bluuebunny/crossref_metadata_2025 huggingface dataset:
Good Suggestion - But No! Innovation as the Struggle Between Different Roles and Perceptions in a Municipal Organisation
Authors: Isaksen Kjersti
Published: February 2024

Collaboration has been increasingly recognised as a key for enhancing capacity, effectiveness, and spurring innovation in the public sector. The purpose of this paper is to study empirically how different perceptions and roles within an organisation handle a proposal from strategic management related to engaging a large municipality in collaboration with social entrepreneurs. The primary focus of attention is middle managers, as they stand out as a central counterpart to the administrative and political leadership. The data collection included in-depth interviews, observation and documents. An abductive analysis that combined empirical findings with theoretical insights showed that middle managers controlled positional and professional power bases, enabling them to block the formal lines of authority. The paper contributes to view innovation as a part of the struggle between different roles and perceptions within an organisation and to an explanation for the outcome resulting from different power bases.
Seeding Density and Foliar Application of a Calcium and Potassium-Based Organomineral Fertilizer in Oat Crops
Authors: Coppetti Karin , Da Silva José Antonio Gonzalez , Carvalho Ivan Ricardo , Magano Deivid Araújo , Panozzo Luís Eduardo , Da Rosa Juliana Aozane , Peter Cibele Luisa , Diel Pedro , Schünemann Lara Laís
Published: February 2024

Purpose: To present the benefits of increasing oat sowing density on productivity, uniformity, soil quality and reduction of pesticides and the use of an organomineral product based on calcium and potassium as an alternative to lodging control, promoting more sustainable cultivation systems.
 
Theoretical framework: Increasing plant density can promote productivity, rapid soil coverage, reduction of weeds and greater harvest uniformity, reducing the use of pesticides. However, increasing seeding density can promote lodging. Lodging is the phenomenon in which plants leave the vertical position and fall to the ground, affecting the quality of the grains. The commercial product registered to control lodging is highly toxic to the environment. Organomineral sources with potassium and calcium represent an alternative for controlling lodging with reduced environmental impacts.
 
Results: Benefits of increased seeding density to promote grain yield have been found for several crop species, reinforcing the need for adapting seeding density for oat crops. The use trinexapac-ethyl as a growth regulator, it poses risks of phytotoxicity and environmental contamination. In this context, several studies have indicated that potassium and calcium favor cell wall rigidity, potentially contributing to oat stem strength.
 
Originality/value: This study provides significant contribution to the advancement of research on oat in Brazil, bringing new information benefiting farmers, technical assistance agents, and the food industry and improving the production system to ensure food security and care for the environment.
PERANCANGAN ALAT ANGKUT KASUR DENGAN MENGGUNAKAN METODE REVERSE ENGINEERING DAN VDI 2221 (STUDI KASUS: PT. XYZ)
Authors: Gosal Marchelino , Daywin Frans Jusuf , Adianto
Published: February 2024

Pada saat ini penanganan material di industri masih ada yang dilakukan secara manual yang dapat diartikan sebagai tugas pemindahaan barang, aliran material, produk akhir atau benda- benda lain yang menggunakan manusia sebagai sumber tenaga. Pada PT. XYZ kegiatan yang berhubungan dengan pengankatan dan juga pemindahan barang yang dilakukan adalah pemindahan springbed secara manual tetapi pekerja merasa kesulitan dan juga adanya beberpa keluhan serta nyeri pada bagian tubuh berdasarkan kuesioner Nordic Body Map yang diberikan kepada pekerja. Oleh karena itu penulis membuat suatu rancangan alat angkut springbed untuk memindahkan kasur dari lantai produksi ke gudang yang sesuai dengan prinsip-prinsip ergonomic operator dengan menggunakan metode Reverse Engineering untuk mengembangkan produk yang berfungsi untuk meningkatkan kinerja para pekerja dan sebuah alat angkut tersebut. Dan juga menggunakan metode VDI 2221 untuk mengoptimalkan teknoligi, material, dan keadaan ekonomi alat angkut tersebut. Hasil Analisa REBA kedua pekerjaan yang dilakukan pekerja memiliki tingkat resiko tinggi dengan skor REBA 8 untuk pengangkatan dan tingkat resiko sangat tinggi dengan skor REBA 12 untuk peletakan Setelah melakukan perhitungan REBA didapati nilai dari RWL = 7,5071 Kg dan nilai Lifting Index (LI) sebesar 4,662. Nilai Lifting Index (LI) yang didapatkan >1 sehingga memiliki resiko cidera pada operator.
PERANCANGAN AKSESORIS MOTOR UNTUK MENINGKATKAN KEAMANAN BERKENDARA
Authors: Cherry  , Widodo Lamto , Gozali Lina
Published: February 2024

Lampu tanda belok atau lampu sein ini berguna sebagai penanda saat ingin berbelok ke kanan dan kiri ketika berada di tingkungan, pertigaan, hingga perempatan. Dengan menyalakan salah satu sisi lampu, yakni kanan atau kiri, maka memberi informasi kepada pengendara di belakang dan di depan bahwa sedang ingin berbelok. Beberapa faktor dapat menyebabkan pengendara lupa mematikan lampu sein, seperti kurang konsentrasi ataupun warna lampu sein pada siang hari yang kurang terlihat. Lampu Sein yang terus menyala dapat membingungkan pengendara lain. Kebingungan pengendara lain dapat memecah konsentrasi pengguna jalan dan menimbulkan kecelakaan lalu lintas. Dengan tujuan untuk meneliti penyebab lampu sein yang terus menyala dan membingunkan orang lain maka dilakukan penyebaran kuisioner untuk para pengendara motor. Metode penelitian yang digunakan adalah AHP dengan menyebarkan kuisioner kepada para pengendara motor dan hasilnya adalah perancangan ‘Smart Light Spion’ untuk pengembangan aksesoris motor.
ANALISIS RISIKO KESELAMATAN DAN KESEHATAN KERJA DENGAN METODE HAZARD DAN OPERABILITY (HAZOP) PADA CV. XYZ
Authors: Sebayang Albert Ericson , Sukania I Wayan , Adianto
Published: February 2024

