bluuebunny/crossref_metadata_2025 huggingface dataset:
An Alternative Wound Class for Orthopedic Surgery is more Strongly Associated with Risk for Postoperative Infection in Total Joint Arthroplasty than the Current Surgical Wound Classification System
Authors: Wilke Benjamin , Sessums Price , Shi Glenn , Libertin Claudia , Heckman Michael , Brushaber Danielle , Ledford Cameron
Published: October 2024

Introduction

Surgical site infections (SSI) continue to be a risk associated with surgery. The Centers for Disease Control (CDC) uses surgical wound class (SWC) to predict SSI postoperatively. Prior studies have shown that the current wound class definitions are unreliable for surgical subspecialties. Therefore, an alternative surgical wound classification (ASWC) was created to more accurately reflect risk of SSI following orthopedic procedures. The purpose of this study was to compare the two systems.

Methods

Seventy patients who developed 90-day SSI following total joint arthroplasty (TJA) were matched 1:1 to patients without postoperative SSI. The SWC was recorded from operative reports. Wounds were then retrospectively reclassified according to the ASWC based on preoperative history from the medical record. The degree of agreement and degree of association with occurrence of SSI was compared between the two systems.

Results

The proportion of agreement between the systems was poor (41.4%). The current SWC was associated with risk of SSI in both unadjusted (p=0.045) and multivariable analysis (p=0.050). Comparatively, the ASWC demonstrated a stronger association with SSI in both unadjusted (p=0.001) and multivariable analysis (p=0.001).

Conclusion

The results of this study suggest that the ASWC is more predictive for SSI following TJA than the current SWC definitions for total joint arthroplasty.
Application of Controlled Release Mechanisms in Vaccine Delivery
Authors: Xu Yuhan
Published: October 2024

Vaccines, as an essential means of preventive medicine, profoundly impact human health by stimulating an immune response to protect the body from pathogens or treat diseases. However, conventional vaccine delivery methods have limitations such as multiple injections, rapid degradation in vivo, and difficulty in targeted delivery. The development of controlled release mechanisms has overcome these challenges, optimized the immune response and improved the efficacy and safety of vaccines by precisely controlling the time, space and dose of vaccine release in vivo. This review explores the fundamentals, recent applications and future directions of controlled release mechanisms in vaccine delivery, focusing on the design and application of intelligent delivery systems such as biodegradable nanoparticles, self-healing microspheres, scaffolded vaccines and targeted vaccine systems. With the continuous progress of biotechnology and nanotechnology, controlled-release vaccines herald a new direction in vaccine design and delivery and bring efficient vaccine products to global public health.
Activación y cascada de señalización de los linfocitos B
Authors: Sánchez M.L.
Published: October 2024

Las células B expresan en su superficie inmunoglobulinas de membrana asociadas a un heterodímero, que participa en la cascada de señalización para la activación de estas células y su diferenciación en células plasmáticas productoras de anticuerpos secretados. Los reordenamientos del ADN y el corte y empalme alternativo del ARN son dos mecanismos que permiten explicar la gran diversidad de idiotipos de anticuerpos presentes en el organismo, los sitios de reconocimiento del antígeno con diferente especificidad o afinidad, así como la co-expresión de diferentes isotipos de inmunoglobulinas(IgM e IgD) sobre la membrana plasmática y la diferenciación entre inmunoglobulinas de membrana y secretadas (mIgM y sIgM). Las reacciones de fosforilación de las proteínas resultan de fundamental importancia para este proceso. En esta activación, participan también los fosfatidil-inositoles para la producción del inositol 3 fosfato(IP3), que incrementa la concentración de calcio intracelular y del diacilglicerol(DAG), que activa la proteín-quinasa C. Por otro lado, se produce la activación de proteínas BLNK, Tec quinasas, PLC y GEF (guanine Exchange factor), el que activa Ras y Rac, los cuales a su vez activan la vía de las MAP quinasas. Todas estas vías producen la activación de diversos factores de transcripción, como NF-κB, NFAT y AP1, capaces de regular la transcripción de diversos genes. Las inmunodeficiencias genéticas de algunas de las moléculas, que participan en la cascada de señalización de la activación del receptor de células B funcional(BCR) producen distintos fenotipos, entre los cuales se encuentra el detenimiento de la transición de células pro-B a pre-B.
Alteración de transferasas en pacientes con Dengue en un Hospital Provincial de Córdoba
Authors: Zini Isabel Cecilia , Gallego Fernando , Collino César Juan Gerrardo
Published: October 2024

Diferentes parámetros de laboratorio se ven alterados durante el curso de la infección el virus del Dengue. Su determinación y seguimiento es indispensable para evaluar la evolución del paciente infectado. Si bien la elevación de las transferasas (ASAT y ALAT) es un hallazgo frecuente, en la mayoría de los casos leve y autolimitada, su cuantificación es un elemento importante para valorar la función hepática, cuya afectación puede llevar al paciente a cuadros clínicos graves y potencialmente fatales. El objetivo del presente estudio fue realizar un análisis sobre el comportamiento de diferentes parámetros de laboratorio, especialmente de las enzimas ASAT y ALAT, durante la infección por el virus del dengue. Se analizaron las historias clínicas de 108 pacientes con diagnóstico de dengue confirmado que asistieron al Hospital G. Rawson de la ciudad de Córdoba en el período comprendido entre enero y abril de 2016. Equipamiento empleado: autoanalizador químico TARGA-BT3000 Plus (Wiener) y contador hematológico CELL-DYN 1800 (Abbott). El análisis estadístico de los datos se realizó con el Software Infostat versión 2011. Se observó un descenso significativo del recuento de glóbulos blancos y plaquetas a partir del tercer día luego del comienzo de los síntomas. El aumento de las transferasas se evidenció en un 84,3% y 75,9% para ASAT y ALAT respectivamente. No se encontró un incremento diferencial entre estas enzimas, así como tampoco entre el incremento en los pacientes ambulatorios respecto de los internados. Demostramos un incremento paulatino de los niveles de transferasas en los primeros días de la infección.
Metaloproteínas transportadoras de hierro en plasma seminal y su posible función como moléculas reguladoras del metabolismo espermático
Authors: Brufman Adriana , Brunori Magalí , Raspo Esteban
Published: October 2024

