bluuebunny/crossref_metadata_2025 huggingface dataset:
Marathon Health Pitfalls: What Every Runner Needs to Know
Authors: Gondko Daniel , Dębiec Patrycja , Roman Jakub , Pietrzak Nikodem
Published: June 2024

Introduction and Purpose: Long-distance running, especially marathons, tests human endurance and physical limits. While the benefits of marathon running are well-documented, the associated health risks often go unnoticed. This review aims to synthesize current knowledge on the health risks and complications faced by marathon runners, providing crucial insights for both amateur and professional athletes.State of Knowledge: Marathon running imposes significant stress on the cardiovascular system, musculoskeletal structure, and metabolic processes. Issues such as acute myocardial injury, overhydration leading to hyponatremia, and musculoskeletal injuries are prevalent. The review also examines less common but severe risks like rhabdomyolysis and marathon-related cardiac arrests. Despite the robust fitness levels of runners, these health risks remain a serious concern, necessitating preventive strategies and proper health monitoring.Summary: Marathon runners must be aware of the potential health risks associated with prolonged endurance activities. Precautionary measures, including tailored training programs, dietary adjustments, and regular medical check-ups, are essential to mitigate these risks. Additionally, further research is required to develop more effective interventions and guidelines that can safeguard the health of marathon participants. This review underscores the need for a balanced approach that respects the physiological demands of marathon running while ensuring the health and safety of the runners.
AI and Lyme Disease: Pioneering Advances in Diagnostic Accuracy
Authors: Dębiec Patrycja , Roman Jakub , Gondko Daniel , Pietrzak Nikodem
Published: June 2024

Introduction and Purpose: Accurate diagnosis of Lyme disease remains challenging due to its varied manifestations and the limitations of current diagnostic tests. This review examines the emerging role of artificial intelligence (AI) in enhancing the diagnostic accuracy for Lyme disease, aiming to understand how these technologies can be integrated into clinical practice.State of Knowledge: AI and machine learning techniques are increasingly applied to improve diagnostic processes. In Lyme disease, AI models have been developed to identify patterns in clinical data, enhancing early detection and accuracy. Studies have focused on using AI to interpret complex serological results and clinical symptoms more effectively than traditional methods. Additionally, AI has been utilized to analyze geographical and epidemiological data to predict Lyme disease risk areas, aiding in preventive strategies.Summary: AI holds significant promise in transforming Lyme disease diagnostics by increasing the speed and accuracy of detection. These technologies not only help in overcoming the limitations of current serological testing but also provide a framework for predictive analytics in epidemiology. As AI models continue to evolve, their integration into healthcare systems requires careful consideration of ethical implications and validation on broader scales. Future research should focus on refining AI algorithms, improving data inclusivity, and enhancing interoperability with existing medical systems to fully realize AI's potential in battling Lyme disease.
Eating disorders in pediatric population, analysis of some of the most common risk factors
Authors: Czeczotka Magdalena , Skorupska Marta , Popławska Natalia Aleksandra , Śliz Justyna , Woźniak Krzysztof
Published: June 2024

Introduction:
This article reviews a number of studies that have sought to determine what are risk factors that may cause eating disorders in the pediatric population, taking into account the age and gender of the subjects. This study focuses on issues related to purging, bulimic behaviors, and psychological orthorexia and what impact the most common risk factors for these behaviors have in the pediatric population.
 
Aim of study:
The aim of the study is to present a comprehensive review of some of the most common risk factors predisposing to the development of eating disorders in the pediatric population, and how these factors have a direct impact on each other and are intertwined, by using available knowledge, paying particular attention to a new potential risk factor - social media.
 
Materials and methods:
Materials used in this study were found in the PubMed database, using the following keywords: ,,Social media”, ,,Mass media”, ,,Peers”, ,,Family”, ,,Orthorexia nervosa”, ,,Social media”, ,,Children”, ,,Adolescence”.
 
Conclusion:
Eating disorders are a growing problem. Our research focuses on potential risk factors, with the greatest emphasis on a relatively new risk factor: social media and screen time, and how these two factors influence young minds, what impact they have on the eating habits of children and adolescents, and what can be done to prevent eating disorders in the pediatric population.
Intraductal Papillary Mucinous Neoplasms (IPMN): Diagnosis, Classification, and Risk Assessment - A Review of Current Medical Knowledge
Authors: Otręba Karina , Cieszkowska Joanna , Czupryńska Karolina , Daniel Piotr , Leśkiewicz Michał , Składanek Justyna
Published: June 2024

Introduction
In recent years, the widespread utilisation of advanced imaging modalities has led to a surge in the detection rate of pancreatic cystic lesions, particularly intraductal papillary mucinous neoplasms (IPMN). Consequently, this review aims to provide a comprehensive examination of IPMN, focusing on elucidating its intricate facets including definition, epidemiology, pathogenesis, classification, imaging modalities for diagnosis, analysis of pancreatic cyst fluid, evaluation of malignant potential, and identification of pertinent features.
Brief Overview of Current Knowledge:
IPMN represents a diagnostic conundrum owing to its variable biological behaviour encompassing both benign and malignant spectra, necessitating meticulous evaluation and risk stratification. Various imaging techniques such as MRI, CT, EUS and abdominal ultrasonography serve pivotal roles in the diagnostic algorithm and risk assessment of IPMN. Additionally, the analysis of pancreatic cyst fluid, incorporating biomarkers and the string sign test, assumes a critical role in discerning mucinous from non-mucinous cysts and gauging malignant potential. Discriminating high-risk stigmata and worrisome features serve as a compass for clinical decision-making regarding the imperative of surgical intervention versus vigilant surveillance.
Summary
Despite persistent challenges, the ongoing evolution of diagnostic modalities and risk assessment methodologies augur well for refining therapeutic strategies and enhancing clinical outcomes in managing IPMN. This review underscores the imperative of sustained research endeavours in the realm of pancreatic oncology to enrich our comprehension of IPMN pathophysiology and to optimise clinical care paradigms.
Jugando con fuego en un polvorín. La izquierda haitiana en el proceso de la consolidación y el declive de la izquierda latinoamericana (1991-2021)
Authors: Belan Alvarado César Augusto
Published: June 2024