CV. XYZ sendiri memiliki beberapa standar untuk kesehatan dan keselamatan kerja yang diterapkan pada perusahaannya. Standar yang diterapkan kepada para pekerjanya adalah pemakaian Alat Pelindung Diri atau APD (Sarung Tangan, Sepatu dan Masker, Pelindung Mata, Pelndung Kaki, Pelindung Telinga), penanganan terhadap kecelakaan kerja, penanganan terhadap keadaan darurat, penanganan terhadap kecelakaan kerja serta larangan merokok dan membawa alat berbahaya dalam area pabrik. Metode yang digunakan untuk menilai seberapa besar tingkat keparahan kecelakaan kerja yang terjadi pada CV. XYZ adalah metode HAZOP dengan menggunakan indikator likelihood dan severity kemudian dihitung dengan matriks resiko lalu diklasifikasikan didalam Hazop Worksheet. Hasil yang didapat dari analisis cenderung merupakan kecelakaan jenis ringan hingga sedang yang disebabkan karena pekerja ceroboh dan kurangnya rambu yang tertera didalam pabrik sehingga pekerja sering lupa untuk mengenakan alat pelindung diri yang sudah ditetapkan sesuai standar pabrik. Beberapa solusi untuk mengurangi kecelakaan kerja pada CV. XYZ diantaranya adalah melakukan penataan peralatan produksi, melakukan pengawasan terhadap pekerja, menambah rambu K3 di area pabrik, menambah APD cadangan di area pabrik.
ANALISIS PENGUKURAN KINERJA DAN PERENCANAAN STRATEGI MENGGUNAKAN PENDEKATAN BALANCED SCORECARD DAN HOSHIN KANRI: STUDI KASUS DI PERUSAHAAN TEKSTIL
Authors: Sandrina Laura , Kosasih Wilson , Salomon Lithrone Laricha
Published: February 2024

Penelitian ini dilakukan di sebuah perusahaan manufaktur yang berfokus pada bidang tekstil khususnyabahan baku pembuat label tenun. Dalam perhitungan kinerja perusahaan saat ini, yang diperhatikan secara garis besar yaitu aspek finansial, sehingga aspek lainnya belum diperhatikan. Persaingan ketat pada pangsa pasar saat ini tentu akan membuat kondisi perusahaan mengalami penurunan. Maka dari itu diperlukan adanya pengukuran kinerja serta perencanaan strategi. Perhitungan kinerja ini menggunakan metode Balanced Scorecard yang kemudian didapatkan 12 Key Performance Indicator (KPI), yang kemudian dilakukan perhitungan bobot dengan Objective Matrix dan Traffic Light System. Didapatkan hasil pembobotan Balanced Scorecard berturut-turut yaitu: Perspektif Keuangan 0,428, Perspektif Pelanggan 0,332, Perspektif Proses Bisnis Internal 0,119, Perspektif Pembelajaran dan Pertumbuhan 0,121. Hasil Penilaian dengan Objective Matrix dan Traffic Light System diperoleh hasil 5 indikator sudah baik, 2 indikator kinerja belum maksimal, dan 5 indikator kinerja perlu untuk diperbaiki. Kemudian dilanjutkan untuk perencanaan strategi menggunakan metode Hoshin Kanri dengan X-Matrix.
PERANCANGAN DENGAN MENGGUNAKAN METODE REVERSE ENGINEERING DAN VDI 2221 PADA PRODUK MEJA BELAJAR MULTIFUNGSI
Authors: Hery  , Adianto  , Daywin Frans Jusuf
Published: February 2024

Indekos merupakan sebuah pilihan bagi pelajar ataupun mahasiswa/i yang berkuliah atau bersekolah di luar kota yang jauh dari orang tuanya. Para pemilik indekos yang disewakan, pasti akan menyediakan meja belajar pada setiap kamarnya untuk para penyewa untuk memenuhi kebutuhan mereka. Namun kebanyakan meja belajar yang disediakan kurang praktis dan kurang ergonomis, sehingga akan menyebabkan para penyewa tersebut kekurangan ruang untuk melakukan aktivitas – aktivitas lainnya. Oleh karena itu, pada penelitian ini dilakukan perancangan ulang terhadap produk meja belajar multifungsi yang tersedia di pasaran dengan menggunakan metode reverse engineering dan VDI 2221. Penelitian ini dilakukan untuk merancang sebuah meja belajar yang dapat menyelesaikan masalah di atas, yaitu sebuah meja belajar yang memiliki beberapa fitur tambahan pada produk tersebut seperti menambahkan fitur kasur multifungsi yang bisa menjadi sofa yang di mana akan menghemat ruang yang digunakan, menambahkan fitur tempat meletakkan printer di bagian bawah meja yang di mana akan membantu kepraktisan produk tersebut dalam melakukan kegiatan pencetakan, menambahkan fitur coolfan pada produk tersebut, menambahkan fitur meja ganda pada meja belajar tersebut yang di mana satu meja untuk meletakkan monitor dan di meja lainnya yang tersedia coolfan untuk meletakkan laptop dengan kasur sebagai tempat duduknya. Penelitian ini akan dilakukan dengan menggunakan kuisioner untuk mengetahui kebutuhan masyarakat dan benchmark terhadap meja belajar multifungsi yang telah beredar di pasaran saat ini untuk mengetahui ukuran dan fitur produk pesaing dan menyesuaikannya pada produk yang akan dirancang ulang.
The Positive Identification of Skeletal Remains from the Church of the Assumption of the Virgin Mary in Přeštice: a Case Study
Authors:   Department of the History of the Middle Ages, Museum of West Bohemia, Kopeckého sady 2, 301 00 Pilsen, Czech Republic, Sneberger Jiri ,   Department of Genetics and Microbiology, Faculty of Science, Charles University in Prague, Viničná 5, 128 43 Prague 2, Czech Republic,   Nuclear Physics Institute of the Czech Academy of Sciences, Na Truhlářce 39/64, 180 86 Prague, Czech Republic,   Institute of Archaeology of the Czech Academy of Sciences, Letenská 123/4, 118 00 Prague, Czech Republic, Tejček Michal ,   House of History in Přeštice, Třebízského 24, 334 01 Přeštice, Czech Republic, Lungová Veronika ,   Department of the History of the Middle Ages, Museum of West Bohemia, Kopeckého sady 2, 301 00 Pilsen, Czech Republic
Published: February 2024

