bluuebunny/crossref_metadata_2025 huggingface dataset:
A local community detection algorithm based on potential community exploration
Authors: Wang Shenglong , Yang Jing , Ding Xiaoyu , Zhang Jianpei , Zhao Meng
Published: February 2023

Local community detection aims to detect local communities that have expanded from the given node. Because of the convenience of obtaining the local information of the network and nearly linear time complexity, researchers have proposed many local community detection algorithms to discover the community structure of real-world networks and have obtained excellent results. Most existing local community detection algorithms expand from the given node to a community based on an expansion mechanism that can determine the membership of nodes. However, when determining the membership of neighboring nodes of a community, previous algorithms only considered the impact from the current community, but the impact from the potential communities around the node was neglected. As the name implies, a potential community is a community structure hidden in an unexplored network around a node. This paper gives the definition of potential communities of a node for the first time, that is, a series of connected components consisting of the node’s neighbors that are in the unexplored network. We propose a three-stage local expansion algorithm, named LCDPC, that performs Local Community Detection based on Potential Community exploration. First, we search for a suitable node to replace the given node as the seed by calculating the node importance and the node similarity. Second, we form the initial community by combining the seed and its suitable potential community. Finally, the eligible nodes are selected by comparing the similarities between potential communities and the expanding community and nodes and adding them to the initial community for community expansion. The proposed algorithm is compared with eight state-of-the-art algorithms on both real-world networks and artificial networks, and the experimental results show that the performance of the proposed algorithm is better than that of the comparison algorithms and that the application of potential community exploration can help identify the community structure of networks.
Fault diagnosis of sensor pulse signals based on improved energy fluctuation index and VMD
Authors: Liu Yuhu , Chen Xiaolong , Mao Yongfang , Chai Yi , Jiang Yutao
Published: February 2023

Variational mode decomposition (VMD) has been widely applied in sensors. However, the mode number and balance parameter seriously limit VMD application. To solve this problem, this study proposes a novel method, which combines an improved energy fluctuation index (IEFI) and modified VMD (MVMD). In the proposed method, IEFI provided better performance to resist interference from random impulses by considering the periodicity of fault feature components. Consequently, it is applied to determine the initial center frequency for MVMD, which fixed the problem of the mode number. Moreover, a novel balance parameter search strategy, which can adaptively determine the optimal balance parameter, is combined with MVMD whose stop condition is replaced by kurtosis to extract the fault feature. Simulation results indicated that the proposed method does well in detecting the feature of a periodic impulse signal from the signal polluted by some interference impulses. Moreover, the bearing fault diagnosis results demonstrate that the proposed method can accurately detect bearing fault features. Furthermore, the method was validated with bearing fault data. The results showed that the method can accurately extract the fault characteristics of the impulse signal and achieve fault diagnosis.
Variability and genetic merits of white Guinea yam landraces in Nigeria
Authors: Agre Paterne A. , Edemodu Alex , Obidiegwu Jude E. , Adebola Patrick , Asiedu Robert , Asfaw Asrat
Published: February 2023

Introduction

Landraces represent a significant gene pool of African cultivated white Guinea yam diversity. They could, therefore, serve as a potential donor of important traits such as resilience to stresses as well as food quality attributes that may be useful in modern yam breeding. This study assessed the pattern of genetic variability, quantitative trait loci (QTLs), alleles, and genetic merits of landraces, which could be exploited in breeding for more sustainable yam production in Africa.

Methods

A total of 86 white Guinea yam landraces representing the popular landraces in Nigeria alongside 16 elite clones were used for this study. The yam landraces were genotyped using 4,819 DArTseq SNP markers and profiled using key productivity and food quality traits.

Results and discussion

Genetic population structure through admixture and hierarchical clustering methods revealed the presence of three major genetic groups. Genome-wide association scan identified thirteen SNP markers associated with five key traits, suggesting that landraces constitute a source of valuable genes for productivity and food quality traits. Further dissection of their genetic merits in yam breeding using the Genomic Prediction of Cross Performance (GPCP) allowed identifying several landraces with high crossing merit for multiple traits. Thirteen landraces were identified as potential genitors to develop segregating progenies to improve multiple traits simultaneously for desired gains in yam breeding. Results of this study provide valuable insights into the patterns and the merits of local genetic diversity which can be utilized for identifying desirable genes and alleles of interest in yam breeding for Africa.
Adaptation and validity of the Trait Meta-Mood scale for Brazilian adolescents
Authors: Câmara Sheila Gonçalves , Carlotto Mary Sandra , Cabello Rosario , Fernández-Berrocal Pablo
Published: February 2023

The current study aimed to present the process of adaption and validity evidence of the Trait Meta-Mood Scale (TMMS-24) for the population of Brazilian school adolescents. The study included 4,681 students aged 10 to 19 years old, attending public schools in 12 cities in the state of Rio Grande do Sul, Brazil. According to the original scale, the exploratory and confirmatory factorial analyses indicated adequate fit indexes and satisfactory reliability for the model composed of 24 items and three factors (attention, clarity, and repair). The scale showed a significant positive correlation with life satisfaction and psychological well-being. The results reveal that the TMMS-24 is adequate for the assessment of emotional intelligence among Brazilian adolescents and may contribute to research and interventions regarding emotional competencies among this population.
Addiction and autonomy: Why emotional dysregulation in addiction impairs autonomy and why it matters
Authors: Henden Edmund
Published: February 2023

