bluuebunny/crossref_metadata_2025 huggingface dataset:
A béta-blokkoló-választás szempontjai
Authors: Nádházi Zoltán
Published: November 2024

A béta-blokkoló-gyógyszercsalád első, a betegek kezelésében is eredményesen alkalmazható képviselőjét, a propranololt több mint 6 évtizeddel ezelőtt ismerhették meg a gyakorló orvosok. Az azóta eltelt évek alatt a gyógyszeripar számos, béta-receptor-blokkoló tulajdonsággal rendelkező vegyületet szintetizált. Ezeknek a készítményeknek a receptor-blokkoló képességük mellett további, a klinikai hatásukat érdemben befolyásoló tulajdonságaik is vannak. A terápiás eredményességet egy adott béta-blokkoló jól ismert jellemzői mellett az emberi szervezet gyógyszerre adott válaszreakciója is érdemben befolyásolja. A különböző, béta-receptor-blokkoló tulajdonsággal rendelkező hatóanyagoknak ugyanis a szervezeti adottságoktól függően eltérő lehet a farmakokinetikája, illetve a farmakodinamikája, és ezzel összefüggésben a terápiás hatékonysága. A mindennapi gyakorlatban erre, a mindent tekintetbe vevő gyógyszerválasztásra pedig nem vagyunk, egyelőre nem lehetünk felkészültek.
Fluorescence Microscopy Imaging of Light-Harvesting in Self-Assembled Nanofibers of Naphthalenediimides towards Perylenediimide Guests
Authors: Sethy Ramarani , Brosseau Arnaud , Nakashima Takuya , Kawai Tsuyoshi , Métivier Rémi
Published: November 2024

The self-assembly of a bichromophoric naphthalenediimide (NDI) into nanofibers showed efficient energy transfer (light-harvesting) to perylenediimide (PDI) molecules through host-guest interaction, which can be visualized by microscopy using samples deposited on glass surfaces. In combination with atomic force microscopy (AFM), spectral and polarization analyses, fluorescence imaging unveiled the inhomogeneity, packing defects, and relative spatial arrangement of PDI and NDI molecular units, which were found to affect the exciton mobility along the NDI nanofibers and the energy transfer efficiency from NDI to PDI guests. Fluorescence micro-spectroscopy shows that efficient energy transfer occurs from NDI nanofibers to isolated PDI molecules and their partial self-aggregates. The NDI nanofibers emit strong blue polarized emission, while the emission corresponding to PDI guest molecules is weakly polarized, indicating the local disruption of NDI chromophores-ordering upon PDI guest binding.
Enhanced Near-Infrared Photogenerated Carrier Transfer via Doublet-State Excitation in D-π-A Structures for Biosensing
Authors: Yang Hong , Huang Chaofeng , Li Wang , Wang Yongji , Wang Kaiyuan , Wang Zhuang , Wang Ying , Liu Songqin , Shen Yanfei , Zhang Yuanjian
Published: November 2024

The feedback mechanisms of living systems to external signals are vital for survival, particularly through the conversion of light into bioelectric signals by photosensitive molecules, that regulate biological behavior and physiological processes. Nonetheless, the application of materials that rely on near-infrared (NIR) responses for in vivo or opaque sample analysis has been limited. Here, we report the preparation of a C3N2-based doublet-state system for developing novel NIR-responsive materials. Photogenerated carriers are generated from doublet-state dangling bonds in C3N2 and transferred to the highly conductive graphitic materials via donor-π-acceptor conjugated structures, leading to nearly 700-fold enhancement in NIR photoelectric conversion. These materials were further applied for real-time detection of tetracycline in a single drop of whole blood, demonstrating better sensitivity in NIR photoelectrochemical biosensing, which paves the way for broader applications of in vivo biofeedback.
Increasing Atomic Electron Cloud Density Leads to Formation of Body Centered Cubic (BCC) Gold
Authors: Gu Hengfei , Ren Jie , Wu Songquan , Li Mingyuan , Zhang Lifeng , Liu Chengze , Yuan Fusen , Han Fuzhou , Zhang Yingdong , Ali Muhammad , Guo Wenbin , Li Geping
Published: November 2024

Most metallic elements possess one relatively close packed structure of body-centered cubic (BCC), face-centered cubic (FCC) and hexagonal close packed (HCP) structures under ambient conditions. Access to these structures as a function of temperature and pressure varies for different groups in the periodic table. Under low pressures, the copper group elements (copper (Cu), silver (Ag) and gold (Au)) only have a FCC solid structure regardless of temperatures. Recently, BCC Au was detected under extreme compressive pressures. The structural preference for a given metal element is still not understood. In this work, we surprisingly observed formation of BCC Au from amorphous Au as well as FCC Au in vacuum at room temperature within a Au nanoparticle with electron self-transfer enabled by our synthesized zirconium hydroxide nitrate tube support. We propose a theory behind this unexpected phase formation: the increase in atomic electron cloud densities of Au atoms resulting from the electron transfer contributes more free electrons over the Au nanoparticle except its interfacial part, enhancing metallic bonding strength to hold Au atoms closer to form a BCC structure that can store denser electron states within a Fermi sphere in first Brillouin zone as compared to FCC Au. It can also explain formation of BCC Au under compression. Our theory here can be a supplement to the metallic bonding theory and our strategy via building heterogenous structures can guide how to expand the structure world of metals and their alloys under ambient conditions for beneficial applications.
Quantification of arginine-rich cyclic cell-penetrating peptide-lipid conjugates using trifluoracetic acid-based UPLC-MS/MS analysis
Authors: Bay Cindy , Uhl Philipp , Meid Andreas D. , Burhenne Jürgen , Haefeli Walter E. , Sauter Max
Published: November 2024

