bluuebunny/crossref_metadata_2025 huggingface dataset:
A Balanced Time Perspective and Burnout Syndrome in the Corporate World
Authors: Klamut Olga , Olivera-Figueroa Lening A. , Weissenberger Simon
Published: November 2022

Burnout syndrome is officially classified in the International Classification of Diseases as an occupational phenomenon resulting from chronic workplace stress. Each year it is having an increasingly negative impact on the mental and physical health of employees, as well as on health costs and business performance. With this study, we aim at verifying whether there is a greater propensity for burnout depending on an individual’s time perspective, based on the framework of Christina Maslach’s burnout syndrome theory (consisting of three burnout dimensions), and Phillip Zimbardo’s Time Perspective (consisting of five distinct temporal profiles). Within the time perspective construct, we focused on an indicator of temporal adaptation, referred to as a Balanced Time Perspective (BTP). We used the Maslach Burnout Inventory and the Zimbardo Time Perspective Inventory on a sample of 129 Polish corporate employees. We found that two dimensions of burnout (emotional exhaustion and feelings of personal achievement) were significantly correlated to a balanced time perspective, while the third (depersonalization) did not pose a significant correlation. This underlines the interrelationships between personality and burnout, which gives way to one possible solution towards the danger of burnout syndrome—balancing an individuals’ time perspective through measures such as Time Perspective Therapy. We believe that the awareness of one’s temporal profile gives way to supplement gaps in one time perspective, while deterring the excessive effects of another, resulting in a more balanced time perspective, greater mental health and protection from burnout syndrome.
Sexual Violence against Adolescents in the State of Espírito Santo, Brazil: An Analysis of Reported Cases
Authors: Luis Mayara Alves , Leite Franciéle Marabotti Costa , Letourneau Nicole , Monroy Nátaly Adriana Jiménez , de Godoi Luciana Graziela , Lopes-Júnior Luís Carlos
Published: November 2022

Objective: We describe the prevalence of the reported cases of sexual violence against adolescents and analyze their associated factors. Methods: A cross-sectional analytical study (n = 561) was conducted with reported data on sexual violence against adolescents in the state of Espírito Santo registered in SINAN between 2011 and 2018 to understand the prevalence and predictors of sexual violence against adolescent victims, as well as to describe the perpetrators and the nature of the aggression. Variables to characterize the victim, aggression, and perpetrator were used. Bivariate analyses were performed using chi-square (χ2) and Fisher’s exact tests, and multivariate analyses were conducted using log-binomial models; the results were presented with prevalence ratios. All analyses were stratified by sex. Results: The prevalence of sexual violence was 32.6%, and 93% of the victims were female. In both males and females, the reported sexual violence was associated with a younger age (10–12 years old), living at home, being related to the perpetrator, and a history of sexual violence. In females, the reported sexual violence was also associated with the number of perpetrators, and in males, with the perpetrator’s age. Conclusions: Our findings show the high frequency of reporting of sexual violence and the characteristics of the victim, the aggression, and the aggressor as factors associated with its occurrence in both sexes. The importance of health information systems for disseminating data and the need for measures to prevent and treat the violence among adolescents is urgent.
Mothering a Child with ADHD in the Ultra-Orthodox Community
Authors: Budman Jennifer , Maeir Adina
Published: November 2022

Mothers of children with ADHD are at risk for negative health outcomes. The socio-cultural environment and everyday experiences in life roles may influence psychological health and quality of life. The ultra-orthodox Jewish (UOJ) community is an insular community who is underrepresented in the research, and as such there are no studies exploring the experience of mothering a child in this community. Thus, this study aims to explore the lived experience of mothering a child with ADHD in the UOJ community. The study used a descriptive qualitative phenomenological approach. Ten UOJ mothers of children with ADHD underwent semi-structured in-depth interviews to explore their lived experiences of mothering a child with ADHD. Thematic analysis was carried out on the transcripts. Four main themes, along with several subthemes, emerged from the qualitative analysis: child ADHD manifestations, maternal role, social factors, and self-care. Unique characteristics of the UOJ culture were apparent throughout the themes. UOJ children with ADHD display similar manifestations of symptoms in daily life to those in the general population and maternal burden is similarly present. However, unique perceptions of their maternal role, social factors, and legitimacy for self-care shed light into the impact of this culture on their lived experience. Findings may help promote culturally sensitive health care and interventions for this understudied population.
Do the Age and Gender of Chairperson Affect Firms’ Environmental Protection Investment?
Authors: Han Libin , Peng Chong
Published: November 2022

Environmental investment of companies can not only bring profits to firms but also contribute to environmental protection. However, little is known about how chairperson characteristics affect companies’ decisions on environmental investment. This paper fills the gap in the literature by studying the impact of chairperson characteristics on firms’ environmental investment. For empirical evidence, we conduct a regression on environmental protection disclosure data of Chinese listed companies sourced from the CSMAR database. We find that China’s overall environmental protection disclosure level is relatively low. The age of the chairperson has an inverted U-shaped relationship with environmental investment, and a female chairperson has a significant positive effect on environmental investment. Contrarily, the education level and political connections of the chairperson have no significant impact on firms’ environmental investment. Understanding the effect of these factors will help companies plan their environmental protection activities more efficiently.
Restorative Effects from Green Exposure: A Systematic Review and Meta-Analysis of Randomized Control Trials
Authors: Song Song , Tu Ruoxiang , Lu Yao , Yin Shi , Lin Hankun , Xiao Yiqiang
Published: November 2022