An important philosophical issue in the study of addiction is what difference the fact that a person is addicted makes to attributions of autonomy (and responsibility) to their drug-oriented behavior. In spite of accumulating evidence suggesting the role of emotional dysregulation in understanding addiction, it has received surprisingly little attention in the debate about this issue. I claim that, as a result, an important aspect of the autonomy impairment of many addicted individuals has been largely overlooked. A widely shared assumption in the philosophical literature is that for addiction to impair a person’s autonomy it has to make them (in some sense) take drugs against their will. So-called “willing addicts” are therefore usually seen as exempted from the autonomy impairment believed to characterize “unwilling addicts,” the latter being those who “truly want” to stop using drugs but find their attempts repeatedly derailed by failures of self-control. In this article, I argue that the association between addiction and emotional dysregulation shows why this assumption is false. Emotional dysregulation is not only consistent with the possibility that many addicts take drugs “willingly,” it supports the hypothesis that they use drugs because they truly want to. The article proposes an explanation for why emotional dysregulation should nevertheless be seen as an aspect of their loss of control and an important reason why they have impaired autonomy. I end by exploring some implications of this account for addict’s decision-making capacity when they are prescribed the drugs to which they are addicted.
Age differences in psychological distress during the COVID-19 pandemic: March 2020 – June 2021
Authors: Best Ryan , Strough JoNell , Bruine de Bruin Wändi
Published: February 2023

In March 2020, COVID-19 brought illness, lockdowns, and economic turmoil worldwide. Studies from March–April 2020 reported increased psychological distress, especially among younger (vs. older) adults. Here, we examine whether age differences persisted in a 29-wave longitudinal survey conducted with an American national life-span sample over the first 16 months of the pandemic. Socio-emotional selectivity theory (SST) predicts that older age will be consistently associated with lower psychological distress due to life-span changes in motivation, while the strength and vulnerability integration model (SAVI) posits that age differences in psychological distress will diminish under prolonged stress. We find that younger adults consistently reported more psychological distress than older adults, though age differences did decrease over time. Prior diagnosis with anxiety or depression additionally predicted greater psychological distress throughout the study, but did not moderate age differences. We discuss implications for psychological theories of aging and interventions to reduce psychological distress.
Reading bots: The implication of deep learning on guided reading
Authors: Huang Baorong , Dou Juhua , Zhao Hai
Published: February 2023

This study introduces the application of deep-learning technologies in automatically generating guidance for independent reading. The study explores and demonstrates how to incorporate the latest advances in deep-learning-based natural language processing technologies in the three reading stages, namely, the pre-reading stage, the while-reading stage, and the post-reading stage. As a result, the novel design and implementation of a prototype system based on deep learning technologies are presented. This system includes connections to prior knowledge with knowledge graphs and summary-based question generation, the breakdown of complex sentences with text simplification, and the auto-grading of readers' writing regarding their comprehension of the reading materials. Experiments on word sense disambiguation, named entity recognition and question generation with real-world materials in the prototype system show that the selected deep learning models on these tasks obtain favorable results, but there are still errors to be overcome before their direct usage in real-world applications. Based on the experiment results and the reported performance of the deep learning models on reading-related tasks, the study reveals the challenges and limitations of deep learning technologies, such as inadequate performance, domain transfer issues, and low explain ability, for future improvement.
Impact of tobacco smoke constituents on nicotine-seeking behavior in adolescent and adult male rats
Authors: Gellner Candice A. , Carreño Diana , Belluzzi James D. , Leslie Frances M.
Published: February 2023

Introduction

Given the rapid increase in teen vaping over recent years it is critical to understand mechanisms underlying addiction and relapse to tobacco use at this age. To evaluate the role of non-nicotine constituents in cigarette smoke, our lab has previously established a model of intravenous self-administration of aqueous cigarette smoke extract (CSE). We now compare the sensitivity of male adolescent and adult rats who have self-administered CSE or nicotine to reinstatement with the pharmacological stressor, yohimbine, with and without cues.

Methods

Adolescents and adults, aged postnatal day (P) 34 and 84, were tested for the effect of yohimbine (0–2.5 mg/kg) on plasma corticosterone levels to establish a dose that was an effective stressor at both ages. Separate groups of animals were trained to lever press for food before beginning 1-hour drug self-administration sessions for nicotine or CSE (15 μg/kg/infusion nicotine content). Once stable responding was reached, drug was removed, and behavior extinguished. Drug-seeking behavior was reinstated with yohimbine, cues, or a combination of yohimbine and cues.

