bluuebunny/crossref_metadata_2025 huggingface dataset:
Deep Infiltrating Endometriosis Malignant Invasion of Cervical Wall and Rectal Wall With Lynch Syndrome： A Rare Case Report and Review of Literature
Authors: Li Baoxuan , Wang Yang , Wang Yue , Li Siman , Liu Kuiran
Published: March 2022

Background

Malignant transformation of deep infiltrating endometriosis (DIE) invading the cervix and rectum is quite rare, especially in patients combined with Lynch syndrome (LS). We report a rare case of a 49-year-old perimenopausal woman with endometrioid carcinoma arising from the pouch of Douglas, invading the cervix and rectum 1 year after a unilateral salpingo-oophorectomy treatment for ovarian endometriosis. The genetic testing of the patient showed germline mutations in MSH2, which combined with the special family history of colorectal cancer of the patient, was also thought to be associated with LS. We have analyzed the reported cases of DIE malignant transformation over the last 10 years, and reviewed the relevant literature, in order to strengthen the clinical management of patients with endometriosis, particularly patients with DIE, and reveal a possible correlation between malignant transformation of endometriosis and LS.

Case Presentation

A 49-year-old perimenopausal woman presented with hypogastralgia, diarrhea, and intermittent fever for more than 1 month. A Transvaginal ultrasound (TVS) showed a cervix isthmus mass, and a magnetic resonance imaging (MRI) showed a mass in pouch of Douglas with high suspicion of malignancy, possibly invading the anterior wall of the rectum. Prior to surgery, the patient performed the ultrasound guided pelvic mass biopsy through the vagina, and the pathology of the mass showed endometrioid carcinoma. The patient received a gynecological–surgical laparotomy and enterostomy, and a histopathology revealed endometrioid carcinoma infiltrating the cervical wall and rectal wall. In the family genetic history of the patient, her mother and two sisters suffered from colorectal cancer, so lesion tissue and blood were taken for genetic testing, which showed a germline mutation in MSH2, with LS being considered. After the surgical treatment, the patient received six courses of paclitaxel–carboplatin chemotherapy. During the course of treatment, bone marrow suppression occurred, but was healed after symptomatic treatment. To date, the patient is generally in good health, and imaging examination showed no evidence of recurrence.

Conclusion

The risk of malignant transformation of endometriosis is increased in perimenopause and postmenopause, as DIE is a rare malignant transformation of endometriosis. DIE can invade other adjacent organs and cause poor prognosis, thus, comprehensive gynecological–surgical treatment should be necessary. In addition, if histopathology showed endometrioid carcinoma, the possibility of LS should be considered, and if necessary, immunohistochemical staining and gene detection should be improved to provide follow-up targeted therapy and immunotherapy.
Reliability of Interleukin-6 Alone and in Combination for Diagnosis of Early Onset Neonatal Sepsis: Systematic Review
Authors: Eichberger Julia , Resch Bernhard
Published: March 2022

Neonatal sepsis is a major cause of morbidity and mortality in both preterm and term infants. Early-onset neonatal sepsis (EONS) presents within the first 72 h of life. Diagnosis is difficult as signs and symptoms are non-specific, and inflammatory markers are widely used to confirm or rule out neonatal sepsis. Interleukin-6 (IL-6) is part of the fetal inflammatory response syndrome (FIRS) and therefore an interesting early marker for neonatal sepsis. The main objective for this review was to assess the diagnostic potential of IL-6, alone and in combination, for diagnosis of early neonatal sepsis (EONS) in term and preterm infants, in cord and peripheral blood, and in dependence of timing of sample collection. IL-6 diagnostic accuracy studies for diagnosing EONS published between 1990 and 2020 were retrieved using the PubMed database. We included 31 out of 204 articles evaluating the potential of IL-6 for the diagnosis of EONS in a study population of newborns with culture-proven and/or clinically suspected sepsis. We excluded articles dealing with neonatal bacterial infections other than sepsis and biomarkers other than inflammatory markers, those written in languages other than English or German, studies that did not distinguish between EONS and late-onset sepsis, and animal and in vitro studies. Full-text articles were checked for other relevant studies according to the PRISMA criteria. We identified 31 studies on IL-6 diagnostic accuracy for EONS diagnosis between 1990 and 2020 including a total of 3,276 infants. Sensitivity and specificity were reported, and subgroup analysis was performed. A STARD checklist adapted for neonates with neonatal sepsis was used for quality assessment. The range of IL-6 sensitivity and specificity in neonatal samples was 42.1–100% and 43–100%; the median values were 83 and 83.3%, respectively. IL-6 accuracy was better in preterm infants than in mixed-study populations. Early sample collection at the time of sepsis suspicion had the highest sensitivity when compared to other time points. Cord blood IL-6 had higher diagnostic value compared to peripheral blood. The biomarker combination of IL-6 and CRP was found to be highly sensitive, but poorly specific. Limitations of this review include use of only one database and inclusion of a heterogeneous group of studies and a small number of studies looking at biomarker combinations; a strength of this review is its focus on early-onset sepsis, since type of sepsis was identified as a significant source of heterogeneity in IL-6 diagnostic accuracy studies. We concluded that IL-6 has a good performance as an early diagnostic marker of EONS within a study population of preterm infants, with best results for cord blood IL-6 using cutoff values above 30 pg/ml.
Bispecific Antibodies Progression in Malignant Melanoma
Authors: Tang Juan , Gong Youling , Ma Xuelei
Published: March 2022