Despite growing research on green space and health benefits, the body of evidence remains heterogeneous and unclear. A systematic review and meta-analysis of studies of randomized controlled trials (RCTs) with high evidence levels are deemed timely. We searched Scopus, PubMed, Embase, and Web of Science for the literature up to January 2022 and assessed bias using the Cochrane Risk of Bias tool 2.0. We calculated joint impact estimates for each green space exposure assessment technique using random and fixed effects models. Compared to non-green space situations, green space exposure was related to decreased negative feelings, such as fatigue −0.84 (95% CI: −1.15 to −0.54), and increased levels of pleasant emotions, such as vitality 0.85 (95% CI: 0.52 to 1.18). It also lowered physiological indicators, including heart rate levels, by 0.60 (95% CI: −0.90 to −0.31). Effect sizes were large and statistically significant, and the overall quality of the evidence was good. Existing RCTs on greenspace exposure pay insufficient attention to older and adolescent populations, different ethnic groups, different regions, and doses of greenspace exposure interventions. More research is needed to understand how and how much green space investment has the most restorative benefits and guide urban green space planning and renewal.
Psychiatrists’ Experience of a Peer Support Group for Reflecting on Patient Suicide and Homicide: A Qualitative Study
Authors: Tamworth Millie , Killaspy Helen , Billings Jo , Gibbons Rachel
Published: November 2022

There is a lack of support for mental health professionals who experience a patient suicide or homicide. This is despite a high likelihood of such an occurrence and the heavy professional and personal toll the experience can take. We conducted 15 interviews with members of a facilitated peer support group run for consultant psychiatrists who have experienced a patient homicide or suicide. Our interviews explored the trauma of the experience as well as the effectiveness of the group in helping the clinician heal. Our results echoed previous research that the experience can be profoundly traumatic. A professionally facilitated, consultant-only peer group specifically dedicated to suicide and homicide were the key components helping participants to process their grief. Mental health trusts should consider setting up facilitated peer support groups for clinicians who experience patient suicide or homicide.
Preventive Behaviors and Information Sources during COVID-19 Pandemic: A Cross-Sectional Study in Japan
Authors: Uchibori Manae , Ghaznavi Cyrus , Murakami Michio , Eguchi Akifumi , Kunishima Hiroyuki , Kaneko Satoshi , Maruyama-Sakurai Keiko , Miyata Hiroaki , Nomura Shuhei
Published: November 2022

Background: individual preventive behaviors are one of the key measures needed to prevent the spread of COVID-19. This study sought to identify the factors associated with the adoption of COVID-19 preventive measures, focusing specifically on information sources. Methods: we conducted a nationally representative cross-sectional survey of 30,053 Japanese adults in February 2021. The survey asked about socioeconomic, health-related, and psychological characteristics, attitudes toward immunization, and the use of information sources regarding COVID-19. We have constructed multivariable logistic regression to estimate the factors associated with the adoption of three preventive measures: 3Cs avoidance, hand hygiene and respiratory hygiene. Results: socioeconomic variables, psychological variables, and the use of information sources are significantly associated with the adoption of preventive measures. The more information sources one uses, the more likely one is to adopt preventive measures. Trust in healthcare professionals is positively associated with adopting preventive measures. On the other hand, negative correlations between trust in social media and preventive behaviors were observed. Conclusions: encouraging access to multiple information sources, utilizing communication channels, and modifying messaging according to target groups are essential to promote COVID-19 preventive measures.
Evaluation of the Functional Status of the Posture Control System in Children with Detected Disorders in Body Posture
Authors: Permoda-Białozorczyk Anna , Olszewska-Karaban Marzena , Permoda Andrzej , Zajt Jolanta , Wiecheć Marek , Żurawski Arkadiusz
Published: November 2022

Screening tests for body posture defects and abnormalities conducted over the past several decades have revealed a significant and constantly increasing problem of health risks in children. A sedentary lifestyle, which is considered to be the primary cause, can result in proprioceptive disorders leading to postural instability. The aim of the study was to find the correlation between the level of proprioceptive control and the number of postural disorders. The study involved a representative group of 1090 children aged 8–10 years, from randomly selected primary schools. Subjects who scored from 1 to 5 points in a prior postural screening test were qualified for the examination of the postural control system. The examination of the postural control system was carried out using an electronic station enabling assessment of postural stability and proprioception. A single leg stance test showed that the number of postural disorders does not significantly impact proprioceptive control. Proprioceptive control was found to significantly increase with the age of the children, and girls presented significantly better proprioceptive control in relation to the boys in each age group.
Spirometry and Smoking Cessation in Primary Care: The ESPIROTAB STUDY, A Randomized Clinical Trial
Authors: Rodriguez-Alvarez María del Mar , Roca-Antonio Josep , Martínez-González Silvia , Vilà-Palau Victoria , Chacón Carla , Ortega-Roca Alexandre , Borrell-Thiò Eulàlia , Erazo Susana , Almirall-Pujol Jordi , Torán-Monserrat Pere
Published: November 2022

