bluuebunny/crossref_metadata_2025 huggingface dataset:
Recurrent Seizures in a Patient with Primary Hypoparathyroidism
Authors: Kim Hyung-Kyum , Lee Jung-Ju , Kim Byung-Kun , Kang Kyusik , Lee Woong-Woo , Yoo Ilhan , Kim Yong Soo
Published: August 2024

Primary hypoparathyroidism is a rare disorder that presents with various psychiatric and neurological symptoms. A 50-year-old female patient visited hospital due to recurrent seizures. Despite treatment with phenytoin and diazepam, her seizures persisted. Laboratory tests revealed hypocalcemia, hyperphosphatemia, and decreased intact parathyroid hormone level. Following treatment with valproic acid and calcium supplementation, her seizures ceased. Thorough examination including laboratory tests play a crucial role in the accurate diagnosis of primary hypoparathyroidism in a patient with recurrent seizures.
Subdural Empyema Secondary to Sinusitis: Presenting with Cluster-like Headache, Status Epilepticus, and Orbital Apex Syndrome
Authors: No Jinwoo , Kim Jiyoung
Published: August 2024

A 67-year-old man suffered cluster-like headache for 8 months. He underwent endoscopic sinus surgery 2 months prior to the onset of headache. The patient experienced status epilepticus 7 months after the onset of cluster-like headache, and 8 months after its onset, orbital apex syndrome developed. Brain magnetic resonance imaging (MRI) showed subdural empyema. This case emphasizes the association between subdural empyema caused by sinusitis and the potential manifestation of various neurological symptoms, including cluster-like headache, status epilepticus, and orbital apex syndrome.
Dynamics of Phytoplankton in Bangladesh’s Largest Freshwater Lake: Seasonal Shift and Environmental Drivers
Authors: Rabina Akther Lima , Azhar Ali , Md Khaled Rahman , BM Shahinur Rahman , Md Lipon Mia , Ehsanul Karim , Yahia Mahmud
Published: August 2024

This study examines the seasonal shift of the phytoplankton assemblage of Kaptai Lake, Bangladesh, to elucidate the underlying drivers and ecological integrity. In 2020 and 2021, phytoplankton and physiochemical parameters were collected. There were found to be 59 genera of phytoplankton, with the pre-monsoon Zygnematophyceae having the highest seasonal dominance, followed by the monsoon Cyanophyceae and post-monsoon Chlorophyceae. The range of abundance was 0.89-2.95×106 cells/L, respectively. Alpha diversity indices revealed the phytoplankton community was highly diversified. Zygnematophyceae, Dinophyceae, and Bacillariophyceae were identified by SIMPER analysis as major contributors to community variation. Significant correlations were found between temperature, total dissolved solids, alkalinity, conductivity, and transparency, indicating their impact on the dynamics of phytoplankton with seasonal changes. These results demonstrate how the phytoplankton community of Kaptai Lake is rich and dynamic, influenced by seasonal variations in temperature and the resulting changes in the water’s chemistry. This information helps to build successful conservation plans and offers an insightful understanding of the ecology of freshwater lakes.
The Relationship between the Composition of Intestinal Flora and Dementia
Authors: Joanna Michalina Jurek
Published: August 2024

With the aging process of society, the incidence of dementia is increasing year by year and has become a common disease among the elderly which is prognosed to affect approximately 131 million individuals by 2050. The gut microbiome, as a diverse community of microorganisms, plays a crucial role in maintaining health and well-being. Recent research suggests that the gut microbiome significantly influences the development and progression of Alzheimer’s Disease (AD) and other neurodegenerative dementias in the elderly. Interventions targeting the gut microbiome through diet, probiotics, and lifestyle changes may offer promising avenues for preventing these conditions. Aging is associated with specific changes in the gut microbiome composition, including the loss of certain beneficial bacteria at the expense of other potentially pathological microorganisms like Akkermansia and Butyricimonas, which may lead to dysbiosis, which was implicated in various aging-related diseases, including AD. Despite advancements in identifying pathobionts associated with unhealthy aging and disease progression, more research is needed to delineate changes attributable to aging from those due to independent disease processes, nevertheless, some studies suggest that modulating the gut microbiome through diet and probiotic supplementation may have potential in improving health status and reducing rate of neurodegeneration. Especially maintaining a healthy, diverse gut flora through diet and lifestyle may be an important factor in preventing dementia and delaying the progression of aging. Further research is needed to fully elucidate the causal mechanisms linking the gut and brain in neurodegenerative diseases. Therefore, this paper aims to present the latest knowledge on gut microbiota changes and their contribution to dementia, proposing strategies for prevention and delaying neurodegenerative processes.
In situ Hybridization for Tyrosinase v1
Authors: Laguna Ariadna , Vila Miquel
Published: August 2024

In situ hybridization protocol with DIG-labelled riboprobes
SeV standard and copyback genomes PCR Protocols v1
Authors: Lopez Carolina
Published: August 2024

Protocols for the detection of Sendai Virus (SeV) standard and copy-back genomes by PCR
Sonication-induced fragmentation analysis of α-synuclein fibrils v1
Authors: Sokratian Arpine
Published: August 2024

