bluuebunny/crossref_metadata_2025 huggingface dataset:
Germline and somatic variants in ovarian carcinoma: A next-generation sequencing (NGS) analysis
Authors: Andrikopoulou Angeliki , Zografos Eleni , Apostolidou Kleoniki , Kyriazoglou Anastasios , Papatheodoridi Alksistis-Maria , Kaparelou Maria , Koutsoukos Konstantinos , Liontos Michalis , Dimopoulos Meletios-Athanasios , Zagouri Flora
Published: December 2022

Background

Germline BRCA1/2 mutations are identified in 13-15% of ovarian cancers, while an additional 5-7% of ovarian cancers harbor somatic BRCA1/2 mutations. Beyond these mutations, germline or somatic aberrations in genes of the homologous recombination (HR) pathway such as RAD51B/C/D, PALB2, ATM, BRIP1 may confer an HR deficiency in up to 50% of ovarian tumors. Next-generation sequencing (NGS) is a high-throughput massive parallel sequencing method that enables the simultaneous detection of several mutations in entire genomes.

Methods

We performed NGS analysis in 86 patients with ovarian cancer treated in the Oncology Department of Alexandra University Hospital in order to identify the molecular landscape of germline and somatic mutations in ovarian cancer.

Results

The genes with the highest number of pathogenic somatic mutations in high grade serous carcinoma (HGSC) patients were TP53 [68%; 34/50] and BRCA1 [22%; 11/50] followed by somatic mutations in RB1 [2%; 1/50], NF1 [2%; 1/50], BRCA2 [2%; 1/50], AKT1 [2%; 1/50], RAD50 [2%; 1/50], PIK3CA [2%; 1/50] genes. Of note, the most common TP53 genetic polymorphism was c.524G>A p.Arg175His in exon 5. Variants of unknown significance (VUS) detected in HGSC included ROS1 [26%; 13/50], RAD50 [6%; 3/50], BRCA2 [6%; 3/50], NOTCH1 [6%; 3/50], TP53 [6%; 3/50], AR [6%; 3/50]. As for germline mutations, BRCA1 [8/30; 27%] and BRCA2 [4/30; 13%] were the most common genes bearing pathogenic alterations in HGSC, while VUS germline mutations commonly affected HRR-related genes, including ATM (c.7816A>G), BRIP (c.2327 C>A), CHEK2 (c.320-5T>A).

Conclusion

Overall, genetic testing should be offered in most patients with ovarian cancer to identify mutations in HRR genes and determine the population that would be susceptible to poly ADP ribose polymerase (PARP) inhibitors.
Development and validation of a predictive model for diagnosing prostate cancer after transperineal prostate biopsy
Authors: Ren Wenming , Xu Yujie , Yang Congcong , Cheng Li , Yao Peng , Fu Shimin , Han Jie , Zhuo Dong
Published: December 2022

Objective

This study aimed to develop and validate a nomogram to predict the probability of prostate cancer (PCa) after transperineal prostate biopsy by combining patient clinical information and biomarkers.

Methods

First, we retrospectively collected the clinicopathologic data from 475 patients who underwent prostate biopsy at our hospital between January 2019 to August 2021. Univariate and multivariate logistic regression analyses were used to select risk factors. Then, we established the nomogram prediction model based on the risk factors. The model performance was assessed by receiver operating characteristic (ROC) curves, calibration plots and the Hosmer–Lemeshow test. Decision curve analysis (DCA) was used to evaluate the net benefit of the model at different threshold probabilities. The model was validated in an independent cohort of 197 patients between September 2021 and June 2022.

Results

The univariate and multivariate logistic regression analyses based on the development cohort indicated that the model should include the following factors: age (OR = 1.056, p = 0.001), NEUT (OR = 0.787, p = 0.008), HPR (OR = 0.139, p < 0.001), free/total (f/T) PSA (OR = 0.013, p = 0.015), and PI-RADS (OR = 3.356, p < 0.001). The calibration curve revealed great agreement. The internal nomogram validation showed that the C-index was 0.851 (95% CI 0.809-0.894). Additionally, the AUC was 0.851 (95% CI 0.809-0.894), and the Hosmer–Lemeshow test result presented p = 0.143 > 0.05. Finally, according to decision curve analysis, the model was clinically beneficial.

Conclusion

Herein, we provided a nomogram combining patients’ clinical data with biomarkers to help diagnose prostate cancers.
Novel use of riociguat in infants with severe pulmonary arterial hypertension unable to wean from inhaled nitric oxide
Authors: Domingo L. T. , Ivy D. D. , Abman S. H. , Grenolds A. M. , MacLean J. T. , Breaux J. A. , Minford K. J. , Frank B. S.
Published: December 2022

Introduction

Riociguat, an oral soluble guanylate cyclase stimulator, has been approved for use in adults with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension. However, there is limited data on its therapeutic use in children.

