bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Reputasi, Kualitas Informasi, dan e-WOM terhadap Minat Beli pada Situs Jual Beli Online Tokopedia yang Dimediasi oleh Kepercayaan Pelanggan
Authors: Aisyah Dian , Engriani Yunita
Published: September 2020

1) the influence of trust on buying interest in buying and selling sites a positive influence, (2) the influence of reputation on trust positive influence, (3) the influence of information quality on trust positive influence, (4) perception of e-WOM on trust positive influence, (5) the influence of reputation, quality of information, e-WOM influences buying interest through the belief of a positive influence, this type of research is causative research. This research was conducted in the city of Padang, West Sumatra. The population in this study are all Tokopedia site buying and selling sites but have never made a purchase. The sample used as many as 200 people using purposive sampling techniques. The type of data in this study is primary data. Data were collected through a questionnaire and analyzed using the SmartPLS version 3.0 program. (1) The tendency of trust has a positive and significant effect on buying interest, (2) The tendency of reputation has a positive and significant effect on trust, (3) the quality of information has a positive and significant effect on trust in a positive influence, (4) e-WOM uses a positive and significant effect on trust positive influence, (5) positive influence is positive and significant effect on the desire to buy, Keywords: Purchase Interest, Trust, Reputation, Information Quality, e-WOM
The Influence of Islamic Attributes of Destination towards Destination Loyalty with Tourist Satisfaction as an Intervening Variable
Authors: Antoni Melika Naifah , Dwita Vidyarini
Published: September 2020

The purpose of this research are to analyze : (1) the influences of Islamic attributes of Destination on Destination Loyalty, (2) the influences of Islamic attributes of destination on tourist satisfaction, (3) the influences of tourist satisfaction on destination loyalty.The type of this research is causative research. The population on this research is Muslim traveler that already visited Kabupaten Pesisir Selatan. The total sample of this research was 281 people by using online questionnaire. The result of research show that (1) Islamic attributes of destination has significant influences on destination loyalty, (2) Islamic attributes of destination has significant influences on tourist satisfaction (3) Tourist satisfaction has significant influence on destination loyalty.For the future research it is better to explore more about variable that can influence destination loyalty. Keywords: Islamic Attributes of Destination, Tourist satisfaction, and Destination Loyalty
Pengenalan Physical Fitness di Luar Jam Sekolah Sebagai Upaya Penurunan Kasus Obesitas (Dampak Corona “Tetap di rumah”)
Authors: S Afrizal , Marheni Eddy , Ridwan M , Soniawan Vega , Purnomoi Eko
Published: September 2020

Sekolah merupakan bangunan atau lembaga untuk belajar dan mengajar serta tempat menerima dan memberi pelajaran. Proses pembelajaran di sekolah memiliki tujuan dan target capaian yang tersusun dalam sebuah kurikulum. Salah satunya adalah peningkatan kesehatan dalam pembelajaran pendidikan jasmani, olaharaga dan kesehatan (PJOK). Salah satu kesehatan yang masih menjadi tujuan pembelajaran PJOK ini adalah obesitas. Sumatera Barat berada pada kelompok dengan obesitas tinggi. Oleh karena itu dengan physical fitness di luar pembelajaran, nantinya dapat menurunkan obesistas siswa dan tentunya dapat diterapkan oleh semua guru PJOK di SMA. Hasil menunjukkan bahwa, Physical Fitness belum banyak dilaksanakan di Indonesia, khususnya Sumatera Barat. Pendidikan yang dilakukan hanya sebatas jam belajar yang ada disekolah, belum masuk pada kegiatan siswa diluar sekolah. Oleh karena itu, guru diajarkan membua tprogram diluar sekolah dengan memperhatikan porsi dan waktunya. Proses pengabdian berjalan dengan sangat baik, para guru juga sangat antusias mengikuti acara.
Et Médecine Légale: Preuve De Viol Par Visum Et Repertum
Authors: Budiono Arief , Sari Rika Maya , Widaningrum Ida , Isnandar Aries
Published: September 2020

Le viol fait partie d'un crime sexuel dont la preuve est assez compliquée si la victime ne se présente pas immédiatement ou si les responsables de l'application des lois ne le traitent pas rapidement. Visum et repertum est un rapport d'aspect médical rédigé par un médecin à la demande écrite des autorités répressives aux fins d'enquête et d'examen des affaires plus tard devant les tribunaux, de sorte que visum et repertum ne peut être soumis que par les forces de l'ordre ou des autorités telles que la police, les procureurs, ou un juge de la cour à un médecin spécial qui s'occupe du terrain, le procureur et le juge demandent qu'un autopsie soit faite par la police.Cette étude utilise une méthode doctrinale normative, le résultat de la recherche est que le processus de prouver le viol en tant que crime sexuel présente des différences et des difficultés qui sont différentes des autres affaires pénales générales, car des preuves sont nécessaires sous la forme de visum et repertum qui révéleront les auteurs et le moment de l'incident pour faciliter la recherche et déterminer les auteurs de ces actes, le problème de visum et repertum est la preuve dépend des croyances des juges, comme d'autres preuves la position de visum et repertum est la même que la preuve documentaire en termes de force, mais l'obstacle est la culture en Indonésie qui fait que les victimes de viol ne signalent pas ou ne signalent pas mais en la période écoulée, ce qui rend difficile la post mortem elle-même.
Conhecimento de enfermeiros sobre reações transfusionais: revisão integrativa
Authors: Bastos da Silva Santos Amanda Azevedo , Costa Teixeira Josilene da , Silva Pereira Luana do Carmo da , Araújo Silva Amanda Lorena de
Published: September 2020

