bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect Of Using Chicken Egg Emulsifier And Duck Eggs On The Quality Of Ice Cream
Authors: Octaliandra Selly , Holinesti Rahmi
Published: May 2023

Ice cream is a product derived from dairy processing and has a semi-solid texture and is consumed frozen. One of the most important ingredients in the manufacture of ice cream is emulsifier. Emulsifier consist of two types, namely natural emulsifiers and artificial (synthetic) emulsifiers. Artificial or synthetic emulsifiers come from human engineering, namely engineered fats while natural emulsifiers usually come from nature such as egg yolks. The use of egg yolks with the right concentration can increase the viscosity, texture and consumer liking. This study aims to analyze the quality of ice cream using an emulsifier from chicken eggs and duck eggs on the quality of color, aroma, texture, and taste of ice cream. This type of research is a pure experiment with a completely randomized design method (CRD) by studying two treatments X1 (duck egg yolk), X2 (chicken egg yolk) with 3 repetitions. The data collection technique was carried out by conducting an organoleptic test involving five expert panelists who were Lecturers of Catering Department of Family Welfare, Faculty of Tourism, Hospitality, Padang State University. The results obtained from the organoleptic test will be continued with statistical analysis using the T test. The results show that there are significant differences in the quality of color, aroma and taste in ice cream and there is no effect on the quality of texture. The best results were found in the X1 treatment, namely the use of duck eggs on the quality of ice cream
RE-IMAGINING MODEL GEREJA KONTEKSTUAL YANG LIBERATIF DI ASIA DENGAN INSPIRASI TEOLOGIS DARI CHOAN-SENG SONG DAN AHN BYUNG-MU
Authors:   Program Magister Filsafat Keilahian, Fakultas Teologi Universitas Sanata Dharma Yogyakarta, Kristanto Harry
Published: May 2023

At the same time as the sense of solidarity among Asian Churches is growing through Federation of Asian Bishop Conference (FABC), the effort to understand what it means to be a Church in Asia becomes more profound. We can mention several theological approaches which trying to reconstruct a distinctive face of the Asian Church, for example Choan-Seng Song who develops contextual theology with a transpositional mode. Starting from his critical position against the tendency of Western-centered nature of Christian theology, Song raised four important elements in a reorientation towards contextual theological exploration, namely vision, community, passion, and "imagi-nation". Besides him, it is also appropriate for us to review the efforts of South Korean theologians, especially Ahn Byung-Mu, in proposing Minjung Theology. For Ahn, a contextual theology should also be liberative. The two theological ideas of contextual-liberative Church above are prompting us to continuously imagine and strive for an Asian ecclesiology, especially in Indonesia.
PENGGUNAAN KITAB SUCI AGAMA KRISTEN (ALKITAB) DALAM RITUAL PENGOBATAN DI MINAHASA
Authors:   Magister Sosiologi Agama, Universitas Kristen Satya Wacana Salatiga, Supit Ruland , Welem Theofilus ,   Magister Sosiologi Agama, Universitas Kristen Satya Wacana Salatiga
Published: May 2023

The purpose of this paper is to explain the use of the holy book (Bible) in the healing rituals performed by the Tona'as in Minahasa, and aims for several groups of local belief adherents in Minahasa to carry out healing rituals that use the holy book and those who do not use the holy book and There are pros and cons in healing rituals. In the experience of the Minahasa people, the use of religious books in the process of carrying out healing rituals has had pros and cons, but this problematic situation has not made religious books disappear in the implementation of rituals. Religious books cannot be separated from sacred reality, because almost all religions have beliefs about the sacred and that belief grows through religious books as a foundation for understanding various religious realities. The theoretical approach that will be used as material for analysis is the theory of religious texts, ideology, culture and community and will also use the theory of rituals from Catherine Bell and some of the severe opinions of sociologists regarding rituals. The research method used is a qualitative method with a phenomenological approach. The results of the study show that the ritual process which includes Christian religious books, namely the Bible, is a separate way for the local community to construct their beliefs by understanding that there is a sacredization in the ritual process.
VIRTUE EDUCATION IN SUFFERING FROM SEXUAL VIOLENCE
Authors:   Universitas Atma Jaya Yogyakarta, Suryanti Chatarina , Reno Sitepu Roberto ,   Universitas Atma Jaya Yogyakarta
Published: May 2023

Is education on theological virtues and moral virtues still relevant to help victims of sexual violence? This article was written to see the importance of education on theological and moral virtues to help victims of sexual violence. The method used for research includes descriptive qualitative research which is carried out by combining field research and literature. Based on the research conducted, it was found that all respondents stated that education on theological virtues and moral virtues was still relevant to helping sufferers because of sexual violence. Therefore, a concept of personal theological and moral virtue is needed as a strategy to maintain and develop the integrity of creation and to experience oneself as the image of God.
The Quality of Malaysian Clinical Practice Guidelines and Relevance to The Care of Older People
Authors:   Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), 42300 Bandar Puncak Alam, Selangor, Malaysia, Mohd Nawi Nadzihah , Gnanasan Shubashini , Abd Wahab Mohd Shahezwan , Karuppannan Mahmathi ,   2Department of Pharmacy Practice, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), 42300 Bandar Puncak Alam, Selangor, Malaysia
Published: May 2023

