bluuebunny/crossref_metadata_2025 huggingface dataset:
Catalytic center of cytochrome c oxidase: Effects of protein environment on pKa values of cub histidine ligands
Authors: Popovic Dragan , Djordjevic Ivana
Published: August 2020

The molecular mechanism by which electron transfer (ET) is coupled to proton pumping in cytochrome oxidase is one of the main unsolved problems in biochemistry. Particularly, the nature and position of the proton-loading site is under dispute. The CuB complex has three ligated histidines, whereas only His290 and His291 are ionizable sites with the same pKa values in aqueous solution, but apparently quite different ones within the enzyme. Earlier, a model of proton pumping with the central role of His290 was proposed. Recent calculations indicate that the His291 ligand of the CuB center might play the role of the pumping element, since its protonation state depends on the oxidation state of the binuclear complex (BNC). The present electrostatic study was applied to assess the role of the protein environment on the acidity of the two histidines. Their pKa values and effects of different energy terms were evaluated to discover the nature of their diverse behavior in the enzyme. Here, a new set of pKa values for the non-standard model compounds within the BNC was applied. The enhanced results are compared with results of previous studies in the light of the plausible proton pumping mechanism. The obtained microscopic and apparent pKa values in the oxidized state of BNC are virtually the same, indicating that deprotonated form of His291 accounts for the large pKa increase of His290, since then both titratable sites on then CuB center cannot simultaneously be in the charged state. The present results support the underlined His291 pumping model.
Survey of Ultrasound-Guided Peripheral Intravenous Practices: A Report of Supply Usage and Variability Between Clinical Roles and Departments
Authors: Moureau Nancy , Gilbert Gregory E.
Published: August 2020

Highlights

Background: The purpose of this study was to investigate ultrasound-guided peripheral intravenous (UGPIV) supply usage practices by clinicians working in vascular access, in emergency departments (EDs), or in other roles.

Methodology: In 2019, a voluntary cross-sectional descriptive survey was conducted via SurveyMonkey. Data collected included demographics, practice-oriented information, procedural activities, and supplies used for UGPIV insertions. Frequency distributions and results of Fisher’s exact test and one-way analysis of variance were reported using R v.3.5.2.

Results: A total of 26,649 surveys were distributed with a response rate of 5.5% (n = 1475). Forty-eight percent of respondents (n = 709) indicated that they worked in a vascular access role, 310 (21%) worked in an ED, and 455 (31%) categorized their role as other. Clinically meaningful differences existed in all variables for UGPIV procedures and supplies between departments (P < 0.0001) and in all care settings. Using an investigator-constructed overall metric of supplies used, important differences were demonstrated between personnel supply use in vascular access roles and other roles (P < 0.0001) and personnel in EDs and other roles (P < 0.0001).

Conclusions: Use of supplies for UGPIV insertions varies by department. The variability in supply usage for UGPIV insertions revealed by this survey suggests a need for clinical education on guideline application and evaluation of compliance with policies to promote standardization of supplies for UGPIV insertion.
XPR1 Mediates the Pancreatic β-Cell Phosphate Flush
Authors: Barker Christopher J. , Tessaro Fernando Henrique Galvão , Ferreira Sabrina de Souza , Simas Rafael , Ayala Thais S. , Köhler Martin , Rajasekaran Subu Surendran , Martins Joilson O. , Darè Elisabetta , Berggren Per-Olof
Published: August 2020

Glucose-stimulated insulin secretion is the hallmark of the pancreatic β-cell, a critical player in the regulation of blood glucose concentration. In 1974, the remarkable observation was made that an efflux of intracellular inorganic phosphate (Pi) accompanied the events of stimulated insulin secretion. The mechanism behind this “phosphate flush,” its association with insulin secretion, and its regulation have since then remained a mystery. We recapitulated the phosphate flush in the MIN6m9 β-cell line and pseudoislets. We demonstrated that knockdown of XPR1, a phosphate transporter present in MIN6m9 cells and pancreatic islets, prevented this flush. Concomitantly, XPR1 silencing led to intracellular Pi accumulation and a potential impact on Ca2+ signaling. XPR1 knockdown slightly blunted first-phase glucose-stimulated insulin secretion in MIN6m9 cells, but had no significant impact on pseudoislet secretion. In keeping with other cell types, basal Pi efflux was stimulated by inositol pyrophosphates, and basal intracellular Pi accumulated following knockdown of inositol hexakisphosphate kinases. However, the glucose-driven phosphate flush occurred despite inositol pyrophosphate depletion. Finally, while it is unlikely that XPR1 directly affects exocytosis, it may protect Ca2+ signaling. Thus, we have revealed XPR1 as the missing mediator of the phosphate flush, shedding light on a 45-year-old mystery.
XPR1 mediates the pancreatic β-cell phosphate flush
Authors: Admin Ada , Barker Christopher J. , Tessaro Fernando Henrique Galvão , Ferreira Sabrina de Souza , Simas Rafael , Ayala Thais S. , Köhler Martin , Rajasekaran Subu Surendran , Martins Joilson O. , Darè Elisabetta , Berggren Per Olof
Published: August 2020

