bluuebunny/crossref_metadata_2025 huggingface dataset:
Study effect of weather conditions on the allegro-inflammatory factors and clinical symptoms of allergic rhinitis
Authors: Yonghua Shen , Nasab Entezar Mehrabi , Liuo Yen
Published: June 2022

Purpose: Allergic rhinitis (AR) is one of the allergic diseases that initiated by T helper lymphocyte (Th)2 immune response and mediators are main reason of clinical symptoms. In the genetically predisposed AR patients, environmental factors are main triggers of allergic reactions. Therefore, effects of climate conditions (warm, cold, humid and dry) on allergic rhinitis were evaluated.Methods: AR model was produced in mice under the four different conditions. Then, Clinical symptoms (sneezing and nasal rubbing), total immunoglobulin (Ig)E, histamine, interleukin (IL)-4 leukotriene (LT)B4, LTC4 levels and gene expression of CysLT1R, HRH1, and MUC5a were studied.Results: Nasal rubbing, histamine level, expression of MUC5a and HRH1 genes in the AR-C, sneezing in the AR-D, LTB4 and LTC4 levels and expression of CysLT1R gene in the AR-W groups were significantly (P<0.05) increased compared to the AR group. The levels of total IgE and IL-4 had no significant changes (P>0.05). Conclusions: Air temperature and humidity had effect on AR pathophysiology and, weather conditions can be an important factor in control of AR.
A Comparative Study of Positive and Negative Electronic Word-of-Mouth on the SERVQUAL Scale under the COVID-19 epidemic -Taking a Regional Teaching Hospital in Taiwan as an Example
Authors: Lee Po-Chun , Liang Li-Lin , Huang Min-Hsin , Huang Ching-Yuan
Published: June 2022

Background
In recent years, studies have disclosed that electronic WOM (eWOM) more directly reflects consumers' post-purchase psychological perception, and directly affects repurchase behavior, which is valued by institutions in various fields. Within the scope of service characteristic evaluation, medical service is the most invisible and difficult to evaluate service attribute. They are service organizations that must have high trust attributes. Therefore, the eWOM review will significantly influence people's decision-making process for choosing a healthcare provider. The purpose of this research is to combine eWOM reviews with the SERVQUAL scale in a comparative study of positive and negative eWOM reviews of a certain regional teaching hospital in Taiwan.
Methods
This research obtained data of eWOM reviews publicly available on Google maps from a Regional Teaching hospital in Taiwan in the past 10 years (from June 24, 2011, to December 31, 2021) by using website scraping technology. The semantic content analysis method was used in this study to classify WOM reviews according to the revised PZB SERVQUAL scale.
Results
Statistical analysis is then conducted. During the COVID-19 pandemic, the positive reviews have shown a downward trend. Among the five determiners of SERVQUAL of PZB, positive WOM reviews performed best in “Assurance”, with a positive review rate of 60.00%, followed by 42.11% of “Reliability”. In negative WOM reviews, “Assurance” performed the worst, with a positive rate of 72.34%, followed by “Responsiveness” at 28.37% and “Reliability” at 26.95%.
Conclusion
Since the onset of the COVID-19 in 2020, negative eWOM has increased significantly and exceeded the numbers of positive eWOM. Regardless of the positive and negative reviews, what patients care most about is “Assurance” of the professional attitude and skills of the medical staff, which needs to be strengthened most urgently. In addition, good “Reliability” will help to build up positive eWOM. However, the "Responsiveness" of poor service waiting time can easily lead to the spread of negative eWOM. This study suggests that the hospital management should focus on these few service-oriented qualities.
Evaluation & Testing of Emission on Sargassum wightii Based Flash Powder Composition
Authors: Gnanavel Jawahar Raj Sivanandha , Vignesh Nagarajan Jawahar
Published: June 2022

Environmental pollution is one of the major concerns leading to the rise in the temperature of the earth's surface. Owing to this serious concern, many countries in the world are facing so many environmental disasters every year. Hence, it becomes the need of the hour to act immediately to reduce environmental pollution so that the future becomes safer. Fireworks form an integral part of the Indian Subcontinent in almost all the festivals and cultural rituals. This results in the emission of a huge amount of various toxic fumes that directly affect the environmental purity of the air. The objective of the current research work focuses on the reduction of pollution caused due to the emission from burning fireworks. One of the important ingredients used in pyrotechnics is flash powder. The traditional flash powder composition contains aluminium powder as fuel, potassium nitrate as an oxidizer and Sulphur as an igniter at defined levels. To reduce the impact of toxic emissions in flash powder, an organic compound like Sargassum wightii brown seaweed powder is used as a replacement at prescribed levels and the experimentation is carried out. It is found that the Sulphur weightage in the flash powder composition can be replaced up to 50% with the Sargassum wightii brown seaweed powder without affecting the traditional performance of the flash powder. To study the emissions taking place in the flash powder composition, a specially designed flash powder emission testing chamber has been developed. Upon testing, it is evident that the flash powder composition with Sargassum wightii showed that there is a reduction in toxic emission upto 21% on the modified flash powder. This helps in generating cleaner emission and leads to attain greener pyrotechnics norms.
Development of a Classification Model for Physiological Parameters in Relation to Ecological Aspects Based on Cohort Data
Authors: Pimpale Yogita , Gupta Sachin
Published: June 2022