The reconstruction and subsequent rescue archaeological excavation in the baroque chapel of St Barbara in the Church of the Assumption of the Virgin Mary in Přeštice has resulted in the discovery of one atypical burial in a small bricked vault. The vault contained skeletal remains in a very poor state of preservation. The discovery of the skeletal remains in the chapel was unexpected given the absence of any signs of a grave being present. In this article we describe the attempt to identify the person to whom the skeletal remains belong. Based on anthropological analysis, these remains were interpreted as probably female over 50 years of age. By combining archaeological context, anthropological analysis and historical sources, the skeleton was interpreted as the remains of Marie Anna Lindauer, a resident of Pilsen and the mother of Josef Ondřej Lindauer, the dean in Přeštice and the bishop in Budweis.
Current State of Archaeobotanical Research in Ghana: On Diet, Food Resources and Research Perspectives
Authors:   University of South Bohemia, Faculty of Science, Laboratory of Archaeobotany and Palaeoecology, Na Zlaté stoce 3, 370 05 České Budějovice, Czech Republic, Ayipey Patricia ,   University of South Bohemia, Institute of Archaeology, Faculty of Arts, Branišovská 31a, 370 05 České Budějovice, Czech Republic, Kuma Dela ,   University of Pittsburgh, Department of Anthropology, WWPH, 3302 S Bouquet St, Pittsburgh. PA 15260, USA, Beneš Jaromír ,   University of South Bohemia, Faculty of Science, Laboratory of Archaeobotany and Palaeoecology, Na Zlaté stoce 3, 370 05 České Budějovice, Czech Republic,   University of South Bohemia, Institute of Archaeology, Faculty of Arts, Branišovská 31a, 370 05 České Budějovice, Czech Republic
Published: February 2024

This review delves into the changes in food consumption patterns over time in West Africa, emphasising the significant role played by archaeobotanical studies. West African food consumption has been influenced by various factors such as economic, environmental, and external influences. Our initial studies focused on plant and animal domestication and the spread of grains. The arrival of Europeans in the 15th century brought changes in foodways, introducing new crops from the New and Old World. Some misconceptions about African food and agriculture have been challenged, accentuating the region’s diversity and resilience. The paper discusses the initial focus on economic factors and the domestication of plants, leading to a better understanding of the connection between food and society. Additionally, it dispels misapprehensions about West African cuisine and highlights the impact of the Atlantic trade on foodways. The study underscores the significance of interdisciplinary research in rectifying any biases surrounding Africa’s food history. Archaeobotanical research has shed light on the dynamic nature of African foodways, including the integration of American crops into local food traditions. However, knowledge of the extent of adoption and use of these crops during the precolonial era remains limited. More research is required to comprehend the adoption of American crops and the resilience of African food systems.
Importance and Determination of Body Electric Current Pre and Post Feeding in Turkish Karayaka Sheep
Authors: Bayram Rıdvan , Çelikyürek Hasan , Koyun Hasan
Published: February 2024

Many scientific studies are conducted directly or indirectly with humans, animals, and plants. We believe that body electricity, which is generated and constantly present in the bodies of living beings, should be considered in scientific studies as an effective factor for production activity. We believe that body electricity should be included in the environment to bring the rumen fluids of sheep used in Daisy II rumen simulators closer to reality. In this way, the most realistic environment is created by adding the influencing factors of body electricity and many factors that can affect the outcome. The study was conducted on a total of 16 Karayaka ewes, including 4 lambs, 4 one-year-old ewes, 4 pregnant ewes and 4 lactating ewes. The data obtained in the study were collected by measuring the body electricity of the animals before and after grazing in 3 different periods for each group. At the end of the study, it was found that the value of body electricity of sheep determined at 0.12±0.001 v (volt) before feeding was higher than the value determined at 0.09±0.002 v after feeding. The difference between the two values was found to be statistically significant (P<0.05). However, it was found that the fact that the live weights of the animals in the groups were different and they were in different physiological periods did not cause a significant (P>0.05) difference in the electrical body currents before and after feeding (except in lambs (P<0.05)). It can be said that the measurements made in other periods and groups can change the electrical body currents after feeding and that the electrical body currents differ according to the animals fed in the barn, especially during the grazing period, before going to pasture and when returning to pasture.
Effect of Initial pH on the Microbial Growth, Final pH Value, Crude Protein and Ash Level of Agaricus bisporus Cap and Stem in Submerged Fermentation
Authors: Güngör Bahar , Özlü Şevket , Güngör Emrah , Altop Aydın , Erener Güray
Published: February 2024