Descrever por meio de uma revisão integrativa da literatura o conhecimento dos enfermeiros sobre reações transfusionais. Trata-se de uma pesquisa descritiva, qualitativa cujo levantamento bibliográfico ocorreu em outubro de 2019. As bases de dados utilizadas foram PubMed, SciELO, BDEnf e LILACS. Foram identificadas 459 publicações, das quais 56 disponíveis no formato completo, excluíram-se produções duplicadas, que não atendem aos critérios de inclusão e artigos de outras bases de dados que não as supracitadas, restando 08 artigos, como amostra final. Os dados foram organizados em um quadro, com a identificação do artigo com base em sua referência e a sumarização de seus resultados. Conclui-se que há fragilidade no conhecimento dos profissionais de enfermagem e falta de estudos voltados para a temática, e com isso, incorrendo em negligência e, por conseguinte, riscos à saúde do paciente, prejudicando a qualidade da assistência à saúde.
Aspectos terapêuticos e nutricionais de neonatos submetidos a correção de atresia esofágica
Authors: Pinheiro Oliveira Karina Cristina , Cravo Salustiano Maria Victória , Lopes Vaz Gilmara , Tavares Parente Andressa , Parente Angeline do Nascimento , Barbosa de Carvalho Gelma Helena , Santos Arêas Claudia Giselle
Published: September 2020

Descrever as variáveis neonatais, condições clínicas e nutricionais de recém-nascidos portadores de Atresia Esofágica submetidos a correção cirúrgica. Estudo documental, retrospectivo e quantitativo em 50 prontuários de neonatos portadores de atresia de esôfago, internados em um hospital de referência. Na amostra: 96% das genitoras realizaram o pré-natal, com 64% nascidos de parto cesáreo, sendo 62% do sexo feminino e 60% dos neonatos nasceram com peso normal. Sobre a classificação da Atresia Esofágica, 84% tipo C. A média da amostra foi de 10 dias de vida a submissão da cirurgia de correção e 20 dias de vida para introdução da dieta. A idade média no alcance da dieta plena foi de 30 dias, sendo em torno do 21º dia de pós-operatório. A amamentação foi informada em 44% da amostra. Predominou consonâncias entre as variáreis do estudo comparadas com publicações nacionais e internacionais sobre o tema.
Mortalidade infantil: perfil epidemiológico da região do médio Vale do Itajaí
Authors: Steffens da Silva Simone Isabel , França de Moraes Ana Carolina , Lisieski Nadia
Published: September 2020

A mortalidade infantil é um indicador que estima a proporção de óbitos em crianças com menos de um ano, ocorridos em determinado período e lugar. O artigo tem como objetivo identificar o perfil epidemiológico da mortalidade infantil da Região do Médio Vale do Itajaí (RMVI) no período entre 2014 e julho de 2019. O estudo trata-se de uma pesquisa quantitativa de caráter descritivo exploratório, no qual foram pesquisados dados de acesso público, disponíveis no Sistema de Informações sobre Mortalidade (SIM) e no Sistema de Informações sobre Nascidos Vivos (SINASC). Os resultados foram aplicados em tabelas e gráficos e analisados com embasamento bibliográfico. Conhecer o perfil epidemiológico permite aos profissionais de saúde e gestores identificar a população de maior vulnerabilidade e implementar medidas de prevenção e proteção à saúde, com vistas à redução da mortalidade infantil.
WACANA POLITIK PENDIDIKAN DALAM PERKEMBANGAN DEMOKRASI DI INDONESIA
Authors: Ramadhani Pulungan Husniah
Published: September 2020

The political education discourse in the development of democracy in Indonesia has influenced the progress of the education system. This is inseparable from the long process of history with various educational political products that have been produced that contribute to the progress of the nation's education. The political education discourse in Indonesia is still proceeding in producing an ideal democratic system. In political discourse, education is still used as one of the main issues in raising public confidence in the leaders, starting from colonialism, a new era, reformation to the present. Thus, the politics of education is one important thing in realizing a positive symbol of democracy in Indonesia.
KENABIAN DINAMIS ATAU FINAL
Authors: Hasibuan Armyn
Published: September 2020

This paper is a literature review that contains dynamic or final prophethood.  Prophethood is a very interesting thing to talk about. Through this paper, it is expected that readers will be easier to understand about the concept of prophethood is dynamic or final. In this paper it has been found through the evidence of the argument that it is clear that prophethood was final through the explanation of the Koran. Then, this paper does not need a continuation to be explored by future researchers.
PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE JIGSAW TERHADAP HASIL BELAJAR POKOK BAHASAN MENELADANI KETAATAN MALAIKAT
Authors: Harahap Meli Sartika , Rangkuti Ahmad Nizar , Dalimunthe Latifa Annum
Published: September 2020

Penelitian ini bertujuan untuk mengetahui pengaruh yang signifikan model pembelajaran kooperatif tipe Jigsaw terhadap hasil belajar pokok bahasan meneladani ketaatan malaikat-malaikat  Allah Swt kelas VII di SMP Negeri 1 Angkola Timur. Penelitian ini menggunakan pendekatan kuantitatif dengan metode eksperimen. Sampel penelitian ini adalah siswa kelas VII1 sebagai kelas eksperimen dan kelas VII2 sebagai kelas kontrol. Instrumen penelitian ini adalah tes hasil belajar yang valid dan reliable. Hasil penelitian menunjukkan bahwa terdapat pengaruh yang signifikan model pembelajaran kooperatif tipe Jigsaw terhadap hasil belajar siswa. Hal ini ditunjukkan dari hasil pengujian hipotesis dengan menggunakan uji-t menghasilkan nilai thitungttabel yaitu 3,80 1,98 dengan taraf signifikansi 0,05.
KESULITAN MAHASISWA DALAM PEMBUKTIAN MATEMATIS POKOK BAHASAN SIFAT URUTAN PADA BILANGAN REAL
Authors: Siregar Nur Fauziah
Published: September 2020