The ecological aspects such as environmental factors, socio economic constraints and demographic parameters are one of the key aspects to examine the health benefits of human subject and used as ready reference in eco system modelling. Presently, there are various kinds of deadly diseases and disorders who are liable for affecting the human health and impacting the eco framework of whole world. The virus such as Corona, Swine Flu, omicron and others are one of the best examples for the research community to understand the vulnerability of human health in relation to these unpredictable causes. As per report of world health organization every year more than ten million people are affected by such ecological and environmental disbalance. The impact of environmental factors on the functioning of several organs in humans appears to be significant. There is a need to understand this ecological model in relation to health of human subjects. In this study, a cohort-based data set of Ecological pollutants and Physiological signals such as ECG and anthropogenic data of human subjects were extracted from Maharashtra from 2015 to 2021. As per neural network-based hazard ratio was calculated and observed to be deplorable among unhealthy and health categories of human subjects. It has been concluded that the accumulative eco system is responsible for overburden to organs of living beings and policy makers must focus on the facts of study for modern management framework designs.
Spatial and temporal dynamics of air quality on the Red Sea – Application of satellite observations and back trajectory analysis
Authors: Mitra Bijoy , Hridoy Al-Ekram Elahee , Mahmud Khaled , Uddin Mohammed Sakib , Talha Abu , Das Nayan , Nath Sajib Kumar , Rahman Muhammad Muhitur , Rahman Syed Masiur
Published: June 2022

The Red Sea, lying between Asia and Africa, is a significant eco-region and the habitat of many marine species. It is an essential route for marine transportation, and it also provides many ecosystem services. Therefore, assessing the spatial and temporal distributions of air quality parameters over the Red Sea and assess temporal trends is important. This study investigated observations of multiple satellites to collect different meteorological and tropospheric columns of aerosols, trace gas including carbon monoxide (CO), nitrogen dioxide (NO2), sulfur dioxide (SO2), and ozone (O3), and meteorological data. The tropospheric columns of trace gases and aerosol index exhibit seasonal and regional characteristics over the Red Sea. The correlation coefficient for air pollutants (NO2, SO2, and O3) and meteorological parameters showed a positive medium and low correlation, whereas a negative correlation was found between O3, Aerosol Index (AI), and wind speed. The back trajectory transport of air mass component using Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) model showed long-range trajectory pattern. AI, trace gases concentrations, and meteorological data were investigated through Principal Component Analysis (PCA) with varimax rotation to find a discerning relationship and co-variance between air pollutants and meteorological data. This showed a relationship between meteorological data and CO and O3. Although the satellite observations have some inherent limitations compared to in-situ measurements, this study provides an overall landscape of air pollution over the Red Sea, which will benefit policymakers and researchers.
Liquid Water on Cold Exo-Earths via Basal Melting of Ice Sheets
Authors: Ojha Lujendra , Troncone Bryce , Buffo Jacob , Journaux Baptiste , McDonald George
Published: June 2022

Liquid water is a critical component of habitability. However, the production and stability of surficial liquid water can be challenging on planets devoid of adequate greenhouse warming. On such cold, icy exo-Earths, basal melting of regional/global ice sheets by geothermal heat provides an alternative means of forming liquid water. Here, we model the thermophysical evolution of ice sheets to ascertain the geophysical conditions that allow liquid water to be produced and maintained at temperatures above freezing on exo-Earths. We show that even with modest, Moon-like geothermal heat, subglacial oceans of liquid water can form at the base of and within the ice sheets on exo-Earths. Furthermore, subglacial oceans may persist on exo-Earths for a prolonged period due to the billion-year half-lives of the heat-producing elements responsible for geothermal heat. These subglacial oceans, often in contact with the planet’s crust and shielded from the high energy radiation of their parent star by thick ice layers, may provide habitable conditions for an extended period.
Injectable decellularized cartilage matrix hydrogel encapsulating urine-derived stem cells for immunomodulatory and cartilage defect regeneration
Authors: Shen Bin , Zeng Junfeng , Huang Liping , Xiong Huazhang , Li Qianjin , Wu Chenyu , Huang Yizhou , Xie Huiqi
Published: June 2022

Reconstruction of complex cartilage defects has remained a great challenge for tissue engineering due to the lack of stem cells and chronic inflammation within the joint. In this study, we have developed an injectable pig cartilage-derived decellularized extracellular matrix (dECM) hydrogels for the repair of cartilage defects, which has shown sound biocompatibility and immunomodulatory capacity both in vitro and in vivo. The dECM hydrogels can enhance the chondrogenic differentiation of human urine-derived stem cells (USCs). As shown by in vitro experiment, the USCs in the dECM hydrogels have survived, proliferated, and produced a mass of cartilage-specific extracellular matrix containing collagen II and aggrecan. And the USCs-laden dECM hydrogels have shown the capacity to promote the secretion of extracellular matrix, modulate the immune response and promote cartilage regeneration in the rat model for cartilage defect.
A retrospective evaluation of short-term results from colonic stenting as a bridge to elective surgery versus emergency surgery for malignant intestinal obstruction
Authors: Chongjing Mu , Lei Chen
Published: June 2022