El presente artículo busca hacer un recuento del desarrollo, evolución y disgregación de las agrupaciones políticas de izquierda en Haití, desde la transición democrática hasta el presente, en el marco de la historia política haitiana reciente. Se examinará, asimismo, la relación de las políticas planteadas y ejecutadas por estos movimientos y la relación de estas con los objetivos de los organismos de la izquierda internacional, en especial el Foro de Sao Paulo (FSP) y los entes patrocinados por el chavismo, como el ALBA y Petrocaribe. Buscaremos responder cuál fue la actuación de la izquierda haitiana, y las relaciones que ésta tuvo con la izquierda latinoamericana, en la crisis que vive Haití desde 2018 hasta la actualidad y que cobró la vida de su joven mandatario Jovenel Moïse, dejando al país en una situación anárquica.
Una historia de dos izquierdas. El MIR y el MAS entre el origen y el colapso de la «democracia pactada» boliviana (1985-2006)/
Authors: Sánchez Martínez César Félix
Published: June 2024

En este artículo se estudia la aparición, auge y colapso de la inédita experiencia de democracia liberal partitocrática en Bolivia (1985-2006), a través de la trayectoria de dos movimientos autoidentificados como izquierdistas, el Movimiento de Izquierda Revolucionaria (1971), de Jaime Paz Zamora, última y más grande manifestación de la «izquierda patricia» boliviana, y el Movimiento al Socialismo (1997), de Evo Morales, vehículo político de la renacida oposición sindical rural al sistema vigente. También se exploran las causas de su colapso; a saber: el crecimiento de las expectativas y el malestar de los sectores urbanos; la reactivación de la tradición sindical militante, en una versión más dinámica y mejor organizada, y, en el plano de la cultura política, la difusión y generalización del katarismo y sus variaciones indianistas.
Érase una vez en Euskadi y Belfast: la violencia política desde la perspectiva de la infancia
Authors: Madueño Álvarez Miguel
Published: June 2024

En este artículo se explora, a través de las películas Érase una vez en Euskadi (2021) y Belfast (2021), la perspectiva de la violencia política desde la visión de la infancia. Para ello se traza un análisis comparativo entre ambos largometrajes abordando las principales diferencias y semejanzas entre los conflictos que se vivieron en el Ulster y en el País Vasco; en el tratamiento de la violencia política a través de los personajes principales de ambas cintas, contextualizándolo con el espacio geográfico y temporal; y abordando las problemáticas del cine en los enfoques del terrorismo.
Funções Executivas, Traços de Psicopatia e Comportamento Sexual em Adolescentes Privados de Liberdade em Rondônia
Authors: Corrêa Pedro Vasconcelos , De Almeida Rosa Maria Martins
Published: June 2024

Foram avaliadas as funções executivas, traços de psicopatia, idades da primeira relação sexual e trabalho de adolescentes em conflito com a lei. As hipóteses foram que haveria diferenças entre primários e reiterantes e o papel preditor destas variáveis para o ato. O objetivo geral foi avaliar essas funções, comparar intragrupo, identificar associações e predições para a infração. Foram avaliados 109 adolescentes institucionalizados por atos graves, sendo a média de idade de 16,5 anos. Instrumentos utilizados: Wisconsin de Classificação de Cartas, a Escala Hare Psychopathy Checklist-Revised e protocolo neuropsicológico. A análise de variância diferenciou os grupos em oito variáveis, sendo que nos reiterantes houve maiores traços de psicopatia e idade da primeira infração. A idade da primeira relação sexual não diferenciou os grupos, caracterizando-os como precoce exposição. E, as funções executivas explicaram 12,1% no desfecho infração. Houve associações com a história de vida em contexto de adversidades, indicando que as funções executivas em desenvolvimento podem não protegê-los de influências negativas adversas. Realidade que acentua o papel do desenvolvimento neurobiológico nas avaliações, acompanhamentos e intervenções em situação de institucionalização de privação de liberdade socioeducativa de adolescentes por atos com grave uso de violência.
Examining speech-language pathology research relating to people with traumatic brain injury in China: a scoping review
Authors: Wei Guanyu , Riccardi Jessica Salley
Published: June 2024

Background/Aims

Although there are many researchers reviewing the existing evidence related to traumatic brain injury from speech-language pathologists' perspectives, there have been no attempts to review the existing research evidence in Standard Chinese to the best of the authors' knowledge. The purpose of this scoping review was to identify and synthesise the existing research evidence available in China for therapy related to individuals with traumatic brain injury within the speech-language pathologists' scope of practice.

Methods

This scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. The literature search was conducted using databases that included articles in the Standard Chinese language. In collaboration with three therapists working in China, the data was extracted and translated into English.

Results

Eight research articles met the inclusion and exclusion criteria of this review. Six studies were randomised control trials, and two studies were cohort studies. These eight studies focused on collaboration, counselling and treatment. All studies addressed cognition and two also addressed language.

Conclusions

Evidence showed that treatment focusing on cognitive and language skills provided by speech-language pathologists can improve the lives of people with a traumatic brain injury living in China. More research is warranted to better understand traumatic brain injury and treatment efficacy in China.