Case Presentation

We report the case of two infants with severe suprasystemic pulmonary hypertension who were successfully treated with riociguat after failure to wean off inhaled nitric oxide (iNO) despite combination PAH therapy. Case 1 is a 6-month-old term male with TBX4 deletion who presented with severe hypoxemic respiratory failure and severe PAH immediately after birth. Initial cardiac catheterization showed PVRi 15.5 WU*m2. Marked hypoxemia and PAH persisted despite aggressive therapy with sildenafil, bosentan, intravenous treprostinil, and milrinone. The infant required high doses of inhaled nitric oxide (60 ppm) and manifested significant post-ductal hypoxemia and hemodynamic instability with any attempt at weaning. After discontinuation of sildenafil, initiation, and very slow uptitration of riociguat, the patient was able to maintain hemodynamic stability and wean from nitric oxide over 6 weeks with persistently severe but not worsened pulmonary hypertension. Case 2 is a 4-month-old term male with compound heterozygous SLC25A26 mutation and severe pulmonary hypertension. Initial cardiac catheterization showed PVRi 28.2 WU*m2. After uptitration of sildenafil, bosentan, and IV treprostinil, serial echocardiograms continued to demonstrate near-systemic pulmonary hypertension. He failed multiple attempts to wean off typical doses of iNO (10–20 ppm) over the following weeks with tachypnea, hypoxemia, and worsening pulmonary hypertension on echocardiogram despite continued aggressive combination targeted therapy. After a 24-h sildenafil washout, he was initiated and uptitrated on riociguat with concomitant, successful wean of nitric oxide over one week that was well tolerated. No serious adverse effects in the titration period were observed.

Conclusion

Riociguat may be considered as an adjuvant therapeutic agent in selected children with severe PAH who are poorly responsive to sildenafil therapy and unable to wean from iNO.
Efficacy and safety of the dexamethasone implant in vitrectomized and nonvitrectomized eyes with diabetic macular edema: A systematic review and meta-analysis
Authors: Yuan Qiongzhen , Liu Yanling , Gou Yueqin , Xu Hanyue , Gao Yunxia , Liu Yilin , Chen Yi , Zhang Ming
Published: December 2022

Purpose: To compare the efficacy and safety of the intravitreal dexamethasone (DEX) implant for the treatment of diabetic macular edema (DME) in vitrectomized and nonvitrectomized eyes.

Methods: We performed a literature search in four electronic databases (PubMed, EMBASE, MEDLINE, and Cochrane Library) from inception to 22 May 2022. Studies comparing the efficacy of the DEX implant in vitrectomized and nonvitrectomized eyes with DME with at least 3 months of follow-up were included. The main outcomes included comparison of the mean change in the best-corrected visual acuity (BCVA) and central macular thickness (CMT) from baseline to different follow-up endpoints between the vitrectomized and nonvitrectomized groups. The secondary outcomes were the mean duration of action for the first DEX implantation and the number of required injections throughout the follow-up period. Safety data were collected and compared.

Results: The final analysis included 7 studies involving 582 eyes, 208 vitrectomized eyes and 374 nonvitrectomized eyes. The mean between-group differences in BCVA improvement were not significant at any endpoint, with averages difference of −0.07 logarithm of the minimum angle of resolution (logMAR) (p = 0.088) at 1 month, −0.03 logMAR (p = 0.472) 3 months, −0.07 logMAR (p = 0.066) 6 months, and −0.04 logMAR (p = 0.486) 12 months. The mean between-group differences in CMT reduction were not statistically significant, with mean differences of 7.17 μm (p = 0.685) at 1 month, 20.03 μm (p = 0.632) 3 months, −1.80 μm (p = 0.935) 6 months, and −25.65 μm (p = 0.542) 12 months. However, the vitrectomized group had a significantly shorter duration of action during the first DEX implantation than the nonvitrectomized group, with a mean difference of 0.8 months (p = 0.005). No significant between-group differences were detected for the number of required injections or safety profile.

Conclusion: This meta-analysis showed similar efficacy and safety of the sustained-release DEX intravitreal implant for vitrectomized and nonvitrectomized eyes with DME. The intravitreal DEX implant could be considered an effective choice for DME treatment in eyes with prior vitrectomy.
The safety and efficacy of esketamine in comparison to dexmedetomidine during drug-induced sleep endoscopy in children with obstructive sleep apnea hypopnea syndrome: A randomized, controlled and prospective clinical trial
Authors: Yongping Zheng , Xinyi Li , Aming Sang , Qiang Xie , Tianqi Zhou , Mengmeng Shen , Xiong Chen , Xuemin Song
Published: December 2022

Background and Purpose: Data and high-quality studies of anesthetic methods for children with obstructive sleep apnea hypopnea syndrome (OSAHS) who undergo drug-induced sleep endoscopy (DISE) are limited. Research on pediatric DISE using esketamine has never been reported before. To test the safety and efficacy of esketamine during DISE in children with OSAHS, we compare esketamine (Group K) with dexmedetomidine (Group D) in this study.

Methods: 100 children with ASA Ⅰ∼Ⅱ grade, prepared for an elective adenotonsillectomy under general anesthesia, were enrolled in this study and randomized into two groups. Midazolam 0.1 mg/kg was administered intravenously for both groups. In Group D a 1 μg/kg bolus of dexmedetomidine was given over 10 min followed by the infusion rate 1 μg/kg/hr to the end of DISE. Group K received a 1.0 mg/kg IV bolus of esketamine over 10 s followed by the infusion rate 1 mg/kg/hr to the end of DISE.

