bluuebunny/crossref_metadata_2025 huggingface dataset:
A Review on Coumarin Derivatives as Potent Anti-tuberculosis Agents
Authors: Singh Kuldeep , Mujeeb Samar , Yogi Bhumika , Ansari Vaseem , Sinha Shweta
Published: September 2021

Background:

Tuberculosis (TB) is an acute or chronic infectious disease caused by several species of Mycobacterium, collectively called tubercle bacilli or Mycobacterium tuberculosis complex. Around 10 million people get sick with tuberculosis (TB) each year. TB is the second leading cause of death today after HIV/AIDS. A serious problem in the context of MDR-TB is the extensively drug-resistant TB, which is an important reason for the restricted chemotherapy in TB. Therefore, there is a need to explore new antitubercular (anti-TB) agents. Coumarin is an oxygencontaining heterocyclic compound and can be widely found in many natural products, and many of them display diverse biological activities. The wide spectrum of activities of coumarin molecules has intrigued the scientists to explore the natural coumarins and their synthetic derivatives for their potential as anti-TB drugs.

Objective:

The objective of this review is to emphasize important coumarin analogs with anti-TB activities and their structure-activity relationships (SAR) for designing better anti-TB agents.

Method:

Latest, authentic and published reports on various synthetic and natural coumarin derivatives and their anti-TB activities is being thoroughly studied and analyzed. The structural requirements of coumarins as anti-TB drugs have also been studied.

Results:

Collection and compilation of reports on various synthetic and natural coumarin derivatives and their anti-TB activities are being performed.

Conclusion:

The study provides the latest report on coumarin derivatives synthesized as anti-TB agent and whether their activity depends on structural changes or not.
The Role of Estonian Community Settings for Achieving Independent Living for Persons with Disabilities in Eastern European Countries
Authors: Mammadov Vugar
Published: September 2021

This article is dedicated to analysing the implementation of Article 19 (paragraphs ‘b’ and ‘c’) of the Convention on the Rights of Persons with Disabilities (hereby: the CRPD) in community settings in Estonia and how Estonian experiences can shift the development of independent living and deinstitutionalization in other non-European Union member countries of Eastern Europe. In this regard, this article depicts the details of independent living for persons with mental health problems according to the UN CRPD Committee. Furthermore, the introduction of Maarja Küla (village) SA and its role in providing independent living has been highlighted as well. Finally, the primary obstacles in Eastern European countries ahead of establishing an independent living as well as solutions for the implementation of Article 19 are underlined, and as an author, I have emphasized how to foster deinstitutionalization in the conclusion.

In most congregated community settings where organizational management techniques have relied on the medical model of disability rather than the social model of disability, inhabitants suffer from legal incapacitation in most cases. These community settings had been established before the adoption of the CRPD, but gradually have been developed and adjusted to the fundamental principles of the Convention. In my view, a human rights approach has been emerging in such places, though the UN CRPD Committee has urged to rectify management methods and to promote the social model of disability. 

This research paper also aims to describe the current situation in community settings that has arisen following the pandemic and to find out scientific and practical solutions to abolish the remaining elements of the medical model of disability and to substitute the human rights approach towards a social model of disability in the management and philosophical views of community settings for persons with disabilities.
Multilateral Investment Court – a Cure for Investor-State Disputes Under Extra-EU International Investment Agreements?
Authors: Zwolankiewicz Agata
Published: September 2021

Both branches of international economic law – international investment and trade law are currently in crisis. Many reforms have been proposed to cure the shortcomings of their dispute resolution mechanisms. Distinctive though they are, it seems that the newest EU’s proposal to establish the Multilateral Investment Court is heavily inspired by the dispute settlement system which exists in the World Trade Organization. The new system has been introduced to replace the investor-State dispute settlement mechanism existing in most investment treaties. In this article, the author assesses the objectives of the reform through the prism of successes and failures of the WTO dispute settlement system.
Multicultural heritage as a basis for sustainable development of urban tourism in Warsaw – COVID-19 pandemic time
Authors: Ostrowska-Tryzno Anna , Pawlikowska-Piechotka Anna
Published: September 2021

Introduction: The importance of multiculturalism for the development of tourism, consistently emphasized in the literature, shows the long history and rich tradition of this form of tourism. Poland has historically been a land of transition between East and West, a land where different cultures have existed side by side: German, Jewish, Polish, and Russian. For centuries Poland was a meeting place of different religions and cultures and today’s landscape still shows evidence of this. The catastrophe of World War II brought the annihilation of a multicultural society and created a homogeneity, unprecedented in our history. Jewish heritage and urban cultural tourism: In their almost 2000-year diaspora, Jews have been present in Poland for eight hundred years: from the early middle ages until the Holocaust, the annihilation during World War II. The Jews were distinguished from other community groups by their religion, language, customs, art and architecture. In the interwar period of the 20th century, Poland was home to the largest Jewish community in Europe, distinguished by its enormous cultural and intellectual vitality. Pandemic time: The outbreak of the COVID-19 pandemic has hit the tourism sector hard, and travel restrictions still apply to us. Therefore, it is necessary to verify the forecasts and prepare new recommendations for cultural tourism destinations during and after the pandemic. Conclusions: Recently there has been a revival of interests in Jewish heritage and many tourists (both domestic and foreign) want to explore Jewish culture and remaining monuments of the past. Despite pandemic time restrictions it is also possible, however new actions and policy are required to secure sanitary recommendations and rebuild consumer confidence.
Mitologia grega e psicologia arquetípica
Authors: Macdonald Yedda Raynsford
Published: September 2021