Glucose-stimulated
insulin secretion is the hallmark of the pancreatic β-cell, a critical player
in the regulation of blood glucose concentration. In 1974 Dawson, Freinkel and
co-workers made the remarkable observation that an efflux of intracellular inorganic
phosphate (Pi) accompanied the events of stimulated insulin
secretion. The mechanism behind this ‘phosphate flush’, its association with
insulin secretion and its regulation have since then remained a mystery. We
recapitulated the phosphate flush in the MIN6m9 β-cell line and pseudoislets.
We demonstrated that knockdown of XPR1, a phosphate transporter present in
MIN6m9 cells and pancreatic islets, prevented this flush. Concomitantly, XPR1
silencing led to intracellular Pi accumulation and a potential impact
on Ca2+ signaling. XPR1 knockdown slightly blunted first phase
glucose-stimulated insulin secretion in MIN6m9 cells, but had no significant
impact on pseudoislet secretion. In keeping with other cell types, basal Pi
efflux was stimulated by inositol pyrophosphates and basal intracellular Pi
accumulated following knockdown of inositol hexakisphosphate kinases. However,
the glucose-driven phosphate flush occurred despite inositol pyrophosphate
depletion. Finally, whilst it is unlikely that XPR1 directly affects
exocytosis, it may protect Ca2+ signaling. Thus we have revealed
XPR1 as the missing mediator of the phosphate flush, shedding light on a
45-year-old mystery.
Large-scale analyses provide no evidence for gene-gene interactions influencing type 2 diabetes risk
Authors: Admin Ada , Nag Abhishek , McCarthy Mark I , Mahajan Anubha
Published: August 2020

A growing number of
genetic loci have been shown to influence individual predisposition to type 2
diabetes (T2D). Despite longstanding interest in understanding whether non-linear
interactions between these risk-variants additionally influence T2D-risk, the
ability to detect significant gene-gene interaction (GGI) effects has to date
been limited. To increase power to detect GGI effects, we combined recent
advances in the fine-mapping of causal T2D-risk variants with the increased sample
size available within UK Biobank (375,736 unrelated European participants, including
16,430 T2D cases). In addition to conventional single variant-based analysis,
we employed a complementary polygenic score-based approach which included
partitioned T2D-risk scores that capture biological processes relevant to T2D
pathophysiology. Nevertheless, we
found no evidence in support of GGI effects influencing T2D-risk. The present
study was powered to detect interactions between common variants with odds
ratios >1.2, so these findings place limits on the contribution of GGIs to
the overall heritability of T2D. 
Literasi Privasi dan Perilaku Proteksi Konsumen Belanja Daring Generasi Y
Authors: Yuniar Ananda Dwitha , Fibrianto Alan Sigit
Published: August 2020

Kondisi yang terbatas dalam proses komunikasi belanja daring memunculkan perdebatan mengenai isu privasi. Beberapa penelitian sebelumnya menyatakan bahwa kekhawatiran konsumen terhadap privasi tidak memiliki konsistensi terhadap perilaku (paradoks privasi). Pengukuran literasi privasi memiliki peran yang cukup penting untuk mengisi gap paradoks privasi tersebut. Pengukuran kausalitas antarvariabel ini menggunakan moderated regression analysis (MRA) dengan pengalaman pelanggaran privasi sebagai variabel moderasi. Total responden yang berpartisipasi berjumlah 283 orang. Temuan penelitian menunjukkan bahwa semakin tinggi tingkat literasi daring pengguna, semakin sadar pula pengguna tersebut terhadap pelanggaran privasi dan memiliki kemampuan bersikap protektif. Namun, pelanggaran privasi tidak bisa dianggap sebagai pemicu tindakan protektif konsumen.
Penggambaran Perempuan di Majalah Popular 1988-2018
Authors: Lase Formas Juitan
Published: August 2020

Artikel ini bertujuan untuk melihat penggambaran perempuan di sampul majalah Popular dari tahun 1988 hingga 2018. Penelitian ini menggunakan konsep pascafeminisme dan metode semiotika. Hasil penelitian menunjukkan bahwa perempuan direpresentasikan dalam dua cara, yaitu objek seksual dan subjek seksual. Objek seksual ditandai melalui tubuh perempuan dengan pose seksual pasif, sedangkan subjek seksual ditandai melalui pose seksual aktif. Penggambaran perempuan sebagai subjek seksual tidak lebih baik daripada objek seksual yang diobjektifikasi. Bentuk-bentuk penggambaran secara provokatif dan seksual aktif dengan pretensi “girl power” sebenarnya adalah eksploitasi.
Komunikasi Partisipatif Panda CLICK! di Bunut Hilir
Authors: Birowo Mario Antonius
Published: August 2020

Sering kali masyarakat di tingkat akar rumput sulit mendapatkan akses ke ruangpublik karena akses yang terbatas bagi partisipasi masyarakat bawah. Komunikasi partisipatifmenempatkan masyarakat sebagai subjek dalam proses komunikasi. Penelitian ini menggunakan metode studi kasus dengan tujuan memahami komunikasi partisipatif dengan menggunakan photovoice yang bernama Panda CLICK!. WWF Kalimantan Barat memberdayakan masyarakat Bunut Hilir, Kabupaten Kapuas Hulu, dengan photovoice. Kabupaten Kapuas Hulu dikenal sebagai wilayah konservasi lingkungan. Photovoice bertujuan agar masyarakat memiliki akses untuk menyatakan gagasan atau pikirannya, khususnya tentang isu lingkungan. Masyarakat difasilitasi kamera saku digital sederhana untuk berekspresi.
Methodologic specificities of developing Russian-speaking students’
monologic skills in Ukrainian
Authors: Lozan Tatyana
Published: August 2020