Results: Group K had a higher percentage of success than Group D (p = 0.008). The onset time of Group K was shorter than that of Group D (p = 0.000). The University of Michigan Sedation Scale (UMSS) score of Group K was higher than that of Group D (p = 0.005). The risk of adverse effects (AEs) was lower in Group K (p = 0.000). In Group D, systolic and diastolic blood pressure (SBP and DBP) and heart rate (HR) all decreased, while in Group K, SBP, DBP, and HR hardly changed.

Conclusion: Esketamine in comparison to dexmedetomidine provides more effective and safer depth of anesthesia for OSAHS pediatric DISE by ensuring short onset time, deep sedation, and few AEs.

Clinical Trial Registration: ClincalTrials.gov, identifier NCT04877639
Precision caffeine therapy for apnea of prematurity and circadian rhythms: New possibilities open up
Authors: Dai Hao-Ran , Guo Hong-Li , Hu Ya-Hui , Xu Jing , Ding Xuan-Sheng , Cheng Rui , Chen Feng
Published: December 2022

Caffeine is the globally consumed psychoactive substance and the drug of choice for the treatment of apnea of prematurity (AOP), but its therapeutic effects are highly variable among preterm infants. Many of the molecular underpinnings of the marked individual response have remained elusive yet. Interestingly, the significant association between Clock gene polymorphisms and the response to caffeine therapy offers an opportunity to advance our understanding of potential mechanistic pathways. In this review, we delineate the functions and mechanisms of human circadian rhythms. An up-to-date advance of the formation and ontogeny of human circadian rhythms during the perinatal period are concisely discussed. Specially, we summarize and discuss the characteristics of circadian rhythms in preterm infants. Second, we discuss the role of caffeine consumption on the circadian rhythms in animal models and human, especially in neonates and preterm infants. Finally, we postulate how circadian-based therapeutic initiatives could open new possibilities to promote precision caffeine therapy for the AOP management in preterm infants.
HIF-1 signalling pathway was identified as a potential new pathway for Icariin’s treatment against Alzheimer’s disease based on preclinical evidence and bioinformatics
Authors: You Mingyao , Yuan Ping , Li Liangqian , Xu Hongbei
Published: December 2022

Aim: Alzheimer’s disease (AD) is a neurodegenerative condition that is characterized by the gradual loss of memory and cognitive function. Icariin, which is a natural chemical isolated from Epimedii herba, has been shown to protect against AD. This research examined the potential mechanisms of Icariin’s treatment against AD via a comprehensive review of relevant preclinical studies coupled with network pharmacology.

Methods: The PubMed, Web of Science, CNKI, WANFANG, and VIP databases were used to identify the relevant studies. The pharmacological characteristics of Icariin were determined using the SwissADME and TCMSP databases. The overlapping targets of Icariin and AD were then utilized to conduct disease oncology (DO) analysis to identify possible hub targets of Icariin in the treatment of AD. The hub targets were then used for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses, and the interactions of the targets and Icariin were assessed via molecular docking and molecular dynamics simulation (MDS).

Results: According to the literature review, Icariin alleviates cognitive impairment by regulating the expression of Aβ1-42, Aβ1-40, BACE1, tau, hyperphosphorylated tau, and inflammatory mediators. DO analysis revealed 35 AD-related hub targets, and the HIF-1 signalling pathway was ranked first according to the KEGG pathway analysis. Icariin effectively docked with the 35 hub targets and HIF-1α, and the dynamic binding of the HIF-1-Icariin complex within 100 ns indicated that Icariin contributed to the stability of HIF-1α.

Conclusion: In conclusion, our research used a literature review and network pharmacology methods to identify the HIF-1 signalling pathway as a potential pathway for Icariin’s treatment against AD.
Characterization and expression profiling of PIN auxin efflux transporters reveal their role in developmental and abiotic stress conditions in rice
Authors: Manna Mrinalini , Rengasamy Balakrishnan , Ambasht Navin Kumar , Sinha Alok Krishna
Published: December 2022

The auxin efflux transporter proteins called PINs ferry auxin from its source to sinks in particular directions depending on their polar localizations in the plasma membrane, thus facilitating the development of the entire plant architecture. The rice genome has 12 PIN genes distributed over eight chromosomes. To study their roles in plant development, abiotic stress responsiveness, and shaping an auxin-dependent root architecture, a genome-wide analysis was carried out. Based on phylogeny, cellular localization, and hydrophilic loop domain size, the PINs were categorized into canonical and noncanonical PINs. PINs were found expressed in all of the organs of plants that emphasized their indispensable role throughout the plant’s life cycle. We discovered that PIN5C and PIN9 were upregulated during salt and drought stress. We also found that regardless of its cellular level, auxin functioned as a molecular switch to turn on auxin biosynthesis genes. On the contrary, although PIN expression was upregulated upon initial treatment with auxin, prolonged auxin treatment not only led to their downregulation but also led to the development of auxin-dependent altered root formation in rice. Our study paves the way for developing stress-tolerant rice and plants with a desirable root architecture by genetic engineering.
Molecular mechanism of leaf adaxial upward curling caused by BpPIN3 suppression in Betula pendula
Authors: Chen Kun , Qu Chang , Zhang Xiao-yue , Wang Wei , Gu Chen-rui , Liu Gui-feng , Yu Qi-bin , Yang Chuan-ping , Jiang Jing
Published: December 2022