Clinical Practice Guidelines (CPGs) are key instruments in providing the most appropriate decision in the treatment of any disease. CPG was developed to improve health care by increasing the incorporation of evidence-based treatments to reduce the use of unnecessary, ineffective or harmful interventions. This study assessed 5 Malaysian CPGs using Appraisal of Guidelines Research and Evaluation II (AGREE-II) instrument which could help the stakeholders to decide if further improvement or modification is needed. AGREE-II is an international instrument that aids in CPG development. It comprises of 23-items under 6 different domains. The κ statistics was used to look for agreement between 3 appraisers across these domains. The relevance of the Malaysian CPG to the care of older people in this study was also assessed using an instrument that have been developed by a previous study (Quality of Australian clinical guidelines and relevance to the care of older people with multiple comorbid conditions). This instrument evaluated if the guidelines addressed the treatment for older people, the burdens to the patients and caregivers as well as patient-centered aspects such as patients’ preferences and their quality of life. This study showed that all 5 Malaysian CPGs are of good quality and acceptable to clinical settings according to the AGREE instrument. However, it was found that none of the CPG considered patients’ preferences in developing CPGs. In terms of the CPGs’ relevance to the care of older people, our results showed that there is poor relevance on the patients’ burden of treatment. Only two CPGs (Management of Type 2 Diabetes Mellitus and Management of Hypertension) had a higher agreement between the appraisers compared to other CPGs in relation to management of medical conditions in older patients. As a conclusion it was found all 5 Malaysian CPGs evaluated were in good quality but need improvement in terms of involving stakeholder in the development of CPGs at par with other developed countries.
Additions and corrections to the checklist of true bugs of Hungary (Hemiptera: Heteroptera)
Authors: Torma Attila , Rédei Dávid
Published: May 2023

The checklist of the Heteroptera fauna of Hungary is complemented. Xylocoris (Stictosynechia) lativentris (J. Sahlberg, 1870) (Anthocoridae), Orsillus maculatus (Fieber, 1861) (Lygaeidae) and Ochetostethus balcanicus (Wagner, 1940) (Cydnidae) are reported as new species to the fauna of Hungary. Re-examination of voucher specimens concluded that the following species were recorded from Hungary by misidentified specimens only, therefore these are deleted from the Hungarian checklist: Scutelleridae: Odontotarsus robustus Jakovlev, 1884; Pentatomidae: Neottiglossa lineolata (Mulsant and Rey, 1852). Species previously recorded from Hungary but erroneously omitted from the latest published checklist are discussed as well.
Collection data to North Africa’s (Morocco, Algeria, Tunisia) leaf beetle fauna (Coleoptera: Chrysomelidae)
Authors: Rozner István , Rozner György
Published: May 2023

In this article we discuss the data on the collecting trips to Morocco in 1982 and in 2008, to Algeria in 1986 and in 1990, and in Tunisia in 1995. These collections comprise 112 species in 37 genera. Amongst these 4 (Cryptocephalus macellus Suffrian, 1860, Prasocuris junci (Brahm, 1790), Psylliodes maroccanus Heikertinger, 1916, Cassida humeralis Kraatz, 1874 ), represent new records to the Algerian fauna and one species Coptocephala unicolor (Lucas, 1845) is a new record to the Tunisian fauna.
A Scythris buszkoi Baran, 2004 elterjedése és biológiája a Pannon régióban (Lepidoptera: Scythrididae)
Authors: Fazekas Imre
Published: May 2023

The occurrence of Scythris buszkoi Baran, 2004 in Hungary has been reported recently. The database is based on the collection of the Regiograf Institute and publications. The descriptive text mentions the distribution of the species, the occurrence in Pannonian Region, the most frequented habitats, the biology and pertinent literature. Habitats of the species are illustrated by some photographs and are discussed. The habitats are areas that are extensively used, lowland-, colline- and submontane areas: thermophilous woodland fringes; dry and semi-dry closed grasslands; semi-natural road verges, embankments and flood-control dams; large parks and botanical gardens with surviving native vegetation; arable land with fine soil, often low-intensity agriculture vegetation; fine soil vineyards and orchards; sand, clay and gravel quarries, bare loess cliffs; former goose grazing land and cemetery. The first generation flies from the end of April until June, the second one from July to the mid-September. According to the observations in the Hungarian and Slovakian populations the adults are the most active in the late morning hours and early afternoon. In cloudy weather they relax on the underside of the leaves. They come to light in the evening and at night and are also active by day. Distribution: Very local in Ukraine, Poland, Slovakia and Austria, widespread in Hungary. The moth absent from southern and western Europe and unknown outside Europe. With 10 figures.
SARS-COV-2 Infection in Children and Young People in Bulgaria – A Prospective, Single-Center, Cohort Study
Authors: Velikov P. , Kapincheva N. , Trifonova I. , Velev V. , Popov M. , Ivanov I. , Chipeva R. , Valkov T. , Yordanova R. , Dimitrov G. , Korsun N. , Tcherveniakova T.
Published: May 2023