Este artigo analisou os ecos e reflexos simbólicos da pandemia, à luz da psicologia analítica e da psicologia arquetípica e entrelaçando os conceitos de unus mundus, animismo e de perspectiva imaginal com os mitos gregos. A partir das histórias de Eco, Narciso, Ártemis, Héstia, Hermes e Pan, o artigo discutiu os ecos e reflexos da pandemia em uma sociedade narcisista, em uma era de medos generalizados e pânico, com a deterioração do meio ambiente, o uso excessivo de redes sociais e da tecnologia, a necessidade de isolamento social e de retorno à casa. O trabalho também abordou o que os gregos chamavam de hybris – a soberba humana de se acreditar acima dos deuses – como mal de uma era desconectada do coletivo e da natureza. Por fim, o artigo destaca a importância de uma educação para ver e compreender as imagens internas e externas e propõe um fazer alma como parte da recuperação da alma do mundo.
Methods of Mining User-Generated Online Substance Use Data: A Scoping Review (Preprint)
Authors: Ahmed Rehan , Moazzami Kia , Paknys Michael , Beazely Michael
Published: September 2021

BACKGROUND

Social media and online discussion forums offer a unique data source for medical and public health research. Using these platforms, people who use drugs often discuss valuable information including adverse effects, formulations, and reasons for use.

OBJECTIVE

Since this data is often unstructured, text and data mining methods are required to extract and analyze these posts systematically. This scoping review summarizes the literature on text and data mining methods for online substance use content.

METHODS

Online databases including PubMed and EMBASE were searched to identify articles meeting the eligibility criteria. Titles and abstracts were first screened by two reviewers and any conflicts were resolved with discussion. Data extraction was performed by two reviewers using an identical template to record information. Any disagreements were resolved with discussion.

RESULTS

The search identified 1131 articles, 26 of which were included for data extraction. Most articles presented unique data mining methods. The five most common strategies included sentiment analysis, topic modeling, data classification, clustering, and association learning.

CONCLUSIONS

Data mining offers a valuable avenue for retrieving useful information from online discussion forums to supplement conventional data sources in medical and public health research. With respect to substance use content, association learning and regression analysis were particularly well-suited for analyzing this data. Future research should focus on confirming the validity and reliability of these data mining methods, while establishing links between data mining, clinical evaluation, and knowledge translation.
Автоматизированный поиск наночастиц на изображениях зондовой микроскопии с использованием нейронной сети
Authors: Синицына О.В. , Воробьев М.М. , Яминский И.В.
Published: September 2021

Использование автоматизированного поиска объектов в зондовой микроскопии дает ряд серьезных преимуществ: высокую скорость обработки данных, минимизацию влияния экспериментатора на процесс измерений, возможность увеличить объем данных, используемых для анализа. В данной работе на примере данных атомно-силовой микроскопии белковых наночастиц мы показали, что для поиска наночастиц, размеры которых сравнимы с уровнем шума, более точный результат дает алгоритм с использованием нейронной сети, тогда как более крупные наночастицы более точно выделяет пороговый алгоритм.
Новое решение для бионаноскопии на основе технологии оптических микролинз
Authors: Яминский И.В. , Ахметова А.И. , Сенотрусова С.А. , Ван З. , Бинг Ю. , Лукьянчук Б.С. , Бармина Е.В. , Симакин А.В. , Шафеев Г.А.
Published: September 2021

Микролинзовая микроскопия – это относительно новое и многообещающее решение для преодоления дифракционного предела в оптической микроскопии. Благодаря использованию сфер из титаната бария возможно получение оптических изображений с разрешением в десятки нанометров. Совмещенная зондовая и микролинзовая микроскопия позволяет осуществлять регистрацию широкого спектра физических и биохимических параметров изучаемых образцов. Существенным достоинством метода является возможность наблюдения биоматерии как с использованием меток и маркеров, а также, что очень существенно, и без них. Это недостижимо для многих других традиционных методов исследования. Использование лазера на парах меди в оптической установке дает возможность исследовать биологические объекты с низкой интенсивностью света.
Эволюция радиационного поведения субмикроэлектронных устройств при снижении проектных норм и особенности развития инфраструктуры испытаний и исследований
Authors: Никифоров А.Ю. , Горбунов М.С. , Смолин А.А. , Бойченко Д.В. , Давыдов Г.Г.
Published: September 2021

В аналитическом обзоре рассмотрены особенности радиационного поведения современных субмикронных микроэлектронных приборов при снижении проектных норм, а также перспективы развития обеспечивающей инфраструктуры для радиационных испытаний.
"АРМИЯ-2021": В ЦЕНТРЕ ВНИМАНИЯ − ДИВЕРСИФИКАЦИЯ
Authors: Набоких Л. , Попов С.
Published: September 2021

Одной из основных тем состоявшегося 23–28 августа 2021 года Международного военно-технического форума "АРМИЯ-2021", организованного Министерством обороны России, стала диверсификация предприятий оборонно-производственного комплекса. На многих стендах сопровождавшей форум масштабной выставки можно было познакомиться с оборудованием и решениями не только военного и двойного, но и гражданского назначения, в том числе телекоммуникационными.
"ЭЛЕКТРОПРОВОД": ПРАЗДНИК ОСОБОГО ЗНАЧЕНИЯ
Authors: Павлова Л.
Published: September 2021