This study aims to evaluate the effect of regularly reporting spirometry results during smoking cessation counseling from a primary care physician on the quit rate in adult smokers. Methods: A randomized, two-arm intervention study was conducted at six primary care centers. A total of 350 smokers, ≥18 years of age, who consulted their primary care physician, participated in the study. At the selection visit, smokers who gave their consent to participate underwent spirometry. Subsequently, an appointment (visit 0) was scheduled to complete a nicotine dependence test, a smoking cessation motivation questionnaire, and a sociodemographic questionnaire. Participants were also offered brief, structured advice on how to quit smoking, as well as detailed information on spirometry results. Patients were then randomized and scheduled for follow-up visits at 3, 6, 12, and 24 months. Both arms received brief, structured advice and detailed information on spirometry results at visit 0. At consecutive follow-up visits, the control group only received brief, structured smoking cessation advice, while the intervention group also received information on initial spirometry results at visits 3 and 6, and a spirometry retest at visit 12. Exhaled carbon monoxide testing was used to check smoking cessation. Results: The study included 350 smokers; 179 were assigned to the control group and 171 to the intervention group. Smoking cessation at one year was 24.0% in the intervention group compared to 16.2% in the control group. At two years, it was 25.2% in the intervention group and 18.4% in the control group. Overall, the adjusted odds of quitting smoking in the intervention group were 42% higher than in the control group (p = 0.018). Conclusions: Regular and detailed feedback of spirometry results with smokers increases smoking cessation. Specifically, the likelihood of quitting smoking in the intervention group is 1.42 times higher than in the control group (p = 0.018).
Association of Long Noncoding RNA HOTAIR Polymorphism and the Clinical Manifestations of Diabetic Retinopathy
Authors: Chuang Chih-Chun , Wang Kai , Yang Yi-Sun , Kornelius Edy , Tang Chih-Hsin , Lee Chia-Yi , Chien Hsiang-Wen , Yang Shun-Fa
Published: November 2022

The aim of the current study is to evaluate the possible correlation between the single-nucleotide polymorphisms (SNP) of HOX transcript antisense intergenic RNA (HOTAIR) and the clinical characteristics of diabetic retinopathy (DR). Four loci of HOTAIR SNPs, including rs920778 (T/C), rs12427129 (C/T), rs4759314 (A/G), and rs1899663 (G/T), were genotyped via the TaqMan allelic discrimination for 276 DR individuals and 452 non-DR patients. The distribution frequency of HOTAIR SNP rs12427129 CT [adjusted odds ratio (AOR): 1.571, 95% CI: 1.025–2.408, p = 0.038], HOTAIR SNP rs12427129 CT+TT (AOR: 1.611, 95% CI: 1.061–2.446, p = 0.025), and HOTAIR SNP rs1899663 TT (AOR: 2.443, 95% CI: 1.066–5.595, p = 0.035) were significantly higher in the DR group. Moreover, the proliferative diabetic retinopathy (PDR) subgroup revealed a significantly higher distribution of HOTAIR SNP rs12427129 CT+TT (AOR: 2.016, 95% CI: 1.096–3.710, p = 0.024) and HOTAIR SNP rs1899663 TT (AOR: 4.693, 95% CI: 1.765–12.479, p = 0.002), and the distribution frequencies of HOTAIR SNP rs12427129 CT (AOR: 3.722, 95% CI: 1.555–8.909, p = 0.003), HOTAIR SNP rs12427129 CT+TT (AOR: 4.070, 95% CI: 1.725–9.600, p = 0.001), and HOTAIR SNP rs1899663 TT (AOR: 11.131, 95% CI: 1.521–81.490, p = 0.018) were significantly higher in the female PDR subgroup. Regarding the clinical characters, the DR patients with HOTAIR SNP rs1899663 GT+TT revealed a significantly shorter duration of diabetes compared to the DR patients with HOTAIR SNP rs1899663 GG (10.54 ± 8.19 versus 12.79 ± 7.73, p = 0.024). In conclusion, HOTAIR SNP rs12427129 and rs1899663 are strongly correlated to the presence of DR, especially for a female with PDR.
NAM and TPB Approach to Consumers’ Decision-Making Framework in the Context of Indoor Smart Farm Restaurants
Authors: Joo Kyuhyeon , Lee Junghoon (Jay) , Hwang Jinsoo
Published: November 2022

The movement toward smart farming, which has productivity and eco-friendly roles, is emerging in the foodservice industry in the form of indoor smart farm restaurants. The purpose of this study was to investigate the consumer decision-making processes in the context of indoor smart farm restaurants. The investigational framework was designed around the norm activation model (NAM) and the theory of planned behavior (TPB), with the moderating role of age. In particular, this study merged NAM and TPB to assess the effect of awareness of consumption consequences on consumers’ attitudes as well as the role played by subjective norms in the formation of personal norms. Data were collected from 304 respondents in South Korea. As a result of structural equation modeling, the proposed hypotheses of causal relationships were generally supported, excluding only the relationship between subjective norm and behavioral intention. The moderating role of age was identified in the relationships between (1) subjective norm and attitude, and (2) personal norm and behavioral intention. This study presents not only theoretical contributions as the first empirical study on consumer behavior in the context of indoor smart farm restaurants but also presents practical suggestions from the perspective of green marketing.
Time-Resolved Kinetic Measurement of Microalgae Agglomeration for Screening of Polysaccharides-Based Coagulants/Flocculants
Authors: Zhou Jinxia , Jia Yunlu , Gong Xiaobei , Liu Hao , Sun Chengwu
Published: November 2022