Compared to other respiratory viruses, the proportion of hospitalizations due to SARS-CoV-2 among children is relatively low. While severe illness is not common among children and young individuals, a particular type of severe condition called multisystem inflammatory syndrome in children (MIS-C) has been reported. The aim of this prospective cohort study, which followed a group of individuals under the age of 19, was to examine the characteristics of patients who had contracted SARS-CoV-2, including their coexisting medical conditions, clinical symptoms, laboratory findings, and outcomes. The study also aimed to investigate the features of children who met the WHO case definition of MIS-C, as well as those who required intensive care. A total of 270 patients were included between March 2020 and December 2021. The eligible criteria were individuals between 0-18 with a confirmed SARS-CoV-2 infection at the Infectious Disease Hospital “Prof. Ivan Kirov” in Sofia, Bulgaria. Nearly 76% of the patients were ≤ 12 years old. In our study, at least one comorbidity was reported in 28.1% of the cases, with obesity being the most common one (8.9%). Less than 5% of children were transferred to an intensive care unit. We observed a statistically significant difference in the age groups, with children between 5 and 12 years old having a higher likelihood of requiring intensive care compared to other age groups. The median values of PaO2 and SatO2 were higher among patients admitted to the standard ward, while the values of granulocytes and C-reactive protein were higher among those transferred to the intensive care unit. Additionally, we identified 26 children who met the WHO case definition for MIS-C. Our study data supports the evidence of milder COVID-19 in children and young individuals as compared to adults. Older age groups were associated with higher incidence of both MIS-C and ICU admissions.
Risk Factors and Comorbidity in Patients with Bacterial Meningitis
Authors: Argirova P. , Kalchev Y. , Murdjeva M. , Stoycheva M.
Published: May 2023

Introduction. Bacterial meningitis is a severe disease with high mortality and frequent residual neurological sequelae. It is associated with multiple risk factors. The aim of the study was to establish the main risk factors associated with bacterial meningitis and to outline the incidence of chronic diseases in patients with bacterial meningitis and their relationship to the patients’ age and etiology of meningitis, if any.

Materials and methods. The study included 90 patients with bacterial meningitis admitted to the Clinic of Infectious Diseases, University Hospital “Sv. Georgi” – Plovdiv during the period January 1, 2016 – September 30, 2019. Epidemiological analyses, clinical examinations, laboratory and microbiological tests, and statistical methods were used.

Results. A total of 76.8% of patients had concomitant conditions: cardiovascular diseases (38.9%), diabetes mellitus (16.7%), immunosuppression (16.7%), liver diseases (11.1%), pulmonary diseases (10%), neoplasms (7.8%), chronic kidney diseases (7.8%). The incidence of immunosuppression (p = 0.009), cardiovascular disease (p = 0.0001), and diabetes (p = 0.009) were significantly higher in adults compared to children. Risk factors were present in 37.8% of patients (44% in children and 35.4% in adults, p > 0.05), especially in patients with pneumococcal meningitis (47.1%). The main risk factor was otitis or sinusitis in the last 3 months before meningitis (17.8%), followed by head trauma (6.7%), alcoholism (6.2%), recurrent episode of meningitis (4.4%), nasal leakage of cerebrospinal fluid (3.3%), general surgery (3.3%), and splenectomy (2.2%).

Conclusion. Elderly patients with meningitis had more frequent comorbidities than children, mostly cardiovascular diseases, diabetes, and immunosuppression. The highest incidence of chronic diseases was found in patients with listerial meningitis. Risk factors were found in both age groups.
Association of Insulin Resistance with Bone Mineral Density and Fracture Risk in Non-Diabetic Postmenopausal Women
Authors: Dimitrova R. , Hristozov K.
Published: May 2023

There is conflicting literature evidence regarding the independent effects of insulin resistance and concomitant hyperinsulinemia on bone mineral density. In addition, it is still under debate whether the net effect is favorable or unfavorable for the fracture risk. Therefore, we conducted a cross-sectional study.

Aim

To assess the correlation between bone mineral density and fracture risk with insulin resistance and circulating insulin levels in non-diabetic postmenopausal women.

Materials and methods

The study analyzed 84 women. The mean age of the participants was 60.54 ± 7.07 years, and the mean postmenopausal period was 11.45 ± 6.62 years. A standard oral glucose tolerance test was performed with measurement of blood glucose and insulin levels at 0 and 120 min. Dual-energy X-ray absorptiometry was used to determine bone mineral density at lumbar spine and proximal femur. Fracture risk was calculated using the Fracture Risk Assessment Tool.

Results

We found that in non-diabetic postmenopausal women lower basal insulin levels (fasting insulin) were associated with a higher 10-year risk of major osteoporotic fracture when insulin sensitivity was preserved (HOMA-IR index < 2). Fasting insulin levels under 6.15 μIU/ml were considered high-risk regarding the fracture risk. On the other hand, higher stimulated insulin levels at 120 min (post-load insulin) were associated with a higher 10-year risk of major osteoporotic fracture at HOMA-IR index greater than 2. Stimulated insulin levels above 39.7 μIU/ml were considered high-risk regarding the fracture risk.

Conclusion

Our results revealed a negative relationship between stimulated insulin levels at HOMA-IR index above 2 and bone integrity in postmenopausal age. On the other hand, higher basal insulin levels at HOMA-IR index lower than 2 were associated with better parameters of postmenopausal bone health.
Prevalence of Depression Among Employees in the Public Administration, Private and Industrial Sectors
Authors: Stancheva-Pargov N. , Stoyanova V.
Published: May 2023

Background

Symptoms of depressive disorder have been found to be particularly common among employees in the private administration, public, and industrial sectors.

