bluuebunny/crossref_metadata_2025 huggingface dataset:
Global deoffshorization and its impact on the national and regional economies of eastern european countries
Authors: Khalatur Svitlana , Radzevicius Gediminas , Velychko Liudmyla , Fesenko Valeriia , Kriuchko Lesia
Published: September 2019

In recent years, deoffshorization is a trend and dozens of countries have already started an open fight against offshore accounts. Ukraine is moving to complete deoffshorization in accordance with the new rules for exchanging information on financial accounts and BEPS rules. The purpose of the study was to search for optimal solutions for further improvements in the field of deoffshorization of the national and regional economy of the Eastern European contries, in particular Ukraine. The following methods were used to solve the problems in the work: induction and deduction (in the study of offshore types, the definition of interconnection and interdependence between them), abstract-logical (in generalizing the theoretical foundations of economic deoffshorization ), econometric-statistical (in assessing the state and dynamics of export-import operations of Ukraine with offshore jurisdictions), statistical analysis.On the basis of theoretical and empirical conclusions, the main consequences, which are the result of the study of global deoffshorization in conditions of financial control and its influence on the national and regional economy of Ukraine, are presented. The article provides a correlation analysis of the dependence of the export index to the UK from Ukraine with export, import and balance of offshore countries. A study was conducted on the presence or absence of a relationship between the volume of balance, exports and imports from Ukraine to the United Kingdom with the macroeconomic indicators of the national economy of Ukraine.
Predicting Purchase Intention toward Halal Packaged Food from Non-Muslim Manufacturers: A Comparative Study of Muslim in Thailand and Indonesia
Authors: Ruangkanjanases Athapol  Ruangkanjanases , Sermsaksopon Tassaya  Sermsaksopon
Published: September 2019

Halal packaged food products have attracted much attention in ASEAN where its largest member, Indonesia, is the world’s most populous Muslim country and is a major market in the region. For non-Muslim country like Thailand, Islam also has significant role being the second popular religion after Buddhism. Although Islamic population in Thailand is not as great as in Islamic countries, Thailand plays a substantial part in halal business as being recognized as a food production base exporting halal food worldwide. Therefore, the major objective of this study is to identify and analyze the significant factors that influence purchase intention of Thai and Indonesian Muslims toward halal packaged food products from non-Muslim manufacturers. This study used a survey to collect data consisting of 200 Thai respondents and 200 Indonesian respondents. The results indicated that product ingredients significantly influenced consumers’ intention to purchase both in Thailand and Indonesia while halal certification only significantly influenced consumers’ intention to purchase in Indonesia.
Gender Stereotype Role in The Business Success of Women Entrepreneurs in Indonesia
Authors: Hartono Hendry  Hartono , Luhur Wella  Luhur , Sasmoko Sasmoko Sasmoko , Juli Setiadi Nugroho  Juli Setiadi , Aziz Abdulah Abdul  Aziz Abdulah
Published: September 2019

Having good business relationships with stakeholders and have innovative behaviours that are competitive, full of challenges, as well as risks to achieve success in the business. In relationships and behaviours, human beings are inseparable from their views on the attributes or characteristics of women and that have to be performed by women and men who are subconsciously embedded and absorbed in each individual's subconscious, which is commonly referred to as gender stereotypes. This is not apart from its influences on business relationships and innovative behaviours of women entrepreneurs in their business to achieve business success. It is interesting to examine whether gender stereotypes are moderate business relationships and innovative behaviours towards the success of women entrepreneur business in Indonesia. Sources of data obtained by distributing questionnaires and interviewing 109 women entrepreneurs. This research is a quantitative research using the Hierarchical Regression Analysis research method. The findings of this study show that women are more likely to have a relationship with women entrepreneurs. Gender stereotype as a moderating variable does not affect business relationships with a moderate relationship between innovative behaviour towards business success in women entrepreneurs in Indonesia, and the result shows gender stereotype decrease the influence of innovative behaviours of women entrepreneurs to the success of their business.
ANOITECE NA CIDADE: DILEMAS E DESAFIOS DO ENSINO MÉDIO NOTURNO EM TEMPOS DE REFORMA
Authors: Simões Willian , Andreis Adriana Maria
Published: September 2019

Neste artigo, debatemos os resultados de uma pesquisa com estudantes (1913), professores (103) e gestores (48) do Ensino Médio (EM) noturno, de escolas públicas estaduais de Chapecó/SC. O objetivo é refletir acerca de dilemas e desafios do Ensino Médio Noturno, em particular, de fatores que influenciam direta ou indiretamente nos índices de evasão/abandono e repetência por parte dos estudantes. Metodologicamente, compreende um diálogo entre referenciais teóricos, especialmente, da área da Educação com os dados empíricos resultantes da pesquisa. Organizamos o texto enfocando a contextualização da problemática, a singularidade do estudo no EM noturno, a relação entre realidade expressada e as reformas educacionais, e encaminhamos apontando questões para debate. A pesquisa indica a necessidade de investimento em formação continuada de gestores e professores, assim como para a melhoria de infraestrutura das escolas, considerando a relação juventude-escola, gestores-professores-jovens, escola-comunidade. Sinaliza, também, que no enfrentamento dos dilemas vividos, a saída não é linear e nem aligeirada por decreto-lei, sob pena de desvio da função educativa, inclusiva e emancipatória, da escola.
REALISMO CRÍTICO E MARXISMO: CONTRIBUIÇÕES À FILOSOFIA DA EDUCAÇÃO MATEMÁTICA
Authors: Wagner Guilherme , Silveira Everaldo
Published: September 2019