Penelitian ini bertujuan untuk mendeskripsikan kesulitan-kesulitan yang dialami mahasiswa dalam menyelesaikan soal matematika pada mata kuliah Analisis Real-1 khususnya dalam pokok bahasan sifat dan urutan pada bilangan real. Penelitian ini merupakan penelitian deskriptif dengan objek penelitiannya adalah mahasiswa semester IV program studi tadris/pendidikan matematika di IAIN Padangsidimpuan yang berjumlah 34 orang  dengan tingkat kemampuan heterogen. Instrumen pengumpulan data menggunakan tes essay. Analisis data dilakukan dengan mereduksi data kemudian menyajikan data dalam bentuk paragraf dan gambar, selanjutnya mengambil kesimpulan. Hasil penelitian ini menunjukkan bahwa kesulitan umum yang dialami mahasiswa pada penelitian ini terjadi pada (1) kesulitan memahami konsep pernyataan atau simbol matematika, dan (2) menyusun bukti kebenaran secaramatematis
HUBUNGAN ANTARA LEVELS OF INQUIRI (LOI) DAN KETERAMPILAN PROSES SAINS DALAM PEMBELAJARAN IPA
Authors: Syafrilianto Syafrilianto Syafrilianto
Published: September 2020

Proses pembelajaran IPA diidentikkan seperti cara para ilmuwan memperoleh teori atau konsep yang dikenal dengan metode ilmiah. Salah satu pendekatan pembelajaran yang sesuai dengan pembelajaran IPA adalah Levels of Inquiry. Artikel ini merupakan studi analisis literatur yang mendeskripsikan tentang karakteristik Levels of inquiry dalam pembelajaran IPA serta hubungannya dengan keterampilan proses sains. Berdasarkan analisis literatur yang dilakukan, diperoleh hubungan antara pendekatan levels of inquiry dan keterampilan proses sains dalam pembelajaran IPA. Hal ini disebabkan karena pada tiap tahapan levels of inquiry melatihkan keterampilan proses sains yang berbeda sesuai dengan level atau tingkatannya, mulai dari level terendah yaitu discovery learning yang melatihkan rudimentary skills hingga level tertinggi hypothetical inquiry yang melatihkan advanced skills. Dengan demikian, Levels of Inquiry memiliki hubungan dengan keterampilan proses sains sehingga dapat dijadikan sebagai salah satu alternatif pendekatan pembelajaran IPA untuk melatihkan dan meningkatkan keterampilan proses sains mulai jenjang pendidikan dasar,menengah hingga jenjang pendidikan tinggi.
PENINGKATAN HASIL BELAJAR SISWA DENGAN MENGGUNAKAN MEDIA GAMBAR BERBASIS KOLASE PADA PEMBELAJARAN TEMATIK DI MADRASAH IBTIDAIYAH PADANGSIDIMPUAN
Authors: Lubis Maulana Arafat
Published: September 2020

The problem that is found in this research is low learning outcomes of IV grade student in MI Padangsidimpuan Angkola Julu in thematic learning. The problem is caused learning system given by teacher still not fun, so it does not make student desire in following the learning. This research is conducted to improve learning outcome of IV grade student in MI Padangsidimpuan Angkola Julu in following thematic learning in the theme the beauty of diversity in my country, material magnetic force and gravitational force using collage picture media. This is classroom action research that is consisted of two cycles and every cycle consist of four steps, they are (1) planning, (2) implementation, (3) observation, (4) reflection. The technique of data collection uses observation, test, and interview. Data analysis techniques are conducted qualitatively and quantitatively using questionnaire data analysis in the form of percentages (%) to get the success of image media implementation toward student’s learning outcome. Based on the results of teacher’s observations using collage picture media that it obtains 85,5% in the first cycle and 92,5% in the second cycle. The data shows an increase in teacher’s activity in improving student’s learning outcomes. Based on observation result, there is increase in student’s learning outcome where cycle I gets 60% and cycle II gets 84%. The average of student’s learning outcome gets increase percentage of 24%. Research result can be concluded that the use of collage picture media can improve student’s learning outcome on thematic learning.
Introducing a local legal vocabulary in a Latin context
Authors: Landqvist Hans , Rogström Lena
Published: September 2020

In this article, the use and consolidation of legal vocabulary is investigated in two Swedish legal handbooks from the 17th century written by Clas Rålamb and Claudius Kloot respectively. Both handbooks were written in Swedish but include elements in Latin. Sections of the handbooks that deal with civil cases were analyzed from a lexicological starting point. The 106 legal concepts (LC) and 169 lexical units (LU) identified are sorted into four central semantic areas of the legal process: ACTIONS, ARENAS, PARTICIPANTS and TOOLS. Kloot uses more LCs and more LUs than Rålamb who, on the other hand, shows greater lexical differentiation than Kloot. Rålamb is also shown to use a greater number of Latin LUs than Kloot. The area of TOOLS has the closest connection to Latin. Both authors make use of Latin LUs that are still part of Swedish legal vocabulary. Kloot has a stronger tendency to use Swedish LUs when possible, while Rålamb more freely combines Swedish and Latin LUs. Rålamb’s and Kloot’s use of Latin and Swedish LUs is discussed as well as their policies regarding the use of Latin and Swedish. Finally, the lexication of Latin and Swedish LUs in the legal domain in Swedish is discussed.
Predicting Land use and land cover spatiotemporal changes utilizing CA-Markov model in Duhok district between 1999 and 2033
Authors: Abdulrahman Ashti I. , Ameen Shamal A.
Published: September 2020

