bluuebunny/crossref_metadata_2025 huggingface dataset:
Figure S4 from Neutralizing Antibodies Impair the Oncolytic Efficacy of Reovirus but Permit Effective Combination with T cell–Based Immunotherapies
Authors: Groeneveldt Christianne , Kinderman Priscilla , Griffioen Lisa , Rensing Olivia , Labrie Camilla , van den Wollenberg Diana J.M. , Hoeben Rob C. , Coffey Matt , Loghmani Houra , Verdegaal Els M.E. , Welters Marij J.P. , van der Burg Sjoerd H. , van Hall Thorbald , van Montfoort Nadine
Published: March 2024

Figure S4. Neutralizing antibodies are required to prevent Reo-induced weight loss and viremia.
Figure S12 from Neutralizing Antibodies Impair the Oncolytic Efficacy of Reovirus but Permit Effective Combination with T cell–Based Immunotherapies
Authors: Groeneveldt Christianne , Kinderman Priscilla , Griffioen Lisa , Rensing Olivia , Labrie Camilla , van den Wollenberg Diana J.M. , Hoeben Rob C. , Coffey Matt , Loghmani Houra , Verdegaal Els M.E. , Welters Marij J.P. , van der Burg Sjoerd H. , van Hall Thorbald , van Montfoort Nadine
Published: March 2024

Figure S12. Influx of immune cells after intratumoral Reo or VSV treatment of KPC3 tumors in Reo-preexposed or VSV-preexposed mice.
Supplementary table 1 from An NFAT1-C3a-C3aR Positive Feedback Loop in Tumor-Associated Macrophages Promotes a Glioma Stem Cell Malignant Phenotype
Authors: Zhang Yaochuan , Song Yifu , Wang Xiaoliang , Shi Mengwu , Lin Yibin , Tao Dongxia , Han Sheng
Published: March 2024

Primer and sequences
Supplementary Figure 7 from An NFAT1-C3a-C3aR Positive Feedback Loop in Tumor-Associated Macrophages Promotes a Glioma Stem Cell Malignant Phenotype
Authors: Zhang Yaochuan , Song Yifu , Wang Xiaoliang , Shi Mengwu , Lin Yibin , Tao Dongxia , Han Sheng
Published: March 2024

Expression of TIM-3 in tumor-associated macrophages and its correlation with glioma clinical characteristics.
Supplementary Figure 5 from An NFAT1-C3a-C3aR Positive Feedback Loop in Tumor-Associated Macrophages Promotes a Glioma Stem Cell Malignant Phenotype
Authors: Zhang Yaochuan , Song Yifu , Wang Xiaoliang , Shi Mengwu , Lin Yibin , Tao Dongxia , Han Sheng
Published: March 2024

Expression of C3AR1 in tumor-associated macrophages and its correlation with glioma clinical characteristics.
Supplementary Figure Legends from FcγRIIB Is an Immune Checkpoint Limiting the Activity of Treg-Targeting Antibodies in the Tumor Microenvironment
Authors: Knorr David A. , Blanchard Lucas , Leidner Rom S. , Jensen Shawn M. , Meng Ryan , Jones Andrew , Ballesteros-Merino Carmen , Bell Richard B. , Baez Maria , Marino Alessandra , Sprott David , Bifulco Carlo B. , Piening Brian , Dahan Rony , Osorio Juan C. , Fox Bernard A. , Ravetch Jeffrey V.
Published: March 2024

Legends
Supplementary Figure 3 from FcγRIIB Is an Immune Checkpoint Limiting the Activity of Treg-Targeting Antibodies in the Tumor Microenvironment
Authors: Knorr David A. , Blanchard Lucas , Leidner Rom S. , Jensen Shawn M. , Meng Ryan , Jones Andrew , Ballesteros-Merino Carmen , Bell Richard B. , Baez Maria , Marino Alessandra , Sprott David , Bifulco Carlo B. , Piening Brian , Dahan Rony , Osorio Juan C. , Fox Bernard A. , Ravetch Jeffrey V.
Published: March 2024

Antitumor activity of Fc-engineered human anti-CTLA-4 antibodies
Supplementary Figure 2 from FcγRIIB Is an Immune Checkpoint Limiting the Activity of Treg-Targeting Antibodies in the Tumor Microenvironment
Authors: Knorr David A. , Blanchard Lucas , Leidner Rom S. , Jensen Shawn M. , Meng Ryan , Jones Andrew , Ballesteros-Merino Carmen , Bell Richard B. , Baez Maria , Marino Alessandra , Sprott David , Bifulco Carlo B. , Piening Brian , Dahan Rony , Osorio Juan C. , Fox Bernard A. , Ravetch Jeffrey V.
Published: March 2024

Biological activity of the anti-murine CD4 antibody GK1.5 harboring a human IgG1 Fc
Figure S7 from Intragenic Rearrangement Burden Associates with Immune Cell Infiltration and Response to Immune Checkpoint Blockade in Cancer
Authors: Zhang Han , Lee Sanghoon , Muthakana Renee R. , Lu Binfeng , Boone David N. , Lee Daniel , Wang Xiao-Song
Published: March 2024