O presente artigo procura elucidar pontos nodais do Realismo Crítico com relação as compreensões de verdade científica e progresso da ciência, explicando conceitos chaves como estratificação e emergência da realidade, relativismo epistemológico, ontologia e julgamento racional. Para alcançar tais objetivos fez-se um estudo da primeira fase da obra de Roy Bhaskar, fundador da corrente filosófica, onde percebemos que tal metateoria tem grandes potencialidades para o campo educacional das ciências e da matemática visto seu caráter unificador. Dessas potencialidades apresentaremos o referencial marxista-lukácsiano, e seu método ontológico-genético, como aquele que possibilita uma importante abordagem metodológica na pesquisa em Filosofia da Educação Matemática, estando de acordo com os critérios metateóricos determinados pelo Realismo Crítico.
A INTERCULTURALIDADE NA FORMAÇÃO DOS PROFISSIONAIS DE ENFERMAGEM
Authors: Fontana Rosane Teresinha
Published: September 2019

Trata-se de uma proposta de reflexão sobre a interculturalidade e a formação em enfermagem. Utilizou-se a revisão narrativa como método. Considerando que a intercultura vem se configurando como uma nova perspectiva epistemológica, e, como um objeto de estudo interdisciplinar e transversal, no sentido de tematizar e teorizar a complexidade, entende-se que refletir sobre o tema na formação em enfermagem pode agregar valor ao cuidado. Em todas as áreas do conhecimento, a diversidade cultural só pode ser promovida ao reconhecer, como princípio fundador, o diálogo e o respeito entre as civilizações e as culturas. Além disso, constitui força motriz do desenvolvimento, indispensável para atenuar a pobreza e promover tanto a igualdade como a equidade na assistência à saúde.
O DESENVOLVIMENTO DE ESTRATÉGIAS DE ENSINO PARA A PROMOÇÃO DA SAÚDE NA FORMAÇÃO DOCENTE CONTINUADA
Authors: Visintainer Daniela Sastre Rossi , Soares Félix Alexandre Antunes
Published: September 2019

Como parte integrante de uma pesquisa-ação que investiga a contribuição de oficinas pedagógicas sobre a promoção da saúde na formação docente continuada, este trabalho tem como objetivo analisar o desenvolvimento de estratégias de ensino e aprendizagem contextualizadas com o tema promoção da saúde, a partir da percepção dos professores. Participaram quatorze professoras de diversas áreas dos últimos anos do ensino fundamental de uma escola pública no interior do RS. Para registro de dados, foram utilizados o diário de campo e um questionário online com questões abertas. Como estratégias de ensino e aprendizagem, as docentes desenvolveram três projetos de aprendizagem individuais e um coletivo. Observaram que a contextualização do tema favoreceu o processo de ensino e aprendizagem e a mudança de hábitos em relação à saúde. A principal dificuldade encontrada durante a realização dos projetos foi o tempo restrito, em relação às outras demandas escolares. Consideram que o trabalho interdisciplinar por projetos enriquece a compreensão das relações entre os conteúdos, as interações e relações interpessoais, apesar de apresentar alguns entraves. Por fim, avaliaram as intervenções de pesquisa como positivas em relação às contribuições ao trabalho docente, à cooperação dos pesquisadores e às contribuições aos alunos e à escola.
EDUCAÇÃO EM SAÚDE, MEDIADA POR FILME COMERCIAL, NA FORMAÇÃO DE PROFESSORES DE CIÊNCIAS DA NATUREZA
Authors: Gonçalves dos Santos Eliane , De Araújo Maria Cristina Pansera , De Carvalho Graça Simões
Published: September 2019

As mudanças curriculares, a inserção das novas tecnologias, o contexto social e as condições econômicas e políticas da sociedade moderna afetam o processo de formação de professores. Partindo deste entendimento, este trabalho apresenta análises, discussão e significação da Educação em Saúde (ES), na formação inicial e continuada de professores, com uso do filme comercial “Uma Prova de Amor (EUA, 2009)”. A questão orientadora foi: que aprendizagens em educação em saúde são produzidas na discussão de filmes comerciais, em aulas da educação básica ou superior? Vinte e seis professores de Ciências Biológicas, em formação inicial e continuada, com reuniões formativas sistemáticas, participaram de sete sessões fílmicas. Em cada uma delas, o grupo assistia a um filme e discutia as compreensões de saúde e educação em saúde. As sessões foram audiogravadas, transcritas, lidas e identificados os excertos significativos. A Análise Microgenética das transcrições das discussões produzidas mostrou que o debate e as interações no grupo possibilitaram ampliar e ressignificar o entendimento de saúde numa articulação de aspectos anatômicos, fisiológicos e bioquímicos, sociais, emocionais e ambientais. Além disso, questões como finitude da vida, eutanásia, direito a morte digna e envelhecimento foram contempladas na discussão, ampliando a compreensão da promoção da saúde.
EDUCAÇÃO EM VALORES MORAIS NUMA PERSPECTIVA TRANSDISCIPLINAR
Authors: Skrsypcsak Daniel , Franzen Douglas Orestes
Published: September 2019