Leaves are one of the vegetative organs of plants that are essential for plant growth and development. PIN-FORMED (PINs) gene is an indoleacetic acid (IAA) transporter that plays a critical role in leaf development. To determine the function of BpPIN3 in leaf polarity formation in Betula pendula, the transgenic lines with BpPIN3 overexpression (OE) and BpPIN3-reduced expression (RE) were analyzed using the Agrobacterium-mediated method. The RE lines displayed the characteristics of leaf margin adaxial upward curling, with lower expression of BpPIN3 resulting in greater rolling. Tissue localization of IAA in the auxin GUS reporter system proved that auxin in the RE was mainly distributed in the secondary veins, palisade tissues, and epidermal cells in the leaf margin area. The auxin content in the leaf margin area was significantly greater than that in the main vein tissue. The cell density of the palisade tissue and the ratio of palisade tissue to spongy tissue in the curled leaf margin of the RE lines were found to be significantly decreased. RNA-seq analysis revealed that the RE hormone-signaling pathway genes were significantly enriched compared with those of the OE and WT lines; in particular, the auxin response-related genes SAURs (i.e., SAUR23, SAUR24, SAUR28, and SAUR50) and GH3.10 were found to be significantly upregulated. qRT-PCR analysis indicated that BpPIN3 expression at the leaf margin was significantly lower than that near the main vein in the RE lines. In contrast, the expression levels of SAURs and GH3.10 were significantly higher than those near the midrib. In conclusion, BpPIN3 regulates the expression of auxin response-related genes and the polar transport of auxin to change the polar form of the proximal and distal axes of birch leaves.
Precipitation and temperature regulate species diversity, plant coverage and aboveground biomass through opposing mechanisms in large-scale grasslands
Authors: Yao Zhenyu , Xin Yue , Yang Liu , Zhao Liqing , Ali Arshad
Published: December 2022

Introduction

Although the relationships between species diversity and aboveground biomass (AGB) are highly debated in grassland ecosystems, it is not well understood how climatic factors influence AGB directly and indirectly via plant coverage and species diversity in large-scale grasslands along a topographic gradient. In doing so, we hypothesized that climatic factors would regulate plant coverage, species diversity and AGB due to maintaining plant metabolic and ecological processes, but the relationship of plant coverage with AGB would be stronger than species diversity due to covering physical niche space.

Methods

To test the proposed hypothesis, we collected data for calculations of species richness, evenness, plant coverage and AGB across 123 grassland sites (i.e., the mean of 3 plots in each site) dominated by Leymus chinensis in northern China. We used a structural equation model for linking the direct and indirect effects of topographic slope, mean annual precipitation and temperature on AGB via plant coverage, species richness, and evenness through multiple complex pathways.

Results

We found that plant coverage increased AGB, but species evenness declined AGB better than species richness. Topographic slope influenced AGB directly but not indirectly via plant coverage and species diversity, whereas temperature and precipitation increased with increasing topographic slope. Regarding opposing mechanisms, on the one hand, precipitation increased AGB directly and indirectly via plant coverage as compared to species richness and evenness. On the other hand, temperature declined AGB indirectly via plant coverage but increased via species evenness as compared to species richness, whereas the direct effect was negligible.

Discussion

Our results show that niche complementarity and selection effects are jointly regulating AGB, but these processes are dependent on climatic factors. Plant coverage promoted the coexistence of species but depended greatly on precipitation and temperature. Our results highlight that precipitation and temperature are two key climatic drivers of species richness, evenness, plant coverage and AGB through complex direct and indirect pathways. Our study suggests that grasslands are sensitive to climate change, i.e., a decline in water availability and an increase in atmospheric heat. We argue that temperature and precipitation should be considered in grassland management for higher productivity in the context of both plant coverage and species diversity which underpin animals and human well-being.
Area-based management tools to protect unique hydrothermal vents from harmful effects from deep-sea mining: A review of ongoing developments
Authors: Blanchard Catherine , Gollner Sabine
Published: December 2022

The deep seabed in areas beyond national jurisdiction, or what is referred to as “the Area,” is the common heritage of humankind, safeguarded by mandating the International Seabed Authority (ISA) to protect the marine environment and to regulate all mining-related activities on the seabed in areas beyond national jurisdiction. So far, the ISA has 7 contracts for polymetallic sulfide (PMS) exploration. PMS deposits are located at and near deep-sea hydrothermal vents, one of the most remarkable ecosystems on Earth. Where hot and mineral rich vent fluids escape from the earth's crusts, minerals precipitate and are deposited, and unique biomass rich microbial and animal communities are thriving. Several intergovernmental organizations suggest that active vents classify as areas in need of conservation. The ISA is currently developing regional environmental plans for PMS and has set some first steps to protect active vents from mining impacts. We review the current regulatory and policy framework for deep-sea spatial management, and set it into the environmental context. We conclude that all current management measures of the ISA would not be suited to protect the marine environment from harmful mining impact. We recognize that ISA's area-based management tools are under development, and suggest that improvements can be achieved by studying and recognizing the ecological attributes of ecosystems and their connectivity, as well as governance connectivity, taking into account area-based management tools of different users in the same area.
Sensory-processing sensitivity versus the sensory-processing theory: Convergence and divergence
Authors: Turjeman-Levi Yaara , Kluger Avraham N.
Published: December 2022

