bluuebunny/crossref_metadata_2025 huggingface dataset:
d-Allulose Inhibits Ghrelin-Responsive, Glucose-Sensitive and Neuropeptide Y Neurons in the Arcuate Nucleus and Central Injection Suppresses Appetite-Associated Food Intake in Mice
Authors: Rakhat Yermek , Kaneko Kentaro , Wang Lei , Han Wanxin , Seino Yutaka , Yabe Daisuke , Yada Toshihiko
Published: August 2022

d-allulose, a rare sugar, has sweetness with few calories. d-allulose regulates feeding and glycemia, and ameliorates hyperphagia, obesity and diabetes. All these functions involve the central nervous system. However, central mechanisms underlying these effects of d-allulose remain unknown. We recently reported that d-allulose activates the anorexigenic neurons in the hypothalamic arcuate nucleus (ARC), the neurons that respond to glucagon-like peptide-1 and that express proopiomelanocortin. However, its action on the orexigenic neurons remains unknown. This study investigated the effects of d-allulose on the ARC neurons implicated in hunger, by measuring cytosolic Ca2+ concentration ([Ca2+]i) in single neurons. d-allulose depressed the increases in [Ca2+]i induced by ghrelin and by low glucose in ARC neurons and inhibited spontaneous oscillatory [Ca2+]i increases in neuropeptide Y (NPY) neurons. d-allulose inhibited 10 of 35 (28%) ghrelin-responsive, 18 of 60 (30%) glucose-sensitive and 3 of 8 (37.5%) NPY neurons in ARC. Intracerebroventricular injection of d-allulose inhibited food intake at 20:00 and 22:00, the early dark phase when hunger is promoted. These results indicate that d-allulose suppresses hunger-associated feeding and inhibits hunger-promoting neurons in ARC. These central actions of d-allulose represent the potential of d-allulose to inhibit the hyperphagia with excessive appetite, thereby counteracting obesity and diabetes.
Associations between the Nutrient Profiling System Underlying the Nutri-Score Nutrition Label and Biomarkers of Chronic Low-Grade Inflammation: A Cross-Sectional Analysis of a Middle- to Older-Aged Population
Authors: Millar Seán R. , Navarro Pilar , Harrington Janas M. , Perry Ivan J. , Phillips Catherine M.
Published: August 2022

Low-grade systemic inflammation is associated with a range of conditions. Diet may modulate inflammation and public health strategies are needed to guide consumers’ dietary choices and help prevent diet-related disease. The Food Standards Agency nutrient profiling system (FSAm-NPS) constitutes the basis of the five-colour front-of-pack Nutri-Score labelling system. No study to date has examined FSAm-NPS dietary index associations with biomarkers of inflammation. Therefore, our objective was to test relationships between the FSAm-NPS and a range of inflammatory biomarkers in a cross-sectional sample of 2006 men and women aged 46–73 years. Individual participant FSAm-NPS scores were derived from food frequency questionnaires. Pro-inflammatory cytokine, adipocytokine, acute-phase response protein, coagulation factor and white blood cell count concentrations were determined. Correlation and linear regression analyses were used to examine FSAm-NPS relationships with biomarker levels. In crude and adjusted analyses, higher FSAm-NPS scores, reflecting poorer nutritional quality, were consistently and positively associated with biomarkers. In fully adjusted models, significant associations with concentrations of complement component 3, c-reactive protein, interleukin 6, tumour necrosis factor alpha, resistin, white blood cell count, neutrophils, eosinophils and the neutrophil-to-lymphocyte ratio persisted. These results suggest that dietary quality, determined by Nutri-Score rating, is associated with inflammatory biomarkers related to health.
Eating Habits in Patients with Familial Hypercholesterolemia from North-Eastern Romania
Authors: Maștaleru Alexandra , Cojocariu Alexandra Sabina , Oancea Andra , Leon-Constantin Maria-Magdalena , Roca Mihai , Zota Ioana Mădălina , Abdulan Irina Mihaela , Rusu Cristina , Trandafir Laura Mihaela , Costache Alexandru Dan , Cojocaru Elena , Roca Iulia Cristina , Mitu Florin
Published: August 2022

(1) Background: Familial hypercholesterolemia (FH) is a genetic autosomal dominant disorder characterized by elevated levels of low-density lipoprotein cholesterol (LDL) that develops deposits of lipids in the arterial wall. Since it is underdiagnosed and undertreated, the disease has a high risk of premature cardiovascular disease and death. Patients are not always aware of the changes they should make in their diet. Thus, our study aimed to evaluate through a food frequency questionnaire their eating habits. (2) Methods: We included 70 patients with FH and 20 subjects in a control group that were evaluated through a physical examination and blood tests. They also completed a food frequency questionnaire. (3) Results: Throughout our study, we observed several aspects: regardless of age, patients with FH had higher carbohydrate intakes compared to the control group; from the same group, a positive correlation was observed between salami intake and the levels of glucose and glycated hemoglobin. Moreover, the sour cream preference was associated with higher liver function tests. In the control group, we observed a higher intake of pasta and fast food and fewer fruit portions. (4) Conclusions: As far as we know, this is the first study from Romania that evaluated the eating habits of patients diagnosed with FH. Our study reveals that, although patients with FH avoid junk food, they still have a high intake of carbohydrates when compared to the control group. Further research is needed in order to get a comprehensive nutritional evaluation of these patients.
Sex-Dependent Effects of the Intake of NOVA Classified Ultra-Processed Foods on Syndrome Metabolic Components in Brazilian Adults
Authors: Magalhães Elma Izze da Silva , de Oliveira Bianca Rodrigues , Rudakoff Lívia Carolina Sobrinho , de Carvalho Vitória Abreu , Viola Poliana Cristina de Almeida Fonseca , Arruda Soraia Pinheiro Machado , de Carvalho Carolina Abreu , Coelho Carla Cristine Nascimento da Silva , Bragança Maylla Luanna Barbosa Martins , Bettiol Heloisa , Barbieri Marco Antônio , Cardoso Viviane Cunha , dos Santos Alcione Miranda , Levy Renata Bertazzi , da Silva Antônio Augusto Moura
Published: August 2022