Este artigo tem como objetivo refletir sobre a educação em valores morais  numa perspectiva transdisciplinar. Estender essa discussão a partir das instituições que oferecem a educação pública básica nos faz pensar na necessidade de implementação de um projeto institucional tendo como pano de fundo a transdisciplinaridade. A partir de uma revisão bibliográfica trouxemos para o debate autores que se debruçam sobre a temática e que podem contribuir para aprofundar a discussão. Para atender o propósito do trabalho estruturamos o mesmo em três momentos: no primeiro apresentamos algumas considerações em relação à ética sob a perspectiva da complexidade de Edgar Morin. No segundo momento abordamos algumas questões conceituais sobre a transdiciplinaridade tendo em Basarab Nicolescu o principal autor utilizado. No terceiro momento problematizamos como os valores morais podem ser trabalhados na escola pública buscando na transdisciplinaridade uma possibilidade de discussão. Defendemos a possibilidade de elaboração de um projeto institucional em torno da temática onde todas as ações e relações da escola tenham os valores morais explicitados de forma consciente e intencional. Acreditamos que a escola não pode se silenciar para essa questão buscando um consenso sobre determinados valores morais indispensáveis para a formação integral.
APRESENTAÇÂO
Authors: Acadêmico Editores Pensar
Published: September 2019

Revista da Faculdade de Ciências Gerenciais de Manhuaçu – FACIG (ISSN 1808-6136). Pensar Acadêmico, Manhuaçu, MG, v. 13, n. 2, Julho-Dezembro, 2015.
SÍNDROME DA ENDOMETRIOSE TORÁCICA
Authors: Casarin Délcio Aparecido Durso , Baliero José Renato , Louback Filho Houston Da Matta , Mendes Renata Alvim , Viana Pedro Wilson Diniz
Published: September 2019

A síndrome da endometriose pleural é definida pela presença de tecido endometrial pleural ou pulmonar associada a manifestações clínicas de hemoptise, pneumotórax ou derrame pleural de repetição, do tipo catamenial. Na maioria dos pacientes, sua definição se faz por exclusão e diagnóstico presuntivo, sendo considerada uma entidade rara. O diagnóstico se dá com base numa história clínica detalhada, em que a presença dos sintomas catameniais se torna o ponto fundamental para sua elucidação. Os autores apresentam um caso de derrame pleural de repetição por focos de endometriose à luz da revisão de literatura e dos conhecimentos atuais.
Sustainable Conservation of Architectural Heritage. A Case Study of Negova Castle, Slovenia
Authors: Gurnick Nataša Jurgec , Lah Ljubo
Published: September 2019

A more focused and inclusive approach to the conservation of architectural heritage can make a positive cultural, economic and social contribution to the well-being of our society. Architectural heritage has been recognized as a crucial component of sustainable built environment and approaches to conservation of architectural heritage are evolving. The case study of Negova Castle examines the effects of a traditional, object-based approach to conservation of the architectural heritage compared to a reconfigured sustainable approach which supports the importance of sustainable development. Since 2006, the Negova Castle Complex has gone through a thorough restoration process and in 2012 restored buildings were open to the public; the restoration followed traditional object-based conservation practices. The buildings were restored as monuments of the past with little consideration of current social and economic norms. The main building, a 15th century castle, was left untouched due to the lack of financing. The aim of this paper is to provide a brief analysis of the current situation of Negova Castle, to challenge the traditional object-based approach and its criteria for the evaluation of heritage authenticity which was applied to the restored buildings and, subsequently, to identify holistic, sustainable approaches with adaptive reuse strategies suitable for the 15th century castle. By analyzing the Negova Castle project, it becomes evident that it is very hard to protect, preserve and manage the site's architectural heritage for the future without understanding and properly balancing its contemporary and sustained values and without meeting the current social needs. The goal of this study is to propose an approach that addresses the architectural integrity of the Old Castle and to reduce interventions in its fabric while contributing to the greater integration of architectural heritage owners and other stakeholders into the sustainable conservation process and management of the Negova Castle Complex.
Recent Advances in System Based Study for Anti-Malarial Drug Development Process
Authors: Yadav Brijesh S. , Chaturvedi Navaneet , Marina Ninoslav
Published: September 2019

Background:

Presently, malaria is one of the most prevalent and deadly infectious disease across Africa,
Asia, and America that has now started to spread in Europe. Despite large research being carried out in the
field, still, there is a lack of efficient anti-malarial therapeutics. In this paper, we highlight the increasing efforts
that are urgently needed towards the development and discovery of potential antimalarial drugs, which must be
safe and affordable. The new drugs thus mentioned are also able to counter the spread of malaria parasites that
have been resistant to the existing agents.

Objective:

The main objective of the review is to highlight the recent development in the use of system biologybased
approaches towards the design and discovery of novel anti-malarial inhibitors.

Method:

A huge literature survey was performed to gain advance knowledge about the global persistence of
malaria, its available treatment and shortcomings of the available inhibitors. Literature search and depth analysis
were also done to gain insight into the use of system biology in drug discovery and how this approach could be
utilized towards the development of the novel anti-malarial drug.

Results:

The system-based analysis has made easy to understand large scale sequencing data, find candidate
genes expression during malaria disease progression further design of drug molecules those are complementary of
the target proteins in term of shape and configuration.

Conclusion:

The review article focused on the recent computational advances in new generation sequencing,
molecular modeling, and docking related to malaria disease and utilization of the modern system and network
biology approach to antimalarial potential drug discovery and development.
Assessment of Orthodontic Treatment Need in Kosovar Children
Authors: Reshitaj Albena , Reshitaj Krenar , Bytyqi Betina
Published: September 2019

Background:

To date, no survey was done in Kosovo for the identification of orthodontic treatment needs. The aim of this study is to assess the prevalence of orthodontic treatment need among Kosovar children of ages 11-13, using the DAI and the DHC-IOTN in the identification of orthodontic treatment need.