The discovery of oncogenes and immune checkpoints has revolutionized the treatment of melanoma in the past 10 years. However, the current PD-L1 checkpoints lack specificity for tumors and target normal cells expressing PD-L1, thus reducing the efficacy on malignant melanoma and increasing the side effects. In addition, the treatment options for primary or secondary drug-resistant melanoma are limited. Bispecific antibodies bind tumor cells and immune cells by simultaneously targeting two antigens, enhancing the anti-tumor targeting effect and cytotoxicity and reducing drug-resistance in malignant melanoma, thus representing an emerging strategy to improve the clinical efficacy. This review focused on the treatment of malignant melanoma by bispecific antibodies and summarized the effective results of the experiments that have been conducted, also discussing the different aspects of these therapies. The role of the melanoma epitopes, immune cell activation, cell death and cytotoxicity induced by bispecific antibodies were evaluated in the clinical or preclinical stage, as these therapies appear to be the most suitable in the treatment of malignant melanoma.
Mixed-Resolution High-Q Sensor Based on Hybridized Spoof Localized Surface Plasmons
Authors: Wang Jiangpeng , Zhang Jingjing , Gao Hao , Fu Xiaojian , Bao Di , Cui Tie Jun
Published: March 2022

Spoof localized surface plasmons (LSPs) have proven significant advantages in sensing and detection. In this work, we propose a high-Q-factor and high-sensitivity hybridized spoof LSP sensor and a mixed-resolution algorithm. The sensor consists of two concentric inner and outer LSP structures with corrugated rings coupled to each other. The achieved Q-factor is up to 178, and the sensing figure of merit (FoM) is up to 30. Moreover, a mixed-resolution algorithm, combined with multiple resonant peaks, is proposed to enhance the Q-factor and sensing FoM. This algorithm doubles the Q-factor and sensing FoM effectively. This mixed-resolution sensor has a wide range of application prospects in the field of high-frequency on-chip resonators and sensors.
Detecting Intra-Field Variation in Rice Yield With Unmanned Aerial Vehicle Imagery and Deep Learning
Authors: Bellis Emily S. , Hashem Ahmed A. , Causey Jason L. , Runkle Benjamin R. K. , Moreno-García Beatriz , Burns Brayden W. , Green V. Steven , Burcham Timothy N. , Reba Michele L. , Huang Xiuzhen
Published: March 2022

Unmanned aerial vehicles (UAVs) equipped with multispectral sensors offer high spatial and temporal resolution imagery for monitoring crop stress at early stages of development. Analysis of UAV-derived data with advanced machine learning models could improve real-time management in agricultural systems, but guidance for this integration is currently limited. Here we compare two deep learning-based strategies for early warning detection of crop stress, using multitemporal imagery throughout the growing season to predict field-scale yield in irrigated rice in eastern Arkansas. Both deep learning strategies showed improvements upon traditional statistical learning approaches including linear regression and gradient boosted decision trees. First, we explicitly accounted for variation across developmental stages using a 3D convolutional neural network (CNN) architecture that captures both spatial and temporal dimensions of UAV images from multiple time points throughout one growing season. 3D-CNNs achieved low prediction error on the test set, with a Root Mean Squared Error (RMSE) of 8.8% of the mean yield. For the second strategy, a 2D-CNN, we considered only spatial relationships among pixels for image features acquired during a single flyover. 2D-CNNs trained on images from a single day were most accurate when images were taken during booting stage or later, with RMSE ranging from 7.4 to 8.2% of the mean yield. A primary benefit of convolutional autoencoder-like models (based on analyses of prediction maps and feature importance) is the spatial denoising effect that corrects yield predictions for individual pixels based on the values of vegetation index and thermal features for nearby pixels. Our results highlight the promise of convolutional autoencoders for UAV-based yield prediction in rice.
miR160: An Indispensable Regulator in Plant
Authors: Hao Kai , Wang Yun , Zhu Zhanpin , Wu Yu , Chen Ruibing , Zhang Lei
Published: March 2022

MicroRNAs (miRNA), recognized as crucial regulators of gene expression at the posttranscriptional level, have been found to be involved in the biological processes of plants. Some miRNAs are up- or down-regulated during plant development, stress response, and secondary metabolism. Over the past few years, it has been proved that miR160 is directly related to the developments of different tissues and organs in multifarious species, as well as plant–environment interactions. This review highlights the recent progress on the contributions of the miR160-ARF module to important traits of plants and the role of miR160-centered gene regulatory network in coordinating growth with endogenous and environmental factors. The manipulation of miR160-guided gene regulation may provide a new method to engineer plants with improved adaptability and yield.
What Makes a Customer Brand Citizen in Restaurant Industry
Authors: Han Hua , Yang Yi-Chun , Kuang Tingyue , Song Hemin
Published: March 2022