Results

Although adolescents and adults showed different dose-responses for yohimbine-induced corticosterone release, a dose of 2.5 mg/kg increased stress hormone levels at both ages. Whereas both ages displayed similar responding for CSE and nicotine, adolescents self-administered more CSE and nicotine as compared to adults. Cues and cues + stress reinstated responding to a greater extent in animals that had self-administered CSE, regardless of age.

Discussion

These findings suggest that non-nicotine tobacco smoke constituents influence later but not earlier stages of addiction in both adolescent and adult male rats.
Pilot study suggests DNA methylation of the glucocorticoid receptor gene (NR3C1) is associated with MDMA-assisted therapy treatment response for severe PTSD
Authors: Lewis Candace R. , Tafur Joseph , Spencer Sophie , Green Joseph M. , Harrison Charlotte , Kelmendi Benjamin , Rabin David M. , Yehuda Rachel , Yazar-Klosinski Berra , Cahn Baruch Rael
Published: February 2023

Background

Previous research has demonstrated that epigenetic changes in specific hypothalamic-pituitary-adrenal (HPA) genes may predict successful psychotherapy in post-traumatic stress disorder (PTSD). A recent Phase 3 clinical trial reported high efficacy of 3,4-methylenedioxymethamphetamine (MDMA)-assisted therapy for treating patients with severe PTSD compared to a therapy with placebo group (NCT03537014). This raises important questions regarding potential mechanisms of MDMA-assisted therapy. In the present study, we examined epigenetic changes in three key HPA axis genes before and after MDMA and placebo with therapy. As a pilot sub-study to the parent clinical trial, we assessed potential HPA epigenetic predictors for treatment response with genomic DNA derived from saliva (MDMA, n = 16; placebo, n = 7). Methylation levels at all 259 CpG sites annotated to three HPA genes (CRHR1, FKBP5, and NR3C1) were assessed in relation to treatment response as measured by the Clinician-Administered PTSD Scale (CAPS-5; Total Severity Score). Second, group (MDMA vs. placebo) differences in methylation change were assessed for sites that predicted treatment response.

Results

Methylation change across groups significantly predicted symptom reduction on 37 of 259 CpG sites tested, with two sites surviving false discovery rate (FDR) correction. Further, the MDMA-treatment group showed more methylation change compared to placebo on one site of the NR3C1 gene.

Conclusion

The findings of this study suggest that therapy-related PTSD symptom improvements may be related to DNA methylation changes in HPA genes and such changes may be greater in those receiving MDMA-assisted therapy. These findings can be used to generate hypothesis driven analyses for future studies with larger cohorts.
Organ donation: Key factors influencing the younger generation's decision-making in China
Authors: Chen Xiulan , Wei Wei , Ai Weili
Published: February 2023

Background

The organ transplantation sector in China is facing a severe shortage of donors, and the organ donation rate needs to be increased. Since 2015, voluntary donation by citizens has become the only source of organs for transplantation in China. In recent years, there has been a relatively positive change in young people's attitudes toward organ donation after death. The aim of the study was to understand young people's perceptions and attitudes toward organ donation and the factors that influence them and can positively impact the promotion of organ donation.

Methods

By analyzing relevant literature and legal texts, we developed a questionnaire. Information was obtained through questionnaires and interviews, and 501 valid questionnaires were returned from the target group. A chi-square test was used to examine whether there were significant differences in the willingness to organ donation among young people with different characteristics. A factor analysis was used to investigate the main factors influencing the different attitudes of young people toward organ donation, and a one-way ANOVA was used to examine whether young people with different characteristics were affected differently by different factors.

Results

In our survey of young people aged 18–30 years, 99.2% of respondents knew about organ donation, 47.1% were willing to donate organs, and 15.2% understood that there were corresponding laws and regulations for organ donation. The study's findings showed that urban residents are more willing to be organ donators than rural residents; people with higher education levels have better awareness and are more willing to donate an organ; and people with religious beliefs are more likely to donate organs. The main factors that support the willingness of young people to donate are the social environment that provides support, their optimism in dealing with death, and their desire to realize their final value after death. The main factors for those unwilling to donate were low awareness or misconceptions about organ donation among individuals and their families and their attitudes toward death. As the people who took the questionnaire are probably interested in organ donation, the sample results will show a higher percentage of people who know about organ donation. We hope to discuss further with a larger and broader sample coverage to improve the estimates' validity and reflect the overall picture more accurately in a future study.

Conclusion

Young people knew about organ donation but had a low depth of awareness. Household registration type, education level, and religious affiliation significantly correlate with people's willingness to donate. The supportive environment for organ donation in society and the correct understanding of the organ donation process and laws and regulations can influence people's willingness to donate.
Case study of the Beijing 2022 Olympic Winter Games: Implications for global mass gathering events amidst the COVID-19 pandemic
Authors: Huo Da , Shen Ying , Zhou Tao , Yu Tong , Lyu Ruoran , Tong Ying , Gao Ting , Wang Quanyi
Published: February 2023

Objective

This study aimed to evaluate the public health countermeasures against coronavirus disease 2019 (COVID-19) that are important for organizing mass gathering events (MGEs) during a pandemic and to identify the practices suitable for application at future MGEs.

