bluuebunny/crossref_metadata_2025 huggingface dataset:
In vitro Antimicrobial and Antioxidant Activity of Meliaceae Plants Collection of Eka Karya Bali Botanic Garden
Authors: Li’aini Arrohmatus Syafaqoh , Wibawa I Putu Agus Hendra , Rahayu Ayyu
Published: December 2022

Meliaceae are popularly used to produce terpenoid and limonoid compounds. These compounds have the potential as antioxidants, antimicrobials, insecticides, antipyretics, and anthelmintics. This research aims to determine the antioxidant and antimicrobial activity of Meliaceae leaves extract of Eka Karya Bali Botanic Garden plants collection. The dried leaves of 15 species of Meliaceae were extracted by methanol. In vitro antimicrobial tests were carried out on agar media inoculated by selected microbe. On the other hand, the antioxidant activity was assayed by 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging. As a result, Aphanamixis polystachya against Aspergillus niger (35.21 mm) and Cladosporium sp. (46.21), Toona hexandra against Fusarium solani (37.31 mm), Dysoxylum cauliflorum against Candida albicans (38.19 mm), Chisocheton pentandrus against Salmonella typhimurium (39.53 mm), Sandoricum koetjape against Staphylococcus aureus (50.07 mm), and Toona hexandra against Streptococcus nutans (42.25 mm) exhibited the strongest inhibitory effect. Furthermore, the antioxidant screening showed that Cipadessa baccifera, C. pentandrus, and Sandoricum koetjape exhibited strong antioxidant activity, while T. ciliata showed a very strong antioxidant activity with IC50 33.64 μg/mL. This study reveals an initial screening of the potential of various types of Meliaceae as a source of antioxidants and antibacterials. Furthermore, this information can be used as a new alternative for pharmaceutical companies and the industrial sector in the development of new products.
Preparation of [Fe(paptH)2] (CF3SO3)2 and [Fe(paptH)2] [Fe(CN)5NO] (paptH = bis(2-(pyridin-2-ylamino)-4-(pyridin-2-yl)thiazole: Magnetic, Mössbauer, and Electronic Spectral Properties
Authors: Sugiyarto Kristian Handoyo , Goodwin Harold Andrew
Published: December 2022

Complexes of [Fe(paptH)2][X]2.nH2O, (paptH = 2-(pyridin-2-ylamino)-4-(pyridin-2-yl)- thiazole, X = CF3SO3 and n = 1.5, and X2 = [Fe(CN)5NO] and n = 3) have been characterized in magnetic, Mössbauer, and electronic spectral properties. The studies reveal that the two complexes are predominantly quintet state at room temperature, but singlet at low temperature (below 91K). The change is assigned as a thermally spin state transition, singlet 1A1g (LS, low-spin) ↔ quintet 5T2g (HS, high-spin), in iron(II), being gradual, continuous, and incomplete at the experimental temperature range, and without hysteresis in these instances. The two complexes were yellowish brown at room temperature (~ 298K) but darkening to reddish brown at the lower temperatures.
Study of The Spatial Footprint of Street Vendors During the Covid-19 Pandemic
Authors: Akbar Arfan Nur , Fuad Achmad Hery
Published: December 2022

This article examines the use of urban space by street vendors during the Covid-19 pandemic. To suppress the spread of Covid-19, adjustments are made to activities in urban spaces, especially in the economic and social sectors. The purpose of this study is to explore the existence of street vendors in the city's green lane in terms of their benefits, problems, and strategies in dealing with the Covid-19 pandemic. This study uses a qualitative method by looking at the research deductively as well as the application of the theory of the production of space by Lefebvre as well as daily studies to reveal the actual situation. Researchers conducted spatial mapping to describe the pattern of street vendors' activities through four typological aspects such as commodities and facilities, temporal, space, and movement. This article shows that spatial mapping also shows the movement and activity of users in space. Spatial practice between street vendors and the community in public spaces can form a strong social space and there is a need for space management during pandemic. Keywords: Covid-19 Pandemic; Social Interaction; Street Vendors; Urban Space
Analysis of Embodied Energy in the Construction of The Prototype of Rammed Earth Wall
Authors: Suprahman Faiz Hamdi , Nurafifah Nisrina
Published: December 2022

The construction sector has become the main target for reducing carbon emissions and world energy consumption in this decade. Reducing the energy consumption of buildings is an effective strategy for reducing carbon emissions. To achieve this kind of condition, the selection of building materials is an important factor, so the attempt to examine alternative building materials needs to be made. One of the attempts is by maximizing the potential of soil as a raw material. The technology of rammed earth wall has existed for centuries and now it is considered a sustainable material, but it has not yet become a popular discourse of alternative building material in Indonesia. This research aims to analyze embodied energy in rammed earth applications. This preliminary research was conducted using the LCA inventory data method that was achieved by making a partial prototype of the rammed earth wall. This research resulted in several recommendations for rammed earth wall applications to reduce carbon emissions during the construction process. Keywords: Alternative Material; Energy Analysis; Rammed Earth Wall; Sustainable Material
Preservation of Cultural Heritage Buildings with the Adaptive Re-Use Method: A Content Analysis of Past Research
Authors: Ningsih Tri Astuti Ratna , Agustiananda Putu Ayu P , Sholihah Arif Budi
Published: December 2022