Longitudinal studies evaluating the relationship between UPF consumption and the incidence of Metabolic Syndrome (MetS) and its components are still scarce. This study aimed to evaluate the effect of UPF consumption on the incidence of MetS and its components in adults. A prospective study was conducted with 896 participants from the 1978/79 Ribeirão Preto cohort, São Paulo, Brazil. UPF consumption was evaluated in %kcal and %g at ages 23–25 years. Incidence of MetS and its components were estimated at ages 37–39 years, according to the Joint Interim Statement criteria. Poisson regression was used to assess associations, and interactions with sex were investigated. UPF consumption had no association with MetS (%kcal Adjusted PR: 1.00; 95% CI: 0.99–1.01; %g Adjusted PR: 1.00; 95% CI: 0.99–1.01). However, women with higher UPF consumption, in %kcal and %g, had a higher risk of abdominal obesity (%kcal: p = 0.030; %g: p = 0.003); and women with higher UPF consumption, in %g, had a higher risk of low HDL-cholesterol (p = 0.041). For the other components of MetS, no significant associations were observed in either sex. These findings suggest evidence of no association between UPF consumption and MetS; however, consumption of UPF was associated with increased WC and low HDL-c, but only in women.
The Efficacy of Camelina sativa Defatted Seed Meal against Colitis-Induced Persistent Visceral Hypersensitivity: The Relevance of PPAR α Receptor Activation in Pain Relief
Authors: Lucarini Elena , Micheli Laura , Pagnotta Eleonora , Toti Alessandra , Ferrara Valentina , Ciampi Clara , Margiotta Francesco , Martelli Alma , Testai Lara , Calderone Vincenzo , Matteo Roberto , Suriano Serafino , Troccoli Antonio , Pecchioni Nicola , Manera Clementina , Mannelli Lorenzo Di Cesare , Ghelardini Carla
Published: August 2022

Brassicaceae are natural sources of bioactive compounds able to promote gut health. Belonging to this plant family, Camelina sativa is an ancient oil crop rich in glucosinolates, polyunsaturated fatty acids, and antioxidants that is attracting renewed attention for its nutraceutical potential. This work aimed at investigating the therapeutic effects of a defatted seed meal (DSM) of Camelina sativa on the colon damage and the persistent visceral hypersensitivity associated with colitis in rats. Inflammation was induced by the intrarectal injection of 2,4-dinitrobenzenesulfonic acid (DNBS). The acute administration of Camelina sativa DSM (0.1–1 g kg−1) showed a dose-dependent pain-relieving effect in DNBS-treated rats. The efficacy of the meal was slightly enhanced after bioactivation with myrosinase, which increased isothiocyanate availability, and drastically decreased by pre-treating the animals with the selective peroxisome proliferator-activated receptor alpha (PPAR α) receptor antagonist GW6471. Repeated treatments with Camelina sativa DSM (1 g kg−1) meal counteracted the development, as well as the persistence, of visceral hyperalgesia in DNBS-treated animals by reducing the intestinal inflammatory damage and preventing enteric neuron damage. In conclusion, Camelina sativa meal might be employed as a nutraceutical tool to manage persistent abdominal pain in patients and to promote gut healing.
Blenderised Tube Feeds vs. Commercial Formula: Which Is Better for Gastrostomy-Fed Children?
Authors: Chandrasekar Neha , Dehlsen Kate , Leach Steven T. , Krishnan Usha
Published: August 2022

Blenderised tube feeds (BTF) have become a popular alternative to commercial formula (CF) for enterally fed children. This study sought to compare gastrointestinal (GI) symptoms, GI inflammation, and stool microbiome composition between children receiving BTF or CF. This prospective cohort study involved 41 gastrostomy-fed children, aged 2–18 years, receiving either BTF (n = 21) or CF (n = 20). The Paediatric Quality of Life Inventory Gastrointestinal Symptoms Scale (GI-PedsQL) was used to compare GI symptoms between the groups. Anthropometric data, nutritional intake, nutritional blood markers, faecal calprotectin levels, stool microbiota, and parental satisfaction with feeding regimen were also assessed. Caregivers of children on BTF reported greater GI-PedsQL scores indicating significantly fewer GI symptoms (74.7 vs. 50.125, p = 0.004). Faecal calprotectin levels were significantly lower for children receiving BTF compared to children on CF (33.3 mg/kg vs. 72.3 mg/kg, p = 0.043) and the BTF group had healthier, more diverse gut microbiota. Subgroup analysis found that 25% of caloric intake from BTF was sufficient to improve GI symptoms. The CF group had better body mass index (BMI) z-scores (−0.7 vs. 0.5, p = 0.040). Although growth was poorer in children receiving only BTF in comparison to the CF group, this was not seen in children receiving partial BTF. A combination of BTF and CF use may minimise symptoms of tube feeding whilst supporting growth.
Underestimating College Student Food Insecurity: Marginally Food Secure Students May Not Be Food Secure
Authors: Brescia Stephanie A. , Cuite Cara L.
Published: August 2022