Introducción: el plasma seminal (PS) es un modulador de la función espermática; por esta razón, es necesario caracterizar adecuadamente su composición molecular. El hierro (Fe) juega un papel importante en la espermatogénesis. En el transporte, la captación celular y el almacenamiento de hierro intervienen la transferrina (Tf), el receptor celular de membrana de la transferrina y la ferritina (FN), respectivamente. Las vías metabólicas del Fe en los testículos aún se desconocen. Objetivos: el objetivo del trabajo fue estudiar componentes bioquímicos como proteínas totales, (Pt), Fe, FN y Tf, en PS de individuos jóvenes y establecer valores referenciales para nuestro laboratorio. Luego, estos valores se relacionaron con parámetros del espermograma y producción de especies reactivas del oxígeno (ERO), a fin de conocer la fisiología del hierro en el testículo. Materiales y métodos: se estudiaron 115 muestras de semen y suero; en ambos fluidos se determinó la concentración de Tf, Fe, Pt y FN. Se realizó un espermograma básico y medición de ERO (T- Bars, MOST, nitritos). Resultados y conclusión: los marcadores bioquímicos estudiados fueron significativamente diferentes en plasma seminal y suero, y no se encontró relación entre los mismos. La concentración de Tf en PS tiene relación lineal directa con la concentración espermática y la movilidad. Se evidenció una relación inversa entre el estrés oxidativo y los niveles de Tf testicular, la cual podría deberse a su función antioxidante en PS. El conocimiento de los mecanismos fisiopatológicos de la función espermática es de gran importancia para elección del diagnóstico y tratamiento.
Alteraciones lipídicas en pacientes pediátricos infectados con VIH bajo tratamiento antirretroviral con inhibidores de proteasa
Authors: Sanchez María Florencia , Balbaryski Jeanette , Candi Marcela , Gaddi Eduardo , Barboni Graciela
Published: October 2024

Introducción: La infección por el virus de la inmunodeficiencia humana y el tratamiento antirretroviral están asociados a cambios bioquímicos y metabólicos e incluyen modificaciones en los perfiles lipídicos. Objetivo: Describir la modificación en los valores de los triglicéridos asociada con la incorporación al tratamiento antirretroviral de un inhibidor de proteasa y los efectos a largo plazo sobre dichos niveles. Materiales y métodos: Se estudiaron retrospectivamente pacientes infectados con el virus de inmunodeficiencia humana, seguidos en el Hospital General de Niños Pedro de Elizalde, que presentaron en algún momento de la evolución de la enfermedad niveles de triglicéridos superiores al valor de referencia (150 mg/dl). Los valores de triglicéridos, linfocitos T CD4+ y carga viral fueron registrados antes y después de la incorporación del fármaco. Resultados: Los 26 pacientes que cumplieron los criterios de inclusión presentaron niveles de linfocitos T CD4+ y carga viral con un rango amplio de variabilidad, sin diferencias significativas entre los momentos evaluados. Los triglicéridos presentaron un aumento significativo en el 88 % de los pacientes. Se observó un incremento significativo en el grupo con mayor compromiso inmune (mediana: 150 mg/dl, rango: 54 - 266 mg/dl y 332 mg/dl, 76 - 938 mg/ dl). De los 8 pacientes estudiados a largo plazo, 7 presentaron valores medios superiores a 150 mg/dl (rango 185 - 348 mg/dl).
Experimental investigation of the Performance of Natural Circulation Solar Water Heater in Series
Authors:   Water Affairs Higher Technical Institute -Al-Egailat, Libya, Khoder Mohammed.I.
Published: October 2024

This research paper presents an experimental study on the performance of a natural circulation solar water heater system with two typical collectors connected in series. The paper provides a comprehensive analysis of the system's thermal performance under different load conditions, including no-load, intermittent, and continuous load. Mean storage tank, solar collector means plate (the left) temperature and thermosyphon flow rate in a vertical tank were measured. Results showed that there was variation in solar water tank and collector plate temperature under load and no-load conditions. Analysis of thermal performance of the system was conducted for each condition. The highest plate temperature (100 ˚C or even more) with no circulation of both collector and load conditions, indicate the high quality of the solar collectors even during the cold season. The collector’s arrangement in series connection is of highest gain in energy and higher storage tank mean water temperature. Several characteristic equations obtained to represent the performance of the present natural circulation system under collector connection arrangement in series. In fact, when large amount of hot water was required for a certain purpose (Industrial sector for example - MSF plant or central heating), multiple collectors are to be deployed in series and in parallel to produce the required amount (quantity) and desired temperature (quality) at the same time. Key words: Thermosyphon solar water heater, storage tank profile temperature, Solar Water Heaters (SWHs), instantaneous efficiency, collector flow factor, collector efficiency factor, collector heat removal factor
Advanced and AI Embedded Technologies in Education: Effectiveness, Recent Developments, and Opening Issues
Authors: Nguyen Minh T. , Nguyen Thuong TK.
Published: October 2024