This protocol is designed to quantify the fragmentation pattern of full-length α-synuclein fibrils, induced by ultrasonic frequencies through sonication. To ensure consistency, we have adopted the indirect water-bath sonication method, which offers a more controlled distribution of ultrasonic waves compared to the cup-horn technique. Our protocol involves multiple time-points of sonication, specifically at 1 minute, 2 minutes, 10 minutes, 30 minutes, and 1 hour of sonication. We recommend analyzing the sonication-induced fragmentation of α-synuclein fibrils using dynamic light scattering measurements and acquisition electron micrographs for quantification of fibril length and size distribution
Viyana Kuşatması’nda Viyana’da Türk Algısı – Abraham a Sancta Clara’nın Birlik Çağrısı
Authors: Türk M. Sami
Published: August 2024

Abraham a Sancta Clara adıyla ünlenen Johann Ulrich Megerle 17. yüzyılda Almanca konuşulan coğrafyanın en önde gelen vaizlerindendir. Arkasında bıraktığı yaklaşık 600 kitaplık külliyatıyla da büyük bir yazardır. Ünü kendinden sonraki yüzyıllara sarkmış, Goethe’den Schiller’e ve Heidegger’e kadar uzanmıştır. Türklerin II. Viyana Kuşatması sırasında yazdığı eseri o dönemde Avrupa’nın Türklere bakışını göstermek açısından son derece önemlidir. Bu makale onun Auff, auff, ihr Christen! başlıklı meşhur eserini metin çözümlemesi yöntemi kullanarak ayrıntılarıyla incelemekte, 17. yüzyıl Viyana’sından hareketle nasıl bir Türk ve Müslüman portresi çizildiğini sorgulamaktadır. Çözümlemede Sancta Clara’nın Türkleri barbarlık ve vahşilik ekseninde son derece olumsuz sıfat ve adlandırmalarla nitelediği görülmektedir. Bununla birlikte çözümlenen eseri daha ilginç kılan nokta, olumsuz sıfatların yanında Türklerin meziyetlerini de dile getirmesidir. Yazarın yaşadığı başkenti kuşatan düşman hakkında eserin kayda değer bir kısmını olumlu yönlere ayırması ilginç veriler sunmaktadır.
A Reflective Report to Educational Policymakers: Field Expertise Status of Translation Programs in Turkish State Universities
Authors: Kaş Buğra
Published: August 2024

This qualitative study investigates the educational background and fields of expertise of faculty members in English translation programs at the bachelor's degree level in state universities of Türkiye. Despite the prevalence of these programs across Turkish universities, a discrepancy emerges between the faculty members' doctoral qualifications and the specialized field of Translation Studies. The research aims to reveal the academic landscape of these programs by examining the doctoral disciplines of faculty members, utilizing data primarily sourced from the YÖK (Council of Higher Education) Atlas Database and the YÖK (Council of Higher Education) Academic Database. When information is unavailable in the database above, university websites serve as supplementary data sources. This methodological approach enables a comprehensive analysis of the extent to which academic program qualifications align with the field of Translation Studies. Preliminary findings indicate a significant underrepresentation of faculty with doctoral degrees in Translation Studies, suggesting a potential misalignment between program expertise and the specialized training needs of translation programs. This study underscores the crucial link between the program's field-specific expertise and the quality of training, highlighting the need for policy interventions aimed at bolstering the recruitment and development of academically qualified faculty in the discipline of Translation Studies. The implications of this research extend beyond academia, informing policymakers and educational administrators about the importance of aligning educational offerings with program qualifications to enhance the educational outcomes of translation programs in Türkiye.
The Multifaceted Seafarer: An Explorative Discourse Analysis of Seafarers’ Portrayals in Swedish Maritime Magazines
Authors: Boström Magnus
Published: August 2024

Seafaring is a highly male‐dominated occupation. Within the industry, there is an ambition to increase the proportion of women working in maritime professions. In this endeavor, it is relevant to examine how seafarers are portrayed in various contexts. This study aimed to explore the image of seafarers as presented in Swedish maritime magazines: How are seafarers described, and can these descriptions be seen as performative in shaping a professional identity? To meet this aim, a discourse analysis was performed, based on 20 texts from two maritime magazines, representing both rating and officer seafarers. Overall, six subject positions inhabited by seafarers were identified, with several overlapping characteristics. For example, traits of the traditional seafarer were also found in the masculine seafarer and the flexible seafarer. Furthermore, it is argued that several of the subject positions are difficult to combine with what is referred to as the gender‐equal seafarer, mainly due to challenges in balancing family life with extended periods at sea. The study shows that today’s seafarers, according to how they are depicted in Swedish maritime magazines, have considerable agency in shaping their own professional identity without being forced to conform to a hegemonic masculinity. Finally, it is suggested that the term “seafarer” be used instead of “seaman” in both print and everyday conversations, for increased inclusiveness and representation.
Adequate antiemetic treatment in patients receiving antitumor drug therapy
Authors: Pak M. B. , Zeynalova P.  A. , Mudunov A. M. , Berelavichus S. V. , Tankieva F.  U. , Duguzheva I. A.
Published: August 2024

