bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of physician burnout with perceived EHR work stress and potentially actionable factors
Authors: Tai-Seale Ming , Baxter Sally , Millen Marlene , Cheung Michael , Zisook Sidney , Çelebi Julie , Polston Gregory , Sun Bryan , Gross Erin , Helsten Teresa , Rosen Rebecca , Clay Brian , Sinsky Christine , Ziedonis Douglas M , Longhurst Christopher A , Savides Thomas J
Published: July 2023

Objective

Physicians of all specialties experienced unprecedented stressors during the COVID-19 pandemic, exacerbating preexisting burnout. We examine burnout’s association with perceived and actionable electronic health record (EHR) workload factors and personal, professional, and organizational characteristics with the goal of identifying levers that can be targeted to address burnout.

Materials and Methods

Survey of physicians of all specialties in an academic health center, using a standard measure of burnout, self-reported EHR work stress, and EHR-based work assessed by the number of messages regarding prescription reauthorization and use of a staff pool to triage messages. Descriptive and multivariable regression analyses examined the relationship among burnout, perceived EHR work stress, and actionable EHR work factors.

Results

Of 1038 eligible physicians, 627 responded (60% response rate), 49.8% reported burnout symptoms. Logistic regression analysis suggests that higher odds of burnout are associated with physicians feeling higher level of EHR stress (odds ratio [OR], 1.15; 95% confidence interval [CI], 1.07–1.25), having more prescription reauthorization messages (OR, 1.23; 95% CI, 1.04–1.47), not feeling valued (OR, 3.38; 95% CI, 1.69–7.22) or aligned in values with clinic leaders (OR, 2.81; 95% CI, 1.87–4.27), in medical practice for ≤15 years (OR, 2.57; 95% CI, 1.63–4.12), and sleeping for <6 h/night (OR, 1.73; 95% CI, 1.12–2.67).

Discussion

Perceived EHR stress and prescription reauthorization messages are significantly associated with burnout, as are non-EHR factors such as not feeling valued or aligned in values with clinic leaders. Younger physicians need more support.

Conclusion

A multipronged approach targeting actionable levers and supporting young physicians is needed to implement sustainable improvements in physician well-being.
Differences of semen microbiota among breeding boars with different reproductive ages
Authors: Li Desheng , Xu Yunhe , Wang Mi , Fang Shan , Li Shi Han , Cui Yan
Published: July 2023

In this study, we investigated 18 healthy and fertile Duroc boars, dividing them into two groups based on their reproductive age: 9 boars aged 18 mo and 9 boars aged 36 mo. Prior to semen sampling, all boars were raised together under identical management conditions for a period of 3 mo. Our findings revealed that older boars exhibited lower sperm motility and a higher proportion of abnormal sperm morphology compared to younger boars. Furthermore, older boars demonstrated lower anti-oxidant capacity in their semen, as indicated by elevated levels of malondialdehyde and decreased levels of superoxide dismutase and glutathione peroxidase. Microbiota analysis utilizing the 16S rRNA technique showed that the semen microbiota of older boars had reduced alpha-diversity and beta-diversity in comparison to younger boars. We identified the Streptococcus genus and Streptococcus gallolyticus subsp macedonicus species served as biomarkers for semen from younger breeding boars, while the Bacteroides pyogenes species as a biomarker for semen from older breeding boars. Additionally, the semen from older boars exhibited a higher abundance of Aerococcus, Gallicola, Ulvibacter, and Proteiniphilum compared to younger boars. Spearman correlation analysis showed that these four bacteria were negatively correlated with semen quality. The abundance of Gallicola and Proteiniphilum were negatively correlated with semen anti-oxidant capacity. Additionally, the reduction of semen anti-oxidant capacity was correlated to the decrease of semen quality. Based on these findings, we concluded that the semen of older boars contains a higher abundance of harmful bacteria, which contributes to the observed reduction in semen anti-oxidant capacity and overall semen quality in this group.
Why Prosecuting Aggression in Ukraine as a Crime Against Humanity Might Make Sense
Authors: Mégret Frédéric
Published: July 2023

The idea that aggression can and maybe should be prosecuted in some instances as a crime against humanity is a marginal one that has nonetheless been floated for a while. This article revisits the idea in the context of efforts to prosecute the leaders of the Russian aggression in Ukraine. It argues that the case that aggression is a crime against humanity has been framed along excessively reductionist lines focusing on ‘other inhumane acts’ as a predicate offence. Instead, the article suggests that there can be a deep overlap between the notion of an armed attack against a state as defining aggression, and the notion of a ‘widespread or systematic attack against a civilian population’ as the chapeau of crimes against humanity. Working at this intersection, it is suggested, makes sense of the special place of aggression as an offence generative of many others, as well as the particular sovereign deliberateness involved in launching an attack. The article explores some of the concerns that such a prosecution might trigger, including that it misses the opportunity to prosecute aggression as such, is in bad faith, or does not cover significant portions of what is rightly considered wrong about aggression. The article concludes in favor of an imaginative take on the substantive law resources that are there rather than the search for new jurisdictional solutions.
LESION MIMIC MUTANT 1 confers basal resistance to Sclerotinia sclerotiorum in rapeseed via a salicylic acid-dependent pathway
Authors: Yu Mengna , Fan Yonghai , Li Xiaodong , Chen Xingyu , Yu Shijie , Wei Siyu , Li Shengting , Chang Wei , Qu Cunmin , Li Jiana , Lu Kun
Published: July 2023

