bluuebunny/crossref_metadata_2025 huggingface dataset:
Nucleot(s)ide Analogs for Chronic Hepatitis Virus Therapy: A Global Bibliometric Analysis (1986-2022)
Authors: Putri Wahyu Aristyaning , Setiawan Jajar , Sofyantoro Fajar , Priyono Dwi Sendi , Septriani Nur Indah , Mafiroh Wulan Usfi , Siregar Abdul Rahman , Yano Yoshihiko , Wasityastuti Widya
Published: July 2024

Objectives: This  study  aimed  to  analyze  the  global  profile  of  the nucleotide/nucleoside  analogs  (NAs)  for  chronic  hepatitis virus therapy-related research.
Background: NAs, which closely resemble the structure of naturally occurring  nucleotides/nucleosides,  function  by  disrupting the elongation of the nascent DNA strand. These compounds are  considered  safe  and  well-tolerated,  as  they  specifically target  viral,  but  not  human,  polymerases  involved  in  DNA replication.  NAs  are  crucial  in  treating  viral  infections, including hepatitis, and are widely used due to their efficacy and safety. However, a study about trends in NAs for chronic hepatitis therapy-related research was never reported before.
Methods: The  NAs  for  chronic  hepatitis  therapy-related  research bibliometric  analysis  was  performed  on  articles  indexed  in the Scopus database from 1986 to 2022.
Results: The  total  number  of  articles  published  worldwide  is  2,341 documents,  with  an  annual  average  of  65  documents.  The United States generated the most articles (n = 486), followed by China (n = 454), France (n = 191), and Italy (n = 179). Since 1992, the number of publications has increased dramatically worldwide. Globally, liver cell carcinoma, antiviral therapy, hepatitis  B  (e)  antigen,  and  alanine  aminotransferase  are becoming hot research topics in the field.
Conclusions: This  study  provides  a  unique  composite  picture  of  NAs for  chronic  hepatitis  therapy-related  research  worldwide and  evaluates  research  productivity  from  1986  to  2022. This finding suggests that the prospects for interventions in chronic hepatitis remain promising.
Bangladesh Journal of Medical Science Vol. 23 No. 03 July’24 Page : 747-756
Assessment Of Trend And Instability Of Area And Production Of Mung Bean In Bangladesh
Authors: Prioty JK , Rahman KS , Miah MAM
Published: July 2024

Instability is an inherent aspect of agriculture due to its reliance on weather conditions, resulting in substantial fluctuations in crop area, production and yield. Mung bean (Vigna radiata) is one of Bangladesh’s most important pulses. It is highly valued for its nutritional composition and also helps improve soil health. This study focused on analyzing the changes in the cultivation area, production and yield of mung bean in Bangladesh through growth rate and instability analysis based on secondary data over a 40-year period (1981-2020). The entire timeframe was divided into four sub-periods:1981-1990,1991-2000,2001-2010 and 2011-2020 allowing for analysis using various statistical tools. Growth rates were calculated by fitting an exponential growth function, while instability was assessed using the Cuddy-Della Valle index. The analysis revealed that the area and production of mung beans had increased. The change in area and yield contributed respectively 51.3% and 46.8% to changes in the mean production of mung bean at the national level. Though the mung bean yields increased significantly, the rate of growth is slow, and it is insufficient to meet our country's demand. The analysis also revealed that the area, production, and yield of mung bean were not stable during the study period.
SAARC J. Agric., 22(1): 181-189 (2024)
IMPLEMENTASI APLIKASI PEMESANAN TIKET BERBASIS ANDROID DI CV SINGAPORE LAND WATERPARK BATU BARA
Authors: Umairoh Siti , Nurwati Nurwati , Rohminatin Rohminatin
Published: July 2024

CV. Singapore Land Waterpark Batu Bara merupakan sebuah perusahaan yang bergerak di bidang rekreasi (Waterpark) yang di resmikan Bupati Batu Bara Bapak OK Arya Zulkarnaen, SH, MM Pada tanggal 21 Desember 2016. Beralamat di Jl. Lintas Sumatera No.KM 141, Perkebunan Sei Balai, Kec. Sei Balai, Kabupaten Batu Bara. Permasalahan yang dialami perusahaan Singapore Land Waterpark adalah penjualan tiket yang masih di pesan ketika pengunjung harus mengantri untuk melakukan pembelian tiket. Hal ini membuat pengunjung tidak nyaman dalam segi waktu juga masih menggunakan sistem manual dalam pengolahan penjualan tiket sehingga kurang akurat dalam proses pembuatan laporan. Tujuan penelitian ini adalah membantu mempermudah penjuaan tiket dan mengelola informasi apa saja yang ada di dalam Waterpark Singapore Land. Metode yang digunakan pada penelitian ini dengan cara mengumpulkan data melalui observasi langsung dan wawancara. Penelitian ini juga didukung dengan metode kualitatif untuk memahami fenomena secara mendalam. Oleh karena itu, dibutuhkan sebuah aplikasi android pemesanan tiket online dengan menggunakan bahasa pemrograman PHP, database MySQL dikombinasikan dengan aplikasi kodular. Dengan aplikasi ini, Singapore Land Waterpark dapat menjual tiket kepada pengunjung dengan cepat tanpa harus mengantri, membantu pengunjung melakukan pemesanan tiket secara online melalui handphone serta mempermudah pegawai dalam pengelolaan data dan pembuatan laporan yang akurat.
PENERAPAN METODE MOORA DALAM MENGUKUR KINERJA KEPALA LINGKUNGAN PADA KELURAHAN BINJAI SERBANGAN
Authors: Ramadani Dilla , Syafwan Havid , Rahayu Elly
Published: July 2024