Despite the widespread use of immuno-oncological and targeted therapy in the treatment of malignant tumors, in real clinical practice the role of chemotherapy is still significant, used both in mono regimen and in combination with other antitumor drugs. Cytostatics cause a wide range of adverse events, which are often the cause of dose reduction, cyclical disorders, or even discontinuation of therapy. One of the most common symptoms is chemotherapy-induced nausea and vomiting which affect not only the quality of life, but also the results of treatment. It is important to address these issues from prevention and treatment perspectives so that patients remain committed to their treatment regimens. Since nausea and vomiting induced by chemotherapy are classified into 5 different types, the main medications for prevention and treatment include 5-hydroxytryptamine type 3 (5-HT3) and neurokinin-1 (NK1) receptor antagonists and corticosteroids. Simultaneous use of drugs from the groups of second-generation NK1 receptor blockers and 5-HT3 receptor blockers, for example: netupitant + palonosetron in combination with corticosteroids, makes it possible to achieve maximum antiemetic effect, even with the most emetogenic antitumor treatment regimens.
Analysis of long-term results of conservative and surgical treatment in patients with locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinuses
Authors: Zhao J. , Mudunov A. M. , Aliyeva S. B. , Kamolova F. Sh. , Stelmakh D. K. , Gelfand I. M.
Published: August 2024

Introduction. Surgical intervention with subsequent chemoradiation therapy is one of the treatment standards in squamous cell carcinoma of the nasal cavity and paranasal sinuses. However, the question of the optimal therapy for this pathology remains open.

Aim. To compare treatment results in patients with locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinuses after conservative and surgical treatment.

Materials and methods. The study included 86 patients with squamous cell carcinoma of the nasal cavity and paranasal sinuses, stages III–Iva, who between 2000 and 2020 received treatment at the N.N. Blokhin National medical Research Oncology Center. Surgical treatment with subsequent radiation or chemoradiation therapy was performed in 31 patients, conservative treatment (radiation or chemoradiation therapy) was performed in 55 patients.

Results. Five-year overall survival in the conservative treatment group was 46.2 %, in the surgical treatment group – 59.7 % (р = 0.081); 5-year progression-free survival was 17 and 50.5 %, respectively (p = 0.002). In patients with Т3N0 tumor who received surgical treatment, 5-year progression-free survival was significantly higher than in patients who received conservative treatment (p <0,05). Comparison of overall survival and progression-free survival of patients who achieved objective response (complete response + partial response) after conservative treatment (n =36) and after surgical treatment (n = 31) did not show statistically significant differences (р = 0.469 and р = 0.183, respectively). The overall 5-year survival rate in the salvage surgery treatment group (24/55) was 63.1 % compared with 59.7 % in the surgical treatment group (n = 31), there were also no significant differences (p = 0.95). In patients with T3 tumor who received conservative treatment in this study, higher risk of progression was observed compared to patients who underwent surgical treatment.

Conclusion. Surgical intervention remains an important treatment method for patients with locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinuses, especially in cases of smaller tumor extent. Conservative therapy seems promising but large-scale prospective controlled randomized clinical trials are necessary to confirm its effectiveness and safety in various patient groups.
Treatment of dirofilariosis in the practice of the head and neck tumor departments (clinical observation)
Authors: Fedina M. S. , Gorchak Yu. Yu. , Titova A. V. , Romanova E. S. , Sadovnikova O. A. , Reshetov D. N. , Ter-Ovanesov M. D.
Published: August 2024

Nowadays, doctors of almost all specializations have to deal with patients who have one or another voluminous formations of the skin and subcutaneous tissue with localization in the head and neck region, which are heterogeneous in their etiology. It’s important to remember that sometimes neoplasms can turn out to be a manifestation of an infectious disease, in particular helminthosis. One of the representatives from this group of diseases is dyrofilariasis, is a zoonotic transmissible tropical helminth disease caused by roundworms – filarias of the genus Dirofilaria, which parasitize in humans mainly in the subcutaneous tissue and lymphatic system. A single filariasis of the Dirofilaria repens type is found in humans in temperate regions of Russia. Generally, dirofilariosis imitates the clinical picture of some other non-parasitic disease. Because of the lack of awareness of this disease among doctors, the process of making a diagnosis is almost always difficult. Often the correct diagnosis is only made during surgical treatment.

The article presents a clinical observation of dirofilariosis with lesions subcutaneous tissue of the dorsum nose.
Clinical and economic assessment of using IRS®19 for the treatment and prevention of acute respiratory infections in children
Authors: Kolbin A. S. , Kasimova A. R.
Published: August 2024

Objective: to perform pharmacoeconomic analysis of the feasibility of using topical bacterial lysate in the form of nasal spray (IRS®19) for the treatment and prevention of upper respiratory tract infections in pediatric population in comparison with other drugs registered in Russia, belonging to the class of topical interferons.