The purpose of this study was to understand the demographic, student, financial, and academic differences between marginally food secure college students and students with high, low, or very low food security (FS). Unlike highly food secure students, marginally food secure students worry about the quantity and quality of their food, yet they are classified in the same category as highly food secure individuals as per the United States Department of Agriculture (USDA) reporting standards. To investigate marginal FS among college students, a cross-sectional online survey was administered at a large, public, research university in the Northeastern United States. A largely representative sample of 6823 undergraduate students completed the survey with a 19.7% response rate. Self-reported level of FS was measured using the validated USDA 10-item FS survey module. Independent variables, such as demographic and student characteristics and cumulative grade point average (GPA), were gathered from institutional databases, and self-reported mechanisms of financing education were measured using a novel scale. Results from the multinomial logistic regression revealed statistically significant differences in GPA between students with marginal and high FS (p < 0.001), but not between students with marginal and low FS (p = 0.31). This work has implications beyond college students and suggests that marginally food secure populations should not be labeled as food secure.
Dietary Intake of Vegan and Non-Vegan Endurance Runners—Results from the NURMI Study (Step 2)
Authors: Wirnitzer Katharina , Wagner Karl-Heinz , Motevalli Mohamad , Tanous Derrick , Wirnitzer Gerold , Leitzmann Claus , Rosemann Thomas , Knechtle Beat
Published: August 2022

Nowadays, the growing popularity of distance running has been accompanied by the increasing prevalence of vegan and vegetarian diets, especially among endurance athletes. The present study aimed to examine the association between diet type and dietary intake of distance runners competing at distances longer than 10 km. From a total of 317 participants, 211 endurance runners (57% females) were considered the final sample after applying the exclusion criteria. Runners were assigned to three groups based on the self-reported diet types: 95 omnivores, 40 vegetarians, and 76 vegans. Data collection was conducted using an online survey with questions about sociodemographic information, dietary intake, and dietary-associated motives. A comprehensive food frequency questionnaire with 53 food groups (categorized in 14 basic—plus three umbrella—food clusters) was used to assess dietary intake. Vegan runners had a higher intake of “beans and seeds”, “fruit and vegetables”, and “dairy alternatives”, as well as lower intakes of “oils” than other two groups. Vegetarian runners had a lower intake of “dairy products” and “eggs” than omnivores. A greater intake of “alcohol” and a lower intake of “meat alternatives” was observed in omnivorous runners compared to vegans and vegetarians. Despite the existence of a tendency toward the consumption of health-related food clusters by vegan runners, further investigations are needed to verify the predominance of vegans in health-oriented dietary patterns.
Akkermansia muciniphila Colonization Alleviating High Fructose and Restraint Stress-Induced Jejunal Mucosal Barrier Disruption
Authors: Yu Jiayu , Liu Tianlong , Gao Zihao , Liu Runbang , Wang Zixu , Chen Yaoxing , Cao Jing , Dong Yulan
Published: August 2022

Akkermansia muciniphila (A. muciniphila) is a mucin-degrading bacterium that resides in the mucus layer, but its potential in intestinal inflammatory diseases has sparked controversy. It is well known that both the consumption of fructose-containing beverages and psychological stress increase the risk of intestinal disease. Our results revealed that a high-fructose diet aggravated the damage to the jejunal mucosal barrier caused by restraint stress, reduced tight junction protein expression and the intestinal digestion and absorption capacity, disrupted the ability of Paneth cells to secrete antimicrobial peptides, and promoted the expression of inflammatory cytokines. A. muciniphila colonization enhanced the defense function of the mucosal barrier by enhancing the function of the NLRP6, promoting autophagy, maintaining the normal secretion of antimicrobial peptides in Paneth cells, promoting the expression of tight junction proteins, negatively regulating the NF-kB signaling pathway and inhibiting the expression of inflammatory cytokines. Our work indicates that A. muciniphila ameliorates the disruption of the intestinal mucosal barrier under high fructose and restraint stress. These results provided a rationale for the development of probiotic colonization for the prevention or treatment of intestinal diseases.
Mapping of Outdoor Food and Beverage Advertising around Spanish Schools
Authors: Martin-Payo Ruben , González-Moradas María del Rosario , Iturrate-Bobes Juan , Fernández-Sutil Alejandro , Cofiño Rafael , Fernandez-Alvarez María del Mar
Published: August 2022

Overweight and obesity rates have increased worldwide in the last decades. The marketing strategies of food considered to be unhealthy significantly exacerbate the childhood obesity dilemma. Studies typically analyze the content of advertisement in television, movies, or social media, but there is a gap in the assessment of the real-life promotion of food and beverages around the schools. The primary aim of the study was to assess the products advertised around public and concerted schools in three cities in the north of Spain, and to categorize them as healthy (core) or unhealthy (discretionary). The secondary aim was to describe the types of food and beverages in advertisements, as well as to determine the density of core and discretionary product advertisements. A cross-sectional descriptive study was carried out between September and December 2021. The units of analysis were outdoor food and beverage advertisements that were located around public and concerted schools of three cities in the north of Spain. We found 104 schools that met the criteria. We identified 6469 products advertised, 35.1% core and 61.2% discretionary, observing significant differences (p < 0.001) among the cities. Fruit (core) and alcohol (discretionary) were the most heavily advertised products. In conclusion, children attending schools located in the assessed cities are currently exposed to a significant amount of discretionary product advertisement, a situation that should be regulated.
A Narrative Review of Auditory Categorisation and Its Potential Role in Tinnitus Perception
Authors: Vajsakovic Dunja , Maslin Michael R. D. , Searchfield Grant D.
Published: August 2022