Kelurahan Binjai Serbangan yang berada di Jl. Protokol No.71, Binjai Serbangan, Kec. Air Joman, sebagai salah satu unit administratif di Asahan, menghadapi tantangan dalam pengukuran kinerja kepala lingkungan yang masih bersifat konvensional dan subjektif. Untuk mengatasi permasalahan ini, penelitian ini bertujuan untuk merancang dan membuat sistem komputerisasi pendukung keputusan yang menggunakan bahasa pemrograman PHP dan database MySQL serta memanfaatkan Metode Multi-Objective Optimization by Ratio Analysis (MOORA). Teknik pengumpulan data yang digunakan dalam data penelitian ini adalah dengan melakukan observasi langsung dan wawancara dengan lurah dan juga staff di Kelurahan Binjai Serbangan. Hasil penelitian menunjukkan bahwa penerapan Metode MOORA dalam pengukuran kinerja kepala lingkungan dapat meningkatkan objektivitas, efisiensi, dan transparansi dalam proses evaluasi. Ada 5 kriteria yang digunakan yaitu: Tingkat keluhan masyarakat, masa kerja, pelayanan publik, loyalitas dan kedisiplinan. Dengan aplikasi, dapat melakukan perhitungan secara otomatis sehingga mengurangi permasalahan pencarian keputusan, Hasil Perangkingan dalam pengukuran kinerja kepala lingkungan pada Kelurahan Binjai Serbangan maka didapatkan alternatif ke 12 atas nama Muslimsyah dengan nilai 0,311 dengan rangking teratas dan rangking terbawah adalah alternatif ke 10 atas nama M Arif Amsyar dengan nilai 0,099.
The efficacy of dalbavancin and impact on hospitalization and treatment costs in patients with ABSSSI
Authors: Carbonara Sergio
Published: July 2024

Acute bacterial skin and skin structure infections (ABSSSIs) represent a common and costly healthcare burden, accounting for millions of annual infections and billions of dollars in healthcare expenditures. Dalbavancin is a long-acting glycopeptide antibiotic that has demonstrated efficacy and safety in the treatment of ABSSSIs. This review article will examine the efficacy of dalbavancin and focus on its impact on the hospital length of stay and costs associated with management of these infections.
Uncovering the Motives and Essentials of Nascent Women Entrepreneurs
Authors: Cumberland Denise M. , Schreck Melissa , Kerrick Sharon A. , Flores Christopher
Published: July 2024

The aim of this article is to delve into women entrepreneurs’ motivations and perceptions of what is needed to achieve entrepreneurial success. Through semi-structured interviews, we found that most participants reported multiple reasons for wanting to be an entrepreneur; these motives were categorized as external and internal. Results also show what attributes and actions these women believe are critical to success. Our study contributes to the field by employing a qualitative design that uncovered the richness and diversity of women’s experiences in becoming business owners. The findings have implications for policymakers and organizations seeking to advance women entrepreneurship.
Percepções, conhecimentos e práticas em saúde bucal: Uma revisão integrativa
Authors: Sá Dayane Daniele Pereira de , Esmeraldo Anna Júlia Gonçalves , Silva João Marcos Ferreira de Lima , Damasceno Ulisses Solon Honorato , Noronha Andréa Honorato , Damasceno Neto Aldery de Paula
Published: July 2024

Ao longo da vida é necessário que hábitos de higiene e dieta sejam abordados como forma de prevenção a saúde bucal, de maneira que possa consolidar esses ensinamentos na vivência escolar e doméstica. Com isso definiu-se como objetivo verificar através de uma revisão de literatura a saúde bucal em escolares, voltada tanto aos seus conhecimentos quanto as percepções. Como metodologia trata-se de uma revisão integrativa de literatura, foram realizadas buscas na plataforma “Google escolar”, e elaborada a partir dos DECS, apresentados como: “Saúde bucal ou saúde oral”, “escolares ou crianças ou adolescentes”, “prevalência” e “cárie”. Diante dos achados observou-se que o conhecimento obtido pelos escolares é mediante encontros com profissionais da saúde bucal, familiares e com uma pequena parcela de participação das escolas. Além disso, foi possível identificar que estudantes com rendas mais baixas ou residentes de periferias apresentam reduções na qualidade da saúde bucal em comparação com escolares com maiores poderes aquisitivos e estudantes de escolas centrais. Ademais, os índices de CPO-D encontraram-se baixos, mas com tendencia a um aumento, sendo necessário medidas preventivas e assistenciais para manutenção da promoção de saúde.
Energia solar fotovoltaica autônoma na irrigação por pivô central
Authors: Berwanger Diego , Haupenthal Soni Willian , Siqueira Jair Antonio Cruz , Vilas Boas Marcio Antonio
Published: July 2024