The article deals with the problems related to the peculiarities of teaching the Ukrainian language to Russian-speaking students under conditions of Pridnestrovie. The relevance of this study is to create a methodology for the development of the Ukrainian monologic speech of Russian-speaking students as a necessary condition for the development and functioning of the official Ukrainian language.
The purpose of the article is to consider the psycholinguistic and methodological aspects of the development of one of the speech competence components – oral monologic speech of Russian-speaking students, to determine the ways, means and methods of developing and improving students’ skills to build monologic statements dedicated to everyday and professional topics. The objectives of the study are as follows: analysis of educational and scientific literature on the problem dealing with the development of the Russian-speaking students’ Ukrainian monologic speech. Taking into account the concretization of the tasks, the study involved a theoretical analysis of scientific and pedagogic literature, which allowed us to find out the modern approaches of scholars to the development of monologic speech within a foreign language environment. These methods were used: analysis, comparison, generalization and systematization of data of educational and scientific literature, pedagogical experience, conceptual provisions of the problem under study, and defining of the main concepts of the study.
The article substantiates the importance of optimal selection and expediency of using General didactic and linguo-didactic principles, methods and techniques for effective developing of oral Ukrainian speech of the first-year students who speak Russian as their mother tongue.
It is determined that the universal didactic and special principles make it possible to build an optimal system of methods and techniques, means and forms of organization and implementation of the task of monologic skills development. It is found out that the effectiveness of improving the students’ monologic speech depends on the appropriate choice and application of various linguo-didactic methods and techniques, their features and classification approaches.
The teaching methods were elaborated based on the principles described in the article which, in its turn, determine the training methods and techniques as well as substantiate the selection of appropriate exercises, tasks, and other means; they constitute the linguo-didactic support for the process related to the developing of Ukrainian oral monologue.
Problems of training sport reserves under conditions
of modern institutions of non-school education
Authors: Todorova Valentyna , Pasichna Tetiana
Published: August 2020

The purpose of the study is to characterize the problems dealing with the training of sport reserves under conditions of sports schools of various types. These materials and methods were used: analysis of literature, standardized interview according to the traditions of social researches which involved questions without any target structure in order to obtain a bigger volume of information from the recipients’ answers. The results are as follows: it was established that the main problem of the development of sports in general and of youth in particular is lack of financial, labour, material and scientific information resources.
Conclusions. The identified problems are interrelated and require a comprehensive, systematic solution. The analysis of the poll results obtained after interviewing practicing coaches who work under conditions of modern establishments of non-school education made it possible to reflect a wider scope of the problems which include the ones as follows: links with general secondary schools have been lost; deficit of skilled personnel; overloading of the groups being trained; lack of material and technical provision as well as of the financial support of the state; out-of-date scientific and methodical provision of sportsmen training, absence of communication with the coaches staff representing the national teams of Ukraine and with the methodology institutions; the work of oversea sport institutions is not organised, etc.
Efecto del muestreo de diferentes hábitats sobre la aplicación de índices bióticos basados en macroinvertebrados
Authors: Leiva Marta , Bonacina Ernestina , Diodato Liliana
Published: August 2020

El objetivo de este estudio fue evaluar el efecto del hábitat en la aplicación de índices bióticos (BI) basados en macroinvertebrados bentónicos. Se muestrearon dos hábitats, (macrófitas y sedimentos), en dos sitios del río Dulce (Cuenca Salí-Dulce, Argentina): S1 (27° 31’ 5.82” S, 64° 52’ 41.37” O) y S2 (27° 28’ 36.21” S, 64°49’ 30.30” O). El muestreo se realizó con caudal bajo, octubre/2015. Se midió pH, conductividad eléctrica (CE µS/cm), temperatura (T °C), sólidos suspendidos totales (SST mg/L), oxígeno disuelto (OD mg/L) y demanda biológica de oxígeno (DBO5 mg/L). Los macroinvertebrados se filtraron con red de nylon de 250 µm y se identificaron al nivel taxonómico requerido para la aplicación de los IB. Se analizaron riqueza taxonómica y diversidad. Se aplicaron tres IB: el IBMWP, el BMWP’ adaptado al río Salí y el IMRP desarrollado para la ecoregión Pampa de Argentina. También se aplicó el ASPT asociado con los BMWP’. Los parámetros físicos y químicos mostraron buena calidad del agua, con un pH promedio de 8,57; CE 773 µS/cm; T 19,5°C; SST 9,27 mg/L; OD 7,49 mg/L y DBO5 3,29 mg/L. Los taxones registrados fueron 34 y la diversidad fue mayor en las macrófitas que en los sedimentos. Los IB mostraron resultados diferentes según el hábitat donde se aplicaron. Las macrófitas contribuyeron con el doble de taxones a los IB, en comparación con los sedimentos. Los valores de ASPT correspondieron a calidad del agua impactada. El IMRP fue el más inclusivo en cantidad de taxones para el cálculo. La conclusión es que el tipo de hábitats influye en la aplicación de los IB.
Hacia una poética de la opacidad. Desde la perspectiva warburguiana de Eduardo Grüner
Authors: Iannone Rocío
Published: August 2020