This paper offers a brief analysis highlighting the effectiveness of several well-known Artificial Intelligence (AI) technologies applied in education, particularly in teaching and learning. It provides an overview of how modern classrooms can benefit from more effective teaching strategies that encourage students to engage in hands-on learning. Advanced technologies are changing how knowledge is found and shared, as well as how teaching is delivered. Memorization has been emphasized in educational models as a crucial learning skill until relatively recently. The technologies alter how knowledge is accessed and taught in schools today. Based on that, most knowledge is readily available, quickly accessible, and available online. The skills of reading, sharing, listening, and acting are now prerequisites for schooling. Most recent developments in advanced technologies in education are provided. Some analyses related to opening issues and challenges are shown for future work.
Strategic Analysis from a consulting context for the Super Kinder School Institution
Authors: Sanguino Navarro Willington , Arias Duque Nubia Esmeralda , Botia Ramirez Freyman Mauricio , Tavera Chaparro Angelica Maria
Published: October 2024

In the current dynamic, managers of educational institutions such as Super Kinder School seek correct decisions to enhance internal efficiency and meet organizational objectives. A strategic analysis was carried out applying the interpretivist methodology through a case design and an interview with the director of the institution. This qualitative approach has given rise to strategic matrices such as Porter's Five Forces, EFE, EFI, IE, SWOT, PEYEA, MPCE, MIC MAC, complemented by the Balanced Scorecard tool.
Strategies focused on market growth, product and service development, and market penetration were identified, seeking to improve internal processes and promote the growth of Super Kinder School. The consultancy is aimed at addressing essential activities for the continuous development of Super Kinder School, requiring a deep understanding of the institution, its achievements and educational service
Análisis jurídico comparativo entre la legislación ecuatoriana y argentina respecto a la adopción homoparental [Comparative legal analysis of Ecuadorian and Argentinean legislation on same-parent adoption]
Authors: Erazo-Yar Adriana Analy , Ayala-Villarreal Zully Anabel , Nazate-Tobar Alison Nallely , Puetate-Paucar Jairo Mauricio
Published: October 2024

La adopción homoparental se ha convertido en un eje fundamental de los debates contemporáneos sobre derechos humanos, igualdad y protección de los menores. En conformidad con lo anterior; se presenta como objetivo formular un análisis jurídico comparativo entre la legislación ecuatoriana y argentina respecto a la adopción homoparental. El corpus documental analizado estuvo compuesto por 15 artículos científicos y jurisprudenciales. El análisis comparado revela que la adopción homoparental en Ecuador enfrenta importantes obstáculos tanto en el plano legal como social, lo que genera una evidente desigualdad en el acceso a este derecho. Esto contrasta notablemente con el caso argentino, donde la aprobación de la ley de matrimonio igualitario ha consolidado el derecho a la adopción para las parejas del mismo sexo, garantizando una mayor seguridad jurídica y una efectiva protección de los derechos de los menores.
Assessing the Reliability, Dimensions, and Variance of Young's Internet Addiction Test by Applying it to Adolescents at the National Psychiatric Hospital in Costa Rica
Authors: Martín Herrero José A. , Fernández Mora Karla , Molina Fernández Antonio
Published: October 2024

Background: The Internet Addiction Test (IAT) was the first instrument created specifically to assess Internet addiction (IA). Although it was not validated during its creation, its validity has since been confirmed thanks to subsequent studies. The IAT is the first global psychometric measure tested worldwide that has been used in several studies as a research tool. Regarding the dimensions of the IAT, they were not reported by the creator of the test, during the performed factor analysis. Nonetheless, different studies have defined the test as being one-dimensional and others as having three, four, five, and six dimensions.  
Methods: In the present study, seven dimensions were identified; however, there is still a lack of consensus about the number of dimensions that accurately define this test.  
Results: Hence, Young's Internet Addiction Test presents a shortcoming that may be explained by the influence of several factors such as how it was applied, the place where it was applied, and the population to which it was applied. All of these are factors that could be linked to the sociocultural aspects of the adaptations that have been made to the test.  
Conclusions: Moreover, the first dimension of the IAT found, the loss of self-control, is extremely important because it explains 34% of the variance of the data. However, 74% of the variance is explained by applying the 7 dimensions identified in this research. Also, the reliability analysis showed that the IAT is 89% reliable, which indicates that the elements comprising the test used in this research are suitable for measuring the construct of Internet addiction.
Confirmatory Factor Analysis of the Sustainable Development Goals Derived Gentrification Scale in the Context of the Pandemic
Authors: Crespo Julio E. , Lirios Cruz García , Campas Celia Yaneth Quiroz , Sánchez Arturo Sánchez , Medina Jorge E. Chaparro , Rodríguez Isabel Cristina Rincón
Published: October 2024

In the context of human development goals, gentrification has emerged as a significant and unpredictable phenomenon amid the ongoing health crisis, potentially impacting the sustainable development goals (SDGs). This study aimed to analyze the theoretical framework of gentrification and its empirical indicators in the unique context of the pandemic, foreseeing potential risk scenarios. A cross-sectional, psychometric, and correlational study was conducted with 100 university students dedicated to the SDGs during the pandemic. The findings revealed the prevalence of two out of seven factors associated with poverty alleviation and institutional justice for peace. Given the observation of seven factors in the current literature, this study recommends expanding the indicators to enhance the variance percentage and aligning the theoretical model with empirical evidence. It underscores the pressing need for collaborative efforts in urban and sustainable development.
Teachers’ Perceptions and Practices of Learner-Centred Grammar Teaching Methodology in Selected Secondary Schools of Oromia Special Zone Surrounding Finfinne
Authors:   Madda Walabu University, Tesfaye Tamirat
Published: October 2024