Rapeseed (Brassica napus) is a major edible oilseed crop consumed worldwide. However, its yield is seriously affected by infection from the broad-spectrum non-obligate pathogen Sclerotinia sclerotiorum due to a lack of highly resistant germplasm. Here, we identified a Sclerotinia-resistant and light-dependent lesion mimic mutant from an ethyl methanesulfonate-mutagenized population of the rapeseed inbred Zhongshuang 11 (ZS11) named lesion mimic mutant 1 (lmm1). The phenotype of lmm1 is controlled by a single recessive gene, named LESION MIMIC MUTANT 1 (LMM1), which mapped onto chromosome C04 by bulked segregant analysis within a 2.71-Mb interval. Histochemical analysis indicated that H2O2 strongly accumulated and cell death occurred around the lesion mimic spots. Among 877 differentially expressed genes (DEGs) between ZS11 and lmm1 leaves, 188 DEGs were enriched in the defense response, including 95 DEGs involved in systemic acquired resistance, which is consistent with the higher salicylic acid levels in lmm1. Combining bulked segregant analysis and transcriptome analysis, we identified a significantly up-regulated gene, BnaC4.PR2, which encodes β-1,3-glucanase, as the candidate gene for LMM1. Overexpression of BnaC4.PR2 may induce a reactive oxygen species burst to trigger partial cell death and systemic acquired resistance. Our study provides a new genetic resource for S. sclerotiorum resistance as well as new insights into disease resistance breeding in B. napus.
Magnetic frame-dragging correction to the electromagnetic solution of a compact neutron star
Authors: Torres R , Grismayer T , Cruz F , Silva L O
Published: July 2023

Neutron stars are usually modelled as spherical, rotating perfect conductors with a predominant intrinsic dipolar magnetic field anchored to their stellar crust. Due to their compactness, General Relativity corrections must be accounted for in Maxwell’s equations, leading to modified interior and exterior electromagnetic solutions. We present analytical solutions for slowly rotating magnetized neutron stars, taking into account the magnetic frame-dragging correction. For typical compactness values, i.e. Rs ∼ 0.5 [R*], we show that the new terms lead to a per cent order correction in the magnetic field orientation and strength compared to the case, with no magnetic frame-dragging correction. Also, we obtain a self-consistent redistribution of the surface azimuthal current. We verify the validity of the derived solution through two-dimensional particle-in-cell simulations of an isolated neutron star. Defining the azimuthal electric and magnetic field amplitudes during the transient phase as observables, we prove that the magnetic frame-dragging correction reduces the transient wave amplitude, as expected from the analytical solution. We show that simulations are more accurate and stable, when we include all first-order terms. The increased accuracy at lower spatiotemporal resolutions translates into a reduction in simulation runtimes.
Discovery of dipolar chromospheres in two white dwarfs
Authors: Farihi J , Hermes J J , Littlefair S P , Howarth I D , Walters N , Parsons S G
Published: July 2023

This paper reports the ULTRACAM discovery of dipolar surface spots in two cool magnetic white dwarfs with Balmer emission lines, while a third system exhibits a single spot, similar to the prototype GD 356. The light curves are modelled with simple, circular, isothermal dark spots, yielding relatively large regions with minimum angular radii of 20°. For those stars with two light-curve minima, the dual spots are likely observed at high inclination (or colatitude); however, identical and antipodal spots cannot simultaneously reproduce both the distinct minima depths and the phases of the light-curve maxima. The amplitudes of the multiband photometric variability reported here are all several times larger than that observed in the prototype GD 356; nevertheless, all DAHe stars with available data appear to have light-curve amplitudes that increase towards the blue in correlated ratios. This behaviour is consistent with cool spots that produce higher contrasts at shorter wavelengths, with remarkably similar spectral properties given the diversity of magnetic field strengths and rotation rates. These findings support the interpretation that some magnetic white dwarfs generate intrinsic chromospheres as they cool, and that no external source is responsible for the observed temperature inversion. Spectroscopic time-series data for DAHe stars is paramount for further characterization, where it is important to obtain well-sampled data, and consider wavelength shifts, equivalent widths, and spectropolarimetry.
Density and velocity correlations in isothermal supersonic turbulence
Authors: Rabatin Branislav , Collins David C
Published: July 2023

In star-forming clouds, high velocity flow gives rise to large fluctuations of density. In this work, we explore the correlation between velocity magnitude (speed) and density. We develop an analytic formula for the joint probability distribution function (PDF) of density and speed, and discuss its properties. In order to develop an accurate model for the joint PDF, we first develop improved models of the marginalized distributions of density and speed. We confront our results with a suite of 12 supersonic isothermal simulations with resolution of $1024^3$ cells in which the turbulence is driven by 3 different forcing modes (solenoidal, mixed, and compressive) and 4 rms Mach numbers (1, 2, 4, 8). We show, that for transsonic turbulence, density and speed are correlated to a considerable degree and the simple assumption of independence fails to accurately describe their statistics. In the supersonic regime, the correlations tend to weaken with growing Mach number. Our new model of the joint and marginalized PDFs are a factor of 3 better than uncorrelated, and provides insight into this important process.
Heterogeneity in subjective cognitive decline in the Sino Longitudinal Study on Cognitive Decline(SILCODE): Empirically derived subtypes, structural and functional verification
Authors: Fu Zhenrong , Zhao Mingyan , Li Yuxia , He Yirong , Wang Xuetong , Zhou Zongkui , Han Ying , Li Shuyu
Published: July 2023

Aims

We evaluated whether Subjective Cognitive Decline (SCD) subtypes could be empirically derived within the Sino Longitudinal Study on Cognitive Decline (SILCODE) SCD cohort and examined associated neuroimaging markers, biomarkers, and clinical outcomes.

