects on the prediction accuracy of the destination model, respectively. In conclusion, the proposed model holds promise in assisting government agencies by predicting the next transportation activities of CWHTs and detecting infringements in a timely and effective manner.
Roman–barbarian relations in the light of the collection Panegyrici Latini (289-389 AD)
Authors: Skibiński Tomasz
Published: November 2023

The article discusses the issue of Roman-barbarian relations in the light of the collection Panegyrici Latini (3rd-4th century). Through the analysis of these texts, the article shows various aspects of these relationships. The extreme attitude of the Romans is the pursuit of the destruction of barbarian peoples or at least their subordination to Rome. However, numerous texts show different forms of integration of the two peoples, resulting from the deportations of barbarians to Roman territories for the personnel needs of the Empire (coloni and recruits). The article also discusses the role of the limes, which gradually becomes a meeting place rather than a border and expands the area of contact and integration.
Dominicans and Franciscans in Warka. The religious and social context of monastic foundations
Authors: Marszalska Jolanta M.
Published: November 2023

The mendican Orders, Dominicans and Franciscans, played a significant religious, economic, and cultural role over the past centuries at Warka in Mazovia. The foundation of the Dominican monastery was historically linked to the person of Duke Siemowit I. The Warka Dominican monastery, founded in the middle of the 13th century, next to the monasteries of St Dominic in Płock and of St Nicholas at Sochaczew belonging to the Mazovian contrat, is considered one of the oldest foundations of this order in Poland. In the mid-17th century, the Franciscans were brought to Warka. The foundress of the monastery was Katarzyna of Boglewice Trzebińska. With their presence, the Franciscans contributed to the religious revival of the town.
Biochemical Markers of Early Renal Dysfunction in Patients with β-thalassemia Major: A Systematic Review and Meta-analysis
Authors: Arian Mahdieh , Oghazian Mohammad Bagher , Noureldine Mohammad Hassan A. , Valinejad Ali , Badiee Zahra , Soleimani Mohsen , Sahebkar Amirhossein
Published: November 2023

Background::

Early diagnosis of renal dysfunction in β-thalassemia major (β-
TM) may help take specific measures to delay irreversible damage and renal failure.
Therefore, the present meta-analysis aimed to compare biochemical markers of premature
renal dysfunction between β-TM and healthy subjects and identify renal issues' prevalence
in patients with β-TM.

Methods::

We searched PubMed, Cumulative Index of Nursing and Allied Health Literature
(CINAHL), Medline, Scopus, Web of Science, ScienceDirect, ProQuest, Google
Scholar, and State Inpatient Databases (SIDs) without any language constraints for all relevant
articles published up to April 2019.

Results::

Out of 1458 articles published up to April 2019, 24 case-control and 22 crosssectional
studies were investigated. The investigated levels of serum phosphorus, uric acid
(UA), cystatin C, and ferritin were significantly different between β-TM patients and controls.
The albumin/creatinine ratio (ACR), N-acetyl-β-D-glucosaminidase/creatinine
(NAG/Cr) ratio, urinary and serum β2 microglobulin (β2MG), and serum ferritin levels
were significantly higher in β-TM patients than in healthy individuals. However, glomerular
filtration rate, creatinine clearance, and pretransfusion hemoglobin indicated a significantly
lower rate. The general prevalence of renal glomerular and/or tubular defects in patients
with β-TM was 50.22%.

Conclusion::

Urinary NAG, β2MG, ACR, and Scys-C may be early markers of renal dysfunction
in patients with β-thalassemia major. An observation of elevated levels of these
markers despite normal levels of other markers of renal dysfunction may indicate primary,
subclinical injury to the renal tubules and glomeruli.
Palliative Care in Children with Inherited Metabolic Diseases: Why does it matter?
Authors: Pereira Mendes Joana , Nogueira Andreia , Grilo Ema , Ferreira Sara , Diogo Luísa , Cancelinha Cândida
Published: November 2023

Background::

Inherited metabolic diseases (IMD) bring considerable burden on the
child and family. Challenging areas for health care include the identification of distressing
symptoms, prognostic uncertainty, and bereavement. Literature regarding the impact of paediatric
palliative care (PPC) is scarce.

Objective::

This study aims to evaluate children with IMD referred to a PPC team (PPCT) and to
analyse its impact on home care, decision to limit treatment (DLT), use of hospital resources
(emergency department admissions - EDA, hospital admissions – HA, intensive care admissions
– ICA) and end of life support.