The process of spatiotemporal changes in land use land cover (LULC) and predicting their future changes are highly important for LULC managers. one of the most important challenges in LULC studies is considered to be the creation of simulation of future change in LULC that involve spatial modeling. the purpose of this study is to use GIS and remote sensing to classify LULC classes in Duhok district between 1999 and 2018, and their results calculated using an integrated cellular automaton and ca-markov chain model to simulate LULC changes in 2033. in this study, satellite images from landsat7 ETM and landsat8 oli used for Duhok district which is located in the northern part of Iraq obtained from united states geological survey (USGS) for the periods (1999 and 2018) analyzed using remote sensing and GIS techniques in addition to the ground control points, for each class 60 ground points have taken. to simulate future LULC changes for 2033, integrated approaches of cellular automata and ca-markov models utilized in Idrisi selva software. the outcomes demonstrate that Duhok district has experienced a total of 184.91km changes during the period (table 4). the prediction also indicates that the changes will equal to 235.4 km by 2033 (table 8). soil and grass constitute the majority of changes among LULC classes and are increasing continuously. the achieved kappa values for the model accuracy assessment higher than 0.93 and 0.85 for 1999 and 2018 respectively showed the model’s capability to forecast future LULC changes in Duhok district. thus, analyzing trends of LULC changes from past to now and predict future applying ca-markov model can play an important role in land use planning, policy making, and managing randomly utilized LULC classes in the proposed study area.
Türkiye’deki Mevduat Bankalarının Performansı
Authors: OVA Alper
Published: September 2020

Bu çalışma Türkiye’deki mevduat bankalarının 2011-2018 yılları arasındaki performasını Stokastik Sınır analiziyle incelemektedir. Ayrıca çalışma 4 girdi ve etkinsizliğe etki edebilecek banka büyüklüğü, sahiplik (kamu ya da özel; yerli ya da yabancı), Türkiye’de kurulmuş olma, zaman, TL aktif / Toplam aktif, Likit aktif / Toplam aktif ve Toplam ücret / Çalışan sayısı gibi sekiz değişkeni incelemektedir. Modelin popüler olması, verinin dengesiz bir veri seti olması ve etkinsizlik etkilerini verdiği için Battese ve Coelli (1995) model analizde kullanılmıştır. Sonuçlara göre büyük bankalar küçük bankalara göre daha iyi performans göstermektedir. Türkiye’de kurulmuş olmak mevduat bankalarının performansını artırıcı bir etki yapmaktadır. Çalışanlara daha fazla ücret ödemek banka performansının daha iyi olacağı anlamına gelmemektedir, kamu bankası ya da özel banka olmanın etkinsizlik üzerine önemli bir etki yaptığı görülmemektedir, yabancı banka olmak etkinsizliği azaltmakta ve zaman Türk banka endüstrisinin etkinsizliği üzerinde pozitif bir etki yapmaktadır.
PERCEPÇÕES E REAÇÕES DE PROFESSORES DIANTE DAS POLÍTICAS EDUCACIONAIS: UM ESTUDO COM PROFESSORES DE EDUCAÇÃO FÍSICA
Authors: Furtado Andre Osvaldo , Wittizorecki Elisandro Schultz , Tavares Natacha Da Silva
Published: September 2020

RESUMOEste estudo busca compreender como os professores de Educação Física atuantes na Rede Estadual de Ensino do Rio Grande do Sul percebem e reagem às políticas educacionais que lhes são demandadas pelos gestores estaduais nas ultimas três gestões do governo estadual do Rio Grande do Sul. Neste sentido foi realizada uma pesquisa qualitativa na perspectiva da etnografia. Como obtenção de informações foram realizadas: observações participantes do cotidiano dos professores de Educação Física, registrada nos diários de campo; entrevistas semiestruturadas com cinco professores de Educação Física e análise de documentos. Através da análise foi possível construir unidades de significado que agrupadas resultaram em três categorias analíticas: a indiferença, a resistência e as marcas. Compreendemos que o professorado de Educação Física participante deste estudo atua em dado momento da sua prática pedagógica com indiferença e resistências às políticas educacionais formuladas pelos gestores. É possível pensarmos que a resistência dos professores é potencializada quando eles são convidados a preterir elementos da sua história de vida que estão imbricados na sua prática pedagógica.Palavras-chave: Ensino Médio. Trabalho docente. Políticas Educacionais. Prática Pedagógica. ABSTRACTThis study aims to understand how Physical Education teachers from Rio Grande do Sul public state schools follow and react to educational policies demanded by the local and state authorities from the last three state government management of Rio Grande do Sul. In this context, a research focused on ethnography was conducted. To obtain information, there were performed observations in the daily routine of Physical Education teachers, recorded in the field journal; semi-structured interviews with five Physical Education teachers and data analyses. Because of the analyses, it was possible to build meaning units, which organized, result in three analytical categories: the indifference, the resistance, and the marks. The results suggest that the Physical Education teachers, who participated the study, act in their teaching practice indifferently and resistant to educational policies formulated by the state managers. It suggests that the resistance of the teachers is reinforced when they are led to ignore elements from their own life experience which are interwoven with their teaching practices.Keywords: High School. Teaching. Educational policies. Teaching practices.
TERRITÓRIOS EDUCATIVOS DE INTERVENÇÃO PRIORITÁRIA: UM INVENTÁRIO DO CONHECIMENTO DIVULGADO EM PERIÓDICOS
Authors: Fritsch Rosangela , Leite Carlinda
Published: September 2020