Любое упоминание об этом заводе неизбежно сочетается с определением "особый". Здесь все особое – его истоки, продукция и, конечно же, его люди, создающие особую атмосферу коллективной жизни. Даже, казалось бы, проходное по меркам 236-летней истории завода мероприятие, посвященное завершению строительства здания второго производственного корпуса завода, приуроченное к 10-летию начала строительства первого цеха здесь же, в г. Подольск Московской области, стало особой вехой жизни этого уникального предприятия.
Existence of solutions of boundary value problems for nonlinear fractional differential equations with integral conditions
Authors: Boukehila Ahcene
Published: September 2021

In this work we investigate the existence and uniqueness of solutions of boundary value problems for fractional differential equations involving the Caputo fractional derivative with integral conditions and the nonlinear term depends on the fractional derivative of an unknown function. Our existence results are based on Banach contraction principle and Schauder fixed point theorem. Two examples are provided to illustrate our results.
Uso de la prueba de aliento con 13C-glucosa para evaluar la adherencia al tratamiento en ensayos de intervención nutricional
Authors: García-Rojas Vanessa , Maldonado-Hernández Jorge , Mora-Escobedo Rosalva , Izquierdo-Montalvo Georgina , Verma Mahendra P. , Aragón-Aguilar Alfonso , Ángel-Serrato Dominic , Encarnación-Fernández Jorge Saúl , San Martín-Martínez Eduardo
Published: September 2021

Objetivo: Validar el uso de la prueba de aliento con 13C-glucosa para evaluar la adherencia a un tratamiento nutricional. Métodos: Se realizó una prueba piloto, con once adultos, que ingirieron una botana compuesta de soya/almidón de maíz y enriquecida con U-13C-glucosa. Los participantes se dividieron en tres grupos de estudio y consumieron la botana en diferentes períodos de tiempo durante dos semanas (A=14 días, B=10 días, C=6 días). Diariamente se colectaron muestras de aliento para analizar los valores de δ13C, mediante espectrometría de masas de relaciones isotópicas. Resultados: la mediana del AUC (área bajo la curva) de los valores de δ13C del grupo A fue mayor comparada con la del grupo C (p = 0.029); por otro lado, se encontraron diferencias significativas al combinar los grupos (medianas A y B) y ser comparados con el grupo C (p = 0.038). Finalmente, se encontró una asociación negativa entre los valores de AUC δ13C y la intensidad del tratamiento (rho de Spearman = -0,708; p = 0,015). Se pudo establecer un punto de corte ≤ 3,78, para identificar a los sujetos que cumplieron con menos del 70% del tratamiento, con un 100% de especificidad y un 86% de sensibilidad. Conclusiones: La prueba de aliento con 13C-glucosa, sugiere un buen rendimiento diagnóstico para evaluar la adherencia al tratamiento.
Algoritmo para el análisis temático de documentos digitales
Authors: Polo Bautista Luis Roberto , Martínez Acevedo Karen Vanessa
Published: September 2021

El objetivo del artículo es presentar un algoritmo para asignar áreas temáticas a documentos digitales que sirva como herramienta de apoyo al análisis temático dentro de la organización de la información, con el fin de ser implementado en el desarrollo de vocabularios controlados. La metodología utilizada consistió en aplicar el Reconocimiento Óptico de Caracteres (ROC) y la Asignación Latente de Dirichlet (ALD) como las principales herramientas para el desarrollo de un algoritmo basado en el lenguaje de programación Python, que permite la lectura de archivos con extensión PDF para la obtención de los principales temas del corpus textual. Los resultados de la aplicación del algoritmo demuestran su utilidad en el área de la indización como un sistema para identificar y extraer temas relevantes de un documento específico en formato electrónico, permitiendo la automatización de procesos por parte del profesional de la información. De esta forma, se concluye su uso como desarrollo de puntos de acceso alternativos en función del contenido de los textos.
Recommendation System for Voters using Classifier Rule
Authors: Patil Sarita
Published: September 2021

Abstract: Recommender System gives suggestions based on the user’s preferences and features of items. Ultimately its performance and efficiency depends on these factors and their representations. It also reduces the uncertainties by displaying item features. Here fuzzy logic in the recommendation system plays vital role to handle uncertainty. Fuzzy logic helps the user to provide most proper information related to the model. The multiple opinions from the user are taken on the basis of Voters database to take appropriate decision. In the proposed system classification of the database is done with the help of rules of decision tree and PART in which all the attributes are included whichever given. Comparison between these proves that PART works more efficiently than that of rules of decision tree. Keywords: Recommendation system for voters, Rules of decision tree, PART
Image Colorization Using Autoencoders
Authors: Nihalaani Rachaell
Published: September 2021

Abstract: Modification of art may be viewed as enhancement or vandalization. Even though for a long time many were opposed to the idea of colorizing images, they now have finally viewed it for what it is - an enhancement of the art form. Grayscale image colorization has since been a long-standing artistic division. It has been used to revive or modify images taken prior to the invention of colour photography. This paper explores one method to reinvigorate grayscale images by colorizing them. We propose the use of deep learning, specifically the use of convolution neural networks. The obtained results show the ability of our model to realistically colorize grayscale images. Keywords: Deep Learning, Convolutional Neural Network, Image Colorization, Autoencoders.
Employee Attrition Dashboard Using Tableau
Authors: Sanjana Kovuri
Published: September 2021