Figure S7. Survival plots of patients stratified based on TMB levels of platinum-naïve or platinum-exposed tumors in the IMVigor210 dataset. (a) Kaplan Meier curves of patients stratified based on TMB levels in platinum-naïve tumors. (b) Kaplan Meier curves of patients stratified based on TMB levels in platinum-exposed tumors. All patients were treated with platinum, but the tumor samples were collected either before platinum treatment (platinum-naïve) or after platinum treatment (platinum-exposed). P-values of log-rank tests are shown in the bottom left for each panel.
Supplementary Fig. 1C from LILRB3 Supports Immunosuppressive Activity of Myeloid Cells and Tumor Development
Authors: Huang Ryan , Liu Xiaoye , Kim Jaehyup , Deng Hui , Deng Mi , Gui Xun , Chen Heyu , Wu Guojin , Xiong Wei , Xie Jingjing , Lewis Cheryl , Homsi Jade , Yang Xing , Zhang Chengcheng , He Yubo , Lou Qi , Smith Caroline , John Samuel , Zhang Ningyan , An Zhiqiang , Zhang Cheng Cheng
Published: March 2024

Supplementary Fig. 1C with figure legend
Supplementary Fig. 1B from LILRB3 Supports Immunosuppressive Activity of Myeloid Cells and Tumor Development
Authors: Huang Ryan , Liu Xiaoye , Kim Jaehyup , Deng Hui , Deng Mi , Gui Xun , Chen Heyu , Wu Guojin , Xiong Wei , Xie Jingjing , Lewis Cheryl , Homsi Jade , Yang Xing , Zhang Chengcheng , He Yubo , Lou Qi , Smith Caroline , John Samuel , Zhang Ningyan , An Zhiqiang , Zhang Cheng Cheng
Published: March 2024

Supplementary Fig. 1A with figure legend
Supplementary Tables from Immune-Related Colitis Is Associated with Fecal Microbial Dysbiosis and Can Be Mitigated by Fecal Microbiota Transplantation
Authors: Elkrief Arielle , Waters Nicholas R. , Smith Natalie , Dai Angel , Slingerland John , Aleynick Nathan , Febles Binita , Gogia Pooja , Socci Nicholas D. , Lumish Melissa , Giardina Paul A. , Chaft Jamie E. , Eng Juliana , Motzer Robert J. , Mendelsohn Robin B. , Markey Kate A. , Zhuang Mingqiang , Li Yanyun , Yang Zhifan , Hollmann Travis J. , Rudin Charles M. , van den Brink Marcel R.M. , Shia Jinru , DeWolf Susan , Schoenfeld Adam J. , Hellmann Matthew D. , Babady N. Esther , Faleck David M. , Peled Jonathan U.
Published: March 2024

Supplemental Tables S1-S5
Figure S3 from T-cell States, Repertoire, and Function in Classical Hodgkin Lymphoma Revealed through Single-Cell Analyses
Authors: Chen Xiufen , Yu Jovian , Venkataraman Girish , Smith Sonali M. , Chen Mengjie , Cooper Alan , Tumuluru Sravya , Brody Joshua D. , Godfrey James , Kline Justin
Published: March 2024

Supplemental Figure S3. Single cell profiles of selected genes across T cell clusters from all samples
Figure S3 from Immune-Related Colitis Is Associated with Fecal Microbial Dysbiosis and Can Be Mitigated by Fecal Microbiota Transplantation
Authors: Elkrief Arielle , Waters Nicholas R. , Smith Natalie , Dai Angel , Slingerland John , Aleynick Nathan , Febles Binita , Gogia Pooja , Socci Nicholas D. , Lumish Melissa , Giardina Paul A. , Chaft Jamie E. , Eng Juliana , Motzer Robert J. , Mendelsohn Robin B. , Markey Kate A. , Zhuang Mingqiang , Li Yanyun , Yang Zhifan , Hollmann Travis J. , Rudin Charles M. , van den Brink Marcel R.M. , Shia Jinru , DeWolf Susan , Schoenfeld Adam J. , Hellmann Matthew D. , Babady N. Esther , Faleck David M. , Peled Jonathan U.
Published: March 2024

Figure S3
Data from Neutralizing Antibodies Impair the Oncolytic Efficacy of Reovirus but Permit Effective Combination with T cell–Based Immunotherapies
Authors: Groeneveldt Christianne , Kinderman Priscilla , Griffioen Lisa , Rensing Olivia , Labrie Camilla , van den Wollenberg Diana J.M. , Hoeben Rob C. , Coffey Matt , Loghmani Houra , Verdegaal Els M.E. , Welters Marij J.P. , van der Burg Sjoerd H. , van Hall Thorbald , van Montfoort Nadine
Published: March 2024

Abstract
Reovirus type 3 Dearing (Reo), manufactured for clinical application as pelareorep, is an attractive anticancer agent under evaluation in multiple phase 2 clinical trials for the treatment of solid tumors. It elicits its anticancer efficacy by inducing both oncolysis and intratumoral T-cell influx. Because most people have been preexposed to Reo, neutralizing antibodies (NAb) are prevalent in patients with cancer and might present a barrier to effective Reo therapy. Here, we tested serum of patients with cancer and healthy controls (n = 100) and confirmed that Reo NAbs are present in >80% of individuals. To investigate the effect of NAbs on both the oncolytic and the immunostimulatory efficacy of Reo, we established an experimental mouse model with Reo preexposure. The presence of preexposure-induced NAbs reduced Reo tumor infection and prevented Reo-mediated control of tumor growth after intratumoral Reo administration. In B cell–deficient mice, the lack of NAbs provided enhanced tumor growth control after Reo monotherapy, indicating that NAbs limit the oncolytic capacity of Reo. In immunocompetent mice, intratumoral T-cell influx was not affected by the presence of preexposure-induced NAbs and consequently, combinatorial immunotherapy strategies comprising Reo and T-cell engagers or checkpoint inhibitors remained effective in these settings, also after a clinically applied regimen of multiple intravenous pelareorep administrations. Altogether, our data indicate that NAbs hamper the oncolytic efficacy of Reo, but not its immunotherapeutic capacity. Given the high prevalence of seropositivity for Reo in patients with cancer, our data strongly advocate for the application of Reo as part of T cell–based immunotherapeutic strategies.
Data from Intragenic Rearrangement Burden Associates with Immune Cell Infiltration and Response to Immune Checkpoint Blockade in Cancer
Authors: Zhang Han , Lee Sanghoon , Muthakana Renee R. , Lu Binfeng , Boone David N. , Lee Daniel , Wang Xiao-Song
Published: March 2024