Buildings that make adaptive reuse, in general, are buildings that were previously buildings that emphasized their historical values, then changed and disadvantaged changes. In this study, the adaptive reuse building used is a change of function into a building that has value. The purpose of this study is to provide insight and dissect research that discusses adaptive reuse buildings on several continents in the world. Evaluation techniques are carried out by analyzing using tables and grouping each case study from previous research. The methods used in the study are comparative qualitative methods and data analysis using literature studies related to adaptive reuse theory relating to tourism and economic theory. The results of the study, it is expected to provide input and suggestions, which can later be used and used as proof that buildings that have experienced adaptive reuse also have valuable benefits for the building itself and the surrounding environment. Keywords: adaptive re-use; case study; environment; historical value; the continent in the world
TINJAUAN SYARIAH TERHADAP TUJUAN INVENSI CRYPTOCURRENCY SEBAGAI INSTRUMEN TRANSAKSI FUTURISTIK
Authors: Uun Zahrotunnisa  , Iin Fadila Ramadhani  , Fuat Hasanudin
Published: December 2022

Perkembangan dunia digital kini menuntut manusia melakukan aktivitas secara cepat, begitupun hal nya peranti yang digunakan harus dapat digunakan dimana dan kapan saja. Digitalisasi tidak hanya terjadi pada teknologi komunikasi melainkan juga berkembang pada kegiatan perekonomian, contohnya uang. Perkembangan teknologiyang masif menyebabkan uang sebagai alat tukar di modifikasi menjadi virtual. Sebagai produk industri 4.0 crypto mencuri perhatian para investor berkat eksistensinya dalam menawarkan keunggulannya dan berusaha menyaingi keberadaan uang fiat. Aset kripto yang memiliki jumlah user tertinggi saat ini adalah Bitcoin. Apabila ditilik lebih lanjut sistem yang dijalankan oleh cryptocurrency ditemukan unsur spekulasi dan ketidakjelasan dimana sewaktu-waktu dapat terjadi fluktuasi tinggi dan menyebabkan anjloknya nilai kripto sehingga berpotensi menimbulkan kerugian besar bagi user. Unsur merugikan ini tidak dibenarkan dalam hukum Syar’i. Penelitian ini menggunakan metode library research melalui pendekatan normatif syariah yang bersifat deskriptif analisis. Kemudian, dalam proses identifikasi dalam literature review ditemukan pokok permasalahan. Sumber data primer yang digunakan adalah Fatwa MUI, Peraturan Menteri Perdagangan, Peraturan Bank Indonesia, data sekunder diperoleh melaluipengkajian Kitab Fiqh, Karya Ilmiah, artikel, dan berita. Middle theory dan applied theory dinilai tepat untuk merumuskan hasil penelitian hukum normatif syariah dengan mengaplikasikan analisis SWOT. Tujuan dan urgensi penelitian dipaparkan mengenai hukum syar’i dari unsur-unsur sistem kripto untuk jangka panjang. Uang kripto tidak dapat dijadikan alat tukar maupun investasi jangka panjang, karena tidak ada kebijakan yang menjamin perlindungan kerugian konsumen jika terjadi fluktuasi, dalam kaidah ushul fiqh disebutkan Dar'ul-mafasid muqaddamun ‘ala jalbil-mashalih.
Front Matter
Authors: Zen Bita Parga
Published: December 2022

Front Matter November 2022
Implementasi Metode Waterfall Pada Perancangan Aplikasi Rekam Medis Berbasis Website dan Whatshap Gateway
Authors: Yunita Ika Romadoni , Pramono Agus , Waluyo Retno , . Suliswaningsih
Published: December 2022

Rekam medis menjadi sebuah dokumen wajib harus dimiliki oleh tempat pelayanan kesehatan. Dengan adanya rekam medis menjadi pertimbangan seorang doketer untuk melakukan tindakan medis kepada pasien. Dokter XYZ membuka praktek di Patikraja, Banyumas. Rekam medis yang ada selama ini masih menggunakan kertas sehingga terdapat beberapa permasalahan yang dialami, diantaranya data rekam medis hilang serta rusak, data rekam medis lebih dari satu dan pasien tidak datang saat jadwal chek up. Untuk itu diperlukan pemanfaat teknologi untuk mengatasi permasalahan tersebut. Oleh karena itu tujuan peneltian ini akan membuat aplikasi rekam medis berbasis website dan whatshap gateway. Sedangkan metode yang digunakan untuk pengembangan sistem yaitu metode waterfall. Penelitian ini menyimpulkan metode waterfall dapat digunakan untuk membuat aplikasi rekam medis berbasis website dan whatshap gateway, setelah dilakukan pengujian black box secara kesuluruan kebutuhan fungsional perangkat lunak sudah berfungsi sesuai keinginan pengguna. Dengan adanya aplikasi ini mempermudah proses administrasi dan pengarsipan rekam medis secara digital.
FABRY DISEASE: Switch from Enzyme Replacement Therapy to Oral Chaperone Migalastat. What Do We Know Today?
Authors: Perretta Fernando , Jaurretche Sebastián
Published: December 2022