Lipid-based drug delivery systems can be surface-modified by lipid conjugates of the substance in question. The most important modifications include arginine-rich cell-penetrating peptides (CPP). A toxicokinetic evaluation of these lipid conjugates is im-portant during preclinical and clinical development of drug delivery formulations. Due to their amphiphilic properties and high number of basic amino acid residues, lipid conjugates of CPP exhibit difficult characteristics in regard to their plasma bioanalysis with LC-MS/MS instruments. These especially include challenging chromatography with extensive carry-over and minimal extrac-tion recovery, and, due to large numbers of basic amino acids and the resulting immobility of protons, resistance against collision-induced dissociation. We developed a surrogate quantification of a CPP-lipid conjugate relying on elimination of the lipid part by phospholipase D digestion. Chromatographic separation was only feasible with trifluoro acetic acid (TFA)-based mobile phases. Ion suppression caused by TFA was reversed by post-column addition of aqueous ammonia. Efficient extraction of the surrogate peptide fragment was achieved by protein precipitation with TFA. This enabled the highly sensitive quantification of the CPP-lipid conjugate in plasma in the low picomolar range (lower limit of quantification of 0.1 ng/mL; 34 pM). The assay was validated ac-cording to the pertinent recommendations of the ICH M10 guideline on bioanalytical method validation and applied to the deter-mination of the intravenous pharmacokinetics of the CPP-lipid conjugate in Beagle dogs. The established strategy can be used as a general approach to the bioanalysis of amphiphilic lipid conjugates and especially the TFA-based UPLC-MS/MS analysis with post-column desolvation of TFA adducts by ammonia is a feasible approach for the highly sensitive quantification of arginine-rich peptides and other related substances with challenging chromatographic characteristics.
All-graphite microchannel microbial fuel cells with high-power generation and conversion efficiency
Authors: Liu Linlin , Varroy William , Bansept Marc-Antoine , Cao Changhong , Boudreau Denis , Greener Jesse
Published: November 2024

In this work, we present a new “all-graphite” concept in microfluidic fuel cells, applied to microbial fuel cells (MFCs). The all-graphite microfluidic MFCs were fabricated by milling channels directly into the electrodes. Two such electrode channels were affixed face-to-face with separation by an ion exchange membrane to form a complete MFC. Three such MFCs were fabricated with simple straight channels having different channel heights and activated with pure culture anaerobic Geobacter sulfurreducens electroactive biofilm. After the proof-of-principle and correlation between the channel height and electroactive biofilm thickness, we demonstrated improvements on power and current outputs using a fourth design, which featured a high surface area provided by pillars. A high acetate conversion efficiency of more than 80% and low internal resistance of 1.2 kΩ were achieved using the pillar MFC. Additionally, a high-power density of 4.7 W m-2 was obtained with a straight channel MFC.
Abstraction of Hydride from Alkanes and Dihydrogen by the Perfluorotrityl Cation
Authors: Leong Derek , Gogoi Achyut , Maity Tapas , Lee Chun-I , Bhuvanesh Nattamai , Gutierrez Osvaldo , Ozerov Oleg
Published: November 2024

Lewis acids play a central role in a large variety of chemical transformations. The reactivity of the strongest Lewis acids is typically studied in the context of affinity towards hard bases, such as fluoride or oxygenous species. Carbocations can be viewed as soft Lewis acids, possessing significant affinity for softer bases, such as hydride. This work presents the ambient-temperature isolation of salts of the perfluorotrityl cation ((C6F5)3C+ or F15Tr+) in combination with halogenated carborane anions. The F15Tr+ cation exhibits remarkable hydride affinity, illustrated by the observation of hydride abstraction from dihydrogen, and of the rapid abstraction of hydride from -CH2- groups in alkanes. Theoretical studies support the favorability of hydride abstraction from dihydrogen, and indicate that the hydride abstraction from alkanes proceeds via a concerted hydride transfer process that is sensitive to steric effects.
Advanced Fast Fourier Transform-based Distribution of Relaxation Times Analysis for Efficient and Flexible Time-Domain Electrochemical Impedance Characterization
Authors: Py Baptiste , Ciucci Francesco
Published: November 2024

Electrochemical impedance spectroscopy (EIS) is a powerful analytical technique for studying electrochemical systems, offering broad frequency range coverage and straightforward implementation. However, EIS measurements at low frequencies are limited by both lengthy acquisition times and the risk of disrupting steady-state conditions, which is a particular challenge for battery systems. While the distribution of relaxation times (DRT) method has emerged as an effective tool for interpreting EIS data and accelerating impedance acquisition, existing acquisition approaches are limited to pulse-based input signals and their linear combinations. Here, we present a novel fast Fourier transform-based DRT formulation that enables rapid EIS acquisition using arbitrary current signals. Our approach demonstrates improved DRT and impedance recovery while ensuring computational efficiency. This advancement in DRT analysis and time-based measurements opens new possibilities for fast and efficient EIS characterization.
Discovery of a Concerted Mechanism in Arylmalonate Decarboxylase Expands the Catalytic Scope for Cofactor-free C-C Bond Cleavage
Authors: van der Pol Elske , Schlatzer Thomas , Hoffka Gyula , di Geronimo Bruno , Eder Johannes , Schweiger Anna Katharina , Karava Marianna , Fischer Roland , Kracher Daniel , Gross Dominik , Kazlauskas Romas , Miyamoto Kenji , Kamerlin Shina Caroline Lynn , Breinbauer Rolf , Kourist Robert
Published: November 2024