Due to the crucial role of customers’ brand citizenship behaviors on brand strength, this study explored the relationship between brand uniqueness, brand credibility, brand intimacy, brand love, and brand citizenship behavior in Taiwan’s restaurant context. The participants are the customers of Wang Steak, a famous restaurant chain in Taiwan. A total of 358 valid responses were gathered from a questionnaire survey, with a response rate of 71.6%. We used structural equation modeling to analyze the data. Brand uniqueness, brand credibility, and brand intimacy all have a positive relationship with brand love. Moreover, brand love was positively associated with brand citizenship behavior. The findings provide greater insights into the relationship of perceived brand uniqueness, brand credibility, brand intimacy, and brand love with customers’ brand citizenship behaviors.
Relationships Between Job Stress, Psychological Adaptation and Internet Gaming Disorder Among Migrant Factory Workers in China: The Mediation Role of Negative Affective States
Authors: Cao He , Zhang Kechun , Ye Danhua , Cai Yong , Cao Bolin , Chen Yaqi , Hu Tian , Chen Dahui , Li Linghua , Wu Shaomin , Zou Huachun , Wang Zixin , Yang Xue
Published: March 2022

Factory workers make up a large proportion of China’s internal migrants and may be highly susceptible to job and adaptation stress, negative affective states (e.g., depression and anxiety), and Internet gaming disorder (IGD). This cross-sectional study investigated the relationships between job stress, psychological adaptation, negative affective states and IGD among 1,805 factory workers recruited by stratified multi-stage sampling between October and December 2019. Structural equation modeling (SEM) was conducted to test the proposed mediation model. Among the participants, 67.3% were male and 71.7% were aged 35 years old or below. The prevalence of probable depression, probable anxiety, and IGD was 39.3, 28.7, and 7.5%. Being male, younger age, and shorter duration of living in Shenzhen were associated with higher IGD scores. Job stress was significantly associated with IGD (β = 0.11,p= 0.01) but not with negative affective states (β = 0.01,p= 0.77). Psychological adaptation was significantly associated with negative affective states (β = −0.37,p< 0.001) but not with IGD (β = 0.09,p> 0.05). Negative affective states were positively associated with IGD (β = 0.27,p< 0.001). The indirect effect of psychological adaptation (β = −0.10,p= 0.004) but not job stress (β = 0.003,p= 0.77) on IGD through negative affective states was statistically significant. The observed psychological correlates and mechanisms are modifiable, and can inform the design of evidence-based prevention programs for depression, anxiety, and IGD in this population.
Examining Monetary Valuation Methods to Analyze Residents' Social Value From Hosting a Publicly-Funded Major Sport Event
Authors: Bakhsh Jordan T. , Taks Marijke , Parent Milena M.
Published: March 2022

Measuring residents' social value from hosting major sport events has become a popular practitioner and researcher focus. However, researchers have used a plethora of monetary valuation methods to measure social value on an equally diverse set of events. Rather than being applied to major sport events, the use of these methods in sport research has been limited to smaller events, programs, or facilities. Consequently, investigating monetary valuation methods for major sport events is necessary to inform practitioners and researchers of these types of events as to which tool(s) to use. Thus, the purpose of this study was to investigate various monetary valuation methods to determine which method(s) is(are) best to examine residents' social value in a post-event context and test the selected method(s) for the 2010 Olympic Winter Games in Vancouver, Canada. After reviewing monetary valuation methods found in the sport management literature, two methods were deemed suitable avenues to pursue: the reverse contingent valuation method and the opportunity cost approach. This study employed an exploratory sequential mixed methods design to derive a conceptual and empirical analysis. Interviews were conducted with 14 Vancouver residents and supplemented with document analysis; as well, 525 Vancouver residents completed a self-administered online survey. Findings highlighted the importance of using both the reverse contingent valuation method and opportunity cost approach given their complementary nature. The reverse contingent valuation method allowed residents to select how much they valued their experience. This individual or micro-economic perspective is a necessary prerequisite for residents to adequately determine their value of hosting in relation to other options (e.g., building hospitals, having professional sport teams) when applying the opportunity cost approach, which asks residents to reflect at societal or macro-economic level. This synergistic approach demonstrates the importance of addressing both perspectives: the micro (i.e., individual exchange) and the macro (i.e., event exchange) aspect. In doing so, this approach offers researchers and practitioners avenues forward to examine the social value of publicly-funded major sport events exclusively through a direct, an indirect, and a synergistic method to advance the examination of major sport events' social value.
Multiple Technologies Combined to Analyze the Changes of Odor and Taste in Daokou Braised Chicken during Processing
Authors: Zhan Feili , Sun Lingxia , Zhao Gaiming , Li Miaoyun , Zhu Chaozhi
Published: March 2022

This study analyzed the changes of odor and taste in Daokou braised chicken during processing by GC-MS, GC-IMS, e-nose and e-tongue. The 75 and 55 volatile compounds identified in Daokou braised chicken by GC-MS and GC-IMS, respectively, included hydrocarbons, aldehydes, alcohols, terpenes, ketones, heterocyclics, esters, acids and phenols; among them, aldehydes, alcohols and ketones were the most abundant. The number and proportion of volatile compounds in Daokou braised chicken changed significantly (p < 0.05) in the process. The proportion of volatile compounds with animal fatty odor, such as aldehydes and alcohols, decreased, while that of esters, ketones and terpenes from spices with fruity fragrance increased, especially in the braising stage. An e-nose showed that the odor intensities of sulfur-containing and nitrogen oxide compounds were higher (p < 0.05) after the braising stage, but weakened after 2 h braising. An e-tongue showed that saltiness and richness increased significantly (p < 0.05) after braising. The results of these four techniques showed that braising promoted the release of flavor compounds, and was beneficial to salt penetration and umami release. However, long braising could lead to weakened flavor intensity and the introduction of bitterness and astringency. This study also found that GC-IMS and e-nose were more sensitive to trace compounds such as sulfur-containing and nitrogen oxide compounds, esters, acids and phenolics in Daokou braised chicken than GC-MS. The use of multiple technologies could provide more comprehensive flavor profiles for Daokou braised chicken during processing. This study provides insights into the control of flavor of Daokou braised chicken, and may be of practical relevance for the poultry industry.
Review-Hysteresis in Carbon Nano-Structure Field Effect Transistor
Authors: Lu Yu-Xuan , Lin Chih-Ting , Tsai Ming-Hsui , Lin Kuan-Chou
Published: March 2022