The aim of the study was to investigate the effect of submerged fermentation with Lactobacillus spp. on the nutritional composition of Agaricus bisporus cap and stem. Fresh A. bisporus was provided, and the cap and stem parts were separated and cut into small pieces. Afterward, distilled water (400 ml) and urea (8.4 g) were added to the mushroom parts (100 g) and placed in different fermentation flasks. The fermentation flasks containing mushroom caps or stems were divided into two groups, and the pH levels of the fermentation medium were adjusted to 6 and 7. Fermentation flasks were autoclaved at 121°C for 15 minutes and Lactobacillus spp. was inoculated to each flask at 1 ml (108 CFU/ml). A positive control group was formed by allocating one uninoculated flask for each replicate of each pH value. Fermentation flasks were incubated for 48 hours at 30°C. After fermentation, fermented and inoculated mushroom cap and stem were analyzed to determine the crude protein, ash content, Lactobacillus spp. count and pH value. Lactobacillus spp. count was higher (P=0.028) in the pH 6 group of mushroom cap and tended to be higher (P=0.078) in the pH 6 group of mushroom stems compared with the pH 7 group. Submerged fermentation decreased (P<0.001) the ash content of the mushroom cap and stem in both pH values except the cap with pH 7 compared with the uninoculated mushroom. Similarly, the fermented mushroom cap and stem had lower (P<0.01) final pH values in both initial pH values. Lactobacillus spp. increased (P<0.001) the crude protein content of the mushroom cap with pH 6 but did not alter the crude protein content with pH 7. Besides, submerged fermentation decreased (P<0.001) the crude protein content of mushroom stem with both pH values. The results indicate that submerged fermentation using Lactobacillus spp. can be used to improve the nutritional composition of mushroom caps with pH 6.
Causalidad y volatilidad en el índice Colcap de la Bolsa de valores de Colombia por contagios y muertes por Covid-19
Authors: Solano-Benavides Elcira , Alandete-Brochero Nelson
Published: February 2024

Este artículo analiza la causalidad y volatilidad del índice Colcap de la Bolsa de Valores de Colombia por contagios y muertes por Covid-19. La metodología es econométrica mediante la estimación de los tests de causalidad de Granger lineal y no lineal. Los resultados obtenidos con los tests muestran que hubo una sobrerreacción de los inversionistas de la Bolsa de valores a los contagios y muertes por COVID-19. Así mismo, el test de causalidad no lineal determinó que los inversionistas tuvieron en cuenta para la decisión de inversión, la evolución de los contagios de los últimos tres a 10 días y del número de muertes los últimos 15 días. En cambio, el test de Granger lineal indica que tuvieron en cuenta la evolución de los contagios y muertes en los últimos 11 días.
Tiempo de viudez. Experiencia vivida y agencia política en La casa viuda y muebles Sin título de Doris Salcedo
Authors: Pineda Repizo Adryan Fabrizio
Published: February 2024

Este texto propone que, a través de un análisis de las obras de Doris Salcedo, La casa viuda y muebles Sin título, es posible aproximarnos a la expresión de la experiencia vivida de las víctimas del conflicto armado, sus sensaciones y estados de fragilidad y vulnerabilidad. En particular, los muebles de estas dos series de Salcedo revelan, a través de su objetualidad, intertextualidad y situacionalidad, la agencia política de la obra de arte que tiene lugar a través de la manera en que hace confluir en el sentir la expresión del dolor y la sensación de impotencia que atraviesa la vida afectada por la violencia. Al poner en diálogo estas obras con conceptos críticos y algunas aproximaciones literarias a las víctimas de la violencia, emerge la posibilidad de interpretar la condición de viudez como un rasgo característico del sentir expresado por la obra que colapsa el tiempo y obliga al espectador a participar de la condición espectral del dolor que materializa la poética del objeto en la obra.
TINJAUAN PTSL KOTA BATAM MENURUT MENTERI AGRARIA DAN TATA RUANG NOMOR 6 TAHUN 2018
Authors: Novaldo Adam  , Endang Suparsetyani
Published: February 2024

Land registration is an important element to develop a land registration system within the scope of simultaneous registration for all villages and sub-districts. Main questions are whether the implementation of complete systematic land registration program in Batam has been carried out as stipulated in the Regulation of the Minister of Agrarian and Spatial Planning/Head of BPN No. 6 of 2018, how is the implementation of the complete systematic land registration regulation policy in Batam and how is Batam Government's effort to reduce the difficulty of realizing the complete systematic land registration program. Theseresearch wield normative juridical method with analytical descriptive type. The results of the research on the implementation of complete systematic land registration program in Batam are implemented through 13 stages, same as the program policy in the Regulation of the Minister of Agrarian Affairs and Spatial Planning/Head of the National Land Agency No. 6 of 2018. PTSL certificates are issued systematically, or by requiring the owner of the result user to pay both the annual mandatory fee and the Implementation Fee. Conclusion, the solutions are community counseling, collaboration with local government, getting rid of old villages, BPHTB payment rules, and cooperation with stakeholders including the Batam government.
PERBANDINGAN SISTEM PARLEMEN BIKAMERAL DI INDONESIA DAN FILIPINA
Authors: Ibnu Kuncoro  , Ninuk  Wijiningsih
Published: February 2024