Material and methods. Based on the Rosstat data and information from open sources, the population of patients with acute respiratory infections (ARI) was calculated. Considering the Russian clinical recommendations “Acute respiratory viral infection (ARVI)” and “Acute tonsillitis and pharyngitis (acute tonsillopharyngitis)”, the direct medical costs of providing medical care to specialized patients were determined. Direct costs on the part of parents included all costs for purchasing medicines for basic or concomitant therapy. Direct costs on the part of the healthcare system and the state included the costs of providing medical care at the outpatient stage. Direct non-medical costs included payments for disability leaves, indirect costs – lost gross domestic product (GDP) due to absence from work.

Results. The total costs of the healthcare system and the state for 1 AVI patient are 42,472 rubles in case of uncomplicated course and 70,649 rubles in case of complicated course. In case of IRS®19 application from the first day of the disease, it is possible to reduce its duration by more than two-fold. Thus, the costs of medical care amount to 2,078 rubles. Payments for disability leaves by the Social Fund of Russia will amount to 2,287 rubles, and the lost GDP – 9,148 rubles (total costs 13,513 rubles).

Conclusion. For the first time in Russian economic conditions, the use of IRS®19 for ARI treatment and prevention in children was evaluated. IRS®19 application from the first symptoms of the disease allows refusing the use of topical interferons, reduces the duration of symptoms and the need for prescription of antitussives, vasoconstrictors, and antibiotics.
Approaches to determining the cost of laboratory tests
Authors: Khayrullin I. I. , Omelyanovskiy V. V. , Gostishchev R. V. , Sukhorukikh O. A. , Kovaleva S. A. , Gorodetsky B. G.
Published: August 2024

Background. Determining the cost of laboratory tests is a significant factor in the context of economic analysis and management of clinical diagnostic laboratories. Information about costs allows medical organizations to plan operational activities more efficiently, optimize resource utilization, and exercise control over expenditures. These measures are aimed at improving the financial position and enhancing the operational efficiency of the laboratories.

Objective: to review various methods for calculating the cost of laboratory tests.

Material and methods. The study included the collection and analysis of publications on calculating cost of laboratory tests, determining their prime cost in PubMed/MEDLINE and Google Scholar databases, as well as in Google and Yandex search engines for similar “cost laboratory test” query. The regulatory documents of the Russian Federation in this area were considered.

Results. For calculating the prime cost of laboratory tests such methods as direct costing, regulatory prime costing, total prime costing, activity-based costing (ABC), standard costing, costing for base service, department costing, cost-volume analysis are used. The ABC and standard cost methods provide the most accurate assessment of the impact of various factors.

Conclusion. The approaches established by regulatory documents do not contradict each other and represent the implementation of total costing method. At the same time, a medical organization may use other methods for calculating the cost of laboratory tests, depending on the objectives of the analysis, the specifics of the laboratory and the cost accounting method adopted in accounting policy, the management accounting system.
Cystatin C: diagnostic and prognostic value in acute kidney injury
Authors: Korabelnikov D. I. , Magomedaliev M. O.
Published: August 2024

Acute kidney injury (AKI) is a life-threatening condition that occupies one of the leading places in the structure of mortality in intensive care units. AKI markers common in clinical practice are characterized by a number of disadvantages: serum creatinine – late response to damage to the kidney tubules, an increase in damage to more than 50% of nephrons; urine volume – limited diagnostic value and overdiagnosis of AKI in dehydration, the impossibility of assessing on the basis of a single measurement, as well as the need for regular and frequent dynamic monitoring. The review considers the diagnostic and prognostic possibilities of cystatin C (CysC) in AKI. The results of 55 researches were analyzed. The influence of a number of physiological conditions and non-renal diseases on blood serum and urinary CysC levels were shown. These indicators proved to be highly sensitive and specific biomarkers for AKI diagnosis and prognosis, allowing the specialists to verify renal dysfunction at an early stage of development, ahead of structural changes, and thereby to timely correct treatment, including withdrawal of nephrotoxic drugs and initiation of nephroprotection therapy.
Collagens of placenta composition in obese puerperant women who gave birth to сhildren at St. Petersburg State Pediatric Medical University in 2018–2021
Authors: Petrenko Yuriy V. , Ivanov Dmitry O. , Polyakova Victoria O. , Novikova Valeria P. , Fedotova Elena P. , Demchenkova Olga A. , Levadneva Marina I. , Tarkhanova Elena B.
Published: August 2024