Methods

This study analyzed data from the Beijing 2022 Olympic Winter Games. The aforementioned analysis was conducted from the viewpoints of overseas stakeholders and Chinese residents. The comprehensive set of countermeasures established to prevent the transmission of the COVID-19 pandemic comprised the bubble strategy, the three-layer testing strategy (pre-departure testing, testing at the airport, and daily screening), the mandatory wearing of N95 masks, and mandatory vaccination.

Findings

A total of 437 positive cases within the bubble were reported during the Games, of which 60.6% were detected through screening at the airport and 39.4% were detected through routine screening. Nearly, 92.0% of the positive cases were detected within 7 days of arrival in China, and 80.8% of the cases had already been identified before the Opening Ceremony of the Games. Outside the bubble, no Games stakeholders were infected and no spectator contracted COVID-19. The bubble strategy, the three-layer testing strategy, the mandatory wearing of N95 masks, and mandatory vaccination are promising countermeasures to prevent the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during MGEs.

Conclusion

Public health countermeasures introduced during the Beijing 2022 Olympic Winter Games were proven to be useful. The success in delivering and organizing the Games instills confidence and leaves a public health legacy for future MGEs amid the pandemic of COVID-19 or future emerging infectious diseases.
Perceived social support and family members of patients with mental disorders: A mixed method study
Authors: Amini Shabnam , Jalali Amir , Jalali Rostam
Published: February 2023

Introduction

Family members are the caregivers to patients with mental disorders at home, and the mental and spiritual pressures caused by this responsibility necessitate physical, mental, and perceived social support for these families. The present mixed method study is an attempt to elaborate on the perceived social support by Iranian families of patients with chronic mental disorders.

Materials and methods

Using a sequential mixed method explanatory study (quantitative and qualitative), 200 family members of patients with chronic mental disorders were selected through convenient sampling (quantitative phase). Data gathering was started using a demographics form and Stewart and Sherburne's perceived social support scale. The qualitative phase included 10 participants who obtained low scores in the quantitative phase and took part in private, face-to-face, in-depth, and semi-structured interviews. The data obtained in the quantitative phase were analyzed using statistical tests, and the interviews were analyzed using qualitative content analysis.

Findings

The perceived social support by the participants was at a moderate level in different fields of tangible support, information and emotional support, kindness, and positive social interactions. The results of the qualitative phase revealed social support status in 15 subcategories, 6 categories, and 2 themes of support and acceptance by family, relatives, and friends, with support and being understood by society. The results of the qualitative and quantitative sections emphasized the needs of the patient's family members (who acted as caregivers for patients) for support in family, social, and emotional areas.

Conclusion

The family members of patients with chronic mental disorders have different needs in the area of perceived social support. Such needs are more tangible in family members such as children with mentally ill parents or parents with mentally ill children. The results of this study can be used for educational and supportive planning for caregivers of patients, most of whom are family members.
Schooltime's contribution to pupils' physical activity levels: A longitudinal study
Authors: Johansen Martine Amalie , Mikalsen Hilde Kristin , Lagestad Pål Arild
Published: February 2023

Introduction

Pupils spend a significant portion of their time at school. As a result, the school serves as an important setting for both learning and the formation of healthy behaviors. Many children, and even fewer young people, do not fulfill the (inter)national health recommendations of 60 minutes of moderate to vigorous physical activity (MVPA) per day. The aim of this study was to examine pupils' MVPA during schooltime in a longitudinal perspective, including the transition from primary to secondary school.

Methods

The MVPA of 234 pupils' was measured objectively using accelerometer monitors for seven consecutive days, in the spring of 2017, 2018, and 2019. Statistical analyses by Friedman, Wilcoxon and Mann–Whitney U-test were used to answer the research questions.

Results

The results showed a significant decrease in the pupils' MVPA and fulfilment of health recommendations during schooltime, from 7th to 8th grade. The analyses also showed that MVPA during schooltime was higher among boys than girls, and also contributed more to boys' fulfilment of the health recommendations at all three time periods.

Discussion

The results indicate that the transition between primary and secondary school is vulnerable concerning pupils' MVPA during schooltime. As schooltime accounted for significantly more MVPA for boys than for girls at all three time periods, we question whether physical activity is sufficiently facilitated for girls in school.
Revisiting the link between domain satisfaction and life satisfaction during the COVID-19 pandemic: Job-related moderators in triadic analysis in dual-earner parents with adolescent children
Authors: Schnettler Berta , Concha-Salgado Andrés , Orellana Ligia , Saracostti Mahia , Miranda-Zapata Edgardo , Poblete Héctor , Lobos Germán , Adasme-Berríos Cristian , Lapo María , Beroíza Katherine , Riquelme Leonor
Published: February 2023

Introduction

Research has evaluated the impact of COVID-19 pandemic and lockdowns on individuals' life satisfaction, but wellbeing interrelations between family members in this context have been less explored. This study examined the spillover and crossover effects of one parent's job satisfaction (JS), satisfaction with family life (SWFaL) and satisfaction with food-related life (SWFoL) on their own, their partner's, and their adolescent children's life satisfaction (LS), and the influence of adolescents' SWFaL and SWFoL on their own and their parents' LS, in dual-earner families with adolescents. The moderating role of job-related variables of both parents were also explored.