Methods:

A sample of 185 children (50.3% female, 49.7% male), aged between 11-13, was randomly selected from one elementary school in Prishtina. Orthodontic treatment need was measured using the Dental Aesthetic Index (DAI) and the dental health component of the Index of Orthodontic Treatment Need (DHC-IOTN).

Results:

Based on DAI, treatment was found as elective in 11.9 percent of the children. Treatment was found as highly desirable and mandatory in 5.9 percent and 4.3 percent of children, respectively. No gender-based significant differences were noted. According to IOTN DHC: 16.2 percent of children had borderline treatment need, while 66.5 percent had severe and extreme treatment need (grades 4 and 5). Again, no significant gender-based differences in the treatment need were found.

Conclusion:

High prevalence of orthodontic treatment need was identified in Kosovar children of ages 11-13, while no gender-based statistically significant differences were noted in the need for orthodontic treatment.
Uloga Laboratorija za tipizaciju tkiva u povijesnom razvoju transplantacije bubrega u Rijeci
Authors: Katalinić Nataša , Balen Sanja
Published: September 2019

Prva uspješna transplantacija bubrega u Jugoslaviji ostvarena je u Rijeci 30. siječnja 1971. kao rezultat multidisciplinarne suradnje u kojoj su značajni doprinos pružili djelatnici Laboratorija za tipizaciju tkiva, tada bolnice „Dr. Zdravko Kučić“ na Sušaku, a danas Kliničkog bolničkog centra (KBC) u Rijeci. Upravo su intenzivne pripreme za zahvat transplantacije potakle osnivanje prvog Laboratorija za tipizaciju tkiva u Hrvatskoj pri Stanici, kasnije Zavodu za transfuzijsku medicinu. Ovim radom prikazan je utjecaj povijesnog razvoja Laboratorija na uspješnost transplantacijskog programa te postizanje i održavanje statusa riječkog KBC-a kao jednog od vodećih transplantacijskih centara u Hrvatskoj. Temeljem proučavanja povijesnih dokumenata Laboratorija i arhive KBC-a prikazan je razvoj tipizacije tkiva u Rijeci od osnutka Laboratorija 1971. do danas. Opisan je napredak u usvajanju novih metoda tipizacije tkiva u određivanju polimorfizma sustava HLA, probiru seruma pacijenata na prisustvo protutijela HLA i određivanju njihove specifičnosti, te križnih proba u svrhu otkrivanja donor-specifičnih protutijela. Odabir i primjena optimalnih metoda rada u Laboratoriju pridonijela je usvajanju najnovijih spoznaja u transplantacijskoj imunologiji i povijesnom razvoju transplantacijskog programa u Rijeci.
An Electronic Medication Module to Improve Health Literacy in Patients With Type 2 Diabetes Mellitus: Pilot Randomized Controlled Trial
Authors: Seidling Hanna Marita , Mahler Cornelia , Strauß Beate , Weis Aline , Stützle Marion , Krisam Johannes ,   INFOPAT P4/P5 Study Team, Szecsenyi Joachim , Haefeli Walter Emil
Published: September 2019

Background

In primary care, patients play a crucial role in managing care processes and handling drug treatment. A decisive factor for success is their health literacy, and several interventions have been introduced to support patients in fulfilling their responsibility.

Objective

The aim of this study is to assess the influence of such an intervention (ie, a medication module) within a patient-led electronic health record on patients’ health literacy.

Methods

We conducted a randomized controlled study among community-dwelling patients with type 2 diabetes mellitus. Patients were recruited from primary care practices. After randomization, patients either had access to an internet-based medication module allowing them to store their medication information, look up drug information, and print a medication schedule (intervention group), or they received an information brochure on the importance of medication schedules (control group). After 4-8 weeks, all patients were invited to attend a structured medication review (ie, follow-up visit). Data were collected via questionnaires before the start of the intervention and during the follow-up visit. The main outcome measure was the mean difference in health literacy between baseline and follow-up assessments of patients in the control and intervention groups.

Results

Of 116 recruited patients, 107 (92.2%) completed the follow-up assessment and were eligible for intention-to-treat analyses. Only 73 patients, of which 29 were in the intervention group, followed the study protocol and were eligible for per-protocol analysis. No differences in overall health literacy were observed in either the intention-to-treat or in the per-protocol cohorts. Reasons for a null effect might be that the cohort was not particularly enriched with participants with low health literacy, thus precluding measurable improvement (ie, ceiling effect). Moreover, the success of implementation was considered poor because both the correct application of the study procedure (ie, randomization according to the protocol and dropout of 29 patients) and the actual interaction with the medication module was modest (ie, dropout of 9 patients).