In recent decades, the research of nano-structure devices (e.g., carbon nanotube and graphene) has experienced rapid growth. These materials have supreme electronic, thermal, optical and mechanical properties and have received widespread concern in different fields. It is worth noting that gate hysteresis behavior of field effect transistors can always be found in ambient conditions, which may influence the transmission appearance. Many researchers have put forward various views on this question. Here, we summarize and discuss the mechanisms behind hysteresis, different influencing factors and improvement methods which help decrease or eliminate unevenness and asymmetry.
Insights on the Synthesis of N-Heterocycles Containing Macrocycles and Their Complexion and Biological Properties
Authors: Malek Fouad , Harit Tarik , Cherfi Mounir , Kim Bonglee
Published: March 2022

Macrocyclic chemistry has been extensively developed over the past several decades. In fact, the architecture of new macrocyclic models has undergone exponential growth to offer molecules with specific properties. In this context, an attempt is made in this study to provide an overview of some synthetic methods allowing the elaboration of N-heterocycles containing macrocycles (imidazole, triazole, tetrazole, and pyrazole), as well as their applications in the complexation of metal cations or as pharmacological agents.
Isolation of a Melanoblast Stimulator from Dimocarpus longan, Its Structural Modification, and Structure–Activity Relationships for Vitiligo
Authors: Song Jae-Won , Choi Sunju , Kim Gayeong , Lee Hyang Bok , Rao P. Sankara , Shin Jeonghyun , Kim Eun Ki , Cho Dong-Gyu
Published: March 2022

A novel melanoblast stimulator (1) was isolated from Dimocarpus longan. Its analogs were also synthesized to support a new furan-based melanoblast stimulator scaffold for treating vitiligo. Isolated 5-(hydroxymethyl)furfural (HMF, 1) is a well-known compound in the food industry. Surprisingly, the melanogenic activity of HMF (1) was discovered here for the first time. Both HMF and its synthetic analog (16) promote the differentiation and migration of melanoblasts in vitro. Typically, stimulator (1) upregulated MMP2 expression, which promoted the migration of melanoblasts in vitro.
Design, Synthesis and Bioactivity Evaluation of Coumarin–BMT Hybrids as New Acetylcholinesterase Inhibitors
Authors: Zeng Fanxin , Lu Tao , Wang Jie , Nie Xuliang , Xiong Wanming , Yin Zhongping , Peng Dayong
Published: March 2022

Coumarin possesses the aromatic group and showed plentiful activities, such as antioxidant, preventing asthma and antisepsis. In addition, coumarin derivatives usually possess good solubility, low cytotoxicity and excellent cell permeability. In our study, we synthesized the compound bridge methylene tacrine (BMT), which has the classical pharmacophore structure of Tacrine (THA). Based on the principle of active substructure splicing, BMT was used as a lead compound and synthesized coumarin–BMT hybrids by introducing coumarin to BMT. In this work, 21 novel hybrids of BMT and coumarin were synthesized and evaluated for their inhibitory activity on AChE. All obtained compounds present preferable inhibition. Compound 8b was the most active compound, with the value of Ki as 49.2 nM, which was higher than Galantamine (GAL) and lower than THA. The result of molecular docking showed that the highest binding free energy was −40.43 kcal/mol for compound 8b, which was an identical trend with the calculated Ki.
Oligoorganogermanes: Interplay between Aryl and Trimethylsilyl Substituents
Authors: Zaitsev Kirill V. , Poleshchuk Oleg Kh. , Churakov Andrei V.
Published: March 2022

Derivatives of main group elements containing element–element bonds are characterized by unique properties due to σ-conjugation, which is an attractive subject for investigation. A novel series of digermanes, Ar3Ge-Ge(SiMe3)3, containing aryl (Ar = p-C6H4Me (1), p-C6H4F (2), C6F5 (3)) and trimethylsilyl substituents, was synthesized by the reaction of germyl potassium salt, [(Me3Si)3GeK*THF], with triarylchlorogermanes, Ar3GeCl. The optical and electronic properties of such substituted oligoorganogermanes were investigated spectroscopically by UV/vis absorption spectroscopy and theoretically by DFT calculations. The molecular structures of compounds 1 and 2 were studied by XRD analysis. Conjugation between all structural fragments (Ge-Ge, Ge-Si, Ge-Ar, where Ar is an electron-donating or withdrawing group) was found to affect the properties.
Synthesis and Performance of Double-Chain Quaternary Ammonium Salt Glucosamide Surfactants
Authors: Zhi Lifei , Shi Xiufang , Zhang Erzhuang , Gao Chuangji , Gai Haocheng , Wang Hui , Liu Zhenmin , Zhang Tieming
Published: March 2022