Iconografías malditas, imágenes desencantadas es un ensayo que propone una reelaboración en la lectura de ciertas imágenes de la cultura, mediante un prototipo warburguiano. Plantea una interpretación desencantada de las imágenes, las cuales revelan un componente siniestro de la realidad en medio de su (no tan) inocente ficción. Eduardo Grüner hace de su ensayo un montaje mediante imágenes muy variadas acudiendo a un abanico de pensadores por dentro y por fuera del campo del arte.
ACOLHIMENTO COM AVALIAÇÃO E CLASSIFICAÇÃO DE RISCO DE UM PRONTO ATENDIMENTO: CARACTERIZAÇÃO DOS ATENDIMENTOS
Authors: JAQUES Luriely Rosa Batista , SILVA Priscila de Oliveira B. da , BORGES Maria Eduarda de O. , PUGLIA Thalis Murilo , MARTINS Carmem Costa , MENDES Elena Carla Batista
Published: August 2020

O presente estudo teve como objetivo caracterizar os atendimentos realizados no Pronto Atendimento de um hospital do interior paulista, segundo o protocolo de acolhimento com avaliação de classificação de risco. Trata-se de uma pesquisa descritiva e quantitativa, baseada em dados secundários, obtidos na Ficha de Atendimento (FA) de uma unidade de Pronto Atendimento (PA). A maior parte dos usuários atendidos no PA é do sexo feminino, com faixa etária de 0-10 e 31-40 anos. O período de maiores atendimentos realizados pelo serviço foi das 18:01-21:00 horas, seguido do horário das 15:01-18:00 horas.  A classificação de risco que mais se evidenciou no presente estudo foram as cores verde e azul. A população tem procurado utilizar o PA como porta de entrada ao serviço de saúde. Isso demonstra que o fluxo entre os níveis de assistência à saúde deve ser melhor estruturado. Os dados podem servir para melhorar o cuidado com qualidade, direcionando-o para as necessidades de saúde da população, uma vez que se conhecem as características dos pacientes atendidos no Pronto Atendimento.

 

ASSESSMENT AND RISK CLASSIFICATION RECEPTION AT A MEDICAL CARE UNIT: SERVICES CATEGORIZATION

 

ABSTRACT

The present study aims at categorizing medical services in an Emergency Room in a hospital at Paulista countryside in line with the reception protocol for assessment and risk classification. It is a case of descriptive and quantitative research based on a secondary database, obtained from Medical Charts (MC) at an Emergency Room (ER). Most of the patients assisted at the ER were female; age ranged from 0-10 and 31-40 years old. Most of the procedures were performed from 6:01 pm. to 9 pm., followed by 3:01 pm. to 6 pm. In the present study, green and blue risk classifications were the most frequent. People have seen the ER as an entry point for health care assistance, evidencing that the flow among assistance levels must have a better organization. Data might be useful to improve quality care, meeting people’s health care needs since the characteristics of the patients who are assisted by Emergency Rooms are known.

 

Descriptors:  Reception. Classification. Emergency Nursing.
Gestión de la Mesa Ambiental dentro del Proceso de Certificación de Cartagena como Destino Sostenible
Authors: Amaris Severiche Angélica
Published: August 2020

Cartagena de Indias ha sido de las ciudades pioneras en la implementación y sostenimiento de la certificación de su centro histórico como destino turístico sostenible bajo la norma NTS TS 001 del Ministerio de Comercio, Industria y Turismo. Este logro ha sido posible gracias a la coalición entre diferentes instituciones públicas y privadas y su compromiso con la ciudad. A través de esta investigación se pretende describir la gestión de las organizaciones que conforman la mesa sectorial ambiental, las actividades, metas e indicadores estipulados y alcanzados a lo largo de estos diez años.
COVID-19 health facility preparedness for protecting healthcare workers: Designing a tool for rapid self- assessment
Authors: Basu Saurav
Published: August 2020

Healthcare workers (HCWs) comprise an irreplaceable resource in combating the COVID-19 pandemic. However, thousands of HCWs have been infected with the coronavirus (SARS-CoV-2) globally, and hundreds have died in the line of duty. Increased stress and fear about personal and familial safety also erode the confidence of HCWs in adhering to the best-practices for COVID-19 patient care. A tool and checklist for rapid assessment of health-care facilities for their preparedness in prioritizing the protection of healthcare workers were developed based on a survey of multiple sources. A total of ten domains were identified that are pivotal toward enabling the protection of HCWs involved in the management of suspected or confirmed COVID-19 patients.
Evaluating the natural growth rate of metastatic cancer to the brain
Authors: Kobets Andrew J. , Backus Reid , Fluss Rose , Lee Alan , Lasala Patrick A.
Published: August 2020

Background:

Brain metastases are becoming increasingly more prevalent as cancer patients survive longer with both improved local and systemic therapy. Little is known, however, of the natural growth rates of brain metastases. This investigation aims to ascertain this growth rate of these lesions before the initiation of any CNS- directed therapy.