Methods

A cluster analysis was performed on eight neuropsychological test scores from 124 SCD SILCODE participants and 57 normal control (NC) subjects. Structural and functional neuroimaging indices were used to evaluate the SCD subgroups.

Results

Four subtypes emerged: (1) dysexecutive/mixed SCD (n = 23), (2) neuropsychiatric SCD (n = 24), (3) amnestic SCD (n = 22), and (4) cluster‐derived normal (n = 55) who exhibited normal performance in neuropsychological tests. Compared with the NC group, each subgroup showed distinct patterns in gray matter (GM) volume and the amplitude of low‐frequency fluctuations (ALFF). Lower fractional anisotropy (FA) values were only found in the neuropsychiatric SCD group relative to NC.

Conclusion

The identification of empirically derived SCD subtypes demonstrates the presence of heterogeneity in SCD neuropsychological profiles. The cluster‐derived normal group may represent the majority of SCD individuals who do not show progressive cognitive decline; the dysexecutive/mixed SCD and amnestic SCD might represent high‐risk groups with progressing cognitive decline; and finally, the neuropsychiatric SCD may represent a new topic in SCD research.
Adult hemiconvulsive hemiatrophy syndrome: a novel clinicoradiologic disorder in adults
Authors: Kam Ian , Phatouros Constantine , Prentice David , Kho Lay K. , Parizel Paul
Published: July 2023

The association of focal motor seizures with cerebral hemiatrophy is a recognised rare paediatric syndrome known as ‘hemiconvulsion, hemiatrophy and epilepsy’ (HHE). To date, HHE has not been reported in adults. We present four adult patients with striking similarities to HHE, following alcohol withdrawal in chronic alcoholics. We document the imaging findings in the acute and subacute phases, discuss the underlying mechanisms and present a hypothesis regarding the pathophysiology.
Atopic dermatitis and risk of 14 site‐specific cancers: A Mendelian randomization study
Authors: Liu Qiang , Chen Li , Wang Yipeng , Wang Xiangyu , Lewis Sarah J. , Wang Jing
Published: July 2023

Background

Atopic dermatitis (AD) accounts for a large proportion of the burden of skin disease, with a prevalence of around 10% among adults worldwide. In addition, systematic reviews and meta‐analyses have found that AD is associated with cancer risk at several sites; if found to be causal this could highlight potential treatment targets to reduce cancer risk.

Objectives

To assess the potential causative link between AD and 14 site‐specific cancers in a two‐sample randomization study.

Methods

From the largest genome‐wide association study (GWAS) of AD (10,788 cases and 30,047 non‐cases), genetic variants highly associated (p < 5 × 10−8) with AD in the European population were selected as instrumental variables (IVs). Data from large cancer consortia, as well as the UK Biobank study (n = 442,239) and the FinnGen study (n = 218,792), were employed to assess genetic associations with 14 site‐specific cancers and overall cancer. A set of complementary approaches and sensitivity analyses were carried out to examine the robustness of our results. In addition, associations for the same cancer site from different data sources were combined using meta‐analyses.

Results

We discovered no strong causal evidence of AD on the risk of overall cancer, with effect estimates close to zero. After the Benjamini–Hochberg correction, the inverse‐variance weighted method indicated no association between AD and overall cancer risk in both the UK Biobank (OR, 1.00; 95% CI, 0.94–1.06; FDR, 0.98) and FinnGen studies (OR, 0.96; 95% CI, 0.92–1.02; FDR, 0.68). No strong evidence of an association was found between genetically predicted AD and the risk of any site‐specific cancers.

Conclusions

Our MR investigation does not support a causal effect of AD on cancer risk. This finding has important implications for the prevention and management of both AD and cancer, as it reduces the concern of potential adverse effects of AD on cancer outcomes.
Plasma chemistry reference intervals for adult multi‐drug‐resistance gene deficient Collies
Authors: Massat M. Joan , Myles Matthew , DeJong Keith , Ballard Chelsea , Drag Marlene , Malinski Thomas J.
Published: July 2023

Background

Differences in the reference intervals between dog breeds have been recognized for many years. Due to the importance of multi‐drug‐resistance 1‐deficient (MDR1) Collies in veterinary medicine, it is important to determine whether breed‐specific reference intervals are needed for this group.

Objectives

The goal of this study was to establish plasma chemistry reference intervals for adult MDR1‐deficient Collies.

Methods

Plasma samples collected from 110 healthy male and female adult MDR1‐deficient Collies were analyzed for 21 analytes on a Beckman AU480 clinical chemistry analyzer. Reference intervals were established using a nonparametric statistical method.

Results

Reference intervals were established for 21 biochemical measurands in healthy adult MDR1‐deficient Collies.