Implications for practice

Clinicians, especially those who work with individuals who affiliate themselves with the Chinese culture, can consider the current research evidence discussed in this article when working with clients with traumatic brain injury. Additionally, for researchers, future research efforts can prioritise addressing the identified gaps outlined in this study.
Social prescribing: how it can help people with long-term health conditions
Authors: Hong Chia Swee
Published: June 2024

Chia Swee Hong discusses social prescribing and how allied health professionals can help primary care professionals.
Clear cell sarcoma metastasizing to the pancreas
Authors: Chisthi Meer M
Published: June 2024

In this editorial based on a case report, we delve into a seldom-seen occurrence of clear cell sarcoma featuring pancreatic metastasis in a 47-year-old male patient. Recognized for its typical tendency to metastasize to the lungs, bones, and brain, clear cell sarcoma rarely extends its reach to the pancreas. Despite the initial absence of discernible abnormalities during the patient's physical examination, the manifestation of abdominal pain prompted further investigation. Subsequent abdominal computed tomography brought to light the presence of a pancreatic tumor, culminating in the definitive diagnosis of clear cell sarcoma with pancreatic metastasis. The successful management of this atypical presentation involved a series of surgical interventions, including distal pancreatectomy and splenectomy. This report not only sheds light on the infrequent manifestation of clear cell sarcoma within the pancreas but also underscores the pivotal role of vigilant postoperative follow-up in addressing this rare sarcoma. The emphasis on postoperative care serves as a crucial aspect of the broader narrative, acknowledging the need for ongoing monitoring and management to ensure a comprehensive and successful treatment trajectory for patients with this unique presentation of clear cell sarcoma.
Early detection of pancreatic cancer
Authors: Morera-Ocon Francisco J
Published: June 2024

The diagnosis of pancreatic cancer associates an appalling significance. Detection of preinvasive stage of pancreatic cancer will ameliorate the survival of this deadly disease. Premalignant lesions such as Intraductal Papillary Mucinous Neoplasms or Mucinous Cystic Neoplasms of the pancreas are detectable on imaging exams and this permits their management prior their invasive development. Pancreatic intraepithelial neoplasms (PanIN) are the most frequent precursors of pancreatic adenocarcinoma (PDAC), and its particular type PanIN high-grade represents the malignant non-invasive form of PDAC. Unfortunately, PanINs are not detectable on radiologic exams. Nevertheless, they can associate indirect imaging signs which would rise the diagnostic suspicion. When this suspicion is established, the patient will be enrolled in a follow-up strategy that includes performing of blood test and serial imaging test such as computed tomography or magnetic resonance imaging, which will cost in the best-case scenario a burden of healthcare systems, and potential mortality in the worst-case scenario when the patient underwent resection surgery, worthless when there is no moderate or high grade dysplasia in the final histopathology. This issue will be avoid having at its disposal a diagnostic technique capable of detecting high-grade PanIN lesions, such is the cytology of pancreatic juice obtained by nasopancreatic intubation. Herein, we review the possibility of detection of early malignant lesions before they become invasive PADC.
Fat or fillers: The dilemma in eyelid surgery
Authors: Miotti Giovanni , De Marco Luca , Quaglia Davide , Grando Martina , Salati Carlo , Spadea Leopoldo , Gagliano Caterina , Musa Mutali , Surico Pier Luigi , Parodi Pier Camillo , Zeppieri Marco
Published: June 2024

The aging of the periocular region has always aroused great interest. A fresh, young, and attractive sight determined an ever-greater attention to surgical and non-surgical techniques to obtain this result. In particular, the change in the concept of a young look, considered then “full”, led to the increasing use of surgical (fat grafting) or medical (hyaluronic acid) filling techniques. Eyelid rejuvenation became increasingly popular in the field of cosmetic treatments, with a focus on achieving a youthful and refreshed appearance. Among the various techniques available, the choice between using fat grafting or fillers presented a clinical dilemma. In particular, what surgery considered of fundamental importance was a long-lasting result over time. On the other hand, aesthetic medicine considered it fundamental not to have to resort to invasive treatments. But what was the reality? Was there one path better than the other, and above all, was there a better path for patients? The minireview aims to explore the physiopathology, diagnosis, treatment options, prognosis, and future studies regarding this dilemma. We analyzed the literature produced in the last 20 years comparing the two techniques. Current literature reveals advancements in biomaterials, stem cell research and tissue engineering held promise for further enhancing the field of eyelid rejuvenation. The choice between fat grafting and fillers in eyelid cosmetic treatments presented a clinical dilemma. Understanding physiopathology, accurately diagnosing eyelid aging, exploring treatment options, assessing prognosis, and conducting future studies were essential for providing optimal care to patients seeking eyelid rejuvenation.
Outpatient insulin use in type 2 diabetes mellitus and acute respiratory distress syndrome outcomes: A retrospective cohort study
Authors: Khattar Georges , Asmar Samer , Aoun Laurence , Saliba Fares , Almardini Shaza , Abu Baker Saif , Hong Catherine , El Chamieh Carolla , Haddadin Fadi , Habib Toni , Mourad Omar , Morcos Zeina , Arafa Fatema , Mina Jonathan , El Gharib Khalil , Aldalahmeh Mohammad , Khan Salman , Bou Sanayeh Elie
Published: June 2024

BACKGROUND

The impact of type 2 diabetes mellitus (T2DM) on acute respiratory distress syndrome (ARDS) is debatable. T2DM was suspected to reduce the risk and complications of ARDS. However, during coronavirus disease 2019 (COVID-19), T2DM predisposed patients to ARDS, especially those who were on insulin at home.