Purpose: The efficacy and safety of self-expanding metallic stent (SEMS) placement as a bridge to elective surgery versus emergency surgery to treat malignant intestinal obstruction is debated. This study aimed to evaluate the outcomes of patients with malignant intestinal obstruction treated using different procedure. Methods: Subjects admitted to the authors’ department with colonic obstruction (n = 87) were studied. They underwent colonic stenting as a bridge to elective surgery (SEMS group: n = 14) or emergency surgery (ES group:n=22).Their demographic characteristics, stoma rate, laparoscopy rate and postoperative complications were analyzed, and the potential risk factors of postoperative complications and the optimal time interval from SEMS implantation to elective surgery were explored. Results: The stoma rate was 15% in the SEMS group versus 60 % in the ES group (P = 0.02), and the postoperative complication rate was 8% in the SEMS group versus 40% in the ES group (P = 0.04). The proportion of patients undergoing laparoscopy in SEMS group was significantly higher than that in ES group (69% vs. 15%; P = 0.003).The effect of ASA grade on postoperative complications was statistically significant (OR = 24.6; P = 0.008). The Receiving operating characteristic(ROC) curve could not determine the optimal time interval between SEMS implantation and elective surgery (AUC = 0.466).Conclusions:SEMS implantation has the advantages of lower temporary stoma rate, less postoperative complications and higher laparoscopy rate compared with ES in the treatment of left malignant intestinal obstruction. ASA grade is a risk factor for postoperative complications. However, larger sample size prospective randomized controlled trials(RCT) are still needed to confirm long-term oncological outcomes.
Theory of optical axion electrodynamics and application to the Kerr effect in topological antiferromagnets
Authors: Ahn Junyeong , Vishwanath Ashvin , Xu Su-Yang
Published: June 2022

Electromagnetic fields in a magneto-electric medium behave in close analogy to photons coupled to the hypothetical elementary particle, the axion. This emergent axion electrodynamics is expected to provide novel ways to detect and control material properties with electromagnetic fields. Despite having been studied intensively for over a decade, its theoretical understanding remains mostly confined to the static limit. Formulating axion electrodynamics at general optical frequencies requires resolving the difficulty of calculating optical magneto-electric coupling in periodic systems and demands a proper generalization of the axion field. Here, we introduce a theory of optical axion electrodynamics. We define the proper optical axion magneto-electric coupling through its relation to optical surface Hall conductivity and provide ways to calculate it in quasi-two-dimensional and three-dimensional lattice systems. By employing our new formulae, we show that optical axion electrodynamics can lead to a significant Kerr effect but vanishing Faraday effect in fully compensated antiferromagnets, refuting the conventional wisdom that the Kerr effect is a measure of the net magnetic moment. Our work sets the foundation for a concrete understanding of the axion magneto-optic effects and opens up a promising route to studying antiferromagnetism with light. Our theory is particularly relevant to materials like MnBi$_2$Te$_4$, a topological antiferromagnet whose mageto electric response is shown here to be dominated by the axion contribution even at optical frequencies.
HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma
Authors: Garrett Matthew C. , Albano Rebecca , Carnwath Troy , Elahi Lubayna , Behrman Catherine , Pemberton Merissa , Woo Daniel , O’Brien Eric , VanCauwenbergh Brett , Perentesis John , Shah Sanjit , Hagan Matthew , Kendler Ady , Zhao Chuntao , Plas Dave , Paranjpe Aditi , Roskin Krishna , Kornblum Harley , Lu Richard
Published: June 2022

Introduction: Low-grade and secondary high-grade gliomas frequently contain a mutation in the IDH1 metabolic enzyme that is hypothesized to drive tumorigenesis by inhibiting many of the chromatin-regulating enzymes that regulate DNA structure. Much of the previous research has focused on DNA methylation leaving histone modifications relatively under-studied. Histone deacetylase inhibitors are promising anti-cancer agents and have already been used in clinical trials, however a clear understanding of their mechanism or gene targets is lacking. In this study, the authors genetically dissect patient-derived IDH1 mutant cultures to determine which HDAC enzymes drive growth in IDH1 mutant gliomas and what are the down-stream gene targets. This information will allow clinicians to design more specific HDAC inhibitors as well as monitor for treatment response. Methods: A panel of patient-derived gliomasphere cell lines (2 IDH1 mutant lines, 3 IDH1 wildtype lines) were subjected to a drug-screen of 110 epigenetic modifying drugs from 34 different epigenetic classes. The effect of LBH (Panobinostat) on gene expression and chromatin structure was tested on patient-derived IDH1 mutant lines. The role of each of the highly expressed HDAC enzymes was molecularly dissected using lentiviral RNA interference knock-down vectors and a patient-derived IDH1 mutant in vitro model of glioblastoma (HK252). These results were then confirmed in an in vivo xenotransplant model (BT-142). Results: The IDH1 mutation leads to gene down-regulation, DNA hypermethylation, increased DNA accessibility and H3K27 hypo-acetylation in two distinct IDH1 mutant over-expression models. The drug screen identified histone deacetylase inhibitors (HDACi) and Panobinostat (LBH) more specifically as the most selective compounds to inhibit growth in IDH1 mutant glioma lines. Of the eleven annotated HDAC enzymes (HDAC1-11) only six are expressed in IDH1 mutant glioma tissue samples and patient-derived gliomasphere lines (HDAC1, HDAC2, HDAC3, HDAC4, HDAC6, HDAC9). Lentiviral knock-down experiments revealed that HDAC1 and HDAC6 are the most consistently essential for growth both in vitro and in vivo and target very different gene modules. Knock-down of HDAC1 or HDAC6 in vivo led to a more circumscribed less invasive tumor. Conclusions: The gene dysregulation induced by the IDH1 mutation is wide-spread and only partially reversible by direct IDH1 inhibition. This study reports a previously under-described phenomenon of histone deacetylation induced by the IDH1 mutant enzyme and identifies HDAC1 and HDAC6 as important and drug-targetable enzymes that are necessary for growth and invasiveness in IDH1 mutant gliomas.
Unusual cause of Long QT in a young man
Authors: Mazzanti Camilla , Ferrari Valeria , Galastri Silvia , Martelletti Paolo , De Biase Luciano
Published: June 2022