Sistem parlemen bikameral merupakan sistem pembagian kamar dalam parlemen dalam hal ini kamar parlemen terbagi menjadi dua kamar yang teridiri dari majelis tinggi dan majelis rendah. Dalam parlemen Indonesia masih terdapat perbedaan pendapat antara para ahli mengenai penerapan sistem kamar manakah, sebagian ahli berpendapat bahwa Indonesia menerapkan soft bicameralism dan ada juga yang berpendapat bahwa Indonesia menerapkan tirkameral. Berdasarkan hal tersebut maka dilakukan perbandingan sistem bikameral di Indonesia dan Filipina, adapun permasalahan penelitian ini adalah apakah perbedaan dan persamaan sistem bikameral dalam lembaga legislatif di Indonesia dan Filipina?, apakah kelebihan dan kekurangan sistem bikameral yang diterapkan oleh Indonesia dan Filipina?. Penelitian ini bertipe yuridis normatif, yang bersifat deskriptif, dengan sumber utama data sekunder, yang dianalisis secara kualitatif dengan metode penarikan kesimpulan deduktif. Hasil dan kesimpulan dari penelitian adalah terdapat persamaan yang mendasar pada sistem parlemen bikameral di Indonesia dan Filipina yaitu semua lembaga legislatif dipilih melalui pemilihan umum, serta mendapatkan tugas umum lembaga legislatif, dan terdapat perbedaan dalam keseimbangan kewenangan antara kamarnya.
TINJAUAN YURIDIS PERUBAHAN PENGATURAN JAMINAN HARI TUA BERDASARKAN PERATURAN MENTERI KETENAGAKERJAAN REPUBLIK INDONESIA NOMOR 19 TAHUN 2015
Authors: Mohammad Farhan Fajari  , Andari Yurikosari
Published: February 2024

Penerbitan Peraturan Menteri Ketenagakerjaan Nomor 2 Tahun 2022 mendapat penolakan di masyarakat. Merespon hal tersebut pada tanggal 16 Maret 2022 Menteri Ketenagakerjaan, Ida Fauziyah menjelaskan bahwa aturan pencairan Jaminan Hari Tua (JHT) dalam proses revisi, sehingga pencairan JHT saat ini mengacu pada Peraturan Menteri Ketenagakerjaan Nomor 19 Tahun 2015 (Peraturan sebelumnya). Permenaker 19/2015 setelah Permenaker 2/2022 diundangkan adalah berstatus tidak berlaku dan telah dicabut dengan Peraturan yang baru (Permenaker 2/2022), lantas bagaimana status hukum Peraturan Menteri Ketenagakerjaan Nomor 19 Tahun 2015 jika di mengacu kepada landasan dan pedoma peraturan sesuai dengan Hierarki Peraturan Perundang-undangan, Apa telah sesuai dengan  Peraturan Pemerintah Republik Indonesia Nomor 12 Tahun 2011 tentang Pembentukan Peraturan Perundang-undangan.  Metode penelitian yang digunakan merupakan penelitian normatif yang bersifat dekriptif dengan bersumber pada data primer dan data sekunder, yang dianalisis secara kualitatif dengan penarikan kesimpulan secara deduktif.
Interstitial lung disease associated to systemic sclerosis – rescue treatment with tocilizumab
Authors: Nowakowska-Plaza Anna , Werońska-Tatara Joanna , Forys Agnieszka , Wisłowska Małgorzata
Published: February 2024

Choroba śródmiąższowa płuc jest jedną z głównych przyczyn śmiertelności w przebiegu twardziny układowej. Na wczesnym etapie pacjenci nie prezentują objawów klinicznych i mogą pozostać niezdiagnozowani. Wymagają szerokiej diagnostyki, w tym tomografii komputerowej i testów czynnościowych płuc. Klasyczne opcje terapeutyczne mają ograniczoną skuteczność, dlatego choroba śródmiąższowa płuc w przebiegu twardziny układowej pozostaje ciągle wyzwaniem terapeutycznym dla klinicystów. Praca prezentuje przypadek młodej pacjentki z ciężką twardziną układową powikłaną chorobą śródmiąższową płuc oporną na leczenie metotreksatem, cyklofosfamidem i mykofenolanem mofetilu. W leczeniu zastosowano tocilizumab jako nową opcję terapeutyczną z obiecującym wczesnym efektem. Wykrywalność choroby śródmiąższowej płuc w przebiegu twardziny układowej i zakres możliwości terapeutycznych poprawiły się w ostatnich latach. Powstały rekomendacje diagnostyczne i terapeutyczne. Jedną z obiecujących metod wydaje się być tocilizumab, przeciwciało monoklonalne skierowane przeciwko receptorowi IL-6, zaaprobowane przez FDA w 2021 roku w tym wskazaniu.
Congenital tumor of the oral cavity – epulis neonatorum. Case report
Authors: Raczkowska-Łabuda Karolina , Niemczyk-Cieślak Elżbieta , Zawadzka-Głos Lidia
Published: February 2024

A newborn baby with congenital epulis can be a startling sight for both parents and medics involved in the care of a neonate. These benign neonatal tumours can be exceptionally big, occupying a significant portion of the oral cavity and posing a risk of airway obstruction and significantly hindering feeding. Prenatal diagnosis remains difficult due to late tumour development and non-specific findings (ultrasound/MRI). The treatment of choice remains surgical excision of the tumour. In our report, we present a description of two cases of neonates operated at the Department of Pediatric Otorhinolaryngology of the Medical University of Warsaw, at the turn of 2020/2021. In both cases the diagnosis was made at birth and histopathological examination confirmed the diagnosis of congenital granular cell tumour (CGCT). The growths were excised under general anaesthesia with a good postoperative outcome, which allowed oral feeding on the second postoperative day.
Case study of a 7-years old patient with central auditory processing disorder on the autism spectrum disorder – Department of Pediatric Otolaryngology, Medical University of Warsaw
Authors: Dwornik Julia , Rigall Bartosz , Zawadzka-Głos Lidia
Published: February 2024