This study attempted to investigate teachers’ perceptions of learner-centred grammar teaching methodology and their classroom practices. To collect data, three schools were randomly selected in Oromia Special Zone surrounding Finfinne, Ethiopia. The researcher used a mixed approach that included a questionnaire and an interview. In order to fill the questionnaire, twenty-four English teachers were selected using census method since it was manageable. For an interview, four teachers were selected using purposive sampling. The findings of the study revealed that teachers have clear understanding towards learner-centred grammar teaching methodology. However, implementing the methodology was difficult because teachers usually focus on teaching grammar through presenting rules first followed by practicing the examples. In addition, students’ reluctance in actively participating in classroom discussion and fear of making mistakes were other problems. In order to create awareness in the implementation of a learner-centred method in grammar lessons, the concerned bodies like Woreda Education Office, Regional Education Bureau and Ministry of Education should prepare trainings for both teachers and students.
Perceptual Learning Style Preferences (PLSP) and their Relationship with English Foreign Language Achievement
Authors:   Addis Ababa University: Department of Foreign Languages and Literature Addis Ababa; Ethiopia, Firissa Berhanu , Gebremariam Alamirew
Published: October 2024

This study aimed at shedding more light on the roles of perceptual learning style preferences (PLSP) on EFL achievement. The study applied quantitative approach and correlational design. Selected using simple random sampling, 180 grade eleven students were participants of the study. The study employed Reid’s (1984) PLSPQ, and students’ semester final exam results to measure PSLP and FLA, respectively. Six units of grade eleven English textbook was as secondary data. Findings of the study revealed that the major PLSP of the students was group followed by visual, minor PLSP, and negligible others four. Moreover, the activities addressed by the teaching material were found incongruent with the perceived learning styles. Furthermore, results of One-way ANOVA confirmed that PLSP is significantly related with FLA. It was implied that the construct PLSP need to be considerably reflected in the instructional materials preparation towards the EFL students’ success. As a mismatch between activities of teaching materials would result in learners’ failure, teaching materials need to be geared towards PSLP dimensions. Teachers are expected to identify students’ ways of learning and apply accommodating strategies to address individual differences in the classroom in terms of PLSP dimensions.
Impact of Tulsi extract on sealer penetration in dentinal tubules as compared to 17% EDTA as the final root canal irrigant (in vitro analysis)
Authors: Imtiaz Ashar , Musheer Urooj , Khursheed Hassan , Ahmed Salman , Ansari Bilal
Published: October 2024

Introduction: Penetration of endodontic sealers into dentinal tubules is essential for ensuring successful root canal treatment by creating a hermetic seal that prevents reinfection.Traditionally, 17% EDTA has been used as the final irrigant for smear layer removal. However, concerns regarding its limited antimicrobial properties and potential for dentin erosion have prompted the exploration of alternative solutions. This in vitro study compared the effectiveness of Tulsi extract with that of 17% EDTA in promoting sealer penetration within the dentinal tubules. Methodology: Thirty extracted single-rooted teeth were randomly divided into three groups: Group 1, 17% EDTA; Group 2, Tulsi extract; and Group 3, saline control. After preparation, the root canals were irrigated with their respective solutions, filled with gutta-percha, and sealed with a calcium hydroxide-based sealer. Sealer penetration was analyzed using scanning electron microscopy (SEM) at the 2 mm and 5 mm levels from the root apex. Results: The results showed no significant difference in sealer penetration at 2 mm among all the groups. However, at 5 mm, both EDTA and Tulsi groups exhibited significantly greater sealer penetration than the control group (p < 0.001). No significant difference was observed between the EDTA and Tulsi groups at 5 mm (p = 0.706). Conclusion: Tulsi extract demonstrated similar efficacy to 17% EDTA in facilitating sealer penetration, suggesting its potential as a biocompatible and antimicrobial alternative for root canal irrigation protocols. Further studies are warranted to explore its clinical applications and commercial viability.
Long-term performance and environmental reliability of selfhealing materials in structural applications
Authors: Mutha Raj Kamlesh
Published: October 2024

The self-healing capabilities of materials have justifiably emerged as the new promising innovation in structural engineering, having the capability of autonomously repairing damages and thus extending the lifetime of a structure. The paper reviews the existing literature on the long-term performance and environmental reliability of various self-healing materials with regard to application in structure-oriented contexts such as concrete, polymers, and composites. In this paper, the mechanisms that are key to microcapsule-based, vascular, and intrinsic self-healing will be analyzed with regard to their effectiveness with time and different environmental conditions. Challenges and limitations are discussed together with recommendations for future research and practical applications.
Determination of intestinal microbiome of Marchalina hellenica (Gennadius, 1883) (Hemiptera, Margarodidae)
Authors: Tunca Rahsan Ivgin , Ceylan Ozgur , Ozgul Okan
Published: October 2024

Knowledge of the insect microbiota remains largely unexplored. The intestinal microbiome of Marchalina hellenica (Gennadius, 1883) (Hemiptera, Margarodidae) was determined in the current study. This species is the main source of pine honey production. A pool of 100 samples were selected, representing the distribution of M. hellenica in the province of Mugla, Turkey. API Staph tests were used to assess Gram-positive bacteria, while API 20NE and API 20E tests were used to assess Gram-negative bacteria. As a result, 33 Gram-negative and 15 Gram-positive isolates were obtained from samples collected from 44 different locations. Among Gram-positive, 14 out of 15 belonged to Staphylococcus spp. Among Gram-negative, 22 out of 33 belonged to Aeromonas spp. This is the first study intended to determine the intestinal microbiome of M. hellenica.
Exploring Gender-Based Differences in Banking Transactions: A Data-Driven Analysis Using Multiple Linear Models and Permutation Feature Importance
Authors: Ma Nathan
Published: October 2024