Abstract: Tableau is a powerful and fastest growing data visualization tool used in the Business Intelligence Industry. It helps in simplifying raw data in a very easily understandable format. It also allows non-technical users to create customized dashboards. The purpose of this paper is to visualize and analyse the employee attrition rate using the Tableau visualization tool by considering various important factors that play crucial role in affecting the attrition rate. In order to visualize and predict the attrition rate of employees of an organization, we proposed an intelligent, flexible and effective system that helps the managers to identify the valuable employee and try to retain them. The attrition rate can be analysed based on various factors such as job roles, years since last promotion, gender and number of companies worked. Keywords: Employee Attrition, Tableau, Attrition Analysis, Visualization, Employee Turnover, Dashboards
Structural damage at Florida Cando Complex – An Overview
Authors: Khan Mohd Muneeruddin
Published: September 2021

Abstract: In this paper the structural damage at Florida complex is being discussed. Inspite of an early report by engineering consultant, giving evidence of possible structural damage and necessity of repairs required, the delay in repair works resulted in a catastrophic collapse of the building in the middle of the night. The study on this collapse of the building opens the discussion on timely actions to be taken during the construction as well as maintenance of the buildings. Keywords: Structural damage, collapse, deteriorating, repair, corrosion, water seepage.
Prophylactic Role of Mandukasan and OM Chanting Patients Who Survives with Diabetes
Authors: Menariya Ramkanya , Singh Harshwardhan , Tank Parmesh , Menaria Jeevan
Published: September 2021

Diabetes Mellitus is one of the most chronic non-communicable diseases in the enire world. Yoga is an part of Indian culture which doing ancient times by our rishi munis. Nowadays science has been considered yoga for management of various diseases i.e. hypertension, diabetes, asthma. In this case study had been conducted to understand effect of yoga in type 2 diabetics.  Yoga group were put through mandukasanasana and mandukasan with OM chanting for 40 days. Biochemical parameters was performed i.e. FBG, PPBG and HbA1C. It can be concluded that mandukasan with OM chanting has been helpful as an adjunct to medical therapy to minimize the biochemical parameters. Yoga therapy helpful for the status of diabetics in terms of reduction of drug doses, physical and mental alertness and prevention of various complications related to diabetes.

Keywords: Mandukasan, OM Chanting, Diabetes
Date Powder as Alternative Carbone Source in Optimizing the Cultivation of (Bacillus megaterium) in Submerged State Fermentation
Authors: Al-Taweil Hayyan I , Aldawood Yahya , Alhamal Heba
Published: September 2021

Problems statement: A study had shown a strain of Bacillus megaterium was isolated from the soil. Questions were whether date powder could be used as alternatives of carbon sources for Bacillus megaterium submerged state cultivation?

Approach: To evaluate  the effects of the using date powder; The fermentation was carried out in shake flasks using a complex medium consisting of (g/L) ammonium tartrate, 2.0; magnesium sulphateheptahydrate, 4.0; dipotassium phosphate, 14.0; calcium chloride, 0.2, NaHPO4, 4.0, yeast extract, 3.0, trace elements, 2.0ml and glucose 6.0(4.0, yeast extract, 3.0, trace elements, 2.0ml and glucose 6.0) were replaced by dates powder at three rates; 5,10 and15 g/L

Results show that the rate of production of biomass during submerged fermentation by Bacillus megaterium at 30±1°C for 24 hours of incubation using date powder was maximizes between 18 and 24 hr of fermentation. The experimental runs and results for the Box– Behnken design. The 15 runs in a single block were used to study the effects using date powder in different rates on one response. Biomass concentration ranged from 6.5cfu /l to 12.9cfu /.comparing with 14.8 cfu/ g for the commercial growth media. The ANOVA tables give the statistical significance of the effects for biomass. These effects were dates powder rates, the optimized growth medium with pH 7, inoculums’ size 106, temp 24oC and moisture dates powder 15 g/L. The biomass concentrations obtained under the optimal conditions 12.9cfu/l.

Key words: Date Powders, Fermentation, Bacillus megaterium, biomass, Submerged State
Capsule Formulation Essay of Herbal Extracts of Trunk Bark of Anogeissus leiocarpus (DC) Guill. Et Perr. (Combretaceae) for the Treatment of Hypertension
Authors: OUEDRAOGO Salfo , Sombie C. Bavouma , Diawara Zime Hermine , Yameogo B.G. Josias , TRAORE Tata Kadiatou , Nitiema Mathieu , Belemnaba Lazare , Ouedraogo Sylvin , Semde Rasmané
Published: September 2021

Introduction: The trunks barks of Anogeissus leiocarpus contains multiple antihypertensive components and are, therefore, widely used for the treatment of hypertension.

Objective: This study aimed to formulate capsules containing a freeze-dried aqueous extract of the trunk’s barks.

Methodology: Three (03) capsule formulations were prepared using wet granulation from lyophilised aqueous extract of Anogeissus leiocarpus trunk bark, with different proportions of excipients including Corn starch used as the diluent, Polyvinylpyrrolidone K25 (PVP) used as binding agent and Magnesium stearate used as gliding agents. The filling of capsules was done using a semi-automatic capsule filler with empty capsules of size 3. The flow properties of the granules and the quality control were performed according to the European Pharmacopoeia 10th ed.