Methods:

A total of 700 patients were screened, identifying 18 cancer patients (13 breast and 5 lung) with 29 brain metastases that were serially imaged from 2011 to 2017 before treatment for their intracranial metastases. Growth rates were measured by contouring lesions serially across at least two MRI studies in iPlan software by independent raters. These values were then compared between primary (breast and lung) cancer cohorts.

Results:

The mean age at diagnosis was 53 and 95% were female. The interval between primary cancer diagnosis and brain metastases was 4.6 years and 1.2 years in the breast and lung cancer groups, respectively. Of the breast and lung cancer patients, 23% and 40% were deceased, with respective 5.08 cm3 and 2.44 cm3 initial tumor volumes. The average growth rate of lung and breast tumors was 0.018 and 0.040 cm3/day, respectively, with deceased patients having larger and faster growing tumors. Breast and lung metastases grew 2.39% and 1.14% of their total volumes daily and doubling times were 86 and 139 days, respectively.

Conclusion:

This investigation provides a unique perspective into the biological growth of metastatic brain lesions. It is our hope that this study guides timing of treatment and informs both clinicians and patients of tumor growth kinetics before initiating treatment for intracranial metastases.
Synovial sarcoma of the spine: A case report and review of the literature
Authors: Alshehri Fayez Dhafer , Baeshen Salem Khaled , Samkari Alaa Mohammed Noor , Almehdar Abeer Salim , Lary Ahmed Ibrahim
Published: August 2020

Background:

Synovial sarcoma (SS) of the spine is a rare malignant soft-tissue tumor, and there are few reported cases. The aim of this paper is to report a rare case of spinal SS involving the paraspinal muscles, and to review all such cases reported in the literature.

Case Description:

In this paper, we report a rare case of spinal SS involving the paraspinal muscles in a 12-year-old girl. The patient underwent surgical excision of the mass with adjuvant radiation and chemotherapy. At the 1-year follow-up, there was no evidence of local tumor recurrence, and the patient’s symptoms had improved. In addition, we identified and reviewed 33 reported cases of SS involving the spine.

Conclusion:

Due to the limited number of reported cases in the literature, it is difficult to predict the outcomes of spinal SS. Further, different treatment modalities have been used to treat spinal SS. However, most of the reported cases had poor outcomes. Therefore, prospective multi-center studies are needed to further investigate the treatment strategies and outcomes for patients with spinal SS.
Glioma del nervio óptico en paciente adulto con presentación hemorrágica tratado mediante abordaje endoscópico transesfenoidal extendido
Authors: Rabadán Alejandra T. , Hernández Diego , Varela Analía , Diez Blanca , Rubianes Javier
Published: August 2020

Introducción:

El glioma del nervio óptico es una entidad de muy baja incidencia en pacientes adultos, lo cual impide tener suficiente información sobre historia natural y conducta terapéutica en este grupo etario.

Presentación del Caso:

En el presente artículo comunicamos el caso de un paciente de 27 años de edad con compromiso agudo del nervio óptico izquierdo debido a hemorragia intra tumoral, forma de presentación muy poco común en este tipo de tumores. Se realizó la resección mediante un abordaje endoscópico transesfenoidal extendido, con preservación funcional de la vía óptica contralateral. La anatomía patológica confirmó astrocitoma pilocítico positivo para el rearreglo KIAA 1549-BRAF. y negativo para la mutación BRAF V600E. Teniendo en cuenta la histopatología y biología molecular en este caso, la estabilidad visual contralateral y la resección quirúrgica amplia, se decidió no realizar tratamiento adyuvante con radioterapia o quimioterapia. El objetivo de esta conducta fue evitar lesiones adicionales sobre el quiasma, nervio óptico contralateral y/o hipotálamo.

Conclusión:

Dada la escasa información existente en la literatura médica, el reporte de este caso podría contribuir con información adicional en el manejo y conducta terapéutica de este tipo de lesiones.
The impact of urgent neurosurgery on the survival of cancer patients
Authors: Telles Joao Paulo Mota , Yamaki Vitor Nagai , Yamashita Renata Gobbato , Solla Davi Jorge Fontoura , Paiva Wellingson Silva , Teixeira Manoel Jacobsen , Neville Iuri Santana
Published: August 2020

Background:

Patients with cancer are subject to all neurosurgical procedures of the general population, even if they are not directly caused by the tumor or its metastases. We sought to evaluate the impact of urgent neurosurgery on the survival of patients with cancer.

Methods:

We included patients submitted to neurosurgeries not directly related to their tumors in a cancer center from 2009 to 2018. Primary endpoints were mortality in index hospitalization and overall survival.

Results:

We included 410 patients, 144 went through elective procedures, functional (26.4%) and debridement (73.6%) and 276 urgent neurosurgeries were performed: one hundred and sixty-three ventricular shunts (59%), and 113 intracranial hemorrhages (41%). Median age was 56 (IQR = 24), 142 (51.4%) of patients were metastatic, with 101 (36.6%) having brain metastasis. In 82 (33.7%) of the urgent surgeries, the patient died in the same admission. Urgent surgeries were associated with mortality in index hospitalization (OR 3.45, 95% CI 1.93–6.15), as well as non-primary brain tumors (OR 3.13, 95% CI 1.48–6.61). Median survival after urgent surgeries was 102 days, compared to 245 days in the control group (Log rank, P < 0.01). Lower survival probability was associated with metastasis (HR 1.75, 95%CI 1.15–2.66) and urgent surgeries (HR 1.49, 95% CI 1.18–1.89). Within the urgent surgeries alone, metastasis predicted lower survival probability (HR 1.75, 95% CI 1.15–2.67).