This study examines gender-based differences in financial behavior, focusing on various bank transactions and demographic factors using a large dataset from Kaggle, consisting of over one million entries. By applying multiple linear regression models and permutation feature importance rankings, the study explores how different variables, such as age, geographic location, and transactional timing, influence banking patterns across genders. The findings reveal that age is a significant predictor of transaction behavior for males, while it is less impactful for females. Geographic location, particularly “Location_West” and “Location_Other,” plays a crucial role for males but has minimal influence on females. For females, transactional timing, indicated by “TransactionHour,” shows more importance in predicting banking behaviors. In contrast, gender itself does not significantly affect transaction outcomes when controlling for other variables. Overall, the study highlights the importance of demographic and contextual factors, such as age and geography, over inherent genderbased differences. These insights provide valuable guidance for financial institutions aiming to tailor their services more effectively to meet the needs of diverse customer segments. The results emphasize the need for data-driven approaches to better understand gender-specific financial behavior and improve service offerings.
Pengembangan Sistem Informasi Perpustakaan Peminjaman dan Pengembalian Buku Berbasis Website Interaktif
Authors: Yuliyanto Agung , Sari Indah Perdana
Published: October 2024

Library SMA Negeri 1 Mlati still not accurate in data maintenance, so that impact on often happened mistake or not discipline in delay of return of book. In addition to obtaining information relating to the collection of books takes a long time. So that the System will run the System that can help librarians SMA Negeri 1 Mlati in the process of management of computerized data administration and System that can provide information to the librarian of SMA Negeri 1 Mlati for borrowers who have not returned the book. The purpose to facilitate officers in processing transactions and maintain data collection of books on the Library SMA Negeri 1 Mlati. The system development method used is the Prototype methodology which includes the identification of user needs, prototype creation, prototype testing, and prototype improvement. For data collection method using observation and interview method. For system model used is Context Diagram, Data Flow Diagram (DFD) and Entity Relationship Diagram (ERD). The software for the design and implementation of the program using Apache as a web server, mySQL as a database server, Sublime Text 3 as a writing editor programming language PHP and HTML. Results or output to be achieved that is generated library system that can handle data administration, data maintenance, and information borrower books on the library. The final stage is to implement an information system that includes the implementation of software, hardware, database and interface of the resulting system.
بناء جسور بين الإسلام والديانات الإبراهيمية الأخرىمن خلال تحليل الإشارات القرآنية لليهودية والمسيحية
Authors: وان روي , يانغ يو تشينغ
Published: October 2024

تهدف هذه الدراسة إلى بناء جسور بين الإسلام والديانات الإبراهيمية الأخرى ( اليهودية والمسيحية ) من خلال تحليل الإشارات القرآنية لهذه الديانات. يتناول القرآن الكريم كثيرًا من الآيات التي تتحدث عن اليهود والمسيحيين، والمعروفين بـ"أهل الكتاب"، ويعترف بكتبهم وأنبيائهم كجزء من رسالة إلهية مستمرة. تستكشف هذه الدراسة آيات قرآنية رئيسية تُظهر القيم المشتركة مثل التوحيد، والتعاطف، والعدالة الاجتماعية، والتقوى، مما يكشف عن قواسم مشتركة يمكن أن تعزز الفهم المتبادل. تبدأ الدراسة بتحديد الآيات التي تؤكد على استمرارية الوحي الإلهي بين هذه الديانات، مُقدمة تراثًا روحيًا مشتركًا. ومن خلال استكشاف كيفية حديث القرآن عن موسى وعيسى وغيرهما من الشخصيات البارزة، تسلط الدراسة الضوء على نقاط الالتقاء بين الإسلام واليهودية والمسيحية، مقدمةً أساسًا للحوار قائمًا على القيم المشتركة والارتباط التاريخي. علاوة على ذلك، تتناول الدراسة مجالات الاختلاف اللاهوتي، مشيرة إلى أن هذه الاختلافات يمكن أن تكون مصادر لتعزيز الحوار الثري الذي يُقدر التنوع الديني بدلاً من أن تكون عوامل للانقسام. كما تركز هذه الدراسة على أهمية تطبيق الرؤى القرآنية في السياقات العصرية للحوار بين الأديان. من خلال إعادة النظر في التفاسير التقليدية واستكشاف دعوات القرآن إلى الاحترام والتعايش والسلام، تقدم الدراسة طرقًا عملية لمواجهة المفاهيم الخاطئة وتقليل التحيزات والحد من الصراعات الدينية. وتؤكد النتائج على ضرورة التعامل مع النصوص الدينية بتعاطف وانفتاح لتعزيز فهم أعمق بين الأديان. تجادل الدراسة بأن القراءة الواعية والمتفهمة للقرآن يمكن أن تكون أداة فعالة لبناء علاقات أقوى وأكثر احترامًا بين أتباع الديانات المختلفة، داعية إلى الحوار والشراكة على أساس القيم المشتركة لمواجهة التحديات العالمية، ورؤية التنوع الديني كنعمة إلهية وأساس لبناء السلام المشترك.
COMPARISON OF VEGETARIANS AND NON-VEGETARIANS IN BODY MASS INDEX INDICATORS AND CHOLESTEROL LEVELS
Authors: Helen Sabatini Simbolon, Yunus Elon
Published: October 2024