Methods

Questionnaires were administered to 860 dual-earner parents with adolescents in two cities in Chile during 2020. Mothers and fathers answered the Overall Job Satisfaction Scale and the three family members answered the Satisfaction with Life Scale, the Satisfaction with Family Life Scale and the Satisfaction with Food-related Life Scale.

Results

Using the Actor-Partner Interdependence Model and structural equation modeling, we found that fathers' LS was positively associated with their own JS, SWFaL and SWFoL (spillover), and negatively with adolescents' SWFoL (crossover). Likewise, mothers' LS was positively associated with their own JS, SWFaL and SWFoL (spillover), with fathers' and adolescents' SWFaL, and negatively with adolescents' SWFoL. Adolescents' LS was positively associated with their own SWFaL and SWFoL (spillover), and with their fathers' JS, and negatively with their fathers' SWFoL. JS showed gendered patterns in spillover and crossover associations. Parents' type of employment, mothers' working hours and city of residence moderated some spillover and crossover associations for father-mother and parent-adolescent dyads.

Discussion

These findings suggest that, for dual-earner parents with adolescents, improving individuals' LS requires interventions that should be carried out not individually, but at a family level.
Characteristics of full compensation and its association with total astigmatism: A cross-sectional study
Authors: Wu Ziyun , Hu Yuanyuan , Xu Zihang , Sun Wei , Wang Yirong , Shao Zhen , Liu Yi , Yu Mingkun , Si Peiran , Huo HuanHuan , Wang Xingrong , Bi Hongsheng
Published: February 2023

Objective

To evaluate the characteristics of full compensation and its association with the prevalence of total astigmatism (TA), and to analyze the effects of TA on uncorrected distance visual acuity (UDVA).

Methods

With random cluster sampling based on a school-based cross-sectional design, children aged 4 to 18 years were recruited in September 2020, Shandong Province, China. TA, anterior corneal astigmatism (ACA), and ocular residual astigmatism (ORA) were converted to vectorial components (J0, J45), followed by an assessment of the compensatory effect of ACA by ORA. Astigmatism was defined as a cylinder that was better than or equal to 0.75 diopters (D). Logistic regression analysis was used to assess the related factors for children with full compensation, and the generalized linear model was used to assess the influence of TA on UDVA.

Results

Out of 4,494 eligible children, data of 4,145 children (92.3%, 9.23 ± 3.15 years, 50.4% boys) were included in the statistical analysis. The prevalence of TA (27.9%) increased significantly with age (Ptrend < 0.001). The distribution of full compensation in J0 and J45 components were similar (22.1% and 25.6%, respectively), which decreased with age (Ptrend < 0.001). The closer the refractive status was to emmetropization, the higher the proportion of full compensation and the lower the prevalence of TA were. Shorter axial length (J0: Odds Ratio (OR) = 0.76, 95% confidence interval (CI): 0.61 to 0.94, P = 0.010), better UDVA (J0: OR = 0.37, 95% CI: 0.21 to 0.65, P < 0.001; J45: OR = 0.34, 95% CI: 0.20 to 0.59, P < 0.001), and longer average corneal curvature radius (J0: OR = 3.72, 95% CI: 2.18 to 6.34, P < 0.001; J45: OR = 2.82, 95% CI: 1.67 to 4.76, P < 0.001) were associated with full compensation. Higher TA was associated with a worse UDVA (β = 0.03, 95% CI: 0.02 to 0.04, P < 0.001).

Conclusions

The prevalence of TA gradually increased with age, and showed a U-shaped distribution with increased refraction. Full compensation was associated with smaller TA and better UDVA. This indicated that considering the compensatory effect of ORA is vital for astigmatism correction in clinical work, which may improve the visual quality.
Acupuncture for comorbid depression and insomnia in perimenopause: A feasibility patient-assessor-blinded, randomized, and sham-controlled clinical trial
Authors: Zhao Fei-Yi , Zheng Zhen , Fu Qiang-Qiang , Conduit Russell , Xu Hong , Wang Hui-Ru , Huang Yu-Ling , Jiang Ting , Zhang Wen-Jing , Kennedy Gerard A.
Published: February 2023

Background and objective

Whilst acupuncture is widely used for treating psychosomatic diseases, there is little high-quality evidence supporting its application in comorbid perimenopausal depression (PMD) and insomnia (PMI) which are common complaints during climacteric. This feasibility, patient-assessor-blinded, randomized, sham-controlled clinical trial addresses this gap by investigating the efficacy and safety of acupuncture on depressed mood and poor sleep in women with comorbid PMD and PMI.