Conclusion

Plasma chemistry reference intervals for MDR1‐deficient Collies were clinically similar to intervals earlier created for Beagles. Intervals for male and female MDR1‐deficient Collies were very similar to each other.
Filtration Methods for Microplastic Removal in Wastewater Streams — A Review
Authors: Salahuddin U. , Sun J. , Zhu C. , Gao P.
Published: July 2023

Microplastics are commonly recognized as environmental and biotic contaminants. The prevalent presence of microplastics in aquatic settings raises concerns about plastic pollution. Therefore, it is critical to develop methods that can eliminate these microplastics with low cost and high effectiveness. This review concisely provides an overview of various methods and technologies for removing microplastics from wastewater and marine environments. Dynamic membranes and membrane bioreactors are effective in removing microplastics from wastewater. Chemical methods such as coagulation and sedimentation, electrocoagulation, and sol-gel reactions can also be used for microplastic removal. Biological methods such as the use of microorganisms and fungi are also effective for microplastic degradation. Advanced filtration technologies like a combination of membrane bioreactor and activated sludge method show high microplastic removal efficiency.
Vector Quantized Convolutional Autoencoder for Low-Dose CT Image Reconstruction with Perceptual and Bias Reducing Loss
Authors: Ramanathan Shalini , Ramasundaram Mohan
Published: July 2023

In medical imaging, Computed Tomography (CT) is one of the most often utilized imaging modalities for diagnosing different disorders. Deep learning has become significant in the field of medical imaging, specifically investigated for low-dose CT. In recently available CT Scanners, Low Dose CT (LDCT) reconstruction is presented with a post-processing approach, which uses deep learning-based methods to reduce the noise level. Applying low radiation dosage can decrease damage to patients but the projected image is corrupted with noise due to lower intensity and fewer angle measurements, resulting in excessive noise in the reconstructed CT image. Thus, the presence of noise and artifacts in LDCT images limits their potential use. Here, a vector quantized convolutional encoder network is proposed for the image reconstruction task. The network is trained using the LoDoPaB-CT Dataset and tested on chest CT images. The qualitative and quantitative results produced better quality results when compared with the recent state-of-art deep learning-based methods. The quality of the results is optimized with perceptual and Bias-Reducing loss functions.
Wage Effects of Couples’ Divisions of Labour across the UK Wage Distribution
Authors: Blom Niels , Cooke Lynn Prince
Published: July 2023

Specialisation and gender theories offer competing hypotheses of whether men’s and women’s wages rise or fall based on the couple’s division of household unpaid and paid labour, and how effects differ across the wage distribution. We test division effects by analysing British panel data using unconditional quantile regression with individual fixed effects, controlling for own hours in housework and employment. We find only high-wage men’s wages were significantly greater when their partners specialised in routine housework, and when they were the sole breadwinner. Conversely, low- and high-wage partnered women incurred significant wage penalties as their share of housework exceeded their partners’. Wages for low-wage men and median- and high-wage women also decreased as their share of household employment increased. We conclude only elite partnered men benefit from specialisation. Everyone else is either better off or no worse off with equitable household divisions of paid and unpaid work.
Comparison of ultrasound-guided transversalis fascia plane block and anterior quadratus lumborum block in patients undergoing caesarean delivery: a randomized study
Authors: Bilgin Sezgin , Aygun Hakan , Genc Caner , Dost Burhan , Tulgar Serkan , Kaya Cengiz , Sertoz Nezih , Koksal Ersin
Published: July 2023

Background

Cesarean section is becoming increasingly common. Well-managed postoperative analgesia improves patient comfort while encouraging early ambulation and breastfeeding. The analgesic efficacy of transversalis facial plane block (TFPB) vs. anterior quadratus lumborum block (QLB) was compared in this study.

Methods

We analyzed the data of 49 pregnant women (gestation, ≥ 37weeks; age, 18–45years) scheduled for elective cesarean delivery (CD) under general anesthesia. They were randomly divided into TFPB and anterior QLB groups. All blocks were administered bilaterally with 25mL of 0.25% bupivacaine under ultrasound guidance prior to extubation. Postoperative morphine consumption and numerical rating scale (NRS) pain scores (static and dynamic [during coughing]) were recorded at 1, 3, 6, 9, 12, 18, and 24h.

Results

There was no difference in postoperative morphine consumption between the groups at the third, sixth, and ninth hours, but the anterior QLB group consumed less morphine at the 12th, 18th, and 24th hours. Except for the first hour, resting and dynamic NRS scores were comparable between the groups. The first-hour resting and dynamic NRS scores were lower in the TFPB group (resting NRS, anterior QLB group, median [interquartile range], 2 [2–3] vs. TFPB group, 2 [0–2],p = 0.046; dynamic NRS, anterior QLB group, median [interquartile range], 3 [2–4] vs. TFPB group 2 [0–3],p = 0.001).

Conclusions

In patients undergoing CD, anterior QLB decreased morphine consumption in the late period (9–24h) compared to TFPB, while pain scores were similar between both groups. The reduction in morphine consumption was statistically significant, but not clinically significant.
Prevalence of dyslipidemia and its associated factors among university academic staff and students in Bangladesh
Authors: Ali Nurshad , Kathak Rahanuma Raihanu , Fariha Khandaker Atkia , Taher Abu , Islam Farjana
Published: July 2023

Background

Dyslipidemia is one of the important contributors to cardiovascular disease and type 2 diabetes. There is little or no information on dyslipidemia among academic staff and students in Bangladesh. Therefore, this study aimed to investigate the prevalence and factors related to dyslipidemia among university academic staff and students in Bangladesh.

Methods

A total of 533 participants (302 academic staff and 231 students) were enrolled in this cross-sectional study. A simple random sampling technique was used to enrol the participants. Fasting blood samples were obtained from the participants, and serum levels of triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured using the standard methods. Dyslipidemia was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP-III) model guideline. Multivariable logistic regression was conducted to identify the factors related to lipid marker abnormalities.