Aims

This study aimed to assess the prevalence of depression among the specified groups of workers and to identify the main stressors that lead to symptoms of this condition.

Materials and methods

A self-administrated questionnaire was completed by respondents comprised of three groups of workers in the Republic of North Macedonia – Skopje. The survey assessed the sociodemographic characteristics and mental health (Patient Health Questonnaire-9). Logistic regression models were used to estimate associations between depressive symptoms and demographics, working environment and lifestyle parameters.

Results

The analysis of the total PHQ-9 score divided into two groups (≤ 10 and ≥ 10) indicated that 89% of the respondents had minimal/mild depression and 11% had moderate/severe depression. We have found a significant association between the group to which the respondent belongs and the degree of depression. Severe depression was significantly associated with work in public institutions.

Conclusion

Screening for depression among workers is necessary because of its high prevalence and high rates of underdiagnosis in the workplace. Early diagnosis and appropriate interventions are recommended, including actions focused on the risk factors for depression at the workplace.
Citizen Control in Primary Outpatient Care – Opportunities and Realities in Bulgaria
Authors: Zlatanova T. , Djuglarska M. , Popov N. A. , Shtereva-Tzоuni D. , Petrova-Gotova Ts. , Yaneva R. , Naseva E. , Lazarova M. , Stoyanova Ts. , Popov N. N.
Published: May 2023

The significance of control increases with the push towards improving the overall effectiveness of the health insurance system. In order for public resources to be spent lawfully and effectively, there needs to be increased control not only from the National Health Insurance Fund (NHIF), but citizen control also needs to be incorporated in the process.

Materials and Methods

The goal of this survey is to analyze the opportunities for implementing citizen control over the spending of public health funds and compare them to the real conditions as far as the outpatient medical care level. Legislation and news from NHIF’s webpage related to citizen control opportunities were studied. A direct, anonymous survey was carried out on the Google forms platform amongst Bulgarian citizens past the age of majority.

Results

The results of the questionnaire survey carried out between 24.06.2022 and 16.10.2022 among 1045 adults with compulsory health insurance from all over the country, showed that they were poorly informed on the opportunities for citizen control which have been regulated and created in practice and don’t take advantage of them. Only 45,6% of the participants were aware of the digital services “Record review for health-insured persons”, which is found on NHIF’s webpage, and less than half of them (42,8%) used this service. The NHIF’s mobile application for feedback was used by as little as 11,8% of the respondents, and only seven patients have used it to share an opinion, while nine have used it to get notifications for data changes in their patient record. The portion of participants who have taken part in NHIF inquiries was also very small – 2,5%. Merely 2,8% have posted a complaint to the NHIF after being denied medical services.

Conclusions

All of this makes it evident that a change is necessary in order for citizen control to be strengthened as a mechanism. This will lead to the correction of proven deviations in reported medical activities and will make it easier to get the patients’ opinions on the medical care they have been provided with.
Erythrodermic Psoriasis in Medico-Legal Practice: An Overview of a Case
Authors: Popa Ana Maria , Chivu Irina Alexandra , Popa Marius Florentin , Suceveanu Andra Iulia
Published: May 2023

Psoriasis represents a chronic autoimmune disease of great interest as its incidence has increased over the last decades. It encompasses a multitude of subtypes with various manifestations and complications. Erythrodermic psoriasis represents one of the most severe forms of the disease and is characterized by the appearance of a generalized erythematous rash on top of pre-existing lesions.

We present the case of a 71-year-old patient with history of arthropathic psoriasis who is admitted to the dermatovenerology clinic for deterioration of his general condition, exacerbated pre-existing cardiovascular conditions, a diffuse generalized erythematous skin rash, pronounced leg edema and nail changes. After following topical and systemic treatment, the patient was discharged in an improved condition. Two weeks later the woman is found dead in their home. An autopsy was performed and the necropsy examination describes the skin lesions presented before but in an aggravated form and the histopathological examination establishes the cause of death which is represented by acute heart failure, the consequence of lymphocytic interstitial myocarditis.

The particularity of the case is represented by the simultaneous exacerbation of cardiac and skin pathology, both having autoimmune components and an inflammatory substrate.
An Energy-Aware QoS Load Balance Scheduling Using Hybrid GAACO Algorithm for Cloud
Authors: Ilankumaran Arivumathi , Narayanan Swathi Jamjala
Published: May 2023

In recent days, resource allocation is considered to be a complex task in cloud systems. The heuristics models will allocate the resources efficiently in different machines. Then, the fitness function estimation plays a vital role in cloud load balancing, which is mainly used to minimize power consumption. The optimization technique is one of the most suitable options for solving load-balancing problems. This work mainly focuses on analyzing the impacts of using the Genetic Algorithm and Ant Colony Optimization (GAACO) technique for obtaining the optimal solution to efficiently balance the loads across the cloud systems. In addition to that, the GA and ACO are the kinds of object heuristic algorithms being proposed in the work to increase the number of servers that are operated with better energy efficiency. In this work, the main contribution of the GAACO algorithm is to reduce energy consumption, makespan time, response time, and degree of imbalance.
Investigation of Wastes Plastic and Glass to Enhance Physical - Mechanical Properties of Fired Clay Brick
Authors: Mohsin Rasool Dakhil , Al-Khazraji Hayder , Zemam Sajid Kamil , Majeed Tiba Hameed , Abbood Al-Zahraa Hayder
Published: May 2023