Two individual-difference theories focus on sensory sensitivity: one emanating from psychology—sensory-processing-sensitivity (SPS); and one from occupational therapy—sensory processing theory (SP). Each theory is coupled with its measure: the highly-sensitive-person scale (HSPS) and the adolescent adult sensory profile (ASP). The constructs of both theories were claimed to be independent of neuroticism. To assess the convergence of these measures, we recruited participants from a general population and a Facebook Group dedicated to people high in SPS. The participants,N = 1,702Mage = 26.9 (66.7% female), answered the HSPS, ASP, and neuroticism questionnaires. We subjected the HSPS and the APS to exploratory graph analysis. To assess the divergence of these measures from neuroticism, we performed meta-analyses. We also used a subsample obtained in an unrelated study,N =490, to correlate HSPS and APS with the Big Five and additional measures. The results suggested that (a) the latent structure of these measures conforms to the theories only partially, (b) some of the sub-scales of these two measures correlated highly,r = 0.63, but low enough to suggest divergence, (c) both differentially predict membership in a Facebook group, and (d) both are not isomorphic with neuroticism. We concluded that HSPS primarily measures theemotionalreaction to sensory stimulation, whereas ASP thebehavioralreactions. We offer shorter yet reliable measures for both theories.
Assessing the role of organic food supply chain traceability on food safety and consumer wellbeing: A mediated-moderation investigation
Authors: Guanqi Zhou , Husnain Mudassir
Published: December 2022

Introduction/Purpose

Drawing on dynamic capabilities theory, this study offers a comprehensive framework for examining the relationships between organic food supply chain traceability, consumer wellbeing, and food safety trust based in organic food sector. The study also explores how consumer awareness of organic food influences the relationship between consumer wellbeing and food safety. We also look at a mediated moderation mechanism in the relationships stated earlier.

Methods

Using a survey as the primary data collecting method, a total of 221 usable responses were collected. To test the hypothesized relationships between all variables, SPSS PROCESS Macro 3.3 is utilized.

Results

The findings show that the organic food traceability OFSC affect food safety trust and food safety and consumer wellbeing are positively associated, while consumer awareness of organic food acts as a moderator on the relationship between food safety trust and consumer wellbeing. Also consumer awareness conditionally influences the strength of the indirect relationship between OFST and consumer wellbeing via food safety, thereby indicates a mediated moderation mechanism among the study variables.

Discussion/Implications

This study clarifies how consumer food safety trust and organic food traceability can enhance their wellbeing. It contributes to the theory of dynamic capabilities as well as organic traceable product marketing strategies.
The relationship between basic psychological needs satisfaction and university students’ academic engagement: The mediating effect of emotional intelligence
Authors: Chen Hongxia , Zhang Morning Hon
Published: December 2022

Introduction

Basic psychological needs satisfaction (BPNS) and Emotional intelligence (EI) have been underscored as helpful psychological constructs in explaining academic engagement. However, the joint interaction of BPNS with EI abilities to explain academic engagement has not been tested. Therefore, the present study aimed to investigate the interactive role of BPNS with EI abilities in the prediction of academic engagement in a sample of Chinese university students.

Methods

A questionnaire survey was administered to a sample of 466 university students. The data were analyzed using the SPSS (version 21.0) software. The first analysis consisted of descriptive statistics (including mean and standard deviation) and Pearson’s correlations among BPNS, EI, and academic engagement. Through structural equation modeling (SEM), direct and indirect effects were calculated.

Results

The results showed that BPNS was positively associated with academic engagement and that only the Use of emotion dimension of EI mediated these associations.

Discussion

These results suggest that important interventions incorporated with BPNS and EI abilities, especially the use of emotion ability, may be performed to promote university students’ academic engagement.
Evaluating the impact of employees’ perception of identity threat on knowledge sharing behavior during COVID-19: The mediation and moderation effect of social capital and reward system
Authors: Peng Michael Yao-Ping
Published: December 2022

Quarantine policies introduced in the context of COVID-19 are affecting business operations and slowing down the flow rate of the overall economy. Different degrees and types of threats occur in both the living environment and the working environment during the epidemic prevention, which causes many additional uncertainties. The impact on employees is the identity threat from environment and organizations. This is different from the related research on the identification and impact of the threat before the occurrence of COVID-19. However, in the post-pandemic period, companies continue to strengthen important factors that can increase innovation and recovery, including the role of employee knowledge sharing. The organizational inequity and lack of organizational justice bring about the threat of internal identification in organizations. In order to ensure their own interests in organizations, employees may think twice when sharing knowledge. Therefore, this study explores the relationship among employees’ identity threat, social capital and knowledge sharing behavior from the perspective of organizational behavior. In this study, a sample of high-tech employees was conducted, and a total of 434 questionnaires were obtained. The research results show that employees’ perception of identity threat has a negative impact on knowledge sharing behavior and positively affects social capital; employees’ social capital positively affects their knowledge sharing behaviors; and organizational reward system moderates the relationship between identity threat and knowledge sharing behavior. Based on the comprehensive research findings, this research proposes corresponding theoretical and practical implications.
The impact of public responses toward healthcare workers on their work engagement and well-being during the Covid-19 pandemic
Authors: Shan Wen , Wang Zhengkui , Su Millie Yun
Published: December 2022

Introduction/context

Healthcare workers (HCWs) play an important role in fighting against the COVID-19 pandemic. However, they have been exposed to mixed public responses more significantly during the COVID-19 pandemic, which have potentially affected their work and life.