The cofactor-free arylmalonate decarboxylase (AMDase) has been applied for the synthesis of a large number of α-aryl and α-alkenylcarboxylic acids with outstanding stereoselectivity. We observed that (S)-selective AMDase variant ICPLLG produces a single product enantiomer from 2-methyl-2-phenyl malonate with 99% ee (S), but both product enantiomers from 2-methyl-2-vinyl malonate with 66% ee (S). This prompted us to investigate its mechanism. In the decarboxylation of an isotope-labeled, pseudochiral substrate, we observed that the AMDase variant decarboxylates alkenyl malonates only with inversion of the configuration at the α-C atom. This differs from the decarboxylation of arylmethyl malonates, which proceeds with retention. Further mechanistic investigations with kinetic isotope measurements and QM/MM well-tempered metadynamics calculations suggest an enforced concerted mechanism for the decarboxylation of alkenyl malonic acids, which explains the different stereochemical outcome. The alternative binding mode identified in this study, accounts for the decarboxylation of 2-ethyl-2-vinyl malonate in outstanding stereoselectivity, a substrate that is not converted by wild-type AMDase. Our work sheds light on a new mechanism how enzymes can cleave C-C bonds without support of an organic cofactor. The gained mechanistic understanding will provide guidance for future protein engineering efforts.
Current Status and Progress in Integrative Treatment of Acute Ischemic Cerebrovascular Disease
Authors: Bian Zhe , Gao Jun , Zheng Fuxia , Wang Hui
Published: November 2024

Acute ischemic cerebrovascular disease (AICD) poses a severe threat to human health, characterized by high incidence and disability rates. Western medicine currently offers multiple treatment methods, such as thrombolysis, anticoagulation, and cerebral circulation improvement, while traditional Chinese medicine demonstrates unique advantages in herbal prescriptions, proprietary Chinese medicines, acupuncture, and massage therapies. Integrative treatment approaches combining Chinese and Western medicine have become widespread in clinical practice, yet challenges remain in optimizing specific treatment plans and elucidating mechanisms of action. This paper aims to comprehensively analyze the current status of integrative treatment for AICD, outline its developmental trajectory, and provide insights for enhancing treatment efficacy.
The Face of Resistance and Hope: An Autoethnographic Study on the Lived Experience of a Black Diversity and Equity Officers in Public School Education
Authors:   , Watkins Juanita
Published: November 2024

The purpose of this study is to illuminate the lived experiences of Diversity and Equity Officers (DEOs) in public school education. This study aims to provide readers with a better understanding of the various titles, duties, and organizational chart placements associated with these roles. It will also explore how Diversity and Equity Officers navigate challenges and obstacles, while finding opportunities for success. Additionally, this study seeks to comprehend the DEOs' authority and responsibilities, including their assessment and management of equity initiatives within the school system, and the influence of cultural capital on their functions and domains of influence. Using the Critical Race Theory conceptual framework and the Sensemaking method, this study will examine the impact of racism and racial undertones on these roles.
Histologic and immunohistochemical analysis of connective tissue changes in patients with intestinal sutures failure
Authors: Usenko O. Yu. , Voitiv Ya. Yu. , Dyadyk O. O. , Makarov V. I.
Published: November 2024

Objective. To determine the role of connective tissue pathology in the development of intestinal suture failure in order to improve the results of treatment of patients with this complication.
Materials and methods. The study included 45 patients with intestinal suture failure who were treated at the Shalimov National Research Center for Surgery and Transplantation of the National Academy of Medical Sciences of Ukraine in 2017–2023.
Results. A comprehensive study of fragments of small and large intestine tissues revealed similar morphological changes in patients with phenotypic signs of undifferentiated connective tissue dysplasia and intestinal sutures failure. Immunohistochemical examination of tissues with monoclonal antibodies to α–smooth muscle actin in both groups of patients revealed uneven, focal expression in smooth muscle differentiation cells and fibroblasts; with monoclonal antibodies to type IV collagen – moderate positive expression in the basal membrane of blood vessels, in smooth muscle cells of the muscle layer of the vessel wall, in areas of connective tissue, which meant pathological remodeling of connective tissue.
Conclusions. The similar results of histological and immunohistochemical studies in patients with signs of undifferentiated connective tissue dysplasia and intestinal sutures failure confirm the influence of connective tissue pathology on the development of this complication.
STRUCTURAL RESEARCH OF LI DOPED ZNO POWDERS
Authors: Shestakov M.V. , Gippius A.A. , Baranov А.N.
Published: November 2024

