bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table S4 from A Phase I First-in-Human Study of ABBV-011, a Seizure-Related Homolog Protein 6–Targeting Antibody–Drug Conjugate, in Patients with Small Cell Lung Cancer
Authors: Morgensztern Daniel , Ready Neal , Johnson Melissa L. , Dowlati Afshin , Choudhury Noura , Carbone David P. , Schaefer Eric , Arnold Susanne M. , Puri Sonam , Piotrowska Zofia , Hegde Aparna , Chiang Anne C. , Iams Wade , Tolcher Anthony , Nosaki Kaname , Kozuki Toshiyuki , Li Tianhong , Santana-Davila Rafael , Akamatsu Hiroaki , Murakami Haruyasu , Yokouchi Hiroshi , Wang Song , Zha Jiuhong , Li Rui , Robinson Randy R. , Hingorani Pooja , Jeng Edwin E. , Furqan Muhammad
Published: November 2024

Most Frequent Treatment-Related Adverse Events
Supplementary Figure 8 from GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression
Authors: Stacchiotti Silvia , Martini Silvia , Pasquali Sandro , Frezza Anna M. , Beretta Alessia , Percio Stefano , Lecchi Mara , Tortoreto Monica , Barisella Marta , Collini Paola , Dagrada Gian Paolo , Merlini Alessandra , Huang Paul H. , Jenks Andrew , Jones Robin L. , Tap William D. , Ingrosso Matilde , Morosi Carlo , Brich Silvia , Giani Claudia , Verderio Paolo , Casali Paolo G. , Leonard Hugh , Gronchi Alessandro , Zuco Valentina , Zaffaroni Nadia
Published: November 2024

Supplementary Figure 8. GDF-15 silencing did not impair the proliferative potential of EHE cells as well as their migration and invasion and ability to growth in vivo.
Supplementary Methods S1 from A Phase I First-in-Human Study of ABBV-011, a Seizure-Related Homolog Protein 6–Targeting Antibody–Drug Conjugate, in Patients with Small Cell Lung Cancer
Authors: Morgensztern Daniel , Ready Neal , Johnson Melissa L. , Dowlati Afshin , Choudhury Noura , Carbone David P. , Schaefer Eric , Arnold Susanne M. , Puri Sonam , Piotrowska Zofia , Hegde Aparna , Chiang Anne C. , Iams Wade , Tolcher Anthony , Nosaki Kaname , Kozuki Toshiyuki , Li Tianhong , Santana-Davila Rafael , Akamatsu Hiroaki , Murakami Haruyasu , Yokouchi Hiroshi , Wang Song , Zha Jiuhong , Li Rui , Robinson Randy R. , Hingorani Pooja , Jeng Edwin E. , Furqan Muhammad
Published: November 2024

Definition of dose-limiting toxicities and methods for patient-derived xenograft studies
Supplementary Figure 3 from GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression
Authors: Stacchiotti Silvia , Martini Silvia , Pasquali Sandro , Frezza Anna M. , Beretta Alessia , Percio Stefano , Lecchi Mara , Tortoreto Monica , Barisella Marta , Collini Paola , Dagrada Gian Paolo , Merlini Alessandra , Huang Paul H. , Jenks Andrew , Jones Robin L. , Tap William D. , Ingrosso Matilde , Morosi Carlo , Brich Silvia , Giani Claudia , Verderio Paolo , Casali Paolo G. , Leonard Hugh , Gronchi Alessandro , Zuco Valentina , Zaffaroni Nadia
Published: November 2024

Supplementary Figure 3. Chromosomal architecture of the PDX compared to the clinical sample in chromosomes 7 and 11.
Supplementary Figure 10 from GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression
Authors: Stacchiotti Silvia , Martini Silvia , Pasquali Sandro , Frezza Anna M. , Beretta Alessia , Percio Stefano , Lecchi Mara , Tortoreto Monica , Barisella Marta , Collini Paola , Dagrada Gian Paolo , Merlini Alessandra , Huang Paul H. , Jenks Andrew , Jones Robin L. , Tap William D. , Ingrosso Matilde , Morosi Carlo , Brich Silvia , Giani Claudia , Verderio Paolo , Casali Paolo G. , Leonard Hugh , Gronchi Alessandro , Zuco Valentina , Zaffaroni Nadia
Published: November 2024

Supplementary Figure 10. GDF-15 down-regulation induced by sirolimus and/or ATF4/5 silencing.
Supplementary Table S1 from Long-Term Follow-up of Levonorgestrel Intrauterine Device for Atypical Hyperplasia and Early Endometrial Cancer Reveals Relapse Characterized by Immune Exhaustion
Authors: Bowen Mikayla B. , Melendez Brenda , Zhang Qian , Yang Richard K. , Fellman Bryan M. , Lawson Barrett C. , Adjei Naomi N. , Celestino Joseph , Wani Khalida M. , Singh Bhavana , Urbauer Diana L. , Lazar Alexander J. , Lu Karen H. , Wargo Jennifer A. , Westin Shannon N. , Yates Melinda S.
Published: November 2024

Supplementary Table S1. Representativeness of Study Participants.
Figure 5 from GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression
Authors: Stacchiotti Silvia , Martini Silvia , Pasquali Sandro , Frezza Anna M. , Beretta Alessia , Percio Stefano , Lecchi Mara , Tortoreto Monica , Barisella Marta , Collini Paola , Dagrada Gian Paolo , Merlini Alessandra , Huang Paul H. , Jenks Andrew , Jones Robin L. , Tap William D. , Ingrosso Matilde , Morosi Carlo , Brich Silvia , Giani Claudia , Verderio Paolo , Casali Paolo G. , Leonard Hugh , Gronchi Alessandro , Zuco Valentina , Zaffaroni Nadia
Published: November 2024