Fabry disease is a lysosomal storage disorder caused by the deficiency of the α-galactosidase-A enzyme. Cardiac, renal, and neurological involvement significantly reduces life expectancy. Until a few years ago, treatment options for Fabry disease were limited to enzyme replacement therapy with agalsidase alfa or beta administered by intravenous infusion every 2 weeks. Migalastat (Galafold®) is an oral pharmacological chaperone that increases enzyme activity of “amenable” mutations. The safety and efficacy of migalastat were supported in the phase III FACETS and ATTRACT studies, compared to available enzyme replacement therapies; showing a reduction in left ventricular mass, and stabilization of kidney function and plasma Lyso-Gb3. Similar results were confirmed in subsequent extension publications, both in patients who started migalastat as their first treatment and in patients who were previously on enzyme replacement therapy and switched to migalastat. In this review we describe the safety and efficacy of switching from enzyme replacement therapy to migalastat in patients with Fabry disease and “amenable” mutations, referring to publications available to date.
Improving Vegetation Spatial Distribution Mapping in Arid and on Coastal Dune Systems Using GPR
Authors: Gomez Christopher , Jiaqi Liu , Jing Wu , Persendt Frans , Bradak Balazs , Yousefi Saleh , Sri Hadmoko Danang
Published: December 2022

Desertification and dune progression over vegetation is quantified using remote sensing data, but vegetation, eventually temporarily, buried under sand blowout may escape such assessment, and to estimate the extent of buried vegetation, a GPR campaign was conducted over the coastal sand-dune of Tottori Prefecture (Japan) in combination with a high-resolution topographic UAV-based survey of the topography. The result shows that buried vegetation exists underneath sand-blowout, especially near the dune ridges, and that this vegetation can extend 20 – 30 m further than the estimation made from airborne remote sensing. Furthermore, the presence of palaeo-vegetation in palaeodune layers also provide information on the long-term evolution of sand dunes (with periods of stability vs rapid change), which can be used to reconstruct Quaternary coastal environments.
Is it all about Surface Topography? An Intraindividual Clinical Outcome Analysis of Two Different Implant Surfaces in Breast Reconstruction
Authors: Schoberleitner Ines , Augustin Angela , Egle Daniel , Brunner Christine , Amort Birgit , Zelger Bettina , Brunner Andrea , Wolfram Dolores
Published: December 2022

The most common long-term complication of silicone breast implants (SMI) remains capsular fibrosis. The etiology of this exaggerated implant encapsulation is multifactorial but primarily induced by the host response towards the foreign material silicone. Identified risk factors included specific implant topographies. Of note, breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), has only been observed in response to textured surface implants. We hypothesize that reduction of SMI surface roughness causes less host response hence better cosmetic outcome with fewer complications for the patient. A total of 7 patients received the routinely used CPX®4 breast expander (~60 µM Ra) and the novel SmoothSilk® (~ 4 µM Ra), fixed prepectoral with a titanised mesh pocket and randomized to the left or right breast after bilateral prophylactic NSME (nipple-sparing mastectomy). We aimed to compare the postoperative outcome regarding capsule thickness, seroma formation, rippling, implant dislocation as well as comfortability and practicability. Our analysis shows that surface roughness is an influential parameter in controlling fibrotic implant encapsulation. First time intra-individually compared in patients, our data confirm an improved biocompatibility with minor capsule formation around SmoothSilk® implants with an average shell roughness of 4 µM and in addition an amplification of host response by titanised implant pockets.
Chihuahua Hoy: 20 años generando conocimiento
Authors: Sena Herrera Erika
Published: December 2022

Este año celebramos la publicación del volumen 20 de Chihuahua Hoy. Desde sus inicios, se ha trabajado arduamente para que este proyecto se consolide como una empresa intelectual y generadora de conocimiento, tanto para el estado de Chihuahua como para el resto del país. En sus vol.menes publicados podrán consultar trabajos de la más alta calidad académica acerca de las distintas realidades de nuestra región
El nuevo proletariado del norte en Ciudad Juárez
Authors: Acosta Pérez Nolberto Tlacaelel
Published: December 2022

El surgimiento de la ahora renombrada Industria Manufacturera, Maquiladora y de Servicios de Exportación trajo consigo la formación de un nuevo sujeto obrero en la región: el nuevo proletariado del norte. La propuesta del presente artículo consiste en identificar y describir los rasgos específicos de esta subfracción de clase proletaria a partir de una reevaluación de su significado, los indicadores socioeconómicos más relevantes que sirven para entenderla, los episodios de organización política que ha emprendido en los últimos años y sus atributos culturales más característicos.
Causas de muerte de la población infantil en Ciudad Juárez, 1953-1954
Authors: Santiago Quijada Guadalupe
Published: December 2022

En este artículo se presenta un estudio acerca de las causas de muerte de la población infantil en Ciudad Juárez, al inicio de la segunda mitad del siglo XX. El propósito es indagar en la respuesta gubernamental y en las actividades que realizaron las instituciones de salud locales para hacer frente a las enfermedades y evitar que aumentara el número de fallecimientos. De manera particular, se describen las acciones de la sociedad para abatir los padecimientos y proteger a la niñez. Con respecto a las fuentes de información para conocer las causas de muerte, se revisaron y cuantificaron los datos inscritos en los libros de defunciones de 1953 y 1954 que se localizan en el Registro Civil de Ciudad Juárez. Además, se examinó el periódico El Fronterizo y bibliografía diversa para establecer el contexto histórico y urbano en que sucedió esta tragedia.
Violencia estructural contra niñas, niños y adolescentes en Chihuahua
Authors: Castro Loera Héctor Edgardo , Orozco Lopez Gabriela
Published: December 2022