Background: Nutritional status of adults can be seen simply by using body mass index, and especially nutritional status related to vegetarian and nonvegetarian dietary status.Objective: This study aimed to assess the cholesterol levels and BMI of Adventist University Indonesia students. Methods: Using Spearman's rho test, this research technique is quantitative. There were 60 participants who voluntarily gave their consent. The tool used in this study is a lipid profile (measuring tool for cholesterol levels), Results: the study showed that there was no relationship between gender and BMI. While there is a significant relationship to dietary status and cholesterol levels with a unidirectional positive value (p = .000 r = .578).
HUBUNGAN PENGETAHUAN DAN SIKAP DENGAN TINDAKAN PENCEGAHAN PADA PENYINTAS COVID-19 DI KECAMATAN TOMOHON TENGAH
Authors: Suba Baithesda , Palenkahu Noldy , Mangowal Orlando Renaldo
Published: October 2024

Alasan Peneliti Mengambil variabel penelitian tersebut adalah, untuk melihat bagaimana gambaran Pengetahuan dan Sikap Dengan Tindakan Pencegahan Pada Penyintas Covid-19 Di Wilayah Kerja Puskesmas Kecamatan Tomohon Tengah  Jenis penelitian  menggunakan jenis kuantitatif dengan desain korelasional cross-sectional  Pendekatan ini digunakan karena pada desain studi ini seluruh variable diukur dan diamati pada saat yang sama (one point in time) sehingga lebih memudahkan peneliti dalam melakukan penelitian  Dalam penelitian ini program analisis data yang akan digunakan adalah SPSS (Statistic Program for Social Science) versi 26  Hal ini dilakukan untuk mencakup Uji Chi-Square  Analisis ini dilakukan untuk mengetahui hubungan pengetahuan dan sikap pada penyintas dalam upaya penceghan Covid-19 di wilayah kerja puskesmas Matani
HUBUNGAN BEBAN KERJA DENGAN STRES PERAWAT RAWAT INAP COVID-19 DAN IGD DI RSU SILOAM
Authors: Bangkut Margaretha , Kalangi Veronica , Liuw Syendy
Published: October 2024

Beban kerja adalah kelengkapantata kerja yang dialami seseorang baik secara kelembagaan, lingkungan, personal (fisik dan psikologis)maupun situasional.  Stres kerja perawat dapat digunakan dalam menjelaskan suatu tuntutan seseorang dalam beradaptasi ataupun suatu reaksi seseorang terhadap tuntutan tersebut.  Tujuan penelitian ini adalah diketahuinya hubungan antara beban kerja dengan stres kerja perawat Ruang Rawat Inap Non Covid-19 dan IGD di RSU GMIM Siloam Sonder.  Metode penelitian yang digunakan yaitu menggunakan jenis penelitian kuantitatif dengan desain penelitian Cross Sectional.  Sampel dalam penelitian ini sebanyak 33 orang dengan teknik pengambilan data menggunakan teknik total sampling. Instrumen yang digunakan adalah dengan menggunakan skala likert dan di analisis menggunakan uji statistic Spearman Rho.Hasil di analisis didapatkan nilai koefisien korelasi  (r ) = 0. 931dan r tabel = 0.291, dengan tingkat signifikan (p)=0.000< α 0.005 dengan tingkat hubungan sangat kuat sehingan H1 diterima H0 ditolak.  Kesimpulan ada hubungan beban kerja menunjukkan hubungan sangat kuat  dengan stres kerja perawat Ruang Rawat Inap Non Covid-19 dan IGD di RSU GMIM Siloam Sonder
Remoção de odontoma composto com enxerto ósseo associado a tracionamento de canino: relato de caso
Authors: Araújo Giovana Arruda Damasceno de , Gonçalves Junior Fernando dos Santos , Borges Luã Lopes , Borges Alberto Tadeu do Nascimento , Lopes Zobélia Maria de Souza
Published: October 2024

Os odontomas são tumores benéficos odontogênicos sem conduta agressiva e de crescimento tardio, podendo ocasionar na progressão da dentição e da oclusão do paciente sérios problemas. A presença de dentes impactados pode, portanto, promover ou apresentar-se associado a lesões como odontoma. No caso de um dente impactado associado a uma lesão, os profissionais se deparam com duas situações coexistentes que devem ser tratadas de forma otimizada para a lesão e decisões envolvidas por meio de testes diagnósticos e conhecimento sobre a prevalência e patogenicidade da lesão e opções de tratamento e decidir o destino mais indicado para o dente impactado envolvido. Paciente K.A.P.S., sexo masculino, leucoderma, 13 anos, compareceu à clínica integrada da Faculdade do Amazonas – IAES com a queixa principal “Quero colocar aparelho para arrumar os dentes”. Durante a anamnese o paciente afirmou não possuir alterações sistêmicas e não ter realizado tratamento ortodôntico anteriormente. O tratamento proposto foi a exérese total da lesão associado a enxertagem óssea do elemento 73 além do tracionamento ortodôntico do elemento 33. O objetivo deste trabalho foi relatar um caso clínico de remoção de odontoma composto com posterior enxertia óssea associado a tracionamento ortodôntico. Concluiu-se que a abordagem terapêutica integrada, envolvendo a excisão de odontoma composto, seguida da aplicação de enxerto ósseo e tracionamento ortodôntico subsequente, resultou em um desfecho clínico favorável.
Image-based identification and isolation of micronucleated cells to dissect cellular consequences
Authors: DiPeso Lucian , Pendyala Sriram , Huang Heather Z , Fowler Douglas M , Hatch Emily M
Published: October 2024