Conclusions

The conduct of this randomized controlled study was challenging, leaving it open whether inadequate implementation, too short of a duration, or insufficient efficacy of the intervention, as such, contributed to the null effect of this study. This clearly outlines the value of piloting complex interventions and the accompanying process evaluations.
Performance of Fetal Medicine Foundation Software for Pre-Eclampsia Prediction Upon Marker Customization: Cross-Sectional Study
Authors: Rezende Karina Bilda De Castro , Cunha Antonio José Ledo Alves , Amim Jr Joffre , Oliveira Wescule De Moraes , Leão Maria Eduarda Belloti , Menezes Mariana Oliveira Alves , Jardim Ana Alice Marques Ferraz De Andrade , Bornia Rita Guérios
Published: September 2019

Background

FMF2012 is an algorithm developed by the Fetal Medicine Foundation (FMF) to predict pre-eclampsia on the basis of maternal characteristics combined with biophysical and biochemical markers. Afro-Caribbean ethnicity is the second risk factor, in magnitude, found in populations tested by FMF, which was not confirmed in a Brazilian setting.

Objective

This study aimed to analyze the performance of pre-eclampsia prediction software by customization of maternal ethnicity.

Methods

This was a cross-sectional observational study, with secondary evaluation of data from FMF first trimester screening tests of singleton pregnancies. Risk scores were calculated from maternal characteristics and biophysical markers, and they were presented as the risk for early pre-eclampsia (PE34) and preterm pre-eclampsia (PE37). The following steps were followed: (1) identification of women characterized as black ethnicity; (2) calculation of early and preterm pre-eclampsia risk, reclassifying them as white, which generated a new score; (3) comparison of the proportions of women categorized as high risk between the original and new scores; (4) construction of the receiver operator characteristic curve; (5) calculation of the area under the curve, sensitivity, and false positive rate; and (6) comparison of the area under the curve, sensitivity, and false positive rate of the original with the new risk by chi-square test.

Results

A total of 1531 cases were included in the final sample, with 219 out of 1531 cases (14.30; 95% CI 12.5-16.0) and 182 out of 1531 cases (11.88%; 95% CI 10.3-13.5) classified as high risk for pre-eclampsia development, originally and after recalculating the new risk, respectively. The comparison of FMF2012 predictive model performance between the originally estimated risks and the estimated new risks showed that the difference was not significant for sensitivity and area under the curve, but it was significant for false positive rate.

Conclusions

We conclude that black ethnicity classification of Brazilian pregnant women by the FMF2012 algorithm increases the false positive rate. Suppressing ethnicity effect did not improve the test sensitivity. By modifying demographic characteristics, it is possible to improve some performance aspects of clinical prediction tests.
Exploring the Views of Osteogenesis Imperfecta Caregivers on Internet-Based Technologies: Qualitative Descriptive Study (Preprint)
Authors: Castro Aimee R , Chougui Khadidja , Bilodeau Claudette , Tsimicalis Argerie
Published: September 2019

BACKGROUND

Osteogenesis imperfecta (OI) is a rare genetic condition that can lead to frequent debilitating bone fractures. Family caregivers of children with OI face unique challenges in providing care, which may include limited access to information about the condition, feelings of distress, and experiences of social isolation. Internet-based technologies (IBTs) have been useful for supporting other types of caregivers. However, the views of OI caregivers on IBTs have not been explored.

OBJECTIVE

This study aimed to explore the views of OI caregivers on the uses of IBTs to support them in caring for their children with OI.

METHODS

A qualitative descriptive study was conducted. Caregivers of children with OI were recruited at a pediatric hospital in Montreal, Canada. Interviews were used to explore each caregiver’s views on the applicability of IBTs in supporting their caregiving needs. The interviews were transcribed verbatim and thematically analyzed.

RESULTS

A total of 18 caregivers participated. The caregivers shared that IBTs were useful for facilitating the following activities: daily activities of caregiving (such as providing physical care, supporting relationships, supporting self-care and hope, and managing the logistics of caregiving), OI medical information seeking, and OI social networking. However, they also revealed concerns about the health consequences of IBT use and the quality of IBT content. Concerns regarding IBTs varied somewhat with caregivers’ geographies. Caregivers offered suggestions and strategies for how IBTs can be optimized for caregiving.

CONCLUSIONS

Family caregivers of children with OI face unique challenges in providing care, which may include lacking access to information about the rare condition and feeling socially isolated. OI caregivers use IBTs to overcome some of these challenges and to support their specific caregiving needs. These findings contribute to the paucity of knowledge by offering varied IBT strategies to support caregiving activities, which may be beneficial for other caregivers. Participants’ suggestions for IBT services can inform the development of new resources for OI caregivers and potentially for other caregivers of children living with rare conditions.
Cost-Effectiveness of a Continuous Glucose Monitoring Mobile App for Patients With Type 2 Diabetes Mellitus: Analysis Simulation (Preprint)
Authors: Tsuji Shintaro , Ishikawa Tomoki , Morii Yasuhiro , Zhang Hongjian , Suzuki Teppei , Tanikawa Takumi , Nakaya Jun , Ogasawara Katsuhiko
Published: September 2019

BACKGROUND

Apps for real-time continuous glucose monitoring (CGM) on smartphones and other devices linked to CGM systems have recently been developed, and such CGM apps are also coming into use in Japan. In comparison with conventional retrospective CGM, the use of CGM apps improves patients’ own blood glucose control, which is expected to help slow the progression of type 2 diabetes mellitus (DM) and prevent complications, but the effect of their introduction on medical costs remains unknown.

OBJECTIVE

Our objective in this study was to perform an economic appraisal of CGM apps from the viewpoint of assessing public medical costs associated with type 2 DM, using the probability of developing type 2 DM–associated complications, and data on medical costs and utility value to carry out a medical cost simulation using a Markov model in order to ascertain the cost-effectiveness of the apps.