Time-resolved monitoring of microalgae agglomeration facilitates screening of coagulants/flocculants (CFs) from numerous biopolymer candidates. Herein, a filtering-flowing analysis (FFA) apparatus was developed in which dispersed microalgal cells were separated from coagulates and flocs formed by CFs and pumped into spectrophotometer for real-time quantification. Polysaccharides-based CFs for Microcystis aeruginosa and several other microalgae were tested. Cationic hydroxyethyl cellulose (CHEC), chitosan quaternary ammonium (CQA) and cationic guar gum (CGG) all triggered coagulation obeying a pseudo-second-order model. Maximal coagulation efficiencies were achieved at their respective critical dosages, i.e., 0.086 g/gM.a. CHEC, 0.022 g/gM.a. CQA, and 0.216 g/gM.a. CGG. Although not active independently, bacterial exopolysaccharides (BEPS) aided coagulation of M. aeruginosa and allowed near 100% flocculation efficiency when 0.115 g/gM.a. CQA and 1.44 g/gM.a. xanthan were applied simultaneously. The apparatus is applicable to other microalgae species including Spirulina platensis, S. maxima, Chlorella vulgaris and Isochrysis galbana. Bio-based CFs sorted out using this apparatus could help develop cleaner processes for both remediation of harmful cyanobacterial blooms and microalgae-based biorefineries.
Air Pollution Management: A Multivariate Analysis of Citizens’ Perspectives and Their Willingness to Use Greener Forms of Transportation
Authors: Puiu Silvia , Udriștioiu Mihaela Tinca , Velea Liliana
Published: November 2022

The present research aims to understand how air pollution can be managed by public authorities, both central and local, starting from citizens’ perspectives on the issue. Air quality is a real problem, affecting people at multiple levels. Thus, we introduced the following variables to better understand the problem and to be able to formulate theoretical and practical implications for public management: the involvement of authorities in reducing air pollution; the involvement of citizens in reducing air pollution; financial incentives for citizens and companies for adopting behaviors that reduce air pollution; green investments in the city; the impact of air pollution on the community; and the need for independent bodies to monitor air pollution. The research methodology used is partial least squares structural equation modelling (PLS-SEM) and the required data were gathered from issuing a survey to citizens from the most important cities in Romania where pollution poses important challenges for the community and for the authorities. The results are useful to public managers in local and central institutions for creating better strategies meant to reduce air pollution, increase air quality, and improve the quality of the citizens’ lives.
“Without Them, I Would Never Have Been Able to Carry on” Levers for the Sustained Employment of Patients with Chronic Inflammatory Arthritis: A French Qualitative Study
Authors: Louati Chaima , Mouelhi Yosra , Kabuth Bernard , Clément Céline
Published: November 2022

Background. Chronic inflammatory arthritis (IA) is known to be involved in declining work outcomes and increased risk of experiencing unemployment. The aim of this study is to qualitatively identify the levers for the employment of patients with IA and AI-like conditions. Methods. To accomplish this task, a multi-centered, exploratory qualitative design involving one-on-one semi-directed interviews and a focus group was performed among 18 IA French patients to deepen our understanding of what enables patients to maintain employment despite the limiting, chronic, and expanding nature of their symptoms. Results. Analysis revealed five clusters of levers for the employment of chronic IA patients: The first cluster of levers was based on a set of verbatim records mentioning an overall improvement in the management of the disease. The second cluster of levers was based on a set of verbatim records mentioning the perceived added value of one’s occupation at a personal, familial, or societal scale. The third cluster of levers was based on a set of verbatim records mentioning the perceived interpersonal supportiveness of the professional sphere. The fourth cluster of levers was based on a set of verbatim records mentioning the micro-, meso-, and macro-characteristics of the working environment. The fifth cluster of levers was based on a set of verbatim records mentioning intrapersonal attributes. Conclusions. This study deepens and updates the current knowledge on what empowers patients dealing with chronic AI. These results provide valuable insights for stakeholders involved in designing or deploying employment initiatives for patients with AI.
Hydrodynamic Modelling and Flood Risk Analysis of Urban Catchments under Multiple Scenarios: A Case Study of Dongfeng Canal District, Zhengzhou
Authors: Wei Huaibin , Zhang Liyuan , Liu Jing
Published: November 2022

In recent years, urban flooding has become an increasingly serious problem, posing a serious threat to socio-economic development and personal safety. In this paper, we consider the Dongfeng Canal area in Zhengzhou City as an example and build a 1D/2D coupled urban flood model using the InfoWorks ICM. This study area uses six scenarios with rainfall return periods of 5 a, 20 a, and 50 a, corresponding to rainfall ephemeris of 1 h and 2 h to assess the flood risk. The results of the study show that (1) The flood depth, inundation duration, and extent of inundation in the study area vary with the return period and rainfall history. Generally, most of the water accumulation is concentrated in the low-lying areas adjacent to the river and near the roadbed. (2) As the rainfall recurrence period and rainfall duration increase, the proportion of overflow at the nodes becomes more pronounced and the overload from the pipe network flows mainly to the overload. (3) The high-risk areas under the different scenarios are mainly distributed on both sides of the river, and most of the low-risk areas transform into medium- and high-risk areas as the rainfall recurrence period and rainfall duration increase. This study analyses the flood risk situation under different scenarios, as well as the elements and areas that should be monitored in case of flooding, with the aim of providing a reference for flood prevention and control in the study area and formulating corresponding countermeasures. It also serves as a reference for flood risk analysis in other areas with similar situations.
Type D Personality and Health Behaviors in People Living with Obesity
Authors: Buczkowska Marta , Górski Michał , Domagalska Joanna , Buczkowski Krzysztof , Nowak Przemysław
Published: November 2022