Circulating GDF-15 levels correlated with disease aggressiveness in patients with EHE. A, Analysis of circulating cytokines in plasma samples of 16 patients with EHE and four healthy donors using the Human XL Cytokine Array showed higher GDF-15 levels in patients compared with healthy donors. B, GDF-15 levels, as detected by ELISA and expressed in pg/mL plasma, in patients with EHE compared with healthy donors in a training (retrospective; 8 higher-risk and 12 lower-risk patients and 32 healthy donors) and a testing (prospective; 6 higher-risk and 15 lower-risk patients and 32 healthy donors) cohort and in both the cohorts. C, Two clinical cases are reported showing levels of GDF-15 in a lower-risk patient (top) with stable disease at follow-up and a higher-risk patient (bottom) who had an initial tumor response and levels of GDF-15 reduced after being started on the mTOR inhibitor sirolimus followed by an increase in GDF-15 before the CT scan that showed disease progression. PD, progressive disease; SD, stable disease.
Supplementary Figure S1 from Epigenome Reprogramming Through H3K27 and H3K4 Trimethylation as a Resistance Mechanism to DNA Methylation Inhibition in BRAFV600E-Mutated Colorectal Cancer
Authors: Lee Hey Min , Saw Ajay Kumar , Morris Van K. , Napolitano Stefania , Bristow Christopher , Srinivasan Sanjana , Peoples Micheal , Sorokin Alexey , Kanikarla Marie Preeti , Schulz Jonathan , Singh Anand K. , Terranova Christopher , Coker Oluwadara , Jain Abhinav , Kopetz Scott , Rai Kunal
Published: November 2024

Combining anti-EGFR antibodies did not improve response to vemurafenib plus 5-azacitidine treatment.
Supplementary Figure S2 from A First-in-Human Phase I Study of BXQ-350, a First-in-Class Sphingolipid Metabolism Regulator, in Patients with Advanced/Recurrent Solid Tumors or High-Grade Gliomas
Authors: Rixe Olivier , Villano John L. , Wesolowski Robert , Noonan Anne M. , Puduvalli Vinay K. , Wise-Draper Trisha M. , Curry Richard , Yilmaz Emrullah , Cruze Charlie , Ogretmen Besim , Tapolsky Gilles , Takigiku Ray
Published: November 2024

Supplementary Figure S2. Mean percent changes in S1P/C18:1 ratios following BXQ-350 treatment among patients for which samples were available.
Supplementary Table S4 from Chemoradiotherapy and Subsequent Immunochemotherapy as Conversion Therapy in Unresectable Locally Advanced Esophageal Squamous Cell Carcinoma: A Phase II NEXUS-1 Trial
Authors: Wang Xin , Kang Xiaozheng , Zhang Ruixiang , Xue Liyan , Xu Jiaqi , Zhao Xiaotian , Ou Qiuxiang , Yu Nuo , Feng Guojie , Li Jiao , Zheng Ziyu , Chen Xiankai , Wang Zhen , Zheng Qingfeng , Li Yong , Qin Jianjun , Bi Nan , Li Yin
Published: November 2024

Supplementary Table 4. Postoperative complications in patients with R0 resection (n=20)
Supplementary Table S8 from The Epstein–Barr Virus Nuclear Antigen 1 Variant Associated with Nasopharyngeal Carcinoma Defines the Sequence Criteria for Serologic Risk Prediction
Authors: Warner Benjamin E. , Patel Japan , Wang Renwei , Adams-Haduch Jennifer , Gao Yu-Tang , Koh Woon-Puay , Wong Ka Wo , Chiang Alan K.S. , Yuan Jian-Min , Shair Kathy H.Y.
Published: November 2024

Supplementary Table S8. Sensitivity and specificity IgA to EBNA1 constructs by slot blot assay in NPCs <4 years to diagnosis and healthy controls.
Supplementary Table S7 from The Epstein–Barr Virus Nuclear Antigen 1 Variant Associated with Nasopharyngeal Carcinoma Defines the Sequence Criteria for Serologic Risk Prediction
Authors: Warner Benjamin E. , Patel Japan , Wang Renwei , Adams-Haduch Jennifer , Gao Yu-Tang , Koh Woon-Puay , Wong Ka Wo , Chiang Alan K.S. , Yuan Jian-Min , Shair Kathy H.Y.
Published: November 2024

Supplementary Table S7. EBNA1 IgA test-positives by EBV recomLine IgA immunoassay test strip.
Supplementary Figure S2 from ctDNA Dynamics and Mechanisms of Acquired Resistance in Patients Treated with Osimertinib with or without Bevacizumab from the Randomized Phase II ETOP-BOOSTER Trial
Authors: Soo Ross A. , Dafni Urania , Han Ji-Youn , Cho Byoung Chul , Nadal Ernest , Yeo Chong Ming , Carcereny Enric , de Castro Javier , Sala Maria Angeles , Coate Linda , Provencio Mariano , Britschgi Christian , Vagenknecht Patrick , Dimopoulou Georgia , Kammler Roswitha , Finn Stephen P. , Peters Solange , Stahel Rolf A.
Published: November 2024