RESUMOOs Territórios Educativos de Intervenção Prioritária (TEIP) constituem, em Portugal, uma política educacional que tem como objetivo promover o sucesso escolar e a inclusão para populações marcadas por problemas econômicos e sociais. Diante disso, este artigo busca inventariar a produção de conhecimento acumulada acerca da temática, elucidando os efeitos e os condicionantes da política no que concerne à promoção da igualdade de oportunidades para todos os grupos sociais na perspectiva da justiça social e curricular. Para isso, procedeu-se a uma pesquisa bibliográfica em revistas indexadas no Portal de Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), realizando uma análise bibliométrica e interpretativa das publicações sobre os TEIP encontradas. A partir da pesquisa efetuada, foi possível constatar, na trajetória de mais de 20 anos dessa política, efeitos positivos no âmbito dos agrupamentos de escolas TEIP. Além disso, percebeu-se que os efeitos negativos e condicionantes são de natureza estrutural e reproduzem, em grande medida, uma visão desvalorizada dos alunos e do estigma TEIP. Para romper os círculos de privação e reprodução social que marcam as experiências educativas nas instituições TEIP, é necessária uma política não apenas compensatória, mas também transformadora das estruturas escolares e comunitárias.Palavras-chave: Política de educação. Territórios Educativos de Intervenção Prioritária. Inclusão social e escolar. ABSTRACTThe Education Territories of Priority Intervention (TEIP) constitute, in Portugal, an education policy which aims to promote school success and inclusion for populations marked by economic and social issues. Thus, this paper seeks to inventory the accumulated knowledge production about this theme, elucidating the effects and the determinants of this policy regarding the equality of opportunity promotion for all the social groups in the perspective of social and curricular justice. For this purpose, we proceeded to a bibliographical research in indexed journals available on the Periodical Portal of the Brazilian Federal Agency for Support and Evaluation of Graduate Education (CAPES), carrying out a bibliometric and interpretative analysis of publications about TEIP found on the Portal. Based on this research, we were able to verify, in the over 20-year trajectory of this policy, positive effects on the ambit of TEIP school clusters. Besides that, it was noticed that the negative effects and determinants are from structural nature and reproduce, to a great extent, a devalued view of students and TEIP stigma. In order to break the circles of social deprivation and reproduction that mark the educational experiences in TEIP institutions, a policy not only compensatory, but also transformative of school and community structures, is needed.Keywords: Education policy. Education Territories of Priority Intervention. Social and school inclusion.
СУТНІСТЬ ТА СТРУКТУРА ОРГАНІЗАЦІЙНОГО ЗАБЕЗПЕЧЕННЯ СТРАТЕГІЧНОГО УПРАВЛІННЯ КОРПОРАТИВНОЮ СОЦІАЛЬНОЮ ВІДПОВІДАЛЬНІСТЮ
Authors: Kamyshnykova Evelina
Published: September 2020

Статтю присвячено розробленню організаційного забезпечення стратегічного управління корпоративною соціальною відповідальністю з урахуванням рефлексивного підходу до управління відносинами зі стейкхолдерами. Розглянуто наявні теоретичні підходи до визначення сутності поняття «організаційне забезпечення» та запропоновано комплексний структурно-ресурсний підхід до характеристики цієї категорії. Досліджено варіанти формування організаційних структур щодо впровадження стратегічних соціально відповідальних рішень у практику діяльності підприємств. Запропоновано модель організаційно-управлінської структури для реалізації стратегічного управління корпоративною соціальною відповідальністю, яка передбачає введення на функціональному рівні нового підрозділу –
департаменту з корпоративної соціальної відповідальності у складі трьох відділів: проєктно-аналітичного, рефлексивного управління та комунікаційного.
Binding of Divalent Cations to Aqueous Acetate: Molecular Simulations Guided by Raman Spectroscopy
Authors: Mendes de Oliveira Denilson , Zukowski Samual R. , Palivec Vladimir , Hénin Jérôme , Martinez-Seara Hector , Ben-Amotz Dor , Jungwirth Pavel , Duboué-Dijon Elise
Published: September 2020

In spite of the biological importance of the binding of Zn2+, Ca2+, and Mg2+ to the carboxylate group, cation-acetate binding affinities and binding modes remain actively debated. Here, we report the first use of Raman multivariate curve resolution (Raman-MCR) vibrational spectroscopy to obtain self-consistent free and bound metal acetate spectra and one-to-one binding constants, without the need to invoke any a priori assumptions regarding the shapes of the corresponding vibrational bands. The experimental results, combined with classical molecular dynamics simulations with a force field effectively accounting for electronic polarization via charge scaling and ab initio simulations, indicate that the measured binding constants pertain to direct (as opposed to water separated) ion pairing. The resulting binding constants do not scale with cation size, as the binding constant to Zn2+ is significantly larger than that to either Mg2+ or Ca2+, although Zn2+ and Mg2+ have similar radii that are about 25% smaller than Ca2+. Remaining uncertainties in the metal acetate binding free energies are linked to fundamental ambiguities associated with identifying the range of structures pertaining to non-covalently bound species.
Themis: A Software to Assess Association Free Energies via Direct Estimative of Partition Functions
Authors: Colombari Felippe , Lozada-Blanco Asdrubal , Bernardino Kalil , Gomes Weverson , Farias de Moura André
Published: September 2020

We present the program Themis - a computer implementation of a standard statistical mechanics framework to compute free energies, average energies and entropic contributions for association processes of two atom-based structures. The partition functions are computed analytically using a discrete grid in the phase space, whose size and degree of coarseness can be controlled to allow efficient calculations and to achieve the desired level of accuracy. With this strategy, applications ranging from molecular recognition, chiral discrimination, surface adsorption and even the interactions involving molecules in electronic excited states can be handled.
High-Resolution Mining of SARS-CoV-2 Main Protease Conformational Space: Supercomputer-Driven Unsupervised Adaptive Sampling
Authors: Jaffrelot Inizan Theo , Célerse Frédéric , Adjoua Olivier , El Ahdab Dina , Jolly Luc-Henry , Liu Chengwen , Ren Pengyu , Montes Matthieu , Lagarde Nathalie , Lagardère Louis , Monmarché Pierre , Piquemal Jean-Philip
Published: September 2020