Several conditions may be responsible for long QT syndrome, among which electrolyte disturbances play a major role, particularly hypopotassemia and hypomagnesemia. Although the causes can be countless, it is good practice to always perform an accurate anamnesis, a thorough physical examination and targeted laboratory tests. Gitelman Syndrome is one of the rare disorders that could manifest with these electrolyte alterations. It is a hereditary tubulopathy which impairs the kidney’s ability to reabsorb salt resulting in hypokalemia, hypomagnesemia, metabolic alkalosis and increased urinary potassium excretion. We report the case of an 18-year-old boy, almost asymptomatic, with a persistent prolongation of QT interval diagnosed by ECG during a sport medical examination. Genetic analysis did not identify any gene related to known Long QT syndromes. To complete the diagnostic process a dynamic ECG and a stress test were also carried out to evaluate any ventricular arrhythmia, a possible fatal consequence of QT prolongation. Echocardiogram did not show any structural abnormality. Laboratory tests performed fit all the criteria for Gitelman syndrome. Amiloride and a specific diet with magnesium and potassium integration were prescribed and resulted in a shortening of the QT interval, a normalization of the kaliemia and a reduction of the asthenia.
QTL mapping for bacterial leaf blight resistance in RIL’s derived from Danteshwari x Dagad Deshi
Authors: Kumar Indra , KOSHARIYA ASHOK , Baral Deewakar , Kotasthane Anil S
Published: June 2022

In ”present study, quantitative trait loci (QTL) analysis was carried out using SSR HvSSR markers in F7 recombinant inbred lines derived from a cross between two potential indica genotypes, Danteshwari and Dagad Deshi”. A recombinant inbred line (RIL) population consisting of 122 lines was constructed from a cross between Danteshwari a high yielding popular rice cultivar and Dagad Deshi a tall deep rooted poor yielder”. “Six QTL’s were identified on chromosome1, 5, & 9 for bacterial blight tolerance” and explained 0.17% - 8.24% phenotypic variation at LOD value of > 2.5. “Three QTL’s were on CH# 1 (marker interval RM259 to RM243, RM572 to 58.61 cM and RM3825 to 147.21 cM), one on CH#5 (marker interval RM188 to 101.01cM) and two on CH#9 (marker interval HvSSR937 to 67.61 cM, and RM242 to RM278) which influenced lesion length”. “QTL influencing lesion length with positive additive effect” (one) “and negative additive effects” (05) were “identified indicating” that “alleles at these loci are being contributed by either of the parents respectively”.
Accuracy of an image-free handheld hip navigation device for total hip arthroplasty in a lateral decubitus position
Authors: Naito Yohei , Hasegawa Masahiro , Tone Shine , Wakabayashi Hiroki , Sudo Akihiro
Published: June 2022

Background: Portable navigation systems have been developed for use in total hip arthroplasty (THA) in recent years. The purpose of this study was to investigate the accuracy of cup insertion in primary THA using an image-free handheld navigation device in the lateral decubitus position.Methods: This retrospective study included 68 consecutive cementless THAs performed using an image-free handheld navigation device and 68 consecutive THAs performed without a navigation system as historical controls. All cases underwent THAs in a lateral decubitus position. Postoperative cup radiographic inclination and radiographic anteversion were assessed, and the accuracy of cup insertion was compared between the two groups. Navigation error was also assessed.Results: The mean absolute errors of the postoperative measured inclination from the target inclination were 3.9° ± 2.2° in the navigation group and 8.5° ± 6.9° in the control group (p<0.001). The mean absolute errors of anteversion were 4.8° ± 3.5° in the navigation group and 11.4° ± 6.6° in the control group (p<0.001). The percentage of cups inside Lewinnek’s safe zone was 94% in the navigation group and 37% in the control group (p<0.001). The mean absolute values of navigation error were 3.1° ± 2.1° in inclination and 4.2° ± 2.8° in anteversion. No factors affected the navigation errors.Conclusions: Use of an image-free handheld navigation device can improve the accuracy of cup insertion compared with conventional manual technique in THA in the lateral decubitus position.
The Stock Correlation Network Model and Its Influencing Factors in China's Green Finance Market
Authors: Ma Qianting , Zhao Jiaxin , Ji Xiaoyang , Shi Junchi , Chen Xi
Published: June 2022