Background: Considering that health behaviors and personality traits play an important role in the formation of health attitudes, the main objective of this study was to evaluate the relations that occur between type D personality and health behaviors in a group of obese patients. Methods: 443 adult patients with BMI ≥ 30 kg/m2, who had been hospitalized in selected hospital facilities in the Silesian Voivodeship (Poland), participated in the study. Respondents completed three standardized questionnaires—the Multidimensional Health Locus of Control Scale, version A (MHLC-A), the Inventory of Health Behaviors (IZZ), and the Type D Scale (DS-14). Results: Patients with type D personality were characterized by the least effective mental attitudes and preventive behaviors, and differed significantly from the other personality types (intermediate and non-type D). Type D personality increased the risk of initiating improper health behaviors by more than five times. Regarding the sense of health control, patients with type D personality had significantly lower scores for the Internal Dimension subscale (21.3 ± 3.1) and higher for the Powerful Others Dimension subscale (24.0 ± 2.6), compared to patients with intermediate and non-type D personality. Proper health behaviors correlated with an internal sense of health control; the strongest correlation, defined as a medium, was with Preventive Behaviors (R = 0.42; p < 0.0001). Conclusions: Type D personality was associated with poorer attitudes towards health. Among obese respondents with a type D personality, there was a significantly higher prevalence of those who believed that their health status was a consequence of chance events.
The Time-Varying Effect of Participatory Shift Scheduling on Working Hour Characteristics and Sickness Absence: Evidence from a Quasi-Experiment in Hospitals
Authors: Turunen Jarno , Karhula Kati , Ropponen Annina , Koskinen Aki , Shiri Rahman , Sallinen Mikael , Ervasti Jenni , Pehkonen Jaakko , Härmä Mikko
Published: November 2022

Participatory shift scheduling for irregular working hours can influence shift schedules and sickness absence. We investigated the effects of using participatory shift scheduling and shift schedule evaluation tools on working hour characteristics and sickness absence. We utilized a panel data for 2015−2019 with 16,557 hospital employees (6143 in the intervention and 10,345 in the control group). Difference-in-differences regression with ward-level clustered standard errors was used to estimate the average treatment effect on the treated coefficients relative to timing of the intervention with 95% confidence intervals (CI). Using participatory scheduling tool increased long working hours and weekend work and had delayed effects on the short (1–3 days) sickness absences. Increased effects were observed: 0.2 [95% CI 0.0−0.4] days for the second, and 0.8 [95% CI 0.5−1.0] for the third year after the onset of intervention. An average increase of 0.5 [95% CI 0.1−0.9] episodes on all sickness absence episodes was observed for the third year. Using the shift schedule evaluation tool with the participatory shift scheduling tool attenuated the adverse effects. To conclude, participatory shift scheduling increased some potentially harmful working hour characteristics but its effects on sickness absence were negligible, and further attenuated by using the shift schedule evaluation tool.
Reconsidering Tourism Destination Images by Exploring Similarities between Travelogue Texts and Photographs
Authors: Zhang Xin , Lu Xiaoqian , Zhou Xiaolan , Shen Chaohai
Published: November 2022

With the rise of user-generated content (UGC) and deep learning technology, more and more researchers construct and measure the tourism destination image (TDI) through online travelogues. However, due to the impact of COVID-19 prevention and control, the number of online travelogues has decreased significantly and, therefore, the scientific validity of the TDI based only on text or photos has been questioned. This research fills a gap by comparing the differences between visual and semantic images in terms of the overall image perception and image formation through natural language processing technology and image caption technology in obtaining TDIs, taking Tiantai County in Zhejiang Province of China as a case. Our results show that the texts and photographs shared major similarities in the overall TDI, but from the perspective of interest, they reflect differently. Therefore, when considering the data source selection for TDI research with a small number of travelogues, texts should be the main content, supplemented by photographs.
Integrative Analysis of Transcriptome-Wide Association Study and Gene-Based Association Analysis Identifies In Silico Candidate Genes Associated with Juvenile Idiopathic Arthritis
Authors: Liu Shuai , Gong Weiming , Liu Lu , Yan Ran , Wang Shukang , Yuan Zhongshang
Published: November 2022

Genome-wide association study (GWAS) of Juvenile idiopathic arthritis (JIA) suffers from low power due to limited sample size and the interpretation challenge due to most signals located in non-coding regions. Gene-level analysis could alleviate these issues. Using GWAS summary statistics, we performed two typical gene-level analysis of JIA, transcriptome-wide association studies (TWAS) using FUnctional Summary-based ImputatiON (FUSION) and gene-based analysis using eQTL Multi-marker Analysis of GenoMic Annotation (eMAGMA), followed by comprehensive enrichment analysis. Among 33 overlapped significant genes from these two methods, 11 were previously reported, including TYK2 (PFUSION = 5.12 × 10−6, PeMAGMA = 1.94 × 10−7 for whole blood), IL-6R (PFUSION = 8.63 × 10−7, PeMAGMA = 2.74 × 10−6 for cells EBV-transformed lymphocytes), and Fas (PFUSION = 5.21 × 10−5, PeMAGMA = 1.08 × 10−6 for muscle skeletal). Some newly plausible JIA-associated genes are also reported, including IL-27 (PFUSION = 2.10 × 10−7, PeMAGMA = 3.93 × 10−8 for Liver), LAT (PFUSION = 1.53 × 10−4, PeMAGMA = 4.62 × 10−7 for Artery Aorta), and MAGI3 (PFUSION = 1.30 × 10−5, PeMAGMA = 1.73 × 10−7 for Muscle Skeletal). Enrichment analysis further highlighted 4 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and 10 Gene Ontology (GO) terms. Our findings can benefit the understanding of genetic determinants and potential therapeutic targets for JIA.
Deep-Learning Image Stabilization for Adaptive Optics Ophthalmoscopy
Authors: Liu Shudong , Ji Zhenghao , He Yi , Lu Jing , Lan Gongpu , Cong Jia , Xu Xiaoyu , Gu Boyu
Published: November 2022