Around the world, large amounts of plastic and glass waste have been collected. This work is given as a way to reduce this material. This paper aims to investigate how fired clay bricks' physical and mechanical properties are affected by plastic/glass (P/G) powder. It is used as a replacement for clay, varying the plastic/glass content 00/20, 05/15, 10/10, 15/05, and 20/00 weight %. The ratio of soil to water remains constant 0.3. The maximum temperature is presented after three fire phases. The temperatures are 300 °C for the first, 600 °C for the second, and 900 °C for the third. Results for the physical properties showed an increase in the water absorption of clay brick specimens as the plastic content increased; in addition, efflorescence was increased with plastic powder. However, the density and firing shrinkage decrease with plastic quantity. Also, the experimental results showed a decrease in water absorption and efflorescence when the glass powder was increased. While the density is higher when glass powder is 20 %. According to the findings on mechanical properties, clay brick samples with higher plastic powder content 20 % displayed a decrease in compressive strength and flexural bending strength, i. e. the mechanical properties (compressive and flexural strengths) are increased with the increased
Analysis of the Shear Strength of a Soil-Geosynthetic Interface
Authors: Stacho Jakub , Sulovska Monika , Slavik Ivan
Published: May 2023

The paper presents the results of the shear strength measurements of a soil-geosynthetic interface. The tests were executed using a large-size direct shear test apparatus. A total of 5 different samples of materials were tested, i.e., ash, sand, well-graded gravel, fine poorly-graded gravel, and medium poorly-graded gravel. These materials were reinforced using different types of geosynthetics, i.e., Thrace WG80 black woven geotextile, Tencate Miragrid GX55/30 woven geogrid, and Thrace TG3030S rigid polypropylene geogrid. An interface coefficient α, which represents the ratio of the soil-geosynthetic interface shear strength to the shear strength of unreinforced material sample, was determined for given combination of the material and geosynthetics. The coefficient α reached a greater value in the critical stress state than in the peak stress state for sands and gravels reinforced using GX55/30 and TG3030S geogrids. The value of the coefficient α was in a range of 0.87 - 1.04 for gravels and 1.03 - 1.19 for sand. The black woven geotextile was used as the reinforcement only in samples of sand and ash. The results pointed to the different behaviour of these materials in the testing of the interface shear strength.
Temporal response of urban soil water content in relation to the rainfall and throughfall dynamics in the open and below the trees
Authors: Zabret Katarina , Lebar Klaudija , Šraj Mojca
Published: May 2023

Rainfall interception process is an important part of the biohydrological cycle, in which vegetation plays an important role by regulating the amount and dynamics of rainfall reaching the ground. In this paper, an event-based analysis is performed to discuss the influence of vegetation on dynamic of temporal response of soil volumetric water content (VWC) in the upper soil layer during rainfall events. More specifically, six events that occurred between 19 November 2021 and 30 June 2022, characterized by different hydro-meteorological and vegetation conditions, are analyzed based on continuous measurements of VWC in the open and below groups of two deciduous (Betula pendula Roth.) and two coniferous trees (Pinus nigra Arnold), as well as rainfall in the open and throughfall on an urban experimental plot in Ljubljana, Slovenia. VWC values at the upper depth (16 cm) were the highest under the birch tree, followed by the location in the open and under the pine tree. However, in the lowest depth (74 cm) VWC values were the lowest under the birch tree. VWC responses to rainfall and throughfall showed seasonal patterns related to the pre-event wetness conditions, with a faster occurrence of maximum VWC values in the leafless period. Additionally, rainfall amount and its dynamics during the event significantly affect the response, as VWC in general reaches its peak after the occurrence of more intense rainfall. Such an event-based analysis, offering an insight into the dynamics of the event development, is crucial and very beneficial for understanding of the biohydrological processes.
Is There any Obvious Relationship Between Taxation and Economic Growth?
Authors: Crăciun Andreea-Florentina , Răcătăian Raluca-Ioana , Țăran Alexandra-Mădălina , Moldovan Nicoleta-Claudia
Published: May 2023

In an economy facing multiple crises (economic, pandemic, energy crisis, political and security crises) becomes necessary to determine the implications of fiscal changes on the economy’s evolution. This paper aimed to assess the link between taxation and economic growth in the European Union Member States, considering panel data for the period 2000-2021 to identify taxation’s specific implications on economic growth. The methodological endeavour encompassed both qualitative and quantitative research approaches. The qualitative analysis of the study involved a bibliometric analysis of the existing literature and visual mapping of the bibliographic data employed to highlight the differences between the values of the variables recorded in the EU countries. The quantitative research methodology assumed the empirical analysis through a panel data regression with fixed and random effects to identify the reaction of the growth rate of the gross domestic product to changes in direct and indirect taxes. Our results indicate a relationship between taxation and economic growth, depending on the tax type. We have identified a direct relationship in the case of taxes on the income or profits of corporations, including holding gains and value-added taxes and an indirect relationship in the case of taxes on individual or household income including holding gains and other taxes on production. In addition, the impact of indirect taxes is more significant. These specific relationships influence the change in fiscal policies in response to economic shocks.
Effect of Cash, Receivables, and Inventory Turnover on Net Profit Margin (NPM) in Food & Beverage Subsector Manufacturing Companies
Authors: Sunaryo Deni , Lestari Etty Puji
Published: May 2023