Abstract
Immune checkpoint blockade (ICB) can induce durable cancer remission. However, only a small subset of patients gains benefits. While tumor mutation burden (TMB) differentiates responders from nonresponders in some cases, it is a weak predictor in tumor types with low mutation rates. Thus, there is an unmet need to discover a new class of genetic aberrations that predict ICB responses in these tumor types. Here, we report analyses of pan-cancer whole genomes which revealed that intragenic rearrangement (IGR) burden is significantly associated with immune infiltration in breast, ovarian, esophageal, and endometrial cancers, particularly with increased M1 macrophage and CD8+ T-cell signatures. Multivariate regression against spatially counted tumor-infiltrating lymphocytes in breast, endometrial, and ovarian cancers suggested that IGR burden is a more influential covariate than other genetic aberrations in these cancers. In the MEDI4736 trial evaluating durvalumab in esophageal adenocarcinoma, IGR burden correlated with patient benefits. In the IMVigor210 trial evaluating atezolizumab in urothelial carcinoma, IGR burden increased with platinum exposure and predicted patient benefit among TMB-low, platinum-exposed tumors. Altogether, we have demonstrated that IGR burden correlates with T-cell inflammation and predicts ICB benefit in TMB-low, IGR-dominant tumors, and in platinum-exposed tumors.
Abstract P30: Therapeutic activation of pre-B-cell receptor signaling in high-risk pediatric ALL: exploiting TCF3 and MYC-linked vulnerabilities
Authors: Leo Isabelle R , Post Frederik , Struyf Nona , Qi Xuekang , Aswad Luay , Nguyen Thao TT , Tamai Minori , Akahane Koshi , Pokrovskaja-Tamm Katja , Erkers Tom , Inukai Takeshi , Lehtiö Janne , Jafari Rozbeh
Published: March 2024

High-risk pediatric Acute Lymphoblastic Leukemia (ALL) is insufficiently addressed by current treatment options, and generally patients may benefit from safety and efficacy improvements if eligible for targeted therapies. Using a comprehensive panel of 84 pediatric ALL cell lines representing diverse molecular phenotypes, we developed a platform combining multi-omics profiling and drug response screening to link these molecular phenotypes with mechanisms of treatment response. Our results revealed that PKC activation leads to significant toxicity for specific cell line models, with an especially notable efficacy in cells harboring MEF2D rearrangements and TCF3-HLF fusions. We conducted a comprehensive analysis using quantitative, functional and chemical proteome profiling to investigate the impact of pre-B-cell receptor (BCR) signaling activation, identifying a link between activated pre-BCR signaling toxicity and a TCF3 and MYC driven differentiation program. This vulnerability aligns with observed parallels in apoptosis mechanisms during B- and T- lymphocyte development, suggesting a therapeutic angle that exploits a developmental checkpoint. Further, we observed that resistant cell lines have similar induction of toxicity effector responses during PKC activation, but are protected by induction of TCF3 bHLH domain functions and histone acetylation changes. A synergy screen was conducted between PKC activator bryostatin-1 and 528 clinically approved or investigational oncology compounds, using normal bone marrow responses as a healthy reference. This revealed that non-responsive leukemia cell lines can be sensitized to PKC activation effects when combining PKC activation with epigenetic modifiers, indicating an enhanced therapeutic potential. The activation of pre-BCR signaling is a compelling candidate as a chemotherapy-independent targeted treatment modality, offering a promising new avenue which could be especially relevant in the management of high-risk pediatric ALL subtypes and providing a foundation for further translational investigation. Our cell line profiling resource is an exciting ongoing effort with significant potential for identification and evaluation of new treatment opportunities and the molecular phenotypes underlying sensitivity.

Citation Format: Isabelle R Leo, Frederik Post, Nona Struyf, Xuekang Qi, Luay Aswad, Thao TT Nguyen, Minori Tamai, Koshi Akahane, Katja Pokrovskaja-Tamm, Tom Erkers, Takeshi Inukai, Janne Lehtiö, Rozbeh Jafari. Therapeutic activation of pre-B-cell receptor signaling in high-risk pediatric ALL: exploiting TCF3 and MYC-linked vulnerabilities [abstract]. In: Proceedings of the Blood Cancer Discovery Symposium; 2024 Mar 4-6; Boston, MA. Philadelphia (PA): AACR; Blood Cancer Discov 2024;5(2_Suppl):Abstract nr P30.
FIGURE 6 from Identification and Characterization of a Small Molecule Bcl-2 Functional Converter
Authors: Kopparapu Prasad R. , Pearce Martin C. , Löhr Christiane V. , Duong Cathy , Jang Hyo Sang , Tyavanagimatt Shanthakumar , O'Donnell Edmond F. , Nakshatri Harikrishna , Kolluri Siva K.
Published: March 2024