BACKGROUND: The relevance of the problem of obesity is associated with the high frequency and steady growth of this pathology in the population. The epigenetic influence of maternal obesity on the course of pregnancy and childbirth, as well as on the condition of the fetus and newborn, is currently being studied. This article analyzes changes in the composition of the connective tissue of the placenta against the background of obesity in pregnant and puerperas.
AIM: The aim of this study is to identify the pathomorphological features of the placenta and the composition of placental collagens in women who were obese before pregnancy and at the time of delivery at the Perinatal Center of St. Petersburg State Medical University from 2018 to 2021 to assess potential fetal risks and to predict possible complications during pregnancy and in the postnatal period for the mother.
MATERIALS AND METHODS: A histological examination of the placentas of obese women (18 patients) and the ones with a normal body mass index (18 patients) who gave birth to mature newborns at the Perinatal Center of St. Petersburg State Medical University from 2018 to 2021 was performed followed by immunohistochemical examination. Staining of placenta specimens was carried out in accordance with the standard immunohistochemical protocol, using primary antibodies to type I–IV collagen.
RESULTS: Microscopic examination of chorionic villi revealed no significant differences in the presence of chronic inflammation and angiogenesis disorders between the groups. When studying collagen expression levels, the following differences have been found: in the group of pregnant obese patients, the optical luminescence density and distribution area for type I–III collagen in the placenta were significantly higher, while for type IV collagen they were significantly lower compared with the control group.
CONCLUSIONS: The following features of the formation of connective tissue in the placenta in obese mothers have been revealed: an increase in type I–III collagen production and a decrease in type IV collagen production. The obtained findings indicate an earlier functional and morphological change in the placenta than those detected by standard histological methods.
Influence of non-alcoholic fatty liver disease on reproductive function in an experiment
Authors: Brus Tatiana V. , Kalinina Anna A. , Bannova Anastasia A. , Korablev Rodion V. , Brus Yurii S.
Published: August 2024

BACKGROUND: Currently, the attention of specialists is drawn to the relationship between non-alcoholic fatty liver disease and the development of reproductive disorders in both men and women. To better understand the etiology of these conditions and the mechanisms of pathogenesis, experimental models are being developed. A model using a hypercaloric diet containing increased amounts of carbohydrates is presented in this study.
AIM: The aim of this study is to study the effect of non-alcoholic fatty liver disease on the reproductive function of female Wistar rats.
MATERIALS AND METHODS: The study was conducted on 30 female Wistar rats, which were divided into two groups. The rats in the control group received standard nutrition. The non-alcoholic fatty liver disease model was reproduced in rats of the experimental group. To verify the diagnosis in the groups, changes in animal body weight, total cholesterol, triglycerides and glucose were assessed. After the diagnosis of non-alcoholic fatty liver disease was established, males were placed with the females to assess the females’ fertility.
RESULTS: Keeping animals on a high-carbohydrate diet led to obesity in the females of the experimental group. In rats with non-alcoholic fatty liver disease, a significant increase in the blood levels of total cholesterol and triglycerides, as well as glucose, was found. A significant decrease in the number of pregnancies was recorded in the group with non-alcoholic fatty liver disease. A decrease in the number of individuals in the offspring was also revealed.
CONCLUSIONS: The results of the experiment indicate that the use of a hypercaloric diet in rats causes the development of non-alcoholic fatty liver disease. Non-alcoholic fatty liver disease significantly reduces the fertility of female laboratory rats and reduces the number of individuals in the litter. This model can be used to study the causes of the development of the disease, as well as to better understand the mechanisms underlying reproductive dysfunction in patients.
Ethical aspects of gene editing in biology and medicine
Authors: Mettini Emiliano , Wiegel Narine L.
Published: August 2024

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Mentoring in the healthcare system: problems and prospects
Authors: Gareeva Irina A. , Litvintseva Svetlana A.
Published: August 2024

BACKGROUND: During the rapid development of science and medical technologies, the professional environment faces the urgent task of finding mechanisms to increase the professional competencies and practical skills of medical specialists in the process of professional socialization. The sociological study conducted by the authors focused on identifying factors of successful/unsuccessful professional socialization of young medical specialists, including mentoring.
AIM: Determining the role of the mentoring institution as a factor influencing the success/failure of professional socialization of medical specialists.
METHODS: A survey was conducted among clinical residents of the Far Eastern State Medical University. A total of 184 respondents were interviewed using a Google form questionnaire. Methods of analysis, comparison, generalization of obtained data, analysis of regulatory documents, survey results, and secondary data from sociological research were used. Descriptive statistics methods provided by SPSS and EXCEL software were used at the level of data processing and work with source material.
RESULTS: The sociological study identified the most pressing problems of introducing and implementing mentoring practices in the healthcare system. It also determined the role of the mentoring institution as a socializing factor influencing the success/failure of professional socialization of medical specialists. The study formulates tasks for further research into the process of professional socialization of medical specialists, focusing on identifying positive and destructive factors and the role of socialization institutions.
CONCLUSION: Problems in implementing mentoring practices in healthcare relate to the low mentoring activity of practicing medical specialists. A special need for mentoring practices was identified at the stage of postgraduate training (clinical residency) by 83% of respondents and at the stage of starting independent professional work by 61% of respondents. Respondents expressed a positive attitude towards mentoring in healthcare: 90% indicated that having a mentor when obtaining a medical specialty is mandatory.
Inflammatory Biomarkers in Patients With Type 2 Diabetes Mellitus and Heart Failure With Preserved Ejection Faction
Authors: Sveklina T. S. , Shustov S. B. , Kolyubaeva S. N. , Kuchmin A. N. , Kozlov V. A. , Oktysyuk P. D. , Konyaev V. V.
Published: August 2024

Aim. To verify the relationship between gene polymorphisms of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) with inflammation markers and codependent metabolic variables in patients with type 2 diabetes mellitus and chronic heart failure (CHF).