Aim

We aim to study what public responses toward HCWs existed, how and why such public responses impacted HCW’s work engagement and well-being, and how Human Resource (HR) professionals navigate these impacts. These understandings are important for improving HCWs’ work and life quality.

Methods

We adopted a mixed approach including both quantitative and qualitative methods to investigate how the public responses impact HCWs’ work engagement and well-being and how human resource management (HRM) shall intervene. Our quantitative study enables us to collect and analyze a large amount of public responses toward HCWs from the social media platform during the COVID-19 pandemic globally, and uncover the sentiments and topics of these pubic responses via big data and AI technologies. Our qualitative study allows us to understand how and why these public responses impact HCWs’ work engagement and well-being via interviews and further identify how HR professionals shall navigate these impacts.

Results

The sentiment analysis showed that 55.9% of the discussions toward HCWs were positive, 27.2% were neutral, and 16.9% were negative. The topic modeling analysis indicated that the commonly identified topics were related to fear (the negative responses) and gratitude (the positive responses). The interviews with 18 HCWs revealed that HCWs’ work engagement and well-being were decreased by negative public responses through experiencing tension or disappointment due to social and physical ostracism, rejection, discrimination, and criticism. On the other hand, positive public responses in terms of encouragement, recognition, and tangible donations increased their work engagement and well-being. The analysis also suggested that occupational calling served as a mechanism that explained why public responses had such impacts on HCWs. The interview results also highlighted the significance of HRM in bridging positive public responses toward HCWs and revealed problems with communication from HRM during the pandemic. This research provides practical implications about how to improve HCWs work engagement and well-being during the pandemic via public and HRM efforts.
Extremely preterm children and relationships of minor neurodevelopmental impairments at 6 years
Authors: Niutanen Ulla , Lönnberg Piia , Wolford Elina , Metsäranta Marjo , Lano Aulikki
Published: December 2022

Aim

This study investigated minor impairments in neurological, sensorimotor, and neuropsychological functioning in extremely preterm-born (EPT) children compared to term-born children. The aim was to explore the most affected domains and to visualize their co-occurrences in relationship maps.

Methods

A prospective cohort of 56 EPT children (35 boys) and 37 term-born controls (19 boys) were assessed at a median age of 6 years 7 months with Touwen Neurological Examination, Movement Assessment Battery for Children, 2nd edition (MABC-2), Sensory Integration and Praxis Test (SIPT), and a Developmental Neuropsychological Assessment, 2nd edition (NEPSY-II). Altogether 20 test domains were used to illustrate the frequency of impaired test performances with a bar chart profile and to construct relationship maps of co-occurring impairments.

Results

The EPT children were more likely to perform inferiorly compared to the term-born controls across all assessments, with a wider variance and more co-occurring impairments. When aggregating all impaired test domains, 45% of the EPT children had more impaired domains than any term-born child (more than five domains, p < 0.001). Relationship maps showed that minor neurological dysfunction (MND), NEPSY-II design copying, and SIPT finger identification constituted the most prominent relationship of co-occurring impairments in both groups. However, it was ten times more likely in the EPT group. Another relationship of co-occurring MND, impairment in NEPSY-II design copying, and NEPSY-II imitation of hand positions was present in the EPT group only.

Interpretation

Multiple minor impairments accumulate among EPT children at six years, suggesting that EPT children and their families may need support and timely multi-professional interventions throughout infancy and childhood.
A potential tool for predicting epidemic trends and outbreaks of scrub typhus based on Internet search big data analysis in Yunnan Province, China
Authors: Wang Zixu , Zhang Wenyi , Lu Nianhong , Lv Ruichen , Wang Junhu , Zhu Changqiang , Ai Lele , Mao Yingqing , Tan Weilong , Qi Yong
Published: December 2022

Introduction

Scrub typhus, caused by Orientia tsutsugamushi, is a neglected tropical disease. The southern part of China is considered an important epidemic and conserved area of scrub typhus. Although a surveillance system has been established, the surveillance of scrub typhus is typically delayed or incomplete and cannot predict trends in morbidity. Internet search data intuitively expose the public's attention to certain diseases when used in the public health area, thus reflecting the prevalence of the diseases.

Methods

In this study, based on the Internet search big data and historical scrub typhus incidence data in Yunnan Province of China, the autoregressive integrated moving average (ARIMA) model and ARIMA with external variables (ARIMAX) model were constructed and compared to predict the scrub typhus incidence.

Results

The results showed that the ARIMAX model produced a better outcome than the ARIMA model evaluated by various indexes and comparisons with the actual data.