Methods::

Retrospective cohort study of children with IMD referred to a specialized PPCT
(2016-2022). We assessed clinical data: symptoms control, time of referral and length of the
follow-up period, DLT, device dependency, use of hospital resources prior to and after referral,
place of death and end-of-life support.

Results::

Fifteen children with IMD were referred to PPCT (8% of total referrals), with median
age of 7 years (4 months – 17 years); 53% female. All children were non or pre-verbal. Most
prevalent symptoms were neurologic and motor impairment (100%), respiratory and gastrointestinal
(75%). 80% had tube feeding, 90% had some respiratory device (non-invasive ventilation
in 23%). All children had multidrug use, with a mean of 6 drugs per child (2-9). 73% had
home PPC and 80% had DLT planned. Nine children died (78% in hospital), after a mean of 17
months of follow-up (2 months to 4 years), all with DLT planned. 67% had support from PPCT
at the end of life. All these families received emotional support. Decrease in EDA (10 vs 2) was
noticed before and after PPCT. No impact was seen in HA and ICA (6 vs 5 and 1 vs 1, respectively)
and there was a longer mean of hospitalisation stay (15 vs 32 days).

Conclusion::

Our cohort includes a group of children with severe, complex and neurodegenerative
IMD. They need multiple medications for symptoms control, are highly dependent on medical
devices and consume significant healthcare resources. Communication impairment adds
complexity being a major barrier to symptom assessment. PPCT referral allowed home support,
anticipated care plans development with end of life and bereavement support, as well as a tendency
towards a reduction in EDA. These findings reinforce the need for holistic approach to
identify and address the PPC needs of children with IMD.
From Traditional Medicine to Advanced Therapeutics: The Renaissance of
Phyto-nano Interventions in Psoriasis
Authors: Semele Rajneesh , Grewal Sonam , Jeengar Manish Kumar , Singh Thakur Gurjeet , Swami Rajan
Published: November 2023

Psoriasis is an autoimmune systemic chronic inflammatory disease that exhibits characteristic
detrimental effects on the skin, often leading to infections or comorbid conditions. The
multifaceted nature of psoriasis has made it very challenging to treat, especially with current
chemotherapy options. Therefore, it is essential to consider phytoconstituents as novel alternatives.
However, despite demonstrating higher anti-inflammatory, anti-psoriasis, and immunomodulatory
potential, their clinical usage is hindered due to their poor physicochemical properties.
To address these drawbacks, nanoparticulate drug delivery systems have been developed,
helping to achieve better permeation of phytoconstituents through topical administration. This
has breathed new life into traditional systems of medicine, particularly in the context of treating
psoriasis. In this current review, we present a detailed, comprehensive, and up-to-date analysis
of the literature, which will contribute to affirming the clinical role of phyto-nano interventions
against psoriasis.
Optimal Look-Back Period to Identify True Incident Cases of Diabetes in Medical Insurance Data in the Chinese Population: Retrospective Analysis Study
Authors: Yang Wenyi , Wang Baohua , Ma Shaobo , Wang Jingxin , Ai Limei , Li Zhengyu , Wan Xia
Published: November 2023

Background

Accurate estimation of incidence and prevalence is vital for preventing and controlling diabetes. Administrative data (including insurance data) could be a good source to estimate the incidence of diabetes. However, how to determine the look-back period (LP) to remove cases with preceding records remains a problem for administrative data. A short LP will cause overestimation of incidence, whereas a long LP will limit the usefulness of a database. Therefore, it is necessary to determine the optimal LP length for identifying incident cases in administrative data.

Objective

This study aims to offer different methods to identify the optimal LP for diabetes by using medical insurance data from the Chinese population with reference to other diseases in the administrative data.

Methods

Data from the insurance database of the city of Weifang, China from between January 2016 and December 2020 were used. To identify the incident cases in 2020, we removed prevalent patients with preceding records of diabetes between 2016 and 2019 (ie, a 4-year LP). Using this 4-year LP as a reference, consistency examination indexes (CEIs), including positive predictive values, the κ coefficient, and overestimation rate, were calculated to determine the level of agreement between different LPs and an LP of 4 years (the longest LP). Moreover, we constructed a retrograde survival function, in which survival (ie, incident cases) means not having a preceding record at the given time and the survival time is the difference between the date of the last record in 2020 and the most recent previous record in the LP. Based on the survival outcome and survival time, we established the survival function and survival hazard function. When the survival probability, S(t), remains stable, and survival hazard converges to zero, we obtain the optimal LP. Combined with the results of these two methods, we determined the optimal LP for Chinese diabetes patients.