Antitumor effects of BFC1108 in an orthotopic breast cancer model. A, BFC1108 inhibits growth of high Bcl-2–expressing MDA-MB-231 TNBC cells in vivo. A total of 106 MDA-MB-231/Bcl-2 cells were implanted in the mammary fat pad of NOD.SCID mice (n = 8 per group). Once palpable tumors were detected, mice were randomized and treated with vehicle or BFC1108 at 100 mg/kg twice a week by intraperitoneal route. Tumor measurements were made with digital calipers twice a week. *, P < 0.05 from day 18 onward. B, The body weights of mice treated with vehicle or BFC1108 in A were measured twice a week. C, Induction of apoptosis of tumor cells by BFC1108 in vivo. Immunofluorescence was performed on frozen tumor sections to determine apoptosis by TUNEL staining. D, BFC1108 induces conformation change of Bcl-2 in tumor tissues. Bcl-2 conformational change was detected by staining with Bcl-2 BH3 antibody. E, Bax activation by BFC1108. Activated Bax was detected using Bax 6A7 antibody in tumor tissues from animals treated with vehicle or BFC1108. F, Activation of caspase-3 by BFC1108. Activated caspase-3 was detected using cleaved caspase-3 antibody in tumor tissues from animals treated with vehicle or BFC1108.
FIGURE 3 from Identification and Characterization of a Small Molecule Bcl-2 Functional Converter
Authors: Kopparapu Prasad R. , Pearce Martin C. , Löhr Christiane V. , Duong Cathy , Jang Hyo Sang , Tyavanagimatt Shanthakumar , O'Donnell Edmond F. , Nakshatri Harikrishna , Kolluri Siva K.
Published: March 2024

BFC1108 activates intrinsic mitochondrial death pathway. A, BFC1108 suppresses the colony-forming ability of MEF cells in a Bcl-2–dependent manner. WT and Bcl-2−/− MEF cells were treated for 48 hours in a medium containing 10% FBS and the colony formation was determined after 2 weeks. B, Quantification of colony formation data shown in A. **, P < 0.01. C, Bax or Bak is required for BFC1108-induced suppression of viability. WT MEF, Bax Knockout (Bax−/− Bak+/+), Bak knockout (Bax+/+ Bak−/−) and double knockout (Bax−/− Bak−/−) MEF cells were treated with 1 µmol/L BFC1108 for 24 hours in 10% FBS medium and viability was assessed using CellTiter-Glo assay. **, P < 0.01; ***, P < 0.001; ns, not significant. D, BFC1108 decreases mitochondrial membrane potential of Bcl-2–expressing H460 lung cancer cells. JC-1 dye was used to stain live H460 cells that were treated with 10 µmol/L BFC1108 for 16 hours in 10% FBS containing medium. Images taken with FITC, and rhodamine filters were overlaid. Cells stained orange have intact mitochondrial outer membrane and the ones turning green have compromised outer membrane indicating loss of membrane potential.
FIGURE 1 from Identification and Characterization of a Small Molecule Bcl-2 Functional Converter
Authors: Kopparapu Prasad R. , Pearce Martin C. , Löhr Christiane V. , Duong Cathy , Jang Hyo Sang , Tyavanagimatt Shanthakumar , O'Donnell Edmond F. , Nakshatri Harikrishna , Kolluri Siva K.
Published: March 2024

Bcl-2–dependent effects of BFC1108. A, Structure of BFC1108 (5-chloro-N-(2-ethoxyphenyl)-2-[(4-methoxybenzyol)amino]benzamide). B, Left: Bcl-2 expression in MDA-MB-231 cells transfected with pcDNA control vector (MDA-MB-231/Vector) or Bcl-2 expression vector (MDA-MB-231/Bcl-2) was determined by immunoblotting. Right: Cells were exposed to BFC1108 in a medium containing 10% FBS for 48 hours and viability was determined. ***, P < 0.001. C, Left: Bcl-2 expression in MCF-7 cells transfected with pcDNA control vector (MCF-7/Vector) or Bcl-2 expression vector (MCF-7/Bcl-2) was determined by immunoblotting. Right: Cells were exposed to BFC1108 in a medium containing 10% FBS for 48 hours and viability was determined. **, P < 0.01. D, Left: Bcl-2 expression in Jurkat cells transfected with control vector (Jurkat/Vector) or Bcl-2 expression vector (Jurkat/Bcl-2) was determined by immunoblotting. Right: Cells were exposed to BFC1108 in a medium containing 10% FBS for 48 hours and viability was determined. ***, P < 0.001. E, Left: Knockdown of Bcl-2 in MDA-MB-468 cells was determined by immunoblotting. Right: Bcl-2 siRNA and control siLuc siRNA transfected MDA-MB-468 cells were treated with BFC1108 in a medium containing 10% FBS for 48 hours. *, P < 0.05.
Endoscopic Hemostatic Treatment with a Novel Self-Assembling Peptide Gel for Precut Fistulotomy-Related Bleeding
Authors: Kubo Kimitoshi , Zhang Xinhan , Tanaka Ikko
Published: March 2024

Introduction: Precut fistulotomy is of interest as one of the salvage techniques for selective bile duct cannulation using endoscopic retrograde cholangiopancreatography. Of the various endoscopic treatments reported to date for bleeding associated with papillotomy incision, endoscopic hemostasis treatment with a novel self-assembling peptide (SAP) matrix-forming gel (TDM-621) (3-D Matrix Ltd., Tokyo, Japan) remains only insufficiently reported in the literature. Case Presentation: We herein report 6 cases of precut fistulotomy-related bleeding successfully treated with endoscopic hemostasis treatment with TDM-621, i.e., 5 and 1 cases during and after precut fistulotomy, respectively, in 2 males and 4 females aged 68–96 years (mean age, 85 years), 3 of whom had been on antithrombotic drugs. Types of bleeding treated included oozing bleeding (n = 5) and oozing bleeding from a visible vessel (n = 1). In all cases, complete hemostasis was achieved with TDM-621 without causing rebleeding. Conclusion: Endoscopic hemostasis with TDM-621 may prove effective for precut fistulotomy-related bleeding and represent a potential modality of first choice in hemostasis. In addition, endoscopic hemostasis with combined modality therapy using TDM-621 and endoscopic hemoclips may prove effective for bleeding from visible vessels.
Comparing Efficacies of Different Exercises on Androgen Deprivation Therapy Adverse Effects in Prostate Cancer Patients: A Network Meta-Analysis
Authors: Hu Siping , Xiong Xingyu , Qiu Shi , Li Jiakun , Xu Hang , Zhou Xianghong , Wang Sheng , Wei Qiang , Yang Lu
Published: March 2024