In this article, a series of Li-doped ZnO powders was prepared by melt growth from salt mixtures and investigated by means of Mass-Spectrometry (MS), Scanning Electron Microscopy (SEM), Powder X-Ray Diffraction (PXRD), Raman, Photoluminescence (PL) and Nuclear Magnetic Resonance (NMR) spectroscopies. The MS found that the Li concentration fell into the range from 0.87 to 3.31 atomic % for the prepared Li-doped powders. The powders constituted of slightly elongated particles, covering broad range from hundred nanometres to couple micrometres, as shown by SEM. The PXRD showed that the particles of all powders crystallized in the wurtzite (ZnO) structure with no impurities. The Rietveld analysis found that Li occupied octahedral interstitial positions in the ZnO lattice, together with the contraction of the lattice parameters a and c by 0.09 % and 0.13 %, respectively, upon doping with 1 % of Li ions. The Raman spectra exhibited A1(LO) and E1(LO) peaks absent in the undoped sample, supporting the Li incorporation into the ZnO lattice. The PL spectra of Li-doped samples exhibited a visible (~2.15 eV) and near infrared (~1.63 eV) luminescent bands associated with intrinsic defects and Li-Li nanoclusters, respectively. The presence of octahedral Li site along with multiple scattered Li sites was proved with almost zero electric field gradient (EFG) originating from octahedral voids in the wurtzite and various non-zero EFG in course of NMR measurement. Finally, the conducted structural research confirmed incorporation of Li into octahedral interstitials of the ZnO lattice supporting possible formation of Li-Li nanoclusters luminescent in the near infrared range.
Структурное семейство курчатовита CaMg[B2O5]: особенности строения, сложность политипов, DFT-анализ и сравнительная кристаллохимия пироборатов двухвалентных катионов
Authors: Аксенов С.М. , Банару Д.А. , Банару А.М. , Антонов А.А. , Кабанова Н.А. , Кузнецов А.Н. , Белоконева Е.Л. , Ямнова Н.А. , Дейнеко Д.В. , Червонная Н.А. , Чуканов Н.В. , Блатов В.А.
Published: November 2024

Среди большого числа слоистых неорганических соединений с модулярными структурами, для которых характерна политипия, особое место занимают природные и синтетические бораты. В данной работе повторно выполнен модулярный анализ кристаллических структур курчатовита и клинокурчатовита CaMg[B2O5] с использованием формализма OD-теории, топологический анализ геометрии и сложности кристаллических структур политипов, а также проведена их оптимизация методами квантовой химии. На основе полученных данных по строению курчатовита и клинокурчатовита, а также SrCd[B2O5], был подтвержден политипный характер строения данных соединений. Полученные теоретические и экспериментальные ИК-спектры находятся в полном согласии друг с другом для клинокурчатовита. Для политипных структур ИК-спектр может, в какой-то степени, рассматриваться как эмпирическая мера сложности структуры: чем ниже симметрия и чем больше колебательных степеней свободы на ячейку, тем больше нормальных мод. Сравнительный кристаллохимический анализ также позволил выявить симметрийное родство между большим числом пироборатов двухвалентных катионов с общей формулой M2+2[B2O5] (M = Ca, Sr, Pb, Mg, Mn–Ni, Zn, Cd), которые также можно объединить в единой структурное OD-семейство шимазакиита (или Cd2[B2O5]), которое состоит из трех типов OD-слоев.
IDENTIFYING PATTERNS & TRENDS IN ELDER FINANCIAL EXPLOITATION: AN ANALYSIS OF NEWSPAPER ARTICLES
Authors: Toste Keith
Published: November 2024

This study analyzed 102 newspaper articles on elder financial exploitation (EFE) from 2018 to 2023, revealing that media coverage primarily focused on scams and white-collar crimes, neglecting other types of financial abuse. It found that elderly women living alone with cognitive impairments were most affected. Through qualitative and quantitative analysis, the study identified key patterns and demographic details but highlighted the need for more balanced media representation. Recommendations include targeted policy interventions and increased collaboration among policymakers, law enforcement, and advocacy groups. Future research should explore EFE in cultural contexts over time to better inform prevention strategies.
“SATURN IS ALMOST INVISIBLE” (THE UNKNOWN SEMINARY)
Authors:   The Veteran Counterterrorism Centre, Kuznetsov Vladimir N. , Mazin Konstantin A. ,   Russian State University for the Humanities
Published: November 2024

The article analyses the history of the Tokyo Orthodox seminary, established in 1875 at the Russian Orthodox Mission in Japan (the Russian Spiritual Mission to Japan). The study was inspired by the most interesting document that was found by one of the authors of the article in the State Archives of the Russian Federation while examining the archival fund of the well-known church figure Archpriest P.I. Bulgakov (GA RF, F. Р597, Inv. 1, D. 135). The document is entitled “The School of the Imperial Russian Orthodox (Tikhon) Church for Educating Japanese Spies” and signed with a penname of “Ivan Goremyka” (Luckless Ivan). It considers from a completely new perspective the activities of the Tokyo Seminary, which in Russian historiography has always been positioned as one of the highest achievements of the “soft power” exercised to promote the Russian influence on the Japanese archipelago. Such an approach necessitated a thorough analysis of all the aspects of the functioning of the described educational institution, to which most of the proposed article is addressed. Special attention is given to the activities of seminarians after seminary graduation and the extent to which mission leaders are held accountable for the charges. A special attention is given to the seminarian activities after the graduation from the Seminary as well as to the degree of responsibility of the Mission leaders for the accusations brought against them. It should be mentioned that the noninvolvement (except for some naivety) of Saint Nicholai of Japan, the Primate of Eastern Orthodoxy in Japan, glorified as Equal-to-the-Apostles (secular name Ivan Dmitrovich Kasatkin) was questioned neither by the “whistle-blower” himself nor by any other representative of the Russian colony in Tokyo. However, his successor as the ruling bishop of the Japanese Orthodox mission Sergii (secular name Georgiy Alexeyevich Tikhomirov) aroused certain suspicions, so that “Ivan Goremyka” merely accused him of aiding the Japanese intelligence agencies. Finally the authors came to the conclusion that despite being too negative and categorical, “Ivan Goremyka’s” arguments are not far from the truth: indeed, the Japanese authorities somehow managed to even use the Russian Orthodox seminary in their anti-Russian actions. The article considers separately the fate of the Russian seminarians, the father of the Russian Sambo martial art V.S. Oshchepkov among them, who helped the Russian counterintelligence in its attempts to mitigate the negative aspects in the activity of the Seminary.
THE LÜBECK MAGISTRATE 1594 OPEN LETTERS FROM THE RUSSIAN STATE ARCHIVES OF ANCIENT DOCUMENTS
Authors:   Yaroslav-the-Wise Novgorod State University, Ushakov Artem V.
Published: November 2024