Green finance is a significant step to achieving environmentally sustainable development in the context of carbon neutrality. Based on the perspective of the stock correlation network, we select 51 green and environmental protection enterprises and construct the stock correlation network model in China's green financial market according to the correlation of their stock price fluctuations. On this basis, it discusses its network topologies and its dynamic evolution characteristics. After that, it deeply studies its impact mechanism of systemically importance in China's green financial market and introduces the major green financial policies for comparative analysis. In the light of empirical research, we can obtain the following results. First, the stock size distribution in China's green financial market has a power-law tail. Second, a sharp drop in the market index will increase the aggregation of the stock correlation network in the green financial market. Third, the variables about corporate social responsibility, corporate R&D investment intensity, and corporate green innovation output play significant roles in promoting the individual companies’ systemically importance ranking in the stock correlation networks of China’s green financial market. Fourth, the implementation of major green financial policies has promoted the improvement of the systematic importance of state-owned enterprises. Finally, the research enriches the application research of complex network theory in the green financial market and provides practical guidance for regulators to strengthen the risk monitoring of the green financial market.
Polyamide membrane pretreatment combined with UPLC–MS/MS for the determination of industrial dyes in grain and meat products
Authors: He Yahui , Liu Xinyu , Zhu Yao , Liu Yajie , Li Lu , Wang Jing , El-Aty A. M. Abd
Published: June 2022

Herein, ultra-performance liquid chromatography-tandem four-stage mass spectrometry (UPLC–MS/MS) combined with a novel polyamide membrane extraction was used to rapidly determine industrial dyes in grain and meat products. Polyamide was used as an adsorbent in the membrane. When the sample was treated by the polyamide membrane, the industrial dyes were absorbed by the N-propyl Ethylenediamine (PSA) into the polyamide membrane, while most other ingredients were passed through the membrane. Then, the industrial dyes were eluted from the polyamide membrane by different solvents to be analyzed by UPLC–MS/MS. The novel pretreat method will reduce the time of the whole process to less than 30 minutes. The recovery of the dye was between 71% and 126%, and the precision was between 3 and 13. The results showed that the polyamide membrane can be used as a pretreatment method for detecting multicomponent industrial dyes in grain and meat products, which is rapid, simple, reliable and accurate.
A Novel Hybrid Intelligence Framework using Harmony Search and Quick ABC (HS-qABC) for OCL Constraint Based Testing
Authors: Dharmalingam Jeya Mala , Abraham Pradeep Reynold
Published: June 2022

Exploring testing possibilities at an early software life cycle is becoming increasingly necessary to improve the reliability of a system. It facilitates the removal of most of the errors at the earliest, thereby avoiding propagation of defects to the subsequent phases. Constraint-Based Testing (CBT) is a prominent form of functional testing approach that can be performed at the earliest. The efficiency of CBT can be improved by combining it with the Search Based Testing (SBT) technique, in which case SBT can be used to produce test suites while the constraints can be used to guide the test case generation process. Hence, the proposed work combines OCL (Object Constraint Language) and hybrid Harmony Search – Quick Artificial Bee Colony (HS-qABC) algorithm to generate efficient test cases. Furthermore, a novel predicate-based fitness function named as exit-predicate-wise branch coverage (EPWBC) is defined to evaluate the generated test data. The experimental results indicate that OCL constraint-based testing adopting hybrid HS-qABC algorithm forms an excellent combination to produce more test coverage and optimal test suite. Furthermore, it has been inferred that hybrid HS-qABC algorithm outperforms the other search approaches in test suite optimization.
The Motivational Power of Ideas in Institutions and Collective Action
Authors: Kestler Thomas
Published: June 2022

Ideational institutionalism has by now largely established itself as a ‘fourth new institutionalism’. However, while the assertion that ‘ideas matter’ is widely shared, ideational institutionalists are still struggling with the question how ideas matter, especially in motivational terms. The role of ideas not just as switchmen, but as genuine drivers of collective action still lacks theoretical underpinning. This article aims at closing this gap. It elaborates a theoretical model to explain how ideas shift the structure of motivation from the individual to the collective level. Borrowing from motivational psychology and social philosophy, especially from the work of John Searle, two crucial mechanisms are explicated. The first one is imagination, a specific mental state that allows collectivizing the intentional structure of beliefs and affords a sense of self-efficacy in collective contexts. The second one is plural self-awareness, a mechanism that shifts intentions-to-act to the collective level by detaching instentional control from bodily awareness.
Fusing Asynchronous Event and Synchronization Frame Data with Multi-layer Feature Attention Guided Filtering
Authors: Zhang Shixiong , Wang Wenmin , Li Honglei , Zhang Shenyong
Published: June 2022

As novel bio-inspired sensors, event cameras have advantages in motion scenes due to their unique construction principle. Compared with standard cameras, event cameras can effectively avoid the challenges of motion blur and low dynamic range in capturing moving objects. Event cameras can provide high-speed asynchronous visual data with high dynamics, high time resolution, and low redundancy. Therefore, event data can effectively overcome the shortcomings of conventional frames in challenging moving scenes. In this paper, we introduce an efficient fusion of asyn-chronous event data and synchronized frame data using the two-scale decomposition: base and detail layers, and an attention network designed to focus on the features of the fused data. Our approach effectively integrates the advantages of event cameras and traditional frame cameras by providing a dual-modality vision. Through our fusion strategy, frame data can be enhanced and repaired by event data under various challenges. Specially, we perform an effective evaluation of the fused data, including the objective evaluation and testing on object detection tasks. Experimental results show that our method exceeds the accuracy of using only a single data model, compared to other state-of-the-art methods, our approach yields better accuracy and robustness.
Comparative Analysis of Machine Learning Algorithms in Breast Cancer Classification
Authors: Chaurasiya Satish , Rajak Ranjit
Published: June 2022