An adaptive optics scanning laser ophthalmoscope (AOSLO) has the characteristics of a high resolution and a small field of view (FOV), which are greatly affected by eye motion. Continual eye motion will cause distortions both within the frame (intra-frame) and between frames (inter-frame). Overcoming eye motion and achieving image stabilization is the first step and is of great importance in image analysis. Although cross-correlation-based methods enable image registration to be achieved, the manual identification and distinguishing of images with saccades is required; manual registration has a high accuracy, but it is time-consuming and complicated. Some imaging systems are able to compensate for eye motion during the imaging process, but special hardware devices need to be integrated into the system. In this paper, we proposed a deep-learning-based algorithm for automatic image stabilization. The algorithm used the VGG-16 network to extract convolution features and a correlation filter to detect the position of reference in the next frame, and finally, it compensated for displacement to achieve registration. According to the results, the mean difference in the vertical and horizontal displacement between the algorithm and manual registration was 0.07 pixels and 0.16 pixels, respectively, with a 95% confidence interval of (−3.26 px, 3.40 px) and (−4.99 px, 5.30 px). The Pearson correlation coefficients for the vertical and horizontal displacements between these two methods were 0.99 and 0.99, respectively. Compared with cross-correlation-based methods, the algorithm had a higher accuracy, automatically removed images with blinks, and corrected images with saccades. Compared with manual registration, the algorithm enabled manual registration accuracy to be achieved without manual intervention.
Fall Armyworm Infestation and Development: Screening Tropical Maize Genotypes for Resistance in Zambia
Authors: Kasoma Chapwa , Shimelis Hussein , Laing Mark D. , Mekonnen Bethelihem
Published: November 2022

Knowledge of fall armyworm (FAW) (Spodoptera frugiperda J.E. Smith) rearing, infestation and development and precision screening protocols are preconditions for the successful introgression of resistance genes into farmer-preferred varieties. We aimed to determine FAW developmental stages, screen tropical maize and select resistant lines under controlled conditions in Zambia. Field-collected FAW samples constituting 30 egg masses and 60 larvae were reared using maize leaf- and stalk-based and soy- and wheat flour-based diets at 27 ± 1 °C, 60 ± 5% relative humidity and 12 h day length. The resulting neonates were separated into sets A and B. The life cycles of set A and field-collected larvae were monitored to document the FAW developmental features. Set B neonates were used to infest the seedlings of 63 diverse tropical maize genotypes. Egg, larva, pupa and adult stages had mean durations of 2, 24, 20 and 12 days, respectively. Test maize genotypes revealed significant differences (p < 0.05) based on FAW reaction types, with lines TL13159, TL02562, TL142151, VL050120 and CML548-B exhibiting resistance reactions, while CML545-B, CZL1310c, CZL16095, EBL169550, ZM4236 and Pool 16 displayed moderate resistance. These genotypes are candidate sources of FAW resistance for further breeding. This study will facilitate controlled FAW rearing for host screening in the integration of FAW resistance into market-preferred maize lines.
Effects of Elevated CO2 Concentration on Host Adaptability and Chlorantraniliprole Susceptibility in Spodoptera frugiperda
Authors: Lu Zhihui , Sun Zhongxiang , Li Yahong , Hao Ruoshi , Chen Yaping , Chen Bin , Qin Xiaoping , Tao Xuan , Gui Furong
Published: November 2022

Elevated atmospheric carbon dioxide concentrations (eCO2) can affect both herbivorous insects and their host plants. The fall armyworm (FAW), Spodoptera frugiperda, is a highly polyphagous agricultural pest that may attack more than 350 host plant species and has developed resistance to both conventional and novel-action insecticides. However, the effects of eCO2 on host adaptability and insecticide resistance of FAW are unclear. We hypothesized that eCO2 might affect insecticide resistance of FAW by affecting its host plants. To test this hypothesis, we investigated the effect of eCO2 on (1) FAW’s susceptibility to chlorantraniliprole after feeding on wheat, (2) FAW’s population performance traits (including the growth and reproduction), and (3) changes in gene expression in the FAW by transcriptome sequencing. The toxicity of chlorantraniliprole against the FAW under eCO2 (800 µL/L) stress showed that the LC50 values were 2.40, 2.06, and 1.46 times the values at the ambient CO2 concentration (400 µL/L, aCO2) for the three generations, respectively. Under eCO2, the life span of pupae and adults and the total number of generations were significantly shorter than the FAW under aCO2. Compared to the aCO2 treatment, the weights of the 3rd and 4th instar larvae and pupae of FAW under eCO2 were significantly heavier. Transcriptome sequencing results showed that more than 79 detoxification enzyme genes in FAW were upregulated under eCO2 treatment, including 40 P450, 5 CarE, 17 ABC, and 7 UGT genes. Our results showed that eCO2 increased the population performance of FAW on wheat and reduced its susceptibility to chlorantraniliprole by inducing the expression of detoxification enzyme genes. This study has important implications for assessing the damage of FAW in the future under the environment of increasing atmospheric CO2 concentration.
Clinical Evaluation of Non-Contrast-Enhanced Radial Quiescent-Interval Slice-Selective (QISS) Magnetic Resonance Angiography in Comparison to Contrast-Enhanced Computed Tomography Angiography for the Evaluation of Endoleaks after Abdominal Endovascular Aneurysm Repair
Authors: Mostafa Karim , Pfarr Julian , Langguth Patrick , Schäfer Jost Philipp , Trentmann Jens , Koktzoglou Ioannis , Edelman Robert R. , Bueno Neves Fernando , Graessner Joachim , Both Marcus , Jansen Olav , Salehi Ravesh Mona
Published: November 2022