Results

The κ agreement was excellent (0.950), with a high positive predictive value (92.2%) and a low overestimation rate (8.4%) after a 2-year LP. As for the retrograde survival function, S(t) dropped rapidly during the first 1-year LP (from 1.00 to 0.11). At a 417-day LP, the hazard function reached approximately zero (ht=0.000459), S(t) remained at 0.10, and at 480 days, the frequency of S(t) did not increase. Combining the two methods, we found that the optimal LP is 2 years for Chinese diabetes patients.

Conclusions

The retrograde survival method and CEIs both showed effectiveness. A 2-year LP should be considered when identifying incident cases of diabetes using insurance data in the Chinese population.
A Web-Based Mindfulness-Based Cognitive Therapy for Couples Dealing With Chronic Cancer-Related Fatigue: Protocol for a Single-Arm Pilot Trial
Authors: Müller Fabiola , van Dongen Sophie , van Woezik Rosalie , Tibosch Marijke , Tuinman Marrit A , Schellekens Melanie P J , Laurenceau Jean-Philippe , van der Lee Marije , Hagedoorn Mariët
Published: November 2023

Background

Chronic fatigue is a common symptom among patients who have been treated for cancer. Current psychosocial interventions typically target the patient alone, despite growing evidence suggesting that a couples’ approach can increase and broaden the efficacy of an intervention. Therefore, based on an existing web-based mindfulness-based cognitive therapy for patients, the couple intervention COMPANION was developed.

Objective

The primary objectives of this study are to determine the acceptability of COMPANION and its potential efficacy in reducing fatigue in patients with cancer. Our secondary objectives are to examine the feasibility of the trial procedures and the potential working mechanisms of the couple intervention.

Methods

We will conduct a single-arm pilot trial for couples (ie, patients with cancer with chronic fatigue and their partners). All couples are allocated to the web-based couple intervention that consists of psychoeducation, mindfulness, and cognitive-behavioral exercises. The 9 sessions of the intervention are supervised remotely by a trained therapist. Patients and partners will complete questionnaires before starting the intervention (T0), 2 weeks after completing the intervention (T1), and 1 month after T1 (T2). They will also fill out weekly diaries during the intervention period. A subsample of patients (n≈5) and partners (n≈5) as well as all the therapists providing COMPANION will participate in the final focus groups. Benchmark values have been defined to determine the acceptability (ie, ≥60% of couples complete the intervention and/or ≥70% of the participants are satisfied with the intervention) and potential efficacy (ie, a significant improvement in fatigue and/or a clinically relevant improvement in fatigue in 45% of the patients between T0 and T1) of the intervention. The trial procedures are deemed feasible if an average of at least three couples are included per recruiting month and/or adherence to the assessments is at least 65% for T1 and the diaries and 60% for T2. To establish potential working mechanisms, changes in affect, sleep, catastrophizing, partner communication and interactions, self-efficacy, mindfulness, and closeness will be examined. Quantitative outcomes will be interpreted along with the results from the focus groups.

Results

Data collection is expected to be completed by March 2024.

Conclusions

This pilot trial will test the first web-based mindfulness-based cognitive therapy for couples targeting chronic cancer-related fatigue. Findings will indicate whether proceeding with a randomized controlled trial is warranted.

Trial Registration

ClinicalTrials.gov NCT05636696; https://clinicaltrials.gov/study/NCT05636696

International Registered Report Identifier (IRRID)

DERR1-10.2196/48329
Highly Facet-reflection Immune 53GBaud EML for 800G Artificial Intelligence Optical Transceivers
Authors: Huang Jack Jia-Sheng , Chang HsiangSzu , Hsu YiChing , Chiu Alex , Fang ZiHan , Hsiang Sam , Chen H.S.
Published: November 2023

We developed a facet-reflection immune 53GBaud electro-absorption modulated laser (EML) for 800G artificial intelligence (AI) optical network. An ultra-low anti-reflection (AR) coating reflectivity of 2x10-5 has been demonstrated for straight waveguide. Based on Hakki-Paoli method, we characterized the ultra-low AR using the ripple test technique. Such ultra-low AR is critical in achieving excellent eye pattern and optical transmission for 800G AI supercomputing.
A Study on the Protection of Traditional Villages in G City from the Perspective of Rural Revitalization Strategy: A Case Study of Moluo Village in Danba County
Authors: Li Guo
Published: November 2023