En el marco de la filosofía y su función social se estudia la violencia estructural contra niñas, niños y adolescentes en Chihuahua; para aproximarse al fenómeno y plantear alternativas se relacionarán tres teorías, i) los estudios feministas respecto a la violencia, se emplearán conceptos como la interseccionalidad, pedagogías de la crueldad y violencia estructural; ii) la filosofía de los derechos del niño, se apreciará el juego como una necesidad y posición jurídica de libertad; y iii) el evento del Aufklärung, es decir, la asimilación del presente de la humanidad o la Iluminación en el pensamiento de Foucault.
Interests of Muzaki to Pay Zakat: The Role of Accountability, Transparency, Service Quality, and Financial Technology
Authors: Bahri Efri Syamsul , Putri Riesya Aulia , Romansyah Dadang
Published: December 2022

The obligation to pay zakat is regulated in the Qur'an and is a pillar of Islam. Management of zakat is regulated in Law No. 23 of 2011. This study examines the factors that influence the interest of muzaki to pay zakat. This research is a survey of 35 respondents, muzaki in the National Amil Zakat Agency (Baznas). This study uses quantitative methods with purposive sampling. The data were analyzed using partial least square-structural equation modeling (PLS-SEM), which was then processed using the SmartPLS application. Accountability has a positive and significant effect on the interest of muzaki in paying zakat. Transparency, service quality, and fintech have a positive but not significant effect on interest in paying zakat. This study included very little data. Therefore, further research can investigate these factors with an increasing number of samples. Practical implications by considering the antecedents of muzakki's interest in paying zakat, zakat management bodies can improve accountability, transparency, service quality, and fintech in zakat management
Subjective Meaning of Strategic Pricing Decision Making based on Islamic Values in the Muslim Business community
Authors: Junaedi Wahyu , Prihanisetyo Adi
Published: December 2022

Fierce competition in business often encourages businesses to act unreasonably in their pricing strategies. Orientation to maximum profit often trumps the ethical values derived from religious teachings. This study aims to find the meaning of strategic pricing decision-making of Muslim businessmen based on their awareness of Islamic values. Islamic values arise from the perception of business people as a reflection of knowledge about Islamic ethics that they understand. The research method used is transcendental phenomenology. The sampling was conducted on five businesspeople members of the Indonesian Islamic Business Forum (IIBF).  This study found that Muslim businessmen Interpret strategic pricing decision-making according to their awareness of Islamic values as a form of justice, namely fairness in pricing based on market segments and based on product value-added. This research will provide knowledge to business people to consider ethics in the strategic policy of price management conducted.
In situ and time
Authors: Bauer Andrew
Published: December 2022

Large-scale HPC simulations with their inherent I/O bottleneck have made in situ visualization an essential approach for data analysis, although the idea of in situ visualization dates back to the era of coprocessing in the 1990s. In situ coupling of analysis and visualization to a live simulation circumvents writing raw data to disk for post-mortem analysis -- an approach that is already inefficient for today's very large simulation codes. Instead, with in situ visualization, data abstracts are generated that provide a much higher level of expressiveness per byte. Therefore, more details can be computed and stored for later analysis, providing more insight than traditional methods. This workshop encouraged talks on methods and workflows that have been used for large-scale parallel visualization, with a particular focus on the in situ case.
Combining Variable Neighbourhood with Gradient Ascent for Learning to Rank Problem
Authors: Ibrahim Osman Ali Sadek , Younis Eman M. G.
Published: December 2022

Variable Neighbourhood Search (VNS) is used to optimize the solutions for heuristic problems. Solutions are based on neighboring solution systematic changes. The changes are made during the ascending phase to get local optimum and the perturbation phase to gain the global optimum solutions. Exploration and Exploitation procedures are made through various mutation step-size. The objective function to choose the best offspring to be move to the next evolving generation. Thus, this paper uses a variation of VNS based on four random probability distributions with Gradient Ascent for adapting the mutation of Neighborhood solution in the next iteration. It has the ability moderate the next proposed neighbourhood based of the Parent and Offspring fitness values. We called this novel approach in Learning to Rank (LTR) as Gradient Variable Neighbourhood (GVN). This variant generates each Offspring ranking model solution from one probability distribution in the whole mutation procedure (all mutation step-sizes made by only one probability distribution for each Neighbourhood candidate). From the obtained results, we can conclude that the GVN method outperformed the recent research of Evolutionary and Machine Learning methods. In the experiments, we used Yahoo, Microsoft Bing Search (MSLR-WEB10K) and LETOR 4 (MQ2008, MQ2007) datasets.
Study on Knowledge of Cardiac Arrest and Its Management Among Health Care Professional Students in Chennai and Kanchipuram
Authors: E Nirman Kanna D. , J Nanthini , R Tamilvanan , Arumugam Sasikumar
Published: December 2022

Background: Cardiac arrest is the most common cause of death worldwide, and early intervention with high quality BLS improves a victim’s chances of survival. A patient in cardiac arrest is treated by early CPR and early defibrillation and administration of Emergency Drugs. Therefore, Every Health Care Professional student should be Knowledgeable about cardiac arrest and its management to save the precious life of patient.
Objective: To assess the Knowledge of Cardiac Arrest and its management among Health Care Professional Students and to educate and create awareness and Knowledge about Cardiac arrest and its management among Heath Care Professional Students
Methodology: A cross sectional study conducted in Chennai and Kanchipuram, from July 9th 2022 to September 9th 2022. Permission was obtained from IEC; a well-organized questionnaire was executed with 23 items using the Google Forms. Pre- structured questions were pre-validated by Experts. Google form contains the details such as socio-demographic, knowledge and its management-based questions. The Completed data was collected, entered in excel sheet and the results was analyzed with the proper statistical method.
Results: According to the statistical analysis of data received, it results, only 4% (21 participants) of health care professional students have good knowledge about cardiac arrest and its management, only 36% (188 participants) of health care professional students have adequate knowledge about cardiac arrest and its management and 60% (316 participants) of health care professional students have inadequate knowledge about cardiac arrest and its management.
Conclusion: This study highly suggests that training programs, simulation-based trainings, seminars and Lecture, etc.… need to be organized to the health care professional students to make them gain knowledge about cardiac arrest and its management to save the precious lives.
A novel risk prediction nomogram to predict 30-day mortality in older patients with sepsis
Authors: Li Fang , Zhou Wei-Feng , Pan Min , Wang Shu
Published: December 2022