Methods

Seventy eligible participants were randomly assigned to either real-acupuncture (RA) or sham-acupuncture (SA) groups. Either RA or SA treatment were delivered in 17 sessions over 8 weeks. The primary outcomes for mood and sleep were changes on 17-items Hamilton Depression Rating Scale (HAM-D17) and Pittsburgh Sleep Quality Index (PSQI) scores, from baseline to 16-week follow-up. Secondary outcome measures involved anxiety symptoms, perimenopausal symptoms, quality of life, participants' experience of and satisfaction with the acupuncture treatment. Blood samples were taken to measure reproductive hormone levels. Intention-To-Treat and Per-Protocol analyses were conducted with linear mixed-effects models. The James' and Bang's blinding indices were used to assess the adequacy of blinding.

Results

Sixty-five participants completed all treatment sessions, and 54 and 41 participants completed the eight- and 16-week follow-ups, respectively. At post-treatment and 8-week follow-up, the RA group showed a significantly greater reduction in PSQI scores than the SA group did; although the reduction of HAM-D17 scores in RA group was significant, the change was not statistically different from that of SA. There were no significant mean differences between baseline and 16-week follow-up in either HAM-D17 or PSQI in either group. There were no significant between-group differences in serum reproductive hormone levels. All treatments were tolerable and no serious adverse events were reported, and the blinding was successful.

Conclusion

Acupuncture is safe and can contribute to clinically relevant improvements in comorbid PMD and PMI, with satisfactory short-and medium-term effects. Whether the anti-depressive benefit of acupuncture is specific or non-specific remains to be determined. No evidence was found for any longer-term benefit of acupuncture compared to sham at 16 weeks. Further research is required to elucidate mechanisms underlying the short to medium term effects of acupuncture.
Impact of environmental comfort on urban vitality in small and medium-sized cities: A case study of Wuxi County in Chongqing, China
Authors: Liu Gaoxiang , Lei Jie , Qin Hongqiao , Niu Jiaqi , Chen Jianghua , Lu Jun , Han Guifeng
Published: February 2023

China's urbanization has exceeded 64% and a large number of small and medium-sized cities are the key development areas in the new stage. In urban planning, it is very important to reveal the influence of environmental comfort on urban vitality to improve the life quality of residents in these towns. Thus, the study investigated the impact of environmental comfort on urban vitality using ordinary least squares regression in Wuxi County. Environmental comfort was assessed through a comprehensive analysis of a built-up area and urban vitality was represented by vitality intensity. In addition, the influence pathways were identified and model validation was verified. The conclusions are as follows: (1) Environmental comfort and urban vitality are distributed spatially similarly, and both gradually decline from the center to the periphery. It is high in the east and low in the west, high in the south and low in the north. (2) Population density, POI mixing degree, building density, and road network density have significant positive effects on urban vitality. Population density has the greatest impact on urban vitality. Building height, building age, and river buffer have significant negative effects on urban vitality. (3) The impact of comprehensive environmental comfort on urban vitality is positive, and in terms of time, the order of impact is afternoon > morning > evening. Finally, a method for assessing the impact of environmental comfort on urban vitality was constructed, and the promoting effect of environmental comfort improvements on the vitality was verified. These findings will fill the gap between urban physical space and social needs in planning practices and provide reference to improve vitality for urban planning in small and medium-sized cities.
Assessment of radiation exposure and public health before and after the operation of Sanmen nuclear power plant
Authors: Ren Hong , Yu Shunfei , Wang Ziyou , Zheng Taotao , Zou Hua , Lou Xiaoming , Wang Peng , Zhou Lei , Zhang Dongxia , Zhang Meibian , Guo Jiadi , Lai Zhongjun , Zhao Yaoxian , Xuan Zhiqiang , Cao Yiyao
Published: February 2023

Introduction

Sanmen nuclear power plant (SNPP) operates the first advanced passive (AP1000) nuclear power unit in China.

Methods

To assess the radiological impacts of SNPP operation on the surrounding environment and the public health, annual effective dose (AED) and excess risk (ER) were estimated based on continuous radioactivity monitoring in drinking water and ambient dose before and after its operation during 2014–2021. In addition, the residents' cancer incidence was further analyzed through authorized health data collection.

Results

The results showed that the gross α and gross β radioactivity in all types of drinking water were ranged from 0.008 to 0.017 Bq/L and 0.032 to 0.112 Bq/L, respectively. The cumulative ambient dose in Sanmen county ranged from 0.254 to 0.460 mSv/y, with an average of 0.354 ± 0.075 mSv/y. There is no statistical difference in drinking water radioactivity and ambient dose before and after the operation of SNPP according to Mann–Whitney U test. The Mann-Kendall test also indicates there is neither increasing nor decreasing trend during the period from 2014 to 2021. The age-dependent annual effective doses due to the ingestion of drinking water or exposure to the outdoor ambient environment are lower than the recommended threshold of 0.1 mSv/y. The incidence of cancer (include leukemia and thyroid cancer) in the population around SNPP is slightly higher than that in other areas, while it is still in a stable state characterized by annual percentage changes.