Based on the field investigation of traditional villages, cultural heritage and architectural features in G City, this paper analyzes the prominent problems and causes in the protection and development of traditional villages and cultural heritage in G City from the aspects of natural environment, economic development and villagers’ awareness. Further, it puts forward new paths for the protection and sustainable development of traditional villages and cultural heritage from the perspective of “rural revitalization” strategy, such as deepening the concept of co-construction and sharing, creating a new model of integrated development, and building a new method of digital resource sharing platform, so as to inherit and promote traditional Chinese culture.
Pacific Leadership and Impact on the Samoan Woman
Authors: Esera Epenesa , Pausisi Alo Silia
Published: November 2023

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The Literary Form and Revolution: The Politics of Melodrama in Late Chartist Literature
Authors: Hansan Thinkal
Published: November 2023

The period of late Chartism beginning in the late 1840s coincided with the transformation of the British press as a reaction to the advancement in industrial capitalism and the changing character of the public sphere to which it contributed directly. The resultant emergence of the British press in the mid nineteenth century from a political discourse to print journalism had direct political implication on the working class/Chartist press as well as their political agitation and plebeian public sphere. This paper will explore the effect of the ‘popular’ (both the press and culture) on the Chartist Press and literature and how the Chartist writers and editors including Ernest Jones and George W.M. Reynolds appropriated the emergent notion of the popular for radical political propaganda. I will argue that the staple rhetoric and dominant form of nineteenth century melodrama and sensationalism were used by these authors to create a distinctive class-conscious readership. Melodrama became, in the Chartist press, both an emotional reaction to the liberal capitalist economy’s classificatory politics as well as formed a resistance to the same creating a distinctive working class public sphere that publicized the private in political terms.
Deaf Helper Using Python
Authors: Patil Mr. Vrushab , Parit Mr. Pradeep , Yadav Miss. Ruchita , Yalgudre Mr. Aniruddha , Gurav Mr. Prathamesh , Desai Prof. P. R.
Published: November 2023

Abstract: The Deaf helper using machine learning project represents a pivotal endeavor aimed at bridging communication gaps and enhancing accessibility for the deaf and hard of hearing community. In a world where spoken language dominates, this project harnesses the power of machine learning to facilitate seamless communication for individuals who rely on sign language as their primary mode of expression. At its core, this project leverages state-of-the-art machine learning techniques, including computer vision and natural language processing, to recognize and translate sign language gestures into written or spoken language and vice versa. By fusing these technologies, the project endeavors to create an inclusive and accessible communication tool.
Malware Detection and Prevention Using ML
Authors: Jadhav Neha , Sanap Prof. Mrs. M. E. , Katore Samiksha , Mahadik Srushti , Shendage Akanksha
Published: November 2023

Abstract: The most prevalent issue on the internet today is malware. Due to its dynamic nature and ability to inherit characteristics from other types, polymorphic malware constantly modifies its properties to avoid being identified by traditional signature methodologies. The activity is carried out either at a certain moment or after a specific period of time. This study investigates machine learning model-based behavior-based detection techniques for detecting malware families and predict their presence through static or dynamic analysis.
The increase of bronchiolitis severity in the 2022-2023 season in an Italian tertiary children’s hospital: an isolated phenomenon or a warning sign?
Authors: Brisca Giacomo , Francesca Strati Marina , Buratti Silvia , Mariani Marcello , Ferretti Marta , Pirlo Daniela , Meleca Vincenzo , Piccotti Emanuela , Castagnola Elio , Moscatelli Andrea
Published: November 2023

Abstract:Aim: Recent literature has shown
epidemiological changes in bronchiolitis with an increased incidence in
the post-SARS-CoV-2 pandemic period but reports regarding disease
severity are conflicting. We aimed to describe the epidemiology, disease
severity, and microbiology of bronchiolitis during the 2022-2023 cold
season compared to the previous five years. Methods: This
single-center retrospective observational study at IRCCS Gaslini, Italy,
included all children aged 0-2 years hospitalized for bronchiolitis from
September 1st, 2017, to August 31, 2023. Findings from the 2022-2023
season were compared to the previous five years. Results: We
observed a statistically significant increase in the 2022-2023 season in
the absolute number of bronchiolitis admissions. Children who required
mechanical ventilation dramatically increased from a total of 7 patients
in the previous five seasons to 17 in the 2022-2023 season alone (
p=0.001). All other severity parameters significantly
increased: the need for respiratory support ( p=0.002)
, the median length of stay (5 vs. 4, p=0.001), and
the median duration of respiratory support (4 vs. 3, p=0.016).
Conclusions: We report a substantial increase in the severity
of bronchiolitis in the season 2022-2023 with a remarkable number of
previously healthy infants requiring mechanical ventilation. Our data
represents a call in our setting for urgent measures to plan
prophylactic and therapeutic strategies and prepare healthcare systems.
Further studies are needed to confirm whether our findings are an
isolated phenomenon or part of a true global trend. Health systems need
to be prepared and protective preventive measures should be implemented
for all newborns.
OsJAZ5 promotes salt tolerance in rice and physical interactions with OsMYL1 and OsMYL2 stimulate jasmonic acid signaling
Authors: Li Xiangyang , Ma Guangming , Zhang Yong , Liu Jing , Zhao Kunhong , Zhang Chun , Chen Mo-Xian , Kandegama Wishwajith , Sun Yao
Published: November 2023