Background: Sepsis is a common clinical disease with a high mortality rate, and the prognosis of older patients with sepsis varies. The purpose of this study was to determine the prognostic factors in older patients with sepsis and to establish a prognostic model for predicting short-term mortality in older adults with sepsis, as early intervention is recommended to reduce case fatality rate.
Methods: We reviewed 426 older patients with sepsis and collected their demographic details, clinical information, and data on biological markers for the first time within 24 hours of hospital admission. At the same time, we calculated a Nutrition Risk Screening (NRS-2002) score. In a 7:3 ratio, these patients were randomly divided into a training group (n = 298) and validation group (n = 128). The lasso regression model was used to reduce data dimensions and select features. To construct a prognostic signature, Cox regression analysis was used, based on which a nomogram was developed, and its predictive accuracy was evaluated. The discrimination, calibration, and clinical usefulness of the nomogram were assessed using calibration curves and decision curve analysis (DCA).
Results: Albumin (ALB) level, blood urea nitrogen (BUN) level, lactic acid level, and NRS-2002 score were independent risk factors that affected the 30-day prognosis of older patients with sepsis (P＜0.05). The area under the receiver operating characteristic (ROC) curve (AUC) values of the nomogram of the training and validation groups were 0.772 (95% CI, 0.734-0.812) and 0.730 (95% CI, 0.695–0.766), respectively. The calibration curves fit well in the two groups.
Conclusions: We developed and validated a prognostic nomogram model based on ALB, BUN, and lactic acid levels and NRS-2002 score for older patients with sepsis. This model can help clinicians timely assess the early risk of death in older patients with sepsis and accordingly take proactive measures.
DMA2022 Microscopic mechanism of cyclic hardening/softening of a TRIP-aided duplex stainless steel
Authors: Zou Zongyuan , Song Bibo , Wang Hongzhong , Chen Lei , Jin Miao
Published: December 2022

To further promote high performance transformation-induced plasticity (TRIP) duplex stainless steel’s industrial application in lightweight design of automotive structural parts, the cyclic softening/hardening properties and its microscopic mechanism of a TRIP duplex stainless steel Fe-19.33Cr-1.92Ni-2.7Mn-1.8Si is studied. Symmetrical cyclic loading tests with different strain amplitudes under strain control were conducted. The variation curves of the hysteresis loop and stress amplitude with cycles are obtained, and its cyclic hardening/softening characteristics is analyzed. An experimental study on the microstructure observation of a typical strain amplitude of 1.1% under quasi-in-situ cyclic loading was carried out by Electron Backscattered Diffraction (EBSD) and Transmission Electron Microscope (TEM). The combination of macroscopic mechanical properties and microstructure observation found that the entanglement of dislocations, dislocation interaction and grain boundaries' hindrance to dislocations are the main reasons for the initial cyclic hardening of the test steel. The formation of dislocation walls and dislocation cells leads to subsequent cyclic softening. At the secondary hardening stage, stable low-energy dislocation cells have little effect on the test steel's cyclic hardening/softening properties. The secondary cyclic hardening is mainly dominated by strain-induced ε martensite and α' martensite.
All-inside Arthroscopic Release for Iliotibial Band Syndrome. Description of Surgical Technique and Short-term Results
Authors: Arnal-Burró Juan , Vidal-Fernández Carlos , Igualada-Blázquez Cristina , Cuervas-Mons Manuel , Martínez-Ayora Álvaro , Santos-Vaquinhas Alex Dos
Published: December 2022

Introduction:
Description of an arthroscopic procedure (all-inside arthroscopic release, AIAR) that combines all the possible interventions on the iliotibial band (ITB), and evaluates its outcomes in a group of distance runners diagnosed with ITBS.
Methods
A prospective observational study was made of distance runners diagnosed with ITBS and operated upon using the AIAR technique between 1 January 2018 and 31 June 2020. The surgical technique is described in detail, and the demographic data and functional outcomes measured by the ARS and IKDC sports performance scales are presented.
Results
A total of 14 patients were included, with a mean follow-up of 16 months (range 12–42 months). In all cases, statistically significant improvement was evidenced by the ARS and IKDC scales following AIAR (p = 0.00048), with excellent outcomes in 71% of the cases according to the ARS scale and in 86% according to the IKDC scale (mean difference of 11.9/16 and 33.8/100 points, respectively). No complications were recorded.
Conclusion
The AIAT technique is effective in allowing a return to previous sports performance levels in a short period of time among patients with ITBS refractory to conservative management, with a high satisfaction rate and the absence of complications.
The Effects of Enhanced Formaldehyde Clearance by Applying the NIOSH Hierarchy of Controls in a Gross Anatomy Laboratory
Authors: Durongphan Anuch , Rungruang Jarun , Nitimanee Eakkapong , Pamornpol Benjaporn
Published: December 2022