Results/Discussion: All granules had good flow properties, and the F1 and F3 formulations had the best pharmaceutics characteristics according to the recommendations of the European Pharmacopoeia 10th ed. The mean levels of phenolic tracers were 0.039±0.0097 mg gallic acid equivalent per capsule (GAE/capsule) for the F1 formulation and 0.059±0.0063 mg GAE/capsule for the F3 formulation.

Conclusion: This study allowed the galenic formulation of capsules based on extracts of good characteristic quality for the treatment of hypertension.

Keywords: Anogeissus leiocarpus, extract, excipients, formulations, capsule
Formulation and Evaluation of Aceclofenac Liposomes
Authors: Kaur Gurleen , Naaz Zaquiyya , Kumar Kapil , Teotia Deepak
Published: September 2021

Patients who suffered from rheumatic disease and osteoarthritis are generally prescribed the non-steroidal anti-inflammatory drug (NSAIDs). Osteoarthritis is a common musculoskeletal disorder, which impairs body function and acts as an economic burden. Due to the repetitive use of ACE by oral route, it may cause gastrointestinal complications such as ulceration, bleeding, pain, perforation. To decrease the side effects of ACE, it is given by topical route in the form of ointment. This review highlights reducing gastrointestinal problems and promotes the safety and efficacy of the ACE. The Aceclofenac liposomes were prepared by the thin film hydration technique and evaluated by various methods such as in- vitro release study, % yield, drug entrapment efficiency, pH of the prepared formulation. The prepared system was also characterized by Fourier transform infra-red spectrophotometer to identify the drug- excipients interaction. The maximum entrapment efficiency of liposomes was found to be 90%. The main aim of this study was to develop and characterized a vesicular drug carrier system for topical delivery of Aceclofenac to overcome the problem related with oral route.

Keywords: Liposomes, Aceclofenac, topical delivery, transdermal delivery, rheumatic disease and osteoarthritis
Antimicrobial Susceptibility Sensitivity Pattern in Positive Urine Culture for Urinary Tract Pathogens from Tertiary Care Hospital
Authors: John Sahana , Mahesh Agasa Ramu
Published: September 2021

Hospital specific monitoring studies aims to determine the prevalence of the type of microorganisms that causes urinary infections and to assess the antimicrobial sensitivity pattern. A hospital based short term prospective cross-sectional study was conducted at Sagar Hospital, Bengaluru from August to October 2020. Antimicrobial susceptibility in MIC test was performed for the isolated pathogens by using automated VITEK compact method and stratification was done according to ICU and NON-ICU patients with over 260 urine culture tests of the suspected in-patient for urinary tract infection. All antimicrobial susceptibility data was analyzed using WHONET software 5.6. Sixty-six urine culture tests showed culture positive, 41 from non-ICU and 23 from ICU. Gram-negative bacilli E.Coli (61% in ICU, 52% IN non-ICU) was the most prevalent bacterium, followed by Klebsiella pneumoniae ss. pneumoniae (9% in ICU, 20% IN non-ICU), and Candida albicans 9% prevalence was seen only in ICU isolates. The study shows that the rate of resistance towards ampicillin (100%) was high among gram negative isolates and penicillin (100%) among gram positive isolates. The susceptibility was favorable towards polymixinB, colistin in gram negative organisms and nitrofurantoin, vancomycin in gram positive organisms. The present study revealed that E.Coli is the predominant bacterial pathogen. It also demonstrates there is an increasing resistance to ampicillin (88.2%) and ESBL (90%) among UTI pathogens. While, polymixin B (100%) and colistin was found most effective among gram negative and nitrofurantoin was most effective among gram positive organisms.

Keywords: Antibiotic, antimicrobial resistance, urinary tract infection
Development and Evaluation of Micro Emulsion Formulations of Nebivolol for Solubility Enhancement
Authors: Kaur Gurleen , Saifi Alfisha , Kumar Kapil , Teotia Deepak
Published: September 2021

Nebivolol HCl is a newer drug of β1-adrenergic blocker category, basically used as anti-hypertensive. It is a 3rd generation, antagonist, having NO (nitric oxide) enhancing vasodilator properties. It has 12% oral bioavailability, because of its pre systemic metabolism by the means of cytochrome P450 2D6 enzymes. Its log P value is 4.03 and 5mg is its daily dose. It is highly lipophilic drug and belongs to class BCS II, with slow dissolution. Bioavailability of any drug can be improved by avoiding its first pass metabolism and promoting solubility.  Several researchers have worked on the development of ME formulations on different poor water-soluble drugs, to increase their solubility. The purpose of this study is an attempt to enhance the solubility to improve the bioavailability of nebivolol drug by developing a novel delivery system that is microemulsion (ME) .ME formulations were developed using different oil, surfactant and co-surfactants in different ratio and studied on various parameters. Different preformulation tests done on received sample of Nebivolol. FTIR study was performed in order to find out any interactions between the ingredients. Based on the solubility Capmul Pg-12 was finalized oil, Tween 80 as surfactant, propylene glycol as the cosurfactant based on solubility and emulsification efficiency. Five Nebivolol ME formulations were successfully developed by use of oil, water, SA and Co-SA different ratio. Prepared formulations were studied for different properties- transmittance (%), pH, refractive index, viscosity, drug content, and solubility. It was seen that after 4 hours of diffusion, the drug released from the formulation ME5 is faster and more than that of the other i.e., 90.2±0.06%. It was found that ME5 was more stable and Soluble than other prepared formulations. With the better solubilty the bioavailability of Nebivolol will increased and helps in faster absorption and High diffusion in systemic circulation with lower or no risk of degradation. It somehow also reduced frequent intake of drug.