The article describes 16 open letters of the Lübeck City Council, kept in the Russian State Archives of Ancient Documents, and issued to the Hanseatic merchants travelling to Russia, and confirming the Hanseatic origin of the goods transported across the border. The contents of the open letters are analyzed to identify the main features of the Russian-Hanseatic trade after the end of the Livonian War and before the signing of the Trade Peace Agreement of 1603, which established the rules of the Hanseatic-Russian commodity exchange and the list of the German merchants’ privileges in the Russian markets. Much attention is paid directly to the merchants who were given the open letters to determine their connection with the Corporation of Lübeck’s “Novgorod guests” (Nowgorodfahrer), a Lübeck burghers’ large commercial association that occupied an important place in the Russian–Hanseatic trade of the late Middle Ages and the early Modern Times. The subject of research in that respect were manuscript materials from the Archives of the Hanseatic city of Lübeck have become the subject of the research work. Moreover, the 1594 open letters of the Lübeck Magistrate from the Russian State Archives of Ancient Documents are compared with the similar documents of the period under review from the Tallinn City Archives. The original text of one of the open letters is appended to the article, as well as the drawings of the possessory signs of the Hanseatic merchants depicted in the studied handwritten sources.
A MIX OF TRIBES AND PEOPLES OF EMPIRES. ABOUT THE REFERENCE BOOK “PRISONERS OF WAR OF THE FIRST WORLD WAR. AN INTER-FUND NAME INDEX TO THE METRIC BOOKS OF THE TEMPLES OF THE OMSK REGION (1914-1920)”
Authors:   Omsk State Technical University, Nazyrova Viktoria V.
Published: November 2024

The article analyzes the scientific reference publication “Prisoners of war of the First World War. An inter-fund name index to the metric books of the temples of the Omsk region (1914–1920)”. The work was prepared as part of the book series “Open Archive”. Based on the study and analysis of the act records of the metric books kept in the Historical Archives of the Omsk region, biographical information was collected with the search data for the documents on the military personnel of the German and AustroHungarian armies who were prisoners of war in the Omsk region in 1914– 1920. The publication presents the data from the civil records of the metric books of the Omsk Ecclesiastical Consistory, the Omsk Roman Catholic Parish Church, the Omsk Evangelical Lutheran Church and the Synagogue of the Omsk Jewish Society. Turning of the authors’ team to the study of the church documents for understanding the social and political processes seems justified in connection with the special role of the religious factor in the military revolutionary period. The publication contains detailed biographical data, and a personal search record is compiled for each person. It is noted that the procedure described by the Omsk researchers can be adopted by other archival institutions. The analyzed church records open up new opportunities for studying the specific pages in the history of the First World War and expand the possibilities for biographical (genealogical) search.
Assessment of the modification of the authorisation of the feed additive consisting of Saccharomyces cerevisiae CNCM I‐1077 for lambs and its extension of use to all ruminants and camelids reared for milk production/suckling/reproduction, all minor (young) ruminant species and camelids for fattening and Equidae other than horses (Lallemand SAS)
Authors:   EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Villa Roberto Edoardo , Azimonti Giovanna , Bonos Eleftherios , Christensen Henrik , Durjava Mojca , Dusemund Birgit , Gehring Ronette , Glandorf Boet , Kouba Maryline , López‐Alonso Marta , Marcon Francesca , Nebbia Carlo , Pechová Alena , Prieto‐Maradona Miguel , Röhe Ilen , Theodoridou Katerina , Woutersen Ruud , Anguita Montserrat , Brozzi Rosella , Galobart Jaume , Innocenti Matteo L. , Pagés Daniel
Published: November 2024