A series of double-chain quaternary ammonium salt surfactants N-[N′[3-(gluconamide)] propyl-N′-alkyl]propyl-N,N-dimethyl-N-alkyl ammonium bromide (CnDDGPB, where n represents a hydrocarbon chain length of 8, 10, 12, 14 and 16) were successfully synthesized from D (+)-glucose δ-lactone, N,N-dimethyldipropylenetriamine, and bromoalkane using a two-step method consisting of a proamine-ester reaction and postquaternization. Their surface activity, adsorption, and aggregation behavior in aqueous solution were investigated via measurements of dynamic/static surface tension, contact angle, dynamic light scattering, and transmission electron microscopy. An analysis of their application performance in terms of wettability, emulsifying properties, toxicity, and antibacterial properties was conducted. The results show that with increasing the carbon chain length of the CnDDGPB surfactants, their critical micelle concentration (CMC) increased and the pC20 and efficiency in the interface adsorption of the target product gradually decreased. Moreover, the influence of the hydrophobic carbon chain length on the surface of polytetrafluoroethylene (PTFE) was even greater for the wetting effect, reducing the contact angle to 32° within the length range of C8–C14. The results of the contact angle change and the wettability experiments proved that C10DDGPB exhibited the best wettability. The liquid paraffin and soybean oil emulsification ability of CnDDGPB showed an upward trend followed by a downward trend with the growth of the carbon chain, with C12DDGPB exhibiting the best emulsification performance. The Dlong/Dshort ratio was far lower than 1, which indicates mixed-kinetic adsorption. The surfactants formed spherical micelles and showed a unique aggregation behavior in aqueous solution, which showed an increase–decrease–increase trend with the change in concentration. A cell toxicity and acute oral toxicity experiment showed that the CnDDGPB surfactants were less toxic than the commonly used surfactant dodecyldimethylbenzyl ammonium chloride (1227). In addition, at a concentration of 150 ppm, CnDDGPB exhibited the same bacteriostatic effect as 1227 at a concentration of 100 ppm. The results demonstrate that sugar-based amide cationic surfactants are promising as environmentally friendly disinfection products.
Effect of Thermal and Non-Thermal Technologies on Kinetics and the Main Quality Parameters of Red Bell Pepper Dried with Convective and Microwave–Convective Methods
Authors: Rybak Katarzyna , Wiktor Artur , Kaveh Mohammad , Dadan Magdalena , Witrowa-Rajchert Dorota , Nowacka Małgorzata
Published: March 2022

The drying process preserves the surplus of perishable food. However, to obtain a good-quality final product, different pretreatments are conducted before drying. Thus, the aim of the study was the evaluation of the effect of thermal (blanching treatments with hot water) and non-thermal technologies (pulsed electric field (PEF) and ultrasound (US)) on the kinetics of the drying process of red bell pepper. The convective and microwave–convective drying were compared based on quality parameters, such as physical (water activity, porosity, rehydration rate, and color) and chemical properties (total phenolic content, total carotenoids content, antioxidant activity, and total sugars content). The results showed that all of the investigated methods reduced drying time. However, the most effective was blanching, followed by PEF and US treatment, regardless of the drying technique. Non-thermal methods allowed for better preservation of bioactive compounds, such as vitamin C in the range of 8.2% to 22.5% or total carotenoid content in the range of 0.4% to 48%, in comparison to untreated dried material. Moreover, PEF-treated red bell peppers exhibited superior antioxidant activity (higher of about 15.2–30.8%) when compared to untreated dried samples, whereas sonication decreased the free radical scavenging potential by ca. 10%. In most cases, the pretreatment influenced the physical properties, such as porosity, color, or rehydration properties. Samples subjected to PEF and US treatment and dried by using a microwave-assisted method exhibited a significantly higher porosity of 2–4 folds in comparison to untreated material; this result was also confirmed by visual inspection of microtomography scans. Among tested methods, blanched samples had the most similar optical properties to untreated materials; however non-thermally treated bell peppers exhibited the highest saturation of the color.
Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint
Authors: Islam Md. Rezaul , Islam Fahadul , Nafady Mohamed H. , Akter Muniya , Mitra Saikat , Das Rajib , Urmee Humaira , Shohag Sheikh , Akter Aklima , Chidambaram Kumarappan , Alhumaydhi Fahad A. , Emran Talha Bin , Cavalu Simona
Published: March 2022

Breast cancer (BrCa) is the most common malignancy in women and the second most significant cause of death from cancer. BrCa is one of the most challenging malignancies to treat, and it accounts for a large percentage of cancer-related deaths. The number of cases requiring more effective BrCa therapy has increased dramatically. Scientists are looking for more productive agents, such as organic combinations, for BrCa prevention and treatment because most chemotherapeutic agents are linked to cancer metastasis, the resistance of the drugs, and side effects. Natural compounds produced by living organisms promote apoptosis and inhibit metastasis, slowing the spread of cancer. As a result, these compounds may delay the spread of BrCa, enhancing survival rates and reducing the number of deaths caused by BrCa. Several natural compounds inhibit BrCa production while lowering cancer cell proliferation and triggering cell death. Natural compounds, in addition to therapeutic approaches, are efficient and potential agents for treating BrCa. This review highlights the natural compounds demonstrated in various studies to have anticancer properties in BrCa cells. Future research into biological anti-BrCa agents may pave the way for a new era in BrCa treatment, with natural anti-BrCa drugs playing a key role in improving BrCa patient survival rates.
Spinal arachnoid cysts: modern principles of diagnosis and treatment
Authors:   FBHI «Privolzhsky District Medical Center», Nizhny Novgorod, Yarikov Anton Viktorovich , Shpagin Maksim Vladimirovich ,   SBHI NR «City Clinical Hospital No. 39», Nizhny Novgorod, Perlmutter Olga Aleksandrovna ,   Federal State Budgetary Educational Institution of Higher Education «Privolzhsky Research Medical University», Nizhny Novgorod, Fraerman Alexander Petrovich ,   Federal State Budgetary Educational Institution of Higher Education «Volga Research Medical University», Smirnov Pavel Vasilievich ,   City Clinical Hospital No. 39, Nizhny Novgorod, Kalinkin Aleksandr Aleksandrovich ,   FBUZ «Federal Siberian Scientific and Clinical Center» of the Federal Medical and Biological Agency», Krasnoyarsk
Published: March 2022