Now days breast cancer has emerged as a diseases effecting women to suffer a life threating phase and eventually lead to death world wide. The prediction of breast cancer in woman at the initial stage can aggrandize recovery and chance of abidance considerably as the essential medical treatments can be adapted on time and stop its further growth. Moreover the precise categorization of tumor eliminates the avoidable treatments and patients skips from witnessing the medical emergencies. Thus the exact categorization of breast cancer either benign or malignant and the precised analysis of each is a matter of important exploration. Machine learning have extensively beneficial aspects in critical feature extraction from the breast cancer dataset. Thus the machine learning can be astronomically honored as a alternative methodology in breast cancer pattern categorization and forecast modeling. In this paper ML techniques namely Support vector machines (SVM), logistic Regression, Random forest tree (RDT) and k-nearest neighbours (k-Nns) are over viewed and later performance measures compared for breast cancer analysis and prognosis.
Bisphosphonates Fight Against Cancer Roots: Zoledronic Acid Targets Chemo-Resistant Polyploid Giant Cancer Cells
Authors: Adibi Rezvan , Moein Shiva , Gheisari Yousof
Published: June 2022

Although polyploid giant cancer cells (PGCCs) are known as a key source of failure of current therapies, sufficient drugs to target these cells are not yet introduced. Considering the similarities of polyploid cells in regeneration and cancer, we hypothesized that zoledronic acid (ZA), an osteoclast-targeting agent, might be used to eliminate PGCCs. The 5637-bladder cancer cell line was treated with various doses of cisplatin to enrich polyploid cells and the efficacy of different concentrations of ZA in reducing this population was assessed. The metabolic profile of PGCCs was investigated with gas chromatography-mass spectrometry. Lipid profiles, mitochondrial density, and ROS content were also measured to assess the response of the cells to ZA. Cancer cells surviving after three days of exposure with 6 μM cisplatin were mainly polyploid. These cells demonstrated special morphological features such as fusion with diploid or other polyploid cells and originated in daughter cells through budding. ZA could substantially eradicate PGCCs with the maximal effect observed with 50 μM which resulted in the drop of PGCC fraction from 60±7.5% to 19±1.7%. PGCCs enriched after cisplatin demonstrated a drastic metabolic shift compared to untreated cancer cells with an augmentation of lipids. Further assays confirmed the high content of lipid droplets and cholesterol in these cells which were reduced after ZA administration. Additionally, the mitochondrial density and ROS increased in PGCCs both of which declined in response to ZA. Taken together, we propose that ZA is a potent inhibitor of PGCCs which modulates the significant metabolic alteration of PGCCs. Although this drug has been successfully exploited as adjuvant therapy for some malignancies, the current evidence on its effects on PGCCs justifies further trials to assess its potency for improving the success of current therapies. For tackling tumor resistance and relapse.
Socio-Economic Inequalities in Health-Related Quality of Life Among Iranian Adolescents: Application of Health Equity Assessment Toolkit Running title: Socio-Economic Inequalities & Health-Related Quality of Life
Authors: Maleki Azam , Faghihzadeh Elham , Youseflu Samaneh , Zamani Shahnaz
Published: June 2022

Background: One of the main concerns of public health is increasing inequality of health status, which has an adverse effect on people's life. Purpose: The current study aims to analyze the role of socioeconomic inequalities in health-related quality of life (QoL) among Iranian adolescents. Methods: A cross-sectional descriptive study was conducted on 576 adolescents aged 15 to 18 years. The samples were selected using the Multi-stage sampling method. Data were collected by a demographic checklist, and KIDSCREEN-52 questionnaire and analyzed by SPSS ver.16. The Health Equity Assessment Toolkit (HEAT) Version 4.0 (beta) was used to assess adolescents' QoL inequalities in terms of socio-economic subgroups. Results: The results show that 27.2 adolescents had low quality of life. The score of physical and autonomy components of QoL was significantly more in male versus school environment in female students. Also, the asset index, father's, and mother's education, and family income in female students, and the assets and family income in male students were significantly related to the quality of life (p<0.05). The risk of lower QOL in the poorest quintile was 1.12 times more than in the richest quintile. The consideration index of Asset in terms of sex was 4.5 and the modified Gini index was more than 0.5 in females and males. Conclusion: Our findings highlight the significant effects of socioeconomic inequality on HRQL of Iranian adolescents. Requires a targeted policy approach to reach the poorest quintile for improving the quality of life of adolescents.
Blood biomarkers for occupational hand-arm vibration exposure
Authors: Vihlborg Per , Lundberg Oscar , Pettersson-Pablo Paul , Johansson Niclas , Bryngelsson Ing-liss , Graff pål
Published: June 2022