Supplementary Figure S2. Baseline genomic profile for the N=136 patients constituting the biomarker analysis cohort.
Supplementary Figure S11 from ctDNA Dynamics and Mechanisms of Acquired Resistance in Patients Treated with Osimertinib with or without Bevacizumab from the Randomized Phase II ETOP-BOOSTER Trial
Authors: Soo Ross A. , Dafni Urania , Han Ji-Youn , Cho Byoung Chul , Nadal Ernest , Yeo Chong Ming , Carcereny Enric , de Castro Javier , Sala Maria Angeles , Coate Linda , Provencio Mariano , Britschgi Christian , Vagenknecht Patrick , Dimopoulou Georgia , Kammler Roswitha , Finn Stephen P. , Peters Solange , Stahel Rolf A.
Published: November 2024

Supplementary Figure S11. Overall survival by EGFR del19/L858R mutational status at week 9 (N=107) - landmark analysis (post 9-week time).
Supplementary Table S3 from The Epstein–Barr Virus Nuclear Antigen 1 Variant Associated with Nasopharyngeal Carcinoma Defines the Sequence Criteria for Serologic Risk Prediction
Authors: Warner Benjamin E. , Patel Japan , Wang Renwei , Adams-Haduch Jennifer , Gao Yu-Tang , Koh Woon-Puay , Wong Ka Wo , Chiang Alan K.S. , Yuan Jian-Min , Shair Kathy H.Y.
Published: November 2024

Supplementary Table S3. Reported EBNA1 B cell epitopes with 2+ references from IEDB.org.
Data from Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer
Authors: Dallos Matthew C. , Obradovic Aleksandar Z. , McCann Patrick , Chowdhury Nivedita , Pratapa Aditya , Aggen David H. , Gaffney Christopher , Autio Karen A. , Virk Renu K. , De Marzo Angelo M. , Antonarakis Emmanuel S. , Scher Howard I. , Drake Charles G. , Rathkopf Dana E.
Published: November 2024

AbstractPurpose:
Androgen deprivation therapy (ADT) remains the backbone of prostate cancer treatment. Beyond the suppression of testosterone and tumor cell growth, emerging evidence suggests that ADT also modulates the immune tumor microenvironment. However, a more precise understanding of the timing and intricacies of these immunologic shifts is needed.
Experimental Design:
In this study, we analyzed 49 primary prostate cancers, comparing those surgically removed either without treatment or following treatment with degarelix at 4, 7, and 14 days before surgery. Utilizing next-generation DNA and RNA sequencing and multiplexed immunofluorescence, we examined alterations in immune phenotypes in the presence or absence of ADT.
Results:
Our findings reveal that ADT rapidly transforms the typically bland prostate tumor microenvironment into an inflamed environment within days. Notably, we observed an increase in activated CD8 T cells along with an increase in suppressive regulatory T cells (Treg). We also found an expansion of the myeloid compartment, particularly proinflammatory M1-like tumor-associated macrophages. Intriguingly, discernable changes which have not previously been described also occurred in tumor cells, including upregulation of antigen presentation by MHC classes I and II and, unexpectedly, a decrease in the “do not eat me” signal CD47.
Conclusions:
These observations underscore the critical role of timing and disease context in order to optimize the therapeutic efficacy of immune modulators combined with androgen ablation, for which the presurgical neoadjuvant setting may be ideal. Our findings warrant future prospective validation, which is currently underway.
Data from Cancer in Multilineage Mosaic RASopathies due to Pathogenic Variants in HRAS or KRAS: A Systematic Review and Meta-analysis
Authors: Windrich Jonas , Ney Gina M. , Rosenberg Philip S. , Kim Jung , Zenker Martin , Stewart Douglas R. , Kratz Christian P.
Published: November 2024

AbstractPurpose:
To determine the cancer risk and spectrum in patients with multilineage mosaic RASopathies with pathogenic variants (PV) in HRAS or KRAS.
Experimental Design:
We conducted a systematic literature review to identify multilineage mosaic RASopathy cases with a PV in HRAS or KRAS to create a retrospective cohort. We calculated cumulative incidence, cancer-free survival, and hazard rates for cancer and standardized incidence rates (SIR).
Results:
This study identified 69 patients. Of these, 17% had cancer, including rhabdomyosarcoma (RMS) located in the urogenital region (n = 7), skin cancer (n = 3), Wilms tumor (n = 1), and bladder cancer (n = 1). Cumulative cancer incidence by age 20 was 20% (95% confidence interval, 4%–37%). The annual cancer hazard rate peaked at 14% within the first 2 years of life. The highest SIR was found for RMS (SIR = 800; 95% confidence interval, 300–1648).
Conclusions:
This is the first investigation of cancer risk in KRAS or HRAS PV–positive mosaic RASopathies to date. The high incidence and SIR values found highlight the need for rigorous RMS surveillance in young children and skin cancer surveillance in adults with this high-risk condition.
Вибір методів діагностики при хронічному пародонтиті для клінічних досліджень: структурований огляд
Authors: Лазарєва К. А. , Скрипников П. М. , Кайдашев І. П. , Удальцова К. О. , Шинкевич В. І.
Published: November 2024