O trabalho teve como objetivo avaliar o desempenho de um sistema de irrigação por pivô central utilizando energia de um sistema fotovoltaico isolado, através de um estudo quantitativo experimental em laboratório. O fornecimento de energia foi composto por oito módulos fotovoltaicos com potência de 665W e um inversor de frequência de 1,5kW, ligado por fim, diretamente ao sistema de bombeamento. Os parâmetros de potência do sistema fotovoltaico e do motor da bomba de água, foram medidos simultaneamente a coleta da vazão da água do pivô central. O experimento foi conduzido no Núcleo Experimental da Engenharia Agrícola (NEEA) da Universidade Estadual do Oeste do Paraná, UNIOESTE, realizando 5 dias de coleta com 30 ensaios por dia, totalizando 150 coleta. A geração de energia por parte do sistema fotovoltaico foi instável com coeficiente de variação de 9,82 a 56,74%, já os valores de pressão e vazão mantiveram-se dentro dos valores nominais de especificação de acordo com o índice de capacidade do processo. Os valores de uniformidade ficaram entre 54,78 e 61,38%, portanto classificados como ruins, entretanto destaca-se que a estabilidade da geração de energia melhorou a uniformidade. Os gráficos de controle de Shewhart, definiram que a presença de nuvens, bem como valores baixos de radiação afetam a geração de energia, pressão e vazão do sistema de irrigação, comprometendo a uniformidade. Sendo assim conclui-se que o layout do sistema em estudo não foi satisfatório para uma irrigação adequada por pivô central. Recomendado portanto a utilização de um banco de baterias para estabilizar a geração e consumo de energia.
Dynamic change of metabolic dysfunction-associated steatotic liver disease in chronic hepatitis C patients after viral eradication: A nationwide registry study in Taiwan
Authors: Huang Chung-Feng , Dai Chia-Yen , Lin Yi-Hung , Wang Chih-Wen , Jang Tyng-Yuan , Liang Po-Cheng , Lin Tzu-Chun , Tsai Pei-Chien , Wei Yu-Ju , Yeh Ming-Lun , Hsieh Ming-Yen , Huang Chao-Kuan , Huang Jee-Fu , Chuang Wan-Long , Yu Ming-Lung
Published: July 2024

Background/Aims: Steatotic liver disease (SLD) is a common manifestation in chronic hepatitis C (CHC). Metabolic alterations in CHC are associated with metabolic dysfunction-associated steatotic liver disease (MASLD). We aimed to elucidate whether hepatitis C virus (HCV) eradication mitigates MASLD occurrence or resolution.Methods: We enrolled 5,840 CHC patients whose HCV was eradicated by direct-acting antivirals in a nationwide HCV registry. MASLD and the associated cardiometabolic risk factors (CMRFs) were evaluated at baseline and 6 months after HCV cure.Results: There were 2,147 (36.8%) patients with SLD, and 1,986 (34.0%) of them met the MASLD criteria before treatment. After treatment, HbA1c (6.0% vs. 5.9%, P<0.001) and BMI (24.8 kg/m2 vs. 24.7 kg/m2, P<0.001) decreased, whereas HDL-C (49.1 mg/dL vs. 51.9 mg/dL, P<0.001) and triglycerides (102.8 mg/dL vs. 111.9 mg/dL, P<0.001) increased significantly. The proportion of patients with SLD was 37.5% after HCV eradication, which did not change significantly compared with the pretreatment status. The percentage of the patients who had post-treatment MASLD was 34.8%, which did not differ significantly from the pretreatment status (P=0.17). Body mass index (BMI) (odds ratio [OR] 0.89; 95% confidence intervals [CI] 0.85–0.92; P<0.001) was the only factor associated with MASLD resolution. In contrast, unfavorable CMRFs, including BMI (OR 1.10; 95% CI 1.06–1.14; P<0.001) and HbA1c (OR 1.19; 95% CI 1.04–1.35; P=0.01), were independently associated with MASLD development after HCV cure.Conclusions: HCV eradication mitigates MASLD in CHC patients. CMRF surveillance is mandatory for CHC patients with metabolic alterations, which are altered after HCV eradication and predict the evolution of MASLD.
Shore and mid-channel surveys reveal distinct phytoplankton-bacterial population associations along an urban estuary
Authors: Humphries GE , Ambrosone M , Roldan-Ayala Z , Brown M , Greenfield DI
Published: July 2024

A growing body of literature has highlighted the importance of phytoplankton-bacterial associations to marine and estuarine ecological and biogeochemical function, but their population linkages remain sparsely characterized within urban estuaries. Since many developed coastlines are heavily impacted by anthropogenic nutrient inputs, elucidating their phytoplankton-bacterial dynamics provides insight into nutrient cycling, productivity, and can help inform water quality management. This study compared surface (0.5 m depth) physical water quality, cell abundances of major phytoplankton taxa and bacteria, as well as concentrations of chlorophyll a (chl a) and dissolved organic matter (DOM) in the nitrogen (N)-enriched Western Long Island Sound (WLIS), USA, between mid-channel and shore sites (in 2020 and 2021). Shore bacterial and phytoplankton abundances as well as DOM concentrations (primarily dissolved organic N and carbon [DOC]), were significantly higher than mid-channel, especially during summer, indicative of terrestrial loading influencing microbial assemblages as well as N and C cycling. Abundances of key phytoplankton taxa were better indicators of bacterial abundances than chl a, as bacterial abundances positively and significantly correlated with those of dinoflagellates, especially the most common genera Prorocentrum (mid-channel, shore) and Heterocapsa (shore only), but not with diatoms. However, pennate diatom abundances negatively and significantly correlated with DOC concentrations in the mid-channel. Results highlight the impact of terrestrial inputs on WLIS microbial assemblage dynamics, presumably by favoring bacteria and dinoflagellate population coupling, as well as shed new ecological insight into how phytoplankton and bacterial communities respond to nutrient loadings in urban estuaries.
SPAIN’S EUROPEAN POLICY DURING ITS PRESIDENCY OF THE COUNCIL OF THE EU
Authors: SHAHBAZOV A.S. ,   Financial University under the Government of the Russian Federation, Moscow, Russian Federation
Published: July 2024