Recent advances in isolating cells based on visual phenotypes have transformed our ability to identify the mechanisms and consequences of complex traits. Micronucleus (MN) formation is a frequent outcome of genome instability, triggers extensive disease-associated changes in genome structure and signaling coincident with MN rupture, and is almost exclusively defined by visual analysis. Automated MN detection in microscopy images has proved extremely challenging, limiting unbiased discovery of the mechanisms and consequences of MN formation and rupture. In this study we describe two new MN segmentation modules: a rapid model for classifying micronucleated cells and their rupture status (VCS MN), and a robust model for accurate MN segmentation (MNFinder) from a broad range of fluorescence microscopy images. As a proof-of- concept, we define the transcriptome of non-transformed human cells with intact or ruptured MN after inducing chromosome missegregation by combining VCS MN with photoactivation-based cell isolation and RNASeq. Surprisingly, we find that neither MN formation nor rupture triggers a strong unique transcriptional response. Instead, transcriptional changes appear correlated with small increases in aneuploidy in these cell classes. Our MN segmentation modules overcome a significant challenge with reproducible MN quantification, and, joined with visual cell sorting, enable the application of powerful functional genomics assays, including pooled CRISPR screens and time-resolved analyses of cellular and genetic consequences, to a wide-range of questions in MN biology.
Contrasting responses to aridity by different-sized decomposers cause similar decomposition rates across a precipitation gradient
Authors: Torsekar Viraj R , Sagi Nevo , Daniel J Alfred , Hawlena Yael , Gavish-Regev Efrat , Hawlena Dror
Published: October 2024

Litter decomposition is expected to be positively associated with precipitation despite evidence that decomposers of varying sizes have different moisture dependencies. We hypothesized that higher tolerance of macro-decomposers to aridity may counterbalance the effect of smaller decomposers, leading to similar decomposition rates across climatic gradients. We tested this hypothesis by placing plant litter baskets of different mesh sizes in seven sites along a sharp precipitation gradient, and by characterizing the macro-decomposer assemblages using pitfall trapping. We found that decomposers responded differently to precipitation levels based on their size. Microbial decomposition increased with precipitation in the winter while macro-decomposition peaked in arid sites during the summer. This led to similar overall decomposition rates across the gradient except in hyper-arid sites. Macro-decomposer richness, abundance, and biomass peaked in arid environments. Our findings highlight the importance of macro-decomposition in arid-lands, possibly resolving the dryland decomposition conundrum, and emphasizing the need to contemplate decomposer size when investigating zoogeochemical processes.
Early steps of protein disaggregation by Hsp70 chaperone and class B J-domain proteins are shaped by Hsp110
Authors: Sztangierska Wiktoria , Wyszkowski Hubert , Pokornowska Maria , Kochanowicz Klaudia , Rychłowski Michal , Liberek Krzysztof , Kłosowska Agnieszka
Published: October 2024

Hsp70 is a key cellular system counteracting protein misfolding and aggregation, associated with stress, ageing, and disease. Hsp70 solubilises aggregates and aids protein refolding through substrate binding and release cycles regulated by co-chaperones: J-domain proteins (JDPs) and nucleotide exchange factors (NEFs). Here, we elucidate the collaborative impact of Hsp110 NEFs and different JDP classes throughout Hsp70-dependent aggregate processing. We show that Hsp110 plays a major role at initial stages of disaggregation, determining its final efficacy. The NEF catalyses the recruitment of thick Hsp70 assemblies onto aggregate surface, which modifies aggregates into smaller species more readily processed by chaperones. Hsp70 stimulation by Hsp110 is much stronger with class B than class A JDPs and requires the auxiliary interaction between class B JDP and the Hsp70 EEVD motif. Furthermore, we demonstrate for the first time that Hsp110 disrupts the JDP-Hsp70 interaction. Such destabilisation of chaperone complexes at the aggregate surface might improve disaggregation, but also lead to the inhibition above the sub-stoichiometric Hsp110 optimum. Thus, balanced interplay between the co-chaperones and Hsp70 is critical to unlock its disaggregating potential.
A new potential strategy for cutaneous squamous cell carcinoma treatment by generating serum-based antibodies from tumor-exposed mice
Authors: Liu Zheng
Published: October 2024

Current cancer treatment strategies continue to face significant challenges, primarily due to tumor relapse, drug resistance, and low treatment efficiency. These issues arise because certain tumor cells adapt to the host immune microenvironment and evade the immune system. This study presents a new cancer immunotherapy strategy using serum-based antibodies from mice exposed to mouse cutaneous squamous cell carcinoma (mCSCC). The experiment was conducted in three stages. In the first stage, mCSCC cells were isolated and expanded cultured from DMBA/TPA-induced mCSCC. In the second stage, these expanded tumor cells were injected into healthy mice to stimulate the production of anti-tumor antibodies. In the final stage, therapeutic serum was extracted from these healthy mice and reintroduced into the tumor-bearing mice. An ELISA assay was utilized to analyze the levels of p53, Bcl-xL, NF-κB, and Bax. The results showed that the serum treatment not only reduced tumor volume but also reversed changes in p53, Bcl-xL, NF-κB, and Bax. In conclusion, this study developed a new immunotherapeutic strategy for treating mCSCC. However, further research is needed to fully comprehend the mechanism of this serum treatment.
Predictive models for secondary epilepsy within 1 year in patients with acute ischemic stroke: a multicenter retrospective study
Authors: Liu Jinxin , He Haoyue , Wang Yanglingxi , Du Jun , Liang Kaixin , Xue Jun , Liang Yidan , Chen Peng , Tian Shanshan , Deng Yongbing
Published: October 2024