Central Auditory Processing Disorder (CAPD) is a condition in which sounds are not processed well by the auditory cortex. This disorder is often associated with others, such as dyslexia or autism spectrum disorder. Nowadays, there are many therapeutic methods for CAPD. One of them is active auditory training Neuroflow. Seven-years old boy on the autism spectrum disorder underwent the CAPD diagnostics using Neuroflow tests. He reported troubles with concentration, aural memory, understanding speech and hyperacusis. He also has significant problems in school due to that disturbances. After starting Neuroflow therapy, significant, but gradual progress was noticed in his both everyday and school life. Two more diagnostic sessions were performed and the results were getting better every time. Neuroflow is a tool used in various therapeutic disciplines. It is distinguished by its versatility, online conducting and parental participation. This type of therapy can be helpful in the treatment of not only CAPD, but also similar disorders, such as ASD.
Adjuvant therapy for recurrent respiratory papillomatosis
Authors: Raczkowska-Łabuda Karolina , Izdebska-Badełek Małgorzata , Zawadzka-Głos Lidia
Published: February 2024

Recurrent respiratory papillomatosis (RRP) is a relatively rare disease with potentially devastating consequences for the patient. Its course is unpredictable, ranging from mild disease and spontaneous remission to aggressive disease with pulmonary dissemination and the need for frequent surgery. It can also have a chronic clinical course and cause potentially life-threatening airway damage. A number of alternative medical therapies to standard surgical treatment have been investigated in recent decades, but the results of these studies remain moderate. Recent years have brought significant changes in the incidence of the disease due to breakthroughs in vaccination and prevention of human papillomavirus (HPV) or related pathology. In Poland and many other countries, RRP is not a notifiable disease, hence current data is very limited. It has been accepted to refer to RRP as Juvenile-onset papillomatosis (JoRRP) when the disease occurs in childhood, otherwise it is Adult-onset RRP (AoRRP). This review will present the most promising directions in the fight and prevention of this disease.
Wykorzystanie Panelu FilmArray® Meningitis/Encephalitis w diagnostyce zakażeń ośrodkowego układu nerwowego u dzieci
Authors: Wojtczuk Renata
Published: February 2024

Acute infection of the central nervous system (CNS) is a serious diagnostic and therapeutic problem. It is a potentially life-threatening condition, therefore any suspected central nervous system infection requires urgent diagnosis. The etiology of CNS infection is diverse and depends on many elements. Cerebrospinal fluid (CSF) examination confirms the infection of the CNS and identifies the causative agent. The available diagnostic methods have their limitations. Molecular tests, including the use of comprehensive molecular panels, such as Film Array Meningitis/Encephalitis, facilitate the precise diagnosis of the etiological factor, but they cannot and should not replace routine CSF tests, but should complement them.
Cities and destroying ‘the other’
Authors: Szpak Agnieszka
Published: February 2024

The aim of this article is to show that cities are very often attacked because of their characteristic of ‘otherness’. ‘The other’ may be understood as other religion, other ethnicity, other culture, other political views or other people which is closely related to the idea of diversity, heterogeneity, pluralism and density as essential features of contemporary cities. The author examines theories explaining motives for destroying cities like the latter being a part of genocide or a distinct theory of urbicide. Finally the author proposes looking at the destruction of cities through the lens of destroying ‘the other’ and the possibility of a community. The research methods used include desk research and formal-legal analysis. Formal-legal analysis focuses on the jurisprudence of the International Criminal Tribunal for the former Yugoslavia and the desk research on the relevant literature at the intersection of urban studies and international studies.
COVID-19 e aspectos psicossociais e econômicos na população brasileira
Authors: Montagnoli Débora Rosana Alves Braga Silva , Bezerra Carina Bandeira , Saintrain Maria Vieira de Lima , Brito Edla Helena Salles de
Published: February 2024

Objective: This study aimed to identify the psychosocial and economic characteristics of people affected by COVID-19 and their support network at the beginning of the pandemic. Methods: We conducted a cross-sectional study of 2,702 people aged 18 and over living in Brazil. Google® Forms were used to develop an online questionnaire containing open- and closed-ended questions about sociodemographic, economic and health characteristics. Results: People dissatisfied with their health and those who showed emotional changes were more likely to need support (PR=1.74; p<0.001 and PR=2.39; p<0.001). Support from family members stood out [536 (70.2%)]. Bivariate and multivariate analysis showed statistically significant associations of COVID-19 infection with sociodemographic and economic aspects, such as age (p<0.001); region of the country (p<0.001), marital status (p=0.003), number of people per household (p=0.003), employment status (p=0.012), holding a health insurance (p=0.014), needing some other type of support (p<0.001) and not being satisfied with current health status (p=0.043). Conclusion: The findings indicate that COVID-19 negatively affects satisfaction with health and influences the need to seek some type of social support.
Fatores que influenciam a falta de adesão ao tratamento da diabetes mellitus tipo 2
Authors: Barros Cecília Rafaela Hortegal Andrade , Sarmento Karolina Peres da Silva , Dias Filho Carlos Alberto Alves
Published: February 2024

Objetivo: Identificar os fatores que influenciam a falta de adesão ao tratamento de pacientes com Diabetes mellitus tipo 2. Métodos: Trata-se de uma revisão integrativa da literatura nas bases de dados Literatura Latino Americana e do Caribe (LILACS) e MEDLINE via PubMed, indexadas à Biblioteca Virtual em Saúde (BVS), realizada no período entre setembro e outubro de 2023. Foram utilizados os descritores “Type 2 Diabetes Mellitus” e “Treatment Adherence”. Resultados: A amostra final foi composta por 08 (oito) artigos, os quais apontaram que os principais fatores que influenciam na falta de adesão ao tratamento da DM2 estão relacionados ao nível socioeconômico, a idade e ao gênero. Outros fatores são a prevalência de condições emocionais, a ausência de uma abordagem integrada de equipe multiprofissional em saúde e a falta de estratégias na promoção do autocuidado, especialmente da saúde do homem. Considerações finais: A educação em saúde desempenha um papel importante na adesão ao tratamento do diabetes tipo 2, que considerem os aspectos psicológicos e sociais dos pacientes, e que promova, sobretudo, mudanças em seu hábito de vida.
Comparative efficacy and therapeutic positioning of biologics in hidradenitis suppurativa: A systematic review with network meta-analysis of randomised trials
Authors: Husein-ElAhmed Husein , Husein-ElAhmed Sara
Published: February 2024