AIM

To evaluate the impact of outpatient insulin use in T2DM patients on non-COVID-19 ARDS outcomes.

METHODS

We conducted a retrospective cohort analysis using the Nationwide Inpatient Sample database. Adult patients diagnosed with ARDS were stratified into insulin-dependent diabetes mellitus (DM) (IDDM) and non-insulin-dependent DM (NIDDM) groups. After applying exclusion criteria and matching over 20 variables, we compared cohorts for mortality, duration of mechanical ventilation, incidence of acute kidney injury (AKI), length of stay (LOS), hospitalization costs, and other clinical outcomes.

RESULTS

Following 1:1 propensity score matching, the analysis included 274 patients in each group. Notably, no statistically significant differences emerged between the IDDM and NIDDM groups in terms of mortality rates (32.8% vs 31.0%, P = 0.520), median hospital LOS (10 d, P = 0.537), requirement for mechanical ventilation, incidence rates of sepsis, pneumonia or AKI, median total hospitalization costs, or patient disposition upon discharge.

CONCLUSION

Compared to alternative anti-diabetic medications, outpatient insulin treatment does not appear to exert an independent influence on in-hospital morbidity or mortality in diabetic patients with non-COVID-19 ARDS.
Dosimetric risk factors for radiation esophagitis in patients with breast cancer following regional nodal radiation
Authors: Ji Mei-Chen , Li Zhi-Jia , Li Ke , Wang Yun-Xiao , Yang Bo , Lv Lin-Lin , Su Ying , Zhang Zhi-Wei , Huo Zhong-Chao , Qi Qing , Lu Yong-Chang , Cui Zhi-Qiang , Liu Yan-Bao
Published: June 2024

BACKGROUND

Radiation esophagitis (RE) is one of the most common clinical symptoms of regi-onal lymph node radiotherapy for breast cancer. However, there are fewer studies focusing on RE caused by hypofractionated radiotherapy (HFRT).

AIM

To analyze the clinical and dosimetric factors that contribute to the development of RE in patients with breast cancer treated with HFRT of regional lymph nodes.

METHODS

Between January and December 2022, we retrospectively analysed 64 patients with breast cancer who met our inclusion criteria underwent regional nodal intensity-modulated radiotherapy at a radiotherapy dose of 43.5 Gy/15F.

RESULTS

Of the 64 patients in this study, 24 (37.5%) did not develop RE, 29 (45.3%) developed grade 1 RE (G1RE), 11 (17.2%) developed grade 2 RE (G2RE), and none developed grade 3 RE or higher. Our univariable logistic regression analysis found G2RE to be significantly correlated with the maximum dose, mean dose, relative volume 20-40, and absolute volume (AV) 20-40. Our stepwise linear regression analyses found AV30 and AV35 to be significantly associated with G2RE (P < 0.001). The optimal threshold for AV30 was 2.39 mL [area under the curve (AUC): 0.996; sensitivity: 90.9%; specificity: 91.1%]. The optimal threshold for AV35 was 0.71 mL (AUC: 0.932; sensitivity: 90.9%; specificity: 83.9%).

CONCLUSION

AV30 and AV35 were significantly associated with G2RE. The thresholds for AV30 and AV35 should be limited to 2.39 mL and 0.71 mL, respectively.
Effect of Luhong formula on the cardiac rehabilitation of patients with chronic heart failure
Authors: Xu Ji-Jie , Dai Jian , Xie Qi-Hai , Du Pei-Chao , Li Cha , Zhou Hua
Published: June 2024

BACKGROUND

Current treatments for chronic heart failure (CHF) are therapeutically ineffective. The optimization of treatments for this disease needs to be explored and analyzed.

AIM

To analyze the effect of using Luhong Formula in the cardiac rehabilitation of patients with CHF and its influence on cardiopulmonary function (CPF) and prognosis.

METHODS

In total, 160 patients with CHF admitted between June 2022 and June 2023 were selected, including 75 receiving perindopril (control group) and 85 receiving Luhong Formula (research group). We conducted comparative analyses on the curative effects of traditional Chinese medicine (TCM) syndromes and cardiac function, CPF [oxygen consumption at the anaerobic threshold (VO2 AT) and at peak exercise (peak VO2)], echocardiographic indexes [left atrial volume index (LAVI), left ventricular muscle mass index (LVMI), left ventricular ejection fraction (LVEF)], and prognosis [major adverse cardiovascular events (MACEs) at 6 months follow-up].

RESULTS

The research group showed markedly higher curative effects of TCM syndromes and cardiac function than the control group. In addition, post-treatment VO2 AT, peak VO2, LVMI and LVEF in the research group were significantly higher, whereas LAVI was significantly lower, than those of the control group. Furthermore, fewer patients in the research group developed MACEs at the 6-month follow-up.

CONCLUSION

Luhong Formula is more therapeutically effective than perindopril for the cardiac rehabilitation of patients with CHF, specifically in enhancing CPF and prognosis.
Diagnostic efficacy of virtual organ computer-assisted analysis in measuring the volume ratio of subchorionic hematoma with serum progesterone
Authors: Shen Lin-Ling , Shi Jing , Ding Chang-Wei , Dai Gao-Le , Ma Qi
Published: June 2024

BACKGROUND

Subchorionic hematoma (SCH) is a common complication in early pregnancy characterized by the accumulation of blood between the uterine wall and the chorionic membrane. SCH can lead to adverse pregnancy outcomes such as miscarriage, preterm birth, and other complications. Early detection and accurate assessment of SCH are crucial for appropriate management and improved pregnancy outcomes.