Salt stress is one of the main abiotic stresses that affect plants. The
jasmonic acid ( JA) signaling pathway is an important pathway
that converts the normal growth state into the stress state when plant
cells encounter abiotic stress. OsJAZ5 is a JAZ protein
family gene, but how the JA signaling pathway promotes rice
responses to salt stress is unclear. In this study, after screening for
the OsJAZ5 gene, a yeast function analysis using the yeast mutant
Axt3k was performed to determine its salt resistance sensitivity.
The phenotype analysis showed that it was overexpressed in rice and
promoted growth under salt stress. An analysis of the superoxide
dismutase, peroxidase, phenylalanine ammonolyase, and catalase
activities showed that the OE-3 and OE-5 lines promoted OsJAZ5
activity to maintain the reactive oxygen species dynamic balance under
salt stress. In addition, the protein-protein interaction analysis and
protein-protein docking confirmed that OsJAZ5 interacts with
OsMYL1 and OsMYL2, demonstrated that OsJAZ5
promotes reactions by OsMYL1, OsMYL2, and OsMYC2
and that their expressions were further enhanced by OsJAZ5
through JA signaling of O sMYC2. Thus, expression of the
JA signaling response gene was activated by salt stress and its
effect on OsJAZ5 promoted salt tolerance in rice.
A New Shadow Frequency to Voltage Converter as a Read-out Circuit for Resistive Sensors
Authors: Al-Absi Muneer
Published: November 2023

This paper presents a shadow signal generator that produces
square and triangular waveforms. The oscillator frequency can be changed
using an external circuit (shadow oscillator). This method will make the
conversion speed better than the conventional oscillators. The technique
is based on utilizing an external circuit to modify the comparator’s
tripping point. The circuit is built using widely available commercial
integrated circuits, 1% accurate resistors, and DC supplies with a ±5V
voltage. The recommended setup is suitable for instrumentation where the
oscillation frequency is directly proportional to the variation in the
resistance of the sensor. The functionality of the proposed design was
confirmed by experimentation and simulation. The oscillation’s frequency
can be changed to be nearly 10 times greater than its starting value,
according to the results.
Rare eggshell structure in Odonata: Lindenia tetraphylla (Van der Linden) (Anisoptera: Gomphidae)
Authors: Salur Ali , Suludere Zekiye
Published: November 2023

Lindenia tetraphylla (Van der Linden, 1825) eggs exhibit an egg
structure that is very rare in other Gomphidae species. They have a
well-developed surface reticulation structure. The anterior pole of the
egg has a small, rounded micropylar area consisting of 7 orifices
arranged radially around a central area. The posterior pole has a
sessile, truncated cone that carries 55-65 coiled filaments. This study
provides a detailed analysis of the ultrastructure of L.
tetraphylla eggs using scanning electron microscopy, and the functional
and taxonomic significance of the eggshell are discussed.
POJĘCIE MIARY ODEJŚCIA OD RÓWNOMIERNOŚCI . ORAZ JEJ WPŁYW NA TESTOWANIE NIEZALEŻNOŚCI . W TABLICACH DWUDZIELCZYCH ŚREDNICH . ROZMIARÓW
Authors: Sulewski Piotr
Published: November 2023