Material and methods. This study included 154 patients (mean age, 69.1±3.2 years). The control group consisted of 47 patients with metabolic syndrome (MS) without CHF; the 2nd group included 56 patients with CHF with preserved ejection fraction (CHFpEF); and the 3rd group consisted of 51 patients with CHF with reduced ejection fraction (CHFrEF). The rs1800629 polymorphism of the TNF-α gene (TNF-α: G308A) was studied in real time by the polymerase chain reaction (PCR) method and the rs1800795 polymorphism of the IL-6 gene (IL-6: 174 G>C) was studied by PCR with the electrophoretic detection. The frequencies of polymorphic alleles were compared with the clinical blood test results, plasma concentrations of C-reactive protein (CRP), TNF-α, leptin, and fibrinogen. Differences between the groups were determined using the F test. Relationships between individual studied parameters were identified using the regression analysis.

Results. In most patients, the occurrence of gene polymorphisms was eident as increased plasma concentrations of biomarkers. An association was found between the TNF-α gene polymorphism (G308A) and an increase in plasma TNF-α and between the IL-6 gene polymorphism (174 C>G) and an increase in plasma CRP. In the CHFpEF group, the rs1800629 gene polymorphism was observed in 55% of patients, among whom 93% had increased TNF-α. The rs1800795 gene polymorphism was observed in 82% of CHFpEF patients, among whom 21% had increased CRP. In the CHFrEF group, the G308A transition in the TNF-α gene was observed in 53% of patients; an increase in the respective cytokine was noted in 67% of patients; the IL-6 gene polymorphism 174 C>G was found in 78%, however, only 14% of patients with this polymorphism had also increased CRP. In the control group, the TNF-α G308A gene polymorphism was found in 30% of patients, while an increase in free TNF-α was associated with this polymorphism in 50% of patients; the IL-6 174 C>G gene polymorphism was detected in 78%, while no increase in the CRP level was observed in this group. This demonstrates a high probability of the TNF-α G308A gene polymorphism occurrence in patients with CHF.

Conclusion. Inflammatory markers are important predictors of CHF. The most significant predictor was the TNF-α G308A gene polymorphism, which was observed in more than 50% of patients, the majority of whom had an increase in plasma TNF-α
Factors that Determined a Positive Response to Resynchronization Therapy in Patients With Chronic Heart Failure and Cardiac Dyssynchrony. One Center Experience
Authors: Postol A. S. , Neminushchiy N. M. , Antipov G. N. , Ivanchenko A. V. , Lyashenko V. V. , Kalinin D. A. , Kotov S. N. , Vygovsky A. B. , Shneider Yu. A.
Published: August 2024

Aim. To evaluate the efficacy of cardiac resynchronization therapy (CRT) in patients with chronic heart failure (CHF) associated with cardiac dyssynchrony and to identify the factors that influence the CRT efficacy.

Material and methods. This retrospective study included 155 patients after implantation of CRT devices. The CRT devices with a built-in cardioverter-defibrillator (CRT-D) and without it (CRT-P) were implanted in 139 (89.7%) and 16 (10.3%) patients, respectively. The follow-up period was 52.37±35.94 months. Based on the study results, two groups of patients were formed depending on the presence of a clinical response to CRT, responders and non-responders. The factors that influenced the clinical response to CRT were studied. The effect of the baseline state of patients on the effect of therapy was assessed. The need for CRT optimization and a possibility of using electrocardiographic criteria for that purpose were studied. Modern devices and leads for CRT, their functional capabilities and their influence on the CRT efficacy were characterized. Statistical analysis was performed with an IBM SPSS Statistics 21.0 (Chicago, USA) package.

Results. CRT implantation with the left ventricular lead placement according to the traditional technique, through the coronary sinus, was successful in 130 (87.9%) patients. Difficulties with the left ventricular lead placement were noted in 13 (8.3%) patients when other techniques were used. After 6 months, a hemodynamic and clinical response was observed in 112 (72.2%) patients, and no positive response in 43 (27.8%). The increase in left ventricular ejection fraction in the responder group was more than 21.8±3.7%, which was associated with an improvement of the 6-minute walk test results. Th clinical response was significantly influenced by the possibility of stimulation from the basal parts of the heart; the use of more modern devices for CRT and quadripolar left ventricular leads; timely CRT optimization; and persistent dyssynchrony in non-responders. During the follow-up period, 34 (21.9%) patients died. The death rate in the non-responder group was significantly higher than in the responder group, 18 (41.3%) vs. 16 (14.3%), p=0.001. The main cause of death in the group of non-responders was CHF. Heart transplantation was performed in 3 (1.9%) patients.