The article examines the main aspects of the Spain’s European policy as the President of the EU Council. The further course of the Kingdom’s European policy depends on the effectiveness of the Spanish government’s work in the Council in the second half of 2023. In addition to the main topic of the European agenda - geopolitical challenges - such important issues as energy independence and reduction of carbon dioxide emissions, migration, as well as taxation rules were touched upon. In addition, the integration process is discussed in the context of the new expansion policy. The Spanish government will have to balance a neutral position in the Council and the national interests of the country.
SOCIAL SERVICES FOR ORPHANS AND CHILDREN WITHOUT PARENTAL CARE IN ORGANIZATIONS FOR ORPHANS IN CONDITIONS OF DEINSTITUTIONALISATION
Authors: MUSIN E.R. ,   Federal State Budgetary Institution All-Russian Research Institute of Labor Protection and Economics of the Russian Ministry of Labor, Moscow, Russian Federation
Published: July 2024

The article examines the application of deinstitutionalisation policies in the field of orphanhood, characterized by prioritizing family-based care for children without parental care over institutional care. The relevance of this topic is driven by the need to reduce the level of social orphanhood and improve the quality of life of children without parental care living in stationary social institutions, and also reducing the time children spend in these organizations. The research objectives include: exploration of the legislative framework for providing social services to orphaned children and children without parental care; examination of the process of reforming organizations for orphaned children and innovations in their functioning; and quality assessment of social services provided in child assistance centers located in Volgograd Oblast. Theoretical research methods are applied in the article, specifically the study and analysis of literature and open sources, as well as deductive method. To evaluate the quality of the services provided, an independent quality assessment of service provision and the results of surveys of social service recipients in Volgograd child assistance centers were considered. The findings of the study can have practical application in the implementation of family-type living arrangements in organizations for orphaned children, including child assistance centers, which will improve the quality of social services provided to children and reduce prevalence of social orphanhood.
RESEARCH ON THE FUNCTIONS OF CHINA’S OPEN UNIVERSITY IN THE PERSPECTIVE OF LIFELONG EDUCATION
Authors: XIN SH. ,   Shanghai Putuo Sparetime University
Published: July 2024

Open universities are adult colleges and universities engaged in higher specialist and undergraduate qualification education, supported by modern information technology and using modern distance and open education as the main form. Open universities are generally found in county-level cities and above. Students enrolled in the program are generally those with qualifications from ordinary high schools, vocational high schools, amateur high schools, junior colleges, technical schools, vocational schools or equivalent. The programs are comprehensive, with advanced teaching facilities and strong teaching staff. Open education is an important form of lifelong education and an important way to promote the comprehensive quality of all people. Open universities continue to build open, flexible, convenient and efficient learning platforms, break the time, geographical and spatial constraints, make full use of modern long-distance information technology, and improve the “cloud” resources, so that people can learn at any time, any place, independently and conveniently, which plays an important role in the construction of a lifelong learning system and in the improvement of the comprehensive quality of all people. In recent years, the national open university system has adhered to the principles of “people-oriented, community-based, integrated and coordinated, and reform-led”, focusing on co-ordination and collaboration, giving full play to the leading role of the open universities, focusing on policy guidance, focusing on the development of special features, and joining hands with all kinds of educational resources to build open and diversified channels for the supply of academic education, vocational skills training for employment and entrepreneurship, elderly education for effective services, and off-campus education for young people in a multi-dimensional and accurate way, which will surely result in more achievements in the future in the fields of open academic education, vocational education, community education, and elderly education, and so forth.
A POSSIBLE MECHANISM OF THE OPTICAL QUANTUM TUNNELING EFFECT IN PHOTOCATALYSTS BASED ON NANOSTRUCTURED FUNCTIONAL CERAMICS
Authors: RAKHIMOV R.KH. ,   Institute of Materials Science of the SPA “Physics-Sun” of the Academy of Science of Uzbekistan, Tashkent, Republic of Uzbekistan,   Institute of Renewable Energy Sources
Published: July 2024

The article examines the proposed mechanism of optical tunneling effect, which explains the property of functional ceramics to convert solar energy into pulses in the infrared range. It is suggested that the incident radiation is absorbed by ceramic particles, exciting lattice vibrations known as phonons. As phonons accumulate, they transition to a higher energy state, generating infrared photons. The key role is played by the presence of a rising edge of the radiation pulse, which determines the wavelength of the pulses regardless of the wavelength of the infrared energy carrier. As a result, the infrared energy “tunnels” into mediums that are typically opaque to infrared radiation. This mechanism, based on the vibrational nature of ceramics and the wave properties of radiation, explains the unique ability of functional ceramics to convert energy into pulsed radiation with a specific wavelength. The proposed model has a wide range of applications in various fields, including industry, energy, and agriculture.
MODELING OF THE CHOICE OF SOLUTIONS TO MANAGEMENT TASKS WHEN EXTINGUISHING A FIRE IN UNDERGROUND STRUCTURES
Authors: ANIKIN S.N. ,   State Fire Academy of Emercom of Russia, Moscow, Russian Federation, DANILOV M.M. , DENISOV A.N. , KOROLEV P.S.
Published: July 2024