We provide a new unsupervised adaptive sampling strategy capable of producing microsecondtimescale molecular dynamics (MD) simulations using many-body polarizable force fields (PFF) on modern supercomputers. The global exploration problem is decomposed into a set of separate MD trajectories that can be restarted within an iterative/selective process to achieve sufficient phase-space sampling within large biosystems, while accurate statistical properties can be obtained through debiasing. With this pleasingly parallel setup, the Tinker-HP package can be powered by an arbitrary large number of GPUs (Graphics Processing Unit) cards available on pre-exascale supercomputers, reducing to days explorations that would have taken years. We applied the approach to the urgent problem of the modeling of the SARS–CoV–2 Main protease (Mpro) dimer. A 15.14 microsecond high-resolution all-atom simulation (AMOEBA PFF) of its apo state is provided and compared to other available long-timescale non-PFF data. Noticeable differences are found between clustering analysis of the simulations, the AMOEBA adaptive results exhibiting a richer conformational space. Overall, our high-resolution AMOEBA structural analysis captures key experimental observations concerning the stability of the oxyanion hole, a marker of activity through the stability of different stacking and salt bridge interactions. A dissymmetry is found between the enzyme protomers that exhibit different volumes. One of them appears fully inactive while the other is "activable", exhibiting some partial activity features. This activity evaluation can be further traced back to the large flexibility of the C terminal domain, fully captured by AMOEBA but not seen in X-rays due to insufficient electron densities related to the domain high mobility. The C–terminal region of the fully inactive protomer is shown to oscillate between several states, one of them interacting with the other protomer active site, therefore potentially modulating down its activity. Overall, these results reinforce the experimental hypothesis of a full inactivation of the apo state and clearly capture the asymmetric nature of protomers. Additional analysis show that the cavities volumes of the active and distal sites are found to be larger in the most active protomer with AMOEBA. To a larger extend, the PFF finds significantly larger cavities than those obtained with classical, non-polarizable simulations. The consequences on druggability are discussed as additional potential druggable cryptic pockets are found. All data produced within this research are fully accessible to the community for further analysis.
Dynamic Stereoselection of Peptide Helicates and Their Selective Labeling of DNA Replication Foci in Cells
Authors: Gómez-González Jacobo , Pérez Yolanda , Sciortino Giuseppe , Roldán-Martín Lorena , Martínez-Costas José , Maréchal Jean-Didier , Alfonso Ignacio , Vázquez López Miguel , Vázquez M. Eugenio
Published: September 2020

Peptide engineering has been extremely successful in creating new structures with defined properties and functions. Although generally overlooked in this context, coordination chemistry offers an additional set of interactions that opens unexplored design opportunities for developing complex molecular structures. With this in mind, we report the development of new artificial peptide ligands that fold into chiral and discrete supramolecular helicates in the presence of labile metal ions such as Fe(II) and Co(II). By selecting appropriate heterochiral β‑turn promoting sequences, we can encode the stereoselective folding of the peptide ligand, and define the physicochemical properties of their corresponding metal complexes. The study of these metallopeptides by CD and NMR spectroscopy, combined with computational methods allowed us to identify and determine the structure of two isochiral ΛΛ-helicates, folded as topological isomers. We also show that these new peptide helicates, dynamically selected in the presence of labile Co(II) ions, can be locked as kinetically-inert species by in situ oxidation to Co(III). Finally, in addition to the in vitro characterization of their selective binding to three-way DNA, cell microscopy experiments demonstrated that a rhodamine-labeled Fe(II) helicate was internalized and selectively stains DNA replication factories in functional cells.
Evaluating the Benefits of Kinetic Monte Carlo and Microkinetic Modeling for Catalyst Design Studies in the Presence of Lateral Interactions
Authors: Li Xiao , Grabow Lars
Published: September 2020

Popular computational catalyst design strategies rely on the identification of reactivity descriptors, which can be used along with Brønsted−Evans−Polanyi (BEP) and scaling relations as input to a microkinetic model (MKM) to make predictions for activity or selectivity trends. The main benefit of this approach is related to the inherent dimensionality reduction of the large material space to just a few catalyst descriptors. Conversely, it is well documented that a small set of descriptors is insufficient to capture the intricacies and complexities of a real catalytic system. The inclusion of coverage effects through lateral adsorbate-adsorbate interactions can narrow the gap between simplified descriptor predictions and real systems, but mean-field MKMs cannot properly account for local coverage effects. This shortcoming of the mean-field approximation can be rectified by switching to a lattice-based kinetic Monte Carlo (kMC) method using cluster expansion representation of adsorbate−adsorbate lateral interactions.

Using the prototypical CO oxidation reaction as an example, we critically evaluate the benefits of kMC over MKM in terms of trend prediction accuracy and computational cost. After confirming that in the absence of lateral interactions the kMC and MKM approaches yield identical trends and mechanistic information, we observed substantial differences between the two kinetic models when lateral interactions were introduced. The difference, however, is mainly manifested in the absolute rates, surface coverages and the optimal descriptor values, whereas relative activity trends remain largely intact. Moreover, the nature of the rate-determining step as identified using Campbell’s degree of rate control is also consistent between both approaches. Considering that the computational cost of MKM is ca. three orders of magnitude lower than for a kMC simulation, the MKM approach does provide the best balance between accuracy and efficiency when used in the context of computational catalyst screening.
Nucleotide Interaction with Chitosan Layer Deposited on Fumed Silica Surface: Practice and Theory towards Establishing the Mechanism at the Molecular Level
Authors: Budnyak Tetyana , Vlasova Nataliya , Golovkova Lyudmila P. , Markitan Olga , Baryshnikov Glib V. , Ågren Hans , Slabon Adam
Published: September 2020