AIM

To evaluate the diagnostic efficacy of virtual organ computer-assisted analysis (VOCAL) in measuring the volume ratio of SCH to gestational sac (GS) combined with serum progesterone on early pregnancy outcomes in patients with SCH.

METHODS

A total of 153 patients with SCH in their first-trimester pregnancies between 6 and 11 wk were enrolled. All patients were followed up until a gestational age of 20 wk. The parameters of transvaginal two-dimensional ultrasound, including the circumference of SCH (Cs), surface area of SCH (Ss), circumference of GS (Cg), and surface area of GS (Sg), and the parameters of VOCAL with transvaginal three-dimensional ultrasound, including the three-dimensional volume of SCH (3DVs) and GS (3DVg), were recorded. The size of the SCH and its ratio to the GS size (Cs/Cg, Ss/Sg, 3DVs/3DVg) were recorded and compared.

RESULTS

Compared with those in the normal pregnancy group, the adverse pregnancy group had higher Cs/Cg, Ss/Sg, and 3DVs/3DVg ratios (P < 0.05). When 3DVs/3DVg was 0.220, the highest predictive performance predicted adverse pregnancy outcomes, resulting in an AUC of 0.767, and the sensitivity, specificity were 70.2%, 75% respectively. VOCAL measuring 3DVs/3DVg combined with serum progesterone gave a diagnostic AUC of 0.824 for early pregnancy outcome in SCH patients, with a high sensitivity of 82.1% and a specificity of 72.1%, which showed a significant difference between AUC.

CONCLUSION

VOCAL-measured 3DVs/3DVg effectively quantifies the severity of SCH, while combined serum progesterone better predicts adverse pregnancy outcomes.
Effects of psychological nursing in Parkinson's related depression patients undergoing functional magnetic resonance imaging: A randomized controlled trial
Authors: Zhang Xiao-Xia , Zhang Xiao-Hui , Dong Yan-Chao
Published: June 2024

BACKGROUND

Patients with Parkinson’s disease (PD) often experience depression, and some may require magnetic resonance imaging (MRI) for diagnosis, which can lead to MRI failure due to claustrophobia.

AIM

To explore the value of psychological interventions in successfully completing functional MRI scans of the brain for PD-related depression.

METHODS

Ninety-six patients with PD were randomly divided into two groups. The control group (47 patients) received general care, and the experimental group (49 patients) received general care combined with psychological care. The Unified Parkinson's Disease Assessment Scale (UPDRS), Hamilton Depression Scale (HAMD), and Geriatric Depression Scale (GDS)-15 scores, heart rate, systolic blood pressure, and MRI-Anxiety Questionnaire (MRI-AQ) scores before and after the scan were recorded. The completion rate of magnetic resonance (MR) scanning, scanning duration, and image quality scores were recorded.

RESULTS

Before scanning, no statistically significant difference was observed between the two groups in terms of heart rate, systolic blood pressure, and UPDRS, HAMD, GDS-15, and MRI-AQ scores. After scanning, systolic blood pressure, MRI-AQ score, and scan time in the experimental group were significantly lower than those in the control group, whereas the scan completion rate and image quality score were significantly higher than those in the control group.

CONCLUSION

Psychological nursing interventions are helpful in alleviating PD-related depression and assessing MR depression scores and may be helpful in the successful completion of functional MRI scans of the patient's brain.
Percutaneous kyphoplasty in the treatment of Kümmell disease in lumbar scoliosis: A case report
Authors: Saijilafu Saijilafu , Zhou Jia-Wen , Wang Gen-Lin , Sun Ke-Hong , Xie Ji-Le
Published: June 2024

BACKGROUND

Due to mechanical imbalance in the spine, elderly scoliosis patients tend to develop vertebral fracture nonunion, i.e. , Kümmell disease, when osteoporotic vertebral compression fractures occur. However, accompanying vertebral rotational deformities make surgical procedures challenging risky. Such patients are usually compelled to undergo conservative treatment and there are very few reports on minimally invasive surgeries for them. We first-time report a patient with Kümmell disease and lumbar scoliosis treated with percutaneous kyphoplasty (PKP) under O-arm guidance.

CASE SUMMARY

An 89-year-old female was admitted to the hospital due to delayed low back pain after a fall. She was diagnosed with Kümmell disease based on physical and radiologic examinations. The patient experienced severe scoliosis and subsequently underwent O-arm-guided kyphoplasty, resulting in a significant alleviation of low back pain.

CONCLUSION

PKP has good efficacy in treating Kümmell disease. However, surgical risks are elevated in scoliosis patients with Kümmell disease due to the abnormal anatomical structure of the spine. O-arm assisted operations play a crucial role in decreasing surgical risks.
Hemolysis attributed to high dose vitamin C: Two case reports
Authors: Wang Shi-Wan , Zhang Xiao-Wei , Qu Jin-Xiu , Rao Yi-Zhong , Lu Shuai , Wang Bing , He Jia , Zhao Yuan , Rao Ben-Qiang
Published: June 2024

BACKGROUND

High-dose vitamin C treatment (HVCT) can reduce the adverse effect of chemotherapy and enhance the effect of antitumor therapy, which has been considered one of the safest alternative treatments. However, the severity of its adverse effects may have been underestimated. The most serious adverse effect is hemolysis, which may result in acute kidney injury or death. Although glucose-6-phosphate dehydrogenase (G6PD) deficiency is considered to be the main cause, the probability and pathological mechanism are not completely understood, leading to a lack of effective and standardized treatment methods.