Резюме. Необхідність концептуального оновлення клінічної роботи і навчання у сфері періодонтології в Україні диктують відкрита нова спеціальність «Пародонтологія», а також вимоги до дисертацій – публікація статей у міжнародних виданнях Q1, Q2. Але класифікація і діагностика відрізняються від тих, про які повідомляють українські науковці.
Метою дослідження – аналіз методів періодонтальної та додаткової діагностик, які використовують в англомовних і українських наукових статтях, присвячених клінічним випробуванням при періодонтиті/пародонтиті для оптимального їх вибору.
Матеріали і методи. Для огляду було дотримано вказівки PRISMA. Бази даних PubMed і Google Scholar використали для визначення методів діагностики при періодонтиті, які зараз використовують у клінічних випробуваннях. Огляд включав статті за один рік, опубліковані з 2023 р. до 4 серпня 2024 р. Статті добирали за допомогою стратегії пошуку за ключовими словами: «chronic periodontitis clinical trial» та для українських джерел: «хронічний пародонтит клінічне дослідження».
Результати досліджень та їх обговорення. Серед англомовних джерел більшість дизайнів досліджень відповідає рандомізованим контрольованим, що проводяться відповідно до зареєстрованих протоколів. Первинні результати реєструють за такими показниками, як індекс гігієни, додатковий гінгівальний індекс, глибинних вимірювань кишені та рівня прикріплення і кровоточивість ясен. Більшість перерахованих критеріїв оцінює періодонтограма, тому її реєстрація є основою для діагностики, клінічних розрахунків прогнозу та подальшої статистичної обробки. В українських джерелах використовується надмірна кількість показників, яких немає в статтях із міжнародних рецензованих журналів. Навпаки, розділ «Матеріали і методи» не містить інформації про дизайн, рандомізацію, нуль-гіпотезу, та посилання на заздалегідь зареєстровані протоколи, оскільки фахові журнали не вимагають цієї інформації. Автори часто не звертають уваги на порівняння між групами випробувань на кінець випробування, однак це порівняння має значення для вирішальної відповіді на питання про клінічні переваги.
Висновки. Періодонтограма є незамінною основою діагностики при періодонтиті. Самооцінка власного стану пацієнтом необхідна для обʼєктивізації й порівняння. Для математичного урахування багатьох факторів потрібні статистичні методи без усереднення, зокрема, мультиваріантний регресійний аналіз. Необхідні додаткові критерії, які б відображали ефект, оскільки клінічні вимірювання помірно інформативні.
Long-term changes in the French fisheries for crustaceans in the Eastern English Channel: 1901 to 2020
Authors: Amelot Morgane , Schlaich Ivan , Foucher Eric
Published: November 2024

Small-scale crustacean fisheries in the English Channel have existed for centuries but have never been formally assessed; hence, concerns about their ecological and socio-economic sustainability could be raised. This study explores trends in this fishery’s landings from 1901 to 2021, based on historical and recent landings data in two of the main administrative fishing divisions of the area, Cherbourg and Boulogne-sur-Mer quartiers. Crustacean fisheries were reported for both divisions from the beginning to the end of the time period considered, demonstrating that a dedicated crustacean fishery existed in the area since at least the 20th century. The species composition of the crustacean’s catch (e.g., edible crab, Cancer pagurus Linnaeus, 1758; European lobster, Homarus gammarus (Linnaeus, 1758); European spider crab, Maja brachydactyla Balss, 1922) was almost impossible to track before the 2000s. Important fluctuations were observed in catch volume reports along time that might be related to two phenomena: technological advances that would have improved the fishery performances and the decline of some previously targeted species that might have led to a transfer in fishing effort.
Redescription of Metataeniacanthus synodi Pillai, 1963 (Copepoda, Cyclopoida, Taeniacanthidae) recovered from the snakefish (Actinopterygii) in Japan, with the first description of the male of the species
Authors: Izawa Kunihiko
Published: November 2024

Metataeniacanthus synodi Pillai, 1963 is redescribed based on specimens of both sexes recovered from the branchial lamellae of the snakefish, Trachinocephalus myops (Forster, 1801) (Aulopiformes, Synodontidae) in Japan. The description of the male is the first time for the species.
On the identities of Parapleurophrycoides roseus Nobili, 1906 and Platyozius perpusillus Nobili, 1906 (Decapoda, Brachyura): Two problematic French Polynesian species described from juveniles
Authors: Ng Peter K. L.
Published: November 2024

The identities of three brachyuran taxa, Parapleurophrycoides, Parapleurophrycoides roseus and Platyozius perpusillus, newly established by Nobili (1906a) are clarified. The new genus and new species descriptions were based on juveniles from Marutea South in French Polynesia, consequently their taxonomy has been problematic. The only known illustration of Parapleurophrycoides roseus by Nobili (1906b) is small and schematic, while Platyozius perpusillus has never been figured. While various authors have speculated on their taxonomy, others just treat them as nomina dubia. The present study re-examines and figures the types of the two species. While the specimens are small and in poor condition, there are nevertheless enough characters to clearly indicate their familial assignment. Parapleurophrycoides (and its type species, Parapleurophrycoides roseus) is here shown to be closely allied to Viaderiana Ward, 1942, in the Pilumnidae Samouelle, 1819; while Platyozius perpusillus is assigned to the Chlorodiellinae Ng & Holthuis, 2007, in the Xanthidae MacLeay, 1838, although it is not possible to place it in any known genus.
Contemporary Issues of Arbitration under UAE Law
Authors: Masadeh Aymen K. , Alozn Ahmed
Published: November 2024

This paper aims to discuss controversial issues encountered by arbitral tribunals assigned to decide a particular dispute under UAE law. These issues are mainly related to preserving principles of competence-competence and separability, which might adversely affect the validity of the procedures undertaken by arbitral tribunals or the validity of final awards rendered by an arbitral tribunal. The aforementioned problematic scenarios can be noted in the context of the formation of arbitral tribunal, ordering interim, arbitration costs and waiver of arbitration agreement. The study will deploy qualitative legal method, through which an analytical approach will be applied on the UAE Arbitration Law and Dubai International Arbitration Centre (DIAC) Rules in order to illuminate the gaps in both sets that may affect the evidential value of the procedures undertaken in the context of the abovementioned issues. This paper concluded with a set of suggestions aimed at filling the gaps observed in the UAE arbitration Law and DIAC Rules in terms of the aforementioned issues.
Japan’s Society 5.0 and the Organizational Vision of ‘Human-Centric’ AI
Authors: Humphrey David
Published: November 2024