Introduction: Previous studies showed exercise have efficacies for androgen deprivation therapy (ADT) adverse effects. To compare the efficacies of different exercises on ADT adverse effects, we conducted the network meta-analysis (NMA). Methods: Literature retrieval was performed in PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL). Nineteen studies (1,184 participants) were included. All analyses were performed in R 4.1.2 or RevMan 5.4.1. Results: NMA results showed that compared with the control group, both aerobic + resistance training (ART) (MD = 5.92, 95% CI: 0.38; 11.46) and resistance exercise (RE) (MD = 5.62, 95% CI: 2.70; 8.55) improved quality of life (QoL). ART (P score: 0.72) may have superiority over RE (P score: 0.7). ART (MD = −10.89, 95% CI: −17.67; −4.11) significantly improved the performance of 400-m test. RE could significantly improve leg strength (MD = 118, 95% CI: 78.75; 157.25) and chest strength (MD = 13.30, 95% CI: 4.07; 22.53). RE ranked first for strength improvements of leg and chest. Conclusion: ART showed better efficacy for the QoL and significantly improved the performance of 400-m test. RE might be superior for the strengths of leg and chest. ART may be appropriate for patients with less significant muscle strength decline but also other adverse effects of ADT, such as decreased cardiopulmonary function.
Toward Heart-Healthy and Sustainable Cities: A Policy Statement From the American Heart Association
Authors: Rajagopalan Sanjay , Ramaswami Anu , Bhatnagar Aruni , Brook Robert D. , Fenton Mark , Gardner Christopher , Neff Roni , Russell Armistead G. , Seto Karen C. , Whitsel Laurie P. ,   on behalf of the American Heart Association Council on Hypertension; Council on Lifestyle and Cardiometabolic Health; Council on Peripheral Vascular Disease; Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Cardiovascular Surgery and Anesthesia; and the American Heart Association Advocacy Coordinating Committee
Published: March 2024

Nearly 56% of the global population lives in cities, with this number expected to increase to 6.6 billion or >70% of the world’s population by 2050. Given that cardiometabolic diseases are the leading causes of morbidity and mortality in people living in urban areas, transforming cities and urban provisioning systems (or urban systems) toward health, equity, and economic productivity can enable the dual attainment of climate and health goals. Seven urban provisioning systems that provide food, energy, mobility-connectivity, housing, green infrastructure, water management, and waste management lie at the core of human health, well-being, and sustainability. These provisioning systems transcend city boundaries (eg, demand for food, water, or energy is met by transboundary supply); thus, transforming the entire system is a larger construct than local urban environments. Poorly designed urban provisioning systems are starkly evident worldwide, resulting in unprecedented exposures to adverse cardiometabolic risk factors, including limited physical activity, lack of access to heart-healthy diets, and reduced access to greenery and beneficial social interactions. Transforming urban systems with a cardiometabolic health–first approach could be accomplished through integrated spatial planning, along with addressing current gaps in key urban provisioning systems. Such an approach will help mitigate undesirable environmental exposures and improve cardiovascular and metabolic health while improving planetary health. The purposes of this American Heart Association policy statement are to present a conceptual framework, summarize the evidence base, and outline policy principles for transforming key urban provisioning systems to heart-health and sustainability outcomes.
Behavioral Bias for Exploration Is Associated with Enhanced Signaling in the Lateral and Medial Frontopolar Cortex
Authors: Güldener Lasse , Pollmann Stefan
Published: March 2024

Should we keep doing what we know works for us, or should we risk trying something new as it could work even better? The exploration–exploitation dilemma is ubiquitous in daily life decision-making, and balancing between the two is crucial for adaptive behavior. Yet, we only have started to unravel the neurocognitive mechanisms that help us to find this balance in practice. Analyzing BOLD signals of healthy young adults during virtual foraging, we could show that a behavioral tendency for prolonged exploitation was associated with weakened signaling during exploration in central node points of the frontoparietal attention network, plus the frontopolar cortex. These results provide an important link between behavioral heuristics that we use to balance between exploitation and exploration and the brain function that supports shifts from one tendency to the other. Importantly, they stress that interindividual differences in behavioral strategies are reflected in differences in brain activity during exploration and should thus be more in the focus of basic research that aims at delineating general laws governing visual attention.
The Role of Letter–Speech Sound Integration in Native and Second Language Reading: A Study in Native Japanese Readers Learning English
Authors: Yan Dongyang , Seki Ayumi
Published: March 2024