Results

Overall, the prevalence of dyslipidemia was 81.5%, of which 85% was in staff and 76.5% in students. A significant difference was found in the prevalence of dyslipidemia between males and females only in the student group (p < 0.01). Among staff, hypertriglyceridemia prevalence was 49.7%, hypercholesterolemia 23%, high LDL-C 24.7% and low HDL-C 77.3%. On the other hand, hypertriglyceridemia prevalence was 39%, hypercholesterolemia 25.6%, high LDL-C 26.5% and low HDL-C 69.3% among students. The most common lipid abnormality was low HDL-C in both groups. The prevalence of mixed dyslipidemia was 14.2% and 14.1% in staff and students, respectively. According to the regression analysis, increased age, obesity, diabetes, and inadequate physical activity were significantly associated with dyslipidemia.

Conclusions

Dyslipidemia was prevalent among the majority of the study participants. Increased age, obesity, diabetes, and inadequate physical activity were significantly associated with dyslipidemia. The study’s results highlight the importance of implementing interventions to address the associated risk factors of dyslipidemia among academic staff and students in Bangladesh.
Identifying self-presentation components among nursing students with unsafe clinical practice: a qualitative study
Authors: Ghasempour Mostafa , Ghahramanian Akram , Zamanzadeh Vahid , Valizadeh Leila , Killam Laura A. , Asghari-Jafarabadi Mohammad , Purabdollah Majid
Published: July 2023

Background

Maintaining patient safety is a practical standard that is a priority in nursing education. One of the main roles of clinical instructors is to evaluate students and identify if students exhibit unsafe clinical practice early to support their remediation. This study was conducted to identify self-presentation components among nursing students with unsafe clinical practice.

Methods

This qualitative study was conducted with 18 faculty members, nursing students, and supervisors of medical centers. Data collection was done through purposive sampling and semi-structured interviews. Data analysis was done using conventional qualitative content analysis using MAXQDA10 software.

Results

One main category labelled self-presentation emerged from the data along with three subcategories of defensive/protective behaviors, assertive behaviors, and aggressive behaviors.

Conclusion

In various clinical situations, students use defensive, assertive, and aggressive tactics to maintain their professional identity and present a positive image of themselves when they make a mistake or predict that they will be evaluated on their performance. Therefore, it seems that the first vital step to preventing unsafe behaviors and reporting medical errors is to create appropriate structures for identification, learning, guidance, and evaluation based on progress and fostering a growth mindset among students and clinical educators.
Identification and analysis of lipid metabolism-related genes in allergic rhinitis
Authors: Tao Qilei , Zhu Yajing , Wang Tianyu , Deng Yue , Liu Huanhai , Wu Jian
Published: July 2023

Background

Studies have shown that the lipid metabolism mediator leukotriene and prostaglandins are associated with the pathogenesis of allergic rhinitis (AR). The aim of this study was to identify key lipid metabolism-related genes (LMRGs) related to the diagnosis and treatment of AR.

Materials and methods

AR-related expression datasets (GSE75011, GSE46171) were downloaded through the Gene Expression Omnibus (GEO) database. First, weighted gene co-expression network analysis (WGCNA) was used to get AR-related genes (ARRGs). Next, between control and AR groups in GSE75011, differentially expressed genes (DEGs) were screened, and DEGs were intersected with LMRGs to obtain lipid metabolism-related differentially expressed genes (LMR DEGs). Protein-protein interaction (PPI) networks were constructed for these LMR DEGs. Hub genes were then identified through stress, radiality, closeness and edge percolated component (EPC) analysis and intersected with the ARRGs to obtain candidate genes. Biomarkers with diagnostic value were screened via receiver operating characteristic (ROC) curves. Differential immune cells screened between control and AR groups were then assessed for correlation with the diagnostic genes, and clinical correlation analysis and enrichment analysis were performed. Finally, real-time fluorescence quantitative polymerase chain reaction (RT-qPCR) was made on blood samples from control and AR patients to validate these identified diagnostic genes.

Results

73 LMR DEGs were obtained, which were involved in biological processes such as metabolism of lipids and lipid biosynthetic processes. 66 ARRGs and 22 hub genes were intersected to obtain four candidate genes. Three diagnostic genes (LPCAT1, SGPP1, SMARCD3) with diagnostic value were screened according to the AUC > 0.7, with markedly variant between control and AR groups. In addition, two immune cells, regulatory T cells (Treg) and T follicular helper cells (TFH), were marked variations between control and AR groups, and SMARCD3 was significantly associated with TFH. Moreover, SMARCD3 was relevant to immune-related pathways, and correlated significantly with clinical characteristics (age and sex). Finally, RT-qPCR results indicated that changes in the expression of LPCAT1 and SMARCD3 between control and AR groups were consistent with the GSE75011 and GSE46171.

Conclusion

LPCAT1, SGPP1 and SMARCD3 might be used as biomarkers for AR.
Viscoacoustic reverse time migration with stable and effective two-way attenuation compensation
Authors: Huang Chao , Jiao Zhuoer , Dong Liangguo , Liu Yuzhu
Published: July 2023