The article is devoted to spinal arachnoid cysts. Theories of their origin and clinical picture of this pathology are presented. The classifications of spinal arachnoid cysts are presented in detail. Further, the paper outlines modern methods for the diagnosis and treatment of arachnoid cysts, depending on the classification.
Changes in laboratory parameters of lipid metabolism in HIV patients with cerebral stroke
Authors:   FSBEI HE Tyumen State Medical University of the Ministry of Health of Russia, SBHI TR Regional Hospital No. 3 , Tobolsk, Russia, Tarasov Dmitriy Olegovich , Lebedev Ilya Arkadievich ,   Faculty of Pediatrics, FSBEI HE Tyumen State Medical University of the Ministry of Health of Russia, Suplotov Sergey Nikolaevich ,   FSBEI HE Tyumen State Medical University of the Ministry of Health of Russia, Nesterova Olga Andreevna ,   FSBEI HE Tyumen State University, Boldyreva Yuliya Viktorovna ,   FSBEI HE Tyumen State Medical University of the Ministry of Health of Russia, Tersenov Aleksandr Orestovich ,   FSBEI HE Tyumen State Medical University of the Ministry of Health of Russia
Published: March 2022

The article reflects the results of assessing the state of the blood lipid spectrum in HIV-positive patients with various types of stroke. Objective: to study laboratory parameters of lipid metabolism in patients with cerebral stroke against the background of HIV infection. Materials and methods. We examined 77 patients with ischemic and 32 patients with hemorrhagic stroke against the background of comorbid HIV infection, who received treatment in hospitals in the Tyumen Region. The study of lipid metabolism parameters was carried out on the Beckman Coulter AU480 analyzer (USA). Blood sampling was carried out on the day of the patients’ admission. The control group consisted of 116 patients. The significance of differences was determined at a two-tailed significance level of p<0.05. Results. The study found lower levels of total cholesterol and low-density lipoproteins in the patients with ischemic stroke against the background of HIV infection. In the patients with hemorrhagic stroke, only a decrease in the level of total cholesterol was noted. Conclusions. The state of the plasma lipid spectrum in patients with HIV infections and ischemic stroke, in comparison with those with hemorrhagic stroke, indicates a lower probability of atherosclerotic genesis of acute vascular cerebrovascular disorder. English version of the article is available at URL:https://panor.ru/articles/changes-in-laboratory-parameters-of-lipid-metabolism-in-hiv-infected-patients-with-cerebral-stroke/80579.html
Modern approaches to the diagnosis and treatment of coccygodynia
Authors:   FBHI «Privolzhsky District Medical Center», Nizhny Novgorod, Yarikov Anton Viktorovich , Shpagin Maksim Vladimirovich ,   SBHI NR «City Clinical Hospital No. 39», Nizhny Novgorod, Perlmutter Olga Aleksandrovna ,   Federal State Budgetary Educational Institution of Higher Education «Privolzhsky Research Medical University», Fraerman Alexander Petrovich ,   Federal State Budgetary Educational Institution of Higher Education «Volga Research Medical University», Sosnin Andrey Gennadievich ,   Privolzhsky District Medical Center, Simonov Alexander Evgenievich ,   City Clinical Hospital No. 39, Kotelnikov Alexander Olegovich ,   Federal State Budgetary Institution Russian Research Center «Restorative Traumatology and Orthopedics named after Academician G. A. Ilizarov, Garipov Ilgiz Ildarovich ,   Federal State Budgetary Institution Russian Scientific Center «Restorative Traumatology and Orthopedics named after academician G. A. Ilizarov, Mukhin Alexey Stanislavovich ,   Hospital Surgery named after B. A. Korolev FSBI «Privolzhsky Research Medical University», Tarasov Igor Andreevich ,   FBUZ «Federal Siberian Scientific and Clinical Center» of the Federal Medical and Biological Agency, Pavlinov Sergey Evgenyevich ,   MIRT Medical Center, Kostroma, Smirnov Igor Igorevich ,   City Clinical Hospital No. 39
Published: March 2022