CASE SUMMARY

Two patients with colorectal cancer developed hemolytic anemia after using 1 g/kg HVCT. In contrast to previous cases, the lowest hemoglobin level in the two cases was < 50 g/L, which was lower than previously reported. This may be because Case 1 had chronic hepatitis B for many years, which caused abnormal liver reserve function, and Case 2 had grade II bone marrow suppression. Both patients improved and were discharged after blood replacement therapy. Our cases had the most severe degree of hemolysis but the best prognosis, suggesting that our treatment may be helpful for rescue of drug-induced hemolysis. This is the first review of the literature on hemolysis caused by HVCT, and we found that all patients with G6PD deficiency developed hemolysis after HVCT.

CONCLUSION

G6PD deficiency should be considered as a contraindication to HVCT, and it is not recommended for patients with bone marrow suppression, moderate-to-severe anemia, hematopoietic abnormalities, or abnormal liver and kidney function. Early blood purification and steroid therapy may avoid acute kidney injury or death caused by HVCT-related hemolytic anemia.
Regional anesthesia in a patient with primary ciliary dyskinesia: A case report
Authors: Park Hyung Joon , Kim Ye Hwan , Yoon Young Joon , Cho Sang Yun
Published: June 2024

BACKGROUND

Primary ciliary dyskinesia (PCD) is an inherited autosomal-recessive disorder of impaired mucociliary clearance characterized by chronic respiratory diseases, otolaryngological diseases, central nervous system abnormalities, reproductive system abnormalities, and cardiac function abnormalities. General anesthesia in these patients is associated with a higher incidence of respiratory complications than in patients without the disease.

CASE SUMMARY

A 16-year-old male patient was referred to the emergency room complaining of right ankle pain due to distal tibiofibular fracture. Three years prior, he had been diagnosed with PCD. At that time, he had experienced several episodes of pneumonia, sinusitis, and chronic middle ear infections, for which he underwent surgical interventions. At the current admission, he presented with cough and sputum but no other respiratory symptoms. A chest computed tomography scan revealed centrilobular ground-glass opacities in both lower lobes and a calcified nodule in the left lower lobe. For the surgical procedure and postoperative pain management, combined spinal-epidural anesthesia was employed. The patient’s postoperative pain score was measured by the numerical rating scale (NRS). On the day of surgery, his NRS was 5 points. By the second postoperative day, the NRS score had decreased to 2–3 points. The epidural catheter was removed on the fourth day following the operation. The patient was subsequently discharged no respiratory complications.

CONCLUSION

We performed combined spinal-epidural anesthesia in a patient with PCD. The patient experienced no additional respiratory complications and was discharged with a low NRS score for pain.
Primary ovarian cancer combined with primary fallopian tube cancer: A case report
Authors: Bai Su-Ning , Wu Qi , Song Li-Yun
Published: June 2024

BACKGROUND

Low grade serous carcinoma of the ovary (LGSOC) is a rare type of epithelial ovarian cancer with a low incidence rate. The origin of ovarian cancer has always been a hot topic in gynecological oncology research, and some scholars believe that the origin of ovarian malignant tumors is the fallopian tubes. Primary fallopian tube cancer is the lowest incidence of malignant tumors in the female reproductive system. There are only a few reports in the literature, but the mortality rate is very high. But in clinical practice, fallopian tube cancer is very common, but in most cases, it is classified as ovarian cancer.

CASE SUMMARY

We report a 54 years old postmenopausal woman who was hospitalized with a lower abdominal mass and underwent surgical treatment. The final pathological confirmation was low-grade serous carcinoma of the right ovary and low-grade serous carcinoma of the left fallopian tube. No special treatment was performed after the surgery, and the patient was instructed to undergo regular follow-up without any signs of disease progression.

CONCLUSION

The prognosis of LGSOC is relatively good, over 80% of patients still experience disease recurrence.
Superficial femoral artery pseudoaneurysm at implantation site of drug eluting stent discovered due to bacteremia: A case report
Authors: Akai Takafumi , Ninomiya Shintarou , Kaneko Takanori
Published: June 2024

BACKGROUND

Drug-eluting stents (DES) are used to treat lower extremity arterial disease. During DES treatment, aneurysmal degeneration occasionally occurs, especially with fluoropolymer-based DES. However, the incidence of pseudoaneurysms after DES placement is rarely reported in the lower extremity region, although there have been several reports on pseudoaneurysm formation after DES pla-cement in the coronary artery region.

CASE SUMMARY

We report the case of a 64-year-old man who presented with fever and pain in his left hand after dialysis. Bacteremia was diagnosed by blood culture, and after admission, he developed pain on the medial side of the right thigh. A pseudoaneurysm was observed in the right superficial femoral artery (SFA) at the proximal end of a previously placed DES. The bacteremia was thought to have been caused by a pseudoaneurysm of the left superficial brachial artery, and the pseudoaneurysm of the left superficial brachial artery was removed after antibiotic treatment. The pseudoaneurysm of the right SFA rapidly expanded after admission, but the expansion rate was reduced after infection control. Seven months after the first admission, the pseudoaneurysm of the left SFA was re-moved and in situ revascularization performed using a rifampicin-soaked Dacron graft.

CONCLUSION

Although pseudoaneurysm after DES placement in the lower extremity region is rare, it must be considered in patients with bacteremia.
Laparoscopic spleen-preserving total pancreatectomy for the treatment of low-grade malignant pancreatic tumors: Two case reports and review of literature
Authors: Sun Meng-Qing , Kang Xiao-Man , He Xiao-Dong , Han Xian-Lin
Published: June 2024

BACKGROUND

Function-preserving pancreatectomy can improve the long-term quality of life of patients with benign or low-grade malignant tumors, such as intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms. However, there is limited literature on laparoscopic spleen-preserving total pancreatectomy (L-SpTP) due to technical difficulties.