To date, no learning method substitutes cadaver dissection, but formaldehyde exposure is a significant health concern in the gross anatomy laboratory. Our 2018 study found that most formaldehyde levels in the breathing zone (S-level) and environment (R-level) during laboratory sessions at the Faculty of Medicine of Siriraj Hospital exceed ceiling standards. In this study, we enhanced engineering control of the NIOSH hierarchy of controls by removing the intervening factors of formaldehyde clearance by increasing the area per table and opening the covers of the dissection table, then measuring the ceiling levels by formaldehyde detector tube with a gas-piston hand pump. The analyses excluded the 2018 perineum region data because of the laboratory closure from the COVID-19 outbreak in 2019. There were statistically significant differences between the 2018 and 2019 S-levels (p< 0.001) and R-levels (p<0.001). The mean S-level decreased by 64.18% from 1.34 ± 0.71 ppm to 0.48 ± 0.26 ppm, and the mean R-level decreased by 70.18% from (0.57 ± 0.27 ppm) to (0.17± 0.09 ppm). The trend of the 2019 level is similar to our 2018 study, unlike other published studies showing high formaldehyde levels in the body cavity. The highest formaldehyde level in 2019 was the S-level in the body wall region (1.04 ± 0.3 ppm), followed by the S-level in the abdominal region (0.56 ± 0.08 ppm), and the spinal cord removal region (0.51 ± 0.29 ppm). All 2019 formaldehyde levels passed the OSHA 15 min STEL standard (2 ppm). The R-level in the special sense region (0.06 ± 0.02 ppm) passed the NIOSH 15-min ceiling limit (0.1 ppm). Three 2019 levels were very close: the R-level in the head-neck region (0.11 ± 0.08 ppm), the abdominal region (0.11 ± 0.08), the body wall region (0.14 ± 0.12 ppm), and the S-level in the special sense region (0.12 ± 0.04 ppm). The lower formaldehyde level in 2019 reflects that extensive analysis of individual laboratory formaldehyde clearance defects and correcting them by applying the NIOSH hierarchy of controls is an effective measure.
Deep Evolutionary Forecasting identifies highly-mutated SARS-CoV-2 variants via functional sequence-landscape enumeration
Authors: Colom Mireia Solà , Vucinic Jelena , Adolf-Bryfogle Jared , Bowman James W. , Verel Sébastien , Moczygemba Isabelle , Schiex Thomas , Simoncini David , Bahl Christopher D.
Published: December 2022

Host-pathogen interactions drive an evolutionary game of cat-and-mouse between a pathogen’s protein virulence factors, the host’s adaptive immune system, and therapeutics targeting the pathogen. There is an urgent need for treatments and prophylactics that remain effective as a pathogen evolves, and the ability to predict pathogen evolution is a longstanding challenge. Therefore, a common strategy has been to target conserved epitopes, but strong selective pressures can drive pathogens to evolve resistance nonetheless. Here, we report a novel, generally-applicable approach called Deep Evolutionary Forecasting that predicts protein evolution using artificial intelligence and molecular modeling. The first step is to perform a complete enumeration of the functional sequence landscape in silico for a target protein. Then, we construct a graph where the edges between sequence variants are weighted by evolutionary probability. Protein evolution is forecasted by traversing this graph. We chose the SARS-CoV-2 receptor binding domain (RBD) as a model system because highly-mutated viral variants have continued to emerge that escape available therapeutics and vaccines. The RBD variants that we forecasted carry up to 11 concurrent amino acid substitutions at the host receptor binding site. Pseudoviruses harboring forecasted RBDs are active and escape binding and neutralization by FDA-approved monoclonal antibody therapeutics. We identified bottlenecks in the evolutionary landscape of SARS-CoV-2 that are promising targets for therapeutics that preempt evolution.
Effect of anterior vaginal wall prolapse repair by modified transvaginal mesh surgery: a retrospective cohort study
Authors: HU Pan , LEI Li , WANG Ying , TANG Jing , Liu Lubin
Published: December 2022

Objective To explore clinical outcomes and complications of modified Transvaginal mesh (M-TVM) for advanced anterior vaginal wall prolapse in 1 year follow up.
Methods 574 patients underwent TVM surgeries from 2019 to 2020 were collected and divided into traditional TVM group and M-TVM group according to different surgeries, all preoperative and postoperative data was obtained and compared between the two groups.
Results 285 women were involved eventually, including 181 for TVM group and 104 for M-TVM group. No significant differences of general conditions were found between these two groups. During long-term follow up period, patients in TVM group were more likely to suffer pelvic pain than M-TVM group after surgery (P=0.046). Meshes placed with M-TVM protocol (4.5±0.69 cm) seemed much wider than meshes placed with TVM (3.0±0.91cm). Surgeries can significantly change a prolapse to point Aa and Ba on POP-Q compared to preoperative data. M-TVM procedures may significant change point C and D after surgery compared to TVM surgery(P＜0.001).
Conclusion M-TVM is a commendable procedure that can significant correct anterior prolapse with mesh extended wider, and also supply stable apical support at the same time.
Medieval migrations and the birth of modern British peoples: A craniometric approach
Authors: Valoriani Satu , Irish Joel D. , Megan King , Matteo Borrini
Published: December 2022