Intrinsic attenuation in seismic wave propagation leads to amplitude dissipation and phase dispersion in seismic data. The attenuation (∼1/ Q) effect is a common cause for inaccurate image locations and dimmed image energy in reverse time migration (RTM). Conventional viscoacoustic or viscoelastic RTM methods implement attenuation compensation by reversing the sign of the amplitude loss term and keeping the dispersion term unchanged for forward and backward wavefield extrapolation, which requires the decoupled viscoacoustic wave equation and gives rise to the numerical instability issue. To address these problems, we develop a stable and effective two-way attenuation-compensated viscoacoustic RTM method. Our method uses a new two-way normalized crosscorrelation imaging condition to compensate the attenuation effect. In the new imaging condition, only the attenuated forward wavefield of sources and the viscoacoustic Green’s functions of receivers are required, which eliminates the instability source arising from the operation of reversing the sign of the dissipation term in the viscoacoustic wave equation. Because no modifications are made to the viscoacoustic wave equation, the new imaging condition can be calculated without any additional computational cost and can be applied to decoupled and coupled viscoacoustic wave equation-based RTMs, which is more flexible than other attenuation compensation strategies. Two synthetic tests and one field data example are presented to demonstrate the stability and effectiveness of our method.
Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
Authors: Moreira Ana Rita Silva , Lim Juchan , Urbaniak Alicja , Banik Jewel , Bronson Katherine , Lagasse Alex , Hardy Linda , Haney Anessa , Allensworth Melody , Miles Tiffany K , Gies Allen , Byrum Stephanie D , Wilczynska Ania , Boehm Ulrich , Kharas Michael , Lengner Christopher , MacNicol Melanie C , Childs Gwen V , MacNicol Angus M , Odle Angela K
Published: July 2023

The anterior pituitary controls key biological processes, including growth, metabolism, reproduction, and stress responses through distinct cell types that each secrete specific hormones. The anterior pituitary cells show a remarkable level of cell type plasticity that mediates the shifts in hormone-producing cell populations that are required to meet organismal needs. The molecular mechanisms underlying pituitary cell plasticity are not well understood. Recent work has implicated the pituitary stem cell populations and specifically, the mRNA binding proteins of the Musashi family in control of pituitary cell type identity. In this study we have identified the target mRNAs that mediate Musashi function in the adult mouse pituitary and demonstrate the requirement for Musashi function in vivo. Using Musashi RNA immunoprecipitation, we identify a cohort of 1184 mRNAs that show specific Musashi binding. Identified Musashi targets include the Gnrhr mRNA, which encodes the gonadotropin-releasing hormone receptor (GnRHR), and the Fshb mRNA, encoding follicle-stimulating hormone (FSH). Reporter assays reveal that Musashi functions to exert repression of translation of the Fshb mRNA, in addition to the previously observed repression of the Gnrhr mRNA. Importantly, mice engineered to lack Musashi in gonadotropes demonstrate a failure to repress translation of the endogenous Gnrhr and Fshb mRNAs during the estrous cycle and display a significant heterogeneity in litter sizes. The range of identified target mRNAs suggests that, in addition to these key gonadotrope proteins, Musashi may exert broad regulatory control over the pituitary proteome in a cell type–specific manner.
Perceptions of an educational intervention for family caregivers of palliative care patients
Authors: Arias-Rojas Mauricio , Carreño-Moreno Sonia , Carmona-Montoya Xiomara
Published: July 2023

Background:

Nursing interventions aimed at family caregivers of palliative cancer patients require not only an objective evaluation, but also subjective consideration of their contributions, and a qualitative evaluation that provides an in-depth understanding of these interventions.

Aims:

This study aimed to explore the perceptions that family caregivers of palliative cancer patients had of the nursing intervention, PalliActive Caregivers, in reducing the uncertainty associated with illness and improving the caregiver's quality of life.

Methods:

A qualitative approach with content analysis was used. Telephone interviews were conducted with 23 caregivers who participated in the intervention.

Findings:

Five themes emerged from the content analysis: consolidating physical care, adopting a positive attitude, strengthening the support available to the caregiver, strengthening spirituality and strengthening relationships.

Conclusion:

The themes showed a positive impact of the intervention on aspects such as the caregiver's ability to cope, spirituality and social support of caregivers. The results also indicated the possibility of conducting this type of study to identify other assessment variables for future interventions.
Okul Temelli İntihar Önleme Programlarının İncelenmesi
Authors: CİVAN GÖKKAYA Sema
Published: July 2023

İntiharın gençler arasında yaygınlaşan bir halk sorunu olması gençlere yönelik intihar önleme programlarının incelenmesini önemli hale getirmektedir. Bu çalışmanın amacı okul temelli intihar önleme programlarının incelenmesidir. Çalışmada PRISMA rehberi kullanılmış ve EBSCHOhost, Web of Science ve Google Scholar veri tabanlarından tarama gerçekleştirilmiştir. Seçim ve dışlama kriterleri kapsamında yirmi çalışma araştırmaya dâhil edilmiştir. Yirmi çalışma, okul çalışanlarına yönelik programlar, öğrencilere yönelik programlar, öğrencilere yönelik beceri eğitim programları, tarama programları ve akran destek programları olarak beş temaya ayrılmıştır. Okul çalışanlarına yönelik Uygulamalı İntihara Müdahale Becerileri, Sorgula, İkna Et ve Sevk Et ve İntiharı Önlemede Eğitimcilerle Ortak Çalışma programları; öğrencilere yönelik İntiharın Sinyalleri, Ruh Sağlığına Duyarlı Gençler ve Gençleri Yaşatma programı, beceri eğitimine yönelik Dikkate al, Değerlendir, Müdahale Et ve Güçlendir programı, tarama programları ve Gücün Kaynağı akran destek programı incelenmiştir. Bu programlar amacı, içeriği, program süresi, araştırma modeli, örneklem sayısı ve bulgular kapsamında incelenmiştir. Elde edilen bulgular, intihar önleme programlarının geliştirilmesinde ruh sağlığı uzmanları ve üniversitelerle iş birliği çalışmalarının yapılması ve okullarda hizmetiçi eğitim faaliyetlerinin gerçekleştirilmesi gerektiğini göstermektedir.
Optimasi Kinerja Alat Fourier Transform Infrared (FTIR) Melaui Studi Perbandingan Komposisi dan Ketebalan Sampel-KBr
Authors: Subamia I Dewa Putu , Widiasih Ni Nyoman , Sri Wahyuni I Gusti Ayu Nyoman , Pratami Kristiyanti Putu Lilik
Published: July 2023