The article deals with the problem of the theoretical foundations of management in organizational systems. The modeling of the choice of managerial alternatives for extinguishing a fire in underground structures is presented based on the comparison of real and forecast values by the fire extinguishing manager (ranking the conditions for choosing managerial alternatives), while ranking the conditions for choosing managerial alternatives is carried out using a graphoanalytic approach. The solution of the tasks set during the planning of actions is shown by modeling GERT networks. An urgent issue is and remains the possibility of choosing a decisive direction, taking into account the comparison of real and forecast results of fire extinguishing actions, in the case when the criteria of the current situation may be a variety of possible acceptable options. Results. An approach to the selection of management alternatives for fire extinguishing in underground structures has been developed based on the comparison of real and forecast values by the fire extinguishing manager based on the results of the application of the network planning method and the method of graphical evaluation and analysis of systems, a comprehensive analysis of the solution of the problem based on the identification of boundary conditions of fire extinguishing has been developed, a model for solving management problems during combat operations to extinguish a fire has been developed. The application of the developed model is relevant not only for the analysis of potential scenarios for planning and implementing combat operations to extinguish a fire in underground structures, but also for modeling the process of managing an organizational fire extinguishing system in boundary conditions of fire extinguishing in underground structures of high extent and area. This work is intended for those who make managerial decisions and manage forces and means when extinguishing fires.
ACTIVITIES OF THE ENTENTE MILITARY MISSIONS IN LATVIA IN 1919
Authors: ZAZERSKAYA TATIANA G. ,   Russian State University for the Humanities, Moscow, Russian Federation
Published: July 2024

Purpose of the study. The article examines the balance of forces that developed in the territory of today’s Latvia after the end of the First World War. The purpose of the article is to study the political situation in 1919 and the military operations between German volunteer units, Landeswehr, Red Army troops, White Guard formations, national armies of Latvia and Estonia. Under these conditions, the Entente countries, led by France and Great Britain, assumed a leading role in solving the German question and the subsequent evacuation of the remaining German formations after the Great War. For this purpose, several military missions of allied countries were sent to Latvia in 1919. Conclusions. As a result of the study, the author concludes that each of the victorious countries in the Great War considered itself entitled to determine the fate of small nations that had received the right to self-determination. While French diplomacy was not in a hurry to recognize Latvia internationally, hoping for the revival of «democratic» Russia, which would return the Baltic provinces to its fold, Great Britain prioritized its economic interests in the Baltic Sea and was ready to take Latvia under its control.
SVERDLOVSK AND PERM RAILWAYS IN 1941-1945: PATRIOTIC MOVEMENT OF URAL RAILWAY WORKERS
Authors: SPERANSKY ANDREY V. ,   Institute of History and Archeology of the Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russian Federation
Published: July 2024

The paper analyses the level of socio-political consciousness of workers of the Sverdlovsk and Perm railways during the Great Patriotic War. The paper shows that Ural railway workers made a significant contribution to the process of forming an indissoluble unity of the front and rear, both by achieving high production indicators and by actively participating in the patriotic movement. The paper also provides a detailed description of participation of railway workers in their free time in subbotnik (Saturday clean-up) and voskresnik (Sunday clean-up), in raising funds for the Defence Fund, in sending warm clothes and gifts for front-line soldiers, and in helping areas of the USSR liberated from the German occupiers. The paper focuses on the formation of special-purpose trains as an important area of military-patriotic activity of the Ural railway workers during the Great Patriotic War. In addition, the paper notes that armoured trains, military sanitary trains and bath trains, created during off-duty hours with money received because of patriotic events, were the necessary material embodiment of gratuitous support for soldiers and commanders of the Red Army from home front workers. The paper concludes that the high level of ideological and political motivation of employees of the Sverdlovsk and Perm railways contributed to their effective work, bringing victory over the hated enemy closer.
DOMESTIC VIOLENCE AS A CRIMINAL LAW PHENOMENON
Authors: YATSELENKO BORIS V. ,   All-Russian State University of Justice (RLA of the Ministry of Justice of Russia), Moscow, Russian Federation, UTKINA ALINA V.
Published: July 2024

The topic under consideration has always been and remains relevant in the context of modern realities, in particular, because domestic violence has a latent character compared to other types of crimes, and meanwhile, carries no less social danger. Domestic violence is a gaping hole not only in the social sphere of our society, but also in the legal one. In particular, in the field of criminal law, there is still a gap in the regulation of domestic violence, ways to fill which are proposed in this article.
ON INTERACTIVE SOLUTION FOR TWO POINT FUZZY BOUNDARY VALUE PROBLEM
Authors: Ceylan Tahir
Published: July 2024