Auditory categorisation is a phenomenon reflecting the non-linear nature of human perceptual spaces which govern sound perception. Categorisation training paradigms may reduce sensitivity toward training stimuli, decreasing the representation of these stimuli in auditory perceptual maps. Reduced cortical representation may have clinical implications for conditions that arise from disturbances in cortical activation, such as tinnitus. This review explores the categorisation of sound, with a particular focus on tinnitus. The potential of categorisation training as a sound-based tinnitus therapy is discussed. A narrative review methodological framework was followed. Four databases (PubMed, Google Scholar, Scopus, and ScienceDirect) were extensively searched for the following key words: categorisation, categorical perception, perceptual magnet effect, generalisation, and categorisation OR categorical perception OR perceptual magnet effect OR generalisation AND sound. Given the exploratory nature of the review and the fact that early works on categorisation are crucial to the understanding and development of auditory categorisation, all study types were selected for the period 1950–2022. Reference lists of articles were reviewed to identify any further relevant studies. The results of the review were catalogued and organised into themes. In total, 112 articles were reviewed in full, from which 59 were found to contain relevant information and were included in the review. Key themes identified included categorical perception of speech stimuli, warping of the auditory perceptual space, categorisation versus discrimination, the presence of categorisation across several modalities, and categorisation as an innate versus learned feature. Although a substantial amount of work focused on evaluating the effects of categorisation training on sound perception, only two studies investigated the effects of categorisation training on tinnitus. Implementation of a categorisation-based perceptual training paradigm could serve as a promising means of tinnitus management by reversing the changes in cortical plasticity that are seen in tinnitus, in turn altering the representation of sound within the auditory cortex itself. In the instance that the categorisation training is successful, this would likely mean a decrease in the level of activity within the auditory cortex (and other associated cortical areas found to be hyperactive in tinnitus) as well as a reduction in tinnitus salience.
Role of Calcimimetics in Treating Bone and Mineral Disorders Related to Chronic Kidney Disease
Authors: Hou Yi-Chou , Zheng Cai-Mei , Chiu Hui-Wen , Liu Wen-Chih , Lu Kuo-Cheng , Lu Chien-Lin
Published: August 2022

Renal osteodystrophy is common in patients with chronic kidney disease and end-stage renal disease and leads to the risks of fracture and extraosseous vascular calcification. Secondary hyperparathyroidism (SHPT) is characterized by a compensatory increase in parathyroid hormone (PTH) secretion in response to decreased renal phosphate excretion, resulting in potentiating bone resorption and decreased bone quantity and quality. Calcium-sensing receptors (CaSRs) are group C G-proteins and negatively regulate the parathyroid glands through (1) increasing CaSR insertion within the plasma membrane, (2) increasing 1,25-dihydroxy vitamin D3 within the kidney and parathyroid glands, (3) inhibiting fibroblast growth factor 23 (FGF23) in osteocytes, and (4) attenuating intestinal calcium absorption through Transient Receptor Potential Vanilloid subfamily member 6 (TRPV6). Calcimimetics (CaMs) decrease PTH concentrations without elevating the serum calcium levels or extraosseous calcification through direct interaction with cell membrane CaSRs. CaMs reduce osteoclast activity by reducing stress-induced oxidative autophagy and improving Wnt-10b release, which promotes the growth of osteoblasts and subsequent mineralization. CaMs also directly promote osteoblast proliferation and survival. Consequently, bone quality may improve due to decreased bone resorption and improved bone formation. CaMs modulate cardiovascular fibrosis, calcification, and renal fibrosis through different mechanisms. Therefore, CaMs assist in treating SHPT. This narrative review focuses on the role of CaMs in renal osteodystrophy, including their mechanisms and clinical efficacy.
Development and Comparison of Various Coated Hard Capsules Suitable for Enteric Administration to Small Patient Cohorts
Authors: Fülöpová Nicole , Pavloková Sylvie , DeBono Ivan , Vetchý David , Franc Aleš
Published: August 2022

Pharmaceutical technology offers several options for protecting substances from acidic environments, such as encapsulation in enteric capsules or dosage form with enteric coating. However, commercial enteric capsules do not always meet limits for pharmacopeial delayed release, and the coating process is generally challenging. Preparing small enteric batches suitable for clinical use is, therefore, an unsolved problem. This experiment offers a simple coating process of DRcapsTM capsules based on hypromellose (HPMC) and gellan gum to achieve small intestine administration. In addition, DRcapsTM capsules were compared to hard gelatin capsules to evaluate the suitability of the coating method. Both capsules were immersed in dispersions of Eudragit® S 100, Acryl-EZE®, and Cellacefate at concentrations of 10.0, 15.0, and 20.0% and dried. Coated capsules were evaluated by electron microscopy, disintegration, and dissolution test with a two-step pH change (from 1.2 to 6.8, then to 7.5) to simulate passage through the digestive tract. DRcapsTM capsules coated with Eudragit® S and Cellacefate achieved acid resistance. While samples coated with Eudragit® S released their contents within 360 min at pH 6.8 (small intestine), regardless of polymer concentration, capsules with 15.0 and 20.0% coatings of Cellacefate released content at pH 7.5 (colon) within 435 and 495 min, respectively.
When Natural Compounds Meet Nanotechnology: Nature-Inspired Nanomedicines for Cancer Immunotherapy
Authors: Yu Linna , Jin Yi , Song Mingjie , Zhao Yu , Zhang Huaqing
Published: August 2022