Problems often occur in sample testing using the FTIR instrument, one of which is that the spectrum quality of the measurement results is not optimal. This has implications for the accuracy of the test results. This condition indicates that the performance of the tool is not optimal. The non-optimal quality of this spectrum is thought to be influenced by the composition factor and the thickness of the sample-KBr which is measured not in accordance with the legibility limits of the instrument. To overcome this problem, it is important to conduct a study to find out the optimum composition and thickness of the KBr-sample which can be measured properly by the instrument. The purpose of this study was to optimize the performance of the FTIR device through a study of the optimum composition and thickness of the KBr-sample so that a good spectrum was produced in the sample measurement using FT-IR type IRAffinity-1 Shimadzu. This research is an experimental research with infrared spectrophotometry method, using the One Shot Case Study design. The treatment is a measurement of the variation in the composition of the sample-KBr and the thickness of the sample. The spectrum resulting from the reading of the FT-IR spectrophotometer is interpreted to include wave number and transmittance percent. The results of the readings of each variation are compared with the standard spectrum to see the optimization of the measurement results so that the best spectrum is obtained. The results showed that the optimum ratio of the sample-KBr composition was 4% and the optimum thickness was 1/2 pan.
Computational analysis for wax detection in deepwater pipelines using nuclear techniques
Authors: Leite Nalber Miranda , Lira Carlos Alberto Brayner de Oliveira , Rodriguez Abel Gámez
Published: July 2023

Wax deposition along the extensive oilfield pipelines is a problem that affects the flow assurance. To solve it, one must monitor the wax formation in its initial stage. In this light, nuclear techniques are an effective alternative solution, as they can detect characteristics of materials or substances in an indirect and non-invasive manner. The present work shows a computational model using the MCNP6 (Monte Carlo N-Particle 6) code and the gamma radiation transmission profiling technique to detect different wax thickness. This fact is directly related to the attenuation of the gamma radiation beam when crossing the wax thicknesses.
Review Model-model Evaluasi Program Untuk Pendidikan dan Pelatihan Online
Authors: Faizin Afif , Kusumaningrum Hesti
Published: July 2023

Dalam artikel ini membahas tujuh model evaluasi yang relevan untuk digunakan oleh evaluator dalam program Pendidikan dan pelatihan online. Evaluasi program merupakan kegiatan yang dilakukan secara sistematis dengan tujuan mengumpulkan informasi, menganalisis, dan memberikan penilaian berdasarkan kriteria yang telah ditentukan untuk membantu dalam pengambilan keputusan. Evaluasi program meliputi tiga unsur penting, yaitu: kegiatan yang dilakukan secara sistematis dengan menggunakan kriteria atau standar yang ditetapkan, serta proses pengambilan keputusan. Hasil penelitian ini menunjukkan bahwa evaluasi program memberikan manfaat besar dalam memberikan data dan informasi yang dibutuhkan oleh pengambil kebijakan untuk menentukan kelanjutan program. Evaluasi program juga memberikan data dan informasi yang spesifik pada setiap aspek atau komponen yang dievaluasi, sehingga dapat dijadikan acuan untuk perbaikan program jika memang dibutuhkan. Untuk melakukan evaluasi program secara objektif, perlu dilakukan penelitian evaluative yang mencakup pendidikan dalam kelas maupun online learning. Untuk melakukan evaluasi program para peneliti hendaknya mengacu pada suatu model yang berfungsi untuk memandu, dan memberikan langkah-langkah pelaksanaan evaluasi dengan baik.
River water laboratory processing Protocol v1
Authors: Shrestha Sneha
Published: July 2023

These are the qPCR conditions used for the S. Typhi and Paratyphi qPCR used for environmental surveillance by our lab team
Show Me the Money: Side‐Payments and the Implementation of International Agreements in Federal Systems
Authors: Gómez Johannes Müller
Published: July 2023

Federal systems face specific challenges in fulfilling their international commitments. In cases of shared jurisdiction, the federal government needs the sub-federal level to contribute to the implementation process. Both Canada and the EU have used side-payments to bring and keep on board reluctant and opposing provinces and member states in the implementation of international agreements. However, both cases have experienced the limits of this strategy. This article aims to make a theoretical contribution by identifying the causal conditions and processes that help explain the success and failure of using side-payments to encourage sub-federal support for the implementation of an international agreement. Based on the study of the implementation of the Paris Agreement in Canada and the EU, I develop a two-fold argument. First, side-payments can be an effective tool to persuade sub-federal governments if they are generally interested in contributing to implementation. They do not work for governments of powerful entities that are unwilling to implement. Second, sub-federal governments react to other actors’ conduct. Side-payments can keep reluctant governments of weak entities on board only as long as no alliance of powerful sub-federal entities is formed that resists the implementation of an international agreement.
Yoga and the Healing of Interpersonal Trauma: A Qualitative Meta-Analysis
Authors: Ong Gaffney Isabelle , Gulden Ashley W. , Jennings Len , Page Mackenna L.
Published: July 2023