METHODS

We developed a Markov model with the transition states of insulin therapy, nephrosis, dialysis, and cardiovascular disease, all of which have a major effect on medical costs, to identify changes in medical costs and utility values resulting from the introduction of a CGM app and calculated the incremental cost-effectiveness ratio (ICER).

RESULTS

The ICER for CGM app use was US $33,039/quality-adjusted life year (QALY).

CONCLUSIONS

Sensitivity analyses showed that, with the exception of conditions where the transition probability of insulin therapy, utility value, or increased medical costs increases, the ICER for the introduction of CGM apps was below the threshold of US $43,478/QALY used by the Central Social Insurance Medical Council. Our results provide basic data on the cost-effectiveness of introducing CGM apps, which are currently starting to come into use.
Automatic Work-Hours Recorder for Medical Staff (Staff Hours): Mobile App Development (Preprint)
Authors: Chiang Ting-Wei , Chen Si-Yu , Pan Yuan-Chien , Lin Yu-Hsuan
Published: September 2019

BACKGROUND

There are numerous mobile apps for tracking work hours, but only a few of them record work hours automatically instead of relying on manual logging. No apps have been customized for medical staff, whose work schedules are highly complicated as they have both regular hours and on-call duties.

OBJECTIVE

The specific aims of this study were to (1) identify the Staff Hours app users’ GPS-defined work hours, (2) examine the overtime work hours from the app-recorded total work hours and the participants’ self-reported scheduled work hours, and (3) compare these app-recorded total work hours among different occupations.

METHODS

We developed an app, Staff Hours, to automatically calculate a user’s work hours via GPS background data. Users can enter their scheduled hours, including regular hours and on-call duties. The app automatically generates overtime reports by comparing the app-recorded total work hours with the user-defined scheduled hours. A total of 183 volunteers (60 females and 123 males; mean age 32.98 years, SD 6.74) were included in this study. Most of the participants (162/183, 88.5%) were medical staff, and their positions were resident physicians (n=89), visiting staff (n=38), medical students (n=10), registered nurses (n=25), and non–health care professionals (non-HCPs; n=21).

RESULTS

The total work hours (mean 55.69 hours, SD 21.34) of the 183 participants were significantly higher than their scheduled work hours (mean 50.67 hours, SD 21.44; P=.01). Medical staff had significantly longer total work hours (mean 57.01 hours, SD 21.20) than non-HCPs (mean 45.48 hours, SD 20.08; P=.02). Residents (mean 60.38 hours, SD 18.67) had significantly longer work hours than visiting staff (mean 51.42 hours, SD 20.33; P=.03) and non-HCPs (mean 45.48 hours, SD 20.08; P=.004).

CONCLUSIONS

Staff Hours is the first automatic GPS location–based app designed for medical staff to track work hours and calculate overtime. For medical staff, this app could keep complete and accurate records of work hours in real time, reduce bias, and allow for better complying with labor regulations.
Development and Performance of a Web-Based Tool to Adjust Urine Toxicology Testing Frequency: Retrospective Study (Preprint)
Authors: Chapman Kenneth B , Pas Martijn M , Abrar Diana , Day Wesley , Vissers Kris C , van Helmond Noud
Published: September 2019

BACKGROUND

Several pain management guidelines recommend regular urine drug testing (UDT) in patients who are being treated with chronic opioid analgesic therapy (COAT) to monitor compliance and improve safety. Guidelines also recommend more frequent testing in patients who are at high risk of adverse events related to COAT; however, there is no consensus on how to identify high-risk patients or on the testing frequency that should be used. Using previously described clinical risk factors for UDT results that are inconsistent with the prescribed COAT, we developed a web-based tool to adjust drug testing frequency in patients treated with COAT.

OBJECTIVE

The objective of this study was to evaluate a risk stratification tool, the UDT Randomizer, to adjust UDT frequency in patients treated with COAT.

METHODS

Patients were stratified using an algorithm based on readily available clinical risk factors into categories of presumed low, moderate, high, and high+ risk of presenting with UDT results inconsistent with the prescribed COAT. The algorithm was integrated in a website to facilitate adoption across practice sites. To test the performance of this algorithm, we performed a retrospective analysis of patients treated with COAT between June 2016 and June 2017. The primary outcome was compliance with the prescribed COAT as defined by UDT results consistent with the prescribed COAT.

RESULTS

979 drug tests (867 UDT, 88.6%; 112 oral fluid testing, 11.4%) were performed in 320 patients. An inconsistent drug test result was registered in 76/979 tests (7.8%). The incidences of inconsistent test results across the risk tool categories were 7/160 (4.4%) in the low risk category, 32/349 (9.2%) in the moderate risk category, 28/338 (8.3%) in the high risk category, and 9/132 (6.8%) in the high+ risk category. Generalized estimating equation analysis demonstrated that the moderate risk (odds ratio (OR) 2.1, 95% CI 0.9-5.0; P=.10), high risk (OR 2.0, 95% CI 0.8-5.0; P=.14), and high risk+ (OR 2.0, 95% CI 0.7-5.6; P=.20) categories were associated with a nonsignificantly increased risk of inconsistency vs the low risk category.