This study focused on the influence of cash turnover, receivables turnover, and inventory turnover against the Net Profit Margin (NPM), showing the inequality of the results of previous studies. Therefore, this research investigates whether that inequality is associated with cash turnover, receivables turnover, and supply turnover against NPM, which becomes the focus of this study. The research used the data obtained from food and beverage manufacturing subsectors in the Southeast Asian Stock Exchange between 2012 and 2018. This study applied purposive sampling of 11 companies that provided a complete financial report, acquiring 77 samples. The statistical analyses used were multiple linear regression, partial testing, and simultaneous testing. The results of this study indicated that cash turnover and receivables turnover had no significant influence on the NPM, while the supply turnover had a significant influence on NPM. The results of the simulta-neous study of cash turnover, the turnover of receivables, and inventory turnover have a signif-icant rate of 0.010 < 0.05. It can be concluded that cash turnover, turnover receivables, and inventory rotation significantly influence the NPM.
Ethical Issues of Artificial Intelligence & Assisted Reproductive Technologies
Authors:   University of Malta, Malta, Zammit Raymond
Published: May 2023

The downward trend in fertility rates has not surprisingly led to an increase in assisted reproduction techniques (ART), and assisted reproduction today is characterised by high-tech, high-end investment and international fertility companies, with the global fertility services market expected to grow beyond US$25 billion by 2026. Much has happened since the birth of the first test tube baby in 1978, including personalised ovarian stimulation, extended embryonic culture, intra cytoplasmic sperm injection (ICSI), pre-implantation genetic diagnosis, embryo selection (leading to elective single embryo transfer) and oocyte vitrification. Nevertheless, the success rate of IVF currently stands at around 30%, even though this depends heavily on a number of factors, such as age and changes in the physical and psychosocial environments. Many women, therefore, have to go through multiple rounds of IVF such that the process can be time-consuming, and challenges patients both financially and emotionally. Research is thus increasingly focused on how to improve treatments and outcomes, and rapid advancements in Artificial Intelligence look promising and are increasingly being utilised in fertility clinics around the world.
Staging Lives in Latin American Theater: Bodies, Objects, Archives
Authors: Brownell Pamela
Published: May 2023

Hernández, Paola. Staging Lives in Latin American Theater: Bodies, Objects, Archives. Evanston, Northwestern University Press, 2021, 232 pp.  ISBN: 9780810143364 (tapa blanda) / 9780810143371 (tapa dura) / 9780810143388 (eBook).
El auge que las prácticas documentales han tenido en el ámbito de la creación escénica en las últimas dos décadas se ha visto acompañado por un creciente interés crítico dedicado al estudio de los nuevos modos en los que el teatro busca acercarse a lo real.
Recibido: 20 de junio 2022
Aceptado: 19 de agosto 2022
Luisa Josefina Hernández (1928-2023): lances y paradojas de una dramaturga
Authors: García Óscar Armando
Published: May 2023

legado de Luisa Josefina Hernández a la cultura mexicana es inmenso. Escritora perteneciente a la generación del Medio Siglo, se destacó en cada una de sus incursiones creativas: la narrativa, la dramaturgia y la docencia. Inquieta y constante, su presencia fue fulgurante desde sus primeros pasos en la Facultad de Filosofía y Letras de la UNAM. Sus congéneres fueron notables figuras —como Emilio Carballido, Jorge Ibargüengoitia y Sergio Magaña— quienes se convirtieron muy pronto en jóvenes talentos de la escena mexicana bajo la tutoría magisterial de Rodolfo Usigli y Celestino Gorostiza.
A rare case of inherited disorder with atypical imaging findings – A case report
Authors: Kalekar Tushar , Kumar Sai Pavan
Published: May 2023

Gaucher’s disease (GD) is one of the most commonly known which is a progressive, rare hereditary disease, with an autosomal recessive inheritance pattern. It produces a deficiency in the activity of the enzyme beta-glucosidase provoking an accumulation of glucosylceramide in the lysosomes of different cells causing cytopenias, hepatosplenomegaly, changes in the central nervous system, and skeletal manifestations. The viscera most commonly involved with accumulation of Gaucher cells is the liver and spleen. Current recommendation for evaluating and monitoring visceral involvement is volumetric magnetic resonance imaging (preferred due to lack of ionizing radiation) or computed tomography every 12–24 months. Here, we report a case of GD presented with abdominal distension since past 3 months, decreased appetite since past 1 month, and breathlessness since past 1 month.
CARPAL TUNNEL SYNDROME: SURGICAL TREATMENT OPTIONS
Authors:   Grodno State Medical University, Grodno, Belarus, Brytsko A. A. , Shelesnaya M. I. ,   Grodno State Medical University, Grodno, Belarus
Published: May 2023

Carpal tunnel syndrome is a hand disease which requires a multidisciplinary treatment approach. Conservative methods are effective in early stages of the disease. The article provides an analysis of modern literature on the possibilities of carpal tunnel release.
EVALUATION OF THE RESULTS OF CYTOLOGICAL EXAMINATION IN WOMEN OF THE ALDAN DISTRICT OF THE REPUBLIC SAKHA (YAKUTIA)
Authors: Кириллина М.П. , Софронова С.И. , Сидорова О.Г. , Николаев В.Н. , Гольдерова А.С.
Published: May 2023