Purpose. Contrast-enhanced (CE) angiographic techniques, such as computed tomographic angiography (CE-CTA), are most commonly used for follow-up imaging after endovascular aneurysm repair. In this study, CE-CTA and non-CE QISS-MRA were compared for the first time for assessing endoleaks and aneurysms at follow-up after abdominal EVAR. Methods. Our study included 20 patients (17 male, median age 79.8 years) who underwent radial QISS-MRA and CE-CTA after EVAR at their first follow-up examination. Two interventional radiologists evaluated datasets from both techniques in each patient concerning presence of endoleaks, types of endoleaks, aneurysm diameter, and image quality. Interobserver and intermodal agreement were assessed with Cohen’s Kappa. Results. Image quality was rated as excellent or good for both modalities by both observers. Ferromagnetic embolization materials cause hyperdense artifacts in CE-CTA causing aneurysm sac diameter measurements to be inaccurate by up to 1 cm. Type 2 endoleaks with low-flow characteristics in CE-CTA were overlooked compared to radial QISS-MRA. Compared to CE-CTA, all endoleaks after abdominal EVAR were detected and classified correctly on QISS-MRA. The interobserver agreement between CE-CTA and QISS-MRA was almost perfect, except for type 2 endoleaks, where agreement was substantial. Intermodal aneurysm diameter correlate “very strongly” for both observers. Conclusions. Radial QISS-MRA is a contrast agent free technique for diagnosing and monitoring all types of endoleaks and aneurysms in patients after abdominal EVAR. It provides information about specific clinical questions concerning aneurysm diameter and presence and types of endoleaks without radiation exposure and the side effects associated with iodine-based contrast agents.
Risk Factors Affecting Development and Persistence of Preschool Wheezing: Consensus Document of the Emilia-Romagna Asthma (ERA) Study Group
Authors: Grandinetti Roberto , Fainardi Valentina , Caffarelli Carlo , Capoferri Gaia , Lazzara Angela , Tornesello Marco , Meoli Aniello , Bergamini Barbara Maria , Bertelli Luca , Biserna Loretta , Bottau Paolo , Corinaldesi Elena , De Paulis Nicoletta , Dondi Arianna , Guidi Battista , Lombardi Francesca , Magistrali Maria Sole , Marastoni Elisabetta , Pastorelli Silvia , Piccorossi Alessandra , Poloni Maurizio , Tagliati Sylvie , Vaienti Francesca , Gregori Giuseppe , Sacchetti Roberto , Mari Sandra , Musetti Manuela , Antodaro Francesco , Bergomi Andrea , Reggiani Lamberto , Caramelli Fabio , De Fanti Alessandro , Marchetti Federico , Ricci Giampaolo , Esposito Susanna ,   on behalf of the Emilia-Romagna Asthma (ERA) Study Group
Published: November 2022

Wheezing at preschool age (i.e., before the age of six) is common, occurring in about 30% of children before the age of three. In terms of health care burden, preschool children with wheeze show double the rate of access to the emergency department and five times the rate of hospital admissions compared with school-age asthmatics. The consensus document aims to analyse the underlying mechanisms involved in the pathogenesis of preschool wheezing and define the risk factors (i.e., allergy, atopy, infection, bronchiolitis, genetics, indoor and outdoor pollution, tobacco smoke exposure, obesity, prematurity) and the protective factors (i.e., probiotics, breastfeeding, vitamin D, influenza vaccination, non-specific immunomodulators) associated with the development of the disease in the young child. A multidisciplinary panel of experts from the Emilia-Romagna Region, Italy, addressed twelve key questions regarding managing preschool wheezing. Clinical questions have been formulated by the expert panel using the PICO format (Patients, Intervention, Comparison, Outcomes). Systematic reviews have been conducted on PubMed to answer these specific questions and formulate recommendations. The GRADE approach has been used for each selected paper to assess the quality of the evidence and the degree of recommendations. Based on a panel of experts and extensive updated literature, this consensus document provides insight into the pathogenesis, risk and protective factors associated with the development and persistence of preschool wheezing. Undoubtedly, more research is needed to improve our understanding of the disease and confirm the associations between certain factors and the risk of wheezing in early life. In addition, preventive strategies must be promoted to avoid children’s exposure to risk factors that may permanently affect respiratory health.
No Significant Differences in Clinical and Radiographic Outcomes between PCL Retained or Sacrificed Kinematic Aligned Medial Pivot Total Knee Arthroplasty in Varus Knee
Authors: Giustra Fortunato , Bosco Francesco , Cacciola Giorgio , Risitano Salvatore , Capella Marcello , Bistolfi Alessandro , Massè Alessandro , Sabatini Luigi
Published: November 2022