Discussion

The current comprehensive results show that the operation of SNPP has so far no evident radiological impact on the surrounding environment and public health, but continued monitoring is still needed in the future.
Qluster: An easy-to-implement generic workflow for robust clustering of health data
Authors: Esnault Cyril , Rollot Melissa , Guilmin Pauline , Zucker Jean-Daniel
Published: February 2023

The exploration of heath data by clustering algorithms allows to better describe the populations of interest by seeking the sub-profiles that compose it. This therefore reinforces medical knowledge, whether it is about a disease or a targeted population in real life. Nevertheless, contrary to the so-called conventional biostatistical methods where numerous guidelines exist, the standardization of data science approaches in clinical research remains a little discussed subject. This results in a significant variability in the execution of data science projects, whether in terms of algorithms used, reliability and credibility of the designed approach. Taking the path of parsimonious and judicious choice of both algorithms and implementations at each stage, this article proposes Qluster, a practical workflow for performing clustering tasks. Indeed, this workflow makes a compromise between (1) genericity of applications (e.g. usable on small or big data, on continuous, categorical or mixed variables, on database of high-dimensionality or not), (2) ease of implementation (need for few packages, few algorithms, few parameters, ...), and (3) robustness (e.g. use of proven algorithms and robust packages, evaluation of the stability of clusters, management of noise and multicollinearity). This workflow can be easily automated and/or routinely applied on a wide range of clustering projects. It can be useful both for data scientists with little experience in the field to make data clustering easier and more robust, and for more experienced data scientists who are looking for a straightforward and reliable solution to routinely perform preliminary data mining. A synthesis of the literature on data clustering as well as the scientific rationale supporting the proposed workflow is also provided. Finally, a detailed application of the workflow on a concrete use case is provided, along with a practical discussion for data scientists. An implementation on the Dataiku platform is available upon request to the authors.
Analyzing fast and slow: Combining traditional and rapid qualitative analysis to meet multiple objectives of a complex transnational study
Authors: Suchman Lauren , Omoluabi Elizabeth , Kramer Julia , Vallin Janelli , Sedlander Erica , Gitome Serah , Wekesa Pauline , Kwena Zachary , Granovsky Rachel , Kayego Agnes , Kaudha Betty , Atuyambe Lynn , Amongin Dinah , Alitubeera Phoebe , Tijani Aminat , Okoli Chioma , Jegede Ayobambo , Kamanga Martha , Nyando Mandayachepa , Ndunyu Louisa , Holt Kelsey ,   The ICAN Research Consortium
Published: February 2023

Much of the methodological literature on rapid qualitative analysis describes processes used by a relatively small number of researchers focusing on one study site and using rapid analysis to replace a traditional analytical approach. In this paper, we describe the experiences of a transnational research consortium integrating both rapid and traditional qualitative analysis approaches to develop social theory while also informing program design. Research was conducted by the Innovations for Choice and Autonomy (ICAN) consortium, which seeks to understand how self-injection of the contraceptive subcutaneous depot medroxyprogesterone acetate (DMPA-SC) can be implemented in a way that best meets women's needs, as defined by women themselves. Consortium members are based in Kenya, Uganda, Malawi, Nigeria, and the United States. Data for the ICAN study was collected in all four countries in sub-Saharan Africa. In order to both illuminate social phenomena across study sites and inform the program design component of the study, researchers developed tools meant to gather both in-depth information about women's contraceptive decision-making and data targeted specifically to program design during the formative qualitative phase of the study. Using these two bodies of data, researchers then simultaneously conducted both a traditional qualitative and rapid analysis to meet multiple study objectives. To complete the traditional analysis, researchers coded interview transcripts and kept analytical memos, while also drawing on data collected by tools developed for the rapid analysis. Rapid analysis consisted of simultaneously collecting data and reviewing notes developed specifically for this analysis. We conclude that integrating traditional and rapid qualitative analysis enabled us to meet the needs of a complex transnational study with the added benefit of grounding our program design work in more robust primary data than normally is available for studies using a human-centered design approach to intervention development. However, the realities of conducting a multi-faceted study across multiple countries and contexts made truly “rapid” analysis challenging.
Comparative study of three different fixation techniques for the treatment of Neer type IIb distal clavicle fractures: A retrospective cohort study
Authors: Liu Zhi-Qing , Zhang Ming-Shi , Zhou Zi-Fei , Zhang Lei , Zheng Long-Po
Published: February 2023

Background

Recently, a locking plate (LP) combined with a suture button was applied for distal clavicle Neer type IIb fractures. However, to our knowledge, there is limited information on clinical outcomes surrounding locking plates combined with a suture button in the treatment of Neer type IIb distal clavicle fractures. The aim of this study was to compare the outcomes among three different fixation techniques for the treatment of Neer type IIb distal clavicle fractures.

Methods

We performed a retrospective cohort study of 53 patients with Neer type IIb distal clavicle fractures who were treated with a hook plate (HP group, 16 patients), a locking plate alone (LP group, 18 patients), or a locking plate with a suture button (LPSB group, 19 patients) in our hospital between March 2014 and August 2019. The clinical and radiological outcomes were evaluated, including union time, postoperative complications, and function of the shoulder joint.