Для оценки частоты встречаемости патологии шейки матки по данным цитологии и изучения их взаимосвязи с выявлением вируса папилломы человека (ВПЧ) проведен анализ цитологического исследования цервикальных мазков методом жидкостной цитологии и тестированием на вирус папилломы человека у 92 женщин Алданского района Республики Саха (Якутия). Отмечено преобладание в образцах NILM по сравнению с интраэпителиальными поражениями шейки матки. Плоскоклеточные интраэпителиальные поражения низкой степени (LSIL) были выявлены в 15 случаях и составили 62,5% от общего числа всех дисплазий. 7 женщин имели поражения высокой степени (HSIL) и составил 29,2% от всех дисплазий. По 1 (2,9%) случаю была диагностирована атипия неясного генеза (ASCUS) и атипичные клетки плоского эпителия, не позволяющие исключить HSIL (ASC-H). При сопоставлении возрастных групп у женщин до 45 лет LSIL встречалась в 1,5 раза чаще, чем у женщин в возрасте 45 лет и выше, а HSIL – в 1,3 раза. Заключение ASCUS и ASC-H было диагностировано в возрасте до 45 лет по 1 случаю (4,1% соответственно). Среди ВПЧ-позитивных тестов в преобладающем количестве наиболее часто отмечены ВПЧ 6 и 68 типов. Показано, что инфицированность вирусом папилломы человека больше в группе молодых женщин до 45 лет и несколько снижается после 45 лет.

The analysis of cytological examination was conducted by the liquid-based cytology and human papillomavirus test among 92 women living in Aldan District of the Republic of Sakha (Yakutia). It helps to study the relation between of the incidence of cervical pathology according to cytology data and the detection of human papillomavirus (HPV). The predominance of NILM in the samples compared with intraepithelial lesions of the cervix was noted. Low-grade squamous intraepithelial lesions (LSIL) were detected in 15 cases and accounted for 62.5% of the total number of all dysplasias. 7 women had high-grade lesions (HSIL) and accounted for 29.2% of all dysplasias. Atypia of undetermined significance (ASCUS) and Atypical Squamous Cells cannot exclude HSIL (ASC-H) were diagnosed in 1 (2.9%) case. When comparing age groups, LSIL was 1.5 times more common in women under 45 than in women aged 45 and older, and HSIL was 1.3 times more common. ASCUS and ASC-H were diagnosed at the age of 45 in 1 case (4.1%, resp). HPV of 6 and 68 types are the most common in the vast number of HPV-positive tests. It has been shown that human papillomavirus infection is higher in the group of young women under 45 years of age and decreases somewhat after 45 years.
ALGORITHM FOR PREDICTING AND DIAGNOSING THE DEVELOPMENT OF MYOCARDIAL INFARCTION
Authors: Гайрабекова Т.И. , Гайрабекова Ф.Р. , Гараев М.Х.
Published: May 2023

Для прогнозирования, предотвращения и эффективного лечения инфаркта и малых повреждений миокарда очень важным является своевременная диагностика их развития и в этом действенную помощь оказывают современные технологии. В работе представлен алгоритм, позволяющий прогнозировать и диагностировать развитие малых повреждений и инфаркта миокарда в основе которого лежат линейные уравнения, полученные на основе регрессионного анализа показателей уровня содержания в сыворотке крови пациентов тропонина, миоглобина и креатинфосфокиназы-МВ.

For the prediction, prevention and effective treatment of infarction and minor myocardial injuries, it is very important to diagnose their development in a timely manner, and modern technologies provide effective assistance in this. The paper presents an algorithm that allows predicting and diagnosing the development of minor injuries and myocardial infarction, which is based on linear equations obtained on the basis of regression analysis of the levels of troponin, myoglobin, and creatine phosphokinase-MB in the blood serum of patients.
Long Range Electron Transport Rates Depend on Wire Dimensions in Cytochrome Nanowires
Authors: Kulke Martin , Olson Dayna , Huang Jingcheng , Kramer David , Vermaas Josh
Published: May 2023

The ability to redirect electron transport to new reactions in living systems opens possibilities to store energy, generate new products, or probe physiological processes. Recent work by Huang et al. showed that 3D crystals of small tetraheme cytochromes (STC) could transport electrons over nanoscopic to mesoscopic distances by an electron hopping mechanism. Such protein-based structures with multiple localized electron carriers are promising materials for nanowires. A potential barrier to protein nanowire adoption for handling long-range electron transport is that fluctuations at room temperature may distort the nanostructure, hindering efficient electron transport. These fluctuations at the nano- and mesoscopic scales are quantified using classical molecular dynamics simulations for a small fragment of a STC nanowire and measure the effective distance distribution between electron carriers. From distance distributions, we develop a graph network representation for electron transport along nanowires with varying dimensions, and through stochastic methods determine the maximum electron flow that can be driven through these STC wires. Longer nanowires were capable of carrying fewer electrons than shorter nanowires with the same diameter, as long electron transfer distances that occasionally arise reduce the efficiency for electron transport. Thicker nanowires permit more alternative transport pathways, increasing electron transport beyond the increase in cross-section. Thus, this model implies that the design of protein-based nanowires that depend on electron hopping between charge carriers must consider control of the inherent protein flexibility, as more flexible protein-protein interfaces impose a limit on the required minimum diameter to carry currents commensurate with conventional electronics.
Leveraging Infrared Spectroscopy for Automated Structure Elucidation
Authors: Alberts Marvin , Laino Teodoro , Vaucher Alain C.
Published: May 2023