The automatic activation of letter–speech sound (L-SS) associations is a vital step in typical reading acquisition. However, the contribution of L-SS integration during nonalphabetic native and alphabetic second language (L2) reading remains unclear. This study explored whether L-SS integration plays a similar role in a nonalphabetic language as in alphabetic languages and its contribution to L2 reading among native Japanese-speaking adults with varying English proficiency. A priming paradigm in Japanese and English was performed by presenting visual letters or symbols, followed by auditory sounds. We compared behavioral and event-related responses elicited by congruent letter–sound pairs, incongruent pairs, and baseline condition (symbol–sound pairs). The behavioral experiment revealed shorter RTs in the congruent condition for Japanese and English tasks, suggesting a facilitation effect of congruency. The ERP experiment results showed an increased early N1 response to Japanese congruent pairs compared to corresponding incongruent stimuli at the left frontotemporal electrodes. Interestingly, advanced English learners exhibited greater activities in bilateral but predominantly right-lateralized frontotemporal regions for the congruent condition within the N1 time window. Moreover, the enhancement of P2 response to congruent pairs was observed in intermediate English learners. These findings indicate that, despite deviations from native language processing, advanced speakers may successfully integrate letters and sounds during English reading, whereas intermediate learners may encounter difficulty in achieving L-SS integration when reading L2. Furthermore, our results suggest that L2 proficiency may affect the level of automaticity in L-SS integration, with the right P2 congruency effect playing a compensatory role for intermediate learners.
Nomenclatural and taxonomic notes on Eugenia (Myrtaceae) from India
Authors: SINGH RAJEEV KUMAR
Published: March 2024

The paper deals with the designation of lectotypes for eight names within the genus Eugenia and provides an explanation of the validity of the lectotypification for the name E. discifera. Additionally, it recognizes E. macrosepala as a distinct species by providing the morphological differences from E. roxburghii.
Phylogenetic position of Vanda coelestis (Rchb.f.) Motes (Orchidaceae; Aeridinae): evidence from complete plastome and combined traditional sequences
Authors: ZENG MENG-YAO , CHEN JIN-LIAO , HUANG MING-ZHONG , LI MING-HE
Published: March 2024

The taxonomic status of Vanda coelestis (Rchb.f.) Motes remains a matter of discussion. So far, molecular systematic work has not been used to investigate. Here, we conducted the phylogenetic analyses using two datasets, the complete plastome and a combination of traditional molecular sequences (nrITS, matK, psbA-trnH, and trnL-trnF). Plastid-based phylogenetic trees indicated that this species was deeply embedded within the genus Vanda. In the analysis based on combined traditional sequences dataset, this species was further supported as sister to V. vietnamica with strong support.
Personality traits and traffic violations: the serial mediating role of theory of planned behavior constructs and intention
Authors: Găianu Pantilimon-Alexandru , Giosan Cezar , Sârbescu Paul
Published: March 2024

Driving behavior is a key factor in traffic accidents. Previous studies have shown a clear link between traffic violations and self-reported road accidents, with intention explaining a large part of the variation in violations. Drawing upon the Theory of Planned Behavior, this study aimed to verify the mediating potential of behavioral, normative, and control beliefs on the relationships between personality traits and traffic violations. A sample of 236 drivers filled out several instruments measuring driving behavior, the Big Five personality traits, and the behavioral, normative, and control beliefs. The beliefs were measured for various behavioral situations conducive to traffic violations, constructed from the Theory of Planned Behavior. We performed a mediation analysis with composite values for the Theory of Planned Behavior constructs as mediator variables. The results showed a fully mediating effect of behavioral beliefs (attitude) and intention in the relationships between neuroticism, agreeableness, or conscientiousness and violations. Normative beliefs (subjective and descriptive) and intention had only a moderate mediating effect in the same relationship pattern. Agreeableness remained associated with violations, even after controlling for normative beliefs. Overall, our results highlight the mediating role of Theory of Planned Behavior constructs in the associations between personality traits and driving behavior. They also suggest that changing behavioral and normative beliefs may reduce the effect of personality traits on violations, which could help design more effective interventions to reduce traffic violations.
Toward an Understanding of Centralized Intertextual Fortification: The Case of Commercially Oriented Qanon Content Creators
Authors: Atkinson Joshua D. , Dorr Matthew , Pedasanaganti Vamsi Chaitanya , Sharma Shudipta
Published: March 2024

In this research, we engaged in a cyber-archaeology of interactive media utilized by Qanon content creators to determine if the concept of diffused intertextual production was present in their work. Most of these content creators were engaged in commercial endeavors with their content. Through our research, we found a communicative strategy similar to diffused intertextual production was utilized by content creators in the Qanon community, but with key differences. We call this emergent strategy centralized intertextual fortification. Our analysis demonstrates that there were different kinds of content creators associated with the Qanon community: intertextual curators, interactive accumulators, and interactive confederates. The first two often “boost” one another and the newer confederates through the content that they produce. In addition, interactivity associated with the various social media and streaming platforms did not allow for followers to take part in the production process as in the case of diffused intertextual production. Instead, the user-to-user interactivity provided by followers of the content creators entailed praise, sharing of virtual objects, and expressions of ideology. Taken together, this centralized use of intertextuality and interactivity allows for these commercially oriented content creators to spread the Qanon intertext, as well as reinforce it through the interactivity of their followers.
Load Carrying Mechanism of Geocell Reinforced Embankment on Soft Soil
Authors: Saikia Rupam , Dash Sujit Kumar
Published: March 2024

This paper investigates the influence of geocell reinforcement on the load carrying mechanism of embankments over soft soil. Using a geocell mattress beneath an embankment on soft soil, the size of the rupture zone in the foundation bed is found to have increased significantly, leading to increase in the mobilized shear resistance, and giving rise to enhanced bearing capacity. While the unreinforced embankment, owing to differential settlements, tends to crack and disintegrate, the geocell reinforced embankment continues to behave as a monolith up to a high surcharge pressure/fill height. The performance improvement tends to increase with increase in height of the geocell mattress. Strain variation in the geocell mattress indicates that its reinforcing efficacy is the largest at the central crest region of the embankment and decreases toward the toe. As the geocell mattress behaves as a semirigid slab, when it is present, the stress dispersion angle tends to increase significantly. Considering the stress dispersion zone as an equivalent rigid footing, the bearing capacity of unreinforced and geocell reinforced embankments are analyzed. The predicted bearing capacities are found to be in close agreement with the experimentally observed ones. Three-dimensional numerical analyses indicate that the pressure–settlement behavior of the embankments observed in the model tests is reproduced at large scale.
Edge-Computing Oriented Real-Time Missing Track Components Detection
Authors: Tang Youzhi , Wang Yi , Qian Yu
Published: March 2024