The growing interest in gene therapy is coupled to the strong need for the development of safe and efficient gene transfection vectors. A composite based on chitosan and fumed silica has been found to be a prospective gene delivery carrier. This study presents an investigation of the nature of the bonds between a series of mono-, di- and triphosphate nucleotides with a chitosan layer deposited on a fumed silica surface. It was observed that the adsorption of most of the studied nucleotides is determined by the formation of one surface complex. Experimentally measured surface complex formation constants (logK) of the nucleotides were found to be in range 2.69–4.02 which is higher than that for the orthophosphate (2.39). Theoretically calculated nucleotide complexation energies for chitosan deposited on the surface range from 11.5 to 23.0 kcal·mol–1 in agreement with experimental data. The adsorption of nucleotides was interpreted using their calculated speciation in aqueous solution. Based on the structures of all optimized complexes determined from quantum-chemical PM6 calculations, electrostatic interactions between the surface-located NH3+ groups and –PO3H––/–PO32- fragments of the nucleotides was identified to play the decisive role in the adsorption mechanism. The saccharide fragment of monophosphates also plays an important role in the binding of the nucleotides to chitosan through the creation of hydrogen bonds; in the case of di- and triphosphates the role of the saccharide fragment decreases significantly.
Mass Spectrometry Imaging Using Dynamically Harmonized FT-ICR at Million Resolving Power: Rationalizing and Optimizing Sample Preparation and Instrumental Parameters
Authors: Tiquet Mathieu , La Rocca Raphaël , van Kruining Daan , Martinez-Martinez Pilar , Eppe Gauthier , De Pauw Edwin , Quinton Loïc , Far Johann
Published: September 2020

MALDI mass spectrometry imaging (MSI) is a powerful analytical method giving access to the 2D localizations of compounds in a thin section of a sample. To properly discern isobaric compounds in complex biological samples, dynamically harmonized ICR cell (ParaCell©) has been introduce to achieve extreme spectral resolution. However, high resolution MS images realized on a 9.4T FTICR High resolution instrument with recommended parameters suffered from an abnormal shifting of m/z ratios pixel to pixel. Resulting datasets show poor mass accuracy measurements and resolutions under estimations. By following the behavior of the Total Ion Current in function of the number of laser shots, the abnormal mass shifting phenomenon has been linked to the stability of the Total Ion Current (TIC) during images acquisitions. An optimization of laser parameters is proposed in order to limit the observed mass shift to retain machine specifications during MSI analyses. It is also shown that the method has been successfully employed to realize quality MS images with resolution above 1,000,000 in the lipid mass range across the whole image.
Antimicrobial Photodynamic Activity of Gallium-Substituted Haemoglobin on Silver Nanoparticles
Authors: Morales-de-Echegaray Ana V. , Lin Lu , Sivasubramaniam badhu , Yermembetova Aiganym , wang qi , Abutaleb Nader S. , Seleem Mohamed N. , Wei Alexander
Published: September 2020

We have developed a nanosized agent for targeted antimicrobial photodynamic therapy (aPDT), comprised of GaPpIX (a hemin analog with potent photosensitizer activity) encapsulated in haemoglobin (GaHb), mounted on 10-nm Ag nanoparticles (AgNPs). The average GaHb–AgNP contains 28 GaPpIX units stabilized by Hb αβ-dimer units. Eradication (>6-log reduction) of S. aureus and MRSA can be achieved by a 10-second exposure to 405-nm irradiation from a light-emitting diode (LED) array (140 mW/cm2), with GaHb–AgNP loadings as low as 5.6 μg/mL for S. aureus and 16.6 μg/mL for MRSA, corresponding to nanomolar levels of GaPpIX. This reduction in bacterial count is several orders of magnitude greater than that of GaHb or free GaPpIX on a per mole basis. The GaHb-AgNP platform is also effective against persister MRSA and intracellular MRSA, and can provide comparable levels of aPDT with a 15-minute irradiation by an inexpensive compact fluorescent lightbulb. Collateral phototoxicity to keratinocytes (HaCaT cells) is low at the GaHb–AgNP concentrations and fluences used for aPDT. GaHb adsorbed on 10-nm AgNPs are much more potent than those on 40-nm AgNPs or 10-nm AuNPs, indicating that both size and plasmon-resonant coupling are important factors for enhanced aPDT.
Regioselective Dehydration of Sugar Thioacetals under Mild Conditions
Authors: Szpara Rachel , Goyder Alexander , Porter Michael , Hailes Helen , Sheppard Tom
Published: September 2020

Pentose and hexose sugars are abundant constituents of waste biomass, making them sustainable, chiral building blocks for organic synthesis. The demand for chiral saturated heterocyclic rings from the pharmaceutical industry is increasing as they provide well-defined three-dimensional frameworks that show increased metabolic resistance. Through the formation of thioacetals, sugars may be manipulated in their straight-chain form and dehydrated selectively under basic conditions at C-2. This approach was applied to an array of sugars and extended to the production of useful chiral THFs via further selective dehydration reactions.
Analisis Faktor yang Mempengaruhi Kejadian Demam Berdarah Dengue di Wilayah Kerja Puskesmas Way Kandis Bandar Lampung Tahun 2020
Authors: Husna Ismalia , Putri Devita Febriani , Triwahyuni Tusy , Kencana Guntur Batara
Published: September 2020