CONCLUSIONS

The developed tool stratified patients during individual visits into risk categories of presenting with drug testing results inconsistent with the prescribed COAT; the higher risk categories showed nonsignificantly higher risk compared to the low risk category. Further development of the tool with additional risk factors in a larger cohort may further clarify and enhance its performance.
Low-Burden Mobile Monitoring, Intervention, and Real-Time Analysis Using the Wear-IT Framework: Example and Usability Study (Preprint)
Authors: Brick Timothy R , Mundie James , Weaver Jonathan , Fraleigh Robert , Oravecz Zita
Published: September 2019

BACKGROUND

Mobile health (mHealth) methods often rely on active input from participants, for example, in the form of self-report questionnaires delivered via web or smartphone, to measure health and behavioral indicators and deliver interventions in everyday life settings. For short-term studies or interventions, these techniques are deployed intensively, causing nontrivial participant burden. For cases where the goal is long-term maintenance, limited infrastructure exists to balance information needs with participant constraints. Yet, the increasing precision of passive sensors such as wearable physiology monitors, smartphone-based location history, and internet-of-things devices, in combination with statistical feature selection and adaptive interventions, have begun to make such things possible.

OBJECTIVE

In this paper, we introduced Wear-IT, a smartphone app and cloud framework intended to begin addressing current limitations by allowing researchers to leverage commodity electronics and real-time decision making to optimize the amount of useful data collected while minimizing participant burden.

METHODS

The Wear-IT framework uses real-time decision making to find more optimal tradeoffs between the utility of data collected and the burden placed on participants. Wear-IT integrates a variety of consumer-grade sensors and provides adaptive, personalized, and low-burden monitoring and intervention. Proof of concept examples are illustrated using artificial data. The results of qualitative interviews with users are provided.

RESULTS

Participants provided positive feedback about the ease of use of studies conducted using the Wear-IT framework. Users expressed positivity about their overall experience with the framework and its utility for balancing burden and excitement about future studies that real-time processing will enable.

CONCLUSIONS

The Wear-IT framework uses a combination of passive monitoring, real-time processing, and adaptive assessment and intervention to provide a balance between high-quality data collection and low participant burden. The framework presents an opportunity to deploy adaptive assessment and intervention designs that use real-time processing and provides a platform to study and overcome the challenges of long-term mHealth intervention.
Penyesuaian Dosis Obat Berdasarkan Nilai Kreatinin Klirens pada Pasien Geriatri Rawat Inap di Rsup Dr. Kariadi Semarang, Indonesia
Authors: Haryati Noor , Rahmawati Fita , Wahyono Djoko
Published: September 2019

Pasien geriatri biasanya mengalami multipathology dan polypharmacy yang dapat mengakibatkan munculnya respon yang berlebihan seperti efek samping bahkan efek toksik. Untuk menghindari hal ini diperlukan penyesuaian dosis berbasis farmakokinetika individual. Penelitian ini bertujuan untuk melihat persentase obat yang membutuhkan adjustment dose pada pasien geriatri berdasarkan kreatinin klirens ginjal yang diukur dengan formula Cockroft-Gault dan menganalisa hubungan ketepatan pendosisan dengan outcome clinic. Penelitian dilakukan dengan rancangan cross-sectional dengan pengambilan data secara retrospektif melalui penelusuran data rekam medis pasien geriatri rawat inap yang dirawat di RSUP dr. Kariadi Semarang tahun 2017. Data yang diamati adalah regimen pengobatan, serum kreatinin, outcome clinic dan adverse drug reaction yang terjadi. Selanjutnya dilakukan estimasi kreatinin kliren yang dilanjutkan dengan menilai kesesuaian dosis dengan referensi dan formula Giusti Hayton. Analisis data dilakukan secara deskriptif dan uji Chi-square dengan SPSS untuk menganalisa pengaruh penyesuaian dosis dengan clinical outcome. Hasil penelitian menunjukkan dari 100 rekam medis pasien yang memenuhi inklusi terdapat 99 pasien yang mendapatkan obat dan memerlukan penyesuaian dosis. Pasien yang mendapatkan regimen pengobatan tepat sebesar 73%.  Dari 785 obat yang diresepkan, 353 (44,97%) obat memerlukan penyesuaian dosis. Dari obat-obat yang memerlukan penyesuaian dosis tersebut 322 (91,22 %) sudah tepat dan 31 (8,78 %) belum tepat. Obat-obat yang belum tepat dosis adalah ketorolak injeksi, ranitidin injeksi dan beberapa jenis antibiotik (meropenem injeksi, levofloksasin tablet, dan sefiksim tablet). Tidak ada hubungan yang bermakna antara ketepatan dosis dengan outcome clinic (p=0,289)
“Positionality” and “Performativity”
Authors: Tebaldi Raquel
Published: September 2019

Over the last few decades, educational reforms have been carried out in many different countries with the aim of expanding the concept of literacy in order to respond to challenges posed by the mass media and the new technologies of information and communication technologies and thus was born the concept of media literacy. Even though some activists consider this kind of education a human right, there is still no consensus over its meaning or even over what objectives such educational policy should seek. This paper aims, therefore, to clarify the most important current debates on the area, to emphasize media literacy’s role in improving the quality of people’s political participation in today’s democracies and to highlight important contributions from feminist theories and gender studies in the construction of this concept, such as the concepts of “positionality” (as developed by Linda Alcoff) and of “performativity” (as proposed by Judith Butler).
Political Cartoon in Ecuador
Authors: Vásquez León David
Published: September 2019