Track integrity is critical for railroad safety. Traditional track inspections are either labor-intensive or require centralized data processing, making them susceptible to human error and lapses between data collection and situation awareness. The advent of deep learning and computer vision provides promising potential for automated track inspections. However, few existing systems are edge-computing oriented or provide inspection results in real time. In this study, a novel ultra-portable system for real-time detection of track components, such as spikes, bolts, and clips, is developed by integrating the cutting-edge YOLOv8 object detection model with a tailored template matching algorithm. In this system, YOLOv8 serves to recognize track components, while the template matching algorithm discerns missing components based on predefined patterns. Field blind testing results verified the exceptional performance of the model in detecting track components and a remarkable speed of 98.12 frames per second. Leveraging these detection results, the proposed template matching technique displayed an impressive recall rate of 90% and an accuracy rate of 90.77% in identifying missing components. The proposed system provides an affordable and versatile solution for track inspection, aiming to improve railway safety.
The discovery of synchrony: By means of the projector as a scientific instrument
Authors: Watter Seth Barry
Published: March 2024

This article considers the implications for film analysis of the presence or absence of a manual crank. More specifically, it looks at the 16 mm Time and Motion Study Projector as used in behavioral research in the 1960s and 1970s. The controversial concept of ‘interactional synchrony’, or the dance-like coordination of people in conversation, emerged from the use of this hand-turned projector. William S. Condon developed the concept along with the technique of microanalysis. Starting with the projector manufactured by Bell & Howell, he made numerous improvements to facilitate observation—‘sweeping’ over segments of very short duration to discover the rhythmic synchrony of all filmed participants. It led him to a theory of ‘process’ in communication, and in the reception of speech in particular. People always ‘danced’ to the tune of their own voice, and their listeners ‘danced’ to the tune of the speaker—at intervals of one-sixth or one-eighth of a second. This also led Condon to an epistemology of discovery derived partly from philosophy but mostly from his machinery. The universe, he said, is a ‘continuum of order’ whose structures are preserved through translations of order: of thought into speech, speech into vibrations, vibrations into neurons, and back into behavior. The only exceptions are people with disabilities, like the autistics Condon studied from the 1970s onward. But the very distinction of normal and pathological was epiphenomenal to his scanning technique; it was rooted in material and formal qualities of film and of the projector whose crank he turned often.
Experimental analysis of slewing energy recovery potential of large hydraulic excavator
Authors: Shen Chao , Zhu Jianxin , Li Saibai , Dai Peng , Li Xiang
Published: March 2024

Large hydraulic excavators, characterized by large inertia of slewing movement, frequent accelerating and braking, have ideal working conditions for energy recovery and reuse. This paper investigates the slewing energy-saving potential of large hydraulic excavators via experiments conducted under different working conditions. Firstly, the working principle and energy flow of the slewing system of the hydraulic excavator are analyzed, and the evaluation indexes for energy-saving potential are proposed. Additionally, a 50 ton slewing experimental prototype is established, and comparative experiments are conducted. The energy flow analysis demonstrates that the energy loss due to slewing overflow is the primary factor for the low energy utilization rate of the slewing system. Finally, the influence of engine speed, slewing angle, and load on the potential of slewing energy recovery are analyzed. The experiential results reveal that the energy-saving contribution rates of accelerating and braking range from 42% to 45.36% while the energy regeneration rate is 56% under the single-action condition. And the comprehensive contribution rate of accelerating and braking energy is about 9.2% under the compound-action working condition, which has a significant energy-saving potential.
Market Structure, Profitability and Regulation of Telecommunication Industry in India
Authors: Saripalle Madhuri , Somya Surabhi
Published: March 2024

The telecom industry in India has witnessed exponential growth in the past decade; however, its profitability has been on the decline post 2008. This study analyzes the determinants of profitability of the industry during 2010–2022 using the conventional structure-conduct-performance paradigm. We estimate a dynamic panel data model to understand the role of endogeneity and profit persistence in the industry. Our findings are contrary to what the theory predicts and highlight the importance of the regulatory and institutional framework of the industry. Results suggest that there is profit persistence in the industry. The study finds that among conduct variables, export intensity has a positive impact while selling intensity has a negative impact on profitability. While size is not significant, concentration has a negative impact on profitability. Import has a negative impact on profitability. These results suggest that as the telecom industry transitioned from a monopoly to an oligopolistic market with players competing in different domains and services, selling and advertisement intensity has diminishing returns to profitability while export intensity emerges as an important driver of profitability. Results also suggest the importance of the production-linked incentive scheme encouraging exports and the need for regulating concentration and encouraging import substitution.
‘FIRE’ on the horizon. The role of the state in the process of financialization of a national economy
Authors: Laborda Juan , Villena Andrés
Published: March 2024