Craniometric characteristics can be used to reconstruct among-group variation, potential migration routes and ancestral origins. This study presents the results of the comparison of 946 individuals from 16 British medieval sites using craniometric analyses. The purpose is to determine if: 1) observable craniometric variation among British medieval groups exists, 2) it can be detected from neurocranial or facial measurements, and 3) the potential causes of these differences. Craniometric data were analyzed with multivariate statistical analyses. A selection of 18 variables recorded on each crania was used for comparison among pooled males and females. Principal component analysis was carried out on the mean measurements for each pooled group to detect differences among the samples. The results support previous work by other authors indicating a difference in craniometric measurements among British samples. Male and female samples follow the same discrimination pattern, indicating the validity of the statistical analysis. Both neurocranial and facial measurements contribute to the variability of the groups analyzed. The differences in craniometric measurements are likely determined by the migration of people from other European areas. The samples from the British cities where migration occurred more frequently during and before the Middle Ages (i.e. Hythe, London and Scarborough) confirm this difference. These towns were major ports in medieval times, and the movement of people was frequent, with different nationalities in each area (e.g. Scandinavian, Icelandic, Flemish, French). The hypothesis is further supported by correspondence of the results with historical and archaeological records.
Ground-glass opacity caused by the administration of amikacin liposome inhalation suspension: A case report
Authors: Hashimoto Kazuki , Nii Takuro , Sumitani Hitoshi , Yokoyama Masashi , Hashimoto Naoko , Matsuki Takanori , Tsujino Kazuyuki , Miki Keisuke , Kida Hiroshi
Published: December 2022

Background: Amikacin liposome inhalation suspension (ALIS) is a key drug for the treatment of refractory Mycobacterium avium complex pulmonary disease (MAC-PD), but causes hypersensitivity pneumonitis in rare cases.
Case presentation: A 72-year-old woman was treated with ALIS for refractory MAC-PD. Three weeks later, she was hospitalized for pneumonia. The nose swab PCR test for coronavirus disease 2019, and serum (1,3)-beta-D-glucan test, were negative. Because the opacities worsened after empiric antibiotic therapy, we started corticosteroids, suspecting drug-induced interstitial lung disease (DIILD) caused by ALIS; 3 days later, we found signs of improvement and quickly tapered the corticosteroids. After obtaining informed consent, we performed a drug provocation test of ALIS. Seven days later, she had a re-exacerbation of MAC-ID, leading to a diagnosis of DIILD caused by ALIS.
Conclusions: DIILD caused by ALIS is rare, but should be carefully diagnosed because various opacities appear on chest radiograph during the chronic course of the disease.
GPe Astrocytes and Prototypic Neurons Selectively Represent Routine Formation
Authors: Yang Minsu Abel , Hong Sa-Ik , Kang Shinwoo , Lee Jeyeon , Song Minryung , Lee Sang Wan , Choi Doo-Sup
Published: December 2022

The external globus pallidus (GPe) guides action selection. However, it remains elusive how diverse GPe cells engage in routine formation while learning action sequences in repetitive reward-seeking conditioning. Here, we investigated the Ca2+ signals of GPe cells during routine formation. We found that the dynamics of astrocytes and prototypic neurons’ activities are associated with the refinement of the action sequence, which enables cost-effective reward-seeking.
Adaptive Asymptotic stabilization of Uncertain Nonstrict Feedback Nonlinear HOFA Systems with Time Delays
Authors: Zhao Yuzhuo , Ma Dan , Zhang Yingwei
Published: December 2022

We consider the adaptive control for the nonstrict-feedback uncertain nonlinear high-order fully actuated (HOFA) systems with either uncertain constant delay or time-varying delay. Different from the previous works, the most difficult point is that the uncertain nonlinear function in the HOFA systems contains nonstrict feedback form and time delay in system states. In order to overcome this difficulty, the arbitrary approximation property of the radial basis function neural network (RBF NN) is used to estimate the unknown nonlinear functions. What’s more, the nonstrict-feedback form is transformed into strict-feedback strcture by using the property of Gaussian function. In addition, the appropriate Lyapunov-Krasovskii functions and separation techniques are used to compensate the effect of the unknown constant time delay or time-varying delay. Based on the HOFA system approaches, two adaptive NN controllers are proposed to ensure the system with constant time-delay and time-varying delay to be stabilized asymptotically, respectively. Finally, the proposed control strategies are applied to the thermoacoustic instability systems to demonstrate the feasibility and effectiveness of the obtained results.
New Distributed-TOPSIS Approach for Multi-Criteria Decision-Making Problems in a Big Data Context
Authors: LAMRINI Loubna , ABOUNAIMA Mohammed Chaouki , ALAOUI Mohammed TALIBI
Published: December 2022

Nowadays, the online environment is extra information-rich and allows companies to offer and receive more and more options and opportunities in multiple areas. Thus, decision-makers have abundantly available alternatives to choose from the best one or rank from the most to the least preferred. However, in the multicriteria decision-making field, most tools support a limited number of alternatives with as narrow criteria as possible. Decision-makers are forced to apply a screening or filtering method to reduce the size of the problem, which will slow down the process and eliminate some potential alternatives from the rest of the decision-making process. Implementing MCDM methods in high-performance parallel and distributed computing environments becomes crucial to ensure the scalability of multicriteria decision-making solutions in Big Data contexts, where one can consider a vast number of alternatives, each being described on the basis of a number of criteria.
In this context, we consider TOPSIS one of the most widely used MCDM methods. We present a parallel implementation of TOPSIS based on the MapReduce paradigm. This solution will reduce the response time of the decision-making process and facilitate the analysis of the robustness and sensitivity of the method in a high-dimension problem at a reasonable response time.
Three multicriteria analysis problems were evaluated to show the proposed approach's computational efficiency and performance. All experiments are carried out within GCP's Dataproc, a service allowing the execution of Apache Hadoop and Spark tasks in Google Cloud. The results of the tests obtained are very significant and promising.
Application of Attenuation Coefficient in the Assessment of Hepatic Involvment in Children and Adolescents with Wilson’s disease
Authors: Wang Jiajia , Wang Jinping , Wang Han , Li Boqi , Wang Yixing , Sun Lanting , Wu Xiaoqian
Published: December 2022