This article examines the Japanese government’s Society 5.0 initiative and its intersection with surveillance based on artificial intelligence (AI). Announced in 2019, Society 5.0 seeks to leverage AI to address Japan’s aging population and other social issues. I examine government documents on the initiative and an example of a smart city project that implements the Society 5.0 vision and, in doing so, highlight a tension between its architects’ proclaimed commitment to socially responsible, ‘human-centric’ uses of AI and the frequent ambiguity of their invocations of the technology. I argue that this lack of a clear definition of AI forestalls an interrogation of the expansive surveillance infrastructure that the initiative would entail. Examining Society 5.0 and its proposed infrastructure, I reveal a schema of digital surveillance and control best characterized as organizational in nature, as it seeks to monitor and coordinate movements, interactions, and behaviours.
Scholarship Across Borders: Thomas Savile’s Translation of Geminus’s Phaenomena
Authors: Philo John-Mark
Published: November 2024

Travelling between the libraries and scholarly coteries of continental Europe (1588–91), Thomas Savile, mathematician and humanist, undertook a translation of Geminus’s Phaenomena, an introduction to astronomy dating from the first century bce. Savile began his translation at Breslau, at the home of Andreas Dudith, and continued to edit his Latin prose at the vast private library of Gian Vincenzo Pinelli at Padua. Here Savile accessed another translation of Geminus, namely Abraham de Balmes’ Latin translation of a Hebrew translation of an Arabic translation of the Greek original. It was through this version and its rich textual history that Savile was able to make some ingenious emendations to the Greek. Savile’s translation was thus a product not only of the rich network of scholars and libraries he was able to access on the Continent, but also of an enduring engagement in northern Italy with Arabic and Hebrew scholarship in Latin translation.
Pathological Examination in Pilonidal Sinus Surgery: Evaluating Necessity and Cost-Effectiveness: A 10-Year Retrospective Analysis
Authors: Kudaş İlyas , Başak Fatih , Çalışkan Yahya K. , Acar Aylin , Tosun Hüsna
Published: November 2024

Background

Malignancy in pilonidal sinus disease (PSD) is rare, with squamous cell carcinoma (SCC) being the most common type. This study aims to assess the incidence of malignancy in PSD and identify risk factors to guide more targeted pathological examination strategies.

Methods

A retrospective analysis was conducted on 1505 patients who underwent surgical excision of PSD between January 1, 2014, and December 31, 2023. Patients with incomplete or missing histopathological data were excluded, and no imputation methods were used for missing data. All specimens underwent histopathological examination to detect malignancies.

Results

Two cases (0.13%) of SCC were identified, both in males aged 50 and 58 years without a history of Crohn’s disease, HIV, prior radiation, or other cancers. Significant risk factors for malignancy included age over 40 years (OR 3.2, 95% CI 1.1-9.5) and disease duration over 3 years (OR 2.8, 95% CI 1.0-7.6). Both cases were treated surgically and received adjuvant radiotherapy, with both patients being disease-free at the 2-year follow-up.

Conclusion

While malignancy in PSD is rare (0.13%), older age and prolonged disease duration are associated with increased risk. Selective pathological examination based on these risk factors could enhance cost-effectiveness by reducing unnecessary routine examinations.
Russia–China Strategic Alignment: Are They Headed Towards a Military Alliance?
Authors: Kumar Rajan
Published: November 2024

In a short span, Moscow and Beijing have transformed their ties from Cold War hostility to a remarkably cordial and dynamic partnership. This transition enables them to expand their regional influence, resist Western pressure and play a dominant role in the Global South. Together, they possess resources, demonstrate determination and have military capability to challenge the superiority of the West. However, their growing strategic cooperation has fuelled speculations about a potential military alliance. This article addresses the following questions: first, how deep is the partnership between the two states? Second, how has US policy contributed to closer ties between the two states? Third, what is the extent of military co-operation between the two states? Are they headed towards a formal military alliance? And finally, how has this partnership fared during the Russia–Ukraine war? This article critically examines policy documents, statements of important leaders and views of experts from Russia, China and the United States. It draws inferences from data on Russia–China economic exchanges, defence agreements and declarations at bilateral and multilateral forums.
Limited Evidence that the Gender Composition of Public Conflicts is Associated with Bystander Intervention: A Video-Observational Study
Authors: van Baak Carlijn , Suonperä liebst Lasse , Rosenkrantz lindegaard Marie
Published: November 2024

Research suggests that the gender composition of conflict parties influences how bystanders perceive violence, reflecting constructions of masculinity and femininity that promote women’s protection. Relying on CCTV footage of public conflicts in the Netherlands, we ran logistic regression models at the situational level ( N = 66 conflicts) and multilevel models at the individual level ( N = 1,954 bystanders) to examine the relationship between conflict parties’ gender composition and bystander intervention. Further, we tested whether perceived intimate ties between conflict parties were associated with intervention. Gender composition was not linked to intervention probability, but patterns in the data point towards less bystander intervention in intimate conflicts, though not statistically clear. Understanding contextual conflict variations is crucial for effective bystander intervention strategies.
Family formation and health-related behavior: The case of meal skipping
Authors: Hara Yuko
Published: November 2024