In this manuscript, the eigenvalues and eigenfunctions of the twopoint
fuzzy boundary value problem (FBVP) are analyzed under the concept of
interactivity between the fuzzy numbers found in the boundary conditions. A
fuzzy solution is provided for this problem via sup-J extension, which can be
seen as a generalization of Zadeh’s extension principle. Finally, an example is
presented in order to compare the given features.
EVOLUÇÃO DA LEGISLAÇÃO AMBIENTAL NA GESTÃO DOS RESÍDUOS SÓLIDOS E A IMPORTÂNCIA DAS COOPERATIVAS E DOS CATADORES DE MATERIAIS RECICLÁVEIS NO MUNICÍPIO DE LONDRINA
Authors: Zanardi Otávio Zucoli , Grizio-Orita Edinéia Vilanova , Sartor Maria José , Negri Paulo Sérgio
Published: July 2024

O presente artigo analisa e busca compreender a evolução histórica das discussões e ordenamento jurídico sobre a preservação ambiental e resíduos sólidos, bem como o papel das cooperativas de catadores nos processos da gestão municipal dos resíduos. Evidenciou-se um importante papel das Conferências Internacionais sobre Meio Ambiente, que influenciaram as políticas de governo acerca da conservação dos recursos naturais, assim como nos processos de gestão dos resíduos sólidos. Buscou-se compreender sobre as cooperativas de catadores e sua relação com o sistema de coleta pública de resíduos, bem como sua importância para o sistema de coleta seletiva e reciclagem dos resíduos. A metodologia do trabalho desenvolvido baseou-se na revisão bibliográfica que possibilitou uma compreensão dos esforços empreendidos pelo ordenamento jurídico em diferentes esferas de competências para a proteção socioambiental.
ESTUDO DE VIABILIDADE DO PLANO DE GERENCIAMENTO DE RESÍDUOS SÓLIDOS DA UNESPAR – CAMPUS DE CAMPO MOURÃO
Authors: Freitas Júnior José Augusto de , Cardoso Oséias , Crispim Jefferson de Queiroz , Henrique Luiz Fernando Ferreira
Published: July 2024

A gestão de um Campus universitário depende de trabalho e planejamento em diferentes aspectos, o manejo dos resíduos sólidos tem papel fundamental, considerando o contexto da sustentabilidade ambiental. A pesquisa tem como proposta estudar o manejo dos resíduos sólidos da UNESPAR - Campus de Campo Mourão, uma vez que a instituição tem um papel fundamental por ser geradora de resíduos sólidos e possível disseminadora de boas práticas associadas a questão ambiental. O objetivo foi elaborar a proposta do Plano de Gerenciamento de Resíduos Sólidos - PGRS para o Campus, definindo normas e procedimentos para garantir que as atividades associadas ao manejo de resíduos desenvolvidas neste espaço de ensino, não venham afetar a saúde pública ou degradar o meio ambiente. Portanto, foram realizados estudos associados à legislação ambiental, levantamento bibliográfico e documental, mesmo como a verificação de trabalhos anteriores sobre o manejo de resíduos do Campus, visitas e contato com responsáveis pelo manejo dos resíduos, proporcionando levantamento de dados e compreensão da situação atual da instituição. A partir das informações adquiridas foram indicadas alternativas de segregação, acondicionamento, armazenamento, coleta, transporte, destinação e disposição final ambientalmente adequada.
Differential effects of areca nut, tobacco, and lime on oral squamous cell carcinoma progression
Authors: Verma Tarun Prakash , Adhikari Sonali , Kandpal Meenakshi , Jha Hem Chandra
Published: July 2024

Background

Consumption of tobacco and its associated products has been linked with a high incidence of oral cancer in the Indian subcontinent. The present study aims to assess the differential effects of areca nut, tobacco, and slaked lime on the pathogenesis and progression of oral cancer.

Methodology

Extracts of areca nut (ANE), tobacco leaf (TLE), and lime water (LWE) were prepared and characterized. Oral keratinocyte cells (BICR10) were treated with the prepared extracts alone and in combinations. Cell apoptosis, necrosis, nuclear aberrations, and transcript expression profiles were assessed to study the cancer pathogenesis.

Results

An increase in apoptosis and necrosis was observed in the cells treated with ANE and ANE+LWE, while a decrease in apoptosis was observed in cells treated with TLE. We also found a variation in the size of nuclei and an increase in the number of multinuclei in the cells treated with TLE and TLE+LWE. Out of 24 head and neck cancer-related genes, we found significant upregulation in seven genes in ANE, six in ANE+LWE, 13 in TLE, 20 in LWE, and 14 in TLE+LWE treated cells. On pathway enrichment analysis, there were alterations in the “pathways in cancer,” “focal adhesion,” and “amoebiasis.”

Conclusion

Although areca nut has been regarded as a carcinogen, its carcinogenic potential is lesser than tobacco and lime. Moreover, adjunctive use of tobacco and lime along with areca nut may be an essential factor in the onset and progression of oral cancer.
Investigation of differentially expressed genes related to cellular senescence between high-risk and non-high-risk groups in neuroblastoma
Authors: Zhou Xingyu , Wu Yuying , Qin Lan , Zeng Miao , Zhang Mingying , Zhang Jun
Published: July 2024

Object

This study aims to identify differentially expressed genes (DEGs) between high-risk and non-high-risk groups in neuroblastoma (NB), construct a prognostic model, and establish a risk score formula.