Recent significant strides of natural compounds in immunomodulation have highlighted their great potential against cancer. Despite many attempts being made for cancer immunotherapy, the biomedical application of natural compounds encounters a bottleneck because of their unclear mechanisms, low solubility and bioavailability, and limited efficacy. Herein, we summarize the immune regulatory mechanisms of different natural compounds at each step of the cancer-immunity cycle and highlight their anti-tumor potential and current limitations. We then propose and present various drug delivery strategies based on nanotechnology, including traditional nanoparticles (NPs)-based delivery strategies (lipid-based NPs, micelles, and polysaccharide/peptide/protein-based NPs) and novel delivery strategies (cell-derived NPs and carrier-free NPs), thus providing solutions to break through existing bottlenecks. Furthermore, representative applications of nature-inspired nanomedicines are also emphasized in detail with the advantages and disadvantages discussed. Finally, the challenges and prospects of natural compounds for cancer immunotherapy are provided, hopefully, to facilitate their far-reaching development toward clinical translation.
Therapeutic Drug Monitoring of Sputum Voriconazole in Pulmonary Aspergillosis
Authors: Sarfati Sacha , Wils Julien , Lambert Timothée , Mory Céline , Imbert Laurent , Gargala Gilles , Morisse-Pradier Hélène , Lamoureux Fabien
Published: August 2022

Voriconazole is one of the most used antifungal azoles against pulmonary aspergillosis. Therapeutic drug monitoring (TDM) of the voriconazole concentration in plasma is recommended in clinical practice guidelines to prevent treatment failure and toxicity. The aim of this study was to evaluate the feasibility and utility of TDM of the voriconazole concentration in the sputum of patients treated for pulmonary aspergillosis. Fifty sputum and 31 plasma samples were analysed with high-performance tandem mass spectrometry (HPLC-MS/MS) in 24 patients included in the study. The voriconazole concentration was simultaneously assessed in the plasma and sputum in 22 samples. The correlation between the sputum and plasma levels was estimated with a univariate linear regression model, and the observed R2 was 0.86. We determined the following equation, Csputum = 0.45 (Cplasma) + 0.21, which could predict the voriconazole concentration in plasma from sputum. TDM of the voriconazole concentration in sputum is an easy, non-invasive and accurate method with which to evaluate voriconazole exposure in patients with pulmonary aspergillosis.
Inhibition of Candida glabrata Biofilm by Combined Effect of Dendritic Compounds and Amphotericin
Authors: Gómez-Casanova Natalia , Torres-Cano Alba , Elias-Rodriguez Alba Xiaohe , Lozano Tania , Ortega Paula , Gómez Rafael , Pérez-Serrano Jorge , Copa-Patiño José Luis , Heredero-Bermejo Irene
Published: August 2022

In the last decade, Candida glabrata has become an important emerging opportunistic pathogen not only because of the increase in nosocomial infections frequency but also because of its ability to form biofilms and its innate resistance to commercial antifungals. These characteristics make this pathogen a major problem in hospital settings, including problems regarding equipment, and in immunosuppressed patients, who are at high risk for candidemia. Therefore, there is an urgent need for the development of and search for new antifungal drugs. In this study, the efficacy of two dendritic wedges with 4-phenyl butyric acid (PBA) at the focal point and cationic charges on the surface ArCO2G2(SNMe3I)4 (1) and ArCO2G3(SNMe3I)8 (2) was studied against C. glabrata strain to inhibit the formation of biofilms and eliminate established biofilm. For this, MBIC (minimum biofilm inhibitory concentration), MBDC (minimum biofilm damaging concentrations), as well as MFCB (minimum fungicidal concentration in biofilm) and MBEC (minimum biofilm eradicating concentration) were determined. In addition, different combinations of dendrons and amphotericin B were tested to study possible synergistic effects. On the other hand, cytotoxicity studies were performed. C. glabrata cells and biofilm structure were visualized by confocal microscopy. ArCO2G2(SNMe3I)4 (1) and ArCO2G3(SNMe3I)8 (2) dendrons showed both an MBIC of 8 mg/L and a MBDC of 32 mg/L and 64 mg/L, respectively. These dendrons managed to eradicate the entirety of an established biofilm. In combination with the antifungal amphotericin, it was possible to prevent the generation of biofilms and eradicate established biofilms at lower concentrations than those required individually for each compound at these conditions.
Progress in the Photoreforming of Carboxylic Acids for Hydrogen Production
Authors: Samage Anita , Gupta Pooja , Halakarni Mahaveer A. , Nataraj Sanna Kotrappanavar , Sinhamahapatra Apurba
Published: August 2022