Keywords: Nebivolol, micro emulsion, Ternary phase diagram, surfactant, co-surfactant.
Evaluating Aged Consumers Insight Regarding Modern Medicine and Traditional Medicine
Authors: Suranjan Bantupalli , Kumar S Bala Yaswanth , Deekshit Atluri
Published: September 2021

The term traditional medicine is used to explain the traditional medical practice that has been in existence even before the advent of modern medicine. It is widely accepted and used in the prevention and treatment of physical and mental treatment as well as a social imbalance. There seem to be limits to the development of new drugs based exclusively on modern technologies. Since the 1980s, the pharmaceutical industry has tended to use high throughput synthesis and drug development based on combinatorial chemistry in developing new drugs/medicines. However, significant efforts in this direction have not resulted in the drug's expected productivity. Some large pharmaceutical companies are facing significant challenges in developing new products. Our study was to evaluate the aged population's insight regarding traditional medicine and modern medicine. It was a prospective study with duration of three months from February 2021 to April 2021. The study was conducted in the population in and around Vijayawada. A total of 400 samples were collected. Generally, nowadays people are not aware of traditional medicines even if they are inexpensive when compared to modern drugs.  So we conducted this study to know the knowledge of aged peoples on traditional medicine and to know their perception regarding both modern medicine and traditional medicine.

Keywords: Traditional medicine, Modern medicine, Natural, Aged, Population.
Teaching Russian verbs of motion to Turkish students, considering national linguistic picture of the worlds
Authors: Khavronina Serafima A. , Emrak Kasim
Published: September 2021

The article deals with Russian prefixed verbs of motion in the reflection of the Turkish language. The topic is relevant due to the fact that in recent years the role of Russian language learning in Turkey is increasing because of the expansion of economic and cultural relations between the two countries. The aim of the study is to create a linguodidactic basis for developing methodological recommendations for teaching Russian prefixed verbs of motion to Turkish students. Different methods have been used to realize the goal. The article is based on the dissertations, textbooks and manuals on the Russian language for foreigners, scientific works comparing the Russian and Turkish languages. The study of verbs of motion in the practical course of the Russian language for Turkish students has a special place. Russian and Turkish language speakers perceive the world and their identity differently. The differences between the pictures of the world are reflected in culture and language, its vocabulary and grammatical categories. Thus, while there are universals in the verb systems of the Russian and Turkish languages, there are also significant differences in the idea of action, state, change, movement, denoted by verb units in the two languages. Russian prefixed verbs of motion do not have exact equivalents in Turkish and are translated by means of verbs with different root or translation transformations. The results of the comparative description of Russian prefixed verbs of motion and transferring their meanings in Turkish, and the identified differences served as the basis for developing methodological recommendations for teaching Russian prefixed verbs of motion to Turkish students, taking into account their native language. Basing on the research, a system of teaching prefixed verbs of motion to Turkish students, including methods of verb presentation and consolidation in oral and written speech, was developed. The prospects of this work are to create a nationally-oriented textbook on the topic Russian prefix verbs of motion.
Textometr: an online tool for automated complexity level assessment of texts for Russian language learners
Authors: Laposhina Antonina N. , Lebedeva Maria Yu.
Published: September 2021

Evaluation of text accessibility seems to be an extremely urgent and labor-consuming task in the process of preparing texts for teaching Russian as a foreign language. On the other hand, the procedure of assigning a text to one of the levels on the CEFR scale (from A1 to C2) is well-formalized and described in the professional literature, which opens opportunities for its automation. This paper presents Textometr - a new free web-based tool for estimating CEFR level and other key statistics from any given text in Russian that can be relevant for adapting it for foreign students. The automated assessment of the text level here is based on a regression model, trained on the dataset of more than 800 texts from Russian textbooks for foreigners, applying several machine learning and natural language processing methods. In addition to the CEFR level, the tool provides information relevant for adapting the text to educational tasks: lists of keywords and words for a potential vocabulary list, statistics on the text coverage by frequency lists and CEFR-graded vocabulary lists (lexical minima), a frequency list of the text, a forecast of the time needed for reading. The tool shortages at the current stage of development and suggested ways to solve them are also discussed. Finally, the results of the test on the tool quality and the vectors for its further development are reported. Textometr can provide helpful information not only to teachers and guidance teachers, but to authors of textbooks and publishers to check the compliance of the text content with the declared level and educational goals.
Leucoplasia: revisão de literatura e apresentação de caso clínico
Authors: Barbachan João Jorge Diniz , Rados Pantelis Varvaki , Sant'Ana Fllho Manoel , Domingues Manoela Gallicchio
Published: September 2021