Gdy hipoteza H0 o niezależności cech jest słuszna, bardzo często wówczas — za sprawą małych próbek — rozkład statystyki testowej odbiega od rozkładu chi-kwadrat. Kwantyl rozkładu chi-kwadrat nie jest zatem właściwą wartością krytyczną. Obecnie nie jest problemem wyznaczanie wartości krytycznej, lecz modelowanie H0. Modelowanie H0 to wypełnianie tablic, w których wartości cechy przypisane wierszom są niezależne od wartości cechy przypisanej kolumnom. W pracy zdefiniowano miarę odejścia od równomierności (mn). Gdy H0 jest słuszna, rozkład statystyki testowej zależy od mn. Wartość krytyczną należy ustalać z uwzględnieniem mn.
Causes and Risk Factors for Early Neonatal Mortality in the Western Region of Mongolia
Authors: Tsedev Solongo , Dashnyam Ulzii , Zagd Gerelmaa , Badrakh Burmaajav
Published: November 2023

Objectives: The incidence of perinatal, especially early neonatal mortality, has not been reducing in the western region of Mongolia, therefore, the purpose of this study was to identify causes and risk factors for early neonatal mortality in the western region of Mongolia. Methods: A case-control study for neonatal mortality was conducted in 5 hospitals in western Mongolia in 2014. Cases and controls were chosen from the hospitals. Associated causes and risk factors for early neonatal mortality were identified with subgroup binary logistic regression analyses. Results: A total of 7749 live births occurred during the study period. The early neonatal mortality rate was 11.3 per 1000 births. Obstetric complications, obstetric chronic history, abruption of placenta, preeclampsia and maternal diseases influenced early neonatal mortality. Respiratory distress syndrome (OR=29.4; 95% CI, 12.78-67.65, p<0.05), perinatal asphyxia (OR=5.2; 95% CI, 2.81-9.63, p≤0.001), congenital malformation (OR=39.2; 95% CI, 5.11-302.1) and perinatal infections (OR =11.1; 95% CI, 3.64-34.28, p≤0.001) were the leading causes of newborn death in the first week. Conclusion: Overall, high rates of neonatal death demonstrate the need to improve the quality of health care and the control of delivery and factors influencing early neonatal mortality should be studied further at the national level.>
Advanced Treatment of Intractable Childhood Epilepsy
Authors: Kwon Hye Eun , Kim Heung  Dong
Published: November 2023

Objectives: Up to one third of epilepsy patients have an unsatisfactory treatment with antiepileptic drugs (AEDs), but advance in neuroimaging, neurophysiologic investigation and treatment modalities have substantially improved the approaches and understanding of intractable childhood epilepsy. Methods: Journal papers, reports, books and government publications on epilepsy treatment were collected and reviewed in chronological order. Results: There are approximately more than 15 newer AEDs developed since 1990, highlighted by the novel mechanism of action with minimal adverse effect, thus they have been frequently used for those who are unresponsive to conventional AEDs. Non-pharmacologic therapies including diet therapy, epilepsy surgery, and neuromodulatory treatment are also effective and should be considered early in the disease course. Diet therapy began to reemerge in mid 1990s, and studies with large data collection allowed to overcome major concerns; its side effects, difficult compliance and doubts on efficacy. And more liberal forms of the diet therapy were introduced to benefit adults and patients in developing counties, where strict supervision is unavailable. The surgical treatment has become increasingly more valuable and it is now accepted for the management of drug resistant focal epilepsy due to major advances in presurgical investigation methods, and surgical techniques. Conclusions: The timely assessment of children with drug-resistant epilepsy and active application of advanced treatment modalities were necessary to prevent the effect of uncontrolled seizures on cognitive and behavioral development.
Dialysis Outcomes Among Elderly Populations in Asian Countries
Authors: Evsanaa Baigalmaa , Damdinsuren Khurtsbayar , Dagvasumberel Munkhbaatar , Togtokh Ariunaa
Published: November 2023

The inevitable reality of today is that the world population is aging, and the elderly (above 65 years) are more prevalent among the dialysis population worldwide. Objectives: The purpose of this review is to do a literature search on issues related to dialysis in the elderly Asian population, such as vascular access outcomes, complication rates, and survival data by modality on hemodialysis (HD) and peritoneal dialysis (PD). Methods: A literature search on key topic areas was done on articles published in English between January 1, 2005 and December 31, 2015. Results: Although incidences of elderly dialysis patients are increasing in Asia, we found that large-scale data is lacking. Further research is needed to assess dialysis outcomes among the elderly. Available studies suggest acceptable outcomes in vascular access, primary and secondary patency rates, and similar intervention rates compared to non-elderly. Survival data suggests superior outcomes in HD in elderly. Due to significant differences in dialysis practices in Asia, a proper comparison is difficult. Conclusion: Age alone is not a contraindication for dialysis.