CASE SUMMARY

Patient 1 was a 51-year-old male diagnosed with IPMN based on preoperative imaging, showing solid nodules in the pancreatic head and diffuse dilation of the main pancreatic duct with atrophy of the distal pancreas. We performed L-SpTP with preservation of the splenic vessels, and the postoperative pathology report revealed IPMN with invasive carcinoma. Patient 2 was a 60-year-old male with multiple cystic lesions in the pancreatic head and body. L-SpTP was performed, and intraoperatively, the splenic vein was injured and required ligation. Postoperative pathology revealed a mucinous cystic tumor of the pancreas with low-grade dysplasia. Both patients were discharged on postoperative day 7, and there were no major complications during the perioperative period.

CONCLUSION

We believe that L-SpTP is a safe and feasible treatment for low-grade malignant pancreatic tumors, but more case studies are needed to evaluate its safety, efficacy, and long-term outcomes.
Treatment of lumbar disc herniation with robot combined with unilateral biportal endoscopic technology: A case report
Authors: Liu Yan-Dong , Xu Duo-Fang , Deng Qiang , Zhang Yan-Jun , Guo Tie-Feng , Peng Ran-Dong , Li Jun-Jie
Published: June 2024

BACKGROUND

This reported procedure combines the orthopedic surgical robot with the unilateral biportal endoscopy-lumbar interbody fusion (UBE-LIF), utilizing the UBE's wide viewing field and operating space to perform minimally invasive decompressive fusion of the lesioned segment, and the orthopedic surgical robot's intelligence and precision to perform percutaneous pedicle screw placement. The advancement of this procedure lies in the superposition of advantages and offsetting disadvantages of the two new technologies, and the maximum effect of treatment is achieved with maximum minimization of invasiveness and precision under the monitoring of imaging instruments to maximize the benefit of patients, and this review reports a case of multiple-segment lumbar decompression and fusion surgery for lumbar disc herniation via robot-assisted UBE for reference.

CASE SUMMARY

A 44-year-old patient presented to our hospital. Combining various clinical data, we diagnosed the patient with lumbar disc herniation with radiculopathy, lumbar spondylolisthesis, and lumbar spinal stenosis. We developed a surgical plan of "UBE decompression + UBE-LIF + orthopedic surgery robot-assisted percutaneous pedicle screw implantation for internal fixation". The results were satisfactory.

CONCLUSION

We present an extremely rare case of multiple-segment lumbar decompression and fusion surgery for lumbar disc herniation via robot-assisted UBE and achieved good results. Therefore, the technique is worthy of clinical promotion.
Ocular rosacea without facial erythema involvement manifesting as bilateral multiple recurrent chalazions: A case report
Authors: Han Xue-Mei , Zhou Yi-Mai , Cen Lu-Sha
Published: June 2024

BACKGROUND

In addition to the non-specific symptomatology of ocular rosacea, currently, there are no reliable diagnostic tests for the disease, which may lead to its misdiagnosis. Here, we report a case of ocular rosacea presenting with multiple recurrent chalazion on both eyelids.

CASE SUMMARY

A 63-year-old female patient presented with multiple chalazion and dry eyes in both eyes, with no facial erythema. Initial management done were application of steroid eye ointment on both eyelids, hot compresses, and eyelid margin cleaning; noting that there was no relief of symptoms. Surgical excision of the chalazion was done on both eyes, however, bilateral recurrence occurred post-operatively. The pathological studies showed infiltration of a small amount of fibrous tissue with many chronic inflammatory cells. Immunohistochemistry studies were positive for LL-37. Resolution of the chalazion occurred after oral administration of doxycycline and azithromycin.

CONCLUSION

Our findings show that ophthalmologists should recognize the ocular manifestations of skin diseases.
Lateral femoral tunnel preparation and graft fixation for anterior cruciate ligament reconstruction–A discussion
Authors: Chandanani Mehak , Volpin Andrea
Published: June 2024

This article provides a discussion and commentary around the recent advances in arthroscopic anterior cruciate ligament reconstruction (ACLR), with a focus on the aspects of lateral femoral tunnel preparation and graft fixation techniques. The paper explores and comments on a recently published review by Dai et al , titled "Research progress on preparation of lateral femoral tunnel and graft fixation in ACLR", while providing insight into its relevance within the field of ACLR, and recommendations for future research.
INVERTED AND EVERTED SLOPE WALKING LEADS TO INCREASED KNEE COMPENSATION IN ANKLE FUSION COMPARED TO TOTAL ANKLE ARTHROPLASTY
Authors: Safdar N. Z. , Chapman G. , Hopwood J. , Brockett C. , Redmond A.
Published: June 2024