Using four rounds of nationally representative U.S. panel survey data (NLSY97) and fixed-effects models, this study examines whether and how transitions to marriage/cohabitation/parenthood are associated with gender-specific changes in meal-skipping patterns. Two theoretical perspectives, social control and time scarcity, provide different explanations of how family formation relates to meal skipping. However, empirical research examining the association using a nationally representative sample is scarce. Results indicate that the transitions to romantic relationships (either marriage or cohabitation) are associated with less frequent meal skipping, consistent with social control theory, but in ways that differ by gender. The transition to marriage is associated with reduced meal skipping only for men, whereas the transition to cohabitation is associated with reduced meal skipping to some extent for women. The transition to parenthood has distinctive consequences for women’s meal patterns. Specifically, having two or more children at home is associated with increased meal skipping only for women, which can be explained by the time scarcity perspective. This study reveals that the consequences of family formation on health-related behaviors are gender specific and not universally positive, highlighting women’s persistent role as the primary caregiver for the family.
Durable despite tension: Adult sibling relationships within family figurations
Authors: Luotonen Aino
Published: November 2024

This article analyses adults’ experiences of sibling relationships in the context of the network of family and kin relations – namely, family figurations. In sociological research, there has been growing interest in qualitatively investigating siblings, a theme that was long overshadowed by the interest in intergenerational ties. This study contributes to the discussion on adult sibling relationships as significant and interconnected with other family relationships in individuals’ lives. Drawing upon Elias’ concept of figuration and Smart’s concept of the embeddedness of family relationships, I examine how sibling relationships are experienced in the life stage of family formation. Analysing 32 research interviews with women and men from 16 couples, the article shows three distinct dynamics of how sibling relationships are connected to family figuration. The study contributes to our understanding of how sibling relationships are experienced and lived as embedded within other family relationships. Furthermore, it demonstrates how figuration and embeddedness, two central concepts in family sociology, can be brought together to understand personal relationships in contemporary society.
Burnout during the COVID-19 pandemic in caring professions: The case of social work
Authors: Raya Diez Esther , Cuesta Ruiz-Clavijo Ana Belén , Montenegro Leza Sofia , Carbonero Muñoz Domingo
Published: November 2024

The relationship between burnout and telework was analysed to find out how COVID-19 affected the emotional state of social workers who teleworked during the pandemic, and to analyse the risk of burnout in the field of social services. The fieldwork was conducted on a self-selected sample of 395 social workers in Spain in 2021. The results show a lower risk related to negligent treatment and a high resilience of professionals. The findings highlight the role of social work and the need to organise social services to guarantee the quality of this service without overburdening its professionals.
Factors of Fake News Sharing in the Context of the Ukraine–Russia Conflict: The Effect of Suspicions About European Unions’ Intentions
Authors: Huţul Tudor-Daniel , Holman Andrei Corneliu , Karner-Huţuleac Adina , Huţul Andreea
Published: November 2024

This study examines the separate and joint effects of potential factors of fake news dissemination. A sample of 359 Romanian participants (61.3% female), aged between 18-79 years (M = 45.01; SD = 15.69) filled questionnaires assessing their perceptions of conflict between European Union (EU) and Ukraine; fake news sharing, and various socio-demographic data. Our results revealed that the behaviour of sharing fake news is positively associated with age and more prevalent in men. Also, people who perceive a conflict between EU and Ukraine and thus suspect that behind the EU’s consistent support for Ukraine lies a hidden interest are more inclined to spread fake news. In the female group, age was found to moderate the relationship between perceptions of conflict between EU and Ukraine and fake news sharing. We also discuss the relevance of our findings for public communication efforts aiming to mitigate the dissemination of fake news.
Effects of chamomile oil inhalation on sleep quality in young adults with insomnia: A randomized controlled trial
Authors: Deepa Y. , Vijay A. , Nivethitha L. , Nandhakumar G. , Sathiya S. , Mooventhan A.
Published: November 2024

Objective

Insomnia is characterized by difficulty falling asleep, staying sleep, or both. Aromatherapy is a commonly used complementary and alternative medicine practice by persons with insomnia. Previous studies have shown that use of chamomile oil during massage therapy improves the quality of sleep (QoS). However, to our knowledge, no randomized controlled trials have examined the effects of chamomile oil inhalation on the treatment of insomnia. The present study evaluated the effect of chamomile oil inhalation on QoS and insomnia severity in persons with insomnia.

Methods

A total of 80-participants ages 18-35 with insomnia were randomly allocated to aromatherapy group (AG; n = 40) or a control group (CG; n = 40). Those in the AG group received chamomile oil inhalation, while those in the CG engaged in their normal routine for 10 minutes a day, daily for 15 days. The Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index (ISI) were administered before and after the intervention.

Results

Within-group analysis showed a significant reduction both in PSQI and ISI scores among those in the AG ( P < 0.001 for both scores), whereas the CG reported a significant reduction in PSQI score ( P = 0.033) and no significant changes in ISI score ( P = 0.068). The between groups analysis after the intervention demonstrated a significant reduction in PSQI and ISI scores in the AG group ( P < 0.001 for both) compared to the CG. No participant in either group reported adverse events during or after the study.