Although emerging research indicates that yoga facilitates healing from interpersonal trauma, consensus is lacking as to yoga’s main facilitative factors. To address this limitation, we employed qualitative meta-analysis to analyze data from six qualitative studies (n = 105) that examined the healing agents of yoga that facilitated recovery from interpersonal trauma. The analysis process included coding data from each study and analyzing codes across all of the studies to derive meta-categories. Three researchers engaged in dual-level analyses (i.e., both inductive and deductive) to support consistency, address any inconsistencies, and develop a consensus. We identified and categorized six meta-categories based on the original 45 themes from the six studies and found differing levels of convergence across the studies. Meta-categories with high levels of convergence included (1) stabilization: coping strategies to reduce trauma-related symptoms; (2) authenticity, inner attunement, and self-acceptance; (3) equanimity: calming the mind and mindfulness; and (4) community: reduced isolation through safe connection with others. Our findings offer a more integrated, comprehensive, and consolidated understanding of the specific ways yoga can facilitate recovery from interpersonal trauma and demonstrate how qualitative meta-analysis methodology can tie together the richness of similar, stand-alone qualitative studies.
Теоретические основы авторского права в РФ и проблемы защиты прав в сети «интернет»
Authors: Королѐв Д.А.
Published: July 2023

В данной статье приводятся правовые нормы регулирования и реализации авторского права в Российской Федерации, а также характеристика проблемы регулирования авторского права в сети «Интернет».
Komentari čitatelja na novinskim portalima kao oblik participativnog novinarstva
Authors: Zgrabljić Rotar Nada , Kunić Tamara , Josić Ljubica
Published: July 2023

Cilj je rada istražiti komentare čitatelja na tri hrvatska informativna portala (24sata.hr, Index.‎hr i Net.hr) o kontroverznom prijedlogu Muzičke akademije i rektora Zagrebačkog sveučilišta da‎ se tadašnjem zagrebačkom gradonačelniku Milanu Bandiću dodjeli počasni doktorat. U ovom članku ‎komentari se istražuju u okviru teorijskog koncepta digitalne javne sfere i koncepta deliberativno-demokratske ‎javne sfere, prema kojem umreženo društvo participacijom građana, kroz decentraliziranu i‎ interaktivnu komunikaciju, osim komunikacije, transformira i oblikuje odnose moći među ljudima. Metodom ‎kvantitativne analize sadržaja 2852 komentara objavljena u razdoblju od 27. studenoga 2018. do 15.‎travnja 2019. analiziran je odnos između opreme članaka i komentara, provedena je analiza sentimenta‎ kao metoda za skupljanju polariteta emocija za uvid u raspoloženje komentatora (Liu, 2012), a s aspekta‎ Dahlbergovih kategorija (2007), analiziran je doprinos javnoj raspravi. Rezultati pokazuju izrazito negativan ‎stav građana prema prijedlogu o dodjeli počasnoga doktorata zagrebačkom gradonačelniku Milanu‎ Bandiću, čini se da postoji povezanost između negativno intoniranih naslova i fotografija članaka ‎s raspoloženjem komentatora i utvrđena je relativno mala prisutnost neprihvatljivoga govora i govora‎ mržnje, čak i u negativnim komentarima, te niska razina argumentirane rasprave.‎
Etička orijentacija i profesionalne dileme
Authors: Majstorović Dunja , Ivanuš Željana , Vilović Gordana
Published: July 2023

Rad daje prikaz anketnog istraživanja na 243 studenta preddiplomskog i diplomskog studija‎ novinarstva na Fakultetu političkih znanosti Sveučilišta u Zagrebu provedenog s ciljem uvida u stavove‎ studenata o kontroverznim metodama u izvještavanju i najvažnijim etičkim problemima u suvremenom‎ novinarstvu te uvida u njihovu etičku orijentaciju. Istraživanje je također imalo za cilj otkriti potencijalne ‎razlike među studentima različitih razina studija (preddiplomska i diplomska razina), različitog radnog‎ iskustva u medijima te između studenata novinarstva i novinara u Hrvatskoj (usporedba s rezultatima‎ studije Worlds of Journalism Study). ‎Rezultati ne pokazuju razlike između studenata preddiplomskog i diplomskog studija kao ni između‎ onih s iskustvom i bez iskustva rada u medijima u pogledu njihova stava prema korištenju kontroverznih‎ metoda u izvještavanju, ali su pronađene razlike između studenata novinarstva i novinara s obzirom na‎ njihovu etičku orijentaciju. Studenti novinarstva navode otkrivanje identiteta (maloljetnika) i senzacionalizam ‎kao najveće etičke probleme suvremenog novinarstva.‎
Insig1 deletion in proximal tubular deregulates Aldh1a1 to consume NAD+ and contributes to renal fibrosis
Authors: Yu Xiaowen , Li Shumin , Qin Jun , Zhao Yingying , Wang Jiali
Published: July 2023

Profibrotic proximal tubules (PTs) were identified as a unique phenotype of PTCs in renal fibrosis. Controlling the process of renal fibrosis requires understanding how to manage the S1 subset's branch to the S3 subset rather than to the profibrotic PT subset. Insig1 is one of the branch-dependent genes involved in controlling this process, although its role in renal fibrosis is unknown. Here, we discovered the pathogenic effect of PTC-specific Insig1 deficiency on renal fibrosis in vivo and in vitro. Overexpression of Insig1 profoundly inhibited renal fibrosis. Insig1 deletion boosted SREBP1 nuclear localization, increasing Aldh1a1 transcriptional activity, causing excessive NAD+consumption and ER enlargement, and accelerating renal fibrosis. We identified nicardipine as a selective inhibitor of Aldh1a1-restored NAD+and ER homeostasis, which attenuated renal fibrosis. Together, our findings support Insig1 as a new therapeutic target for CKD.