Cartoonist Xavier Bonilla and El Universo newspaper were sanctioned in 2014 after publishing a cartoon which, according to the sanction, motivated social agitation and was inaccurate. Against a backdrop of continuous friction between Rafael Correa’s government and private media in Ecuador, the text examines if the sanction created an environment of fear or self-censorship (chilling effect) in other cartoonists in Ecuador. For the analysis, 81 cartoons from three newspapers were monitored and analyzed during the month following the February 23th elections in Ecuador, in which the results were not as favorable for the government as in several previous elections. The results the paper shows signal there is no chilling-effect influencing how cartoonists draw cartoons or how they choose what to draw. On the other hand, it evidences that El Telégrafo, tough a public newspaper, eschews publishing cartoons portraying Correa or members of the majoritarian political party in Ecuador, Alianza País.
INSIGHTS INTO FORMULATION TECHNOLOGIES AND NOVEL STRATEGIES FOR THE DESIGN OF ORALLY DISINTEGRATING DOSAGE FORMS: A COMPREHENSIVE INDUSTRIAL REVIEW
Authors: AGIBA AHMED M. , ELDIN AHMED B.
Published: September 2019

Among the various routes of administration, the oral route remains the most convenient and commonly employed route for drug delivery. The oral conventional drug delivery systems have some drawbacks, such as possibility of gastrointestinal destruction of labile molecules, low absorption of macromolecules, slow onset of action, and unavoidable fluctuation in the concentration of drugs which can either lead to under- or over medication with concomitant adverse effects, especially for drugs with small therapeutic index. Therefore, it became essential to design novel oral drug delivery systems to achieve quick dissolution, absorption, rapid onset of action and reduction of drug dose. Among those novel drug delivery systems are oral disintegrating tablets (ODTs). The purpose of this review article is to report the recent advances in ODT systems with emphasis on their preparations, characterizations and applications.
EFFECT OF HEATING TIME AND HEAT ON THE PHYSICOCHEMICAL AND ANTIOXIDATIVE PROPERTY OF FISH (LABEO ROHITA) SKIN OIL
Authors: GHOSH NABANITA , BHATTACHARYYA DIPAK KUMAR
Published: September 2019

Objective: Determination of oxidative and thermal stability of Labeo rohita skin oil.

Methods: Labeo rohita skin oil was extracted by soxhlet method using n-hexane as solvent. Acid value, Free Fatty Acid content, the Peroxide value of the oil was determined and the same was also determined after heating the oil at 90 °c for 1 hour to check whether the oil is thermally stable or not. Antioxidant activity was determined via Total Phenolic content (TPC), 2, 2-Diphenyl-1-picryl hydrazyl (DPPH) free radical scavenging activity and Ferric Reducing Antioxidant Power (FRAP) assay. Oxidative stability was determined by heating the oil at a constant temperature of 90 °c for 1 hour, 2 hour, 3 hour, and 4 hour. The oil was also heated at 60 °c, 120 °c, and 18 °c for a constant time of 2 h.

Results: Heating increases the scavenging activity of Labeo rohita skin oil as measured by the 2, 2-Diphenyl-1-picryl hydrazyl (DPPH) method. Total phenolic content (TPC) value and Ferric reducing antioxidant power (FRAP) assay value is decreased both with an increase in heating time (**p<0.05) and heating temperature (p<0.01). Acid value and FFA (Free Fatty Acid) content and Peroxide value is increased with an increase in temperature (**p<0.01)

Conclusion: The Present study explores that Labeo rohita skin oil both thermally and oxidatively stable The results indicate that the oil can be used in food formulation as well as a new cooking oil substitute.
SYNTHESIS AND UTILITY OF NEW POLYCYCLIC COMPOUNDS AS POTENTIAL ANTIMICROBIALS BASED ON CHROMENE MOIETY
Authors: N. ABDELAZIZ MAHMOUD , S. ZARIE EMAN , SARHAN ALAADIN E.
Published: September 2019

Objective: The present research aims to synthesize some new polycyclic compounds including chromene moiety and study their antimicrobial activity.

Methods: Several new polycyclic systems including chromene scaffold incorporated with pyridine, pyrimidine, imidazopyrimidine, and imidazodiazocine were achieved via condensation reaction of chromene derivative under the proper condition with various reagents namely; cyanothioacetamide, phenyl isothiocyanate, malononitrile, carbon disulfide, benzaldehyde, triethylorthoformate, and 1,4-dichlorobutane. Moreover, a chlorodiazenyl chromene derivative was reacted with some substances possessing active–CH2-bridge such as ethyl cyanoacetate and malononitrile to end up with hydrazono compounds. Such compounds were eventually cyclized with hydrazine hydrate to form pyrazole and oxopyrazole derivatives. Moreover, compound 1 was treated with benzoyl acetone, and then followed by cyclization with malononitrile to provide the corresponding 2-amino14-(4-methoxyphenyl)-4-methy-5-phenyl-14H-benzo[5,6] chromeno[2,3H][1,6]naphthyridine-3-carbonitrile (20).

Results: The results of the antimicrobial screening in vitro revealed that the inhibition zone (mm) of the synthesized compounds 1-3, 5 and 8 implied their optimum antibacterial activity, while the compounds 4, 6 and 9-13, 15 showed a moderate to weak antibacterial activity against multiple species of B. subtilis, S. aureus, E. coli and P. aeruginosa. In contrast, the compounds 1, 6, 11, 15 showed high antifungal activities against different species of A. flavinand C. albicans, while the other compounds exhibit a moderate to poor antifungal activity.

Conclusion: It is remarkable that a series of chromene derivatives synthesized by a simple and available method leads to a molecule of promising antimicrobial activity. Further research is recommended to approve the importance of polycyclic systems for various applications.