Results

The follow-up period was at least 2 years for all patients. All patients in the LPSB group achieved bone healing at the final follow-up. No significant differences were observed, including age, sex, side, time to surgery, duration of surgery, and mean follow-up period among the three groups (p > 0.05). The union time was shorter in the LPSB group than in the other two groups (p < 0.05). Postoperative complications were lower in the LPSB group than in the other two groups (p < 0.05). The visual analog scale score and Constant–Murley score in the LPSB group were better than those in the other groups at 3 and 6 months postoperatively (p < 0.05).

Conclusion

Compared with HP and LP alone, LPSB yields better clinical outcomes and lower complication rates in the treatment of Neer type IIb distal clavicle fractures.
Case report: Disseminated intravascular coagulation in a dog following treatment with melarsomine for Dirofilaria immitis
Authors: Philp Helen S. , Farrell Kate S. , Li Ronald H. L.
Published: February 2023

Disseminated intravascular coagulation following melarsomine therapy forDirofilaria immitis (D. immitis)is reported in a 9-year-old female intact pit bull-type dog. The dog had been diagnosed withD. immitis(antigen and microfilaria positive) and treated with imidacloprid, moxidectin, doxycycline and 3 doses of melarsomine over a 92-day period. Seven days after the third melarsomine injection, the patient was presented to her family veterinarian due to right pelvic limb swelling. Prothrombin and activated partial thromboplastin times were prolonged beyond the detectable range. Treatment included vitamin K1 and fresh frozen plasma (FFP) prior to referral to the authors' institution. At this time the patient remained coagulopathic. Further investigations included thoracic radiographs, abdominal ultrasound and an echocardiogram. The patient was administered multiple units of packed red blood cells and FFP, sildenafil, dexamethasone SP, aminocaproic acid and vitamin K1. Repeat CBC approximately 20 h after admission showed persistent anemia and thrombocytopenia. Despite ongoing administration of FFP, a repeat coagulation panel showed worsening of the coagulopathy with prothrombin time of 84.2s [reference interval (RI) 7.0–9.3s], activated partial thromboplastin time >140s (RI 10.4–12.9s) and fibrinogen <50 mg/dL (RI 109–311 mg/dL). Following discussion with the owners, the patient was euthanized. Necropsy was performed and confirmed heartworm infection with severe pulmonary arterial thrombosis, vascular remodeling, and intraluminal degenerate nematodes. Multifocal subcutaneous and organ hemorrhage was apparent. Although coagulopathy has been described in caval syndrome associated with heartworm disease and is listed as a potential side effect of melarsomine administration, this is the first report of documented disseminated intravascular coagulation following melarsomine treatment forD. immitis. Potential mechanisms for the coagulopathy are discussed and the case report highlights a rare, but serious complication of adulticide therapy.
Comparison of Aerodynamic Loss of a Gas Turbine Vane with Various Trailing Edge Cooling Schemes
Authors: Kim Gi-Mun , Jeong Jin-Young , Kang Young-Jun , Kwak Jae-Su
Published: February 2023

In this study, a comparison of aerodynamic loss of gas turbine vane with various trailing edge configurations was experimentally performed. For the trailing edge, three cooling schemes (the cutback slot, the central injection slot, and the pressure side hole) and three levels of trailing edge diameter (7.5, 10.0, and 12.5% of the throat width, respectively) were considered. The total pressure loss was measured in a five-vane linear cascade at the low-speed mainstream condition (20 m/s) using a Kiel probe and a two-axis traversing device. The measurement region was constrained to the near mid-span region, and the measurement step size was 1 mm. The results showed that the distribution of the total pressure loss was strongly affected by cooling schemes. The vane with the pressure side hole showed a similar distribution to that of the baseline in which a cooling scheme was not applied. It was also shown that the total pressure loss increased as the trailing edge diameter increased regardless of the cooling schemes. Except for the cutback slot cases, there was an inflection point at which the tendency of the area-averaged total pressure loss to the blowing ratio was changed. Through the present study, correlation equations for each cooling scheme were derived against the trailing edge diameter and the blowing ratio.
Large-Eddy Simulations of Unsteady Reaction Flow Characteristics Using Four Geometrical Combustor Models
Authors: Meng Nan , Li Feng
Published: February 2023

Combustion instability constitutes the primary loss source of combustion chambers, gas turbines, and aero engines, and it affects combustion performance or results in a sudden local oscillation. Therefore, this study investigated the factors affecting flame fluctuation on unsteady combustion flow fields through large-eddy simulations. The effects of primary and secondary holes in a triple swirler staged combustor on flame propagation and pressure fluctuation in a combustion field were studied. Moreover, the energy oscillations and dominant frequencies in the combustion field were obtained using the power spectral density technique. The results revealed a variation in the vortex structure and Kelvin–Helmholtz instability in the combustion field, along with a variation in the pressure pulsation during flame propagation under the influence of the primary and secondary hole structures. Additionally, the spatial distributions of pressure oscillation and heat release rate amplitude were obtained, revealing that the foregoing increased owing to the primary and secondary holes in the combustion field, reaching a peak in the shear layer and vortex structure regions.