Abstract
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of a preparation of Saccharomyces cerevisiae CNCM I‐1077 as a zootechnical feed additive for several animal species. The additive, existing in a not‐coated and a coated form, is currently authorised for use in feed for calves, cattle for fattening, dairy cows, dairy goats and dairy sheep, lambs, all minor ruminant species for fattening and rearing, horses and camelids for fattening and rearing. This application regards the request for the extension of use in all ruminants and camelids reared for milk production/suckling/reproduction, all minor (young) ruminant species and camelids for fattening and Equidae other than horses, and the modification of the authorisation for lambs to reduce the minimum use level. The identity of the active agent as S. cerevisiae was confirmed. Based on the qualified presumption of safety approach and since no concerns are expected from other components, the additive is considered safe for the target species, consumers and the environment. The not‐coated form of the additive is not irritant to skin or eyes. The additive in both formulations should be considered a skin and respiratory sensitiser and any exposure through skin and respiratory tract is considered a risk. No conclusion could be drawn on the eye irritation potential of the coated form of the additive due to the lack of data. The additive has the potential to be efficacious when used in feed for all ruminants and camelids reared for milk production/suckling/reproduction at the minimum proposed use level of 5 × 108 CFU (colony forming unit)/kg complete feed, all minor (young) ruminant species and camelids for fattening and lambs at 1 × 109 CFU/kg complete feed, and in all Equidae species other than horses at 3 × 109 CFU/kg complete feed.
THE PARADIGM SHIFT FROM PRINT TO DIGITAL MEDIA: AN EVALUATIVE STUDY
Authors: Rai Vinay Kumar
Published: November 2024

The relevance of media is increasing daily as it connects the globe and enables us to evaluate every piece of information, we get daily. At present, media may be classified into three segments- Print Media, Electronic Media and Digital Media. These all have their own opinions, importance and uniqueness. Media consumption is undergoing a significant shift in consumption patterns. Digital media with the help of technologies and the digital transformation now plays a significant role in every industry, including business, education, politics, medicine, marketing, and communication. The transition of the news media to digital has caused significant change in the industry, including several of new providers. This paper focuses on impact of digital media on print media and how it created a physical and digital space. The following aims to provide information regarding the digital transformation by conducting a systematic literature review.
SKILLING INDIA'S YOUTH FOR A DIGITAL ECONOMY CHALLENGES AND OPPORTUNITIES IN THE EVOLVING JOB MARKET
Authors: Pasha Mahiboob
Published: November 2024

India, with its vast and dynamic youth population, stands at the threshold of a significant economic transformation driven by rapid digitalization. This research paper explores the challenges and opportunities involved in skilling India's youth to align with the evolving demands of a digital economy. It highlights key issues such as the digital skills gap, accessibility to quality training programs, and regional disparities. Additionally, it examines the potential of government initiatives, public-private partnerships, and educational reforms in addressing these challenges. The paper also emphasizes the role of emerging technologies, such as artificial intelligence, blockchain, and data analytics, in reshaping job roles and creating new career paths. By assessing current frameworks and providing policy recommendations, this study aims to contribute to strategies that will empower India’s youth to thrive in a digital future.
THE ROLE OF HIGHER EDUCATION IN IMPROVING WOMEN’S HEALTH
Authors: Jyoti  , Rani Anju
Published: November 2024

As the primary United Nations (UN) framework for achieving "integrated and indivisible" goals across the three distinctive components of sustainable development—the social, environmental, and economic—the 2030 Agenda for Sustainable Development entered into force in January 2016. Health and well-being are a social dimension and the third goal of SDG. Although men and women have different healthcare needs, both have a right to lead healthy lives. However, due to issues like scarce financial resources and travel constraints, gender prejudice continually prevents many women and girls from accessing health care. By 2030, the SDG aims to globally reduce maternal mortality to fewer than 70 per 100,000 live births. By 2030, make sure that everyone has access to family planning, information, education, and the inclusion of reproductive health into national plans and activities. Education is typically considered a resource at the individual level by health researchers. However, within social connections, education is probably both an intra-individual and an inter-individual health resource. The inclusion of personal hygiene teachings in the school curricula, as well as free and universal compulsory education, which has resulted in widespread literacy, has greatly increased women's knowledge of health issues. In this paper, the main topic is the effect of education on women's health. The amount of newborn and child mortality, maternal mortality, communicable and non-communicable diseases, and awareness of all types of health issues are significantly influenced by women's education. Almost all of the other goals are influenced by health and education, which are the subjects of SDG 3 and SDG 4, which are both focused on health and well-being. For instance, universal health coverage (UHC) can help reduce poverty (SDG 1) by protecting individuals from a significant source of financial hardship, and good health can promote increased employment and economic growth (SDG 8). Strong healthcare systems can shield citizens from the negative social and financial effects of epidemics and other medical emergencies. Therefore, this essay aims to explain how higher education contributes to the long-term health and well-being of women in Haryana.
COMPARATIVE STUDY OF PRIMARY SCHOOL ADMINISTRATORS' PERSPECTIVES ON INCLUSIVE EDUCATION OF DIFFERENTLY ABLED CHILDREN IN INDIA AND UZBEKISTAN
Authors: Ikrom Kizi Tolipova Ranokhon , M Harikrishnan
Published: November 2024