Leucoplakia is a clinica' term that refers to an alteration on the oral mucosa with the appearance of white patchers that are firmly adhered and cannot be classified as any other diagnosable discase. They are considered premalignant lesions due to the increase in the risk of malignant transformation. In this case, around 4% to 6% of the lesions evolve to cancer. Then, it is necessary to estabilish a correct and early diagnose and also a precise treatment to reach good results. The periodical control of the patients that show this kind of alteration is extremely important. The aim of this study is to discuss the possible ethiological agents, clinical and histopathological aspects as well as, the treatment and prognoses through literature review, illustrating with a clinical case.
Modelo Correlacional de Sólidos Suspendidos Totales Presentes en Aguas Residuales Domésticas Mediante Análisis de Turbiedad
Authors: Bolivar-Cuartas Sandra M. , Castaño-Muñoz Diego L. , Gutiérrez-Flórez Omar D.
Published: September 2021

Introducción: Standard Methods Organization definió una serie de métodos analíticos que permiten medir la calidad del agua, entre los que puede citarse la norma 2540 D como el método convencional para determinar la cantidad de sólidos suspendidos totales (SST). Este método, sin embargo, toma mucho tiempo (2 horas) en desarrollarse, por lo que actualmente existen diversos esfuerzos para cuantificar los SST de forma más rápida, mediante su correlación con otros parámetros fisicoquímicos. En este sentido, los parámetros SST y turbiedad son de gran interés en esta investigación, con los cuales se busca establecer una posible correlación usando un modelo matemático simple. Objetivo: el propósito de esta investigación es establecer un modelo de correlación entre la concentración de sólidos suspendidos totales (SST) y unidades nefelométricas de turbiedad (NTU) en muestras de Caolín que permita una determinación rápida e in-situ de los niveles de SST en aguas residuales domésticas. Materiales y Métodos: el desarrollo experimental fue realizado en tres etapas: primero, se prepararon soluciones a partir de Caolín a las que se les determinó la turbiedad; segundo, se realizó una regresión lineal que contempló como variables los parámetros de concentración de SST y turbiedad por nefelometría; y tercero, se tomaron dos muestras de aguas residuales domésticas proveniente de un afluente y un acuario, a la que se le aplicaron las mismas mediciones, SST y turbiedad. Resultados: se construyó una curva de calibración donde se muestra la regresión lineal entre SST y turbiedad, posteriormente, se interpolan las NTU de las muestras de agua problema con la concentración de SST y se obtuvo como resultado 47,69mgSST/L para el afluente y 106,29mgSST/L para el agua del acuario, los cuales presentan una diferencia de 2,7 % y 1,7 % respectivamente con relación a los valores estimados con el método termogravimétrico convencional (norma 2540 D) 49mgSST/L y 104,50mgSST/L. Conclusión: es posible establecer un modelo correlacional para la determinación de la concentración de SST en muestras de aguas residuales domésticas usando el método de turbiedad.
Estrategias de Planeación para la Valorización Sostenible de Residuos Truchícolas y Camaroneros en Nariño
Authors: Portillo-Melo Danyeli Maricel , Rúales-Suárez Katherin Julieth , Burgos-Flórez Marco Antonio , López-Macías Jorge Nelson , Ríos Luis Alberto
Published: September 2021

del departamento de Nariño (Colombia) genera trabajo y empleo, seguridad alimentaria y oportunidades de exportación, sin embargo, no involucra procesos adecuados para gestionar los residuos derivados. Desde el año 2015 a 2018 se generaron 1.040 toneladas de vísceras de trucha arcoíris (Oncorhynchus mykiss) en Pasto y 1.386 toneladas de cabeza y exoesqueleto de camarón (Litopenaeus) en Tumaco. El Objetivo de este artículo es identificar desde la perspectiva de los principios de bioeconomía y planeación participativa, estrategias que promuevan la valorización de los residuos truchícolas y camaroneros. Materiales y métodos: en la primera etapa se revisó los principales instrumentos de planeación para la acuicultura y pesca y se realizó una entrevista semiestructurada a los actores productivos, institucionales y académicos relacionados, y en la segunda etapa se aplicó la Metodología de Marco Lógico (MML), todo en el año 2020. Los Resultados arrojan la pertinencia de desarrollar tres componentes estratégicos en el mediano plazo en el ámbito técnicoproductivo, ambiental y organizacional, tanto en Pasto como en Tumaco: 1) modelos productivos y tecnificados de aprovechamiento de residuos, 2) condiciones para la producción acuícola y valorización de residuos en función de los ecosistemas, y 3) desarrollo comunitario y socio empresarial auto-sostenibles. Conclusiones: existe voluntad de los actores sociales involucrados en la cadena acuícola para emprender procesos de investigación, planeación y aprovechamiento técnico y biológico de vísceras de trucha en el corregimiento del Encano (Pasto) y de camarón en el municipio de Tumaco.
Valorización de Residuos de Bagazo de Caña y Plásticos para la Generación de Compuestos Energéticos
Authors: Correa-Gallego Valeria , Villegas-Bolaños Paola Andrea
Published: September 2021