Photoreforming is a process that connects the redox capability of photocatalysts upon light illumination to simultaneously drive the reduction of protons into hydrogen and the oxidation of organic substrates. Over the past few decades, researchers have devoted substantial efforts to enhancing the photocatalytic activity of the catalyst in hydrogen production. Currently, the realization of the potential of photocatalysts for simultaneous hydrogen production with value-added organics has motivated the research field to use the photo-oxidation path. As a distinct benefit, the less energetically demanding organic reforming is highly favorable compared to the slow kinetics of oxygen evolution, negating the need for expensive and/or harmful hole scavengers. Photocatalyst modifications, such as secondary component deposition, doping, defect, phase and morphology engineering, have been the main strategies adopted to tune the photo-oxidation pathways and oxidation products. The effect of the reaction parameters, including temperature, pH, reactant concentration and promising reactor strategies, can further enhance selectivity toward desired outcomes. This review provides a critical overview of photocatalysts in hydrogen production, including chemical reactions occurring with semiconductors and co-catalysts. The use of various oxygenates as sacrificial agents for hydrogen production is outlined in view of the transition of fossil fuels to clean energy. This review mainly focuses on recent development in the photoreforming of carboxylic acids, produced from the primary source, lignocellulose, through pyrolysis. The photo-oxidation of different carboxylic acids, e.g., formic acid, acetic acid and lactic acid, over different photocatalysts for hydrogen production is reviewed.
Classification of Textile Samples Using Data Fusion Combining Near- and Mid-Infrared Spectral Information
Authors: Riba Jordi-Roger , Cantero Rosa , Puig Rita
Published: August 2022

There is an urgent need to reuse and recycle textile fibers, since today, low recycling rates are achieved. Accurate classification methods for post-consumer textile waste are needed in the short term for a higher circularity in the textile and fashion industries. This paper compares different spectroscopic data from textile samples in order to correctly classify the textile samples. The accurate classification of textile waste results in higher recycling rates and a better quality of the recycled materials. The data fusion of near- and mid-infrared spectra is compared with single-spectrum information. The classification results show that data fusion is a better option, providing more accurate classification results, especially for difficult classification problems where the classes are wide and close to one another. The experimental results presented in this paper prove that the data fusion of near- and mid-infrared spectra is a good option for accurate textile-waste classification, since this approach allows the classification results to be significantly improved.
In Situ Fluorescent Illumination of Microplastics in Water Utilizing a Combination of Dye/Surfactant and Quenching Techniques
Authors: Park Doo Hong , Oh Se Bin , Hong Sung Chul
Published: August 2022

Although plastics have benefited our lives in terms of cost and convenience, the disposal of end-of-life plastics poses environmental problems, such as microplastics (MPs). Although the separation (e.g., filtration) and staining of MPs with fluorescent dye/solvent are generally accepted steps to observe MPs in an environmental matrix, in this study, an in situ selective fluorescent illumination of the MPs in water was attempted with the aid of surfactant. Nonpolar fluorescent dye in combination with surfactant affords nanometer-sized dye particles in water, which adsorb on MPs and penetrate the polymer matrix for effective staining and stable fluorescent behaviors. The effects of different staining parameters, including different dyes, surfactants, staining temperatures, staining times, dye/surfactant ratios, dye/MP ratios, and MP concentrations in aqueous solutions were investigated to better understand staining conditions. More interestingly, non-adsorbed free dye molecules in the staining solution were almost completely fluorescence-quenched by introducing the quenching agent, aniline, while the fluorescence intensity of the stained MP was maintained. By staining MPs with a dye/surfactant combination and subsequently quenching with aniline, in situ selective fluorescent illumination of the MPs in water was successfully achieved, which may eliminate the tedious separation/filtration procedure of MPs to accomplish the quick detection or monitoring of MPs.
An Effective Shrinkage Control Method for Tooth Profile Accuracy Improvement of Micro-Injection-Molded Small-Module Plastic Gears
Authors: Wu Wangqing , He Xiansong , Li Binbin , Shan Zhiying
Published: August 2022

An effective method to control the non-linear shrinkage of micro-injection molded small-module plastic gears by combining multi-objective optimization with Moldflow simulation is proposed. The accuracy of the simulation model was verified in a micro-injection molding experiment using reference process parameters. The maximum shrinkage (Y1), volume shrinkage (Y2), addendum diameter shrinkage (Y3), and root circle diameter shrinkage (Y4) were utilized as optimization objectives to characterize the non-linear shrinkage of the studied gear. An analysis of the relationship between key process parameters and the optimization objectives was undertaken using a second-order response surface model (RSM-Quadratic). Finally, multi-objective optimization was carried out using the non-dominated sorting genetic algorithm-II (NSGA-II). The error rates for the key shrinkage dimensions were all below 2%. The simulation results showed that the gear shrinkage variables, Y1, Y2, Y3, and Y4, were reduced by 5.60%, 8.23%, 11.71%, and 11.39%, respectively. Moreover, the tooth profile inclination deviation (fHαT), the profile deviation (ffαT), and the total tooth profile deviation (FαT) were reduced by 47.57%, 23.43%, and 49.96%, respectively. Consequently, the proposed method has considerable potential for application in the high-precision and high-efficiency manufacture of small-module plastic gears.
Potential Impacts of Prunus domestica Based Natural Gum on Physicochemical Properties of Polyaniline for Corrosion Inhibition of Mild and Stainless Steel
Authors: Kamran Muhammad , Shah Anwar ul Haq Ali , Rahman Gul , Bilal Salma
Published: August 2022