Conclusion. CRT increases the life span and improves the quality of life in patients with CHF and cardiac dyssynchrony. There was a group of patients with no benefit from CRT in this study. Modern devices allow increasing the number of patients who benefit from CRT. Periodic optimization of CRT is necessary. When optimizing CRT, it is possible to use electrocardiographic criteria of effectiveness: duration of the QRS complex and changes in the position of the electrical axis of the heart.
Enhancing Loyalty in the Indonesian Post: Unraveling the Influence of Relational Benefits and Relationship Quality
Authors: Napitupulu Samuel Mario Arnoldi , Alversia Yeshika
Published: August 2024

The advancement of technology has led to the proliferation of e-commerce services, resulting in an increased demand for courier services in Indonesia. Pos Indonesia, a pioneer in courier services, now faces competition from industry players such as JNE, JT, SiCepat, and others, who employ strategies focused on providing relational benefits. These benefits include special discount facilities, free item pick-up, and establishing social relationships and trust through integrated technology. However, contrary to previous research findings, these built-in benefits do not necessarily contribute significantly to customer loyalty. This study examines the role of relational benefits, with relationship quality as a mediating variable, in enhancing customer loyalty within the context of Pos Indonesia's efforts to retain loyal customers through various innovations. The study used a quantitative method to sample 205 respondents who have used Pos Indonesia's services in the last 6 months. The PLS-SEM method was used to analyze the data. The study reveals that repurchase intention increases with high levels of trust and satisfaction, supporting the confidence and social benefits that have been built. Surprisingly, unique treatment benefits do not influence consumer loyalty behavior.
WHO/INRUD Drug Prescribing Indicators in the Emergency Ward of a Teaching Hospital, South East of Iran
Authors: Moradi Mandana , Rafighdoust Alireza , Hamedi-Shahraki Soudabeh
Published: August 2024

Background: Rational drug use is an important issue in all healthcare settings. Core drug use indicators have been developed by World Health Organization/ International Network for Rational Use of Drugs (WHO/INRUD). The prescribing indicators measure healthcare providers’ performance in five key areas of drug usage. The aim of this study was to evaluate WHO/INRUD indicators of prescribing in emergency ward of a teaching hospital.
Methods: This descriptive cross-sectional study was carried out in Emergency Ward of teaching hospital from March 2022 – March 2023. A standard prescribing indicators form was utilized to collect the required data using WHO drug prescribing indicators. Besides the rate of intravenous fluids and narcotic analgesics administration was evaluated. Index of rational drug prescribing (IRDP) was also calculated for each month and the mean of 12 IRDPs represent the emergency ward IRDP. Descriptive statistics were used for analysis.
Results: Antibiotics were prescribed in 34% of studied prescriptions and ceftriaxone was the most widely used antibiotic (33.8%). Index of rational drug prescribing (IRDP) was 0.73 for polypharmacy, 0.93 for generic name prescribing, 0.88 for antibiotic prescribing, 0.1 for injectable drug use and 1 for formulary-based drug prescription. Total IRDP for the emergency ward was 3.64 (from optimal value of 5). IV fluids and narcotics were prescribed in 61.1% and 8.3% of studied prescription respectively.
Conclusion: We concluded that although our overall IRDP value is below the WHO standard but it is about other neighbor countries. Our condition regarding IV drug administration showed a huge difference with WHO standards. It shows we need more input and regulations in this regard.
Safe provision of nursing care as predicted by nursing students: A cross-sectional study
Authors: Solgajová Andrea , Kohanová Dominika , Zrubcová Dana , Pavelová Ľuboslava
Published: August 2024

Background & Aim: Assessment of safety culture and nursing students’ competencies in patient safety is essential for readiness to provide quality and safe care. The objectives of the study are to examine how nursing students perceive patient safety culture and to evaluate factors that may influence their perceptions.
Methods & Materials: A descriptive cross-sectional study was conducted using the Slovak version of the Hospital Survey on Patient Safety Culture for Nursing Students and the Questionnaire for Measuring Demographic Variables and Information on the Education Process. The study involved 242 nursing students from two faculties in Slovakia. Data were analyzed using descriptive and inferential statistics.
Results: None of the dimensions of patient safety culture was rated by the nursing students above the necessary level of 75 %. Statistically significant correlations and differences were found between the nursing students’ perceptions of patient safety culture and some selected sociodemographic variables. Multiple regression analysis revealed significant associations between the nursing students’ perceptions of patient safety culture and overall patient safety grade, the number of reported events in the workplace, and the number of reported events by nursing students.
Conclusion: Recognising nursing students’ perceptions of patient safety culture enables identification of weaknesses, and early implementation of targeted interventions and educational initiatives to increase overall patient safety in care provision. Future research should focus on recognizing relationships between perceived patient safety culture, teamwork, education, and indicators of safe and quality care during clinical training from nursing students’ perspective.
Exclusive breastfeeding experience among healthcare working mothers in central Tanzania: A qualitative study
Authors: Eliufoo Elihuruma , Mgeyekwa Shedrack , Majengo Victoria , Yusheng Tian , Yamin Li
Published: August 2024