This paper opens the black box of the role of the state when regulating the process of financialization of a national economy. For this purpose, we firstly study two recent Spanish executives’ closeness and similarity to financial, insurance and real estate sectors – usually identified as the ‘FIRE sector’. We secondly study how the process of specific law production and regulation during two different political terms has significant effects in the finance, insurance, and real estate complex. Our research explains that this specific regulation is related to the evolution of the FIRE sector in Spain, something that reflects the role of state agencies to favour financialization dynamics.
‘Moving on’ for Adults With a Learning Disability and Their Families: A Constructivist Grounded Theory Study
Authors: Taylor Bethany , Thompson Jill , Ryan Tony
Published: March 2024

Ending familial co-residence, termed ‘moving on’ by participants, is an increasingly relevant life transition for people with a learning disability due to increasing life expectancy and policy developments. Nevertheless, there is an absence of research exploring this transition experience in a United Kingdom (UK) context. This constructivist grounded theory study therefore aimed to explore, conceptualise, and theorise the ‘moving on’ experiences of adults with a learning disability and their families. This article reports the experiences of five adults with a learning disability and nine family members in England, UK. Narrative interviews and creative storybook methods were used to collect data between April 2015 and May 2016. Constant comparative methods, theoretical sampling, and memo writing were used throughout data collection and analysis. Participants with a learning disability presented personal growth and greater life fulfilment over the course of the transition; they flourished. In parallel, family members relinquished their care responsibilities. Importantly, the iterative and reciprocal relationship between flourishing and relinquishing shows that ongoing family member involvement is crucial during and following relocation. Family members identified factors that potentially inhibit relinquishing: pressure to ‘let go’, different perceptions of independence between family members and service providers, inadequate future investment, and rapport with professional carers. These novel insights led to the generation of the first known mid-range theory concerning this transition, entitled ‘Moving on: flourishing and relinquishing’. Findings will guide future research in this field and facilitate the design of appropriate support for people with a learning disability and their families.
Gas Leaks, Gas Shutoffs, and Environmental Justice in New York City
Authors: Kucheva Yana , Etemadpour Ronak
Published: March 2024

Gas leaks in cities with older infrastructure are relatively common. The unburned methane which they release is a potent greenhouse gas with harmful health effects. Using administrative municipal data on gas leak reports, we provide a systematic analysis of residential gas leaks in New York City and their association with socioeconomic inequality. We find that both the reporting of gas leaks and the prevalence of resulting residential gas shutoffs is strongly structured by already existing inequalities across neighborhoods. Therefore, we argue that the gas infrastructure in urban areas is an important environmental justice issue as those communities who experience the brunt of failing gas infrastructure are the same communities who have faced decades of disinvestment and environmental racism.
A comparative study on the transbrachial and transfemoral approaches for the treatment of superior mesenteric artery lesions
Authors: Guo Wenying , Chen Li , Li Xiaoye , Zhu Longtu , Zhang Hao , Wu Biao , Lu Qingsheng , Xia Shibo , Ding Zhichen , Zhang Lei
Published: March 2024

Background:

Superior Mesenteric Artery (SMA) lesions present a significant challenge in endovascular surgery. Both the transbrachial (TBA) and the transfemoral (TFA) approaches have been employed for the treatment of these lesions, but the comparative effectiveness of these methods remains unclear.

Materials and methods:

A retrospective analysis was conducted on patients who underwent TBA and TFA at a tertiary center between June 2020 and February 2023. Key parameters including technical success, procedural details, and complication rates were examined.

Results:

In a study of 99 patients, 66 underwent Transfemoral Approach (TFA) and 33 underwent Transbrachial Approach (TBA). No significant age or gender differences were noted between groups. TFA procedures were longer (90.0 vs 63.5 min, p = 0.002) and had higher fluoroscopy times (59.0 vs 43.0 min, p = 0.02) and selective SMA times (366.0 vs 245.0 min, p = 0.038) compared to TBA, especially with a smaller aortomesenteric angle (<90°). Technical success rates were high in both groups (TFA 97%, TBA 93.9%, p = 0.60). Complication rates were similar between groups, with no significant predictors for access site complications identified.

Conclusion:

Both the TBA and the TFA are effective for the treatment of SMA lesions, with TBA potentially offering advantages in terms of efficiency and patient recovery, particularly in cases with certain anatomy. No significant differences in complication rates were found between the two groups. Further research, including prospective randomized trials, is needed to confirm these findings.
Sugar Rush or Sugar Risk? Experiences with Risks and Risk Management among Young Sugar Daters
Authors: Henriksen Theresa Dyrvig , Frøslev-Thomsen Josefine
Published: March 2024

Sugar dating is a complex phenomenon that unfolds on a continuum between traditional dating and sex work. Existing research shows that sugar dating is often portrayed as rife with potential physical and social risks, and from a societal standpoint, it is also often characterized as a risky activity, particularly for young individuals. In this article, we investigate the emergence of these risks and how young sugar daters strategize to minimize them. The findings demonstrate that risk in sugar dating is influenced by complex social and cultural contexts, where especially the stigmatized nature and gendered storyline of sugar dating constitute risks for young sugar daters. These risks are further shaped by the cultural construction of late-modern sexuality, which favours elusive and volatile sexual relations combined with a desire to explore while being young. The young women in this study view sugar dating as a temporary activity that they do not imagine themselves engaging in when they get older. They associate sugar dating with the phase of youth, but unlike other types of youth risk-taking, sugar dating does not occur within the social context of peers. Instead, risk management in the context of sugar dating primarily becomes an individual responsibility, as involving others is perceived as carrying substantial social risks of being labelled as sexually immoral. The study underscores that risk in sugar dating does not exist in a vacuum; rather, it is intertwined with complex social and cultural contexts surrounding sugar dating. By shedding light on these intricate factors, our research contributes to a comprehensive understanding of the lived experiences and dynamics of risk management within the realm of sugar dating.