INTRODUCTIONHand-arm vibration is a common occupational exposure that causes neurological impairment, myalgia and vibration induced Raynaud’s phenomena or vibration white fingers. The pathological mechanism is largely unknown, though several mechanisms have been proposed, involving both immunological vascular damage and defective neural responses.AIMThe aim of this study is to test whether the substances IL-33, MDC, IL-10, ET-1, CCL20, calcitonin and TXA2 change in exposed individuals before and after occupation hand-arm vibration exposure.MethodThirty-eight full-time shift workers exposed to hand-arm vibration were recruited. All the participants underwent medical examinations regarding symptoms of Raynaud’s phenomena. The concentration of IL-33, MDC, IL-10, ET-1, CCL20, calcitonin and TXA2 was tested before and after a workday. ResultThere was a significant increase in ET-1 and calcitonin concentration after the work shift. There was also a significant decrease in CCL20 concentration. Moreover, there was significant increase in MDC after the work shift in those exposed to vibration white fingers. Lastly, MDC was statistically significant lower before a work shift (p=0.023) in the vibration white finger group compared to the non-vibration white finger group. ConclusionExposure to occupational hand-arm vibration is associated with changes in ET-1 and calcitonin concentrations and MDC is increased in participates suffering from vibration white fingers, suggesting a role in the pathophysiology.
Fabrication and Investigation of New TiO2/Amino Acids Modified Chitosan For Methylene Blue Removal Via Adsorption and Photodegradation
Authors: Fathana Haya , Rahmi Rahmi , Lubis Surya , Adlim Muhammad , Muktaridha Omar , Iqhramullah Muhammad
Published: June 2022

Modification of chitosan using amino acids (AA) obtained from the protein hydrolysis process of tofu wastewater (TW) and TiO2 had been successfully prepared and applied in methylene blue (MB) removal from aqueous solutions. Based on the XRD results, the addition of AA and TiO2 slightly changed the crystallinity properties of chitosan. FT-IR results confirmed the formation of Chitosan-amino acid/TiO2 films (CATF). The results of TGA and DSC showed that the addition of AA decreased the thermal stability of the film, but the addition of TiO2 was able to increase the thermal stability of the film. The addition of AA and TiO2 to chitosan improved the mechanical characteristics of chitosan, according to the tensile strength data. Based on the adsorption kinetics, the removal of MB followed a pseudo second order model (PSO). The isotherm model in the adsorption process follows the Langmuir isotherm model and the maximum adsorption capacity is 64.95 mg/g. Based on the regeneration test, the CATF could be regenerated.
Report of a rare case of primary malignant mesothelioma of the perineum presenting as a scrotal abscess
Authors: Li Zhiwei , Zhu Qiqi , Xiao Kaibing , Xiao Zhiyang , Yang Pang
Published: June 2022

A 57-year-old man presented with erythema and pain in the scrotum for 1 week, with pus exuding from the ruptured scrotum for 1 day. Physical examination showed an enlarged left scrotum, with a small area of ruptured skin, and yellowish-white discharge from the rupture was visible in the lower posterior part of the testes near the perineum, with slightly high local skin temperature, tenderness, and fluctuating sensation. The initial reproductive system ultrasound and pelvic CT were suggestive of inflammatory infection, which was confirmed by histology following two surgeries . The patient's condition did not show improvement for a long period of time, and repeat pelvic CT suggested multiple enlarged inguinal lymph nodes. Fine needle aspiration cytology suggested metastatic cancer.Histopathological examination and immunohistochemistry of the perineal scrotal area showed malignant mesothelioma, and whole-body PET-CT suggested pulmonary metastases and invasion into the surrounding tissues, such as the organs of the reproductive system. The patient received chemotherapy and immunotherapy, but the disease progressed rapidly, and he ultimately died of respiratory failure.
Genome sequence and characterization of Streptomyces phage Pablito, representing a new species within the genus Janusvirus
Authors: Ongenae Véronique , Azeredo Joana , Kropinski Andrew M. , Rozen Daniel , Briegel Ariane , Claessen Dennis
Published: June 2022

Streptomycetes are ubiquitous soil bacteria. Here we report the complete and annotated genome sequence and characterization of Streptomyces phage Pablito, isolated from a soil sample in Haarlem, the Netherlands using Streptomyces lividans as host. This phage was able to infect a diverse range of Streptomyces strains, but none belonging to the sister genus Kitasatospora. Phage Pablito has double-stranded DNA with a genome length of 49,581 base pairs encoding 76 putative proteins, of which 26 could be predicted. The presence of a serine integrase protein indicated the lysogenic nature of phage Pablito. The phage remained stable over a wide range of temperatures (25 – 45°C) and at pH ≥ 7.0, but lost infectivity at temperatures above 55°C or when the pH dropped below 6.0. This newly isolated phage is closely related to Streptomyces phage Janus and Hank144 and considered a new species classified in the genus Janusvirus, within the subfamily Arquattrovirinae.
Decomposition of higher-order nonlinear S-boxes in lightweight block
ciphers for algebraic fault analysis
Authors: Fang Xing , Zhang Hongxin , Cui Xiaotong , Fan Fan
Published: June 2022