Background

Hidradenitis suppurativa (HS) is a challenging inflammatory skin condition. Recently, many different biologics have been tested for HS, but the paucity of head-to-head comparative trials makes it difficult to determine the real value of each biological intervention. We aimed to determine the relative efficacy among biologics in treating moderate-to-severe HS throughout a network meta-analysis (NMA) and, to identify which pathogenetic pathways may be the most appropriate to target.

Methods

We comprehensively identified studies in 3 databases and clinicaltrials.gov. The eligibility criteria included randomised controlled trials (RCTs) reporting data on the efficacy of moderate-to-severe HS.

Results

The NMA comprised 13 studies comprising 14 interventions on 2,748 participants in the network. The NMA showed the odds of achieving the clinical response were significantly superior with adalimumab (RR: 0.37, 95% CI = 0.06–0.63), adalimumab QW (RR: 0.63, 95% CI = 0.43–0.87), MAB1p (RR: 1.33, 95% CI = 0.03–3.12), secukinumab (RR: 0.25, 95% CI = 0.11–0.47) and secukinumabQ2W (RR: 0.24, 95% CI = 0.1–0.46) compared to placebo.

Conclusion

Based on the NMA, inhibiting tumour necrosis factor (TNF)-a with adalimumab appears to be the best strategy, followed by the blockade of IL--17 with secukinumab. Data for bimekizumab and CJM112 are promising. Infliximab has inconsistent clinical response, and more data are necessary to confirm this molecule as a potential third-line therapy in HS. The blockade of IL-23 and CD5a pathways is not relevant, or at least the current evidence is insufficient to recommend further investigation of guselkumab, risankizumab, and vilobelimab in phase III trials.
Optimization and Characterization of Adsorbent from Palm Kernel Shell Waste Using H3PO4 Activator
Authors: Herlambang M. Julian , Ramandani Adityas Agung , Cendekia Devy , Alvita Livia Rhea , Wulandari Yeni Ria , Shintawati Shintawati , Purnani Mawar Siti , Efendi Dimas Amirul Mukminin Nur
Published: February 2024

Palm kernel shell is solid waste produced from the processing of crude palm oil (CPO). In this context, phosphoric acid (H3PO4) serves as an essential activator for producing an adsorbent with maximum micropore under operating conditions at a temperature of <450oC. Therefore, this study aimed to determine the optimal adsorbent condition of the palm kernel shell using H3PO4activator. The production process was optimized using Response Surface Methodology (RSM) and Central Composite Design (CCD) methods with activator concentration variations of 4%, 5%, and 6%, at activation times of 23 hours, 24 hours, and 25 hours, respectively. The quality of the adsorbent produced fulfilled SNI standard 06-3730-1995, characterized by water content of 1.001%, ash content of 5.767%, missing substance level of 18.932%, and fixed carbon content of 75.301%. Furthermore, this work effectively optimized the RSM and CCD adsorbent production process, achieving 4.785% variation in activator concentration and 24.679 hours activation time.
PENGARUH LITERASI KEUANGAN, UANG SAKU, DAN GAYA HIDUP TERHADAP MINAT MENABUNG MAHASISWA PENDIDIKAN EKONOMI FKIP UNTAN
Authors: Razi Safwan , Syahrudin Husni , Budiman Jumardi
Published: February 2024

This study aims to determine the effect of financial literacy, pocket money, and lifestyle on the interest in saving economic education students FKIP Tanjungpura University Pontianak. The sampel in this study amounted to 103 of the population of 157 students. This research method uses quantitative research with path analysis. The data collection technique used a questionnaire which was distributed to economic education students from class 2020 to 2022. The result of this study found that financial literacy has an effect on interest in saving whit a significant value of 0.628, pocket money does not have a significant effect on interest in saving whit a significant value of 0.336 and a path coefficient value of 0.115, and lifestyle does not have a significant effect on interest in saving economic education students FKIP Untan with a significant value of 0.387 and a path coefficient value of -0.098. Financial literacy through lifestyle affects the interest in saving of economic education students of FKIP Untan with a path coefficient value of 0.659. My money through lifestyl affects the interest in saving of economic education students of FKIP Untan with a path coefficient value of 0.160.
Posterior Reversible Encephalopathy Syndrome in an Elderly Patient with Acute Myeloid Leukemia
Authors:   West Virginia University Section of Hematology and Oncology, Department of Internal Medicine, USA, Lee Yu Stephen , Deepak Vishal ,   Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University Langone Health, New York, USA, Safi Salah Ud Din ,   West Virginia University Section of Hematology and Oncology, Department of Internal Medicine, USA, Sangani Rahul ,   West Virginia University, Section of Pulmonary Critical Care and Sleep Medicine, Department of Internal Medicine, USA, Hadique Sarah ,   West Virginia University, Section of Pulmonary Critical Care and Sleep Medicine, Department of Internal Medicine, USA
Published: February 2024