World Health Organization (WHO) melaporkan bahwa terjadi peningkatan jumlah kasus DBD khususnya di negara tropis seperti Indonesia. Di Bandar Lampung terjadi instabilitas pada Incidence Rate (IR) dari tahun 2010-2015 dan Tanjung Senang merupakan wilayah dengan angka kasus tertinggi yaitu 138 kasus. Tujuan penelitian ini untuk mengetahui faktor yang mempengaruhi kejadian Demam Berdarah Dengue (DBD) di Wilayah Kerja Puskesmas Way Kandis Bandar Lampung. Penelitian ini menggunakan desain penelitian case control. Sampel pada penelitian ini sebanyak 100 sampel dari 50 kasus DBD dan 50 kontrol. Teknik pengambilan sampel pada penelitian ini yaitu total sampling pada kelompok kasus dan random sampling pada kelompok kontrol. Analisa data yang digunakan adalah chi-square test. Hasil analisis statistik menggunakan uji Chi-square menunjukan variabel yang berhubungan dengan kejadian DBD adalah pengetahuan (p-value=0,02; OR=0,40; 95% CI:0,35 – 1,72) dan jumlah kontainer (p-value=0,01; OR=3,02; 95% CI:1,26-7,20). Variabel yang tidak berhubungan antara lain pendidikan, pekerjaan, perilaku, ketersediaan tutup kontainer, keberadaan kawat kassa dan jarak antar rumah karena p value > 0,05. Simpulan dari penelitian ini adalah pengetahuan dan jumlah container merupakan faktor yang berpengaruh terhadap kejadian DBD di Kelurahan Way Kandis.
Faktor Kejadian Anemia pada Pasien Kanker yang Mendapat Radioterapi dan atau Kemoterapi
Authors: Hidayati Alpha Olivia , Arifah Siti
Published: September 2020

Base on research, radiotherapy can reduce cancer recurrence in 10 years from 35% to 19,3% in breast cancer. However, the therapy given affects the life quality of patients, one of which is anemia. Anemia causes a decrease in response and tolerance to treatment. This study aims to determine the factors associated with the incidence of anemia in cancer patients who receive radiotherapy and or chemotherapy. This study was an observational analytic study with a cross-sectional design. The method of sampling with consecutive sampling with a minimum sample size of 47. The result showed the age of aÂ p-valueÂ (0,321)>0,05, the number of fractions aÂ p-valueÂ (0,181)>0.05, the frequency of light that had been conducted aÂ p-valueÂ (0,160)>0,05, type of radiotherapy aÂ p-valueÂ (0,933)>0,05, setting radiotherapy aÂ p-valueÂ (0,769)>0,05, history of blood transfusion during chemotherapy aÂ p-valueÂ (0,411)>0,05 and nutrient intake (Protein aÂ p-valueÂ (0,337)>0.05, iron aÂ p-valueÂ (0,086)>0,05, zinc aÂ p-valueÂ (0,411)>0,05, folic acid aÂ p-valueÂ (0,963)>0,05, vitamin C aÂ p-valueÂ (0,240)>0,05). Meanwhile, the total radiation dose received by respondents during one period of radiotherapy showed that there was a relationship with the incidence of anemia with aÂ p-valueÂ (0,045)<0,05. As conclusions, that there was no significant relationship between age, type of cancer, number of fractions, frequency of light that had been conducted, type of radiotherapy, radiotherapy settings, history of blood transfusion during chemotherapy and nutrient intake, while the total radiation dose given to respondents showed a significant relationship with anemia incidence.
Pengaruh Pijat I Love You (ILU) terhadap Rehabilitasi Fungsi Pencernaan Anak Pascaoperasi Perut
Authors: Lestari Yuli , Nurwindasari Nova
Published: September 2020

Recovery normal digestive function in postoperative abdominal patients requires a process of stages in the recovery period, phenomena in postoperative ileus are commonly found ileus in postoperative patients. Ileus or digestive peristalsis failure due to postoperative mechanical and non-mechanical factors of the abdomen, generally there are also include symptoms of abdominal distension and peristalsis. Providing complementary nursing care with the I Love You (ILU) massage method can help postoperative digestive stomach rehabilitation quickly. This study aims to identify the effect of I Love You (ILU) massage on the rehabilitation of digestive function postoperative stomach in RSUD Hi. Dr. Abdul Moeloek Lampung Province. The study used a quasi-experimental design, with a pre-post test design approach. The total sample of 32 respondents selected using nonprobability sampling with consecutive sampling techniques. The results showed the mean intestinal noise before ILU massage was 4.19; the estimated 95% interval result is believed that the mean bowel noise before intervention is 2.05 to 6.33 times. The mean intestinal noise after ILU massage was 4.88; the estimated 95% interval result is believed that the average bowel noise after the intervention is 2.54 to 7.21 times. Statistical test results showed that there were significant differences between bowel sounds before and after I Love You (ILU) massage (p-value=0.016). Complimentary massage therapy I Love You (ILU) can be a choice of intervention that can help the recovery process of the digestive function of postoperative stomach patients.
Sanitasi Pemukiman pada Masyarakat dengan Riwayat Penyakit Berbasis Lingkungan
Authors: Ahyanti Mei
Published: September 2020

Environmental-based diseases (PBL) are a health problem and occur in almost all geographical regions in the world. Every year, environment-based diseases are always found and reported to spread evenly at every Puskesmas in Bandar Lampung City. Settlement sanitation is an important aspect directly related to health and society. "Waterborne Disease" disease is still high, proving that there are still sanitation problems in settlements. The study aims to determine the relationship of settlement sanitation with environmental-based diseases in the city of Bandar Lampung. The study used a cross-sectional design, the population is all households in Bandar Lampung City. The sample was 384 respondents, taken randomly using multistage sampling. The results found 14,3% of respondents had a physical component of an unhealthy house, 45,3% of respondents had an unhealthy sanitation facility, 40,1% of the occupants of the house behaved in an unhealthy manner. The test results statistically concluded that there was a significant relationship between settlement sanitation and the incidence of environmental-based diseases.