The application of machine learning models in chemistry has made remarkable strides in recent years. While the field of analytical chemistry has also received considerable interest from machine learning practitioners, very few models have been adopted into everyday use. Among the analytical instruments available to chemists, Infrared (IR) spectroscopy is one of the cheapest, easiest and most accessible. So far the use of IR has been limited to the identification of a select few functional groups with well-known vibrational frequencies with the interpretation of most peaks lying outside of human capabilities. We present a novel machine learning model that enables chemists to leverage the complete information contained within an IR spectrum to directly predict the molecular structure. To achieve this, we developed a transformer model trained on IR spectra that predicts the molecular structure as a SMILES string. To cover a vast portion of chemical space, we generated a training set of 634,585 simulated IR spectra using molecular dynamics. Our approach achieved a top-1 accuracy of 45.33% and a top-10 accuracy of 78.5% on a test set sampled from PubChem with a heavy atom count ranging from 6 to 13. The model is useful also in cases where an incorrect structure is predicted, as it is capable of predicting the correct scaffold in 77.01% of cases as the top-1 prediction and in 91.54% in the top-10 predictions. In addition, the model outperforms other models solely trained to predict the functional group from the IR spectrum.
The 228 valence electron rule for onion-like inorganic fullerenes X1@Y12@Z20 of Ih and Th symmetry
Authors: Patzer A.B.C. , Chang Christian , Bauer Hans , Sülzle Detlev
Published: May 2023

Based on an analysis of the experimentally known 228e- valence electron systems AsNi12As203-, SbNi12Sb203-, SbPd12Sb203-, and SnCu12Sn2012- of Ih symmetry, the new species GeZn12Ge20, KrNi12As20, BrNi12As201-, SeNi12As202-, GeMn12Br20, SeCo12Se206+, and SeFe12Se206- have been designed according to the 228 electron rule introduced in this study for onion-like inorganic fullerenes composed of late main group and transition metal elements. Of these GeZn12Ge20, KrNi12As20, BrNi12As201-, SeNi12As202-, and GeMn12Br20 together with the known AsNi12As203- and its neutral counterpart were investigated at the DFT B3LYP/6-31G(d) level of theory. With one exception they show, in fact, two stable energetic minima of Ih and Th symmetry. Relaxing the symmetry constraints further, e.g. Y12 = {Q6,R6}, additional new neutral species of the general composition Z@Q6R6@Z20 of C5v and C2v symmetry can be formulated, i.e. Z = Se, Q = Fe, R = Mn, following this new building principle, therefore, supporting and inspiring the development of new materials of icosahedral and tetrahedral symmetry.
A Ring of Rotaxanes: Studies of a Large Paramagnetic Assembly in Solution
Authors: Winpenny Richard , Bennett Tom , Nawaz Selina , Asthana Deepak , Lockyer Selena , Whitehead George , Vitorica-Yrezabal Inigo , Timco Grigore , Burton Neil , McInnes Eric
Published: May 2023

NMR spectroscopy is the standard method for establishing chemical structure in solution but relies on the compound being diamagnetic. When a compound is paramagnetic, NMR resonances are broad-ened and structural information lost. Other methods such as diffuse light scattering can establish the size of a compound but gives little structural information. Here we report the synthesis and structural characterization of four [7]rotaxanes which form by coordinating hybrid inorganic-organic [2]rotaxanes to a central {Ni12} core. Small angle X-ray scattering supported by molecular dynamic simulations demonstrates that the large molecules are stable in solution and also provides structural information about the conformers present.
N-terminal cysteine as minimalistic handle for dual, site-selective bioconjugation: application to an anti-HER2 affibody reveals synergy of two conjugated drugs
Authors: Novak Ana , Kersaudy Florian , Berger Sylvie , Morisset-Lopez Séverine , Lefoulon François , Pifferi Carlo , Aucagne Vincent
Published: May 2023

Site-selective, dual-conjugation approaches for the incorporation of distinct payloads are key for the development of molecularly targeted biomolecules, such as antibody conjugates, endowed with better properties. Combinations of cytotoxic drugs, imaging probes, or pharmacokinetics modulators enabled for improved outcomes in both molecular imaging, and therapeutic settings. We have developed an efficacious dual-bioconjugation strategy to target the N-terminal cysteine of a chemically-synthesized, third-generation anti-HER2 affibody. Such two-step, one-purification approach can be carried out under mild conditions (without chaotropic agents, neutral pH) by means of a slight excess of commercially available N-hydroxysuccinimidyl esters and maleimido-functionalized payloads, to generate dual conjugates displaying drugs (DM1/MMAE) or probes (sulfo-Cy5/biotin) in high yield and purity. Remarkably, the double drug conjugate exhibited an exacerbated cytoxicity against HER2-expressing cell lines as compared to a combination of two monoconjugates, demonstrating a potent synergistic effect. Consistently, affibody-drug conjugates did not decrease the viability of HER2-negative cells, confirming their specificity for the target.