Conclusions

The study demonstrates that Internet search big data can enhance the traditional surveillance system in monitoring and predicting the prevalence of scrub typhus and provides a potential tool for monitoring epidemic trends of scrub typhus and early warning of its outbreaks.
Association of household fuel with acute respiratory infection (ARI) under-five years children in Bangladesh
Authors: Islam Md. Aminul , Hasan Mohammad Nayeem , Ahammed Tanvir , Anjum Aniqua , Majumder Ananya , Siddiqui M. Noor-E-Alam , Mukharjee Sanjoy Kumar , Sultana Khandokar Fahmida , Sultana Sabrin , Jakariya Md. , Bhattacharya Prosun , Sarkodie Samuel Asumadu , Dhama Kuldeep , Mumin Jubayer , Ahmed Firoz
Published: December 2022

In developing countries, acute respiratory infections (ARIs) cause a significant number of deaths among children. According to Bangladesh Demographic and Health Survey (BDHS), about 25% of the deaths in children under-five years are caused by ARI in Bangladesh every year. Low-income families frequently rely on wood, coal, and animal excrement for cooking. However, it is unclear whether using alternative fuels offers a health benefit over solid fuels. To clear this doubt, we conducted a study to investigate the effects of fuel usage on ARI in children. In this study, we used the latest BDHS 2017–18 survey data collected by the Government of Bangladesh (GoB) and estimated the effects of fuel use on ARI by constructing multivariable logistic regression models. From the analysis, we found that the crude (the only type of fuel in the model) odds ratio (OR) for ARI is 1.69 [95% confidence interval (CI): 1.06–2.71]. This suggests that children in families using contaminated fuels are 69.3% more likely to experience an ARI episode than children in households using clean fuels. After adjusting for cooking fuel, type of roof material, child's age (months), and sex of the child–the effect of solid fuels is similar to the adjusted odds ratio (AOR) for ARI (OR: 1.69, 95% CI: 1.05–2.72). This implies that an ARI occurrence is 69.2% more likely when compared to the effect of clean fuel. This study found a statistically significant association between solid fuel consumption and the occurrence of ARI in children in households. The correlation between indoor air pollution and clinical parameters of ARI requires further investigation. Our findings will also help other researchers and policymakers to take comprehensive actions by considering fuel type as a risk factor as well as taking proper steps to solve this issue.
β-glucan from brewer’s spent yeast as a techno-functional food ingredient
Authors: Gautério Gabrielle Victoria , Silvério Sara Isabel Da Cruz , Egea Mariana Buranelo , Lemes Ailton Cesar
Published: December 2022

Brewer’s spent yeast (BSY) is a by-product generated during beer production. After heat inactivation, large quantities of BSY are discarded or sold as a low-cost animal feed supplement. Fortunately, BSY can be a good source of valuable compounds such as β-glucan, which has several biological and techno-functional properties for application as a food ingredient. Practical application of β-glucan from BSY requires disruption cell wall and purification steps that significantly influences the yield, cost, biological, physic-chemical, and technological characteristics of this compound. This mini-review presents the use of BSY as a source of β-glucan, the available methods to extract it, and its biological and techno-functional properties.
A review of the applications of multi-agent reinforcement learning in smart factories
Authors: Bahrpeyma Fouad , Reichelt Dirk
Published: December 2022

The smart factory is at the heart of Industry 4.0 and is the new paradigm for establishing advanced manufacturing systems and realizing modern manufacturing objectives such as mass customization, automation, efficiency, and self-organization all at once. Such manufacturing systems, however, are characterized by dynamic and complex environments where a large number of decisions should be made for smart components such as production machines and the material handling system in a real-time and optimal manner. AI offers key intelligent control approaches in order to realize efficiency, agility, and automation all at once. One of the most challenging problems faced in this regard is uncertainty, meaning that due to the dynamic nature of the smart manufacturing environments, sudden seen or unseen events occur that should be handled in real-time. Due to the complexity and high-dimensionality of smart factories, it is not possible to predict all the possible events or prepare appropriate scenarios to respond. Reinforcement learning is an AI technique that provides the intelligent control processes needed to deal with such uncertainties. Due to the distributed nature of smart factories and the presence of multiple decision-making components, multi-agent reinforcement learning (MARL) should be incorporated instead of single-agent reinforcement learning (SARL), which, due to the complexities involved in the development process, has attracted less attention. In this research, we will review the literature on the applications of MARL to tasks within a smart factory and then demonstrate a mapping connecting smart factory attributes to the equivalent MARL features, based on which we suggest MARL to be one of the most effective approaches for implementing the control mechanism for smart factories.
The rejuvenation of urban community in China under COVID-19
Authors: Xie Linjun , Shao Mengqi
Published: December 2022

The persistent COVID-19 pandemic has continuously brought the basic level of urban governance to the forefront. Urban community governance in China involves both state-led and civil society-led governance. Whilst previous studies have noted the weak civil society and delocalization in modern China, recent research reveals the re-localization trend shown during the pandemic. In this brief research report, we seek to provide a detailed account of the hyper-local dynamism within civil society in responding to the public health emergency, focusing on the thriving spontaneous groups in Shanghai during the COVID-19 outbreak in March and April 2022. By dissecting the multi-level, multi-actor governance, we reveal the significant roles played by spontaneous groups in complementing state-led governance and in building united urban communities in combatting the worst effects of COVID-19. We outline the types and organizational structure of various spontaneous groups. We also critically reflect on their implications and potential in advancing urban community governance in China. We argue that there is an imperative need to further explore how these spontaneous groups can catalyze transformative changes that can for example empower grassroots actors and motivate wider public participation in community decision-making.
A comparative analysis of the proximate and mineral composition of whole Citrus limon and Citrus clementina as a prospective alternative feed resource for livestock farming in South Africa
Authors: Idamokoro Emrobowansan Monday , Hosu Yiseyon Sunday , Oyedeji Opeoluwa Oyehan , Miya Gugulethu Mathews , Kuria Simon Kamande , Oyedeji Adebola Omowunmi
Published: December 2022