Conclusion:

Conditions that require urgent neurosurgery in patients with cancer have a very poor prognosis. We present concrete data on the magnitude of several factors that need to be taken into account when deciding whether or not to recommend surgery.
Human Neuraminidases Have Reduced Activity Towards Modified Sialic Acids on Glycoproteins
Authors: Hunter Carmanah D. , Porter Elizabeth , Cairo Christopher
Published: August 2020

This work investigated the substrate specificity of hNEU enzymes for a glycoprotein substrate (bovine submaxillary mucin) containing 9-O-acetylated and Neu5Gc residues. Using this model substrate, we observe a general trend for hNEU tolerance of Neu5Ac>Neu5Gc>>>Neu5,9Ac2, consistent with our previous results with glycolipid substrates. These results expand our understanding of hNEU enzyme specificity and suggest that naturally occurring modifications of sialic acids can play a role in regulating hNEU activity.
Knowledge and awareness of COVID 19 on the respiratory system - A survey
Authors: Shabbarish Chockalingam  , Gayatri Devi R  , Yuvaraj Babu K
Published: August 2020

With the world in a lockdown due to the pandemic that is COVID-19, a disease that is similar to the SARS pandemic, it is a highly contagious disease and has a high fatality rate. While the awareness about the presence of such a disease is high, the knowledge about the disease needs assessment. This study aimed to find the awareness of the amount of impact that the disease COVID-19 had on the respiratory system. A survey was conducted with a questionnaire of 15 questions using Google Forms given to a study population of college students aged between 18 and 22 years, the link to which was sent to 106 participants. The data collected was compiled using SPSS software. The compiled data were compared with the results of other studies. There were high similarities in the results of both studies. The research assessed the awareness of COVID-19 and its effect on the respiratory system among college students, and it was found to be high.
Awareness And Myths About Corona Virus: Selected Study On Engineering Students, Guntur, Andhra Pradesh
Authors: Kishore Babu B  , Venkateshwara Kumar K S
Published: August 2020

Coronavirus disease (COVID-19) is a contagious ailment that spreads by a recently exposed coronavirus. A good number of people infected with the COVID-19 virus experienced mild to moderate respiratory illness and got well without requiring exceptional treatment. Aged individuals and those with primary medical troubles like cardiovascular disease, diabetes, chronic respiratory disease, and cancer are more expected to develop an audacious illness. A study was carried out in engineering colleges of Guntur district of Andhra Pradesh. A structured questionnaire was formulated and used to do an online survey of 384 engineering students. The questionnaire included three parts, socio-demographic characteristics, selected myths and beliefs about coronavirus. The data collected were analysed using Microsoft Excel software. About the coronavirus majority of engineering students believed myths are “The study reveals the respondent's opinion on corona as below,40.4% believe that coronavirus will die off when temperatures rise in the spring, 5.1% strongly agree that social distancing guards spreading of coronavirus, 29.4% neither agree nor disagree that Home remedies can cure and protect against COVID-19, 27.9% strongly agree.
Biochemical and functional characterization of a meiosis-specific Pch2/ORC AAA+ assembly
Authors: Villar-Fernández María Ascensión , Cardoso da Silva Richard , Firlej Magdalena , Pan Dongqing , Weir Elisabeth , Sarembe Annika , Raina Vivek B , Bange Tanja , Weir John R , Vader Gerben
Published: August 2020

Pch2 is a meiosis-specific AAA+ protein that controls several important chromosomal processes. We previously demonstrated that Orc1, a subunit of the ORC, functionally interacts with budding yeast Pch2. The ORC (Orc1-6) AAA+ complex loads the AAA+ MCM helicase to origins of replication, but whether and how ORC collaborates with Pch2 remains unclear. Here, we show that a Pch2 hexamer directly associates with ORC during the meiotic G2/prophase. Biochemical analysis suggests that Pch2 uses its non-enzymatic NH2-terminal domain and AAA+ core and likely engages the interface of ORC that also binds to Cdc6, a factor crucial for ORC-MCM binding. Canonical ORC function requires association with origins, but we show here that despite causing efficient removal of Orc1 from origins, nuclear depletion of Orc2 and Orc5 does not trigger Pch2/Orc1-like meiotic phenotypes. This suggests that the function for Orc1/Pch2 in meiosis can be executed without efficient association of ORC with origins of replication. In conclusion, we uncover distinct functionalities for Orc1/ORC that drive the establishment of a non-canonical, meiosis-specific AAA+ assembly with Pch2.
Re-thinking Contextualisation in Solomon Islands school leadership professional learning and development
Authors: Reynolds Martyn , Sanga Kabini , Maebuta Jack , Johansson-Fua Seu'ula
Published: August 2020