Conclusion

Fifteen days of chamomile oil inhalation before bedtime reduced insomnia severity and enhanced the quality of sleep for young adults suffering from insomnia. Further studies are needed to replicate the results of this study using an active control group.
Inclusiveness-Efficiency Configurations of Business Interest Associations with Access to Policymakers
Authors: Albareda Adrià , Saz-Carranza Angel , Federo Ryan
Published: November 2024

This article examines the relationship between business interest associations’ (BIAs’) governance configurations and their access to administrative officials and political heads of the European Union. We focus on how effective BIAs design their plenaries and boards to address the inclusiveness-efficiency tradeoff. By means of a qualitative comparative analysis, we find that most of the configurations related to administrative officials balance efficiency-inclusiveness tensions, one prioritizes inclusion while another focuses on efficiency. As for political heads, EU Commissioners seem to prioritize BIAs that successfully balance these contradictory poles while also paying attention to more inclusive BIAs.
Observer-based adaptive time-varying formation tracking of one-sided Lipschitz nonlinear multi-agent systems
Authors: Wei Ge , Zhan Xisheng , Wu Jie , Wu Bo , Cheng Lingli
Published: November 2024

In this article, the problem of time-varying formation (TVF) tracking for nonlinear multi-agent systems (MASs) is investigated. The agent dynamics are described by one-sided Lipschitz (OSL) and quadratic inner-boundedness (QIB) function. Adaptive continuous TVF tracking protocols for nonlinear MASs are proposed. Compared to prior nonlinear system, this approach is more general and less conservative than nonlinear system with large Lipschitz constant. In addition, the continuous protocols are proposed to avoid undesirable chattering from non-zero inputs of the leader. Finally, the expected theoretical results are achieved through effective numerical simulations.
Dynamic event-triggered adaptive security sliding mode control for singular systems with unknown deception attacks
Authors: Zhang Qian , Yan Huaicheng , Tian Yongxiao , Qi Ping
Published: November 2024

This paper studies the problem of dynamic event-triggered adaptive security sliding mode control (SMC) for singular systems with deception attacks. First, due to limited network resources, a dynamic event-triggered scheme (DETS) is adopted to reduce signal transmission. Second, the deception attacks which make the system unstable are modeled as a nonlinear function. Third, some sufficient conditions are given to assure that the overall system is admissible with [Formula: see text] performance and a method is proposed to design the controller gain and the event-triggered parameter. Fourth, a novel adaptive SMC law is provided to ensure the reaching condition of the sliding surface. Finally, a practical example is employed to show the validity of the designed method.
Replay attack detection based on smooth watermarking and encoding and decoding
Authors: Fu Sha , Li Ping , Sang Hong , Zhao Minxin
Published: November 2024

The proposed detection method in this study, which involves smooth watermarking, encoding, and decoding, aims to address replay attacks in time-delay systems during communication. Implementing an event-triggered technique helps save communication resources and cut down on unnecessary information transmission. A weighted sliding average method is employed to smooth the system’s watermark influenced by time delay, decreasing unnecessary fluctuations and boosting anti-attack resilience. The encoding and decoding systems were ingeniously designed to increase the invisibility of the smooth watermarking, making it more sensitive in detecting replay attacks. Multiple attack scenarios are meticulously examined, after which rigorous simulation tests are carried out to prove the proposed scheme’s reliability, effectiveness, and substantial superiority.
The INS/GPS integrated navigation based on autonomous underwater vehicle using modified extended Kalman filter
Authors: Hou Yudong , Cheng Liang , Wang Qing , Li Jiangxiong , Ke Yinglin
Published: November 2024

Ensuring highhtab accuracy and robustness remains a paramount concern in the realm of underwater positioning and navigation research. This paper proposes a filtering algorithm grounded in Inertial Measurement Unit/Global Positioning System (INS/GPS) integrated navigation to effectively address the challenges posed by non-Gaussian noise, stemming from outliers and measurement inaccuracies. Currently, most filtering algorithms are developed based on the criteria of minimum mean square error (MMSE) or maximum entropy criteria (MCC). To address the challenge of handling complex non-Gaussian noises, this paper uses the Minimum Error Entropy Criterion (MEE) and Extended Kalman Filter (EKF) with Kernel Risk-Sensitive Loss (KRSL) instead of MMSE or MCC to develop an online filtering algorithm with a recursive process, and adjusts the kernel size of MEE within a reasonable range by constructing an adaptive factor to deal with outliers generated during measurement and excessive convergence caused by the inapplicability of the kernel size. Through extensive target tracking simulations and surface Autonomous Underwater Vehicle (AUV) localization experiments, results demonstrate the efficacy of the proposed algorithm. Notably, the algorithm optimizes kernel sizes for different types of noises, ensuring robust state estimation and rapid convergence without compromising filtering accuracy.
Behavioral Addiction Treatment Centers in the Hospitals of Türkiye: A Web-Based Research
Authors: Doğan Keskin Ayten , Öztürk Nuray , Düştü Filiz , Yilmaz Betül
Published: November 2024

This study investigates the current landscape of behavioral addiction treatment in Türkiye hospitals, considering both inpatient and outpatient approaches. The analysis involved examining the websites of 1393 hospitals across Türkiye based on various criteria. The review of the websites was conducted between June and September 2023. The findings reveal that out of these hospitals, comprising 822 public and 571 private institutions, only 51 provide treatment for behavioral addictions. Behavioral addiction treatments are available in 23 of the 81 provinces in Türkiye, and 24 out of the 51 hospitals offering treatment for behavioral addictions are located in İstanbul (47.1%), while three (5.9%) are located in Ankara. Among these 51 hospitals, 22 are public, and 29 are private. The primary focus of treatment revolves around internet and gambling addiction. Upon analyzing the patient groups served, it was observed that 49% ( n = 25) of the hospitals specialize in treating adult patients, while 29.4% ( n = 15) cater to pediatric patients. While the websites of 11 hospitals contain information about the behavioral addiction treatments offered, they lack any information on the patient groups to which they cater. The predominant treatment modalities include psychotherapy (25.49%), followed by psychopharmacotherapy (19.61%) and cognitive-behavioral therapy (17.65%). In conclusion, the treatment of behavioral addictions, such as those related to the internet, gaming, and shopping, are offered in hospitals across various regions and age groups. Considering that only 3.7% of hospitals in Türkiye treat behavioral addictions, this type of treatment is not widespread.
Personality Dimension, Suicidal Intent, and Lethality: A Cross-sectional Study of Suicide Attempters with or Without Personality Disorders
Authors: Sahoo Amruti , Swain Sarada Prasanna , Kar Nilamadhab
Published: November 2024

Background:

Although personality disorders (PD) are known risk factors for suicide attempts, studies on personality dimension are scarce, which may provide further insights for interventions.