Citrus is a well-known vital fruit grown in South Africa. The presence of important bio-nutrients and metabolites within the different Citrus fruits indicates their significant nutritional qualities. This study is aimed to evaluate the proximate and mineral components of whole Citrus limon and Citrus clementina while considering them as prospective feed material for livestock farmers in South Africa. The nutritional evaluation was done using standard analytical procedures of the Association of Official Analytical Chemists (AOAC). The mineral constituents of the whole citrus samples were analyzed using inductively coupled plasma optical emission spectroscopy (ICP-OES). From the result, the nutritional analysis showed that the whole C. limon contains significantly higher moisture content (14.13 ± 0.57) and fiber content (24.48 ± 0.61) than C. clementina (11.41 ± 1.24 and 20.66 ± 1.07). Meanwhile, C. clementina had a significantly higher protein value (8.65 ± 0.04) compared to C. limon (5.53 ± 0.10). Furthermore, the whole C. clementina had significantly higher K, Na, P, Zn, and Na+/K+ (1513.33 ± 16.99, 53.33 ± 4.71, 160.00 ± 0.00, 4.80 ± 0.00, and 1.09 ± 0.01) than the whole C. limon (1356.67 ± 20.55, 30.00 ± 0.00, 133.33±4.71, 1.67 ± 0.09, and 0.80 ± 0.02), respectively. While C. limon had significantly higher Ca, Mg, Mn, and Fe (593.33 ± 4.71, 160.00 ± 0.00, 1.00 ± 0.00, and 4.53 ± 0.25) compared to C. clementina (483.33 ± 4.71, 136.67 ± 4.71, 0.80 ± 1.11, and 3.43 ± 0.05). The study revealed variations in some nutritional and mineral components of whole C. limon and C. clementina; however, both citrus fruits have the potential to be explored for more significant livestock nutritional use in South Africa.
Gender-aware inclusive value chain: A theoretical perspective
Authors: Kini Janvier
Published: December 2022

Achieving SDG5 requires an analytical and practical framework enabling a win–win participation of women with poor resources in gender-blind societies. Women with poor resources are mostly excluded from formal economic systems and face gender inequalities. In agricultural and food value chains, women are not equally included as men in highly attractive value chains, so they end up engaging in informal (less lucrative) agri-food activities alongside the value chains. However, the existing literature fails to design an adequate framework that efficiently addresses gender inequality and the poverty conditions of women in low-income countries, mostly gender-blind. This study contributes to filling this knowledge gap by proposing a gender-aware inclusive value chain from a theoretical perspective. For this purpose, we conducted a deep and extensive state-of-the-art study on value chain development and strategies over the past three decades. Two main types of value chains are drawn from this literature review: (1) conventional value chains, mainly exclusive or adverse, including the bottom of the pyramid populations and gender-blind; and (2) gender-aware value chains mostly focus on value chains that are controlled by women. Hence, the paper proposes a third type of value chains inspired by the Foucauldian perspective of human being: gender-aware inclusive value chain (GAIVC). This perspective considers a value chain similar to the human body in its functioning because the human body is composed of different organs that are autonomous but complementary to each other. GAIVC is also composed of different elements (actors/stakeholders, farms, storage, infrastructure, and so on) that should be complementary and non-competitive. From this perspective, it provides more opportunities for poor resource women to evolve into a non-discriminatory environment based on gender. It also breaks down the power relations between the chain actors, as they have to cooperate and avoid the chain from collapsing from within and outside threats. In this way, the sustainability of value chains is guaranteed, and all actors involved receive fair rewards from chain participation.
Treatment of digital dermatitis using salicylic acid in European bison (Bison bonasus) reveals promising results
Authors: Jucker Simone , Alsaaod Maher , Steiner Adrian , Zingre Tatiana , Kaessmeyer Sabine , Gurtner Corinne , Friker Brian , Brandt Sabine , Jensen Tim K. , Hoby Stefan
Published: December 2022

Digital dermatitis (DD) associated with the presence of multipleTreponemaspp. was recently described for the first time in European bison (Bison bonasus). DD is characterized by skin inflammation in the distal foot area in various ungulates. The objective of this proof of concept study was to test a treatment protocol adopted from cattle for its applicability in this wildlife species using five animals. Keratolytic salicylic acid paste was administered topically under bandages for seven days to enable removal of the affected skin. All interventions were performed under general anesthesia. To evaluate the treatment efficacy, photographs and biopsies were taken pre- and post-treatment. The biopsies were examined histologically, by PCR for the presence of different bacterial species, byTreponema-specific fluorescentin situhybridization (FISH), and by transmission electron microscopy. Based on photographs, complete clinical healing of the 15 feet with macroscopical DD lesions was achieved. Histological examination showed mild to moderate dermatitis in 17/20 feet before, and in 12/20 feet after treatment. 17/20 feet wereTreponemaspp. PCR positive before, and none was positive after treatment.Dichelobacter nodosus, Fusobacterium necrophorum, andPorphyromonas leviicould not be detected in any of the samples. By FISH and electron microscopy,Treponemaspp. could be visualized in the stratum corneum before, but not after treatment. These results suggest that this treatment method can be applied as standard practice prior to transporting DD affected European bison to prevent the spread of this contagious disease.