In the last decades, several surgical techniques, such as medial pivot (MP) philosophy and kinematic alignment (KA), have been introduced in total knee arthroplasty (TKA) to improve patients’ outcomes. This retrospective study aims to evaluate the clinical, radiographic, and functional results of PCL preservation or sacrifice in KA MP-TKA. A consecutive series of 147 patients older than 60, with a minimum follow-up of two years, were treated with TKA for severe primary knee osteoarthritis (OA) at the Department of Orthopedics and Traumatology between 1 January 2019, and 1 July 2020. After excluding those not meeting the inclusion criteria, 64 patients were included in the study analysis. Regarding radiographic outcomes, no statistically significant difference was observed between patients with preserved or sacrificed PCL (p > 0.05). A slight improvement in Knee Society Score (KSS), knee and function score, and FJS was observed for the PCL-preserved group, although this superiority tendency was not statistically significant (p > 0.05). PCL-preserved MA MP-TKA reported a statistically significant result in only two questions on the FJS questionnaire (p < 0.05). A slight, non-statistically significant improvement in active ROM was found in the PCL-sacrificed group (p > 0.05). No interventions or revisions were reported in this case series for all treated patients at the final follow-up. No significant differences were described in clinical, radiographic, and functional outcomes in preserved or sacrificed PCL KA MP-TKA. Although not significant, a slight trend toward better clinical outcomes was reported in PCL-preserved KA MP-TKA.
Neurologic Urinary Incontinence, Lower Urinary Tract Symptoms and Sexual Dysfunctions in Multiple Sclerosis: Expert Opinions Based on the Review of Current Evidences
Authors: Bientinesi Riccardo , Gavi Filippo , Coluzzi Simone , Nociti Viviana , Marturano Monia , Sacco Emilio
Published: November 2022

Objective: To resume each specialist’s role in the management of neurologic urinary tract symptoms (nLUTS) and sexual dysfunctions (SD) in patients suffering from multiple sclerosis (MS). Material and Methods: We asked a neurologist, a urologist and a gynecologist, experts on neuro-urology and sexual dysfunction at our hospital, to resume their role in the management of nLUTS and SD in MS patients based on the review of current evidence. PubMed was used to review literature with a focus on nLUTS and SD in MS patients. Conclusions: The difference in symptomatology in MS patients is very wide. The more the CNS is involved, the more the variations and severity of nLUTS is present. SD have numerous causes and should always be assessed. Urologists play the director’s role in evaluating and treating these patients. Neurologist should play an important role, they must evaluate the potential mutual interactions between disease manifestations of MS and their treatments. Additionally, gynecologists play an important information sharing role in the management of patients with multiple sclerosis.
Iris Racemose Hemangioma Assessment with Swept Source Optical Coherence Tomography Angiography: A Feasibility Study and Stand-Alone Comparison
Authors: Confalonieri Filippo , Ngo Huy Bao , Petersen Helga Halldorsdottir , Eide Nils Andreas , Petrovski Goran
Published: November 2022

Purpose: To evaluate arteriovenous malformations (AVM) with swept-source (SS) optical coherence tomography (OCT) angiography (OCTA) in iris racemose hemangioma and compare it with traditional intravenous iris fluorescein angiography (IVFA). Methods: A cross-sectional observational clinical study was conducted on patients with iris racemose hemangioma with the ZEISS PLEX Elite 9000 SS OCT & OCTA. Results: Three eyes of three patients were imaged. Iris racemose hemangiomas demonstrated a tortuous, well-defined, and continuous course of the AVM. The ZEISS PLEX Elite 9000 SS OCT & OCTA allowed for a detailed visualization of the ARM and was superior to IVFA in depicting small caliber, fine vessels. Conclusions: SS-OCTA may provide a dye-free, no-injection, cost-effective method comparable to spectral domain OCTA and IVFA for diagnosing and monitoring iris racemose hemangiomas for growth and vascularity.
PSMA Expression in Solid Tumors beyond the Prostate Gland: Ready for Theranostic Applications?
Authors: Lauri Chiara , Chiurchioni Lorenzo , Russo Vincenzo Marcello , Zannini Luca , Signore Alberto
Published: November 2022

In the past decades, the expanding use of prostate-specific membrane antigen (PSMA) imaging for prostate cancer has led to the incidental detection of a lot of extra-prostatic malignancies showing an increased uptake of PSMA. Due to these incidental findings, the increasing amount of immunohistochemistry studies and the deeper knowledge of the mechanisms of expression of this antigen, it is now clear that “PSMA” is a misnomer, since it is not specific to the prostate gland. Nevertheless, this lack of specificity could represent an interesting opportunity to bring new insights on the biology of PSMA and its sites of expression to image and treat new conditions, particularly several cancers. In this review, we will describe the main extra-prostatic cancers that exhibit PSMA expression and that can be studied with PSMA-based positron emission tomography–computed tomography (PET/CT) as an additional or alternative tool to conventional imaging. In particular, we will focus on cancers in which a radioligand therapy with 177lutetium has been attempted, aiming to provide an overview of the possible future theragnostic applications of PSMA.