The purpose of this study is to examine the current state of attitudes and practices of primary school administrators concerning inclusive education in two different countries Delhi, India and Tashkent, Uzbekistan with a comparative cross-sectional research design. The study seeks to establish the perception that the administrators have towards children with disabilities in regular schools as well as the factors that influence the perception. The purpose of the study is therefore to establish similarities and/or differences in the perceptions and practices of administrators from the two culturally and educationally distinct cities with regard to inclusive education.
The participants were primary school administrators from public and government schools in Delhi and Tashkent to target the key persons responsible for supporting and coordinating inclusion in the schools. The sample was chosen with 677 male and 453 female administrators and 780 participants from Delhi, and 350 from Tashkent which provides a good mix of the participants’ views from different regions. The data were collected through survey; the questionnaire included questions on attitudes towards inclusion, training received, knowledge of policies in relation to inclusion, support and barriers.
 When the data was analyzed using SPSS software, it was found that there was a statistically significant difference in attitudes between the administrators in Delhi and those in Tashkent. Even with the similar training frequency in both the cities, the total training results are still unsatisfactory, which shows the requirement for more effective professional development. It also revealed that there were significant differences in the perceived availability of support systems and the challenges that were faced, which show that the regional policies and resource allocation have a big influence on the success of inclusive education.
 There was a difference in the perception among male and female administrators with the female administrators perceiving a higher impact of inclusive education and identifying more areas of need. These findings underscore the value of the contextualized approaches that take into consideration the particularities of various geographical and population settings.
INFLUENCE OF VAISNAVISM ON THE MISING COMMUNITY OF ASSAM
Authors: Pegu Popy
Published: November 2024

The Mising, officially known as Miri, is the second largest tribal group in Assam. Originally, they lived in the hills, particularly in the Siang valley of Arunachal Pradesh, but around the 13th century A.D., they migrated to the plains of Assam. It has been seen that the traditional beliefs and practices of the Mising community have undergone significant changes over time. Among these changes, the influence of Vaisnavism stands out as particularly prominent. over the time, the Kal Sanghati, a group of Vaisnavism become popular among the Misings. On the basis of nature of practices, it divided the misings into two groups- Bhagavatia and Kewalia.
MULTIPLE FLYING OBJECT DETECTION USING MACHINE LEARNING ALGORITHM
Authors: Karthigavani N. , Tamilarasan R.M. , Thanish D. , Vignesh A.
Published: November 2024

Detecting multiple flying objects is a crucial task in various domains such as surveillance, wildlife monitoring, and airspace management. This paper presents an approach to detect multiple flying objects using object detection algorithms. The process involves several key steps, including data collection and annotation, preprocessing, model selection, training, evaluation, deployment, real-time detection, post-processing, and monitoring. Initially, a diverse dataset containing images or videos with various flying objects is gathered, and annotations are added to label each object with its corresponding class and bounding box coordinates. Preprocessing techniques like resizing, normalization, and augmentation are applied to enhance the dataset. Next, a suitable object detection algorithm is selected, considering factors like performance and computational efficiency. Common choices include YOLO model, depending on the specific requirements of the application. The chosen model is trained using the annotated dataset, fine-tuned, and evaluated using metrics like precision, recall, and mean Average Precision (mAP). Upon satisfactory performance, the model is deployed in the desired environment, integrated with appropriate hardware for real-time detection. Post-processing techniques such as non-maximum suppression (NMS) are applied to refine the detected bounding boxes, ensuring accurate identification of multiple flying objects. Regular monitoring and maintenance are conducted to keep the deployed model up-to-date and effective in dynamically changing environments
Patient Photographs and Google Images: An AI Ethics Case Study
Authors: Bhattacharjee Maushumi , Bagheri Ebrahim , Asaad Lauren , Marshall Zack
Published: November 2024

Over 35% of case reports published in medical journals contain patient photographs. With widespread online academic publishing, there is growing concern about patient photographs that were originally published in medical journals appearing in online image search results. Research has shown that from a random sample of case reports indexed in PubMed, at least one image was found on Google Images for 76.3% of the publications. Inspired by recent examples, this case study explores the ethical implications of patient photographs circulating outside of the original journal website, including attention to patient privacy and informed consent.
Optimizing the Family Assistance Team in Reducing Stunting in Padang City Based on Environment
Authors: Rismiati Rismiati , Syah Nurhasan , Dewata Indang , Barlian Eri
Published: November 2024

Based on the results of the research analysis, it can be concluded that the Family Assistance Team in reducing stunting in Padang City has performed optimally in carrying out the task of reducing stunting in Padang City. There are obstacles encountered by the Family Assistance Team in carrying out their duties, namelyoften changing midwives, it is difficult to adjust the data collection schedule, looking for families who are registered with the family assistance team but are not domiciled,There are several families who are not open to accepting us to visit their homes, the application often has errors, the public's awareness of checking their health is still low, the dual task of being an employee and the duties of the family assistance team, families not implementing the recommendations of the family assistance team.
Pentingnya Kemitraan Usaha Untuk Mencapai Keberhasilan Pemasaran Antar Wilayah Bagi Kwt Al-Ummahat Di Desa Lendang Nangka
Authors: Idiatul Fitri Danasari  , Sri Mulyawati  , Amuddin  , Dewi Anjani  , Baiq Neny Rafika Aprilia
Published: November 2024