This article discusses the perceptions of Solomon Island mentors and regional administrators of a Solomon
Islands aid-funded school leadership professional learning and development intervention. The focus is on
contextualisation, used here as a broad term to refer to the adoption of ways of understanding, thinking and
working recognisable and coherent within local practice. The scope of the article includes the significance of
the configuration of relationships between delivery partners, the power of cause-based motivation, programme
delivery protocols and ways of understanding successful outcomes. Using data drawn from two perspectives in
a multi-facetted programme construction and delivery model, the article offers some provocations regarding
the potential of re-framing relationships and practices in aid-funded development programmes in educational
leadership and beyond.
A tok stori about tok stori. Melanesian relationality in action as research, leadership and scholarship
Authors: Sanga Kabini , Reynolds Martyn , Paulsen Irene , Spratt Rebecca , Maneipuri Maneipuri
Published: August 2020

No description supplied
What if form was the aid? Possible opportunities for renewed neighbourliness in aid relationships
Authors: Sanga Kabini
Published: August 2020

For Pacific Islands' peoples, relationships are of enduring importance. Yet, in spite of decades of aid giving and receiving, relationships in Pacific aid communities have predominantly been indifferent. In an era of global challenges, a new Oceania Education aid community is called to journey together to the common good through relational generosity. This call is based on the premise that people relationships constitute the glue that binds communities. The paper offers for consideration, three opportunities for the Oceania Education aid community to explore.
Corporate insolvency law reform
Authors: Keeper Patricia
Published: August 2020

No description supplied
Ethics curriculum in Indigenous Pacific: a Solomon Islands study
Authors: Sanga Kabini
Published: August 2020

© The Author(s) 2019. A central feature of Indigenous Solomon Islands socialization of family, clan and tribal members is character-shaping. What this looks like, however, has not been researched. This study provides a first look at what is taught as ethics education in Indigenous Solomon Islands. Using data from a wider qualitative study of an Indigenous tribe of Mala’ita Island in the Solomon Islands archipelago, the study is authored and gifted by a Mala’ita Indigenous ethics educator to other Indigenous Pacific and other global educators and researchers. The study findings include: a clearer understanding of Indigenous Mala’ita ethics education including its integrated curriculum, its emphasis on character-shaping and its particular age-gender variations and pedagogies. The study offers pragmatic, conceptual, pedagogical, contextual and research insights for institutional and societal ethics education in Solomon Islands and other Pacific Islands modern states and to others interested in understanding ethics in context.
Positioning Children Citizens: Exploring Discourses in Early Childhood Curricula in China and Aotearoa New Zealand
Authors: Xu Peng
Published: August 2020

Positioning young children as citizens, now rather than as citizens in waiting, is an emerging discourse in early childhood education internationally. Differing discourses related to young children and early childhood reveal various ideas of children as citizens, and what their citizenship status, practice and education can be. This paper analyses the national early childhood education (ECE) curricula of China and Aotearoa New Zealand for the purpose of understanding how children are constructed as citizens within such policy discourses. Discourse analysis is employed in this study as a methodological approach for understanding the subjectivities of young children and exploring the meanings of young children’s citizenship in both countries. Based on Foucault’s theory of governmentality, this paper ultimately argues that young children’s citizenship in contemporary ECE curricula in China and New Zealand is a largely neoliberal construction. However, emerging positionings shape differing possibilities for citizenship education for young children in each of these countries.
Modelo predictivo de conducta de infidelidad sexual entre personas casadas
Authors: Moral-de-la-Rubia José
Published: August 2020

La infidelidad marital es relativamente frecuente, a pesar de sus graves consecuencias. Este estudio tiene como objetivo contrastar un modelo predictivo de infidelidad sexual desde una perspectiva psicosocial. Se colectó una muestra de 790 personas casadas (53.4% mujeres y 47.6% hombres) por rutas al azar en Monterrey, México. Se aplicó la Escala de Valoración de la Relación, Índice de Satisfacción Sexual, Escala de Actitud hacia la Exclusividad Marital, Escalas de conducta infiel, Escala de Búsqueda de Sensaciones Sexuales y Escala de Engrandecimiento Marital. El contraste se hizo por análisis de sendero a través del método de mínimos cuadrados ponderados. Seis de cada 100 participantes están insatisfechos con su matrimonio, 13 de cada 100 están insatisfechos con las relaciones sexuales con su pareja y dos de cada diez ven más defectos que virtudes en sus parejas; asimismo, 83 de cada 100 reportan no incurrir en conductas de infidelidad sexual, 60 de cada 100 muestran total rechazo hacia la propia infidelidad sexual, 72 de cada 100 reportan muy bajo nivel de deseo de infidelidad sexual y 50 de cada 100 muy bajo nivel de búsqueda de sensaciones sexuales. El modelo con dos variables exógenas correlacionadas y cinco endógenas mostró una potencia explicativa muy alta y su ajuste a los datos fue bueno. Se concluye que la variable más crítica en el modelo es el deseo de infidelidad sexual, cuyo determinante más importante es la búsqueda de sensaciones sexuales. Esta variable de rasgo se especificó como una variable exógena, por lo que no es explicada. No obstante, puede ser modulada y modificada, ya que es un rasgo de personalidad. Precisamente, la idealización o el menosprecio hacia la pareja la modulan en el modelo. A su vez, el modelo remarca aspectos de insatisfacción marital y sexual.
The Dimensions of Inclusion in the Context of Cultural and Educational Diversity
Authors: Balint Nela Tatiana , Adam Isabela
Published: August 2020