Nowadays, with the development of Internet of Things and information security technologies, lightweight block ciphers are gradually being widely used. As a sidechannel attack method, algebraic fault analysis has received attention from experts and scholars since its introduction. The only nonlinear operation in lightweight block ciphers is S box substitution, and the performance index of S box directly determines the security strength of the cipher.In order to further improve the efficiency of algebraic fault analysis, this paper proposes a method to rewrite the algebraic equations of S box substitution by decomposing the original cubic S boxes into two quadratic S boxes. The results show that this method is significantly effective compared to the original method in GIFT 64 and SKINNY 64, especially in SKINNY 64 block cipher, where the average solving time is reduced by several hundred times in the best case with the same samples. At the same time, the need for the number of faults is reduced, and at least 2 faulty ciphertexts can be used to recover the master key. In addition, the PRESENT 64 block cipher is also studied in this paper, and the results show that the method can also improve the efficiency significantly when the number of fault injection rounds is deep.
The Modeling and Cascade Sliding Mode Control of a Moving Mass Actuated Coaxial Dual-Rotor UAV
Authors: Siling Wang , SIchen Ji , Kun Yan , Yang Zhou
Published: June 2022

In this paper, a three-track moving mass control mechanism-based attitude control scheme is proposed to address the problems of overcomplicated rotor components and low reliability of the coaxial dual-rotor UAV. The motion and aerodynamic models of the moving mass-actuated ducted coaxial dual-rotor UAV are derived. The rotation dynamic characteristics of a Moving Mass-Actuated UAV (MAUAV) with different slider positions and mass ratios are analyzed. Aiming at the MAUAV rotation’s nonlinearity and uncertainty, the attitude controller based on Backstepping Sliding Mode Control (BSMC) is designed. On that basis, we developed the position controller using Cascade Sliding Mode Control (CSMC). The simulation results demonstrate that the designed attitude controller had a fast response speed and a small steady-state error in the attitude tracking experiment. Additionally, the designed position controller had a better trajectory tracking effect under different levels of gust disturbance compared with the Linear Quadratic Regulator (LQR) control-based position controller.
An optical and chemiluminescence assay for assessing the cytotoxicity of Balamuthia mandrillaris against human neurospheroids
Authors: Pengsart Worakamol , Kulkeaw Kasem
Published: June 2022

A spheroid is a cell aggregate in a three-dimensional context; thereby, it recapitulates the cellular architecture in human tissue. However, the utility of spheroids as an assay for host-parasite interactions remains unproven. This study demonstrates the potential use of neurospheroids for assessing the cytotoxicity of the life-threatening pathogenic amoeba Balamuthia mandrillaris. The neuroblastoma SH-SY5Y cells formed a spheroid in a hanging drop of culture medium. Cellular damage of B. mandrillaris trophozoites on human neuronal spheroids was observed using microscopic imaging and ATP detection. B. mandrillaris trophozoites rapidly caused a decrease in ATP production in the spheroid, leading to loss of neurospheroid integrity. Moreover, 3D confocal microscopy imaging revealed interactions between the trophozoites and SH-SY5Y neuronal cells in the outer layer of the neurospheroid. In conclusion, the neurospheroid allows the assessment of host cell damage in a simple and quantitative manner.
Study on land use and landscape pattern change in the Huai River Ecological and Economic Zone from 2000 to 2020
Authors: You Mou , Zou Zeduo , Zhao Wei , Fu Canfang , Zhang Wenwen , He Zhixiao
Published: June 2022

Exploring the relationship between land use change and landscape patterns can provide a basis for regional ecological management. In this paper, based on remote sensing images of the Huai River Ecological and Economic Zone for the years 2000, 2005, 2010, 2015 and 2020, the spatial and temporal evolution patterns of land use in the region were quantitatively described by using the methods of land use shift matrix and landscape pattern analysis. The relationship between land use change and landscape pattern was analyzed with the Grey Relation Analysis (GRA) model. The results show that: (1) the land use of the Huai River Ecological and Economic Zone has changed significantly in the past 20 years, with the conversion of arable land into construction and forest lands, in addition to the growth of water areas and a decline in the areas of arable land, grassland and unused land. (2) The landscape pattern fragmentation of each type of land in the study area from 2000 to 2020 fluctuated and decreased, and the landscape connectivity and landscape diversity increased significantly. (3) The GRA model shows that construction, arable and forest lands played the most significant role in the change of landscape pattern of the Huai River Ecological and Economic Zone. Countermeasures are proposed to better coordinate and optimize the relationship between spatial development and landscape pattern for the Huai River ecological and economic Zone.
Bibliometric study of obtaining furfural and hydroxymethyl furfural from sugarcane bagasse
Authors: Murillo Sandra Peña , Nevárez Eddie Zambrano , Durango Eduardo Arango
Published: June 2022

This electronic document is a bibliometric observational study describing the production of furfural and hydroxymethylfurfural from sugarcane bagasse during 2015-2021 and was used as the primary measure, with the magazine, year of publication, first/last author, workplace, and autonomous community as the direct measures. Subsequently, articles were classified according to their content or research area. The impact factor was obtained from the Scopus and VoS Viewer bibliometric analysis. The results are presented in various figures. Through the search criteria used, 639 documents were retrieved in the 2015-2021 six-year term, excluding 307 because they did not correspond to affiliation with centers or institutions directly related to papers related to furfural and hydroxymethylfurfural. A total of 49 documents were selected, and an increase in interest in studying these compounds was verified in the research and the journals in which they were published. Most studies have been published in universities or research centers, and differences were observed in the volume of international and national scientific production, making it necessary to increase these investigations in Colombia.