Currently, there are no clear clinical guidelines for the diagnosis and treatment of coccygodynia. There are still debatable issues related to the choice of the most optimal diagnostic method, evaluation of the effectiveness of blockades, establishment of indications for surgical treatment and the determination of the most appropriate method of surgery. The features of the anatomical structure of the coccyx are considered in the scientific paper. The clinical picture and neurological symptoms of coccygodynia are described in detail. Modern instrumental methods of diagnosis of this disease (spondylography, MSCT, MRI) are presented. Modern scientific works on evaluating the effectiveness of conservative and surgical treatment have been studied. The methods of surgical treatment of patients with coccygodynia are analyzed. Indications for surgical treatment and the results of surgeries in patients with coccygodynia are considered. In addition, the authors presented their classification of coccygodynia.
Cost accounting for the provision of hemodialysis services in medical institutions
Authors:   Federal State Budgetary Educational Institution of Higher Education “Bryansk State University named after I.G. Petrovsky”, Dedova Olga Vasilyevna , Kovaleva Natalia Nikolaevna ,   Federal State Budgetary Educational Institution of Higher Education “Bryansk State University named after I.G. Petrovsky”, Ermakova Lyudmila Vladimirovna ,   Federal State Budgetary Educational Institution of Higher Education “Bryansk State University named after I.G. Petrovsky”, Dvoretskaya Yulia Alexandrovna ,   Federal State Budgetary Educational Institution of Higher Education “Bryansk State University named after I.G. Petrovsky”
Published: March 2022

Medical institutions of the state and non-state sector currently provide a wide range of health services, among which a special place is occupied by hemodialysis procedures. This process in the usual sense is the purification of the blood of a sick patient with the help of special devices and devices under the supervision of medical personnel. The development of such services for citizens with a high degree of kidney damage allows the population to live and work comfortably enough for a longer period of time than without the dialysis process. The cost structure for hemodialysis departments is quite typical, the features are related to the structure of the drugs and chemicals used, as well as some types of work and services purchased from third parties. For public sector organizations, the costs incurred are mainly reflected as expenses of the current fiscal year.
Features of accounting of bank guarantees in the process of public procurement by a budget institution
Authors:   Plekhanov Russian University of Economics, Titova E.I. , Zatsarinnaya E.I. ,   Plekhanov Russian University of Economics
Published: March 2022

The article discusses the features of accounting for bank guarantees in the process of public procurement by a budget institution. The problems of this article are relevant, since acting as a customer in the process of public procurement, a budget institution receives bank guarantees as collateral for obligations from the supplier (contractor, contractor). They are an effective tool to reduce the risk of non-fulfillment of customer requirements. But unlike commercial organizations, the accounting of bank guarantees by a budget institution has its own peculiarities.
Sources of funding architectural and construction complex of the Kyrgyz Republic: analysis and problems
Authors: Dzholdosheva T. .. , Tuleberdiev A. ..
Published: March 2022

The article outlines the features of the architectural and construction complex and the sources of financing for the activities of construction companies. The analysis of the dynamics and structure of the main sources of financing of the construction industry of the Kyrgyz Republic is carried out. The positive and negative aspects of the use of various sources of financing are considered and the problems of their limitations in the Kyrgyz Republic are identified.
Analysis of the budget of Bayan-Ulgiy Aymag of the Republic of Mongolia for 2020
Authors: Kravchenko P. ..
Published: March 2022

The article analyzes the budget of the Bayan-Ulgiy aimag of the Republic of Mongolia. The structure of revenues and expenditures of the local budget is considered.
Classification of factors influencing the dynamics of household socio-economic inequality
Authors: Dorofeev M. ..
Published: March 2022

In 2020, the problems of socio-economic inequality began to noticeably gain popularity in the media and received another round of discussion in scientific literature. New socio-economic challenges again raise a number of old questions that have to be answered by regulators in the new reality. Among such issues are the question of understanding the true causes of changing socio-economic inequalities in the world. The article explores the issue of classification of possible causes and factors influencing the dynamics of socio-economic inequality. It is proposed to classify all causes and factors into two groups according to the criterion of financial mechanism setup: exogenous (financial mechanism stays unchanged) and endogenous (financial mechanism is reconfigured by regulator for some reason). Then we discuss the paradox of modern financial regulation and the prospect of changing the settings of the financial mechanism, and make some conclusions for regulators.
Formation of information support for assessment of logistics potential of the region
Authors: Strebkova L. ..
Published: March 2022

To develop, refine, evaluate and monitor the implementation of strategic and operational measures, improve the efficiency and sustainability of the region, information is needed to identify existing opportunities and problems. The assessment of the logistics potential of the region contributes to increasing the level of information support for managerial decision-making on various aspects of the region's activities and reducing the associated risks, not only logistics, but also economic, financial, and innovative. The article substantiates the feasibility of analyzing the regional logistics system, presents the process of forming information support for assessing the logistics potential of the region. It was also noted that it is necessary to conduct such a research taking into account the territorial specifics in order to further strategic planning of the region's development and increase its competitiveness. To develop, refine, evaluate and monitor the implementation of strategic and operational measures, to ensure sustainable balanced development of the region, information is needed to identify the existing opportunities and problems. Such information can be created and structured accordingly when forming a regional logistics system. The assessment of the logistics potential of the region contributes to increasing the level of information support for managerial decision-making on various aspects of the region's activities and reducing the associated risks, not only logistical, but also economic (financial). The article substantiates the feasibility of analyzing the regional logistics system, presents the process of forming information support for assessing the logistics potential of the region. The necessity of conducting such a study taking into account the territorial specifics in order to further strategic planning of the socio-economic development of the region and increase its competitiveness was also noted.
Miscarriage: Marking Time
Authors: Занько С.Н. , Жабченко И.А. , Журавлев А.Ю.
Published: March 2022

Преждевременные роды (ПР) были, есть и будут самой важной проблемой современного акушерства, ибо подавляющее большинство перинатальных потерь определяется недоношенностью новорожденных.По точному определению известного в мире специалиста G.C. Di Renzo на Всемирном конгрессе COGI: преждевременные роды (ПР): причины – неясные, диагностика – затруднена, методы – дискутабельны, результаты – непредсказуемы, цена – огромная.Нами проведено пилотное исследование совместного использования вагинального прогестерона и акушерского пессария. Полученные результаты вселяют оптимизм и позволяют рекомендовать подходы, которые описаны выше, к широкому медицинскому использованию. Предлагаемая медицинская технология утверждена Министерством здравоохранения Республики Беларусь в качестве инструкции по применению.