Aspek pemasaran kerap menjadi permasalahan bagi pelaku UMKM di Indonesia. Salah satu strategi dalam mengatasi permasalahan pemasaran yang terjadi yaitu melalui penjalinan kemitraan dengan pihak tertentu. Kemitraan dapat menjadi salah satu strategi bisnis dalam jangka waktu tertentu untuk mendapatkan keuntungan bersama dengan prinsip membutuhkan, memperkuat, dan menguntungkan. KWT Al-Ummahat sebagai salah satu KWT Produktif di Desa Lendang Nangka juga mengalami permasalahan pada aspek pemasaran yang masih mencakup konsumen lokal sehingga dilakukan sosialisasi penjalinan kemitraan untuk mencapai keberhasilan pemasaran antar wilayah/kabupaten. Kegiatan pengabdian sosialisasi kemitraan usaha dilaksanakan melalui tahapan persiapan, sosialisasi, serta monitoring dan evaluasi dengan kelompok sasaran KWT Al-Ummahat sebanyak 20 orang yang merupakan pelaku usaha VCO di Desa Lendang Nangka. Hasil pelaksanaan dan evaluasi menunjukkan bahwa adanya peningkatan pengetahuan dan motivasi peserta untuk menjalin skema kemitraan usaha atau dagang dengan mitra NTB Mall. Melalui skema kemitraan ini diharapkan dapat mencapai keberhasilan pemasaran produk VCO KWT Al-Ummahat hingga antar wilayah/kabupaten. Dalam rangka menjadi mitra dagang NTB Mall Provinsi NTB, pihak KWT Al-Ummahat masih perlu memenuhi syarat administrasi yang telah ditetapkan oleh pihak NTB Mall.
Between continuity and change: A longitudinal analysis of Swedish local government digitalization strategies
Authors: Rizk Aya , Sundberg Leif , Heidlund Marcus , Toll Daniel
Published: November 2024

The terminology associated with the use of information and communication technologies in the public sector has shifted over time, from information technology to digitalization. This change raises the question of whether corresponding shifts in government practices have accompanied it. To investigate this issue, we use topic modeling to analyze a corpus of IT- and digitalization strategies from Swedish local governments, produced over three decades. Our analysis reveals salient topics covered in these strategies and classifies them, displaying patterns of both continuity and change. Some of these patterns reflect dominant discourses about technological governance and the provision of digital services based on citizens’ needs, but there is also a notable absence of content related to democracy and participatory practices. Taken together, our study contributes empirically with an evolutionary perspective on digital government strategies and methodologically with the adoption of computational methods for this purpose.
Frontline workers’ role in digital self-service co-production: Channel promoters, digital helpers, or intermediators
Authors: Höglund Rydén Hanne , Hofmann Sara
Published: November 2024

When public services move online, citizens are expected to serve themselves on digital platforms and enrol in public services through self-service procedures. In this digital encounter, many citizens struggle to live up to the “self” in self-services and seek in-person assistance from public professionals. These professional actors play an essential role in enabling the co-production of self-services for citizens who struggle to be truly self-serving. This article explores the frontline workers’ roles in self-service co-production when interacting with citizens seeking help in the service procedures. Service interactions have been studied in two meeting centres of the Norwegian Labor and Welfare Administration. We have conducted observations of office interactions in general and at digital self-service stations in particular. Interviews with public officials have complemented these observations. We use intermediation and co-production theory as analytical lenses in our data analysis. The findings show that the role of frontline workers can be both flexible and narrow in nature and that they take on the role of intermediaries when acting as a bridge between the analogue world and the digital domain. We also see that the intermediating role frontline workers take will vary and is influenced by organisational, personal, and external circumstances that can enable or restrain the co-production of self-services.
COMPORTAMENTO PREVENTIVO DE SERVIDORES DA UEM HIPERTENSOS E A ADERÉNCIA AO PROGRAMA DE ASSISTÉNCIA AO HIPERTENSO DO AMBULATORIO
Authors: SILVA MARCON SONIA , VALSECHI ELIZABETH , TORRE SILVA REGINA LUCIA , PAGLIARINI WAIDMAN MARIA ANGELICA
Published: November 2024

Estudo descritivo exploratorio cujo objetivo foi identificar nos empregados de UEM inscritos no Programa de Assisténcia ao Hipertenso do Ambulatorio, as variáveis do modelo de crenpa na saúde que interferem positiva ou negativamente, na adopao de apees que caracterizam um comportamento na saúde, representado pela aderéncia au Programa. O estudo foi realizado em 41 individuos (80,4%) seleccionados pela técnica de mostras nao probabilística. Os resultados demostraram que a maioria dos individuos adotam um comportamento preventivo, que as variáveis suscetibilidade, gravidade, beneficios percebidos e eventos motivadores, mostraram muita e media importancia nesta adopáo, sendo que os hábitos de vida mais alterados estáo relacionados com a alimentapáo, tabaco e bebida alcólica.
EFECTO DE UN PROGRAMA EDUCATIVO REFORZADO EN LA CONDUCTA AUTOEXAMINADORA DE MAMA DE PROFESORAS DE LICEOS DE NIÑAS. CONCEPCION, CHILE
Authors: SANHUEZA ALVARADO OLIVIA INES
Published: November 2024

Estudio experimental, basado en el Modelo de Creencias en Salud, a fin de verificar que un Programa Educativo Reforzado (P.E.R.) respecto a cáncer y autoexamen de mamas, dado a profesoras de enseñanza media, cambiaría favorablemente su conducta autoexaminadora de mama. Esta conducta fue medida a través de cinco variables: percepción de susceptibilidad y percepción de gravedad del cáncer mamario; nivel de conocimientos; frecuencia de práctica del autoexamen y el dominio. Estas variables se evaluaron tanto en el grupo de profesoras al que se le aplicó el PER como en el grupo que no se aplicó. Se utilizaron instrumentos de autora para estudiar conocimientos, dominio y práctica del autoexamen. Para las percepciones de susceptibilidad y de gravedad las escalas de V. L. Champion (1984). El análisis de los datos permitió la aceptación de las hipótesis, concluyéndose que el Programa Educativo habría sido determinante en producir cambios favorables en la conducta de autoexamen de las profesoras.