Post-stroke epilepsy (PSE) is a significant complication that has a negative impact on the prognosis and quality of life of ischemic stroke patients. We collected medical records from 4 hospitals in Chongqing and created an interpretable machine learning model for prediction.We collected medical records, imaging reports, and laboratory tests from 21459 patients with a diagnosis of ischemic stroke. We conducted traditional univariable and multivariable statistics analyses to compare and identify important features. Then the data was divided into a 70% training set and a 30% testing set. We employed the Synthetic Minority Oversampling Technique combined with Edited Nearest Neighbors method to resample an imbalanced dataset in the training set. Nine commonly used methods were used to build machine learning models, and relevant prediction metrics were compared to select the best-performing model. Finally, we used SHAP(SHapley Additive exPlanations) for model interpretability analysis, assessing the contribution and clinical significance of different features to the prediction.In the traditional regression analysis, complications such as hydrocephalus, cerebral hernia, uremia, deep vein thrombosis; significant brain regions included the involvement of the cortical regions including frontal lobe, parietal lobe, occipital lobe, temporal lobe, subcortical region of basal ganglia, thalamus and so on contributed to PSE. General features such as age, gender, and the National Institutes of Health Stroke Scale score, as well as laboratory indicators including WBC count, D-dimer, lactate, HbA1c and so on were associated with a higher likelihood of PSE. Patients with conditions such as fatty liver, coronary heart disease, hyperlipidemia, and low HDL had a higher likelihood of developing PSE. The machine learning models, particularly tree models such as Random Forest, XGBoost, and LightGBM, demonstrated good predictive performance with an AUC of 0.99.The model built on a large dataset can effectively predict the likelihood of PSE, with tree-based models performing the best. The NIHSS score, WBC count and D-dimer were found to have the greatest impact.
A bike-sharing demand prediction model based on Spatio-Temporal Graph Convolutional Networks
Authors: Zhou Chaoran , Hu Jiahao , Zhang Xin , Li Zerui , Yang Kaicheng
Published: October 2024

Shared bikes, as an eco-friendly transport mode, facilitate short commutes for urban dwellers and help alleviate traffic. However, the prevalent station-based strategy for bike placements often overlooks urban zones, cycling patterns, and more, resulting in underutilized bikes. To address this, we introduce the Spatio-Temporal Bike-sharing Demand Prediction (ST-BDP) model, leveraging multi-source data and Spatio-Temporal Graph Convolutional Networks (STGCN). This model predicts spatial user demand for bikes between stations by constructing a spatial demand graph, accounting for geographical influences. For precision, ST-BDP integrates an attention-based graph convolutional network for station demand graph’s temporal-spatial features, and a sequential convolutional network for multi-source data (e.g., weather, time). In real dataset, experimental results show that ST-BDP has excellent performance with mean absolute error (MAE) = 1.62, mean absolute percentage error (MAPE) = 15.82%, symmetric mean absolute percentage error (SMAPE) = 16.14%, and root mean square error (RMSE) = 2.36, outperforming the baseline techniques. This highlights its predictive accuracy and potential to guide future bike-sharing policies.
Age trends of genetic parameters and genotype-by-environment interactions for growth traits of Eucalyptus urophylla clones in South-China
Authors: Li Guangyou , Lu Zhaohua , Yang Deming , Hu Yang , Xu Jianmin
Published: October 2024

Eucalyptus urophylla S.T. Blake, an important economic tree species, is widely cultivated as a raw material source for pulpwood, veneer plywood, and sawlog timber in southern China. As a tree in multiple environments, tree-breeding programs can assess genotype by environment (G × E) interactions and identify the suitable genotype for a specific environment. G × E interactions related to growth traits and soil factors have not been adequately studied for clones of Eucalyptus urophylla and its hybrids. To examine this important question, trials containing 20 clones of E. urophylla and its hybrids were established at three sites in southern China: Shankou (SK), Tiantang (TT), and Xiniujiao (XNJ). These sites each have different soil conditions but similar geographical and climatic conditions. With the data across nearly eight years, average phenotypic trends and broad sense repeatability (H2) were modeled, G×E interactions between clones and diverse soil environments were estimated, genetic gains of clones were calculated, and the adaptabilities of E. urophylla clones in different soil environments were compared. Average survival trends for clones tended to show a moderate decrease while growth traits tended to show sharp increases with age. At the same age, sites were ordered for average survival and growth traits as TT>SK>XNJ while H2 values for growth traits by site followed the basic order TT>SK>XNJ. The H2 values for growth traits at SK tended to increase at first, platform, and then smooth with age. The H2 values for growth traits at TT were high and stable across ages, and those at XNJ tended to undulate largely at a relatively low level across ages. Genetic correlations for growth traits between any pair of sites tended to increase at first and then decrease. A genetic correlation was strong between SK and TT, intermediate between SK and XNJ, and weak between TT and XNJ. It was concluded that: (1) clones tended to be adapted better to an environment with acidic and loamy soil with a clay content of about 45.6%, the soil depth from the surface to parent material about 1.5 m, and the previous vegetation of Eucalypts. (2) The G×E interactions between clones and sites are weaker if the environmental conditions between the sites are similar, and which are stronger if the environmental conditions between the sites are different. (3) The optimum selection age for clones ranged from 1.5 to 3.5 years old, while the optimum selection growth trait is individual tree volume.