Posterior Reversible Encephalopathy Syndrome (PRES) is a neurological condition presenting with encephalopathy, seizures and headache with concurrent edema in the posterior cerebral circulation. While hypertension is the most common associated, PRES has been reported in patients receiving chemotherapy for various cancers such as AML. We report a 61-year-old female with history of hypertension who presented with sepsis and a new diagnosis of Acute Myeloid Leukemia (AML). She was started on broad spectrum antibiotics for her sepsis concurrently with Azacitidine and Venetoclax for treatment of sepsis and AML, respectively. Shortly after initiation of her AML treatment, patient became encephalopathic and experienced tonic clonic seizures. She had clinical and imaging features consistent with PRES. PRES has been reported as rare complication of chemotherapy of various cancer generally, and AML specifically. It is important to recognize it in a timely manner to prevent further damage. This case report highlights this important complication of the chemotherapy initiation in AML especially in elderly patient who presented with sepsis.
Augmentation of Structure Information to the Sequence-Based Machine Learning-Assisted Directed Protein Evolution
Authors: Yutzy Lane , Nguyen Kenny , Vallet Peter , Li Jianxiong , Yu Jielin , He Ronggui , Yan Le , Kim Joohyun , Jung Jangwook
Published: February 2024

Directed evolution (DE) mimics natural selection to improve the functions of a target protein. Machine learning (ML) has significantly streamlined DE by aiding in several steps, which includes identifying starting variants, generating diverse libraries and modeling sequence-fitness relationships. To date, the majority of ML-assisted DE (MLDE) approaches has relied predominantly on sequence information due to the challenges and cost of obtaining protein structure information. Here, we introduce a structure-augmented MLDE (saMLDE) approach for selecting high fitness variants from a library of Protein G B1 domain. We adopted and applied a zero-shot sequence-based prediction method (offering the potential to discover new insights without extensive training data) to select an initial training library of 96 variants for the saMLDE campaign. To leverage protein structure information, we used protein structure prediction with AlphaFold2 and molecular docking simulations performed with Rosetta FlexPepDock, resulting in structure-based features derived with an induced fit model. After three rounds of the saMLDE campaign, we demonstrated that saMLDE incorporating structural information gradually improves the average fitness scores and the precision of predicted binders. In addition, we found that the initial library selection with zero-shot subset selection methods significantly impacted the average fitness scores and precision, consequently influencing the overall directed evolutionary trajectories.
(Semi-) Automatic Review Process for Common Compound Characterization Data in Organic Synthesis
Authors: Huang Yu-Chieh , Tremouilhac Pierre , Kuhn Stefan , Huang Pei-Chi , Lin Chia-Lin , Schlörer Nils , Taubert Oskar , Götz Markus , Jung Nicole , Bräse Stefan
Published: February 2024

A method for data review in chemical sciences with a focus on data for the characterization of synthetic molecules is described. As current procedures for data curation in chemistry rely almost exclusively on manual checking or peer reviewing, a (semi-)automatic procedure for the evaluation of data assigned to molecular structures is proposed and demonstrated. The information usually required for the identification of isolated compounds is used to clarify whether the data is complete with respect to the available data types and metadata, if it is consistent with the proposed structure and if it is plausible in comparison to simulated data. Spectra prediction and automatic signal comparison are applied to NMR evaluation, mass spectrometry data are evaluated by signal extraction, and machine learning is used for IR analysis. The proposed protocol shows how an integration of different tools for data analysis can help to overcome the challenges of the currently purely manual reviewing and curation efforts for data in synthetic chemistry.
Controlling Rates and Reversibilities of Elimination Reactions of Hydroxybenzylammoniums by Tuning Dearomatization Energies
Authors: Fu Zihuan , Treacy Joseph , Hosier Brock , Houk Kendall , Maynard Heather
Published: February 2024

Hydroxybenzylammonium compounds can undergo a reversible 1,4- or 1,6-elimination to afford quinone methide intermediates after release of the amine. These molecules are useful for the reversible conjugation of payloads to amines in proteins and peptides. We hypothesized that aromaticity could be used to alter the rate of reversibility as a distinct driving force. We describe the use of density functional theory (DFT) calculations to determine the effect of aromaticity on the rate of release of the amine from hydroxybenzylammonium compounds. Namely, altering the aromatic scaffold to lower the energy of dearomatization reduces the kinetic barrier and prevents the reversibility of the amine elimination. We consequently synthesized a small library of polycyclic hydroxybenzylammoniums, which resulted in a range of release half-lives from 18 minutes to 350 hours. The novel mechanistic insight provided in this study significantly expands the range of release rates amenable to hydroxybenzylammonium-containing compounds. This work is useful for the field of traceless, self-immolative linkers as it provides another way to affect the rate of payload release.
Green synthesis of silver nanomaterials using Ganoderma Lucidum extract as reducing agent and stabilizer with ultrasonic assistance and application as an antibacterial agent
Authors: Nguyen Thu Huong , Nguyen Vinh Phu , Le Thi Hoa , Tran Thai Hoa
Published: February 2024

Synthesis of silver nanoparticles (AgNPs) using plant extracts extracted from Ganoderma lucidum in the buffer zone of Bach Ma National Park, Vietnam is a simple, convenient, economical, and environmentally friendly method. This study describes the biosynthesis of silver nanoparticles in both cases with and without ultrasonic assistance using Ganoderma lucidum extract as a reducing and protective agent. Transmission electron microscopy, scanning electron microscopy, X-ray diffraction, energy-dispersive X-ray spectroscopy, and Fourier transform infrared spectroscopy were used to characterize the as-synthesized AgNPs. Compared to the heating reflux method, the proposed ultrasonic wave assisted heating reflux method produced AgNPs had higher efficiency, smaller and more uniform particle size 6.08 ± 1.80 nm of nm in a short synthesis time period. The antibacterial and antifungal properties of ultrasonically synthesized silver nanomaterials (US-AgNPs) were also investigated. US-AgNPs are important nanomaterials that can find many good applications in practice.