In this paper I have done the three countries were Romania, Greece, and Turkey. The hypothesis of this research was the presumption that by conducting a comparative study on the three countries, one can assess the level and ways in which the inclusion was done through cultural and educational diversity. The research was directed toward the analysis of the way in which the inclusion was done in regards to the physical, functional, or sensory disabilities, the education level for which this approach is done, and the identification of the implementation means and methods. The conclusion that can be drawn at the end of this analysis can offer good practice models in regards to person - environment - occupation (education), opportunities for the teachers to train and develop professionally in this sense.
SCALED CELL CARCINOMA TYPE VERRUCOUS INFILTRATED – CASE STUDY
Authors: Chan Gómez Xavier Antonio , Nader Jorge Daher , López Alida Bella Vallejo
Published: August 2020

Disorders in patients who develop squamous cell carcinoma can lead to severe conditions. The present case study evidences the advance of this pathology in a patient who goes to the medical services when the problem has advanced.

Objective- To describe the case of a patient who underwent surgery to remove a tumor from the vulvar region to prevent it from triggering in severe states.

Method - Surgery of a vulvar tumor, performed on a female patient of 62 years.

Result- Squamous cell carcinoma, infiltrative verrucous type, with dimensions of 7x6 cm, with an invasion depth of 2.7 mm in the central region   

Conclusion- This type of pathology should not be allowed to worsen when it occurs, as it deteriorates the quality of life of patients over the years. If it is detected and treated early, complications can be avoided. In the present case, the histopathological diagnosis was epidermoid carcinoma. It is expected that the information collected will be useful to professionals and that it contributes as an alert to detect early health problems in patients.
PERCEPTION OF STUDENTS TOWARDS COMPUTER BASED TEST IN AGRICULTURAL SCIENCE TRAININGS AT LADOKE AKINTOLA UNIVERSITY OF TECHNOLOGY (LAUTECH), OGBOMOSO, NIGERIA
Authors: J.O. Akintonde , J.O Akinola , A.A. Alabi , A.O. Tiamiyu , S.A. Gbadamosi , B.S. Bamidele , A.A. Alabi
Published: August 2020

The study examined the perception of agricultural students towards computer based testing (CBT) in Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria. Multistage sampling technique was used to select 108 agricultural students of 200level across all the departments in the Faculty of Agricultural Sciences. However, the respondents have different perception toward CBT as mode of assessment newly introduced by the University management. There is significant relationship between some of the selected personal characteristics the respondents (such as department {(x2=68.481); age (x2=64.389); mode of admission (x2=166.056) and basis for supporting CBT examination (x2=33.333)} and their perception of CBT mode of examination. The study therefore recommends that CBT mode of examination should be encouraged and this innovation should cut across all other level apart from 100 level students. The academic staff members of different department and faculties should encourage the spread of the innovation across the University at large and the university management and department involved in the CBT examination should come together and provide solution to some of the associated constraints with CBT examination in LAUTECH as this would encourage its full adoption and its usage in the various departments and the entire University at large. Keywords: Perception; Agricultural Training; Students; Computer Based Test.
GROWTH OF FINANCIAL DEVELOPMENT IN SUB SAHARAN AFRICAN (SSA) REGION THROUGH MIGRANT REMITTANCES
Authors: Usman Nuruddeen
Published: August 2020

This Paper investigates the impact of remittances on the financial development of countries in the sub-Saharan Africa using panel data analysis from 1985 to 2013. Several Literature has been written on the impact of remittance on growth and on poverty in sub-Saharan Africa however few have critically analysed the impact of remittances on financial development in the region. Using two definitions of financial development, the ratio of money supply to GDP (M2/GDP), and the ratio of domestic credit to GDP (DC/GDP), this paper finds that remittances have a positive effect of financial development. However, the size of the effect depends on definition of financial development that is used in the analysis.
Towards Dynamic Vertical Urbanism
Authors: Hu Rongbo , Pan Wen , Bock Thomas
Published: August 2020

Nowadays a great number of new developments are claimed in the name of “vertical city”, yet few represent this important characteristic. This paper aims to propose a novel vertical city framework, or in other words, dynamic vertical urbanism, featuring constant vertical urban transformation by applying the state-of-the-art construction technologies. First, successful and unsuccessful precedents of building complexes which inspire this novel concept will be analyzed. In addition, building technologies that are crucial for the implementation of this framework will be introduced. As a result, this vertical city concept has the ability to integrate five basic elements of a city: vertical and horizontal circulation systems as its paths, a flexible building envelope as its edges, variable mix-used functional blocks as its districts, sky bridges and roof gardens as its nodes, and the complex itself as a landmark. More importantly, it can change its size, form and function with the help of construction automation technologies, open building principles, and process information modeling. it can also responsively evolve in accordance with social, economic, and environmental shifts in a self-sufficient manner, meanwhile avoiding the risk of being homogeneous with surrounding buildings. Finally, the complex will perform as a series of interconnected components which act together to form a living organism that provides various functions such as corporate, residential, commercial, academic, medical, legal, and infrastructural. In conclusion, this paper will provide researchers, architects and urban designers with a valuable example for the future vertical city developments and beyond.