Materials and methods

The NB dataset GSE49710 (n = 498) from the GEO database served as the training cohort to select DEGs between high-risk and non-high-risk NB groups. Cellular senescence-related genes were obtained from the Aging Atlas database. Intersection genes from both datasets were identified as key genes of cellular senescence-related genes (SRGs). A prognostic model was constructed using Univariate Cox regression analysis and the Lasso algorithm with SRGs. Validation was performed using the E-MTAB-8248 cohort (n = 223). The expression levels of AURKA and CENPA were evaluated via RT-qPCR in two clinical NB sample groups.

Results

Eight SRGs were identified, and a prognostic model comprising five genes related to cellular senescence was constructed. AURKA and CENPA showed significant expression in clinical samples and were closely associated with cellular senescence.

Conclusion

The prognostic model consisted with five cellular senescence related genes effectively predicts the prognosis of NB patients. AURKA and CENPA represent promising targets in NB for predicting cellular senescence, offering potential insights for NB therapy.
Quantification of soil organic carbon: the challenge of biochar-induced spatial heterogeneity
Authors: Lotz Simon , Bucheli Thomas D. , Schmidt Hans-Peter , Hagemann Nikolas
Published: July 2024

Introduction

Soil organic carbon (SOC) content can vary significantly across a given plot. Therefore, a representative sampling is a prerequisite to obtain meaningful results from analysis and of utter importance when SOC quantification is used to quantify (temporary) carbon dioxide removal (CDR). However, certain management practices aiming to increase SOC further increase the level of heterogeneity and may challenge representative sampling schemes. This includes concentrated root-zone application of biochar, which immediately increases SOC with the input of biochar-C and may promote the local enrichment of non-biochar SOC over time.

Methods

Here, we used numerical modelling to quantify the number of single sampling points (soil cores) needed to achieve a representative sample of biochar-C and total SOC on a plot after application of biochar in rows, e.g., for growing vegetables, or in the circumference of trees in agroforestry systems.

Results

After row application of 5 t ha−1 biochar in soil with rather low SOC content (26 t ha−1), 140 soil cores (per 0.25 ha plot) where necessary to achieve representative sampling of C-stocks (±5% error) in 90% of the repeated sampling simulation cases. Compared to realistic and cost-effective soil sampling scenarios in agronomic practice, we conclude that concentrated root zone application of biochar makes representative sampling for quantification of SOC in soils with low baseline C-stocks virtually impossible.

Discussion

This finding calls into question the soil-sampling and SOC-analysis-based (“result-based”) monitoring of SOC as a (temporary) CDR when biochar might have been applied. Considering the rapid scaling of biochar production and use in agriculture, this is a considerable challenge for SOC certification. Instead, action-based incentives, rewarding farmers for carrying out specific practices, could be applied to promote carbon farming practices.
An experimental research of the influence on critical heat flux of a rod bundle under certain inlet temperatures
Authors: Duan Minghui , Zhao Minfu , Wei Junhan , Xu Yongwang
Published: July 2024

Critical heat flux (CHF) is one of the most concerned thermal hydraulic phenomena in reactor safety analysis. It involves complex two-phase flow heat transfer mechanism, and has not been fully understood, so the prediction of critical heat flux mainly depends on CHF correlations obtained under limited experimental conditions. At present, CHF correlations are generally developed with pressure, mass flux and quality as key independent variables. And correspondingly, the test matrix of a CHF test consists of the above parameters. However, it is impossible to perform CHF tests accurately according to the predetermined quality. In CIAE, a CHF experimental research of a 5 × 5 uniformly heated rod bundle has been carried out. In the experiment, the inlet temperature of the test section was directly taken as a parameter in the test matrix. The CHF data were achieved by stepwise increasing the heating power. The test conditions covered the pressure of 2.8–15.5 MPa, the mass flux of 845–3533 kg/(m2·s), and the inlet temperature of 100°C–300°C. The test data have been analyzed to obtain the thermal-hydraulic parameter influences on CHF by taking the inlet temperature as a variable. The results indicated that, within the test condition range, under the same inlet temperatures, CHF was hardly affected by pressure, and linearly increased with the increasing mass flux. With the increase of inlet temperature, the enhancement of CHF with the increasing mass flux gradually weakens. And CHF was linearly decreased with the increasing inlet temperature under the same mass flux. By contrast, the parameter influences on CHF were more complex by taking the local quality as a variable. According to the research, it can be concluded that, it has an advantage of simplifying the CHF correlation form to take the inlet temperature of the test section as a variable parameter. The research can provide new ideas for CHF experiment, data analysis and correlation development.
Knowledge mapping and evolutionary analysis of energy storage resource management under renewable energy uncertainty: a bibliometric analysis
Authors: Li Zhenyu , Pu Han , Li Tiezhi
Published: July 2024

The research on energy storage resource management is an important measure to cope with the present problem of uncertainty in the use of renewable energy, in order to explore the evolution of the research focus and future trend of energy storage resource management under the uncertainty of renewable energy, this paper adopts the method of bibliometric analysis, and conducts a visual analysis of the relevant 800 documents in the core collection of the Web of Science by using the CiteSpace to draw co-occurrence maps and analyze the collaborative networks of different countries/regions, institutions and authors in this field, and further conducted journal co-citation analysis, literature co-citation analysis and author co-citation analysis. The keyword co-occurrence, emergent analysis, and cluster co-occurrence analysis reveal the current research focus and trend in this field, and summarize and propose four future key focus directions: energy storage technology improvement, energy storage system integration, expansion of business models for energy storage resource management, and intelligent control of energy storage system, which provide new research paths for solving the problem of renewable energy uncertainty in the future.
New energy power system inertia weak position evaluation and frequency monitoring positioning
Authors: Liu Jiaji , Di Peng
Published: July 2024