The lack of an eco-friendly approach towards application of polyaniline as a coating material has been one of the most challenging tasks. Herein, the synthesis of green Prunus domestica gum grafted polyaniline (PDG-g-PANI) composite is reported by a cost-effective emulsion polymerization for application as an efficient anti-corrosion material for mild steel (MS) and stainless steel (SS) in a strong corroding environment. The composite formation was confirmed by Ultraviolet Visible (UV-Visible) and Fourier Transformed Infrared (FTIR) spectroscopies. X-ray diffraction data revealed the amorphous nature of the PDG-g-PANI. Scanning Electron Microscopic (SEM) images showed a bi-layered structure having a parent porous layer of PANI coated with afibrous layer of PDG. The solubility test confirmed the dissolution of PDG-g-PANI in common organic solvents such as acetone, ethanol, propanol, butanol, chloroform, N-Methyl-2-pyrrolidone, dimethyl sulfoxide, and the mixture of propanol and chloroform. The polarization curve, open circuit potential, electrochemical impendence spectroscopy (EIS), and gravimetric analysis were applied to investigate the corrosion protection behavior of the composite on MS and SS in 3.5% NaCl and 1 M H2SO4 solution. The PDG-g-PANI-coated MS exhibited 96% corrosion inhibition efficiency as compared to 86% and 43% for pristine PANI and PDG in 3.5% NaCl solution while PDG-g-PANI-coated SS showed 98% corrosion inhibition efficiency. Moreover, 99% and 96.6% corrosion protection was observed for PDG-g-PANI-coated MS and SS in 1 M H2SO4 solution. Gravimetric studies revealed that PDG-g-PANI coating can protect MS up to 93% for 14 days in salt solution while 97% corrosion inhibition efficiency was retained for 2 months in open air.
Cytotoxicity and Genotoxicity of Azobenzene-Based Polymeric Nanocarriers for Phototriggered Drug Release and Biomedical Applications
Authors: Londoño-Berrío Maritza , Pérez-Buitrago Sandra , Ortiz-Trujillo Isabel Cristina , Hoyos-Palacio Lina M. , Orozco Luz Yaneth , López Lucelly , Zárate-Triviño Diana G. , Capobianco John A. , Mena-Giraldo Pedro
Published: August 2022

Drug nanoencapsulation increases the availability, pharmacokinetics, and concentration efficiency for therapeutic regimes. Azobenzene light-responsive molecules experience a hydrophobicity change from a polar to an apolar tendency by trans–cis photoisomerization upon UV irradiation. Polymeric photoresponse nanoparticles (PPNPs) based on azobenzene compounds and biopolymers such as chitosan derivatives show prospects of photodelivering drugs into cells with accelerated kinetics, enhancing their therapeutic effect. PPNP biocompatibility studies detect the safe concentrations for their administration and reduce the chance of side effects, improving the effectiveness of a potential treatment. Here, we report on a PPNP biocompatibility evaluation of viability and the first genotoxicity study of azobenzene-based PPNPs. Cell line models from human ventricular cardiomyocytes (RL14), as well as mouse fibroblasts (NIH3T3) as proof of concept, were exposed to different concentrations of azobenzene-based PPNPs and their precursors to evaluate the consequences on mitochondrial metabolism (MTT assay), the number of viable cells (trypan blue exclusion test), and deoxyribonucleic acid (DNA) damage (comet assay). Lethal concentrations of 50 (LC50) of the PPNPs and their precursors were higher than the required drug release and synthesis concentrations. The PPNPs affected the cell membrane at concentrations higher than 2 mg/mL, and lower concentrations exhibited lesser damage to cellular genetic material. An azobenzene derivative functionalized with a biopolymer to assemble PPNPs demonstrated biocompatibility with the evaluated cell lines. The PPNPs encapsulated Nile red and dofetilide separately as model and antiarrhythmic drugs, respectively, and delivered upon UV irradiation, proving the phototriggered drug release concept. Biocompatible PPNPs are a promising technology for fast drug release with high cell interaction opening new opportunities for azobenzene biomedical applications.
Optimization of a New Composite Multicellular Plate Structure in Order to Reduce Weight
Authors: Kovács György
Published: August 2022

Currently, the most important structural design aims are weight reduction, corrosion resistance, high stiffness and vibration damping in several industrial applications, which can be provided by the application of advanced fiber-reinforced plastic (FRP) composites. The main research aim was to develop novel and innovative multicellular plate structures that utilize the benefits of lightweight advanced FRP and aluminum materials, as well as to combine the advantageous characteristics of cellular plates and sandwich structures. Two new multicellular plate structures were developed for the structural element of a transport vehicle. The first structure consists of carbon-fiber-reinforced plastic (CFRP) face sheets and pultruded glass-fiber-reinforced plastic (GFRP) stiffeners. The second structure consists of carbon-fiber-reinforced plastic face sheets and aluminum (Al) stiffeners. The second main goal of this research was the development of an optimization method of minimal weight for the newly developed all-FRP structure and the CFRP-Al structure, considering seven design constraints. The third main purpose was to confirm in a real case study that lightweight multicellular composite constructions, optimized by the flexible tolerance optimization method, provide significant weight saving (86%) compared to the all-steel structure. The added value of the research is that optimization methods were developed for the constructed new composite structures, which can be applied in applications where weight saving is the primary aim.
Heat Stability and Icing Delay on Superhydrophobic Coatings in Facile One Step
Authors: Shang Jingyu , Jiang Yongfeng , Wang Wenhua
Published: August 2022