Background & Aim: Exclusive breastfeeding (EBF) is essential for infant health, yet the global prevalence is below target. Tanzania is facing challenges in promoting EBF due to sociocultural and economic factors. Despite efforts, rates remained low, especially among working mothers. The experience of healthcare-working mothers in EBF is underexplored despite facing unique challenges like irregular schedules and workplace stressors. This study aims to explore healthcare-working women's experiences with EBF.
Methods & Materials: This qualitative study involves fifteen participants from two referral hospitals in Tanzania. We employed semi-structured interviews to explore the significance of their lived experiences while keeping the interview on track. We sampled our participants using purposive and snowball sampling. The interviews were recorded using a digital audio recorder and transcribed verbatim. Then, thematic analysis was used to analyze data.
Results: Participants shared insights into their EBF practices, highlighting the significance of breastfeeding knowledge and its benefits for mothers and children. Key themes identified were healthcare-working mothers' knowledge and practice of EBF, balancing EBF and work, and barriers to EBF while working. Mothers emphasized EBF's health and emotional benefits, noting strategies to ensure sufficient milk supply and challenges in maintaining EBF due to work demands, fatigue, and physiological discomforts. Support systems at home and workplace policies were crucial for facilitating EBF, yet the availability of alternative milk sometimes hindered sustained EBF.
Conclusion: This research provides valuable insights into the experiences of healthcare-working mothers in EBF. The findings underscore the importance of promoting supportive environments, workplace policies, and social networks to facilitate exclusive breastfeeding continuation for working mothers.
The effect of education through a mobile application on self-care behavior in patients undergoing percutaneous coronary: A randomized clinical trial
Authors: Salavati Khatereh , Rejeh Nahid , Rohani Farhad , Nayeri Alireza Dehghan
Published: August 2024

Background & Aim: Patients who receive percutaneous coronary interventions often display inadequate levels of self-care actions, which could create difficulties in managing the disease and achieving favorable treatment results. This study investigates the impact of using an educational mobile application on self-care behaviors in patients undergoing percutaneous coronary intervention.
Methods & Materials:  A randomized clinical trial was conducted with 110 patients undergoing percutaneous coronary interventions at Shahid Rajaei Hospital in Karaj, Iran, in 2023. The study enrolled and assigned them to either the intervention group (n=55) or the control group (n=55) by block randomization. In addition to training upon discharge, the experimental group received educational resources via a mobile phone application. The data collection instruments included MSCBS. Patients completed the MSCBS before the intervention and 4 weeks later. The data were analyzed with SPSS 21. The study's level of significance was set to P<0.05.
Results: Before the intervention, there was no significant difference in the self-care scores and the subscales between the two groups (P<0.05). Nonetheless, After the intervention, a significant difference was observed in the self-care scores and the subscales between the control and intervention groups, (p=0.001), and the difference in scores between the control and intervention groups increased significantly after the intervention and the scores of the intervention group had a significant increase compared to the scores of the control group.
Conclusion: The study showed that the mobile phone educational application could improve self-care behaviors in patients undergoing percutaneous coronary interventions. Therefore, it can be recommended that nurses working in medical centers use this educational application to enhance self-care in these patients.
Big five personality traits and resilience as predictors for self-isolation adherence during COVID-19 pandemic
Authors: Alimoradi Kayvan , Gheshlagh Reza Ghanei , Albatineh Ahmed Najeeb , Nikkhoo Bahram , Nargesi Farideh , Rahmani Khaled
Published: August 2024

Background & Aim: Results of previous studies on the role of personality traits and resilience in explaining health-oriented behaviors such as social/physical distance and self-isolation were inconsistent. The present study was conducted to determine the role of the five big personality traits and resilience in adherence to self-isolation during the COVID-19 pandemic.
Methods & Materials: A prospective longitudinal cohort study tracked 112 healthcare providers who tested positive for SARS-CoV-2. Using GPS data from their cell phones, researchers assessed self-isolation adherence over 14 days. Participants completed NEO-Five-Factor Inventory (NEO-FFI) and Connor–Davidson Resilience Scale (CD-RISC) questionnaires.
Results: Sixty-one (58.7%) of the subjects violated their self-isolation, and 43 (41.3%) did not violate it during the 14 days after PCR positivity for COVID-19. After adjustment for potential confounders, results showed that only two of the five big personality traits included, conscientiousness (AOR=1.37; 95%CI: 1.15–1.63) and neuroticism (AOR=0.85; 95%CI: 0.74–0.98), were significantly related to the self-isolation adherence. This means a one-unit increase in conscientiousness is associated with 37% higher odds of self-isolation adherence, while a one-unit increase in neuroticism reduces self-isolation adherence by 15%.  Resilience was the main predictor for self-isolation adherence in which a one-unit increase in resilience score, the odds of adherence to self-isolation significantly increased by 18% (AOR=1.18, 95%CI: 1.07–1.30) (P<0.001).
Conclusion: The study suggests that fostering conscientiousness and resilience among individuals may enhance self-isolation commitment during pandemics. Further research is needed to explore the influence of agreeableness, extraversion, and openness to experience on self-isolation adherence.