Preterm labor (PL) was, is and will be the most important problem of modern obstetrics, because the overwhelming majority of perinatal losses are determined by the prematurity of newborns.According to the exact definition of the world-famous specialist G. C. Di Renzo at COGI World Congress: preterm labor (PL): the reasons are unclear, the diagnosis is difficult, the methods are debatable, the results are unpredictable, the price is huge.We have conducted a pilot study of the combined use of vaginal progesterone and obstetrical pessary. The obtained results are encouraging and allow us to recommend the described above approaches for wide medical use. The proposed medical technology is approved by the Ministry of Health of the Republic of Belarus as an instruction for use.
Contemporary Approach towards Etiology, Pathogenesis and Classification of Ovarian Hyperstimulation Syndrome (Review)
Authors: Жуковская С.В.мл , Жуковская С.В.
Published: March 2022

Синдром гиперстимуляции яичников (СГЯ) – одно из наиболее опасных ятрогенных осложнений контролируемой овариальной стимуляции в программах вспомогательных репродуктивных технологий (ВРТ). Частота возникновения СГЯ составляет до 33% от всех циклов ВРТ. СГЯ – сложный многозвеньевой процесс, начинающийся с супрафизологической концентрации гормонов как экзогенной, так и эндогенной природы, что приводит к синтезу и высвобождению биологически активных веществ и провоспалительных медиаторов (СЭФР, растворимый сосудистый эндотелиальный кадгерин, ИЛ-1, ИЛ-2, ИЛ-6, ИЛ-8, трансформирующий ростовой фактор-бета и др.), а также к чрезмерной активации ренин-ангиотензин-альдостероновой системы. Системная эндотелиальная дисфункция становится причиной повышения проницаемости капилляров, что является ключевым звеном в возникновении характерной клинической картины: гиповолемии, гемоконцентрации, абдоминального компартмент-синдрома, системного воспалительного ответа и развития полиорганной недостаточности, манифестирующей с острого повреждения почек и нередко приводящей к тромбоэмболическим осложнениям и острому респираторному дистресс-синдрому.

Ovarian hyperstimulation syndrome (OHSS) is one of the most dangerous iatrogenic complications of controlled ovarian stimulation in assisted reproductive technologies (ART). The prevalence of this pathology is considerably high – it constitutes up to 33% of all ART procedures. OHSS is a complex multistage process caused by supraphysiological concentrations of exogenous and endogenous hormones, which leads to increased production and release of biologically active substances and proinflammatory mediators (VEGF, soluble VE-cadherin, IL-1, IL-2, IL-6, IL-8, transforming growth factor-beta, etc.), and to hyperactivation of renin-angiotensin-aldosterone system. Systemic endothelial dysfunction leads to excessive capillary permeability, which becomes a key point in OHSS pathogenesis and clinical presentation including hypovolemia, hemoconcentration, abdominal compartment syndrome, systemic inflammatory response and multiple organ dysfunction that commonly presents with acute kidney injury and leads to thromboembolism and acute respiratory distress syndrome.
Luis Herrera Mesa. Ecología, cambio climático y sexta extinción. Editorial: Mc Graw-Hill Interamericana S.L. 2021.
Authors: Alba-Tercedor Javier
Published: March 2022

Hace ya varias décadas que el impacto mediático de la aparición de un gran agujero en la capa ozono, a nivel de la Antártida, fue un punto de inflexión por el cual se tuvo conciencia de lo que la actividad humana estaba produciendo a nivel planetario, y se tomaron medidas prohibiendo los clorofluorocarbonos (CFC) responsables de esa degradación. Lo que ha tenido un efecto muy positivo en la capa protectora de ozono que rodea la tierra.......
The Moderator Effect of the Perceived Quality of Meal Service on the Relationship between Mobbing, Job Stress and Job Performance
Authors: KAMBUR Emine
Published: March 2022

With the increase of mobbing and stress in business life, employees such as depression, loss of motivation and anxiety may occur. These negative feelings can affect the job performance of employees. In addition, the nutrition of employees can regulate their stress and performance. In this study the mediating, moderating and moderated-mediation effects of the variables of mobbing, job stress, job performance and perceived quality of meal service have been examined. The study has been carried out with 283 blue-collar employees of a private company. The research has been conducted with the primary research method, the questionnaire. As a result of the study, it has been determined that the effect of mobbing on job performance is significant that is, job stress mediates the relationship between mobbing and job performance. It has been found that the effects of job stress, perceived quality of meal service and interactional term on job performance are significant. In addition, it has been revealed that the perceived quality of meal service has a moderating effect. Finally, the indirect effect of mobbing on job performance through job stress has been found to be higher when the perceived quality of meal service is low and moderate. That is, the moderated-mediation index value is significant.