Superhydrophobic coatings are limited to poor durability and a tedious preparation process. In this work, an efficient, eco-friendly, and cost-effective sol-gel method is developed for preparing superhydrophobic surfaces using an all-in-one suspension composed of methyltrimethoxysilane (MTMS), nano silicon dioxide (SiO2) particles, and micron zinc oxide (ZnO) particles. Superhydrophobic coatings with a contact angle (CA) up to 153.9° and a sliding angle (SA) of about 3.0° are prepared on Q235 steel substrates using MTMS 5 mL, 0.8 g of nano SiO2, and 0.2 g of micron ZnO. The morphology of the superhydrophobic coating is characterized by scanning electron microscopy (SEM), and the surface is covered with a micro- and nano-scaled hierarchical rough structure. A series of tests are conducted, including long-term stability tests and thermostability tests. The CAs are all above 150°, and the SAs are below 6.3°, indicating the excellent static stability of the prepared superhydrophobic coatings. Moreover, the CA of the superhydrophobic coating remains above 152° after 120 h of UV exposure, and the time for a water droplet to freeze on the surface of the superhydrophobic coating is 18 times of the bare Q235 steel, indicating that the superhydrophobic coating exhibits good resistance to UV radiation and icing-delay properties.
The Role of Interfacial Adhesion on the Mechanical Behavior of Thin Metal/Polymer Laminate with Surface Roughness
Authors: Shahmardani Mahdieh , Mohammadi Rafat
Published: August 2022

Metal/polymer laminate has versatile applications in industry due to the essential roles of its constituents in controlling its mechanical behavior. Therefore, efforts to enhance a laminate’s performance should target its mechanical behavior. One of the most influencing features of the mechanical behavior of this type of thin laminate is the interface layer properties. This study concentrates on the mechanical response of thin aluminum (Al) foil deposited on a polymer substrate by calibrating its interfacial layer properties based on available uniaxial tensile tests performed on thin Al/polymer laminate. Then, taking into account the calibrated parameters for the interface layer, which leads to mimicking the real conditions of the laminate, one type of imperfection is introduced as a wavy roughness on the surface of each layer with different amplitudes to investigate its influence on the overall mechanical behavior of the laminate and its failure mode. The results highlighted that the existence of the roughness on the surface of the polymer layer reduces the maximum engineering stress of the laminate more severely compared to other conditions. As the roughness amplitude increases, the maximum stress reduces a lot. The distribution of equivalent plastic strains represents the appearance of the shear bands in the Al layer and an almost uniform distribution for the polymer layer. In the case of existing roughness on each layer, a higher amount of plastic strain accumulation occurs in the middle of the polymer layer and top corners of the thin Al layer. Due to the significant effect of interfacial layer properties to improve the maximum strength of the laminate and its final elongation, a parametric study is performed, taking into account different interfacial properties. The results indicate that laminate behavior with weaker separation properties in the interface layer is mostly unaffected by adopting higher tractions, and no change happens in the case of high separation considering weak tractions.
Assessment of Destructive and Nondestructive Analysis for GGBS Based Geopolymer Concrete and Its Statistical Analysis
Authors: Shilar Fatheali A. , Ganachari Sharanabasava V. , Patil Veerabhadragouda B. , Javed Syed , Khan T M Yunus , Baig Rahmath Ulla
Published: August 2022

Geopolymer is the alternative to current construction material trends. In this paper, an attempt is made to produce a sustainable construction composite material using geopolymer. Ground granulated blast furnace slag (GGBS)-based geopolymer concrete was prepared and tested for different alkaline to binder ratios (A/B). The effect of various temperatures on compressive strength properties was assessed. The cubes were exposed to temperature ranging from 50 to 70 °C for a duration ranging from 2 to 10 h, and the compressive strength of the specimens was analyzed for destructive and non-destructive analysis and tested for 7, 28, and 90 days. The obtained compressive strength (CS) results were analyzed employing the probability plot (PP) curve, distribution overview curve (DOC), probability density function (PDF), Weibull, survival, and hazard function curve. Maximum compressive strength was achieved for the temperature of 70 °C and an A/B of 0.45 for destructive tests and non-destructive tests with 44.6 MPa and 43.56 MPa, respectively, on 90 days of testing. The survival and hazard function curves showed incremental distribution characteristics for 28 and 90 days of testing results with a probability factor ranging from 0.8 to 1.0.
Non-Relativistic Energy Spectra of the Modified Hylleraas Potential and Its Thermodynamic Properties in Arbitrary Dimensions
Authors: Edet Collins Okon , Osang Jonathan E. , Ali Norshamsuri , Agbo Emmanuel Paul , Aljunid Syed Alwee , Endut Rosdisham , Ettah Emmanuel B. , Khordad Reza , Ikot Akpan Ndem , Asjad Muhammad
Published: August 2022

In this study, the solutions of the Schrodinger equation (SE) with modified Hylleraas potential in arbitrary dimensions was obtained using the asymptotic iteration method (AIM) to obtain the energy and wave functions, respectively. The energy equation was used to obtain the thermal properties of this system. The effect of the potential parameters and dimensions on the energy spectra and thermal properties was scrutinized thoroughly. It was found that the aforementioned affects the thermal properties and energy spectra, respectively. In addition, we also computed the numerical energy spectra of the MHP for the first time and discussed it in detail. The results of our study can be applied to molecular physics, chemical physics, etc.