Ankle fusion (AF), a durable intervention for ankle arthritis, has been the management of choice but restricts mobility. Recently, total ankle replacement (TAR) has been offered to patients looking to maintain mobility. The aim was to compare the biomechanics of AF and TAR while walking on inverted and everted slopes which create a greater demand for complex foot mobility than level walking. A ten-camera motion detection setup captured trials as patients walked in both directions over a 5⁰ lateral slope with embedded force plates. Moments (Nm/Kg) across the knee and ankle were exported from Visual 3D in the sagittal and frontal plane, and data were reported as means with 95% confidence intervals. 15 patients were recruited (6 TAR, 9 AF). The median age, follow-up and BMI was 67 years, 4 years and 35.8 kg/m² in AF, and 73 years, 7 years and 28.1 kg/m² in TAR, respectively. During inverted slope walking (4 TAR, 7 AF), abduction moments across (i) the knee: TAR 0.38 (0.37–0.39) vs AF 0.37 (0.27–0.52) and (ii) the ankle: TAR 0.20 (0.13–0.27) vs AF 0.25 (0.18–0.32), and extension moments across (i) the knee: TAR 0.68 (0.38–0.97) vs AF 0.85 (0.69–1.01) and (ii) the ankle: TAR 1.46 (1.30–1.62) vs AF 1.30 (1.08–1.52). During everted walking (5 TAR, 7 AF), abduction moments across (i) the knee: TAR 0.41 (0.30–0.52) vs AF 0.46 (0.27–0.66) and (ii) the ankle: TAR 0.24 (0.11–0.38) vs AF 0.26 (0.18–0.33), and extension moments across (i) the knee: TAR 0.76 (0.54–0.99) vs AF 0.93 (0.72–1.14) and (ii) the ankle: TAR 1.39 (1.19–1.59) vs AF 1.26 (1.04–1.48). There were no differences in abduction moments during inverted or everted slope walking. However, patients with AF had increased extension moments across the knee, particularly on inverted slopes, suggesting that AF creates a greater demand for knee compensation than TAR.
FUNCTIONAL OUTCOMES OF DORSAL BRIDGE PLATING FOR LISFRANC INJURIES WITH ROUTINE METALWORK RETENTION: A MAJOR TRAUMA CENTRE EXPERIENCE
Authors: Onochie E. , Bua N. , Patel A. , Heidari N. , Vris A. , Malagelada F. , Parker L. , Jeyaseelan L.
Published: June 2024

Background

Anatomical reduction of unstable Lisfranc injuries is crucial. Evidence as to the best methods of surgical stabilization remains sparse, with small patient numbers a particular issue. Dorsal bridge plating offers rigid stability and joint preservation.

The primary aim of this study was to assess the medium-term functional outcomes for patients treated with this technique at our centre. Additionally, we review for risk factors that influence outcomes.

Methods

85 patients who underwent open reduction and dorsal bridge plate fixation of unstable Lisfranc injuries between January 2014 and January 2019 were identified. Metalwork was not routinely removed. A retrospective review of case notes was conducted. The Manchester-Oxford Foot Questionnaire summary index (MOXFQ-Index) was the primary outcome measure, collected at final follow-up, with a minimum follow-up of 24 months. The American Orthopedic Foot and Ankle Society (AOFAS) midfoot scale, complications, and all-cause re-operation rates were secondary outcome measures. Univariate and multivariate analyses were used to identify risk factors associated with poorer outcomes.

Results

Mean follow-up 40.8 months (24–72). Mean MOXFQ-Index 27.0 (SD 7.1). Mean AOFAS score 72.6 (SD 11.6). 48/85 patients had injury patterns that included an intra-articular fracture and this was associated with poorer outcomes, with worse MOXFQ and AOFAS scores (both p < 0.001). 18 patients (21%) required the removal of metalwork for either prominence or stiffness. Female patients were more likely to require metalwork removal (OR 3.89, 95% CI 1.27 to 12.0, p = 0.02). Eight patients (9%) required secondary arthrodesis.

Conclusions

This is the largest series of Lisfranc injuries treated with dorsal bridge plate fixation reported to date and the only to routinely retain metalwork. The technique is safe and effective. The presence of an intraarticular fracture is a poor prognostic indicator. Metalwork removal is more likely to be needed in female patients but routine removal may not be essential.
INTRA-ARTICULAR HAEMATOMA BLOCK VERSUS PROCEDURAL SEDATION FOR MANIPULATION OF CLOSED ANKLE FRACTURE DISLOCATIONS: AN EFFICACIOUS, RESOURCE-SPARING SOLUTION?
Authors: McFall J. , Koc T. , Morcos Z. , Sawyer M. , Welling A.
Published: June 2024

Background

Procedural sedation (PS) requires two suitably qualified clinicians and a dedicated monitored bed space. We present the results of intra-articular haematoma blocks (IAHB), using local anaesthetic, for the manipulation of closed ankle fracture dislocations and compared resource use with PS.

Methods

Patients received intra-articular ankle haematoma blocks for displaced ankle fractures requiring manipulation between October 2020 to April 2021. The technique used 10ml of 1% lignocaine injected anteromedially into the tibiotalar joint. Pain scores (VAS), time from first x-ray to reduction, and acceptability of reduction were recorded. A comparison was made by retrospective analysis of patients who had undergone PS for manipulation of an ankle fracture over the six month period March – August 2020.

Results

During the periods assessed, 25 patients received an IAHB and 28 received PS for ankle fractures requiring manipulation (mean age 57.8yr vs 55.1yr). Time from first x-ray to manipulation was 65.9 min (IAHB) vs 82.9 min (PS) (p = 0.087). In the IAHB group mean pain scores pre, during and post manipulation were 6.1, 4.7 and 2.0 respectively (‘pre’ to ‘during’ p < 0.05; ‘pre’ to ‘post’ p < 0.01). In the IAHB group, 23 (92%) had a satisfactory reduction without need of PS or general anaesthetic. In the PS group 23 (82%) had a satisfactory reduction. There was no significant difference in the number of unsatisfactory first attempt reductions between the groups. There were no cases of deep infection post operatively in either group.

Conclusion

Intra-articular haematoma block of the ankle appears to be an efficacious, safe and inexpensive means of providing analgesia for manipulation of displaced ankle fractures. Advantages of this method include avoiding the risks of procedural sedation, removing the requirement of designated clinical space and need for qualified clinicians to give sedation, and the ability to re-manipulate under the same block.