Methods:

The relationship between personality dimension, lethality, intent, and quality of life (QOL) was studied in suicide attempters with or without PD. We used the international personality disorder examination (IPDE) dimensional score, the scale for assessment of lethality of suicide attempt (SALSA), suicide intent scale (SIS), and WHOQOL-BREF QOL scale, to assess a sample of suicide attempters admitted to a general hospital.

Results:

PD was present in 43.2% and 57.9% of them had more than one PD. Comparison of attempters with or without PD suggested that the lethality of attempts and QOL were comparable, whereas self-reported suicide intent was significantly low in patients with PD. A higher proportion of PD patients reported relational problems as the reason for the attempt. The personality dimensional score was significantly higher for female attempters from urban backgrounds than for those with previous attempt histories. It was negatively correlated with the lethality of attempts and suicide intent.

Conclusion:

It is important to explore the personality dimension of the suicide attempters, along with PD, that may highlight additional risks and suggest the need for specific support.
Interpersonal Goals and Language Use During the Disclosure of a Concealable Stigmatized Identity: A LIWC Analysis
Authors: Foster Anthony M. , Talley Amelia E.
Published: November 2024

Previous theorizing suggests that the first stage of self-disclosure is the pursuit of an interpersonal goal. However, among individuals disclosing a concealable stigmatized identity, little is known about how their goals impact downstream processes such as language use and post-disclosure affect. Using Linguistic Inquiry and Word Count (LIWC), we examined the extent to which primed self-image or compassionate goals influence the linguistic content and style of disclosure, as well as dyad members’ affective states. Self-image disclosures were high in negative self-focused attention, whereas compassionate disclosures were more inclusive and positive in valence. Moreover, among disclosers, negative emotion words predicted their own negative affect. Among confidants, first-person singular and second-person pronouns predicted negative affect, however, this outcome was inversely related to disclosers’ use of social words. Compassionate goals that seek mutually beneficial outcomes may help disclosers communicate information about their stigma more effectively, and attenuate dyad members’ feelings of emotional distress.
Analysis of pore formation and carburizing mechanism of magnetite reduction by CO
Authors: Zhou Meijie , Ai Liqun , Hong Lukuo , Cui Wenquan , Sun Caijiao , An Weijia , Tong Shuai
Published: November 2024

To investigate the porosity and expansion mechanism of CO-reduced magnetite, the reduced microstructures of magnetite under conventional heating and microwave heating were compared. The microstructure characteristics of magnetite with various reduction degrees were examined in a 60%CO-Ar reduction atmosphere, and the formation and evolution mechanism of the structure were analyzed in conjunction with the reduction effect. The results indicate that the reduction product of CO reduced magnetite possesses a porous structure. Nevertheless, when the gas diffusion is restricted, the reduction process is sluggish and the porous structure is not readily formed. Microwave heating enhances the gas-phase diffusion capacity, thermodynamic carburizing capacity, and solid-phase carbon-oxygen diffusion capacity, resulting in a higher oxygen loss rate than that of conventional heating. Under the experimental conditions, the lattice shrinkage during the Fe3O4 → Fe0.88O transformation and the rapid expansion of Fe0.88O → Fe0.94O are the causes of the crack. Microwaves facilitate the formation of pores and cracks in the product. This study offers a novel concept for the development of foam steel.
Evaluating the Safety Effectiveness of Edge Line Sinusoidal Rumble Strips on Lane Departure Crashes Prevention
Authors: Shindgikar Shubhankar Chintamani , Chen Cong , Lin Pei-Sung , Keita Yaye Mallon , Bialkowska-Jelinska Elzbieta
Published: November 2024

Lane departure crashes are among the most common crashes in the United States and Florida. Various types of rumble strips have been used to prevent or reduce lane departure incidents. The Florida Department of Transportation adopted a new sinusoidal rumble strip pattern for statewide audible and vibratory treatment implementation since recent research reveals that sinusoidal rumble strip patterns are effective in providing auditory and tactile alert to drivers in lane departure prevention and produce less external noise in comparison to other rumble strip texture patterns. However, there has not been a systematic evaluation of the safety effectiveness of sinusoidal rumble strips in the U.S. This paper focused on evaluating the safety effectiveness of edge line sinusoidal rumble strips installed in Florida in recent years through an empirical Bayes approach. Crash data at treatment sites and reference sites were collected, and a series of crash modification factors were developed based on the type of rural roads (overall rural roadways, rural two-lane roads, and rural multi-lane roads) and crash severity levels (total crashes and fatal/SI crashes only). In addition, the authors used a multinomial logit model to estimate the influence of different variables and parameters that affect lane departure crashes. The research findings quantify the safety effectiveness of edge line sinusoidal rumbles strips in preventing lane departure crashes and provide insights on countermeasure implementation to improve rural road safety.