The high proportion of new energy into the power grid leads to a significant uneven distribution trend of the inertia of the power grid, which seriously affects the safe and stable operation of the power grid. It is urgent to carry out the inertia evaluation of the new energy power system. In view of the insufficient accuracy of the equivalent inertia evaluation method of a single inertia center in evaluating large-scale power systems, this paper first proposed the equivalent inertia evaluation method of new energy power system in the region, and proposed the evaluation index of network area inertia to reveal the weak inertia network area. Secondly, for the inertia evaluation of new energy power system nodes, monitoring devices should be installed at each bus node. As the system construction cost is too high, a node inertia evaluation model of new energy power system is established to reduce the number of monitoring devices installed. Finally, in view of the unclear basis and inaccurate location of the frequency monitoring node selection model in the evaluation of equivalent inertia, a correlation model of equivalent inertia and node inertia is established to characterize the correlation between any node inertia and system equivalent inertia in the system. The consistency of the position of the equivalent inertia evaluation frequency monitoring node and the maximum inertia node of the system was derived, and the accuracy of the maximum inertia node as a frequency monitoring node was verified by the inertia center method and the frequency center method.
A pest image recognition method for long-tail distribution problem
Authors: Chen Shengbo , Gao Quan , He Yun
Published: July 2024

Deep learning has revolutionized numerous fields, notably image classification. However, conventional methods in agricultural pest recognition struggle with the long-tail distribution of pest image data, characterized by limited samples in rare pest categories, thereby impeding overall model performance. This study proposes two state-of-the-art techniques: Instance-based Data Augmentation (IDA) and Constraint-based Feature Tuning (CFT). IDA collaboratively applies resampling and mixup methods to notably enhance feature extraction for rare class images. This approach addresses the long-tail distribution challenge through resampling, ensuring adequate representation for scarce categories. Additionally, by introducing data augmentation, we further refined the recognition of tail-end categories without compromising performance on common samples. CFT, a refinement built upon pre-trained models using IDA, facilitated the precise classification of image features through fine-tuning. Our experimental findings validate that our proposed method outperformed previous approaches on the CIFAR-10-LT, CIFAR-100-LT, and IP102 datasets, demonstrating its effectiveness. Using IDA and CFT to optimize the ViT model, we observed significant improvements over the baseline, with accuracy rates reaching 98.21%, 88.62%, and 64.26%, representing increases of 0.74%, 3.55%, and 5.73% respectively. Our evaluation of the CIFAR-10-LT and CIFAR-100-LT datasets also demonstrated state-of-the-art performance.
Preimplantation genetic testing for complex chromosomal rearrangements: clinical outcomes and potential risk factors
Authors: Liu Dun , Chen Chuangqi , Huang Qianwen , Dong Yunqiao , Xu Liqing , Dong Mei , Zhu Zhenghong , Huang Li , Wang Fang , Zhang Lijia , Zhang Xiqian , Liu Fenghua
Published: July 2024

Objective

Complex chromosome rearrangements (CCR) are rare structural abnormalities involving at least three breakpoints, categorized into three types based on their structure: type A (three-way rearrangements), type B (double two-way translocations), and type C (exceptional CCR). However, thus far, limited data exists on preimplantation genetic testing for chromosomal structural rearrangements (PGT-SR) in CCR carriers. This study aims to evaluate the clinical outcomes and influencing factors of PGT-SR in couples with CCR.

Methods

Fifteen couples with unique CCR recruited from 793 couples following PGT-SR between January 2017 and May 2023. In addition, a total of 54 CCR cases, 39 previously reported as well as 15 newly added, were included in the analysis of factors associate with normal/balanced embryos.

Results

A total of 100 blastocysts were biopsied and analyzed in 15 CCR couples after 17 PGT-SR cycles, with 16.0% being euploid, 78.0% aneuploid and 6.0% mosaic. 11 normal/balanced embryos and one mosaic embryo were transferred, resulting in eight live births. Furthermore, based on the combined data from 54 CCR carriers, the proportion of normal/balanced embryos was 10.8%, with a significant decrease observed among female carriers compared to male heterozygotes (6.5% vs. 15.5%, p = 0.002). Type B exhibited the lowest rate of euploid embryos at only 6.7%, followed by type A at 11.6% and type C at 14.0%, although the differences were not significant (p = 0.182). After completing the multivariate generalized estimating equation (GEE) analysis, type B (p = 0.014) and female carrier (p = 0.002) were identified as independent risk factors for fewer euploid embryos.

Conclusion

The occurrence of balanced CCR in patients with reproductive abnormalities may be more frequent than we expected. Despite the proportion of normal/balanced embryos being significantly low, which can be influenced by CCR type and carrier’s sex, PGT-SR may improve the reproductive outcomes among CCR cases. These findings can optimize the clinical management and genetic counseling of CCR carriers seeking assisted reproductive technology (ART).