El consumo desmedido y la demanda energética a nivel mundial han generado la necesidad de incorporar los desechos plásticos y de origen agroindustrial a procesos de valorización, para obtener productos energéticos alternativos a partir de tratamientos termoquímicos como la pirólisis rápida, en la cual se generan productos sólidos, líquidos y gaseosos. Desarrollar metodologías que permitan realizar un reciclaje y/o aprovechamiento de residuos generados de diversas industrias, en específico, la polimérica y la agroindustrial, es de suma importancia, dada la contaminación crónica y el impacto ambiental en ecosistemas naturales, cuerpos hídricos y fauna. El objetivo de este artículo es analizar los impactos ambientales de la alta generación de residuos plásticos y agroindustriales, así como determinar la relación entre las condiciones de operación y el rendimiento y selectividad de los productos generados con las características fisicoquímicas de los catalizadores empleados en la pirólisis rápida en pro de la valorización de dichos residuos. Lo anterior se realizó mediante una revisión de la literatura en bases de datos reconocidas para obtener artículos de investigación actualizados y con validez científica. Se encontró que la pirólisis catalizada presenta una mejora respecto al rendimiento y distribución de los productos según la fase activa seleccionada en la que la naturaleza de los metales usados conduce a diversas rutas químicas y por ende, a productos ricos en hidrocarburos.
PATTERN OF GLYCEMIC STATUS AFTER STEROID ADMINISTRATION FOR FETAL LUNG MATURITY IN NORMOGLYCEMIC PREGNANT WOMEN ; A CLINICAL ANALYSIS
Authors: IESHA BRUCE S A , Rachel Alexander A , lalithambica K , T Jacob Jaimie
Published: September 2021

Objectives To study the patterns of glycemic status in response to
steroid administered to women with risk of preterm delivery between 24
weeks and 36 weeks 6 days of gestation in normoglycemic subjects and to
evaluate if maternal characteristics predicted the development of
hyperglycemia and if Insulin was necessary in the glycemic management
Design : longitudinal study Participants : 76 antenatal women,
normoglycemic status between 24 weeks and 36 week 6 days of gestation
Methods : Antenatal women who screened negative for Gestational Diabetes
Mellitus by 75 gm GTT who received Injection Betamethasone for risk of
preterm delivery . Fasting and Postprandial blood sugar levels were
recorded from day 1 to 7 after steroid administration. Results Forty
seven out of seventy six patients had hyperglycemia of varying severity.
Among the risk factors associated with hyperglycemia,
age>25 years, family history ofdiabetes and hypertension
and BMI >25 have statistically significant association with
hyperglycemia. Insulin was started in a total of 40 patients of 47
hyperglycemic patients (85.1%). Mean Insulin dosage required for day 1
was9.66 units. Among the 40 patients started on Insulin 15 (37.5 %) had
to be continued on Insulin on Day 7 after steroid administration.
Conclusion Significant hyperglycemia can occur in normoglycemic women
also leading to serious maternal- fetal consequences . Testing of all
antenatal patients especially in age group more than 25years, BMI over
25, hypertensive patients, family history of diabetes who are at risk
for development of hyperglycemia ie recommended and start insulin
accordingly thus preventing complications.
The Relationship between Perceived Job Satisfaction, Commitment and Loyalty in Banking Sector
Authors: Naz Yafra , Lohano Sadhna , Khatri Abeer
Published: September 2021

In the current era of highly volatile corporate environment, organizations are facing challenges in the form of optimization of human resources in the banking sector of Pakistan. Human resources are measured as a source of ecological competitive advantage. The success of an organization depends upon several factors but the most decisive factor that effect the organizational performance and its employees. Job satisfaction is one of the most broadly discussed and devotedly studied paradigms in related disciplines such as industrial-organizational psychology, organizational behavior. The job satisfaction is the favorable or un-favorable attitude with which the employee views his and her work. Job satisfaction, thus, is the result of various attitudes possessed by an employee. The current study is in endeavor to observe and explore the impact of human resources practices on job satisfaction, Commitment & loyalty of private and public sector banking employees. In the study the scientific management model, identify that Human resource management practices like training performance appraisal teamwork and compensationhas significant impact on job satisfaction.
Gêneros textuais, multiletramento e produção de jornal digital
Authors: Parreão Madalena Regina Garcia , Mello Ângela Rita Christofolo de
Published: September 2021

Este artigo apresenta resultados de uma pesquisa ação, de abordagem qualitativa, realizada com o objetivo de incentivar o trabalho com diferentes gêneros textuais da esfera jornalística em práticas educacionais de incentivo à leitura e à produção de textos a partir da criticidade dos estudantes matriculados no 9º ano do ensino fundamental, acerca da realidade social. O resultado deste trabalho permite afirmar que os conteúdos quando trabalhados de forma contextualizada e articulada aos fatos atuais, darão vida e sentido aos temas estudados nas aulas de Língua Portuguesa. Esses aspectos são recomendados porque poderão mudar os resultados obtidos na aprendizagem.
Ouvidoria-Geral do Estado de Pernambuco: análise dos relatórios de gestão da Secretaria Estadual de Educação (2015-2019)
Authors: Oliveira Dayzi Silva , Arruda Ana Lúcia Borba de
Published: September 2021

O presente trabalho tem como objetivo analisar os relatórios de gestão da Ouvidoria-Geral do Estado de Pernambuco (OGE) que contemplam dados da Secretaria de Educação (SEE-PE) entre o período de 2015-2019 tendo como foco a natureza das manifestações e como estas são organizadas e apresentadas. Teve como base metodológica pesquisa dos documentos e leituras bibliográficas (BORDENAVE, 1994; DEMO, 1993; GOHN, 2019; LAVALLE, 2015). Os resultados mostraram as possibilidades das ouvidorias públicas como um espaço de participação, todavia, demandam ações ampliadas, entre outras, de transparência ativa e organização das informações disponibilizadas.