Background: To investigate whether the attenuation coefficient (ATT) can be used as a noninvasive index to assess liver involvement in children and adolescents with Wilson’s disease (WD).
Methods: Children and adolescents diagnosed with WD were retrospectively collected from the First Affiliated Hospital of the Anhui University of Traditional Chinese Medicine between May 2022 and August 2022. The findings on ATT, Shear Wave Measurement (SWM), AST to platelet ratio index (APRI), and fibrosis 4 (FIB-4) score were obtained. The liver involvement of WD was classified into 3 groups based on serum levels of collagen type IV (CIV), hyaluronic acid (HA), laminin (LN) and precollagen type III N-terminal peptide (PIIINP): (1) Group1 ( n=25), no abnormalities in CIV, HA, LN and PIIINP; (2) Group2 (n=19), elevation of 1 or 2 indexes in CIV, HA, LN, and PIIINP; Group3 (n=18), elevation of 3 or 4 indicators in CIV, HA, LN, and PIIINP. The levels of ATT, SWM, APRI and FIB-4 were compared between the 3 groups; and correlation of ATT with SWM and triglyceride (TG) was performed using Spearman's correlation analysis. The Receiver operating characteristic (ROC) curve was used to analyze the diagnostic efficacy of ATT alone and its combination with SWM, APRI, and FIB-4 in children and adolescents with WD.
Results: A total of 62 children and adolescents with WD were retrospectively retrieved. ATT levels were significantly different in intergroup comparisons (P <0.001). The ROC curve showed that the area under the curve (AUC) for the diagnosis of hepatic steatosis using ATT was 0.714, 0.712, and 0.867 in Group 1 vs. Group 2, Group 2 vs. Group 3, and Group 1 vs. Group 3, respectively; the sensitivity for the diagnosis of hepatic steatosis in Group 1 vs. Group 2 was 89.47% with the cutoff value of ATT of 0.73 dB/cm/MHz. No significant correlation found between ATT and TG (ρ = 0.154，P = 0.231). Compared to ATT alone, the combination of ATT with APRI and FIB-4 or the combination of ATT with SWM, APRI, and FIB-4 showed a better diagnostic efficacy in Group 1 vs. Group 2 (both P=0.038).
Conclusion: ATT could be used as a non-invasive index for the evaluation of liver steatosis in children and adolescents with WD, with a good clinical applicative value. Furthermore, ATT in combination with APRI, FIB-4, and SWM might have better diagnostic efficacy than ATT alone.
Invitro regeneration and standardization of Agrobacterium mediated transformation of immature embryo callus from Sweet sorghum
Authors: Yadala Ramakrishna , Bandi Jyotsna , Palle Surender Reddy , Syed Asha , Naravula Jalaja
Published: December 2022

Sweet sorghum is the present target and cheap source for biofuel production. Tissue culture recalcitrance and low levels of transformation reproducibility of protocols are main constrains for transgenic sweet sorghum development. Production of a transient transgenic sweet sorghum for the development of disease resistant transgenics was the aim of our studies. In this study we have developed an efficient regeneration and transformation system for in vitro culture of sweet sorghum from the immature embryo callus. Histological studies of sweet sorghum embryogenic calli revealed that the development of embryogenic shoots. Murashige and Skoog nutrient agar medium with different concentrations of 2mg/l 2,4-D and combination of 0.2 mg/l NAA and 2 mg/l Kinetin gave higher frequency of callus induction and shoot regeneration. Embryogenic callus was competent to accept the DNA with GV2600 strain. These tissues are susceptible to Agrobacterium mediated transformation carrying pCAMBIA1301 with gus gene construct as well as for shoot multiplication. For effective transformation, GV2600 strain carrying pCAMBIA1301 at 0.6 O.D. was found to be compatible in giving sweet sorghum transgenics. Molecular confirmation was done by Polymerase Chain Reaction and Southern blotting for the putative plants. The regenerated plantlets survived during acclimatization were growing similar to the normal plants. All the major parameters that affecting transformation frequency were optimized for the development of perfect sweet sorghum transgenics.
State Revenue Dependency on Resource: New Panel Evidence for Government Role in Resource – Inequality Nexus
Authors: Nguyen Khanh Hoang Dien
Published: December 2022

Despite the intensive amount of research on the resource-inequality nexus and the role of governance quality in modulating this linkage, their findings have been mixed at best. To further investigate the institution’s influence in this resource-inequality connection, this paper uses panel evidence from data on 77 countries over the period of 1996–2020, with novel dependent and independent variables which are directly tied to the government: resource revenue as a share in government income instead of in GDP as the independent variable, and absolute and relative redistribution as dependent variables in addition to the conventional GINI coefficients. Results from fixed-effects models on the panel dataset, both without and with lags, indicate a negative linear relationship between resource revenue and income inequality, but also suggest a threshold at which bad governance would overturn this beneficial effect. Analysis of potential mechanisms and policy recommendations are also discussed.